CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Prophage number
NZ_CP046102	Rhodococcus sp. AQ5-07 plasmid unnamed3, complete sequence	0 crisprs	NA	0
NZ_CP046101	Rhodococcus sp. AQ5-07 plasmid unnamed2, complete sequence	0 crisprs	csa3	0
NZ_CP046100	Rhodococcus sp. AQ5-07 plasmid unnamed1, complete sequence	0 crisprs	PD-DExK,csa3	0
NZ_CP046099	Rhodococcus sp. AQ5-07 chromosome, complete genome	2 crisprs	cas3,csa3,WYL,cas4,DEDDh,DinG,Cas9_archaeal,RT	2

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP046099_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046099_1

729876-729961

Orphan

Consensus_repeat	Method
CACCGGATGCTGCGCCGCCGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046099_1

>merge|NZ_CP046099|1|729876-729961|CRISPRCasFinder
CACCGGATGCTGCGCCGCCGCCGGCGCCGCCGCGCTTGCGTGCCTTCGGCTTCTTGCGGATGGCACCGGATGCTGCGCCGCCGCCG

>NZ_CP046099|1|1|729876-729961|CRISPRCasFinder
CACCGGATGCTGCGCCGCCGCCG	GCGCCGCCGCGCTTGCGTGCCTTCGGCTTCTTGCGGATGG
CACCGGATGCTGCGCCGCCGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046099.1\|WP_019747745.1\|733008_733425_-\|SufE-family-protein	unknown	unknown	gnl\|CDD\|376883
NZ_CP046099.1\|WP_019747746.1\|733421_734327_-\|sulfurtransferase	unknown	unknown	gnl\|CDD\|225450
NZ_CP046099.1\|WP_113683011.1\|739312_740617_+\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|367155
NZ_CP046099.1\|WP_113683105.1\|724344_725715_-\|8-oxoguanine-deaminase	unknown	unknown	gnl\|CDD\|236184
NZ_CP046099.1\|WP_113683017.1\|726693_727023_-\|hydroxyisourate-hydrolase	unknown	unknown	gnl\|CDD\|376352
NZ_CP046099.1\|WP_113683015.1\|728455_728818_-\|VanZ-family-protein	unknown	unknown	gnl\|CDD\|227939
NZ_CP046099.1\|WP_113683019.1\|720819_723531_-\|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|182084
NZ_CP046099.1\|WP_060938607.1\|734445_735909_-\|condensation-protein	unknown	unknown	gnl\|CDD\|334202
NZ_CP046099.1\|WP_007731146.1\|740741_741383_-\|septum-formation-inhibitor-Maf	unknown	unknown	gnl\|CDD\|178901
NZ_CP046099.1\|WP_060938629.1\|723527_724337_-\|FAD-binding-molybdopterin-dehydrogenase	unknown	unknown	gnl\|CDD\|366378
NZ_CP046099.1\|WP_029255030.1\|727654_728455_+\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|379135
NZ_CP046099.1\|WP_020907074.1\|729164_729590_-\|DUF1707-domain-containing-protein	unknown	unknown	gnl\|CDD\|377959
NZ_CP046099.1\|WP_113683012.1\|737552_739250_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP046099.1\|WP_003940853.1\|741736_743377_-\|acyl-CoA-carboxylase-subunit-beta	unknown	unknown	gnl\|CDD\|227136
NZ_CP046099.1\|WP_113683014.1\|731601_733002_-\|condensation-protein	unknown	unknown	gnl\|CDD\|334202
NZ_CP046099.1\|WP_003940792.1\|728814_729165_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046099.1\|WP_113683013.1\|735908_737402_-\|acyltransferase	unknown	unknown	gnl\|CDD\|334202
NZ_CP046099.1\|WP_113683018.1\|725711_726689_-\|urate-oxidase	unknown	unknown	gnl\|CDD\|274554
NZ_CP046099.1\|WP_019747751.1\|741398_741740_-\|acyl-CoA-carboxylase-subunit-epsilon	unknown	unknown	gnl\|CDD\|379386
NZ_CP046099.1\|WP_113683016.1\|727019_727538_-\|2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline-decarboxylase	unknown	unknown	gnl\|CDD\|184333

Protein	Function_ID	Function_description	E-value
NZ_CP046099.1\|WP_019747745.1\|733008_733425_-\|SufE-family-protein	gnl\|CDD\|376883	pfam02657, SufE, Fe-S metabolism associated domain. This family consists of the SufE-related proteins. These have been implicated in Fe-S metabolism and export).	1.79337e-42
NZ_CP046099.1\|WP_019747746.1\|733421_734327_-\|sulfurtransferase	gnl\|CDD\|225450	COG2897, SseA, Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism].	2.07893e-99
NZ_CP046099.1\|WP_113683011.1\|739312_740617_+\|HNH-endonuclease	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	2.27324e-34
NZ_CP046099.1\|WP_113683105.1\|724344_725715_-\|8-oxoguanine-deaminase	gnl\|CDD\|236184	PRK08203, PRK08203, hydroxydechloroatrazine ethylaminohydrolase; Reviewed.	0
NZ_CP046099.1\|WP_113683017.1\|726693_727023_-\|hydroxyisourate-hydrolase	gnl\|CDD\|376352	pfam00576, Transthyretin, HIUase/Transthyretin family. This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of the purine catabolism that catalyze the conversion of 5-hydroxyisourate (HIU) to OHCU. HIU hydrolysis is the original function of the family and is conserved from bacteria to mammals; transthyretins arose by gene duplications in the vertebrate lineage. HIUases are distinguished in the alignment from the conserved C-terminal YRGS sequence.	9.58181e-48
NZ_CP046099.1\|WP_113683015.1\|728455_728818_-\|VanZ-family-protein	gnl\|CDD\|227939	COG5652, COG5652, Predicted integral membrane protein [Function unknown].	0.00017429
NZ_CP046099.1\|WP_113683019.1\|720819_723531_-\|molybdopterin-dependent-oxidoreductase	gnl\|CDD\|182084	PRK09800, PRK09800, putative hypoxanthine oxidase; Provisional.	8.37023e-170
NZ_CP046099.1\|WP_060938607.1\|734445_735909_-\|condensation-protein	gnl\|CDD\|334202	pfam00668, Condensation, Condensation domain. This domain is found in many multi-domain enzymes which synthesize peptide antibiotics. This domain catalyzes a condensation reaction to form peptide bonds in non- ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pfam00550). It has been shown that mutations in the HHXXXDG motif abolish activity suggesting this is part of the active site.	6.08233e-15
NZ_CP046099.1\|WP_007731146.1\|740741_741383_-\|septum-formation-inhibitor-Maf	gnl\|CDD\|178901	PRK00148, PRK00148, Maf-like protein; Reviewed.	2.78195e-103
NZ_CP046099.1\|WP_060938629.1\|723527_724337_-\|FAD-binding-molybdopterin-dehydrogenase	gnl\|CDD\|366378	pfam00941, FAD_binding_5, FAD binding domain in molybdopterin dehydrogenase.	1.74682e-14
NZ_CP046099.1\|WP_029255030.1\|727654_728455_+\|tyrosine-protein-phosphatase	gnl\|CDD\|379135	pfam13350, Y_phosphatase3, Tyrosine phosphatase family. This family is closely related to the pfam00102 and pfam00782 families.	1.84599e-76
NZ_CP046099.1\|WP_020907074.1\|729164_729590_-\|DUF1707-domain-containing-protein	gnl\|CDD\|377959	pfam08044, DUF1707, Domain of unknown function (DUF1707). This domain is found in a variety of Actinomycetales proteins. All of the proteins containing this domain are hypothetical and probably membrane bound or associated. Currently, it is unclear to the function of this domain.	1.57117e-20
NZ_CP046099.1\|WP_113683012.1\|737552_739250_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	4.96657e-62
NZ_CP046099.1\|WP_003940853.1\|741736_743377_-\|acyl-CoA-carboxylase-subunit-beta	gnl\|CDD\|227136	COG4799, COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism].	0
NZ_CP046099.1\|WP_113683014.1\|731601_733002_-\|condensation-protein	gnl\|CDD\|334202	pfam00668, Condensation, Condensation domain. This domain is found in many multi-domain enzymes which synthesize peptide antibiotics. This domain catalyzes a condensation reaction to form peptide bonds in non- ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pfam00550). It has been shown that mutations in the HHXXXDG motif abolish activity suggesting this is part of the active site.	6.7506e-20
NZ_CP046099.1\|WP_113683013.1\|735908_737402_-\|acyltransferase	gnl\|CDD\|334202	pfam00668, Condensation, Condensation domain. This domain is found in many multi-domain enzymes which synthesize peptide antibiotics. This domain catalyzes a condensation reaction to form peptide bonds in non- ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pfam00550). It has been shown that mutations in the HHXXXDG motif abolish activity suggesting this is part of the active site.	1.43871e-17
NZ_CP046099.1\|WP_113683018.1\|725711_726689_-\|urate-oxidase	gnl\|CDD\|274554	TIGR03383, Structure_Of_Uricase, urate oxidase. Members of this protein family are urate oxidase, also called uricase. This protein contains two copies of the domain described by the uricase model pfam01014. In animals, this enzyme has been lost from primates and birds. [Central intermediary metabolism, Other].	2.42891e-134
NZ_CP046099.1\|WP_019747751.1\|741398_741740_-\|acyl-CoA-carboxylase-subunit-epsilon	gnl\|CDD\|379386	pfam13822, ACC_epsilon, Acyl-CoA carboxylase epsilon subunit. This family includes the epsilon subunits of propionyl-CoA carboxylase, EC:6.4.1.3, and acetyl-CoA carboxylase, EC:6.4.1.2. These enzymes are involved in the biosynthesis of long-chain fatty acids. The epsilon subunit is necessary for an efficient interaction between the alpha and beta subunits of these enzymes.	1.60453e-11
NZ_CP046099.1\|WP_113683016.1\|727019_727538_-\|2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline-decarboxylase	gnl\|CDD\|184333	PRK13798, PRK13798, putative OHCU decarboxylase; Provisional.	1.52267e-66

>NZ_CP046099.1|WP_020907074.1|729164_729590_-|DUF1707-domain-containing-protein
MADVPDIRIGTAEREQALDLLSEHFAAGRLTVTEFDERSGIVSAATTRSELVPVFADLPGNYQAPGTAPLSMVTPPAAPAERRFNPDWSGRVMAVIPILAVILFFVTGTWLWFLAIPLAGALLFGTDRERKAKRRRERDSD
>NZ_CP046099.1|WP_003940792.1|728814_729165_-|hypothetical-protein
MEPIEINAGGWYLRALRADERVDDRPALADGGITDPDYVSQRSAQWHENSVYSWAVCQPNTGELLAEVVLTPLDSTALLTGWARDGHTEALTTAADAVTRFAEGALGLVVVEGQTN
>NZ_CP046099.1|WP_113683015.1|728455_728818_-|VanZ-family-protein
MKNNRYWPLAIAVVIALIMLFSPGSTVPSSPENTDKITHTLMFAVLAITSLHARIPAWITAVWLVIFAATSEVLQAALPISRSGSIWDGTADLLGIAIGIGIVSLVMRRRRARDDEPSRS
>NZ_CP046099.1|WP_029255030.1|727654_728455_+|tyrosine-protein-phosphatase
MTDTPKLSSVVPSLANLRDIGGPESSFGGTVRTGSVFRSTDLASLSAEGAQTLADLGIVTIYDLRTESERETAPDLTPDGIRELGLDVLADKQYRAIPAQMQQMIADPAFAAEALGGGQALEYFQGSYRDFVTLPSAVASYRQLFVDLAQPPSSPALIHCTTGKDRTGWAAAALLLFLGASEDAVFADYLETNKVLLPMFAPLLERFEAKGIDPTLLEGVLGVRREYLEASMAELAQVHGSIEAYFTDGLKIDASTQEQLRSNLLS
>NZ_CP046099.1|WP_113683016.1|727019_727538_-|2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline-decarboxylase
MPTTNSSGLGAFDALGDHQAVAALLECCHSAVWAQEIAASRPFTDLEALFDKADAVLAELPESEIDDALSGHPRIGERSESAASTREQSEVSSATEDVLAELRQKNAEYEETFGHVYLVCASGKSGTELLDILRGRLRNDPATERSVLRTELAAINRIRLARLIDSLAGGAA
>NZ_CP046099.1|WP_113683017.1|726693_727023_-|hydroxyisourate-hydrolase
MSKTLSTHVLDATTGIPAAGIRVELRDRDGVTITSAETDSDGRIPELAPGGLVTGHYTLTFDTGTYFETNGQENFYPEVTVTFRVDDTTRGYHVPLLLSPFAYSTYRGS
>NZ_CP046099.1|WP_113683018.1|725711_726689_-|urate-oxidase
MTTENITTGNITTGVTSTDRLSGSIELTGHQYGKAENRVVRIYRDTPRHEIHDINVSTCLRGDFADAYLTGDQSKVLPTDTQKQTAYSYAKEKGLISIETYGLELARHFVDDIEPVSGARIEIEEYAWERAIVDGSEHDYTWIRKGQEVRTASITISDTGTADAGTWVIGGLKDLVILKSTGSEFSGFLEDPYTILEPTDDRVMATTLVAQWRFVTTDVDWESVYVGIKAQIVKQFAQVHSLALQQTLFHIGKAILEEFPIIAEVRLSAPNKHHFEYALGLFGVENDNEVFHAADRPYGLIQAAVSRSDAPDAGPSWTPYSGWLS
>NZ_CP046099.1|WP_113683105.1|724344_725715_-|8-oxoguanine-deaminase
MTDPALGTTLVVANAHVVTMDSELSEHPDGYVVISGNKIVDVGAGKAPVYPNAHVIDGNGCLITPGLVNTHHHLYQWITRGLAADSTLFEWLTTLYPVWAGIDADAVHVAATGGLTWLAKTGCTTTTDHHYVVPRDAGDVFEAEITAAAQVGLRFHPCRGSMDLGQSSGGLPPDHVVEKLDDILTGTQSVIDRWHDPNAGSMLQIAVAPCSPFSVTESLLRESATLARENGVRMHTHLAETLDEESFCRELFGCTPVEYMERVGWVGPDVWYAHAVHLDDAGIETMARTGTAAAHCPTSNARLGAGIARAADLVKGGVTVGLGVDGAASNEACSLIEESRHALLFARAKGGPQTMTVRKALELGTIGGARVLGREGEIGSIEVGKLADLAVWKLDTVAHAGITDPVAALVLGSTPPLKLLLVNGQIVVADGRVTTVDEDVVASDVARAHRDLLGKA
>NZ_CP046099.1|WP_060938629.1|723527_724337_-|FAD-binding-molybdopterin-dehydrogenase
MDLHSVDEVLVPRTRSELPCASPGIGFIGGGTWLYSEPQPHLTTLVDLAGFDWKAVVVGDLGLEIAATCTIEELCRAGLPTSWSAAALFQHCADALLASWKVLRYATVGGNIALSFPAGAMTTLCTALDAELTIWRPDGTEYSVPVVDFVIDDSRNVLGPGEIIRSIRIPVHALTARTAMRKLAQTSLGRSAVAVAGRCGADGFTLAITAATRRPYALKFDELPDAAALADALHSRIPEDAYFTDVHGTAPWRKAMTDLLAEEIRGELE
>NZ_CP046099.1|WP_113683019.1|720819_723531_-|molybdopterin-dependent-oxidoreductase
MKYSVDGVPRDDQPRPGQCLRTFLREHGANSVKKGCDAGDCGACSVLVDGHPTHSCIFPAHRLGGRDVVTAAGLGTPEKLHPIQQAFVDAGGFQCGFCTAGMVVTASALSVEQKSDLACSMKGNLCRCTGYRSIRDALAGTSNTETAKTGGAQGRSIAAPASARIVTGTEQYTMDFSPGEKPIGLLHVAVLGSPHAHAHITRIDTAAAEAAPGVAAVLTFQDSPDVLFSTARHEDRNDDPDDTRVFDRTVRFRGQRVAAVIAETPTQAERALSLIEVDYEVLDAVFEPDLARSPGAPLLHGDKDESSRIAEVPRNVVAALHDGVGDLDRALADATAVVEGTWKTARVQHVALETHGAVGWLDEDGRLVIRSSTQVPFLVRDELAHIFDLDRSRIRVFAKRVGGGFGGKQELLTEDLVALAVLRTGRPVAYEFSRSDQFTIAPSRHPMRVSVRAGADADGTLTALAIDVLSDAGAYGNHSIGVMFHGCAESMAVYRAATKRVDAEAVYTNNVPSGAFRGYGLGQIIFAVEAAMDQLADRLGMDPFEFRRRNVVVPGDDFVDWHVEDGDLEFGSYGLDQCIDLVDSALSSGRGEAAPAGSRWQIGRGMAIAMIATIPPRGHFSDTTVALEADGRYVVNIGTAEFGNGTTTIHQQIAATELRTTVDRITIVQSDTDAGGYDTGAFGSTGTVVAGKALLIACERLRERILTRAVRLSGRGAQIDDLSPDGVETSHGCLDFATLLEGGPLAADGRHDGTPRSVSFNVHGFRVAVDTDTGRVKILQSVQAADAGTVMNPAQLRGQVEGGVGQALGAALSEEIVIEEGRVINPQLRNYHVPQIGDLPITEVLFADTYDKLGPFGAKSMSEAPFNPVAPALANAIANACGVRMYSTPMTPDRVWSELQARA
>NZ_CP046099.1|WP_113683014.1|731601_733002_-|condensation-protein
MEFTELADYAIPAGALVEWLPCATGPWVPDPRPVSYIHEAHLNRSAAGAGDKSWLGTAFEISGPLDVDAFRVALGRWIDRHEVLRSHTVLEPSSGEITRHTVPIGGIDIGVVSHGYDASSQDNFDHLHRLFDDYASPHSWPSYVFATLTPRGGDGPFTVFFAADHSIIDGFSIVLVAHEIAALYREASTGSAANLFPVGSYVDFGAVEREQMADMEAEKAAVEIWRKALGTDGLPQFPLPIGERGTDSQNGLSTWLLDAEQSKAFSSTCAAAGVGYFAGLLGGLAAVGREVAGSDQFEVVTPVHTRSAQEWAGALGWFVGLCPVEFAVGSDCSFVDLATRAAESIASVKPAAAVPFDRIGEHLETPIRPRFVVSYMDVRFVPEAAQWPEWNARALRSKAYTHDVYIWINRTPQGLNLAVRYPGNETANAAVHAYVATLRRTVEEIVAEPDTGTSGSYSSVVFETVS
>NZ_CP046099.1|WP_019747745.1|733008_733425_-|SufE-family-protein
MSTLPSALAEIVDDFAAVGASDKLTLLLEFSRELPPLPAELEQSAMEPVPECQSPLFLSVDDSDRDNVRLYFSAPPEAPTTRGFASILAQGLDGHSADEILGVPDDFYSALGLAEAVSPLRLRGMSAMLARIKRHLRG
>NZ_CP046099.1|WP_019747746.1|733421_734327_-|sulfurtransferase
MPVAPDPSTAFAEFAHPDRLVSTEWLSANLGTPGLKVVESDEDVLLYDVGHIPGAVKIDWHLDLNDPVTRDYIDGAKFAELMNRKGISRDDTVVIYGDKSNWWAAYALWVFTLFGHEDVRLLDGGRDAWIAENRDTAFDVPDITSTDYPVVKRNDAPIRAFKDDVLAHLGDGPLIDVRSPQEYTGERTHMPDYPEEGALRGGHIPSALSIPWAKAAAPDSRFRTRTELGEIYGGLSADDNIVAYCRIGERSSHTWFVLTHLLGYPNVRNYDGSWTEWGNAVRVPIVQGEEPGAVPSSVSAS
>NZ_CP046099.1|WP_060938607.1|734445_735909_-|condensation-protein
MHVTSIDRYGLEPGIVTEWSLQPADGAVTESEVPPSYNQHFHLETARTHGMGRSVWMAAAFDLPGELNRPALDLALRLFISRHDTLHTGFEVGEFTTTRMGLDPDGTHIETSEPVKFDSTEVLRAHLKKRFTTVCDPLTFPAYTFATVEREEHYTVLSAFDHTLVDGYSLVIALGELRQIYEGLIAIPELTDHEAVDAVMSRLGDPGSFVRYCELEADALLPVDNDPRIREWARFYEICGGTSPSFPLDLGVEAGKPAPQGADVRVLLDEELTATFDEICLSAGGSVFTGILTAMGLSVHSFTGQATLPLQFPLHIRKDPRWADAIGWLTTSAPITVQITPDADFGASLAHTHASFRVALTLEGVTMAQVRDALGDKIRRTRTDVFMVSYIDYRKLPGTDDHDLLNAHHISNVTVADDAQFWISRTNRGLSLRSRFPDTDTANETMVNFLTDLDRILREVCARGVTPIGSVTEQLRDSSVGAGTPRI
>NZ_CP046099.1|WP_113683013.1|735908_737402_-|acyltransferase
MDLNLITHWHPLPGRVIEWGVTHASAQRAAEAEIDRELPPTTMQDRHLRRARVTAEKGDPQSPWIGIAFDFAGTLDRDAMTRALQRYVRRHDTLHSWFSFDEATTDAADTAFEVRRHVVPVESIELEYRVGDDVSESEAIRALVATKFATETSALQWPAFVFGAVEHHHADLEADPSFTLFHAVDHAHSDMNSMVLMYAELRQLYAAEMTGSHPELGPAGSYAQFGRVERERTTELTMQSPEVHQWLGYLMRSGGSFPGFPLPLGAEDAPKPAIGSRFDLADDNECERFGAVCKANGANFIGGIFTALAIAEFELAGRDKYIALSPVSTRTEADSFAQGWYINLIPVGIDVDDKRRFTELAKLGQQGYHDGKALLDVSVQQVIDLVLSSLAESDSAPGGLSKTLTPPPIVSYIDGRRMPDPYSYAETKATGIVGGKETQIASMWINRMHTGTWIAVSHPDTPIAHESATRFAEHVSKIIKTVAAQGDYSFSAPEGAS
>NZ_CP046099.1|WP_113683012.1|737552_739250_+|MFS-transporter
MLPDPLGDAVGADHKGGRRAGSLTPWLGLATSLAAAFMQLLDATIVNVALPSIAVDLQAGVSAQLLMVSVYILAFACSLITAARLGDLFGRRVVFLTALFVFVAASLLCGLAQSATMLIVFRGLQGLAAGSMSAQTFAIISGLFPKARHPRVFGIYGATIGLATVSGPLIGGLLIEWNLFDWGWRLIFLVNIPIGIAALILGYFHLVDARAEHVRSLDLIGAALSSLALFLLILPLAEGRPRGWPTGLVVMLAMSVPVALAFVLYESRLAKRGGDPVLRLELFRDRAFAIGAVLAFVFFGTLTSLIFTISLTLQFGFGFSALRAGVMTLPWAVGMGVAAVLSSAVYRMLGNRVLILGMVVFAGSLIALSVILEHEGTDPRWLALAGPLLLGGAGLGLFVAPLQTAILATVEPAHAGSVSGLLPTVQQVGSSIGLALIGVVFFSLVAGQAPQAVQGERPEYVANLEAAGVNPGLVDIAEKAFVDCATSQLASGSPMEVAPECRREGTAGAGGQSVQVAVDAAYASTRAAAGEAFLEAQRRVLAIIAAIALGIGLASTALPRVNSPV
>NZ_CP046099.1|WP_113683011.1|739312_740617_+|HNH-endonuclease
MSVLLSDVVSGSAVGLRGRLWRLTAAELRAAAVSASAEILRLEAVRVAVVDELSLRPDDQVIASRGVGSWLAANTMLQIRDGKKIAALGAALRPFPAVAARFDVGDCSFEHAVLIVAFCESPPKGMPEEALPRCIDLLLAAASGVEATTTKVRNVIATLERVFESDEIPPAEDVDRNELRIASTLNGRVVVRGDFDAITGEMLLSALSNLTMPTPAPDGTPDARSAAKRTADGFTELIRRYLDCAKTGTDGGQRPHVNVHINARDLAEHRDCAAAPSPDGGGVAVSDLDVGHMPWLGPLSVSQTRLLGCDCFLSTVLLDDHGAPLDAKPGKRLVSAEQRVALIARDKGCAFPGCTCVPAWTDAHHIRHWANGGPTVMSNLVLLCRSHHRLMHRKSRFVGKWEIRIGVDNKPWFIPPPSIDPRQHPRPANTTFKT
>NZ_CP046099.1|WP_007731146.1|740741_741383_-|septum-formation-inhibitor-Maf
MTQLVLASASPARLAVLRAAGVSPLVRVSGVDEDKIADNLGPDAAPEKVVTVLAEAKAAEIVPGLAADNLTDVVVVGCDSMLLIDGQLQGKPGSVDIARKRWAAMAGRSATLLTGHCVLRVADGRIVRMASDHSATVVHFAQPSTEDLEAYLATGEPLQVAGAFTLDSLGGWFVERIEGDPSSVIGIGLPLVRTLLERVGVSVSDLWRTQSIF
>NZ_CP046099.1|WP_019747751.1|741398_741740_-|acyl-CoA-carboxylase-subunit-epsilon
MTATTEDILSEDVALAETAPTNGAVVEGSATDASLTELTETSTSDASVIKIVKGSPTDVEIAALVSVLAAAAGSGQAPESNVPAETWGDPTQFHRTRAPFSPYAYLNPAIRRS
>NZ_CP046099.1|WP_003940853.1|741736_743377_-|acyl-CoA-carboxylase-subunit-beta
MTTVQEPNAPEAAAAPDIHTTAGKLADLRNRQAQAQAPSGEAAIDKVHAKGKLTARERITALLDEGSFVELDALARHRSVNFGLADNRPVGDGVVTGYGTIDGRDVCVFSQDATVFGGSLGEIYGEKIVKVMDLAIRTGRPLVGINEGAGARIQEGVVSLGLYGEIFHRNVQASGVIPQISLIMGPAAGGHVYSPALTDFVVMVDETSQMFVTGPDVIKTVTGEDVTMEDLGGARTHMVKSGVAHYVASGEQDALDYVKDLLSYLPSNNQAAAPRGEITDPIVGSIEDSLTAEDIELDTLIPDSANQPYDMHEVIRRILDDDEFLEVQAERAMNIIVGFGRVDGRSVGIVANQPTQFAGCLDIDASEKAARFVRTCDAFNVPIITLVDVPGFLPGTEQEYNGIIRRGAKLLYAYGEATVGKITVITRKAYGGAYDVMGSKHMGADVNLAWPTAQIAVMGASGAVGFVYRKQLLEAAKNGEDVDALRLKLQNEYEDTLVNPYVAAERGYVDAVIPPSHTRGQIVSALRLLERKAVSLPPKKHGNIPL

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Crispr_ID: NZ_CP046099_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046099_2

4919584-4919700

Orphan

Consensus_repeat	Method
GAAGCTGAACGGGTTGTCGACGAGGGCGTTGGTGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046099_2

>merge|NZ_CP046099|2|4919584-4919700|CRISPRCasFinder
GAAGCTGAACGGGTTGTCGACGAGGGCGTTGGTGCCCACACCCTGCAGAGCGTGTGCGGACGTCGCCTCGGCAACCGGCTCGAAGGTGAACGGGTTGTCGACGAGGGCGTTGGTGCC

>NZ_CP046099|2|2|4919584-4919700|CRISPRCasFinder
GAAGCTGAACGGGTTGTCGACGAGGGCGTTGGTGCC	CACACCCTGCAGAGCGTGTGCGGACGTCGCCTCGGCAACCGGCTC
GAAGGTGAACGGGTTGTCGACGAGGGCGTTGGTGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046099.1\|WP_021332670.1\|4909366_4910569_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP046099.1\|WP_113683412.1\|4910608_4911730_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223650
NZ_CP046099.1\|WP_020968054.1\|4922263_4923058_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
NZ_CP046099.1\|WP_113683419.1\|4924039_4924726_+\|SagB/ThcOx-family-dehydrogenase	unknown	unknown	gnl\|CDD\|188352
NZ_CP046099.1\|WP_113683413.1\|4913025_4913652_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP046099.1\|WP_113683417.1\|4918667_4919480_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274832
NZ_CP046099.1\|WP_029254151.1\|4927188_4928436_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046099.1\|WP_113683414.1\|4913703_4914675_+\|sugar-nucleotide-binding-protein	unknown	unknown	gnl\|CDD\|224662
NZ_CP046099.1\|WP_051119058.1\|4925473_4927120_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340879
NZ_CP046099.1\|WP_020968047.1\|4911726_4912467_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP046099.1\|WP_020968055.1\|4923054_4924035_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238568
NZ_CP046099.1\|WP_031330989.1\|4919855_4921115_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP046099.1\|WP_070384763.1\|4925017_4925470_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046099.1\|WP_019746321.1\|4928454_4929042_+\|DinB-family-protein	unknown	unknown	gnl\|CDD\|368218
NZ_CP046099.1\|WP_020968057.1\|4924727_4925021_-\|SHOCT-domain-containing-protein	unknown	unknown	gnl\|CDD\|378276
NZ_CP046099.1\|WP_003943598.1\|4912578_4913019_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|379177
NZ_CP046099.1\|WP_113683418.1\|4921199_4922267_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NZ_CP046099.1\|WP_113683415.1\|4914621_4915914_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274674
NZ_CP046099.1\|WP_070796733.1\|4917243_4918671_-\|CocE/NonD-family-hydrolase	unknown	unknown	gnl\|CDD\|225487
NZ_CP046099.1\|WP_113683416.1\|4915910_4917251_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274674

Protein	Function_ID	Function_description	E-value
NZ_CP046099.1\|WP_021332670.1\|4909366_4910569_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.74542e-52
NZ_CP046099.1\|WP_113683412.1\|4910608_4911730_+\|ABC-transporter-permease	gnl\|CDD\|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	7.1943e-11
NZ_CP046099.1\|WP_020968054.1\|4922263_4923058_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	9.29486e-103
NZ_CP046099.1\|WP_113683419.1\|4924039_4924726_+\|SagB/ThcOx-family-dehydrogenase	gnl\|CDD\|188352	TIGR03605, antibiot_sagB, SagB-type dehydrogenase domain. SagB of Sterptococcus pyogenes participates in the maturation of streptolysin S from a ribosomally produced precursor polypeptide. Chemically similar systems operate on highly diverse sets of bacteriocin precursors in numerous other bacteria. This model describes a domain within SgaB and homologous regions from other proteins, many of which appear to be involved in biosynthesis of secondary metabolites. While some substrates may be intermediates in non-ribosomal peptide syntheses, others are involved in heterocycle-containing bacteriocin biosynthesis, and can be found near SgaC-like (see TIGR03603, cyclodehydratase) and SgaD-like (see TIGR03604, "docking") proteins. Members of this domain family are heterogeneous in length, as many have a partial second copy of the domain represented here. The incomplete second domain scores below the cutoffs to this model in most cases.	5.9122e-26
NZ_CP046099.1\|WP_113683413.1\|4913025_4913652_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.51533e-09
NZ_CP046099.1\|WP_113683417.1\|4918667_4919480_-\|hypothetical-protein	gnl\|CDD\|274832	TIGR03882, hypothetical_protein, bacteriocin biosynthesis cyclodehydratase domain. This model describes a ThiF-like domain of a fusion protein found in clusters associated with the production of TOMMs (thiazole/oxazole-modified microcins), small bacteriocins with characteristic heterocycle modifications. This domain is presumed to act as a cyclodehydratase, as do members of the SagC family modeled by TIGR03603.	0.000218451
NZ_CP046099.1\|WP_113683414.1\|4913703_4914675_+\|sugar-nucleotide-binding-protein	gnl\|CDD\|224662	COG1748, LYS9, Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism].	2.28452e-11
NZ_CP046099.1\|WP_051119058.1\|4925473_4927120_-\|MFS-transporter	gnl\|CDD\|340879	cd17321, MFS_MMR_MDR_like, Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.21074e-22
NZ_CP046099.1\|WP_020968047.1\|4911726_4912467_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	8.44651e-80
NZ_CP046099.1\|WP_020968055.1\|4923054_4924035_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238568	cd01148, TroA_a, Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains.	1.12288e-45
NZ_CP046099.1\|WP_031330989.1\|4919855_4921115_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.79878e-54
NZ_CP046099.1\|WP_019746321.1\|4928454_4929042_+\|DinB-family-protein	gnl\|CDD\|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	9.98775e-42
NZ_CP046099.1\|WP_020968057.1\|4924727_4925021_-\|SHOCT-domain-containing-protein	gnl\|CDD\|378276	pfam09851, SHOCT, Short C-terminal domain.	2.29799e-06
NZ_CP046099.1\|WP_003943598.1\|4912578_4913019_+\|PAS-domain-S-box-protein	gnl\|CDD\|379177	pfam13426, PAS_9, PAS domain.	3.26675e-11
NZ_CP046099.1\|WP_113683418.1\|4921199_4922267_+\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	5.70038e-91
NZ_CP046099.1\|WP_113683415.1\|4914621_4915914_-\|hypothetical-protein	gnl\|CDD\|274674	TIGR03604, hypothetical_protein, thiazole/oxazole-forming peptide maturase, SagD family component. Members of this protein family include enzymes related to SagD, previously referred to as a scaffold or docking protein involved in the biosynthesis of streptolysin S in Streptococcus pyogenes from the protoxin polypeptide (product of the sagA gene). Newer evidence describes an enzymatic activity, an ATP-dependent cyclodehydration reaction, previously ascribed to the SagC component. This protein family serves as a marker for widely distributed prokaryotic systems for making a general class of heterocycle-containing bacteriocins.	2.79853e-69
NZ_CP046099.1\|WP_070796733.1\|4917243_4918671_-\|CocE/NonD-family-hydrolase	gnl\|CDD\|225487	COG2936, COG2936, Predicted acyl esterases [General function prediction only].	1.80028e-33
NZ_CP046099.1\|WP_113683416.1\|4915910_4917251_-\|hypothetical-protein	gnl\|CDD\|274674	TIGR03604, hypothetical_protein, thiazole/oxazole-forming peptide maturase, SagD family component. Members of this protein family include enzymes related to SagD, previously referred to as a scaffold or docking protein involved in the biosynthesis of streptolysin S in Streptococcus pyogenes from the protoxin polypeptide (product of the sagA gene). Newer evidence describes an enzymatic activity, an ATP-dependent cyclodehydration reaction, previously ascribed to the SagC component. This protein family serves as a marker for widely distributed prokaryotic systems for making a general class of heterocycle-containing bacteriocins.	7.62106e-71

>NZ_CP046099.1|WP_113683417.1|4918667_4919480_-|hypothetical-protein
MYALADGHQLYPTPDGTWHYLTPDENAVTIGAPAEDLAKLDNFLRRSGSVLGPGAIEIADALASRGVLAVPGQVPEIPGPQRVLMDGVGPVADACIALLSKALPDLDVVSTTAPIEDDVASSDLVLSVADAPPHDAWSELDTWCRHSRTPWQRVHAELGEICIGPFFDGIDSASYRDVCGRRLAASRVPDHLLALWNHLADSERRPLGLSPTTAAMVSALACSDVVASSYGAPQSHLHHQIRMNPRTLMMTRHPVLPLPGGVLEPSPTLR
>NZ_CP046099.1|WP_070796733.1|4917243_4918671_-|CocE/NonD-family-hydrolase
MISLGVKIPAADGSSLATDVLLPDSSPRGLIVIRTPYGRGWHLAEGLEWRSRGIAFICQDVRGRHDSTGSWEPYVHEREDAAALAEWLQDQPWTPECVIASGASYAAGTAWAFTAETNGADRAFRARGVVSKVPTIGSDRVKRDPSGILLLAEHLAWWGEHGDSSSSREGFIPALMRSDSSLLEHLPVQSMIEDVGLTSDSPGWLTPIRRAREREDFGGDDLVSADELSELDVAGLHIGGWDDAMIRETLRHFASVWRGPQSLIVGPWAHDLRPGRVGETSFGRLQVEWMESIFSARPVTINRVFDRGAGEWSTEPYVTGANRIRLEPDPRTAPFNFTHHADEGRNDCVVWTFDMEVECVLSGMPSVELTVHSPQGEADWIAELSVVDPTRVTRSIARGAGVSLCSGTLTIDLDPVLHTVRAGDVLTLRIAGSDFPRLARNLGDGDRYRGTRSTALHQSFSGSLTLPILGGTAGG
>NZ_CP046099.1|WP_113683416.1|4915910_4917251_-|hypothetical-protein
MDDLLVDARSGVLTSLEPHIRSDMPTGWVGWAARVADTRNFGGSGSLFRADPYGFGASIRDDAAARGAATGEAVERYCGNVVPEDLIRSSASALELAGSRVVDPAKFALYSEDQYRLPGFPFVPFTSALEIRWALGHTMDEKVPTYVPAALTYLGYYTGTRRGEPPIASLQYAGIAAGRSRAEAEMSALLELLERDATALWWCGDRSQPAIELADWERLPVHRQLGDLESDTRSVRVLLLPSPFGIPVAAVWIRDDRRGLVALGTACRPTVEAAVSKALVEAYAVLAITIDLADPDGPTWRSVADGTLPAHLYKPFRADRRYRDEFDAQWKDVVDLPTVAQLYLDPVMAGAAEEHLFDYTETRSVSEIPDEDPVNLASLVALLTSRGYQPISVDLTTRDISIAGLHVVRVLSPGLYNNAPAAFPLLGGSRLTSASTTHLHLPVPLA
>NZ_CP046099.1|WP_113683415.1|4914621_4915914_-|hypothetical-protein
MRSLLVDRRTGIIRELVDAVVPQHFPPEFKLIHSYASDSARFSPWSSDSAGAGYCFDLGDRARPTAAAIGEAVERYCGNIVAKPIVRGSADALIGASIDLSQLARFDAAQYARPQFPFVEPTDDLELDWTRGVDLITGSDIWVPAELVWGSYPHFVARTGPAISPVAQAGLAAGPTTEFAIRNALREIVERDAMTLSWTGRRGVRIVTGIPEVLRRLGNHGSLSTRWLSFDSDFGIPVLGALVHDRLTGYSTMGTACHEEAQTAAFKSLGEALQLQLLSADYDNPESGIGRAAASPTSPLAPWRADRSYAGAYRSDFADVMDYGCHLQLHLDPEIQARFESELAGAVVGEVDLDSLTSPIDTESALTGSGFRPAWVDLTTADVLRAGLHVVRAVVPGCLTNAAAGLPFLGSPRLVDSLAGHPIRTIPLPH
>NZ_CP046099.1|WP_113683414.1|4913703_4914675_+|sugar-nucleotide-binding-protein
MTKVLVLGGYGAVGIPLMKQLAKVPEISAYSAGRDRARADVVVDLKEPGAYSAAVRDFDVVVNASGFEDVRLAEEAVRGGAAFVDITATSSYCEELEAVDGPVLMGVGLAPGLTSVLAAEAHRLGDGPVDIVIGLGGGELHGPAATAWTYGMLGTRFPDPDGRSIRNYAGMKTFRMPADATGYRTGPAVRADFSDQHALTRDLGVPVRTYLRLDTSTATLGLAAMTWAPALQKVVPKKLWGSDRWVAMARTDTVPALWVSGRSQSAATATIAARAVQVIRDRAISKPTWFHAVETAESLQLAVPELSVRQWDGANWMSGKTVD
>NZ_CP046099.1|WP_113683413.1|4913025_4913652_-|TetR/AcrR-family-transcriptional-regulator
MTEVLREDTSARRKIIEAAREVFVDPGYAAATIKQLAAAAGVSVQSVYFVFGNKPSVLSALLDVAVAGDEEKTATLDRPWVAAALGAPHPLGQLRIQVHHGRLILERTADILLALRAAASADEDAARLWQINRTQRRTVQEHLMVGIVEKAPTVDLETAVNVALTLLSPETYTDLVVGAGWTGQKYEEWVVNTLAATLGLDRTVKYRK
>NZ_CP046099.1|WP_003943598.1|4912578_4913019_+|PAS-domain-S-box-protein
MERRRNVAQPPQSPIADLEQMPALILLDRLPVPVMAVHRDGSIVFANPSFADMLGYPKKAVSALRLQDILYDKDADDVSAEQAHRELSSEPGSVKEFVHSDSTLVRATVSQSLLRRDDDTITLAVLHDLTERLWNNPRHIDDKPTK
>NZ_CP046099.1|WP_020968047.1|4911726_4912467_+|ABC-transporter-ATP-binding-protein
MTMTTGTTVLDIQNVDLTFPDGQSRVTALDDVSLRLHRGEIAAITGPSGSGKSSLLAVASTLIRPDSGHVYLRTPEGSTDIAALSRRAASELRRSSIGIVFQQSNLVSSLTALEQLEVMAHLGQSVFTSRTRRKAVKSKAMDLLDAVGLADQSGKRPSQLSGGQRQRVNLARALMNDPQLLVVDEPTSALDQERGAAVMDLIIGVVREHEAATLLVTHDRSHLSRMDTVYRVVDGSLAEDQEALAA
>NZ_CP046099.1|WP_113683412.1|4910608_4911730_+|ABC-transporter-permease
MSIRGAMEKVCIRESVEASTGKEFTVFVAMRDLRAARGRFALISVVVLLVALLVSFLSGLTAGLRHQNVSAIEAMNADTVVFADTGAGASFDESALTQDQVNAWAGAAKDVDPIGIGRGKAGLADGNQKSVALFGADGGFGDVTPSASGTVVLSEGAARDLGAGAGDQVSVGTQQFTVSDVRGDDWYSHSPVVWMTLGNWQAANPRGGVATVLAVTGASDASATDKSAATTSTTVSGSLDAIGSYKSENGSLTLMTLMLFAISALVIGAFFTVWTIQRTPDIATLKALGATTGSLVRDALGQALIVLIAGVTVGIGLTAVAGSLIGDAMPFVLDASTTVVPAVALIGLGLLGAAFALRFLSTTDPLTAVGSAR
>NZ_CP046099.1|WP_021332670.1|4909366_4910569_-|sensor-histidine-kinase
MDEPGPNLAKLGEMHRSPLTPVFAGLQLGLHVLVMALAGVVFLRALIDESDLTATIIALAVIFVAVYLFGVAKRLRGNAARWWLAVLTLVWIATMAVSADAAYLAFGLFFLYLHILRRPWSLLAVTAATAVAVIGTGLHRGWTVAGAVGPIIGAAVAVAIGLGYQALYREAAERGRLIDELMNTREELASTSRDAGKFAERERLAAEIHDTVAQGLSSIQMLLHAAERADPESPAIRQISLARETAADSLAETRQLIAELTPAALDGQSLADALRRICERASSPELEARSVVEGEAIRLPMPLEATLVRIAQGAVSNVLRHADATRMAVTLTYSDNTVSLDVVDNGRGFDVEVLERGPAESFGLNAIRRRVELQGGTFSIESEPGHTAVAVTFPLDVGEQ
>NZ_CP046099.1|WP_031330989.1|4919855_4921115_+|MFS-transporter
MSETSTTGSAEAQPHVFRDRSFRFFFTARTIAVAGAAVTGVAMPILVFDISRSPFLTSLAAAGTVLPYLVFGLFAGAVADRVNRRTVILCAQAVAALALASIPAAQALGVLTAWHAVGVSMCIGTCFVWFDAAAFGALPALVGRQRIPAANSALWTSSTLVDVAFPAIAGVLVASIGPAYALGADALAYVLAGLAMASIGASFSSTPAAPKKSEPGIARDIREGLSFLWQSPLLRALTGVGFVNSLTQGAVTALLVVYATERLGISTSSPMIGAVWTAVSVGGVVGAVLLPRLPAQWPVGAITVGALTIAPVVLFVVATTSNTAAAITALTVYSGCATVTILNGIGARQRLTPDRLQGRVNTTARMVAWGGSPVGALIAGAIAGRWDIGTAYLVACSFALVGALFAWVSALRTDPCPHR
>NZ_CP046099.1|WP_113683418.1|4921199_4922267_+|iron-ABC-transporter-permease
MTLTSEAVPDAPSRAHPVGDRGYVPFLLATAVVLATASTVAVWSGAASLSFADVFAVLYAHVGGPPVDPLLDRIVWGLRVPRILIAALAGAGLSLAGAVLQALVRNPIADPYILGVGSGASFGAVLIMTTGIGTGLSIGVPVAAFLGAMVSLIAVLVLGRREGMLVPLRMVLAGVAIGYLLSAATSFVQLRADPSQLSGVLFWLLGSVSGAGWSDLGVPAAVITVCAAVLLTQSRQLNALAMGDESAQSVGVDVRRTRLLLLVIASLLTAVVVSVAGGIGFVGLLVPHAVRLLVGSDHRKLLPATALVGATFLVIVDLAARMLDAPNELPLGIITAGLGAPFFLWLLRRDGGAQS
>NZ_CP046099.1|WP_020968054.1|4922263_4923058_+|ABC-transporter-ATP-binding-protein
MRLSASGIHVVRGGRLVVSGVDLEAPEGSVVGLVGPNGSGKSSLLRALYRSMKPRSGIVKVDEVNVWDDLSPRSAARIIGVVGQEHSSDFSFSVREVVATGRTPHHSAFSRLGEIDRDIVSAALARTGMHGFGSRLFAELSGGEKQRVMLARAIAQQPSVLVLDEPTNHLDIRAQLELMELVAELGTTTIVAIHELALAAAYCDYVCLLSGGVVVATGPTAEVLTEDLLSEVFGVQVHLGTHPLTGRPLLSFAPPLLHTKEAVS
>NZ_CP046099.1|WP_020968055.1|4923054_4924035_+|ABC-transporter-substrate-binding-protein
MKSSIRTAALLCSAVTATAVLTACGNSTADSAASSSEKISVTNCDREVTLPKTAERIVSLYPSMTELLIQLGAADRIVGQSNTDLSPPSPELADQFAAVPVLSTGVPAKEALLDARPDLIVSDGEYWFDGDRLQSMDELRDLGIPIFVNSGYCHKAVTEGRIDDVWSDIDGLGALTGTSDEAATLLADGKKSLAATEASVAGKEPVATVMVQVSEGQSYALARGLYSSVLEAAGGKNLYESDLPDGKYFGQVATESILAKSPQAILVVYSTESARESTLEAARTAFAGTPAATSNAIFAVPEAWFAGELVSIDGAAEVSRLLHPGS
>NZ_CP046099.1|WP_113683419.1|4924039_4924726_+|SagB/ThcOx-family-dehydrogenase
MTALERVEAVVSLHAALDRTVAPSELPFDEGALPPVTSEFVELPAPTPLPAQDFPDILQARRSHFNPAQDALGIDELSNVLHHSLVSSPTAGGMRELTLSFVVSHPGPSLGAGVYRYIQEGRAEAVRPGDVQGNLRASLLQPEFVDVFPVLLFVVADVEAPLEKYAMRHYRTMHVDAGVLVQNLYLVTEAMGLVGCAIAGFTDARVASLLNLATTQLPVMAFALGRPS
>NZ_CP046099.1|WP_020968057.1|4924727_4925021_-|SHOCT-domain-containing-protein
MSFLRRAGRVAVASSIHGNVQRRQRTRWAAEDQARAAQVQPVPPIPDLPPLPPQAPPAESEMSMDAKLEQLTKLGELKNAGVLTEAEFETQKARILA
>NZ_CP046099.1|WP_070384763.1|4925017_4925470_-|hypothetical-protein
MSNQDQFGPIEYVAVEFPSGAPTSAGFEQLLTLVDSGVIRILDLEFVTKAADGSVSVVPASTFELADFDLAQFDGAASGLLDAGDIAAVGEELAAGSVAAVLVYEELAILPVIEAWTRSGAKVVTEGHLSVDELAAALDNTAPDTTEKDA
>NZ_CP046099.1|WP_051119058.1|4925473_4927120_-|MFS-transporter
MSVKPGAADTSAAVTTASWLPLIVVVLTQIQASFAVNALTVSMAGITTDLDTPATSVGTAITAGTFAMAAFILLGAKIGARYGTRLVFQIAVAIHGLAMAAVALSQSPAMLFVAQAASGAVIALIAPALTVFIATNFNGDQQAKAIGYLAAAIPAAGVLALLIAGSFATTIGWRYSFALVVALAVVNLVLSFRVKPVPPQKDITIDWAGAALAAVAVILLSFGFSGLNSWGVILATDAAPFSVIGVSPAAILIVLGTICAQGFFQWTRSRKAQNKPQLFNLDVLKTGAERATTICMATMMFVGTAANFLIPLYMQIIQGRSSLQTSFSIIPYTLSIFIASTVVARLYKTYSPRLIARAGFVVVAAGLILLAFTIRGDWHQIFVVIGLITLGLGQGAIVALVFNTLLTAAPKELAGDVGAWRGLVHNMSGSVGIAVASVFAVGILGTLVSSQLIDNPTIPASLKVESGINLDQVNFVPNDQLVVTLENTSATQAQIDEAIRINTEARLRALRTSLLVLAGLSLLAIIPAGRMPNEVPALDEPQPTKGKK
>NZ_CP046099.1|WP_029254151.1|4927188_4928436_-|hypothetical-protein
MEQTLTAVEDLTEVASRAVAAERDARSVRWHNPAAVRKAAASVRDSLDDERSALSRPSYSGLSPSPHMARQLELITTLQPPLPADAGISTAAQAEADAVAAVTTARIALRAAHLAVLEARVAALDAGDTDTVAAAIRGYVPLNSGNPVVRHVQDLGSRIREEARHVVSGKPRSIAFRLGLSLGVGLAYLAFIRLFQWDSKEDRLPYLALYALSGVVGSVVCTNALSFDAGRVRAALSGGTRLWHVLVAKNTMMLLLVGSAGFLLSAILAWRSGSSADLVKACGQVLTMILLWLGVANVMSVALPLRAEPMTARRHDGTWKQFLLSFVISYGVGLIVNLMLYWRVWAKTTLLERMGGPWIPVLLLLASAAATWLLLTVLAVLLAEQPRFRRALQREMVVYREETNHLQATIQHNSG
>NZ_CP046099.1|WP_019746321.1|4928454_4929042_+|DinB-family-protein
MTTNSEKEDLQRYLQAARDALVWKLDGLSEYDIRRPMTRTGTNLLGLVKHMIGVELGYFGPTFGRRVPDLPAWLRSEELNVDMWARADESSADIVETYRRTWAFADATIEQHDLDAPGFVKHWPEDRRDVTLHRILVHVVTEIHRHAGHADIVRELIDGAAGMKAGDNNLAPGDEAWWAEYNDRLETAAREAHHA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

908384 : 915963

Lactobacillus_phage(16.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_019747884.1\|908384_908951_+	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	7.3e-06	33.9
WP_113682982.1\|909023_909851_-	siderophore-interacting protein	NA	NA	NA	NA
WP_019747886.1\|910142_910373_+	glutaredoxin-like protein NrdH	V5UN81	Mycobacterium_phage	1.5e-21	64.0
WP_003944767.1\|910455_910935_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A217ER62	Bacillus_phage	4.5e-09	30.1
WP_085989958.1\|910916_913076_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	V9VI16	Lactococcus_phage	1.5e-205	51.0
WP_003944723.1\|913136_913349_-	hypothetical protein	NA	NA	NA	NA
WP_085989609.1\|913361_914186_-	SPFH domain-containing protein	NA	NA	NA	NA
WP_003944744.1\|914449_915415_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A0N7CCA3	Skermania_phage	7.7e-157	86.8
WP_029255089.1\|915489_915963_-	NUDIX domain-containing protein	D0R7J3	Paenibacillus_phage	1.1e-12	31.2

DBSCAN-SWA_2

2434818 : 2512471

Gordonia_phage(32.26%)

tRNA,capsid,integrase,portal,protease,head

attL 2444377:2444393|attR 2505311:2505327

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_024487630.1\|2434818_2437500_-\|tRNA	valine--tRNA ligase	A0A1V0SK04	Klosneuvirus	1.1e-144	39.4
WP_113683741.1\|2437672_2438374_+	hypothetical protein	NA	NA	NA	NA
WP_113683742.1\|2438446_2440483_-	S9 family peptidase	NA	NA	NA	NA
WP_003944518.1\|2440492_2441107_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_019749076.1\|2441186_2442194_-	iron-siderophore ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_113683743.1\|2442278_2444624_+	FdhF/YdeP family oxidoreductase	NA	NA	NA	NA
2444377:2444393	attL	NA	NA	NA	NA
WP_020908229.1\|2444625_2445495_+	formate dehydrogenase accessory sulfurtransferase FdhD	NA	NA	NA	NA
WP_113683744.1\|2445445_2447359_-	sugar phosphate isomerase/epimerase and 4-hydroxyphenylpyruvate domain-containing protein	NA	NA	NA	NA
WP_113683745.1\|2447355_2448234_-	shikimate dehydrogenase	NA	NA	NA	NA
WP_029255676.1\|2448233_2448683_-	type II 3-dehydroquinate dehydratase	NA	NA	NA	NA
WP_019749082.1\|2448810_2449485_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_113683762.1\|2449556_2451779_+	beta-glucosidase	NA	NA	NA	NA
WP_020970000.1\|2451982_2453320_+	MHS family MFS transporter	NA	NA	NA	NA
WP_003944582.1\|2453404_2454685_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	2.4e-142	60.2
WP_003944539.1\|2455054_2455717_-\|protease	ATP-dependent Clp protease proteolytic subunit	A0A248SJ97	Salicola_phage	3.8e-30	39.5
WP_007730960.1\|2455765_2456353_-\|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	1.2e-43	49.5
WP_113683746.1\|2456569_2458132_-	trigger factor	NA	NA	NA	NA
WP_113683763.1\|2458831_2459590_+	GA module-containing protein	NA	NA	NA	NA
WP_113683747.1\|2459586_2460384_-	Fpg/Nei family DNA glycosylase	A0A1V0CNR6	Kaumoebavirus	2.2e-08	25.5
WP_003944571.1\|2460399_2460873_-	ribose-5-phosphate isomerase	NA	NA	NA	NA
WP_021333424.1\|2460973_2461852_+	M48 family metallopeptidase	NA	NA	NA	NA
WP_003944541.1\|2461839_2462463_-	DSBA oxidoreductase	NA	NA	NA	NA
WP_020908238.1\|2462629_2463865_+	ferredoxin reductase	A0A2K5B2C5	Erysipelothrix_phage	1.9e-06	27.7
WP_113683748.1\|2463930_2466510_+	aminopeptidase N	A0A2K9L1R3	Tupanvirus	1.0e-46	33.7
WP_019749092.1\|2466581_2467061_-	DUF5130 domain-containing protein	NA	NA	NA	NA
WP_007730943.1\|2467047_2467311_-	hypothetical protein	NA	NA	NA	NA
WP_019749093.1\|2467485_2468031_-	HNH endonuclease	H6WG01	Cyanophage	1.4e-17	35.2
WP_003944464.1\|2468366_2468774_+	globin	NA	NA	NA	NA
WP_021344735.1\|2468778_2469213_-	DUF861 domain-containing protein	NA	NA	NA	NA
WP_020970005.1\|2469376_2470975_+	glycoside hydrolase family 13 protein	NA	NA	NA	NA
WP_019749097.1\|2471041_2471728_-	hypothetical protein	NA	NA	NA	NA
WP_042450296.1\|2471720_2472095_-	4-hydroxybenzoyl-CoA thioesterase	NA	NA	NA	NA
WP_113683749.1\|2472136_2476984_-	NAD-glutamate dehydrogenase	NA	NA	NA	NA
WP_019749099.1\|2477083_2477503_-	acyl-CoA thioesterase	NA	NA	NA	NA
WP_007730925.1\|2477507_2479187_-	energy-dependent translational throttle protein EttA	A0A1V0SKJ1	Klosneuvirus	4.2e-49	28.2
WP_154606669.1\|2479353_2480532_-	hydroxylase	NA	NA	NA	NA
WP_053061983.1\|2480627_2482445_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	7.7e-49	29.1
WP_020970009.1\|2482551_2483010_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_007733347.1\|2483014_2483428_-	single-stranded DNA-binding protein	A0A2D1GPQ1	Mycobacterium_phage	1.4e-14	37.3
WP_113684270.1\|2483609_2485745_-	bifunctional copper resistance protein CopD/cytochrome c oxidase assembly protein	NA	NA	NA	NA
WP_113684269.1\|2486022_2487285_-\|integrase	site-specific integrase	G9FH48	Rhodococcus_phage	4.5e-80	44.1
WP_113684268.1\|2487604_2487763_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_113684267.1\|2488179_2488374_+	hypothetical protein	NA	NA	NA	NA
WP_113684266.1\|2488430_2490152_+	AAA family ATPase	NA	NA	NA	NA
WP_113684265.1\|2490451_2491000_+	hypothetical protein	NA	NA	NA	NA
WP_154606670.1\|2491371_2491782_+	hypothetical protein	NA	NA	NA	NA
WP_113684263.1\|2492624_2493284_+	hypothetical protein	G3M5F8	Mycobacterium_phage	3.6e-33	42.9
WP_113684262.1\|2493565_2494333_+	hypothetical protein	A0A1D8EX78	Mycobacterium_phage	1.0e-26	46.4
WP_154606671.1\|2494563_2494884_+	hypothetical protein	A0A1B3AZ51	Gordonia_phage	3.7e-07	43.2
WP_113684260.1\|2494990_2496388_+	hypothetical protein	A0A142KC08	Gordonia_phage	3.4e-89	43.0
WP_113684259.1\|2496396_2496603_+	hypothetical protein	W0LPT9	Mycobacterium_phage	8.2e-08	50.0
WP_113684258.1\|2496613_2497885_+\|portal	phage portal protein	A0A142K7D9	Mycobacterium_phage	8.1e-146	58.9
WP_113684275.1\|2497887_2498562_+\|head,protease	HK97 family phage prohead protease	A0A097EYK1	Mycobacterium_phage	6.5e-54	53.4
WP_113684257.1\|2498584_2499889_+\|capsid	phage major capsid protein	A0A222ZEN6	Arthrobacter_phage	6.8e-132	60.9
WP_154606672.1\|2499953_2500109_+	hypothetical protein	NA	NA	NA	NA
WP_113684256.1\|2500111_2500615_+	hypothetical protein	A0A2H4P9V1	Gordonia_phage	1.6e-17	36.2
WP_113684255.1\|2500611_2500932_+	hypothetical protein	NA	NA	NA	NA
WP_113684254.1\|2500934_2501213_+	hypothetical protein	A0A142K9Z8	Gordonia_phage	1.1e-07	41.3
WP_113684253.1\|2501209_2501623_+	hypothetical protein	NA	NA	NA	NA
WP_113684252.1\|2501666_2502482_+	hypothetical protein	A0A160DDD4	Gordonia_phage	8.0e-14	45.4
WP_113684251.1\|2502631_2502865_-	hypothetical protein	NA	NA	NA	NA
WP_113684250.1\|2503111_2503414_+	hypothetical protein	A0A1C9EHP9	Gordonia_phage	3.5e-07	34.0
WP_113684249.1\|2503400_2503913_+	hypothetical protein	NA	NA	NA	NA
WP_113684248.1\|2503930_2504317_+	hypothetical protein	A0A023ZX24	Mycobacterium_phage	2.4e-08	35.0
WP_113684247.1\|2504331_2508207_+	hypothetical protein	A0A2H4P9V9	Gordonia_phage	9.9e-179	36.9
2505311:2505327	attR	NA	NA	NA	NA
WP_113684246.1\|2508218_2509142_+	hypothetical protein	A0A2H4JHX7	uncultured_Caudovirales_phage	2.0e-85	53.3
WP_154606673.1\|2509132_2510818_+	hypothetical protein	A0A142KBV3	Gordonia_phage	2.3e-156	49.1
WP_113684244.1\|2510817_2511186_+	DUF2744 domain-containing protein	G8I4D2	Mycobacterium_phage	2.4e-26	47.0
WP_113684243.1\|2511182_2512226_+	hypothetical protein	A0A159B6C4	Gordonia_phage	2.0e-86	46.5
WP_113684242.1\|2512222_2512471_+	Holin	A0A2H4PA17	Gordonia_phage	4.6e-05	46.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP046099

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection