CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP046938	Pediococcus pentosaceus strain GDIAS001 chromosome, complete genome	3 crisprs	cas1,cas2,csn2,cas3,DEDDh,csa3,WYL,DinG	0	5	9	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP046938_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046938_1

466138-466635

Unclear

Consensus_repeat	Method
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	PILER-CR
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	CRISPRCasFinder
GTTTCAGAAGANTGTTAAATCAATAAGTTCAAGTAC	CRT

7 spacers

csn2,cas2,cas1,cas3

The CRISPR arrays of NZ_CP046938_1

>merge|NZ_CP046938|1|466138-466635|PILER-CR,CRISPRCasFinder,CRT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTACCTACCAGTCGCATATATCCATTGCTCTGGGGTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTACTAAAAATTTTGCAAATAGTGCTTCATCACTGTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTACAATTATAGTGTACGTGATGAACGATTTGTTGTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTACTGAACTAGTGGAATGGTTATCTGATATTTTGTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTACATAGTCCTTACGTGTTTGCTCTGGCAAGGTGTTTCAGAAGAATGTTAAATCAATAAGTTCAAGTACACGAATATTTAAGAATGCTGGTATGGGATTGTTTCAGAAGAATGTTAAATCAATAAGTTCAAGTACCGCCGTTATTAGCCCAGCCACCTGCTAAGTGTTTTAGAAGAATGTTAAATCAATAAGCCTAAAATT

>NZ_CP046938|1|1|466138-466569|PILER-CR
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	CTACCAGTCGCATATATCCATTGCTCTGGG
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	TAAAAATTTTGCAAATAGTGCTTCATCACT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	AATTATAGTGTACGTGATGAACGATTTGTT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	TGAACTAGTGGAATGGTTATCTGATATTTT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	ATAGTCCTTACGTGTTTGCTCTGGCAAGGT
GTTTCAGAAGAATGTTAAATCAATAAGTTCAAGTAC	ACGAATATTTAAGAATGCTGGTATGGGATT
GTTTCAGAAGAATGTTAAATCAATAAGTTCAAGTAC

>NZ_CP046938|1|1|466138-466635|CRISPRCasFinder
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	CTACCAGTCGCATATATCCATTGCTCTGGG
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	TAAAAATTTTGCAAATAGTGCTTCATCACT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	AATTATAGTGTACGTGATGAACGATTTGTT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	TGAACTAGTGGAATGGTTATCTGATATTTT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	ATAGTCCTTACGTGTTTGCTCTGGCAAGGT
GTTTCAGAAGAATGTTAAATCAATAAGTTCAAGTAC	ACGAATATTTAAGAATGCTGGTATGGGATT
GTTTCAGAAGAATGTTAAATCAATAAGTTCAAGTAC	CGCCGTTATTAGCCCAGCCACCTGCTAAGT
GTTTTAGAAGAATGTTAAATCAATAAGCCTAAAATT

>NZ_CP046938|1|1|466138-466635|CRT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	CTACCAGTCGCATATATCCATTGCTCTGGG
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	TAAAAATTTTGCAAATAGTGCTTCATCACT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	AATTATAGTGTACGTGATGAACGATTTGTT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	TGAACTAGTGGAATGGTTATCTGATATTTT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	ATAGTCCTTACGTGTTTGCTCTGGCAAGGT
GTTTCAGAAGAATGTTAAATCAATAAGTTCAAGTAC	ACGAATATTTAAGAATGCTGGTATGGGATT
GTTTCAGAAGAATGTTAAATCAATAAGTTCAAGTAC	CGCCGTTATTAGCCCAGCCACCTGCTAAGT
GTTTTAGAAGAATGTTAAATCAATAAGCCTAAAATT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046938.1\|WP_158190408.1\|475280_475712_+\|ComF-family-protein	unknown	unknown	gnl\|CDD\|223970
NZ_CP046938.1\|WP_158190405.1\|465436_466108_+\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd12218_csn2_CAS-II-A	gnl\|CDD\|213411
NZ_CP046938.1\|WP_002832859.1\|450747_452301_+\|glutamine-hydrolyzing-GMP-synthase	unknown	unknown	gnl\|CDD\|234614
NZ_CP046938.1\|WP_011673065.1\|454367_455024_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046938.1\|WP_002834469.1\|469877_471710_+\|APC-family-permease	unknown	unknown	gnl\|CDD\|372624
NZ_CP046938.1\|WP_158190403.1\|464251_465157_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851
NZ_CP046938.1\|WP_023440043.1\|466767_467418_-\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP046938.1\|WP_158190401.1\|456604_459139_+\|peptidase	unknown	unknown	gnl\|CDD\|341064
NZ_CP046938.1\|WP_002834470.1\|467914_469534_+\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
NZ_CP046938.1\|WP_158190406.1\|473035_473689_-\|YigZ-family-protein	unknown	unknown	gnl\|CDD\|224653
NZ_CP046938.1\|WP_099299887.1\|448800_450615_+\|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319774
NZ_CP046938.1\|WP_023440047.1\|475842_476397_+\|ribosome-associated-translation-inhibitor-RaiA	unknown	unknown	gnl\|CDD\|224461
NZ_CP046938.1\|WP_002834462.1\|476557_478918_+\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NZ_CP046938.1\|WP_158190400.1\|452889_453282_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046938.1\|WP_002834471.1\|467602_467887_+\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|178988
NZ_CP046938.1\|WP_158190402.1\|459188_459815_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370635
NZ_CP046938.1\|WP_158190404.1\|465134_465440_+\|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0206_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|226043
NZ_CP046938.1\|WP_158190407.1\|473721_475041_+\|DEAD/DEAH-box-helicase-family-protein	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|226583
NZ_CP046938.1\|WP_011673068.1\|471860_473021_+\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	unknown	unknown	gnl\|CDD\|133463
NZ_CP046938.1\|WP_002834477.1\|453444_453759_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379262

Protein	Function_ID	Function_description	E-value
NZ_CP046938.1\|WP_158190408.1\|475280_475712_+\|ComF-family-protein	gnl\|CDD\|223970	COG1040, ComFC, Predicted amidophosphoribosyltransferases [General function prediction only].	3.88162e-32
NZ_CP046938.1\|WP_158190405.1\|465436_466108_+\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213411	cd12218, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	2.76477e-76
NZ_CP046938.1\|WP_002832859.1\|450747_452301_+\|glutamine-hydrolyzing-GMP-synthase	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
NZ_CP046938.1\|WP_002834469.1\|469877_471710_+\|APC-family-permease	gnl\|CDD\|372624	pfam13520, AA_permease_2, Amino acid permease.	4.77235e-28
NZ_CP046938.1\|WP_158190403.1\|464251_465157_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.57386e-99
NZ_CP046938.1\|WP_023440043.1\|466767_467418_-\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	6.39146e-10
NZ_CP046938.1\|WP_158190401.1\|456604_459139_+\|peptidase	gnl\|CDD\|341064	cd09601, M1_APN-Q_like, Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1). This M1 peptidase family includes eukaryotic and bacterial members: the catalytic domains of aminopeptidase N (APN), aminopeptidase Q (APQ, laeverin), endoplasmic reticulum aminopeptidase 1 (ERAP1) as well as tricorn interacting factor F3. Aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease, preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is considered a marker of differentiation since it is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. ERAP1, also known as endoplasmic reticulum aminopeptidase associated with antigen processing (ERAAP), adipocyte derived leucine aminopeptidase (A-LAP), or aminopeptidase regulating tumor necrosis factor receptor I (THFRI) shedding (ARTS-1), associates with the closely related ER aminopeptidase ERAP2, for the final trimming of peptides within the ER for presentation by MHC class I molecules. ERAP1 is associated with ankylosing spondylitis (AS), an inflammatory arthritis that predominantly affects the spine. ERAP1 also aids in the shedding of membrane-bound cytokine receptors. The tricorn interacting factor F3, together with factors F1 and F2, degrades the tricorn protease products, producing free amino acids, thus completing the proteasomal degradation pathway. F3 is homologous to F2, but not F1, and shows a strong preference for glutamate in the P1' position. APQ, also known as laeverin, is specifically expressed in human embryo-derived extravillous trophoblasts (EVTs) that invade the uterus during early placentation. It cleaves the N-terminal amino acid of various peptides such as angiotensin III, endokinin C, and kisspeptin-10, all expressed in the placenta in large quantities. APN is a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs are also putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	0
NZ_CP046938.1\|WP_002834470.1\|467914_469534_+\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NZ_CP046938.1\|WP_158190406.1\|473035_473689_-\|YigZ-family-protein	gnl\|CDD\|224653	COG1739, COG1739, Uncharacterized conserved protein [Function unknown].	2.29082e-58
NZ_CP046938.1\|WP_099299887.1\|448800_450615_+\|heavy-metal-translocating-P-type-ATPase	gnl\|CDD\|319774	cd02079, P-type_ATPase_HM, P-type heavy metal-transporting ATPase. Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP046938.1\|WP_023440047.1\|475842_476397_+\|ribosome-associated-translation-inhibitor-RaiA	gnl\|CDD\|224461	COG1544, COG1544, Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis].	1.65368e-37
NZ_CP046938.1\|WP_002834462.1\|476557_478918_+\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NZ_CP046938.1\|WP_158190402.1\|459188_459815_-\|hypothetical-protein	gnl\|CDD\|370635	pfam09726, Macoilin, Macoilin family. The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.	0.000111755
NZ_CP046938.1\|WP_002834471.1\|467602_467887_+\|co-chaperone-GroES	gnl\|CDD\|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	1.22914e-44
NZ_CP046938.1\|WP_158190404.1\|465134_465440_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	2.37291e-28
NZ_CP046938.1\|WP_158190407.1\|473721_475041_+\|DEAD/DEAH-box-helicase-family-protein	gnl\|CDD\|226583	COG4098, comFA, Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair].	7.58411e-163
NZ_CP046938.1\|WP_011673068.1\|471860_473021_+\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	gnl\|CDD\|133463	cd06853, GT_WecA_like, This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate molecule and N-acetylglucosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylglucosamine precursor. WecA participates in the biosynthesis of O antigen LPS in many enteric bacteria and is also involved in the biosynthesis of enterobacterial common antigen. A conserved short sequence motif and a conserved arginine at a cytosolic loop of this integral membrane protein were shown to be critical in recognition of substrate UDP-N-acetylglucosamine.	1.04782e-84
NZ_CP046938.1\|WP_002834477.1\|453444_453759_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	2.57449e-08

>NZ_CP046938.1|WP_158190405.1|465436_466108_+|type-II-A-CRISPR-associated-protein-Csn2
MKITYKTHDNLEINSGQILILGTNSPTVYTDIIQGLQDENEKISIVDENYSALEIAHAIDWIGYVGTQNLVLTKYLRQIEKLFLQSVTDEQQNKIHDEINRIFNIVSEQLFLLDLPIEVNFDFDLKKLFKYCGIRFDPILISKPYGIIETIIKIHETSNLDSCIALTNVAHYLTSVEFEELSQLVKETNQKILLIEFTEIEEQNFYGNAEFYYIDTDFIDWHN
>NZ_CP046938.1|WP_158190404.1|465134_465440_+|CRISPR-associated-endonuclease-Cas2
MRLMIMFDLPVETAKQRKQYRQFRKSLINEGFLMIQYSVYVRVCVTKKSATLMENRIKTFLPENGTIQVLTLTEKQYNDMHFLVGDRVEDVRNNSDRTVIL
>NZ_CP046938.1|WP_158190403.1|464251_465157_+|type-II-CRISPR-associated-endonuclease-Cas1
MGWRSIIITQHAKLSYSSRTMIVQTNDGINQIPIDDISLLLISTTQAVITTALISELSKKNVKIIFTDDTHEPISENYGYYPNHRSAELLREQLNWEIGRSQVLWTKVVASKLINQINVLKLQNIKTSSLEDELNKLELNDITNREAVIARKYFPLLFEDGFSRRNGSVINTALNYGYSILLSTINQEIVSNGYLTYIGIHHDNEENQFNLASDLMEPFRPIVDFWLANKKFNEFTPDVKYGLVELLSLEIKYNGKNTLLRNAITVHVRNCLKYLSNKEQNIKIEMELLDEVPNHAVNDNV
>NZ_CP046938.1|WP_158190402.1|459188_459815_-|hypothetical-protein
MKKIASIALLALVPLTLASCGSGNQKSDSQSSNATSKTEKVSKKASSKASSKKDQEASSSSKANSDSSSSAKDDQTSSSVASASNSTSKASNSAISSSSKSENNHNSSNKTNSNNLSRADLTAAEQQNNHQPLADETIQTSEAAINLVKAKYGDKGWKVAYSSVGKSSPIYFHVTSDHDGSYYVYANGVVQNAGGDLSDHASEIQNIK
>NZ_CP046938.1|WP_158190401.1|456604_459139_+|peptidase
MAKITRLYDLFQPEHYDIFLDISRETKHFRGKTVIQGIAQQTEIALHQKDLEVKVVYVNDEKTPFEIDSANEVIRLQLSQAGNVTLTVEYEAELTDSMMGIYPSYYEVDGVQKQLVGTQFETTFARQAFPGIDEPEAKATFDLAIKYDEHDGETILSNMPEIKVVDGIHYFDTTVKMSTYLIAFAFGDLQSKMTKTTSGVQVGVFATKAHQAQELDFALNIAKRSIEFYEEFYHTAYPLPHSWQLALPDFSAGAMENWGLVTYREAYLLLDPKNTALETKQLVATVIAHELAHQWFGDLVTMQWWDDLWLNESFANMMEYVAIDAIEPDWHIWEMFQTSDVPAALQRDATDGVQSVHVQVQNPAEIDALFDGAIVYAKGARMLVMVRALIGDDALRTGLKQYFNNHQYGNAKGADLWAALGEAAGIDVGAIMHSWLEQPGYPVVNVEVVDGQLTISQQQFFIGEGQNEGRQWQIPLKGNYEVVPQILDQPTLSLGDYQQLRNENGQPFRLNVGNESHFIVHYAKDLLADILGALDQLGAIDQLQILQDLRLLAEGNQISYAEIVPLLEKFADSSSAVVNDVLYRLAGDLKKFVQPDSKEEANLQKLFNQLSAKQVQRLGWKPRAAESNDDQLTRPYVLGAALYAKNPEAILAAHELFEQNQNQLSNLSADIRSYVLSNEVKNFNNERLFNQLMEQYRQSTDPSYKADLSRALTATTDEKQIKAIIEKFEDASTIKPQDLRAWFRGLLANAKGQQLTWDWIRNDWKWLEDTVGGDMEFNTFITVIANIFRTPARLEEFKAFFEPKLQTPGLTREITMDIKVIEGRVRLIQAEKAAVNTAIEKIIA
>NZ_CP046938.1|WP_011673065.1|454367_455024_+|hypothetical-protein
MGIRIDITGKKFGKLVAKYPSGKAKNGNTKWHCVCECGQEKDVELQHLKSGGTKSCGNCSRMKYDLQGKRFARLTVLGRADKVSSNGNIYWLCRCVCGKMIEADSYRLRTGNVKSCGCLRKEKAAQTIRKNAATAEQIGNSNAFKDRNGNPVQAVNIGARNTSGVIGVSFDHPSQKWVARMMHKGDLVLNATFLDFEEAVEARRRVEHKYLKNLSRTN
>NZ_CP046938.1|WP_002834477.1|453444_453759_+|helix-turn-helix-transcriptional-regulator
MVKRFQFIRKNRKRKNLTIEQLAEKADVSIDLVARLERGEREDVSISKLESILHALDLELGDVFKHSKLDKKSDEFVRKFLKLDAETREKYTDIFLSIIDLKNE
>NZ_CP046938.1|WP_158190400.1|452889_453282_-|hypothetical-protein
MSNILISLLTLIAILFCWKSLYQNLARQIAGRKFYITKEYPTTYANAVDNLDHATIQFKKDGSIKYEVINDYSNDKWTINGHKVEMGNIADPDRTYIDLNDERQIDGHTFYEIKFEDDINIFQYFLVSEN
>NZ_CP046938.1|WP_002832859.1|450747_452301_+|glutamine-hydrolyzing-GMP-synthase
MANADLSNFDKIIVLDFGSQYNQLITRRIREFGIYSELLSHKITAEEIKKINPKGIIFSGGPNSVYDKDAFRIDPEIYKLGIPILGICYGMQLMTYNLGGRVEPADNREYGHADIDVTDDQAVMFKELPAKQTVWMSHGDLVREVPEGFKTVATSANCPIASMADDARKFYGVQFHAEVRNTQYGNEILRHFAFDVCEAKANWSMNDFIDMQVQQIRETVGDRKVLLGLSGGVDSSVVGVLLNKAIGDQLVCIFVDHGLLRKGEAKQVMDSLEGKFGLNIIKVDAQDRFLSKLAGVSEPEQKRKIIGNEFIQVFNDEAQKLKGIDFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMHFELIEPLRTLFKDEARDLGEKLGMPEDLVWRQPFPGPGLGIRVIGEITEDKLQIVRDSDLILREEIKKAGLDRDIWQYFTVLPGIRSVGVMGDGRTYDYTVGIRAVNSIDGMTADFARIPWDVLQKISVRIVNEVDHVNRIVYDITSKPPATVEWE
>NZ_CP046938.1|WP_099299887.1|448800_450615_+|heavy-metal-translocating-P-type-ATPase
MLLVAGTLTVIGWLMQHLADQGLIANGAYGIATLVAGLPIIFKAISALRARVMSIELLVSIAVVGAVAILEFEEAAMVTFLFAFGNFLEQRTLQKTHQAIQNLTEMQPTTATMVVDGQYQEVEIDEVDEGAVLVVRVGDQVPVDGGIISGSAEVDEALITGESKLVDKTTGDQAYMGSIVENGQILVQAQKVGEDTTFGKIIELVEEAQDNQAPMSKFIDRFAKYYTPFVLVVAILILLFTKNLRLAITILVLACPGALVIGAPVSNVAGIGRGAKAGILIKGGDVIDQLAQVDTILFDKTGTVTEGRPTVKSIKEYQEDHWLALAADLEKQTNHPLARSIVEYYEKRGQKTTADLNLPITTIKGIGIKSEYQGQTIWIGSRRVLTENQIELTTQQARDLQAIENDGQSVVLMTVDQKLVLMMGLVDQVRKGVKETFEKLKQSGIDKQWMLTGDNSVIAEKIAKTIGINQVEAQMLPEEKALFLEQLQNDGRHVLFVGDGINDSPSIAKANVGIAMGNGTDVAIETSDVVLIDSDFSNIQNARRVAKATMRNTMQNVGIAIGTVALLLIGVAYGWVNMASGMLFHEISILVVIFNAMRLLRMKF
>NZ_CP046938.1|WP_023440043.1|466767_467418_-|CPBP-family-intramembrane-metalloprotease
MKISKSSILTLITYLIIFLLPSILNVFINLGAGFIWVETVDYLIGALLLIFISSKTNEINHIESNRKSFLYAIAWGIIGTALVILLQFVISYITIIFGSNPTSQNTATLVTLAKTNPFFILAITVGAPIMEELVFRKVLFGNLSAMFGADSTLGFTVMAIISSLAFAFMHNDSHIFLYAAIGLLFCWLYKKTGRIQTSMIAHILMNSVVILPLVIK
>NZ_CP046938.1|WP_002834471.1|467602_467887_+|co-chaperone-GroES
MLKPLGDRVILEAKDEEEQTVGGIVLASNAKEKSQTGKIIAVGNGTVLDNGQTVPMNVKVGDTVVYDKYAGTEVSYEDKKYLVVHEKDLVAVVE
>NZ_CP046938.1|WP_002834470.1|467914_469534_+|chaperonin-GroEL
MAKEIKFSEDARTKMLKGVDKLADTVKSTIGPKGRNVVLEQSYGSPTITNDGVTIAKAIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVNEGMKNVTAGANPVGIRRGIEKATSKAVEALHKMSHEVKTKDDIAQIASISSANPEVGKLIANAMEKVGNDGVITIEESRGVDTTLDVVEGMQFDRGYMSQYMVTDNDKMEANLDNPYILITDKKIGNIQDILPVLQSVVEQSRSLLIIADDITGEALPTLVLNKMRGTFNVVAVKAPGFGDRRKEQLEDIAILTGGTVITDDLGLNLKDVTIEQLGQSNKVTVTKDDTTIVEGAGSQEQIAERVGIIKQQISETTSDFDKEKLQERLAKLSGGVAVIRVGAATETELKEKKYRIEDALNATRAAVEEGFVPGGGTALANVISDLEDVEAEGDEATGVNIVRRALEEPVRQIAENAGEEGSVIVTKLKGQKPGVGYNAANDEWVDMVEAGIVDPTKVTRSALQNAASVSALLLTTEAVVADLPEDNPAPAAPAPGMGGMM
>NZ_CP046938.1|WP_002834469.1|469877_471710_+|APC-family-permease
MFSYLKRILIGKPLKTLDESGQALTKFKALALLSSDALSSIAYGTEEILSVLIVLSAAATWYSIPIAGIVLVLLFAITVSYRQIIKAYPSGGGAYVVASKNWGTSAGLVAGGSLLVDYMLTVAVSVTSGTEAITSAIPALQKYHIAIAVLIVLGIMALNLRGLRESASFLTIPVYLFIVVISLMIVVGLYNIATGQVAYHAASAVGSAVPGMTFVIFLRALSSGSSSLTGVEAISNAVPNFKKPRRKNAAGTLAIMSLILASFFAGITFLAYYSGITPSSSQTVLSQIGVTIFGHGIFYYILQLSTALILAVAANTGFSAFPMLAYNLAKDKFMPHAYMDRGDRLGYSNGIISLAAGAIVLILIFGGQTGLLIPLYAIGVFVPFTLSQSGMIVHWKREGGKKWMINASANLLGALLSAVLVICLLFLHFSNVWPYFIVMPLLLRMFYKIRKHYDEVADQLRVIEKGKVNLHDYDGSTVIVLVSNVTQVTSGAINYARSIGDYVIAMHVSFDANPEKEHKTAMEFKAEYPDVRFIDIHSSYRSITNPTLRFCDVIARRAAERNYTTTVLVPQFVPRKPWQNILHNQTGLRLRASLNSRENIIVSTYNYHLK
>NZ_CP046938.1|WP_011673068.1|471860_473021_+|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase
MRFEIIVSLFATMIISAILTPFVRRISFKVGAIDKPTARRVNKVPMPTMGGLAIFIAFNFSLFFLLRNQIPNPQFYGIFFGECIILVTGIIDDIFELRPIQKMIGILLAALAVYLFANVRMTTLTFPFIGIVNFGWFSLPITLLWIAAITNAINLLDGLDGLATGVTIIALFTTGFTGLFFLPSTNIYIVIMIFTLVAAEIGFLPYNFFPARIYLGDTGALFIGFMISIFSLSGLKNATFITILIPVMILGVPLTDTVYAILRRLLNKESISHADKRHLHHRLMQMGLTHRQTVLVIYGISLIFSFIALLYPVSTLWGSVLLTIGILIGIEIFVEAIGLVGENRTPMLNWIRKLVRSNTSKVDSNEFKEENTLKDKVRTRSERHKK
>NZ_CP046938.1|WP_158190406.1|473035_473689_-|YigZ-family-protein
MKPILSVKESFKIEQDIKKSRFITRIIPIQSEEEANQLLTEIRIIEAKANHNCFAYILGDQQDIQRASDDGEPSGTAGAPILEVLKRENLTNVLIVVTRYFGGIKLGAGGLIRAYGSSTSLAVNNAALIQLVDQELLSIKLDYQNNDQLVYYLEQHHLNQLETEYTTQVTTTISISKEQLDPLKKELIGFFSGNVAFKDLGTERVQIPYQKNEDDND
>NZ_CP046938.1|WP_158190407.1|473721_475041_+|DEAD/DEAH-box-helicase-family-protein
MKEIEKQKYYGRLVLQPINAVPTDALDCRPAIVMKGNQIHCQRCGAITSSRDGALPDHQFYCRKCINLGRVSTLVQLATIPEPNNFVANQSYLEWPGKLTAPQARCSKAIINSIDQQQNRLLWAVTGAGKTEMLFPGINHALQEQKRICVASPRIDVVLELFPRFQEAFPQAKIALLHGRSPAPYEYTQFVLCTTHQLLRFYHAFDVLIIDEVDSFPYAMNPELHYATKQARKLQGSTIYLTATPDGKLLQQSRQAKLATSYLTRRFHGHPLPEIKVVSGQNWMKKLRKGRLPSPLSRFIKEQIQAQRQFLIFVPKIEVLPKVLEALQQAFPTVKVLTVHAADPERVAKVQMMRKQEIDALITTTILERGVTFPGIDVAVLGADDAVFSMAALVQIAGRVGRSPQRPKGTVLFICPMLNRNIKRAQAQIKFMNRKASEC
>NZ_CP046938.1|WP_158190408.1|475280_475712_+|ComF-family-protein
MRNFFQHYKFQGDYLLRKVFQDQFVNFIQKILKENELIVPIPVDESTMISRGFNQVTGLMEGLDWKDVLINQRSNDSLHQFQRSRRERLQQDSSFVLKSGCDISGEHILLVDDIYTTGATLRQARTTLLRNGATQVRSVTLCR
>NZ_CP046938.1|WP_023440047.1|475842_476397_+|ribosome-associated-translation-inhibitor-RaiA
MLDFNVRGENIEVTEAIRDYVEKRIGKIEKYFEQGANPKAHVNLKVYQDKTAKVEVTIPLPYLVLRAEETSPDLYASVDLVTDKLERQLRKYKTKINRKSRETGYKGVEIPSGDIVENEEETSQFDIVRTKQVSLKPMGSEEAILQMDMLGHNFFIYEDAESGSVDIVYRRRDGRYGLIESAND
>NZ_CP046938.1|WP_002834462.1|476557_478918_+|preprotein-translocase-subunit-SecA
MANILKKWVESDARELKRLGKKADKIEALKEEMEQLNDEKLKAKTTEFKERLQNGETLDDILVEAFAVAREAAKRVLGLFPFRVQLIGGMVLHGGNIAEMKTGEGKTLTATLPVYLNALGGKGVHVVTVNEYLAERDSSEMGELYKWLGLTVGVNSSEMTPDQKREAYNCDITYSTNSEIGFDYLRDNMVVYKEDMVQRPLNFALIDEVDSILIDEARTPLIISGQTEPTVTLYERADRYVKTLADGDYTIDWESKSISLTENGIRRAENFFKTDNLYDVENSALNHHIDQALRANYIMTKDKDYVVSDGEVLIVDSFTGRVMEGRRFSDGLHQAIEAKEHVEIQDGAKTMANITYQNLFRMYRKLSGMTGTARTEAEEFREIYNMEVTTIPTNRPVARDDRPDLLYPTLESKFKAVVKEIRDLHIKGQPVLVGTVAVETSEYLSRLLDREGIPHVVLNAKNHAREAEIVTNAGQKGAVTIATNMAGRGTDIKLGPGVVELGGLAVIGTERHESRRIDNQLRGRSGRQGDVGMSQFYLSLEDDLMIRFGSERIKDLLSRMKIADEDAVIRSGLISRQVESAQKRVEGNNYDARKNVLQYDDVMRAQREVIYAERQQVIMEETSLKDVLMPMVDRTIDRVVDAHTQKTQKNFDLETIVEFARTALVSDKDIHQADVEGMSAKEIKDYLKQLADQMYIEKEKALYDPAQILEFEKVVILRVVDQHWTDHIDAMDQLRQSVGLRGYGQLNPLVEYQQEGYRMFNEMITDIEYETTRLFMKSEIRQNLQR

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Crispr_ID: NZ_CP046938_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046938_2

681733-681838

Orphan

Consensus_repeat	Method
TTAGCTCAGTTGGGAGAGCATCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046938_2

>merge|NZ_CP046938|2|681733-681838|CRISPRCasFinder
TTAGCTCAGTTGGGAGAGCATCTGCCTTACAAGCAGGAGGTCACAGGTTCGAGCCCTGTATCCCCCATTATATTTTGAGCCGTTAGCTCAGTTGGTAGAGCATCTG

>NZ_CP046938|2|2|681733-681838|CRISPRCasFinder
TTAGCTCAGTTGGGAGAGCATCTG	CCTTACAAGCAGGAGGTCACAGGTTCGAGCCCTGTATCCCCCATTATATTTTGAGCCG
TTAGCTCAGTTGGTAGAGCATCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046938.1\|WP_002833902.1\|669927_670194_+\|phosphocarrier-protein-HPr	unknown	unknown	gnl\|CDD\|237503
NZ_CP046938.1\|WP_055126152.1\|672853_674029_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340844
NZ_CP046938.1\|WP_055126165.1\|687762_689229_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP046938.1\|WP_055126166.1\|689831_690464_-\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239486
NZ_CP046938.1\|WP_158190484.1\|666752_667115_+\|DUF1634-domain-containing-protein	unknown	unknown	gnl\|CDD\|377927
NZ_CP046938.1\|WP_002833897.1\|675108_676143_+\|flippase-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|377103
NZ_CP046938.1\|WP_158190486.1\|695866_696706_-\|NAD(P)H-hydrate-dehydratase	unknown	unknown	gnl\|CDD\|238576
NZ_CP046938.1\|WP_002833746.1\|690809_693227_+\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234743
NZ_CP046938.1\|WP_029257840.1\|667169_669389_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|223616
NZ_CP046938.1\|WP_002833901.1\|670193_671918_+\|phosphoenolpyruvate--protein-phosphotransferase	unknown	unknown	gnl\|CDD\|224006
NZ_CP046938.1\|WP_023440211.1\|669593_669782_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046938.1\|WP_055126169.1\|695124_695844_+\|16S-rRNA-pseudouridine(516)-synthase	unknown	unknown	gnl\|CDD\|211327
NZ_CP046938.1\|WP_002833906.1\|665907_666753_+\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NZ_CP046938.1\|WP_002833744.1\|689275_689839_-\|16S-rRNA-(cytosine(1402)-N(4))-methyltransferase	unknown	unknown	gnl\|CDD\|377744
NZ_CP046938.1\|WP_002833742.1\|686497_687688_+\|methionine-adenosyltransferase	unknown	unknown	gnl\|CDD\|235374
NZ_CP046938.1\|WP_060743448.1\|671990_672764_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP046938.1\|WP_088356044.1\|693430_695116_+\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|240529
NZ_CP046938.1\|WP_105766208.1\|674078_675095_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NZ_CP046938.1\|WP_023440216.1\|685593_686325_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046938.1\|WP_158190485.1\|683790_685524_+\|pyruvate-oxidase	unknown	unknown	gnl\|CDD\|213733

Protein	Function_ID	Function_description	E-value
NZ_CP046938.1\|WP_002833902.1\|669927_670194_+\|phosphocarrier-protein-HPr	gnl\|CDD\|237503	PRK13780, PRK13780, phosphocarrier protein HPr; Provisional.	1.69391e-54
NZ_CP046938.1\|WP_055126152.1\|672853_674029_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340844	cd03817, GT4_UGDG-like, UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.	1.38201e-136
NZ_CP046938.1\|WP_055126165.1\|687762_689229_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	3.38657e-64
NZ_CP046938.1\|WP_055126166.1\|689831_690464_-\|phosphatase-PAP2-family-protein	gnl\|CDD\|239486	cd03392, PAP2_like_2, PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	6.6583e-52
NZ_CP046938.1\|WP_158190484.1\|666752_667115_+\|DUF1634-domain-containing-protein	gnl\|CDD\|377927	pfam07843, DUF1634, Protein of unknown function (DUF1634). This family contains many hypothetical bacterial and archaeal proteins. A few members of this family are annotated as being putative transmembrane proteins, and the region in question in fact contains many hydrophobic residues.	3.62604e-28
NZ_CP046938.1\|WP_002833897.1\|675108_676143_+\|flippase-like-domain-containing-protein	gnl\|CDD\|377103	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region. LPG_synthase_TM is the N-terminal region of this family of bacterial phosphatidylglycerol lysyltransferases. The function of the family is to add lysyl groups to membrane lipids, and this region is the transmembrane domain of 7xTMs. In order to counteract attack by membrane-damaging external cationic antimicrobial molecules - from host immune systems, bacteriocins, defencins, etc - bacteria modify their anionic membrane phosphatidylglycerol with positively-charged L-lysine; this results in repulsion of the foreign cationic peptides.	8.50457e-33
NZ_CP046938.1\|WP_158190486.1\|695866_696706_-\|NAD(P)H-hydrate-dehydratase	gnl\|CDD\|238576	cd01171, YXKO-related, B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.	8.24183e-77
NZ_CP046938.1\|WP_002833746.1\|690809_693227_+\|leucine--tRNA-ligase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0
NZ_CP046938.1\|WP_029257840.1\|667169_669389_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl\|CDD\|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP046938.1\|WP_002833901.1\|670193_671918_+\|phosphoenolpyruvate--protein-phosphotransferase	gnl\|CDD\|224006	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism].	0
NZ_CP046938.1\|WP_055126169.1\|695124_695844_+\|16S-rRNA-pseudouridine(516)-synthase	gnl\|CDD\|211327	cd02553, PseudoU_synth_RsuA, Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RsuA makes psi516 in 16S RNA. Psi at this position is not generally conserved in other organisms.	4.8608e-88
NZ_CP046938.1\|WP_002833906.1\|665907_666753_+\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	1.61547e-34
NZ_CP046938.1\|WP_002833744.1\|689275_689839_-\|16S-rRNA-(cytosine(1402)-N(4))-methyltransferase	gnl\|CDD\|377744	pfam06962, rRNA_methylase, Putative rRNA methylase. This family contains a number of putative rRNA methylases. Note that many family members are hypothetical proteins.	3.74975e-74
NZ_CP046938.1\|WP_060743448.1\|671990_672764_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.68968e-24
NZ_CP046938.1\|WP_088356044.1\|693430_695116_+\|polysaccharide-biosynthesis-protein	gnl\|CDD\|240529	cd13124, MATE_SpoVB_like, Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins. The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	2.69501e-136
NZ_CP046938.1\|WP_105766208.1\|674078_675095_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	6.02596e-34
NZ_CP046938.1\|WP_002833742.1\|686497_687688_+\|methionine-adenosyltransferase	gnl\|CDD\|235374	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated.	0
NZ_CP046938.1\|WP_158190485.1\|683790_685524_+\|pyruvate-oxidase	gnl\|CDD\|213733	TIGR02720, Pyruvate_oxidase, pyruvate oxidase. Members of this family are examples of pyruvate oxidase (EC 1.2.3.3), an enzyme with FAD and TPP as cofactors that catalyzes the reaction pyruvate + phosphate + O2 + H2O = acetyl phosphate + CO2 + H2O2. It should not be confused with pyruvate dehydrogenase [cytochrome] (EC 1.2.2.2) as in E. coli PoxB, although the E. coli enzyme is closely homologous and has pyruvate oxidase as an alternate name. [Energy metabolism, Aerobic].	0

>NZ_CP046938.1|WP_002833897.1|675108_676143_+|flippase-like-domain-containing-protein
MSRRNKVVLAVMILAGIIIFGFSLRNVNLNQMARDVVHLNMWWLLVALGCIVLYLGLEAVATKMLIQSNGDRLSWRDAIRIPLIEQLFNGITPFSSGGQPAQLVALMQNGIEGGRASSVLLMKFVVFQSMVVINFIFSLLIGFQYLEEKIRFLSWFVLFGFLIHLAVIIGLLMIMYWHNFTKRLISAIFIPIKHFVSKERYTTWKVTLNEKVDSFYQESVRMKSQWRLLAKVALVTFLQLLFYYLIPYFILLALGKSDVNIVMVTCLHVLIFMVISLFPIPGGAGGAEYGFSVIFAQFVGNNSKLVLAMMIWRILTYYFGMFAGMVATVVKPHKVNRVKVVKNE
>NZ_CP046938.1|WP_105766208.1|674078_675095_+|glycosyltransferase-family-4-protein
MPIKVNMFSSASKVKGQGVGSAYEELIRLLKTHFPKQIDVSINKFTKADISHYHTIDPNFYLSTFSKKRGVKVGYVHFLPETIEGSLNIPQPFRSIFYKYIISFYKRMDHIVVVNPTFIDKLVAYGISRDIITYIPNFVRKNEFYRFTEANRDAVRERLEVNNRFTVLGIGQVQERKGVKDFIKLAENNPDKYFIWAGGFSFGRLTDGYADLKQVVDNPPRNLKFTGIVDRNALVEYYNAADLFLLPSYNELFPMSVLEAFSCGVPVMLRDLELYHSIIKGYYIPTQDYEDMNTQLKLVSEDKERLNKFKQLSDEASEEYSEDHLADIWLDFYSSLTK
>NZ_CP046938.1|WP_055126152.1|672853_674029_+|glycosyltransferase-family-4-protein
MNIGLFTDTYFPQVSGVATSIKTLRDQLEKQGHQVYIFTTTDPKVDTNVYERNIFRFTSVPFVSFTDRRIAVSGFIRAAQLAKELNLDIVHTQTEFSLGWMGKFVAKSLKIPLIHTYHTMYEDYLHYVANGKLLKPYHVKQMTRAFCYHIDGIVAPSERVLDTIEGYGINVPIRVIPTGVNLEQYQKPNKRKQWREKLGYDESSPILLSLSRLAYEKNIQEVIDSFPAILKEVPNAQLLIVGDGPARASLENQVHDLHLEDSVQFTGEINNDHVYGFYQLADLFVSASDTESQGLTYIEALASNLKVVAKSGPYTDELLDDISLGKVFNTEDQLVAAIKDYIEHPDAYNDPAPREKKLYEISADYFGKQVVDYYSSAISTHTDLELDEDSE
>NZ_CP046938.1|WP_060743448.1|671990_672764_+|alpha/beta-hydrolase
MKLKLKSGAQIFFEDEGQGTPILFLTGFGGNTEIWSGQVNFFLQRGYRVIRLDYLNHGQSDRVDGELQIGDLADEVLQLVDYLQLKEPIGIGNSMGAAVLWNIINLRGWDFLSKAIFVDQSPKMLNDQQWHLGFKNLAEDNFDEVMNEPIVRPAYKHIDDFVFKNSKAIDSAYPFSQPQNRALVKGHAKKDWRFVLEQATKPVLFIMGEKSPFFDSTKTAELSALNANITVNVMKNVGHIPMAEDPTEFNRLVLQFV
>NZ_CP046938.1|WP_002833901.1|670193_671918_+|phosphoenolpyruvate--protein-phosphotransferase
MAGTLKGIAASDGIAIAKAYLMVDPDLSFEKKNITDVDAEIKRLHDALEKSKEELSLIKAKAAENLGAEEAEVFEAHLTILSDPELIGNIEDKIKNDTINAEEATKEVTDNFISMFEAMTDNAYMQERAADIRDVTKRLMSHLLGVELPNPALIDSEVVIVAHDLTPSDTAQLDRRYVKGFITDIGGRTSHSAIMSRTLEIPAVVGSEKATTSVKQGEMMIVDGLTGDAIIAPTDDEIKAYQQKGEEFKAQKAEWEKLKNEKTVSKDGVHFDLAANIGTPDDLQGVLDNGGEAVGLFRSEFLYMNASELPSEDEQFEAYKKVVEGMNGKQVVVRTMDIGGDKELPYLPLPEEMNPFLGYRAIRISLDRTDLFRTQLRALLRASAFGKLAIMFPMIATVAEFKKARAIYDDERQKMVDAGQEVGEIQVGMMMEIPAAAMIADKLAKYVDFFSIGTNDLIQYSFAADRGNEKVSYLYQPYNPSLLRLIKQTIDASHAEGKWTGMCGEMAGDQIAVPILMGLGLDEFSMSATSILKTRSLMKKLTTDDMKKLAEKAVTEAETNEDVIKLVQETVDNI
>NZ_CP046938.1|WP_002833902.1|669927_670194_+|phosphocarrier-protein-HPr
MEKRDFHVIAETGIHARPATLLVQSASKFNSDIQLTYKDKSVNLKSIMGVMSLGVGQGADVTISADGDDEADAIAALEDTMKKEGLSD
>NZ_CP046938.1|WP_023440211.1|669593_669782_+|hypothetical-protein
MRDYLQLLNDLKDGSIKELKITAEEFQDFQPRFMEFPERKQVIGKADRGGVVVYHFERIKDK
>NZ_CP046938.1|WP_029257840.1|667169_669389_-|ATP-dependent-Clp-protease-ATP-binding-subunit
MLCQNCQKNEASIHLYTNVNGQRTEVNLCQNCYQLLKNQRNNNINRNGGARMAQDPFGFGNLDDIFRAMQGGNMGQPENLYGQQVPPTQPGGGNGSGGNPNNRGNGGSLLSQYGLNLTDLAKQGKIDPVIGRDSEIERVIEILNRRTKNNPVLIGEAGVGKTAVVEGLAQRIVEGSVPQKLVNKQIVRLDVVSLVQGTGIRGQFEQRMQQLMKEVQANKDMVVFIDEIHEIVGAGNAEGGMDAGNVLKPALARGDFQLVGATTLKEFRDIEKDAALARRLQPVQVDEPSEEEAIKILKGIQKKYEDYHHVHYTDDAIEAAVKLSKRYIQDRFLPDKAIDLLDEAGSKKNLTINIADPETIQKKIDEAEAQKKAALQSEDYEKAAYYRDQVSKLEKNKDGATSSEEQPTVTEEDMEKIIETKTDIPVGDLQKQEQEQLQNLSENLKDHVIGQDEAVDKISRAIRRNRIGLNGTGRPIGSFLFVGPTGVGKTELAKQLAQQLFGSKDSMIRFDMSEYMEPHSISKLIGSPPGYVGYEEAGQLTEQVRRHPYSLVLLDEVEKAHPDVMHMFLQILDDGRLTDSQGRTVSFKDTIIIMTSNAGTGDVQADVGFGAAAQGKTHSVLDKLGNYFKPEFLNRFDDIVEFQALTKENLMQIVDLMIADVNSMLATQGLHVDVTKPVEERLVDLGYNPKMGARPLRRVIQEQIEDRIADFYLDHPAEKQLNAKIKDDQIEITGAPKKD
>NZ_CP046938.1|WP_158190484.1|666752_667115_+|DUF1634-domain-containing-protein
MNAKKQEMQHVELVIGRVLQVGVYISALVILLGIGLWLFKNGSGYSGALPTRITPIFHGVLAFKPYAVLMFGIFLLILTPVLRVIVSIYAFAKEGDRLYMVITTIVLVILIIGMAIGYRG
>NZ_CP046938.1|WP_002833906.1|665907_666753_+|sulfite-exporter-TauE/SafE-family-protein
MASHLIILLLVGLMAGIFGAILGIGGGMIITPVLTVAMGLDIKYAIGASIIAVIATSSGATIAYLKDEMLNLRVAMFLEIATTVGAIVGAIMTGIFNSTVLFVLFGSFLVFSSWNMYRKLRRGGGEEGSTKNDRLANQLNLNGSYYDKALKKNVDYQVENVPGGSAVMFGAGLASGLLGIGSGAFKVMAMDNIMKMPLKPSSATSNLMMGVTAAASAMVYFFNGSIHADIAGPLAIGILFGAQLGSRIMQHLQPRWIRMIFIPVLLYMGLQMILKGFGVNI
>NZ_CP046938.1|WP_158190485.1|683790_685524_+|pyruvate-oxidase
MTEKINASDAMIKVLESWGVHNVYGLPGGSFDSTMNALYNRKSTINYVQVRHEEVGALAAVGEAKVTGKLGVTFGSAGPGAVHLLNGLYDAKHDHMPVLALVGQVPTTLMNTDYFQELNENPIFTDVAVYNRTVMTAEQMPHVVDEAIRQAYKYSGVAVVTIPKDLGWQPIEDNYVSSANLYQAPILPEPDVKQVDEALEILSNAKHPVMYIGQGTRGAGSDIIALSEKLHIPIVTSALAKGIVPDSYKANMGSAGRVATKPGVEVLQAADAVMFVGSDFPFQPYFVAPDAKYIQVDIDASKFGRRHVVDLAILTDSHKFLKVMLEKAETTAESKWYKAALENKKNWEEWKNSFVGQQDTPLNVENVFAKINALATDDAIFQVDVGNVTIDGMRFLKADQAQRFTTSGWYATMGYALPAALGAQAEYPDRQVWSISGDGGYAMVMQDVLTQVKYHMPIINVILTNESLGFIEAEQDDSKQPHSGVDLIDADYGTSAQALGAEGFEVRTYDELEQAFEKAKDRKGPVVIDVKITNLRPLPVEQLLLDKETQDPEAVEQFVKKYHAESLIPFRKLLEEA
>NZ_CP046938.1|WP_023440216.1|685593_686325_-|hypothetical-protein
MNKINLPKFNYPIEKKSYLPAINALLLSVVPWYLSSHFSSEIFSKHLSIQILFFLATFMVNFLTIDRLTNKTNLRLMAPLAIIPILTFIILLFSENTYVALLGLLSFVPFLTTFLPFEQKNGVGLLTFSLSVGTLAPLAFFYIRNGFVTSILLKMGLLLSLMIIVILFAIFIKTSFKFAIFALALTLIITIFAFILLKSWTALIYPILAVFSWFIPKLHLPRNFTLLVLIALIGLASFFITIN
>NZ_CP046938.1|WP_002833742.1|686497_687688_+|methionine-adenosyltransferase
MSERHLFTSESVSEGHPDKIADQISDSILDELLKNDPDARVACETTVTTGLVVVVGEISTTAYIDIQKVVRKTIKDIGYVGGEYGFDGENCAVIVAIDEQSPDIAQGVDDSLETREGHEDRLNQIGAGDQGLMFGYATNETEELMPLPIMLSHHLMQRIAKLRKEQVISYLRPDAKAEVTVEYDDNDHPVRVDTVVLSTQHDPDVTLEQIRQDVIEQVIKAVIPATLLDENTNFYINPTGRFVIGGPQGDAGLTGRKIIVDTYGGAARHGGGAFSGKDATKVDRSASYAARYIAKNIVAAKLAERVEVQIAYAIGVAEPVSVMVDTFGTGTVSEEKLTQAVRKIFDLRPAGIIEMLDLKRPIYKQTAAYGHFGRTDVELPWEKTDKVEALNDFFKN
>NZ_CP046938.1|WP_055126165.1|687762_689229_+|MFS-transporter
MEKKQTNVIVVTVAIFVATFMSAIEGTIVSTAMPTIVGDLHGVSLMNWVISIFLLTNAIFTPIYGKLSDIFGRKRVFIFGIIIFLIGSMLSGMAHSMGFLILWRALQGIGAGSIMPVSNTIIADIYPIEKRAKVMGLNGSAWGIASIIAPLLGGFIVDNLSWHWIFFINLPIGIITIFLIQFFLKEEVSVHSKKIDYLGSFWLMVALLGLMYGFQLMGESSFSWITLVISFVIFIVGAGLFIRQEKRAEDPIIFLDLFNNRTFVIQNVATMLVSGLLIGFEVYLPSWTQGILGVPASLAGFAVTPSSILWIFGSFLAGRMIVKLKANQILTISLSILAVGSLLLALVPASTPFLAFFFIAAILGVGFGITITSTLVISQQLVTKDRIGVATSFNTLAKTLGQTIMMSVFGIIMNGTMNAGVKANPKINMDMMNKVINPQTAKTLPETLLPTLRNVLYQALHNIYIGCFILIVVALIINAFDRRSKDNI
>NZ_CP046938.1|WP_002833744.1|689275_689839_-|16S-rRNA-(cytosine(1402)-N(4))-methyltransferase
MLDNAMQYSHQLLTEIVQPGDVVIDATMGNGHDTLFLSELVQSTGRVFSFDVQKAALEQTRALFEHQHQTLINVELIHASHDQIDHYVTEPITGAIFNLGYLPGGDKSIITHPTSTISAVQQSLNQLKIGGRIILVCYYGHPGGQEELQQLLSFVAELDQHHYSCLRYEFINQINNPPILLCIERKK
>NZ_CP046938.1|WP_055126166.1|689831_690464_-|phosphatase-PAP2-family-protein
MHSRKYTHLLINILPTLLFILIVSLVIFKPSWVHAYDNSISSLVQSVRTPGFNQVVSIYTQLGNSIPYIIISLLVCSILILKHLKKAALFLACNIILGNGLNHLIKQIIQRQRPEFRLISIGGYSFPSGHSVAAMVLFGSLIFITFQVVHHQLKRNLLALIYLILMLGIGLSRIYLNVHFPTDVTAGFLLGLIVLQFTTYLFYGRKIKNA
>NZ_CP046938.1|WP_002833746.1|690809_693227_+|leucine--tRNA-ligase
MAYNHKDIEQKWQQFWSDNETFKTVEDADKPKYYALDMFPYPSGQGLHVGHPEGYTATDIMSRMKRMQGYKVLHPMGWDAFGLPAEQYAMKTGNNPRDFTAKNIQNFKRQIQSLGFSYDWSREVNTTDPAYYKWTQWIFEQLYKKGLAYEKETLVNWAPDLMGGTVVANEEVVDGKTERGGFPVYRKPMKQWILKITAYADRLIDDLDLVDWPDSIKEMQKNWIGRSVGASVFFNVEDSEKQIEVFTTRPDTLFGATYLVISPEHDLVDQITTPESKAAVEEYKKAVATKSDLERTDLNKDKTGVFTGAYAVNPVNGKKIPVWISDYVLASYGTGAVMAVPAHDGRDYEFAKKFKIDMVPVYEGGNLEDGVLDSEGGLINSGFLDGMDKQTAIDTMISWLEEHGVGHKKVNYRLRDWVFSRQRYWGEPIPVIHWEDGETTLIPEDELPLRLPAATDIRPSGTGESPLANLDDWVNVVDENGRKGRRETNTMPQWAGSSWYFLRYVDPKNDQKIADEDLLKEWLPVDLYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPFQKLVNQGMILGSNHEKMSKSKGNVVNPDDIVERFGADTLRLYEMFMGPLTESVAWSEDGLNGSRKWIDRVWRLMIDDENQLRDHIVTENDGSLDMIYNQTVKKVTDDYENMRFNTAISQMMVFVNEAYKADKLPAVYMEGLVKMLAPIIPHVAEELWSLLGHEGGISYAEWPTYDESKLVEATVQVILQVNGKVRSKITVDKDIAKEELEKLALADAKIQQWTADKTVRKVIVIPNKIVNIVVG
>NZ_CP046938.1|WP_088356044.1|693430_695116_+|polysaccharide-biosynthesis-protein
MDKQSEMDNSESLYMGSQPLRDNSGKSSSKAKMLEGSAWMTAGSIFSRILGAIYIIPWVIWFGVYSDQANALFTKGYNIYSFFLIAAIAGIPSAISKQVSHYNAINEFALGQRLYKRGLLLSVGTGIICAAILYFGAPFLKDGDPNVITVLHALAWAVLVIPTMSLTRGFFQGYQEMGPSAVSQFIEQLARVIYMLTTAYFIMGKSGQGDWVYGVSQSTFAAFIGALGGLLVLGIYFIKYRKRLSYLSQHSANELVVSTSTLYKEIIAQAVPFIIIGSAITIFQLIDQYTFFRIMNAVSDYSTAVLNNMYAIFAFNANKLVMIVISLASAMAVTSVPILSEAKTRGDRVEISRQVTDSILLFAFLMIPAALGMAAVAQPAYTLFYHLSDVGTAILQFNSYVAIVLGLFTVISAIMQGIGENVLAVKYFCVGMIVKFIFQFPMVALFSAVGSLISTAIGFMVVNWLILRHINLEYGLDYRRINTFIGKIITYAFGTFLIAMVVTNGLYIVMDPASKVQSLLVIAAAVVLGGAFYLYFVLKSRLADEIVGARAAGLRRMLKIS
>NZ_CP046938.1|WP_055126169.1|695124_695844_+|16S-rRNA-pseudouridine(516)-synthase
MRVDKFLHDMNMGTRTQIRKMIKDKLIFVNDTVVKTGRVKVDPVIDEVRLKDQVIEYQQYFYFMMNKPLGVLTATEDRKQKTVMDLFNKVDLRSDLFPVGRLDKDTQGLLLITNNGQLAHDLLAPERHVDKTYEAVVTGKITDQAVEEFQKGITLKDGTTLKPAQLIIEHYSELDDQTVVKVVLKEGKYHQVRRMFGSLGEKVVTLRRTSFGPLELDVGLLPGTYRELTDDEINRLVEG
>NZ_CP046938.1|WP_158190486.1|695866_696706_-|NAD(P)H-hydrate-dehydratase
MLKINQDGLNYLWPVRSNDSHKGSYGRILIVAGNDQYGGAGILSSSAAVYAGGGLVTLATDKSNFTAVRSTLAEVMLLDFLDFDALKAALKKSTGVVIGPGLGTNATSLKILKFVLDHVQPQTPLVIDGSAIDLIATHQIQVDHPQTIFTPHQMEWQRLSGIKIADQAPTLNQRAVDHLKAIVVLKHYETEIYAPHTDFRQIMAGNPGMATGGSGDALTGVIIALVNQVDSLALGVTLGTFLHSYTADQIYQKEAVVLPHRLICRLPFTLKQLQKNKLL

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Crispr_ID: NZ_CP046938_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046938_3

1754219-1754331

Orphan

Consensus_repeat	Method
TGACTTCCTGAATCTAACTGTTGAACGCC	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP046938_3

>merge|NZ_CP046938|3|1754219-1754331|CRISPRCasFinder
TGACTTCCTGAATCTAACTGTTGAACGCCGCTAATCAAGGTTCCTGTGCTTCCATTTAGAGTTTGAAGTCCGCTATTCAATGTGTGACTTCCTGAATCTAATTGTTGAACGCC

>NZ_CP046938|3|3|1754219-1754331|CRISPRCasFinder
TGACTTCCTGAATCTAACTGTTGAACGCC	GCTAATCAAGGTTCCTGTGCTTCCATTTAGAGTTTGAAGTCCGCTATTCAATGTG
TGACTTCCTGAATCTAATTGTTGAACGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046938.1\|WP_002834262.1\|1760044_1761850_-\|DUF2207-domain-containing-protein	unknown	unknown	gnl\|CDD\|378333
NZ_CP046938.1\|WP_029257587.1\|1763258_1764095_+\|manganese-catalase	unknown	unknown	gnl\|CDD\|252986
NZ_CP046938.1\|WP_158190931.1\|1751634_1752126_-\|nitroreductase	unknown	unknown	gnl\|CDD\|380313
NZ_CP046938.1\|WP_049752783.1\|1757197_1757701_-\|DUF1836-domain-containing-protein	unknown	unknown	gnl\|CDD\|378076
NZ_CP046938.1\|WP_036673200.1\|1746718_1747705_-\|lipoate--protein-ligase	unknown	unknown	gnl\|CDD\|161920
NZ_CP046938.1\|WP_002834186.1\|1745588_1746707_-\|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	unknown	unknown	gnl\|CDD\|213783
NZ_CP046938.1\|WP_158190932.1\|1752159_1752288_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380313
NZ_CP046938.1\|WP_002834184.1\|1744605_1745586_-\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
NZ_CP046938.1\|WP_002834261.1\|1758786_1759626_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|236841
NZ_CP046938.1\|WP_029257584.1\|1752547_1753183_-\|DUF4767-domain-containing-protein	unknown	unknown	gnl\|CDD\|374270
NZ_CP046938.1\|WP_158190933.1\|1764869_1766072_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_CP046938.1\|WP_029257582.1\|1749343_1750726_-\|glycoside-hydrolase-family-1-protein	unknown	unknown	gnl\|CDD\|225343
NZ_CP046938.1\|WP_002834259.1\|1757720_1758584_-\|DegV-family-protein	unknown	unknown	gnl\|CDD\|273257
NZ_CP046938.1\|WP_158190934.1\|1766752_1768183_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|129794
NZ_CP046938.1\|WP_002834191.1\|1750885_1751599_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NZ_CP046938.1\|WP_002834256.1\|1756785_1757106_-\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP046938.1\|WP_036673198.1\|1743299_1744613_-\|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl\|CDD\|237001
NZ_CP046938.1\|WP_011673871.1\|1747985_1749329_-\|PTS-sugar-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|224372
NZ_CP046938.1\|WP_002834264.1\|1761992_1763105_-\|low-temperature-requirement-protein-A	unknown	unknown	gnl\|CDD\|377704
NZ_CP046938.1\|WP_002834268.1\|1764147_1764873_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|376350

Protein	Function_ID	Function_description	E-value
NZ_CP046938.1\|WP_002834262.1\|1760044_1761850_-\|DUF2207-domain-containing-protein	gnl\|CDD\|378333	pfam09972, DUF2207, Predicted membrane protein (DUF2207). This domain, found in various hypothetical bacterial proteins, has no known function.	1.87483e-115
NZ_CP046938.1\|WP_029257587.1\|1763258_1764095_+\|manganese-catalase	gnl\|CDD\|252986	pfam05067, Mn_catalase, Manganese containing catalase. Catalases are important antioxidant metalloenzymes that catalyze disproportionation of hydrogen peroxide, forming dioxygen and water. Two families of catalases are known, one having a heme cofactor, and this family that is a structurally distinct family containing non-heme manganese.	2.01577e-119
NZ_CP046938.1\|WP_158190931.1\|1751634_1752126_-\|nitroreductase	gnl\|CDD\|380313	cd02136, PnbA_NfnB-like, nitroreductase similar to Mycobacterium smegmatis NfnB. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.	6.68812e-25
NZ_CP046938.1\|WP_049752783.1\|1757197_1757701_-\|DUF1836-domain-containing-protein	gnl\|CDD\|378076	pfam08876, DUF1836, Domain of unknown function (DUF1836). This family of proteins are functionally uncharacterized.	9.77839e-38
NZ_CP046938.1\|WP_036673200.1\|1746718_1747705_-\|lipoate--protein-ligase	gnl\|CDD\|161920	TIGR00545, Probable_lipoate-protein_ligase_A, lipoyltransferase and lipoate-protein ligase. One member of this group of proteins is bovine lipoyltransferase, which transfers the lipoyl group from lipoyl-AMP to the specific Lys of lipoate-dependent enzymes. However, it does not first activate lipoic acid with ATP to create lipoyl-AMP and pyrophosphate. Another member of this group, lipoate-protein ligase A from E. coli, catalyzes both the activation and the transfer of lipoate. Homology between the two is full-length, except for the bovine mitochondrial targeting signal, but is strongest toward the N-terminus. [Protein fate, Protein modification and repair].	7.17989e-88
NZ_CP046938.1\|WP_002834186.1\|1745588_1746707_-\|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	gnl\|CDD\|213783	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	9.17135e-159
NZ_CP046938.1\|WP_158190932.1\|1752159_1752288_-\|hypothetical-protein	gnl\|CDD\|380313	cd02136, PnbA_NfnB-like, nitroreductase similar to Mycobacterium smegmatis NfnB. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.	3.36265e-11
NZ_CP046938.1\|WP_002834184.1\|1744605_1745586_-\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	2.88289e-177
NZ_CP046938.1\|WP_002834261.1\|1758786_1759626_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|236841	PRK11088, rrmA, 23S rRNA methyltransferase A; Provisional.	4.37557e-40
NZ_CP046938.1\|WP_029257584.1\|1752547_1753183_-\|DUF4767-domain-containing-protein	gnl\|CDD\|374270	pfam15983, DUF4767, Domain of unknown function (DUF4767). This domain family is found in bacteria, and is approximately 140 amino acids in length. There is a single completely conserved residue Q that may be functionally important.	1.08832e-46
NZ_CP046938.1\|WP_158190933.1\|1764869_1766072_-\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	3.06482e-48
NZ_CP046938.1\|WP_029257582.1\|1749343_1750726_-\|glycoside-hydrolase-family-1-protein	gnl\|CDD\|225343	COG2723, BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism].	1.28378e-172
NZ_CP046938.1\|WP_002834259.1\|1757720_1758584_-\|DegV-family-protein	gnl\|CDD\|273257	TIGR00762, DegV, EDD domain protein, DegV family. This family of proteins is related to DegV of Bacillus subtilis and includes paralogous sets in several species (B. subtilis, Deinococcus radiodurans, Mycoplasma pneumoniae) that are closer in percent identity to each than to most homologs from other species. This suggests both recent paralogy and diversity of function. DegV itself is encoded immediately downstream of DegU, a transcriptional regulator of degradation, but is itself uncharacterized. Crystallography suggested a lipid-binding site, while comparison of the crystal structure to dihydroxyacetone kinase and to a mannose transporter EIIA domain suggests a conserved domain, EDD, with phosphotransferase activity. [Unknown function, General].	4.49622e-95
NZ_CP046938.1\|WP_158190934.1\|1766752_1768183_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	8.34448e-61
NZ_CP046938.1\|WP_002834191.1\|1750885_1751599_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	7.53435e-55
NZ_CP046938.1\|WP_002834256.1\|1756785_1757106_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	2.83874e-14
NZ_CP046938.1\|WP_036673198.1\|1743299_1744613_-\|2-oxo-acid-dehydrogenase-subunit-E2	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	2.39857e-159
NZ_CP046938.1\|WP_011673871.1\|1747985_1749329_-\|PTS-sugar-transporter-subunit-IIC	gnl\|CDD\|224372	COG1455, CelB, Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism].	2.22632e-117
NZ_CP046938.1\|WP_002834264.1\|1761992_1763105_-\|low-temperature-requirement-protein-A	gnl\|CDD\|377704	pfam06772, LtrA, Bacterial low temperature requirement A protein (LtrA). This family consists of several bacteria specific low temperature requirement A (LtrA) protein sequences which have been found to be essential for growth at low temperatures in Listeria monocytogenes.	1.87144e-45
NZ_CP046938.1\|WP_002834268.1\|1764147_1764873_-\|EAL-domain-containing-protein	gnl\|CDD\|376350	pfam00563, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.	3.15771e-22

>NZ_CP046938.1|WP_029257584.1|1752547_1753183_-|DUF4767-domain-containing-protein
MRHMKKPEKRSFGSINSVVWVILALIVVIAGYKFFYPNHVTNTTSSSDRSSSTKVIKVEEGKSSSSKAQSSSKKTKKTEKKIWTDKQDSELAAFISSWQQTMGQTYTGTNANASVSFDGVSFPDYLSKGQIYVNQQEVSMQWTRSEKADSEYKVVAVYTGDQYMYLFTFHNGQPEVLVTSQSASDGMNFKVTENADLVAEFQKVAAENTDK
>NZ_CP046938.1|WP_158190932.1|1752159_1752288_-|hypothetical-protein
MEVKQAIQKRHSVRHFTDQKIDSKQLKEIIGIAQKAPSWVNS
>NZ_CP046938.1|WP_158190931.1|1751634_1752126_-|nitroreductase
MKAIRKQQQELTITGAKTNSDIPPMSRKLWSEQAQKNMAEWSHGIPAVLGDNWQETLGKEASQLYNAQAVVYLTLPKGYTPWSLFDLGAFSKNILLATTEQGIDSIVAYNFVKYPQILREELKIPDDEEIIVGIGLGFEEEQAQVNRITSKRMDTESILKIKK
>NZ_CP046938.1|WP_002834191.1|1750885_1751599_+|GntR-family-transcriptional-regulator
MYKYEKISQAIRKQIIEQKIKPGALLPDQNQLAKEFNTTRITIGKALQSLIIEGLIYSKRGAGTFVRKDAHLNDEFTNDVDKPLGTTSTHPHSKVTSKYIHLTARIANEVEKKNLLLEDGETVYVIKRTRFIEGKAYSYEQTIMPTKIATITEEVLKKSIYQYLEHEYHLELAGSHRQITARKVSEEDAKFLGEKLGDPILVISQTSYLVDGTPFEFSESRFPYQSSAVSADVNLLE
>NZ_CP046938.1|WP_029257582.1|1749343_1750726_-|glycoside-hydrolase-family-1-protein
MKGKLPDNFLWGNSTSSMQTEGGVHEGGKGPSVYDTYEATETTSNWDVAIDNYHHYEEDLDLMANQGMNCYRFQISWSRVNPTGDGDFNEEGIQYYDRLINDLLKRGIKPMICLYHFDMPLHLAEKYNGFMSRHVVDAFVRFGKKMVDCFSDRVKLWVTFNEQNLYSQTEAFHIAGYLKGDQTDEELQLIAHHVMTAHAQVANYVHETSDAQIGGMLAYVESYPKNCRPRDVYVARQIDEFLNRNLLEVWVHGHYSTEVTQYIKNHHFDIDFTEQDQIAFEKLKSDFISFSYYASNVVDSTKIPQGTMPNRYLDYGGVENPYLKATDWGWNIDPLGFRDVITKTYNEYGIPMFPIENGIGYREIFDGTEIQDDYRIEYHRDHIQAMIDAVVEDGVPVLGYLGWGLIDIPSSSGNMEKRYGMVYVNRGNHELRDMKRVPKKSYKWFKKVIETNGNDLENDL
>NZ_CP046938.1|WP_011673871.1|1747985_1749329_-|PTS-sugar-transporter-subunit-IIC
MGSSNKESVNDKMQNSKFIAKFTEISVKVGNWVYLRSLRDAFAVILPMFIVAGIGVLLNNVVFTWFLSGDMLTKFQVIGNAIVNGTLNVAGILVAPMIGYSLARNKGFNNPIAAAAMSLASIFILMPGSIQLGTVASAGAKMATVTGGLSYLNTGTQGMFGGIFVGLIATGLFIKLASIKKLQIHLGENVPPAVSASFSVLIPAILLMSFFAIIAALLAGFFNTDLINLIKTWIQEPLRGFNTSIVGYCVIYTLANFLFGLGIHQTVLSGALLDPLVLVNMNENMTAYAHHQAIPNIITTSFVSNYTLIGGSGSTIALIIAILIFSKAKSSRQIAGLSLAPGIFNINEPMIFGFPIVFNLPLIIPFVLFPVVGSLMGYFATLWGWVSRTVVLVPWTTPPLIGPYLSTAGDWRAVILQILIIVVGVFLYLPFLKISERVSEIQAEENL
>NZ_CP046938.1|WP_036673200.1|1746718_1747705_-|lipoate--protein-ligase
MRYVTYMGTDAYTNIATDTWLLNNLNAKEPVFALWQNNNAIIVGQNQNTFGEVNQDFVDEHQIEVVRRVTGGGAVYHDLGNLNFTLFVPIESAANVDFKKFSEPVLRALHTLGIDAEASGRNDLLVNGKKISGVAQRYAKGYLMHHGTLLFDSNVDTMVRSLNVADEKFISKAAKSVRSRVGMIKDAAPKGLTLQDFWDAVQYELTDHGKDQEIVLTPQQKQEIIQLTADKFSTWDWNYGRSPEFNFKNHAKYDGGIIDVQVQAEGGTIRDINFTGDFLGLRDWREIKDQFIGLPFETAEIKTVFERNHEGRYFGNITDDELIKLFEA
>NZ_CP046938.1|WP_002834186.1|1745588_1746707_-|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha
MAVKDDNKQVLDFNLQMEKQTDSFPMLQVLNNDGEIVDEDALKEAGLNEDQLVELMKQMVFSRVLHERSTKLAKQGRLGFYAPTIGEEASQIASNYAFEKGDWLFPGYRDIPQLVMKGWPIYKAFLWSRGHYEGNEFDDVNGWMPQIIIGAQYVEAAGAALGLKMRKQPNVAYAYTGDGGTSQGDFYEGMNFAGAYNAPAVFFSQNNEYAISTPRKLQTKAPHLAAKGWAAGLPSLVVDGMDPIAMYLASKKARQWAVDGNGPVFIETITNRLGAHSMSGDDPLRYRTQEEIDEWTKKEPLIRFRKYLEGLGLWSEEIENDWTEVVNEQIDDGVKQADGIDKQKISDFIEQTLEVPGQAAQEQINKFRGEGK
>NZ_CP046938.1|WP_002834184.1|1744605_1745586_-|alpha-ketoacid-dehydrogenase-subunit-beta
MAQKTYIQAITEAQDLALANDENVVIFGEDVGKNGGVFRATDGLQAKYGEDRVFNTPLAESGIGGMAIGMTTQNYRPIMEIQFFGFVYEVMDSLAGQMARGRFRFHGTRTFPIVVRSPYGGGTKTPEMHADSLEGLVAQTPGLRVVMPATPADAKGLLLSAVESNDPVIFLENLRLYRSIRGDVPEGYYTTPLDKANVIREGKDVSIITYGGMVHTSLAAAEELAKDGIDAEVVDLRTVSPLDLDTIGESVEKTGRVVVAQEAQRQAGIGAMVMSEISERFIMSLKAPIGRVAAPDSVYPFALAENEWLPKADDIIEKVKEVVNFD
>NZ_CP046938.1|WP_036673198.1|1743299_1744613_-|2-oxo-acid-dehydrogenase-subunit-E2
MTEIFKMPDIGEGMAEGEIANWLVKVGDTIKEEDAVAEVQNDKLLQEILSPYGGKITKLFVEAGTVVKVGEPLIEFDGDGSGAGAESEAPKETPASTEPEPESSAPVDQTAPEVTKVGAEYTSNGQLLAMPSVREYARKNDIDLTQVPATGRHGHITMADVENFKASPASAPTASPAPAASVPETESEKAPSAPVTPAAPAEVKAGRVPLSPVRKVIAKTLTNQVQTIPHVTIMDEVEVSKLMDLRNQFKEQAKQKGYKLTYMPFIAKALAGAAHKYPELSAMVDIEKQEIVYYEDTNVSFAVDTDNGLFVPNVKNVKSKSIMEVAQEIDDMAIRGRAGDLKPNELKGGTVTITNIGSESGSGFFTPIINPGESAILGIGRIRKTPVVNEDGELAVGNTLKLSLSFDHRLIDGALAQKIMNELKALLSNPAYMLMEV
>NZ_CP046938.1|WP_002834256.1|1756785_1757106_-|winged-helix-turn-helix-transcriptional-regulator
MVKNNAALAAFKKNIPLLDALSDERRQQIMITLGESDAGLTVSELTKLIGLSQPAVSHHIKQLKDLSLVSVRKVGTSNIYQLTIKDALAQVQELIDILRKDKKLLR
>NZ_CP046938.1|WP_049752783.1|1757197_1757701_-|DUF1836-domain-containing-protein
MDSKQLENFAKMSLPKWDELPNIELHLDQVIDLANNYLRPLEVDLLTPTMMHNYLKQAVIIRPQGKLYGRMQLAAVIIIGCLKSILSLDEIKRGFEAELKLTSSRRAYNNFVNAFNEEVQRISQHGPRNLWNELLAETAVVSLQHSAIISMLTKKMAKDLLSDLEEK
>NZ_CP046938.1|WP_002834259.1|1757720_1758584_-|DegV-family-protein
MLKQKIAVLVDSCSDVPAEIANREYFEMIPMGVFFGEEEYQDRVNIEPDEFYQKLAKANPLPTTASPKGELITKALDNLSKRGFTQIIAVCISSGLSGTAQQVKIYAKNYPQLQIEVIDTKNIGIASGFAAVRASEVIEEGWEFNQIVEEVQRVANQTKVFFYVPTLKYLIAGGRIGRVAGLVGSIINLKPIISCDDEGIYYPVAKAHGEKKALKKMLQLVEDTLKNAQKFNLAVVHGLNEGLMNQISTEFKNKYPNMGKFYNGDISPALGVHTGPGLIGIGVQIIK
>NZ_CP046938.1|WP_002834261.1|1758786_1759626_+|methyltransferase-domain-containing-protein
MNKIELATQFIQRHLHQFQCPICKSNFNEVQSGTLICNNQHSFNIAKKGSLFFLNNPVNTEYTNEMLTYRNQFLTAGFFNPMLEEVINNISGDLILDAGCGEGTTTKWMASHFDGDFVGLDISKPAINIAGSGIAPQPYPLFMVGDLAQLPFADQGLTSIVNILSPANYQEFDRTLATHGELIKVIPGNHYLSELRQLVYPDGEHATYDNAPVKNHFIEHYEHVEFSKISYKFPLDDKLFTALFNMTPLTWQAQDRKEAILQDGLKEITAEFEIGVVRK
>NZ_CP046938.1|WP_002834262.1|1760044_1761850_-|DUF2207-domain-containing-protein
MKFFTKRTFLLLVTMLTFGIFWNVKTVKADYEISQFRMQINVNKDGSANINQSVLYDFDDDYHGVYLTQDLRGTAGAELEGITVSNNKGTQNQVPINNSGENLTAKVESSKKQMKIKVYNAVSSDDQTKITYHYRINGVVTNYKDTAEINWKVIGSGWDVPLEDAQVTIKLPGKNVKGLHAWSHGEAAGYTTVDKAKGKVTLDIGDNPENTFVEAHMVFPTALTPDNKKIVNQNHLAAVKKQEYQLVKRENEAQARARRIATYAKITSAIISVLILIGMMGWLKKHGYHQYDIPTPMEHSFDVPSISPAEAEALFNKSKADTKGVSAEMLVLAAEGKLKFKQIPYGKRGKETTEIERQGKFNMSFVDHCLDRIGDGQQVTIKQINDYAKKDKKNNVATWYKEWQSEVDTNLARFKDTYNISYRYGLLGLAIATPILAFIVGIIGRFGEATNLYWIGGIVLTLIIEAWVLATWDKVSMYNEAGLQQYNQIRGFKQMMKDIAHFNTAEIGDLILWEQILPYATAFGLAEKVAKKLKTDFGTQLNENVPFYAYYYGINGMHVGIANSISTSISHSVSASSSGSSGGFSGGSSGGFGGGSGGGAF
>NZ_CP046938.1|WP_002834264.1|1761992_1763105_-|low-temperature-requirement-protein-A
MKNELLKKVSMIELFYDLVFVYMISQVTGLIHHLQNGVISPSALSIFTLVVIVSINSWMVQTVFNNRYGKSQWSNVILSFVDMAIVLYMSNAFSDTFDRHLIGFFIAAGLLSLTLAIQYLLVFVQTKNEYDRNIAMAFMRILFFRTACLLAGGVLAGRWGTTIALFGIITSWIIPAFTGKHTQKHPIIFSHLLERLTALIIIMFGETIVGISKYFTQNTFSIQSIMIFIIVVSLFFTYIVEFDHLIEEQRTHETGNLLIYLHYFILFGLSLVTVALDFIHESEANAIFSITCLYVGIALFYIGIVIASYYNKTTLKLENYVVVAFIVVTLMGYFTSMCFATFSIIAGVTALTTLINAVVITLSLVRRYER
>NZ_CP046938.1|WP_029257587.1|1763258_1764095_+|manganese-catalase
MFKHQKELQFEAKPDRPDPIVAKYLQELIGGQYGEMSVAMQYLFQGWSCRGEEKYKDMIMDIATEEIGHVEMLATMVARLLEDAPIADQQAAMQADPTVGAIISGMNPQHAIVAGLGPRPADSVGNPWSGAYIIASGNLLADFRANLNAESQGRLQVARIYEMIDDQGVKDLLSVLLARDSYHQNLWASAVKELEEKEDSMLVPTTFPRDKERKDIAYDFYNFSQGDESSTGPWASGEALDGEGEYHWYDEPKVEGSAPNLKPVSPKMYGTPENKSEI
>NZ_CP046938.1|WP_002834268.1|1764147_1764873_-|EAL-domain-containing-protein
MSELEQKLEGICFYEQPIFLIDAAEKEEKKVIGSELLLRKTGGENRFPAMLYKEYMRDDASNLVFCTWLVKNIIEIINDNPGIQYSFNLDPQQLLYDSTFEAMKGLIPYCDRVMIEVTESIPSNRDIDQYFNYSVRDQIKRIHEMGFSVAVDDVSSGMNSFNAVREYTQDIDRLKLSLIQLRNVEEGMITVTISLWKALAANTGIDLVIEGIDSLEVSKWLLENGLEKQQGYYFATPRKLK
>NZ_CP046938.1|WP_158190933.1|1764869_1766072_-|diguanylate-cyclase
MENTVMNTIIYWAKGFFSFNTVVIAAITVGVLFMLAAGTYVVEMNMDKTKTSSTLIEELLWGVGLTIAMVFLQNVFTHLYSTIASSELGWKYSTAQFVVLFYCLYIVHRKVVLWFNIILPMYVYGLGIVRGQIGFDIAPILAILVIILISYTIYQQNDTLIDENVKYYSTLIMFGLAWWFVLKDIHHLTIVDIMCLTLEFLIAMSIVHFGNKKVRMIMKQYLNLMQEVDTDALTGVYNRNSFNKVVKGVFEFYSNNDAPLTMVMFDIDHFKQFNDQYGHQVGDKVLRLVADRFSYELVDRKAHGQLFRVGGEEFAIIFRGRTADDCEKIVRVIRDDLVKETIRVNNHDRVGIKVSIGISQLRDDDFDFQTFYKRVDDYLYQSKRNKRNSITVEGKVASLN
>NZ_CP046938.1|WP_158190934.1|1766752_1768183_+|DHA2-family-efflux-MFS-transporter-permease-subunit
MESTSFVNNPEIQKHRWWILIAVCSFTFMSTLDGSIVNIALPVMSSTMHVPMNKAEWVVSIYLIVICTLLLLFGKLGDAHGKIRVFKIGTMLFTIGSLLCGFNTGLTFLLIARIIQAVGAAMTMSTNNGIITEVSPAQERGRALGMIGSFVALGSIAGPGIGGLILAHFNWGYIFWINVPIGLLAILVGHKILPKDVIMTHQKIDKPGTILFAITMITLFVGISMGQEVGFTQPLILTMLFVALIALGTFLYVESHVETPILALYIFKNMRFTLSIICAFLIFITGFFFNVISPFYLENTLGLPANYAGYTLMIYPLINVVTAPVAGAISDKIGSEKLTFVGLLIILAAQLGYIVTNLATPLWLFMIFIGLNGLGNGIFQAPNNALVMGSVEPKDLGIAGGINSLARNLGMVVGISFATTVLFSAMSHIAGHSVTSVVPGHPEIFIAGMHVAFTVSFSVCLIATLITGYRLLRRQK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP046938_1	1.2\|466240\|30\|NZ_CP046938\|PILER-CR,CRISPRCasFinder,CRT	466240-466269	30	NZ_CP011159	Moraxella ovis strain 199/55 plasmid pMOV1, complete sequence	4814-4843	7	0.767
NZ_CP046938_1	1.2\|466240\|30\|NZ_CP046938\|PILER-CR,CRISPRCasFinder,CRT	466240-466269	30	NZ_CP018060	Moraxella catarrhalis strain CCRI-195ME plasmid unnamed, complete sequence	6514-6543	7	0.767
NZ_CP046938_1	1.2\|466240\|30\|NZ_CP046938\|PILER-CR,CRISPRCasFinder,CRT	466240-466269	30	NZ_CP026091	Ralstonia solanacearum strain IBSBF 2570 plasmid unnamed, complete sequence	1735846-1735875	7	0.767
NZ_CP046938_1	1.2\|466240\|30\|NZ_CP046938\|PILER-CR,CRISPRCasFinder,CRT	466240-466269	30	NZ_CP026093	Ralstonia solanacearum strain SFC plasmid unnamed, complete sequence	1735982-1736011	7	0.767
NZ_CP046938_1	1.2\|466240\|30\|NZ_CP046938\|PILER-CR,CRISPRCasFinder,CRT	466240-466269	30	NZ_CP012940	Ralstonia solanacearum strain UW163 plasmid unnamed, complete sequence	284760-284789	7	0.767
NZ_CP046938_1	1.2\|466240\|30\|NZ_CP046938\|PILER-CR,CRISPRCasFinder,CRT	466240-466269	30	NZ_CP012944	Ralstonia solanacearum strain IBSBF1503 plasmid unnamed, complete sequence	1616303-1616332	7	0.767
NZ_CP046938_1	1.2\|466240\|30\|NZ_CP046938\|PILER-CR,CRISPRCasFinder,CRT	466240-466269	30	NC_017575	Ralstonia solanacearum Po82 megaplasmid, complete sequence	1735519-1735548	7	0.767
NZ_CP046938_1	1.2\|466240\|30\|NZ_CP046938\|PILER-CR,CRISPRCasFinder,CRT	466240-466269	30	NZ_CP026308	Ralstonia solanacearum strain IBSBF 2571 plasmid unnamed, complete sequence	1735465-1735494	7	0.767
NZ_CP046938_1	1.2\|466240\|30\|NZ_CP046938\|PILER-CR,CRISPRCasFinder,CRT	466240-466269	30	NZ_CP051295	Ralstonia solanacearum strain CIAT_078 plasmid megaplasmid, complete sequence	282761-282790	7	0.767
NZ_CP046938_1	1.3\|466306\|30\|NZ_CP046938\|PILER-CR,CRISPRCasFinder,CRT	466306-466335	30	NZ_CP046163	Vibrio sp. THAF191c plasmid pTHAF191c_b, complete sequence	399991-400020	7	0.767
NZ_CP046938_1	1.3\|466306\|30\|NZ_CP046938\|PILER-CR,CRISPRCasFinder,CRT	466306-466335	30	NZ_CP046066	Vibrio sp. THAF191d plasmid pTHAF191d_b, complete sequence	584281-584310	7	0.767
NZ_CP046938_1	1.3\|466306\|30\|NZ_CP046938\|PILER-CR,CRISPRCasFinder,CRT	466306-466335	30	NZ_CP045356	Vibrio sp. THAF64 plasmid pTHAF64_a, complete sequence	1176529-1176558	7	0.767
NZ_CP046938_1	1.4\|466372\|30\|NZ_CP046938\|PILER-CR,CRISPRCasFinder,CRT	466372-466401	30	NZ_CP018299	Photobacterium damselae strain Phdp Wu-1 plasmid plas1, complete sequence	106150-106179	7	0.767
NZ_CP046938_1	1.5\|466438\|30\|NZ_CP046938\|PILER-CR,CRISPRCasFinder,CRT	466438-466467	30	MN850583	Escherichia phage glasur, complete genome	17970-17999	7	0.767
NZ_CP046938_1	1.2\|466240\|30\|NZ_CP046938\|PILER-CR,CRISPRCasFinder,CRT	466240-466269	30	MT601270	Bacillus phage vB_BsuM-Goe9, complete genome	7419-7448	8	0.733
NZ_CP046938_1	1.2\|466240\|30\|NZ_CP046938\|PILER-CR,CRISPRCasFinder,CRT	466240-466269	30	MT601270	Bacillus phage vB_BsuM-Goe9, complete genome	144282-144311	8	0.733
NZ_CP046938_1	1.2\|466240\|30\|NZ_CP046938\|PILER-CR,CRISPRCasFinder,CRT	466240-466269	30	KF669649	Bacillus phage CampHawk, complete genome	7103-7132	8	0.733
NZ_CP046938_1	1.2\|466240\|30\|NZ_CP046938\|PILER-CR,CRISPRCasFinder,CRT	466240-466269	30	KF669649	Bacillus phage CampHawk, complete genome	139524-139553	8	0.733
NZ_CP046938_1	1.6\|466504\|30\|NZ_CP046938\|PILER-CR,CRISPRCasFinder,CRT	466504-466533	30	MK496773	Capybara microvirus Cap3_SP_367, complete genome	1653-1682	8	0.733
NZ_CP046938_1	1.6\|466504\|30\|NZ_CP046938\|PILER-CR,CRISPRCasFinder,CRT	466504-466533	30	NC_022879	Enterococcus mundtii QU 25 plasmid pQY182, complete sequence	125872-125901	9	0.7

1. spacer 1.2|466240|30|NZ_CP046938|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP011159 (Moraxella ovis strain 199/55 plasmid pMOV1, complete sequence) position: , mismatch: 7, identity: 0.767

taaaaattttgcaaatagtgcttcatcact	CRISPR spacer
gaaaaattttgcaaataatgcttgctttat	Protospacer
 ****************.*****  *.  *

2. spacer 1.2|466240|30|NZ_CP046938|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP018060 (Moraxella catarrhalis strain CCRI-195ME plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.767

taaaaattttgcaaatagtgcttcatcact	CRISPR spacer
gaaaaattttgcaaataatgcttgctttat	Protospacer
 ****************.*****  *.  *

3. spacer 1.2|466240|30|NZ_CP046938|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP026091 (Ralstonia solanacearum strain IBSBF 2570 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.767

taaaaattttgcaaatagtgcttcatcact	CRISPR spacer
aaccgattttgcaaaccgtgcttcatcagt	Protospacer
 *  .**********. *********** *

4. spacer 1.2|466240|30|NZ_CP046938|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP026093 (Ralstonia solanacearum strain SFC plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.767

taaaaattttgcaaatagtgcttcatcact	CRISPR spacer
aaccgattttgcaaaccgtgcttcatcagt	Protospacer
 *  .**********. *********** *

5. spacer 1.2|466240|30|NZ_CP046938|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP012940 (Ralstonia solanacearum strain UW163 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.767

taaaaattttgcaaatagtgcttcatcact	CRISPR spacer
aaccgattttgcaaaccgtgcttcatcagt	Protospacer
 *  .**********. *********** *

6. spacer 1.2|466240|30|NZ_CP046938|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP012944 (Ralstonia solanacearum strain IBSBF1503 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.767

taaaaattttgcaaatagtgcttcatcact	CRISPR spacer
aaccgattttgcaaaccgtgcttcatcagt	Protospacer
 *  .**********. *********** *

7. spacer 1.2|466240|30|NZ_CP046938|PILER-CR,CRISPRCasFinder,CRT matches to NC_017575 (Ralstonia solanacearum Po82 megaplasmid, complete sequence) position: , mismatch: 7, identity: 0.767

taaaaattttgcaaatagtgcttcatcact	CRISPR spacer
aaccgattttgcaaaccgtgcttcatcagt	Protospacer
 *  .**********. *********** *

8. spacer 1.2|466240|30|NZ_CP046938|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP026308 (Ralstonia solanacearum strain IBSBF 2571 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.767

taaaaattttgcaaatagtgcttcatcact	CRISPR spacer
aaccgattttgcaaaccgtgcttcatcagt	Protospacer
 *  .**********. *********** *

9. spacer 1.2|466240|30|NZ_CP046938|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP051295 (Ralstonia solanacearum strain CIAT_078 plasmid megaplasmid, complete sequence) position: , mismatch: 7, identity: 0.767

taaaaattttgcaaatagtgcttcatcact	CRISPR spacer
aaccgattttgcaaaccgtgcttcatcagt	Protospacer
 *  .**********. *********** *

10. spacer 1.3|466306|30|NZ_CP046938|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP046163 (Vibrio sp. THAF191c plasmid pTHAF191c_b, complete sequence) position: , mismatch: 7, identity: 0.767

aattatagtgtacgtgatgaacgatttgtt	CRISPR spacer
cctcacggtgtacgagatgaacgatttggt	Protospacer
  *.*..******* ************* *

11. spacer 1.3|466306|30|NZ_CP046938|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP046066 (Vibrio sp. THAF191d plasmid pTHAF191d_b, complete sequence) position: , mismatch: 7, identity: 0.767

aattatagtgtacgtgatgaacgatttgtt	CRISPR spacer
cctcacggtgtacgagatgaacgatttggt	Protospacer
  *.*..******* ************* *

12. spacer 1.3|466306|30|NZ_CP046938|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP045356 (Vibrio sp. THAF64 plasmid pTHAF64_a, complete sequence) position: , mismatch: 7, identity: 0.767

aattatagtgtacgtgatgaacgatttgtt	CRISPR spacer
cctcacggtgtacgagatgaacgatttggt	Protospacer
  *.*..******* ************* *

13. spacer 1.4|466372|30|NZ_CP046938|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP018299 (Photobacterium damselae strain Phdp Wu-1 plasmid plas1, complete sequence) position: , mismatch: 7, identity: 0.767

tgaactagtggaatggttatctgatatttt	CRISPR spacer
acgagtcgtgaaagggttatctgatatttt	Protospacer
  .* * ***.** ****************

14. spacer 1.5|466438|30|NZ_CP046938|PILER-CR,CRISPRCasFinder,CRT matches to MN850583 (Escherichia phage glasur, complete genome) position: , mismatch: 7, identity: 0.767

atagtccttacgtgtttgctctggcaaggt	CRISPR spacer
ctttactttacgtgattgctctggcatggt	Protospacer
 *   *.******* *********** ***

15. spacer 1.2|466240|30|NZ_CP046938|PILER-CR,CRISPRCasFinder,CRT matches to MT601270 (Bacillus phage vB_BsuM-Goe9, complete genome) position: , mismatch: 8, identity: 0.733

taaaaattttgcaaatagtgcttcatcact	CRISPR spacer
taaaaattttgcaaaaagtacttgactttc	Protospacer
*************** ***.*** *.. ..

16. spacer 1.2|466240|30|NZ_CP046938|PILER-CR,CRISPRCasFinder,CRT matches to MT601270 (Bacillus phage vB_BsuM-Goe9, complete genome) position: , mismatch: 8, identity: 0.733

taaaaattttgcaaatagtgcttcatcact	CRISPR spacer
taaaaattttgcaaaaagtacttgactttc	Protospacer
*************** ***.*** *.. ..

17. spacer 1.2|466240|30|NZ_CP046938|PILER-CR,CRISPRCasFinder,CRT matches to KF669649 (Bacillus phage CampHawk, complete genome) position: , mismatch: 8, identity: 0.733

taaaaattttgcaaatagtgcttcatcact	CRISPR spacer
taaaaattttgcaaaaagtacttgactttc	Protospacer
*************** ***.*** *.. ..

18. spacer 1.2|466240|30|NZ_CP046938|PILER-CR,CRISPRCasFinder,CRT matches to KF669649 (Bacillus phage CampHawk, complete genome) position: , mismatch: 8, identity: 0.733

taaaaattttgcaaatagtgcttcatcact	CRISPR spacer
taaaaattttgcaaaaagtacttgactttc	Protospacer
*************** ***.*** *.. ..

19. spacer 1.6|466504|30|NZ_CP046938|PILER-CR,CRISPRCasFinder,CRT matches to MK496773 (Capybara microvirus Cap3_SP_367, complete genome) position: , mismatch: 8, identity: 0.733

acgaatatttaagaatgctggtatgggatt	CRISPR spacer
tagaatatttaataatgctggtagtgtagc	Protospacer
  ********** **********  * * .

20. spacer 1.6|466504|30|NZ_CP046938|PILER-CR,CRISPRCasFinder,CRT matches to NC_022879 (Enterococcus mundtii QU 25 plasmid pQY182, complete sequence) position: , mismatch: 9, identity: 0.7

acgaatatttaagaatgctggtatgggatt	CRISPR spacer
caaggggtttaataatgctagtatgggatt	Protospacer
  ... .***** ******.**********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

90591 : 96288

Staphylococcus_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_158190273.1\|90591_90951_-	helix-turn-helix domain-containing protein	A0A1J0MG99	Staphylococcus_phage	1.2e-19	70.1
WP_158190274.1\|91103_91313_+	DUF1870 family protein	A0A0N7GFI4	Staphylococcus_phage	2.4e-15	57.8
WP_158190275.1\|91359_92052_+	transcriptional regulator	A0A192Y918	Salmonella_phage	8.0e-23	35.4
WP_158190276.1\|92154_92427_+	DNA-binding protein	NA	NA	NA	NA
WP_158190277.1\|92588_92858_+	hypothetical protein	NA	NA	NA	NA
WP_158190278.1\|92844_93624_+	hypothetical protein	NA	NA	NA	NA
WP_158190279.1\|93620_95084_+	DNA primase	V5US55	Enterococcus_phage	1.8e-32	29.2
WP_158190280.1\|95697_96060_+	DUF1492 domain-containing protein	D2IYV6	Enterococcus_phage	1.8e-10	35.5
WP_002834405.1\|96072_96288_+	hypothetical protein	D7RWL9	Brochothrix_phage	4.2e-07	50.8

DBSCAN-SWA_2

478999 : 486617

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_158190409.1\|478999_480115_+	peptide chain release factor 2	B5LLF2	Mycobacterium_phage	1.9e-05	47.1
WP_002834460.1\|480126_480831_+	response regulator transcription factor	W8CYM9	Bacillus_phage	6.9e-38	37.3
WP_099299840.1\|480802_482188_+	two-component sensor histidine kinase	W8CYF6	Bacillus_phage	2.2e-27	33.8
WP_002834458.1\|482349_483231_+	phosphate ABC transporter substrate-binding protein PstS family protein	H6WG65	Cyanophage	9.3e-08	25.9
WP_158190410.1\|483230_484139_+	phosphate ABC transporter permease subunit PstC	NA	NA	NA	NA
WP_002834456.1\|484139_485027_+	phosphate ABC transporter permease PstA	NA	NA	NA	NA
WP_099299841.1\|485044_485845_+	phosphate ABC transporter ATP-binding protein	Q6GZ03	Mycoplasma_phage	3.4e-09	42.0
WP_023440049.1\|485858_486617_+	phosphate ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.7e-18	30.5

DBSCAN-SWA_3

774659 : 842185

Lactobacillus_phage(51.28%)

tail,capsid,holin,integrase,head,plate,terminase,tRNA,protease,portal

attL 785637:785661|attR 825109:825133

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_158190514.1\|774659_775349_+\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_002833522.1\|775381_775594_+	YqgQ family protein	NA	NA	NA	NA
WP_002833523.1\|775611_776574_+	ROK family glucokinase	NA	NA	NA	NA
WP_002833524.1\|776605_777025_+	rhodanese-like domain-containing protein	NA	NA	NA	NA
WP_002833525.1\|777078_777255_-	DUF3042 family protein	NA	NA	NA	NA
WP_055126203.1\|777337_778072_+	glycerophosphodiester phosphodiesterase	A0A0S2MYI4	Enterococcus_phage	1.2e-13	35.2
WP_158190515.1\|778073_779006_+\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_158190516.1\|778989_780246_+	aluminum resistance protein	NA	NA	NA	NA
WP_023440271.1\|780326_780692_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_002833531.1\|780726_782067_+	type I glutamate--ammonia ligase	M1NM71	Moumouvirus	2.5e-12	22.8
WP_002833532.1\|782215_783091_+	hypothetical protein	NA	NA	NA	NA
WP_002833533.1\|783083_784001_+	hypothetical protein	NA	NA	NA	NA
WP_002833534.1\|784010_784550_+	dUTPase	A0A290GJJ6	Caldibacillus_phage	9.7e-08	26.2
WP_002833535.1\|784853_785081_+	hypothetical protein	NA	NA	NA	NA
WP_158190517.1\|785220_785424_-	hypothetical protein	NA	NA	NA	NA
785637:785661	attL	NA	NA	NA	NA
WP_158190518.1\|785761_786910_-\|integrase	tyrosine-type recombinase/integrase	E9LUK6	Lactobacillus_phage	9.0e-88	48.2
WP_158190519.1\|787047_787938_-	hypothetical protein	NA	NA	NA	NA
WP_158190520.1\|788002_788410_-	ImmA/IrrE family metallo-endopeptidase	A0A0M7RF74	Lactobacillus_phage	6.8e-06	32.3
WP_158190521.1\|788419_788767_-	helix-turn-helix domain-containing protein	Q9T1J3	Lactobacillus_phage	4.1e-12	37.2
WP_158190522.1\|789024_789231_+	transcriptional regulator	NA	NA	NA	NA
WP_158190523.1\|789510_789774_-	hypothetical protein	NA	NA	NA	NA
WP_158190974.1\|790020_790746_+	phage regulatory protein	D2IYT0	Enterococcus_phage	3.0e-52	50.0
WP_011673226.1\|790748_791093_+	DUF771 domain-containing protein	NA	NA	NA	NA
WP_158190524.1\|791190_791415_+	hypothetical protein	NA	NA	NA	NA
WP_158190525.1\|791416_791644_-	hypothetical protein	NA	NA	NA	NA
WP_158190526.1\|791867_792329_+	chromosome segregation protein SMC	NA	NA	NA	NA
WP_158190527.1\|792328_793096_+	AAA family ATPase	B4XYS4	Lactobacillus_phage	1.4e-63	53.4
WP_158190528.1\|793095_793617_+	DUF669 domain-containing protein	A0A059T5G4	Listeria_phage	5.6e-29	43.3
WP_158190529.1\|793636_794470_+	hypothetical protein	A8YQM0	Lactobacillus_phage	2.7e-41	42.6
WP_158190530.1\|794453_795680_+	DNA helicase	A0A0P0IXJ2	Lactobacillus_phage	2.0e-61	37.2
WP_158190531.1\|795688_796105_+	hypothetical protein	NA	NA	NA	NA
WP_158190532.1\|796101_796644_+	hypothetical protein	A0A2P0ZKV6	Lactobacillus_phage	2.3e-25	48.4
WP_061812683.1\|796618_796837_+	hypothetical protein	NA	NA	NA	NA
WP_158190533.1\|796849_797077_+	hypothetical protein	NA	NA	NA	NA
WP_158190534.1\|797073_797211_+	hypothetical protein	NA	NA	NA	NA
WP_158190535.1\|797197_797392_+	hypothetical protein	NA	NA	NA	NA
WP_158190536.1\|797391_797931_+	DUF1642 domain-containing protein	A0A1S5SC90	Streptococcus_phage	2.3e-09	35.2
WP_158190537.1\|797923_798169_+	hypothetical protein	O03923	Lactobacillus_phage	8.5e-12	43.8
WP_158190538.1\|798161_798374_+	hypothetical protein	NA	NA	NA	NA
WP_158190539.1\|798385_798625_+	hypothetical protein	NA	NA	NA	NA
WP_158190540.1\|798617_798788_+	hypothetical protein	NA	NA	NA	NA
WP_158190541.1\|799107_799398_+	hypothetical protein	NA	NA	NA	NA
WP_158190975.1\|799531_799771_+	hypothetical protein	A8ASM5	Listeria_phage	1.1e-11	55.2
WP_158190542.1\|799773_799971_+	hypothetical protein	NA	NA	NA	NA
WP_158190543.1\|799970_800225_+	hypothetical protein	A0A2K9VD68	Lactobacillus_phage	6.7e-20	57.1
WP_158190544.1\|800230_800593_+	hypothetical protein	NA	NA	NA	NA
WP_158190545.1\|800668_801112_+	RNA polymerase subunit sigma-70	O03925	Lactobacillus_phage	2.2e-13	34.8
WP_158190546.1\|801410_801974_+	hypothetical protein	NA	NA	NA	NA
WP_158190547.1\|802059_802227_+	hypothetical protein	NA	NA	NA	NA
WP_158190548.1\|802228_802684_+	HNH endonuclease	B8R694	Lactobacillus_phage	2.8e-24	39.6
WP_158190549.1\|802680_802980_+	hypothetical protein	NA	NA	NA	NA
WP_094104463.1\|803198_803663_+\|terminase	phage terminase small subunit P27 family	E9LUP8	Lactobacillus_phage	1.5e-46	62.7
WP_158190550.1\|803662_805537_+\|terminase	terminase large subunit	A0A0M7RDK9	Lactobacillus_phage	2.6e-140	41.3
WP_158190551.1\|805737_806850_+\|portal	phage portal protein	Q9AZM4	Lactococcus_phage	4.0e-64	37.6
WP_158190976.1\|806833_807424_+\|head,protease	HK97 family phage prohead protease	A0A0M7RF71	Lactobacillus_phage	9.5e-41	49.5
WP_158190977.1\|807436_808747_+\|capsid	phage major capsid protein	D2KRA9	Lactobacillus_phage	1.7e-82	59.3
WP_158190552.1\|808829_809300_+	hypothetical protein	A0A1D6Z291	Staphylococcus_phage	3.4e-17	42.9
WP_158190553.1\|809315_809642_+	DNA-packaging protein	NA	NA	NA	NA
WP_158190554.1\|809616_809976_+\|head	phage head closure protein	A0A2P0ZLF0	Lactobacillus_phage	8.9e-18	41.2
WP_158190978.1\|809995_810391_+\|tail	phage tail protein	A0A286QQY0	Streptococcus_phage	3.3e-29	53.8
WP_158190555.1\|810390_810780_+	DUF806 family protein	A0A2P0ZLF4	Lactobacillus_phage	1.6e-12	30.3
WP_158190556.1\|810779_811388_+\|tail	phage tail protein	Q9AZL7	Lactococcus_phage	1.6e-35	41.6
WP_061812728.1\|811521_811935_+	hypothetical protein	NA	NA	NA	NA
WP_158190557.1\|812143_817276_+	peptidoglycan DD-metalloendopeptidase family protein	G7YZ66	Streptococcus_phage	9.3e-100	38.1
WP_158190558.1\|817291_818125_+\|tail	phage tail family protein	A0A0M7RF73	Lactobacillus_phage	3.0e-48	37.9
WP_158190559.1\|818054_819278_+	hypothetical protein	A0A0M7RDS2	Lactobacillus_phage	2.1e-74	43.6
WP_158190560.1\|819267_819582_+	hypothetical protein	NA	NA	NA	NA
WP_158190561.1\|819581_819881_+	hypothetical protein	NA	NA	NA	NA
WP_158190562.1\|819880_821707_+\|plate	BppU family phage baseplate upper protein	O03968	Lactobacillus_phage	5.4e-119	40.5
WP_158190563.1\|821718_822459_+	hypothetical protein	NA	NA	NA	NA
WP_158190564.1\|822458_822800_+	DUF2977 domain-containing protein	NA	NA	NA	NA
WP_158190565.1\|822796_822949_+	XkdX family protein	NA	NA	NA	NA
WP_158190566.1\|822987_823389_+\|holin	holin	A0A097BY69	Enterococcus_phage	5.7e-21	41.0
WP_158190567.1\|823372_824707_+	1,4-beta-N-acetylmuramidase	A0A1X9IGI4	Lactococcus_phage	4.7e-80	66.5
WP_158190568.1\|824836_824995_+	hypothetical protein	NA	NA	NA	NA
WP_002833537.1\|825397_825910_+	hypothetical protein	NA	NA	NA	NA
825109:825133	attR	NA	NA	NA	NA
WP_011673281.1\|826243_826873_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_002833539.1\|827002_827311_+	50S ribosomal protein L21	NA	NA	NA	NA
WP_011673282.1\|827332_827659_+\|protease	ribosomal-processing cysteine protease Prp	NA	NA	NA	NA
WP_002833541.1\|827682_827970_+	50S ribosomal protein L27	NA	NA	NA	NA
WP_002833542.1\|828094_828658_+	elongation factor P	NA	NA	NA	NA
WP_002833543.1\|828675_829104_+	Asp23/Gls24 family envelope stress response protein	NA	NA	NA	NA
WP_002833544.1\|829103_829505_+	transcription antitermination factor NusB	NA	NA	NA	NA
WP_158190569.1\|829630_830482_+	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD	A0A249XZQ2	Enterococcus_phage	6.4e-38	39.7
WP_158190570.1\|830482_831826_+	exodeoxyribonuclease VII large subunit	A0A2H4UVM9	Bodo_saltans_virus	4.6e-43	30.6
WP_002833547.1\|831825_832062_+	exodeoxyribonuclease VII small subunit	NA	NA	NA	NA
WP_158190571.1\|832054_832945_+	polyprenyl synthetase family protein	NA	NA	NA	NA
WP_002833549.1\|832958_833777_+	TlyA family RNA methyltransferase	NA	NA	NA	NA
WP_002833550.1\|833785_834244_+	arginine repressor, DNA-binding domain protein	NA	NA	NA	NA
WP_158190572.1\|834255_835932_+	DNA repair protein RecN	NA	NA	NA	NA
WP_011673284.1\|836003_836339_-	hypothetical protein	NA	NA	NA	NA
WP_002833553.1\|836634_837249_+	guanylate kinase	A0A223FN12	Murmansk_poxvirus	1.8e-18	32.9
WP_002833554.1\|837250_837460_+	DNA-directed RNA polymerase subunit omega	NA	NA	NA	NA
WP_158190573.1\|837571_838765_+	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC	Q9HH70	Methanothermobacter_phage	4.7e-39	30.6
WP_158190574.1\|838779_841200_+	primosomal protein N'	NA	NA	NA	NA
WP_158190575.1\|841222_842185_+\|tRNA	methionyl-tRNA formyltransferase	E3SNR5	Prochlorococcus_phage	5.7e-11	39.3

DBSCAN-SWA_4

862617 : 904410

Lactobacillus_phage(46.43%)

tail,capsid,integrase,head,terminase,tRNA,portal

attL 854734:854750|attR 902686:902702

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
854734:854750	attL	NA	NA	NA	NA
WP_158190585.1\|862617_863355_+\|tRNA	tRNA (guanosine(37)-N1)-methyltransferase TrmD	NA	NA	NA	NA
WP_158190586.1\|863497_863857_+	50S ribosomal protein L19	NA	NA	NA	NA
WP_002833580.1\|864278_864602_-	heavy metal-binding domain-containing protein	M4STD1	Rhodobacter_phage	3.5e-05	34.6
WP_011673301.1\|864642_864975_-	hypothetical protein	NA	NA	NA	NA
WP_011673302.1\|865388_865838_+	3-hydroxyacyl-ACP dehydratase FabZ	NA	NA	NA	NA
WP_158190587.1\|865851_866811_+	beta-ketoacyl-ACP synthase III	NA	NA	NA	NA
WP_002833584.1\|866849_867089_+	acyl carrier protein	NA	NA	NA	NA
WP_158190979.1\|867106_868039_+	acyltransferase domain-containing protein	NA	NA	NA	NA
WP_158190588.1\|868039_868768_+	SDR family oxidoreductase	W8CYX9	Bacillus_phage	1.4e-06	40.3
WP_002833587.1\|868786_870013_+	beta-ketoacyl-ACP synthase II	NA	NA	NA	NA
WP_002833588.1\|870018_870456_+	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit	NA	NA	NA	NA
WP_002833589.1\|870455_870869_+	beta-hydroxyacyl-ACP dehydratase	NA	NA	NA	NA
WP_158190589.1\|870886_872254_+	acetyl-CoA carboxylase biotin carboxylase subunit	NA	NA	NA	NA
WP_002833591.1\|872243_873074_+	acetyl-CoA carboxylase carboxyltransferase subunit beta	NA	NA	NA	NA
WP_138428718.1\|873087_873855_+	acetyl-CoA carboxylase carboxyl transferase subunit alpha	NA	NA	NA	NA
WP_002833593.1\|873871_874630_+	enoyl-ACP reductase FabI	NA	NA	NA	NA
WP_158190590.1\|874768_875941_-\|integrase	tyrosine-type recombinase/integrase	A0A1B0T6A8	Bacillus_phage	7.7e-18	26.4
WP_158190591.1\|876036_876939_-	DNA adenine methylase	A0A1D8KT41	Synechococcus_phage	2.8e-07	22.4
WP_158190592.1\|876982_878725_-	hypothetical protein	NA	NA	NA	NA
WP_158190593.1\|878812_879751_-	DUF3862 domain-containing protein	NA	NA	NA	NA
WP_158190594.1\|879827_880220_-	ImmA/IrrE family metallo-endopeptidase	A0A0A7RTX7	Clostridium_phage	2.8e-09	38.0
WP_099299649.1\|880226_880562_-	helix-turn-helix transcriptional regulator	E9LUL4	Lactobacillus_phage	2.3e-12	51.9
WP_158190595.1\|880710_880932_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_158190596.1\|880963_881206_+	hypothetical protein	NA	NA	NA	NA
WP_069825579.1\|881414_881738_+	hypothetical protein	NA	NA	NA	NA
WP_158190597.1\|881738_882014_+	hypothetical protein	NA	NA	NA	NA
WP_158190598.1\|882251_882533_+	hypothetical protein	NA	NA	NA	NA
WP_158190599.1\|882525_883290_+	phage recombination protein Bet	A8ATK8	Listeria_phage	3.6e-56	51.1
WP_158190980.1\|883324_884095_+	hypothetical protein	A0A0P0IZH9	Lactobacillus_phage	1.6e-56	45.3
WP_158190600.1\|884105_884981_+	helix-turn-helix domain-containing protein	A0A0P0I7Q1	Lactobacillus_phage	4.1e-40	39.4
WP_158190601.1\|884984_885686_+	hypothetical protein	E9LUU3	Lactobacillus_phage	5.3e-83	65.5
WP_158190602.1\|885654_885915_+	hypothetical protein	NA	NA	NA	NA
WP_158190603.1\|885933_886449_+	single-stranded DNA-binding protein	A0A191KBY9	Streptococcus_virus	5.9e-39	67.5
WP_158190604.1\|886599_886917_+	hypothetical protein	NA	NA	NA	NA
WP_158190605.1\|887079_887277_+	hypothetical protein	A0A0A7S0P6	Clostridium_phage	2.8e-05	44.7
WP_158190606.1\|887474_887717_+	hypothetical protein	NA	NA	NA	NA
WP_158190607.1\|888097_888541_+	hypothetical protein	NA	NA	NA	NA
WP_158190608.1\|888844_889465_+	hypothetical protein	NA	NA	NA	NA
WP_158190609.1\|889784_890261_+	hypothetical protein	NA	NA	NA	NA
WP_158190610.1\|890303_890840_+\|terminase	terminase small subunit	O03926	Lactobacillus_phage	1.6e-47	69.0
WP_158190611.1\|890823_892095_+\|terminase	PBSX family phage terminase large subunit	Q6SE84	Lactobacillus_prophage	1.2e-170	67.5
WP_158190981.1\|892175_893495_+\|portal	phage portal protein	A0A0A1ER87	Lactobacillus_phage	5.2e-140	56.9
WP_158190612.1\|893478_894444_+\|head	phage head morphogenesis protein	A0A0P0ID43	Lactobacillus_phage	6.2e-74	47.6
WP_158190613.1\|894446_894815_+	hypothetical protein	NA	NA	NA	NA
WP_158190614.1\|894873_895119_+	hypothetical protein	F0PII8	Enterococcus_phage	4.2e-19	81.4
WP_158190615.1\|895221_895917_+	DUF4355 domain-containing protein	A0A0A1EN85	Lactobacillus_phage	4.3e-16	37.1
WP_158190616.1\|895916_896735_+\|capsid	N4-gp56 family major capsid protein	B5SP31	Lactococcus_phage	4.3e-100	72.0
WP_158190982.1\|896752_897019_+	hypothetical protein	NA	NA	NA	NA
WP_158190617.1\|897030_897402_+	hypothetical protein	A0A0P0IV23	Lactobacillus_phage	6.0e-25	52.0
WP_158190618.1\|897406_897709_+	hypothetical protein	A0A097BYD2	Leuconostoc_phage	1.4e-16	48.0
WP_158190619.1\|897701_898073_+	hypothetical protein	A0A0P0I3G7	Lactobacillus_phage	5.8e-12	39.5
WP_158190620.1\|898073_898481_+	hypothetical protein	A0A0A1EN91	Lactobacillus_phage	3.5e-18	35.7
WP_141822621.1\|898498_899095_+\|tail	phage major tail protein, TP901-1 family	A0A0A1ELH3	Lactobacillus_phage	5.1e-50	54.0
WP_158190621.1\|899172_899451_+	hypothetical protein	NA	NA	NA	NA
WP_158190622.1\|899530_899869_+	hypothetical protein	A0A097BY80	Leuconostoc_phage	1.2e-27	57.5
WP_141822627.1\|899916_900303_+	hypothetical protein	A0A1B0Y2Q4	Lactobacillus_phage	2.9e-22	52.1
WP_158190623.1\|900295_903646_+\|tail	phage tail tape measure protein	A0A097BYC3	Leuconostoc_phage	3.8e-134	61.0
902686:902702	attR	NA	NA	NA	NA
WP_158190624.1\|903645_904410_+\|tail	phage tail protein	Q6SEC3	Lactobacillus_prophage	1.0e-55	46.4

DBSCAN-SWA_5

943239 : 949522

Megavirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011673326.1\|943239_945099_+	molecular chaperone DnaK	A0A2P1EIW2	Megavirus	5.3e-138	47.2
WP_002833625.1\|945195_946320_+	molecular chaperone DnaJ	A0A0P0YNN4	Yellowstone_lake_phycodnavirus	1.3e-22	33.2
WP_158190644.1\|946424_946652_-	DUF378 domain-containing protein	NA	NA	NA	NA
WP_158190645.1\|946780_947251_-	tryptophan-rich sensory protein	NA	NA	NA	NA
WP_069825315.1\|947487_947970_+	QueT transporter family protein	E7DN70	Pneumococcus_phage	1.7e-11	35.7
WP_158190646.1\|947986_948208_+	DUF2829 domain-containing protein	G3MBC9	Bacillus_virus	5.1e-08	33.7
WP_158190647.1\|948208_948949_+	3-oxoacyl-ACP reductase	Q06VL0	Trichoplusia_ni_ascovirus	3.7e-18	30.9
WP_158190648.1\|949072_949522_+	DUF4373 domain-containing protein	A0A0P0HRQ2	Lactobacillus_phage	5.9e-43	57.9

DBSCAN-SWA_6

1061193 : 1070811

Staphylococcus_phage(37.5%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_158190701.1\|1061193_1062039_-	DegV family EDD domain-containing protein	A0A0N9SI50	Staphylococcus_phage	1.4e-16	35.2
WP_023440467.1\|1062275_1063013_-	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.3e-34	40.4
WP_158190702.1\|1063009_1064461_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_158190985.1\|1064582_1065059_-	dihydrofolate reductase	A0A0N9S8H6	Staphylococcus_phage	2.0e-25	40.1
WP_011673474.1\|1065096_1066047_-	thymidylate synthase	A0A0N9SH48	Staphylococcus_phage	3.4e-117	62.7
WP_158190703.1\|1066059_1067937_-	ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	2.9e-51	30.5
WP_158190704.1\|1067939_1069148_-\|tRNA	CCA tRNA nucleotidyltransferase	G3MAR3	Bacillus_virus	3.5e-34	40.0
WP_158190705.1\|1069401_1070286_+	DUF2179 domain-containing protein	M1Q1P6	Streptococcus_phage	2.1e-52	38.1
WP_002833201.1\|1070340_1070811_-	nucleoside deoxyribosyltransferase	A0A1G5S9Z4	Enterococcus_phage	3.8e-16	40.1

DBSCAN-SWA_7

1442526 : 1451090

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_099299707.1\|1442526_1443108_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	3.9e-23	35.2
WP_158190834.1\|1443104_1444154_-	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D8KLC2	Synechococcus_phage	1.8e-58	40.5
WP_158190835.1\|1444153_1445623_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	8.1e-57	32.5
WP_158190836.1\|1445607_1447815_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	9.7e-147	41.6
WP_158190837.1\|1447832_1448507_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_158190838.1\|1448509_1448764_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_002833286.1\|1448756_1449485_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D7SLB8	Cyanophage	1.6e-42	43.4
WP_158190839.1\|1449484_1450624_-	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_011673684.1\|1450607_1451090_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	2.6e-20	42.9

DBSCAN-SWA_8

1460449 : 1469316

Streptococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023440679.1\|1460449_1461466_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	5.6e-33	30.6
WP_002833272.1\|1461465_1461801_-	hypothetical protein	NA	NA	NA	NA
WP_158190844.1\|1461816_1462446_-	dTMP kinase	M1PSC7	Streptococcus_phage	2.6e-52	52.7
WP_002833270.1\|1462610_1463210_-	recombination protein RecR	NA	NA	NA	NA
WP_002833269.1\|1463236_1463551_-	YbaB/EbfC family nucleoid-associated protein	NA	NA	NA	NA
WP_158190845.1\|1463566_1465312_-	DNA polymerase III subunit gamma/tau	A0A1U9WR94	Streptococcus_virus	2.8e-56	48.4
WP_060743850.1\|1465523_1466009_-	nucleoside deaminase	A0A2H4PQS8	Staphylococcus_phage	1.8e-05	31.6
WP_158190846.1\|1466001_1466607_-	methyltransferase	NA	NA	NA	NA
WP_011673696.1\|1466818_1467049_+	glutaredoxin-like protein NrdH	A0A0M7REK7	Lactobacillus_phage	8.0e-12	48.1
WP_158190847.1\|1467150_1469316_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A8E2R1	Enterococcus_phage	8.9e-254	60.6

DBSCAN-SWA_9

1687100 : 1697957

Bacillus_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_158190920.1\|1687100_1688276_+	methyltransferase domain-containing protein	A0A2K9L4K8	Tupanvirus	3.7e-44	33.3
WP_002834110.1\|1688426_1688759_-	AzlD domain-containing protein	NA	NA	NA	NA
WP_002834111.1\|1688779_1689568_-	branched-chain amino acid ABC transporter	NA	NA	NA	NA
WP_158190921.1\|1689699_1690956_-	serine hydrolase	B6DZZ7	Stx2-converting_phage	7.7e-08	23.8
WP_011673829.1\|1691136_1692273_-	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	2.8e-25	25.8
WP_002834114.1\|1692284_1692974_-	response regulator transcription factor	W8CYM9	Bacillus_phage	5.7e-37	37.3
WP_158190922.1\|1693056_1693554_-	methylated-DNA--[protein]-cysteine S-methyltransferase	G5CRV0	Megavirus	8.3e-14	35.6
WP_011673831.1\|1693685_1694828_-	guanosine monophosphate reductase	A0A1V0SHK8	Klosneuvirus	2.4e-64	34.0
WP_158190923.1\|1694849_1695554_-	DUF1129 family protein	NA	NA	NA	NA
WP_002834120.1\|1695582_1696689_-	redox-regulated ATPase YchF	NA	NA	NA	NA
WP_002834122.1\|1696906_1697092_-	DUF951 domain-containing protein	NA	NA	NA	NA
WP_158190924.1\|1697105_1697957_-	ParB/RepB/Spo0J family partition protein	S5VTK0	Leptospira_phage	1.6e-12	35.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP046938

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection