CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP045929	Saccharopolyspora sp. E2A chromosome, complete genome	10 crisprs	csa3,cas3,c2c9_V-U4,DinG,DEDDh,cas4,WYL,casR	2	2	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP045929_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045929_1

340050-340157

Orphan

Consensus_repeat	Method
CGAGCAGACCGGAGTCATCCCTGCGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP045929_1

>merge|NZ_CP045929|1|340050-340157|CRISPRCasFinder
CGAGCAGACCGGAGTCATCCCTGCGGTCACGGACGGGACCACTGCGTCGTCGAGTGAACAGCGCCCGGCGGAGTCGGCGGCCGAGCGGACCGGAGTCATCCCTGCGGT

>NZ_CP045929|1|1|340050-340157|CRISPRCasFinder
CGAGCAGACCGGAGTCATCCCTGCGGT	CACGGACGGGACCACTGCGTCGTCGAGTGAACAGCGCCCGGCGGAGTCGGCGGC
CGAGCGGACCGGAGTCATCCCTGCGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045929.1\|WP_154075028.1\|344384_344942_+\|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223707
NZ_CP045929.1\|WP_154075026.1\|337736_338225_-\|inorganic-pyrophosphatase	unknown	unknown	gnl\|CDD\|376376
NZ_CP045929.1\|WP_154078537.1\|347697_348306_+\|GTP-cyclohydrolase-I-FolE	unknown	unknown	gnl\|CDD\|236472
NZ_CP045929.1\|WP_154075025.1\|335816_336659_+\|DUF4231-domain-containing-protein	unknown	unknown	gnl\|CDD\|379418
NZ_CP045929.1\|WP_154075021.1\|326541_327126_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045929.1\|WP_154075033.1\|350120_350693_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045929.1\|WP_154075022.1\|327314_330224_+\|type-I-DNA-topoisomerase	unknown	unknown	gnl\|CDD\|236048
NZ_CP045929.1\|WP_154075018.1\|321247_322867_+\|tannase/feruloyl-esterase-family-alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|284851
NZ_CP045929.1\|WP_154075019.1\|323222_325586_+\|sodium-translocating-pyrophosphatase	unknown	unknown	gnl\|CDD\|234827
NZ_CP045929.1\|WP_154075027.1\|343336_344353_+\|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl\|CDD\|238950
NZ_CP045929.1\|WP_154078535.1\|340293_341889_+\|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	unknown	unknown	gnl\|CDD\|200042
NZ_CP045929.1\|WP_154075020.1\|325720_326398_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371145
NZ_CP045929.1\|WP_154075024.1\|332481_335022_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|236645
NZ_CP045929.1\|WP_154075032.1\|349499_349994_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|223872
NZ_CP045929.1\|WP_154075031.1\|349143_349503_+\|dihydroneopterin-aldolase	unknown	unknown	gnl\|CDD\|224456
NZ_CP045929.1\|WP_154078534.1\|330886_332113_+\|DNA-polymerase-III-subunit-delta'	unknown	unknown	gnl\|CDD\|236134
NZ_CP045929.1\|WP_154075023.1\|330397_330748_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045929.1\|WP_154075030.1\|348305_349151_+\|dihydropteroate-synthase	unknown	unknown	gnl\|CDD\|238380
NZ_CP045929.1\|WP_154075029.1\|345177_347595_+\|ATP-dependent-zinc-metalloprotease-FtsH	unknown	unknown	gnl\|CDD\|273520
NZ_CP045929.1\|WP_154078536.1\|342087_343197_+\|coenzyme-F420-biosynthesis-associated-protein	unknown	unknown	gnl\|CDD\|274833

Protein	Function_ID	Function_description	E-value
NZ_CP045929.1\|WP_154075028.1\|344384_344942_+\|hypoxanthine-phosphoribosyltransferase	gnl\|CDD\|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	1.85507e-89
NZ_CP045929.1\|WP_154075026.1\|337736_338225_-\|inorganic-pyrophosphatase	gnl\|CDD\|376376	pfam00719, Pyrophosphatase, Inorganic pyrophosphatase.	3.62017e-82
NZ_CP045929.1\|WP_154078537.1\|347697_348306_+\|GTP-cyclohydrolase-I-FolE	gnl\|CDD\|236472	PRK09347, folE, GTP cyclohydrolase I; Provisional.	3.35965e-116
NZ_CP045929.1\|WP_154075025.1\|335816_336659_+\|DUF4231-domain-containing-protein	gnl\|CDD\|379418	pfam14015, DUF4231, Protein of unknown function (DUF4231). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 148 and 288 amino acids in length.	1.011e-05
NZ_CP045929.1\|WP_154075029.1\|345177_347595_+\|ATP-dependent-zinc-metalloprotease-FtsH	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NZ_CP045929.1\|WP_154075022.1\|327314_330224_+\|type-I-DNA-topoisomerase	gnl\|CDD\|236048	PRK07561, PRK07561, DNA topoisomerase I subunit omega; Validated.	0
NZ_CP045929.1\|WP_154075018.1\|321247_322867_+\|tannase/feruloyl-esterase-family-alpha/beta-hydrolase	gnl\|CDD\|284851	pfam07519, Tannase, Tannase and feruloyl esterase. This family includes fungal tannase and feruloyl esterase. It also includes several bacterial homologs of unknown function.	1.95089e-128
NZ_CP045929.1\|WP_154075019.1\|323222_325586_+\|sodium-translocating-pyrophosphatase	gnl\|CDD\|234827	PRK00733, hppA, membrane-bound proton-translocating pyrophosphatase; Validated.	0
NZ_CP045929.1\|WP_154075027.1\|343336_344353_+\|tRNA-lysidine(34)-synthetase-TilS	gnl\|CDD\|238950	cd01992, PP-ATPase, N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This domain has a strongly conserved motif SGGXD at the N terminus.	2.5012e-53
NZ_CP045929.1\|WP_154078535.1\|340293_341889_+\|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	gnl\|CDD\|200042	TIGR00666, D-alanyl-D-alanine_carboxypeptidase_DacB, D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family. In E. coli, this protein is known as penicillin binding protein 4 (dacB). A signal sequence is cleaved from a precursor form. The protein is described as periplasmic in E. coli (Gram-negative) and extracellular in Actinomadura R39 (Gram-positive). Unlike some other proteins with similar activity, it does not form transpeptidation. It is not essential for viability. This family is related to class A beta-lactamases. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	1.73805e-71
NZ_CP045929.1\|WP_154075020.1\|325720_326398_+\|hypothetical-protein	gnl\|CDD\|371145	pfam10577, UPF0560, Uncharacterized protein family UPF0560. This family of proteins has no known function.	0.0066798
NZ_CP045929.1\|WP_154075024.1\|332481_335022_+\|EAL-domain-containing-protein	gnl\|CDD\|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	3.66286e-101
NZ_CP045929.1\|WP_154075032.1\|349499_349994_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|223872	COG0801, FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism].	5.41769e-46
NZ_CP045929.1\|WP_154075031.1\|349143_349503_+\|dihydroneopterin-aldolase	gnl\|CDD\|224456	COG1539, FolB, Dihydroneopterin aldolase [Coenzyme metabolism].	9.11622e-44
NZ_CP045929.1\|WP_154078534.1\|330886_332113_+\|DNA-polymerase-III-subunit-delta'	gnl\|CDD\|236134	PRK07940, PRK07940, DNA polymerase III subunit delta'; Validated.	0
NZ_CP045929.1\|WP_154075030.1\|348305_349151_+\|dihydropteroate-synthase	gnl\|CDD\|238380	cd00739, DHPS, DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and protein biosynthesis. Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS. Sulfonamide drugs, which are substrate analogs of pABA, target DHPS.	1.78284e-111
NZ_CP045929.1\|WP_154078536.1\|342087_343197_+\|coenzyme-F420-biosynthesis-associated-protein	gnl\|CDD\|274833	TIGR03883, DUF2342_F420, uncharacterized protein, coenzyme F420 biosynthesis associated. A phylogenetic tree of the DUF2342 family (TIGR03624) consists of two major branches. One of these branches, modeled here, is observed almost entirely to be found in coenzyme F420 biosynthesizing species of the Actinobacterial, Chloroflexi and Archaeal lineages. The few organisms having genes within this family and lacking F420 biosynthesis may either have an undiscovered F420 transporter, or may represent F420-to-FMN revertants. This family includes a Chloroflexus Aurantiacus protein whose crystal structure has been determined (PDB:3CMN_A). This has been annotated as a putative hydrolase, but the support for that assertion is untraceable. There is no cofactor present in the structure.	6.91875e-128

>NZ_CP045929.1|WP_154075026.1|337736_338225_-|inorganic-pyrophosphatase
MEFDVTIEIPKGSRNKYEVDHKSGRIRLDRTLFTATQYPADYGFVDNTLGEDGDPLDALVLVQEPTFPGCLISARAIGMFRMRDEKGGDDKLICAPSDDPRQEHLRDIHHLSEFYKLEIQHFFEVYKDLEPGKSVEGATWVGRIEAEEEIERSYRRAKEHGH
>NZ_CP045929.1|WP_154075025.1|335816_336659_+|DUF4231-domain-containing-protein
MQSAEVSPGIVGGGVIPEGAPPQDLERRIAERSEKLYHVRLVQRILMIWAYPGNLVILGVSVASVAVLQQQLAVVVPLAVLVPAASLVASARALYRQHFRIRSVHTQLKSLRTEHEEHLLDELGVEDLLAAHKRYRSQLPDVIARYRVESRSCRRKHNAVQSVVIVGSILSAAATTASLSLADARVPAVVLSLLVAVSAAFGGYAKYRERSVNLQQTADALEREYESVELRVGRYRRFGTEREAYAEFAHEVETLRAEQAKRRQHWGQVFVDDDTAVVGR
>NZ_CP045929.1|WP_154075024.1|332481_335022_+|EAL-domain-containing-protein
MGSLWRGRVSLLGRVYVLVAVLLVLLGAVSVGTFVFRQWDEAVTIQLTTKVVPSQIAASGLAAAYSDQSNAVRDFQDTADPEFLGAYRIRRDEATRFGQIIDENMGGFPQVTSSLNDVREASRTWRRDSVAPMIEQVRSQGPSPLSPEEARTLSRQDEVLRAELADLQQRLNEIAADDTAKAGAARAAANWLTWSAVAASVVLAAGALLFLRRSLTRPLRKLVFQVDQVAEGDLDRPVGVVRPPELATVAHAVETMRKRVLDETSRRERVQQDLARHEAAERKRAEQDYATVVAALDEGVVVVGAEGTVAAVNPAAQRILDSDESELVDSSSVSWSVFDENGRLLTPEEHPTTVTQRTGEPVNSRVLRLRRGDGSDVWVSVTSRALTPREDPPHNVVVSFTDITERRAAQQRLEHEATHDPLTGLANRTLVLRHCDIRSDGDPLAILYLDLDNFKRINDSLGHGAGDDVLCVVGQRLLRTVAGENVVGRIGGDEFVVLVDESDRDVLAEFGERLLAVLTEPVDVRGRQLHVNASIGVVVASIGDARRGQDLLRDADVALYQAKARGGGRLTFFDVQLRERVQRHMALEQDLRHAASKDQLWVAYQPVVDLRTERTVAAEALLRWDHPAHGAVSPGEFIPIAEESDLIQHVGAHMLRTATRQFAAERDRLELDLQLNANLSPRQLRDPQLHTVVQHALAAAELPAEALCLEITEEAIMHDPAQATWVLNELRDLGVELAIDDFGTGYSSLAQLQRLPVDTLKIDRSFVSDLGESSDREAIVTSIIAMAHSVALTVVAEGVETARQLDLLAGLGCDKVQGYYLGKPAPFDELPTRNPLLRHRKSAQRR
>NZ_CP045929.1|WP_154078534.1|330886_332113_+|DNA-polymerase-III-subunit-delta'
MEGVVPPRSGVWSDVVGQPDAVRVLAAAAQAASSQVRGERSPAGAMTHSWLFTGPPGSGRSVAARAFAAALQCERTGPDEVPGCGDCSACRTVFAGTHADVRLVVPEGLSISVAEMRSLVQAAARRPTTGEWRVVLIEDSDRLTEGAANALLKAVEEPPDRTVFLLCAPSDHPEDVSVTIRSRCRVVRLRTPSADAIAEVLRERDGVEPETAEWAASVCGGHIGRARRLATDEQARDRRAAVLRIPLGMTRFADVFRAATGVVATAESEATAANEERNEAEKEELKTAMGAGGTGKGTASATRSANAALKELEKRQKSRTTRSQRDALDLALVDLAGFYRDVLVTRSGARTPLNHPDCDEQVSRAATEWTSESTLRRLEAVLQCREALSQNVKPIIAVEALAATLHRG
>NZ_CP045929.1|WP_154075023.1|330397_330748_+|hypothetical-protein
MRDALSGADGTQPLSAMQMFGDALSGAVRRATTSDVQETVEQQHEDAVQRLVERGAVPQQRRRASRHDESSAQAARLTASVPDAHGPTRRSSTVPQQNLVAQGRRELEVPSLRPYR
>NZ_CP045929.1|WP_154075022.1|327314_330224_+|type-I-DNA-topoisomerase
MAGSTRTKQNGTNGAGNARRLVIVESPAKARKIASFLGSNFVVESSRGHIRDLPRGAADVPAKYKGQSWARLGVDVDNDFEPLYLVTADKKPTVTELKDALKDVDELYLATDGDREGEAIAWHLMQTLKPKVPVRRMVFHEITESAIQAAAENPRDLDQDLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRVVVQRERERISFVSAHYWDLSATLDAGAEADPRSFSARLVSVDGAKVATGRDFGPDGQLKSADVRVLTEADARQLADGLASASLSVSSVEEKPYTRKPYAPFMTSTLQQEAGRKLKFSSDRTMRTAQRLYENGYITYMRTDSTTLSDAALNAARSQARELYGDSFVTKSPRQYTRKVKNAQEAHEAIRPAGENFRTPGEVASELDTDGFKLYELIWQRTIASQMADAKGTTLSVRITGTAEGGEQCTFAASGRTITFSGFLRAYVESVDSEAGGSADDAESRLPQLVQDQAITATELSPDGHSTNPPARYTEPSLVKAMEEMGIGRPSTYASIISTVQDRGYVWRKGSALVPSWIAFAVVGLMEKHFGRLVDYDFTAALEDELDGIAEGRQQRTRWLAGFYFGGDVGPDDSIGRAGGLKKLVGSGVEEIDAREINSIPMCTDEQGRTVYVRVGRYGPYLERVLGTKEDGTPESQRANLPDDLPPDELDIDVAEKLFATPMEGRSLGTDPETEHEIVAKEGRFGPYVTEILPEGDKSKPRTGSLFKSMSLDSMTLDDALKLLSLPRVVGDDPESGEQITAQNGRYGPYLKRGTDSRSLETEEQIFTVTVDEALKIYAQPKQRGRRAPAPPLREMGDEPDTGNALVIKDGRFGPYVTDGETNASLRKGDDVESITLDRAVELIQERRAKAPAKKKAPAKKKSTATKSTATKSTASKGSSSKGTASKSTATKSTASKSTASKSTSGRKTASTKKSTSSSSSAKASSTKSS
>NZ_CP045929.1|WP_154075021.1|326541_327126_+|hypothetical-protein
MDQLSFYSAEAQPPRIADLAGLLCAQGQAVGFGRGTAARLSVVVGEHWRAVSLVEACAERGVDAEVARSEGGHPLIRTAFRADLTALASSWLRGAVKAVPPTFAPHGNALRIWALASGHLEPGGYVLGLDPHAPDTHAPLLDALGRAGLPAKSLGVRGGGPALRVTGRRRIARLAELVGPVPNGAIERTWPWVS
>NZ_CP045929.1|WP_154075020.1|325720_326398_+|hypothetical-protein
MSIRTTSVAALAAVPLVLAGCSQQSQDQSQQAPQQPPAEQQQGQQEGQQGGQQDGVRWVGSLCGLIGGFAQSQQQGPQVDQSSPEAFKQSSIAQIDSAEQSANQTVSELQGLGPSPINGGDKLNSTFQEGFVQVTDVLRSAKGKAEQVDTSNEQAFTQGMTEVQNELKRGEQINFQEQFTEFDRNQELNQAAMQAQECQALMAPPQQPGQPPQQPGGAPQPPPGQ
>NZ_CP045929.1|WP_154075019.1|323222_325586_+|sodium-translocating-pyrophosphatase
MSLLFGVHGGWAQGAAPPESSGVRAASTDIALTGPDYAVVGVVIAIALGALAFGSVLTREVLAAGQGTVKMREIAQAVQEGASAYLNRQFRTLAVFAVAVFLVLFALPAETLSERIGRSIFFLFGAAFSAVIGYLGMWLSTRANLRVAAASTEDGGREKAMRVAFRTGGVVGMTTIGLGLLGAALVVLVYAGQAPRVLEGFGFGAALLAMFMRVGGGIFTKAADVGADLVGKVEHNIPEDDPRNAATIADNVGDNVGDCAGMAADLFESYAVTLVAALILGTAAFGLQGLLFPLIVPAIGVLTAVIGVYITKARSGESALTAINRSFYISAGISGVLCAIAAVLYLPGSFAGLTGVSDEVRAIDGSPALIALVAVIIGILLAVVILKLTGYFTATEHRPVRDVGESSLTGPATVILTGLSVGFESAVYTALVIGVAVFGAFLLSSTLSVALFAIALAGCGLLTTVGVIVAMDTFGPVSDNAQGIAEMSGEVEGESANILTELDAVGNTTKAITKGIAIATAVLAATALFGSYLDAITAALVGAGQQFLAGDFVVYAPNVLVGVVIGASVVFLFTGLAINAVSRAAGAVVYEVRRQFSANPGIMDGSTRPEYGRVVDICTRDSLRELATPGLLAVLAPIAVGFGLGVGPLAGYLAGAIATGALMAIFLANSGGAWDNSKKLVEDGYHGGKGSDSHEATVIGDTVGDPFKDTAGPAINPLLKVMNLVSVLIAPAVVALSVGDAASPALRIGIAVVATAVIVGAVVLSKRRSTAIAGTSAEQGAVTNGAS
>NZ_CP045929.1|WP_154075018.1|321247_322867_+|tannase/feruloyl-esterase-family-alpha/beta-hydrolase
MRAGRTTTIGLVLAVAMSVPATGAADPPRCEDLREVAVPGRVMGLPTSGGEVLDARTVAASGPIGEHCRVTGAIHPVDPSAPDIVFELALPSEWNHRALMFGGGGYNGTVPAVEGTLPFGPPGDAGPLASGFATFASDSGHQAAPDHEPTPSLDGSFGVNDEALRNFAGDALKKTRDAAMYLLRQHYRVKPDRSYFAGGSTGGREGLAVAQRWPGDFDGVISAYPAWNAASLDLFFGHMARALAAPEAFLDERDQALLYDSVVRACDGLDGATDGVISDAVGCDFDPKVLRCESGDGEGCLTPAQIEAARAISSPLEFGYPVASGETGYPGFPVLSGANMNAGVLGFGTTAPAEPMPTDAAYGAQFWDQWVRHFVTRDPDFGSLGLDPTRPGPWRERISELTALQDVNEVDLRPFARRGGKLLLVHGTADQLVSHRSTIDYYQRMMSAMGAEAVEDFSRLYLVPGADHANANAAFAAGWDSLGALQRWVEGGHAPHDEVVTDVNPDARQRTRPLCEFPTWPRYDGTGSVDEAGSFSCVD
>NZ_CP045929.1|WP_154078535.1|340293_341889_+|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase
MAGLPSEPDPPTSRISRGSLPADIGPETQRIPALPPDSGTAGQPTPDPADEAFQGQVDQGVESGAPEGESRGGVRRGLLVAALATVVVLVAGVVFGVAQFGGPTIAEPPPPVQLRPSITPVGSSAPAPTPSGTESALAQAASNPALGTLGGVVVDTRSGERLWASQPGTPLVPASTTKVVTASAALLALDPQHRFTTKVVQGESPGSVVLVGGGDPTLSSLPRGAESVYPGAAHMDDLAAQVERATGGSVSSITVDTSRYAGPPQASGWLPEDVAGGFVAPMEPVMVDGGRADPTEDTSPRSAEPALDAGRELGALLGVDASAVGTGTAPQSGSAPGTVLGQVRSATVQDMVETVLQRSDNVLAEALAREVAVASGRPASFDGATSAVRDVLAGNGIDLTGVTLSDASGLSTDNRITPEVLGSLITNASAAPGADGLPEASRKLRALLPGLPVAGGSGSLAERYRSENTEGRGWVRAKTGTLTGANSLAGTVVTRDGRLLAFAFMSNGTPTEFARPALDNLAATLRECGCR
>NZ_CP045929.1|WP_154078536.1|342087_343197_+|coenzyme-F420-biosynthesis-associated-protein
MRGDGAGRAGPGTLDWDTAVATATRLVQPGPPGVSREVADRAVRALREYSLVAETHVRELTDLGHELPVRHGDVVDRPGWIRSAAGGLAELTDIATRHAQRDDDTDESAVTALLGGVGRQGAGLQAGVVLAYLGAKVLGQFDPFVPGPDGSADGRLVLVAPNIVAAQQALDVPADDFAMWVCLHESTHRLQFTAVPWLRDYFAASLAELMSEMDGTATELAGRLPAVVKQVRAGREGDSSPGMLGIVELVQSPRQRAAFDRIIALSTLLEGHADHVMDAVGPEVVPSVRTIRDRFTRRRQGGGLLDRVLRSLLGVDAKIKQYAQGAAFTDRVVDVVGMEGFNAVWTAPENLPSRAEITSPDSWVRRVHG
>NZ_CP045929.1|WP_154075027.1|343336_344353_+|tRNA-lysidine(34)-synthetase-TilS
MLGDTEVVPSPDPAVSAVRSAVRRFLASADAVPFAEAPLVVACSGGADSLALAAAVAHVAPRRVRALVVDHQLQAGSAEVAARAAEQVRRMGCEDVRVCRAEVRGPGGAEAAARRARYDVLSQESPDDALVLLGHTLDDQAETVLLGLGRGSGPRSIAGMRPLSPPWARPLLDTSRVTTRKACSALGLEPWDDPHNVDPTFTRARLRGEVVPLLEEVLQGGVAEALARTAAQLQDDSDALDALGSRLRGEAHVRDELDTEVLAAWPAAVRRRALREWLYARGVPELDDRHLRAADALVGRWRGQGPHALPGGFELRRAHGRLRVDDGGHACTAGATGG
>NZ_CP045929.1|WP_154075028.1|344384_344942_+|hypoxanthine-phosphoribosyltransferase
MYDGDIASVLITEQQLRDKISEIAQKVDSDYEDVHTSDLVLIGVLKGAVMFMTDFARALGRSTQLEFMAVSSYGSSTSSSGVVRILKDLDRDIAGRHVLVVEDIIDSGLTLSWLLKNLESRNPASLEVCTLLRKPDAVQVEVPVRYVGFDIPNEFVVGYGLDYAERYRDLPYIGTLDPKVYTSGR
>NZ_CP045929.1|WP_154075029.1|345177_347595_+|ATP-dependent-zinc-metalloprotease-FtsH
MDRKRLLRNPLLWFLAVLLLFYTFNVLFDDTRGYAEVSTARALEQIDQGRVAEVTIEDKEQQLRLTLNEGEQIDGSNRLIAQFPAGSTDGIVQEIRGAQINNWNTEVTQDSFLMQMLIYLIPLGLLLLLLLWMMNKQGGGNRIMNFGKSKAKQFTKDMPKTLFGDVAGADEAVEELHEIKDFLQYPSRYQALGAKIPKGVLLYGAPGTGKTLLARAVAGEAGVPFYSISGSDFVEMFVGVGASRVRDLFEQAKQNAPCIVFVDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGFDSNASIILIAATNRPDILDPALLRPGRFDRQIPVSPPDMAGRRAILGVHTQGKPLAPDADVEGLAKRTVGFSGADLENVVNEAALLTARENGQLITSAALEESVDRVIGGPRRKSKIISDRDKKITAYHEGGHALAAWAMSDLDPVYKLTILPRGRTGGHALVVPEDDKDMMTRSEMIARLVFAMGGRTAEELVFHEPTTGASSDIEQATKIARAMVTEYGMTARLGAVKYGKEEGDPFVGRSAGQQPNYSLEVAHEIDEEVRKLIETAHTEAWEILNTYRDVLDNLVLEVIEQETLNRTELERIFAKVSKRPRITAFDDFGGRTPSDQPPVKTPGELAKERGEPWPPPEQQPAPVGGTNGSAPQGQLPPGQPPQVQSPQGQPYPQGQPYPQGQSAPQGQPSPQQSGQDQGTVQVPQTNQDPSAQTGGPSAPRAVPPNYGAPPGWTPATSPGSRDTQHSWVPSWERPQNHQAPTPQPGQVAADPNRPQGEQNGSADESQREDPDSRNQ
>NZ_CP045929.1|WP_154078537.1|347697_348306_+|GTP-cyclohydrolase-I-FolE
MEQDHLDRFDVSRPEFDHDRAQAAIRELLLAAGEDPDREGLVETPERVARAYQELFAGLYTDPDEVLDRTFDESHEELVLVRDIPMYSSCEHHLLPFHGMAHVGYIPNDQGRVTGLSKLARLVDLYAKRPQVQERLTSQIADALARKLEPRGVIVVVEAEHLCMGMRGVRKAGSTTTTSAVRGIFRSSASSRSEALSLIRGR
>NZ_CP045929.1|WP_154075030.1|348305_349151_+|dihydropteroate-synthase
MHALLPRPERSVVMGVLNVTPNSFSDGGRYLDQRDAVEHGVEMHRQGADLVDVGGESTRPGSDRVAAEEESSRVLPVVRDLVAAGVPVSVDTTRAQVARATVEAGASMINDVSGGLADPDMAKVAAELGVPWVLMHWRGHSKDMNALAEYHDVVTEVRDELSRQVDVALAAGVEQEAIVLDPGLGFAKRAEHDWALLRHLDVVLGMGFPVLVGASRKRFLGALLAEEDGTPRPAEQRDGATAAVSVLAADHGAWGVRVHDVSGSLDAVRIAAAWRRGGARG
>NZ_CP045929.1|WP_154075031.1|349143_349503_+|dihydroneopterin-aldolase
MGDRITLTGLRVRGYHGVFDHEKRNGQDFVVDVTAWLDLGPAARSDQVEQTLHYGELAEQVAGIVAGPSRDLIETVAGEVADHVLSDSRVAEVQVTVHKPTAPIALEFADVAATIHRSR
>NZ_CP045929.1|WP_154075032.1|349499_349994_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MSRAVLSLGSNLGERLEHLRLAVHGFGEDVVVTSAVYETEPWGVRDQPRFLNAVIVVAADGLDEWGWLRRGQALEAQAQRRREQRWGPRTLDVDVVTVDGVHSDHPDLVLPHPGTPSRASVLVPWLEADPEAVLPGHGPVRDLAAALSKEERDTLHRRPDLPLH
>NZ_CP045929.1|WP_154075033.1|350120_350693_-|hypothetical-protein
MDEERNRMIDEFWDEVSEGLNVNPEFIAWMRSAKPNLPENASTEQVEAWIELADLVSDRSFRDLVRGMNAEQAALRDGGEEDAQQPQQLAEEAWEVQEAVAQAHREGTPADSPRAVELAGQFATTFADHKGKADTPELREEIAGHFESHDSRLSRYWVLLATINGWPQQKGILDDAASKWLAAALRASLR

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Crispr_ID: NZ_CP045929_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045929_2

442837-442997

Orphan

Consensus_repeat	Method
TTGAGGCGAACGGCACTTTCGCCTCGTGTGGTGAGGCGAAAGTGCCGTTCGCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP045929_2

>merge|NZ_CP045929|2|442837-442997|CRISPRCasFinder
TTGAGGCGAACGGCACTTTCGCCTCGTGTGGTGAGGCGAAAGTGCCGTTCGCTCCAGCTCGGGTGTGGTTCAGCGGGTGTGGGTCGTTGAGCGAGTGCGCCGATCCGGTTGAGGCGAACGGCACTTTCGCCTCGTGTGGTGGGGCGAAAGTGCCGTTCGCT

>NZ_CP045929|2|2|442837-442997|CRISPRCasFinder
TTGAGGCGAACGGCACTTTCGCCTCGTGTGGTGAGGCGAAAGTGCCGTTCGCT	CCAGCTCGGGTGTGGTTCAGCGGGTGTGGGTCGTTGAGCGAGTGCGCCGATCCGG
TTGAGGCGAACGGCACTTTCGCCTCGTGTGGTGGGGCGAAAGTGCCGTTCGCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045929.1\|WP_154075112.1\|431154_431517_-\|transposase	unknown	unknown	gnl\|CDD\|225511
NZ_CP045929.1\|WP_154075119.1\|440396_441116_+\|ESX-secretion-associated-protein-EspG	unknown	unknown	gnl\|CDD\|379414
NZ_CP045929.1\|WP_154075127.1\|449763_449964_+\|sulfur-carrier-protein-ThiS	unknown	unknown	gnl\|CDD\|340451
NZ_CP045929.1\|WP_154075113.1\|431556_432099_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045929.1\|WP_154075128.1\|451003_452986_-\|FUSC-family-protein	unknown	unknown	gnl\|CDD\|224208
NZ_CP045929.1\|WP_154075123.1\|445123_446260_+\|S1-family-peptidase	unknown	unknown	gnl\|CDD\|367281
NZ_CP045929.1\|WP_154078543.1\|432848_433871_-\|ADP-ribosylglycohydrolase-family-protein	unknown	unknown	gnl\|CDD\|377122
NZ_CP045929.1\|WP_154078545.1\|449974_450742_+\|thiazole-synthase	unknown	unknown	gnl\|CDD\|234687
NZ_CP045929.1\|WP_154075121.1\|443012_444074_-\|SIS-domain-containing-protein	unknown	unknown	gnl\|CDD\|223526
NZ_CP045929.1\|WP_154075115.1\|434157_437031_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276938
NZ_CP045929.1\|WP_154075114.1\|432123_432420_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045929.1\|WP_154075116.1\|437315_438116_-\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238870
NZ_CP045929.1\|WP_154075129.1\|453142_454078_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|180561
NZ_CP045929.1\|WP_154075118.1\|440076_440397_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045929.1\|WP_154075124.1\|446485_447601_+\|trypsin-like-serine-protease	unknown	unknown	gnl\|CDD\|365866
NZ_CP045929.1\|WP_154075120.1\|441227_441887_+\|DUF3159-domain-containing-protein	unknown	unknown	gnl\|CDD\|371490
NZ_CP045929.1\|WP_154075125.1\|447832_448504_-\|thiamine-phosphate-synthase	unknown	unknown	gnl\|CDD\|234590
NZ_CP045929.1\|WP_154075122.1\|444187_444946_+\|UTRA-domain-containing-protein	unknown	unknown	gnl\|CDD\|225099
NZ_CP045929.1\|WP_154075126.1\|448696_449767_+\|glycine-oxidase-ThiO	unknown	unknown	gnl\|CDD\|274092
NZ_CP045929.1\|WP_154075117.1\|438134_438467_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP045929.1\|WP_154075112.1\|431154_431517_-\|transposase	gnl\|CDD\|225511	COG2963, COG2963, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	4.42226e-12
NZ_CP045929.1\|WP_154075119.1\|440396_441116_+\|ESX-secretion-associated-protein-EspG	gnl\|CDD\|379414	pfam14011, ESX-1_EspG, EspG family. This family of proteins contains the the EspG1, EspG2 and EspG3 proteins from M. tuberculosis. These proteins are involved in the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis which is important for virulence and intercellular spread. Proteins in this family are typically between 254 and 295 amino acids in length.	1.09936e-34
NZ_CP045929.1\|WP_154075127.1\|449763_449964_+\|sulfur-carrier-protein-ThiS	gnl\|CDD\|340451	cd00565, Ubl_ThiS, ubiquitin-like (Ubl) domain found in sulfur carrier protein ThiS. ThiS, also termed Thiamine biosynthesis protein (ThiaminS), is a sulfur carrier protein involved in thiamin biosynthesis in prokaryotes. It has the beta-grasp ubiquitin-like (Ubl) fold with low sequence similarity to ubiquitin (Ub), and is activated in an ATP-dependent manner by sulfurtransferases, similar to the activation mechanism of Ub-activating enzyme E1. ThiS has common evolutionary origin with Ub-related protein modifiers in eukaryotes, a beta-grasp fold as Ub, and is closely related to proteins MoaD and Urm1.	5.10371e-18
NZ_CP045929.1\|WP_154078543.1\|432848_433871_-\|ADP-ribosylglycohydrolase-family-protein	gnl\|CDD\|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	5.27399e-41
NZ_CP045929.1\|WP_154075128.1\|451003_452986_-\|FUSC-family-protein	gnl\|CDD\|224208	COG1289, COG1289, Predicted membrane protein [Function unknown].	1.63163e-13
NZ_CP045929.1\|WP_154075123.1\|445123_446260_+\|S1-family-peptidase	gnl\|CDD\|367281	pfam02983, Pro_Al_protease, Alpha-lytic protease prodomain.	4.0922e-09
NZ_CP045929.1\|WP_154075125.1\|447832_448504_-\|thiamine-phosphate-synthase	gnl\|CDD\|234590	PRK00043, thiE, thiamine phosphate synthase.	5.30996e-78
NZ_CP045929.1\|WP_154075121.1\|443012_444074_-\|SIS-domain-containing-protein	gnl\|CDD\|223526	COG0449, GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell envelope biogenesis, outer membrane].	3.40125e-61
NZ_CP045929.1\|WP_154075115.1\|434157_437031_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	1.07869e-33
NZ_CP045929.1\|WP_154075124.1\|446485_447601_+\|trypsin-like-serine-protease	gnl\|CDD\|365866	pfam00089, Trypsin, Trypsin.	9.95644e-10
NZ_CP045929.1\|WP_154075116.1\|437315_438116_-\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238870	cd01832, SGNH_hydrolase_like_1, Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid. Myxobacterial members of this subfamily have been reported to be involved in adventurous gliding motility.	1.09089e-71
NZ_CP045929.1\|WP_154075129.1\|453142_454078_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl\|CDD\|180561	PRK06427, PRK06427, bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed.	1.75048e-118
NZ_CP045929.1\|WP_154075126.1\|448696_449767_+\|glycine-oxidase-ThiO	gnl\|CDD\|274092	TIGR02352, Glycine_oxidase, glycine oxidase ThiO. This family consists of the homotetrameric, FAD-dependent glycine oxidase ThiO, from species such as Bacillus subtilis that use glycine in thiamine biosynthesis. In general, members of this family will not be found in species such as E. coli that instead use tyrosine and the ThiH protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine].	2.46959e-90
NZ_CP045929.1\|WP_154075120.1\|441227_441887_+\|DUF3159-domain-containing-protein	gnl\|CDD\|371490	pfam11361, DUF3159, Protein of unknown function (DUF3159). Some members in this family of proteins with unknown function are annotated as membrane proteins however this cannot be confirmed. Currently this family of proteins has no known function.	3.07553e-48
NZ_CP045929.1\|WP_154075122.1\|444187_444946_+\|UTRA-domain-containing-protein	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	4.02887e-74
NZ_CP045929.1\|WP_154078545.1\|449974_450742_+\|thiazole-synthase	gnl\|CDD\|234687	PRK00208, thiG, thiazole synthase; Reviewed.	1.82706e-148

>NZ_CP045929.1|WP_154075120.1|441227_441887_+|DUF3159-domain-containing-protein
MSAQRSSQVAPGEPESLTTLLGGRTSAIDASLPPVAFGLAWWLSGQSVLVAGVAAVLVGLILAVWRLVRGARPAAVLVSLLAVLVGAVIAVRTGQAVDFFLVRLLSNAASAVAFAVSVAVRWPLLGVVVGTVLRQRTRWRRDPALLRAYGRASWVWVGQYLVRLVVFIPLWAANSVLGLTVAQVVLTWPLVALCIAVSWWVLRRSLPAEHPGIRHPQVD
>NZ_CP045929.1|WP_154075119.1|440396_441116_+|ESX-secretion-associated-protein-EspG
MVDTITLSIPAVDVLGEHLDLNLRQFPFEIPRPADDQERERVAVLVRDELETAGLTRSGRPEPELEDALYLLCSSEVAIAVSGLLDVRTGHRLAARVVATGEVGVLGLLDRGNLRLNFLAPDELPSAAVGLLPDAPAGSGSAVSAPLARPGEPTGEASADLAALTSRPKFRVGQFGVSAGGRRGQRSRLPGLTWFDTDRGRYSMSTEPRPDGQYLVAAPADGARLVGLLGSMLTLAQGR
>NZ_CP045929.1|WP_154075118.1|440076_440397_+|hypothetical-protein
MPAPKPLAYQPRDDGGFGPKGSGSWGSGGTRSRRQGRNSALAGDEVTEADARGHEFSTGGYRPEEGTGKGPQFLVEADDVYDEEYGESRLVAPPVLGEAPPSFRDF
>NZ_CP045929.1|WP_154075117.1|438134_438467_+|hypothetical-protein
MNHRPRRPQSGAAISGHPGEASSTYATVGYGRVGSAHGTEIVGEGASSQRDEAVLDVRMLIVRPAAATYRDQRHERTSFSRCGGKPPLSSVSARAAGGSRKTAITAAGSC
>NZ_CP045929.1|WP_154075116.1|437315_438116_-|SGNH/GDSL-hydrolase-family-protein
MRRNGVPEHPWRSLVALGDSFTEGMDDPGPDGGVRGWADRLAERLDAGTSGFRYANLAVRGKLLHQVIEDQVPRAVSAEPDVVALTAGGNDLIRPSGDPDALAAQLDHAVATLRASGAQVLVGTGFDPRERPVMRRVRGRVGTYNSHVHAIAAHHGCLVLDLWSMPVLQDSRAWSDDRLHLAPEGHRRVALRACEALGVPVDADWREPLPPGREQTWQVQRAGDLHWVRHHLAPWIGRRLQGRSSGDGRRPKRPDLRELVPGSEGR
>NZ_CP045929.1|WP_154075115.1|434157_437031_+|tetratricopeptide-repeat-protein
MAPQESSTTAPSTGFDFRVLGPLEVLHDAEPQRLGRPRVRATLACLLLEPNQVVSMDRIIETLWGDEPPASARTIIHGYISRIRKLFAEKDDGAPDDVPQVVTRPPGYLIRLDSDRVDAHRARALVNHAQHLEPEERSRVLTDALTLWRGPVLQDIDSERLHRTVVPNLDELRLLALEERIDADLACSRHQSLVVELSTVVDEHPLRERLAGQLILAHYRSGHRAEAQARYHALREKLSHELGIDPGPELRKLYDLLLRDDDSLLTGEQRRQGSAAAPAPAAYVARPVPAELPPAPAGFVGRLPESAALDAMVEQDTGTPNRLAVLTGTAGVGKSALAITWSHRVAHRFPDGQLYASLRGFDSERTPLSPAEALTSILKTLGVAADAIPVGLDDRAALYRSLLADRRVLVLLDNARDSEQVRLLLPAGTKSLVVITSRRRLDGLVVGSGAEVLPLETLSTDVAVELLDRAGIPGRSTSEPAATRRLAELCGGLPLALRIAAARLAVSPGRGAGDLVDELTDERDRLHAFDVEDADTSVRRAFDISYRSLHATHASTFRMLGLVPGHTFTPHVVAALCGTEPAGARRRLRALALAHLVTEPEPDRFGMHDLLRLYARDLVADEHRPAAGDESALRRLVHYYMVVADRARRFLRPPRDSLDFTADTETVSPVIGSRAQALEWFDAEWPNLVATIRVLNARGMHELCWPLVRLQFNYVMVRCPWEDWIQIYTDGLDSARAVDDTVGSLLMSAGIGVAYSRSQRPAQALPHYAESYRGALAGGDPGWQAMAQVNMGAVLVRLERYDEARGYCWDALQTYRTLGDRYRQAGALNNLAQTEQAAGRREEALSHLVEAEAMCREADDLETLAVVLSNCGEVSLDLGRAAEAERYHHEALDVALRCGSAMRQASAYVGLGDAATARGDRAVARTRWETALGILETVASRRAGEVHKRLDEFVEHH
>NZ_CP045929.1|WP_154078543.1|432848_433871_-|ADP-ribosylglycohydrolase-family-protein
MVDRAIGCLLGGALGDSLGAPVEFQPLDDIHAEYGAAGISEPPPQALLGDATQLTLFTGEGYLHAWTSGNHGRRWDPVGSVAAACQRWLTTQQDDGPAPGATGLLAEAELYANRSPGITTLRALGEGHFGSPDDPANTSQGCGGLDRAAPAGFAPGPELAFELGCRFGALTHGGTGGWASAGAHAMLVHLVAVQGRRLPAAIDQATGRVLREDERTAHALAEASTLARLGASVGHVERLGQGWVGPEALAIGAYCALALPKADEFADAVRLAANHSGHSDSTAAITGALLGARHGTAALPRDWLKRLELADVVERIAHDLGASCSGEAFNERRYLGFAHA
>NZ_CP045929.1|WP_154075114.1|432123_432420_+|hypothetical-protein
MRNNDPWKMAARWGLALIMFGFFMYWSVFLASLVGWSLEPRGLERITARWHILLLSVLAGLLAVISARAVLRFRLLTSWLVLAVAPACYFAVVESGAV
>NZ_CP045929.1|WP_154075113.1|431556_432099_+|hypothetical-protein
MIHLSPDWWYTGDDREVGYNTGKYRTRAVSNMLWLDAETLSSKDVAPNNRYERTDDGQYRYDSTRQADSDGLQVRALSNDGDYARNVIEHEVGMPYCNPVAGITYANQQDVYQNNGHWIYGSHDKMPDHQFYRVDFIQQDPNDPGSPIIEERDLVFHHELEDPTCLVGPVCGSWRYQYVR
>NZ_CP045929.1|WP_154075112.1|431154_431517_-|transposase
MPEKRRKFSPQFKAEAVQLVVATGRPVAEVARELQINEGTLGNWVNTWRRENPEPEPEMSPVERARLSELEAEVQRLRMENEFLKKAASGKHTAGIRRVEFGHVRATGSCTRAQHDLNHR
>NZ_CP045929.1|WP_154075121.1|443012_444074_-|SIS-domain-containing-protein
MPEAADEANARPGAHMSAEIAAQPQMFADLLAAHAAVAEVAARITERRPRFVLLAARGSSDHAALYAKYLTEVLLELPAGLVSASSTTLYGARPDLREVLVITVSQSGGSPDLVEVTRTARECGATTVAVTNTPHSQLNTVAELSVDVRAGAEQAVAATKTYSATLLSLYLLVDAVRGGSGAAAASVPDLASSTLESTRTGVEDAVARYRFADEIVTTGRGYSLATASEAALKLAETSYVSARSYSGADLLHGPVAAVDADTAVLAMISSGHGGGAMREVLEAVHARDADLCAIGSAARTVGASHRIEIPECAEELAPVLEVLPVQRLALGLALAKGEDPDHPRGLRKETRTR
>NZ_CP045929.1|WP_154075122.1|444187_444946_+|UTRA-domain-containing-protein
MLDPSAAGGADAPSRPPREPKYWGLKQHLLDRVRSLPAGSPIPTERALAAEFDVSRTTVRQALAELTVEGRLVRVQGKGTFVAAPKVAQPLQLTSYTQDTLSQGRRPASRLLDIVEEPADEQLARLLGVGTDGMVLRMRRLRLADGEPMAIETTHLPLPRFRGLGALLAAGGSLYRLMQERFDVELGHADETIETALATPEETELLGADTGLPMLLLSRHVFDAGGTTVEWVQALYRGDRYKFVARLDPPHG
>NZ_CP045929.1|WP_154075123.1|445123_446260_+|S1-family-peptidase
MARRFVVRAAGTVIVAAGTVAALTMPATADQSSETSTTIPVEPSRLQAMQRDLGLTPQQAEQRLAGEAKANAADAALRDSLGAAFGGSHFDAETNRLVVGVTDAGRTNEVRAAGADAVVVDDSKRELDATADALSRHSDAASDGVTGWYVDSKSNQVVVTTAVGTAAEAAEFVRSSGADTSSVDVVESAESPRTYANVYGGDAYYMGSGGRCSVGFAVNGGFVTAGHCGTTGTSTSEPSGTFAGSSFPGDDFAFVRITAADVTQPLVNMYNGQGRAVSGSQEAAVGASVCRSGSTTGWYCGSIQSKNQTVRYPQGTVYGLTRTNVCAEPGDSGGSFISGNQAQGMTSGGSGNCSIGGTTYFQPVNEALSRLGVSLKTY
>NZ_CP045929.1|WP_154075124.1|446485_447601_+|trypsin-like-serine-protease
MRRRLAARLAGSVFLAAGVVGAFTVPATANPTETMPQGALDAMQRDLGLTADQAEQRIAQEAVANDAFATLSSSLGQTYGGSHFDAATGKLVVGVTDQSAFDQVRAADATPVLVDDSERHLNATADALSAAADRQPEGVTGWYVDPASNQVVLTTAFGTAADAAGFVESSDADATSVDVVESAEQPRLLEDVIGGNPYFIGSGSRCSIGFSVEGGFVTAGHCGSTGDSTSQPSGTFAGSSFPGDDHGYVEVSSATPVGQVNDYSGGTVAVAGSQESAVGSSVCRSGSTTGWYCGTIEATNQSVSYPQGTVNGLVRTDVCAEPGDSGGSFISGDQAQGMTSGGSGNCSLGGTTYYQPVNEALDVYGLTLVTG
>NZ_CP045929.1|WP_154075125.1|447832_448504_-|thiamine-phosphate-synthase
MPGLDGHGIRARLDDARLYLCTDARTERGDLAEFADAALAGGVDIIQLRDKSPHGAPLEARHELAALEVLAEACVRHDKLLSVNDRADLALAVEADVLHLGQDDLPVGLARRVVGDRIVVGRSTHDVAQADSAATESGVDYFCAGPVWTTPTKPGRPAAGLDLVRHAAEHSGHGRPWFAIGGIDLDTVSEAREAGAQRAVVVRAITEAEDPAAAAEALRAALS
>NZ_CP045929.1|WP_154075126.1|448696_449767_+|glycine-oxidase-ThiO
MSQQRSHRVAVVGGGVVGLSVAWRAASSGSRVRLVDPAVGSGASWVAGGMLAPIAEAWPGEEELLTLGADSLARWPAFAEDLAADSGRPSGLRRDGTLVVGVDSADRAELTRLEEHLSSVGRTVTRHPGRELRRLEPALGPAVRAGLEVPGDLAVDNRVTLAALRDACRARGVEFVAESARAVSPGTVELNEGSLTCDVAVIACGAHSGSLHPKLDGRLRPVKGEILRLRHRGSALPPPRRTIRGPVHGRQVYLVPRDDGIVVGATQYEVGFDTDVTAGGVRDLLADAEQLVPGLSEYAVDEVTAGLRPGTDDNLPIVETLEPGVVATTGHHRNGYLLAPLTAETAVELLQDGGRT
>NZ_CP045929.1|WP_154075127.1|449763_449964_+|sulfur-carrier-protein-ThiS
MTITINGADHGVEADSSLATILAAYGVAEKGVAVAVDGAVVPRASWQDTIVPDGAAVEVLTAVQGG
>NZ_CP045929.1|WP_154078545.1|449974_450742_+|thiazole-synthase
MDPTEPLVIAGRKFDSRLITGTGGASNLAVLERALVASGTELTTVAMRRSDAEGRSGVLDLLGRLGIDVLPNTAGCRSAAEAVLTARLAREALETNWVKLEVVADDDTLLPDPAELLDAAEQLVDDGFVVLAYTNDDPVLARKLEEIGCAAVMPLGSPIGTGLGIRNPHNIEMIVSRASVPIVLDAGIGTASDAALAMELGCDAVLLATAVTRANDPERMATAMRSAVHAGHLAAHAGRIPQRFWAHASSPDRDT
>NZ_CP045929.1|WP_154075128.1|451003_452986_-|FUSC-family-protein
MAVSLMKDVYRRLATRTGAPDPRQHQYTTMVVVAAVAATVAGWVFDLRTLGLVAGLTAVFALVGAGGQSLRADLHRFAWFVPAVTLVMAVGPLLRSVPVLAGLLVAAVVFGAGMLPALGEHYRLVGQTFAAATLVSTTTGIGTDQPAALLFAAAGAGALFALALRVIIGLSDPTRWTRNAVALTLTEPGPGVVERAATAWRNDGAATWLGQVLAGASRFRAARETLLAQAGRADRAEAEQLRRIVAEADRIASELAVSVRAKACTGLPPEARRDPAAAVLEGGRQELPTAVRGINQGLDRIRAAVQERSEISATPEARIGRWERAKGAAKAHLSLRSSLFRHALRCTLAVGAGMVIVLLLSDPSASTLLLGLYVVLQPAARDSMTGALERTGGAVLGVVALAVVITLVPGTFLFVPLVIMGMMLRADRMRSDYQVLLGALITVTVVHQAMELGRPLANVAISFAGNTAVGAAIALIVGYVSYLVLPGSVVPNVRGSVRSTVWAVSELLRSVRAAGRGADLREALQSAHVLALRRTQDLLGMPALIDGTAAETEDREATRDAAIALDALRQDVASLAFRPEKERAVATPALQAVDALLGGKHEARIPDVPTGSAPATELLASSMLENALHARGAIDRALGHDDPWKSYTVSFVRPERHRIR
>NZ_CP045929.1|WP_154075129.1|453142_454078_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MHEPQGPRGRAHTSPFGGHVGPSAPAAPGTHTVAPAHDAAPPTALTIAGSDSGGSAGMHADLRTFFSCGVHGMTAVTAVTVQNTVGVTGLVEIEPAVVAAQIDAVASDIGVDAAKTGVLASAATIEAVVEMADKHGFGRGGRTPFVIDPVAASRSGEPLLHEDALDGLRHDAFPRATLVTPNLDEVRLLTGIEARTRADLWDAAKAIHDFGPEWVLIKSGHLPDDPECVDLLFDGEQALDLVGPRYTTEHTHGAGDAFASAITAALARGASMPDAVRCGKRFVTRSVEHAYPLGAGVGPVSTFWRVSSRSI

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Crispr_ID: NZ_CP045929_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045929_3

960204-960293

Orphan

Consensus_repeat	Method
TCACCGGGGCGTTGTGGTGCGAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP045929_3

>merge|NZ_CP045929|3|960204-960293|CRISPRCasFinder
TCACCGGGGCGTTGTGGTGCGAAGGGCACGTTCGCCTCGTCTGGTGAGGCGAAAGTGCCGTTCGCTTCACCGGGGCGTTGTGGTGCGAGA

>NZ_CP045929|3|3|960204-960293|CRISPRCasFinder
TCACCGGGGCGTTGTGGTGCGAAG	GGCACGTTCGCCTCGTCTGGTGAGGCGAAAGTGCCGTTCGCT
TCACCGGGGCGTTGTGGTGCGAGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045929.1\|WP_154078615.1\|963634_965353_+\|BCCT-family-transporter	unknown	unknown	gnl\|CDD\|376718
NZ_CP045929.1\|WP_154078617.1\|967965_968775_+\|DUF3152-domain-containing-protein	unknown	unknown	gnl\|CDD\|371483
NZ_CP045929.1\|WP_154078616.1\|966705_967659_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|184875
NZ_CP045929.1\|WP_154078614.1\|960335_960626_-\|DUF4873-domain-containing-protein	unknown	unknown	gnl\|CDD\|374407
NZ_CP045929.1\|WP_154075506.1\|952547_952724_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045929.1\|WP_154075508.1\|957253_958018_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045929.1\|WP_154075513.1\|965852_966488_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP045929.1\|WP_154075514.1\|968971_970150_+\|adenylyltransferase/sulfurtransferase-MoeZ	unknown	unknown	gnl\|CDD\|181156
NZ_CP045929.1\|WP_154075511.1\|961495_962395_+\|diiron-oxygenase	unknown	unknown	gnl\|CDD\|378680
NZ_CP045929.1\|WP_154075504.1\|949482_950712_-\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|240533
NZ_CP045929.1\|WP_154078612.1\|955930_956962_-\|DUF3068-domain-containing-protein	unknown	unknown	gnl\|CDD\|371444
NZ_CP045929.1\|WP_154075512.1\|962519_963464_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP045929.1\|WP_154075503.1\|945145_949258_+\|DUF3367-domain-containing-protein	unknown	unknown	gnl\|CDD\|378735
NZ_CP045929.1\|WP_154078613.1\|958482_958710_-\|DUF3107-family-protein	unknown	unknown	gnl\|CDD\|378634
NZ_CP045929.1\|WP_154075515.1\|970327_971128_+\|TIGR02569-family-protein	unknown	unknown	gnl\|CDD\|131620
NZ_CP045929.1\|WP_154075507.1\|955096_955795_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|369777
NZ_CP045929.1\|WP_154075510.1\|960679_961423_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP045929.1\|WP_154075509.1\|958896_960138_+\|PucR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379258
NZ_CP045929.1\|WP_154075505.1\|950839_952543_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378735
NZ_CP045929.1\|WP_154078611.1\|953685_954906_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340831

Protein	Function_ID	Function_description	E-value
NZ_CP045929.1\|WP_154078612.1\|955930_956962_-\|DUF3068-domain-containing-protein	gnl\|CDD\|371444	pfam11271, DUF3068, Protein of unknown function (DUF3068). Some members in this family of proteins with unknown function are annotated as membrane proteins however this cannot be confirmed.	3.70096e-62
NZ_CP045929.1\|WP_154078615.1\|963634_965353_+\|BCCT-family-transporter	gnl\|CDD\|376718	pfam02028, BCCT, BCCT, betaine/carnitine/choline family transporter.	0
NZ_CP045929.1\|WP_154078617.1\|967965_968775_+\|DUF3152-domain-containing-protein	gnl\|CDD\|371483	pfam11350, DUF3152, Protein of unknown function (DUF3152). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	2.37766e-94
NZ_CP045929.1\|WP_154078616.1\|966705_967659_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|184875	PRK14875, PRK14875, acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional.	5.69813e-25
NZ_CP045929.1\|WP_154078614.1\|960335_960626_-\|DUF4873-domain-containing-protein	gnl\|CDD\|374407	pfam16170, DUF4873, Domain of unknown function (DUF4873). This family consists mostly of short uncharacterized proteins found in various high GC Gram positive bacteria, primarily Mycobacterium species. However in some proteins, such as for instance Rv0943c proteins from Mycobacterium tuberculosis H37Rv, DUF4873 domain is found at the C-terminus, following the flavin-binding monooxygenase-like domain pfam00743, which is why probably many proteins with DUF4873 domains are annotated as monooxygenases. However these functions are not confirmed experimentally and the function of DUF4873 domain is still unknown.	1.78915e-34
NZ_CP045929.1\|WP_154075513.1\|965852_966488_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.52621e-16
NZ_CP045929.1\|WP_154075503.1\|945145_949258_+\|DUF3367-domain-containing-protein	gnl\|CDD\|378735	pfam11847, DUF3367, Domain of unknown function (DUF3367). This domain is functionally uncharacterized. This domain is found in bacteria and archaea. This presumed domain is typically between 667 to 694 amino acids in length.	0
NZ_CP045929.1\|WP_154075514.1\|968971_970150_+\|adenylyltransferase/sulfurtransferase-MoeZ	gnl\|CDD\|181156	PRK07878, PRK07878, molybdopterin biosynthesis-like protein MoeZ; Validated.	0
NZ_CP045929.1\|WP_154075511.1\|961495_962395_+\|diiron-oxygenase	gnl\|CDD\|378680	pfam11583, AurF, P-aminobenzoate N-oxygenase AurF. This family is a metalloenzyme which is involved in the biosynthesis of antibiotic aureothin by catalyzing the formation of p-nitrobenzoic acid from p-aminobenzoic acid. AurF is a non-heme di-iron monooxygenase which creates nitroarenes via the sequential oxidation of aminoarenes.	5.30965e-113
NZ_CP045929.1\|WP_154075504.1\|949482_950712_-\|polysaccharide-biosynthesis-protein	gnl\|CDD\|240533	cd13128, MATE_Wzx_like, Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	1.24151e-08
NZ_CP045929.1\|WP_154075509.1\|958896_960138_+\|PucR-family-transcriptional-regulator	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	9.43449e-19
NZ_CP045929.1\|WP_154075512.1\|962519_963464_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.12519e-24
NZ_CP045929.1\|WP_154078613.1\|958482_958710_-\|DUF3107-family-protein	gnl\|CDD\|378634	pfam11305, DUF3107, Protein of unknown function (DUF3107). Some members in this family of proteins are annotated as ATP-binding proteins however this cannot be confirmed. Currently no function is known.	1.34088e-33
NZ_CP045929.1\|WP_154075515.1\|970327_971128_+\|TIGR02569-family-protein	gnl\|CDD\|131620	TIGR02569, conserved_hypothetical_protein, TIGR02569 family protein. This protein family is found, so far, only in Actinobacteria, including as least five species of Mycobacterium, three of Corynebacterium, and Nocardia farcinica, always in a single copy per genome. The function is unknown. [Hypothetical proteins, Conserved].	5.78183e-78
NZ_CP045929.1\|WP_154075507.1\|955096_955795_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	1.03013e-19
NZ_CP045929.1\|WP_154075510.1\|960679_961423_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.38645e-14
NZ_CP045929.1\|WP_154075505.1\|950839_952543_+\|hypothetical-protein	gnl\|CDD\|378735	pfam11847, DUF3367, Domain of unknown function (DUF3367). This domain is functionally uncharacterized. This domain is found in bacteria and archaea. This presumed domain is typically between 667 to 694 amino acids in length.	0.000196868
NZ_CP045929.1\|WP_154078611.1\|953685_954906_-\|glycosyltransferase	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	1.37653e-57

>NZ_CP045929.1|WP_154075509.1|958896_960138_+|PucR-family-transcriptional-regulator
MVSPSTHSIAPAHRAIGRTMLNKVPELADRFARLLSEQDDFYREVYRVAPDELRKVCEANFTRALRAFIDGEEPALDAARKTGRAQALKGIPLSAVLRAFRLAGSFVYQDLLEQADLSSMPADQILQISSQVWQTIDVYSASLASAYNEVATESEQHDEWTRRSAWLELLAGHRLEPSAVHNAAQVLGLPMTGRFVVVAGAAAADDRAPEADGTDTNVTVSEAGEAAPVQVSRLLRSTGYQSAWRTGPGSEIGIVVVERDLRTLREALESTPVAVGVSTPFGSLRDVPAAVERARLAQQCVPPGVSGVAVYGDTPVTTLVAGAPTLAREVALAPLAGVLELPEAERTPLLDTLRVWYETAGSAKVAAGELFVHPNTVRYRMRRVQELTSLDVSNPVAVAELYVALEAHRFAPS
>NZ_CP045929.1|WP_154078613.1|958482_958710_-|DUF3107-family-protein
MEVKIGVVDSSRELTVASNQSPDEVESLVADALKTADGVLALTDDKGRRFIVPSARLAYVEIGAVESQRVGFGVG
>NZ_CP045929.1|WP_154075508.1|957253_958018_+|hypothetical-protein
MRNIGERAVGTPARPARDTGLERVTISDCAGANGRAFEWGGPGVALTRGLAEPIRAGVRAATHAVDADTRTDAVRLVELGVCASAVVQEDSRGLAAPPDRGRVQWHARGLTVIARDLADLVATVPLVGQVERAGTHTEPIRVGAHSDSIADTRMRDRIGDVAARLSLGGVPVVDLDAERSPLFGGLLRRVNRASRADIDVVVTSVPPPDTHPAAGTVVSFPSTPDGAGDHVQVRAREGVAGTSVLDLLRSLATP
>NZ_CP045929.1|WP_154078612.1|955930_956962_-|DUF3068-domain-containing-protein
MFAIAMAVLLPTHVYHSLAKTPLNQNSTTVLDGTAERVLAVEETPEGPEPTIREDVDLTAVAKVQANFSRPEMTEGSDVAVWAQTLRVTDNADDKVVSASKRQVCFDRRTAEGYTGTDENRCAPESTFVAKLQQDPDAPGQKPQEYAEYGGQPGLHFKYPFDTQRKSYEIYDNTIGKPVTSSFEGTDEVNGLPVLKFVQPIPATQFSEQQVAGELVGAGPEPSVDVGRYYTNTITDYVEPTTGLIVKQEQQQRQELRLPGQDEGTVVLDGDLEYSPDTIAAKVAQAEESMGGLKMLSAAPWVLGPVGALLVVAGLLLLPRRNRTTPDREFDAPTHPQHAMSDR
>NZ_CP045929.1|WP_154075507.1|955096_955795_+|methyltransferase-domain-containing-protein
MRLFTAFLHEQTDPDRFYGELAKDSVEQLARYTPLSGRTVVDVGGGPGYFCDAFRAAGAGYLGVDPDVGELSARGTPGQNMVRASGTELPVRDGAVDVCYSSNVLEHVSAPRTMLEEMCRVTRPGGIVFVSYTPWLSPWGGHETAPWHFAGGDFARDRYIRKNGHEPKNRFGETLFPISISAVLDWARGTPSAELLHAFPRYHPWWATWIVRIPGIREVASWNLAMVLRKKP
>NZ_CP045929.1|WP_154078611.1|953685_954906_-|glycosyltransferase
MLLLNWRDTGHPAGGGSERYVEQMAHGLARRGYRVDIQCAAYPHAGVGEWRDGVRYRRRGSTFSVYAHALLASARTRADVVIDVQNGMPFLSKLVARCPVVVLVHHVHREQWASALGSVFGRVGWWIESWLAPKVYRKCRYVTVSEVTRSELAELGVDPARVEVVPNGLDPVPAHSGRRAPEPTLAVVSRLVPHKRVEHAIDVLALLGQRWPTLRLDVVGQGPWENELREYARTRGVERRVTFHGWVEEHTKHEILARSWLHLCPSVKEGWGIVIMEAAAHGVPSLAYRSAGGVTESIVEDRTGLLADDFDEFADGVERLLADAHLRRVMGEAATTHAGRYRWEDSVAAFESLVRELTVDGPDQRVEPVDEPVGERGGRPLVEVPATRPHGERGGAVDGDRAEGHA
>NZ_CP045929.1|WP_154075506.1|952547_952724_+|hypothetical-protein
MGNVIGAAVALVLGLGLAAGAGQGMIALADPDGSDEVTNAVNSSVNPMSDPDTLYGSR
>NZ_CP045929.1|WP_154075505.1|950839_952543_+|hypothetical-protein
MDADDSTTPPHGRRVLLAVSAALTVLVLGPLLGPGFALSYDMVFAPRQYLLPESFGLGEVLPRSVPADAVVAAATSVLPGDLVQTLVLAAAVFSAAYGAGRLVPTASVPTRVVAAVAYVWSAYFAERLFLGHWPLLLTYACLPWIALAALRLRRGQARAGARLVLATAPAVLTAPGGVLAAGVALACAGRRKVGIVLGVSAVLNAPWWVPSLLRGAETLSDPAGVAAFSARAESWGPAWLSVLGLGGVWNAEVVPDSRTGPLAPIFVLVTVAVALVGLRRLACRWGRPAWALCVLGAIGFALAVLATMPMGEPLLAWAMQHVPGAGLLRDGQRWVAWWALPWALGFALGAELLAEYVRSRGRTAVLLGAALLPVVVMPDLAWAGWGRMEPVDYPADWYRVREILADDPAPGAVVTLPLSSFRSFAWNEHRTQLDPAPRVLPRSTVIDDRLRVGDAVVAGEDPRARHVRSASSAENLTEAGIGWILVEHGTPGRADPALLEDAAEVWSGPWLSLYRVPGDVTPTEIPRTQVVAVAAANGLAGGLMIGTLLWLGLPSGRLSRITRRTKE
>NZ_CP045929.1|WP_154075504.1|949482_950712_-|polysaccharide-biosynthesis-protein
MTTREAAPPRYRWLARLEPLLVAAALAGSNAASYVLNVVAARVLAPAHFGELSALLAVLVIGVVPAMGLQTVVALRVAGGDDPAPRREFTARLLASGLVTTTAVLGIGALVVLPLTLLLHLDGPLPAMFLVVALAPLTMLGLFHGILQGSKRFVALAGLVALEGVGKVGGALLGLLTFGTSAATMAGAALGSLVVAAVGWWQCGAPLPHAFRGERLGEIVHAIQAMFALVLLLNLDLVLARFVLPGPDAGEYAVGSIVTKIAYWLPQAVAVVVLPRLAHRAARKRTVPAALVVCAGLGASVIGFCAFSGSELVSIIGGGEYASSTLSLWPFALVGALLSMVQVLLFSRLADADRRVTVLMWSAVALEVVLVLIWLHDGPLEVITAAALTAGALTVGSAALDLHRARRPN
>NZ_CP045929.1|WP_154075503.1|945145_949258_+|DUF3367-domain-containing-protein
MVTTGGGEHDRLPQRGGVDSTRTWPRRPTPALWVGAVLVLVSFLQAPGKITSETKLDLAMDPAGFLGRALHMWNPQATSGELQNQAYGYLFPMGPYFVALDAIGVPTWIAQRLWCAILLCLAFGGALLLARSLRIGTEPSRLVGAVAYALAPRMITEIGVVSAEMMPAAMLPWVMLPLVRAERIGSPRRAAGLSALAVLGMGGVNGAMVVMALVLPGLWLLTRRWTRGHVKLVAWWCVFVPVVSLWWILPLLLLGRYSLPFLDYIESAATTTGPLSLFQVLRGTDQWVAYIVQDGPWWPAGWAMINNPVLIVATGVVAALALWGLADSRLPERRFLVLAAITGLTFLAVGFVGELGSPFAETARELLDGPLAPLRNVHKFDPVLRLALALAFMHAVTVLGIERAPRTRWSGALWTAGAAALVVVAAAPAFLFMLRLEPGWDETPRHWQEAMSWVAERDEHARTLLVPSTGFGLYDWGRTIDEPAQPLASSPWAVRNQIPLGSEGNTRMMDAVDEVLAHGRGDPHLADMLARSGFRFLLLRNDIPREKTEAPPLSRMHEGLAASPGLRKVADFGPTVQPGTGESASVVDTTAPPVASVQIYEVESEVPRATATPLDEVTTVSGGPESLLPLMRSGQLDPRTPVVLTGDGGAGGERVVTDGLRDRERDMGRVRENLSATRTSEQPTRFDRGAQDLLPVRGEQHRTFAELRGITSVSASTAASYADSAGRVDPTHQPFAAVDGDPTTAWHSSSFSGPDGQWLEVDLPGPRDVDSVDLSFVEDLRVGWPASRIRITTDQGSIEHSVQRGGGTHSYPTRAGPTSKVRVTVLSLVVGRQDGNVGISELAVPGVEAERLLRVPSDTGALAAGPRPGFTFSRGPAPEFACQRDASGATRCDAGLAQEGEEPRGPQRLFSTDTDGTYQVGGTVLPAPGGVVPFAPQGLDVTASSQLGGDPAAGPFAAIDGDAATAWVPDVTDLDRSLRLSWDGPREISGMRLFVDNAHTAIRPNSVEIVTPEATYRSDVDAAGRVEFPPVTTDVMEIRITGFDGQDPVTGQPTNRHAGIGTLELTGAEDLLTPADPETPFTVPCGQGPPVTIDGVEHPTSVRGTIADVTGHRTLPLIPCDDLAEDVPIPAGEHEIRTAPSDAFVVQGLWLRPAEDGPRAEPAPSRPVEVTDWNETSRSLDLAPGPRSVLSVPENANQGWVARLDGERLEPTRVDGWQQAWVVPEGAGGEVTLDFEPNSRYRGGLLAGGFAALAVVGATFLPVRRRQQVSTAPSGGRMTFAAVAGLLAVLGGIPGVVALAAGLGLRWWRPSLSPWFALGGMAVATTIAFAGQVLGFGQEWANAGPSQAAALLAVGAVIGTCLDFSRRGSG
>NZ_CP045929.1|WP_154078614.1|960335_960626_-|DUF4873-domain-containing-protein
MLRTEDAAIAVEVVLRGHFQPIDGRFHWYGRIAANPEVDALTGGRSARVVLSTDDGDALGTLSDPDPWSRHRITGVGRPPFAVPTSLSDLEPTDPA
>NZ_CP045929.1|WP_154075510.1|960679_961423_-|TetR-family-transcriptional-regulator
MSDPHRSVKSTRSGGDARRERWRHHRAARRAEFVEATVRAIGEHGPEVGMDEIAAEAGVSKPVLYRHFHDKSDLFAGVGSWGTQLLMQRLAPTINEGGSPRERIHRIIDTYLTLIEEYPDLYRFVVHRAYADRPAHDDPVGMEKAEIAKTLSRMLGEFMRVLELDSGGVEAWSHGLVGMVQASGEWWLERRSMSREDLARYLTQIIWHAIDGVLRNGGIVLDPDEPLAPELHVVPDIADGESGESGS
>NZ_CP045929.1|WP_154075511.1|961495_962395_+|diiron-oxygenase
MSSAASLNDREKTAARLLKSTAKNSYDPEVDIDWDAPLSDDSPYIPFHRSSLYGTHLWDRLSDEQRVELTKHEFASIASNGLWFEILLMQLLLKEVYDRDPRSNHVQYALAEIADECRHSTMFARAVERVGAPAYGPLPWVHRFAKILPWLVHGPSLYASVLVAEEVLDRFQRDQMNDEQVQPLVRMVNRIHVLEEARHVTFAREEVLRGMAEAGPLARRYHQYVTALVGYFILFSLINPHVYKAVGISPREGHAAAWSNPHFRETRRWAGEKIMSFLDGAGLVGRPGARWWKKAHLLR
>NZ_CP045929.1|WP_154075512.1|962519_963464_+|alpha/beta-fold-hydrolase
MAVRTLDRSSVFTTSDGVRLHVSDTGPDAAPVTVVFLHGWTLDLATWDTVCGQLDEGLRLLRFDLRGHGRSQPAPPETATIERCALDLAELIDERVPTGPIVLAGHSMGAMTIMALAEGRADLFAERIAGVALVATSGGGLGLSRATFGLPGPLGKASTSVQRGLQRWLAGNEHSRLLRDSRTMRPGVRWLLFGKRARRADVAATAESLACCHPRSMGQFRESLATHERLERIEALRSVPTVVLAGLSDRLTPYPHARRLARALPEAELLVHADAGHMLPLERGDAVAARISDLVRRVWPDESARAGTDLNDPT
>NZ_CP045929.1|WP_154078615.1|963634_965353_+|BCCT-family-transporter
MVDRPGRTDWGVFGIAAVLATAFIAWGLLATESLQAFSETALQVLVRNGGWVFVTAGTGFVVFGLILAFTRFGRIRLGDDDEKPEFRTSSWIAMMFAAGMGIGLMFYGVAEPLQHFTTPPPGTNVAPGSQEALGAAMATSLFHWTLHPWAIYATVGLALAYSSYRRGRKQLLSSAFVPLFGERTANGTVGKIIDILAVFATVFGTAASLGIGATQIAAGLQQVGWVGSMSNTLLVAIITVLIAAFVISAVSGVSKGIQWLSNSNMVLAIVLAAFLFVVGPTVFILDLIPNAVGSYVSDFGMMISRTGSVGGEDTTEWLSTWTIFYWAWWISWAPFVGMFIARISRGRTVRQFVGGVLMVPSAISLVWFAILGGTALFEQRNGVGLADASGEEEQLFGMFDQLPFSGVLSVLAMLLIINFFVTSADSASVVVGSLSQQGSARPRMWVVVFWGVVIGGVAISMLLAGGDEALTGLNNTTIIAASPFVIVVILLCFSLMKDLRQDRVMLVESRSAEVLEEAVIYGTEEHDGNFHLEVTPSEPSDDSDDSGDSGDSGDSGDSGKEESRSSSSSDES
>NZ_CP045929.1|WP_154075513.1|965852_966488_-|TetR-family-transcriptional-regulator
MTEAAAQGVDQSARGVRLPRTARRAQLLDAAQHVFVTNGYHAAAMDDIAERAGVSKPVLYQHFPGKLELYMALVDKHGDALVQRVREAISSTPDNKQRVKQAVQALYEFVDGEGQAFRLLFESDLRGEPAVEKAVDDAMSSCIDAVTDVVAADAGIDHERARLLAVGLVGLSQVTARYWLGTEGSVSRDEAVSLMSTLAWKGLAGFPLQQG
>NZ_CP045929.1|WP_154078616.1|966705_967659_+|alpha/beta-fold-hydrolase
MRWEDVPSAVEAVAPAPLRTVELDTTVGPVHLGIRDTAGDSGADAVAVHLHGLAASSTHWTDLTRMLTSRTRSIAVDLPGFGWSEPPNGFDYRRRSHADVVIALLESLGVGAVHLFGNSFGGAVAIEVAARRPDLVRSLTLVSPAVPDLRPDPRRVSDRRMLFTSVPVLGRRMRRQLAAASARERADKLIRLCVSDSSLLSPDRVGDVVRELEDRAALPWAATALATTTRELVRSWMVRPSESLWSLLHQVQAPALVVWGTDDRLVSVRKAPRTARQLRRGRLLVLPRTGHVAQMERPRLLAAAALGMVDEVAAGRW
>NZ_CP045929.1|WP_154078617.1|967965_968775_+|DUF3152-domain-containing-protein
MLVVATALAVFQVVEPASESPGGAGAGGDQAADVPEAPVLDEAPPGQRYSPEMFSADLPPGAPIPESGAGTFDVLPGNSPQVGQGDMYRYTIEVETGIELTEGRDAFGNLVEQTLSDPRSWTHPEAGGIALQRVDDQGPPPDFRVTLVSQNTARQVCGYGQGLPFDTSCRIDDRVYINAARWVRGAISFEGDSGTYRRYAINHEVGHVFGNPHVPCGQDGALAPVMMQQTFSVANDELHELNKAVPQGADIPRDGKVCKYSAWPFPVAG
>NZ_CP045929.1|WP_154075514.1|968971_970150_+|adenylyltransferase/sulfurtransferase-MoeZ
MSGDTAITLPPLVEPAAELTKEEVARYSRHLIIPDVGMDGQKRLKNAKVLVVGAGGLGSPALLYLAAAGVGTLGIVEFDEVDESNLHRQIIHGQSDLGRSKGESARDSIAEVNPYVRVNLHETHLTSENALDVFRDYDLILDGTDNFATRYLVNDAAVLQGKPYVWGSIFRFEGQASVFWDEHGPNYRDLYPEPPPPGMVPSCAEGGVLGVLCASIGSIMVNEAIKLITGIGETLLGRLMIYDALEMSYKTVKIRKDPDADPITELIDYEAFCGVVSDDAQQAAVNSTITPQELKDKFDRDEKFELVDVREPHEYEIVKIDGSTLIPKDRILSGEALAELPQDRQIVLHCKSGGRSAEALAALHKAGFSDAVHVGGGVLGWANQVDTSLPTY
>NZ_CP045929.1|WP_154075515.1|970327_971128_+|TIGR02569-family-protein
MSATPEPPPTHVRAAFGARGEEEPELLEGGIAWRCGEVVLRPASHTAEAAWVAQTLDLLEPEDVRLARPLRSTDGRWVVSGWSANRNIDGKPEPRHDEVVAASLRLHAASSFLAKPRFLDSRQDLYSLADRMAWGEQEHPLVPEKGGRLYDVLEGSRRKVQLRQQVVHGDLFGNVLFAGNAPPGILEFAPYWRPAEWAAAVAVIDSLAWGGADPAIVERWSHLAEWPQSLLRALLFRLAVHALHPASTTQSLGGLEYASQMVLEVL

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Crispr_ID: NZ_CP045929_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045929_4

1134275-1134386

Orphan

Consensus_repeat	Method
CGGGGTGAGCGGCACGTTCGCCTCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP045929_4

>merge|NZ_CP045929|4|1134275-1134386|CRISPRCasFinder
TGGTGCGAACGGCACTTTCGCCTCGTCTCGCGGGGTGAGCGGCACGTTCGCCTCACTTGGGGTGAGCCGTCGTCGTGCGTGTGGGACGGGGTGAGCGGCACGTTCGCCTCAC

>NZ_CP045929|4|4|1134275-1134386|CRISPRCasFinder
TGGTGCGAACGGCACTTTCGCCTCGT	CTCGCGGGGTGAGCGGCACGTTCGCCTCACTTGGGGTGAGCCGTCGTCGTGCGTGTGGGA
CGGGGTGAGCGGCACGTTCGCCTCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045929.1\|WP_154075649.1\|1138967_1139228_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045929.1\|WP_154075640.1\|1127669_1128620_+\|cysteine-synthase	unknown	unknown	gnl\|CDD\|273463
NZ_CP045929.1\|WP_154078636.1\|1140419_1141928_-\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|225962
NZ_CP045929.1\|WP_154075638.1\|1126809_1127265_+\|peptidase	unknown	unknown	gnl\|CDD\|163701
NZ_CP045929.1\|WP_154078634.1\|1129707_1130331_+\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|366759
NZ_CP045929.1\|WP_154075646.1\|1135538_1136012_-\|thioredoxin-dependent-thiol-peroxidase	unknown	unknown	gnl\|CDD\|224146
NZ_CP045929.1\|WP_154078633.1\|1128716_1129577_-\|SMP-30/gluconolactonase/LRE-family-protein	unknown	unknown	gnl\|CDD\|369882
NZ_CP045929.1\|WP_154075645.1\|1134516_1135287_+\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|376667
NZ_CP045929.1\|WP_154075650.1\|1139310_1140159_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262
NZ_CP045929.1\|WP_154075643.1\|1132809_1133565_+\|ribonuclease-PH	unknown	unknown	gnl\|CDD\|178914
NZ_CP045929.1\|WP_154078635.1\|1132178_1132601_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373064
NZ_CP045929.1\|WP_154075653.1\|1142862_1143657_+\|trypsin-like-serine-protease	unknown	unknown	gnl\|CDD\|238113
NZ_CP045929.1\|WP_154075648.1\|1138013_1138811_-\|IS5-family-transposase	unknown	unknown	gnl\|CDD\|379129
NZ_CP045929.1\|WP_154075652.1\|1142005_1142557_-\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|225937
NZ_CP045929.1\|WP_154075639.1\|1127360_1127639_+\|molybdopterin-synthase-sulfur-carrier-subunit	unknown	unknown	gnl\|CDD\|340594
NZ_CP045929.1\|WP_154075644.1\|1133561_1134176_+\|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	unknown	unknown	gnl\|CDD\|234648
NZ_CP045929.1\|WP_154075647.1\|1136152_1137883_+\|pyruvate-dehydrogenase	unknown	unknown	gnl\|CDD\|180614
NZ_CP045929.1\|WP_154075651.1\|1140159_1140351_+\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
NZ_CP045929.1\|WP_154075641.1\|1130327_1131143_+\|glutamate-racemase	unknown	unknown	gnl\|CDD\|234851
NZ_CP045929.1\|WP_154075642.1\|1131139_1131901_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293802

Protein	Function_ID	Function_description	E-value
NZ_CP045929.1\|WP_154075640.1\|1127669_1128620_+\|cysteine-synthase	gnl\|CDD\|273463	TIGR01136, Cysteine_synthase, cysteine synthase. This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family].	1.63304e-130
NZ_CP045929.1\|WP_154078636.1\|1140419_1141928_-\|PH-domain-containing-protein	gnl\|CDD\|225962	COG3428, COG3428, Predicted membrane protein [Function unknown].	2.53995e-48
NZ_CP045929.1\|WP_154075638.1\|1126809_1127265_+\|peptidase	gnl\|CDD\|163701	cd08070, MPN_like, Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding). This family contains archaeal and bacterial MPN (also known as Mov34, PAD-1, JAMM, JAB, MPN+)-like domains. These domains contain the signature JAB1/MPN/Mov34 metalloenzyme (JAMM) motif, EXnHS/THX7SXXD, which is involved in zinc ion coordination and provides the active site for isopeptidase activity for the release of ubiquitin from ubiquitinated proteins (thus having deubiquitinating (DUB) activity) that are tagged for degradation. The JAMM proteins likely hydrolyze ubiquitin conjugates in a manner similar to thermolysin, in which the zinc-polarized aqua ligand serves as the nucleophile, compared with the classical DUBs that do so with a cysteine residue in the active site.	2.81112e-38
NZ_CP045929.1\|WP_154078634.1\|1129707_1130331_+\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|366759	pfam01694, Rhomboid, Rhomboid family. This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.	2.17144e-17
NZ_CP045929.1\|WP_154075646.1\|1135538_1136012_-\|thioredoxin-dependent-thiol-peroxidase	gnl\|CDD\|224146	COG1225, Bcp, Peroxiredoxin [Posttranslational modification, protein turnover, chaperones].	6.95235e-74
NZ_CP045929.1\|WP_154078633.1\|1128716_1129577_-\|SMP-30/gluconolactonase/LRE-family-protein	gnl\|CDD\|369882	pfam08450, SGL, SMP-30/Gluconolaconase/LRE-like region. This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyze diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.	2.61549e-53
NZ_CP045929.1\|WP_154075645.1\|1134516_1135287_+\|TSUP-family-transporter	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	4.52593e-21
NZ_CP045929.1\|WP_154075650.1\|1139310_1140159_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	4.57966e-10
NZ_CP045929.1\|WP_154075643.1\|1132809_1133565_+\|ribonuclease-PH	gnl\|CDD\|178914	PRK00173, rph, ribonuclease PH; Reviewed.	1.91617e-156
NZ_CP045929.1\|WP_154078635.1\|1132178_1132601_+\|hypothetical-protein	gnl\|CDD\|373064	pfam14430, Imm1, Immunity protein Imm1. A predicted immunity protein, with an alpha+beta fold and a conserved C-terminal tryptophan residue. The protein is present in a wide range of bacteria in polymorphic toxin systems as an immediate gene neighbor of the toxin gene.	8.03026e-14
NZ_CP045929.1\|WP_154075653.1\|1142862_1143657_+\|trypsin-like-serine-protease	gnl\|CDD\|238113	cd00190, Tryp_SPc, Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.	8.14704e-79
NZ_CP045929.1\|WP_154075648.1\|1138013_1138811_-\|IS5-family-transposase	gnl\|CDD\|379129	pfam13340, DUF4096, Putative transposase of IS4/5 family (DUF4096).	1.51417e-24
NZ_CP045929.1\|WP_154075652.1\|1142005_1142557_-\|PH-domain-containing-protein	gnl\|CDD\|225937	COG3402, COG3402, Uncharacterized conserved protein [Function unknown].	2.33531e-28
NZ_CP045929.1\|WP_154075639.1\|1127360_1127639_+\|molybdopterin-synthase-sulfur-carrier-subunit	gnl\|CDD\|340594	cd17074, Ubl_CysO_like, ubiquitin-like (Ubl) domain found in Mycobacterium tuberculosis CysO and similar proteins. CysO, also termed 9.5 kDa culture filtrate antigen cfp10A, together with CysM (Cysteine synthase M), forms a protein complex CysM-CysO that represents a new cysteine biosynthetic pathway in Mycobacterium tuberculosis. The replacement of the acetyl group of O-acetylserine by CysO thiocarboxylate to generate a protein-bound cysteine is catalyzed by CysM in a pyridoxal 5?-phosphate (PLP)-dependent manner. The family also includes QbsE that functions as the sulfide donor for the biosynthesis of thioquinolobactin in Pseudomonas fluorescens. A JAMM motif protein QbsD catalyzes removal of the carboxy-terminal dipeptide from QbsE. Both CysO and QbsE are similar to prokaryotic sulfur carrier proteins such as ThiS and MoaD, containing the beta-grasp ubiquitin-like fold.	3.52684e-41
NZ_CP045929.1\|WP_154075644.1\|1133561_1134176_+\|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	gnl\|CDD\|234648	PRK00120, PRK00120, dITP/XTP pyrophosphatase; Reviewed.	4.3218e-103
NZ_CP045929.1\|WP_154075647.1\|1136152_1137883_+\|pyruvate-dehydrogenase	gnl\|CDD\|180614	PRK06546, PRK06546, pyruvate dehydrogenase; Provisional.	0
NZ_CP045929.1\|WP_154075651.1\|1140159_1140351_+\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	5.14689e-16
NZ_CP045929.1\|WP_154075641.1\|1130327_1131143_+\|glutamate-racemase	gnl\|CDD\|234851	PRK00865, PRK00865, glutamate racemase; Provisional.	3.22143e-130
NZ_CP045929.1\|WP_154075642.1\|1131139_1131901_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293802	cd07716, RNaseZ_short-form-like_MBL-fold, uncharacterized bacterial subgroup of Ribonuclease Z, short form; MBL-fold metallo-hydrolase domain. The tRNA maturase RNase Z (also known as tRNase Z or 3' tRNase) catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors. Two forms of RNase Z exist in eukaryotes, one long (ELAC2) and one short form (ELAC1), the former may have resulted from a duplication of the shorter enzyme. Only the short form exists in bacteria. Members of this bacterial subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	8.87257e-88

>NZ_CP045929.1|WP_154075644.1|1133561_1134176_+|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase
MTRLLLASRNAKKLDELRRILAAEGVTGVEVVGLDAVPDYPEAPETGATFEENAMAKAVDAVRATGLPAVADDSGLSVDALNGMPGVLSARWSGGHGDDRANLDLLLGQLADVPDERRGAAFVSAAALATPDGQQVVVRGEWRGVLVRERRGENGFGYDPVFVPEGETRTSAELTPAEKDADSHRGRALRLLLPHLRTLPAPTA
>NZ_CP045929.1|WP_154075643.1|1132809_1133565_+|ribonuclease-PH
MARTDGRGDDALREIRLTRGYQDWPAGSVLVEFGRTRVLCAASVQQSVPRWRAGSGLGWVTAEYAMLPSATNTRGSRESVKGRIGGRTHEISRLIGRSLRACIDLAALGENTITLDCDVIQADGGTRTAAITGAYVALADAITYLGAAKRLSDPKPLSCSIAAVSVGVVDGRVRLDLPYEEDSRAEVDMNVVATDHGTLVEVQGTGEGATFPRSTMDTMLDFAQEGCAQLTRMQADALAEPYPGELPGSKS
>NZ_CP045929.1|WP_154078635.1|1132178_1132601_+|hypothetical-protein
MTITAVWAISSPANTHAGDGLTVTEPSGVDELVDRLAEPNTGLAALWHEQREAADPDTGMLDHDVVTAVAAGFGYLAYIDTDHDYAVLDGDPDSPPLHVDDVHFPAGSGVVVDVLAEALREFLSTARRPVAVEWREVDPG
>NZ_CP045929.1|WP_154075642.1|1131139_1131901_+|MBL-fold-metallo-hydrolase
MRLTVLGCSGGVPGPESPASGYLLEHDGTRLMLDMGNGTLGRLQRVASPFDLDAVVLSHLHPDHCADFAALTVLRRFHPRLPDLGRLPLFGPPEASERLAALYAANPAELAETDLSGFYDFRPPPEEPVRIGPFEITAIPVNHVVPTWGYRVEAGGRVLAYTGDTGPCASLTDLARDVDVLLCEASWADAPDQPSNLHLSGRQAGELATRAGVRRLLLTHLLAWSDRAPVDAEARAAFTGDAEWVVPDAQYTV
>NZ_CP045929.1|WP_154075641.1|1130327_1131143_+|glutamate-racemase
MSKAPIGVLDSGVGGLTVARALVDQLPAERLRYVGDTAHSPYGPKPIAEVRSRTLTLLDELVDSGVKMLVIACNTASAACLRDARERYDVPVVEVVLPAVRRAMAVTRNDRVGVIGTTGTIRSRAYEDAFTAAPQVRLTTAACPRFADFVERGITSGRQVLGLAQSYLDPLQQADVDTMVLGCTHYPMLTGVLQLAMGEQVTLVSSAEETAKDVVRVLTEHDLLAPPGVPATHEFRCTGEPDRFAKLAARFLGPTPVGGAVEQWSMSGSRA
>NZ_CP045929.1|WP_154078634.1|1129707_1130331_+|rhomboid-family-intramembrane-serine-protease
MSPSSENRSRVIPAKPVRSALLVVLFVVGLYVIEFYDAFFLGQALNREGIFPRQVDGLDGILWAPLLHGDFAHLGANTVPLLVLGWLVMAGGLGQFVGVTATIWLLGGLGTWLIGFPAPHIGASGLVFGWMVFLLMRGFFARSVGQIVVAIVLFLYWGGILWGVLPGQPGVSWEGHLFGALAGALAAYMIGRQVRDADPWRPGRLSG
>NZ_CP045929.1|WP_154078633.1|1128716_1129577_-|SMP-30/gluconolactonase/LRE-family-protein
MSGRVEVAVAAGAREGGAPTWDVGWDTLLWVDRAADESAAGTVHRHVPGGANHSMELAQRVGAAKPRGRGGLVLHLDEGVAVFEADGQRRTWLTYWARDGVRSGATAVDRAGRLWATTVREDESGGGWLARVLPDGSASAVLTDLPAANGLAFDAEANRLYLADSATGLVEILDVEHESGAVGPRHTFVQVEDGEPAGLCVDGSGAVWLALRDAGQVRRYTPEGELDTTVDLPLRRPLGCCFGGPELADLYVTSAPEGLAEPGEDDGAVLVLRGVGPGVRPYAFAG
>NZ_CP045929.1|WP_154075640.1|1127669_1128620_+|cysteine-synthase
MARYDSLLDALGDTPMVGLPSLSPSPDVRLWAKLEDRNPTGSVKDRPALAMIEAAEKEGRLTHGCTILEPTSGNTGISLAMAAKLKGYGLVCVMPENTSEERRQILQAYGARIVSSPAAGGSNQAVAVAKELAEQNPDWVMLYQYGNSANADAHRRGTGPEILRDLPSVTHFVAGLGTTGTLVGVGRYLREQKSDVQVIAAEPRYGELVYGLRNLDEGFVPELYDAEVLSRRFSVGSYDALRRTRQLLESEGVFAGVSTGGVLHAALTVGEKAAAAGDAADIVFIVADAGWKYLSTGAYTGTLDEAASRLDGQLWA
>NZ_CP045929.1|WP_154075639.1|1127360_1127639_+|molybdopterin-synthase-sulfur-carrier-subunit
MAVNVSIPTILRTHTGGQKAVEASGGTVAEVINDLDSRHGGIKDRLVKEGSLHRFVNVYINDEDVRFVGGLDASVTDGDSVTILPAVAGGMR
>NZ_CP045929.1|WP_154075638.1|1126809_1127265_+|peptidase
MLVIRRDLVDAMVAHARRDHPDEACGVIAGPDGSDRPERFVEMVNAERSPTFYRFDSTEQLRVWRAMDAADEEPVVIYHSHTATEAYPSRTDISYASEPNAHYVLVSTRDPEEYELRSYRIVDGEVTEEPVEVVESYMFAHTGHDEVPDRG
>NZ_CP045929.1|WP_154075645.1|1134516_1135287_+|TSUP-family-transporter
MFTGPLELGLLVLAGFVSGVFNAVAGGGSLLLFPALLATGMPPLIANVTNSVAQGPGFIGAAVGQRRDLLGQRRRVLLTSSAAVVGSVIGCVLLLALPGSVFDVVVPVLVGLSAILMALQNQIRRWLGNSEVDAPDRTVLLTVGIFLAAVYGGYFAGARSVIFIAILMLAATDPMRRLNALKNWLGLIGSAATLVVLALLAPVDWWAALTLVPSTLIGGYIGGKVAQRLPATALRYTIVVIAAGVAVYLAWDAFVN
>NZ_CP045929.1|WP_154075646.1|1135538_1136012_-|thioredoxin-dependent-thiol-peroxidase
MTEQNRLAVGDTAPEFSLPAADGSTVSLSDYRGRSVVVYFYPAASTPGCTKEACDFRDSLGVLDDAGFDVVGVSPDTPAKIAKFREAEGLTFPLLSDADKSVMSAWGAFGEKKNYGKVVQGVIRSTFVVDPEGKIAQALYNVKATGHVERLRKELGV
>NZ_CP045929.1|WP_154075647.1|1136152_1137883_+|pyruvate-dehydrogenase
MPTIADQFIEVLAQAGVKRIYGIVGDSLNPIVDAVRRTDGIEWVSVRHEESAAFAASSEAQVTGSLAVCAGSCGPGNLHLINGLFDAHRSGAPVLALASHIPSEQIGTDFFQETHPQELFQECSGFCELLSQPEQMPRLLRSAIQSAAGRRGVSVLVLPGDVANKSTVKPTGHGVVDCVPPTVVPPESQVAQLADSLNSAERVMLFCGAGARGAHKEVMDLAGALNAPVGHALRGKEWIQYENPYDVGMSGLLGYGACHEAMHSADRVVLLGTDFPYNDFLPQQNTVQVDIDPTHLGRRSVLDLAVQGDVGETIRAVLPRVRQKSDRSYLDRMLREHAGKLEQVVEAYTSNVEKHVPIHPEYVADAVDDLTADDAVFTVDTGMCNVWAARYITPNGRRRILGSYVHGSMANALPQAIGAQFAEPDRQVVALCGDGGLSMLLGEILTVRARRLPVKMIVFNNSSLGMVKLEMLVDGIPSFGTDHVGVNFAAIADAAGIDSVRVERPADVRENVREMLRRPGPALIDVVTDPDALSMPPRITGEQVAGFALAVSRTVLSGGVGKMVQLARSNLRNIPR
>NZ_CP045929.1|WP_154075648.1|1138013_1138811_-|IS5-family-transposase
MTDAEWAVIEPLLPTAACASPAGGRPEKHHRRDIVDAIRYVTDNGVKWRALPVDFPPCKTVYGFFARWRENGTVEIMRDALREQVRQQAGRRPRPTAAAIDAQSVRAAETVGDSTRGYDAGKKVNGRKRHIAVDTMGLLLVVMVTAANLQDRPAGRPLLSLLHRAHHRVRHIWADGGYTGTLLTWAKTTLGITVEIVKKLAEQTGFVPLHRRWVVERTFAWISQARRNTRDYERLPEHSEAFINWAMITMMSRRLTRPQTRAPTP
>NZ_CP045929.1|WP_154075649.1|1138967_1139228_-|hypothetical-protein
MLERHALIHSFRAGEDTRNGHSGPRGSSGVYWLLALSMLVWAALFGTAILMWWRGGYARGVRRTTPRAQDGPRHSISRRRHRVRAL
>NZ_CP045929.1|WP_154075650.1|1139310_1140159_+|helix-turn-helix-domain-containing-protein
MTVSPTVRRRRLAAELRRLRASAEVTQQQAAAHLGCTQAKIGRFETAKRSPSVGDVAALLEFYEVPCDQHEHLITLARDARKRGWWHPYSDVLPEWYETYVGLESEASTIHTYESEAIPGLMQTEEYAFALTKATLIRAEESEIARRVELRMQRQLRVAGSDPAELWAVVGEVALRRRVGGPGVLRRQLDHVLKLAELPHVTLQVMPLDGGAHPAQAGPFVILRYSDHADPGVVYLETHVGGLYLEREIELLNYKRMMDHLRAHALNPEGSAQLIHRRRGEL
>NZ_CP045929.1|WP_154075651.1|1140159_1140351_+|DUF397-domain-containing-protein
MECITDWRTSTRTQGQGQCVEVGFGPDRIAVRDTKNRTGGHLCVTAARWESFVSGVKLGNFDS
>NZ_CP045929.1|WP_154078636.1|1140419_1141928_-|PH-domain-containing-protein
MLPEGEGWTRLDPKSVVAVSSLVALLAIPPLAIMALSGAERMAVLVTAGGWLLIVLGVCITSWVSWHFTRYRITGHRFELRAGRLSRSHKSIPRDRIRSVDLTANPVHRVFGLSVVKIGTGQQAGDSEIKLDAVTTPRAEALRHELLRTPSTADTAAESHTASVPAAETLSSIRPAWFGYGALTVSLAAVVWGAIASAIGSFADVIMNLGLDDAVLGDVVSLPVWISVTAGVLGALLVGALGAVLLSLEMWWGFTLTREQDSMLRVRRGLLTVRSLSLEERRLRGVELVEPMLLRWVGGARLNAVATGLSDQQSGNRQPDRAALMPPAPREEVRRVSGVALGTDPPVPSRTLVRHPFAALRRRLFRATAVGVLVGTALVLAATVTGWLIPLAWALAIAALLIAWAFGLESYWNLGHELLARHLLARSGVGVRRTVALERDGIIGWRVEQTIFQRPAGLVTISATTAAGSGAYAVRDVAATDGLTVAEEAVPNLLTPFLERDG
>NZ_CP045929.1|WP_154075652.1|1142005_1142557_-|PH-domain-containing-protein
MRRVTRRREATVSSSAIPSSGSRVRLRPPRHRVDRRAILWWTLRAALLVAPLLLALGVAAYFVPSLRTWVLLAFGVVAVLGVAHVVVMPQWRFRVHRWETTDDAVYTSSGWLNQEWRVAPMSRIQTVDSSRGPLQQLLRLSSVTVTTASAAGPITIEGLDRDLAADVVERLTAVTQATKGDAT
>NZ_CP045929.1|WP_154075653.1|1142862_1143657_+|trypsin-like-serine-protease
MALRGLTRFIGISAVALSSFAAVGLAEAAPTQSNDDVNPYIVGGEEANIEDHPFTVALTQSGQQFCGGTIAAPNKIVTAAHCVEGSDPSSIEVVSGRTLMSGSDGTVSQVTDIWVHPEYTDASGSGYDAAVLTLEADVQEAPAELATPDDPAYQPGTTSTVLGWGTTSSGGEQSDHLLKVDVPVVGNPECNEAYGGSINETMTCAGVPEGGKDACQGDSGGPLVVDNKLIGIVSWGQGCAEAGYPGVYGNVGHMHEEIAAQVNA

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Crispr_ID: NZ_CP045929_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045929_5

2510312-2510398

Orphan

Consensus_repeat	Method
GGCGAACGGCACTCTCGCCCCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP045929_5

>merge|NZ_CP045929|5|2510312-2510398|CRISPRCasFinder
GGCGAACGGCACTCTCGCCCCACGAGACGAGGCGAACGTGCCGTTCGCTCGGTGTAGCGGATGGGGCGAACGGCACTCTCGCCCCAC

>NZ_CP045929|5|5|2510312-2510398|CRISPRCasFinder
GGCGAACGGCACTCTCGCCCCAC	GAGACGAGGCGAACGTGCCGTTCGCTCGGTGTAGCGGATGG
GGCGAACGGCACTCTCGCCCCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045929.1\|WP_154076721.1\|2517753_2518014_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045929.1\|WP_154076723.1\|2518612_2519140_+\|2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline-decarboxylase	unknown	unknown	gnl\|CDD\|188295
NZ_CP045929.1\|WP_154078793.1\|2511038_2512385_-\|allantoinase-AllB	unknown	unknown	gnl\|CDD\|238640
NZ_CP045929.1\|WP_154076708.1\|2499952_2501623_-\|PucR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|377939
NZ_CP045929.1\|WP_154078792.1\|2498512_2499523_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|376439
NZ_CP045929.1\|WP_154076719.1\|2515641_2516520_-\|2-hydroxy-3-oxopropionate-reductase	unknown	unknown	gnl\|CDD\|183197
NZ_CP045929.1\|WP_154076720.1\|2516757_2517564_-\|TIM-barrel-protein	unknown	unknown	gnl\|CDD\|163190
NZ_CP045929.1\|WP_154076718.1\|2513671_2515372_-\|glyoxylate-carboligase	unknown	unknown	gnl\|CDD\|183066
NZ_CP045929.1\|WP_154076712.1\|2504394_2506725_+\|xanthine-dehydrogenase-subunit-D	unknown	unknown	gnl\|CDD\|132240
NZ_CP045929.1\|WP_154076707.1\|2497718_2498513_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224045
NZ_CP045929.1\|WP_154076710.1\|2502527_2503007_+\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224991
NZ_CP045929.1\|WP_154076711.1\|2503003_2504398_+\|8-oxoguanine-deaminase	unknown	unknown	gnl\|CDD\|236184
NZ_CP045929.1\|WP_154076717.1\|2512455_2513619_-\|glycerate-kinase	unknown	unknown	gnl\|CDD\|376844
NZ_CP045929.1\|WP_154076709.1\|2501655_2502537_+\|xanthine-dehydrogenase-family-protein-subunit-M	unknown	unknown	gnl\|CDD\|224238
NZ_CP045929.1\|WP_154076722.1\|2518021_2518390_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|379117
NZ_CP045929.1\|WP_154076706.1\|2496720_2497722_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238568
NZ_CP045929.1\|WP_154076714.1\|2507718_2509182_+\|NCS2-family-permease	unknown	unknown	gnl\|CDD\|225161
NZ_CP045929.1\|WP_154076713.1\|2506684_2507260_+\|nucleoside-deaminase	unknown	unknown	gnl\|CDD\|238612
NZ_CP045929.1\|WP_154076724.1\|2519136_2519475_+\|hydroxyisourate-hydrolase	unknown	unknown	gnl\|CDD\|274364
NZ_CP045929.1\|WP_154076716.1\|2510556_2510937_-\|gamma-glutamylcyclotransferase	unknown	unknown	gnl\|CDD\|236177

Protein	Function_ID	Function_description	E-value
NZ_CP045929.1\|WP_154076723.1\|2518612_2519140_+\|2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline-decarboxylase	gnl\|CDD\|188295	TIGR03180, UraD_2, OHCU decarboxylase. Previously thought to only proceed spontaneously, the decarboxylation of 2-oxo-4-hydroxy-4-carboxy--5-ureidoimidazoline (OHCU) has been recently been shown to be catalyzed by this enzyme in Mus musculus. Homologs of this enzyme are found adjacent to and fused with uricase in a number of prokaryotes and are represented by this model. This model is a separate (but related) clade from that represented by TIGR3164. This model places a second homolog in streptomyces species which (are not in the vicinity of other urate catabolism associated genes) below the trusted cutoff.	5.29666e-52
NZ_CP045929.1\|WP_154078793.1\|2511038_2512385_-\|allantoinase-AllB	gnl\|CDD\|238640	cd01315, L-HYD_ALN, L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in biotechnology). But L-HYDs differ by having an L-enantio specificity and by lacking activity on possible natural substrates such as dihydropyrimidines. Allantoinase catalyzes the hydrolytic cleavage of the five-member ring of allantoin (5-ureidohydantoin) to form allantoic acid.	0
NZ_CP045929.1\|WP_154076708.1\|2499952_2501623_-\|PucR-family-transcriptional-regulator	gnl\|CDD\|377939	pfam07905, PucR, Purine catabolism regulatory protein-like family. The bacterial proteins found in this family are similar to the purine catabolism regulatory protein expressed by Bacillus subtilis (PucR). PucR is thought to be a transcriptional activator involved in the induction of the purine degradation pathway, and may contain a LysR-like DNA-binding domain. It is similar to LysR-type regulators in that it represses its own expression. The other members of this family are also annotated as being putative regulatory proteins.	1.51096e-27
NZ_CP045929.1\|WP_154078792.1\|2498512_2499523_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	1.06408e-72
NZ_CP045929.1\|WP_154076719.1\|2515641_2516520_-\|2-hydroxy-3-oxopropionate-reductase	gnl\|CDD\|183197	PRK11559, garR, tartronate semialdehyde reductase; Provisional.	1.06941e-102
NZ_CP045929.1\|WP_154076720.1\|2516757_2517564_-\|TIM-barrel-protein	gnl\|CDD\|163190	TIGR03234, OH-pyruv-isom, hydroxypyruvate isomerase. This enzyme interconverts tartronate semi-aldehyde (TSA, aka 2-hydroxy 3-oxopropionate) and hydroxypyruvate. The E. coli enzyme has been characterized and found to be specific for TSA, contain no cofactors, and have a rather high Km for hydroxypyruvate of 12.5 mM. The gene is ofter found in association with glyoxalate carboligase (which produces TSA), but has been shown to have no effect on growth on glyoxalate when knocked out. This is consistent with the fact that the gene for tartronate semialdehyde reductase (glxR) is also associated and may have primary responsibility for the catabolism of TSA.	1.05323e-89
NZ_CP045929.1\|WP_154076718.1\|2513671_2515372_-\|glyoxylate-carboligase	gnl\|CDD\|183066	PRK11269, PRK11269, glyoxylate carboligase; Provisional.	0
NZ_CP045929.1\|WP_154076712.1\|2504394_2506725_+\|xanthine-dehydrogenase-subunit-D	gnl\|CDD\|132240	TIGR03196, pucD, xanthine dehydrogenase D subunit. This gene has been characterized in B. subtilis as the molybdopterin binding-subunit of xanthine dehydrogenase (pucD), acting in conjunction with pucC, the FAD-binding subunit and pucE, the FeS-binding subunit. The more common XDH complex (GenProp0640) includes the xdhB gene which is related to pucD. It appears that most of the relatives of pucD outside of this narrow clade are involved in other processes as they are found in unrelated genomic contexts, contain the more common XDH complex and/or do not appear to process purines to allantoin.	0
NZ_CP045929.1\|WP_154076707.1\|2497718_2498513_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	3.52674e-87
NZ_CP045929.1\|WP_154076710.1\|2502527_2503007_+\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	1.84854e-66
NZ_CP045929.1\|WP_154076711.1\|2503003_2504398_+\|8-oxoguanine-deaminase	gnl\|CDD\|236184	PRK08203, PRK08203, hydroxydechloroatrazine ethylaminohydrolase; Reviewed.	0
NZ_CP045929.1\|WP_154076717.1\|2512455_2513619_-\|glycerate-kinase	gnl\|CDD\|376844	pfam02595, Gly_kinase, Glycerate kinase family. This is family of Glycerate kinases.	1.77393e-160
NZ_CP045929.1\|WP_154076709.1\|2501655_2502537_+\|xanthine-dehydrogenase-family-protein-subunit-M	gnl\|CDD\|224238	COG1319, CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion].	1.89436e-53
NZ_CP045929.1\|WP_154076722.1\|2518021_2518390_+\|transcriptional-regulator	gnl\|CDD\|379117	pfam13309, HTH_22, HTH domain. This domain is a helix-turn-helix domain that is likely to act as a DNA-binding domain.	1.21339e-25
NZ_CP045929.1\|WP_154076706.1\|2496720_2497722_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238568	cd01148, TroA_a, Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains.	2.57584e-91
NZ_CP045929.1\|WP_154076714.1\|2507718_2509182_+\|NCS2-family-permease	gnl\|CDD\|225161	COG2252, COG2252, Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism].	2.18585e-104
NZ_CP045929.1\|WP_154076713.1\|2506684_2507260_+\|nucleoside-deaminase	gnl\|CDD\|238612	cd01285, nucleoside_deaminase, Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on the substrate. The functional enzyme is a homodimer. Cytosine deaminase catalyzes the deamination of cytosine to uracil and ammonia and is a member of the pyrimidine salvage pathway. Cytosine deaminase is found in bacteria and fungi but is not present in mammals; for this reason, the enzyme is currently of interest for antimicrobial drug design and gene therapy applications against tumors. Some members of this family are tRNA-specific adenosine deaminases that generate inosine at the first position of their anticodon (position 34) of specific tRNAs; this modification is thought to enlarge the codon recognition capacity during protein synthesis. Other members of the family are guanine deaminases which deaminate guanine to xanthine as part of the utilization of guanine as a nitrogen source.	2.17815e-41
NZ_CP045929.1\|WP_154076724.1\|2519136_2519475_+\|hydroxyisourate-hydrolase	gnl\|CDD\|274364	TIGR02962, Probable_5-hydroxyisourate_hydrolase_R09H10.3, hydroxyisourate hydrolase. Members of this family, hydroxyisourate hydrolase, represent a distinct clade of transthyretin-related proteins. Bacterial members typically are encoded next to ureidoglycolate hydrolase and often near either xanthine dehydrogenase or xanthine/uracil permease genes and have been demonstrated to have hydroxyisourate hydrolase activity. In eukaryotes, a clade separate from the transthyretins (a family of thyroid-hormone binding proteins) has also been shown to have HIU hydrolase activity in urate catabolizing organisms. Transthyretin, then, would appear to be the recently diverged paralog of the more ancient HIUH family. [Purines, pyrimidines, nucleosides, and nucleotides, Other].	2.19855e-53
NZ_CP045929.1\|WP_154076716.1\|2510556_2510937_-\|gamma-glutamylcyclotransferase	gnl\|CDD\|236177	PRK08186, PRK08186, allophanate hydrolase; Provisional.	9.7842e-16

>NZ_CP045929.1|WP_154076714.1|2507718_2509182_+|NCS2-family-permease
MTHTDSTSRQPDHPDPTLPAASWVDRFFRITERGSSVARELRGGLTTFVAMAYIVILNPIILGSSSDVTGRVLTNAELTTATAFTAAFATVLMGLVGNAPLAMASGLGVNAIVAFTIAPVMTWQQAFGLVVLEGLCIIVLAVSGLRQKIIEAIPDALKIALTVGIGVYIALIGLVQAGFVSRVPDAAETTVPVQMGEQGHLQGAPIALFCATLLLMIVLMARQVRGAMLISIGVGTVGAVVMNSALGLSEDNWGLIQPTLPDSLIAAPDFGLFGQIDLVGGFAAAGGVTATVFLFTLVLSGFFDAMGTITSVANQAGLTRNGKVEGMGRILTVDGVAAAAGGVTGSSPNTVFLESAAGVGEGARTGLASVLCGGLFGVALLFTPIVSIVPTQAAAPALVVVGAMMMTQCRNLPWDDSDYVIPIFLTVTLIPFTYMITNGIGAGIVAFTVIKLAKGRARDLNWFVVVLAVVFGLYFGIEGIEALFAGQ
>NZ_CP045929.1|WP_154076713.1|2506684_2507260_+|nucleoside-deaminase
MFRSRPATSPASRENQHHTSEETFVNTSVQPTAAPATERQWMDRAIDLATTSVAGGGGPFGALVLRGGELVGTGNNQVTTLLDPTAHAEVTAMRHACRELDTFSLDGCVLVTSCEPCPMCLSSALWARMDRILFSASRDDAAYGGFDDRKFYDLFETKPRAVWPMQVEQVDVPHRTRPFEAWLAKDDRIDY
>NZ_CP045929.1|WP_154076712.1|2504394_2506725_+|xanthine-dehydrogenase-subunit-D
MSTRTTPTRTPQDLDDTIAGEIGDSPRRPDGTLKVRGEYAYASDLWAENMLWGATLRSPHPHARIVSVNTAPALAHPGVYAVLTHEDVPGRNLFGLKTVDQPVLAEDVVRYRGEAVALVAADHPETARRALDLVEVEYEVLEPVLDPESAAHDDDVPLLHPDSGDDRNIVRYQPIVSGDPDATADVVVAETYTVGMQDQAFLGPEAGLAVPGDDGGVDLYLATQDLHSDLRQTAAALDLPQNKVRMTLSGVGGAFGGREDLSIQIHVCMLALRTGRPVKLVYDREESFFGHVHRHPATMYYEHGATHDGDLVYMRAKLYFDGGAYASKTPVVVGNGTSLGTGPYVIPNVRIEGWGLYTNNPPCGAMRGLGAVQPAFAYESQMDKLADALGMDPVEFRARNAVRRGSVLHTGQILDYPAPVAELLDRVRNLPMPTEDSLDSDVRSLPGGASNTTRRENVVRGVGYSVIIKNVSYAEGADDYSTARVRLEIVGGEPMAMVHTAAAEVGQGLLTVQQQIARSELGLEKVTLHPNDTSVGEAGSSSASRQTYVTGGAVRNACAAVQERVFARVVERFGPGLGELSLSGGKIVSTTDGVLVDLVDLLGSDSVDETREYHHRRTFPMDPTTGQSALVHVQHAFSAHRAVVDVDTELGLMKVVQLDCAQDVGKAINPEAVVGQIHGGSAQGLGLAVMEEIHVRDGSIRNPSFTDYLIPTMVDMPSMQVDVLEHADPHAPYGVRGVGEPPTISATPAIVAAIRAATGRRLTHVPVTPGHITGIA
>NZ_CP045929.1|WP_154076711.1|2503003_2504398_+|8-oxoguanine-deaminase
MTATARVVLTGAAIATVDAAGTEYDEGHVIVEGDRVVAVAPGEPEFDPSARTVDASGCLITPGLVNTHHHLYQWLTRGRAQQSPLFDWLTELYPAWTALDEENTLAAATAGLAQLALSGCTTAADHHYVFPRHGGDVAGSVVAAADRVGTRLHLVRGSMDRGRAHGGLPPESLVEDTDEALAGTEAAIDRFHDPAPNAAVRVAVGPCSPFSVSDRLMRESASLARRRGVRLHTHLAETTEEHHRCLAEFARTPVEYADELGWLGPDVWLAHGVHLSPAAVARLAATGTGVAHCPSSNARLAAGTAPVRDLLAADASVGLGVDGAASNEHGGLGDEIRQAMLVARLRDGAQALTAREALWLATAGGARCLGRQHELGSVEVGKLADLAVWRVDGIGHAGIADPVAALAFGASPPLELLIQGGRTLVEAGELTTVPAGEVARDLAAASAAFAPTSATGTAPKEVLR
>NZ_CP045929.1|WP_154076710.1|2502527_2503007_+|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein
MRVNVTVNGRSHQADDVWEGESLLYMLRERLGLPGSKNACEQGECGSCTVYLDGVPACACLVAAGQAEGRDVGTVEGLADGAQLDPVQEAFVETGAVQCGFCTPGLLVAAHDLLERDPRPSDTDVREALAGNLCRCTGYEKILDAVRLASDRRAERSQA
>NZ_CP045929.1|WP_154076709.1|2501655_2502537_+|xanthine-dehydrogenase-family-protein-subunit-M
MDFLRPTSWADALAAKAEHPDALVIAGGTDVMVELNFDQRRPPALLDLGGVVDLTGWDVHDGRIRLGAAVPYARVITELGDRLPGLAIASRTVGSPQIRNRGTVGGNLGSASPAGDAHPPLLACGADVEVCSVRGTRTVSISEFFTGVKRNALEPDELVAAVHLDAASGPQQFSKVGTRNAMVIAVCTFALALHPRERTVGTGLGSAAPTPRRATEAEQFLAEELADTGRWDVPTALPDSVNGKFGDLAAAAAAPIDDVRGSSDYRKHAIRVLARRTLGWTWNDYCAGRQQCA
>NZ_CP045929.1|WP_154076708.1|2499952_2501623_-|PucR-family-transcriptional-regulator
MMQYTGRAGTRDSGGTHENTGNAGRRYCGFLQPAVERSAVRLRTLFDDPELGLRLLAGREELDREIRWVYTTDLRDPRRYLTGGELVLSGLMWRDGPEDSDAFVAALAEAGVAALVAGTARLGSTPRDLVNACRRRRVPLLELPVTVSFNSVSDRVILDVVAERSTPSRGRGPLVSAVADGADTGDLARLVASEWGTGCLIMSTMDRLVAEAGMTEELTAPARRMMIDAYLRASRAPVFVEPESESAMTVFGVGNADEARVADWFVAIPGAHEVDSAMVAELGTALALVRSRLDEGRRVAAQAVGTVLRLVTEGNGTQPEINAQLAALGHDTARPAWVVAAEVSDGPALTERMLAELAAALDLPAITGRTDDEVFAVLRAPDDPVAVLTELRRRVQALDPALGNATVSMGVSAAVPVNALRGAIEEARHARLLARHRLDRGARSTDSGSRSACVVDGSEIATHQLLLAAVPDTVQESFRRRLLRDLQDYDAEHQSDLINTLAVFLETACSWSRAASRLHVHVNTLRYRIKRVEEITGRDLGRFGDRVDLYLALELG
>NZ_CP045929.1|WP_154078792.1|2498512_2499523_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MLVLVVVLALSVLVAVASGPTSVALPETLRYVFAALTGDRIGSDEVATYSIVWEVRAPRVLLAVVVGAGLSVIGVAVQAMVRNALADPFILGVSSGASVGATTVVAFGVFASLGVYALSLAAFLGALAASVLVYLAARTRGELSPLRLVLVGVALAYGFQAVMSVMVFFSPHGDAARTVLFWLLGSLGAATWGSLPIAALAVAVAIVLLLGRSRSLDVLSLGDETAASLGVDTSSLRRTLFLITAVVTGALVAVSGAVGFVGLVLPHVVRIVVGSEHGRVLMIAPLAGGIFLVWVDLLARTVVAPRELPLGAITALVGVPVFITLMRRRGYLFGGR
>NZ_CP045929.1|WP_154076707.1|2497718_2498513_-|ATP-binding-cassette-domain-containing-protein
MRVEFDAVTVRMAGRTVVDRLTLDVRSGEVVGLVGPNGSGKSTALRCLFGALRPTSGVVRVGGADVASVSLRDNARRVAALTQESRTELDFTVREIVELGRYPHLRGNRRLTARETEVCKDALRAMDLLALTERSVVGLSGGERQRVFLARALAQEPEVLVLDEPTNHLDVRHQIALLSYLRGCGRTVVVALHDLNLAAATCDRVAVLGDGMLREFAEPGLALRTELIRTVFGVEATSITHPATGDPQVLYALSRPSTSEEATS
>NZ_CP045929.1|WP_154076706.1|2496720_2497722_-|ABC-transporter-substrate-binding-protein
MNHHETNRAYAAAALASCLLATGCGAQVQPESEAGPPPVTVNNCGKDVTYPLPERPVAYDMSATEKMFALGLADQLRGIVLPSTAEAPASRSPFRKDYESVDVLGTDVLSREVVVEAKADWVLAGWNSGFSQERGITPALLEQVGIQSYLFTESCFNYGAEPVRVPPLEALYTDLRQIGTIFRVPDRAAKVVADLQRRAQALRSDRPEGDPANVFVYDSGTDQPFTSGTQAAPSAIIDLAGGEHVPRDLHERWTNVGWESVVAAQPDVITVVDYGDQPVRDKIEFLKSFPPLARTPAVRENRFHVLDYGEAVSGPRNLDAAEDLAAYLRSVGR
>NZ_CP045929.1|WP_154076716.1|2510556_2510937_-|gamma-glutamylcyclotransferase
MALMFLSGGGMRGGKLHHRIEGAPFVGPARTAPRYRMYSVADQFPAVEYVGDGGVSVQGELYDLPLEMLRTQLMPAEPAELELGLIELADGASSLATVLRGNWSGAEGLTDISHVASWRAHLGLDS
>NZ_CP045929.1|WP_154078793.1|2511038_2512385_-|allantoinase-AllB
MDRAFRAPRLIGEQGETSGWVGVRNGRIVAVEPFDRPLEADEVIELGTDEVLLPGLVDTHVHVNDPGRSEWEGFETATRAAAEGGITTIVDMPLNSLPPTVDAEALEVKRKTAREKVHVDVGFWGGAISGNLDSLRELHDDGVFGFKCFLLHSGVDEFPPLDPAELEKALSVLTGFGAMMIVHAEDSDSIEHAPVAHGEEYGRFLASRPRGAENLAIAQVIELARRYDARVHILHLSSSDALPMIASAKADGVRITVETCPHYLCFTAEEIPDGATPYKCCPPIREAGNRERLWQGLADGTIDCIVSDHSPCTAELKKMDIGDFGVAWGGVSSLQLGLSAVWTQARLRGYALTDVVDWMAHRTADLAGLRQKGAIEVGRDADLCVFAPDDAYVVDAARLRHRNPVSAYDGRALAGVVRGTWLRGERIVGPDIDSPGQRGQLLDRDAVR
>NZ_CP045929.1|WP_154076717.1|2512455_2513619_-|glycerate-kinase
MSGRVLIAPDKFKGSLSASEVAEAVAGGVRRVRPAADIRCLPVADGGEGTVQAAVACGWRRVPVLVGGPLGAPLHTEFAIDGDTALVELASASGLQQLPAGTSAPLTSSSAGTGELIRAALDAGARTVVLGVGGSACTDGGAGMLGALGAGVLDASGRVLPPGGGSLSDVSTVELAGLDPRLADTTVILASDVDNPLLGPRGAARVYGPQKGASPEDVQALQAGLGSWSDAVSRAGGRDTADSAGAGAAGGVGYAALAVLGATQRPGVDVVLELVRFRDALDGARLVVTGEGAVDEQTVHGKAPAGVARCARESGVPVVAVAGQCSLPRARLSEAGFDAAYVLAELEQDPQRCLRDAARLLDRLGAALAHDWLPEAEGVTEVLAADS
>NZ_CP045929.1|WP_154076718.1|2513671_2515372_-|glyoxylate-carboligase
MPTVPAMQAVVDVLESEGVDVSFGCPGAAILPLYAAMEHRDIRHLIVRHEEGATHMADGWARTNGKVGVAIGTSGPAGTNMITGLYTAHADSIPMVCITGQAVSSKLHQEAFQAVDIVEIAKPVTKWSVQVKEAAQAPWIFREAFRIAKSGRPGPVLIDLPLDVQKQEIEWDPAIDAPLPVKAVEPHLPRVEKALDMLLEAERPLILAGGGVITGEAHEQVRELAELLGIPVQVTLMGKGTFPEDHELFAGMTGIQTSQRYGNESFLRSDLVLALGSRFGDRHTGALDVYRGQRRFIHVDIEPTQLGKVFGPDLGIVSDTRLFLDALLDAARRRAADTDYGTWVREVGELKTTLTRPDDYDSVPIKAPRVFRDINAVFGPETYFVTAIGLYQIWSGQFQTTHRPRHYQVCGQAGPLGWEIPAAIGVKSAEPDAEVVAVVGDYGFQFLVEELAVAAQYDVPFVIIMLNNEYLGLIRQAELEYSMNTEVDIHHDEYGTDNVKVAEAFGGSGRRVFDPADLTETIEWARKEAVATSRPVLVEVMIEREANTPRGASIDAMIEPEAVPNA
>NZ_CP045929.1|WP_154076719.1|2515641_2516520_-|2-hydroxy-3-oxopropionate-reductase
MTTIGFVGLGIMGGPMAANLVKAGYFVVGTNLSRPKIDWLVEQGGRGADSIAEAVKDADVVITMLPDSPDVEAAALGDEGILAHARQGALYIDCSSIRPDTSRAVADAAASKGVRTLDAPVSGGEPKAIDGTLSLMVGGEPETFEAGREFLETVGSTIVHVGPAGSGQTVKIANQLIVAGNIGLLAEALLYLEAHGVDTEAGMRALGGGLAGSAVLDAKAEKMRSREFNPGFRIELHDKDLGNLEVSARQAGLALPIGALVTQVVAAAKAQGDGSLDHSGLFRQLAQLSGRD
>NZ_CP045929.1|WP_154076720.1|2516757_2517564_-|TIM-barrel-protein
MGRDRYDVNLSILYTELDLLERPAAAKAAGFDAVEFWWPFASAAPADREVDAFAEAIEQAGVELVGLNFFAGDMPSGDRGVLSHPDRESEFTDSVQIAVGLGERLGCRAFNALYGNRLDGQDPSAQDEVAVQNLARAAKASSRIGGTVLVEPVSGVAAYPLQTAEDAMGVIDRTHRESDVDNLRLLFDLYHLVANGDDPDAALDRYARSIGHVQIADAPGRNEPGTGNLDFVHYFSALTAAGYRGHIGLEYKPSGASADSFGWIEKIG
>NZ_CP045929.1|WP_154076721.1|2517753_2518014_+|hypothetical-protein
MILRAEFTTEPFETEGEPPSHALAARDCLEKTGLRADFGPLGTSTTGEQATVVSALSSVIDTALAHGAHQITLQVTVEGATAGDEA
>NZ_CP045929.1|WP_154076722.1|2518021_2518390_+|transcriptional-regulator
MHPLASAIAPLLDTIGATAHPAENSEPGDIVLHWDGAPAVAVRLPGAELTSALDRLIHQVEAELGAPLPELGRPDKQRAVRLLEERGAFTLRKSVESVAQALGVSRFTVYNYLNRENTRSQD
>NZ_CP045929.1|WP_154076723.1|2518612_2519140_+|2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline-decarboxylase
MSTPRTRDRGQTPHQLNAMPRTDLLAHLLACLDVPRWAEAVADSRPFPDRTAVHDAAERAARPLSAEEIHRALAAHPRIGERVEGSGTSASFSRGEQGGVDAGDADLTRALHDGNAEYERRFGHVYLVCASGRSGTELLEILHARLDNDHDTELAVVADELRAIATLRLDKVIAA
>NZ_CP045929.1|WP_154076724.1|2519136_2519475_+|hydroxyisourate-hydrolase
MTSAVTTHVLDAARGAPATDITVHLEAADGDKWVSMAEAATDSDGRVRELGPQQVDPGTYRLTFETGEYFRRNEVDTFYPQVQITFAIRDAAQHYHVPLLLSPFAYSTYRGS

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Crispr_ID: NZ_CP045929_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045929_6

3200984-3201115

Orphan

Consensus_repeat	Method
CGAACGGCACTCTCGCCCCACGAGACGAGGCGAAAGTGCCGTTCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP045929_6

>merge|NZ_CP045929|6|3200984-3201115|CRISPRCasFinder
CGAACGGCACTCTCGCCCCACGAGACGAGGCGAAAGTGCCGTTCGCTCCATCACACACAGCGAAGCAGCGCCGCGCGGTAAAGGTACGAACGGCACTTTCGCCCCACGAGACGAGGCGAAAGTGCCGTTCGC

>NZ_CP045929|6|6|3200984-3201115|CRISPRCasFinder
CGAACGGCACTCTCGCCCCACGAGACGAGGCGAAAGTGCCGTTCGC	TCCATCACACACAGCGAAGCAGCGCCGCGCGGTAAAGGTA
CGAACGGCACTTTCGCCCCACGAGACGAGGCGAAAGTGCCGTTCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045929.1\|WP_154077235.1\|3208535_3209384_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379312
NZ_CP045929.1\|WP_154077226.1\|3193037_3193796_-\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|235975
NZ_CP045929.1\|WP_154077234.1\|3206672_3208208_-\|30S-ribosomal-protein-S1	unknown	unknown	gnl\|CDD\|236126
NZ_CP045929.1\|WP_154077227.1\|3194031_3194616_+\|DNA-binding-protein	unknown	unknown	unknown
NZ_CP045929.1\|WP_154077237.1\|3211204_3211648_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319916
NZ_CP045929.1\|WP_154078874.1\|3205716_3205938_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045929.1\|WP_154077222.1\|3189468_3190470_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235082
NZ_CP045929.1\|WP_154077233.1\|3206070_3206544_-\|YbaK/EbsC-family-protein	unknown	unknown	gnl\|CDD\|239825
NZ_CP045929.1\|WP_154078871.1\|3194736_3195345_+\|RES-domain-containing-protein	unknown	unknown	gnl\|CDD\|378053
NZ_CP045929.1\|WP_154078873.1\|3200195_3200975_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224196
NZ_CP045929.1\|WP_154077232.1\|3204625_3205531_-\|dephospho-CoA-kinase	unknown	unknown	gnl\|CDD\|179560
NZ_CP045929.1\|WP_154077223.1\|3190546_3191533_-\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176203
NZ_CP045929.1\|WP_154077228.1\|3195465_3196503_-\|TerC/Alx-family-metal-homeostasis-membrane-protein	unknown	unknown	gnl\|CDD\|274743
NZ_CP045929.1\|WP_154077236.1\|3209527_3210481_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_CP045929.1\|WP_154077224.1\|3191569_3192178_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380061
NZ_CP045929.1\|WP_154077229.1\|3201130_3203278_-\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NZ_CP045929.1\|WP_154077230.1\|3203352_3203901_+\|DUF402-domain-containing-protein	unknown	unknown	gnl\|CDD\|225188
NZ_CP045929.1\|WP_154078872.1\|3196881_3199677_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|224054
NZ_CP045929.1\|WP_154077225.1\|3192264_3193041_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_CP045929.1\|WP_154077231.1\|3204081_3204588_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225188

Protein	Function_ID	Function_description	E-value
NZ_CP045929.1\|WP_154077235.1\|3208535_3209384_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	5.38788e-21
NZ_CP045929.1\|WP_154077226.1\|3193037_3193796_-\|glucose-1-dehydrogenase	gnl\|CDD\|235975	PRK07231, FabG-like, SDR family oxidoreductase.	5.22959e-113
NZ_CP045929.1\|WP_154077234.1\|3206672_3208208_-\|30S-ribosomal-protein-S1	gnl\|CDD\|236126	PRK07899, rpsA, 30S ribosomal protein S1; Reviewed.	0
NZ_CP045929.1\|WP_154077231.1\|3204081_3204588_+\|hypothetical-protein	gnl\|CDD\|225188	COG2306, COG2306, Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only].	2.19774e-08
NZ_CP045929.1\|WP_154077237.1\|3211204_3211648_-\|VOC-family-protein	gnl\|CDD\|319916	cd07253, GLOD5, Human glyoxalase domain-containing protein 5 and similar proteins. Uncharacterized subfamily of VOC family contains human glyoxalase domain-containing protein 5 and similar proteins. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	4.62564e-60
NZ_CP045929.1\|WP_154077222.1\|3189468_3190470_-\|hypothetical-protein	gnl\|CDD\|235082	PRK02888, PRK02888, nitrous-oxide reductase; Validated.	0.000320431
NZ_CP045929.1\|WP_154077233.1\|3206070_3206544_-\|YbaK/EbsC-family-protein	gnl\|CDD\|239825	cd04333, ProX_deacylase, This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro) deacylase and also the cis-acting prolyl-tRNA synthetase-editing domain (ProRS-INS). While ProX and ProRS-INS hydrolyze misacylated Ala-tRNA(Pro), the E. coli YbaK hydrolyzes misacylated Cys-tRNA(Pro). A few CD members are N-terminal, YbaK-ProX-like domains of an uncharacterized protein with a C-terminal, predicted Fe-S protein domain.	1.19387e-53
NZ_CP045929.1\|WP_154078871.1\|3194736_3195345_+\|RES-domain-containing-protein	gnl\|CDD\|378053	pfam08808, RES, RES domain. This presumed domain contains 3 highly conserved polar groups that could form an active site. These are an arginine, glutamate and serine, hence the RES domain. The domain is found widely distributed in bacteria. The domain is about 150 residues in length.	8.38743e-11
NZ_CP045929.1\|WP_154078873.1\|3200195_3200975_+\|ABC-transporter-permease-subunit	gnl\|CDD\|224196	COG1277, NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only].	1.80696e-06
NZ_CP045929.1\|WP_154077232.1\|3204625_3205531_-\|dephospho-CoA-kinase	gnl\|CDD\|179560	PRK03333, coaE, dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional.	3.22471e-116
NZ_CP045929.1\|WP_154077223.1\|3190546_3191533_-\|zinc-binding-dehydrogenase	gnl\|CDD\|176203	cd08241, QOR1, Quinone oxidoreductase (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	2.03506e-142
NZ_CP045929.1\|WP_154077228.1\|3195465_3196503_-\|TerC/Alx-family-metal-homeostasis-membrane-protein	gnl\|CDD\|274743	TIGR03718, R_switched_Alx, integral membrane protein, TerC family. Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family often are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains TerC itself from Alcaligenes sp. plasmid IncHI2 pMER610 and from Proteus mirabilis. It also contains the alkaline-inducible E. coli protein Alx, which unlike the two TerC examples is preceded by a yybP-ykoY leader.	5.37204e-143
NZ_CP045929.1\|WP_154077224.1\|3191569_3192178_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|380061	pfam17932, TetR_C_24, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.	1.34775e-28
NZ_CP045929.1\|WP_154077229.1\|3201130_3203278_-\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NZ_CP045929.1\|WP_154077230.1\|3203352_3203901_+\|DUF402-domain-containing-protein	gnl\|CDD\|225188	COG2306, COG2306, Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only].	8.82827e-30
NZ_CP045929.1\|WP_154078872.1\|3196881_3199677_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	6.05382e-90
NZ_CP045929.1\|WP_154077225.1\|3192264_3193041_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.50192e-47
NZ_CP045929.1\|WP_154077236.1\|3209527_3210481_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	1.20786e-05

>NZ_CP045929.1|WP_154078873.1|3200195_3200975_+|ABC-transporter-permease-subunit
MQRQLRRRRTGITLTFLALLPVLVWAAFALGGNDDDGSRLVDFATSSGLNFATFTLFASANFLLVVVVALFFGDTVASEASWSSLRYLLAAPIPRARLLRQKALVAASLSGIGLLLLALVALGIGIVVHGGGQLVSPGGQALDLLPGVVSFAGAVLYVAVNLTWVAGLATWLGVATDAPLGAVGGAVVVSIVSTILDQITALGALRSFLPTHYATAWRDLLSDEVDWANMINGTATSLAYATAFGVLAVLHFSRRDVTS
>NZ_CP045929.1|WP_154078872.1|3196881_3199677_+|alpha/beta-fold-hydrolase
MVGFVLAGAMLWPREDEAAPTPPPPRHALIDVVDGPSRGERVQIDATLYSPVETPAPAVLLTHGFGGDKNSLADQARELAARGFTVLTYSARGFGRSTGKIALNAPEYEVTDARQIVDWLARQPEVRRDGDNDPRIGVGGASYGGALSLLLAGSDPRVDAVAGMTTYNDLGQALLPNAASSRPIPARTPAHGSFGPNGVFKQSWAGLLFAAGAHGNGASPPGNGPRQGAGAGPSTAQPPTPRPPRPDTQTSTCGQFTEAVCAAYVEIAQNGAPGPRAQALLDRVSPQRVADRITAPTLLVQGTRDTLFGLDQADANARQIAASGTKTKVVWFSGGHDGAAPGPQVRHRIGDWFAFHLGGVPPVPDPGTSFEYEVNGPPRRNSDGSVRTVTAPTYPGIGGAERSARFTLPLSGDLARVVNPPGGSPAATSSLPGVGAGEDSPEQLGRALAMEVPGQVATFRTEPLTSQLVVSGAPQTRLAISAVPGEPNTGQAVLFAKLYDVAPDGTKTLTGNNVAPIRVTGIPQDGTPVEVNVALPGVVQSVEAGHRLELAVSTTDQAFATPEEAAVHRVGLAGPNAVSVPAVRGATAATHTVPLVPLAVIGGLLLLLLLVGALGRLLARWPARGDKALAGTPLALSDVSKWYGRRAAAVNDMSLRVERGQVVGLLGPNGAGKSTTLRMLLGLVRPTSGEIRMFGHKVRPGAPVLSRVGALVEGPGFLPHLSGVDNLRSYWAATGRPLLQARIDEALDIAELGPAARRPVRTYSQGMRQRLAIAQAMLGLPELLVLDEPTNGLDPAQIHQMRELLRRYAATGRTVVVSSHLLSEIEKICTHVVVMHEGRLVTAGSVEDVVTVDGGATFRVDEPERAADTLRSIEGLGTVETDGNLVHADLAGHTPAVAVNALVATGIAVNQVGPRHRLEDAFLQLVGEEQR
>NZ_CP045929.1|WP_154077228.1|3195465_3196503_-|TerC/Alx-family-metal-homeostasis-membrane-protein
MGAPTTVPLQSTALAQAQTDTLNVSWWVWAATLAGLAVLLLIDLVIVDRKPHEVSTSEAAKWVVFYIGCAIAFGLGVWFFGDGHFAIEYFTGYITEYSLSVDNLFIFMVIMSGFAVPAIHQHRVLLIGIVLALVMRGIFIAVGAALIARFVWIFFIFGAFLIWTALSMVRNKDDEDDDPENAVVRWVRKLFPVTDDYHGAKSSVKIDGKRYLTPMFVVIVAIGSADLLFAVDSIPAIFGITQDPFLVFAANAFALMGLRQLYFLLGGLVNKLVYLSTGLAVILGFIGVKLIIHAFHEYHLVPEWLEINNWMSLGFIVLTLAITTYLSLQKSKRDAQQVESGTDQG
>NZ_CP045929.1|WP_154078871.1|3194736_3195345_+|RES-domain-containing-protein
MLRRTEDVIAVPAGTRLVRVFTTGGNHPQQWDSFRYAGPLPHARFDPHLPNSRGGPSVTREHGVLYFSLSVRTCVAEVFQATSTVDRSSRSPHLVVFRPRRTLRLLDLSGLWPTRAGASQAISSGPKERTQAWARSIRAAHPELDGVWYCSSMDGGDPSLCLWDPPSADAMPEAPDVLLPLDHPGLDVPLGRVCEELSYTLL
>NZ_CP045929.1|WP_154077227.1|3194031_3194616_+|DNA-binding-protein
MTVALETVLARAGLRVTATEFLSLVEDAAKKLTPAQQQPSTQFSSAERAALADVGLDLSPVDADEHDARARTVAEQAVMRDTALSVNQAAARIGVDTSRIRHRIGSGRLVGWKDRGGWRLPAWQFTDADVLPGLDSVLLAVPIDQPALVLAKFMTTPQDDLLLGDRPVSPREWLMAGGSAERVATQAAMLGTPA
>NZ_CP045929.1|WP_154077226.1|3193037_3193796_-|glucose-1-dehydrogenase
MDKRFDGQVAIVTGSSRGIGYGIAERLVSEGAQVCLTARKDGPLDEAVEALGGADRALGVAGKADDPDHQADTVARTLDTFGRVDMLVNNTGINPAYGPLVDLDHGVARKTFEVNALGALSWVQQVHRAWMAEHGGTVLNVASVAGKRPAPHIGFYGATKAMLLSITQQLALELGPDIRVNALAPAVVKTRFATALYEGKEEDVAASYPLKRLGAPDDISGAAAFLLSEADAGWVTGQTLVLDGGLTLTGGV
>NZ_CP045929.1|WP_154077225.1|3192264_3193041_-|SDR-family-NAD(P)-dependent-oxidoreductase
MTVELTGKVVLVTGAAHGIGAALSRAFAERGAHVVAGDLDAEALHGLCAEIGAQAVAGNAADAQDVGNLVDTALAEHGRIDLFCANAGVDHAGGPEALDETWDHAWDVNVMAHVRAARAVLPHWLERGQGRFVSTVSAAGLLTMLGSAPYSVTKHAALAFAEWLAITYADRGITVQALCPQGVRTDMLARCGKQGQQILADSAVGVETVVESVLEALQDDRFLILPHPEVARYYAARAGDPDKWQGSMRKLQRMLDAG
>NZ_CP045929.1|WP_154077224.1|3191569_3192178_-|TetR-family-transcriptional-regulator
MARAANAGTDSVPQRLLAAATTLFADHGFEATSVQRIVDAAGVTKGAMYHYFDSKDDLLHEIYARVLRVQTARMEQAVASTDPVDRRLHAVAADVVVTTADNLDDTVIFFRSMHMLHPDTQAEVRAQRRRYHERVRELVEEGQRAGVFRDDKPADLVVDYFFGSVHHLGSWFRPDGEWTPEQVGEHFADLLLDALRSPSPRS
>NZ_CP045929.1|WP_154077223.1|3190546_3191533_-|zinc-binding-dehydrogenase
MYAWQLTELGSPRDVLRLVEIDRPEPGPGQLVVRVLASTVNFPDVLLCRGEYQVSPELPFTPGVELCGEVVELGSEVSGVSVGDHVIGGAALPHGGFGEYAVIQADRALPAPESLSPAEGASLYIGYQTAWFGLHRRAGLSEGETLLVHAAAGGTGSAAVQLGKAAGSRVVAVVGGPDKAAIARELGADVVVDRHREDFVSVVKDLTGGRGADVVYDPVGGETYTRSTKCIAFEGRILVIGFAGGTIPTPGLNHALIKNYSILGLHWGLYTERAPQAVVQVHTELRRLAAEGAVRPLISEKVSLENLADAVQRVGDGHTVGRVALVRQ
>NZ_CP045929.1|WP_154077222.1|3189468_3190470_-|hypothetical-protein
MGRGPCGRVRSVRAGHESERHVRDRTVGRRRFLAWAAGLAAGGVAAGCSAPAAAPGPQATPPLRLPAPEIWPPAEPAPQITPENTPTTITELVYSEFRQASVGLTVTYPSGVTNTENLPMVLSLHGRDGPVPTATPFGTLAAMESEYQAGTIPAFGFVSVDGGYNAYWNNGSLNGELMSMIQDEIPRWLLERGLGEAGTGLPYACVGLSTGGFGAACYAIERNRRGIPLEAVGLLAPALMTDWKEVEVRQAFPSEQVWRSHDPLLRLDELGDVPVAVWIGDKDHFFDGTMQLVAGHENTPVVTILPGAHDGSVFDATGLEAVHFLSRDKPVEG
>NZ_CP045929.1|WP_154077229.1|3201130_3203278_-|excinuclease-ABC-subunit-UvrB
MAFATEYPVLAQSEFRPVTDIPRKGGRFEVVSDYQPAGDQPEAIADLKRRIDAGETNVVLLGATGTGKSATTAWLIEQVQRPTLVLEPNKTLAAQIANEMRGFFPDNAVEYFVSYYDYYQPEAYVPQTDTYIEKDSSINEDVERLRHSATSNLLSRRDCVVVSSVSCIYGLGTPQSYLDRSIQLEVGGEIDRDLLLRTLVDVQYTRNDIAFARGTFRVRGDTVEVIPAYEELAVRIEFFGDEVERLYYLHPLTGEIVREVDDLRIFPATHYVAGPERMEKAIHDIEAELEERLGELEKQNKLLEAQRLRMRTQYDIEMMRQVGFCSGIENYSRHIDGRPAGSAPATLLDYFPDDFLLIIDESHVTVPQVGGMFEGDMSRKRTLVEHGFRLPSAVDNRPLTWEEFADRIGQTVYLSATPGPYEMGRAGGEFVEQVIRPTGLVDPEVVVKPTEGQIDDLVHEIRERAERDERVLVTTLTKKMAEDLTDYFLELGVRVRYLHSEVDTLRRVELLRQLRLGEFDVLVGINLLREGLDLPEVSLVSILDADKEGFLRSETSLVQTIGRAARNVSGQVHMYADTVTDSMRRAIDETNRRRAKQIAYNTEHGIDPQPLRKKIADILDRVYDEAEDNVEVGGSGRNASRGKKPTGEAVATSGVLEDRDTKSMPRAELADLIQQLNDQMMNAARDLQFELAARLRDEIHDLKKELRGMDAAGIE
>NZ_CP045929.1|WP_154077230.1|3203352_3203901_+|DUF402-domain-containing-protein
MTTQREIADQLGLPIHPPKVEVFDLTDSTNTDPKSRVRTVDEYRVEPFGLYMARSMEGHATLRYVRSWLLPALDLRVSIFDWNPGHGHDQDFYLDIAEVEPGAQRWHTRDLYLDISVGTGRFARVLDVDEFLLASRSALLDPATSQRAMESTHRAVDGIAAHGYDLDRWLATHGVELSWSRA
>NZ_CP045929.1|WP_154077231.1|3204081_3204588_+|hypothetical-protein
MSTAITPQLADVVDVFGAERVHSSGSRHPLTHCHIEPWGLSYSCPTPEDPAHDSEVTWLLPALGLRLTQFRPRRRHARRESTELTAVHVQRDTRSWRTTDLLLGLEVPDRSSARIIRSEEFAAAVSGGVIRLSEADYALRTVHRTLEEVTLHRDLQQWLAHRGIYDPW
>NZ_CP045929.1|WP_154077232.1|3204625_3205531_-|dephospho-CoA-kinase
MLLIGLTGGIGSGKSTVAGRFAELGAVVVDADRIAREVVEPGTPGLAEIVDRFGSEVLDADGALDRPAMAAKVFGDDDARAALNAITHPRIAERSAERFAAAPGDAIVVHDMPLLVELDMTPNYHLTVIVDAPEDVRVRRLSGRGVEESDARARIRAQATEEQRRAVADVWLDNSGTREQLLDSVETVWWRRLVPFEENVRLRRGAGRPAEGDTGSESMVRRVRARLERLTGEHAGVVESAGFGADDPIDFRVAVSAEDVEQVGEALAAGGFPRSGFDDQDRVHVPADPCLPVTVRLSASR
>NZ_CP045929.1|WP_154078874.1|3205716_3205938_+|hypothetical-protein
MLGRVRKPGRHRLGTPGLTHCSDHPTVSGALAVHRRRWISGLLVPAKHSLAGLRRRAVAAARARAWAPTVATA
>NZ_CP045929.1|WP_154077233.1|3206070_3206544_-|YbaK/EbsC-family-protein
MSVGRRARQFQNRLGEMGLDLEVVEMPDSTRTAADAARALNCEQAQIVKSLVFRTEPGDAPVLVLVSGVNRVDEAALSRVLGTNLAKADAAYVKKVTGFSIGGVPPLGHSSSMTLLVDEDLLRFDATWAAAGSPNAVFRIPGRVTDFLPPHTVGPVR
>NZ_CP045929.1|WP_154077234.1|3206672_3208208_-|30S-ribosomal-protein-S1
MSTDTTTVPTDAAPQQQQVAVNDVGTAEDFLAAIDKTIKYFNDGDIVEGTIVKVDRDEVLLDIGYKTEGVIPSRELSIKHDVDPAEVVEVGDFVEALVLQKEDKEGRLILSKKRAQYERAWGTIENLKDSDEPVKGSVIEVVKGGLILDIGLRGFLPASLVEMRRVRDLQPYVGRELEAKIIELDKNRNNVVLSRRAWLEQTQSEVRSEFLNQLQKGQVRKGVVSSIVNFGAFVDLGGVDGLVHVSELSWKHIDHPSEVVEVGQEVTVEVLDVDMDRERVSLSLKATQEDPWRQFARTHAIGQIVPGKVTKLVPFGAFVRVEEGIEGLVHISELAERHVEIPEQVVQVNDDAMVKVIDIDLERRRISLSLKQANEGFTPDSEFDPTQYGMAAEYDAEGNYIYPEGFDVETQEWQEGFEKQREEWERQYGEAHARYEQHMKQVQKAAEADAEAAAAGAAEEQGGNYSSSAPAAENQQQQPQQQPQQQQQDDGGSLASDAQLAALREKLSGGA
>NZ_CP045929.1|WP_154077235.1|3208535_3209384_+|methyltransferase-domain-containing-protein
MTSGDAEHASAEQLLGTVGVSTREVSAAESRTASRLWWDADADDYQNEHGDFLGLSDFVWCPERLREAEAGLLGEVAGARVLEVGCGSASCARWLRLQGAEVVAMDISAGMLRHAADGNSAGGVEVPLVQASADVLPFATESFDVACSAFGGVPFVADSGAVMHEVARVLRPGGRWVFSVTHPMRWIFPDDPGPEGLTAIQSYFDRSPYVEIDESDRATYVEHHRTLGDYVRQLNAAGLRLVDLVEPEWPEDLTAIWGQWSPLRGRLFPGTSIFSCVLEPST
>NZ_CP045929.1|WP_154077236.1|3209527_3210481_+|GNAT-family-N-acetyltransferase
MTTAQALMDSQVARLRTLDPRLPSTYRLPSGEPVMARLRDGSGVAGIAVRTSHRPGSLQSLWSASESAELFPLLGDHPREGMDALLHAWREQLADEGMPDRDSSCVVTWPSRDVEATRALLDHGFTPLSCLAVRSTPPGDAELIPRPPGTVTIRRAGPDDLDTVVEFTLKELEYAALVGASVHRPDAATLKRTAAHVRLHGSGPDGRDPVWIAERDGVPVGLAECGWTDTAQHHSGRRLRPGRWAYVNCVSVDEQARATGVGRELMATAHHEFARAQVLGSYLYYNPPNPLSSVFWPRQGYRPLWTIWEVRPATAVR
>NZ_CP045929.1|WP_154077237.1|3211204_3211648_-|VOC-family-protein
MINIDRVDHLVLTVADVDRAVDFYELILGMKAQTFPGDRRAVSFGQQTVKLHAASELVEPTATHPVPGSANLCFVTSSAISEVQAHLRSNDVRIEEGPVARTGSLGPITSLYVRDPDGNLIEIARYDDPIDEPAVDPLDAVEALPQD

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Crispr_ID: NZ_CP045929_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045929_7

3617148-3617294

Orphan

Consensus_repeat	Method
CGAGGCGAACGGCACTTTCGCCCCACCACA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP045929_7

>merge|NZ_CP045929|7|3617148-3617294|CRISPRCasFinder
CGAGGCGAACGGCACTTTCGCCCCACCACACGAGGCGAACGGCACTTTCGCCCCACCACACGAGGCGAACGGCACTTTCGCCCCACCACAGCGGCTGGAGACCTCCGCCTACTGGGACGGGGCGAACGGCACTTTCGCCTCATCACA

>NZ_CP045929|7|7|3617148-3617294|CRISPRCasFinder
CGAGGCGAACGGCACTTTCGCCCCACCACA	CGAGGCGAACGGCACTTTCGCCCCACCACA
CGAGGCGAACGGCACTTTCGCCCCACCACA	GCGGCTGGAGACCTCCGCCTACTGGGA
CGGGGCGAACGGCACTTTCGCCTCATCACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045929.1\|WP_154077533.1\|3605824_3606235_+\|YjbQ-family-protein	unknown	unknown	gnl\|CDD\|223509
NZ_CP045929.1\|WP_154077545.1\|3623107_3626710_+\|cobaltochelatase-subunit-CobN	unknown	unknown	gnl\|CDD\|235663
NZ_CP045929.1\|WP_154077549.1\|3630682_3631999_-\|precorrin-methylase	unknown	unknown	gnl\|CDD\|235610
NZ_CP045929.1\|WP_154077534.1\|3606319_3607171_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|183743
NZ_CP045929.1\|WP_154077548.1\|3629010_3630078_-\|nickel-transporter	unknown	unknown	gnl\|CDD\|273277
NZ_CP045929.1\|WP_154077544.1\|3620711_3621404_-\|precorrin-8X-methylmutase	unknown	unknown	gnl\|CDD\|181352
NZ_CP045929.1\|WP_154077542.1\|3618469_3619222_+\|cobalt-precorrin-6A-reductase	unknown	unknown	gnl\|CDD\|236144
NZ_CP045929.1\|WP_154078923.1\|3609338_3610610_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP045929.1\|WP_154077547.1\|3627689_3628916_-\|uroporphyrinogen-III-C-methyltransferase	unknown	unknown	gnl\|CDD\|381169
NZ_CP045929.1\|WP_154077536.1\|3610702_3611449_+\|peroxide-stress-protein-YaaA	unknown	unknown	gnl\|CDD\|234999
NZ_CP045929.1\|WP_154077532.1\|3604640_3605675_-\|aminotransferase	unknown	unknown	gnl\|CDD\|223594
NZ_CP045929.1\|WP_154077539.1\|3615144_3616371_+\|precorrin-6y-C5,15-methyltransferase-(decarboxylating)-subunit-CbiE	unknown	unknown	gnl\|CDD\|225151
NZ_CP045929.1\|WP_154078924.1\|3621400_3622642_-\|precorrin-3B-synthase	unknown	unknown	gnl\|CDD\|274131
NZ_CP045929.1\|WP_154077540.1\|3616367_3617141_+\|precorrin-4-C(11)-methyltransferase	unknown	unknown	gnl\|CDD\|225430
NZ_CP045929.1\|WP_154077537.1\|3611673_3612714_-\|TerC/Alx-family-metal-homeostasis-membrane-protein	unknown	unknown	gnl\|CDD\|274743
NZ_CP045929.1\|WP_154077538.1\|3613527_3615042_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223587
NZ_CP045929.1\|WP_154077543.1\|3619209_3620715_-\|precorrin-2-C(20)-methyltransferase	unknown	unknown	gnl\|CDD\|381173
NZ_CP045929.1\|WP_154077535.1\|3607376_3609113_-\|proline--tRNA-ligase	unknown	unknown	gnl\|CDD\|236405
NZ_CP045929.1\|WP_154077546.1\|3626758_3627646_-\|class-A-beta-lactamase	unknown	unknown	gnl\|CDD\|185339
NZ_CP045929.1\|WP_154077541.1\|3617330_3618419_-\|cobalt-precorrin-5B-(C(1))-methyltransferase	unknown	unknown	gnl\|CDD\|234615

Protein	Function_ID	Function_description	E-value
NZ_CP045929.1\|WP_154077533.1\|3605824_3606235_+\|YjbQ-family-protein	gnl\|CDD\|223509	COG0432, COG0432, Uncharacterized conserved protein [Function unknown].	3.13969e-33
NZ_CP045929.1\|WP_154077545.1\|3623107_3626710_+\|cobaltochelatase-subunit-CobN	gnl\|CDD\|235663	PRK05989, cobN, cobaltochelatase subunit CobN; Reviewed.	0
NZ_CP045929.1\|WP_154077549.1\|3630682_3631999_-\|precorrin-methylase	gnl\|CDD\|235610	PRK05788, PRK05788, cobalt-precorrin 5A hydrolase.	4.17653e-44
NZ_CP045929.1\|WP_154077534.1\|3606319_3607171_+\|hypothetical-protein	gnl\|CDD\|183743	PRK12785, fliL, flagellar basal body-associated protein FliL; Reviewed.	0.00141961
NZ_CP045929.1\|WP_154077548.1\|3629010_3630078_-\|nickel-transporter	gnl\|CDD\|273277	TIGR00802, Hydrogenase_nickel_incorporation_protein_HupN, high-affinity nickel-transporter, HoxN/HupN/NixA family. This family is found in both Gram-negative and Gram-positive bacteria. The functionally characterized members of the family catalyze uptake of either Ni2+ or Co2+ in a proton motive force-dependent process. Topological analyses with the HoxN Ni2+ transporter of Ralstonia eutropha (Alcaligenes eutrophus) suggest that it possesses 8 TMSs with its N- and C-termini in the cytoplasm. [Transport and binding proteins, Cations and iron carrying compounds].	4.48575e-75
NZ_CP045929.1\|WP_154077544.1\|3620711_3621404_-\|precorrin-8X-methylmutase	gnl\|CDD\|181352	PRK08285, cobH, precorrin-8X methylmutase; Reviewed.	3.47329e-129
NZ_CP045929.1\|WP_154077542.1\|3618469_3619222_+\|cobalt-precorrin-6A-reductase	gnl\|CDD\|236144	PRK08057, PRK08057, cobalt-precorrin-6x reductase; Reviewed.	2.01964e-105
NZ_CP045929.1\|WP_154078923.1\|3609338_3610610_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	9.26025e-92
NZ_CP045929.1\|WP_154077547.1\|3627689_3628916_-\|uroporphyrinogen-III-C-methyltransferase	gnl\|CDD\|381169	cd11642, SUMT, Uroporphyrin-III C-methyltransferase (also known as S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT). SUMT is an enzyme of the cobalamin and siroheme biosynthetic pathway. It catalyzes the first of three steps leading to the formation of siroheme from uroporphyrinogen III; it transfers two methyl groups from S-adenosyl-L-methionine to the C-2 and C-7 atoms of uroporphyrinogen III to yield precorrin-2 via the intermediate formation of precorrin-1. Precorrin-2 is also a precursor for the biosynthesis of vitamin B12, coenzyme F430, siroheme and heme d1. This family includes proteins in which the SUMT domain is fused to other functional domains, such as to a uroporphyrinogen-III synthase domain to form bifunctional uroporphyrinogen-III methylase/uroporphyrinogen-III synthase, or to a dual function dehydrogenase-chelatase domain, as in the case of the multifunctional S-adenosyl-L-methionine (SAM)-dependent bismethyltransferase/dehydrogenase/ferrochelatase CysG, which catalyzes all three steps that transform uroporphyrinogen III into siroheme.	1.52083e-95
NZ_CP045929.1\|WP_154077536.1\|3610702_3611449_+\|peroxide-stress-protein-YaaA	gnl\|CDD\|234999	PRK02101, PRK02101, peroxide stress protein YaaA.	2.63237e-67
NZ_CP045929.1\|WP_154077532.1\|3604640_3605675_-\|aminotransferase	gnl\|CDD\|223594	COG0520, csdA, Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones].	2.37918e-31
NZ_CP045929.1\|WP_154077539.1\|3615144_3616371_+\|precorrin-6y-C5,15-methyltransferase-(decarboxylating)-subunit-CbiE	gnl\|CDD\|225151	COG2242, CobL, Precorrin-6B methylase 2 [Coenzyme metabolism].	2.36582e-69
NZ_CP045929.1\|WP_154078924.1\|3621400_3622642_-\|precorrin-3B-synthase	gnl\|CDD\|274131	TIGR02435, Precorrin-3B_synthase, precorrin-3B synthase. An iron-sulfur protein. An oxygen atom from dioxygen is incorporated into the macrocycle at C-20. In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC 1.14.13.83, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; EC 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5 and precorrin-6A, respectively. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin].	7.36793e-66
NZ_CP045929.1\|WP_154077540.1\|3616367_3617141_+\|precorrin-4-C(11)-methyltransferase	gnl\|CDD\|225430	COG2875, CobM, Precorrin-4 methylase [Coenzyme metabolism].	3.57253e-119
NZ_CP045929.1\|WP_154077537.1\|3611673_3612714_-\|TerC/Alx-family-metal-homeostasis-membrane-protein	gnl\|CDD\|274743	TIGR03718, R_switched_Alx, integral membrane protein, TerC family. Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family often are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains TerC itself from Alcaligenes sp. plasmid IncHI2 pMER610 and from Proteus mirabilis. It also contains the alkaline-inducible E. coli protein Alx, which unlike the two TerC examples is preceded by a yybP-ykoY leader.	1.6402e-119
NZ_CP045929.1\|WP_154077538.1\|3613527_3615042_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	3.8062e-130
NZ_CP045929.1\|WP_154077543.1\|3619209_3620715_-\|precorrin-2-C(20)-methyltransferase	gnl\|CDD\|381173	cd11646, Precorrin_3B_C17_MT, Precorrin-3B C(17)-methyltransferase (also named CobJ or CbiH). Precorrin-3B C(17)-methyltransferase participates in the pathway toward the biosynthesis of cobalamin (vitamin B12). There are two distinct cobalamin biosynthetic pathways. The aerobic pathway requires oxygen, and cobalt is inserted late in the pathway; the anaerobic pathway does not require oxygen, and cobalt insertion is the first committed step towards cobalamin synthesis. This model includes CobJ of the aerobic pathway and CbiH of the anaerobic pathway, both as stand-alone enzymes and when CobJ or CbiH form part of bifunctional enzymes, such as in Mycobacterium tuberculosis CobIJ where CobJ fuses with a precorrin-2 C(20)-methyltransferase domain, or Bacillus megaterium CbiH60, where CbiH is fused to a nitrite and sulfite reductase-like domain. In the aerobic pathway, once CobG has generated precorrin-3b, CobJ catalyzes the methylation of precorrin-3b at C-17 to form precorrin-4 (the extruded methylated C-20 fragment is left attached as an acyl group at C-1). In the corresponding anaerobic pathway, CbiH carries out this ring contraction, using cobalt-precorrin-3b as a substrate to generate a tetramethylated delta-lactone.	3.73383e-112
NZ_CP045929.1\|WP_154077535.1\|3607376_3609113_-\|proline--tRNA-ligase	gnl\|CDD\|236405	PRK09194, PRK09194, prolyl-tRNA synthetase; Provisional.	0
NZ_CP045929.1\|WP_154077546.1\|3626758_3627646_-\|class-A-beta-lactamase	gnl\|CDD\|185339	PRK15442, PRK15442, beta-lactamase TEM; Provisional.	1.08225e-55
NZ_CP045929.1\|WP_154077541.1\|3617330_3618419_-\|cobalt-precorrin-5B-(C(1))-methyltransferase	gnl\|CDD\|234615	PRK00075, cbiD, cobalt-precorrin-6A synthase; Reviewed.	6.02984e-150

>NZ_CP045929.1|WP_154077540.1|3616367_3617141_+|precorrin-4-C(11)-methyltransferase
MTVRFVGAGPGAADLITVRGRDTIAASSVCLYAGSLVPAELLAQAPNGAALVNTAKLTLDEIIDEMVTAHERGDDVVRLHSGDPSVFSAVAEQMRRLDAAGVPYEVVPGVPAFAAAAAVLRRELTVPGVGQTVVLTRTSSNATPMPEGEDLATLGQSGATMVLHLAVNLVEKVVEQLVPNYGSDCPVAVIAGASREDETVLRGTLADIGEQVRSAEITRTAVIVVGEVLTAGEFPDSHLYSHDRCRDTHVPDTPGTH
>NZ_CP045929.1|WP_154077539.1|3615144_3616371_+|precorrin-6y-C5,15-methyltransferase-(decarboxylating)-subunit-CbiE
MSAAAIDVVGIGADGWGGLSPRAHSVVHAADVVMGSSRQLELIPDTGARRVPWPSPLLPALPGLLDEYADARVCVLASGDPMFHGIGSTLARIVGADRLRVLPHASSVSLACARLGWPLHEVEVLSAVGKPVAALHPSVHDGYRILVLSADETTPAAVASLLVARGYGGSRMSVLDRLGDATESVTTRTAREWGSHEATALNVIAVECRADAEARVLARTPGLPDDAFDHDGQLTKRTVRAVTLSTLEPVPGALLWDVGAGAGSIAIEWMRTHPSCSATAIEHREDRAARITRNAQELGVPGLQVVTGAAPDALHGLDRPDAVFVGGGVTTEGLFGSCWQALRPGGRIVINAVTVESEAVLAELRARYGGELYRLAVDHARSVGGFTGWERQMPVTQWTVRKSHEEGT
>NZ_CP045929.1|WP_154077538.1|3613527_3615042_+|DEAD/DEAH-box-helicase
MFVPRPTPHRRPRRRRSAAPAPAPSLFDQAAVTAVDPAPFAELGLPKRLVRALADAGLTEAFPIQAATIPDALGGRDVLGRGQTGSGKTLAFGLPMLALLDGRSAEPQRPRGLVLVPTRELATQVTDALKPLAKALGLYVREIVGGMPFHRQADTLRRGVDLVVATPGRLNDHIQQGTCSLAEVQITALDEADQMADMGFLPQVRGLLDHVPSDGRRLLFSATLDGDVDKLVREYMTEPVVHSLAPPAASVDTMEHHQLSVSAETKNDVLAHIASRPGRTIMFVRTKHQADRLSRKLRKAGAPAEALHGGKTQNARNRILDEFRSGDSGTLIATNVAARGIHVDDVSLVVHVEPPADPKDYLHRAGRTARAGASGTVVTLVTDDQQPAFRQMTAKAGVDPVATEVAAGDEALTRLTGARPPSGVPIVTPSGQKQQSRSGARPTRNRGERSRGESGRSEGRSGERNKRRDGQAGDRTRAHNTNGRGNAGRSGGNRNARKGFARRG
>NZ_CP045929.1|WP_154077537.1|3611673_3612714_-|TerC/Alx-family-metal-homeostasis-membrane-protein
MFEEARVVHTVAQAESGSIGSLPLWLISIAVLVLLLVVDFIVTRKPHEVSLREAIGWSVFYLALPCVFAVWLWGQFGGGQALEFMTGFVVEKSLSVDNLFVFMLLLAAFAVPAALQQRVLLYGIVGALVLRGFFIAAGAALLQAGTWAFLVFGAILFFTAVKIFRDAVSGESFAPEVSEMRSVKFLRRLMPVTDDYRGAKLTVIENGKRALTPLTVVVVAVFATDVVFAVDSVPAVYGITEDPYLVFTTNAFALLGLRALYFVLHTALDKLVHLNHGLAIILGFIGVKLVLHWAHGIWPAVPEVPTPLSLAVIVLVLGVVTFTSLRATRKTPETESGDEHAHRHTH
>NZ_CP045929.1|WP_154077536.1|3610702_3611449_+|peroxide-stress-protein-YaaA
MLVLLPPSETKANGGDGPPLDLSALAHPDLTETRRAVVSALVDLADDVPSSLRLLGLSERRTDEVERNAALLGSPTMPGLLRYTGVLYDALDVGSLTESERARADERLAVGSALFGLVRGTDRIPAYRLSAGNSLPNLGTLRGVWRPVLEPLLSAREDLVVDLRSGAYTALARVPEALTVRVLTETQDGQRSVVSHHNKAHKGELARALARVPQEPRDVEDVITVAKDSGLRVERESEHQLCIVVPAA
>NZ_CP045929.1|WP_154078923.1|3609338_3610610_+|cytochrome-P450
MGANALSEAALRFRLVANNAATWSAAVSGDPTARLLHSPWRESPYPIYERLRSSGPLVRSKLGLVTATTHETCRAVLRDRSMGVRPESGPDPLGELDELDLSLLKLDPPDHTRLRKLAAPAFRARRLAALRESVESIAHDLVDRATRRGEFDLMRDVALPLPIRVITALLDLRDVDTPTLARHGSALASSLDGVRGPRQLRAVRRADAAFHAMFTDLMEQRRRAPGDDVVSDLVHAHDDEQVTADELVALCRLLLVAGFETTVNLIGNGTLALLRHPEQWAALRDDPGLAPSAVEEVLRWDGPVQSSARIAHETVEIGGRRLRKGTLVLVLLGSAGRDPAAHSDPDRFDITREESEHLAFSHGAHYCLGAPLARMEGDLAFRVLADWLPNLTLAGRPRQRRTTVLRGLRTLPVASGAVPAPRA
>NZ_CP045929.1|WP_154077535.1|3607376_3609113_-|proline--tRNA-ligase
MITRMSTLFLRTLREDPADAEVPSHKLLVRAGYVRRVGPGVYSWLPLGLAVFRRVEQVVREEMNAIGAQEILFPALLPREPYEATNRWAEYGPALFRIKDRKGADYLLGPTHEELFTLTVKGEYASYKDYPVMLYQIQTKYRDEERPRAGILRGREFVMKDSYSFDLDDDGLADSYRKHRDAYRTIFDRVGLRYVIVAATSGAMGGSASEEFLAESETGEDTYVRSTGSDYAANVEAVVTRAPEAQSVDDKPAAEVHHTPDTPTIETLVDFLNSTGERKFTAAETLKNVLVKTRQPGSDEWSLLAVAVPGDREVDFKRVEAALEPAQVELLTEADFAANPFLVKGYIGPKALQDNKVPFLVDPRIVTGTAWVTGADKPDHHVVDLVCGRDFTPDGTIEAAEVLEGDPSPDGTGTLESARGIEVGHIFQLGRKYSDTFGLDALGQDGKPKRITMGSYGVGVSRLVAAIVEQNHDRDGLVWPREVAPADVHMVMAGKDDTVRDTAERLAAELDDAGVRVILDDRASSPGVKFADAELVGVPTILVVGKGLANGVVEVKDRRSGERTEVAVDEIVDHLRAL
>NZ_CP045929.1|WP_154077534.1|3606319_3607171_+|hypothetical-protein
MTWPNNGQNNWGHQPPPQSGHQYTGNYSGFGMFEEPLRDGRKPRRRKWLTITAVVVAVLALAGGVAAALVFGGTTPQRPAPQAAPPPAPTSTTFVPPDAPEPVVPGWQVAYNPLGQIAYDVPPDWQVLPENDTWSAPTLGNVVFQGLSNGAPYSCGGGFVRGQVGSTAVEQAQPIDVTANQFADAVGREIYRTTSPQMQLQLAPPQPLQIDGVEAVRVDATATLPPGNPCLPTEATISTVVFQAKESFVVVVAGADSAGGPPEPAAPGAEVVGQIVESARPVR
>NZ_CP045929.1|WP_154077533.1|3605824_3606235_+|YjbQ-family-protein
METEELEVRTGSAEVVQDLNGECQRFLRQVGASDGLLHVWVPHATAGLAVLETGAGSDHDLLAALKDLFPEDDRWQHRHGSPGHGRDHVIPAVVAPYASIPVLGGSMALGTWQSVCLVDTNSDNPVRTVRLSFLAG
>NZ_CP045929.1|WP_154077532.1|3604640_3605675_-|aminotransferase
MREAFGATFDVPEGYLDTASIGIPPTVTADAMTETVRRWGSGLDGAGDFVDAADTARAAFGSLIGVPADRVAAGATVSQLVGLVAASLPADTTVLAAAQEFPSVTFPFAVQQRRGVRLTEVGLGELPARVAEHDLVVASVVQANNGRIVDLDALRVAAQAGGTRVLLDVTQAAGWLPLQLEWADFVVGTAYKWLLSPRGSAWMALRPDARALVAPLCANWYSVPDRDAATEGLPARIAEGAHGLDLSPSWFAHVGAATSMSWLLKVDRESVRRHCVGLVDVLREELGQSPAGSAITAVDVPEAHEKLAAAGIAHSVRAGAVRLAFHMYNTVDDVERVMRVLRSA
>NZ_CP045929.1|WP_154077541.1|3617330_3618419_-|cobalt-precorrin-5B-(C(1))-methyltransferase
MTDDERAPGGMRYGWTTGACATAATAAAYTALLTGTFPDPVRIVLPKGQRPAFALTREWLGDGQASAAVTKDAGDDPDVTHGAVVSVTVRPGQPGDGVVFHAGAGVGTITKPGLPLQVGEPAVNPVPRTMMRDVVAEIAAERGAGGDLDLEVSIEDGDELARHTWNPRLGIVGGLSVLGTTGIVVPYSCSAWIDSIRRGIDVARAEGLTHVAGCTGSTSERTVLDEYGLPMEAMLDMGDFAGAVLKYLRRHPVPRLTVAGGIGKMSKLADGHMDLHSKRSQVNFATLARIVREAGGSEALAARVAEANTALDALQVCQADGVPLGDLVARGARDVALDVLRAAPVDVDTLVIDRSGTIVGRT
>NZ_CP045929.1|WP_154077542.1|3618469_3619222_+|cobalt-precorrin-6A-reductase
MPPRILVLGGTGEARALASELTDRDEAQVTSSLAGRVRDPRLPDGHVRIGGFGGADGLAAYLAEDNTTAVVDATHPFAEGITANAFAACRTVGVPMLALRRPGWTEQSGDRWYRVDSLTAAAATLPAFGDRVFLSTGRLGLSSFGHLDQWFLVRTIDQPDPPMPRRSTVVLARGPFSVDDELALLREHRIDVLVTKDSGGSMTAAKLEAARTLGIPVIVVQRPPVPDVPTVSTVEDAVLWVETARTDHDG
>NZ_CP045929.1|WP_154077543.1|3619209_3620715_-|precorrin-2-C(20)-methyltransferase
MTGTLYGVGLGPGDPELLTVKAVRLIENAEVVAYHSARHGRSIARSIAEGHLRHGQIEEPLVYPVTTETTQHPGGYQGAIDEFYADAAERLAAHLEAGRDVVVLAEGDPLFYGSYMHMHKRLADRFPAEVVPGVTSVSAASAVLGRPLAERDEVLTVLPGTLEPDVLADHLARTDAAAVMKLGRTFGGVREAFEKAGALDRAWFVERATTDRQRWEPLAEVDPDAVPYFSLALLPSPVNNVRTPAAREPEESVVRQGEVVVVGLGPAGREWTTPQAQAAVTEADDLVGYGPYLDRLPSNPRQRKHASDNRVESERAEFALELARRGAKVAVVSSGDPGVFAMASAVVEVAAEKGDVPVRVLPGVTAAQAVASRIGAPLGHDYCVLSLSDRLKSWEVIADRLRAAAKADLAMALYNPASKTRTWQVESARQVLLEHRAPETPVVIGRDVGGAEESVRVVRLADLDPSEVDMRCLLLVGSSQTTLVDDADGRASVFSPRRYPS
>NZ_CP045929.1|WP_154077544.1|3620711_3621404_-|precorrin-8X-methylmutase
MTEQQQAPHDGVEHTRAPETVRADDYIRNGPEIYRHSFATIRSEARLDTLPTDIAQVAVRMIHACGMVDLVDDIAYSDGVVQQARTALRAGAPILCDAEMVAAGVTRKRLPADNEVLCSLSEPQVPKLAERLDTTRSAAALDLWGDRLDGAVVAVGNAPTALFRLLELLQAGAPRPAAVLGIPVGFVGAVESKQALVHHRSGVPFLVVHGRRGGSAMAVAALNAIASEEE
>NZ_CP045929.1|WP_154078924.1|3621400_3622642_-|precorrin-3B-synthase
MNKPGPPRTREDACPGAWHVHAAADGGLARIRLPGGRITAGQMRFLAESASELGNGQLELTSRANLQLRGVDDSDVAELATRLGSHGLLPSRSHETCRNVIASPCTGLDDDGLLDVSRCVEELDTALCAVPELAALPGRFLFTVDDGRGDVSTLGGDIGLHAVGATEFAVLLAGRDSGVRVGQESAARSAITAAEAFMRQRAAEPAPVWRLAELYDGRRRIAADLGRPCSEPSDPPFTEPVRPGIAARRGNLVALAVGAPLGRLTPQRASQLAALADRAGGDLRITPWRSVLVPGLAAAEAATRAQHLREQGFVVEADSPWSGMTACTGTPGCAKSHADVQRDAHRVAESLEPGGTPVHWVGCSRRCGTPRATAVEVLATGAGYDVRLADEVTASGLDAEDTPAAINAARRTA
>NZ_CP045929.1|WP_154077545.1|3623107_3626710_+|cobaltochelatase-subunit-CobN
MILLLSTSDTDLLSARASGADFRLANPARLGVEDLPELVDGTDLVVVRLLGGRRAWEEGLDWLLAGPRPVIVLGGEQAPDAMLMEHSTVPGGVAAEAHRYLAEGGPQNLEQLFGFLSDTVLLTGHGFDPPVALPTWGVLERTPRRTEGPTVALLYYRAHHVAGNTAFAHALCEAIEDKGGQALPVFCASLRTPEPDMIEELRKADSLVVTVLAAGGSKPATAQAGEDDEAWDIGALADLDIPILQGLCLTSSRAQWEDNDEGLSPLDAATQVAVPEFDGRLITVPFSFKENDEQGLPQYVADAERASRVAGIAVRHGRLRHVPAGERKIALMLSAYPTKHARIGNAVGLDTPASAVKLLRDMHAEGYDVGGITGDDALPGIEAQDGDELVHALIAAGGQDREWLTEEQLSGNPVRIAASAYRSWYETLPAELREEIERHWGPPPGELFVDHSRNPDGEIVLAALRAGNVVLMVQPPRGFGENPIAIYHDPDLPPSHHYLAAYRWLADEFDADAMVHLGKHGNLEWLPGKTAGLSAACGPDAALGDLPLVYPFLVNDPGEGTQAKRRVHATLVDHLVPPMARAESYGDIARLEQLLDEYANISAMDPAKLPAIRAQIWTLIQAAKLDHDLGMEERPHDAEFDDFLMHVDGWLCEVKDAQIRDGLHILGDPPAGEARVSLVLAMLRARQMWGGNTAALPGLREALGMAEDGSAGRTEVDEQEGRAYALVEAMEQASWEPDSASRVCTDVLGDAPSTVVEVLRFAATEIVPRLDATTDETRSTLRALDGRFIPAGPSGSPLRGLVNVLPTGRNFYSVDPKAIPSRLAWETGQAMADSLVERYKSDTGEWPRSVGLSVWGTSAMRTAGDDIAEVLALIGVRPTWDEASRRVNGLEVVGLEELGRPRIDVTVRISGFFRDAFPHVVAMLDDAVQLVAKLDEPGEQNFLRAHTDADLAEHGDHRRATMRIFGSKPGAYGAGLLSLIDSRNWRDDADLAEVYAVWGGFAYGRGLDGAPARGDMESAYRRISVAAKNTDTREHDIADSDDYFQYHGGMVATVRALTGKSPAAYIGDSTRPDSVKTRSLHEETSRVFRARVVNPRWLSAMRKHGYKGAFELAATVDYLFGYDATTGVVGDWMYEKLAETYVMDPENHKFLTESNPWALHGIAERLLEAADRQMWAAPNPETLQALREAYLETEGDLEDR
>NZ_CP045929.1|WP_154077546.1|3626758_3627646_-|class-A-beta-lactamase
MRRTTVKSISRRGVLAGLAAVPVLASTRHAIAGSEPTFPELEQRYGARLGVWARNAVTGRTVHHRPHERFAMTSTFKPYAAAALLREHGLAGDYFRHRVFFRREDLVVHSPICEQAVDTGMTVLELCDAAITYSDNTAGNLLLTELGGPAAIAPFARTLGDPATRLDRWEPELNEAERGDPRDTTTPAAIGTGYGRLVLADGLPRPERDRLTAWLLANTTGDTSIRAGVPPTWVTGDKTGGGSYATNNDVAVTWTDLDQPIIIAVLSDKPIRDAEPDDALIADAAKRVAERLTDA
>NZ_CP045929.1|WP_154077547.1|3627689_3628916_-|uroporphyrinogen-III-C-methyltransferase
MSTHDERHYFAGLDLGGKHVAVVGGGTVAQRRVPRLINAGARVEVVSPEVTPAVEAMADAGELTWSARRYTPGDLDETWYAIACTSDPDVNARVVADAESRRIFCVRADDASQGTAVTPAIAEHDGLLLGVLAGGAHRRSSVVRDGLVEALRSGVVDDRPQRHEPGVALVGGGPGAPDLITVRGRQLLARADVVVTDRLAPRELLDDLGPHVEVVDASKIPYGRAAHQDAINELLVGRARAGKFVVRLKGGDPYVFGRGYEELIACVEAGVDVTTVPGVTSAFAAPAAAGVPVTHRRVTHEVVVVSGHVGPDDEQSLVDWEALGKLRGTIVLMMAVKNIGEFARVLVQHGRARETPVAVVQDGATQGQHTLRSTLDQVAADVREAGIRPPAVIVVGPVTTLDPRLTDA
>NZ_CP045929.1|WP_154077548.1|3629010_3630078_-|nickel-transporter
MATETSIPDTPASGGWGRVERRNAALVLGAVGMLHLVGWGMYLAAQDSFTAAGGLAAAGMTAYLLGVRHGFDADHVAVIDDATRLLMQRGKKPVATGMWFALGHAGVVVALAMAVAFVAGPAAQRWAEQVGGRVGLWVSLFVVAVLAVLAVLNALVLRDAVRLLRRARAGEVGDSEVELVLGRRGLLARLLRGRMSLVGQSWHLLVIGFLFGLGMQTATEVTVLALVAPGELSAMAVLSLPLLFAAGMCTVDSIDGMLMSRAYTWSLARPLRRLWVNVTTTTLTVVLAAVVALVVLAGVFDELGAAGLAPVAAIGDHFELLGYLTLAAFMAVWGGAALWWRFSGADRRTAGAPSR
>NZ_CP045929.1|WP_154077549.1|3630682_3631999_-|precorrin-methylase
MIGLFAPTHTGRRRASELAARFGADALVVEGPVGPSLRRVWDRLSGVVLFLGTGSAVRSVAPLLTGERTDPAVVCVDADGRFAVVLSGAGGNALALQVADVLDAVAVTVEQEHVTGPLDELVDALDATVDGDVTECSAAVADGEPVGLSNPHGFPLPALPDTVSPDAASPQWTIALDDRRPADADRARLLWLVPRTLIVGVGASREASRTEIVEAVALLEREYSLDPRAVRAIATVARAEDHPGLAEAVQDLGFWHSEEGGDELPLRVFPADVLDRVDVPSPSGAVRDRVGTGSVAEAAALAAATEDAAGGPVDLVVPKLTSRRVTVAAARLRPRGRLAVVGVGPGPDDLRTPRADAELRRAAVVVGSRAVLDRVGRVLSPDARTEVGVVADAVDVAASGRAVAFAHTGEVEQVDAERAAVEVVVVPGVSRGVTGPVD

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Crispr_ID: NZ_CP045929_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045929_8

3802159-3802291

Orphan

Consensus_repeat	Method
GGGTCGGCAGGCAAGGATTGATCAGTCCCTCCTGAGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP045929_8

>merge|NZ_CP045929|8|3802159-3802291|CRISPRCasFinder
GGGTCGGCAGGCAAGGATTGATCAGTCCCTCCTGAGGCACATGACCGCGGCGCGCAACGCCTCCATGGGGGGCGGTGGTCGGGCGACGGGCGGGCGGGTCGGCAGGCAAGGATTGATCAGTCCCTCCTGAGGC

>NZ_CP045929|8|8|3802159-3802291|CRISPRCasFinder
GGGTCGGCAGGCAAGGATTGATCAGTCCCTCCTGAGGC	ACATGACCGCGGCGCGCAACGCCTCCATGGGGGGCGGTGGTCGGGCGACGGGCGGGC
GGGTCGGCAGGCAAGGATTGATCAGTCCCTCCTGAGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045929.1\|WP_154077678.1\|3792578_3793574_-\|ketol-acid-reductoisomerase	unknown	unknown	gnl\|CDD\|235491
NZ_CP045929.1\|WP_154077680.1\|3794184_3796017_-\|acetolactate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|236098
NZ_CP045929.1\|WP_154077691.1\|3810046_3810538_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP045929.1\|WP_154077689.1\|3808679_3809366_+\|amino-acid-binding-protein	unknown	unknown	gnl\|CDD\|153159
NZ_CP045929.1\|WP_154077686.1\|3806282_3806477_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045929.1\|WP_154077688.1\|3807987_3808287_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	unknown	unknown	gnl\|CDD\|178810
NZ_CP045929.1\|WP_154077692.1\|3810573_3812760_-\|NAD-dependent-DNA-ligase-LigA	unknown	unknown	gnl\|CDD\|236137
NZ_CP045929.1\|WP_154077679.1\|3793670_3794177_-\|acetolactate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|183365
NZ_CP045929.1\|WP_154077684.1\|3799996_3800944_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP045929.1\|WP_154077687.1\|3806473_3807988_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	unknown	unknown	gnl\|CDD\|234572
NZ_CP045929.1\|WP_154076931.1\|3802675_3803473_-\|IS5-family-transposase	unknown	unknown	gnl\|CDD\|379129
NZ_CP045929.1\|WP_154077683.1\|3799150_3799885_-\|DoxX-family-membrane-protein	unknown	unknown	gnl\|CDD\|225168
NZ_CP045929.1\|WP_154077685.1\|3804780_3806286_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	unknown	unknown	gnl\|CDD\|235489
NZ_CP045929.1\|WP_154077676.1\|3790048_3791644_-\|phosphoglycerate-dehydrogenase	unknown	unknown	gnl\|CDD\|237436
NZ_CP045929.1\|WP_154077677.1\|3792211_3792448_-\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
NZ_CP045929.1\|WP_154077690.1\|3809803_3810019_-\|type-II-toxin-antitoxin-system-VapB-family-antitoxin	unknown	unknown	gnl\|CDD\|227737
NZ_CP045929.1\|WP_154077682.1\|3797240_3799085_+\|dihydroxy-acid-dehydratase	unknown	unknown	gnl\|CDD\|237104
NZ_CP045929.1\|WP_154077681.1\|3796316_3797033_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371225
NZ_CP045929.1\|WP_154078943.1\|3809402_3809807_-\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350323
NZ_CP045929.1\|WP_154077675.1\|3788749_3789790_-\|3-isopropylmalate-dehydrogenase	unknown	unknown	gnl\|CDD\|179579

Protein	Function_ID	Function_description	E-value
NZ_CP045929.1\|WP_154077678.1\|3792578_3793574_-\|ketol-acid-reductoisomerase	gnl\|CDD\|235491	PRK05479, PRK05479, ketol-acid reductoisomerase; Provisional.	0
NZ_CP045929.1\|WP_154077680.1\|3794184_3796017_-\|acetolactate-synthase-large-subunit	gnl\|CDD\|236098	PRK07789, PRK07789, acetolactate synthase 1 catalytic subunit; Validated.	0
NZ_CP045929.1\|WP_154077689.1\|3808679_3809366_+\|amino-acid-binding-protein	gnl\|CDD\|153159	cd04887, ACT_MalLac-Enz, ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains. The ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI, a malolactic enzyme (MalLac-Enz) which converts malate to lactate, and other related ACT domains. The yqkJ product is predicted to convert malate directly to lactate, as opposed to related malic enzymes that convert malate to pyruvate. Members of this CD belong to the superfamily of ACT regulatory domains.	1.04135e-16
NZ_CP045929.1\|WP_154077688.1\|3807987_3808287_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	gnl\|CDD\|178810	PRK00034, gatC, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC.	4.78854e-36
NZ_CP045929.1\|WP_154077691.1\|3810046_3810538_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.74563e-14
NZ_CP045929.1\|WP_154077692.1\|3810573_3812760_-\|NAD-dependent-DNA-ligase-LigA	gnl\|CDD\|236137	PRK07956, ligA, NAD-dependent DNA ligase LigA; Validated.	0
NZ_CP045929.1\|WP_154077679.1\|3793670_3794177_-\|acetolactate-synthase-small-subunit	gnl\|CDD\|183365	PRK11895, ilvH, acetolactate synthase 3 regulatory subunit; Reviewed.	6.88119e-94
NZ_CP045929.1\|WP_154077684.1\|3799996_3800944_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.28801e-16
NZ_CP045929.1\|WP_154077687.1\|3806473_3807988_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	gnl\|CDD\|234572	PRK00012, gatA, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA.	0
NZ_CP045929.1\|WP_154076931.1\|3802675_3803473_-\|IS5-family-transposase	gnl\|CDD\|379129	pfam13340, DUF4096, Putative transposase of IS4/5 family (DUF4096).	1.5349e-24
NZ_CP045929.1\|WP_154077683.1\|3799150_3799885_-\|DoxX-family-membrane-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	3.18867e-19
NZ_CP045929.1\|WP_154077685.1\|3804780_3806286_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	gnl\|CDD\|235489	PRK05477, gatB, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB.	0
NZ_CP045929.1\|WP_154077676.1\|3790048_3791644_-\|phosphoglycerate-dehydrogenase	gnl\|CDD\|237436	PRK13581, PRK13581, D-3-phosphoglycerate dehydrogenase; Provisional.	0
NZ_CP045929.1\|WP_154077677.1\|3792211_3792448_-\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	5.17638e-14
NZ_CP045929.1\|WP_154077690.1\|3809803_3810019_-\|type-II-toxin-antitoxin-system-VapB-family-antitoxin	gnl\|CDD\|227737	COG5450, COG5450, Transcription regulator of the Arc/MetJ class [Transcription].	1.24387e-09
NZ_CP045929.1\|WP_154077682.1\|3797240_3799085_+\|dihydroxy-acid-dehydratase	gnl\|CDD\|237104	PRK12448, PRK12448, dihydroxy-acid dehydratase; Provisional.	0
NZ_CP045929.1\|WP_154077681.1\|3796316_3797033_+\|hypothetical-protein	gnl\|CDD\|371225	pfam10756, bPH_6, Bacterial PH domain. This domain has a bacterial type PH domain structure. This domain was previously known as DUF2581. This family is conserved in the Actinomycetales. Although several members are annotated as RbiX homologs, RbiX being a putative regulator of riboflavin biosynthesis, the function could not be confirmed.	3.55541e-12
NZ_CP045929.1\|WP_154078943.1\|3809402_3809807_-\|PIN-domain-containing-protein	gnl\|CDD\|350323	cd18756, PIN_MtVapC15-VapC11-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC11, VapC15, and related proteins. This subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC11 and VapC15 toxins. M. tuberculosis VapC11 and VapC15 cleave tRNA3 Leu-CAG, VapC11 may additionally cleave tRNA13Leu-GAG and tRNA10Gln-CTG. This subgroup belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is a PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	3.75681e-44
NZ_CP045929.1\|WP_154077675.1\|3788749_3789790_-\|3-isopropylmalate-dehydrogenase	gnl\|CDD\|179579	PRK03437, PRK03437, 3-isopropylmalate dehydrogenase; Provisional.	0

>NZ_CP045929.1|WP_154077684.1|3799996_3800944_+|alpha/beta-fold-hydrolase
MGVESVTEFDVVAGDGTSVRAWEHRDDTAEPSTVLWCPGLGATPEAWPDLLESGAVSHVVSWYHRGTFGSARPAVPSRITLAEHVDDALAVLDRAGVARCTVVGWSVGVGVAAELARRRPDRVSGLLLIAGTPGAGFEAMFGTLGVPAPLRPLLASTGAMSLRLLGPALDSVLHRMPATELSARLLQHSGFMRPGADPERVTAAMRRFLRHDWGWYFTLALATGLAAAVPLNAVRCPITLVVGRHDLLSDTPRAVASVAGLAQARVRIFDTSHFVPLEAPAELRDELTLLLRREFAVDCARLGLVPEDLPALETD
>NZ_CP045929.1|WP_154077683.1|3799150_3799885_-|DoxX-family-membrane-protein
MSTHDDPPGGAGGYPDDRTVQNAPAGARSGRQQAVSAQTTQIRTGGAGSYDSVDADYTDADPGVYDDRRGLDFYDDVDRGARWHGGADLGLLVLRLALGVIFGLHGAQKLFGVLGGPGTEGFAESLTTMGFEQTAILSLVTGAAELGGGALLVLGLFTPLGAAGLAGVMGPAIALNAQSGFFASDGGVEFEVLLLCAAVALMFTGPGRVSLDNGRAWYRRPLVSGFLALLLAAGSAAAVFFLLR
>NZ_CP045929.1|WP_154077682.1|3797240_3799085_+|dihydroxy-acid-dehydratase
MPPLRSRTTTHGRNAAGARSLWRATGMTDSDFGKPIVAIANSYTQFVPGHVHLRDLGDVVAGTVREAGGVPREFHTIAVDDGIAMGHSGMLYSLPSREIIADSVEYMVNAHQADALVCISNCDKITPGMLNAAMRLNVPTVFVSGGPMEAGKAVVVDGVAQAPTDLITTIAASANSAVDDEGLGEVERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATHALRRELFENAGRTVVEIAQRWYRDDDASVLPRSVASRKAFENAMALDMAMGGSTNTVLHVLAAAQEGEVDFTLEDIERISRAVPCLSKVAPNSDYHMEDVHRAGGITALLGELDRASLLHRDVSSVHSPDLAGWLSEWDIRGESPSTRAIELFHAAPGGVRTTQAFSTENRWSSLDTDSEGGCIRSVPHAYTADGGLAVLRGNLAEDGAVVKTAGVEEELWTFEGPARVLGSQEQAVSAILNREIRPGDVLVIRYEGPAGGPGMQEMLHPTAFLKGSGLGKQCALITDGRFSGGSSGLSIGHISPEAAHGGAIGLVQDGDRIRIDVPSRELELLVDDEVLTERRSKMDAAEHPWRAADRERPVTTALRAYARLATSASYGAVRDLGT
>NZ_CP045929.1|WP_154077681.1|3796316_3797033_+|hypothetical-protein
MSQSAADPENTHAADEVPHLQDRTVGESSTDHAETTVLTESAGTGHDSASEESSGADAPENTPGEAASEEAELDGAASDGAAGSGDAEATAAPAAATAIGNKATAEYETAVRRLPDKLTFRITGASLIAVIIVTVCMSPLALSSWWLALLFLVPIGMAVWVLRVRTVVTPESVAACSLTRTTTVRWDDVKSLRLDERRWVRLVLASGREVTLPAVRVRNLPNLAAMSGGRIADPGTEA
>NZ_CP045929.1|WP_154077680.1|3794184_3796017_-|acetolactate-synthase-large-subunit
MTSAKTRQNPVPAPPPGHRPKPAPPSGSPVKATGAQSLVRSLEAAGCEVVFGIPGGTILPAYDPLLDSSKVRHVLVRHEQGAGHAATGYAQATGKVGVCMATSGPGATNLVTALADAHMDSVPIVAITGQTARSMIGTDAFQEADICGITLPITKHNFLVTDPAEIPRVIAEAFYIASSGRPGPVLVDIPKDVQQVNTSFVWPPETKLPGYKPTSKPHGKQVREAAKLIGQSHRPVLYVGGGVLKADATEQLRELAEATGIPVVTTLMARGAFPDSHPQHLGMPGMHGKVGAVAAMQRSDLLIALGTRFDDRVTGQLSTFAPEAKVVHADIDPAEISKNRAADVPIVGDCKDIIGDLVEAVTAASEEHGRPDLAPWWEQLERWRSTFPLGYEWPSDGTLSPEYVIERLGALVGSDAVYTAGVGQHQMWAAQFISYEKPRTWLNSGGLGTMGYAVPAAMGAKAGMGETTVWAIDGDGCFQMTNQELATCAIEEIPIKVAVINNGNLGMVRQWQNLFYAERYSHSGLGTHKHRIPDFVMLAESLGCAGLRCESKEDVDSVIQRAMEINDRPVVIDFVVGEDAQVWPMVAAGTGNDEIMAARGIRPLFDEDEG
>NZ_CP045929.1|WP_154077679.1|3793670_3794177_-|acetolactate-synthase-small-subunit
MSRHTLSVLVENVPGVLSRVSGLFSRRSFNIESLAVGPTEHPEISRMTIVVSVSEQPLEQVTKQLNKLINVIKIVELEPESAVQRELLMVKVRADSSVRSQVLETVQLFRAKVVDVSPEALTIEATGDVDKLDALLRMLEPYGVREVVQSGTIAIGRGPRSITATAVR
>NZ_CP045929.1|WP_154077678.1|3792578_3793574_-|ketol-acid-reductoisomerase
MATEIFYDSDADLGIVQGRKVAIIGYGSQGHAHALSLRDSGVDVRIGLPESSKSRAKAEEEGLRVVTPSEASAEADVIMILAPDTKQRQIYADDIAPNLKSGDALFFGHGFNIRYGLIQPPSDVDVAMVAPKGPGHLVRRQFVDGKGVPCLIAVEQNPSGSAQQLALAYAAGIGGARAGVIKTTFTEETETDLFGEQAVLCGGASALVQTGFEVLVEAGYQPEIAYFEVLHELKLIVDLMWEGGIAGQRYSISDTAEYGDLTRGPRVIDEHVKESMRKILAEVQDGTFAKEWVGEDEAGRPNFQKLQDAGNAHQIEEVGKKLRGLMSWTQR
>NZ_CP045929.1|WP_154077677.1|3792211_3792448_-|DUF397-domain-containing-protein
MNEHIHDDKFHVRGRLDFTGAEWITSTEDDEPGVEIAFVDGYIGMRNGADPSGPLLVFTPEEWDAFVAGAKDGEFDEP
>NZ_CP045929.1|WP_154077676.1|3790048_3791644_-|phosphoglycerate-dehydrogenase
MTNASRPVVLIAEKLASSVLDALGDEVEIRHVDGTDRPALLDAVADADALLVRSATKVDAEVLAATTRLKVVARAGVGLDNVEVPAATERGVMVVNAPTSNIVSAAEHAMALLMAVARNVAPADASLRQGEWKRSAYGGVEINGKTVGVIGLGKIGQLFAARVEAFGANLIAYDPYVSAGRAAQLGIELVSLDELLERADMMSIHLPKTAETLGLIGAEQLKKVKQGAIVINAARGGLIDEEALADALRSGHLGGAGIDVYSTEPTTDSPLFELENVTATPHLGASTVEAQDRAGTDVADSVLLALRGDFVPDAVNVQGGAVGEEVRPFLPLTQKLGSMLAALLGSTPTSVSVEARGELADEDVAVLPLAAMRGLFSGAVDSQVTFVNAPQLADDLGVSVDVKRTSESPNHRSVVSVRASLPDGRSGVVSGTVSGPTEVEKLIEINGRHFDIRAEGSMLVFEYPDRPGVMGKVGTLLGEVGVNIEAAQLSQTTGGEDATMLLRVDRPVDGGVLEPIGAAVGARIVRNVDFG
>NZ_CP045929.1|WP_154077675.1|3788749_3789790_-|3-isopropylmalate-dehydrogenase
MRLAVIPGDGIGPEVVAEALKVLGEVSPDAEITRYDLGASRWHATGELLPESVLSELRQHDGILLGAVGDPTVPSGILERGLLLRLRFELDHHVNLRPAQLYPGVTSPISEPGEVDMVVVREGTEGPYVGNGGILRKDTAHEIATEVSLNTAFGVERVVKDAFARAESRPRKHLTLVHKTNVLTHAGSLWSRIVEEVSLQHPDVTVAYQHIDATTIHLVTDPGRFDVIVTDNLFGDIVTDLAGAITGGIGLAASGNIDATRRNPSMFEPVHGSAPDIAGQGAADPTAAVLSVALLLDHLGEHEASRRIEASVAFDLATRDHSAPGATTAVGDRLAALVSSREVAQA
>NZ_CP045929.1|WP_154076931.1|3802675_3803473_-|IS5-family-transposase
MTDAEWAVIEPLLPTAACASPAGGRPEKHHRRDIVDAIRYVTDNGVKWRALPVDFPPCKTVYGFFARWRENGTVEIMRDALREQVRQQAGRRPRPTAAAIDAQSVRAAETVGDSTRGYDAGKKVNGRKRHIAVDTMGLLLVVMVTAANLQDRPAGRPLLSLLHRAHHRVRHIWADGGYTGTLLTWAKTTLGITVEIVKKLAEQTGFVPLHRRWVVERTFAWISQARRNTRDYERLPEHSEAFINWAMITTMSRRLTRPQTRAPTP
>NZ_CP045929.1|WP_154077685.1|3804780_3806286_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB
MTAVADIMDYDEVLERYDPVLGLEVHVELSTRTKMFCGCANRFGAEPNTQVCPVCLGLPGALPVVNGTGVESAIRIGLALNCQVAEWCRFARKNYFYPDQPKNFQTSQYDEPIVFDGHLDVVLDDGETFRVEIERAHMEEDTGKSLHVGGATGRIHGAEHSLLDYNRAGVPLIEIVTKPIAGAGARAPEVARAYVTALRDLLRALDVSDVRMDQGSLRCDANVSLMPRGGTEFGTRTETKNVNSLRSVERAVRYEMCRHAAVLDGGGEIVQETRHFDEASATTSAGRRKETAEDYRYFPEPDLVPIAPSREWVEELRTTLPELPWERRKRVQQEWGLSDQELRDLVNAGALELIVATVDAGSSPDEARSWWVAYLAQQANLQGVELGELAITPKQVARVIALVSEGTLTNKLARQVVDGVLAGEGEPDEVVAARGLEVVSDDSALQAAIDEALAAQPDVADKIRDGKVQAAGAIVGAVMKATQGQADAKRVRELVLATCGQ
>NZ_CP045929.1|WP_154077686.1|3806282_3806477_-|hypothetical-protein
MNYKIKAAILIGSQVASVVGLQKKIKQAREDNDRLALADSIISGLGVITGLALAFRTLRRKEEL
>NZ_CP045929.1|WP_154077687.1|3806473_3807988_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA
MTDLTRLTAAELAETIRSGETSAEDVTQAHLDRIDAVDPVVHAFLHVGADEALEAARKVDADRAAGTEASALAGVPLALKDVFATSDMPTTVGSKMLEGWRPPYEATVTRKLREAGVVVLGKTNMDEFAMGSSTENSAYGPTRNPWDTTRIPGGSGGGSSASLAAFQAPLAIGTDTGGSIRQPGAVTGTVGVKPTYGGVSRYGLVAFSSSLDQGGPCARTVLDAALLHEVIGGRDPMDSTSIDAPVPPVVDAARHGANGDLNGVRIGVVREFAGEGYQPGVERSFQAAVRQLTDLGAEVVEVSCPNFDYALGAYYLIAPSEASSNLARFDAMRYGLRVGDDGSRSAEQVMSLTREAGFGAEVKRRIMLGTYALSSGYYDAYYGSAQKVRTLITRDFAAAFEQVDVLVSPTTPTTAFPIGERVDDPMAMYLNDLCTIPSNLAGNAAMSVPCGLSDEDGLPVGLQIMAPATADDRLYRVGAAYEAARDAADGGALINRVPHLEVAG
>NZ_CP045929.1|WP_154077688.1|3807987_3808287_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC
MSTISRDEVAHLAGLARLAVTEEELDTFAGQLDQILDAVAKVGEVASDDIPPTSHAVPVTNVFREDAVRPSLSREQALAGAPAAEENRFRVPRILDEEA
>NZ_CP045929.1|WP_154077689.1|3808679_3809366_+|amino-acid-binding-protein
MPCTKLEAWSPVSFLIRVQVPDRPGTLGAVASALGEIGADILSVDVVERGQDMAVDDMVVELSGNRLPDVLITAAESIDGVVVDAVRPYAGVLDTHRELELVEEIAAEPANGLQILAEGVPKIIRSGWAMVFGHRSGGAEQLAASQSAPQEGYLELPWLPLARATILDSDGHWVPETWQELATELAATPIGKPDRVLLAGRPGGPVFRKAEVARLAHLAGIVSVVLEG
>NZ_CP045929.1|WP_154078943.1|3809402_3809807_-|PIN-domain-containing-protein
MILVDTSVWIEWLRATGSTADKAVQELRGEPQLLATTPPVRMEVLAGVSPRRVAMVSDVLDSAVPLAVESYTDFDTAAELFRAARATGRTVRSLLDCVIAAVAIREQATLLHRDHDFVVLSEVAPGLVCHSTVE
>NZ_CP045929.1|WP_154077690.1|3809803_3810019_-|type-II-toxin-antitoxin-system-VapB-family-antitoxin
MTRTNIDIDDELIANVMDRYRLGSKREAVDFALRRVARPRLTTEALESLHGIGFDLDLEELRGGSRVIEWE
>NZ_CP045929.1|WP_154077691.1|3810046_3810538_-|GNAT-family-N-acetyltransferase
MQTRTIRRAQPEEFDAVGALTVRAYVEGGHLDGDEDYTEVLRDASARAEKATLLVAVEGDSVVGTATFAMHGSGWAEAARPGEAELRMLAVVPEHHGSGVGRALLEAVVAEARSYELDRIVLFSQESMTQAQAMYRRSGFYRRPEYDWRPLPEVRLLSFALDL
>NZ_CP045929.1|WP_154077692.1|3810573_3812760_-|NAD-dependent-DNA-ligase-LigA
MTSDDRATTADAPEDTAATSEDARPADPAANTDAEGVEDVPGEVRERYGNLVEEVRGHQFRYYVLDSPLITDGEFDELFVELQRVEDEHPALRTPDSPTQIVGGTFSTEFTAVDHLERMLSLDNAFDEDELRTWVDRVEREVGSAASYLCELKIDGLAINLLYRDGRLERALTRGDGRTGEDVTLNVRTMHDVPDLLTGTDEYPVPALVEVRGEVFFRVSEFGELNAALVDAGKAPFANPRNAAAGSLRQKDPRITRNRPLRLICHGLGRREGFEPARQSESYAALRAWGLPVSEHTRVLSATDAIVEHVRYWGEHRDDAEHEIDGVVVKVDEVSLQRRLGATSRTPRWSIAYKYPPEQATTALLDIQVNVGRTGRVTPFAVMEPVKVAGSTVSMATLHNSDEVRRKGVFIGDRVVIRKAGDVIPEVLGPVTDARDGSEREFVMPTECPECGSTLSRQKEGDVDIRCPNSRTCPAQLRERLFHLAGRGAFDIEVLGYEAAAALLASGVLVDEGDVFDLDEQKLLKAPLFRTKAGALSANGRKLLDNLESSKSKPLWRVLVALSIRHVGPTAAQALARELGSLERIEAAEEADLAAVDGVGPTIATAVREWFTVDWHREVVRKWREAGVRMEDERDQSVPRHLEGLSIVVTGSLQVYSRDEAKELIMARGGRAAGSVSKKTAFVVVGDAPGSKYDKAMQLKVPVLDEDGFTVLLDQGPEAAAQRALPAE

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Crispr_ID: NZ_CP045929_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045929_9

4310979-4311133

Orphan

Consensus_repeat	Method
GAGCGAACGGCACTTTCGCCTCACCAGACGAGGTGAGAGTGCCGTTCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP045929_9

>merge|NZ_CP045929|9|4310979-4311133|CRISPRCasFinder
GAGCGAACGGCACTTTCGCCTCACCAGACGAGGTGAGAGTGCCGTTCGTCTCACCACCGGATTCCGCGGACGCACCCCCTCCAGCACACCCAGCTACCCGTCCCAGCGAGCGAACGGCACTTTCGCCTCACCAGACGAGGTGAGAGTGCCGTTCG

>NZ_CP045929|9|9|4310979-4311133|CRISPRCasFinder
GAGCGAACGGCACTTTCGCCTCACCAGACGAGGTGAGAGTGCCGTTCG	TCTCACCACCGGATTCCGCGGACGCACCCCCTCCAGCACACCCAGCTACCCGTCCCAGC
GAGCGAACGGCACTTTCGCCTCACCAGACGAGGTGAGAGTGCCGTTCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045929.1\|WP_154078075.1\|4316145_4317048_+\|DUF559-domain-containing-protein	unknown	unknown	gnl\|CDD\|380141
NZ_CP045929.1\|WP_154078063.1\|4297445_4298777_-\|phosphoglucosamine-mutase	unknown	unknown	gnl\|CDD\|237672
NZ_CP045929.1\|WP_154078079.1\|4319895_4320501_-\|30S-ribosomal-protein-S4	unknown	unknown	gnl\|CDD\|235411
NZ_CP045929.1\|WP_154078062.1\|4296730_4296949_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045929.1\|WP_154078080.1\|4320524_4320929_-\|30S-ribosomal-protein-S11	unknown	unknown	gnl\|CDD\|180007
NZ_CP045929.1\|WP_154078074.1\|4315284_4316031_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045929.1\|WP_154078078.1\|4318655_4319747_-\|DNA-directed-RNA-polymerase-subunit-alpha	unknown	unknown	gnl\|CDD\|235359
NZ_CP045929.1\|WP_154078076.1\|4317144_4318026_-\|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl\|CDD\|234577
NZ_CP045929.1\|WP_154078073.1\|4313977_4315288_+\|type-VII-secretion-protein-EccE	unknown	unknown	gnl\|CDD\|274857
NZ_CP045929.1\|WP_154078064.1\|4299482_4299926_-\|50S-ribosomal-protein-L13	unknown	unknown	gnl\|CDD\|181703
NZ_CP045929.1\|WP_154078071.1\|4311135_4312023_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045929.1\|WP_154078065.1\|4300301_4300589_-\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|274862
NZ_CP045929.1\|WP_154078066.1\|4300649_4300958_-\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|274862
NZ_CP045929.1\|WP_154078077.1\|4318046_4318604_-\|50S-ribosomal-protein-L17	unknown	unknown	gnl\|CDD\|235522
NZ_CP045929.1\|WP_154078068.1\|4303660_4307749_-\|type-VII-secretion-protein-EccCa	unknown	unknown	gnl\|CDD\|274858
NZ_CP045929.1\|WP_154078072.1\|4312199_4313804_-\|type-VII-secretion-protein-EccB	unknown	unknown	gnl\|CDD\|368288
NZ_CP045929.1\|WP_154078069.1\|4308105_4309536_+\|type-VII-secretion-integral-membrane-protein-EccD	unknown	unknown	gnl\|CDD\|274855
NZ_CP045929.1\|WP_154078067.1\|4301503_4303348_-\|type-VII-secretion-associated-protein	unknown	unknown	gnl\|CDD\|212667
NZ_CP045929.1\|WP_154078070.1\|4309547_4310963_+\|type-VII-secretion-associated-serine-protease-mycosin	unknown	unknown	gnl\|CDD\|274856
NZ_CP045929.1\|WP_154079005.1\|4298913_4299309_-\|30S-ribosomal-protein-S9	unknown	unknown	gnl\|CDD\|178888

Protein	Function_ID	Function_description	E-value
NZ_CP045929.1\|WP_154078076.1\|4317144_4318026_-\|tRNA-pseudouridine(38-40)-synthase-TruA	gnl\|CDD\|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	1.15704e-101
NZ_CP045929.1\|WP_154078063.1\|4297445_4298777_-\|phosphoglucosamine-mutase	gnl\|CDD\|237672	PRK14318, glmM, phosphoglucosamine mutase; Provisional.	0
NZ_CP045929.1\|WP_154078079.1\|4319895_4320501_-\|30S-ribosomal-protein-S4	gnl\|CDD\|235411	PRK05327, rpsD, 30S ribosomal protein S4; Validated.	9.64031e-117
NZ_CP045929.1\|WP_154078080.1\|4320524_4320929_-\|30S-ribosomal-protein-S11	gnl\|CDD\|180007	PRK05309, PRK05309, 30S ribosomal protein S11; Validated.	2.42851e-85
NZ_CP045929.1\|WP_154078078.1\|4318655_4319747_-\|DNA-directed-RNA-polymerase-subunit-alpha	gnl\|CDD\|235359	PRK05182, PRK05182, DNA-directed RNA polymerase subunit alpha; Provisional.	0
NZ_CP045929.1\|WP_154078073.1\|4313977_4315288_+\|type-VII-secretion-protein-EccE	gnl\|CDD\|274857	TIGR03923, T7SS_EccE, type VII secretion protein EccE. This model represents the transmembrane protein EccB of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccE1, EccE2, etc. This model represents a conserved core region, and many members have 200 or more additional C-terminal residues. [Protein fate, Protein and peptide secretion and trafficking].	4.037e-35
NZ_CP045929.1\|WP_154078064.1\|4299482_4299926_-\|50S-ribosomal-protein-L13	gnl\|CDD\|181703	PRK09216, rplM, 50S ribosomal protein L13; Reviewed.	6.68896e-98
NZ_CP045929.1\|WP_154078075.1\|4316145_4317048_+\|DUF559-domain-containing-protein	gnl\|CDD\|380141	pfam18741, MTES_1575, REase_MTES_1575. Vsr REase Fold. Fused to HEPN (SWT1/Abi2 family), along with Transglutaminase and wHTH.	3.84948e-14
NZ_CP045929.1\|WP_154078065.1\|4300301_4300589_-\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	1.50035e-15
NZ_CP045929.1\|WP_154078066.1\|4300649_4300958_-\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	4.94441e-11
NZ_CP045929.1\|WP_154078077.1\|4318046_4318604_-\|50S-ribosomal-protein-L17	gnl\|CDD\|235522	PRK05591, rplQ, 50S ribosomal protein L17; Validated.	6.33071e-64
NZ_CP045929.1\|WP_154078068.1\|4303660_4307749_-\|type-VII-secretion-protein-EccCa	gnl\|CDD\|274858	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa. This model represents the N-terminal domain or EccCa subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	0
NZ_CP045929.1\|WP_154078072.1\|4312199_4313804_-\|type-VII-secretion-protein-EccB	gnl\|CDD\|368288	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B. EccB is a family of largely Gram-positive bacterial transmembrane componenets of the type VII secretion system characterized in Mycobacterium tuberculosis, systems ESX1-5. Translocation of virulent peptides through the membranes is thought to be mediated via a complex that includes EccB, EccC, EccD, EccE, and MycP. EccB, EccC, EccD, and EccE form a stable complex in the mycobacterial cell envelope.	2.41931e-104
NZ_CP045929.1\|WP_154078069.1\|4308105_4309536_+\|type-VII-secretion-integral-membrane-protein-EccD	gnl\|CDD\|274855	TIGR03920, T7SS_EccD, type VII secretion integral membrane protein EccD. Members of this family are EccD, a component of actinobacterial type VII secretion systems (T7SS) with ten to eleven predicted transmembrane helix regions. [Protein fate, Protein and peptide secretion and trafficking].	7.99215e-50
NZ_CP045929.1\|WP_154078067.1\|4301503_4303348_-\|type-VII-secretion-associated-protein	gnl\|CDD\|212667	cd10170, HSP70_NBD, Nucleotide-binding domain of the HSP70 family. HSP70 (70-kDa heat shock protein) family chaperones assist in protein folding and assembly and can direct incompetent "client" proteins towards degradation. Typically, HSP70s have a nucleotide-binding domain (NBD) and a substrate-binding domain (SBD). The nucleotide sits in a deep cleft formed between the two lobes of the NBD. The two subdomains of each lobe change conformation between ATP-bound, ADP-bound, and nucleotide-free states. ATP binding opens up the substrate-binding site; substrate-binding increases the rate of ATP hydrolysis. HSP70 chaperone activity is regulated by various co-chaperones: J-domain proteins and nucleotide exchange factors (NEFs). Some HSP70 family members are not chaperones but instead, function as NEFs to remove ADP from their HSP70 chaperone partners during the ATP hydrolysis cycle, some may function as both chaperones and NEFs.	1.59704e-79
NZ_CP045929.1\|WP_154078070.1\|4309547_4310963_+\|type-VII-secretion-associated-serine-protease-mycosin	gnl\|CDD\|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	3.03173e-103
NZ_CP045929.1\|WP_154079005.1\|4298913_4299309_-\|30S-ribosomal-protein-S9	gnl\|CDD\|178888	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed.	2.83688e-70

>NZ_CP045929.1|WP_154078070.1|4309547_4310963_+|type-VII-secretion-associated-serine-protease-mycosin
MASSTHSRGRRCLALTAAAGLLALTGPVLPATAQPPAPGQPAESGQPPPQNDAFQPDSGPLSPVGPEYQQQTACMAPNPGGGAIEERPWSQMVLGYEQAHSEELTGEGRKIAVIDTGINPHPFLPPVDDGGSSVPGGGANFDCDGHGTIVAGILAAQPNDGSGFIGVAPDAQLMSLRQSSKLWQTQQDGQTVGDTETMAQAVQHAVDSGANVINISQSSCQAIAQAANPNDPFNGALHTAVKNAYERGVVVVAAAGNVEGACQKNPSGDPTTAVLPAWFDDYVLTVASVNEQGAPSEFTVPGPWVDVAAPGEGLVSLDPGPGGTGLASQIATGQGGELGPIQGTSFAAPYVSGLAALIQERGIEEGQQYSAQQVMERIKKTALSPGGTGGRNDIVGHGMIDPMAALHNVIPAEHGKAPADTGPARLDADVIPQKNWPAIMVALGTTGGGIAALIFTAFLINAVKRVRSRQG
>NZ_CP045929.1|WP_154078069.1|4308105_4309536_+|type-VII-secretion-integral-membrane-protein-EccD
MATGTTVFSRVTVVAPNTRIDVALPADVSVADLMPMLLEMAGQLTNDGGSRHGGWCLAKLGEDEPLDASETLAALRVVDGDMLQLRRRSDNPPPPLYDDVVDALAEAEPGSYRPWTKETAAKIGHAAGALALIAAAVALGIAGAGGVLLQIVAAVTAAVVAIFAVGTGAVVARAYGSATTGTVIAAAGGLPMAFVAGLNIVPGTDLRPKLLLAAALVLIFASVSIMVSGAGIVAFIGAATVGLFGTLALVVATLLGAKATAAGVAAGVAAVGLAGISLLPRLTIQLAKLPLPHVPGSAEDLKEDSSFPDYRVIELQSGRAHEYMTGMIIGCGATAALGAVVAATAPNVWGPLLAVVVAAVLLLRGRNYANSSQAVALLVSGLLAAVGVTVGLLMPVELVGFGTTAAQKLMFVFGPLLLMGIAALIFGVVFPHRRFSPVQRRTVDILEAVLIALVLPLALGVMDLYMTIRDLNLNLF
>NZ_CP045929.1|WP_154078068.1|4303660_4307749_-|type-VII-secretion-protein-EccCa
MSTLQFKRKPRLAAPRPPGGEVHLEPPPEIPRAVPGNIVQKFLPVVMIVASLGMMVFMLQRASNNPMMLMMPMMMLVSTFGMMAGGGQGQGQKKAEMNEDRKDYLRYLGQMRERAREAADEQRLARDWVHPDPQTLWSIAQSPRRLWERRPGDNDFCQVRVGRGSQRLETRLVPPQTGPVDELEPITTLALRRFVRAHSLVSDLPIAISLKGFASVGFQGDRELTRGLVRAILAQLATFHTPDDLVIAVAAGARTRAEWDWVKWLPHAQSPTRTDGLGSVRLIEPSLRGIEEVLDEELAGRQRFQRNAAPPEGQPHVVVVIDDAEISREEEIYLSAGLAGVTVLDLSDVFDPISAKRGMRIVVEPDRVGARSNTGVEWFGEPDTLSATEATALARRLAPYRVAGSGGQAEADTGGYEPLTTHLNYVEQLGLQGDPITFDLGEAWRPRQRDNLYRVAMGPGEQGEIVHLDIKETASGGMGPHGLCIGATGSGKSEFLRTIVLGLIATHPSTSLNFVLVDFKGGATFNGFESAPHVSASISNLGDDTTLVDRMKDALEGEMNRRQEILQKAGAKNVWDYRKQRDAGDEKAQEPLPALFVVIDEFSELLSQKPDFADLFTMIGRLGRSLQVHLLLASQRLEEGKLRGLDSHLSYRIGLKTFNAAESRSAIGIPDAADLPASGGHGYLKHPNGMDRFRAAYVSGHLHQTSGRRPAGAAAAKVTGERRPKLFVADYVEPPPEPEVPEVEEAPKEEKKDDLAPTDFQIVIDKVTNQSPPAHQVWLPPLDAPPTLDGLLPPLSATDDRGYSSVGFSGSGRLQVPVGIIDVPYHQRQDHMMLDLGGASGHGAVVGGPQTGKSNLMRTLIASLALTHTPQEVQCYCVDLGGGSMAALKNLPHVGSYGGRRDVDTVRRTIAELKSLMAEREARFQETAIEGMTDFRNRKRKGEITNDPYGDVFLFIDGWASFRNDFETLEQDVLNLAAQGLTFGIHVIVSANRWAEIRPALKDLIGTRLELCLGDSSESEINRKVAVNVPNGRPGRGVHPSELHFLTALPRVDSEQLAGRIEAEAARAEEEREAPRPGWQLYNDDLADGAADLVNRVRSSWMGRPAPQVRLLPDLLPYEQMPSVDQQPSPKLVPIGVNEDGLNPVYLDFKAEPHFYALAERESGKTALLRTILQGITTRYTPKEALVLLVDYRRTLIGFLNPEHELEYSVSADMLKNNVKDVCAALKKRLPGPDVTQQQLKDRSWWTGPELFVVVDDYELVAPSGNNPLQPLADFVPQAQDVGLHVILARNSGGASRGLYDPVLAKMREVSSPGLAMSANKDEGQLVANIKSRELPPGRGTLVSRSMRGGPQMIQTAFLRPE
>NZ_CP045929.1|WP_154078067.1|4301503_4303348_-|type-VII-secretion-associated-protein
MTLHVAVDFGTSSTCTVVSRDGAEPQVVVIDGQPLVPSAVFAAADGTLFVGQEAERQAAVDPARFEPHPKRRIDDGELLLGSSVLPVVDVIRAVLQRAVGEARRYAGGAAVDLLVLTHPADWGSVRTSVLRAAAQGLGRESVLVPEPVAAAVFHSAGHGLPDGGALAVLDLGGGTVDASVVRKQGSRFPVLATKGRPDFGGADIDQALLEHLGRTVSHVDPGAWHQLVEGREMVDRRRRRVLRQDVRGAKETLSRHAYTDVPMPPPFSDAHVTRTDLERLVAGGLSQAVDLVPGTLREGSVPRQQLAGVFLVGGSSRIPMVSRLVHERTGVVPTTLDQPETVVARGALRAVRLDPDRTGGLPAAAVRGPATPTRAPGVAGAQSPGFAAPQQVTAPEAGSVPASDSLSRASTIVIGGNERTRQVNAPSTPAKPNRTPWLVGAGAAVLVVSALVVGILVIGEDGDARQQAGRTVAQYDYEFEYPATWRQSGGDPEQWQTLIEPRSSATGGGRIAVQEGRLDYDAGADRERAVNEVRGLYDAGVAETGTFSGFRADASFGGKDVVHYREQLPQATVDWFVVHAGTARVSVGCQYTPQSGDEVRRACEQVVRSLTVRD
>NZ_CP045929.1|WP_154078066.1|4300649_4300958_-|WXG100-family-type-VII-secretion-target
MSGFGTDAELMDKAANQVEEVRGNVEQAVSKLQGNLEPMLAQWQGGAAQVFRQLMDSFKQNADTINRNLGQISENIKTSGSQYMQQEEEQSQEMSKIQNMLG
>NZ_CP045929.1|WP_154078065.1|4300301_4300589_-|WXG100-family-type-VII-secretion-target
MEIKVNFGQLSQGASDLQQTSAKIQQELDELESMLKPLVATWEGSAQEAYRAAQAEWDQAAANMQEICAKMGMAVNAANDSYQSGESKNAARFGG
>NZ_CP045929.1|WP_154078064.1|4299482_4299926_-|50S-ribosomal-protein-L13
MRTYSPKAGEVTRAWHVIDAEDVVLGRLATQAATLLRGKHKPTYAPHLDTGDFVVVVNAEKVALTGNKRDQAFQYRHSGYPGGLRKESFGNVLDKHPERLLEKTIKGMLPKNKLGRAMGKKLKVYAGPEHPHQAQNPQTFDVKKVKK
>NZ_CP045929.1|WP_154079005.1|4298913_4299309_-|30S-ribosomal-protein-S9
MPGGRAAQSVGRRKKARARVRLVPGNGGFKLNGKPLEHYFPNKVHQQIIREPFQTVERDEAFDVNANLDGGGPSGQAGALRMAIARALIQLDADDRPALKKAGMLTRDSRAKERKKYGLKKARKAPQYSKR
>NZ_CP045929.1|WP_154078063.1|4297445_4298777_-|phosphoglucosamine-mutase
MSRLFGTDGVRGLANAELTPELALSLSSAAARVLYDRDDSRRRVALVGRDPRASGEMLEAAVTAGLTSAGADVLRVGVLPTPAVAHLVAALGADIGVMISASHNPMPDNGIKLFSAGGNKLPDAVEDEIASRLDETVQRPTGVHVGRVRDAPNAVQQYVDHLLVATPQRLDGVRVVVDCANGAAAYAAPEAYRRAGAEVIPLHADPDGLNINDGVGSTHLESVRAAVLEHGADLGLAHDGDADRCLAVDATGAVVDGDQIMAMLAVDMCESGELAADTLVATVMSNLGLHLAMREHGVTLRTTAVGDRYVLEELRAGAYSLGGEQSGHVVLPGYATTGDGLLTGLRIMSRMAGTGRGLAELAAVMTRLPQVLVNVRVDDKHAVVAAPQVTEAVAVAEAELGESGRVLLRKSGTEQLVRVMVEAPSGEIAQETADRLAKVVGGA
>NZ_CP045929.1|WP_154078062.1|4296730_4296949_-|hypothetical-protein
MGVGVGGVGAWELALALGFLFGKAVLILLVVGGSVAAILFLARSHKRSQPSAHRDRYGPASRSGQPPDHGHH
>NZ_CP045929.1|WP_154078071.1|4311135_4312023_-|hypothetical-protein
MAPEPVDAFGGVGRSLGASDAYERVSRALLDETGRLGERWFGDVGLASNDVVDAIREWADALDRAAEALRIVGEKFADHVAETAENVSAAVVPGVEQGRVRRLLLDAEEPARELVRSAENVVRDFVRFCDEFDSGRGVSEQTPLRSASQHAYGSPAPQSASARQEGASGSEAVSASTGSGAPSVGGADGVSPVDAESSCSQFAECGRPSPEEVPESPVPAAAAGTGHAGSAAAAVGGTWGGGMVGAMPMAGMMGRNQESPRQNASRLKASPEDLFGKPDHTAPAIFGAPQKRPLE
>NZ_CP045929.1|WP_154078072.1|4312199_4313804_-|type-VII-secretion-protein-EccB
MASTPTTKSQVQAYKFVVRRMESALVRKDSVMLHDPMGSHKRATIGGVVLACIGCIGFLVWGLFGGKGSVPDPGSVVIAKESGSVYVVTADDAADKRLIPMLNMASAKLLVMAQGGGGQGQAIEPTTVKEAALAEFPRGPRTGMPNAPEFLPSANDQAPAAWAVCDQADVNEALGQQRAEESAKISTTVMGGVTDHGQRLRDDQSLFVQDTASGQQYLVYNVDPNLSDRPSSTHTVKARINPNEAAVTEMYGLNQAVPRQVSTHMLNAIPEVAPLELPQVPNQGGTSPNLPRGQAIGDVVKQTVPGDADQFFLLLGNGKQPISAGAAAVMHASRTNSTNIDAIPNTTGQLPNVNDVPEGIEQLGNFPAKVPDPVPFRDFNSSCLSWVDNGGNHEIRATLYRDEVNTPKAPVKLAQADDAGPSVDHFFMPPGKAAVVHGNTNEAGSGIGPTYFVSDQGVVYGVKDAPTAQGLGVINAPGDIKDAPGWVMRTLPKGDYLDPAQASFVYDSIEVQEGVNRPPENENGAAAAGGPAGG
>NZ_CP045929.1|WP_154078073.1|4313977_4315288_+|type-VII-secretion-protein-EccE
MAVNTQHPAQQQEAPGQPGAARPARIRARRRTIGASLGFMPVANIIVIEIGLAIGLILVLVNTALWPVAAGVAGLALVIALLRRKGRWFTQWCGLVLEYAMRDHIRVSEPPVTQFDDDETGDRQDDTKLIGGENHRVALLRLAVPGLVVASRDDHNHNPVGMAWNNGTWSAVLMVEPTPSLINEIGSDTNLPLSALSGCLEDRGVVLDSIQVLWHCYPGSAALPANSPALNAYLDLLGPRPAAARRTTWIVVRLDPQRCAKAVQERGGGVVGAHRALIGALSRVRNAMERSGVSTRPLAPDELLQAGITSAELNDSLRTPRPVGLQERWSGVTAGGVGHTSFAITGWPSQMGKPLNEITGVRALSTTIAMEISPSGEPDEVGLRGLVRVSARVPSELSAAETQLQSVSKKVGITLTPLRGLQISGFSSTIPLGGAA
>NZ_CP045929.1|WP_154078074.1|4315284_4316031_+|hypothetical-protein
MSRTRAVDKPGNPHGAAPQFLIDPEALDTIAPSGDRGGVLVGASPHGKPLSASVLRPQPTRMVMVGGLYLARQIALRSLATGAWVQIATGRPAAWKMLERAAGLAPDGRPVPSMQIKKLAPFELPTATEDAPLLVIHDGGAVPQELFPPRSPWQTTLYVLPYLHPQVGNGTTANGADLVLLQRLPLNQAELAARIWHLDPATKQRQVNELTQLPDDIVIALGNNLWEPIQLGTKPAESEILGPVRRGD
>NZ_CP045929.1|WP_154078075.1|4316145_4317048_+|DUF559-domain-containing-protein
MDETARSDWLARRVTPTETRFGLFTRAEALSRGVTDRRLRSGEFGRVLQGVYCPGDKPIDHELRCHAAALVLPPSAVLTGRSAATLHGVPLAKTWDHVEALVSGAKYMNRRKGLRCWSVRSRPAEHRPWHGIRLATPLRTAFDLLARKPLRQAVASCDAMLHACVIQLPDLVRFLAGRSDRGITRARIALQHLDARSESVPESELRLLLNWNGFPVEPQVQVHDEFGFVARVDLALRSRKVAIEYDGAWHGNPAQFARDRIRQQRLERCGWTVVVVTAKDLYGSPDDVVANVHQAARIKA
>NZ_CP045929.1|WP_154078076.1|4317144_4318026_-|tRNA-pseudouridine(38-40)-synthase-TruA
MNEPVAPSGGGGFVRLRLDVAYDGAGFSGWARQPGLRTVQGLLEDALAKQPPGRSVVKSVVVAGRTDAGVHAHGQVVHVDVEPFSPGESGRVPAGERGVPDLERMCARWNRILPGDVRVLGARLAPDGFDARFSALRRHYRYQVSDAPWGADPLRRGDTLAWNRPLDVDRMNRGAQELLGLNDFAAFCKQREGATTVRELQRFDWRRVDQNLVVAQVSADAFCHSMVRSLVGALLMVGDGRREPSWAVEILAAGVRTSAVAPPHGLALVGVDYPDDEHLAARAARIRAVRTLP
>NZ_CP045929.1|WP_154078077.1|4318046_4318604_-|50S-ribosomal-protein-L17
MPTPTKGARLGGSPAHERLMLANLATSLFEHGRITTTEAKAKRLRPLAERLITKARKGDLHNRREVMKTIRDKDIVHKLFAEIGPFFADRHGGYTRIVKTMPRRGDNAPMAVLALVTEKTATSEAEAARGTKFAKDQQQAPVAEETTESTESTDASETEVSEAAASGESAESAEDTEGAEKKDES
>NZ_CP045929.1|WP_154078078.1|4318655_4319747_-|DNA-directed-RNA-polymerase-subunit-alpha
MLISQRPTLAEEAVSETRSRFVIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSLRIDGVLHEFTTIPGVKEDVTDVILNLKELVVSSEEDEPVTMYLRKQGPGEVTAADIVPPAGVTVHNPDLHIAHLNGKGKLEIELVVERGRGYVPAVQNKQAGAEIGRIPVDSIYSPVLKVTYKVEATRVEQRTDFDKLILDVETKPSITARDAVASAGRTLVELFGLARELNVDAEGIEIGPSPAEADTIAAYAMPIEDLDLTVRSYNCLKREGIHTVGELVSRSEADLLDIRNFGAKSIDEVKLKLVGLGLALKDSPPGFDPTAAAAEYPGEGWSADEGAIEGVSLDEGGFDDGGFDDGQDYAETEQL
>NZ_CP045929.1|WP_154078079.1|4319895_4320501_-|30S-ribosomal-protein-S4
MARYTGPATRKSRRLKVDLIGGDTAFERRPYPPGQHGRARIKETEYLLQLQEKQKARYTYGVLERQFRSYYEEANRRPGKTGENLLQLLESRLDNVVYRAGLARTRRMARQLVNHGHFLVNGKKVDIPSFEVSKFDIIDVKPKSLATTPFVIAKETLGERPVPAWLQVVPSNLRVLVHQRPERAQIDTPVTEQLIVELYSK
>NZ_CP045929.1|WP_154078080.1|4320524_4320929_-|30S-ribosomal-protein-S11
MPPKSRAGAVKKVRRKEKKNVAHGQAHIKSTFNNTIVSITDPTGGVISWASAGHVGFKGSRKSTPFAAQMAAENAARKASEHGMKKIDVFVKGPGSGRETAIRSLQAAGLEVGTIQDVTPQPHNGCRPPKRRRV

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Crispr_ID: NZ_CP045929_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045929_10

4376662-4376756

TypeV-U4

Consensus_repeat	Method
GGAGCGAACGGCACTTTCGCCCCACCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP045929_10

>merge|NZ_CP045929|10|4376662-4376756|CRISPRCasFinder
GAGGCGAACGGCACTCTCGCCTCACGAGACGAGGCGAACGTGCCGTTCGCACCAAACGCACATCTCGTGGAGCGAACGGCACTCTCGCCCCACCA

>NZ_CP045929|10|10|4376662-4376756|CRISPRCasFinder
GAGGCGAACGGCACTCTCGCCTCACGA	GACGAGGCGAACGTGCCGTTCGCACCAAACGCACATCTCGT
GGAGCGAACGGCACTCTCGCCCCACCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045929.1\|WP_154078133.1\|4377750_4378185_-\|50S-ribosomal-protein-L11	unknown	unknown	gnl\|CDD\|234661
NZ_CP045929.1\|WP_154078135.1\|4379335_4379740_-\|preprotein-translocase-subunit-SecE	unknown	unknown	gnl\|CDD\|376355
NZ_CP045929.1\|WP_154078130.1\|4374946_4375468_-\|50S-ribosomal-protein-L10	unknown	unknown	gnl\|CDD\|234632
NZ_CP045929.1\|WP_154078125.1\|4369924_4371307_-\|MCE-family-protein	unknown	unknown	gnl\|CDD\|378749
NZ_CP045929.1\|WP_154078128.1\|4372978_4374193_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224052
NZ_CP045929.1\|WP_154078129.1\|4374499_4374886_-\|50S-ribosomal-protein-L7/L12	unknown	unknown	gnl\|CDD\|234671
NZ_CP045929.1\|WP_154078134.1\|4378337_4379213_-\|transcription-termination/antitermination-protein-NusG	unknown	unknown	gnl\|CDD\|180161
NZ_CP045929.1\|WP_154078132.1\|4376958_4377678_-\|50S-ribosomal-protein-L1	unknown	unknown	gnl\|CDD\|180071
NZ_CP045929.1\|WP_154078136.1\|4380124_4381363_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|235596
NZ_CP045929.1\|WP_154078137.1\|4381512_4381935_-\|dehydratase	unknown	unknown	gnl\|CDD\|239537
NZ_CP045929.1\|WP_154078141.1\|4386153_4386459_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045929.1\|WP_154078123.1\|4367922_4368903_-\|MCE-family-protein	unknown	unknown	gnl\|CDD\|273384
NZ_CP045929.1\|WP_154078140.1\|4383076_4385713_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NZ_CP045929.1\|WP_154078139.1\|4382506_4382671_-\|50S-ribosomal-protein-L33	unknown	unknown	gnl\|CDD\|234783
NZ_CP045929.1\|WP_154078124.1\|4368899_4369928_-\|MCE-family-protein	unknown	unknown	gnl\|CDD\|273384
NZ_CP045929.1\|WP_154078122.1\|4366717_4367926_-\|MCE-family-protein	unknown	unknown	gnl\|CDD\|273384
NZ_CP045929.1\|WP_154078138.1\|4381931_4382396_-\|MaoC-family-dehydratase	unknown	unknown	gnl\|CDD\|379194
NZ_CP045929.1\|WP_154078131.1\|4375819_4376653_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045929.1\|WP_154078127.1\|4372148_4372982_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223838
NZ_CP045929.1\|WP_154078126.1\|4371303_4372143_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223838

Protein	Function_ID	Function_description	E-value
NZ_CP045929.1\|WP_154078133.1\|4377750_4378185_-\|50S-ribosomal-protein-L11	gnl\|CDD\|234661	PRK00140, rplK, 50S ribosomal protein L11; Validated.	2.14729e-91
NZ_CP045929.1\|WP_154078135.1\|4379335_4379740_-\|preprotein-translocase-subunit-SecE	gnl\|CDD\|376355	pfam00584, SecE, SecE/Sec61-gamma subunits of protein translocation complex. SecE is part of the SecYEG complex in bacteria which translocates proteins from the cytoplasm. In eukaryotes the complex, made from Sec61-gamma and Sec61-alpha translocates protein from the cytoplasm to the ER. Archaea have a similar complex.	5.48633e-23
NZ_CP045929.1\|WP_154078130.1\|4374946_4375468_-\|50S-ribosomal-protein-L10	gnl\|CDD\|234632	PRK00099, rplJ, 50S ribosomal protein L10; Reviewed.	6.5137e-64
NZ_CP045929.1\|WP_154078125.1\|4369924_4371307_-\|MCE-family-protein	gnl\|CDD\|378749	pfam11887, Mce4_CUP1, Cholesterol uptake porter CUP1 of Mce4, putative. Mce4_CUP1 is a family of putative Mce4 transporters of cholesterol. The domain is found associated with pfam02470. The full TCDB classification for this family in conjunction with PF02470 is TC:3.A.1.27.4.	6.34548e-86
NZ_CP045929.1\|WP_154078128.1\|4372978_4374193_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224052	COG1127, Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism].	4.76877e-117
NZ_CP045929.1\|WP_154078129.1\|4374499_4374886_-\|50S-ribosomal-protein-L7/L12	gnl\|CDD\|234671	PRK00157, rplL, 50S ribosomal protein L7/L12; Reviewed.	6.00101e-42
NZ_CP045929.1\|WP_154078134.1\|4378337_4379213_-\|transcription-termination/antitermination-protein-NusG	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	4.6871e-92
NZ_CP045929.1\|WP_154078132.1\|4376958_4377678_-\|50S-ribosomal-protein-L1	gnl\|CDD\|180071	PRK05424, rplA, 50S ribosomal protein L1; Validated.	1.01027e-143
NZ_CP045929.1\|WP_154078136.1\|4380124_4381363_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|235596	PRK05764, PRK05764, aspartate aminotransferase; Provisional.	0
NZ_CP045929.1\|WP_154078137.1\|4381512_4381935_-\|dehydratase	gnl\|CDD\|239537	cd03453, SAV4209_like, SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.	4.12985e-56
NZ_CP045929.1\|WP_154078123.1\|4367922_4368903_-\|MCE-family-protein	gnl\|CDD\|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	3.19534e-57
NZ_CP045929.1\|WP_154078140.1\|4383076_4385713_-\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	2.2365e-99
NZ_CP045929.1\|WP_154078139.1\|4382506_4382671_-\|50S-ribosomal-protein-L33	gnl\|CDD\|234783	PRK00504, rpmG, 50S ribosomal protein L33; Validated.	3.5287e-20
NZ_CP045929.1\|WP_154078124.1\|4368899_4369928_-\|MCE-family-protein	gnl\|CDD\|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	3.84332e-56
NZ_CP045929.1\|WP_154078122.1\|4366717_4367926_-\|MCE-family-protein	gnl\|CDD\|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	1.04936e-50
NZ_CP045929.1\|WP_154078138.1\|4381931_4382396_-\|MaoC-family-dehydratase	gnl\|CDD\|379194	pfam13452, MaoC_dehydrat_N, N-terminal half of MaoC dehydratase. It is clear from the structures of bacterial members of MaoC dehydratase, pfam01575, that the full-length functional dehydratase enzyme is made up of two structures that dimerize to form a whole. Divergence of the N- and C- monomers in higher eukaryotes has led to two distinct domains, this one and MaoC_dehydratas. However, in order to function as an enzyme both are required together.	2.36407e-37
NZ_CP045929.1\|WP_154078127.1\|4372148_4372982_-\|ABC-transporter-permease	gnl\|CDD\|223838	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	1.8809e-71
NZ_CP045929.1\|WP_154078126.1\|4371303_4372143_-\|ABC-transporter-permease	gnl\|CDD\|223838	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	1.74889e-66

>NZ_CP045929.1|WP_154078131.1|4375819_4376653_+|hypothetical-protein
MADPNEPTHSPRGHDAQDEVLDAEIVDEPRRDDAGRDGPAAGASGFRDDEEYRQYQEFLEFQKFREWQRNRSDGARTSFTGETKRSREPQARPRWKRALGLLRYKTVRRLLYLLVAVLFAWWLLHYLLGDIMDNGDSTAPDGGTPGKQDFSTAPIPSADPATAVAGVYNYVAYNRAGDACALFNEAGRQAFADSYGAASCVAAVQRINADVADPVQYPNIKIGRDAETTEGGNSSVSSCGLDVQGGPRLGMFHLTQNAKGGWLIAGHEHEPADCLTG
>NZ_CP045929.1|WP_154078130.1|4374946_4375468_-|50S-ribosomal-protein-L10
MAKAEKVDAVDEIAERFTTATAAVVTEYRGLSMSQLVDLRRSLGAGATYRVAKNTLVKRAAEKSGVEGLEDLFVGPTAITFIEGEPVDAAKALKTFAKDHKALVIKGGYMDGRPISVSEVEALADLDSREVTLGKLAGAMKAKLNETAGLFAAPASQVARMTAALKDKKSDEG
>NZ_CP045929.1|WP_154078129.1|4374499_4374886_-|50S-ribosomal-protein-L7/L12
MAKLSNDELLDVFKEMTLLELSEFVKQFEETFDVTAAAPVAAAAPGAAPAAAEAEEEQDEFDVILDDAGDKKIQVIKVVREVVSGLGLKEAKELVENAPKPIAEKVDKEKADEIKSKMEESGAKISVK
>NZ_CP045929.1|WP_154078128.1|4372978_4374193_-|ATP-binding-cassette-domain-containing-protein
MGVKVVVEGLSKSFGAQTIWRDVTLTLPPGEISVLLGPSGTGKSVFLKALIGLLKPEEGQVVIDGVDVCSCSDSDLYDIRKMFGVLFQDGALFGSMNLYDNIAFPLREHTRKSESQVRDVVMEKMEMVGLVGSESKLPGEISGGMRKRAGLARALVLDPQIILFDEPDSGLDPVRTAYINQLIVDLNAQVDATFLIVTHDIGTARTVPDNIGMLFRRELVMYGPREVLLSSNEPVVEQFLNGRTQGPIGMSEEKDAGQMAAELAELGKDQGVPHIVPQLDVSQGLPRRTAVQRRQDRVMANLGSLTPAAQQEILSTLTVQEKQRYGVTDSGVVTRPPNQRTESMAGSLSTEEVAKVPAGAAQGQRPSPTPRTSGAEDDAFWAPGESVSEQPAKRGWFGRKRGGK
>NZ_CP045929.1|WP_154078127.1|4372148_4372982_-|ABC-transporter-permease
MTTQASPRTAPRRPRGPKWSASLPGAPALRETGKLFALGLDVLVGIFRRPFQIREFIQQCWFIASVTILPTALVAIPFGAVIALQLGSLTRQIGAQSFTGAASVLAIIQQAAPIVTALLIAGAGGSAICADLGSRTIRDEIAAMEVLGVSAVQRLVVPRVLAAMLVAVLLNGMVSVVGVMGGYFFNVILQGGTPGAYMASFNALAQLPDLWISEIKALIFGFIAGVVAAYRGLNPPPGPKGVGDAVNQSVVITFLLLFAVNFILTTIYLNIVPPKGM
>NZ_CP045929.1|WP_154078126.1|4371303_4372143_-|ABC-transporter-permease
MATLTQRARRAARRPLDTLDDLGDQMSFYLRALAWIPKAITQYFKETLRLLAEVSFGSGALAVIGGTVGVMIGLTVFTGTVVGLQGYAALNQLGTSAFAGFISAYFNTREIAPLVAGLALSATVGSGFTAQLGAMRISEEIDALEVMGVPSLPYLVTTRVMAGFVAVIPLYVLGLLTSYLASRTVTVYLYGQSAGTYDHYFNLFLPPEDVLYSFGKVLIFSVVVIMTHCYYGYRASGGPAGVGVAVGRAVRTAIVTTAVLNIFLSLAIWGTTTTVRIAG
>NZ_CP045929.1|WP_154078125.1|4369924_4371307_-|MCE-family-protein
MSAQGALKTVRRRMLGVALLVVIALFLSLTVASYQKAFRSTVDVTLQAGSSANQLLPNSDVKVRGMIIGEVRDIATNGDGAEMQLAIEPDKAEMIPSNVSARLLPKTLFGERYVSLELPQNAGADNIASGDVIQQDRSKASIELEKVLADTMPVLQAVQPDDLAATLNALSQALEGRGKPLGETLSQLNTYLEGFNPSVPQLQENLQQLVGFAETYEQAAPDLLNALENFSTTSRTMVEQRDNLATLNSQLTTTSNDMTAFLEANGDNIIRLGEQSRPNLDLLAKYSPSYPCFLGEMAEFVPRVNEVFGKGTNEPGLHITLEVNQNRGKYEPNQDEPEFNDKRGPRCYPHDQLPSPFPQYPPESDGGPIQDGSTPPPSRNTVEGPSGKPPNTGGEAQTSGPQSTSPQGTGSGLGVVNSPAERDFVSALLAPTMGVPANEVPEWGSLLVGPVLRGAEVSYR
>NZ_CP045929.1|WP_154078124.1|4368899_4369928_-|MCE-family-protein
MNARSIAGPLTKFIIFVLVTLLATFVLVLTIANTDLRASDSYTARFTDATALEEGDEVRISGVKVGEVEAVRVHDNRLAEVDFSVGERRVPKSAKAIIKYRNLIGQRYIALEQGPGNPGDYLPAGGMIPQEQTKPALDLTALLGGFKPLFQALSPEDVNKLSFEIIQVLQGEGGTVESLLARTASLTSTIAQKDQVIGEVITNLNGVLDTVNARDQELSGLIVQLQQVVSGLAADREPIGDAITALDGLTNTTAGLLNEARPPLKEDIARLGGLAKNLNDNEVITERVLKNMPNKLDTITRTATHGSWFNFYLCKAGGQVDVGENTKINVPLQPVTQPRCRR
>NZ_CP045929.1|WP_154078123.1|4367922_4368903_-|MCE-family-protein
MMSFQKRDPLKIGVAGVLVLVLGFFAAMNYQDLPLIGGKTYEAHFSEAAGLKADNEVRVAGVKVGTVRDVELEGDHVLVTFDVDQGWVGDNSSAAIKIKTLLGQKYLALEPKGLEELSTSEPIPMERTMAPYDVVEAFQGLSQTVDQVDTNQLADSFRVMSDTFSDTPDEVRGALDGLSALSQTIAKRDDELRKLLENTSQVSKTVSDRNAEFEKLLADGNLLLQEIRDRREAISGLLDGTRALSAELTGLVDDNQAQLGPTLQQLERVTGMLERNQESLDASIQKFEPFTRLFSNVLGNGRWFDTYICGLLPPAVGPINPEGCNP
>NZ_CP045929.1|WP_154078122.1|4366717_4367926_-|MCE-family-protein
MSPAAVAGRRFGARSLAILCVLALVISGAAWWVFSNAAERKITAYFSAAVGVYPGGDVRMLGVPIGSIDTVQPQGETVKVTFDLENDVEVPADANALVVTPSVVADRYVQLAPVYKGGPQMQNGATIPKERTATPVELDQVYKSLNDLSTALGPEGANKDGALSELLDTSAQNLKGNGKALSDMLQNLGDAGKTLSGNSKELFATVENLQKFTTMLAENDAKVREFNTQMQDVSSLLAGEREDLGAALAELAVALDKVESFIRDNREALKSNVDKLTSVSQVLVDQKAALAKSLDHAPVALGNLQNAYNASSGTLDTRAVMNQMAQPPLVSVCQLVKDKQEKQGIPFPEQLLGPCGKVDELLSQGKPLTPDLLGGQGAPGDSGTQSAPALPLDGLTKLGGGQ
>NZ_CP045929.1|WP_154078132.1|4376958_4377678_-|50S-ribosomal-protein-L1
MTKRSKAYREVAELVDSTRLYAPKEAVELAKKTAKTNMDPTVEVALRLGVDPRKADQMVRGTVNLPHGTGKTVRVIAFATGDKAAEAEAAGAEAAGSEDLIERIQGGWLDFDAAIATPDQMAKVGKIARVLGPRGLMPNPKTGTVTPNVTKAIEDIQGGKISFRVDKQANLHLIIGKASFDTSKLVENYTAALDEVLRSKPSTSKGRYLRKVTFTTTMGPGIPVDPNRTRNLLEETVSA
>NZ_CP045929.1|WP_154078133.1|4377750_4378185_-|50S-ribosomal-protein-L11
MPPKKKRLSAIIKLQIQAGQANPAPPVGPALGQHGVNIMEFCKAYNAATESQRGDVVPVEISVFEDRSFDFKLKTPPAAKLLLKAAGVQKGSGEPHKSKVGKVSMDQIHEIAQTKMVDLNANDADQAAKIIAGTARSMGLTVES
>NZ_CP045929.1|WP_154078134.1|4378337_4379213_-|transcription-termination/antitermination-protein-NusG
MTSHEGQELASLSDEQVHAEAVETAEAETESDEGVGSDQAADSGEDTVSTDDHGGATEAADESTAGADEAVAADGAEGTADAEPEETDPVEELRAALRRAPGEWYVVHSYAGYENKVKTNLETRAQTLDVEDFIFQVEVPTEEVTEIKNGQRKTVQRKVLPGYILVRMELNDSSWSAVRNTPGVTGFIGATNNPSPLTINDVLKFLAPRVEKEAKPETGKKAPQQQPASGEQAPEVDFEVGESITVMDGPFATLPATISEVNADNQKLKVLVSIFGRETPVELSFTQVSKI
>NZ_CP045929.1|WP_154078135.1|4379335_4379740_-|preprotein-translocase-subunit-SecE
MSEDREQERNGNDEEASRPSGAAARRERRASARSSAAGRGSAGSGSDDAGAATTEPKGRATPARDGRQQGRTSPIATVVRFVREVVAELRKVIWPTRKSLVQYTLVVLVFSVVMVSFIAGVDLLFARGVLWLFG
>NZ_CP045929.1|WP_154078136.1|4380124_4381363_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MSAPDAQSPDSTAARRVSARIGGISESATLAVDAKAKALKAAGHPVIGFGAGEPDFPTPQTVVEAAEQACADPRNHRYSPASGLPELREAIAAKTLRDSGYAVDASQVLVTNGGKQAVYQAFATLLDPGDEVLLPAPYWTTYPEAISLAGGVPVTVETDDSTGFVATVEQLEAARTERTKVLLFNSPSNPTGGIYPREQIEAIGRWAVEHGVWVITDEIYEHLTYGDAEHVSMPVVVPELADTCVVLNGVAKTYAMTGWRVGWMIGPTDVIKAATNLQSHLSSNVCNVAQRAALEAVSGSLDAVADMRTAFDRRRRTIVDLLSAIPGVSCPEPQGAFYAYPSVKELLGKEIRGSVPNTSVELAALILEHAQVAVVPGEAFGTPGYFRLSYALGDEDLAEGLRRMADLLKEAK
>NZ_CP045929.1|WP_154078137.1|4381512_4381935_-|dehydratase
MTPTLSEVTVGDELPALTVPVTRADLVRYAGASGDFNPIHWNERFATEVGLPDVIAHGMLTMALAGRIVTEWAGDPGAVARYSVRFTRPVVVPDDGVGTEITVTGKVAAINEDGTVKVTITAKAADQAVLGGAQAHVRLP
>NZ_CP045929.1|WP_154078138.1|4381931_4382396_-|MaoC-family-dehydratase
MPLDQAFIGREYPPTPPYEVGREKIREFADAVHDDSEVCRDTDAAKAAGHPDVIAPPTFAVILSMGAHDALVGDPELGLDYSRVVHGQQEFVHHRPIRAGDRLVTVVHVDDIMARAGNDFLTVRAEVGSVDGERVCTATSLLVARGTAEEGDQA
>NZ_CP045929.1|WP_154078139.1|4382506_4382671_-|50S-ribosomal-protein-L33
MATTDVRPKITLACEECKNRNYITRKNRRNDPDRLAMKKFCTNCGTHRVHKETR
>NZ_CP045929.1|WP_154078140.1|4383076_4385713_-|EAL-domain-containing-protein
MIERHRSLDPHAPPDAPRPPVRAEVEPGRRKVFLWFSLSVFVAGVVACVATSVWLPFDYDPQLLLIGACLTLGFLLAEQLTIDIDVKRVGWTISFTEIPLLIGLLTAPFEVVLLANLIAGLVAQVGRRASTHMVYNAGVMGLEIAVPFATAHAITRSLGDVAPDWFGAAVGTLTCSLLSCGFALAALHALGGGTRVTAGVRLGVRTLVIGVFNTSVGLVGYEVAVMTPWGWALVALLSAAVFGLYRAYSGLLREQRDLESLSDVSLSVARSGQTATRGPSGSALVEQDPMAEWEPVAERIREQLNATRVVLRLRLGPTGEVSTLVAGEPLPEAAEQAGPHALREDPLMQLPGSHARSFRAHDAPEEVRRALRQRGAYESLAVPLRGASQLLGAVEVHDRVSRWRGFGRADIRLLHTLASHLATAMDNRRLLARLRHDAYHDPLTGLFNRTGFREVAAEVLRNGGDAAVLRVDLDLLTEVSEAVGYTWGDRMVVHAGHRMRETLGDGAPLARLEAHSFAALLLDHSDEEAHDVAEQVREVISEPYPLDKLVVEATGVAGYASPAPDDGGESETDVDTLLQRADLAVRAARNGDDGVRRYATAMGQVFLRRFQLVTQFRQALDAGQIEVHYQPKVALPHRKLVGAEALVRWSHPEYGRLSPDEFVPVVEATGLVDALTFFVLERALTKVREWMDRGLRMSAAVNLSVRNLADESFPDRVAEALQQANVPPELLTFELTESSVMADPDRSLPVLRRLRTMGVVLAVDDFGTGYSSLAYLRQLPVDEVKIDKSFVLGMGTDLGDMAVVRSIVELGHSLDLVVVAEGVEDDAARDQLVTMRCDIAQGYLISRPLSEDRFEAWLHARTERGVGPADETILTLAQ
>NZ_CP045929.1|WP_154078141.1|4386153_4386459_+|hypothetical-protein
MQDPTTPLVATADLDGLAGAFTVLDTHAELNHRYRKLIEDSYAQLAAERVRLTQARGMAKKVQVLVRAAGPEFRDTLGEPERTALDAGLTQAETLIQHAHP

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP045929_7	7.1\|3617178\|30\|NZ_CP045929\|CRISPRCasFinder	3617178-3617207	30	NZ_CP045929.1	365336-365365	0	1.0
NZ_CP045929_7	7.1\|3617178\|30\|NZ_CP045929\|CRISPRCasFinder	3617178-3617207	30	NZ_CP045929.1	559479-559508	0	1.0
NZ_CP045929_7	7.1\|3617178\|30\|NZ_CP045929\|CRISPRCasFinder	3617178-3617207	30	NZ_CP045929.1	110270-110299	1	0.967
NZ_CP045929_7	7.1\|3617178\|30\|NZ_CP045929\|CRISPRCasFinder	3617178-3617207	30	NZ_CP045929.1	3437856-3437885	1	0.967
NZ_CP045929_3	3.1\|960228\|42\|NZ_CP045929\|CRISPRCasFinder	960228-960269	42	NZ_CP045929.1	504826-504867	2	0.952
NZ_CP045929_3	3.1\|960228\|42\|NZ_CP045929\|CRISPRCasFinder	960228-960269	42	NZ_CP045929.1	798862-798903	2	0.952
NZ_CP045929_3	3.1\|960228\|42\|NZ_CP045929\|CRISPRCasFinder	960228-960269	42	NZ_CP045929.1	4003292-4003333	2	0.952
NZ_CP045929_3	3.1\|960228\|42\|NZ_CP045929\|CRISPRCasFinder	960228-960269	42	NZ_CP045929.1	4376830-4376871	2	0.952
NZ_CP045929_3	3.1\|960228\|42\|NZ_CP045929\|CRISPRCasFinder	960228-960269	42	NZ_CP045929.1	4743695-4743736	2	0.952
NZ_CP045929_7	7.1\|3617178\|30\|NZ_CP045929\|CRISPRCasFinder	3617178-3617207	30	NZ_CP045929.1	2007569-2007598	2	0.933
NZ_CP045929_7	7.1\|3617178\|30\|NZ_CP045929\|CRISPRCasFinder	3617178-3617207	30	NZ_CP045929.1	3814876-3814905	2	0.933
NZ_CP045929_7	7.1\|3617178\|30\|NZ_CP045929\|CRISPRCasFinder	3617178-3617207	30	NZ_CP045929.1	303245-303274	2	0.933
NZ_CP045929_7	7.1\|3617178\|30\|NZ_CP045929\|CRISPRCasFinder	3617178-3617207	30	NZ_CP045929.1	549104-549133	2	0.933
NZ_CP045929_7	7.1\|3617178\|30\|NZ_CP045929\|CRISPRCasFinder	3617178-3617207	30	NZ_CP045929.1	3979713-3979742	2	0.933
NZ_CP045929_7	7.1\|3617178\|30\|NZ_CP045929\|CRISPRCasFinder	3617178-3617207	30	NZ_CP045929.1	4084786-4084815	2	0.933
NZ_CP045929_7	7.1\|3617178\|30\|NZ_CP045929\|CRISPRCasFinder	3617178-3617207	30	NZ_CP045929.1	4096956-4096985	2	0.933
NZ_CP045929_7	7.1\|3617178\|30\|NZ_CP045929\|CRISPRCasFinder	3617178-3617207	30	NZ_CP045929.1	4107783-4107812	2	0.933

1. spacer 7.1|3617178|30|NZ_CP045929|CRISPRCasFinder matches to position: 365336-365365, mismatch: 0, identity: 1.0

cgaggcgaacggcactttcgccccaccaca	CRISPR spacer
cgaggcgaacggcactttcgccccaccaca	Protospacer
******************************

2. spacer 7.1|3617178|30|NZ_CP045929|CRISPRCasFinder matches to position: 559479-559508, mismatch: 0, identity: 1.0

cgaggcgaacggcactttcgccccaccaca	CRISPR spacer
cgaggcgaacggcactttcgccccaccaca	Protospacer
******************************

3. spacer 7.1|3617178|30|NZ_CP045929|CRISPRCasFinder matches to position: 110270-110299, mismatch: 1, identity: 0.967

cgaggcgaacggcactttcgccccaccaca	CRISPR spacer
cgaggcgaacggcactttcaccccaccaca	Protospacer
*******************.**********

4. spacer 7.1|3617178|30|NZ_CP045929|CRISPRCasFinder matches to position: 3437856-3437885, mismatch: 1, identity: 0.967

cgaggcgaacggcactttcgccccaccaca	CRISPR spacer
cgaggcgaacggcactctcgccccaccaca	Protospacer
****************.*************

5. spacer 3.1|960228|42|NZ_CP045929|CRISPRCasFinder matches to position: 504826-504867, mismatch: 2, identity: 0.952

ggcacgttcgcctcgtctggtgaggcgaaagtgccgttcgct	CRISPR spacer
ggcactttcgcctcgtctgatgaggcgaaagtgccgttcgct	Protospacer
***** *************.**********************

6. spacer 3.1|960228|42|NZ_CP045929|CRISPRCasFinder matches to position: 798862-798903, mismatch: 2, identity: 0.952

ggcacgttcgcctcgtctggtgaggcgaaagtgccgttcgct	CRISPR spacer
ggcactttcgcctcgtctggtggggcgaaagtgccgttcgct	Protospacer
***** ****************.*******************

7. spacer 3.1|960228|42|NZ_CP045929|CRISPRCasFinder matches to position: 4003292-4003333, mismatch: 2, identity: 0.952

ggcacgttcgcctcgtctggtgaggcgaaagtgccgttcgct	CRISPR spacer
ggcactttcgcctcgtgtggtgaggcgaaagtgccgttcgct	Protospacer
***** ********** *************************

8. spacer 3.1|960228|42|NZ_CP045929|CRISPRCasFinder matches to position: 4376830-4376871, mismatch: 2, identity: 0.952

ggcacgttcgcctcgtctggtgaggcgaaagtgccgttcgct	CRISPR spacer
ggcacgttcgcctcgtctggtggggtgaaagtgccgttcgct	Protospacer
**********************.**.****************

9. spacer 3.1|960228|42|NZ_CP045929|CRISPRCasFinder matches to position: 4743695-4743736, mismatch: 2, identity: 0.952

ggcacgttcgcctcgtctggtgaggcgaaagtgccgttcgct	CRISPR spacer
ggcactttcgcctcgtctcgtgaggcgaaagtgccgttcgct	Protospacer
***** ************ ***********************

10. spacer 7.1|3617178|30|NZ_CP045929|CRISPRCasFinder matches to position: 2007569-2007598, mismatch: 2, identity: 0.933

cgaggcgaacggcactttcgccccaccaca	CRISPR spacer
cgaggcgaacggcaccttcaccccaccaca	Protospacer
***************.***.**********

11. spacer 7.1|3617178|30|NZ_CP045929|CRISPRCasFinder matches to position: 3814876-3814905, mismatch: 2, identity: 0.933

cgaggcgaacggcactttcgccccaccaca	CRISPR spacer
cggggcgaacggcactttcgcctcaccaca	Protospacer
**.*******************.*******

12. spacer 7.1|3617178|30|NZ_CP045929|CRISPRCasFinder matches to position: 303245-303274, mismatch: 2, identity: 0.933

cgaggcgaacggcactttcgccccaccaca	CRISPR spacer
cgaggcgaacggcactttcgcctcagcaca	Protospacer
**********************.** ****

13. spacer 7.1|3617178|30|NZ_CP045929|CRISPRCasFinder matches to position: 549104-549133, mismatch: 2, identity: 0.933

cgaggcgaacggcactttcgccccaccaca	CRISPR spacer
cggggcgaacggcactttcgcctcaccaca	Protospacer
**.*******************.*******

14. spacer 7.1|3617178|30|NZ_CP045929|CRISPRCasFinder matches to position: 3979713-3979742, mismatch: 2, identity: 0.933

cgaggcgaacggcactttcgccccaccaca	CRISPR spacer
cggggcgaacggcacgttcgccccaccaca	Protospacer
**.************ **************

15. spacer 7.1|3617178|30|NZ_CP045929|CRISPRCasFinder matches to position: 4084786-4084815, mismatch: 2, identity: 0.933

cgaggcgaacggcactttcgccccaccaca	CRISPR spacer
cgaggcgaacggcactctcgccccacaaca	Protospacer
****************.********* ***

16. spacer 7.1|3617178|30|NZ_CP045929|CRISPRCasFinder matches to position: 4096956-4096985, mismatch: 2, identity: 0.933

cgaggcgaacggcactttcgccccaccaca	CRISPR spacer
cgaagcgaacggcactctcgccccaccaca	Protospacer
***.************.*************

17. spacer 7.1|3617178|30|NZ_CP045929|CRISPRCasFinder matches to position: 4107783-4107812, mismatch: 2, identity: 0.933

cgaggcgaacggcactttcgccccaccaca	CRISPR spacer
cggggcgaacggcactttcgcctcaccaca	Protospacer
**.*******************.*******

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP045929_7	7.2\|3617238\|27\|NZ_CP045929\|CRISPRCasFinder	3617238-3617264	27	NZ_CP020900	Rhizobium phaseoli Brasil 5 strain Bra5 plasmid pRphaBra5d, complete sequence	674462-674488	5	0.815
NZ_CP045929_7	7.2\|3617238\|27\|NZ_CP045929\|CRISPRCasFinder	3617238-3617264	27	NZ_CP013526	Rhizobium phaseoli strain R744 plasmid pRphaR744d, complete sequence	921636-921662	5	0.815
NZ_CP045929_7	7.2\|3617238\|27\|NZ_CP045929\|CRISPRCasFinder	3617238-3617264	27	NZ_CP024312	Rhizobium sp. NXC24 plasmid pRspNXC24a, complete sequence	80949-80975	5	0.815
NZ_CP045929_7	7.1\|3617178\|30\|NZ_CP045929\|CRISPRCasFinder	3617178-3617207	30	NZ_CP016453	Sphingobium sp. RAC03 plasmid pBSY17_1, complete sequence	558087-558116	10	0.667

1. spacer 7.2|3617238|27|NZ_CP045929|CRISPRCasFinder matches to NZ_CP020900 (Rhizobium phaseoli Brasil 5 strain Bra5 plasmid pRphaBra5d, complete sequence) position: , mismatch: 5, identity: 0.815

gcggctggagacctccgcctactggga	CRISPR spacer
ggcgctggagtccgccgcctactgggc	Protospacer
*  ******* ** ************

2. spacer 7.2|3617238|27|NZ_CP045929|CRISPRCasFinder matches to NZ_CP013526 (Rhizobium phaseoli strain R744 plasmid pRphaR744d, complete sequence) position: , mismatch: 5, identity: 0.815

gcggctggagacctccgcctactggga	CRISPR spacer
ggcgctggagtccgccgcctactgggc	Protospacer
*  ******* ** ************

3. spacer 7.2|3617238|27|NZ_CP045929|CRISPRCasFinder matches to NZ_CP024312 (Rhizobium sp. NXC24 plasmid pRspNXC24a, complete sequence) position: , mismatch: 5, identity: 0.815

gcggctggagacctccgcctactggga	CRISPR spacer
ggcgctggagtccgccgcctactgggc	Protospacer
*  ******* ** ************

4. spacer 7.1|3617178|30|NZ_CP045929|CRISPRCasFinder matches to NZ_CP016453 (Sphingobium sp. RAC03 plasmid pBSY17_1, complete sequence) position: , mismatch: 10, identity: 0.667

cgaggcgaacggcactttcgccccaccaca	CRISPR spacer
cgaggcgatcggcactttcgcggtcgagag	Protospacer
******** ************  .   . .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

813842 : 855989

Emiliania_huxleyi_virus(11.11%)

protease,transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_154078591.1\|813842_814601_-\|protease	trypsin-like serine protease	G8DFY0	Emiliania_huxleyi_virus	6.5e-18	32.3
WP_154078592.1\|814853_815825_+	FAD-dependent oxidoreductase	Q9JRK7	Streptococcus_phage	1.4e-12	34.6
WP_154075407.1\|815923_816664_-\|protease	trypsin-like serine protease	NA	NA	NA	NA
WP_154078593.1\|816871_817840_-	class II fructose-bisphosphatase	NA	NA	NA	NA
WP_154075408.1\|818250_818553_-	exodeoxyribonuclease VII small subunit	NA	NA	NA	NA
WP_154075409.1\|819086_820331_-	exodeoxyribonuclease VII large subunit	A0A1B3AYB4	Gordonia_phage	3.5e-69	49.7
WP_154075410.1\|820448_820931_-	lipid droplet-associated protein	NA	NA	NA	NA
WP_154075411.1\|821058_822078_+	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	NA	NA	NA	NA
WP_154075412.1\|822336_823494_-	hypothetical protein	NA	NA	NA	NA
WP_154075413.1\|823712_825260_+	ATP-binding cassette domain-containing protein	G3M9Y6	Bacillus_virus	5.8e-13	26.4
WP_154075414.1\|825256_826300_+	ABC transporter permease	NA	NA	NA	NA
WP_154075415.1\|826328_827339_+	substrate-binding domain-containing protein	NA	NA	NA	NA
WP_154078594.1\|829043_831515_+	DUF2961 domain-containing protein	NA	NA	NA	NA
WP_154075416.1\|831656_832658_-	substrate-binding domain-containing protein	NA	NA	NA	NA
WP_154075417.1\|832850_834269_+	fucose isomerase	NA	NA	NA	NA
WP_154075418.1\|834323_835817_+	sugar kinase	NA	NA	NA	NA
WP_154075419.1\|835936_836869_-	DNA recombination protein RmuC	NA	NA	NA	NA
WP_154075420.1\|837179_837749_+\|transposase	IS607 family transposase	F9VHY9	Thermus_phage	1.2e-21	37.3
WP_154075421.1\|837745_839116_+\|transposase	transposase	A0A0R8V9X2	Thermobifida_phage	5.6e-44	36.1
WP_154075422.1\|839235_839697_+	hypothetical protein	NA	NA	NA	NA
WP_154075423.1\|839830_841012_+	exonuclease subunit SbcD	NA	NA	NA	NA
WP_154075424.1\|841008_843963_+	AAA family ATPase	NA	NA	NA	NA
WP_154075425.1\|844159_844660_-	methylated-DNA--[protein]-cysteine S-methyltransferase	NA	NA	NA	NA
WP_154075426.1\|844656_846123_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_154075427.1\|846292_846520_+	hypothetical protein	NA	NA	NA	NA
WP_154075428.1\|846613_847693_+	redox-regulated ATPase YchF	NA	NA	NA	NA
WP_154075429.1\|847713_847914_-	hypothetical protein	NA	NA	NA	NA
WP_154075430.1\|848156_849686_+	Abi family protein	A3QSC6	Clostridium_virus	1.8e-27	30.9
WP_154075431.1\|849925_851872_-	BCCT family transporter	A0A2I7QNT1	Vibrio_phage	5.7e-18	25.1
WP_154075432.1\|852033_852594_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_154075433.1\|853695_854985_-\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	4.0e-177	72.4
WP_154075434.1\|855212_855989_-\|transposase	IS5 family transposase	NA	NA	NA	NA

DBSCAN-SWA_2

1000627 : 1061072

Bacillus_phage(16.67%)

transposase,protease,integrase

attL 1053606:1053665|attR 1062765:1064065

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_154075534.1\|1000627_1001635_-\|protease	metalloprotease	NA	NA	NA	NA
WP_154075535.1\|1001706_1003395_+	DUF2207 domain-containing protein	NA	NA	NA	NA
WP_154075536.1\|1003457_1004777_+	insulinase family protein	NA	NA	NA	NA
WP_154075537.1\|1004773_1006138_+	insulinase family protein	NA	NA	NA	NA
WP_154075538.1\|1006469_1007393_+	NAD(+) diphosphatase	NA	NA	NA	NA
WP_154075539.1\|1007610_1007931_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_154075540.1\|1008494_1010597_+	AAA family ATPase	S5M596	Bacillus_phage	1.4e-49	27.7
WP_154075541.1\|1010757_1010931_+	hypothetical protein	NA	NA	NA	NA
WP_154075542.1\|1011048_1011399_+	WhiB family transcriptional regulator	G1FTY2	Mycobacterium_phage	1.6e-08	44.4
WP_154075543.1\|1011395_1011620_+	hypothetical protein	NA	NA	NA	NA
WP_154078620.1\|1011749_1012598_+	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_154075544.1\|1012795_1014109_-	phosphotransferase	A0A0R6PEF3	Moraxella_phage	5.6e-25	32.8
WP_154075545.1\|1014728_1015265_+	DUF45 domain-containing protein	NA	NA	NA	NA
WP_154075546.1\|1015892_1017395_-\|protease	zinc-dependent metalloprotease	NA	NA	NA	NA
WP_154075547.1\|1017569_1018595_+	PDZ domain-containing protein	NA	NA	NA	NA
WP_154075548.1\|1018821_1019364_-	hypothetical protein	NA	NA	NA	NA
WP_154075549.1\|1019574_1022502_+	membrane protein	NA	NA	NA	NA
WP_154075550.1\|1022732_1023167_+	hypothetical protein	NA	NA	NA	NA
WP_154075551.1\|1023641_1024139_+	PadR family transcriptional regulator	NA	NA	NA	NA
WP_154075552.1\|1024209_1025316_+	peptide chain release factor 2	NA	NA	NA	NA
WP_154075553.1\|1025428_1026118_+	cell division ATP-binding protein FtsE	G9BWD6	Planktothrix_phage	2.9e-25	33.8
WP_154075554.1\|1026164_1027067_+	FtsX-like permease family protein	NA	NA	NA	NA
WP_154075555.1\|1027172_1027649_+	SsrA-binding protein SmpB	W5RAM5	Staphylococcus_phage	3.1e-34	49.3
WP_154075556.1\|1027650_1028553_+	amidohydrolase family protein	NA	NA	NA	NA
WP_154075557.1\|1028622_1029486_+	EamA family transporter	NA	NA	NA	NA
WP_154075558.1\|1030098_1030395_+	hypothetical protein	NA	NA	NA	NA
WP_154075559.1\|1030437_1031361_-	hypothetical protein	NA	NA	NA	NA
WP_154075560.1\|1031535_1031949_+	DUF1232 domain-containing protein	NA	NA	NA	NA
WP_154075561.1\|1032035_1032434_+	6-carboxytetrahydropterin synthase	NA	NA	NA	NA
WP_154075562.1\|1032406_1033489_+	glycosyltransferase	NA	NA	NA	NA
WP_154075563.1\|1033485_1034280_+	SAM-dependent methyltransferase	NA	NA	NA	NA
WP_154075564.1\|1034285_1035203_+	UPF0104 family protein	NA	NA	NA	NA
WP_154075565.1\|1035181_1036111_-	pseudouridylate synthase	NA	NA	NA	NA
WP_154075566.1\|1036331_1037339_-	transcriptional regulator	NA	NA	NA	NA
WP_154075567.1\|1037564_1038818_-	S8 family serine peptidase	A0A2K9L199	Tupanvirus	5.7e-35	38.6
WP_154078621.1\|1039311_1040142_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_154075568.1\|1040264_1041653_+	MFS transporter	NA	NA	NA	NA
WP_154075569.1\|1041756_1041993_+	hypothetical protein	NA	NA	NA	NA
WP_154075570.1\|1041979_1043308_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_154078622.1\|1043309_1044647_-	AMP-binding protein	NA	NA	NA	NA
WP_154078623.1\|1044925_1045888_-\|integrase	tyrosine-type recombinase/integrase	A0A2H4JCB7	uncultured_Caudovirales_phage	4.8e-34	30.8
WP_154075571.1\|1046088_1046277_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_154075572.1\|1046312_1047851_-	hypothetical protein	NA	NA	NA	NA
WP_154075573.1\|1047847_1048030_-	hypothetical protein	NA	NA	NA	NA
WP_154075574.1\|1048035_1048314_-	hypothetical protein	NA	NA	NA	NA
WP_154075575.1\|1048372_1049197_-	cell division protein FtsK	A0A219UQY0	Bacillus_phage	2.2e-11	30.0
WP_154078624.1\|1049186_1049924_-	hypothetical protein	NA	NA	NA	NA
WP_154075576.1\|1050088_1050277_-	hypothetical protein	NA	NA	NA	NA
WP_154075577.1\|1050276_1050552_-	hypothetical protein	NA	NA	NA	NA
WP_154075578.1\|1050589_1050931_-	hypothetical protein	NA	NA	NA	NA
WP_154075579.1\|1051042_1051612_-	flavoprotein	NA	NA	NA	NA
WP_154075580.1\|1051608_1052847_-	helix-turn-helix domain-containing protein	A0A291LGX8	Streptomyces_phage	6.9e-25	28.2
1053606:1053665	attL	NA	NA	NA	NA
WP_154075325.1\|1053648_1054784_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	6.7e-43	36.7
WP_154075581.1\|1055379_1055841_-	hypothetical protein	NA	NA	NA	NA
WP_154078625.1\|1055986_1056823_-	hypothetical protein	NA	NA	NA	NA
WP_154078626.1\|1057238_1057484_-	hypothetical protein	NA	NA	NA	NA
WP_154075582.1\|1057513_1057846_-	hypothetical protein	NA	NA	NA	NA
WP_154075583.1\|1058629_1059796_-\|integrase	tyrosine-type recombinase/integrase	G8IR34	Mycobacterium_virus	4.2e-16	26.7
WP_154075584.1\|1059904_1061072_+\|transposase	IS3 family transposase	U5P429	Shigella_phage	2.3e-38	38.8
1062765:1064065	attR	NA	NA	NA	NA

DBSCAN-SWA_3

1437982 : 1463253

Shigella_phage(33.33%)

tRNA,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_154078666.1\|1437982_1439368_+\|tRNA	glycine--tRNA ligase	A0A1V0SIF1	Klosneuvirus	1.6e-51	27.4
WP_154078667.1\|1439537_1440134_+	YdcF family protein	NA	NA	NA	NA
WP_154075896.1\|1440386_1441673_+	deoxyguanosinetriphosphate triphosphohydrolase	NA	NA	NA	NA
WP_154075897.1\|1441832_1442018_+	hypothetical protein	NA	NA	NA	NA
WP_154075898.1\|1442107_1443211_+	serpin family protein	B2CWQ7	Myxoma_virus	5.7e-15	26.6
WP_154075899.1\|1443304_1443871_+	carboxymuconolactone decarboxylase family protein	NA	NA	NA	NA
WP_154075900.1\|1444062_1445019_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_154075901.1\|1445078_1446977_+	DNA primase	B8Q5B5	Abalone_shriveling_syndrome-associated_virus	4.3e-34	29.9
WP_154075902.1\|1446973_1447513_+	hypothetical protein	NA	NA	NA	NA
WP_154075903.1\|1447559_1448324_+	trans-aconitate 2-methyltransferase	NA	NA	NA	NA
WP_154075433.1\|1448761_1450051_-\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	4.0e-177	72.4
WP_154075904.1\|1450305_1450512_+	hypothetical protein	NA	NA	NA	NA
WP_154075434.1\|1450834_1451611_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_154075905.1\|1452123_1453404_+	DUF418 domain-containing protein	NA	NA	NA	NA
WP_154075906.1\|1453429_1453690_-	hypothetical protein	NA	NA	NA	NA
WP_154078668.1\|1453816_1455028_+	amino acid permease	NA	NA	NA	NA
WP_154075907.1\|1455272_1456733_-	catalase	A0A2K9L572	Tupanvirus	5.5e-82	39.6
WP_154078669.1\|1457432_1458419_-\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	2.9e-34	32.6
WP_154075908.1\|1458603_1459739_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	1.5e-42	36.7
WP_154075909.1\|1459970_1460207_+	CopG family transcriptional regulator	NA	NA	NA	NA
WP_154075910.1\|1460305_1460689_-	protein-tyrosine-phosphatase	NA	NA	NA	NA
WP_154075584.1\|1460774_1461942_+\|transposase	IS3 family transposase	U5P429	Shigella_phage	2.3e-38	38.8
WP_154075908.1\|1462118_1463253_+\|transposase	IS3 family transposase	U5P429	Shigella_phage	1.5e-42	36.7

DBSCAN-SWA_4

2592609 : 2648727

uncultured_virus(25.0%)

tRNA,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_154076786.1\|2592609_2593424_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_154076787.1\|2593992_2594457_-	glyoxalase/bleomycin resistance/dioxygenase family protein	NA	NA	NA	NA
WP_154076788.1\|2594613_2594994_+	arsenite efflux transporter metallochaperone ArsD	NA	NA	NA	NA
WP_154076789.1\|2596864_2597227_+	metalloregulator ArsR/SmtB family transcription factor	A0A218MNF3	uncultured_virus	3.1e-10	47.0
WP_154078801.1\|2597423_2598482_+	ACR3 family arsenite efflux transporter	NA	NA	NA	NA
WP_154076790.1\|2598569_2599121_+	arsenate reductase ArsC	NA	NA	NA	NA
WP_154076791.1\|2599338_2599521_-	hypothetical protein	NA	NA	NA	NA
WP_154076792.1\|2600966_2601953_+	2,3-diaminopropionate biosynthesis protein SbnA	A0A1W6JHY1	Lactococcus_phage	2.7e-40	32.5
WP_154076793.1\|2601949_2604484_+	MFS transporter	NA	NA	NA	NA
WP_154076794.1\|2604903_2606217_+	aminotransferase class V-fold PLP-dependent enzyme	NA	NA	NA	NA
WP_154076795.1\|2606278_2606641_+	hypothetical protein	NA	NA	NA	NA
WP_154076796.1\|2606741_2607818_+	SidA/IucD/PvdA family monooxygenase	A0A2H4J2Q2	uncultured_Caudovirales_phage	2.4e-13	28.2
WP_154078802.1\|2608129_2608942_-	peptidoglycan DD-metalloendopeptidase family protein	A0A2D1G842	Mycobacterium_phage	3.6e-22	51.7
WP_154076797.1\|2609698_2611123_-	NADH-quinone oxidoreductase subunit NuoN	NA	NA	NA	NA
WP_154076798.1\|2611119_2612625_-	NADH-quinone oxidoreductase subunit M	NA	NA	NA	NA
WP_154076799.1\|2612628_2614500_-	NADH-quinone oxidoreductase subunit L	NA	NA	NA	NA
WP_154076800.1\|2614503_2614809_-	NADH-quinone oxidoreductase subunit NuoK	NA	NA	NA	NA
WP_154076801.1\|2614805_2615369_-	NADH:ubiquinone oxidoreductase subunit J	NA	NA	NA	NA
WP_154076802.1\|2615379_2616303_-	NADH-quinone oxidoreductase subunit H	NA	NA	NA	NA
WP_154076803.1\|2616295_2617522_-	hypothetical protein	NA	NA	NA	NA
WP_154076804.1\|2617512_2617863_-	NADH-quinone oxidoreductase subunit A	NA	NA	NA	NA
WP_154076805.1\|2618278_2618560_+	metal-sensing transcriptional repressor	NA	NA	NA	NA
WP_154076806.1\|2618602_2618812_+	cation-transporting ATPase	NA	NA	NA	NA
WP_154076807.1\|2618993_2621321_+	heavy metal translocating P-type ATPase	A0A218MNH6	uncultured_virus	1.0e-85	32.8
WP_154076808.1\|2621665_2622298_-	DUF305 domain-containing protein	NA	NA	NA	NA
WP_154076809.1\|2622383_2622815_-	hypothetical protein	NA	NA	NA	NA
WP_154076810.1\|2622901_2623813_-\|transposase	IS3 family transposase	A0A1P8CWQ3	Bacillus_phage	6.6e-25	30.7
WP_154076811.1\|2623809_2624127_-\|transposase	transposase	NA	NA	NA	NA
WP_154076812.1\|2624448_2625765_-	MFS transporter	NA	NA	NA	NA
WP_154078803.1\|2625761_2626745_-	2,3-diaminopropionate biosynthesis protein SbnA	A0A1W6JHY1	Lactococcus_phage	8.7e-39	31.9
WP_154076813.1\|2628219_2629260_+	hydrolase	A0A1J0GW44	Streptomyces_phage	1.8e-18	41.7
WP_154076814.1\|2629657_2630575_+	exo-alpha-sialidase	NA	NA	NA	NA
WP_154076815.1\|2630651_2631011_+	BlaI/MecI/CopY family transcriptional regulator	NA	NA	NA	NA
WP_154076816.1\|2631007_2631964_+	hypothetical protein	NA	NA	NA	NA
WP_154078804.1\|2632057_2633566_-	multicopper oxidase domain-containing protein	NA	NA	NA	NA
WP_154076817.1\|2634249_2635017_-	hypothetical protein	NA	NA	NA	NA
WP_154076818.1\|2635282_2636242_-	diacylglyceryl transferase	NA	NA	NA	NA
WP_154076819.1\|2636972_2637923_-\|protease	M48 family metalloprotease	NA	NA	NA	NA
WP_154076820.1\|2637919_2638291_-	BlaI/MecI/CopY family transcriptional regulator	NA	NA	NA	NA
WP_154076821.1\|2638852_2639533_+	DUF3105 domain-containing protein	NA	NA	NA	NA
WP_154078805.1\|2639570_2640251_+	DUF305 domain-containing protein	NA	NA	NA	NA
WP_154076822.1\|2640269_2640941_+	redoxin family protein	NA	NA	NA	NA
WP_154076823.1\|2641067_2641505_-	DUF2933 domain-containing protein	NA	NA	NA	NA
WP_154076824.1\|2641401_2641608_-	hypothetical protein	NA	NA	NA	NA
WP_154076825.1\|2641937_2642729_-\|tRNA	tRNA-dependent cyclodipeptide synthase	NA	NA	NA	NA
WP_154076826.1\|2642911_2643862_-\|protease	M48 family metalloprotease	NA	NA	NA	NA
WP_154076827.1\|2643858_2644194_-	BlaI/MecI/CopY family transcriptional regulator	NA	NA	NA	NA
WP_154076828.1\|2644455_2644854_+	metal-sensing transcriptional repressor	NA	NA	NA	NA
WP_154076829.1\|2644840_2645074_+	SHOCT domain-containing protein	NA	NA	NA	NA
WP_154076830.1\|2645192_2646824_+	multicopper oxidase domain-containing protein	NA	NA	NA	NA
WP_154076831.1\|2646892_2647465_+	hypothetical protein	NA	NA	NA	NA
WP_154076832.1\|2647507_2647876_+	BlaI/MecI/CopY family transcriptional regulator	NA	NA	NA	NA
WP_154076833.1\|2647872_2648727_+\|protease	M48 family metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_5

2660255 : 2691019

Streptococcus_phage(37.5%)

integrase,protease,transposase

attL 2665013:2665027|attR 2680364:2680378

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_154078809.1\|2660255_2661536_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	3.9e-39	42.7
WP_154076846.1\|2663065_2663704_-	Vitamin K epoxide reductase	NA	NA	NA	NA
WP_154076847.1\|2663714_2664383_-	thioredoxin domain-containing protein	NA	NA	NA	NA
WP_154076848.1\|2664435_2665371_-\|protease	M48 family metalloprotease	NA	NA	NA	NA
2665013:2665027	attL	NA	NA	NA	NA
WP_154076849.1\|2665367_2665742_-	BlaI/MecI/CopY family transcriptional regulator	NA	NA	NA	NA
WP_154076850.1\|2665797_2666364_-	copper resistance protein CopC	NA	NA	NA	NA
WP_154076851.1\|2666525_2668529_+	copper resistance protein CopD	NA	NA	NA	NA
WP_154076852.1\|2668635_2669037_+	metalloregulator ArsR/SmtB family transcription factor	NA	NA	NA	NA
WP_154076853.1\|2669040_2671056_+	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	6.0e-103	38.1
WP_154076854.1\|2671101_2672517_+	mercury(II) reductase	A0A2K5B2C5	Erysipelothrix_phage	2.3e-53	29.8
WP_154076855.1\|2672759_2673362_-	GTP cyclohydrolase I FolE	R4TN89	Halovirus	1.5e-38	44.6
WP_154076856.1\|2673406_2673829_-	hypothetical protein	NA	NA	NA	NA
WP_154076857.1\|2673890_2674424_-	DUF2231 domain-containing protein	NA	NA	NA	NA
WP_154076858.1\|2674550_2675267_+	transcriptional regulator	NA	NA	NA	NA
WP_154076859.1\|2675432_2677838_-	heavy metal translocating P-type ATPase	E4ZFI9	Streptococcus_phage	5.7e-68	31.9
WP_154076860.1\|2678030_2679011_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_154076861.1\|2679017_2679632_-	isoprenylcysteine carboxylmethyltransferase family protein	NA	NA	NA	NA
WP_154076862.1\|2679635_2680139_-	signal peptidase II	NA	NA	NA	NA
WP_154076863.1\|2680135_2682106_-	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	5.3e-104	39.1
2680364:2680378	attR	NA	NA	NA	NA
WP_154076864.1\|2682102_2682501_-	metalloregulator ArsR/SmtB family transcription factor	NA	NA	NA	NA
WP_154078810.1\|2682551_2683163_+	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_154076865.1\|2683185_2686272_-\|transposase	Tn3 family transposase	Q1MVP5	Enterobacteria_phage	1.6e-208	40.6
WP_154078811.1\|2686483_2686705_-	copper chaperone	NA	NA	NA	NA
WP_154078812.1\|2686818_2687262_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_154078813.1\|2687305_2687638_-	four-helix bundle copper-binding protein	NA	NA	NA	NA
WP_154078814.1\|2688260_2689523_-\|transposase	IS256 family transposase	NA	NA	NA	NA
WP_154078815.1\|2689738_2691019_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	1.7e-39	43.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP045929

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection