CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP028260	Pediococcus pentosaceus strain SRCM102736 plasmid unnamed1, complete sequence	0 crisprs	NA	0	0	5	0
NZ_CP028259	Pediococcus pentosaceus strain SRCM102736 chromosome, complete genome	2 crisprs	DinG,cas3,csa3,DEDDh,WYL	0	0	7	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 1423

Enterococcus_phage(100.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_160208620.1\|472_1423_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A096XT60	Enterococcus_phage	9.4e-99	54.6

DBSCAN-SWA_2

6018 : 8256

Staphylococcus_prophage(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_121054781.1\|6018_6939_+\|transposase	IS30 family transposase	Q9MBM9	Staphylococcus_prophage	1.6e-50	37.2
WP_160208625.1\|7029_8256_+	PDZ domain-containing protein	A0A1B1IT49	uncultured_Mediterranean_phage	1.9e-19	29.7

DBSCAN-SWA_3

14563 : 18430

Lactobacillus_phage(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014081540.1\|14563_14815_+\|transposase	IS3 family transposase	Q6J1X3	Lactobacillus_phage	6.0e-37	95.2
WP_160208633.1\|14868_15678_+\|transposase	IS3 family transposase	Q6J1X2	Lactobacillus_phage	1.3e-146	97.0
WP_081035682.1\|16137_16740_+	recombinase family protein	A0A0F7LA37	Escherichia_phage	4.0e-18	39.1
WP_010625593.1\|17223_17544_-	hypothetical protein	NA	NA	NA	NA
WP_055126653.1\|17530_18430_-	AAA family ATPase	F0PIG8	Enterococcus_phage	1.5e-29	33.2

DBSCAN-SWA_4

25019 : 38517

Streptococcus_phage(40.0%)

holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_160208638.1\|25019_27155_+	DNA topoisomerase III	A0A1X9I6W8	Streptococcus_phage	3.3e-107	45.4
WP_003713050.1\|27275_27491_+	hypothetical protein	NA	NA	NA	NA
WP_160208639.1\|27493_28618_+	hypothetical protein	NA	NA	NA	NA
WP_021353390.1\|28772_28862_-\|holin	putative holin-like toxin	NA	NA	NA	NA
WP_160208641.1\|29048_30350_-	restriction endonuclease subunit S	A0A2H4PQP5	Staphylococcus_phage	1.1e-20	25.0
WP_160208643.1\|30339_31962_-	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	2.8e-127	50.1
WP_160208644.1\|31975_35143_-	type I restriction endonuclease subunit R	A0A220A398	Liberibacter_phage	4.8e-22	22.8
WP_160208646.1\|36523_36910_-	hypothetical protein	NA	NA	NA	NA
WP_160208648.1\|36902_37223_-	acetyl-CoA carboxylase	NA	NA	NA	NA
WP_160208650.1\|37215_38517_-	Y-family DNA polymerase	M1Q231	Streptococcus_phage	3.0e-79	39.1

DBSCAN-SWA_5

49747 : 51916

Enterococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_160208660.1\|49747_51916_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A8E2R1	Enterococcus_phage	2.1e-255	60.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP028259

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP028259_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP028259_1

867035-867147

Orphan

Consensus_repeat	Method
TGACTTCCTGAATCTAACTGTTGAACGCC	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP028259_1

>merge|NZ_CP028259|1|867035-867147|CRISPRCasFinder
TGACTTCCTGAATCTAACTGTTGAACGCCGCTAATCAAGGTTCCTGTGCTTCCATTTAGAGTTTGAAGTCCGCTATTCAATGTGTGACTTCCTGAATCTAATTGTTGAACGCC

>NZ_CP028259|1|1|867035-867147|CRISPRCasFinder
TGACTTCCTGAATCTAACTGTTGAACGCC	GCTAATCAAGGTTCCTGTGCTTCCATTTAGAGTTTGAAGTCCGCTATTCAATGTG
TGACTTCCTGAATCTAATTGTTGAACGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP028259.1\|WP_002834264.1\|874809_875922_-\|low-temperature-requirement-protein-A	unknown	unknown	gnl\|CDD\|377704
NZ_CP028259.1\|WP_011673877.1\|869601_869922_-\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP028259.1\|WP_060743513.1\|876964_877690_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|376350
NZ_CP028259.1\|WP_141822893.1\|858406_859525_-\|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	unknown	unknown	gnl\|CDD\|213783
NZ_CP028259.1\|WP_160208480.1\|870013_870559_-\|DUF1836-domain-containing-protein	unknown	unknown	gnl\|CDD\|378076
NZ_CP028259.1\|WP_002834184.1\|857423_858404_-\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
NZ_CP028259.1\|WP_060743520.1\|865363_865999_-\|DUF4767-domain-containing-protein	unknown	unknown	gnl\|CDD\|374270
NZ_CP028259.1\|WP_060743524.1\|860803_862147_-\|PTS-sugar-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|224372
NZ_CP028259.1\|WP_011673888.1\|881033_882284_-\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NZ_CP028259.1\|WP_036673200.1\|859536_860523_-\|lipoate--protein-ligase	unknown	unknown	gnl\|CDD\|161920
NZ_CP028259.1\|WP_141822899.1\|871602_872442_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|236841
NZ_CP028259.1\|WP_141822897.1\|863703_864417_+\|UTRA-domain-containing-protein	unknown	unknown	gnl\|CDD\|225099
NZ_CP028259.1\|WP_141822895.1\|862161_863544_-\|family-1-glycosylhydrolase	unknown	unknown	gnl\|CDD\|225343
NZ_CP028259.1\|WP_060743527.1\|854708_856115_-\|dihydrolipoyl-dehydrogenase	unknown	unknown	gnl\|CDD\|235798
NZ_CP028259.1\|WP_023440867.1\|877686_878889_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NZ_CP028259.1\|WP_060743521.1\|864450_865104_-\|nitroreductase	unknown	unknown	gnl\|CDD\|380313
NZ_CP028259.1\|WP_060743514.1\|876075_876912_+\|manganese-catalase	unknown	unknown	gnl\|CDD\|252986
NZ_CP028259.1\|WP_060743518.1\|870536_871400_-\|DegV-family-protein	unknown	unknown	gnl\|CDD\|273257
NZ_CP028259.1\|WP_094104217.1\|872861_874667_-\|DUF2207-domain-containing-protein	unknown	unknown	gnl\|CDD\|378333
NZ_CP028259.1\|WP_060743526.1\|856117_857431_-\|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl\|CDD\|237001

Protein	Function_ID	Function_description	E-value
NZ_CP028259.1\|WP_002834264.1\|874809_875922_-\|low-temperature-requirement-protein-A	gnl\|CDD\|377704	pfam06772, LtrA, Bacterial low temperature requirement A protein (LtrA). This family consists of several bacteria specific low temperature requirement A (LtrA) protein sequences which have been found to be essential for growth at low temperatures in Listeria monocytogenes.	1.87144e-45
NZ_CP028259.1\|WP_011673877.1\|869601_869922_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	8.63436e-15
NZ_CP028259.1\|WP_060743513.1\|876964_877690_-\|EAL-domain-containing-protein	gnl\|CDD\|376350	pfam00563, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.	3.88171e-22
NZ_CP028259.1\|WP_141822893.1\|858406_859525_-\|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	gnl\|CDD\|213783	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	8.19984e-159
NZ_CP028259.1\|WP_160208480.1\|870013_870559_-\|DUF1836-domain-containing-protein	gnl\|CDD\|378076	pfam08876, DUF1836, Domain of unknown function (DUF1836). This family of proteins are functionally uncharacterized.	2.34467e-37
NZ_CP028259.1\|WP_002834184.1\|857423_858404_-\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	2.88289e-177
NZ_CP028259.1\|WP_060743520.1\|865363_865999_-\|DUF4767-domain-containing-protein	gnl\|CDD\|374270	pfam15983, DUF4767, Domain of unknown function (DUF4767). This domain family is found in bacteria, and is approximately 140 amino acids in length. There is a single completely conserved residue Q that may be functionally important.	3.84102e-47
NZ_CP028259.1\|WP_060743524.1\|860803_862147_-\|PTS-sugar-transporter-subunit-IIC	gnl\|CDD\|224372	COG1455, CelB, Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism].	3.60599e-117
NZ_CP028259.1\|WP_011673888.1\|881033_882284_-\|PDZ-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	3.64249e-82
NZ_CP028259.1\|WP_036673200.1\|859536_860523_-\|lipoate--protein-ligase	gnl\|CDD\|161920	TIGR00545, Probable_lipoate-protein_ligase_A, lipoyltransferase and lipoate-protein ligase. One member of this group of proteins is bovine lipoyltransferase, which transfers the lipoyl group from lipoyl-AMP to the specific Lys of lipoate-dependent enzymes. However, it does not first activate lipoic acid with ATP to create lipoyl-AMP and pyrophosphate. Another member of this group, lipoate-protein ligase A from E. coli, catalyzes both the activation and the transfer of lipoate. Homology between the two is full-length, except for the bovine mitochondrial targeting signal, but is strongest toward the N-terminus. [Protein fate, Protein modification and repair].	7.17989e-88
NZ_CP028259.1\|WP_141822899.1\|871602_872442_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|236841	PRK11088, rrmA, 23S rRNA methyltransferase A; Provisional.	8.78866e-39
NZ_CP028259.1\|WP_141822897.1\|863703_864417_+\|UTRA-domain-containing-protein	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	5.94431e-56
NZ_CP028259.1\|WP_141822895.1\|862161_863544_-\|family-1-glycosylhydrolase	gnl\|CDD\|225343	COG2723, BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism].	4.52665e-172
NZ_CP028259.1\|WP_060743527.1\|854708_856115_-\|dihydrolipoyl-dehydrogenase	gnl\|CDD\|235798	PRK06416, PRK06416, dihydrolipoamide dehydrogenase; Reviewed.	0
NZ_CP028259.1\|WP_023440867.1\|877686_878889_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	9.43646e-50
NZ_CP028259.1\|WP_060743521.1\|864450_865104_-\|nitroreductase	gnl\|CDD\|380313	cd02136, PnbA_NfnB-like, nitroreductase similar to Mycobacterium smegmatis NfnB. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.	3.0082e-40
NZ_CP028259.1\|WP_060743514.1\|876075_876912_+\|manganese-catalase	gnl\|CDD\|252986	pfam05067, Mn_catalase, Manganese containing catalase. Catalases are important antioxidant metalloenzymes that catalyze disproportionation of hydrogen peroxide, forming dioxygen and water. Two families of catalases are known, one having a heme cofactor, and this family that is a structurally distinct family containing non-heme manganese.	4.26212e-119
NZ_CP028259.1\|WP_060743518.1\|870536_871400_-\|DegV-family-protein	gnl\|CDD\|273257	TIGR00762, DegV, EDD domain protein, DegV family. This family of proteins is related to DegV of Bacillus subtilis and includes paralogous sets in several species (B. subtilis, Deinococcus radiodurans, Mycoplasma pneumoniae) that are closer in percent identity to each than to most homologs from other species. This suggests both recent paralogy and diversity of function. DegV itself is encoded immediately downstream of DegU, a transcriptional regulator of degradation, but is itself uncharacterized. Crystallography suggested a lipid-binding site, while comparison of the crystal structure to dihydroxyacetone kinase and to a mannose transporter EIIA domain suggests a conserved domain, EDD, with phosphotransferase activity. [Unknown function, General].	1.84768e-94
NZ_CP028259.1\|WP_094104217.1\|872861_874667_-\|DUF2207-domain-containing-protein	gnl\|CDD\|378333	pfam09972, DUF2207, Predicted membrane protein (DUF2207). This domain, found in various hypothetical bacterial proteins, has no known function.	1.17059e-114
NZ_CP028259.1\|WP_060743526.1\|856117_857431_-\|2-oxo-acid-dehydrogenase-subunit-E2	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	1.05589e-159

>NZ_CP028259.1|WP_060743520.1|865363_865999_-|DUF4767-domain-containing-protein
MRHMKKPEKRSFGSINSVVWVILALIVVIAGYKFFYPNHVTNTTSSSDRSSSTKVIKVEEGKSSSSKAQSSSKKTKKTEKKIWTDKQDSELAAFISSWQQTMGQTYTGTNTNASVSFGGVSFPDYLSKGQIYVNQQEVSMQWTRSEKSDSEYKVVAVYTGDQYMYLFTFHNGQPEVLVTSQSASNGMNFKVTENADLVAEFQKVAAENTDK
>NZ_CP028259.1|WP_060743521.1|864450_865104_-|nitroreductase
MEVKQAIQKRHSVRHFTDQKIDSKQLKEMIGIAQKAPSWVNSQPQKVYVAQGETLEAIRKQQQELTITGAKTNSDIPPMSRKLWSEQAQKNMAEWSHGIPAVLGDNWQETLGKEASQLYNAQAVVYLTLPKGYTPWSLFDLGAFSQNILLATTEQGIDSIVAYNFVKYPQILREELKIPDDEEIIVGIGLGFEDEQAQVNRITSKRMDTESILKIKK
>NZ_CP028259.1|WP_141822897.1|863703_864417_+|UTRA-domain-containing-protein
MYKYEKISQAIRKQIIEQKIKPGALLPDQNQLAKEFNTTRITIGKALQSLIIEGLIYSKRGAGTFVRKDAHLNDEFTNDVDKPLGTTSTHPHSKVTSKYIHLTARIANEVEKKNLLLEDGETVYVIKRTRFIEGKAYSYEQTIMPTKIATITEEVLKKSIYQYLENEYHLELAGSHRQITARKVSEEDAKFLGEKLGDPILVISQTSYLVDGTPFEFSESRFPYQSSAVSADVNLLE
>NZ_CP028259.1|WP_141822895.1|862161_863544_-|family-1-glycosylhydrolase
MKGKLPDNFLWGNSTSSMQTEGGVHEGGKGPSVYDTYEATETTSNWDVAIDNYHHYEEDLDLMANQGMNCYRFQISWSRVNPTGDGDFNEEGIQYYDRLINDLLKRGIKPMICLYHFDMPLHLAEKYNGFMSRHVVDAFVRFGKKMVDCFSDRVKLWVTFNEQNLYSQTEAFHIAGYLKGDQTDEELQLIAHHVMTAHAQVTNYVHETSDAQIGGMLAYVESYPKNCRPHDVYVARQIDEFLNRNLLEVWVHGHYSTEVTQYIKNHHFDIDFTEQDQIAFEKLKSDFISFSYYASNVVDSTKIPQGTMPNRYLDYGGVENPYLKATDWGWNIDPLGFRDVITKTYNEYGIPMFPIENGIGYREAFDGTEIQDDYRIEYHRDHIQAMIDAVVEDGVPVLGYLGWGLIDIPSSSGNMEKRYGMVYVNRGNHELRDMKRVPKKSYKWFKKVIETNGNDLENDL
>NZ_CP028259.1|WP_060743524.1|860803_862147_-|PTS-sugar-transporter-subunit-IIC
MGSSNKESVNDKMQNSKFIAKFTEISVKVGNWVYLRSLRDAFAVILPMFIVAGIGVLLNNVVFTWFLSGDMLTKFQVIGNAIVNGTLNVAGILVAPMIGYSLARNKGFNNPIAAAAMSLASIFILMPGSIQLGTVASAGAKMATVTGGLSYLNTGTQGMFGGIFVGLIATGLFIKLASIKKLQIHLGENVPPAVAASFSVLIPAILLMSFFAIIAALLAGFFNTDLINLIKTWIQEPLRGFNTSIVGYCVIYTLANFLFGLGIHQTVLSGALLDPLVLVNMNENMTAYAHHQAIPNIITTSFVSNYTLIGGSGSTIALIIAILIFSKAKSSRQIAGLSLAPGIFNINEPMIFGFPIVFNLPLIIPFVLFPVVGSLMGYFATLWGWVSRTVVLVPWTTPPLIGPYLSTAGDWRAVILQILIIVVGVFLYLPFLKISERVSEIQAEENL
>NZ_CP028259.1|WP_036673200.1|859536_860523_-|lipoate--protein-ligase
MRYVTYMGTDAYTNIATDTWLLNNLNAKEPVFALWQNNNAIIVGQNQNTFGEVNQDFVDEHQIEVVRRVTGGGAVYHDLGNLNFTLFVPIESAANVDFKKFSEPVLRALHTLGIDAEASGRNDLLVNGKKISGVAQRYAKGYLMHHGTLLFDSNVDTMVRSLNVADEKFISKAAKSVRSRVGMIKDAAPKGLTLQDFWDAVQYELTDHGKDQEIVLTPQQKQEIIQLTADKFSTWDWNYGRSPEFNFKNHAKYDGGIIDVQVQAEGGTIRDINFTGDFLGLRDWREIKDQFIGLPFETAEIKTVFERNHEGRYFGNITDDELIKLFEA
>NZ_CP028259.1|WP_141822893.1|858406_859525_-|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha
MAVKDDNKQVLDFNLQIEKQTDSFPMLQVLNNDGEIVDEDALKEAGLNEDQLVELMKQMVFSRVLHERSTKLAKQGRLGFYAPTIGEEASQIASNYAFEKGDWLFPGYRDIPQLVMKGWPIYKAFLWSRGHYEGNEFDDVNGWMPQIIIGAQYVEAAGAALGLKMRKQPNVAYAYTGDGGTSQGDFYEGMNFAGAYNAPAVFFSQNNEYAISTPRKLQTKAPHLAAKGWAAGLPSLVVDGMDPIAMYLASKKARQWAVDGNGPVFIETITNRLGAHSMSGDDPLRYRTQEEIDEWTKKEPLIRFRKYLEGLGLWSEEIENDWTEVVNEQIDDGVKQADGIDKQKISDFIEQTLEVPGQAAQEQINKFRGEGK
>NZ_CP028259.1|WP_002834184.1|857423_858404_-|alpha-ketoacid-dehydrogenase-subunit-beta
MAQKTYIQAITEAQDLALANDENVVIFGEDVGKNGGVFRATDGLQAKYGEDRVFNTPLAESGIGGMAIGMTTQNYRPIMEIQFFGFVYEVMDSLAGQMARGRFRFHGTRTFPIVVRSPYGGGTKTPEMHADSLEGLVAQTPGLRVVMPATPADAKGLLLSAVESNDPVIFLENLRLYRSIRGDVPEGYYTTPLDKANVIREGKDVSIITYGGMVHTSLAAAEELAKDGIDAEVVDLRTVSPLDLDTIGESVEKTGRVVVAQEAQRQAGIGAMVMSEISERFIMSLKAPIGRVAAPDSVYPFALAENEWLPKADDIIEKVKEVVNFD
>NZ_CP028259.1|WP_060743526.1|856117_857431_-|2-oxo-acid-dehydrogenase-subunit-E2
MTEIFKMPDIGEGMAEGEIANWLVKVGDTIKEEDAVAEVQNDKLLQEILSPYGGKITKLFVEAGTVVKVGEPLIEFDGDGSGAGAESEAPKETPASTEPEPESSAPVNQTAPEVTKVGAEYTSNGQLLAMPSVREYARKNDIDLTQVPATGRHGHITMADVENFKASPASAPTASPAPAASVPETESEKAPSAPATPAAPAEVKAGRVPLSPVRKVIAKTLTNQVQTIPHVTIMDEVEVSKLMDLRNQFKEQAKQKGYKLTYMPFIAKALAGAAHKYPELSAMVDIEKQEIVYYEDTNVSFAVDTDNGLFVPNVKNVKSKSIMEVAQEIDDMAIRGRAGDLKPNELKGGTVTITNIGSESGSGFFTPIINPGESAILGIGRIRKTPVVNEDGELAVGNTLKLSLSFDHRLIDGALAQKIMNELKALLSNPAYMLMEV
>NZ_CP028259.1|WP_060743527.1|854708_856115_-|dihydrolipoyl-dehydrogenase
MVVGTQAINVDTLIIGSGPGGYVAAIRAAELGQKVVIVERDYIGGVCLNVGCIPSKALIQAGHLYSTLQHGNPFGVSVSESKIDFTKTQEWKQNQVVNKLTGGVELLLKKHKVEIVRGEAYFNDNETVNVINGDDSHVYRFKRALIATGSRPVEIPHFKFSGRVIDSTGALNLKDVPEHLIIIGGGVIGAELAGAYMNLGSKITIIEGLDHILNGFDGELIQPVLNNFKKNGVEIVTEATAVEANQTDKDVTVTYEADGTTKTVTGDYCLVSVGRRPNTDQLGLNNTNIKLSKRGLIEVNDSMQTSVKHIYAIGDVVAGPALAHKASFEAKVAAAAMGGEDAHDTHYVLPAVAYTNIELATVGETPQSIAEKKLDAKSSKFPFAASGRAMTMDQTEGFIRLITDNPTGGIIGAQIVGPEASNLISELTLAIENGLTIKDIELTIHPHPTLGEEIMDAAELAAGLPIHV
>NZ_CP028259.1|WP_011673877.1|869601_869922_-|winged-helix-turn-helix-transcriptional-regulator
MVKNNAALAAFKKNIPLLDALSDERRQQIMITLGESDAGLTVSELTKLIGLSQPAVSHHIKQLKDLNLVSVRKVGTSNIYQLTIKDALAQVQELIDILRKDKKLLR
>NZ_CP028259.1|WP_160208480.1|870013_870559_-|DUF1836-domain-containing-protein
MVYKLLNKVIEGDQMDSKQLENFAKMSLPKWDELPNIELHLDQVIDLANNYLRPLEVDLLTPTMMHNYLKQAVIIRPQGKLYGRMQLAAVIIIGCLKSIFSLDEIKRGFEAELKLTSSRRAYNNFVNAFNEEVQRISQHGPRNLWNELLAETAVVSLQHSAIISMLTKKMAKDLLSDLEEK
>NZ_CP028259.1|WP_060743518.1|870536_871400_-|DegV-family-protein
MLKQKIAVLVDSCSDVPAEIANREYFEMIPMGVFFGEEEYQDRVNIEPDEFYQKLAKANPLPTTASPKGELITKALDNLSKRGFTKIIAVCISSGLSGTAQQVKIYAKNYPQLQIEVIDTKNIGIASGFAAVRASEVIEEGWEFDQIVEEVQRVANQTKVFFYVPTLKYLIAGGRIGRVAGLVGSIINLKPIISCDDEGIYYPVAKAHGEKKALKKMLQLVDDTLKNAQKFNLAVVHGLNEGLMNQISTEFKNKYPNMGKIYNGDISPALGVHTGPGLIGIGVQIIK
>NZ_CP028259.1|WP_141822899.1|871602_872442_+|methyltransferase-domain-containing-protein
MNKIELATQFIQRHLHQFQCPICKSNFNEVQSGTLICNNQHSFNIAKKGSLFFLNNPVNTEYTNEMLTYRNQFLTAGFFNPMLEEVINNISGDLILDAGCGEGTTTKWMASHFDGDFVGLDISKPAINIAGSGIAPQPYPLFMVGDLAQLPFTDQGLTSIVNILSPANYQEFDRTLATHGELIKVIPGNHYLSELRQLVYPDGEHATYDNAPVKNHFIEHYEYVEFSKISYKFPLDDKLFTALFNMTPLTWQAQGRKEAILQDGLKEITAEFEIGVVRK
>NZ_CP028259.1|WP_094104217.1|872861_874667_-|DUF2207-domain-containing-protein
MKFFTKRTFLLLVTMLTFGIFWNVKTVKADYEISQFRMQINVNKDGSANINQSVLYDFDDDYHGVYLTQDLRGTAGAELEGITVSNNKGTQNQVPINNSGENLTAKVESSKKQMKIKVYNAVSSDDQTKITYHYRINGVVTNYKDTAEINWKVIGSGWDVPLEDAQVTIKLPGKNVKGLHAWSHGEAAGYTTVDKAKGKVTLDIGDNPENTFVEAHMVFPTALTPDNKKIVNQNHLAAVKKQEYQLVKRENEAQARARRIAAYAKITSAIISVLILIGMMGWLKKHGYHRYDIPTPMEHSFDVPSISPAEAEALFNKSKADTKGVSAEMLVLAAEGKLKFKQILYGKRGKETTEIERQGKFNMSFVDRCLDRIGDGQQVTIKQINDYAKKDKKNNVATWYKEWQSEVDANLARFKDTYNISYRHGLLGLAITTPILAFIVGIIGRFGEVTNLYWIGGIVLTLIIEAWVLATWDKVSMYNEAGLQQYNQIRGFKQMMKDIAHFNTAEIGDLILWEQILPYATAFGLAEKVAKKLKTDFGTQLNENVPFYAYYYGINGMHVGIANSISTSISHSVSASSSGSSGGFSGGSSGGFGGGSGGGAF
>NZ_CP028259.1|WP_002834264.1|874809_875922_-|low-temperature-requirement-protein-A
MKNELLKKVSMIELFYDLVFVYMISQVTGLIHHLQNGVISPSALSIFTLVVIVSINSWMVQTVFNNRYGKSQWSNVILSFVDMAIVLYMSNAFSDTFDRHLIGFFIAAGLLSLTLAIQYLLVFVQTKNEYDRNIAMAFMRILFFRTACLLAGGVLAGRWGTTIALFGIITSWIIPAFTGKHTQKHPIIFSHLLERLTALIIIMFGETIVGISKYFTQNTFSIQSIMIFIIVVSLFFTYIVEFDHLIEEQRTHETGNLLIYLHYFILFGLSLVTVALDFIHESEANAIFSITCLYVGIALFYIGIVIASYYNKTTLKLENYVVVAFIVVTLMGYFTSMCFATFSIIAGVTALTTLINAVVITLSLVRRYER
>NZ_CP028259.1|WP_060743514.1|876075_876912_+|manganese-catalase
MFKHQKELQFEAKPDRPDPIVAKYLQELIGGQYGEMSVAMQYLFQGWSCRGEEKYKDMIMDIATEEIGHVEMLATMVARLLEDAPIADQQAAMQANPTVGAIISGMNPQHAIIAGLGPRPADSVGNPWSGAYIIASGNLLADFRANLNAESQGRLQVARIYEMIDDQGVKDLLSVLLARDSYHQNLWASAVKELEEKEDSMLVPTTFPRDKERKDIAYDFYNFSQGDESSTGPWASGEALDGEGEYHWYDEPKVEGSAPNLKPVSPKMYGTPENKSEI
>NZ_CP028259.1|WP_060743513.1|876964_877690_-|EAL-domain-containing-protein
MSELEQKLEGICFYEQPIFLIDAAEKEEKKVIGSELLLRKTGGENRFPAMLYKEYMRDDASNLVFCTWLVKNIIEIINDNPGIQYSFNLDPQQLLYDSTFEAMKGLIPYCDRVMIEVTESIPNNRDIDQYFNYSVRDQIKRIHEMGFSVAVDDVSSGMNSFNAVREYTQDIDRLKLSLIQLRNVEEGMITVTISLWKALAANTGIDLVIEGIDSLEVSKWLLENGLEKQQGYYFATPRKLK
>NZ_CP028259.1|WP_023440867.1|877686_878889_-|GGDEF-domain-containing-protein
MENTVMNTIIYWAKGFFSFNTVVIAAITVGVLFMLAAGTYVVEMNMDKTKTSSTLIEELLWGVGLTIAMVFLQNVFTHLYSTIASSELGWEYSTAQFVVLFYCLYIVHRKVVLWFNIILPMYVYGLGIVRGQIGFDIAPILAILVIILISYTIYQQNDTLIDENVKYYSTLIMFGLAWWFVLKDIHHLTIVDIMCLTLEFLIAMSIVHFGNKKVRMIMKQYLNLMQEVDTDALTGVYNRNSFNKVVEGVFEFYSNNDAPLTMVMFDIDHFKQFNDQYGHQVGDKVLRLVADRFSYELVDRKAHGQLFRVGGEEFAIIFRGRTADDCEKIVRAIRDDLVKETIRVNNHDRVGIKVSIGISQLRDDDFDFQTFYKRVDDYLYQSKRNKRNSITVEGKVASLN
>NZ_CP028259.1|WP_011673888.1|881033_882284_-|PDZ-domain-containing-protein
MKTNKLVIVAAIAGLLGGGVAYGGASFIHNQMESSSTAVPTGSNTTGTTKTSNVKVNVSSQSSKAFSTIKDSVVSVINLQKANTNDSDSIISSIFGNESSSSSKSSSSSSELETASEGSGVIYKKSGDTAYIVTNNHVVSGSSSLEIIMSNGKKLPAKIVGTDSVTDLAVLKINSSAVTTVASFGNSDNIKVGETALAIGSPLGSEYATSLTQGIISAKKRTVETTTENGQNNGEATVIQTDAAINAGNSGGPLINLAGQVIGINSMKLSASGSDSTTVEGMGFAIPSNEVVTIIDQLVKNGKITRPALGVALVDLTQVSSTQQKSILKLPSNVTDGTVLMQVNNGPAKTAGLKKYDVITKIDDKAITDTAGLREALYKHKINDKITVGYYRDGKYKTTVVTLTKTSTTTSSTTTK

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Crispr_ID: NZ_CP028259_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP028259_2

1592091-1592196

Orphan

Consensus_repeat	Method
TTAGCTCAGTTGGGAGAGCATCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP028259_2

>merge|NZ_CP028259|2|1592091-1592196|CRISPRCasFinder
TTAGCTCAGTTGGGAGAGCATCTGCCTTACAAGCAGGAGGTCACAGGTTCGAGCCCTGTATCCCCCATTATATTTTGAGCCGTTAGCTCAGTTGGTAGAGCATCTG

>NZ_CP028259|2|2|1592091-1592196|CRISPRCasFinder
TTAGCTCAGTTGGGAGAGCATCTG	CCTTACAAGCAGGAGGTCACAGGTTCGAGCCCTGTATCCCCCATTATATTTTGAGCCG
TTAGCTCAGTTGGTAGAGCATCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP028259.1\|WP_060743450.1\|1584436_1585453_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NZ_CP028259.1\|WP_002833902.1\|1580285_1580552_+\|phosphocarrier-protein-HPr	unknown	unknown	gnl\|CDD\|237503
NZ_CP028259.1\|WP_002833742.1\|1596855_1598046_+\|methionine-adenosyltransferase	unknown	unknown	gnl\|CDD\|235374
NZ_CP028259.1\|WP_060743928.1\|1605482_1606202_+\|16S-rRNA-pseudouridine(516)-synthase	unknown	unknown	gnl\|CDD\|211327
NZ_CP028259.1\|WP_141822526.1\|1594148_1595882_+\|pyruvate-oxidase	unknown	unknown	gnl\|CDD\|213733
NZ_CP028259.1\|WP_060743449.1\|1583211_1584387_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340844
NZ_CP028259.1\|WP_160208561.1\|1601167_1603585_+\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234743
NZ_CP028259.1\|WP_060743927.1\|1603788_1605474_+\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|240529
NZ_CP028259.1\|WP_060743451.1\|1585466_1586501_+\|flippase-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|377103
NZ_CP028259.1\|WP_141822530.1\|1606224_1607064_-\|NAD(P)H-hydrate-dehydratase	unknown	unknown	gnl\|CDD\|238576
NZ_CP028259.1\|WP_060743924.1\|1598120_1599587_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP028259.1\|WP_002833903.1\|1579951_1580140_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028259.1\|WP_029257840.1\|1577527_1579747_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|223616
NZ_CP028259.1\|WP_141822528.1\|1595951_1596683_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028259.1\|WP_002833901.1\|1580551_1582276_+\|phosphoenolpyruvate--protein-phosphotransferase	unknown	unknown	gnl\|CDD\|224006
NZ_CP028259.1\|WP_011673186.1\|1600189_1600822_-\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239486
NZ_CP028259.1\|WP_002833906.1\|1576265_1577111_+\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NZ_CP028259.1\|WP_002833905.1\|1577110_1577473_+\|DUF1634-domain-containing-protein	unknown	unknown	gnl\|CDD\|377927
NZ_CP028259.1\|WP_060743448.1\|1582348_1583122_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP028259.1\|WP_060743925.1\|1599624_1600197_-\|16S-rRNA-(cytosine(1402)-N(4))-methyltransferase	unknown	unknown	gnl\|CDD\|377744

Protein	Function_ID	Function_description	E-value
NZ_CP028259.1\|WP_060743450.1\|1584436_1585453_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	6.96569e-34
NZ_CP028259.1\|WP_002833902.1\|1580285_1580552_+\|phosphocarrier-protein-HPr	gnl\|CDD\|237503	PRK13780, PRK13780, phosphocarrier protein HPr; Provisional.	1.69391e-54
NZ_CP028259.1\|WP_002833742.1\|1596855_1598046_+\|methionine-adenosyltransferase	gnl\|CDD\|235374	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated.	0
NZ_CP028259.1\|WP_060743928.1\|1605482_1606202_+\|16S-rRNA-pseudouridine(516)-synthase	gnl\|CDD\|211327	cd02553, PseudoU_synth_RsuA, Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RsuA makes psi516 in 16S RNA. Psi at this position is not generally conserved in other organisms.	3.89863e-88
NZ_CP028259.1\|WP_141822526.1\|1594148_1595882_+\|pyruvate-oxidase	gnl\|CDD\|213733	TIGR02720, Pyruvate_oxidase, pyruvate oxidase. Members of this family are examples of pyruvate oxidase (EC 1.2.3.3), an enzyme with FAD and TPP as cofactors that catalyzes the reaction pyruvate + phosphate + O2 + H2O = acetyl phosphate + CO2 + H2O2. It should not be confused with pyruvate dehydrogenase [cytochrome] (EC 1.2.2.2) as in E. coli PoxB, although the E. coli enzyme is closely homologous and has pyruvate oxidase as an alternate name. [Energy metabolism, Aerobic].	0
NZ_CP028259.1\|WP_060743449.1\|1583211_1584387_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340844	cd03817, GT4_UGDG-like, UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.	1.17295e-136
NZ_CP028259.1\|WP_160208561.1\|1601167_1603585_+\|leucine--tRNA-ligase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0
NZ_CP028259.1\|WP_060743927.1\|1603788_1605474_+\|polysaccharide-biosynthesis-protein	gnl\|CDD\|240529	cd13124, MATE_SpoVB_like, Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins. The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	1.33255e-136
NZ_CP028259.1\|WP_060743451.1\|1585466_1586501_+\|flippase-like-domain-containing-protein	gnl\|CDD\|377103	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region. LPG_synthase_TM is the N-terminal region of this family of bacterial phosphatidylglycerol lysyltransferases. The function of the family is to add lysyl groups to membrane lipids, and this region is the transmembrane domain of 7xTMs. In order to counteract attack by membrane-damaging external cationic antimicrobial molecules - from host immune systems, bacteriocins, defencins, etc - bacteria modify their anionic membrane phosphatidylglycerol with positively-charged L-lysine; this results in repulsion of the foreign cationic peptides.	5.48802e-33
NZ_CP028259.1\|WP_141822530.1\|1606224_1607064_-\|NAD(P)H-hydrate-dehydratase	gnl\|CDD\|238576	cd01171, YXKO-related, B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.	8.41581e-77
NZ_CP028259.1\|WP_060743924.1\|1598120_1599587_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	5.89451e-64
NZ_CP028259.1\|WP_029257840.1\|1577527_1579747_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl\|CDD\|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP028259.1\|WP_002833901.1\|1580551_1582276_+\|phosphoenolpyruvate--protein-phosphotransferase	gnl\|CDD\|224006	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism].	0
NZ_CP028259.1\|WP_011673186.1\|1600189_1600822_-\|phosphatase-PAP2-family-protein	gnl\|CDD\|239486	cd03392, PAP2_like_2, PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	1.97509e-52
NZ_CP028259.1\|WP_002833906.1\|1576265_1577111_+\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	1.61547e-34
NZ_CP028259.1\|WP_002833905.1\|1577110_1577473_+\|DUF1634-domain-containing-protein	gnl\|CDD\|377927	pfam07843, DUF1634, Protein of unknown function (DUF1634). This family contains many hypothetical bacterial and archaeal proteins. A few members of this family are annotated as being putative transmembrane proteins, and the region in question in fact contains many hydrophobic residues.	1.23608e-28
NZ_CP028259.1\|WP_060743448.1\|1582348_1583122_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.68968e-24
NZ_CP028259.1\|WP_060743925.1\|1599624_1600197_-\|16S-rRNA-(cytosine(1402)-N(4))-methyltransferase	gnl\|CDD\|377744	pfam06962, rRNA_methylase, Putative rRNA methylase. This family contains a number of putative rRNA methylases. Note that many family members are hypothetical proteins.	2.9405e-74

>NZ_CP028259.1|WP_060743451.1|1585466_1586501_+|flippase-like-domain-containing-protein
MSRRNKVVLAVMILAGIVIFGFSLRNVNLNQMARDVVHLNMWWLLVALGCIVLYLGLEAVATKMLIQSNGDRLSWRDAIRIPLIEQLFNGITPFSSGGQPAQLVALMQNGIEGGRASSVLLMKFVVFQSMVVINFIFSLLIGFQYLEEKIRFLSWFVLFGFLIHLAVIIGLLMIMYWHNFTKRLISAIFIPIKHFVSKERYTTWKVTLNEKVDSFYQESVRMKSQWRLLAKVALVTFLQLLFYYLIPYFILLALGKSDVNIVMVTCLHVLIFMVISLFPIPGGAGGAEYGFSVIFAQFVGNNSKLVLAMMIWRILTYYFGMFAGMVATVVKPHKVNRVKVVKNE
>NZ_CP028259.1|WP_060743450.1|1584436_1585453_+|glycosyltransferase-family-4-protein
MPIKVNMFSSASKVKGQGVGSAYEELIRLLKTHFPKQIDVSINKFIKADISHYHTIDPNFYLSTFSKKRGIKVGYVHFLPETIEGSLNIPQPFRSIFYKYIISFYKRMDHIVVVNPTFIDKLVAYGISRDIITYIPNFVRKNEFYRFTEANRDAVRERLEVNNRFTVLGIGQVQERKGVKDFIKLAENNPDKYFIWAGGFSFGRLTDGYADLKQVVDNPPRNLKFTGIVDRNALVEYYNAADLFLLPSYNELFPMSVLEAFSCGVPVMLRDLELYHSIIKGYYIPTQDYEDMNTQLKLVSEDKERLNKFKQLSDEASEEYSEDHLADIWLDFYSSLTK
>NZ_CP028259.1|WP_060743449.1|1583211_1584387_+|glycosyltransferase-family-4-protein
MNIGLFTDTYFPQVSGVATSIKTLRDQLEKQGHQVYIFTTTDPKVDTNVYERNIFRFTSVPFVSFTDRRIAVSGFIRAAQLAKELNLDIVHTQTEFSLGWMGKFVAKSLKIPLIHTYHTMYEDYLHYVANGKLLKPYHVKQMMRAFCYHIDGIVAPSERVLDTIEGYGINVPIRVIPTGVNLEQYQKPNKRKQWREKLGYDESSPILLSLSRLAYEKNIQEVIDSFPAILKEVPNAQLLIVGDGPARASLENQVHDLHLEDSVQFTGEINNDHVYGFYQLADLFVSASDTESQGLTYIEALASNLKVVAKSGPYTDELLDDISLGKVFNTEDQLVAAIKDYIEHPDAYNDPAPREKKLYEISADYFGKQVVDYYSSAISTHTDLELDEDSE
>NZ_CP028259.1|WP_060743448.1|1582348_1583122_+|alpha/beta-hydrolase
MKLKLKSGAQIFFEDEGQGTPILFLTGFGGNTEIWSGQVNFFLQRGYRVIRLDYLNHGQSDRVDGELQIGDLADEVLQLVDYLQLKEPIGIGNSMGAAVLWNIINLRGWDFLSKAIFVDQSPKMLNDQQWHLGFKNLAEDNFDEVMNEPIVRPAYKHIDDFVFKNSKAIDSAYPFSQPQNRALVKGHAKKDWRFVLEQATKPVLFIMGEKSPFFDSTKTAELSALNANITVNVMKNVGHIPMAEDPTEFNRLVLQFV
>NZ_CP028259.1|WP_002833901.1|1580551_1582276_+|phosphoenolpyruvate--protein-phosphotransferase
MAGTLKGIAASDGIAIAKAYLMVDPDLSFEKKNITDVDAEIKRLHDALEKSKEELSLIKAKAAENLGAEEAEVFEAHLTILSDPELIGNIEDKIKNDTINAEEATKEVTDNFISMFEAMTDNAYMQERAADIRDVTKRLMSHLLGVELPNPALIDSEVVIVAHDLTPSDTAQLDRRYVKGFITDIGGRTSHSAIMSRTLEIPAVVGSEKATTSVKQGEMMIVDGLTGDAIIAPTDDEIKAYQQKGEEFKAQKAEWEKLKNEKTVSKDGVHFDLAANIGTPDDLQGVLDNGGEAVGLFRSEFLYMNASELPSEDEQFEAYKKVVEGMNGKQVVVRTMDIGGDKELPYLPLPEEMNPFLGYRAIRISLDRTDLFRTQLRALLRASAFGKLAIMFPMIATVAEFKKARAIYDDERQKMVDAGQEVGEIQVGMMMEIPAAAMIADKLAKYVDFFSIGTNDLIQYSFAADRGNEKVSYLYQPYNPSLLRLIKQTIDASHAEGKWTGMCGEMAGDQIAVPILMGLGLDEFSMSATSILKTRSLMKKLTTDDMKKLAEKAVTEAETNEDVIKLVQETVDNI
>NZ_CP028259.1|WP_002833902.1|1580285_1580552_+|phosphocarrier-protein-HPr
MEKRDFHVIAETGIHARPATLLVQSASKFNSDIQLTYKDKSVNLKSIMGVMSLGVGQGADVTISADGDDEADAIAALEDTMKKEGLSD
>NZ_CP028259.1|WP_002833903.1|1579951_1580140_+|hypothetical-protein
MRDYLQLLNDLKDGSIKELKITAEEFQDFQPRFMEFPERKQVIGKADRGGIVVYHFERIKDK
>NZ_CP028259.1|WP_029257840.1|1577527_1579747_-|ATP-dependent-Clp-protease-ATP-binding-subunit
MLCQNCQKNEASIHLYTNVNGQRTEVNLCQNCYQLLKNQRNNNINRNGGARMAQDPFGFGNLDDIFRAMQGGNMGQPENLYGQQVPPTQPGGGNGSGGNPNNRGNGGSLLSQYGLNLTDLAKQGKIDPVIGRDSEIERVIEILNRRTKNNPVLIGEAGVGKTAVVEGLAQRIVEGSVPQKLVNKQIVRLDVVSLVQGTGIRGQFEQRMQQLMKEVQANKDMVVFIDEIHEIVGAGNAEGGMDAGNVLKPALARGDFQLVGATTLKEFRDIEKDAALARRLQPVQVDEPSEEEAIKILKGIQKKYEDYHHVHYTDDAIEAAVKLSKRYIQDRFLPDKAIDLLDEAGSKKNLTINIADPETIQKKIDEAEAQKKAALQSEDYEKAAYYRDQVSKLEKNKDGATSSEEQPTVTEEDMEKIIETKTDIPVGDLQKQEQEQLQNLSENLKDHVIGQDEAVDKISRAIRRNRIGLNGTGRPIGSFLFVGPTGVGKTELAKQLAQQLFGSKDSMIRFDMSEYMEPHSISKLIGSPPGYVGYEEAGQLTEQVRRHPYSLVLLDEVEKAHPDVMHMFLQILDDGRLTDSQGRTVSFKDTIIIMTSNAGTGDVQADVGFGAAAQGKTHSVLDKLGNYFKPEFLNRFDDIVEFQALTKENLMQIVDLMIADVNSMLATQGLHVDVTKPVEERLVDLGYNPKMGARPLRRVIQEQIEDRIADFYLDHPAEKQLNAKIKDDQIEITGAPKKD
>NZ_CP028259.1|WP_002833905.1|1577110_1577473_+|DUF1634-domain-containing-protein
MNAKKQEMQHVELVIGRVLQVGVYISALVILLGIGLWLFKNGSGYSGALPTRITPIFHGVLAFKPYAVLMFGIFLLILTPVLRVIVSIYAFAKEGDRLYVVITTIVLVILIIGMAIGYRG
>NZ_CP028259.1|WP_002833906.1|1576265_1577111_+|sulfite-exporter-TauE/SafE-family-protein
MASHLIILLLVGLMAGIFGAILGIGGGMIITPVLTVAMGLDIKYAIGASIIAVIATSSGATIAYLKDEMLNLRVAMFLEIATTVGAIVGAIMTGIFNSTVLFVLFGSFLVFSSWNMYRKLRRGGGEEGSTKNDRLANQLNLNGSYYDKALKKNVDYQVENVPGGSAVMFGAGLASGLLGIGSGAFKVMAMDNIMKMPLKPSSATSNLMMGVTAAASAMVYFFNGSIHADIAGPLAIGILFGAQLGSRIMQHLQPRWIRMIFIPVLLYMGLQMILKGFGVNI
>NZ_CP028259.1|WP_141822526.1|1594148_1595882_+|pyruvate-oxidase
MTEKINASDAMIKVLESWGVHNVYGLPGGSFDSTMNALYNRKSTINYVQVRHEEVGALAAVGEAKVTGKLGVTFGSAGPGAVHLLNGLYDAKHDHMPVLALVGQVPTTLMNTDYFQELNENPIFTDVAVYNRTVMTAEQMPHVVDEAIRQAYKYSGVAVVTIPKDLGWQPIEDNYVSSANLYQAPILPEPDVKQVDEALEILSNAKHPVMYIGQGTRGAGSDIIALSEKLHIPIVTSALAKGIVPDSYKANMGSAGRVATKPGVEALQAADAVMFVGSDFPFQPYFVAPDAKYIQVDIDASKFGRRHVVDLAILADSHKFLKVMLEKAETTAESKWYKAALENKKNWEEWKNSFVGQQDTPLNVENVFAKINALATDDAIFQVDVGNVTIDGMRFLKADQAQRFTTSGWYATMGYALPAAIGAQAEYPDRQVWSISGDGGYAMVMQDVLTQVKYHMPIINVILTNESLGFIEAEQDDSKQPHSGVDLIDADYGTSAQALGAEGFEVRTYDELEQAFEKAKDRKGPVVIDVKITNLRPLPVEQLLLDKETQDPEAVEQFVKKYHAESLIPFRKLLEEA
>NZ_CP028259.1|WP_141822528.1|1595951_1596683_-|hypothetical-protein
MNKINLPKFNYPIEKKSYLPAINALLLSVVPWYLSSHFSSEIFSKHLSIQILFFLATFMVNFLTIDRLTNKTNLRLMAPLAIIPILTFIILLFSENTYVALLGLLSFVPFLTTFLPFEQKNGVGLLTFSLSVGTLAPLAFFYIRNGFVTSILLKMGLLLSLMIIVILFAIFIKTSFKFAIFALALTLIIMIFAFILLKSWTALIYPILAVFSWFIPKLHLPRNFTLLVLIALIGLASFFITIN
>NZ_CP028259.1|WP_002833742.1|1596855_1598046_+|methionine-adenosyltransferase
MSERHLFTSESVSEGHPDKIADQISDSILDELLKNDPDARVACETTVTTGLVVVVGEISTTAYIDIQKVVRKTIKDIGYVGGEYGFDGENCAVIVAIDEQSPDIAQGVDDSLETREGHEDRLNQIGAGDQGLMFGYATNETEELMPLPIMLSHHLMQRIAKLRKEQVISYLRPDAKAEVTVEYDDNDHPVRVDTVVLSTQHDPDVTLEQIRQDVIEQVIKAVIPATLLDENTNFYINPTGRFVIGGPQGDAGLTGRKIIVDTYGGAARHGGGAFSGKDATKVDRSASYAARYIAKNIVAAKLAERVEVQIAYAIGVAEPVSVMVDTFGTGTVSEEKLTQAVRKIFDLRPAGIIEMLDLKRPIYKQTAAYGHFGRTDVELPWEKTDKVEALNDFFKN
>NZ_CP028259.1|WP_060743924.1|1598120_1599587_+|MFS-transporter
MEKKQTNVVVVTVAIFVATFMSAIEGTIVSTAMPTIVGDLHGVSLMNWVISIFLLTNAIFTPIYGKLSDIFGRKRVFIFGIIIFLIGSMLSGMAHSMGFLILWRALQGIGAGSIMPVSNTIIADIYPIEKRAKVMGLNGSAWGIASIIAPLLGGFIVDNLSWHWIFFINLPIGIITIFLIQFFLKEEVSVHSKKIDYLGSFWLMVALLGLMYGFQLMGESSFSWITLVISFVIFIVGAGLFIRQEKRAEDPIIFLDLFNNRTFVIQNVATMLVSGLLIGFEVYLPSWTQGILGVPASLAGFAVTPSSILWIFGSFLAGRMIVKLKANQILTISLSILAVGSLLLALVPASTPFLAFFFIAAILGVGFGITITSTLVISQQLVTKDRIGVATSFNTLAKTLGQTIMMSVFGIIMNGTMNAGVKANPKINMDMMNKVINPQTAKTLPETLLPTLRNVLYQALHNIYIGCFILIVVALIINAFDRRFKDNI
>NZ_CP028259.1|WP_060743925.1|1599624_1600197_-|16S-rRNA-(cytosine(1402)-N(4))-methyltransferase
MLDNAMQYSHQLLTEIVQPGDVVIDATMGNGHDTLFLSELVQSTGRVFSFDVQKAALEQTRALFEHQHQTLINVELIHASHDQIDHYVTEPITGAIFNLGYLPGGDKSIITHPTSTISAVQQSLNQLKIGGRIILVCYYGHPGGQEELQQLLSFVAELDQHHYSCLRYEFINQINNPPILLCIERKKKWI
>NZ_CP028259.1|WP_011673186.1|1600189_1600822_-|phosphatase-PAP2-family-protein
MHSRKYTHLLINILPTLLFILIVSLVIFKPSWVHAYDNSISSLVQSVRTPGFNQVVSIYTQLGNSIPYIIISLIVCLILILKHLKKAALFLACNIVLGNGLNHLIKQIIQRQRPEFRLISIGGYSFPSGHSVAAMVLFGSLIFITFQVVHHQLKRNLLALIYLILMLGIGLSRIYLNVHFPTDVTAGFLLGLIVLQFTTYLFYGRKIKNA
>NZ_CP028259.1|WP_160208561.1|1601167_1603585_+|leucine--tRNA-ligase
MAYNHKDIEQKWQQFWSDNETFKTVEDADKPKYYALDMFPYPSGQGLHVGHPEGYTATDIMSRMKRMQGYKVLHPMGWDAFGLPAEQYAMKTGNNPRDFTAKNIQNFKRQIQSLGFSYDWSREVNTTDPAYYKWTQWIFEQLYKKGLAYEKETLVNWAPDLMGGTVVANEEVVDGKTERGGFPVYRKPMKQWILKITAYADRLIDDLDLVDWPDSIKEMQKNWIGRSVGASVFFNVEDSEKQIEVFTTRPDTLFGATYLVISPEHDLVDQITTPESKAAVEEYKKAVATKSDLERTDLNKDKTGVFTGAYAVNPVNGKKIPVWISDYVLASYGTGAVMAVPAHDGRDYEFAKKFKIDMVPVYEGGNLEDGVLDSEGGLINSGFLDGMDKQTAIDTMISWLEEHGVGHKKVNYRLRDWVFSRQRYWGEPIPVIHWEDGETTLIPEDELPLRLPAATDIRPSGTGESPLANLDDWVNVVDENGRKGRRETNTMPQWAGSSWYFLRYVDPKNDQKIADEDLLKEWLPVDLYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPFQKLVNQGMILGSNHEKMSKSKGNVVNPDDIVERFGADTLRLYEMFMGPLTESVAWSEDGLNGSRKWIDRVWRLMIDDENQLRDHIVTENDGILDMIYNQTVKKVTDDYENMRFNTAISQMMVFVNEAYKADKLPAVYMEGLVKMLAPIIPHVAEELWSLLGHEGGISYAEWPTYDESKLVEATVQVILQVNGKVRSKITVDKDIAKEELEKLALADAKIQQWTADKTVRKVIVIPNKIVNIVVG
>NZ_CP028259.1|WP_060743927.1|1603788_1605474_+|polysaccharide-biosynthesis-protein
MDKQSEMDNSESLYMGSQPLRDNSGKSSSKAKMLEGSAWMTAGSIFSRILGAIYIIPWVIWFGVYSDQANALFTKGYNIYSFFLIAAIAGIPSAISKQVSHYNAINEFALGQRLYKRGLLLSVGTGIICAAILYFGAPFLKDGDPNVITVLHALAWAVLVIPTMSLTRGFFQGYQEMGPSAVSQFIEQLARVIYMLTTAYFIMGKSGQGDWVYGVSQSTFAAFIGALGGLLVLGIYFIKYRKRLSYLSQHSANELVVSTSTLYKEIIAQAVPFIIIGSAITIFQLIDQYTFFRIMNAVSDYSTAVLNNMYAIFAFNANKLVMIVISLASAMAVTSVPILSEAKTRGDRAEISRQVTDSILLFAFLMIPAALGMAAVAQPAYTLFYHLSDVGTAILQFNSYVAIVLGLFTVISAIMQGIGENVLAVKYFCVGMIVKFIFQFPMVALFSAVGSLISTAIGFMVVNWLILRHINLEYGLDYRRINTFIGKIITYAFGTFLIAMVVTNGLYIVMDPASKVQSLLVIAAAVVLGGAFYLYFVLKSRLADEIVGARAAGLRRMLRIS
>NZ_CP028259.1|WP_060743928.1|1605482_1606202_+|16S-rRNA-pseudouridine(516)-synthase
MRVDKFLHDMNMGTRTQIRKMIKDKLIFVNDTVVKTGRVKVDPMIDEVRLKDQVIEYQQYFYFMMNKPLGVLTATEDRKQKTVMDLFNKVDLRSDLFPVGRLDKDTQGLLLITNNGQLAHDLLAPERHVDKTYEAVVTGKITDQAVEEFQKGITLKDGTTLKPAQLIIEHYSELDDQTVVKVVLKEGKYHQVRRMFGSLGEKVVTLRRTSFGPLELDVGLLPGTYRELTDDEINRLVEG
>NZ_CP028259.1|WP_141822530.1|1606224_1607064_-|NAD(P)H-hydrate-dehydratase
MLKINQDGLNDLWPVRSNDSHKGSYGRILIVAGNDQYGGAGILSSSAAVYVGGGLVTLATDKSNFTAVRSTLAEVMLLDFLDFDALKAALKKSTGVVIGPGLGTNATSLKILKFVLDHVQPQTPLVIDGSAIDLIATHQIQVDHPQTIFTPHQMEWQRLSGIKIADQAPTLNQRAVDHLKAIVVLKHYETEIYAPHTDFRQIMAGNPGMATGGSGDALTGVIIALVNQVDSLALGVTLGTFLHSYTADQIYQKEAVVLPHRLIRRLPFTLKQLQKNKLL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1075 : 65518

Lactobacillus_phage(36.36%)

head,plate,tail,capsid,terminase,portal,holin,tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_160208351.1\|1075_2275_+	ATP-binding protein	C7BGE8	Burkholderia_phage	1.8e-30	27.4
WP_160208353.1\|2271_3015_+	hypothetical protein	NA	NA	NA	NA
WP_160208355.1\|3212_3818_+\|terminase	terminase small subunit	H9A0M8	Staphylococcus_phage	4.3e-12	43.3
WP_160208357.1\|3801_5073_+\|terminase	PBSX family phage terminase large subunit	Q6SE84	Lactobacillus_prophage	2.6e-168	66.5
WP_160208598.1\|5153_6476_+\|portal	phage portal protein	A0A0A1ER87	Lactobacillus_phage	1.3e-138	56.7
WP_160208359.1\|6459_7422_+\|head	phage head morphogenesis protein	A0A0P0ID43	Lactobacillus_phage	4.0e-73	47.3
WP_160208361.1\|7424_7826_+	hypothetical protein	NA	NA	NA	NA
WP_160208363.1\|7828_8197_+	hypothetical protein	NA	NA	NA	NA
WP_160208365.1\|8301_8964_+	DUF4355 domain-containing protein	Q6SED3	Lactobacillus_prophage	2.2e-09	30.5
WP_160208367.1\|8976_9294_+	hypothetical protein	A0A0N7IR89	Lactobacillus_phage	5.6e-40	79.8
WP_160208369.1\|9297_10317_+\|capsid	major capsid protein	A0A0P0IZJ7	Lactobacillus_phage	7.3e-158	81.7
WP_160208599.1\|10334_10601_+	hypothetical protein	NA	NA	NA	NA
WP_158190617.1\|10613_10985_+	hypothetical protein	A0A0P0IV23	Lactobacillus_phage	6.0e-25	52.0
WP_160208370.1\|10989_11292_+	hypothetical protein	A0A0N7IR97	Lactobacillus_phage	2.2e-17	46.5
WP_160208372.1\|11284_11656_+	hypothetical protein	A0A0P0I3G7	Lactobacillus_phage	2.2e-11	37.8
WP_160208373.1\|11656_12064_+	hypothetical protein	A0A0A1EN91	Lactobacillus_phage	2.7e-18	35.7
WP_160208375.1\|12081_12678_+\|tail	phage major tail protein, TP901-1 family	A0A0A1ELH3	Lactobacillus_phage	5.1e-50	54.0
WP_160208377.1\|12755_13034_+	hypothetical protein	NA	NA	NA	NA
WP_159234056.1\|13113_13452_+	hypothetical protein	A0A097BY80	Leuconostoc_phage	7.6e-27	56.6
WP_141822627.1\|13499_13886_+	hypothetical protein	A0A1B0Y2Q4	Lactobacillus_phage	2.9e-22	52.1
WP_160208378.1\|13878_17022_+\|tail	phage tail tape measure protein	A0A097BYC3	Leuconostoc_phage	2.4e-122	57.5
WP_160208380.1\|17228_17993_+\|tail	phage tail protein	A0A286QN36	Streptococcus_phage	1.5e-38	38.0
WP_160208382.1\|17992_20998_+	peptidoglycan DD-metalloendopeptidase family protein	Q6SEC2	Lactobacillus_prophage	7.2e-145	37.4
WP_160208384.1\|20981_21428_+	hypothetical protein	NA	NA	NA	NA
WP_160208386.1\|21431_23288_+\|plate	BppU family phage baseplate upper protein	O03968	Lactobacillus_phage	5.1e-117	40.7
WP_160208387.1\|23296_24049_+	hypothetical protein	NA	NA	NA	NA
WP_160208389.1\|24048_24369_+	DUF2977 domain-containing protein	NA	NA	NA	NA
WP_160208391.1\|24368_24500_+	XkdX family protein	NA	NA	NA	NA
WP_146419683.1\|24549_24834_+	hypothetical protein	NA	NA	NA	NA
WP_160208393.1\|24833_25085_+\|holin	holin	NA	NA	NA	NA
WP_160208394.1\|27304_27994_+	hypothetical protein	NA	NA	NA	NA
WP_160208404.1\|27996_29136_+	ImmA/IrrE family metallo-endopeptidase	A0A0A7RTT7	Clostridium_phage	6.7e-35	31.9
WP_128886915.1\|29773_31150_+	amino acid permease	NA	NA	NA	NA
WP_128886914.1\|31309_32476_+	hydroxymethylglutaryl-CoA synthase	NA	NA	NA	NA
WP_060743702.1\|32515_33115_-	hypothetical protein	NA	NA	NA	NA
WP_002833597.1\|33193_33823_-	transcriptional repressor LexA	A0A1B2APZ1	Phage_Wrath	1.2e-12	45.1
WP_002833598.1\|33956_34205_+	DUF896 domain-containing protein	NA	NA	NA	NA
WP_002833599.1\|34275_34497_+	YneF family protein	NA	NA	NA	NA
WP_029257926.1\|34508_35153_-	1-acyl-sn-glycerol-3-phosphate acyltransferase	NA	NA	NA	NA
WP_002833602.1\|35227_35983_+\|tRNA	tRNA1(Val) (adenine(37)-N6)-methyltransferase	NA	NA	NA	NA
WP_002833603.1\|35963_36251_+	GIY-YIG nuclease family protein	NA	NA	NA	NA
WP_060743700.1\|36371_37367_+	D-2-hydroxyacid dehydrogenase	M1I4S0	Paramecium_bursaria_Chlorella_virus	6.7e-47	32.9
WP_002833605.1\|37518_38301_+	30S ribosomal protein S2	NA	NA	NA	NA
WP_060743699.1\|38416_39295_+	elongation factor Ts	NA	NA	NA	NA
WP_002833607.1\|39448_40174_+	UMP kinase	NA	NA	NA	NA
WP_060743698.1\|40173_40734_+	ribosome recycling factor	NA	NA	NA	NA
WP_011673316.1\|40991_41741_+	isoprenyl transferase	R9W0U9	Flavobacterium_phage	3.0e-23	41.3
WP_041527001.1\|41751_42537_+	phosphatidate cytidylyltransferase	NA	NA	NA	NA
WP_060743697.1\|42560_43823_+\|protease	RIP metalloprotease RseP	NA	NA	NA	NA
WP_060743696.1\|43850_45566_+\|tRNA	proline--tRNA ligase	A0A2K9L6B6	Tupanvirus	2.2e-05	23.6
WP_160208406.1\|45659_49973_+	PolC-type DNA polymerase III	A0A0K2SUJ2	Clostridium_phage	1.8e-19	35.1
WP_002833614.1\|50092_50569_+	ribosome maturation factor RimP	NA	NA	NA	NA
WP_002833615.1\|50582_51671_+	transcription termination/antitermination protein NusA	NA	NA	NA	NA
WP_011673321.1\|51692_51986_+	YlxR family protein	NA	NA	NA	NA
WP_060744010.1\|51986_52289_+	50S ribosomal protein L7	NA	NA	NA	NA
WP_060744011.1\|52301_55058_+	translation initiation factor IF-2	A0A2H4UTS4	Bodo_saltans_virus	9.3e-22	25.1
WP_002833619.1\|55074_55425_+	30S ribosome-binding factor RbfA	NA	NA	NA	NA
WP_011673323.1\|55563_56463_+\|tRNA	tRNA pseudouridine(55) synthase TruB	NA	NA	NA	NA
WP_060744012.1\|56466_57411_+	riboflavin biosynthesis protein RibF	A0A1V0SD03	Indivirus	9.9e-08	31.0
WP_002833622.1\|57518_58559_+	heat-inducible transcriptional repressor HrcA	NA	NA	NA	NA
WP_060744013.1\|58548_59139_+	nucleotide exchange factor GrpE	NA	NA	NA	NA
WP_011673326.1\|59164_61024_+	molecular chaperone DnaK	A0A2P1EIW2	Megavirus	5.3e-138	47.2
WP_060744014.1\|61120_62245_+	molecular chaperone DnaJ	A0A0P0YNN4	Yellowstone_lake_phycodnavirus	1.3e-22	33.2
WP_002833626.1\|62348_62576_-	DUF378 domain-containing protein	NA	NA	NA	NA
WP_141822651.1\|62704_63175_-	tryptophan-rich sensory protein	NA	NA	NA	NA
WP_160208407.1\|63411_63894_+	QueT transporter family protein	E7DN70	Pneumococcus_phage	6.4e-11	35.0
WP_060744015.1\|63910_64132_+	DUF2829 domain-containing protein	G3MBC9	Bacillus_virus	3.9e-08	32.6
WP_141822655.1\|64132_64873_+	3-oxoacyl-ACP reductase	Q06VL0	Trichoplusia_ni_ascovirus	4.9e-18	31.3
WP_002833631.1\|64996_65518_+	DUF4373 domain-containing protein	A0A0P0HRQ2	Lactobacillus_phage	4.0e-43	57.1

DBSCAN-SWA_2

179227 : 188845

Staphylococcus_phage(37.5%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060743609.1\|179227_180073_-	DegV family protein	A0A0N9SI50	Staphylococcus_phage	2.3e-16	34.4
WP_023440467.1\|180309_181047_-	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.3e-34	40.4
WP_060743608.1\|181043_182495_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_029258026.1\|182616_183102_-	dihydrofolate reductase	A0A0N9S8H6	Staphylococcus_phage	4.6e-25	39.6
WP_011673474.1\|183130_184081_-	thymidylate synthase	A0A0N9SH48	Staphylococcus_phage	3.4e-117	62.7
WP_060743607.1\|184093_185971_-	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	2.2e-51	30.5
WP_060743606.1\|185973_187182_-\|tRNA	CCA tRNA nucleotidyltransferase	G3MAR3	Bacillus_virus	3.8e-36	30.5
WP_002833200.1\|187435_188320_+	YitT family protein	M1Q1P6	Streptococcus_phage	2.1e-52	38.1
WP_002833201.1\|188374_188845_-	nucleoside deoxyribosyltransferase	A0A1G5S9Z4	Enterococcus_phage	3.8e-16	40.1

DBSCAN-SWA_3

552842 : 561406

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060743838.1\|552842_553424_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	6.7e-23	35.2
WP_060743839.1\|553420_554470_-	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D8KLC2	Synechococcus_phage	5.2e-58	40.2
WP_023440671.1\|554469_555939_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.1e-56	33.3
WP_160208454.1\|555923_558131_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.7e-146	41.6
WP_060743842.1\|558148_558823_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_011673681.1\|558825_559080_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_160208455.1\|559072_559801_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D7SLB8	Cyanophage	1.1e-41	43.0
WP_060743844.1\|559800_560940_-	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_011673684.1\|560923_561406_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	2.6e-20	42.9

DBSCAN-SWA_4

570235 : 579102

Streptococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060743848.1\|570235_571252_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	4.3e-33	30.8
WP_002833272.1\|571251_571587_-	hypothetical protein	NA	NA	NA	NA
WP_002833271.1\|571602_572232_-	dTMP kinase	M1PSC7	Streptococcus_phage	2.0e-52	52.7
WP_002833270.1\|572396_572996_-	recombination protein RecR	NA	NA	NA	NA
WP_002833269.1\|573022_573337_-	YbaB/EbfC family nucleoid-associated protein	NA	NA	NA	NA
WP_060743849.1\|573352_575098_-	DNA polymerase III subunit gamma/tau	A0A1U9WR94	Streptococcus_virus	2.8e-56	48.4
WP_060743850.1\|575309_575795_-	nucleoside deaminase	A0A2H4PQS8	Staphylococcus_phage	1.8e-05	31.6
WP_011673695.1\|575787_576393_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_011673696.1\|576604_576835_+	glutaredoxin-like protein NrdH	A0A0M7REK7	Lactobacillus_phage	8.0e-12	48.1
WP_011673697.1\|576936_579102_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A8E2R1	Enterococcus_phage	3.9e-249	59.9

DBSCAN-SWA_5

802305 : 810561

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060743552.1\|802305_803562_-	D-alanyl-D-alanine carboxypeptidase	B6DZZ7	Stx2-converting_phage	3.8e-07	23.1
WP_011673829.1\|803742_804879_-	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	2.8e-25	25.8
WP_002834114.1\|804890_805580_-	response regulator transcription factor	W8CYM9	Bacillus_phage	5.7e-37	37.3
WP_060743551.1\|805662_806160_-	methylated-DNA--[protein]-cysteine S-methyltransferase	A0A2P1EI66	Megavirus	1.3e-14	38.1
WP_011673831.1\|806290_807433_-	guanosine monophosphate reductase	A0A1V0SHK8	Klosneuvirus	2.4e-64	34.0
WP_023440817.1\|807454_808159_-	DUF1129 domain-containing protein	NA	NA	NA	NA
WP_060743550.1\|808187_809294_-	redox-regulated ATPase YchF	NA	NA	NA	NA
WP_002834122.1\|809510_809696_-	DUF951 domain-containing protein	NA	NA	NA	NA
WP_023440818.1\|809709_810561_-	ParB/RepB/Spo0J family partition protein	S5VTK0	Leptospira_phage	2.1e-12	34.9

DBSCAN-SWA_6

1012686 : 1059127

Streptococcus_phage(28.57%)

bacteriocin,holin,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060744138.1\|1012686_1012965_-\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA
WP_011672822.1\|1012979_1013162_-\|bacteriocin	bacteriocin	NA	NA	NA	NA
WP_146419512.1\|1013593_1014898_+	GHKL domain-containing protein	NA	NA	NA	NA
WP_060744136.1\|1014916_1015663_+	response regulator transcription factor	NA	NA	NA	NA
WP_132981348.1\|1015826_1016741_-	zinc ABC transporter solute-binding protein	NA	NA	NA	NA
WP_158190262.1\|1016811_1016931_-	putative metal homeostasis protein	NA	NA	NA	NA
WP_011672828.1\|1017517_1017910_+	hypothetical protein	NA	NA	NA	NA
WP_128887238.1\|1018001_1018520_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_060744134.1\|1018749_1020561_+	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	3.9e-69	31.6
WP_138428183.1\|1020815_1022111_+	PTS sugar transporter subunit IIC	NA	NA	NA	NA
WP_055126608.1\|1022094_1022958_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_060744132.1\|1023065_1023716_-	hypothetical protein	NA	NA	NA	NA
WP_060744130.1\|1025101_1025536_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_141822350.1\|1025718_1026996_-	oligosaccharide MFS transporter	NA	NA	NA	NA
WP_141822352.1\|1027008_1027983_-	family 43 glycosylhydrolase	NA	NA	NA	NA
WP_138428181.1\|1028247_1029138_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_138428180.1\|1029313_1029541_+	hypothetical protein	NA	NA	NA	NA
WP_141822354.1\|1029857_1030109_-	hypothetical protein	NA	NA	NA	NA
WP_138428178.1\|1030372_1030636_-	hypothetical protein	NA	NA	NA	NA
WP_138428177.1\|1030868_1031216_-	type II toxin-antitoxin system PemK/MazF family toxin	NA	NA	NA	NA
WP_099300158.1\|1031215_1031482_-	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	NA	NA	NA	NA
WP_160208607.1\|1031948_1032179_-	hypothetical protein	NA	NA	NA	NA
WP_160208493.1\|1033560_1034369_-\|transposase	IS3 family transposase	Q6J1X2	Lactobacillus_phage	6.8e-90	100.0
WP_099300094.1\|1036330_1036807_-	hypothetical protein	NA	NA	NA	NA
WP_160208495.1\|1038635_1038764_-\|holin	putative holin-like toxin	NA	NA	NA	NA
WP_160208497.1\|1038947_1041215_-	excinuclease ABC subunit UvrA	A0A1B1IVR3	uncultured_Mediterranean_phage	8.8e-127	30.9
WP_160208499.1\|1041689_1042475_-	cyclase family protein	NA	NA	NA	NA
WP_160208501.1\|1042488_1043835_-	APC family permease	NA	NA	NA	NA
WP_055126633.1\|1043999_1045118_-	5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase	A0A218MNE0	uncultured_virus	1.3e-75	42.1
WP_011673098.1\|1045779_1045971_-	hypothetical protein	NA	NA	NA	NA
WP_160208502.1\|1046098_1047628_+	multicopper oxidase domain-containing protein	NA	NA	NA	NA
WP_003690687.1\|1047667_1049041_+	MFS transporter	NA	NA	NA	NA
WP_132981463.1\|1049194_1049560_-	hypothetical protein	NA	NA	NA	NA
WP_099267087.1\|1050830_1052945_+\|protease	ATP-dependent Clp protease ATP-binding subunit	K4FB40	Cronobacter_phage	2.4e-118	39.0
WP_011669001.1\|1054248_1054488_-	hypothetical protein	NA	NA	NA	NA
WP_011669002.1\|1054491_1055277_-	ParA family protein	A0A1X9I765	Streptococcus_phage	5.9e-38	37.2
WP_013727997.1\|1055468_1056377_+	magnesium transporter CorA family protein	NA	NA	NA	NA
WP_132981467.1\|1057608_1057977_+	hypothetical protein	NA	NA	NA	NA
WP_160208504.1\|1058137_1059127_+\|transposase	IS30 family transposase	Q9MBM9	Staphylococcus_prophage	1.4e-57	40.2

DBSCAN-SWA_7

1443138 : 1450756

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_141822485.1\|1443138_1444254_+	peptide chain release factor 2	B5LLF2	Mycobacterium_phage	1.9e-05	47.1
WP_002834460.1\|1444265_1444970_+	response regulator transcription factor	W8CYM9	Bacillus_phage	6.9e-38	37.3
WP_060743354.1\|1444941_1446327_+	sensor histidine kinase	W8CYF6	Bacillus_phage	2.2e-27	33.8
WP_060743355.1\|1446488_1447370_+	phosphate ABC transporter substrate-binding protein PstS family protein	H6WG65	Cyanophage	2.7e-07	25.5
WP_060743356.1\|1447369_1448278_+	phosphate ABC transporter permease subunit PstC	NA	NA	NA	NA
WP_002834456.1\|1448278_1449166_+	phosphate ABC transporter permease PstA	NA	NA	NA	NA
WP_060743357.1\|1449183_1449984_+	phosphate ABC transporter ATP-binding protein	Q6GZ03	Mycoplasma_phage	3.4e-09	42.0
WP_023440049.1\|1449997_1450756_+	phosphate ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.7e-18	30.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP028260

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP028259

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection