CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP018187	Streptococcus salivarius strain ICDC2, complete genome	2 crisprs	RT,DEDDh,csa3,cas3,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,cas2,DinG,WYL	0	16	8	0
NZ_CP018188	Streptococcus salivarius strain ICDC2 plasmid, complete sequence	1 crisprs	NA	0	1	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP018187_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018187_1

230389-230584

Orphan

Consensus_repeat	Method
AAACTTGTCAACATTGTTGTGAAATAA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP018187_1

>merge|NZ_CP018187|1|230389-230584|CRISPRCasFinder
AAACTCGTTAATATTGTCGTTAAATAACGAGTTTATTAGCCTTATCTGCTACCTTCAACAGTCCACTGGACTATTGAAGCCGAACAAACTTGTCAACATTGTTGTGAAATAACCGATTTATTTGTTCATGCTCAACCTCAAACAGTTTCCCAAACTGTTTGAGCCTAATAAACTTGTTAACATTGTTGTGAAATAA

>NZ_CP018187|1|1|230389-230584|CRISPRCasFinder
AAACTCGTTAATATTGTCGTTAAATAA	CGAGTTTATTAGCCTTATCTGCTACCTTCAACAGTCCACTGGACTATTGAAGCCGAAC
AAACTTGTCAACATTGTTGTGAAATAA	CCGATTTATTTGTTCATGCTCAACCTCAAACAGTTTCCCAAACTGTTTGAGCCTAAT
AAACTTGTTAACATTGTTGTGAAATAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018187.1\|WP_002883644.1\|224864_225404_+\|transcription-termination/antitermination-protein-NusG	unknown	unknown	gnl\|CDD\|180161
NZ_CP018187.1\|WP_156247076.1\|235643_236099_+\|LytTR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|335768
NZ_CP018187.1\|WP_156246349.1\|230680_231136_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP018187.1\|WP_155164413.1\|221950_224278_+\|PBP1A-family-penicillin-binding-protein	unknown	unknown	gnl\|CDD\|273955
NZ_CP018187.1\|WP_002883656.1\|224487_224664_+\|preprotein-translocase-subunit-SecE	unknown	unknown	gnl\|CDD\|236066
NZ_CP018187.1\|WP_156246351.1\|233473_233791_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP018187.1\|WP_156246347.1\|226952_227720_-\|DeoR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP018187.1\|WP_060973135.1\|225530_226019_+\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239489
NZ_CP018187.1\|WP_156246350.1\|233080_233386_-\|GTP-cyclohydrolase	unknown	unknown	gnl\|CDD\|225225
NZ_CP018187.1\|WP_003095191.1\|232567_232981_+\|YjdF-family-protein	unknown	unknown	gnl\|CDD\|378596
NZ_CP018187.1\|WP_037600208.1\|236108_236534_+\|DUF3021-family-protein	unknown	unknown	gnl\|CDD\|378668
NZ_CP018187.1\|WP_155164414.1\|221015_221885_-\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NZ_CP018187.1\|WP_156246346.1\|226150_226960_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|319818
NZ_CP018187.1\|WP_156246353.1\|234782_235625_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|366444
NZ_CP018187.1\|WP_156246354.1\|236623_237334_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133381
NZ_CP018187.1\|WP_002886472.1\|224326_224479_+\|50S-ribosomal-protein-L33	unknown	unknown	gnl\|CDD\|234783
NZ_CP018187.1\|WP_156246352.1\|233916_234783_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP018187.1\|WP_037600215.1\|237552_238236_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP018187.1\|WP_073689661.1\|220193_220499_-\|DUF2752-domain-containing-protein	unknown	unknown	gnl\|CDD\|378499
NZ_CP018187.1\|WP_013989998.1\|220498_220831_-\|TM2-domain-containing-protein	unknown	unknown	gnl\|CDD\|377473

Protein	Function_ID	Function_description	E-value
NZ_CP018187.1\|WP_002883644.1\|224864_225404_+\|transcription-termination/antitermination-protein-NusG	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	3.28618e-82
NZ_CP018187.1\|WP_156247076.1\|235643_236099_+\|LytTR-family-transcriptional-regulator	gnl\|CDD\|335768	pfam04397, LytTR, LytTr DNA-binding domain. This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.	1.12582e-20
NZ_CP018187.1\|WP_156246349.1\|230680_231136_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	4.82158e-12
NZ_CP018187.1\|WP_155164413.1\|221950_224278_+\|PBP1A-family-penicillin-binding-protein	gnl\|CDD\|273955	TIGR02074, Includes:_Penicillin-insensitive_transglycosylase, penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NZ_CP018187.1\|WP_002883656.1\|224487_224664_+\|preprotein-translocase-subunit-SecE	gnl\|CDD\|236066	PRK07597, secE, preprotein translocase subunit SecE; Reviewed.	2.68913e-10
NZ_CP018187.1\|WP_156246351.1\|233473_233791_+\|transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	1.4703e-28
NZ_CP018187.1\|WP_156246347.1\|226952_227720_-\|DeoR-family-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	2.88571e-68
NZ_CP018187.1\|WP_060973135.1\|225530_226019_+\|phosphatase-PAP2-family-protein	gnl\|CDD\|239489	cd03395, PAP2_like_4, PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	1.81367e-12
NZ_CP018187.1\|WP_156246350.1\|233080_233386_-\|GTP-cyclohydrolase	gnl\|CDD\|225225	COG2350, COG2350, Uncharacterized protein conserved in bacteria [Function unknown].	7.56746e-19
NZ_CP018187.1\|WP_003095191.1\|232567_232981_+\|YjdF-family-protein	gnl\|CDD\|378596	pfam11208, DUF2992, Protein of unknown function (DUF2992). This bacterial family of proteins has no known function. However, the cis-regulatory yjdF motif, just upstream from the gene encoding the proteins for this family, is a small non-coding RNA, Rfam:RF01764. The yjdF motif is found in many Firmicutes, including Bacillus subtilis. In most cases, it resides in potential 5' UTRs of homologs of the yjdF gene whose function is unknown. However, in Streptococcus thermophilus, a yjdF RNA motif is associated with an operon whose protein products synthesize nicotinamide adenine dinucleotide (NAD+). Also, the S. thermophilus yjdF RNA lacks typical yjdF motif consensus features downstream of and including the P4 stem. Thus, if yjdF RNAs are riboswitch aptamers, the S. thermophilus RNAs might sense a distinct compound that structurally resembles the ligand bound by other yjdF RNAs. On the ohter hand, perhaps these RNAs have an alternative solution forming a similar binding site, as is observed with some SAM riboswitches.	5.12172e-42
NZ_CP018187.1\|WP_037600208.1\|236108_236534_+\|DUF3021-family-protein	gnl\|CDD\|378668	pfam11457, DUF3021, Protein of unknown function (DUF3021). This is a bacterial family of uncharacterized proteins.	1.01948e-08
NZ_CP018187.1\|WP_155164414.1\|221015_221885_-\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	2.81698e-84
NZ_CP018187.1\|WP_156246346.1\|226150_226960_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|319818	cd07516, HAD_Pase, phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily. Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.31368e-74
NZ_CP018187.1\|WP_156246353.1\|234782_235625_+\|ABC-transporter-permease	gnl\|CDD\|366444	pfam01061, ABC2_membrane, ABC-2 type transporter.	0.000133095
NZ_CP018187.1\|WP_156246354.1\|236623_237334_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	2.40314e-44
NZ_CP018187.1\|WP_002886472.1\|224326_224479_+\|50S-ribosomal-protein-L33	gnl\|CDD\|234783	PRK00504, rpmG, 50S ribosomal protein L33; Validated.	2.86471e-18
NZ_CP018187.1\|WP_156246352.1\|233916_234783_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	5.14053e-81
NZ_CP018187.1\|WP_037600215.1\|237552_238236_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	1.14892e-101
NZ_CP018187.1\|WP_073689661.1\|220193_220499_-\|DUF2752-domain-containing-protein	gnl\|CDD\|378499	pfam10825, DUF2752, Protein of unknown function (DUF2752). This family is conserved in bacteria. Many members are annotated as being putative membrane proteins.	1.1624e-06
NZ_CP018187.1\|WP_013989998.1\|220498_220831_-\|TM2-domain-containing-protein	gnl\|CDD\|377473	pfam05154, TM2, TM2 domain. This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.	7.80642e-12

>NZ_CP018187.1|WP_156246347.1|226952_227720_-|DeoR-family-transcriptional-regulator
MYQEQRLEKILTLLEERGNLSVKEMVDELGVSKDTVRRDFDCLSQRNLAQRTHGGILPVKNTTVLGFQERQKGLTEDKKKMADLALSLVKDQSLLFFDVSTLMLEVSQKLTKKVTIYSHSLDNALVLSGKEGVDFHLLGGRFYSKNRFYYSLHEAQLLQHLQFDLAFFGAASLNQGVVSYEDEEDVAVKQLAMQAARTKVLIAESDKYEKHSKYILGKIKDFDYWITDKKPDPDLVEALKDRVTILYDGKDSDYE
>NZ_CP018187.1|WP_156246346.1|226150_226960_-|Cof-type-HAD-IIB-family-hydrolase
MNNIRLIISDIDGTILTSNHQVDEQLIEVMPELEKANIPFVLASARSPLGMQPIAHKLGLHDNPIACYNGALVLEGDRTIIQHPVDKAEIQELLSYLSTDYPSVSVNIYSGKDWITNKLDKWSQLEGSITGESPMIKELQDTVSDSEPPIHKLLLIDEPEVIQDLHQKLLSMDFTQTAFYLSKDNYLEVTAKHVSKEHALIEVAKYYDLPLEEVMTIGDNFNDSPMLALAGLGIAMGNAPEGVKETANLVTTSNDEHGVAQAITEHVLN
>NZ_CP018187.1|WP_060973135.1|225530_226019_+|phosphatase-PAP2-family-protein
MMNYKRFYDRISTPLRPYAKVLEGLNKIITRTFYLLFPIFLIWVLLRGGWFILSTTVLIMGGGFFLLSLGRSLYNRPRPYQTWAIQSLIKKDSLGKSFPSRHVFSATVIAMLALTLNPWLGGAMLFLAGALALLRVLGGVHYPSDVLAGYVIGILVGLLLYL
>NZ_CP018187.1|WP_002883644.1|224864_225404_+|transcription-termination/antitermination-protein-NusG
MLDSFDKGWFVLQTYSGYENKVKENLLQRAQTYNMLENILRVEIPTQTVNVEKNGKVKEVEENRFPGYVLVEMVMTDEAWFVVRNTPNVTGFVGSHGNRSKPTPLLEEEIRQILISMGQTVDVFDTNIKVGDVVQIIDGAFMGQEGRVVEIENNKVKIMINMFGSETAAELELYQIAEL
>NZ_CP018187.1|WP_002883656.1|224487_224664_+|preprotein-translocase-subunit-SecE
MRQTGSIFKVLKDTTWPDRKQRWHDFISVLEYTAFFTVIIYAFDELLSRAMSALINFF
>NZ_CP018187.1|WP_002886472.1|224326_224479_+|50S-ribosomal-protein-L33
MAQKKASLACAECGSRNYSINVSSTPKPTRLEVNKFCKHCKKYTLHKETR
>NZ_CP018187.1|WP_155164413.1|221950_224278_+|PBP1A-family-penicillin-binding-protein
MTFFDNLKNKLFKEETSGKGKESQPAGKSKDLQDKIKGLFAKKPDEVEQAVEDLDMSQESKETSRYQRSKQKKPIDTTKPLGKVQAFLSKFTLSPRNPIRRFWRRYHIGKILFIMLAVLVLTVGSYLFYIAKTTNVSDLQDALKATTVIYDKEGNQAGSLSGQKGTYVELDAISDSLENAVIATEDRTFYKNSGVNVKRFLLAIVSMGRFGGGSTITQQLAKNAFLTQEQTVTRKAKEFFLSLELTKKYSKQEILTMYLNNAYFGNGVWGVEDASQKYFGTSAANLTVDEAATLAGMLKGPEIYNPIDNIQNATNRRNTVLANMVDDKKLSQADADSAAGVDMASRLDDTYQGTGDDYKYPSYFDAVIEEATKTYGLSEDEIVKNGYKIYTEMDANSQANMQQTYENTYLFPTSESDGSTAQSASVALDPTTGAVRGLVGRVGGTSDTTFRNFNYATQGKRSPGSTIKPLVVYAPALASGWSINKDLPNKPIDYNGYTPTNYGDIETEDVPMYQALANSYNVPAVYLFNQIGIQKGISYGQKFGLNFDNVPEELGISLGGGVTASPLQMAQAYATFANGGEMNTAYFITKIENASGDIIATHSKKSKRVISQSVANQMTSMMLGTFSNGSAVNANYTGYTMAGKTGTVQAEFNKDLTSDQWVIGYTPDVVMTTWIGFDKTDESHYLTGASSGTASTIFSYIAADVLPNTPGTEFTVENAYAADGQTLDYTADPNDSRNSSNKSWTDKASDVVNDVKDQASSLWDKITDSFSGLFR
>NZ_CP018187.1|WP_155164414.1|221015_221885_-|RluA-family-pseudouridine-synthase
MTLHVEIINPYPATTVKDLLETKLLIPRKIRHFLRTKKHVLINGEAINWQSPVEKCDKISLTFDREDYPEKIIPMGNANLIEPLYEDPHLIVVNKPEGMKTHGNEPTEIALLNHVSAYCGQTCYVVHRLDMETSGAVLFAKNPFILPILNRLLEDKKIQRQYWALAEGKFQTKETVYNDKIGRDRHDRRKRVVEPRKGQVAYTTVTRLKAFKGASLVNCQLKTGRTHQIRVHLAHHGHAILGDPLYSHRPASRLMLHAHTLCFTHPLTLEKITVKASSDSFEKGLRNHK
>NZ_CP018187.1|WP_013989998.1|220498_220831_-|TM2-domain-containing-protein
MNPVDQWITINAKYFPTEQVQYIRQRLEALPEQQLSMLYSISFQDPTMLLIISLLGGTLGIDRFLLGQIGLGVGKLLTCGGCGIWSIVDLFLIMDATRQSNAQKLFAVIG
>NZ_CP018187.1|WP_073689661.1|220193_220499_-|DUF2752-domain-containing-protein
MKNYFTRLWAYHQRFFRLYLLVLVAVYGVYLLHLPTPLSLILRPFGLKAWSAGLTRASVRLLHLDWQGAWDYNPLIYPLVVYILTYFFLFPIFSDKKIIRK
>NZ_CP018187.1|WP_156246349.1|230680_231136_+|MarR-family-transcriptional-regulator
MNKKELHKFNNRFNSFVLAFERLKKNQHRNSIDKSITINEVHLIDLIGRNQPVNLVKLSELLEVSRSAVTQSVRRLTKKDLVAFEFAPDNEKNKYLILSKKGVDVFNVHKEQQEHIEKTIFSVLRNYSEADLQMVMKLMDDVEQVWRELPW
>NZ_CP018187.1|WP_003095191.1|232567_232981_+|YjdF-family-protein
METISIGLTVYFEDGFWHGLFEQVYLETYQVCRVTFGQEPKDDEILEILQTQFTQLSFSPEAIVKQHVKVKNPKRLQRMVKKQVNQKVSSKSKELLQLQYEERKKISKHQSSVQKQLLKQEKFERKQQKRREKHKGH
>NZ_CP018187.1|WP_156246350.1|233080_233386_-|GTP-cyclohydrolase
MFIVNLTYIKSLDEVEKHLEKHIDFLNQYYTKGLFIASGRKNPRTGGIILMRAKNKEAVQEIITHDPFYQNEIAQYEIIEFEASKYCPEFETIVSKSFDDK
>NZ_CP018187.1|WP_156246351.1|233473_233791_+|transcriptional-regulator
MLTNKNWNCSMSRVLDVVGGKWRMNILWVINKHKRVRFNQLRREVEGITTISLTRGLDVLIENQLIEKYDYESLPLHTEYELTEKGKSLMPILKDLNQWGKEWLQ
>NZ_CP018187.1|WP_156246352.1|233916_234783_+|ATP-binding-cassette-domain-containing-protein
MILQAKNISKRYGNHLAVDHIHLQFEKGTFNAILGPNGAGKSTTISMLIGLKQPTQGDIIYEPGTKIGVVFQTSVLDEMLTVRENLTIRARQYKGLKPNRVSDLIDRLGLSAFQKQKYGTLSGGQKRRVDIARALLHGPGLLFLDEPTTGLDIQTRKSIWDLLYQLQREEGMTVVLTTHYLDEADEADQIYIVDHGKVIAQGSALDIKSQYAKNILKIRFKEIQQIESLKTSGMSVEQQSQLEYVFQPDSEREAIDYLAQVRDKLAHFEFRPGTMDDAFIALTGREVR
>NZ_CP018187.1|WP_156246353.1|234782_235625_+|ABC-transporter-permease
MLALLKRNFLLYFRNRSGVFFSLLGALISFVLYIIFLQKNLTDAWAQLPNSGPVLNNWLMSGTLAVTGITTSLAALTQLVKDREHQVDQDLYLSDQGIWRLPSSYLASAIIISLSMQVLMYVLMCGYFREVPKLSILPEVLLIMLLSSLLSSLVNAIFVHFFQSVDSLGKFATIVGTASGFLVGTYVPLGVLPDFAQLLMKCTPATYIASLYRQVLMNETLSETFKGQDDLRQEFQEKMGVQLKWQELLTKENTYLIVLGGILLVGILWAILVKKSSKKK
>NZ_CP018187.1|WP_156247076.1|235643_236099_+|LytTR-family-transcriptional-regulator
MKLRFEEKSDISTKDPCVVIQAERLSDQAREVMDYLEQFSVVNQVVIPIKTNDHLVMVKIDDIILAEIDKNVLTIYTIDKTYTMKETLTNFQHRINRRSFLQISRHAVMNIDHLESLSDSFSGNMMAKMTGGVKSSVSRKYVKSLMDYLGV
>NZ_CP018187.1|WP_037600208.1|236108_236534_+|DUF3021-family-protein
MKRFIAYFVSGVRTGSFFYLALLLLGQLFPQIIYPKVSVGNILALFMMSGLMGMLSWILEDLDRMSYRLRVILHFLLTAIVLIGTCLIAGWIDAVLNPIIWIVFISVYIIIWLYLIWQMHMRTQRINQALIHRRSQKKKEK
>NZ_CP018187.1|WP_156246354.1|236623_237334_+|MerR-family-transcriptional-regulator
MKSVKEVSQLSGVSVRTLHYYDEIDLLKPSIVAENGYRYYNRDAVVRLQEILLYRELDFPLKKIKEIVGQAGYDKVQALKDQIKLLELKKSHLEAVIAHAKALQMEEEEMSFEAFDQKAMEEFQQEAQARWGQTEAYQAFAAKGEEPFPEVTKEMTAIMFTFGQLKESNPDDNSVQEQVKVLQDYISQHFYPCDQTVLAGLGQMYQTDNRFSSFIDKVGGSGTAVFLAEAIRIYCQ
>NZ_CP018187.1|WP_037600215.1|237552_238236_+|ABC-transporter-ATP-binding-protein
MSILTIDHISKYYDLDGTNQERALNDVTLEIAPAKITAIYGPSGCGKTSLLSIISGLDSQYQGNLYFKNQNMRDFSERDLTYFRKAHIGFVFQNFNLIPHQSVLENVKMPLYVKNMTDKEMIEIAEKELSRLGIGEFIKKNVKQLSGGQKQRVAIARALVNNPEMIVADEPTGSLDSQSQENVLEIFKELAEAGKTVIIVTHNPEVADYADVVIKMKDGEVVETIEK

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Crispr_ID: NZ_CP018187_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018187_2

1139218-1141784

TypeIII

II-B,III-A:NA

Consensus_repeat	Method
GTTNCCGTCCCCTCNCGAGGT	CRT
CTCTCGAGGTATATAGGTTTATATC	CRISPRCasFinder
GGTTTCCGTCCCCTCTCGAGGTGAATAGGTTTATATCAC	PILER-CR

35 spacers

cas6,cas10,csm2gr11,csm3gr7,csm4gr5,csm5gr7,csm6,cas2

The CRISPR arrays of NZ_CP018187_2

>merge|NZ_CP018187|2|1139218-1141784|CRT,CRISPRCasFinder,PILER-CR
AAAAAGGTCCCCTCTCGAGGTATATAGGTTTATATCAAAGAAGCGAACGCTCACAATATGCTATTGAAAGTGTTCCCGTCCCCTCTCGAGGTAGATAGATTTATATCAGACAAAATACTAGCTATCCTTAATCAAAAGGGAGGGTTTCCGTCCCCTCTCGAGGTATATAGGTTTATATCGCAGTGTCTGTATTCGCACGTCCTGCCAAAGCGCAAGCGTTTCCGTCCCCTCGCGAGGTGGATAGGTTTATATCACAGCAGCGGCAATTTCACACCGTATTCAAAATGGTTTCCGTCCCTTCGCAAGGTAGGTAGGTTTATATCCCTTGAAACTATTATGACTATTCAAAAGTGGATTGAGTTTCCGTCCCCTTGCGAGGTGAGTAGGTTTATATCTGCAGATTTAACTATTTTTAGTTAAACAAAAGCAGTTTCCGTCCCCTCTCGAGGTAGATAGGTTTATATCAATGATTTTACACGTAAGGTAATTAATAAACGGTTTCCGTCCCCTCTCGAGGTAAATAGGTTTATATCCAAGGAAAAATCGAATTAGGTCTAGTTTCAGGCCGTCGTTTCCGTCCTCTCGCGAGGTGAATAGGTTTACATCCGTAAGTCAAACTCAGAGTAAAGAAACATCAACAAGGTTTCCGTCCCCTCGCGAGGTATATAGGTTTATATCCGAATGGATTGAAAAAAACTTGGAGAATATCCGATAGTTTCCGTCCCCTCACGAGGTAAATAGGTTTATATCTCAATGAAATGAAACAGGACAACGCTTTATAATATGTTTCCATCCCCTCTTGAGGTATATGGGTTTATATCAAAACGAAAACCTCTTGATTGAGTTGGAAGAAGCAAAGTTACCGTCCCCTCTCGAGGTATATAGGTTTATATCGTAGTCTTGATGATTTGATTAGTTATAAGTCTTTGGGTTTCCGTCCCCTCTCAAGGTACATAGGTTTATATCCCATGATAAGAGTGCTTCTACATTAAATCTCGTAATGGGTTACCGTCCCCTCGCGAGATAAATAGGTTTATATCTAAAACATTGAAACATGACACGGTGGGGCTATGGGTGTTACCGTCCCCTCTCGAGGTGAATAGGTTTATATCTTAAAGGTCATTCTGCACGAATTAGGACGCTCAGATGTTCCGTCTCCTCTCGAGGTGGATAGGTTTATATCGCAAAGGAACATTAGCTATCAATCAATCAAAAGATGAGTTTCCGTCCCCTCGCGAGGTGGATAGGTTTATATCACTTCAAGAATTGCAAGAATACGCTTTTAACGTTTTGGTTTCCGTCCCCTCGCGAGGTAGATAGGGTTATATCAGTTCGTAAAATATGATGATACATACAAAGAAGAAGCCAGTTACCGTCCCCTCCCGAGGTAAATAGGGTTATATCTCCCAGACGATATTCCAGTAAACGAAGGTGACAAGGTGTTTCCGTCCCCTCGCGAGGCATATAGGTTTATATCCCTGTGGTTATGACGGAAAAGCCCAACAAGAATTTATGTTACCGTCCCCTCCCGAGGTATATAGGTTTATATCACAGCATTTCCAAGGTTATATAGACGCTGTGGTTGTGGAGTTTCCGTCCCCTCGCGAGGCATATAGGTTTATATCTAATGGACGCACAAACAAAAGCAACCAAGAAATGGAAGTTACCGTCCCCTCACGAGGTGAATAGGTTTGTATCAGCAGGACTAGACAAGGATACATTCAAGGACAAGTACGGTTTCCGTCCCCTTGCGAGGTATATAGGTTTATATCTCAGATTGACGATGAGATATATAGCGATATTTAGTTGTTTCCGTCCACTCGCGAGGTATATAGGTTTATACCAGTAAACAAACTTGTTGAGCTATATGTATCTGAAAATGGTTACCGTCCCCTCCCGAGGTACATAGGTTTATAGCGCACCTCTACCTGAAGCGGATGAACCGCAACCTTTGAGTTTCCGTCCCCTCTCGAGGTGGATAGGTTTATATCAAGATATTCATTACTACAAGGAATTTGTGGATTGTTACCGTCCCCTCCCGAGGTACACAGGTTTATATCGAAAGTAAAAACATTTACAAGGAGATTATATCATGACAGTTACCGTCCCCTCGCGAGGTGGATAGGTTTATATCGGGCAACTAATTAGCGTAAGCGGACGACTTCAAAGAGTTATCGTCCCCTCTCGAGGTATATAGGGTTATATCGTTAAGAATAAGGAGAAAATAAAATGTTGGGTTGGTTTCCGTCCCCTCGCGAGGTGAATAGGTTTATATCCTACTTTGTGAAAGACATGAGAAAAACAGCCTTAGTATGACCGTCCTCTCTCGAGGTATATAGGTTTATATCGTAATGACAAAGACACATTTATGATTAAAGGTCTATGGTTACCGTCCCCTCTCGAGGTAAATAGGTTTATATCTCGTTGCTTACCACGACGCTGAAAATGCACTTATGGGGTTTCCGTCCCCTCTCGAGGTGAATAGGTTTATATCACTTTCTGATTGGACTTTTGAATTCATTACATTTAGTTTCCGTCCCCTCTCGAGGTGAATAGGTTTATATCCC

>NZ_CP018187|2|1|1139218-1141767|CRT
AAAAAGGTCCCCTCTCGAGGT	ATATAGGTTTATATCAAAGAAGCGAACGCTCACAATATGCTATTGAAAGT
GTTCCCGTCCCCTCTCGAGGT	AGATAGATTTATATCAGACAAAATACTAGCTATCCTTAATCAAAAGGGAGG
GTTTCCGTCCCCTCTCGAGGT	ATATAGGTTTATATCGCAGTGTCTGTATTCGCACGTCCTGCCAAAGCGCAAGC
GTTTCCGTCCCCTCGCGAGGT	GGATAGGTTTATATCACAGCAGCGGCAATTTCACACCGTATTCAAAATG
GTTTCCGTCCCTTCGCAAGGT	AGGTAGGTTTATATCCCTTGAAACTATTATGACTATTCAAAAGTGGATTGA
GTTTCCGTCCCCTTGCGAGGT	GAGTAGGTTTATATCTGCAGATTTAACTATTTTTAGTTAAACAAAAGCA
GTTTCCGTCCCCTCTCGAGGT	AGATAGGTTTATATCAATGATTTTACACGTAAGGTAATTAATAAACG
GTTTCCGTCCCCTCTCGAGGT	AAATAGGTTTATATCCAAGGAAAAATCGAATTAGGTCTAGTTTCAGGCCGTC
GTTTCCGTCCTCTCGCGAGGT	GAATAGGTTTACATCCGTAAGTCAAACTCAGAGTAAAGAAACATCAACAAG
GTTTCCGTCCCCTCGCGAGGT	ATATAGGTTTATATCCGAATGGATTGAAAAAAACTTGGAGAATATCCGATA
GTTTCCGTCCCCTCACGAGGT	AAATAGGTTTATATCTCAATGAAATGAAACAGGACAACGCTTTATAATAT
GTTTCCATCCCCTCTTGAGGT	ATATGGGTTTATATCAAAACGAAAACCTCTTGATTGAGTTGGAAGAAGCAAA
GTTACCGTCCCCTCTCGAGGT	ATATAGGTTTATATCGTAGTCTTGATGATTTGATTAGTTATAAGTCTTTGG
GTTTCCGTCCCCTCTCAAGGT	ACATAGGTTTATATCCCATGATAAGAGTGCTTCTACATTAAATCTCGTAATGG
GTTACCGTCCCCTCGCGAGAT	AAATAGGTTTATATCTAAAACATTGAAACATGACACGGTGGGGCTATGGGT
GTTACCGTCCCCTCTCGAGGT	GAATAGGTTTATATCTTAAAGGTCATTCTGCACGAATTAGGACGCTCAGA
TGTTCCGTCTCCTCTCGAGGT	GGATAGGTTTATATCGCAAAGGAACATTAGCTATCAATCAATCAAAAGATGA
GTTTCCGTCCCCTCGCGAGGT	GGATAGGTTTATATCACTTCAAGAATTGCAAGAATACGCTTTTAACGTTTTG
GTTTCCGTCCCCTCGCGAGGT	AGATAGGGTTATATCAGTTCGTAAAATATGATGATACATACAAAGAAGAAGCCA
GTTACCGTCCCCTCCCGAGGT	AAATAGGGTTATATCTCCCAGACGATATTCCAGTAAACGAAGGTGACAAGGT
GTTTCCGTCCCCTCGCGAGGC	ATATAGGTTTATATCCCTGTGGTTATGACGGAAAAGCCCAACAAGAATTTAT
GTTACCGTCCCCTCCCGAGGT	ATATAGGTTTATATCACAGCATTTCCAAGGTTATATAGACGCTGTGGTTGTGGA
GTTTCCGTCCCCTCGCGAGGC	ATATAGGTTTATATCTAATGGACGCACAAACAAAAGCAACCAAGAAATGGAA
GTTACCGTCCCCTCACGAGGT	GAATAGGTTTGTATCAGCAGGACTAGACAAGGATACATTCAAGGACAAGTACG
GTTTCCGTCCCCTTGCGAGGT	ATATAGGTTTATATCTCAGATTGACGATGAGATATATAGCGATATTTAGTT
GTTTCCGTCCACTCGCGAGGT	ATATAGGTTTATACCAGTAAACAAACTTGTTGAGCTATATGTATCTGAAAATG
GTTACCGTCCCCTCCCGAGGT	ACATAGGTTTATAGCGCACCTCTACCTGAAGCGGATGAACCGCAACCTTTGA
GTTTCCGTCCCCTCTCGAGGT	GGATAGGTTTATATCAAGATATTCATTACTACAAGGAATTTGTGGATT
GTTACCGTCCCCTCCCGAGGT	ACACAGGTTTATATCGAAAGTAAAAACATTTACAAGGAGATTATATCATGACA
GTTACCGTCCCCTCGCGAGGT	GGATAGGTTTATATCGGGCAACTAATTAGCGTAAGCGGACGACTTCAAAGA
GTTATCGTCCCCTCTCGAGGT	ATATAGGGTTATATCGTTAAGAATAAGGAGAAAATAAAATGTTGGGTTG
GTTTCCGTCCCCTCGCGAGGT	GAATAGGTTTATATCCTACTTTGTGAAAGACATGAGAAAAACAGCCTTAGT
ATGACCGTCCTCTCTCGAGGT	ATATAGGTTTATATCGTAATGACAAAGACACATTTATGATTAAAGGTCTATG
GTTACCGTCCCCTCTCGAGGT	AAATAGGTTTATATCTCGTTGCTTACCACGACGCTGAAAATGCACTTATGGG
GTTTCCGTCCCCTCTCGAGGT	GAATAGGTTTATATCACTTTCTGATTGGACTTTTGAATTCATTACATTTA
GTTTCCGTCCCCTCTCGAGGT

>NZ_CP018187|2|2|1139229-1141782|CRISPRCasFinder
CTCTCGAGGTATATAGGTTTATATC	AAAGAAGCGAACGCTCACAATATGCTATTGAAAGTGTTCCCGTCCC
CTCTCGAGGTAGATAGATTTATATC	AGACAAAATACTAGCTATCCTTAATCAAAAGGGAGGGTTTCCGTCCC
CTCTCGAGGTATATAGGTTTATATC	GCAGTGTCTGTATTCGCACGTCCTGCCAAAGCGCAAGCGTTTCCGTCCC
CTCGCGAGGTGGATAGGTTTATATC	ACAGCAGCGGCAATTTCACACCGTATTCAAAATGGTTTCCGTCCC
TTCGCAAGGTAGGTAGGTTTATATC	CCTTGAAACTATTATGACTATTCAAAAGTGGATTGAGTTTCCGTCCC
CTTGCGAGGTGAGTAGGTTTATATC	TGCAGATTTAACTATTTTTAGTTAAACAAAAGCAGTTTCCGTCCC
CTCTCGAGGTAGATAGGTTTATATC	AATGATTTTACACGTAAGGTAATTAATAAACGGTTTCCGTCCC
CTCTCGAGGTAAATAGGTTTATATC	CAAGGAAAAATCGAATTAGGTCTAGTTTCAGGCCGTCGTTTCCGTCCT
CTCGCGAGGTGAATAGGTTTACATC	CGTAAGTCAAACTCAGAGTAAAGAAACATCAACAAGGTTTCCGTCCC
CTCGCGAGGTATATAGGTTTATATC	CGAATGGATTGAAAAAAACTTGGAGAATATCCGATAGTTTCCGTCCC
CTCACGAGGTAAATAGGTTTATATC	TCAATGAAATGAAACAGGACAACGCTTTATAATATGTTTCCATCCC
CTCTTGAGGTATATGGGTTTATATC	AAAACGAAAACCTCTTGATTGAGTTGGAAGAAGCAAAGTTACCGTCCC
CTCTCGAGGTATATAGGTTTATATC	GTAGTCTTGATGATTTGATTAGTTATAAGTCTTTGGGTTTCCGTCCC
CTCTCAAGGTACATAGGTTTATATC	CCATGATAAGAGTGCTTCTACATTAAATCTCGTAATGGGTTACCGTCCC
CTCGCGAGATAAATAGGTTTATATC	TAAAACATTGAAACATGACACGGTGGGGCTATGGGTGTTACCGTCCC
CTCTCGAGGTGAATAGGTTTATATC	TTAAAGGTCATTCTGCACGAATTAGGACGCTCAGATGTTCCGTCTC
CTCTCGAGGTGGATAGGTTTATATC	GCAAAGGAACATTAGCTATCAATCAATCAAAAGATGAGTTTCCGTCCC
CTCGCGAGGTGGATAGGTTTATATC	ACTTCAAGAATTGCAAGAATACGCTTTTAACGTTTTGGTTTCCGTCCC
CTCGCGAGGTAGATAGGGTTATATC	AGTTCGTAAAATATGATGATACATACAAAGAAGAAGCCAGTTACCGTCCC
CTCCCGAGGTAAATAGGGTTATATC	TCCCAGACGATATTCCAGTAAACGAAGGTGACAAGGTGTTTCCGTCCC
CTCGCGAGGCATATAGGTTTATATC	CCTGTGGTTATGACGGAAAAGCCCAACAAGAATTTATGTTACCGTCCC
CTCCCGAGGTATATAGGTTTATATC	ACAGCATTTCCAAGGTTATATAGACGCTGTGGTTGTGGAGTTTCCGTCCC
CTCGCGAGGCATATAGGTTTATATC	TAATGGACGCACAAACAAAAGCAACCAAGAAATGGAAGTTACCGTCCC
CTCACGAGGTGAATAGGTTTGTATC	AGCAGGACTAGACAAGGATACATTCAAGGACAAGTACGGTTTCCGTCCC
CTTGCGAGGTATATAGGTTTATATC	TCAGATTGACGATGAGATATATAGCGATATTTAGTTGTTTCCGTCCA
CTCGCGAGGTATATAGGTTTATACC	AGTAAACAAACTTGTTGAGCTATATGTATCTGAAAATGGTTACCGTCCC
CTCCCGAGGTACATAGGTTTATAGC	GCACCTCTACCTGAAGCGGATGAACCGCAACCTTTGAGTTTCCGTCCC
CTCTCGAGGTGGATAGGTTTATATC	AAGATATTCATTACTACAAGGAATTTGTGGATTGTTACCGTCCC
CTCCCGAGGTACACAGGTTTATATC	GAAAGTAAAAACATTTACAAGGAGATTATATCATGACAGTTACCGTCCC
CTCGCGAGGTGGATAGGTTTATATC	GGGCAACTAATTAGCGTAAGCGGACGACTTCAAAGAGTTATCGTCCC
CTCTCGAGGTATATAGGGTTATATC	GTTAAGAATAAGGAGAAAATAAAATGTTGGGTTGGTTTCCGTCCC
CTCGCGAGGTGAATAGGTTTATATC	CTACTTTGTGAAAGACATGAGAAAAACAGCCTTAGTATGACCGTCCT
CTCTCGAGGTATATAGGTTTATATC	GTAATGACAAAGACACATTTATGATTAAAGGTCTATGGTTACCGTCCC
CTCTCGAGGTAAATAGGTTTATATC	TCGTTGCTTACCACGACGCTGAAAATGCACTTATGGGGTTTCCGTCCC
CTCTCGAGGTGAATAGGTTTATATC	ACTTTCTGATTGGACTTTTGAATTCATTACATTTAGTTTCCGTCCC
CTCTCGAGGTGAATAGGTTTATATC

>NZ_CP018187|2|1|1141602-1141784|PILER-CR
GGTTACCGTCCCCTCTCGAGGTAAATAGGTTTATATCTC	GTTGCTTACCACGACGCTGAAAATGCACTTATGG
GGTTTCCGTCCCCTCTCGAGGTGAATAGGTTTATATCAC	TTTCTGATTGGACTTTTGAATTCATTACATTT
AGTTTCCGTCCCCTCTCGAGGTGAATAGGTTTATATCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018187.1\|WP_156246734.1\|1149424_1150969_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274774
NZ_CP018187.1\|WP_156246724.1\|1134115_1135015_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm4	csm4gr5	COG1567_csm4gr5_CAS-III-A	gnl\|CDD\|380071
NZ_CP018187.1\|WP_156246732.1\|1146115_1146916_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368639
NZ_CP018187.1\|WP_156246736.1\|1152405_1153374_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238560
NZ_CP018187.1\|WP_156246727.1\|1136074_1138375_-\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	cas10	cd09680_cas10_CAS-III	gnl\|CDD\|187811
NZ_CP018187.1\|WP_156246729.1\|1141882_1142212_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CP018187.1\|WP_156246720.1\|1129681_1130377_-\|orotidine-5'-phosphate-decarboxylase	unknown	unknown	gnl\|CDD\|234695
NZ_CP018187.1\|WP_156246733.1\|1147592_1149251_+\|DUF814-domain-containing-protein	unknown	unknown	gnl\|CDD\|336217
NZ_CP018187.1\|WP_156246725.1\|1135016_1135679_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|187815
NZ_CP018187.1\|WP_156246723.1\|1133036_1134113_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	csm5gr7	cd09662_csm5gr7_CAS-III-A	gnl\|CDD\|224251
NZ_CP018187.1\|WP_156246730.1\|1143355_1144312_-\|dihydroorotate-dehydrogenase	unknown	unknown	gnl\|CDD\|235982
NZ_CP018187.1\|WP_004182503.1\|1128964_1129594_-\|orotate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234771
NZ_CP018187.1\|WP_156247084.1\|1144321_1145125_-\|dihydroorotate-dehydrogenase-electron-transfer-subunit	unknown	unknown	gnl\|CDD\|234601
NZ_CP018187.1\|WP_156246731.1\|1145434_1145983_-\|DJ-1-family-protein	unknown	unknown	gnl\|CDD\|153229
NZ_CP018187.1\|WP_156246735.1\|1151019_1152360_+\|MATE-family-efflux-transporter	unknown	unknown	gnl\|CDD\|240543
NZ_CP018187.1\|WP_156246726.1\|1135678_1136071_-\|type-III-A-CRISPR-associated-protein-Csm2	csm2gr11	cd09647_csm2gr11_CAS-III-A	gnl\|CDD\|367635
NZ_CP018187.1\|WP_156246722.1\|1131879_1133040_-\|type-III-A-CRISPR-associated-protein-Csm6	csm6	cd09699_csm6_CAS-III-A	gnl\|CDD\|187830
NZ_CP018187.1\|WP_156246721.1\|1130578_1131865_-\|type-III-A-CRISPR-associated-protein-Csm6	csm6	cd09699_csm6_CAS-III-A	gnl\|CDD\|187830
NZ_CP018187.1\|WP_156246728.1\|1138355_1139087_-\|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NZ_CP018187.1\|WP_156246737.1\|1155042_1157757_+\|restriction-endonuclease-subunit-R	unknown	unknown	gnl\|CDD\|223989

Protein	Function_ID	Function_description	E-value
NZ_CP018187.1\|WP_156246734.1\|1149424_1150969_+\|hypothetical-protein	gnl\|CDD\|274774	TIGR03766, hypothetical_protein_lp_2141, conserved hypothetical integral membrane protein. Models TIGR03110, TIGR03111, and TIGR03112 describe a three-gene system found in several Gram-positive bacteria, where TIGR03110 (XrtG) is distantly related to a putative transpeptidase, exosortase (TIGR02602). This model describes a small clade that correlates by both gene clustering and phyletic pattern, although imperfectly, to the three gene system. Both this narrow clade, and the larger set of full-length homologous integral membrane proteins, have an especially well-conserved region near the C-terminus with an invariant tyrosine. The function is unknown.	4.22035e-15
NZ_CP018187.1\|WP_156246724.1\|1134115_1135015_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm4	gnl\|CDD\|380071	pfam17953, Csm4_C, CRISPR Csm4 C-terminal domain. Clustered, regularly interspaced, short palindromic repeat (CRISPR) loci play a pivotal role in the prokaryotic host defense system against invading genetic materials. The CRISPR loci are transcribed to produce CRISPR RNAs (crRNAs), which form interference complexes with CRISPR-associated (Cas) proteins to target the invading nucleic acid for degradation. The interference complex of the type III-A CRISPR-Cas system is composed of five Cas proteins (Csm1-Csm5) and a crRNA, and targets invading DNA. This entry represents the C-terminal domain found in Csm4. Csm4 structurally resembles Cmr3, a component of the type III-B CRISPR-Cas interference complex. Studies indicate that Csm3-Csm4 complex binds single-stranded RNA in a non-sequence-specific manner. Structural analysis show, Csm3 and Csm4 have one and two ferredoxin-like folds (also known as an RRM-like fold), respectively. The long beta-hairpin inserted into the C-terminal ferredoxin-like fold of Csm4, is well-conserved in the Cmr3 structure. The corresponding beta-hairpin of Cmr3 binds the D1 domain of Cmr2, as observed in the Cmr2-Cmr3 complex structure. Furthermore, it is suggested that the hairpin of Csm4 is responsible for the interaction with Csm1 (ortholog of Cmr2).	6.60439e-38
NZ_CP018187.1\|WP_156246732.1\|1146115_1146916_-\|hypothetical-protein	gnl\|CDD\|368639	pfam05857, TraX, TraX protein. This family consists of several bacterial TraX proteins. TraX is responsible for the amino-terminal acetylation of F-pilin subunits.	1.05715e-13
NZ_CP018187.1\|WP_156246736.1\|1152405_1153374_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238560	cd01140, FatB, Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind their ligands in the cleft between these domains.	1.76113e-44
NZ_CP018187.1\|WP_156246727.1\|1136074_1138375_-\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	gnl\|CDD\|187811	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; signature gene for type III; also known as Csm1 family.	0
NZ_CP018187.1\|WP_156246729.1\|1141882_1142212_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	7.17004e-19
NZ_CP018187.1\|WP_156246720.1\|1129681_1130377_-\|orotidine-5'-phosphate-decarboxylase	gnl\|CDD\|234695	PRK00230, PRK00230, orotidine-5'-phosphate decarboxylase.	8.72742e-138
NZ_CP018187.1\|WP_156246733.1\|1147592_1149251_+\|DUF814-domain-containing-protein	gnl\|CDD\|336217	pfam05833, FbpA, Fibronectin-binding protein A N-terminus (FbpA). This family consists of the N-terminal region of the prokaryotic fibronectin-binding protein. Fibronectin binding is considered to be an important virulence factor in streptococcal infections. Fibronectin is a dimeric glycoprotein that is present in a soluble form in plasma and extracellular fluids; it is also present in a fibrillar form on cell surfaces. Both the soluble and cellular forms of fibronectin may be incorporated into the extracellular tissue matrix. While fibronectin has critical roles in eukaryotic cellular processes, such as adhesion, migration and differentiation, it is also a substrate for the attachment of bacteria. The binding of pathogenic Streptococcus pyogenes and Staphylococcus aureus to epithelial cells via fibronectin facilitates their internalisation and systemic spread within the host.	0
NZ_CP018187.1\|WP_156246725.1\|1135016_1135679_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	gnl\|CDD\|187815	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	5.33711e-84
NZ_CP018187.1\|WP_156246723.1\|1133036_1134113_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	gnl\|CDD\|224251	COG1332, COG1332, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	7.64444e-24
NZ_CP018187.1\|WP_156246730.1\|1143355_1144312_-\|dihydroorotate-dehydrogenase	gnl\|CDD\|235982	PRK07259, PRK07259, dihydroorotate dehydrogenase.	2.618e-170
NZ_CP018187.1\|WP_004182503.1\|1128964_1129594_-\|orotate-phosphoribosyltransferase	gnl\|CDD\|234771	PRK00455, pyrE, orotate phosphoribosyltransferase; Validated.	1.90168e-79
NZ_CP018187.1\|WP_156247084.1\|1144321_1145125_-\|dihydroorotate-dehydrogenase-electron-transfer-subunit	gnl\|CDD\|234601	PRK00054, PRK00054, dihydroorotate dehydrogenase electron transfer subunit; Reviewed.	7.18511e-124
NZ_CP018187.1\|WP_156246731.1\|1145434_1145983_-\|DJ-1-family-protein	gnl\|CDD\|153229	cd03135, GATase1_DJ-1, Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1. Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1. DJ-1 is involved in multiple physiological processes including cancer, Parkinson's disease and male fertility. It is unclear how DJ-1 functions in these. DJ-1 has been shown to possess chaperone activity. DJ-1 is preferentially expressed in the testis and moderately in other tissues; it is induced together with genes involved in oxidative stress response. The Drosophila homologue (DJ-1A) plays an essential role in oxidative stress response and neuronal maintenance. Inhibition of DJ-1A function through RNAi, results in the cellular accumulation of reactive oxygen species, organismal hypersensitivity to oxidative stress, and dysfunction and degeneration of dopaminergic and photoreceptor neurons. DJ-1 has lacks enzymatic activity and the catalytic triad of typical GATase1 domains, however it does contain the highly conserved cysteine located at the nucelophile elbow region typical of these domains. This cysteine been proposed to be a site of regulation of DJ-1 activity by oxidation. DJ-1 is a dimeric enzyme.	1.25976e-71
NZ_CP018187.1\|WP_156246735.1\|1151019_1152360_+\|MATE-family-efflux-transporter	gnl\|CDD\|240543	cd13138, MATE_yoeA_like, Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.	1.88007e-115
NZ_CP018187.1\|WP_156246726.1\|1135678_1136071_-\|type-III-A-CRISPR-associated-protein-Csm2	gnl\|CDD\|367635	pfam03750, Csm2_III-A, Csm2 Type III-A. Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-associated) proteins. This entry represents Csm2 Type III-A, a family of Cas proteins also known as TM1810/Csm2.	4.26507e-21
NZ_CP018187.1\|WP_156246722.1\|1131879_1133040_-\|type-III-A-CRISPR-associated-protein-Csm6	gnl\|CDD\|187830	cd09699, Csm6_III-A, CRISPR/Cas system-associated protein Csm6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; loosely associated with CRISPR/Cas systems.	2.2674e-84
NZ_CP018187.1\|WP_156246721.1\|1130578_1131865_-\|type-III-A-CRISPR-associated-protein-Csm6	gnl\|CDD\|187830	cd09699, Csm6_III-A, CRISPR/Cas system-associated protein Csm6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; loosely associated with CRISPR/Cas systems.	5.23518e-118
NZ_CP018187.1\|WP_156246728.1\|1138355_1139087_-\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	2.66414e-20
NZ_CP018187.1\|WP_156246737.1\|1155042_1157757_+\|restriction-endonuclease-subunit-R	gnl\|CDD\|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	2.82111e-31

>NZ_CP018187.1|WP_156246728.1|1138355_1139087_-|CRISPR-associated-endoribonuclease-Cas6
MKKLVFTFKRIDHPAQDLAVKFHGFLMEQLDSDYVDYLHQQQTNPYATKVIQGKENTQWVVHLLTDDLEDKVFMTLLQIKEVSLNDLPKLSVEKVEIQELGADKLLEIFNSEDNQTYFSIIFETSTGFKSQGSYVIFPSMRLIFQSLMQKYGRLVENQPEIEEDTLDYLSEHSTITNYRLETSYFRVHGQRIPAFRGRLTFKVQGAQTLKAYVKMLLTFGEYLGLGMKTSLGMGGIKLEERKD
>NZ_CP018187.1|WP_156246727.1|1136074_1138375_-|type-III-A-CRISPR-associated-protein-Cas10/Csm1
MKKEKIDLFYGALLHDIGKVIQRATGERKKHALVGADWFDEIVDNQVISDQIRYHMANYQSDKLSNDHLAYITYIADNIASGVDRRQSNEESDEDASAKIWDTYTNQADIFNVFGAQTDKRYFKPTVLNLKSEPNFASATYEPFSKGDYAAIATRIKNELAEFEFNQAQIDSLLNLFEATLSFVPSSTNTKEIADISLAEHSRLTAAFALAIYDYLEDKGRHNYKEDLFTKASAFYEEEAFLLASFDLSGIQDFIYNIATSGAAKQLKARSLYLDFMSEYIADSLLDKLGLNRANLLYVGGGHAYFVLANTEKTVETLVQFEKDFNQFLLANFQTRLYVAFGWGSFAAKDIMSELNSPESYRQVYQKASRMISEKKISRYDYQTLMLLNRGGKSSERECEICHSVENLVDSKNLVDSKKKNQKVCVICQGLYCFSKEIAHNHFIITKNKGLPIGPNACLKGIAFEKLRHEEFSRVYVKNDYKAGTVKATHVFVGDYQHTTIDKYADLSKNENKLGIKRLAVVRLDVDDLGAAFMAGFSQQGNGQYSTLSRSATFSRSMSLFFKVYINQFASDKKLSIIYAGGDDVFAIGSWQDIIAFTVELRQNFIKWTNGKLTLSAGIGLFADKTPISLMAHQTGELEEAAKGNEKDSISLFSSDYTFKFDQFITNVYDDKLEQIRYFFNHQDERGKNFIYKLIELLRNYESEEKMNVARLAYYLTRLEELTDKEERDKFKQFKKLFFKWYTNNESDRKEAELALLLYVYEIRKD
>NZ_CP018187.1|WP_156246726.1|1135678_1136071_-|type-III-A-CRISPR-associated-protein-Csm2
MAILTDENYVDKAERAISLLEKDNKGNYLLTTSQIRNLLSLCSSLYDRSKERKFDELINDVSYLRVQFVYQSGRNSVRVNRQTFFPVKDLVEKGQILEALKEVKDRETLQRFCRYMEALVAYFKFYGGKD
>NZ_CP018187.1|WP_156246725.1|1135016_1135679_-|type-III-A-CRISPR-associated-RAMP-protein-Csm3
MTFAKIKFSAQIRLETGLHIGASNAFAAIGAIDSPVIKDPITNLPIIPGSSLKGKMRTLLAKVYNEKVAEKPSDDSDVLSRLFGNSEDKRFKMGRLIFRDAFLSNTDELDSLGARSYTEVKFENTIDRITAEANPRQIERAIRNSTFDFELIYEITDKNENQVEEDFKVIRDGLKLLELDYLGGSGSRGYGKVAFENLKATTVFGNYDVKPLNELLTAEV
>NZ_CP018187.1|WP_156246724.1|1134115_1135015_-|type-III-A-CRISPR-associated-RAMP-protein-Csm4
MTYKMYIMTFQNAHFGSGTLDSSKLTFSADRIFSALVLEALKMGKLDAFLAEANQDDFTLTDAFPFQFGPFLPKPIGYPKHDQIDQSVDVKEVRRQAKLSKKLQFLALENVDDYLNGDLFENEEHAVIDTVTKNQPHKDGNLYQVATTRFSNDTSLYVIANESDLLNELMTSLQYSGLGGKRSSGYGRFELDIQNIPLELSDRLTKNHSDKVMSLTTALPVDADLEEAMEDGHYLLTKSSGFAFSHATNENYRKQDLYKFASGSTFSKTFEGQIVDVRPLDFPHAVLNYAKPLFFKLEV
>NZ_CP018187.1|WP_156246723.1|1133036_1134113_-|type-III-A-CRISPR-associated-RAMP-protein-Csm5
MKNDYRTFKLSLLTLAPIHIGNGEKYTSREFIYENKKFYFPDMGKFYNQMVEKRLAEKFEAFLIQTRPNARNNRLISFLNDNRIAERSFGGYSISETGLESDRNPNSAGAINEVNKFIRDAFGNPYIPGSSLKGAIRTILMNTTPKWNNENAVNDFGRFPRENKNLIPWGPKKGKEYDDLFNAIRVSDSKPFDNKRLILVQKWDYSAKTNKAKPLPLYRESVSPFTKIEFEITTTTNEAGQLIEELGKRAQTFYKAYKAFFLSEFPDDMIQTNLQYPIYLGAGTGAWTKTLFKQADGILQRRYSRMTTTKMVKKGVLKLTKAPLKTVKIPSGDHSLIKNDKSFYEMGKANFLIKEIDK
>NZ_CP018187.1|WP_156246722.1|1131879_1133040_-|type-III-A-CRISPR-associated-protein-Csm6
MRVLISAVGDTDPFRNFHDGALIHIARKYRPEKVVLIFSEHTAKKQGNIEKALFSIAPNYEPELIIHDSIISDNEVHIFDVMFQRFSDILQKYYTKDDEFILNLSSATPQIKSALFVINRLNGINVRAVQVSSPEHASNENIGHDNDEDIDELIEVNEDNKVDFIDRTIEDNAEKFSQALLKKTARDFIEKFDYKAALDILDQLSDFQDLKDVREEIRDIVKCLSKQDVPKGLRHKKFNEAEQKILSAYLTIELQRERGNVSESFIRIKNLTEFILEDYIEKRYPGIIDDYCEDIQKYYLSLFDYSKLLKATREFELRRTIAPIIEMNSSRNKVAHSLSPLDSDAVKQLGIAMKTLKTLVREQYHFSQSDFNFYQDLNKKLLTKLN
>NZ_CP018187.1|WP_156246721.1|1130578_1131865_-|type-III-A-CRISPR-associated-protein-Csm6
MKILISAVGTTDPISNNHDAALLHIARNYRPDKIVLVYSQEMMVKQDLINKVLLSIEGYNPIIEIDSTILNNDEVFLFDKMYEVMGQIVQKYTNDDNEIILNLSSGTPQIISALFALNRINDYNTQAIQVATPKNGANREYTALTDSEIDALIVENQDNSLDFVDRSIKDKSEKFTQALVKRHLRSLIASFDYQAAEAIINRKEYNKLLSKKKIAYIREKLYDFSRVFKNQSILSDILSFPLDDSQKKALNYYLMIDVLKEREHIADVLIKAKSLAEFVIEETIKKDHEGLIVFVGNLPKLNPSFPECEAILDDIDKKMKKSRGIEDTEERIFSVQSTLNLLSYLNILEFYEYDSQLQTAINGILSLNGERNKVAHGLSEIDTRLLSRKKLKQLSENLRLLLVDCLDIDSSYFNYYDKQNEELIKMLE
>NZ_CP018187.1|WP_156246720.1|1129681_1130377_-|orotidine-5'-phosphate-decarboxylase
MRENRPVIALDFPTFEDVKAFLAKFPADEKLYVKIGMELYYAAGPEIVRYVKDLGHSVFLDLKLHDIPNTVKSAMRVLSNLGVDMTNVHAAGGVEMMKAAREGLGDGPILIAVTQLTSTSEEQMRDFQNIQTTLQESVVHYAKKTAEAGLDGVVCSAHEVAKIKEATNEGFVCLTPGIRPAGAAVGDQKRVMTPADARQIGSDYIVVGRPITQADDPVAAYHDIKAQWIGQ
>NZ_CP018187.1|WP_004182503.1|1128964_1129594_-|orotate-phosphoribosyltransferase
MTLASQIASDLLDIKAVYLKPEEPFTWASGIKSPIYTDNRITLSYPETRTLIENGFVEKIKEEFPEVEVIAGTATAGIPHGAIIADKMNLPFAYIRSKPKDHGAGNQIEGRVVKGEKMVVVEDLISTGGSVLDAVAAAEREGADVIGVVAIFTYELPKAEKNFADAGVKLVTLSNYTELIKVAKVQGYITADGLQLLKKFKENQETWQD
>NZ_CP018187.1|WP_156246729.1|1141882_1142212_-|CRISPR-associated-endonuclease-Cas2
MGLYFNLSEEEREFARQRTMFCLIIYDIRSNKRRLKHSKLLEGYGVRVQKSCFEVDLSRNDYQSLLKDIESFYKADEEDSIIVYVTTKEEVTSFSPYNSAEKLDDILFF
>NZ_CP018187.1|WP_156246730.1|1143355_1144312_-|dihydroorotate-dehydrogenase
MSETKSENRLAISLPGLDLKNPIIPASGCFGFGQEYAKYYDLDKLGSIMIKATTATPRFGNPTPRVAETPSGMLNAIGLQNPGVDAVLTEKLPWLQEHYPELPIIANVAGFSNEEYAEVSHKISKANNVKAIELNISCPNVDHGNNGLLIGQVPELAYAAVKASVSHSDVPVYVKLTPSVADITSVAKAVEDAGATGFTMINTLVGTRYDLATRKPIIANGQGGMSGPAVFPVALKLIRQVALASDLPIIGMGGVDSAEAAIEMFIAGASAIGVGTANFADPYACPKIIDRLPEVMDKYGITTLEDLRKEVRTELLGK
>NZ_CP018187.1|WP_156247084.1|1144321_1145125_-|dihydroorotate-dehydrogenase-electron-transfer-subunit
MTFCSLERVVMILVEDLTIVSQREIAPRIFEMVLKGEMVADMQVGQFVHLKVPDPSKLLRRPISISEIDYDKKEATIVYRVEREGTAILSKMVVGQTIDTMGPQGNGFDISVVEAGQRALLVGGGIGVPPLVETAKQLKAKGVEVVSVIGFANKDAVILEDKLRACGDVYVTTDDGSYGIKGYVSTVIDGFDWTPDAVYSCGAPGMLKYVDSKFENHPHAYVSMEARMACGMGACYACVVHVKGESDAKNLRVCEEGPVFPTGKVVV
>NZ_CP018187.1|WP_156246731.1|1145434_1145983_-|DJ-1-family-protein
MTKVAVVFADGFEEIEALSPVDVFRRAGFDCSMLGLENASVTGSHGIQVAMDGVFDGNFADYDLVVLPGGMPGSTNLRDNETLIASLQEAAKAGKYVAAICAAPIVLERAGLLEGRKFTCFPGVEEQIASGEHQTDLVVVDGNIVTSRGAGTALAFAYALVDLLGGDGQQLAHTMVYDRLFK
>NZ_CP018187.1|WP_156246732.1|1146115_1146916_-|hypothetical-protein
MNDIKKICNATNLKYLAVALMFLDQIYQMFGSMWAPIWLTMLGRLAFPIFLFLAADSFHYTHDRMAFLRRLLYMSWFMTIGNAIIGSIFHNGSIGLTNNAFSTFFITGIFICSWDLLAKGLRDKSNKGLIQGIGVFLLPILSSIPVVVLAGIFETPHANPLLVQIVAFILSLVPSIIMVEGGFVMVILGLLFYIFRTNRIAQIIVLAVISVIAHLFDPTGVQWMMVFAAIPMYFYNGERGSGNKNFFYIFYPAHIYLLWILASLFR
>NZ_CP018187.1|WP_156246733.1|1147592_1149251_+|DUF814-domain-containing-protein
MSFDGFFLHHMTAELREQVLYGRIQKVNQPFERELVLTIRNNRQNYKLLLSAHPVFGRIQTTKAELPNPQNPNTYTMIMRKYLQGAVIEDIQQVENDRVLEISVSNKNEIGDSVKVTLVMEIMGKHSNIILIDKNESKIIESIKHVGFSQNSYRTILPGSTYIAPPKTDAKNPFDIADEKLFEILQTEDLSARNLQKLFQGLGRDTANELSALLETDKLKNFRAFFNREVEPNLTAKAFSAVRFSDSQDQPEFETLSALLDYYYLDKAARDRVAQQASDLIHRVQNELEKNKKKLVKQEKELAATENAEEFRQKGELLTTYLSIVPNDKDSVELDNYYTGEKITIPLNVALTPNQNAQRYFKKYQKLKEAVKHLTGLIEETKQTIDYLESVEFSLSQANMDEIEDIREELVQAGFMKRRSTDKRHKRKKPEQYLASDGKTIIMVGRNNLQNEELTFKMAKKGELWFHAKDIPGSHVVIKDNLNPTDEVKTDAAELAAYYSKARLSNLVQVDMIDVKKLNKPTAGKPGFVTYTGQKTLRVTPTEEKIDSMRMK
>NZ_CP018187.1|WP_156246734.1|1149424_1150969_+|hypothetical-protein
MKALMSYTSSVLEWLGRYVGLLVFGILFVTALLIRTTMMTGYFEWAEISSVPWYVYVSGGVILLLTLLWRKILKELTTKQIFIFFSVCFMIFGLLLIFLTSFAGRDDAGTVFKGAVQFNAGNFSLIKPGAYFYRYPHQLGLLSFERLVLYLIPLPVISVFYVLNLGMVIGMNYATWKITDELFTKPLVSRLAVIMSFGFLPLVFNIMFAYGLMYGLFFSSFAILFFLRYLRHGKVRNAIVSVVMLSLAYWVRSNNIILIIALSGILILMTLREKRYRYLLLVLAFFAFPMTLHKATTSYYEITTHQKIPGTPQIAWLAMGLQDKPDSKRMPGWYTGYVRDIYAKKKGNIEKIEKSANHLFDKRVQYLLAHPDEASWFFRTKFISSWTEGSFQSIWNGPSKDKFQPLWNRFATSIYHDGTLHLFFVTYMQGYLLVLYLGGAFYYAFTYKRMGDGATLGLYAFLYLFGGILFHLISETKSQYTLPYIYLQIPMIAAGYNHMTQILSRYLKNMRKSS
>NZ_CP018187.1|WP_156246735.1|1151019_1152360_+|MATE-family-efflux-transporter
MKNSSVDLLRGPILRSLLIFALPILISNIFQQLYNTADVMIVGRFLGPDALAAVGASSAIFDLVIGFALSVGNGMGVVIARYYGAQDYRKLRQSVAATVVIGLGLSALVMILGHFGLYPLLRFLGTPASIIGQSYQYISMIVSCVGVTLGYNLCAGLLRAVGDSLTALYFLIFSALVNIVLDLFFITQLHLGVQSAGLATIISQGLSAILCLYYIKKKVTFLLPRKSDFVLDSSLYLDLFGQGMAMGLMNSIVSIGTVTLQYAINGFGPLIISAQVAARRIMSFAVLPLTSLAAGVTTFTSQNFGAKQFKRIVAGLKQSCLVSITWSVIACVLLYVASPFLAGLISGSENAVIIDNASRYLRISSLFYPILGMLFIFRNSLQGLGKKLTPLTSSFIELFGKILFVLLVIPSMGYLGVILCEPLIWIPMTIQLYFALRKHVKRLFVS
>NZ_CP018187.1|WP_156246736.1|1152405_1153374_-|ABC-transporter-substrate-binding-protein
MKKINLLYLLAILAIISGLLLYYLPDMTSGHSAESNQTSQSFKEKMIVHDFGTTELKKAPKRIVILDNLYGEILDPLDITPVGATTGQADSQEFSTLFKKQYKDAKVVSVGWQGNPDLDKIAELKPDLILMTGEQEDLYEELSEIAPTVGYQINTDENWDYHETSLKVAEIFDKRDEMKKDLDRLDAREAVFAENVKAKFGDQKLMYLRVTDNDIRYYAYGHFGYLYDTYHFNRAETFNPDDMFQVIDPDKLKDINPDLLIVQADSQELLDNKLKNTPVWTSLKAVQNNKVIYADYSTYMLGFGIVSQEAIMKQISDEWGLN
>NZ_CP018187.1|WP_156246737.1|1155042_1157757_+|restriction-endonuclease-subunit-R
MLDQLSFKGQWRQYQQRVLDKSESFMDDGKIHLVAAPGSGKTTLGIEFIRRFGNPTLILVPTVTIRQQWVDRIKQAFLSDANQAEQLISQDLKRPKMITVATYQALHSAMNQVVGDGLIEDTDDTAQQEHFNFQDFDIRKTFEDKDLGTLCLDECHHLRNEWWKSLEIFRKSFPKIKMISLTATPPYEGEPALWERYISMCGEIDEEITVPELVKEGTLCPHQDYVYFAFPTKEERAQLDQFDKQKLNFLSKLSRDINFSNTIQSSPALSGQIGYDDLLANPKYLSATLIFLRSKELPFPQRFQELLSAKTLPTFTLEWFETLLNGVIFQVPNWYGFTEEAFNQLKSDLKANGLIERNQVKLIRNKKQDVLLNQSLGKLNAIRDIFKAEYQSLGNNLRQLVLTDFIRKDFQIHLGDNSAQFTQLGVLSYFESIRREMIEQSWTVPVAVLTGSIVIIPTSAKEHLERLIPNSRLSYDVIGQLSQEDYLKVSVSGSHHDLVTTLTQLFQEGHIQVIIGTKSLLGEGWDAPCVNSLILASFVGSFMLSNQMRGRAIRVCPDNPNKTSNIWHLVSINLSPRRWFDFQDEKEKYDETLELQLYVLSPDLDLLDRRMTQFLGLHYQEPTIESGIDRLDLNQITFSRKGLEKLNQNAITLSQKRQELKDRWQQALPLYEEMEVVNQVEVDKQFLPLVYLNDWMKAFLISQALAATFFIIDLGRYLIVGKPFDQSLPIFLLALLVLAIFWGRYFIYKSPYKRLEIFGKAIHQALLDSGQIETKESAPRVVKDSKQAIYNAIYLKGASMREKEIFAQTMTEFFAPIENQRYILKACHKVKDQTEFFAVPSMFEKRKADAESFLRHIQKSLGKYDLIYTRSVQGRPILLEARIKALGNKQERTVTHKKVMSTLE

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP018187_2	2.63\|1141209\|44\|NZ_CP018187\|CRISPRCasFinder	1141209-1141252	44	NZ_CP020429	Streptococcus sp. FDAARGOS_192 plasmid unnamed1, complete sequence	103451-103494	4	0.909
NZ_CP018187_2	2.63\|1141209\|44\|NZ_CP018187\|CRISPRCasFinder	1141209-1141252	44	NZ_CP018188	Streptococcus salivarius strain ICDC2 plasmid, complete sequence	111535-111578	4	0.909
NZ_CP018187_2	2.63\|1141209\|44\|NZ_CP018187\|CRISPRCasFinder	1141209-1141252	44	NZ_CP020439	Streptococcus equinus strain FDAARGOS_251 plasmid unamed1 sequence	131119-131162	4	0.909
NZ_CP018187_2	2.63\|1141209\|44\|NZ_CP018187\|CRISPRCasFinder	1141209-1141252	44	NZ_CP040803	Streptococcus salivarius strain LAB813 plasmid pSAL813, complete sequence	75518-75561	5	0.886
NZ_CP018187_2	2.63\|1141209\|44\|NZ_CP018187\|CRISPRCasFinder	1141209-1141252	44	MN480763	Streptococcus salivarius strain YU10 plasmid pSsal-YU10, complete sequence	122475-122518	5	0.886
NZ_CP018187_2	2.63\|1141209\|44\|NZ_CP018187\|CRISPRCasFinder	1141209-1141252	44	MN480762	Streptococcus salivarius strain NU10 plasmid pSsal-NU10, complete sequence	16343-16386	5	0.886
NZ_CP018187_2	2.62\|1141136\|48\|NZ_CP018187\|CRISPRCasFinder	1141136-1141183	48	NZ_CP018188	Streptococcus salivarius strain ICDC2 plasmid, complete sequence	176485-176532	6	0.875
NZ_CP018187_2	2.62\|1141136\|48\|NZ_CP018187\|CRISPRCasFinder	1141136-1141183	48	MN480762	Streptococcus salivarius strain NU10 plasmid pSsal-NU10, complete sequence	127530-127577	7	0.854
NZ_CP018187_2	2.62\|1141136\|48\|NZ_CP018187\|CRISPRCasFinder	1141136-1141183	48	MN480763	Streptococcus salivarius strain YU10 plasmid pSsal-YU10, complete sequence	35856-35903	7	0.854
NZ_CP018187_2	2.27\|1141121\|52\|NZ_CP018187\|CRT	1141121-1141172	52	NZ_CP018188	Streptococcus salivarius strain ICDC2 plasmid, complete sequence	176470-176521	9	0.827
NZ_CP018187_2	2.28\|1141194\|48\|NZ_CP018187\|CRT	1141194-1141241	48	NZ_CP020439	Streptococcus equinus strain FDAARGOS_251 plasmid unamed1 sequence	131130-131177	9	0.812
NZ_CP018187_2	2.28\|1141194\|48\|NZ_CP018187\|CRT	1141194-1141241	48	NZ_CP020429	Streptococcus sp. FDAARGOS_192 plasmid unnamed1, complete sequence	103436-103483	9	0.812
NZ_CP018187_2	2.28\|1141194\|48\|NZ_CP018187\|CRT	1141194-1141241	48	NZ_CP018188	Streptococcus salivarius strain ICDC2 plasmid, complete sequence	111520-111567	9	0.812
NZ_CP018187_2	2.28\|1141194\|48\|NZ_CP018187\|CRT	1141194-1141241	48	MN480762	Streptococcus salivarius strain NU10 plasmid pSsal-NU10, complete sequence	16354-16401	9	0.812
NZ_CP018187_2	2.47\|1140039\|48\|NZ_CP018187\|CRISPRCasFinder	1140039-1140086	48	NC_018285	Streptococcus phage YMC-2011, complete genome	11078-11125	9	0.812
NZ_CP018187_2	2.12\|1140024\|52\|NZ_CP018187\|CRT	1140024-1140075	52	NC_018285	Streptococcus phage YMC-2011, complete genome	11063-11114	10	0.808
NZ_CP018187_2	2.27\|1141121\|52\|NZ_CP018187\|CRT	1141121-1141172	52	MN480762	Streptococcus salivarius strain NU10 plasmid pSsal-NU10, complete sequence	127541-127592	10	0.808
NZ_CP018187_2	2.27\|1141121\|52\|NZ_CP018187\|CRT	1141121-1141172	52	MN480763	Streptococcus salivarius strain YU10 plasmid pSsal-YU10, complete sequence	35841-35892	10	0.808
NZ_CP018187_2	2.45\|1139896\|47\|NZ_CP018187\|CRISPRCasFinder	1139896-1139942	47	MH892354	Streptococcus phage SW3, complete genome	23724-23770	10	0.787
NZ_CP018187_2	2.47\|1140039\|48\|NZ_CP018187\|CRISPRCasFinder	1140039-1140086	48	MF417874	Uncultured Caudovirales phage clone 3S_14, partial genome	12267-12314	10	0.792
NZ_CP018187_2	2.53\|1140474\|48\|NZ_CP018187\|CRISPRCasFinder	1140474-1140521	48	FJ965538	Streptococcus phage 5093, complete genome	31281-31328	10	0.792
NZ_CP018187_2	2.54\|1140547\|50\|NZ_CP018187\|CRISPRCasFinder	1140547-1140596	50	NZ_CP020439	Streptococcus equinus strain FDAARGOS_251 plasmid unamed1 sequence	170569-170618	10	0.8
NZ_CP018187_2	2.54\|1140547\|50\|NZ_CP018187\|CRISPRCasFinder	1140547-1140596	50	NZ_CP020430	Streptococcus sp. FDAARGOS_192 plasmid unnamed2 sequence	4964-5013	10	0.8
NZ_CP018187_2	2.54\|1140547\|50\|NZ_CP018187\|CRISPRCasFinder	1140547-1140596	50	NZ_CP020430	Streptococcus sp. FDAARGOS_192 plasmid unnamed2 sequence	15526-15575	10	0.8
NZ_CP018187_2	2.54\|1140547\|50\|NZ_CP018187\|CRISPRCasFinder	1140547-1140596	50	NZ_CP020429	Streptococcus sp. FDAARGOS_192 plasmid unnamed1, complete sequence	48501-48550	10	0.8
NZ_CP018187_2	2.54\|1140547\|50\|NZ_CP018187\|CRISPRCasFinder	1140547-1140596	50	MN480763	Streptococcus salivarius strain YU10 plasmid pSsal-YU10, complete sequence	71068-71117	10	0.8
NZ_CP018187_2	2.58\|1140843\|48\|NZ_CP018187\|CRISPRCasFinder	1140843-1140890	48	NC_018285	Streptococcus phage YMC-2011, complete genome	7208-7255	10	0.792
NZ_CP018187_2	2.59\|1140916\|49\|NZ_CP018187\|CRISPRCasFinder	1140916-1140964	49	MF417874	Uncultured Caudovirales phage clone 3S_14, partial genome	6912-6960	10	0.796
NZ_CP018187_2	2.5\|1139526\|51\|NZ_CP018187\|CRT	1139526-1139576	51	CP029253	Streptococcus phage VS-2018a, complete genome	39394-39444	11	0.784
NZ_CP018187_2	2.5\|1139526\|51\|NZ_CP018187\|CRT	1139526-1139576	51	NC_022776	Streptococcus phage TP-778L complete genome	41327-41377	11	0.784
NZ_CP018187_2	2.28\|1141194\|48\|NZ_CP018187\|CRT	1141194-1141241	48	NZ_CP040803	Streptococcus salivarius strain LAB813 plasmid pSAL813, complete sequence	75503-75550	11	0.771
NZ_CP018187_2	2.28\|1141194\|48\|NZ_CP018187\|CRT	1141194-1141241	48	MN480763	Streptococcus salivarius strain YU10 plasmid pSsal-YU10, complete sequence	122460-122507	11	0.771
NZ_CP018187_2	2.40\|1139541\|47\|NZ_CP018187\|CRISPRCasFinder	1139541-1139587	47	CP029253	Streptococcus phage VS-2018a, complete genome	39409-39455	11	0.766
NZ_CP018187_2	2.40\|1139541\|47\|NZ_CP018187\|CRISPRCasFinder	1139541-1139587	47	NC_022776	Streptococcus phage TP-778L complete genome	41342-41388	11	0.766
NZ_CP018187_2	2.53\|1140474\|48\|NZ_CP018187\|CRISPRCasFinder	1140474-1140521	48	KY705259	Streptococcus phage P5641, complete genome	24239-24286	11	0.771
NZ_CP018187_2	2.53\|1140474\|48\|NZ_CP018187\|CRISPRCasFinder	1140474-1140521	48	MH937461	Streptococcus phage CHPC642, complete genome	23647-23694	11	0.771
NZ_CP018187_2	2.53\|1140474\|48\|NZ_CP018187\|CRISPRCasFinder	1140474-1140521	48	MG708274	Streptococcus phage vB_SthS_VA214, complete genome	11699-11746	11	0.771
NZ_CP018187_2	2.53\|1140474\|48\|NZ_CP018187\|CRISPRCasFinder	1140474-1140521	48	HG424323	Streptococcus phage 20617 complete prophage genome	42708-42755	11	0.771
NZ_CP018187_2	2.53\|1140474\|48\|NZ_CP018187\|CRISPRCasFinder	1140474-1140521	48	AF020798	Streptococcus thermophilus bacteriophage lysogeny module, integrase homolog (int), putative host cell surface-exposed lipoprotein, putative metallo-proteinase, repressor, Cro-like regulatory protein, and P1-antirepressor homolog genes, complete cds	1662-1709	11	0.771
NZ_CP018187_2	2.53\|1140474\|48\|NZ_CP018187\|CRISPRCasFinder	1140474-1140521	48	NC_000871	Streptococcus phage Sfi19, complete genome	25907-25954	11	0.771
NZ_CP018187_2	2.53\|1140474\|48\|NZ_CP018187\|CRISPRCasFinder	1140474-1140521	48	AF158601	Streptococcus thermophilus bacteriophage SFi18 lysin, gp111, gp183, gp47, gp54, gp71, gp145, gp69, gp40, gp229, gp157, gp233, putative helicase, gp151, gp271, putative primase, gp143, gp106, gp89, gp57, gp51, gp66, gp192, putative DNA binding protein, gp99, and gp235 genes, complete cds	2568-2615	11	0.771
NZ_CP018187_2	2.53\|1140474\|48\|NZ_CP018187\|CRISPRCasFinder	1140474-1140521	48	HE861935	Streptococcus phage TP-J34 complete genome	44511-44558	11	0.771
NZ_CP018187_2	2.53\|1140474\|48\|NZ_CP018187\|CRISPRCasFinder	1140474-1140521	48	AF115102	Streptococcus thermophilus bacteriophage Sfi19, complete genome	25907-25954	11	0.771
NZ_CP018187_2	2.53\|1140474\|48\|NZ_CP018187\|CRISPRCasFinder	1140474-1140521	48	NC_002214	Streptococcus thermophilus bacteriophage Sfi11, complete genome	28287-28334	11	0.771
NZ_CP018187_2	2.53\|1140474\|48\|NZ_CP018187\|CRISPRCasFinder	1140474-1140521	48	MH937469	Streptococcus phage CHPC919, complete genome	24227-24274	11	0.771
NZ_CP018187_2	2.72\|1141714\|32\|NZ_CP018187\|PILER-CR	1141714-1141745	32	NZ_CP032924	Agrobacterium tumefaciens strain 1D1108 plasmid pAt1D1108b, complete sequence	125472-125503	11	0.656
NZ_CP018187_2	2.19\|1140532\|54\|NZ_CP018187\|CRT	1140532-1140585	54	NZ_CP020439	Streptococcus equinus strain FDAARGOS_251 plasmid unamed1 sequence	170554-170607	12	0.778
NZ_CP018187_2	2.19\|1140532\|54\|NZ_CP018187\|CRT	1140532-1140585	54	NZ_CP020430	Streptococcus sp. FDAARGOS_192 plasmid unnamed2 sequence	4949-5002	12	0.778
NZ_CP018187_2	2.19\|1140532\|54\|NZ_CP018187\|CRT	1140532-1140585	54	NZ_CP020430	Streptococcus sp. FDAARGOS_192 plasmid unnamed2 sequence	15537-15590	12	0.778
NZ_CP018187_2	2.19\|1140532\|54\|NZ_CP018187\|CRT	1140532-1140585	54	NZ_CP020429	Streptococcus sp. FDAARGOS_192 plasmid unnamed1, complete sequence	48512-48565	12	0.778
NZ_CP018187_2	2.19\|1140532\|54\|NZ_CP018187\|CRT	1140532-1140585	54	MN480763	Streptococcus salivarius strain YU10 plasmid pSsal-YU10, complete sequence	71079-71132	12	0.778
NZ_CP018187_2	2.45\|1139896\|47\|NZ_CP018187\|CRISPRCasFinder	1139896-1139942	47	MF417874	Uncultured Caudovirales phage clone 3S_14, partial genome	16489-16535	12	0.745
NZ_CP018187_2	2.53\|1140474\|48\|NZ_CP018187\|CRISPRCasFinder	1140474-1140521	48	KY705273	Streptococcus phage P7602, complete genome	24487-24534	12	0.75
NZ_CP018187_2	2.53\|1140474\|48\|NZ_CP018187\|CRISPRCasFinder	1140474-1140521	48	MH937479	Streptococcus phage CHPC952, complete genome	24877-24924	12	0.75
NZ_CP018187_2	2.53\|1140474\|48\|NZ_CP018187\|CRISPRCasFinder	1140474-1140521	48	MK202161	Streptococcus phage CHPC1282, complete genome	22732-22779	12	0.75
NZ_CP018187_2	2.53\|1140474\|48\|NZ_CP018187\|CRISPRCasFinder	1140474-1140521	48	MH937464	Streptococcus phage CHPC869, complete genome	25443-25490	12	0.75
NZ_CP018187_2	2.53\|1140474\|48\|NZ_CP018187\|CRISPRCasFinder	1140474-1140521	48	MH937480	Streptococcus phage CHPC954, complete genome	24612-24659	12	0.75
NZ_CP018187_2	2.53\|1140474\|48\|NZ_CP018187\|CRISPRCasFinder	1140474-1140521	48	MH937475	Streptococcus phage CHPC931, complete genome	24860-24907	12	0.75
NZ_CP018187_2	2.53\|1140474\|48\|NZ_CP018187\|CRISPRCasFinder	1140474-1140521	48	MH937503	Streptococcus phage CHPC1084, complete genome	25000-25047	12	0.75
NZ_CP018187_2	2.53\|1140474\|48\|NZ_CP018187\|CRISPRCasFinder	1140474-1140521	48	MH937505	Streptococcus phage CHPC1109, complete genome	22515-22562	12	0.75
NZ_CP018187_2	2.54\|1140547\|50\|NZ_CP018187\|CRISPRCasFinder	1140547-1140596	50	MN480762	Streptococcus salivarius strain NU10 plasmid pSsal-NU10, complete sequence	55868-55917	12	0.76
NZ_CP018187_2	2.19\|1140532\|54\|NZ_CP018187\|CRT	1140532-1140585	54	NZ_CP015284	Streptococcus salivarius strain ATCC 25975 plasmid, complete sequence	48696-48749	13	0.759
NZ_CP018187_2	2.19\|1140532\|54\|NZ_CP018187\|CRT	1140532-1140585	54	NZ_CP040803	Streptococcus salivarius strain LAB813 plasmid pSAL813, complete sequence	17029-17082	13	0.759
NZ_CP018187_2	2.19\|1140532\|54\|NZ_CP018187\|CRT	1140532-1140585	54	NZ_CP040803	Streptococcus salivarius strain LAB813 plasmid pSAL813, complete sequence	181046-181099	13	0.759
NZ_CP018187_2	2.19\|1140532\|54\|NZ_CP018187\|CRT	1140532-1140585	54	NZ_CP018188	Streptococcus salivarius strain ICDC2 plasmid, complete sequence	67562-67615	13	0.759
NZ_CP018187_2	2.24\|1140901\|53\|NZ_CP018187\|CRT	1140901-1140953	53	MF417874	Uncultured Caudovirales phage clone 3S_14, partial genome	6923-6975	13	0.755
NZ_CP018187_2	2.19\|1140532\|54\|NZ_CP018187\|CRT	1140532-1140585	54	MN480762	Streptococcus salivarius strain NU10 plasmid pSsal-NU10, complete sequence	55853-55906	14	0.741

1. spacer 2.63|1141209|44|NZ_CP018187|CRISPRCasFinder matches to NZ_CP020429 (Streptococcus sp. FDAARGOS_192 plasmid unnamed1, complete sequence) position: , mismatch: 4, identity: 0.909

aagatattcattactacaaggaatttgtgga-ttgttaccgtccc	CRISPR spacer
aagatattcattactacaaggaatttgtggatttgttttcgtca-	Protospacer
******************************* ***** .****

2. spacer 2.63|1141209|44|NZ_CP018187|CRISPRCasFinder matches to NZ_CP018188 (Streptococcus salivarius strain ICDC2 plasmid, complete sequence) position: , mismatch: 4, identity: 0.909

aagatattcattactacaaggaatttgtgga-ttgttaccgtccc	CRISPR spacer
aagatattcattactacaaggaatttgtggatttgttttcgtca-	Protospacer
******************************* ***** .****

3. spacer 2.63|1141209|44|NZ_CP018187|CRISPRCasFinder matches to NZ_CP020439 (Streptococcus equinus strain FDAARGOS_251 plasmid unamed1 sequence) position: , mismatch: 4, identity: 0.909

aagatattcattactacaaggaatttgtgga-ttgttaccgtccc	CRISPR spacer
aagatattcattactacaaggaatttgtggatttgttttcgtca-	Protospacer
******************************* ***** .****

4. spacer 2.63|1141209|44|NZ_CP018187|CRISPRCasFinder matches to NZ_CP040803 (Streptococcus salivarius strain LAB813 plasmid pSAL813, complete sequence) position: , mismatch: 5, identity: 0.886

aagatattcattactacaaggaatttgtgga-ttgttaccgtccc	CRISPR spacer
aagatattcattactataaggaatttgtggatttgttttcgtca-	Protospacer
****************.************** ***** .****

5. spacer 2.63|1141209|44|NZ_CP018187|CRISPRCasFinder matches to MN480763 (Streptococcus salivarius strain YU10 plasmid pSsal-YU10, complete sequence) position: , mismatch: 5, identity: 0.886

aagatattcattactacaaggaatttgtgga-ttgttaccgtccc	CRISPR spacer
aagatattcattactataaggaatttgtggatttgttttcgtca-	Protospacer
****************.************** ***** .****

6. spacer 2.63|1141209|44|NZ_CP018187|CRISPRCasFinder matches to MN480762 (Streptococcus salivarius strain NU10 plasmid pSsal-NU10, complete sequence) position: , mismatch: 5, identity: 0.886

aagatattcattactacaaggaatttgtgga-ttgttaccgtccc	CRISPR spacer
aagatattcattactataaggaatttgtggatttgttttcgtca-	Protospacer
****************.************** ***** .****

7. spacer 2.62|1141136|48|NZ_CP018187|CRISPRCasFinder matches to NZ_CP018188 (Streptococcus salivarius strain ICDC2 plasmid, complete sequence) position: , mismatch: 6, identity: 0.875

gcacctctacctgaagcggatgaaccgcaacctttgagt-ttccgtccc	CRISPR spacer
gcacctctacctgaagcggatgaaccgcaacctttgaatgagtcgtca-	Protospacer
*************************************.*   .****

8. spacer 2.62|1141136|48|NZ_CP018187|CRISPRCasFinder matches to MN480762 (Streptococcus salivarius strain NU10 plasmid pSsal-NU10, complete sequence) position: , mismatch: 7, identity: 0.854

gcacctctacctgaagcggatgaaccgcaacctttgagt-ttccgtccc	CRISPR spacer
gcacctctacctgaaacggatgaaccgcaacctttgaatgagtcgtca-	Protospacer
***************.*********************.*   .****

9. spacer 2.62|1141136|48|NZ_CP018187|CRISPRCasFinder matches to MN480763 (Streptococcus salivarius strain YU10 plasmid pSsal-YU10, complete sequence) position: , mismatch: 7, identity: 0.854

gcacctctacctgaagcggatgaaccgcaacctttgagt-ttccgtccc	CRISPR spacer
gcacctctacctgaaacggatgaaccgcaacctttgaatgagtcgtca-	Protospacer
***************.*********************.*   .****

10. spacer 2.27|1141121|52|NZ_CP018187|CRT matches to NZ_CP018188 (Streptococcus salivarius strain ICDC2 plasmid, complete sequence) position: , mismatch: 9, identity: 0.827

---acataggtttatagcgcacctctacctgaagcggatgaaccgcaacctttga	CRISPR spacer
gaaaaacagg---aggcagcacctctacctgaagcggatgaaccgcaacctttga	Protospacer
   * *.***   * .  *************************************

11. spacer 2.28|1141194|48|NZ_CP018187|CRT matches to NZ_CP020439 (Streptococcus equinus strain FDAARGOS_251 plasmid unamed1 sequence) position: , mismatch: 9, identity: 0.812

ggataggtttat----atcaagatattcattactacaaggaatttgtggatt	CRISPR spacer
----aatcctatacgaatgaagatattcattactacaaggaatttgtggatt	Protospacer
    *. ..***    ** *********************************

12. spacer 2.28|1141194|48|NZ_CP018187|CRT matches to NZ_CP020429 (Streptococcus sp. FDAARGOS_192 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.812

ggataggtttat----atcaagatattcattactacaaggaatttgtggatt	CRISPR spacer
----aatcctatacgaatgaagatattcattactacaaggaatttgtggatt	Protospacer
    *. ..***    ** *********************************

13. spacer 2.28|1141194|48|NZ_CP018187|CRT matches to NZ_CP018188 (Streptococcus salivarius strain ICDC2 plasmid, complete sequence) position: , mismatch: 9, identity: 0.812

ggataggtttat----atcaagatattcattactacaaggaatttgtggatt	CRISPR spacer
----aatcctatacgaatgaagatattcattactacaaggaatttgtggatt	Protospacer
    *. ..***    ** *********************************

14. spacer 2.28|1141194|48|NZ_CP018187|CRT matches to MN480762 (Streptococcus salivarius strain NU10 plasmid pSsal-NU10, complete sequence) position: , mismatch: 9, identity: 0.812

ggataggtttat----atcaagatattcattactacaaggaatttgtggatt	CRISPR spacer
----agtcctatacgaatgaagatattcattactataaggaatttgtggatt	Protospacer
    ** ..***    ** ****************.****************

15. spacer 2.47|1140039|48|NZ_CP018187|CRISPRCasFinder matches to NC_018285 (Streptococcus phage YMC-2011, complete genome) position: , mismatch: 9, identity: 0.812

aaaacgaaaacctcttgattgagttggaagaagcaaa-------gttaccgtccc	CRISPR spacer
aaaacgaaaacctcttgattgagttggaagaagcaaataaaaacgctg-------	Protospacer
*************************************       *.*.

16. spacer 2.12|1140024|52|NZ_CP018187|CRT matches to NC_018285 (Streptococcus phage YMC-2011, complete genome) position: , mismatch: 10, identity: 0.808

---atatgggtttatatcaaaacgaaaacctcttgattgagttggaagaagcaaa	CRISPR spacer
aactcttgga---aagccaaaacgaaaacctcttgattgagttggaagaagcaaa	Protospacer
    . ***.   * ..**************************************

17. spacer 2.27|1141121|52|NZ_CP018187|CRT matches to MN480762 (Streptococcus salivarius strain NU10 plasmid pSsal-NU10, complete sequence) position: , mismatch: 10, identity: 0.808

---acataggtttatagcgcacctctacctgaagcggatgaaccgcaacctttga	CRISPR spacer
gaaaaacagg---aggcagcacctctacctgaaacggatgaaccgcaacctttga	Protospacer
   * *.***   * .  ***************.*********************

18. spacer 2.27|1141121|52|NZ_CP018187|CRT matches to MN480763 (Streptococcus salivarius strain YU10 plasmid pSsal-YU10, complete sequence) position: , mismatch: 10, identity: 0.808

---acataggtttatagcgcacctctacctgaagcggatgaaccgcaacctttga	CRISPR spacer
gaaaaacagg---aggcagcacctctacctgaaacggatgaaccgcaacctttga	Protospacer
   * *.***   * .  ***************.*********************

19. spacer 2.45|1139896|47|NZ_CP018187|CRISPRCasFinder matches to MH892354 (Streptococcus phage SW3, complete genome) position: , mismatch: 10, identity: 0.787

cgaatggattgaaaaaaacttggagaatatccgata-------gtttccgtccc	CRISPR spacer
agaatggattgaaaaaaacttggagaatatccgataaaaaaacatat-------	Protospacer
 ***********************************       .* *

20. spacer 2.47|1140039|48|NZ_CP018187|CRISPRCasFinder matches to MF417874 (Uncultured Caudovirales phage clone 3S_14, partial genome) position: , mismatch: 10, identity: 0.792

aaaacgaaaacctcttgattgagttggaagaagc----aaagttaccgtccc	CRISPR spacer
aaaatgaaaacctcttgattgagttggaagaagcgactaaaaacgctg----	Protospacer
****.*****************************    ***. ..*.*

21. spacer 2.53|1140474|48|NZ_CP018187|CRISPRCasFinder matches to FJ965538 (Streptococcus phage 5093, complete genome) position: , mismatch: 10, identity: 0.792

acttcaagaattgcaagaatacgcttttaacgtttt-----ggtttccgtccc	CRISPR spacer
atttcaagaattacaagaatacgcttttaacgttttaagagaatatcc-----	Protospacer
*.**********.***********************     ..* ***

22. spacer 2.54|1140547|50|NZ_CP018187|CRISPRCasFinder matches to NZ_CP020439 (Streptococcus equinus strain FDAARGOS_251 plasmid unamed1 sequence) position: , mismatch: 10, identity: 0.8

agttcgtaaaatatgatgatacatacaaagaagaagccagttaccgtccc	CRISPR spacer
agttcgtaaaatatgatgataaatacaaagaagaagccattttagacttt	Protospacer
********************* ***************** **   .....

23. spacer 2.54|1140547|50|NZ_CP018187|CRISPRCasFinder matches to NZ_CP020430 (Streptococcus sp. FDAARGOS_192 plasmid unnamed2 sequence) position: , mismatch: 10, identity: 0.8

agttcgtaaaatatgatgatacatacaaagaagaagccagttaccgtccc	CRISPR spacer
agttcgtaaaatatgatgataaatacaaagaagaagccattttagacttt	Protospacer
********************* ***************** **   .....

24. spacer 2.54|1140547|50|NZ_CP018187|CRISPRCasFinder matches to NZ_CP020430 (Streptococcus sp. FDAARGOS_192 plasmid unnamed2 sequence) position: , mismatch: 10, identity: 0.8

agttcgtaaaatatgatgatacatacaaagaagaagccagttaccgtccc	CRISPR spacer
agttcgtaaaatatgatgataaatacaaagaagaagccattttagacttt	Protospacer
********************* ***************** **   .....

25. spacer 2.54|1140547|50|NZ_CP018187|CRISPRCasFinder matches to NZ_CP020429 (Streptococcus sp. FDAARGOS_192 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.8

agttcgtaaaatatgatgatacatacaaagaagaagccagttaccgtccc	CRISPR spacer
agttcgtaaaatatgatgataaatacaaagaagaagccattttagacttt	Protospacer
********************* ***************** **   .....

26. spacer 2.54|1140547|50|NZ_CP018187|CRISPRCasFinder matches to MN480763 (Streptococcus salivarius strain YU10 plasmid pSsal-YU10, complete sequence) position: , mismatch: 10, identity: 0.8

agttcgtaaaatatgatgatacatacaaagaagaagccagttaccgtccc	CRISPR spacer
agttcgtaaaatatgatgataaatacaaagaagaagccattttagacttt	Protospacer
********************* ***************** **   .....

27. spacer 2.58|1140843|48|NZ_CP018187|CRISPRCasFinder matches to NC_018285 (Streptococcus phage YMC-2011, complete genome) position: , mismatch: 10, identity: 0.792

taatggacgcacaaacaaaagcaaccaagaaatggaagttaccgtccc	CRISPR spacer
caatggacgcacaaacaaaagcaactaaaaaatggaactcgcagaaca	Protospacer
.************************.**.******** *..* *  *

28. spacer 2.59|1140916|49|NZ_CP018187|CRISPRCasFinder matches to MF417874 (Uncultured Caudovirales phage clone 3S_14, partial genome) position: , mismatch: 10, identity: 0.796

agcaggactagacaaggatacattcaaggacaagtacggtttccgtccc	CRISPR spacer
agcgggactagacaaggacacattcaaggacaagtacgagagcttttct	Protospacer
***.**************.*******************.   *. *.*.

29. spacer 2.5|1139526|51|NZ_CP018187|CRT matches to CP029253 (Streptococcus phage VS-2018a, complete genome) position: , mismatch: 11, identity: 0.784

aggtaggtttatatcccttgaaactattatgactattcaaaagtggattga	CRISPR spacer
gcttgagaacctaacccttgaaactattatgactattcaaaagtggataga	Protospacer
.  *..*  . ** ********************************** **

30. spacer 2.5|1139526|51|NZ_CP018187|CRT matches to NC_022776 (Streptococcus phage TP-778L complete genome) position: , mismatch: 11, identity: 0.784

aggtaggtttatatcccttgaaactattatgactattcaaaagtggattga	CRISPR spacer
gcttgagaacctaacccttgaaactattatgactattcaaaagtggataga	Protospacer
.  *..*  . ** ********************************** **

31. spacer 2.28|1141194|48|NZ_CP018187|CRT matches to NZ_CP040803 (Streptococcus salivarius strain LAB813 plasmid pSAL813, complete sequence) position: , mismatch: 11, identity: 0.771

ggataggtttatatcaagatattcattactacaaggaatttgtggatt	CRISPR spacer
agtcctatacaaatgaagatattcattactataaggaatttgtggatt	Protospacer
.* .  .* .* ** ****************.****************

32. spacer 2.28|1141194|48|NZ_CP018187|CRT matches to MN480763 (Streptococcus salivarius strain YU10 plasmid pSsal-YU10, complete sequence) position: , mismatch: 11, identity: 0.771

ggataggtttatatcaagatattcattactacaaggaatttgtggatt	CRISPR spacer
agtcctatacaaatgaagatattcattactataaggaatttgtggatt	Protospacer
.* .  .* .* ** ****************.****************

33. spacer 2.40|1139541|47|NZ_CP018187|CRISPRCasFinder matches to CP029253 (Streptococcus phage VS-2018a, complete genome) position: , mismatch: 11, identity: 0.766

ccttgaaactattatgactattcaaaagtggattg--------agtttccgtccc	CRISPR spacer
ccttgaaactattatgactattcaaaagtggatagatgaaggaaact--------	Protospacer
********************************* *        *..*

34. spacer 2.40|1139541|47|NZ_CP018187|CRISPRCasFinder matches to NC_022776 (Streptococcus phage TP-778L complete genome) position: , mismatch: 11, identity: 0.766

ccttgaaactattatgactattcaaaagtggattg--------agtttccgtccc	CRISPR spacer
ccttgaaactattatgactattcaaaagtggatagatgaaggaaact--------	Protospacer
********************************* *        *..*

35. spacer 2.53|1140474|48|NZ_CP018187|CRISPRCasFinder matches to KY705259 (Streptococcus phage P5641, complete genome) position: , mismatch: 11, identity: 0.771

acttcaagaattgcaagaatacgcttttaacgttttggtttccgtccc	CRISPR spacer
atttcaagaattacaagaatacgcttttaacgttttaagagaataccc	Protospacer
*.**********.***********************..       ***

36. spacer 2.53|1140474|48|NZ_CP018187|CRISPRCasFinder matches to MH937461 (Streptococcus phage CHPC642, complete genome) position: , mismatch: 11, identity: 0.771

acttcaagaattgcaagaatacgcttttaacgttttggtttccgtccc	CRISPR spacer
atttcaagaattacaagaatacgcttttaacgttttaagagaataccc	Protospacer
*.**********.***********************..       ***

37. spacer 2.53|1140474|48|NZ_CP018187|CRISPRCasFinder matches to MG708274 (Streptococcus phage vB_SthS_VA214, complete genome) position: , mismatch: 11, identity: 0.771

acttcaagaattgcaagaatacgcttttaacgttttggtttccgtccc	CRISPR spacer
atttcaagaattacaagaatacgcttttaacgttttaagagaataccc	Protospacer
*.**********.***********************..       ***

38. spacer 2.53|1140474|48|NZ_CP018187|CRISPRCasFinder matches to HG424323 (Streptococcus phage 20617 complete prophage genome) position: , mismatch: 11, identity: 0.771

acttcaagaattgcaagaatacgcttttaacgttttggtttccgtccc	CRISPR spacer
atttcaagaattacaagaatacgcttttaacgttttaagagaataccc	Protospacer
*.**********.***********************..       ***

39. spacer 2.53|1140474|48|NZ_CP018187|CRISPRCasFinder matches to AF020798 (Streptococcus thermophilus bacteriophage lysogeny module, integrase homolog (int), putative host cell surface-exposed lipoprotein, putative metallo-proteinase, repressor, Cro-like regulatory protein, and P1-antirepressor homolog genes, complete cds) position: , mismatch: 11, identity: 0.771

acttcaagaattgcaagaatacgcttttaacgtttt-----ggtttccgtccc	CRISPR spacer
atttcaagaattacaagaatacgcttttaacattttaagagaatatcc-----	Protospacer
*.**********.******************.****     ..* ***

40. spacer 2.53|1140474|48|NZ_CP018187|CRISPRCasFinder matches to NC_000871 (Streptococcus phage Sfi19, complete genome) position: , mismatch: 11, identity: 0.771

acttcaagaattgcaagaatacgcttttaacgtttt-----ggtttccgtccc	CRISPR spacer
atttcaagaattacaagaatacgcttttaacattttaagagaatatcc-----	Protospacer
*.**********.******************.****     ..* ***

41. spacer 2.53|1140474|48|NZ_CP018187|CRISPRCasFinder matches to AF158601 (Streptococcus thermophilus bacteriophage SFi18 lysin, gp111, gp183, gp47, gp54, gp71, gp145, gp69, gp40, gp229, gp157, gp233, putative helicase, gp151, gp271, putative primase, gp143, gp106, gp89, gp57, gp51, gp66, gp192, putative DNA binding protein, gp99, and gp235 genes, complete cds) position: , mismatch: 11, identity: 0.771

acttcaagaattgcaagaatacgcttttaacgtttt-----ggtttccgtccc	CRISPR spacer
atttcaagaattacaagaatacgcttttaacattttaagagaatatcc-----	Protospacer
*.**********.******************.****     ..* ***

42. spacer 2.53|1140474|48|NZ_CP018187|CRISPRCasFinder matches to HE861935 (Streptococcus phage TP-J34 complete genome) position: , mismatch: 11, identity: 0.771

acttcaagaattgcaagaatacgcttttaacgtttt-----ggtttccgtccc	CRISPR spacer
atttcaagaattacaagaatacgcttttaacattttaagagaatatcc-----	Protospacer
*.**********.******************.****     ..* ***

43. spacer 2.53|1140474|48|NZ_CP018187|CRISPRCasFinder matches to AF115102 (Streptococcus thermophilus bacteriophage Sfi19, complete genome) position: , mismatch: 11, identity: 0.771

acttcaagaattgcaagaatacgcttttaacgtttt-----ggtttccgtccc	CRISPR spacer
atttcaagaattacaagaatacgcttttaacattttaagagaatatcc-----	Protospacer
*.**********.******************.****     ..* ***

44. spacer 2.53|1140474|48|NZ_CP018187|CRISPRCasFinder matches to NC_002214 (Streptococcus thermophilus bacteriophage Sfi11, complete genome) position: , mismatch: 11, identity: 0.771

acttcaagaattgcaagaatacgcttttaacgtttt-----ggtttccgtccc	CRISPR spacer
atttcaagaattacaagaatacgcttttaacattttaagagaatatcc-----	Protospacer
*.**********.******************.****     ..* ***

45. spacer 2.53|1140474|48|NZ_CP018187|CRISPRCasFinder matches to MH937469 (Streptococcus phage CHPC919, complete genome) position: , mismatch: 11, identity: 0.771

acttcaagaattgcaagaatacgcttttaacgtttt-----ggtttccgtccc	CRISPR spacer
atttcaagaattacaagaatacgcttttaacattttaagagaatatcc-----	Protospacer
*.**********.******************.****     ..* ***

46. spacer 2.72|1141714|32|NZ_CP018187|PILER-CR matches to NZ_CP032924 (Agrobacterium tumefaciens strain 1D1108 plasmid pAt1D1108b, complete sequence) position: , mismatch: 11, identity: 0.656

tttctgattggacttttgaattcattacattt	CRISPR spacer
cggctgatcggacttttgaattcgttgttgga	Protospacer
.  *****.**************.**..

47. spacer 2.19|1140532|54|NZ_CP018187|CRT matches to NZ_CP020439 (Streptococcus equinus strain FDAARGOS_251 plasmid unamed1 sequence) position: , mismatch: 12, identity: 0.778

agatagggttatatcagttcgtaaaatatgatgatacatacaaagaagaagcca	CRISPR spacer
aagacgaacaaggacagttcgtaaaatatgatgataaatacaaagaagaagcca	Protospacer
*..  *... * . ********************** *****************

48. spacer 2.19|1140532|54|NZ_CP018187|CRT matches to NZ_CP020430 (Streptococcus sp. FDAARGOS_192 plasmid unnamed2 sequence) position: , mismatch: 12, identity: 0.778

agatagggttatatcagttcgtaaaatatgatgatacatacaaagaagaagcca	CRISPR spacer
aagacgaacaaggacagttcgtaaaatatgatgataaatacaaagaagaagcca	Protospacer
*..  *... * . ********************** *****************

49. spacer 2.19|1140532|54|NZ_CP018187|CRT matches to NZ_CP020430 (Streptococcus sp. FDAARGOS_192 plasmid unnamed2 sequence) position: , mismatch: 12, identity: 0.778

agatagggttatatcagttcgtaaaatatgatgatacatacaaagaagaagcca	CRISPR spacer
aagacgaacaaggacagttcgtaaaatatgatgataaatacaaagaagaagcca	Protospacer
*..  *... * . ********************** *****************

50. spacer 2.19|1140532|54|NZ_CP018187|CRT matches to NZ_CP020429 (Streptococcus sp. FDAARGOS_192 plasmid unnamed1, complete sequence) position: , mismatch: 12, identity: 0.778

agatagggttatatcagttcgtaaaatatgatgatacatacaaagaagaagcca	CRISPR spacer
aagacgaacaaggacagttcgtaaaatatgatgataaatacaaagaagaagcca	Protospacer
*..  *... * . ********************** *****************

51. spacer 2.19|1140532|54|NZ_CP018187|CRT matches to MN480763 (Streptococcus salivarius strain YU10 plasmid pSsal-YU10, complete sequence) position: , mismatch: 12, identity: 0.778

agatagggttatatcagttcgtaaaatatgatgatacatacaaagaagaagcca	CRISPR spacer
aagacgaacaaggacagttcgtaaaatatgatgataaatacaaagaagaagcca	Protospacer
*..  *... * . ********************** *****************

52. spacer 2.45|1139896|47|NZ_CP018187|CRISPRCasFinder matches to MF417874 (Uncultured Caudovirales phage clone 3S_14, partial genome) position: , mismatch: 12, identity: 0.745

cgaatggattgaaaaaaacttggagaatatccgata----------gtttccgtccc	CRISPR spacer
tgaatggattgaaaacaacttggagaatatccgataaaagactaggg----------	Protospacer
.************** ********************          *

53. spacer 2.53|1140474|48|NZ_CP018187|CRISPRCasFinder matches to KY705273 (Streptococcus phage P7602, complete genome) position: , mismatch: 12, identity: 0.75

acttcaagaattgcaagaatacgcttttaacgttttggtttccgtccc	CRISPR spacer
atttcaataattacaagaatacgcttttaacgttttaagagaataccc	Protospacer
*.***** ****.***********************..       ***

54. spacer 2.53|1140474|48|NZ_CP018187|CRISPRCasFinder matches to MH937479 (Streptococcus phage CHPC952, complete genome) position: , mismatch: 12, identity: 0.75

acttcaagaattgcaagaatacgcttttaacgttttggtttccgtccc	CRISPR spacer
atttcaataattacaagaatacgcttttaacgttttaagagaataccc	Protospacer
*.***** ****.***********************..       ***

55. spacer 2.53|1140474|48|NZ_CP018187|CRISPRCasFinder matches to MK202161 (Streptococcus phage CHPC1282, complete genome) position: , mismatch: 12, identity: 0.75

acttcaagaattgcaagaatacgcttttaacgttttggtttccgtccc	CRISPR spacer
atttcaataattacaagaatacgcttttaacgttttaagagaataccc	Protospacer
*.***** ****.***********************..       ***

56. spacer 2.53|1140474|48|NZ_CP018187|CRISPRCasFinder matches to MH937464 (Streptococcus phage CHPC869, complete genome) position: , mismatch: 12, identity: 0.75

acttcaagaattgcaagaatacgcttttaacgttttggtttccgtccc	CRISPR spacer
atttcaataattacaagaatacgcttttaacgttttaagagaataccc	Protospacer
*.***** ****.***********************..       ***

57. spacer 2.53|1140474|48|NZ_CP018187|CRISPRCasFinder matches to MH937480 (Streptococcus phage CHPC954, complete genome) position: , mismatch: 12, identity: 0.75

acttcaagaattgcaagaatacgcttttaacgttttggtttccgtccc	CRISPR spacer
atttcaataattacaagaatacgcttttaacgttttaagagaataccc	Protospacer
*.***** ****.***********************..       ***

58. spacer 2.53|1140474|48|NZ_CP018187|CRISPRCasFinder matches to MH937475 (Streptococcus phage CHPC931, complete genome) position: , mismatch: 12, identity: 0.75

acttcaagaattgcaagaatacgcttttaacgttttggtttccgtccc	CRISPR spacer
atttcaataattacaagaatacgcttttaacgttttaagagaataccc	Protospacer
*.***** ****.***********************..       ***

59. spacer 2.53|1140474|48|NZ_CP018187|CRISPRCasFinder matches to MH937503 (Streptococcus phage CHPC1084, complete genome) position: , mismatch: 12, identity: 0.75

acttcaagaattgcaagaatacgcttttaacgttttggtttccgtccc	CRISPR spacer
atttcaataattacaagaatacgcttttaacgttttaagagaataccc	Protospacer
*.***** ****.***********************..       ***

60. spacer 2.53|1140474|48|NZ_CP018187|CRISPRCasFinder matches to MH937505 (Streptococcus phage CHPC1109, complete genome) position: , mismatch: 12, identity: 0.75

acttcaagaattgcaagaatacgcttttaacgttttggtttccgtccc	CRISPR spacer
atttcaataattacaagaatacgcttttaacgttttaagagaataccc	Protospacer
*.***** ****.***********************..       ***

61. spacer 2.54|1140547|50|NZ_CP018187|CRISPRCasFinder matches to MN480762 (Streptococcus salivarius strain NU10 plasmid pSsal-NU10, complete sequence) position: , mismatch: 12, identity: 0.76

agttcgtaaaatatgatgatacatacaaagaagaagccagttaccgtccc	CRISPR spacer
agttcgtaaaatatgatgataaatacaaagaagaagctgttttagacttt	Protospacer
********************* ***************.. **   .....

62. spacer 2.19|1140532|54|NZ_CP018187|CRT matches to NZ_CP015284 (Streptococcus salivarius strain ATCC 25975 plasmid, complete sequence) position: , mismatch: 13, identity: 0.759

agatagggttatatcagttcgtaaaatatgatgatacatacaaagaagaagcca	CRISPR spacer
aagacgaacaaggacagttcgtaaaatacgatgataaatacaaagaagaagcca	Protospacer
*..  *... * . **************.******* *****************

63. spacer 2.19|1140532|54|NZ_CP018187|CRT matches to NZ_CP040803 (Streptococcus salivarius strain LAB813 plasmid pSAL813, complete sequence) position: , mismatch: 13, identity: 0.759

agatagggttatatcagttcgtaaaatatgatgatacatacaaagaagaagcca	CRISPR spacer
aagacgaacaaggacagttcgtaaaatatgatgataaatacaaagaagaggcca	Protospacer
*..  *... * . ********************** ************.****

64. spacer 2.19|1140532|54|NZ_CP018187|CRT matches to NZ_CP040803 (Streptococcus salivarius strain LAB813 plasmid pSAL813, complete sequence) position: , mismatch: 13, identity: 0.759

agatagggttatatcagttcgtaaaatatgatgatacatacaaagaagaagcca	CRISPR spacer
aagacgaacaaggacagttcgtaaaatatgatgataaatacaaagaagaggcca	Protospacer
*..  *... * . ********************** ************.****

65. spacer 2.19|1140532|54|NZ_CP018187|CRT matches to NZ_CP018188 (Streptococcus salivarius strain ICDC2 plasmid, complete sequence) position: , mismatch: 13, identity: 0.759

agatagggttatatcagttcgtaaaatatgatgatacatacaaagaagaagcca	CRISPR spacer
aagacgaacaaggacagttcgtaaaatatgatgataaatacaaagaagaggcca	Protospacer
*..  *... * . ********************** ************.****

66. spacer 2.24|1140901|53|NZ_CP018187|CRT matches to MF417874 (Uncultured Caudovirales phage clone 3S_14, partial genome) position: , mismatch: 13, identity: 0.755

gaataggtttgtatcagcaggactagacaaggatacattcaaggacaagtacg	CRISPR spacer
aagcaaatgcgagctagcgggactagacaaggacacattcaaggacaagtacg	Protospacer
.*..*..* .* ...***.**************.*******************

67. spacer 2.19|1140532|54|NZ_CP018187|CRT matches to MN480762 (Streptococcus salivarius strain NU10 plasmid pSsal-NU10, complete sequence) position: , mismatch: 14, identity: 0.741

agatagggttatatcagttcgtaaaatatgatgatacatacaaagaagaagcca	CRISPR spacer
aagacgaacaaggacagttcgtaaaatatgatgataaatacaaagaagaagctg	Protospacer
*..  *... * . ********************** ***************..

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

353675 : 359120

Streptococcus_phage(66.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002883723.1\|353675_354440_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	5.2e-15	24.8
WP_002883761.1\|354439_355150_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	6.3e-15	26.9
WP_037600377.1\|355284_355944_+	CBS domain-containing protein	M1NSC5	Streptococcus_phage	8.6e-67	59.6
WP_002883742.1\|356091_357018_-	cysteine synthase A	A0A1X9I5K7	Streptococcus_phage	9.4e-144	81.8
WP_060973192.1\|357119_357746_-	YigZ family protein	A0A1X9I5T8	Streptococcus_phage	8.7e-69	61.4
WP_156246369.1\|357800_359120_+	DEAD/DEAH box helicase	A0A1X9I5S6	Streptococcus_phage	2.2e-122	52.1

DBSCAN-SWA_2

588805 : 638204

Bacillus_virus(25.0%)

tRNA,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002890325.1\|588805_590752_+\|tRNA	threonine--tRNA ligase	A0A2K9L6B6	Tupanvirus	6.0e-116	36.8
WP_107372736.1\|590801_591740_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_107372737.1\|591769_592828_+	DUF3114 domain-containing protein	NA	NA	NA	NA
WP_060972440.1\|592903_594070_-	dipeptidyl aminopeptidase	NA	NA	NA	NA
WP_060972439.1\|594145_594463_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_002886147.1\|594634_594826_-	PspC domain-containing protein	NA	NA	NA	NA
WP_060972438.1\|594880_595558_-	hemolysin III family protein	NA	NA	NA	NA
WP_060972437.1\|595550_596000_-	DUF1836 domain-containing protein	NA	NA	NA	NA
WP_013990948.1\|596169_597441_-	hydroxymethylglutaryl-CoA reductase, degradative	NA	NA	NA	NA
WP_038675548.1\|597442_598609_-	hydroxymethylglutaryl-CoA synthase	NA	NA	NA	NA
WP_060971323.1\|599071_599932_+	thymidylate synthase	U5J9N5	Bacillus_phage	9.1e-85	53.7
WP_073950795.1\|600040_600544_+	dihydrofolate reductase	A0A1B2IAU3	Erwinia_phage	1.3e-17	33.3
WP_002886174.1\|600548_600719_+	hypothetical protein	NA	NA	NA	NA
WP_002890340.1\|600736_601963_+\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	9.2e-139	60.9
WP_002885996.1\|601972_602572_+	YihA family ribosome biogenesis GTP-binding protein	NA	NA	NA	NA
WP_156246543.1\|602700_604077_+	amino acid permease	NA	NA	NA	NA
WP_156246545.1\|604088_605039_+	homocysteine S-methyltransferase	NA	NA	NA	NA
WP_002886199.1\|605151_605406_+	DUF1912 family protein	NA	NA	NA	NA
WP_156246546.1\|605480_605858_+	helix-hairpin-helix domain-containing protein	NA	NA	NA	NA
WP_156246547.1\|605972_606614_-	glycerol-3-phosphate 1-O-acyltransferase PlsY	NA	NA	NA	NA
WP_156246548.1\|606751_608701_+	DNA topoisomerase IV subunit B	G3M9Z3	Bacillus_virus	1.7e-123	42.4
WP_156246549.1\|608856_609405_+	hypothetical protein	NA	NA	NA	NA
WP_156246550.1\|609409_609937_+	hypothetical protein	NA	NA	NA	NA
WP_118189023.1\|611122_611704_+	hypothetical protein	NA	NA	NA	NA
WP_037597558.1\|611696_612542_+	hypothetical protein	NA	NA	NA	NA
WP_080583689.1\|612707_613064_+	cell division protein	NA	NA	NA	NA
WP_002890361.1\|613733_614270_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_037598079.1\|614286_615120_+	aminoglycoside 6-adenylyltransferase	A0A1X9I6F2	Streptococcus_phage	3.9e-40	34.7
WP_037597568.1\|615100_615835_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_060972429.1\|615887_618344_+	DNA topoisomerase IV subunit A	G3M9Z5	Bacillus_virus	2.8e-94	32.6
WP_156246551.1\|618509_619532_+	branched-chain amino acid aminotransferase	NA	NA	NA	NA
WP_156246552.1\|619617_620643_-\|transposase	IS30 family transposase	Q9MBM9	Staphylococcus_prophage	9.1e-31	31.6
WP_156246553.1\|621046_621622_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_156246554.1\|621634_622060_+	hypothetical protein	NA	NA	NA	NA
WP_156247077.1\|622052_622934_+	ATP-binding cassette domain-containing protein	A0A2H4PQG7	Staphylococcus_phage	2.4e-24	34.8
WP_156246555.1\|622936_623695_+	hypothetical protein	NA	NA	NA	NA
WP_156246556.1\|623712_625449_+	ATP-binding cassette domain-containing protein	W8CYL7	Bacillus_phage	2.4e-52	29.3
WP_156246557.1\|626229_626391_+	hypothetical protein	NA	NA	NA	NA
WP_129852440.1\|626482_627685_-\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	1.0e-195	85.8
WP_003094841.1\|630559_631762_+	30S ribosomal protein S1	NA	NA	NA	NA
WP_048675996.1\|632546_633167_+	DUF3862 domain-containing protein	NA	NA	NA	NA
WP_156246558.1\|633249_633933_+	hypothetical protein	NA	NA	NA	NA
WP_156246559.1\|634012_634975_+	gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_002885967.1\|635020_635323_-	DUF1827 family protein	NA	NA	NA	NA
WP_151404407.1\|635332_635791_-	NUDIX hydrolase	NA	NA	NA	NA
WP_073687523.1\|635933_638204_-\|protease	ATP-dependent Clp protease ATP-binding subunit	K4FB40	Cronobacter_phage	2.1e-128	40.9

DBSCAN-SWA_3

664807 : 675698

Streptococcus_phage(87.5%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_156246574.1\|664807_665923_+	glycerate kinase	W6LM47	Streptococcus_phage	9.2e-138	86.3
WP_048790536.1\|665953_666409_-	YueI family protein	W6LLD2	Streptococcus_phage	1.1e-65	82.8
WP_002886048.1\|666614_667919_+	phosphopyruvate hydratase	W6LP63	Streptococcus_phage	1.4e-246	99.5
WP_002890454.1\|668068_668254_-	hypothetical protein	W6LMT3	Streptococcus_phage	7.3e-24	90.2
WP_156246575.1\|668424_670605_-	sulfatase-like hydrolase/transferase	W6LM83	Streptococcus_phage	0.0e+00	95.0
WP_037603989.1\|670766_671930_+	class I SAM-dependent rRNA methyltransferase	W6LLI2	Streptococcus_phage	5.0e-211	94.8
WP_037603987.1\|671926_672604_+	type I 3-dehydroquinate dehydratase	W6LP76	Streptococcus_phage	3.9e-115	93.8
WP_084869397.1\|672593_673451_+	shikimate dehydrogenase	NA	NA	NA	NA
WP_084869395.1\|673463_674531_+	3-dehydroquinate synthase	NA	NA	NA	NA
WP_070439237.1\|674531_675698_+	chorismate synthase	A0A291AU41	Pandoravirus	3.5e-39	34.7

DBSCAN-SWA_4

685145 : 740497

Streptococcus_phage(27.78%)

transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_084869183.1\|685145_686507_+	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	F5CA72	Streptococcus_phi-m46.1-like_phage	3.2e-201	78.2
WP_084870157.1\|686978_687188_+	helix-turn-helix domain-containing protein	A0A1B1IUF9	uncultured_Mediterranean_phage	1.3e-13	52.5
WP_156246578.1\|687189_687447_+	hypothetical protein	NA	NA	NA	NA
WP_156246579.1\|687454_688771_-\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	4.1e-44	32.5
WP_142255260.1\|688819_688969_+	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_061424511.1\|689099_689315_+	hypothetical protein	A0A2K5B2B1	Erysipelothrix_phage	5.3e-10	56.6
WP_061424514.1\|689377_690937_+	recombinase family protein	A0A2K5B2B2	Erysipelothrix_phage	3.7e-153	53.3
WP_084870164.1\|690937_691351_+	recombinase	NA	NA	NA	NA
WP_084870166.1\|691354_692926_+	recombinase family protein	A0A2K5B2B4	Erysipelothrix_phage	3.5e-175	61.8
WP_000417519.1\|693356_694574_+	macrolide efflux MFS transporter Mef(A)	A0A2K5B2B5	Erysipelothrix_phage	5.1e-198	90.6
WP_156246580.1\|694693_696157_+	Msr family ABC-F type ribosomal protection protein	A0A1B0RXA0	Streptococcus_phage	1.2e-246	91.8
WP_051651765.1\|696303_696813_+	DinB family protein	NA	NA	NA	NA
WP_061424519.1\|696861_697443_+	nitroreductase family protein	NA	NA	NA	NA
WP_061424521.1\|698251_698911_+	type A chloramphenicol O-acetyltransferase	A0A1X9I6V6	Streptococcus_phage	1.2e-57	47.2
WP_002890479.1\|699572_699704_+	hypothetical protein	NA	NA	NA	NA
WP_084869760.1\|700016_700637_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_002890483.1\|702202_702820_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_156246581.1\|702928_703639_+	ATP-binding cassette domain-containing protein	A0A1V0SE00	Indivirus	3.1e-14	28.5
WP_156246582.1\|703631_705191_+	hypothetical protein	NA	NA	NA	NA
WP_002890487.1\|705209_705431_+	DUF1648 domain-containing protein	NA	NA	NA	NA
WP_002890488.1\|705427_705769_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_002890489.1\|705937_706690_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_002890490.1\|706883_707447_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_002890492.1\|707647_708214_+	hypothetical protein	NA	NA	NA	NA
WP_002890497.1\|708393_708576_+	hypothetical protein	NA	NA	NA	NA
WP_002890498.1\|709028_709658_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_002890499.1\|709935_710676_+	ABC transporter permease subunit	NA	NA	NA	NA
WP_002890501.1\|710810_711548_+	ATP-binding cassette domain-containing protein	A0A2H4PQG7	Staphylococcus_phage	3.8e-39	44.1
WP_002890503.1\|711550_713233_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	5.8e-35	25.8
WP_037600270.1\|713737_714514_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_156246583.1\|714546_715284_+	DUF4336 domain-containing protein	NA	NA	NA	NA
WP_002883780.1\|715574_716039_+\|transposase	IS200/IS605 family transposase	A0A0H3UZM0	Geobacillus_virus	1.7e-16	35.0
WP_061652239.1\|716192_717365_-	MFS transporter	NA	NA	NA	NA
WP_155198122.1\|717585_718428_-	DegV family EDD domain-containing protein	A0A1X9I5J4	Streptococcus_phage	1.3e-107	69.9
WP_156246584.1\|718553_719123_+	TetR family transcriptional regulator	A0A1X9I6A2	Streptococcus_phage	2.7e-16	47.8
WP_156246585.1\|719222_719795_+	HD domain-containing protein	A0A1M7XV04	Cedratvirus	1.7e-10	32.5
WP_156246586.1\|719844_720669_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_156246587.1\|720710_721346_+	copper homeostasis protein CutC	NA	NA	NA	NA
WP_003094891.1\|721469_721742_+	hypothetical protein	NA	NA	NA	NA
WP_156246588.1\|721860_723108_+	DUF4767 domain-containing protein	NA	NA	NA	NA
WP_156246589.1\|723238_724078_+	DUF4300 family protein	NA	NA	NA	NA
WP_156246590.1\|724126_724873_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_156246591.1\|725046_726090_+	iron chelate uptake ABC transporter family permease subunit	NA	NA	NA	NA
WP_064523342.1\|726094_726850_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.7e-16	31.7
WP_156246592.1\|726870_727887_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_156247078.1\|727873_728557_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_156246593.1\|728849_729731_-	YegS/Rv2252/BmrU family lipid kinase	NA	NA	NA	NA
WP_156246594.1\|729834_730860_-	DUF389 domain-containing protein	NA	NA	NA	NA
WP_002890536.1\|731624_731864_+	GlsB/YeaQ/YmgE family stress response membrane protein	NA	NA	NA	NA
WP_002886207.1\|732120_732324_+	CsbD family protein	NA	NA	NA	NA
WP_156246595.1\|732888_734229_+	dihydrolipoyl dehydrogenase	A0A2K5B2C5	Erysipelothrix_phage	5.7e-41	26.8
WP_014634179.1\|734332_735406_+	thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha	NA	NA	NA	NA
WP_156246596.1\|735422_736454_+	alpha-ketoacid dehydrogenase subunit beta	NA	NA	NA	NA
WP_156246597.1\|736464_737694_+	2-oxo acid dehydrogenase subunit E2	NA	NA	NA	NA
WP_156246598.1\|737893_738487_-	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_064523345.1\|739339_739651_+	hypothetical protein	NA	NA	NA	NA
WP_156246599.1\|739747_740497_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_5

1203616 : 1214269

Streptococcus_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060971372.1\|1203616_1205179_+	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	9.3e-19	29.8
WP_156246765.1\|1205456_1206041_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_156246766.1\|1206323_1207343_-	alcohol dehydrogenase AdhP	A0A2K9L339	Tupanvirus	2.3e-26	25.2
WP_037600001.1\|1207504_1207786_-	hypothetical protein	M1PG86	Streptococcus_phage	2.7e-22	58.4
WP_156246767.1\|1207763_1208141_-	hypothetical protein	M1PLN9	Streptococcus_phage	6.5e-19	44.8
WP_156246768.1\|1208137_1209553_-	DNA polymerase	M1Q231	Streptococcus_phage	1.5e-193	70.7
WP_060971242.1\|1209666_1210518_-	amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_014634575.1\|1210530_1211160_-	amino acid ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.9e-31	39.7
WP_156246769.1\|1211168_1211810_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_156246770.1\|1212010_1212343_-	alkylphosphonate utilization protein	NA	NA	NA	NA
WP_156246771.1\|1212460_1214269_-	glutamine--fructose-6-phosphate transaminase (isomerizing)	A7IW18	Paramecium_bursaria_Chlorella_virus	1.5e-100	39.4

DBSCAN-SWA_6

1740470 : 1750713

Streptococcus_phage(71.43%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_037601635.1\|1740470_1742423_-	DNA topoisomerase (ATP-hydrolyzing) subunit B	G3M9Z3	Bacillus_virus	2.6e-143	45.6
WP_155222460.1\|1742423_1742984_-	HAD-IA family hydrolase	NA	NA	NA	NA
WP_156246961.1\|1743069_1743765_-	LrgB family protein	NA	NA	NA	NA
WP_037598332.1\|1743757_1744132_-	murein hydrolase regulator LrgA	NA	NA	NA	NA
WP_037598335.1\|1744412_1744766_-	arsenate reductase family protein	M1PLC0	Streptococcus_phage	4.1e-39	65.8
WP_156246962.1\|1744800_1745295_-	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	1.4e-34	45.1
WP_156246963.1\|1745349_1746528_-	phosphoglycerate dehydrogenase	M1NSB9	Streptococcus_phage	3.9e-179	79.8
WP_156246964.1\|1746546_1747104_-	GNAT family N-acetyltransferase	M1PSC3	Streptococcus_phage	2.0e-56	59.6
WP_014634872.1\|1747116_1748211_-	3-phosphoserine/phosphohydroxythreonine transaminase	M1Q1P2	Streptococcus_phage	1.6e-171	81.3
WP_156246965.1\|1748365_1749259_-	ROK family protein	NA	NA	NA	NA
WP_156246966.1\|1749374_1749770_+	lactoylglutathione lyase	NA	NA	NA	NA
WP_002891518.1\|1749813_1750713_-	SPFH domain-containing protein	A0A1V0SL90	Klosneuvirus	1.8e-35	32.8

DBSCAN-SWA_7

2058154 : 2103426

Lactobacillus_phage(28.57%)

tRNA,bacteriocin,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_070576644.1\|2058154_2059297_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	3.2e-85	42.8
WP_002885866.1\|2059501_2059636_-	50S ribosomal protein L34	NA	NA	NA	NA
WP_156247037.1\|2059831_2060395_-	flavodoxin family protein	NA	NA	NA	NA
WP_156247038.1\|2060391_2060988_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_156247039.1\|2061116_2062160_-	KH domain-containing protein	NA	NA	NA	NA
WP_037601519.1\|2062171_2062978_-	membrane protein insertase YidC	NA	NA	NA	NA
WP_155213332.1\|2063092_2063428_-	ribonuclease P protein component	NA	NA	NA	NA
WP_037601513.1\|2063512_2064898_-	argininosuccinate lyase	NA	NA	NA	NA
WP_037598503.1\|2065224_2066424_-	argininosuccinate synthase	NA	NA	NA	NA
WP_156247040.1\|2067365_2068109_-	response regulator	NA	NA	NA	NA
WP_156247041.1\|2068110_2069427_-	GHKL domain-containing protein	NA	NA	NA	NA
WP_156247042.1\|2069447_2070728_-	hypothetical protein	NA	NA	NA	NA
WP_156247043.1\|2070749_2071640_-	histidine kinase	NA	NA	NA	NA
WP_037600068.1\|2071695_2073003_-	GHKL domain-containing protein	NA	NA	NA	NA
WP_060973050.1\|2073468_2074923_-\|tRNA	glutamate--tRNA ligase	NA	NA	NA	NA
WP_060973051.1\|2075158_2077129_-	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_037598508.1\|2077310_2078000_-	50S ribosomal protein L1	NA	NA	NA	NA
WP_002885648.1\|2078099_2078525_-	50S ribosomal protein L11	NA	NA	NA	NA
WP_060973052.1\|2078696_2079050_+	DUF3397 domain-containing protein	NA	NA	NA	NA
WP_002886981.1\|2079144_2079642_-	carbonic anhydrase	NA	NA	NA	NA
WP_037598509.1\|2079793_2080489_-	TIGR00266 family protein	NA	NA	NA	NA
WP_082759652.1\|2080577_2081939_-	DNA repair protein RadA	NA	NA	NA	NA
WP_060973054.1\|2081935_2082403_-	cysteine hydrolase	NA	NA	NA	NA
WP_002886985.1\|2082412_2082859_-	dUTP diphosphatase	Q332E8	Clostridium_botulinum_C_phage	5.5e-33	50.0
WP_002886986.1\|2083065_2083668_+	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	1.8e-55	54.2
WP_060973055.1\|2083686_2084937_+	NADPH-dependent FMN reductase	A0A2P0ZL82	Lactobacillus_phage	5.8e-56	53.2
WP_060973056.1\|2085053_2085845_+	formate/nitrite transporter family protein	NA	NA	NA	NA
WP_060973057.1\|2085853_2086414_+	MptD family putative ECF transporter S component	NA	NA	NA	NA
WP_037598511.1\|2086532_2087555_+	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_037601510.1\|2087572_2088487_+	UTP--glucose-1-phosphate uridylyltransferase GalU	A0A127AW70	Bacillus_phage	3.7e-76	51.5
WP_060973058.1\|2088532_2089207_-\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_060973059.1\|2089197_2089725_-	5-formyltetrahydrofolate cyclo-ligase	NA	NA	NA	NA
WP_060973060.1\|2089793_2090927_-	N-acetyldiaminopimelate deacetylase	NA	NA	NA	NA
WP_060973061.1\|2091005_2091704_-	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase	NA	NA	NA	NA
WP_037598514.1\|2091789_2092542_-	HAD family hydrolase	NA	NA	NA	NA
WP_156247044.1\|2092655_2093495_-	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_002885650.1\|2093915_2094074_+\|bacteriocin	class IIb bacteriocin, lactobin A/cerein 7B family	NA	NA	NA	NA
WP_002887002.1\|2094093_2094261_+\|bacteriocin	class IIb bacteriocin, lactobin A/cerein 7B family	NA	NA	NA	NA
WP_045001373.1\|2094308_2094563_+	hypothetical protein	NA	NA	NA	NA
WP_014632555.1\|2094648_2095167_-	nucleoside deaminase	NA	NA	NA	NA
WP_014632554.1\|2095949_2096342_-	single-stranded DNA-binding protein	A1EAD1	Streptococcus_phage	7.5e-26	47.0
WP_045001371.1\|2096769_2097447_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_002885779.1\|2097712_2098336_-\|tRNA	DUF4479 and tRNA-binding domain-containing protein	NA	NA	NA	NA
WP_156247045.1\|2098367_2098892_-	hypothetical protein	NA	NA	NA	NA
WP_002885723.1\|2098895_2099210_-	thioredoxin family protein	NA	NA	NA	NA
WP_002885838.1\|2099206_2099491_-	DUF4651 domain-containing protein	NA	NA	NA	NA
WP_014632550.1\|2099590_2100658_+	glutamyl aminopeptidase	NA	NA	NA	NA
WP_002885846.1\|2100673_2101444_+	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	5.6e-33	36.1
WP_111686674.1\|2101470_2102133_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_013991259.1\|2102245_2102692_-	hypothetical protein	NA	NA	NA	NA
WP_037601483.1\|2102769_2103426_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_8

2232187 : 2243621

Staphylococcus_phage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014632484.1\|2232187_2232886_-	transglycosylase SLT domain-containing protein	Q4Z8Z7	Staphylococcus_phage	2.1e-26	68.8
WP_014632483.1\|2233069_2233651_-	LysM peptidoglycan-binding domain-containing protein	A0A249XZV3	Enterococcus_phage	4.6e-24	54.1
WP_045001313.1\|2233951_2234746_-	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
WP_045772057.1\|2234738_2235581_-	energy-coupling factor transporter ATPase	A0A2H4PQG7	Staphylococcus_phage	1.8e-13	27.9
WP_002885731.1\|2235556_2236387_-	energy-coupling factor transporter ATPase	G9BWD6	Planktothrix_phage	1.8e-21	32.7
WP_002885640.1\|2236399_2236942_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
WP_013991336.1\|2236954_2237812_-	DUF4115 domain-containing protein	NA	NA	NA	NA
WP_014632479.1\|2237870_2239148_-	insulinase family protein	A0A2H4UVM3	Bodo_saltans_virus	1.3e-05	28.7
WP_013991338.1\|2239149_2240400_-	insulinase family protein	A0A1X9I714	Streptococcus_phage	2.5e-91	39.9
WP_049528182.1\|2240477_2240855_+	S4 domain-containing protein YaaA	A0A1X9I5V8	Streptococcus_phage	2.5e-23	71.1
WP_013991340.1\|2240857_2241958_+	DNA replication/repair protein RecF	NA	NA	NA	NA
WP_021144763.1\|2242139_2243621_-	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	5.8e-95	40.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP018188

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP018188_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018188_1

106824-106917

Orphan

Consensus_repeat	Method
GGTTTTGTTACTGTTCTATTTGACATGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018188_1

>merge|NZ_CP018188|1|106824-106917|CRISPRCasFinder
GGTTTTGTTACTGTTCTATTTGACATGGTACTAAAACTTAGAGGAAGGTTAACCTTTAAAGTACATGGTTTTGTTACTGTTCTATTTGATATGG

>NZ_CP018188|1|1|106824-106917|CRISPRCasFinder
GGTTTTGTTACTGTTCTATTTGACATGG	TACTAAAACTTAGAGGAAGGTTAACCTTTAAAGTACAT
GGTTTTGTTACTGTTCTATTTGATATGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018188.1\|WP_156247166.1\|112883_113372_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018188.1\|WP_156247164.1\|111694_112003_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018188.1\|WP_156247159.1\|107569_107890_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018188.1\|WP_156247158.1\|105369_106662_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018188.1\|WP_156247155.1\|102415_102961_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018188.1\|WP_156247167.1\|113424_113868_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP018188.1\|WP_156247151.1\|98670_99033_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018188.1\|WP_156247162.1\|108787_109636_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378917
NZ_CP018188.1\|WP_156247165.1\|112211_112868_+\|DNA-repair-protein-RadC	unknown	unknown	gnl\|CDD\|178801
NZ_CP018188.1\|WP_156247161.1\|108285_108714_+\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|180915
NZ_CP018188.1\|WP_156247157.1\|104316_105045_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018188.1\|WP_156247160.1\|107902_108271_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018188.1\|WP_156247220.1\|97744_98653_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379384
NZ_CP018188.1\|WP_156247152.1\|99173_99971_+\|thioredoxin	unknown	unknown	gnl\|CDD\|239245
NZ_CP018188.1\|WP_156247163.1\|109690_110698_+\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|377346
NZ_CP018188.1\|WP_070578325.1\|99970_100603_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018188.1\|WP_156247153.1\|100596_101289_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018188.1\|WP_125411933.1\|111350_111641_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018188.1\|WP_156247156.1\|103116_104010_+\|ribonuclease-D	unknown	unknown	unknown
NZ_CP018188.1\|WP_156247154.1\|101555_101741_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP018188.1\|WP_156247167.1\|113424_113868_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	0.000774469
NZ_CP018188.1\|WP_156247163.1\|109690_110698_+\|single-stranded-DNA-binding-protein	gnl\|CDD\|377346	pfam04404, ERF, ERF superfamily. The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to ERF.	1.44466e-13
NZ_CP018188.1\|WP_156247220.1\|97744_98653_+\|hypothetical-protein	gnl\|CDD\|379384	pfam13814, Replic_Relax, Replication-relaxation. This family includes proteins which are essential for plasmid replication and plasmid DNA relaxation.	0.000700608
NZ_CP018188.1\|WP_156247152.1\|99173_99971_+\|thioredoxin	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	8.618e-06
NZ_CP018188.1\|WP_156247162.1\|108787_109636_+\|hypothetical-protein	gnl\|CDD\|378917	pfam12684, DUF3799, PDDEXK-like domain of unknown function (DUF3799). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 265 and 420 amino acids in length. It appears that these proteins are distantly related to the PDDEXK superfamily and so these domains are likely to be nucleases. This family has a C-terminal cysteine cluster similar to that found in pfam01930.	1.09648e-66
NZ_CP018188.1\|WP_156247165.1\|112211_112868_+\|DNA-repair-protein-RadC	gnl\|CDD\|178801	PRK00024, PRK00024, DNA repair protein RadC.	6.43821e-45
NZ_CP018188.1\|WP_156247161.1\|108285_108714_+\|single-stranded-DNA-binding-protein	gnl\|CDD\|180915	PRK07275, PRK07275, single-stranded DNA-binding protein; Provisional.	1.85137e-50

>NZ_CP018188.1|WP_156247158.1|105369_106662_+|hypothetical-protein
MYTLEIPLNTKGYDDFLAKRFKYGYKLKRAVTNWINCQEHRRVSSEEYKSLSIRTKQLAELKEAISKEKDKTKKLSMKETHKELSATLKADWIALNDRFGLNSGKFIRYKELGQATAMYKRYAEEGIIHWSTMEIIAQTVKGAYLQRRKQGESSNHVSIGRLTNFTTLWYRKCNNNVTDEGVFFETGKGRNDKLFIPFAFRREQEIKVAYALEFPKLALYAIKRTLVKGNIWKYSILLVFDGVPYGLDHELPNKGNVEIKLSVEQMAITAARDNETIVYDLSNDFGYSKRLADLDRAIESKRQALNPDNYDENGVPKKGKRAWVQDSAYKKLLDQKRYIWHKVKQARKNRFGRIANQILMLGDTFTLYQEDFKSLQSRKDYNPEEMSWFDHRKQKGFEIMFNAPYEFVAILENKLSFKDLKLNKIKHKKK
>NZ_CP018188.1|WP_156247157.1|104316_105045_+|hypothetical-protein
MEIIKDNLKRCDAFYKSDFYQFLENHHPNYIPYLFDHLCGDPDARDVSLYQDLSKKFQLSARKDHLIDLVEGRKIRLAADIICGRKQIADFHNNDYEKWRKDYELVRSNLNLHFLWPKHKAPTINTYRYTKYLDRIDCLLFDLKSYFRGQETPMMAAYQSEETYIWLRQFNRDFKYFIDKMKLQAFVNDNYDVLDISTGQTEIIRDIISRKEISETLNLYMESLLKLNRQNVFNKECPPIQD
>NZ_CP018188.1|WP_156247156.1|103116_104010_+|ribonuclease-D
MNFVARINLKTDTPYREELIDFCLKGKQQYLAIGWSRIYGEGEALTYSEFYERLRQEPGRLNTVLNIFKDTHEDNLFWTRDLDGNYWICRAKGEVLTRCDKRLDIGALLPIDAYKFGMQVPGQIKAAFNRANAGTAQKIYDAIIVEYSKAIYNKLSQTNHYDVARLEGSLLDNLPDFDLEELVISYIQVKQDYYVLSNSIASKSTTIKVECEFLSRDPKRVRKAVVQVKGRKAEALDALQFTDFTQNGYEVFLFAPEVLNADKVDNIVVITPNELIDFYENYKVILPDSITQWENLY
>NZ_CP018188.1|WP_156247155.1|102415_102961_+|hypothetical-protein
MIDINEYPNAIDKVIKKSLILKEAMQLFPKLVTVYEFVNNRALSYGWRFGFQNQKFATSEINLELVGRINKELALRKSYLKRFISNREIEEVVFLQDLREGLIGGTISEGVDQLGFYPLEPITFEEEIPFYWPRFILFGQRVRRLKAYGYPLIENETTNTYLDFVTEVLSVYDEATGSDLI
>NZ_CP018188.1|WP_156247154.1|101555_101741_+|hypothetical-protein
MRRGEKMNLWLILILLGVVAVIGGGVAAAIGFGRHQKRANERAIREALELATKDRTQREQE
>NZ_CP018188.1|WP_156247153.1|100596_101289_+|hypothetical-protein
MLAYVIMFVVMFAIKCVTLTFVKNKESTVVSTFLSGTNQIFLNTIVWFLRLTAMFQFYLLVVDNNLTVTPIIVGFILPNVLFLFKGIKASLSDLLVRWLKSFIGHKYRTCPFCHESHLFFRYTEDRTAAYYYLLTEEDSLVAIGDFDNSDHPARFFLSNDESHFDELVDTMLPYMLPGMEEVVYVGGRQQRLARELYCVDCQERVSEDSGVQFGEVLLSEHRHEDHKALV
>NZ_CP018188.1|WP_070578325.1|99970_100603_+|hypothetical-protein
MYLSKKDISEWIASLKVGDEVAIQITRMDGVIVSSERGIVDKWLGKRLIVVNGKHFVPSTGLRQSNAFVPGQKTIVEQLFPLDALLLDEEELAKRDTIIQKLKESAELLEHAQTYSSLVVSRVLRKLSVLDVGDVYDLNELRSSSNTEDLEDSALLDRRKLSEKKRCLKTLDRMLANLSQDNTLGAFKLISLLGDVASEFTDAENEVSEC
>NZ_CP018188.1|WP_156247152.1|99173_99971_+|thioredoxin
MKIKIESAWKTLCDAFPKLKDNPLYKGWYISYAILVTLSILTVVVVNHRVVYAFPFDWFGLLFGIILPWVLTTFYIVYQGVDHAHQFTSTKVVLGLFMLPVILIGFTSSYKNEYSYSNRMVTTVFDQELTQQSFHATKITSNQLDYFKEDNIIFPYKKNTDSEIYVFFRPDCPYCQKSIPVLNKSLTEKERNKIIYVNVLDESGKDLAKAMGVEKAATAVIYHKDMTSGGWSKRIERMAGGKHEAPRLDEDAIHDIVSVAKEETK
>NZ_CP018188.1|WP_156247151.1|98670_99033_+|hypothetical-protein
MDYLEYLGRRLVWLVVSLVVVIVVKRPRLLKGLALVSDEVIGKINYFIFLTIAWLVLVTYFILYLFTVVTFFLSWHSLTVNNVLEMILQTVLIIPTLYTLFVPHNEVIKKVDDFLSAKKE
>NZ_CP018188.1|WP_156247220.1|97744_98653_+|hypothetical-protein
MIKGIEKIRLLTTTTEYDRSVYSIVTNNLLGGKPQTVNIHDLETRRLVAKILNKLFVKNKDKSVYDLNIQVVFPISRVNLLMVPDAVIFVNDNPFFIEYDRATERQTILLSKIFGYAEEPAFENSSLFFVFESSRKDNTQVSKRLMNFLEYVNEVEVEGVTGYDMLKLKNISLFSQTTTNASDVIVEIIQEKMFSNHKDWCDCEAYDFSELHKIDYLVKEISEPLDDDKFQLSAIVETDSWELKEYPMIPMAYIKSDLIPHLTSLYEEFSIEYEHMIIVFPKEVLPEKIKLPFDDYFFIVYR
>NZ_CP018188.1|WP_156247159.1|107569_107890_+|hypothetical-protein
MRNSFKTSSTYRAARKQQMTASKNTFFDADGMVISASDWATLVLSGEVDPKTSWSNDNVKGKLERVSPRSHWTKKGFREYLGKSRYVSKQDTQAEVLEMMDLELVF
>NZ_CP018188.1|WP_156247160.1|107902_108271_+|hypothetical-protein
MRKSMTKKMRMVDTYSPKHFRTSSTYRAARKKQKTATRKSFFDAEGMMVSASEWATLVLSGEVNPKNSWSNDHVKGYIDYLSPRSHFTKKGYKEFCGKSHKFSDGLDEGEIVFLDIEVVAED
>NZ_CP018188.1|WP_156247161.1|108285_108714_+|single-stranded-DNA-binding-protein
MINKVILTGRLVDAPELRYTPSNKAVATARIACPRDYKNQNGERETDFISLVIWDKKAENFSNWIKKGYLVTVEGRLQTRSYENQQGQRVYVTEVNVSNFDNLQPRDHSNTSSQSPDFGPAEGGFPGGGEPLDASIFENIPF
>NZ_CP018188.1|WP_156247162.1|108787_109636_+|hypothetical-protein
MIEEVAILPPLTEDNYYQDRHYMSTSRFKEYIKCPLRQEVVDLGFLPEKTETESLLVGNYVHSYFENKEAHEAFLEMNQDKIISQRGKTAGQVKAPFKQADKMIAALEKEELFNRLYHGTDDEMVEKERIITGTLEGIPFKCKIDSLNLSGGYFIDLKTMESLQSEKYSTTLHRYTKSLLYNIVEYQYTLQMYVYQELLKQTYGYEFTPYIMAVSKEPVPDKELIMIDDTIIEMGRDIFYGHLEVLKDALAHKSVEGCGHCDYCLTNKSLVTAKTVAEFLQQ
>NZ_CP018188.1|WP_156247163.1|109690_110698_+|single-stranded-DNA-binding-protein
MTVNTETMVNEIIEAKVALAKAEMQLEWQKADQAKKDHSKQEPEVMAPLFEAWAKAQAEFESVTATSRVTFKNVDFKFAPLSEILGAVRPALNKHGLTLTQQTKHIPFGNANGLKVVTTLLHESGASYAIESVPVFYNVNDIKNLGAQVTYLRRYEVKTLLGIEADSEELDMDNVPNHSQSTQETGNYGSNHTYQSNAQARTPRKPTGARYGKSAKSASVAFSLSSSEQTSLSEVTSAANKVASESVSQATSEAEVATQTSETATLEPKGTKANVCNDDQLIQMVARGEEAAMSLGATESQLLEWSELGESKGLTVQLKALSDFVAKQRQQAQQQ
>NZ_CP018188.1|WP_125411933.1|111350_111641_+|hypothetical-protein
MAKVCTYLKNDGHKVRVGYVSLAGLEALDNRGVNTMSEAVPGKRVWLIVYDEDRPCKSYTNEDIHYYKEFVDLFSSRLKRRLYYEAMLNELTVLKT
>NZ_CP018188.1|WP_156247164.1|111694_112003_+|hypothetical-protein
MTKREKALWLQEHYKNYSLKWYLENDARLNAMFRKAYHRYMTDLNVRASKAQLSHIEDLGKRMREVYEDVYGTNFDSDCRLDRAETNRKVQAIRSMWVVAPA
>NZ_CP018188.1|WP_156247165.1|112211_112868_+|DNA-repair-protein-RadC
MTETITRRQVRHPKDFGDRELFKRAFTHWIPSEKVDALYSELQGDFKKVFKKVCELSIEELKHYGLTQRDAIAFLSMLELFKRSEGEEEKPTCVTGTGYFAQSIQKAYGHKKQEHLVVWYLDVHCNVIEERVVFIGSVHRSMACPREIFHYAVKNLARYVLVAHNHPSGSVFPSSNDINVTEALEDAAKLFEMEVLDHVIVTKDNYYSFRDNGRMRCF
>NZ_CP018188.1|WP_156247166.1|112883_113372_+|hypothetical-protein
MGNISNAFGKVTISAPTMSDIEVLVATHRVINEKAWIPTTLKGHPRKADCITTEEGLVSVTLPFTACGNWNIRENIDSFLTNILKQDTTLSDIPMSATFDYVDAESGVNFIYKATVMTRNVPGKGVTTELLTDEDLGDYSESYLKELEEAYDQELALGRLSI
>NZ_CP018188.1|WP_156247167.1|113424_113868_+|GNAT-family-N-acetyltransferase
MKETFFWNFSSDAISTLSDLTSEGFEVDWTVRSSSNAITSGFVIQGEVSGMIEFTPEPSDAYTFVHKLEVRMDKKNQGIAGLLLAHVAQDALNRGFEGVMMCLSKTALLDYYVRRYGCSRIANTNRVIFHTAACQLLIDRFLKEGVD

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP018188_1	1.1\|106852\|38\|NZ_CP018188\|CRISPRCasFinder	106852-106889	38	NZ_CP018188	Streptococcus salivarius strain ICDC2 plasmid, complete sequence	106852-106889	0	1.0
NZ_CP018188_1	1.1\|106852\|38\|NZ_CP018188\|CRISPRCasFinder	106852-106889	38	MN480762	Streptococcus salivarius strain NU10 plasmid pSsal-NU10, complete sequence	20713-20750	1	0.974
NZ_CP018188_1	1.1\|106852\|38\|NZ_CP018188\|CRISPRCasFinder	106852-106889	38	NZ_CP015284	Streptococcus salivarius strain ATCC 25975 plasmid, complete sequence	10429-10466	4	0.895

1. spacer 1.1|106852|38|NZ_CP018188|CRISPRCasFinder matches to NZ_CP018188 (Streptococcus salivarius strain ICDC2 plasmid, complete sequence) position: , mismatch: 0, identity: 1.0

tactaaaacttagaggaaggttaacctttaaagtacat	CRISPR spacer
tactaaaacttagaggaaggttaacctttaaagtacat	Protospacer
**************************************

2. spacer 1.1|106852|38|NZ_CP018188|CRISPRCasFinder matches to MN480762 (Streptococcus salivarius strain NU10 plasmid pSsal-NU10, complete sequence) position: , mismatch: 1, identity: 0.974

tactaaaacttagaggaaggttaacctttaaagtacat	CRISPR spacer
tactaaaacttagaggaaggttaacctttaaagtacaa	Protospacer
*************************************

3. spacer 1.1|106852|38|NZ_CP018188|CRISPRCasFinder matches to NZ_CP015284 (Streptococcus salivarius strain ATCC 25975 plasmid, complete sequence) position: , mismatch: 4, identity: 0.895

tactaaaacttagaggaaggttaacctttaaagtacat	CRISPR spacer
gactaaaacttagaggaagtttaacctttatagtacaa	Protospacer
 ****************** ********** ******

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

16965 : 82385

Streptococcus_phage(22.22%)

transposase,integrase

attL 22637:22654|attR 85593:85610

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_104021194.1\|16965_18258_-\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	2.1e-189	82.5
WP_156247110.1\|18341_19100_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_156247111.1\|19193_20267_-	tyrosine recombinase XerS	A0A1B1IQT7	uncultured_Mediterranean_phage	4.6e-09	30.4
WP_156247112.1\|20447_20939_-	hypothetical protein	NA	NA	NA	NA
WP_156247113.1\|20952_21258_-	hypothetical protein	NA	NA	NA	NA
WP_156247218.1\|21326_21560_-	hypothetical protein	E4ZFJ0	Streptococcus_phage	3.8e-09	45.7
WP_118189730.1\|21589_21793_-	hypothetical protein	NA	NA	NA	NA
WP_156247114.1\|21822_22806_-	hypothetical protein	NA	NA	NA	NA
22637:22654	attL	NA	NA	NA	NA
WP_156247115.1\|22798_24229_-	hypothetical protein	NA	NA	NA	NA
WP_050088028.1\|26287_27529_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	G9I092	Helicoverpa_zea_nudivirus	8.1e-50	31.1
WP_156247116.1\|27512_29792_-	hypothetical protein	NA	NA	NA	NA
WP_156247117.1\|29883_30780_+\|integrase	tyrosine-type recombinase/integrase	S5W9T9	Leptospira_phage	3.6e-15	36.1
WP_156247118.1\|31170_31929_-	toxin PezT	NA	NA	NA	NA
WP_049553660.1\|31928_32405_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_156247119.1\|32474_32747_-	hypothetical protein	NA	NA	NA	NA
WP_070839262.1\|33323_33704_-	hypothetical protein	NA	NA	NA	NA
WP_156247219.1\|33696_33948_-	hypothetical protein	NA	NA	NA	NA
WP_002886742.1\|36854_37616_+\|transposase	IS110 family transposase	Q9JMN8	Wolbachia_phage	9.4e-25	29.1
WP_045768432.1\|37635_38022_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_156247120.1\|39276_41070_-	ATP-binding cassette domain-containing protein	F2Y2R6	Organic_Lake_phycodnavirus	5.3e-18	29.6
WP_156247121.1\|41053_42862_-	ATP-binding cassette domain-containing protein	F2Y1V6	Organic_Lake_phycodnavirus	1.3e-08	22.4
WP_156247122.1\|42895_43885_-	hypothetical protein	A0A1V0SAV8	Catovirus	1.4e-07	39.6
WP_156247123.1\|43868_44726_-	hypothetical protein	NA	NA	NA	NA
WP_073951136.1\|44715_45381_-	hypothetical protein	NA	NA	NA	NA
WP_156247124.1\|45859_47116_+\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	1.4e-126	56.6
WP_156247125.1\|47427_48132_-	hypothetical protein	NA	NA	NA	NA
WP_050989614.1\|48199_48388_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_156247126.1\|48739_49534_+	helix-turn-helix domain-containing protein	G4KNM8	Staphylococcus_phage	1.1e-10	26.2
WP_002887188.1\|52776_53382_-	response regulator transcription factor	NA	NA	NA	NA
WP_156247127.1\|53362_54925_-	hypothetical protein	NA	NA	NA	NA
WP_156247128.1\|54964_56872_-	FtsX-like permease family protein	NA	NA	NA	NA
WP_002892541.1\|56873_57611_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	5.7e-27	37.1
WP_156247129.1\|57607_59776_-	ATP-binding cassette domain-containing protein	W8CYL7	Bacillus_phage	1.3e-23	25.0
WP_156247130.1\|59729_62564_-	salivaricin biosynthesis lanthionine synthetase SalM	NA	NA	NA	NA
WP_145517187.1\|62647_62803_-	type A2 lantipeptide	NA	NA	NA	NA
WP_156247131.1\|63362_68879_-	helicase	A0A248SL14	Klebsiella_phage	7.7e-201	31.0
WP_156247132.1\|68953_69301_-	hypothetical protein	NA	NA	NA	NA
WP_156247133.1\|69421_70969_-	hypothetical protein	A8ATM0	Listeria_phage	9.4e-56	32.2
WP_156247134.1\|71027_71597_-	hypothetical protein	A8ATL9	Listeria_phage	8.9e-12	44.0
WP_156247135.1\|71612_72437_-	competence protein ComGA	NA	NA	NA	NA
WP_156247136.1\|72426_73890_-	hypothetical protein	NA	NA	NA	NA
WP_156247137.1\|74027_74630_-	GTP pyrophosphokinase	Q0H269	Geobacillus_phage	7.4e-17	29.4
WP_156247138.1\|74662_75991_-	DUF3854 domain-containing protein	NA	NA	NA	NA
WP_118189708.1\|77745_78576_+	AAA family ATPase	NA	NA	NA	NA
WP_156247139.1\|78559_79084_+	hypothetical protein	NA	NA	NA	NA
WP_156247140.1\|79747_81211_+	RepB family plasmid replication initiator protein	C5J987	Streptococcus_phage	2.5e-05	28.4
WP_156247141.1\|81401_82385_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
85593:85610	attR	NA	NA	NA	NA

DBSCAN-SWA_2

107569 : 112868

Streptococcus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_156247159.1\|107569_107890_+	hypothetical protein	A0A286QQ64	Streptococcus_phage	3.2e-27	59.8
WP_156247160.1\|107902_108271_+	hypothetical protein	A0A286QQ64	Streptococcus_phage	1.2e-25	57.3
WP_156247161.1\|108285_108714_+	single-stranded DNA-binding protein	C5J996	Streptococcus_phage	3.1e-33	56.0
WP_156247162.1\|108787_109636_+	hypothetical protein	A0A1S5S8V6	Streptococcus_phage	4.4e-63	45.2
WP_156247163.1\|109690_110698_+	single-stranded DNA-binding protein	A0A1Y0T023	Pseudomonas_phage	2.4e-12	35.8
WP_125411933.1\|111350_111641_+	hypothetical protein	NA	NA	NA	NA
WP_156247164.1\|111694_112003_+	hypothetical protein	NA	NA	NA	NA
WP_156247165.1\|112211_112868_+	DNA repair protein RadC	A0A1B2LRS6	Wolbachia_phage	1.2e-12	29.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP018187

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP018188

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection