CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number
NZ_CP044551	Hydrogenophaga sp. BPS33 plasmid pBPS33-2, complete sequence	0 crisprs	NA	0	0	1
NZ_CP044550	Hydrogenophaga sp. BPS33 plasmid pBPS33-1, complete sequence	2 crisprs	csa3	0	2	2
NZ_CP044549	Hydrogenophaga sp. BPS33 chromosome, complete genome	7 crisprs	Cas9_archaeal,DEDDh,csa3,WYL,DinG,PD-DExK,RT	6	1	5

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

13997 : 81894

Salmonella_phage(44.44%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003158660.1\|13997_16913_+\|transposase	Tn3-like element IS1071 family transposase	A0A1B0V7H9	Salmonella_phage	1.4e-52	24.0
WP_053281476.1\|17970_19035_+	4-hydroxy-2-oxovalerate aldolase	E5EQ69	Micromonas_sp._RCC1109_virus	3.0e-37	29.5
WP_053281475.1\|19894_20809_+	hypothetical protein	NA	NA	NA	NA
WP_053281474.1\|20985_21192_-	hypothetical protein	NA	NA	NA	NA
WP_159597433.1\|21629_23168_+\|transposase	IS91-like element ISPps1 family transposase	NA	NA	NA	NA
WP_159597434.1\|23838_24879_+	EamA family transporter	NA	NA	NA	NA
WP_159597435.1\|24995_26414_-	efflux transporter outer membrane subunit	NA	NA	NA	NA
WP_159597436.1\|32197_32602_+\|transposase	transposase	A0A218MNE7	uncultured_virus	3.1e-27	43.2
WP_068673276.1\|32619_33126_+	hypothetical protein	NA	NA	NA	NA
WP_083944095.1\|33171_33480_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_068673274.1\|33931_34630_-	dienelactone hydrolase family protein	NA	NA	NA	NA
WP_068673272.1\|34622_35801_-	muconate cycloisomerase family protein	NA	NA	NA	NA
WP_068673271.1\|35802_36882_-	maleylacetate reductase	NA	NA	NA	NA
WP_068673269.1\|36891_37227_-	hypothetical protein	NA	NA	NA	NA
WP_083944094.1\|37240_37789_-	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_159597437.1\|37847_38795_-	tripartite tricarboxylate transporter substrate binding protein	NA	NA	NA	NA
WP_068673263.1\|39178_39925_-	hypothetical protein	NA	NA	NA	NA
WP_159597438.1\|40427_41075_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_003158660.1\|41193_44109_+\|transposase	Tn3-like element IS1071 family transposase	A0A1B0V7H9	Salmonella_phage	1.4e-52	24.0
WP_032490114.1\|44394_45408_-	ferredoxin--NADP reductase	NA	NA	NA	NA
WP_083944717.1\|45419_46064_-	aromatic-ring-hydroxylating dioxygenase subunit beta	NA	NA	NA	NA
WP_159597439.1\|46060_47410_-	Rieske 2Fe-2S domain-containing protein	NA	NA	NA	NA
WP_159597440.1\|47446_48208_-	hypothetical protein	NA	NA	NA	NA
WP_159597441.1\|48326_49805_-	glutamine synthetase	NA	NA	NA	NA
WP_068685872.1\|50082_52431_+	indolepyruvate ferredoxin oxidoreductase subunit alpha	NA	NA	NA	NA
WP_011114060.1\|57067_58117_-	ParB/RepB/Spo0J family partition protein	S5VTK0	Leptospira_phage	3.2e-07	31.2
WP_011114061.1\|58113_58878_-	ParA family protein	NA	NA	NA	NA
WP_011114062.1\|58874_59183_-	KorA protein	NA	NA	NA	NA
WP_011114064.1\|59289_59619_-	DUF2761 domain-containing protein	NA	NA	NA	NA
WP_011114065.1\|59620_59947_-	hypothetical protein	NA	NA	NA	NA
WP_011114066.1\|60155_60392_-	hypothetical protein	NA	NA	NA	NA
WP_011114067.1\|60549_60807_-	hypothetical protein	NA	NA	NA	NA
WP_011114068.1\|60823_62032_-	hypothetical protein	NA	NA	NA	NA
WP_011296181.1\|62043_62307_-	hypothetical protein	NA	NA	NA	NA
WP_011114069.1\|62306_62735_-	antirestriction protein	A0A1S5R3R9	Pseudomonas_phage	6.3e-10	38.8
WP_011114070.1\|62907_63171_+	type II toxin-antitoxin system RelB/DinJ family antitoxin	NA	NA	NA	NA
WP_011114071.1\|63157_63439_+	type II toxin-antitoxin system YafQ family toxin	NA	NA	NA	NA
WP_003049965.1\|64155_67071_+\|transposase	Tn3-like element IS1071 family transposase	A0A1B0V7H9	Salmonella_phage	1.4e-52	24.0
WP_068683781.1\|67316_67943_-	lytic transglycosylase domain-containing protein	I1VXB7	Halocynthia_phage	5.9e-09	43.4
WP_083944708.1\|67930_68569_-	S26 family signal peptidase	NA	NA	NA	NA
WP_083944709.1\|68498_68729_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_068683784.1\|68915_69194_-	hypothetical protein	NA	NA	NA	NA
WP_068683789.1\|69268_69502_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_068683790.1\|69510_70020_-	DUF2285 domain-containing protein	NA	NA	NA	NA
WP_068683792.1\|70266_71133_-	phytanoyl-CoA dioxygenase	NA	NA	NA	NA
WP_068683794.1\|71129_71735_-	autoinducer synthase	NA	NA	NA	NA
WP_083944710.1\|71808_72594_-	LuxR family transcriptional regulator	NA	NA	NA	NA
WP_159597442.1\|72750_74460_-	amidohydrolase family protein	NA	NA	NA	NA
WP_159597443.1\|74491_75316_-	hypothetical protein	NA	NA	NA	NA
WP_068685872.1\|75593_77942_+	indolepyruvate ferredoxin oxidoreductase subunit alpha	NA	NA	NA	NA
WP_003158660.1\|78978_81894_+\|transposase	Tn3-like element IS1071 family transposase	A0A1B0V7H9	Salmonella_phage	1.4e-52	24.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP044550

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP044550_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044550_1

8354-8437

Orphan

Consensus_repeat	Method
CATCATACGCTGTACAGCGTATAAACCCA	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP044550_1

>merge|NZ_CP044550|1|8354-8437|CRISPRCasFinder
CATCATACGCTGTACAGCGTATAAACCCATTTTGAGATATCATATTCTCAAATGCCATCATACGCTGTACAGCGTATAAACCCA

>NZ_CP044550|1|1|8354-8437|CRISPRCasFinder
CATCATACGCTGTACAGCGTATAAACCCA	TTTTGAGATATCATATTCTCAAATGC
CATCATACGCTGTACAGCGTATAAACCCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044550.1\|WP_159597178.1\|16109_16418_-\|metalloregulator-ArsR/SmtB-family-transcription-factor	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP044550.1\|WP_159597170.1\|5913_6861_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044550.1\|WP_159597168.1\|2527_4417_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271175
NZ_CP044550.1\|WP_159597180.1\|18556_19864_-\|response-regulator	unknown	unknown	gnl\|CDD\|225114
NZ_CP044550.1\|WP_159597171.1\|6884_7541_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044550.1\|WP_159597410.1\|7663_7876_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044550.1\|WP_159597173.1\|8445_9540_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044550.1\|WP_159597166.1\|0_1209_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|274585
NZ_CP044550.1\|WP_159597174.1\|9856_10627_+\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NZ_CP044550.1\|WP_159597169.1\|4413_5103_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044550.1\|WP_159597177.1\|14581_16048_-\|NAD(P)-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|379355
NZ_CP044550.1\|WP_159597175.1\|10517_11894_+\|IS30-family-transposase	unknown	unknown	gnl\|CDD\|225382
NZ_CP044550.1\|WP_159597181.1\|19860_21306_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP044550.1\|WP_159597167.1\|1213_2236_+\|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl\|CDD\|319262
NZ_CP044550.1\|WP_159597179.1\|16560_18525_+\|NACHT-domain-containing-protein	unknown	unknown	gnl\|CDD\|227922
NZ_CP044550.1\|WP_159597176.1\|13395_14580_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340913
NZ_CP044550.1\|WP_066273726.1\|9563_9860_+\|transposase	unknown	unknown	gnl\|CDD\|366690
NZ_CP044550.1\|WP_159597172.1\|7973_8285_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP044550.1\|WP_159597178.1\|16109_16418_-\|metalloregulator-ArsR/SmtB-family-transcription-factor	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	6.21408e-12
NZ_CP044550.1\|WP_159597168.1\|2527_4417_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271175	cd00397, DNA_BRE_C, DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	7.27501e-22
NZ_CP044550.1\|WP_159597180.1\|18556_19864_-\|response-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	8.74962e-148
NZ_CP044550.1\|WP_159597166.1\|0_1209_+\|AAA-family-ATPase	gnl\|CDD\|274585	TIGR03453, partition_RepA, plasmid partitioning protein RepA. Members of this family are the RepA (or ParA) protein involved in replicon partitioning. All known examples occur in bacterial species with two or more replicons, on a plasmid or the smaller chromosome. Note that an apparent exception may be seen as a pseudomolecule from assembly of an incompletely sequenced genome. Members of this family belong to a larger family that also includes the enzyme cobyrinic acid a,c-diamide synthase, but assignment of that name to members of this family would be in error. [Mobile and extrachromosomal element functions, Plasmid functions].	6.1885e-65
NZ_CP044550.1\|WP_159597174.1\|9856_10627_+\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	2.7798e-44
NZ_CP044550.1\|WP_159597177.1\|14581_16048_-\|NAD(P)-binding-domain-containing-protein	gnl\|CDD\|379355	pfam13738, Pyr_redox_3, Pyridine nucleotide-disulphide oxidoreductase.	8.76481e-17
NZ_CP044550.1\|WP_159597175.1\|10517_11894_+\|IS30-family-transposase	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	6.96537e-90
NZ_CP044550.1\|WP_159597181.1\|19860_21306_-\|sensor-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.48692e-26
NZ_CP044550.1\|WP_159597167.1\|1213_2236_+\|ParB/RepB/Spo0J-family-partition-protein	gnl\|CDD\|319262	cd16405, RepB_like_N, plasmid segregation replication protein B like protein, N-terminal domain. RepB, found on plasmids and secondary chromosomes, works along with repA in directing plasmid segregation, and has been shown in Rhizobium etli to require the parS centromere-like sequence for full transcriptional repression of the repABC operon, inducing plasmid incompatibility. RepA is a Walker-type ATPase that complexes with RepB to form DNA-protein complexes in the presence of ATP/ADP. RepC is an initiator protein for the plasmid. repA and repB are homologous to the parA and ParB genes of the parABS partitioning system found on primary chromosomes.	3.58967e-31
NZ_CP044550.1\|WP_159597179.1\|16560_18525_+\|NACHT-domain-containing-protein	gnl\|CDD\|227922	COG5635, COG5635, Predicted NTPase (NACHT family) [Signal transduction mechanisms].	5.89391e-55
NZ_CP044550.1\|WP_159597176.1\|13395_14580_-\|MFS-transporter	gnl\|CDD\|340913	cd17355, MFS_YcxA_like, MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters. This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.84648e-30
NZ_CP044550.1\|WP_066273726.1\|9563_9860_+\|transposase	gnl\|CDD\|366690	pfam01527, HTH_Tnp_1, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.	3.32042e-12

>NZ_CP044550.1|WP_159597172.1|7973_8285_+|hypothetical-protein
MESDLTPSPLRVIDRDLLRKEFAAIEARQAVLTDQGQKLMARIRPSSKYHGQGKEGALFAVCIGPIGDYCVFGGPGGQYRLSDVDLFAVFDETRPPTQITFEP
>NZ_CP044550.1|WP_159597410.1|7663_7876_+|hypothetical-protein
MPKGSQLTNRDHDNMDAFLSHVLDDYKAGHLSKKDLTLGLAQVISALDCGNVDEARNWFENGRKLIRQGG
>NZ_CP044550.1|WP_159597171.1|6884_7541_+|hypothetical-protein
MEIPTRFGPLPGFALPADARLYRIYRHVDADWSVAPEPHRKGRVDPPLPDSSAYGLLYLADSLVTAGFEARILRPTKDADGLNDISIEPEPMDLVTGRALKPPPMTAVHTTKQPIVFVDLESPDIARAAAIAIGRPVPRIDKWRKLTLWVHDQLIVPGDGNSILPLVGATYLSNVPDCVGRNFVVFEGRRDAHIHRGVPPESQTPLDVPGLQALWENA
>NZ_CP044550.1|WP_159597170.1|5913_6861_+|hypothetical-protein
MEYQQILISLPNHEADRAAAAAHLEAHQKRIARETAEAVSDVFESALKESRAHTFVMVSSQTLATLGVLDKIGRHLVGASLPKLSSEYESAVALLAQQHDPLLQRDLYEALFQGNVFYGGSRHDPLSQRPLALEVEDLAFADDDKPRDENQARFVHLATFKRLHALLGELVQQDKTSPDVIAPADDPNELLDAKTFAQRMGATDQTVYNREKAGLLISVLPPKRVRKRGFPSFQLSPRLNQELHQLAIAMYRSHGQDMTFYWHFLRTRHQDLGGSTGVEFLLNRISDPSLLDLEQSERQAIFLALAEEDMLRASA
>NZ_CP044550.1|WP_159597169.1|4413_5103_-|hypothetical-protein
MATSTYPGLPADFKSRHKPSADLVERHATTAKYHGGASFKSKASAAKRSATTLRKTADELKDTVSAADLQALQRAAQVLDRQAEDLAVFARWADQYKDFSDQRRLEDDTASARALAQARWGDDPAAHQLDRQLMDECDSLIGGEKLGLFVLKNYPRFAGVKPENFMLSGYRSTRLDGADERTNTAHCIISIDARSSRYERASGESMAMIGRDIFDAYVAHRRAEKANLK
>NZ_CP044550.1|WP_159597168.1|2527_4417_-|tyrosine-type-recombinase/integrase
MSRARIGPHHLAYLRAVADGLEVLACARTYLGIEDPREAQIAHNELSAQLRLAAKQAGERHHRLIGIRIREKTRQAPTQAKRPTLSEFIEARNLDGWSEAEQLELYEAEYPPAPQASTAYATLQRRERSRQRVVEILRRLEVDGRTTAQPRPTDEVDAWFADHLAQRLVRAGYVNLQQLADRVRQGGQWYSGITAVGRTKAVHIAQQLEAILPGSTRRRSMGFAAPTQALIGLPESRTKALVDRPENRAQIRPGNQPESPSGNGLLPPSSDLNTAWRADNIGAIGTDPQALATWAEACAGSQATRKSYLREGRRLLLWMQIERAGRRLLDFKLDDAQAYRTFLAYVPDGWISRAKASPAQEGWTPFKGQLSAASQRQAMTILASWFDWLCNAEYLRANPWKLVKKTGQSMASTQDSRALDTKAISLKAMGEIGAFIERQAPSPARARARFVVAFLSTTGLRSAELLAAKISDIRVEPEGVFLRVVGKGKKARDVMLVDVALNVLDDYLASRGLESLDVAPGNAPVLASLADPMKPVSYQTLYKTTRAWLSRAVTTSALSAAEQSRLQGASTHWLRHTFGTTSVALGTPYDVVQQQLGHSRIDTTMSIYSRAPLQRRAAELQRAWAKVTE
>NZ_CP044550.1|WP_159597167.1|1213_2236_+|ParB/RepB/Spo0J-family-partition-protein
MSQKKPNLRDRALAAIGPAGSAPAPAPVAAPTPRTGPGALMVHLARESDAQRENDRLRDELNQWEGAKATRLLDPKLVGWSTWANRDQANFTGADFLELKQEIASAGGNVQPIKVRVNKPGGEYEFEIVFGHRRHRACLELGLPVLAVIDNLGEVDLFVQMDRENRSRKNLSAWEQGMMYQRALEKGLFPSSRKLAEQVGVDLGQVGKAISLAKLPREVVDAFASPLDLQFRWAKPLADSLERDLSGLVARANMAKALGANRSAKDVLEMLLAAEGEGGRTVQPPPIVIQRNGKEAASITFDGKGRATVSFAATVVGPDQLKALSELVDAFIANTTKATK
>NZ_CP044550.1|WP_159597166.1|0_1209_+|AAA-family-ATPase
MNKTHSLIPEIGISELDAVSANALHVVSQVRTAMLAPEARKSAPTYNSTQLAELCGVDKNRLQYLVRKGDLSGGTKDDSGRREWTLAEARECIKSFRVESLRDAAKAPGAVITVANFKGGVSKTTTAAALAQGLSLRGHKVLVIDCDPQGSLTTLFGVLPDTEVEETDTILPLCAGDADSVMPAIQKTYWDGIDLVAAAPLLFNAEFLLPSRQKSERGFAFWRVLDDGLTAARDAYDIIIIDTPPSLSYITINALIAADGVVMPLPPNALDFASSAQFWNLFTEVCGGLFKAGGDDKKFSFVDVVLSRVDRADAVSVAVRQWIGSAYGRHVIPVEIPKTSVAASASAEFGTVYDLGPSSVQAKTLKRARDAYESLVDYVEQQVAGVWAHSADVVSAVIKKEG
>NZ_CP044550.1|WP_159597173.1|8445_9540_+|hypothetical-protein
MHPERRLADKLLTEFTAVLRDRLNIDGIEAEHEPSFGTGAADLVLSIPVDGVRVKVVVEVKKNAFPRDIEWARVQLEGLEREDSTIDQKMVWAESLSEGARKSLEALDIGYFDSSGSISLKLGRHHILIDRPPIKPLWREVGTVFTPERARVLHSLLLGWDKWRTGVELAKDSRASPNTVSVLLRELEKRGMVQSEGSGRNVRRQLVQPDALLDAWANHWAEGKRRKTRWFAFAQNPGNLALRLVSRLLQDHDEWALTGQYAANCVTPLLTAVNGFDIIVPVGMAEAFAEDLELKRADKGFNVTLHECEDFALQHRLQLPDRHGFFASPVIQYLELANEGGRSKELANELKNHLGFPQFPGHIQ
>NZ_CP044550.1|WP_066273726.1|9563_9860_+|transposase
MTRTRRSFTDEFKREAVKLCKQPGATVTHIARDLGIQTSVLRRWVTQERGGVLDLRPNRPLRSEAATEVERLQRELRRVTTERDILKKALGYFAKDPQ
>NZ_CP044550.1|WP_159597174.1|9856_10627_+|IS3-family-transposase
MKYGFIARHRSVWPTRTMCRVLAVSHSGFYEWMDRAPSQRSQDDARLTRLIRESFELSDRTYGSPRVWHDLRALGESCGMNRVIRLMHLAKLQARHKRRRLPGDTGSRLENHIAPNHLQRDFQASGPNQKWVADFTYIWTAEGWLYAAAVMDLYSRRIVGWSMSDTMQAKMVSDALLMALWRRGKPSALMHHSDQGSQGGFNRSSQHLQSWRCYGKTSGLDARVNGAIGDAITWRAIASARSGAAVLAADRERNHE
>NZ_CP044550.1|WP_159597175.1|10517_11894_+|IS30-family-transposase
MQELTGRSAMRSPGAPSHRREVERQFWQQIASGITSERAAEAVGVSQPVGTRWFRHRGGMPLFLSKSVSVRYLSFAEREEIALLRAQDVGVREIARRLGRSPSTVSRELTRNAATRGGKLEYRASVAQWKSELVARRPKPAKLVVNPLLRQYVQDRLEGNILDAQGREVAGPVQAAFLGRNKPHRSDRKWVNGWSPEQIANRLQVDFQDDSSMRISHEAIYQALYIQGRGALKRELVGYLRTGRALRVPRARAQAKAWAHVSEEVMISSRPAEAKDRAVPGHWEGDLIIGLDRSAIGTLVERSSRFTMLVHLPREAGYGLTPRTKNGPALAGYGAITMANALKRIVTTLPAQLWQSLTWDRGKELSDHARFTIESGVKVFFADPHSPWQRGTNENTNGLLRQYFPKGTDLSRWSEQEIQAVARTLNNRPRKTLGWKTPAETLNEYLKSVRQPGVATTG
>NZ_CP044550.1|WP_159597176.1|13395_14580_-|MFS-transporter
MASASNVGTVAALGTAQTLAWASTYYLPAMLAVPMARDLGVNTPTVFAAFSVALGVSALVGPWAGRAIDLHGGRPVLMGTSLFFAIGLVALGASQGVWSLFAAWMLIGLAMGSGLYEAAFSALVRLYGHGSRSAITGITLIAGFASTVGWPLSTLLEAQFGWRGACFAWAGLHLVFGLPLNAALPRVAVVAPSDSKKPLDIDAVPQSAVRARVTTALLAFVFATTWFISTAMAAHLPSLLQASGASLAVAVGVGALIGPAQVAGRLLEFGFLRHVHPLLSARLASLGHPVGVVALLIAGPVLAPLFAVLHGAGNGILTIAKGTLPLVLFGPQGYGLRQGWLMLPARVAQALAPFLFGLALVRWGAGALLLSAGLGIMALLALLALPGETPRSNR
>NZ_CP044550.1|WP_159597177.1|14581_16048_-|NAD(P)-binding-domain-containing-protein
MKEQSTSSSPVAVIGAGPVGLAAAAHLVGRGLPVVVLEAGTSVATHLGSYRHVRLFSPWRYNVDRAARALLETTGWSAPNDDDLPTAGEVVDDYLAPLARTPALAPHIQFGARVTAVSRDGFDKAKTAGREHADFLLQVQSDKGLREVRARAVIDASGTWSQPNPLGVHGLPVLGEIEARAHIAHGMPDVLDTDRHRYVGRKVLVVGAGHSAAGNLLALARLAEQEPDTRVVWAVRGTDLRKLFGGGENDGLPARGQLGTSLRAMIEEGRLELHLGFGIREIVAQPDGMRLFAADVDKTPIEGIDEIIVSTGARPDLNITRELRLRLDPWLESTDALAPLIDPNVHSCGTVRPHGHRELMHPEPGFYAIGAKSYGRAPSFLMATGYEQARSVVAALAGDLRAADDVQLELPETGVCSVNLASPDLTAGNASCCGGPAKFDTVACCSLDQMSRAQSQSGCGCGPKRATSATTPPEAERPRAAPSKACCS
>NZ_CP044550.1|WP_159597178.1|16109_16418_-|metalloregulator-ArsR/SmtB-family-transcription-factor
MAKTHCAPLPVDEELDAEELAVLLKALAHPARIRLLQHLAHHGTCYFGNLSDVVELAPSTTSQHVKVLKDAGLVLGSAEEQRTCYCVNPDRLAVLKRLVEAL
>NZ_CP044550.1|WP_159597179.1|16560_18525_+|NACHT-domain-containing-protein
MEDKGSGNMALSGDPMVDKALLDAGSAVGKEVFAKAWSLVTNAPQWIQKRYREKDPFGLEASRYCARVEERYNTMRIIGMSRPMQIRSIFVRVNILKKISAQRRSTIDELEQTLNKDQSGFGIVAETIDGQEVVDREPRLVLLGKPGGGKTTFLKWVALAAMDGKFHERRLPVFIPMKDWSDGTNTLRTCINEEFRVCGFEQPESFVDRLLDSGSLILLLDALDEINDNGRRSHALKEIRELSDKYPKIQIVISCRTAAYNYLFEQFVDVELADFQQQQVEQFVKQWFSDSSQKGALCLAELARDKNRAIRSLCQTPLLLTLMCLAFDEGMTFPSNRAELYKDALDALLKKWDTSRAVRRNTAYQQLSLAKKELLLGRIATTSFEDGRYFLRQDDVERQIKAFMTNLKGAPGDREPEVDPGEVLKEIEAQHGVLVERAKGIYSFSHLTFQEFFTARTLTENSNRDGPNQLVQEHSLEPRWREVFVLATGLLAEADSFVQAMRQRLTRLASENHGVSDFLNRNAALVHAAAGIPLPLRRALALAHVLERLAEAAQGYTSSLNASRELVEDMQLEFGRIKKIDVATIQTLKIGLNDARDGVDNLVQHVLKRDHGRVFDALVRYIQLTRLLVNCLNVDAYITLQVRESIVGSILAEK
>NZ_CP044550.1|WP_159597180.1|18556_19864_-|response-regulator
MKTLLVIEDDAIMGESLVQRFELEGLHVVWCRRLSEAADALETPPAAVVSDVRLPDGLATDWFVKLPASIRALPWFFLTGYGSVNDAVTAVRAGAREYLTKPFDIEHVVGLVHQAVSLSLAPEEDAVLGISPAMRRVEGMVRKVAGQRVSVLLTGDSGVGKEVAAQMIHTLDPRAGQREFVAVNCAAIPESMLEAEFFGYEKGAFSGAVRSHKGYLERANGGTLFLDEVGDLPASMQAKLLRALQEKCFFRLGAERTTHSDFRILAATNRDLYADMSAGTFREDLFYRLAVIKIALPPLRERPEDIRWLTERLLAQMVVEQGRPLAMSELFLRDVMAREWRGNVRELRSYLEQAVVMSDGGLLDEPLSVEYPDKSPSTASSDPIEPLQIILEGVERAHIRKALVHCEGSVGKTAEVLGISRKTLWEKMKKLAIAS
>NZ_CP044550.1|WP_159597181.1|19860_21306_-|sensor-histidine-kinase
MLGRLPYRVQIPLGLSLAVLIAAILVTGITARVSTQNARQEILSLLDRAVVLVIAQVRPMMVADDTWRVFALLRDTAELVPGAATGQARLAILDAEGRVFAASDPAKLETGRGLLGKPWRDQPTPTPSEIIDRQRLDQGDGSVVMVDPIRSEDGQTLGFVLTEVDAAVFAPDWPSLAKTALLAIALAVALLVPVGWWVGQRMTRPVGRLVAVIERIGREDPSKLRGAVPATKDPELSRIGDAVSQLMGELEQRKLAEDRALSAERLAAVGRMTAAVAHEINNPLAGLLTATQTLRLHGRSDDIRTRTLDLLDRGLQQIRTTVAALLPQARMDDRPLEPGDLEDIVTLVRVSASKLQVEIRFRVDVDSALRVPSAPLRQVMLNLLLNAMKAAGEHGVVSARLEADETQVTFCVTNSGPPLSAEKFRSTLAAESGRDPRGFGLWVCQELASHHGGRFELDTTQPGQTRLVFQVPNREAPEETT

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Crispr_ID: NZ_CP044550_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044550_2

159281-159379

Orphan

Consensus_repeat	Method
GGCCCACCTTGGGCCTCTGGCGGCCCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044550_2

>merge|NZ_CP044550|2|159281-159379|CRISPRCasFinder
GGCCCACCTTGGGCCTCTGGCGGCCCACATTGGGCCATTTCGCTTCCATCGATCAACACCGCACGCCTTGGTGGCCCACCTTGGGCCTCTGGTGGCCCA

>NZ_CP044550|2|2|159281-159379|CRISPRCasFinder
GGCCCACCTTGGGCCTCTGGCGGCCCA	CATTGGGCCATTTCGCTTCCATCGATCAACACCGCACGCCTTGGT
GGCCCACCTTGGGCCTCTGGTGGCCCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044550.1\|WP_159597297.1\|151426_151723_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|215527
NZ_CP044550.1\|WP_159597293.1\|148743_149879_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|366234
NZ_CP044550.1\|WP_159597304.1\|160647_161046_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044550.1\|WP_159597310.1\|168991_170272_-\|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl\|CDD\|239561
NZ_CP044550.1\|WP_159597296.1\|150938_151145_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044550.1\|WP_159597303.1\|159553_160627_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274757
NZ_CP044550.1\|WP_159597294.1\|149918_150386_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044550.1\|WP_159597308.1\|166944_167886_-\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|99782
NZ_CP044550.1\|WP_159597298.1\|152121_153384_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044550.1\|WP_159597302.1\|156495_157971_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|271177
NZ_CP044550.1\|WP_159597305.1\|161159_161459_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044550.1\|WP_159597295.1\|150547_150727_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044550.1\|WP_159597306.1\|164601_164955_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223787
NZ_CP044550.1\|WP_003049965.1\|161571_164487_-\|Tn3-like-element-IS1071-family-transposase	unknown	unknown	gnl\|CDD\|376561
NZ_CP044550.1\|WP_159597417.1\|165798_166707_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270296
NZ_CP044550.1\|WP_159597299.1\|153804_155475_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|226702
NZ_CP044550.1\|WP_159597307.1\|165002_165827_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP044550.1\|WP_159597300.1\|155655_156102_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224393
NZ_CP044550.1\|WP_159597309.1\|167963_168917_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP044550.1\|WP_159597301.1\|156316_156499_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP044550.1\|WP_159597297.1\|151426_151723_-\|hypothetical-protein	gnl\|CDD\|215527	PLN02976, PLN02976, amine oxidase.	0.00667363
NZ_CP044550.1\|WP_159597293.1\|148743_149879_-\|IS3-family-transposase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	1.84202e-33
NZ_CP044550.1\|WP_159597310.1\|168991_170272_-\|Rieske-2Fe-2S-domain-containing-protein	gnl\|CDD\|239561	cd03479, Rieske_RO_Alpha_PhDO_like, Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3,4-dioxygenase (CBDO), phenoxybenzoate dioxygenase (POB-dioxygenase) and 3-nitrobenzoate oxygenase (MnbA). ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to tolerate and utilize aromatic compounds for growth. The oxygenase alpha subunit contains an N-terminal Rieske domain with an [2Fe-2S] cluster and a C-terminal catalytic domain with a mononuclear Fe(II) binding site. The Rieske [2Fe-2S] cluster accepts electrons from a reductase or ferredoxin component and transfers them to the mononuclear iron for catalysis. PhDO and CBDO are two-component RO systems, containing oxygenase and reductase components. PhDO catalyzes the dihydroxylation of phthalate to form the 4,5-dihydro-cis-dihydrodiol of phthalate (DHD). CBDO, together with CbaC dehydrogenase, converts the environmental pollutant 3CBA to protocatechuate (PCA) and 5-Cl-PCA, which are then metabolized by the chromosomal PCA meta (extradiol) ring fission pathway. POB-dioxygenase catalyzes the initial catabolic step in the angular dioxygenation of phenoxybenzoate, converting mono- and dichlorinated phenoxybenzoates to protocatechuate and chlorophenols. These phenoxybenzoates are metabolic products formed during the degradation of pyrethroid insecticides.	7.71202e-81
NZ_CP044550.1\|WP_159597303.1\|159553_160627_+\|hypothetical-protein	gnl\|CDD\|274757	TIGR03739, PRTRC_D, PRTRC system protein D. A novel genetic system characterized by six major proteins, included a ParB homolog and a ThiF homolog, is designated PRTRC, or ParB-Related,ThiF-Related Cassette. It is often found on plasmids. This protein family is designated PRTRC system protein D. The gray zone, between trusted and noise, includes proteins found in the same genomes as other proteins of the PRTRC systems, but not in the same contiguous gene region.	4.59733e-47
NZ_CP044550.1\|WP_159597309.1\|167963_168917_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	7.53829e-126
NZ_CP044550.1\|WP_159597308.1\|166944_167886_-\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	gnl\|CDD\|99782	cd06185, PDR_like, Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur [2Fe-2S] cluster domain. Although structurally homologous to FNR, PDR binds FMN rather than FAD in it's FNR-like domain. Electron transfer between pyrimidines and iron-sulfur clusters (Rieske center [2Fe-2S]) or heme groups is mediated by flavins in respiration, photosynthesis, and oxygenase systems. Type I dioxygenase systems, including the hydroxylate phthalate system, have 2 components, a monomeric reductase consisting of a flavin and a 2Fe-2S center and a multimeric oxygenase. In contrast to other Rieske dioxygenases the ferredoxin like domain is C-, not N-terminal.	3.27779e-97
NZ_CP044550.1\|WP_159597307.1\|165002_165827_+\|hypothetical-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	9.40892e-30
NZ_CP044550.1\|WP_159597302.1\|156495_157971_-\|hypothetical-protein	gnl\|CDD\|271177	cd00796, INT_Rci_Hp1_C, Shufflon-specific DNA recombinase Rci and Bacteriophage Hp1_like integrase, C-terminal catalytic domain. Rci protein is a tyrosine recombinase specifically involved in Shufflon type of DNA rearrangement in bacteria. The shufflon of plasmid R64 consists of four invertible DNA segments which are separated and flanked by seven 19-bp repeat sequences. RCI recombinase facilitates the site-specific recombination between any inverted repeats results in an inversion of the DNA segment(s) either independently or in groups. HP1 integrase promotes site-specific recombination of the HP1 genome into that of Haemophilus influenza. Bacteriophage Hp1_like integrases are tyrosine based site specific recombinases. They belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	5.57502e-08
NZ_CP044550.1\|WP_003049965.1\|161571_164487_-\|Tn3-like-element-IS1071-family-transposase	gnl\|CDD\|376561	pfam01526, DDE_Tnp_Tn3, Tn3 transposase DDE domain. This family includes transposases of Tn3, Tn21, Tn1721, Tn2501, Tn3926 transposons from E-coli. The specific binding of the Tn3 transposase to DNA has been demonstrated. Sequence analysis has suggested that the invariant triad of Asp689, Asp765, Glu895 (numbering as in Tn3) may correspond to the D-D-35-E motif previously implicated in the catalysis of numerous transposases.	1.82742e-135
NZ_CP044550.1\|WP_159597306.1\|164601_164955_-\|hypothetical-protein	gnl\|CDD\|223787	COG0715, TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism].	1.4244e-06
NZ_CP044550.1\|WP_159597417.1\|165798_166707_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	4.6047e-127
NZ_CP044550.1\|WP_159597299.1\|153804_155475_+\|PAS-domain-containing-protein	gnl\|CDD\|226702	COG4251, COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms].	8.99508e-41
NZ_CP044550.1\|WP_159597300.1\|155655_156102_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224393	COG1476, COG1476, Predicted transcriptional regulators [Transcription].	9.94301e-08

>NZ_CP044550.1|WP_159597302.1|156495_157971_-|hypothetical-protein
MSDDDFELPDPREVNRKISEELRSGKLKERVIRRNTGALAKTVQQAQQRHKNDIVKQVVYVMTNEDLPVSTGRKRRMSEGSQSGVKEGLLRAARELKAERMAVRNLDELGRKHVLALIKRWMAEGQSYQNIQNKVSTLRTFTTMMGKPSMIPRNADYFDWLERAGVDLLERRKSKVALEPKTWTAKNVDPMGVIGKMRAEHPVVALCLEAMLAFGLRTREATHLEPIGGDLGDTLHIREGGRGGAKGGKSRTVPLSEDVALRIWQRDVLERAKVLARHHRQLKLAVPGKDYPKMLRHFYYVCEKYGVTRDGLGVLPHGLRHMYAGRRHLELTGLPPPVEGTVPMAVYRANADLVREGAQRLSLEMGHVRPTITGAYNGSVYTQSREEIVRAKAWLERIERCAGLKAMLDAFAVRTVYLGGKAAQGVRLLSGDSVRLLVEREGVSAEARDLELLQRAIAALLRPGDGLAVEVQDVSKCEDARDSYLELSVRG
>NZ_CP044550.1|WP_159597301.1|156316_156499_-|hypothetical-protein
MSEMKEKVNLQRDSRAEARDEHSFEMLLEVLQTQIAKLLLAGQDKTRSRPASAAEVARTQ
>NZ_CP044550.1|WP_159597300.1|155655_156102_-|helix-turn-helix-domain-containing-protein
MKREIARVARKEIKSEISALRKASASHRSDIAALKKIVKAQEALLRQFVRMANRADRESTVHHSKSEAAAPRAPLSAAAAAAFDHQAFVAHRKRLGLTQAQMAKLVGVSSLSIYKWESGKVMPRAAQREGVAQALKLGKRKALAIATS
>NZ_CP044550.1|WP_159597299.1|153804_155475_+|PAS-domain-containing-protein
MDPAPPFHTSAPHSSLLHTTSATWDEQPFFDAAPYAALLLNAQGEVVKHNRAFQETCAPADEAFAIGTDPVKVLGVRDEASALALRMRIGRALAGEVSLTLPLVLLRNPRVPVHVNATVSALQTPPGSLTGAFISLIPVAEPVAETVPGAQGVQVDEALFKAERRYRLMADALQDSCIFIVDAQGKISEWSESAHRLHGFTRDQIQGMSLSALHVVLHGEEEELSSHDALRLAAERGQWEVHGWRRRAHGEPFWGHTLLTALRGEDGTIEGLSCITRDMTVARDLDRVMNDLNAELERRVSERVRQYLVPNRDLDVFTHHITHDLRAPLRHINTFAGLIIEGTEDLSPHAELARYREGLRTGARRLDNMVESLLNYARLGRIDLHPAALAVSALVQSAIERVRCAYPGVAVSFVVQGDLPVVVGDAKMLGHLMFNVIENAVKFSARARSPEVQIGWSPEGDGLAQFFVVDNGVGFDVSKASNLFVMFSRQHHSIDFAGDGTGLAIAQRIVQRHNGRIWADSSPNTGCTVYFTLPVNGGTSSSTPGSLADLPLGPAG
>NZ_CP044550.1|WP_159597298.1|152121_153384_-|hypothetical-protein
MSKPSEQRKLVCDQQAATAPRKSNKRKSPSMRRLEHAAECETLMEQGWSVRQIALHLRCSKVHVVNQLLLAGAPSQVREMIAMEILSPSAALKAIRTHGDKAVDCIAQGMSVAAAQGKRRIPPRLIVAARTAGDTDSKCATCEAVRQLRHEQAIQQLPAALQQDQENAEQTTLSEQRTTRSENPKVEADETPLAAQNVLLPPAPEAASEPSGDECAEHADGQACLDNIDIEDFLTHPHWERMDDELHRLVEHVPQTSQRCERTTILSWLYQREGVSTFTMLADRIRGIESPIMRKRAMRRTLRTMERINLVSVITFAESNELAGKQLEELGRNSMITLTWTGMVWMRRAWQARANLARNRHSILQAHEMLVAEEEEGRGDEPIWVEGLAGVAPEVAKSSVRAITIGRGQITSVFDLGMKR
>NZ_CP044550.1|WP_159597297.1|151426_151723_-|hypothetical-protein
MMNAAYESDYASALDHMDFIVTSLAEKPGRAIALAVEHGGEYAVQALFDAVMDKGHRMVLVQALGAPSLPDWVREKLGVFLYGQNRQVAALLSKKVLH
>NZ_CP044550.1|WP_159597296.1|150938_151145_-|hypothetical-protein
MAENVHGLGWMPAIACEDMMFGSEGQMNFPADQRRLAYVKTHGSWPTDEQLIEFEGRLHGRPALTLVR
>NZ_CP044550.1|WP_159597295.1|150547_150727_-|hypothetical-protein
MTRFRHWLGGSRRSCRTSILGGKDEWATIRETAPQQLDQIDNDEREFNATFHRNESVQA
>NZ_CP044550.1|WP_159597294.1|149918_150386_-|hypothetical-protein
MIATIWGISTETGITMAKVVNIHLLVNSNKTAQIANRLNDALRNIVSPMGGGSAQGSFVLDYHLADLEGARPASKDVQLAIAKGRYKKGSAFQRRGVRRAYIDHYLLHINEDVEPDLMGAFGSEDAMLKAANCLHESHPDDGMYHMTCPPPAVPG
>NZ_CP044550.1|WP_159597293.1|148743_149879_-|IS3-family-transposase
MKKSRFTEEQIIGFLKQAEAGMPIKELCRNGGFSDATFYKWRAKFGGMQVSEAQRLRELESENAKLKRLLAEAHLDMHALKSVLGVKPLAPQARREAVGRMVSEHHLSERRACRLVGLSRDSYRHPPKADQATLDLHEKIVEIAHVRRRFGYRRIHDLLRPQFPGVNHKRVYRLYRQANLAVRRRKKSKRPINERVPLQLARTVNEVWSMDFVSDSLSGGRRLKYLTVADDFSHESVDIVVDFGISGQYVTRILDRAALFRGYPQAVRTDNGPEFTSRAFMAWAQAHGIRHILIQPGRPMQNGYIESFNGKFRDEHLNECWFQTLHQARTAVAIWRTDYNEVRPHSSLGRMPPARFAELHRQRAGDAALPTSTQTPIE
>NZ_CP044550.1|WP_159597303.1|159553_160627_+|hypothetical-protein
MHRDMKTTVLASCAVDVGYANVKYSSGRAHVGGQVEIRTGVFPALAPVLSNDGFQIRGDSPAADGTVVTLGGTRYFSGKGVHFHASGSEPRTVPSNYCETDEYMALLCGALHYIAKDAGANHSMVIETLVLGLPLSTWRQHHKALAARATGEHVLGTFGGGDLKCLVHVKHVTVIVQPLGALYHHGIGASEKPMAGWTMVVDAGGGTLDWFVSQRMQPNWPRSGAHNKSMLACCYAVADQINPDWKDQIEIVNRIDFALRNSSDHFEVQGVRYPLDKYRAAVEAVLRESVNKMMASVNKTDNLDYILVTGGAAGIFYTFLCDNYPNLKPVMHVDPDNLYANVKGFQIAAELVHEEVR
>NZ_CP044550.1|WP_159597304.1|160647_161046_+|hypothetical-protein
MAKASSEKVGNDEVRHGELRTRIRLPAAMGRVYDHLIAMPSLQRGKRIQQLIVLGYLYEAQFFPATDAGPATMGMPPPEPLMQASKRRNHGSSRSLPASESHAKKAVADSLVASRATARERIGSPFALLPID
>NZ_CP044550.1|WP_159597305.1|161159_161459_+|hypothetical-protein
MPYVTELDMTTADFRQHYTPDPHWLLETAFGRDLLKMRLRQVEPGLQVPEWKYAAHLDPKLERMVDDLGLRETAQPSTVLETLKFMKLASGSPRFQCNK
>NZ_CP044550.1|WP_003049965.1|161571_164487_-|Tn3-like-element-IS1071-family-transposase
MQGWHTTFLGMRGLPRDISDFEMKAFFTFDGAERDAINARRGDSHKLGLALHIGFLRMSGRLLGAFRVIPVALWRHLGNELGIAAPEVASLRAMYERGRTLFDHQQVACTVLGFQWMSEHQRRSLVRELRDEVARCADRDQLLVRARQWLYKNKLVIVHERAIRTLIAAALAQLEVETGTAIAASVDPATLDRWRASVSELRPDGQTQQSWLWAAPAKHSTRQISEVLERIDLLYTLDVHKHLADIPDLILRRYARRLVSRPPSAGAKIKEPARTVEVACFLRYCLFTTTDQLILMVQRRIADLWRQAAADVPATVNWAAMYKTLLGELVALSAQGAVPDAELRARLEALITETQKRKPPSRASLVREGLIDGIRPVRSLLVAIAKLPWQATGEHPAIEYLAKLQALYLKGSRKLPVEVVAPSLGMIWQVSISSPDRERAFQALEVATLFALRRAVRNGSVWIEHSLSFRGRARLFFTDERWQAESKKHYARLSLPSKAATFLKPLLARVTAGVDAVAAAARSGVLRVDDELHLSPLPAEDEDPEVTKLRAALDHRIGEVQLPEVILAVDAQVRFSWIMLGREPRSTDELLMVYAGIMAHGTSLTAVECARMIPQLSATSIRQAMRWARDERRLSQACQAVLEFMQRHPIAATWGRSDLASSDMMSMETTKRVWQARLDPRRNTPSIGIYSHVKDRWGIFHAQPFVLNERQAGVAIEGVIRQEKLETSQLAVDTHGYTDFAMSHARLLGFDLCPRLKELKQRHLFVPRGTKVPAEIAAVCEANVDVALIEKHWDSLVHLAASVMSGHASAVAALARFGSAAQGDPIYEAGVQLGRLLRTAFLADYFVKDAFRNELRRVLNRGEAVNALKRAIYTGRISPAQAKRVDEMQAVADALSLMANIVMAWNTSQMQAVLDRWSNRRQVIPPELIGKIAPTRLESINLRGVFRFPVDRYADQILPSRPNASITGTNG
>NZ_CP044550.1|WP_159597306.1|164601_164955_-|hypothetical-protein
MPCAGRGRWGDHPDPHVRGSNQQPATLTVSAQLVKERPDLVDRYVAQIVNAARWSQANRVPTVQSFANEVGTSYEWAEAAYGPRSHELLTPSLDVELVAAAKPTRSFWGSPRFQCNK
>NZ_CP044550.1|WP_159597307.1|165002_165827_+|hypothetical-protein
MLPHDRAGHPRLREAVANRVRLVRGGVQVVPFPCMAGSTAALPSAKLAICCPADFAFTGEPWSADALAELVGWSRKHAGWLVEDDRDLDLYETGPHEAVLARGASAERTIYLGSFERSVFPEVGCGFIVAPHELVQSFSAAAQQQAYNSPLQMQRTLFDFITQGYIGRHANRLRKAHGERRKAALAALRRGAFTGDLSFQAAGSYLVASFRNVSEPGLLERALEENRVGARVLARPGRREQLLLVGYAGAPREELFAAIGVLDALLTRSCRRVT
>NZ_CP044550.1|WP_159597417.1|165798_166707_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MPAFANTFPTQPVRFIVPFPPGGSADALTRMLAQRMQAAWGQAVVVENKPGGTVIGTDLVAKAAPDGHTIALVIPSLAVNPSIMAQLPYDTVKDLAGVTLISTLPIALFATPSLPVNNVAELVAYAKKNPKTLSYGSARLGSTSHLAGLMLNQLAGVDLVHVPYKGSAPAQQDLIGGRLTLLFDSFISQLPMVQAGRVKLVAPAGPRRLPGFPDAAPIGDTVKGFNVESYFGVIAPRATPPAVLAQIHQAIKKAMEDPAVSSWMATQGMVPAASTPAQFDAFIQADMKKWAAVVKSLGGKIA
>NZ_CP044550.1|WP_159597308.1|166944_167886_-|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein
MKARVHSITYGADDVLIYDIRSADGQQLPPFEAGAHIDVTIPGGIVRSYSLANDPSDRHRYVVGVKREAQGRGGSASMHAHVQAGTLLDIAGPRNNFALEEDAAHSVFIAGGIGITPLWSMAQRLEALRKPWTMYMRGRSRKTTAFLDCLSSPRLGGRVHVSFSEDAGTPRLDIHSIVAKAPKGAHIYCCGPESMLECVESACVHLPKERLHLERFKAKEMQSRDGGYLVRLARSNQEIRIQKGCTILESLRQRGIPVQSSCQQGVCGACETAVLAGRPDHRDCVLSEEERTHGKSMLICCSGSLTEELVLDL
>NZ_CP044550.1|WP_159597309.1|167963_168917_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MALFASAILCNAHAQTKEVWPSKPVRFVVPFTAGGSIDVLARLVGRHLETRLNQPIVVENRTGAGGTVGTDLVARAPADGYTLLFTAQGPLVLNPFLMKRLPYDATTFAPVTVVVEAPNVLVASRQLPVSSFEELRNFAKANPEKMTFATQGIGTTGHVTGELINQQAGTALTHVAYQGFPPALTDVLAGRVSLMIGDTINLVPRIVSGQLRPIAIASTRRSAVLPNVPTFAEAGYPAIVSGPWYAVVAPAGTPIEIRHKLADEIRQVLGLREVQDKLKELGVEARGLSPEEFDVYLKSEYKRWGGVIQKAGISLDK
>NZ_CP044550.1|WP_159597310.1|168991_170272_-|Rieske-2Fe-2S-domain-containing-protein
MSNSESNETLTRMGPGAAMGRVFRQFWQPALLSEELPVADCPPVRVRLMGEDFVAFRDSSGKVGLLDAHCPHRLADLFFGRNEEGGLRCVYHGWKFSVAGEILDMPSEPQGSPMRCNPNLRAKAYPVREAGGIIWAYLGPQESMPALPDMEFMSLPPQNVHVSKCLMKCNYLQALEGSIDTAHLTFLHHSMAPMEKDVFAVGNLQEFGDADGAPRFFCEDTDFGMRISARRDGGNGNYYWRITQWLMPNYVLVPTAEGLVCRANLFIAIDDENCWWYRVRYHVGRPLGSDELAEYKTGNLDYARLIPGTYIPQGNRANDYLMDRDLQRRGSFTGIPSAQLQDLAVQESQGPIADRTKEHLGTSDTAIVKCRRRLLEVAKKFANDGTVPTAAKRGELYKHRAIAILLPMDITPEQAGSHPATVPDAR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP044550_1	1.1\|8383\|26\|NZ_CP044550\|CRISPRCasFinder	8383-8408	26	NZ_CP044550	Hydrogenophaga sp. BPS33 plasmid pBPS33-1, complete sequence	8383-8408	0	1.0
NZ_CP044550_2	2.1\|159308\|45\|NZ_CP044550\|CRISPRCasFinder	159308-159352	45	NZ_CP044550	Hydrogenophaga sp. BPS33 plasmid pBPS33-1, complete sequence	159308-159352	0	1.0

1. spacer 1.1|8383|26|NZ_CP044550|CRISPRCasFinder matches to NZ_CP044550 (Hydrogenophaga sp. BPS33 plasmid pBPS33-1, complete sequence) position: , mismatch: 0, identity: 1.0

ttttgagatatcatattctcaaatgc	CRISPR spacer
ttttgagatatcatattctcaaatgc	Protospacer
**************************

2. spacer 2.1|159308|45|NZ_CP044550|CRISPRCasFinder matches to NZ_CP044550 (Hydrogenophaga sp. BPS33 plasmid pBPS33-1, complete sequence) position: , mismatch: 0, identity: 1.0

cattgggccatttcgcttccatcgatcaacaccgcacgccttggt	CRISPR spacer
cattgggccatttcgcttccatcgatcaacaccgcacgccttggt	Protospacer
*********************************************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

82505 : 149879

Shigella_phage(28.57%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_159595278.1\|82505_82790_+\|transposase	transposase	U5P4I9	Shigella_phage	6.2e-14	49.4
WP_159590796.1\|82801_83641_+\|transposase	IS3 family transposase	U5P429	Shigella_phage	3.5e-81	56.2
WP_159597175.1\|84585_85962_-\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	9.3e-39	31.2
WP_159590796.1\|86330_87170_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	3.5e-81	56.2
WP_159595278.1\|87181_87466_-\|transposase	transposase	U5P4I9	Shigella_phage	6.2e-14	49.4
WP_159597246.1\|87937_88972_+	porin	NA	NA	NA	NA
WP_159597247.1\|90407_90752_+	CzcE family metal-binding protein	NA	NA	NA	NA
WP_159597248.1\|91072_91765_+	heavy metal response regulator transcription factor	W8CYM9	Bacillus_phage	3.0e-30	34.8
WP_159597249.1\|91819_93151_+	heavy metal sensor histidine kinase	W8CYF6	Bacillus_phage	1.1e-12	22.3
WP_159597250.1\|93162_93447_-	CopK family periplasmic copper-binding protein	NA	NA	NA	NA
WP_159597251.1\|93574_95122_-	hypothetical protein	NA	NA	NA	NA
WP_159597252.1\|95542_96532_+	porin	NA	NA	NA	NA
WP_159597253.1\|96664_97012_+	hypothetical protein	NA	NA	NA	NA
WP_159597254.1\|96992_97679_+	heavy metal response regulator transcription factor	W8CYM9	Bacillus_phage	2.8e-28	33.6
WP_159597255.1\|97675_99010_+	heavy metal sensor histidine kinase	NA	NA	NA	NA
WP_159597256.1\|99235_99580_+	CzcE family metal-binding protein	NA	NA	NA	NA
WP_159597257.1\|99683_102158_-	heavy metal translocating P-type ATPase	E4ZFI9	Streptococcus_phage	4.9e-115	39.6
WP_159597258.1\|102492_103548_+	porin	NA	NA	NA	NA
WP_159597259.1\|103707_104460_-	hypothetical protein	NA	NA	NA	NA
WP_159597260.1\|105222_107295_+	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_159597261.1\|107688_108030_+	CzcE family metal-binding protein	NA	NA	NA	NA
WP_159597262.1\|108256_109531_+	TolC family protein	NA	NA	NA	NA
WP_159597415.1\|109556_110843_+	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_159597263.1\|110855_114062_+	CusA/CzcA family heavy metal efflux RND transporter	S5VTK5	Leptospira_phage	7.1e-74	24.4
WP_159597264.1\|114304_114991_+	heavy metal response regulator transcription factor	W8CYM9	Bacillus_phage	9.7e-29	34.4
WP_137922426.1\|117200_118595_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_159597265.1\|118956_119283_-	hypothetical protein	NA	NA	NA	NA
WP_159597266.1\|119514_119871_-	XRE family transcriptional regulator	NA	NA	NA	NA
WP_159597267.1\|119851_120241_-	addiction module toxin RelE	NA	NA	NA	NA
WP_159597268.1\|120257_120479_-	hypothetical protein	NA	NA	NA	NA
WP_159597269.1\|120686_120965_-	hypothetical protein	NA	NA	NA	NA
WP_159597270.1\|121674_123546_-	hypothetical protein	NA	NA	NA	NA
WP_159597271.1\|123542_124058_-	hypothetical protein	NA	NA	NA	NA
WP_159597272.1\|124045_125047_-	hypothetical protein	NA	NA	NA	NA
WP_159597273.1\|125385_126675_+	DUF3883 domain-containing protein	NA	NA	NA	NA
WP_159597274.1\|127244_128051_+	hypothetical protein	NA	NA	NA	NA
WP_159597275.1\|128394_130905_-	DUF4238 domain-containing protein	NA	NA	NA	NA
WP_159597276.1\|130969_133318_-	AAA family ATPase	NA	NA	NA	NA
WP_159597277.1\|133912_134722_+	hypothetical protein	NA	NA	NA	NA
WP_159597278.1\|134746_136738_+	hypothetical protein	NA	NA	NA	NA
WP_159597279.1\|136780_137008_+	hypothetical protein	NA	NA	NA	NA
WP_159597280.1\|137316_138273_-	hypothetical protein	NA	NA	NA	NA
WP_159597281.1\|138315_138522_+	hypothetical protein	NA	NA	NA	NA
WP_159597282.1\|138863_139187_-	transcriptional regulator	NA	NA	NA	NA
WP_159597283.1\|139176_139560_-	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_159597416.1\|141069_141339_+	hypothetical protein	NA	NA	NA	NA
WP_159597284.1\|141579_142176_+	hypothetical protein	NA	NA	NA	NA
WP_159597285.1\|142168_143218_+	nucleotidyl transferase AbiEii/AbiGii toxin family protein	NA	NA	NA	NA
WP_159597286.1\|143373_144060_-	hypothetical protein	NA	NA	NA	NA
WP_159597287.1\|144178_145429_-	HNH endonuclease	A0A1S6KZY3	Salmonella_phage	1.1e-17	35.4
WP_159597288.1\|145741_145960_-	hypothetical protein	Q6QIC9	Burkholderia_phage	5.1e-08	46.2
WP_159597289.1\|146601_147072_+	hypothetical protein	NA	NA	NA	NA
WP_159597290.1\|147135_147567_+	hypothetical protein	NA	NA	NA	NA
WP_159597291.1\|147909_148125_+	hypothetical protein	NA	NA	NA	NA
WP_159597292.1\|148268_148685_-	hypothetical protein	NA	NA	NA	NA
WP_159597293.1\|148743_149879_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	9.3e-53	43.5

DBSCAN-SWA_2

161571 : 228982

Salmonella_phage(83.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003049965.1\|161571_164487_-\|transposase	Tn3-like element IS1071 family transposase	A0A1B0V7H9	Salmonella_phage	1.4e-52	24.0
WP_159597306.1\|164601_164955_-	hypothetical protein	NA	NA	NA	NA
WP_159597307.1\|165002_165827_+	hypothetical protein	NA	NA	NA	NA
WP_159597417.1\|165798_166707_-	tripartite tricarboxylate transporter substrate binding protein	NA	NA	NA	NA
WP_159597308.1\|166944_167886_-	2Fe-2S iron-sulfur cluster binding domain-containing protein	NA	NA	NA	NA
WP_159597309.1\|167963_168917_-	tripartite tricarboxylate transporter substrate binding protein	NA	NA	NA	NA
WP_159597310.1\|168991_170272_-	Rieske 2Fe-2S domain-containing protein	NA	NA	NA	NA
WP_159597311.1\|170361_170841_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_159597312.1\|170868_171204_-	hypothetical protein	NA	NA	NA	NA
WP_159597313.1\|171217_172087_-	UPF0280 family protein	NA	NA	NA	NA
WP_003158660.1\|172380_175296_-\|transposase	Tn3-like element IS1071 family transposase	A0A1B0V7H9	Salmonella_phage	1.4e-52	24.0
WP_159597306.1\|175410_175764_-	hypothetical protein	NA	NA	NA	NA
WP_159597307.1\|175811_176636_+	hypothetical protein	NA	NA	NA	NA
WP_159597308.1\|177754_178696_-	2Fe-2S iron-sulfur cluster binding domain-containing protein	NA	NA	NA	NA
WP_159597309.1\|178773_179727_-	tripartite tricarboxylate transporter substrate binding protein	NA	NA	NA	NA
WP_159597310.1\|179800_181081_-	Rieske 2Fe-2S domain-containing protein	NA	NA	NA	NA
WP_159597311.1\|181170_181650_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_159597312.1\|181677_182013_-	hypothetical protein	NA	NA	NA	NA
WP_159597313.1\|182026_182896_-	UPF0280 family protein	NA	NA	NA	NA
WP_159597306.1\|186223_186577_-	hypothetical protein	NA	NA	NA	NA
WP_159597307.1\|186624_187449_+	hypothetical protein	NA	NA	NA	NA
WP_159597417.1\|187420_188329_-	tripartite tricarboxylate transporter substrate binding protein	NA	NA	NA	NA
WP_159597308.1\|188566_189508_-	2Fe-2S iron-sulfur cluster binding domain-containing protein	NA	NA	NA	NA
WP_159597309.1\|189585_190539_-	tripartite tricarboxylate transporter substrate binding protein	NA	NA	NA	NA
WP_159597310.1\|190613_191894_-	Rieske 2Fe-2S domain-containing protein	NA	NA	NA	NA
WP_159597311.1\|191983_192463_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_159597312.1\|192490_192826_-	hypothetical protein	NA	NA	NA	NA
WP_159597313.1\|192839_193709_-	UPF0280 family protein	NA	NA	NA	NA
WP_003049965.1\|194002_196918_-\|transposase	Tn3-like element IS1071 family transposase	A0A1B0V7H9	Salmonella_phage	1.4e-52	24.0
WP_159597314.1\|197461_198211_+	electron transfer flavoprotein subunit beta/FixA family protein	NA	NA	NA	NA
WP_159597315.1\|198222_199158_+	electron transfer flavoprotein subunit alpha/FixB family protein	NA	NA	NA	NA
WP_159597316.1\|200751_201896_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	9.8e-42	37.4
WP_028604925.1\|203721_204528_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_159597317.1\|204634_205615_+	tripartite tricarboxylate transporter substrate binding protein	NA	NA	NA	NA
WP_028604927.1\|205642_206806_+	butyryl-CoA dehydrogenase	NA	NA	NA	NA
WP_159597318.1\|206819_207593_+	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
WP_159597319.1\|207589_208729_+	thiolase family protein	NA	NA	NA	NA
WP_159597320.1\|208738_209146_+	DNA-binding protein	NA	NA	NA	NA
WP_159597321.1\|209135_210356_+	CoA transferase	NA	NA	NA	NA
WP_159597322.1\|211968_212646_+	3-oxoacid CoA-transferase subunit A	NA	NA	NA	NA
WP_028604935.1\|212654_213293_+	3-oxoacid CoA-transferase subunit B	NA	NA	NA	NA
WP_028604936.1\|213966_214800_-	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_003049965.1\|215257_218173_-\|transposase	Tn3-like element IS1071 family transposase	A0A1B0V7H9	Salmonella_phage	1.4e-52	24.0
WP_159597306.1\|218287_218641_-	hypothetical protein	NA	NA	NA	NA
WP_159597307.1\|218688_219513_+	hypothetical protein	NA	NA	NA	NA
WP_159597417.1\|219484_220393_-	tripartite tricarboxylate transporter substrate binding protein	NA	NA	NA	NA
WP_159597308.1\|220630_221572_-	2Fe-2S iron-sulfur cluster binding domain-containing protein	NA	NA	NA	NA
WP_159597309.1\|221649_222603_-	tripartite tricarboxylate transporter substrate binding protein	NA	NA	NA	NA
WP_159597310.1\|222677_223958_-	Rieske 2Fe-2S domain-containing protein	NA	NA	NA	NA
WP_159597311.1\|224047_224527_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_159597312.1\|224554_224890_-	hypothetical protein	NA	NA	NA	NA
WP_159597313.1\|224903_225773_-	UPF0280 family protein	NA	NA	NA	NA
WP_003049965.1\|226066_228982_-\|transposase	Tn3-like element IS1071 family transposase	A0A1B0V7H9	Salmonella_phage	1.4e-52	24.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_CP044549

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP044549_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044549_1

1245736-1245846

Orphan

Consensus_repeat	Method
CATCACTCCCTCTCCCGCTTGCGGGAGAGGGTTGGGGTGAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044549_1

>merge|NZ_CP044549|1|1245736-1245846|CRISPRCasFinder
CATCACTCCCTCTCCCGCTTGCGGGAGAGGGTTGGGGTGAGGCAAATCGAATGCATCTGCGCAGCGACCATCTACTCCCTCTCCCGCTTGCGGGAGAGGGTTGGGGTGAGG

>NZ_CP044549|1|1|1245736-1245846|CRISPRCasFinder
CATCACTCCCTCTCCCGCTTGCGGGAGAGGGTTGGGGTGAGG	CAAATCGAATGCATCTGCGCAGCGACC
ATCTACTCCCTCTCCCGCTTGCGGGAGAGGGTTGGGGTGAGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044549.1\|WP_159590297.1\|1244304_1245732_+\|benzoyl-CoA-2,3-epoxidase-subunit-BoxB	unknown	unknown	gnl\|CDD\|200253
NZ_CP044549.1\|WP_159590285.1\|1234696_1235131_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|224523
NZ_CP044549.1\|WP_159590301.1\|1247542_1248175_+\|uracil-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234653
NZ_CP044549.1\|WP_159590295.1\|1242601_1244269_+\|benzoyl-CoA-dihydrodiol-lyase	unknown	unknown	gnl\|CDD\|181274
NZ_CP044549.1\|WP_159590305.1\|1250926_1251346_+\|globin	unknown	unknown	gnl\|CDD\|381282
NZ_CP044549.1\|WP_159590283.1\|1233956_1234700_+\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153212
NZ_CP044549.1\|WP_159590309.1\|1253093_1254290_+\|lipid-transfer-protein	unknown	unknown	gnl\|CDD\|181327
NZ_CP044549.1\|WP_159590315.1\|1256399_1257188_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187629
NZ_CP044549.1\|WP_159590293.1\|1239746_1241324_-\|3,4-dehydroadipyl-CoA-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|237016
NZ_CP044549.1\|WP_159590317.1\|1257203_1259948_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|225461
NZ_CP044549.1\|WP_159590291.1\|1238133_1239717_-\|benzoate-CoA-ligase-family-protein	unknown	unknown	gnl\|CDD\|341269
NZ_CP044549.1\|WP_159590313.1\|1255202_1256387_+\|lipid-transfer-protein	unknown	unknown	gnl\|CDD\|181327
NZ_CP044549.1\|WP_159590289.1\|1237025_1238018_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP044549.1\|WP_159596832.1\|1241523_1242444_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|236167
NZ_CP044549.1\|WP_159590287.1\|1235168_1237019_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|227590
NZ_CP044549.1\|WP_159590311.1\|1254329_1255166_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187594
NZ_CP044549.1\|WP_159590303.1\|1248355_1250917_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|225669
NZ_CP044549.1\|WP_159590307.1\|1251472_1253038_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|223395
NZ_CP044549.1\|WP_159590281.1\|1232297_1233818_-\|integrin	unknown	unknown	gnl\|CDD\|316802
NZ_CP044549.1\|WP_159590299.1\|1245919_1247221_+\|benzoyl-CoA-2,3-epoxidase-subunit-BoxA	unknown	unknown	gnl\|CDD\|132268

Protein	Function_ID	Function_description	E-value
NZ_CP044549.1\|WP_159590297.1\|1244304_1245732_+\|benzoyl-CoA-2,3-epoxidase-subunit-BoxB	gnl\|CDD\|200253	TIGR03225, benzo_boxB, benzoyl-CoA oxygenase, B subunit. Members of this protein family are BoxB, the B subunit of benzoyl-CoA oxygenase. This oxygen-requiring enzyme acts in an aerobic pathway of benzoate catabolism via coenzyme A ligation. [Energy metabolism, Other].	0
NZ_CP044549.1\|WP_159590285.1\|1234696_1235131_-\|acyl-CoA-thioesterase	gnl\|CDD\|224523	COG1607, COG1607, Acyl-CoA hydrolase [Lipid metabolism].	2.7784e-47
NZ_CP044549.1\|WP_159590301.1\|1247542_1248175_+\|uracil-phosphoribosyltransferase	gnl\|CDD\|234653	PRK00129, upp, uracil phosphoribosyltransferase; Reviewed.	6.5042e-132
NZ_CP044549.1\|WP_159590295.1\|1242601_1244269_+\|benzoyl-CoA-dihydrodiol-lyase	gnl\|CDD\|181274	PRK08184, PRK08184, benzoyl-CoA-dihydrodiol lyase; Provisional.	0
NZ_CP044549.1\|WP_159590305.1\|1250926_1251346_+\|globin	gnl\|CDD\|381282	cd14773, TrHb2_PhHbO-like_O, Truncated hemoglobins, group 2 (O); Pseudoalteromonas haloplanktis PhHbO like. The M- and S families exhibit the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments. Truncated hemoglobins (TrHbs, 2/2Hb, or 2/2 globins) or the T family globins adopt a 2-on-2 alpha-helical sandwich structure, resulting from extensive and complex modifications of the canonical 3-on-3 alpha-helical sandwich that are distributed throughout the whole protein molecule. TrHbs are classified into three main groups based on their structural properties and named after Mycobacterium sp. genes glbN, glbO, and glbP: TrHb1s (N), TrHb2s (O) and TrHb3s (P). TrHb2's belonging to this group include Pseudoalteromonas haloplanktis PhHbO (encoded by the PSHAa0030 gene) which appears to be involved in oxidative and nitrosative stress resistance.	3.07548e-65
NZ_CP044549.1\|WP_159590283.1\|1233956_1234700_+\|type-1-glutamine-amidotransferase	gnl\|CDD\|153212	cd01741, GATase1_1, Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. This group contains a subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. GATase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. Glutamine amidotransferases (GATase) includes the triad family of amidotransferases which have a conserved Cys-His-Glu catalytic triad in the glutaminase active site. In this subgroup this triad is conserved. GATase activity can be found in a range of biosynthetic enzymes, including: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase , anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. Glutamine amidotransferase (GATase) domains can occur either as single polypeptides, as in glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.	2.80552e-49
NZ_CP044549.1\|WP_159590309.1\|1253093_1254290_+\|lipid-transfer-protein	gnl\|CDD\|181327	PRK08256, PRK08256, lipid-transfer protein; Provisional.	0
NZ_CP044549.1\|WP_159590315.1\|1256399_1257188_+\|SDR-family-oxidoreductase	gnl\|CDD\|187629	cd05371, HSD10-like_SDR_c, 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs. HSD10, also known as amyloid-peptide-binding alcohol dehydrogenase (ABAD), was previously identified as a L-3-hydroxyacyl-CoA dehydrogenase, HADH2. In fatty acid metabolism, HADH2 catalyzes the third step of beta-oxidation, the conversion of a hydroxyl to a keto group in the NAD-dependent oxidation of L-3-hydroxyacyl CoA. In addition to alcohol dehydrogenase and HADH2 activites, HSD10 has steroid dehydrogenase activity. Although the mechanism is unclear, HSD10 is implicated in the formation of amyloid beta-petide in the brain (which is linked to the development of Alzheimer's disease). Although HSD10 is normally concentrated in the mitochondria, in the presence of amyloid beta-peptide it translocates into the plasma membrane, where it's action may generate cytotoxic aldehydes and may lower estrogen levels through its use of 17-beta-estradiol as a substrate. HSD10 is a member of the SRD family, but differs from other SDRs by the presence of two insertions of unknown function. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	4.36073e-101
NZ_CP044549.1\|WP_159590293.1\|1239746_1241324_-\|3,4-dehydroadipyl-CoA-semialdehyde-dehydrogenase	gnl\|CDD\|237016	PRK11903, PRK11903, 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase.	0
NZ_CP044549.1\|WP_159590317.1\|1257203_1259948_-\|AAA-family-ATPase	gnl\|CDD\|225461	COG2909, MalT, ATP-dependent transcriptional regulator [Transcription].	1.47675e-89
NZ_CP044549.1\|WP_159590291.1\|1238133_1239717_-\|benzoate-CoA-ligase-family-protein	gnl\|CDD\|341269	cd05959, BCL_4HBCL, Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase). Benzoate CoA ligase and 4-hydroxybenzoate-coenzyme A ligase catalyze the first activating step for benzoate and 4-hydroxybenzoate catabolic pathways, respectively. Although these two enzymes share very high sequence homology, they have their own substrate preference. The reaction proceeds via a two-step process; the first ATP-dependent step forms the substrate-AMP intermediate, while the second step forms the acyl-CoA ester, releasing the AMP. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Some bacteria can use benzoic acid or benzenoid compounds as the sole source of carbon and energy through degradation. Benzoate CoA ligase and 4-hydroxybenzoate-Coenzyme A ligase are key enzymes of this process.	0
NZ_CP044549.1\|WP_159590313.1\|1255202_1256387_+\|lipid-transfer-protein	gnl\|CDD\|181327	PRK08256, PRK08256, lipid-transfer protein; Provisional.	0
NZ_CP044549.1\|WP_159590289.1\|1237025_1238018_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	1.93553e-108
NZ_CP044549.1\|WP_159596832.1\|1241523_1242444_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|236167	PRK08154, PRK08154, anaerobic benzoate catabolism transcriptional regulator; Reviewed.	8.04427e-156
NZ_CP044549.1\|WP_159590287.1\|1235168_1237019_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|227590	COG5265, ATM1, ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP044549.1\|WP_159590311.1\|1254329_1255166_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187594	cd05333, BKR_SDR_c, beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs. This subgroup includes the Escherichai coli K12 BKR, FabG. BKR catalyzes the NADPH-dependent reduction of ACP in the first reductive step of de novo fatty acid synthesis (FAS). FAS consists of four elongation steps, which are repeated to extend the fatty acid chain through the addition of two-carbo units from malonyl acyl-carrier protein (ACP): condensation, reduction, dehydration, and a final reduction. Type II FAS, typical of plants and many bacteria, maintains these activities on discrete polypeptides, while type I FAS utilizes one or two multifunctional polypeptides. BKR resembles enoyl reductase, which catalyzes the second reduction step in FAS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet) NAD(P)(H) binding region and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H) binding pattern: TGxxxGxG in classical SDRs. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P) binding motif and an altered active site motif (YXXXN). Fungal type type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P) binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr-151 and Lys-155, and well as Asn-111 (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	1.32637e-76
NZ_CP044549.1\|WP_159590303.1\|1248355_1250917_+\|FtsX-like-permease-family-protein	gnl\|CDD\|225669	COG3127, COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	0
NZ_CP044549.1\|WP_159590307.1\|1251472_1253038_+\|AMP-binding-protein	gnl\|CDD\|223395	COG0318, CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	6.43359e-119
NZ_CP044549.1\|WP_159590281.1\|1232297_1233818_-\|integrin	gnl\|CDD\|316802	pfam14312, FG-GAP_2, FG-GAP repeat.	1.79436e-08
NZ_CP044549.1\|WP_159590299.1\|1245919_1247221_+\|benzoyl-CoA-2,3-epoxidase-subunit-BoxA	gnl\|CDD\|132268	TIGR03224, benzo_boxA, benzoyl-CoA oxygenase/reductase, BoxA protein. Members of this protein family are BoxA, the A component of the BoxAB benzoyl-CoA oxygenase/reductase. This oxygen-requiring enzyme acts in an aerobic pathway of benzoate catabolism via coenzyme A ligation. BoxA is a homodimeric iron-sulphur-flavoprotein and acts as an NADPH-dependent reductase for BoxB. [Energy metabolism, Other].	0

>NZ_CP044549.1|WP_159590297.1|1244304_1245732_+|benzoyl-CoA-2,3-epoxidase-subunit-BoxB
MSTINYSEKIPNNVNLSEDRTLQRALEGWQPNFINWWDDVGPEGSTNHEVYLRTAVSVDPQGWAQFGHVKMRDYRWGIFLNPGDAERKIHFGDNLGEKAWQDVPGEHRANLRRIIVTQGDTEPASVEQQRHLGLTAPSMYDLRNLFQINVEEGRHLWAMVYLLHKHFGRDGREEAEALLQRTSGDQDNPRILGAFNEKTPDWLAFFMFTYFTDRDGKFQLSALAESAFDPLARTTKFMLTEEAHHMFVGESGVSRVLTRTAQVMNELKTDDPAKVRAAGAIDLGTIQRYLNFHYSVTIDLFGADQSSNAAIFYSSGLKGRYEEGKRSDDHVLKGQTYKVLEVKDGKLVEKDVPMLNALNEVLRDDFIADSVAGVNRWNKVLEKAGIPTRLTVPHKAFNRQIGALAGIKMSPDGRVVSEAEWEAKKSEWLPTPEDFAFVASLMGRVVDPGKFAGWIAPPVMGINRQPVDFEYVRFG
>NZ_CP044549.1|WP_159590295.1|1242601_1244269_+|benzoyl-CoA-dihydrodiol-lyase
MSATATPPAVDYRTQPDQYRHVKLAFDGAIATLSIDIDEDAGIRPGYKLKLNSYDLGVDIELHDALNRVRFEHPEVRTVVVTSAKDRVFCSGANIFMLGLSSHAWKVNFCKFTNETRNGIEDSSKYSGLRFVAALNGACAGGGYELALACDEIVLVDDRSSAVSLPEVPLLGVLPGTGGLTRVTDKRHVRHDLADIFCTTSEGVRGQKAVDWRLVDSIVKPQKFAEHVKERATALAAQSDRPANGKGVALPRVERKDSADGIHYAYVNVAIDRAKRNVTITVKAPTGAQPKDIAGIEAAGTAWWPLQMARELDDAILCLRTNELDMGTWLLKTEGDAAAVLASDALMLANKDHWFVRETLGLMRRTFARLDVSSRSLFALIESGSCFAGSLAELAFCADRAYMLALPDDADAAPKMQLGEFNFGYLPMVNEQSRLQRRFYEETGPMEAARGAIGKALDADAALALGLVTAAPDDIDWADEVRMAMEERAAMSPDALTGLEANLRFAQKENMATRIFGRLTAWQNWIFIRPNAVGEKGALKVYGKGDKAAFDFNRV
>NZ_CP044549.1|WP_159596832.1|1241523_1242444_+|helix-turn-helix-domain-containing-protein
MVSSEVKAPMADEEPPRHPFLVALGERVRTLRSRRGMTRKAVAVAADVSERHLANLEYGTGNASILVLLQVAQALHCSLAELIGDVSTSSPEWLLIRELLEKRNETDLRRARIAIGGLLGGSAAAGEDPRRKARIALIGLRGAGKSTLGQRLADDLGFAFIELSREIEKFAGCSINEIHSLYGTPAYRRYERRALEEAIQIYPEVVIATPGGLVSDATNFNLLLSHCTTVWLQADPADHMGRVAAQGDMRPMAASREAMEDLKRILAGRSAFYSKADMAFDTSAYNLEDAFQALRIQVREAIGLDM
>NZ_CP044549.1|WP_159590293.1|1239746_1241324_-|3,4-dehydroadipyl-CoA-semialdehyde-dehydrogenase
MTTSTLLPNFLGGQWQSGTGAGTPLFDPVLGTEIARVSSAGLDLAAGFAFAREKGGKALRALSYGERAGMLAAIVKVLQAHRDAYYEIATANSGTTTKDSAVDIDGGIFTLGYYAKQGEALGSARALLDGERLRMGKDPVFQTQHILQPTHGVALFINAFNFPSWGLWEKAAPALLSGVPVIVKPATATAWLTQRMVKDVIDANILPPGALSVVCGSSAGLMDQLQPFDVVSFTGSAETARIIRSHPAVAERSVRCNIEADSLNSALLDPAATADSEAFTLLVSEVAREMTVKSGQKCTAIRRVFVPRALFDAAAQAIGAKLAKTSVGNPRTETVRMGSLVSQEQKASVIEGIAKLRAEAELLFDGGSAALVDADAKVAACVAPVLLGSREPTKAKVLHEVEVFGPVATLMAYDSIEQAYGLIRRGEGSLVCSVFSADPTFTASAALELGSAHGRVHAISPDVAASQTGHGNVMPMSLHGGPGRAGGGEELGGLRALGFYHRRSAVQASSAALDVLATSAVPFSV
>NZ_CP044549.1|WP_159590291.1|1238133_1239717_-|benzoate-CoA-ligase-family-protein
MNTPHVAAPPERFNFARHLLETNAGRAEKNALIDDQGTLTYGQLADQVLRFSSALTALGLRREERVLLLMHDSSDWVVAFLGALHAGVVPVAVNTLLTAQDYAYMMANSRAQAALVSAALLPTLQTALDKLDAQEGGHEVRHIVASRATGALPNGVHDFAQLVARHDPAQAAANTHGDEPAFWLFSSGSTGAPKGAVHTQANLYWTAELYGKAVLGLRESDVVFSAAKLFFAYGLGNALTFPLSVGASVVLMAERPTPQACFKRFVDQKPTVFYGAPTGYGGMLAAADLPKRNEVALRLCSSAGEALPQDIGQRWTNHFGVEIIDGIGSTEMLHVFLSNRPGDVRYGTTGKPVPGYDIELRGEDGRPVADGEIGDLYIRGPSAALMYWNNRGKSRDTFQGGWTKAGDKYTRDADGYCTYAGRNDDMLKVSGIYVSPFEVEATLVQHPAVLEAAVIGKTDADGLTKTKAFVVLKPEAKATEAELQAFVKEKLAPYKYPRFIEFLPELPKTATGKIQRFRLRERESGAA
>NZ_CP044549.1|WP_159590289.1|1237025_1238018_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MQDTHTPWRRRGFAAFAGLLAFTAITANAQTAYPSRPITMVIGYPPGAIVDTVARQLGTTLTGILGQQVVPENKGGAAGAVGGGTIARAKPDGYTILFTAYTSLQIAAATDRSLNFDPVRDLLPVASVGRPTTLLLVNADFPAKNLDEFVAYVKSRPGKINFGTSGTGSPNHFALEHMNAAYGLKMTPVPYKGAAQMMQDMLGGQVQAIFSSSSLAAGQLQAGNVRALAIGSPDPSPLFPDLPLMAAHGAPGLNASGALGVFAPPGTPTAIVDQLNAAIGKALQDPSIAQKLAGEGLVIKRQTAAQFGKSYRDEAQQIADFIKKSDLTIK
>NZ_CP044549.1|WP_159590287.1|1235168_1237019_+|ATP-binding-cassette-domain-containing-protein
MRRDISSSSPVSALPASAGLAGAPPAPRSDWATLQRLLPYLWQYKGRVVLALAFMVAAKMANVGVPLLLKELVDAMTIQPGSVASMLVVPLGLLLAYGLLRLSTSVFTELRELVFAKATEGATRSISLQVFGHLHALSLRFHLERQTGGMTRDIERGTRGVQSLISYSLYSIFPTLIEVAMVLTLLGTKFDMGYVWITLAALVLYVTFTVTVTEWRTKFRRQMNELESTSQSRAIDSLLNYETVKYFNNEQFEAHRYDAALEKLRRARIKSQTTLSMLNAGQQVVIAVALVLMLWRATQGVVSGELTLGDLVMVNAFMIQLYIPLGFLGVLYREIKQSLTDLEKMFALLEKEREIADVPGAQPLVLAGAPAVKFENVRFSYEPAREILHGISFEIPPGKTVAVVGPSGSGKSTLARLLYRFYDVSNADEGGRITLDGQDVKSVTQASVRQAIGIVPQDTVLFNDTIEYNILYGRPDAGHEAAVQAAKAAHIHAFIERLPLGYQTMVGERGLKLSGGEKQRVAIARTLLKNPPIVIFDEATSALDSANERAIQAELKSAARNKTTLVIAHRLSTVVDAHEILVLVNGEIVERGTHADLVGRGGVYAGMWALQQSGAD
>NZ_CP044549.1|WP_159590285.1|1234696_1235131_-|acyl-CoA-thioesterase
MSPDSSVPAPTSLPTDRELVLKVIPLPGDCNANGDIFGGWVMAQMDLAGAVLPARITRGRQATVAVNQFIFKQPVRVGDILSFFGRVTRVGRTSVTVEVEVYAERFSSQGQYVKVTEATLTYVAIDMEGRPRSIQPPADASATS
>NZ_CP044549.1|WP_159590283.1|1233956_1234700_+|type-1-glutamine-amidotransferase
MASTSSALNAADVLVLQHLFEDGPGFLGQWLDAQGIAWQVRCAEAGDRYPASVRGYRGLAVLGGAWSANDERPTLRQAEGLIREADALGIPVIGHCLGGQLMAKALGGRVERLQQPEVGWWPIAHNGSAMARAWFGDDTMPTVYQWHQDGFTQLPPGAELLASSAACAHQAFALGPHLAMQFHIEITPQKIATWLKEPGDAYAAKVLRHRDSVQDPASMTAATQRYLAGSEALADRIYRRWRSGWPD
>NZ_CP044549.1|WP_159590281.1|1232297_1233818_-|integrin
MNLSLFKRRTRHLAGILLLLLASCGGSPVPQAEMEMAIQYIKSSNTKADDKFGTSTVLSADGNTLAVGSPQPISGEGEVHIFVRSGNTWVQQAHLKASDPDIFDNFGASLALSADGHTMAVGAYGEASSSIFNPGDDSLAQAGAAYVFTRNGTTWTQQTYLKASNIGASDGFGWSVALSADGRTLAVGAPWESSNTTGTTSVPNELADYSGAAYVFTRDPADVWTQQAYVKASNTKPDHGFGISVALSGDGHTLAVGASWEASGFGGNEADTSEPGAGAAYTFTRDHLGTWTQQRYLKASNIGAYEEFGWSLALSADGHTLAVGAYRENGPGDSMPEAGAAYVFAFSAGDWHQQALFRGSYPHTLNHFGIRLALTSDGNTLAVGAVHDNSNAIGFNATPTSNTVVESGAVHVLTREGSTWRQQAYVKASNSRERAELGAVTLSGNGLTWAFGAPSESSNAKGINGNQADTSAPEAGAVYLVDLNPPGSDGSCTPQTFPSCRPPAGW
>NZ_CP044549.1|WP_159590299.1|1245919_1247221_+|benzoyl-CoA-2,3-epoxidase-subunit-BoxA
MNAIAETAVIKQHLIDPEICIRCNTCEAICPVQAITHDNLNYVVDASKCNLCMDCISPCPTGSIDNWRSMPRIRAYSIEEQLKWEELPAELPPEELEGLVDADPEAAVAPTPAAPPAVVKDPSGQETFNSSAFGATLPPWSAAHAYSNIYGPKATQKTVTATVVGNVRVTEVGKTAGSDYDTHHIVLDFGAMPFPVLEGQSIGVVPPGVDDIGRKHHPRQYSIASPRNGERPGYNNLSLTIKRVLQDHDGDPVRGVASNYMCDLQVGDKVEVIGPFGTSFLMPNHPRSNIVMICTGTGSAPMRAMTEWRRRLRASGKFEGGKLMLFFGARTQEELPYFGPLQSLPKDFIDINFAFSRTPGQPKRYVQDAMRERAADLAQLVQDPNTFFYVCGLKSMEEGVVLALRDVVQGAGLNWDTVGGALKREGRLHLETY
>NZ_CP044549.1|WP_159590301.1|1247542_1248175_+|uracil-phosphoribosyltransferase
MSRDVHIIDHPLVQHKLTLMRRKDTSTKSFRELVHELSALLAYEITRDMPMQEIEIETPLEKMTSRVIDGKKVVLASILRAGNGFLDGMLQVIPGARVGHIGLYRDPATLKAVEYYFKMPQGMEERDVIVLDPMLATGNSAVMAVDRLKKTQPRSIRFVCLVTCPEGLKTFHDAHPDVPVYTPAVDRGLNEHGYIVPGLGDAGDRIFGTK
>NZ_CP044549.1|WP_159590303.1|1248355_1250917_+|FtsX-like-permease-family-protein
MNTSPRPLPIRFWNLGWSSLVRDWRAGELRLLMLAVTLAVAALTAVGFFADRLQGGLQRDARALIGGDAVVRSDNAPPDTFGAKARELGLSVVQTLTFPTMGRARDEDGGSARLVALKSVGEGYPLRGALRVADALDAPDAVTREIPAPGTAWVDGALLAALDLKVGQALLLGDSSFTITKLIAAEPDRGGGFMSFAPRVMLNNADLPATGLVQPASRLNYRLAVAGDDGRVGQFTRWAKQAIEQREVRGLRLEALESGQPEMQRTLGRAEQFLNLVALLAALLCAVAVAIAARGFAQRHLDDCAMLRVLGLSQGTMARAYTFEFALTGLIASALGVVIGYAVHHVFVVLLAGLVDASLPAPGVTPVLLGLGMGLTLMMAFGLPPVLQLAQVPPLRVIRRDVGQLKPATLVVLGVGLLGFAVLLMAASRDLLLGGIAVGGFAGAVLLFALASLGAVRLLRASVNENTAPRALVMATRQFTARPAYAVVQISALAVGLLALVLLVLLRTDLISSWRNATPPDVPNRFVINVQPEQSEAFQQALRKAGVERYDWHTMIRGRLVSINGKTVNPDDFEGERAQRLVDREFNLSNMAQVPEHNPIVAGKWTENEADALSVEEGLAEELGLKLGDRMAFDIAGQVSEGRITSLRKVDWGSMRVNFVVVFPVADVPNVPVSYISAFRAPEAANGQTGSNGFDNALVREFPNITNVDMTQTIAQVQRVLGQVIGAVEFLFAFTLAAGLVVLLTAITATRGEREREFAILRAVGAGSGLLQQVQRIELLGVGLLAGFLASVVAVIVGWALARYVFQFAWTASPWVPLAGAIAGAVLALMAGWWGLRSVLRTPVVETLRKAAV
>NZ_CP044549.1|WP_159590305.1|1250926_1251346_+|globin
MNIPLYKPQEPTRHATPFEWIGSEEKVRELVERFYDLMDIEPGYAALRATHGSTLENARQRLFWFLCGWLGGPQHYTEKFGHPMLRARHMPFAIGIQERDQWLACMDQAMGETGVDEALRERLRTSFFQTADWMRNTPR
>NZ_CP044549.1|WP_159590307.1|1251472_1253038_+|AMP-binding-protein
MPHTDSGSKVRFCSVPDLIRDMALKRPHAIALICGGQRITYCELDALAARVAASLQRDGLRRGDTVAVCAAPSIAYVAVFLGAVRVGVVVAPLAATATPESLAAMVHNARASLLFADSSTTAWVRNAGLGDICLVLEPGSASLGTWLVHEGKLPAPVEIAPDWAFNIIYSSGTTGSPKGIVQTHERRVAQVSRRDLLGYGTDSVTLLATPLYSNTTLVALFPTLVAGGTAVLMPKFDARGFLVLAEQERATHTMLVPVQYQRILAEPGFDSFDLTRFRMKLCAGAPFSAAHKREVLRRWPGGLIEMYGTTEGGGSCMLDAQRYPDKLHTVGKPSAGSEFQVIDEQGHVLPQGETGEIVGRATTMMERYHGQAASEAIEWFDAQGRRFLRSGDVGYFDADGFLVLVDRRKDMIISGGFNIYPSDLEQQLRRHPQVQDAAVIGVPSERWGETPVAFVIPRRGSHLDTQEALAWCNAKLGKTQRLADLYLVADFPRNPLGKVLKRELREVYNASTSAPPPGGAT
>NZ_CP044549.1|WP_159590309.1|1253093_1254290_+|lipid-transfer-protein
MSQKTFIAGVGMVPFTKPGASPTYVEMGADAVRRALADAGISYDKIQSAYAGYVYGDSTCGQTVLYEVGRTGIPIFNVNNNCSTGSSALLLARTAVELGQVDCALAVGFEQMQSGALRSHWDDRPQTRTRFHPIWQGLTPDAEGVPRAVRCFAGAGREHMQKYGTKLETFAAIRAKASRHAVNNPLAIFRQELTVEDVMNDKAIWPGVATRLMACPPTCGAAAAIVVSEKFARRHGLRTDVQILAQSMVTDLVESFDPPSMISYVGFHMSRATAQSVYEKSGVDPKDVRVCELHDCFAHNELLTYEAIGLCPEGEAERFVLDGDNTYGGQCVTNPSGGLLSKGHPLGATGLAQCYELTHQLRGTADARQVDNLDIALQHNLGLGGACVVTLYGRADAH
>NZ_CP044549.1|WP_159590311.1|1254329_1255166_+|SDR-family-NAD(P)-dependent-oxidoreductase
MHRTLESKVAIVTGAGRGIGRAVALKLASAGAAVVVNDLDESPALDVVAEIEQAGGRALALAGSVTAPDFGTRTVAATLDAFGAIDIIINNAGYTWDNVIQKMTDEQFEAILTCHLTAPFRLLRAAQPYLRSVSAAEEAQGREVFRKVVNVSSVSGTGGNAGQANYSAAKAGIIGLTKSLAKEWGRMKVNVNCVAFGAIETRLTQRVPQGGEAFVSIEGREIRVGIPADRATAPGREIPLGRLGTPEEAAGSIYLFCLPESDYISGQTIICGGGRGGF
>NZ_CP044549.1|WP_159590313.1|1255202_1256387_+|lipid-transfer-protein
MTAQAYIAGVGMTPFKKPGDNEPYPQMAQAAVRAALADAGLDYSKIQQAYVGYVYADSTAGQRALYEVGMSGVPIVNVNNNCSTGSTALFLARQAVQSGAAECVLALGFEQMKPGPLGSAWPDRPSPFDRFNQTTDELMGAKDLPRVLRYFAGAGRDHMAQYGTKLSTFAKIRAKASRHAANNPLALFRTPLSEDDVLASPSLLEGLMTRLMACPPTCGAAAAIVCSEAFAERHGLRRDVRVVAQSMTTDRPEVFESGDMRELVGFGMAKEAARQVYEQAGIGPQDVDVVELHDCFAQNELLTYESLGLCQEGEAEAFVCDGDNTYGGRVVTNPSGGLLSKGHPLGATGLAQCFELTHQLRGTAEARQVEGARLALQHNLGMGGACVVTLYERV
>NZ_CP044549.1|WP_159590315.1|1256399_1257188_+|SDR-family-oxidoreductase
MNITSTSAVVTGGASGLGAATARLLAARGARVAIFDQDVAGGEKLAADIGGIFCAVDITSQAQVEAAFDKSRAAHGQERILVNCAGIGGPNKTVSRDKDTGEIRPLAVERFERVIQVNLIGTFRAVSLSAAGMFAAPVTDADADGERGVIINTASIAAQDGQMGQVPYSASKAGVAGMTLPLARDFMAEGIRVNTILPGIFDTPMLARAAPHVRAALAASVPFPRRLGDADEYAAVVAMLVTTRYMNGECIRLDGGLRMAPR
>NZ_CP044549.1|WP_159590317.1|1257203_1259948_-|AAA-family-ATPase
MTFRHTNPGAALRPPSPAGTPATTRFVAPRMARGMLPRAALVDRLMDARRKRCISLQGPPGCGKTSLLLTMRGPLMTHGFDVAWLSLVPEDNELDTFLHDLLASLSNVDPASVRTASLLASGGPRDPEAVEHCIIALAHDVADRGGELVLMLDDLHQITSQPVLQALNWLLDYSPPGLHLMLASRDTPPHPLGTAIARLRQLQSAVDFAWPDLQFTPTESEQFLQQRLGLSQEEAMQLHERTGGWIAGLQLLSLHYKEQGTAAREMPLKDAGAFAAYFEQHVLAHLSASDVDLLGLTAICRRFCADLCNALMGGAQTASRIEHRLSRLDRDNLFIVQVQDRDKRVWWRLHPLLREVLQARQEHQPKGHVQQLHRRAWLWFSAHGSVSEAVQHAVLAGESEAAARMVRESVRGLLNQGEFALVKALLRRLPLEVVAQHTGLCLAQAQVHLNSRELDALDASMRALGDAPLNALERAEFDLLRCAALLHRDDADAAVRLLPALQSLPEGADDLLVSTRANLMAWLHLACGEYALAREVLSQHETGHDSPVARLTGLCLEGLSHTLEGRMNEAEHLYRRVLDAGGDGPAGVQVRNLAAALLGDVLYELDELEAACELLDPRMDLIEHAGIPEAILRAAIVLASAHWLCGRRLEALAQLDRLEDYASRHGLARLQTHALCLRLRMQQQRGEMLAVSDALCKLDEVAAQRRGMEDSVSQEIKRLAERAQIAVHLQRGELAPAAEGIRQVLQRLQQAGRLRPVASLLVQLALVERALGHETVAVDTLIEALRLGHRLGLVHTLLDASRRMPAALHGLVESGTLDPVLCFYAQRLLEVAARKRTLRALAEDTATREQPLEPLKERELEILGLLGQALPNKKIARILGLSPETVKWHLKNIYTKLGVTARDAAVARARDLQL

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Crispr_ID: NZ_CP044549_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044549_2

1598455-1598820

Orphan

Consensus_repeat	Method
ACCGCAGGGGGAACCGCA	CRT

6 spacers

The CRISPR arrays of NZ_CP044549_2

>merge|NZ_CP044549|2|1598455-1598820|CRT
ACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAATCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCA

>NZ_CP044549|2|1|1598455-1598820|CRT
ACCGCAGGGGGAACCGCA	GGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGA
ACCGCAGGGGGAACCGCA	GGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGA
ACCGCAGGGGGAACCGCA	GGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGAACCGCAGGGGGA
ACCGCAGGGGGAACCGCA	GGGGGAACCGCAGGGGGA
ACCGCAGGGGGAACCGCA	GGGGGAACCGCAGGGGGAATCGCAGGGGGA
ACCGCAGGGGGAACCGCA	GGGGGAACCGCAGGGGGA
ACCGCAGGGGGAACCGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044549.1\|WP_159590938.1\|1596597_1597656_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371127
NZ_CP044549.1\|WP_159590917.1\|1589304_1590267_-\|SMP-30/gluconolactonase/LRE-family-protein	unknown	unknown	gnl\|CDD\|369882
NZ_CP044549.1\|WP_159590911.1\|1587386_1588355_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP044549.1\|WP_159590926.1\|1591725_1592178_-\|hemerythrin	unknown	unknown	gnl\|CDD\|274154
NZ_CP044549.1\|WP_159590968.1\|1607657_1608788_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|132247
NZ_CP044549.1\|WP_159590962.1\|1605469_1606252_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP044549.1\|WP_159590953.1\|1603621_1604008_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP044549.1\|WP_159590923.1\|1590776_1591736_-\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|99782
NZ_CP044549.1\|WP_159590947.1\|1601035_1602205_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NZ_CP044549.1\|WP_159590944.1\|1600328_1600850_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NZ_CP044549.1\|WP_159590932.1\|1593572_1594628_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP044549.1\|WP_159590965.1\|1606551_1607523_-\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|99782
NZ_CP044549.1\|WP_159590959.1\|1604763_1604973_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225722
NZ_CP044549.1\|WP_159590929.1\|1592183_1593527_-\|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl\|CDD\|239561
NZ_CP044549.1\|WP_159590920.1\|1590256_1590766_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP044549.1\|WP_159590941.1\|1599029_1599479_-\|DUF4440-domain-containing-protein	unknown	unknown	gnl\|CDD\|379209
NZ_CP044549.1\|WP_159590950.1\|1602677_1603529_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367137
NZ_CP044549.1\|WP_159590914.1\|1588372_1589308_-\|SMP-30/gluconolactonase/LRE-family-protein	unknown	unknown	gnl\|CDD\|369882
NZ_CP044549.1\|WP_159590935.1\|1594789_1594960_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044549.1\|WP_159590956.1\|1604035_1604620_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270296

Protein	Function_ID	Function_description	E-value
NZ_CP044549.1\|WP_159590938.1\|1596597_1597656_+\|hypothetical-protein	gnl\|CDD\|371127	pfam10546, P63C, P63C domain. This domain was identified by Iyer and colleagues.	8.41829e-18
NZ_CP044549.1\|WP_159590917.1\|1589304_1590267_-\|SMP-30/gluconolactonase/LRE-family-protein	gnl\|CDD\|369882	pfam08450, SGL, SMP-30/Gluconolaconase/LRE-like region. This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyze diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.	6.53003e-48
NZ_CP044549.1\|WP_159590911.1\|1587386_1588355_-\|hypothetical-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	1.10021e-103
NZ_CP044549.1\|WP_159590926.1\|1591725_1592178_-\|hemerythrin	gnl\|CDD\|274154	TIGR02481, hemeryth_dom, hemerythrin-like metal-binding domain. This model describes both members of the hemerythrin (TIGR00058) family of marine invertebrates and a broader collection of bacterial and archaeal homologs. Many of the latter group are multidomain proteins with signal-transducing domains such as the GGDEF diguanylate cyclase domain (TIGR00254, pfam00990) and methyl-accepting chemotaxis protein signaling domain (pfam00015). Most hemerythrins are oxygen-carriers with a bound non-heme iron, but at least one example is a cadmium-binding protein, apparently with a role in sequestering toxic metals rather than in binding oxygen. Patterns of conserved residues suggest that all prokaryotic instances of this domain bind iron or another heavy metal, but the exact function is unknown. Not surprisingly, the prokaryote with the most instances of this domain is Magnetococcus sp. MC-1, a magnetotactic bacterium.	9.27282e-14
NZ_CP044549.1\|WP_159590968.1\|1607657_1608788_-\|hypothetical-protein	gnl\|CDD\|132247	TIGR03203, pimD_small, pimeloyl-CoA dehydrogenase, small subunit. Members of this protein family are the PimD proteins of species such as Rhodopseudomonas palustris, Bradyrhizobium japonicum. The pimFABCDE operon encodes proteins for the metabolism of straight chain dicarboxylates of seven to fourteen carbons. Especially relevant is pimeloyl-CoA, basis of the gene symbol, as it is a catabolite of benzoyl-CoA degradation, which occurs in Rhodopseudomonas palustris.	4.44593e-86
NZ_CP044549.1\|WP_159590962.1\|1605469_1606252_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	2.25964e-88
NZ_CP044549.1\|WP_159590953.1\|1603621_1604008_+\|hypothetical-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	3.91141e-32
NZ_CP044549.1\|WP_159590923.1\|1590776_1591736_-\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	gnl\|CDD\|99782	cd06185, PDR_like, Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur [2Fe-2S] cluster domain. Although structurally homologous to FNR, PDR binds FMN rather than FAD in it's FNR-like domain. Electron transfer between pyrimidines and iron-sulfur clusters (Rieske center [2Fe-2S]) or heme groups is mediated by flavins in respiration, photosynthesis, and oxygenase systems. Type I dioxygenase systems, including the hydroxylate phthalate system, have 2 components, a monomeric reductase consisting of a flavin and a 2Fe-2S center and a multimeric oxygenase. In contrast to other Rieske dioxygenases the ferredoxin like domain is C-, not N-terminal.	1.75048e-85
NZ_CP044549.1\|WP_159590947.1\|1601035_1602205_-\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.23221e-18
NZ_CP044549.1\|WP_159590950.1\|1602677_1603529_+\|hypothetical-protein	gnl\|CDD\|367137	pfam02668, TauD, Taurine catabolism dioxygenase TauD, TfdA family. This family consists of taurine catabolism dioxygenases of the TauD, TfdA family. TauD from E. coli is a alpha-ketoglutarate-dependent taurine dioxygenase. This enzyme catalyzes the oxygenolytic release of sulfite from taurine. TfdA from Burkholderia sp. is a 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase. TfdA from Alcaligenes eutrophus JMP134 is a 2,4-dichlorophenoxyacetate monooxygenase. Also included are gamma-Butyrobetaine hydroxylase enzymes EC:1.14.11.1.	4.03887e-50
NZ_CP044549.1\|WP_159590932.1\|1593572_1594628_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	1.43146e-103
NZ_CP044549.1\|WP_159590965.1\|1606551_1607523_-\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	gnl\|CDD\|99782	cd06185, PDR_like, Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur [2Fe-2S] cluster domain. Although structurally homologous to FNR, PDR binds FMN rather than FAD in it's FNR-like domain. Electron transfer between pyrimidines and iron-sulfur clusters (Rieske center [2Fe-2S]) or heme groups is mediated by flavins in respiration, photosynthesis, and oxygenase systems. Type I dioxygenase systems, including the hydroxylate phthalate system, have 2 components, a monomeric reductase consisting of a flavin and a 2Fe-2S center and a multimeric oxygenase. In contrast to other Rieske dioxygenases the ferredoxin like domain is C-, not N-terminal.	1.16824e-111
NZ_CP044549.1\|WP_159590959.1\|1604763_1604973_+\|hypothetical-protein	gnl\|CDD\|225722	COG3181, COG3181, Uncharacterized protein conserved in bacteria [Function unknown].	4.9904e-08
NZ_CP044549.1\|WP_159590929.1\|1592183_1593527_-\|Rieske-2Fe-2S-domain-containing-protein	gnl\|CDD\|239561	cd03479, Rieske_RO_Alpha_PhDO_like, Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3,4-dioxygenase (CBDO), phenoxybenzoate dioxygenase (POB-dioxygenase) and 3-nitrobenzoate oxygenase (MnbA). ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to tolerate and utilize aromatic compounds for growth. The oxygenase alpha subunit contains an N-terminal Rieske domain with an [2Fe-2S] cluster and a C-terminal catalytic domain with a mononuclear Fe(II) binding site. The Rieske [2Fe-2S] cluster accepts electrons from a reductase or ferredoxin component and transfers them to the mononuclear iron for catalysis. PhDO and CBDO are two-component RO systems, containing oxygenase and reductase components. PhDO catalyzes the dihydroxylation of phthalate to form the 4,5-dihydro-cis-dihydrodiol of phthalate (DHD). CBDO, together with CbaC dehydrogenase, converts the environmental pollutant 3CBA to protocatechuate (PCA) and 5-Cl-PCA, which are then metabolized by the chromosomal PCA meta (extradiol) ring fission pathway. POB-dioxygenase catalyzes the initial catabolic step in the angular dioxygenation of phenoxybenzoate, converting mono- and dichlorinated phenoxybenzoates to protocatechuate and chlorophenols. These phenoxybenzoates are metabolic products formed during the degradation of pyrethroid insecticides.	6.66142e-76
NZ_CP044549.1\|WP_159590920.1\|1590256_1590766_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	6.20468e-14
NZ_CP044549.1\|WP_159590941.1\|1599029_1599479_-\|DUF4440-domain-containing-protein	gnl\|CDD\|379209	pfam13474, SnoaL_3, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	1.92764e-15
NZ_CP044549.1\|WP_159590914.1\|1588372_1589308_-\|SMP-30/gluconolactonase/LRE-family-protein	gnl\|CDD\|369882	pfam08450, SGL, SMP-30/Gluconolaconase/LRE-like region. This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyze diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.	2.62687e-43
NZ_CP044549.1\|WP_159590944.1\|1600328_1600850_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	3.7352e-06
NZ_CP044549.1\|WP_159590956.1\|1604035_1604620_+\|hypothetical-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	1.31258e-73

>NZ_CP044549.1|WP_159590938.1|1596597_1597656_+|hypothetical-protein
MTNESEEPTGKAKGGHARAAKLTKEQRSEIARKGAMARKAKVLDADGPGQDNIAHEGTLKLGDFTVPCFVTGSGERLIASRKMQEILKVVEDDPDDQPGVQRPGTRFRRFLTRKFFNSLISQEELQDLFTPVRRLYKGRVIVGFKADSLTKFCKLMMQAKDKDLLTTERQSIVAMQARVLYDSFAKIGLVALIDEATGYQQIRDPSALRMLVQQYIAAEKREWDKQFPDSFYDGLNRIYNSKKMTTTAKGAVIQNRPQHFANFTRTYVYEPLENGAVLEELDRINPKMNAKGTRRDRFHQHLSQGYGIEKLKRQVLAVETIIDVSDNVGQFKRLYSKKFGTPKGGQLDLLED
>NZ_CP044549.1|WP_159590935.1|1594789_1594960_+|hypothetical-protein
MDVPRTQTYTRYYLAERVGGTPSAMGWESQCVMLVPQDKLASLNLREPDRVVVSAL
>NZ_CP044549.1|WP_159590932.1|1593572_1594628_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MNEKASNGCYSNRKGPSTVTMKESQIMMKINRRKAMIAAAAAAVSQPSLAQALSWPARPVTFVVPYPAGGQMDVVARLLARNVEQIIKQPVLVDNRAGANTLIATNYVARSPADGYTFLINSSVLVSNPVVMSTAKYNAFTDFIPVARKYDWSVAWVVPPKSAQSLELFIAQARASSKPLTFGSPGHGSASHFYAEMFAKAAGIKITHVPYKGEAPIVADLLEARLDAAMVTVGLAQELSKDGRVRALAASGTRRPKSMPNLPTFGELGVPGLTAESYVGLFAPAQTPKAIVNRLNAAVNAVSASADFQKQMFANALEIAPPLTPEQFAAVVRKSSDEWMNIKSQTGIQID
>NZ_CP044549.1|WP_159590929.1|1592183_1593527_-|Rieske-2Fe-2S-domain-containing-protein
MTTSPALERLRNDNHDLTHTGPGTVMGDLMRSYWIPAMKSSELESGGSPVRLLLLGEKLVAFRSPSGEVGVMDHRCPHRTASLFFARNEEGGLRCIYHGWKFNVEGACIDAPNIPEQEHVKEKVHTVAYQVHEANGLVWVYMGSAEVAPPTPKFEIMNIDEGELSIEFAQRDCNWLQALEGDIDTSHLAFLHVGNVNEEDLHENDPMRHVVRDRTVHLEVDDAPWGTTYCSVRTADDGKTHLRYANFLFPCWTQAPQGPFESNIFLRAWVPMDDTHMMLITVAWKKRVGLIPMKNGSPLPGVAPHELLPNTSDWLGRFRAVQNKENDYMIDREAQRTNEIWCGMKDIVTQDVAVTESMGDIADRTREHLVHSDLMIVRTRRRLLRAARDLAATGTKPPGVQDPFVYSDARSGEMVVPDYKHWTDTYQQKLKEAIRVSAAKVAQSELG
>NZ_CP044549.1|WP_159590926.1|1591725_1592178_-|hemerythrin
METSLLSETVWSELLLTGHAAIDATHRAFALVIHELQQANPASAAASIAAARAHCEDHFAEEEEPMRRHGHSGADCHAVEHAAVLQSVREVCAMDVQDVATVHRLGIALAEWLEAHTIYLDSALSQWIVRRRYGGAPVAIRKPAALQNAC
>NZ_CP044549.1|WP_159590923.1|1590776_1591736_-|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein
MRAELPLIEARVVAIRQEAEGVLSFELERSDAGPLPPFAPGAHIDLVLPTATRSYSLCNESDGKRYVVAVATSSTSRGGSRFIHEQLRVGARIDISAPRNNFNLDGSAAHSVFIAGGIGITPILSMIRKLAAAGRSWELHFRCKGRSTAPFLGTLEQLAAQSKGLINLSLSERDDTRMSMEALVRAGRPGSHFYCCGPHAMLADFEAATQDAPPTSVHTEYFSAAERSATDGGFMVTLARSGKSFEVRAGQTILETLTSQGVEVPSSCREGVCGVCETRVVDGIPDHRDHVLSRAEHAANSSMMICCSGSLTDELVLDL
>NZ_CP044549.1|WP_159590920.1|1590256_1590766_-|MarR-family-transcriptional-regulator
MSTSKKKTSNVEEETQQVSVFIDRSQYVPHLLNILNNRISSGASDLYIKRFGVGINDWRVLSIVARYPGCIATFAAEKMEVHKAIVSRAMQVLVDHGYVRLEPQGKEKLVFLTPQGKRLYEKIAKVALAREKLLLRGLSEERKAQLRTLLAHLTANVPAMNEHFARDDK
>NZ_CP044549.1|WP_159590917.1|1589304_1590267_-|SMP-30/gluconolactonase/LRE-family-protein
MTSSALQHAPLRVEVICEGLSFPEGPVWLPDGSVLVVEIRSGNLTRISKAGEKSTVAYVGGGPNGLAIGPDGAYYICNNGGFEWHDHPDGRQTPGLQAQGYISGSIQRVDPQTGEVRVLYDKCGPHALRGPNDIVFDAHGAFWFTDLGKRRDRSMDHGGVYYAWPDGSKIVEVIYPMNTPNGIGLSPGGDRLYVAETSPGRLWAFDIAGPGSVHQAVTDRPHGGELLAGLPGFQLFDSLAVQDSGHICVATLFNGGITVVSPDGQSIEHVPLPDPFTTNICFGGAELREAFVTLSSTGQLVRVTWPRPGLRLNADRKACQ
>NZ_CP044549.1|WP_159590914.1|1588372_1589308_-|SMP-30/gluconolactonase/LRE-family-protein
MINEAVEFAVELRFPEGPVVMQDGSVIVVEIAAGCVIRCWPDGRVTTIAVVGGGPNGAALGPDGKLYVCNNGGMAWHRDPDGGLYPHGRAENYTGGSIQRVSIENGTVETLYRDVGGTALSAPNDIVFDESGGFWFTDLGEISGTHIARGGVCYARCDGTCIRQVVFPMLTPNGIALSPDGKSLYVAETLTARLWRFEVVAPGELALRSWPAISPGDLLYVAPEYCNFDSIAVEANGNICVATLGIGGITVVSPSGQRVEFVAYPDRATTNLCFGGADMRSAYVTQSRTGRLLMQSWAREGLAPAFGRQPR
>NZ_CP044549.1|WP_159590911.1|1587386_1588355_-|hypothetical-protein
MSFSRRAVLRAASLTPLYTLALHAGAQQFPARPIKLVVPYPPGGTFDAISRLLADKLSVGLGQPVIVENKPGANGMIALSSVAKSTPDGYTLVVTGTSLVLNFASFKTVSYRLDEFTAVGGLVDMPLAIGVNPAFPAKTFQELVAAIHAAPDKYSISTSGTIEEIILAELRKTANLKFQTIPYPGAAPSLNAVVGGIVPIIITAAGAAQQLHNAGKVRLLAITGGQRLSALPGVPTIAELGIPIKDMSSWCGVLAPAKTPDAVVRRLSDEVQKAMQSPEVGTRIAALSMAVNARDAAQFSRFTEYEASKWKQAAAEAGIKPE
>NZ_CP044549.1|WP_159590941.1|1599029_1599479_-|DUF4440-domain-containing-protein
MPKSDQSNDRDAVLASFAAYVNAIRSKDATAAIHCFDGEAVTFDFAPPLENRFDALKDPKGLEEWFKTWTGPIQTDVGDTTVTVSGDLAVLHGLQRLHGSNTDGDVDMWYRATVVMARKNTGWRITHIHNSVPMAMDGSGKALTDLKPE
>NZ_CP044549.1|WP_159590944.1|1600328_1600850_+|helix-turn-helix-domain-containing-protein
MTPSAIHSIQRDVQRLGIKLSEARRRRRMSQRAMADQTGMSLSTVRRLERGEPGVAIHALLSGFKVLEILDACIGLLSLGEDDVDQGRAAELLPKRVRQPKAGRDISAPMRRGSFDVGSPAPAAEFGAGVAQPTEAISLQPQLPVDEPKKQGRVAVVKPRQSHSQGQIDLFSL
>NZ_CP044549.1|WP_159590947.1|1601035_1602205_-|MFS-transporter
MKWTPELVRLLAGFMCLHAAMSALRMAAPLLALRMGYGTAEIGGMLALFALAQIFMALPAARFIDRRGLRLTLLCCAVGACASIGLSAARPSFSALCVSAFVSGGAVGVSLMAIQGHVLRVASDVMERKHSIAWLAIAPAISQFLGPMITGVIIDGHGFRVALLVLAIAPIGMGLCALAVRTDLSPRRPDQEARRSTWSLWRISGFRRVLLLNWLMTASWDLCIFMVPVMGYERGLSASSTAMVLGLFSCAALVSRLLVPYISRYVQEWVFISGALMTAGALLAIYPLTSGVFGMGLCSFGIGLLLGGVQPSVMILLHEVTPIHRQTDAMGMRLLMVNASAVAVPVVYGAVVGFVTIGGAVLVTGALVTLGGCVALSSTRAVGSSTPNK
>NZ_CP044549.1|WP_159590950.1|1602677_1603529_+|hypothetical-protein
MKLSFEPLFPLFGVRVSGFDPTVPMDADTSEKLRNALRDHRLLLIRGYELSEDDQVRLSTVAGSLTYRNSGNYTDPDKRSSLVSNAHDDGMFGSGELSFHSDLSFTEHILKARSLNALLLPPPTELGGETLYADVETAYDDLDEGIKRRVEGLRARFAATYERADGTEVVEFVRPLIGTHPETGRRFIAASRAVTKEVEGMERSEFRPLLKQLWEHMEQPKYIYRHRWELNDCLFWDNIGLQHARTPFDPNLKRALRAVSIDESSVAASYAAAVNKVSAQAGA
>NZ_CP044549.1|WP_159590953.1|1603621_1604008_+|hypothetical-protein
MATLSTIAKLLLAALMAPWIAAGSLHAQENYPTKHIQFISPMTAGGPGDALSRAVATSLSARLHVPVIVQNVPGAGSAIGTGTLARSAPDGYTLGLSTAGTFSINPFLYSKLPYNEEKDFAPISPLVS
>NZ_CP044549.1|WP_159590956.1|1604035_1604620_+|hypothetical-protein
MQADNLAQLLAFAKANPNKVTLGSGGVGTTAHLAMEAIKHLSNAPILHVPYKSGAPAMTDLLGGNVSCMIDALGTSLPRVQNGSLKSLAVTGAKRGPLLPKVPTVAESGLPGFEEFSGKYWMGIMAPAGTPQPILDKLNAVVQEILRDDAALRQRLDALGLDPLPMSASQFSGFLKVDRDSWGRIVKMTGAKAD
>NZ_CP044549.1|WP_159590959.1|1604763_1604973_+|hypothetical-protein
MNATDKRAMVRNTLRTLANAVAVTAALVTGAAAQSYPSKRLTIIVPYAPGGQFDFVGRKLAQLLSSTDL
>NZ_CP044549.1|WP_159590962.1|1605469_1606252_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MVVENRASVTGNVGVGAGVRAPADGYTVTMISNQNIVANLAEAQPTFSIAKDLEPVTLLAEYYTALLVKSSLPVTNMAELIALIKSQPGKITLGSGGIGSSGHVAMGLLTQKTGAEVLHVPYKGEGPLIAALLGGEVDMAFITLSGAVAQLKTGRVKGLGITSAKRVAALPDMPTIAETVPGFFHAAWLGMSVPIGTPRDHIAFLSKELTAILQTADVHQTLTSRSYEIIGSTPEQFRQKIQSETEVLGKLAKQLNLKNE
>NZ_CP044549.1|WP_159590965.1|1606551_1607523_-|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein
MNTFQNEINVRVASIALVAVDICMFELVAEDGASLPPFSAGSHVDVTVDGTTRQYSLCNDPSENHRYQIAVLKDSAGRGGSVKMHERVKAGDTIRISAPRNHFHLASGAQQHLLLAGGIGVTPILCMAERLASIDSEFEMHYCARSPERAAFVPRVQQSGFADKVRFHFDNGPEEDKLDIPALLKTPKAGTHVYVCGPKGFMNAVLDTARENGWPEDQLHYEFFASDAAAPREDDGSFQVKLASSGRVIPVRAEQTVTEALAEAGVDVGTSCMQGICGTCITRVLEGTPDHRDMYFSPEEQAANDQFTPCCSRSLTPLLVLDL
>NZ_CP044549.1|WP_159590968.1|1607657_1608788_-|hypothetical-protein
MQFRLNELQQQLENSVQRFAQDHQGIESWRSAAREQGAFREETWARMAEMGWLGAALPEQFGGMELGARETAIIMEGVGSALLLEPYWSTAVFGARILMAAATLQQQQQWLPDIADGSLRLAVALTEPGAGHDWTHPGCEARQDGEGWRISGKKIAVLDGAVAQRLLVLARTEDADHAIFCINAHAEGVERHDAISLDERHCSDYVFSNVRAADGERLNADVLVFPAIQQAMDHAMVALAAESVGAMSAVLRSTVEYLKTRKQFGKPLSEFQALRHRVADMLMATEQTRSLVLMAANTLDAGSPHASRLAEAAKIQAGQAGRFVGENAVQLHGGIGVTDELLVGHYFKRLLCIDLLLGDSAWHLQRFSATDPQLSE

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Crispr_ID: NZ_CP044549_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044549_3

3712353-3712496

Orphan

Consensus_repeat	Method
CTCTCTGGCGCGCCTTCGGCGCTTGGAGGGGGGACGACACCTTGGGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044549_3

>merge|NZ_CP044549|3|3712353-3712496|CRISPRCasFinder
CTCTCTGGCGCGCCTTCGGCGCTTGGAGGGGGGACGACACCTTGGGCCGTCGTGCATGGGGAGCCCCCCCCCTGCGCTGCTCCGCAGCTTCCCCCCTCTCTGACGCGCCTTCGGCGCTTGGAGGGGGGACGACACCTTGGGCCG

>NZ_CP044549|3|2|3712353-3712496|CRISPRCasFinder
CTCTCTGGCGCGCCTTCGGCGCTTGGAGGGGGGACGACACCTTGGGCCG	TCGTGCATGGGGAGCCCCCCCCCTGCGCTGCTCCGCAGCTTCCCCC
CTCTCTGACGCGCCTTCGGCGCTTGGAGGGGGGACGACACCTTGGGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044549.1\|WP_159594610.1\|3710073_3710700_+\|flavin-reductase-family-protein	unknown	unknown	gnl\|CDD\|224766
NZ_CP044549.1\|WP_159594614.1\|3715153_3716953_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|270234
NZ_CP044549.1\|WP_159594612.1\|3711465_3712320_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380366
NZ_CP044549.1\|WP_159594606.1\|3706494_3707367_+\|fumarate-hydratase	unknown	unknown	gnl\|CDD\|377546
NZ_CP044549.1\|WP_159594618.1\|3720312_3720954_-\|3-oxoacid-CoA-transferase-subunit-B	unknown	unknown	gnl\|CDD\|188219
NZ_CP044549.1\|WP_159594615.1\|3716963_3717971_-\|2-dehydropantoate-2-reductase	unknown	unknown	gnl\|CDD\|235821
NZ_CP044549.1\|WP_159594604.1\|3703965_3704166_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044549.1\|WP_159594616.1\|3718254_3719022_-\|DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182100
NZ_CP044549.1\|WP_159594621.1\|3723223_3725656_-\|endopeptidase-La	unknown	unknown	gnl\|CDD\|223542
NZ_CP044549.1\|WP_159594609.1\|3709098_3710049_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|368185
NZ_CP044549.1\|WP_159594611.1\|3710723_3711443_+\|aldolase	unknown	unknown	gnl\|CDD\|226356
NZ_CP044549.1\|WP_159594605.1\|3704457_3705051_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044549.1\|WP_159596983.1\|3712628_3713603_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270297
NZ_CP044549.1\|WP_159594617.1\|3719060_3720269_-\|3-oxoadipyl-CoA-thiolase	unknown	unknown	gnl\|CDD\|181624
NZ_CP044549.1\|WP_159594607.1\|3707377_3707998_+\|fumarate-hydratase	unknown	unknown	gnl\|CDD\|180366
NZ_CP044549.1\|WP_159594613.1\|3713602_3715078_-\|aromatic-amino-acid-lyase	unknown	unknown	gnl\|CDD\|376303
NZ_CP044549.1\|WP_159594608.1\|3708062_3709049_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP044549.1\|WP_159594619.1\|3720968_3721670_-\|3-oxoacid-CoA-transferase-subunit-A	unknown	unknown	gnl\|CDD\|131482
NZ_CP044549.1\|WP_159596982.1\|3705052_3705865_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271177
NZ_CP044549.1\|WP_159594620.1\|3721772_3722579_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|131484

Protein	Function_ID	Function_description	E-value
NZ_CP044549.1\|WP_159594610.1\|3710073_3710700_+\|flavin-reductase-family-protein	gnl\|CDD\|224766	COG1853, COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only].	4.0898e-35
NZ_CP044549.1\|WP_159594614.1\|3715153_3716953_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	8.29531e-57
NZ_CP044549.1\|WP_159594612.1\|3711465_3712320_+\|hypothetical-protein	gnl\|CDD\|380366	cd02238, cupin_KdgF, pectin degradation protein KdgF and related proteins, cupin domain. This family includes bacterial and archaeal pectin degradation protein KdgF that catalyzes the linearization of unsaturated uronates from both pectin and alginate, which are polysaccharides found in the cell walls of plants and brown algae, respectively, and represent an important source of carbon. These polysaccharides, mostly consisting of chains of uronates, can be metabolized by bacteria through a pathway of enzymatic steps to the key metabolite 2-keto-3-deoxygluconate (KDG). Pectin degradation is used by many plant-pathogenic bacteria during infection, and also, pectin and alginate can both represent abundant sources of carbohydrate for the production of biofuels. These proteins belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.	1.84672e-07
NZ_CP044549.1\|WP_159594606.1\|3706494_3707367_+\|fumarate-hydratase	gnl\|CDD\|377546	pfam05681, Fumerase, Fumarate hydratase (Fumerase). This family consists of several bacterial fumarate hydratase proteins FumA and FumB. Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth. Three fumarases, FumA, FumB, and FumC, have been reported in E. coli. fumA and fumB genes are homologous and encode products of identical sizes which form thermolabile dimers of Mr 120,000. FumA and FumB are class I enzymes and are members of the iron-dependent hydrolases, which include aconitase and malate hydratase. The active FumA contains a 4Fe-4S centre, and it can be inactivated upon oxidation to give a 3Fe-4S centre.	6.30287e-74
NZ_CP044549.1\|WP_159594618.1\|3720312_3720954_-\|3-oxoacid-CoA-transferase-subunit-B	gnl\|CDD\|188219	TIGR02428, 3-oxoadipate_CoA-transferase_subunit_B, 3-oxoacid CoA-transferase, B subunit. Various members of this family are characterized as the B subunits of succinyl-CoA:3-ketoacid-CoA transferase (EC 2.8.3.5), beta-ketoadipate:succinyl-CoA transferase (EC 2.8.3.6), acetyl-CoA:acetoacetate CoA transferase (EC 2.8.3.8), and butyrate-acetoacetate CoA-transferase (EC 2.8.3.9). This represents a very distinct clade with strong sequence conservation within the larger family defined by pfam01144. The A subunit represents a different clade in pfam01144.	2.67343e-105
NZ_CP044549.1\|WP_159594615.1\|3716963_3717971_-\|2-dehydropantoate-2-reductase	gnl\|CDD\|235821	PRK06522, PRK06522, 2-dehydropantoate 2-reductase; Reviewed.	2.31347e-85
NZ_CP044549.1\|WP_159594616.1\|3718254_3719022_-\|DNA-binding-transcriptional-regulator	gnl\|CDD\|182100	PRK09834, PRK09834, DNA-binding transcriptional regulator.	3.49164e-88
NZ_CP044549.1\|WP_159594621.1\|3723223_3725656_-\|endopeptidase-La	gnl\|CDD\|223542	COG0466, Lon, ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP044549.1\|WP_159594609.1\|3709098_3710049_+\|amidohydrolase-family-protein	gnl\|CDD\|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	1.19113e-21
NZ_CP044549.1\|WP_159594611.1\|3710723_3711443_+\|aldolase	gnl\|CDD\|226356	COG3836, HpcH, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism].	6.54487e-49
NZ_CP044549.1\|WP_159596983.1\|3712628_3713603_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270297	cd13579, PBP2_Bug_NagM, Uncharacterized NagM-like protein of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	1.24205e-110
NZ_CP044549.1\|WP_159594617.1\|3719060_3720269_-\|3-oxoadipyl-CoA-thiolase	gnl\|CDD\|181624	PRK09050, PRK09050, beta-ketoadipyl CoA thiolase; Validated.	0
NZ_CP044549.1\|WP_159594607.1\|3707377_3707998_+\|fumarate-hydratase	gnl\|CDD\|180366	PRK06043, PRK06043, fumarate hydratase; Provisional.	5.34063e-34
NZ_CP044549.1\|WP_159594613.1\|3713602_3715078_-\|aromatic-amino-acid-lyase	gnl\|CDD\|376303	pfam00221, Lyase_aromatic, Aromatic amino acid lyase. This family includes proteins with phenylalanine ammonia-lyase, EC:4.3.1.24, histidine ammonia-lyase, EC:4.3.1.3, and tyrosine aminomutase, EC:5.4.3.6, activities.	1.24859e-96
NZ_CP044549.1\|WP_159594608.1\|3708062_3709049_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	1.55368e-114
NZ_CP044549.1\|WP_159594619.1\|3720968_3721670_-\|3-oxoacid-CoA-transferase-subunit-A	gnl\|CDD\|131482	TIGR02429, 3-oxoadipate_CoA-transferase_subunit_A, 3-oxoacid CoA-transferase, A subunit. Various members of this family are characterized as the A subunits of succinyl-CoA:3-ketoacid-CoA transferase (EC 2.8.3.5), beta-ketoadipate:succinyl-CoA transferase (EC 2.8.3.6), acetyl-CoA:acetoacetate CoA transferase (EC 2.8.3.8), and butyrate-acetoacetate CoA-transferase (EC 2.8.3.9). This represents a very distinct clade with strong sequence conservation within the larger family defined by pfam01144. The B subunit represents a different clade in pfam01144, described by TIGR02428. The two are found in general as tandem genes and occasionally as a fusion.	6.73424e-127
NZ_CP044549.1\|WP_159596982.1\|3705052_3705865_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271177	cd00796, INT_Rci_Hp1_C, Shufflon-specific DNA recombinase Rci and Bacteriophage Hp1_like integrase, C-terminal catalytic domain. Rci protein is a tyrosine recombinase specifically involved in Shufflon type of DNA rearrangement in bacteria. The shufflon of plasmid R64 consists of four invertible DNA segments which are separated and flanked by seven 19-bp repeat sequences. RCI recombinase facilitates the site-specific recombination between any inverted repeats results in an inversion of the DNA segment(s) either independently or in groups. HP1 integrase promotes site-specific recombination of the HP1 genome into that of Haemophilus influenza. Bacteriophage Hp1_like integrases are tyrosine based site specific recombinases. They belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	5.41079e-40
NZ_CP044549.1\|WP_159594620.1\|3721772_3722579_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|131484	TIGR02431, p-hydroxybenzoate_hydroxylase_transcriptional, beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family. Member of this family are IclR-type transcriptional regulators with similar DNA binding sites, able to bind at least three different metabolites related to protocatechuate metabolism. Beta-ketoadipate is the inducer for PcaR, p-hydroxybenzoate for PobR, and protocatechuate for PcaU. [Regulatory functions, DNA interactions].	8.0683e-107

>NZ_CP044549.1|WP_159594612.1|3711465_3712320_+|hypothetical-protein
MSLLPSQLATYARHHEQTPRAVPGDSAPAWITRGANFVVVVSRVQTGDTLQRDNLDEYVLLVPDTAGLSLQVQAGAESLQAGPDSLTIVPPGPSTLRVQGAGLVVRIFSSDVSDLAALADNQATYATPNPDAAPLVAWPEPVGGYKLRHYRLADYVAEGSQMRIFRTRKLMVNPLLKRPVARDVRKLSPHSHTDFEQGSLALSGTYVHHLRYPWGPDMTLWQEDQAEEMGSPSLLVVPPKVVHTSRNIDAPGVLVDIFAPPRWDFSKKGVVCNGDEYPMPAEQE
>NZ_CP044549.1|WP_159594611.1|3710723_3711443_+|aldolase
MTQAYQLGTFVKTASPHIIEVLGTTKLDFVCIDAEHAPFDRATLDLMVLATRATHLKAFIRIAEVNPAVILSALDIGAAGILVPHVDSADDARNVVAMARYKGGARGYSSSPRFAGYGSLGMKEALRIGDEAQVICQIESDAAVKDAEAIAAVPGVGGLFVGRADLALSMGLDNPREPRVLEATRHVLAVARKAGIRAGMFVAGNAERDEFAALGADWFIVSSDQTLLRQGAQAIAHAA
>NZ_CP044549.1|WP_159594610.1|3710073_3710700_+|flavin-reductase-family-protein
MSATGFTTLDATTMDTATAYRLLVGAVVPRPVAWITTRGKDGVVNAAPFSSYNYVAHSPPMVAVNIGTKDGQLKDTARNIVETGEFVVNVATLDTMDLMHGCSADYPSETSEIEALGIELLPGERIAVPRVAASPIQMECRLERALTLGRGLNTLYIGEVLLFHLSSTVFDGRYVDSVKMRPISRLGGPLYAELGELHNRPQLQKPPK
>NZ_CP044549.1|WP_159594609.1|3709098_3710049_+|amidohydrolase-family-protein
MPMSASARPLLFDAHAHLVADDQTAYPRKPMQRAANAPPRMPGVIGTPGGHHGPNPINEVPDVARMLEWMKEENVDGAVAVQKRMIYRYDNSYILDSSDKHPEIFSAVVILDAEDAGTAPLVRQYIQNHGLAGVRLFGGREPDGSMPWLNSPMALKTWEVANEFGLVMNLEVLSVGGGGPSVPALIELTKQYPNVNIAIDHLLEPEMEKSGHYGLDENFEALVPWKNISFKWTSINLDICREEGIPADKVLRRAIDLYGADRLMWGSDIGTSSGTYKDMVQRALDSAVLLNDDEKRALFHDTGRRIFQKGGSGRRA
>NZ_CP044549.1|WP_159594608.1|3708062_3709049_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MKRRTFQTAVAAACLAAGFAASAPALAQTGGWPNKPVRLVVPFPAGGSTDVVARFIAQGLSDKFGQSFVVDNRGGAGGNIGTDAVAKAAPDGYTIGLSTSGPLVNNKFLYKNMPFDSDKDLAPIALVCEIPLVIASTPKVSAKNLKEFIQQAKAKPDAYTVGQPGNGTIGHLALEQLSMVTNTKLSTVAYRGDTPLMTDLLGANIQGLSAPITAFIPNLASGKLNGLAVTSATRFPGLPNIPTAKEQGIDMVATVWFAVVGPAGTPPEVIKALNTEINNIVSSTYGKAKLQTYGAVVNVGAPDLLRKMINEDSKKWQKVISTANVKLD
>NZ_CP044549.1|WP_159594607.1|3707377_3707998_+|fumarate-hydratase
MSRLHELTLPLSEERVRDLRVGDMVTLTGAVTVSIGIPTHKRMAEAVRKGEALPVDLNGGAFFHLSTYVREQDGISVPLYLNPSTSTRYNAWMPDIVRGLGLRLVGGKGGLDDASVAALRECGCAYLSFLGGGLPLLSRALRGVRSSHWNEYISQFRLLTLDVAALGPCTVAIDAHGASIYDNLRERAQGRMPDILDRLRRARQAT
>NZ_CP044549.1|WP_159594606.1|3706494_3707367_+|fumarate-hydratase
MPISSATIRAVTASLYERSLKKIPDDTRAVLGKASERETDATARRTFTMMLESADSAARNGQLVCSDVGIPTYSVKIGTRVQFEGPVRQAMVDGLADMAANIDPPILKMVTHPLTHERSYAGKDIPIVSFDVIDDADYVDMVCAPKAMGTGRWEAVEAFVYPTVEDVEKYVLDVILRAGSQPCLPIVVGVGIGGTFDQATRLAKEAVLRPHGKPQPDPLLAGMEQRLLDAINQMGFGAMGTGGDCSAMAVNIDYSASHGFVPVAVCLNCWINRRTAARIHGDGRVEMLYE
>NZ_CP044549.1|WP_159596982.1|3705052_3705865_-|tyrosine-type-recombinase/integrase
MRIGEISRKDINAAKAKLQNKAAYRSVPGGSIATTAKVTPATVNRYLASLSSVLNYAMEHEIIDAHPMKGGKVKKLTEGTGRTRILTAKEEGELLEQADRSTWPMLGLFVRMCLTTAARRSEVLNLRWKDVNFDESVAILGKTKNGKARALPLVTSVRAALSEAQKVKPLKSDFVFFNPRDPSKVFNPDAAWKQCRIDAGLWADRDDPLDRVVLHTTRHTSVTKMLRGGANLAQAAVVSGHQTLAMLKRYEHLAAADAVAIAEQHLEGKG
>NZ_CP044549.1|WP_159594605.1|3704457_3705051_-|hypothetical-protein
MVAKKKSAPKASKSAKKPLTVVVHGEHGSYIQRNRPRWPLVLSTKGVIAYGVASRNSDEGRAHARFFEILNLACVDPLLIKSPALITLANILRDAISASEPGEPIEDILAPVEMLIASMRSREGGGGRPLAEVAWMEWKRRLEYKQKHRPTLSKRECYEDIAAEWVEEGRAKKLIWTGVRDGISDLKKLNSLKKKPG
>NZ_CP044549.1|WP_159594604.1|3703965_3704166_-|hypothetical-protein
MSLDDLITIEQLVEAYPRILTVPTLRWQLRHRDTNGLGHACVRVGKKLLIHRPSYERWLPTRGGAI
>NZ_CP044549.1|WP_159596983.1|3712628_3713603_-|ABC-transporter-substrate-binding-protein
MQRRHFNTRLAALAAASVSSLPVLAQDGAPMRILVGFSPGGSVDAVARLLAERLKEPLGMNVIVENKPGATGRVALGEVQRARPDGRTLVLAAGGAMVIFPWLYPGTLGYNPVKDFSPVSRVTSLGFVISVGPAAPVTDLKGLIAWAKANPGKAMYATSGAGSVPHFSGLLLAQTLGLQLTHVAYKGGPQAEQELIGGHVPMMIDSPTSTTIDLHRTGKLRIVAVTGKTRLPALPDVPTLQEAGVNLAIDNFFGLYGPAGMPVDTVNRIDRAVGQVLAQPDVREKIQAAGLVTDHGGPQELASVQAAQLKRWEAPIKASGFKVE
>NZ_CP044549.1|WP_159594613.1|3713602_3715078_-|aromatic-amino-acid-lyase
MVTLPQIELDGQTLSARDVVQIARHGAAVALAPAALARMEASRAVVERIVASGELVYGVTSSVATKTGTPLDPRRYGEFNRRLLETHDMGMGPLASREMVRAMLVVMLNNMASGRLGVRPVLANLLVDALNTQREFKVHLWGSTGESDMAAVANIALDLYAGTELAAGETIALINSSPVSIGLAALAMADLGNILASWPLAAALSMEGYGANPSPVSDVAVRSRPFKGLQRAAQAIAAQLHGSHLMSAGGPRHLQDPLAFRSLPITLGNAFDSHDFAAGQFAIELNASQNNPVVSIEEQRLVSVANFDLLALSMALDTLRLGIAPLVTSSTERVAKLVDSFWSGLDSGLLAQDDVGLPGFNGMAQVHKGITAEARLLAAPVVTELPSSSHSNGNLDRVSMASLAARRTLELAQLCKSILAVELVVAAQAVDLRQPPRLGAGTSKLHGFVRGLVPHAGGAQRVPHPAPVLEALERLDWQLDSIPPTTTGDAR
>NZ_CP044549.1|WP_159594614.1|3715153_3716953_+|LysR-family-transcriptional-regulator
MTIASQYVSLRQLRVLLSVGETGSFSATANAIGLTQSAVSQSLRTLEEALEIPLVDRTTRQVVLSDAGRRLVGPLREALDHLERVLSQAKTEASATRGVVRLACSQSVGGDFLPGRITAMQRAWPDIRLQLREQPHADVLEGVMRGTAELGLVVGDGLPSELSGTALLTEPYFVYCSLQHPFARRSYVSAASLRYEKLVLLDASAGGRFQLDRFLHTHDVATAEAQEVTQVAMAMALVSGQVGVAVLPGGDHATLARADGPGVKAIPLTPGFERTVSLVTRRNTALSPVVERAAGALVDPNGGTSTSSRQRTTLVVPFHSSGPADRFGRSFAVALAKVMGQPVDVENVIGLGGVLGVHRVTRSVADGCTIGLAGTGATVFDRLLNQDELFDVFSDITCLSGLVRIPNVLLVGKHVAASTLAELIAQVRLRPDGFTTAAIARGPLAVLPELFQKRTETRMLSRHYDGLVPAMVDLVRGRLDVLFAEVGGSVMDAIRSHAVQPLMIAGHDRAHGLPDVPTAPECGLPDVVADGGYCVVAPASFPASRQKALQAQIHAALRSPAIVEGFLSQGGTPDLRTGAEYIAYVRHEQERWAALLGKA
>NZ_CP044549.1|WP_159594615.1|3716963_3717971_-|2-dehydropantoate-2-reductase
MNSVSTSHPRRIGIVGAGAVGGHVAARLALAGHQVTLLARGATLEAVRAHGLRYATGGQASQRVEVRAEATPQAMGAQDLVILALKSQALPTVVPTLGPMLAADTPVLTLNNGLPWWYFLVPGQALEGQRLARVDPLGETERAVDISRVLGGTIMTSCHCPEPGVVVHSAGARLALGEPGGGLSERAALWSGVLADAGLGAVASPQIRVDIWLKLLGNICANPLSLLTGVTTDRMIDDPGVRSLFAAMMEECIALGRRLGLTLDTTTEQRMAQTRQLGAIRSSMLQDLEAGRSVELDAILGAPIECAQAVGQPVPRLQEVFALACLRAEGAGLYP
>NZ_CP044549.1|WP_159594616.1|3718254_3719022_-|DNA-binding-transcriptional-regulator
MASFAPIRSVERALDVLLALNRGPISTLDQLYQQTRIPKPTLVRLLETLQKRGMVARAPQYGAYSLSSGVKMLSAGYHGEPRIVEAAAAPANALTRKIKWPLAVAVPDYDAVVVRYSTIPDSPLSLLHSTINMRLSLVGRAMGRAYLAFCGREERRALLDILNLSSSEEDASAKDRPAMLATLKKIRQQGYALRAPGIRPVSGTLAVPVMEGQRVVATLGMTWIASAVSNEQAVERYLEPLQGLSRLISTRLVNL
>NZ_CP044549.1|WP_159594617.1|3719060_3720269_-|3-oxoadipyl-CoA-thiolase
MTQRQAFICDAIRTPFGRYGGALSSVRTDNLGAVPLKALMARNPGVDWAAITDVIYGCANQAGEDNRNVARMAALLAGLPMDVPGATINRLCGSGLDALGTAARAIKSGEATLMIAGGVESMSRAPFVMPKAESAFSRNNAVYDTTIGWRFVNPLMKAQYGVDAMPETAENVATDFKIEREAQDRMAMASQLKAVAAQKAGHLAAEITPVTIPQKKGDAIVVDKDEHPRETSLEALAKLKGVVRPDGTVTAGNASGVNDGACALLLADEATAAKHGLTPKARVVGMATAGLAPRIMGMGPAPATRKVLELTGLSLAQMDVIELNEAFAAQGLAVLRDLGLKDDDARVNQWGGAIALGHPLGASGARLATTATSQLHRIGGRYALCTMCIGVGQGIAVILEKV
>NZ_CP044549.1|WP_159594618.1|3720312_3720954_-|3-oxoacid-CoA-transferase-subunit-B
MTYTRRTKVELAQRVARDIHDGAYVNLGIGQPTLVANHLPPGIEVVLHSENGILGMGPAPAAGEEDYDLINAGKQPVTLLPGGSFFHHADSFGMMRGGHIDICVLGAFQVSATGDLANWSTGEPDAIPAVGGAMDLAVGARQTWVMMDLLTKQGQSKLVQQCSYPLTGVACVKRVYSDLATLECTPQGLRLIDTVDGLDRAELERLIGLPVAA
>NZ_CP044549.1|WP_159594619.1|3720968_3721670_-|3-oxoacid-CoA-transferase-subunit-A
MINKLADSIETALADTADGATVLIGGFGTSGIPNELIDGLIAHGARDLTVVNNNAGNGDTGLAALLKAGRVRKVICSFPRQVDSHVFDGLYRSGALELELVPQGNLAERLRAAGAGIGGFFTPTGYGTELAKGKETRIIDGKGYVFETPIHGDLALIKAERGDRWGNLTYRKAARNFGPVMAMAARKTVATVHEIAELGELDPEIVITPGIHVSQVVRIERTVTRAGGFKAAA
>NZ_CP044549.1|WP_159594620.1|3721772_3722579_+|helix-turn-helix-domain-containing-protein
MPSSSKAAPPRPGDTYVQSFARGLQVVRSFSANAPEQTLSEVAERSGLTRAGARRILLTLQTLGYVEGDGKWFRLTPRILELGFAYLSSMPIWDLAEPVVQALVDRVSESSSIAVLDGADIVYVMRVPTQKIMKISLGIGSRLPAFCTSLGRVLLAQLDDEDILRRLEESPRTALTRHTVTDTTTLLKRIHQVRRQGWSVVDQELEEGLISVAAPIQGADGRVNAAINLSGQANRTNARAVQEQLLPPLLEAAQAITQLLQRKTRMGR
>NZ_CP044549.1|WP_159594621.1|3723223_3725656_-|endopeptidase-La
MSGQTPLPSTSIELPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMESERRIMLVAQKAAAKDEPSTEDMFEMGCVATILQMLKLPDGTVKVLVEGLQRAKVLDIRDGESHFVANVTPVDPVAEQSNLQVNELEALRRAVMQQFDQYVKLNKKIPSEILTSISSIDDAGRLADTIAAHLPLKLESKQVVLDLDQINKRLENLFEQLEREVDILNVDKKIRGRVKRQMEKNQRDFYLNEQVKAIQKELGEGEEGADIEEIEKKIKLAKMPAEARKKADAEFKKLKLMSPMSAEATVVRNYIDALVGLPWSKKTKIKHDLAHAEAVLNEDHYGLEKVKDRILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSVAKATGRKYVRMALGGMRDEAEIRGHRRTYIGAMPGKVLQSLNKVGTRNPLFLLDEIDKLGTDFRGDPSSALLEVLDPEQNHTFGDHYIEVDFDLSDVMFVATSNSMNIPPALLDRMEVIRLSGYTEEEKTNIAIRYLLPKQLKNNGIREGELTVENDAVRDIVRYYTREAGVRSLERELSKICRKVVKGLLLKKYTPTVVVNTENLSEFLGVRKYSYGRAEATNQVGQVVGLAWTEVGGDLLTIEVAIMPGKGVITRTGSLGDVMKESVEAARTVVRSRARVLGIKDEQFDKRDIHIHVPDGATPKDGPSAGAAMTTALVSAITGIPVRADVAMTGEITLRGEVTAIGGLKEKLLAALRGGIKTVIIPEENVKDLAEIPDNVKQGLEIVPVKWIDKVLAIALERQPVPLTEEEVAAQIAAASVSKPAAASDAVKH

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Crispr_ID: NZ_CP044549_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044549_4

4387735-4387830

Orphan

Consensus_repeat	Method
CCATCCAGAGGCATCGAGGGACGGCTGCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044549_4

>merge|NZ_CP044549|4|4387735-4387830|CRISPRCasFinder
CCATCCAGAGGCATCGAGGGACGGCTGCGCCACCGAAATGCCCCGCTCTCTCCGGCGGGCATGCCCCATCCAGAGGCATCGAGGGACGGCTGCGCC

>NZ_CP044549|4|3|4387735-4387830|CRISPRCasFinder
CCATCCAGAGGCATCGAGGGACGGCTGCGCC	ACCGAAATGCCCCGCTCTCTCCGGCGGGCATGCC
CCATCCAGAGGCATCGAGGGACGGCTGCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044549.1\|WP_159595157.1\|4380186_4380816_+\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	unknown	unknown	gnl\|CDD\|235534
NZ_CP044549.1\|WP_159595174.1\|4399164_4399980_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235852
NZ_CP044549.1\|WP_159595165.1\|4386889_4387729_+\|undecaprenyl-diphosphate-phosphatase	unknown	unknown	gnl\|CDD\|237134
NZ_CP044549.1\|WP_159595159.1\|4381493_4381787_-\|YfhL-family-4Fe-4S-dicluster-ferredoxin	unknown	unknown	gnl\|CDD\|224066
NZ_CP044549.1\|WP_159595168.1\|4390777_4391485_-\|two-component-system-response-regulator-CreB	unknown	unknown	gnl\|CDD\|236838
NZ_CP044549.1\|WP_159595166.1\|4387911_4389225_-\|cell-envelope-integrity-protein-CreD	unknown	unknown	gnl\|CDD\|236960
NZ_CP044549.1\|WP_159595160.1\|4381799_4382318_-\|pantetheine-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|234674
NZ_CP044549.1\|WP_159595156.1\|4379122_4380097_+\|ribose-phosphate-diphosphokinase	unknown	unknown	gnl\|CDD\|234929
NZ_CP044549.1\|WP_159595175.1\|4400183_4401155_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP044549.1\|WP_159595162.1\|4382993_4384352_-\|insulinase-family-protein	unknown	unknown	gnl\|CDD\|223685
NZ_CP044549.1\|WP_159595169.1\|4391625_4393944_+\|PBP1A-family-penicillin-binding-protein	unknown	unknown	gnl\|CDD\|227342
NZ_CP044549.1\|WP_159595167.1\|4389319_4390759_-\|two-component-system-sensor-histidine-kinase-CreC	unknown	unknown	gnl\|CDD\|236846
NZ_CP044549.1\|WP_159595161.1\|4382354_4382969_-\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	unknown	unknown	gnl\|CDD\|223813
NZ_CP044549.1\|WP_159595164.1\|4385837_4386893_+\|signal-recognition-particle-docking-protein-FtsY	unknown	unknown	gnl\|CDD\|236686
NZ_CP044549.1\|WP_159595173.1\|4397990_4399136_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173847
NZ_CP044549.1\|WP_159595163.1\|4384365_4385796_-\|insulinase-family-protein	unknown	unknown	gnl\|CDD\|223685
NZ_CP044549.1\|WP_159595172.1\|4396889_4397990_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293811
NZ_CP044549.1\|WP_159595158.1\|4380885_4381539_+\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|235457
NZ_CP044549.1\|WP_159595170.1\|4393954_4394680_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NZ_CP044549.1\|WP_159595171.1\|4394719_4396849_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223972

Protein	Function_ID	Function_description	E-value
NZ_CP044549.1\|WP_159595157.1\|4380186_4380816_+\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	gnl\|CDD\|235534	PRK05618, PRK05618, 50S ribosomal protein L25/general stress protein Ctc; Reviewed.	1.29417e-71
NZ_CP044549.1\|WP_159595174.1\|4399164_4399980_-\|hypothetical-protein	gnl\|CDD\|235852	PRK06688, PRK06688, enoyl-CoA hydratase; Provisional.	2.09247e-74
NZ_CP044549.1\|WP_159595165.1\|4386889_4387729_+\|undecaprenyl-diphosphate-phosphatase	gnl\|CDD\|237134	PRK12554, PRK12554, undecaprenyl pyrophosphate phosphatase; Reviewed.	2.25377e-124
NZ_CP044549.1\|WP_159595159.1\|4381493_4381787_-\|YfhL-family-4Fe-4S-dicluster-ferredoxin	gnl\|CDD\|224066	COG1143, NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion].	1.66733e-08
NZ_CP044549.1\|WP_159595168.1\|4390777_4391485_-\|two-component-system-response-regulator-CreB	gnl\|CDD\|236838	PRK11083, PRK11083, DNA-binding response regulator CreB; Provisional.	2.98327e-113
NZ_CP044549.1\|WP_159595166.1\|4387911_4389225_-\|cell-envelope-integrity-protein-CreD	gnl\|CDD\|236960	PRK11715, PRK11715, cell envelope integrity protein CreD.	2.112e-177
NZ_CP044549.1\|WP_159595160.1\|4381799_4382318_-\|pantetheine-phosphate-adenylyltransferase	gnl\|CDD\|234674	PRK00168, coaD, phosphopantetheine adenylyltransferase; Provisional.	9.02822e-81
NZ_CP044549.1\|WP_159595156.1\|4379122_4380097_+\|ribose-phosphate-diphosphokinase	gnl\|CDD\|234929	PRK01259, PRK01259, ribose-phosphate diphosphokinase.	0
NZ_CP044549.1\|WP_159595175.1\|4400183_4401155_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	1.58213e-112
NZ_CP044549.1\|WP_159595162.1\|4382993_4384352_-\|insulinase-family-protein	gnl\|CDD\|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	7.9621e-66
NZ_CP044549.1\|WP_159595169.1\|4391625_4393944_+\|PBP1A-family-penicillin-binding-protein	gnl\|CDD\|227342	COG5009, MrcA, Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane].	0
NZ_CP044549.1\|WP_159595167.1\|4389319_4390759_-\|two-component-system-sensor-histidine-kinase-CreC	gnl\|CDD\|236846	PRK11100, PRK11100, sensory histidine kinase CreC; Provisional.	0
NZ_CP044549.1\|WP_159595161.1\|4382354_4382969_-\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	gnl\|CDD\|223813	COG0742, COG0742, N6-adenine-specific methylase [DNA replication, recombination, and repair].	8.4031e-54
NZ_CP044549.1\|WP_159595164.1\|4385837_4386893_+\|signal-recognition-particle-docking-protein-FtsY	gnl\|CDD\|236686	PRK10416, PRK10416, signal recognition particle-docking protein FtsY; Provisional.	2.5678e-172
NZ_CP044549.1\|WP_159595173.1\|4397990_4399136_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	3.97255e-120
NZ_CP044549.1\|WP_159595163.1\|4384365_4385796_-\|insulinase-family-protein	gnl\|CDD\|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	1.28301e-99
NZ_CP044549.1\|WP_159595172.1\|4396889_4397990_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293811	cd07725, TTHA1429-like_MBL-fold, uncharacterized Thermus thermophilus TTHA1429 and related proteins; MBL-fold metallo hydrolase domain. Includes the MBL-fold metallo hydrolase domain of uncharacterized Thermus thermophilus TTHA1429 and related proteins. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	1.89387e-22
NZ_CP044549.1\|WP_159595158.1\|4380885_4381539_+\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|235457	PRK05426, PRK05426, peptidyl-tRNA hydrolase; Provisional.	6.6397e-109
NZ_CP044549.1\|WP_159595170.1\|4393954_4394680_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	5.15627e-25
NZ_CP044549.1\|WP_159595171.1\|4394719_4396849_-\|hypothetical-protein	gnl\|CDD\|223972	COG1042, COG1042, Acyl-CoA synthetase (NDP forming) [Energy production and conversion].	9.60486e-108

>NZ_CP044549.1|WP_159595165.1|4386889_4387729_+|undecaprenyl-diphosphate-phosphatase
MNTTTLWLEAAFLGLIQGLTEFLPVSSSAHLRIIGPLLPSGGDPGAAFTAITQIGTEAAVLLYFRHDIVRIFLAWWASLTQPAKRQDPDARMGWLIIIGSVPIVVLGLLFKDAIEHSLRNLYITATMLIVFAVILGLADRFGRRERPLSQLTWGHGLLFGLAQAMALIPGVSRSGGTITAGLMMGYTREAAARYSFLLAIPAVMGSGFYQLLRSIQHGSPIAPGPTALATLIAFGVGYGVIVVFLKLVSTRSYMVFVVYRILLGLLVFGLLGGGVLSAL
>NZ_CP044549.1|WP_159595164.1|4385837_4386893_+|signal-recognition-particle-docking-protein-FtsY
MFSFFRKKPPAPPAEPAPDLTEPPAPVPEAPTPPTVAAPVAMAVAVAVAAPPERKGWLDKLKSGLRKTGSSIATVFTGTQIDEALYEELEAALLMADTGVKATTDLLVDLKRRVKENKTTDPKAVKGLLADAITDLLAPLQKPLVIGEHKPTVVMVAGVNGAGKTTSIGKLTRHLADEGATVLLAAADTFRAAAREQLAVWADRNTVEIITQQGGDPAAVSFDAVTAGKARGRDVVLVDTAGRLPTQLHLMEELRKIKRVVQKAEASAPHEVLLVIDGNTGQNALNQVKAFDDALQLTGLIITKLDGTAKGGVLCAIAREKPVPVYFIGVGEKLEDLETFDAREFAQALLS
>NZ_CP044549.1|WP_159595163.1|4384365_4385796_-|insulinase-family-protein
MPLISTRLPALLMALCLLAPGAWGQSSPPAKDNQPHSFILRNGMTLIVQPDRRAPTAVQMLWVRVGSMDEVDGTTGVAHALEHMMFKGTPDVPPGEFSRRVAAIGGIDNAFTMRDATAYHTQVPVRRLEAVMQLEADRFARNQWADDEFKREIEVVKEERRQRTEESPRARMFEALNAMVFQASPYRRPNVGWMSDLDAMTPEDLRAFYQRWYVPANAALVIAGDVDVEQTRALAEKHFGSIPARAVPARKPREEPPQAGPRRLEYRAVADQALIALAYKVPQWRGAEVDNDTDRDALALTVLSAVLDGYDGARLDRALVQGGASGQRIADSAGSSYGLMGRGPQLFMLTGVPAAGVTTEAVETALKAEISRIAREGISEAELRRVKTQWTAGEIYKLDSLAYQARELGSYWIQGLGLDTGDRLIARLRAVTAAQVQSVAQRYFTDDQLTTGVLVPDPSRREAAPAAGQRPALTRH
>NZ_CP044549.1|WP_159595162.1|4382993_4384352_-|insulinase-family-protein
MLNLFALLKPLARPALLAWPLAAVMATAAHATIPIERWTHASGARVHLVTSPSIPMLDVQIDFDGGRRRETADRAGLAGVTAGLLSGGVAARNGQPALDENQLSEAWADLGAQFGAQSTLDRFSLSLRSLTEPDLLERAVALAARQLAAPAWPEHVWQRDRERLLAALKEAENRPGTHASRAFSKAVYGAHPYGLRPEASTYKAISVADMRAFYRRHAAACRAQVSMVGAIDRAQADRIVDQLMAAVKDHGCSALPALPLVQPLKQAVDERLPFAAAQAQVLIGQPGVPRTDPDFLALFVGNYVLGGGGFVSRLMNEVREKRGLTYGVSSYFVTGRQAGSFQISLTTRPDQAAQAVDVVREVVRGFVAQGPTEAELQAAKDFLINGEALRLDSNRKLLDNVANIAWNDLPLDYLETWTQQVERLRVEDIRRAFARVLQPERMVTVVVGAKQP
>NZ_CP044549.1|WP_159595161.1|4382354_4382969_-|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD
MKKPTPKVPRTAANAPHEVRIIGGLWKRTKLPVADKSGLRPTPSRVRETVFNWLGQDLSGWRCIDAFAGTGALGLEAASRGATEVVLVEQDSALLANLGRITTQLKASGVRVERGDGVAALRQRSGQGVDAVFLDPPFGDGQNEALYMAALAAARQAVRRDGWIYLEAPRTWSEDELAQMGLQIHRQGKAGAVAFHLLRPLPAQ
>NZ_CP044549.1|WP_159595160.1|4381799_4382318_-|pantetheine-phosphate-adenylyltransferase
MSSALASTGGNGRVAVYSGTFDPITLGHEDVARRASQLFEDVIIAVAIAHHKKTRFTLQERLDMAAVAASRMPGRVRVLPFDGLIMDFCRQHNATAVVRGIRNLTDFDYEAQMAAMNRKLNPAVETVFLLPQADLQCISSTLVREISQLGGDISQMVSASVAQNLKPRPVQA
>NZ_CP044549.1|WP_159595159.1|4381493_4381787_-|YfhL-family-4Fe-4S-dicluster-ferredoxin
MALLITDECINCDVCEPECPNQAIHMGEAFYEIDPSRCTECVGHFDEPQCVQVCPVECIPVDPNHIESRETLWQKYQRLQSAGQPLSSADGAEPPAA
>NZ_CP044549.1|WP_159595158.1|4380885_4381539_+|aminoacyl-tRNA-hydrolase
MIRLIAGLGNPGPEYEHTRHNAGFWWVDEAARLLKVSLQMERAHFGLVARANVAGQSVWLVEPQTYMNLSGKAVGSIARFFKIAPEEMLVVHDELDLPPGEVKLKKGGGHAGHNGLRDIHAQLGSPDYWRLRVGIGHPGNKNEVANWVLKKPSPDDRIAIAQALDRSLKALPNLIAGEMDKATALIHTSKLPRPKPPRPAADPQAAGGSAPSADDKG
>NZ_CP044549.1|WP_159595157.1|4380186_4380816_+|50S-ribosomal-protein-L25/general-stress-protein-Ctc
MQFVAFERAKQGTGASRRLRNTGRAPGIVFGGEKPADTIELDHNALWHALKKEAFHSSILDMELAGKVHKVLLRDVQYHPYKPQVLHVDFQRVDEKTRLRKKVPLHFVNAENSPAVKTDKCVISHVLNDIEIECLATQLPEFIEVDLGEVVKGATVHTGDIKLAKGVKLVTHGRKNITVATVVEPVEEVVAAPVAAAPADDKKGKKGKK
>NZ_CP044549.1|WP_159595156.1|4379122_4380097_+|ribose-phosphate-diphosphokinase
MQVQPPDFMIFTGNANPVLASEIAQHLGTQLGAANVGRFSDGEVTVEITQNVRARHVFVIQSTCAPTNENLMELLIMVDALKRASAERISAVIPYFGYARQDRRPRSARVPISAKVVANLLQTVGVSRVLTMDLHADQIQGFFDIPVDNIYASPVLLGDLRQKNYPDVLIVSPDVGGVVRARALAKQLNCDMAIIDKRRPKANVSEVMHVIGDIEGRNCVIMDDMIDTAGTLVKAAEVLKERGAKNVYAYCTHPIFSGPAIERIAKGSALDEVVVTNTIPLSQAAQACTKIRQLSVAPLMAETIARIASGESVMSLFADQDNLF
>NZ_CP044549.1|WP_159595166.1|4387911_4389225_-|cell-envelope-integrity-protein-CreD
MNKYPLLSKVMVIGLLMLLLSIPLLMVRGAIEERSMNREAATQDVARAHAGEQTLTGPVLYVPYTETFLRKVVLDGGQTREELVTQSHVAIRFPSVMETRSRLQTETRWRGVFPVKVFTSVNESTGQFVWSDVEPKEKNSQITLGQPSLLLGVSDLRGLLNAPQLKVEGRAIAVAPARAAQRLPLPLVAPLNLAQLRAGAVLPFSLQLELAGTGRIGWVPLADENRVHLQSSWPHPSFGGDFLPRTRSVSAQGFEASWSVPSLSTQAQRQFAQTGERPETPESFSVSLDDPVDVYRLTDRATKYGAMFILLTFAAFFVLEMVKRWRIHPMQYLMIGAALVLFFLLLLSIAEHLGFLPAYLSASAACIGLLAHYLRHVLGGWKPGLLMSGLLVALYGVLYGILMSEDNALMMGSLLLFGVLASIMVATRKVDWYSVMK
>NZ_CP044549.1|WP_159595167.1|4389319_4390759_-|two-component-system-sensor-histidine-kinase-CreC
MRIGLRLLLGFFLVLGLALFVVLRVLLDEVKPGTRLAMEDSLVDAAYTLALLATPDMKAGAIANGSFAQSLQGLNDAQPGANISGFRKDGVDYRIVVADAQGIVRYDSRHEAVGQDFSRWNDVARTLRGEYGARSSPASPYAPDSTVMHVAAPIRDGDRVIGVLSVSRPNARLEPYIQRSETRILRWSWVLLGLSLGIGVLFSWWIASSLSRLRGYANAVARGERVPLPVLGRMSGSTEFSELAQALERMRVQLEDKAYVERYVHTLTHELKSPLAAIRGASELLQEEMPAQDRQRFAGNIQRQAERLHQLVDKLLNLAHVEQMQGLVTREPVNLSALTRELLQRLEPRLRLKSLRVRDALGEGQTVQGDPFLIGQALQNLLDNAIDFSPPHGELEVGLRRDGAWLEWSVRDQGSGIPDYARERIFERFYSLPRGEGQDKGSGLGLCLVQEVSQLHGGELRVENVSESRGCLARWRLPA
>NZ_CP044549.1|WP_159595168.1|4390777_4391485_-|two-component-system-response-regulator-CreB
MRKRILLLEDEQAIADTLLYALQSEGFEVRHVALARQALEAFQDNPPDLAILDVGLPDGNGFEVCRTMRRTSELPIVFLTARSEEIDRVLGLELGADDYVVKPFSPREVCARVRAILRRSAAAMSTAPFPVLTTAAEASDGLILDEAAQRFRVGNALLPLTRYEYLLLATLMRRPERIFSRTELMDLVWGDAPHTADRTVDAHVKLLRAKLREHGVKTEVIQTHRHMGYSLRLAG
>NZ_CP044549.1|WP_159595169.1|4391625_4393944_+|PBP1A-family-penicillin-binding-protein
MLQKPILRRTALALAVTAAVVVALPVPASTFDMPSLERIVHYQPKLPLQVFTADGVEIAQFGTERREYMPISRIPKQMQQAVLAVEDARFREHSGVDPKGMARAVVAAITGGRRQGASTITQQLVRTMLLTHQFSAERKAKEIWLALKLEDEISKDRILEIYMNEIFLGQRAYGFAAASQIYFGKPLDKLSLAETAMLAGLPQNPYYANPVANFERATQRQRVVLDRMRATEAINDQQLATARAEKLVIRAPGSRSVHAAHVAEMARLAVVERFGTEAYSSGIRVTTSLRAADQRAAHNAVQKGVLALDRRGAWRGPEDLETLPSDNGAELERAAAEALKDHRDDEDLRVGIVLSASPKAVQVQLASGERVTVQGAGLQWVQRALDAKAKTPVKIVRGSIVRVVTTGKTKDKKSDVWAISQWPEIEAAMVSLDPQTGRVRALVGGFDFAKQPFNHVTQGWRQPGSALKPLLYSAALEARVMPATLVDDLPFTAANGWSPTNSNGQYEGPITLRHALMKSSNLASVRVLQHTGTRAARDWTARFGLDPARQPDDLSLALGTGSVTPLQMAQAYATVANGGWQVAPVVIEKITDAQGKVLFEAPPAAPLSEESRAIPARNAFVLGSLLNDVTRSGTAARAQALLKRPDIYGKTGTTNDAVDAWFAGYQPSLAAAVWVGYDKPRSLGGGESGGRIALPIWIDYMGAALKGVPVAQTPAPPDGLVREGDDWLYAEWRDGGWVSAISDSAGVQYQTNVGAEIGKVFNSFGAWLRGER
>NZ_CP044549.1|WP_159595170.1|4393954_4394680_-|GntR-family-transcriptional-regulator
MGKPIYVELAETLQQQIASGQYPVGSTLPPEVMLCEIHGVSRFTARAALAALQRQGYVTRRPRIGSVVQAKNPQRSYLVQTDSAGDVLRFSSISELHHVSTEDVVADAALAADLGCEVGEPWIKVATYRDSPETKQAASWTDFYLRPEHRSLVPLIGHKRGSVWQFMNELQQRPIECIEQTVEACKIPKAVAEVLGVPPKSPALRAIYRLYSDGDEGRFYVAIGLYPEGRFRLTHTMRRDR
>NZ_CP044549.1|WP_159595171.1|4394719_4396849_-|hypothetical-protein
MNTFTDHAMLASAAGRLSSLFHPRSIAFIGASERPNTPASRGLRNCLRHGFAGGLYPINPKYPTLFGVRCYASLAELPEVPELVMIALSAEMSLNAVADCKAAGVKAVVVCSAGWEEQGPEGVERAERLKALLADTPMRMLGPNCLGAGNPAAGLCLGYNSSFESMAHARTGRVGLVTQSGAMMGGLLLNGEDAGADVGLYAHVGNAMDIGMEETVEYMLDDPQIDVVALMVEGLRQPQRFVQAARRAQALGKPLVVFKAGASELGQQAVMSHTGALAGSDAIFSTVCREHGVLRVQESEDLLPSAAMLAQWKHKRPVGQGGLLVFTLSGGAASILADECADAGVPLPALSATTLARLEAILPSYVKASNPLDVGGAVFSDPELPRHALAIALEDDAVDAVLWVGVGAPRDERSQLWLNQALDVLGQSDKPGMVIPVSGYVQEPGFERARGLGLPVARSLRAAARMIGQARAVQQPVLPAGMAGEGMPPLPAPGGLVDEVQSKALLKALGLRVPESRVVRAVSEVAAAAQQLSGAVVVKGMARSIAHKSEHGLVALNLGTPQAAEAAAQAMCQRAPELDFQGFLVEQMAPRGVEVALGIQRDPAFGPMLMFGLGGVAVELFKDVAFGACPLSPERARALIGMTRAAALLRGFRGQPPADEDALVEAMVRLSQFAAHHAGRLAEMDINPVIVLPQGQGVIALDAIMACDA
>NZ_CP044549.1|WP_159595172.1|4396889_4397990_-|MBL-fold-metallo-hydrolase
MQPLHDAPSPTRPTPSPIGPWLWTRRDALPPLRYHAARIEIGVPHEIAEGVFLLRLPLPFALKHINVYLLPEADGWSVVDTGIDTEASRAVWERVFQHPRFAGRTLRRIVVTHHHPDHIGLAGWLAERCGAPVLMTRGELEVAGRYADPARDVVAERTPLWNEHGLPADVAQGLYRHMPRYGVQVCALPAQVADIDPTRPLALGERWWTPVIGQGHSPDHLSLLRDDGQVLIGGDQVLPEITPNIAVWPGGDQNPLRSYLASLQRFEGFDASTLLLPSHRQPAYGIATRVDEIRAHHEERLLTLLQACERPMTGYEFLPTLFGRALRHEEIGFGLGEAIAHLNFLEDEGLLASSLDSHGCRRFMRT
>NZ_CP044549.1|WP_159595173.1|4397990_4399136_-|acyl-CoA-dehydrogenase
MDFGFTPDQQLFRESVRRFMAKECTREYIRACSDNDRFPHELYANMARQGWMGIPFPEQYGGAGLGPMELAIFLEEAGYGWYGAGTAYFTTVVLGAYNILTYGTEAQKQEFLPKVIAGETKLAFALSEPNVGSDAAAVELFAQEQGDHFVLNGQKMFTTNAHVANQIVVVTRTLRKPEKKHHGITIFLVDADAPGIEIRPLKQMGRSATHTNEVFFRDVKVPRTRMMGQLHEGWANLNSGLGMERLSVAMMYAGTSQAMIDYVMNYAKQRRQFGQSISKFQAVQHKLADMQIKTDVARLLGYRVAWMLEQGLPCFKEMSMAKLWASEAMFEIANHGVQIMGGYGVLKEYDMELFFRDSRIGMIGAGASEIQRTIIAKQMGL
>NZ_CP044549.1|WP_159595174.1|4399164_4399980_-|hypothetical-protein
MKSNTRPDMAITDLLYGVENAVAWITFNRPARRHALGDTTTRQLVCLCQRAAHDPAVKVVVIQGQGDAFCAGGDMEDTFQRGASMDARQWSDRIREGPNALALAIQTMGKPVIASVNGLAVGGGATIALACDLRIASDGARFGFPFARLGITPEFGCSYLLQRVVGVGRAMEWLLLGEFIDAATALQHGLVNRVVEHAALASATRQWADHLASLPAPAVARLKHLMHFARQHDLAATLEQEALALGESFTSIEHRAAVEQFLQRKATASKA
>NZ_CP044549.1|WP_159595175.1|4400183_4401155_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MNRRLVFLASLAALAASPFAHSDVAFPNKAVTFVVPLAVGGGTDILARKLAQNLSTLWSQSIVVENVSGASSIIGTQRVARSQPDAHTLLVTTNGAIVGNRFLFKSLPYDPDKDLVPVAQLADIDMVLLAHQSLAAKNLKELVAQARKDPGSVTYASYGIGSQPHLLMELFNKREGIQITHVPYKGLGPALTSVMAGETMLTLTGRGSGDAAIRSGKTKVLNYNADKRDPLHPDVPVSAESGYPYFRVATWHGVFAPRGTPKEVVAKIHKDILTVLNQPEFREDMVKRGYGVPTRSPDEFAAVIQEEVRATGDMVKAAGLKPE

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Crispr_ID: NZ_CP044549_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044549_5

4490502-4490590

Orphan

Consensus_repeat	Method
GCGCGCCACAGGCGCTGCACTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044549_5

>merge|NZ_CP044549|5|4490502-4490590|CRISPRCasFinder
GCGCGCCACAGGCGCTGCACTCCCAGCTGCGTTCGCTTAGGCCTGCCAGGCCCTTCGGTCCGGTGCGCGCGCCACAGGCGCTGCACTCC

>NZ_CP044549|5|4|4490502-4490590|CRISPRCasFinder
GCGCGCCACAGGCGCTGCACTCC	CAGCTGCGTTCGCTTAGGCCTGCCAGGCCCTTCGGTCCGGTGC
GCGCGCCACAGGCGCTGCACTCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044549.1\|WP_159595250.1\|4508325_4508631_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|214643
NZ_CP044549.1\|WP_159595240.1\|4482135_4482723_-\|response-regulator	unknown	unknown	gnl\|CDD\|381118
NZ_CP044549.1\|WP_159595249.1\|4496919_4506759_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044549.1\|WP_159590482.1\|4480607_4481695_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|366234
NZ_CP044549.1\|WP_159595247.1\|4493449_4496080_-\|cyanophycin-synthetase	unknown	unknown	gnl\|CDD\|237586
NZ_CP044549.1\|WP_159595242.1\|4484707_4485520_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133055
NZ_CP044549.1\|WP_159595239.1\|4479277_4480441_+\|PepSY-domain-containing-protein	unknown	unknown	gnl\|CDD\|377164
NZ_CP044549.1\|WP_159595238.1\|4476726_4479255_+\|TonB-dependent-siderophore-receptor	unknown	unknown	gnl\|CDD\|236643
NZ_CP044549.1\|WP_159595241.1\|4482993_4483392_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044549.1\|WP_159595237.1\|4475607_4476633_+\|DUF4880-domain-containing-protein	unknown	unknown	gnl\|CDD\|226235
NZ_CP044549.1\|WP_159595245.1\|4487532_4489584_-\|response-regulator	unknown	unknown	gnl\|CDD\|274362
NZ_CP044549.1\|WP_159595253.1\|4511440_4513651_-\|type-I-secretion-system-permease/ATPase	unknown	unknown	gnl\|CDD\|274550
NZ_CP044549.1\|WP_159595248.1\|4496109_4496805_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377801
NZ_CP044549.1\|WP_159595254.1\|4513640_4514885_-\|TolC-family-protein	unknown	unknown	gnl\|CDD\|224455
NZ_CP044549.1\|WP_159595246.1\|4491672_4493457_-\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|237586
NZ_CP044549.1\|WP_159595255.1\|4514975_4515425_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377376
NZ_CP044549.1\|WP_159595243.1\|4485516_4486509_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187550
NZ_CP044549.1\|WP_159595244.1\|4486526_4487306_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223099
NZ_CP044549.1\|WP_159595251.1\|4508911_4509457_-\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|272971
NZ_CP044549.1\|WP_159595252.1\|4510238_4511444_-\|HlyD-family-type-I-secretion-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|130902

Protein	Function_ID	Function_description	E-value
NZ_CP044549.1\|WP_159595250.1\|4508325_4508631_-\|hypothetical-protein	gnl\|CDD\|214643	smart00387, HATPase_c, Histidine kinase-like ATPases. Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.	1.85193e-20
NZ_CP044549.1\|WP_159595240.1\|4482135_4482723_-\|response-regulator	gnl\|CDD\|381118	cd17580, REC_2_DhkD-like, second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains. Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	8.83455e-21
NZ_CP044549.1\|WP_159595253.1\|4511440_4513651_-\|type-I-secretion-system-permease/ATPase	gnl\|CDD\|274550	TIGR03375, type_I_sec_LssB, type I secretion system ATPase, LssB family. Type I protein secretion is a system in some Gram-negative bacteria to export proteins (often proteases) across both inner and outer membranes to the extracellular medium. This is one of three proteins of the type I secretion apparatus. Targeted proteins are not cleaved at the N-terminus, but rather carry signals located toward the extreme C-terminus to direct type I secretion. This model is related to models TIGR01842 and TIGR01846, and to bacteriocin ABC transporters that cleave their substrates during export. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	0
NZ_CP044549.1\|WP_159590482.1\|4480607_4481695_-\|IS3-family-transposase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	2.54186e-30
NZ_CP044549.1\|WP_159595247.1\|4493449_4496080_-\|cyanophycin-synthetase	gnl\|CDD\|237586	PRK14016, PRK14016, cyanophycin synthetase; Provisional.	0
NZ_CP044549.1\|WP_159595242.1\|4484707_4485520_-\|glycosyltransferase	gnl\|CDD\|133055	cd06433, GT_2_WfgS_like, WfgS and WfeV are involved in O-antigen biosynthesis. Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	1.32526e-49
NZ_CP044549.1\|WP_159595239.1\|4479277_4480441_+\|PepSY-domain-containing-protein	gnl\|CDD\|377164	pfam03929, PepSY_TM, PepSY-associated TM region. The PepSY_TM family is so named because it is an alignment of up to five transmembranes helices found in bacterial species some of which carry a nested PepSY domain, pfam03413.	5.24029e-53
NZ_CP044549.1\|WP_159595238.1\|4476726_4479255_+\|TonB-dependent-siderophore-receptor	gnl\|CDD\|236643	PRK10044, PRK10044, ferrichrome outer membrane transporter; Provisional.	0
NZ_CP044549.1\|WP_159595255.1\|4514975_4515425_-\|hypothetical-protein	gnl\|CDD\|377376	pfam04519, Bactofilin, Polymer-forming cytoskeletal. This is a family of bactofilins, a functionally diverse class of cytoskeletal, polymer-forming, proteins that is widely conserved among bacteria. In the example species C. crescentus, two bactofilins assemble into a membrane-associated laminar structure that shows cell-cycle-dependent polar localization and acts as a platform for the recruitment of a cell wall biosynthetic enzyme involved in polar morphogenesis. Bactofilins display distinct subcellular distributions and dynamics in different bacterial species, suggesting that they are versatile structural elements that have adopted a range of different cellular functions.	1.5468e-14
NZ_CP044549.1\|WP_159595237.1\|4475607_4476633_+\|DUF4880-domain-containing-protein	gnl\|CDD\|226235	COG3712, FecR, periplasmic ferric-dicitrate binding protein FecR, regulates iron transport through sigma-19 [Inorganic ion transport and metabolism, Signal transduction mechanisms].	1.63432e-74
NZ_CP044549.1\|WP_159595245.1\|4487532_4489584_-\|response-regulator	gnl\|CDD\|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	9.91359e-81
NZ_CP044549.1\|WP_159595248.1\|4496109_4496805_-\|hypothetical-protein	gnl\|CDD\|377801	pfam07277, SapC, SapC. This family contains a number of bacterial SapC proteins approximately 250 residues long. In Campylobacter fetus, SapC forms part of a paracrystalline surface layer (S-layer) that confers serum resistance.	3.07832e-71
NZ_CP044549.1\|WP_159595254.1\|4513640_4514885_-\|TolC-family-protein	gnl\|CDD\|224455	COG1538, TolC, Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion].	1.78391e-34
NZ_CP044549.1\|WP_159595246.1\|4491672_4493457_-\|ATP-grasp-domain-containing-protein	gnl\|CDD\|237586	PRK14016, PRK14016, cyanophycin synthetase; Provisional.	9.53938e-66
NZ_CP044549.1\|WP_159595243.1\|4485516_4486509_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187550	cd05239, GDP_FS_SDR_e, GDP-fucose synthetase, extended (e) SDRs. GDP-fucose synthetase (aka 3, 5-epimerase-4-reductase) acts in the NADP-dependent synthesis of GDP-fucose from GDP-mannose. Two activities have been proposed for the same active site: epimerization and reduction. Proteins in this subgroup are extended SDRs, which have a characteristic active site tetrad and an NADP-binding motif, [AT]GXXGXXG, that is a close match to the archetypical form. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.95817e-50
NZ_CP044549.1\|WP_159595244.1\|4486526_4487306_-\|hypothetical-protein	gnl\|CDD\|223099	COG0020, UppS, Undecaprenyl pyrophosphate synthase [Lipid metabolism].	2.82652e-29
NZ_CP044549.1\|WP_159595251.1\|4508911_4509457_-\|PAS-domain-S-box-protein	gnl\|CDD\|272971	TIGR00229, Sensor_protein_FixL, PAS domain S-box. The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions].	3.52067e-13
NZ_CP044549.1\|WP_159595252.1\|4510238_4511444_-\|HlyD-family-type-I-secretion-periplasmic-adaptor-subunit	gnl\|CDD\|130902	TIGR01843, Hemolysin_secretion_protein_D_plasmid, type I secretion membrane fusion protein, HlyD family. Type I secretion is an ABC transport process that exports proteins, without cleavage of any signal sequence, from the cytosol to extracellular medium across both inner and outer membranes. The secretion signal is found in the C-terminus of the transported protein. This model represents the adaptor protein between the ATP-binding cassette (ABC) protein of the inner membrane and the outer membrane protein, and is called the membrane fusion protein. This model selects a subfamily closely related to HlyD; it is defined narrowly and excludes, for example, colicin V secretion protein CvaA and multidrug efflux proteins. [Protein fate, Protein and peptide secretion and trafficking].	4.23625e-93

>NZ_CP044549.1|WP_159595245.1|4487532_4489584_-|response-regulator
MEVLAERKRSVELLAELNRTQSELSRVKSSATLETDSRLQAEVALGESQERLQLALDAAGLALWDCRYPFTDVYLSARWGELLGDIALEGNWRAADLVERLHPEELDGLRRQLRRVLDGEVQRTSVEYRFKAGEEWVWLEAHAMVAEVDLRGRVTRLMGTQANITKRKQIEEKATQALLMAEQASRAKSEFLANISHEIRTPLNAIMGLNQLLLGSQQSNEHRQWLQLMDDSSRVLLNLLNDVLDFARIEAGKLHLENIAFPLRPLFESTSKTYLEQARLKSVDMKVYMSPELPSSMLGDPLRIRQVLTNLLSNAVKFTPAGGQISLSVDASREAGLVKRLIFKVADSGIGIAPEQHKAMFEAFTQADSSTARQHGGSGLGLAICATLVKAMGGRIRLESSLGQGCKFEVELPVKDISLPKSDQKMAPQTVAKADVLTDRRFENIRVIVAEDNTVNVRLMRDALRQIGCEVRVARNGDEAIKQWREWTADLVLMDVQMPGVSGLEATARIRELERRMQRPPVPILAVTANAMAGDQEAYLAAGMSGYVSKPVDFPRLFQTMSKALETRASGEVRDTQPSEGHAIYPASTRKRNAHIQQTLERKTKSLQSALARRDPTAAQLELEALVEALSALRAERVLRICRGLEMARHAGEWGLFARAFPLLEAEIAALIGQLGSGTVGGT
>NZ_CP044549.1|WP_159595244.1|4486526_4487306_-|hypothetical-protein
MVREERVPALPATVPMRLHSNAAVSEEYERKPEHLTIVLQGHRQWAHDHSLSYSDAVNAGAGRILELIDFCAMWSIKKVTLCVFTDDLLLLPQGGQGDAFGSFMRYITAGAQNLHRNDVRLQIEGALDGLDAITRGLLNHVARRTNLNKGMQLIVAINGLVDPKPSLGLNGTPDDSQVADAARVMLDSAPDFVIRTGGHMPVHRTMLWETRKTALYFTDLHWPAFDAKSLHAALDWYGEVQRSVGIQLTPPLAFQERRH
>NZ_CP044549.1|WP_159595243.1|4485516_4486509_-|NAD-dependent-epimerase/dehydratase-family-protein
MNAIRKVFVAGPASAARQAIVRRLMASGFVADQIDTWDESDHSLYDQAAVRSYLRDSTPDHIYVAVGPWGNPSDNSSRRGTYMGDALLGPVQLIHEAMYAGVRKLLFIASHQVYGGCPVLPMAEEDLAFARPDRAREPLAIAHMAGIRLCEAYTHEFGELLGLTYRSVVVGNLYGPGDDLQPSTAGELLTLMRHIHQAKTFKLSSVNLRCNGFRRADWLYVDDMAEACIGLLDLPDRSYRLLTDERRPHVNLGSGRASTTLELAQAVAKVVGYRGCLNVDGDVADEGADFYLDTHRMRSTGWAPQIELETGLAHMYRDYRQQEQRLAAAS
>NZ_CP044549.1|WP_159595242.1|4484707_4485520_-|glycosyltransferase
MTLGQLDLALHIPDETCVLETAPSLKISIVTGCRDNASTIEGCLSSVAGQTFRNVEHVVVDRHSKDDSPELIYAQRDRLSIVYGGVGETRFEAWNRGIGQATGDVLGFVDAADELASPDVLERVAQAFANPWVSAVYGDILCVDAQDARHVVRHHNVGACSRERLSLGLVPPTTALFVRRSWYRRIGGFAPELKLAADYDASLRLFSHQFFKAVYLERPVVRQRLVFPEVRQLPNALRIPIEELRSLRSARVGGWKALAWHNLSKVGRWL
>NZ_CP044549.1|WP_159595241.1|4482993_4483392_+|hypothetical-protein
MRLPAIKTTADSIKEFFGTRGNLDAPGVTSPALVMLEFYNIEPTGQLLMVCETSPLAAGDWIRIDDLEFSVDEQLSQDEVAQCIFVVSGGALDEVAAVGETANYQVYYSEELKGKLGLVPKRMTLNNDIYHA
>NZ_CP044549.1|WP_159595240.1|4482135_4482723_-|response-regulator
MNATTPEDYCGTFFAAKLLGLSVGTIQALVEKNELTAWKTKGGHRRISMESIRKYQRKHGLAETAEKAKFLKVLVVEDDPATLEMFKSTIDSWTLPIDVSLMSSAMEALIDINTLKPDVLITDLNMPGVDGFELLRTLRANASFSSMVLVAMTGLSPAEVTEQGGLPAQTVTVQKPVDMRWFNGFVAALVALRQS
>NZ_CP044549.1|WP_159590482.1|4480607_4481695_-|IS3-family-transposase
MKKSRFTDSQIIDALKRAEAGLTVPELCRELGISSATFYKWRAKFGGMDASLMARMKELEAENARLRKMYVEEKLKAEVVAEALGKKVVKPSRRREMAQQAVRQRGLSIRAACQAFQISQACYRYEARRGLEDDEIAQWLLRLTDNNRNWGFGLCFLHLRNVRGLPWNHKRVYRVYRELELNLRIKPRKRLVREKPEPLTVPKHSNEVWSMDFMHDQLEDGRSIRLLNVIDDFNREALGMEVDFSLPSQRVIRTLAQIMAWRGRPNVIRCDNGPEYISATLLNWASARGIHIEHIQPGKPQQNAYVERFNRTVRYEWLSQYHWSDLDEVREYATQWMWRYNHERPNMALGGITPKQRLAMAA
>NZ_CP044549.1|WP_159595239.1|4479277_4480441_+|PepSY-domain-containing-protein
MKAATLRAWSWVHKWSSLVSTVFLLLLCITGLPLIFHEEIEHAFEPAPQATGEFVAGTQAGEAPSLDSVVAHALQQARGGHVNFVLIQREESLVQVGTSPSRQPSPDESRTHLYDLHTGAVLQAPSAGDDGFMDVMLRLHTDLYMGLGGTLFLGFMGLLVAVAVVSGVLLYAPFMSKLPFGTVRHDHARRTRWLDMHNLLGIGTVVWLTVVSLTGTINTLEVPLGHLWRNNDLAAMRQRHAGAPPAQAFASLHQVLAAARETAPKSQVDSIIFPGMKISGPRHHLVILRGDKPATRQLVQVMLVDAESGRVSDHASMPWYVQALSMSQPLHFGDYGGIPLKVLWAVLTLTSIAVLGSGLYLWLTKPSKARIKSRAPIDDIRSGDLRP
>NZ_CP044549.1|WP_159595238.1|4476726_4479255_+|TonB-dependent-siderophore-receptor
MHHRPYRLPQQPTARIARVFHCGALAYAAGPALAVKGVAIAAALMAATAPTLVLAQAADTQTRDYSIPAGPLENALNRFGRETGILLSFTPETAEDLHSGGLQGRHSVQSGLNALLAGTGVQAIRQPNGSYLLVKSAAPPSPAPAASGPAATLQTVTVTAERFEEQATGPVGGLVARRSTLATKTDTPLLETPQTISVVSREQVELQDAQSVTRALEYTPGAVAAFGGTNSLFDVVQTRGFFARDHLDGLRLPFSAYSVAVPQFDPYMLERIELLQGPASVLFGQSSPGGVLNMVSRRPQTETAHEVLLQTGSHNRTQLAFDSTGAIGEDGKLFHRLTGLARQNDGQVDFSNEKRELIAPSFTWRPSADTSLTLLTHYQRDEQLPQYQAVPAAGSLRPNPNGPIPRTLMTGDPGWDHIARDQYGVGYALEHSINEGWTLRQNMRHTEVKVDSRALPGYMLAADNRTLMRVASASQAEGSIFAIDNQAQMRFSSGTWAHTLLMGLDYMRQHDDYRFASQLAPSIDLYAPVYGVTIPALIPRLSTRHTMEQTGLYVQDQMRSGRWVLTMGGRYDEADSNTANRQAGTSVRKSDGAFTWRMGVNHVYDNGLAPYASYSTSFEPLGGTDFTGAPFLPTEGRQLEAGIKYQPAGGSTQLSLSAYRLTQENVLTPDTTPGRASFSIQTGEVQSQGISAEARMRPLRNVDLVATYAYTDSQVTRANPSAPGVSLLGKPLSRTPRHLASLWLGYRFTQSSFKGFTAGLGVRHIGENYADTAITMKLPAVTLFDIALHYDFGASRRQMDVWRLSLGVSNLAGKDFISYCLNTTQCFYGQPRTTQVTLRKRW
>NZ_CP044549.1|WP_159595237.1|4475607_4476633_+|DUF4880-domain-containing-protein
MTANSHDSPPASIPAEVAQRAVEWLVELQSDHVSPAVQANWQAWRLAHPDHELAWRHIEAMEGQIFGKLRHLASPVKSAMAQASLTPPRSLARRRAITTLAVMLFAGGAAWSVRQDGRWSTFVADYGTATGERRTVVLDDGSTLELNTASAVNVAFSETERRVRLVAGEVLITTASDKAARPFLIETAQGEAEALGTQYIVRLHEATSDVAVFEGAVRLTPREASARPHLLQAGRRARFNTHAVTAEQMADRDSAAWTDGIIVAKGMRLADFLTELARYSQRPLWCDPAVADLRISGSYPLADIDKVLDTLSAMLSLQVETVTRFWGLQTVRVQLGPRRPA
>NZ_CP044549.1|WP_159595246.1|4491672_4493457_-|ATP-grasp-domain-containing-protein
MFEFAYEAVFHGPNVCALGPVLAARVRFSRSLPPGALATSCARLRALWPEWLNQDGPATDEETEAARLLAAWALGALNEVRGFLHDAGAQAVPGGARLWVGFHHVGVTKMALELAQRALAEAARPGVGFSREAMEVPLQRFWALCRKYHPDYQARILMEGARARGVPVLPFVNGSRYWQYGWGTRSRVFMESASNTDGFLGSQWQKSKVLSHAVFTSLGVPTPKHRLVSQPSELEAAADVVGWPCVVKPMDQGGGRGVTAGIASSGSLHKAFAHARRYTQGPVMVEAFVPGDDHRLMVVEGRLMAAIRREPSSVVGDGQRTLRELVQALNSQRSSNMVKSRYLRTIASDTVLAEHLAGQGLTLETMLAAGQRVTLRSNANLSSGGVCVDVTAQVHPMVRQLAEAVVQAFGLGTAGLDYITTDIGGAPSLTGGRLIEANTIPGLDAVIAAGWAPETIAEAVLGERPGRIPVTLVVLPEATVAKATDDLLKHSADPTIGWVCGAQGGIGGLSLQGINKEAWSAVRAALRHRGLEALVIVSTPTDLIRNGLPVDKMERAVICGAELPLDWQGVLQRCVAEVEHLDDWDGYVKRIDGM
>NZ_CP044549.1|WP_159595247.1|4493449_4496080_-|cyanophycin-synthetase
MHGLSDPTAVLTLQIEGRIDGDAVQRLVSRARANFAHADGIPAEGLPEALLSGPHLRGGVEMAAASMLAALCVAFQRAARDAVGLARVVSASKGAWVLALPYHRREVLHSGLPLMLDHFRLWIKQAIAPAAQKKLAEATSQWLRGVQGGSLAPNTLRFALAARELGHPVSTIGYGVIQLGWGSRQQRMESSFTGQTSVLATRIAKNKPLANALLARAGLPVPRSALVSNWDQALKVAQELGWPVVVKPANLDQGQGVVPDIHDEDLLRRSFERAAALSSGRVLVEKHVEGADHRLLVVGGRLLVATRRLPGGVTGDGHHTVAQLLAKLNADPRRGTDQRSLLKTIELDEEAATRLAEQGLNADSVVELGRFVTMRRTANISTGGTALDVTDQVHPDNRWLAERAARVVGLDIAGIDLLCPDIARSWRKVGGAICEVNAQPGFRPHWLGDPARDVNAEIVEWLCRGGTRVPTAAITGTNGKSTTARMLHHIWLATGRCAGLSSSSGVWVGSDRMLEKAPVGVTGARMLLDDPGVEAVVLELPRLGLITLGHPCDHYDVAALLNVQDDHIGVNGIDSMEAMARFKAQVLERASQAVVINADDALCLSVRGQAGATRQVLVSRVGDANPAVGAHLAEGKDAVLVAWHAGAEWIVMAQGETRTPLMPLNEIPATMNGLLRFNEANALSAAALAWAQGIPLDTVRAALGTFANTLEHNPGRYNVIGGFPFTVLLDFGHNPDGIREICNVARRWSVAGRRRLVTSHIGNRHRSHVALLAPDVAAVFDDAVISQDAWFVRHKSDWTGEHPEVQHLAQLEQSLCEAGMDGANVTIIADVLEAVRQGLQTAEAGDLLVLLVGEGALPVIRQALREREAAVAVSCV
>NZ_CP044549.1|WP_159595248.1|4496109_4496805_-|hypothetical-protein
MYKNLVPLRHTEHAGLRLLPVSNYDFASELMLAPIVVDELAEAAREYPIVFPRDAALPAVLLGVQRGRNAYVGDNGQWLASYVPAHIRHYPFMLTRLPGKGDGQDHVVMMDADSPLWSKIEGEPVFDGESLTPVAQRSVDLLRAMSRRQVTTRAMVQAIAAAGLFVERTVRVKRPGHPDARVSGLRAVDEKAFNALSDEAFNALRKSGALPLVYAHLLSWANFRQGPIGRA
>NZ_CP044549.1|WP_159595249.1|4496919_4506759_-|hypothetical-protein
MVPPVQLVGLPPRIRGHYCTVGAGVAAVAGAGGSSGGSTPPAAPAPAPISPPAPAPQPEPEPTETVHQLTTGLDNVKRCGVDRIIGSSTTFQPADVVNGGEGIDTLQLQLTGGTYGDGAIVSNIEALDVRALAGDSGAVNLYLTDWDDSLAKLNIIEAKQDVAVRDQQTLADVSITKSSKNVALAYEPNVTAGEDDELNVSVNAFKGGLTIDDQVEGVRLSVDDDAGSPNASNMSINALSSTTIVGGRSGQGFGLTLTGEDGSAASLDSSEFVGNLTLNAGSNLKTLTTGAGDDVVTSTSGIYQSDAVYDLGQGNNSLNVSGTVGGSVNAGAGNDTISISGSVNEGASIDMGAGSNTLTAGVVEGSITSGAGADSITVDGIEGNAVVSLGDGDNEVIVGAHGIGEGASLTLGDGNNSVHTTGGVNGVVGEDSETGVSITFGDGNNSFLVATEFDGEDVPVGGAGVGHANIVFGDGDNRMDVATQVVNSSVTFGDGDNILQVVEDVRDSSVSSGDGQNAVLIRSDLEGSSVSFGSGDGNVLATGNDVFESTITFENGNENELTVYGGVADSSTSFGAGSGNVMYVGEDLSDSTVAFGAGEDNMLLVSGGAHNTSVSFAGGSADANIAGQVTSGDGVVSEFSFAGDGNTMDVNAFGGEDSNGIEGHELTTIVGEDMVIEEVRVNVDFGAGGNNTLLVRNGSVQLADISFGEGSANNVGIDKNLQQSSVTFGGEDSTGGAGNGLYVGNDIRNSQVAFFGAASTVEVGDDVTASQLSFGAGANRVEISDDLEDGSSISMIGGGSRIYVGGDVEGSSISIAGGGNSGQMAAVGEDAPDDAGVFVLGDVDASSITVGGGNNIVYVGEDVNESAISLTGEAGEDTLSVGDDIVESTVSFAGAGNVLSVGDDVEGSSLSFAAGGNTVTIGGDVEEESEITLAGGGSVVSIGDDLDNSTVALGDGGNSVNVGGELDDGALISATGGDNTVVVGGKVSDGSQINLGGGADTVTVGSNEHKQGSVGGDGGQAARIDVGAGDDQVTLIGSKHYGNTLVRSGGALEGGQGNDTLTIKATSDVNVVGRTEHQELSVELAESYDVGDVVTLKVGEEEFTHTVEYTTAQVLEFTFGGSYSYSANQTYSVTVGGETYSFLFPGAQGGPGAAAQAVADGIKAAIDSADPSIEGFGSINVVAGEVEGTYTLSLTGTSADAENVDASSSHSAAAGADGADRTVQTAEEVASALEALVDCESTTFSASIVDGKIVLTGNGCAIAADVSASLWLNEAEVDGAITTEQLADASISGFETLKLEILNNVGEDTGLTAREITADFSYISGVQNIVLDSQVKIDAVTVVDVIGEQELVNGAYERTDEYADNCDIDGTTEFNLLNLKGGEAITVRGHEVTATGSKQVDGIQIGDQDGDHHVGDVISVSLGGQTYSMVITPEDLDGESAVADANAIATRLAGILQEANNEDWPFSVAVDGRHITLIGTDSSLSTEISVSHTRPNASPSPLYGSEGSFEDRIDFNCLDSIQTGDVISLQVGEELITYTVLQEDLDACCDRHIGDVIAEKVAAAVNGAGNTGVRAFFGVVTLGGELEASWSVTRMESSYVNKTFAEFVQASDAEDDSDIDVTAKATLAENTDNDTMDLTVDGYGAFDLEIVGDGVGQYEHLDLNVVDEFSHYINTNGHQGNFSESIVLTGGAAGASIYLDNIRAADVNSTSEANLTVEQYDTDLQNALVGEDAVVNVSTGSGDDHLITNAWALVNEGSSVDLGTGKNTLSLGWGWVEDCGDAVPRTIAGADLARVSEIEGLTQLHRLNMLNGVVLGEDATLSMMETSVPNTVEEIDLWAVTVTGEDIDLTISGTAASLLLEASEGDLDLQDTGVLTAVGVTDLSVRGLGDVTFALGNDALNTLSVVSRDDEASVYVRDGVNRTVTIGEASLEGRGDDAKFTIRDNTDGSVTVGSLSAEADSDARLAIYDNTNTDISVGALGGVTLRGEYEATVSISGNGDDKLEADQVITLGDLSMYAGEDALVTIENNVANTITLGAVDMVSCEEDTSFRVANNSGLDYEEGMSASVDWSTLNSGAIAMDAGDEASLAIEGNTWAKVELATGEDEGIDISARNDIEFKVKDNTNVNVAMGGVTLNSADRISASVSGNVTDSEDLYLSSVSIGDFSATANDDVNLWMKDNVVVDISLGDVAMTSYTDDVRLYIKDNQDTQFSLGSVALSALDDAALVIRSNVAGEDEGPGLQMLVDGDITIASQEDDATLSFKGNSGVQFGVMGDVSLKAADDVRFELSDNKATLVFMPGSAEGEDSEASPAIKLESTDGDVRLYIKDNGGEDSQDSFNGFAAVLGAVDIDAKDEAKVKINGNENSLIAVGLPASAVTEGVEGVFSGLAGQILENMDGIQQALSSAGPGIEVDATSIDFEIENNFTSGEDFQDDFNVVLLGSTALTAKDTNDVDAHADARMSILGNEQTIIVAGDLQMSADATSSGEDAYAETGLYIGETGFFGASGSNGVQGNETVAIVMGDVSLESNATTVFDEATGLAYVELSANENVRIKLGDVSSSASATSTYGAAYAGAGVAVLGNIGGEDIGGEDDSWIEMGDVTITANTNPIGEDEFTPMSVPMTISEARAAFVLMENEELHVKVGDVDVSAAATGGEDSEAVAVFHLDENTDSSFEFGDVSLSADAKTGFDFAGFSIVDQSNVDVSAGDIRVQTTGARGLAGVAVGAYSNQGYSYLTGTNQGVDYFSVGLQYTPAATDANYETDVALGNIAVSAGNDAAVLLSADSHGSLAVGNIHVTSATAEGAVSGNIFFYMNDVTLNSAVGEDAADHLGNALAAVEAANIAVQDAGSDDVALALAQEALETAEAEVEATEAFLNALEDGISIVLDGSNGADADNTVYATLIDTPDVHSLVISGADANVFLEGEMDDFATLDLSGVTDFAYVETWGADFSNGSDELKLSDHIVVKIGTGDLQYNAMYGVRDEQGIGRGFTGSLVQDAGTNGNFHGDWNGSSSGWYSLGESGDNYLAPTPHEIYIETWGAPSSTENQDVYKFTVDGTSYSVAIEKYISGEDTHGEDIFSYRMDDFHIGLSDTDVGLEAFEESLGVASFEWNGVDRFILTGPSDGSALKPVTTATMVVDNNDTVNQPMEVENIPGKVATDGIGNAVQEVFQFVGDEIGDVVIGGFFAKPVGADNVDGTLRWGDRLDFSQFDLNGDASGMGGANDLTISVVNDDQGYFSDVLITFNTAGMEDSSILLVGVGDQYSTSTDVITNVTNSIIFA
>NZ_CP044549.1|WP_159595250.1|4508325_4508631_-|hypothetical-protein
MKFTLPGGHVEVRVEVCGSRLHVEVKDDGLGMDPATVDDLFLLFAQGQAQRETHQPGLGIGLALSRMIVEMHGGVISGASEGRGLGSVFRFELSGAELKAP
>NZ_CP044549.1|WP_159595251.1|4508911_4509457_-|PAS-domain-S-box-protein
MSTSSAGGANVPPPVRPALSSADRFQLVVEAIDDYAIYMLGPDGLIESWSPGAERLKGYRATEVLGKSYSIFFRSQDVAEGVPEWQLSRARLHGKTEEEGWRVRKDGSVFWANISSVESLTMMAPSSLAKITRDVTERRRLRELERSLKRMDEFIACLATNCATRWGRFAMRQPSFRSTVA
>NZ_CP044549.1|WP_159595252.1|4510238_4511444_-|HlyD-family-type-I-secretion-periplasmic-adaptor-subunit
MKILWFLEPNKRSKSDQGPLSEQLRGSRWVMWVTFLSIGLFVAWAWHAELDQVTRAPGSVIASSRTQLIQSQDGGTLEEMLVREGDKVEAGQLLARIERTRAESAFLETRAKAAALSASLARLQAEVFGGQPRYAAELKNYPDFSRSQNDLLRKRRAALDEDLTAIRRMKSLVEEELSLNLPLVQSGDVSRTEVLRLQRQVADMQAQMTNKRNKYFQDAQAEFNKTQEELAGVQQILAQRRNQLDQTELRAPLRGVVKNVRITTQGGVIRPGEEVMQIVPLEDDLVIEAKVSPADIAFLTLGLDATVKIDAYDYTVYGGLPGKLIFISADTLSENLRQGEDPYYRVQVRTTSREFSKRAHSVLEIQPGMTATIEVKTGQRTVLQYLAKPIVKTLGDSLGER
>NZ_CP044549.1|WP_159595253.1|4511440_4513651_-|type-I-secretion-system-permease/ATPase
MSANTSVEALDASASPLPQDQALSGLLSRLASLLGHAVPAFRFSMLERSQDGIEMATLAPHRRAREMWKARFSGAQIRELTPAVVKRGDYPLLWISSSGVDVRIVRGRLSHGAFSTEGMDGISQEIDEANVRDGHLLALRADESTEGAREDGPQTATDWFAFAIRKHRRVFLDGVFATFMISAIGLTASLYTMQVYDRVVPTKGFSTLWVLTIGVLLAVVLEFTMKQVRAHMVDRASKVIDQELSSVFFDKALAIRMDARPSTVGTFASQIRHFESVRNFMTSTTLFILADAPFALMFIGVMAMIAGPVALVPLVMVPVAVIAGLFFRGSIERLSAENMQESNRKNGLLIEAVDGIESVKAAGGEWKMLDRYRDLTATIAASELQLKALSTRSTNLAQTIQQLNYVGLIAAGAYAISSGQLSMGGLIACSIISGRALSPLAQIPQLVVQWKHAKIALKSLDAIMAMPSDRSSHQRLVVPERCAGQLRLESATFGYREDKPILEIADLRIQPGERIAVLGAVGSGKSTLVKMLSGLYKPKTGAAYLDGVDMDQLAPEFVREHIGYLPQDVRLFSGTLRENLTLGLPTPSDSVIFNAARLTGLDQAIQSHPKGLELEITEGGRGLSGGQRQLVGLTRLLLARSSVMLLDEPTASMDVQLESRVMKHLFQEAPPESVLVVVTHKVGMLPHVHRIIVVDKGRIVMDGPRDQVLARLSGQTPNAITGRAAAAPHTHKEISS
>NZ_CP044549.1|WP_159595254.1|4513640_4514885_-|TolC-family-protein
MFSLTVAACGIGMFCTHLAASAQPVPVDLGTLMSEAVTQHPDVRSRKSNARAAGYELEGARWGRYPSLTTELQTQSGGPQTVIKVEQPLWTGGRITSRIGVADAGVGEAEAAVAEIEQNVLGQTAGAFFEILRLESRLDAARASETEHKRLFDIIQRRVQSQVSPATDQTQAAARLNQAITERIQTQRQIEAARLALEQMVGRKVAELAPPPHIGLGNWNEDSLLDAALSFSPERRRLEAQVAVANAQIDLARSQLMPTVVAGYQSRLGNLLPGEDRGRLYVALQLQTGAGLSSMSGVQVAISRKQAALDAIDALERTLTQQVRSIWSERQALGRQVEPVRALLSGADEIVASYLRQFQVGRKNWLDVLNALREKTQAYYALADLESPILYAEVRLLLLAGQLNAQNPIPNHVR
>NZ_CP044549.1|WP_159595255.1|4514975_4515425_-|hypothetical-protein
MFSRSKTKSDNASDVRVAPLPAAQSAAPVSGWGAKAVKAIPVAEKPSIISEGLVMRGDLDSSGVLHVEGGVIGNVKVDSANVGAGGFIEGHLVCSSLTVKGRFDGVLICDELIIAASAQVKGQVSYRFITISSGAQVEAEVEWRAAEGV

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Crispr_ID: NZ_CP044549_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044549_6

4679739-4679833

Orphan

Consensus_repeat	Method
GGCGCAGCCGTCCCTCGATGCCCCTGG	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP044549_6

>merge|NZ_CP044549|6|4679739-4679833|CRISPRCasFinder
GGCGCAGCCGTCCCTCGATGCCCCTGGGTTCGGGCACGCTCGCCGGAGAGGGGACGGCCTCTTGGGCTGGCGAAGCCGTCCCTCGATGCCCCTGG

>NZ_CP044549|6|5|4679739-4679833|CRISPRCasFinder
GGCGCAGCCGTCCCTCGATGCCCCTGG	GTTCGGGCACGCTCGCCGGAGAGGGGACGGCCTCTTGGGCT
GGCGAAGCCGTCCCTCGATGCCCCTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044549.1\|WP_159597038.1\|4675860_4677255_+\|efflux-transporter-outer-membrane-subunit	unknown	unknown	gnl\|CDD\|182103
NZ_CP044549.1\|WP_159595357.1\|4683283_4684078_+\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270233
NZ_CP044549.1\|WP_159595352.1\|4672603_4675801_+\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|273335
NZ_CP044549.1\|WP_159595359.1\|4684660_4685935_+\|ribulose-1,5-bisphosphate-carboxylase	unknown	unknown	gnl\|CDD\|173972
NZ_CP044549.1\|WP_159595354.1\|4679880_4680909_-\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|380530
NZ_CP044549.1\|WP_159595347.1\|4666601_4667375_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_CP044549.1\|WP_159595356.1\|4681819_4682491_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223836
NZ_CP044549.1\|WP_159595351.1\|4671228_4672527_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|184990
NZ_CP044549.1\|WP_159595360.1\|4685939_4687256_+\|four-carbon-acid-sugar-kinase-family-protein	unknown	unknown	gnl\|CDD\|377757
NZ_CP044549.1\|WP_159595358.1\|4684116_4684659_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|372667
NZ_CP044549.1\|WP_159595361.1\|4687259_4688858_-\|inorganic-phosphate-transporter	unknown	unknown	gnl\|CDD\|376541
NZ_CP044549.1\|WP_159597037.1\|4668984_4669416_-\|MaoC-family-dehydratase	unknown	unknown	gnl\|CDD\|239534
NZ_CP044549.1\|WP_159597039.1\|4682508_4683237_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP044549.1\|WP_159595355.1\|4681133_4681823_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223836
NZ_CP044549.1\|WP_159595362.1\|4688934_4689540_-\|oligoribonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|235429
NZ_CP044549.1\|WP_159595348.1\|4667371_4668988_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|235730
NZ_CP044549.1\|WP_159595349.1\|4669445_4669919_-\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|239538
NZ_CP044549.1\|WP_159595346.1\|4665486_4666479_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP044549.1\|WP_159595353.1\|4677382_4679329_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223587
NZ_CP044549.1\|WP_159595350.1\|4670146_4670929_+\|DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182100

Protein	Function_ID	Function_description	E-value
NZ_CP044549.1\|WP_159597038.1\|4675860_4677255_+\|efflux-transporter-outer-membrane-subunit	gnl\|CDD\|182103	PRK09837, PRK09837, Cu(I)/Ag(I) efflux RND transporter outer membrane protein.	1.57667e-85
NZ_CP044549.1\|WP_159595357.1\|4683283_4684078_+\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270233	cd01072, PBP2_SMa0082_like, The substrate-binding domain of putatuve amino acid transporter; the type 2 periplasmic binding protein fold. This group includes the periplamic-binding protein component of a putative amino acid ABC transporter from Sinorhizobium meliloti and its related proteins. The putative SMa0082-like domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.36698e-93
NZ_CP044549.1\|WP_159595352.1\|4672603_4675801_+\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|273335	TIGR00915, Probable_aminoglycoside_efflux_pump, The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family. Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate].	0
NZ_CP044549.1\|WP_159595359.1\|4684660_4685935_+\|ribulose-1,5-bisphosphate-carboxylase	gnl\|CDD\|173972	cd08207, RLP_NonPhot, Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria. Ribulose bisphosphate carboxylase (Rubisco) plays an important role in the Calvin reductive pentose phosphate pathway. It catalyzes the primary CO2 fixation step. Rubisco is activated by carbamylation of an active site lysine, stabilized by a divalent cation, which then catalyzes the proton abstraction from the substrate ribulose 1,5 bisphosphate (RuBP) and leads to the formation of two molecules of 3-phosphoglycerate. Members of the Rubisco family can be divided into 4 subgroups, Form I-IV, which differ in their taxonomic distribution and subunit composition. Form I-III have Rubisco activity, while Form IV, also called Rubisco-like proteins (RLP), are missing critical active site residues and therefore do not catalyze CO2 fixation. They are believed to utilize a related enzymatic mechanism, but have divergent functions. The specific function of this subgroup is unknown.	0
NZ_CP044549.1\|WP_159595354.1\|4679880_4680909_-\|substrate-binding-domain-containing-protein	gnl\|CDD\|380530	cd06307, PBP1_sugar_binding, periplasmic sugar-binding domain of uncharacterized transport systems. Periplasmic sugar-binding domain of uncharacterized transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily. The members of this group are predicted to be involved in the transport of sugar-containing molecules across cellular and organellar membranes.	8.93124e-110
NZ_CP044549.1\|WP_159595347.1\|4666601_4667375_-\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	4.93562e-64
NZ_CP044549.1\|WP_159595356.1\|4681819_4682491_+\|ABC-transporter-permease-subunit	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	1.95851e-75
NZ_CP044549.1\|WP_159595351.1\|4671228_4672527_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|184990	PRK15030, PRK15030, multidrug efflux RND transporter periplasmic adaptor subunit AcrA.	9.45257e-92
NZ_CP044549.1\|WP_159595360.1\|4685939_4687256_+\|four-carbon-acid-sugar-kinase-family-protein	gnl\|CDD\|377757	pfam07005, DUF1537, Putative sugar-binding N-terminal domain. This conserved region is found in proteins of unknown function in a range of Proteobacteria as well as the Gram-positive Oceanobacillus iheyensis. Structural analysis of the whole protein indicates the N- and C-termini interacting to produce an interacting surface into which a threonate-ADPcomplex is bound, suggesting that a sugar binding site is on the N-terminal domain here, and a nucleotide binding site is in the C-terminal domain (manuscript in preparation). There is a critical motif, DDXTG, at approximately residues 22-25.	1.86992e-54
NZ_CP044549.1\|WP_159595358.1\|4684116_4684659_+\|VOC-family-protein	gnl\|CDD\|372667	pfam13669, Glyoxalase_4, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.	4.71372e-29
NZ_CP044549.1\|WP_159595361.1\|4687259_4688858_-\|inorganic-phosphate-transporter	gnl\|CDD\|376541	pfam01384, PHO4, Phosphate transporter family. This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.	9.55995e-72
NZ_CP044549.1\|WP_159597037.1\|4668984_4669416_-\|MaoC-family-dehydratase	gnl\|CDD\|239534	cd03450, NodN, NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their legume hosts, a symbiotic process that requires production of Nod factors, which are signal molecules involved in root hair deformation and meristematic cell division. The nodulation gene products, including NodN, are involved in producing the Nod factors, however the role played by NodN is unclear.	1.66281e-64
NZ_CP044549.1\|WP_159597039.1\|4682508_4683237_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	6.14414e-135
NZ_CP044549.1\|WP_159595355.1\|4681133_4681823_+\|ABC-transporter-permease-subunit	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	1.30022e-70
NZ_CP044549.1\|WP_159595362.1\|4688934_4689540_-\|oligoribonuclease	gnl\|CDD\|235429	PRK05359, PRK05359, oligoribonuclease; Provisional.	5.5348e-124
NZ_CP044549.1\|WP_159595348.1\|4667371_4668988_-\|AMP-binding-protein	gnl\|CDD\|235730	PRK06187, PRK06187, long-chain-fatty-acid--CoA ligase; Validated.	4.05908e-124
NZ_CP044549.1\|WP_159595349.1\|4669445_4669919_-\|enoyl-CoA-hydratase	gnl\|CDD\|239538	cd03454, YdeM, YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.	1.27577e-52
NZ_CP044549.1\|WP_159595346.1\|4665486_4666479_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	7.07506e-110
NZ_CP044549.1\|WP_159595353.1\|4677382_4679329_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	1.97323e-129
NZ_CP044549.1\|WP_159595350.1\|4670146_4670929_+\|DNA-binding-transcriptional-regulator	gnl\|CDD\|182100	PRK09834, PRK09834, DNA-binding transcriptional regulator.	6.41591e-82

>NZ_CP044549.1|WP_159595353.1|4677382_4679329_-|DEAD/DEAH-box-helicase
MSDSFEERGELSPEILSADADTDTSTTVSEAPVAPNGFELLGLAPELVQACVDLGYTQPTAVQNNVIPKAMQAEGQQRFADMMVSSQTGSGKTAAFLLPVLHTLLQQRAENDAKERAERERLAAEAIARGEAPPKAPKRKDPTSPRNFKAATPGALILCPTRELAQQVANDAIDLVRHCRGLRIANVVGGMPYQLQIARLQNADLVVATPGRLLDLQRSQQLKLDKVQFLVVDEADRMLDLGFSDDLAEVNDLTSERRQTMMFSATFAPRIQQLAMRVMHENGKHVQKVQIDSPQEQHANIKQVLFWADNADHKRKLLDHWMRDTTINQAVVFCSTQVECDGLANDLQQSGFAAVALHGALSQGMRNRRLMALRNGQTQFLVATDVAARGIDVPTITHVFNFGLPMKAEDYTHRIGRTGRAGRDGLAVTFAEFRDRRKIGDIEAYTRQRINVETVPGLEPRQRAPQPEFGGRGRPGGRGERFGGGGDRNYADRSGFNARGPAPRGPRFEGRSEGRPEGRFDAAPRADHGRPGPRFDPRFEGREEPQGRNDNRFDHRGEGRGDQGGYRNDTRPAGRSFDRAPTGARPGFGARPNNGFSSFGRGDRPAGGDRGGFSDRGNAERGAMRGGEFAPRRSEGGPARPVARRAPR
>NZ_CP044549.1|WP_159597038.1|4675860_4677255_+|efflux-transporter-outer-membrane-subunit
MPLVLLSAAVLAGCALTPPAPPDVQGVVPPALGQSQPPANATQQALDEAQALAWVQHPGLRQTIAQALTHNRDLRTALFNIERARAQYGIASAAQLPTVAANAQGSRTRTPGDLSSSGNPTTSTQITAQLAITSFELDLWGRVRNLNEAALQQFLQSEANQQNVRITLVADVANAWLNLAANQSRLKLAQDTLAGREKAYQLTERIFQLGATSGLVLAQNRSTVETARGDVAAFTAQVAKDRNALILLVGNGLNADWLPTADTLQGTQAPAALLERPATIDSSVLLQRPDVRASELNLRAVSANVAAARAALFPTISLTTSVGTGSRELDGLFGSGNGSWSFVPQIRLPIFDGGSGRAAVNVAQANRDIAISQYEKAIQTAFREASDALAERAQWQARLSAQEAVVAANAQAFQLSEARFTSGVDNYLTVLDAQRSLYAAQQNLIALRLSEQANRIALWKVLGG
>NZ_CP044549.1|WP_159595352.1|4672603_4675801_+|efflux-RND-transporter-permease-subunit
MAYFFIHRPVFAWVLSIVIMLAGALSIFTLPLEQYPDIAPPRVSLNATYTGASAETVADSVTQVIEQQLKGIDSVLYMSSTSDSAGRSRTQITFAPGTDIDVAQVQVQNKLQTAMNRLPEAVKSRGVFVNKGGQDNLMTYVFTSPDPLVTQVAIGDYISSNVVDVISRIDGVGDVSVYGTNYAMRIWMDPARMEQFALMPSDIISALTSQNAQVSAGQLGALPAVKDQMLNATITARTKLKTAEEFRAIVLKSANDGSLVTIGDVARVALEADNLLVKSRLNNRPGAGLGIVLADGANAMKVAGAVNAKMAELAPFFPDGITGVISSDTTPYVKASIKEVAITLFEALLLVVIVMFVFLQNLRATLIPAIAVPVVLLGTFGVLSAMGYSINMLTMFAMVLAIGLLVDDAIVVVENVERVMHQEGLPAKEATIKSMREITPALVGIGLTLSAVFIPMAFFSGSVGVIYRQFSIAIVSAMAFSVLVALTLTPALCATILKPTNHLHEGAPARKGLLGWVDRFFRWFNAGFDRNATRYQGIVGKLLTRSKRMMLIYALLIGGVVLMFQKLPTSFLPVEDQGFFSVSVTMPSGSSDAQLEVVLREINDYFYQQPDVLRVNSLAGNNGNQSSGMIFVRLKDWSERPDASQSADAIARKATRDLAKIRSARIFVSLPPAVRGLGSSSGVNFMIKDINGLGHEALRAAKDRAIEMAGQRPELRNMRTTDFDNTSELQVVVDDRKAAALGLSTNDINSVLSSAMGGSYVNDFVHNGRVKRVYVQGDAPYRMLPQDIGQWTVRNRSGEMVPFSTFSTTRWTSSAPQLMRYNGSPSMEMQADAAPGVSSGAAMRAIEEIMSEMPVGIGYEWTGASLQERQSGAQAPLLYAISILFVFLCLAALYESWSVPFSVILAVPLGVIGALLATYTRGLSNDVYFQVGLLTTVGLASKNAILIVEFAVQLQNQGRSIVQAVVEAVRLRLRPILMTSLAFGFGVLPLALGSGPGGASRQAIGTAVLGGTVLSTGLGLFFVPVFFLLVRSWVSRRTKKTPEPADTPHAHTGTGTQPLATQGDA
>NZ_CP044549.1|WP_159595351.1|4671228_4672527_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MPFTATTSVDFSTSPVAAYPYGAGRSMRLRWTALGFVLAGVATLAACSGKDASSATAPPPPPGVGYITIEPKAQGLHTDLTGRTKASQSAEVRPQVSGILQKRLFTEGAIVKAGQPLYQIDSRSLQAAVSSAEAALAKARASAQTSKANAARNAELVKIDAISRQANDESQAQAAQGAADVAVAQAALENARINLQYSSILAPISGQIDLSTVLPGALVTANQTQALTTISQLDPILVDITQSSAELLELRRQWQAGVFGKVEGSGAKVRLILEDGSRYPHVGTLQFTGTSVSQTTGAITLRATVPNPERVLMPGMYVRAQLATGEASEAVVIPQPALRRDPAGNPSVQVINAENKIEKRPIKLGQALGSQWMVTEGLARGDRVMVDGFQKARVGQNVTPLEMRMEGGRVVTAQATADAGPGKAPAKATPAP
>NZ_CP044549.1|WP_159595350.1|4670146_4670929_+|DNA-binding-transcriptional-regulator
MSSSPPVRAVVRAIDLLQALNRQAVSTLDVLHAQTGMPKPTLVRLLQTFENRGIVKHAPQHGAYFLTSGVRSLSSGYHSEPMIVEAAAPLMDELTLRVKWPTAVAMLDHSAMVVRYSTIPLSPLSMRHSTINFRLSLVTRALGRAYLAFCPSDQQEALLKDIQTSPHQPEDEAVRDRGALDHVLAKVHDAGYALRDPTVVPATNTLAVPVFDTHGVAATLGMTFFSSTMKPEQAVERYLADLQAVARQVSGRLKELQATA
>NZ_CP044549.1|WP_159595349.1|4669445_4669919_-|enoyl-CoA-hydratase
MPTPQPVAHRLFEDFQLNETWESPPTVVTAEEIVAFGHDFDPQPMHIDAAQAAQGPFKTLIASGWHVAAISWREFHRAGGYGGTPVVGLGVDELRWHRPVRAGDVITVHREVIELRRSGSSPTHGIVRTRVSVRTQNGETAMTLLTASRIPCREVHP
>NZ_CP044549.1|WP_159597037.1|4668984_4669416_-|MaoC-family-dehydratase
MAAYVGQPLGVSGWITLDQAKIDAFAELTGDDHWIHIDVERAAQEMPQGKTIVHGFLVLALIPFLQRSVFSIRQRGKGLNYGCNRVRFISPVPVGSRVRLRQSLQACVAVEGGTRFTFDCTVDIDGQERPALVAETLVQIFDR
>NZ_CP044549.1|WP_159595348.1|4667371_4668988_-|AMP-binding-protein
MSIPNAVPDTPAFVSFAQAIAAHAAAQPDHLAFQVDDRALSWRDFHEQVVQVARALAADGMGAGDKVALIGLSSLAYIECFFGAVAARACAVPLPASASVAALEAMVRDSGARLLFLDPDTGPAIAELAQRLASHGVVRVIPFGNAGSDGAAFAAWRAKGADSQQALPRAQADDAFNIIYSSGTTGVPKGIVHAHGMRQRQASRKGFAFSPTSRSLLSTPLYSNTTIMPMLGAVANGGACILMRKFDAGRFIAMATAHRATHTMLVPVQVQRILAHPDFAGSDLSALALSQTTGAPMDAALKREILARWPGRFLEVYGLTEGGVTCLLEMREHPDKLHTVGKAAPGTDVFLIDDAGQRLTPGESVTGEVVGRSPFMMVGYHHRPDADAQMRWFDAEGRVYHRSGDIGRFDADGFLTLLDRKKDVIISGGNNIYAADLEAVLAGHADVLEAAVIGVPSPQWGETPLALVVLQSGATLGADALRDWANSQLGKTQRLSAVELLPELPRNALGKLSKKELRAPYWHATSEIQTKTERQAAP
>NZ_CP044549.1|WP_159595347.1|4666601_4667375_-|SDR-family-oxidoreductase
MNNPSAKPVCVVTGSSSGIGAATALLFAQQGHNVVINYVKKAEPAQNMAEQCREAGADVLVVQGDVADDAQCRALADAVRHRWGRADVLVNNAGISTKFADIKDLDALSEHDFEATYRVNVIGAYQMSRALAPLLKAGPLSAIVNISSLAGRMGAGSSIAYACSKGALNTLTLALARSLAPQVRVNAILPGMIDGDWMRNGLGPEVFEQRRQRWESRALLNAVMSVQDVARTAHWLATGATKSTGQLIDIEAGFVLG
>NZ_CP044549.1|WP_159595346.1|4665486_4666479_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MNTTRILRPFSLALAIAAGAILSFQGAAQAQSPWPNKPVRIIASFAPGGSSDLVARQLALHLTQHYGQQFIVENRAGASGNIGVDFVAKAAPDGYILGLGTSGPLANNKALFTSMPFDPEKDLTPIALVGEIPLLISVNPSVKANNLAEFVALSKSSTDPLLMAHPGNGTIGHLAIEFLSVNGGGKFRSVPYKGDTPALADTLAGTVQAVSVPVTSQIQHVQAGKLKALAFTSKTRFAGLPNVPTANEQGVPLEATVWSAMVGPAGLSPAIVQSLNSEINKYTASAEGKAKLASLGMTALGGTPAQLQELMRSEAGKWKQVAQSAKISLD
>NZ_CP044549.1|WP_159595354.1|4679880_4680909_-|substrate-binding-domain-containing-protein
MSKVARIPDIAHMAGVSTATVDRVLNRRPGVRRATVERVMQAAERLQYLPDADVRAALQPPPMQLVFLLPAGSNRFLRMLGDTIGYSQEHCTPYNVQCKVEFVEGFNPEVLAKALLRHGARAQGIAFMALEHPLVRDAVDQLAERGVHTVTLISDLSGARRAAYVGLDNRAAGRTAAYLIARFIGERPAQVAMIAGSLSYRAHEEREMGFLYLFKESFPHIEVVGLREGHDDAERNHALTRTLLDQYPDLAGIYNIGGASDGVGRALKEAGRDQKVVFIGHGLSPDTRALLIDGTMDAVISQSPQGAMLTCVRIFANLRDGRDALTGVEAVRGQIMFRENLP
>NZ_CP044549.1|WP_159595355.1|4681133_4681823_+|ABC-transporter-permease-subunit
MTYEFDFASVLAAWPLFLEGAWMTIQLSFPATVLGFVIGTVLAIGRRSDVRWISRLCGAYVEVIRNTPLLVQVFLVFFGLASLGWKVSAFTAALVSLVINVAAYSCEIMRAGMDSIHKGQLEAAECLGLTKRQVYWHVVLRPAMEKVYPALTSQFVLLMLATSITSQISVEELTAIAARVQSETFRPFEAYILVAVGYLLLSLLMRAGLWVFGQLVFTRKRRLGAGSAK
>NZ_CP044549.1|WP_159595356.1|4681819_4682491_+|ABC-transporter-permease-subunit
MIDGGLNLFHLQFLGVGVLWTLCLSLIAFVGGGLAGGVVALCRISPMAPVRWLAIGWIQLIQGTPLLVVLFVCYFGLSIVGLELPGLVAASIAMVVYVSAYLGEIWRGCIESVPRTQWEAAECLALSRSQRMRLVVLPQALRIATPPTVGFMVQIVKNTSLASIVGFVELVRAGQLINNSIFQPFLVYLIIAALYFAMCFPLSVWSRRLERRLNVGSRIQGEA
>NZ_CP044549.1|WP_159597039.1|4682508_4683237_+|ATP-binding-cassette-domain-containing-protein
MTPVVELKDVHKRFGSNQVLKGVSFAIPKGQVVAIIGKSGSGKSTALRCIDRLEIIDSGSIQVCGHAVHDPAIDLRKLRMDVGIVFQSYNLFPHLTVEQNVTLAPKAVKGLSNADAKAVAERTLRQVGLAEKAQAYPEQLSGGQQQRVAIARSLAMEPQVMLFDEVTSALDPQLTGEVLRVIEQLAEGGMTMVLVTHEMEFAARVADTIIYMHEGKVWETGPGTMLREPQTPELREFLSHGL
>NZ_CP044549.1|WP_159595357.1|4683283_4684078_+|transporter-substrate-binding-domain-containing-protein
MNTSRILRRTVLAATLGALCLPAMADLADIKAAGKIRIAIDLSAPFYGYVDDKVNPAGSDVEAAQLLAKDLGVQLEIVNSTNSARIPNLLSNKADLIISSLSITPERQKAVDFSIPYGAIQAAVGAPKSLKITGIDDLAGKTVAVTRGGPQDKIVTERAPQAKVVRFDDEAASITAAASGQTDIVAITPPIIAAIAKRAPAKEFEVKFVLQSYQLAVAMRKNQPELMNWVNGWVKTNLSNGKLNAIHLKHAGVPIPKEIVDGAK
>NZ_CP044549.1|WP_159595358.1|4684116_4684659_+|VOC-family-protein
MSRHFGEIRQLGYVVHDIEAAMDYWSRTLGVGPWYYNPRVPIKNYQYDGQDYEPHNSVALANSGFVQVELIQTRNDVPSMYRDFLQAGRTGLQHVAYWTSDYDADLKRLLAEGFKPKMQGEVGERGRFIYFDTEYHPGTVIELSEVAGPKGRMFDLIRESSKTWDGVTEPVRPFPDLSKI
>NZ_CP044549.1|WP_159595359.1|4684660_4685935_+|ribulose-1,5-bisphosphate-carboxylase
MASERLHATYLIETPLEPAQVAEVMAGEQSCGTFTRVAGETDDLRERARATVEHIELLPDAPAPSLPNAWLERQGCTGPWRRARVRIAFPTANIGANLPTLAATVSGNLYDLGEVTGLRLESMQLPAAYRARFDMPQLGIAGTRQRTGVTSGALVGTIIKPNVGFSAAQTAELVAQLCAAGVDFIKDDEVCADPEHAPLAERVPAVMAVVREHQERTGKHVMVAFNITDETDAMRRHADLVEREGGSCVMASLNWCGYSAMQTLRRHTPLAIHGHRNGFGALARHPLLGIGFQAYQTLWRLAGVDHMHVHGLQGKFSQTDEEVVESARDCLAPLTDGHADAVMPAFSSGQWAGTVPATWSAVGTDDLMFMSGGGILAHPQGPAAGVASIRQAWAAARAGTPLAEAARQAPELAAALAFFGPKTK
>NZ_CP044549.1|WP_159595360.1|4685939_4687256_+|four-carbon-acid-sugar-kinase-family-protein
MNTPRLAWYGDDFTGATDTLATAAQAGLRSLLFLGVPSAAHLQAAGPLDAIGIAGAARAMDPQAMAAELEPVGRFFAALRAPVVHYKCCSTFDSAPHVGSIGQAVRVLNRHIGSAWVPIVGGQPNIGRYCCFSQLFASAGAQGEVHRIDRHPTMSRHPVTPMGEADLRRHLQAQGLARVAALHYPAHAQTADAHDAALQQLLATQPDAVLMDISGPQDLGPVGRLIWRRAQEAPLLVVGPSGVVQALAAHWHGAANPAPALPAPTPVDSPVFAFAGSLSPQTAAQVAAATSFQKIPVDVRRLLEEPDYASACCDAVLAGLAARRHVLAHTESHTRHADLDAHAIASATGDLVASVVRARAASAVPLRRVGIAGGDTSSLAVQRLGLWGLACQGVLAPGVTLSRARSDAPSLDGLELMLKGGQMGPLDMFERLLHGTVP
>NZ_CP044549.1|WP_159595361.1|4687259_4688858_-|inorganic-phosphate-transporter
MTKKSRRRFLIKHQEVLQLSVALLFLVVVGAYASLTGASSAGLSTSAIWLLIVAASVGAYMSMNIGANDVANNMGPAVGSGAMTMGWAILIAAVFEALGAIVAGGDVVGTIKGNIIDPRAISDPALFAWVMFSALLAGALWLNLATAVGAPVSTTHSIVGAVMGAGIAAGGWGLVNWGTIGQIVISWVVSPLAGGAIAAAFLYIIKRSVTYRSDMIEAAGRVVPILIALMVGVYTTYMLLKGLGQLVHVNVLQALVAGVVMALLVWVLIRKPIATMARRQDNSKKSVNRLFTWPLICSAALLSFAHGANDVANAIGPLAAIYEAVKDGAIATSAGTPMWIMVLGALGLAVGLALYGARLIRTVGKEITELDNMRAYAIAMSATLTVIVASQMGMPVSTTHISIGAVFGVGFLRELLKVNYAKMEAVVRKGHQGADRDVVEAYLSRFEAAEVSEKKRMLAELKQRARQREAVATDEDGAVFAKKEQKAFKKAYKKEIVKRSVVMRIVAAWIVTVPATAVLAAVLFYIVRAVLD
>NZ_CP044549.1|WP_159595362.1|4688934_4689540_-|oligoribonuclease
MTSSPPPASAAVETPSSDIPTLARSDQNLVWLDCEMSGLDPEKERLLEIAVVITGPQLTPRVEGPVIVLHQSDAVLNAMDAWNKGTHGRSGLIDKVKASTVDEEQATAELLAFIGRYVPKNSSPMCGNTISQDRRFLVKYMPKLEAYFHYRCLDVSTLKELAKRWRPEVYDAFKKHQRHTALADVHESIDELEHYRTHFLR

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Crispr_ID: NZ_CP044549_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044549_7

5098429-5098517

Orphan

Consensus_repeat	Method
GCCGTCCCTCGATGCCTCTGGATG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044549_7

>merge|NZ_CP044549|7|5098429-5098517|CRISPRCasFinder
GCCGTCCCTCGATGCCTCTGGATGCAGTCACGCGCGCCGGAGAGAGCTGGTGCCTCGGGCCGGCGGCCGTCCCTCGATGCCTCAGGATG

>NZ_CP044549|7|6|5098429-5098517|CRISPRCasFinder
GCCGTCCCTCGATGCCTCTGGATG	CAGTCACGCGCGCCGGAGAGAGCTGGTGCCTCGGGCCGGCG
GCCGTCCCTCGATGCCTCAGGATG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044549.1\|WP_159595705.1\|5094538_5096719_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044549.1\|WP_159595707.1\|5098618_5099461_+\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|235714
NZ_CP044549.1\|WP_159595700.1\|5090486_5091035_-\|glycine-zipper-2TM-domain-containing-protein	unknown	unknown	gnl\|CDD\|183072
NZ_CP044549.1\|WP_159595709.1\|5100012_5101077_+\|ornithine-cyclodeaminase	unknown	unknown	gnl\|CDD\|236064
NZ_CP044549.1\|WP_159595714.1\|5105529_5106555_+\|porin	unknown	unknown	gnl\|CDD\|238208
NZ_CP044549.1\|WP_159595708.1\|5099465_5099891_-\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_CP044549.1\|WP_159595702.1\|5092603_5093167_-\|DNA-deoxyinosine-glycosylase	unknown	unknown	gnl\|CDD\|381682
NZ_CP044549.1\|WP_159595716.1\|5107333_5108113_+\|RNA-polymerase-subunit-sigma-70	unknown	unknown	gnl\|CDD\|227648
NZ_CP044549.1\|WP_159595703.1\|5093163_5094006_-\|TatD-family-deoxyribonuclease	unknown	unknown	gnl\|CDD\|223162
NZ_CP044549.1\|WP_159595704.1\|5094100_5094526_+\|META-domain-containing-protein	unknown	unknown	gnl\|CDD\|377111
NZ_CP044549.1\|WP_159595715.1\|5106747_5107320_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|105710
NZ_CP044549.1\|WP_159595701.1\|5091235_5092222_-\|transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP044549.1\|WP_159597072.1\|5096787_5097972_+\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|176459
NZ_CP044549.1\|WP_159595712.1\|5103357_5104338_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP044549.1\|WP_159595713.1\|5104460_5105405_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP044549.1\|WP_159595710.1\|5101101_5102148_-\|low-specificity-L-threonine-aldolase	unknown	unknown	gnl\|CDD\|236710
NZ_CP044549.1\|WP_159595706.1\|5098067_5098340_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044549.1\|WP_159595711.1\|5102144_5103347_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|349916
NZ_CP044549.1\|WP_159595698.1\|5088938_5090066_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|293841
NZ_CP044549.1\|WP_159595699.1\|5090176_5090476_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP044549.1\|WP_159595707.1\|5098618_5099461_+\|enoyl-CoA-hydratase	gnl\|CDD\|235714	PRK06142, PRK06142, crotonase/enoyl-CoA hydratase family protein.	2.7705e-97
NZ_CP044549.1\|WP_159595700.1\|5090486_5091035_-\|glycine-zipper-2TM-domain-containing-protein	gnl\|CDD\|183072	PRK11280, PRK11280, hypothetical protein; Provisional.	2.08515e-60
NZ_CP044549.1\|WP_159595716.1\|5107333_5108113_+\|RNA-polymerase-subunit-sigma-70	gnl\|CDD\|227648	COG5343, COG5343, Uncharacterized protein conserved in bacteria [Function unknown].	5.09831e-40
NZ_CP044549.1\|WP_159595714.1\|5105529_5106555_+\|porin	gnl\|CDD\|238208	cd00342, gram_neg_porins, Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers are stabilized by hytrophillic clamping of Loop L2. Loop 3 bends into the pore, creating an elliptical constriction of about 7 x 11A, large enough to allow passage of a glucose molecule without steric hindrance. Removal of the C-terminal residue (usuallly F) destabilizes the trimer and removal of the 16th beta-sheet abolishes trimerization. Unlike typical membrane proteins, porins lack long hydrophobic stretches. Short turns are found at the smooth, periplasmic end, longer irregular loops are found at the rough, extracellular end. C-terminal residue forms salt bridge with N-terminus.	1.06016e-54
NZ_CP044549.1\|WP_159595702.1\|5092603_5093167_-\|DNA-deoxyinosine-glycosylase	gnl\|CDD\|381682	cd10032, UDG-F6_HDG, Uracil DNA glycosylase family 6, includes hypoxanthine-DNA glycosylase and similar proteins. Uracil DNA glycosylase family 6 hypoxanthine-DNA glycosylase (HDG) lacks any detectable UDG activity; it excises hypoxanthine, a deamination product of adenine, from double-stranded DNA. Uracil-DNA glycosylase (UDGs) initiates repair of uracils in DNA. Uracil in DNA can arise as a result of misincorporation of dUMP residues by DNA polymerase or via deamination of cytosine. Uracil in DNA mispaired with guanine is one of the major pro-mutagenic events, causing G:C->A:T mutations. Thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other.	8.58491e-63
NZ_CP044549.1\|WP_159595708.1\|5099465_5099891_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	2.76284e-28
NZ_CP044549.1\|WP_159595709.1\|5100012_5101077_+\|ornithine-cyclodeaminase	gnl\|CDD\|236064	PRK07589, PRK07589, ornithine cyclodeaminase; Validated.	0
NZ_CP044549.1\|WP_159595704.1\|5094100_5094526_+\|META-domain-containing-protein	gnl\|CDD\|377111	pfam03724, META, META domain. Small domain family found in proteins of of unknown function. Some are secreted and implicated in motility in bacteria. Also occurs in Leishmania spp. as an essential gene. Over-expression in L.amazonensis increases virulence. A pair of cysteine residues show correlated conservation, suggesting that they form a disulphide bond.	6.96312e-34
NZ_CP044549.1\|WP_159595715.1\|5106747_5107320_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|105710	PRK12514, PRK12514, RNA polymerase sigma factor; Provisional.	1.6427e-37
NZ_CP044549.1\|WP_159595698.1\|5088938_5090066_-\|hypothetical-protein	gnl\|CDD\|293841	cd16283, RomA-like_MBL-fold, Enterobacter cloacae RomA and related proteins; MBL-fold metallo hydrolase domain. Derepression of the romA-ramA locus results in a multidrug-resistance phenotype. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	4.55065e-67
NZ_CP044549.1\|WP_159595710.1\|5101101_5102148_-\|low-specificity-L-threonine-aldolase	gnl\|CDD\|236710	PRK10534, PRK10534, L-threonine aldolase; Provisional.	3.53809e-125
NZ_CP044549.1\|WP_159597072.1\|5096787_5097972_+\|DNA-polymerase-IV	gnl\|CDD\|176459	cd03586, PolY_Pol_IV_kappa, DNA Polymerase IV/Kappa. Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.	1.09195e-126
NZ_CP044549.1\|WP_159595712.1\|5103357_5104338_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	1.61766e-108
NZ_CP044549.1\|WP_159595713.1\|5104460_5105405_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.224e-32
NZ_CP044549.1\|WP_159595701.1\|5091235_5092222_-\|transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	2.1316e-23
NZ_CP044549.1\|WP_159595711.1\|5102144_5103347_-\|amidohydrolase	gnl\|CDD\|349916	cd05666, M20_Acy1-like, M20 Peptidase aminoacylase 1 subfamily. Peptidase M20 family, uncharacterized subfamily of bacterial proteins predicted as putative amidohydrolases or hippurate hydrolases. These are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. Aminoacylase 1 (ACY1) breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	0
NZ_CP044549.1\|WP_159595703.1\|5093163_5094006_-\|TatD-family-deoxyribonuclease	gnl\|CDD\|223162	COG0084, TatD, Mg-dependent DNase [DNA replication, recombination, and repair].	1.44856e-78

>NZ_CP044549.1|WP_159595706.1|5098067_5098340_+|hypothetical-protein
MFFCLNLAELERIKRWHVAHRQEHPLEYQLWDAVLTVWVMGWVGWVPAFYSHALWLVPLCVFGINMPGLYVRWRRKVHAAHRLRCDWLDE
>NZ_CP044549.1|WP_159597072.1|5096787_5097972_+|DNA-polymerase-IV
MDAFFASVELLRYPQLKGLPVVIGGGRRREDAMLARLREVYPERAWTDEDSAHIPVEFFPRLESYVGRGVATTATYPARQFGVGSAMGLMKAAKLCPQAILLPVDFDEVRRISRLFKSTIREIAPVVEDRGVDEVYIDFTDVAGGQREGGRVLARLIQKSIHQATGLTCSIGVAPNKLIAKMASEFQKPNGISIVHIEDLERLIWPLPCRKINGVGPKADAKLQGHGIHTIGELAQRERHWLVEHFGKSYGAWLHDVARGRDDRPVQTESEPVSMSRETTFERDLHAVRDRAELGAILTQLCEQVADDLQRKGYVGKTIGVKLRYDNFQIVTRDTTIDHYTHDPASVRRQAGLCLKRVDLTRRIRLLGVRVGTLAKVGEVPLEPERLPDTAPLF
>NZ_CP044549.1|WP_159595705.1|5094538_5096719_+|hypothetical-protein
MLGSLQQFAVALVGAVGVFLLGKLLIAGGHRAFEPALAWIRPVLLRIDHALAMPLARWIGLDENRAWRRWSRLLGTLCALGFVGAVAPWPLGVIALSLGLLAVLAVFRRWAWDENDRELGLPSEDRRFRNGEDYGDEALAALAAVVMLSSLLVWRLTGVHAFEGPVAEGEPGYLLHILSETLAALPIIGNVDVLGYEDPSGVRVLQPNGGPVAFALRMAIDLVVIGGLLKAVDIARRMARGQDLRREEEALASRDLARVLPSIHRLRRLAVGGDANAMNLLASAAASPAAGQAPRARLCAVHALRSAAEQHPEWAGTILLDNRLACAAVLADPATADADLLGAAHLENAENALAEARMSQDHVAAKLIGSAIAGLSQAVMAQGLTPLPEAFLLDRPPQTSMPARSALVLRLAELKLRLTEHVHTDSAAEILQEALGHVQTVLAHLPAEATPDARLRVHQCHAQILARLGERDPSYEGSVLLTDALDAFAHAQTLVDDGDALARIGLWTGRGVVHEILGHRTEGPPSVAHFAEAAQLFDAAATLMVDAQVGTADAAQCFINLGNACGAAAQATESVAIDDDQATPVQAWLDRAVQAYSNGLRLVGAGHWPGLAHNAFHGLAAAHEHRFSRMGERHDIEAAIGARLSILDEIDPRQAPAEWARAAIELSQAEHLALPSSASTSIGHSAVDRLRQARERLAQAGDEEALQRCDALMEAIRADVAARDRG
>NZ_CP044549.1|WP_159595704.1|5094100_5094526_+|META-domain-containing-protein
MSHTTRLAWIVAPALLVLNACALPGASAPAPLVGSEWLLEDLGGRGVLDRVQATLAFPEAGRVAGNSSCNRFFGSYTLMQDKVAFGQLGGTRMACPPAVGDQEARYLDALQKAQRLEVQGKTMLMHVQGLDKPLRFTRTQP
>NZ_CP044549.1|WP_159595703.1|5093163_5094006_-|TatD-family-deoxyribonuclease
MWIDTHCHLDAPEFGADHALTFEARQRASERGVGLCVIPAVMRANFDTVRTLAHRLGDAYALGIHPLCVPQAGDDDLAALDAALTAHRDDPRLVAVGEIGLDFFVPALCTPEMRERQAFFYRAQLRLARRHGLPVIVHVRRSADHLLKHLRELPVAGIAHAFNGSEQQARSFLDMGFKLGFGGACTFDAARQLRRLAAGLPLSALVLETDAPDMAPQWLYVTVQARAGGRAQGINTPAELPRIGAVVADLRGSPVEELMRATTSNALAALPRLAALEAVS
>NZ_CP044549.1|WP_159595702.1|5092603_5093167_-|DNA-deoxyinosine-glycosylase
MSAAPGRPKQARTAARSAEGCLVSRLQGLAPVLSADTRVLVLGSFPGVASLRSQQYYGHPQNHFWKILGALWNLPLSTMGYEDRVNALQTHGLGVWDVYGACEREGSLDADIRNAALNDFSVVRWQCPKLGAIVHNGSESFRHAHHTEMLGVPVYKLPSTSPANASWSFDRKLAAWGEILRQHGVAD
>NZ_CP044549.1|WP_159595701.1|5091235_5092222_-|transposase
MTSSLGVDVSKAKLDVALLNDEGKYRCKVFANSGMGFAALHQWLQTHLPQGQELAALHVCMEATGSYHEPLALHLHDLGVRVSVVNPLRVKRFIELEGTGNKTDQGDSKSLARFCRMASPELWEAPAPGVRALQALVARLDALQEMRQSEANRLEVAHGVVQASLHEMLATLDKTIAQVKAQIRQTIDDDPHLRGRAQLLHSIPGLGDRTIPQLLAYIGRPERFKSVKALIAYASLSPAIRQSGTSLNKRGGTHAQGHRQLKHALYFPAMVAGRHNPAVAAFWQRLKAQNKPGKVIVVACMHKLLAIVYGVLKSRTPFDATRFCDANT
>NZ_CP044549.1|WP_159595700.1|5090486_5091035_-|glycine-zipper-2TM-domain-containing-protein
MDKSMMKGLVVGGLATVVIGASGVTGYQALMKPKEAEVVAVKDVMQTVVTPVEHCENVAVNRQAPVKDQHRIAGSVIGGVAGGLLGSTIGGGNGKTLATVAGAAAGGYAGNQVQKNMQQKDVITTTERRCRTVNQKSQKLNGYQVTYRLDGREETVRTSFKPGPTLPVKDGQVVTTPPTPGG
>NZ_CP044549.1|WP_159595699.1|5090176_5090476_+|hypothetical-protein
MQYSLSHHKLKLILAAQGLKTGDAGGIDQLFGGKDGYYWYGTLRDLCPEGKTLSWENQYAMVAAIQAHENATAEEDEMKPQVPSAANIAAISKLLADPI
>NZ_CP044549.1|WP_159595698.1|5088938_5090066_-|hypothetical-protein
MNSFGKRAQGLRLERMQASPRWDGMGFRNLHPVLPGLRDPTAAKPTLKDFFSSGGRRTPAGPLPLVDPREAWRRPIASGLRATWLGHSTVLVEIDGHRVLTDPVWGARASPFRLVGPKRFQPMPLRLRHMPEVDVVMISHDHYDHLDYPTIHTLARHSAVPFVTSLGVGAHLEAWGVAPERITELDWWESHRVPGTGLTITAAPSQHFSGRGLKDRNATLWSSMVVNTDRHRVFFSGDTGLTTEYGLIRERLGPFDLVMLEVGAFHPSWGDIHLGPANALKAHALLGGGAFLPVHWGTFGLAMHDWDEPVETLLQLAGAQDTALLLPRLGEAVEPALQRPVAPWWRATGLGSSAPERAAPTPVSTPTRELPWPLD
>NZ_CP044549.1|WP_159595707.1|5098618_5099461_+|enoyl-CoA-hydratase
MTAPTCFSLTTTDHIAHLVLNRPAELNTMHPTFWRELDELLTQLHHEGSARALVISSTGKHFSAGMALETFAGAISMDDQSPEGRAAIFDLLTDMQATFTKIENLRIPVICAIQGGCIGGAVDMVTAACIRYASADAFFCIQEINIGMVADVGTLQRLPKLVPFAVVKELAYTGRRLPAARAMAYGLVNEVFDNAEATLAAALQCAQEIASKPPVAIWGTKQAVTYARDHTVEDSLRQMGWLQGAIWSNAHVRESIAAMKEKRAGDFTPLSALKPFTALG
>NZ_CP044549.1|WP_159595708.1|5099465_5099891_-|winged-helix-turn-helix-transcriptional-regulator
MDALDQRLIALLRKDARTNVAALAKALGLSRGTVNNRIARLEDEGMIVGYTVRLRPDAQPHEIGAWMSVAVEGNQTRAVIASLLGEPGVAALHDTNGRWDLLAELRASSLSELSQVLERIRLIRGISSTETSLHLATYRLS
>NZ_CP044549.1|WP_159595709.1|5100012_5101077_+|ornithine-cyclodeaminase
MNTPALPTLFLSAQDVATLVHRIGLPTVLERMADTVHADYLRWPAFDKSARVAHHSSDGVIELMPIADDTTYAFKYVNGHPRNTRAGLPTVMAFGVLADVATGAPVLLSELTLTTALRTAAMSVVAARALARPDSLRMALIGNGAQSEFQALAFHHLMGIDEIRLFDTDAAATRKLMANLGHEPGLRLIACDSVAQAVCGADVVTTVTADKTNATILTPEMIEPGMHINGVGGDCPGKTELHPDVLRKASVFVEYEPQTRIEGDLQHLPADFAVTELWQVLAGQAAGRTGAAQVTLFDSVGFALEDYSALRFLREAASELGLGHALPLIPALADPKDLFGLLRQRTPRKLALAA
>NZ_CP044549.1|WP_159595710.1|5101101_5102148_-|low-specificity-L-threonine-aldolase
MNPIIDLRSDTLTQPTPAMRDAMARAPLGDDGYGEDPTVNALQDKVAALLGFEAALFMPTGTQANLCAILAHCGRGDEYIVGQQAHCYRWEGGGAAMLGGVQPQPLEHEADGRIGLAGIADAVKPPGDHCPTSRLLALENTLGGKVLPEPYLDAACALAAQQGLSTHLDGARLFNAAVYEAQTLGLTPLAQARRIAGHFDSVAVCFSKGLGAPAGSALCGSAAFIARARRLRRTLGGTMRQTGVLAAAALFALDHHVSRLAEDHRLAQRLHAGLAGLDGLHVEAPMTNVLFLELRGGHADKTPQLIDHLRQRSVWVSGQYRLRLVTHMDVDASSAERVVGAFREFLDA
>NZ_CP044549.1|WP_159595711.1|5102144_5103347_-|amidohydrolase
MSTLLNVAQQGLDEIIAIRRDIHAHPELGFEETRTAAVIAEKLRSWGVEVTEGIATTGVVGTVRGRRAGARSIGLRADMDALSIGESNALAHASKVPGRMHACGHDGHTAMLLGAARALAENPDFEGTVHLIFQPAEEALGGAPAMLQEQLFERFPCDRIFGMHSYPALPVGSFGTRPKEMMAASGRFRVVFKGSGGHGGEGPHRSNDLSVVAAHFILGLQSIVSRNLAPTESAVVSVGHLGAGDAKALSVMPAELTIAGTMRAFNPQTQTLLETRIRAHAETYAQSEGATAEVTCWWLCVPLFNTPDATLTAVSAATDVVGPQAVQDDLPRITAGDDFAYMLHQRPGAYMLIGNGRHDGDGGGNVHSPHYDFNDKVLPYGIAYWLSLVNQELGGRLGRA
>NZ_CP044549.1|WP_159595712.1|5103357_5104338_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MNRVRLAIFLALLGLAAASSQAATPAPYPSKPVTLIVPFPAGGSADVIARVINVPLGNQLGQPVVVENVGGAGGGLGAARLARAPADGYTVLLGTVNEVVVVPLVNRTVPYKVDDLVPVGKVGESSLVLVGRKDIPARNTDELVEYARSNPGKLTYATSGIGSMQHVIMEMVQARTGASMLHVPYRGGSSLISDVLGGQVDLAIVTPAAAADHIEAGRLRAFGTTSLRRDESLKRVPTLNEGQYLKDLQQNVWIGLFVPVNTPSDVATRLNAALTALLADEGVRSQLQRASLSPAARAEQAGFSAKVAEDRAQMRETVSKMKLSKD
>NZ_CP044549.1|WP_159595713.1|5104460_5105405_-|LysR-family-transcriptional-regulator
MVSSPSVLFARLMAGARFRHLQAFAAVAEFSSASRAATAIGMTQPAVTHLIADLEQLLECDLFHRHARGMRTTDMARELLPFVRRALTALEGGAEFVAHRHLNAHSVVRVGAIHGAISGLLVRASPVFSRAKPDILIDLQEVDGTGGQSALMAHREVDMLLCRQPDVIPEGWDYAELMQDRLVVVAGPAHPLVGRRGLRLPKVLQETWLLLPSSTNAIRVLEEMMVAHGIVARFARLRTRSPSMTLTQLRSEHLLMLAPYSVVRQQVDLGLLVILPVQEPMPYAPLGVLHAGEDLGPAARTFLEFLRRYAKQHA
>NZ_CP044549.1|WP_159595714.1|5105529_5106555_+|porin
MKKTLSTFAVSATFCAAAAAQSSVTLFGVVDLNLRAVDNARAGSLTTVSSSGMGSSVLGFRGTEDLGGGLQASFWIETGFFPDTGASASATKFWNRRTTLGLKSTRWGELRMGRDYTATFWNMPTYDPFSTNGVGASFNILPTPNIVPVATLTRADNMLAYYLPGNLGGVDGMLQYAFGEGDDDNKYAGGRLGYAAGPLSTAIAYGKTWTRTSTHVHLTDWGASWKFSAATLMGQIIHVRYGRYARTNYLVGATIPVGANAIRVSYLTSRFKGPTAIADDAQQFAIGYVHNLSRRTVLYTTASVLSNGRNGRFVLPSGPAVTAAHNGLQSKGVEFGMRHTF
>NZ_CP044549.1|WP_159595715.1|5106747_5107320_+|sigma-70-family-RNA-polymerase-sigma-factor
MSDHPDDALIALIDRVALRDEKALKALYDAVSSKLYGLSLRVVGKPEWAEDVLQETFLQIWRSAGDYRASLSPPMAWLGLIVRSRSLDFLRRRSAERTHLTDEIDEAMADTMAGDAPNPMDVSLASQQAWALHQCLGRLESRQREVVSLAYLRDLSHGELASQLKLPLGTVKTWIRRGLDQLRTCMAHFA
>NZ_CP044549.1|WP_159595716.1|5107333_5108113_+|RNA-polymerase-subunit-sigma-70
MNLIQHPELLDRLAAAHALGTLRGGARRRFEAMAREQAPVRAAALVWQSRVASMNELQAPAEPAPAVWTRIENLVHADQQQQAMASARSRPAPPRSGGWLRSLALWRGATAAGALATVLAVVTAVGLRDNLGARIGELQAQLDTAPQVQYVAVLHDDNARASMLVTFDPKHNQLTLQRVSGFQEASDKSLQLWALPPSGGPRSLGVLSHERLLQLTAGEGDVHEVPTLAVTLEPKGGVPVGSGPTGPVLFKGALIQKML

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP044549_2	2.1\|1598473\|54\|NZ_CP044549\|CRT	1598473-1598526	54	NZ_CP044549.1	1598773-1598826	0	1.0
NZ_CP044549_2	2.1\|1598473\|54\|NZ_CP044549\|CRT	1598473-1598526	54	NZ_CP044549.1	1598785-1598838	0	1.0
NZ_CP044549_2	2.2\|1598545\|66\|NZ_CP044549\|CRT	1598545-1598610	66	NZ_CP044549.1	1598761-1598826	6	0.909
NZ_CP044549_2	2.2\|1598545\|66\|NZ_CP044549\|CRT	1598545-1598610	66	NZ_CP044549.1	1598773-1598838	6	0.909
NZ_CP044549_2	2.3\|1598629\|54\|NZ_CP044549\|CRT	1598629-1598682	54	NZ_CP044549.1	1598773-1598826	0	1.0
NZ_CP044549_2	2.3\|1598629\|54\|NZ_CP044549\|CRT	1598629-1598682	54	NZ_CP044549.1	1598785-1598838	0	1.0
NZ_CP044549_2	2.4\|1598701\|18\|NZ_CP044549\|CRT	1598701-1598718	18	NZ_CP044549.1	1598809-1598826	0	1.0
NZ_CP044549_2	2.4\|1598701\|18\|NZ_CP044549\|CRT	1598701-1598718	18	NZ_CP044549.1	1598821-1598838	0	1.0
NZ_CP044549_2	2.5\|1598737\|30\|NZ_CP044549\|CRT	1598737-1598766	30	NZ_CP044549.1	1598797-1598826	1	0.967
NZ_CP044549_2	2.5\|1598737\|30\|NZ_CP044549\|CRT	1598737-1598766	30	NZ_CP044549.1	1598809-1598838	1	0.967
NZ_CP044549_2	2.6\|1598785\|18\|NZ_CP044549\|CRT	1598785-1598802	18	NZ_CP044549.1	1598809-1598826	0	1.0
NZ_CP044549_2	2.6\|1598785\|18\|NZ_CP044549\|CRT	1598785-1598802	18	NZ_CP044549.1	1598821-1598838	0	1.0

1. spacer 2.1|1598473|54|NZ_CP044549|CRT matches to position: 1598773-1598826, mismatch: 0, identity: 1.0

gggggaaccgcagggggaaccgcagggggaaccgcagggggaaccgcaggggga	CRISPR spacer
gggggaaccgcagggggaaccgcagggggaaccgcagggggaaccgcaggggga	Protospacer
******************************************************

2. spacer 2.1|1598473|54|NZ_CP044549|CRT matches to position: 1598785-1598838, mismatch: 0, identity: 1.0

gggggaaccgcagggggaaccgcagggggaaccgcagggggaaccgcaggggga	CRISPR spacer
gggggaaccgcagggggaaccgcagggggaaccgcagggggaaccgcaggggga	Protospacer
******************************************************

3. spacer 2.2|1598545|66|NZ_CP044549|CRT matches to position: 1598761-1598826, mismatch: 6, identity: 0.909

gggggaaccgcagggggaaccgcagggggaaccgcagggggaaccgcagggggaaccgca	CRISPR spacer
gggggaaccgcagggggaaccgcagggggaaccgcagggggaaccgcagggggaaccgca	Protospacer
************************************************************

4. spacer 2.2|1598545|66|NZ_CP044549|CRT matches to position: 1598773-1598838, mismatch: 6, identity: 0.909

gggggaaccgcagggggaaccgcagggggaaccgcagggggaaccgcagggggaaccgca	CRISPR spacer
gggggaaccgcagggggaaccgcagggggaaccgcagggggaaccgcagggggaaccgca	Protospacer
************************************************************

5. spacer 2.3|1598629|54|NZ_CP044549|CRT matches to position: 1598773-1598826, mismatch: 0, identity: 1.0

gggggaaccgcagggggaaccgcagggggaaccgcagggggaaccgcaggggga	CRISPR spacer
gggggaaccgcagggggaaccgcagggggaaccgcagggggaaccgcaggggga	Protospacer
******************************************************

6. spacer 2.3|1598629|54|NZ_CP044549|CRT matches to position: 1598785-1598838, mismatch: 0, identity: 1.0

gggggaaccgcagggggaaccgcagggggaaccgcagggggaaccgcaggggga	CRISPR spacer
gggggaaccgcagggggaaccgcagggggaaccgcagggggaaccgcaggggga	Protospacer
******************************************************

7. spacer 2.4|1598701|18|NZ_CP044549|CRT matches to position: 1598809-1598826, mismatch: 0, identity: 1.0

gggggaaccgcaggggga	CRISPR spacer
gggggaaccgcaggggga	Protospacer
******************

8. spacer 2.4|1598701|18|NZ_CP044549|CRT matches to position: 1598821-1598838, mismatch: 0, identity: 1.0

gggggaaccgcaggggga	CRISPR spacer
gggggaaccgcaggggga	Protospacer
******************

9. spacer 2.5|1598737|30|NZ_CP044549|CRT matches to position: 1598797-1598826, mismatch: 1, identity: 0.967

gggggaaccgcagggggaatcgcaggggga	CRISPR spacer
gggggaaccgcagggggaaccgcaggggga	Protospacer
*******************.**********

10. spacer 2.5|1598737|30|NZ_CP044549|CRT matches to position: 1598809-1598838, mismatch: 1, identity: 0.967

gggggaaccgcagggggaatcgcaggggga	CRISPR spacer
gggggaaccgcagggggaaccgcaggggga	Protospacer
*******************.**********

11. spacer 2.6|1598785|18|NZ_CP044549|CRT matches to position: 1598809-1598826, mismatch: 0, identity: 1.0

gggggaaccgcaggggga	CRISPR spacer
gggggaaccgcaggggga	Protospacer
******************

12. spacer 2.6|1598785|18|NZ_CP044549|CRT matches to position: 1598821-1598838, mismatch: 0, identity: 1.0

gggggaaccgcaggggga	CRISPR spacer
gggggaaccgcaggggga	Protospacer
******************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP044549_1	1.1\|1245778\|27\|NZ_CP044549\|CRISPRCasFinder	1245778-1245804	27	NZ_CP035092	Paracoccus denitrificans strain ATCC 19367 plasmid unnamed1, complete sequence	147412-147438	5	0.815
NZ_CP044549_1	1.1\|1245778\|27\|NZ_CP044549\|CRISPRCasFinder	1245778-1245804	27	NC_008688	Paracoccus denitrificans PD1222 plasmid 1, complete sequence	394759-394785	5	0.815

1. spacer 1.1|1245778|27|NZ_CP044549|CRISPRCasFinder matches to NZ_CP035092 (Paracoccus denitrificans strain ATCC 19367 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.815

caaatcgaatgcatctgcgcagcgacc	CRISPR spacer
tggatcgaatgcatctgcgccgcgatc	Protospacer
...***************** ****.*

2. spacer 1.1|1245778|27|NZ_CP044549|CRISPRCasFinder matches to NC_008688 (Paracoccus denitrificans PD1222 plasmid 1, complete sequence) position: , mismatch: 5, identity: 0.815

caaatcgaatgcatctgcgcagcgacc	CRISPR spacer
tggatcgaatgcatctgcgccgcgatc	Protospacer
...***************** ****.*

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

476910 : 483763

Enterobacteria_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_159588943.1\|476910_477600_-	pseudaminic acid cytidylyltransferase	A0A1B1IVD3	uncultured_Mediterranean_phage	1.0e-09	32.9
WP_159596782.1\|477625_478717_-	aminotransferase	E5ES42	Bathycoccus_sp._RCC1105_virus	1.4e-42	30.0
WP_159588945.1\|478727_479096_-	hypothetical protein	NA	NA	NA	NA
WP_159588947.1\|479105_480284_-	UDP-4-amino-4, 6-dideoxy-N-acetyl-beta-L-altrosamine transaminase	A0A2D2W2B8	Stenotrophomonas_phage	1.2e-15	28.8
WP_159588949.1\|480333_480888_-	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	2.3e-49	54.5
WP_159588951.1\|480884_481778_-	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	1.5e-98	59.6
WP_159588953.1\|481796_482696_-	dTDP-4-dehydrorhamnose reductase	A0A140G5S3	Enterobacteria_phage	1.3e-20	32.0
WP_159588956.1\|482692_483763_-	dTDP-glucose 4,6-dehydratase	A0A1D7XFE8	Escherichia_phage	7.1e-87	48.8

DBSCAN-SWA_2

1499798 : 1545501

Leptospira_phage(40.0%)

transposase,integrase

attL 1500307:1500366|attR 1528376:1528668

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_159590746.1\|1499798_1499993_+\|transposase	IS3 family transposase	NA	NA	NA	NA
1500307:1500366	attL	NA	NA	NA	NA
WP_159590482.1\|1500637_1501725_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	7.1e-42	36.7
WP_159590748.1\|1503750_1504389_-	flavin reductase family protein	NA	NA	NA	NA
WP_159590750.1\|1504750_1505503_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_159590752.1\|1505499_1506645_+	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_159590754.1\|1506648_1507137_+	acyl dehydratase	NA	NA	NA	NA
WP_159590756.1\|1507143_1509288_+	CoA-binding protein	NA	NA	NA	NA
WP_159590758.1\|1509281_1510049_+	citryl-CoA lyase	NA	NA	NA	NA
WP_159590760.1\|1510201_1510942_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_159590762.1\|1511173_1512721_-	acetolactate synthase large subunit	G9E4W7	Ostreococcus_lucimarinus_virus	1.1e-08	30.9
WP_159590764.1\|1513003_1513885_+	tripartite tricarboxylate transporter substrate binding protein	NA	NA	NA	NA
WP_159590766.1\|1513895_1515020_+	mandelate racemase/muconate lactonizing enzyme family protein	NA	NA	NA	NA
WP_159590768.1\|1515335_1516124_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_159590770.1\|1516144_1517317_-	alpha-hydroxy-acid oxidizing protein	NA	NA	NA	NA
WP_159590772.1\|1517319_1518111_-	tripartite tricarboxylate transporter substrate binding protein	NA	NA	NA	NA
WP_159590774.1\|1518432_1519872_+	aldehyde dehydrogenase family protein	NA	NA	NA	NA
WP_159590776.1\|1521270_1523439_-	prepilin peptidase	V5LQX0	Emiliania_huxleyi_virus	8.1e-05	49.2
WP_159590777.1\|1523456_1524626_-\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_159590778.1\|1524983_1525835_+	hypothetical protein	NA	NA	NA	NA
WP_159590779.1\|1526432_1527626_-\|transposase	IS91 family transposase	NA	NA	NA	NA
WP_159596851.1\|1527633_1528347_-\|integrase	tyrosine-type recombinase/integrase	S5W9T9	Leptospira_phage	5.3e-22	32.1
WP_159590780.1\|1529149_1531255_+	hydantoinase/oxoprolinase family protein	NA	NA	NA	NA
1528376:1528668	attR	NA	NA	NA	NA
WP_159590781.1\|1531251_1532979_+	hydantoinase B/oxoprolinase family protein	NA	NA	NA	NA
WP_159590782.1\|1532989_1533955_+	tripartite tricarboxylate transporter substrate binding protein	NA	NA	NA	NA
WP_159590783.1\|1533965_1535357_+	hypothetical protein	NA	NA	NA	NA
WP_159590784.1\|1535378_1536302_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_159590785.1\|1536532_1537468_+	hypothetical protein	NA	NA	NA	NA
WP_159590787.1\|1537516_1538992_+	FAD-binding protein	NA	NA	NA	NA
WP_159590788.1\|1539000_1540404_+	hypothetical protein	NA	NA	NA	NA
WP_159590790.1\|1540413_1541799_+	MmgE/PrpD family protein	NA	NA	NA	NA
WP_159590792.1\|1541979_1542840_+	carboxyvinyl-carboxyphosphonate phosphorylmutase	NA	NA	NA	NA
WP_159590794.1\|1543164_1544523_+	aminotransferase class III-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_159590796.1\|1544661_1545501_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	3.5e-81	56.2

DBSCAN-SWA_3

2036417 : 2094369

uncultured_Mediterranean_phage(50.0%)

tail,tRNA,protease,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_159596881.1\|2036417_2037203_-\|tRNA	tRNA pseudouridine(38-40) synthase TruA	NA	NA	NA	NA
WP_159592033.1\|2037265_2039896_-	fimbrial protein FimV	NA	NA	NA	NA
WP_159592036.1\|2040148_2041276_-	aspartate-semialdehyde dehydrogenase	NA	NA	NA	NA
WP_159592039.1\|2041353_2042439_-	3-isopropylmalate dehydrogenase	NA	NA	NA	NA
WP_159592042.1\|2042561_2043209_-	3-isopropylmalate dehydratase small subunit	NA	NA	NA	NA
WP_159592045.1\|2043224_2043386_-	entericidin EcnAB	NA	NA	NA	NA
WP_159592048.1\|2043425_2044847_-	3-isopropylmalate dehydratase large subunit	NA	NA	NA	NA
WP_159592051.1\|2044875_2045802_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_159592054.1\|2045983_2047279_-	citrate (Si)-synthase	NA	NA	NA	NA
WP_159592057.1\|2047275_2047593_-	succinate dehydrogenase assembly factor 2	NA	NA	NA	NA
WP_159592060.1\|2047615_2048320_-	succinate dehydrogenase iron-sulfur subunit	NA	NA	NA	NA
WP_159592063.1\|2048423_2050229_-	succinate dehydrogenase flavoprotein subunit	NA	NA	NA	NA
WP_159592066.1\|2050233_2050599_-	succinate dehydrogenase, hydrophobic membrane anchor protein	NA	NA	NA	NA
WP_159592069.1\|2050651_2051083_-	succinate dehydrogenase, cytochrome b556 subunit	NA	NA	NA	NA
WP_159592072.1\|2051237_2052038_-	UTRA domain-containing protein	NA	NA	NA	NA
WP_159592075.1\|2052254_2053241_+	malate dehydrogenase	NA	NA	NA	NA
WP_159596882.1\|2053330_2054239_+	CoA ester lyase	NA	NA	NA	NA
WP_159592078.1\|2054300_2056904_+	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase	NA	NA	NA	NA
WP_159592081.1\|2057054_2057864_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_159592084.1\|2057999_2058410_+	hypothetical protein	NA	NA	NA	NA
WP_159592087.1\|2058532_2058691_+	DUF3309 family protein	NA	NA	NA	NA
WP_159592090.1\|2058795_2061663_+	aconitate hydratase AcnA	NA	NA	NA	NA
WP_159592093.1\|2061715_2062627_+\|protease	trypsin-like serine protease	A0A1B1IRD3	uncultured_Mediterranean_phage	4.3e-08	29.1
WP_159592096.1\|2062656_2063658_+	AAA domain-containing protein	NA	NA	NA	NA
WP_159596883.1\|2063660_2064737_+	DUF58 domain-containing protein	NA	NA	NA	NA
WP_159596884.1\|2064760_2065813_+	VWA domain-containing protein	NA	NA	NA	NA
WP_159592099.1\|2065932_2069520_+	hypothetical protein	NA	NA	NA	NA
WP_159592102.1\|2069638_2070094_+	hypothetical protein	NA	NA	NA	NA
WP_159592105.1\|2070151_2072257_+	hypothetical protein	NA	NA	NA	NA
WP_159592108.1\|2072307_2073540_+	NAD(P)-binding protein	NA	NA	NA	NA
WP_159592111.1\|2073581_2074592_+	tripartite tricarboxylate transporter substrate binding protein	NA	NA	NA	NA
WP_159592114.1\|2074615_2080225_-	hypothetical protein	NA	NA	NA	NA
WP_159592117.1\|2081651_2081837_-	hypothetical protein	NA	NA	NA	NA
WP_159592120.1\|2082492_2082951_-	hypothetical protein	NA	NA	NA	NA
WP_159592123.1\|2083324_2083915_+	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_159592126.1\|2083911_2084733_+	hypothetical protein	NA	NA	NA	NA
WP_159592129.1\|2084802_2086572_+\|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	6.8e-50	28.5
WP_159592132.1\|2086603_2087047_+\|tail	phage tail protein	NA	NA	NA	NA
WP_159592135.1\|2087066_2088692_+\|tail	phage tail protein	NA	NA	NA	NA
WP_159592138.1\|2088691_2089330_+\|tail	phage tail protein	NA	NA	NA	NA
WP_159592141.1\|2089333_2090338_+	hypothetical protein	NA	NA	NA	NA
WP_159592144.1\|2090365_2090539_+	hypothetical protein	NA	NA	NA	NA
WP_159592147.1\|2090552_2091644_+	hypothetical protein	NA	NA	NA	NA
WP_159592150.1\|2091640_2092327_+	type IV secretion protein Rhs	NA	NA	NA	NA
WP_159592153.1\|2092333_2093983_+	hypothetical protein	NA	NA	NA	NA
WP_159592156.1\|2093979_2094369_+\|plate	baseplate assembly protein	NA	NA	NA	NA

DBSCAN-SWA_4

4564843 : 4624580

Escherichia_phage(22.22%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_159590796.1\|4564843_4565683_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	3.5e-81	56.2
WP_159595278.1\|4565694_4565979_-\|transposase	transposase	NA	NA	NA	NA
WP_159595279.1\|4566109_4567159_+	NAD-dependent epimerase/dehydratase family protein	NA	NA	NA	NA
WP_159595280.1\|4567444_4568284_-	response regulator	NA	NA	NA	NA
WP_159595281.1\|4568283_4572357_-	PAS domain-containing protein	A0A1V0SGX0	Hokovirus	1.7e-40	40.9
WP_159595282.1\|4573295_4575185_+	cold shock domain-containing protein	NA	NA	NA	NA
WP_159597034.1\|4575372_4575747_+	transcriptional regulator	NA	NA	NA	NA
WP_159595283.1\|4575898_4576327_-	DNA-binding protein	NA	NA	NA	NA
WP_159595284.1\|4576595_4577318_-	hypothetical protein	NA	NA	NA	NA
WP_159591368.1\|4577502_4578724_+\|transposase	IS3 family transposase	A0A0N7C1X7	Escherichia_phage	1.8e-49	38.8
WP_159595285.1\|4578999_4579575_-	hypothetical protein	NA	NA	NA	NA
WP_159595286.1\|4581492_4585098_-	hypothetical protein	NA	NA	NA	NA
WP_159595287.1\|4585411_4586335_+	DUF4238 domain-containing protein	NA	NA	NA	NA
WP_159595288.1\|4586359_4586548_-	hypothetical protein	NA	NA	NA	NA
WP_159595289.1\|4586549_4586981_-	hypothetical protein	NA	NA	NA	NA
WP_159595290.1\|4587094_4587640_+	hypothetical protein	NA	NA	NA	NA
WP_159595291.1\|4587823_4588267_+	hypothetical protein	NA	NA	NA	NA
WP_159595292.1\|4588358_4589195_-	Dam family site-specific DNA-(adenine-N6)-methyltransferase	A0A222YYM0	Escherichia_phage	5.5e-42	39.5
WP_159595293.1\|4589615_4592417_+	UvrD-helicase domain-containing protein	A0A1V0SAV1	Catovirus	7.5e-11	23.5
WP_159595294.1\|4592413_4593745_-	hypothetical protein	NA	NA	NA	NA
WP_159595295.1\|4593741_4600008_-	DUF4011 domain-containing protein	NA	NA	NA	NA
WP_159595296.1\|4600004_4600640_-	4Fe-4S cluster-binding domain-containing protein	NA	NA	NA	NA
WP_159595297.1\|4600636_4602445_-	AAA domain-containing protein	A0A2L0V0F4	Agrobacterium_phage	5.7e-36	32.9
WP_159595298.1\|4602474_4603587_-	DUF4236 domain-containing protein	NA	NA	NA	NA
WP_159595299.1\|4604495_4606106_+	hypothetical protein	NA	NA	NA	NA
WP_159595300.1\|4606047_4606728_+	hypothetical protein	NA	NA	NA	NA
WP_159595301.1\|4606731_4607595_+	hypothetical protein	NA	NA	NA	NA
WP_159595302.1\|4608265_4608838_-	hypothetical protein	NA	NA	NA	NA
WP_159590482.1\|4609234_4610322_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	7.1e-42	36.7
WP_159595303.1\|4611374_4611863_+	hypothetical protein	NA	NA	NA	NA
WP_159597035.1\|4612231_4613212_+\|transposase	IS5 family transposase	A0A077K814	Ralstonia_phage	4.2e-126	74.6
WP_159595304.1\|4613512_4617022_+	hypothetical protein	NA	NA	NA	NA
WP_159595305.1\|4617014_4617485_+	response regulator	NA	NA	NA	NA
WP_159595306.1\|4617481_4618729_+	hypothetical protein	NA	NA	NA	NA
WP_159595307.1\|4618775_4619237_+	hypothetical protein	NA	NA	NA	NA
WP_159595308.1\|4620520_4621297_+	HNH endonuclease	NA	NA	NA	NA
WP_159595309.1\|4621283_4621505_+	hypothetical protein	NA	NA	NA	NA
WP_159595310.1\|4621497_4623120_+	DUF2326 domain-containing protein	NA	NA	NA	NA
WP_159590431.1\|4623348_4624580_-\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	4.0e-134	83.6

DBSCAN-SWA_5

5813085 : 5821231

Acinetobacter_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_159589020.1\|5813085_5814276_-	elongation factor Tu	M4M9V7	Vibrio_phage	2.0e-05	70.6
WP_159596312.1\|5814782_5815514_-	uracil-DNA glycosylase	A0A286RUF9	Beluga_whale_alphaherpesvirus	4.5e-48	57.9
WP_159596313.1\|5815521_5816322_-	indole-3-glycerol phosphate synthase TrpC	A0A0P0IR83	Acinetobacter_phage	7.2e-60	51.3
WP_159596314.1\|5816336_5817389_-	anthranilate phosphoribosyltransferase	A0A0N7IRD9	Acinetobacter_phage	7.0e-79	46.7
WP_159596315.1\|5817404_5818043_-	LysE family transporter	NA	NA	NA	NA
WP_159596316.1\|5818056_5819130_-	low-specificity L-threonine aldolase	NA	NA	NA	NA
WP_159596317.1\|5819126_5819735_-	anthranilate/aminodeoxychorismate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	3.6e-67	63.4
WP_159596318.1\|5819731_5821231_-	anthranilate synthase component I	S4VT78	Pandoravirus	3.5e-39	29.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP044551

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP044550

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. NZ_CP044549

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection