CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_AP021867	Stenotrophomonas maltophilia strain KMM 349	16 crisprs	WYL,DEDDh,csa3,cas3,DinG,PD-DExK	1	4	0	0

Cas Category Instructions

Results visualization

1. NZ_AP021867

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CRISPR-Cas detection and classification

Crispr_ID: NZ_AP021867_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP021867_1

760740-760820

Orphan

Consensus_repeat	Method
CTTGTAGAGTCGAGCCATGCTCGACT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP021867_1

>merge|NZ_AP021867|1|760740-760820|CRISPRCasFinder
CTTGTAGAGTCGAGCCATGCTCGACTATCGCGCGCAGCGCAGAATGTGTGGTCCCCTTGTAGAGTCGAGCCATGCTCGACT

>NZ_AP021867|1|1|760740-760820|CRISPRCasFinder
CTTGTAGAGTCGAGCCATGCTCGACT	ATCGCGCGCAGCGCAGAATGTGTGGTCCC
CTTGTAGAGTCGAGCCATGCTCGACT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP021867.1\|WP_065722790.1\|755319_756516_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237463
NZ_AP021867.1\|WP_012510072.1\|759932_760733_+\|UDP-2,3-diacylglucosamine-diphosphatase	unknown	unknown	gnl\|CDD\|277343
NZ_AP021867.1\|WP_153675008.1\|768845_770033_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
NZ_AP021867.1\|WP_012510075.1\|763069_764962_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|287142
NZ_AP021867.1\|WP_049399791.1\|754752_755259_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|224523
NZ_AP021867.1\|WP_153675002.1\|746211_747393_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376154
NZ_AP021867.1\|WP_004144283.1\|766165_767161_-\|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl\|CDD\|129820
NZ_AP021867.1\|WP_004144021.1\|745661_746135_-\|Cys-tRNA(Pro)-deacylase	unknown	unknown	gnl\|CDD\|237976
NZ_AP021867.1\|WP_153675005.1\|751924_754636_+\|phosphoenolpyruvate-carboxylase	unknown	unknown	gnl\|CDD\|234570
NZ_AP021867.1\|WP_004144334.1\|771077_772376_-\|nucleoside-transporter-NupC	unknown	unknown	gnl\|CDD\|224883
NZ_AP021867.1\|WP_153675003.1\|747549_748995_-\|adenosylhomocysteinase	unknown	unknown	gnl\|CDD\|377487
NZ_AP021867.1\|WP_012510077.1\|767319_767751_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_012510070.1\|756675_757887_-\|methionine-adenosyltransferase	unknown	unknown	gnl\|CDD\|235374
NZ_AP021867.1\|WP_012510078.1\|767832_768750_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176164
NZ_AP021867.1\|WP_153675006.1\|758220_759936_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|153248
NZ_AP021867.1\|WP_012510080.1\|770086_771052_-\|ribokinase	unknown	unknown	gnl\|CDD\|238579
NZ_AP021867.1\|WP_100467817.1\|760948_762004_+\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|377294
NZ_AP021867.1\|WP_004144220.1\|762062_763061_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133022
NZ_AP021867.1\|WP_153675004.1\|749235_751752_+\|prolyl-oligopeptidase-family-serine-peptidase	unknown	unknown	gnl\|CDD\|224423
NZ_AP021867.1\|WP_153675007.1\|765223_766051_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|181382

Protein	Function_ID	Function_description	E-value
NZ_AP021867.1\|WP_065722790.1\|755319_756516_-\|hypothetical-protein	gnl\|CDD\|237463	PRK13668, PRK13668, hypothetical protein; Provisional.	2.84886e-05
NZ_AP021867.1\|WP_012510072.1\|759932_760733_+\|UDP-2,3-diacylglucosamine-diphosphatase	gnl\|CDD\|277343	cd07398, MPP_YbbF-LpxH, Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain. YbbF/LpxH is an Escherichia coli UDP-2,3-diacylglucosamine hydrolase thought to catalyze the fourth step of lipid A biosynthesis, in which a precursor UDP-2,3-diacylglucosamine is hydrolyzed to yield 2,3-diacylglucosamine 1-phosphate and UMP. YbbF belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.43245e-69
NZ_AP021867.1\|WP_153675008.1\|768845_770033_+\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	8.64272e-71
NZ_AP021867.1\|WP_012510075.1\|763069_764962_-\|hypothetical-protein	gnl\|CDD\|287142	pfam10131, PTPS_related, 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein. This domain is found in various bacterial hypothetical membrane proteins, as well as in tetratricopeptide TPR_2 repeat protein. The exact function of the domain has not, as yet, been established.	0.00515049
NZ_AP021867.1\|WP_049399791.1\|754752_755259_-\|acyl-CoA-thioesterase	gnl\|CDD\|224523	COG1607, COG1607, Acyl-CoA hydrolase [Lipid metabolism].	6.3526e-64
NZ_AP021867.1\|WP_153675002.1\|746211_747393_-\|hypothetical-protein	gnl\|CDD\|376154	pfam18731, HEPN_Swt1, Swt1-like HEPN. Swt1-like HEPN. This HEPN domain might have a role in binding and sensing unspliced pre-mRNAs that are specifically targeted by the Swt1 nuclease at the nuclear envelope.	0.00684094
NZ_AP021867.1\|WP_004144283.1\|766165_767161_-\|tRNA-dihydrouridine-synthase-DusB	gnl\|CDD\|129820	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family. This model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). This branch includes NifR3 itself, from Rhodobacter capsulatus. It excludes a broadly distributed but more sparsely populated subfamily that contains sll0926 from Synechocystis PCC6803, HI0634 from Haemophilus influenzae, and BB0225 from Borrelia burgdorferi. It also excludes a shorter and more distant archaeal subfamily.The function of nifR3, a member of this family, is unknown, but it is found in an operon with nitrogen-sensing two component regulators in Rhodobacter capsulatus.Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase. [Unknown function, General].	5.11867e-148
NZ_AP021867.1\|WP_004144021.1\|745661_746135_-\|Cys-tRNA(Pro)-deacylase	gnl\|CDD\|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	1.52287e-75
NZ_AP021867.1\|WP_153675005.1\|751924_754636_+\|phosphoenolpyruvate-carboxylase	gnl\|CDD\|234570	PRK00009, PRK00009, phosphoenolpyruvate carboxylase; Reviewed.	0
NZ_AP021867.1\|WP_004144334.1\|771077_772376_-\|nucleoside-transporter-NupC	gnl\|CDD\|224883	COG1972, NupC, Nucleoside permease [Nucleotide transport and metabolism].	2.63974e-142
NZ_AP021867.1\|WP_153675003.1\|747549_748995_-\|adenosylhomocysteinase	gnl\|CDD\|377487	pfam05221, AdoHcyase, S-adenosyl-L-homocysteine hydrolase.	0
NZ_AP021867.1\|WP_012510070.1\|756675_757887_-\|methionine-adenosyltransferase	gnl\|CDD\|235374	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated.	0
NZ_AP021867.1\|WP_012510078.1\|767832_768750_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176164	cd08475, PBP2_CrgA_like_6, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 6. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.06125e-83
NZ_AP021867.1\|WP_153675006.1\|758220_759936_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|153248	cd07986, LPLAT_ACT14924-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.	3.48257e-57
NZ_AP021867.1\|WP_012510080.1\|770086_771052_-\|ribokinase	gnl\|CDD\|238579	cd01174, ribokinase, Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides and histidine, and for entry into the pentose phosphate pathway. Ribokinase is dimeric in solution.	7.69446e-100
NZ_AP021867.1\|WP_100467817.1\|760948_762004_+\|metal-dependent-hydrolase	gnl\|CDD\|377294	pfam04307, YdjM, LexA-binding, inner membrane-associated putative hydrolase. YdjM is a family of putative LexA-binding proteins. Members are predicted to be membrane-bound metal-dependent hydrolases that may be acting as phospholipases. It is a member of the SOS network, that rescues cells from UV and other DNA-damage. Expression of YdjM is regulated by LexA.	1.28107e-24
NZ_AP021867.1\|WP_004144220.1\|762062_763061_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|133022	cd04179, DPM_DPG-synthase_like, DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.	1.29033e-43
NZ_AP021867.1\|WP_153675004.1\|749235_751752_+\|prolyl-oligopeptidase-family-serine-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	5.36622e-56
NZ_AP021867.1\|WP_153675007.1\|765223_766051_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|181382	PRK08317, PRK08317, hypothetical protein; Provisional.	5.07027e-26

>NZ_AP021867.1|WP_012510072.1|759932_760733_+|UDP-2,3-diacylglucosamine-diphosphatase
MSALANLSPHRRAVFVSDVHLGSRHCHATELARFLSQLRCERLYLVGDIIDLWWMAHRRANWRQSHSEVIQALHALRRAGTEIIYIPGNHDASLRHVCGLMLPAMQVRRRAIHVTADGRRLLVAHGDDYDGVTHFGGLQEKFGDWLYYRILTGNQALNAVRRRLGMRYWSLSEFLKKRSGAAERYIERFVQAGLDDVRRRGLDGIVCGHIHRAALIERDGLVYANDGDWVESLTALAEDHDGALRLLDHNGQTLVELPGARIKQAA
>NZ_AP021867.1|WP_153675006.1|758220_759936_+|GNAT-family-N-acetyltransferase
MQELEQRLQQRFPDWFHGRRGQLARPLLRSVGRWSRLDQIEAFLQRSAGLRGFGFVAAGLEFIDGQYQVDPAALAKIPATGRLLIVANHPSGALDALALLDAVGRIRRDVRIVANDLLGAIAPLQDLLLPVRILGGKAQRGSLHAVEEALAAEQCVIVFPAGEVSRLSLRGIRDGRWQRGFVRFARAAGAPVLPVRVEARNSALFYGASTLFKPAGTALLAREMFTRRGRPLRLCIGEPMQLGKGGDPGAQLLAVRRALYALGRNGTTADAAAHGGPEPLAAPVPPSQVAAGIAAATQLGQTADGKQILLATCTADSPLLLELGRLRELTFRQVGEGTGRSRDLDAFDPQYEHIVIWDAAAQRIAGAYRIMRGAHALARHGLSGLYSASLFRYSDDAITHIAEGLELGRSFVVPDYWGSRSLDYLWQGIGAYLQCRPGIRYLFGAVSISAALPRDAREQLVAYYQRYYSGTAGLAESNRPFQYFAAPPSFGELDAGAAFDVLKANLAALGTGVPTLYRQYTDLCEPGGARFLAFGVDPDFSDSIDGLIEVDLCAIRPNKRKRYLRDAGTPA
>NZ_AP021867.1|WP_012510070.1|756675_757887_-|methionine-adenosyltransferase
MSSYLFTSESVSEGHPDKVADQISDAVLDAILTQDQRARVACETMVKTGVAIVAGEITTSAWIDLEALTRKVIVDIGYDSSDVGFDGATCGVLNLIGKQSPHIAQGVDRKKPEEMGAGDQGLMFGYATNETDSYMPAAIHLSHRLVEQQAKIRKKKNSPLSWLRPDAKSQVTLRYENGVVSAIDAVVLSTQHAPGIKQKDLIEAVREEIIKPVLPAKWLHKGTKFHINPTGKFEIGGPVGDCGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAARYVAKNVVAAGLADRCEVQVSYAIGVAEPTSISVTTFGTGKISDDKIEKLIRKHFDLRPYGIIKMLDLVHPMYQQTAAYGHFGRKPKEFSYLNGEGETVNATAFSWEKTDRAAALRADAKLK
>NZ_AP021867.1|WP_065722790.1|755319_756516_-|hypothetical-protein
MISRLLDRWFKDKPTPDAFAAKVIQTARRLGIDKPLEYQSDQFRIAYDGGSFFNLHNAYSAYLDVEHGRQRDVLERFTRILGLANEEPLPFAEIRDRLRPVIRNRNLLDQIILQEMEDNGLDARVSLQYRPLTGECVELLAVDYDEHTATQTRDLPEEWGITLEQALAIARDNLRALDDAPFIEIAPGLFRSAWGDAYDSSRVLMPELLHRLPLAGPPVFMLPTRDVLLVAGERDEQAQQAMIAQASEAMDDGRVISGDMHHYVEGHMQAFTPASETLQRAQRALRLQLHAGLYATQKEQLDKVHELHEHDVFVANFIVDGSNHISIGCWSEGVETSLPQTDFIALVVEERDTQMVEWDVAMREFGHLLEADTRHIHPPRYLTRGFPDTELRARVQPG
>NZ_AP021867.1|WP_049399791.1|754752_755259_-|acyl-CoA-thioesterase
MSTELKTHQLSMTVLMSPEMANFSGKVHGGAILRLLDQVAYACASRYAGSYVVTLSVDQVMFRQPIAVGELVTFLASVNYTGTSSMEIGIKVVAEDILKRSVRHANSCFFTMVAVDEEGRPTPVPSLQPVTSDEKRRQAAALIRRQLRQEMEQRHLELLASNPPSPEE
>NZ_AP021867.1|WP_153675005.1|751924_754636_+|phosphoenolpyruvate-carboxylase
MNEYRSSIEFASPDLPLRDDVRRLGALVGDLLVEQVSAAFLDDVEDVRTRAIARRENQAPLSELADGLAGRTPQQAETMVRAFSTYFQVVNIAERVHRIRRRRDYQRAGTAGAQPDGLQDALQHLKAQGVGLDELAQWLPRIDIEPVFTAHPTEAVRRALLEKEQLMVASLVDNLDGQRTPGEAAADAARFRMALTASWQTTDSSPVRPTVDDEREHVGFYLVQVLYRVIPVLYESLQQALRDTYGEELPLPRLLRFGTWVGGDMDGNPNVDATTIRNTLDAQRQAVLARYQKELLQLASLLSQSTERVGVSDALQARVAHYQQLLPQVQSRPRHADMPYRLLNDRMRARLQATLDDGVGAYAGPDELIEDLQLILDSLRANRGEHAGGFAVQRLLWRVKTFGFHLARLDVRQESSVHARALATVLGGDAAWDSLDAVGRARLLAPHASGDAPLPKGDDEGNQRLDAVFAALADARARHGGDALGSYIISMAHDRSDVLAVLALARRGGLVEEGGSVPLDIAPLFETVDDLKRGTATLRDLLADPVYRAHLHARDDVQMVMLGYSDSSKDGGIAASRWGLQRAQVELLEVAAEAGIRLTFFHGRGGSISRGGGKTTHAVDASPRGSIDGRLRVTEQGEVIHRKYGIRALALRSLEQATGAVLRASLRPRAAEPREDEWRPVMDVVAGSSSEVYRAFVGQSGFMDYFRTATPIDVIERMTLGSRPSRRLGQDAALGNLRAIPWVFAWSQARAVIPGWYGVGSGLQAAVDAGHEQTLREMARDWPFFRTFLDDIAMVLSKGDITIAEQFSKLSGDLHGRFFPQVEKELELTRHWLLALMGQQTLLDHDARLSLSIRLRNPYVDPISVLQVDLLQRWRESGREDEDLLRALVACVNGVSQGVQNTG
>NZ_AP021867.1|WP_153675004.1|749235_751752_+|prolyl-oligopeptidase-family-serine-peptidase
MSMHARRTRRWTGLVLSMGLLAVAPLAWAASPQPAQVQAQGVNGYELPSAALQAVVDAPRAPSLYLSPRRDVAAMMQMPSLPSIQVVAQPELKLAGLRINPRTFSDSRFSFGEKLWLMNVADGKERQISGLPAKLSIASVMWSPDQKWLAFNQVDAASGANELWLVDVAGGSARRLVAGLNTVIGSGYQWLPDSRGLVVFTRPANLGAAPAADGIPTGPAVQQTSQGGGVVSIRTYQDLLKNEADARQFDYYATTQPMEVSLDGNTRAIGAAGIFMGFAVSPDGRFVLRQPVQRPYSYVVPVSSFPRRIEVIDRASGKLVHTVAVRPLVEGLPTGNDAEVTGVRDISWRGDADATLVWAEAQDGGDPNREAKVRDAVLMQAAPFDKPPVTLAQLGSRLVGINWGRGDLALLTESWWKTRKTRTWLIAPDNAGAEPRLLWDRDGQDRYSDPGRPLLSSDDRGRSLLQTSADGSSLYLAGAGASPEGDRPFVDRFDVATGKATRLFHSQAPSYALPVALLDNQASSLLLSRESPDEPANFYVQSLADAGAAPRALTRFAHPLPQLKGVQKEQIRYKRKDGVDLTATLLLPPGYDPKRDGPRPLLMWAYPGEFKSAAAASQVTDSPYRFNAVSYWGPQAFLAKGYVVLASPSMPIIGEGDKEPNDTYIEQLVANAQAAVDEVVRRGVTDRDHIAIGGHSYGAFMTANLLAHTRLFKAGIARSGAYNRTLTPFGFQAEERNYWQAQDVYQKMAPFNYADKIKDPILFIHGVDDNNSGTFPMQSERMFAAVKGLGGTARLVMLPNESHAYRARESIMTMLAESERWLEQTIGPADQGKAKKKR
>NZ_AP021867.1|WP_153675003.1|747549_748995_-|adenosylhomocysteinase
MNAVAKTFSTEGDYKIRDITLADWGRKELDIAEHEMPGLMSIRRKYQAELPLKGVRVTGSLHMTIQTAVLIETLKDIGADVRWASCNIFSTQDHAAAAIAATGTPVFAWKGESLEEYWDCTLDALTFTLADGTLTGPELVVDDGGDVTLLIHKGYELENGSTWVNEPAASHEEQVIKNLLKRVATERPGYWGRVVKDWKGVSEETTTGVHRLYQLAQAGTLLIPAINVNDSVTKSKFDNLYGCRESLADGLKRAMDVMLAGKVAVVCGYGDVGKGCAASLRAYGARVIVTEIDPICALQAAMEGYEVNTIESTLGRADLYVTTTGNKDIIRIEHLSAMKDQAIVCNIGHFDNEIQVDALVGFKGVQHVNIKPQVDKYIFPNGNAIFLLAEGRLVNLGCATGHPSFVMSNSFANQTLAQIDLWANKDSYENKVYLLPKKLDEEVARLHLEKIGVKLTTLSQEQADYIGVPVEGPFKPDHYRY
>NZ_AP021867.1|WP_153675002.1|746211_747393_-|hypothetical-protein
MQWREATEIEGNSIRVPPTWLDLYYYEALNILFRFENSLRIFAYIILKKELGEKWDNAAISGNSTIRSETKKRLAQAREHGYLGYEVSSPMLYLNSGELTTIITSEAYWKHFAPYFKATKQIILNKLNEIGTVRNSLAHFRPLKKDDLDLIKQNTKHVLLEIETCIDRINSISSATPTNSDSEWYKKLSSIKNEVVEISLFQSQDQQWVRTEIGFKTPLLEKNQFGTHYFYYQLGKFRTEEMLKRYDSIRNACICVSEMPAFGNISNNHDVVFDQKISVIFHQKNLSDGIELIFNDFTEIAEKVEREVALLHEDRLTLGDLVKSESANASFVTNVESPFWSLNISSLNTPLESVDSIEFWGHRYHFSSNFVTDTNHYPWMPTAVSKPAWSGIQ
>NZ_AP021867.1|WP_004144021.1|745661_746135_-|Cys-tRNA(Pro)-deacylase
MTPAINLLKREKIAHTVRSYVHDAHAESYGGEAVEKLGLDPAQVFKTLLASTETHELLVAIVPVAGQLDLKALAEAAGCKKCEMAAADAAQRATGYLVGGISPLGQKKRLRTFLDASAQVLPSLHVSAGRRGLEVELAPADLLRLTAGHFAAIGKAR
>NZ_AP021867.1|WP_100467817.1|760948_762004_+|metal-dependent-hydrolase
MDSLTQIVLGGAVAAVIAPPGHRRAALLAGAALGTLPDLDALWLGFTAADPVANMIEHRSFSHSLLVLPWVAALIWWLFKRFGNGRVAQSPVRWFWAIQLALVTHPMLDAFTVYGTQLWWPLRPHPTMGSSVFIIDLGYTIWLLLGCVLAWFGRARPWAGKVLGVALLLSSGYLGWGLIAKAQVDRAAQQSLAAMGLGDAPRFSVPMPFNTLLWRVVAMTPNGYVVGDRSLVADHGPMQFEGHPSNVQALREAEGIPAVQQLQWFNRGFMRAQVVDGRLVLSDLRMGLEPDYTFNFAVAEQVDGQWRAITPEQPRVDYSSPAARADAGRRLAAMWQRIWHAPAVPSAGAAE
>NZ_AP021867.1|WP_004144220.1|762062_763061_-|glycosyltransferase-family-2-protein
MGTAQPATPAPRIAVVIPCYRVTRHVLAVLAAIDPTVTAIYCVDDACPDGSGRLIQAEASDPRVTVLFHEHNRGVGGAIKTGYRAAIADGMDILVKVDGDGQMDPALLMDFVTPIAEGHADYTKGNRFWNLTHIRRMPPVRRLGNLLLSFMTKASSGYWQVFDPTNGYTAIHARVASHLKLDAVSDRYFFETDMLFRLNTVRAVVQDVAMDAHYGDETSNLRIGRILGEFTFKHMRNTLKRIAYNYFLRDLSIASLELVAGSSLLTFGGLFGLYHWIRSAQADVATPVGTIMITMVALISGLQFLLAFVGFDIANVPRQVLNRSIKLNRAPQ
>NZ_AP021867.1|WP_012510075.1|763069_764962_-|hypothetical-protein
MDPTFENEMSDSAPTPLPAHDASLLGGLRSSQARLFAGIVALLCILYVAFALTPSSYALAYEYLGLAPQQPLLGTARYIRTDEWMVFTPYIQIAVGNDFGQVNAHSAYHESLRTFQALPLLDWGLLFKPYHWAFFLLPAANAYSFFFMFMAMAFLCGWALFLRQLRLPALAAMLVSVTLFFAPFVQVWWTSNAGAFALAPWAAVAWLRIGHRGLRIAASAYALAAWLVAVSYPPFIISSLLAMAVLVLAFRRDAITLRRLFDAAVAGAIALAVFVGYFHDIIPIVRNTVYPGQRQSAGGGVGLTTLLAHLFPNLMTYRFAPLPLFKASNDCEIAVLGSLLPLFTVVLADGARLRAWAGSHRSTLLILAAGLLLIACWIFLPIPAVVGKLTGLSMVPPARALLAFGLLLNIGCAMILVRCGVRLERWRLLLLAALLVAGSLAKFLFGEGQLSRLHSTADALPYLCLAALAIAAKRPRLSVHAASLVLATAALANLLGNGLFNPVQPAGPIFAMDRTAVLQSLQARGARNNTEGVLVAPGGFGALLPGAGIAAVNHVLYLPQLDYFGRYFPAMQDEAFNFTFNRYHHITVAADSDMPRVLQGDLVEVPANILLAAPACATPGTRDCRAGAQP
>NZ_AP021867.1|WP_153675007.1|765223_766051_-|methyltransferase-domain-containing-protein
MTPPISSPTYLHGFSGTEQQRLMTQARLLESSIFGQIDYSGARRLLEVGSGVGAQTEILLRRFPELHVTGVDLSETQLQTARENLARTPWCSDRYTLQQADAGELPFEARSFDSAFLCWVLEHVPSPARVLSEVRRVLAPGSPVYITEVMNASFLLDPYSPHIWRYWMAFNDFQYDHGGDPFVGAKLGNLLLAGGFRDVHTEIKTIYLDNREPARRKTMIAFWEQLLLSAADPLLQAGSVDEETVEGMRREFRLVQNDPNAVFFYSFVQGRATVY
>NZ_AP021867.1|WP_004144283.1|766165_767161_-|tRNA-dihydrouridine-synthase-DusB
MQIGPYSIAPNVVLAPMAGVTDKPFRLLCKRLGAGLAASEMTISDPRFWNTRKSIHRMDHDGEPAPISVQIAGTEPQQLAEAARYNVDHGAQIIDINMGCPAKKVCNAWAGSALMRDEQLVARILEAVVNAVDVPVTLKIRTGWDCDHRNGPLIARIAEDSGIAALAVHGRTRDQHYTGQAEYATIGEIKAALRIPVIANGDIDSPQKAAFVLKQTGVDAVMIGRSAQGRPWIFREVAHYLATGEELPPPSLAEVRDILLGHLHALHAFYGEPQGVRIARKHLGWYAKDRPENAAFRAVVNRAEDPASQIALTTDYFDSLIAGEPALSSAA
>NZ_AP021867.1|WP_012510077.1|767319_767751_-|hypothetical-protein
MDGFPWLLVAAAGSAIAALLHIGCIAFGAAWYQRFGAGSRVVRLAQAGHWWPPLMTAGITAVLVIWTLYALAAAGWHSPLPGSRQILSGIALLLLLRAGMGFGLALIRPGYNGARFWVTSSLACLGLGLAFALGTRQAWQALG
>NZ_AP021867.1|WP_012510078.1|767832_768750_-|LysR-family-transcriptional-regulator
MLPNERLRGIEAFVATAEAGSFTAAAERLHLTSSAVGKTVARLEARLGARLFERSTRRLRLTEAGEGFYRTCVRVLGELADAESVLAAHADAPVGRLRVDAPATFGRLKVWPLLLQLAAEFPRLRPQVTFSDRFIDLAEDGVDLAVRIGGPEPLPATLGSRLLGHECLRFCASPAYLQRHGLPTSGAELADHDGVLFGRADGSIGPWQVADGGQRSAPLQARARLVVGSAEAQVAAVEAGFGIAQLATWLVDDALARGSLVSILPALDCRGLPLRLLWPQGRQRLPRVDVALDRLGAGLRIDPPH
>NZ_AP021867.1|WP_153675008.1|768845_770033_+|MFS-transporter
MSSLDCSVATGHRAARARLSVALLAVSAFVIVTTEFLIVGLLPALARDLGLGIARAGQLVTLFAFTVMLAGPPLTALLAHLDRRRLFVAILLLFAASNALAAVATLPWLLALARVLPALALPVFWGTASETAALLAPAEQGGRAVARVYLGITAAMLFGIPLGTLAAEAIGWRGSFWLLSALSLLMAGALALWMPGTAAEPRRALGEQARVLRQPWLLGNVLLSVLVFTAMFAAYTYLADVLERLLQVPAAQVGWWLMGFGAVGLFGNALGGRWVDRAPLGATLAFCTVLALGVLASVWLAGQGGLVVIALALWGVAHTALFPLCQVRVMRAAPQAQALAGTLNVSAANAGIGLGALLGGGAIERWGLDSLGVVAAAVALLAIAAGLLLRRAEEP
>NZ_AP021867.1|WP_012510080.1|770086_771052_-|ribokinase
MSSSVVVVGSFNVDHVWRCESLPAPGATIAGRYSTGPGGKGFNQAVAACRAGADTHFVCALGDDAGGATARELAAQDGFGLIAEASSEPTGTAGIYVDARGRNTIVIGPGANAALSTDFLQQQHALLAGAKVVLVQLESPVQTIEAALATAREAGVTTVLNTAPADAPSTIGLLKLADVITPNETEFAALLGRHVGERVDANDVAALDGASLHALCRKLVGNGTVVVTLGSVGVFVSHADENLRGDTQPYYRVGAEQVQAIDTTGAGDAFNGALAASLAQVADAPFARHVRFANQFAGRSTEKEGAAAAMPRFTPADSEAK
>NZ_AP021867.1|WP_004144334.1|771077_772376_-|nucleoside-transporter-NupC
MVEGLGRIGFGLFGLAVLIGITWLFSNNKRAVDWKLVATGITLQIAFAALVILVPGGRDVFDALGHGFVKVLSFVNEGSKFIFGSLMDVKNYGFIFAFQVLPTIIFFSALMGVMYHLNVMQGIVRVMAWSITKVMRVSGAETTSVCASVFIGQTEAPLTVRPYIAKMTQSELLTMMIGGMAHIAGGVLAAYVGMLGGGDPVQQAFYAKHLLAASIMAAPATLVVAKLLIPETGTPLTRGTVKMEVEKTSSNIIDAAAAGAGDGLKLALNIGAMLLAFIALIALLNAPLTWIGEVTGLAAQIGKPTNLSTIFGYVLAPIAWVIGTPWADATTVGSLIGQKVVINEFVAYTELSQIVNGQVAGVSLSDEGRLIATYALCGFANFSSIAIQIGGIGGLAPERRHDLAKFGLRAVLGGTIATFMTATIAGVLTHFS

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Crispr_ID: NZ_AP021867_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP021867_2

773574-773660

Orphan

Consensus_repeat	Method
GCTCGACTCCGCGCGCAGCGCGGGTTTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP021867_2

>merge|NZ_AP021867|2|773574-773660|CRISPRCasFinder
GCTCGACTCCGCGCGCAGCGCGGGTTTCCAGGATCGCCGCCTCTGTAGAGTCGAGCCGTGCTCGACTCCGCGCGCAGCGCGGGTTTC

>NZ_AP021867|2|2|773574-773660|CRISPRCasFinder
GCTCGACTCCGCGCGCAGCGCGGGTTTC	CAGGATCGCCGCCTCTGTAGAGTCGAGCCGT
GCTCGACTCCGCGCGCAGCGCGGGTTTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP021867.1\|WP_153675009.1\|772570_773542_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381369
NZ_AP021867.1\|WP_153675012.1\|778301_778832_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_153675008.1\|768845_770033_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
NZ_AP021867.1\|WP_032968719.1\|774237_776445_+\|TonB-dependent-hemoglobin/transferrin/lactoferrin-family-receptor	unknown	unknown	gnl\|CDD\|273808
NZ_AP021867.1\|WP_005412278.1\|773853_774048_+\|hemin-uptake-protein-HemP	unknown	unknown	gnl\|CDD\|378463
NZ_AP021867.1\|WP_153675007.1\|765223_766051_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|181382
NZ_AP021867.1\|WP_004144283.1\|766165_767161_-\|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl\|CDD\|129820
NZ_AP021867.1\|WP_153675013.1\|779935_782452_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|225669
NZ_AP021867.1\|WP_004144220.1\|762062_763061_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133022
NZ_AP021867.1\|WP_100434061.1\|779341_779905_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_004144334.1\|771077_772376_-\|nucleoside-transporter-NupC	unknown	unknown	gnl\|CDD\|224883
NZ_AP021867.1\|WP_065722802.1\|783171_783816_+\|arylesterase	unknown	unknown	gnl\|CDD\|238860
NZ_AP021867.1\|WP_153675011.1\|777121_778048_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_012510087.1\|782448_783096_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|226647
NZ_AP021867.1\|WP_004144371.1\|778831_779116_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_012510077.1\|767319_767751_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_153675010.1\|776449_777049_+\|Hemin-transport-protein	unknown	unknown	gnl\|CDD\|226243
NZ_AP021867.1\|WP_012510078.1\|767832_768750_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176164
NZ_AP021867.1\|WP_012510080.1\|770086_771052_-\|ribokinase	unknown	unknown	gnl\|CDD\|238579
NZ_AP021867.1\|WP_012510075.1\|763069_764962_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|287142

Protein	Function_ID	Function_description	E-value
NZ_AP021867.1\|WP_153675009.1\|772570_773542_+\|aldo/keto-reductase	gnl\|CDD\|381369	cd19143, AKR_AKR6C1_2, AKR6C family of aldo-keto reductase (AKR). Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.	0
NZ_AP021867.1\|WP_153675008.1\|768845_770033_+\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	8.64272e-71
NZ_AP021867.1\|WP_005412278.1\|773853_774048_+\|hemin-uptake-protein-HemP	gnl\|CDD\|378463	pfam10636, hemP, Hemin uptake protein hemP. This is a bacterial family of proteins that are involved in the uptake of the iron source hemin.	2.47066e-16
NZ_AP021867.1\|WP_153675007.1\|765223_766051_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|181382	PRK08317, PRK08317, hypothetical protein; Provisional.	5.07027e-26
NZ_AP021867.1\|WP_004144283.1\|766165_767161_-\|tRNA-dihydrouridine-synthase-DusB	gnl\|CDD\|129820	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family. This model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). This branch includes NifR3 itself, from Rhodobacter capsulatus. It excludes a broadly distributed but more sparsely populated subfamily that contains sll0926 from Synechocystis PCC6803, HI0634 from Haemophilus influenzae, and BB0225 from Borrelia burgdorferi. It also excludes a shorter and more distant archaeal subfamily.The function of nifR3, a member of this family, is unknown, but it is found in an operon with nitrogen-sensing two component regulators in Rhodobacter capsulatus.Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase. [Unknown function, General].	5.11867e-148
NZ_AP021867.1\|WP_153675013.1\|779935_782452_-\|FtsX-like-permease-family-protein	gnl\|CDD\|225669	COG3127, COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	9.97075e-180
NZ_AP021867.1\|WP_004144220.1\|762062_763061_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|133022	cd04179, DPM_DPG-synthase_like, DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.	1.29033e-43
NZ_AP021867.1\|WP_065722802.1\|783171_783816_+\|arylesterase	gnl\|CDD\|238860	cd01822, Lysophospholipase_L1_like, Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity.	8.89291e-85
NZ_AP021867.1\|WP_004144334.1\|771077_772376_-\|nucleoside-transporter-NupC	gnl\|CDD\|224883	COG1972, NupC, Nucleoside permease [Nucleotide transport and metabolism].	2.63974e-142
NZ_AP021867.1\|WP_012510087.1\|782448_783096_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|226647	COG4181, COG4181, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism].	3.59701e-98
NZ_AP021867.1\|WP_032968719.1\|774237_776445_+\|TonB-dependent-hemoglobin/transferrin/lactoferrin-family-receptor	gnl\|CDD\|273808	TIGR01786, hemoglobin-haptoglobin-binding_protein, TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein. This model represents a family of TonB-dependent outer membrane receptor/transporters acting on iron-containing proteins such as hemoglobin, transferrin and lactoferrin. Two subfamily models with a narrower scope are contained within this model, the heme/hemoglobin receptor family protein model (TIGR01785) and the transferrin/lactoferrin receptor family model (TIGR01776). Accessions which score above trusted to this model while not scoring above trusted to the more specific models are most likely to be hemoglobin transporters. Nearly all of the species containing trusted hits to this model have access to hemoglobin, transferrin or lactoferrin or related proteins in their biological niche. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins].	1.55742e-125
NZ_AP021867.1\|WP_153675010.1\|776449_777049_+\|Hemin-transport-protein	gnl\|CDD\|226243	COG3720, HemS, Putative heme degradation protein [Inorganic ion transport and metabolism].	0.0016058
NZ_AP021867.1\|WP_012510078.1\|767832_768750_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176164	cd08475, PBP2_CrgA_like_6, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 6. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.06125e-83
NZ_AP021867.1\|WP_012510080.1\|770086_771052_-\|ribokinase	gnl\|CDD\|238579	cd01174, ribokinase, Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides and histidine, and for entry into the pentose phosphate pathway. Ribokinase is dimeric in solution.	7.69446e-100
NZ_AP021867.1\|WP_012510075.1\|763069_764962_-\|hypothetical-protein	gnl\|CDD\|287142	pfam10131, PTPS_related, 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein. This domain is found in various bacterial hypothetical membrane proteins, as well as in tetratricopeptide TPR_2 repeat protein. The exact function of the domain has not, as yet, been established.	0.00515049

>NZ_AP021867.1|WP_153675009.1|772570_773542_+|aldo/keto-reductase
MQYRRLGSTGLPISALSFGAWVTFGDQIPRDEARNLVAAAWDHGVNFFDNAEGYANGRAEQVMGDVITDLRLPRDGFCVSSKVFFGSAKDPRPTQRGLSRKHVTDACHAALKRLRVDYLDLYYCHRPDPDAPIAETVHAMDTLVRQGKILYWGTSEWSAAQIQQALDIAEAHNLQGPSMEQPQYNLLHRERVEVEYAPLYAGAGLGTTIFSPLASGLLSGKYDQGIPADARLGREGMEWLQDLVLGADAEARLAQVRRFSEVARSLGHAPATLAIAWCLRNPNVSSVILGASRVSQLLQNLQALDVLEQVDAAGWAQLEAIFA
>NZ_AP021867.1|WP_004144334.1|771077_772376_-|nucleoside-transporter-NupC
MVEGLGRIGFGLFGLAVLIGITWLFSNNKRAVDWKLVATGITLQIAFAALVILVPGGRDVFDALGHGFVKVLSFVNEGSKFIFGSLMDVKNYGFIFAFQVLPTIIFFSALMGVMYHLNVMQGIVRVMAWSITKVMRVSGAETTSVCASVFIGQTEAPLTVRPYIAKMTQSELLTMMIGGMAHIAGGVLAAYVGMLGGGDPVQQAFYAKHLLAASIMAAPATLVVAKLLIPETGTPLTRGTVKMEVEKTSSNIIDAAAAGAGDGLKLALNIGAMLLAFIALIALLNAPLTWIGEVTGLAAQIGKPTNLSTIFGYVLAPIAWVIGTPWADATTVGSLIGQKVVINEFVAYTELSQIVNGQVAGVSLSDEGRLIATYALCGFANFSSIAIQIGGIGGLAPERRHDLAKFGLRAVLGGTIATFMTATIAGVLTHFS
>NZ_AP021867.1|WP_012510080.1|770086_771052_-|ribokinase
MSSSVVVVGSFNVDHVWRCESLPAPGATIAGRYSTGPGGKGFNQAVAACRAGADTHFVCALGDDAGGATARELAAQDGFGLIAEASSEPTGTAGIYVDARGRNTIVIGPGANAALSTDFLQQQHALLAGAKVVLVQLESPVQTIEAALATAREAGVTTVLNTAPADAPSTIGLLKLADVITPNETEFAALLGRHVGERVDANDVAALDGASLHALCRKLVGNGTVVVTLGSVGVFVSHADENLRGDTQPYYRVGAEQVQAIDTTGAGDAFNGALAASLAQVADAPFARHVRFANQFAGRSTEKEGAAAAMPRFTPADSEAK
>NZ_AP021867.1|WP_153675008.1|768845_770033_+|MFS-transporter
MSSLDCSVATGHRAARARLSVALLAVSAFVIVTTEFLIVGLLPALARDLGLGIARAGQLVTLFAFTVMLAGPPLTALLAHLDRRRLFVAILLLFAASNALAAVATLPWLLALARVLPALALPVFWGTASETAALLAPAEQGGRAVARVYLGITAAMLFGIPLGTLAAEAIGWRGSFWLLSALSLLMAGALALWMPGTAAEPRRALGEQARVLRQPWLLGNVLLSVLVFTAMFAAYTYLADVLERLLQVPAAQVGWWLMGFGAVGLFGNALGGRWVDRAPLGATLAFCTVLALGVLASVWLAGQGGLVVIALALWGVAHTALFPLCQVRVMRAAPQAQALAGTLNVSAANAGIGLGALLGGGAIERWGLDSLGVVAAAVALLAIAAGLLLRRAEEP
>NZ_AP021867.1|WP_012510078.1|767832_768750_-|LysR-family-transcriptional-regulator
MLPNERLRGIEAFVATAEAGSFTAAAERLHLTSSAVGKTVARLEARLGARLFERSTRRLRLTEAGEGFYRTCVRVLGELADAESVLAAHADAPVGRLRVDAPATFGRLKVWPLLLQLAAEFPRLRPQVTFSDRFIDLAEDGVDLAVRIGGPEPLPATLGSRLLGHECLRFCASPAYLQRHGLPTSGAELADHDGVLFGRADGSIGPWQVADGGQRSAPLQARARLVVGSAEAQVAAVEAGFGIAQLATWLVDDALARGSLVSILPALDCRGLPLRLLWPQGRQRLPRVDVALDRLGAGLRIDPPH
>NZ_AP021867.1|WP_012510077.1|767319_767751_-|hypothetical-protein
MDGFPWLLVAAAGSAIAALLHIGCIAFGAAWYQRFGAGSRVVRLAQAGHWWPPLMTAGITAVLVIWTLYALAAAGWHSPLPGSRQILSGIALLLLLRAGMGFGLALIRPGYNGARFWVTSSLACLGLGLAFALGTRQAWQALG
>NZ_AP021867.1|WP_004144283.1|766165_767161_-|tRNA-dihydrouridine-synthase-DusB
MQIGPYSIAPNVVLAPMAGVTDKPFRLLCKRLGAGLAASEMTISDPRFWNTRKSIHRMDHDGEPAPISVQIAGTEPQQLAEAARYNVDHGAQIIDINMGCPAKKVCNAWAGSALMRDEQLVARILEAVVNAVDVPVTLKIRTGWDCDHRNGPLIARIAEDSGIAALAVHGRTRDQHYTGQAEYATIGEIKAALRIPVIANGDIDSPQKAAFVLKQTGVDAVMIGRSAQGRPWIFREVAHYLATGEELPPPSLAEVRDILLGHLHALHAFYGEPQGVRIARKHLGWYAKDRPENAAFRAVVNRAEDPASQIALTTDYFDSLIAGEPALSSAA
>NZ_AP021867.1|WP_153675007.1|765223_766051_-|methyltransferase-domain-containing-protein
MTPPISSPTYLHGFSGTEQQRLMTQARLLESSIFGQIDYSGARRLLEVGSGVGAQTEILLRRFPELHVTGVDLSETQLQTARENLARTPWCSDRYTLQQADAGELPFEARSFDSAFLCWVLEHVPSPARVLSEVRRVLAPGSPVYITEVMNASFLLDPYSPHIWRYWMAFNDFQYDHGGDPFVGAKLGNLLLAGGFRDVHTEIKTIYLDNREPARRKTMIAFWEQLLLSAADPLLQAGSVDEETVEGMRREFRLVQNDPNAVFFYSFVQGRATVY
>NZ_AP021867.1|WP_012510075.1|763069_764962_-|hypothetical-protein
MDPTFENEMSDSAPTPLPAHDASLLGGLRSSQARLFAGIVALLCILYVAFALTPSSYALAYEYLGLAPQQPLLGTARYIRTDEWMVFTPYIQIAVGNDFGQVNAHSAYHESLRTFQALPLLDWGLLFKPYHWAFFLLPAANAYSFFFMFMAMAFLCGWALFLRQLRLPALAAMLVSVTLFFAPFVQVWWTSNAGAFALAPWAAVAWLRIGHRGLRIAASAYALAAWLVAVSYPPFIISSLLAMAVLVLAFRRDAITLRRLFDAAVAGAIALAVFVGYFHDIIPIVRNTVYPGQRQSAGGGVGLTTLLAHLFPNLMTYRFAPLPLFKASNDCEIAVLGSLLPLFTVVLADGARLRAWAGSHRSTLLILAAGLLLIACWIFLPIPAVVGKLTGLSMVPPARALLAFGLLLNIGCAMILVRCGVRLERWRLLLLAALLVAGSLAKFLFGEGQLSRLHSTADALPYLCLAALAIAAKRPRLSVHAASLVLATAALANLLGNGLFNPVQPAGPIFAMDRTAVLQSLQARGARNNTEGVLVAPGGFGALLPGAGIAAVNHVLYLPQLDYFGRYFPAMQDEAFNFTFNRYHHITVAADSDMPRVLQGDLVEVPANILLAAPACATPGTRDCRAGAQP
>NZ_AP021867.1|WP_004144220.1|762062_763061_-|glycosyltransferase-family-2-protein
MGTAQPATPAPRIAVVIPCYRVTRHVLAVLAAIDPTVTAIYCVDDACPDGSGRLIQAEASDPRVTVLFHEHNRGVGGAIKTGYRAAIADGMDILVKVDGDGQMDPALLMDFVTPIAEGHADYTKGNRFWNLTHIRRMPPVRRLGNLLLSFMTKASSGYWQVFDPTNGYTAIHARVASHLKLDAVSDRYFFETDMLFRLNTVRAVVQDVAMDAHYGDETSNLRIGRILGEFTFKHMRNTLKRIAYNYFLRDLSIASLELVAGSSLLTFGGLFGLYHWIRSAQADVATPVGTIMITMVALISGLQFLLAFVGFDIANVPRQVLNRSIKLNRAPQ
>NZ_AP021867.1|WP_005412278.1|773853_774048_+|hemin-uptake-protein-HemP
MNAQPVLLRPETLTLRDRPVRVVPPEEVIDSEALLKGRREILIQHGDRFYRLRHTSNDKLILTK
>NZ_AP021867.1|WP_032968719.1|774237_776445_+|TonB-dependent-hemoglobin/transferrin/lactoferrin-family-receptor
MALPLSAHAAAAAAPDAREFDRVQVTATRTERAVSDVAATVDVIDREQMDRHLVQDIKDLVRYEPGLSVTRSATRFGLDGFRIRGLDGNRVRIQTDGIVMPTRFDIGSFASSNRNFTDLDTLKRVEIVRGPASSLYGSDALGGVVAFVTKDPADYLKDGKNSYFGLKFGYDGEWKGLLGGATAAFGGEHWSGLVNVNHHQGQETDNKGTVRSDNDTRTASNPQDRDGRSLLSKLVYAPSEDQRFRLTVEGNEDTTDTNVLSAIASVAPRPGAMAAATGMKSHDTQKRNRVSFAHEMDALDQPFADSLHWQVYAQNSETRQQTDETRTDGSRRHRVFSFDQHAYGLQAQFNKAFSTGAVEHALTYGFEGTRTEIRQKRDGYQVNRAGVVSNTVTPDTFPVRDFPISKTTELGLYAQDEMRLADGKLSLVPGVRVDRYELKPEVDSIFAEDNPTTAVAQLKKTSVSPKLGMVWRFTDEWSLFAGYARGFRSPPYNDVNIGLTNVAFGYTAIANPDLKPETSDGYELGLRFIAPAAYVSVSGYYNDYKDFIESNVNTGRNAQGLMVFQSQNIADARIYGAEMKAGIEFGELSPALKGWALRSALAWSRGDNKTDDEPLASVDPLRGTLGLMYDTDTWGVELAGTFVQRKKHLPPPAAQTNPNAPAPFVYQPAGYGVLDLMAHWNFAPGATFNVGVFNLADKRYIEWSSITPSLITNRALSDRFSSPGRTFSASLAVSW
>NZ_AP021867.1|WP_153675010.1|776449_777049_+|Hemin-transport-protein
MSRALSARRNDSIAVPNSTAWPTPAQLATLGTVLCLYHAGGNELGGWRQAVRVHACQGVDSEGLRESLCFLDGRGRCVWRLYLLPDSDFLAWDRLVAALPPGPEHDSDASVGERLWRRLAGHLGGQRWRLCALRLHAADDGRTLAASLSTLSSLGAATARRIARLESAEGELAIDDCCCADAARRPTPRVPGDLPLIRL
>NZ_AP021867.1|WP_153675011.1|777121_778048_+|hypothetical-protein
MKLQTASVMLLLAASGVASAQPSDIARDHDSILAMQGEYTVDFAFDETVLLKPGYERAPAMRSGGNEVVIVVEDTPKRIVLQHLLLDEKSGHITKHWRQDWVYEAPNRFEFSADQTWKVRSIPAAVNQGAWTQCVYEVSDAPRYCGTGTWTYTNNVPSWTSDLSWRPLPRREYTKRSDYNALAVINRHTLTPNGWTHEQFNTKVQRNADGSQVEIAREFGFNDYVKTTEVDFTPARNYWKATAGYWAKVRQRWDGFLGQAPGVHLKTKIDGMAMIIPMFTQAEEIQAGKKVKDKQIDDVFAKYVEKAQ
>NZ_AP021867.1|WP_153675012.1|778301_778832_+|hypothetical-protein
MKLSELCSQLLSGEACDDIDSFHLEIDDFEELELVSRLSRIDGVLERLGPRWTSAYLLSLCNHVLSTVRISGSARDSADAKMFLALSFTDFELHAQEGILLPSVFYYPGPEGAAFGSHRRHESDRAASAEIDIVRSVFEDAGMIAGFRFCESRTDGPPGHDVVRVFAIPSFENEVR
>NZ_AP021867.1|WP_004144371.1|778831_779116_+|hypothetical-protein
MLVEERQVFETYLSDPQVCDRLEQHFLDAFTAGIQAANLRAEDFRSPHYNVFFVDGTKDREANPIFSAKHMISGNIVRIVIFESPPDYTEVHNR
>NZ_AP021867.1|WP_100434061.1|779341_779905_-|hypothetical-protein
MLRAPPDQIVRKRNLVHRAPDVQGMKMKYGVCLRILLASSPLLTAVLPAGARAAEGYVPDAVQAFVLETVLADEAQAFHEGHPTYLVPASVSRTRSDADVVADLRTEFDRFYRGQPKPRKEVAHMAILVAQTALLLPDRSACSTDRVRCHQAVMGVRTRDDEASLQATLRAFQDAGLDLTTLGEKAS
>NZ_AP021867.1|WP_153675013.1|779935_782452_-|FtsX-like-permease-family-protein
MNLLRHAWRALRREALAGDLLTVFAALVLGVAVMTAVGTLVNRVNLALTGSAAEMLGGDLGIAGRDDPPQAFADEAQRRGLSYTRIASFGSVLFNGDASQMASIKAVQAGYPLRGTLRVRATPGGALIDNAGMPAKGQAYADPRLLQGLGLKAGDDLEFGAGTLRIAGIIEAEPDTGGDLLTLSPTLLVNRADVEGTGLLGPGSRINYRLMFAGPADQVAALRQWLLPQVKGLRLLSVDDTQRGVRQAFDLAGRFLGLSALLAVLLAGVATALAANRFALRRIDQVAILRCLGARQRDILSGLALQLLMLAVPACALGIALGMAAQEGLVQVLGSLVPQRLPLPEAMPALTGAGIGLLLLFGFGLPPLLRLRGVPPMRVLNRSFAALPPASLLAYVAALAASLLLAVQVTGDLKLALWVLGGLAALAVAAGVVGFVLLQLLRGLQHRLHGNWRLGLAALTRRRMLAVMQLVGLSLSLCALLLLAVTGPGLLQQWRERLPADTPNYFLINIQPEQRDNVLAALRGLGANDASIEPMATGRLIAINGKPPLRVDRSPEQSGQPASGEGQRDDDDENRPLNFSWRSSFPPANTLVNGTFWKADSTAAEASVEIGWAKRYGVYPGDRITIAVGEQEREFTVTSVRKADWNTFRPNFFVLLNPNAVGDTPHNLLSAFHLPAGKAAGLGELVRAQPNLSLLDVDAVISQVRDVMERVAQAVQLVMVFSLLAGVLVLLAALQATAGERRYDSAVLRTLGATRRQLRGAVLVEFGALGTLAALLAVGAAAAIGVAVSQKVFELPLLPPWPGLLIGGVVGIGLSLLAGWWGTRAILHTPPALALREA
>NZ_AP021867.1|WP_012510087.1|782448_783096_-|ATP-binding-cassette-domain-containing-protein
MQGPEGEVHILDNITLTVHEGTSVAIVGASGSGKTTLLGLLAGLDLPSRGSIALAGQDLAALDEEARAQLRAREVGFVFQSFHLLPALTAAENVALPLELAGREDRARVDEVLAQVGLGHRARHYPRQLSGGEQQRVALARAFVTRPRILFADEPTGSLDHATGQHISDLLFELNAGSGTTLVLVTHDLRLAQRCQYIHRIDDGRLLPVERGAQA
>NZ_AP021867.1|WP_065722802.1|783171_783816_+|arylesterase
MRKTGWSRRAGAMMVLLLGLLLLPGLASAKGPVGTVLVLGDSLSAAHNIPADAGWVSLLQQRVRQQSKTPARIVNASMSGETTAGALTRLPGLLAKEKPTVVVIALGGNDALRGLTPAQVQGNLEKMVQASQKAGAKVLLLGIDVPPNYGAGYRQRLAAAYKALATQYKVPLLPFLLEGVALQPGLMQADGLHPTAQAQPKVLDNVWPLLRPLL

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Crispr_ID: NZ_AP021867_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP021867_3

1079612-1079743

Orphan

Consensus_repeat	Method
GGTGGGTGCCGACCGTTGGTCGGCAC	PILER-CR
GGTGGGTGCCGACCGTTGGTCGGCAC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_AP021867_3

>merge|NZ_AP021867|3|1079612-1079743|PILER-CR,CRISPRCasFinder
GGTGGGTGCCGACCGTTGGTCGGCACAAAAGGGATTCACCCTGAACTGTCTGGGTGGGTGGGTGCCGACCGTTGGTCTGCACGGTTGATCTGTCCTTATCCGATCCGGTGGGTGCCGACCGTTGGTCGGCAC

>NZ_AP021867|3|1|1079612-1079743|PILER-CR
GGTGGGTGCCGACCGTTGGTCGGCAC	AAAAGGGATTCACCCTGAACTGTCTGGGTG
GGTGGGTGCCGACCGTTGGTCTGCAC	GGTTGATCTGTCCTTATCCGATCC
GGTGGGTGCCGACCGTTGGTCGGCAC

>NZ_AP021867|3|3|1079612-1079743|CRISPRCasFinder
GGTGGGTGCCGACCGTTGGTCGGCAC	AAAAGGGATTCACCCTGAACTGTCTGGGTG
GGTGGGTGCCGACCGTTGGTCTGCAC	GGTTGATCTGTCCTTATCCGATCC
GGTGGGTGCCGACCGTTGGTCGGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP021867.1\|WP_100434157.1\|1085241_1085634_-\|PTS-fructose-IIA-subunit-family-protein	unknown	unknown	gnl\|CDD\|225446
NZ_AP021867.1\|WP_004147235.1\|1081665_1083027_-\|magnesium-transporter	unknown	unknown	gnl\|CDD\|225148
NZ_AP021867.1\|WP_046983647.1\|1084979_1085249_-\|HPr-family-phosphocarrier-protein	unknown	unknown	gnl\|CDD\|273389
NZ_AP021867.1\|WP_100434158.1\|1085937_1086822_-\|RNase-adapter-RapZ	unknown	unknown	gnl\|CDD\|235450
NZ_AP021867.1\|WP_004147181.1\|1078653_1079604_+\|aspartate-carbamoyltransferase-catalytic-subunit	unknown	unknown	gnl\|CDD\|234849
NZ_AP021867.1\|WP_012510275.1\|1074385_1075093_+\|YitT-family-protein	unknown	unknown	gnl\|CDD\|224203
NZ_AP021867.1\|WP_100434159.1\|1087798_1088251_-\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|334031
NZ_AP021867.1\|WP_012510273.1\|1073536_1073746_+\|DUF4287-domain-containing-protein	unknown	unknown	gnl\|CDD\|379478
NZ_AP021867.1\|WP_012510274.1\|1073842_1074292_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_AP021867.1\|WP_100434156.1\|1080469_1081267_-\|prolyl-oligopeptidase-family-serine-peptidase	unknown	unknown	gnl\|CDD\|226584
NZ_AP021867.1\|WP_004147177.1\|1077584_1078151_+\|YqgE/AlgH-family-protein	unknown	unknown	gnl\|CDD\|234694
NZ_AP021867.1\|WP_174238317.1\|1078170_1078638_+\|Holliday-junction-resolvase-RuvX	unknown	unknown	gnl\|CDD\|234639
NZ_AP021867.1\|WP_004147103.1\|1071504_1072488_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381304
NZ_AP021867.1\|WP_012510280.1\|1083207_1084977_-\|phosphoenolpyruvate--protein-phosphotransferase	unknown	unknown	gnl\|CDD\|224006
NZ_AP021867.1\|WP_005408388.1\|1086851_1087802_-\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
NZ_AP021867.1\|WP_100434155.1\|1079857_1080349_+\|transposase	unknown	unknown	gnl\|CDD\|376616
NZ_AP021867.1\|WP_097048709.1\|1075166_1075709_-\|DNA-3-methyladenine-glycosylase-I	unknown	unknown	gnl\|CDD\|225374
NZ_AP021867.1\|WP_153675053.1\|1072543_1073443_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176163
NZ_AP021867.1\|WP_153675054.1\|1075705_1077493_-\|DUF4153-domain-containing-protein	unknown	unknown	gnl\|CDD\|372672
NZ_AP021867.1\|WP_065722565.1\|1081337_1081604_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP021867.1\|WP_100434157.1\|1085241_1085634_-\|PTS-fructose-IIA-subunit-family-protein	gnl\|CDD\|225446	COG2893, ManX, Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism].	8.09762e-26
NZ_AP021867.1\|WP_004147235.1\|1081665_1083027_-\|magnesium-transporter	gnl\|CDD\|225148	COG2239, MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism].	8.63344e-162
NZ_AP021867.1\|WP_046983647.1\|1084979_1085249_-\|HPr-family-phosphocarrier-protein	gnl\|CDD\|273389	TIGR01003, Phosphocarrier_protein_HPr, Phosphotransferase System HPr (HPr) Family. The HPr family are bacterial proteins (or domains of proteins) which function in phosphoryl transfer system (PTS) systems. They include energy-coupling components which catalyze sugar uptake via a group translocation mechanism. The functions of most of these proteins are not known, but they presumably function in PTS-related regulatory capacities. All seed members are stand-alone HPr proteins, although the model also recognizes HPr domains of PTS fusion proteins. This family includes the related NPr protein. [Signal transduction, PTS].	1.08365e-31
NZ_AP021867.1\|WP_004147181.1\|1078653_1079604_+\|aspartate-carbamoyltransferase-catalytic-subunit	gnl\|CDD\|234849	PRK00856, pyrB, aspartate carbamoyltransferase catalytic subunit.	4.99638e-164
NZ_AP021867.1\|WP_012510275.1\|1074385_1075093_+\|YitT-family-protein	gnl\|CDD\|224203	COG1284, COG1284, Uncharacterized conserved protein [Function unknown].	3.19432e-40
NZ_AP021867.1\|WP_100434159.1\|1087798_1088251_-\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|334031	pfam00359, PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2.	9.99625e-33
NZ_AP021867.1\|WP_012510273.1\|1073536_1073746_+\|DUF4287-domain-containing-protein	gnl\|CDD\|379478	pfam14117, DUF4287, Domain of unknown function (DUF4287). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 70 and 180 amino acids in length.	1.34988e-24
NZ_AP021867.1\|WP_012510274.1\|1073842_1074292_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	9.44494e-13
NZ_AP021867.1\|WP_100434156.1\|1080469_1081267_-\|prolyl-oligopeptidase-family-serine-peptidase	gnl\|CDD\|226584	COG4099, COG4099, Predicted peptidase [General function prediction only].	1.46567e-34
NZ_AP021867.1\|WP_004147177.1\|1077584_1078151_+\|YqgE/AlgH-family-protein	gnl\|CDD\|234694	PRK00228, PRK00228, YqgE/AlgH family protein.	3.07451e-85
NZ_AP021867.1\|WP_174238317.1\|1078170_1078638_+\|Holliday-junction-resolvase-RuvX	gnl\|CDD\|234639	PRK00109, PRK00109, Holliday junction resolvase RuvX.	7.12446e-51
NZ_AP021867.1\|WP_004147103.1\|1071504_1072488_+\|aldo/keto-reductase	gnl\|CDD\|381304	cd19078, AKR_AKR13C1_2, AKR13C family of aldo-keto reductase (AKR). The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.	0
NZ_AP021867.1\|WP_012510280.1\|1083207_1084977_-\|phosphoenolpyruvate--protein-phosphotransferase	gnl\|CDD\|224006	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism].	0
NZ_AP021867.1\|WP_005408388.1\|1086851_1087802_-\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	1.55323e-139
NZ_AP021867.1\|WP_100434155.1\|1079857_1080349_+\|transposase	gnl\|CDD\|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	3.00511e-10
NZ_AP021867.1\|WP_097048709.1\|1075166_1075709_-\|DNA-3-methyladenine-glycosylase-I	gnl\|CDD\|225374	COG2818, Tag, 3-methyladenine DNA glycosylase [DNA replication, recombination, and repair].	3.15603e-60
NZ_AP021867.1\|WP_153675053.1\|1072543_1073443_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176163	cd08474, PBP2_CrgA_like_5, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 5. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.09466e-103
NZ_AP021867.1\|WP_153675054.1\|1075705_1077493_-\|DUF4153-domain-containing-protein	gnl\|CDD\|372672	pfam13687, DUF4153, Domain of unknown function (DUF4153). Members of this family are annotated as putative inner membrane proteins.	4.10571e-14
NZ_AP021867.1\|WP_100434158.1\|1085937_1086822_-\|RNase-adapter-RapZ	gnl\|CDD\|235450	PRK05416, PRK05416, RNase adapter RapZ.	3.72184e-146

>NZ_AP021867.1|WP_004147181.1|1078653_1079604_+|aspartate-carbamoyltransferase-catalytic-subunit
MTAQQLDASGRLRHLLTLEGLPRETLLQLLDRAGQIRDAAVGRVGNKRQVLAGSAVCTLFFEPSTRTRSSFQLAAQRLGADVLNFDASTSSTRKGETACDTLRNLEAMGVRGFVVRHPDDGAVAALAEAAGEGTALINAGDGRSAHPTQGLLDMLTLRQAKGPDFSKMKVVIVGDVKHSRVARTDLHALRTLGVGEIRVCGPQSLLPDDETLKGCVVGDDFDAMLEGVDALMMLRLQRERMEEGLVPSLEQYHAQYGLTNERLARAGKDAAVLHPGPINRGVEVTDEVADGPQSWVLRQVANGVAVRMAVLETLLG
>NZ_AP021867.1|WP_174238317.1|1078170_1078638_+|Holliday-junction-resolvase-RuvX
MSAAPAIRRDGTVLGFDVGSRRIGVAIGSAFAAHARAVAVVDVHGNGPDWTAIERLIKEWKPDGLVVGDPLTLDGQDQPNRKRAQGFARQLRERFKLPVVMIDERSSSVEAARRFAVERAEGRKRRRDAAALDAVAAAVIIDRWLSSPDDAIPIP
>NZ_AP021867.1|WP_004147177.1|1077584_1078151_+|YqgE/AlgH-family-protein
MPVTPTSLADHLLVALPSLLDATFARSVALICQHDENGAMGVLVNQPSEYTLGEVLAQMDITTGDGDLQARMVLNGGPVHPERGFVIHDDARAWDSSLIVGEGLYLTTSRDILEAMARGEGPANAVVTLGCAGWGAGQLESELSENSWLTVPADAELVFQLPLEQRWQGAASRIGVDLFRLTDYSGHV
>NZ_AP021867.1|WP_153675054.1|1075705_1077493_-|DUF4153-domain-containing-protein
MQSSSPLTLPARSAIVLIALLQGLMLYAAQELSDAWPFRDIGWRYCWYAWVLAIPSAVALSLVDLGQRRLWLQAMLGSAVVLALAAWIGWNLNGETALESGALQFPLTLGMAVAVFVALPWWQFQLQHGHWRASYPELFERAWQNGLTLALAALFTGLTWLLLWLWAALFQLLDVTFFRDLFRQDAFIALATGSLAGFGVLIGRTQHRAIQITRQVLFAICRGLLPLLSFIAVLFVLSLPLTGLEPLWKTRSAASLLLVLSLLLVSFTNAVYQQGDDTAPYPLLLRRLVEASLLALPVYAVLALYALGLRVVQYGWTLDRFWAVLIALAVAGYALGYALAVVRRRGRWLQTLEPVNRWMCWAVLALALLGNSPLLDPVRLTLSSQLARLRADPPAITSSDVNVLRFDLGHRGVQALRELQDDPAIIADANAPQVIADALARTSRWDGGTRLDKGPQDIAALQRALKLAKGSSSPPDDWWQALATRAINGESCAQSERDCLIVHRDLDGDGSAEVLLCELYNIRGPDCVLYARGKDTRWHRAGSLFGAASGQAEAINQALRDGKLTLVPPRWPMLSIGGHLAVAIDPEPESNESSP
>NZ_AP021867.1|WP_097048709.1|1075166_1075709_-|DNA-3-methyladenine-glycosylase-I
MSGYCLIAPGHPVHDYYHANEYGFPQRDERELFERLVLEINQAGLSWETILKKREGFRAAYDGFDVDRVAAYAEQDIERLLSDAGIIRNRLKVLAAIHNAQVIQQLRASHGSFAGWLDAHHPRSKADWVKLFKKTFRFTGGEITGEFLMSLGYLPGAHAEDCPVHARLLTLSPPWLQASR
>NZ_AP021867.1|WP_012510275.1|1074385_1075093_+|YitT-family-protein
MSLPAHGSAPCDDADGHLVTAGPLTPPPDSAGTTADEKALRHSIAEDVQGMVLATMVASLGLAIFAKGGLMIGGMAGMAFLLHYSMGWNFGLVFVLVNLPFYWVALRRMGWEFTLKTFAAVTACGVLTDLLPRWIDFSHINPLYSAIVGGALSGLGILFFIRHRASLGGIGILAVYLQRTRGWSAGKVQMSYDACLMVAAFFVLSPSKVLYSAIGAVVLSLVLMFNHRPGRYMGV
>NZ_AP021867.1|WP_012510274.1|1073842_1074292_+|GNAT-family-N-acetyltransferase
MQVTLDAITVDNYEAVCDLDVSEAQQDFVAGNTWSLVQAAFHPGYQTRAIQADGELVGFFMWVPETPQRISIWRFMVDQRWQGRGIGRRALELALAQIRDTPGLAEIEICYNPHNPVAGAFYGSFGFVETGMDDDGEDMLAVLPVTPPK
>NZ_AP021867.1|WP_012510273.1|1073536_1073746_+|DUF4287-domain-containing-protein
MSTEKPKGPASYFPSIEKTYGQPVTHWFGLLAKQPGLKHMELVSFLKSEHGLGHGHANALVAHHLAGKG
>NZ_AP021867.1|WP_153675053.1|1072543_1073443_-|LysR-family-transcriptional-regulator
MPRENLNDLQAFVHVAREGSFTRAAAQLGVSQSALSHAMRGLEERLGVRLLTRTTRSVSTTEAGARLLDTLAPRLAEIEDELAALAEYRERPAGTIRINATGHAAEYIAWPRLAPLLQQYPDLKVELAADYGLADIVAERYDIGIRLGERLARDMIAVPVSPPLRMRVVGAPSYFRQHVVPRHPNDLAEHNCVTLRLPTHGGLMPWDFGQDGNELSVRVSGQWIFNSMGMTRAAALAGSGLAWLPEDQVQPMLDDGRLQSVLDDWCPHFDGYYAYYPSRRHVTVAMRTVLDALRGPMGS
>NZ_AP021867.1|WP_004147103.1|1071504_1072488_+|aldo/keto-reductase
MQTRELGRSGLKVSALGLGCMGLSHGYGQPVERGQGIALLQAAVERGVTFFDTAEVYGPYTNEDLLGEALAPYRDRLVIATKFGFKDARVDTGLDSRPENIRAVAEASLKRLRTDHIDLFYQHRVDPNVPIEDVAGTVRDLIAEGKVGHFGLSEASAATVRRAHAVQPVAAVQSEYSLWWREPERELLPTLQELGIGFVPFSPLGRGFLTGAINADTTFDANDFRNTVPRFEVEARRANQALVDRISTIAAARGATPAQVALAWLLAQAPWIVPIPGTTKIHRLEENLGAADLQLAPEELQRIAQTLEEISIVGERYNAQRAAQAKG
>NZ_AP021867.1|WP_100434155.1|1079857_1080349_+|transposase
MNRARLRLGRHSRIGQSYILTTVTQERRRYFDDATAAQEVMDVFRRIDAEGLTHSLAYVVMPDHIHWLVEVRAFSLDYVMQRFKSSSALRINRMLGRTGPFWQSSYHDHAIRSEESLFRHAMYIVANPVRANLASCVGEYPYAWCRWEIDGRYQAMDYPEAER
>NZ_AP021867.1|WP_100434156.1|1080469_1081267_-|prolyl-oligopeptidase-family-serine-peptidase
MVRSLSRWLPLLAVLMMTACTSLPDSARGRFEARAVKVDGETAYYQVFIPAGLQAAAPTHLPVILFLHGSGERGSDGVRQTHAGLGPYLREHPGFPALVVFPQVPGHEEWSGHNNRVALAALDAAIAEFGADPARQYLTGMSMGGYGSWNIALDDPRRFAAIVPVCGAVLAPRAKRPTLFVEQVAQESDPYAEIAKRLQHTPIWIFHGALDDVVPPDDDRRLHAAFQSANARDVRYTEYPEGNHNAWDATYADPAMWAWLFAQKR
>NZ_AP021867.1|WP_065722565.1|1081337_1081604_-|hypothetical-protein
MATTIENYFQPGWRDQQYTCTACEWKGSSRAMVMELDEDATEYDCPVCENPLLVVLHPDMAQVQAAAAEGNAEAQEQLDIIASFPHPE
>NZ_AP021867.1|WP_004147235.1|1081665_1083027_-|magnesium-transporter
MAEAVRHDKTARQLRMLSDALDSGRLGPVRRLVNTLAPAEIGNLLESLPPGKREIVWGLVDPEDDGEVLVHVGDDVRESLLADMDPDEIIAAVEDLDIDDLADLVEDLPDTVIDEVLKSMDRENRERLEQVLSYPEDSAGRLMNPDVVTVRADVNVDVVLRYLRLRGELPDHTDHLFVVSRRHQYLGRVSLASLVTHEDTTPINRLIDDEQPAIDVGESDQEVARQFSDHDWISAPVVDDNNILIGRITIDDVVDIIRGQAEHQALGAAGLDEDEDLFSPVWRAMRRRLMWLSVNLCTAFLASSVVGHFEGTIDKLVALAVLMPIVAGLGGNAGTQVLALMVRGLALGQVGSSNARTLLWKEVRVALLNGVVLGSLLGLIVLAWFHSPGLSAVIAIALTCNLLFAALAGVLVPLTLKRFGFDPALASGIFLTAVTDSMGFFTFLGLATLVLLH
>NZ_AP021867.1|WP_012510280.1|1083207_1084977_-|phosphoenolpyruvate--protein-phosphotransferase
MPRARAGQVSSGQRPVQLLAGHGAARGTAMGRARVRLPHALEVAEQRVAVHQVEAELARLHRAVDAARTEMHELRQRLQGALNQEVGEFLDLHALLLDDPELLFGLDELIRSGPYSAGYALRLQRDRLAKVFDGMDDAYLKSRMDDLDHVIGRIHAFLQPERPPAVKGLAGEILVCDNIAPSELAQLQAQGVVGIVTAAGSALSHSAILARSLHLPLIVNVPQLLSRIADGDVLIIDGADGSITSNPQADNLRDYRARLKEHAREQRELGRLRSKPSRTRDQVDIALLANAESLEDVTQAHALGAHGLGLYRTEFLFLQRNELPDEEEQFQTYRDAALGMSGRPVTIRTLDLGADKADRTGLTLSNEENPALGLRGVRLSLARPKVADTQLRAILRASAYGKLRVLVPMVSTREELLAVRRRMLKLTEQLRGEGHMVSDHVPLGAMIEVPAAALALESFIDLVDFLSIGTNDLVQYLLAADRNNEALGELYSPLHPAVLRLLQMVIETGVRHRIPVAVCGEIAGDARMTPLLLALGLTEFSLHPGTLLEVRRAIRDADLGALRARAPKLLAARDRRAIERWLALVADAS
>NZ_AP021867.1|WP_046983647.1|1084979_1085249_-|HPr-family-phosphocarrier-protein
MLERELTVSNRLGLHARATAKLVQTLAPFRCNVTMAAKGREINAKSIMGVMLLAAGQGTPVTVRINGEDEAAAMEAVVGLFERRFDEDN
>NZ_AP021867.1|WP_100434157.1|1085241_1085634_-|PTS-fructose-IIA-subunit-family-protein
MTCGILLVTHPGVGTALLDVATRLLRQLPLKTEAFEVPFDADLDVLLPLASAALRRVDGGNGVLILTDLYGASPANLAGQLARLGTPVRRVSALSLPMLLRVMNYPEQGLDQLPATAAAGTRNGAIVDDA
>NZ_AP021867.1|WP_100434158.1|1085937_1086822_-|RNase-adapter-RapZ
MSTATPSAPTLIIVSGLSGSGKSVALKTFEDQDYYCSDNLPINLLPDFVRSLLANHDGSAPRRLAVGIDVRGQSDLSQLGNWRQLATDAGVEVKVLFFEASDEAVLKRYADTRRRHPLSQLGLSLPEAIARERELTAPLRREADAVIDTSALNVHQLRRRIITEFALDHATRLSLLFESFAYKRGVPAEADFVFDARVLPNPHWDPDLRALSGREPGVRDYLEAQPDVQRYLAQLTDFLDTWLPKLGDGTRSYVTVAFGCTGGKHRSVFLAERMARHAREMGWEDVATYHREQD
>NZ_AP021867.1|WP_005408388.1|1086851_1087802_-|HPr-kinase/phosphorylase
MNTSITARELFEQQRERLGLRWAAGKSGEKRELEAGNTVSRRPSLAGYLNAIYPNKVQILGTEELSWLDALEPRQRWETIEKIMQSHPLALVLTRNQACPEDLRAAADESGTPLWLSPKRGHELLNHLSYHLARTLAPRVILHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPELLQDLLEVRGLGVLNVREMFGDTAVKKNKYLRLIVHLTKPMTEPTPHGYERLTGDSGTRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPAAMFIARHSNLLERRTP
>NZ_AP021867.1|WP_100434159.1|1087798_1088251_-|PTS-sugar-transporter-subunit-IIA
MPLTDLLAAVQTQLCTATDRDSVLQAAAGLLACRQANAEQIYLNLCQREALGSTAIGHGIAIPHGRAPTLDRPRGALLRLATPVDFGGDEPVDLVFAMAVPAHYTHQHLMLLSELAELFSAPDIRDALRAAGDARALRQALELTPPASAA

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Crispr_ID: NZ_AP021867_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP021867_4

1382120-1382211

Orphan

Consensus_repeat	Method
TTGCCGGCCAGCGGCTGGCACTACCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP021867_4

>merge|NZ_AP021867|4|1382120-1382211|CRISPRCasFinder
TTGCCGGCCAGCGGCTGGCACTACCGACTCTGCCTGGGTCTGGTAGTTGCCAACCTTGGTTGGCATTGCCGGCCAGCGGCCGGCACTACCGA

>NZ_AP021867|4|4|1382120-1382211|CRISPRCasFinder
TTGCCGGCCAGCGGCTGGCACTACCGA	CTCTGCCTGGGTCTGGTAGTTGCCAACCTTGGTTGGCA
TTGCCGGCCAGCGGCCGGCACTACCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP021867.1\|WP_012510454.1\|1379942_1380611_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_012510457.1\|1381681_1382041_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319937
NZ_AP021867.1\|WP_032969325.1\|1385695_1386412_-\|MtnX-like-HAD-IB-family-phosphatase	unknown	unknown	gnl\|CDD\|319826
NZ_AP021867.1\|WP_153675145.1\|1383136_1384201_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|225688
NZ_AP021867.1\|WP_012510452.1\|1378145_1379039_-\|LysR-family-transcriptional-regulator-ArgP	unknown	unknown	gnl\|CDD\|235144
NZ_AP021867.1\|WP_032127529.1\|1384230_1385631_-\|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|223238
NZ_AP021867.1\|WP_004149835.1\|1375660_1376674_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|224482
NZ_AP021867.1\|WP_012510466.1\|1389472_1390852_-\|sensor-histidine-kinase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|182388
NZ_AP021867.1\|WP_153675143.1\|1376666_1378067_-\|TolC-family-protein	unknown	unknown	gnl\|CDD\|224455
NZ_AP021867.1\|WP_153675149.1\|1387799_1388198_-\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|307170
NZ_AP021867.1\|WP_174238319.1\|1380607_1381390_-\|type-I-methionyl-aminopeptidase	unknown	unknown	gnl\|CDD\|238519
NZ_AP021867.1\|WP_012510456.1\|1381400_1381613_-\|ParD-like-family-protein	unknown	unknown	gnl\|CDD\|314732
NZ_AP021867.1\|WP_012510464.1\|1388194_1388554_-\|EamA-family-transporter	unknown	unknown	unknown
NZ_AP021867.1\|WP_153675151.1\|1388555_1389392_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|224561
NZ_AP021867.1\|WP_004150098.1\|1390848_1391532_-\|response-regulator	unknown	unknown	gnl\|CDD\|182612
NZ_AP021867.1\|WP_153675141.1\|1374488_1375676_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|378925
NZ_AP021867.1\|WP_012510453.1\|1379146_1379767_+\|amino-acid-transporter	unknown	unknown	gnl\|CDD\|224198
NZ_AP021867.1\|WP_153675147.1\|1386586_1387789_-\|DegT/DnrJ/EryC1/StrS-family-aminotransferase	unknown	unknown	gnl\|CDD\|99740
NZ_AP021867.1\|WP_012510449.1\|1373364_1374492_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|378925
NZ_AP021867.1\|WP_012510458.1\|1382248_1383133_-\|arginase-family-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP021867.1\|WP_004149835.1\|1375660_1376674_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|224482	COG1566, EmrA, Multidrug resistance efflux pump [Defense mechanisms].	4.67037e-36
NZ_AP021867.1\|WP_012510457.1\|1381681_1382041_-\|VOC-family-protein	gnl\|CDD\|319937	cd08349, BLMA_like, Bleomycin binding protein (BLMA) and similar proteins. BLMA also called Bleomycin resistance protein, confers Bm resistance by directly binding to Bm. Bm is a glycopeptide antibiotic produced naturally by actinomycetes. It is a potent anti-cancer drug, which acts as a strong DNA-cutting agent, thereby causing cell death. BLMA is produced by actinomycetes to protect themselves against their own lethal compound. BLMA has two identically-folded subdomains, with the same alpha/beta fold; these two halves have no sequence similarity. BLMAs are dimers and each dimer binds to two Bm molecules at the Bm-binding pockets formed at the dimer interface; two Bm molecules are bound per dimer. BLMA belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. As for the larger superfamily, this family contains members with or without domain swapping.	8.86623e-38
NZ_AP021867.1\|WP_032969325.1\|1385695_1386412_-\|MtnX-like-HAD-IB-family-phosphatase	gnl\|CDD\|319826	cd07524, HAD_Pase, phosphatase, similar to Bacillus subtilis MtnX; belongs to the haloacid dehalogenase-like superfamily. Bacillus subtilis recycles two toxic byproducts of polyamine metabolism, methylthioadenosine and methylthioribose, into methionine by a salvage pathway. The sixth reaction in this pathway is catalyzed by B. subtilis MtnX: the dephosphorylation of 2- hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HKMTP- 1-P) into 1,2-dihydroxy-3-keto-5-methylthiopentene. The hydrolysis of HK-MTP-1-P is a two-step mechanism involving the formation of a transiently phosphorylated aspartyl intermediate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	5.28384e-35
NZ_AP021867.1\|WP_153675145.1\|1383136_1384201_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|225688	COG3146, COG3146, Uncharacterized protein conserved in bacteria [Function unknown].	3.23191e-07
NZ_AP021867.1\|WP_012510452.1\|1378145_1379039_-\|LysR-family-transcriptional-regulator-ArgP	gnl\|CDD\|235144	PRK03635, PRK03635, ArgP/LysG family DNA-binding transcriptional regulator.	1.55255e-147
NZ_AP021867.1\|WP_032127529.1\|1384230_1385631_-\|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|223238	COG0160, GabT, 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism].	2.67476e-110
NZ_AP021867.1\|WP_153675143.1\|1376666_1378067_-\|TolC-family-protein	gnl\|CDD\|224455	COG1538, TolC, Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion].	1.36696e-37
NZ_AP021867.1\|WP_012510466.1\|1389472_1390852_-\|sensor-histidine-kinase-N-terminal-domain-containing-protein	gnl\|CDD\|182388	PRK10337, PRK10337, sensor protein QseC; Provisional.	1.00636e-51
NZ_AP021867.1\|WP_153675149.1\|1387799_1388198_-\|EamA-family-transporter	gnl\|CDD\|307170	pfam00892, EamA, EamA-like transporter family. This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.	6.72709e-06
NZ_AP021867.1\|WP_174238319.1\|1380607_1381390_-\|type-I-methionyl-aminopeptidase	gnl\|CDD\|238519	cd01086, MetAP1, Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.	4.51011e-129
NZ_AP021867.1\|WP_012510456.1\|1381400_1381613_-\|ParD-like-family-protein	gnl\|CDD\|314732	pfam11903, ParD_like, ParD-like antitoxin of type II bacterial toxin-antitoxin system. ParD-like antitoxin is a family of archaeal and bacterial proteins of a type II bacterial toxin-antitoxin system. Many of the cognate toxins for these molecules fall into family ParE-like_toxin, pfam15781. Gene-pairs are expressed from the same operon, the toxin of the pair being expressed first, eg, for UniProtKB:Q3AQ93 and UniProtKB:Q3AQ94.	8.38618e-28
NZ_AP021867.1\|WP_153675151.1\|1388555_1389392_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|224561	COG1647, COG1647, Esterase/lipase [General function prediction only].	5.66712e-47
NZ_AP021867.1\|WP_004150098.1\|1390848_1391532_-\|response-regulator	gnl\|CDD\|182612	PRK10643, PRK10643, two-component system response regulator PmrA.	1.79536e-68
NZ_AP021867.1\|WP_153675141.1\|1374488_1375676_-\|ABC-transporter-permease	gnl\|CDD\|378925	pfam12698, ABC2_membrane_3, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	6.22809e-32
NZ_AP021867.1\|WP_012510453.1\|1379146_1379767_+\|amino-acid-transporter	gnl\|CDD\|224198	COG1279, COG1279, Lysine efflux permease [General function prediction only].	1.21195e-62
NZ_AP021867.1\|WP_153675147.1\|1386586_1387789_-\|DegT/DnrJ/EryC1/StrS-family-aminotransferase	gnl\|CDD\|99740	cd00616, AHBA_syn, 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.	2.52316e-44
NZ_AP021867.1\|WP_012510449.1\|1373364_1374492_-\|ABC-transporter-permease	gnl\|CDD\|378925	pfam12698, ABC2_membrane_3, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	2.24228e-31

>NZ_AP021867.1|WP_012510457.1|1381681_1382041_-|VOC-family-protein
MSQTVIPQLRMRHADTTLPFYVQGLGFVVDWEHRFEPGFPLFAQLTRDGQTIFLTEHSGDCEVGGAVYFIVEDVDALHRAFSAAGVPIEQPPHDTEWGSREMLLRDPDGNRLRFATDAS
>NZ_AP021867.1|WP_012510456.1|1381400_1381613_-|ParD-like-family-protein
MGIVNIDDTLHDQLRRACTVSSRSINAQANFWIRVGMLCELNPTLSFQDIVASELRAAGVQPPLLPPGQA
>NZ_AP021867.1|WP_174238319.1|1380607_1381390_-|type-I-methionyl-aminopeptidase
MIKRPDEIALMAESGRLLAQVFAALDRLPLQGRSTMEINDFVERMIVDELQARPASKGQYGFPYVLNTSIDNVICHGVPSTTDVLRNGQIVNLDITLEKNGYIADSSTTYLVGEVDYAARRLVQTAYQAMWKGIAAVRPDARLGDIGHAIARHARSHGYSVVKEYCGHGIGQEMHEEPQILHYGHPNTGMVLEEGMVFTIEPMLNQGKPAIRQQPDEWPVYTRDGKLSAQFEHTVAVTRTGVRVLTLRPGETPLCAVDGA
>NZ_AP021867.1|WP_012510454.1|1379942_1380611_+|hypothetical-protein
MKDNLQLLLSHLGRTFLFGLMMALPPALAWLDIHWLGNAVGEWSLVELTQEGFLVASVAAFVRLALRRADDRAFAVLAAALFACMLLREMDEALDLIAHGFWKYPVAVLIIGSLAWASRDWRRAMQALVRFLVSRPGTVMTIGLVLLLFYSRLIGMTSLWTGLLGDQYIRVFKNTIEETTELLGYTFILAASVGYVAQRVREPLTARKRALHEGTGMQQRPL
>NZ_AP021867.1|WP_012510453.1|1379146_1379767_+|amino-acid-transporter
MWIAATAAGLFAGAGLIIAIGAQNAFVLRQGLQQHRVGTVVLACAGADIALILAGVGGMGALVLQWPLLLQVLRFGGAAFLLWYGLQAGLRAWRGGSALAAAEAQGGSGRQVLLTCLAFTLLNPHVYLDTVVLLGSLSTRYPGDLRWAFAAGACAASVAWFCTLGYGARLLQPVFRRPAAWRVLDAGVAAFMFCLATLLLLRPLSP
>NZ_AP021867.1|WP_012510452.1|1378145_1379039_-|LysR-family-transcriptional-regulator-ArgP
MDLIHPQLAAFAAVLEEGSFEAAARRLSISPSALSQRIKALEDRLGQVLVVRQAPCRPTAAGEALLRRVRPMQALEAEALAELLPERGSDAARTPIPLAVNDDSLDTWLVPAIAELHQRHGYLFDLRMDDQDHTLQLLRDGSVLGAVTAESQPVKGCNVHPLGAMRYHAIASPGFARQYFSDGMQAAALARAPMLVFNRKDELQWRFVRRLTRARLQPPLHYLPSSTGFVEAAACGLGWGMAPESLVAPAVRAGRVVVLEPRRWLDVPLYWQHAAVRSSTLQHITQALRTAASSTLR
>NZ_AP021867.1|WP_153675143.1|1376666_1378067_-|TolC-family-protein
MGVIGRRTRMHGAKAALALAACLPLAAAAQTLTDAPALDWEQARQRLEQVSDALAAADAAVRNKQDLQDATRLLRLPEITGEVRRLQFQKTLTLPLGSLAPVAEAYGIDSPLSFTERDWRTRPVVTAVLPLYTGGVIPAAQRAASAAHEQASAEREAQRQSLTVQLAQAYFGQRLAEQAVDVRRDVRDGLNRHLSDAEKLEREGFATRAQRLQATVARDKAEREYQKTVNDLATLKAALATLLRSGGEVQPVSPLFVQRVPLEPVASFERTAQARQPQIARLRAMVAQAEQGVRVQQAKLKPQIFAFGQYDFRRRDEMLTDPDWAFGIGLKYTFLSPNSRPAQISAARAQQDQAEAGLREAENQVALGVRKAWNELETARQQYVLLDSSIAQAKENLRLQELAFREGQATSLDVIDARLGLGGARVERAQAAYQYDIALAQLLEVSGQMDRFEEFRRRADEVIDHE
>NZ_AP021867.1|WP_004149835.1|1375660_1376674_-|efflux-RND-transporter-periplasmic-adaptor-subunit
MSDVLHDDATTPPAKRRLGPILIVVLLVVVVLGLWLAWRSPADQIQGMADADTINVAAKITARVAELKVREGDRVQPGQVLFLLDSPEVAAKEQQAHGALAAAQAVADKADEGARSEDIRAAEANWKRAEAGATLAEATYQRVQNLFNEGVMTRQKRDEAHAQATSSRELARAARAQYDMALAGAREQDKRAAQGQVQQAQGAVAEVNAARVEVEGRAPVAGEINKRMADPGELVPAGYPVFTLVDIDRMWVAMNLRESQMQGLKVGSKLRGSVPALGQDGEFEVYFINPAGDYATWRTTRQSSGYDVRSFEVRVRPVRRIEGFRPGMSVLFAWPQH
>NZ_AP021867.1|WP_153675141.1|1374488_1375676_-|ABC-transporter-permease
MAPALSPGRGGFAASWRRELRSLRGNRADLLLVTLLPLLMLAVMAWMFTPSVMRDIPIAVVDLDHSSDSRLLLRMLDASPGVRIASQPADMQDARSQLRRLDVFAIVLVPRDVTRQALRGRQGTVFAYYNATYMTTGQSAARDIGDAVSAWNSRLLRERIGLQVGPGKLRAAPIAVQSDILYNPARSYELFLLPLIFPAVLSLVLALAVAGSLGREIRDSTLPAWLGRTPWPAIAGKVAPYILLFSVYGALGIGYLAWLRGDGVAGSVLMLLLAQPLFYLATAAYALFFVGVTRDMGTALSAVGLSIGTALAFSSATFPVLDGPLFTRIWHQLLPLSAYIKLQTQQQFIGSPLQVSVWPLATLLLMSVVAGGIGGLRLIAFARTPEAAQPAGADA
>NZ_AP021867.1|WP_012510449.1|1373364_1374492_-|ABC-transporter-permease
MSALWRSLRQTLMAVLCDRYAIVVMVGAVILYSFFYPAAYRHQVAGNLPVLVVDEDHSATSRELLRKLDALRVARVVGQPADIDSARQQLEAGHAEGIVLIPANLERDILRGHPAKLVLLGNGAYLGRASWVLGSVADALGAFGREAVVGQAAFMGAPQAPPVTLVQRPLYNTQEGYGSAIVPGVAELIVQQTLLMGIGVLLGGRRLALGRRLRFDLPTLAGMALGFGLIGLFGLFYYAGFTAWVQDYPRGGNPLGQLLGGTLFIAATVAFGLFVGSFFRTRERAFQYIIATSIPLFFLANLSWPAVMTPQPLVWLAQLLPTTSGINLMVRLNQMDASLAEVSHELITLSALLLLYGALAAWRLLAKKGTEGIKS
>NZ_AP021867.1|WP_012510458.1|1382248_1383133_-|arginase-family-protein
MPLRSPLILDLDSGVLPLPQAQTLALPQWHDPLRFACSNATLERFAAEVLAPLPAQLGTVMLGSGDFHHLSLPLLQRMRTQAPFQLVVLDNHPDNMRFPFGMHCGSWVNAASKLPQISHIHVLGITSSDIGLGHAWENHWRPLMSGRLTYWCMDVDVGWGHRLGMGHAFRRFEHPEALVAAFAAEQAKSPQPTYLSIDKDVFTEDVARSNWDQGRFQLEHALVVIEALRAGGLAGSDITGEVSLANYQSRFKRWLSSLDGQPDVSAEDLPVWQTRHQQVNQELLAAIAAVPTAC
>NZ_AP021867.1|WP_153675145.1|1383136_1384201_-|GNAT-family-N-acetyltransferase
MEMTSRASSTALEPAALLEGFLAHPPLGFEAGRLPSGLPTFRAPLDLTTTMDDGLRGKLLGLPLSRLWRPWITWQTRFIGATSTEYTPLPAHVAPEALAEDVTRHAIGDTRLLVVKDLAIDSPLLDDAANAHSDAFLQALLARGFVELEGMPLAWVAIDFDSIDGYLGRLSSSRRKNIRRKLRSRDDLQIDCIATGDPALADPQLQAELYALYLGVYAQSAVHFDQLDLSYFQHLLADSLGQGRLFLYRHQGQLIGWNLCYVHAGKLVDKYIGLAYPQSREHNLYAVSWMHNLEYALQHGLSHYVAGWTDSRIKAELGASFTSTRHAIHARSPLLRAALRRLAPYLQGEPDGGG
>NZ_AP021867.1|WP_032127529.1|1384230_1385631_-|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme
MNIFDKNADAAASDAQLLADEARYSSFGDTVHYVDPPKIFQRGEGSYMFDGAGVPYLDLQMWYSACNFGYSNKRLNDALKDQIDTLPQVASQYLHPTRVQLAKTIAVDMHEKFGLDGRVHFNVGGAQAIEDSLKIVRNARGGKSLMFAFEGGYHGRTLGASSITSSYRYRRRYGHFGERAMFIPFPYPFRRPKGMTPEEYSDHCVWQFERLFESEYNGVWDPKVGQAEYAAFYVEPIQGTGGYVIPPRNFFTGLKRVLDKYGILMVVDEIQMGFWRTGKLWAIEHFGVTPDVLVFGKALTNGLNPLSGLWAREELINPTVFPPGSTHSTFNSNPLGTRLGLEVLKLGKEMDYERTVPEKGAYFLDGLRGLQKRHPEIGDVDGLGLALRAEICQTDGYTPNKELLDRMVDIGLAGDLLHDGKRMGLVLDVGGWYKNVITFAPSLDISYEEIDLAITLLDQALTKAKG
>NZ_AP021867.1|WP_032969325.1|1385695_1386412_-|MtnX-like-HAD-IB-family-phosphatase
MRWSILCDFDGTISLEDVIDSLLEKYGQPGWQELEDQWKAGKIGSRECMQGQVRLLNLDPATLDAHLDQVQIDPGFAAFVSRAEQLGVPLRIVSDGLDYAIHRILANHGLSRLPVVANHLRWCDDHWELESPYQAEGCRSGTCKCTCAAQARANEAPRVLMIGDGSSDFCVSEDADFVFAKRRLITHCTHAGIEHAAIDTFHDAIALLPRLLDGSLVQPRRIDASPQPAVLPLLLATA
>NZ_AP021867.1|WP_153675147.1|1386586_1387789_-|DegT/DnrJ/EryC1/StrS-family-aminotransferase
MSLFARELPPTAGLPMQASDFLPGGGDLREILASQLGTPPLQLTCSGTHALLIALRTLRRRAPKRDTVIMPAYTCPLVPIAVHSLGLRVQLCDTRRGHFDFDPGQLKRLADARTLAILPTHLGGRIADVDLANEVARAAGAWVIEDAAQALGARVGNSSVGLRGDIGFFSLAAGKGLSLHEGGLLVSRDDALRAALAEHAAEQTRFNLRWELLRSVQLLGLAACYRPSLLSLVYGNPLRRALQRGDLEEAVGDIFALDIPQHRVSRWRQNIGSNAARRLPAFLQAGRLRALQLRVQLAQLPAVEVVDGLAGTGGTWPMLMLLLPSQQARDGVLKDLWPRGLGVSRMFIHALPDYTYLRDIVPQDDMPNARDFAARMLTLGNSAWQTREDTAEILQALARA
>NZ_AP021867.1|WP_153675149.1|1387799_1388198_-|EamA-family-transporter
MRRLYVIGFPLLMAFDTLAQLCFKYAGDAALPVEANTAWLLRVLSQPWVYGAILGYVGAFFTWMSLLRHAPIGPAFAASHLEVISVLLLSAWLLNEPLTLHHLLGAVLTVAGIVCLGRAEADDPHSPAETTT
>NZ_AP021867.1|WP_012510464.1|1388194_1388554_-|EamA-family-transporter
MGSLATLLWLVNVVLDTGGQLAFKAAASDPNEAEGLQRWKHMLSRPWLWLGIACYVLEFVAWIAFLSLVPLSKGVLLGSINIVALMIAGRILFREKLTPLRVTGMLLVTAGVAVVGAGS
>NZ_AP021867.1|WP_153675151.1|1388555_1389392_-|alpha/beta-fold-hydrolase
MTETHDFFLPGGPQGVLLVHGLTGTPAEMRMLGKGLNNAGFTVHGVQLPGHCGSVDDLLATTWEQWYQGVEDAAAALRGKVDQLFVGGLSMGAVLSLALAARRPEWVSGVGVYGATFRYDGWNIPAVARFSFLLPWFKRFNIGRDRMFMEEPPYGLRDERLRAQVSAAMLSGDSAAAGLPGNPWHALAEMRALSNWTRRHLHQVTAPCLVMHAREDDVASMGNAELVMSRISGPKELVVLEDSYHMITIDRERRDVIRRSARFFSEIGERSGILKAVA
>NZ_AP021867.1|WP_012510466.1|1389472_1390852_-|sensor-histidine-kinase-N-terminal-domain-containing-protein
MISGPPSLRRRLLAFLALPMLGLLIFNTVLAYYVALDYSNRIHDRNLIDDTHSFAQMLSTMPVTSDLSPQARFLIEYDPDGHRYFNVDSSRKGTLSGNADFSPYAPSQDCTGVHPALYDGTLNGQQVRMATVCTQAMNDPQDQLAVTVAESMADRRQRAREILMIIIPLMTMLALGTAALVWFGVTYGLRILTPLTTRLAQRRGELAPISDADVPEEIQPLISTIDGLFARQAEMITLQNRFIADAAHQLRSPLAGMALHVDQALAHGDPDTVREALQHIRRLNQRTARVSTQLLALSRAQTVPETVEALDLGTLLPQWVGTRVPEAIRDGIDLGYRGSSQPLRVLGNGALLQEALDNLIDNALRYAGRGATVTVGVQALDDNDVELYVEDNGPGVPEDVMPRLGERFFRAPGTTASGTGLGLAIAHEAVEHFGGRLGFLNRAGGGLKVTITLPLLKAP
>NZ_AP021867.1|WP_004150098.1|1390848_1391532_-|response-regulator
MRVLIAEDDPDIASGLCASLRRQGHVVDHVDNGAHADAALGSTQYALLVLDLGLPQLDGRDVLQRLRQRGDGLAVLVVTARDGLAERVRVLDLGADDYLVKPFALDEFEARVRAQLRRVTSNGNPDLRIGRLRLDLAGHRVWIDEQSLELTAREFGLLSALAVRAERIVSRAQLVEALCDWGQDLTDNGLDIALHRLRRKLQPGGIGIRTVRGLGYMLEDAQDDSTP

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Crispr_ID: NZ_AP021867_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP021867_5

1398711-1398783

Orphan

Consensus_repeat	Method
CCGGGTAGCGCCGGGCCATGCCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP021867_5

>merge|NZ_AP021867|5|1398711-1398783|CRISPRCasFinder
CCGGGTAGCGCCGGGCCATGCCCGATGGCATCGTCCAGCGATCCGAACCCCCGGTAGCGCCGGGCCATGCCCG

>NZ_AP021867|5|5|1398711-1398783|CRISPRCasFinder
CCGGGTAGCGCCGGGCCATGCCCG	ATGGCATCGTCCAGCGATCCGAACC
CCCGGTAGCGCCGGGCCATGCCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP021867.1\|WP_012510471.1\|1398879_1399860_+\|cation-transporter	unknown	unknown	gnl\|CDD\|224151
NZ_AP021867.1\|WP_100468075.1\|1401672_1403766_+\|M13-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341056
NZ_AP021867.1\|WP_100468076.1\|1403858_1404476_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|225116
NZ_AP021867.1\|WP_153675160.1\|1396410_1398660_+\|FepA-family-TonB-dependent-siderophore-receptor	unknown	unknown	gnl\|CDD\|237410
NZ_AP021867.1\|WP_153675156.1\|1393392_1394610_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340882
NZ_AP021867.1\|WP_004150342.1\|1408777_1409635_-\|23S-rRNA-(adenine(2030)-N(6))-methyltransferase-RlmJ	unknown	unknown	gnl\|CDD\|225509
NZ_AP021867.1\|WP_153675149.1\|1387799_1388198_-\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|307170
NZ_AP021867.1\|WP_012510476.1\|1409670_1410399_+\|two-component-system-response-regulator-CreB	unknown	unknown	gnl\|CDD\|236838
NZ_AP021867.1\|WP_004150217.1\|1400762_1401512_+\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|184516
NZ_AP021867.1\|WP_012510464.1\|1388194_1388554_-\|EamA-family-transporter	unknown	unknown	unknown
NZ_AP021867.1\|WP_153675151.1\|1388555_1389392_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|224561
NZ_AP021867.1\|WP_153675153.1\|1391664_1392792_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277368
NZ_AP021867.1\|WP_004150098.1\|1390848_1391532_-\|response-regulator	unknown	unknown	gnl\|CDD\|182612
NZ_AP021867.1\|WP_153675155.1\|1392865_1393315_-\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_AP021867.1\|WP_012510472.1\|1399984_1400668_-\|deoxyribonuclease-V	unknown	unknown	gnl\|CDD\|236937
NZ_AP021867.1\|WP_012510466.1\|1389472_1390852_-\|sensor-histidine-kinase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|182388
NZ_AP021867.1\|WP_004150402.1\|1410402_1411863_+\|two-component-system-sensor-histidine-kinase-CreC	unknown	unknown	gnl\|CDD\|236846
NZ_AP021867.1\|WP_153675158.1\|1394705_1396121_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_AP021867.1\|WP_100434309.1\|1404522_1407987_-\|transcription-repair-coupling-factor	unknown	unknown	gnl\|CDD\|224118
NZ_AP021867.1\|WP_004150340.1\|1408136_1408682_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181

Protein	Function_ID	Function_description	E-value
NZ_AP021867.1\|WP_012510471.1\|1398879_1399860_+\|cation-transporter	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	4.93198e-115
NZ_AP021867.1\|WP_100468075.1\|1401672_1403766_+\|M13-family-metallopeptidase	gnl\|CDD\|341056	cd08662, M13, Peptidase family M13 includes neprilysin and endothelin-converting enzyme I. The M13 family of metallopeptidases includes neprilysin (neutral endopeptidase, NEP, enkephalinase, CD10, CALLA, EC 3.4.24.11), endothelin-converting enzyme I (ECE-1, EC 3.4.24.71), erythrocyte surface antigen KELL (ECE-3), phosphate-regulating gene on the X chromosome (PHEX), soluble secreted endopeptidase (SEP), and damage-induced neuronal endopeptidase (DINE)/X-converting enzyme (XCE). Proteins in this family fulfill a broad range of physiological roles due to the greater variation in the active site's S2' subsite allowing substrate specificity. NEP is expressed in a variety of tissues including kidney and brain, and is involved in many physiological and pathological processes, including blood pressure and inflammatory response. It degrades a wide array of substrates such as substance P, enkephalins, cholecystokinin, neurotensin and somatostatin. It is an important enzyme in the regulation of amyloid-beta (Abeta) protein that forms amyloid plaques that are associated with Alzeimers disease (AD). ECE-1 catalyzes the final rate-limiting step in the biosynthesis of endothelins via post-translational conversion of the biologically inactive big endothelins. Like NEP, it also hydrolyzes bradykinin, substance P, neurotensin, and Abeta. Endothelin-1 overproduction has been implicated in various diseases including stroke, asthma, hypertension, and cardiac and renal failure. Kell is a homolog of NEP and constitutes a major antigen on human erythrocytes; it preferentially cleaves big endothelin-3 to produce bioactive endothelin-3, but is also known to cleave substance P and neurokinin A. PHEX forms a complex interaction with fibroblast growth factor 23 (FGF23) and matrix extracellular phosphoglycoprotein, causing bone mineralization. A loss-of-function mutation in PHEX disrupts this interaction leading to hypophosphatemic rickets; X-linked hypophosphatemic (XLH) rickets is the most common form of metabolic rickets. ECEL1 is a brain metalloprotease which plays a critical role in the nervous regulation of the respiratory system, while DINE is abundantly expressed in the hypothalamus and its expression responds to nerve injury. A majority of these M13 proteases are prime therapeutic targets for selective inhibition.	0
NZ_AP021867.1\|WP_100468076.1\|1403858_1404476_-\|HD-domain-containing-protein	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	2.36591e-56
NZ_AP021867.1\|WP_153675160.1\|1396410_1398660_+\|FepA-family-TonB-dependent-siderophore-receptor	gnl\|CDD\|237410	PRK13524, PRK13524, FepA family TonB-dependent siderophore receptor.	0
NZ_AP021867.1\|WP_153675156.1\|1393392_1394610_+\|MFS-transporter	gnl\|CDD\|340882	cd17324, MFS_NepI_like, Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily. This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.79917e-48
NZ_AP021867.1\|WP_004150342.1\|1408777_1409635_-\|23S-rRNA-(adenine(2030)-N(6))-methyltransferase-RlmJ	gnl\|CDD\|225509	COG2961, ComJ, Protein involved in catabolism of external DNA [General function prediction only].	8.89197e-128
NZ_AP021867.1\|WP_153675149.1\|1387799_1388198_-\|EamA-family-transporter	gnl\|CDD\|307170	pfam00892, EamA, EamA-like transporter family. This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.	6.72709e-06
NZ_AP021867.1\|WP_012510476.1\|1409670_1410399_+\|two-component-system-response-regulator-CreB	gnl\|CDD\|236838	PRK11083, PRK11083, DNA-binding response regulator CreB; Provisional.	4.17329e-127
NZ_AP021867.1\|WP_004150217.1\|1400762_1401512_+\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	gnl\|CDD\|184516	PRK14115, gpmA, 2,3-diphosphoglycerate-dependent phosphoglycerate mutase.	4.96452e-176
NZ_AP021867.1\|WP_153675151.1\|1388555_1389392_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|224561	COG1647, COG1647, Esterase/lipase [General function prediction only].	5.66712e-47
NZ_AP021867.1\|WP_153675153.1\|1391664_1392792_-\|metallophosphoesterase	gnl\|CDD\|277368	cd07425, MPP_Shelphs, Shewanella-like phosphatases, metallophosphatase domain. This family includes bacterial, eukaryotic, and archeal proteins orthologous to the Shewanella cold-active protein-tyrosine phosphatase, CAPTPase. CAPTPase is an uncharacterized protein that belongs to the Shelph (Shewanella-like phosphatase) family of PPP (phosphoprotein phosphatases). The PPP family is one of two known protein phosphatase families specific for serine and threonine. In addition to Shelps, the PPP family also includes: PP1, PP2A, PP2B (calcineurin), PP4, PP5, PP6, PP7, Bsu1, RdgC, PrpE, PrpA/PrpB, and ApA4 hydrolase. The PPP catalytic domain is defined by three conserved motifs (-GDXHG-, -GDXVDRG- and -GNHE-). The PPP enzyme family is ancient with members found in all eukaryotes, and in most bacterial and archeal genomes. Dephosphorylation of phosphoserines and phosphothreonines on target proteins plays a central role in the regulation of many cellular processes. PPPs belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	8.05501e-55
NZ_AP021867.1\|WP_004150098.1\|1390848_1391532_-\|response-regulator	gnl\|CDD\|182612	PRK10643, PRK10643, two-component system response regulator PmrA.	1.79536e-68
NZ_AP021867.1\|WP_153675155.1\|1392865_1393315_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	6.56528e-31
NZ_AP021867.1\|WP_012510472.1\|1399984_1400668_-\|deoxyribonuclease-V	gnl\|CDD\|236937	PRK11617, PRK11617, deoxyribonuclease V.	5.14423e-124
NZ_AP021867.1\|WP_012510466.1\|1389472_1390852_-\|sensor-histidine-kinase-N-terminal-domain-containing-protein	gnl\|CDD\|182388	PRK10337, PRK10337, sensor protein QseC; Provisional.	1.00636e-51
NZ_AP021867.1\|WP_004150402.1\|1410402_1411863_+\|two-component-system-sensor-histidine-kinase-CreC	gnl\|CDD\|236846	PRK11100, PRK11100, sensory histidine kinase CreC; Provisional.	0
NZ_AP021867.1\|WP_153675158.1\|1394705_1396121_-\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	9.16143e-61
NZ_AP021867.1\|WP_100434309.1\|1404522_1407987_-\|transcription-repair-coupling-factor	gnl\|CDD\|224118	COG1197, Mfd, Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription].	0
NZ_AP021867.1\|WP_004150340.1\|1408136_1408682_-\|N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.47008e-07

>NZ_AP021867.1|WP_153675160.1|1396410_1398660_+|FepA-family-TonB-dependent-siderophore-receptor
MSRAVVLSPRPLALAVAALLAGSALTAHAEADATDIDTVHVTASQIARQALGTSTITAEDIARRPPANDIAELLRTMPGVNLTGNSASGQYGNNRQIDLRGMGPENTLILVDGKRIGARDAVRMGRSGERNTRGDTNWVPAEMIERIEVLRGPAAARYGSGASGGVVNIITKRPTGDLTGAVDLYGLVPEHSAEGGSERVGLQLSGPMTDTLSFRLYGNLNKTDADSLDLNRQYATNPNAVPPAGREGVKNRDVNALLRWDVTANQVVEFEAGTSRQGNIYAGDRAVSTTGTSTPIDLGALAEQQAETNRMYRTTGAITHRGRWGDVTSRVTAAVEGVNNSRINEGLAGGPEGSFNGTDWSTSRLRNYQLDGEVSFPTTLGGAENIWTLGFEYLDSRLTDPYSMSQSSSSGGGFPGLSADRARGKADAQTTAVFVEDNIYLGERWIVTPGLRFDHHSQFGNNTSPSLNAQFRINSDWVVKGGIARAFKAPNLYQSNPDYLYYTRGNGCPNALPSLGAGCYMRGNADLKAETSLNKELGVEWAPQSGWQASLTYFHNDYKDKIQAGYNQIGLTADTKGRIFRWENAPKAIVQGLEGNLVIPLLGEQGNRLKWSNNFTYMVENENKSTGQPLSVIPKYTINTMLDWQATDKLSLLLTGTFYGKQKPATTNINNDPRCTGTCDPSIALQDRGAYNIWGVSARYKVTETVSFGFGVNNLADKRLFREANSSDAGAATYNEPGRAYWASLRFGF
>NZ_AP021867.1|WP_153675158.1|1394705_1396121_-|diguanylate-cyclase
MEPPQLDDASQPLAEAWQQCLLQAGPAATALLHAAAADAPPALAQRFYEVLLQDTRARRFLSHDQVKQRLQPAMQRWLAQLLTTDASGIANTVASQRIIGDVHARVGIPVDLVTRGARVLKHELFVRLRDDAPDSDTAFAAIDCLSAIMDIAMEGMTLAYTHARERSTRADAAYRLFSLVQNVSTERERQRALLLDWENALLYALAGHVQGSDGASLATSEFGLWFTHKGIPSFGESSETQQVDQLMARIDRCLQRAAADDPAQRLAVLPAIREDLAAIRTLMTLLFERIGELDAGSDALTNLLNRRFLPTVLRREIELATRNRTPFSLLLLDLDHFKAINDGHGHDAGDRALQHVAGVLGQLTRGSDYLFRYGGEEFVVVLVAASESQAAVIAESLRRQIAQSPVPLANGQVLSLTASIGVAGHDGHPDYERLMARADAAMYEAKRSGRNRVVVASADLQEAPGRRALQR
>NZ_AP021867.1|WP_153675156.1|1393392_1394610_+|MFS-transporter
MSAAPLPRPLLVLLAVAAGASVANVYYAQPLLERLAQAFALDPALAGAVLAATQAGSVLALLGLLPLADRGDRRRLLRLQLMALVVALLWLAAARTAVWLLSGMLLAGLLGTALTQGLIAYTASLAPAQQRGRVVGMVQGGVFIGLLLARVVSGGVAAAVGWRAVYLLSAALMAALALLLWRRLPAVPVPVVPPGWRALMGSMLGMLRDDRTLRERGPLALLLFAGLNVFWAAAPLPLSAPSLHWSTAAIGALGLAGVIGALLAARVGHWMDRGFAHRVSLGALLLMLVAWCPLLGLPHSVGMLLLGVVVLDLGGQALHVSNQALLLRAPGEQHGRMVALYMLFYALGSGAGAAAGTWMQARHGWPAVCLLGAGIALLALLWWAAWRVVAVKAAAGARIGNADCR
>NZ_AP021867.1|WP_153675155.1|1392865_1393315_-|winged-helix-turn-helix-transcriptional-regulator
MHADSPCPVARSADLLGDRWALLVIRDAFDGVTRFGDFQRSLGAARNILSDRLRRLVEAGILRLQPASDGSAYQEYVLTAAGLELFPLLVALRQWGERHRFEAGEAHSQLIESSTRRPLPYMQPRGRDGEPLAASATRVRKLKDESGSS
>NZ_AP021867.1|WP_153675153.1|1391664_1392792_-|metallophosphoesterase
MSRYRPSLLTALLLPVLACAAATTQAREVAAPAAHVDADGPYVFRQGEQLQAKWICADKVESRTLPATATGTDIATRCGYGHTVHVAAPNAPSISVLPAAPRIVALSDIHGQYGLLVRLLRANQVIDAQDRWALGKDTLVIAGDVFDRGPQVTEAFWLLYGLQQQAAAAGGAVHFVLGNHETMVLYDDLRYVNPKYLRSAQLLGRSYPQLYGADSVIGQWLRTRPVLLKIGATLFLHGGISPEAVELALEPARTNAAYQASLGLPKAEVKADPATAPLYDGKTSPIWYRGYFDGRLDTQGVQAVLDRLQLKRIVVGHTSMPHVSSFHGDRVIAIDSSIKNGENGELLFIENGTLSRGLLDGTRVPLAQGEPGLQD
>NZ_AP021867.1|WP_004150098.1|1390848_1391532_-|response-regulator
MRVLIAEDDPDIASGLCASLRRQGHVVDHVDNGAHADAALGSTQYALLVLDLGLPQLDGRDVLQRLRQRGDGLAVLVVTARDGLAERVRVLDLGADDYLVKPFALDEFEARVRAQLRRVTSNGNPDLRIGRLRLDLAGHRVWIDEQSLELTAREFGLLSALAVRAERIVSRAQLVEALCDWGQDLTDNGLDIALHRLRRKLQPGGIGIRTVRGLGYMLEDAQDDSTP
>NZ_AP021867.1|WP_012510466.1|1389472_1390852_-|sensor-histidine-kinase-N-terminal-domain-containing-protein
MISGPPSLRRRLLAFLALPMLGLLIFNTVLAYYVALDYSNRIHDRNLIDDTHSFAQMLSTMPVTSDLSPQARFLIEYDPDGHRYFNVDSSRKGTLSGNADFSPYAPSQDCTGVHPALYDGTLNGQQVRMATVCTQAMNDPQDQLAVTVAESMADRRQRAREILMIIIPLMTMLALGTAALVWFGVTYGLRILTPLTTRLAQRRGELAPISDADVPEEIQPLISTIDGLFARQAEMITLQNRFIADAAHQLRSPLAGMALHVDQALAHGDPDTVREALQHIRRLNQRTARVSTQLLALSRAQTVPETVEALDLGTLLPQWVGTRVPEAIRDGIDLGYRGSSQPLRVLGNGALLQEALDNLIDNALRYAGRGATVTVGVQALDDNDVELYVEDNGPGVPEDVMPRLGERFFRAPGTTASGTGLGLAIAHEAVEHFGGRLGFLNRAGGGLKVTITLPLLKAP
>NZ_AP021867.1|WP_153675151.1|1388555_1389392_-|alpha/beta-fold-hydrolase
MTETHDFFLPGGPQGVLLVHGLTGTPAEMRMLGKGLNNAGFTVHGVQLPGHCGSVDDLLATTWEQWYQGVEDAAAALRGKVDQLFVGGLSMGAVLSLALAARRPEWVSGVGVYGATFRYDGWNIPAVARFSFLLPWFKRFNIGRDRMFMEEPPYGLRDERLRAQVSAAMLSGDSAAAGLPGNPWHALAEMRALSNWTRRHLHQVTAPCLVMHAREDDVASMGNAELVMSRISGPKELVVLEDSYHMITIDRERRDVIRRSARFFSEIGERSGILKAVA
>NZ_AP021867.1|WP_012510464.1|1388194_1388554_-|EamA-family-transporter
MGSLATLLWLVNVVLDTGGQLAFKAAASDPNEAEGLQRWKHMLSRPWLWLGIACYVLEFVAWIAFLSLVPLSKGVLLGSINIVALMIAGRILFREKLTPLRVTGMLLVTAGVAVVGAGS
>NZ_AP021867.1|WP_153675149.1|1387799_1388198_-|EamA-family-transporter
MRRLYVIGFPLLMAFDTLAQLCFKYAGDAALPVEANTAWLLRVLSQPWVYGAILGYVGAFFTWMSLLRHAPIGPAFAASHLEVISVLLLSAWLLNEPLTLHHLLGAVLTVAGIVCLGRAEADDPHSPAETTT
>NZ_AP021867.1|WP_012510471.1|1398879_1399860_+|cation-transporter
MGHDHDHLPSEIRHEKPLWWALGLTSTFLVVEVVGAFWTNSLALLSDAAHMATDALALMIALVAVRLSRRPPDARRTYGYARLEALGAMINGAMLFVVAGYILWEAIGRFREPQEIASSGMLVIAAAGLVINLISMRLLQAGSGESLNVKGAYLEVWADMLGSVAVIAGALLIKWTGWKPIDPILAVLIGLWVLPRTYVLMREAINVLLEGVPKGMDVAKVRDSLSGHAAVMDVHDLHVWALASSTPALTAHIVMRDGTDADSLRRELGGRLHDDFGIEHVTLQIEADHCGEACGEPAPAKGGEHEGHEGHDHGEDAQGHRGHVHR
>NZ_AP021867.1|WP_012510472.1|1399984_1400668_-|deoxyribonuclease-V
MNTVIDPGRWEGSVAAAREQQIQLAGRVERQDRLPRTVRWLAGLDVGFEDDGATTRAAAVLLDAKTLLPVTQEIARIPTVMPYIPGLLSFRELPALLAALALLPRAPDLVFVDGHGISHPRRLGIAAHLGVVTDLPSIGVAKSKLVGRFVEPGAEAGSHTPLLDGDEQLGWVLRSKVKCKPLFVAGGHRVSADTALHWVQRTLRGYRLPEPTRLADRLASRRGRVDC
>NZ_AP021867.1|WP_004150217.1|1400762_1401512_+|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase
MTRKLVLLRHGQSQWNLDNRFTGWVDVDLTEQGRREAAAAGRLMREEGLQFDVAHTSVLKRAIHTLQGALAELEQDWLPVNKSWRLNERHYGGLQGLDKAETAAKHGEDQVKVWRRSYDIPPPAMDLEDPGHPIHDRRYAGLDRNALPGTESLATTLDRVLPYWHDAIAPQLKDGKTVLVTAHGNSLRALYKYLNNVSREEILELNIPTGIPLLFELNDDLTVKSFRYLGDPEAARKAAEAVANQGKAK
>NZ_AP021867.1|WP_100468075.1|1401672_1403766_+|M13-family-metallopeptidase
MNFRNLAPLGLTIAIAASLAACGKNETAPAANADAKPAFDQSQIKTALISLNGADLDPAISACTDLNGFVNSKWLKANPVPGDQTTWGSFEILRERSLEVQHALVQQAAASQAKAGSVEAKIGDIWKTGNDEAKIEAAGLAPLQPQLDKITALNDTAAITQYLRDSQAEGRGVLFSLFANADYKDSANVIAYVGQGGLGLPEKGYYFDDAQAKIRDAYVAYIAQVLTLSGVDAAQAAEQAKAVMAFETRLAKASMSRIEMRDPAKRYNPLSAADADKLTPNFSWTALFDTLKVPAAQKFSLAQPGFFGEMDKMLADVPAATWQAYLRFHTIDDASPYLSSQFEKANFEFFGKTLRGQQEMQPRWKRVLESVNGGMGEALGQLYVDAVFPAESKVAMQHLVENLSVALKARLEQLPWMGEETRKKALEKWASFTPKIGYPDKWREWTGLQTNADSYLGNMQAARAFNYRYMLDKIGKPVDKSEWGMTPQTVNAYYNATKNEIVFPAAILQAPFFDAKADPALNYGGIGAVIGHEMMHGYDDSGSQFAANGNFDNWWTDADRKAFTERTDQLVAQFDGYESVPGVFVKGKLTLGENIGDLGGLTVAYDALQMALKEDPKANVEVDGHSQDQRFFMNWATVWRRNFTDGELRVRLNTDPHAPANFRANGAPSNMPSYAAAFQCKAGDAMVRADDKRVVIW
>NZ_AP021867.1|WP_100468076.1|1403858_1404476_-|HD-domain-containing-protein
MTMFPDAVPAPDLLHAQACLIDALSMSLQMRDAYTRHHCDRVGLLAQRLATHCDLDDDACSQIGLAARFHDIGKIGIPDDVLLAPRRHTDEERAIMREHPVRGEHIFMATGRSDAVPVARLIRTHHEAFDGSGYPDGLRGEDIPLGARIVTIADAYDAMTSVRPYRTAMEHEKVLRIIDEQSGGLIDPYVLQRFHRMLAQEPALA
>NZ_AP021867.1|WP_100434309.1|1404522_1407987_-|transcription-repair-coupling-factor
MSRTSYPAPPLPRAGQLRAWWRAPASPTALAWYLAQAARAHDAPLLVIARDNHGANQLEADLQTLLGGDPALPVVAFPDWETLPYDRFSPHPDIISQRLSALHRLPELKRGLVIVPVQTLLQQLAPRSYVIGGSFDLKVGQRLDLEAEKRRLESAGYRNVPQVMDPGDFAVRGGLLDVYPMGAEEPLRVELLDEDIDSIRAFDPESQRSLDKVEAVHMLPGREVPMDEASIARVLATLRERFDVDTRRSSLYQDLKSGLAPAGVEYYLPLFFERTATLFDYLPEGSLPVVCVGAGEAAETFWAQTAERYEQRRHDVERPLLPPSALYLSPELLRERLNDAPRIEVWAADHARIADAHALGDQPLPPLPVAAREAPAGDALKSFLGHYPGRVLIAADSPGRREALLEVLQAAELKPPVVADLPSFLADDARFAIAVAPLEDGFALDDPRIAVLTERQLFPERAGSTRRTRRAGREPEAIIRDLGELTEGAPIVHEDHGVGRYRGLIAMDVGGMPGEFLEIEYAKGDRLYVPVAQLHLISRYSGASAETAPLHSLGGEQWSKAKRKAAEKVRDVAAELLEIQARRQARAGLALQVDRAMYEPFAAGFPFEETPDQLAAIDATLRDLASSQPMDRVVCGDVGFGKTEVAVRAAFAAASAGKQVAVLVPTTLLAEQHYRNFRDRFADYPMKVEVLSRFKSTKEIKAELEKVAAGTIDVIVGTHRLLQPDVKFKDLGMVIVDEEQRFGVRQKEALKALRANVHLLTLTATPIPRTLNMAMAGLRDLSIIATPPPNRLAVQTFITQWDNALLREAFQRELARGGQLYFLHNDVESIGRMQRELSELVPEARIGIAHGQMPERELEKVMLDFQKQRFNVLLSTTIIESGIDIPNANTIIINRADRFGLAQLHQLRGRVGRSHHRAYAYLVAPDRRSITPDAEKRLEAIASMDELGAGFTLATHDLEIRGAGELLGEDQSGQMAEVGFSLYTELLERAVRSIKQGKLPDLDAGEEVRGAEVELHVPALIPEDYLPDVHTRLTLYKRISSARDSDALRELQVEMIDRFGLLPDAAKHLFAIAELKLKANTLGIRKLDLGENGGRIVFESKPNIDPMAVIQLIQKQPNLYAMEGPDKLRIKHPLPLPEDRFNAARALLTTLAPG
>NZ_AP021867.1|WP_004150340.1|1408136_1408682_-|N-acetyltransferase
MATRNRMPPWHEIFKAPSGHELLIRPIRPEDGAPLQAAFSLFGPEEIRDRFLQAVTELSPETTQRLTHPNPKTEITLVAAESLPAGEAVVGAVARASIIPGTREAEYAILISRFLIGQGLGRQLMRKLVKWGRGKYLDRLYGDVAAENEPMKQLAASLGFKPVPHPTGAEGLVRMVLELDN
>NZ_AP021867.1|WP_004150342.1|1408777_1409635_-|23S-rRNA-(adenine(2030)-N(6))-methyltransferase-RlmJ
MNYRHAFHAGNHADVLKHIVQLALIDSFKRKDSPFFVLDTHGGAGRYLLASEESRKTLEAESGIMRLMAQPKLPEVVERYLKAVQAGNPVGAMTNYPGSPLLSAQAMRAQDRMAVCELQEAETATLKALFAHDSRVGVHPGDGYALLRSLLPPKFNGSKIGRGLVLIDPPYEAQDAEYQAVLAALAETLARWPQATCAVWFPIKQRRTILHFLRKASALPVKSAMTIEFLVRPDDSPLRLNGSGMLLLNPPWQFDRVVGPALPALRQHLGEPGASTRLDWLKAPE
>NZ_AP021867.1|WP_012510476.1|1409670_1410399_+|two-component-system-response-regulator-CreB
MLRAMTAPVAHVLLVEDEAAIAETVLYALRSEGYAASHCLLGGEALLRLQAGGIDVVVLDVGLPDLGGFEVCRRLRALPGPEAQLPVIFLTARNDEVDRVLGLELGADDYMTKPFSPRELVARVRARLRRALPAVSATASTEGGWQELGTFAIDREGRRIRFRGQALDLTRYEYALLEALLQRPGAILSRAQLMDRGWDSSADSADRTVDTHVKTLRAKLRAAGASDDPIRTHRGLGYALEV
>NZ_AP021867.1|WP_004150402.1|1410402_1411863_+|two-component-system-sensor-histidine-kinase-CreC
MRLVLKLFLGFFLITGIAAFFVMRVFVNEVKPGVRQAMESTLVDAANVLAEMAAADVKDGTIRSGSFTRNLAKARQRDLKAMVWRFPKRSLDYRVTITDAKGIVIYDSLGRDLGRDNSRWNDVYRTLRGEYGARSSPEIAGEEGDTVMHVAAPVYDPVDGRTLIGVLSLAQPNRSIDPFIAASQRAIIERGAWLIGLSALVGVLVTMWLTTGLGQLSRYARAVTAGEPVPPPRRRRDEIGDLGQALETMRRKLEGKAYVEQYVQSLTHEMKSPLAAIRGAAELLQEPLPEADRVHFARSIVDQQERLTETIDKLLALAEVEQHGWLQTRDPIAVPVLLADAAAAAQVRAQAAGVQVRIGSVPDLRVQGDTYLLRQALHNLIDNAIAFSPAGADIALHADLDGQGVRLQVADRGAGIPDYARERIFERFYSLARPGSGRRSSGLGLPFVQEVARLHDGRASVDDREGGGTVASLWLPLVVPGQRPRR

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Crispr_ID: NZ_AP021867_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP021867_6

1845958-1846050

Orphan

Consensus_repeat	Method
TCGACCAAGGTCGACACCTACCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP021867_6

>merge|NZ_AP021867|6|1845958-1846050|CRISPRCasFinder
TCGACCAAGGTCGACACCTACCAACGCGGAGCGATACGACCCAGGTCGACACCTACCTGAGCGGGGCGATACGACCAAGGTCGACACCTACCA

>NZ_AP021867|6|6|1845958-1846050|CRISPRCasFinder
TCGACCAAGGTCGACACCTACCA	ACGCGGAGCGATACGACCCAGGTCGACACCTACCTGAGCGGGGCGAT
ACGACCAAGGTCGACACCTACCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP021867.1\|WP_153675319.1\|1841851_1843051_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341031
NZ_AP021867.1\|WP_100434452.1\|1840981_1841779_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380379
NZ_AP021867.1\|WP_012510766.1\|1853375_1853969_-\|TIGR00730-family-Rossman-fold-protein	unknown	unknown	gnl\|CDD\|129813
NZ_AP021867.1\|WP_004153267.1\|1836982_1837498_+\|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl\|CDD\|237625
NZ_AP021867.1\|WP_012510756.1\|1835854_1836919_+\|heat-inducible-transcriptional-repressor-HrcA	unknown	unknown	gnl\|CDD\|234621
NZ_AP021867.1\|WP_153675332.1\|1855894_1856962_+\|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	unknown	unknown	gnl\|CDD\|234666
NZ_AP021867.1\|WP_153675317.1\|1833036_1833954_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176169
NZ_AP021867.1\|WP_004153270.1\|1839758_1840889_+\|molecular-chaperone-DnaJ	unknown	unknown	gnl\|CDD\|236757
NZ_AP021867.1\|WP_012510764.1\|1849749_1850373_-\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|183566
NZ_AP021867.1\|WP_004153277.1\|1843769_1844678_+\|pyridoxal-kinase	unknown	unknown	gnl\|CDD\|238578
NZ_AP021867.1\|WP_153675327.1\|1848129_1848726_-\|YigZ-family-protein	unknown	unknown	gnl\|CDD\|224653
NZ_AP021867.1\|WP_012510768.1\|1857088_1858219_+\|tRNA-guanosine(34)-transglycosylase-Tgt	unknown	unknown	gnl\|CDD\|234642
NZ_AP021867.1\|WP_153675321.1\|1844674_1845799_+\|prephenate-dehydrogenase	unknown	unknown	gnl\|CDD\|181561
NZ_AP021867.1\|WP_012510755.1\|1834078_1835740_-\|DNA-repair-protein-RecN	unknown	unknown	gnl\|CDD\|223571
NZ_AP021867.1\|WP_153675329.1\|1848766_1849753_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_AP021867.1\|WP_004153292.1\|1854187_1855684_-\|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|99735
NZ_AP021867.1\|WP_153675323.1\|1846099_1846294_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_153675331.1\|1850515_1853356_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|236645
NZ_AP021867.1\|WP_012510757.1\|1837678_1839604_+\|molecular-chaperone-DnaK	unknown	unknown	gnl\|CDD\|234715
NZ_AP021867.1\|WP_153675325.1\|1846364_1848137_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|131259

Protein	Function_ID	Function_description	E-value
NZ_AP021867.1\|WP_153675319.1\|1841851_1843051_+\|MFS-transporter	gnl\|CDD\|341031	cd17478, MFS_FsR, Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters. Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.24373e-105
NZ_AP021867.1\|WP_100434452.1\|1840981_1841779_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|380379	cd06124, cupin_NimR-like_N, AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain. This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	4.53479e-35
NZ_AP021867.1\|WP_012510766.1\|1853375_1853969_-\|TIGR00730-family-Rossman-fold-protein	gnl\|CDD\|129813	TIGR00730, LOG_family_protein_YJL055W, TIGR00730 family protein. This model represents one branch of a subfamily of proteins of unknown function. Both PSI-BLAST and weak hits by this model show a low level of similarity to and suggest an evolutionary relationship of the subfamily to the DprA/Smf family of DNA-processing proteins involved in chromosomal transformation with foreign DNA. Both Aquifex aeolicus and Mycobacterium leprae have one member in each of two branches of this subfamily, suggesting that the branches may have distinct functions. [Hypothetical proteins, Conserved].	7.8209e-54
NZ_AP021867.1\|WP_004153267.1\|1836982_1837498_+\|nucleotide-exchange-factor-GrpE	gnl\|CDD\|237625	PRK14147, PRK14147, heat shock protein GrpE; Provisional.	7.0068e-98
NZ_AP021867.1\|WP_012510756.1\|1835854_1836919_+\|heat-inducible-transcriptional-repressor-HrcA	gnl\|CDD\|234621	PRK00082, hrcA, heat-inducible transcription repressor; Provisional.	6.5122e-139
NZ_AP021867.1\|WP_153675332.1\|1855894_1856962_+\|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	gnl\|CDD\|234666	PRK00147, queA, S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional.	0
NZ_AP021867.1\|WP_153675317.1\|1833036_1833954_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176169	cd08480, PBP2_CrgA_like_10, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 10. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.1382e-96
NZ_AP021867.1\|WP_004153270.1\|1839758_1840889_+\|molecular-chaperone-DnaJ	gnl\|CDD\|236757	PRK10767, PRK10767, chaperone protein DnaJ; Provisional.	0
NZ_AP021867.1\|WP_012510764.1\|1849749_1850373_-\|RNA-polymerase-sigma-factor	gnl\|CDD\|183566	PRK12513, PRK12513, RNA polymerase sigma factor; Provisional.	1.31222e-83
NZ_AP021867.1\|WP_004153277.1\|1843769_1844678_+\|pyridoxal-kinase	gnl\|CDD\|238578	cd01173, pyridoxal_pyridoxamine_kinase, Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and require its precursors in the form of vitamin B6 (pyridoxal, pyridoxine, and pyridoxamine) from their diet. Pyridoxal kinase encoding genes are also found in many other species including yeast and bacteria.	1.51408e-90
NZ_AP021867.1\|WP_153675327.1\|1848129_1848726_-\|YigZ-family-protein	gnl\|CDD\|224653	COG1739, COG1739, Uncharacterized conserved protein [Function unknown].	3.28306e-59
NZ_AP021867.1\|WP_012510768.1\|1857088_1858219_+\|tRNA-guanosine(34)-transglycosylase-Tgt	gnl\|CDD\|234642	PRK00112, tgt, queuine tRNA-ribosyltransferase; Provisional.	0
NZ_AP021867.1\|WP_153675321.1\|1844674_1845799_+\|prephenate-dehydrogenase	gnl\|CDD\|181561	PRK08818, PRK08818, prephenate dehydrogenase; Provisional.	0
NZ_AP021867.1\|WP_012510755.1\|1834078_1835740_-\|DNA-repair-protein-RecN	gnl\|CDD\|223571	COG0497, RecN, ATPase involved in DNA repair [DNA replication, recombination, and repair].	0
NZ_AP021867.1\|WP_153675329.1\|1848766_1849753_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	4.90934e-09
NZ_AP021867.1\|WP_004153292.1\|1854187_1855684_-\|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|99735	cd00610, OAT_like, Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, alanine-glyoxylate aminotransferase, dialkylglycine decarboxylase, 4-aminobutyrate aminotransferase, beta-alanine-pyruvate aminotransferase, adenosylmethionine-8-amino-7-oxononanoate aminotransferase, and glutamate-1-semialdehyde 2,1-aminomutase. All the enzymes belonging to this family act on basic amino acids and their derivatives are involved in transamination or decarboxylation.	2.37593e-38
NZ_AP021867.1\|WP_153675331.1\|1850515_1853356_+\|EAL-domain-containing-protein	gnl\|CDD\|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	9.74861e-93
NZ_AP021867.1\|WP_012510757.1\|1837678_1839604_+\|molecular-chaperone-DnaK	gnl\|CDD\|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NZ_AP021867.1\|WP_153675325.1\|1846364_1848137_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|131259	TIGR02204, system_ATPase_and_permease_component, ABC transporter, permease/ATP-binding protein. This protein is related to a Proteobacterial ATP transporter that exports lipid A and to eukaryotic P-glycoproteins.	0

>NZ_AP021867.1|WP_153675321.1|1844674_1845799_+|prephenate-dehydrogenase
MSGLQERAPRTVGIIGSAGAYGRWLTRFFQQHMQLQVIGHDPADATSHTPEQLLAQADVLVFSAPIRHTPELIAEYVRQSAGRERDRLWLDVTSVKEAPVQAMLASQAEVVGLHPMTAPPKAPTLKGRVMVVCEARLQHWQPWVDALCAALQAECVRATPQHHDQMMALVQAMVHATHLAQAGVLRQYQPQLGDLAAMMPYRSASFELDTAIISRILSLNPAIYEDIQFGNPYVAPMLERLVGQLQALQVQVGRGDDTARAAFREQSLSANHNAFGEQALAAGNYTFERVGYLLADLTERNALSVHLPEDRPGSLRELLNVFEQHRISLASIHSSRTPGGEVHFRIGFVAGSDPAAIALAAAEVDASGIGRVLG
>NZ_AP021867.1|WP_004153277.1|1843769_1844678_+|pyridoxal-kinase
MSESLDNHLVHGRRQRPDGPSPIDVISVQSQLVYGHAGNSAAVPPMRALGVRVAEIPTVLLSNAPFYDTTRGRVLPADWFADLLLGTRERGLPQRAKMLVSGYFGSTANGAAFADWLDEILPACPQLRYCLDPVIGDTHTGPYVEPGLEAIFAERLLPHAWLVTPNAFELNRLTGMPALAEADAIAAARTLLDRGPHWVIAHSVGGNPGELVTLAVGREETWRWTSPLLPVDVAGTGDVLMSLVVSFLLRGESMQQAISRAIAGTHAALEATLDNGFEEFDVIAAAPAALAEGTRFRAERVA
>NZ_AP021867.1|WP_153675319.1|1841851_1843051_+|MFS-transporter
MSTLASPATTSRPVAPGVLAAISTSHVVNDMMQSLILAIYPVIKGGFNLSFTQIGLITLTYQLTASIFQPLIGIATDRRPAPYSLPIGMASTLCGMLLLGFAPNYTMVLLAAAMVGIGSAIFHPEASRIARLASGGRHGFAQSVFQVGGNFGTALGPLIAAAVIVPYGQHAASWFAGAALIGIALLTYVGRWYALHLGTPRPASTASMAPRHPPRTVARVLAILLVLIFSKYFYMASIGSYFTFYLIHHFGIPVAQAQLHLFAFLVASAAGGFLGGPLGDRIGRKPIIWTSILGVAPFALMLPHADLLWTTVLAVLIGFVLSSAFSAIVVYAQEMMPHRIGMVSGLFFGFAFGMGGLGAAVLGLLADKTSIEYVYHLTAFLPLLGIVAAWLPPSRPAAH
>NZ_AP021867.1|WP_100434452.1|1840981_1841779_-|helix-turn-helix-transcriptional-regulator
MDYRKKDIPCPVRETAPWREVPIQRPVTCRARHYQAGTHISPHKHRRHQLVYAQSGLMVVRSEVGRWVVPSTRAIWVPAGIAHAVDCIAEVHMRSLYVEPEFAPHLPAEAFAIQVAPLLRELLLAASLIEGPHEDDSRDGRVVRLLLDELRRMDALPLHLPEPSDPRLLKICLHIQKHPADDATLQDWAQALAVDVKTIQRHFASELGMTFGQWRQQARLLAAMERLALGDKVIDVALAMGYDSPSAFTSMFKRQLGQTPAAFFR
>NZ_AP021867.1|WP_004153270.1|1839758_1840889_+|molecular-chaperone-DnaJ
MSKRDYYEVLGVARTANDEELKKAYRRCAMKFHPDRNPGDAAAEASFKECKEAYEVLSDGNKRRMYDSHGHAAFEHGMGGGGGPGGPDMNDIFGDIFGNIFGGAGGGGPRQARRGADIGYVMELDLEEAVRGVERRIEIPTLAECGDCDGSGSEDGKVETCNVCHGRGQVRIQRGIFAMQQACHNCGGRGQIIAKPCKTCHGNGRVEEDKVLSVKVPAGVDTGDRIRLSGEGEAGPAGTPPGDLYVEVRVREHAIFQRDGDDLHCEVPIRISQAALGDTVRVATLGGEAEIRIPAETQTGKLFRLRGKGVRSVRSRSEGDLYCRVVVETPVNLTNDQRKLLEQFEATFNGEDARKHSPKSATFIDGVKGFWDRMTS
>NZ_AP021867.1|WP_012510757.1|1837678_1839604_+|molecular-chaperone-DnaK
MGKIIGIDLGTTNSCVAIMDGGKARVIENSEGDRTTPSIVAYTKDGEVLVGASAKRQAVTNPKNTFYAVKRLIGRKFTDAEVQKDIAHVPYSILAHDNGDAWVATSDAKKMAPQEISAKVLEKMKKTAEDFLGEKVTEAVITVPAYFNDSQRQATKDAGRIAGLDVKRIINEPTAAALAYGLDKGDNKDRKIVVYDLGGGTFDVSVIEIANVDGEKQFEVLATNGDTFLGGEDFDNRVIEYLVEEFNKDQGIDLRKDPLALQRLKDAAERAKIELSSAQQTEVNLPYVTADASGPKHLNIKLTRAKLESLVEELIRKSIEPCRVALNDAGLRSSDISEVILVGGQTRMPKVQQAVTEFFGKEPRKDVNPDEAVALGAAIQGGVLGGDVKDVLLLDVTPLSLGIETMGGVFTKIIEKNTTIPTKASQVFSTAEDNQSAVTVHVLQGEREQARFNKSLAKFDLSGIEPAPRGLPQVEVSFDIDANGILHVSAKDKKTNKEQKVEIKAGSGLSEEEIARMVADAEANREEDKKFQELVQARNQADALIHGTRSAITEHGSKVGGDVIGKVEAALADLETAMKGDDKAQIEAKSKVLEEAGQSLFAAASAEQGGAAPGADAGNAGKAQDDVVDAEFTEVKDDKKS
>NZ_AP021867.1|WP_004153267.1|1836982_1837498_+|nucleotide-exchange-factor-GrpE
MNHEHPDIESQQSAADAAAAAGVNDEVERLRAELDQVKADVLRERADLENQRKRVARDIEQARKFANEKLLGELLPVFDSLDAGLKAAGDDAHPLREGLELTYRQLLKVAGDNGLVLLDPTGQPFNPEHHQAISQVPTPGAAPGSVVTVFQKGYLLNERLLRPALVVVAAD
>NZ_AP021867.1|WP_012510756.1|1835854_1836919_+|heat-inducible-transcriptional-repressor-HrcA
MHGSPDQLAPRARHLLRSLIARYIQDGEPVGSQTLARVAGLEVSPATIRNILGDLEDLGLLASPHTSAGRIPTAHGYRVFVDSLLQMQPPGEGELARLRQELAGGGSTQALLGSASELLSAMSHFVGVVSAPRREQFAFRQIDFVALDGRRVLAILVFADNEVQNRVIETRQDFAPGQLEQVANYLNAHFAGLPMAEIRTRLLLELRDARSELEQLLAHSIELAEQALQPPADDMLVAGQTRLMGVQDLSDLERLRELFELFSSKREILQLLERTIQAPGVRIFIGEETGMMPLQGVSLVTAPYTANGQVLGVLGVIGPKRMAYDRMIPLVQATADVLGAAFSPAGRTPGTSDA
>NZ_AP021867.1|WP_012510755.1|1834078_1835740_-|DNA-repair-protein-RecN
MLRHLSIKDFAVVRATELEFGPGMTVVSGETGAGKSLMVDALGFLSGLRADSGVVRHGAARAELSAEFALDQLQAARQWLADNELDDEEQCQLRRVIRADGGSRSWINGRPVTLAQLADLAGLLVEIHGQHEQQALLTRPSQLALLDAYAGNEDERRQVRRAAAAWQTLVDESLALSQQGDVSDRIGFLEHQLRELDREDLEPESIAALGASHRRQAHASALLSACQAASNQLNGDDGSSALDLLQQVRHELSRLIEHDPRLGEVDGLIENASIQLHEALSLLDRVHDDLDADPEQFEENERRLGRLHDLARKHRVPMDELGAQRERMHAEVEQLRGADERLQRLAGEIDKAVAAWRVQADVLSASRRSAAAELSATTTGIIAELGMGGGQFLIELEPQDAGKPDPQGAERVEFLVAANAGQPPRALRKVASGGELSRISLAIEVAALDLDAVPTMVFDEVDSGIGGAVADIVGQKLRALGEKRQVLCVTHLPQVASKGHAHYRVSKAPVEGMTQSAVEKLDSKAREEELARMLGGVEVSKEARAAARKLLQV
>NZ_AP021867.1|WP_153675317.1|1833036_1833954_+|LysR-family-transcriptional-regulator
MARPDINRSGELEVFVRVIETGGFSAAARTLDMTPSAVSKLVARLEQRLGTRLLQRSTRQLQLTPEGCAFYERGLRVLADLEEAERCASAHAEPRGRLRVNSNVPFGQHFLLPLLPAFLERNPQVGVDLTLNDEVIDLLEQRTDVAVRAGPLKSSSLVARRLGATRMMIVAAPAYAQRHGLPRTPEELQSHNRLDIGHARAMQGWPLLQDGRERMLLPSGNARASNGNALRQLVLGGLGLARLATYQVQEDIAAGRLLPVLEAANPGDLEEVHAVFLGQGGYLPLRVRAFLDFLVETVDLARPLG
>NZ_AP021867.1|WP_153675323.1|1846099_1846294_-|hypothetical-protein
MSFRQFPAVDSNGDSHIIIEFKPEANGSGHNSESTPRYELDDGRQLVRNGREFTTSGGDVRLTI
>NZ_AP021867.1|WP_153675325.1|1846364_1848137_-|ATP-binding-cassette-domain-containing-protein
MTDKDDAPASTPPLRRLGSLRTLWPFVRRHSGLFTAWLMALAVSSAATLSLPPAVKQMIDHGFTSGGQINRAFALLMLVAVVMALGTAARFYFVSLLGEKVVADLRSQLYAHLIQLGAGFHDRSRSGELVSRLTADTELLRSVVGSTMSVALRSTVTVIGSLAMLFVTSPRLAAWSLLGIPLAVLPIIIGARKLRTVARNSQDRIADANSLASETLGAVRTVQAHAREPYERGRFDKALVDAIGAARRRIGAQSLVTASAILLVFGAIVGVLWLGAHDVIDGRLSAGTLGQFVLYALIGGGSVGALAEVWNELQRAAGGMGRIGELLQEDIEIRAPAQPHALPQPLRGEIRFDDVVFHYPQRPDQAALDHFNLHVRPGETVALVGPSGAGKSTVLSMLLRFHDPSAGRICVDGIDVREVDPAELRDQLALVPQQPTLFAASARDNIRYGRLQASDAEVEDAARAAEADGFLRALPQGYDSELGERGARLSGGQQQRVAIARALLKDAPILLLDEATSALDAQSEHGVQQALERLMAGRTTLVIAHRLATVLKADRIVVMDQGRIVAEGTHAQLLAEGGLYAELARLQFID
>NZ_AP021867.1|WP_153675327.1|1848129_1848726_-|YigZ-family-protein
MPDTLAQPVNHTLEVKHSRFIAHAAPIDGAVAAMAFLQQVAVADATHNCWAYRHGQDYRSSDDGEPAGTAGRPILAAIDGQGFDRVMVVVTRWFGGIKLGAGGLVRAYGGAAAECLRTAPRLPLVAMSRLRLLAGFEDLGTLHATLPAFAAEKRDEQFDADGVCLRVELPADQVDALKIRLRDATRDRIRIQDDDQDD
>NZ_AP021867.1|WP_153675329.1|1848766_1849753_-|hypothetical-protein
MNRNDPLTPEERELAQLLGRRAEQEPPAALDAAILAAARAAVDAPAADATASPDAPRVRRTRPRWPAVFGIAASMVFAIGIAWQLRPEPPPVPAGEAQMAAAPAAADVAATEQMIESSAADSAAAAAEPAAAPAMPEAAPVAAPAAAIARERKPAPADATDAPAPAARSMAAEPAADSAFAALPPPPAAAPPAPPAPAAYSAPAPLMAPVVASGSLKARSAGSPESNSVQAEQAPALDRVEITSTKHAAPSRSAPGVMRRGSDAGLSADTVQAEVAADARLPRRQWLQKIRERRDDGQRDLARASLERYIQQYPESRLPRDLRPLLDD
>NZ_AP021867.1|WP_012510764.1|1849749_1850373_-|RNA-polymerase-sigma-factor
MTLALPTTATGYAPPPAGLTLYAVEASALPTDEALMLAWAGGDLRAFESLYARHRKRLFGFLLRQLRDNALAEEIFQDVWQRVISARAGWQPEAAFSTWLFRIAHNRLNDHWRAARHRPAAPADADLRLAAIEDGQTPEAELSEFEQRRRIQLAMEQLPPEQREVLQLRLDQELSLEEIGQITGVGRETVKSRLRYAMDKLRAGLNA
>NZ_AP021867.1|WP_153675331.1|1850515_1853356_+|EAL-domain-containing-protein
MSTHAEPAEEPLHEAVLSTALVRALHALLPETAVVRVGWDDLQLGRGEGGWPPVSGDRPAVPAGIGDGQHGWDYDGARLLLSVEGAIPSPAWWGLARQAMELALQRGRQAGQIKALEEAERLQQALFQIADLAGADLEMGEMLRHVHGVLGTLMYAENCYIVEYDDVRDQIRFLYFADQVDDFVADPSQSHDASEMPRSLTVALLRHGKPLSGPSRELLARVVEQEHDPQRGPESLDWLGVPMLRDGRVCGAIVVQSYEHAARYGESERALLGFVAQHVQTAMDRRQAQVRLEQQVERRTQQLQRANHSLQDEVAERRRAEQLQTALYNIAEMAMSADSLAQFYGRVHGVVGRLLDARNFYIALVNTAGNGLDFVYSVDEHNASRAPRPFSRGLTEYVVRNRRPLLASRAQIDALLANGEVRESGARSHCWLGVPLLRDDEVVGAIVVQSYSQNSTFSVHDQRLLTFVAQNIGTGLARQRDQQRLRSAHAELEKRVEERTRELAEVNEKLLGQIGERLRAEQRLTHQAMHDALTGLPNRLHLLDRLQDALALARREGGPVFAVLFLDLDRFKLVNDSIGHAAGDRMLVEVAKRIVSMAGTDDVVARLGGDEFAVLLQCPQGLAQALDFGQRLLLALQESMWIAGRELFPSGSLGIALWNPRYRTGEELLRDADAAMYRAKAQGHDRCAIFDEDMREQAMRSLDLEADLRRAINNHDFLPFYQPIVRLSDGEVVGHEALLRWQHERRGLLLPGAFLELGEESGLIEQVDWLIYEQVIAGLAEGGHTYVSVNVSPRHFRSAEFSGRLFGLLDAYGADPQRLRLEITEVALLDDGPHTLRILQGLRERGIQVQLDDFGTGFSALSYLHRFPISTLKIDQSFIAGLHGPEVQSTRALVEGVLSLARTLGIETIGEGIETEAQQQTLRELGCDYGQGYLLGRPAPWGCAAV
>NZ_AP021867.1|WP_012510766.1|1853375_1853969_-|TIGR00730-family-Rossman-fold-protein
MKSICVYCGSNAGSKPAYTERALALGDRIARDGMRLVYGGGNVGLMGTVANAVLAAGGEVTGVIPRQLADWEVAHRGLTELEIVGSMHERKSRMFDLADGFVTLPGGFGTMEEIFEMLTWRQLGIGNKPCAFLDVEGFYAPLIGMIDRMVEERFLHPDQRQDLWYGSDIEEMLAWMKNYQPAQASKWIDEKRRAALR
>NZ_AP021867.1|WP_004153292.1|1854187_1855684_-|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme
MSFIERLAPLRSQPGTRLTSGLDDATLTALSANHPQLIAAVDAAAEEFARVQADLGPLLAQDEQAQIDAMQDGFVNFYADDAVTPYVALAARGPWVVTLKGAVLYDAGGYGMLGFGHTPDAVLEAMARPQVMANIMTPSLSQQRFITALRAEIGHRRGGCPFTRFMCLNSGSEAVGLAARIADVNAKLQTDPGARHAGAAIKRVVVKGSFHGRTDRPALYSDSSRKSYMQHLASYRGEDSVITVAPYDEAGLRKVFEDAARNQWFIEAVFLEPVMGEGDPGRSVPPSFYAVARELTRAHGSLLLLDSIQAGLRAHGVLSVVDYPGFEGLDPPDMETYSKALNAAQYPLSVLAVTEHAAQLYRKGIYGNTMTSNPRALDVACATLAQLTPQVRANIAERGAEAVRKLEQLKGELGGLITKVQGTGLLFSCELAPQFKCYGANSTEEWLRQHGINVIHGGENSLRFTPHFGMDSEELDLLVGLVGRALREGPRREQAAAA
>NZ_AP021867.1|WP_153675332.1|1855894_1856962_+|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA
MRAIVDLLPPTALKKSDFNYNLPAELIAQAPLAERSASRLLLVPPAPDAFTDLQVRDLPSLLQPGDLLVFNDTRVIPARLFGQKASGGRVEILIERLLGGQQARAQVGASKSPKAGSRIALDAGGEAEVLGRDGEFYVLQFHVPESLEQWLLHAGRLPLPPYIQREPGMDDRERYQTVFAREVGAVAAPTAGLHFDEPLLAALKDKGVDFGHVTLHVGAGTFQPVRADDLKDHVMHREWLNVGAELVQQVRRTRAAGGRVIGVGTTVVRALESAMRDGELLPFAGETQIFITPGYRIRSVDVMVTNFHLPESTLLMMISAFAGKARVFEAYQHAIAQRYRFFSYGDAMLLFPQAG
>NZ_AP021867.1|WP_012510768.1|1857088_1858219_+|tRNA-guanosine(34)-transglycosylase-Tgt
MSRLQFQLQTRDGRARRGRLTFPRGTVETPAFMPVGTYGSVKGILPDQVRALGAEIILGNTFHLYLRPGLDIIADHGGLHGFCRWDGPILTDSGGFQVFSLAHRRKITEQGVTFASPTDGARVFLGPEESMKIQKVLDSDVVMIFDECTPYPATEDVARRSMELSLRWAQRSRNAHDELGNDAALFGIVQGGVHTDLRSRSADALQAIGFDGYAIGGLAVGEPEDERNAMLDHLDPELPADRPRYLMGVGRPEDLVEGVARGVDMFDCVMPTRNARNGHYFTSFGTVRIRNSQYARDMDPIEPGCGCVACTGGYTRSYLRHLDRCNEMLAPMLGTLHNLFYYEKLMADIRAAIEAGTFLAFRESFYAARGAVAPPL

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Crispr_ID: NZ_AP021867_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP021867_7

2212721-2212840

Orphan

Consensus_repeat	Method
GCTCGCGATCATCCACGCACAGCGTGGATCTACTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP021867_7

>merge|NZ_AP021867|7|2212721-2212840|CRISPRCasFinder
GCTCGCGATCATCCACGCACAGCGTGGATCTACTGACGGCGCCGGCTCTGGTGGGTGCCGACCGTTGGTCGGCACTGATGCCTGCGCTCGCGATCATCCACGCACAGCGTGGATCTACTG

>NZ_AP021867|7|7|2212721-2212840|CRISPRCasFinder
GCTCGCGATCATCCACGCACAGCGTGGATCTACTG	ACGGCGCCGGCTCTGGTGGGTGCCGACCGTTGGTCGGCACTGATGCCTGC
GCTCGCGATCATCCACGCACAGCGTGGATCTACTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP021867.1\|WP_153675566.1\|2213526_2213991_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_065723241.1\|2214865_2216056_-\|chemotaxis-protein	unknown	unknown	gnl\|CDD\|206779
NZ_AP021867.1\|WP_153675561.1\|2207638_2209741_-\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|226951
NZ_AP021867.1\|WP_006366327.1\|2204547_2205768_+\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|340419
NZ_AP021867.1\|WP_006366498.1\|2218491_2218965_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_005416461.1\|2200971_2201379_-\|flagellar-basal-body-rod-protein-FlgC	unknown	unknown	gnl\|CDD\|183634
NZ_AP021867.1\|WP_006366156.1\|2201382_2201778_-\|flagellar-basal-body-rod-protein-FlgB	unknown	unknown	gnl\|CDD\|183628
NZ_AP021867.1\|WP_153675560.1\|2205861_2207634_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NZ_AP021867.1\|WP_153675567.1\|2214109_2214457_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_006366435.1\|2216278_2216893_-\|high-frequency-lysogenization-protein-HflD	unknown	unknown	gnl\|CDD\|234690
NZ_AP021867.1\|WP_006366323.1\|2203815_2204121_+\|flagellar-biosynthesis-anti-sigma-factor-FlgM	unknown	unknown	gnl\|CDD\|274802
NZ_AP021867.1\|WP_153675558.1\|2203083_2203740_+\|flagellar-basal-body-P-ring-formation-protein-FlgA	unknown	unknown	gnl\|CDD\|183625
NZ_AP021867.1\|WP_065723243.1\|2219484_2220297_-\|APH(6)-family-putative-aminoglycoside-O-phosphotransferase	unknown	unknown	gnl\|CDD\|226100
NZ_AP021867.1\|WP_012510996.1\|2218028_2218490_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239647
NZ_AP021867.1\|WP_065723240.1\|2214554_2214767_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_006366257.1\|2201927_2202872_-\|chemotaxis-protein-CheV	unknown	unknown	gnl\|CDD\|223905
NZ_AP021867.1\|WP_153675569.1\|2216889_2218032_-\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NZ_AP021867.1\|WP_006366325.1\|2204117_2204456_+\|flagellar-protein-FlgN	unknown	unknown	unknown
NZ_AP021867.1\|WP_006366596.1\|2219077_2219404_+\|ATP-dependent-Clp-protease-adapter-ClpS	unknown	unknown	gnl\|CDD\|178809
NZ_AP021867.1\|WP_153675563.1\|2209872_2212632_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|236645

Protein	Function_ID	Function_description	E-value
NZ_AP021867.1\|WP_153675561.1\|2207638_2209741_-\|PAS-domain-S-box-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.31785e-40
NZ_AP021867.1\|WP_006366327.1\|2204547_2205768_+\|two-component-sensor-histidine-kinase	gnl\|CDD\|340419	cd16943, HATPase_AtoS-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS. This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.	1.29836e-52
NZ_AP021867.1\|WP_005416461.1\|2200971_2201379_-\|flagellar-basal-body-rod-protein-FlgC	gnl\|CDD\|183634	PRK12629, flgC, flagellar basal body rod protein FlgC; Provisional.	7.08009e-81
NZ_AP021867.1\|WP_006366156.1\|2201382_2201778_-\|flagellar-basal-body-rod-protein-FlgB	gnl\|CDD\|183628	PRK12620, flgB, flagellar basal body rod protein FlgB; Provisional.	9.73308e-80
NZ_AP021867.1\|WP_153675560.1\|2205861_2207634_-\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	2.53244e-97
NZ_AP021867.1\|WP_006366435.1\|2216278_2216893_-\|high-frequency-lysogenization-protein-HflD	gnl\|CDD\|234690	PRK00218, PRK00218, lysogenization regulator HflD.	4.6228e-87
NZ_AP021867.1\|WP_006366323.1\|2203815_2204121_+\|flagellar-biosynthesis-anti-sigma-factor-FlgM	gnl\|CDD\|274802	TIGR03824, FlgM_jcvi, flagellar biosynthesis anti-sigma factor FlgM. FlgM interacts with and inhibits the alternative sigma factor sigma(28) FliA. The C-terminus of FlgM contains the sigma(28)-binding domain.	8.43521e-15
NZ_AP021867.1\|WP_153675558.1\|2203083_2203740_+\|flagellar-basal-body-P-ring-formation-protein-FlgA	gnl\|CDD\|183625	PRK12617, flgA, flagellar basal body P-ring formation protein FlgA.	1.69093e-108
NZ_AP021867.1\|WP_065723243.1\|2219484_2220297_-\|APH(6)-family-putative-aminoglycoside-O-phosphotransferase	gnl\|CDD\|226100	COG3570, StrB, Streptomycin 6-kinase [Defense mechanisms].	1.15554e-76
NZ_AP021867.1\|WP_012510996.1\|2218028_2218490_-\|NUDIX-hydrolase	gnl\|CDD\|239647	cd03675, Nudix_Hydrolase_2, Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.37277e-71
NZ_AP021867.1\|WP_065723241.1\|2214865_2216056_-\|chemotaxis-protein	gnl\|CDD\|206779	cd11386, MCP_signal, Methyl-accepting chemotaxis protein (MCP), signaling domain. Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.	4.90874e-31
NZ_AP021867.1\|WP_006366257.1\|2201927_2202872_-\|chemotaxis-protein-CheV	gnl\|CDD\|223905	COG0835, CheW, Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms].	4.94907e-38
NZ_AP021867.1\|WP_153675569.1\|2216889_2218032_-\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NZ_AP021867.1\|WP_006366596.1\|2219077_2219404_+\|ATP-dependent-Clp-protease-adapter-ClpS	gnl\|CDD\|178809	PRK00033, clpS, ATP-dependent Clp protease adaptor protein ClpS; Reviewed.	8.29365e-43
NZ_AP021867.1\|WP_153675563.1\|2209872_2212632_+\|EAL-domain-containing-protein	gnl\|CDD\|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	7.45651e-105

>NZ_AP021867.1|WP_153675563.1|2209872_2212632_+|EAL-domain-containing-protein
MDQGIIASLLQHPLASALVIVDRTGRPLAANPAAREHGLPATVAAYAPMLEDLRLLAADGGIVACTLPGGPRGHYDGHLRAVHDGAGNLLAFTLSIPEPVPVDGGGRWELALDSAGHSLWDWDIPSDRVVRTPALGDETATEILARVHNEDIGQVRVALDQHLRGLSEQYSAQFRFRQADGQWRWVLDRGRVVARTADGQPLRMVGTHTDIEQQKQLEGLLQEQQLHLSEAQRIASMGSWSFDPDSGLFWWSPELRSLLSLEQGSVPGQRRWLKQLHPRSRGALRAAWRRVWRDGRAANIELELTRGNEPSQHLRLWMQPLLDTDGQPKRLLGQVQNITEQHQTDALIRWRTELLNRVSALGRIGGCEIEVQTRHMQWTEECYRIHGLRKEPISLDQALALYTEDSRSAFEAALVRIAGGGLPEQLDLCFYRQSGLRVWVQVLIELDRRDGLPPRFVVLFRDITREREANERIELLAHYDLLTGLPNRVLLGEQTAEAIEEARDRGTSLAMLFIDLDGFKTINDSFGHATGDALLKAAATRLHQNLRNNDLFGRFSGDEFIVVLRDLAEPEDAGHVARKLIASLAEPLRRGDTTLKVGASVGIAMLGDAQTDFDSLLRAADAAMYAAKEAGRNTYQYYSQDALARIQRRLELEHALHGAIEREEFSLAYQPLLHAHHGEPPAIEALLRWHRPGIGYCSPAEFIPIAEKCGEIVRIGDWVLNEACRQAIAWDRAGLHFDRIAVNVSAVQLRDRGFAERVIEICHAHGWPPQRLELELTESALIRDTDILRHCFDVLERHGVPLAVDDFGTGFSNLNYLNRFPVGRLKIDRSFVQGMLHDSGTAEVTQAIVHLGHALGMKVVAEGVETHQEEDMLRRQGCDEIQGYLYSRPLSPRDLAQWLRQQHAAPGRTDAASEAVLAR
>NZ_AP021867.1|WP_153675561.1|2207638_2209741_-|PAS-domain-S-box-protein
MPAEPTGNAPVPDPRMAQALSRDRRRVVLSYLAMALAWMIATDSAVQALVPDPHQAALWQGLKGSFFALASAGLLYLLLRPLAEHVLHTHARQQASELRLRQMFEGNPGPILVYDLDTLAILDANPAACSTFGWERDELLEQTIDALWPPGQEQALQTKLEAIREAPEELCILRTQLQLRDGSLRQMELRSNAISYDGHNARLLIAIDRTAEDLAQLRRDQALARVEEAHELARIGAWELDPSSGQGRYSKQVYRLLGRRPPEARRWHRFDELLVPADPATASQTEQLLAELCSGEPVQVDVLLPLLAMDGHALMVHLRAASGTDEAGRNRVLGTLQDVTEREQSRRLLREREEQFRELVRVLPDGVVILSDEHVLYANAWAAGLFGYGSHTLLGEPLSALVAATDLVRVRDQLRAGQPHLGPGHSSVVAMQRADGRSFHAGLAVGEVRYGGRDCKLLIVRDLSDSERTRAALETSNRELQAMAGRLFSLQEDERRAISRDLHDDIGQAITAIKLSAYAAQDEDDAQRRGEDLAQIVSLADTTVSKLRDISTLLRPPQLDALGLEAALSWQARVLFRSSPVELLAEIEPLPQRPDNSIEQACFRIAQESLTNALRHARASQVLLQLRDVGQRSLHLQIRDDGEGFDPDGPRGLGLIVMRERAQSVGGHVRIESAHGEGTLIDVHLPYQAASMATIESPEY
>NZ_AP021867.1|WP_153675560.1|2205861_2207634_-|EAL-domain-containing-protein
MWNPNQPPVSIDDAPDRLGAGNPELQVMVTEAASGGTPLMLMHVDIDHFASVNENMSAEVGDQALVLVAQRLQSYLRGRGKLWRHGSDEFLIAVPRTADVPLPEDFAEEIRQQMELPLSVLPYTLFMTGKLGVSLCPEHASSTSRLLDHAEDALYQAAREGGNAVRIHAVDTPPSAHSESIIARQIVDAIPNGELKLRYQPLVSARDGHVVGMEALLRWQSPTLGMLVPERFMRTAERLGIIVQIGTWVLEGALKQARLWRDQGFDDFTIAVNVSTLQLLRPNFFAEVMGVIQASGVPAQMLTLEINESALTNNVNFVHETLANLRNEGISLSLDNFGTGDSSLSALVRYPVDKLKIDRSFIKSAPAGNREAAIARAIIAMGHQLGMTVIANGVESQAQLGFLRRNDCDVFQGYLFGEPMSADAAGMTLRRRYLRPEAFAETRPDRTLLLLDDEENVLRSLVRLFRRDGYRILAAGNVRDAFDLLAINDVQVILSDQRMSDMSGTEFLGRVKMLYPDTIRLVLSGYTDLNTVTDAINRGAIYRFLTKPWNDDELRKHIHQAFRTYEEQRRSNAGPVPAEPVDGGEDRPLR
>NZ_AP021867.1|WP_006366327.1|2204547_2205768_+|two-component-sensor-histidine-kinase
MSAANALVTAPLPPQPVLQALLERLREGLLLFTEDGQVALANPAAQNLLASGEDGALPPPQRLRELLPPDALEQARQHGHWNGSLPLGEGVIIAHLYYHGPVGQGHFLALFRHIEGQEDYERELQQRHAELRQAYLRLNGTQEKLLQSEKMASIGQLAAGVAHEINNPIGYVHSNLGSLQEYLRSLFTVIEAYERALRAPDPKALIPEIDDIRDRLDIDFISRDLPQLMAESREGIERVTRIVRDLKDFSYSGRDESWKLVDLHSGLESTINIIWNELKYKVHLVREFGQLPLVECLPSELNQVYMNLLLNAGHAIAERGTITVRTGVDGDHVWVEFEDTGGGISPELRQRIFDPFFTTKPVGSGTGLGLSISYSIINKHHGRIDLDSTPGVGSRFRVVLPVKQPR
>NZ_AP021867.1|WP_006366325.1|2204117_2204456_+|flagellar-protein-FlgN
MTAAMSEPLQRLAQALDVERQALVEHDVHALIRATGAKLEALRALEGAPPVGEGEQLQELAERNRANGVLLSRRRREVNWALRQLGRTEDASAYDAKGQSHTVTARRPLAVA
>NZ_AP021867.1|WP_006366323.1|2203815_2204121_+|flagellar-biosynthesis-anti-sigma-factor-FlgM
MSQKIDGNLQVPQALRSVTTPANKPGVSSDAPTRPVEAADSLRLTGEATNLQAIERELTTAPAIDAQRVAAVRESLQNGTYKINPDAIASRMLELDQQLHG
>NZ_AP021867.1|WP_153675558.1|2203083_2203740_+|flagellar-basal-body-P-ring-formation-protein-FlgA
MRRVTSLFAIALAVASPWAVSADWQPVASIRAAALSTLAAGSEGEAQVADALRLPRCGGALQVQPTANTTVEVSCPDAGGWRLFVPVKVRRNQTVLVLNRGIGTGETLTAADITTAQRDAARIAGAVLADPNAAIGRIARRPLQAGALLSNNDLVVQRLIRRGDNVALVSRRGSVEVRIAGRAMGDAGENERVSVENLSSRRIVQGTVDAAGDVIVAR
>NZ_AP021867.1|WP_006366257.1|2201927_2202872_-|chemotaxis-protein-CheV
MSHDLLNRIDQRTRLAGHNRLALLLFRLGGRQLFGVNVFKVQEVLRRPELFQVPGLPSQFAGVADVRGRSVPVLDLGLAIGHPEREPDADTAPGYLVVTEFNRSIQGFLVSGVERIVNIAVEDIHPPPELGAESSYLTAVTRFQGELIQVIDVESVLADIAQVRGEAVLDPAMAMPSDGPQLQVLVVDDSRVARQQIRSVLDQLGVGATLLSDGKAALDHLLQIHASGENPAERYAMVISDIEMPAMDGYTLTTEIRRHPGLAGLYVLLHTSLSGVFNNAMVERVGANAFVAKYSPHELADFVLDRLRKVAMAA
>NZ_AP021867.1|WP_006366156.1|2201382_2201778_-|flagellar-basal-body-rod-protein-FlgB
MRNLITDYLGVHAQAMPLREQRMKLIASNLGNADTPGYKAQDLDFDAALRHAQGQDANGLMTTTNEQHYEISSGLNPFQIAREGVQPSLDGNTVDPDAERAAYGRAALEYRASLSFVESKVRSMLTAITGQ
>NZ_AP021867.1|WP_005416461.1|2200971_2201379_-|flagellar-basal-body-rod-protein-FlgC
MSNLPIFDIAGSALQAQSVRMSTIASNLSNADTVAGSADAVYKPLEPIFQAVTSKNDPNITSVKVKEITQSEAAPIKRYEPGHPLADADGYIYQPDVDPVAQMVNLISTSRNYQAGVEMLTTAKELALATLTMGR
>NZ_AP021867.1|WP_153675566.1|2213526_2213991_-|hypothetical-protein
MAFNFEEARETFEQFLIIMDDQIEWLIEQAQLRGVDLDGSLESLDRLETLYTTMAATQLEDEQDGLRIVFARYLGDVVWEHHGGKWTLPLDDPKDINFNMPVIVGHSSCPWLEFNPIHTMRAYSLRPRPGMIRSIVAHSVDPQILDLSDLVEED
>NZ_AP021867.1|WP_153675567.1|2214109_2214457_-|hypothetical-protein
MSTTFMTWLGFAAMVLIAVTFTWCPAYATLRPPRHRPVAFLFGSLLFMLMAFLFAWMPANAISTGHVHLSHHRSGTIDAWRDIEPMTFWLIIVAEYVFGLLIASYSIAGIALMNR
>NZ_AP021867.1|WP_065723240.1|2214554_2214767_-|hypothetical-protein
MTVIRALPSLADNDRPRNASVREQLQQLEDVAREEIRELQQLADARPAPSRADDALLGLAWDLGLDGSSL
>NZ_AP021867.1|WP_065723241.1|2214865_2216056_-|chemotaxis-protein
MYSRIFIRLAAPLALTLLLPFAIGFEWPAALRWAILTTMTLSWLGFAWWTTRAQAHRSPEHARVLREQDQLLTELRSFVGNEIDGSRGEVERARDLIRQAVSSLGGSFDAMNRKSRQQSQALSRIVDRAGDEGNAGLDVARFAQHASNRMEQLVEALEQVSGQSSTTVQHIDQMAQHLDGIFALLEDVKSIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRNLSERSTTFNEQIRKLAHSSKDAIAKVRETVSHMASRDMDRSREARQEAAAMLDNVAQINASLGDGMREVSDCARSIDGSVAEAVRALQFEDIATQALGGVHTHLDRLTAINREAVALQELLHRNGGVFDEEIATALQRTGSRLRELRSEWERPPHKPVAQQSMGAGTVELF
>NZ_AP021867.1|WP_006366435.1|2216278_2216893_-|high-frequency-lysogenization-protein-HflD
MSFTVDDRVLALAGIAQALQQVRRIADTGHSDAAAVRTAVESVFRVDASSPQEVFGDRHALKAGLRLLHNYFRSQGQDPILPKLALSVLQLERRFVQEGETVNKVASGIERAQRQAAELGDSGHPDVLANLGGLYADTISHLKPRVMVQGNPHYLGQAGVVAEIRALLLAAVRSAVLWRQLGGSYWDFLFSRKAMIEAVDRQLA
>NZ_AP021867.1|WP_153675569.1|2216889_2218032_-|tRNA-2-thiouridine(34)-synthase-MnmA
MSTPRVMVGVSGGVDSSVAAWRLVQQGEAVAGLFMQNWADDGSGECRAEDDRRDAVAVCGLLGIPFHFRDFSNEYWQGVFEHFLAEYAAGRTPNPDVLCNREVKFKHFLDAARELGAERIATGHYARVTQRGHQWLLLRGADRSKDQSYFLHQLGQQQLAATLFPIGDLEKTDLRRIARDVSLPTHAKKDSTGICFIGERDFREFLGRYLPAKPGQILDPADGSVIAEHPGVFYFTLGQREGLNIGGVRGRPAAPWYVVGKDVASNVLYVDQDRDSKWMLSNRLRSETAHWIAGAPPARRFECTAQTRYRQPDEPCTVEVLDDGSVLVTFARPQRAVTPGQSLVLYDGDVCLGGAVIAATDAPLEQCLRTTPSPFEVIAA
>NZ_AP021867.1|WP_012510996.1|2218028_2218490_-|NUDIX-hydrolase
MNATPDPRWAPHATVATVVVDGGRVLLVEETIDGRAVLNQPAGHLEPGESLAEAALRETREETGWTVQLTHFIGCYQWTAGDGTTFLRFCYAARPVSHDPAQPLDTGIDRALWLAPDELQAAGERLRSPLVWQVVADYLGGQRHPLSLVREVA
>NZ_AP021867.1|WP_006366498.1|2218491_2218965_-|hypothetical-protein
MKRTLLPALLVALAAAGSAAAAPEGDKAVARHLDKLGYNYEVDEDGDYRLVFDVEGDRTQMVYVRSSVEDFGTHNIREIWSPAYNAKTKQFPVAVANRLLEDSQDAKMGGWVKQDTTAMFVVKIDADATADQLSDAIDAAIRTADAMELELTKKDEF
>NZ_AP021867.1|WP_006366596.1|2219077_2219404_+|ATP-dependent-Clp-protease-adapter-ClpS
MPRESSPDSHHEHGVAVEPARPEVAPPPFYQVMLLNDDYTPMDFVVDVLQQFFTMDLDKATQVMLHVHTRGRGVCGVFTREVAETKVAQVNEYSRMNQHPLLCTMEKA
>NZ_AP021867.1|WP_065723243.1|2219484_2220297_-|APH(6)-family-putative-aminoglycoside-O-phosphotransferase
MSEPYLSRWRLRRDGAAIETPHAQLWPVLTAAGEPAMLKVSSETEEQNSHRLLRWWDGDGAARLLAHEGPAILIERAGGDSLRQRSIEGDDDTCTTILCQVLQRLHRPRSAPPAELVCLRTWFADLLQPRAPLPSLLEQCGLLAAALLQEEQEIRPLHGDLHHDNVLHFGARGWLAIDPKRLIGDRAFDYTTLFSNPDLCGPGIHVATQPERFAARVEQVTALAGLERTRLLRWIAASAGLSAVWFRDDGDPADIDEAVARMALQALAEG

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Crispr_ID: NZ_AP021867_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP021867_8

2425797-2425915

Orphan

Consensus_repeat	Method
CCGGTGAAAGCGGCGCCAACCAAGGTTGGCGACTACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP021867_8

>merge|NZ_AP021867|8|2425797-2425915|CRISPRCasFinder
CCGGTGAAAGCGGCGCCAACCAAGGTTGGCGACTACCGGGCCTGAGCGGTGTTGCTTTGGTAGATGCCCACCTTGGTGGGCGCCGGAGAAAGCGGCGCCAACCAAGGTTGGCGACTACC

>NZ_AP021867|8|8|2425797-2425915|CRISPRCasFinder
CCGGTGAAAGCGGCGCCAACCAAGGTTGGCGACTACC	GGGCCTGAGCGGTGTTGCTTTGGTAGATGCCCACCTTGGTGGGCG
CCGGAGAAAGCGGCGCCAACCAAGGTTGGCGACTACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP021867.1\|WP_153675733.1\|2415692_2416304_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_153676240.1\|2425947_2427036_-\|winged-helix-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|225755
NZ_AP021867.1\|WP_125894837.1\|2431120_2431786_-\|conjugal-transfer-protein	unknown	unknown	gnl\|CDD\|237542
NZ_AP021867.1\|WP_153675743.1\|2425498_2425777_+\|DUF3325-family-protein	unknown	unknown	gnl\|CDD\|371735
NZ_AP021867.1\|WP_153675736.1\|2420332_2421169_+\|SIP-domain-containing-protein	unknown	unknown	gnl\|CDD\|99790
NZ_AP021867.1\|WP_153675737.1\|2421365_2423543_+\|TonB-dependent-siderophore-receptor	unknown	unknown	gnl\|CDD\|273805
NZ_AP021867.1\|WP_153675741.1\|2423891_2425502_+\|PepSY-domain-containing-protein	unknown	unknown	gnl\|CDD\|377164
NZ_AP021867.1\|WP_006369760.1\|2437341_2438076_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237939
NZ_AP021867.1\|WP_153675739.1\|2423595_2423895_+\|DUF3649-domain-containing-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_153675734.1\|2416363_2417080_+\|response-regulator	unknown	unknown	gnl\|CDD\|223816
NZ_AP021867.1\|WP_006369083.1\|2418360_2419287_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372703
NZ_AP021867.1\|WP_153675754.1\|2434121_2436668_-\|TcfC-E-set-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|374909
NZ_AP021867.1\|WP_032970513.1\|2417083_2418160_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_AP021867.1\|WP_153675744.1\|2427105_2427699_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_AP021867.1\|WP_153675752.1\|2432901_2434140_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_006369758.1\|2436736_2437231_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_153675746.1\|2427938_2430134_+\|TonB-dependent-siderophore-receptor	unknown	unknown	gnl\|CDD\|273805
NZ_AP021867.1\|WP_153675735.1\|2419547_2420162_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|172294
NZ_AP021867.1\|WP_153675748.1\|2430300_2430657_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_153675750.1\|2431900_2432848_+\|prolyl-aminopeptidase	unknown	unknown	gnl\|CDD\|130316

Protein	Function_ID	Function_description	E-value
NZ_AP021867.1\|WP_153675741.1\|2423891_2425502_+\|PepSY-domain-containing-protein	gnl\|CDD\|377164	pfam03929, PepSY_TM, PepSY-associated TM region. The PepSY_TM family is so named because it is an alignment of up to five transmembranes helices found in bacterial species some of which carry a nested PepSY domain, pfam03413.	1.44751e-60
NZ_AP021867.1\|WP_153676240.1\|2425947_2427036_-\|winged-helix-DNA-binding-domain-containing-protein	gnl\|CDD\|225755	COG3214, COG3214, Uncharacterized protein conserved in bacteria [Function unknown].	9.65928e-57
NZ_AP021867.1\|WP_125894837.1\|2431120_2431786_-\|conjugal-transfer-protein	gnl\|CDD\|237542	PRK13882, PRK13882, conjugal transfer protein TrbP; Provisional.	7.26133e-74
NZ_AP021867.1\|WP_153675743.1\|2425498_2425777_+\|DUF3325-family-protein	gnl\|CDD\|371735	pfam11804, DUF3325, Protein of unknown function (DUF3325). This family of short proteins are functionally uncharacterized. This family is restricted to Alpha-, Beta- and Gamma-proteobacteria.	1.83047e-10
NZ_AP021867.1\|WP_153675736.1\|2420332_2421169_+\|SIP-domain-containing-protein	gnl\|CDD\|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	1.83069e-46
NZ_AP021867.1\|WP_153675737.1\|2421365_2423543_+\|TonB-dependent-siderophore-receptor	gnl\|CDD\|273805	TIGR01783, Ferrienterobactin_receptor, TonB-dependent siderophore receptor. This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins].	2.65831e-95
NZ_AP021867.1\|WP_006369760.1\|2437341_2438076_-\|hypothetical-protein	gnl\|CDD\|237939	PRK15308, PRK15308, fimbrial protein TcfA.	0.000382252
NZ_AP021867.1\|WP_153675734.1\|2416363_2417080_+\|response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.70057e-67
NZ_AP021867.1\|WP_006369083.1\|2418360_2419287_+\|hypothetical-protein	gnl\|CDD\|372703	pfam13748, ABC_membrane_3, ABC transporter transmembrane region. This family represents a unit of six transmembrane helices.	7.24335e-91
NZ_AP021867.1\|WP_153675754.1\|2434121_2436668_-\|TcfC-E-set-like-domain-containing-protein	gnl\|CDD\|374909	pfam16967, TcfC, E-set like domain. TcfC is a family of bacterial fimbrial proteins. These sit in the outer bacterial membrane surrounding the RcpA proteins of the fimbrial shaft. This family is from Gamma-proteobacteria. This domain represents an immunoglobulin like E-set domain.	8.56476e-19
NZ_AP021867.1\|WP_032970513.1\|2417083_2418160_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.56169e-48
NZ_AP021867.1\|WP_153675744.1\|2427105_2427699_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	0.00129922
NZ_AP021867.1\|WP_153675746.1\|2427938_2430134_+\|TonB-dependent-siderophore-receptor	gnl\|CDD\|273805	TIGR01783, Ferrienterobactin_receptor, TonB-dependent siderophore receptor. This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins].	8.23352e-111
NZ_AP021867.1\|WP_153675735.1\|2419547_2420162_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|172294	PRK13756, PRK13756, TetR family transcriptional regulator.	0.0056438
NZ_AP021867.1\|WP_153675750.1\|2431900_2432848_+\|prolyl-aminopeptidase	gnl\|CDD\|130316	TIGR01249, Putative_proline_iminopeptidase, proline iminopeptidase, Neisseria-type subfamily. This model represents one of two related families of proline iminopeptidase in the alpha/beta fold hydrolase family. The fine specificities of the various members, including both the range of short peptides from which proline can be removed and whether other amino acids such as alanine can be also removed, may vary among members.	3.07479e-132

>NZ_AP021867.1|WP_153675743.1|2425498_2425777_+|DUF3325-family-protein
MIHVILFLLSLAAFACLALAMERHQRDVLHRVLSAQATQQLRAIGWALLVFSAMFAMRGLGVGFGLAALSGHTSVAAGVVVLAMVAHGRWNR
>NZ_AP021867.1|WP_153675741.1|2423891_2425502_+|PepSY-domain-containing-protein
MSKVERSPKPRGIRQTMSDLHIWVGLLAGWILYAMFLTGTASYFRDELSRYTRPEIATPSTLPDAAIVTQRTVATIMADTPAASQINLSLPSTRMPWVSAMWASPGGRGRHGFDSGLFDASTGAPLQARDTGGGDFFYAFHFNLHYMPAMWGRWIVGLCAMFMLVAIVSGVITHKKIFADFFTFRWGKGQRSWLDGHAALSVLGLPFHFMITWSGLVMLAVLYMPWGLAKLPDKRQQAEVVSEMRLFLPPQKAAGQPAPLIDVGALVQQAEQRWGTGSVGSVQVQNPGDQNARVAVVRAQSSRVSTTPNYLLFDGSGGQLLQVKEHSGVAADTQGVLYGLHLGRFADAALRWLYFIVSLAGTAMVGTGLVLWTVKRRAQLPDPQRPYFGFRLVERLNIATVAGLSVAMTAYLWANRLLPVAMDGRAAWEVHVFFLAWAAMFVHATLRTPKRAWIEQFLLAALLLALLPVLTAMTTAHPLWRTLAAGDWAFAGTDLTLLGLAALHTLLAWRTWRHAPKVKRTRPSAASRNAVSEASA
>NZ_AP021867.1|WP_153675739.1|2423595_2423895_+|DUF3649-domain-containing-protein
MSVSRTTTVLAWLPLVSRILAALFGGYVLAALCSIAALALPIDGRQAVFTGMLASFLLYAGAVVWVFAVRSAWRAWLGLIVAALPLWLVAQMVGNGGGA
>NZ_AP021867.1|WP_153675737.1|2421365_2423543_+|TonB-dependent-siderophore-receptor
MSLPARTLPLPRRTALSLAARAALLPALLIATAAHADDAPDGARQLPTVNVRADKTAPTDAYAGGQVTRGSRVGLLGDLDFMDTPFNTTRYTAGFIENIQAPDLVRVIALTDPSVYNSGSSGGITDYFNIRGFGVASSDIGFGGLYGLIPYYRVTPELAENIEVLKGPSALLNGMPPGGSVGGAVNVVPKRAGDTPLTRFTASYSNDAQFGGHLDIGRRFGADKQFGVRLNAVHRDGDTATDHQQHKAQLASLGLDWRGERSQVSLDLFSSRDHVDGLNRGVSLAPGLAVPRPPKASTLFAPDWTFSTVKDQAAALRWSFDINDHLQAHASYGHGHTDFDSVASGTTLITNTAGDFRNNFAHQRFIYSKDTAEAGLSARFRTGPVDHALAISAAWYHHDYKFGFQRNLLARDWVTNIYNPQWGPAIDRSFSNASLPKTGEVRTTSFGIADTLSFIDDRVQLTVGIRRQTVLSDTIDGSTGKRTSRYDTSANTPAAALLFKASDRLSLYANYIEGLSQGSTAPVSAANAGEVFPPYKTRQREVGAKFDFGRLASALSVYEIEKPGSYTDPATNVFSFGGQQRNRGVEWTVFGQATEQLRVLGGIGWLQPKLTRTQGGINEGRLATATPQWQGKLGVEWDVPTLTGLTLTGNAVSLSKGYINADNSQWVAGRTVFDLGARYALQAAGHPLVLRATVQNLTNKAYWAGSLGSGLGTPRTALLSATVDF
>NZ_AP021867.1|WP_153675736.1|2420332_2421169_+|SIP-domain-containing-protein
MSASPTSITPAGPLRGADHDRGLQALQVQVVAVAQPCASLLRLVVQLPEHAELAPWQRANTAVRIQLGATFGDVSRIYTVRSLDPNTRQFTLDVVLHEAPGPILAWVRALRPGDAFDLTGPRPHLQVPQREGTCTLLFADPSAIPALFALMQQWPTGLHAQAWIASDDAFPVDELPAIEGIRVHRLATGDAPLLQQARRLHPDANNTVWAAGEREEMRALRRHFIETVGLPRSDVAVAGYWKRGETTTETDQRRRRNYERVLARGGGLQDLDDLADDI
>NZ_AP021867.1|WP_153675735.1|2419547_2420162_-|TetR/AcrR-family-transcriptional-regulator
MAAPKKTAARGRPPSITRERIADAGIAMTLPGLSFVGVAAALGVSHIALYKHVANLAALRELVAEAIFERWQAPALDADADVSIEADLRAFQCSLRALVDANPGLAPFLVSHGAKTPEMLARIQRHHAEFSRVHGLSLEQAAWLLSTVAYHAVALADTVYSRNAVVDTSRRPLDRKAQQAEFDRSMEALIIGALAMCGRTAASG
>NZ_AP021867.1|WP_006369083.1|2418360_2419287_+|hypothetical-protein
MKPPHDPAAAAGSIGQQNAAATLKAILRTYPWQLTGTFSLVALENALLLAYPLFAGFAVDAIIRGDIGHAISYAGVVLLFWLVGAARRAVDTRTFTRIYADLAVNVVQAQRRLGHATSTSAARVVLAREFVDFFEKHVPIIATALVSMFGAAVMLLVIEPLVGAASLIALLGAVLLMPSFARRNEQLHGRLNNRLEHEIRLVDRVSPSVLRRHYTTLSRLRILLSDREAGAFVVVGAAAAVLFALTIGRLATTDGVTPGHVYAVMTYLWTFVGSLDDAPSMVDQLARLKDIGRRVSPGMEDAEHKDAA
>NZ_AP021867.1|WP_032970513.1|2417083_2418160_+|HAMP-domain-containing-histidine-kinase
MNPKGKSIGRQITLSITVASLCSTVLSISGFYLFYYLMEVFYPRWYDEPETIMPSGLEWLWIGLTASVVVIFATLVASRLTRRIITPLNSVAESLRRVASGDLEARARGGDTSMTEAATLVSDFNSMAERLNRMSENRVFWNAAIAHELRTPMTILRGRLQGIAEGVFEPGPEQFNSMLTQLEGLTRIIEDLRVVSLAESGHLDLRLQRSDVSVQVAAVVEAMSEALTESGFSVTLDARPSLADCDPARIRQAVLALLENARRHAIPCPLRVAVTLAEGHCTVAVEDGGPGVPDELRDSIFEAFQRTDVSRSRQSGGSGLGLAVVRAIAVAHHGTAQCRATERGGSSFEIRWPVHARR
>NZ_AP021867.1|WP_153675734.1|2416363_2417080_+|response-regulator
MKPDTRMRQAPLVLIAEDEGEIADILGAYLARSGLRSVRAVDGEAALASHRQLRPDLVLLDVQMPRMDGWQVLSELRRRGNTPVIMLTALDQDVDKLTGLRVGADDYVAKPFNPAEIVARIQAVLRRSAREPSGAPGGVIRQGPFEIDLRSHEVTVRTDEQLHALTFTLTEFRLLVHMARAPRQVHSRLDLLHNCLPEGDAQERTVDSHVSKLRRKLEDVGVIGIPATIRGVGYRFLD
>NZ_AP021867.1|WP_153675733.1|2415692_2416304_+|hypothetical-protein
MAASLGNLADCLSTVLRPHPDLPSIDVRRAYLAWCAPAPWLLALVLASITVWMLASPHVLPPVLAGFGATALLWFRSDGPGHASRLGSPASLALIGLAVWSETKPTAAGATLHLLLALATLLVAAQMTLRLRAIMRMATRLQARVDAADMASRWARLSAALSALAARDLREGRPLAPSLHRTLVLATLAWAANEEAQAMERRR
>NZ_AP021867.1|WP_153676240.1|2425947_2427036_-|winged-helix-DNA-binding-domain-containing-protein
MPATPTLDDLRRHAVARTLFKPTTLLTAIRRLGFVQADPIRAPARAQDLTLRHRVKDYRAGDLERRYTLLPVEEDCLVNYGFLPREHLALMHPRVSKREWDAETQRRAADVLAFVRERGSVHPREVDQAFAHGRVTNYWGGTSNASTHLLDGMHYRGLLRVQRRDSGTRIYAVADHAEADASEQAQIERAAALIDLVVRKYAPLPSASLTYLVRLLGYGAPHLAEQTRQALMLAKQQLASCTLDGTTWYWPADENPRSRRHAPDEQVRLLAPFDPVVWDRRRFELLWGWVYKFEAYTPAPKRQYGYYALPVLWHDQVVGWANLSVRDGELASSVGYAGKSLARDKVFRGALEDELQRMAAFL
>NZ_AP021867.1|WP_153675744.1|2427105_2427699_-|TetR/AcrR-family-transcriptional-regulator
MNMHPETPASARGRPPTITPDRLADIGIKLGLPNLTMANVAAELAVTQAALYKRVANLEALKRLVADTVFQRWQIPRASVDAPGGLQAYLLAFVESLCEVVKAHPGLPPYLLRRSVATAPMLEKIASHQAHVAEVFGLPLDKARWLLATIAFYCIAGADTVYGIADDEEGQVITEFKQGMRALVIGSLQVLNEDGNL
>NZ_AP021867.1|WP_153675746.1|2427938_2430134_+|TonB-dependent-siderophore-receptor
MTVYHLSSPLQPAAAAASRGQMHPPMARRYRVSVLAMGLLASFAALAESAPSTLPSVQVQEQRRVTGDYAGGQVASGGRVGLLGDKDFMDTPFSTVSYTEAFIRDRQAKDLTDVIAATDPTVFSNGVTGSWSENYAIRGFASSTSDTTFNGLSGMAPYYRTSPEMFERIEVLKGPSALLNGMPPGGSVGGSVNLVPKRAGDQPLLRVSANFASDAQFGTHVDVGRRLGADKQFGIRFNGAYRDGDGAVGKQSKKVQLGSLALDWRGERARLSADLYSADDRVDGPARGVGLAPGVAIPRPPRGDTLINPDWAYVDSQDKGAMLRGELDISDTLMAYLAYGTSKTDYRYNGSISAQILNPAGDFTTVMGQLAFDIKKQSGDAGLRGSFRTGSVGHQWAANVTHYQHTQNDFGRRSVPGWDWTTNLYNPVWGPAAPFIAPHISHTELRLDSIGFADTLSFADDRVQLTLGVRRQQVVSETFNVASGARTSRYDESATTPAAALLVKATDKLSVYANYIEGLSQGATAPMTAANAGDVFAPFRTKQKELGLKLDLGSFAHTFSLYEIKRPSSYTDPVTNIFSFGGEQRNRGVEWGFFGSPLDGVRLLGGVAYVQPKLTRTAGGVNEGRIATAVAQRQAKLGVEWDVPALEGLTLTGNATAMSKQYISADNRLSVPGRTLFDVGARYSTTMAGRPLALRASVNNVTNKAYWGMPLLSSLALGAPRTVLLSATMDF
>NZ_AP021867.1|WP_153675748.1|2430300_2430657_-|hypothetical-protein
MNASEFPHQRAPANADEGHDIPPDPNSLTTLLHRIGLGAAADGQSWPERHQLPGRCMALADADGALAGLRIVQEVLLAAERARQNGSPDQYVGDRVMEGLKLAALALTSHAIFRLQPG
>NZ_AP021867.1|WP_125894837.1|2431120_2431786_-|conjugal-transfer-protein
MQATTAGTSTFNLTLGSGARELLKWIALLTMTGDHVAKVVYGGYLPVISELGRIAFPLFALVMACNLAQPGADLRKSIRRLAVWGVVAQPLHALAFGPWLPLNILLTFALAAVAVHALASNRPLLLLLAAGMAPMLVDYQWAGVGFVLLGWLAFRHGAWWLLLIGLAAVCWANHNGWALLAVPVLLLAARVPWQLPRWRWAFYGYYVGHLAVLALIARLLA
>NZ_AP021867.1|WP_153675750.1|2431900_2432848_+|prolyl-aminopeptidase
MRTLYPAIEPYREFTRPVSDLHTLHIEECGTPDGIPVVYLHGGPGAGISPTHRRFFDPARYRIVLIDQRGSGRSTPFGELRDNTTQDLVADIEKVREHLGIERWLVYGGSWGSTLSLAYAQAHPERATGLIVRGVFLGREMENRWFAEANGGARWIFPERWDRYEAYIPETERGDMLAAYWARLDSADEATRIAAAQAWLGWEDNAATLQHDVDAVSTDDPLDTLAKARIEAHYFRNGIFLEPNQLLRDIDRIRHLPGVIVQGRYDIICPPRSAWDLAKAWPEAKLEMVTSGHSANEPATVDALVRATDAFADRF
>NZ_AP021867.1|WP_153675752.1|2432901_2434140_-|hypothetical-protein
MEVNTVSAREHSSCKLLACGEILLRVVMLLALCVPDTLWAQTAEVDIRARFSPSALDPSHRRFKNDTPQGGICVRWGGHCRAGQFSISTPLGVSGRLLGGSPDSPRQNYFMAVDAQWRDVDVVHEGGSVARVRFRISMLAQRYSRNNSGSPSIYGASSGGCRPLGIDVGSTQWHAWGWVLPVGQLTCSRRTNHAVSSAISVTEISIGYELDTPDPLAMLDGKYTGALAYSVGPGGQIDLGDGAHQQNELTVKFELTVAHDFHIRFSSESPSVQLAPEGGWAKWMDHGLPPTRLRQELLFRLTTSRNLSLKLRCEHEAADRCGIRNPRDDRVVPVDVDVTMPGMSNVADGSPAQDTPLLPDDGRAPHFTPDGYLIERRSTLRFTAGREAVAEMLKSPGSHWQGNMTVVFDANP
>NZ_AP021867.1|WP_153675754.1|2434121_2436668_-|TcfC-E-set-like-domain-containing-protein
MRLPLAPAYPALARLAAGIGAVVFAASSHAAGLALGELPSLLEQRERMPAEFRAHLFGNPLTVRVELDGRYLGDAEVLLHEDNRVHLIGFGEAHDSPWPQTERTRWAEALAEPMALGVCSQQCRGLAALHYSLSNSLLSLLTPAGAHKDGRHVALPETGSHGLIVRNSVAVHGGQEQQTTARYSAELRGSVGRWSTAGSYQYYAQPGSREHYLSALYAQRELGDHFVRAGYFLPTFEGIIRQPRAPGTQNDTALGVMLGSSDVLLADTRSPSVYPVYVTASREGVVEILRDGNLLSTQAVKPGIQEIDTRRLPGGIYDVELRVIEDGHEASREIASIHKPSRWSDPTRRWRYSVFAGQQRGLLDSGRASQDGKLAAGAVVNYLVHPRAVAGATVQQIGTRRAAGLSMDWQASDRFSTYTNAYTSSDAGRGVDLQGLYRYRAGSVVANHARSWAEQRQRVLPGDGSAPRWETRGGWQDTTAVSVTHRFSHRDNASLRVARSSGFTKGTGIDVSYGRRETLFGRHDVNWRVSAYDRPGSRFTRYRRQRGVDLTISVSLGSERRSYSGSLGSRTGEAGQRDTYASAAATQRVDGKLVQTVNGMISAERSGIGTGAGAYLQSSLLEGDVQLYRGAGSGHVSGSANLDSTLVIGGGRAAVLGQGRSGSVDTGIIVDVRSDYPDVMLRGDDSRGGGVELKPGRNFVPVTAYRAGHVQFDFQGRHAPAATLQPSTVSYHLNKGGVMHATVDVLRTFTVMGQVLDADGNGVSGVQVINHAGRSVSQEEGFFTLELSARAPVVELRYPNLVSCVLTMEEGRYPREGDVLMVGGIGCLSQLVQVAPKPRDSEQWRSTR
>NZ_AP021867.1|WP_006369758.1|2436736_2437231_-|hypothetical-protein
MSLKTTLLAAATALLIIPAVALAATETKSITVNVTADVPNSAGLQVSTPDGWEGLPQHLPWDTARQVLGELTGRVINIKSPAAITAYLSAPAQMASAADVVDLAVKLDNVVVPATSAAKITVANAAQAAAGKSLAFAITPTVPTDGYKQGSYGGQFHMIFESDI
>NZ_AP021867.1|WP_006369760.1|2437341_2438076_-|hypothetical-protein
MHRHLSLILLVILSGSAQASTPQINVGVLFDYLQPAHSNLLKRIRNTGDATAYVRVEVTQMHFDTDGRASETPVDTTALVRNRPDAQGVIASPSRLIIAGNGQQATRLVYRGARDEERYYRLRFIPVAPTAEEFSLSEDQAREAAELTSAIRVFTGYGTIFFVAPENPRYDTLIEQQLVRNRGNATVVLDNLRQCERDRPDTCTPGIIAHVRPGNSYALQAAEHQFLRFELREGDSQRSIDSRR

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Crispr_ID: NZ_AP021867_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP021867_9

2442830-2442926

Orphan

Consensus_repeat	Method
GTAGCGCCGGCCGCTGGCCGGCAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP021867_9

>merge|NZ_AP021867|9|2442830-2442926|CRISPRCasFinder
GTAGCGCCGGCCGCTGGCCGGCAACATCGTGCACCGCTTGGTAGGTGCCGACCTGGGTCGGCACAGACCTGGGTAGTGCCGGCCGCTGGCCGGCAAC

>NZ_AP021867|9|9|2442830-2442926|CRISPRCasFinder
GTAGCGCCGGCCGCTGGCCGGCAAC	ATCGTGCACCGCTTGGTAGGTGCCGACCTGGGTCGGCACAGACCTGG
GTAGTGCCGGCCGCTGGCCGGCAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP021867.1\|WP_153675766.1\|2447561_2448413_+\|FecR-domain-containing-protein	unknown	unknown	gnl\|CDD\|226235
NZ_AP021867.1\|WP_032970570.1\|2444105_2444747_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|226932
NZ_AP021867.1\|WP_153675760.1\|2443057_2444113_+\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226654
NZ_AP021867.1\|WP_006369821.1\|2446570_2446837_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_006369762.1\|2438349_2438649_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239300
NZ_AP021867.1\|WP_006369760.1\|2437341_2438076_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237939
NZ_AP021867.1\|WP_153675770.1\|2451009_2451882_+\|L1-family-subclass-B3-metallo-beta-lactamase	unknown	unknown	gnl\|CDD\|293847
NZ_AP021867.1\|WP_125894837.1\|2431120_2431786_-\|conjugal-transfer-protein	unknown	unknown	gnl\|CDD\|237542
NZ_AP021867.1\|WP_006369764.1\|2438942_2439242_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_153675768.1\|2448484_2450914_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NZ_AP021867.1\|WP_032970572.1\|2447040_2447565_+\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|224511
NZ_AP021867.1\|WP_153675754.1\|2434121_2436668_-\|TcfC-E-set-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|374909
NZ_AP021867.1\|WP_153675762.1\|2444743_2445289_+\|DUF1697-domain-containing-protein	unknown	unknown	gnl\|CDD\|377954
NZ_AP021867.1\|WP_153675752.1\|2432901_2434140_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_006369758.1\|2436736_2437231_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_153675764.1\|2445388_2446561_-\|low-temperature-requirement-protein-A	unknown	unknown	gnl\|CDD\|377704
NZ_AP021867.1\|WP_153675756.1\|2439304_2442064_+\|magnesium-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|236705
NZ_AP021867.1\|WP_153675748.1\|2430300_2430657_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_153675750.1\|2431900_2432848_+\|prolyl-aminopeptidase	unknown	unknown	gnl\|CDD\|130316
NZ_AP021867.1\|WP_153675771.1\|2452022_2452562_-\|DUF411-domain-containing-protein	unknown	unknown	gnl\|CDD\|225564

Protein	Function_ID	Function_description	E-value
NZ_AP021867.1\|WP_153675766.1\|2447561_2448413_+\|FecR-domain-containing-protein	gnl\|CDD\|226235	COG3712, FecR, periplasmic ferric-dicitrate binding protein FecR, regulates iron transport through sigma-19 [Inorganic ion transport and metabolism, Signal transduction mechanisms].	2.11158e-54
NZ_AP021867.1\|WP_032970570.1\|2444105_2444747_+\|response-regulator-transcription-factor	gnl\|CDD\|226932	COG4566, TtrR, Response regulator [Signal transduction mechanisms].	4.00808e-84
NZ_AP021867.1\|WP_153675760.1\|2443057_2444113_+\|two-component-sensor-histidine-kinase	gnl\|CDD\|226654	COG4191, COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms].	2.82869e-44
NZ_AP021867.1\|WP_006369762.1\|2438349_2438649_+\|hypothetical-protein	gnl\|CDD\|239300	cd03002, PDI_a_MPD1_like, PDI family, MPD1-like subfamily; composed of eukaryotic proteins similar to Saccharomyces cerevisiae MPD1 protein, which contains a single redox active TRX domain located at the N-terminus, and an ER retention signal at the C-terminus indicative of an ER-resident protein. MPD1 has been shown to suppress the maturation defect of carboxypeptidase Y caused by deletion of the yeast PDI1 gene. Other characterized members of this subfamily include the Aspergillus niger prpA protein and Giardia PDI-1. PrpA is non-essential to strain viability, however, its transcript level is induced by heterologous protein expression suggesting a possible role in oxidative protein folding during high protein production. Giardia PDI-1 has the ability to refold scrambled RNase and exhibits transglutaminase activity.	0.00295319
NZ_AP021867.1\|WP_153675762.1\|2444743_2445289_+\|DUF1697-domain-containing-protein	gnl\|CDD\|377954	pfam08002, DUF1697, Protein of unknown function (DUF1697). This family contains many hypothetical bacterial proteins.	1.5883e-43
NZ_AP021867.1\|WP_153675770.1\|2451009_2451882_+\|L1-family-subclass-B3-metallo-beta-lactamase	gnl\|CDD\|293847	cd16289, L1_POM-1-like_MBL-B3, Stenotrophomonas maltophilia L1, Pseudomonas otitidis POM-1 and related metallo-beta-lactamases, subclass B3; MBL-fold metallo-hydrolase domain. MBLs (class B of the Ambler beta-lactamase classification) are a diverse group of metallo-enzymes that are capable of catalyzing the hydrolysis of a wide range of beta-lactam antibiotics. MBLs have been divided into three subclasses B1, B2 and B3, based on sequence/structural relationships and substrates, with the B1 and B2 MBLs being most closely related to each other. This subgroup of L1- and Pom-1-like MBLs belongs to the B3 subclass. Subclass B3 enzymes are most active with two zinc ions bound in the active site, and have a broad-spectrum substrate profile. These B3 enzymes have a modified Zn2/DCH site (Asp-His-His).	1.91067e-155
NZ_AP021867.1\|WP_125894837.1\|2431120_2431786_-\|conjugal-transfer-protein	gnl\|CDD\|237542	PRK13882, PRK13882, conjugal transfer protein TrbP; Provisional.	7.26133e-74
NZ_AP021867.1\|WP_153675768.1\|2448484_2450914_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	3.63256e-56
NZ_AP021867.1\|WP_032970572.1\|2447040_2447565_+\|RNA-polymerase-sigma-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	2.7028e-22
NZ_AP021867.1\|WP_153675754.1\|2434121_2436668_-\|TcfC-E-set-like-domain-containing-protein	gnl\|CDD\|374909	pfam16967, TcfC, E-set like domain. TcfC is a family of bacterial fimbrial proteins. These sit in the outer bacterial membrane surrounding the RcpA proteins of the fimbrial shaft. This family is from Gamma-proteobacteria. This domain represents an immunoglobulin like E-set domain.	8.56476e-19
NZ_AP021867.1\|WP_006369760.1\|2437341_2438076_-\|hypothetical-protein	gnl\|CDD\|237939	PRK15308, PRK15308, fimbrial protein TcfA.	0.000382252
NZ_AP021867.1\|WP_153675764.1\|2445388_2446561_-\|low-temperature-requirement-protein-A	gnl\|CDD\|377704	pfam06772, LtrA, Bacterial low temperature requirement A protein (LtrA). This family consists of several bacteria specific low temperature requirement A (LtrA) protein sequences which have been found to be essential for growth at low temperatures in Listeria monocytogenes.	2.41705e-98
NZ_AP021867.1\|WP_153675756.1\|2439304_2442064_+\|magnesium-translocating-P-type-ATPase	gnl\|CDD\|236705	PRK10517, PRK10517, magnesium-transporting P-type ATPase MgtA.	0
NZ_AP021867.1\|WP_153675750.1\|2431900_2432848_+\|prolyl-aminopeptidase	gnl\|CDD\|130316	TIGR01249, Putative_proline_iminopeptidase, proline iminopeptidase, Neisseria-type subfamily. This model represents one of two related families of proline iminopeptidase in the alpha/beta fold hydrolase family. The fine specificities of the various members, including both the range of short peptides from which proline can be removed and whether other amino acids such as alanine can be also removed, may vary among members.	3.07479e-132
NZ_AP021867.1\|WP_153675771.1\|2452022_2452562_-\|DUF411-domain-containing-protein	gnl\|CDD\|225564	COG3019, COG3019, Predicted metal-binding protein [General function prediction only].	1.94912e-47

>NZ_AP021867.1|WP_153675756.1|2439304_2442064_+|magnesium-translocating-P-type-ATPase
MSLLNAWFNAFLRSRRAGNLFGRRAMPEAGFGPGSAEAAPFALTTGLVTLSQLDEPRLLAALDSHVDGLSPHEAEERLATLGPNEVDHEKPLPWWRHLWQCYRNPFNLLLTVLAAVSWLTEDIKATVVIGAMVLLSTLIRFVQEGRSNRAAERLKALVGNTARVLRRNPGTEAADVADQYFGAHLHSRRPARLLDLPIRELVPGDHIVLSAGDMIPADCRVLTAKDLFVAQAAMTGESLPVEKFAHPGDGLAGLLEQHNLLFMGTNVVSGTATAVVLATGNRTYFGTLAQRSTATDRAPTAFQAGVNSVSWLLIRFALVMVPFVLLINGWTKGDWTEAFLFALSVAVGLTPEMLPMIVTSTLAKGAVLLSRRKVIVKRLDAIQNFGAMEVLCTDKTGTLTQDKIALERHTDVFGHDSEDVLKFAYLNSHFQTGLINLLDRAVLEHVELQSSLRLSQDYHKVDEIPFDFERRRMSVVVSEREDHHELICKGAVEEMLAVCSTVRENGEDKPLDEQRLARVRQTTEELNEQGLRVVAVAMKETAASQTVYSQADECGLTLVGYVAFLDPPKESAAQALQALAAHGVEVKVFTGDNELVTARVCAQVGLEADTILTGPQIERMDDGALSRALHHHRVFARLTPLHKERLVRELRAQGKVVGFLGDGINDAPALRAADIGISVDSAVDIAKEAADIILLEKNLMVLEEGVIQGRRTFNNMLKYIRMTASSNFGNVFSVLVASAFLPFLPMLPLQLLVQNLLYDISQIAIPFDNVDEELVRKPLKWNPADIGRFMVFFGPISSIFDLSCFALMWYVFDARTAADQGLFQSGWFVVGLLTQTLIVHMIRTPKVPFLQSIAAPPLLVMTGLIMAIGVTLPMSPLAGYFKLHALPTGYWPFLVAILFGYAVLTTVLKKIYIRRYGWQ
>NZ_AP021867.1|WP_006369764.1|2438942_2439242_+|hypothetical-protein
MSYKILYITLRRLIGERDVAALRSHLLQHGPVVFARSLSLGSPRVVADALSLLPISERINVLRHLPYPLRDAMKPLCIGGSQRLHMQPWSPAVLAMRHA
>NZ_AP021867.1|WP_006369762.1|2438349_2438649_+|hypothetical-protein
MTGVRYLSVALALCAGLLLGACSKTQEASKATAAEDVTEVKLIPAYESLDKDKDGIVTLAEVDAVAPDWAERLHACDTDRNKTLSRGEYDVCKQTSTSH
>NZ_AP021867.1|WP_006369760.1|2437341_2438076_-|hypothetical-protein
MHRHLSLILLVILSGSAQASTPQINVGVLFDYLQPAHSNLLKRIRNTGDATAYVRVEVTQMHFDTDGRASETPVDTTALVRNRPDAQGVIASPSRLIIAGNGQQATRLVYRGARDEERYYRLRFIPVAPTAEEFSLSEDQAREAAELTSAIRVFTGYGTIFFVAPENPRYDTLIEQQLVRNRGNATVVLDNLRQCERDRPDTCTPGIIAHVRPGNSYALQAAEHQFLRFELREGDSQRSIDSRR
>NZ_AP021867.1|WP_006369758.1|2436736_2437231_-|hypothetical-protein
MSLKTTLLAAATALLIIPAVALAATETKSITVNVTADVPNSAGLQVSTPDGWEGLPQHLPWDTARQVLGELTGRVINIKSPAAITAYLSAPAQMASAADVVDLAVKLDNVVVPATSAAKITVANAAQAAAGKSLAFAITPTVPTDGYKQGSYGGQFHMIFESDI
>NZ_AP021867.1|WP_153675754.1|2434121_2436668_-|TcfC-E-set-like-domain-containing-protein
MRLPLAPAYPALARLAAGIGAVVFAASSHAAGLALGELPSLLEQRERMPAEFRAHLFGNPLTVRVELDGRYLGDAEVLLHEDNRVHLIGFGEAHDSPWPQTERTRWAEALAEPMALGVCSQQCRGLAALHYSLSNSLLSLLTPAGAHKDGRHVALPETGSHGLIVRNSVAVHGGQEQQTTARYSAELRGSVGRWSTAGSYQYYAQPGSREHYLSALYAQRELGDHFVRAGYFLPTFEGIIRQPRAPGTQNDTALGVMLGSSDVLLADTRSPSVYPVYVTASREGVVEILRDGNLLSTQAVKPGIQEIDTRRLPGGIYDVELRVIEDGHEASREIASIHKPSRWSDPTRRWRYSVFAGQQRGLLDSGRASQDGKLAAGAVVNYLVHPRAVAGATVQQIGTRRAAGLSMDWQASDRFSTYTNAYTSSDAGRGVDLQGLYRYRAGSVVANHARSWAEQRQRVLPGDGSAPRWETRGGWQDTTAVSVTHRFSHRDNASLRVARSSGFTKGTGIDVSYGRRETLFGRHDVNWRVSAYDRPGSRFTRYRRQRGVDLTISVSLGSERRSYSGSLGSRTGEAGQRDTYASAAATQRVDGKLVQTVNGMISAERSGIGTGAGAYLQSSLLEGDVQLYRGAGSGHVSGSANLDSTLVIGGGRAAVLGQGRSGSVDTGIIVDVRSDYPDVMLRGDDSRGGGVELKPGRNFVPVTAYRAGHVQFDFQGRHAPAATLQPSTVSYHLNKGGVMHATVDVLRTFTVMGQVLDADGNGVSGVQVINHAGRSVSQEEGFFTLELSARAPVVELRYPNLVSCVLTMEEGRYPREGDVLMVGGIGCLSQLVQVAPKPRDSEQWRSTR
>NZ_AP021867.1|WP_153675752.1|2432901_2434140_-|hypothetical-protein
MEVNTVSAREHSSCKLLACGEILLRVVMLLALCVPDTLWAQTAEVDIRARFSPSALDPSHRRFKNDTPQGGICVRWGGHCRAGQFSISTPLGVSGRLLGGSPDSPRQNYFMAVDAQWRDVDVVHEGGSVARVRFRISMLAQRYSRNNSGSPSIYGASSGGCRPLGIDVGSTQWHAWGWVLPVGQLTCSRRTNHAVSSAISVTEISIGYELDTPDPLAMLDGKYTGALAYSVGPGGQIDLGDGAHQQNELTVKFELTVAHDFHIRFSSESPSVQLAPEGGWAKWMDHGLPPTRLRQELLFRLTTSRNLSLKLRCEHEAADRCGIRNPRDDRVVPVDVDVTMPGMSNVADGSPAQDTPLLPDDGRAPHFTPDGYLIERRSTLRFTAGREAVAEMLKSPGSHWQGNMTVVFDANP
>NZ_AP021867.1|WP_153675750.1|2431900_2432848_+|prolyl-aminopeptidase
MRTLYPAIEPYREFTRPVSDLHTLHIEECGTPDGIPVVYLHGGPGAGISPTHRRFFDPARYRIVLIDQRGSGRSTPFGELRDNTTQDLVADIEKVREHLGIERWLVYGGSWGSTLSLAYAQAHPERATGLIVRGVFLGREMENRWFAEANGGARWIFPERWDRYEAYIPETERGDMLAAYWARLDSADEATRIAAAQAWLGWEDNAATLQHDVDAVSTDDPLDTLAKARIEAHYFRNGIFLEPNQLLRDIDRIRHLPGVIVQGRYDIICPPRSAWDLAKAWPEAKLEMVTSGHSANEPATVDALVRATDAFADRF
>NZ_AP021867.1|WP_125894837.1|2431120_2431786_-|conjugal-transfer-protein
MQATTAGTSTFNLTLGSGARELLKWIALLTMTGDHVAKVVYGGYLPVISELGRIAFPLFALVMACNLAQPGADLRKSIRRLAVWGVVAQPLHALAFGPWLPLNILLTFALAAVAVHALASNRPLLLLLAAGMAPMLVDYQWAGVGFVLLGWLAFRHGAWWLLLIGLAAVCWANHNGWALLAVPVLLLAARVPWQLPRWRWAFYGYYVGHLAVLALIARLLA
>NZ_AP021867.1|WP_153675748.1|2430300_2430657_-|hypothetical-protein
MNASEFPHQRAPANADEGHDIPPDPNSLTTLLHRIGLGAAADGQSWPERHQLPGRCMALADADGALAGLRIVQEVLLAAERARQNGSPDQYVGDRVMEGLKLAALALTSHAIFRLQPG
>NZ_AP021867.1|WP_153675760.1|2443057_2444113_+|two-component-sensor-histidine-kinase
MPSLSPRRPLVLLALIVVMAAIFLVDTVTDYAVAAACFYAAVILAASRVLAARGLISLAIACIALTALSFFLTRFGTYRIGLVNSVIGMLVIGITTYLALKMEAAKAAVQEAQGRLLRVARASTVGELTTSIAHEVNQPLAAIASSAEACQRWLAQDPPNVDKARQTVARILADAHRAGDVIARIRGLTQGAAPERRAFDLNQAVEEMLALSRSELDQHGVTVALLLDADLPLVQADRVQVQQVIGNLILNAVDAMEAVPAADRRLSLLTRRDGQRVSLSVRDRGVGLPADHPERVFDAFWTTKSHGLGLGLSLSRSMIEANDGQIRAERPAGGGACFVFDLPVATEVPHA
>NZ_AP021867.1|WP_032970570.1|2444105_2444747_+|response-regulator-transcription-factor
MRKPAAPAADPAPIVYVIDDDPSVRAALEDLLASMGLQVRAFASTQAFLEHELEDAPACLVLDVRMPGQSGLEFHRTMGSHGLQLPVVFITGHGDIAMGVNAIKDGAIEFLTKPFRDQELLDAIHKGIDIDRQRRRDGEALDALQQRWNTLNAGEREVVDGVVRGRLNKQIAGDLGVSEITVKVRRAQVMRKMSARTLVDLVRMYDRLQAGTA
>NZ_AP021867.1|WP_153675762.1|2444743_2445289_+|DUF1697-domain-containing-protein
MSVHVALLRAVNVGGTGKLPMRELVAMCEDAGFTDVRTYIASGNVVFRSGLDEAGVRKALGQRLHAYAGKPVGVLVRSAAEIAAVAAGNPFPHAAGNRVVALFVDEALPTDPLTGVTGLRDEQLALGTREIFVHYGDGMADSRLRIPYAQQGTARNLNTVGKLAAMAAALGQVTSGGRGRR
>NZ_AP021867.1|WP_153675764.1|2445388_2446561_-|low-temperature-requirement-protein-A
MSTRLQLPALRQRDGHHARVTYEELFFDLVYVFAVTQLSHHLLHHLDLAGVLQTLVLWFAVWLGWQYACWVSNWFDPEAPRIRGLLFATMLLALLMSSSIPEAFADRAWVFAGAYATMQVGRTAFVLLEVGRTHPLAPNFRRMLAWVSVSACFWLAGAAAEGNTRLALWAVAVACEYVSPMFGFAFPGLGRSHTREWTIEGGHLAERCQLFVIVALGETLLATGGVLSEVEQWSGAVVSAVLATFAGTIAMWWLYFGISSRDATEAISHAEDPGRMGANFHYVHALLIAGIIATAVGNDLVMDHPHAAVTPVYAAVLVAGPLIYLLGSALYKRVVYGRAPYSHLIGAVALVVLGFVLLQTHLLAAGWLTSAVLLAVGLMDTRLKHRLQRA
>NZ_AP021867.1|WP_006369821.1|2446570_2446837_-|hypothetical-protein
MHVLLVMVGGIVLLGVFLLFGRLWSVGTSQLPTALIAFIATWLLVTVANLWVGVSKAGYGMREELPILLLVFAVPALLAGLLYWRLAR
>NZ_AP021867.1|WP_032970572.1|2447040_2447565_+|RNA-polymerase-sigma-factor
MSQPTLPRPPALPLVTSLVRHYEELVDYLHRRFRSPGLAREVVHDVCLRLLERPAVHDARQPIALLRRIAHDAAVDRCRAEDLRRHWVEPRAELPEGACERPGPERQAQGQQALQRLTTSIERMPCRRQQVFILHKIHELPQAEVAQRMGIGLKAVERHLRLAMADCRLHGALR
>NZ_AP021867.1|WP_153675766.1|2447561_2448413_+|FecR-domain-containing-protein
MSPASPDPAPPSAPAEPSAEDTLDQHREALKERFPLPGPEQLQRRRGGSGAKRVLPVLLLAVAALLLADPAWQVRDYQTAVGERRDIELPDGSRVLLDAGTHLQVRRHLRSRQVLLAQGHARFEVQHSAWRRFQVDAGPVQVRNYGTVFDVDRQGDLSEVTLWRGEVGVSVDGGGTEQRLKPGQRLLAQPGSLSPPEAVDPDRADWTTGRLQFDRMPLSEVLRILQRYHDRPIVLDDPALGPLQVSGVFDADRAETAVALLPEILPVQVQTAADGTLHLRARD
>NZ_AP021867.1|WP_153675768.1|2448484_2450914_+|TonB-dependent-receptor
MTRPVPPAALRRLAPTLLAACLCAALPATAQTAASAPVELHLPAGPLQTSLNSLARQSGIQLLFAADSVSGRNAPALDGRYTPHDALQRLLAGQGLAMQERSPGVFVVSATPASPKPRAPARAASSAASQATTTSLARVTVSASTARMPQGETAMPNTITVLTREDIAQQLALGSDVSRVLSAQIPAFAPAREKMSNYGETMRGRGILYMVDGVPQSTPLRDGSRDSHTIDPAMIERIEVIHGANALQGIGGTGGIVNIITRSAPSEPGAFLLDTNISYSSALPSRRDDNGQRGSALVGVRGEQFDLVAGLAYEKQGLYHDGEGRSIGTNAQGELMDSTSSNVFAKLGWNIAEGHHVQLMANRYELRGLDNYLAVNGDYRTGRPTISVPGDTPLEPPMNRSRSLTLDYSAADLLGGRFQAQAFAVDFEGRYGASQWDPWGNTGANAAWDQTQNESDKRGFKLTQSWARIADTTLDVTLGLDGLRDRTHQVLLASGMNWVPQTTYQSLSPLLQLHWWPTDHLMLSGGLRYEKGELEVGDYTTLPRYGARKVAGGKPTMSETLPNFGAVWYINDRLNAYASYSEGYTVADVGRVLRAINRDGQRVDSLIDLSPVVSDNREIGLEYDDGRFSGDIAYYTSESKLGSVLIYDPGIDAYAVQRQATRVEGFESNLRLRLGDSRLGLGYARANGRYDADVDGRLDSDLAGVNIAPNRLTAFWEQSWTPQLSTRLQASHAFDRDFDLRGAQVAEFKGYTTVDLVARYVLDKHSFTLGVQNLANKQYISYYSQTTPSNPSYFSGRGRVLTLGWQYRY
>NZ_AP021867.1|WP_153675770.1|2451009_2451882_+|L1-family-subclass-B3-metallo-beta-lactamase
MRFSLLAFALAAALPVAHARAAEAPLPQLRAYTVDASWLQPMAPLQIADHTWQIGTENLTALLVQTAEGAVLLDGGMPQMAGHLLDNMQARGVAPQDVRLILLSHAHADHAGPVAELKRRSGAHVVANAESAVLLARGGSDDLHFGDGITYPPANADRIVMDGEVVEVGGIEFTAHFMPGHTPGSTAWTWTDTREGKPVRIAYADSLSAPGYQLKGNLRYPRLVEDYKRSFATVRALPCDVLLTPHPGASNWDYAAGARAGAKALTCKAYADAAEQKFDAQLAKETAGAR
>NZ_AP021867.1|WP_153675771.1|2452022_2452562_-|DUF411-domain-containing-protein
MNRSLSLGLLLGTVLATTACARAAEESPAAPVVSQAPAAPIKASPSQVDPALPIAIVHKTASCGCCGIWVDHLKAEGFQVDVRNTDDMNPIKVRLGVPVGKASCHTAEIGGYVVEGHIPAEDIKRLLAERPAARGLVLPGMPAGSPGMEMPDGYVQPYTVELVRNDGTTEPFAQHGQGG

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Crispr_ID: NZ_AP021867_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP021867_10

2837142-2837241

Orphan

Consensus_repeat	Method
TGCCGACCAAGGTCGGCACCTACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP021867_10

>merge|NZ_AP021867|10|2837142-2837241|CRISPRCasFinder
TGCCGACCAAGGTCGGCACCTACCGGGTGATGTGAGCGTGCCGACCAAGGTCGGCACCTACCGGGTGATGTGAGCATGCCGACCAAGGTTGGCACCTACC

>NZ_AP021867|10|10|2837142-2837241|CRISPRCasFinder
TGCCGACCAAGGTCGGCACCTACC	GGGTGATGTGAGCGTGCCGACCAAGGTCGGCACCTACCGGGTGATGTGAGCA
TGCCGACCAAGGTTGGCACCTACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP021867.1\|WP_049460795.1\|2833893_2834244_+\|variant-SH3-domain-containing-protein	unknown	unknown	gnl\|CDD\|212778
NZ_AP021867.1\|WP_153675910.1\|2840002_2841088_-\|3-phosphoserine/phosphohydroxythreonine-transaminase	unknown	unknown	gnl\|CDD\|235428
NZ_AP021867.1\|WP_153675914.1\|2843298_2844309_+\|restriction-endonuclease	unknown	unknown	gnl\|CDD\|377369
NZ_AP021867.1\|WP_065724475.1\|2845223_2846594_-\|formimidoylglutamate-deiminase	unknown	unknown	gnl\|CDD\|236420
NZ_AP021867.1\|WP_153675902.1\|2830813_2831884_+\|DUF4241-domain-containing-protein	unknown	unknown	gnl\|CDD\|379427
NZ_AP021867.1\|WP_006376116.1\|2842570_2843062_+\|phasin-family-protein	unknown	unknown	gnl\|CDD\|377530
NZ_AP021867.1\|WP_006376049.1\|2835743_2836382_+\|energy-transducer-TonB	unknown	unknown	gnl\|CDD\|367555
NZ_AP021867.1\|WP_153675900.1\|2829983_2830535_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NZ_AP021867.1\|WP_153675908.1\|2838751_2839951_-\|prephenate-dehydratase	unknown	unknown	gnl\|CDD\|223155
NZ_AP021867.1\|WP_153675906.1\|2837367_2838675_-\|3-phosphoshikimate-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|237820
NZ_AP021867.1\|WP_153675904.1\|2836501_2837074_+\|TonB-family-protein	unknown	unknown	gnl\|CDD\|367555
NZ_AP021867.1\|WP_153676242.1\|2823512_2829119_-\|DUF3320-domain-containing-protein	unknown	unknown	gnl\|CDD\|380141
NZ_AP021867.1\|WP_006376047.1\|2834349_2835630_-\|serine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235461
NZ_AP021867.1\|WP_153675899.1\|2829255_2830026_+\|abortive-infection-family-protein	unknown	unknown	gnl\|CDD\|379577
NZ_AP021867.1\|WP_032129793.1\|2833080_2833668_+\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|234675
NZ_AP021867.1\|WP_006376127.1\|2846661_2847885_+\|imidazolonepropionase	unknown	unknown	gnl\|CDD\|236478
NZ_AP021867.1\|WP_006376114.1\|2842214_2842490_+\|polyhydroxyalkanoic-acid-system-family-protein	unknown	unknown	gnl\|CDD\|378230
NZ_AP021867.1\|WP_153675916.1\|2844466_2845195_-\|histidine-utilization-repressor	unknown	unknown	gnl\|CDD\|188194
NZ_AP021867.1\|WP_153675912.1\|2841282_2842089_-\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|224630
NZ_AP021867.1\|WP_005410175.1\|2831965_2832958_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176162

Protein	Function_ID	Function_description	E-value
NZ_AP021867.1\|WP_049460795.1\|2833893_2834244_+\|variant-SH3-domain-containing-protein	gnl\|CDD\|212778	cd11844, SH3_CAS, Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding proteins. CAS proteins function as molecular scaffolds to regulate protein complexes that are involved in many cellular processes including migration, chemotaxis, apoptosis, differentiation, and progenitor cell function. They mediate the signaling of integrins at focal adhesions where they localize, and thus, regulate cell invasion and survival. Over-expression of these proteins is implicated in poor prognosis, increased metastasis, and resistance to chemotherapeutics in many cancers such as breast, lung, melanoma, and glioblastoma. CAS proteins have also been linked to the pathogenesis of inflammatory disorders, Alzheimer's, Parkinson's, and developmental defects. They share a common domain structure that includes an N-terminal SH3 domain, an unstructured substrate domain that contains many YxxP motifs, a serine-rich four-helix bundle, and a FAT-like C-terminal domain. Vertebrates contain four CAS proteins: BCAR1 (or p130Cas), NEDD9 (or HEF1), EFS (or SIN), and CASS4 (or HEPL). The SH3 domain of CAS proteins binds to diverse partners including FAK, FRNK, Pyk2, PTP-PEST, DOCK180, among others. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.	0.00177295
NZ_AP021867.1\|WP_153675910.1\|2840002_2841088_-\|3-phosphoserine/phosphohydroxythreonine-transaminase	gnl\|CDD\|235428	PRK05355, PRK05355, 3-phosphoserine/phosphohydroxythreonine transaminase.	0
NZ_AP021867.1\|WP_153675914.1\|2843298_2844309_+\|restriction-endonuclease	gnl\|CDD\|377369	pfam04471, Mrr_cat, Restriction endonuclease. Prokaryotic family found in type II restriction enzymes containing the hallmark (D/E)-(D/E)XK active site. Presence of catalytic residues implicates this region in the enzymatic cleavage of DNA.	1.31907e-07
NZ_AP021867.1\|WP_065724475.1\|2845223_2846594_-\|formimidoylglutamate-deiminase	gnl\|CDD\|236420	PRK09229, PRK09229, N-formimino-L-glutamate deiminase; Validated.	0
NZ_AP021867.1\|WP_153675902.1\|2830813_2831884_+\|DUF4241-domain-containing-protein	gnl\|CDD\|379427	pfam14025, DUF4241, Protein of unknown function (DUF4241). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 205 and 315 amino acids in length. There is a conserved GDG sequence motif at the C-terminus.	5.84459e-39
NZ_AP021867.1\|WP_006376116.1\|2842570_2843062_+\|phasin-family-protein	gnl\|CDD\|377530	pfam05597, Phasin, Poly(hydroxyalcanoate) granule associated protein (phasin). Polyhydroxyalkanoates (PHAs) are storage polyesters synthesized by various bacteria as intracellular carbon and energy reserve material. PHAs are accumulated as water-insoluble inclusions within the cells. This family consists of the phasins PhaF and PhaI which act as a transcriptional regulator of PHA biosynthesis genes. PhaF has been proposed to repress expression of the phaC1 gene and the phaIF operon.	4.74072e-41
NZ_AP021867.1\|WP_006376049.1\|2835743_2836382_+\|energy-transducer-TonB	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	5.93792e-25
NZ_AP021867.1\|WP_153675900.1\|2829983_2830535_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.98309e-05
NZ_AP021867.1\|WP_153675908.1\|2838751_2839951_-\|prephenate-dehydratase	gnl\|CDD\|223155	COG0077, PheA, Prephenate dehydratase [Amino acid transport and metabolism].	6.7383e-120
NZ_AP021867.1\|WP_153675906.1\|2837367_2838675_-\|3-phosphoshikimate-1-carboxyvinyltransferase	gnl\|CDD\|237820	PRK14806, PRK14806, bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional.	0
NZ_AP021867.1\|WP_153675904.1\|2836501_2837074_+\|TonB-family-protein	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	6.8392e-21
NZ_AP021867.1\|WP_153676242.1\|2823512_2829119_-\|DUF3320-domain-containing-protein	gnl\|CDD\|380141	pfam18741, MTES_1575, REase_MTES_1575. Vsr REase Fold. Fused to HEPN (SWT1/Abi2 family), along with Transglutaminase and wHTH.	6.01859e-38
NZ_AP021867.1\|WP_006376047.1\|2834349_2835630_-\|serine--tRNA-ligase	gnl\|CDD\|235461	PRK05431, PRK05431, seryl-tRNA synthetase; Provisional.	0
NZ_AP021867.1\|WP_153675899.1\|2829255_2830026_+\|abortive-infection-family-protein	gnl\|CDD\|379577	pfam14355, Abi_C, Abortive infection C-terminus. This domain is found at the C-terminus of the Lactococcus lactis abortive infection protein Abi-859. This protein confers bacteriophage resistance.	6.13481e-08
NZ_AP021867.1\|WP_032129793.1\|2833080_2833668_+\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|234675	PRK00170, PRK00170, azoreductase; Reviewed.	5.28457e-79
NZ_AP021867.1\|WP_006376127.1\|2846661_2847885_+\|imidazolonepropionase	gnl\|CDD\|236478	PRK09356, PRK09356, imidazolonepropionase; Validated.	0
NZ_AP021867.1\|WP_006376114.1\|2842214_2842490_+\|polyhydroxyalkanoic-acid-system-family-protein	gnl\|CDD\|378230	pfam09650, PHA_gran_rgn, Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn). Proteins in this entry are encoded by genes involved in either polyhydroxyalkanoic acid (PHA) biosynthesis or utilisation, including proteins found at the surface of PHA granules. These proteins have so far been found in the Pseudomonadales, Xanthomonadales, and Vibrionales, all of which belong to the Gammaproteobacteria.	3.79667e-33
NZ_AP021867.1\|WP_153675916.1\|2844466_2845195_-\|histidine-utilization-repressor	gnl\|CDD\|188194	TIGR02018, Histidine_utilization_repressor, histidine utilization repressor, proteobacterial. This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions].	5.77789e-95
NZ_AP021867.1\|WP_153675912.1\|2841282_2842089_-\|FHA-domain-containing-protein	gnl\|CDD\|224630	COG1716, COG1716, FOG: FHA domain [Signal transduction mechanisms].	5.78378e-14
NZ_AP021867.1\|WP_005410175.1\|2831965_2832958_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176162	cd08473, PBP2_CrgA_like_4, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 4. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.42339e-98

>NZ_AP021867.1|WP_153675904.1|2836501_2837074_+|TonB-family-protein
MTATTHENLHSPHLPQDSSAQHTPTSPWMWIALIVAMFAAALLWLRHSNQEDVAPAPVGERMLPAPEQAAMTDAATPATRQAAPASSQRKAAPAIRNREARPLASNRMPTYPAAALRSGVQGSVIASLNVDTRGNVANAAIVSRSGERSRDLDRAVLNTVQNWKFQPAMHEGRAVASVVRVPVDFRTEQR
>NZ_AP021867.1|WP_006376049.1|2835743_2836382_+|energy-transducer-TonB
MSAPRSSSAKSFTVHIPRNALKIAGIAFGVGVLLFVLVWLTGRDKEFFRADPAAQTPQETAQVEPLPEPLAAAAGSSDMPDAKPAPVEEEAPKLVETAPPPPAPIAEPSPAAPSAAPAATGNSQPMPIAGQSPPPSYPAAALRAGETGTVVVRVDVDATGYPNNTTLIQRSGSRELDRAATDAVRRWRFTPAQSNGQAVPGSIEVPFDFKTQ
>NZ_AP021867.1|WP_006376047.1|2834349_2835630_-|serine--tRNA-ligase
MLDPALLRHQPADLAERLRTSRGFELDVSALESLEADRKRIQVRTQELQSLRNSRSKAIGQAKAKGEDVSAIMAEVAAFADELKASEVALDELREKIDAISMGIPNLPADDVPAGADENDNVEQARWGTARQFDFKVLDHVELGARNGWLDGETAAKLSGSRFTVLRGPIARLHRALAQFMVDLHTGEHGYEETNVPLLVNADSLRGTSQLPKFEDDLFKTAVGDSTRYLIPTSEVPLTNIVRDEIVDAERLPLRMTAHSMCFRAEAGSGGRDVRGMIRQHQFEKVELVSISRPEDSDAEHQRMTRCAEVVLEKLGLPYRKVLLCTGDMGFSAVKTYDLEVWLPSQETYREISSCSNCGDFQARRMQARWRNPATGKPELAHTLNGSGVAVGRAMIAVMENYQNADGSITVPEALRPYMGGLETIG
>NZ_AP021867.1|WP_049460795.1|2833893_2834244_+|variant-SH3-domain-containing-protein
MNYIVTTAHRSEFPHPITLRRGQALVVGERYEGPEGWEDWFLCEAEGQQPGFVPAPVIGRDAQGGAFATEDYCARELDVDPGQLLRGERTLNGWAWCVPETGEPGWVPLEKVRVVE
>NZ_AP021867.1|WP_032129793.1|2833080_2833668_+|NAD(P)H-dependent-oxidoreductase
MKLLHIDASVLGDNSVSRHLTAAVVAQFTQQIDGLQVDYRDLDANPVPHLRSGSLAKADAAEAADAEQVLEQFLAADIVVIGAPMYNFSIPSTLKAWIDRVAVAGRTFKYTENGPVGLAGGKRVIIASSRGGIYTDSPADFQEPFLRQTFAFWGINDVEFVRAEGIAYSPQHREDAIAGALAALPSHEAAEAAAA
>NZ_AP021867.1|WP_005410175.1|2831965_2832958_-|LysR-family-transcriptional-regulator
MHDLNDLYYFAMVVDHGGFAAAERALGIPKSRLSRRISQLETDLGVRLLQRSTRRFAVTDVGTSVHRHAQTMLAEAQAAREVVDRLSAEPRGVVRASVPVSLAQMQLPKLLPKFLEQYPKVRLQLNISNRRVDIINEGYDVALRVRSRLDDDGSLVMRSFGQVQELLVASPKYLDRAGRPKDPEELTQHVTLSISEDEARQRWELHGPEGEVRRVDLQPRVAGFDFPLLQSMVKDGFGITMLPETVCADAVRNGELEVVLPDWSLPQGVCHAVFASRRGLLPAVRVFIDFLAEHLPPQLEASRLDCGGACEKAKERIKASALGALAVDAG
>NZ_AP021867.1|WP_153675902.1|2830813_2831884_+|DUF4241-domain-containing-protein
MAHLDLANLRTTLLGDTQLAAVALHRTFAGHLPVSSGHLVVCDPLVQAEAPALADYTAPLGRHPVEIIVHSGRPALAVVWFKPREALTASALHWQMARWTTQDLTGLDEDSFIGYPVDAGIGCFMDTNTQQALLALIEQTDGDEDSEWSDALIDHDGLDEGAEYRPWGEDSPHGLVVFTSGWGDGVYPSYWALDTSGIPVALVTDFLCIQGGDGRDEREIADQAYRDSLPPEEAEALARLVAAVDRDDPDALRELLKDAPQRANQIEPGCGGTALFEAIRLDRPQALRVLLQGGALPAMPERLHMSKVTSYMDYARLLKKPRSAELMAVLEAPVVAEPAPATPPRRSFWDRLFGRK
>NZ_AP021867.1|WP_153675900.1|2829983_2830535_-|helix-turn-helix-domain-containing-protein
MQRKHSHAHSHHFSLSSTGRWLFVQRVPVDLQAVPDCRLIKRTLRTRYLAQAQAAAGAVLGLVKESTAAPGISRYERGDRMPDNESVAKLAETLELPVAYFHAVSEPMVETILVMAQLPEEAQEEQVHRMREFAKGECANRGGATGVDLAICRPGFSKSDHWPWATRLQFYALRSAPLLLSRY
>NZ_AP021867.1|WP_153675899.1|2829255_2830026_+|abortive-infection-family-protein
MEGLRPTEIHWIISHYIGVSGGYLGDFTYPSHREFYAAYCDLTVDPEDYPGTTRQRFLAVLSSADPQTQAAIVRGVARRFPVGSEVQRTQDARSKLLAMAKRCSQVASVEPTSPRLASELVRQALADAASLLEMQGPVSALDRVHTALHGYLKTVCRSAGLDMAALPADPGVTQIFKLMRENHPALRDMGVQDDAMRKIVFSIGNILDSLNPLRNRGSLAHANDHLVERDEALLAINLTRSIIQYLDSKSGADRNA
>NZ_AP021867.1|WP_153676242.1|2823512_2829119_-|DUF3320-domain-containing-protein
MLRERGSLIDKVNRARLELLDLSTRNRLLSVPRSGHAKTVEVVNELAQAMYQTLVIDGKRFTFVAGRADPKTAVDDTVGEGDDQSDLASAVQVKGFDAESDLATIQDEPDDLELLAQPSLELDEQGRRVSHWDAQLMTRLTPTGLQKRLLDLYVDARTLQEEQGINVLYLGIGYLKWRAPTTPKIDRYAPLVLVPVALERSNAGEKFHLRWQGDEIVANLSLQLFLQRQFEMKLPEIDEFESLEIDDYLSKVASLIEGKPDWAVVPDDAVLGLFSFAKFMMYRDLDPVSWEQSGGLEALPALRGVVSDGFPGAVVSTNEEDIDATVSPELMRHVVDSDSSQSLVVHDVLKGRNIVVQGPPGTGKSQTIANIIAGAIADKKRVLFVAEKLAALEVVKRRLDQVRLGVACLELHSNKANKRALLEELRLTWNLSPLADEDSGPIVRQLTERRDLLNAHASRLHQEMLPSRLTPYEVFGNLVRLRREGHVTARIRLDSPLEWAWDRVEENQKLLQDLCDRVLTMGIPDQHAWAGVGNDALLPNDRDRLIRDIAELANTLEDWKQRTVELTSVLDLTFSDSLDAPQAAIYRTKILLTAPPLGADALADASWETPADPESLIEDVRRAQELRRTCNEFAADSAIEHVWEQTRQELSRVPSDFVLGRELSVMRDAHQKLSGMGSDLARLAQLVGEQRPLTFEVMAHVCALAERASSAPQIDRDALVARIWERGVDSVQNLVDWVQQVQAARRELSEVFRESAWSANLEGARLQIASRAGSFFRFLSGEWRAANRLVRAQLRNPKLPADQLLPALDKLLDAQAALRRVDEGNAQGEEAFGANWERDRSDTAFLRSVVAWMRGMRPLGLGAREQVAAIGDKGLAAELAARLGPGLAELQALLSPIHESLLTSGQMLWSVAESSLPRVPLLRLFDDTASFGQAISVCDSLNDSRSMTVSLALERIDALTTAQAAIAQLAQSDRQGKVAFGDLWRGLASDAAALQDACLWMTTNAGLRMLASRTADPQQKLERATNQLEEAERLGIELSELFTALRFAGNDEVASNTADVSVNATIGQLKAWEADPEGLPQWVAYIAQANAAKRRGLKNFADALATGVLAPDEARGTFDLAYYEAVLSAMVARAPELATFDGKRQTELVESFCELDRSRIDLARRQVSRSHRERIPSKNGAAGPVAVILGEMAKKRSHLPIRQLMVSAAPAIQALKPVFMMSPLSVAQFLPPGAVEFDILVIDEASQVQPIDALGAIARAKQLVIVGDERQLPPTRFFSRALGDSTTPSDDSAAPADVESILGLCLARGLPDRMLQWHYRSRHQSLIAVSNSQFYENKLLIVPSPYTSEAGVGLRFHHLPDAVYDRGGTSTNAREAKAVAMAVIAHAQTTPHLTLGAAAFSTQQRRAIFDEVELLRRQHPETEGFFTAHAHEPFFVKSLENIQGDERDVIFISIGYGRDSRGGVSMNFGPVSSEGGERRLNVLISRAKQRCEVFSSITDDDIDLSRGKGKGTAALKLFLHYARTGRLQIAGEAVEERKKTFEQEVAKALIARGYDLHMHVGVAGFFVDIAIADPDRPGRYIIGIECDGDSYRRSNGARDRDRLRDQALRDKGWQVHRVWSAEWFLRPVAELDALVRVIERSKLEPDPFEAEAVSRSRAVPVNFESVDHDDFVEVGLVSSDELPNTDPYVEANFSVPSQQQELHAVPAMRMAGFVRDVVHVEGPIHRSEVVVRIRSLWGLQRAGGRIQSAVDEGIRRAVEDGLVLQDGEFLLWPGRAIRVRDRSSVHSLSLRRPELLPSMEMDAAILELVRENLGASLDEVALHVSRRLGFRTTSAQLRAALVGRAEILLARGVLDLRNGLLVERPVQQ
>NZ_AP021867.1|WP_153675906.1|2837367_2838675_-|3-phosphoshikimate-1-carboxyvinyltransferase
MSNAQHWIARKGQPLQGSLTIPGDKSVSHRSVMFAALADGTSHIEGFLEGEDTRATARIFSQLGVRIETPSASQRIVHGVGIDGLKAPDAPLDCGNAGTGMRLLAGLLAGQSFDCTLIGDESLSGRPMRRVTGPLSQMGAKIDTQDDGTPPLHVHGGQSLHGIDFASPVASAQIKSAVLLAGLYAQGETSVVEPHPTRDYTERMLSAFGVEIEFSPGKARLRGGQRLRATDIVVPADFSSAAFYLVAASIIPGSELRLKQVGLNPRRTGLLHALRLMGADITEENPAEQGGEPVADLVVRYAPLKGARIPEELVPDMIDEFPALFVAAAAAEGQTVVSGAAELRVKESDRLAAMATGLRALGMQVDETEDGATLHGGVRLGSGIIESHGDHRIAMAFAIAGQISDGEVRINDIANVATSFPDFDGLARGAGFNLA
>NZ_AP021867.1|WP_153675908.1|2838751_2839951_-|prephenate-dehydratase
MASSKSSKKAPKKAEPAKDSASTKAKGKAKAASNPAPTLAPLALADVRSKIDQIDRDIQNLIAERARFAHQVGKAKGKLAAAVDYYRPEREAQVLRMVVDRNEGPLSDELLVHVYREIMSACLAQQEPLKIGYLGPEGTFSQQAVLKHFGRSALGLPMASIEEVFQEVEAGNADFGVVPVENSGQGTIQITLDMFLTSNLKICGEVELRVQQYLMSRSGRIEDIERIYAHPQSFMQTSAWLRANLPKAEKIPVSSNAEGARRARNADDAAAIGGESAGHVYGLKKVVTKPIQNDADNTTRFLVVGRNIFPTSGHDRTSVLVFIHDKPGALFDVLSPFARHGISMNRIESRPSHHGKWEYGFFIDLAGHIDDAPMQAALAELEAHSAQIKVLGSYPVAVP
>NZ_AP021867.1|WP_153675910.1|2840002_2841088_-|3-phosphoserine/phosphohydroxythreonine-transaminase
MTRAFNFSAGPATLPESVLRQAQAEMLDWHGSGASIVEMSHRGAEFMSVAAEAEADLRRLLDIPEDYAVLFLSGGATTQQALIPLNFAAPGQRADYVVSGHWGKTAVKQAGVYVDVNIAASSEAGGYRTLPPRADWQLSPDAAYVHITANETIHGVEFRDVPDTGNVPLIADFSSSIASEPLDVRRYGVIYAGAQKNLGPVGIAVMIIRLDLLERSGQPRADIFDYRSHVARDSMLNTPPTWNWYLAGLVFKWMLAEGGVAEFAKRNAAKAALVYGAIDGSGGFYRNEVAHAARSRMNIPFFLPDAELDARFVAEAKAAGLLALKGHKVVGGIRASLYNAMPVAGAEALVAFMADFQQRHG
>NZ_AP021867.1|WP_153675912.1|2841282_2842089_-|FHA-domain-containing-protein
MQNLLVHFSQQQQPDQPLRPGVQRIVRQANGSVRLGDAGNGALLLAQFCMDDRGLWLQVGNGIRGIHVNGRPVRRMALLRAGDAVYVDGVEMVLQGEVESLLQAPAPSSDDGNNEQQRLLRGVGGLHHGRSFTLSRTRLVGRGSDADIEINEPAFAEQHARVEVHGERVLLRDLGSADGTRVNGVAVRHCWLQAGDQVVFDGQHRFVLEVPHDPRRRPLPDEDESSQDIEQAPVLPAAPRKVRRWPWLLVSALLLAAVLSLLLWFGAR
>NZ_AP021867.1|WP_006376114.1|2842214_2842490_+|polyhydroxyalkanoic-acid-system-family-protein
MSNIDVRHAHALPDAQARAAIEQVAAKLSERFGLKSSWSADVLNFSGSGVDGAIELQPGAVRVTAKLGFLLSAMKGMVEGEIQRVLKEKLG
>NZ_AP021867.1|WP_006376116.1|2842570_2843062_+|phasin-family-protein
MNRYENDDRRDDDASFGDQAERFSRRLSDSAQQVWLAGLGALGRAQAEGGRFFDGLVKEGEAWEARRRERNGEQPPGWRDNVESSLDEAREKASGTWTKVEKAFDDQVQGVLKRLHVPTADEVTALEARIDALQARLAKLENRAASDIDAPAPGSHQSPGSVP
>NZ_AP021867.1|WP_153675914.1|2843298_2844309_+|restriction-endonuclease
MLPWILALLSALLTCSLAVVYLWWIKRRQKEMQLGLQALAGMHWREFSVLVKRMLREQRGLRELNDPTEESREPSSDFLLSDGPNSWLVSCKHGLAYRIGTAAVNELGAAARLAGARGGVLLTEGRMERDGRSAAEKQAVEVLDGPRLWPLLQPYLPVDIEARVRASARHEALRRIAIAALGSVTLGLLMGLSLQGLHVQETTAAAQVPAVPAPVASAPMIEPAPEPAANAAPPAGASSPAAPAADARSNPNPDAATLDRFQVELARALAGKPGIASGVWLTRQTLAINRTGELEAVWPRVCEEVLHYPALRNVRIQLNARPGVDEPVRWRQCATY
>NZ_AP021867.1|WP_153675916.1|2844466_2845195_-|histidine-utilization-repressor
MKASKSATLNQRIRSDLESRILSGEWAPGFRIPYEHELMEQYGCSRMTVNKVLTALAESGMIERRRRAGSFVARQPPHLEQVALEIPDIAMEVGSRGHQYGYHLLQRELRLADAGNVGEVELAGSEQLLAMRCLHLADGRPLALEHRLISPVGVPEVLDVDFNITAPGSWLLQNVSWTRAQHRISAWGADTATAKLLDVKPGTACLVIERLTWRGEQPITRVRQVFLGDAWDLVARFAPGAR
>NZ_AP021867.1|WP_065724475.1|2845223_2846594_-|formimidoylglutamate-deiminase
MSDSRSPHSFHAAHALLADGWARDVRLQVQDGRITAIHTGQGAQDGDTRVGILVPGLPNLHSHAFQRGMAGLTEIGGGDGDSFWSWRELMYRFLAHLRPDAVQAIAAQAYMEMLESGFTRVGEFHYLHHDADGRPYANRAEMSARIAAAADQTGIGLTLLPVFYAHADFGGAAPNPAQRRLIHDVEGFAQLLDAAKPSLAALPDAVLGIAPHSLRAVTGEELSALLPLTDGPVHIHIAEQVREVEACLAWSGQRPVQWLYDHAPVDARWCLVHATHITDDERASIVASQAVAGLCPITEANLGDGLFPMQAFAREGGRFGVGSDSNVLIDAAEELRLLEYGQRLTLRGRNVLAPDATRSSGRFLFEGALQGGAQALGVAAGLQVGASADLVELDAAHPALQARQDDAWLDSWVFAARNGALRSVWRHGRQCVAEGRHLQREAITTAFAAALRGVLG
>NZ_AP021867.1|WP_006376127.1|2846661_2847885_+|imidazolonepropionase
MHVDTLWSNVHLITLDGEGLGVIRDGVLACADGRIVHVGPAGSDAHLQPTTRIDGEGRWMSPGLIDCHTHLVYAGNRANEFEQRLQGISYAEIARAGGGIVSTVRATRAATPEQLASESRPRLLAMRAEGVTTLEIKSGYGLTLPDERKQLQVARALGEGCRVNVVTTFLGAHAIPPGREAQEYTDEVCNVMIPAIAAEGLAEAVDVFCENIAFSPAQARQVFEAARAHGLAIKIHAEQLSNQHGAELAASFGALSADHIEHLDDAGIAAMAAAGTVAVLLPGAFYFTRDTTLPPIAALRAAGVPLALATDSNPGTSPLTSPLLAMNMGATLFRLTVDECIAGFTREAARALGRGDRIGRLAIGMDCDLAIWDIDAPADLVYRIGFNPLHARVVRGQPDLPASWSNT

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Crispr_ID: NZ_AP021867_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP021867_11

3638526-3638671

Orphan

Consensus_repeat	Method
GCCAACCTTGGTTGGCGCCCCGTGCCGACCAAGGTCGGCACCTACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP021867_11

>merge|NZ_AP021867|11|3638526-3638671|CRISPRCasFinder
GCCAACCTTGGTTGGCGCCCCGTGCCGACCAAGGTCGGCACCTACCGAAGCGTTGGTGGGTGCCAACCGTGGGTTGGCATCGATGCTGCCCCTGGTAGCCGCCAACCTTGGTTGGCGCCTCGTGCCGACCAAGGTCGGCACCTACC

>NZ_AP021867|11|11|3638526-3638671|CRISPRCasFinder
GCCAACCTTGGTTGGCGCCCCGTGCCGACCAAGGTCGGCACCTACC	GAAGCGTTGGTGGGTGCCAACCGTGGGTTGGCATCGATGCTGCCCCTGGTAGCC
GCCAACCTTGGTTGGCGCCTCGTGCCGACCAAGGTCGGCACCTACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP021867.1\|WP_100469430.1\|3627117_3628122_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238744
NZ_AP021867.1\|WP_012511972.1\|3628118_3628568_-\|DUF4381-family-protein	unknown	unknown	gnl\|CDD\|379552
NZ_AP021867.1\|WP_153676073.1\|3640560_3646005_-\|YadA-like-family-protein	unknown	unknown	gnl\|CDD\|240612
NZ_AP021867.1\|WP_100469460.1\|3652683_3653457_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380379
NZ_AP021867.1\|WP_153676072.1\|3636046_3638470_+\|PBP1A-family-penicillin-binding-protein	unknown	unknown	gnl\|CDD\|227342
NZ_AP021867.1\|WP_100469454.1\|3650734_3651235_-\|fimbrial-protein	unknown	unknown	gnl\|CDD\|367947
NZ_AP021867.1\|WP_041864582.1\|3629502_3630528_-\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NZ_AP021867.1\|WP_012511988.1\|3653606_3654884_-\|citrate-synthase	unknown	unknown	gnl\|CDD\|180164
NZ_AP021867.1\|WP_006388913.1\|3633243_3633900_-\|type-4a-pilus-biogenesis-protein-PilO	unknown	unknown	gnl\|CDD\|225708
NZ_AP021867.1\|WP_012511978.1\|3638815_3639460_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_174238308.1\|3634768_3635851_-\|pilus-assembly-protein-PilM	unknown	unknown	gnl\|CDD\|378558
NZ_AP021867.1\|WP_100469457.1\|3651831_3652590_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_AP021867.1\|WP_012511976.1\|3633896_3634769_-\|PilN-domain-containing-protein	unknown	unknown	gnl\|CDD\|225707
NZ_AP021867.1\|WP_065723814.1\|3628564_3629494_-\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NZ_AP021867.1\|WP_100469451.1\|3647940_3650673_-\|TcfC-E-set-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|185210
NZ_AP021867.1\|WP_100469448.1\|3646066_3646774_-\|pilus-assembly-protein	unknown	unknown	gnl\|CDD\|237939
NZ_AP021867.1\|WP_006388908.1\|3630718_3632692_-\|type-IV-pilus-secretin-PilQ-family-protein	unknown	unknown	gnl\|CDD\|274173
NZ_AP021867.1\|WP_012511982.1\|3646792_3647944_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|284778
NZ_AP021867.1\|WP_100469442.1\|3639741_3640491_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_050559910.1\|3632713_3633217_-\|pilus-assembly-protein-PilP	unknown	unknown	gnl\|CDD\|377322

Protein	Function_ID	Function_description	E-value
NZ_AP021867.1\|WP_100469430.1\|3627117_3628122_-\|VWA-domain-containing-protein	gnl\|CDD\|238744	cd01467, vWA_BatA_type, VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses. In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Members of this subgroup are bacterial in origin. They are typified by the presence of a MIDAS motif.	1.51302e-76
NZ_AP021867.1\|WP_012511972.1\|3628118_3628568_-\|DUF4381-family-protein	gnl\|CDD\|379552	pfam14316, DUF4381, Domain of unknown function (DUF4381). This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 158 and 180 amino acids in length.	6.70611e-22
NZ_AP021867.1\|WP_153676073.1\|3640560_3646005_-\|YadA-like-family-protein	gnl\|CDD\|240612	cd12820, LbR_YadA-like, YadA-like, left-handed beta-roll. This group contains the collagen-binding domain virulence factor YadA an adhesion proteins of several Yersinia species, and related cell surface proteins, including Moraxella catarrhalis UspA-like proteins. The collagen-binding portion is found in the hydrophobic N-terminal region. YadA forms a matrix on the bacterial outer membrane, which mediates binding to collagen and epithelial cells. YadA inhibits the complement-activating pathway with the coating of the cell surface with factor H, which impedes C3b molecules. These domains form a left handed beta roll made up of a series of short repeated elements. UspA1 and UspA2 are part of a class of pathogenicity factors that act as cell surface adhesion molecules, in which N-terminal head and neck domains extend from the bacterial outer membrane. The UspA1 head domain of Moraxella catarrhalis, is formed from trimeric left-handed parallel beta-helices of 14-16 amino acid repeats. The UspA1 head domain connects to a neck region of large extended, charged loops that maybe be ligand binding, which is in turn connected to an extended coiled coil domain that tethers the head and neck region to the cell surface via a transmembrane region.	2.20238e-19
NZ_AP021867.1\|WP_100469460.1\|3652683_3653457_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|380379	cd06124, cupin_NimR-like_N, AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain. This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	5.27344e-33
NZ_AP021867.1\|WP_153676072.1\|3636046_3638470_+\|PBP1A-family-penicillin-binding-protein	gnl\|CDD\|227342	COG5009, MrcA, Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane].	0
NZ_AP021867.1\|WP_100469454.1\|3650734_3651235_-\|fimbrial-protein	gnl\|CDD\|367947	pfam04449, Fimbrial_CS1, CS1 type fimbrial major subunit. Fimbriae, also known as pili, form filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometres. They enable the cell to colonise host epithelia. This family constitutes the major subunits of CS1 like pili, including CS2 and CFA1 from Escherichia coli, and also the Cable type II pilin major subunit from Burkholderia cepacia. The major subunit of CS1 pili is called CooA. Periplasmic CooA is mostly complexed with the assembly protein CooB. In addition, a small pool of CooA multimers, and CooA-CooD complexes exists, but the functional significance is unknown. A member of this family has also been identified in Salmonella typhi and Salmonella enterica.	1.16583e-24
NZ_AP021867.1\|WP_041864582.1\|3629502_3630528_-\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	3.10539e-91
NZ_AP021867.1\|WP_012511988.1\|3653606_3654884_-\|citrate-synthase	gnl\|CDD\|180164	PRK05614, gltA, citrate synthase.	0
NZ_AP021867.1\|WP_006388913.1\|3633243_3633900_-\|type-4a-pilus-biogenesis-protein-PilO	gnl\|CDD\|225708	COG3167, PilO, Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion].	3.0997e-76
NZ_AP021867.1\|WP_174238308.1\|3634768_3635851_-\|pilus-assembly-protein-PilM	gnl\|CDD\|378558	pfam11104, PilM_2, Type IV pilus assembly protein PilM;. The type IV pilus assembly protein PilM is required for competency and pilus biogenesis. It binds to PilN and ATP.	2.50839e-170
NZ_AP021867.1\|WP_100469457.1\|3651831_3652590_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.31678e-22
NZ_AP021867.1\|WP_012511976.1\|3633896_3634769_-\|PilN-domain-containing-protein	gnl\|CDD\|225707	COG3166, PilN, Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion].	9.64979e-52
NZ_AP021867.1\|WP_065723814.1\|3628564_3629494_-\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	1.00143e-23
NZ_AP021867.1\|WP_100469451.1\|3647940_3650673_-\|TcfC-E-set-like-domain-containing-protein	gnl\|CDD\|185210	PRK15310, PRK15310, fimbrial outer membrane usher protein TcfC; Provisional.	1.02726e-180
NZ_AP021867.1\|WP_100469448.1\|3646066_3646774_-\|pilus-assembly-protein	gnl\|CDD\|237939	PRK15308, PRK15308, fimbrial protein TcfA.	5.8297e-45
NZ_AP021867.1\|WP_006388908.1\|3630718_3632692_-\|type-IV-pilus-secretin-PilQ-family-protein	gnl\|CDD\|274173	TIGR02515, Putative_DNA_transport_protein_HofQ, type IV pilus secretin (or competence protein) PilQ. A number of proteins homologous to PilQ are involved in type IV pilus formation, competence for transformation, type III secretion, and type II secretion (also called the main terminal branch of the general secretion pathway). Members of this family include PilQ itself, which is a component of the type IV pilus structure, from a number of species. In Haemophilus influenzae, the member of this family is associated with competence for transformation with exogenous DNA rather than with formation of a type IV pilus; the surface structure required for competence may be considered an unusual, incomplete type IV pilus structure. [Cell envelope, Surface structures].	0
NZ_AP021867.1\|WP_012511982.1\|3646792_3647944_-\|hypothetical-protein	gnl\|CDD\|284778	pfam07434, CblD, CblD like pilus biogenesis initiator. This family consists of several minor pilin proteins including CblD from Burkholderia cepacia which is known to CblD be the initiator of pilus biogenesis. The family also contains a variety of Enterobacterial minor pilin proteins.	1.31231e-44
NZ_AP021867.1\|WP_050559910.1\|3632713_3633217_-\|pilus-assembly-protein-PilP	gnl\|CDD\|377322	pfam04351, PilP, Pilus assembly protein, PilP. The PilP family are periplasmic proteins involved in the biogenesis of type IV pili.	9.68938e-65

>NZ_AP021867.1|WP_153676072.1|3636046_3638470_+|PBP1A-family-penicillin-binding-protein
MTRLRRWLRWIFLIVLVLALIGAAAVGGLYYAVSSKLPDVQTLRDVEMQEPMYVYAADGKLMAVFGETRRTPITMKDVPERLKQAFLATEDARFYEHGGVDYMGIGRAVWLLATTSDKRVPGGSTITQQVARQFFLSSEYSYTRKLAEILLARKIESELSKDEIFELYLNKSFFGNRAYGVAAAAEFYYGKKLNELDLDEMASLAGIPKFPSSGNPISNPERARQRRDNYVLQRMADLKFVSQAEADAAKAVPMHATAHEPPVQVDAPYVAELVRQEMIARFGGDVVNKGYHVTTTIDATLQTAANQSVRDGLLLYDHRHGWHGVEKQVQVGAGEDAAALAEHLRGMFGQAGLLPAIVASTGADGSATVVLANRSEIVLPAGAAKWTNKTPGKLVQRGDIVRVRTGAKEGEWLLDQLPRGQSALVSLDAHSGALKALVGGFSFSGNKFNRATQARRQPGSSFKPFVYAAAFDKGYNPASIVLDAPVVFRDRRGKTWAPQNDGGGFRGPMRLREALVQSRNLVSVRLLDGMGVDYARKYISEFGFAESELPPNLSMSLGTASLTPLSVARGYAVFANGGSRVDTWLIDQVNDRDGNLVFKENPAMACRDCAGSSGQPVNQVVDGFNFGAPAPKVDPAAAATAEAKTETPAAPANPDARTAPRAIDARTAYQLVSMMRDVVQRGTGAQAKVLGREDVGGKTGSTNDHRDAWFSGFGGPYVTTVWVGRDDFRSLGYREYGGKAALPIWIDYMRTALKDTPIAQNEPPSGMVQATLNGATEWVKVEDMDRLTDYDLNLNTPQADAAAFDIF
>NZ_AP021867.1|WP_174238308.1|3634768_3635851_-|pilus-assembly-protein-PilM
MPVGRGETVGLIPKSQSPLVGVDISSTAVKLLQLSRSGNRFRVEHYAVEPLPPNAVVEKNIVEVEAVGEAIRRAMNRSGSKAKLAAAAVAGSAVITKVIPMPAELDENDMEAQIELEAVNYIPYPIEEVNLDFEVIGAIPNNPEMVQVLLAASRSENVELRQSALELGGLQAKVMDVEAFAVENAYALVASELPVSIEGVVALVDIGATMTTLNVLRGGRSLYSREQVFGGKQLTDEIMRRYGLSYEEAGLAKRQGGLPESYEMEVLEPFKEATVQQISRLLQFFYAGSEFNRVDHIVLAGGCAVLGGLPEMVEEQLGVPTVIANPLAQMTLGPKVNAHALAQDAPALMIATGLALRSFD
>NZ_AP021867.1|WP_012511976.1|3633896_3634769_-|PilN-domain-containing-protein
MARINLLPWRAERRKQRQREFYAMLGMAAIGGLLLSLVIWFYYDRQVSGQMDRNAYLEAEIEKVKEQNKEIDRLDAQKERLLARKKVIEELQAKRSQMVHLFDALVRTIPDGVVLTALKQEGDVLTLEGRTQSNARVSAYMRNLDTSGWMTNPELSIIEARDPEKDKDGKAGPVADMKALPYVFVVKVKLPAQSEEVAATPGLNADGTVAPAAPAPVAPLAAGPDAATPAAPAAGQPAAAPAAPAAPAAVPANPPAAPNQPAAKPAPKPEGSRLAQPPQAFHAPLQGDRA
>NZ_AP021867.1|WP_006388913.1|3633243_3633900_-|type-4a-pilus-biogenesis-protein-PilO
MSQKIDLKNLDFNDIGNWPQKAKIVFCSLLALVIMFVAWMLLISGKREELAGLESKEVELRTEFTKQQERAVNLAPLKQQLAQMEQVLQQMLRQLPSKTEMPDLIIDISQTALSSGLTNELFEPEQEQVKEFYAEKPIKLRMVGSYHQFGAFVSGVASLPRVVILTMHDINLKPKDKTGGNVRSGALELSGTVKTYRYLDETEVQEQQKAEAGKEDKK
>NZ_AP021867.1|WP_050559910.1|3632713_3633217_-|pilus-assembly-protein-PilP
MAAAVLLLAACGRGVTSTPGDAPNLEKWVEGERARPAQPLEPLPVMQQFETFEYSAQGMRDPFTDAWTNPQGSGGLRPDPNRRKEPLEGFPLDALDMVGTIGTGAGTVALVMGPDKVTYRVRPGGYLGQSDGRATAVFEDRVELIELVPDGAGGWLERPATLSLEDQ
>NZ_AP021867.1|WP_006388908.1|3630718_3632692_-|type-IV-pilus-secretin-PilQ-family-protein
MTFHQAKGLRPVRRSTLNRVSALGVALMLACAPALAAAPAEKPVGTTVAPAAAPAGLSVAKIDFKRGDDGAGRLIVQFDGQGAIPDLRTQGNSVVVDVGNARLPANLQKPMNVVDFATPVQRIDAKPSGAGTQLVLSTGGAVESLAYQSGNEYVVEISPRQAPAAVGAVTAGSVTQAAKALPQRGFTGKPVTFNFQDVPVRTVLQLIAEESNLNVVASDSVQGNVTLRLVNVPWDQALDIVLRAKGLDKRRDGSVIWVAPQAELAKFEQEKEDARIAIENREDLVTDYVQINYHSATQIFKALTEAKGIGGGGGGGAGGGGGGSSSQEDSGFLSGRGRIVADERTNTLMISDIPKKIARMRELINVIDRPVDQVLIESRIVIATDTFARELGAKFGISGSRDNVYFSGNLEANRLTRESQVKTAQDNAKAERDWIAGGRVGPPPVATGSTITRGLNWSLPVATASNPGSLALSILNAGYLLDVELSAMQEESRGEVISNPRVVTTNQREATIKQGKEIGYVTISGGGTGGVATPNVQFKEVVLELKVTPTITNDNRVFLNMQVKKDEVDQLIQLDGYGTVPSINRREVNTAVLVEDGQTVVIGGVYEFTDRSSISKVPFLGDVPFLGNLFKKRGRNKDKAELLVFVTPKVLRVAKQN
>NZ_AP021867.1|WP_041864582.1|3629502_3630528_-|MoxR-family-ATPase
MNLPPPMPETVSPPPAPATSRLHAAFSQLRDALSAEIVGQAALVERLLIALLADGHLLVEGAPGLAKTTAIRALAARLEADFARVQFTPDLLPADLTGTEIWRPQEGRFEFVPGPIFHPILLADEINRAPAKVQSALLEAMGERQVTVGRHTYALPPLFLVMATQNPIEQEGTFPLPEAQLDRFLMHVRIGYPDQAAESEILRLARERARGALGESAPVPEKMPMQDVFDARREVLDLHMAPALERYLIELVLASRDPSRYDAGLGRRIAWGASPRGSIALERCARARAWLADRDFVTPDDVRAVAADVLRHRVLPSYEATAEGWDGERLVQELLARVPAP
>NZ_AP021867.1|WP_065723814.1|3628564_3629494_-|DUF58-domain-containing-protein
MTDRSLEHVPSVSDGDGLRPQLAELVALRRLAQRPPPPRRGRAGNAGQAPSPLRGRGMEYAESREYVAGDDARHIDWRVTARTGRAHTKLFQAERERVSLIVADTSPSLYFGTRVRFKSVQAARAGAVAAWSAQRRGDRIGALRGSDREPPIAPAGGPRGVLRVLDALTRWYAQPPADDLGLERALDHAGRVLRPGARMLVLADPQQAIRIPPARWSALAQHHDLSLVLLVDPLELQPPSAALQFQTLQQRIGLDLRRSEVQAHWQAHFVEPLQELRRQLGARRVDVQVLSTDAPSDAWLAPSPTEVPA
>NZ_AP021867.1|WP_012511972.1|3628118_3628568_-|DUF4381-family-protein
MSANLPLRDVQLPPPPSWWPPAPGYLMIGGVLLLVLLVVAVLWWRRRRRHQRWLQLFDQELAASHDAVAELAAIAGLLRRAARHARPGSESLRDEAWWQRVDPQGTLPEARRSLLAEGAYRPRVDVNEVAAVRRWARERYLALLLERRR
>NZ_AP021867.1|WP_100469430.1|3627117_3628122_-|VWA-domain-containing-protein
MNVLASYWPWPDLQLAWPLALLALPLPLLMHWWKRRADPGAALRVPYAATELEALAGGGRVDVSWLRTLLLWLGWCALCVALARPQQLGEAITPPQEGRQMMLAMDVSGSMGEGDMVLGGQAVDRLTAAKAVLADFLDRRAGDRIGLLVFGDRAYTLTPLTADLASVRDQLRDSVVGLAGRETAIGDAIGLAVKRLRSQPEGQRVLILLTDGVSNAGVLEPLRAAEVARAEGVRIHTVAFGGDGSMRLFGIPISADQDPVDEATLKKIANMTGGQFFRARDTAQLAGIYAELDRLEPIAAKGPSLRPREERYAWALGLALLLGALAWLWPERRR
>NZ_AP021867.1|WP_012511978.1|3638815_3639460_+|hypothetical-protein
MHRARQHAASQTRERRHRLAHEAARLMAEGGIRDYHQAKLKAASRLGIHDDASLPRNTEIEDALREYQRLFSGPQHGNELQRRREAAMRALEFLHGFAPRLAGPVLDGTADANSPVQLHLHSDDPEAVHRFLDEHGIPAESRTRRLRMDRERCLDVPVWVFSAEELTFDLAVLPYDALRQAPLSPVDEKPMRRASVAQLRQVLAEAEITAYIGG
>NZ_AP021867.1|WP_100469442.1|3639741_3640491_-|hypothetical-protein
MYRWVSWFMSYRSFYVWRARYRYYTRHLDAWMLASTLCLMGVVALLWYYWQFTSAPPPRMHPQAAALRVEGITNEAIRRIVLVRHGGTTPGKAFTTPEEIRASTVRTMRVRQVLDGEVAWRLKASLLTDIAEYIDATDGCVPYRCERVQERIAFLREAAEENAGVNRALQAILDEPVDLLPSLEDSDRQRVKSGWSDSFDDIYHQTWLLNDLQRMHARMMAEYPRRAPVSWLPKWMTGSTPEPRNGTPL
>NZ_AP021867.1|WP_153676073.1|3640560_3646005_-|YadA-like-family-protein
MNRIYRRIWSVAKQCWVVGSELSSPRRKSSRTKPRLLVLAAVASVGMSASAQERPKDEYENGEPQEEVARFLSSSPMISSLFAAQPRKIVVQGAIVNDAYYKDSTLNGDMQMILGSRSSINGWGSVVVGTASALAGRGSVLVGNEAIAKGDRAVAVGYKAEATGGYSTVLGASSVASGVGTTAVGHDARAYSQNSIAVGSGARTVESTAGVSRISIGGNAFAGTAGYSGAIAVGGNARAEFSGVALGHHAKALANGSVAIGANSEATEANSVSVGNASTKRRIVNVADARLNATSTDAVSGKQLFATQALAQSVNNRVDATALALGNGAVAESDTSRGASTALGNNAKGYNGASVALGDDARAGVDVAGNKVNGRTGGVSVGSGTRSAHGAVAMGHKAVAGGNFSVAIGSDAVANEELSTAFGKTSIAGAQQTTALGRGTQATAKFATAVGNLARATGINSLALGNSAHAGHEDSVAIGAGSVTASASSVSVGSASRKRKIQYVADGVVGAGSTDAITGNQLFQTNTRLAAVEKTAGDVTGELAAVKSIAKAATNRIDATTLALGNGATAESGSYGISTALGNNAKAYNGRSVALGDDARAGVDADGNKVANQNAGVSVGAGTRSANGAVATGFRANASGNFSIAVGGDAKAEAEHATAVGYLSKAGASQATALGRGSEATAQFASALGNLAKATNTSSVALGDRAQASHENAVALGAGAVTASANSVSVGSASRKRKIQYIADGVVGAGSTDAITGNQLHVTNQAVTKAQTAADGATTIANAAKVESGKALAETVVLGGLVNQTAANGSVRLGQKNSGTQLDVRNSANANRKIVGVAEGAISATSNEAVTGKQLHETNANVNSAQATASAAKVSADKALADTGVLNGLVGQVAVNGNVRVGEKNSGTVLDVRNSADANRKLTGVADGVVGASSYEAVNGRQLNTTNDKVATVEGIARSAGTEAAVAKTDAAKALTETAALGGLVAQVSASGNVRLGEKNSGTTLDVRNSTNANRRISGVADGLLSASSAEAVSGKQLHSTNSRVSDLEDVAQFVSIGSAPISERAAAGVAGVAVGNSAKTGLEGGTAVGTFAEAMGRNSTAIGRAASVSVDSENGFAMGVGAQVGGDAGGARGGVAIGAGASVEGGAHGSLALGMGSQADEVGVVSFGSVGIQRRLVNIARGTAGHNATTVSQLNDSLATLGGGAGMDGNGNIIAPTYTLQGGTQNTVEDALTALDGAVITAGRRADKVEGQLSSIFQDSPSARADGTRQIALNGVNGMVLTNLADGRVAQGSRDAVTGNQLYAAEQKISQNRNDLEAMRKKREMGQQAMREMDANGPIDFGGARLTGVGDGSVSGDSHDVVTGRQLFGVSDRVSKIEHQGRFLKINTDELSEDAFAGFLGVAIGDSARTGADGGTALGAYAAALGVNSVALGRGSYVEERAVGGFAVGAGSQVSAQHGIAMGSGAKVGAGAVWSVAVGAGSEATEANTVSFGSLAAGRRLVNVANGTANHNAATVGQLRGALSALGGEVDAQGNIVGPRFNVQGQTQSTLNGALEALDGAVVTNTSRVDKVETQLRSVFQDTPSVRADGVNQLTLAGTNGMVISNVANGLIAAGSRDAVNGGQLHLMQQQLNGRMDGLEQRIDDAPTPRALASSSVPKPQAEETPVVPEGKDSQQVASLGEGDKPTPQPKANKDESPKPQVDTAELEKMLARANEYTDGAISNVERRLDKMDKRFNRMAAMSSAQTAMAMNTAGLATYNRLGAGVGYAEGESAMAVGYQRVLNEKGSATFSLNGAFTNSGERSMGVGVGIGW
>NZ_AP021867.1|WP_100469448.1|3646066_3646774_-|pilus-assembly-protein
MKKLLFCLLPLSALLAPPAQANLSIHPMRAAVDAKHGTKIRVYSQSTQPQYVQARLLRINNPAQVGEQEIEVEAADAAIAITPGKFALSGGGNRLIRVIPLQTVEKEAAYRIYFEGVNGPDGTILEGDEQAAQANVGVSLVWGALVNVVPAKGTVDLQLQGNTLRNTGTLRVGITGASECNAAGVCAPHELSKSLYPDAALTLPFQLQPGSTLQLQYRLSNDGYRDHIATLSPSA
>NZ_AP021867.1|WP_012511982.1|3646792_3647944_-|hypothetical-protein
MNRRVLLVLMLVCALVVLAPRAWAQWPPETHPTDQSRDIVMTWDRSAVPGDVELWAPRTVLGFSHDLAMKYGQIHVVCGSASDSEFGRCPTEGDLTSSGGTGTTEIALRLVELRTGLRTEIRAVGNLQRVMSGYRCNLDYWDSVPRVLNAAFWYTCGIGSGADQPLGTGVEMILPQREISRLVAGHWKATMRLNIKADPAAAPVATATFNFDFTVTDYDAISIYFPGFDGVAPLVNMDLRYDPIRKVVAGRKDVDMCLYDGVGSQSEFLGVTVRDSGPRPSPGRDFAVWHQDGGSDDTQRLDYQVGLSYGGNLLAMKHGEEQLLRGIDSAQLRMVLLPGISQPVYCVPTPLTLETPPTPIAGKRPGLYDGELTVELRVPTAKP
>NZ_AP021867.1|WP_100469451.1|3647940_3650673_-|TcfC-E-set-like-domain-containing-protein
MTPHAPAITRLAVALALALATPLAAARGVPPGFEDLVEGQTEQLDIQLFGRSAGLSPVRVTLEHVQLEDPASVLQALDLPAEAQAVLLPALSQPMARNSHLACRFGGATAGCGYLDPPDDPAAVRALFDEGEGAVRLFVARQWIPGKPAAERFHTVSANAENAFLHQQVINVSGSRDYQTLSARGTGVRGLFDRGHVSAEWNFNQQRYRSRGSDSAFQFDNVYYRHDLGQAHYLQAGRMDRRNLSSPQGGTFSFSMLPLDRFQGLRVGTTQAYVDADAAVQATPLTVLLARDARVDAYDGTRLLQTSYLQAGINQIDTRNFPFGNYTITLRIYEDGVLVRSEDAPFDKGGDWTNSQWQWFVQGGKRNERRSDRFDGERVAVAGMRVPLGRDVAVVAGAADLGGFRYGELRVDLRRLYATQELRASFGGMRGNDGSTGQQHQLSYRRTASWNIYQQRMRGKACQFEADARDQLGCTNSLSASMALPLAGGSAYVGYTRRQTWRAGRILPGTEDDPLAGLDPLLPPPPPWQPRREPQLSRTWQASFSRSHRWQDFSVSTRVGVWQQRASDSLRGSDQRDRGIYFNLSLTRLLRGTAGSGQRRYSVDVRQPQHQRPDINYSVGHSLRQEVDAQYRELSAELRANNSDRYSATLSGQLQNSLGQSGATLAHYQQRGRSETAYSGMHSSGFALGKRGFYWSGSNGADAGLAVQVADTDDVDLRGVAAELQVGGLRRQRLQIGERRLLPLSSYQSHRAEVQDASTLDSIAAIRVTGVGGARPMFLTPGRLMRMPVPIEVTYTFIGNAKDLAGAPLGGARILNAPVPGTSANGGFVADFPRRETTLYLLQDDRLLHCPLQVRERRQVVLLVGAVHCEPLAVAQLPPEIRQQARVTRLLQERALIAATPQTAAAGGTP
>NZ_AP021867.1|WP_100469454.1|3650734_3651235_-|fimbrial-protein
MNAILKKAALAAALATASLSAHAVETKITVYADVDPTLALLRDDGSALPDAVTLTHDPLRGLIPDTQHVRIHSNDSAADIEAKIGGAFVLANGDGKITVPMTVSLNNRALGLTAVEFKAADLFTGAGSTPGASISMPLVIAQTAPAPLTNQGRYSGVVNIVLSQKP
>NZ_AP021867.1|WP_100469457.1|3651831_3652590_-|alpha/beta-hydrolase
MANTFHRVGQGPHSVLVLHGWFGDAHAFEPIEPWLSRDHFSYIFMDCRGYGGMRGVAGQYSIDEIARDALSLADALQLETFSVAGHSMGGMAIERIAVLAPQRVRSMLAIAPVPCGGIAYDASTRSLLENASGSVASRRAIIDRSTGGRLPAAWLDWKARYSMEHSTPDAFAAYLPAWADTDFSDEIVGEHRLKVVVGGNDPTFNRSLMECTYLRRYRQATLQVLEDAGHYPMNETPLVLVEAMESFLLPSP
>NZ_AP021867.1|WP_100469460.1|3652683_3653457_+|helix-turn-helix-transcriptional-regulator
MRNSLLDPYEDLPRDVVVTSNDYAASSTFPRHAHRRGQFAFAARGTISVTTPQGRWLVPPQRACWVPAGLAHEMTMRGPVTMLNAFLSTDAAAAVAMPAQCHVYAVSPLLRQLLEGAVDLPALYDEDGRAGKLMQLLVAEIASMPMLSLHAPLPADARLARVCRALFDAPSLAIGLDKVAADAGMSRRTFTRTFRADTGVSFAEWRQQVCLLAAIERLGQGQAVTRVALDLGYASPSAFSAAFRRELGCSPSRYSEV
>NZ_AP021867.1|WP_012511988.1|3653606_3654884_-|citrate-synthase
MSDLDQVTLNAGDKSVVLPVIKPTLGNDCVDIAKLTKETGYFTYDSGFTATASCKSAITYIDGDKGVLLYRGYPIEQLSEKSSYVEVAYLLINGERPSAEQLKAFTDELAAEANVDASINTLIGSFAKDAHPMAILTAAIAQLSGIYHASLDLADAEQRRQAAVRLIAKVPTLSALIYRHGKGLPANKPDTSLDYVSRFLKQTFESADGQYDLNPDVVKALDLLFILHADHEQNASTSTVRLVGSTGANPYASVAAGVTALWGPAHGGANEAVLKMLEEIGTADNVESAVLKAKDKTSGFRLMGFGHRVYKNFDPRAKVIGEMTGKVLKQLGVQDPLLDVAVKLEQAALQDEYFVARKLYPNVDFYSGIIYKALQIPTEMFTVMFALGRTSGWVSHWLEQQVDPEMKIGRPRQVYTGSDVRDYQG

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Crispr_ID: NZ_AP021867_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP021867_12

3850380-3850459

Orphan

Consensus_repeat	Method
CGACCAAGGTCGACACCTACCAGAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP021867_12

>merge|NZ_AP021867|12|3850380-3850459|CRISPRCasFinder
CGACCAAGGTCGACACCTACCAGAGCAGGTTCATGGCGTCGGCGGAATAGGTGCCGACCAAGGTCGGCACCTACCAGAGC

>NZ_AP021867|12|12|3850380-3850459|CRISPRCasFinder
CGACCAAGGTCGACACCTACCAGAGC	AGGTTCATGGCGTCGGCGGAATAGGTGC
CGACCAAGGTCGGCACCTACCAGAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP021867.1\|WP_100469548.1\|3849174_3850338_-\|peptidase	unknown	unknown	gnl\|CDD\|367567
NZ_AP021867.1\|WP_006391724.1\|3863837_3866195_+\|family-20-glycosylhydrolase	unknown	unknown	gnl\|CDD\|119333
NZ_AP021867.1\|WP_012512102.1\|3844692_3846678_+\|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl\|CDD\|183236
NZ_AP021867.1\|WP_100469560.1\|3858188_3859478_-\|sugar-MFS-transporter	unknown	unknown	gnl\|CDD\|340952
NZ_AP021867.1\|WP_006391719.1\|3857081_3858149_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380487
NZ_AP021867.1\|WP_100469563.1\|3861017_3863726_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|273804
NZ_AP021867.1\|WP_012512112.1\|3859854_3860874_+\|glucokinase	unknown	unknown	gnl\|CDD\|237092
NZ_AP021867.1\|WP_100469554.1\|3853830_3854898_-\|DUF1624-domain-containing-protein	unknown	unknown	gnl\|CDD\|226749
NZ_AP021867.1\|WP_006391684.1\|3848835_3849171_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_006391637.1\|3844133_3844541_-\|biopolymer-transporter-ExbD	unknown	unknown	gnl\|CDD\|223917
NZ_AP021867.1\|WP_006391716.1\|3856045_3857074_-\|SIS-domain-containing-protein	unknown	unknown	gnl\|CDD\|225132
NZ_AP021867.1\|WP_012512104.1\|3848351_3848786_-\|SseB-family-protein	unknown	unknown	gnl\|CDD\|377787
NZ_AP021867.1\|WP_153676087.1\|3850490_3853520_-\|autotransporter-outer-membrane-beta-barrel-domain-containing-protein	unknown	unknown	gnl\|CDD\|238654
NZ_AP021867.1\|WP_100469545.1\|3847061_3848282_+\|multifunctional-CCA-addition/repair-protein	unknown	unknown	gnl\|CDD\|182810
NZ_AP021867.1\|WP_153676086.1\|3843518_3844124_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_100469557.1\|3854897_3856046_-\|N-acetylglucosamine-6-phosphate-deacetylase	unknown	unknown	gnl\|CDD\|224733
NZ_AP021867.1\|WP_012512115.1\|3866407_3866800_-\|membrane-protein	unknown	unknown	gnl\|CDD\|227939
NZ_AP021867.1\|WP_012512101.1\|3840558_3843420_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NZ_AP021867.1\|WP_100469539.1\|3838271_3840410_+\|ferric-rhodotorulic-acid/ferric-coprogen-receptor-FhuE	unknown	unknown	gnl\|CDD\|236640
NZ_AP021867.1\|WP_100469542.1\|3846783_3847020_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP021867.1\|WP_100469548.1\|3849174_3850338_-\|peptidase	gnl\|CDD\|367567	pfam03572, Peptidase_S41, Peptidase family S41.	2.69928e-12
NZ_AP021867.1\|WP_006391724.1\|3863837_3866195_+\|family-20-glycosylhydrolase	gnl\|CDD\|119333	cd06563, GH20_chitobiase-like, The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. This GH20 domain family includes an N-acetylglucosamidase (GlcNAcase A) from Pseudoalteromonas piscicida and an N-acetylhexosaminidase (SpHex) from Streptomyces plicatus. SpHex lacks the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself.	0
NZ_AP021867.1\|WP_100469557.1\|3854897_3856046_-\|N-acetylglucosamine-6-phosphate-deacetylase	gnl\|CDD\|224733	COG1820, NagA, N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism].	1.42088e-163
NZ_AP021867.1\|WP_100469560.1\|3858188_3859478_-\|sugar-MFS-transporter	gnl\|CDD\|340952	cd17394, MFS_FucP_like, Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters. This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.0274e-121
NZ_AP021867.1\|WP_006391719.1\|3857081_3858149_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380487	cd01545, PBP1_SalR, ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators. Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators. The SalR binds to glucose based compound Salicin which is chemically related to aspirin. The ligand-binding of SalR is structurally homologous to the periplasmic sugar-binding domain of ABC-transporters and both domains contain the type 1 periplasmic binding protein-like fold. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the type 1 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	6.33601e-118
NZ_AP021867.1\|WP_100469563.1\|3861017_3863726_+\|TonB-dependent-receptor	gnl\|CDD\|273804	TIGR01782, TonB-dependent_receptor, TonB-dependent receptor. This model represents a family of TonB-dependent outer-membrane receptors which are found mainly in Xanthomonas and Caulobacter. These appear to represent the expansion of a paralogous family in that the 22 X. axonopodis (21 in X. campestris) and 18 C. crescentus sequences are more closely related to each other than any of the many TonB-dependent receptors found in other species. In fact, the Crescentus and Xanthomonas sequences are inseparable on a phylogenetic tree using a PAM-weighted neighbor-joining method, indicating that one of the two genuses may have acquired this set of receptors from the other. The mechanism by which this family is shared between Xanthomonas, a gamma proteobacterial plant pathogen and Caulobacter, an alpha proteobacterial aquatic organism is unclear. [Transport and binding proteins, Porins].	1.74592e-174
NZ_AP021867.1\|WP_100469554.1\|3853830_3854898_-\|DUF1624-domain-containing-protein	gnl\|CDD\|226749	COG4299, COG4299, Uncharacterized protein conserved in bacteria [Function unknown].	1.01963e-49
NZ_AP021867.1\|WP_006391637.1\|3844133_3844541_-\|biopolymer-transporter-ExbD	gnl\|CDD\|223917	COG0848, ExbD, Biopolymer transport protein [Intracellular trafficking and secretion].	6.8355e-32
NZ_AP021867.1\|WP_006391716.1\|3856045_3857074_-\|SIS-domain-containing-protein	gnl\|CDD\|225132	COG2222, AgaS, Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane].	5.2344e-114
NZ_AP021867.1\|WP_012512104.1\|3848351_3848786_-\|SseB-family-protein	gnl\|CDD\|377787	pfam07179, SseB, SseB protein N-terminal domain. This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon. This entry contains the presumed N-terminal domain of SseB.	1.59862e-09
NZ_AP021867.1\|WP_153676087.1\|3850490_3853520_-\|autotransporter-outer-membrane-beta-barrel-domain-containing-protein	gnl\|CDD\|238654	cd01344, PL2_Passenger_AT, Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43, AIDA-1 and IcsA, as well as, the less characterized ShdA, MisL, and BapA autotransporters.	9.67892e-39
NZ_AP021867.1\|WP_100469545.1\|3847061_3848282_+\|multifunctional-CCA-addition/repair-protein	gnl\|CDD\|182810	PRK10885, cca, multifunctional CCA addition/repair protein.	0
NZ_AP021867.1\|WP_012512112.1\|3859854_3860874_+\|glucokinase	gnl\|CDD\|237092	PRK12408, PRK12408, glucokinase; Provisional.	0
NZ_AP021867.1\|WP_012512102.1\|3844692_3846678_+\|transglycosylase-SLT-domain-containing-protein	gnl\|CDD\|183236	PRK11619, PRK11619, lytic murein transglycosylase; Provisional.	1.11687e-72
NZ_AP021867.1\|WP_012512115.1\|3866407_3866800_-\|membrane-protein	gnl\|CDD\|227939	COG5652, COG5652, Predicted integral membrane protein [Function unknown].	0.000634737
NZ_AP021867.1\|WP_012512101.1\|3840558_3843420_-\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	2.14684e-28
NZ_AP021867.1\|WP_100469539.1\|3838271_3840410_+\|ferric-rhodotorulic-acid/ferric-coprogen-receptor-FhuE	gnl\|CDD\|236640	PRK10003, PRK10003, ferric-rhodotorulic acid outer membrane transporter; Provisional.	0

>NZ_AP021867.1|WP_100469548.1|3849174_3850338_-|peptidase
MLGCFSRNPPNPSMGSALQHTGAWRDRSRHGYPKASIHDKESSMLDLRSVRAAMLATLLLSSAAAVAEETVELPSPEAREQMLQLLETQSLYRDRVDWNDVRARLTAAGDDRAQQRRVLDETAARSSGGHGRWFSPSEQRQRSERAQRLNAGQATALAAPRHANPRIGVLRVSPFVEDLQRSEPERYEARKVYALALQERIAGLDDGTRCGWVVDVSSNGGGNMWPMLFGLLPLLHGTPDTQGALIGAFRSANGLLWWRQAEGEVVQGNASMLRSRQGAYRLRVGTAPVAVVMGAGTASSGEAVALAFRGQPGSRSFGQPSAGFSTGNRPTTLVDGTTLLLTHNVMTDRNGQGDGGRMQPDQATPSGPATLAAAQAWLLAQPACQGS
>NZ_AP021867.1|WP_006391684.1|3848835_3849171_-|hypothetical-protein
MILIGQHERVVTVGPTEAHHCLRCQTETEFAPQLRYRMARIDLLFGLTYHRRYELACSRCGHGWVLDTDTMDQQLGGVPIPWRHRFGLPLMLVVVVGLALSGWLWRHGFIG
>NZ_AP021867.1|WP_012512104.1|3848351_3848786_-|SseB-family-protein
MDHDTPFEPLNDLEVRLLQAQDGTLTASQFLDGLLTSTAFVLLDKAIGEDGAWDESISPLVLTSESGEAMFAVFTAPERAGLWHEQLPQFAHAMPIAVHALLAGIGDGVGLVLNPGLDVGMEMIPDAVAQLKQRAAAITRGMAH
>NZ_AP021867.1|WP_100469545.1|3847061_3848282_+|multifunctional-CCA-addition/repair-protein
MKIYLVGGAVRDRLLQRPSGDRDWVVVGATPAQMEAQGYSAVGRDFPVFLHPKTGEEYALARTERKSGRGYRGFVVDADPAVTLEEDLQRRDFTINAIACDEDTGTLVDPYGGVRDIEQRVLRHVGPAFVEDPLRVLRAARFMARFAPLDFTVAPETMDLMRNVAASGELDALVPERVWQELRKALVSAQPSAFLRTLHDAHALGPILPELEALYGVPQRAEFHPEVDTGIHQEMVSDMAAKLAPGDDLVGFAALTHDLGKGLTPPEEWPRHIMHEQRGIKPLKELCARLRVPTEHQQLAEAVCREHLNVHRIDELRDATVLELLGRCDALRRPERVARIALCCEADKRGRLGFEDSDYPQGETLKRLHQAALSVQARDLDTTHLKGPAIGEALAKARVKAIAAAR
>NZ_AP021867.1|WP_100469542.1|3846783_3847020_+|hypothetical-protein
MSLLVWIGMFTAWSLFATWVLRWGGAAWMEGWKSLAFVDSWGSLWDEAQIKLYFLCLWIVYGLWFVAGLFVPEWRGLS
>NZ_AP021867.1|WP_012512102.1|3844692_3846678_+|transglycosylase-SLT-domain-containing-protein
MLVAMTRRSSTALSLLPLATTLLIGCANAQSLDAQNAQLKAAIAAAERGQFDPGQAAALSRHPAYGWLEYANLRRNIDTVDTAQAQAFLKRYDGQAVANTFRSVWLPSVARRQDWPTLLANWTPTDNAGLRCAQLTARQVTGKVDPQWISEAQDLWRKNGKSLPDGCDAVFAVLQAQGGLSDALRWERIDAAADAQQPAVMRSAARGLPATDLALANNYAAFVDKPNASALNWPRNERSRRIATDGLAKLAKADPGATEQQLPQYAQALGLSAEQSGQVLYQIALWTVASYLPDSARRLNAVPESAYDERLHEWRVREAMSRGDWPAALTAIRKMASKQRSDPRWRYFEGRMLEKTGQAQQAQALFREAARAPTFHGFLAADKLQQGYTLCPWKPNDSAQAQATIARDPAIQRAMALYQIDRAGWAVAEWNSALSRFDDTQRRLAVRVAQDNGWFDRAVFALGKQPQEQRLYDLRFPLHHDATIRRESARNAIDPAWVAAEIRAESTFTPRARSPANAMGLMQVLPATGAGVAKSIGLTGYGGADSLYDPDTNIAIGTAYLRQLMNKYDGLPYVTIAAYNAGPTPTARWQSQRPGYDPDLWIETISYKETREYVARVLAFSVIYDWRLNGDALPLSDRLMGRLVDKRKSFSCAANADQGGD
>NZ_AP021867.1|WP_006391637.1|3844133_3844541_-|biopolymer-transporter-ExbD
MAFSSAGTGSPLAEINVTPLVDVMLVLLIIFIVTAPIVARPIAVQLPQATDRVVDRPEPPPPIELRLDAANQLSWNGQPMAIGDLQARLQVQAGEHAGNLPELRIATDPAAEYEGMARILAAAETTGVERIAFVR
>NZ_AP021867.1|WP_153676086.1|3843518_3844124_+|hypothetical-protein
MMIDTLSRGFDAFSGGLRQIAAGYDRTILFTTGSLDAGCDSARRQLPHSWKRSLPDRFRNSLKFLLSEGAANRSSADSHLQPFAGGSIMKAVSAVLGVTTVMTLLLSPASESRAGGLIECNNCPSPSDAALASGEGLTVVVDFERAELTAFDVEHEPKAKKWRAHPTPVPAQIETAFLRILDATLSAGEAPLMQQSPHERQ
>NZ_AP021867.1|WP_012512101.1|3840558_3843420_-|TonB-dependent-receptor
MIHLHHRPLAVAVALCVTALAPLGAAAQSTTNLDAVEVTGTRIKRAEVEGQVPIQTLTRGDIERTGLTSIGEVLQQLTGSGSALNAKFNSSGNFGFPPDGSGVGAGSAQVDLRHLGAKRVLVLVDGIRWVNESSASGVGSATDLNTIPLAIVERIEVLEDGASSLYGSDAIAGVVNIITRRDFDGGQVTLNYGEYSKGDGTQKGVDLAWGKSGDRYSLFLGASWTKQDPVFAKDREQSRFPIPGTGLAFGSGGIPQGRFRFTDPNTGAVQDIVPNTGASNPRYDGSAGCNRSDDYHCFTSADRFNFAEYNMVLTPSERKGLFGQFRFDITDNVQWYVKALGNRRESTNQAGPEPLFFGPDGATGNPLADNIVVSRLNPYNPFGFDLVSSGNMALIGRRPVEGGARVFEQKVDTTYFATGLVGDFHAADRSWYWDVNGMYSKNKAEQTNYGSYNIYNVNMALGDPAICAATPGCVPLNIFGGVGSITPDMLKWIQPVVRDRSQNELSLFTANLSSELFSLPAGPVSFATGFEYRKYEGSYQPDPLTVAGHYNGVPSQPTSGSYDVNEAYLELSVPIFADSSFGKKLDLSLAGRYSDYSTFGGEFTPKYGLRWQVTDDFVLRTTYAEGFRAPSIGELYGSAARADLQLFDPCSVGLGGTPPRGSAANCAALGVPAGFQQANSQISVTTGGNRELDPERSRSFSAGFVWSPWFGNNTSWSERFDVEVTFYRHAIDGAIQAINAQTQLDLCVDTLDPIYCEGITRANTGAVSSFNNRLTNLGSIKTDGWDVDLFWTLPQSSIGQFKLGWKNTFVGRYEATGAAGQKQPQKPGVEVADSSIPEWTSNASIGWTLDRWSANWTVRHISELTENCGDAAAFPVCSNQAAGTNTLSATTFHDMQVGYKIDWMKGLQLTAGLNNVFDKDPPICLSCSLNGYDASTYDIPRGRYWYLRADLRF
>NZ_AP021867.1|WP_100469539.1|3838271_3840410_+|ferric-rhodotorulic-acid/ferric-coprogen-receptor-FhuE
MTRPAFRTLQPQRLSIAVFAALCSVAPTAFADTTADPTTLDKVVVKGERAEGYSVRRTSAGTRFDLAPREIPQSVSIISHQRIEDQKLDDIIDVLANTTGVTSTQSDSERTEFYARGFYIDAYQFDGLPTQMVQNWSYGDSGLDLALYDRVEVVRGATGLLSGAGNPSASVNLIRKHADSAELTGSVSVNVGSWGRTRTTVDVGSALNASGTVRGRVIGSYLDTDGQMDRYNQRKTLGYAVIDADLTPDTQLSVGYDYQQKRANGATWGGFPMWYADGSPTNYPTSFNPSPDWTYWDTTSKRAFATLQHAFSNGWKFKIGATHDRTEADDKLFYPAYTAFNKNTGAGVTPMAGFYNTERKVDGIDGYVDGPFQLFGREHQFMAGLSYNKREFANYGDFQMGGPGTGWNPFSSYLNWTGNITQPNWNPLALASQGTITQKAGYAAARLSLADPLKLILGARYTNWKSEGENDDREHKVTTPYAGLVYDINDTYTAYASYTEIFQPQTARDRNDRYLDPVDGKSYEVGVKGAWFDNRLNASLAVFRIEQDNVAQATSEPIIGRPGEFASIAARGTVSRGFEFEVNGELAPGWNATFGASRYVAKDINGADINTNLPQTALKLFTSYTPQSLQALTVGGGANWQNRIYYAAPVVGRFEQEGYALVSAFVRYRISPEFSVQANLNNLLDKKYYSQITGYGAYGDGRNGSLTFTWAF
>NZ_AP021867.1|WP_153676087.1|3850490_3853520_-|autotransporter-outer-membrane-beta-barrel-domain-containing-protein
MSRAVPRAFRPRRLAVSVLQALAVPSLLLTTAGVAWAGCNNPAPTAGQTVTCDANAPNPQTVPITASGVAGITVNVANGAQLQQNGGGSAIALVGAGGHLLSNQGAISSVGGVAVQLGGGSRVENLGSISTGNTIALQFVGGGNSVLINRGAISGRTGVQFDAGNDRLEMQAGSIAGGVLQGDGNDVLQLSDGTIDSVDQGTGDDQVTVTGGTVTGVVVQGSGRDDFVMSGGTIGALQQGDNIDTFRMSGGRIIGAFEDGDQAWMTAGRVGRVNMKLDKNLWDQSGGIVEGNVVTGFDIDTIIISGTAYIGGNISVSGGADSVTITDGTVRGQVLLSTGNDIFNWRGGGIVYGAIDMGPDNDVANLGSLNHANLGAVPLFDGGSGIDQLNFNNVKTAGVGRFQNWETISLANSTELTFDGDLVLGDSGTGTGTLTVDDTSTVYAGSGGHAVRPFNSGALVEMVNAGRIDLTDTGAGDVFTVRGNYRGDGGGLYLRTVLGADNSTSDRLVIDGGTATGTTGIGVLNAGGSGAATLADGILVVQALNGATTSPGAFSLFAPVAAGAYEYFLFKGGVSSGSGENWYLRSTVVAGPAPAPNGIGVNTTPPPPTPPVAPPPPITPAPPPPPEGATDPDLTAGETAPPPPPPEPAPVAPPSDPAVPDVPVADGSLPGIGTPPTPGARPAEGAVVPLYRVETATYAVVPPLLRETSLASLGTFHERQGEQRLLYNQGAFRTAWGRLVGQSSEIHWKGDAQPGFDGDVMGLQAGLDVWAAANDSHRNQIGVFVGRTRAQGKTTGLALGWENVQVGQNRLDDKHVGLYWTFTDSRGGYIDAVAMQSRYDGRARSSRGLGFGIKGDGTSVSVEAGKPLLHFGQSAWWLEPQVQVIWQRTALDDRRDEVSSVRFDNDNAWTGRVGLRLAGDYQLADNGWQPYFKLNYWHGRSGDDRIHFDDDVIINSQRSRSLEAGVGVVGRFNRTISAYAVADYTRELGGDRNEKRRIIEGNIGLRADW
>NZ_AP021867.1|WP_100469554.1|3853830_3854898_-|DUF1624-domain-containing-protein
MNSSPPRRLGSIDALRGITVAAMLLVNNPGDWSAVFAPLRHSEWHGCTPTDLVFPFFLFLVGVSMAFSVAPRALDVALRPALARGVLERALRILVAGALLHLLIWWALDTHHFRIWGVLQRIAVCAALVGVLAVYALPRVQVGALIVLLVGYTVLLLGIGDLAPWTNPASRLDTALFAPWIYQWHADTGLGHDPEGLLSTLGALASTVLGLLAGGLLRNRRTAALAGLGAVAAVLGLLLAVVLPLNKQLWTPSYVLWTGGLAALALWLGYVLIDQKGWPALGRRFGVNAITAYLGASVMSVVLMATGAWGWIWQQLATAMPQTLELASMLQALVFVALWWGVAWWLDRRKIYLKI
>NZ_AP021867.1|WP_100469557.1|3854897_3856046_-|N-acetylglucosamine-6-phosphate-deacetylase
MATVLRNARVLAGDEFRDDLAVVIEHGRISALLPDAAPQLGQAAEQVDLGGGWLLPGFIDVQVNGGGGALFNNTPDVASLRTIAQAHRRFGTTAMLPTLISDDVGVMREAIDALREAIAQGVPGVIGIHLEGPYIAPARKGTHDASKFRVPDEAEIALAASLDNGVTLLTLAPERVPLETIRALVERGVIVAAGHTAGTYEEIRAGLDAGVRGFTHLYNAMSPLQGREPGAVGAALEDRDSWIGIIVDGVHVHPASLRVALAAKPRGRLLLVTDAMPPVGADDPSYVLYGETITAIDGVVRNAAGSLAGSALDMATAVRNTVQLLGQPLAEAARMASTYPAQFLNVDDRLGHIAEGYQADLVLLDDALRVRGTWIAGQYEAA
>NZ_AP021867.1|WP_006391716.1|3856045_3857074_-|SIS-domain-containing-protein
MSLSDPTATLMFAEAAEAADVVARQFSRNHATMETLAASLRAAPPPFVVTCARGSSDHAATYGKYLLETQLGLVVASASPSVGSVYAAPLQLRGALFIVISQSGKSPDLLRNAEAAKAAGARVIALVNVEDSPLAQLADTVIPLHAGAEKSVAATKSYLASLAALLQLAAYWKQDASLRAALDLLPDAMREAWQCDWTSVTEGLVDATNLFVLGRGLGLGAAQEAALKFKETCSLHAEAYSSAEVKHGPMALVDRGFPVLAFAQPDETGAGTRAVVEEFTARGAQVWMAGAGGNLPVAAAPHPLCAPLLTVQSFYRAINALALRRGFNPDLPPHLNKVTETV
>NZ_AP021867.1|WP_006391719.1|3857081_3858149_-|LacI-family-DNA-binding-transcriptional-regulator
MRRATIKDVAEKAKVSLKTVSRVINNEPSVMQATRARVLRAIAELDYEPDPSARNLRSGTTFVIGLVYDNPNPYHIIGVQNGVLAACRETGFGLQIHPCDSSSPLLADELADWVQRSRLAGLVLTAPMSERRDLIQALTARGIKLVRIIAATEDPADGACVFVDDREAAYEITEHLIQLGHQRIGFLWGGISHRSSGERYAGYEAALKDYGMTVDKHLVVQGDYTFDDGFRGARRLLALREPPTAIFGSNDEIAAGVLAAAKSAGMNVPYDLSIAGFEDSPFSRQSWPPLTTAKQATEDIARHAARLLIAQLRSDAYDDAPAPLHNQGFVPQLVVRGSTAPMRPAGARPLPSDPA
>NZ_AP021867.1|WP_100469560.1|3858188_3859478_-|sugar-MFS-transporter
MSAVPAVSARPNVATSIAIVGVLFFLIGFFTWLNGPLITFVKLAFELSEVGAFLVLMVFYLSYFFLALPASWILRRTGMKKGLSLSLLVMAGGAALFGEFATQRWYPGALGGLFVIGSGLALLQTAINPYISILGPIETAARRIALMGICNKIAGMLAPVLIGTVVLHGIGDLSATVAAADEATKAQLLNEFAAKIHAPYLAMAGLLVVLAVAVLFSPLPEIKSSEANATPVAAGAAERRSIFQFPHLWLGVLCLFVYVGVEVMAGDAIGTYGHGFDLPLDQTKMFTSLTLGAMLVGYVVGLLLIPKVVSQSRYLTISAVLGVVFCLGAWATHGYVSVAFVALLGFANAMMWPAIFPLAIRGLGRFTETGSALLVMGIAGGAIIPQLFAVLKQHIDFQLVFVLLMVPCYLYILFYSVIGHRAGLPQDKV
>NZ_AP021867.1|WP_012512112.1|3859854_3860874_+|glucokinase
MTASHPAPAHVLSRVAPSFLAADVGGTHVRVARVQASGDAAHPVQVLEYRKYRNADHAGLSAILSDFLGEGSRPTHCVVASAGYAREDGTVITANLPWPLSARQVEADVGLQRVYIVNDFEAVAYAAAQVDASGVLHLCGPDTAARGPTLVVGPGTGLGAALWIPTAHGPVVLPTEAGQPTLAASTELEMAIVRHMQRDRAHVSIEHAISGPGLMNLYRAVCALQDQAPTLASPDAVTAAAMADTDAHARQALDVFCGLLGSTIGDMALFYGAHGGVYLAGGILPQIREYLRGSTFVERYLQKGPMGEALARIPVKVVEHGQLGVVGAASWYLQQQSAA
>NZ_AP021867.1|WP_100469563.1|3861017_3863726_+|TonB-dependent-receptor
MNTRKTLLSAAIVSCIAFSAHAQQAAQNATDLDTVQVTGIRGSMEKSLDTKRESNARVEVVTAEDVGKLPAHNVADTLQRLPGVNISSSSADEGGFDEADRVSLRGTSPSLTQTLINGHTVGSADWFVLSQGNNVGRSVSYSLLPSELVRSVEVNKSSQAKLQDGGTTGTVNILTRKPLEFSKQFTAEGSIGMVRSDQAKSNDPQLSALFNYKNDEGNFGVMVQAFSQKRELRREAQEVPGGFFQIDPNGTVAKSNPDLAGVYAPGLLGSTLFEQTRERKGGLVSLQFKPLDNLTLGLEGFSSELKANNYNRNFMLWGGRILNDRTVEDANGNKTLIPGQAPNPGYVVKDGVLTNATFAGQADRDYAVYDMIYRESKAKTNYITFDADWQINDNLGMKFQAGNTKGTGDTPRQYIAEVNLARGGGANWSTHGNGSPIDWNVGGNISPGGVTDFGTWGNQQVTAIDKEKWATVDFNQYFSNAGVLNSLDFGARFGDHKREAKSPEGATPGAIWNALKNGATANFPGGFANGIGGSFPRDLWYFTPGALKDAVTNNSTWLSGNDGPTGRHNYGAEWKVSEKNFAAYVQANLSGDRWSGNVGLRYVNIKQDIDTYAAATGSTVPDVSSLFGAWTRQAFDNKHNRVLPSANLKFDLRDDLVLRFAASQTQTLPDFSALGASSYGSDLNRTGGGGNPKLKPVVSTNFDANLEWYFMPRGMLSVGAYSMRLKDYVAFSTEKEMLFSELTNRLEEYNISRPRNADGKVRGIEVAYEQPIGEYFGVNANYTYADGNTEHTWADGSDNLLGTSKNTYNVGAYFENDTFGARLSYTRRSSFLIGLSGANPYYQDDFGTLSASLSYKATDWLSISLDGLNLNNPTYKYYQTAAIPTSFYSNGRQYYLNFRFKY
>NZ_AP021867.1|WP_006391724.1|3863837_3866195_+|family-20-glycosylhydrolase
MVKPSRARMRSAVLLGSLLALLPALPALAADPTPAAEAPGPQLRAGSLMLIPAPSNVQAGQGSGITVRADTVLQAEGEVAQRVAAQFADLLARSGGPRLVLAKGKAAAKTGSIRFQIVPTFRDSGESYTLESTAQGVVIQAGNETGLFYGATTLAQLATGGSNGVLPAVQIQDAPRFSWRGFMLDSARHFQSLDEIKRVLDAMAAHKLNTFHWHLTDDQGWRMEIKRYPKLTEVGSCRLPAGDGGIDPVSGQEHPYCGFYTQEQIREVIAYAAKLHIQVIPEIDVPGHATAAIAAYPELGTIDTPLKPLSEWGVFPNLFNVEDSTVTFLENVLEEVIELFPAKYVHVGGDEAVKDQWEASKQVQQRMHALGIKDEMAMQSHIIKRLETFLEEHDRRLIGWDEILEGGLPPQATVMSWQGTEGGLAAASAGHDVIMSPVGYLYLDYLQTASPNEPPGRPTQVNLGKLYNFEPVPTELAADKRGHILGLQANMFTEHTRSYARLQHNLFPRLAAVAETGWSTPERRDFRDFLARLPAQLQRYRAWGLAYAQTPFEVGVDYTDSRAANTVTLSLANPLGYEVRYSTDGQPVTAQSPLYQQPLTTQLPANVQAAAFYQGQILAARPTVADFSAQSLLSRRSDELLSCVGKKGLVLRLEDDGPREGNRAVFNVDIFQPCWRWPQAQLDGIGSVEVRAGRIPYYFQLAHDEPKRRFEKAKRAHGEMQVRRGDCSGRVLAEVPLPAKPDADGFVTLRATLPKGTQGSADLCINFTGDTRPAMWVLDEVTLGK
>NZ_AP021867.1|WP_012512115.1|3866407_3866800_-|membrane-protein
MSHALPVIKPLQRPRLWAVLWALAVLLVIVVCLIPPPPIPLPENSDKGEHFLAYFILAGSAVQLFRRGRPLLWVGVGLVLMGIGIEFAQGALTSNRMADPMDAIANTIGVLAGMVTALTPLRDLLLRWRG

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Crispr_ID: NZ_AP021867_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP021867_13

4192027-4192137

Orphan

Consensus_repeat	Method
GGTACTGCCGGCCGCTGGCCGGCAACCTCGCGAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP021867_13

>merge|NZ_AP021867|13|4192027-4192137|CRISPRCasFinder
GGTACTGCCGGCCGCTGGCCGGCAACCTCGCGAACCTGCAGCCAGGCATGGCCTGGCTCTACTGCCGGTTGCCTGGGGTAGTGCCGGCCGCTGGCCGGCAACCTCGCGAAC

>NZ_AP021867|13|13|4192027-4192137|CRISPRCasFinder
GGTACTGCCGGCCGCTGGCCGGCAACCTCGCGAAC	CTGCAGCCAGGCATGGCCTGGCTCTACTGCCGGTTGCCTGG
GGTAGTGCCGGCCGCTGGCCGGCAACCTCGCGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP021867.1\|WP_049401666.1\|4183011_4183806_-\|indole-3-glycerol-phosphate-synthase-TrpC	unknown	unknown	gnl\|CDD\|234710
NZ_AP021867.1\|WP_100435362.1\|4192201_4192687_+\|DUF962-domain-containing-protein	unknown	unknown	gnl\|CDD\|226914
NZ_AP021867.1\|WP_153676117.1\|4195848_4196241_+\|Na+/H+-antiporter-subunit-C	unknown	unknown	gnl\|CDD\|236377
NZ_AP021867.1\|WP_006399173.1\|4198553_4198943_+\|Na+/H+-antiporter-subunit-G	unknown	unknown	gnl\|CDD\|237169
NZ_AP021867.1\|WP_153676114.1\|4189337_4189820_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_AP021867.1\|WP_153676111.1\|4184928_4185516_-\|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|235552
NZ_AP021867.1\|WP_046983687.1\|4183880_4184912_-\|anthranilate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234682
NZ_AP021867.1\|WP_006399038.1\|4189879_4190554_-\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|136958
NZ_AP021867.1\|WP_006399169.1\|4197769_4198276_+\|Na+/H+-antiporter-subunit-E	unknown	unknown	gnl\|CDD\|181598
NZ_AP021867.1\|WP_153676113.1\|4186365_4187841_-\|anthranilate-synthase-component-I	unknown	unknown	gnl\|CDD\|184146
NZ_AP021867.1\|WP_065723597.1\|4199311_4200277_-\|sodium:calcium-antiporter	unknown	unknown	gnl\|CDD\|223604
NZ_AP021867.1\|WP_100435365.1\|4196237_4197773_+\|monovalent-cation/H+-antiporter-subunit-D	unknown	unknown	gnl\|CDD\|237166
NZ_AP021867.1\|WP_006399178.1\|4201129_4201669_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_100435366.1\|4200350_4201004_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_153676112.1\|4185518_4186298_-\|SIMPL-domain-containing-protein	unknown	unknown	gnl\|CDD\|377344
NZ_AP021867.1\|WP_161994219.1\|4191055_4191982_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|237571
NZ_AP021867.1\|WP_100435361.1\|4188122_4189076_-\|lipid-kinase-YegS	unknown	unknown	gnl\|CDD\|237281
NZ_AP021867.1\|WP_006399171.1\|4198272_4198557_+\|K+/H+-antiporter-subunit-F	unknown	unknown	gnl\|CDD\|180435
NZ_AP021867.1\|WP_153676116.1\|4193020_4195849_+\|monovalent-cation/H+-antiporter-subunit-A	unknown	unknown	gnl\|CDD\|237157
NZ_AP021867.1\|WP_005411327.1\|4190584_4190914_-\|DnaJ-domain-containing-protein	unknown	unknown	gnl\|CDD\|236512

Protein	Function_ID	Function_description	E-value
NZ_AP021867.1\|WP_049401666.1\|4183011_4183806_-\|indole-3-glycerol-phosphate-synthase-TrpC	gnl\|CDD\|234710	PRK00278, trpC, indole-3-glycerol phosphate synthase TrpC.	2.74373e-153
NZ_AP021867.1\|WP_100435362.1\|4192201_4192687_+\|DUF962-domain-containing-protein	gnl\|CDD\|226914	COG4539, COG4539, Predicted membrane protein [Function unknown].	3.58008e-15
NZ_AP021867.1\|WP_153676117.1\|4195848_4196241_+\|Na+/H+-antiporter-subunit-C	gnl\|CDD\|236377	PRK09094, PRK09094, putative monovalent cation/H+ antiporter subunit C; Reviewed.	6.27055e-64
NZ_AP021867.1\|WP_006399173.1\|4198553_4198943_+\|Na+/H+-antiporter-subunit-G	gnl\|CDD\|237169	PRK12674, PRK12674, putative monovalent cation/H+ antiporter subunit G; Reviewed.	1.0615e-32
NZ_AP021867.1\|WP_153676114.1\|4189337_4189820_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	3.06752e-15
NZ_AP021867.1\|WP_153676111.1\|4184928_4185516_-\|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	gnl\|CDD\|235552	PRK05670, PRK05670, anthranilate synthase component II; Provisional.	3.90968e-130
NZ_AP021867.1\|WP_046983687.1\|4183880_4184912_-\|anthranilate-phosphoribosyltransferase	gnl\|CDD\|234682	PRK00188, trpD, anthranilate phosphoribosyltransferase; Provisional.	0
NZ_AP021867.1\|WP_006399038.1\|4189879_4190554_-\|ribulose-phosphate-3-epimerase	gnl\|CDD\|136958	PRK08745, PRK08745, ribulose-phosphate 3-epimerase; Provisional.	1.98461e-154
NZ_AP021867.1\|WP_006399169.1\|4197769_4198276_+\|Na+/H+-antiporter-subunit-E	gnl\|CDD\|181598	PRK08965, PRK08965, putative monovalent cation/H+ antiporter subunit E; Reviewed.	2.1253e-61
NZ_AP021867.1\|WP_153676113.1\|4186365_4187841_-\|anthranilate-synthase-component-I	gnl\|CDD\|184146	PRK13565, PRK13565, anthranilate synthase component I; Provisional.	0
NZ_AP021867.1\|WP_065723597.1\|4199311_4200277_-\|sodium:calcium-antiporter	gnl\|CDD\|223604	COG0530, ECM27, Ca2+/Na+ antiporter [Inorganic ion transport and metabolism].	2.69934e-43
NZ_AP021867.1\|WP_100435365.1\|4196237_4197773_+\|monovalent-cation/H+-antiporter-subunit-D	gnl\|CDD\|237166	PRK12666, PRK12666, putative monovalent cation/H+ antiporter subunit D; Reviewed.	0
NZ_AP021867.1\|WP_153676112.1\|4185518_4186298_-\|SIMPL-domain-containing-protein	gnl\|CDD\|377344	pfam04402, SIMPL, Protein of unknown function (DUF541). Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries. However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerization. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.	2.32615e-18
NZ_AP021867.1\|WP_161994219.1\|4191055_4191982_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|237571	PRK13961, PRK13961, phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional.	0
NZ_AP021867.1\|WP_100435361.1\|4188122_4189076_-\|lipid-kinase-YegS	gnl\|CDD\|237281	PRK13054, PRK13054, lipid kinase; Reviewed.	4.3146e-163
NZ_AP021867.1\|WP_006399171.1\|4198272_4198557_+\|K+/H+-antiporter-subunit-F	gnl\|CDD\|180435	PRK06161, PRK06161, putative monovalent cation/H+ antiporter subunit F; Reviewed.	9.48908e-36
NZ_AP021867.1\|WP_153676116.1\|4193020_4195849_+\|monovalent-cation/H+-antiporter-subunit-A	gnl\|CDD\|237157	PRK12648, PRK12648, putative monovalent cation/H+ antiporter subunit A; Reviewed.	0
NZ_AP021867.1\|WP_005411327.1\|4190584_4190914_-\|DnaJ-domain-containing-protein	gnl\|CDD\|236512	PRK09430, djlA, co-chaperone DjlA.	7.85788e-19

>NZ_AP021867.1|WP_161994219.1|4191055_4191982_+|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MPTTLLQSDLPGLPLRHRGKVRDVFDIPRERLPAGTPPGDYLLMVATDRLSAFDVVLPDPIPGKGEMLCQVSNFWFAKTAHLMPNHLTGIDVASVLPEGVDPALYAKRAVVTRKLKPVPVEAIARGYLIGSGWKDYQRTGKVSGIDLPDGLRQAEQLPEPIFTPSTKAAVGDHDENIDFDAMVKQVGAEMAERVRDATLRIYKFAADYARERGIILADTKFEFGTDADGRLYIMDEMLTPDSSRYWPADEYEVGTSPPSYDKQFVRDYLETLDWGKTTPGPAIPAEIIERTRAKYAEALQRLAGISVD
>NZ_AP021867.1|WP_005411327.1|4190584_4190914_-|DnaJ-domain-containing-protein
MRWYGKLLGFIAGALLFRPNPLFGAVVGLLIGHAFDSDWFRLNKENPYRELGLTSEATDAEVERAYRKLISQYHPDKLGGAAPELQQQAEQKSRRINAAYDRIKTLRKR
>NZ_AP021867.1|WP_006399038.1|4189879_4190554_-|ribulose-phosphate-3-epimerase
MSNCLIAPSILSANFARLGEEVDNVLAAGADWVHFDVMDNHYVPNLTIGPMVCQALRKHGVTAPIDVHLMVEPVDRIIPDFAEAGATYISFHPEASRHVHRTIQLIRSLGCKPGIVLNPATPVDILDWVLDDLDLVLLMSVNPGFGGQAFIPSALDKLRVVRKKIDASGRDIRLEIDGGVKADNIGEIAAAGADTFVAGSAIFNAKTSYQDVIAQMRANVAAAR
>NZ_AP021867.1|WP_153676114.1|4189337_4189820_-|GNAT-family-N-acetyltransferase
MALLKIRSATVADAGLILQFIRELAIYEKAEHSVQTDEIGIAESLFGADATASALICEADGEAIGYAVYFYNYSTWLGRKGIYLEDLYVSPQKRGSGAGKALLKYIARQAVAEGCGRFEWSVLDWNTPAIEFYTAVGAKPQDEWTVYRLQGQALHDFANG
>NZ_AP021867.1|WP_100435361.1|4188122_4189076_-|lipid-kinase-YegS
MTTPRWRLILNGKSAGNEELRDAVGHWRGQGVQLDVRVTWEDGDAERYVAEAIDHGVDVIVAAGGDGTLSAVAETLAHREEPADALPSLALIPMGTANDFATAAGIPTEPKAALALIGQATPHAIDLLRVDADGTPWWCANLASGGFGTQVTVETDAGLKKMLGGLAYVITGIAKLGRIEPINARLSGPDFAWQGDFIALGIGNGRQAGGGQQLCPQALIDDGLLDVTVLPELEGEVTATLGQMLKSGTQAALEQLATRARLPWLQVESERPLTLNLDGEPVQARHFRIECVPGRVRMHLPADCPLLGGQGLQGRQG
>NZ_AP021867.1|WP_153676113.1|4186365_4187841_-|anthranilate-synthase-component-I
MNSHAQFLQQAAEGHTHIPVVREVLSDLDTPLSVYLKLADGPNTYLFESVEGGERFGRYSIIGLPARRVYAFHGHTLTVREDGQVVDTRAVADPFAEVEALRSAHSVPKLDGLPGFTGGLVGWFGFECIGYIEPRLAPPAGRDELGTPDILLLDSNELAVFDNLKGRLYLIVHADPRTDGAFEQAQSRLDALTAKLRAPGAGYPAPLNSDVLDESDFVSGFTREGFVDAVQRSKEYIRAGDIFQVVLSQRLSVPFKARPVDVYRALRALNPSPYMYFLDVGDLQVVGSSPEILVRLQDGEVTVRPIAGTRPRGATPELDQALEAELLADPKERAEHLMLIDLGRNDAGRVSKAGTVEVGEQFVIERYSHVMHIVSEVTGQLQPGLSYADVLRATFPAGTVSGAPKIRALEVIRELEPIKRNVYAGSIGYIGWHGDADTAIAIRTAVIKDGRLYVQAGAGIVYDSDPDKEWDETMNKGRALFRAVAQAAKGL
>NZ_AP021867.1|WP_153676112.1|4185518_4186298_-|SIMPL-domain-containing-protein
MKLLSALLWSSLLATMAPSAWAQANTIPSQPHLLVKGEARRVVMPDRFGLQLNIEETDMDADAARRRVQDNVARVLALFKQYKAVEGSVRADNLRIGPATRYEQSRQVFMGTQVSRQLRASFASVKQMQNVLGALKANENVQVSSVAPTYSGEVALRRELKGEAAARTRESAQGLAKAYGTKVRGLYSISDVAPNFAYGIQAGQWPQLGEDGEYLDRISVTGSYAPASAPAPAERESIEAGPITYTENVYAIFLISDGT
>NZ_AP021867.1|WP_153676111.1|4184928_4185516_-|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein
MLWMIDNYDSFTYNLVQYLQTLGAEVKVVRNDAMSVDEIAAQKPERIVISPGPCTPNEAGVSLALIERLGPSTPILGVCLGHQGIGQVYGGTVIRAGNIMHGKTSPIRHEGKGVFAGLPDRYQATRYHSLVVDKHSLPDALEVTAWTENDDGSIEEIMGLRHRQFPVEGVQFHPESILTEHGHALLRNFLQRPAA
>NZ_AP021867.1|WP_046983687.1|4183880_4184912_-|anthranilate-phosphoribosyltransferase
MSFSPQEALQRTIEHREIFFDEMVDLMRQIMRGDVSPMMTAAILTGLRVKKETIDEIAAAATVMREFALAVPVADTTHLVDIVGTGGDGSHTFNISTCAMFVAAAAGARVAKHGNRSVSSKSGSADAVEALGAAIELQPAQVAAAIEQTGIGFMFAPIHHPSMKVVAPVRREMGVRTIFNILGPLTNPASAPSVLMGVFHPDLVGIQARVLRELGTERAMVVWGRDNMDEISLGAGTLVGELRDGKVREYEIHPEDFGIAMSASRNLRVDGPEQSIAMLRAVLDNTPGPALDIVALNAGAALYVAGVASDIGDGLARARAAIANGSARQRLQQYVDTTRALVA
>NZ_AP021867.1|WP_049401666.1|4183011_4183806_-|indole-3-glycerol-phosphate-synthase-TrpC
MSDILQTILARKAEEVAQRRAQRPLEDLQAAVASAPPVRGFVRALQAAVANGDPAVIAEVKKASPSKGVIRPDFRPADIAVSYEFGGASCLSVLTDVDFFQGADAYLQQAREACTLPVLRKDFVIDAYQVYEARVLGADCILLIVAALDDTQLATLSELAMSLGMDVLVEVHDIDELERALQVPAPMIGINNRNLRTFEVSLQTTLDMQKAVPRDRLLVTESGILGPQDVALMRDAGIHSFLVGEAFMRVEEPGEGLRQLFFAA
>NZ_AP021867.1|WP_100435362.1|4192201_4192687_+|DUF962-domain-containing-protein
MQTTTELARPIDRYFASYSDDHRNVINQRIHVVAVPAILWSVVALLWCLPPLITWFQYGIWSAFAMFSAWCFYNKLSRPLGIGMLIQFFVFGCLCRLLEAEIGLHNLFWLAVGVFVVAWIAQFIGHKFEGRKPSFLTDLTYLLIGPAWVMAKFYRKLDWRY
>NZ_AP021867.1|WP_153676116.1|4193020_4195849_+|monovalent-cation/H+-antiporter-subunit-A
MLPSLPLLLALPFLMAVAVAAFPRSSRSTAAWLAALAPLGGLAILAWLTPSVLDGQVVRTMVPWLPQIGLDFTLRLDGLAWMFAGLVLGIGALVVLYARYYLSSQDNAHRFYIYLLLFMGAMLGMVVSGNLLLLMIFWEMTSISSFLLIGFWSHRQDAREGARMALVITGGGGLALLGGVLLIGRIVGSFDLDVVLAAGEQIRASALYPYALFLVLAGIFTKSAQFPFHFWLPHAMAAPTPVSAYLHSATMVKAGVFLLARLHPALAGSDLFFYTVSGIGALTLLIGAWNAIFQHDLKGLLAYSTISHLGLITLLFGLSTPMAVVAGVFHILNHATFKASLFMAAGIIDHETGTRDMRKLGGLRRLMPFTSALAIIASLAMAGIPLLNGFLSKEMLFAEALSAGGTDTMRTAVSIAALLAGVFGVAYSLRFVHDTFFGNGPHGLDRVPHEPPRWMKVPVEILVVICVAVGIAPAVTVAPVLHAAAASILGSAMPEYNLSIWHGFNLPLAMSAAGVVGGVLLYFGLRRLIDLHAVTNTTPGRNVFHHQLDLLSAGAQRLTAGIANGSLQRMLLGLVLVAIVAAAAPYIANPASPEWTRPQPIPLLGWALWLVMMSCAVATLRMYKQRLLAVLLVGGVGLMVALTFVFLSAPDLALTQLLVEMVTLVLMLLGMNYLPAQSGPERPRWRKRRDALIAIVAGAGLGALAYSAMTLPPNTMAGELVARALPEAYGQNVVNVILVDFRGFDTFGEITVFGIAALVVHALLRRTRMAPEQIMPGPPIKLPVPADLAQIMFPLTLTVSIFLFLRGHNAPGGGFIAGLVLAVPLLIQYVIQGTASVESRFGFDYIRCIGMGLLIAILSGSASMLFGVPFLTSGHLDLHLPLIGEVPLASAIGFDIGVYLVVFGGAMLMLSMMATVKPSRTRTARKGEIDLQRRSARTGEMH
>NZ_AP021867.1|WP_153676117.1|4195848_4196241_+|Na+/H+-antiporter-subunit-C
MELALASAIGVLTAIGVYLLLRARSFDVILGMTFLSYATNLLIFAGGRVVLGKAPVLQEGVDSNLGNYTDPLPQALVLTAIVIAFAMTAVSIVLAMRSRSDNHSDHVDAHEPDDDLQDEGVSPRQGEDRA
>NZ_AP021867.1|WP_100435365.1|4196237_4197773_+|monovalent-cation/H+-antiporter-subunit-D
MNHLVILPILVPLLGAALSLFVEHRRYGPKVQRAVAWTSLSALALVVGLLFATTASGDISVYLLGDWPSRLGIALVADRLSAWMLLTTLLLAIPCLLHACSGWDRRAPHFHALFQFQLVGLNGAFLTGDIFNLFVFFEVMLIASYGLLLSGGRGLRMRIGLHYVVFNVTASTLFLIALGLLYASLGSLNMAELSQRIAEVPPAQLTLVKATMGLLLLVFCAKAALMPLYLWLPEAYSRAPAAVAALFAIMTKVGLYAVLRIQMLWFGDDAGAMAGYGRDWLLWAGVATLVLGGLGALAATRLRVLISYLVIVSAATLFIAFSVGTPQVLSAGLYYLPHSSFVAAALFLIADLIRRRRGGASDRKEVIAPMPGKETPAVLFLIAAVSVAGLPPLSGFLAKAALLAGMPAQYTGPVWTAVLVSSLLVIMGLTRGGIRLFWRVPPVDPDAPPPRKARLRRVELYAACILLAYGIGMTLAAAPLMRYTDATAAQLLQPGEYVQQLRATAPEIRQP
>NZ_AP021867.1|WP_006399169.1|4197769_4198276_+|Na+/H+-antiporter-subunit-E
MTAQRSLFRRIIPSPMLSIMVVAFWLLMSDSFTVGQTVLGLVLGVVVPLFAARLDREFARIGTLRPLPKLLCVTLWDILMSNIRVALQVLGPEKNIHPGFIWLPLDIANIHGIAALTSMITLTPGTVSAALSEDRRFLLVHVLHLEDPQALIDTIKRRYEAPLMEIFP
>NZ_AP021867.1|WP_006399171.1|4198272_4198557_+|K+/H+-antiporter-subunit-F
MTGFQIIQTTLVVCMHVVGLAMLLATWRLLRGPTVPDRILALDTLSVTAIAELMLFGMYLNSAIYFEAALVIAMLGFGSTVVLSKFVLRRDIVE
>NZ_AP021867.1|WP_006399173.1|4198553_4198943_+|Na+/H+-antiporter-subunit-G
MITAIQIGLSILLLFGCFFILVGALGLVKLSTFFKRLHAPTKASTLGVGCVLVCSVCYHIFLGQDPQPRELLITVFLFITAPISAHMMAKAALSLLMETRPSLPGNEPAAEEQLPPPEPVREEEGSQGR
>NZ_AP021867.1|WP_065723597.1|4199311_4200277_-|sodium:calcium-antiporter
MIAIAIAWFLLGLLLLALGGDSIVKAVSGLAQRFGASPFTAGLLLLGVTTSLPELAVNARALTVGQPELALGNAVGSSIVNLGLTLAVAAMAAPLLLRARLQTVLWWSLLAAGVVLILFGLDGGLARWEGGVLVAGFIIVQVVLLRRGRSESAEVQAAIAESALSRTSLPLNVLRVVIAALALYWGARLVVGAAADFGVALGWTPLLVGLLPVAIGTALPEVATAIAAARRGHGDMVMGHVLGSSVVNLLLVIGAMAVLQPLALPASFVRLELPALLAFALVLYPMLRGDLKISRGEGAILLVAFLGWFMLELLLVGAPGL
>NZ_AP021867.1|WP_100435366.1|4200350_4201004_-|hypothetical-protein
MKHLPIAGLLLLSLTACGGQDKQGAAGSGSDTPAETAAATGPAQSADPDLASRPANDLRSDSPARLDGYAGAKLGAAIAEVRSGFGTPLQGLGSDAAGKPLPVDDSNDGCYFLRPQNAEDPRLMIEGRKLVRYDVHSAAVIAPGGGKVGMTLGELQVLYPERGDVVPDKYDEKAQHLRVRPAQEGGAVIDFALGADGRVGAWRVGQTPQVDYVEGCG
>NZ_AP021867.1|WP_006399178.1|4201129_4201669_+|hypothetical-protein
MQPRKTDLARTALQAHRAPLDMRQRRLLILCDGQRTIADLTGLLGQDAPAMVIQLVQAGYLSTGPAAPVPSPGPAAGSVAAPPAPAPLPPAATPVERRRSLVAARIYVLGILEMQRHPQAAALFRDLQQARAEDEVLQRLQSAMQMLPGLTSDGYCQRVRQRLLEALPLEHCDAFAEAA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_AP021867_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP021867_14

4198945-4199043

Orphan

Consensus_repeat	Method
CCCGGTAGAGGCCGACCTTGGCCGG	CRISPRCasFinder

1 spacers

PD-DExK

The CRISPR arrays of NZ_AP021867_14

>merge|NZ_AP021867|14|4198945-4199043|CRISPRCasFinder
CCCGGTAGAGGCCGACCTTGGCCGGTACGGAGCCAACCGCATCCACGCATGGCGTGGATCTACCGACCGCAATGCCCGGTAGAGGCCGACCTTGGTCGG

>NZ_AP021867|14|14|4198945-4199043|CRISPRCasFinder
CCCGGTAGAGGCCGACCTTGGCCGG	TACGGAGCCAACCGCATCCACGCATGGCGTGGATCTACCGACCGCAATG
CCCGGTAGAGGCCGACCTTGGTCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP021867.1\|WP_006399180.1\|4201751_4203050_-\|homogentisate-1,2-dioxygenase	unknown	unknown	gnl\|CDD\|235421
NZ_AP021867.1\|WP_081307605.1\|4204314_4204872_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NZ_AP021867.1\|WP_006399182.1\|4203135_4204248_-\|4-hydroxyphenylpyruvate-dioxygenase	unknown	unknown	gnl\|CDD\|225726
NZ_AP021867.1\|WP_100435362.1\|4192201_4192687_+\|DUF962-domain-containing-protein	unknown	unknown	gnl\|CDD\|226914
NZ_AP021867.1\|WP_153676117.1\|4195848_4196241_+\|Na+/H+-antiporter-subunit-C	unknown	unknown	gnl\|CDD\|236377
NZ_AP021867.1\|WP_006399173.1\|4198553_4198943_+\|Na+/H+-antiporter-subunit-G	unknown	unknown	gnl\|CDD\|237169
NZ_AP021867.1\|WP_006399038.1\|4189879_4190554_-\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|136958
NZ_AP021867.1\|WP_012512330.1\|4207483_4208083_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|379399
NZ_AP021867.1\|WP_006399169.1\|4197769_4198276_+\|Na+/H+-antiporter-subunit-E	unknown	unknown	gnl\|CDD\|181598
NZ_AP021867.1\|WP_153676119.1\|4208102_4209602_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|225646
NZ_AP021867.1\|WP_065723597.1\|4199311_4200277_-\|sodium:calcium-antiporter	unknown	unknown	gnl\|CDD\|223604
NZ_AP021867.1\|WP_100435365.1\|4196237_4197773_+\|monovalent-cation/H+-antiporter-subunit-D	unknown	unknown	gnl\|CDD\|237166
NZ_AP021867.1\|WP_006399178.1\|4201129_4201669_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_100435366.1\|4200350_4201004_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_161994219.1\|4191055_4191982_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|237571
NZ_AP021867.1\|WP_012512329.1\|4206091_4207231_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_006399171.1\|4198272_4198557_+\|K+/H+-antiporter-subunit-F	unknown	unknown	gnl\|CDD\|180435
NZ_AP021867.1\|WP_153676116.1\|4193020_4195849_+\|monovalent-cation/H+-antiporter-subunit-A	unknown	unknown	gnl\|CDD\|237157
NZ_AP021867.1\|WP_153676118.1\|4205101_4206073_+\|DUF1016-family-protein	PD-DExK	COG4804_PD-DExK_CAS-I:CAS-III	gnl\|CDD\|377634
NZ_AP021867.1\|WP_005411327.1\|4190584_4190914_-\|DnaJ-domain-containing-protein	unknown	unknown	gnl\|CDD\|236512

Protein	Function_ID	Function_description	E-value
NZ_AP021867.1\|WP_006399180.1\|4201751_4203050_-\|homogentisate-1,2-dioxygenase	gnl\|CDD\|235421	PRK05341, PRK05341, homogentisate 1,2-dioxygenase; Provisional.	0
NZ_AP021867.1\|WP_081307605.1\|4204314_4204872_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	5.63804e-16
NZ_AP021867.1\|WP_006399182.1\|4203135_4204248_-\|4-hydroxyphenylpyruvate-dioxygenase	gnl\|CDD\|225726	COG3185, COG3185, 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only].	2.60674e-154
NZ_AP021867.1\|WP_100435362.1\|4192201_4192687_+\|DUF962-domain-containing-protein	gnl\|CDD\|226914	COG4539, COG4539, Predicted membrane protein [Function unknown].	3.58008e-15
NZ_AP021867.1\|WP_153676117.1\|4195848_4196241_+\|Na+/H+-antiporter-subunit-C	gnl\|CDD\|236377	PRK09094, PRK09094, putative monovalent cation/H+ antiporter subunit C; Reviewed.	6.27055e-64
NZ_AP021867.1\|WP_006399173.1\|4198553_4198943_+\|Na+/H+-antiporter-subunit-G	gnl\|CDD\|237169	PRK12674, PRK12674, putative monovalent cation/H+ antiporter subunit G; Reviewed.	1.0615e-32
NZ_AP021867.1\|WP_006399038.1\|4189879_4190554_-\|ribulose-phosphate-3-epimerase	gnl\|CDD\|136958	PRK08745, PRK08745, ribulose-phosphate 3-epimerase; Provisional.	1.98461e-154
NZ_AP021867.1\|WP_006399169.1\|4197769_4198276_+\|Na+/H+-antiporter-subunit-E	gnl\|CDD\|181598	PRK08965, PRK08965, putative monovalent cation/H+ antiporter subunit E; Reviewed.	2.1253e-61
NZ_AP021867.1\|WP_153676119.1\|4208102_4209602_-\|MFS-transporter	gnl\|CDD\|225646	COG3104, PTR2, Dipeptide/tripeptide permease [Amino acid transport and metabolism].	7.28527e-143
NZ_AP021867.1\|WP_065723597.1\|4199311_4200277_-\|sodium:calcium-antiporter	gnl\|CDD\|223604	COG0530, ECM27, Ca2+/Na+ antiporter [Inorganic ion transport and metabolism].	2.69934e-43
NZ_AP021867.1\|WP_100435365.1\|4196237_4197773_+\|monovalent-cation/H+-antiporter-subunit-D	gnl\|CDD\|237166	PRK12666, PRK12666, putative monovalent cation/H+ antiporter subunit D; Reviewed.	0
NZ_AP021867.1\|WP_161994219.1\|4191055_4191982_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|237571	PRK13961, PRK13961, phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional.	0
NZ_AP021867.1\|WP_012512330.1\|4207483_4208083_-\|thioredoxin-family-protein	gnl\|CDD\|379399	pfam13899, Thioredoxin_7, Thioredoxin-like. Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond.	3.40762e-05
NZ_AP021867.1\|WP_006399171.1\|4198272_4198557_+\|K+/H+-antiporter-subunit-F	gnl\|CDD\|180435	PRK06161, PRK06161, putative monovalent cation/H+ antiporter subunit F; Reviewed.	9.48908e-36
NZ_AP021867.1\|WP_153676116.1\|4193020_4195849_+\|monovalent-cation/H+-antiporter-subunit-A	gnl\|CDD\|237157	PRK12648, PRK12648, putative monovalent cation/H+ antiporter subunit A; Reviewed.	0
NZ_AP021867.1\|WP_153676118.1\|4205101_4206073_+\|DUF1016-family-protein	gnl\|CDD\|377634	pfam06250, DUF1016, Protein of unknown function (DUF1016). Family of uncharacterized proteins found in viruses, archaea and bacteria.	4.82149e-67
NZ_AP021867.1\|WP_005411327.1\|4190584_4190914_-\|DnaJ-domain-containing-protein	gnl\|CDD\|236512	PRK09430, djlA, co-chaperone DjlA.	7.85788e-19

>NZ_AP021867.1|WP_006399173.1|4198553_4198943_+|Na+/H+-antiporter-subunit-G
MITAIQIGLSILLLFGCFFILVGALGLVKLSTFFKRLHAPTKASTLGVGCVLVCSVCYHIFLGQDPQPRELLITVFLFITAPISAHMMAKAALSLLMETRPSLPGNEPAAEEQLPPPEPVREEEGSQGR
>NZ_AP021867.1|WP_006399171.1|4198272_4198557_+|K+/H+-antiporter-subunit-F
MTGFQIIQTTLVVCMHVVGLAMLLATWRLLRGPTVPDRILALDTLSVTAIAELMLFGMYLNSAIYFEAALVIAMLGFGSTVVLSKFVLRRDIVE
>NZ_AP021867.1|WP_006399169.1|4197769_4198276_+|Na+/H+-antiporter-subunit-E
MTAQRSLFRRIIPSPMLSIMVVAFWLLMSDSFTVGQTVLGLVLGVVVPLFAARLDREFARIGTLRPLPKLLCVTLWDILMSNIRVALQVLGPEKNIHPGFIWLPLDIANIHGIAALTSMITLTPGTVSAALSEDRRFLLVHVLHLEDPQALIDTIKRRYEAPLMEIFP
>NZ_AP021867.1|WP_100435365.1|4196237_4197773_+|monovalent-cation/H+-antiporter-subunit-D
MNHLVILPILVPLLGAALSLFVEHRRYGPKVQRAVAWTSLSALALVVGLLFATTASGDISVYLLGDWPSRLGIALVADRLSAWMLLTTLLLAIPCLLHACSGWDRRAPHFHALFQFQLVGLNGAFLTGDIFNLFVFFEVMLIASYGLLLSGGRGLRMRIGLHYVVFNVTASTLFLIALGLLYASLGSLNMAELSQRIAEVPPAQLTLVKATMGLLLLVFCAKAALMPLYLWLPEAYSRAPAAVAALFAIMTKVGLYAVLRIQMLWFGDDAGAMAGYGRDWLLWAGVATLVLGGLGALAATRLRVLISYLVIVSAATLFIAFSVGTPQVLSAGLYYLPHSSFVAAALFLIADLIRRRRGGASDRKEVIAPMPGKETPAVLFLIAAVSVAGLPPLSGFLAKAALLAGMPAQYTGPVWTAVLVSSLLVIMGLTRGGIRLFWRVPPVDPDAPPPRKARLRRVELYAACILLAYGIGMTLAAAPLMRYTDATAAQLLQPGEYVQQLRATAPEIRQP
>NZ_AP021867.1|WP_153676117.1|4195848_4196241_+|Na+/H+-antiporter-subunit-C
MELALASAIGVLTAIGVYLLLRARSFDVILGMTFLSYATNLLIFAGGRVVLGKAPVLQEGVDSNLGNYTDPLPQALVLTAIVIAFAMTAVSIVLAMRSRSDNHSDHVDAHEPDDDLQDEGVSPRQGEDRA
>NZ_AP021867.1|WP_153676116.1|4193020_4195849_+|monovalent-cation/H+-antiporter-subunit-A
MLPSLPLLLALPFLMAVAVAAFPRSSRSTAAWLAALAPLGGLAILAWLTPSVLDGQVVRTMVPWLPQIGLDFTLRLDGLAWMFAGLVLGIGALVVLYARYYLSSQDNAHRFYIYLLLFMGAMLGMVVSGNLLLLMIFWEMTSISSFLLIGFWSHRQDAREGARMALVITGGGGLALLGGVLLIGRIVGSFDLDVVLAAGEQIRASALYPYALFLVLAGIFTKSAQFPFHFWLPHAMAAPTPVSAYLHSATMVKAGVFLLARLHPALAGSDLFFYTVSGIGALTLLIGAWNAIFQHDLKGLLAYSTISHLGLITLLFGLSTPMAVVAGVFHILNHATFKASLFMAAGIIDHETGTRDMRKLGGLRRLMPFTSALAIIASLAMAGIPLLNGFLSKEMLFAEALSAGGTDTMRTAVSIAALLAGVFGVAYSLRFVHDTFFGNGPHGLDRVPHEPPRWMKVPVEILVVICVAVGIAPAVTVAPVLHAAAASILGSAMPEYNLSIWHGFNLPLAMSAAGVVGGVLLYFGLRRLIDLHAVTNTTPGRNVFHHQLDLLSAGAQRLTAGIANGSLQRMLLGLVLVAIVAAAAPYIANPASPEWTRPQPIPLLGWALWLVMMSCAVATLRMYKQRLLAVLLVGGVGLMVALTFVFLSAPDLALTQLLVEMVTLVLMLLGMNYLPAQSGPERPRWRKRRDALIAIVAGAGLGALAYSAMTLPPNTMAGELVARALPEAYGQNVVNVILVDFRGFDTFGEITVFGIAALVVHALLRRTRMAPEQIMPGPPIKLPVPADLAQIMFPLTLTVSIFLFLRGHNAPGGGFIAGLVLAVPLLIQYVIQGTASVESRFGFDYIRCIGMGLLIAILSGSASMLFGVPFLTSGHLDLHLPLIGEVPLASAIGFDIGVYLVVFGGAMLMLSMMATVKPSRTRTARKGEIDLQRRSARTGEMH
>NZ_AP021867.1|WP_100435362.1|4192201_4192687_+|DUF962-domain-containing-protein
MQTTTELARPIDRYFASYSDDHRNVINQRIHVVAVPAILWSVVALLWCLPPLITWFQYGIWSAFAMFSAWCFYNKLSRPLGIGMLIQFFVFGCLCRLLEAEIGLHNLFWLAVGVFVVAWIAQFIGHKFEGRKPSFLTDLTYLLIGPAWVMAKFYRKLDWRY
>NZ_AP021867.1|WP_161994219.1|4191055_4191982_+|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MPTTLLQSDLPGLPLRHRGKVRDVFDIPRERLPAGTPPGDYLLMVATDRLSAFDVVLPDPIPGKGEMLCQVSNFWFAKTAHLMPNHLTGIDVASVLPEGVDPALYAKRAVVTRKLKPVPVEAIARGYLIGSGWKDYQRTGKVSGIDLPDGLRQAEQLPEPIFTPSTKAAVGDHDENIDFDAMVKQVGAEMAERVRDATLRIYKFAADYARERGIILADTKFEFGTDADGRLYIMDEMLTPDSSRYWPADEYEVGTSPPSYDKQFVRDYLETLDWGKTTPGPAIPAEIIERTRAKYAEALQRLAGISVD
>NZ_AP021867.1|WP_005411327.1|4190584_4190914_-|DnaJ-domain-containing-protein
MRWYGKLLGFIAGALLFRPNPLFGAVVGLLIGHAFDSDWFRLNKENPYRELGLTSEATDAEVERAYRKLISQYHPDKLGGAAPELQQQAEQKSRRINAAYDRIKTLRKR
>NZ_AP021867.1|WP_006399038.1|4189879_4190554_-|ribulose-phosphate-3-epimerase
MSNCLIAPSILSANFARLGEEVDNVLAAGADWVHFDVMDNHYVPNLTIGPMVCQALRKHGVTAPIDVHLMVEPVDRIIPDFAEAGATYISFHPEASRHVHRTIQLIRSLGCKPGIVLNPATPVDILDWVLDDLDLVLLMSVNPGFGGQAFIPSALDKLRVVRKKIDASGRDIRLEIDGGVKADNIGEIAAAGADTFVAGSAIFNAKTSYQDVIAQMRANVAAAR
>NZ_AP021867.1|WP_065723597.1|4199311_4200277_-|sodium:calcium-antiporter
MIAIAIAWFLLGLLLLALGGDSIVKAVSGLAQRFGASPFTAGLLLLGVTTSLPELAVNARALTVGQPELALGNAVGSSIVNLGLTLAVAAMAAPLLLRARLQTVLWWSLLAAGVVLILFGLDGGLARWEGGVLVAGFIIVQVVLLRRGRSESAEVQAAIAESALSRTSLPLNVLRVVIAALALYWGARLVVGAAADFGVALGWTPLLVGLLPVAIGTALPEVATAIAAARRGHGDMVMGHVLGSSVVNLLLVIGAMAVLQPLALPASFVRLELPALLAFALVLYPMLRGDLKISRGEGAILLVAFLGWFMLELLLVGAPGL
>NZ_AP021867.1|WP_100435366.1|4200350_4201004_-|hypothetical-protein
MKHLPIAGLLLLSLTACGGQDKQGAAGSGSDTPAETAAATGPAQSADPDLASRPANDLRSDSPARLDGYAGAKLGAAIAEVRSGFGTPLQGLGSDAAGKPLPVDDSNDGCYFLRPQNAEDPRLMIEGRKLVRYDVHSAAVIAPGGGKVGMTLGELQVLYPERGDVVPDKYDEKAQHLRVRPAQEGGAVIDFALGADGRVGAWRVGQTPQVDYVEGCG
>NZ_AP021867.1|WP_006399178.1|4201129_4201669_+|hypothetical-protein
MQPRKTDLARTALQAHRAPLDMRQRRLLILCDGQRTIADLTGLLGQDAPAMVIQLVQAGYLSTGPAAPVPSPGPAAGSVAAPPAPAPLPPAATPVERRRSLVAARIYVLGILEMQRHPQAAALFRDLQQARAEDEVLQRLQSAMQMLPGLTSDGYCQRVRQRLLEALPLEHCDAFAEAA
>NZ_AP021867.1|WP_006399180.1|4201751_4203050_-|homogentisate-1,2-dioxygenase
MSPAITARGYQSGFGNEFATEAVAGALPVGQNSPQKVAHGLYAEQLTGTAFTAPRGSNRRSWLYRIRPAVTHGEFTPFAQSQLQCDFAAQPASPNQLRWSPLPLPELPTDFVEGLYTMGGNGSPDAHSGVGIHLYAANRDMVGRYFYDADGELLIVPQLGALRLLTELGVIEIEPQQIAVIPRGVRFRVELPDGPSRGYICENYGALLKLPDLGPIGSNGLANPRDFETPHAAFEDVDGDFELIAKFEGRLWRAPIDHSPLDVVAWHGNYAPYRYDLRRFNTIGSISHDHPDPSIFLVLHSPSDTPGTSNMDFAIFPPRWLVAQNTFRPPWFHRNIASEFMGLVHGAYDAKAEGFVPGGASLHNCMSGHGPDAPTFDKASNADLSKPDVIKDTMAFMFETRAVIRPTAQALAAGHRQGDYQQCWNGLRNNYR
>NZ_AP021867.1|WP_006399182.1|4203135_4204248_-|4-hydroxyphenylpyruvate-dioxygenase
MNTAVPTASHPNPGMQVTTFENPMGIDGFEFVEFAAPAGRGQELHEYFRKMGFSAVLKHKQRPITVYRQGDVNFLVNEDPDSFAADFAEKHGPCACGFAIRFKKPGQEVYQTALGNGAEAIAFKPDSKAVNAPVIKGIGDCMLYLVDRYGSAGSIFDGDYELIAGAELRPKGFGLTFIDHLTHNLYFGNMQQWSDYYERLFNFREIRYFDIKGLKTGLVSKAMTAPDGIVRIPLNESSDPKSQINEYLDAYKGEGIQHIACFTENIYETVEAMRAQGVDFLDTPETYFDVIDQRVPNHGEDVARLAKNKILIDADPETHQRKLLQIFTQNCIGPIFFEIIQRKGNEGFGEGNFTALFESIERDQIRRGVL
>NZ_AP021867.1|WP_081307605.1|4204314_4204872_+|winged-helix-turn-helix-transcriptional-regulator
MQGLDLPLIVTLETTSKVHRNMSPADPVSTRLRSSHVLLDLEQFLPYRLSVLSNRVSGNIAKLYGDRYGLAIPEWRVITILALYPGSSASEVSDRTAMDKVAVSRAVARLLERGFIKRETHGDDRRRSVLALSAAGFEVYETIAPMVIEITRKLMSVLSEEEEQVLEKLILRLAGDGLERMGEGV
>NZ_AP021867.1|WP_153676118.1|4205101_4206073_+|DUF1016-family-protein
MHRTINAELTLLYWRIGRRIQVDQMAGQRARYGELLFTRIAKALSAEFGTSFGEKSLRRMVQFSIAFADEQIVVSLIRQLSWTHFIALIPLADPLKRDFYAQMAGTVGWSVRTLRQRIDSMLYERTALSSQPEQTIADELAALRGNQQLSPGLVLRDPYVLDFLGLKDSLDEQDLESAILREMQGFLLELGTGFSFVARQKRIQIDGDDFHLDLLFYNRRLRRLIAIELKIGEFKPAYKGQMELYLRWLDRHEREDGEQAPLGIILCTGKKAGQIELLELDRSGIHVAEYLTTLPSREVLKQRLQTAMERARQQMENLPPSPL
>NZ_AP021867.1|WP_012512329.1|4206091_4207231_-|hypothetical-protein
MHSDHAERLPEPASALAEGGADEGVTLPPQEALLDDAGTGGDTVELAPPRHRLPQIALPDNVVLKGAVQKLVEQKSRLDALAAEGQLAGLLPPEWQGHGVRAIELSTFIQGVLPFLQPGERGETAPARLPVRHVLGDDSRWGLDDVSEPKSLAWYLASDERATAGSKDVAEAYLVGALGLAWMQEGRSRPGFLRAMGQDSLAARVTMLGYPPAGELALYSVTAHGQPQIWCVHGRRRMRPLVAPWLSVPLLTAYGVPAPVAWPSSFPPVEAVAELLATARQGRALPEVDLGKVVAKIAEDAASDAWQPVSLLQLNTWSPRWHFFLGTFVGLPSLLLVAAALALPGAVEAATVAASLGFAGGAIAALAVPWIHARRKHLS
>NZ_AP021867.1|WP_012512330.1|4207483_4208083_-|thioredoxin-family-protein
MRSKLGGAMVVVCAALIGACSQPQPPAVAEPTQPLDTRPTEPPVADPSEPVASGNTPVAADIAAIAGLGAQFDPARDPANDLATAKVEAQRGKKRILLEVGNAACERCHALDELVEGNGDLRRFRDAHYVWVKVNASDEQPNTAFFAQFPMMERDYPYLLVLDADGGLLVSQATGELRKGETFQPARVTAFLKQWAPDR
>NZ_AP021867.1|WP_153676119.1|4208102_4209602_-|MFS-transporter
MSLNATANTPEPAVPDFKTMMGHPRPLWMLFMTEFWERFAFYGIRWALVLYIVAQFRDGSAAGEADASRIYGAYLALVYAAAIFGGYVADRVLGYQRSILTGAVIMAAGLFMISLPEEHLFKLGLATIIVGNGMFKPNISTMVGKLYGLKDERRDSGFTIFYMGINIGAMIAPVLTEYLARKVFGTSEMPSYKVVFIASGVGMLISLVWFYVGRAGLKGIGAPPAGAEGFGRVVMVLAGAVVAIPVAYFLLATGATALAWILGAMFTALAILLLVEGIREGKVQRDRVIAMLIIFAFNVMFWMFFEQAGSSFTFLAENIVNRQMGEWTFPTAWFQSVNSVAIITLAPIIAWIWVALGRANPSIPRKFGLGLLFNGAAFALLMYALSQMVVDGKIPFWTLFMVYVIQSVGELCLSPIGLSMVTKLAPVRLVGFGMGGWFLSTGIGNNLSGIFAGVVSGEGGMTVESALKGYTFGFWALIGSGVVLFLVAPLINKLMHGVK

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_AP021867_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP021867_15

4260434-4260535

Orphan

Consensus_repeat	Method
GCCAACCAAGGTTGGCAACTACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP021867_15

>merge|NZ_AP021867|15|4260434-4260535|CRISPRCasFinder
GCCAACCAAGGTTGGCAACTACCTGGGCAGAGGGAGCCTGGTAGAGGCCGACCTTGGTCGGCGCATACGGTGTGCGTGCGCCAACCAAGGTTGGCACCTACC

>NZ_AP021867|15|15|4260434-4260535|CRISPRCasFinder
GCCAACCAAGGTTGGCAACTACC	TGGGCAGAGGGAGCCTGGTAGAGGCCGACCTTGGTCGGCGCATACGGTGTGCGTGC
GCCAACCAAGGTTGGCACCTACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP021867.1\|WP_100469848.1\|4268660_4270637_-\|cytochrome-o-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|131890
NZ_AP021867.1\|WP_032127113.1\|4254383_4254692_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_006399830.1\|4267694_4268027_-\|cytochrome-o-ubiquinol-oxidase-subunit-IV	unknown	unknown	gnl\|CDD\|131894
NZ_AP021867.1\|WP_153676246.1\|4266879_4267551_-\|SCO-family-protein	unknown	unknown	gnl\|CDD\|239266
NZ_AP021867.1\|WP_006399785.1\|4266159_4266753_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_100469836.1\|4255619_4257119_+\|YifB-family-Mg-chelatase-like-AAA-ATPase	unknown	unknown	gnl\|CDD\|223679
NZ_AP021867.1\|WP_049400816.1\|4255139_4255490_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_AP021867.1\|WP_153676137.1\|4257794_4260113_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NZ_AP021867.1\|WP_153676138.1\|4260554_4261388_-\|sugar-phosphatase	unknown	unknown	gnl\|CDD\|182509
NZ_AP021867.1\|WP_153676136.1\|4257287_4257674_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_100470165.1\|4248798_4250040_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|274576
NZ_AP021867.1\|WP_032973517.1\|4251360_4252134_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379276
NZ_AP021867.1\|WP_161994220.1\|4252123_4252891_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_153676139.1\|4264393_4266160_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173789
NZ_AP021867.1\|WP_012512368.1\|4263642_4264083_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226695
NZ_AP021867.1\|WP_100469843.1\|4262339_4263650_-\|sorbosone-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|225044
NZ_AP021867.1\|WP_012512371.1\|4268028_4268664_-\|cytochrome-o-ubiquinol-oxidase-subunit-III	unknown	unknown	gnl\|CDD\|131889
NZ_AP021867.1\|WP_100469831.1\|4250042_4251350_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|274576
NZ_AP021867.1\|WP_152905172.1\|4252965_4254213_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_012512366.1\|4261537_4262200_+\|exopolysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|368723

Protein	Function_ID	Function_description	E-value
NZ_AP021867.1\|WP_100469848.1\|4268660_4270637_-\|cytochrome-o-ubiquinol-oxidase-subunit-I	gnl\|CDD\|131890	TIGR02843, Cytochrome_bo3_ubiquinol_oxidase_subunit_1, cytochrome o ubiquinol oxidase, subunit I. Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain which reacts with oxygen, reducing it to water with the concomitant transport of 4 protons across the membrane. Also known as the cytochrome bo complex, cytochrome o ubiquinol oxidase contains four subunits, two heme b cofactors and a copper atom which is believed to be the oxygen active site. This complex is structurally related to the cytochrome caa3 oxidases which utilize cytochrome c as the reductant and contain heme a cofactors, as well as the intermediate form aa3 oxidases which also react directly with quinones as the reductant. [Energy metabolism, Electron transport].	0
NZ_AP021867.1\|WP_100470165.1\|4248798_4250040_-\|ABC-transporter-permease	gnl\|CDD\|274576	TIGR03434, ADOP, Acidobacterial duplicated orphan permease. Members of this protein family are found, so far, only in three species of Acidobacteria, namely Acidobacteria bacterium Ellin345, Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus Ellin6076, where they form large paralogous families. Each protein contains two copies of a domain called the efflux ABC transporter permease protein (pfam02687). However, unlike other members of that family (including LolC, FtsX, and MacB), genes for these proteins are essentially never found fused or adjacent to ABC transporter ATP-binding protein (pfam00005) genes. We name this family ADOP, for Acidobacterial Duplicated Orphan Permease, to reflect the restricted lineage, internal duplication, lack of associated ATP-binding cassette proteins, and permease homology. The function is unknown.	5.31594e-38
NZ_AP021867.1\|WP_006399830.1\|4267694_4268027_-\|cytochrome-o-ubiquinol-oxidase-subunit-IV	gnl\|CDD\|131894	TIGR02847, Cytochrome_bo3_ubiquinol_oxidase_subunit_4, cytochrome o ubiquinol oxidase subunit IV. Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain which reacts with oxygen, reducing it to water with the concomitant transport of 4 protons across the membrane. Also known as the cytochrome bo complex, cytochrome o ubiquinol oxidase contains four subunits, two heme b cofactors and a copper atom which is believed to be the oxygen active site. This complex is structurally related to the cytochrome caa3 oxidases which utilize cytochrome c as the reductant and contain heme a cofactors, as well as the intermediate form aa3 oxidases which also react directly with quinones as the reductant. [Energy metabolism, Electron transport].	2.63023e-34
NZ_AP021867.1\|WP_153676246.1\|4266879_4267551_-\|SCO-family-protein	gnl\|CDD\|239266	cd02968, SCO, SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c oxidase (COX). They contain a metal binding motif, typically CXXXC, which is located in a flexible loop. COX, the terminal enzyme in the respiratory chain, is imbedded in the inner mitochondrial membrane of all eukaryotes and in the plasma membrane of some prokaryotes. It is composed of two subunits, COX I and COX II. It has been proposed that Sco1 specifically delivers copper to the CuA site, a dinuclear copper center, of the COX II subunit. Mutations in human Sco1 and Sco2 cause fatal infantile hepatoencephalomyopathy and cardioencephalomyopathy, respectively. Both disorders are associated with severe COX deficiency in affected tissues. More recently, it has been argued that the redox sensitivity of the copper binding properties of Sco1 implies that it participates in signaling events rather than functioning as a chaperone that transfers copper to COX II.	1.50023e-50
NZ_AP021867.1\|WP_012512371.1\|4268028_4268664_-\|cytochrome-o-ubiquinol-oxidase-subunit-III	gnl\|CDD\|131889	TIGR02842, Cytochrome_bo3_ubiquinol_oxidase_subunit_3, cytochrome o ubiquinol oxidase, subunit III. Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain which reacts with oxygen, reducing it to water with the concomitant transport of 4 protons across the membrane. Also known as the cytochrome bo complex, cytochrome o ubiquinol oxidase contains four subunits, two heme b cofactors and a copper atom which is believed to be the oxygen active site. This complex is structurally related to the cytochrome caa3 oxidases which utilize cytochrome c as the reductant and contain heme a cofactors, as well as the intermediate form aa3 oxidases which also react directly with quinones as the reductant. [Energy metabolism, Electron transport].	6.70296e-100
NZ_AP021867.1\|WP_100469831.1\|4250042_4251350_-\|ABC-transporter-permease	gnl\|CDD\|274576	TIGR03434, ADOP, Acidobacterial duplicated orphan permease. Members of this protein family are found, so far, only in three species of Acidobacteria, namely Acidobacteria bacterium Ellin345, Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus Ellin6076, where they form large paralogous families. Each protein contains two copies of a domain called the efflux ABC transporter permease protein (pfam02687). However, unlike other members of that family (including LolC, FtsX, and MacB), genes for these proteins are essentially never found fused or adjacent to ABC transporter ATP-binding protein (pfam00005) genes. We name this family ADOP, for Acidobacterial Duplicated Orphan Permease, to reflect the restricted lineage, internal duplication, lack of associated ATP-binding cassette proteins, and permease homology. The function is unknown.	3.84218e-42
NZ_AP021867.1\|WP_049400816.1\|4255139_4255490_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	5.13149e-10
NZ_AP021867.1\|WP_153676139.1\|4264393_4266160_+\|S8-family-serine-peptidase	gnl\|CDD\|173789	cd04059, Peptidases_S8_Protein_convertases_Kexins_Furin-like, Peptidase S8 family domain in Protein convertases. Protein convertases, whose members include furins and kexins, are members of the peptidase S8 or Subtilase clan of proteases. They have an Asp/His/Ser catalytic triad that is not homologous to trypsin. Kexins are involved in the activation of peptide hormones, growth factors, and viral proteins. Furin cleaves cell surface vasoactive peptides and proteins involved in cardiovascular tissue remodeling in the TGN, at cell surface, or in endosomes but rarely in the ER. Furin also plays a key role in blood pressure regulation though the activation of transforming growth factor (TGF)-beta. High specificity is seen for cleavage after dibasic (Lys-Arg or Arg-Arg) or multiple basic residues in protein convertases. There is also strong sequence conservation.	3.7709e-103
NZ_AP021867.1\|WP_153676138.1\|4260554_4261388_-\|sugar-phosphatase	gnl\|CDD\|182509	PRK10513, PRK10513, sugar phosphate phosphatase; Provisional.	2.30661e-175
NZ_AP021867.1\|WP_100469843.1\|4262339_4263650_-\|sorbosone-dehydrogenase-family-protein	gnl\|CDD\|225044	COG2133, COG2133, Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism].	1.11593e-94
NZ_AP021867.1\|WP_153676137.1\|4257794_4260113_-\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	1.50521e-22
NZ_AP021867.1\|WP_012512368.1\|4263642_4264083_-\|hypothetical-protein	gnl\|CDD\|226695	COG4244, COG4244, Predicted membrane protein [Function unknown].	7.95531e-12
NZ_AP021867.1\|WP_032973517.1\|4251360_4252134_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379276	pfam13578, Methyltransf_24, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.04374e-09
NZ_AP021867.1\|WP_100469836.1\|4255619_4257119_+\|YifB-family-Mg-chelatase-like-AAA-ATPase	gnl\|CDD\|223679	COG0606, COG0606, Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones].	0
NZ_AP021867.1\|WP_012512366.1\|4261537_4262200_+\|exopolysaccharide-biosynthesis-protein	gnl\|CDD\|368723	pfam06055, ExoD, Exopolysaccharide synthesis, ExoD. Among the bacterial genes required for nodule invasion are the exo genes. These genes are involved in the production of an extracellular polysaccharide. Mutations in the exoD result in altered exopolysaccharide production and defects in nodule invasion.	4.49124e-43

>NZ_AP021867.1|WP_153676137.1|4257794_4260113_-|TonB-dependent-receptor
MNTPPTTRLALAIITAIAAPAYAAETHDAAHDTPTTLNALQVIATPRGAAVAPTQVVGPNRYIIKAEDLDAMVTGNNGLAMLKQVPGASYTATDGLGLDISATSLFVRGFRMNEMGITFEGVPLNDSGFLSLTGTSVVNVGVPDGIGAITVSPGGAPVSVFSSSVNGGSLEYRLRELQDTPSLRVKQGVGSNSTLVTTVSGQSGQLGEHGPKVLVDLQRVSADKYQGEGTQNFLRGDLKLQQDVAWGDFTLFLSDSKAKVWGYNNISFDMIRKLGWKADIFYPDYAWAWYVASPENADKSCGPYTCGELSELIPYDTGQITRDRVSSINHRFQITPALSGNVQLYNANSHTQATLTDPTVPSPNGAPFSEQVQTPRVNRLGGMLNLQFETGAHTFTAGFWQEKSKAAAKTEWYQQPLLGEGPPLKATGPFDVYGPAFKTDNASSWVTRSRQFYLQDDIVLNDTLKLGVGFKAVDFRTSGGGLGDAKDRPVNGTLRAKSNFLPHVSLFWSPTESTDAFIDLANTMNGYRVAQRGNIGYTASAWTITDQEEFDRVAGTLRPEKNWNLTVGASHRFDRLTITGDVFYNDIRNRLLSAAIGTQFAQINTVRLMPKMHVIGADLGITADLTDHLQFYQGVAVARSYYDSDFVVGDTVYPIKGNAQPGYPQISLVSDLSAHFGDWRFGATSTSYLRQPFTYENDIRVPTFWQVNTYAAYRFGADSAVPGLELRLDVSNLFNRHNIGTATIAGSSFSGDYQTLQRSAPRQLMFSTSMAF
>NZ_AP021867.1|WP_153676136.1|4257287_4257674_-|hypothetical-protein
MLLGHPVYMAQYNPRSPLFDIRSPGRPRQALSVAPVIDLQAEYQFWHVYERVVRPLPGGGLPQAWLVCQKVYRDRWQHPEDSEAAGLSRVLFGDNMTADRASELAELHALVSRRVALLARRGRVDSAA
>NZ_AP021867.1|WP_100469836.1|4255619_4257119_+|YifB-family-Mg-chelatase-like-AAA-ATPase
MSLALVHSRARAGVDAPLVRVEVHLSGGLPVTQIVGLAETSVRESRERVRAALLCARFDFPQRRITLNLAPADLPKEGGRYDLAIALGILAASGQVDPQSLLQYEFLGELGLTGELRPVAGALPAAIAAAEAGRILVVPPGNAAEAALAEHADVRVARTLLECCAGLGNPRLLPPVERVDTTPLPLPDLADVRGQAHARRALEVAAAGGHHLLLIGSPGCGKTLLASRLPSLLPDTEEAEALQLAAIASVSGEGLDPRRWRQRPFRAPHHSASAAALVGGGNPPCPGEISLAHHGVLFLDELPEWNRSALETLREPLESGHIRIARAARSVQYPARFQLVAAMNPCPCGWAGDRSNRCLCSDERINRYRARVSGPLLDRIDLHISVARMDAVELRESTPLGESSAAVRARVEATHARQQARGALNAHLPPAALRACTKLSEADQDLLEQAIERLQLSARAMHRILRVARTIADLAGCETIQTAHLAEAIGYRQLDRGKP
>NZ_AP021867.1|WP_049400816.1|4255139_4255490_+|helix-turn-helix-transcriptional-regulator
MEFRTDSLSARIRVARISNGLSQTDLAKALNVNRATVGHWERELGFVPSIDHLHALSRVTCVSVSWLITGNTIADGGKPEGMRLQMEAHMLTASRNLPISLLDNIVELMRSAERHI
>NZ_AP021867.1|WP_032127113.1|4254383_4254692_-|hypothetical-protein
MTQRTAVKTLSSLTLIIAGVAAAGSASAAASNGDFANDIAASTSIQADMQSLSISEFRDEKSALLADGHHHSDSFGSHHHHDTASKQMAFASRIAADSRFDV
>NZ_AP021867.1|WP_152905172.1|4252965_4254213_-|hypothetical-protein
MSSMAQAQPPDVKNPICLMEIADATESMESVVEGILWSRLRRMRARLQEVLADQQYGAMARVMHQMYQSIGADHQARVLLSSEFCEQYLCLESARKGRLEAGADEQERAEEQARALGALHDIIAREKSIAELAQGRTGRYLREARQWQLYSPVGDCVAEKDATGVWTLRQLPKLGDCIALDLESPPARHHEPRSGVLSQPCLPLTDAEREHVSRKLSDALAAIDSAEPMYGLLIRNFVRRITVRKSADVTSDEAGRYGSEHVPRQPGSIRLLNTHNPELLVEACMESIMHESTHNYLAAWELANGFFVANDYQHRVVSPWSGNPIPNSSYIHAVFVYYVCHRLLKRHLEVSPDLGETAKRHVQRRLAVCAAGFLIEQDLSGRLMTKDAINSEVGQMIDRMQAEMKRQYRYGEWQQ
>NZ_AP021867.1|WP_161994220.1|4252123_4252891_-|hypothetical-protein
MHIDELIPVMEGQPWPEVLRLSPGAHLERLFRGANVVNRVFSLAGTQIEQFLAERGVDARWFHIRLQPLLALGVSLCHDTGTRGVSRCLAPLNVQWFELERALPGANTPDFAYSFGYEEPDLSRIEDPMQKSVWSLFDWRQERQLDDEERRRHQFHVSRPKGVPVVAWFLGRDYNGIHFPRESVEVDGGVCERLTRAAARAFRSEAGEMLLYVADEAVTFHAFSPYLRSVAADAAVRDALDAWLLAGNAGGANAA
>NZ_AP021867.1|WP_032973517.1|4251360_4252134_-|class-I-SAM-dependent-methyltransferase
MLLERLSTLRESMGWVYGSEDLCVLLYCLVKRMRPSTVVELGTGFGVTAAWMAGALRENGAGVIHTYDNGSHFFSEPGSRFVEGLQGPLADSLREMRQDYPAFLNYLFQWAGVDGHVVANWREIGFAEIAQAPAFDGGIDMVFSDFNHSQDSIQALLAAFLPRMAESASIFIDSASTQRLSYLTLEAVVEALNQNKIPRALIKDRSEKDIEAIVRIVQRSRFRLMHLLEARDRAQNSTAWISIEPVDVIPTAATFLH
>NZ_AP021867.1|WP_100469831.1|4250042_4251350_-|ABC-transporter-permease
MFGYYFALARTRLLETKGMSAALILALGLGIGASMTMLTVVRTMTWDPLPGRSEHLYHPFIDALPTSYEVRPGMDPRVALTWVDAQNLLQQAPASHQTALASARLLVDAQRSVQIPFFTQGQYVTADAFAMFGIPVVQGRAWTREDDAAHARVVVLSQDLAARLGSEALVGTTVLLGGQAFTVVGVAGPWSPRPRFYTDLQQDVFKGREDFFIPIGVAAEMQMTVSSSVFSWSGDKPLNRLRDARTSWIQFWAELPDAASVEQYERFVGNYARAQRQAGRFDRATTPRMVSLKDFLVEHRIIPNEVKLQLALCLGFLIVCLLNMSALIFARFIRRSHEISVRRALGARRQDVIYQLCTEALIIGGLGGAVGLIVAEAGLYLVRMQPEDYASLASMDLSMAVLTVGLACVSSVVAAFFPALRATSGRLAMQIKVSE
>NZ_AP021867.1|WP_100470165.1|4248798_4250040_-|ABC-transporter-permease
MAEIPLIVRALARNRFIASILLVQVLVATACVTNLAFLLSERLGTLTYKTGLEEANLGVIETEYLGPAAANPSASIRTDLEAIRQQPGVEQVVAAESLPLSQRSWSVGFTNKVLEGNDISGIVEAEPTVYTASSPAAEVLGLTLVAGRDLSATAFVPMEASADYAGLYKVSEAVVSQALADRLFPQGGAVGKFLYADAQHPIQVVGVVKTLSRPVLKTDADNDMSLILPLIPDGPRVMFAIRAADGRVADVIASSEATLSKRDANRTISRSTSFRELRADYFRHDQTMAIMFLSSGLALLVVTATGVYGLASFWVRKRYRQIGIRRALGARKSDILRYFLVENLILTATGSVVGTALAIGLNMAVARYYEVARIEAPFLAIGVLTVLLLGQAAAYVPARRAAKEAPVAILRSA
>NZ_AP021867.1|WP_153676138.1|4260554_4261388_-|sugar-phosphatase
MDMGRRQSTIELVAIDMDGTLLDPTHTLTVRAKQAIAQARALGVHIVLTSGRPVPGLAPFLHELDIAGDDDYCIACNGGLVQRIGTRETVVEYPLSFDDFLFCEQVAREVGVHFQALDSQRMYTPNQDISYYTVADSHLSRMPLSYRRVADMDPSMSFIKLMMIDEPDVLDAAIARLPTELTERFAVLKSAPFFLEVFDHRAGKGPSLQKLAEHLGIDRANVMAIGDQENDLTMLQYAGTSVAMGNAIDAVKAVAGFETTSNADEGVARAIERFVLQ
>NZ_AP021867.1|WP_012512366.1|4261537_4262200_+|exopolysaccharide-biosynthesis-protein
MTYRAPETNDSAPLAEQIEQMIDELPGDQVSVGTLLSALGDEGLLLIVILLSAIFIIPVSIPGLSTVFGASILLIGLSRVRNRPLWVPQKLARREIATDKLKANLGRALKWVHRMERLSRPMRLAVMVRSKKMMRLNNLMLVFATLLLMAPAGPIPFSNTLPALALMSFAIGFIQRDGAAVAAGYGFVVATVVYFGVLLGGVGFAAESVFSGFRAAPSEM
>NZ_AP021867.1|WP_100469843.1|4262339_4263650_-|sorbosone-dehydrogenase-family-protein
MAKHILPTVGALALVVMLSACAGKAEYHPTDQSGAKPPLPAPKNFLMPPMQVPKGVGWADGQSPTVAEGLKIERIAANLQHPRRLLTLPNGDVLVVEGNGPGEEPVTTPKQWIAGKVKARSGKAGKGGNRVTLLRRTPGTNTWTQHVYIEGLHSPFGIQLIGDTLYVANTGNIMQYHYVPGETRMSDKGREFTDLPSTINHHWTKELLASRDGSKLYVGVGSNSNITENGLAVEYRRAVVLEVDVATRGSRIYASGIRNPTGLDWEPSTGTLWAVANERDEIGADLVPDYLTSVKEDGFYGWPYSYYGQHVDERVQPQRPDLVAKAITPDYAIGSHVAPLGLLFYTGQALPAQYHGGAFIGEHGSWDRSPLSGYEVVYVPFKDGKPIGRPQTVVSGFASKDEKTLMGAPVGMAMDAEGALLVADDVGDVVWRVSAK
>NZ_AP021867.1|WP_012512368.1|4263642_4264083_-|hypothetical-protein
MVNPLAQAHRGLGTTLFSLLNPIPFGFFVGALIFDAIYLNSAEVMWGKSAAWLITFGLLIAIIPRLINLFAVWRRNGTATRIDRIDFFLNLVAVLLAIWNAFVHSRDAYAVAVPGTILSALTVALIALGLILLSLQPPVLQGGRHG
>NZ_AP021867.1|WP_153676139.1|4264393_4266160_+|S8-family-serine-peptidase
MKRHTQRSAPPRSARLALATALVLGSLAVTAQAQQADPLAGRQWHLLNTGQAVLGDTLPVAGNDLNVDGLFRNGIRGQGVTIAIVDDGLQIAHPDLAANVAAVAGKNFANQSNNPSPSNPDRDNHGTMVGGIAGAVGANNLGVRGVAPAATLKGFNFLASNAQGNSNSNIEYSWWDGAEVADVGVFNNSWGSSPGNPNLPLAYSQNDIAAYEQAMSGTRGGRGGIYVKAAGNNHNNGARSDGTDICSADTKNRNTGCIPAGRDPRNNLFNVITVAAVRADGVRSSYSSTGSALWVSGFGGENGWQRQVVPGQLAIRYDPAILTTDVTGCAQGSNKNTSLRNTLDGDQSAIDSTCNYTGKMNGTSAATPMVSGVAALLLETNPNLSYRDVKYILATTATRTDPNRAAVTHSDGRVLVPGWTVNAAGRAYSNWYGFGVVNAARAVQVAEDFQPLGALVDSGWRNTTRTVAIGNTSAAAARLTFQLANGARNIESVQLGFRVNHSNTRQLQFVLISPSGTRSVVQPAFTAIGSGLNGVQRNFTNWDLLSSNAFLDENATGTWTLEVTDLGQAANAASRGNLEFFKIRVLGH
>NZ_AP021867.1|WP_006399785.1|4266159_4266753_+|hypothetical-protein
MMKTTILLSTLALAAMTTTAWAQSSGQTPPAKTLSTVDTQQLKAEATGRSFNVGGSRFQLAPSATVQQASGGQFRITTGADASAAAVGTRSKRSTDASTGVAARADAGASKFAAAVSNDGAPVVATSRVKVFFTDAASAQRAATATGGTVVKVSKASGRAIVEYPSVNAALDATTKLLSTAGIKAAEPDVVQWEETK
>NZ_AP021867.1|WP_153676246.1|4266879_4267551_-|SCO-family-protein
MFSPRFRLPLLAGLAIGLLAGCSSQSRMDFYSKDIACEELGQQWSMPDSHGTVRGPKDLQGQVTYLFFGFTSCPDVCPTTMVELSQVKHLMGKDADQLQVVFVSVDPARDTPEVARTYVEAFDPKAIALVGNEAQLAAMASDFKAFYEKEPGQVPETYTMSHIAGGYVFDRQGRLRLFAPYGMPVDKLFSDVQRLLLEPGHPAAGNDALASCHLKRSDTLAAR
>NZ_AP021867.1|WP_006399830.1|4267694_4268027_-|cytochrome-o-ubiquinol-oxidase-subunit-IV
MAHVETSRAGNAHGSTKSYLIGFVLCALLTVVPFALVMNPVLSRPLTLFLLVGFAVAQILVQLVYFLHMDRKSEGGWNLASFVFTLVILFIVVALSVWIIWSMHYHMMIN
>NZ_AP021867.1|WP_012512371.1|4268028_4268664_-|cytochrome-o-ubiquinol-oxidase-subunit-III
MNLLTRPELASDTQAHEDHHEHDHGHEQGGMKVFGMWVYLMSDLVLFGSLFASYAVLSTAYAGGPTGKDLFSLPFVMAETFLLLVSSITYGQAVLAMHRHDTSAVLRWLGVTFVLGASFIGMEIYEFSHLIHEGAGPSTSAYLSAFFALVATHGLHVASGLIWMAVVMHQVYSRGLTPTNITRVSCLSLFWHFLDLVWICVFTFVYLIGAF
>NZ_AP021867.1|WP_100469848.1|4268660_4270637_-|cytochrome-o-ubiquinol-oxidase-subunit-I
MLGKLTWEAVPLHEPIVVITLAAMVLGGLALLGAVTYFRLWGPLWRDWFTTVDHKKIGIMYVVVALVMLVRGFADALMMRAQLAAAGPGSDGFLPPEHYDQIFTAHGVIMIFFVATPFVVGLMNIIVPLQIGARDMAFPFLNAFSFWIFVVGAALMMISLGVGEFAMTGWVAYPPLSGIEFSPGVGVDYYIWALQASGIGTLLTGVNLFITILRMRAPGMTLMKMPVFTWTVLVTSVIIIAAFPILTVALGALTLDRYLDFNFYTNTLGGNPMMYVNLVWAWGHPEVYILVLPAFGIFSEVTATFARKKLFGYKSMVGATLAIGILSFIVWLHHFFTMGSGASVNAFFGIMTMIIAIPTGVKIFTWLFTMYGGRVEFSVPMLWTIAFLVTFTIGGMTGVLLAIPGADFLLHNSLFLVAHFHNTIIGGALFGYLAGFAYWFPKVFGFTLNERLGKWSFACWVIGFYLAFMPLYMLGFMGMTRRMNQYDNPAWTPYLIAAFIGALFVFAGIILMLVQIYVSVRDRKRNLDLTGDPWNARTLEWATPSPPPFYNFAVVPKADELDAFHEAKKRGLPPPPKKYAPIHMPKNTGVPLILNIWILVLCFALVWHIWWMAAASFIAMIVTLIVRSYDEDVDYYVSSEEVARTEAANLAKLKEVRA

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Crispr_ID: NZ_AP021867_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP021867_16

4502044-4502146

Orphan

Consensus_repeat	Method
GTTGCCAACCTTGGTTGGCGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP021867_16

>merge|NZ_AP021867|16|4502044-4502146|CRISPRCasFinder
GTTGCCAACCTTGGTTGGCGCCGCTCTTCGCGGGAACCACGCGTGGCGTGGATCTACTGCCGGTCAGCCTGCCGTGGGTCGCTGCCAACCTTGGTTGGCGCCG

>NZ_AP021867|16|16|4502044-4502146|CRISPRCasFinder
GTTGCCAACCTTGGTTGGCGCCG	CTCTTCGCGGGAACCACGCGTGGCGTGGATCTACTGCCGGTCAGCCTGCCGTGGGTC
GCTGCCAACCTTGGTTGGCGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP021867.1\|WP_012512522.1\|4496637_4497537_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|211400
NZ_AP021867.1\|WP_100435671.1\|4515873_4516740_-\|D-hexose-6-phosphate-mutarotase	unknown	unknown	gnl\|CDD\|185697
NZ_AP021867.1\|WP_153676200.1\|4491479_4493315_+\|Flp-pilus-assembly-complex-ATPase-component-TadA	unknown	unknown	gnl\|CDD\|225363
NZ_AP021867.1\|WP_004141396.1\|4521810_4522203_-\|YchJ-family-protein	unknown	unknown	gnl\|CDD\|235261
NZ_AP021867.1\|WP_100435670.1\|4516780_4518049_-\|lytic-murein-transglycosylase	unknown	unknown	gnl\|CDD\|372592
NZ_AP021867.1\|WP_100435500.1\|4497702_4498665_+\|ferrochelatase	unknown	unknown	gnl\|CDD\|234585
NZ_AP021867.1\|WP_153676202.1\|4495830_4496319_-\|twin-arginine-translocase-subunit-TatB	unknown	unknown	gnl\|CDD\|135173
NZ_AP021867.1\|WP_153676203.1\|4499806_4501912_+\|chemotaxis-protein	unknown	unknown	gnl\|CDD\|185001
NZ_AP021867.1\|WP_032128455.1\|4495084_4495834_-\|twin-arginine-translocase-subunit-TatC	unknown	unknown	gnl\|CDD\|182840
NZ_AP021867.1\|WP_004141410.1\|4515049_4515823_-\|DUF2628-domain-containing-protein	unknown	unknown	gnl\|CDD\|379517
NZ_AP021867.1\|WP_100435668.1\|4520526_4521807_+\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NZ_AP021867.1\|WP_012512533.1\|4522306_4523086_+\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|182593
NZ_AP021867.1\|WP_153676201.1\|4493286_4494033_+\|glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|181635
NZ_AP021867.1\|WP_012512521.1\|4496334_4496562_-\|Sec-independent-protein-translocase-subunit-TatA	unknown	unknown	gnl\|CDD\|179864
NZ_AP021867.1\|WP_100435667.1\|4523182_4526563_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|227250
NZ_AP021867.1\|WP_012512531.1\|4519104_4520376_-\|ergothioneine-biosynthesis-protein-EgtB	unknown	unknown	gnl\|CDD\|274581
NZ_AP021867.1\|WP_065723752.1\|4494084_4494996_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021867.1\|WP_100467688.1\|4513855_4515043_+\|benzoate/H(+)-symporter-BenE-family-transporter	unknown	unknown	gnl\|CDD\|281578
NZ_AP021867.1\|WP_100435669.1\|4518133_4519108_-\|L-histidine-N(alpha)-methyltransferase	unknown	unknown	gnl\|CDD\|274579
NZ_AP021867.1\|WP_100435501.1\|4498661_4499516_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669

Protein	Function_ID	Function_description	E-value
NZ_AP021867.1\|WP_012512522.1\|4496637_4497537_-\|hypothetical-protein	gnl\|CDD\|211400	cd11524, SYLF, The SYLF domain (also called DUF500), a novel lipid-binding module. The SYLF domain is named after SH3YL1, Ysc84p/Lsb4p, Lsb3p, and plant FYVE, which are proteins that contain it. It is also called DUF500 and is highly conserved from bacteria to mammals. Some members, such as SH3YL1, Ysc84p, and Lsb3p, which represent the best characterized members of the family, also contain an SH3 domain, while family members from plants and stramenopiles also contain a FYVE zinc finger domain. Other members only contain a stand-alone SYLF domain. The SYLF domain of SH3YL1 binds phosphoinositides with high affinity, while the N-terminal SYLF domains of both Ysc84p and Lsb3p have been shown to bind and bundle actin filaments, as well as bind liposomes with high affinity.	9.57065e-79
NZ_AP021867.1\|WP_100435671.1\|4515873_4516740_-\|D-hexose-6-phosphate-mutarotase	gnl\|CDD\|185697	cd09020, D-hex-6-P-epi_like, D-hexose-6-phosphate epimerase-like. D-Hexose-6-phosphate epimerase Ymr099c from Saccharomyces cerevisiae belongs to the large superfamily of aldose-1-epimerases. Its active site is very similar to the catalytic site of galactose mutarotase, the best studied member of the superfamily. It also contains the conserved glutamate and histidine residues that have been shown in galactose mutarotase to be critical for catalysis, the glutamate serving as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen. In addition Ymr099c contains 2 conserved arginine residues which are involved in phosphate binding, and exhibits hexose-6-phosphate mutarotase activity on glucose-6-P, galactose-6-P and mannose-6-P.	2.95952e-101
NZ_AP021867.1\|WP_153676200.1\|4491479_4493315_+\|Flp-pilus-assembly-complex-ATPase-component-TadA	gnl\|CDD\|225363	COG2804, PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion].	0
NZ_AP021867.1\|WP_004141396.1\|4521810_4522203_-\|YchJ-family-protein	gnl\|CDD\|235261	PRK04233, PRK04233, hypothetical protein; Provisional.	6.16531e-80
NZ_AP021867.1\|WP_100435670.1\|4516780_4518049_-\|lytic-murein-transglycosylase	gnl\|CDD\|372592	pfam13406, SLT_2, Transglycosylase SLT domain. This family is related to the SLT domain pfam01464.	8.55566e-142
NZ_AP021867.1\|WP_100435500.1\|4497702_4498665_+\|ferrochelatase	gnl\|CDD\|234585	PRK00035, hemH, ferrochelatase; Reviewed.	2.89875e-141
NZ_AP021867.1\|WP_153676202.1\|4495830_4496319_-\|twin-arginine-translocase-subunit-TatB	gnl\|CDD\|135173	PRK04654, PRK04654, sec-independent translocase; Provisional.	1.74287e-32
NZ_AP021867.1\|WP_153676203.1\|4499806_4501912_+\|chemotaxis-protein	gnl\|CDD\|185001	PRK15041, PRK15041, methyl-accepting chemotaxis protein.	8.86762e-85
NZ_AP021867.1\|WP_032128455.1\|4495084_4495834_-\|twin-arginine-translocase-subunit-TatC	gnl\|CDD\|182840	PRK10921, PRK10921, Sec-independent protein translocase subunit TatC.	4.83224e-83
NZ_AP021867.1\|WP_004141410.1\|4515049_4515823_-\|DUF2628-domain-containing-protein	gnl\|CDD\|379517	pfam14237, DUF4339, Domain of unknown function (DUF4339). This domain is found in bacteria, archaea and eukaryotes, and is approximately 50 amino acids in length. There are two completely conserved residues (G and W) that may be functionally important.	6.52771e-13
NZ_AP021867.1\|WP_100435668.1\|4520526_4521807_+\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	4.30253e-46
NZ_AP021867.1\|WP_012512533.1\|4522306_4523086_+\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	6.22572e-35
NZ_AP021867.1\|WP_153676201.1\|4493286_4494033_+\|glutamine-amidotransferase	gnl\|CDD\|181635	PRK09065, PRK09065, glutamine amidotransferase; Provisional.	6.70653e-129
NZ_AP021867.1\|WP_012512521.1\|4496334_4496562_-\|Sec-independent-protein-translocase-subunit-TatA	gnl\|CDD\|179864	PRK04561, tatA, twin arginine translocase protein A; Provisional.	2.80012e-45
NZ_AP021867.1\|WP_100435667.1\|4523182_4526563_-\|ATP-binding-protein	gnl\|CDD\|227250	COG4913, COG4913, Uncharacterized protein conserved in bacteria [Function unknown].	0
NZ_AP021867.1\|WP_012512531.1\|4519104_4520376_-\|ergothioneine-biosynthesis-protein-EgtB	gnl\|CDD\|274581	TIGR03440, egtB_TIGR03440, ergothioneine biosynthesis protein EgtB. Members of this family include EgtB, and enzyme of the ergothioneine biosynthesis, as found in numerous Actinobacteria. Characterized homologs to this family include a formylglycine-generating enzyme that serves as a maturase for an aerobic sulfatase (cf. the radical SAM enzymes that serve as anaerobic sulfatase maturases). [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	0
NZ_AP021867.1\|WP_100467688.1\|4513855_4515043_+\|benzoate/H(+)-symporter-BenE-family-transporter	gnl\|CDD\|281578	pfam03594, BenE, Benzoate membrane transport protein.	2.24016e-132
NZ_AP021867.1\|WP_100435669.1\|4518133_4519108_-\|L-histidine-N(alpha)-methyltransferase	gnl\|CDD\|274579	TIGR03438, conserved_hypothetical_protein, dimethylhistidine N-methyltransferase. This model represents a distinct set of uncharacterized proteins found in the bacteria. Analysis by PSI-BLAST shows remote sequence homology to methyltransferases [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	4.81116e-146
NZ_AP021867.1\|WP_100435501.1\|4498661_4499516_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.16549e-19

>NZ_AP021867.1|WP_153676203.1|4499806_4501912_+|chemotaxis-protein
MSIASSRPPDTARLPHLQQLARSADRRLLLGSAALAVAGLLLAVRGPQVLSASLAAVAVLPAVWLAGPQAGQAIARNGLALLLSLQLTLLCAITGLSPALPIALLLGALLGHRDRLPVWLAGGVGTLALLAPMLDGAAVLPTVLPAALLAGLTLFLGQVALRLRQQTEALGHGPRRLAALARDIATGADLGAHTDTSAYAPGSLAHALADTARHVQAQRGREAEANAENAQIRQALDASRTAMMIADNDHVIRYVNRSVVALLRNQQATLRQAFPDFDAERLVGSSIHRFHANPDRIRAILNGLQVTHNGKVQIGPVHFAQVVTPVFDAQGARLGFAVEWHDRTHELALENAVAGIVAAAAAGDLDQRLQASEGASFLDGLTGGINQLLDTLGGTIDEVRQMLSALANGDLDRRMHGEYHGAFAAIQRDANATAGQLARMVGHIQQCAASISTAASEIAAGNGALSERSERQAAHLQETAASMEELTATVRQNAAHAREASTLAAATQSAASDGNAAMQQVVDTMQAIEGASKRIGDITGVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVASEVRVLAQRSAAAAQEIKKLIDEAGRQVGDGAQQVADAGQRMQGIVGGVENVSHLMREISAASQEQSIGIEQINQTVVQMDQATQQNAALVEEATAAARELQSQAGTLTEAVSVFRQQAPQGIALVA
>NZ_AP021867.1|WP_100435501.1|4498661_4499516_+|alpha/beta-hydrolase
MSLQPFELEVGGTRVAGLRNHGDGPRVLALHGWLDNAASFMPLAPHLSSLQLVAIDLPGHGHSAHLPAGASYTTAAAICHVLDVADALGWDRFTLLGHSMGAGIASLTASVSDRIERLVAIEALGGLRGPEEETANRLREHVNATRGLARKQLRVFPDLAAPIRARMMTNQLSEGCARLLVERGVEPVEGGYRWCSDPRLMLPTAIRLSEGQIDNLLQAIACPTQVIYATPAQSYYPEPMRSDRLRHLRDGRLAVFPGNHHLHMEDPARIAEVILRFFNNDNAS
>NZ_AP021867.1|WP_100435500.1|4497702_4498665_+|ferrochelatase
MLDAPDTAVLAVNLGTPETPTAPAVRRYLAEFLSDPRVVSIPALLWQPLLRGLILPLRSSRSAAKYAQVWLPDGSPLMVYTRQLAQAMQALLPSLTVRHAMRYGEPALGSELDRLAAEGARRIVVLPLYPQYSTTTTASVEDRVDAWQRRNPGVTVSLVRDYSVDPGWVEAVAGSIRRYWEQHGRGQTLMFSFHGIPQRLADGGDPYPQRCEASARAIANALGLASDEWQLGYQSRFGRERWLQPYAEPSLWALAESGVKQIDVVCPGFATDCLETLEEVAMGFTETLAERGATMRYIPCLNAEPDHARALARLAVASLA
>NZ_AP021867.1|WP_012512522.1|4496637_4497537_-|hypothetical-protein
MRRPIQALLIAATLLSSQAMAGPQEDQRARNAVRVLAEIQGIPEQGIPDKLLDEGRAVIVIPDTIKAGLVIGGRRGHGLMSVRMPNGAWSNPVFIKLTGGSIGFQAGVQSSDVVLVFRNDRSLDNLVNGKFTLGADAGVAAGPVGRNAAAATDGQLKAEIWSWSRARGLFAGVALDGAVLQIDDAANLDAYGSNTTPRMIFEGRAAGSPSMDVVAFRDRLEEATYAARNNRNGNGNGGNAPRPAAAPAAAPAPVQAAPAAPAEATTAPLQNVPQTPPPQQQGFQPVTDGEIRTETLGGN
>NZ_AP021867.1|WP_012512521.1|4496334_4496562_-|Sec-independent-protein-translocase-subunit-TatA
MGSFSIWHWLVVLAIVLLVFGTKRLTSGAKDLGSAVKEFKKGMRDEDKPNAQLGDESRSQDASRTAQDEHDRTPR
>NZ_AP021867.1|WP_153676202.1|4495830_4496319_-|twin-arginine-translocase-subunit-TatB
MFDIGFSELLVIAVVALVVLGPERLPKAARFAGLWVRRARNQWDSVKQELERELQAEDIKRQMQDVRQGMQDTENQLRASGEAIRREAQQQGDDLVQEVRTPAQADLPPHLSQPSETDAPAQDSGPVSTTAATEGVVSSGAVPATSAEAGPTPPTQSTERHP
>NZ_AP021867.1|WP_032128455.1|4495084_4495834_-|twin-arginine-translocase-subunit-TatC
MSEQDFGESSLVEHLVELRGRLVRALLGLGVVLLALLPFTQKLYNALAEPLVSQLPNGQTMIATNPAGAFFAPLKLTFFVALFVAVPWLLYQLWAFVAPGLYAREKRLAVPLLVSSVLLFYAGCAFAYFLVLPAVFHFLTTFSPDVIAITPDANAYLDFVLAIFFAFGGSFELPVAMVILVLLGWVTPQQFKEGRGYAIVGIFVVAAVLTPPDVVSQLMLAIPMCLLYELGIHAARWLVPSSVVKKPAA
>NZ_AP021867.1|WP_065723752.1|4494084_4494996_+|hypothetical-protein
MKEIRKLPASAGAQWLLDTFSLYRRAPLQLARIGLTWLLVSWVVTLLSTLIPGAAGMAVQLMTLAISPIMFGGMLYAVGEIDEGRPGLASHLLQPIRDHRVSHLLVPLAIQVLAVLLLGALLFMMIGREGFTAFSEVMTKMEEISRSGQQIKPDDAAALVANLPAKRIALWMLLVFLSAVALSLAMFTQPALVVFDKQSGMHALRLSLQGCIENIGAMIVFAVLGLIAAFCMYILFVIVIQIAMLIGGPLAAAFIAQLVLTTVLMPLYVGAVYAAWKQMFVHRGSRAAPPIPTTPTSSDVFHA
>NZ_AP021867.1|WP_153676201.1|4493286_4494033_+|glutamine-amidotransferase
MNPAPFLILETGRPVPSLRRYGRFPHWIRVAAGLEEHETVVVDVEHGDALPDAGAYAGVLVTGSAAFVTDHAEWSERSAAWLRQTAHDDVPVFGICYGHQLLAHALGGEVAYNPAGRESGTIELALDPQAAQDPLFQGLPQHFAAHATHLQTVLRVPEGAAVLARSPLDGCHAFRWGRQAWGVQFHPEFATHHMRGYVRARADCIGRHGGCARSIERAVSAAPLARQLLRRFVRQARLSSAQPATKQG
>NZ_AP021867.1|WP_153676200.1|4491479_4493315_+|Flp-pilus-assembly-complex-ATPase-component-TadA
MEHRLPAGTPGEPGAAPLPPGRLQFEQVAAALLADGVVAAHERERMRFSAQGARNASEVHPLVLLSNLKLAASEGGDLTLERLTEWLARHTGSRYLRIDPTRVDVASVTAVASHAYARRHRFLPLAVDAERVLVATSEPLAQEWLRDLQHLTRRRIELAVVNPLDLHRYTMEFYGVTRSVRGARGDVRGETSTTLPSFEQLVELGRAGDVNADDQHIVHIVDWLLQYAYEQRASDIHLEPRREMGRMRFRIDGVLHKVFEVPPAVMTAVVSRIKVLGRMDLAERRRPQDGRIKTRSPGGREVEMRLSTMPTAFGEKCVMRIFDPDAAFKSIDQLGFSPQEAAGWTALVERPHGIVLVTGPTGSGKTTTLYSTLKRLATPDVNVCTVEDPIEMIAAEFNQMQVQTNIDLDFASGVRTLLRQDPDIIMIGEIRDLETAQMAVQASLTGHLVLSTLHTNDAASAITRLLDIGVPHYLLASTLNGILAQRLVRTLCPHCKQPHTLERTDWAVLADSQAAYPDAATPCRPVGCLECRRTGFLGRIGLYELLPLGSRLRALIRADMDLAGFHRAARAEGLRTLRQAGLEKVAQGLTTIEEVLSVLPPPDESSTLPDP
>NZ_AP021867.1|WP_100467688.1|4513855_4515043_+|benzoate/H(+)-symporter-BenE-family-transporter
MNMQVRQAWWRDLSVPALVAGFITVLVGFASSAVIVFQAAQAVGANQAQIASWMWALGLGMGVTCIGLSLRYRVPVVTAWSTPGAAMLVVGAGGASLAEATGAFLLAAVLGMLAGFSGIFARLMQRVPMALAAGMLAGVLLRFGLDVFVAMNTQLVLALAMFATWLGGRRLFPRYAVIATLLVGIAVAASRGLLHAQQVQLQLAVPQWVTPSLSWTAVAGIALPLFVVTMASQNIPGVAVMRASGYEAPVSPLIGWIGVVNTLLAPFGAYALNLAAITAAICMGRDAHEDPARRYTAAMAAGAFYIVVGLFGATVAALFAAFPKELVACVAGIALFGTIGNSLASALAVERDREAALVTFLVTASGVSLAGIGSAFWGLVAGALCLLVLRPRQAG
>NZ_AP021867.1|WP_004141410.1|4515049_4515823_-|DUF2628-domain-containing-protein
MQEAQWWYANGRQSSGPVDLAGLRKLQQDGTVTARTLLWCEGMPSWRPLAELDQVSTPIEVVPAPDIDAAPVVEGIAPSVGDPSDPYRAPATAPDTAAAAGLEGELALYASVVGGNFPIYRQRWRLDQGIATGTGTWHWPAFLLGLVWMMYRKMYRLAAMWAGLLLLISVVETLLDVPDGLSLVITFALSITTGIFGNSWYLAHCQRLIAQARTVTGGDDTRLRSELTARGGTSVVATLIAIVIAVVLSTVGAALAG
>NZ_AP021867.1|WP_100435671.1|4515873_4516740_-|D-hexose-6-phosphate-mutarotase
MQSNPDISSGLYHGLEAWQVRTANATAVISVFGGQLLSFIPEGQHDLLWLSPTRAELPTPIRGGVPVCWPWFGRQGQDTDVPAHGLVRTVRWELQQVRQNDTGELELQLAPPLPADLGLRLQMQLRIGHQLHQQLTSENIGSAPVTFTQALHSYFRVGDAGRVEVDGLDGLQYLDKYEDYAQARLQQGPWSLRDPRDPGRSDRIYTGAGGHYALRDPVLQRRIEIRSEGSQTLVAWNPGADAAAKMADVGDGWHDYVCLEVANAGPEQITLAPGERHRLAQTLASAPL
>NZ_AP021867.1|WP_100435670.1|4516780_4518049_-|lytic-murein-transglycosylase
MPILITLGLAAALASTPAQPTAPDPGLDPAFSRCLAGLQAAVASQGISADRFNEITADLTPDPSVLGLLDAQPEFTTPIWDYLAALVDRQRVDDGRAMLQQHRDLLDRVSAQYGVDPTTIVAVWGVESDYGRVFGKRPLLQSLATLSCAGRRQAFFRGELLALLKLIDRGDLQAQGLTGSWAGAFGHTQFMPSTYARIAVDGDGDGRRDLVGSIPDALASTANYLKRAGWRSGEPWGMEVRIPAGFNASQAGRTQRRALADWRAQGVTALDGSALAPANLPADARAALLLPAGNKGPALLVFRNYDAIYSYNAAESYALAIATLADQLRGGNGLATAWPTDDPGLGRDERRQLQTLLLARGHDIGSADGMIGTATRRAIQSEQQRLGWTNADGRAGQRILRTLQEEAAAAAPGVQKALPQAR
>NZ_AP021867.1|WP_100435669.1|4518133_4519108_-|L-histidine-N(alpha)-methyltransferase
MSTVHDALQALTDLTPGRQQILSDVVAGLSRTPRQLPSKYFYDARGSRLFEQITQTPEYYPTRTELALLKRVLPDVARTVGPRLHVVELGSGSGRKTALLLAALHDPVAYTPIEISRAALLSSIDHLAPALPEVEMLPVCADFTRPVAVPMPEREPARRLLFFPGSTLGNFEGEDAVALLRAMRQTMGRDGLALVGIDLHKDPALIEAAYNDAQGVTAAFTLNLLARLNREIGSDFDLDGFHHRACYSTARLRIETDLVSRWAQDVHLDGRAFHFAADEPIRVEYSHKYTDDSFEALLQQAGLQATQRWNADSPAYGLRLLRAI
>NZ_AP021867.1|WP_012512531.1|4519104_4520376_-|ergothioneine-biosynthesis-protein-EgtB
MDSVPAAVAAPQHDLARQFAHVRTRSLQLAAPLSAEDAMLQSMADASPSKWHLAHTTWFFERFVLAGFGTAPAHDPAWDYLFNSYYKSIGPAHARPQRGLLSRPSLQQVRDYRKQVDAQVQSRLAAGDLDEQALQHLQLGLQHEQQHQELLLTDIKHAFWCNPLQPPYREDLQPVAGNASAQGWIESPERIVTVGAAAWPQQAAFAYDNESPAHRVVLPAHALAERPVSNAEYHAFIEAGGYREPRWWLSEGWALREAEGWQHPLYWDDDLQREYTLGGWRALDPHAPVCHLSYYEADACARWAGARLPSEFEWEAAATSQPVSGHFAEDDHLHPLAGQGSGLRQLFGDVWEWTQSAYGAYPGFRPFAGNLGEYNGKFMCGQWVLRGGSCATPRGHVRASYRNFFMPPARWQFSGLRLARDLT
>NZ_AP021867.1|WP_100435668.1|4520526_4521807_+|GGDEF-domain-containing-protein
MPLHPLRQPAHYLFVLPAMLVAVVLCTALDTADVASPAQRILPWLLACLGAGLALLYHQIRSLCLLLVVAVMFALLHQDVGGYLRSGHVGALTPLRFHAISAWLPLLFTGLSLWPERGRRRQDLLLRGVVCSVALLIFLLLATQQPRGMHDLLSNRHWAWIPADWNALAQLPALLFLLATAALGWQAWRHPRPLHTAMLLALLCLWWMLPRMFLQPVLLPALSCAALLLVLGAMLQESFHMAFRDELTGLPGRRAFNETLQRARGTYSIAMVDVDHFKSFNDTHGHDTGDDVLRLVASRLARVGDGGRAFRYGGEEFAVVFLDRPATACVDAVEALRQSIEDTRMQLRDRSTRSRDDEAGRQQRGRGGSGQVVQVTVSIGLADSRVDQRPTAVVKAADQALYAAKDGGRNQVHAQAGQRVLAMRGG
>NZ_AP021867.1|WP_004141396.1|4521810_4522203_-|YchJ-family-protein
MSRKPADPCPCGLPADYAACCGRFHAGDAAPDAERLMRSRYSAYVRGLADYLRQTWHPDTRPAELTLDDAPGQRTHWLGLTVHEHTITGADSADVRFTARYRIGGGSAVKMTEHSRFQRIEGRWYYLDAV
>NZ_AP021867.1|WP_012512533.1|4522306_4523086_+|sulfite-exporter-TauE/SafE-family-protein
MLELVPPELWWLVVIAFIAGLVDAAVGGGGLVQLPGLFTVLPQQTPAMLFGTNKFSSMFGTGAAAWRYARNVRFPWKPVLFAAGTAFIFSFAGATAVSLLPKDAVRPLVLVLLIAMLAYTLWKKDFGALHRPQEIGRRELAIALAIGAAIGFYDGFFGPGTGSFLIFLFVRFFGLDFLRASAASKVVNLATNVAAISFFVPTGNILWLFALPMAAANIIGSVVGTRLALKGGTPFIRKLFVGLVVVLIARMAWDTLRGA
>NZ_AP021867.1|WP_100435667.1|4523182_4526563_-|ATP-binding-protein
MAISKHTPALFNEGLPDPRLQQFRMRRLQVHNWGTFNGLTEVPIAERGFLFVGRSGSGKSTLLDAMSALLTPPAIVDFNAAAREAERSGRDRNLVSYVRGAWADQQDSGTGEIATQYLRKGATWTALVLEYRAGDGRVVSLVRLLWISGNGTSAGDVRKHYMIAERPFDIAKDLGGFDLDLRKLKQKLSDLHHFDTFSGYAERFRDLLGIDNEMALRLLHKTQSAKNLGDLNVFLRDFMLDTPKTFDAAERLVSDFAELDGAHQAVVTARRQVETLLPARAYYNDLKEMHRQRGDDEALKLGVDSFRESRRQALIEARLREMDVRDRGLLGEEAQRRAALDNHTERLAELELQRRQQGGERIEELEREQGRAEAERDRRKAKRDQAQEAAQQLQAELPDDAHGFAELVERAQNELQDRQRASAALDDAISDRLGGKRDDERRFGEVRSELEAMQRTPSNIPAPMQKLRARLAEETGIAEAALPFVGELIQVRSEEQGWQGAIERVLGGFALSLLVDDKHYNDVAEWVNRTHLGMRFTYYRVRRNDDAFAREPSAKSLLHKLELREHVFESWLRRELGKRFDYECVDAKQLRNVDRGITREGQVKHPGDRFEKDDRSAVGDRRRWILGFNNHDKVGAFEREAQELAKRIASCETDIARLRGQRDRDNERRLACHELVSISWNEIDIAAPQQRLSDIEATLRDLREGNADLAKLAKQIDAVRADIEQARRTYEDVRVERGQLVKERDRLDRARQQSRALVLPSLAQEHEAGLAERLQEQGPLSLETLEAHMRQVSNTLNEQLSSSQQDLNRIENQLIGCFRRFIQQWPEESGDFTVSVASAEDFLARLERLERDGLPQHEERFFDLLQNQSKNNLLALQRHSAEARKSIGQRLDEVNASLEQVPFNRGTLLTIELSDRRLPEVGEFHLQLREVLSQQQTEQRELAESQFTVLRQLVNRLGSQEGEDKRWRELVLDVRMHVEFIGVELDAETRQQVEIYRSGAGKSGGQRQKLATTCLAAALRYQLGGADSQLPSYAAVVLDEAFDKADNEFTALAMNIFDNFGFQMVVATPLKSVMTLEPFIGGACFVEISGRHDSGVLLIEYDEEGKRLKLPERSRQQANEPEEAEA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_AP021867_14	14.1\|4198970\|49\|NZ_AP021867\|CRISPRCasFinder	4198970-4199018	49	NZ_AP021867.1	4199119-4199167	1	0.98

1. spacer 14.1|4198970|49|NZ_AP021867|CRISPRCasFinder matches to position: 4199119-4199167, mismatch: 1, identity: 0.98

tacggagccaaccgcatccacgcatggcgtggatctaccgaccgcaatg	CRISPR spacer
tacggagccaaccgcatacacgcatggcgtggatctaccgaccgcaatg	Protospacer
***************** *******************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP021867_5	5.1\|1398735\|25\|NZ_AP021867\|CRISPRCasFinder	1398735-1398759	25	NZ_CP039697	Novosphingobium sp. ABRDHK2 plasmid pABRDHK22, complete sequence	510473-510497	4	0.84
NZ_AP021867_5	5.1\|1398735\|25\|NZ_AP021867\|CRISPRCasFinder	1398735-1398759	25	NC_008271	Rhodococcus jostii RHA1 plasmid pRHL3, complete sequence	9730-9754	4	0.84
NZ_AP021867_5	5.1\|1398735\|25\|NZ_AP021867\|CRISPRCasFinder	1398735-1398759	25	NZ_CP049244	Rhizobium pseudoryzae strain DSM 19479 plasmid unnamed3, complete sequence	1001699-1001723	4	0.84
NZ_AP021867_5	5.1\|1398735\|25\|NZ_AP021867\|CRISPRCasFinder	1398735-1398759	25	NZ_CP031754	Rhodobacter sphaeroides strain EBL0706 plasmid p.C, complete sequence	14127-14151	4	0.84
NZ_AP021867_12	12.1\|3850406\|28\|NZ_AP021867\|CRISPRCasFinder	3850406-3850433	28	NZ_CP048424	Rhizobium daejeonense strain KACC 13094 plasmid unnamed1, complete sequence	238673-238700	5	0.821
NZ_AP021867_1	1.1\|760766\|29\|NZ_AP021867\|CRISPRCasFinder	760766-760794	29	NZ_CP014309	Burkholderia sp. PAMC 26561 plasmid unnamed2, complete sequence	785164-785192	6	0.793
NZ_AP021867_1	1.1\|760766\|29\|NZ_AP021867\|CRISPRCasFinder	760766-760794	29	NZ_CP014310	Burkholderia sp. PAMC 26561 plasmid unnamed3, complete sequence	218754-218782	6	0.793
NZ_AP021867_1	1.1\|760766\|29\|NZ_AP021867\|CRISPRCasFinder	760766-760794	29	NZ_CP014310	Burkholderia sp. PAMC 26561 plasmid unnamed3, complete sequence	231612-231640	6	0.793
NZ_AP021867_1	1.1\|760766\|29\|NZ_AP021867\|CRISPRCasFinder	760766-760794	29	NZ_CP014308	Burkholderia sp. PAMC 26561 plasmid unnamed1, complete sequence	49948-49976	6	0.793
NZ_AP021867_12	12.1\|3850406\|28\|NZ_AP021867\|CRISPRCasFinder	3850406-3850433	28	NZ_CP022299	Acinetobacter johnsonii strain IC001 plasmid pIC001A, complete sequence	13387-13414	7	0.75
NZ_AP021867_2	2.1\|773602\|31\|NZ_AP021867\|CRISPRCasFinder	773602-773632	31	KY514263	Pectobacterium phage vB_PatM_CB7, complete genome	25485-25515	9	0.71

1. spacer 5.1|1398735|25|NZ_AP021867|CRISPRCasFinder matches to NZ_CP039697 (Novosphingobium sp. ABRDHK2 plasmid pABRDHK22, complete sequence) position: , mismatch: 4, identity: 0.84

atggcatcgtccagcgatccgaacc	CRISPR spacer
tcgtcatcgtccatcgatccgaacc	Protospacer
 .* ********* ***********

2. spacer 5.1|1398735|25|NZ_AP021867|CRISPRCasFinder matches to NC_008271 (Rhodococcus jostii RHA1 plasmid pRHL3, complete sequence) position: , mismatch: 4, identity: 0.84

atggcatcgtccagcgatccgaacc	CRISPR spacer
gtggcatcgtccaggaatccgaacg	Protospacer
.************* .********

3. spacer 5.1|1398735|25|NZ_AP021867|CRISPRCasFinder matches to NZ_CP049244 (Rhizobium pseudoryzae strain DSM 19479 plasmid unnamed3, complete sequence) position: , mismatch: 4, identity: 0.84

atggcatcgtccagcgatccgaacc	CRISPR spacer
atgccgtcgtccagcgatccgaagt	Protospacer
*** *.***************** .

4. spacer 5.1|1398735|25|NZ_AP021867|CRISPRCasFinder matches to NZ_CP031754 (Rhodobacter sphaeroides strain EBL0706 plasmid p.C, complete sequence) position: , mismatch: 4, identity: 0.84

atggcatcgtccagcgatccgaacc	CRISPR spacer
gggccatcgtcaagcgatccgaacc	Protospacer
. * ******* *************

5. spacer 12.1|3850406|28|NZ_AP021867|CRISPRCasFinder matches to NZ_CP048424 (Rhizobium daejeonense strain KACC 13094 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.821

aggttcatggcgtcggcggaataggtgc	CRISPR spacer
gggttcatggcatctgcggaatagccgc	Protospacer
.**********.** ********* .**

6. spacer 1.1|760766|29|NZ_AP021867|CRISPRCasFinder matches to NZ_CP014309 (Burkholderia sp. PAMC 26561 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.793

atcgcgcgcagcgcagaatgtgtggtccc	CRISPR spacer
atcgcgcgcggcgcataatgtgtcgaacg	Protospacer
*********.***** ******* *  *

7. spacer 1.1|760766|29|NZ_AP021867|CRISPRCasFinder matches to NZ_CP014310 (Burkholderia sp. PAMC 26561 plasmid unnamed3, complete sequence) position: , mismatch: 6, identity: 0.793

atcgcgcgcagcgcagaatgtgtggtccc	CRISPR spacer
atcgcgcgcggcgcataatgtgtcgaacg	Protospacer
*********.***** ******* *  *

8. spacer 1.1|760766|29|NZ_AP021867|CRISPRCasFinder matches to NZ_CP014310 (Burkholderia sp. PAMC 26561 plasmid unnamed3, complete sequence) position: , mismatch: 6, identity: 0.793

atcgcgcgcagcgcagaatgtgtggtccc	CRISPR spacer
atcgcgcgcggcgcataatgtgtcgaacg	Protospacer
*********.***** ******* *  *

9. spacer 1.1|760766|29|NZ_AP021867|CRISPRCasFinder matches to NZ_CP014308 (Burkholderia sp. PAMC 26561 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.793

atcgcgcgcagcgcagaatgtgtggtccc	CRISPR spacer
atcgcgcgcggcgcataatgtgtcgaacg	Protospacer
*********.***** ******* *  *

10. spacer 12.1|3850406|28|NZ_AP021867|CRISPRCasFinder matches to NZ_CP022299 (Acinetobacter johnsonii strain IC001 plasmid pIC001A, complete sequence) position: , mismatch: 7, identity: 0.75

aggttcatggcgtcggcggaataggtgc	CRISPR spacer
gcgatcatggcgtcgccggaatagggag	Protospacer
. * *********** ********* .

11. spacer 2.1|773602|31|NZ_AP021867|CRISPRCasFinder matches to KY514263 (Pectobacterium phage vB_PatM_CB7, complete genome) position: , mismatch: 9, identity: 0.71

caggatcgccgcctctgtagagtcgagccgt	CRISPR spacer
gtatagcgccccctctgtagagtcgatccaa	Protospacer
  . * **** *************** **.

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage