CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP046257	Gordonia sp. 135 chromosome, complete genome	7 crisprs	csa3,cas3,DinG,WYL,cas4,DEDDh	0	3	5	0
NZ_CP046258	Gordonia sp. 135 plasmid pG135, complete sequence	0 crisprs	csa3	0	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP046257_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046257_1

905740-905801

Orphan

Consensus_repeat	Method
CCGTACTGGGGTGGCTGCTGCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046257_1

>merge|NZ_CP046257|1|905740-905801|CRISPRCasFinder
CCGTACTGGGGTGGCTGCTGCCCGAAGCCGGGCTGTTGACCGTACTGGGGTGGGGGAGGCGG

>NZ_CP046257|1|1|905740-905801|CRISPRCasFinder
CCGTACTGGGGTGGCTGCTGCCC	GAAGCCGGGCTGTTGA
CCGTACTGGGGTGGGGGAGGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046257.1\|WP_035751793.1\|913217_913934_+\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|234670
NZ_CP046257.1\|WP_006358492.1\|907662_908430_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235906
NZ_CP046257.1\|WP_035751811.1\|896719_897802_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|376764
NZ_CP046257.1\|WP_035751807.1\|901325_902825_-\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143457
NZ_CP046257.1\|WP_035751795.1\|910202_911582_-\|DNA-repair-protein-RadA	unknown	unknown	gnl\|CDD\|236994
NZ_CP046257.1\|WP_042376246.1\|909664_910195_+\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NZ_CP046257.1\|WP_035751799.1\|906014_906887_-\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|224115
NZ_CP046257.1\|WP_035751813.1\|895111_896692_+\|cytochrome-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|376587
NZ_CP046257.1\|WP_035751805.1\|902958_903594_-\|peptidase-S16	unknown	unknown	gnl\|CDD\|225362
NZ_CP046257.1\|WP_035751798.1\|906885_907536_+\|carbonic-anhydrase	unknown	unknown	gnl\|CDD\|239473
NZ_CP046257.1\|WP_155225014.1\|904037_904874_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP046257.1\|WP_006358497.1\|912699_913188_+\|CarD-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224248
NZ_CP046257.1\|WP_035751791.1\|913930_914395_+\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	unknown	unknown	gnl\|CDD\|178851
NZ_CP046257.1\|WP_006358496.1\|911665_912376_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046257.1\|WP_042376197.1\|892781_893960_-\|folate-binding-protein-YgfZ	unknown	unknown	gnl\|CDD\|223431
NZ_CP046257.1\|WP_155225013.1\|899504_901217_+\|thiol-reductant-ABC-exporter-subunit-CydC	unknown	unknown	gnl\|CDD\|274331
NZ_CP046257.1\|WP_035751815.1\|894034_894904_+\|aminodeoxychorismate-lyase	unknown	unknown	gnl\|CDD\|236114
NZ_CP046257.1\|WP_006358487.1\|903646_903955_-\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|225209
NZ_CP046257.1\|WP_051405860.1\|897798_899523_+\|thiol-reductant-ABC-exporter-subunit-CydD	unknown	unknown	gnl\|CDD\|274323
NZ_CP046257.1\|WP_006865342.1\|908474_909560_-\|DNA-integrity-scanning-protein-DisA	unknown	unknown	gnl\|CDD\|237395

Protein	Function_ID	Function_description	E-value
NZ_CP046257.1\|WP_035751793.1\|913217_913934_+\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	gnl\|CDD\|234670	PRK00155, ispD, D-ribitol-5-phosphate cytidylyltransferase.	1.08884e-73
NZ_CP046257.1\|WP_006358492.1\|907662_908430_+\|hypothetical-protein	gnl\|CDD\|235906	PRK07003, PRK07003, DNA polymerase III subunit gamma/tau.	7.23102e-05
NZ_CP046257.1\|WP_035751811.1\|896719_897802_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	gnl\|CDD\|376764	pfam02322, Cyt_bd_oxida_II, Cytochrome bd terminal oxidase subunit II. This family consists of cytochrome bd type terminal oxidases that catalyze quinol-dependent, Na+-independent oxygen uptake. Members of this family are integral membrane proteins and contain a protohaem IX centre B558. One member of the family, Klebsiella pneumoniae CydB, is implicated in having an important role in micro-aerobic nitrogen fixation in the enteric bacterium Klebsiella pneumoniae. The family forms an integral functional unit with subunit I, family Bac_Ubq_Cox, pfam01654.	4.9561e-109
NZ_CP046257.1\|WP_035751807.1\|901325_902825_-\|aldehyde-dehydrogenase	gnl\|CDD\|143457	cd07139, ALDH_AldA-Rv0768, Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like. The Mycobacterium tuberculosis NAD+-dependent, aldehyde dehydrogenase PDB structure, 3B4W, and the Mycobacterium tuberculosis H37Rv aldehyde dehydrogenase AldA (locus Rv0768) sequence, as well as the Rhodococcus rhodochrous ALDH involved in haloalkane catabolism, and other similar sequences, are included in this CD.	0
NZ_CP046257.1\|WP_035751795.1\|910202_911582_-\|DNA-repair-protein-RadA	gnl\|CDD\|236994	PRK11823, PRK11823, DNA repair protein RadA; Provisional.	0
NZ_CP046257.1\|WP_042376246.1\|909664_910195_+\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	9.08687e-17
NZ_CP046257.1\|WP_035751799.1\|906014_906887_-\|A/G-specific-adenine-glycosylase	gnl\|CDD\|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	6.54928e-95
NZ_CP046257.1\|WP_035751813.1\|895111_896692_+\|cytochrome-ubiquinol-oxidase-subunit-I	gnl\|CDD\|376587	pfam01654, Cyt_bd_oxida_I, Cytochrome bd terminal oxidase subunit I. This family are the alternative oxidases found in many bacteria which oxidize ubiquinol and reduce oxygen as part of the electron transport chain. This family is the subunit I of the oxidase E. coli has two copies of the oxidase, bo and bd', both of which are represented here In some nitrogen fixing bacteria, e.g. Klebsiella pneumoniae this oxidase is responsible for removing oxygen in microaerobic conditions, making the oxidase required for nitrogen fixation. This subunit binds a single b-haem, through ligands at His186 and Met393 (using SW:P11026 numbering). In addition His19 is a ligand for the haem b found in subunit II.	0
NZ_CP046257.1\|WP_035751805.1\|902958_903594_-\|peptidase-S16	gnl\|CDD\|225362	COG2802, COG2802, Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only].	4.05176e-28
NZ_CP046257.1\|WP_035751798.1\|906885_907536_+\|carbonic-anhydrase	gnl\|CDD\|239473	cd03378, beta_CA_cladeC, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	6.81944e-67
NZ_CP046257.1\|WP_155225014.1\|904037_904874_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	3.44176e-20
NZ_CP046257.1\|WP_006358497.1\|912699_913188_+\|CarD-family-transcriptional-regulator	gnl\|CDD\|224248	COG1329, COG1329, Transcriptional regulators, similar to M. xanthus CarD [Transcription].	3.22404e-65
NZ_CP046257.1\|WP_035751791.1\|913930_914395_+\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	gnl\|CDD\|178851	PRK00084, ispF, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed.	6.38981e-74
NZ_CP046257.1\|WP_042376197.1\|892781_893960_-\|folate-binding-protein-YgfZ	gnl\|CDD\|223431	COG0354, COG0354, Predicted aminomethyltransferase related to GcvT [General function prediction only].	1.26687e-60
NZ_CP046257.1\|WP_155225013.1\|899504_901217_+\|thiol-reductant-ABC-exporter-subunit-CydC	gnl\|CDD\|274331	TIGR02868, ABC_transporter_ATP-binding_protein, thiol reductant ABC exporter, CydC subunit. The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex.	8.5128e-132
NZ_CP046257.1\|WP_035751815.1\|894034_894904_+\|aminodeoxychorismate-lyase	gnl\|CDD\|236114	PRK07849, PRK07849, aminodeoxychorismate lyase.	5.23517e-131
NZ_CP046257.1\|WP_006358487.1\|903646_903955_-\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|225209	COG2329, COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only].	5.22393e-27
NZ_CP046257.1\|WP_051405860.1\|897798_899523_+\|thiol-reductant-ABC-exporter-subunit-CydD	gnl\|CDD\|274323	TIGR02857, transport_ATP-binding_protein, thiol reductant ABC exporter, CydD subunit. The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex. Unfortunately, the gene symbol nomenclature adopted based on this operon in B. subtilis assigns cydC to the third gene in the operon where this gene is actually homologous to the E. coli cydD gene. We have chosen to name all homologs in this family in accordance with the precedence of publication of the E. coli name, CydD.	1.50462e-151
NZ_CP046257.1\|WP_006865342.1\|908474_909560_-\|DNA-integrity-scanning-protein-DisA	gnl\|CDD\|237395	PRK13482, PRK13482, DNA integrity scanning protein DisA; Provisional.	0

>NZ_CP046257.1|WP_155225014.1|904037_904874_+|alpha/beta-fold-hydrolase
MFDSHAIGEIGFRDHGGPVIVDDARGPLDGGTTTRPIVLLHGLMGRGRTWRRQVPWLRRYGRVFTYDAAFHTGADVEEPDSATELATERFVADLAEILTWIDRGPAVLIGHSMGALHAWCTAAAYPELVAALVVEDMAPDFRGRTTTNWTPWFESWPERFDSVDDAVAMFGPVAGRYFYEAFDDGRLHGRIPLWGAIADEWGVRDFWAEWEEVAVPSLVIEAEYTVTPPGQMRRMYEVNEHAQYLRVEGAGHLVHDDAPHVYRGAVEAFLSGLDTCPE
>NZ_CP046257.1|WP_006358487.1|903646_903955_-|antibiotic-biosynthesis-monooxygenase
MAVVKINAITVPEGAGPELEKRFANRAHSVDGSKGFLGFQLLRPVKGDDRYFVVTQWESEEDFQAWASGPAREAHAGERAKPVASGADLLEFEVVLDARPRA
>NZ_CP046257.1|WP_035751805.1|902958_903594_-|peptidase-S16
MFPLGTALLPGGELPLRVFEPRYRQMVGDHIEESDGRSTVRFGVVLIARGSEVGGGEVRCEVGTMTLADVTDRFPDGRALLSGTGTHRFRIVEWLPDDPYPLARIEVLSEPAPSEVDLERLHSIDQRLRVIMRQTLEAAGKDVDTIFAALDIIDADPAMADISPLYRWANRLQVEPHDQQRLLEAADPSGQLDVLDDVMEGLEARAAFGRG
>NZ_CP046257.1|WP_035751807.1|901325_902825_-|aldehyde-dehydrogenase
MTETVESHTATVTGGGDQPQLLIGGRWVDPHSSETLEVFSPATGERVGSVPHADATDVDTAVGAARAAFDSGVWSSTPPAQRADIIAKVADLIDERGDEITALVSAEMGAPPSAIATLQQLPGTGVLRAYANAARDYQWEEYRTGLFGTTRITREPVGVVGAICAWNVPLFITCNKMGAALAAGCSVVLKPAPETPLTGNYVAQLFIEAGVPAEAISVVTGGTETGQALVAHPDVDKITFTGSTAAGKAIGAACAETLKRCSLELGGKSAAIVLDDVDIAANAFMLTFLGLFNTGQACVAQTRILVPRSRQDEIVAAMVEAAKAMKVGLPSDPEAQLGPLITEKQRQKVEEYIELGKKAGATPVLESERPAGLDSGHFLTPTIFTGVTNDMAIAQEEIFGPVLSVIAYDDVDEAIAIANDSDYGLAGTVWTNDVERGIEISTKIRTGTFGINWYAIDPESPFGGYKNSGIGRENGREGLESFLEHKSTMLPMGYEVSSN
>NZ_CP046257.1|WP_155225013.1|899504_901217_+|thiol-reductant-ABC-exporter-subunit-CydC
MRDDPLIRALGFLGLRRGAVAKALLLGVGGSLSALGLAALSAWLITRAWQMPPVLYLSVAITAVRALGISRGLFRYLERLATHDLALRAMTTARERVYTALATGSPAYSVTLRRGDLLTRTGDDIDEIGNALIRGLIPIGVGVTTAVAAVVVMALVSLPAAAVLAVALVISGGVAPWLAARGGASTLRDGSRAATESAEATTTTLGHASELVVARRRGELLETAADADRRHLAATDRGRRLEAAAAAATPLAMGASLVAACVIAIQLASQTTGSLAGIASGEGLTPMILGVLVLLPLSAFESTAPLTEAGLQIERSRQSAARVMALVDGAHAADGTGPSGADVAVHRGMVEVSTDGLRWGRAERNVLGPEDGLDLDLRPGSRLAVVGPSGVGKSTLLLTLAGLLDPVDGDITCVDTSSRGPVELRSAGCYFAEEAHLFSTSVRENMRVARGDATDEEILAALTTVGLDGWAARLPDGLDTTLTGGADAVSGGERRRLLLARALLHPAPMVLLDEPTEHLSADDAAGLLRRLLGVEDDLFGPDRIVVVVTHQLPADVGDARVVELAPVAAH
>NZ_CP046257.1|WP_051405860.1|897798_899523_+|thiol-reductant-ABC-exporter-subunit-CydD
MTPLERSAATRRGAARPPVDPRLLRYSPTTRRYVAVTAAFAVAQVIAIIVAAGTAASILSELIVFPEERSFDAQWVHLVVLAVAMAARAAMAYGHDRYAHRAAEQAIAELRAEALDVLTDPRRTAPRTLLTLREHAATVLLRGLDALGPYLSGYLPALVAAVILTPTVTVVIAFADWPSALIILITLPLIPIFMVLVGLMTRDRTSRKLATMSRLTAQLLDLIAGLPTLRALNRAEAPAAQVAELGEAHRRSTMSSLRVAFLSGAVLELLATLCVALVAVGIGLRLVFGEMSLYAGVFALILAPEAYLPLRRVGAQFHNSADGVTAAGEVFELIDSPEDAAPMPVSGGRGITVAGAPITILDLGVHGRDGWAPESLRATIAPGSLTLFTGPNGSGKSTTLAAIMGLVTPDDGSVLIGSIPVTHADPESLYEQIAWLPQQPVVVPGTVGENVELFGALDRDAADRAATASGFDSVVLELPNRLDTRLGAGGVGLSAGQRQRLALTRVLASPAPLLLLDEPTAHLDEDSERAVLTALRERARAGDTVIVVAHRGIAREFADQVVEFDGGVPCATTH
>NZ_CP046257.1|WP_035751811.1|896719_897802_+|cytochrome-d-ubiquinol-oxidase-subunit-II
MGLPEVWFLIIAVLFVGYFVLEGFDYGVGMLMPFLGRSHTGGDARVASDEPAADPDTRRRVLLNTIGPVWDGNEVWLITAGGALFAAFGGWYATMFSAFYFALFLILIGLITRVCAIEWRGKIDNPRWRMWCDVGIGLGSWIPAIVWGIAFANVVRGLPIDADAQYTGGFFDLFNPYALLGGLTTLLAFLTHGAVFLSLKTDGALREDSMRYASRLSIPALVVAGAFLLWTQFAYGSAWTWIPVLTAAVAALVMVGATQVRKEGLAFAATSIAIVGTVAALFGSLYPDVLPSTINPAYDLTIDNTSSSHYTLVVMTWAAVLVTPVVIAYQAWTYWVFRKRLSVEIMPKPAGLRSLRAFGE
>NZ_CP046257.1|WP_035751813.1|895111_896692_+|cytochrome-ubiquinol-oxidase-subunit-I
MDALDVSRWQFGITTVYHFILVPLTIGLAPMIAVMQTVWHVTGNEQWLRATKFFGKLFLINFALGVATGIVQEFQFGMNWSEYSRFVADVFGAPLAMEGLVAFFLESTFIGLWIFGWDRLPRRVHLACIWLASIGVIASAYFIIAANSWMQHPVGVVWDDTRDRPRMNDFWAVITNSTTLAAFPHVIAGAFLTAGTFVAAIGCWWMARNMWRAKKLRVAIDTGDTSEMPKTTSPSHIDATPEDLELDARRFWRPVTRLALWIVIASGVGLFITGDIQSQIMFNQQPMKMAAAESLCETQTGAGFSVLAIGRQNNCDNIEHVIEIPKMLSFLADHSFDSTLQGVEELQQQYTEALAGQPGVPAGQNFAPNLFVTYWSFRAMITWALGSVVVALGGLWLTRRKRVVESRKFGTLALWMIPTPFLANSSGWIFTEMGRQPWVVAPNWENDLDPMRINMLVQNGVSNHSAATVWVTLIGFTLLYGALGVVWFMLQRRYVIEGPATYDSRPPGHSDPDADSGEPKQLSFAY
>NZ_CP046257.1|WP_035751815.1|894034_894904_+|aminodeoxychorismate-lyase
MSDSILLTLDGTQHDADAPFLHADDLAAVRGDGVFETLLVRAGRARGVRLHLERLARSATAMELPAPDPDEWRAAVENAVKLWTAEHGTSDEALLRLVYTRGREHGYAPTAYLTVERVPERVASARADGVSVVTLDRGFSIDLAARAPWQLLGAKTLSYATNMAALRHAASEGYDDVIFVSSEGAVLEGPRSTVVAVYGDSLVTPPTEIGILASTTAQAVFDLADAEGWKTKVEILRPEDLVAADSVWLVSSVTLAARVTHLNRYVMPVPADADRFSDLVDRAIAAEDN
>NZ_CP046257.1|WP_042376197.1|892781_893960_-|folate-binding-protein-YgfZ
MSRSPILTRHSEGGAVPGPGEFHSSETPWHFGDPLGEQRAAATGVIVVDRSDRAVVEIPGEERLSWLHTISSQHVAALPDRRSAENLSLDANGRVEEHFVLTDIDGVTWVDTEGVRGEALAGFLAKMVFWAKAQPAPRTDMKVLTLVGPGAVTGPVVELLEIPADADVYQAGNLPETHHEDEPLGFWRRMPPLGENRDLPVVDLVLPEFVLLRWWDALVEAGARMAGSWAYDALRVAARRPRLGADTDERTIPHEVDWIGGPAEQGAVHLDKGCYRGQETVARVHNLGKSPRRLVLLHLDGSSDQRPTTGDPVTAGGRTVGRLGTVIDHYEWGPIALALVKRNVGADVELTIGAEEPLSARIDPDSVREDDHVQAGRAAVERLRSGSATPGT
>NZ_CP046257.1|WP_035751799.1|906014_906887_-|A/G-specific-adenine-glycosylase
MTNSVPPERLIGWFGTHERDLPWRDPACTGWQILVSEIMLQQTPVSRVLEPWRMWVERWPVPSAMAVEPAGEVLRAWGKLGYPRRALRLHECSKVLARDHGDRVPDDVETMLTLPGIGDYTARAVACFAYGRAVPVVDTNVRRVIARAVHGREQPGNPSRRDLDDAEALLPRSGAPRFSAALMELGALVCTARNPKCDNCPLVDCTWVRRGRPAHTGPPRKAQKFAGTDRQVRGLLLDVLRGTTGSVDRAKLDVVWTSDTAQRDRALDSLLVDGLVEITTDGRYCLAGEG
>NZ_CP046257.1|WP_035751798.1|906885_907536_+|carbonic-anhydrase
MIGKTPREAWRVLRNGNDRFVAGESQHPSQGIEDRARLADGQHPHVVLFGCADSRLAAEIIFDQGLGDMFVVRTAGHVIDSAVMGSLEYAVEVLDVPLIVLLGHDSCGAVKATLDALDDLQIPGGYIRDVVERVTPSILAGRSEGLTRVDEFEARHVVETGRLLMQRSRIIADRISTGRLAIVGLTYKLSEGRVSLQGVYGDIGEQPQAHVVAETA
>NZ_CP046257.1|WP_006358492.1|907662_908430_+|hypothetical-protein
MIEPQGPLPPEIYWRRRVVAGGAALVVVGLVVALIVWMTSGGDAPQNTAATSSVPSSAAPSSESAPPSSEPPAAGDAGAGGAPGGNAAGAGAPGGASASASSPPESASPAGVPGGPAGPNLCPDQAISVVLYTDKPTYTIGQQPVFTIVTTNAGLSDCTRDVGKAAQNVIVRTLDGSRTLWSARDCSPIETVNNVVLKPAQQVKDTITWSGTTSSPGCERPRTQVPAGSYSAIGKIGERESFPITFNVVAPAQEP
>NZ_CP046257.1|WP_006865342.1|908474_909560_-|DNA-integrity-scanning-protein-DisA
MVAEVVKSELTRETLARVAPGTPLRDGLERILRGGTGALIVLGHDSDVEKICDGGFHLDVEFAPTRLRELAKMDGAVVLSTDGKRIVRANVQLVPDPSIPTEESGTRHRNAERTAIQTGHPVISVSASMSIVSVYVDGARRVVESPDPILSRANVALATLERYKARLDEVIAALSRAEIEDYVLLRDAMSTAQRMEMVRRVSVEIEEYVLELGTNGRQVSLQLEELISDNDTMRELLVRDYYASPEPATAEDVRQALEVIEGLSDADLLDLTQLAGAFGYPTTIDAQDNAMSPRGYRLLARISRLQFAHVDRLVRSFGTLQALLASTSADLQAVEGIGSIWARHIREGLSRLAETSIERYD
>NZ_CP046257.1|WP_042376246.1|909664_910195_+|PaaI-family-thioesterase
MPDELDVLERHPKTSEPGELMRPHNMTCFGCGPESPHGLHLEMYAGEGFSVDAKMPVQQWMEGGPGVIHGGILSSAFDDVMGMTPRLIGPAAVTAHLQVDFLQPIPVGKTLHLHAEILGKQRRKIYVEGVAHLGDPDRPVARANGLFVQIDVRAHFADHVENSAKAAEYLGGKPQL
>NZ_CP046257.1|WP_035751795.1|910202_911582_-|DNA-repair-protein-RadA
MAKPKSSYRCTGCGHQVAKWVGRCPECSEWGSIDEVAGAPTSSRTTAAVAPSSPALRITEVDAQSTAAVPTGIGELDRVLGRGVVPGSVILLAGEPGVGKSTLLLETVKHWAAQDRVALYITGEESAGQVRMRAERTGAVHANVYLAAETDLATILGHVDTVRPSLMIIDSVQTVVASGADGVTGGVTQIRAVTTALVSLAKDRGIAVILVGHVTKEGAVAGPRSLEHLVDVVLAFEGDKHSTLRMVRGVKNRFGAADEVGCFEQRDDGIHQVPDPSGIFLHQRDSDVSGSVTMVTMDGKRALVGEVQALANGTEMSNPRRAVSGLDFNRVAMVLAVLQARAGRKELGKSEVYLSTVGGMRVTEPAADLAIALSVYSTLTQRPVPQSTVVIGEVGLGGEIRRVSAVARRLAEAKRLGFREAIIPAATDEELPKGIRILRVANLGDAVHLRDSDPVDAPF
>NZ_CP046257.1|WP_006358496.1|911665_912376_-|hypothetical-protein
MLPLSARRSAVRPSRLATAAATIGIAVALGTTGCGAGQISQTANQLPAVNGANVNIDTLQLRDVQILYPEKDAPTVFGNGGPFELAFVVANSDQTAYYRLKEIKPEKGSVEFVEGSDSAARVIAPGQALSSGTPVGSVRDSEKKVTAELTNAGDTVAAGLTTDLTFVFEKREGNGSWVPAGETTVQTPVDAGAELERQDVARNAEPTFYNQHHGAVGPGDSEGGTPETGHEEGGGH
>NZ_CP046257.1|WP_006358497.1|912699_913188_+|CarD-family-transcriptional-regulator
MNFKVGDTVVYPHHGAARVEDIVTRTIKGEQIEYLVLKVADGDMTVQIPSTKLEYVGVRDVVGQEGLDQVFQVLRAPHTEEPTNWARRFKANQEKLISGDIIKVAEIVRDLWRREQDRGLSAGEKRMLTRARRVLVDELSLAQNTDDEKATIILDEVLAAAS
>NZ_CP046257.1|WP_035751793.1|913217_913934_+|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase
MTTTPEDSGAEVCVIIPAAGSGTRLGEPVPKAFVDLDGATIIERCVDNIPESLGASIVVVVPADLVEHARELLPGVAVVPGGAHRSDSVRAGIAAAGDARILLVHDAARPLTPAHVFTRVVDAVAAGHPAVVPGVPVVDTLKQVAPDASGHELVTRTVDREELRAVQTPQGFTREALLRAHADDSGLATDDAGLAERCGIPVHIVPGDPLAMKITTPWDLRIIRDVVRETAADAEARS
>NZ_CP046257.1|WP_035751791.1|913930_914395_+|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase
MRVGIGTDAHRIDASADCWMVGLHFPDEPGCEGHSDGDVGAHALCDAVLSAAGLGDVGSVFGTGRPEWEGVSGIAMLTHVAELIADEGLRVVNAAVQVIGNRPKIGPRRAEAQEVLSAAVGGPVSVSATTTDGLGMTGRGEGIAAVATALLDDA

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Crispr_ID: NZ_CP046257_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046257_2

1131416-1131702

Orphan

Consensus_repeat	Method
GCCGTCGCCGTCGGTGTCGAGGA	CRISPRCasFinder

5 spacers

The CRISPR arrays of NZ_CP046257_2

>merge|NZ_CP046257|2|1131416-1131702|CRISPRCasFinder
GTCGCCGCCGTCGATGCTGCCGAAGTCGCCGACCTCGACGTTGCCCTCGTCGTCGACCGCGGTGTCGAAGGTGCCGTCGCCATCGGTGTCGGCGACCGCGAGGTCGGTGTAGCCGTCTCCATCGGTGTCGGCCTCGATGACGTCGATCTCGCCGTCGGAGTCGGTGTCGTAGGCGATGGAATCGGCCTGGCCGTCGCCGTCGGTGTCGAGGACGGCGTCGGTGACGCCGTCGCCGTCCACGTCGGTCAGGGCGGCGTCGATGGTGCCGTCGCCGTCGGTGTCGACGA

>NZ_CP046257|2|2|1131416-1131702|CRISPRCasFinder
GTCGCCGCCGTCGATGCTGCCGA	AGTCGCCGACCTCGACGTTGCCCTC
GTCGTCGACCGCGGTGTCGAAGG	TGCCGTCGCCATCGGTGTCGGCGACCGCGAGGTCGGTGTA
GCCGTCTCCATCGGTGTCGGCCT	CGATGACGTCGATCTC
GCCGTCGGAGTCGGTGTCGTAGG	CGATGGAATCGGCCTG
GCCGTCGCCGTCGGTGTCGAGGA	CGGCGTCGGTGACGCCGTCGCCGTCCACGTCGGTCAGGGCGGCGTCGATGGT
GCCGTCGCCGTCGGTGTCGACGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046257.1\|WP_035753399.1\|1140222_1140777_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046257.1\|WP_155225048.1\|1138341_1138785_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046257.1\|WP_006358256.1\|1132517_1132889_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046257.1\|WP_035753262.1\|1117875_1118778_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046257.1\|WP_075862945.1\|1138781_1139675_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP046257.1\|WP_050918658.1\|1139668_1140211_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372273
NZ_CP046257.1\|WP_155225045.1\|1128942_1129314_-\|glyoxalase	unknown	unknown	gnl\|CDD\|319924
NZ_CP046257.1\|WP_155225046.1\|1134534_1136370_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366045
NZ_CP046257.1\|WP_042375546.1\|1126675_1127668_-\|alpha/beta-hydrolase	unknown	unknown	unknown
NZ_CP046257.1\|WP_042375549.1\|1119125_1122614_+\|DNA-directed-RNA-polymerase-subunit-beta	unknown	unknown	gnl\|CDD\|234749
NZ_CP046257.1\|WP_006358244.1\|1115857_1117099_+\|MCE-family-protein	unknown	unknown	gnl\|CDD\|273384
NZ_CP046257.1\|WP_042375435.1\|1122652_1126609_+\|DNA-directed-RNA-polymerase-subunit-beta'	unknown	unknown	gnl\|CDD\|234794
NZ_CP046257.1\|WP_006358257.1\|1133105_1134500_+\|GTPase	unknown	unknown	gnl\|CDD\|206739
NZ_CP046257.1\|WP_075862948.1\|1131960_1132515_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|236608
NZ_CP046257.1\|WP_075862950.1\|1129432_1130311_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380141
NZ_CP046257.1\|WP_006358245.1\|1117192_1117876_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046257.1\|WP_155225049.1\|1140918_1143231_+\|phosphoenolpyruvate-synthase	unknown	unknown	gnl\|CDD\|235809
NZ_CP046257.1\|WP_035753253.1\|1127667_1128891_-\|glutaminase-A	unknown	unknown	gnl\|CDD\|377427
NZ_CP046257.1\|WP_075862949.1\|1130398_1131337_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|377306
NZ_CP046257.1\|WP_155225047.1\|1136425_1138216_+\|Hsp70-family-protein	unknown	unknown	gnl\|CDD\|212667

Protein	Function_ID	Function_description	E-value
NZ_CP046257.1\|WP_155225047.1\|1136425_1138216_+\|Hsp70-family-protein	gnl\|CDD\|212667	cd10170, HSP70_NBD, Nucleotide-binding domain of the HSP70 family. HSP70 (70-kDa heat shock protein) family chaperones assist in protein folding and assembly and can direct incompetent "client" proteins towards degradation. Typically, HSP70s have a nucleotide-binding domain (NBD) and a substrate-binding domain (SBD). The nucleotide sits in a deep cleft formed between the two lobes of the NBD. The two subdomains of each lobe change conformation between ATP-bound, ADP-bound, and nucleotide-free states. ATP binding opens up the substrate-binding site; substrate-binding increases the rate of ATP hydrolysis. HSP70 chaperone activity is regulated by various co-chaperones: J-domain proteins and nucleotide exchange factors (NEFs). Some HSP70 family members are not chaperones but instead, function as NEFs to remove ADP from their HSP70 chaperone partners during the ATP hydrolysis cycle, some may function as both chaperones and NEFs.	7.46733e-74
NZ_CP046257.1\|WP_075862945.1\|1138781_1139675_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	5.83552e-24
NZ_CP046257.1\|WP_050918658.1\|1139668_1140211_+\|hypothetical-protein	gnl\|CDD\|372273	pfam12724, Flavodoxin_5, Flavodoxin domain. This is a family of flavodoxins. Flavodoxins are electron transfer proteins that carry a molecule of non-covalently bound FMN.	2.81579e-18
NZ_CP046257.1\|WP_155225045.1\|1128942_1129314_-\|glyoxalase	gnl\|CDD\|319924	cd07263, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	6.37028e-18
NZ_CP046257.1\|WP_042375549.1\|1119125_1122614_+\|DNA-directed-RNA-polymerase-subunit-beta	gnl\|CDD\|234749	PRK00405, rpoB, DNA-directed RNA polymerase subunit beta; Reviewed.	0
NZ_CP046257.1\|WP_006358244.1\|1115857_1117099_+\|MCE-family-protein	gnl\|CDD\|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	2.67886e-43
NZ_CP046257.1\|WP_042375435.1\|1122652_1126609_+\|DNA-directed-RNA-polymerase-subunit-beta'	gnl\|CDD\|234794	PRK00566, PRK00566, DNA-directed RNA polymerase subunit beta'; Provisional.	0
NZ_CP046257.1\|WP_006358257.1\|1133105_1134500_+\|GTPase	gnl\|CDD\|206739	cd09912, DLP_2, Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins. The dynamin family of large mechanochemical GTPases includes the classical dynamins and dynamin-like proteins (DLPs) that are found throughout the Eukarya. This family also includes bacterial DLPs. These proteins catalyze membrane fission during clathrin-mediated endocytosis. Dynamin consists of five domains; an N-terminal G domain that binds and hydrolyzes GTP, a middle domain (MD) involved in self-assembly and oligomerization, a pleckstrin homology (PH) domain responsible for interactions with the plasma membrane, GED, which is also involved in self-assembly, and a proline arginine rich domain (PRD) that interacts with SH3 domains on accessory proteins. To date, three vertebrate dynamin genes have been identified; dynamin 1, which is brain specific, mediates uptake of synaptic vesicles in presynaptic terminals; dynamin-2 is expressed ubiquitously and similarly participates in membrane fission; mutations in the MD, PH and GED domains of dynamin 2 have been linked to human diseases such as Charcot-Marie-Tooth peripheral neuropathy and rare forms of centronuclear myopathy. Dynamin 3 participates in megakaryocyte progenitor amplification, and is also involved in cytoplasmic enlargement and the formation of the demarcation membrane system. This family also includes mitofusins (MFN1 and MFN2 in mammals) that are involved in mitochondrial fusion. Dynamin oligomerizes into helical structures around the neck of budding vesicles in a GTP hydrolysis-dependent manner.	1.85722e-11
NZ_CP046257.1\|WP_075862948.1\|1131960_1132515_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|236608	PRK09652, PRK09652, RNA polymerase sigma factor RpoE; Provisional.	9.77357e-40
NZ_CP046257.1\|WP_075862950.1\|1129432_1130311_+\|hypothetical-protein	gnl\|CDD\|380141	pfam18741, MTES_1575, REase_MTES_1575. Vsr REase Fold. Fused to HEPN (SWT1/Abi2 family), along with Transglutaminase and wHTH.	1.16799e-07
NZ_CP046257.1\|WP_155225046.1\|1134534_1136370_+\|hypothetical-protein	gnl\|CDD\|366045	pfam00350, Dynamin_N, Dynamin family.	1.6986e-14
NZ_CP046257.1\|WP_035753253.1\|1127667_1128891_-\|glutaminase-A	gnl\|CDD\|377427	pfam04960, Glutaminase, Glutaminase. This family of enzymes deaminates glutamine to glutamate EC:3.5.1.2.	3.72312e-145
NZ_CP046257.1\|WP_075862949.1\|1130398_1131337_-\|ATP-binding-protein	gnl\|CDD\|377306	pfam04326, AlbA_2, Putative DNA-binding domain. This family belongs to the AlbA clan of DNA-binding domains.	1.80954e-19
NZ_CP046257.1\|WP_155225049.1\|1140918_1143231_+\|phosphoenolpyruvate-synthase	gnl\|CDD\|235809	PRK06464, PRK06464, phosphoenolpyruvate synthase; Validated.	0

>NZ_CP046257.1|WP_075862949.1|1130398_1131337_-|ATP-binding-protein
MRTDLSKLADPDRGNIGSLEFAIPVWATATALVLVLMVAWLFGSVAKWLLRRRARLNTTTCMVLSIVGTAVGLFIAGAVDHRMDIWSPVTIVLGLVSSIVAVGAYALIAARLQTPTDISVAEILESGESERVEFKSTARMNLRTKQRDPALEAVIVKTVAAFLNSDGGNLLIGVDDDGTPLGLDADFTLLRQPDADRFELWLRDLLTTMLGQSTAAEVGISFEKMARPSGDADSEGPAEALVCRVECTPSPRPVYLRGTKNNAVPEFWVRAGNSSRQLNVDQAAEYVMYRWPLGVGRAVAAQVQAAVRFSAV
>NZ_CP046257.1|WP_075862950.1|1129432_1130311_+|hypothetical-protein
MSDCGVYPLSELLANGWSRAEVAEARRAGRLSSVAHGWVSAEGADDRAVSAVAAGGALSCISALRFHRTHGSEGIWVPPGYQETHVRRPKHRKSGARPTGPFRWCQGYGRPLPVVSAVDSIPIALGCAARCLEPEDWVATVDSILNQTQLTIPDIQADMGGVTKAVMELFGRCDARSQSGTESIARVRLVATGFKVAVQPSIGGHERADLRVGSLLIECDGRQYHSSAEAFRNDRRRDRMTLIDRWMTVRVTYDDVLYDWESVLEDIRAVTRPDRHRIRREEDPRRREIPSP
>NZ_CP046257.1|WP_155225045.1|1128942_1129314_-|glyoxalase
MNWTLEVVTLPVRDVDRTKAFYESIGFNPDHDHTVSEEIRFVQMTPPGSNCSIAFGKGLTDKVPGSTGPIIICVTDINAARDQLLVAGVDPGEVDVQPWGHFVYFADPDGNQWSVQYLPYRDN
>NZ_CP046257.1|WP_035753253.1|1127667_1128891_-|glutaminase-A
MRSPIDDYLHQVLQDCRDDDAGDVMSGNRELERADPSSFGIALATVDGAVYTAGDADHEFAMQSIAKLPAYALALRDRGLDGVLDRVDTEPSGDAFNEISLEAETGRPRNALINAGAIAVHGMVDGDSATERVDRIADLVSTLAGRELSIDNDVHSAELASDDHNTALAYLLRSAGKLEYEPDEVVDGYAAQCAIKVSCRDLAIMGSVLANGGLSTTNDDESLLEGWITRHLLSVMATCGMYDGSGSWMAKVGIPAKSGVSGAILGVLPGQVGVAVWSPRLDEQGNSVRGVAVFERLSHDMELHMMHVAPSGMPALRSVHEDNGATVVELQGDVRFAGAEIIASRACEGFSTDKVIIDLTHVRVMDDAARGLLREVAKRLGDDHDTHIEDPNELMDEGPDDQDTDEK
>NZ_CP046257.1|WP_042375546.1|1126675_1127668_-|alpha/beta-hydrolase
MNPTRFRVPWIATLAAIVVLLGVTPASVPAAPATRPVDVSSSVATECAGKPVRVDARWYFPAGRPTALVWLQHGFSRSAANLDALARSYANSGFLVVSPTLDSVNLGGCAVAYNIADNAAFARTIGGVFGSGRDADSPLGASLVRARDAAHRPDVTMPYRMVFAGHSAGGEFVVVAADALRRTDPVAYRRLAGLMLFDPVNSFFGDHFSSAAASLGAERVPIRVIASQPSVSNSFESGVAVLERTTRQEFLGSRLVTGIHIDAEGESTDLIGELSELAVPRPRNGRVIRTLATGWSSDMVAGTVTPTYYPGGRYYDLLLSTRTVTTLPVR
>NZ_CP046257.1|WP_042375435.1|1122652_1126609_+|DNA-directed-RNA-polymerase-subunit-beta'
MLDVNFFDELKIGLATADDIHNWSYGEVKKPETINYRTLKPEKDGLFCEKIFGPTRDWECYCGKYKRVRFKGIICERCGVEVTKAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLAPKDLEKIIYFAAYVITAVDDELRHNELSTLEAEMEVEKKAVADQRDADLNERQQKLEQDLAELEAEGAKADVRRKVRDGAEREMRRMRDSAQRELDGLEEIWDKFVKLAPGDLIIDEKLYRQLEERYGEYFQGSMGAEAIKKLLETFDIDAEAESLRETIRSGKGQKKLRALKRLKVVAAFQQSGNSPLGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLIDLGAPEIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPLKSLSDLLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKLMALELFKPFVMKRLVDLNQAQNIKSAKRMVERQRPAVWDVLEEVISEHPVLLNRAPTLHRLGIQAFEPQLVEGKAIQLHPLVCEAFNADFDGDQMAVHLPLSAEAQAEARILMLSSNNILSPASGRPLAMPRLDMVTGLYYLTSLKEGAEGEYTPATADDIERGVYSSPAEAIMAVDRGQLTVQSRIRVRLTGQRPPAEVEAELFPEGWRFGQPWTTITTLGRVLFNELLPIEYPFVDEQMPKKRQAAIINDLAERYPMIVVAQTVDKLKDVGFYWATRSGVTVSMADVLVPPQKAEILDRYEERADGLERKFQRGALTPDERRDALVEIWKQATEEVGKAMEEYYPEDNPIIMIPKSGATGNLTQVRNLSGMKGLVTNPKGEFIPRPIKSSFREGLTVAEYFINTHGARKGLADTALRTADSGYLTRRLVDVSQDVIVRETDCGTERGINVPLGEKQPDGSIIRDAHVETSAYARTLAADAVDADGNVVVERGHDLGDPAIEALLAAGIAQVKVRSVLTCATGTGVCAHCYGRSMATGKLVDIGEAVGIIAAQSIGEPGTQLTMRTFHQGGVGDDITGGLPRVQELFEARVPKGVAPIAEVSGRIRLEDDDRFYKITIIPDDGSEEVVIDKISKRQRLRVFKHDDGTERLLADGDHVEVGQQLMEGSANPHEVLRVMGPRQVQIHLVNEVQEVYRSQGVSIHDKHIETIVRQMLRRVTIIDHGATEFLPGSLVERAEFEAANRQVVTEGGEPAAGRPVLMGITKASLATESWLSAASFQETTRVLTDAAINSRSDKLIGLKENVIIGKLIPAGTGINRYRNIQVQPTEEARAAAYAVPSYDDTYYSPDGTFGAPAGAAVPLDDYGFSNEYR
>NZ_CP046257.1|WP_042375549.1|1119125_1122614_+|DNA-directed-RNA-polymerase-subunit-beta
MAVNRQSTSTIPGAPHRASFAKISEPLEVPGLLDLQLDSFEWLVGSPEWRAKAIARGEENPTGGLEDILHELSPIEDFSGSMSLSFSEPHFDEVKASVEECKDKDMTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPIMTDKGSFIINGTERVVVSQLVRSPGVYFDAAIDKATEKTLHTVKVIPGRGAWLEFDVDKRDTVGVRIDRKRRQPVTVLLKALGFTTEEITERFGFSEIMMSTLEKDNTANQDEALLEVYRKLRPGEPPTKESAENLLENLFFKDKRYDLARVGRYKVNKKLGLTGNPMTGESTLTREDIIATVEYLVRLHEADPHTTTYMTVPGGVEVPVEVDDIDHFGNRRLRTVGELIQNQIRVGLSRMERVVRERMTTQDVEAITPQTLINIRPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVVDGVVTDEIQYMTADEEDRFLIGQANTNFDGSGRITDERVLVRKKGSEVEFVGATDVEYLDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVRNESPLVGTGMELRAAVDAGDVIVSSKTGVVEEVSADYITVMSDEGTRDTYRMRKFARSNHGTCANQRPIVDEGQRVEAGQVLADGPCTENGEMALGKNLLVAIMPWEGHNYEDAIILSQRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPNVSDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGETGKVIGVRVFSRDDDDDLAPGVNELVRVYVAQKRKIQDGDKLAGRHGNKGVIGKILPQEDMPFLPDGTPVDIILNTHGVPRRMNIGQILETHLGWIAKAGWNINVAEGVPEWASNLPEDMYSAEPDTNTATPVFDGAREEELTGLLSSTLPNRDGEVMVNGDGKATLFDGRSGEPFPYPVAVGYMYIIKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDVVGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLSSDGAAIEMHDTDDEDLERAAANLGINLSRNESATVDDLAN
>NZ_CP046257.1|WP_035753262.1|1117875_1118778_+|hypothetical-protein
MAQNPKKPAGKRRPTPKVAGHTRATQPGQTPDAPEVDASAPALPEVQGAKAAGPGERSESTSHEGSGDDTSSSVDAADTDTAPAKPDLTKPKTRPVSRVSTLRPSAAGRTDEDTSSNRPMGRPGRQGSAEGRKKRAAPLAAILAAAAVVLGIVAVVLAFHPGADVGPNKAFVDQEATSQLTGQAQERICAIFGYEHTELDAWQKRAQDALTGQAREEFDKTFKAQKDLITQTKTGAECRVDALGVKDLTGGGDGAHATVIANMIISETQNSMATNSGAPRAQFAMVKEGDTWRIQGVEPF
>NZ_CP046257.1|WP_006358245.1|1117192_1117876_+|hypothetical-protein
MTGTPEPTGSASTGSTDPDAGPTEKNTGTRPALRRLAGVAPLALAIVAVIAAVVCVAVFGVRAYDVYANQYPAQQTRDDATQAAEQAVLNITTIDPADLDGFRERAEASLTGKAKNEVLGGKDGSVLDMLSNAGPDAAKLSARLVRSAPSEVNPDEGKAKVLVYVITTLERPGQPGVDETRGFDVSMIKDGDTWKAENLLGLEGIAYADAGQSGNGQAPAPAPGGGN
>NZ_CP046257.1|WP_006358244.1|1115857_1117099_+|MCE-family-protein
MISKLVKIQLIVFVVVGLVALVYVGAKYARLDKLAGVGMYSVTAQLPDSGGIFTNAEVTYQGVPVGRVGGLTLTKSGVDVKLDIDKGGPDIPASATAVVASRSAIGEQYVDLQPTTSSGPYLKAGDVITKYQLPEPLEDVVKSAIDFTSSIPVDDLHTVITELGKAFNGQSENLTRLVDSLGKLSRAGVDNLPEVVSLIQDSNVVLATQADQSDAILTWSRNLDLVTATLASSDPDLRRLLTTGTLSATQISELIQKNGNDISKVVKDLAEVSRTIEPATYNISTTFAMLSALSAGSHSPAPGDGQIHFGVVLETNNPAACTRGYGGTDAIMAEMRRKNPNFDKHYDAFPFNTEAKCTVPLGNPTGVRSAERAKYANPAYPQPWDSTPKKDPDKLNLNPLAQQLAALLGVRPK
>NZ_CP046257.1|WP_075862948.1|1131960_1132515_-|sigma-70-family-RNA-polymerase-sigma-factor
MDTSEVHSLTDESDPGADLLEHARSGDPQAFTMLVEQHRDRLWAICLRITGNQHDAEDALQDALVAAWRAIGSFRGDAQVSTWLYRIGSNAALARIRKRSDADDIDDHDPVSSLDVAQQVVVSDRIQEALSQVPDAYRATFVLRVYGELSYSEIAEAQGIGLQTVRSRISRARSVLADLLADLR
>NZ_CP046257.1|WP_006358256.1|1132517_1132889_-|hypothetical-protein
MTDNTTSWDDPLDGDDFESWLRESDPPSELAVPATTWDSAVETAFDPSHELTEDLTAAPGPGPLDEESSDGSPDAELVGFDDDLGGDLDATLDTPDAFGSDDDAGDESFGGTTFDDSALGDDF
>NZ_CP046257.1|WP_006358257.1|1133105_1134500_+|GTPase
MEQHMTVRGRVEQLLDEVTPLAPDPALIGVLRAQLANPLTVALVGRVSAGKSTLLNALVGDRVAPTERAECTKVAALYTEGNPQRVEVVGLDGTVTESPGTIRGDLGRRPEDIDHAVVYTPSRLLRERFRVIDTPGLSGFTDTAEIATRRVFSGEGRLPRPDVILFLLDDAAGPKSDEVQFLADAGASAQNTILVISHADLIAADNPMLKAQEIARRVWRRFPAIAGAVVAVSGLMAEAGVCGVTERETAQISRRGLLESWELLTILDGAAPPPPGLDVDLLGRLEELVGTYAMDAGADVARQGARAYCEWLHRVSGIDELRLAIGRRFLAVGDILKARTALAELREAAYRATRRDAFLEAIEEAETAPELHRLREVAALEALARWQPDSDLIGELTLVVASRDVRLLLSLPPNAAPPQIADAAKERATDCRTRRAFAATSAEKEALLVLEQTYQLVRRGRWTT
>NZ_CP046257.1|WP_155225046.1|1134534_1136370_+|hypothetical-protein
MSLEKAPAKSAVPTPDATLRAAVDMLRKHGEDAIADRALRVTDRPAPQGTVVVIGEVSRGKSSLVNTLVGVNGLAPVDTEITTSVYVRFTPATEDLPVNSALIEFPGATHRIPVADLADWITVGGHYAAGVPAERLAPGTAVDSVLVPPVSARVGIDSPLLPGVTIVDTPGVGSLVPEHVEAAVSAARGASVLVMVCDATAPLSAPELAFLSSVSEEVASVVLVVTKTDLVMRQWRTIVAENRKLIGANAPRFAHIPIIGISNRIAEQAAAITDPERRERALAASGIPELVDALTPLVAEGAASPERNALQLTFAGLDDVRKRLVLEMKAATATPAERADIEAERDRLQRLKDRRREWRARLNQDITAASLQTDDLIRDRFDKLLGQWSTRIDKLRFYEPHRAGQELIGQMTVDLEAAAREVSAFFVAGIERIADNLFADATISGELVDRISGNVSDLKLREQEKISPWKNMVDPVLLSIVAAGGPLAIIPVVNVVAVPVWAGVVVGFRASKVGKENHRKWLTKAVNDMKADVRSQLQSIKSEASADLQIAYDELLERLLAESTKIINDAAVEAKKSAADREKTAADLRTRIVAVDNVRKAIARVLRAPTG
>NZ_CP046257.1|WP_155225047.1|1136425_1138216_+|Hsp70-family-protein
MTQESRRRLCIDFGTSNTAAAYRVGPAEPVIVPLGSGGPAMPSAVFADDGGIVVGHDAVRRRVQAPDAYEDSPKSRIDEGEIELGDRFWPIEDLIGAVLRHAHQTALRHSGLPEFDSIILTHPDKWSERRKGVLRRAAERAGISADRLRIASESLSAAWYYVYRGHDVTGDERMCVFDFGAGTCDVAVLIRAGADGFTVTGSGGDNNLGGRDLDARMTRWVLEEAAEIDPGLPARLRAPAAAIALADHVRSAKEALSDTAQAVIELPGTRHTLLLTRREFESMIAPFVERAVELTRDAIARADAAGTGPKGPVIVYVTGGTSSIPMLQSALSSVGRVARIGDPKVVVAQGGLLRSTNVDVHGAAAAQQYAARPTDPPMSATAVDASARRIAFPTVPPGTVITGVLARNGQVVRAGEPLATLDSPSGRLTVDAPVAGTLHGLDLRPGVVAQPGVVFGAVGAADLRPEQWSQLHRAPAGITAAQPAYAQPQPMYPPPQQRQPQSPYPPRQPGTPAAGHAGAHPVPASPGINTYALAGLILGILGFPICLGTIVGMALTVIGINRAEGGRDALLMTALGVNILGTIAWVVFLIWIFVTG
>NZ_CP046257.1|WP_155225048.1|1138341_1138785_+|hypothetical-protein
MTTSKSLSDHRVDARRRQVGYSVSIAVNAVLLVALLGWPGWESVPFLTDDFGRIIGWVVAALVAGIVANAMYLIADPPIVEMIGELAIDTFGLIALVRLSQVFPFDFGDSGIPWSTVARVVLAVGIAGTAIAMVVVIVQTALRRRSP
>NZ_CP046257.1|WP_075862945.1|1138781_1139675_+|universal-stress-protein
MTDSTAPIVVGVDGSDCALMAVRWAAAAASRENRPLRVLSAVGIFPGAYAPTAMMTSDVVVEAMQSDARRAVEAGTAVAKETAPDVPVDGTVVGGSPVLALRHASAQAHSLVVGRRGVGGVRGLLLGSVSNDAAIHAECPVIVVGGPTPTAGPVVVGVDGSPTSTAAIGHAFRQADLLQTSLLAVHTFGGFSGTAFYGDQHQIIRQLRDEAEELLGEQLAGYPEDYPDVKIERRVEIGSPADALVDAAETAQLVVVGTRGRGGIRGLLLGSTSRAVLQVAQCPVMVTHTAPLTRRSW
>NZ_CP046257.1|WP_050918658.1|1139668_1140211_+|hypothetical-protein
MVRAKRTVVAYASANGSTKEIADRVADGLRAAGATVHLCDLTAAGPPDHTAIGADHLVIGSAIHNGQWLSAAERFAEMVANERDGPVWAFSVSSVGETSTFLSPRVARFLRPRTPLPRAVAAIEASGTLRDHRKFAGAIAKGDWPGVGRIVFRLMGGHYGDARDWGDVDHWCRQIVDDNR
>NZ_CP046257.1|WP_035753399.1|1140222_1140777_-|hypothetical-protein
MHEMSTPQPLPWPQALSAFGRCLVDVVRSLRQRRLHQPSANLGRVIAFADGTQATVYRETVHDNGPVTEPVSLIVAFQLRGVGGNRVAHRLFRLESACNTVLFAGFDGFVSKLWMTADHKHMYRGVYEWDGYDSAVDYVRALWWPLMVVSRRDSIRFHVVGESTRASLLDGAHGDSDGSWWQPV
>NZ_CP046257.1|WP_155225049.1|1140918_1143231_+|phosphoenolpyruvate-synthase
MRHVLTFAELGLEQMMVVGGKAANLGELVTAGLPVPDGFALTADAFAESMRDGGVHEDLVATHREALSAVGDDARLADLSRRMAEMVTKVGITPRIVDEVLAAYRSLDSDAGPNGSGGNGSGANVAVRSSAVGEDGKDASFAGMNASFTNVGSADELLGAIVRCWASLFSPRVVSYRAEKGLSSDPLMAVVVQKMVSSEVAGIVFTADPVTGDLDHLVVEAVEGLGEAVVSGAVTPDTFLVARADCSVLETSMGNQEFRIVRGSDGHDRREPVAPGRTTPVIDPTTVQTIARMALRAERHYARPQDMEWAIDPQHRIWIVQSRPITTGVDTSDESSKPVLLRGLAAAPGIASGEVRILHSPRDGHQLIDGEVLVAPMTDPDWLPTIRRASAVVTDRGGITCHAAIVAREVGVPCIVGTRTGTKVLTAGSVVTVDGGSGEVRSGRVAPQRATVTEVSASSGAQGQPAVVTATKIYVNLGSPEHAAEVGATGVDGVGLLRAEFMLTEALSGRHPRAVIAAGETEAAISAMADALGRIAGPFGTRPVVYRTTDLRTNEFRGLEGGQEFEPEERNPMIGFRGCYRYVSEPEVFRLELAALARARETHPNLHVMLPFVRTRWELERCLELIDESPLGRQRGLHRWVMAEVPSVMYWLPEYVEAGIDGVSIGSNDLTQLILGVDRDSESCAELFDGSDPAVLDAIATIISTARRCGITSSLCGQAPSTNPDFAERLVRMGITSVSVNPDAIATTRLHVARAEQRLLVEAVLDAPGR

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Crispr_ID: NZ_CP046257_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046257_3

1693037-1693129

Orphan

Consensus_repeat	Method
TTCCGCGCCGGGAGCGTAGCGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046257_3

>merge|NZ_CP046257|3|1693037-1693129|CRISPRCasFinder
TTCCGCGCCGGGAGCGTAGCGAGCGGGCGGGGTGTGTCCGCGCCGGGAGCGTAGCGAGCGGGCGGGGTGTGTCCGCGCCGGGAGCGTAGCGAG

>NZ_CP046257|3|3|1693037-1693129|CRISPRCasFinder
TTCCGCGCCGGGAGCGTAGCGAG	CGGGCGGGGTGTGTCCGCGCCGGGAGCGTAGCGAGCGGGCGGGGTGT
GTCCGCGCCGGGAGCGTAGCGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046257.1\|WP_006357728.1\|1699719_1701132_-\|class-II-fumarate-hydratase	unknown	unknown	gnl\|CDD\|234779
NZ_CP046257.1\|WP_006357719.1\|1687895_1689116_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046257.1\|WP_006357717.1\|1686234_1686807_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP046257.1\|WP_006357718.1\|1686827_1687769_-\|type-I-pantothenate-kinase	unknown	unknown	gnl\|CDD\|235466
NZ_CP046257.1\|WP_006357713.1\|1682029_1683532_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP046257.1\|WP_035750516.1\|1694629_1694836_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046257.1\|WP_006357724.1\|1696040_1696688_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP046257.1\|WP_006357714.1\|1683629_1684424_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|187579
NZ_CP046257.1\|WP_035750513.1\|1693686_1694643_+\|transpeptidase	unknown	unknown	gnl\|CDD\|226309
NZ_CP046257.1\|WP_006357720.1\|1690525_1691398_+\|fatty-acid-desaturase	unknown	unknown	gnl\|CDD\|153109
NZ_CP046257.1\|WP_006357727.1\|1699022_1699706_-\|GlcNAc-PI-de-N-acetylase	unknown	unknown	gnl\|CDD\|225031
NZ_CP046257.1\|WP_006357730.1\|1702955_1703951_-\|class-II-fructose-bisphosphatase	unknown	unknown	gnl\|CDD\|236536
NZ_CP046257.1\|WP_005195760.1\|1689179_1690457_+\|serine-hydroxymethyltransferase	unknown	unknown	gnl\|CDD\|234571
NZ_CP046257.1\|WP_035750519.1\|1694981_1695857_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP046257.1\|WP_127963435.1\|1698690_1698870_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046257.1\|WP_081474316.1\|1684450_1684909_+\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NZ_CP046257.1\|WP_006357725.1\|1696934_1698662_+\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|226951
NZ_CP046257.1\|WP_006357712.1\|1681288_1682071_+\|isoprenyl-transferase	unknown	unknown	gnl\|CDD\|237825
NZ_CP046257.1\|WP_006357729.1\|1701139_1702837_-\|fumarate-hydratase	unknown	unknown	gnl\|CDD\|237955
NZ_CP046257.1\|WP_006357716.1\|1684999_1686163_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173848

Protein	Function_ID	Function_description	E-value
NZ_CP046257.1\|WP_006357728.1\|1699719_1701132_-\|class-II-fumarate-hydratase	gnl\|CDD\|234779	PRK00485, fumC, fumarate hydratase; Reviewed.	0
NZ_CP046257.1\|WP_006357717.1\|1686234_1686807_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.1305e-08
NZ_CP046257.1\|WP_006357718.1\|1686827_1687769_-\|type-I-pantothenate-kinase	gnl\|CDD\|235466	PRK05439, PRK05439, pantothenate kinase; Provisional.	0
NZ_CP046257.1\|WP_006357713.1\|1682029_1683532_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	6.10901e-105
NZ_CP046257.1\|WP_006357724.1\|1696040_1696688_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	5.55991e-59
NZ_CP046257.1\|WP_006357714.1\|1683629_1684424_+\|hypothetical-protein	gnl\|CDD\|187579	cd05271, NDUFA9_like_SDR_a, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs. This subgroup of extended SDR-like proteins are atypical SDRs. They have a glycine-rich NAD(P)-binding motif similar to the typical SDRs, GXXGXXG, and have the YXXXK active site motif (though not the other residues of the SDR tetrad). Members identified include NDUFA9 (mitochondrial) and putative nucleoside-diphosphate-sugar epimerase. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.21095e-13
NZ_CP046257.1\|WP_035750513.1\|1693686_1694643_+\|transpeptidase	gnl\|CDD\|226309	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown].	3.09784e-31
NZ_CP046257.1\|WP_006357720.1\|1690525_1691398_+\|fatty-acid-desaturase	gnl\|CDD\|153109	cd01050, Acyl_ACP_Desat, Acyl ACP desaturase, ferritin-like diiron-binding domain. Acyl-Acyl Carrier Protein Desaturase (Acyl_ACP_Desat) is a mu-oxo-bridged diiron-carboxylate enzyme, which belongs to a broad superfamily of ferritin-like proteins and catalyzes the NADPH and O2-dependent formation of a cis-double bond in acyl-ACPs. Acyl-ACP desaturases are found in higher plants and a few bacterial species (Mycobacterium tuberculosis, M. leprae, M. avium and Streptomyces avermitilis, S. coelicolor). In plants, Acyl-ACP desaturase is a plastid-localized, covalently ACP linked, soluble desaturase that introduces the first double bound into saturated fatty acids, resulting in the corresponding monounsaturated fatty acid. Members of this class of soluble desaturases are specific for a particular substrate chain length and introduce the double bond between specific carbon atoms. For example, delta 9 stearoyl-ACP is specific for stearic acid and introduces a double bond between carbon 9 and 10 to yield oleic acid in the ACP-bound form. The enzymatic reaction requires molecular oxygen, NAD(P)H, NAD(P)H ferredoxin oxido-reductase and ferredoxin. The enzyme is active in the homodimeric form; the monomer consists mainly of alpha-helices with the catalytic diiron center buried within a four-helix bundle. Integral membrane fatty acid desaturases that introduce double bonds into fatty acid chains, acyl-CoA desaturases of animals, yeasts, and fungi, and acyl-lipid desaturases of cyanobacteria and higher plants, are distinct from soluble acyl-ACP desaturases, lack diiron centers, and are not included in this CD.	7.16771e-40
NZ_CP046257.1\|WP_006357727.1\|1699022_1699706_-\|GlcNAc-PI-de-N-acetylase	gnl\|CDD\|225031	COG2120, COG2120, Uncharacterized proteins, LmbE homologs [Function unknown].	3.25648e-23
NZ_CP046257.1\|WP_006357730.1\|1702955_1703951_-\|class-II-fructose-bisphosphatase	gnl\|CDD\|236536	PRK09479, glpX, fructose 1,6-bisphosphatase II; Reviewed.	0
NZ_CP046257.1\|WP_005195760.1\|1689179_1690457_+\|serine-hydroxymethyltransferase	gnl\|CDD\|234571	PRK00011, glyA, serine hydroxymethyltransferase; Reviewed.	0
NZ_CP046257.1\|WP_035750519.1\|1694981_1695857_-\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	6.37852e-20
NZ_CP046257.1\|WP_081474316.1\|1684450_1684909_+\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	4.15614e-20
NZ_CP046257.1\|WP_006357725.1\|1696934_1698662_+\|GAF-domain-containing-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.93682e-34
NZ_CP046257.1\|WP_006357712.1\|1681288_1682071_+\|isoprenyl-transferase	gnl\|CDD\|237825	PRK14828, PRK14828, undecaprenyl pyrophosphate synthase; Provisional.	1.86211e-131
NZ_CP046257.1\|WP_006357729.1\|1701139_1702837_-\|fumarate-hydratase	gnl\|CDD\|237955	PRK15389, PRK15389, fumarate hydratase; Provisional.	0
NZ_CP046257.1\|WP_006357716.1\|1684999_1686163_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173848	cd01159, NcnH, Naphthocyclinone hydroxylase. Naphthocyclinone is an aromatic polyketide and an antibiotic, which is active against Gram-positive bacteria. Polyketides are secondary metabolites, which have important biological functions such as antitumor, immunosupressive or antibiotic activities. NcnH is a hydroxylase involved in the biosynthesis of naphthocyclinone and possibly other polyketides.	1.38183e-85

>NZ_CP046257.1|WP_006357720.1|1690525_1691398_+|fatty-acid-desaturase
MNALTEDDLIIALEKALPEIAEDHQSAATPWNPHDWVPWDEGRNFAFLGGDDYDPSQATLSDEARAGLLALLLTKDNLPSYHRVLAKHFPAFSEWRQLIGVWTAEDNRHSIVLRDYLVVRRAIDPVDAENRRLVHVTKGYRQTPEQVDPLGPLDVLALMAVHENQCVSFIKRLSAIAADDVLEQILTKIAADDQQQANTFGAFLNAGIIADQDATVIAIDSALALGRAEAIGHDIDDFDAERALLADYENEDTWREIAATLADAVKLDSIEGLGDEAEAARQRILSRARG
>NZ_CP046257.1|WP_005195760.1|1689179_1690457_+|serine-hydroxymethyltransferase
MSLAELDPDVAAAMNGELSRQRDTLEMIASENFVPRAVLQAQGSVLTNKYAEGYPGRRYYGGCEYVDVVEDIARNRAKELFGADFANVQPHSGAQANAAVLQALMEPGETMLGLDLAHGGHLTHGMRLNFSGKLYENAFYGVSKEDFRIDMDEVRKIALDVKPKVIVAGWSAYPRTLDFEAFRSIADEVGAHLWVDMAHFAGLVAAGLHPSPVPHADVVSSTVHKTLGGPRSGIILAKQEWAKKLNSAVFPGQQGGPLMHAIAGKAVALKIAGTEEFAERQRRTLSGASILAERLNGEDVAKAGVSVLTGGTDVHLVLVDLRNSDLDGQQAEDLLHQVGITVNRNAVPFDPRPPMVTSGLRIGTPALATRGFGDEEFTEVADIIATALAAGSSADVSALRGRVSKLALDFPLYEGLEEWGLMSRI
>NZ_CP046257.1|WP_006357719.1|1687895_1689116_+|hypothetical-protein
MPADHATPDLVTDYLRLGLAFDRLEEGFVDAFTGDPALRAEIANGPAPDPAHLAAQARALRADLPGDLPADRAEFIGSHLRALECSARKFAGDDISFVDEVNAYFDVDIALADPDRYRQAHTELADALGIADASGEDLRDAYAAHRRADEIPADKVDECVRAFSGALRERVRAQYPLPDNEIVDFEVVTDKPWSGFNYYLGDYWSRVAINADLTQYMSSLPHLIAHEAYPGHHTEHCRKEQLLVGAGQHEQSIFLVNTPQCLMAEGLADHALTAIMGKEWGGWAQEIYADLGLRFDADRATRVGRATSGLLTVRQDAALMLHDQHADADTVADFLQTWLLAPPERARQMLRFLTSPLWRAYISTYVEGYRLLESWLDAADDRAAAFGRLLDEPLIPASLRRELVAG
>NZ_CP046257.1|WP_006357718.1|1686827_1687769_-|type-I-pantothenate-kinase
MARNASDRDPSLYLELDRRQWRELRESMPLVLNEDELAELVGLGEQIDLEEVADVYLPLSRLIHLQVAARQRLFAATSTFLGERQVNRQVPFVIGIAGSVAVGKSTTARVLAALLARWESHPKVDLITTDGFLLPTAEMQRRGILHRKGFPESYDRRALLRFVTEVKSGAREVAAPVYSHLAYDIVPSVYHYVRQPDILILEGLNVLQTGPTLMVSDLFDFSIYVDAKIEDIEEWYISRFLQMRTTSFANPDSHFHAYASLTDEQATAAARDLWTSINRPNLIENILPTRPRASLVLRKDVDHAINRVRLRKL
>NZ_CP046257.1|WP_006357717.1|1686234_1686807_+|TetR/AcrR-family-transcriptional-regulator
MGRAQEGGGGHLSADDWIELGYAILAEDGFKQIKIDTVCKRMGVTKGSFYWHFKDIAAYRSALVARWGEWNDEEHQNFAALADLPPRDRLLGLIAQLTSPRHWMIERAMREWARSDPNAEASIRTSDRRAREAVRRCLLDHGMDPKTASVRSNWIFAMGIGALHLSYSEEDRASAGRHSAELVDLMLTPT
>NZ_CP046257.1|WP_006357716.1|1684999_1686163_-|acyl-CoA-dehydrogenase
MDTPTSGTVLITDEFIASLAERAGRAEELRQLPAETIRDATDSGLLDLLIPSRFGGLEAPFPEILDHVRRLAHGCTSSAWTLGFYTLHGWITALFSEAAQEEAFADRPYLAPAPLAPTGTAEPRDGGFSVSGRWSWATGIMEANWVMVGAIVTGDRPDAVLALLPIDDARVEDVWHTDGMRATGSNDVVVENAFVPAHRTVRVRDLYAGRTPGATLHDNYSYRWPMVPALALLAAMPALGTAERVADLYAARLSERVLAYQMVKQKDKPAARIRLGDARIRLQALRGLLAQTTATIDEILAAGGTVDIRTRAQARLAAARIVNESRAVIGTLLEASGASVHFLDHPMQRARRDVDVLSGHVVFDYDEIREIAASLEIGMEISPFAMV
>NZ_CP046257.1|WP_081474316.1|1684450_1684909_+|carboxymuconolactone-decarboxylase-family-protein
MWIPQDNPAVYKALVALQRASSAGVDVEIGELISMRVSQLNGCAYCLHMHAGDALAAQIDPHKLLMLATWREAGSLFSSRERAVLALAEQLTRLGEGGVDDAVFDDVRTCFDAATTGQLVAAIVMINAWNRIAVAGGYPAGLDERRVSQAAG
>NZ_CP046257.1|WP_006357714.1|1683629_1684424_+|hypothetical-protein
MKIVVIGASGVLGSRVADLLAERGNEVVRANRGAGVDAYTGEGLARAMSGADVVVDCLSVETLSAKKAVDFFRTTARNIGRAATAAAVGHVVCVSIVNADDPTVNAKFGYYQGKAAQEAAYRDVVDPATLTILASVQWFELAEQMMGRMAVGPVAIVPKMRCRPAAAEDVAKVVADTATAGPVTADAGGVRKIEVAGPAEMNLVDVAKAVAAQRGSPRWIIGAAVGGSAIRGGGLVPANPDVITPTTLEQWLAQRSGAHAGSAR
>NZ_CP046257.1|WP_006357713.1|1682029_1683532_-|PLP-dependent-aminotransferase-family-protein
MEENRVNPSATATDPWAEVAARLGADLFLDLQPDPGASARGRGATLRRTLTEALRSAILDGRLPAGTALPPYRSLAADLGLARGTVSAVYQELIAEGWLTARQGSATRVADGAAHPETASNRKADERPSTPSPFRFPHDFSLGQPCAGMFPRTDWIRATRRVLTGAGDEVFAPTHPQGRAELRRALSGYLSRTRGVRTTADLIVLGTAVQSALELLSRTVFGDVLAVEGHGLPFHWQAVVRGGTRVVPIAVDDEGMVIDDLERSGAAAVLLSPSHQFPTGVPLSPARRMQVIEWARRTGAVIVEDDYDGEFRYDRDPVGALQALGPDVVIHAGSMSKSLSPAVRAGWLALPPHLMDVVMNAKGVREGDASIVDQLILADLIDSGAYDRHIRRSRQVYRQRRDALVEAVTACGLGLPGIAAGLHAVIPVDHADEGALVHEAFRRGIGLVGLSLFRHPDADPLPHGGLVVGFGTPAASTFTADLQALRDLLAESPAARRVVP
>NZ_CP046257.1|WP_006357712.1|1681288_1682071_+|isoprenyl-transferase
MKLLPDRVRRPALTIYERRLIQLLDTQRLPRHVAIICDGNRRWAREAGFDDVSHGHRVGAQRIADMLGWCAGLGIEAVTIYLLSTENLNRSSDELDALLEIVPDIVDEISSPDGDWCIRIVGTLDALPEAVAGRLRVAAERTSERDGMNVNVAVGYGGRQEIVDAVRALLDEKRAAGATAEEMIEAVTVEAIDANLYTKGQPDPDLVIRTSGEQRLSGFLLWQSAYSEIWFTDAYWPEFRRVDFLRALRDYSARSRRFGK
>NZ_CP046257.1|WP_035750513.1|1693686_1694643_+|transpeptidase
MRLLGLLVIAVLAACAGGAGQALADPETTTPITPPTTPGSPSLPGMGEGLGIPLLDEVLNQLSGDNGSADAPGGVGGAGGPTGQMIVVTAPKASDTTATLTAFEKGNDGSWKPVPGLGPTKAFLGSLGMGEPQDNVPRTPEGTFPLDQAFGRQENPGTKMPYLKVDTQDWWDSDPKSPTYNTHVRQPQSPGGDSENLYNSGPVYDYAVNIAHNPQRTPGKATAMFLHVTNDQPTLGCVAIERELMKKILVWLDPAKSPKITIGVNQGAPTGEAPGATPQTTPGATPSTPDVPAADMLTGLLSQLVGAVPALFGQFTGR
>NZ_CP046257.1|WP_035750516.1|1694629_1694836_-|hypothetical-protein
MTVISPLFAETEGSADRNCDSCGRSFVLRRPLAEPDRDQWARVNGWHIGVEETFCPACRHARSEISDP
>NZ_CP046257.1|WP_035750519.1|1694981_1695857_-|universal-stress-protein
MTASRFTDGPVVVGVDGSATARAAARWAARDAALHRSEIEMIASANLSADDPYVLEPLRARCERALAEARRVAEDSSDSTDPLKITTQVVDSPPVTALLEASDRARLLVVGNRGHMAGHRVALGTITTALAEHCRCPLTVVRDSTSNWSQASIAVGTDGSPGGRVAVDAAFAAADLRGVPVTVVHAWCDTDVADMSVPCTMSEWPSRRSRADAWLDAELDEVRRRYPQVTVRCAVTRDRPARALLDHAQAAQLLVVGARGRGGFAAMRLGSTSLSVLRSARGPVMVVPRDR
>NZ_CP046257.1|WP_006357724.1|1696040_1696688_-|response-regulator-transcription-factor
MFSVFLVDDHEIVRRGLVELLDHDDNVRVVGEAATCAQALARIPTVQPDVAVLDVRLPDGNGIELCRDLLSRVDGLRCLILTSMTDDEAMMDAILAGASGYVIKDITGMELARAITDVGAGRSLLDNRAAAALMDRLRTQREKEEKPGDGLSEQESTLLALLGEGLTNRQIAARMHLAEKTVKNYVSRLLGKLGMERRTQAAVYATKAARRGHAH
>NZ_CP046257.1|WP_006357725.1|1696934_1698662_+|GAF-domain-containing-protein
MVRESRERGVGSFEVQNELSQMRLRELLDEVRDRITQIADVRDRIDGLLEAMLMVSSDLDLETTLEAIVSAGTRLVDAEYGAVGVLGSGHDLSAFLAQGIGEDVRAEIGHLPTGRGVLGQLIDDPRVLRLTDLSEHPASVGFPPNHPPMTSFLGAPIRVRDEIFGNLYLTEKKNGALFTEDDELVIQALASAAGIAIENARLYEQAQTQLAWIEANRDVIAELLTGADQQDVLESIARKVLTLADADLVCIAEPHDHEMPAESVEELVVTVAEGVDAEVFRGRTVPIKGSTSGDAFVRRRPVLREELEYDISGDSSTQHGPVMVAPLRTAESTRGVLIAVRSKGRDGFAEDLLSLSANFADQGALALQLASATNQAHEMRVLEDRERIARDLHDHVIQRIFAEGLTLQATLQRTQSSEIRARLTRSINNLQDIVQDVRSTIFDLQAEETETTRLRQRVQETIDQQIDDLPIQTHVRMAGPLSIVEPRLADQVVAVVREALSNAVRYAHATTVTVAISVGDELAVEVTDDGVGLPEDVTPSGLKNLRHRAKQLGGAFALNTPDSGRGLSVRWAVPL
>NZ_CP046257.1|WP_127963435.1|1698690_1698870_-|hypothetical-protein
MTLTGVLVVFLAAFAVCALVGLSIWLIVLFGLLSGVQAVAWVTERTSAWRLPAEPGTGP
>NZ_CP046257.1|WP_006357727.1|1699022_1699706_-|GlcNAc-PI-de-N-acetylase
MTSPEPFPTDWQTALVLVAHPDDPEYGMAAAVARWTGEGKRVVYALASSGERGIEGMTPAECGPLREAEQRASAKIVGVDEVEFWGFPDSDIRNTPELRAKITETVERIAPQVILSLYGGPEWAPGQPNQRDHMEFAAAVLDAYDALTAHSGEVPAWLFENGPAATHAVDVDAQFEVAVRSLAAHDRYLSVLDPDTPVLDQARAQIDRATAPRDDVRVAGFELKRTR
>NZ_CP046257.1|WP_006357728.1|1699719_1701132_-|class-II-fumarate-hydratase
MTQAQGKQEFRTEHDTMGEVQVPIDALWRAQTQRAVENFPISHRPLERTQIRAMGLLKAACATVNSDLGLLDAERADAIIAAATEIADGKHDDQFPIDVFQTGSGTSSNMNTNEVIASIAKANGVDVHPNDHVNMSQSSNDTFPTATHVAATEAVVTDLVPALEHLRKSLADKATEWRDVVKSGRTHLMDAVPVTLGQEFAGYARQVEAGIERVTATLPRVGELPIGGTAVGTGLNAPAGFGTKVVAELVRRTGVEELSLAKDNFEAQAARDGLVELSGQLKTIAVSLTKIANDVRWMGSGPLTGLGEILLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVVGNDAAVTWGGGNGAFELNVYIPMMARNVLESLKLLANVSRLFADRCISGLEANVDRLRTLAESSPSIVTPLNSAIGYEEAAAVAKQALKEGKTIRQTVIDRGLVGDKLSEEELDARLDVLKMANLDRER
>NZ_CP046257.1|WP_006357729.1|1701139_1702837_-|fumarate-hydratase
MSKPASAPEFLYSDLLPVGADETPYRLITTEGVSTFEAGGQTFLKVEPEAIRKLTAEAMHDISHYLRPAHLAQLRRIIDDPDASGNDRFVALDLLKNVNISAGGVLPMCQDTGTAIVMGKKSEGVLTGTDDAEAISKGVYDAYTQLNLRYSQLAPLTTYEEKNTGTNLPAQVEIYATEQGPKGPEYKFLFMAKGGGSANKSFLFQETKAILNPKSILKFLDEKIRSLGTAACPPYHLAVVIGGTSAEFALKTAKYASAHYLDNLPTQGSMSAHGFRDLELEDEVFTLTQSFGIGAQFGGKYFCHDVRVVRLPRHGASCPVAIAVSCSADRQALGKITADGVFLEQLETDPAKYMPAAGVAEDISGGEVVEVDLNRPMSEILAQLSQYPVKTRLSLTGPLVVARDIAHAKIKERLDAGEPMPDYLRDHPVYYAGPAKTPEGMASGSFGPTTAGRMDSYVEQFQAAGGSMVMLAKGNRSKQVTEACNSHGGFYLGSIGGPAARLALDCIKSQEIIEYPELGMEAVWKIEVENFPAFIVVDDKGNDFFTDPSGSVNVPLSGIRIRSKE
>NZ_CP046257.1|WP_006357730.1|1702955_1703951_-|class-II-fructose-bisphosphatase
MTASSHQAPDRNLAMELVRVTESAALAAGRWVGRGDKNGGDGAAVDAMRQLLSTVSMRGVVVIGEGEKDEAPMLYNGEEVGNGEGPDCDVAVDPIDGTTLMAEGRPNSISVIAVSERGTMYDPSAVFYMDKIAVGPDAKGAININESVEWNINSVAKAKGIDVADLTVIVLDRPRHADLIGEIRQAGAKIRLISDGDVAGAVAAADDYSTVDMLMGVGGTPEGIITAVAMKCMGGEIQGKLWPRNDEERQKAIDAGHDLDRVLTNDILVSGENSFFCATGVTNGDMLRGVTYRPNGATTRSLVMRSKSGTVRRIEAVHKPAKLREYARINL

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Crispr_ID: NZ_CP046257_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046257_4

2077010-2077130

Orphan

Consensus_repeat	Method
GAGCAGGACCACTGACGCCGGAGGCGTTGAGCAGACCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046257_4

>merge|NZ_CP046257|4|2077010-2077130|CRISPRCasFinder
GAGCAGGACCACTGACGCCGGAGGCGTTGAGCAGACCACTGACGCCGGAGGCGTTGAAGGAGACCACTGACGCCGGAGGCGTTGAGCAGACCACTGACGCCGGAGGCGTTGAGCAGACCAC

>NZ_CP046257|4|4|2077010-2077130|CRISPRCasFinder
GAGCAGGACCACTGACGCCGGAGGCGTTGAGCAGACCAC	TGACGCCGGAGGCGTTGAAGGAGACCACTGACGCCGGAGGCGT
TGAGCAGACCACTGACGCCGGAGGCGTTGAGCAGACCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046257.1\|WP_035755324.1\|2077169_2078048_+\|acyl-CoA-thioesterase-II	unknown	unknown	gnl\|CDD\|224857
NZ_CP046257.1\|WP_035755318.1\|2065099_2066431_+\|tryptophan-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|235288
NZ_CP046257.1\|WP_035755315.1\|2064219_2065038_+\|indole-3-glycerol-phosphate-synthase-TrpC	unknown	unknown	gnl\|CDD\|234710
NZ_CP046257.1\|WP_035755313.1\|2061663_2063256_+\|anthranilate-synthase-component-I	unknown	unknown	gnl\|CDD\|184152
NZ_CP046257.1\|WP_006359160.1\|2063252_2064038_+\|Trp-biosynthesis-associated-membrane-protein	unknown	unknown	gnl\|CDD\|378200
NZ_CP046257.1\|WP_006360585.1\|2082652_2083090_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377730
NZ_CP046257.1\|WP_155225211.1\|2069345_2073917_+\|glutamate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|236968
NZ_CP046257.1\|WP_042376157.1\|2084257_2085667_-\|ethanolamine-ammonia-lyase-subunit-EutB	unknown	unknown	gnl\|CDD\|237897
NZ_CP046257.1\|WP_006360586.1\|2083103_2083439_+\|SHOCT-domain-containing-protein	unknown	unknown	gnl\|CDD\|378276
NZ_CP046257.1\|WP_005196147.1\|2085900_2086692_+\|dihydroxynaphthoic-acid-synthetase	unknown	unknown	gnl\|CDD\|180958
NZ_CP046257.1\|WP_035755320.1\|2067340_2069008_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|237284
NZ_CP046257.1\|WP_006360587.1\|2083460_2084261_-\|ethanolamine-ammonia-lyase-subunit-EutC	unknown	unknown	gnl\|CDD\|235482
NZ_CP046257.1\|WP_042376160.1\|2066427_2067237_+\|tryptophan-synthase-subunit-alpha	unknown	unknown	gnl\|CDD\|237285
NZ_CP046257.1\|WP_005196179.1\|2061487_2061667_+\|4-oxalocrotonate-tautomerase	unknown	unknown	gnl\|CDD\|224853
NZ_CP046257.1\|WP_155225212.1\|2078724_2080707_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|226646
NZ_CP046257.1\|WP_006360579.1\|2073909_2075415_+\|glutamate-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|237213
NZ_CP046257.1\|WP_006360589.1\|2086724_2087474_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|132250
NZ_CP046257.1\|WP_006359158.1\|2061076_2061448_+\|phosphoribosyl-AMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234598
NZ_CP046257.1\|WP_006360584.1\|2080817_2082656_+\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|223953
NZ_CP046257.1\|WP_035755326.1\|2078058_2078523_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP046257.1\|WP_035755324.1\|2077169_2078048_+\|acyl-CoA-thioesterase-II	gnl\|CDD\|224857	COG1946, TesB, Acyl-CoA thioesterase [Lipid metabolism].	3.80792e-106
NZ_CP046257.1\|WP_035755318.1\|2065099_2066431_+\|tryptophan-synthase-subunit-beta	gnl\|CDD\|235288	PRK04346, PRK04346, tryptophan synthase subunit beta; Validated.	0
NZ_CP046257.1\|WP_035755315.1\|2064219_2065038_+\|indole-3-glycerol-phosphate-synthase-TrpC	gnl\|CDD\|234710	PRK00278, trpC, indole-3-glycerol phosphate synthase TrpC.	1.36332e-132
NZ_CP046257.1\|WP_035755313.1\|2061663_2063256_+\|anthranilate-synthase-component-I	gnl\|CDD\|184152	PRK13571, PRK13571, anthranilate synthase component I; Provisional.	0
NZ_CP046257.1\|WP_006359160.1\|2063252_2064038_+\|Trp-biosynthesis-associated-membrane-protein	gnl\|CDD\|378200	pfam09534, Trp_oprn_chp, Tryptophan-associated transmembrane protein (Trp_oprn_chp). Members of this family are predicted transmembrane proteins with four membrane-spanning helices. Members are found in the Actinobacteria (Mycobacterium, Corynebacterium, Streptomyces), always associated with genes for tryptophan biosynthesis.	2.38751e-32
NZ_CP046257.1\|WP_155225211.1\|2069345_2073917_+\|glutamate-synthase-large-subunit	gnl\|CDD\|236968	PRK11750, gltB, glutamate synthase subunit alpha; Provisional.	0
NZ_CP046257.1\|WP_042376157.1\|2084257_2085667_-\|ethanolamine-ammonia-lyase-subunit-EutB	gnl\|CDD\|237897	PRK15067, PRK15067, ethanolamine ammonia-lyase subunit EutB.	0
NZ_CP046257.1\|WP_006360586.1\|2083103_2083439_+\|SHOCT-domain-containing-protein	gnl\|CDD\|378276	pfam09851, SHOCT, Short C-terminal domain.	1.03904e-09
NZ_CP046257.1\|WP_005196147.1\|2085900_2086692_+\|dihydroxynaphthoic-acid-synthetase	gnl\|CDD\|180958	PRK07396, PRK07396, dihydroxynaphthoic acid synthetase; Validated.	4.76691e-131
NZ_CP046257.1\|WP_035755320.1\|2067340_2069008_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|237284	PRK13108, PRK13108, prolipoprotein diacylglyceryl transferase; Reviewed.	3.31826e-152
NZ_CP046257.1\|WP_006360587.1\|2083460_2084261_-\|ethanolamine-ammonia-lyase-subunit-EutC	gnl\|CDD\|235482	PRK05465, PRK05465, ethanolamine ammonia-lyase subunit EutC.	9.3915e-115
NZ_CP046257.1\|WP_042376160.1\|2066427_2067237_+\|tryptophan-synthase-subunit-alpha	gnl\|CDD\|237285	PRK13111, trpA, tryptophan synthase subunit alpha; Provisional.	5.68603e-118
NZ_CP046257.1\|WP_005196179.1\|2061487_2061667_+\|4-oxalocrotonate-tautomerase	gnl\|CDD\|224853	COG1942, COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only].	8.13454e-13
NZ_CP046257.1\|WP_155225212.1\|2078724_2080707_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|226646	COG4178, COG4178, ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only].	0
NZ_CP046257.1\|WP_006360579.1\|2073909_2075415_+\|glutamate-synthase-subunit-beta	gnl\|CDD\|237213	PRK12810, gltD, glutamate synthase subunit beta; Reviewed.	0
NZ_CP046257.1\|WP_006360589.1\|2086724_2087474_+\|SDR-family-oxidoreductase	gnl\|CDD\|132250	TIGR03206, benzo_BadH, 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase. Members of this protein family are the enzyme 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase. The enzymatic properties were confirmed experimentally in Rhodopseudomonas palustris; the enzyme is homotetrameric, and not sensitive to oxygen. This enzyme is part of proposed pathway for degradation of benzoyl-CoA to 3-hydroxypimeloyl-CoA that differs from the analogous in Thauera aromatica. It also may occur in degradation of the non-aromatic compound cyclohexane-1-carboxylate.	9.06982e-77
NZ_CP046257.1\|WP_006359158.1\|2061076_2061448_+\|phosphoribosyl-AMP-cyclohydrolase	gnl\|CDD\|234598	PRK00051, hisI, phosphoribosyl-AMP cyclohydrolase; Reviewed.	3.90312e-67
NZ_CP046257.1\|WP_006360584.1\|2080817_2082656_+\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|223953	COG1022, FAA1, Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism].	0
NZ_CP046257.1\|WP_006360585.1\|2082652_2083090_+\|hypothetical-protein	gnl\|CDD\|377730	pfam06897, DUF1269, Protein of unknown function (DUF1269). This family consists of several bacterial and archaeal proteins of around 200 residues in length. The function of this family is unknown. The family carries a repeated glycine-zipper sequence- motif, GxxxGxxxG, where the x following the G is frequently found to be an alanine. As glycine-zippers occur in membrane proteins, this family is likely to be found spanning a membrane.	0.00673114

>NZ_CP046257.1|WP_006360579.1|2073909_2075415_+|glutamate-synthase-subunit-beta
MADPRGFLEVPKKEAKYRPVAERVQDWDDVYVHADDPTKVLAEVSTQARRCMDCGIPFCHSGTAGCPLGNLIPEWNDLVRRGRWDAASSRLHATNNFPEFTGMVCPAPCEAACVLSISERETGGSVTIKRIEKTIAYESWAEGVIGPEPPESKTGKSVGVVGSGPAGLAAAQQLTRAGHDVTVYERDDRLGGLLRYGIPEYKLQKSDIDRRIAQMRAEGTEFVTSCDVGTDLTVEDLRARHDAVVLAIGAMEARDNPVPGRELNGVHLAMEHLVPANRECEGDGPSPITAAGKHVVIIGGGDTGADCLGTAHRQGAASVVQLDYNPELPDERDDSRSPWPTWPLVMRTSSAHAEGGERKYQVAVQRFLGDVEGNVTTMVLAEVEVQRDADGRREIRPVGDEFEIPCELALFAIGFAGVERGELLSGLEIEPNKRGAISCGSDWQTDAPGIFVCGDAHRGASLVVWAIAEGRSTARAVDEFLVGESDLPSPVRPAALPLSVR
>NZ_CP046257.1|WP_155225211.1|2069345_2073917_+|glutamate-synthase-large-subunit
MLFSALPAKQGLYDPEAEVDSCGVAMVTDIHGRRSHSIVADGLLALENLEHRGAAGAETNSGDGAGILIQLPDELLRATVDFELPEPAADGSHTYAAGTCFLPMDEELRRQAIARVEALAADEGITILGWRDVPVDHEHADIGGTAVACMPYMMQLFVTVDPEPGAERIGGVAVDRFIYPFRKQAERVTPEIEEAGTGLYFPSLSSRTMVYKGMLTTMQLPLYYADLRDDRCQSAIAIVHSRFSTNTFPSWPLAHPFRFVAHNGEINTVRGNRNRMRAREALLDTDLIPGDLKRAFPICTPEASDSASLDEVLELLHLGGRSVPHAVMMMVPEAWENVPDMDPKRRAFLQFNASLMEAWDGPACVTFTDGTVVGAVLDRNGLRPGRWWQTRDGRIILASEAGVLDVPVDDIISKGRLEPGRMFLVDTTAGRIIPDEEIKGELMHAEAYDEWLHAGLLDIATLPERPVFQPNHDTVVRRQQSFGYSEEDLRVLLTPMAASGYEPLGSMGTDTPIAVLSRRSRLLYDYFVELFAQVTNPPLDAIREEIVTSMGRVMGPEQNLLDPTAASCRQIMLHWPVLDNADLAKLVHINDDGDHPGLSAKVLRALYEVDDGGEGLRVALEDLRRRASQAIAEGHTTLVISDRLTDKDHAPIPSLLAISAVHHHLVRTKERTRVALVVESGDAREVHHIATLIGFGAAAVNPYLALETIEDLIAEGELTGVTPSKAIRNYLEALGKGVLKVMSKMGISTISSYTAAQAFEAVGLSSEVVREYFTRTVSRIEGVGLDELAEEVRIRHHRAFPENPTEQVYRRLEVGGEYQYRREGELHLFTPETIFLLQHATKSGRSEIFQKYSDEVDRLSRKGGTLRGLFEFDLDAREPIPIAEVEPVEEIMKRFNTGAMSYGSISAEAHETIAMAMNKIGGRSNSGEGGEDVDRLYDPERRSAVKQVASGRFGVTSDYLINATDIQIKMAQGAKPGEGGQLPAYKVYPWIAKTRHSTPGVALISPPPHHDIYSIEDLAQLIHDLKNANSQARIHVKLVSAVGVGTVATGVSKAHADVVLISGHDGGTGASPLTSLKHAGTPWEIGLADAQQTLMLNGLRDRITVQCDGALRTGRDVIMAALLGAEEYGFSTAPLIVAGCIMMRVCHLDTCPVGVATQNPQLRSRFTGQVDHLVNFFRFIAEDVRKYLAQLGYRTLDEAIGQSQRLHTDSAVAHWKSKGLDLLPIFRKVEGKGPSRRVREQYHALDRALDQTLIQLAEGALEDAHPVTLELPVRNVNRTVGTLLGAEVTRRFGAEGLAEDTIVVKLEGSAGQSLGAFLPPGVTIRLSGDTNDYVGKGLCGGKIVVAPHPDSWFVAEDQVIAGNTILYGATSGEVYLRGRVGERFSVRNSGATAVVEGVGDHACEYMTGGRVVILGPTGRNLAAGMSGGIAFVHDLDRDKVNMAMVKLMRPDPDDLAWLKDAITKHAELTGSAIGASILADWPRRCLAFTKVMPTDYKRVLDAARMAEAEGRDVDSAIMEAARG
>NZ_CP046257.1|WP_035755320.1|2067340_2069008_+|prolipoprotein-diacylglyceryl-transferase
MNAPTTTMLAYIPSPPQGVWDLGPFPLRAYALCIIAGIIVAVWWGNRRWVARGGQEGEVLDVAIWAVPFGLLGGRLYHLITDWKTYFGADAPKEPLDALRIWDGGLGIWGAVALGAVGAWIGARRRGIRLPAFGDAIAPPILLAQAIGRLGNYFNQELYGRETTLPWGLEIYERVNKAGYADAGLIDGKSNGVVVAVVQPTFLYELLWNVLIVVLLVVIDRKFRIGHGRLFALYIAGYCLGRFFIEMLRDDRAAVANDIAGIRPNLFTAALVFVCAIVYFVVAPKGREQGLEMYHPERAAELEEQGVAGYVDDWYDEDFDELDAAEGQEPPAEVDTLDALDAEADKVETTRVAAEPAAAAKVSDDEPAAEPVVDETAAGETETEEPVTEEAEAATGAVETEAVDSDAGESGAPESADAGVAEPEVAEPEVAEPEAEDDATTDVEATDTEAVDAATANAAEDDEADSVVENEDPASQVVESEDAATGVAESEAQATGVVESDPESSAVETDAPAAGDAESSAADSADVQATDAGQADASSSLRRRVASRFGRRRRP
>NZ_CP046257.1|WP_042376160.1|2066427_2067237_+|tryptophan-synthase-subunit-alpha
MSANTISSKTGPVFAKCREENRSALIGYLPVGYPTLEGSLTSFRTMVDAGCDIIEVGVPYSDPVMDGPTIQEAADLALTNEVRVRDVFTAVEAISSAGGTAVVMSYWNPVLQYGVENFARDLADAGGAGLITPNLIPEEGAQWHAASDQYGLDRIYLVAPSSTNERIALTVDASRGFVYAASTMGVTGARDAVSDMAPELCARVREYSDIPIGVGLGVRNREQAAQIASYSDGVIVGSALVTAAKAGQDRLASLVGELAEGVRSRHAAV
>NZ_CP046257.1|WP_035755318.1|2065099_2066431_+|tryptophan-synthase-subunit-beta
MTAHPDSAHPDSSATVLPPASTGLTTRTSIEPDEGGHFGVYGGRHVPEALMAVIDEVTTTFFKIRNDDAFLNELDRLQRDYAGRPSPLYEAKRLAEYAGGARIFLKREDLNHTGSHKINNVLGQALLAQRMGKNRIIAETGAGQHGVATATACALLGLECVIYMGRVDTDRQALNVARMRLLGAEVIAVDNGSATLKDAINEAMRDWVTNAHNTYYCFGTAAGPHPFPVMVRDLQRVVGLEARAQILDKAGRLPDAVTACVGGGSNAIGIFHPFIDDSDVRLVGFEAAGDGVETGRHAATFTGGTPGAFQGAYSYLLQDEDGQTTESHSISAGLDYPGVGPEHAYLKDTGRAEYRPITDTEAMNALALLSRREGIIPAIESAHAVAGALELGKELGEGAIIVVSLSGRGDKDVDTAARWFGLFDPPPSQDEAKATSGQPGERA
>NZ_CP046257.1|WP_035755315.1|2064219_2065038_+|indole-3-glycerol-phosphate-synthase-TrpC
MSMPNVLESIIEGVKADVAAREAMTDFAAVKAASAKAPAPRDAMVALRQPGIGVIAEVKRASPSKGELASIGDPAELAKAYEDGGARIISVLTEERRFHGSLADLDAVRAAVDIPVLRKDFIVGPYQIHEARAHGADVILLIVAALEQNVLASLLDRTESLGMTALVEVHTEEEADRALEAGASVVGVNARNLKTLQVERDTFSRIAPGLPTEIIRIAESGVRGTADLLAYAGAGADAVLVGEGLVTSGDPRAAVRELVTAGTHPSCPKPVR
>NZ_CP046257.1|WP_006359160.1|2063252_2064038_+|Trp-biosynthesis-associated-membrane-protein
MTSADQPAESSQPESSQPKPKSSRRPQMIAAVLMLATAAAFWGASRLTWATVSAEDGLSPQRAFDVKGSDWSPWLTPLALVYLAGIAAVLSVRGWGLRLVALLVAAGGVLAAFPAISLIAGGADSEYAADAGDIPDRYIVLYTDTQWLPAALVLLGTVCAVAAAVVLLRVAKGATMSSKYKTPAARREELETEIFADYERRKRAAAADSAKAGDTPADADADADAGTGGKDRRPGDDRDANERMMWDALDTGIDPTDPDER
>NZ_CP046257.1|WP_035755313.1|2061663_2063256_+|anthranilate-synthase-component-I
MSGVNAAAGAHTTSLAEFLDLARDHRVVPVTRKVLADSETPLSAYRKLAGDRPGTFLLESAENGRSWSRWSFIGAGAPSALTVVDGQAHWWGSVPVGAPEGGDALEVLAESLRVLKTDPLPGMPPLTGGFVGFMAYDMVRRLERLPETTVDDLGLPDMMMVLATDLAAVDHHEGTITLIANAVNWDGSDERVEEAYADALARLDRMTEALAAPASSTVSTFDRPTPDFTAQRTLEEYSEIVTSLVGEIEAGEAFQVVPSMRFEMDTEADPLDVYRVLRASNPSPYMYLLRMPGTEANSDTAAPDAIARKPFTIVGSSPEALVTVADRIATTHPIAGTRWRGATEEEDQLLGKGLLEDEKENAEHLMLVDLGRNDLGRVCVPGTVKVSDYRHIERYSHVMHLVSTVSGTLRDDKHALDAVTACFPAGTLTGAPKVRAMELIDEHEKTRRGLYGGIVGYLDFAGNADTAIAIRTALLARGQAYVQAGGGVVADSEPEYEYNEARNKATAVLNAVAAASTMNRVGETPSGDIA
>NZ_CP046257.1|WP_005196179.1|2061487_2061667_+|4-oxalocrotonate-tautomerase
MPLIQISQTPGLSDRVKRETIAAVTEAYAKATGKNPDSVWVTITEVPRTQWGVGGEPLG
>NZ_CP046257.1|WP_006359158.1|2061076_2061448_+|phosphoribosyl-AMP-cyclohydrolase
MALDPELASRLKRNADGLFSAVAQERSTGDVLMVAWMDDAALERTLATRKATYYSRSRQEYWVKGETSGHTQYVHDARLDCDGDTVLLVVDQVGAACHTGNHSCFDTESLSFGADARPVDSAQ
>NZ_CP046257.1|WP_035755324.1|2077169_2078048_+|acyl-CoA-thioesterase-II
MTVEQAGDLGKLLALLDVERRDEDVFIGQHPEQVTARTFGGQLLGQGVVAASRSLTRGNPPIHALHAHFIRGGDVTKPMEYHVDRFRDGKSFANRQVTAKQDGEQVFTMLVAFQDNTAGLEHAVEIPQVPYPEELPPLGEHFKGYEDRIATFVNALHPVDIRFANDPSWKAKEAGRKLTDNRVWMKADGVMPDDPVMHVAAMCYASDTTVLDSIITTHGLSWGIDRLFAATVNHSMWFHREFRFDDWLLYATRSPVATGSRGMGSGRFWTRDGTLATSVVQEALIKYFPPKK
>NZ_CP046257.1|WP_035755326.1|2078058_2078523_+|hypothetical-protein
MTIGQEMWLDPGPPLPRRTWQRRTRVPVIVGTTIAMVLFAAVALGALLLGVLRTPTFTAKGGVVADCATEVAAAPGGGQIARGTPVFVYDAAGGEVATTSLSGFLRSDTGCQLTFEVDGVEYTDAGYVVRVGESLSQPVSTAALQKGAVLRPFG
>NZ_CP046257.1|WP_155225212.1|2078724_2080707_+|ATP-binding-cassette-domain-containing-protein
MEYSIDWGNEVWASLKWLAIAFGIAAVAMLVIGFLLARFSRWGRPLWRVIGGFFTEPGTRLKAWGLAALLTVLALLGVRITVLFSYFSNDLFTGLQTAAEGLGAGGPQGAEMLQMGKDAFWHSMAVFGILATVHVVRTMIEIYVGAAFEINLRRWMTGGAAADWMDGRAFYRNRFVDLSSGLMRRKWFRRTSEPSQKPTDIHPGVDNPDQRIQADITNVASVGSSLLWGGGGSSTNGVLTAVASIASFSKILWDLSGPVTLLGVEIPRMMMWLVLVYVLVTSVVAFAIGRPLIRLNFWQERLTANFRYALVRVRDGAENIAFYRGERVEHNGLMSRFAAVIRNYWQIIHVQMAFVGWNFSVSQLAVVFPYLVQIPRFFDGQIKLGDMQQTASAFGEMHDALSFFRTAYDDFTGLRASIIRLDGLADADVKSRAMPEITTVDRDRAVRLADISVKTPTGDELIRALNISLDPGDALVVKGRSGSGKTTLLRGLAGLWPFIDGEFSRPPDAHTLFLSQMPYIPLGDLRTAVAYPALPDDVGDEAIKQALEQVFLPHLTGRLYDEEDWAKVLSPGEQQRVAFARILLTKPQAVFMDEATSAVDEGLEYALYQLVRTELPDTILVSVSHRSTTDQHHTEVLELTGDGAWTLSSIDSSPSLDKRS
>NZ_CP046257.1|WP_006360584.1|2080817_2082656_+|long-chain-fatty-acid--CoA-ligase
MTAADLITFPHETGVDVSTLPAAFQQTVTVRPDAVAIRTVGGIQQLTWSQYATRVEAIAGGLAALGVGRGDTVGIMLTNRPEFHLVDTAALHLGAVPFSIYNTSAPDQIEYLFGNAENRIVITEQVFLPVITAANTGVERIVVVDDVADGAISLDDVERTPPPEGFDFAASWQAVEPEDLATLIYTSGTTGPPKGVEITHRNIVAEMAALAEKLDVGFDDRSISYLPAAHIADRVSSHAANLMRGIQITTVPDPREIATALPEVHPTFFFGVPRVWQKIRAGIEAKVAEESSPVKRALAGWAFGVGASTAQARIDGKGSGLLGGVQHGIADKLVLHKVRAALGLDEVVFAGSGAAAIPVEVLKFFLGLGIPILEVWGMSETTGVSTMTTPDNLKIGTVGPPIRGMEVRLADDGELLVRGPVVMRGYRNQPEKTAETIDADGWLSTGDIAKIDDDGNVIIVDRKKELIINESGKNMSPTNIENAMKAASSLIGQVAAIGDSKPYVSALVVLDPEAVAVRAKRLSMPNADLAELSTHPEIVEEVSSAIRTGNGKLSRVEQVKRFTIVPAAWDPGGDELTPTMKLRRNPIAAKYAAEIGALYESEPGGSVVDLRS
>NZ_CP046257.1|WP_006360585.1|2082652_2083090_+|hypothetical-protein
MTADDDSAGPELGPVDYVVVEWAGTQPTGEALPYLMDLIDRGIVRLIDIVFVSKATDGTIAELGIGELGAEFAIFDGAATSILDDTDIREAAAALEPGSSAAILVWENLWAAPFATALRNNGGRVVASGRIPVDALLETLDAIEE
>NZ_CP046257.1|WP_006360586.1|2083103_2083439_+|SHOCT-domain-containing-protein
MPGLIRGVARTAVISGTATAVSNRVSRRQASRWAQQGTVTQQDPTAQQYPPPQYAPTPYPESPPPPQPPRPPAQSSSTDTITALKELGALYQQGILTEAEFAAQKAKILGM
>NZ_CP046257.1|WP_006360587.1|2083460_2084261_-|ethanolamine-ammonia-lyase-subunit-EutC
MSTPDRSPVSDGDDVWAAMRRTTQARIGLGRAGNSLPSRRVLEFQAAHAAARDAVHEPLDAEAVAESLADLDLGDPVVVTSRASDRGEYLRRPDLGRMPEDLSALTECGAEIGIVIADGLSPRAVVDHAHGLVAALLDAFEDRYTIAPPVIATQARVALGDHIGEALGATTLIVIIGERPGLSVADSLGIYLTHLPRPGRTDADRNCISNIHPPDGLHYEVAARITTALVDGARKLGRSGVALKDTSRQAARENLDDADELTVEPS
>NZ_CP046257.1|WP_042376157.1|2084257_2085667_-|ethanolamine-ammonia-lyase-subunit-EutB
MRFTQTISGTTYEFDGLVELMAKATPRRSGDELAGCAATSGAERAAAAWQLADVPLSEFLVDLLVPYESDEVTRLIVDTHDRAAFDEISHLTVGGFRDWLLEISTRADAAERIARISPAVTPEMAAATSKIMRNQDLILVASAIRVTSAFRTTIGLPGRIATRLQPNHPTDDPRGIAAATLDGLLMGCGDAVIGINPASDSPQATADLLHMLDEIRQRFEIPMQSCVLSHVTTTVDLIGQNVPVDLVFQSIAGTEGANTGFGVNLSILQEANEAGRSLRRGTVGDNVMYLETGQGSALSAGAHLGTGGKPVDQQTLETRAYAVARALDPLLINTVVGFIGPEYLYDGKQIIRAGLEDHFCGKLLGLPMGVDVCYTNHAEADQDDMDTLLTLLGVAGAAFVIAVPGADDVMLGYQSLAFHDALYVRQALGLRPAPEFEAWLARLGMSDADGRILPVDPASSPLLPLAAGR
>NZ_CP046257.1|WP_005196147.1|2085900_2086692_+|dihydroxynaphthoic-acid-synthetase
MDYEDIDYTVEGPTAIITMNRPHRYNAFRAKTVEEMINAFRRAWADNGVQAVILTGAGEKAFCTGGDVKQRAETGDYGPSESGMFEIGNLHKTIRDIPKPVIAAVNGLAIGGGHVLHVLCDLTIAADTARFGQSGPKVGSFDAGFGSAFLARVVGEKRAREIWYLCRQYDAETAERWGLVNWVVPAADLLDEAKKIAAEIAEKSPTTLRFLKQSFNADTDHQAGLSNLAMSALDLFTHSPEGLEGANAFAEKRTPQFNQYVGA
>NZ_CP046257.1|WP_006360589.1|2086724_2087474_+|SDR-family-oxidoreductase
MSDKHIAVVTGAGSGIGKAIALGFAAEGTTVVAADLDLDAAKRTAEEAGSIIPMAVDVADRAKVDELRDAVNAEVGVPDILVNAAGWDRTDQFLNATTEFAEKVVAINYLGPVHMASAFLPGMVEASKADGWQGGRVVNLASDAGRVGSAGETIYAGAKGGVIALSKSLAREMARYQITVNAVCPGPTDTPLFQAQPEKLKEALVKAIPFRRLARPDEVAAPVLFFASPAASFITGQVISVSGGLTMAG

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Crispr_ID: NZ_CP046257_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046257_5

3310374-3310451

Orphan

Consensus_repeat	Method
CCGGAGCAGACCAGCGATCCCGGCG	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NZ_CP046257_5

>merge|NZ_CP046257|5|3310374-3310451|CRISPRCasFinder
CCGGAGCAGACCAGCGATCCCGGCGTGGCCTAGTTCGGCACCGGACCGCCGCACCCGGACAGACCAGCGATCCCGGCG

>NZ_CP046257|5|5|3310374-3310451|CRISPRCasFinder
CCGGAGCAGACCAGCGATCCCGGCG	TGGCCTAGTTCGGCACCGGACCGCCGCA
CCCGGACAGACCAGCGATCCCGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046257.1\|WP_006356782.1\|3313285_3314554_+\|beta-ketoacyl-ACP-synthase	unknown	unknown	gnl\|CDD\|236129
NZ_CP046257.1\|WP_155225391.1\|3301551_3302376_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|274422
NZ_CP046257.1\|WP_006356783.1\|3311950_3312859_+\|ACP-S-malonyltransferase	unknown	unknown	gnl\|CDD\|223408
NZ_CP046257.1\|WP_035752746.1\|3319231_3320836_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|169098
NZ_CP046257.1\|WP_006356781.1\|3314624_3316076_+\|propionyl-CoA-carboxylase-subunit-beta	unknown	unknown	gnl\|CDD\|227136
NZ_CP046257.1\|WP_127962808.1\|3298526_3299354_+\|spermidine-synthase	unknown	unknown	gnl\|CDD\|223498
NZ_CP046257.1\|WP_075864044.1\|3303572_3304649_+\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187556
NZ_CP046257.1\|WP_155225393.1\|3320923_3321724_-\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|235852
NZ_CP046257.1\|WP_042377151.1\|3304689_3305397_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP046257.1\|WP_006356780.1\|3316409_3316928_-\|DUF3145-domain-containing-protein	unknown	unknown	gnl\|CDD\|378644
NZ_CP046257.1\|WP_006356778.1\|3317922_3319053_-\|NDMA-dependent-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|274905
NZ_CP046257.1\|WP_005200177.1\|3312983_3313286_+\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|179197
NZ_CP046257.1\|WP_040003887.1\|3306749_3307370_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046257.1\|WP_155225392.1\|3302533_3303517_+\|WYL-domain-containing-protein	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NZ_CP046257.1\|WP_035752734.1\|3297508_3298486_-\|cobalamin-biosynthesis-protein	unknown	unknown	gnl\|CDD\|234919
NZ_CP046257.1\|WP_006356779.1\|3317055_3317874_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP046257.1\|WP_005200172.1\|3306147_3306576_-\|DUF3052-domain-containing-protein	unknown	unknown	gnl\|CDD\|378615
NZ_CP046257.1\|WP_006356784.1\|3310480_3311755_+\|PucR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225306
NZ_CP046257.1\|WP_006356787.1\|3305668_3306151_-\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239316
NZ_CP046257.1\|WP_035752737.1\|3299458_3301483_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916

Protein	Function_ID	Function_description	E-value
NZ_CP046257.1\|WP_006356782.1\|3313285_3314554_+\|beta-ketoacyl-ACP-synthase	gnl\|CDD\|236129	PRK07910, PRK07910, beta-ketoacyl-ACP synthase.	0
NZ_CP046257.1\|WP_155225391.1\|3301551_3302376_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	9.09153e-21
NZ_CP046257.1\|WP_006356783.1\|3311950_3312859_+\|ACP-S-malonyltransferase	gnl\|CDD\|223408	COG0331, FabD, (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism].	1.99089e-72
NZ_CP046257.1\|WP_035752746.1\|3319231_3320836_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|169098	PRK07786, PRK07786, long-chain-fatty-acid--CoA ligase; Validated.	0
NZ_CP046257.1\|WP_006356781.1\|3314624_3316076_+\|propionyl-CoA-carboxylase-subunit-beta	gnl\|CDD\|227136	COG4799, COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism].	0
NZ_CP046257.1\|WP_127962808.1\|3298526_3299354_+\|spermidine-synthase	gnl\|CDD\|223498	COG0421, SpeE, Spermidine synthase [Amino acid transport and metabolism].	1.43388e-21
NZ_CP046257.1\|WP_075864044.1\|3303572_3304649_+\|NAD(P)H-binding-protein	gnl\|CDD\|187556	cd05245, SDR_a2, atypical (a) SDRs, subgroup 2. This subgroup contains atypical SDRs, one member is identified as Escherichia coli protein ybjT, function unknown. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif consensus that generally matches the extended SDRs, TGXXGXXG, but lacks the characteristic active site residues of the SDRs. This subgroup has basic residues (HXXXR) in place of the active site motif YXXXK, these may have a catalytic role. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.23926e-79
NZ_CP046257.1\|WP_155225393.1\|3320923_3321724_-\|enoyl-CoA-hydratase	gnl\|CDD\|235852	PRK06688, PRK06688, enoyl-CoA hydratase; Provisional.	3.77085e-68
NZ_CP046257.1\|WP_042377151.1\|3304689_3305397_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	0.000866265
NZ_CP046257.1\|WP_006356780.1\|3316409_3316928_-\|DUF3145-domain-containing-protein	gnl\|CDD\|378644	pfam11343, DUF3145, Protein of unknown function (DUF3145). This family of proteins with unknown function appear to be restricted to Actinobacteria.	1.99726e-86
NZ_CP046257.1\|WP_006356778.1\|3317922_3319053_-\|NDMA-dependent-alcohol-dehydrogenase	gnl\|CDD\|274905	TIGR03989, Zn-dependent_alcohol_dehydrogenase_class_III, NDMA-dependent alcohol dehydrogenase, Rxyl_3153 family. This model describes a clade within the family pfam00107 of zinc-binding dehydrogenases. The family pfam00107 contains class III alcohol dehydrogenases, including enzymes designated S-(hydroxymethyl)glutathione dehydrogenase and NAD/mycothiol-dependent formaldehyde dehydrogenase. Members of the current family occur only in species that contain the very small protein mycofactocin (TIGR03969), a possible cofactor precursor, and radical SAM protein TIGR03962. We name this family for Rxyl_3153, where the lone member of the family co-clusters with these markers in Rubrobacter xylanophilus. [Unknown function, Enzymes of unknown specificity].	0
NZ_CP046257.1\|WP_005200177.1\|3312983_3313286_+\|acyl-carrier-protein	gnl\|CDD\|179197	PRK00982, acpP, acyl carrier protein; Provisional.	1.38136e-26
NZ_CP046257.1\|WP_155225392.1\|3302533_3303517_+\|WYL-domain-containing-protein	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	9.28576e-46
NZ_CP046257.1\|WP_035752734.1\|3297508_3298486_-\|cobalamin-biosynthesis-protein	gnl\|CDD\|234919	PRK01209, cobD, cobalamin biosynthesis protein.	1.69866e-114
NZ_CP046257.1\|WP_006356779.1\|3317055_3317874_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.5926e-34
NZ_CP046257.1\|WP_005200172.1\|3306147_3306576_-\|DUF3052-domain-containing-protein	gnl\|CDD\|378615	pfam11253, DUF3052, Protein of unknown function (DUF3052). This family of proteins with unknown function appears to be restricted to Actinobacteria.	2.18824e-62
NZ_CP046257.1\|WP_006356784.1\|3310480_3311755_+\|PucR-family-transcriptional-regulator	gnl\|CDD\|225306	COG2508, COG2508, Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism].	9.15941e-34
NZ_CP046257.1\|WP_006356787.1\|3305668_3306151_-\|peroxiredoxin	gnl\|CDD\|239316	cd03018, PRX_AhpE_like, Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater similarity to 2-cys PRXs than 1-cys PRXs. PRXs are thiol-specific antioxidant (TSA) proteins that confer a protective role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF. The first step of catalysis is the nucleophilic attack by the peroxidatic cysteine on the peroxide leading to the formation of a cysteine sulfenic acid intermediate. The absence of a resolving cysteine suggests that functional AhpE is regenerated by an external reductant. The solution behavior and crystal structure of AhpE show that it forms dimers and octamers.	1.89439e-59
NZ_CP046257.1\|WP_035752737.1\|3299458_3301483_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.90082e-111

>NZ_CP046257.1|WP_040003887.1|3306749_3307370_-|hypothetical-protein
MLGTGEARPGRSGHRGVRASMTVGMAFGGIMLSACASTVGGEGVAAPGEVAVYRSEVSASAAAQVRTEGVELCRESMSSMVVMVRGYNTFIKRLNTTHSYPEVGDLADKARASLIAGADQIRPKITASAPVDVATPTRTFLDSTARLENAIRKEQRTELNTVSGQWTRDKARLLEVCGEYTPVPAASSATPRSSVTTTPVPTSPGR
>NZ_CP046257.1|WP_005200172.1|3306147_3306576_-|DUF3052-domain-containing-protein
MVAATDGTGSNAQKLGLKAGLVVQEVGWDEDTDDELRADIEDAIDAEMVDEDADDVVDVVVLWWREGDGDLVDALMDAIGPLAEDGYVWVFSPKTGKPGYVDPSEIAEAAPTAGLTQTSAISLGDWSAARLVQPKARSGKKA
>NZ_CP046257.1|WP_006356787.1|3305668_3306151_-|peroxiredoxin
MSDALPTAPLSVGDQAPDFELRDQNNQLVSLQALRAERNVLVVFFPLAFTGTCQGELGYIRDQQPRFENDDVTTVTISVGPSPTHKVWSAAQGFLFPLLSDFWPHGEVAKAYGVFNSDRGYANRGTFLVNREGVIVYADMVGPGEVRENNVWDKALGAVG
>NZ_CP046257.1|WP_042377151.1|3304689_3305397_+|CPBP-family-intramembrane-metalloprotease
MLVTALARDLYNSIAADRDPDPGSHYVRRRWLVGVFLVIGAIVLGVSLRVEPGDTAFYPLTVALAAVWTVGALTSGKLRLGAYSPTASRPPDRLGAVGLGVVVGLAVGAAFVVGGLLVRMIPGVSDLANKVLAFADYGSLAIVTLITVVNGLAEELFFRGSVYSAARPHNPVLVSTVIYVLVTMASGNVMLGFAGAVLGTVCAILRRSTAGVLAPAITHVIWGAIMVLALPPIFA
>NZ_CP046257.1|WP_075864044.1|3303572_3304649_+|NAD(P)H-binding-protein
MRLLITGATGYVGSRLVCALLRQGHEVVVTSRDTRKLDRFGWSSDVTKVAMDADDPISVKKAMTDAGHLDAIYYLVHAIGQADFASGDRDAARNVAEAARDAGVGRIIYLGGFVPGDAKLSSHLQSRADVAEGLVIEDGPELVWLRAAVIIGAGSTSFEIIRYMADRLPVIPEPAWITNEMDPISIRDAIHYLVAACESSLPPGEYDISGPDHARYISILHEYISAVRFPRLRLPVFGVSTRLAGRLGGMFVPVPASLTEELVTSLDHSMTASEHSIRELVPPPEGGLTPMRDAVRASVESPYPRSVCDLHDLHHLADTDPAWAGGDWLRVKRSIGGTIGGTLRVSAKIAGALLPTRP
>NZ_CP046257.1|WP_155225392.1|3302533_3303517_+|WYL-domain-containing-protein
MLETSARLLALLSLLQTRREWSGKELAERLDITTRTVRRDIDKLRELGYPVDANVGARGGYRLGAGAEMPPLLLDDQEVLAVALGLDAVTTGAVADMAEASAGALAKLRQVMPSRLQHRLDALRIEAIPREAPTSAVPAERLTDIATACHRHERLRFDYRRNDGEESRREVEPFRLVRSGNRWYLVGFDLARDDWRSFRVDRMDPKIPTGPRFTPREPPEGGAAAFVARGLGAVQQQATARIRVHLPLDEVAPMIHHYWGALESGDENSCEVTVYSTSLTAIARWMYAFDADFTVLEPDELRVELGAVAEYHDQVAERYRRAMSARP
>NZ_CP046257.1|WP_155225391.1|3301551_3302376_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MPTTILPLAEVTEGLIAQWAAIADVAAALTDEQWSAASVLPGWTNADIVAHIIGTESMLDGRDVEATRTVSALDHVRNPIGELNEKWVDHYRPKPRAEVLAALDEIITVRTAALRAMTQEQFDAPSMTPAGADTYGRFMRIRIFDCWTHEIDLRDGTDGSAVTDPVPASLALDEIGASLPFVVGKRADAPKGSKVLFAITGLSARTVRIDVGDRASLVEEFDGGDASADVRLRIDAANLARCAGGRRDASPDAVEIDGDAALGNAILNRMNYVI
>NZ_CP046257.1|WP_035752737.1|3299458_3301483_+|protein-kinase
MTDPSSRAGTTLGPYRIDRLLGRGGMGEVYEAYDTGKERRVALKVLPPHLVHDNDFRERFERESKTAAKLSDPHVIPIHDWGEKDGVLFIDMRLVDGQDLRKVLDSGPLAPDRAIRILGQVAAALDAAHRDGLVHRDIKPDNILVDADDFAYLVDFGIAQGATDSRLTQVGTALGTLAYMAPERFGDEPAGPGSDNYALACVLYECVTGQTPFPAKTDQGLMTAHITKPPPQTGGPLDPVIARGLAKDPAQRFPSARELIQAASDALSGSPSASATRPQTPPAEQAPPTVVPQPIPPAGPTPRPHTPRPPQSQPPAAHPTPGGSMASDPTMVRGLNSGPNVHGPQHSPGSAGGYGPPPGPFGPQGFSGPQFHSEPSPSGPQSFSGPQSHSGPQSFSGPQSFSGPQSLSGPNQWGGTPTPPPRKSKTGRNIAIAIGVGVVVIALAVTGIVVALSGGGDDPPEPGTSSQAMPAGTVACDYPTRTVVGGITQPAPASTQPNTGTVDAQIPIAAQGTITMTLNRAEAPCNVGAMVALIKSGFYDGSKCHRASAKYLICGSSGGKEGTNPGWTSPDELPEGLPSAGTDTNGIPQVTYPRGTVGILDLPDDEGATGSTTFFMLADDTDLPLTYSIVGTMDASGLAVLDKIVAGGFTPTKPGAQSGPPNQNLLIQKATVGE
>NZ_CP046257.1|WP_127962808.1|3298526_3299354_+|spermidine-synthase
MARSSAEPTPGRHVIDTGVAELARDTIAGGWLLTVNGAHSSHIDPDDPTVLDFEYLRQMAAVIAERHPASDRLRVLHLGGAACALARYLDHQYPDARQVAVEVDGELARLVREWFDLPRAPKLRIRVGDAREVVTSLQPGTREVIVRDAFAGDRTPAHLTTREFTSAVHDVLVPGGLYLANCGDSRDLAGARAEAATVASVFDHLLLIADAAMFKGRRTGNIVIVGSDAPLDASATLVRTLLSDPLPAQILSGAKARDFARGPGLADSDLAADRP
>NZ_CP046257.1|WP_035752734.1|3297508_3298486_-|cobalamin-biosynthesis-protein
MPLTREQRNRPARRALSNTAGLIVGFLLDEALGDPSTGHPVAGFGRLTSVLEHRMYRDSRAAGAGLVAVAAGGVVGAAVAASAGRRAPASVALTAASTWIALGGTSLCRVGDAVADALESDDIDAARALIPSLCGRDPMSLDEAGICRAALESIAENTSDATVGPLFWGAVAGVPGILGYRAVNTLDAMVGYRNERYRDFGWAAARLDDVANILPARLAGVLIVLVSGAPRRAAEAWRRDSHAHPSPNAGVVEAAFAGALGVQLGGRTVYPHGVEQRPTLGSGPAPKPADLRAAVTVSRRVQRATVAACVAGCLLRVAVSRRSAG
>NZ_CP046257.1|WP_006356784.1|3310480_3311755_+|PucR-family-transcriptional-regulator
MSDARVNQPTTPPADVFGERGAHVPAPATVHDALPDTLLRRVKQYSGRLATEAVHSMQDQLPYFGDLDAAQRASVQLVVQTAVVNFVEWIQDPEGNVKFTVQAFQVVPQDLARRITLLQTVEMVRVAMEFFEKWLPLLARNDAQLRALTESVLRYGREIGFAAAAIYASAAESRGAWDSRLEALVVDAVVRGDTGPQLLSRAAALNWDSDAPATVIVGTPPPEQNVSVPLAIHNTARHFDRSALSVVQGSVLVAIVSGPARPTEKFVSALLSHFADGPVVIGPTMPNLGSAHASAAEAMAAIEAVVGWPSAPRPVHSLELLPERALNGDESAVAALVESVVSPLSTGGTTLTTTLEAYLDSGGSVESCARVLYIHPNTVRYRLKKIAEITRRDPTNPRDAYVLRIATTVGRLTHLRHKSDPPAP
>NZ_CP046257.1|WP_006356783.1|3311950_3312859_+|ACP-S-malonyltransferase
MLSLLAPGQGSQTPGMLTPWLDLPGTRDQIATWSKLTQLDLERLGTTATAEEITDTAVTQPLVVVAALLAFDEVRKNGELPADAAVAGHSVGELAAAAITGVISADEAVTLAAIRGAEMAKACALVPTTMAAVLGGDEAAVLARLEELELVPANRNAVGQIVAAGAVEKIDELIASPPEKARIRKLAVAGAFHTHFMAPAQDAVAAAAAKITPADPNRTLLSNSDGQPVTNGVDALTKLVGQVTRPVRWDLCSAYLRDNSATAVVELPPAGTLVGIAKRELKGTPSLALKEPRDIAKIAELG
>NZ_CP046257.1|WP_005200177.1|3312983_3313286_+|acyl-carrier-protein
MAATQEQLIAGIAEIIEEVTGIEPSEVTMEKSFVDDLDIDSLSMVEIAVQTEDKYGVKIPDEDLAGLRTVGDAVSYIQKLESENPEAAAAIKAQVEADQN
>NZ_CP046257.1|WP_006356782.1|3313285_3314554_+|beta-ketoacyl-ACP-synthase
MSSPSLRDYSTLGGNFPSVVVTSMVATTSLGEDLDSTWKNLLAGESGIRELTDDFITKYNLPVRIGGRLLKDPSEEVTRVESRRMAYVERIAHVLSKRLWTQAGEPEVDPDRLAVVIGTGQGGGDAMIDAVKAMEGTGNYRKVSPLAVSMAMPNGPAAVVGLNIGARAGVITPVSACSSGAEAIAHAWRHIVMGDADMVVTGGVEGQIDAVPIAAFSMMRAMSTRNEDPAAASRPFDKDRDGFVFGEGAAMLILEREEHARARGARIHARLLGSGITSDGFHLVAPDPSGQGNARAMTRALQTAGLQKSDITHINAHATSTPIGDTAEAAGITAAIGQHAAIYAPKSALGHSIGAVGALESVLTIKSVEEGVIPPTLNLENQDPECDIDVVHGEPRYGQIDYAINNSFGFGGHNVALAFGRY
>NZ_CP046257.1|WP_006356781.1|3314624_3316076_+|propionyl-CoA-carboxylase-subunit-beta
MTTLAPMAGREEAADPRDPLLRLTNFFDEGTMSLLHPRDKSGVQAAVGLVNGVRTVSYCTDGTVMGGAMGVVGCAHIVNAIDTAISEQAPVIGIWHSGGARLAEGVEALHAVGQVFEAMVRASGYIPQISVVVGFAAGGAAYGPALTDIVIMAPAGRVFVTGPDVVRSVTGEDVDMESLGGPTTHGKKSGVCHIVADSESDALWRARRLVSTFSQQGHFNRELAAAGDTDLKALLPESARRAYDVHPVVEKLLDTALAADGETEISSFEELQAKWAPNIVIGFGRLSGRSVGVIANNPLRMGGCLNSESAEKASRFVRLCDAFGIPLIVLTDVPGYLPGVGQEWNGVVRRGAKLLHAFAECSVPRVTLVTRKIYGGAYIAMNSRALGATAVFAWPGSEVAVMGAKAAVGILHKKALAAAPDDEREALHDRLAAEHEAIAGGVGRAQSIGVVDEIIDPARTRSIIAEALAAAPARRGRHKNIPL
>NZ_CP046257.1|WP_006356780.1|3316409_3316928_-|DUF3145-domain-containing-protein
MRNLNQFADMTTGVVYIHSAPVALCPHVEWALSSTLNARANLKWSAQDAEPGMQRATVDWAGPVGTAARLVTALREWSALRFEVTENPSEGVDGERYSYVPGLGLWRGSTSANGDVIIGENQLRSMIESQPDSAGLAGELEAALGSAWDDALEQYRMGGAGAEVTWLQQRVG
>NZ_CP046257.1|WP_006356779.1|3317055_3317874_-|serine-hydrolase
MSVLESLTEWPVDNVSAAIITRDGVAEEFGDPVRVYELASVTKLLVAEAILVAVEEGAVELDDPAGPPGATIRHLLAHASGLAFDSRDLEAGVGEKRIYSSAGFEILAETVEQAAGIGFAEYLADAVCAPLGMKSTELYGPAGHGARSTTTDLAHFAQELLAPRLLAPETLADATSVQFPGLDGFVPGYGRHRPNDWGLGFEIRSAKSPHWTGTGNSPRTFGHFGQAGTYLWVDPELQAACVVLTDRAFGPWAKPLWSEFNDRVVSELSSQK
>NZ_CP046257.1|WP_006356778.1|3317922_3319053_-|NDMA-dependent-alcohol-dehydrogenase
MKTKGALLREHNKPWAIEDIEIGDPKAHEIKIKMEAAGMCHSDHHLMTGGIPMAGFPILGGHEGAGVVAEVGEGVTDFEVGDHVVLSFIPSCGKCPSCQSGMANLCDFGAMLLQGEAVSDNTFRIQTAAGENVYPMTLLGTFAPYMVVHEASAVKIDKDIPFEVAALCGCGIPTGYGSSTRSGDVRPGEDVAIVGVGGVGTAALQGAVISGARNVFAIDPVEWKREQALKFGATAAFASVEEAAMAIAETTHGGMCQKVIVTVGEVHGKDVDLWMGITAKGGTCVLTGMGNMLESDVTLNLAMLTLLQKNLQGSIFGGANPKLDIPQLLSMYKIGKLNIADMITRQYRLDQINEGYQDMLDGRNIRGVIRYTEEDW
>NZ_CP046257.1|WP_035752746.1|3319231_3320836_-|long-chain-fatty-acid--CoA-ligase
MTATVDTVTDLATEPLRSRRNHWNNQIKRHAFMNPEGPALKFQGEVTTWKELDERTRAFAAALTRRGVQFGDRILVVLLNRSEYVETVLGANLIGAIPVPVNIRMSPAEIAFLVNDSGAKVIVTETMLAPLADAVAASTNAIDHIVVVGGSDNDSHLDFEALVAEDSSDLPEIDVPEETVALIMYTSGTTGKPKGAMLTHTNMQAQAVTCLQALQTRSDDIGSCVAPMFHIAGLGAMAPLFYMGALSVIHPLGAFDPNDMLDTIEKEGTTSIFLVPAQWQAVCAAQQAKPRDLKLRVTSWGAAPASDTVLRAMNETFPDALNVAVFGQTEMSPITCVLEGKDAMNKIGSIGKVVPAVTARIIDPEGNDVKQGEVGEIVYHGPNMMKGYWQNEQGTADAFACGWFHSGDLVREDEDGFLYVVDRAKDMIISGGENIYCAEVENVLFGHPSISEAAIIGRAHEKWGEVPVAVVVLAEGVTDLALADLEPYLNENLARFKHPKGLVIVDELPRNAGGKVVKPTLRASYGSKDAGLAD
>NZ_CP046257.1|WP_155225393.1|3320923_3321724_-|enoyl-CoA-hydratase
MSDETSQAIVTSVDDRGVARLTISRPEKMNALDTEANHGIKAAMEEWSKRDDVRVIVLDGAGGSFSAGADVVSINSQSTANGSSGLDPDQARGIISVGSELARAVRSSQVPVIASADGPAAGIGASLALAADLIYTTKRSYFLLAFINIGLMPDGGASMLFTSAVGRVRANELALLGEKLRAPEALAAGLVDGVYDDRPALDEVVDKVAAKLAGKSRSALRLTKSALDAHTMSGFEAAIERELEGQTELLQSPEFQAAIAAFAGKK

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Crispr_ID: NZ_CP046257_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046257_6

3886398-3886565

Orphan

Consensus_repeat	Method
NCGGCNNCGGCGGCAGCG	CRT

4 spacers

The CRISPR arrays of NZ_CP046257_6

>merge|NZ_CP046257|6|3886398-3886565|CRT
CCGGCGGCGACTCGGGCGGTGGTGACTCCAGCGGGGGTGACTCCGGCGGCAGCGGCAGCGGCAGTGGCTCGGGCGGTGGAGACTCCGGCGGCAGCGATTCCAGCGGAAGCGGTAGCGGCTCCGGCGGCAGCGGTAGCGGGTCGGGCGGCAGCGGTTCCGGCGGCAGCG

>NZ_CP046257|6|1|3886398-3886565|CRT
CCGGCGGCGACTCGGGCG	GTGGTGACTCCAGCGGGGGTGACT
CCGGCGGCAGCGGCAGCG	GCAGTGGCTCGGGCGGTG
GAGACTCCGGCGGCAGCG	ATTCCAGCGGAAGCGGTA
GCGGCTCCGGCGGCAGCG	GTAGCGGGTCGGGCGGCA
GCGGTTCCGGCGGCAGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046257.1\|WP_006360211.1\|3883863_3884355_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046257.1\|WP_005197641.1\|3890021_3890207_-\|type-Z-30S-ribosomal-protein-S14	unknown	unknown	gnl\|CDD\|181216
NZ_CP046257.1\|WP_035754995.1\|3880505_3881231_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369213
NZ_CP046257.1\|WP_035754991.1\|3885415_3885871_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176874
NZ_CP046257.1\|WP_006360210.1\|3882423_3883833_+\|stress-protein	unknown	unknown	gnl\|CDD\|376704
NZ_CP046257.1\|WP_005197623.1\|3878200_3878848_-\|30S-ribosomal-protein-S5	unknown	unknown	gnl\|CDD\|234790
NZ_CP046257.1\|WP_005197644.1\|3891132_3891501_-\|50S-ribosomal-protein-L14	unknown	unknown	gnl\|CDD\|180117
NZ_CP046257.1\|WP_035754990.1\|3890208_3890811_-\|50S-ribosomal-protein-L5	unknown	unknown	gnl\|CDD\|178791
NZ_CP046257.1\|WP_035754977.1\|3908748_3909573_+\|anti-sigma-factor	unknown	unknown	gnl\|CDD\|378389
NZ_CP046257.1\|WP_035755178.1\|3881363_3881963_+\|DUF4262-domain-containing-protein	unknown	unknown	gnl\|CDD\|379457
NZ_CP046257.1\|WP_155225486.1\|3892073_3905867_+\|amino-acid-adenylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|237108
NZ_CP046257.1\|WP_155225487.1\|3906101_3907328_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|130256
NZ_CP046257.1\|WP_035754993.1\|3884351_3885209_-\|ParA-family-protein	unknown	unknown	gnl\|CDD\|224113
NZ_CP046257.1\|WP_005197643.1\|3890812_3891130_-\|50S-ribosomal-protein-L24	unknown	unknown	gnl\|CDD\|234566
NZ_CP046257.1\|WP_006360199.1\|3879852_3880251_-\|30S-ribosomal-protein-S8	unknown	unknown	gnl\|CDD\|234658
NZ_CP046257.1\|WP_035754986.1\|3907317_3908100_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|366444
NZ_CP046257.1\|WP_155225488.1\|3908147_3908756_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|182015
NZ_CP046257.1\|WP_005197647.1\|3905866_3906124_+\|MbtH-family-protein	unknown	unknown	gnl\|CDD\|377081
NZ_CP046257.1\|WP_006360198.1\|3879302_3879839_-\|50S-ribosomal-protein-L6	unknown	unknown	gnl\|CDD\|235495
NZ_CP046257.1\|WP_006360197.1\|3878894_3879299_-\|50S-ribosomal-protein-L18	unknown	unknown	gnl\|CDD\|235524

Protein	Function_ID	Function_description	E-value
NZ_CP046257.1\|WP_005197641.1\|3890021_3890207_-\|type-Z-30S-ribosomal-protein-S14	gnl\|CDD\|181216	PRK08061, rpsN, type Z 30S ribosomal protein S14.	3.70864e-35
NZ_CP046257.1\|WP_035754995.1\|3880505_3881231_-\|hypothetical-protein	gnl\|CDD\|369213	pfam07110, EthD, EthD domain. This family consists of several bacterial sequences which are related to the EthD protein of Rhodococcus ruber. In Rhodococcus ruber, EthD is thought to be involved in the degradation of ethyl tert-butyl ether (ETBE). EthD synthesis is induced by ETBE but it's exact function is unknown, it is however thought to be essential to the ETBE degradation system.	0.00895312
NZ_CP046257.1\|WP_035754991.1\|3885415_3885871_+\|hypothetical-protein	gnl\|CDD\|176874	cd08865, SRPBCC_10, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	2.65836e-21
NZ_CP046257.1\|WP_006360210.1\|3882423_3883833_+\|stress-protein	gnl\|CDD\|376704	pfam01987, AIM24, Mitochondrial biogenesis AIM24. In eukaryotes, this domain is involved in mitochondrial biogenesis. Its function in prokaryotes in unknown.	1.75044e-35
NZ_CP046257.1\|WP_005197623.1\|3878200_3878848_-\|30S-ribosomal-protein-S5	gnl\|CDD\|234790	PRK00550, rpsE, 30S ribosomal protein S5; Validated.	3.47425e-95
NZ_CP046257.1\|WP_005197644.1\|3891132_3891501_-\|50S-ribosomal-protein-L14	gnl\|CDD\|180117	PRK05483, rplN, 50S ribosomal protein L14; Validated.	9.16471e-85
NZ_CP046257.1\|WP_035754990.1\|3890208_3890811_-\|50S-ribosomal-protein-L5	gnl\|CDD\|178791	PRK00010, rplE, 50S ribosomal protein L5; Validated.	9.52981e-124
NZ_CP046257.1\|WP_035754977.1\|3908748_3909573_+\|anti-sigma-factor	gnl\|CDD\|378389	pfam10099, RskA, Anti-sigma-K factor rskA. This domain, formerly known as DUF2337, is the anti-sigma-K factor, RskA. In Mycobacterium tuberculosis the protein positively regulates expression of the antigenic proteins MPB70 and MPB83.	2.95307e-21
NZ_CP046257.1\|WP_035755178.1\|3881363_3881963_+\|DUF4262-domain-containing-protein	gnl\|CDD\|379457	pfam14081, DUF4262, Domain of unknown function (DUF4262). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 147 and 227 amino acids in length. Some members may be incorrectly annotated as the KatG protein.	1.09377e-26
NZ_CP046257.1\|WP_155225486.1\|3892073_3905867_+\|amino-acid-adenylation-domain-containing-protein	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
NZ_CP046257.1\|WP_155225487.1\|3906101_3907328_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|130256	TIGR01188, drrA, daunorubicin resistance ABC transporter ATP-binding subunit. This model describes daunorubicin resistance ABC transporter, ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	3.52982e-97
NZ_CP046257.1\|WP_035754993.1\|3884351_3885209_-\|ParA-family-protein	gnl\|CDD\|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	6.20641e-42
NZ_CP046257.1\|WP_005197643.1\|3890812_3891130_-\|50S-ribosomal-protein-L24	gnl\|CDD\|234566	PRK00004, rplX, 50S ribosomal protein L24; Reviewed.	1.20048e-42
NZ_CP046257.1\|WP_006360199.1\|3879852_3880251_-\|30S-ribosomal-protein-S8	gnl\|CDD\|234658	PRK00136, rpsH, 30S ribosomal protein S8; Validated.	1.70452e-80
NZ_CP046257.1\|WP_035754986.1\|3907317_3908100_+\|ABC-transporter-permease	gnl\|CDD\|366444	pfam01061, ABC2_membrane, ABC-2 type transporter.	2.17546e-17
NZ_CP046257.1\|WP_155225488.1\|3908147_3908756_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|182015	PRK09646, PRK09646, ECF RNA polymerase sigma factor SigK.	1.77437e-67
NZ_CP046257.1\|WP_005197647.1\|3905866_3906124_+\|MbtH-family-protein	gnl\|CDD\|377081	pfam03621, MbtH, MbtH-like protein. This domain is found in the MbtH protein as well as at the N-terminus of the antibiotic synthesis protein NIKP1. MbtH and its homologs were first noted in gene clusters involved in non-ribosomal peptides and other secondary metabolites by Quadri et al. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues. The structure of the PA2412 protein shows it adopts a beta-beta-beta-alpha-alpha topology with the short C-terminal helix forming the tip of an overall arrowhead shape. MbtH proteins have been shown to be required for the synthesis of antibiotics, siderophores and glycopeptidolipids.	1.25169e-32
NZ_CP046257.1\|WP_006360198.1\|3879302_3879839_-\|50S-ribosomal-protein-L6	gnl\|CDD\|235495	PRK05498, rplF, 50S ribosomal protein L6; Validated.	8.89976e-114
NZ_CP046257.1\|WP_006360197.1\|3878894_3879299_-\|50S-ribosomal-protein-L18	gnl\|CDD\|235524	PRK05593, rplR, 50S ribosomal protein L18; Reviewed.	1.37482e-53

>NZ_CP046257.1|WP_035754991.1|3885415_3885871_+|hypothetical-protein
MPEASASVVIKLPADTVWEYCLVPEHVAALTPGVVGIASVSEGPTRVGTTWKGQMRALGRTVEWVGEFTRVDPAQGTEFTSTESPFGFTISATFDDARDGVRLTYRVHNDGVGGGAIGRIADALAIRAFQRSLAASARRLPRLVDEWAARR
>NZ_CP046257.1|WP_035754993.1|3884351_3885209_-|ParA-family-protein
MAKVIATISLKGGVGKTTVTAGLAEYMSAEFGQRVLLIDLDSQINLTTMMISEERWLELNTNGRTLATLFSDAVKGTRYFRLDEAVERGVSPVKKVNSVDLLASSLDLIEVQEDLSALRVEGRVPNGGTGFLREAIEPVLDFYDYVLIDCPPNIGPITLNGLAAADAYIIPTIPDVLSTYGIPQIQTRVRKIGHEIGRTIVELGVVITKYKANSAVHRSTAMRLRRDPTIQHVLPSYINEANSVAAAAEFTSYGTLRVKYGNQGQFDQFRGLTMDVMTEAQEKIR
>NZ_CP046257.1|WP_006360211.1|3883863_3884355_-|hypothetical-protein
MSSDDTRRRMEYQAVGGALAQLDAKNPQAAQLIAGLVTVIIAEAERSSRFASALTGVVDALRPVDIALDGAPVAAPRKRAAAPKKRVTRQPGAFDPFVVYREGGGQELSARLGELTLDQLRDIIAEQELDTRKETSRKRKPEVLVSWIVERVEASENKGSVFR
>NZ_CP046257.1|WP_006360210.1|3882423_3883833_+|stress-protein
MDNVLTLSAGENRPLPSSAVTVSVRSASPVNTSAILLTDAGRVRSDADLIFYNQPTGPGVGYRSSGAVDIVTVDTAALPRDITTVVVAASLDGTGPSTFATAGALTATLSGGGEELGFTPTGLTSEAAVVCLEIYRRNDTWKVRAVGQGYDAGLAGLVSAFGIDVEDDPAPPPPPGQPPRVTDPQPWPPTNQPVPQPQSPPPAAPPPATPPHPPVTTQPSGVPMHSDLFAPSHAEVSGQGIQKQGSKMCRVGLSGEVMARTGSMVAYQGDLHFEALGSGGLGRMMRQAMTGEGVPLMKVTGRGDLFLANAASDVHLIDLDGTDGLTINGANVLAFDSTLRYDIQRVQGAGAMSNAGLYNCVFTGRGRIAITTDGTPVVLNVDAATYADPQAAVAWSSSLRTSVKSNDSFNLGTLMGRSTGERFTLAFSGQGFVVVQPSELPPGGFIGGTGGGGAAGSGAGGVLGGILGR
>NZ_CP046257.1|WP_035755178.1|3881363_3881963_+|DUF4262-domain-containing-protein
MSDHAAAIRGLPRWHPNPVIRSTIDTIRRCGWQVTSVGEGSPEANSRETDCGFSYTAGLSLHAIPELAIYGVDPLPAHHILNELGDLLHREDWRDLVADQSDIRLQTVAVSVRLIEQVDKDELILANLLFPDYPTLQVVWPDEYGRFPWEEGYILLPMHQPVKGIPDLSAHARRAAHVITTESGPDRTRPRRGRRISGH
>NZ_CP046257.1|WP_035754995.1|3880505_3881231_-|hypothetical-protein
MTKVMVALRAPGPGVELPGADLLGVELLGVELLGAGFRRTCERSGARRVQVHISDDAVTGAMRISELDPPIEAVVSLWDADVDIVLTALGEFATVVGAWRVAERAPLDPDLPADGTRVDALANVAFLRRPAGLDPQEWRRIWLEEHTTVAIETQATFGYYQNVVEDALTPETPQVDGIVEELFPMAAVSDLHAFYGSGGDRAELEHRMTRMLTSVGRFGADRHLDVVPTSRHDLVLEVPAR
>NZ_CP046257.1|WP_006360199.1|3879852_3880251_-|30S-ribosomal-protein-S8
MTMTDPIADFLTRLRNANSAYHDEVKLPSSKIKVNIAEILKREGYITDYRIEDAEVGKSLIVSLKYGPSRERSIAGLRRVSKPGLRIYAKSTNLPKVLGGLGVAIISTSSGLLTDRQAANQGVGGEVLAYVW
>NZ_CP046257.1|WP_006360198.1|3879302_3879839_-|50S-ribosomal-protein-L6
MSRIGKNPIEIPAGVDVTVDGQRVAVKGPKGELSLTVSEPIEVAKEDNTIVVTRPNDERRSRALHGLSRSLINNLVIGVTQGYTTKMEIFGVGYRVQAKGKDLEFALGYSHPVPIEAPEGITFAVESPTKFSVTGIDKQQVGQISANIRRLRRPDPYKGKGIRYEGEQIRRKVGKTGK
>NZ_CP046257.1|WP_006360197.1|3878894_3879299_-|50S-ribosomal-protein-L18
MSDTATKTSRKPLGKDVSTRRRKATVNRHFRLRKKVSGTPARPRLAVKRSSRHIHVQLIDDLAGKTLAAASSIEADVRAAGGDKSAQARKVGELIAARAKAAGVEAVVFDRGGKDYHGRIAALADAAREGGLSF
>NZ_CP046257.1|WP_005197623.1|3878200_3878848_-|30S-ribosomal-protein-S5
MPGRQRDGGNGPAGNDNNQNNAGGGNDRRGGGRGDRRDRGGRDQDRNQLERVVTINRVSKVVKGGRRFSFTALVVVGDGQGMVGVGYGKAKEVPAAIQKGVEEARKNFFRVPLIGGTVTHPVQGEAAAGVVMLRPASPGTGVIAGGAVRAVLECAGVHDVLAKSLGSDNAINVVHATVAALKMLQRPEEVAARRGLPIEDVAPAGMLRARAGQGV
>NZ_CP046257.1|WP_005197641.1|3890021_3890207_-|type-Z-30S-ribosomal-protein-S14
MAKKALVNKANKKPKFAVRGYTRCNKCGRPHSVFRKFGLCRICLREMAHAGELPGVQKSSW
>NZ_CP046257.1|WP_035754990.1|3890208_3890811_-|50S-ribosomal-protein-L5
MTSTEIENGSAGTKIQPRLKTRYREEIKGQLNEQFEYPNVMLIPGVVKVVVNMGVGDAARDAKLINGAVEDLAKITGQRPEIRRARKSIAQFKLREGMPIGARATLRGDRMWEFLDRLVSIALPRIRDFRGLSDQQFDGNGNYTFGLNEQSMFHEINIDNIDRPRGMDITVVTSARTDEEGRALLRALGFPFKDNNVKDN
>NZ_CP046257.1|WP_005197643.1|3890812_3891130_-|50S-ribosomal-protein-L24
MKVHKGDTVIVISGKDKGAKGKVIQAFPKTQRVLVEGVNRIKKHTAASANERGASSGGIVTQEASIHVSNVMVVDSDGNPTRVGYRVDEETGKKVRISRKSGKDI
>NZ_CP046257.1|WP_005197644.1|3891132_3891501_-|50S-ribosomal-protein-L14
MIQQESRLRVADNTGAKEILCIRVLGGSSRRYAGIGDVIVATVKDAIPGGNVKKGEVVKAVIVRTTKERRRPDGSYIRFDENAAVILKGESDPRGTRIFGPVGRELREKKFMKIVSLAPEVI
>NZ_CP046257.1|WP_155225486.1|3892073_3905867_+|amino-acid-adenylation-domain-containing-protein
MTTEDTIRHTSRIESTSDRDPAIPMTAAQRGIFYAQQLEPDVPLTIDAYIEFRGDTSGSDGAPVDIDPEILQRATTLTELETEASMLRLTPTDDAEPTLTIDRSRRLVLGTQDFSDAADPRAAALAWIDDHRSKSPDMFSDPLLDTHLLKIGSGHSIWYCRGHHIGYDGYAAMYLMLRVSSHYTAIVNNAPPPLADTATMAEIAAMDVAYRASEKFLDDREYWSQHLADLPELATLTRRSGPAAPLSTVRSAVLDDDLVTRIRSLARAHRVRPASVITAAVAAYVARFTDRDEAVLSLPVAARDRDVLRTSAGLVSNVVPLRVALDHDATVADLLASVNAEIKSAVRHQKYRHEDIVADILDAAGARRGFFGPLVNVMLFFQHIDFGPVHGELNVLSTGPIEDLSVNVYDSLDGGMSVDLEANPNIYSDDEIVTHHRRLVEFLEALVTATSETPVSHVSVLRECEYAELSQHSTGARVELGERTLVDLLDEAAAAHPDAPALIAAHPRDSTESRPLSQAEFARQARSLAAALQDRGIGAESIVAVRLRRSVDQVLALHAVVRAGAAFVPVDPDEPADRLEHILTVAAPDLVLTDANLAELRANPARREPAPVAGPDNTAYLLFTSGSTGKPKGVAITHRAIVNRLGWMQEWYSLTESDRVLQKTPSTFDVSVWEFFWPFVTGAALVVPSADGHRDPWYLRDVIDEHRITTVHFVPSMLTAFSAALSADSDTPGGAHRRASTTLGSLRQIFTSGEALTPGTVGATAALTSAPIHNLYGPTEAAIDVTHHDACRADVPVVPIGRPVWNTSVHVLDHRLRPQPPGAVGELYLGGVQLARGYRARPDLTAARFVAAPAGSGERLYRTGDLVRMNADGELEYLGRTDSQVKIRGQRVELGEIESTLGSLHGVASAGVVVRDDLVVDGPVLVGYVSGTADLHTRELRSELESALPAHMIPTAIMVLDVLPTTSNGKLDRRALPRPELRTDREFVAPETALDRFVVRTVADVLGLDPDSTESAPISLRDDFFAIGGTSLSATRVASRLSKATGRRIGIRTIFDAADIGGIVDALAELGVGADDSPQSTSARTGSPVLAGSPVPLSPAQHRLWLATRLDPAGAATYNMPFTVRLVGTLDTDALRQALNDVIVRHEPLRSIVVERDGIAFMSPRSPETVSVDLPVLRTPDVRDLPDREFASQTFDLGVDLPIRARLVRTSDDDHRLTMVVNHIAADGWSLAPLAGDLATAYRARRDGNEPDWAALPVTYSQVSADRHAWLSESSGATAELEFWRATLADAPGETDLPLDRPRTGRGDASGASVTHTLSPDTHRAIRDLSAATGATVFMVLHAAVATLLRSLSRSSDVIVGTPVAGRGDADLDGLVGMFVNTLALRTAVDKDAAFVDLLAHVRDVDLNAFDNADLPFDRLVTELNPDRSSHVHPFFQVSLALEDRSAIRLDFAGLSATASRVDTGYTTFDLQLTFTEAQDSDGEPAGLSLEIGYATALFDRSTVTALSSRLDRLLQAATAQPSSAVGDLPVLDLHERLDLVPAVGEGRRPVEHLTTLLSTAAASSPYRIAITDGTRSLTYRDLDAASNRLARLLIERGAGPERHVAVALPRGVDWMIAMWAVARSGAAWVPVDPAYPAARIAHMLGDSGACLLLTDRSADPRTALADESASNPGHLPQTLVLDDDEVIESVRRMSAAPVSSGERPGPLDVDQPAYLIYTSGTTGTPKGVVVSHRGLADFAAQQVTQYGITPDSQTMHMASPSFDASVLEILMAIAAGSTMHIIPPGIVGGAELAELMREGHVTHAFLTPSVLTTMSPDDVPELEALVIGGEHPNPEVVRTWSSGPRLFNAYGPTETTVVAAVSSPIEPDYRTLTIGRPIRGVSALVLDERLQPVAPGAVGELYIAGEHLARGYHGVRPLTSKRFIANPFGDPGERMYRTGDLVRWTTDHELEFRGRADHQTKVRGHRIELGEIDAVLVADAAVRAAVTTTHGEGDRAHLVSYVTMADGTGDTASDVRDRLSDRLPRHMIPSTIVELDEIPTTPIGKVDLRALPAPEALPVETGVAYVAPLTPTEQTVADLIAERLDLEPNTVGRHHDFFDLGGNSLLATQIVGALEHLTGHRIPVREVFDHSTVAAIARLVPARDLERPDTNVTRIPRLVHDPDAPVEPGPAQQQLWFLNQLAVGEAADGDGSATAGYAIAFALDLRGHLDVEALAAAIRHTVDRHVMLRTVYPDLDGRPVLEVHPAGAATLDLAVTDITEAHWPEMARALAARPFDLTTDLPLRTALHRIDGDAMHHRLSIVIHHIAADGWSMIPLHRDITHTYAELRDGTTTGARPMTDTAIDYLDYLRWQAENLADHGELTDWWRRELDGIDAGPILIPDAPAGRPRRAEVVEVEFGAEIRRRLMAVSPDHATEFMSVHALFAALLHRLHADPATHVGGASSDIIIGTPVAGRNDPRLADVVGMFVNSVVLRTPVDGRESFTTLLDSVRRRDLEALSQSDMPFERIVSMVNPPRDGRHPIFQIALAFDAQTTDASTDRAPSGPLAAGSGISDLRIDADEIDTGVARFDLELRIRDGRARFTYATDVHTRARVEILARMFAELADAATAHPDVPLDDLHLTTTADRQPVGEPTVTPRHLADIITATARRYPDQVAVEDSDRSLTYAEIDEISTIWAHNLQAFEVGTDDVVAVALERSIESVIATWAVAKSGAAILPVDTRYPADRVAHMISDSGARLGITSADRFADVPQEIWWASPGILGVPWESPTPGADSLAGPRHTDSLAYVVYTSGSTGKPKGVSVTHRGLAAFGAAQRDRYRVAPGDRTLHFASPAFDAAMLEFLLAFEVGATMVIVPSTIYGGDELVDFVDEHAVTHAFITPAALATAAPHPLPLLRTLGVGGEASTPELVARWGADRSYINSYGPTETTIVAVMSRPLRPGAPITIGTPVTDCTALVLDHRLRPVPDHVPGELYLSGPGVARGYLDRRGPTSARFVARPDGSGDVMYRTGDIVRRDADGSLIYHGRSDNQVKVRGFRIELDEVTAALNAAEGVDFATTIVRGQGADAVLVGYVTVTDPTGAPDTAAILDTVRQRLPRHMVPSAVVVLDSIPLTRNGKLDHCALPAPATTVVSTSGRAPRTLAETALTHILADVLDLRPDEVGATDDFFLLGGTSLQATTLVSRINRVHIGERLRVRDVFDHPTPEALAQLLVLPQGWDASAPDAADVISGSVEDAAPIRRSDRPERFPLAPTQRRLHSMATANPESTEYLMPFVLHLRGELDVPALRGALVDIVARHTSLRTIFESDEHGPMGRVLDDPEAVIGDLTVQWTTDVAAEITRSATRPMDLTRRAPITATLVADSSTTGSETEHVLVLVLHHIAADGASLPILVADLTRAYGERRRGRTENWPPADVDYRDHAVESADAESLAHDLRFWEETLADAPAETTVAPLTDDAQPSESGAGSVSLGLPAHTRAGLVAFAREQSTTPFSVLHTALAILLHRLGLGTDLVVGSPVANRIGHDADHDYSGVVGMFVNVVPLRTRLAAADTVAGLVRRIRDADVDALDHRGLPFDDIVASLNPPRTPGRHPLFQVALSVHDYTAGNTGVPADGLPAATIEMDAGLRASIAEFDSPEAKFDLQFTITGIRDGDAALQVTYDTARYRRQDAELLATRLMRVVRGMLGDPGRPIGDIRITDPLEIAERTPSLGRPAQMPTTLDRLFAQAVQRNPDGVAAMAGSPESPETITYAELDARSNRLARVLLGRGVGAADAEHVVAMAVQRSIESLVAIWAIVKTGAAYVPIDPTYPADRIAHMLGDSGARLVVTTAAAGESIAAGMAGDPTPLLVLDDASTMTRLQHSSPSPITDSERGSTIRPDQLAYIIYTSGSTGRPKGVLVPHSGLRPVHDELAHRMAPGPMSRVLHFASPSFDASVLEMLLALAGSAPLVIVGPQVYGGEALSDVIDSAQVTHAFITPAAVASMSPAAVPSLRALAVGGEDYGADLVRRWAPGRTLINVYGPTETTIIITGSESLTPNRQLTIGTPNNGVGALVLDERLHPVPAGVVGELYLMGPQITRGYHRRPGLTSTRFVPAPMVTGPRFAGRRMYRTGDLVRWTEDGRLVYVGRGDTQVQVRGFRIELGEIDDALTTEPDVDFAVTLVDGTGAAAKLRSYVTATDGAAPDPADLRRRVSRRLPRHMVPTSVTLLDSIPLTPTGKLDRKALPASTDDATRRAPAPGEETTIAQVFAEVLEVAPDTIGADDGFFDLGGNSLLATAVTARLTERTGRQVSAQSLFGAPSPAELAAALGIDGAAPTDPSEQSGTAGLDMLLPLRRQRGDTTGNPGEPPLFVVHPAIGLSWSFTSLLPHLPAGRALYGLQHPALSGKRCPRSIGDLAADYVAQIRTVAPEGPYHLVGWSLGGLIAHEMAVQLREAGDEVARLVVLDSYVISERPDLDAEASITDLMREFGLDLDSEELSGTDELTVADAHRIISSVGGALGGLARDTLGTVHEVFRHASPLAEKWRPRVYDGDLSFVTATVDPQPGAPAVEAWYSKVTGRVVEIESHSTHARMMLPEHVSDWVHAIGVSPGEPASATRQEK
>NZ_CP046257.1|WP_005197647.1|3905866_3906124_+|MbtH-family-protein
MTNPFDDTDGVFRVLVNHENQHSLWPEFAPVPDGWRTVFGPSGHDECLEYVEQNWRDMRPASLIRTMESAQDEGSEVTRGATQYR
>NZ_CP046257.1|WP_155225487.1|3906101_3907328_+|ATP-binding-cassette-domain-containing-protein
MGRHSIADDTPDRGASPYALELRGLQKTFRTGLFGRGPRVHALNGLDLSVPTGTVHALLGPNGAGKTTTVRAVATLMTPDEGSVIVDGIDAIADPGAVRKIVGVSGQYAAVDGNLTGFENLRMVGQLYGQPRALASERARELIAELNLEDAADRPMRTYSGGMRRRLDLAGALINRPSLVILDEPTTGLDPRGRRQMWEVIAEQVSSGATVLLTTQYLEEADALADEITVIDHGTIRAQGSAAELKSATGGSILTVEVVVPHTDDADARVSASLTDIGVGPAERLESGADGDIGIDSVRWSVPVDDGTRSAVAAVRALSTAGIVVVDASVSTPTLDDVFLTLTDRGHTEPPTVDQITDAPTDSYLTVAEPDIDGKAVDGLAGPVIGTDDTDADVTDIPPSRSERARVH
>NZ_CP046257.1|WP_035754986.1|3907317_3908100_+|ABC-transporter-permease
MFTDTAVLVERNLLTVKRIPTLLISATIQPLMFVFLFAYVFGATFGGSSYREFLMAGIFTQTVVFNAAFTTVGLANDTSDGIIDRLRSLPMTRLGVISGRVTSDMLLGAVGLAVMVACGLAIGWRIYGSAADAAIAFGIIGLFAIAMAWVGAVSGLAAPNVEAAQSIGFLWMFPVTFLSSAFISAQSLPGPLRTIAEWNPVTAVATACRQLFGNEAPPMFPTATGWVADHAVGYAVGSSLVILAVCVPVSLALYRRSANR
>NZ_CP046257.1|WP_155225488.1|3908147_3908756_+|sigma-70-family-RNA-polymerase-sigma-factor
MTSDDGSATPDADHGRGHESRLLRDLLESASTGDRAAFTRLYDLTSSRIYGLAFRVVRDREYAEEIVQEAYLQYWQKAGQYHAARGSVLTWMMTIAHRRAVDRVRTEQLQQERMSDYGAASVETPRNIPLEVVVHADEARTLRTCLGELTELQRSSIEMSYFGGLTYPEVAEQTKTPLPTIKSRIRDGLRRLKQCLGTQEDV
>NZ_CP046257.1|WP_035754977.1|3908748_3909573_+|anti-sigma-factor
MSELTMTTTDTDPDDRMSAWLDDHIELYAVSALTPEETLRAERELAALPPDARSAYEDRIVEIHTAMAGFSSTYALETPSGLRGRVLTHVFDGAAGFDAPTPPPIPEPVPIGGRRQGPQRTTAVLAAAAVTVVVALGAGVLIGRTTAPEPSPAATSVGETQQEVLTVLAAGDATITAEPLADDRGTITVITSETAGRAVTLIRDPGRPISPDSTFQLWLVGGAEKPVPAGLIPGGDTEPVVVDGLGDAQVLAVTIEPAGGSPQPTTPILAQVRL

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Crispr_ID: NZ_CP046257_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046257_7

4761543-4761679

Orphan

Consensus_repeat	Method
GCCTTCTTGGCGGGCGCCTTCTTCGC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP046257_7

>merge|NZ_CP046257|7|4761543-4761679|CRISPRCasFinder
GCCTTCTTGGCGGGCGCCTTCTTCGCCGTGCTCTTGCTGCCCGACGATCCAGAGCTGCTCTTCGACGCCGCCTTCTTGGCCGGCGCCTTCTTCGCGGGCGCCTTCTTGGCGGCCTTCTTCGCCGGAGCCTTCGCGGC

>NZ_CP046257|7|6|4761543-4761679|CRISPRCasFinder
GCCTTCTTGGCGGGCGCCTTCTTCGC	CGTGCTCTTGCTGCCCGACGATCCAGAGCTGCTCTTCGACGCC
GCCTTCTTGGCCGGCGCCTTCTTCGC	GGGCGCCTTCTTGGCG
GCCTTCTTCGCCGGAGCCTTCGCGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046257.1\|WP_155225632.1\|4766584_4767358_+\|prolyl-oligopeptidase-family-serine-peptidase	unknown	unknown	gnl\|CDD\|223489
NZ_CP046257.1\|WP_035753701.1\|4769932_4770349_-\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|211538
NZ_CP046257.1\|WP_035753710.1\|4758506_4759127_-\|amino-acid-transporter	unknown	unknown	gnl\|CDD\|224198
NZ_CP046257.1\|WP_006358001.1\|4770475_4770952_-\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_CP046257.1\|WP_006357988.1\|4756838_4757504_-\|CDP-alcohol-phosphatidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|223632
NZ_CP046257.1\|WP_006357986.1\|4755085_4755700_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP046257.1\|WP_006357991.1\|4759212_4760121_+\|LysR-family-transcriptional-regulator-ArgP	unknown	unknown	gnl\|CDD\|235144
NZ_CP046257.1\|WP_006357999.1\|4769413_4769839_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|379266
NZ_CP046257.1\|WP_006357989.1\|4757556_4758438_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377085
NZ_CP046257.1\|WP_006357992.1\|4760134_4761463_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|162098
NZ_CP046257.1\|WP_006357997.1\|4767524_4768262_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277347
NZ_CP046257.1\|WP_006357998.1\|4768279_4769308_-\|YdcF-family-protein	unknown	unknown	gnl\|CDD\|99750
NZ_CP046257.1\|WP_006357983.1\|4751813_4753403_-\|phytoene-desaturase	unknown	unknown	gnl\|CDD\|274273
NZ_CP046257.1\|WP_006357985.1\|4754348_4754933_-\|isopentenyl-diphosphate-Delta-isomerase	unknown	unknown	gnl\|CDD\|235156
NZ_CP046257.1\|WP_006357984.1\|4753399_4754311_-\|phytoene-synthase	unknown	unknown	gnl\|CDD\|173831
NZ_CP046257.1\|WP_006358003.1\|4775125_4776658_-\|NAD(P)(+)-transhydrogenase-(Re/Si-specific)-subunit-beta	unknown	unknown	gnl\|CDD\|376743
NZ_CP046257.1\|WP_006357995.1\|4765014_4766535_+\|multidrug-efflux-MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP046257.1\|WP_006358292.1\|4772883_4774191_+\|ISL3-family-transposase	unknown	unknown	gnl\|CDD\|376574
NZ_CP046257.1\|WP_155225631.1\|4762618_4765015_+\|ATP-dependent-DNA-ligase	unknown	unknown	gnl\|CDD\|236599
NZ_CP046257.1\|WP_006357987.1\|4755793_4756816_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378925

Protein	Function_ID	Function_description	E-value
NZ_CP046257.1\|WP_155225632.1\|4766584_4767358_+\|prolyl-oligopeptidase-family-serine-peptidase	gnl\|CDD\|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	5.02382e-36
NZ_CP046257.1\|WP_035753701.1\|4769932_4770349_-\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	gnl\|CDD\|211538	TIGR00026, Hypothetical_protein_Rv1261c/MT1299/Mb1292c., deazaflavin-dependent oxidoreductase, nitroreductase family. This model represents a family of proteins found in paralogous families in the genera Mycobacterium and Streptomyces. Seven members are in Mycobacterium tuberculosis. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. [Unknown function, Enzymes of unknown specificity].	2.20632e-23
NZ_CP046257.1\|WP_035753710.1\|4758506_4759127_-\|amino-acid-transporter	gnl\|CDD\|224198	COG1279, COG1279, Lysine efflux permease [General function prediction only].	3.98364e-56
NZ_CP046257.1\|WP_006358001.1\|4770475_4770952_-\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	2.53481e-28
NZ_CP046257.1\|WP_006357988.1\|4756838_4757504_-\|CDP-alcohol-phosphatidyltransferase-family-protein	gnl\|CDD\|223632	COG0558, PgsA, Phosphatidylglycerophosphate synthase [Lipid metabolism].	9.02832e-13
NZ_CP046257.1\|WP_006357986.1\|4755085_4755700_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.18737e-15
NZ_CP046257.1\|WP_006357991.1\|4759212_4760121_+\|LysR-family-transcriptional-regulator-ArgP	gnl\|CDD\|235144	PRK03635, PRK03635, ArgP/LysG family DNA-binding transcriptional regulator.	4.0995e-120
NZ_CP046257.1\|WP_006357999.1\|4769413_4769839_-\|DoxX-family-protein	gnl\|CDD\|379266	pfam13564, DoxX_2, DoxX-like family. This family of uncharacterized proteins are related to DoxX pfam07681.	1.45381e-10
NZ_CP046257.1\|WP_006357989.1\|4757556_4758438_-\|hypothetical-protein	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	5.86072e-14
NZ_CP046257.1\|WP_006357992.1\|4760134_4761463_-\|MFS-transporter	gnl\|CDD\|162098	TIGR00900, multidrug_transporter, H+ Antiporter protein. [Transport and binding proteins, Cations and iron carrying compounds].	2.13214e-51
NZ_CP046257.1\|WP_006357997.1\|4767524_4768262_+\|metallophosphoesterase	gnl\|CDD\|277347	cd07402, MPP_GpdQ, Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain. GpdQ (glycerophosphodiesterase Q, also known as Rv0805 in Mycobacterium tuberculosis) is a binuclear metallophosphoesterase from Enterobacter aerogenes that catalyzes the hydrolysis of mono-, di-, and triester substrates, including some organophosphate pesticides and products of the degradation of nerve agents. The GpdQ homolog, Rv0805, has 2',3'-cyclic nucleotide phosphodiesterase activity. GpdQ and Rv0805 belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.17088e-49
NZ_CP046257.1\|WP_006357998.1\|4768279_4769308_-\|YdcF-family-protein	gnl\|CDD\|99750	cd06259, YdcF-like, YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been idenitified. The family also includes Escherichia coli sanA and Salmonella typhimurium sfiX, which are involved in vancomycin resistance; sfiX may also be involved in murein synthesis.	7.56627e-29
NZ_CP046257.1\|WP_006357983.1\|4751813_4753403_-\|phytoene-desaturase	gnl\|CDD\|274273	TIGR02734, Phytoene_desaturase_lycopene-forming, phytoene desaturase. Phytoene is converted to lycopene by desaturation at four (two symmetrical pairs of) sites. This is achieved by two enzymes (crtP and crtQ) in cyanobacteria (Gloeobacter being an exception) and plants, but by a single enzyme in most other bacteria and in fungi. This single enzyme is called the bacterial-type phytoene desaturase, or CrtI. Most members of this family, part of the larger pfam01593, which also contains amino oxidases, are CrtI itself; it is likely that all members act on either phytoene or on related compounds such as dehydrosqualene, for carotenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	3.32239e-180
NZ_CP046257.1\|WP_006357985.1\|4754348_4754933_-\|isopentenyl-diphosphate-Delta-isomerase	gnl\|CDD\|235156	PRK03759, PRK03759, isopentenyl-diphosphate Delta-isomerase.	8.04707e-88
NZ_CP046257.1\|WP_006357984.1\|4753399_4754311_-\|phytoene-synthase	gnl\|CDD\|173831	cd00683, Trans_IPPS_HH, Trans-Isoprenyl Diphosphate Synthases, head-to-head. These trans-Isoprenyl Diphosphate Synthases (Trans_IPPS) catalyze a head-to-head (HH) (1'-1) condensation reaction. This CD includes squalene and phytoene synthases which catalyze the 1'-1 condensation of two 15-carbon (farnesyl) and 20-carbon (geranylgeranyl) isoprenyl diphosphates, respectively. The catalytic site consists of a large central cavity formed by mostly antiparallel alpha helices with two aspartate-rich regions (DXXXD) located on opposite walls. These residues mediate binding of prenyl phosphates. A two-step reaction has been proposed for squalene synthase (farnesyl-diphosphate farnesyltransferase) in which, two molecules of FPP react to form a stable cyclopropylcarbinyl diphosphate intermediate, and then the intermediate undergoes heterolysis, isomerization, and reduction with NADPH to form squalene, a precursor of cholestrol. The carotenoid biosynthesis enzyme, phytoene synthase (CrtB), catalyzes the condensation reaction of two molecules of geranylgeranyl diphosphate to produce phytoene, a precursor of beta-carotene. These enzymes produce the triterpene and tetraterpene precursors for many diverse sterol and carotenoid end products and are widely distributed among eukareya, bacteria, and archaea.	9.16083e-46
NZ_CP046257.1\|WP_006358003.1\|4775125_4776658_-\|NAD(P)(+)-transhydrogenase-(Re/Si-specific)-subunit-beta	gnl\|CDD\|376743	pfam02233, PNTB, NAD(P) transhydrogenase beta subunit. This family corresponds to the beta subunit of NADP transhydrogenase in prokaryotes, and either the protein N- or C terminal in eukaryotes. The domain is often found in conjunction with pfam01262. Pyridine nucleotide transhydrogenase catalyzes the reduction of NAD+ to NADPH. A complete loss of activity occurs upon mutation of Gly314 in E. coli.	0
NZ_CP046257.1\|WP_006357995.1\|4765014_4766535_+\|multidrug-efflux-MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.5122e-100
NZ_CP046257.1\|WP_006358292.1\|4772883_4774191_+\|ISL3-family-transposase	gnl\|CDD\|376574	pfam01610, DDE_Tnp_ISL3, Transposase. Transposase proteins are necessary for efficient DNA transposition. Contains transposases for IS204, IS1001, IS1096 and IS1165.	2.45914e-76
NZ_CP046257.1\|WP_155225631.1\|4762618_4765015_+\|ATP-dependent-DNA-ligase	gnl\|CDD\|236599	PRK09632, PRK09632, ATP-dependent DNA ligase; Reviewed.	0
NZ_CP046257.1\|WP_006357987.1\|4755793_4756816_+\|hypothetical-protein	gnl\|CDD\|378925	pfam12698, ABC2_membrane_3, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	0.000180684

>NZ_CP046257.1|WP_006357992.1|4760134_4761463_-|MFS-transporter
MSTNVDIRLPRALKPLARRQYRLLASGLILAMFGDGIWTIAVIWQVIALSGGPGQVSLAAGTAAVGMLVSTLVGGVLADRISQRHIMIGLEVTKMAAFGAVGAASVFGVLDLWMVVMASLLAGVTMGMYYPAYSALLPGVVSASELQAANGIEGFFRPVVFQAVGPMVAGAVIGATAPGQAVVLAAIASIASGGCYLVMTPVTSRRLGEPETSEAEVARTSARGSVVVDLVEGFVYMIRTPWLWGTLFFACVLVLATMGPIEVLVPFALRERIDGGASQHAWVLAGFGIGAAATSLVFASLPMPRRYLTVMFGIWSFSSVPLVLMGVADATWMFVAAGVGMGVMFDGPMVLWGTLLQRRVPPALLGRIASLDFFVSVALMPVSMAIAAPVSSAIGLTATFVLAGLLPVPIAWAFYFAARMWRDEIENPLVDETPPTLVSVND
>NZ_CP046257.1|WP_006357991.1|4759212_4760121_+|LysR-family-transcriptional-regulator-ArgP
MDISQEGLRTLAAVLREGTFDAAASSLHITPSAVSQRIKALESAVGRVVLRRTKPASATPDGEVLVRLARQWELLLAETRAEFVGEPDDDDAPVTSRPRVHLPIATNADSLATWLLPVLARFHREHAVAVEVFRDDETRSSALLKSGDALAAVTSDPIAIRGCALQSLGSMRYLPVATPEFIATWLSDGLDAEALARAPMVQFDRNDHIQLDMVAALAGRAVDPPAAYIPSSTEYHRAVSLGIGWGAVPVVQIREPLDDGRVRLIADHHLDVPLYWQHWKLSSPLLQHLTDLVVTGAAEVLR
>NZ_CP046257.1|WP_035753710.1|4758506_4759127_-|amino-acid-transporter
MSSYLLPAIAGLLTGAGLIVAIGPQNVFVLRQGVARRHTGAIVAVCAISDVVLIVAGVAGLGAIVAAHPQVITVAKLLGGLYVLVLGLLAAKRCLRSNEAIAANAEEAESAGRWVAVGTALALTWLNPHVYLDTVLTMGAIANGHGNGKWAFAIGACVASILWFTALGGGARRLSHLFASPRAWKILDAVVAVIMIGMAVALFASI
>NZ_CP046257.1|WP_006357989.1|4757556_4758438_-|hypothetical-protein
MILSSAAPQARSAPGTVLSAVRRLASGTKEVLARGDLAAAAATLTYYAAIAVVPWVLLAIWSTTWLRGDAAAESTWRELAVLIPPEMGGRDVFGEAVSVGTSLTGWGALVLLFPASFYGEGLRRACLMMHPEKDRFTGWRSRLSILVLFVFVPPLTAVAVAVASSITTLAPDGGGTGDLGDLAARVVIEFLVVWLTLTIPLTWVYWKVTPGGPSLFVSAVTALGAASFIAGFSQGFLLFLSLPIDVGIPYGGLRVIGGVVAAGLWLYVLHILVIVGWAVGQSLGRTAGGGRVD
>NZ_CP046257.1|WP_006357988.1|4756838_4757504_-|CDP-alcohol-phosphatidyltransferase-family-protein
MLDAWSELHGGIDPRGSFWVERWVLLSNACARPLVRLGITPNVITVCGAAVTAIAFAVTFAGRGWFAVAAVVILLAAVLDGVDGAIAAQTGAATQWGRVLDTMADRWSDIFLAGIVVMAGAPPWSGVVIAVLTLFLEGTRATAQAAGMKGPGTVTVWERPSRVILAFIAMVVATVVWQVGLADGVARTLAAIIAGIGATLATIGLLQLFVAVFRQTRGLRA
>NZ_CP046257.1|WP_006357987.1|4755793_4756816_+|hypothetical-protein
MTTYTEPSDRNLATEDRPPEPSRSHGPSWRIVVALVFAIPIVVSTIAAMFVSLAVDPEPHDVPLGLVAPAPAAQAIESVLADRAGEDAFAVEQFADPAAAREAIESRDIVGAITVGPQGVTALTAEAGSPALAQIVTGVGASIATAQSLPVTTESVVAPPATDARGTGFAAGLLPLLIAGIALGAAAAIALAGRVWMQATVVLVGPLVAGLGFAAVWSWLGVIDGRVVPVALALTLMIGAISWFTAGAGSLIGAPGVGIAAILMMLISNPLSGLASSPYLLPAPWGALGQWLPTGAGGTLTRSVAYFPDASFAGPLWILLGWIAVGAILLAVSGLRPRRG
>NZ_CP046257.1|WP_006357986.1|4755085_4755700_-|TetR/AcrR-family-transcriptional-regulator
MPKISAERKLERSQQILDAARRCFAEKGFHRASMSDVIRESGLSAGAVYSYYSSKEQLIAAVARSVFLAYESGLGDLVGGDGAPASPEDAIRMLAARVMAEIAPLTDDFRMVMTIWGEAANNPELREIVREIILGLRKVFEHVLVRWRDSGHELPGEPAELALPMVSVMQGVVVQQSLVGDVDLDAYVDTWCALMRAAGLGDQG
>NZ_CP046257.1|WP_006357985.1|4754348_4754933_-|isopentenyl-diphosphate-Delta-isomerase
MTNDSVVLADADGRPCGTADREGVHGLDTPLHFAFSCHLVDADNRILMTRRALSKRSWPGVWTNSFCGHPRPGEAVVDAVHRYAQRELGIDVDDVRCILPDFRYRAVDASGIVENEICPVYVARPVGSLKPSPDEVAEYAWAEVPDVWDLALRTPWAVSPWFADQVRQLPGPDPYGIVDAADATHPIIARASNS
>NZ_CP046257.1|WP_006357984.1|4753399_4754311_-|phytoene-synthase
MMHLPGHTELVPPHRRYDAVAEASAALVIRSYSSSFGLASRLLAPAIRRDVRNIYALVRVADEIVDAPRPEQGLVDRSNELDQLEDQTSAAMITGSSSNLVVHAFARTARRVGIDLDLVAPFFASMRSDLTEVEHDFESLASYIYGSAEVVGLMCLRAFLAEEAKAEARYDHLAPGARRLGAAFQKINFLRDFGEDSDGLGRRYLVGLDPDSPDDAAWSLWLDDIDLDLTAAAAAIPHLPASSRVAVCTAHDLFAELTARLRESSAAEARLNRVRVPNAGKARIAAAAVARRGMPRTARGVDA
>NZ_CP046257.1|WP_006357983.1|4751813_4753403_-|phytoene-desaturase
MTARKRIAVIGGGVAGLSTAALLAHDGHDVEVIEKNDDLGGRAGLWSKDGFRFDTGPSWWLMPEVFDHYFEMLGTSTKEQLDLVRLDPGYRVFFGENGSDEPPLDIFGDYERNREVFENIEPGAGAALDSYLQTARQAYDLAVERFLYTSFDSTRAFLSLPVLKNAPTLAKLLTRSLQSFISSKFSDRRLQQVLGYPAVFLGSSPERTPSMYHLMSWMDLADGVRYPQGGFTTLVDALERVARERGVVIHTGTAATSVLTRKRPGRRLRRRAEVVGVRVQTADGGTRDLPADIVVGAADMHHLETKLLPGDLQTFPERYWKRATSGPGAVLAYLGVSGELPELAHHSLYFTEDWKTNFDAIFESPTRVPDPASLYVCKPSATDDSVAPDGHENVFVLVPVPPDPGLGHGGMNGAGDPDIEKVADRAIAMIGQWSGVPDLADRIVVRRTVGPADFVDNVNSWCGGALGPAHTLRQSAFLRSTNRSRKVEGLYYAGSSTRPGIGLPMCLISAELIRKRLNGDRSVGPTPTH
>NZ_CP046257.1|WP_155225631.1|4762618_4765015_+|ATP-dependent-DNA-ligase
MAGGENLEVDGRRISITNLSKVLYPATGTRKYDVIDYYSRIADVMLPHLRNRIVTRKRWPNGVESTPFFEKDMPDSAPDWVRRYGIQHSERVIEYALAEDRATLVWLAQMAALEIHVPQWQLPIGPDGERMANRIVFDLDPGPRVPLHETAAVAVEIRNWLGGTTTYPVTSGGKGIHIYARLPKPVSSEAARKVAREVANEFARQNSDFITANMSKKIRDDKVFIDWSQNNASKTTLSPYSLRGREQPWVAAPRTWDEIEDPKIAQLLYTEVLDRVADVGDLLGGLDAPYDDDPATDADKHGAEEPDAEDSQAGQIINLREYRRKRDESKTPEPFGDENHRQRLRESDEDADTESETGPREPIFVIQEHHARRLHYDFRLEHDGVLVSWAVPKNLPTDPDQNRLAVQTEDHPMDYADFEGDIPAGEYGGGHVSIWDKGTFELEKWREKEVIVRLHGEKVQGRYALIRTGDKNWLAHLMTDEPRPIVPDSLTDPRPMLATDDPIDKLNERDWAFEGKWDGYRLLVRSIGGEFRLTSRSGIDMTKDFPEFAGIADDLGLMDVVLDGEAVAIDSTGRTNFTLFTSRKHTEEQYTLKLHLFDILYLNGTSLLRKPWSVRRELLEELATAFRRSPYVDVPPLLPAPASAAIEYSREHNLEGVVAKRRDSVYQQGRRSTKWLKHKNWSDIEVVVGGYRPGRGNRSHTIGSLLLGLPEETGLRYVGRVGTGFTDAQLRALAEELEPLEISRSPFLDKLDRPIASSAVWVLPKIVGEVRFMDWTTAGHLRHPSWRGIRRDKLPGDL
>NZ_CP046257.1|WP_006357995.1|4765014_4766535_+|multidrug-efflux-MFS-transporter
MSNPAHPQSNKLDRSVIVTGLVIVSGMIMVVLDTTIVNVALESLSTELDASLSTTQWVVTGYLLAVALVIPLTGWAMDRFGPKPTWITAVTLFVAGSALCAAAWSIETLIVFRILQGLGGGMLLPAGQAIITRAAGPDRLGRAMAILGVPMLLGPVLGPVIGGLLVEYTSWHWIFLVNVPVGLVAVALAVWKLPFGDTAPDRDRLDLLGLAVLSGSLVSLLYGLSRASSQGGFGEPDVLGWLVGGAVGLGLYTWHSLRKGTDSIVDVRLLTNRVFAAGTVSVFLVAIGLFGGMLLLPLYYQTVRGEGALNAGLLLAPQGLGAIVAMVIGGRITDRIGAGYVVPVGVVLAMSGTYPFTHVGADSSYLSLSVALFVRGMGLGSVMMPTISAAYSDLSREVVTRAAPTLSAIQQVGASLGSALLVTALTQRLTHELNAHRIPSSGGGTDQIGSVPPEAMPVIGPLLADAFGYAFWVAFALTAVIFVPAMFLPRHRSRDADATPAPPAGI
>NZ_CP046257.1|WP_155225632.1|4766584_4767358_+|prolyl-oligopeptidase-family-serine-peptidase
MTPDVHGETITVPAAFGDTEMYVARPAVSDGRPLPGVLFITDVIGLRPRIRAMADRIASWGYVVAVPHLFYRYGTADEWAPVDDLLLPETLGAFFRAVMPRASTLTFDVARADLIAYLGALRSVPGVSAGPIGVTGYCMGGRLALNLAAARPAEVAAVGIFHTGNLVTDAPDSPHLHLVDIDAFVLAIHADKDRSLPRTAVAQFAHALISSGVTHSASVYPGAAHGYTMSDIPAYHHEAAEHHFAELEALFRRTLTA
>NZ_CP046257.1|WP_006357997.1|4767524_4768262_+|metallophosphoesterase
MFVVAHISDLHFNGTQFNRSRIQSTLSYINARAAGIDVLLVTGDLADEGAPSEYREAYGVLESPLPMLITAGNHDVREPFSATLLGAETSGPINHSRRVGDVLFLMCDSSIPGRNDGYIDDQTLAWMSARLEAEDPQTPVFVAFHHPPVELHMPFMDSIRQTGEERLIPLVERHPNIVAFLCGHAHTPAVTRFADRPLCVAPGVASTLNLPFEGTEIVNRGQPPGIAFHIYDKGRLVTHYRSVVF
>NZ_CP046257.1|WP_006357998.1|4768279_4769308_-|YdcF-family-protein
MTRVKRIRLAAAATIAVAALGGVAVGSLPADGAGVVTVADAVDPAGLYNEAQSKFANGDVAGGLAALQKALTLAPADTDALALQAIWADQMEQASVSNAALSRLRVLNPLLATTARNVISGVATAAQIVPDTTPKPVSGRVAIVVLGFGLNANGKMAPELVNRVSAGKAQSEITTAAPIVVTGGAPKNGITEAAAMKTWLVENGVDTGRILTEDKSGSTVANAQNTSEILRAKGIRDIILVTSPNHIRRGAADFGATGLRVVGTLTTATDLSKYLTPLTKDQTRGIRLEATRAARIPATHQPGALPQNLPDPGPGLLTDLGGQVLKQLLDAGSSAIGSGTEG
>NZ_CP046257.1|WP_006357999.1|4769413_4769839_-|DoxX-family-protein
MATDITTRNSSETTASRNWHRIVGIVISVIVGAFLAFDVVGKLARPQAVIDGTEKLGFDPDQAIVMGVVLLVCLVVYAIPRTAVLGALGITAYLGGAVTANLRIEEPLFSTVLFAVYLGVLMWIGLVLRRPELLKVAGLRR
>NZ_CP046257.1|WP_035753701.1|4769932_4770349_-|nitroreductase-family-deazaflavin-dependent-oxidoreductase
MSIWQWYQRKVNERTVKRIRNKSGTMWGMDMVILRTKGRKSGRQRETPLSWFAHDNGWLVVASGGGKGNPDWYANLAAHPDSVTVERHGGQPVPVTPVVLTGPEREAAWDAVVSAQPRYAKYQKKATREYPLVKLVSA
>NZ_CP046257.1|WP_006358001.1|4770475_4770952_-|Lrp/AsnC-family-transcriptional-regulator
MPSEHRADRIDAKILTALADDPRATVMAVAERTGLSRNTVQARLSKLDAAGALRSFERRVDPAVLGYPLQAYVLTNVTQRKLDQVGAALEAIPEVLQVHGLTGVADLLVHVAAKDADDLYRIAGDILDIKGVKRTTTALVMREMVDFRVRPLLDALAE
>NZ_CP046257.1|WP_006358292.1|4772883_4774191_+|ISL3-family-transposase
MQRSAIADTICRTIELGVTITDAALDGEDRTHLFCEVLAPKSSCPRCERAGRLRDHVDREVADLPIVGHPTRLHLRVPRYACENGACGQGIFRADISAIVAPRAAVTRRTIAWILRRMILDKMSVSAVAASVGLGWNTVNALALQAARTVASAPGRLDGVRVLGVDEHKWKHVRGNGDSSFVTVLVDLTPIVDGTGSARLLDMVGGRSKAALKDWLDARDDSFRDRIRVVTMDGFTGYRTATAEALDKARAVMDPFHVVHLAAEKLTVCRQRVQHDTCGHRGRTGDPLYGIRRPLLTRIALLTDKQKARLRSGLEAHEEHVAVSVTYAIYQELINAYGQENKRDGKIAMYKLLKRIHTGVPSGLAELAQLGRSLWARRAEILAYFDTGASNGPVEAINGRLEHLRGIALGFRNLNHYILRSLIHSGGLAQHLDAL
>NZ_CP046257.1|WP_006358003.1|4775125_4776658_-|NAD(P)(+)-transhydrogenase-(Re/Si-specific)-subunit-beta
MIGSQLVLAAGAHTPSEGLSYLVMALYIVSFSLFIYGLMGLTGPKTAVRGNWIAATGMGLAVAATLLYIYNAGAVGEDGHSTVGVPTINWVLIAIGLVLGVVLGIPPALKTKMTAMPQLVALFNGVGGGTVALIAWAEFIETSGFSVFHNTEPASPLVVGSLIAAIIGSISFWGSLVAFAKLQEIMPKGLEKTFVANAKLFQAANIVLLLVALGLAIYLGVQATDGGGASVWWMVGLLLAAGVMGLFVVFPIGGADMPVVISLLNAMTGLSAAAAGIALDNTALIVAGMIVGASGSILTNLMAKAMNRSIPAIVFGSFGGGDAAVAGGPGAEGGTVKATSAADAAIQMAYANQVIVVPGYGLAVAQAQHAVKEMASLLEAKGVEVKYAIHPVAGRMPGHMNVLLAEADVEYDAMKEMDDINGEFGRTDVAIVIGANDVTNPAARNDPSSPIHGMPILNVDEARSVIVLKRSMSSGYAGIENPLFFADGTSMLFGDAKKSVDSVIEELKAL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	NZ_CP029835	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed5, complete sequence	218298-218322	3	0.88
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	NC_013860	Azospirillum sp. B510 plasmid pAB510f, complete sequence	260657-260681	3	0.88
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	NZ_CP054620	Azospirillum oryzae strain KACC 14407 plasmid unnamed5, complete sequence	46226-46250	3	0.88
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	NZ_CP039640	Azospirillum sp. TSH100 plasmid p1, complete sequence	23569-23593	3	0.88
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	NZ_CP039644	Azospirillum sp. TSA2s plasmid p2, complete sequence	31354-31378	3	0.88
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	1046732-1046756	3	0.88
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	MN908691	Gordonia phage DatBoi, complete genome	79971-79995	3	0.88
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	NZ_CP042557	Acinetobacter baumannii strain E47 plasmid pE47_001, complete sequence	59862-59886	4	0.84
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	MN961671	Pseudomonas aeruginosa strain 201330 plasmid p201330-IMP, complete sequence	56392-56416	4	0.84
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	NZ_MH547561	Pseudomonas aeruginosa strain PA34 plasmid pMKPA34-2, complete sequence	3582-3606	4	0.84
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	NZ_CP022366	Azospirillum sp. TSH58 plasmid TSH58_p04, complete sequence	315446-315470	4	0.84
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	NZ_CP022999	Rhizobium sp. 11515TR strain 10195 plasmid p11515TR-A, complete sequence	1080966-1080990	4	0.84
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	752167-752191	4	0.84
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	NZ_CP032341	Azospirillum brasilense strain MTCC4038 plasmid p2, complete sequence	566942-566966	4	0.84
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	NC_020548	Azoarcus sp. KH32C plasmid pAZKH, complete sequence	735275-735299	4	0.84
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	NZ_CP032348	Azospirillum brasilense strain MTCC4039 plasmid p4, complete sequence	68165-68189	4	0.84
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	NZ_LR134445	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 3, complete sequence	54281-54305	4	0.84
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	NZ_CP052758	Cellulosimicrobium sp. BI34T plasmid pCPRO01, complete sequence	67797-67821	4	0.84
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	NZ_CP007797	Azospirillum brasilense strain Az39 plasmid AbAZ39_p4, complete sequence	599741-599765	4	0.84
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	NZ_CP032695	Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence	1302044-1302068	4	0.84
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	NZ_CP012916	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p2, complete sequence	481671-481695	4	0.84
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	MN204493	Streptomyces phage Zuko, complete genome	9892-9916	4	0.84
NZ_CP046257_6	6.1\|3886416\|24\|NZ_CP046257\|CRT	3886416-3886439	24	NZ_CP011133	Citrobacter amalonaticus Y19 plasmid unnamed, complete sequence	69553-69576	4	0.833
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	NZ_CP029831	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed7, complete sequence	582362-582386	5	0.8
NZ_CP046257_2	2.1\|1131439\|25\|NZ_CP046257\|CRISPRCasFinder	1131439-1131463	25	NZ_CP047177	Rathayibacter sp. VKM Ac-2759 plasmid unnamed1, complete sequence	139478-139502	5	0.8
NZ_CP046257_5	5.1\|3310399\|28\|NZ_CP046257\|CRISPRCasFinder	3310399-3310426	28	NZ_CP017244	Rhizobium etli 8C-3 plasmid pRsp8C3c, complete sequence	249466-249493	6	0.786

1. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to NZ_CP029835 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed5, complete sequence) position: , mismatch: 3, identity: 0.88

agtcgccgacctcgacgttgccctc	CRISPR spacer
cgtcgccgacggcgacgttgccctc	Protospacer
 *********  *************

2. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to NC_013860 (Azospirillum sp. B510 plasmid pAB510f, complete sequence) position: , mismatch: 3, identity: 0.88

agtcgccgacctcgacgttgccctc	CRISPR spacer
cgtcgccgacgacgacgttgccctc	Protospacer
 *********  *************

3. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to NZ_CP054620 (Azospirillum oryzae strain KACC 14407 plasmid unnamed5, complete sequence) position: , mismatch: 3, identity: 0.88

agtcgccgacctcgacgttgccctc	CRISPR spacer
ggtcgccgaccgcgacgttgcccac	Protospacer
.********** *********** *

4. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to NZ_CP039640 (Azospirillum sp. TSH100 plasmid p1, complete sequence) position: , mismatch: 3, identity: 0.88

agtcgccgacctcgacgttgccctc	CRISPR spacer
cgtcgccgacgacgacgttgccctc	Protospacer
 *********  *************

5. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to NZ_CP039644 (Azospirillum sp. TSA2s plasmid p2, complete sequence) position: , mismatch: 3, identity: 0.88

agtcgccgacctcgacgttgccctc	CRISPR spacer
cgtcgccgacgacgacgttgccctc	Protospacer
 *********  *************

6. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 3, identity: 0.88

agtcgccgacctcgacgttgccctc	CRISPR spacer
agcggccgacctcgacgttgtcctc	Protospacer
**. ****************.****

7. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to MN908691 (Gordonia phage DatBoi, complete genome) position: , mismatch: 3, identity: 0.88

agtcgccgacctcgacgttgccctc	CRISPR spacer
attggccggcctcgacgttgccctc	Protospacer
* * ****.****************

8. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to NZ_CP042557 (Acinetobacter baumannii strain E47 plasmid pE47_001, complete sequence) position: , mismatch: 4, identity: 0.84

agtcgccgacctcgacgttgccctc	CRISPR spacer
agtcgccgacctcgacgttcccgcg	Protospacer
******************* ** .

9. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to MN961671 (Pseudomonas aeruginosa strain 201330 plasmid p201330-IMP, complete sequence) position: , mismatch: 4, identity: 0.84

agtcgccgacctcgacgttgccctc	CRISPR spacer
agtcgccgacctcgacgttcccgcg	Protospacer
******************* ** .

10. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to NZ_MH547561 (Pseudomonas aeruginosa strain PA34 plasmid pMKPA34-2, complete sequence) position: , mismatch: 4, identity: 0.84

agtcgccgacctcgacgttgccctc	CRISPR spacer
agtcgccgacctcgacgttcccgcg	Protospacer
******************* ** .

11. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to NZ_CP022366 (Azospirillum sp. TSH58 plasmid TSH58_p04, complete sequence) position: , mismatch: 4, identity: 0.84

agtcgccgacctcgacgttgccctc	CRISPR spacer
cgtagccgaccgcgacgttgccctg	Protospacer
 ** ******* ************

12. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to NZ_CP022999 (Rhizobium sp. 11515TR strain 10195 plasmid p11515TR-A, complete sequence) position: , mismatch: 4, identity: 0.84

agtcgccgacctcgacgttgccctc	CRISPR spacer
gatcgccgacctcgccgctgccctc	Protospacer
..************ **.*******

13. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 4, identity: 0.84

agtcgccgacctcgacgttgccctc	CRISPR spacer
catcgccgacctcgacgtggccttc	Protospacer
 .**************** ***.**

14. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to NZ_CP032341 (Azospirillum brasilense strain MTCC4038 plasmid p2, complete sequence) position: , mismatch: 4, identity: 0.84

agtcgccgacctcgacgttgccctc	CRISPR spacer
cgtagccgaccgcgacgttgccctg	Protospacer
 ** ******* ************

15. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to NC_020548 (Azoarcus sp. KH32C plasmid pAZKH, complete sequence) position: , mismatch: 4, identity: 0.84

agtcgccgacctcgacgttgccctc	CRISPR spacer
ggtcggcgacgtcgacgttgccctg	Protospacer
.**** **** *************

16. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to NZ_CP032348 (Azospirillum brasilense strain MTCC4039 plasmid p4, complete sequence) position: , mismatch: 4, identity: 0.84

agtcgccgacctcgacgttgccctc	CRISPR spacer
cgtagccgaccgcgacgttgccctg	Protospacer
 ** ******* ************

17. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to NZ_LR134445 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 3, complete sequence) position: , mismatch: 4, identity: 0.84

agtcgccgacctcgacgttgccctc	CRISPR spacer
cgtcgccgacctcgacgttccactg	Protospacer
 ****************** * **

18. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to NZ_CP052758 (Cellulosimicrobium sp. BI34T plasmid pCPRO01, complete sequence) position: , mismatch: 4, identity: 0.84

agtcgccgacctcgacgttgccctc	CRISPR spacer
cctcggcgacctcgccgttgccctc	Protospacer
  *** ******** **********

19. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to NZ_CP007797 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p4, complete sequence) position: , mismatch: 4, identity: 0.84

agtcgccgacctcgacgttgccctc	CRISPR spacer
cgtagccgaccgcgacgttgccctg	Protospacer
 ** ******* ************

20. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to NZ_CP032695 (Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence) position: , mismatch: 4, identity: 0.84

agtcgccgacctcgacgttgccctc	CRISPR spacer
gatcgccggcctcgacgttgcccgc	Protospacer
..******.************** *

21. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to NZ_CP012916 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p2, complete sequence) position: , mismatch: 4, identity: 0.84

agtcgccgacctcgacgttgccctc	CRISPR spacer
cgtagccgaccgcgacgttgccctg	Protospacer
 ** ******* ************

22. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to MN204493 (Streptomyces phage Zuko, complete genome) position: , mismatch: 4, identity: 0.84

agtcgccgacctcgacgttgccctc	CRISPR spacer
agtcgccgacctcgaccttggccag	Protospacer
**************** *** **

23. spacer 6.1|3886416|24|NZ_CP046257|CRT matches to NZ_CP011133 (Citrobacter amalonaticus Y19 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.833

gtggtgactccagcgggggtgact	CRISPR spacer
atgatgactccagcgggggtgaag	Protospacer
.**.******************

24. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to NZ_CP029831 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed7, complete sequence) position: , mismatch: 5, identity: 0.8

agtcgccgacctcgacgttgccctc	CRISPR spacer
cctcgccgacgtcgacgttgcccga	Protospacer
  ******** ************

25. spacer 2.1|1131439|25|NZ_CP046257|CRISPRCasFinder matches to NZ_CP047177 (Rathayibacter sp. VKM Ac-2759 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.8

agtcgccgacctcgacgttgccctc	CRISPR spacer
catcgccggcctcgacgttgcccga	Protospacer
 .******.**************

26. spacer 5.1|3310399|28|NZ_CP046257|CRISPRCasFinder matches to NZ_CP017244 (Rhizobium etli 8C-3 plasmid pRsp8C3c, complete sequence) position: , mismatch: 6, identity: 0.786

tggcctagttcggcaccggaccgccgca	CRISPR spacer
tccgccagttcggcatcggaccgccgct	Protospacer
*   *.*********.***********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

25464 : 75963

Leptospira_phage(20.0%)

integrase,protease,transposase

attL 55231:55247|attR 77586:77602

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_035753878.1\|25464_26181_+\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_035753877.1\|26208_26715_-	hypothetical protein	NA	NA	NA	NA
WP_006361193.1\|26832_27123_-	cell division protein CrgA	NA	NA	NA	NA
WP_006361194.1\|27283_27943_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	7.8e-44	46.7
WP_006361195.1\|28016_29966_-	Stk1 family PASTA domain-containing Ser/Thr kinase	A0A1B1IUU3	uncultured_Mediterranean_phage	1.4e-19	30.2
WP_035753874.1\|30035_31400_-	serine/threonine protein kinase	A0A0U2U263	Niemeyer_virus	2.1e-11	24.6
WP_006361197.1\|31396_32896_-	penicillin-binding protein 2	NA	NA	NA	NA
WP_006361198.1\|32892_34326_-	FtsW/RodA/SpoVE family cell cycle protein	NA	NA	NA	NA
WP_006361199.1\|34322_35822_-	serine/threonine-protein phosphatase	NA	NA	NA	NA
WP_005200436.1\|35818_36283_-	FHA domain-containing protein	NA	NA	NA	NA
WP_155224886.1\|36535_37897_-	DUF3662 domain-containing protein	NA	NA	NA	NA
WP_155224887.1\|38488_39838_+	lipase	NA	NA	NA	NA
WP_035754026.1\|43755_44508_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_155225667.1\|44586_45504_-	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_035756060.1\|45508_46579_-	ferredoxin--NADP reductase	Q58M74	Prochlorococcus_phage	2.5e-07	40.9
WP_006361210.1\|46575_47445_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_006361211.1\|47484_49008_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_006361212.1\|49166_50135_-	diiron oxygenase	NA	NA	NA	NA
WP_006361213.1\|50268_50610_+	DUF4873 domain-containing protein	NA	NA	NA	NA
WP_006357955.1\|54011_55655_-	fatty acid--CoA ligase	A0A1V0SBX8	Catovirus	4.8e-18	24.2
55231:55247	attL	NA	NA	NA	NA
WP_035756039.1\|55682_56162_-	hypothetical protein	NA	NA	NA	NA
WP_075863799.1\|56418_57351_-	MCE family protein	NA	NA	NA	NA
WP_035756041.1\|57377_58415_-	MCE family protein	NA	NA	NA	NA
WP_042378896.1\|58414_59461_-	MCE family protein	NA	NA	NA	NA
WP_042378899.1\|59454_60450_-	MCE family protein	NA	NA	NA	NA
WP_155224888.1\|60446_61451_-	MCE family protein	NA	NA	NA	NA
WP_040004233.1\|61451_62486_-	MCE family protein	NA	NA	NA	NA
WP_006359632.1\|62494_63358_-	ABC transporter permease	NA	NA	NA	NA
WP_035756051.1\|63368_64109_-	ABC transporter permease	NA	NA	NA	NA
WP_085950464.1\|64479_65617_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	1.3e-33	35.2
WP_139319570.1\|66046_66901_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_139319571.1\|67465_67732_-	DUF302 domain-containing protein	NA	NA	NA	NA
WP_006358896.1\|67880_68600_-	hypothetical protein	NA	NA	NA	NA
WP_035756068.1\|68865_69282_+	hypothetical protein	NA	NA	NA	NA
WP_155224889.1\|69344_70088_-	DNA replication protein	U5N3V8	Enterobacteria_phage	2.4e-49	42.9
WP_006359312.1\|70480_70807_+\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	9.5e-51	99.0
WP_085948638.1\|70882_72021_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.3e-34	35.6
WP_085948641.1\|72766_73931_+\|transposase	IS3 family transposase	U5P429	Shigella_phage	1.8e-30	30.8
WP_035756103.1\|74916_75963_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
77586:77602	attR	NA	NA	NA	NA

DBSCAN-SWA_2

1308541 : 1381277

Staphylococcus_phage(25.0%)

transposase,capsid,holin,portal,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_155225094.1\|1308541_1309777_-\|transposase	ISL3 family transposase	NA	NA	NA	NA
WP_155225059.1\|1310292_1311593_-\|transposase	IS3 family transposase	A0A1B3AZE5	Gordonia_phage	7.9e-56	42.1
WP_035750952.1\|1312929_1313700_-	hypothetical protein	NA	NA	NA	NA
WP_035751322.1\|1313703_1314801_-	DUF3071 domain-containing protein	NA	NA	NA	NA
WP_075863653.1\|1315033_1316179_-	phosphoserine transaminase	NA	NA	NA	NA
WP_075863654.1\|1317433_1318294_-	hypothetical protein	NA	NA	NA	NA
WP_081724778.1\|1320676_1321000_-	invasin	NA	NA	NA	NA
WP_075863655.1\|1321299_1322427_-	citrate synthase 2	NA	NA	NA	NA
WP_040004464.1\|1322554_1323289_+	pyridoxamine 5'-phosphate oxidase	NA	NA	NA	NA
WP_035750961.1\|1323378_1324647_+	MFS transporter	NA	NA	NA	NA
WP_035751328.1\|1324691_1325765_+	isopenicillin N synthase family oxygenase	NA	NA	NA	NA
WP_006361236.1\|1325868_1326990_-	DUF2236 domain-containing protein	NA	NA	NA	NA
WP_006361235.1\|1327035_1327305_-	DUF4235 domain-containing protein	NA	NA	NA	NA
WP_006361234.1\|1327328_1327586_-	DUF3618 domain-containing protein	NA	NA	NA	NA
WP_035750963.1\|1327586_1327982_-\|holin	phage holin family protein	NA	NA	NA	NA
WP_035750965.1\|1328053_1328926_-	biotin-dependent carboxyltransferase family protein	NA	NA	NA	NA
WP_006361231.1\|1328922_1329591_-	allophanate hydrolase subunit 1	NA	NA	NA	NA
WP_006361230.1\|1329649_1330588_+	carbohydrate kinase	NA	NA	NA	NA
WP_006361229.1\|1330648_1331971_+	citrate synthase	NA	NA	NA	NA
WP_005198205.1\|1332044_1332413_+	peptidyl-prolyl cis-trans isomerase	NA	NA	NA	NA
WP_035750968.1\|1332427_1333714_+	deoxyribodipyrimidine photo-lyase	A0A2H4UV63	Bodo_saltans_virus	3.0e-47	29.1
WP_035754856.1\|1339833_1341063_-	ABC transporter permease	NA	NA	NA	NA
WP_035754854.1\|1341059_1341956_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.8e-30	33.0
WP_035754851.1\|1341952_1342573_-	hypothetical protein	NA	NA	NA	NA
WP_006359706.1\|1342569_1342884_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_127963907.1\|1342963_1344067_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_006359708.1\|1344154_1344886_+	enoyl-CoA hydratase	NA	NA	NA	NA
WP_042376602.1\|1345007_1346117_+	XdhC family protein	NA	NA	NA	NA
WP_040004246.1\|1346119_1347442_-	FAD-binding protein	NA	NA	NA	NA
WP_035754846.1\|1347438_1348731_-	alanine racemase	NA	NA	NA	NA
WP_035754902.1\|1348714_1349338_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_035754900.1\|1349548_1350733_+	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_006359714.1\|1350729_1353216_+	HAD-IC family P-type ATPase	M1HBF8	Paramecium_bursaria_Chlorella_virus	3.9e-27	23.6
WP_006359715.1\|1353287_1353527_+	antitoxin	NA	NA	NA	NA
WP_006359716.1\|1353531_1354173_-	DNA-3-methyladenine glycosylase	NA	NA	NA	NA
WP_006359717.1\|1354150_1354588_+	SRPBCC family protein	NA	NA	NA	NA
WP_006359718.1\|1354675_1356388_+	VWA domain-containing protein	NA	NA	NA	NA
WP_006359719.1\|1356448_1356955_+	FMN-binding protein	NA	NA	NA	NA
WP_155225096.1\|1356981_1357869_+	FAD:protein FMN transferase	NA	NA	NA	NA
WP_006359721.1\|1357865_1359461_+	oxidoreductase	NA	NA	NA	NA
WP_155225098.1\|1359515_1360466_-	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	1.3e-28	30.0
WP_035754840.1\|1360462_1362115_-	L-glutamate gamma-semialdehyde dehydrogenase	NA	NA	NA	NA
WP_155225099.1\|1362190_1363798_+	PucR family transcriptional regulator	NA	NA	NA	NA
WP_006359725.1\|1363919_1366091_-	glutamine synthetase	NA	NA	NA	NA
WP_006359726.1\|1366282_1368220_-	gamma-glutamyltransferase family protein	Q5GF27	Diachasmimorpha_longicaudata_entomopoxvirus	6.6e-06	24.3
WP_035754832.1\|1368290_1369664_-	MFS transporter	NA	NA	NA	NA
WP_035754830.1\|1369803_1370244_+	SRPBCC family protein	NA	NA	NA	NA
WP_155225100.1\|1370251_1371883_-	MFS transporter	NA	NA	NA	NA
WP_006359730.1\|1371938_1372631_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_155225101.1\|1372781_1374005_+	DUF2236 domain-containing protein	NA	NA	NA	NA
WP_155225102.1\|1374087_1375365_-	acyltransferase family protein	NA	NA	NA	NA
WP_155225103.1\|1375895_1376213_-	hypothetical protein	NA	NA	NA	NA
WP_155225104.1\|1376212_1376530_-	hypothetical protein	NA	NA	NA	NA
WP_155225105.1\|1376609_1377440_-\|capsid	phage major capsid protein	NA	NA	NA	NA
WP_155225106.1\|1377575_1377926_-	hypothetical protein	NA	NA	NA	NA
WP_155225688.1\|1377946_1378306_-	hypothetical protein	NA	NA	NA	NA
WP_155225107.1\|1378428_1379796_-\|portal	phage portal protein	A0A2H5BLQ6	Streptomyces_phage	3.9e-29	29.7
WP_155225108.1\|1379810_1381277_-\|terminase	terminase large subunit	A0A2K9VGS4	Pontimonas_phage	1.3e-54	34.4

DBSCAN-SWA_3

2836676 : 2844255

Mycobacterium_phage(33.33%)

integrase,transposase

attL 2830340:2830354|attR 2848148:2848162

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2830340:2830354	attL	NA	NA	NA	NA
WP_155225710.1\|2836676_2836835_-	excisionase family DNA-binding protein	A0A2D1GJY6	Mycobacterium_phage	3.1e-07	55.1
WP_155225331.1\|2837067_2837742_-	hypothetical protein	NA	NA	NA	NA
WP_096273871.1\|2837853_2838144_-	helix-turn-helix domain-containing protein	A0A249XU22	Mycobacterium_phage	7.0e-05	40.0
WP_155225711.1\|2838440_2839208_-\|integrase	tyrosine-type recombinase/integrase	A0A2P1CI94	Actinomyces_phage	6.1e-24	38.5
WP_075863973.1\|2839226_2840738_+\|transposase	IS21 family transposase	A0A2L1IVA1	Escherichia_phage	7.1e-16	27.6
WP_006361228.1\|2840734_2841520_+	ATP-binding protein	U5N3V8	Enterobacteria_phage	3.7e-32	34.5
WP_155225712.1\|2841545_2842136_-	hypothetical protein	NA	NA	NA	NA
WP_081724790.1\|2842667_2843273_+	hypothetical protein	NA	NA	NA	NA
WP_155225332.1\|2843355_2844255_+	ATP-binding cassette domain-containing protein	A0A2H4PQG7	Staphylococcus_phage	3.0e-22	28.2
2848148:2848162	attR	NA	NA	NA	NA

DBSCAN-SWA_4

3521816 : 3530949

Gordonia_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_155225416.1\|3521816_3524828_+	ATP-dependent helicase	A0A2K9VEG9	Gordonia_phage	2.4e-39	28.0
WP_006359434.1\|3524824_3525634_+	hypothetical protein	NA	NA	NA	NA
WP_006359435.1\|3525681_3526686_-	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A160DHK0	Gordonia_phage	2.0e-155	86.5
WP_006359436.1\|3526754_3528950_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	V9VI16	Lactococcus_phage	1.4e-209	51.6
WP_006359437.1\|3529049_3529514_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	Q4Z9B0	Staphylococcus_phage	4.7e-11	31.7
WP_005198719.1\|3529740_3529977_-	redoxin NrdH	V5UN81	Mycobacterium_phage	5.1e-22	62.8
WP_006359438.1\|3530391_3530949_-	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	3.4e-08	29.8

DBSCAN-SWA_5

4314216 : 4359950

Leptospira_phage(28.57%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_006360329.1\|4314216_4315605_+\|transposase	IS1380-like element ISGosp1 family transposase	NA	NA	NA	NA
WP_005198135.1\|4316101_4316947_+	3-hydroxybutyryl-CoA dehydrogenase	NA	NA	NA	NA
WP_035754513.1\|4317206_4318223_+	hypothetical protein	NA	NA	NA	NA
WP_006359792.1\|4318432_4318897_+	cupin domain-containing protein	NA	NA	NA	NA
WP_035754652.1\|4318930_4319674_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_006359790.1\|4319867_4320299_+	transcriptional repressor	NA	NA	NA	NA
WP_005198130.1\|4320348_4322574_+	catalase/peroxidase HPI	NA	NA	NA	NA
WP_005198129.1\|4322725_4323091_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_006359788.1\|4323087_4324755_+	SulP family inorganic anion transporter	NA	NA	NA	NA
WP_006359787.1\|4324975_4327216_+	NADP-dependent isocitrate dehydrogenase	NA	NA	NA	NA
WP_040004259.1\|4327291_4328023_+	hypothetical protein	NA	NA	NA	NA
WP_006359784.1\|4329282_4329990_+	type 1 glutamine amidotransferase	NA	NA	NA	NA
WP_006359783.1\|4330044_4331118_-	ADP-ribosylglycohydrolase family protein	A0A1I9SA26	Rhodococcus_phage	2.3e-16	29.5
WP_006359781.1\|4332023_4332425_+	hypothetical protein	NA	NA	NA	NA
WP_006359780.1\|4332424_4332790_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_006361228.1\|4333074_4333860_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	3.7e-32	34.5
WP_155225741.1\|4333856_4335575_-\|transposase	IS21 family transposase	A0A2L1IVA1	Escherichia_phage	5.4e-12	27.1
WP_006359316.1\|4335878_4336169_+\|transposase	transposase	NA	NA	NA	NA
WP_155225531.1\|4336162_4336969_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	1.9e-28	33.3
WP_006359128.1\|4340040_4340520_-	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_006359127.1\|4340941_4341982_+	diiron oxygenase	NA	NA	NA	NA
WP_042378911.1\|4342013_4343528_+	4Fe-4S dicluster domain-containing protein	NA	NA	NA	NA
WP_042378920.1\|4343807_4345358_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_006359124.1\|4345948_4346863_+	metal-dependent hydrolase	NA	NA	NA	NA
WP_035754036.1\|4347274_4348267_-\|transposase	IS481 family transposase	E9P643	Wolbachia_endosymbiont_wVitB_of_Nasonia_vitripennis_phage	2.6e-06	24.9
WP_042378923.1\|4348660_4348879_+	hypothetical protein	NA	NA	NA	NA
WP_155225532.1\|4349078_4349831_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_155225743.1\|4349912_4350830_-	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_035756060.1\|4350834_4351905_-	ferredoxin--NADP reductase	Q58M74	Prochlorococcus_phage	2.5e-07	40.9
WP_006361210.1\|4351901_4352771_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_006361211.1\|4352810_4354334_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_006361212.1\|4354492_4355461_-	diiron oxygenase	NA	NA	NA	NA
WP_006361213.1\|4355594_4355936_+	DUF4873 domain-containing protein	NA	NA	NA	NA
WP_155225533.1\|4356002_4359083_+	MMPL family transporter	NA	NA	NA	NA
WP_155225534.1\|4359350_4359950_-\|transposase	transposase	S5WIU1	Leptospira_phage	1.8e-26	33.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP046257

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection