CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP017146	Marisediminicola antarctica strain ZS314 chromosome, complete genome	13 crisprs	csa3,cas3,RT,DEDDh,WYL	2	5	2	0

1. NZ_CP017146

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP017146_1

• CRISPR_ID: NZ_CP017146_1
• CRISPR_location: 440363-440428
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP017146_1

Consensus_repeat	Method
GACCGCGGCGAGCTGGCTGTGAGGA	CRISPRCasFinder

spacers of NZ_CP017146_1

>1.1|440388|16|NZ_CP017146|CRISPRCasFinder
TCGGCAGCAAGGGGCT

CRISPR arrays and Neighbor proteins around NZ_CP017146_1

CRISPR arrays

The CRISPR arrays of NZ_CP017146_1

>merge|NZ_CP017146|1|440363-440428|CRISPRCasFinder
GACCGCGGCGAGCTGGCTGTGAGGATCGGCAGCAAGGGGCTGACCGCGATGAGCTGACCGCGGCGA

>NZ_CP017146|1|1|440363-440428|CRISPRCasFinder
GACCGCGGCGAGCTGGCTGTGAGGA	TCGGCAGCAAGGGGCT
GACCGCGATGAGCTGACCGCGGCGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017146.1|WP_161884954.1|444523_445894_+|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl|CDD|237001
NZ_CP017146.1|WP_161884949.1|433623_434679_+|iron-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270261
NZ_CP017146.1|WP_161884955.1|445975_446962_+|zinc-ABC-transporter-solute-binding-protein	unknown	unknown	gnl|CDD|238502
NZ_CP017146.1|WP_161884946.1|431130_431655_-|low-molecular-weight-phosphotyrosine-protein-phosphatase	unknown	unknown	gnl|CDD|319971
NZ_CP017146.1|WP_161884947.1|431787_432102_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161884956.1|447872_448763_+|metal-ABC-transporter-permease	unknown	unknown	gnl|CDD|224033
NZ_CP017146.1|WP_161884952.1|440575_440983_-|phage-holin-family-protein	unknown	unknown	gnl|CDD|377198
NZ_CP017146.1|WP_161884950.1|436405_437842_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|226361
NZ_CP017146.1|WP_161884948.1|432091_433516_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161884957.1|448773_449184_+|transcriptional-repressor	unknown	unknown	gnl|CDD|133478
NZ_CP017146.1|WP_161887306.1|447108_447873_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|213202
NZ_CP017146.1|WP_161887305.1|442342_443440_+|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	unknown	unknown	gnl|CDD|213783
NZ_CP017146.1|WP_161884943.1|428739_429384_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161884951.1|438248_440174_-|DUF222-domain-containing-protein	unknown	unknown	gnl|CDD|238038
NZ_CP017146.1|WP_161887304.1|441137_442247_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|179559
NZ_CP017146.1|WP_161884958.1|449267_451661_+|phosphoenolpyruvate-synthase	unknown	unknown	gnl|CDD|235809
NZ_CP017146.1|WP_161884945.1|429751_431134_-|adenylosuccinate-lyase	unknown	unknown	gnl|CDD|236452
NZ_CP017146.1|WP_161884953.1|443436_444504_+|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl|CDD|223101
NZ_CP017146.1|WP_161884944.1|429380_429647_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161887303.1|434894_436409_+|iron-ABC-transporter-permease	unknown	unknown	gnl|CDD|224099

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP017146.1|WP_161884954.1|444523_445894_+|2-oxo-acid-dehydrogenase-subunit-E2	gnl|CDD|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	7.18383e-155
NZ_CP017146.1|WP_161884949.1|433623_434679_+|iron-ABC-transporter-substrate-binding-protein	gnl|CDD|270261	cd13543, PBP2_Fbp, Substrate binding domain of ferric iron transporter, a member of the type 2 periplasmic binding fold superfamily. The periplasmic iron binding protein plays an essential role in the iron uptake pathway of Gram-negative pathogenic bacteria from the Pasteurellaceae and Neisseriaceae families and is critical for survival of these pathogens within the host. This periplasmic protein (Fbp) has high affinities for ferric iron and serves as the primary receptor for transport. After binding iron with high affinity, Fbp interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ferric iron-binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	5.85204e-120
NZ_CP017146.1|WP_161884955.1|445975_446962_+|zinc-ABC-transporter-solute-binding-protein	gnl|CDD|238502	cd01020, TroA_b, Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains. In addition, these proteins sometimes have a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence).	7.01579e-65
NZ_CP017146.1|WP_161884946.1|431130_431655_-|low-molecular-weight-phosphotyrosine-protein-phosphatase	gnl|CDD|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	4.41488e-60
NZ_CP017146.1|WP_161884956.1|447872_448763_+|metal-ABC-transporter-permease	gnl|CDD|224033	COG1108, ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism].	4.05544e-44
NZ_CP017146.1|WP_161884952.1|440575_440983_-|phage-holin-family-protein	gnl|CDD|377198	pfam04020, Phage_holin_4_2, Mycobacterial 4 TMS phage holin, superfamily IV. These proteins are predicted transmembrane proteins with probably four transmembrane spans. The 1.E.40 is represented by the mycobacterial 4 phage holin, but it also contains many cyanobacterial. proteobacterial and firmicute proteins. Holins are encoded within the genomes of Gram-positive and Gram-negative bacteria as well as in those of the bacteriophage of these organisms. The primary function of holins appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis. When chromosomally encoded the enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some may catalyze export of nucleases.	8.81091e-15
NZ_CP017146.1|WP_161884950.1|436405_437842_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	3.13556e-106
NZ_CP017146.1|WP_161884957.1|448773_449184_+|transcriptional-repressor	gnl|CDD|133478	cd07153, Fur_like, Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators. Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.	1.04201e-38
NZ_CP017146.1|WP_161887306.1|447108_447873_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|213202	cd03235, ABC_Metallic_Cations, ATP-binding cassette domain of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-siderophore uptake family suggesting that they share a common ancestor. The best characterized metal-type ABC transporters are the YfeABCD system of Y. pestis, the SitABCD system of Salmonella enterica serovar Typhimurium, and the SitABCD transporter of Shigella flexneri. Moreover other uncharacterized homologs of these metal-type transporters are mainly found in pathogens like Haemophilus or enteroinvasive E. coli isolates.	3.99018e-69
NZ_CP017146.1|WP_161887305.1|442342_443440_+|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	gnl|CDD|213783	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	1.38784e-158
NZ_CP017146.1|WP_161884951.1|438248_440174_-|DUF222-domain-containing-protein	gnl|CDD|238038	cd00085, HNHc, HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.	2.23556e-13
NZ_CP017146.1|WP_161887304.1|441137_442247_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl|CDD|179559	PRK03321, PRK03321, putative aminotransferase; Provisional.	5.55847e-158
NZ_CP017146.1|WP_161884958.1|449267_451661_+|phosphoenolpyruvate-synthase	gnl|CDD|235809	PRK06464, PRK06464, phosphoenolpyruvate synthase; Validated.	0
NZ_CP017146.1|WP_161884945.1|429751_431134_-|adenylosuccinate-lyase	gnl|CDD|236452	PRK09285, PRK09285, adenylosuccinate lyase; Provisional.	0
NZ_CP017146.1|WP_161884953.1|443436_444504_+|alpha-ketoacid-dehydrogenase-subunit-beta	gnl|CDD|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	1.58376e-149
NZ_CP017146.1|WP_161887303.1|434894_436409_+|iron-ABC-transporter-permease	gnl|CDD|224099	COG1178, ThiP, ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism].	1.14049e-81

Protein sequences

>NZ_CP017146.1|WP_161884951.1|438248_440174_-|DUF222-domain-containing-protein
MEQLPNTLRDTADTVAGLGACAGEFTALDDASLFAAQRSVSALRRAVDTYAAWIAAAIAKHSDRALGHAGLAISAGFVSAEALIQSISGSTRAEAAKLVQIGTLLAETEAAEALAAADPTATGGTPTAGAPTAGAPVSDPGSPASPGPATDPAWTVDPRFPVGMPVWQAPIARAVAAGLLSLDGAEAIRRGLGGIDDAVTAEQLTAAAEHLITAINPSNPSNPSNPGNPGNPGNPGSAGAGRVLGADEVQRLARRLRDELDSDGIRRREKEQYDLRAVRKWRTADGMHHGIWHLHPEDGALLDSALSTILSPRRGGPRFIDPEEKAKAQKLVEDPRTDEQILADALIGMIRIATDADPGTMFGSRRPAVRLIITKKDLTTNTTPTTGTSTDASTGTGFIAATRVSTPTSTSTGTGTGVATETGTNASTSTSTSTSTSTASVPGDRTPDVDPLALPASPALTPQPSQSLQPLPPQPPPPPPLPLLPGISADHGWIEGTLDPISIETIQRNLCDTGHIPVLFDDDGQCLNVGHTKRHFTARQRIALATRDGGCMFPSCDRPPSWCEAHHIKHWDRDNGPTNIDNGILLCRRHHLLLHDNHWEITNTNNNYWLQPPTTIDPTQTLIPLPSKTPTITTITRKKAS
>NZ_CP017146.1|WP_161884950.1|436405_437842_+|ATP-binding-cassette-domain-containing-protein
MSRLSMRNVVVGYGVEPVLRGISLEVPNGSLVAIVGPSGCGKTTLLRTIAGLIRARSGEVRLGQRMVTTHGIHLAPEKRRIGWVPQDAALFPHLTVAENIAFGLGGGRRAARRAAGEERVRHLLSMVGLSALADRSPAQLSGGQAQRVALARALASGPEVVLMDEPFGALDPLLRGELRTEVRALLAAEGMTGILVTHDQAEALSIADYVAVMRDGEILQFGTPPEIYDRPATPWVATFVGESVFLPGLWRSGSVVGALGSLEAEWMPAAGTRGNPANGASSRLTLDEGADLDEGAVARGALAYDESGVRHDRQLRSEIRRSGETAPMIVFPAGAAAAAEDVGPGAAGAGACAGAGGATRGAAGVGETASNRAVAPTRPGTPTRAGAPAGPVDDTPVTVLVRPEQLELTSIDGSVLAQGLRATVTAVTYTGHDALLELSLQSGTSCMARVAASGLLPVGAEVTVEVRGRVLAYPRAGD
>NZ_CP017146.1|WP_161887303.1|434894_436409_+|iron-ABC-transporter-permease
MLLLLALVACAIASIPLVYLLVRVGSSGLEDAVTVLGRPRVPQLLLNTVSLAAAVTATCVLVGVPTAFLLARTRLRLRGMWTVLAALPLAVPSYLAAYGWLAAVPGMQGFGASWLVLTLVSTPYVTLPVMAALRAGTTGLDDVARTLGRSAWHAFWLGTWPQIRPATLAGALLVCLYVLSEFGAVALLRFPVLTTAIQQAYGASFNRNYAAILATVLVLLAMIIVIAEQTARGRARRRFGAVTGVARHRIVNLGHWTVPSIALLSVVPALAVGLPVAVLFARLFEAETLRALDPVELGQAILNTLALSIGGAVIAVILALPIGALAARYRGRLVRLIESLGYLALGLPGIVVGLSLVFFSLSVMPALYQTGFVLAFAYGVLFMPKAIGAIRSATAQVPTSLEDVSRTLGYGQLQTWWFVTARLARPGIFAGALLVAVTAMKELPATLLLRPTGTDTLAIELWSRTDVSAYGAAAPYAAALILVAAVPAFLLSGAGRGRVDGTAS
>NZ_CP017146.1|WP_161884949.1|433623_434679_+|iron-ABC-transporter-substrate-binding-protein
MRTLRRGLILSAGVTALALTVAGCAPASDTEPAAPNDAAIESDGELTLYAGRDEALIAPLIEQFTEDTGIEVSARYGSSPELNALLLEEGDNSPAQVFLSQDAGALGSLANADLVSKIPAEFADLIPAGFTSEDDSWIGVTGRARVIAYDTEKLSEDEIPDGVEELTDPKWSGRVGFPPGNASFQSFVTALRVLEGEEDAEAWVEGISKNSPVLTEKNGATLDLVNSGQLDLALINHYYWYEDAAEVGADGMRAQLKFLPGDAGGMVNVTGAAILAGAEGDPDALAFIEYLVSEKAQQFFVENTYEYPLLPGVAAPEGLPELESLVNPQLDLSDLESLEITQELLAQYGLL
>NZ_CP017146.1|WP_161884948.1|432091_433516_+|hypothetical-protein
MSDDLVVGGGGSIAVATVTLFAQAQRLERLERNLEECVRTLGAMDAAAASRLPGTADCRPALEQAARGIDDARALLGLAVVRTGHLAAGLQLSANVYGAGESALAALGERLAGDFAAGLGFLAARLGLVLAPGLLVASSRAALAYAVASTVIPDATRRGTDAAERWGVGQRAILSDPRFVQFARVSIVSVDEFAAGAAGLPLPVVRMLGDDGIGILGIDTTVGAVAAGASVVGALRETPIRIAPVARGTSTRADGFADRAARVPSGRAQVRIDQYSAPGQPDRFEVYLGGTADFSPTSGTEPWDLTSNISALSGEPSGAYRAVADVLNHAGVGAQSPLVVTGYSQGGLVAAQLAASGDYDVRALFTLGAPSGQVDVPRDVPWVAVEHTDDLVPALGGTWARADPVLVRREVFSDGPPPPELAVPAHAAEHYRATAKFIDAANERRLLAAGAEFDAVGRGAERVETTWYRAWRAP
>NZ_CP017146.1|WP_161884947.1|431787_432102_+|hypothetical-protein
MSPTKAEEKMPQGSDSDPWALSVMIASRMLEEQAAALAVMRSRIDRARALAPSGVESEWAGPARRLYDAGLDELHRTISSAQASVDVALADTRRAIDTLAGHVG
>NZ_CP017146.1|WP_161884946.1|431130_431655_-|low-molecular-weight-phosphotyrosine-protein-phosphatase
MSFDRTLHESALFRICFVCTGNICRSPMAEVVFRHLVARQGYDSAISVMSAGTGDWHVGENADDRTVTALTARGYVSGDHRARQFDPDWFDSLDLVVVFDRSQDRILKAWAGSESDRGKVQMLLGFDKAQAPRVDVPDPYYADAAMFDSVLNMIERASSALLDQIKPGIRLETP
>NZ_CP017146.1|WP_161884945.1|429751_431134_-|adenylosuccinate-lyase
MTLPEQPLSPLDGRYRTAVVGLGEHLSEAGLNRARVLVEVEWLIFLTDRELFGAHRLSAEQAASLRSLVDDFGQADIDELASLEATTRHDVKAVEYYVRARLEKLGLSDVAELTHFACTSEDINNLAYALTIGSAVREVWMPALDTVIAGLTDRAVAHRAVPMLAHTHGQPATPTTVGKEFAVFVHRLRRIVVRIEQTEYLGKFSGATGTFAAHVAADSSQDWPELSREFVESLGLVWNPLTTQIESHDWQAELYSAISHANRVLHNLATDIWTYISLGYFTQIPQAGATGSSTMPHKINPIRFENAEANLELSSALLDSLSATLVTSRLQRDLTDSTTQRNVGVALGHSLLALDNLRRGLGEIAVNEVRLAEDLDGNWEILGEAIQTVIRAEITAGTSSISDPYALLKDLTRGRRVGQAELVEFVRALDISDGAKDRLAALTPAGYAGLASKMVGFLDS
>NZ_CP017146.1|WP_161884944.1|429380_429647_+|hypothetical-protein
MSTTPSRRDRFRPLELLGFSGVVALFVGLIVLMSTRQASLTFIFAGISFIVTLMTLAMLSLTSKPTGEERLDMSQQDREQDRQQDRGH
>NZ_CP017146.1|WP_161884943.1|428739_429384_+|hypothetical-protein
MSVLPDDPAQRSAYWPLPIARAVPAAVLAGIITFSADHSATLGLISFGGFALVTGVLLAVLAWRRLGGMAVRPYLLAQGIVSIALGALALALPRGVPSLFLVVTVWAALTGALELYSGLRARRRHVASGDLLTVGAITAAAAIVFVLIPPEFAQQFTGPDGVERKLDSAVVAVGLLGAYAAIIAVFLVIAGLSAKWGTQKAAPAASDAVKGKST
>NZ_CP017146.1|WP_161884952.1|440575_440983_-|phage-holin-family-protein
MRRFLVRLVINAIALWLTTLIVAGVRVVAYEPGDTTASVLTFLMVALVFGIVNSVIGNFVRIVAFPLYILTLGLIALIVNGLLLLLVEWISSLIGFGLEVDGFWWGVLGALVLALISWIIGIIVRPIVGRDELRR
>NZ_CP017146.1|WP_161887304.1|441137_442247_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MSRDRDQPPVQLRPEIVALAAYRQGKPAPDEAFKLSSNENPFEPIDAILEAIAESSINRYPDGSASAVRARIAQRHGVDIESVHVGAGSVAILAQLIQAAAGSGDEVVYAWRSFEAYPGLVTVAGATSVTVPIDESDGSHDLAAMAAAVTGRTRLILVCSPNNPTGAAVSADAFADFMGTVPRNVLVVLDEAYAEFVTDPTAVSGIGLLDDYPNLVVLRTFSKAYGLAGLRFGYAIGPAYVLDAARTAAIPLSVIEPAQRAAIAALDNEEFLLERVARISALRDEVWRALLEQGWSIPHPQGNFVWFATGEHTAAAAEIFLKHGIVVRALGSDGLRVSIGEAESVGKLLAAAEEVVQNLPTAHARTGLD
>NZ_CP017146.1|WP_161887305.1|442342_443440_+|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha
MVQLLSADGVMQSGATAEEYLPYIEKLSDDELRQFHRDMVVIRRFDIEAANLQRQGQLGLWVPSMGQEAAQVGSARAARDHDHIFPAYREHAVAMVRGVDVLGIIGLLRGTTHGGWNPAESKNFHLYTLVIASQTLHATGYAMGIALDGLHATGDPDKDEAVMVYFGDGATSQGDLNEALVFAASYQTPQVFFLQNNHWAISVPVSVQSRVPLVQRASGFGIPGVQVDGNDVLASFAVTAKNLDEARSGAGPRFIEALTYRVGAHTSSDDPTKYRTDAELQSWIARDPITRFETWLRSRGEGDAFFAAVDEEAEDFAADIRTRTYELGIPSTDKMFDHVYSDPHPVIAAQKQWLENYEASMGSDS
>NZ_CP017146.1|WP_161884953.1|443436_444504_+|alpha-ketoacid-dehydrogenase-subunit-beta
MSEHLITNTDAPHHAGSRDGEAPRPARKAAGTAELPLAKAINAGLRKAMGDDSKVLLMGEDIGPLGGVFRVTEGLQAEFGEKRVLDTPLAESGIIGTAIGLAMRGYRPVCEIQFDGFIFPGFDQITSQLAKMTNRHEGQVQMPVVIRVPYGGHIGAVEHHQESPEAYFAHTPGLRLVSPSTPNDAYWMIQEACRSNDPVMFFEPKSRYWHKGPVDLTGSAAPLHTSRVVRTGSEVTLVGHGAMVTVLLQAAELAASEGTSVEVIDLRSLSPIDYSPIIASVRKTGRLVVASEAPGFVSVSSEIAATVTEAAFYSLEAPVLRVSGFDAPFPPAGLETIYLPDADRVLEAVDRAMAY
>NZ_CP017146.1|WP_161884954.1|444523_445894_+|2-oxo-acid-dehydrogenase-subunit-E2
MSSREFNLPDVGEGLTEAEIVAWKVAEGDTVTVNQVLVEIETAKSLVELPSPFAGVVTKLLVEEGTMVDIGTAIISVSDAGAPATPDATPDAAPASAAAPAAAPAPSNDATETIADTAASIAADDDKPGAVLVGYGIKGHVAPRRNRQSAADAPPTRAAARPSSVPAASASAIIAKPPIRKLAKDLGVDLATVTATGLAGEITRDDVVREASQASLFRNIETPQWATDREERIPVKGVRKAIASTMVSSAFSAPHVSLFVDVDATRTMEFVKRLKNSPDFAGVKVSPLLIMAKAMIWAVRRNPTANAQWTDEEIVVKHYVNFGIAAATPRGLIVPNIKEAQDLPLIELARAIEQLTITAREGRTQPSAMAGGTITITNIGVFGMDTGTPILNSDEVAIVALGTIKQKPWVVDGEVRPRFVTTLGASFDHRVVDGDVASRFLADVASIIEEPALLLD
>NZ_CP017146.1|WP_161884955.1|445975_446962_+|zinc-ABC-transporter-solute-binding-protein
MRPKLSTGLLLSSVAASSLVLAGCASPSGSPTTDVDLLQVVASTNVYGDIASRVGGDLVDVTSIITGQAQDPHSYEASARDQLALAKADLVIENGGGYDPFIDTLLAGIATSERVVVTASEVSGLLDGDEDQGDDHATDADADADADADAHAHVEGFNEHVWYSFHAMENLAKALADEFGDFDPANETAYVENYEAFVGDLALLEERAAELRVSVEGNGVAVTEPVPAYLLEEIGLVNLTPDAFSEAFEEGADVPPAVLQETLALFSAGSVSLLAYNEQTTGPETEQVRGAAEEAGVAVVSFSETMPEGADYIGWMTDNLDALADALG
>NZ_CP017146.1|WP_161887306.1|447108_447873_+|ATP-binding-cassette-domain-containing-protein
MLWKGLNLELKAGEFLAVLGPNGTGKTSLLKTILGQQSLTSGTIELLGGPVARGSRNIGYIPQQKLLDDGTPLRARDLVALGINGHQWGLPLSTRALRERVDSILDSVGATAFANVPVATLSGGEQQRVRVGQAIAGNPRILLCDEPLLSLDLNHQRAVSELIDSKRRELNTAVVFVTHDVNPILSMVDRVLYLAGGMFRIGTPDEVMRSEVLSYMYDTPVEVIRSRGRIIVVGAPDGYGAHDHDLHHVGEGHH
>NZ_CP017146.1|WP_161884956.1|447872_448763_+|metal-ABC-transporter-permease
MGDIFDFSNYGELLLLVQNSIYAGALLGVVGGLIGVFVMMRDLPFAVHGISELSFAGAAAALLLGANVVIGSTIGSLLAALLIGVLGVRARERNSIIAVLMPFGLGLGILFLALYEGRSANKFGLLTGQIVSVDNEQLGLLIGISVLVVIGLMIMWRPLTFASVDADVARARGLPVRALSVAFMILLGLAVAVSIQVVGALLVMALLVTPAAAAMRVTSSPLLTPLLSVVFAVVAMVGGILLALGGGLPISPFVTTISFLIYVVCRIVGARMPKARRSGEPSGVVFAGTSAAVLPR
>NZ_CP017146.1|WP_161884957.1|448773_449184_+|transcriptional-repressor
MKRNTWQREAVREALGSNEGFVSAQGLHSSLREAGSSIGLATVYRALADLATEGEADSLQSDQGKSLYRACTPGQHHHHLICRNCGLTVEIEADAVEAWAHTVASDNGFTQASHIVDVFGLCASCSASPAALAHGA
>NZ_CP017146.1|WP_161884958.1|449267_451661_+|phosphoenolpyruvate-synthase
MRDQHVVWFEDISLGDIPQVGGKNASLGEMVGALAASGVQVPPGFATTADSYRAFLVAGDLEPAIRDLLERYRLGDASLRVTGAAIRELFLDSQFPEDIADDIRTAYRTLADRAGIDNPPVAVRSSATAEDLPDASFAGQQETFLNVRGVRDLLDTCRRCYASLFTDRAISYREAKGFDHLEVALSIGIQRMVRSDVGGSGVMFSIDTDTGFPNAIVISAAWGLGETVVQGTVDPDKYLVFTPLLADAGVTPIIEKTVGGKASKMVYGAGGSARIRLVDTTERERRALVLDDSEIVQLARWAAIVAEHYGRPMDMEWAKDGLTGELFLVQARPETVQAGKAADRFTVHRLVESGRVLVTGAAIGESIAVGEACVIRSSADIEKFRDGAILVTEMTDPDWVPIMRRAAGIVTDHGGATSHAAIVSRELGVPAIVGTGTATVDLAEGSTITLSCAEGDEGHVYEGALAFETEEVDLGDVPRTRTRVMVNVASPAAAFQWWRLPADGVGLARMEFIINNLIKVHPMALVHPERVAQKDRELITELSRGFAGPQDYFVQTLARGIAKLAAPYYPNPVIVRLSDFKTNEYAHLIGGGVFERAEENPMLGFRGASRYYDPRYREGFALECRALKRVREHMGFTNVIVMVPFCRTPAEADRVLETMAQNGLVRGENGLKVYMMCEIPSNVILAELFATRFDGFSIGSNDLTQLVLGVDRDSEELAGLFDERDEAVTRSISEAIRKAHEAGIPIGICGQGPSNHPDFAAFLVREGIDSISLNPDSFLRTVHLIADAETATLQAAR

Crispr_ID: NZ_CP017146_2

• CRISPR_ID: NZ_CP017146_2
• CRISPR_location: 544677-544774
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP017146_2

Consensus_repeat	Method
GTAATCGCACCCACGCGGCTGAAC	CRISPRCasFinder

spacers of NZ_CP017146_2

>2.1|544701|50|NZ_CP017146|CRISPRCasFinder
GGCGACCGCACAACCGGTCACTCGCGCGGGTGCTCGTCAGTTGCGTGGTT

CRISPR arrays and Neighbor proteins around NZ_CP017146_2

CRISPR arrays

The CRISPR arrays of NZ_CP017146_2

>merge|NZ_CP017146|2|544677-544774|CRISPRCasFinder
GTAATCGCACCCACGCGGCTGAACGGCGACCGCACAACCGGTCACTCGCGCGGGTGCTCGTCAGTTGCGTGGTTGTAATCGCACCCACGCGGCTGAAC

>NZ_CP017146|2|2|544677-544774|CRISPRCasFinder
GTAATCGCACCCACGCGGCTGAAC	GGCGACCGCACAACCGGTCACTCGCGCGGGTGCTCGTCAGTTGCGTGGTT
GTAATCGCACCCACGCGGCTGAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017146.1|WP_161885055.1|551063_551864_-|TVP38/TMEM64-family-protein	unknown	unknown	gnl|CDD|223475
NZ_CP017146.1|WP_161887312.1|539342_540383_+|polyprenyl-synthetase-family-protein	unknown	unknown	gnl|CDD|173833
NZ_CP017146.1|WP_161885046.1|541257_542859_+|phytoene-desaturase	unknown	unknown	gnl|CDD|274273
NZ_CP017146.1|WP_161885054.1|550435_551071_-|CDP-alcohol-phosphatidyltransferase-family-protein	unknown	unknown	gnl|CDD|223632
NZ_CP017146.1|WP_161885047.1|542863_543217_+|lycopene-cyclase-domain-containing-protein	unknown	unknown	gnl|CDD|274590
NZ_CP017146.1|WP_161885042.1|535855_536764_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161885051.1|546284_547715_-|MFS-transporter	unknown	unknown	gnl|CDD|225179
NZ_CP017146.1|WP_161885041.1|535346_535574_-|low-temperature-requirement-protein-A	unknown	unknown	gnl|CDD|377704
NZ_CP017146.1|WP_161885056.1|553255_554134_+|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|224098
NZ_CP017146.1|WP_161885048.1|543213_543738_+|lycopene-cyclase-domain-containing-protein	unknown	unknown	gnl|CDD|274590
NZ_CP017146.1|WP_161887314.1|552010_553240_+|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|183238
NZ_CP017146.1|WP_161885053.1|548468_549992_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|235787
NZ_CP017146.1|WP_161885045.1|540379_541261_+|squalene/phytoene-synthase-family-protein	unknown	unknown	gnl|CDD|173831
NZ_CP017146.1|WP_161887313.1|545585_546029_-|CDP-alcohol-phosphatidyltransferase-family-protein	unknown	unknown	gnl|CDD|376450
NZ_CP017146.1|WP_161885050.1|544893_545340_-|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
NZ_CP017146.1|WP_161885049.1|543734_544613_+|prenyltransferase	unknown	unknown	gnl|CDD|183861
NZ_CP017146.1|WP_161885052.1|547768_548410_-|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|225136
NZ_CP017146.1|WP_161885057.1|554141_555116_+|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|224098
NZ_CP017146.1|WP_161885043.1|537112_537715_+|dCTP-deaminase	unknown	unknown	gnl|CDD|234753
NZ_CP017146.1|WP_161885044.1|538744_539290_-|isopentenyl-diphosphate-Delta-isomerase	unknown	unknown	gnl|CDD|235156

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP017146.1|WP_161885055.1|551063_551864_-|TVP38/TMEM64-family-protein	gnl|CDD|223475	COG0398, COG0398, Uncharacterized conserved protein [Function unknown].	2.50648e-32
NZ_CP017146.1|WP_161887312.1|539342_540383_+|polyprenyl-synthetase-family-protein	gnl|CDD|173833	cd00685, Trans_IPPS_HT, Trans-Isoprenyl Diphosphate Synthases, head-to-tail. These trans-Isoprenyl Diphosphate Synthases (Trans_IPPS) catalyze head-to-tail (HT) (1'-4) condensation reactions. This CD includes all-trans (E)-isoprenyl diphosphate synthases which synthesize various chain length (C10, C15, C20, C25, C30, C35, C40, C45, and C50) linear isoprenyl diphosphates from precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). They catalyze the successive 1'-4 condensation of the 5-carbon IPP to allylic substrates geranyl-, farnesyl-, or geranylgeranyl-diphosphate. Isoprenoid chain elongation reactions proceed via electrophilic alkylations in which a new carbon-carbon single bond is generated through interaction between a highly reactive electron-deficient allylic carbocation and an electron-rich carbon-carbon double bond. The catalytic site consists of a large central cavity formed by mostly antiparallel alpha helices with two aspartate-rich regions (DDXX(XX)D) located on opposite walls. These residues mediate binding of prenyl phosphates via bridging Mg2+ ions, inducing proposed conformational changes that close the active site to solvent, protecting and stabilizing reactive carbocation intermediates. Farnesyl diphosphate synthases produce the precursors of steroids, cholesterol, sesquiterpenes, farnsylated proteins, heme, and vitamin K12; and geranylgeranyl diphosphate and longer chain synthases produce the precursors of carotenoids, retinoids, diterpenes, geranylgeranylated chlorophylls, ubiquinone, and archaeal ether linked lipids. Isoprenyl diphosphate synthases are widely distributed among archaea, bacteria, and eukareya.	6.30688e-57
NZ_CP017146.1|WP_161885046.1|541257_542859_+|phytoene-desaturase	gnl|CDD|274273	TIGR02734, Phytoene_desaturase_lycopene-forming, phytoene desaturase. Phytoene is converted to lycopene by desaturation at four (two symmetrical pairs of) sites. This is achieved by two enzymes (crtP and crtQ) in cyanobacteria (Gloeobacter being an exception) and plants, but by a single enzyme in most other bacteria and in fungi. This single enzyme is called the bacterial-type phytoene desaturase, or CrtI. Most members of this family, part of the larger pfam01593, which also contains amino oxidases, are CrtI itself; it is likely that all members act on either phytoene or on related compounds such as dehydrosqualene, for carotenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_CP017146.1|WP_161885054.1|550435_551071_-|CDP-alcohol-phosphatidyltransferase-family-protein	gnl|CDD|223632	COG0558, PgsA, Phosphatidylglycerophosphate synthase [Lipid metabolism].	1.54763e-09
NZ_CP017146.1|WP_161885047.1|542863_543217_+|lycopene-cyclase-domain-containing-protein	gnl|CDD|274590	TIGR03462, Bifunctional_lycopene_cyclase/phytoene_synthase, lycopene cyclase domain. This domain is often repeated twice within the same polypeptide, as is observed in Archaea, Thermus, Sphingobacteria and Fungi. In the fungal sequences, this tandem domain pair is observed as the N-terminal half of a bifunctional protein, where it has been characterized as a lycopene beta-cyclase and the C-terminal half is a phytoene synthetase. In Myxococcus and Actinobacterial genomes this domain appears as a single polypeptide, tandemly repeated and usually in a genomic context consistent with a role in carotenoid biosynthesis. It is unclear whether any of the sequences in this family truly encode lycopene epsilon cyclases. However a number are annotated as such. The domain is generally hydrophobic with a number of predicted membrane spanning segments and contains a distinctive motif (hPhEEhhhhhh). In certain sequences one of either the proline or glutamates may vary, but always one of the tandem pair appear to match this canonical sequence exactly.	5.23828e-07
NZ_CP017146.1|WP_161885045.1|540379_541261_+|squalene/phytoene-synthase-family-protein	gnl|CDD|173831	cd00683, Trans_IPPS_HH, Trans-Isoprenyl Diphosphate Synthases, head-to-head. These trans-Isoprenyl Diphosphate Synthases (Trans_IPPS) catalyze a head-to-head (HH) (1'-1) condensation reaction. This CD includes squalene and phytoene synthases which catalyze the 1'-1 condensation of two 15-carbon (farnesyl) and 20-carbon (geranylgeranyl) isoprenyl diphosphates, respectively. The catalytic site consists of a large central cavity formed by mostly antiparallel alpha helices with two aspartate-rich regions (DXXXD) located on opposite walls. These residues mediate binding of prenyl phosphates. A two-step reaction has been proposed for squalene synthase (farnesyl-diphosphate farnesyltransferase) in which, two molecules of FPP react to form a stable cyclopropylcarbinyl diphosphate intermediate, and then the intermediate undergoes heterolysis, isomerization, and reduction with NADPH to form squalene, a precursor of cholestrol. The carotenoid biosynthesis enzyme, phytoene synthase (CrtB), catalyzes the condensation reaction of two molecules of geranylgeranyl diphosphate to produce phytoene, a precursor of beta-carotene. These enzymes produce the triterpene and tetraterpene precursors for many diverse sterol and carotenoid end products and are widely distributed among eukareya, bacteria, and archaea.	2.39259e-51
NZ_CP017146.1|WP_161885041.1|535346_535574_-|low-temperature-requirement-protein-A	gnl|CDD|377704	pfam06772, LtrA, Bacterial low temperature requirement A protein (LtrA). This family consists of several bacteria specific low temperature requirement A (LtrA) protein sequences which have been found to be essential for growth at low temperatures in Listeria monocytogenes.	2.67687e-09
NZ_CP017146.1|WP_161885056.1|553255_554134_+|ABC-transporter-permease-subunit	gnl|CDD|224098	COG1177, PotC, ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism].	2.16286e-16
NZ_CP017146.1|WP_161885048.1|543213_543738_+|lycopene-cyclase-domain-containing-protein	gnl|CDD|274590	TIGR03462, Bifunctional_lycopene_cyclase/phytoene_synthase, lycopene cyclase domain. This domain is often repeated twice within the same polypeptide, as is observed in Archaea, Thermus, Sphingobacteria and Fungi. In the fungal sequences, this tandem domain pair is observed as the N-terminal half of a bifunctional protein, where it has been characterized as a lycopene beta-cyclase and the C-terminal half is a phytoene synthetase. In Myxococcus and Actinobacterial genomes this domain appears as a single polypeptide, tandemly repeated and usually in a genomic context consistent with a role in carotenoid biosynthesis. It is unclear whether any of the sequences in this family truly encode lycopene epsilon cyclases. However a number are annotated as such. The domain is generally hydrophobic with a number of predicted membrane spanning segments and contains a distinctive motif (hPhEEhhhhhh). In certain sequences one of either the proline or glutamates may vary, but always one of the tandem pair appear to match this canonical sequence exactly.	5.8672e-09
NZ_CP017146.1|WP_161887314.1|552010_553240_+|ABC-transporter-substrate-binding-protein	gnl|CDD|183238	PRK11622, PRK11622, ABC transporter substrate-binding protein.	1.54898e-157
NZ_CP017146.1|WP_161885053.1|548468_549992_+|FAD-dependent-oxidoreductase	gnl|CDD|235787	PRK06370, PRK06370, FAD-containing oxidoreductase.	2.29037e-130
NZ_CP017146.1|WP_161885051.1|546284_547715_-|MFS-transporter	gnl|CDD|225179	COG2270, COG2270, Permeases of the major facilitator superfamily [General function prediction only].	6.09679e-102
NZ_CP017146.1|WP_161887313.1|545585_546029_-|CDP-alcohol-phosphatidyltransferase-family-protein	gnl|CDD|376450	pfam01066, CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.	2.53423e-07
NZ_CP017146.1|WP_161885050.1|544893_545340_-|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	6.4018e-07
NZ_CP017146.1|WP_161885049.1|543734_544613_+|prenyltransferase	gnl|CDD|183861	PRK13105, ubiA, prenyltransferase; Reviewed.	1.13187e-148
NZ_CP017146.1|WP_161885052.1|547768_548410_-|methyltransferase-domain-containing-protein	gnl|CDD|225136	COG2226, UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism].	1.15386e-19
NZ_CP017146.1|WP_161885057.1|554141_555116_+|ABC-transporter-permease-subunit	gnl|CDD|224098	COG1177, PotC, ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism].	3.31408e-32
NZ_CP017146.1|WP_161885043.1|537112_537715_+|dCTP-deaminase	gnl|CDD|234753	PRK00416, dcd, deoxycytidine triphosphate deaminase; Reviewed.	2.84602e-96
NZ_CP017146.1|WP_161885044.1|538744_539290_-|isopentenyl-diphosphate-Delta-isomerase	gnl|CDD|235156	PRK03759, PRK03759, isopentenyl-diphosphate Delta-isomerase.	3.28857e-98

Protein sequences

>NZ_CP017146.1|WP_161885049.1|543734_544613_+|prenyltransferase
MTALRTTTVLKSLFVSSRPLSWVNTAFPFAAAYFVTTREVDLLLVLGTIYFLIPYNLAMYGINDVFDYESDLHNPRKGGVEGALLDPRVHRATLVAAVATNIPFLVYLFAVGSPVSALVLAVSVFAVIAYSAPRLRFKERPFLDSLTSSTHFVSPAVFGLVIAGATFSPQLLAILIAFFLWGIASHAFGAVQDVVADREGGIASTATVIGARATVRLAFVAYVLAGILLLTLGLPGAIASVLAVPYALSVLPFWSIADADAGSANRGWKRFLWFNFVSGFVVTMLLIAWVSL
>NZ_CP017146.1|WP_161885048.1|543213_543738_+|lycopene-cyclase-domain-containing-protein
MTYWALNVFFLGAVAVVAVLAVLRAWRSGSRGTGARGTGGGGAGGAVAGRIVAGPAVAGPAVAGRIVAGPAVAGPAVSWPAVGIAAALLLVMTAVFDNIMIGVGLVGYDETLISGAFIGIAPLEDFAYTVAAVVLLPSLWALLPVSSGSASAGTDSPSASPSASPSASPSGGDA
>NZ_CP017146.1|WP_161885047.1|542863_543217_+|lycopene-cyclase-domain-containing-protein
MGILYLAALTIALTGMVVLDRRFGLFFWADARRAAVVLVAGVAFFLVWDLLGIGLGIFFRGETSFMTGLVIAPELPIEEVFFLALLCYLTMNAYAAAGRMLARMPARMPADRRGAAS
>NZ_CP017146.1|WP_161885046.1|541257_542859_+|phytoene-desaturase
MSSIIVIGGGISGLASAALLAREGHQVTLLEGRDEVGGRAGSWDHEGFRFDLGPSWYLMPEVFDHFYKLLGTSAAEQLDLVTLDPGYRVLFEGQQSIDITSDREKNLEIFEAIEPGSRVRMEKYLASAYDTYEIAKKRFLYTSFADLRPLLRRDVLSRLGKLARLLLQPLSTLAAKTVRDDRLRQILGFPAVFLGSSPFITPSMYHLMSHLDLADGVLYPMGGLIKLIDSIEELTREEGVTIITGARVTRILVDTSQPGKPTAAGVEYTDAAGAPQALEADIVVSAADLHHTETTLLPRELQTYPQEYWDKRTPGPGALLLYLGVEGRLPELEHHNLLFTKDWKKGFDAIFGDTPSIPNPASLYVCKPSGVDPTVAPPGYENLFVLVPIPSDPTIGHGEIDGDGDPRIEAAADHVIEQIASWAGIPDLADRIVVRRTMGPGDFADDLNSWRGTLLGPAHTLKQSALFRAGNVSKKVDGLYFVGGSTIPGIGLPMCLISSEVLLKRLRGDVSTEPLPEPLVSSLVAPAPASDLR
>NZ_CP017146.1|WP_161885045.1|540379_541261_+|squalene/phytoene-synthase-family-protein
MTRDSLYDRVAEETAGIVIRRYSTSFGLASRLLGPAVRQHVENIYALVRIADEIVDGAADAAGADRSTVARILDELERDTDEAMLTGYSANLVVHAFALTARDTGFGTELTAPFFASMRADLSATEHDQASFETYVYGSAEVVGLMCLKTFLVGVNVTADDEATMVTGARRLGAAFQKVNFLRDLAADFEQLGRSYFPGVDVASFTEADKVRLLDDIDADLAVSASVIPMLPRSSRRAVALAQGLFAELSARLRATPADRLVRSRVRVPNPVKLRIAATAASGRVPRIERVAR
>NZ_CP017146.1|WP_161887312.1|539342_540383_+|polyprenyl-synthetase-family-protein
MERQAQVDAVLDRFFSLSKNRAAKFGAEYVGLWKKLESSASGGKRFRPRMVMAAYEGLGGLDADAAAYVGAAFELLHTALIVHDDVIDRDFSRRGIPNVSGSYRDIATTAGIPIPTAEHRGMSAAVIAGDLALFNSYRLIDLSGVDAGIRGLLLEILDDALFASAAGELIDVDFSVAATMPSVEEVLRMERLKTAVYSFEAPLQAGAVLAGAPQSVVDRLGRYGCEIGIAYQIVDDLLGVFGLEEQTGKSTIGDLREGKRTVLIAHATTTEHWAEIRPLVGKADLSLAEATRIRSALEASGSREFTESLAREYVARALITINDPEIPAPMLAELESVARGVLSRVK
>NZ_CP017146.1|WP_161885044.1|538744_539290_-|isopentenyl-diphosphate-Delta-isomerase
MTATTEYVVLLGDDGTPLGTADKATVHTTDTPLHLAFSCHVFDADGRVLLTRRALSKRTWPGVWTNSFCGHPAPGEAPEDAVARRAQHELGITISAVSPMLPDFRYRAVDASGIVENEICPVFSAVTTDTVNPSPDEVTEWAWLRPDELRAAVEAAPFAFSPWLVMQLQEWPKPDAARDLP
>NZ_CP017146.1|WP_161885043.1|537112_537715_+|dCTP-deaminase
MLLSDRDIKAELDSGRVSLEPYAPEMIQPSSIDVRLDRYFRLFDNHKYPFIDPAEDQPDLTRLVEAKPDEPFILHPGEFVLGSTFEQVTLPDDLAARLEGKSSLGRLGLLTHSTAGFVDPGFSGHVTLELSNVATLPIKLWPGMKIGQLCFIRLSSPAEHPYGSAAYSSRYQGQRGPTASRSFQNFHRSNTFDRDESRLD
>NZ_CP017146.1|WP_161885042.1|535855_536764_-|hypothetical-protein
MTTLLDPLILVQRDRIDPRSLARDVDRGARVRIKRGAYYDAAVWQALTDQQRHRIRIEAFAFSHHGLVFSHYSAAVLHGIPFIGSVPDLVHVVADRANGGRSEPGLLRHCLGITPAELTEAGALRVETPLRTVVGLSRLQPFRLAVAPADHLLHTASIEALRAGLELANFGRGFAKARRVIEFANGLAANPGESLSRAVIHELGFPAPMLQVEHLTALGHRYLTDFEWPGWQLAGEFDGKGKYLKPEYLGRMTPGEAVVKEKRREDELRAEGLNFARWDWADALSGHLLRDILLRAGLPRRS
>NZ_CP017146.1|WP_161885041.1|535346_535574_-|low-temperature-requirement-protein-A
MRYWMPVIKATPIESWQVLGGNMAEPAGLFMILALGESIIVTGTLFSRNEIPPSSVLALLAAFDPLLVALLQPRR
>NZ_CP017146.1|WP_161885050.1|544893_545340_-|MarR-family-transcriptional-regulator
MTDQRPIGYWLKLVDRLIDEHFDGTLDEHGVTRRQWQLLNLLGRGPATREELNDALSPFLGTDGTTAGEIDELVESDWVAASPSGFALTPRGETAFERISEVVARIRADMSQGLSPEEYNVTIRSLERMSRNLGWTEPGERRMEPTAG
>NZ_CP017146.1|WP_161887313.1|545585_546029_-|CDP-alcohol-phosphatidyltransferase-family-protein
MAVTHLGMLGDRRSIGIPNALTLIRGTLPALEDRLGRSLPVISLATDFADGKIARATGTVTPFGTQADFLADTAFWTWFIVRHEPSRAVKALTFAAWAAPVVAIAAASITTGRMLDVPRSAWLRPAAAMEVVIGIRAILRLFPRRRH
>NZ_CP017146.1|WP_161885051.1|546284_547715_-|MFS-transporter
MSDPSSADGTAPEPPFPSDDDAVNTVGQGLMDDTPVPKGRVRAWALWDWGSASFNAVVTTFVFSTYLASSLFFDPEILASRGEQAAQAASAQVVAGALTIAGVLIALLAPILGQRSDGSGRRKLWLAINTGLVVLAMCAMFFVAPVPSYIYLGAALLAAGNIFFEFASVNYNAMLVQVSTPSTVGRVSGFGWGMGYVGGIVLLVLLLVVFIGGVAGIGSGGLLGLPSGSDGGSLDIRIAIVVAALWFAVFALPVLIAVPEIPARVRENRVSFFGSYVLLFRTIRLLAKKSPQVLLFLLASAVFRDGLAGVFTLGAIIAAQVFGFSFAEVLIFGVAANVVAGIGTFIGGYLDDRVGAKAIIIASLGGLVIAGSAVLFVGDAKSGFWVAGLFLTLFVGPVQSSSRSFLARITPPGREGEIFGLYATTGRAVSFLAPGLFGLFVLMTGDTRFGIIGIVIVLLAGLLLMLPVKPRPARID
>NZ_CP017146.1|WP_161885052.1|547768_548410_-|methyltransferase-domain-containing-protein
MLKRYTAGARLYDVLSGERLVYRVGRVAGIDALQPGRGDIVLDLGCGTGLNLPLLLDRVGAEGHVIGLDRSPSMLAVARDRVRRNGWANVSLLEADVLLLDPAEITSIALREGGRPRVDAAFSSYAMSVFDDWMPAWELLRSVARPGARAGIVDMALPTGAAAVFAPLARLACAAGGADITARPWRAPEREAANAEHTVLRGGHIHVVTGTLP
>NZ_CP017146.1|WP_161885053.1|548468_549992_+|FAD-dependent-oxidoreductase
MEERAEWELVVIGGGSAGLVASRTAASFGADTLLIEGDRLGGDCLWTGCVPSKSLIAAASALTIARNSPHFGVEADAVELDFAAAMRHVHSAMHTIAPVDSPEVLALAGVEVLRGHARFTGPRSLNVEGREIGFGQVIIATGGSPAVPKIDGIGSVEVLTSATVWDLTALPERLVVLGGGAVGCEIAQAMARFGSVVTIVHRGDRLLVKEAPRASAIVQAALEADGVTVLTGRQAASISGDGDGDGDRDRRGLGGGDGDRDRRGPGGGRSGAVTLDDGTVVPFDAILAAIGRAPNTGSLDADRAGVELDEAGNVVVNARLRTANPRIWAAGDVTPLPKFTHTAGMNGSIAASNAVLGLFRTIDSTAVPRVTFTHPEVGSVGIVQADAAAQGLIARTIEHEHVDRAIAEGAIGGYTQLLVDKRGKIRGATIVGPRAGESLGEVSLAISRGLTTSDIAGTTHAYPTFSDAVWNAAVADVRARLNQGATKVATTALRRLRRWRLRRWRLR
>NZ_CP017146.1|WP_161885054.1|550435_551071_-|CDP-alcohol-phosphatidyltransferase-family-protein
MLDSHVRRLIDKPLTSVASAIDRPWISPDRLTIAGLVLGLASALAAALTLWWLALLLWLASRILDGLDGSLARLRRSREDAGAGGSSEAGGFLDIVSDFVVYGATVFGVAVGASVAFDAPWWPFALVLLTYYVNGSAFLAFSSTAERTGRRIDDGRSLSFLGRIAEGTETIIVHSLWLVVPFLAWQIAVVWGVFVAVSAVQRIVVGYRSLR
>NZ_CP017146.1|WP_161885055.1|551063_551864_-|TVP38/TMEM64-family-protein
MNARVDTSARRRALLKLAAFLAFVAVAVSVGVALELPGLDEIRTAAEAAGWPGAIGFALVYGLATLAPVPKSVLSIAAGIIWGFALGALLVYLGALLGAALAFAIGRGLGRDAVERFTGARVERIDEILRRRGLASIIGARLIPVLPFTVINYTAGLTSVRRRDYAIGTMLGIIPGTLAFVAVGGFGFEPGPGLYVAVGTLGALSIAGAIVGIRMRRGGASVPPQTRTQTPSPAPTQPQVPAPAQVQAQAPAQAPAQAPVPGEPDA
>NZ_CP017146.1|WP_161887314.1|552010_553240_+|ABC-transporter-substrate-binding-protein
MTRRAKVAAAVGLLALTGCSAPNSEAATHDFASWDEVVSAAEGQTVQLWMYGGDQQGNAYIDDVLAPAVAEQGVTLERVPVTDTADALNRVLSELQAGRTADGTVDLIWVNGANFSTGKEAGAWLCDWTSLLPNMDKTAVDDPLLSDDFGTPVDGCEVPWHKAQFTIAYNSDIIENPPTSLAGVLDWARAHPGRFTYPAPPDFTGSVFTRQVLYSVSGGYENVPLTYDQESFDELSPALYEKLVDLAPSLWRAGDTYPASSDELNQLYADGQVDMTMTYGPATLTDLVAGGVYPAGTRILTLDEGTVGNASFLGLPSNAESRAGAMVVANTALSVEQQVAKADPEAWGQFTVLDYDSLASAEQALFDALPKSLVVPSYDILSTNANPELSAAWVPPLDEGWRTRVLGAR
>NZ_CP017146.1|WP_161885056.1|553255_554134_+|ABC-transporter-permease-subunit
MSLAPLRGRTAAAGRPGLRGTLLILPAVVPALFVLGGGIGAAVAQSLGLLPLIGPVRLSLDAYTAQSGALPVSIAVSLGIATASTAIAAVVGFAAALVIVSGRWGGRIVAAISAATVTMPHLIGAAAIGLLLADSGLLPRLLGIDADAWPRLVGGPWWVAVVAEYAWKESAFVALVVAGTLATRVASFDETAALLGAGRLARLRFVMIPLCLPALVVSSTIVFVYTLGSYEVAWLLGRSYPEPLPVMALRLFGSITLTARPEAAAVAVVTTAISLAVVALAFLALRRTALWR
>NZ_CP017146.1|WP_161885057.1|554141_555116_+|ABC-transporter-permease-subunit
MSLQARSLTADPQRADAGRLRLPGDPGSRLTDSRGAGRVGRVLSATLLAAWFLVPLVPLALWAFADRWSFPEVLPTVWGIDGLESAIAQGAVPAFWRSLALGLVVAAIATPLGAAAARALTMGVVRWPRAVGLVLLAPIALPPFAAVMGLNVVLLRAYVPPLVGLVLVLVVIALPYTTFAMRVAYAAHDIRFEEEARTLGASPWTVLWRIHIPLVAPALARAAFLAFLVGWSDYIVTVIIGGGAVVTLPLVIASSAAGIGNDSAVAILSLTAILPPLMLLLLLGLAGRRGAGRRGARPRRRRPAPDPIGPRTARSRLHETGATR

Crispr_ID: NZ_CP017146_3

• CRISPR_ID: NZ_CP017146_3
• CRISPR_location: 665085-665278
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP017146_3

Consensus_repeat	Method
TACTACCCGCGCAGGCGCGCAGTGCCCGCGCG	PILER-CR

spacers of NZ_CP017146_3

>3.1|665117|65|NZ_CP017146|PILER-CR
AAAGGCCGTGTCTGCGGCTCCGGCTGGTGTTCGCGGGTTGGGCGCGCCCGCGCGGGTGGTGGGCC
>3.2|665214|40|NZ_CP017146|PILER-CR
GGCCGGTTTCTTCGGTGCTCAGGCTCCGTGGCGCCTGTTC

CRISPR arrays and Neighbor proteins around NZ_CP017146_3

CRISPR arrays

The CRISPR arrays of NZ_CP017146_3

>merge|NZ_CP017146|3|665085-665278|PILER-CR
TTCTGCCCGCGCGAACGCGCAGCGCCCGCGCGAAAGGCCGTGTCTGCGGCTCCGGCTGGTGTTCGCGGGTTGGGCGCGCCCGCGCGGGTGGTGGGCCACACGCGTTGGCGCGCAGTGCCCGCGCGGGCCGGTTTCTTCGGTGCTCAGGCTCCGTGGCGCCTGTTCTACTACCCGCGCAGGCGCGCAGTGCCCGC

>NZ_CP017146|3|1|665085-665278|PILER-CR
TTCTGCCCGCGCGAACGCGCAGCGCCCGCGCG	AAAGGCCGTGTCTGCGGCTCCGGCTGGTGTTCGCGGGTTGGGCGCGCCCGCGCGGGTGGTGGGCC
ACACGCGTTGGCGCGCAGTGCCCGCGCGGGCC	GGTTTCTTCGGTGCTCAGGCTCCGTGGCGCCTGTTCTACT
ACCCGCGCAGGCGCGCAGTGCCCGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017146.1|WP_161885143.1|672690_672909_+|hypothetical-protein	unknown	unknown	gnl|CDD|129992
NZ_CP017146.1|WP_161885146.1|674018_674687_-|cyclase-family-protein	unknown	unknown	gnl|CDD|224790
NZ_CP017146.1|WP_161885142.1|669115_672532_+|MMPL-family-transporter	unknown	unknown	gnl|CDD|223911
NZ_CP017146.1|WP_161885141.1|666184_668503_+|copper-translocating-P-type-ATPase	unknown	unknown	gnl|CDD|319783
NZ_CP017146.1|WP_161885131.1|652096_653206_+|LacI-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NZ_CP017146.1|WP_161885140.1|665957_666188_+|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl|CDD|225328
NZ_CP017146.1|WP_161885132.1|653202_654441_+|extracellular-solute-binding-protein	unknown	unknown	gnl|CDD|270451
NZ_CP017146.1|WP_161885133.1|654507_655641_+|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096
NZ_CP017146.1|WP_161885148.1|676263_677379_+|agmatinase	unknown	unknown	gnl|CDD|212538
NZ_CP017146.1|WP_161885147.1|674753_676334_+|cytosine-permease	unknown	unknown	gnl|CDD|224374
NZ_CP017146.1|WP_161885136.1|659085_660783_+|AMP-binding-protein	unknown	unknown	gnl|CDD|235531
NZ_CP017146.1|WP_161885135.1|657604_659017_+|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl|CDD|224089
NZ_CP017146.1|WP_161885137.1|660876_661407_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161887323.1|662490_664896_+|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl|CDD|319850
NZ_CP017146.1|WP_161885145.1|673444_673993_-|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|380339
NZ_CP017146.1|WP_161885139.1|665537_665822_+|metal-sensitive-transcriptional-regulator	unknown	unknown	gnl|CDD|376835
NZ_CP017146.1|WP_161885134.1|655637_656543_+|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472
NZ_CP017146.1|WP_161885130.1|649756_651868_-|amylo-alpha-1,6-glucosidase	unknown	unknown	gnl|CDD|225942
NZ_CP017146.1|WP_161885138.1|661508_662153_+|DUF305-domain-containing-protein	unknown	unknown	gnl|CDD|367619
NZ_CP017146.1|WP_161885144.1|672933_673269_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP017146.1|WP_161885143.1|672690_672909_+|hypothetical-protein	gnl|CDD|129992	TIGR00914, Nickel-cobalt-cadmium_resistance_protein_NccA, heavy metal efflux pump, CzcA family. This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds].	9.33682e-08
NZ_CP017146.1|WP_161885146.1|674018_674687_-|cyclase-family-protein	gnl|CDD|224790	COG1878, COG1878, Kynurenine formamidase [Amino acid transport and metabolism].	3.08559e-55
NZ_CP017146.1|WP_161885142.1|669115_672532_+|MMPL-family-transporter	gnl|CDD|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	4.34045e-128
NZ_CP017146.1|WP_161885141.1|666184_668503_+|copper-translocating-P-type-ATPase	gnl|CDD|319783	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B. The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP017146.1|WP_161885131.1|652096_653206_+|LacI-family-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	4.99327e-70
NZ_CP017146.1|WP_161885140.1|665957_666188_+|heavy-metal-associated-domain-containing-protein	gnl|CDD|225328	COG2608, CopZ, Copper chaperone [Inorganic ion transport and metabolism].	2.95836e-12
NZ_CP017146.1|WP_161885132.1|653202_654441_+|extracellular-solute-binding-protein	gnl|CDD|270451	cd14748, PBP2_UgpB, The periplasmic-binding component of ABC transport system specific for sn-glycerol-3-phosphate; possesses type 2 periplasmic binding fold. This group includes the periplasmic component of an ABC transport system specific for sn-glycerol-3-phosphate (G3P) and closely related proteins from archaea and bacteria. Under phophate starvation conditions, Escherichia coli can utilize G3P as phosphate source when exclusively imported by an ATP-binding cassette (ABC) transporter composed of the periplasmic binding protein, UgpB, the transmembrane subunits, UgpA and UgpE, and a homodimer of the nucleotide binding subunit, UgpC. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.44531e-51
NZ_CP017146.1|WP_161885133.1|654507_655641_+|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.73928e-66
NZ_CP017146.1|WP_161885148.1|676263_677379_+|agmatinase	gnl|CDD|212538	cd11592, Agmatinase_PAH, Agmatinase-like family includes proclavaminic acid amidinohydrolase. This agmatinase subfamily contains bacterial and fungal/metazoan enzymes, including proclavaminic acid amidinohydrolase (PAH, EC 3.5.3.22) and Pseudomonas aeruginosa guanidinobutyrase (GbuA) and guanidinopropionase (GpuA). PAH hydrolyzes amidinoproclavaminate to yield proclavaminate and urea in clavulanic acid biosynthesis. Clavulanic acid is an effective inhibitor of beta-lactamases and is used in combination with amoxicillin to prevent the beta-lactam rings of the antibiotic from hydrolysis and, thus keeping the antibiotic biologically active. GbuA hydrolyzes 4-guanidinobutyrate (4-GB) into 4-aminobutyrate and urea while GpuA hydrolyzes 3-guanidinopropionate (3-GP) into beta-alanine and urea. Mutation studies show that significant variations in two active site loops in these two enzymes may be important for substrate specificity. This subfamily belongs to the ureohydrolase superfamily, which includes arginase, agmatinase, proclavaminate amidinohydrolase, and formiminoglutamase.	1.22241e-165
NZ_CP017146.1|WP_161885147.1|674753_676334_+|cytosine-permease	gnl|CDD|224374	COG1457, CodB, Purine-cytosine permease and related proteins [Nucleotide transport and metabolism].	1.05981e-58
NZ_CP017146.1|WP_161885136.1|659085_660783_+|AMP-binding-protein	gnl|CDD|235531	PRK05605, PRK05605, long-chain-fatty-acid--CoA ligase; Validated.	0
NZ_CP017146.1|WP_161885135.1|657604_659017_+|PLP-dependent-aminotransferase-family-protein	gnl|CDD|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	6.11997e-90
NZ_CP017146.1|WP_161887323.1|662490_664896_+|heavy-metal-translocating-P-type-ATPase	gnl|CDD|319850	cd07552, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase. Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	1.77982e-176
NZ_CP017146.1|WP_161885145.1|673444_673993_-|cupin-domain-containing-protein	gnl|CDD|380339	cd02209, cupin_XRE_C, XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain. This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	3.25345e-15
NZ_CP017146.1|WP_161885139.1|665537_665822_+|metal-sensitive-transcriptional-regulator	gnl|CDD|376835	pfam02583, Trns_repr_metal, Metal-sensitive transcriptional repressor. This is a family of metal-sensitive repressors, involved in resistance to metal ions. Members of this family bind copper, nickel or cobalt ions via conserved cysteine and histidine residues. In the absence of metal ions, these proteins bind to promoter regions and repress transcription. When bound to metal ions they are unable to bind DNA, leading to transcriptional derepression.	1.36234e-31
NZ_CP017146.1|WP_161885134.1|655637_656543_+|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.44336e-73
NZ_CP017146.1|WP_161885130.1|649756_651868_-|amylo-alpha-1,6-glucosidase	gnl|CDD|225942	COG3408, GDB1, Glycogen debranching enzyme [Carbohydrate transport and metabolism].	7.12561e-69
NZ_CP017146.1|WP_161885138.1|661508_662153_+|DUF305-domain-containing-protein	gnl|CDD|367619	pfam03713, DUF305, Domain of unknown function (DUF305). Domain found in small family of bacterial secreted proteins with no known function. Also found in Paramecium bursaria chlorella virus 1. This domain is short and found in one or two copies. The domain has a conserved HH motif that may be functionally important. This domain belongs to the ferritin superfamily. It contains two sequence similar repeats each of which is composed of two alpha helices.	4.31128e-40

Protein sequences

>NZ_CP017146.1|WP_161887323.1|662490_664896_+|heavy-metal-translocating-P-type-ATPase
MMPAGEGPHANVDAPAHGDHGASVGHAGHGDHAAQFRSKFWWSLVLGVPVVFFSPMFAGLLGYDIPDFAGSTWIAPVLGTVLFLYGGWPFLTGGWSELTSRRPGMMLLISLAITVAFVASWATTLQIGGFDLDFWWELALLIVIMLLGHWLEMRALGAASGALDALAALLPDSTDKVTDAGVVEVAISELAPGDVVLVRPGARVPADGRVVEGEADVDESMITGESRAVHRGIGDTVVAGTVATDNTLRVEVNAVGDDTALAGIQRLVAEAQQSSSRAQALADRAAGFLFYFALGAAVITFAAWMVLGSPDDAVTRTVTVLVIACPHALGLAIPLVIAISTERAAKAGVLVKDRLALERMRTVDVVLFDKTGTLTKGEPAVTATAVVQGVTERELISIAAAVESDSEHPLARAIVRAAEVAPADAAPAGAAPAGAAPAGAAPAGAAPAGAAPAGAVPADASPADAGVRADAVSAGAGVQADASSAGAGVRVDAVPADAGVQADAAVGRPGPDGTDPGAAVASTAGAARGDASAPASARPVATEFRSMTGRGVQATVDGRTVAVGGPALLTELGLDSPAEMAARVEEFVAAGASVLHVVRDGSVIGAIALEDEVRAESREAIEALHRRGVRVAMITGDAQQVADRVARELDIDEVFAEVLPKDKDAKVAELQARKLKVAMVGDGVNDAPALARAEVGIAIGAGADVAIESAGVVLAGNDPRAVLSVIDLSRASYRKMWQNLAWATGYNIISVPLAAGVLAFAGFVLSPAAGAVLMSVSTVVVALNAQLLRRLDLNPERIVKE
>NZ_CP017146.1|WP_161885138.1|661508_662153_+|DUF305-domain-containing-protein
MTSTRTSTRTRTVLAASAALVAALTLASCAPTEPASVSEPAASAPETELNAAELAEFNEADIMFAQMMIPHHRQAVAMSDTLLAKTGISAETVALAEEIKAAQEPEIAQLNGLLVAWGFDEMTADDDMAGMDHSSGMMTDDDMAALDDATGSEAERLYLEQMIEHHEGAIIMASPQIIDGENADAVALAEAIESAQQKEISEMKKLLAALPAAG
>NZ_CP017146.1|WP_161885137.1|660876_661407_+|hypothetical-protein
MKAALRPALPLLIGIALAAVLALVAMHSLAFGTSAAIVGSHHSVGYATEAAYDTDHQADLAVPDHDTATADAHDHDHGAATIDAHDHGTQTVDAHAHDTATADAHDHGASAVCASSDGAECCSWVANASGAPTITLHAFPGTVVPALAESTPVASLFATEAAERPPSRALLSVIRV
>NZ_CP017146.1|WP_161885136.1|659085_660783_+|AMP-binding-protein
MNNLDRMPWLSAYADGVPDEIEPINQTLVDMIDEAVSNYRRDVALEFFGAETTYNELGDKIALAAEGLRRLGVKAGDRVAIVLPNCPQHVVAFYAVLRLGAIVVEHNPLYTARELRHQFEDHGARIAIVWDKVYDTVAGFPKDIRLERIVSVDLTSALPFGKRFALRLPIPKARTARAAMTATPSGRNVFTWDRLVSGRRLSKRHPAPRPSDTALLQYTSGTSGTPKGAILTHANLRANAAQGEAWVPGLNPGKETFYAVLPLFHAYGLTLCLTFAMSIGARLVLFPRFDVDLVLAAARTSPPTFLPAVPPIYDQLAAAAESRNVDLSSIRFSISGAMSLPLETVRRWEAVTGGLLVEGYGMTESSPVALGNPMGPSRRPGTVGVPFPSTEIRVVDPADPTIDRPNGEPGELLIRGPQVFHGYWQNPEDTAHTLMLDGWLRTGDIVTVAPDGFVTVVDRVKELIITGGFNVSPSEVEAALLAHPDVTAAAVVGLPHQSGGEEVSAAVVLRAGATFDSAALRNFCRESLAGYKVPKRVVVLDELPRSLIGKVMRREVRDALLAGRG
>NZ_CP017146.1|WP_161885135.1|657604_659017_+|PLP-dependent-aminotransferase-family-protein
MSSISARILDLLLQDWRSSAPAYTALADRIRLLVLDGRIPVGARLPAERDLAQRLGVSRTTVSASYAGLREVGYLSSVRGSGSIARLPGRAPVPLHEPSAGFLDFSKAALPASPLLADAAVRAAQALPAYLADTGFDPIGLPRLRQAVADRYAARGLPTDAEQVMITIGAQHAIALLARVLLDRGDSALVESPSYPHAYDALRGAGARLVPVGVSSDGGWDEDALEQGLRRTSPALAYVMPDFHNPTGRVMSAELRERMLGLAALQGTTIIADETMAELGIDEPETMPPLASYGPAVSIGSLGKTVWGGVRIGWIRAEPQLIQKLVRARSAGDLGTPILEQLIAIELLGRYDDVLAGRREQLRLGRAYLERAVGEALPQWTVPHVNGGLTTWVNLGRPASSQLTLAARNEGLVLASGPRFGIDGAFERFLRLPFSYTPDETDRAVASLARAWGALSRHPLPEQNYLAAVV
>NZ_CP017146.1|WP_161885134.1|655637_656543_+|carbohydrate-ABC-transporter-permease
MTNLTQAAILSEPERPAASPRRKGISRKMRSSIFASYLLLILLALVYIYPFLISVAGSFKTDADSTANPLALIPQTWSFAAYERLFTDVPLPRWAMNSTIITLIVTLGRVFFDSLAGYALSRLQFRGRNLIFAGVIAVMAVPGVVLLIPRFLILKELGLYDSYGGMIIPLIIDAAGIFIMKQFFESIPISVEEAARIDGAGVFRTFWTIVLPMARPAVVTLVILSFQGSWNEFSHFIVSRSDPDLNTLTTGVAGLVSGQLGSGNQFPIVLASAMLMTIPVAVVFFIFQKRLMNTTEGAEKG
>NZ_CP017146.1|WP_161885133.1|654507_655641_+|sugar-ABC-transporter-permease
MSKGMRAGEAKFGYLFVAPAVIIIGVFLVLPIFLALYVSFSNWNGLGSPLGNSEFIGTENYQKVLVDDGLSKSDFGTSIRNNFFYVIFVVPAQTALALFLAVQVNRRVLRGRGFFRTAFYFPSVTSSIAITTIFLFLFTASGVVNSILAFFGINGPNWFKDPSGIIHNFLGVFGVNSAPAFLDVQGPLGISWWQWIAGPSVAMCALIALAVFTTSGTFMLLFLAALQNIGAEIDEAALMDGSGPFRKFFSVTLPMLKPTLFTVLTLGLIGTWQVFDQVYLTGGNGAPAKTLLTPAFLAFSTSFNELKWGQGAAISFILFAIIVALTLLQRFILRDRDVGKRAETNATRAAAEVKAGAARASARNASTNTDTTKAGIR
>NZ_CP017146.1|WP_161885132.1|653202_654441_+|extracellular-solute-binding-protein
MNKKALGAAALAVGLTASLGGCAAGSDGGGGDSAAGQELSILIASSGDAETQSVTEAANAWAADNDATVDVIVANDLNQQLSQGFAGDSAPDLFYMGWDQFSTYASNSYLEPYAADLSTAGDFYSGLVDTFTYDSTFTCAPKDFSTLGLIVNTDAWAAAGLTEADVPTDWDSLEAVATTLTTDAQVGLSFGLEYARAGAFMNQAGGQLISDDGQTVEADTPENVAGLEYIQQLHEAGVYKTPSELDSGWSGEALGKGAAAMVIEGPWIKGIKNDFPDTNYAAYELPAGPEGKSTYTFTNCWGIPQGSDTTEAATSLVEFLTSDEQQMAAADAFGVIPSTESAAALYAESYPENASFVASADYAVSPVNFAGSTSAVADFNSQLETLIGGDAQGILESFQTSLQAALDEANAQ
>NZ_CP017146.1|WP_161885131.1|652096_653206_+|LacI-family-transcriptional-regulator
MAQPTVEDVAREANVSRQTVSNVINTPSIVKPATRDRVQLAIARLGYRPNLSARRLRQRKSSTIGVRLDPIRNGISGAVLDGFVHALTEQADARSMRVLLFTAASPQDEIAQIRSLHEGADVDAFVLTATFHGDPRTAWLIENDVPFVTFGRPWGIDDMDDPKHLWVDIDGREGVKDATVRLIDNGAKRVGWVGWPRPSGTGDDRRRGWEEAMRDRLGASDAELAALSVESYDGVSEATETVVDMLRSGDLPDALVCASDTLALGALIAASSAGLTDLPIIGFDNTPVADAVGLSSVDQVLDRVAVATLELLLGSDGNSIVPRGTDAGPSHRLIRPALVLRTPNHLPLYGTTTERTAPAVRDHHRKETS
>NZ_CP017146.1|WP_161885130.1|649756_651868_-|amylo-alpha-1,6-glucosidase
MSNPVPTNTLPSPEAASPECSADSLQPLIHAETLVLRAPTQAWSAADGSMGSASIHGIFFSDMRLVNRAALRIGGQAGEAIATSTSGATSVTFVALQRHLDDRMPDPRVRSLLTRTATTSGIREDLRLESNLDTEINTTIELVLSLDLAEMDNVKSGRGAVDPAPLASVDGTGIRWSNETISAFIDAPVATVTVLGPGEVRVLWQVTVPPFGSATVGWTLSANDSRAIVHGVEEPAAWSIPTVDAADDRLGRWLAVALDDLAALRLSPASHPDRVFLAAGAPWFFTLFGRDSIWAARMMLPLGTELAADTLRVLANLQGTASVPDTAEQPGKIMHEMRRDGLTMPGEGLHLPPLYYGTVDATPLWVCLLHDAWRWGMPEDQVRELLPNVVAALEWMRDFGDADGDGLLEYVDETGHGLANQGWKDSGDSVQWRDGTLADGPIALCEVQAYAFEAATHGADLLDHFGVDGGDAWREWASVLRTRFNEGFWIDSPAGAYPAIALDASKRPVDTVTSNLGHLLGTGLLDAAQARRIADHLVSPEMSSGYGLRTMSTDSAGYWPLSYHGGSVWTHDTAIAIAGLASEGFAAEASVLVSGLLAAASGFDFRLPELHSGDPAALFSSPVPYPAACRPQAWSAASSVSILSSVLGLAPDAVAGVLGVSPAASALAPLSVTGLRFAGSAVSIVVNADGEVSRASGATIEVR
>NZ_CP017146.1|WP_161885139.1|665537_665822_+|metal-sensitive-transcriptional-regulator
MQHGYVANKEDLLKRLRRAEGQVRGIQRMIEEDTYCIDVLTQVSAATKALETVALGLLDDHLNHCVAEAAKEGGQVGEDKMREASAAIARLVRS
>NZ_CP017146.1|WP_161885140.1|665957_666188_+|heavy-metal-associated-domain-containing-protein
MTTTEYQVTGMTCGHCVASVKEEFSALEGVESVEVDLNKGGVSTVTVVSAEILPADAATAAVSEAGYELAGPLTLS
>NZ_CP017146.1|WP_161885141.1|666184_668503_+|copper-translocating-P-type-ATPase
MSLADVDLEIGGMTCGSCATRVERKLNRIEGVEASVNYATEKAHVRVPAGVDQAALIAAVESAGYTATLPAPPRAAETDAPSNAQTARENEVDALRLRLIVSALLAAPVLVLSMIPALQFTNWQWLALTLAAPVAVWGALPFHRAAWTNARHGAATMDTLISVGVTAAFTWSLYALFFGMAGVPGMTMSFQLVTEPGGGAHDIYLEVAAAVTVFILAGRYFEAKAKKESGAAMRALLELGAREATLLVGDRESTVAVDALVPGDTIVVRPGEKIATDGLIVDGASAVDASMLTGESVPVEVTVGDRVVGATVNVGGRLVVEVTRVGSDTELARLGRLVEEAQTGKAEVQRLADRVSAIFVPVVFVLAIGTFLAWTFFGSSLTVAFTAAVATLIIACPCALGLATPTALLVGTGRGSQLGILIRGPQVLEQTRRIDTIVLDKTGTITTGKMSVVDVVLADAAVGVPADAGAVSGAGSSAAALDELLRITATIENASEHPVARAIVAEARTRAIELGATESFASHQGQGVQAIVDGRLVTVGRADWLAAEWSIELPDALRDAVAAAELAGSTAVVTAWDGAARGVFVVSDTVKESSAAAIAYFKKLGLEPVLLSGDNAGAAGSVAASVGIDDVRAGITPQGKLEAIRELQSRGRVVAMVGDGVNDAAALAAADLGIAMGAGTDAAIAASDITVMSGDLVVVGDAIRLARRTLGTIKGNLFWAFAYNVAAIPIAMLGLLNPLLAGAAMAFSSVFVVSNSLRLRGFKGTPLGSRAL
>NZ_CP017146.1|WP_161885142.1|669115_672532_+|MMPL-family-transporter
MHFLSVFSLRNRALIALVTIVVAVFGSISLGLLKQELIPSVSFPQLVVVTPYPGAAPEVVNEDVSTPIETAIQGVPGLEGTTATSNTNFSTVSATFAYGTDIATADQKVTQAINRISSLLPDGIDPQVVTGSIEDLPVIQIAVTSDLSPNELTAQLENSTLNDIQGLEGVREADLLGVSEQRVQITPDAAAVAAAGVDNQAIRDALDANGTLLPAGAITENDQTLTVQTGARLGSADEIGQLPLVGATSTDGSVVTIASVSTVTVADEPVTGISRVNGEPSLTIAVTKTPAGNTVAVSEAVQELIPELEDALANNTQFTVVFDQAPFIEQSIESLATEGALGLLFAVLVILVFLLSVRATLVTAISIPASVLITFIGMYAAGYTLNIITLGALTIAIGRVVDDSIVVIENIKRHLGLGETKLVAISTAVKEVAAAITASTVTTVAVFLPLALVGDITGELFRPFALTVTIALAASLFVALTIVPVLAYWFLRAPQARKHAAPVAEGTDAASAANANAAANTNPGPAASPAASPAASPAASPAVSLAPASAQPTTAQPATAQPTTARPATAQPATAQPTTAQPTTAQPTTAQPTTAQRTTAQLTADELAEKPTRLQRGYLPIIRWTLARPVATMLIALLVLGGTAALIPLLKTNFIGDSGQNTLTVSQSVPLGTSLEAQDEAATKVEQALLDLDGVDVVQLSLGSGNDSIRQAFLGGSNITFSLTTDPEVDQVALQADVRDALAELDDVGEVSLAAAASGFASSDIEINITANGQADLGAASDAVLETVRDLDVTAEATSNLSNAQPYLAVNVDRELAAQAGLSEIAVGAIVAESKLPAAVGSVVIDEKTLSIYITNPDAPTTVQELRDFGIPSARGIIPLSEVATVEQVDGPSSITTVKGIRAATISITPNGDDVGTASAAVQAALTDADLPASADAQIGGVTAQQADAFQQLGLALLVAILIVYVVMVATFKSLRQPLLLLVSIPFAATGAIVLQVISGIPLGVPSLIGVLMLVGIVVTNAIVLVDLVNQYRERGLRVGDAIIQGASRRLRPILMTAVSTIFALLPLAVGLTGTGGFISQPLAIIVIGGLISSTALTLVVLPVLYYLVEGAKERREEKRLGLVEVESGRRRRSAHVG
>NZ_CP017146.1|WP_161885143.1|672690_672909_+|hypothetical-protein
MRTDVGGGGCCGCHDFDTAIVIGGLISSTALTLVVLPVLYYLVEGAKERREEKRLGLVEVESGRRRRSVHLG
>NZ_CP017146.1|WP_161885144.1|672933_673269_-|hypothetical-protein
MDVMQQVTSGMRVVDSDGTEVGEVENFKMGDEEAVTSRGQRDPDNGGILEGLLDAFRERSTVSPQEAERMLRIGYVVIDRKGLFAGNDHIAADRLDRVEDDTLWLKPGAAE
>NZ_CP017146.1|WP_161885145.1|673444_673993_-|cupin-domain-containing-protein
MAEQVLIGARLRAARLSKGLTLGTVASVTGLTQGYLSKLERDHVSPSVASLVAVCAAVGLRVGDLFEPPPSAIVRSGEGTLINFGAHDAREYVITPGDQTLIEVIHSFVEPEGSGGSTQYALDCDIEFIFVVSGTLDLILGDEVLSLGAGDAMTMRGREPHTWRNPSTEVGCEVLWMLAPAP
>NZ_CP017146.1|WP_161885146.1|674018_674687_-|cyclase-family-protein
MRIIKVVDLSVVVGAGTQVYPGDPEPRLTPHSTVERDGFNLLSVEMGSQTGTHVDAPYHFDESTERIDEVPLERFVGRGVIVDATDLGPRGVITWAHVEPVADSIEPGCIVLLHTGWSRHYGTAAYFDNPYLDAGACRELLARGVRTFGIDAINIDETPDSEHPGIGFPVHHLIADAGGIICENLTGLTAIDFAQPQISLLPIALEAADGAPVRAVAIQFGE
>NZ_CP017146.1|WP_161885147.1|674753_676334_+|cytosine-permease
MTQHGNDATVTLNPRPKATEVELHGINTIPDADRTSRPFDLFRIQFGGANTFATVLLGTFSIALGLSFWEAVLATVAGVLLGAVILMPMGLFGPKTGTNNAVSSGAHFGVRGRVVGSFLSLLTAIAFYSISVWVSGDAIVGALTRLAGVEDSIGLRTVIYAIIGAIVIIVVVYGYQFMLLVNKTAVIANTLLFLLALVAFATTFDPSYNPGPDAYALGSFWPTFVLAALIAMSNPISFGAFLGDWSRYIPKSTPPRKLFAATLLGQLATLVPFLFGVATATIVAGEVDYVVALIQASPPWYAVVLIFVAFIGGLSTGSTSLYGTGLDFSSVFPRFSRVQATIAIGSLAFVFILVGRLAFDLLGAVNAFVGAIIVTTTPWMIIMAIGYFVHRGEYDARMLQVFNRGETGGKYWYNGGVNWRGMVAWIAAATLGLLFAYFPPVISGPFANAAGGVDLSLIVAIGTAAVVYIGALLIFPEPSYSFGPSGPRVVRSIPGTEREVVLDHASQAARAQVRADARADASSPRG
>NZ_CP017146.1|WP_161885148.1|676263_677379_+|agmatinase
MPRRLPAPRCAPTPVPTPAPPVADATADELRDERPDHPPAQRPIPRLTTGGKLGQVDATIVPRFGGAPTFARLPRIDEVEAADVVVVGVPFDSGVSYRPGARFGPSHIRESSRLLRPYNPAQDVQPFALLQVADAGDIAANPFDIAEALMQIEEAAAVHLQAGSRLVVLGGDHTIALPLLRATAEVHGPLAVIHFDAHLDTWDTYFGADYTHGTPFRRAAEEGLLAPDSCMHLGIRGPLYSADDLTEDGDLGFQIAHATEMDSIGVAGMIERMLARVGDRPVYVSVDIDVLDPAFAPGTGTPEAGGFTSRELLAILRALSSTNLVGADIVEVAPAYDHAQITGIAAAHVVYELISSMAIQTQRLKAQEGSA

Crispr_ID: NZ_CP017146_4

• CRISPR_ID: NZ_CP017146_4
• CRISPR_location: 754653-754759
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP017146_4

Consensus_repeat	Method
CGGTGCTGCCGGTGCTGCCGCCG	CRISPRCasFinder

spacers of NZ_CP017146_4

>4.1|754676|16|NZ_CP017146|CRISPRCasFinder
AGGGGGGCGCTACGAT
>4.2|754715|22|NZ_CP017146|CRISPRCasFinder
CTGCCGGTGCTGCCGGTGCTGC

CRISPR arrays and Neighbor proteins around NZ_CP017146_4

CRISPR arrays

The CRISPR arrays of NZ_CP017146_4

>merge|NZ_CP017146|4|754653-754759|CRISPRCasFinder
CGGTGCTGCCGGTGCTGCCGCCGAGGGGGGCGCTACGATCGGCGCTGCCGGTGCTGCCGGTGCTGCCGGTGCTGCCGGTGCTGCCGGTGCTGCCGGCGCTGCCGCCC

>NZ_CP017146|4|3|754653-754759|CRISPRCasFinder
CGGTGCTGCCGGTGCTGCCGCCG	AGGGGGGCGCTACGAT
CGGCGCTGCCGGTGCTGCCGGTG	CTGCCGGTGCTGCCGGTGCTGC
CGGTGCTGCCGGCGCTGCCGCCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017146.1|WP_161885213.1|757874_758690_-|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl|CDD|376806
NZ_CP017146.1|WP_161885208.1|753274_753496_+|hypothetical-protein	unknown	unknown	gnl|CDD|223924
NZ_CP017146.1|WP_161885209.1|753554_754127_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|366166
NZ_CP017146.1|WP_161885216.1|760524_761331_-|hypothetical-protein	unknown	unknown	gnl|CDD|179898
NZ_CP017146.1|WP_161885200.1|744720_744888_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161885207.1|752946_753165_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161885202.1|746606_747092_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161885203.1|747127_747571_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161885212.1|757398_757788_-|cation-transport-regulator-ChaB	unknown	unknown	gnl|CDD|377614
NZ_CP017146.1|WP_161885204.1|747912_751005_-|SMC-family-ATPase	unknown	unknown	gnl|CDD|223496
NZ_CP017146.1|WP_161885205.1|751001_752165_-|exonuclease-SbcCD-subunit-D	unknown	unknown	gnl|CDD|223497
NZ_CP017146.1|WP_161887327.1|762188_763883_-|MFS-transporter	unknown	unknown	gnl|CDD|129794
NZ_CP017146.1|WP_161885201.1|745262_746531_+|M18-family-aminopeptidase	unknown	unknown	gnl|CDD|235073
NZ_CP017146.1|WP_161885215.1|759903_760458_-|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|235935
NZ_CP017146.1|WP_161885214.1|759037_759664_+|DUF4433-domain-containing-protein	unknown	unknown	gnl|CDD|373093
NZ_CP017146.1|WP_161885211.1|755920_757246_-|nitrate-reductase	unknown	unknown	gnl|CDD|236744
NZ_CP017146.1|WP_161885218.1|763906_764725_-|tryptophan-rich-sensory-protein	unknown	unknown	gnl|CDD|376985
NZ_CP017146.1|WP_161885217.1|761391_762177_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|366166
NZ_CP017146.1|WP_161887328.1|764854_765262_+|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
NZ_CP017146.1|WP_161885206.1|752256_752898_+|DUF1294-domain-containing-protein	unknown	unknown	gnl|CDD|377743

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP017146.1|WP_161885213.1|757874_758690_-|CPBP-family-intramembrane-metalloprotease	gnl|CDD|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	1.0609e-05
NZ_CP017146.1|WP_161885208.1|753274_753496_+|hypothetical-protein	gnl|CDD|223924	COG0855, Ppk, Polyphosphate kinase [Inorganic ion transport and metabolism].	0.00621727
NZ_CP017146.1|WP_161885209.1|753554_754127_+|alpha/beta-hydrolase	gnl|CDD|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.39682e-05
NZ_CP017146.1|WP_161887328.1|764854_765262_+|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.50968e-13
NZ_CP017146.1|WP_161887327.1|762188_763883_-|MFS-transporter	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.53781e-77
NZ_CP017146.1|WP_161885216.1|760524_761331_-|hypothetical-protein	gnl|CDD|179898	PRK04949, PRK04949, putative sulfate transport protein CysZ; Validated.	1.35016e-22
NZ_CP017146.1|WP_161885204.1|747912_751005_-|SMC-family-ATPase	gnl|CDD|223496	COG0419, SbcC, ATPase involved in DNA repair [DNA replication, recombination, and repair].	8.71726e-63
NZ_CP017146.1|WP_161885214.1|759037_759664_+|DUF4433-domain-containing-protein	gnl|CDD|373093	pfam14487, DUF4433, Domain of unknown function (DUF4433). This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 201 and 230 amino acids in length. There is a single completely conserved residue E that may be functionally important. This family is distantly similar to pfam01885 suggesting these may be ADP-ribosylases.	3.14723e-29
NZ_CP017146.1|WP_161885206.1|752256_752898_+|DUF1294-domain-containing-protein	gnl|CDD|377743	pfam06961, DUF1294, Protein of unknown function (DUF1294). This family includes a number of hypothetical bacterial and archaeal proteins of unknown function.	4.22485e-24
NZ_CP017146.1|WP_161885205.1|751001_752165_-|exonuclease-SbcCD-subunit-D	gnl|CDD|223497	COG0420, SbcD, DNA repair exonuclease [DNA replication, recombination, and repair].	6.08006e-47
NZ_CP017146.1|WP_161885201.1|745262_746531_+|M18-family-aminopeptidase	gnl|CDD|235073	PRK02813, PRK02813, putative aminopeptidase 2; Provisional.	0
NZ_CP017146.1|WP_161885215.1|759903_760458_-|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|235935	PRK07109, PRK07109, short chain dehydrogenase; Provisional.	6.99157e-47
NZ_CP017146.1|WP_161885211.1|755920_757246_-|nitrate-reductase	gnl|CDD|236744	PRK10720, PRK10720, uracil transporter; Provisional.	1.61885e-112
NZ_CP017146.1|WP_161885218.1|763906_764725_-|tryptophan-rich-sensory-protein	gnl|CDD|376985	pfam03073, TspO_MBR, TspO/MBR family. Tryptophan-rich sensory protein (TspO) is an integral membrane protein that acts as a negative regulator of the expression of specific photosynthesis genes in response to oxygen/light. It is involved in the efflux of porphyrin intermediates from the cell. This reduces the activity of coproporphyrinogen III oxidase, which is thought to lead to the accumulation of a putative repressor molecule that inhibits the expression of specific photosynthesis genes. Several conserved aromatic residues are necessary for TspO function: they are thought to be involved in binding porphyrin intermediates. In, the rat mitochondrial peripheral benzodiazepine receptor (MBR) was shown to not only retain its structure within a bacterial outer membrane, but also to be able to functionally substitute for TspO in TspO- mutants, and to act in a similar manner to TspO in its in situ location: the outer mitochondrial membrane. The biological significance of MBR remains unclear, however. It is thought to be involved in a variety of cellular functions, including cholesterol transport in steroidogenic tissues.	0.000343945
NZ_CP017146.1|WP_161885217.1|761391_762177_+|alpha/beta-hydrolase	gnl|CDD|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	2.26738e-25
NZ_CP017146.1|WP_161885212.1|757398_757788_-|cation-transport-regulator-ChaB	gnl|CDD|377614	pfam06150, ChaB, ChaB. This family of proteins contain a conserved 60 residue region. This protein is known as ChaB in E. coli and is found next to ChaA which is a cation transporter protein. ChaB may be regulate ChaA function in some way.	1.60181e-16

Protein sequences

>NZ_CP017146.1|WP_161885209.1|753554_754127_+|alpha/beta-hydrolase
MRSGLRPPLLDQGSEAPVLLIPGVFETWHYLEQLAETLHRHAHPVYFVHTLGFNSRAIDVSATLAQQFLRHRDLTGVIIVAHSKGGLIGKRMMVADDVEGRIDRMIAINTPFSGSPLARYALGRAMREFRREHPTMRTLLREERVNSRITSLFSSFDHPMAAPSKGRRTCVCRSSGISGRSGIRCSSARC
>NZ_CP017146.1|WP_161885208.1|753274_753496_+|hypothetical-protein
MTGEGVSGGGTGQSGTGQSIKGIVRDLLADIQLGHIDDDVVNVLTERLRRAGLEVRPEEVEDLAEEIENHASR
>NZ_CP017146.1|WP_161885207.1|752946_753165_-|hypothetical-protein
MADFQNEPMQDGNDSTVDEKIQGIADQVKADIDLDSADVDVSAELQQRAREAGVPLTAADADAIADDIANSQ
>NZ_CP017146.1|WP_161885206.1|752256_752898_+|DUF1294-domain-containing-protein
MAPGAERMDGTLVSWKDSRGFGFIAPANGGDDVFVHISEFVDASRRPLSGESFTFEVGATPEGKIRARRVLAIGATLDDTPTPAKRALNLGLAGYLAVAAFAVLFALIATERDLPVWTIGLYVGTSILTFLVYADDKSAAASGRWRTPEGSLLALGLVGGWPGAVIAQRMLRHKTRKMSFQLAFWGTVALNITAFVAFSSPEFLDLVARLSQP
>NZ_CP017146.1|WP_161885205.1|751001_752165_-|exonuclease-SbcCD-subunit-D
MRILHTSDWHIGRTFHGHSTVENLRVVLAALVDEVRQRAVDVVVVAGDIFDSATPAADFYTVLTSALRQLREAGATVILTSGNHDSATRLGFQSEFAQLAGIHVITRHDQLDTPVTISDEHGPVHFYGIPYLEPSLVRHLYPEAKLTTHEQVLGFAMGRVRADLAARGGRSVVLSHCFAVGVESSDVERDITSGGIDYVPAGVFDGPDYIALGHIHSRNTISERVRYSGAPLHYSFGEATRPRGAWLVQLDAAGLGEVSWVDLPIPRRLAALTGTIEELLTDARHDADADAWVSAVLTDQVRPLDGMRRLQQRFPHCVNVQHRPQVTADAGDESYAERVRGKSDNEIVADFLTFVRNGSGPSEYERKTIRDAIAVQAASDDLDEAVA
>NZ_CP017146.1|WP_161885204.1|747912_751005_-|SMC-family-ATPase
MRIRTLEIEGFGPYKQRQLVDFDRFAGDGLFLITGKTGAGKSSILDAICFALYGSVPRYDGTESNLRSDHCAADDPTRVELVFTVHDTDYRLSRSPAYDRPKKRGVGMALEKATAELAVRRGEHWEGIAAIPAQVGPEVRRIVGLTKDQFLQVILLAQNRFQEFLLAKNDDRQKVLRSLFGTHRFLDIETALVDQRKALDERLRAAREAIAVDAAHAAALLGDGEANGEPGSDSRGPTAPGESDATDATDATGESDSSAGGTAGTSIPTPLDPDLGWFEQGLAALTERLRAATDAATRADAEFTVADRAHRALEKTREQQERRDDARHRLAELEAERAAVALEREVVNLARHAAAATPQVTARRTAAAALDSARSAETVAREGYRTHFAGDRSPSTGDLRAEIDELRETLGTVSDALADEAALPALTGATDTLQRGCVDLATKVAKQIALAESRPAELEVIRSRLGEVKVLGAAEPDAAERVERLTAAEKAATTVDRLEPKLTAALAAASTASGEAAASAALVHDLMAQRLSGHAAELAGELREGEACSVCGSAEHPAPATFDGAPVTPEDIERARTAASARQADLDAAHEATKDLDRRVAEARAIAGGKASEQLRVELAEARERLATAVSAAAESADFELELWRLTAELAEAATALDQIRSDRDDAERQLVESRTRCSALEARIATHRGDFDSVAVREATLRHQLDAASALADAIAAVSTRAETLATAAAAVREVLDEHGFADESSVVDARRDASKVAAIEARIRRFDDALAAAAATLAEPAIAAVPDDTVELLPAEAARDATASARDAALAARTSLGARVEQLGTIVASARRRITASGAMLDEQRQLRELANAVEGKEPNDKRMRLETYVLAARLEEIVAAANARLRTMTSGRYALEHDDAVAYRNVQSGLGLAIRDEHSGRARATHSLSGGETFLASLALALGLAEVVQNQAGGIRLDTLFIDEGFGSLDGDTLEIAMSTLDSLRAGGRTIGLISHVEAMKEQITAHLEITVSSNGWSEIADARVLA
>NZ_CP017146.1|WP_161885203.1|747127_747571_-|hypothetical-protein
MKPPHYDPDQMLPLSTPERIEGRVLSLVGRATRREIWFLFVNHRDAQLPIILPLQDHPSFPAPGDPERFTRMLSHVGEATDAAGVIVVIERYADHMLAPSDLAWASTLHAAAAASSLILRGVLLSHARGVRWVAPDDYLFPVGGATA
>NZ_CP017146.1|WP_161885202.1|746606_747092_-|hypothetical-protein
MPFLSESSRAALDRLAQDESAESPPDPLTRVRCIRALTAALETESAMLQSVREALERGSSWNEVAEAAGLGPAAAKWRWQGTDDDITARHEAGRKRAARPSSVPTDLPGLSVSDAAARLGVTPQAVYLKVSRGTLTARTVDLADGRKYKRVFLPDDPDLEA
>NZ_CP017146.1|WP_161885201.1|745262_746531_+|M18-family-aminopeptidase
MSDSMAHLHDLADFVRASPSSFHAVEEAGRRLTAAGFVALDEMDPWERGPGKRFVIRDGAIVAWIEPASATATTGFRILGAHTDSPGFKLKPKPTTTSQGWIQAGVEVYGGPLFNSWLDRELEFAGRLVFDDGTTALVRTGPFLRFPQLSVHLDRAVNEGLKLDPQAHLNPVIGVGDPADADVVDHLAHLAGRRGSAVAGYDIVVADTAPPAVFGLGSRLFASGRLDNLSSVHAGLTALLRVPTESEHILVFAAFDHEEVGSATRSGASGPLLADVLARIKEGSSVSDQARALAASWCLSADAGHAVHPNYAERHDPANRPIVGGGPLLKINANQRYATDAVGAAEWARACGQAGVGYQEFVSNNSLPCGSTIGPLTATRLGIRTIDVGIALLSMHSARELCGVDDPAAFTDAIEAFLAPAG
>NZ_CP017146.1|WP_161885200.1|744720_744888_+|hypothetical-protein
MRDQLAATVDHNTTAGSLEHLLVRAGHGDQGAFALERLRAEDGMEVPGARQSSGA
>NZ_CP017146.1|WP_161885211.1|755920_757246_-|nitrate-reductase
MALPWKLHGDGKNVAANEIVQPEERLTWPRTIGFGAQHVVAMFGATFLVPLITGFPPATTLLFSGLGTLLFLIITKNKLPSYLGSSFAFIAPIGAAVGSGGQSVALGGVIVVGALLAIVGVIVHLSGTRWINVALPPIVSGAIVALIGFNLAPAARDNFAASPLIATITLLSIILAAVLFKGLLGRLSIVVGVAVGYVAAVIAGQIDFSGVGDAPWVGLPQFTTPSFSLEYIGVYLMFLPVVLALIAENVGHIKGVGQLTGRNLDPLTGRALFADGLATVISGIGGGSPTTTYGENIGVMAATRVFSTAAYWVAGITAILLGMSPKVGAIIFSVPPGVLGGVTTALYGLIGIIGVRIWVENRVDFSLPKNQLTAGIALIMGIANFTIVLGDVEFTGIVLGTVAAIVVYHLMNGLGKLRGTDAEAADAGADVGKRTAAGERK
>NZ_CP017146.1|WP_161885212.1|757398_757788_-|cation-transport-regulator-ChaB
MPASDEMPDTLRRSDTHAQSLWSKAHDSAVDSYGEGERAHRTAFAALKREYEKVGDHWERKAESGPSDSGAAGPRGTGQTKGGVDANASKEHLMDLARRLDVKGRSSMNKSELVDALQKANARETRTSG
>NZ_CP017146.1|WP_161885213.1|757874_758690_-|CPBP-family-intramembrane-metalloprotease
MVTVQPQVKQQLSWGLIPAAGVSASAILIFGLLNLPAGYAVLVGSLILAFVIDRSLASDLLLIGIGMGIISTISVAADISYGNMLLMGTVLTLAVLVPFLIDRYGYRRRTIVFPVRTGQKWSTLERSYLAIVLVLGWTILPFYFIGSGAYQNWPAISTPDEIARLFVGVNAVGIWDELFFICTVFALLRRHFPMWQANILQAVIFVSFLWELGYQSWGPLLTAPFALLQGYIFSKTKSLTYVVCVHLLFDLVVFLVLVHAHNREWLPIFFY
>NZ_CP017146.1|WP_161885214.1|759037_759664_+|DUF4433-domain-containing-protein
MPSLGEQRIYHVTHASNLPGILDSGALNAETSPVTDISSEEARTARRATTVAGPDSATVAEHVPFYLSPNARLWESMRAGSTDPRLAPSAHGLAAAEFVILVSTVKTVATDEASIVVTDGDATGQLTRFAATDETWKRLLYRLISDDESDALLSAEFLVKDSVPFDAVTLIGVPHDRARDAVKLALAGSSHVPRVAVHPPWFAVPTED
>NZ_CP017146.1|WP_161885215.1|759903_760458_-|SDR-family-NAD(P)-dependent-oxidoreductase
MSKRKDPVVVITGASSGIGRATALRFAKKEASLVLASRSDEALIGLVREWENLGGRAIAVPTEVAGFTDVQALAAAAAAAVEAFERIDVWVNNAGTTLFASFLEVPLEDFRRVLDVNLMGCVYGSRAAIRSLGASIRSERPGRPGNGAPAPTHPAGDRGADGRAGREDPPLAAARGAGDRRHPV
>NZ_CP017146.1|WP_161885216.1|760524_761331_-|hypothetical-protein
MDSSKTSARPPGLVWQFLGGMGYLVRGLRLWVTSPRLMLLGALPALVVGLFFATALVLFAINLESLATLITPFADRWVDPLRAGTRIAAGTALGAVTMLLAVYTFVAVTLTLGNPFYERIWRAVEQRMGDAPVEIDEPFWRSATRGIGSGIRLFALTATVGLSLFAVSFIPIVGQTAVPVLGALLGGWFLTLELTGFAFDARGLRLRDRRRMLGARRASTLGFGVLTYVLFLVPLGAVVIMPAAVAGATMLSRDALASASRQANPATS
>NZ_CP017146.1|WP_161885217.1|761391_762177_+|alpha/beta-hydrolase
MTIFDRFRRVKTPPLHVAIDEGTGPVVVLVHGIASSSVTFENLIPLITDRHRVIAVDLLGFGESLAPESATFTIEEHVEALEDTLDALRLRHPFVLVGHSMGSLIASRYAATNRKRVSKLVLVSPPVYMNPEALGDPVERAAMGLYLKAYEFLRTNQNFTMRNAAMLARISPIKNVLEVNARNWKAFVLSLQNSIESQTTVSDIASVTVPVEIIYGALDPFLMPGGLRIVEQMRLVTVHKVDASDHLVRKRLARVVAVAIG
>NZ_CP017146.1|WP_161887327.1|762188_763883_-|MFS-transporter
MHSPRARWIGLLFISIAVALIIVDSTIINVAIPSIVADLGITSTQVQWVQESYTLVFAALLLVFGALADRYGRRRILLTGVVVFASASVLAAFASSGDLLIGSRVIQGIGGAMVLPTTLSIINATFRGRDRAIAFAIWGSTIGGMVAVGPLLGGWLTTYYSWRWAFGINVPLGIIIIVGVLLYVIESKDAGEPRRIDVVGAILSVVTSASLVFGLIEGRTFGWWTTNDAPTIGAWTWPFDVSPIPLVFLVTIVSGIAFVRWGLRRQRAGASTLLAFGLFRIASFRNGNIAALIVSLGEFGIILSLPLWLQNVLGYTALQTGFVLLALAIGSFVASGVAGALANRVSPETIVRIGLIAEIVGVVGLGVAISPDATWLSIVPFLFVYGLGVGLATAQLTSVVLRDVPVAQSGQGSGTSSTARQIGSALGIAVLGTILFTSVGASLDAKLSDLPAESRSQIVATVVDSAGAAIPSLDAQGAEIADAARAAFSEGTRYSAFAAAGFLVVGLLATLRLSARRHEPEEDNLQEGKPAEDDPQEGRPDEPAESDPSDEPAATEEPTRPAAT
>NZ_CP017146.1|WP_161885218.1|763906_764725_-|tryptophan-rich-sensory-protein
MTSATVHTGNDLLRQSVVAASAVIAIVGSFIGSGAAGGTPIQDAAGGALATDATLIAPGGAAFGIWSVIYVGLIAYAIWQFLPAQKSDPRQRLLGYPIAASLILNAAWILSIQFDLLPLSVPVIVLLLAVLVYTFRMTIVTRPRTLVEALVADGTVGLYLGWVCVATAANITAWLVTTGFDGFGLDADAWAVGVIAVAGLVGVLLAFRGRGRLGPAISLSWGLAWVAVARLTGDLVSQPAAAAALVSVLAVIGFTVALRLMTPPLPASAVTT
>NZ_CP017146.1|WP_161887328.1|764854_765262_+|MarR-family-transcriptional-regulator
MESWPTGRLLSTAARLVENAWYESLENLGLSHTGLVALHHLGEGPMSQTELARRARVNNQNLSRTLEQLETDGYIVRVQSPRDARRRVVTRTPAGSSIWTTAQHLEANMFPPAPETKELRRALLEIIAASPARRW

Crispr_ID: NZ_CP017146_5

• CRISPR_ID: NZ_CP017146_5
• CRISPR_location: 819069-819177
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP017146_5

Consensus_repeat	Method
GCAGATGTGGGCGACTCGCGGTTGGA	CRISPRCasFinder

spacers of NZ_CP017146_5

>5.1|819095|57|NZ_CP017146|CRISPRCasFinder
GGTTCTTTTGTATCCCGCGAGTTGCCTGCTTGTGTCGGGTTCGAAGCGTTGAAGGCA

CRISPR arrays and Neighbor proteins around NZ_CP017146_5

CRISPR arrays

The CRISPR arrays of NZ_CP017146_5

>merge|NZ_CP017146|5|819069-819177|CRISPRCasFinder
GCAGATGTGGGCGACTCGCGGTTGGAGGTTCTTTTGTATCCCGCGAGTTGCCTGCTTGTGTCGGGTTCGAAGCGTTGAAGGCAGCAGATGTGGGCGACTCGCGGGTTGG

>NZ_CP017146|5|4|819069-819177|CRISPRCasFinder
GCAGATGTGGGCGACTCGCGGTTGGA	GGTTCTTTTGTATCCCGCGAGTTGCCTGCTTGTGTCGGGTTCGAAGCGTTGAAGGCA
GCAGATGTGGGCGACTCGCGGGTTGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017146.1|WP_161885269.1|824927_825248_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161885271.1|825731_826130_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|378935
NZ_CP017146.1|WP_161885264.1|817462_818911_+|26S-protease-regulatory-subunit	unknown	unknown	gnl|CDD|224143
NZ_CP017146.1|WP_161885267.1|821689_822565_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|366166
NZ_CP017146.1|WP_161885257.1|809138_810008_+|pantoate--beta-alanine-ligase	unknown	unknown	gnl|CDD|376824
NZ_CP017146.1|WP_161885256.1|808311_809007_+|DUF2520-domain-containing-protein	unknown	unknown	gnl|CDD|287672
NZ_CP017146.1|WP_161885262.1|816207_816855_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161885259.1|812698_812941_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161885255.1|806545_808315_+|PH-domain-containing-protein	unknown	unknown	gnl|CDD|225962
NZ_CP017146.1|WP_161885270.1|825281_825656_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161885258.1|810790_812317_+|lysine--tRNA-ligase	unknown	unknown	gnl|CDD|234778
NZ_CP017146.1|WP_161885273.1|829555_831004_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NZ_CP017146.1|WP_161885260.1|813096_815583_+|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl|CDD|223616
NZ_CP017146.1|WP_161885263.1|816893_817304_+|dehydrogenase	unknown	unknown	unknown
NZ_CP017146.1|WP_161885268.1|823701_824226_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161887333.1|828017_829544_-|GMC-family-oxidoreductase	unknown	unknown	gnl|CDD|225186
NZ_CP017146.1|WP_161885265.1|819310_820672_-|DNA-repair-protein-RadA	unknown	unknown	gnl|CDD|236994
NZ_CP017146.1|WP_161885272.1|826284_827520_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|379062
NZ_CP017146.1|WP_161885266.1|820777_821548_-|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|379207
NZ_CP017146.1|WP_161885261.1|815684_816194_+|amino-acid-N-acetyltransferase	unknown	unknown	gnl|CDD|236132

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP017146.1|WP_161885264.1|817462_818911_+|26S-protease-regulatory-subunit	gnl|CDD|224143	COG1222, RPT1, ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones].	7.24455e-22
NZ_CP017146.1|WP_161885258.1|810790_812317_+|lysine--tRNA-ligase	gnl|CDD|234778	PRK00484, lysS, lysyl-tRNA synthetase; Reviewed.	0
NZ_CP017146.1|WP_161885257.1|809138_810008_+|pantoate--beta-alanine-ligase	gnl|CDD|376824	pfam02569, Pantoate_ligase, Pantoate-beta-alanine ligase. Pantoate-beta-alanine ligase, also know as pantothenate synthase, (EC:6.3.2.1) catalyzes the formation of pantothenate from pantoate and alanine.	9.06967e-133
NZ_CP017146.1|WP_161885256.1|808311_809007_+|DUF2520-domain-containing-protein	gnl|CDD|287672	pfam10727, Rossmann-like, Rossmann-like domain. This family of proteins contain a Rossmann-like domain.	5.90028e-41
NZ_CP017146.1|WP_161885271.1|825731_826130_-|helix-turn-helix-domain-containing-protein	gnl|CDD|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	5.18907e-07
NZ_CP017146.1|WP_161885255.1|806545_808315_+|PH-domain-containing-protein	gnl|CDD|225962	COG3428, COG3428, Predicted membrane protein [Function unknown].	1.42873e-32
NZ_CP017146.1|WP_161885267.1|821689_822565_+|alpha/beta-hydrolase	gnl|CDD|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	4.37197e-23
NZ_CP017146.1|WP_161885273.1|829555_831004_-|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.16336e-14
NZ_CP017146.1|WP_161885260.1|813096_815583_+|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl|CDD|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP017146.1|WP_161887333.1|828017_829544_-|GMC-family-oxidoreductase	gnl|CDD|225186	COG2303, BetA, Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism].	4.09039e-44
NZ_CP017146.1|WP_161885265.1|819310_820672_-|DNA-repair-protein-RadA	gnl|CDD|236994	PRK11823, PRK11823, DNA repair protein RadA; Provisional.	0
NZ_CP017146.1|WP_161885272.1|826284_827520_-|AAA-family-ATPase	gnl|CDD|379062	pfam13191, AAA_16, AAA ATPase domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	0.0039823
NZ_CP017146.1|WP_161885266.1|820777_821548_-|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|379207	pfam13472, Lipase_GDSL_2, GDSL-like Lipase/Acylhydrolase family. This family of presumed lipases and related enzymes are similar to pfam00657.	3.83803e-25
NZ_CP017146.1|WP_161885261.1|815684_816194_+|amino-acid-N-acetyltransferase	gnl|CDD|236132	PRK07922, PRK07922, amino-acid N-acetyltransferase.	1.72471e-98

Protein sequences

>NZ_CP017146.1|WP_161885264.1|817462_818911_+|26S-protease-regulatory-subunit
MDSEQRSFIELFRTFLEEVVFTSVRDSALTPLGELVQDYLGVDIATLPAVTETIGGHRLIDADIALAHLAARGESRLVGVTNGQMRWQEDLPGLLVSRATFAPGPVDYASVASGPDSERQMVTFGLRMLEFDGHRIALLQRSARPDFGQAHARIEVLAASPDIASAVIHEIREQMIRLSVLRGQVLSLIGNEYGQGAAGATFLARPTVTAEEIVLADGVLEQVRRHVVGIGEQRARLTSAGQHLKRGVLLYGPPGTGKTLTVRHLLASTPGTTAVLLTGASIRFITEAAELARAMQPAIVVLEDVDLVAGDRSMHGGPQPLPFAVLDALDGLDGDADVTFLLTTNRVELLERALAERPGRVDLAVEIGLPDVAERRRLFALYARALPLSAEAVEAAADRADGVTGSFAKELMRRAVLTAAEQSREVTDVDLQASLEDLLSAREALTRSMLGGSGVPHGGDGVHYSASYGTPMSSSLTIEPDE
>NZ_CP017146.1|WP_161885263.1|816893_817304_+|dehydrogenase
MPNASRHPHPRKAQPKLPAAKQLAEALAAADTAAVAFALRNDAVIVPLLPVDGLAQVRVFRASVEDPFTLLLFSSAENYVRMLPEETDLRVLRYGRAQLVEFMEKHLDTLGTVWFDVAGPHPMQADPVELLAALTL
>NZ_CP017146.1|WP_161885262.1|816207_816855_+|hypothetical-protein
MSTFRNPVGPQPRSVYWRRRLVVLLGVVAVIVLVVFLVSRPGSGEASSGIPNPSASPTQDAESAAEPEPEASVPPEDQPVEGADCDPANVVVEAITDKASYAPGEQPQLSFSITNTSVVSCTYNVGTTQQLFTVTSGADQYWSSEDCETGAVDAPILLEPNLAQSSEPIPWDRTRSSADTCDSDRPAAPGGGATFNLNVTVGAASPAVPTSFLLN
>NZ_CP017146.1|WP_161885261.1|815684_816194_+|amino-acid-N-acetyltransferase
MGDNEFSVRWARTSDVPHIQTLVEPLVNRRILLGKDSVVFYGTIQGFRIVEDSTGTPIGCGALHVMWQDLAEVRTLAVQPEWLHRGIGHALLDQLEADARELGLSRLFCLTFEVDFFARHGFVPMGEEQMAPDVYAELLRSPDEGVAEFLDLARVKPNTLGNTRMIKVL
>NZ_CP017146.1|WP_161885260.1|813096_815583_+|ATP-dependent-Clp-protease-ATP-binding-subunit
MFERFTDRARRVVVLAQEEAKMLNHNYIGTEHILLGLIHEGEGVAAKALESLGIALDAVREQVQDIIGQGQQQPTGHIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGADLNKVRQQVIQLLSGYQGKEQVAVGGNDSQAQQAGSQVLDQFGRNLTQAARDGKLDPVIGREKEMERVMQILSRRSKNNPVLIGEPGVGKTAVVEGLAQAIVRGDVPETLKDKQLYTLDLGSLIAGSRYRGDFEERLKKVTKEIRTRGDIITFIDEIHTLVGAGAAEGAIDAASILKPLLARGELQTIGATTLDEYRKHFEKDAALERRFQPVQVHEPSLPHTINILKGLRDKYESFHKVSITDGAIVAAANLADRYVADRFLPDKAIDLIDEAGARLRLSILSAPPELREFDDRIAAVRGQKEGAIEDQDFEKAASLRDEEKKLLGERLRLEKQWKSGESGATGTVDEGVIAEVLAAATGIPVFKLTEEETSRLVFMEKALHQRVIGQEEAISALSKTIRRTRAGLKDPRRPSGSFIFAGPTGVGKTELAKALAEFLFDDENALISLDMSEYGEKHTVSRLFGAPPGFVGFEEGGQLTEKVRRKPFSVVLFDEIEKAHPDIFNSLLQILEEGRLTDGQGRVIDFKNTVIIMTTNLGTKDISGTPIGFTSSTDTATGYDRMRGKVIEELKKHFKPEFLNRVDETIVFPQLSPEELLQIVDLFVKRLSDRLLDRDMTADLTVSAKEQLIKVGFDPSLGARPLRRAIQHEVEDRLSERILQGELNAGDHVHVDYIDGEFVFTTGRQPGRASLEEEIAALEA
>NZ_CP017146.1|WP_161885259.1|812698_812941_+|hypothetical-protein
MPRVPVPSGPAYPETVLENFWANAAFSVTPTILVGLIFWLVMRTILRADRTERKIYAEMESAERARRGLPADGPAPKTDA
>NZ_CP017146.1|WP_161885258.1|810790_812317_+|lysine--tRNA-ligase
MTDTMPQPSEAEAAAQALAELQEISEQTAVRLAKRERLIASGGEAYPVGVPITTTIPAVRAKFPDLEADAATGDIVGLAGRVVHSRNTGKLCFASLQSGDGSRIQAMVSLAEVGQEKLDGWKDLVDLGDHVFVAGEVISSRRGELSIMVTDWMIAAKAIRPLPNLHTDLSEETRVRSRYLDLIAREGARTMVRSRAAAVASLRTTFARHDYVEVETPMLQTMHGGASARPFATHSNAFDTELFLRIAPELFLKRAVVGGIDRVFEINRNFRNEGADSTHSPEFAMLEAYQSYGDYHQMATLTQEMVQNAALDVAGSHVATWADGTEYDLGGEWDRIGMYDSLSAAAGEQITPQTPFVELLAHAARLEIEVPHPTHGKLVEELWEHYVKPGLVRPTFVLDFPVDTSPLVRDHRTTSGVVEKWDLYIRGFELATGYSELVDPVIQRERFVEQAQLAAGGDVEAMRLDEEFLRALEHGMPPTGGMGMGIDRLMMALTGLGIRETILFPLVK
>NZ_CP017146.1|WP_161885257.1|809138_810008_+|pantoate--beta-alanine-ligase
MPVVVETIAGLRSQLRQAKAHAAAEGPTRPRVALVPTMGALHEGHMALVERAQERAEIVVVSIFVNPLQFGASEDLDLYPRTVESDVERLRTHGVQIVFAPTLSEMYPAGDVPTKVTAGDIGNLYEGRSRRGHFDGVLTVVAKLLHVVGPDTVVFGQKDAQQVFLVKRMISDLNFDVQVATVPTVREDDGLALSSRNRFLDARERIAARALSRALEAAESSADRGPDAVLAAAQSVLAGDDTVQLDYLQVVNPATFLPADDNHHGRAIVLVAARIGDTRLIDNATIQLG
>NZ_CP017146.1|WP_161885256.1|808311_809007_+|DUF2520-domain-containing-protein
MTPAPHQRSGRLGVGIVGSGHVGPILGAALAGAGHAIVGISAISAASLERADAILPGVPILPVPEVVERSELVILAVPESELEALVAGLAATKAWQPGQLVMHTVARFGTGVLAPAVALGAIPLAIHPAMAFTGTSVDLARLVESHFAVTAAAPVQPIGQALVVEMGGEPVIVAEADRPAYAEAIATATSFSAAIVEQATGILSEIGIEAPGRLLAPLVRTSVENALRRAP
>NZ_CP017146.1|WP_161885255.1|806545_808315_+|PH-domain-containing-protein
MTDEGERPAHGRRAAGVPLDRGEPVTELAASLSDGEWHHLHPASPLLKGGIVLIAVIGIVISNLRERFFENFVPGANFRGDDPIELLFQEGVFGWALLALLGVLSVLVLGFYISWRMHTFRITDEVVEVRSGVLFRTNRKARLDRIQGINIVRPFFARLFGAARLEVNQAGQDANVRLDYLGSAAADDLRREILRLASGTRAASVARANGVGPGVGAGPSLAAGPSLGAAASIVEQRMHEFLAPELDPDAAEPESVVKLGTGRLIGSILLSGASVFLVVAIVAVIVASVFAPESLFVFFGLVPAVLGVAGFYVQRFMKSLRYSIAGTPDGVRVGFGLLTTSNETLPPGRIHSVKVSQPLLWRGPGWWEVKVNRASQSSTNGAAGQQNTTILPVGNLADVARVLALVLPDLLDEGLALTGLTGPGAPDDGFTNSPGRAQGLRWFSWRRNGFAVTPTAVLLRKGAIWRELVLVPHPRLQSVSVQQGPLLRMLRLAAVRLHTVTGPISAELGAVDRDAAVELFTLTAESAVRASGSDTSHRWRSAEGVDYRDGVDAGPVDRPSVIDAAGWAAPDAGTAAPAPDAGSHDRPLL
>NZ_CP017146.1|WP_161885265.1|819310_820672_-|DNA-repair-protein-RadA
MAKTQSNFTCTECGWATLKWAGRCGECQAWGTVVEAGQSTGSLRAVKPVRVSEARIARSIIDIESDSVAHWPSGINEFDRVLGGGIVPGATILLSGEPGVGKSTLLLEVASRAAAGGAKVLYVTAEESVNQVRLRAQRTNALQPSLFLAAETDLATILGQIDQVKPHLLIVDSVQTVSSSLSDGLAGGPSQVREVAATLIRVSKDRNLPILLVGHVTKDGTIAGPRLLEHLVDVVLQFEGDRQTSLRFVRSHKNRFGSTDEVGCFEMTGDGIAEVADPSGLFLSRGKVAVSGTCVTIAVEGRRALPVEVQALIVKSSAPQPRRVVNGVDASRVAMLLAVLERRAGLALSGYDVYVSTVGGIRVTEPGADLAIALAIASAYKDRPFAGSLAAVGEISLAGEVRQASSSKQRSAEAARLGFSTVVDASAGHLGEAVRLAFATASAAVERVAIPEF
>NZ_CP017146.1|WP_161885266.1|820777_821548_-|SGNH/GDSL-hydrolase-family-protein
MPSARLVAVAVVGSAALLTGAATVGRYLVIRRRTAGMVRLADMIPVHSAHWREQQKAKGEVLYVAIGDSAAQGIGASKPGRSYVGLLARSIRRETGRTVRVVNLSQSGARLREALEHLMPRLAKLQPDVVTVSIGANDIASFDPERFERELRELYSALPPAAIVADLPSFYLGESERRVRIANEVVRRVAAELSLEVAPLHRTTLGRTAARTALRDVAADFFHPNDRGYAVWASAFEPLVLRAAQALDPGTPSTRS
>NZ_CP017146.1|WP_161885267.1|821689_822565_+|alpha/beta-hydrolase
MRTTEFAHSSGRLIGVVEFGDPDAARTVVLSHPAPGSAQFDPDPAVTDAHGIRLIALDRPGYGTSGLHADGSAGTVADAADDIAEYLAAHGIGRVGAVGWSAGGRVALALAARHPQLVDRVAVVATPAPDAEVPWVGEENRAMNAQLAALPPGEATASLRAQFANLVGEYPRGIDIVGMLSADEADAALLEQIRDRLVAMLDRAVLHSVRGIAADIVSYSVRDLDFDERDLRAPTLLVYGLADSVVGAEHGRWHLAKVPHSELELIPGAGHLVIVPRWDRILRHVAPESGA
>NZ_CP017146.1|WP_161885268.1|823701_824226_-|hypothetical-protein
MADENGWPLDWLNTNAGKFIPRYGADPEWETIYSSDDITVEVASSPALPAMKLNASRPGRDTQDIAKLLALWEIPDIEAAEQLLSQFYPGDGLPDRALRILGPVFAQRLPAAPETPPFPVLGLLSQAHGEENYGAPDAHLPRPPLSFRSGARHFPELVTHGDGHQDANDGPQLG
>NZ_CP017146.1|WP_161885269.1|824927_825248_-|hypothetical-protein
MTAAASTVWYSSEWVTTGSRGYIVNAVPTALGRQQIAWNLHYIHVQHLKTILGSQAYRVNYNIEQQFVCHVVGAFLDTGVHNMESWQPSLPWQQISNPWDRCNRIK
>NZ_CP017146.1|WP_161885270.1|825281_825656_+|hypothetical-protein
MVSGGFEGRVYCLKLDWGELAEAALPPQPPTLPVDPVIPLFFSTGIAVAVLIVNYPGSWAAGVIIAFAFFTGGALSSGIVWKHHPLVANLSYWDRVRFAFRNSRVLREQSFADQEPLESEAVSR
>NZ_CP017146.1|WP_161885271.1|825731_826130_-|helix-turn-helix-domain-containing-protein
MDETVRRDAELFIERAHDRNVTQGSLTLDDGTTLQLDRKLAELVQFVIRGLPSGTVSVHAVPAEMTSTTAASVLGVSRPTLMKMVKDDLLASHKVGAHHRFKHTDVADLAEVRRAARLEAFTELRELDEALE
>NZ_CP017146.1|WP_161885272.1|826284_827520_-|AAA-family-ATPase
MRTALNSPFTPGSDSVPEVWAGRTAQLSDWRDVLRPRRQAGLAERGRTILGEAGLGKSTLVRRIARDAAAAGDWVTPQLRIPAGADPLKMIAAALLKLADQAGLAASREQRIKDTLGRVQAVAVSGLSLTLRQHDGPELYTVLTQLLVEIGRAAIARGNVVVLIHVDEVQNITDEKALSQLLIALGDALVHEEPIAAPGGVTVLRSLPIAVYLTGLPDFADTAGSRIGATFARRFKTTTLSAIDDEDLASAVQPFVIEGWPVADDLGGISRIRMDPDAAAAITEICRGEPFLFQLAGEQAWYAGTGDVISRAEAIKGWRAVRAEAVIHVERILERLPKRESDFLRAMADLPAKERTLTRIATDMGLAKATDAGPTSQRLDSVRGIIERGKPYTFRHRAVEAYLTSDWPDVE
>NZ_CP017146.1|WP_161887333.1|828017_829544_-|GMC-family-oxidoreductase
MREYEQHDVVDVVVVGTGAGGAPLLARLAERGLRVVALEAGPNLDPDDFTNDEVEAPRINWMSERLSGGDAPTAFGPNNSGWGVGGGTLHWGAFTPRPDIRELNLLTEFGVGADWPVDHAELIRYIVDVERTIGVSGPTGYPWDPEREYLEPPVDRNASADIMATGCARLGIRATDAPAAILSRDRDQAHHGRRLASRNLGTIHQGERFGTKATTANTYLPSAVAAGAEIRPDSMVHGTERDNLGRISAVVYRQNGQDFRQRCATLVLAGGGIETPRLLLNTGLANSSGLVGRNFLTHGAVQVWGRFDKQIRGYRGYPSALISEDFVRPDGVDFVGGYLLQSLGVMPLAYATSLVRGAGLWGNELVDALDAWRYTAGIGINGECLPAENNKLVLGDEVDEWGIPRAVVTFTPGPNEQSIDAHATATMTRILEAAGALDTRVLARTCHTLGTCRMSADPGDGVVDADGRSHDIPNLWISDNSTFPSSLNANPGLTQMALSLRTADRMLR
>NZ_CP017146.1|WP_161885273.1|829555_831004_-|alpha/beta-hydrolase
MTNHDGTIFFLPGLGFGSASAAPLAAALGDRFRVVGIDLPGHGRTPDAVDGSVSTLADAAVTAIEAKADGGPWLLAAHSMGGKVAALVAARVLSGHANVFGLAGVVLLAPSPPTPEPMDDDTRALMLSWAENGPLAEVDARKFIAQNVASSLDAAVEQDAVGQVRQMSPLAWQRWLNEGSRENISATVGVIDLPVVVMAGEDDDDLGASAQPRLLGAVYPRARFVSLPATGHLLPYEQPHKVAVEIVRLWESTAAASPEVDPEWGRVIASHRTGVEERSLLARRAVADDLNYRPRALSPGQLATLRALADRLVPQSEARRIDLAARVDADLASGRGDGWRPFGLPDDASAYRLGLDAIAAVWADGVAQQDALIRRIIAGELITGAPWGGEVFGRWFEDLRTDLTRTWMAHPASLSRIGYDGFATSGPGAEPAGYVSLGAGVRDPWEPADLGTLLSDTADESDGSGDRGATNNTGQARRENAA

Crispr_ID: NZ_CP017146_6

• CRISPR_ID: NZ_CP017146_6
• CRISPR_location: 843055-843175
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP017146_6

Consensus_repeat	Method
CCGATCCTGGAGCCGATCCTGGAGCCGA	CRISPRCasFinder

spacers of NZ_CP017146_6

>6.1|843083|17|NZ_CP017146|CRISPRCasFinder
GGCTGGAGCGTCCGCAT
>6.2|843128|20|NZ_CP017146|CRISPRCasFinder
TCCTGGAGCCGATCCTGGAG

CRISPR arrays and Neighbor proteins around NZ_CP017146_6

CRISPR arrays

The CRISPR arrays of NZ_CP017146_6

>merge|NZ_CP017146|6|843055-843175|CRISPRCasFinder
CAGAGGCGGGAGCCGTGCCCGGGGCCGAGGCTGGAGCGTCCGCATCCGATCCTGGAGCCGATCCTGGAGCCGATCCTGGAGCCGATCCTGGAGCCGATCCTGGAGCCGATCCTGCAGCCGA

>NZ_CP017146|6|5|843055-843175|CRISPRCasFinder
CAGAGGCGGGAGCCGTGCCCGGGGCCGA	GGCTGGAGCGTCCGCAT
CCGATCCTGGAGCCGATCCTGGAGCCGA	TCCTGGAGCCGATCCTGGAG
CCGATCCTGGAGCCGATCCTGCAGCCGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017146.1|WP_161885276.1|835270_836740_+|MFS-transporter	unknown	unknown	gnl|CDD|129794
NZ_CP017146.1|WP_161885275.1|833274_835014_-|FAD-binding-protein	unknown	unknown	gnl|CDD|235758
NZ_CP017146.1|WP_161885279.1|838986_839754_+|protocatechuate-3,4-dioxygenase-subunit-beta	unknown	unknown	gnl|CDD|131475
NZ_CP017146.1|WP_161885290.1|847709_848210_+|metallophosphoesterase	unknown	unknown	gnl|CDD|223695
NZ_CP017146.1|WP_161885277.1|836890_837694_+|IclR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224332
NZ_CP017146.1|WP_161885288.1|846550_846856_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161885286.1|844711_845941_+|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl|CDD|235741
NZ_CP017146.1|WP_161885292.1|849287_850679_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_CP017146.1|WP_161885285.1|844034_844715_+|CoA-transferase-subunit-B	unknown	unknown	gnl|CDD|188219
NZ_CP017146.1|WP_161887335.1|847486_847672_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161887334.1|831000_831894_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187613
NZ_CP017146.1|WP_161885287.1|846123_846528_+|cytochrome-c-oxidase-subunit-4	unknown	unknown	gnl|CDD|378833
NZ_CP017146.1|WP_161885282.1|841792_842581_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|131480
NZ_CP017146.1|WP_161885280.1|839746_840307_+|protocatechuate-3,4-dioxygenase-subunit-alpha	unknown	unknown	gnl|CDD|239546
NZ_CP017146.1|WP_161885291.1|848520_848922_+|YchJ-family-protein	unknown	unknown	gnl|CDD|225557
NZ_CP017146.1|WP_161885274.1|832000_833263_-|hypothetical-protein	unknown	unknown	gnl|CDD|223492
NZ_CP017146.1|WP_161885281.1|840299_841796_+|3-carboxy-cis,cis-muconate-cycloisomerase	unknown	unknown	gnl|CDD|176469
NZ_CP017146.1|WP_161885289.1|846870_847155_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161885278.1|837785_838967_+|4-hydroxybenzoate-3-monooxygenase	unknown	unknown	gnl|CDD|236198
NZ_CP017146.1|WP_161885284.1|843239_844031_+|CoA-transferase-subunit-A	unknown	unknown	gnl|CDD|224702

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP017146.1|WP_161885276.1|835270_836740_+|MFS-transporter	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	6.6165e-62
NZ_CP017146.1|WP_161885275.1|833274_835014_-|FAD-binding-protein	gnl|CDD|235758	PRK06263, sdhA, succinate dehydrogenase flavoprotein subunit; Reviewed.	4.03956e-163
NZ_CP017146.1|WP_161885279.1|838986_839754_+|protocatechuate-3,4-dioxygenase-subunit-beta	gnl|CDD|131475	TIGR02422, Protocatechuate_34-dioxygenase_beta_chain, protocatechuate 3,4-dioxygenase, beta subunit. This model represents the beta chain of protocatechuate 3,4-dioxygenase. The most closely related family outside this family is that of the alpha chain (TIGR02423), typically encoded in an adjacent locus. This enzyme acts in the degradation of aromatic compounds by way of p-hydroxybenzoate to succinate and acetyl-CoA. [Energy metabolism, Other].	1.17346e-124
NZ_CP017146.1|WP_161885290.1|847709_848210_+|metallophosphoesterase	gnl|CDD|223695	COG0622, COG0622, Predicted phosphoesterase [General function prediction only].	1.14549e-37
NZ_CP017146.1|WP_161885277.1|836890_837694_+|IclR-family-transcriptional-regulator	gnl|CDD|224332	COG1414, IclR, Transcriptional regulator [Transcription].	6.7192e-58
NZ_CP017146.1|WP_161885286.1|844711_845941_+|acetyl-CoA-C-acetyltransferase	gnl|CDD|235741	PRK06205, PRK06205, acetyl-CoA C-acetyltransferase.	0
NZ_CP017146.1|WP_161885285.1|844034_844715_+|CoA-transferase-subunit-B	gnl|CDD|188219	TIGR02428, 3-oxoadipate_CoA-transferase_subunit_B, 3-oxoacid CoA-transferase, B subunit. Various members of this family are characterized as the B subunits of succinyl-CoA:3-ketoacid-CoA transferase (EC 2.8.3.5), beta-ketoadipate:succinyl-CoA transferase (EC 2.8.3.6), acetyl-CoA:acetoacetate CoA transferase (EC 2.8.3.8), and butyrate-acetoacetate CoA-transferase (EC 2.8.3.9). This represents a very distinct clade with strong sequence conservation within the larger family defined by pfam01144. The A subunit represents a different clade in pfam01144.	1.3059e-117
NZ_CP017146.1|WP_161885292.1|849287_850679_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	7.05809e-82
NZ_CP017146.1|WP_161887334.1|831000_831894_-|SDR-family-oxidoreductase	gnl|CDD|187613	cd05355, SDR_c1, classical (c) SDR, subgroup 1. These proteins are members of the classical SDR family, with a canonical active site tetrad and a typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.49951e-139
NZ_CP017146.1|WP_161885287.1|846123_846528_+|cytochrome-c-oxidase-subunit-4	gnl|CDD|378833	pfam12270, Cyt_c_ox_IV, Cytochrome c oxidase subunit IV. This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length. This family is the fourth subunit of the cytochrome c oxidase complex. This subunit does not have a catalytic capacity but instead, is required for assembly and/or stability of the complex.	6.50993e-33
NZ_CP017146.1|WP_161885282.1|841792_842581_+|alpha/beta-fold-hydrolase	gnl|CDD|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	1.19055e-76
NZ_CP017146.1|WP_161885280.1|839746_840307_+|protocatechuate-3,4-dioxygenase-subunit-alpha	gnl|CDD|239546	cd03463, 3,4-PCD_alpha, Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion bound in the beta-subunit at the alpha-subunit-beta-subunit interface. 3,4-PCD is a member of the aromatic dioxygenases which are non-heme iron intradiol-cleaving enzymes that break the C1-C2 bond and utilize Fe3+.	9.48391e-65
NZ_CP017146.1|WP_161885274.1|832000_833263_-|hypothetical-protein	gnl|CDD|223492	COG0415, PhrB, Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair].	1.86132e-21
NZ_CP017146.1|WP_161885281.1|840299_841796_+|3-carboxy-cis,cis-muconate-cycloisomerase	gnl|CDD|176469	cd01597, pCLME, prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like. This subgroup contains pCLME and related proteins, and belongs to the Lyase class I family. Members of this family for the most part catalyze similar beta-elimination reactions in which a C-N or C-O bond is cleaved with the release of fumarate as one of the products. These proteins are active as tetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits. CMLE catalyzes the cyclization of 3-carboxy-cis,cis-muconate (3CM) to 4-carboxy-muconolactone in the beta-ketoadipate pathway. This pathway is responsible for the catabolism of a variety of aromatic compounds into intermediates of the citric cycle in prokaryotic and eukaryotic micro-organisms.	1.05264e-102
NZ_CP017146.1|WP_161885291.1|848520_848922_+|YchJ-family-protein	gnl|CDD|225557	COG3012, COG3012, Uncharacterized protein conserved in bacteria [Function unknown].	4.92871e-46
NZ_CP017146.1|WP_161885278.1|837785_838967_+|4-hydroxybenzoate-3-monooxygenase	gnl|CDD|236198	PRK08243, PRK08243, 4-hydroxybenzoate 3-monooxygenase; Validated.	0
NZ_CP017146.1|WP_161885284.1|843239_844031_+|CoA-transferase-subunit-A	gnl|CDD|224702	COG1788, AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism].	2.17623e-91

Protein sequences

>NZ_CP017146.1|WP_161885282.1|841792_842581_+|alpha/beta-fold-hydrolase
MTKPTIRGTIQEVVGNVGEQQMIVLGPSLGTTSSLWDGVVPALAEHYRVLRFDLPGHGLSPAATEPFSIADIADAVITLVDSVGGGPFFYAGISLGGAVGLELALRHPDRMLGLAVICSGAKIGAAEGWVERAGQIRTSGTASVVASSADRWFAPGFLERDPAAGSAALSALIDVDDESYALCCEALSAFDVTDEVTGIRAKTLCVSGEFDLPTPTAQLQELADSIPGARHVTISGVAHLPALERPDTVAALLLRAVEVAND
>NZ_CP017146.1|WP_161885281.1|840299_841796_+|3-carboxy-cis,cis-muconate-cycloisomerase
MPDHSLLDPLAHGTRAAELTSDAAFLQAMVDAELALTASLIDAGLVPGWMSAVCAELADASRLDLAAITAEGRAGGNPVIPLVKHLGARAEELRAGASDHLHVGATSQDILDTAAMLVGHRVCGEVLASLGTLADRLARLVGDNRDTRLAGRTLGQQASPTTLGFIAAGWLDAVLHATAALERVRGSLPAQLGGAVGTLSVLTTIAIARRQGTPPAETVDLVVSGFAGRLDLAEAPIAWHTNRLIICDLATALAAATGAAGAFALDVTVLSRTEIGELGEELAPGQGGSSAMPHKRNPVTAVLVTAAARQAPGLVATLLGSLLAEDQRPSGAWHAEWTALRTLESVAIAATTGAAHLAGRLHVDRERMQANLGLTDGLVFSEQVTTILAEALGKTAAFALVERAALEAATTTRPLQIVLSAHLAGDSPITRAIDDSLRARVWSAFTPGATDGAAGLGHTAAGIDRVLRRYRGCALSPGVTARTESVAPPTDDEGTPAT
>NZ_CP017146.1|WP_161885280.1|839746_840307_+|protocatechuate-3,4-dioxygenase-subunit-alpha
MSEELKFVQTPSQTIGPFFGFALPIERGEQLVPGHRAGAIRLHGTVTDGAGEPVIDAVVEAWQADETGAISTECGVLARDGYGFTGFGRTSTNLAGAYSFTTVKPGAVGRSAPYVLITIFARGLTRHLFTRAYFPEDVDAHAGDAVLSAAGGRAGTLVSVADGDGSYRFDIRLQGENETVYLDFDA
>NZ_CP017146.1|WP_161885279.1|838986_839754_+|protocatechuate-3,4-dioxygenase-subunit-beta
MTTQSEITAEIEAAEADAARRVAGGELPALQPRLDYPAYRSTGLRHPTHELMRADPEEIERVSPTFGHSDVNVLESDLTIQHAGEPIGERITVSGRVLDGEGRPVRGQLIEVWQANSAGRYVHKRDQHPAPLDPNFSGVGRAITGDDGGYRFTTIRPGPYPWLNHVNAWRPAHIHFSLFGTAFTQRLITQMYFPGDPLFALDPIYQSITDPAARARLLGHYTHDDSVPEFSLGYRWDIVLTGPRATWMEAEGSDV
>NZ_CP017146.1|WP_161885278.1|837785_838967_+|4-hydroxybenzoate-3-monooxygenase
MPHERTRVAIIGAGPSGLLLAWALRQSGIDSIVVENRSRDYVLGRIRAGVLEQGSVETLTRLGLGDRLAREGLVHDGIYLQWGGERQHIDFAELIGRTVTVYGQQEVVKDLMAAHDAAGSTVYYDSADVAVHGVETTSPRVTFTHEGEAHDITADFIVGADGFHGICRSAIPASELALYDRTYPYAWLGILADVAPSTDELIYALHEDGFAMHSMRSPHVSRLYLQVDPAEKIEAWSDERIWEALQVRLGVDGWNLTEGPITEKSITPMRSFVASRMDYKNLFLVGDAGHIVPPTGAKGLNSAITDVTLLAAGLIDHYAGDDTRLAGYGAASLGNQWRGQQFSQWMTELLHRDTTDLQSADFNYRSQRGRLDYVSRSAHAQRALAEQYTGLGF
>NZ_CP017146.1|WP_161885277.1|836890_837694_+|IclR-family-transcriptional-regulator
MSGKPARSGTPAGDDASRDDRSVAARVFAIVDAFTSPAAASLSLTAIARRTGLPLSTTHRLVAEWVQWGGLMRQEDGNYALGLRLWEVGVQTPTAHNLRTIALPYLEDLYEATREHVHLAILDGHDALNVEKLSGHQAVRVSSRVGGRLPLHSTGVGLVLLAHAPFEVIDAYLATSLRRFLPLTVTSPDELRKRLAAIRASGIAHASEEMTVGSSSIAAPIRDRTGAVVAAVSVVVTTTPKPDPAHESAVRAAARGISRTLGYRRSI
>NZ_CP017146.1|WP_161885276.1|835270_836740_+|MFS-transporter
MRFRKLAVVVLLFASFMDLLDTTIVNVALPSIEEDLGATSAQLEWIVSGYILSFAVLIITGGRLGDIFGRKRLFLIGVAGFTLASASCAAATGGEMLVVSRIVQGVFGAVMIPQVLSIIQVLFAPKERVGVFGALGAISGLAAVAGPLVGGILVTQNAFELGWRSVFIINVPVGIALFITAALCIPESRAAGRVRLDVPGVVFISAALFLLVYGLIEGRALGWPVGIWIMMGSSPVLLAVFVWYQNLRDKKSGSALVPPSLFHSRGYSAGVLTQFSFNASIGGFFLILVLYLQIGLGFSAIEAGLTTLPFSLGALLGSGIAVPLGPRLGKGLILLGALAQISGYWWITRIVEAQADALVGTDLIAPMALAGLGLTLLVVPLTDVALAQTAIANAGAASGVLGTFQQVGSAIGVAVVGVVFFGTVGEAYTPDVLRDAFLAGMWVPMSALALAALASLLLPNVKQVAAHKAAVEITQDDHEAPAREDAISL
>NZ_CP017146.1|WP_161885275.1|833274_835014_-|FAD-binding-protein
MPHDTVTGRRISTSVLVIGTGGSGLRAAIELSERGVDVLAVGKRPKNDAHTSLAAGGINAALATMDAEDSWQQHAADTIQESYFLANPHTAEIVTKNAGRGIQDLERWGMPFARERDGRISQRYFGAHKYRRTAFAGDYTGLEIQRTLVARAAQLEVPILDSVYITRILVRDNVVFGAYGFDLRDGSRVTIIADAVIIAAGGHNRIWRRTSSRRDENTGDSFKLAVDAGGRLRDAELVQFHPSGILEPENAAGTLISEAARGEGGVLRNALGERFMANYDPERMELSTRDRVALAAYTEIKEGRGTAKGGVLLDISHLPRETIMTRLPRVYQTMLELQVLDVTTTAIEIAPTAHYSMGGVWVRPDDHSTDVVGMYAIGEASSGLHGANRLGGNSLIELLVFGRIVGQAAAEYSAGIVSQNRSQDAIDAAAREVTGTLASDGQENVRALQRDIRNTMTDFGGVVRDEAGLLEGLRQLDELDDRQSRIGVHPDVAGFSGLAHAFDLRASLMAARATLACALERRESRGAHNRSDYPEMDPALQVNLVWSADGSIAHEQIPSVPAEIAALMEDVTQVGKLLE
>NZ_CP017146.1|WP_161885274.1|832000_833263_-|hypothetical-protein
MTLDATRAEGLARLADFVPRAGRAYAAERNLDRGPADRTNVSTLSPWVRHRLVTEADAVGAVLQRHSLDSASKFVQEVYWRTYWKGWLELRPSVWARYAAAVEPALTGLSAAQRASYDAAVTGHTGIEGFDDWARELVDTGYLHNHARMWFASIWIFTLRLPWQLGADFFLRHLLDGDPASNTLSWRWVGGLQTVGKTYLATTQNIEFATEGRFHPRGLATHAIALDDDAPAPTPLAAPQPEPLPTGRVALLLHEDDLNAESLASGLEAAGAQVVAVAAPSAGEPRSPLSLLSAEGFTAASVPEPSSPLAVEFTAGALADGRDRAGAHFATGTDALDAPTASAVLPWLRAHNVTALVTPYAPVGAVRDRLDRLASDLAAEGVTLTRVLRPWDAQAWPHATRGFFSFRERIPALLREQQIR
>NZ_CP017146.1|WP_161887334.1|831000_831894_-|SDR-family-oxidoreductase
MRDQYSFDNPVERYSRVEPPVQHQPEPGVQARMTPVPDLGESSYRGSGRLAGRKALITGGDSGIGGAVAIAFAREGADVVIVHLPAEQEDADRILGLIEEAGTTGHAIAADITDSARCREIVDETVRMLGGLDILVNNAGKQVAVARLEDLSDEQFELTFRTNIFANFWITKAALAHLPAGASIINTASLEAYKPAPDRLDYAATKAAVNNFSKGLAQQLAPRGIRVNVVAPGPVWTALQVSGGVSDEQMKAFDDESTYQRSGQPAELAPAFVFLASAESSYVSGETLNVNGGMVTP
>NZ_CP017146.1|WP_161885284.1|843239_844031_+|CoA-transferase-subunit-A
MDKTYPSAAAAVADIGSGASLAVGGFGLVGVPIVLIRALLAHGSSDLRVVSNNCGVDGWGLGELLSEGRISRVTASYIGENKDFARRYLGGELEVELTPQGTLAERMRAGGAGIPAFFTASGVGTMVADGGLPWRYGPAGEVTVQSPPKETRTLTSLGRELEYVLEEAIVTDFALVRAARGDRHGNLVFEKSARNFNPVAAMAGRVTIAEVDELVEPGEIDPDDVHLAGIYVNRIVQLSAEDAADLPIEKVTTRPRPQTTTEA
>NZ_CP017146.1|WP_161885285.1|844034_844715_+|CoA-transferase-subunit-B
MPLTRNEMAARAALELADGSYVNLGIGLPTLIPNYLAAGTSVILHSENGVLGVGPYPWEGEEDPKLINAGKETITVNRGAAYFDSAQSFGMIRGGVIDVAVLGAMQVSATGDIANWAVPGKMIKGMGGAMDLVHGADTVIVLMEHSTKTGEFKIVPECSLPLTGKRVVTRIITDLAVIDVTPVGLVLREIAPGLSVADVQAATGVPLVLEGEPVVIRTTDADGRAA
>NZ_CP017146.1|WP_161885286.1|844711_845941_+|acetyl-CoA-C-acetyltransferase
MSGPNTLREVVICEPLRTPVGRFGGMFKAVAPADLAATVIRALIERTGIDGAAVDDVILGQGYPTAEAASVARVAALNAGLPVTVGGMQLDRRCGSGLQAVLDAAMQIQTGVSDLAIAGGVDSMSQAPFYTVDSRFGVTGTGGIQLRDALARGRETAGGRNYPVPGGMLETAENLRREYSIGREEQDALALRSHQRAVRAVAEGRFDDEIVTVTVPGRKGDVVIDADETPRADSSLEVLAALRPILVKTDAEATVTAGNASGQNDAAAACIVTTPARAAELGLTPIVRLVGWARSGVEPSRMGIGPVPATARVLDRVGLTLRDMDLIELNEAFAAQVLAVSREWGFTEEDWERTNVNGSGISLGHPVGATGARILATGSRQLQRTGGRYLLETMCIGGGQGLAAVFERV
>NZ_CP017146.1|WP_161885287.1|846123_846528_+|cytochrome-c-oxidase-subunit-4
MKTVLYVVGVCFLVVDAAYLIWSLADDNFELVGLLTIGLSGVMCVMLAFYFGQVLRGDGANLAEDRLDAGIDDGDPEAGFFSPWSWWPVLLGGAISAVVLGLAISPWIAMFSLPLLVITIVGWQFEYFRGNFAH
>NZ_CP017146.1|WP_161885288.1|846550_846856_+|hypothetical-protein
MQLQLLIDRMIDQAHEVDPGGTYSILVGNAPATELEWVRGKKVYRWCQVVQTRVVPNYAVVLAPSPDNLRNSDLVEFHGRILDGDVTRHTIRRGVGTGHLA
>NZ_CP017146.1|WP_161885289.1|846870_847155_+|hypothetical-protein
MLRTVVPVPVPVPVPVPVPAASAELALVQPATVAERRDWLAANHADARGAWVAIGKKGNTVTALDYDGPSGRPCASAGSTAWPDRSTRAASCSE
>NZ_CP017146.1|WP_161887335.1|847486_847672_+|hypothetical-protein
MLLDKEQIIDFLRSLGRNDEATRADAELPDKVDTDKDRGLLEKFGVDPKEVLGQLGRSFGL
>NZ_CP017146.1|WP_161885290.1|847709_848210_+|metallophosphoesterase
MTRLLLLADTHVPTRARALSAQVWSAIESADLVIHAGDWIETGLLDQMEARAARLVGVWGNNDPPELRERLPEIARVEVDGIRIAVVHETGPARGREARSDELFADADVLVFGHSHIPWDSVTPGGLRLLNPGSPTDRRRMPTCTYLTAVAEAGVLRDVRVVDTER
>NZ_CP017146.1|WP_161885291.1|848520_848922_+|YchJ-family-protein
MTDSEWRLAATARCPCLSGLQYGECCGPFHHGSAFAPTAERLMRSRYSAFAVGDADYLLATWHSTTVPSRLELDPEQRWYRLEIEATSRGGMLDTEGTVEFRAFSRADGSASEQHEVSRFVREKRRWVYLDGV
>NZ_CP017146.1|WP_161885292.1|849287_850679_+|protein-kinase
MGERSGDEVRGLLHGRYRLLKLLGEGGMARVFQAHDEFLGRDVAVKVFRSNAVAESDLRRQKDEINVLAGLGHHSLVTLLDAAVDKSVPGEPRIFFVMELVEGIDLRERIEKGGPVSPRHIAHIARDLAEGLEFVHNRGIVHRDIKPANILIVDYDDNATTARARLTDFGIALRAESTHISAENAVTGSVAYISPEQALGEPLGAPTDIYSLGLVLLECFTGTIEFPGPAVQSAVARLIRRPNVDPVLSPEWREILAAMTSRDPVDRPDAGELVKAFRQMITAESGRHAGPMDAPNEAGRMDAVLRYDLLDTPPDGSFDRITAVAARVFGVPFAIVSVVDTDRVWFKSRHGVDAEQIGRDPGLCASAILHDEPWIIEDARADPRALANPLVAGEFGMQFYAGVPLTTRDGFSLGTLCVMDLEPRTVTADEIATLQDLAAMVMRELNLRWETRRAAAELASAAL

Crispr_ID: NZ_CP017146_7

• CRISPR_ID: NZ_CP017146_7
• CRISPR_location: 866072-866228
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP017146_7

Consensus_repeat	Method
CGGTGACCGTTGACGAGCACCCGGTGACCGT	CRISPRCasFinder

spacers of NZ_CP017146_7

>7.1|866103|32|NZ_CP017146|CRISPRCasFinder
GCGCCAGCGGTCGCTGACCGTCGACGAGCACT
>7.2|866166|32|NZ_CP017146|CRISPRCasFinder
CGACGGGCACACGGTGACCTTGGAGGGGCACC

CRISPR arrays and Neighbor proteins around NZ_CP017146_7

CRISPR arrays

The CRISPR arrays of NZ_CP017146_7

>merge|NZ_CP017146|7|866072-866228|CRISPRCasFinder
CGATGACCGTGCGCGAGCAGCCGAGGACCGTGCGCCAGCGGTCGCTGACCGTCGACGAGCACTCGGTGACCGTTGACGAGCACCCGGTGACCGTCGACGGGCACACGGTGACCTTGGAGGGGCACCCGCTGACCGTCGACGGGCACACGGTGACCGT

>NZ_CP017146|7|6|866072-866228|CRISPRCasFinder
CGATGACCGTGCGCGAGCAGCCGAGGACCGT	GCGCCAGCGGTCGCTGACCGTCGACGAGCACT
CGGTGACCGTTGACGAGCACCCGGTGACCGT	CGACGGGCACACGGTGACCTTGGAGGGGCACC
CGCTGACCGTCGACGGGCACACGGTGACCGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017146.1|WP_161885306.1|866735_867602_+|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187578
NZ_CP017146.1|WP_161885296.1|853801_855463_-|DUF222-domain-containing-protein	unknown	unknown	gnl|CDD|367155
NZ_CP017146.1|WP_161885303.1|863524_865042_-|DUF3375-domain-containing-protein	unknown	unknown	gnl|CDD|371764
NZ_CP017146.1|WP_161885313.1|873366_873579_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161885302.1|862736_863528_-|DUF4194-domain-containing-protein	unknown	unknown	gnl|CDD|372745
NZ_CP017146.1|WP_161885309.1|869916_870174_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|238045
NZ_CP017146.1|WP_161885297.1|855727_856267_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161887336.1|857587_857941_-|HNH-endonuclease	unknown	unknown	gnl|CDD|372995
NZ_CP017146.1|WP_161885300.1|858239_859391_-|hypothetical-protein	unknown	unknown	gnl|CDD|227261
NZ_CP017146.1|WP_161887337.1|875303_875624_+|nucleotide-pyrophosphohydrolase	unknown	unknown	gnl|CDD|212144
NZ_CP017146.1|WP_161885311.1|871428_872682_-|NYN-domain-containing-protein	unknown	unknown	gnl|CDD|350237
NZ_CP017146.1|WP_161885307.1|867999_868998_-|acetamidase	unknown	unknown	gnl|CDD|225279
NZ_CP017146.1|WP_161885299.1|858089_858236_+|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl|CDD|350308
NZ_CP017146.1|WP_161885310.1|870166_871402_+|type-II-toxin-antitoxin-system-HipA-family-toxin	unknown	unknown	gnl|CDD|341493
NZ_CP017146.1|WP_161885301.1|859374_862740_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|227250
NZ_CP017146.1|WP_161885314.1|873784_875146_+|hypothetical-protein	unknown	unknown	gnl|CDD|226205
NZ_CP017146.1|WP_161885295.1|853000_853402_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161885308.1|869011_869773_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|183775
NZ_CP017146.1|WP_161885298.1|856733_857591_-|DUF429-domain-containing-protein	unknown	unknown	gnl|CDD|226778
NZ_CP017146.1|WP_161885312.1|872789_873311_-|DUF2510-domain-containing-protein	unknown	unknown	gnl|CDD|378480

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP017146.1|WP_161885306.1|866735_867602_+|SDR-family-oxidoreductase	gnl|CDD|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	9.80888e-72
NZ_CP017146.1|WP_161885296.1|853801_855463_-|DUF222-domain-containing-protein	gnl|CDD|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	1.01214e-14
NZ_CP017146.1|WP_161885303.1|863524_865042_-|DUF3375-domain-containing-protein	gnl|CDD|371764	pfam11855, DUF3375, Protein of unknown function (DUF3375). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 479 to 499 amino acids in length.	1.1649e-111
NZ_CP017146.1|WP_161885302.1|862736_863528_-|DUF4194-domain-containing-protein	gnl|CDD|372745	pfam13835, DUF4194, Domain of unknown function (DUF4194).	2.41053e-34
NZ_CP017146.1|WP_161885309.1|869916_870174_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.45139e-06
NZ_CP017146.1|WP_161887336.1|857587_857941_-|HNH-endonuclease	gnl|CDD|372995	pfam14279, HNH_5, HNH endonuclease. This domain is related to other HNH domain families such as pfam01844. Suggesting that these proteins have a nucleic acid cleaving function.	1.17025e-07
NZ_CP017146.1|WP_161885300.1|858239_859391_-|hypothetical-protein	gnl|CDD|227261	COG4924, COG4924, Uncharacterized protein conserved in bacteria [Function unknown].	3.1729e-49
NZ_CP017146.1|WP_161887337.1|875303_875624_+|nucleotide-pyrophosphohydrolase	gnl|CDD|212144	cd11537, NTP-PPase_RS21-C6_like, Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs. RS21-C6 proteins, highly expressed in all vertebrate genomes and green plants, act as house-cleaning enzymes, removing 5-methyl dCTP (m5dCTP) in order to prevent gene silencing. They show significant sequence similarity to the dimeric 2-deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTP pyrophosphatase or dUTPase) and NTP-PPase MazG proteins. However, unlike typical tandem-domain MazG proteins, RS21-C6 contains a single MazG-like domain and functions as a tetramer (a dimer of dimers) with a typical four-helical bundle. Divalent ions, such as Mg2+, are required for its pyrophosphatase activity. This family also includes a pyrophosphatase from Archaeoglobus fulgidus (Af1178). Although its biological role remains unclear, Af1178 shows significant sequence similarity to the mouse RS21-C6 protein.	2.24778e-35
NZ_CP017146.1|WP_161885311.1|871428_872682_-|NYN-domain-containing-protein	gnl|CDD|350237	cd11297, PIN_LabA-like_N_1, uncharacterized subfamily of N-terminal LabA-like PIN domains. This N-terminal LabA-like PIN domain is found in a well conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. LabA from Synechococcus elongatus PCC 7942, (which does not contain this C-terminal domain), has been shown to play a role in cyanobacterial circadian timing. The LabA-like C-terminal domains characteristic of this subfamily may be related to the LOTUS domain family (which also co-occurs with LabA-like N-terminal domains). The function of the N-terminal domain is unknown. The LabA-like PIN domain family also includes the N-terminal domain of limkain b1, a human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes. Other members are the LabA-like PIN domains of human ZNF451, uncharacterized Bacillus subtilis YqxD and Escherichia coli YaiI. Curiously, a gene labeled NicB from Pseudomonas putida S16, which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like PIN family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	2.64172e-32
NZ_CP017146.1|WP_161885307.1|867999_868998_-|acetamidase	gnl|CDD|225279	COG2421, COG2421, Predicted acetamidase/formamidase [Energy production and conversion].	4.8635e-61
NZ_CP017146.1|WP_161885299.1|858089_858236_+|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl|CDD|350308	cd18741, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	0.000971842
NZ_CP017146.1|WP_161885310.1|870166_871402_+|type-II-toxin-antitoxin-system-HipA-family-toxin	gnl|CDD|341493	cd17808, HipA_Ec_like, type II toxin-antitoxin sytem toxin HipA from Escherichia coli and similar proteins. This family contains type II toxin-antitoxin (TA) system HipA family toxins similar to Escherichia coli HipA, a serine/threonine-protein kinase that phosphorylates Glu-tRNA-ligase (GltX), preventing it from being charged, leading to an increase in uncharged tRNA(Glu). This induces amino acid starvation and the stringent response via RelA/SpoT and increased (p)ppGpp levels, which inhibits replication, transcription, translation and cell wall synthesis, reducing growth and leading to persistence and multidrug resistance. HipA is the toxin component of the HipA-HipB TA module that is a major factor in persistence and bioflim formation; its toxic effect is neutralized by its cognate antitoxin HipB. HipA, with HipB, acts as a a corepressor for transcription of the hipBA promoter. In the Escherichia coli HipAB:DNA promoter complex, HipA forms a dimer and each HipA monomer interacts with a HipB homodimer which binds DNA. The HipAB component of the complex is composed of two HipA and four HipB subunits.	1.42336e-69
NZ_CP017146.1|WP_161885301.1|859374_862740_-|AAA-family-ATPase	gnl|CDD|227250	COG4913, COG4913, Uncharacterized protein conserved in bacteria [Function unknown].	6.75347e-179
NZ_CP017146.1|WP_161885314.1|873784_875146_+|hypothetical-protein	gnl|CDD|226205	COG3680, COG3680, Uncharacterized protein conserved in bacteria [Function unknown].	1.64771e-06
NZ_CP017146.1|WP_161885308.1|869011_869773_-|SDR-family-oxidoreductase	gnl|CDD|183775	PRK12826, PRK12826, SDR family oxidoreductase.	9.07588e-51
NZ_CP017146.1|WP_161885298.1|856733_857591_-|DUF429-domain-containing-protein	gnl|CDD|226778	COG4328, COG4328, Predicted nuclease (RNAse H fold) [General function prediction only].	1.19874e-12
NZ_CP017146.1|WP_161885312.1|872789_873311_-|DUF2510-domain-containing-protein	gnl|CDD|378480	pfam10708, DUF2510, Protein of unknown function (DUF2510). This is family of proteins conserved in Actinobacteria. Many members are annotated as putative membrane proteins but this could not be confirmed.	1.77907e-05

Protein sequences

>NZ_CP017146.1|WP_161885303.1|863524_865042_-|DUF3375-domain-containing-protein
MVTRSDAALVQSAARFDRVRRDSAWSLLRANQAPIVLAVLHANFVESGEARVPATVLFERIGDDLEALRVAGHELPQSPQRYVADWLDAGYLERRTGSAGTSGAGSGAGSSAAETYELSADALAALRIATEIVTPPRSVTESRLTTVMGQLEQLAIDTDTDVASRLESLTRERERLDHRISNIREGRIDVVAPDAALERIRDILLLAEQLPADFARVRRDVESLNVQFRRDIIESDGARGEVLDALFRGVDVLQDNEAGRSFGAFYALLINPERSAGLDRSIDDVLTRDALGSLKPAERIALRTLVERLTSRGGEVHEVYASLARSLRTFVQQREYVEERRVSRLLKQAQRAFGELSGDGSLIRPTGFTLSLSKAQLGSVSQFTMTAPDTERPPGLVDNPPVELDLDRVRELINESDINLYELRRNVDATLEDLPVASISDVLDRYPATQGLGSLIGLLSIGLERTVNGRAVLVENERDLVAWGDSGLAARVPTILFTQSSEEHP
>NZ_CP017146.1|WP_161885302.1|862736_863528_-|DUF4194-domain-containing-protein
MTPARTAQQKPQSADAQSAEAPGDDESAASATLFVGDTGTLDLDTRLALVKLLRGPFLDGSREPARWAALRRSEVSVRRYLSEIFLLLVIDEVERIAFTQQASESDAVIPSVLRQVPLTMIDSALVLFLRGQLSAVAGTGQRAIVGYDDIVAQLTPYRREGTTDESAHLKRMNGAVRKMIDAGVLANTSTEGRYEISPVLRILFPAEQIAALTDAYEALRGADATDARLDLPDEAPDEHQSAEHQSTETRNDDTDTASAEETA
>NZ_CP017146.1|WP_161885301.1|859374_862740_-|AAA-family-ATPase
MSDDTLFDDLDGALRSSRGQHRLTGIQLVNWGTFANHHRIDVAEKGFLITGASGSGKSTILDAISVVLVRPKDLNLNAAAGDAGQRVRDRTVLSYLRGSWSINADEITGEVATQQLRPGTTWSAVALEYSDGKGIETTLVRVFWAARGVTDPGGVKSVNLIADRRFDLHDLEPVLADGLSLRTVKALLSPWYAGDQYPAFQEKFARRLGIGGERALRLLHKTQATKGLTSLDSLLRDFMLDEPETFAIASRMVEQFDELSAAHEAVQTARKQVAHLEPVRGLDAELGTLSTRAAGLEDETAATEWYVTERAIVLHHDEIARTQRDRTDAAAEGSALEADLSLITGRIDVLREQHLTAGGGRLDGIRSERDQATGELSSRTRRQGALRSHLSVLGAAIPSTQGDHAELVNQAQTEIDTLAAGGAEVDREQYDAFAGADDAKRKLAAVRAEMATLATSRSNIDSADLRLRDELATAARVDPKRLPFVAELLDVPEEHAEWRGAIERLLGGFARSVLIPESVYAAASAYIDSTHLGRKLLYYRVPRELTNKPRAIGPDSVVHRIEVADSPTAEWLHAELSGRFDYACAESLAAFQRAEKAITRNGQVRHGSSRHEKNDRSRIDDQRQWVLGFDNAAKQQLFAADAERLQAELGAAEKQVDAVLGRRTAAQARLAACRRIVETPWDDIDTASAARHLHGLETLIAEFASTHRDLAQLDEQIAEQRSAAAAVEKALREAGARVHAASTALSRLERGLEERQSTRAELQGADAAALARLESRFTARSRSLTLERLGDLRAEVQKEISSEATAVERSIRSIRERLTQLFTEFKAEWTAEAADVDTDVEATGEYLRILERIEHDGLPQFETKFLTMLQHLSTMSLGQLRRQIDQERRQIRDRITPINESLALSEYGHGTILRIDVKERQLALVNDFKKDVAAATDESLVNDPARATERFEILRRLVTRFGSPEPEHRHWREQVLDVRRHVEFEAREIGEGGETVEIHTSGAGRSGGQRVKLVTFALAAALRYQLGGRNAERPDYGTVVIDEAFDKADADFTEKSMRIFEQFGFQMVLATPMKLIQTLSPFIGGATVIHIRDRKASSAFPIDLVELTATSAQQRADALDR
>NZ_CP017146.1|WP_161885300.1|858239_859391_-|hypothetical-protein
MRSIAEARVEARRIFDRNLGGWAWSAVQGEPAERIPLALNLQPPTGDEALDRVAEMREWSSAWHDFAGAGEVEFATRRFRYLGTQSVPVRLHLEQPAEVAAFIASTAHWRALVARLGELVAQWPDMSRPDAAAVRRVLDVPTSSWSHVVGFLRWSADLDLSELLPRQIAFPGVDSKWFDQNRPLLVALRAAGAGTRRLTTRQIDSRMLVRVLDPALRAEVGGLAEFAAPATELARLVWAPGEVIISENLQSAYSFGDRPGCVVLAAQGYAVEAYGGLPWLQRAHVRYWGDLDTHGFAILNRLRHHLPRVDSVLMDADTLLAHRSLWAREEKPQSAQLPLLTASEREAYEVLLSEPNARLEQERLPWGVVEAAFGVSVAGRELR
>NZ_CP017146.1|WP_161885299.1|858089_858236_+|type-II-toxin-antitoxin-system-VapC-family-toxin
MLDHERADAAELTSLIEWVPVVEPISIRAGELGRRWMSSHSGIGAAPE
>NZ_CP017146.1|WP_161887336.1|857587_857941_-|HNH-endonuclease
MALVEHDLTPEQWGMLQHLWGGCAYCGAGDRALQRDCVQPISRGGRYTLDNIVPACGACNASKSNDEVTSWMRRKKLDERRFLVRFVEVRDALMPDDTDIETGHMNAGLGGTHGSAP
>NZ_CP017146.1|WP_161885298.1|856733_857591_-|DUF429-domain-containing-protein
MTHYLGIDLAWGEGTATRPAKETGVALIDETGTVLHAGWARGIDPVAEWIVEVAPPGAVIAIDAPLVVENQAGMRLCERQVGMGYGRWHVAANASNTALGWQGGVALRKKLEARGFVYTDGIRPPGPLERTMFECYPYTTIVGMAELGYEEKRPRYKRFDMALPSALRRQARADACDELIRRMAALGTATPPLHIASHEVSRSLLEPSPLVDAAYKHREDMLDAVLCAWTAAIWHRHRERVQVLGADDVPDAAGRRGTIVAPARDGQRVAGRAMRVLREGSSPSP
>NZ_CP017146.1|WP_161885297.1|855727_856267_-|hypothetical-protein
MIIEAGFDLVQLLHPEVLADAVSRRALWMLAADKDLRLLEISPVCPEFSGSLEPHVADIVAALAGSYRPVRYFALAHTTSPLDCDDWERISWDDQVLCEAHDFEPDQFLGRLVFDGDHIYSSAPRYSFRDYVGRENLPRAAVISGPHFGDCSCVACAQFNEMMAEYRALREAAEHGPAD
>NZ_CP017146.1|WP_161885296.1|853801_855463_-|DUF222-domain-containing-protein
MDEPSLSPPQTLPESLSEPLTQSPSESLVEPLTRSPLDPPSESLSSSLRESAARVASLGDHSCALRCLTSADLLAAQSAITTLRRCVDRYAAMAAGEIAHRSTPEHGHSGLAQKAGFVSPEAMLQSIANISRIEAVKLMRVGSFIAESEAAAELAASAASLDDTDGAGVEPGTGGPDAGLDGTGDGTGDGNAHGHVSFLPQFPPPPPWQAPLAAALAAGILSIDAVESIRRALGDVDPAITAGALTAACEHLIGTSTGLTPEQLYRKARQLRDSLDEAGIERREKERRDLRSVRTWWDPAGMYCGSFRLPPEEGMIVSTAFDEILSPRRGGPRFVDLEAKASAEELLNDQRSTEQIAADGLVDLIRLAVDADPGTMFGRRRPAVRVMVTDQHLHVMAGHGRLEGHPDPVSFATVERHLCDTGTIAVGFDNDGQCVNVGRNQRFFTERQRIGMTLRDGGCMFAGCDRPPSYCEAHHIDEWLRDDGKTDIADGILLCRRHHLLLHNNGWQVIRVRADYYIRPPADVDPNRELIPLPSRNPEMRALKRQSDQRRAQ
>NZ_CP017146.1|WP_161885295.1|853000_853402_-|hypothetical-protein
MKKSLFAAGLAVAFVLVPTAAQALDCVNVSKPPASCGSNCTEGPIIHGNWAWLPSVFPGSPEVWAFVPPGTVEGFGLPGEKGNYQNGEGYALLVNAICDSTAGVLEHRQTGHGIQLLEGCQWAEIEADTGTPP
>NZ_CP017146.1|WP_161885306.1|866735_867602_+|SDR-family-oxidoreductase
MSAPGGAVLVTGSTGNVGRAVARHLALAGETVVSGVRDESSGGGAVRDTEARVLDFENPAGWPAALAGVDRMFLLRPPQISDVRRVLFPLIDRALDAGVRQIVFLSLQGVQFNAATPHHAVEKYLRERSAPFTFLRPNFFMQNLSTTYRDDIRDRGEIFVPAARARTAFVDTDDLGAVAAAVLTRPGHVGKAYTLSGEQSLDYYGVARQLTAALGYEVRYAAPSVEEYVARLTEQGAAADYIEVQKMIYRVVRMNVSAFPNRTIRRLTGRPATTFAQFAERERAAWAR
>NZ_CP017146.1|WP_161885307.1|867999_868998_-|acetamidase
MNIVEFTPERSQYVYTFGGAEPVMRVNPGTALALWSEDAYNHALRSVDDLASAKLDVRYLNPQTGPFYIVGAEAGDTLAVHIVSLTPARSWGASATIPFFGGLTSTDRTAMLQPALPEATWIYEVDTDAGTVGFQSRFGDFEVALPLAPMLGTVGVAPAGSEVRSSLVPERFGGNMDTPEMKAGTTAYLGVNVEGALLSIGDGHYRQGEGEACGTAVEGAMNSVIIVELIKGGGPLWPRLENDDYWMVVGSSRPMEDSWRIAQLEMTRWMAEMFDLHEMDAYQLLSQITETPIANVVDTNYSVVVKVPKKYFTRVQAFDGMHRELRGRARRV
>NZ_CP017146.1|WP_161885308.1|869011_869773_-|SDR-family-oxidoreductase
MDLNLTGKTALVTGGTKGIGRAIVDAFVSEGANVAFCARDADEVAAVEAAYADATPTVLGSVLNVRDAAALTAWVDDTAVRLGGIDMIVANVSALAIPDTAENWVESFEVDLMGTVNLVKASLPYLENSPAPSIVAISSVSGREADFASGPYGTAKSAIIGYISGLALQLADKGIRANVVSPGNTYEPGGVWAGIETGNPDLFSLAMGLNPTGRMGTPQEIADSVVFISSPRSSRTSGTNLVVDGALTRGMQF
>NZ_CP017146.1|WP_161885309.1|869916_870174_+|helix-turn-helix-transcriptional-regulator
MAARGEVRSPDALGRMLQQGRLVSGLTQRELADRLDTDQKYVWALESGKNTIVLERIFAMMRETGIRMYLEIEPPTSDSPDEPRG
>NZ_CP017146.1|WP_161885310.1|870166_871402_+|type-II-toxin-antitoxin-system-HipA-family-toxin
MADLRVELCGELVGRLVGTDRRSFDFVADPQAIETFGLGSTMLSESVPFELVANRSRGARRRNFFAELLPEGMALDSLAAELRVSTDDIIPLLAQYGRDVAGAVQIYDPEAPGEPCTPELAPVDADEVGRMLANTQSAPLGNHPQSGRTSLAGVQDKIVLARQGSQWFQVLDGYPSSHIIKSPSTRHPTITFDEEYGFRAAKAAGLTTFDSWIEDFGDVRGLVIERYDRSRESPDGRIHQEDMNQALGAAKNEKYQEFGGKVSLRRIAGVLGRNGDRRSVDQLLRLVTVSQALGNLDLHGKNISMLHLRDGSTRIAPAYDVVPQTHLDSGGRMALAINGKYAHATIAMDDLVAEGESWKVRSPRPLVAEALEAVEAFVAAENPDAGSYSGLREDIARFTANLLGGRPTGSR
>NZ_CP017146.1|WP_161885311.1|871428_872682_-|NYN-domain-containing-protein
MDDPVGRRDIAVFIDMENLFGGYGADVSGVPLSRILNEIHAEVKSLEVGSLAATTRAYANWGFKGMTTYHREVLENGVEPVHIFSNDGRASANHDGRRKNAADIQLVVDALTVAVEAPWVKVFVIVSGDGDFVPLVRRLQYLGKVVIGVGLSDGRAGGVSKLLRTVVDHFLEVRVGEDLLSPVPPVARAKADATATKPAAAALSSVPSDRIPSLKEYVATVVQLTKSHPNALKSGAVDGAVMGGLLRRRWPRVTYSDFDYRTLGSFIEDACKLPMFRPNVANASPTATPQPTTVTPPSLRAELEAVPPRISYPEIGPLTKVLTELTLQFEPLPFDDLSDRVGGELSDVPAEQIRLALRLLLSVGAFSEVGMDGLNLSGDVASVEDGISLVLDDAQRRARTIDRSVTKAEVEAALFPE
>NZ_CP017146.1|WP_161885312.1|872789_873311_-|DUF2510-domain-containing-protein
MTTPVSGWYQDPADPSDPEQFRWWNGIAWSEETRRRVPSPVVPTPAPAPLQAPLPNTALYEPDARAYLPMAGYTPREIHVETAPPAPLSRKEKDRELRQHNPMAYTGLLLSLVGMLFNPLALLSILGLVFSAVGLAASYRLESLGARTTGRGTAGVGIALGVIGVALFLWLIL
>NZ_CP017146.1|WP_161885313.1|873366_873579_-|hypothetical-protein
MNPDDIIGIAGYGGLAILFWIVLVVGGFILSAWIMSLYVRLILKFSRRALDREYRYMRGDYYVPARTNRQ
>NZ_CP017146.1|WP_161885314.1|873784_875146_+|hypothetical-protein
MMMTEAIDIPAIDEPTLIVVINRAWRPGLTADQVYEATRGHWRVGRTSREAVSLVIGVADHEVRGVYRPESWFSSPLIGEEGRWGFEGVPANDLQAILGTSVDRLRRANGAANPVRLFLDGIPGVDVLEAAGYTWELDPGDFLGRHERGQVYGGALYGGIEMSSVTPNVFVYSDPRAGLINGYDFDGWNEDRTLFYYTGEGRAGSQTMREGNKAILDHSADGRALRLFVAEGFEPKSKTARQRYLGEFKVDELRPFDVEEALDSNGELRSVFVFRLRPVGDVLARSREDSQDPIAAETSVENYELNGQGLEQLVEQIEVEMLRTPSSMHLMSERLTIVVRREAAMVLALRDFLGTNGQRIVRHRIRPQGQAFSLMTDAYDASGGILYEAKSDATRQSVRMAIGQMLDYQRFMPAGTRLALLVPVLPALDLQDLCRSLGIGICVPNGKKFETYW
>NZ_CP017146.1|WP_161887337.1|875303_875624_+|nucleotide-pyrophosphohydrolase
MTARSVRDELAAFVAERDWGQFHTPENLAKSIAIEAGELLECFQWSPDADTDRVRGELADVLTYCILLAERIGADPDQLVLEKLAVTRAKYPADKARGRSAKYDAL

Crispr_ID: NZ_CP017146_8

• CRISPR_ID: NZ_CP017146_8
• CRISPR_location: 986672-986748
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP017146_8

Consensus_repeat	Method
CCCGACGCGGCCTGTGCTGCGCGG	CRISPRCasFinder

spacers of NZ_CP017146_8

>8.1|986696|29|NZ_CP017146|CRISPRCasFinder
GAGTAACGCGCTTGCGCGGGCTGCGGATG

CRISPR arrays and Neighbor proteins around NZ_CP017146_8

CRISPR arrays

The CRISPR arrays of NZ_CP017146_8

>merge|NZ_CP017146|8|986672-986748|CRISPRCasFinder
CCCGACGCGGCCTGTGCTGCGCGGGAGTAACGCGCTTGCGCGGGCTGCGGATGCCCGACGCGGCCGGTGCTGCGCGG

>NZ_CP017146|8|7|986672-986748|CRISPRCasFinder
CCCGACGCGGCCTGTGCTGCGCGG	GAGTAACGCGCTTGCGCGGGCTGCGGATG
CCCGACGCGGCCGGTGCTGCGCGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017146.1|WP_161885397.1|984275_985244_+|DNA-topoisomerase-IB	unknown	unknown	gnl|CDD|226099
NZ_CP017146.1|WP_161885394.1|978230_979805_+|histidine-ammonia-lyase	unknown	unknown	gnl|CDD|236484
NZ_CP017146.1|WP_161885405.1|991047_991839_+|30S-ribosomal-protein-S3	unknown	unknown	gnl|CDD|234722
NZ_CP017146.1|WP_161885406.1|991838_992258_+|50S-ribosomal-protein-L16	unknown	unknown	gnl|CDD|236411
NZ_CP017146.1|WP_161885392.1|975730_976924_+|elongation-factor-Tu	unknown	unknown	gnl|CDD|234596
NZ_CP017146.1|WP_161885398.1|985347_986325_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161885401.1|989166_989466_+|50S-ribosomal-protein-L23	unknown	unknown	gnl|CDD|235586
NZ_CP017146.1|WP_147783478.1|987465_987774_+|30S-ribosomal-protein-S10	unknown	unknown	gnl|CDD|179076
NZ_CP017146.1|WP_161885393.1|977383_978151_-|IclR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224332
NZ_CP017146.1|WP_161885403.1|990334_990616_+|30S-ribosomal-protein-S19	unknown	unknown	gnl|CDD|178985
NZ_CP017146.1|WP_161885396.1|981670_982555_+|formimidoylglutamase	unknown	unknown	gnl|CDD|212516
NZ_CP017146.1|WP_161885400.1|988438_989170_+|50S-ribosomal-protein-L4	unknown	unknown	gnl|CDD|235404
NZ_CP017146.1|WP_161885390.1|972834_973305_+|30S-ribosomal-protein-S7	unknown	unknown	gnl|CDD|235398
NZ_CP017146.1|WP_161887346.1|982806_984066_+|imidazolonepropionase	unknown	unknown	gnl|CDD|237604
NZ_CP017146.1|WP_161885399.1|987784_988435_+|50S-ribosomal-protein-L3	unknown	unknown	gnl|CDD|234564
NZ_CP017146.1|WP_161885404.1|990643_991048_+|50S-ribosomal-protein-L22	unknown	unknown	gnl|CDD|234793
NZ_CP017146.1|WP_161885407.1|992257_992602_+|50S-ribosomal-protein-L29	unknown	unknown	gnl|CDD|178971
NZ_CP017146.1|WP_161885402.1|989482_990322_+|50S-ribosomal-protein-L2	unknown	unknown	gnl|CDD|236488
NZ_CP017146.1|WP_161885391.1|973431_975549_+|elongation-factor-G	unknown	unknown	gnl|CDD|234569
NZ_CP017146.1|WP_161885395.1|979929_981585_+|urocanate-hydratase	unknown	unknown	gnl|CDD|235448

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP017146.1|WP_161885397.1|984275_985244_+|DNA-topoisomerase-IB	gnl|CDD|226099	COG3569, COG3569, Topoisomerase IB [DNA replication, recombination, and repair].	1.43994e-74
NZ_CP017146.1|WP_161885394.1|978230_979805_+|histidine-ammonia-lyase	gnl|CDD|236484	PRK09367, PRK09367, histidine ammonia-lyase; Provisional.	0
NZ_CP017146.1|WP_161885405.1|991047_991839_+|30S-ribosomal-protein-S3	gnl|CDD|234722	PRK00310, rpsC, 30S ribosomal protein S3; Reviewed.	1.26633e-139
NZ_CP017146.1|WP_161885406.1|991838_992258_+|50S-ribosomal-protein-L16	gnl|CDD|236411	PRK09203, rplP, 50S ribosomal protein L16; Reviewed.	1.10342e-91
NZ_CP017146.1|WP_161885392.1|975730_976924_+|elongation-factor-Tu	gnl|CDD|234596	PRK00049, PRK00049, elongation factor Tu; Reviewed.	0
NZ_CP017146.1|WP_161885401.1|989166_989466_+|50S-ribosomal-protein-L23	gnl|CDD|235586	PRK05738, rplW, 50S ribosomal protein L23; Reviewed.	1.08684e-39
NZ_CP017146.1|WP_147783478.1|987465_987774_+|30S-ribosomal-protein-S10	gnl|CDD|179076	PRK00596, rpsJ, 30S ribosomal protein S10; Reviewed.	6.66716e-62
NZ_CP017146.1|WP_161885393.1|977383_978151_-|IclR-family-transcriptional-regulator	gnl|CDD|224332	COG1414, IclR, Transcriptional regulator [Transcription].	4.31474e-42
NZ_CP017146.1|WP_161885403.1|990334_990616_+|30S-ribosomal-protein-S19	gnl|CDD|178985	PRK00357, rpsS, 30S ribosomal protein S19; Reviewed.	5.6764e-62
NZ_CP017146.1|WP_161885396.1|981670_982555_+|formimidoylglutamase	gnl|CDD|212516	cd09990, Agmatinase-like, Agmatinase-like family. Agmatinase subfamily currently includes metalloenzymes such as agmatinase, guanidinobutyrase, guanidopropionase, formimidoylglutamase and proclavaminate amidinohydrolase. Agmatinase (agmatine ureohydrolase; SpeB; EC=3.5.3.11) is the key enzyme in the synthesis of polyamine putrescine; it catalyzes hydrolysis of agmatine to yield putrescine and urea. This enzyme has been found in bacteria, archaea and eukaryotes, requiring divalent Mn and sometimes Zn, Co or Ca for activity. In mammals, the highest level of agmatinase mRNA was found in liver and kidney. However, catabolism of agmatine via agmatinase apparently is a not major path; it is mostly catabolized via diamine oxidase. Agmatinase has been shown to be down-regulated in tumor renal cells. Guanidinobutyrase (Gbh, EC=3.5.3.7) catalyzes hydrolysis of 4-guanidinobutanoate to yield 4-aminobutanoate and urea in arginine degradation pathway. Activity has been shown for purified enzyme from Arthrobacter sp. KUJ 8602. Additionally, guanidinobutyrase is able to hydrolyze D-arginine, 3-guanidinopropionate, 5-guanidinovaleriate and L-arginine with much less affinity, having divalent Zn ions for catalysis. Proclavaminate amidinohydrolase (Pah, EC 3.5.3.22) hydrolyzes amidinoproclavaminate to yield proclavaminate and urea in clavulanic acid biosynthesis. Activity has been shown for purified enzyme from Streptomyces clavuligerus. Clavulanic acid is the effective inhibitor of beta-lactamases. This acid is used in combination with the penicillin amoxicillin to prevent antibiotic's beta-lactam rings from hydrolysis, thus keeping the antibiotics biologically active.	4.3584e-62
NZ_CP017146.1|WP_161885400.1|988438_989170_+|50S-ribosomal-protein-L4	gnl|CDD|235404	PRK05319, rplD, 50S ribosomal protein L4; Provisional.	6.33906e-103
NZ_CP017146.1|WP_161885390.1|972834_973305_+|30S-ribosomal-protein-S7	gnl|CDD|235398	PRK05302, PRK05302, 30S ribosomal protein S7; Validated.	1.19306e-99
NZ_CP017146.1|WP_161887346.1|982806_984066_+|imidazolonepropionase	gnl|CDD|237604	PRK14085, PRK14085, imidazolonepropionase; Provisional.	0
NZ_CP017146.1|WP_161885399.1|987784_988435_+|50S-ribosomal-protein-L3	gnl|CDD|234564	PRK00001, rplC, 50S ribosomal protein L3; Validated.	1.6403e-124
NZ_CP017146.1|WP_161885404.1|990643_991048_+|50S-ribosomal-protein-L22	gnl|CDD|234793	PRK00565, rplV, 50S ribosomal protein L22; Reviewed.	1.5482e-53
NZ_CP017146.1|WP_161885407.1|992257_992602_+|50S-ribosomal-protein-L29	gnl|CDD|178971	PRK00306, PRK00306, 50S ribosomal protein L29; Reviewed.	1.55088e-18
NZ_CP017146.1|WP_161885402.1|989482_990322_+|50S-ribosomal-protein-L2	gnl|CDD|236488	PRK09374, rplB, 50S ribosomal protein L2; Validated.	0
NZ_CP017146.1|WP_161885391.1|973431_975549_+|elongation-factor-G	gnl|CDD|234569	PRK00007, PRK00007, elongation factor G; Reviewed.	0
NZ_CP017146.1|WP_161885395.1|979929_981585_+|urocanate-hydratase	gnl|CDD|235448	PRK05414, PRK05414, urocanate hydratase; Provisional.	0

Protein sequences

>NZ_CP017146.1|WP_161885398.1|985347_986325_+|hypothetical-protein
MTASDHTRAADGLLFASELTRGFGTDLRPRGLIRAGRLYRVARGQYIDATAWANLTADDRYVVRVAGAARARSASMVVSHQSAAALWGLPLLDGRTADVHFTIERASGGRSDPGIRKHAVGIDAEDVVTLDGLLVTSIARTVVDIAATLDLTAAVVVADRALHLDRFGHEAPLATREELFGVIERSLPLRGSVRARAVIAFGTHLSGSPGESASRVNIALNGFPEPVLQQTFTIDGREYDTDFYWREQDAIGESDGRGKYFEARYRRGRSPEDVHFAEKTREDALRRKVRAFTRWDFQTGMSQQRLRRRLLELDLPVGRPRLLRH
>NZ_CP017146.1|WP_161885397.1|984275_985244_+|DNA-topoisomerase-IB
MPRLRRSDSSGAGLRRVRAGRGFSYKDVDGRPITDPDLRARIEHLAIPPAWTDVWIAPYPNGHVQATGIDAAGRRQYIYHPTWREQKDRIKFDRALRLAESLPTARRRVTIDLRGDEPTKQRTLAAAFRMLDTGSLRVGSERYAESNGSHGLSTLLCAHALVSGSTVSLSFPAKSGQPWESDITDADLATVVRSLKRRGPRARLLAYRADDGWHPISAEEINDYVREQTGGEFTAKDFRTLRGTVAAAVSLAKHGAEGTKSPRSKALAQAMRDAAEVLGNTPAIARSSYVDPRVVDHYNAGNTIDPARTESAESELRALLFR
>NZ_CP017146.1|WP_161887346.1|982806_984066_+|imidazolonepropionase
MLIENIGLLVTHDAERPERSGAAIVIENGRVAWVGDWTGAPDADERIDAGGRCAIPGFVDSHSHLVFGGDRAAEFEARMAGRRYEAGGIRSTVEATRAASDAQLLAGARRLLSEMRAQGTTTVEIKSGYGLTVADECRILSLARTLTAETTYLGAHVVPADYSGRRDDYVALVEGEMLDACAPHSRWIDVFIDDGAFTVDEARSILTAGIARGLGARVHAGQLGVSGGVRLAVELGAASVDHCTYLADADVEALAGSAGAGAMSRDAGGSAGAGAVSRDAGGTGAAADAAGVGAVWAGTVATLLPGVEFSTRSPYPDARRLLDAGVRVALASDCNPGSSYTSSMPFCIALAVREMGMTAAEAVRAATLGGAQALRRTDIGHLRVGAAADIVLLDAPSYVHLAYRPGVPLVHRVIASSTE
>NZ_CP017146.1|WP_161885396.1|981670_982555_+|formimidoylglutamase
MAELSNDPLWPRAGDWPAGRVGEYTDLAILGIPTFRTSLSPSGAGATPTAVRAALRYYSEWAGGSRWPSIADWGDVPDPDGDGEAVAAAAARLAAQHSSLLIVLGGDNAATVPAALGAWHDRLDTAGLVTLDAHHDLRDGVSNGSPVRRLLEAGLHGTRVVQIGIADFANSAQYSQRAAELGITVITRGELAHRPIADAVAEAIEIAGGAGGPVHVDLDVDVCDRAVAPGCPASVPGGISAAELRTAARAAGRHPLVESIDLTEVDATADSADGRTVRLVALCVLEAAAGWAER
>NZ_CP017146.1|WP_161885395.1|979929_981585_+|urocanate-hydratase
MSAPRPVRAARGTALQTLGWPQEAALRMLQNNLDPEVAEHPDELVVYGGTGKAARDWASYDAIVRTLTTLRGDETMLVQSGRPVGVMQTHEWAPRVLLANSNLVGDWANWDEFRRLEKLGLTMYGQMTAGSWIYIGTQGILQGTFETFAAVAEKRFGGTLAGTITLTGGLGGMGGAQPLAVTMNDGVAIVVDVDPSRIARRIEHGYLDIEARSVEHALELALDARDARRPLSIGVLGNAAAVFPDLLARGAEIDIVTDQTSAHDPLAYLPLEVSFDQWHPAREADPIGFADAARHSMARQVEAMVGFQRAGAEVFDYGNNLRTEARTAGYADAFAYPGFVPAYIRPLFAEGKGPFRWAALSGDPADIAATDRAVLEMFPENRSLQKWIPLAQKRVHFQGLPARICWLGYGERDRAGLRFNDMVASGEVAAPLVIGRDHLDSGSVASPYRETEAMKDGSDAIADWPLLNALVNTASGATWVSIHHGGGVGIGRSIHAGQVTVADGTALAAEKIARVLTNDPGMGVIRHVDAGYGEAIEVAERLAVRVPMREG
>NZ_CP017146.1|WP_161885394.1|978230_979805_+|histidine-ammonia-lyase
MDATTITRHAEVTLTAVTLTAAAPTFADVVAVARRGAHVVLAPDALEAMAASRAVIESLAEDTTPHYGVSTGFGALATRFIPLENRLALQRSLIRSHAASSGAEIEREVTRATMLLRLSTLATGRTGVRPVVAETYAALLNAGITPVIGEYGSLGCSGDLAPLAHCALAAMGEGEVRDETGRMLPAADALAAAGIRPLELREKEGLALINGTDGMLGMLVLAITDLRALVTAADLAAAMSVEGLLGSTAVFAADLQALRPHPGQADSAANIRTLLAGSPLVASHQTDECTRVQDAYSLRCAPQVHGAVRDTIAHAATVAGRELASAIDNPVVTVDRRVESNGNFHGAPIGYVLDFLAIAVADLASMSERRTDRFLDQARSGGLNPFLAGDPGVDSGHMIAQYTQAGIVSELKRLAVPASVDSIPTSAMQEDHVSMGWSAARKLRRGVDGLARVVAIELLTAARGIDMRRMPSAASTAAVISRLRENVPGPGPDRYLAPDIQAAVDLVVSGELVAAARGVAPELV
>NZ_CP017146.1|WP_161885393.1|977383_978151_-|IclR-family-transcriptional-regulator
MVDIPAARGALRILTHLARQSGPVGASAIARDLGLPRSSTYQLIRVMQEEGYVVHYPELRAYGLGSLVSEIGSSVLRATRLGRLAQPLIDRLVLEVDVPAVAQVGVLHGSDVSYVSKAAGHRAPTTVASVGVRLPAHLTATGRSMLATLPAGQVRALFPHRESLVTRRGLGPTTLRALDDILAATRSRGFAAEDGEITQGYSSVAATATDRNGYPVAAIGLTYLSVAAVAPDDIARLGAAVVAASAALTARLGGH
>NZ_CP017146.1|WP_161885392.1|975730_976924_+|elongation-factor-Tu
MAKAKFERTKPHVNIGTIGHVDHGKTTLTAAITKVLHDKYPTLNTASAFDQIDNSPEEKQRGITINISHVEYQTEKRHYAHVDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVGVPYIVVALNKTDMVDDEEILELVEIEVRELLSSQEFDGDNAPVVRVSALKALEGDEKWAATVADLMDQVDEFVPEPVRETDKPFLMPVEDVFTITGRGTVITGRVERGILKPNDEVEIVGIKEKSSKTIVTAIEMFRKTLEDARAGENVGLLLRGTKREDVERGQVVVKPGTVTPHTEFEANAYILSKDEGGRHNPFYANYRPQFYFRTTDVTGIITLPEGTEMVMPGDTTEMTVNLIQPIAMEEGLRFAIREGGRTVGAGTVVKILK
>NZ_CP017146.1|WP_161885391.1|973431_975549_+|elongation-factor-G
MAQDVLTDLHKVRNIGIMAHIDAGKTTTTERILFYTGITHKIGEVHDGAATMDWMAQEQERGITITSAATTCFWNNHQINIIDTPGHVDFTVEVERSLRVLDGAVAVFDGKEGVEPQSETVWRQADKYDVPRICFVNKMDKLGADFYYTVDTIVKRLGAKPLVIQLPIGFESTFEGVVDLVEMRALTWRGDSKGDVELGAKYTIEEIPADLVEKANEYRATLIEVVAEADDALLERFMNGDTDFTVSEIKHAIRKLTVNSEIYPVLCGSAFKNRGVQPMLDAVVDYLPTPLDVAAVEARDPRDEEKIIVRHPDSTEPFAALAFKVAVHPFFGRLTYIRVYSGRVDSGAQLINSTKGKKERIGKIFQMHANKENPVDSVTAGHIYAVIGLKDTTTGDTLCDPQNQVVLESMTFPEPVIEVAIEPKTKADQEKLGIAIQKLAEEDPTFRTEQNQDTGQTVIKGMGELHLDILVDRMKREFNVEANVGKPQVAYRETIRRVVAKHDFTHKKQTGGSGQFAKVQISLEPLEVTPDKTYEFENKVTGGRIPREYIPSIDAGIQDALQVGILAGYPMVGVKAILLDGAAHDVDSSEMAFKIAGSMAFKEAARKADPVLLEPLMAVEVRTPEEYMGDVIGDLNSRRGQIQSMEDATGVKVVRANVPLSEMFGYVGDLRSKTSGRAVYSMTFDSYSEVPRAVAEEIVQKNKGE
>NZ_CP017146.1|WP_161885390.1|972834_973305_+|30S-ribosomal-protein-S7
MPRKGPAPKRPVVADPVYGAPIVSQLVNKILLDGKKGLAERIVYDALAGVSTKNGADAVVTLKKALDNVRPTIEVKSRRVGGSTYQVPVEVKPHRANTLALRWLTTYAKGRREKTMTERLTNEILDASNGLGAAVKRREDTHKMADANKAFAHYRW
>NZ_CP017146.1|WP_147783478.1|987465_987774_+|30S-ribosomal-protein-S10
MAGQKIRIRLKSYDHEVIDSSARKIVDTVTRAGATVVGPVPLPTEKNVIVVIRSPHKYKDSREHFEKRTHKRLIDIIDPTPKAVDSLMRLDLPADVNIEIKL
>NZ_CP017146.1|WP_161885399.1|987784_988435_+|50S-ribosomal-protein-L3
MSITKTSKGLLGKKLGMTQVWDENNKLIPVTVIEISPNVVTQLRTPEIDGYSAVQIAYGQIDPRKVNKPITGHFDKAGVTPRRHVTEVRTADAAEYTLGQEIAVDIFEAGQKVDVVGTSKGKGFAGVMKRHNFKGVSSSHGSHRNHRKPGSIGASSTPSRVFKGMRMAGRMGGERVTAMNLKVHAVDLDKGLVLVKGAVPGARGRIVFVRNAVKGA
>NZ_CP017146.1|WP_161885400.1|988438_989170_+|50S-ribosomal-protein-L4
MAESNATLDVIDSKGKKVDTVELPAETFDVQTNIPLIHQVVVAQRAAARQGTHKTKGRGEVSGAGRKPFKQKGTGRARQGSIRAPQMTGGGIVHGPTPRDYAQRTPKKMIAAALKGALSDRARGGRVHVVDVLAVGDVPSTKTIVELLASIATSKHVLIVLTRDDELSAKSVRNIPSVHVLPYDQLNAYDVLVSDDIVFTKAAFDGFVAGPVASKKVKEDAMSSGKKRVSPEKATAEKEKVSA
>NZ_CP017146.1|WP_161885401.1|989166_989466_+|50S-ribosomal-protein-L23
MTGTYKDPRDIILSPVVSEKSYGLIDMGKYTFVVDPRANKTEIKLAIEKIFGVEVASINTLNKKGKTRRTKFGQGKRKDTKRAIVSLKSGSIDIFTAVG
>NZ_CP017146.1|WP_161885402.1|989482_990322_+|50S-ribosomal-protein-L2
MAIRKYKPTTPGRRGSSVADFAEITRSTPEKSLLRPLPKTGGRNNAGRITTRHIGGGHKRQYRVIDFKRNDKDGVNAKVAEIEYDPNRTARIALLHYFDGSKRYIIAPNKLSQGDIVESGASADIKPGNNLPLKNIPTGTVIHAIELKPGGGAKMARSAGASVRLVAKDGPYAQLRLPSGEIRNVDARCRATIGEVGNAEQSNINWGKAGRMRWKGVRPTVRGVAMNPVDHPHGGGEGKTSGGRHPVSPWGQKEGRTRHINKESDKLIVRRRNAGKKRK
>NZ_CP017146.1|WP_161885403.1|990334_990616_+|30S-ribosomal-protein-S19
MPRSLKKGPFVDDHLLRKVVGANAASSKNVIKTWSRRSMIIPAMLGHTIAVHDGRKHIPVFVTETMVGHKLGEFAPTRTFRGHVKDDKKGRRR
>NZ_CP017146.1|WP_161885404.1|990643_991048_+|50S-ribosomal-protein-L22
MVESIARVKHIRVTPTKARRVVNMIRGKQAMEALAILKFAPQGASEPVYKLVASAMANAKVKADASNSYLDEQDLFVSSAYVDEGTTLKRFQPRAQGRAFQILKRTSHITIVLATPDETADVTGAAQPKKAGKK
>NZ_CP017146.1|WP_161885405.1|991047_991839_+|30S-ribosomal-protein-S3
MGQKVNPYGFRLGITTDHVSRWFSDSTKVGQRYSDYVAEDIKIRNLLKTSLDRAGVARIEIERTRDRVRVDIHTARPGIVIGRRGAEAERIRTDLEKLSGKQIQLNILEVKNPEAEAQLVAQGIAEQLTARVAFRRAMRKGLQGAQRAGAKGVRIQVSGRLGGAEMSRSEFYREGRVPLHTLRANIDYGFYEAKTTFGRIGVKVWIYKGDITNKELAREQANAKSSRPDRRDDRRDGGRDGGPRRGAAAPRTEAAPAAVGAEK
>NZ_CP017146.1|WP_161885406.1|991838_992258_+|50S-ribosomal-protein-L16
MLIPRKVKHRKQHHPGRSGQATGGTTVSFGEYGIQALTPAYVTNRQIEAARIAMTRHVKRGGKVWINIYPDRPLTKKPAETRMGSGKGSPEWWIANVKPGRVLFELSGVPENVAREALTRAIHKLPLKARIIKREEGDA
>NZ_CP017146.1|WP_161885407.1|992257_992602_+|50S-ribosomal-protein-L29
MAIGSKELATVELDTFEDGRLVDELKKAKEELFNLRFQSATGQLESHGRLRAVKRDIARIYTVIHERELGIRATPAPLEVAPKATKAKKKSKADAAVEAPADEAASTDKNEEAK

Crispr_ID: NZ_CP017146_9

• CRISPR_ID: NZ_CP017146_9
• CRISPR_location: 1054422-1054537
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP017146_9

Consensus_repeat	Method
GCTTATGTCGCCTTATGTGCCGTGGACCCGACA	CRISPRCasFinder

spacers of NZ_CP017146_9

>9.1|1054455|50|NZ_CP017146|CRISPRCasFinder
AATGTGGGCGATTCGCGGGTGGGGGGCGGTGTGGCGGGCGTGAGCTGCCC

CRISPR arrays and Neighbor proteins around NZ_CP017146_9

CRISPR arrays

The CRISPR arrays of NZ_CP017146_9

>merge|NZ_CP017146|9|1054422-1054537|CRISPRCasFinder
GCTTATGTCGCCTTATGTGCCGTGGACCCGACAAATGTGGGCGATTCGCGGGTGGGGGGCGGTGTGGCGGGCGTGAGCTGCCCGCTTATGTTGCCTTATGTGCCGTGGACCCGACA

>NZ_CP017146|9|8|1054422-1054537|CRISPRCasFinder
GCTTATGTCGCCTTATGTGCCGTGGACCCGACA	AATGTGGGCGATTCGCGGGTGGGGGGCGGTGTGGCGGGCGTGAGCTGCCC
GCTTATGTTGCCTTATGTGCCGTGGACCCGACA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017146.1|WP_161885469.1|1058799_1060218_-|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274522
NZ_CP017146.1|WP_161885457.1|1043501_1043948_-|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl|CDD|379084
NZ_CP017146.1|WP_161885474.1|1067081_1067390_-|DNA-binding-protein	unknown	unknown	gnl|CDD|226219
NZ_CP017146.1|WP_161885463.1|1049510_1051271_+|PAS-domain-containing-protein	unknown	unknown	gnl|CDD|274368
NZ_CP017146.1|WP_161885468.1|1056882_1058493_+|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	unknown	unknown	gnl|CDD|234854
NZ_CP017146.1|WP_161885475.1|1067392_1067848_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NZ_CP017146.1|WP_161885472.1|1063237_1065043_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP017146.1|WP_161885458.1|1043992_1044991_+|glycerophosphodiester-phosphodiesterase	unknown	unknown	gnl|CDD|176544
NZ_CP017146.1|WP_161887354.1|1065679_1067071_+|L-serine-ammonia-lyase	unknown	unknown	gnl|CDD|273233
NZ_CP017146.1|WP_161885459.1|1045205_1047629_+|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl|CDD|273429
NZ_CP017146.1|WP_161885461.1|1048765_1049116_+|response-regulator	unknown	unknown	gnl|CDD|381099
NZ_CP017146.1|WP_161885466.1|1053402_1054290_+|succinate--CoA-ligase-subunit-alpha	unknown	unknown	gnl|CDD|180194
NZ_CP017146.1|WP_161885471.1|1061423_1063241_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP017146.1|WP_161885473.1|1065094_1065496_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161885467.1|1056292_1056886_+|phosphoribosylglycinamide-formyltransferase	unknown	unknown	gnl|CDD|235544
NZ_CP017146.1|WP_161885460.1|1047734_1048742_+|response-regulator	unknown	unknown	gnl|CDD|333815
NZ_CP017146.1|WP_161885462.1|1049112_1049514_+|response-regulator	unknown	unknown	gnl|CDD|333815
NZ_CP017146.1|WP_161885465.1|1052198_1053368_+|ADP-forming-succinate--CoA-ligase-subunit-beta	unknown	unknown	gnl|CDD|234813
NZ_CP017146.1|WP_161885470.1|1060314_1061097_+|N(G),N(G)-dimethylarginine-dimethylaminohydrolase	unknown	unknown	gnl|CDD|224747
NZ_CP017146.1|WP_161885464.1|1051250_1052030_-|DUF2236-domain-containing-protein	unknown	unknown	gnl|CDD|378343

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP017146.1|WP_161885469.1|1058799_1060218_-|FAD-dependent-oxidoreductase	gnl|CDD|274522	TIGR03329, Phn_aa_oxid, putative aminophosphonate oxidoreductase. This clade of sequences are members of the pfam01266 family of FAD-dependent oxidoreductases. Characterized proteins within this family include glycerol-3-phosphate dehydrogenase (1.1.99.5), sarcosine oxidase beta subunit (1.5.3.1) and a number of deaminating amino acid oxidases (1.4.-.-). These genes have been consistently observed in a genomic context including genes for the import and catabolism of 2-aminoethylphosphonate (AEP). If the substrate of this oxidoreductase is AEP itself, then it is probably acting in the manner of a deaminating oxidase, resulting in the same product (phosphonoacetaldehyde) as the transaminase PhnW (TIGR02326), but releasing ammonia instead of coupling to pyruvate:alanine. Alternatively, it is reasonable to suppose that the various ABC cassette transporters which are also associated with these loci allow the import of phosphonates closely related to AEP which may not be substrates for PhnW.	9.11621e-61
NZ_CP017146.1|WP_161885457.1|1043501_1043948_-|zinc-ribbon-domain-containing-protein	gnl|CDD|379084	pfam13240, zinc_ribbon_2, zinc-ribbon domain. This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR. pfam12773.	0.00108879
NZ_CP017146.1|WP_161885474.1|1067081_1067390_-|DNA-binding-protein	gnl|CDD|226219	COG3695, COG3695, Predicted methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	1.11009e-23
NZ_CP017146.1|WP_161885463.1|1049510_1051271_+|PAS-domain-containing-protein	gnl|CDD|274368	TIGR02966, Phosphate_regulon_sensor_protein_PhoR, phosphate regulon sensor kinase PhoR. Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems].	3.70908e-58
NZ_CP017146.1|WP_161885468.1|1056882_1058493_+|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	gnl|CDD|234854	PRK00881, purH, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional.	0
NZ_CP017146.1|WP_161885475.1|1067392_1067848_-|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	7.75078e-10
NZ_CP017146.1|WP_161885472.1|1063237_1065043_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	4.51771e-157
NZ_CP017146.1|WP_161885458.1|1043992_1044991_+|glycerophosphodiester-phosphodiesterase	gnl|CDD|176544	cd08602, GDPD_ScGlpQ1_like, Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in a group of putative bacterial and eukaryotic glycerophosphodiester phosphodiesterases (GP-GDE, EC 3.1.4.46) similar to Escherichia coli periplasmic phosphodiesterase GlpQ, as well as plant glycerophosphodiester phosphodiesterases (GP-PDEs), all of which catalyzes the Ca2+-dependent degradation of periplasmic glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols. The prototypes of this family include putative secreted phosphodiesterase encoded by gene glpQ1 (SCO1565) from the pho regulon in Streptomyces coelicolor genome, and in plants, two distinct Arabidopsis thaliana genes, AT5G08030 and AT1G74210, coding putative GP-PDEs from the cell walls and vacuoles, respectively.	1.77637e-96
NZ_CP017146.1|WP_161887354.1|1065679_1067071_+|L-serine-ammonia-lyase	gnl|CDD|273233	TIGR00720, hypothetical_protein_NEICINOT_00681, L-serine dehydratase, iron-sulfur-dependent, single chain form. This enzyme is also called serine deaminase and L-serine dehydratase 1. L-serine ammonia-lyase converts serine into pyruvate in the gluconeogenesis pathway from serine. This enzyme is comprised of a single chain in Escherichia coli, Mycobacterium tuberculosis, and several other species, but has separate alpha and beta chains in Bacillus subtilis and related species. The beta and alpha chains are homologous to the N-terminal and C-terminal regions, respectively, but are rather deeply branched in a UPGMA tree. This enzyme requires iron and dithiothreitol for activation in vitro, and is a predicted 4Fe-4S protein. Escherichia coli Pseudomonas aeruginosa have two copies of this protein. [Energy metabolism, Amino acids and amines, Energy metabolism, Glycolysis/gluconeogenesis].	0
NZ_CP017146.1|WP_161885459.1|1045205_1047629_+|UvrD-helicase-domain-containing-protein	gnl|CDD|273429	TIGR01073, ATP-dependent_DNA_helicase_PcrA, ATP-dependent DNA helicase PcrA. Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP017146.1|WP_161885461.1|1048765_1049116_+|response-regulator	gnl|CDD|381099	cd17546, REC_hyHK_CKI1_RcsC-like, phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC. This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.48063e-19
NZ_CP017146.1|WP_161885466.1|1053402_1054290_+|succinate--CoA-ligase-subunit-alpha	gnl|CDD|180194	PRK05678, PRK05678, succinyl-CoA synthetase subunit alpha; Validated.	0
NZ_CP017146.1|WP_161885471.1|1061423_1063241_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.18464e-144
NZ_CP017146.1|WP_161885467.1|1056292_1056886_+|phosphoribosylglycinamide-formyltransferase	gnl|CDD|235544	PRK05647, purN, phosphoribosylglycinamide formyltransferase; Reviewed.	3.16e-89
NZ_CP017146.1|WP_161885460.1|1047734_1048742_+|response-regulator	gnl|CDD|333815	pfam00072, Response_reg, Response regulator receiver domain. This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.	8.39337e-30
NZ_CP017146.1|WP_161885462.1|1049112_1049514_+|response-regulator	gnl|CDD|333815	pfam00072, Response_reg, Response regulator receiver domain. This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.	1.83556e-28
NZ_CP017146.1|WP_161885465.1|1052198_1053368_+|ADP-forming-succinate--CoA-ligase-subunit-beta	gnl|CDD|234813	PRK00696, sucC, ADP-forming succinate--CoA ligase subunit beta.	0
NZ_CP017146.1|WP_161885470.1|1060314_1061097_+|N(G),N(G)-dimethylarginine-dimethylaminohydrolase	gnl|CDD|224747	COG1834, COG1834, N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism].	2.47288e-34
NZ_CP017146.1|WP_161885464.1|1051250_1052030_-|DUF2236-domain-containing-protein	gnl|CDD|378343	pfam09995, DUF2236, Uncharacterized protein conserved in bacteria (DUF2236). This domain, found in various hypothetical bacterial proteins, has no known function. This family contains a highly conserved arginine and histidine that may be active site residues for an as yet unknown catalytic activity.	8.972e-53

Protein sequences

>NZ_CP017146.1|WP_161885466.1|1053402_1054290_+|succinate--CoA-ligase-subunit-alpha
MSIFLDENSKIIVQGLTGSEGTKHAGRMLESGSNIVGGVNPRKAGTTVSIGGHELPIFGSVAEAMASTGANVSVIFVPPAFAKGAVIEAVDARIELAIVITEGIPIHDSAEFWAHAKANGNTTRIIGPNCPGIISPGKSNAGIIPSTITGPGPIGLVSKSGTLTYQMMFELRDLGFSTGIGIGGDPIIGTTHIDALAAFEADPDTKAIVMIGEIGGDAEERAAEFIQANVTKPVVAYVAGFTAPEGKTMGHAGAIVSDGAGTAQGKKEALEAAGVRVGKTPSETASIMREVFASL
>NZ_CP017146.1|WP_161885465.1|1052198_1053368_+|ADP-forming-succinate--CoA-ligase-subunit-beta
MDLFEYQARDVFESYGVPVLAGIIADSPEEVRAAADKLGGTVVVKAQVKVGGRGKAGGVKVAHNPQDAEEASKAIFGLDIKGHVVHRVMVAAGARIAQEFYFSVLLDRANRSFLSLASYEGGVEIEILAVERPEALAKVEVDPIAGIDLAKATEIATAASFPAELVPKIAPVIVKLYEVFVGEDATLVEVNPLVLTEEGDIVALDGKVTLDENAEFRHEGHSALVDTASEDPLEAKAKKANLNYVKLDGEVGIIGNGAGLVMSTLDVVSYAGEKHGHVKPANFLDIGGGASAEVMAAGLDVILGDEQVKSVFVNVFGGITSCDAVANGIVGALAVLGDAATKPLVVRLDGNNVVEGRQILADAGHPLVTVVDTMDEAADKAAELAYAAR
>NZ_CP017146.1|WP_161885464.1|1051250_1052030_-|DUF2236-domain-containing-protein
MQAEREERGLADIGAEAVLIAGGGRAILLQLANPAIGHAIARHSNFADGPIDRLRHTLGYVYAIVDGSPAQVAAVRERVNRRHAPVKSSPGAAPPYDATDAALQLWVAATLYDTAMLVHERLIGTLSDADLDRVYADYAAIGTSLQVPPELWPVDRAAFSEYWRSQLSGLRVDATTRGVAEALLYPRTGPLWLRLAMPLARLVTAGLLPASIRTQFRFAWGPRRERRFELAIAAIRAVNRVLPSRLRRWPKNALLREIG
>NZ_CP017146.1|WP_161885463.1|1049510_1051271_+|PAS-domain-containing-protein
MTLTAAVNRLATPNPSPLLKQAPMTILFGAAVVIVAVNPGSVTSVASVVAATVAVVVATVLAGVLTAISTIAKFALLVPALDLVAIGFLRFGTGEGLSNFSALIILPIIWFAAEEGREHIWFAFIGTAIVLIFPSVAGLSDSSALSVLLRAAFSAAVFTIAAAVINELSRQARLRLSSVRRLAEERRSALESNERRTNQLAESEASLRQAQRMFRGLWGAVTEQAVIGTDLTGMIDAWNPGAALMLRIGADRVEDKRHVDEFHLAHELEDRARELNYPAGATVLNPGFSALVEEARLGSAEVREWTYRRADGTELPVELSVTARLDDDGETVGYLFVAHDRTKAHEVAKLKDDFVGLISHELRTPLSSILGYLELMRDDDDEELTDTQLQYLGVAERNANRLLVLIGDLLFTAQVESGKFNLEQHVQSMSPIVSAAVDSARPAAVRAGVTLVVEIVDGGMVRGDSVRLGQACDNLISNAIKFTPAGGTVTVSLHGEAHKVIVTVSDTGMGIPESEIDQLFSRFFRASTATRNAVPGVGLGLTITKAIVTAHGGQMSVRSEEGVGTNFSMTLPLEQPARVRSADLAQ
>NZ_CP017146.1|WP_161885462.1|1049112_1049514_+|response-regulator
MSAAAHRASVLVADDDADIRVLVGIAVRKSGLELIGAAIDGTEAWELVRELKPDLLVTDVSMPGLTGLELCSLIRDDDELSGTRVVLLSAAVDEAAHAAGRDAGAVDYLIKPFSPRELAERLVELTQSSTARK
>NZ_CP017146.1|WP_161885461.1|1048765_1049116_+|response-regulator
MNVLVVDDSADQRHLLRRYFELAGCDVVVADSAESAITAYERLTPDLAVVDLILPGMDGWALTARIQADRPECAVAITSVLDAGDYPKAVAALPKPVSRASVRELLANTASKWAVL
>NZ_CP017146.1|WP_161885460.1|1047734_1048742_+|response-regulator
MQDPYRVVVVEDDLDVAMYTKTVLEKRAGCIVVAVSDPSKVLEAVADFKPDVVITDIEMPGASGLDLISQIRELQPGTPVIVMTAHVSIDYAVTALRNQASEFLTKPVSSADLVAHVTRLGEESRAPRASTARQIVLAIGAHPDDVEIAVGGILAAHRAAGDEVTVLTLSKGTRQGGIRVAWKEGSAAAATIGARLILEDNPEAEIGTPELTVATIKRVVDEVKPTIVYMHSTNDRHQSHRAVHDAGVVSTEQVRMIACYQGSSATVDFHPNRFVTIDGFTDAKLAMLACFAVHDDRPAYLDPDLALATARYWSRYGHGTSCEPLEVLRESLAVS
>NZ_CP017146.1|WP_161885459.1|1045205_1047629_+|UvrD-helicase-domain-containing-protein
MTFILDPAQPSSGQSRLLEGLNPAQRVAVEYRGPALLIVAGAGSGKTSVLTRRIAGLLESSEAWPSQILAITFTNKAAAEMRERVQELVGRGAEGMWISTFHSACVRILRREAEHFGFTKKFTIYDSADSRALLKRIIKELNADTFGFTVSSASGRISKLKNELQDVESYARGANFNDPTEAMFLEIFRAYTRGLSSANAFDFDDLIGQTVYLFRAFPQVAALYQRRFRHILVDEYQDTNHAQYALIRELTRAPRTDLLAGATGFDGRELRDPTRELEPASLTVVGDSDQSIYAFRGADIRNIVEFERDFSGAKVVLLEQNYRSTQNILSAANAVISNNFDRKDKKLFTTVGDGEKIVGFTGYSQHDEAQFIADEVVTLHETGVQYRDIAVFYRTNAQTRALEEVFIRSALPYRVLGGTKFYERAEIKDVMGYLIAVANPADPMALRRIMNTPKRGIGPATEAALQSHADKSEKTLREAMREADQLGLGPKVTGAILRLGAILDEVALTADTAPVADVLTALLTKTKFVEALRASRDPQDEARAENVEELVAVTKEFQKNNPEGTLIDFLTETSLVAAADDLDDSSGTVSLMTLHTAKGLEYEAVFLTGVEEDLLPHRMSAGEPGGPAEERRLFYVGITRARRRLYLSLAMTRAQFGEVNVAMPSRYLQEIPADLIDWRQSPGMANSRGGTQPRAINANRAGFGAAPALGGGSDYSLDAGAPGATALARAAHNAARPKTEWTSGVTNTVRDNGDLTLKPGDRIRHLDFGEGRVSAVSGSGTKSIAEVQFETAGRKRLLIKISPIEKI
>NZ_CP017146.1|WP_161885458.1|1043992_1044991_+|glycerophosphodiester-phosphodiesterase
MNLLGPDAPIVIAHRGASGYHPEHTHSAYRVAIEHGADAVEPDLVASRDGVLVIRHENEMSKSTDVAERPEFADRRTTKSIDGVSRTGWFTEDFTWAELSTLRATEPLPGIRFASLVHSGTEPIIRLEDLLALLDEQERQVGAVLEIKHASYFAGIGLPLDVLLAGALETAGWTGDPRLTIESFELTFFDKLRERGVAGRFIYLIEPKGVPFDRPHASYASALTDEGLRELRGHVHGISVSKKLLLQQGGDGVVSSTDLVERAHAAGLLIYGWTLRAENKFLTGGHQGGGAASDHGDWPTEFGLILASGIDGVFSDHPDLALEVRRNLATPA
>NZ_CP017146.1|WP_161885457.1|1043501_1043948_-|zinc-ribbon-domain-containing-protein
MGVCVNCGGALEDRWKFCIFCGTPVSRAPISEPAAEPARGPDAELDAEQPFSHPGGEPDISPPIDDGPNWEPEPEPEPEPSRPPIPAAIRTFVQVEIPNEDEDDPAARHIRPRFRPRRVDIPLLLGIALGIAGFALIIYMIAVLSGQG
>NZ_CP017146.1|WP_161885467.1|1056292_1056886_+|phosphoribosylglycinamide-formyltransferase
MLSLVVLISGAGSNLRSLLEAAEDAEYPARVLAIGADRLADGLEHAEVFGIPSFTVPFTSYSDRDAWGDELLEQVQFWNPDLVILSGFMRLLPPRVVAAFAPRLINTHPAYLPEFPGAHGVRDAIAAGVAETGASVIVVDNGVDSGPIIAQRRVPIVPDDTEQTLHDRIKLVERELLVQAVLDIANGTVNLEELSHS
>NZ_CP017146.1|WP_161885468.1|1056882_1058493_+|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase
MSAPSHAPSDYRERDAIPITRALISVSDKTGLLELAAALAAAGVEIVSTGSTAKTIADAGHPVTEVGQVTGFPESLDGRVKTLHPSIHAGILADLRLASHEAELAELGIHPFELVVVNLYPFVETVASGVTGDAAVEQIDIGGPAMVRASAKNHANVAIAVSPAGYPQIIKAVTLGGTTLAQRQRLAGEAFAHTSAYDTAVSEFFAANIGIRAAHPVTDAAFPASVSATYELKQVLRYGENAHQAAALYTREWPGVAQATQLQGKEMSYNNYVDADGAVRAAYDFSEPAVAIIKHAQPCGIAVAGGSSGSIAAAHIRAHECDPVSAFGGVIAANRIVTLAMAEQVRDIFTEVVIAPGFEPAALEVLASKKNLRLLQLPDGYRRDEREFRQISGGLLVQDPDVFDDFSSAGWQLVAGAEADAATRADLEFAWRAVRAVKSNAILLATGGASVGVGMGQVNRVDSCQLAVRRAGARAVGSVAASDAFFPFADGLEILLEAGVKAIAQPGGSVRDEEVIDAAKKAGVTMYSTGERHFYH
>NZ_CP017146.1|WP_161885469.1|1058799_1060218_-|FAD-dependent-oxidoreductase
MHTTVFERNAPSAAAIDHSLAGVRRSPFWLEDAAAATYPRLTGGLECDLAVVGAGYCGLWTAIKAKRADPSRRVVVLEAKTVGWAASGRNGGFVEASLTHGEDNGVARFPAEIDRLNELGLVNLDTIEATVAELGIDCDWERNGAIDLAVEPYQLEALREWELTPGQVFLGASELAREVSSPTYLGGVWNTRSSALVHPGKLAAELARVASELGVEIFEHSKVDAVVTRDSARVILPTRTGSVFASSVALATNVFPSLLRRNRLQTVPVYDYVLITEPLSAEQLVSIGWSNRQGLGDGANQFHYYRLSADNRILFGGYDAINHFGQRVDPRYENRPESYRRLASHFLTTFPQLAGIRFSHRWAGPIDTSTRFCAFFGTARQGRVAYAAGFTGLGVASTHFAADVMLDLLSGVPSELTELEMVRSRPLPFPPEPAASIGIQLTRWSLDRADHNYGRRNLMLRGLDAVGLGFDS
>NZ_CP017146.1|WP_161885470.1|1060314_1061097_+|N(G),N(G)-dimethylarginine-dimethylaminohydrolase
MSPNVAAPSPRALVRPPAATLARGEVTHVVRTPVDVALAAEQWRGYVDALAQADFEIIEVAADDTLADSVFVEDAVVILGRVAVLTSPGALSRRAEIAGVEAVIAGLGLVERRIDLPGTLDGGDVLKIGATVYVGRGGRTNAEGIRQLTAIAADEGFDLVTVPVTRVLHLKSAVTALPDGTVIGHAPLVEHPELFDRFLEVPEETGAAVIVLAPDAVLMAASAPLTAVLFAEMGYRVVTVDISEFEKLEGCVTCLSVRIR
>NZ_CP017146.1|WP_161885471.1|1061423_1063241_+|ABC-transporter-ATP-binding-protein
MTLGTTVSTLPGPPKKATTFASIARLHPYAKSALPRIYLGMGAAMIAALVALTIPQVLGSLVDGPLQDGDSSQIWWPVAIVLALGVLEAAMIWLRRWFVLQPGTHVEAGMRNSFYAQLQDLPVSFHDRWPSGQLLSRAISDLNLIRRWVSFGLVLLVVNVLTILIGLVFLISINWMLGLLFAVCSIPLWVYGYVFEKKYSIVSRRSQDQSGDLATAVEESVHGIRVLKAFGRGSHALKNFSSQAEDLRGTEIEKARAIAGIWLWLLLVPDVTFALSLLGGVWLAADGQLTAGDLVAFFATATVLRWPVESIGYLLSMTFDARTAADRFFEVMDEINTITDPEDPATIASPEGRLVFADVHFRYPDSPAQYADLLDGIDLELEPGETMALVGLTGSGKSTMTALTTRLYDVTSGRIILDGVDIRDLGRTELRRHIAMAFEDATLFSATVRDNVLLGRPEGTDAELADALEIAQAGFVYDLPDGIDTMVGEEGMSLSGGQRQRLALARAVAATPRVLVLDDPLSALDVDTEALVEAALRRVLASTTALIVAHRPSTVMLADRVALLERGRVTAIGRHSELLATNDHYRFVISSLEDEQARELKEANA
>NZ_CP017146.1|WP_161885472.1|1063237_1065043_+|ABC-transporter-ATP-binding-protein
MSVVGVNGEERGDFSAAESRHIRRRSIRLLGSLLNPVRARLVLTMAVVVVSTIAQVAGPALIAIGIDHGLPALLEGNATPLVLVVAAYLLTGVIGAALIAWYTVLAARVSQAILIDLRKRVFLHTQKLSLEFHESYTSGKIIARQTSDLDAIRELLDSGLSQLVQGALYMIFIAAALFSIDWVSGVVLVVFLVPLAFLARWFQVQSQRVFRQTRVASARLIVHFVETMTGIRAVKAFRTEKRNEEEFAGLVEGYRERNARVIQLFGVFDPGLVLIGNVALGIVLLAGGLRVADGGLDIGVLLAALLYTRQFFAPAQEMAMFYNSYQSAAAALEKISGVLEETPSVADPTRPVDLWRAKGRVRFDGVEFAYKEGSVVLPEFDLELPAGQVVALVGSTGAGKSTLAKLLSRFYDPTTGAVSLDGLDLRMLHPKDLRRAIVMVTQEAYLFSGSVSENIALGKPEATREEIVAAAKAVGAHEFIEALPDGYETDVNKRGGRVSAGQRQLISFARAFLADPVVLILDEATASLDIPSERLVQEGLTTLLADRTAVIIAHRLSTVAIADRVLVMEHGRIVEDGTPRDLIAGTGRFSQLHAAWRDSLV
>NZ_CP017146.1|WP_161885473.1|1065094_1065496_-|hypothetical-protein
MRTLLMAPAFAAALLALSGCTIVEQFLPSQTESRFQDFTAFQGGAGEEFTSLAWVPSDSILLATKDSDHDQRRMLKFESETGVTDAGCVPGLLAGEAPFETVWWPSGEALTGVICDGTWRVFAVADTWYAWTQ
>NZ_CP017146.1|WP_161887354.1|1065679_1067071_+|L-serine-ammonia-lyase
MVRASNGRALVHRVSALDLFSIGIGPSSSHTVGPMRAATAFARELESGDLLPQTSGLRMTLYGSIAATGVGHGTLGALAAGLRGEDPATIDPALVARAWDEALAAGGIALLGGPAIALAATDMRYEPFTRMPAHPNGIRFEALDAAGLVLHDALYYSVGGGFIERDGSAPAPEPEPGPYPYRTAAELLAYCTESGLEIADIALANELAIATEDEVNARLDAVWHAMRECVEAGMATEGVLPGWLRVPRRSAGIAEHLRERESNGDTDTAVEWLQCYAIAVNEQNAAGARVVTAPTNGAAGIIPAVGYYAMKMRGMVTPEQSRRYLLTAGAIGSLCKMNASISGAEAGCQGEVGSACSMAAAGITAHLGGTPAQVENAAEVAMEHHLGLTCDPIGGFVQVPCIERNAIAAATAVSASRLALMGDGTHLVSLDTVIETMRQTGRDMSENYKETSRAGLAVNVVEC
>NZ_CP017146.1|WP_161885474.1|1067081_1067390_-|DNA-binding-protein
MIADDFVSRVVEVVESIPPGRVMTYGDVAAAIGSRAARAVGSVMAHYGSELPWWRVIRASGHPALDHEAAALEHFRAEGTPLARAGSGSYRVRLDLARYTPG
>NZ_CP017146.1|WP_161885475.1|1067392_1067848_-|GNAT-family-N-acetyltransferase
MGELKLEELSAKNAVAANNLSLKPGQEQFIAPVSYAMAGPFLDPNTGWSRVVTDEDDGVVGFIMANFDPEALEDEFRSCIWRMNVDADAQGKGAGRFVVEATADEARKRGFDRLTVLWEPGDDSPEDFFLRVGFVVVGETPYGEKIGALTL

Crispr_ID: NZ_CP017146_10

• CRISPR_ID: NZ_CP017146_10
• CRISPR_location: 1209340-1209499
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers
• Cas_protein_info: csa3

Consensus repeat of NZ_CP017146_10

Consensus_repeat	Method
CCCGCGATAGCGCGTTGTGCCCGCG	CRISPRCasFinder

spacers of NZ_CP017146_10

>10.1|1209365|53|NZ_CP017146|CRISPRCasFinder
TGCCGGGCGATTGGTGCGGGTTGTTGAGTCTCGCGTTGCGGTGACGCGCGTGG
>10.2|1209443|32|NZ_CP017146|CRISPRCasFinder
ATAGCGCGTTGTGCCCGCGATAGCGCGTTGTG

CRISPR arrays and Neighbor proteins around NZ_CP017146_10

CRISPR arrays

The CRISPR arrays of NZ_CP017146_10

>merge|NZ_CP017146|10|1209340-1209499|CRISPRCasFinder
CCCGCGATGACGCGCATGACCGGCGTGCCGGGCGATTGGTGCGGGTTGTTGAGTCTCGCGTTGCGGTGACGCGCGTGGCTGGCGTTGGCATGTTCTACCCGCGATAGCGCGTTGTGCCCGCGATAGCGCGTTGTGCCCGCGATAGCGCGTTGTGCCCGCG

>NZ_CP017146|10|9|1209340-1209499|CRISPRCasFinder
CCCGCGATGACGCGCATGACCGGCG	TGCCGGGCGATTGGTGCGGGTTGTTGAGTCTCGCGTTGCGGTGACGCGCGTGG
CTGGCGTTGGCATGTTCTACCCGCG	ATAGCGCGTTGTGCCCGCGATAGCGCGTTGTG
CCCGCGATAGCGCGTTGTGCCCGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017146.1|WP_161885593.1|1211316_1212207_+|UTP--glucose-1-phosphate-uridylyltransferase-GalU	unknown	unknown	gnl|CDD|224131
NZ_CP017146.1|WP_161885597.1|1215482_1216859_+|DUF2254-domain-containing-protein	unknown	unknown	gnl|CDD|378351
NZ_CP017146.1|WP_161885585.1|1197798_1201707_+|amino-acid-adenylation-domain-containing-protein	unknown	unknown	gnl|CDD|274093
NZ_CP017146.1|WP_161885586.1|1201712_1203038_+|M1-family-metallopeptidase	unknown	unknown	gnl|CDD|341066
NZ_CP017146.1|WP_161885589.1|1205081_1208867_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|224037
NZ_CP017146.1|WP_161885592.1|1210670_1211249_-|5-formyltetrahydrofolate-cyclo-ligase	unknown	unknown	gnl|CDD|274270
NZ_CP017146.1|WP_161885587.1|1203034_1203682_-|4'-phosphopantetheinyl-transferase-superfamily-protein	unknown	unknown	gnl|CDD|225002
NZ_CP017146.1|WP_161885582.1|1194969_1195938_+|metalloregulator-ArsR/SmtB-family-transcription-factor	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|319973
NZ_CP017146.1|WP_161887370.1|1209737_1210187_-|large-conductance-mechanosensitive-channel-protein-MscL	unknown	unknown	gnl|CDD|376605
NZ_CP017146.1|WP_161885588.1|1203678_1205004_-|hypothetical-protein	unknown	unknown	gnl|CDD|224117
NZ_CP017146.1|WP_161887371.1|1214103_1214739_-|ion-transporter	unknown	unknown	gnl|CDD|366146
NZ_CP017146.1|WP_161885590.1|1208976_1209222_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161885598.1|1217045_1218032_-|M56-family-metallopeptidase	unknown	unknown	gnl|CDD|320685
NZ_CP017146.1|WP_161885581.1|1193522_1194854_+|NAD(P)-binding-domain-containing-protein	unknown	unknown	gnl|CDD|379355
NZ_CP017146.1|WP_161885595.1|1212926_1213850_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161885584.1|1196434_1197103_+|arsenate-reductase-ArsC	unknown	unknown	gnl|CDD|319973
NZ_CP017146.1|WP_161885596.1|1214815_1215328_-|DUF421-domain-containing-protein	unknown	unknown	gnl|CDD|225205
NZ_CP017146.1|WP_161885583.1|1196021_1196432_+|arsenate-reductase-ArsC	unknown	unknown	gnl|CDD|319973
NZ_CP017146.1|WP_161885594.1|1212211_1212874_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|224584
NZ_CP017146.1|WP_161885591.1|1210197_1210641_-|FmdB-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225210

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP017146.1|WP_161885582.1|1194969_1195938_+|metalloregulator-ArsR/SmtB-family-transcription-factor	csa3	COG0640_csa3_CAS-I-A	9.4e-15	49.8	0.2

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP017146.1|WP_161885593.1|1211316_1212207_+|UTP--glucose-1-phosphate-uridylyltransferase-GalU	gnl|CDD|224131	COG1210, GalU, UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane].	3.12653e-147
NZ_CP017146.1|WP_161885597.1|1215482_1216859_+|DUF2254-domain-containing-protein	gnl|CDD|378351	pfam10011, DUF2254, Predicted membrane protein (DUF2254). Members of this family of bacterial proteins comprises various hypothetical and putative membrane proteins. Their exact function, has not, as yet, been defined.	3.7783e-115
NZ_CP017146.1|WP_161885585.1|1197798_1201707_+|amino-acid-adenylation-domain-containing-protein	gnl|CDD|274093	TIGR02353, NON-RIBOSOMAL_PEPTIDE_SYNTHETASE, non-ribosomal peptide synthetase terminal domain of unknown function. This domain is found exclusively in non-ribosomal peptide synthetases and always as the final domain in the polypeptide. This domain is roughly 700 amino acids in size and is found in polypeptides roughly twice that size.	0
NZ_CP017146.1|WP_161885586.1|1201712_1203038_+|M1-family-metallopeptidase	gnl|CDD|341066	cd09603, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains mostly bacterial and some archaeal M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	8.71221e-166
NZ_CP017146.1|WP_161885589.1|1205081_1208867_+|AAA-family-ATPase	gnl|CDD|224037	COG1112, COG1112, Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair].	1.7455e-14
NZ_CP017146.1|WP_161885592.1|1210670_1211249_-|5-formyltetrahydrofolate-cyclo-ligase	gnl|CDD|274270	TIGR02727, Uncharacterized_protein_YqgN, 5,10-methenyltetrahydrofolate synthetase. This enzyme, 5,10-methenyltetrahydrofolate synthetase, is also called 5-formyltetrahydrofolate cycloligase. Function of bacterial proteins in this family was inferred originally from the known activity of eukaryotic homologs. Recently, activity was shown explicitly for the member from Mycoplasma pneumonia. Members of this family from alpha- and gamma-proteobacteria, designated ygfA, are often found in an operon with 6S structural RNA, and show a similar pattern of high expression during stationary phase. The function may be to deplete folate to slow 1-carbon biosynthetic metabolism. [Central intermediary metabolism, One-carbon metabolism].	2.05042e-57
NZ_CP017146.1|WP_161885587.1|1203034_1203682_-|4'-phosphopantetheinyl-transferase-superfamily-protein	gnl|CDD|225002	COG2091, Sfp, Phosphopantetheinyl transferase [Coenzyme metabolism].	5.00329e-21
NZ_CP017146.1|WP_161885582.1|1194969_1195938_+|metalloregulator-ArsR/SmtB-family-transcription-factor	gnl|CDD|319973	cd16345, LMWP_ArsC, Arsenate reductase of the LMWP family. Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).	4.07336e-43
NZ_CP017146.1|WP_161887370.1|1209737_1210187_-|large-conductance-mechanosensitive-channel-protein-MscL	gnl|CDD|376605	pfam01741, MscL, Large-conductance mechanosensitive channel, MscL.	1.89085e-46
NZ_CP017146.1|WP_161887371.1|1214103_1214739_-|ion-transporter	gnl|CDD|366146	pfam00520, Ion_trans, Ion transport protein. This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.	0.00244074
NZ_CP017146.1|WP_161885588.1|1203678_1205004_-|hypothetical-protein	gnl|CDD|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	0.000566996
NZ_CP017146.1|WP_161885598.1|1217045_1218032_-|M56-family-metallopeptidase	gnl|CDD|320685	cd07326, M56_BlaR1_MecR1_like, Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase. This family contains peptidase M56, which includes zinc metalloprotease domain in MecR1 as well as BlaR1. MecR1 is a transmembrane beta-lactam sensor/signal transducer protein that regulates the expression of an altered penicillin-binding protein PBP2a, which resists inactivation by beta-lactam antibiotics, in methicillin-resistant Staphylococcus aureus (MRSA). BlaR1 regulates the inducible expression of a class A beta-lactamase that hydrolytically destroys certain ?-lactam antibiotics in MRSA. Both, MecR1 and BlaR1, are transmembrane proteins that consist of four transmembrane helices, a cytoplasmic zinc protease domain, and the soluble C-terminal extracellular sensor domain, and are highly similar in sequence and function. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. All members contain the zinc metalloprotease motif (HEXXH). Homologs of this peptidase domain are also found in a number of other bacterial genome sequences, most of which are as yet uncharacterized.	1.19483e-28
NZ_CP017146.1|WP_161885581.1|1193522_1194854_+|NAD(P)-binding-domain-containing-protein	gnl|CDD|379355	pfam13738, Pyr_redox_3, Pyridine nucleotide-disulphide oxidoreductase.	3.70095e-23
NZ_CP017146.1|WP_161885584.1|1196434_1197103_+|arsenate-reductase-ArsC	gnl|CDD|319973	cd16345, LMWP_ArsC, Arsenate reductase of the LMWP family. Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).	1.64208e-45
NZ_CP017146.1|WP_161885596.1|1214815_1215328_-|DUF421-domain-containing-protein	gnl|CDD|225205	COG2323, COG2323, Predicted membrane protein [Function unknown].	3.39864e-33
NZ_CP017146.1|WP_161885583.1|1196021_1196432_+|arsenate-reductase-ArsC	gnl|CDD|319973	cd16345, LMWP_ArsC, Arsenate reductase of the LMWP family. Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).	1.02869e-52
NZ_CP017146.1|WP_161885594.1|1212211_1212874_+|GNAT-family-N-acetyltransferase	gnl|CDD|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	1.47849e-28
NZ_CP017146.1|WP_161885591.1|1210197_1210641_-|FmdB-family-transcriptional-regulator	gnl|CDD|225210	COG2331, COG2331, Uncharacterized protein conserved in bacteria [Function unknown].	7.6761e-23

Protein sequences

>NZ_CP017146.1|WP_161885590.1|1208976_1209222_+|hypothetical-protein
MRRGAVEADVAREGEVAGDATRSDAATADEVRARAAGTRRRRRVTTQAVPGSDPTPQNEPARHAENENDERLKADKPPHWG
>NZ_CP017146.1|WP_161885589.1|1205081_1208867_+|AAA-family-ATPase
MWRAEKREETGDSLSESDENPTHAERQVTSPHSLASGDPSYRLGNVAEPTWTGWRDELSRVGGRSPLLHFVDAPRTRIELSTTHPGGLAQFITGKTTLLSSLIRDDLALRAAKMAASAIATKGVELATARGIDSVHLGIGIAEWQFESEDFCAPILLRPLAIRRYGRDFEVRLRGVAFLNPELERALKTQFDIELDAAAFAALAESDGSFKPNPVIDRLRGLTSHLEWFNVQPRLVVSSFADVQNRMVRDAAELENPILDALAGNANARWSVKQGFAPVDPQHQDLRSPETDTLLLDADSEQENVVAQIAAGNSVVVKTLPGTGGTQTIVNAIGSLVAQNKRVLVVSPRRSSLSGIRARLGDIGLGGLAVSPSTLRRDLIQSIGRNEKAKQPQIGEVDEALVRLRRVLLDYRGAIAKDDDVLGISVLDCLSELSRLALLPQPPSTTVRLSRSSVEALATERVEAATAMVHAAQLGEFKYGPGDSPWYGATFVTSEEASGAHALAKRLHQTDLPRLLVRAGELIGATHMRPFENISQLGVYLRLLTEIRDTLDRFLPVVFERSLSELITATAARRDSPEMSGANRRRLKKLAREYVRPGVHIGDLHDNLVRIQQQRLLWQRFVAEGAPPEIPVGIADVQAAWQRVEQDLASLDRPLQVTVPSKQLVNLPIAELGDRLTALAAESDVLNNLQERVEIRQRLRMLELDGLIADLASRHVPADEVASELELSWWQSALESLLDSDRALLGANTSVLDRLEADFRLVDEAHAAGSAQLLGWQLAENWNLGLVDWPDESASLKMALRRPEVSSSILQDVAPHLARAIAPVWLASPYEVDSITDAMSIDAVILVDAGAMSLAESVGSIRRAKQAVAFGDPVTQTPVPFRISIADDFEKAELPPAEPDLDATHADSALARLATLLPTLSLTRSYRAGGEDLAELVNRRFYAGKIDSLPWAGSFLGHPSLRLDFVPNGHGMPDYDSGAVESVDAEVDRVVELVLEHAATRSSESLMVITASAKHVVRVQQAVLTAVATRPELNEFLLGDSEEPFTVTTIDHAVAESRDRVIFSIGYGRTPHGRMLSDFGALGHPGGERLLAVAMTRARRSMVIVTCFEPSDIDESRMNYGAVALAEILADASARRLDEIPTASTDPMLVDLARRLRLRGLRVAVGHRGKLGLVASHGGMCLTIETDSRLMIGSGGQPSSLRESLRLRPEMLRRLGWHYLRVHSFELFSNPDAVADRIATMLGVTEAPRTEPIQIIDRPLQ
>NZ_CP017146.1|WP_161885588.1|1203678_1205004_-|hypothetical-protein
MLARTIPGLSAVADSTAVADSSAAVGAVVGAGIGAVTIGLLFAAALAVGFAVLVRRGRAASTAPKRDEIGRRANIALVRLDDDVASMRDELGFAVAQFGDARAATLAAALDNASADLASAFVLKQRLDDAASDTPTQQREWNGQILMLCETASNRLAAQRAAFDSLRGSERDAPNDLQAVRERIVREQSRLPVAHELLSRLHSRYAPAAIAPVREIPDEAERLLDAARTSADSAADNLDGTGATAVSVSIRSSEQHARRAAQLLDEIERHSAALESASARLASLIDEARSEVTAARGVRDSPPDPATGSAIAEAIARVERTLAEVTTNGAADPDAAIARIQATADALDTALAGARNQQQRLTHAREALDGALLTARSQIDTTRAYMVGPRAGAEARTRLAEAERLLALAEAESDPVIALDTARSSATYSRDADALARYDLL
>NZ_CP017146.1|WP_161885587.1|1203034_1203682_-|4'-phosphopantetheinyl-transferase-superfamily-protein
MTGSPASGPHVVVVLRERAMTPAGDRALLVRVVAEATGVTPAEVEVSRRCARCGGDHGRPVLVHCGELGVDGIDLSLSRAGRSVAIAVSFAGPVGIDIESVAAASRAALDDVAFGPAERERLADADASPALRTAMWTAKEAVLKATGDGLRVDPRELEVSFAGRMRGAPRPALVGWPAAPVPIASFQLSALDAGPGLIGTIAVIADARPDIRQGR
>NZ_CP017146.1|WP_161885586.1|1201712_1203038_+|M1-family-metallopeptidase
MPSRSSSYGSASLGDQYLPATGNGGYTVEHYDLDLDYRVATNRLAATAVITARATMRLERFSLDFAGLTVEKVTVDGERPRKTTHTSRKLTVTLDTAVEDGDEFEVTVRYRGAPRPIRGRWGELGWEELTDGVLVASQPNGAASWFPCNDHPSDKATYRISLACESPYTVLANGELASRTARSGRTTWVFDTVEPMATYLATIQIGRYTSRELGTQPVVHTAYFPPDLARVVAVDFERLGDMLALFCDLFGPYPFSSFSVVVTADELEIPLEAQGLAVFGRNHIDGAHGSDRLIAHELAHQWFGNSLTITCWQDIWLHEGFACYSEWLWAEKSGGPTIAASVAEHHRVVDALPQDLVVGDPGPAAMFDDRIYKRGALAVHAVRVQLGDRRFFEALREFVATHRHAGISTTGFVGFFAGCDGDGVIEQLVDRWVFSAPLPPL
>NZ_CP017146.1|WP_161885585.1|1197798_1201707_+|amino-acid-adenylation-domain-containing-protein
MSVTLDNQTVLEAGARVTHARTLVDILAETAVRHPDALALLDADGAVSYRRLVRMVSDRAAQLARSGVHRGDRVGIRIPSGSRELYISILATLVAGAAYVPVDADDPEERAHLVFGEAGVVGVIGADGVLAPHSQEAVRAAPSDAPRPEGIETPTPDHDAWVIFTSGSTGVPKGVAVTHRSAAAFVDAEAGLFLVEEPIGPSDRVLAGLSVAFDASCEEMWLAWRNGACLVPAPRSLVRSGADLGPWLIAHGITVVSTVPTLAALWPEESLELVRLVIFGGEACPPDLADRITVRGREVWNTYGPTEATVVSCGALLGGDGPVRIGLPLDGWDLAVVDPAGARVAEGETGELIIGGVGLARYLDAAMDAVKYAAMPSLGWDRAYRSGDLVRFETEGLVFVGRADDQVKLGGRRIELGEVEAALQGLDGVAGAAAAVQTSASGNHLLVGYLALTEPAVLFDRVAAVERLRAELPSALVPLLAIVDSLPTKTSGKVDRASLPWPLPTTVGEPTDAGLTATAAWLADRWTAILGVPVAGPDDDFFAQGGGSLSAAQLISAIRERFADTRVSDIYDHPRIGSLADELDGRAPHVRATPREVLPTPLSSRIAQTLLGIPLHILAGARWLVYLAAANNLLAAWSQLAFLPQLSWWWIGVGFLLFVTPPGKMALTVVAARLLLRGVAPGDYPRGGSVHLRLWLAEQVALLVNPASAAGAPWISYYARALGARIGVGVDLHTLPPVTGMLSVGHGASVEPEADLSGYWIDGDILRLGHMHIGAESRVGSRSTLLGGASIGRGSEVEPGSAVSGRVPAGERWAGSPAGRVGSAKKSWPAERPPRGTRWLIAYAVGSIAMAAMPASAALLGVVIVGAAIGQAPSPAEAVARAVLATPLATVAAGLAFAFTVIAVVRLLGIGLVDGHFPVRSRIGCQVWMTERILDSARTLLFPLYASLITPFWLRALGAKVGANVEASTVLLIPALTTIAPGAFLADDTMVATYELGGGWLRIGRAKIGRRAFLGNSGMIGPGRTVPRNGLVAVLSATPRKAKRGSSWLGNPPVRLRRTVTDFDEARTFHPPARLRVARALWELLRIVPVIVTALIALGVLVTLDVLWSVLGLGAAVALSGVVMLAAGAVAAGVTTCAKWVFVGRITVSEHPLWSSFIWRNEVADTFVEMVARPWFASAATGTPALAFWLRTLGATVGRGVWCESYWLPEADLVTIADGATVNRGCVVQTHLFHDRVMQLDSVELRAGSTLGPHTVILPAASLDENATVGPASLVMRGERVPGGSLWAGNPIAPWHAPPWNT
>NZ_CP017146.1|WP_161885584.1|1196434_1197103_+|arsenate-reductase-ArsC
MTDAGIGVRRGLPGLTYPEEYLKRLAGELTAKFAGVFSAETVERYVLESYTALLRTSTVTAHLASRTVRFATDRLTALAQAKGSLGVGVPEILFVCEQNAGRSQMAAVLTTHLAGDSVHVRSAGSAPARELNPAVIAVMEELGLDMAKEFPKPLTDDVVQAADVVVTMGCGDACPVYPGKRYLDWGLTDPAGESIETVRGIRDEISARVTAMLGELARDSGA
>NZ_CP017146.1|WP_161885583.1|1196021_1196432_+|arsenate-reductase-ArsC
MSDKPTVLFVCVHNAGRSQMAAGYLKHLSAGAVEVLSAGSEPKDQINPTAVEAMAEDGIDITGNVPKILTTEAVRESDVVITMGCGDTCPIFPGKRYEDWELADPAGQGIDAVRPIRDDIKARIAKLLDELLPARV
>NZ_CP017146.1|WP_161885582.1|1194969_1195938_+|metalloregulator-ArsR/SmtB-family-transcription-factor
MSSLGDSSALSVSLPSPTSLDRDAAEQIARTLKAMADPTRIQLLSLILDSADGRALVGQLADELRLSQPTVSHHVRVMAEEGLLERSQKGRLVWYSVSPDRVDEVSELLNPVSSAPPSPLVLERIAGDLALQFRGIFSGETVDRYVRESYELLAREARIIRYLPSLTGRFAAERLRALATADGLLPHDAPEVLFVCVQNAGRSQLAAAILRSLAGDRVRVRTAGSAPAEAVNPRVVAALDEIGVPLAGEFPKPLTDEVVRAADYVITMGCGDACPVYDGRRYLDWDLDDPSGLALEGVRAVRDEVNRLVRQLLEQMDLPPGR
>NZ_CP017146.1|WP_161885581.1|1193522_1194854_+|NAD(P)-binding-domain-containing-protein
MTLLELSRPVRRTLLVGGLPVAIIGAGPVGLAAAAHLLERGIDFRIYEAGASAASSVASWAHVRLFSPWSLLIDPAARRLLATTDWVQPDADSLPTGAELVERYLAPLAAHEHIASRIHTGSTVEAVSRQGVDRTRSAARSATPFVLRIRTGAELGEVTASAVIDASGTYTSPNGLSSNGFEPLGAEQVVDRIVPALPDVLGSGRARFAGRHTTVVGAGHSAANTLIALAQLAREEPGTRVSWVVRNSGAARVSASPDDALQARASIGARVAALVADGEISLVDRFEIARLRPAVSTTGNGVVIVGVRRGEPFEIATDNIVRATGFRPDLSMLRELRLELDDIVEAPRRLAPMIDPNLHSCGTVEPHGFAELRHPEPNFFIAGMKSYGRAPTFLLSTGYEQVRSIVAWLAGDVAAASAVQLVLPATGVCSTADAGGAEGGCCA
>NZ_CP017146.1|WP_161887370.1|1209737_1210187_-|large-conductance-mechanosensitive-channel-protein-MscL
MKGFKEFILRGNVIDLAVAVVIGAAFTAIVNSLVTGIFNPAIGALFNSESLTTALVLTIPTTSGEPAKLMFGAVIAAAMQFLIVAAVVYFALVLPINHLKKAAFLKQKQEEEATPADLPPTETELLTEIRDLLAGRPSPEGNHSQQTAR
>NZ_CP017146.1|WP_161885591.1|1210197_1210641_-|FmdB-family-transcriptional-regulator
MPTYSYRCTECENAFDIQQAFTDDSLTQCPACNGRLRKVFSAIGVSFTGSGFYRNDSRADQTSAANKSESTGAGKSDAGAAKSDSGSGKSDSGSGSGSGSGSSSSSSGSGSGSSGSGSGSSGSGSGSSGSSGAGSSSSAKASASVAK
>NZ_CP017146.1|WP_161885592.1|1210670_1211249_-|5-formyltetrahydrofolate-cyclo-ligase
MTGDASHQKRALRVELRERRRQLTDRDRDTAAAALTAHLVELATHLRATSIAAYLPTTDEPNIRPFVEWAIGSGIRVLVPISRDDGLLDWAVTDGRQETEGLYGMPEPVGELLGPIAINDVDLIVVPAAAVDRSGMRMGWGRGYFDRTLGSMERCPPVYAVVFDTELVDSVPIEVHDKSVDGVITPSAIVTF
>NZ_CP017146.1|WP_161885593.1|1211316_1212207_+|UTP--glucose-1-phosphate-uridylyltransferase-GalU
MAFEITKAVIPAAGLGTRFLPATKAMPKEMLPVVDKPAIQYVVEEAVGAGLRDVLMITGRNKNALENHFDRVGELEATLERKGDTDRLQKVNYSTDLADMHYVRQGDPKGLGHAVLRAKMHVGRESFAVLLGDDIIDPRDVLLTRMIEESGKRNASIVALLEVDPSLAHMYGVATIEETETEDVVRITGLVEKPAPGTAPSNYAIIGRYVLRPEIFEILEETPPGKGGEIQLTDALETMAAAPATGGVYGVVFRGRRYDTGDRLDYIKAIVQLAVEREDLGPDLRPWLKDFAGNLD
>NZ_CP017146.1|WP_161885594.1|1212211_1212874_+|GNAT-family-N-acetyltransferase
MATPIPTLREGAVTIRPIRLRDARALERELLDNRGWLRKWEATNPHGPMSFDTRASIRGLQANGRAGLGLPFAIEYDGEFAGQLNVSSITYGSLGSATIGYWVSERFAGKGVTPTAVALATDFCFFRAGLHRMEICIRPENVPSLRVVEKLGFRYEGLRRRYIHINGDWRDHFCFALVVEELPTGVLRRWLDGRVPAANAVIPESDRNAAGVPLRLGASG
>NZ_CP017146.1|WP_161885595.1|1212926_1213850_+|hypothetical-protein
MGLEGIGSSVVIALAAVLWLVYLIPTWFRRREYLSTERNAVRLQQTLRILAETAEVPESVRAEATARSVAAQQKLLRQEFERARATERARESAMSRAAAQTPATLAPAVASTLAPTSPAAKRLRRSRAATTALLALSLATVGLGFAPVAAGVSTTLIASGLLAATASVLLLRAMAAVARDRRRRAFTLIDRPASSRLVDFSLEQNASTPVSDPAWTPVPVPKPLYLSKPRTQSVASAAAIAETRTRLLAEAEKTERAARAAELSEKVIPIVRPAAAPESRFARMGIVDETPSAITNLDEALRRRRAV
>NZ_CP017146.1|WP_161887371.1|1214103_1214739_-|ion-transporter
MGILGLLFLFVVLGQLVATQEALVTALTILGWVFWLVFVAEFLLRAYVARFQLKFWKKSWWQVIFLLVPFLRFFRSLQALRLFRLSRVGRLGAILSASVRGTRSAGRLMTSRIAWLVAVTAVVALGSSQLLYATGAYDSYSDALFEAALTTVTGSGITSTDGFPRVLHITLATYSVAVFATLAGTLGAFFLRGTPSEAEPRTSTSASTSTR
>NZ_CP017146.1|WP_161885596.1|1214815_1215328_-|DUF421-domain-containing-protein
MWFDSWSDIFRTLIIGSASYLTLVLVLRASGKRTLSQLNAFDFVVTVALGSTFATILLSTDVTWAEGFAALGLLASMQFLVAFVSSRWQGARALVTSEPVTLLREGALQTAEMRKNRLSESEILQAVRSSGCGDLAQVATVVLETNGTLTVITTDRYGDGSAMKGVVNNR
>NZ_CP017146.1|WP_161885597.1|1215482_1216859_+|DUF2254-domain-containing-protein
MASSTPRRAGGRRITESLRAQLWPVPSIAIAFAIAIGIALPILDEAIDDNLPVWLTVYLFQGGADASRAVLQAIAGSLITVTALTFSLTVVTIQLASSQFSPRLLRTFTSDSVVHATLGLLLGTFVFSLTVLRTVRTGDDERDVFIPLMSTTLAYVLAVASVIGLVVFLAHLVRELRIETMLSTVHAETFAELERSFPDGPGETVIVPTGGRSTEILVDAAKSGFLLTVDEHSLLDLATAHSVVIRIDALPGASLVRGVPLATLWPQKPGTEIAEDDLAELRSSVAAAVSSGSERTIVQDAGFGLRQLIDVAVKALSPGINDPTTAVHTLGHAAALLCDLAARDLGPRLLRDESELVCVIVHRPTFAHYLDLVIAQPRLYGIADAAVTARLLRLLQEVAWNGEVPAVRAAVRDQLARMRESMARQEWIEADRSRLNALATEVDDALDGRWRAEAHGAD
>NZ_CP017146.1|WP_161885598.1|1217045_1218032_-|M56-family-metallopeptidase
MIAAAVALAALAVVLAWPVPVALARTAWPSRAPATALALWQAIALAGGLSMIGALLTFGLAPFGNTLLDATLAAVAGAAGSKRGPGLEPGGSTLWPPPISNLLALVVAGLLAAYLVANLLRTALLIERERRRHRQLVRLLSTPVPDHPNTRLINVELPVAYCLPGSPHPITVFSAGLVQLLDDVQLRAVIQHEKAHLLQHHYIVLMAFDAWHRSLPWFPTASRARTEVALLIEMLADDHARRTVDGRTLAGAIALVASGAAGGSENGTASAIDTDLASHHAHQQRARVTRLIGDAPGLSRPRQTLVLAGAIALVAVPTVLLLTPALAG

Crispr_ID: NZ_CP017146_11

• CRISPR_ID: NZ_CP017146_11
• CRISPR_location: 1795070-1795184
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP017146_11

Consensus_repeat	Method
CGGATTCTTGGGGCGCTCGGATGCTT	CRISPRCasFinder

spacers of NZ_CP017146_11

>11.1|1795096|63|NZ_CP017146|CRISPRCasFinder
GGAGCGGCTCGGATTCTTGGGGCGCTCGGATGCTTTCGGCGGCCCTGATTCTTGGGGCGGCCC

CRISPR arrays and Neighbor proteins around NZ_CP017146_11

CRISPR arrays

The CRISPR arrays of NZ_CP017146_11

>merge|NZ_CP017146|11|1795070-1795184|CRISPRCasFinder
CGGTTGGTGGGCAGGCTCGGATGCGTGGAGCGGCTCGGATTCTTGGGGCGCTCGGATGCTTTCGGCGGCCCTGATTCTTGGGGCGGCCCGGATTCTTGGGGCGGCTCGGATGCTT

>NZ_CP017146|11|10|1795070-1795184|CRISPRCasFinder
CGGTTGGTGGGCAGGCTCGGATGCGT	GGAGCGGCTCGGATTCTTGGGGCGCTCGGATGCTTTCGGCGGCCCTGATTCTTGGGGCGGCCC
GGATTCTTGGGGCGGCTCGGATGCTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017146.1|WP_161886051.1|1791994_1794943_+|hypothetical-protein	unknown	unknown	gnl|CDD|274858
NZ_CP017146.1|WP_161886047.1|1780297_1786156_+|tandem-95-repeat-protein	unknown	unknown	gnl|CDD|333740
NZ_CP017146.1|WP_161886043.1|1775776_1777213_+|gamma-aminobutyraldehyde-dehydrogenase	unknown	unknown	gnl|CDD|143411
NZ_CP017146.1|WP_161886050.1|1790951_1791761_+|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl|CDD|372305
NZ_CP017146.1|WP_161886057.1|1803993_1805340_-|4-aminobutyrate--2-oxoglutarate-transaminase	unknown	unknown	gnl|CDD|235685
NZ_CP017146.1|WP_161886049.1|1788639_1790940_+|transglutaminase-domain-containing-protein	unknown	unknown	gnl|CDD|376628
NZ_CP017146.1|WP_161886052.1|1795705_1796914_+|spermidine/putrescine-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270308
NZ_CP017146.1|WP_161886044.1|1777240_1777822_+|FHA-domain-containing-protein	unknown	unknown	gnl|CDD|238017
NZ_CP017146.1|WP_161886046.1|1778812_1780249_+|serine/threonine-protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_CP017146.1|WP_161886045.1|1777818_1778655_+|serine/threonine-protein-phosphatase	unknown	unknown	gnl|CDD|223704
NZ_CP017146.1|WP_161886053.1|1796913_1798113_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|226361
NZ_CP017146.1|WP_161886048.1|1786235_1787207_+|MoxR-family-ATPase	unknown	unknown	gnl|CDD|223786
NZ_CP017146.1|WP_161886054.1|1798115_1799027_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|224097
NZ_CP017146.1|WP_161887439.1|1787374_1788643_+|DUF58-domain-containing-protein	unknown	unknown	gnl|CDD|224635
NZ_CP017146.1|WP_161886058.1|1805377_1805872_+|OsmC-family-peroxiredoxin	unknown	unknown	gnl|CDD|224678
NZ_CP017146.1|WP_161887252.1|1801472_1802708_-|IS110-family-transposase	unknown	unknown	gnl|CDD|376564
NZ_CP017146.1|WP_161886059.1|1805799_1806945_+|peptidylprolyl-isomerase	unknown	unknown	gnl|CDD|223619
NZ_CP017146.1|WP_161887440.1|1799044_1799896_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|224098
NZ_CP017146.1|WP_161886055.1|1799892_1801266_+|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|235917
NZ_CP017146.1|WP_161886056.1|1802947_1803997_-|asparaginase	unknown	unknown	gnl|CDD|377601

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP017146.1|WP_161886051.1|1791994_1794943_+|hypothetical-protein	gnl|CDD|274858	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa. This model represents the N-terminal domain or EccCa subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	1.76112e-56
NZ_CP017146.1|WP_161886047.1|1780297_1786156_+|tandem-95-repeat-protein	gnl|CDD|333740	NF012211, tand_rpt_95, tandem-95 repeat protein. This 95-amino acid repeat occurs in tandem in proteins that may be several thousand amino acids long.	2.73064e-07
NZ_CP017146.1|WP_161886043.1|1775776_1777213_+|gamma-aminobutyraldehyde-dehydrogenase	gnl|CDD|143411	cd07092, ALDH_ABALDH-YdcW, Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like. NAD+-dependent, tetrameric, gamma-aminobutyraldehyde dehydrogenase (ABALDH), YdcW of Escherichia coli K12, catalyzes the oxidation of gamma-aminobutyraldehyde to gamma-aminobutyric acid. ABALDH can also oxidize n-alkyl medium-chain aldehydes, but with a lower catalytic efficiency.	0
NZ_CP017146.1|WP_161886050.1|1790951_1791761_+|zinc-ribbon-domain-containing-protein	gnl|CDD|372305	pfam12773, DZR, Double zinc ribbon. This family consists of a pair of zinc ribbon domains.	4.457e-06
NZ_CP017146.1|WP_161886057.1|1803993_1805340_-|4-aminobutyrate--2-oxoglutarate-transaminase	gnl|CDD|235685	PRK06058, PRK06058, 4-aminobutyrate--2-oxoglutarate transaminase.	0
NZ_CP017146.1|WP_161886049.1|1788639_1790940_+|transglutaminase-domain-containing-protein	gnl|CDD|376628	pfam01841, Transglut_core, Transglutaminase-like superfamily. This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.	2.13376e-11
NZ_CP017146.1|WP_161886052.1|1795705_1796914_+|spermidine/putrescine-ABC-transporter-substrate-binding-protein	gnl|CDD|270308	cd13590, PBP2_PotD_PotF_like, The periplasmic-binding component of ABC transporters involved in uptake of polyamines; possess the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding domain that functions as the primary high-affinity receptors of ABC-type polyamine transport systems. Polyamine transport plays an essential role in the regulation of intracellular polyamine levels which are known to be elevated in rapidly proliferating cells and tumors. Natural polyamines are putrescine, spermindine, and spermine. They are polycations that play multiple roles in cell growth, survival and proliferation, and plant stress and disease resistance. They can interact with negatively charged molecules, such as nucleic acids, to modulate their functions. Members of this family belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	5.95366e-89
NZ_CP017146.1|WP_161886044.1|1777240_1777822_+|FHA-domain-containing-protein	gnl|CDD|238017	cd00060, FHA, Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).	0.00130131
NZ_CP017146.1|WP_161886046.1|1778812_1780249_+|serine/threonine-protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.00328e-71
NZ_CP017146.1|WP_161886045.1|1777818_1778655_+|serine/threonine-protein-phosphatase	gnl|CDD|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	3.02587e-58
NZ_CP017146.1|WP_161886053.1|1796913_1798113_+|ABC-transporter-ATP-binding-protein	gnl|CDD|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	1.37765e-146
NZ_CP017146.1|WP_161886048.1|1786235_1787207_+|MoxR-family-ATPase	gnl|CDD|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	1.81496e-91
NZ_CP017146.1|WP_161886054.1|1798115_1799027_+|ABC-transporter-permease	gnl|CDD|224097	COG1176, PotB, ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism].	1.22871e-64
NZ_CP017146.1|WP_161887439.1|1787374_1788643_+|DUF58-domain-containing-protein	gnl|CDD|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	3.17771e-25
NZ_CP017146.1|WP_161886058.1|1805377_1805872_+|OsmC-family-peroxiredoxin	gnl|CDD|224678	COG1764, osmC, Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism].	4.74818e-18
NZ_CP017146.1|WP_161887252.1|1801472_1802708_-|IS110-family-transposase	gnl|CDD|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	1.22892e-23
NZ_CP017146.1|WP_161886059.1|1805799_1806945_+|peptidylprolyl-isomerase	gnl|CDD|223619	COG0545, FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones].	4.07661e-26
NZ_CP017146.1|WP_161887440.1|1799044_1799896_+|ABC-transporter-permease	gnl|CDD|224098	COG1177, PotC, ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism].	3.08229e-68
NZ_CP017146.1|WP_161886055.1|1799892_1801266_+|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	gnl|CDD|235917	PRK07046, PRK07046, aminotransferase; Validated.	0
NZ_CP017146.1|WP_161886056.1|1802947_1803997_-|asparaginase	gnl|CDD|377601	pfam06089, Asparaginase_II, L-asparaginase II. This family consists of several bacterial L-asparaginase II proteins. L-asparaginase (EC:3.5.1.1) catalyzes the hydrolysis of L-asparagine to L-aspartate and ammonium. Rhizobium etli possesses two asparaginases: asparaginase I, which is thermostable and constitutive, and asparaginase II, which is thermolabile, induced by asparagine and repressed by the carbon source.	2.9556e-112

Protein sequences

>NZ_CP017146.1|WP_161886051.1|1791994_1794943_+|hypothetical-protein
MIATLVPVAVSGLIWTVTQSPFALIFALLGPVVAIASLADSRVQRHRRRRAELRRFEAELAETFGAIVAGHEAERAELDLRYPGVHALLRQSAEAEGWTVADRWAGRDGWGGWDGRARRDAHTGLAGPAGRALPVTLGRGRVRSTLPLEGDPPPAGVADSRVAASLREARAAAAVLEDAPVVVDARLGIGVCGPRAAAAAAARAVIVQLASTLSPMTATICSDASSRGWAGALPHRLEPGAGALPPAQAFEFVLRGAELADDMRDGRPEVITVGLAGRAGDLPRQCGVIVTVGTGGTASARLRGPRGEEGDVLVDFASEREAALFAHALRRRAHLQGLSVGELPERVLLAGLEQPDAGGEGLRCAVGRAGAEPWFLDLVADGPHAVIGGTTGSGKSELLISWVLSMAAAHPPSTVTFLLVDFKGGASFNAISSLPHSVGVITDLDAGAAHRALESLRAELLFRERTLTSAGARSIEELEPPGLPRLVIVVDEFAALASEFPELHRLFADLASRGRSLGIHLVLCTQRPAEALRDSILANCTLRIALRLNNRADSSAVIGTGAAADLPRQPLGRALASVAGEKPRTVHVAISDAADAARISALWPGDGRVRRPWCDPLPLLVPHAELAAAVSPDGGVNRDGGQGLDGFVFGISDLPQEQRRTLATYRPLIHGNLLVCGAQSAGKSMVLDAIVAGGPGGATQLIPRDIEGAWDELMALCASLATGALTPRVVLLDDVDSLFARFGQDHQLGFADMLAGLLRDGPRHGTTTVIATQQLPTALHSVTALCGSRLLLRLPSRHDHLLAGGRGDQYDEHLPPGGGVWESNRMQVGHLPPRRPLPAPVPPTLDLRPGAATAVVSASPRDLARRVAGVRGIRIVDIGAADVAQLADVERLADAAQLADAAQLADAAVHTILLGNAQAWQGAWTTLAAVRGRIPLVFDGCTVGDFRGVTGSRRLPPPLAPASRSLWLLTAGDTLERTTLPG
>NZ_CP017146.1|WP_161886050.1|1790951_1791761_+|zinc-ribbon-domain-containing-protein
MKCPNCSQSLPAQALFCGACGQAVAPPVLAPAQLRPLVDPPEVVRPETVTAEPVGVTEHIACDECGAVMSVSDIFCGDCGRVSSTVSAAFSSARDTDSVTESILSTSPEHPVDGAAAPRLRGPESTIDSRTVRAPAPAPAPSAAGDAHDAQSTGIASAGAQGERFVLQFSTGESVTVSGTGLVGRNPVSEPGEYFDDLVRVLDSTRSVSKTHLEFGQQAGVFWVADRYSGNGTIVREPDRPGIRCEPGKRQIVSRGGRVVIGEQFFVVS
>NZ_CP017146.1|WP_161886049.1|1788639_1790940_+|transglutaminase-domain-containing-protein
MKRRRPTVKFTVATTAMMWLTTAIAATALWPIYESGAFLLMLGVTTVVASALAITGAVFRFPAHLVALSGVLAYVVLGVPLAVPGEARYGVLPALPGLADLGFGTIAGWKQLLTITLPVGSYESLLVPAFVLVLGTVLVGLSVALRTRVPERAVIAPVILFITGILLGSTTAFVPVASALALTATLLLWLIFFRWYRRRTTSRRYGGAGDAGEASTRVSEDAIFVGARSVLAAALIIAIAAGGAVAATAFVPPAGDREVLRSAIVQPFDPRDYPSPLSGFRRYHQETNVDATMLTVDGLPEGARIRIATLDTYDGVVYSVGAEGRNSDSGSFTLLPSRFDRSSLDGTRVSVDVSVDGYSGLWLPTVGALESIRFTGQGASGLRGSFYFNDNSRSAAVLGELGAGDGYRLSSVLPVEPTPEALTRVTPGASQLPALPVLPEELTVALDRYSGQIQGLGARLSAAMTGIRAEGYISHGVADDEPTSRSGHSADRIAELFSGQQMIGDEEQYAVAAALMAREIGFPARVVVGFAPADAVPDGTTVVTGADISAWIEVDTAEYGWVTIDPTPPKREIPERAPEEPTQVARPQSPVQPPALDRDVPEDQLAPETAQDEGDTADPLLALVLLVLQVSAWTLLGIAILLSPFLAIMGAKLRRRHLRRSALSPLDRISGGWHEFADAVVDHGYAPPGGATRAEYAETVGGVEPLLLAAAADRAVFGPSDPSATEAKQVWRSVEVLRHSLDRGLTRRQRLRARISLRSLGGKRTT
>NZ_CP017146.1|WP_161887439.1|1787374_1788643_+|DUF58-domain-containing-protein
MLADIVVALVRAGRAILGLVRVVAIRIGAVVTPLGWSTAVVVPLAFLFGYRFGWLELVAVAYAGVVLLAIAVLYLVGRVAFDVELVVPHRHLVVGQPGTGVVSLRNPTRHRVFGTRVEVPVGRKLIDLVTPSLAAGEQSRHEFTLPTSRRGVLDIGPVRGVRADPVGMVRRELVWTGTTQLFVHPRTIDVPSTSTGLIRDLEGKPTRDLTNSDVSFHALREYVAGDERRYIHWKSTAKTGTYMVRQFEETRRSRLVVALSLAESDFANDAEFEMAVSAAGSLGLRAIRDAREVSVVVGEVTPEFAKRKVLGIRQLGSLSRTRLLDDLAGVERAESSLPIVDVARVTSEKLAGISVAFLVCGSLTTPTQLRAASVLFPVGVEVVAVVCDPDAVPGFRRFAGLSVLTIGYLEDLGRSLARSASV
>NZ_CP017146.1|WP_161886048.1|1786235_1787207_+|MoxR-family-ATPase
MTMTPEQAGWFSATFNRLVGNVEQVILGKTFVVRLSFVALLSEGHLLLEDFPGTGKTSLARAIAQSVAGVSSRIQFTPDLLPGDITGVSIYDQRSGRFDFHRGPIFANIVLADEINRASPKTQSALLEVMEEGHVTVDGTTHGVGSPFMVIATQNPIEQAGTYRLPEAQLDRFIMKASIGYPDHSSTVRILEGAGTKAHETTVPAVVSASTIVEMAALARTVHVDPSINDYISRLVDASRSAVEVRLGVSVRGALALVRASKTLAAASGRHYVIPDDVKLLAEPVLAHRLILDAEAEFDGVTALSIIGQLLIETPPPSDRQAV
>NZ_CP017146.1|WP_161886047.1|1780297_1786156_+|tandem-95-repeat-protein
MTATSASLIAAVVAGLAVVSGGYEAQRIDLGDGSVWVANSAEQVIGRANTEILALDTVVEGSGSELDVIQAGRTVLLFDRANSKVDIVDAATAEVSDSVPLPPEAPELHLAGGTVVIHATRTGAVWLVPVGDLRDFDAEAEPTLSLGTDSAVSVSPDGTLLLYSPDAGEVYRVNSATGDSVEEAYPVDFAEPGSEISVSSVAGRWVLFDANSSRISIEGRMLDLSELLDGARNAVLQSPSDTGDSVLLGFPGGLLSVPLTEGAPSVVASSTGGTPAAPLVLGDCVFAAWTSGVAWRDCAGDTAPSELSLESVGGSAARLAFAVNGARVVLNDPRSGSSWAVQQRGELIDNWDELIVDDEQRQEVEENNDDVPPEYEPDQLPPIAIDDEFGARAGRANVLSVLLNDYDPNGDVLVVETVDPVEESIGRVDVIDSRQRIQLTLLDDVTGTVSFDYTVSDGRGGTAAATVTVTVRSPGENSPPVQVRTTRAVVAEGNRVTTPVLGDWIDPDSDAFYLTAAATTPPDVVTYKPSGTVDFQEGGAASQLRAVSLAVSDGEAIGAGSLTVSVRPAGEVPIIADPFVVLSYAGQETTVRPLEHVRGGTGELRLSSVAPRPGVTIEASLDTGTFRFASDQVRSHNLEYVVNDGDQTVTGTVRIEVQARPDANSTPITIPKTVFVKTLSSETVDVASTDIDPAGGVLLVTGVSNVPDGSGVSADVLEQRYVRVTLTTPLEGTVAFDYRVTNGLAGADGVITVVEIPRPTTLQPPVAADDTVTVRMGDSVDIPVLDNDAHPDGEQLTLNPDLPSGLRSVSGFLFASGDVLRYLAPQRSGNFTAVYEVAGPDGQVDQAEVRIAVREPVAATNSAPVPVSVTSRVLAGETVRIKIPLTGIDPDGDSVQLLGQETSPQKGAVTEVGTDYIDYLAGEYSAGTDTFTYRVIDSLGKRAIGTVRVGISPRSGDAGNPIAVEDEVLIRPGKTVSVQVLANDSDPDGSPLTILSVEPNSPEIGYEIVDDIVTVTPPADPGRYGLVYTIENAYGGTSSNFITVVVDPDAPPAYPVARDTVLTLSDIVDRDTINVDVLRNVFFADGDVSSLELSVLTGYGDTASVVRGKRLNITITDTRQIIPFSVANPDDPTIVAYAFVWVPGFNDALPQLDRTAPTLTAVSESRIEFDLNDHVLAVAGRDVRLVDSTTVQATNANGDSLVVDEDTLAFTSADGYFGPASISFEVTDGTSVDDPNGRRATLVLPISVTPRENQPPVFTGATIDFEPGEEKTLDLLRLTTYPYPDDIDELTYSAGPTPPSGFDYEIRGTNLIIRANEGSQKGTSSGLTIGVRDDLAAGQAGRIQLSVVASTRPLAKPAADSIIVERGTTASLDVLANDQATNPFPGGELTVVAITGLDGSALPAGVTVTPNAARTRLSVTVSETAAPIDTNLQYQIADATRDPSRYAFGSITISVQDRPDTPVAPARADGGYEEGLLTLRLTAPPSNNSPIVKYEVVSTSHGSYRKDCGTALRCELTDLDAGLRYRFSVIATNSIGASAAGPQSAALSADYLPAAPRSVTARAKAAEARPALDVAWSTVPNPALGTPVSGYVVRISGPGVDFQTTTGPTTASLTTTASGALVPGSQYSVTVYARNAAEVLSDADWRRTSSAAVTVIGPPSQVSVAADVVNGTAGQIRVTWGAGGPNGAPGVVYSVGRFDAAATIPSTCAPGGANPGVASGASPPASSGWIDDRATDGVDYRYVVYVDNGLFCTPSASGSVQSKAPPGAALASTVVEQRDGKFDLRVGSLSVSSGIVSRFQAQLNGSGTWFNVAEGDWLTSAGNLGVYGAPQSVVYRACRDSSDFFCGVASTGEVLTPVNARGSIVSCEAGATPTSNPPANQGSPTYRYLYAYNDGGPPLDRWSEFEQDAVAPDPAAVGSGETGVRLKVVVSLPDGSTFTDDGYVQSTCSPRP
>NZ_CP017146.1|WP_161886046.1|1778812_1780249_+|serine/threonine-protein-kinase
MARRLPSLPPVLPGFAHVHVLGSGGFADVFLYEQNMPRRQVAVKVMLSEVVNEQVRHMFQAEANLMAQLSAHPSILTVYQASVSSDGRPYLVMEFCSSGLSDRYRRERIPVPEILRIAVKIGSAIETAHRAGVLHRDIKPSNILLTAYGHPVLSDFGIASTLGEAENHDAVGMSIPWSAPEVLDDETPGTIESEVWSFAATVYTLLAGRSPFEVPGDSNKSTDLMARISRAKVQPIGRPDVPASLERVLQRGMSRRPESRQGTILELVREIQAVETELGVLQTPIEVAVDDWALSSMSDLEERTRVRGVAGAPSSTAARRRRRRSSAAEPASEYAAVGTILRSSSSQIARSTGTIPLATRRAFRWVAISLVAAAVLVIGLGAIVTTSLVRANAGAIPVVVDIDAQATTDSVEFSWPDPGLLPSDSYQISATDRQSIIQTRREFSITASDGDRVCITVTVNRDGKTGASSIEKCVVFES
>NZ_CP017146.1|WP_161886045.1|1777818_1778655_+|serine/threonine-protein-phosphatase
MTQIGRSTARRSLSIPGEHGQSVALSWAAATDIGRKRALNEDSFLAEAPFFVVADGMGGHASGDVASAAVVQRLAQEGSADFVEPEQIMTALRVATADITLAADDDDLGVGTTATGAVLTLVDGAPYWAVFNIGDSRVYQLADGELTQVTVDHSVVQELVDAGLLPQDQAEFHPDANIITRAVGFNAEPMADLWMLPVRTGLRLLICSDGLTREVSDVVLRQMLGAGLGPQETATTLVDAALAAGGRDNITLVIVDVVESPDTAPLENTLPRRDAATA
>NZ_CP017146.1|WP_161886044.1|1777240_1777822_+|FHA-domain-containing-protein
MDNDDLADTVIRPSRPPVEPSARPHEDTIVKAPPPLVLPSDRRASKRSRERAVEDITAQPELSAPARYRFSLNSAEPIPLDVPVLIGRDPRPPRVATAVTPRFVRVNSPRREVSATHVELRQDGASVIVTDMRSTNGTVITVPGMPEFTLHAGGSMVLAPGTTIDVGDDNIVEIMPIGRLLARDHEPFERLSP
>NZ_CP017146.1|WP_161886043.1|1775776_1777213_+|gamma-aminobutyraldehyde-dehydrogenase
MTASELRNFIGGQYVEAKASSAFDVIDPATEMSYTSSPVSGREDVDTAYASASAAFEEWGESTPSQRQLALFRIADAMESRAEEFADLESQDTGKPRGSLVEDEIMLSVDQIRFFAGQARSLEGKSAGEYMTDHTSFIRREPIGVIGQVTPWNYPLNMAVWKFAPAVAAGNTTVLKPSDTTPQSTLLLAEIAAEFLPPGVFNVITGDRTTGAAMIEHAIPQMVSITGSVRAGMEVAKSAANDLKRVHLELGGKAPVVVFNDADIEKAVEGIGVAGYFNAGQDCTAATRVLVHEDIHDEFVAALVAWAKDNAKTGAPSADDILFGPLNNSSQFNRISSVVDALPTNANVELGGRRQGDRGYFFEASIVTGLMQTDDAIQNEIFGPVITVQKFTDEVQALAWANDVQYGLASSVWTKDHGRAMRFAKHLDFGCVWINTHIPIVAEMPHGGFKHSGYGKDLSAYGFEDYTRIKHVMSYIGH
>NZ_CP017146.1|WP_161886052.1|1795705_1796914_+|spermidine/putrescine-ABC-transporter-substrate-binding-protein
MTRPLPKDPMIQQLIAQARRSQLSRRTLMSGAGLGAAALTLAACATGDGEAPAPAEDNSANDKTLNWDNWAAYIDEDDDGNYPTLVAFEEETGIKVNYSVAVDDNNSYYGKVKDQLALGQDIGADLVCLTDWMVGRLIRFGYVQEFDQANLPNAKNLTPSLQNPDFDPGRTLSLPWQGGFAGICWNKEKVPGGLESVADLWKAELKGRVGVLSEMRDTIGLIMLDNGVDISADWSDDEFNAAMEIFEKQVNDGQIRNIKGNSYLEDLKNEDTLAAICWSGDITVINAEAGDKWEFAIPSAGATLWNDNFVVPIGSGRKANAEALMNYYYQPEVAAEVAAWVNYITPVVGAKEAAMAIDPELAENQLIFPNEDTLSNAYIFRTLSGAEESTYGSAFQAVVLGS
>NZ_CP017146.1|WP_161886053.1|1796913_1798113_+|ABC-transporter-ATP-binding-protein
MAAGGFAEAGADLELVGIEKRFPGFTAIEELNLTIPAGSFFALLGPSGCGKTTTLRLVAGLEEATAGRILIGGNDVTSTKAYQRPVNTVFQSYALFPHMSIIDNVAFGLRRRKIDDATGKAHEALRLVELDHLAARKPSQLSGGQQQRVALARAIVNRPALLLLDEPLGALDLKLRRQMQLELKSVQEEVGLTFLHVTHDQEEAMTMADTVAVMNKGRIEQLGAPAVLYELPRTVFVANFLGQSNLFSGQVVAENPDSISVDIEGNRILVPKARAHRTSGHVTVGVRPEKLILSREAPTESVDTNILGPGRVIDVSFSGVSTQYLIQIPLIGTIVLFAQNMGTGPIVGEGAEVWVSWNVEHGFGLDDEVETGSRFPADTDTASLARQKRHALLSELGED
>NZ_CP017146.1|WP_161886054.1|1798115_1799027_+|ABC-transporter-permease
MAFSAFATATAAEQAPRRASKVALLLLLPGIAYLMLFFLVPLFSLVITSLQAPAEFGDIGEYDNAFRWENYTTVIGQYSAQILRSFLYAVLATVFALLFSYPLAYFIGVRARPYPLLQKLILVMVIAPFFISFLLRTLAWKQILSDESPVVAALKALSLLAPDAYLTGTPFAVVFGLTYNFIPFMTLPLYASLERLDTRYLEAGSDLYSTPFTTFRTVTIPLSMPGIVSGVLLTFIPAAGDYVNASREFLGGTGTTMIGNVIESNFLISLNYPAAASLSIILMAVILVLVTAYVRRSGTEDLL
>NZ_CP017146.1|WP_161887440.1|1799044_1799896_+|ABC-transporter-permease
MLAEAVTTPQPRKPRQRPSFALGKWLLPLYTTLALLFLLIPIAYTFVFSFNDSVKSNISWRGFTLDNWTGVCNAQDVCEAFGNSILIAFVATVVATTLGTMIAIALVRYRFRFRSGISLLLFLPMATPEVVLGAGLAAQFLGAGVQKGLGTIIIAHTMFCISFVVVTVKARVSSIDPALEEAGRDLYGSPAQVFWRITFPLLLPGIVAAALLSFALSFDDFIITNFNSGAATTFPKFVYVAASRGIPAEANVIASAVFVFAITLVITTQVTSTLRARRMAAKS
>NZ_CP017146.1|WP_161886055.1|1799892_1801266_+|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme
MTAEPNAPYPHRRRLAELWEVEVQRFRAARPQSDLLFRQAKEHMADGVPMLWMAKWPGPWPVYVDVAQGAHFRCVDGIDHVDLCLGDTGAMCGHAPPASVAAITHQLSRGSTLMLPTADAAAAASMLAERFGVPSWQFALSATDANRSLIRYTRQVTGRRRIAVHDYCYHGTVDEAYATLDENGAVVSRRGNIGPPVPLDETTAVVPFNDIPALEEAFAAGDIAAFLIEPALTNIGIVLPDPGYHAAVRELCTRFGVVLIIDETHTFSAGPGGMIRADALEPDAVVIGKSIGGGIPAGAYGMTTEFAAAVRASLDLEDIDVGGVGGTLAGNAVSLAAIRATLGEVLTADAFAGMIERCTQWTAGVQAALDEFEVPWQVTQLGARAEYSFRATAPTTGSEAAHADDFELQQYLHLHALNRGILITPFHNMALMSPVTSAADVERHTVAFREAVESLYA
>NZ_CP017146.1|WP_161887252.1|1801472_1802708_-|IS110-family-transposase
MDVVHERAAGMDISKRDVKVCVRVPGKRPGTFEQKVTTWGATTSQVLELREHLLANRVTTVVMEATGDYWKPFYYLLESVLPVTLVNARDVRNFPGRKTDVSDAGWLAQLAAHGLVRASFVPPEPIRELRDLTRTRATIVQERSRHIQRIEKILEDAGIKLSSVVSQLNGVSARSILDALVAGERDPVKLAALAKGRLRAKIPELVEALTGRFRDHHAFMVNLHLTQLDHSATLIDEITARIEVVMEPFRVFRETLTTIPGVSVRVADVIIAETGGNMHIFPSPGHLASWAGVCPGSNESAGRVKSTKTRPGNAHLKAALGISALVITRQKNTHLAVKYRRIAARRGSIKAIVALEHSILVAVWKMGTTGEAFTELGPNYYSNRHPDRTKSNAINQLRTLGYQVTLTPTAA
>NZ_CP017146.1|WP_161886056.1|1802947_1803997_-|asparaginase
MTSFPPLLTRRPLDLDGSVELAVLERAGLIESRHIGAAVVVAPDGSVLRELGDSSAEIYARSSLKLLQAVAVLRSGATLDGERAVLATASHAGTDGHVRVVSEILALAGLTEDDLRCPADWPLDREAAYSARRRGDGKRRITMNCSGKHASFLLACVVNDWPTASYLDPSHPLQQLVRTTIEELTGEGVGTVGIDGCGAPVFGTSLRGLASAVGRISGAARAGGDPLAARLAAAILVDGWAIDGPGRATTVVIERLGLVAKNGAEGVMVLGAPDGTAVAVKALDGSNRATTLVALELLVSVGALDRALADAVIADTTERVLGGGVAVGELRASLSLFSVSGALPLRGGC
>NZ_CP017146.1|WP_161886057.1|1803993_1805340_-|4-aminobutyrate--2-oxoglutarate-transaminase
MTDILSARADAPVSQQRRILTAIPGPKSTELQKRRLASVPSGVGSALPVYVERAHGAIVVDVDGNQFIDLGSGIGVMTIGHTNAAVVAAATAQLAEFTHAMFTITPYENYVRVAELLAEHTPGAHAKKTMLINSGAEAVENAVKIARKHTGRNGVAVLDHAYHGRTNLTMAMTFKAMPYKSGFGPFASDVHHAPNSYPFRDGLSGPDAAARTISYLEKKVGASDLACLVVEPIQGEGGFVVPADGYLPALQEWCNANGIVFIADEIQSGMARTGAWFASEHFGIVPDMLLSAKGIAGGLPIAGVTGRAEIMDSPHAGGLGGTFGGNPVAAAAAVAVFDEIESRGLLAEGARIEGILKPGLLELKSRYDVIGDVRGIGAMLAIELVRPGTLDPNPAAVSAIATFAAQHGVIILTAGTLGNVLRFLPSLAISDELLREALEVLGDAFASL
>NZ_CP017146.1|WP_161886058.1|1805377_1805872_+|OsmC-family-peroxiredoxin
MNSEHHYSVRIQWQGNRGSGTSDYRSYSRQHVIEADGKHDISGSADRVFHGDRDRWNPEELLVAALAQCHMLSYLHVAASHGVVVTDYTDSPVGTMVQTPGGGGHFTLVVLHPVVTVSAPPGDDEAIVELAAALHGEAERKCFIAASMGFPVHHAVTTIVTPSA
>NZ_CP017146.1|WP_161886059.1|1805799_1806945_+|peptidylprolyl-isomerase
MLHCGIHGIPCASRGDDHRHPFCLIRRVPSIAGPLRLRRDRCDTLAPAPLPPPESRLLSKKLLTSLTIATVVFSLVGCSTGTNEADAPNCAATESGESSEKVNVSGDVGSAPKVEFDSPLNAETTERTVVDEGDGDVVAVEGSIVTVDFSAYNATSGDEIETTTYDEAGQQQFTLDEAQLLPGLLKALQCSVTGDRVVAVIPPADAFQEAGQADLGVAAEDSMVFVIDVVDISEPVEALPRAEGEEQPAEDGFPTVELAEDGAPTITIPDAEAPTELKIANLITGDGEEVAEGANVTVHYTGMVWATGDIFDSSWERGEPATFPTGGVIPGFSKALVGQKVGSQVIAVIPPAEGYGDAPPEGSPIGATDTLVFVVDILATQ

Crispr_ID: NZ_CP017146_12

• CRISPR_ID: NZ_CP017146_12
• CRISPR_location: 1856581-1856662
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP017146_12

Consensus_repeat	Method
CGGGATGGTCGGCGTAGCCGGGATGG	CRISPRCasFinder

spacers of NZ_CP017146_12

>12.1|1856607|30|NZ_CP017146|CRISPRCasFinder
TGGCCGCGAGGTCGGGATGGTCGGCGTAGC

CRISPR arrays and Neighbor proteins around NZ_CP017146_12

CRISPR arrays

The CRISPR arrays of NZ_CP017146_12

>merge|NZ_CP017146|12|1856581-1856662|CRISPRCasFinder
CTGTCTTGTCGACGTGGCTGGGATGGTGGCCGCGAGGTCGGGATGGTCGGCGTAGCCGGGATGGTCGGCGTAGCCGGGATGG

>NZ_CP017146|12|11|1856581-1856662|CRISPRCasFinder
CTGTCTTGTCGACGTGGCTGGGATGG	TGGCCGCGAGGTCGGGATGGTCGGCGTAGC
CGGGATGGTCGGCGTAGCCGGGATGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017146.1|WP_161886100.1|1853324_1854350_+|Fpg/Nei-family-DNA-glycosylase	unknown	unknown	gnl|CDD|176804
NZ_CP017146.1|WP_161886110.1|1871130_1872015_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|223377
NZ_CP017146.1|WP_161886099.1|1852804_1853320_+|ribose-5-phosphate-isomerase	unknown	unknown	gnl|CDD|235509
NZ_CP017146.1|WP_161886103.1|1858479_1860384_-|DUF222-domain-containing-protein	unknown	unknown	gnl|CDD|238038
NZ_CP017146.1|WP_161886108.1|1869091_1869412_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161886101.1|1854410_1855025_+|FMN-binding-negative-transcriptional-regulator	unknown	unknown	gnl|CDD|377290
NZ_CP017146.1|WP_161886104.1|1864917_1865091_-|DUF2510-domain-containing-protein	unknown	unknown	gnl|CDD|378480
NZ_CP017146.1|WP_161885076.1|1857011_1858061_-|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl|CDD|366234
NZ_CP017146.1|WP_161886109.1|1869778_1871146_+|trigger-factor	unknown	unknown	gnl|CDD|234956
NZ_CP017146.1|WP_161886111.1|1872094_1873303_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|99738
NZ_CP017146.1|WP_161887446.1|1849849_1851649_-|amylosucrase	unknown	unknown	gnl|CDD|200463
NZ_CP017146.1|WP_161886096.1|1849091_1849682_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161886106.1|1867484_1868036_-|CGNR-zinc-finger-domain-containing-protein	unknown	unknown	gnl|CDD|378696
NZ_CP017146.1|WP_161886097.1|1851825_1852455_+|disulfide-bond-formation-protein-DsbA	unknown	unknown	gnl|CDD|239320
NZ_CP017146.1|WP_161886105.1|1865303_1867424_-|S9-family-peptidase	unknown	unknown	gnl|CDD|224423
NZ_CP017146.1|WP_161886107.1|1868108_1869065_+|EamA-family-transporter	unknown	unknown	gnl|CDD|273359
NZ_CP017146.1|WP_161887447.1|1855027_1856482_+|amidohydrolase-family-protein	unknown	unknown	gnl|CDD|238625
NZ_CP017146.1|WP_161886094.1|1845460_1846420_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|213235
NZ_CP017146.1|WP_161886095.1|1846475_1849022_-|aminopeptidase-N	unknown	unknown	gnl|CDD|274121
NZ_CP017146.1|WP_161886098.1|1852454_1852784_+|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|368658

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP017146.1|WP_161886100.1|1853324_1854350_+|Fpg/Nei-family-DNA-glycosylase	gnl|CDD|176804	cd08970, AcNei1_N, N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases. This family contains the N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases. It belongs to the FpgNei_N, [N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII)] domain superfamily. DNA glycosylases maintain genome integrity by recognizing base lesions created by ionizing radiation, alkylating or oxidizing agents, and endogenous reactive oxygen species. They initiate the base-excision repair process, which is completed with the help of enzymes such as phosphodiesterases, AP endonucleases, DNA polymerases and DNA ligases. DNA glycosylases cleave the N-glycosyl bond between the sugar and the damaged base, creating an AP (apurinic/apyrimidinic) site. Most FpgNei DNA glycosylases use their N-terminal proline residue as the key catalytic nucleophile, and the reaction proceeds via a Schiff base intermediate. This family contains mostly actinomycetes and includes Mycobacterium tuberculosis Nei1 (MtuNei1). MtuNei1 recognizes oxidized pyrimidines such as thymine glycol (Tg) and 5,6-dihydrouracil on both double stranded and single stranded DNA, it has a strong preference for the 5R isomer of Tg. In addition to this domain, enzymes belonging to this family contain a helix-two turn-helix (H2TH) domain and a zinc-finger motif.	5.51833e-39
NZ_CP017146.1|WP_161886110.1|1871130_1872015_-|SDR-family-oxidoreductase	gnl|CDD|223377	COG0300, DltE, Short-chain dehydrogenases of various substrate specificities [General function prediction only].	2.84431e-81
NZ_CP017146.1|WP_161886099.1|1852804_1853320_+|ribose-5-phosphate-isomerase	gnl|CDD|235509	PRK05571, PRK05571, ribose-5-phosphate isomerase B; Provisional.	4.05955e-71
NZ_CP017146.1|WP_161886106.1|1867484_1868036_-|CGNR-zinc-finger-domain-containing-protein	gnl|CDD|378696	pfam11706, zf-CGNR, CGNR zinc finger. This family consists of a C-terminal zinc finger domain. It seems likely to be DNA-binding given the conservation of many positively charged residues. The domain is named after a highly conserved motif found in many members of the family.	2.85572e-14
NZ_CP017146.1|WP_161886101.1|1854410_1855025_+|FMN-binding-negative-transcriptional-regulator	gnl|CDD|377290	pfam04299, FMN_bind_2, Putative FMN-binding domain. In Bacillus subtilis, family member PAI 2/ORF-2 was found to be essential for growth. The SUPERFAMILY database finds that this domain is related to FMN-binding domains, suggesting this protein is also FMN-binding.	5.30427e-50
NZ_CP017146.1|WP_161886104.1|1864917_1865091_-|DUF2510-domain-containing-protein	gnl|CDD|378480	pfam10708, DUF2510, Protein of unknown function (DUF2510). This is family of proteins conserved in Actinobacteria. Many members are annotated as putative membrane proteins but this could not be confirmed.	0.000877273
NZ_CP017146.1|WP_161885076.1|1857011_1858061_-|DDE-type-integrase/transposase/recombinase	gnl|CDD|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	6.52128e-24
NZ_CP017146.1|WP_161886111.1|1872094_1873303_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl|CDD|99738	cd00614, CGS_like, CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.	5.00599e-138
NZ_CP017146.1|WP_161887446.1|1849849_1851649_-|amylosucrase	gnl|CDD|200463	cd11324, AmyAc_Amylosucrase, Alpha amylase catalytic domain found in Amylosucrase. Amylosucrase is a glucosyltransferase that catalyzes the transfer of a D-glucopyranosyl moiety from sucrose onto an acceptor molecule. When the acceptor is another saccharide, only alpha-1,4 linkages are produced. Unlike most amylopolysaccharide synthases, it does not require any alpha-D-glucosyl nucleoside diphosphate substrate. In the presence of glycogen it catalyzes the transfer of a D-glucose moiety onto a glycogen branch, but in its absence, it hydrolyzes sucrose and synthesizes polymers, smaller maltosaccharides, and sucrose isoforms. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NZ_CP017146.1|WP_161886103.1|1858479_1860384_-|DUF222-domain-containing-protein	gnl|CDD|238038	cd00085, HNHc, HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.	3.90428e-13
NZ_CP017146.1|WP_161886109.1|1869778_1871146_+|trigger-factor	gnl|CDD|234956	PRK01490, tig, trigger factor; Provisional.	1.12341e-134
NZ_CP017146.1|WP_161886097.1|1851825_1852455_+|disulfide-bond-formation-protein-DsbA	gnl|CDD|239320	cd03022, DsbA_HCCA_Iso, DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1,2-dihydroxynapthalene by a dioxygenase, into cis-o-hydroxybenzylidenepyruvate (cHBPA). This is the fourth reaction in a six-step pathway that converts napthalene into salicylate. HCCA isomerase is unique to bacteria that degrade polycyclic aromatic compounds. It is closely related to the eukaryotic protein, GSH transferase kappa (GSTK).	9.69856e-06
NZ_CP017146.1|WP_161886105.1|1865303_1867424_-|S9-family-peptidase	gnl|CDD|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	2.11754e-68
NZ_CP017146.1|WP_161886107.1|1868108_1869065_+|EamA-family-transporter	gnl|CDD|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.74331e-15
NZ_CP017146.1|WP_161887447.1|1855027_1856482_+|amidohydrolase-family-protein	gnl|CDD|238625	cd01300, YtcJ_like, YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling.	1.32349e-103
NZ_CP017146.1|WP_161886094.1|1845460_1846420_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	1.16983e-85
NZ_CP017146.1|WP_161886095.1|1846475_1849022_-|aminopeptidase-N	gnl|CDD|274121	TIGR02412, Aminopeptidase_N, aminopeptidase N, Streptomyces lividans type. This family is a subset of the members of the zinc metallopeptidase family M1 (pfam01433), with a single member characterized in Streptomyces lividans 66 and designated aminopeptidase N. The spectrum of activity may differ somewhat from the aminopeptidase N clade of E. coli and most other Proteobacteria, well separated phylogenetically within the M1 family. The M1 family also includes leukotriene A-4 hydrolase/aminopeptidase (with a bifunctional active site).	0
NZ_CP017146.1|WP_161886098.1|1852454_1852784_+|cupin-domain-containing-protein	gnl|CDD|368658	pfam05899, Cupin_3, Protein of unknown function (DUF861). This family consists of several proteins which seem to be specific to plants and bacteria. The function of this family is unknown.	4.43923e-10

Protein sequences

>NZ_CP017146.1|WP_161887447.1|1855027_1856482_+|amidohydrolase-family-protein
MLLKGARIVGGIGASAPVDILLKHGVITGIGTGLTGTATIDLDGRYVMPGLWDGHVHLTQTALTRRRVDLTAATSATDAAAIMAAADRPAEGLPLIGFGFRDGMWAAPPTKHDLDAVVGDIPVVVLSGDLHCAWLNSAALAAFGMGGHPTGLLREEDAFKVTTEAQTVPADVLDDWVAATATDVARRGVVGVVDLEMADTVQDWTRRFAAGFRGLRIAVGVYTPWLDSAIEAGLRTGQVIEGTDGLLSVGPFKIITDGSLNTRTAFCGEPYEGLVGPDASGQLNLPTVELVALMRKASRAGLIPAVHAIGDEANRLALDSFAAAGCSGRIEHAQLVRDVDCARFAALGVAASVQPEHAMDDRDIADRLWSGRTDRAFALRSLLDAGAELILGSDAPVAPLDPWVTIAAAVGRTRDGREPWHPEQRITIAQALAASTNGVRSVAVGNVADLAILDIDPLTAPLDQLRAMPVAATLLAGYFTHNEL
>NZ_CP017146.1|WP_161886101.1|1854410_1855025_+|FMN-binding-negative-transcriptional-regulator
MRNTPQYVLDDPDEVRRLIRENPWATIVSNTSTGLVASHYPVILEEGTDQISIVSHVGRPDEQLHELGRHEVLVIIQGPHGYISPSWYASDDFVPTWNHVTAHLYGTPEVLSDEENFRVLGELVDHFEAPLPEPMSLDIDEAQARRIARGTVGLRLVVTRFDARLKLSQNKPGAVVDRIVEQLEHGNHYAQPALAREMRLVQGE
>NZ_CP017146.1|WP_161886100.1|1853324_1854350_+|Fpg/Nei-family-DNA-glycosylase
MPEGHSVHRIARQFRLHFVGKRVSASSPQGRFAAGAAELDGHVMTDARAVGKQMFLEFDHERWLRVHLGMYGAWDFAGDITADATVLAANGRMGQTNQKGTPEQSGTPGELGTPGQPVTVDAAGEDSLHSIGAPRVARLRMAEQEKLGPGADTFPPEPIGAVRVRLLTHDTVADLRGPTACEVLGAEEVQAVIARLGPDPLVDPGKRSEDRFVEVVRKKPTPIGLLLMDQSVVSGIGNVYRAELLFRAHLNPHTPGRDVPEETVRALWRDWSKLLKLGVQHGQMMTMDRLGAKQKAAALAHREDRHWVYHRAGLPCRVCGTPIAVEMAAGRKLYWCPKDQA
>NZ_CP017146.1|WP_161886099.1|1852804_1853320_+|ribose-5-phosphate-isomerase
MRIHIATDHAGLDFSRDLRAHLRGAGHEVVDHGPQSYDPLDDYPSFCINAAIAVVAEQAAGIPSLGVVFGGSGNGEQIAANKVTGARAALVWSDATARLAREHNDANVISIGARQHTVEEAKAFIDAFIEQPYTNEERHARRIAQLAEYERSGRIAGHRIDSPAAPEPGRV
>NZ_CP017146.1|WP_161886098.1|1852454_1852784_+|cupin-domain-containing-protein
MIDHAEALAAVLSHEPVPAEQVVAGQPTTGSVALGTFAGREYGVWEMSPGAMSDVEVDELFVVVAGGGRIEFADGSARVELLPGSVGRFDAGTATVWTVTETLRKIYLA
>NZ_CP017146.1|WP_161886097.1|1851825_1852455_+|disulfide-bond-formation-protein-DsbA
MTSVPAAASDTVRVEFWFDPSCPWAWMTSRWVDEVARHRDIAVTWNIMSLAVLNEDNDVDDAHSAFLPRALKYTRLVAAAKEIHGQEAVKDLYDALGTRIHLEGDADPDSVIPAALNEAGLPADLARFADTDEYDVQMRASHFEGIGRVGQDVGTPVIAVNGVAFFGPVISPAPKGERALVLWDGVVAAASYDGFFELKRSRTRGPIFD
>NZ_CP017146.1|WP_161887446.1|1849849_1851649_-|amylosucrase
MYPTLRELFTEVYGERDDCDEQLALLVQQMADSWQDRAPELKEFDARREANPDWFQSADMLGGVCYVDRYAGDLDGVRAKIPYFQELGLTYLHLMPLFLAPERNSDGGYAVSSYRDVNPALGDMDQLRVLAADLRAAGISLVVDFIFNHTSNEHEWARRAIARDDGFEDYYWMFPDREMPDAYEQTVREIFPDDHPGSFVQLEDGRWVWATFHSFQWDLNYSNPAVFRAMAGEMLFLANVGIDILRMDAVAFIWKQLGTVCESLPQAHTLIKAFNAVCRIAAPSLLFKSEAIVHPDEVVRYIDPAECQLSYNPLQMALIWESLATRSVGLLSQALDRRHNLPAGTAWINYVRSHDDIGWTFSDEDAAELGLDGTEHRRFLNAFFVNRFEGSFARGVPFQDNPRTGDCRIAGTTASLVGLGQHHPGAISRIHLAHSIVLSTGGIPLIYLGDEVGQLNDYSYTDNPDHALDSRWVNRPPYPADRYAERDDPRTDAGMIYAGLHRLIEVRRDAPELAGGQLIGFETNNPHVLGYQRPGAGTTVLVLANFADTDELVSAATLSGFVPSAHELTRGEDVSLAGGLRLRPHEFAWLRTAEVNPPN
>NZ_CP017146.1|WP_161886096.1|1849091_1849682_-|hypothetical-protein
MEFASFLAGERWTDHPTCTHPALASLSRLVNDWTTDASRSRLGEMIPSVIGLVGDDERVELTIAVRAASAALPVASEARQRALAVGLIRCEARLAEVDPEGAAGVNLIVRAALNRAPLAELWATQQLASLMRRQPKAFAPMYDAIVNVAVAGIGEACIDNPDERLRKLLQTAIDDCDRLLRTPDQSRQRTVSLTPA
>NZ_CP017146.1|WP_161886095.1|1846475_1849022_-|aminopeptidase-N
MPGENLTRVEAQERKATVSVENYDITLDLTTDSETFRSTTVVRFSASAGASTFIDHLTRTVHSVHLNGRELDPAAVNDGVRIQLHDLADLNVLTVVADAEYTNTGEGLHRFVDPVDDEVYLYSQFEVPDSRRVFAVFEQPDLKATFTFTITAPAAWAVVSNSPTPTPEPIEGTTSATWRFAPTPVLSSYVTAIVAGPYQETRSTLTSSDGRVIPLGIFARKSLSQYLDADYIFAKTREGFAYFEEKFDYAYPFEKYDQLFVPEFNAGAMENAGAVTFTETYVFRGKVTDAVRERRVVTILHELAHMWFGDLVTMKWWNDLWLNESFAEWASTIATAEATEWTEAWTTFQAMEKSWAYKQDQLPSTHPVFATINDLEDVQVNFDGITYAKGGSVLKQLVAWVGIDAFYAGVAAYFKKHAYGNTELGDLFTELEATSGRELTEWSKLWLETAGVNTLRPEIETDAAGKITSFAILQTAAPDYPTIRPHRLAIGFYDLAGGKLVRDDRLETDVDGERTEVPGFVGRQRPALILVNDDDLAYAKVRLDEQSLGTAIDHLSAIDNPLARAIVWGSVWDSTRDGESTASDYVRLVLGNIATESESTTIRTTLTQLLTVVRIYVDPATRTETLKNVADKLLELARAADAGSDAQFQFVKFFANLANTPEHVAALRGLLDGSTPLDGLEVDTDLGWELLEGLVLNGAAGLEEIRQALAKDNTANGQQAAARVTAAIPTTEGKLAAFSSLVDSDELPNAIVRQTTVGFQHTNDPSSLQPVVARYFDSIRGIWESRSHSIAENLIVGLYPAGLANAALRDATTSWLTANPDTPALRRLVIENLAGVERALMVQAKDTE
>NZ_CP017146.1|WP_161886094.1|1845460_1846420_-|ATP-binding-cassette-domain-containing-protein
MIEARELSKHYGSKKAVDGISFTVRPGMVTGFLGPNGAGKSTTMRLIVGLDRATSGSVTVNGKPYAAHRAPLREVGMLLDAKAIHTGRSAVNHLLAVGATHGIGRTRVDEVIGLTGLDSVARKRVGGFSLGMGQRLGIAAALLGDPATLVLDEPVNGLDPEGVMWVRSLARQLASEGRTIFLSSHLMSEMALTADHIIVLGRGRVIADAPVADIVALSGGTLVRVRTPHAARLRELLASTELGTQVQVHPGSSTNEPDVFQVSGLDAARIGELAASAGLALHELTPVAGSLEEAYMSLTQNEVEYHAGGTASASEGASQ
>NZ_CP017146.1|WP_161885076.1|1857011_1858061_-|DDE-type-integrase/transposase/recombinase
MTAGTVLDDAFTALIGLAVTVVAACALTGRSRATHYRRISPPVRKIDPIPQAARAKPPSTLSETERGQVLAVINSPAYQDLSICQIWARELDEDRYHCSMSSMYRIARAAGQTRERRRLATHPAKVKPELVALGPSQVWSWDITKLRGPRKGVWYHLYALIDIYSRYSPSHVVCAAEDSVVARDFIDDAIGRNGTAPHTVHADRGTSMTSKPVSALLADLGITRTHSRPRVSNDNPYSEAQFKTLKYVPDFPHHFYSLAEAKQFCDGFFTDYNHIHHHSGIGWHTPASVHFGTYQDIDQQRSVTLNRAFNEHPERFTRRPRPPQIRTEVWINEPQKEALPINDQTTQTV
>NZ_CP017146.1|WP_161886103.1|1858479_1860384_-|DUF222-domain-containing-protein
MEQLPNTLRDTADTVAGLGACAGEFTALDDASLFAAQRSVTALRRAVDTYAAWIAAAIAKHSDRALGHAGMAISAGFVSAEALIQSISGSTRAEAAKLVQIGTLLAETEAAEALAAADPTATATGGTPTAGAPTAGAPTAGAPTAGAPVSDPGSPASPGPATDPAEPRFPVGMPVWQAPIARAVTAGLLSLDGAEAIRRGLGGIDDAVTAEQLTAAAEHLITAINPSNPSNPSNPGNPGSAGAGRVLGADEVQRLARRLRDELDSDGIRRREKEQYDLRAVRKWRTADGMHHGIWHLHPEDGALLDSALSTILSPRRGGPRFIDPEEKAKAQKLVEDPRTDEQILADALIGMIRIATDADPGTMFGSRRPAVRVIITKKDLTTNTTPTAGTSTDASTGTGTGTGTPSGPTLPVLPVLPVLPPPSQSAQPLAPPHPAQPPLPPPPPPRLRLPGISADQGWIEGTLDPISIETIQRNLCDTGHIPVLFDDDGQCLNVGHTRRHFTARQRIALATRDGGCMFPSCDRPPSWCEAHHIKHWDRDNGPTNIDNGILLCRRHHLLLHDNHWEITNTNNNYWLQPPRNIDPTQTLILLPSRTPTITAITAIARRNASPSLSGWCETSRVMRGVLGEGGERT
>NZ_CP017146.1|WP_161886104.1|1864917_1865091_-|DUF2510-domain-containing-protein
MPASENSPLAPSGWYRDPLGLPQLRWWNGMMWTNQIEEPRAEIQVSSAYKVELVSSP
>NZ_CP017146.1|WP_161886105.1|1865303_1867424_-|S9-family-peptidase
MSAQVHQVHLPFSSLDDFIALPRIEGLALSPDGHRVVLTVATLARDSTSYERALWAVPADGTGAPTRLTRSAKGESGVAFTGSGDVMFVSGRPDAAAEKDTEAAQLWLLPASGGEARAVTRLAGGVSGIAATATSSDTIVITADLLPSADGLEADAAARKNRSDKKVSAILHESYPVRYWDHDLGPAEPHLLSLDLSNLAESISAPVTADPNPDPAAAAAAAAAYPAELPRPNDLTPAPGRAGDTAGQALTPDGRTMIASLRVREQRSGRHVLVAIDVESGQRTTLFDEDRVHFQSPVVSRDGSRVAFVRSAFSTPEGPADQEIWVAGIDGSEPRRLGADWDRWPSSTIFDLGDESLIVTADHGGRGPIFRIPLDGSAAAQLTSDDFSYTHVAVDPTTGDLVALRSSWMAPSHPVRITRAGDVVPLATPATPATLPEAPGSITEVETVAEDGSPLRAWLLLPDGSDAQHPAPLLLWIHGGPLNSWNAWSWRWSPLLAVARGYAVLLPDPALSTGYGLDFIARGWDAWGTKPYTDLLAITDATEARPDIDAAKTAAMGGSFGGYMANWIAGHTDRFTAIVSHASLWALDQFNGTTDNSQYWQSIFSPQGMLDSSPHHSVRDISTPMLVIHGDRDYRVPVGESLRLWSELAEHHAEPDGTTRHKFLYFPNENHWVLGPQHAVVWYETVFAFLDQHVHGADWKRPEALG
>NZ_CP017146.1|WP_161886106.1|1867484_1868036_-|CGNR-zinc-finger-domain-containing-protein
MHFAPDTEDLLAFNVALANTVPSSTRSGTDELSSTLQLQALLAIHGYTGRVDRDDAELGDVRAARLELRRIWALDRDSMASEVNAMLRDTRALPQLARHDGFDWHLHATRADAPLAERIRAEGALALVDVIRSDGTDRLRICEADDCEGLFADLSRNGSRRYCTVRCGNRMNMVAHRRRQSAE
>NZ_CP017146.1|WP_161886107.1|1868108_1869065_+|EamA-family-transporter
MNRSPLSAGLMFALVAAASFGVSGALIKPLLEGGWSPAAAVTVRALTGGLILAPFAVIALRGRWGSVWLGRWRILGMATVGVAGTQLFYFAAVQRIPVGTAILIEYMAPLLLVAVAWAMTRRRPAVVVLAGSVAAFAGLLLIVSPSGSGALDPLGIASAVTAMVCCAGYFVIAARPSAGLPPVALASAGLLIAPVLLALAGLLGMVPFTASVDEVTLLGRATPWWVPMLVVGVVSTAVAYATSITAGGMLGSRLASFVGLLEVAAAGLWAWMLLGESLTMLQLFGGGLILVGIGFVHSDRSVPVAPVGEKTPAFGPSR
>NZ_CP017146.1|WP_161886108.1|1869091_1869412_+|hypothetical-protein
MNETTESSRKRPETHGSSEAGRYLRFIDWLNRSLEGPLGPPPSGPFDEVVQQVGAATCPVCNRPMSEHRIDHTVSNAVLHCPVGHERPAEHQEPLNELGMPKRPHD
>NZ_CP017146.1|WP_161886109.1|1869778_1871146_+|trigger-factor
MKTTVEKLSPTRVKLTIAVTPDELKPSVDHAYTHLAESINIPGFRKGKVPPPIIDQRVGRGEVLNHAVSDGLDKFYRLAVTEEKIRPLGRPEADVTGLPELKDFSGDLVIVVEVDVRPEFTLPSIDGLELTVDTATVEPDEVETELQNLLARFGTLVTVERPAKTGDFAQIDLVASIDGTEVDTANAISYEVGSGDLIDGIDEALDALSAGETTTFESKLLGGDNEGQTAQITVNLLAVKERELPAADDDFAQIASQFDTIDELKADIEQQVIKSKVFGQGAQARDQVVDKLLESVEIPVPEKLVEDEVHRHLENENRLEDAEHRAEVAESSEKTFRTQILLDSIAEQEKVKVSQNELTQYLVQGAAQYNMEPGEFIKVLDQNGQIPGMIGEVARAKALAIVLSRANVVDGNGDVVDISSFTATALSDAGDDSDASDFVEAASTADDDHEGHDHS
>NZ_CP017146.1|WP_161886110.1|1871130_1872015_-|SDR-family-oxidoreductase
MALDYRGTTALITGASSGLGTEFARQLAARGANLVLVARRLDRLDSLANELTASHGITATTITADLAAPGAAANLHADLGERGIRISTLINNAGFGTRSRFENEAAGRIHEEVSLNVTALVELTHAFYAQLQEGRGALVTLASTAAYQPVPLMAVYAASKAFVLSFTEALWYENKDTALLVLALSPGATRTEFFDVAGAGARVGDFEEPADVVGLALSTLDSKNPPPSVVSGARNRAMSIASTLAPRRTVVNLTGSMTGRNPACGLNDEGVLTTKARHCCAGPSSSVHAVQLWS
>NZ_CP017146.1|WP_161886111.1|1872094_1873303_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MTSRPDKHDPLTLRLLTQAVHAGNAIDPGTGAVRTPLVLANSYALPDDPSEISWSGTDIPLYTRNSGVNQLALQQKLAVLDNGEDAVALASGVAALHAVFFTFLKSGDHVVVADVVYEATHRLFTELLPEKYGIEATLVDTTDLAAVRAAIRPTTRLVHVETPANPTTRITDIHELALIAHKAGALLSVDSTFASPLLLRPLDQGADLVVHSLTKYINGHGDAMGGAVIGSRELIQQIKSDAMIDVGGVISPFNAWLIMRGSITLPLRIRQHCVNARAVADVLDADDRVAFVAYPGLASHPQHELARRTMPNGFGGMLAFAVVGDSATQDRFVSNLRVITSAVSLGHDESLIVHVGSTAPRAAHWPEEFRTNGHLRFSVGIEDPADLIADLRAALDATFAPD

Crispr_ID: NZ_CP017146_13

• CRISPR_ID: NZ_CP017146_13
• CRISPR_location: 3050515-3050623
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP017146_13

Consensus_repeat	Method
AAGCAACACAAGTGGGCGACTCGCGCG	CRISPRCasFinder

spacers of NZ_CP017146_13

>13.1|3050542|55|NZ_CP017146|CRISPRCasFinder
AGATTGCGCCCTCACACCCGCGAACGGCCCACATAAGTCCCTTCTGGGGCCCGCC

CRISPR arrays and Neighbor proteins around NZ_CP017146_13

CRISPR arrays

The CRISPR arrays of NZ_CP017146_13

>merge|NZ_CP017146|13|3050515-3050623|CRISPRCasFinder
AAGCAACACAAGTGGGCGACTCGCGCGAGATTGCGCCCTCACACCCGCGAACGGCCCACATAAGTCCCTTCTGGGGCCCGCCAAGCAACACAAGTGGGCAACTCGCGCG

>NZ_CP017146|13|12|3050515-3050623|CRISPRCasFinder
AAGCAACACAAGTGGGCGACTCGCGCG	AGATTGCGCCCTCACACCCGCGAACGGCCCACATAAGTCCCTTCTGGGGCCCGCC
AAGCAACACAAGTGGGCAACTCGCGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017146.1|WP_161887025.1|3053700_3054000_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	unknown	unknown	gnl|CDD|178810
NZ_CP017146.1|WP_161887022.1|3049861_3050458_+|energy-coupling-factor-transporter-transmembrane-protein-EcfT	unknown	unknown	gnl|CDD|223692
NZ_CP017146.1|WP_161887028.1|3056205_3058482_-|NAD-dependent-DNA-ligase-LigA	unknown	unknown	gnl|CDD|223350
NZ_CP017146.1|WP_161887018.1|3043440_3043800_-|DUF202-domain-containing-protein	unknown	unknown	gnl|CDD|225060
NZ_CP017146.1|WP_161887030.1|3059753_3060311_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP017146.1|WP_161887021.1|3048561_3049176_+|biotin-transporter-BioY	unknown	unknown	gnl|CDD|224187
NZ_CP017146.1|WP_161887029.1|3058557_3059706_-|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl|CDD|234664
NZ_CP017146.1|WP_161887027.1|3054650_3056063_-|hypothetical-protein	unknown	unknown	gnl|CDD|283837
NZ_CP017146.1|WP_161887026.1|3054177_3054630_+|META-domain-containing-protein	unknown	unknown	gnl|CDD|377111
NZ_CP017146.1|WP_161887016.1|3042550_3043075_+|DUF1697-domain-containing-protein	unknown	unknown	gnl|CDD|377954
NZ_CP017146.1|WP_161887017.1|3043093_3043435_-|DUF202-domain-containing-protein	unknown	unknown	gnl|CDD|376882
NZ_CP017146.1|WP_161887015.1|3041408_3042551_+|NYN-domain-containing-protein	unknown	unknown	gnl|CDD|350237
NZ_CP017146.1|WP_161887019.1|3044000_3045344_+|MFS-transporter	unknown	unknown	gnl|CDD|236700
NZ_CP017146.1|WP_161887031.1|3060303_3061464_-|cysteine-desulfurase	unknown	unknown	gnl|CDD|224029
NZ_CP017146.1|WP_161887568.1|3049229_3049865_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213192
NZ_CP017146.1|WP_161887024.1|3052162_3053701_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	unknown	unknown	gnl|CDD|234572
NZ_CP017146.1|WP_161887032.1|3061525_3063565_+|glycogen-debranching-protein-GlgX	unknown	unknown	gnl|CDD|200465
NZ_CP017146.1|WP_161887567.1|3045676_3047629_+|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl|CDD|334157
NZ_CP017146.1|WP_161887020.1|3047830_3048487_-|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|172294
NZ_CP017146.1|WP_161887023.1|3050657_3052163_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	unknown	unknown	gnl|CDD|235489

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP017146.1|WP_161887025.1|3053700_3054000_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	gnl|CDD|178810	PRK00034, gatC, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC.	7.65036e-32
NZ_CP017146.1|WP_161887022.1|3049861_3050458_+|energy-coupling-factor-transporter-transmembrane-protein-EcfT	gnl|CDD|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	1.05317e-15
NZ_CP017146.1|WP_161887028.1|3056205_3058482_-|NAD-dependent-DNA-ligase-LigA	gnl|CDD|223350	COG0272, Lig, NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair].	0
NZ_CP017146.1|WP_161887018.1|3043440_3043800_-|DUF202-domain-containing-protein	gnl|CDD|225060	COG2149, COG2149, Predicted membrane protein [Function unknown].	6.82169e-19
NZ_CP017146.1|WP_161887021.1|3048561_3049176_+|biotin-transporter-BioY	gnl|CDD|224187	COG1268, BioY, Uncharacterized conserved protein [General function prediction only].	8.29032e-35
NZ_CP017146.1|WP_161887029.1|3058557_3059706_-|tRNA-2-thiouridine(34)-synthase-MnmA	gnl|CDD|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NZ_CP017146.1|WP_161887027.1|3054650_3056063_-|hypothetical-protein	gnl|CDD|283837	pfam06259, Abhydrolase_8, Alpha/beta hydrolase. Members of this family are predicted to have an alpha/beta hydrolase fold. They contain a predicted Ser-His-Asp catalytic triad, in which the serine is likely to act as a nucleophile.	2.96104e-23
NZ_CP017146.1|WP_161887026.1|3054177_3054630_+|META-domain-containing-protein	gnl|CDD|377111	pfam03724, META, META domain. Small domain family found in proteins of of unknown function. Some are secreted and implicated in motility in bacteria. Also occurs in Leishmania spp. as an essential gene. Over-expression in L.amazonensis increases virulence. A pair of cysteine residues show correlated conservation, suggesting that they form a disulphide bond.	1.90336e-10
NZ_CP017146.1|WP_161887016.1|3042550_3043075_+|DUF1697-domain-containing-protein	gnl|CDD|377954	pfam08002, DUF1697, Protein of unknown function (DUF1697). This family contains many hypothetical bacterial proteins.	1.11713e-39
NZ_CP017146.1|WP_161887017.1|3043093_3043435_-|DUF202-domain-containing-protein	gnl|CDD|376882	pfam02656, DUF202, Domain of unknown function (DUF202). This family consists of hypothetical proteins some of which are putative membrane proteins. No functional information or experimental verification of function is known. This domain is around 100 amino acids long.	0.000310916
NZ_CP017146.1|WP_161887015.1|3041408_3042551_+|NYN-domain-containing-protein	gnl|CDD|350237	cd11297, PIN_LabA-like_N_1, uncharacterized subfamily of N-terminal LabA-like PIN domains. This N-terminal LabA-like PIN domain is found in a well conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. LabA from Synechococcus elongatus PCC 7942, (which does not contain this C-terminal domain), has been shown to play a role in cyanobacterial circadian timing. The LabA-like C-terminal domains characteristic of this subfamily may be related to the LOTUS domain family (which also co-occurs with LabA-like N-terminal domains). The function of the N-terminal domain is unknown. The LabA-like PIN domain family also includes the N-terminal domain of limkain b1, a human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes. Other members are the LabA-like PIN domains of human ZNF451, uncharacterized Bacillus subtilis YqxD and Escherichia coli YaiI. Curiously, a gene labeled NicB from Pseudomonas putida S16, which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like PIN family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.16346e-35
NZ_CP017146.1|WP_161887019.1|3044000_3045344_+|MFS-transporter	gnl|CDD|236700	PRK10489, PRK10489, enterobactin transporter EntS.	1.85782e-57
NZ_CP017146.1|WP_161887031.1|3060303_3061464_-|cysteine-desulfurase	gnl|CDD|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	1.68252e-141
NZ_CP017146.1|WP_161887568.1|3049229_3049865_+|ABC-transporter-ATP-binding-protein	gnl|CDD|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	1.74195e-73
NZ_CP017146.1|WP_161887024.1|3052162_3053701_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	gnl|CDD|234572	PRK00012, gatA, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA.	0
NZ_CP017146.1|WP_161887032.1|3061525_3063565_+|glycogen-debranching-protein-GlgX	gnl|CDD|200465	cd11326, AmyAc_Glg_debranch, Alpha amylase catalytic domain found in glycogen debranching enzymes. Debranching enzymes facilitate the breakdown of glycogen through glucosyltransferase and glucosidase activity. These activities are performed by a single enzyme in mammals, yeast, and some bacteria, but by two distinct enzymes in Escherichia coli and other bacteria. Debranching enzymes perform two activities: 4-alpha-D-glucanotransferase (EC 2.4.1.25) and amylo-1,6-glucosidase (EC 3.2.1.33). 4-alpha-D-glucanotransferase catalyzes the endohydrolysis of 1,6-alpha-D-glucoside linkages at points of branching in chains of 1,4-linked alpha-D-glucose residues. Amylo-alpha-1,6-glucosidase catalyzes the endohydrolysis of 1,6-alpha-D-glucoside linkages at points of branching in chains of 1,4-linked alpha-D-glucose residues. In Escherichia coli, GlgX is the debranching enzyme and malQ is the 4-alpha-glucanotransferase. TreX, an archaeal glycogen-debranching enzyme has dual activities like mammals and yeast, but is structurally similar to GlgX. TreX exists in two oligomeric states, a dimer and tetramer. Isoamylase (EC 3.2.1.68) is one of the starch-debranching enzymes that catalyzes the hydrolysis of alpha-1,6-glucosidic linkages specific in alpha-glucans such as amylopectin or glycogen and their beta-limit dextrins. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NZ_CP017146.1|WP_161887567.1|3045676_3047629_+|UvrD-helicase-domain-containing-protein	gnl|CDD|334157	pfam00580, UvrD-helicase, UvrD/REP helicase N-terminal domain. The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Some members have large insertions near to the carboxy-terminus relative to other members of the family.	6.00333e-21
NZ_CP017146.1|WP_161887020.1|3047830_3048487_-|TetR-family-transcriptional-regulator	gnl|CDD|172294	PRK13756, PRK13756, TetR family transcriptional regulator.	4.90911e-20
NZ_CP017146.1|WP_161887023.1|3050657_3052163_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	gnl|CDD|235489	PRK05477, gatB, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB.	0

Protein sequences

>NZ_CP017146.1|WP_161887022.1|3049861_3050458_+|energy-coupling-factor-transporter-transmembrane-protein-EcfT
MIALYLPGTSPIHRMPAGPKVLIFMALTLAITLAARSAWALPALFALVVGGYLVAGLGMRDLLRQVVVVRWVMLVMLLAQLVFLPPLVAVANTGRVLTVIVLAALITLTTRIPDLLDATERSLAPLRRFGVNPSSIGLLLAMTITAIPVIAGFAASIREAQRARGVPLRIGTFVVPLLVMALKHSDDLADALVARGVE
>NZ_CP017146.1|WP_161887568.1|3049229_3049865_+|ABC-transporter-ATP-binding-protein
MALRDVSVMLPERRIAVIGSNGSGKSTFARMLNGLVAPSAGHVRVHGLDPAREAKQLRRRVGFIFSNPDAQIVMPTVAEDVAFSLRGQGLARDEVAERVAATLGTYGLDALADAPAHTLSGGQKQLLALAAILIRQPALIVADEPTALLDAANTRRIGNHLLDELAQQLVLVTHDMRLAARCDVVLRFEDGRMLERGDPRDVIAHYEREHA
>NZ_CP017146.1|WP_161887021.1|3048561_3049176_+|biotin-transporter-BioY
MARRVRIDIRDITRIAIFAAIIAVLGIPGAIPAFGGAVPITAQTLGVMLAGAVLGSWRGAAAVLTFLALVFVGLPLLSGGRGGVGVFAGATVGYLIGWVFGAFVVGAIAQAGTRRPTWWWTALGCFVGGILVVYTFGIPLQSLITQLPLAETVLASAVFLPGDILKVVIATVITMALWRAYPRAFRREARGGEAVPATAPPVLR
>NZ_CP017146.1|WP_161887020.1|3047830_3048487_-|TetR-family-transcriptional-regulator
MTNDDGSAARYPRHSRDDVVAAAMAVLDQNGLPDLTMRRLAATLDVQPSALYWHFANKQTLLASVADQIVARARPSFAAHGGDWAEATRAEADALRDALLAYRDGAEVVSSTLALGLGAGEAIARLTGAIDGGGFDRRTSECAAAAVLHFVLGHVSHEQQRLQADSLGVVVAEQSADAAQVSTSAGGREAFDFGITLLLAGLAVLAPAPSAPRRESPA
>NZ_CP017146.1|WP_161887567.1|3045676_3047629_+|UvrD-helicase-domain-containing-protein
MAERWMIAHHTERQVAGSLAPLTAAGYTFLHDRGWPGSRRAQVDHVLVGPGGLFIVDTKAWAEVQIAGGRIFRGQADVTDDLAGLADLAWGTEAVMAEHGLAPGEVHVVVVLANRNVPPTEVGSLIVVGERQAAKYINSRGVRLTPVQTNTVLGVAMQHFPVLGEAPTKLDLSIPQPALAEAAPEPLVTVEDVTEVLLAGLMAAPIEEWMAFLHPDQAKLVRRNFGGPSRIRGAAGTGKTVVGLHRAAYLARSQPDKILVTTFVSTLPAVLSSLLHRLAPEAVDRVEFAGVHSFARRLLGQRGVRLNLAPKEADALFTALWQEHGLPGTLGKADSNKQYWRDELSKVIKGRGLTTFEQYADLARTGRRRPLGVDQRRAVWQLFTGYEAGLKQRGIHDFDDVILQAEASLRETPLEGWGGVIIDEAQDLSCAMVRMLHLLVGDSPDGLTLIGDGQQSIYPGGFTLAEAGVSIAGRGVIMSTNYRNTREIAAFAASLVADDEFTDIEGLVGAGDRITNVARSGESPVSDRFASRKAHDAALVERVRGAGPLGDIGVLCLTTWGVAGAVTALTAAGIPIIELTGYDGTPTNAVKVGTVKRAKGLEFKQVLVGRVPAALLDSPARGDEAKEIQRRELYVAMTRARDGLWVGVCA
>NZ_CP017146.1|WP_161887019.1|3044000_3045344_+|MFS-transporter
MTDQLPLDPERATAPQGVRGHFVDLAPLRESPAFARMWIGGLITGIGSQLTIVAVGLHIYELTASTLAVSLVAAFALVPMILAGLYGGALADSFDRRKVALLAAVVAWGSVLALASVSWLDVTQLWPLYALITVNTVASTMVHVARQAIVPRLIRRELLPAAGALGGMAGGIMLTVGPALAGVLVAYAGVSWTYTIDAVLFLAAFYGLYTLPGTLPEGEKRKPNLRTIVDGIRFLKHAPNIRASFLIDIFAMTFGNPRVLLPAVGALLIGGGAVTVGILTSAVAVGVLLISVFSGRLGGIRRQGIAMAIAVVAYGASILLFGGVLLVTALVPHDVGPDIADASLPALLAASVLLALSGAADNVSMIFRNTMLQAAVPDEMRGRLQGIFTVVVTGGPRVGDLYVGVLSLTALLWFPPLLGGLVIVVAAAVILRVTRSLREYDALDPQP
>NZ_CP017146.1|WP_161887018.1|3043440_3043800_-|DUF202-domain-containing-protein
MRSRFPRGVFELGDEPDPRFSLANERTFLAWIRTSLALLLAGVALEALDAPIQAELRLASALIFIALGLVSIVHAWWSWAATERSMRLAQPLPGLAIGAVITSGAAIAIVGIIVGSLLV
>NZ_CP017146.1|WP_161887017.1|3043093_3043435_-|DUF202-domain-containing-protein
MRIFESGLQPERTLLAWRRTCLVLGLGVAVSIRFGAIADPLMALLIGVPGLALVGGAYALTSIRYHRATRALVNDPTAAVSEGRAIAAVTVVALLVGLAALVFVVAQSEVLSR
>NZ_CP017146.1|WP_161887016.1|3042550_3043075_+|DUF1697-domain-containing-protein
MTVYVALVRAVNVGGTGTLPMTRLAELCTSLGLRHVRTYIQSGNVVFSSPWSADAARTALEMALTDELGTPAQVIIRTAAELERSVSSNPFPDAEGAKVGVALAHEPVPAAVVGGIPTPGGEQVVAGERELYVYYPDGMGRSKLTLPKSLGPVTVRNMNTMTKLVSLTRDIPAG
>NZ_CP017146.1|WP_161887015.1|3041408_3042551_+|NYN-domain-containing-protein
MAEASDPRVAVYIDFDNIVISRYDQVYGRGRFMADKARNGTDGEPTEAKAKEQALRAIVDVGAIIDYATSFGTVVISRAFADWSVPANSRYRRQLVDRAIDLTQLFPTAQYTKNGADIRLSVDVVEDMFRLPDITHVVIVAGDSDFIPLAQRCKRLGRHVVGIGVAGATSKQLAAACNEFAYYGELPGVEEEDDEERESPRERRSQRAPAAELAASAEPDASAERDASAEPAATAEAAADAASEPPQTSKRKAPASRRASSAGKKPAATEAVFSEPDGTTDAEREVAEEESAADSPDRGTDVTELLVRAMRLSHAKSDDEWLHSGGVKSQMQRMDPSFNEKALGFKSFSDFVKSRDSVVLVGKDDLAGRIKLRARARVKG
>NZ_CP017146.1|WP_161887023.1|3050657_3052163_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB
MAKVELMDYDRAIEMFEPVLGFEVHIELNTKTKMFSDAPNFFGGEPNTNITPVDLGLPGSLPVVNEQAIKYSISLGLALGCSIAPSSRFARKNYFYPDLAKNYQISQFDEPIAFDGNVEVELDDGRVFQISIERAHMEEDAGKLTHVGGSTGRIQGAEYSLVDYNRAGVPLVEIVTNIIYGAEKDAPELAKAYVSTIRDIVRSLDISDARMERGNLRCDANISLTPRGSGKLGTRTETKNVNSLRSVERAIRYEIQRQAAILATGGTITQETRHWHEDTGTTSAGRPKSDADDYRYFPEPDLLPVEPSLELIEELRAALPESPLLMRRRLKVDWGFSDIDFQSVVNAGLLVELVDTVSEGASPQSARKWWMGEISRTANEQGVDASSLVNAHQVAALVKLIDAGILTDRLARQVLEGVIAGEGTPAEVVASRGLAVVSDDTALIAAIDTALASQPDVLEKIRDGKLQAAGAVIGAVMKAMKGQADAARVRELVLERAGSAG
>NZ_CP017146.1|WP_161887024.1|3052162_3053701_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA
MPLTRMSAAELSQKLAAKEISSVEVTQAHLDRIAAVDGDVHAFLHISDAALSTAADVDSRRIDGELLGPLAGVPIAIKDVLCTIDMPSTAGSRILEGWVPPYDATVVRKLRHAHLVPLGKTNMDEFAMGSSTEHSAYGPTHNPWDLDRIPGGSGGGSAAAVAAFEAPLALGSDTGGSIRQPAAVTGSVGVKPTYGGVSRYGAIALASSLDQVGPVSRTVLDAALLHDVIGGHDPRDSTSLTDVWPCFADAARAGRTSRSLKGVRVGVVKELNGEGFQAGVRSRFAESLETMAAAGAEIVEVSAPNFEYAIAAYYLILPAEASSNLAKYDSVRFGLRVNPPGGGTVEDVMAATREAGFGDEVKRRIILGTYALSAGYYDAYYGSAQKVRTLIQRDFAAAFEQVDVLVSPSAPTTAFKLGEKLNDPLAMYLNDITTIPANLAGVPGMGLPMGLAPEDGLPTGLQIMAPARQDARLYSVGGALEALLEEKWGHTLISQAPRLEFTEMNAARGGVV
>NZ_CP017146.1|WP_161887025.1|3053700_3054000_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC
MSEITTEQVAHLAHLARIALTPQEIEKLTGELGTIVDSIAKVSQVAGEDVPATSHPIPLSNVFRPDVPGATLTTEEALAGAPEHDGSRFKVSAILGEEQ
>NZ_CP017146.1|WP_161887026.1|3054177_3054630_+|META-domain-containing-protein
MRSPTRQLAVSAALIGALALSGCAGVAGTTGESADGLHGQWLLVAGADKAGTIGLGHSAVTLSIDGEIGGGSTACNNYTIDLTGGPGAVEIAQIDNTGMICVPLSIMETERRYLAALATVTAAELAGDELRLTTDDIELRFVAWSNDVET
>NZ_CP017146.1|WP_161887027.1|3054650_3056063_-|hypothetical-protein
MLFGVAAILVTSVALSGATGALIVPESNAAANSYVIPTSQTAGYIYLGGTSPADSASAFFAPAQGLRTAPGSVNTELLPRLGGRALLDQLSLLHATDIAAFVSANPASVTKLLVNPPSAKSVNRWWSLASDSSRDAFLAGAPELAGNLDGLPMALRDEANRVVLSKSIAEAERTMPGLGRARQVDAAQRLHMLGEIRKSLVTRAGQPDRHLLQLDTVWPGRAAVVIGDLATADYVSYFVPGMFFSTDRLIVEWAVIAEDLYTEQTDWIARLGRTDAALRGKSVATVAWIGYETPGILDIASLDLAREGAKSISSAVDGVRATRQGDGPYLTLLTHSYGSTATLMALADGAMEVDALVLIGSPGSAAQSVDDIRMPSGRVFVGEAAWDPVTNSAFFGSDPGAPSFGAQTMSVAGGVDPITGRTLATATGHLGYFDIGTEAMRNMSLVGLDRGDLVTGADKATRGTLLAGGR
>NZ_CP017146.1|WP_161887028.1|3056205_3058482_-|NAD-dependent-DNA-ligase-LigA
MADTKAEFDAAKTEADGLTGRILELRDAYYERDTVLVSDDEYDSMLRRLQELERLFPELQSQDSPTQTIGGRAETTLFAPVRHADRMLSLDNVFSIDEFGAWATKVERDSGRQVRYLCELKIDGLAINLRYENGVLVTAATRGDGVVGEDVTENVAWVPSIPRRLAGSGHPPLVEVRGEVFFPVAAFLDLNAEQAAAGDRIFANPRNAASGSLRQKEESKTPPQVERMRRRLGRLSMLVHGIGAWQNPPVDAQSKVYELLATWGLPTSTHFRVLPSSGEVAEFIEYMGVHRDSVEHEIDGIVIKVDELALHEELGATSRAPRWAIAYKYPPEQVNTKLLDIVVSVGRTGRVTPFAVMQKVRVAGSEVRQATLHNQDVVKAKGVLIGDTVVLRKAGDVIPEVLGPVVELRDGTEREFIMPTECPECGTGLRAMKEGDIDLRCPNARSCPAQVRGRVEHIGSRGGLDIEGLGEVGAAALTQPLEPTDPPLVTEAGLFELQLRDIFPIRVLVRDSETGLVKLNDDGTPRQETPFRRKRRLTGKNPDPAFDPDDADAAAPPFAGDANYVPSTAATKLIAELELAKSKELWRFLVALSIRHVGPVAARALAAYFGSIEAIRGATRDELAAVDGVGGIIADSLIDWFAVDWHVEIIDRWRAAGVPFAIAGHPGPGAASAGGGVLDGLTVVATGSLEGFTREGALEAIIAAGGKAASSVSKKTDFVAAGPGAGSKLAKAEALGLRIIDAAQFAVLVTEGPSALDA
>NZ_CP017146.1|WP_161887029.1|3058557_3059706_-|tRNA-2-thiouridine(34)-synthase-MnmA
MKVLAAMSGGVDSAVAAARAVEAGHEVVGVHLALSRMPGTLRTGARGCCTIEDSMDAQRAANIIGIPYYVWDFSERFKLDVVDDFIAEYTAGRTPNPCMRCNERIKFAALLEKALDLGFDAVATGHYANIQTDADGNRELHRAADWAKDQSYVLGVLTSEQLAHSMFPLGATPSKAEVRAEAAARGFSVATKPDSHDICFIPDGDTRGWLAERVGAEQGVIRDRTGDVVGSHEGANAFTIGQRKGLNLGVPSADGRPRFVLEVKPASNEVVVGPREALDIAEVAGSKLSWAGLGPVDSGIIADAADPFDCFVQIRAHSEPVAAVARLVPRTGASEGQVELVIRPNVPLNGVAPGQTAVLYVGTRVLGQCTIDRTVSAVPVPA
>NZ_CP017146.1|WP_161887030.1|3059753_3060311_-|hypothetical-protein
MSRRIAGVVIGTALAVLLTGCVAGESPEPAASAPIAPSSSPEDESEPSPLLPVYPDGYTIDNVQAETERVAVRITGLVAVAGLLGQDTYSQEVENTEREGSYWGVLNTITLEPDVEAEIQAASVAADLADAGWLLVDGAQSPSDYAVALTSSEDPERAWFLVLGADLSVPGESVVTVRLSSPPLP
>NZ_CP017146.1|WP_161887031.1|3060303_3061464_-|cysteine-desulfurase
MAVYLDHAATTPMLGESIAAYTSALGIVGNPSSIHSQGQNAKRLLEEAREAVAASLGCDPIEVVFTSGGTESINLAIKGLYWARNSPGNRRPRILVPLGEHHATVDTVEWLERYEGAILEWLPLDSLGRVSVGAVADAFAAHDDIALVSLLMANNEVGTLQPVEQVVAIASAHGVPVHADAVSSYHRLPIDFAASGLAALSVSAHKIGGPLGIGALVLARSTTVVPLIHGGGQQRDVRSGTQDAPAAIAFGVAAQHPPVSLAPLRDRIIDGVRAAVPDAVLRGDPIDRLDNNAHFTFPGCEGDSLLFLLDVSGVSVSTGSACRAGIPEVSHVLRAMGVSDADARGALRMTLGHSSTEADVDAFLAALPAAYARARRAGFADRDVNE
>NZ_CP017146.1|WP_161887032.1|3061525_3063565_+|glycogen-debranching-protein-GlgX
MPETDMLRDLGVRATPEGGQVRVWSGSATAIEACVFAPNDPSWLAEKLQLTRDEHGVWSGASSRLVPGAHYSLRASGPTGPQHAFDKSLHLIDPYARGLARTNSGHWHSIVQDDAFDWAGARKPNTPLDHTVIYEAHAKGLSKLNPSIPERLRGTYAGLAHESNIAYLKDLGVTAIELLPVQQFVSEQRLIKQGLRNYWGYNTLGFFTPHAAYASRAAQVAGAAAVLREFKGMVKLLHEAGLEVILDVVYNHTAEEGPTGPTTSFRGLDNANYYRQMADGDYIDVTGCGNTLDFALPAAQRLVLDSLRYWANEVQIDGFRFDLAPALGRDDNVMFTPDHPLLHAIIDDPALQNVKMIAEPWDVGMGGWQVGNFPNGWEEWNDGYRDRMRDFWLTDVSSERLHGVAGQGIGSMARRLAGSAHVFSHERGPLASVNFITAHDGFTIADLTAYNQKHNLGNGENNRDGTDNNHSFNHGVEGPTGDPAVVAARCRAMRNLLGTLLLSGGVPMITAGDEFGRSQHGNNNAYCHDSTLTWLPWTKDPWQDELLDVSRRLLRLRRENPALRPVRFGVFGEKTPSSTQMDWFNADGATMSGENWDSPTARTLQYLAASTPELEEFNRILLIVHGLETPMTVTLPTHTGVSCYVLLWDSADDGAEGIELAPGAERVIAGTSMQLFRAL

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP017146_10	10.2|1209443|32|NZ_CP017146|CRISPRCasFinder	1209443-1209474	32	NZ_CP017146.1	1209481-1209512	0	1.0
NZ_CP017146_6	6.2|843128|20|NZ_CP017146|CRISPRCasFinder	843128-843147	20	NZ_CP017146.1	843164-843183	1	0.95

1. spacer 10.2|1209443|32|NZ_CP017146|CRISPRCasFinder matches to position: 1209481-1209512, mismatch: 0, identity: 1.0

atagcgcgttgtgcccgcgatagcgcgttgtg	CRISPR spacer
atagcgcgttgtgcccgcgatagcgcgttgtg	Protospacer
********************************

2. spacer 6.2|843128|20|NZ_CP017146|CRISPRCasFinder matches to position: 843164-843183, mismatch: 1, identity: 0.95

tcctggagccgatcctggag	CRISPR spacer
tcctgcagccgatcctggag	Protospacer
***** **************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP011665	Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence	136888-136909	0	1.0
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP024248	Escherichia coli O27:H7 strain B4103-1 plasmid unnamed3, complete sequence	108717-108738	0	1.0
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP011665	Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence	136879-136900	1	0.955
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NC_047783	Klebsiella phage vB_KpnP_KpV48, complete genome	15317-15338	1	0.955
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	MN694571	Marine virus AFVG_250M1012, complete genome	21793-21814	1	0.955
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	MN694571	Marine virus AFVG_250M1012, complete genome	21802-21823	1	0.955
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NC_049478	Arthrobacter phage Mufasa8, complete genome	6091-6112	1	0.955
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NC_025025	Mycobacterium tuberculosis H37Rv plasmid pTYGi9, complete sequence	4587-4608	1	0.955
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP016083	Streptomyces sp. SAT1 plasmid unnamed3, complete sequence	824585-824606	1	0.955
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NC_010879	Burkholderia glumae strain BGR1 plasmid pBGF2, complete sequence	10782-10803	1	0.955
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	KR063279	Gordonia phage GMA3, complete genome	52423-52444	1	0.955
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	MG592428	Vibrio phage 1.046.O._10N.286.52.E3, partial genome	44405-44426	1	0.955
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NC_031109	Gordonia phage Jumbo, complete genome	54644-54665	1	0.955
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP027299	Streptomyces sp. SGAir0924 plasmid unnamed_5	40119-40140	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	MG592428	Vibrio phage 1.046.O._10N.286.52.E3, partial genome	44396-44417	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	MG592428	Vibrio phage 1.046.O._10N.286.52.E3, partial genome	44435-44456	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NC_031109	Gordonia phage Jumbo, complete genome	54635-54656	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP016613	Ralstonia solanacearum FJAT-91 plasmid unnamed1, complete sequence	107500-107521	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP021449	Ralstonia solanacearum strain SEPPX05 plasmid pSEPPX05, complete sequence	883639-883660	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP021449	Ralstonia solanacearum strain SEPPX05 plasmid pSEPPX05, complete sequence	503897-503918	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP049790	Ralstonia solanacearum strain 202 plasmid unnamed, complete sequence	1558314-1558335	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP049788	Ralstonia solanacearum strain B2 plasmid unnamed, complete sequence	1401335-1401356	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP039340	Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence	419565-419586	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP025613	Niveispirillum cyanobacteriorum strain TH16 plasmid unnamed1, complete sequence	854375-854396	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_AP022571	Mycolicibacterium poriferae strain JCM 12603 plasmid pJCM12603, complete sequence	93790-93811	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP012940	Ralstonia solanacearum strain UW163 plasmid unnamed, complete sequence	1615162-1615183	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP012944	Ralstonia solanacearum strain IBSBF1503 plasmid unnamed, complete sequence	1486673-1486694	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP016915	Ralstonia solanacearum strain CQPS-1 plasmid unnamed, complete sequence	131490-131511	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP015851	Ralstonia solanacearum strain YC40-M plasmid, complete sequence	1659347-1659368	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP028965	Burkholderia sp. IDO3 plasmid p1, complete sequence	184373-184394	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NC_010802	Burkholderia multivorans ATCC 17616 plasmid pTGL1, complete sequence	100243-100264	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP042167	Burkholderia contaminans strain ZCC plasmid unnamed1, complete sequence	196516-196537	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022482	Ralstonia solanacearum strain HA4-1 plasmid HA4-1MP, complete sequence	551409-551430	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP023408	Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence	363925-363946	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP051295	Ralstonia solanacearum strain CIAT_078 plasmid megaplasmid, complete sequence	1598050-1598071	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022781	Ralstonia solanacearum strain SL3822 plasmid unnamed, complete sequence	1577903-1577924	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052111	Ralstonia solanacearum strain FJAT15244.F50 plasmid Plas1, complete sequence	1549352-1549373	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052113	Ralstonia solanacearum strain FJAT15244.F1 plasmid Plas1, complete sequence	1549352-1549373	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	KX856662	Klebsiella phage KP-Rio/2015, complete genome	15831-15852	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	KP708985	Klebsiella phage vB_KpnP_SU503, complete genome	16214-16235	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NC_028664	Klebsiella phage vB_Kp2, complete genome	15663-15684	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	MT701589	Klebsiella phage Pone, complete genome	15087-15108	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	MT682065	Klebsiella virus KpV2883, complete genome	14462-14483	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	MT360680	Klebsiella virus 2019KP1, complete genome	4975-4996	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	MN380459	Klebsiella phage vB_KpnP_fHeKpn01, complete genome	15775-15796	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	KX211991	Klebsiella phage vB_KpnP_KpV475, complete genome	14469-14490	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	GQ413938	Klebsiella phage KP34, complete genome	15789-15810	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NC_010070	Burkholderia multivorans ATCC 17616 plasmid pBMUL01, complete sequence	13222-13243	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022775	Ralstonia solanacearum strain T12 plasmid unnamed, complete sequence	573922-573943	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP010024	Paraburkholderia fungorum strain ATCC BAA-463 plasmid pBIL, complete sequence	165666-165687	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP026091	Ralstonia solanacearum strain IBSBF 2570 plasmid unnamed, complete sequence	386525-386546	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NC_014309	Ralstonia solanacearum CFBP2957 plasmid RCFBPv3_mp, complete genome	563222-563243	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	CP023013	Ralstonia solanacearum strain T110 plasmid unnamed, complete sequence	514450-514471	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP021653	Ralstonia solanacearum strain RS 488 plasmid unnamed, complete sequence	686737-686758	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NC_014310	Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence	563536-563557	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NC_012528	Deinococcus deserti VCD115 plasmid 3, complete sequence	291694-291715	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022762	Ralstonia solanacearum strain T95 plasmid unnamed, complete sequence	459486-459507	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NC_014838	Pantoea sp. At-9b plasmid pPAT9B01, complete sequence	700896-700917	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP049794	Ralstonia solanacearum strain 204 plasmid unnamed, complete sequence	1113543-1113564	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022766	Ralstonia solanacearum strain T78 plasmid unnamed, complete sequence	518722-518743	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP021763	Ralstonia pseudosolanacearum strain RS 476 plasmid unnamed, complete sequence	618050-618071	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP026093	Ralstonia solanacearum strain SFC plasmid unnamed, complete sequence	386538-386559	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP021767	Ralstonia solanacearum strain RS 489 plasmid unnamed, complete sequence	686715-686736	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP015116	Ralstonia solanacearum strain EP1 plasmid unnamed, complete sequence	679372-679393	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP030864	Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence	143494-143515	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP016555	Ralstonia solanacearum FJAT-1458 plasmid plas1, complete sequence	171846-171867	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP012688	Ralstonia solanacearum strain UY031 plasmid unnamed, complete sequence	686745-686766	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP049792	Ralstonia solanacearum strain 203 plasmid unnamed, complete sequence	895019-895040	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052069	Ralstonia solanacearum strain FJAT91.F50 plasmid Plas1, complete sequence	522538-522559	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP016905	Ralstonia solanacearum strain KACC 10709 plasmid unnamed1	1518640-1518661	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP025986	Ralstonia solanacearum strain RSCM plasmid p-unname2, complete sequence	758069-758090	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022769	Ralstonia solanacearum strain T60 plasmid unnamed, complete sequence	519985-520006	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP023017	Ralstonia solanacearum strain SL3022 plasmid unnamed, complete sequence	528837-528858	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022773	Ralstonia solanacearum strain T42 plasmid unnamed, complete sequence	531456-531477	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022783	Ralstonia solanacearum strain SL3755 plasmid unnamed, complete sequence	515917-515938	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022791	Ralstonia solanacearum strain SL3103 plasmid unnamed, complete sequence	416618-416639	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP028810	Burkholderia contaminans strain SK875 plasmid p875, complete sequence	9337-9358	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP014703	Ralstonia solanacearum strain KACC 10722 plasmid, complete sequence	459486-459507	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022760	Ralstonia solanacearum strain T98 plasmid unnamed, complete sequence	466725-466746	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022789	Ralstonia solanacearum strain SL3175 plasmid unnamed, complete sequence	466715-466736	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022795	Ralstonia solanacearum strain SL2330 plasmid unnamed, complete sequence	515010-515031	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052071	Ralstonia solanacearum strain FJAT454.F1 plasmid Plas1, complete sequence	533737-533758	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NC_017575	Ralstonia solanacearum Po82 megaplasmid, complete sequence	386338-386359	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022771	Ralstonia solanacearum strain T51 plasmid unnamed, complete sequence	459498-459519	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022777	Ralstonia solanacearum strain T11 plasmid unnamed, complete sequence	459518-459539	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022799	Ralstonia solanacearum strain SL2064 plasmid unnamed, complete sequence	459485-459506	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP009763	Ralstonia solanacearum OE1-1 plasmid unnamed, complete sequence	521441-521462	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	CP023015	Ralstonia solanacearum strain T25 plasmid unnamed, complete sequence	515640-515661	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022779	Ralstonia solanacearum strain SL3882 plasmid unnamed, complete sequence	520002-520023	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052075	Ralstonia solanacearum strain FJAT448.F1 plasmid Plas1, complete sequence	533737-533758	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052085	Ralstonia solanacearum strain FJAT15353.F8 plasmid Plas1, complete sequence	542667-542688	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052095	Ralstonia solanacearum strain FJAT15340.F1 plasmid Plas1, complete sequence	525143-525164	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052105	Ralstonia solanacearum strain FJAT15252.F1 plasmid Plas1, complete sequence	533735-533756	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP026308	Ralstonia solanacearum strain IBSBF 2571 plasmid unnamed, complete sequence	386334-386355	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP021765	Ralstonia pseudosolanacearum strain CRMRs218 plasmid unnamed, complete sequence	618080-618101	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052077	Ralstonia solanacearum strain FJAT445.F50 plasmid Plas1, complete sequence	513041-513062	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052087	Ralstonia solanacearum strain FJAT15353.F50 plasmid Plas1, complete sequence	542667-542688	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052097	Ralstonia solanacearum strain FJAT15304.F6 plasmid Plas1, complete sequence	525143-525164	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	CP047139	Ralstonia solanacearum strain CFBP 8695 plasmid unnamed, complete sequence	705888-705909	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052115	Ralstonia solanacearum strain FJAT1463.F50 plasmid Plas1, complete sequence	533737-533758	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052127	Ralstonia solanacearum strain FJAT1303.F50 plasmid Plas1, complete sequence	542667-542688	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	CP047137	Ralstonia solanacearum strain CFBP 8697 plasmid unnamed, complete sequence	672606-672627	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022764	Ralstonia solanacearum strain T82 plasmid unnamed, complete sequence	573965-573986	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052079	Ralstonia solanacearum strain FJAT445.F1 plasmid Plas1, complete sequence	513045-513066	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052089	Ralstonia solanacearum strain FJAT15353.F1 plasmid Plas1, complete sequence	542671-542692	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052093	Ralstonia solanacearum strain FJAT15340.F50 plasmid Plas1, complete sequence	525143-525164	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052101	Ralstonia solanacearum strain FJAT15304.F1 plasmid Plas1, complete sequence	525143-525164	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052099	Ralstonia solanacearum strain FJAT15304.F50 plasmid Plas1, complete sequence	525143-525164	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052107	Ralstonia solanacearum strain FJAT15249.F50 plasmid Plas1, complete sequence	533737-533758	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052117	Ralstonia solanacearum strain FJAT1463.F1 plasmid Plas1, complete sequence	533737-533758	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052125	Ralstonia solanacearum strain FJAT1452.F1 plasmid Plas1, complete sequence	513045-513066	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022793	Ralstonia solanacearum strain SL2729 plasmid unnamed, complete sequence	531439-531460	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022797	Ralstonia solanacearum strain SL2312 plasmid unnamed, complete sequence	573965-573986	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022785	Ralstonia solanacearum strain SL3730 plasmid unnamed, complete sequence	531392-531413	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022787	Ralstonia solanacearum strain SL3300 plasmid unnamed, complete sequence	565822-565843	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022756	Ralstonia solanacearum strain T117 plasmid unnamed, complete sequence	523216-523237	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052129	Ralstonia solanacearum strain FJAT1303.F1 plasmid Plas1, complete sequence	523654-523675	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052121	Ralstonia solanacearum strain FJAT1458.F1 plasmid Plas1, complete sequence	533737-533758	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052123	Ralstonia solanacearum strain FJAT1452.F50 plasmid Plas1, complete sequence	513045-513066	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052131	Ralstonia solanacearum strain FJAT1303.F8 plasmid Plas1, complete sequence	542667-542688	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	CP011998	Ralstonia solanacearum strain YC45 plasmid, complete sequence	612978-612999	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052073	Ralstonia solanacearum strain FJAT448.F50 plasmid Plas1, complete sequence	533734-533755	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052081	Ralstonia solanacearum strain FJAT442.F50 plasmid Plas1, complete sequence	513045-513066	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052083	Ralstonia solanacearum strain FJAT442.F1 plasmid Plas1, complete sequence	513045-513066	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052109	Ralstonia solanacearum strain FJAT15249.F1 plasmid Plas1, complete sequence	533737-533758	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052091	Ralstonia solanacearum strain FJAT15340.F6 plasmid Plas1, complete sequence	525145-525166	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052103	Ralstonia solanacearum strain FJAT15252.F50 plasmid Plas1, complete sequence	533737-533758	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP052119	Ralstonia solanacearum strain FJAT1458.F50 plasmid Plas1, complete sequence	533737-533758	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP022758	Ralstonia solanacearum strain T101 plasmid unnamed, complete sequence	573956-573977	2	0.909
NZ_CP017146_4	4.2|754715|22|NZ_CP017146|CRISPRCasFinder	754715-754736	22	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	425985-426006	3	0.864
NZ_CP017146_7	7.1|866103|32|NZ_CP017146|CRISPRCasFinder	866103-866134	32	MN855865	Myoviridae sp. isolate 346, complete genome	3251-3282	6	0.812
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	14906-14935	6	0.8
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP017759	Cupriavidus necator strain NH9 plasmid pENH92, complete sequence	293072-293101	6	0.8
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP020716	Cnuibacter physcomitrellae strain XA(T) plasmid unnamed1, complete sequence	26564-26593	6	0.8
NZ_CP017146_8	8.1|986696|29|NZ_CP017146|CRISPRCasFinder	986696-986724	29	NZ_CP046256	Sphingobium sp. CAP-1 plasmid p3, complete sequence	64159-64187	7	0.759
NZ_CP017146_8	8.1|986696|29|NZ_CP017146|CRISPRCasFinder	986696-986724	29	NZ_CP022748	Sphingobium hydrophobicum strain C1 plasmid p2, complete sequence	179402-179430	7	0.759
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP015867	Streptomyces parvulus strain 2297 plasmid pSPA1, complete sequence	162795-162824	7	0.767
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP047053	Clavibacter michiganensis subsp. michiganensis strain MSF322 plasmid pMSF1, complete sequence	13732-13761	7	0.767
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP010698	Phaeobacter inhibens strain P24 plasmid pP24_b, complete sequence	83077-83106	7	0.767
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	MK460245	Streptomyces phage BartholomewSD, complete genome	22990-23019	7	0.767
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	MN234208	Streptomyces phage Alvy, complete genome	22990-23019	7	0.767
NZ_CP017146_7	7.1|866103|32|NZ_CP017146|CRISPRCasFinder	866103-866134	32	NZ_AP023206	Escherichia coli strain TUM18781 plasmid pMTY18781-1_lncX3, complete sequence	74458-74489	8	0.75
NZ_CP017146_7	7.1|866103|32|NZ_CP017146|CRISPRCasFinder	866103-866134	32	NZ_LT703507	Mycobacterium chimaera strain Mycobacterium chimaera MC045 isolate Mycobacterium chimaera plasmid 3	91769-91800	8	0.75
NZ_CP017146_7	7.1|866103|32|NZ_CP017146|CRISPRCasFinder	866103-866134	32	NZ_LT703509	Mycobacterium chimaera strain Mycobacterium chimaera MC045 isolate Mycobacterium chimaera plasmid 5	19200-19231	8	0.75
NZ_CP017146_7	7.1|866103|32|NZ_CP017146|CRISPRCasFinder	866103-866134	32	NZ_CP015273	Mycobacterium chimaera strain ZUERICH-1 plasmid unnamed 1, complete sequence	90622-90653	8	0.75
NZ_CP017146_7	7.1|866103|32|NZ_CP017146|CRISPRCasFinder	866103-866134	32	NZ_CP015274	Mycobacterium chimaera strain ZUERICH-1 plasmid unnamed 2, complete sequence	35349-35380	8	0.75
NZ_CP017146_7	7.1|866103|32|NZ_CP017146|CRISPRCasFinder	866103-866134	32	NZ_CP019223	Mycobacterium chimaera strain CDC 2015-22-71 plasmid pDHQP20152271_2, complete sequence	270-301	8	0.75
NZ_CP017146_7	7.1|866103|32|NZ_CP017146|CRISPRCasFinder	866103-866134	32	NZ_CP019224	Mycobacterium chimaera strain CDC 2015-22-71 plasmid pDHQP20152271_1, complete sequence	71138-71169	8	0.75
NZ_CP017146_7	7.1|866103|32|NZ_CP017146|CRISPRCasFinder	866103-866134	32	NZ_CP045964	Mycobacterium chimaera strain AUSMDU00007395 plasmid pAUSMDU00007395_01, complete sequence	81865-81896	8	0.75
NZ_CP017146_7	7.1|866103|32|NZ_CP017146|CRISPRCasFinder	866103-866134	32	NZ_CP045965	Mycobacterium chimaera strain AUSMDU00007395 plasmid pAUSMDU00007395_02, complete sequence	26610-26641	8	0.75
NZ_CP017146_10	10.2|1209443|32|NZ_CP017146|CRISPRCasFinder	1209443-1209474	32	NZ_CP022775	Ralstonia solanacearum strain T12 plasmid unnamed, complete sequence	81192-81223	8	0.75
NZ_CP017146_10	10.2|1209443|32|NZ_CP017146|CRISPRCasFinder	1209443-1209474	32	NC_014310	Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence	79347-79378	8	0.75
NZ_CP017146_10	10.2|1209443|32|NZ_CP017146|CRISPRCasFinder	1209443-1209474	32	NZ_CP022762	Ralstonia solanacearum strain T95 plasmid unnamed, complete sequence	108883-108914	8	0.75
NZ_CP017146_10	10.2|1209443|32|NZ_CP017146|CRISPRCasFinder	1209443-1209474	32	NZ_CP023017	Ralstonia solanacearum strain SL3022 plasmid unnamed, complete sequence	81226-81257	8	0.75
NZ_CP017146_10	10.2|1209443|32|NZ_CP017146|CRISPRCasFinder	1209443-1209474	32	NZ_CP014703	Ralstonia solanacearum strain KACC 10722 plasmid, complete sequence	108883-108914	8	0.75
NZ_CP017146_10	10.2|1209443|32|NZ_CP017146|CRISPRCasFinder	1209443-1209474	32	NZ_CP022760	Ralstonia solanacearum strain T98 plasmid unnamed, complete sequence	81913-81944	8	0.75
NZ_CP017146_10	10.2|1209443|32|NZ_CP017146|CRISPRCasFinder	1209443-1209474	32	NZ_CP022789	Ralstonia solanacearum strain SL3175 plasmid unnamed, complete sequence	81913-81944	8	0.75
NZ_CP017146_10	10.2|1209443|32|NZ_CP017146|CRISPRCasFinder	1209443-1209474	32	NZ_CP022771	Ralstonia solanacearum strain T51 plasmid unnamed, complete sequence	108893-108924	8	0.75
NZ_CP017146_10	10.2|1209443|32|NZ_CP017146|CRISPRCasFinder	1209443-1209474	32	NZ_CP022777	Ralstonia solanacearum strain T11 plasmid unnamed, complete sequence	108912-108943	8	0.75
NZ_CP017146_10	10.2|1209443|32|NZ_CP017146|CRISPRCasFinder	1209443-1209474	32	NZ_CP022799	Ralstonia solanacearum strain SL2064 plasmid unnamed, complete sequence	108883-108914	8	0.75
NZ_CP017146_10	10.2|1209443|32|NZ_CP017146|CRISPRCasFinder	1209443-1209474	32	NZ_CP022764	Ralstonia solanacearum strain T82 plasmid unnamed, complete sequence	81204-81235	8	0.75
NZ_CP017146_10	10.2|1209443|32|NZ_CP017146|CRISPRCasFinder	1209443-1209474	32	NZ_CP022797	Ralstonia solanacearum strain SL2312 plasmid unnamed, complete sequence	81204-81235	8	0.75
NZ_CP017146_10	10.2|1209443|32|NZ_CP017146|CRISPRCasFinder	1209443-1209474	32	NZ_CP022758	Ralstonia solanacearum strain T101 plasmid unnamed, complete sequence	81202-81233	8	0.75
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_LR134459	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 17, complete sequence	146625-146654	8	0.733
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP015738	Shinella sp. HZN7 plasmid pShin-02, complete sequence	404224-404253	8	0.733
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP034351	Streptomyces sp. W1SF4 plasmid p1, complete sequence	425295-425324	8	0.733
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP019037	Massilia putida strain 6NM-7 plasmid unnamed2, complete sequence	226610-226639	8	0.733
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NC_019849	Sinorhizobium meliloti GR4 plasmid pRmeGR4d, complete sequence	532008-532037	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NC_017326	Sinorhizobium meliloti SM11 plasmid pSmeSM11d, complete sequence	520783-520812	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NC_017323	Sinorhizobium meliloti BL225C plasmid pSINMEB02, complete sequence	114633-114662	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP009146	Sinorhizobium meliloti strain RMO17 plasmid pSymB, complete sequence	525684-525713	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NC_018701	Sinorhizobium meliloti Rm41 plasmid pSYMB, complete sequence	518427-518456	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP021802	Sinorhizobium meliloti strain USDA1021 plasmid psymB, complete sequence	1185332-1185361	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP021820	Sinorhizobium meliloti strain M162 plasmid psymB, complete sequence	874116-874145	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP021831	Sinorhizobium meliloti strain HM006 plasmid psymB, complete sequence	778782-778811	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP021814	Sinorhizobium meliloti strain M270 plasmid psymB, complete sequence	404465-404494	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP021810	Sinorhizobium meliloti strain Rm41 plasmid psymB, complete sequence	1307220-1307249	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP021218	Sinorhizobium meliloti RU11/001 plasmid pSymB, complete sequence	671385-671414	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP026527	Sinorhizobium meliloti strain AK21 plasmid pSymB, complete sequence	542221-542250	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NC_003078	Sinorhizobium meliloti 1021 plasmid pSymB, complete sequence	1201204-1201233	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP019586	Sinorhizobium meliloti strain CCMM B554 (FSM-MA) plasmid pSymB, complete sequence	1171697-1171726	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP021799	Sinorhizobium meliloti strain USDA1106 plasmid psymB, complete sequence	1267427-1267456	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP021828	Sinorhizobium meliloti strain KH35c plasmid psymB, complete sequence	774142-774171	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP021823	Sinorhizobium meliloti strain KH46 plasmid psymB, complete sequence	889895-889924	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP021795	Sinorhizobium meliloti strain USDA1157 plasmid psymB, complete sequence	411511-411540	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP021806	Sinorhizobium meliloti strain T073 plasmid psymB, complete sequence	489232-489261	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP019484	Sinorhizobium meliloti strain B401 plasmid pSymB, complete sequence	1341944-1341973	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP019487	Sinorhizobium meliloti strain B399 plasmid pSym, complete sequence	1114244-1114273	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NC_020560	Sinorhizobium meliloti 2011 plasmid pSymB, complete sequence	1201210-1201239	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_LR723678	Arsenite-oxidising bacterium NT-25 plasmid 2	165934-165963	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP029357	Azospirillum sp. CFH 70021 plasmid unnamed2	637504-637533	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_FO082821	Rhizobium sp. NT-26 plasmid NT26_p1, complete sequence	247155-247184	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	MN850628	Escherichia phage bob, complete genome	16719-16748	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	MN850629	Escherichia phage mckay, complete genome	21477-21506	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NZ_CP032676	Rhodococcus rhodochrous strain ATCC BAA870 plasmid pNit, complete sequence	298072-298101	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NC_004808	Streptomyces rochei plasmid pSLA2-L DNA, complete sequence	110030-110059	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	NC_012223	Enterobacteria phage SSL2009a, complete genome	14946-14975	9	0.7
NZ_CP017146_12	12.1|1856607|30|NZ_CP017146|CRISPRCasFinder	1856607-1856636	30	FJ750948	Enterobacteria phage SSL-2009a, complete genome	14946-14975	9	0.7
NZ_CP017146_7	7.1|866103|32|NZ_CP017146|CRISPRCasFinder	866103-866134	32	NZ_CP014169	Sphingomonas panacis strain DCY99 plasmid unnamed, complete sequence	198997-199028	10	0.688

1. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP011665 (Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence) position: , mismatch: 0, identity: 1.0

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgccggtgctgccggtgctgc	Protospacer
**********************

2. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP024248 (Escherichia coli O27:H7 strain B4103-1 plasmid unnamed3, complete sequence) position: , mismatch: 0, identity: 1.0

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgccggtgctgccggtgctgc	Protospacer
**********************

3. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP011665 (Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence) position: , mismatch: 1, identity: 0.955

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgccggtgctgccggtactgc	Protospacer
*****************.****

4. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NC_047783 (Klebsiella phage vB_KpnP_KpV48, complete genome) position: , mismatch: 1, identity: 0.955

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgccggtgctgctggtgctgc	Protospacer
*************.********

5. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to MN694571 (Marine virus AFVG_250M1012, complete genome) position: , mismatch: 1, identity: 0.955

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgccggtgctgcccgtgctgc	Protospacer
************** *******

6. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to MN694571 (Marine virus AFVG_250M1012, complete genome) position: , mismatch: 1, identity: 0.955

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgcccgtgctgccggtgctgc	Protospacer
***** ****************

7. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NC_049478 (Arthrobacter phage Mufasa8, complete genome) position: , mismatch: 1, identity: 0.955

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgccggtgctgccggtgcggc	Protospacer
******************* **

8. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NC_025025 (Mycobacterium tuberculosis H37Rv plasmid pTYGi9, complete sequence) position: , mismatch: 1, identity: 0.955

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgccggtgccgccggtgctgc	Protospacer
**********.***********

9. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP016083 (Streptomyces sp. SAT1 plasmid unnamed3, complete sequence) position: , mismatch: 1, identity: 0.955

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgccggtgccgccggtgctgc	Protospacer
**********.***********

10. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NC_010879 (Burkholderia glumae strain BGR1 plasmid pBGF2, complete sequence) position: , mismatch: 1, identity: 0.955

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgccggtgctggcggtgctgc	Protospacer
************ *********

11. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to KR063279 (Gordonia phage GMA3, complete genome) position: , mismatch: 1, identity: 0.955

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgccggtgcttccggtgctgc	Protospacer
*********** **********

12. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to MG592428 (Vibrio phage 1.046.O._10N.286.52.E3, partial genome) position: , mismatch: 1, identity: 0.955

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgccggtgctgcgggtgctgc	Protospacer
************* ********

13. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NC_031109 (Gordonia phage Jumbo, complete genome) position: , mismatch: 1, identity: 0.955

ctgccggtgctgccggtgctgc	CRISPR spacer
ccgccggtgctgccggtgctgc	Protospacer
*.********************

14. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP027299 (Streptomyces sp. SGAir0924 plasmid unnamed_5) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
gggccggtgctgccggtgctgc	Protospacer
  ********************

15. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to MG592428 (Vibrio phage 1.046.O._10N.286.52.E3, partial genome) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
cgcccggtgctgccggtgctgc	Protospacer
*  *******************

16. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to MG592428 (Vibrio phage 1.046.O._10N.286.52.E3, partial genome) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
cgcccggtgctgccggtgctgc	Protospacer
*  *******************

17. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NC_031109 (Gordonia phage Jumbo, complete genome) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ttgccggtgccgccggtgctgc	Protospacer
.*********.***********

18. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP016613 (Ralstonia solanacearum FJAT-91 plasmid unnamed1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

19. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP021449 (Ralstonia solanacearum strain SEPPX05 plasmid pSEPPX05, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
gtgccggtgcagccggtgctgc	Protospacer
 ********* ***********

20. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP021449 (Ralstonia solanacearum strain SEPPX05 plasmid pSEPPX05, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

21. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP049790 (Ralstonia solanacearum strain 202 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

22. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP049788 (Ralstonia solanacearum strain B2 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

23. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP039340 (Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

24. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP025613 (Niveispirillum cyanobacteriorum strain TH16 plasmid unnamed1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ttgccggtgctgctggtgctgc	Protospacer
.************.********

25. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_AP022571 (Mycolicibacterium poriferae strain JCM 12603 plasmid pJCM12603, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
gtgccggtgctgccggtgttgc	Protospacer
 *****************.***

26. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP012940 (Ralstonia solanacearum strain UW163 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

27. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP012944 (Ralstonia solanacearum strain IBSBF1503 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

28. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP016915 (Ralstonia solanacearum strain CQPS-1 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

29. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP015851 (Ralstonia solanacearum strain YC40-M plasmid, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

30. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP028965 (Burkholderia sp. IDO3 plasmid p1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

31. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NC_010802 (Burkholderia multivorans ATCC 17616 plasmid pTGL1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

32. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP042167 (Burkholderia contaminans strain ZCC plasmid unnamed1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

33. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022482 (Ralstonia solanacearum strain HA4-1 plasmid HA4-1MP, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

34. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP023408 (Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
gtgccggtgctgacggtgctgc	Protospacer
 *********** *********

35. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP051295 (Ralstonia solanacearum strain CIAT_078 plasmid megaplasmid, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

36. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022781 (Ralstonia solanacearum strain SL3822 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

37. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052111 (Ralstonia solanacearum strain FJAT15244.F50 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

38. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052113 (Ralstonia solanacearum strain FJAT15244.F1 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

39. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to KX856662 (Klebsiella phage KP-Rio/2015, complete genome) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
caaccggtgctgccggtgctgc	Protospacer
* .*******************

40. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to KP708985 (Klebsiella phage vB_KpnP_SU503, complete genome) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
caaccggtgctgccggtgctgc	Protospacer
* .*******************

41. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NC_028664 (Klebsiella phage vB_Kp2, complete genome) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
caaccggtgctgccggtgctgc	Protospacer
* .*******************

42. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to MT701589 (Klebsiella phage Pone, complete genome) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
caaccggtgctgccggtgctgc	Protospacer
* .*******************

43. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to MT682065 (Klebsiella virus KpV2883, complete genome) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
caaccggtgctgccggtgctgc	Protospacer
* .*******************

44. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to MT360680 (Klebsiella virus 2019KP1, complete genome) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
caaccggtgctgccggtgctgc	Protospacer
* .*******************

45. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to MN380459 (Klebsiella phage vB_KpnP_fHeKpn01, complete genome) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
caaccggtgctgccggtgctgc	Protospacer
* .*******************

46. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to KX211991 (Klebsiella phage vB_KpnP_KpV475, complete genome) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
caaccggtgctgccggtgctgc	Protospacer
* .*******************

47. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to GQ413938 (Klebsiella phage KP34, complete genome) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
caaccggtgctgccggtgctgc	Protospacer
* .*******************

48. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NC_010070 (Burkholderia multivorans ATCC 17616 plasmid pBMUL01, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

49. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022775 (Ralstonia solanacearum strain T12 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

50. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP010024 (Paraburkholderia fungorum strain ATCC BAA-463 plasmid pBIL, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgccggtgctgccggagctga	Protospacer
**************** **** 

51. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP026091 (Ralstonia solanacearum strain IBSBF 2570 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

52. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NC_014309 (Ralstonia solanacearum CFBP2957 plasmid RCFBPv3_mp, complete genome) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

53. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to CP023013 (Ralstonia solanacearum strain T110 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

54. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP021653 (Ralstonia solanacearum strain RS 488 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

55. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NC_014310 (Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

56. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NC_012528 (Deinococcus deserti VCD115 plasmid 3, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgacggtgctgccggtgctga	Protospacer
*** ***************** 

57. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022762 (Ralstonia solanacearum strain T95 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

58. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NC_014838 (Pantoea sp. At-9b plasmid pPAT9B01, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

59. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP049794 (Ralstonia solanacearum strain 204 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

60. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022766 (Ralstonia solanacearum strain T78 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

61. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP021763 (Ralstonia pseudosolanacearum strain RS 476 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

62. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP026093 (Ralstonia solanacearum strain SFC plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

63. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP021767 (Ralstonia solanacearum strain RS 489 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

64. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP015116 (Ralstonia solanacearum strain EP1 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

65. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP030864 (Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
gtgccggtggtgccggtgctgc	Protospacer
 ******** ************

66. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP016555 (Ralstonia solanacearum FJAT-1458 plasmid plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

67. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP012688 (Ralstonia solanacearum strain UY031 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

68. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP049792 (Ralstonia solanacearum strain 203 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

69. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052069 (Ralstonia solanacearum strain FJAT91.F50 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

70. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP016905 (Ralstonia solanacearum strain KACC 10709 plasmid unnamed1) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

71. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP025986 (Ralstonia solanacearum strain RSCM plasmid p-unname2, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

72. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022769 (Ralstonia solanacearum strain T60 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

73. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP023017 (Ralstonia solanacearum strain SL3022 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

74. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022773 (Ralstonia solanacearum strain T42 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

75. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022783 (Ralstonia solanacearum strain SL3755 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

76. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022791 (Ralstonia solanacearum strain SL3103 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

77. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP028810 (Burkholderia contaminans strain SK875 plasmid p875, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

78. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP014703 (Ralstonia solanacearum strain KACC 10722 plasmid, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

79. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022760 (Ralstonia solanacearum strain T98 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

80. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022789 (Ralstonia solanacearum strain SL3175 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

81. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022795 (Ralstonia solanacearum strain SL2330 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

82. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052071 (Ralstonia solanacearum strain FJAT454.F1 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

83. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NC_017575 (Ralstonia solanacearum Po82 megaplasmid, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

84. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022771 (Ralstonia solanacearum strain T51 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

85. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022777 (Ralstonia solanacearum strain T11 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

86. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022799 (Ralstonia solanacearum strain SL2064 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

87. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP009763 (Ralstonia solanacearum OE1-1 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

88. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to CP023015 (Ralstonia solanacearum strain T25 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

89. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022779 (Ralstonia solanacearum strain SL3882 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

90. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052075 (Ralstonia solanacearum strain FJAT448.F1 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

91. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052085 (Ralstonia solanacearum strain FJAT15353.F8 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

92. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052095 (Ralstonia solanacearum strain FJAT15340.F1 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

93. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052105 (Ralstonia solanacearum strain FJAT15252.F1 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

94. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP026308 (Ralstonia solanacearum strain IBSBF 2571 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

95. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP021765 (Ralstonia pseudosolanacearum strain CRMRs218 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

96. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052077 (Ralstonia solanacearum strain FJAT445.F50 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

97. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052087 (Ralstonia solanacearum strain FJAT15353.F50 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

98. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052097 (Ralstonia solanacearum strain FJAT15304.F6 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

99. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to CP047139 (Ralstonia solanacearum strain CFBP 8695 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

100. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052115 (Ralstonia solanacearum strain FJAT1463.F50 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

101. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052127 (Ralstonia solanacearum strain FJAT1303.F50 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

102. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to CP047137 (Ralstonia solanacearum strain CFBP 8697 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

103. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022764 (Ralstonia solanacearum strain T82 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

104. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052079 (Ralstonia solanacearum strain FJAT445.F1 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

105. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052089 (Ralstonia solanacearum strain FJAT15353.F1 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

106. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052093 (Ralstonia solanacearum strain FJAT15340.F50 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

107. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052101 (Ralstonia solanacearum strain FJAT15304.F1 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

108. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052099 (Ralstonia solanacearum strain FJAT15304.F50 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

109. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052107 (Ralstonia solanacearum strain FJAT15249.F50 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

110. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052117 (Ralstonia solanacearum strain FJAT1463.F1 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

111. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052125 (Ralstonia solanacearum strain FJAT1452.F1 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

112. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022793 (Ralstonia solanacearum strain SL2729 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

113. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022797 (Ralstonia solanacearum strain SL2312 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

114. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022785 (Ralstonia solanacearum strain SL3730 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

115. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022787 (Ralstonia solanacearum strain SL3300 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

116. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022756 (Ralstonia solanacearum strain T117 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

117. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052129 (Ralstonia solanacearum strain FJAT1303.F1 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

118. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052121 (Ralstonia solanacearum strain FJAT1458.F1 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

119. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052123 (Ralstonia solanacearum strain FJAT1452.F50 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

120. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052131 (Ralstonia solanacearum strain FJAT1303.F8 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

121. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to CP011998 (Ralstonia solanacearum strain YC45 plasmid, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

122. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052073 (Ralstonia solanacearum strain FJAT448.F50 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

123. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052081 (Ralstonia solanacearum strain FJAT442.F50 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

124. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052083 (Ralstonia solanacearum strain FJAT442.F1 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

125. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052109 (Ralstonia solanacearum strain FJAT15249.F1 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

126. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052091 (Ralstonia solanacearum strain FJAT15340.F6 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

127. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052103 (Ralstonia solanacearum strain FJAT15252.F50 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

128. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP052119 (Ralstonia solanacearum strain FJAT1458.F50 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

129. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022758 (Ralstonia solanacearum strain T101 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

ctgccggtgctgccggtgctgc	CRISPR spacer
ctgctggtgctgccggtgctgt	Protospacer
****.****************.

130. spacer 4.2|754715|22|NZ_CP017146|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 3, identity: 0.864

ctgccggtgctgccggtgctgc	CRISPR spacer
gcgccggtgctgccggtgctgg	Protospacer
 .******************* 

131. spacer 7.1|866103|32|NZ_CP017146|CRISPRCasFinder matches to MN855865 (Myoviridae sp. isolate 346, complete genome) position: , mismatch: 6, identity: 0.812

gcgccagcggtcgctgaccgtcgacg-agcact	CRISPR spacer
gcgccggcggtcgctggccgtcgatactgcac-	Protospacer
*****.**********.*******..  **** 

132. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 6, identity: 0.8

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
aagccgcgagctcgggatgctcggcggcgc	Protospacer
 .******** ******** ******  **

133. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP017759 (Cupriavidus necator strain NH9 plasmid pENH92, complete sequence) position: , mismatch: 6, identity: 0.8

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
tgtccgcgagggcgggatggtcggtttgga	Protospacer
** ******** ************. *.* 

134. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP020716 (Cnuibacter physcomitrellae strain XA(T) plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.8

tggcc--gcgaggtcgggatggtcggcgtagc	CRISPR spacer
--accaggcagggtcgggctggtcggcgtagc	Protospacer
  .**  **..******* *************

135. spacer 8.1|986696|29|NZ_CP017146|CRISPRCasFinder matches to NZ_CP046256 (Sphingobium sp. CAP-1 plasmid p3, complete sequence) position: , mismatch: 7, identity: 0.759

gagtaacgcgcttgcgcgggctgcggatg	CRISPR spacer
gcgggcgccgcttgcgcggtctgcggatg	Protospacer
* * .   *********** *********

136. spacer 8.1|986696|29|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022748 (Sphingobium hydrophobicum strain C1 plasmid p2, complete sequence) position: , mismatch: 7, identity: 0.759

gagtaacgcgcttgcgcgggctgcggatg	CRISPR spacer
gcgggcgccgcttgcgcggtctgcggatg	Protospacer
* * .   *********** *********

137. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP015867 (Streptomyces parvulus strain 2297 plasmid pSPA1, complete sequence) position: , mismatch: 7, identity: 0.767

tggccgcgaggtcgggatggtcggcgtagc-	CRISPR spacer
gcgccgcgaggtcggggtggtc-gtacagcg	Protospacer
  **************.***** *...*** 

138. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP047053 (Clavibacter michiganensis subsp. michiganensis strain MSF322 plasmid pMSF1, complete sequence) position: , mismatch: 7, identity: 0.767

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
gggccgcaaggtcgcgatggtcggtgacgg	Protospacer
 ******.****** *********.*  * 

139. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP010698 (Phaeobacter inhibens strain P24 plasmid pP24_b, complete sequence) position: , mismatch: 7, identity: 0.767

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
tgacatcgaggtcggcatggtcggcgtcaa	Protospacer
**.*  ********* *********** . 

140. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to MK460245 (Streptomyces phage BartholomewSD, complete genome) position: , mismatch: 7, identity: 0.767

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cggccgcgacctcgggatggtcggtgccga	Protospacer
.********  *************.*. * 

141. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to MN234208 (Streptomyces phage Alvy, complete genome) position: , mismatch: 7, identity: 0.767

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cggccgcgacctcgggatggtcggtgccga	Protospacer
.********  *************.*. * 

142. spacer 7.1|866103|32|NZ_CP017146|CRISPRCasFinder matches to NZ_AP023206 (Escherichia coli strain TUM18781 plasmid pMTY18781-1_lncX3, complete sequence) position: , mismatch: 8, identity: 0.75

gcgccagcggtcgctgaccgtcgacgagcact	CRISPR spacer
ccgccagcggacgctgaccgtctacctggtcg	Protospacer
 ********* *********** **  *  * 

143. spacer 7.1|866103|32|NZ_CP017146|CRISPRCasFinder matches to NZ_LT703507 (Mycobacterium chimaera strain Mycobacterium chimaera MC045 isolate Mycobacterium chimaera plasmid 3) position: , mismatch: 8, identity: 0.75

gcgccagcggtcgctgaccgtcgacgagcact	CRISPR spacer
gcagcagcggtcgctgcccgtcgccgatggcg	Protospacer
**. ************ ****** ***  .* 

144. spacer 7.1|866103|32|NZ_CP017146|CRISPRCasFinder matches to NZ_LT703509 (Mycobacterium chimaera strain Mycobacterium chimaera MC045 isolate Mycobacterium chimaera plasmid 5) position: , mismatch: 8, identity: 0.75

gcgccagcggtcgctgaccgtcgacgagcact	CRISPR spacer
gcagcagcggtcgctgcccgtcgccgatggcg	Protospacer
**. ************ ****** ***  .* 

145. spacer 7.1|866103|32|NZ_CP017146|CRISPRCasFinder matches to NZ_CP015273 (Mycobacterium chimaera strain ZUERICH-1 plasmid unnamed 1, complete sequence) position: , mismatch: 8, identity: 0.75

gcgccagcggtcgctgaccgtcgacgagcact	CRISPR spacer
gcagcagcggtcgctgcccgtcgccgatggcg	Protospacer
**. ************ ****** ***  .* 

146. spacer 7.1|866103|32|NZ_CP017146|CRISPRCasFinder matches to NZ_CP015274 (Mycobacterium chimaera strain ZUERICH-1 plasmid unnamed 2, complete sequence) position: , mismatch: 8, identity: 0.75

gcgccagcggtcgctgaccgtcgacgagcact	CRISPR spacer
gcagcagcggtcgctgcccgtcgccgatggcg	Protospacer
**. ************ ****** ***  .* 

147. spacer 7.1|866103|32|NZ_CP017146|CRISPRCasFinder matches to NZ_CP019223 (Mycobacterium chimaera strain CDC 2015-22-71 plasmid pDHQP20152271_2, complete sequence) position: , mismatch: 8, identity: 0.75

gcgccagcggtcgctgaccgtcgacgagcact	CRISPR spacer
gcagcagcggtcgctgcccgtcgccgatggcg	Protospacer
**. ************ ****** ***  .* 

148. spacer 7.1|866103|32|NZ_CP017146|CRISPRCasFinder matches to NZ_CP019224 (Mycobacterium chimaera strain CDC 2015-22-71 plasmid pDHQP20152271_1, complete sequence) position: , mismatch: 8, identity: 0.75

gcgccagcggtcgctgaccgtcgacgagcact	CRISPR spacer
gcagcagcggtcgctgcccgtcgccgatggcg	Protospacer
**. ************ ****** ***  .* 

149. spacer 7.1|866103|32|NZ_CP017146|CRISPRCasFinder matches to NZ_CP045964 (Mycobacterium chimaera strain AUSMDU00007395 plasmid pAUSMDU00007395_01, complete sequence) position: , mismatch: 8, identity: 0.75

gcgccagcggtcgctgaccgtcgacgagcact	CRISPR spacer
gcagcagcggtcgctgcccgtcgccgatggcg	Protospacer
**. ************ ****** ***  .* 

150. spacer 7.1|866103|32|NZ_CP017146|CRISPRCasFinder matches to NZ_CP045965 (Mycobacterium chimaera strain AUSMDU00007395 plasmid pAUSMDU00007395_02, complete sequence) position: , mismatch: 8, identity: 0.75

gcgccagcggtcgctgaccgtcgacgagcact	CRISPR spacer
gcagcagcggtcgctgcccgtcgccgatggcg	Protospacer
**. ************ ****** ***  .* 

151. spacer 10.2|1209443|32|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022775 (Ralstonia solanacearum strain T12 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.75

atagcgcgttgtgcccgcgatagcgcgttgtg	CRISPR spacer
agcgcgcgttgtgcctgcgacagcgcggccgg	Protospacer
*  ************.****.****** .  *

152. spacer 10.2|1209443|32|NZ_CP017146|CRISPRCasFinder matches to NC_014310 (Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence) position: , mismatch: 8, identity: 0.75

atagcgcgttgtgcccgcgatagcgcgttgtg	CRISPR spacer
agcgcgcgttgtgcctgcgacagcgcggccgg	Protospacer
*  ************.****.****** .  *

153. spacer 10.2|1209443|32|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022762 (Ralstonia solanacearum strain T95 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.75

atagcgcgttgtgcccgcgatagcgcgttgtg	CRISPR spacer
agcgcgcgttgtgcctgcgacagcgcggccgg	Protospacer
*  ************.****.****** .  *

154. spacer 10.2|1209443|32|NZ_CP017146|CRISPRCasFinder matches to NZ_CP023017 (Ralstonia solanacearum strain SL3022 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.75

atagcgcgttgtgcccgcgatagcgcgttgtg	CRISPR spacer
agcgcgcgttgtgcctgcgacagcgcggccgg	Protospacer
*  ************.****.****** .  *

155. spacer 10.2|1209443|32|NZ_CP017146|CRISPRCasFinder matches to NZ_CP014703 (Ralstonia solanacearum strain KACC 10722 plasmid, complete sequence) position: , mismatch: 8, identity: 0.75

atagcgcgttgtgcccgcgatagcgcgttgtg	CRISPR spacer
agcgcgcgttgtgcctgcgacagcgcggccgg	Protospacer
*  ************.****.****** .  *

156. spacer 10.2|1209443|32|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022760 (Ralstonia solanacearum strain T98 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.75

atagcgcgttgtgcccgcgatagcgcgttgtg	CRISPR spacer
agcgcgcgttgtgcctgcgacagcgcggccgg	Protospacer
*  ************.****.****** .  *

157. spacer 10.2|1209443|32|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022789 (Ralstonia solanacearum strain SL3175 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.75

atagcgcgttgtgcccgcgatagcgcgttgtg	CRISPR spacer
agcgcgcgttgtgcctgcgacagcgcggccgg	Protospacer
*  ************.****.****** .  *

158. spacer 10.2|1209443|32|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022771 (Ralstonia solanacearum strain T51 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.75

atagcgcgttgtgcccgcgatagcgcgttgtg	CRISPR spacer
agcgcgcgttgtgcctgcgacagcgcggccgg	Protospacer
*  ************.****.****** .  *

159. spacer 10.2|1209443|32|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022777 (Ralstonia solanacearum strain T11 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.75

atagcgcgttgtgcccgcgatagcgcgttgtg	CRISPR spacer
agcgcgcgttgtgcctgcgacagcgcggccgg	Protospacer
*  ************.****.****** .  *

160. spacer 10.2|1209443|32|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022799 (Ralstonia solanacearum strain SL2064 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.75

atagcgcgttgtgcccgcgatagcgcgttgtg	CRISPR spacer
agcgcgcgttgtgcctgcgacagcgcggccgg	Protospacer
*  ************.****.****** .  *

161. spacer 10.2|1209443|32|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022764 (Ralstonia solanacearum strain T82 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.75

atagcgcgttgtgcccgcgatagcgcgttgtg	CRISPR spacer
agcgcgcgttgtgcctgcgacagcgcggccgg	Protospacer
*  ************.****.****** .  *

162. spacer 10.2|1209443|32|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022797 (Ralstonia solanacearum strain SL2312 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.75

atagcgcgttgtgcccgcgatagcgcgttgtg	CRISPR spacer
agcgcgcgttgtgcctgcgacagcgcggccgg	Protospacer
*  ************.****.****** .  *

163. spacer 10.2|1209443|32|NZ_CP017146|CRISPRCasFinder matches to NZ_CP022758 (Ralstonia solanacearum strain T101 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.75

atagcgcgttgtgcccgcgatagcgcgttgtg	CRISPR spacer
agcgcgcgttgtgcctgcgacagcgcggccgg	Protospacer
*  ************.****.****** .  *

164. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_LR134459 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 17, complete sequence) position: , mismatch: 8, identity: 0.733

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
ccgcgtcgaggtcggcatggtcggcgtcaa	Protospacer
. **  ********* *********** . 

165. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP015738 (Shinella sp. HZN7 plasmid pShin-02, complete sequence) position: , mismatch: 8, identity: 0.733

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
tggccgcgccgtcgggatggtcgagccgga	Protospacer
********  *************.  ..* 

166. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP034351 (Streptomyces sp. W1SF4 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.733

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
tgcccgcgaggccgggatggtcgaggagct	Protospacer
** ********.***********. * . .

167. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP019037 (Massilia putida strain 6NM-7 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.733

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
agcccgcgaggtcggcatagtcggcggtcg	Protospacer
 * ************ **.*******    

168. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NC_019849 (Sinorhizobium meliloti GR4 plasmid pRmeGR4d, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

169. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NC_017326 (Sinorhizobium meliloti SM11 plasmid pSmeSM11d, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

170. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NC_017323 (Sinorhizobium meliloti BL225C plasmid pSINMEB02, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

171. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP009146 (Sinorhizobium meliloti strain RMO17 plasmid pSymB, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

172. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NC_018701 (Sinorhizobium meliloti Rm41 plasmid pSYMB, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

173. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP021802 (Sinorhizobium meliloti strain USDA1021 plasmid psymB, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

174. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP021820 (Sinorhizobium meliloti strain M162 plasmid psymB, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

175. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP021831 (Sinorhizobium meliloti strain HM006 plasmid psymB, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

176. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP021814 (Sinorhizobium meliloti strain M270 plasmid psymB, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

177. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP021810 (Sinorhizobium meliloti strain Rm41 plasmid psymB, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

178. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP021218 (Sinorhizobium meliloti RU11/001 plasmid pSymB, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

179. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP026527 (Sinorhizobium meliloti strain AK21 plasmid pSymB, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

180. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NC_003078 (Sinorhizobium meliloti 1021 plasmid pSymB, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

181. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP019586 (Sinorhizobium meliloti strain CCMM B554 (FSM-MA) plasmid pSymB, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

182. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP021799 (Sinorhizobium meliloti strain USDA1106 plasmid psymB, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

183. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP021828 (Sinorhizobium meliloti strain KH35c plasmid psymB, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

184. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP021823 (Sinorhizobium meliloti strain KH46 plasmid psymB, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

185. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP021795 (Sinorhizobium meliloti strain USDA1157 plasmid psymB, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

186. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP021806 (Sinorhizobium meliloti strain T073 plasmid psymB, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

187. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP019484 (Sinorhizobium meliloti strain B401 plasmid pSymB, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

188. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP019487 (Sinorhizobium meliloti strain B399 plasmid pSym, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

189. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NC_020560 (Sinorhizobium meliloti 2011 plasmid pSymB, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cccaggcgaggtcgggatgggcggcgtcct	Protospacer
.    *************** ******  .

190. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_LR723678 (Arsenite-oxidising bacterium NT-25 plasmid 2) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
gaagctcgaggccgggatggtcggcgtcaa	Protospacer
 .. * *****.*************** . 

191. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP029357 (Azospirillum sp. CFH 70021 plasmid unnamed2) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
ggagatcgaggtcggcatggtcggcgtcaa	Protospacer
 *.   ********* *********** . 

192. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_FO082821 (Rhizobium sp. NT-26 plasmid NT26_p1, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
gaagctcgaggccgggatggtcggcgtcaa	Protospacer
 .. * *****.*************** . 

193. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to MN850628 (Escherichia phage bob, complete genome) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cttgagcgaggtcgggaaggtccgcgtatt	Protospacer
.    ************ **** ***** .

194. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to MN850629 (Escherichia phage mckay, complete genome) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cttgagcgaggtcgggaaggtccgcgtatt	Protospacer
.    ************ **** ***** .

195. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NZ_CP032676 (Rhodococcus rhodochrous strain ATCC BAA870 plasmid pNit, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cgaagtcgaggtcggtatggtcggcgtcaa	Protospacer
.*.   ********* *********** . 

196. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NC_004808 (Streptomyces rochei plasmid pSLA2-L DNA, complete sequence) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
gcagcgcgaggtcggggtgctcggcgttct	Protospacer
  . ************.** *******  .

197. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to NC_012223 (Enterobacteria phage SSL2009a, complete genome) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cttgagcgaggtcgggaaggtccgcgtatt	Protospacer
.    ************ **** ***** .

198. spacer 12.1|1856607|30|NZ_CP017146|CRISPRCasFinder matches to FJ750948 (Enterobacteria phage SSL-2009a, complete genome) position: , mismatch: 9, identity: 0.7

tggccgcgaggtcgggatggtcggcgtagc	CRISPR spacer
cttgagcgaggtcgggaaggtccgcgtatt	Protospacer
.    ************ **** ***** .

199. spacer 7.1|866103|32|NZ_CP017146|CRISPRCasFinder matches to NZ_CP014169 (Sphingomonas panacis strain DCY99 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.688

gcgccagcggtcgctgaccgtcgacgagcact	CRISPR spacer
gcgccagcggccgctgagcgtcggccgaattg	Protospacer
**********.****** *****.* ..  . 

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	797018 : 804399	7	Listeria_phage(16.67%)	tRNA	NA
DBSCAN-SWA_2	1857011 : 1932211	58	Bacillus_virus(16.67%)	integrase,transposase,protease,tRNA	attL 1921613:1921648|attR 1933130:1933165

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NZ_CP017146|797018:804399|DBSCAN-SWA
CGTGCGCCTTCTGTCGGTCATCGCGGCAATCGCGATCGCTACGACCGCCGGCATCTCCGGCAACGCATCCGAGCCCGCCTTCGCGATCGACTACCCCACGTGGGCTGATGTCGAGAACGCCCGCAACAACGAGGCCGCCAAGCAGGCCGAGGTCGCTCGTATTGAGGCAGTGCTCCAGCAGCTCGCCACTCAGGTCGAAGAGACCAAGGCCGCCGAGAAGGCCCGCGGTGAGGACTACCAGGAGGCCCAGCAGGCATTCGACGAGGCGAAGTACAAGGCGGACCAGCTTCAGCTGCAGGCCGACGAGGCCCAGCTGACGGCCGGGGAGTCCAAGCTGCGAGCGGGCCAGCTCGCGGCACGCCTCGCCCGCTCGGGAGGCGGCGACGTCTCCGCCTCGCTGTTCTTTGACGGCGCGTCCGCCGCAGACCTGCTCTCCCAGCTCGGCATGGCAAGCAAGATCACCGACCAGTCGGCCGGCATCTACCAGAAGGCCATCGAAGACCAGAACACGGCGCAGTCGCTCACCGACCAGGCGAACGTCGCCAAGGACGCCCTGCAGGACCTCGCGGATGCCGCCGAAGCCGCCCTCCAGGCGGCTACCGAGGCCGCAGATGCCGCAGCCGCCGCCCTCGCCGAGCAGCAGGAGAACGAGGCGGTGCTGCGCGCTCAGCTCTCGGTGCTCGAGGAGAACCGCGCGGCTACCGAAGCCGACTACCAAGCCGGCGTTCGCGCCCGCGAAGCAGAGGCGAAGCGAGTGGAAGCGGCACGTCAGGCTGCTGTGGCCGCCGCACGGGCAGCCGCAGCGGCGGAAGCAGCGGCCGCGGCCGCAGCTTCGGCAGGCGCAGGCGCAGCAGCAGCCCCCGCAGCCGCCGGCGGATCGCCGTCGCCGTCGGGCTCGTGGGTGCGTCCGTCCTCCGGCTACGTCAGCAGCTCCTACGGATTCCGGGTCAACCCGTACTCCGGTGTGTATGCATTCCACGCCGGCACCGACGTCGGCGCCGGCTGCGGCTACCCTATCTACGCCGCCTCGTCAGGGACGGTCACCTACTCCGGCTGGAGCGGCGGCTACGGCAACTACGTGTCGATCAACCACGGCGGCGGCTTGTCAACCGCGTATGCCCACATTGCCAACGGCGGGCTGCTCGTCTCCCGCGGACAGTCTGTCGGTGCGGGCCAGCTCATCGCCCTCGTCGGCAGCACCGGCGGATCGACCGGATGCCACCTCCACTACGAGGTGCGTCGCGGCGGCGCCACTGTCGACCCGGTGCAGTTCATGAGGGCGCAGGGCGTTTCGTTCTAGGACGGATGCTGGTCAGCTGGTTGCTGGCAGCGGCGTCGCACTTGGCCGTCTCCCGGTGTCTGCGCCCGTTTGTGACGTTTGCGCCCGCTCGAGCGGGCGCAGTTGTCACAAAGGGGCGCCCACGCCGAGGCGGATGCTACAAACGGGCGCAGAAGCCGCAGCGAAGAGCGGCTGCCGACGCGGATACCGACGTCCGCGCGCCCTCCACAGAGGCGCCGAGAGGCTCGCCGAGTGAGGCGCCCCGTGACGGCGCCTAGTGTGTGCCCTCGACCGCGAGCTTCTCGATTCCCGCGACGATGATCGCGTCGGCCTCGGCCGCATCGCCCCAGCCCTCGGTCTTGACCCACTTGCCGGGCTCGAGGTCCTTGTAGTGCTCGAAGAAGTGCTCGATCTCCTTGCGGGTGTATTCCGGGATGTCGTTCAGGTCCTGGATGTGCGACCAGCGCGGGTCGGTCGCCGGCACCGCGATGACCTTGGCGTCGGATCCACCGTCGTCGGTCATGTTGAATACGGCAACGGGGCGCACCTTCACTCCCACGCCCGGGAACAGCGGGTAGTCGAGCAGCACGAGCACGTCGACCGGGTCGCCGTCGAGTCCGAGGGTGTTCTCGAAGAAGCCGTAGTCGGTCGGGTACACGAATCCGGTGAACAGCACGCGGTCGAGGTACACGCGACCGGTGATGTGGTCGACCTCGTACTTGTTACGGCTCCCTTTGGGAATTTCGATAACGGCGTCGTAGCTAGACATGGCGGGACCTTTCGTGGAACGGCGAAGTGGATGCTGGTGCGGGAAGTGGATGCGCGGAACCGACCGGCGGCGCGCTGCAATAACGTTACTGGATGACCATGCGCCGCCGTCTGACCCCCGCGATCGCCGATGTGCGCCGCGCGGTGCGGACGGCGCTCACGGGCGCGTCACCCACAGCGGACGAGCCCACAGCGGACGAGCCCGCCTCCGACGAGCCCACCGCGGTGCACCGTCCCCTCGTCCTCGTCGCCCTCAGCGGTGGGCCCGACTCGCTCGCCCTTGCCGCGGCGACCGCGTTTGAGGCGCCCCGGCTCGGGCTGCGGGCCGGCGCCGTGATCGTCGACCACCGGCTGCAGCCCGGATCCGCGGATGCCGCAGCGGAGGCCGCCCGGGCCGCCGCCGCCCTGGGGCTCGACCCGGTTCTCGTGCGCGAGGTCACTGTCGATGGCGCCGGGGGGCCGGAGGCCGCCGCGCGCGAGGCCCGCTACGCCGCACTCGATGCCGCGCTCGCCGACACCGGAGCCACCCGCCTCCTGCTCGGCCACACCCTCGACGACCAGGCCGAGACCGTTCTTCTCGGCCTGGCGCGCGGCAGCGGCGCCTCGAGCCTGTGGGGCATGGCCCGCGAATCCGGCACCTACCTGCGCCCGCTGCTGGGCATCCGCCGCTCGATCACGGAGCAGGCCTGCGCGGATGCCGCGCTCGAGCCCTGGCACGACCCGCAGAACACCAATTCCCTGTACACCCGGGTGCGCGTGCGCCAGCGGGTGCTCCCCACCCTCGAGCACGAACTCGGGCCGGGCGTCGCGGAGGCCCTCGCGCGCACAGCCGAGCAGCTGCGGGAGGATGCCGAGGCGCTCGACCACTTCGCATCCGAGATCATCGAAGAACTCGCCGAAAGCGCCGAAGCCGGCATCTCGTTGCCCGTCGCCGCGCTCGCGGCGAATCCGCCCGCACTCCGCCAGCGCCTCATCCGCCTGGCTGTTCGGGCCGAATTCCACGTCTCGCTCGGCCGCGCGCACACGCTCGAGGTCGCGCGCCTCGTTACCGATTGGAACGGGCAGGGTCCACTGGACCTGCCCGGCGTTAGGGTGGAACGGCGACACGGCCTGATCGTCTTCAGCGCTGCCGCCATCCACCCAAACGGCTGACACGACCCACCGGAGCACCATGCAACTCACCGACATTGCCGACGACCTCGACTCGACGCTCTACACCGAGAAGCAGATCCACGACAAGATCGCCGAGCTCGCCGCGCGCATCGACGCGGACTACGCGGGGGAGACCCTCCTGCTCGTCGGCGTGCTCAAGGGCGCCGTGATGGTGATGGCCGACCTCGCACGGGCCCTCACCCTGCCGATCGAGATGGACTGGATGGCGGTGTCGTCGTACGGCTCCGGCACGCAGTCGTCGGGCGTCGTGCGGATTCTCAAAGACCTCGACACCGACCTCACCGGGCGCAAAGTGCTCATCGTCGAGGACATCATCGACTCTGGGCTCACCCTCTCCTGGCTGCGCGCCAACCTCGAGAGCCGCGGCGCGGCATCCGTCGAGATCTGCGCCCTGCTGCGCAAGCCCAAGGCGGCCAAGGTCGACGTCGACGTGCGCTACGCGGGCTTCGAGATCGCCAACGAGTTCGTGATCGGCTACGGGCTCGACTATGGGGAGAAGTACCGCAACCTCCGCGGAATCGGCGTGCTCGCGCCCCACGTCTACGGCGACTGACGCCCAGACCCGGTCATTACGCCGCCAGCAAACACGCGGGAGGCATCCAGCCCGGCGGCGGTAACCTGACAGACACCACTACCACCTTGAAGAAAGGCGCCGGGCCGACACCCGGGACACTATGGATTTCAAGAAGTTCCTGCGCGGCCCGCTCGTCTACATCCTGCTGGCGGTCGTCGTCGTCTCGATCGGGTTCAGCCTGCTCACCGGGTCCGGCTTCAAGGAGATCACGACCCAGGAGGGCCTCGAGCTCCTCAAGGACAACAAGGTCGCGACCGCAACCGTGATCGACGGCGAGCAGCGGGTCGACCTCGTGCTCAAGAACTCTGGCGACGACGGCGAGAACGTTCAGTTCAAGTACGCGACCCCCCGCGGCGAAGAGGTCATCACCGCCATCAACGGGTCGAACGTGACGACGTTCGACGACGAGGTCACCACCACCAACTTCTTCACCTCGCTGCTCGGGCTGATCATCCCGTTCCTCATCATCGGCCTCATCTTCTGGTTCCTGCTCAGCCGCATGCAGGGCGGCGGCAACAAGGTTATGCAGTTCGGCAAGTCGAAGGCCAAGCTCGTCTCCAAGGAGACCCCGCAGGTCACCTTCGACGACGTCGCCGGGGCCGACGAGGCCATCGAGGAGCTCCGCGAGATCAAGGACTTCCTCAAGGAGCCAGCGAAGTTCCAGGCCGTCGGTGCGCGCATCCCCAAGGGAGTGCTGCTCTACGGCCCTCCCGGGACAGGCAAGACCCTGCTCGCCCGCGCCGTCGCCGGCGAGGCGAACGTGCCGTTCTACTCGATCTCGGGATCGGACTTCGTGGAGATGTTCGTCGGCGTCGGAGCCAGCCGCGTGCGGGACCTGTTCACCCAGGCCAAGGAGAACTCACCCGCGATCATCTTCGTCGACGAGATCGACGCCGTCGGTCGGCACCGCGGCTCCGGCATGGGTGGCGGCCACGACGAGCGCGAGCAGACCCTCAACCAGCTGCTCGTCGAGATGGACGGATTCGACGTCAAGACCAACGTGATCCTCATCGCGGCGACCAACCGCCCCGACATCCTCGACCCCGCCCTGCTGCGCCCCGGACGCTTCGACCGCCAGATCGGCGTCGATGCCCCCGACATGATCGGCCGCAAGAAGATCCTCGAGGTGCACGCCGCGGGCAAGCCGATGGCCGCCGGCGTCGACCTCGAGGTACTCGCCAGGAAGACCCCCGGATTCACGGGCGCCGACCTCGCCAGCGTGCTCAACGAGGCCGCGCTGCTGACGGCCCGCTCGAACGCCCAGCTCATCGACAACCGTGCCCTGGATGAGGCCGTCGACCGCGTCATGGCCGGCCCGCAGCGCCGCACGCGCGTCATGCGCGACCAGGAGAAGCTCATCACCGCGTACCACGAGGGCGGGCACGCGCTCGTGGCGACCGCGATGAACAACACCGACCCGGTCACCAAGATCACGATCCTGCCCCGCGGCCGCGCCCTCGGCTACACGATGGTCATGCCCGTCGAGGACCGCTACTCGGTGAGCCGCAATGAGCTGCTCGACCAGCTCGCCTACGCGATGGGCGGCCGCGTCGCCGAGGAGATCGTCTTCCACGACCCGACCACGGGCGCGTCGAACGACATCGAGAAGGCCACCGCGACCGCGCGCAAGATGGTCACCGAGTTCGGCATGAGCGCGAGCATCGGCTCGGTCAAGCTCGGTTCGAACCACAACGAGATGTTCGGTCGCGAGATGAGCGGAACGCGCGACTACTCCGAGCGGCTCTCCGAGCAGGTTGATGCCGAGGTGCGCACCCTCATCGAGAACGCGCACGACGAGGCGTGGAGCGTGCTCAATGACAACCGTGACATCCTCGACGCGCTCGCCCAGGAGCTGCTCGAGCGGGAGACGCTCGACCAGACCCAGCTGAAGGAGATCTTCGCGGCGGTCAAGAAGCTCCCGCCGCGCCCGCAGTGGCTCTCGAGCACGAAGCGGCCAGTGTCGGACCGTCCGCCGATCCTGATGCCCGAGAAAGCACCGATCGACGCAGGCGCGACCGAGGGCGCTATCGATTCGGCGCCCCAACCGGCGGCGAAGCGAGCCCCGCGCCGTCCGGCGCCCGGCGTCGCCCCGGCCTAGCCCCGTGGCCGGCATCGACACCGATCGCATCGCCAACGCTGTCGCCGAGATCCTCGCCGCGATCGGCGAGGATCCGACGCGCCCCGGGCTCGTCGATACCCCGCGCCGGGTCGCGCTGGCGCACGCCGAGTACTTCTCCGGCCTCGGCCGTGATCCGCTCGAGCACCTCGTCGACACGCTCCCGGTGGACTCCGCGACGGGCGACCTGGTACTGCTGCGCGACATCGAGGTGCGCTCGATGTGCGAGCACCACCTCCTCCCGTTCACCGGTGTGGCCCATATCGCCTACGCTCCGCGCGAGAGAATCATCGGACTCGGCCGTCTGCCCCTCGTGGTCGATACGCTGGCCTCGCGCCCCCAGCTCCAGGAGCGATTGACCGAGGAGATTGCGGATGCTGTTCAAGCGGGCCTTGATCCCCGTGGGGTGCTCGTCGTCGTCGACGCGGCCCACCAGTGTGTTTCGGCGCGCGGTGTGCGCCAAACGCGGAGTTCGACGGTGACGATGGCAGCCCGCGGCACGCTCGCGGATCCCACCGGGCGGGCCGAAATCATTACGATGATCGGAGCGCCCCGTGTCTAACCATCCCGCCACACCCGTCCAGTCCGCCACACCCGTCCAGTCCGCCACACCTGTTGTCGCGGCACCCACGCGGTCCCGGCGCGCGAAGCCAGCCGGATCTCTCCCGACCGGCCCGGTGCGACCGCTCATCCTGGGCATCCTCAACGTCACCCCCGACTCGTTCAGCGACGGCGGGGCTCACGACTCCGTTGCCGCAGCCGTGGAGTATGCAGTCCACATGCGAGAGTGCGGCGCCGACCTCATCGACGTCGGCGGCGAGTCGACCAGGCCCGGGTCCGAACGTCTCCCGGTCGAGGAGGAGCAGCGCCGGGTGCTGCCCGTGCTCGACGAGCTCGCCAAGCGGCGCATACCGGTCAGCATCGACACGATGAACGCGAGCACCGCCGCGGCGGCCGCCGAGCGGGGCGCCGCGATCATCAACGACGTGTCCGGCGGCACCGCCGACGCCGACATGGCCAGGGTCGCGGCCGAGACGGGGCTCATGTTCATCGCGATGCACTCGCGCGGGCCGAGCGGGACGCGCACCACCTACCGGGACGTCGTCGACGAGGTGCGCCTCGAACTCGAGTACCGCGTCGCCGCGCTGATCATGCAGGGGGTGCACCCCGGGCAGATCATCGTCGACCCCGGAATCGGCTTCGCGAAGGACTCCGCGCAGAGCTGGGAGCTGCTCGGCGGACTCCGCGAGCTGCGCGCCCTCGGCCATCCCCTTCTCGTCGGCGCCTCCCGCAAGCGATTCCTCGGCGAGCTGCTGCCCACGGGGGCCAAGCCCCGCAAGCGGGACGCGGCGACCGCCGTGATCAGTGCGCTGTCGGCCGAGGCGGGCGCCTGGGGCGTTCGCGTGCACGACGTGCCCGCGACCAAGGCGGCCCTCGACGTGTGGAGCGCCATGAACGGAGCAGTGCGGTGA

Protein sequences of DBSCAN-SWA_1

>NZ_CP017146|797018:804399|800911_802909_+|WP_161885251.1|DBSCAN-SWA
MDFKKFLRGPLVYILLAVVVVSIGFSLLTGSGFKEITTQEGLELLKDNKVATATVIDGEQRVDLVLKNSGDDGENVQFKYATPRGEEVITAINGSNVTTFDDEVTTTNFFTSLLGLIIPFLIIGLIFWFLLSRMQGGGNKVMQFGKSKAKLVSKETPQVTFDDVAGADEAIEELREIKDFLKEPAKFQAVGARIPKGVLLYGPPGTGKTLLARAVAGEANVPFYSISGSDFVEMFVGVGASRVRDLFTQAKENSPAIIFVDEIDAVGRHRGSGMGGGHDEREQTLNQLLVEMDGFDVKTNVILIAATNRPDILDPALLRPGRFDRQIGVDAPDMIGRKKILEVHAAGKPMAAGVDLEVLARKTPGFTGADLASVLNEAALLTARSNAQLIDNRALDEAVDRVMAGPQRRTRVMRDQEKLITAYHEGGHALVATAMNNTDPVTKITILPRGRALGYTMVMPVEDRYSVSRNELLDQLAYAMGGRVAEEIVFHDPTTGASNDIEKATATARKMVTEFGMSASIGSVKLGSNHNEMFGREMSGTRDYSERLSEQVDAEVRTLIENAHDEAWSVLNDNRDILDALAQELLERETLDQTQLKEIFAAVKKLPPRPQWLSSTKRPVSDRPPILMPEKAPIDAGATEGAIDSAPQPAAKRAPRRPAPGVAPA
>NZ_CP017146|797018:804399|798570_799065_-|WP_161885248.1|DBSCAN-SWA
MSSYDAVIEIPKGSRNKYEVDHITGRVYLDRVLFTGFVYPTDYGFFENTLGLDGDPVDVLVLLDYPLFPGVGVKVRPVAVFNMTDDGGSDAKVIAVPATDPRWSHIQDLNDIPEYTRKEIEHFFEHYKDLEPGKWVKTEGWGDAAEADAIIVAGIEKLAVEGTH
>NZ_CP017146|797018:804399|797018_798317_+|WP_161885247.1|DBSCAN-SWA
MRLLSVIAAIAIATTAGISGNASEPAFAIDYPTWADVENARNNEAAKQAEVARIEAVLQQLATQVEETKAAEKARGEDYQEAQQAFDEAKYKADQLQLQADEAQLTAGESKLRAGQLAARLARSGGGDVSASLFFDGASAADLLSQLGMASKITDQSAGIYQKAIEDQNTAQSLTDQANVAKDALQDLADAAEAALQAATEAADAAAAALAEQQENEAVLRAQLSVLEENRAATEADYQAGVRAREAEAKRVEAARQAAVAAARAAAAAEAAAAAAASAGAGAAAAPAAAGGSPSPSGSWVRPSSGYVSSSYGFRVNPYSGVYAFHAGTDVGAGCGYPIYAASSGTVTYSGWSGGYGNYVSINHGGGLSTAYAHIANGGLLVSRGQSVGAGQLIALVGSTGGSTGCHLHYEVRRGGATVDPVQFMRAQGVSF
>NZ_CP017146|797018:804399|800235_800790_+|WP_161885250.1|DBSCAN-SWA
MQLTDIADDLDSTLYTEKQIHDKIAELAARIDADYAGETLLLVGVLKGAVMVMADLARALTLPIEMDWMAVSSYGSGTQSSGVVRILKDLDTDLTGRKVLIVEDIIDSGLTLSWLRANLESRGAASVEICALLRKPKAAKVDVDVRYAGFEIANEFVIGYGLDYGEKYRNLRGIGVLAPHVYGD
>NZ_CP017146|797018:804399|803619_804399_+|WP_161887330.1|DBSCAN-SWA
MGILNVTPDSFSDGGAHDSVAAAVEYAVHMRECGADLIDVGGESTRPGSERLPVEEEQRRVLPVLDELAKRRIPVSIDTMNASTAAAAAERGAAIINDVSGGTADADMARVAAETGLMFIAMHSRGPSGTRTTYRDVVDEVRLELEYRVAALIMQGVHPGQIIVDPGIGFAKDSAQSWELLGGLRELRALGHPLLVGASRKRFLGELLPTGAKPRKRDAATAVISALSAEAGAWGVRVHDVPATKAALDVWSAMNGAVR
>NZ_CP017146|797018:804399|799157_800216_+|WP_161885249.1|tRNA|DBSCAN-SWA
MTMRRRLTPAIADVRRAVRTALTGASPTADEPTADEPASDEPTAVHRPLVLVALSGGPDSLALAAATAFEAPRLGLRAGAVIVDHRLQPGSADAAAEAARAAAALGLDPVLVREVTVDGAGGPEAAAREARYAALDAALADTGATRLLLGHTLDDQAETVLLGLARGSGASSLWGMARESGTYLRPLLGIRRSITEQACADAALEPWHDPQNTNSLYTRVRVRQRVLPTLEHELGPGVAEALARTAEQLREDAEALDHFASEIIEELAESAEAGISLPVAALAANPPALRQRLIRLAVRAEFHVSLGRAHTLEVARLVTDWNGQGPLDLPGVRVERRHGLIVFSAAAIHPNG
>NZ_CP017146|797018:804399|802913_803489_+|WP_161885252.1|DBSCAN-SWA
MAGIDTDRIANAVAEILAAIGEDPTRPGLVDTPRRVALAHAEYFSGLGRDPLEHLVDTLPVDSATGDLVLLRDIEVRSMCEHHLLPFTGVAHIAYAPRERIIGLGRLPLVVDTLASRPQLQERLTEEIADAVQAGLDPRGVLVVVDAAHQCVSARGVRQTRSSTVTMAARGTLADPTGRAEIITMIGAPRV

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_161885247.1|797018_798317_+	peptidoglycan DD-metalloendopeptidase family protein	A8ATH6	Listeria_phage	3.4e-14	46.5
WP_161885248.1|798570_799065_-	inorganic diphosphatase	A0A2H4J8U1	uncultured_Caudovirales_phage	7.2e-34	51.4
WP_161885249.1|799157_800216_+|tRNA	tRNA lysidine(34) synthetase TilS	NA	NA	NA	NA
WP_161885250.1|800235_800790_+	hypoxanthine phosphoribosyltransferase	A0A1V0SEQ1	Hokovirus	2.6e-08	32.4
WP_161885251.1|800911_802909_+	ATP-dependent metallopeptidase FtsH/Yme1/Tma family protein	G8DDJ2	Micromonas_pusilla_virus	1.7e-105	44.6
WP_161885252.1|802913_803489_+	GTP cyclohydrolase I FolE	E7DN69	Pneumococcus_phage	1.5e-35	45.1
WP_161887330.1|803619_804399_+	dihydropteroate synthase	S4VNV0	Pandoravirus	3.3e-25	34.0

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NZ_CP017146|1857011:1932211|DBSCAN-SWA
TCTAGACTGTTTGCGTGGTTTGGTCGTTGATCGGGAGGGCCTCTTTCTGGGGTTCGTTGATCCAGACCTCGGTGCGGATCTGTGGCGGGCGGGGTCGTCGGGTGAAGCGTTCGGGGTGCTCGTTGAAGGCCCGGTTCAGGGTGACCGAGCGTTGCTGGTCGATGTCCTGGTAGGTGCCGAAATGCACGGATGCTGGGGTGTGCCAGCCGATCCCGGAGTGATGGTGGATGTGGTTGTAGTCGGTGAAGAATCCGTCGCAGAATTGCTTCGCCTCGGCCAGCGAGTAGAAGTGGTGCGGGAAGTCGGGAACGTATTTCAGGGTCTTGAATTGCGCCTCGGAGTACGGGTTGTCGTTGGACACCCTCGGGCGCGAGTGCGTGCGGGTGATCCCGAGATCGGCCAGCAGTGCGGAGACGGGTTTCGAGGTCATCGAGGTGCCCCGGTCTGCGTGGACGGTGTGCGGGGCGGTGCCGTTGCGGCCGATCGCGTCGTCGATGAAGTCGCGGGCGACGACCGAGTCCTCGGCAGCGCAGACGACATGGCTGGGCGAGTACCTCGAGTAGATATCGATCAGGGCGTAGAGGTGATACCAGACGCCCTTGCGCGGGCCGCGGAGCTTGGTGATGTCCCACGACCACACCTGCGACGGGCCCAAAGCGACCAGCTCGGGCTTGACCTTCGCCGGATGCGTCGCCAGACGCCGCCGTTCCCGCGTCTGCCCGGCAGCCCTGGCGATGCGATACATCGACGACATCGAGCAGTGGTACCGGTCCTCGTCCAACTCCCGTGCCCAGATCTGACAGATCGACAGGTCCTGGTAGGCGGGAGAGTTGATGACCGCGAGGACTTGTCCGCGTTCCGTTTCGGACAGGGTCGATGGCGGCTTGGCCCGTGCTGCCTGCGGGATCGGATCGATCTTCCGGACCGGCGGGGAGATCCGCCGGTAGTGGGTCGCCCGCGACCGGCCGGTCAACGCGCACGCGGCCACGACCGTGACCGCCAATCCGATCAGCGCAGTGAACGCGTCATCGAGGACCGTTCCCGCAGTCACTTGTCCTGCCCCGTCCCGGGCTGGCTCGAGGGGCTGCTGTCCGAGAGCAGCTCCAAGAGCCTGTGCGCTTTTCCCATCACGTCCAACGCTGCCTCGGTCTGCGCCAGCCGGCGATGCAGACGAGCGTTCTCGGCCTCCAACTTCACCGCCCGGGCAGCCGCCGAGGACTCCTTCGATCGCGGGGCGCGATCCCGCCGATACGTGGTCCCAGCCGCTTCCGCGTCTCGGGCTTTCGCCCACTCCGCTACCAGGGTCTGATAGATCCCCTCGCGTCGAAGGACCGCGGACTTCGACCCGCGGGGGGCCGCCTCATACTCTGCCAGCACGCGAGCGCGGTATTCGGCCGGGTAAGTCCTCCGGACCGGCTTCTGAGCCGGGTCAATATGCGGGGCCGGTGGCCCTGATTCTTCCAACATGATTACGTCCGTTCCCCGCCCTCTCCCAAGACACCCCGCATAACCCGGGATGTCTCACACCAGCCTGACAGAGAGGGGCTCGCGTTCCTTCTGGCTATGGCGGTGATGGCGGTGATGGTGGGGGTTCTGCTGGGGAGCAGGATGAGGGTTTGGGTGGGGTCGATGTTTCGGGGTGGTTGGAGCCAGTAGTTGTTGTTGGTGTTGGTGATTTCCCAGTGGTTGTCGTGGAGGAGGAGGTGGTGTCTGCGGCAGAGGAGGATTCCGTTGTCGATGTTGGTGGGTCCGTTGTCTCTGTCCCAGTGTTTGATGTGGTGGGCTTCGCACCAGGAGGGGGGTCGGTCGCAGGAGGGGAACATGCAGCCTCCGTCGCGGGTGGCGAGGGCGATGCGTTGGCGGGCGGTGAAGTGGCGCCTTGTGTGGCCGACGTTGAGGCATTGGCCGTCGTCGTCGAATAGGACGGGGATGTGTCCGGTGTCGCAGAGGTTGCGCTGGATGGTCTCGATCGAGATCGGGTCGAGGGTTCCCTCGATCCATCCCTGGTCGGCGCTGATCCCGGGCAGCCGCAGTCGCGGTGGCGGTGGTGGTGGCAGGGGCGGTTGCGCCGGGTGGGGCGGCGCGAGGGGCTGCGCGGATTGAGACGGTGGTGGGAGGACCGGAAGGACCGGAAGGACCGGGAGGGTGGGGCCGCTCGGGGTGCCGGTGCCGGTGCCGGTGCCGGTGCTCGCGTCGGTGCTTGTGCCAGCGGTGGGTGTGGTGTTGGTGGTGAGGTCTTTTTTGGTGATGATGACCCGGACGGCGGGGCGGCGGGAGCCGAACATGGTGCCGGGGTCGGCGTCGGTGGCGATGCGGATCATGCCGATCAGGGCGTCGGCGAGGATCTGCTCGTCGGTGCGGGGGTCCTCGACCAGTTTCTGGGCTTTGGCTTTCTCTTCCGGATCGATGAATCGGGGTCCGCCGCGTCGCGGGGAGAGGATCGTGGACAGGGCCGAGTCGAGCAGGGCGCCGTCTTCGGGGTGCAGGTGCCAGATGCCGTGGTGCATGCCGTCAGCGGTGCGCCATTTGCGCACCGCGCGCAGGTCGTACTGCTCCTTCTCCCGCCGGCGGATGCCGTCGCTGTCGAGCTCGTCCCGCAACCGCCGGGCGAGGCGTTGCACCTCGTCCGCACCCAGCACCCGACCGGCGCCGGCACTACCGGGGTTACCGGGGTTGCTGGGGTTGCTGGGGTTGCTGGGGTTGATGGCGGTGATGAGGTGTTCCGCGGCGGCGGTGAGCTGCTCGGCGGTGACGGCGTCATCGATCCCTCCCAACCCGCGCCGGATTGCTTCGGCTCCATCGAGGGAGAGGAGCCCGGCGGTGACCGCCCGCGCGATTGGCGCCTGCCATACCGGCATCCCGACCGGGAAACGCGGCTCGGCAGGGTCGGTGGCTGGCCCCGGGCTGGCCGGGGAGCCCGGATCGGACACCGGCGCACCAGCGGTCGGCGCACCAGCGGTCGGCGCACCAGCGGTCGGCGCACCAGCGGTGGGCGTGCCGCCGGTGGCGGTGGCGGTGGGATCGGCGGCGGCGAGGGCTTCGGCGGCTTCGGTCTCGGCGAGCAGGGTGCCGATCTGGACCAGTTTCGCGGCCTCGGCCCTGGTGCTGCCGGAGATCGATTGGATCAACGCCTCCGCGCTGACGAACCCGGCACTGATCGCCATCCCGGCATGGCCCAGGGCCCGGTCGGAGTGCTTCGCGATCGCCGCCGCGATCCACGCCGCATAGGTGTCCACCGCACGACGCAGCGCGGTGACCGAGCGTTGCGCGGCGAACAGGGACGCATCATCCAGGGCCGTGAACTCCCCCGCGCACGCCCCAAGGCCAGCGACGGTGTCAGCCGTGTCGCGGAGGGTGTTCGGGAGCTGTTCCATGCCACAATTCTCCCACTTCGAACACACTTTCGAAAGGGGAAAGGCCTGATGGGGACAAGAATCTTTCCACAAGGGCTGTGCAGGAGAAGACCCTGTGCAGGAGAGAAGACCCTGTGCAGGAGAGACGACCCTGCGCAGGAAAGAAGACACAGCGCAGGAGAAGACCCGGCGCAGCACCGGGCCCGCGTGCACTGCGTTGGAGTCCAACGAGCGCAGCTCACGACGGCCCCTGACGACCGCCCCTGACCACGGCCCCGAAGGGGCTACCGCAGCCCGCTCACTCTGAGCACGACGCCCCGCACATTTTGGATCCGCTGCTCGTACCTCGCCGCGAGGCCGATGAGAATGATGCCGCCGACGGCGAGCCACAACCACCAGGGGAAGAACTCGTAGACCGCCCTGATTTGCGGAGCGAACGTCGCGATCACATGTACAAGAACGACGGCGGCGCTGATCAGGAATGGTGCCTGCAGTCGCCGAACCGCGCCGATGACGAGGATCGCGACTCCCGCGACGCCGATGCCGACGAGACGCCAGACGGGATTGTCGTCGATGGTCGCGACGAGGGACGGTACAAGCAGCGCCGCAACGCCCGGGCCGAGCCAGGGCCAGCTTCGGGCATCCGGGTCCGAGATCAGCCGCACAGCACCGGTCGCAATGAGAGCGGCGGCGAGCGGGATCGTGCCGATCTCGAGGGGGTCGAGGGATCCCGCGACGACGCCGACGATCACCGCGATGGCAGCATAGGCGAGCGCGAGCCACGCGACGAGCTGCGTGAAAGGCACCCGATCAATCAGGAAAGCGATCACATGGATGGCGCAGAAGACGAGTGTCGCCCCGAGCGCCCGAAGAAGGCCGGTTGGGCCGTCATCGATTGCCATCGTTTCGATCGTGATCATGGCAGTGAACGCGACGATGGCGAGCGCCTGGCTGGCGACGAGTCGCTGACGTGCGAATGCGTCGCCGGCGGCACCGGAGAGCTGATCCCGGCTCAGGCCGAAGCCGGCCGCGACCAGCACGAGTAACGCGAAGCCGAGCCAGGCTTCGAGTTCCCCGCTGGGCGTGCTGCGCAGGCCACTGTCGACCAGGATGTTCGCCGCGCGTGCGACGGCCGTGACGATGACTCCGATCCCTCCGGCAAGGGCCGCGGCGTCGAGATGGGGACGGATGCTGGCGCGCCCGACGACCATGCTGCCGAGCAGCACCAGGGCGGCCGAGACGCCGCCGACAATGATCGCGCGGGTCGGCGGGCCGTCCGCGGCGACCACCGCGATCGGCACGATCGAGACCAGCAGCGCGGCGAGAACCAGGACGGGTGCGGCGAGGGCGCCGGACGCCGGAACAGAGCCGGACGCCGGAACAGCGCCGGACGCCGGACCAGAGCCGGACGCCGGAACAGCGCCGGACGCCGGAACAGCGCCGGACGCCGGACCAGAGCCGGACGCCGGAACAGCGCCGGACGCCGGACCAGAGCCGGACGCCGGAACAGCGCCGGACGCCGGAACAGCGCCGGACGCCGGACCAGAGCCGGACGCCGGAACAGCGCCCCCGTTCTCAAACGTCACGCGGCGATCGGCTCGCCAGAGCAGGAGCGCGATGATGAGCAATGCCCCCGACAGCGGAAGCACCCAGGGCTCGACCACGGTCACCCCGCGGTCGCCGAGCGCGAGCCACAGGCCGATCGTCGAAAGGGCGAGCGCCACCCAGGCGAGGTAGCGGCGCGGTGACTTCGAGGCAAACACCCCGTCGCGGCTCGTGCCGAGCAGGAGGGTCGCGATCGCGGCAATGACGAGTACCAGCCAGGTCGAGTCGTCCTGGCGCGCGAGCAAGCCCAGCGCGACCGGTGGCACCCCGACCAGCAGCACGCCGAGATCGCGGACCTCGCGCGGGATCCGCGTCTGCCGCATCAGCGCGACGGCTAGCGATCCGGCGCTGACCAGCAGCGCGGCGGTGACGGGCGCGACGGCGAGGACGAGCTCGGGCGCGTCGATCGCGAGCGCGATCGAGAGCAGCACAATGAGCGTGGCCGGCCCGATCGCGACGGATGCCGTGGACCGCTCGACAGGGACGGCGGATGTGGACGGCAGGGCTGTCCAGAGCAGGAGCACGGCGAGCAGGATCGCACTGAGCGCGAGGATCGAGGGAATCGGGGCGAGAAGCGACGGCGCGGATGCGGGACCGTACTGCAGCCAGGCCGCGGAACCCCCTGCGGCAACCAGTGAGATCCAGAAGAGCGTGCGCCGGTCCAGTGCGCTAAGCATCCTCTCGAGCGGCAGGGCACCGAGTCCCAGCGCAACGACTGCGGTGAATCCGACCAGCCGCACCGAGTCGTCTGTGGCGACGACGTCTGTCGCGACGAGGCCAGTGGAGATGCCAATCTGCCGTGCGGCCGCCGCGGCCGCAACAAGAGCCAGAACGAGTGCGATGCCGAGCAGGCCCGCGCGATTGCCTGCGCCGCGCGTGAGCGCACGGGCCAGCAGCGCCAAGCCGATCGTCGCAGCGGTAGCGGGTGCCCATGTCGCCTCGCTGGCCCAGCCGAGCACCCAGCCGGCCGTCGTCGCGACGGCGAGCAGAAGGAGAAGCGCGGGGGTGACGGCCGACCGGCCGATCGGGGCGTCAGGGGCCGCGCGGGCGAGTACCAGGAGCGCGGCGAGCGAGGCCACCCCGAGAACCAGCCAGCCCATCGAGACGAGCACCACGCTTCCGAGCAGAGGGACCGCGACGATAAGCACGGCGGCGACCATGAACGCGAGCAGGCCGATACGACGCCGGAGCAGACCGCTGACAGCCCAGCCGATCGCCCCGAGAACGGTCACAGCTGCGAGGGTGAGGATCGCGTCGCGAAGCGCCGCCGTCGGGTCCACGATGGTGTCGGTGGGGGACAGCGTCCACGGTTCCGCGAGCGCGGCCGCGAGAGCGAGCAGGGTCGCGGTGCCGCCCGTGACGAGAGGCTGAACCACGGCGATCACCGCGACGAGGACTGCTCCGCCTCCGGCCACAGCGAAACTCCGGCGCAGGAAGGGATCGGTCACGCGGCGCGCCCCTGCCTCGAGGATCAGGGCGACCGCGACGGCGACGACCGCCGGGATGAGGACCGCGGTGAGGCCCGAATCGCGAACCACCGCGACGGTGCCGGTCACGGCGAATGCGACGCCGAGCGCGCCCGCGAACACGGCGCCGAACGTGACGAGACGTGGCTCGGGCAGCGACCGGAGGACGACGAGGTGAAGCGCGGCGGTCAGGCCGAGGAAGGCGAAGGTGGTGGTGGATGCTGCAGGGCCCACGAACGCCCAGGCATCCGCTCCACCCTCCGATCCGAGTACGGGATCGAGCCAGATCATGGCGATGGCGGCAAGAGCCGCTCCGGCCAGAGCAGCGAGCGAGGTGACGAGCACGATCCAGCGCTCGGTGCGCGCGGGGCCCTGGATGCTCGTGGCCGTCGCCGTAGCCGTGGCCGTGGCGGGGCGTCCGGCGAGCCGATGCAGGGTGCCCGCCATGGCGACGGCCACGAAACTGATCCCGAGCCTGACCGACTCGGGCGCCGACGACGCCGCCGAATAGGCAAGAAGGCCGACGCCGGGCGCGAAGGTCGCGAATCCGGCGATGCTCGGCGCGCGCAGCGTCGACGCGCGGTTCCAGACCACGAAGGCGGTGCCAGAGGCGACGAGGGTGAGTCCCCAGAACGCGTCGCCGTCGACGGTGCCTGCGCCGACGAGGTTATTGGCGCGGATGGCGAAGGCGTCGAGATAGACGAGAACTATCGCGAAGACTGCGATTCCCTCGGCGGTGGTGCGCAGTCCCCGACGTCGCAGCAGTTCCGCCCCCGCGATCGCCGCGAGCGTGATCGTGCCGATGATGACCGAGCGCCAACCGAGCCCGAAGTTGATGAAGGCGTAGATGAGGAAGAAGATCGCGCCGACGGACAGCGCCGATACTCCGACGATGAGCAGGGCGAGCTGCACGCTCGAGACGCGGCGGCGGTCCGGGCCAACAGGAGCGGCATCAGCAGGAGGAGCAGGAGGAGTGGGACGAGCAGGAGGCGCGAGAGCAGCGGGCGCGATAGTACGCGCGTCCTGCGGACCCGCGACAGCAATGGGCGCCCCAGCAGTAACTGTCAGAGTCGACCCGGAAGCAGCCGCGAGTGCCATGGCTGCGATGGCCGCGGCACGCGCATCCGTCTCGAAACGCATGCGGCCGATGATGTCGACGCGGTGGGAGAGCATCGAGGAGGCCTCGCGCGAAGCCGAGAACAGCTCCCCGGCGGAGGGATGGTTGAGGTCCAGTCCGCACTCGCCGCAGACCGTGCCCGGAAGCCGAGAGAAGCAGGCCGGGCACAAGCCGCGATCGGTGAGAGCGCCGAGACCGCTCGGCCAGACCACCAACCCCGCATGGGGACGAAAGTCGACGGGTCCGTCGCCGGTCATGAGCACTCCTCGAGGTAGAGGCCTCAGGCTAGCGCTCCGCCGAGTTCCCCGGGGGAAAGGAGCGGTGGCGGGGGAGACTCCGCGTCACGACACAGGCAGTGCTGCCAGGTCAGGGGGAGCTGACGAGCTCCACCTTGTAGGCCGACGAGACCTGGATTTCCGCACGCGGTTCTTCGATTTGGTTGGTCCACATCATGCCGTTCCACCAGCGCAGCTGGGGAAGGCCGAGGGGGTCGCGGTACCAGCCGGAGGGCGCGAGGGGGGAATTTTCACTAGCGGGCATGGTGGGTCTCCATGTTTGAGTGTCCGACCGCGGCGGACGATTCGGGTGCGGTCGTGGTGCATGCCGAACCGTGGCGGCCATTCAGGGGGCGGTTAAACTGAGCATAGTCCTCCTTATGGGGGACACCGCGCCCCCCTAAACGGGGGTCGAGAAACGGGGGTCGAGAAACGGGGGTCGAGAAACGGGGGTCGAGAAACGAGGGTCGAGCTGTCTCAGCCGAGAGCCTCGGGACGCTTCCAATCCGCGCCGTGCACGTGCTGGTCGAGGAAGGCGAAGACAGTCTCGTACCAGACGACGGCGTGCTGGGGCCCCAGCACCCAGTGGTTCTCGTTCGGAAAATAGAGGAACTTGTGCCGCGTCGTGCCGTCCGGCTCGGCGTGGTGCTCGGCCAGCTCCGACCACAGCCGCAGGCTCTCCCCGACCGGAACCCGGTAGTCGCGGTCGCCGTGGATGACAAGCATCGGCGTCGAGATGTCGCGCACGCTGTGGTGCGGCGAACTGTCGAGCATGCCCTGCGGGGAAAAAATGCTCTGCCAGTACTGCGAATTGTCGGTCGTCCCGTTGAACTGGTCGAGCGCCCACAGGCTCGCGTGGCTGACGATCGCGGTGAACCGATCCGTGTGCCCGGCGATCCAGTTCGCCATGTAGCCGCCGAAAGATCCGCCCATTGCGGCGGTCTTCGCGGCGTCGATGTCGGGGCGTGCTTCGGTGGCATCCGTGATCGCGAGGAGGTCGGTGTAGGGCTTCGTGCCCCAGGCATCCCAGCCGCGCGCGATGAAGTCCAGGCCGTACCCCGTCGACAGCGCGGGGTCGGGAAGCAGCACAGCGTACCCCCGGGCGACCGCGAGCAGCGGGCTCCAGCGCCAGCTCCAGGCGTTCCAGCTGTTCAGCGGTCCGCCGTGGATCCAGAGCAGCAGGGGGGCCGGATGCTGGGCGTCGGAGCCGTCGGGCAGCAGCAGCCACGCGCGCAACGGCGACCCGTCCTCCGCCACGGTCTCGACCTCGGTGATCGAACCGGGTGCCTCGGGGAGCGTCGCGGGCGTCGCGGGCGTCGCGAGTGGAACGACGTCGCCTGCCCGGGTGATCCGCACCGGATGAGACGGTGCCATCCACGAGGAGCGGAGTGCCACGAGGTCACCGGTTGTCGGATCGACGGCAACGTGGGTGTAGCTGAAGTCGTCGCTGGTGAGCTGCGCAGCGGCGCTACCGTCGAGCGGAATGCGGAATATTGGGCCGCGGCCACCGTGGTCGGCCGTCACGATGAGGGATTCGTCTCCCAGGTCGAAGATCGTGCTCGAGGGCCAGCGGTCCCAGTCCGCCCCGAGTCGGCGCGGCTCGCTCCCATCGATGCCGGCAACCCAGATCTCCTGGTCGGCCGGTCCCTCGGGGGTGCTGAATGCGCTGCGCACGAACGCGACACGAGATCCGTCGCGGCTGACCACGGGGGACTGGAAATGCACGCGGTCCTCGTCGAAGAGTGTCGTGCGCTGCCCGGACTCGACGTCGATCGCCACCAGCACGTGCCGGCCGGAGCGCTGCTCCCGCACGCGGAGCGAGGCGATCATCGTGCGGCCATCGGGAGTCAGGGCCTGCCCTGCGGTGTCGCCAGCGCGCCCGGGCGCCGGGGTGAGGTCGTTCGGCCTCGGCAGCTCGGCCGGGTACGCGGCGGCTGCGGCTGCGGCTGCGGCCGGGTCGGGGTTCGGGTCGGCGGTTACCGGTGCGGAGATCGACTCGGCGAGATTCGACAGGTCCAGCGAGAGCAGGTGCGGTTCGGCCGGGCCGAGATCGTGGTCCCAGTAGCGCACCGGGTAGCTCTCGTGCAGGATCGCCGAGACCTTCTTATCGCTGCGATTCTTGCGCGCGGCGGCATCCGCCTCGAGGCCGTCGGCGCTGGGGAGCAGGTCCGCGGTGATCACGATCGTGTCTGACGACGTCGCCGTCGCGGCGATGCCAGAGACACCTCCCGCCAGACGGGTCACCGCGCGCGCCTCGCCGCCGCTGGCGGGCAGCAACCAGAGCTGCGCGGCCTCCGTGTCCTTCTCTGCCGCGGCATCCGGCCGGCCGGAGACGAACATCACGTCGCCCGACCCGGTGAACGCGACGCCGGATTCGCCCTTCGCGGAGCGGGTGAGCCGCGTCGGTGCGCCGGTGCCGTCGGCGGGCACCGCCCAGAGCGCCCTCTCGTAGGAGGTGGAGTCCCGCGCGAGCGTCGCGACGGTGAGCACCACCCGGTGCCCGTCGGGCGAGAGCGCGAGGCCCTCGATCCGGGGGAGCGCGATGAAGTCGTCGAGGGAGGAGAACGGCAGGTGAACCTGGTGAACCTGAGCTGACATGTGCTCCACGCTAGCCCGAAGCCGGAGCGAACTCGCGCTCACGGCGCTCCATCACGCGGTCTACTCGGCGCTCTGCCGCCTGCGGTGCGCGACCATGTTCATCCGGTTGCCGCAGCGCACGGTGCAGTAACGCCTCGAGCCGTTGCGGGAGAGGTCGGCAAACAGGCCCTCGCAGTCGTCTGCCTCGCAGATCCGGAGGCGGTCCGTGCCGTCCGAGCGGATGACATCGACGAGGGCGAGGGCGCCCTCGGCGCGGATGCGCTCGGCGAGCGGGGCATCCGCCCGGGTGGCGTGCAGGTGCCAGTCGAATCCGTCGTGGCGCGCGAGCTGGGGGAGGGCGCGGGTGTCGCGCAGCATGGCGTTGACCTCGCTGGCCATCGAGTCGCGGTCGAGCGCCCAGATGCGGCGGAGCTCGAGGCGCGCCGCACGTACATCGCCCAGTTCGGCGTCGTCCCGATCGACACGCCCGGTGTAGCCATGGATAGCGAGGAGGGCCTGCAACTGCAGGGTCGACGACAGCTCATCAGTGCCGCTTCTCGTCGACGAGGGCACCGTGTTCGCGAGGGCGACGTTGAACGCGAGAAGGTCCTCGGTGTCAGGGGCAAAATGCAAATTGACTCCTTATTCCTGAACACCCTAATGTCAGTGTCAACAGCCCCACTAGATCATGACGGAAGGATGCGCGTGAACCGTTCGCCCTTGTCGGCCGGACTCATGTTCGCGCTCGTCGCAGCTGCATCGTTCGGGGTCTCCGGCGCGCTGATCAAGCCCCTCCTCGAGGGTGGCTGGAGCCCCGCCGCAGCGGTCACGGTTCGCGCCCTCACGGGTGGACTGATCCTCGCGCCATTCGCCGTGATTGCACTGCGCGGACGCTGGGGCTCCGTCTGGCTGGGGCGCTGGCGCATTCTCGGAATGGCCACCGTCGGTGTCGCGGGCACCCAGCTGTTCTACTTCGCCGCCGTGCAGCGCATCCCTGTCGGCACGGCCATCCTGATCGAGTACATGGCCCCGCTGCTGCTTGTCGCTGTCGCCTGGGCGATGACCAGGCGACGGCCAGCGGTCGTCGTTCTCGCAGGCTCGGTTGCGGCCTTCGCGGGGCTGCTGCTCATCGTGTCTCCGTCCGGATCCGGCGCACTCGACCCGCTCGGGATCGCCTCCGCCGTCACGGCGATGGTCTGCTGTGCCGGCTACTTCGTGATCGCGGCGAGGCCGAGCGCCGGACTGCCGCCGGTCGCCCTGGCATCCGCGGGGCTCCTGATCGCACCCGTGCTTCTTGCTCTCGCCGGTCTTCTTGGGATGGTGCCGTTCACCGCCTCCGTCGACGAGGTGACGCTGCTCGGCCGGGCGACCCCATGGTGGGTGCCGATGCTGGTCGTCGGCGTCGTCTCCACAGCAGTTGCTTATGCGACGAGCATCACCGCGGGCGGGATGCTCGGCTCACGGCTCGCCTCGTTCGTCGGCCTCCTCGAGGTCGCGGCGGCGGGACTCTGGGCGTGGATGCTGCTGGGGGAGAGCCTGACGATGCTGCAGTTGTTCGGGGGTGGGCTGATCCTCGTGGGCATCGGGTTCGTGCACTCGGACCGGTCGGTCCCGGTCGCTCCGGTCGGGGAGAAGACCCCGGCCTTTGGGCCCTCCCGCTGACGAACTGCCGGGCGTACCCTGTCGCCATGAATGAGACGACGGAAAGCTCACGCAAACGCCCCGAGACGCACGGATCGAGTGAGGCCGGGCGCTACCTGCGATTCATCGACTGGCTGAACCGCTCTCTTGAGGGTCCGCTCGGACCACCGCCGAGCGGACCGTTCGATGAGGTCGTGCAGCAGGTCGGCGCCGCCACCTGCCCGGTGTGTAACCGTCCGATGTCGGAGCACCGCATTGACCACACCGTGTCGAACGCCGTGCTGCACTGCCCCGTCGGTCACGAGCGGCCTGCCGAACACCAGGAGCCGCTGAACGAACTGGGAATGCCCAAGCGCCCACACGACTGATCGAATGATGTGATGGAGGGGATGACGAGAATCGAACTCGCATCATCAGTTTGGAAGACTGAGGCTTTACCACTAAGCTACATCCCCGCACGACCGGCCCGATTACCTTGGGCCGGATAGCACTCTGCAACTCTAATGCATGCCGCGGGGTGAGGGTGGCACCTCGCGACGCGGCGCTCGGCTAGACTTGCCACGGCCAAATTTCGGATGCCTCATGATCCGATCCCCCTGGCCGCACGATGATGTCCGGGGCGTAGCTCAGCTTGGTAGAGCGCCCGCTTTGGGAGCGGGAGGCCGCAGGTTCGAATCCTGTCGCCCCGACAAGAATCCCTCATACCCAGTACGCCGAATACAGGAGAGCCACACGTGAAGACCACGGTCGAAAAGCTGAGCCCCACGCGGGTGAAGCTCACCATCGCAGTTACCCCGGACGAGCTGAAGCCCAGCGTCGACCACGCCTATACGCACCTCGCGGAGTCAATCAACATTCCCGGGTTCCGCAAGGGCAAGGTTCCGCCGCCCATCATCGACCAGCGCGTCGGTCGTGGTGAGGTGCTGAACCACGCGGTCAGCGACGGCCTCGACAAGTTCTACCGCCTTGCCGTCACCGAGGAGAAGATTCGCCCCCTCGGCCGCCCAGAGGCCGACGTCACGGGCCTGCCGGAGCTCAAGGACTTCTCGGGCGACCTCGTGATCGTCGTCGAGGTCGACGTTCGCCCGGAGTTCACGCTCCCGTCGATCGACGGCCTCGAGCTCACGGTCGACACCGCGACCGTCGAGCCCGACGAGGTCGAGACCGAGCTGCAGAATCTGCTCGCTCGCTTCGGCACGCTTGTCACCGTCGAGCGCCCGGCCAAGACGGGCGACTTCGCCCAGATCGACCTCGTCGCGTCGATCGACGGCACCGAGGTCGACACCGCCAACGCCATCTCGTATGAGGTCGGCTCCGGAGACCTCATCGACGGCATCGACGAGGCCCTCGACGCCCTCAGTGCCGGCGAGACCACGACCTTCGAGTCCAAGCTGCTCGGTGGCGACAACGAGGGACAGACCGCGCAGATCACGGTCAACCTCCTCGCCGTCAAGGAGCGCGAACTCCCCGCGGCCGACGACGATTTCGCACAGATCGCCAGCCAGTTCGACACGATCGACGAGCTCAAGGCAGACATCGAGCAGCAGGTCATCAAGTCGAAGGTCTTCGGTCAGGGCGCGCAGGCGCGTGACCAGGTCGTCGACAAACTGCTCGAGTCCGTCGAGATCCCCGTTCCGGAGAAGCTCGTCGAGGACGAGGTGCACCGCCACCTCGAGAACGAGAACCGCCTCGAAGACGCCGAGCACCGTGCCGAGGTCGCCGAGTCGAGCGAGAAGACGTTCCGCACTCAGATCCTCCTCGACTCGATCGCCGAGCAGGAGAAGGTCAAGGTCAGCCAGAACGAGCTCACCCAGTACCTCGTGCAGGGCGCCGCACAGTACAACATGGAGCCGGGCGAGTTCATCAAGGTGCTCGACCAGAACGGCCAGATCCCCGGCATGATCGGCGAGGTCGCGCGTGCCAAGGCGCTCGCGATCGTGCTCAGCCGCGCGAACGTCGTCGACGGAAATGGCGACGTCGTCGACATCTCGTCCTTCACCGCGACGGCGCTGAGCGATGCAGGCGACGACAGCGACGCGAGTGACTTCGTCGAGGCGGCATCCACAGCGGATGACGACCACGAGGGTCACGACCACAGCTGAACTGCATGAACTGACGACGAAGGCCCGGCACAGCAGTGCCGGGCCTTCGTTGTTAAAACCCCTTCGTCGTTAAGACCGCAGGCCGGATTACGCCCGGTCATCGATCCAGTCAGGTTCACCACGGTGCGCCGGGGTGCGAGCGTGGACGCAATGGACATGGCGCGGTTTCGGGCGCCGGAGACGACGCTCGGCGGCGGGTTCTTGCTGTCGAGCGTCGAGAGCGCGAGTCCGACGACATCGGCCGGTTCCTCGAAGTCGCCGACACGGGCGCCAGCGCCTGCCACATCGAAGAACTCGGTGCGCGTAGCTCCGGGGGAGAGGGCGAGCACCAAAAGAGCGGTGTCCTTGTTCTCGTACCAGAGCGCTTCGGTGAAGCTCAACACGAACGCCTTGCTCGCTGCGTAGACCGCCATCAGGGGGACCGGTTGGTATGCGGCGGTGCTCGCGAGAGTCACAAGGGCACCGCGTCCCTCCTGCAATTGGGCGTAGAACGCGTGGGTGAGTTCCACAAGCGCGGTCACGTTGAGGCTGACCTCCTCGTGGATGCGCCCGGCGGCCTCGTTCTCGAACCGACTGCGCGTGCCGAAGCCTGCGTTGTTGATGAGGGTCGAGATGCGGATGCCCCGCTCGCCCAGGTCGGCGTGGAGGTTCGCGGCCGCGCCCGGTGCAGCGAGGTCCGCGGTGATCGTCGTCGCCGTGATGCCGTGCGACGCGGTGAGTTCATTTGCGAGGGAGTCGAGACGGTCGAGACGGCGGGCGACGAGAACGAGATTGGCGCCTCGGGCCGCGAGCTGGCGTGCGAACTCCGTGCCGAGCCCCGAGCTCGCGCCGGTGATGAGGGCGGTTGTGCCCCGGTAGTCCAATGCCACGATGGTGCCTTTCGGATTATGGTTTCTGCGATCGTCTCACTGCGAATCGGCTCGGTGACCCGTGCCCTAGCGTTGTGGCATGACCTCGCGACCCGACAAGCACGACCCGCTGACCCTCCGGCTGCTAACCCAAGCCGTGCACGCCGGCAACGCCATCGATCCGGGAACCGGAGCGGTACGCACGCCCCTCGTGCTCGCGAACTCCTACGCCCTGCCCGACGATCCGTCCGAGATCAGCTGGTCGGGCACCGACATCCCCCTTTACACCCGCAACAGCGGCGTCAACCAGCTCGCGCTGCAGCAGAAACTCGCCGTTCTCGACAACGGGGAGGATGCCGTCGCCCTCGCGAGTGGAGTCGCCGCGCTGCATGCCGTGTTCTTCACCTTCCTGAAGTCCGGCGACCACGTCGTTGTCGCCGATGTCGTCTATGAGGCGACCCACCGCCTGTTCACGGAGCTGCTGCCGGAGAAATACGGCATCGAGGCGACCCTCGTCGACACAACCGACCTCGCGGCCGTGCGCGCCGCCATCCGACCGACCACACGCCTCGTGCATGTGGAGACCCCAGCCAATCCGACAACCCGGATCACTGACATCCACGAGCTCGCGCTTATCGCCCACAAGGCCGGGGCGCTGCTGAGCGTGGACTCGACCTTCGCCTCGCCGCTGCTGCTGCGGCCCCTCGACCAGGGCGCCGACCTCGTCGTGCACTCGCTCACCAAATACATCAATGGCCACGGAGACGCGATGGGCGGCGCTGTGATCGGGTCGCGGGAGCTGATCCAGCAGATCAAGAGCGACGCCATGATTGATGTCGGGGGAGTGATCAGCCCCTTCAACGCCTGGCTCATCATGCGCGGCTCGATCACCCTGCCGTTGCGGATCCGCCAGCACTGCGTGAACGCGCGGGCCGTCGCCGATGTGCTCGATGCCGATGACCGCGTCGCCTTCGTCGCCTACCCGGGCCTCGCCTCGCATCCGCAGCACGAGCTCGCGCGCCGCACGATGCCGAACGGGTTCGGTGGGATGCTCGCGTTCGCCGTGGTCGGGGACTCCGCGACGCAGGACCGGTTCGTCTCGAACCTGCGCGTGATCACCTCGGCCGTCTCGCTCGGCCACGACGAGTCCCTCATCGTGCACGTGGGCAGCACCGCCCCGCGGGCCGCGCACTGGCCCGAGGAGTTTCGCACCAACGGGCATCTGCGCTTCTCGGTCGGGATCGAAGACCCGGCCGATCTGATCGCCGACCTGCGGGCCGCCCTCGACGCCACCTTCGCCCCGGACTGACCTCCCGCTATCTGCCCACGGCGAACACGCCCGATTGCGTCGGTGCTTGCCGATAGATTCGAAACCAAGCGAAAACTGAAATGGAGCGCAACAATGGCCCAACCGGCATTGGTCAACAGCATTTTCGACCAACTCCTCAAGGACCGCATCATCTGGCTCGGGTCAGAGGTGCGCGACGACAACGCCAATGAGATCTGCGCGAAGATCCTGCTGCTTGCGGCTGAGGACTCCGAGCGAGACATCTTCCTTTACATCAACTCTCCCGGAGGCTCGATCACCGCTGGCATGGCGATCTACGACACGATGAAGTTCGTGCCGAACGACATCGTCACCGTGGGCATCGGACTCGCGGCGTCGATGGGCCAGTTCCTGCTCTCGTCCGGCACCAAGGGCAAGCGGTACATCACGCCCAACGCGCGGGTTCTGCTCCACCAGCCGTCCGGCGGATTCGGCGGCACCTCTGCCGACATCCAGACCCAGGCCAAGGTCATCCTCGATATGAAGCAGCGCATGGCGGAGCTCACCGCAGAGCAGGTCGGCAAGTCGGTGGAGCAGATCCTAGTCGACAACGACCGCGACAACTGGTTCACAGCCCAGGAGGCGCTCGCCTACGGGTTCGTCGACCACCTGCGCGAGTACGCATCAGAGGTCATCGGCGGCGGCGGCACCGACGAGACCGTCACCGACGCGGCGGTCTCGACCGATTCGGACAACGACCACACCTCCCGCACGACCGACACCCCGAAGAACTAAGGCACACACCATGGACATCTCTTCCTACGGCGGAAGCGCCGGCCCGATGGCCGAATCCCGCTATATCCTCCCGACCTTCGAGGAGCGCACGGCGTACGGCTACAAGCGCCAGGACCCCTACGCGAAGCTCTTCGAAGACCGCATCGTCTTTCTCGGGGTCCAGGTCGACGACGCGTCGGCCGATGACGTCATGGCCCAGCTGCTCGTCCTCGAGAGCCAGGACCCCGACCGCGACATCGTGATGTACATCAACTCACCCGGTGGCTCGTTCACGGCGATGACGGCGATCTACGACACGATGCAGTACATCCGTCCGCAGATCCAGACGGTCTGCCTCGGCCAGGCGGCTTCTGCCGCCGCTGTGCTGCTCGCCGCGGGAACGCCCGGCAAGCGTCTCGCCCTGCCGAACGCCCGCATCCTGATCCACCAGCCCTCAACGGGCGACGCGGGCCGCGGCCAGGCGTCGGACATCGAGATTCAGGCGCAGGAGATCCTCCGCATGCGCACCTGGCTCGAGGCGACTCTCTCGTTCCACTCGAACCGCAGCCCCGAGCAGGTCAACAAGGATATCGACCGGGACAAGATCCTCGGTGCGGATGCCGCGCTCGAATACGGACTCATCGACCAGGTGCTGACCTCGCGCAAGAACGTTCAGATCCCCGCGGCGCTGTCCAAGTAGCCCGCGCGCAATAAGACCCGCACGCAGAAAGACCCGCAGGCATCGCCTGCGGGTCTTTTGTGTCTCTGCTGAGCTGAGCTGCGCGGTGCGGCTCAGGCGTTGCGGCGCCGGCGCACAGCGAACACCGTCCCGCCGATCGCGGCCGCGGCGACCGCACCGATACCGGCGATCAGCAGCGAGTTCGGCACGGTCGATGACGTCTGCTCGGGGTCGGCGGATGGCGATTCGCTGGCATCGGCATCGGCATCGGCATCGGCATCGGCATCGGCGCCAGCCGCGTCATCGGAGTCGGTCCCGGACGCCTGTCCCTCTGCCGGCTCCTCCACCGGCGTCGGCTCGACCCCGCACTCGGGAGGCGTCGCCGAGCCGGCCGAGATCTCGGCGTCATCGGCGGGATCCCACTCGAAGGTGAACTGGCCATCGATGGGGTGGCTGTCGATCGAGGCCGCGCGCCAGGCGAGGGTGTACTCGCCGGCCGGCCCCAGTGCGGCGTCGGCGCTCATCGTCGGGCCGTCGACCGAGACGCATCCGTCGCCGTAGTACAGGCCGTCCTCGCCGACGACTCGGAGCAGGAATGCGCTCACGCTGTCGCCGGTGTCGAGCATGTCCTCGTTCGTGGTGATCGAGAACTCCGGCGGGAGGGTGGTCAGGATCGAACCGGCCTCCGGAGTGGAGGCGACCAGAGAATTGTGGGCCATCGCCGGGCCGGCGACCGCGAAGATGGAGCCGAGCAGGACCGCGCATCCGAGAAGTGCCGGCAGTGCCGTATTGGGTCGCCGAAAGCCACGGCTCGGTGGGGAGTACGTCATGAATCTAGGCTACGTGAGCAGTCTGATCGGTCGAACCACGAGCGAACAGCGCCGCGGCGCGGCATCCCAATCGTGCAACGTGCATTCCTGTGTCGGTGACACGGGTTAGGCTCGATGCGTAGCACTAGTGATGGCAACCCGCAATGGCGCGGTGCTGAATCAGGAGGAGGCGAGGCAATGGCTCGAATTGGTGAGAGCGCGGATCTGCTCAAGTGTTCCTTCTGCGGAAAGAGCCAGAAACAGGTCCAGCAGCTCATAGCAGGACCGGGCGTGTACATCTGCGACGAGTGCGTCGAATTGTGCAACGAGATCATCGAAGAGCGTCTGGCCGAGGCTGGCGAAGAGGTGTCGAGCGAGTTCGACCTGCCCAAGCCCAAGGAGATCTTCAACTTCCTCGAGGAATACGTCATCGGGCAGGAGCCGGCCAAGCGGGCCCTCTCGGTCGCCGTCTACAACCACTACAAGCGCATCCGCTCACGCAACACGCTCACCTCCGCAGACGCCGTGATCGACGATGTCGAGATCGCAAAGAGCAACATCCTGCTGATCGGCCCGACCGGTTGCGGCAAGACCTACCTCGCCCAGACCCTCGCGAAGCGGCTCAACGTTCCATTCGCCGTCGCCGATGCGACCGCCCTCACCGAGGCCGGCTACGTGGGTGAAGACGTCGAGAACATCCTGCTCAAGCTCATCCAGGCGGCGGACTACGACGTCAAGCGCGCCGAGACCGGCATCATCTACATCGACGAAATCGACAAGATCGCCCGCAAGGCCGAGAACCCGTCGATCACCCGCGACGTCTCCGGCGAGGGCGTGCAGCAGGCACTCCTCAAGATTCTCGAGGGCACCGTCGCATCCGTTCCGCCGCAGGGCGGGCGCAAGCATCCGCACCAGGAGTTCATCCAGGTCGACACGACCAACGTGCTGTTCATCGTCGCCGGCGCGTTCGCGGGCCTCGAGGAGATCATCTCGTCACGCGCTGGCAAGAAGGGGATCGGCTTCGGCGCCCCGCTGCACAGCAAGGGCGACGACGTGAACCTGTTCGGCGAGGTGCTGCCGGAAGACCTGCACAAGTTCGGCCTGATCCCCGAGTTCATCGGCCGCCTCCCGGTCGTCACGACCGTGACCCAGCTCGACCAGGTCGCTCTCATGGCGATCCTCACCGAGCCGCGGAACGCGCTCGTGCGCCAGTACCAGCGCATGTTCGAGATCGACGGCGTCGAGCTCGAATTCGAGCACGACGCGCTCGAGGCGATCGCCGACCTGGCGGTGTTGCGCAAGACAGGCGCCCGCGGGCTCCGCGCGATCATGGAGGAGGTGCTCGGGCCGATCATGTTCGAGGTGCCTTCCTCGTCCGATGTCGCACGCGTGATCGTCACCAAGAGCGCCGTCGTTGAGAACGGTGCCCCGACGATCATCCTGCGCGAGGTGCGCACCGAAAAATCGGCCTAGCCGCACCAGGTTCCCGGTCCGCCCATTATCCAGCCCATCTCCGCCGGCCTCATCGGCGCGATCACCGGATTCGCCAGCTCGTTCGCGATCGTCATCGCGGGCCTGCGCGCGGTGGGGGCGACCGAGGAGCAGGCGGCGTCCGGGCTGCTCATCCTCTGCCTGACCCAGGGGCTCGTGGCGATCGTGCTGTCGTGGCGGTTTCGGATGCCGCTGTCGTTCGCCTGGTCCACCCCCGGAGCCGCGCTGCTCGTGACCGCCGAGGCGACGACGGGGGACTTCTCGGCCGCGGTCGGCGCGTTCATCGTGTGTGGAGCGCTGATCGCCGTGACGGGCGCCTGGCCTGCTCTCGGGCGCGCCATCACCCGCATCCCTCGGCCGATCGCGAGCGCGATGCTCGCCGGCATCCTGCTCCCCATCTGCATTGCGCCCGTCACGGCCTCGGTCGCCGAGCCGCTGCTCGCCCTCCCGATCGTGATCGTCTGGCTGGTTCTGTCACGCCTCGCGCCGCGCTGGGCTGTGCCGTCCGCGATGATCGTAACGGCGATTGTGGTGGCGCTCTCGGTGGGCACCGGATGGCTTGGCGCCGGGGTCGTCGCGCCGCAGCTGAGTTTCGTGCCGCCGAGCTTCGACCTGCTCGTGATCGTGAGCCTGGGGCTGCCGCTGTTCGTCGTGACCATGGCCGGCCAGAACGTACCGGGGTTCGCCGTGCTCTCGACCCTCGGGTTCCCACCGCCGCGTCCCGCCCCGATCCTCATCGGCTCCGGGCTCGTCTCGATGGGTGGGGCGCTGTTCGGCGGGCACGTCATCAACCTCGCTGCACTCACCGCGGCCATCATGGCCGGTCCCGACGCGCACCCCGAACACGCCAAGCGCTGGATCGCCGCCGTCGCGGGAGGCGCGTTCTACCTCGTCCTGGGCCTCGGCGCCGGCCTCGCCACCGCCCTCGTCACCGCCTCCCCGCCGATCCTCATCACGGCGGTCGCGGGCCTCGCCCTCATCGGAGCCTTCATCTCGTCGGTCACCGCAGCGCTCGAGACGCCGGAGCACCGGCCGGTCGCCGCAATAACCTTCCTGGTCGTTGCCTCGGGAATCGTCATCGGAGGCATCGGCTCGGCCTTCTGGGGACTCGTCGTCGGCGGGCTCGCGATGCTCTGGTTGGGCTTCAGACGCCGCCCCGCGCCAGCGCGCACGGCACCGTAAGAGTGCACGGACGATTGCCCCGCCCATCGACATTGCGCGGCGATATTGCCCATCGACATTTCGCGGCGAGGAATGCCAGAGCGTCCTCGCCGGTTCTCGCTGGGGATGACTTCCTTCAGCGCGATCCCGCTCTCCGTTCTCGACCTCGCCACGGTCCGCGCCGGAATGACCAACGCCGAGGCCCTTGCCCAGACGATCACGACGGCGAAGGCGGCCGACGAGCTGGGCTATCGGCGCTTCTGGGTGGCCGAGCACCACGGCATGGCCGCCGTCGCGAGCTCCGCGCCCGCGGTGCTCATCGGGGCAATCGCCGCGGCGACCACACGAATCCGGGTGGGATCGGGCGGCGTGATGCTGCCCAACCACTCCTCGCTCGTGATTGCCGAGCAGTTCGGAACCCTCGTTGCCCTGCACGGCGACCGCATCGATCTGGGGCTCGGACGCGCGCCGGGCACTGACGGGCTCACCGCACGGATGCTGCGCCGCAACGTGCAGAACGAGACCGCCGACGATTTCCCGCAGCAGGTTGTCGAACTGCTCGCGCTCTTCGGCATCGTCCCGCCGCTCGAGAACGGCGTCGGTGCGACTGTCGTCGCGGTGCCAGGCGCTGGCGACGCGCCGCTCATGTGGCTGCTGGGCTCGAGCGGCTTCAGCGCGCAGCTCGCCGGCATCATGGGCCTGCCCTTCGTGTTCGCCCACCACTTCGCCGGCACCGCGGAGACGCCGCGCGCTTTCGAGCTGTACCGCGAGCGGTTCACACCCTCCGCTGTGCTCGAGAAGCCGCTTGCGATGGTCTCGGTGGCGACGGTCGTCGCCGACGATGCGAAGGAGGCTTCCCGGCTCGCACTGCCCCACAACCTCTGGGCGGTGCGGTTGCGACAGGGCGGCCGACCCGGTGCCGTGCCCACCCTCGCCGAGGCGGAGGCACACCCGTGGACCGAGGGCGAGCGCGCGTTCGCCGCGGAACGCAACGCCCAGCAGGCGGTAGGCTCCCGCGAGCACGTGCGGTCGCGGGTGAGTGCCCTCGTCGAGGCGACGGGAGCGAACGAGGTCATCCTCGTGCCGCAGGGCCCCGACCTCGAGTCCCGGCTGCGCACCCTGACGGAACTCGCGGCCTGAGCCACGCTGATTCGCCGAGGGCGTGCCGAACGCCTATCGTTGACCGACATGATTTCGCGACGAGAAGCTGCCCTGCGCCTGGACATTCCTATCGAGATGGCGCAACGTCACGGGCTCGGTACGTGGGTGTCGGAGGAGGAGCTTGCCGCAATCGAGAGCGAGCCGCCAGCCTGGCTCGTGCAGTCGCGCGCGAACCGCACGGGTAAGAAGCCCGTCTGGGTGCGCCTGGAGTGCGACGTGTGCGGATTCGGCGAATCGGTGCGGCCGAAGAAGTGGTGGCCGCAGTTCACGTTCATCAGCTGCGATCACCACTCTATTCACGACCTGCCGGAACCCGCAGGCGGGCACGTCCGCCGTGAGTTCGACGGGATCGGCAGCCGCTTCATCGGCATCCTGGACGATGCTCCCGATGCTCCCGAGGGGCCCGACGCTCCCGACCAGCCAGCCTCCTAGCTCAGGCCGCGCCGCTTCAGCAGTGGCTCGATCACGGCATCCCGGCCCCGGAAGTCGCGGTAGGCCTCGAGCGGGTCTTTCGAGCCGCCGACACCCAGCAGGCGGTCGCGGAACCTGTCGCCGTTCGCACGGGTAAGCCCGCCGTTCTCCGTGAACCAGTCGACAGTGTCGGCGTCGAGCACCTCGCTCCAGATGTACGAGTAGTACGCCGCCGCGTACCCGCCCGAGAAGGTGTGTGCGAAGTAGGTGGACGAGTACCGCGTCGGCACCGCCGGGTTGTCGAGCCCGGCGGCAGCGAGAGCGTCCCGCTCGAATGCGGCGACGTCGGTGACTGTCGCGTCCGGTCCGATGGCGTGCCAGGCCTGGTCGAGCAGCGCCGCGGCGAGGTACTCCGACGTCGCGAACCCCTCGTTGAAGGCGGACGACGCCTGCAGCTTCGCCACCAGCTCCTCCGGCATCCGCTCGCCGGTCTCGTAGTGCACGGCGAAGTTCGCGAGAACCTCCGGCCACAGCATCCACATCTCGTTCACCTGGCTGGGGAACTCGACGAAGTCCCGGTACACGTTCGTGCCGGAGAACATCGGGTAGGTCACGCGTGCGAAAAGCCCGTGCAGCGCGTGGCCGAACTCGTGGAAGAACGTGTTCACGAGGTCGTAGGTCAGCAGGGTCGGGGTTCCGGCGGCGGGCCCCGGCACGTTGAGGTTGTTGACGACGACCGTCGGATGCCCGAGCAGGCGTGATTGGGAGATGAGCGCATTCATCCAGGCACCACCCCGCTTCGAGTCGCGGGTGTAGAGGTCGAGTAGGTAGAGGCCGATCTCCTCGCCGCCCTCGTTGCGTACCTCGAATACGCGCACCTCCGGGTGGTAGCCGACGAGGTCGGCGCGTTCGGTGAAGGTCACCCCGTAGAGCTTCTCGGCGGCGAAGAAGATGCCGTCGTGCAGCACCCGCTCAGCCTCGAAGTACGGGCGCATCGAGGCGGTGTCGACGTCGTACTTCGCCGCGCGCACCTTCTCGCTATAGAAGTCCCAATCCCACGCCTCGATCTGGTGCCCGGCAAGAGCCTCCAGCTCGGCCTGCTCGGCCCTGGCATTTCTGGCCGCGGGCGGAGCGAGCCGGCCGAGCAACTCGGACACCCTCGCGGGGCTCTGCGCGGTCGAGTCGGCGGTGACGTAGGCGGCGTGCGAGGCGAACCCGAGAAGCGCGGCCCGCTCTGCCCGGATGCGGGTGATCTCAAGAACGAGGGCGCGGGTGTCGTGGTCGCCCCCACGGATGCCGCGGGACCGGGAGGCCTCCATGATGCGCTGGCGCACGTCGCGCCTGATGAGCTGGGAGAGATACGGATGCCCAGTCGGCAGCACCAGGGTGATGAGGTACTTGCCGTCAAGCCCGCGCTCGGCCGCTGCGGTGGCTGCAGCCGAGATGTCGTCGCGTGAGAGGCCGTCGAGCTCGGCGACGTCATCGATGACGACGGCGAGATCGTTGCTGTCGGCGAGCAGGTTCTTCTCGAACCTGGTCGTGAGCGTCGACAGCTCGCGGTTGTAGTCGCGCAGGGCCTGCTTCTCCGTCTCGCCCAGGCCGGCGCCGGCGAGGGTCAGCTCGGCGAAGTGGCGGTCGACGAGGTACCGGGTCTCGGGGTCGAGGGGAGCGGTGCCCGCGTCGGTGCCAGCGTGGATGCCAGCGTGGATGGCGGCGACGCGCGCGTAGAGAGCCGGATCGAGCCGGATCGCATCGGAGTGCGCCGCCATCCGCGGTGCGATCTCCTCCTCGAGCGCGGAGACGAAGTCGTCGTTGTCAGCGGAGCTCTTGTTGTAGAAGACGCTCGCGACCCGCTCGAGCAGCTGCCCGCTGCGCTCGAGCGGAAGCAGGGTGTTCTCGACCGTCGGCGCGTCCGGATCGGCGCTGATTGCCGCGACCTCCGCGAGCTGCTCGGTGAAACCCGCGTCGAAGGCGGGCCGGAAATGCTCCGGCGCGATCTCGGCGAACGGAGGGAGGCCGTGGGGGAGCGTGCTCGGGGCGAGGAACGGGTTGGGATGCGACATCCCTCCACCCTAGGGTCGTCGCAGGATTATCGCGTTGCCCCCTCCGACGCGCGCGCGATGACCCTCTCCTTCGCACGACGGGCCGTCTTGCGGTACGCGCGCTCGGTGTCGATCGCGACCTGCTCCCAGGTGAACCGAGCCGCGACCCGCCGCGAACCGGCTACTCCGAGGCTCGCCATCCTGCCGTCGTCGGCGAGTAGGCACGAGAGCGCTGTAGCGATAGCCTCCGCATCCTGCGGCGGCACGTGAACCCCCGTGATTCCGTCGATGACAGTATCGATGAGGCCCCCGACCCCGCTGGCCACGACGGGGATGCCGCACGCCATCGCCTCGAGCGCGACGACCCCCGAGGTCCCATGCCGGGGGGCGCAGATGACGGCGTTGGCCGACCTCAGAATTGCGGGCATGGAGGCGTGCTCAAGCGGGCCACGCAGCTCGACGCGATCCGCGACCCCGAGTTCGCGAGCGAGCGTGCGAAGCATGGCCGTCGCAGGGTCGCTGTCGCCCGCGTGGGCTCCGACGGCGCCACCGACGATGATGAGCTCGGCGTCGACTCCCTCGTCAACGAGCCGTGCGAACGCCTGAATGACGAGATCGAATCTATTGCTGGGCTGGAGTCGGCCGACCGTGACGAGGCGCAATGGCCGTGCCCGCTCCTCGATCTCGCCGCTCGTGCCGAATCGTCGCAGATCCACGCCACACGGCACTACCGAGATCGCACCAGTGGGAATGCCGAGGGACTTGAGCTCGAAGGCCTCGTCCGTGCATGTTCCGATGACGCTGTCCACGTTGCGCGCGACCCAGGGTTCGAGCCACTCGCGGTCAGGCGGACTCGTTTCTGCGGTGGCGCCGTTGCGATGCGAGACCACGCCGAGTCCGTGGAAGGTCTGAGCCACAGGAATGTCCCGCGGCGCACCGATGCGGCGGGCGGCGTCGATAGCCGCTATTCCCGAGGTCCAGAGATGGCTGTGAACGATATCCGGCTTGGAGCGCAGCCAGTCCACACCGAGGCCGTCAGCGAGGTCGGCGAGGTGTGTCAGCAACTCCTCCTCGGGAAGTTGCTCGGTGGGTCCCGCCGTGAGGTGCACGAGTTCGAACCGTGGGGAGATCTCGACGCGATCGGGTAGCCCCGGGACATCCCTCCGCGTGTAGACGGTGACGTGATGCCCGCGCCGGGCGAGCGCGGTGGCGAGCGCGGCGACGTACACGCTCCGTCCACAGGCATCCAGCCCACCGATGGCGGCAAGCGGACTCGCGTCTACCGAGACCATGCTGATTCTCATCGAGTCGTCTCCTCGCCGTGCTGCCGGGTGCTGGATTTCCAGAGAACTGAATATTTTGCTCATCCGGTAGGACTTGAGAAGCCGGCGGCGTGCGGGTATGCCCGTCGGAGACGGTGCGTCGAGAGGCCTAGTCGTCGTCCTCCGGGTCGTCGCGGTGTGCCACGAGTGCGACGTCGCTGACGTCGTCGTAGCGGATGACGGTTCCGTCGTCGAGGTCGACGATGGGCCGCCCCTCGAGCCATGTGAGGGTCCAACGCCACTGGCTTGTGTCAGTGCCGGTCAGCTCCGACTCGATGTCGTTCACGGCCGAGACGACGGCGGCCGGGACGCGGTCGGGGACTTCGCCTCCGATGGGCCAGCGCGTTCCGAGTTGCATGGTGCTCCTATTCTGGTTGGCTTCTGGTTGGCTTCTGGTTGGCTTCTGATTGGCCTAGTCTGCTGGGTCCGAGCGGATTTCCAGGATGGTTTCGAGCTCGACGCCGTCGAAGGCCTCTGTGGCGGCCCGGGTGGGGAACCCGCACTCGTCGACAGGCGCATACACGGGCGTGATTCCTGCCGAGGTACCCACCCACACGATGAGCGGGTCGGCGGCGAGCTGGATGCAGGCGCCCGTGGTGGCGGGCTCGTTCGGTGCGGAGTAGGCCGCGAGGAGGTCATCGCCGCCGGCGATGACGCGACTGGCCCGCTGCACGTCCGGCAACGCGCCGTTGCCGCTATCGCGCCCGTCTTCGCCTTCGCCGCCGCCGTTGGTCGACAGGATGTCGCTCGCCGAGCACACGTAAATATTGAGCACCGCGACGATATCGCCATCGAAGTGCTGGGCGTCGGCTGCGGGGCAGTACTCGAGCAGCTCGCGTGCGGTGACAGGCACGAGCGGCCGGCGCAGCACGGGTTCGGCGGTGCTGGGAGGGTCGCTGCTGGGAGGGTCGCTGCTGGGAGGGTCGCTGCTGGGCGGATCGGTGCTGCTCGACGCCGGATCCGGCTCGCCGCCGGGCGGCGCCGTGGTGGCGCATCCGGCGAGAGCGAGCGCCGACACGAGGGCGACAACGATCCGAAGCCCCGCGCCGACGCGCACGCTCATCAGTCCGTCGCCTCCACGAGCGCCTCGGCGAGCACCACATCGGTGACGGTGATCTCGGGACCCTCGACGAAGTGCAGCTCCGCAATGCGCCCCACGGCCTTGAGGTCTTCGGCAGCCAGGCGCAGCAGCGCGAGTCGCTCGGTCGGTGCATGCACAATGGCCGAGAGCACCTCGGTCTTCTGTGAGGCCTTTGCATCGGTCTTCGCGCGACGGATGCCGATGAGCGCGGTACCGACAACGCCGAGCAGCCCGGTGGGGGAGCGATCGATCGTCGGGGTGGGCCACTGCGCTGCATGCACTGAGCCCTCGTGGGTCCACGACCAGACCTCTTCTGTCGCAAAGGGGATGAACGGTGCGAACAGCCGAAGGAATACGTCCAGGGCGGTCCGGAGCGTGGTGACGGCGGATGCCTGCTCCGCTGGGGTCGCGGCGCCGTACGCGCGCTCCTTCACGAGTTCGAGGTAGTCGTCGCAGAAGGTCCAGAAGAGCTGCTCGGTGCTCTCGAGCGCCTTCGCATGGTCGTAGCCGTCGAGCGCGATCGTCGCGGTCTCGACGACTCGGCCGAGCTCGGCGAGCAAATCGAGGTCGAGGGGGTTGGTCACGGTGGTTTCAACAGCCTCAACCGGCGAGGCCGCGGGGGTAGGGAACGAGTAGACGAACTTCGCGGCGTTGAGCACCTTGATCGCGAGCCTGCGCCCGATCTTGATCTGCTTCGGATTCTGCGGGTCGAATGCAGCATCCGTTCCGAGCCGGCTGGAGGCCGCCCAGTAGCGAACGGCATCAGACCCGTGGGTCTCCAGCATCGCGGCGGGGGTCACCACGTTGCCCTTCGACTTCGACATTTTCTTGCGGTCGGGGTCGACGATGAATCCGGAGATGCCGGCGTTCTTCCACGGCACGACACCATGTTCCAGCTCGGCACGCAGCACCGTCGAGAACAGCCAAGTGCGGATGATGTCCTGCCCCTGGCTGCGCAGCGAGTACGGGAAGACGAGGTCGAAGAGCTCGGGGTCGCTCTCCCAGCCGCCGGCGATCTGCGGGGTGAGCGACGAGGTCGCCCAAGTGTCCATGATGTCGATCTCGCCAGCGAATCCGCCAGGTTCGCCGCGTTGACGCTCGTCGTAGCCGGGAGCCGTATCGGAGGACGGGTCGATGGGCAGTGACGACTCGGACGGCACAATCACGGCTCCCTTGTTGCCGTCCGCGTCGAGTTCGTACCAGACGGGGATCGGCACTCCGAAGAATCGCTGGCGGGAGATGAGCCAGTCGCCGGTGAGGCCGCCGACCCAGTTCTCGTAGCGGACGCGCATGTGCTCGGGGGTGAAGTTGATCTCCTTGCCGCGGGAGATGAGCTTGGTCCGCAGCTCGGGGTCGCGGGCACCGTTGGAGATGTACCACTGCAGCGTCGAGATGATCTCGAGGGGCTTGTCGCCCTTCTCGAAGAACTTCACGGAGTGAATGATCGGCTTGGGGTCGCCCACCAGGTCGCCGCTCTCGCGCAGCAGTTCGACTACACGCTTCTTGGCGCTGAACACGGTCTTACCCGCAAGTTCCGCGAAGGCCTCGATCGCGGCATCCGAGACGATGGCGTCGGGGGCGTCGGCGATGATCCGGCCGTCGGCGCCGATGATGGTGCGGTTAGGCAGGTCGAGCTCGCGCCACCAGACCACGTCGGTGACGTCGCCGAAGGTACAGATCATGGCAATGCCCGATCCCTTGTCCTTCTGGGCGAGGTGGTGGGCGAGAACCGGAACCTCGACACCGAACAGCGGCGTCGTTACGGTGGTGCCGAACAGGTGCTGGTAGCGCTCGTCATCCGGATGCGCAACGAGGGCAACGCAGGCCGGGAGCAGCTCGGGGCGGGTCGTTTCGATGAAGAGCGGCTCGCCGTCGGGCTTGGCGAAGCCGATGCGGTGGTAGGCCGCAGGCTGCTCCTTGTCTTCGAGCTCGGCCTGCGCGACAGCCGTGCGGAACGTGATGTCCCACAGCGTTGGCGCCTCGGCCTGGTAGGCCTCCCCGCGGGCGAGGTTGCGCAGGAATGCACGCTGCGCCACTCGCTGGGCGGGGTCGCCGATCGTGCGGTACGTCTGGGTCCAGTCGACCGAGAGGCCCAGTGCGCGCCAGACGTCCTCGAACTGCTTCTCGTCCTCGACCGTCAGCCGCTCGCAGAGCTCGATGAAGTTGCGGCGCGAGATGGGAAGTTGGTCGGCGGCCTTCGACGAGGCGCCCTCGCCGCCCTTGAGCGGTGGCTCGAAGCCGGCTGCGTAGCCGAGGGTCGGGTCGCAGCGCACGCCGTAATAATTCTGAACCCGGCGCTCGGTGGGAAGCCCGTTGTCGTCCCAGCCCATGGGATAGAAGATGTGCTTGCCGCGCATGCGCTGGTACCGGGCGGCGAGGTCCATGTGTGTGTAGCTGAACACGTGGCCGATGTGCAGGGAGCCGGATGCCGTCGGCGGGGGAGTGTCGATGGAATAGACACCGTCGCGGCCTGCGGCGAGAGCGGCAGCGCGATCAAACATGTAGGTGCCGGAAGACTCCCAGCTGGCCCCCCACTTGCTCTCGAGGCCTTCGAGGGCTGGTTTTTCGGGTATGGCTGCAGACACGTGAAACTCCGGTTCAATATGTGCGGCACCGAGTCAGTGATTCAGTGGTGCCTGAGTGTGGGGGTGTGACGCAATCGTACCGGAGGTCGCGCAGCGACCGTGGATCTGCTGGTTGAGCAGGTCGCGCGGCGACCGTGAGCCTGCTGGTTGAGGAGGTCGCGCGGCGACCGTGAGCCTGCCGGTTGAGGAGGTCGCGGAGTGACCGTGTCGAAGCCGGGCTGGCGGGCGTCTTAGAACGGTGGCGGGTCCTCGTGCTCGGCGTCTGCTCCCCGGGCGTCGGTTCTCTGGTCGTCGGTTCTCTGGGCGCGCGCTGCTTCGTCCGCTGTCTGGTCCGTTCCCTGGGTGTGCTCTGCGGTATGGAGGGCGCGTTGGAGGTTGTCGTGTACTCCGCTGGTGATGATGGTTGCCGGTTCGGTGATGTGTGTCCGCCCCGCGGGGGAGGTCCATTCGAGGGCGCCGGTGCCATCGCGCGTGTGGGCGACTGCCCAGTTGGTTTCGTCTTTGATGGTGTGATGTTTCGGGCATAAATGGGCAAGGTTGTAGTGGGCGGTCGGATGTTGGTGTTGCCATTGCAGGGTGTGGTCGATGTCGCATTGTTCCGCTTGCCTGCTGCAGCCCGGGAAGCGGCAGGTCTCATCGCGTACCCGTAGGAAGTTGCGCAAATCGGTGGGTACCCGGTACCGGTCCCTGCCGACGGAGAGGATTGCTCCGGTCTCGGGGTGGGTGAGGAGGCGGATCATGCCCGGCGCGCCGGCGGCGAGCAGCCTCGCCGTGTTCGGATCGATCGGCCCGTACCCGTCGAGGGACCCGGGCTCCTCGCTCATTCCGAGGAGCACGAGAGCAGGCACCGTGACGCTGAGCCTCGGTCGGGTGTCGAAGTACCGGTCCCGCAGCGACCCCCTCCCGCGGATCCCGGACCGCCCCCAGCCGACCCTCCGGCCAGCGCGCATCAGCGTGACCCGGACCGCCCGGTTCCGGCGAGCTACCCCACGCCGGGTGCGGCGGGACACCATGCCCAGCGGGCCGTCACCGCCGCTGCCGCTGCCGCTGCCGCTGCCGTTGCCGCTGCCGCTGCCGTTGCCGCTGCCGTTGCCGTTGCCGGTGTCGTTGCGGTCGACGTTGCGGTCGACGTTGCCGCTGTCATCTCCGGCCGTCGTGGTGGTGCTGTCGAGCATGACGTCGCTGAAGATGTCGGCACGCAACTGCGCCAGAGTACGCACCTCCAGCGGCCCCTGCAGGGCTATCGCCGTGTCGGTGAGGCGGGTGAAGATCGCGACAGCCTCCGGTGCCGGGAGCAGCTGCGACAGCAACGCCAGACCATCCTGCTGCGGGTCCAGACGCACCTCCCGGTCCTCCCGCGCCCGCGCATGGCGCTGTGTGATCGAGTCCGGATCCAGCAACTCCCGCAGAACCCGCGCCTTCTGCGTAAACTTCGACGCCGTCAACCGTCTCGCATAGGGCAGAGCCTGCCCCTCCAACACCACCCGAGCAGCAGCAGGCAGACCTGCGGTCTGATCGACCATGACCTGCGCATGCCGGTAACTGATCAACCCTCCCCGCAGAGCCTCGAGGGTGGCCGGGAGTTCATGGACCAGACTGCGACCGACCCCCAGCAGAGCGTCGATGGTGCGCTCCGGGATCCGCAACGCCGCCCCCAGCTCCGCCCGCACACTCCGCAACGCCAACTGCCGGCTGCCCGCCCTCGTGCGATCCGTGCCCGCCTCGGCCAGCACGAGGGCCTGCTCGAACAACACCGCCCGATCACCCATCAGCCCCGCAATACCCTGCTCCACCCGCTCCAACGCATCGATCAGCCGCCCCATCGCCTCACCCGCCCCACCCGGCCCCGCCGCGACCCCAAACGGATACCCACGACCACCATCAAGCCCAGCACCGGCCTGGACGGCCTCGCCGGCCTGGCTGGCCTGGCCGGGCTGGCCGGCCTGGCTGGCCTCGCCGGCCCGGCCGGGCTGGCCGGGGCAGTCGGGGACGCCCGGGTAATCGTCCTCATCAGCCCAGCGCGGGTCATCCAAATCCGGATCATGCGGGAACAACCCCGCCGGCATCCCCTCAAACGGCAAACCAACCCCCGGCCGGTACCCACGTGCCGCCATCTCCGCATCCGCCTCGATATTGAACTGCAGCATCGACTCAGCAAGCTCCGCCTGCTCCTCCGCCGTCCACCGATAGCTGCTCATACCCATAGTGAATACCCACCCACCGACACTCGACACGCCCAAACCGGACCGTGCGCGCCGAGCCACAAGCCCCACACCGACACCCGGATTCCGTTCATGACCACAGCCCACACCCCACCACCGACATACCACCGACATTCCCGCCACCCCCGCGAAAGCCGCGGAAAACTACCCCCGCCGCGACCCTGGGGAGGACAAGACAGCCGTGTCCACGCCGCCCGCGCCTGGAGCCAGCAGCGGAGCCCTACAGCCGATCCACCCGGGCGGGGTGCAGGCGCGAGGCCCCAGGCGGCCCCGCCGCCCACCCTCCTCGAGCCGAGGACAGGCCGCACCGCTCCCGCTCCGGGAACGACACGACGGAGCATCGCCGCCGGATACGTCTAGCCCAGGGCGCGCTCGAGCGTGACGGTGGCGTGGGTCAGCGTTCCGGCACCGTCGTCGAGGGTTACGGTATAGATTTCGCTCGGGTTGGCGCACTGGTACGAGATGTCGGTGAACACGCCGGAGGTGTCGACCTCCGCGAACGGCTCGGCCTTGGCGTCGTTTGTGCCGACTCCGATCCACGCAGCCTCCGCGCCGGTGCTCGTCCATTCGAACGTCAGCGGGATCGACGACGTGTCATCCGGGCAGCTGACCGGAGTCCCGCTCTCCGGGGAGAACGTCGTGAATGCCGCGCCCTGGTCGTCCACCGGCTCTTCGCTCTGCGTCGGGTCAGGGACTGGCTCTGATTCCGGTTCCGACGGAGTTGGCGTCGGAGTGGGGACCTCGGATGCCTCGGGAGACGCCGCGGGCGCGGGCACCGTTTCGGGGTCGCGCGTCGCCAGGTTGTACAGCAGCAGCGCGAGAGCGAGAAGAAGCACGGCGGCGATGACAATAAACGCGATCATCGGACCTCGCGACGTGGTCGCGGTCCGCTCCGCGAGCACGGGACGCGGACCCTGCGGACCTTGTGGCGGCGGGAGTCGCTGCGTTTCGGACCTGCCCGATGGCCCTGCGAAGCGTTCGGTGGGAGTCTCGTCGCCGGCTGGCGCGCCCGAAGCCGTGAACTTTTCGGTTGGCGCGTCGTCGCCGGCATGGTCAAAACGGCGGGTGCGAGCGTCGCCCGAGTCGGGTGGCGTGTCGTCCGAGTCGGATGCGGGGGTCGTCGGATCGGGCGCGTTCGGATCGAATCGCCCGGTCGGAGTGTCGTCGCTCATGATCGCTGCGTTTTGTGTGGGGTCAGCCGGTCGGGGCTTCGCCGGGGACGATGGGAAGCGCAGGTTCCGCCGGGGGATCGGTCGCGGCGGGCGGCGGCGTTGTCTCGGTCGGTGTCGGTGTCGGTGCCGGTTCTGGTGCCGGTTCGGGTGTCGGAGTCGGAGTAGGGGTGGGTTCCGGTGTCGGTTCCGGGGCCGGCGCGGGGGTGGGTTCTGGTGCCGGTTCTGGTGCCGGTTCGGGTGTCGGTTCCGGTATCGGCGTGGGCTCCGGCGTCGGCGTCGACTCGGGCGTGCTAGTCGGTGTCGGCGTCGAGCTCGGCTCCACGGATGGCCCCGGAGCGACCTGCGGCCCGTCGGCGCGCGTGACGAGGGTGAAGATGATCATCGTCGCGGCGACGGCGATGACCGCGCCGAGGATGAGAACCGCGATGAGAGGTCCGCGCGACTTCGCGTCAGCATGGGATGGGTTGACCGGCGCGGCGTCAATTGGAGCAGTGGCTGGCTGCGCGGCCCGAGACGCGCCGAAGAGGGCGGTGTCGAACCCGGCCGCCCCATACCCCCCGGCGGGCGTCGGGGGAGTGAACGCCTGCGTGGCGCCGGTCGGTGGCGTGGCCCCGAGAGGCTGGGTTGCCCCGAGTTTGTCGGCGCCGAACGGCGTGGCGCTATAGAGGCCTGTCCCGAGTGGGGCGGTCGCGGCGCCTCCGGATTGATGGTCGAACGTCTCAGTGGCCTGTCCGTCACTGGGCTCGCCATCACTGGGCTCGCCATCGCCGGGCTCCCCATCAGCGGGCTTCCCATCGGCGGGCCCCGCGTCGCCGGCGTCCGCGCTCGAGATCGTCTCGGTGGGGGCATCCTCCGGCTTGCCTTCGGTGGGCGGGTTGTCGTCGCTGCCTTTGCCGGTGGGATCGAGCCGCTCGGGCGGGGTGTCGTTGGTCATTCTGCCCCTCGGATGCCGTCGCGGACGATTCCGCGAGCGAATACAACGGTGGCCGCGGACTACCGCGGCCGGGGCCAGCCTAGGCGGGCAAGCCCGGACCTCACAATTCGCCGGGCGGCATGGCGTCGATGGCGGCTTGAACCCCGTGACACAGTGGCGCCAGCGCTGCCGAAAGGTAGGGCCCGAGCTCTCCCCGCTTCGTGCTCGCGTCTGCCCACGTCTGGGCGGCCGCGATGACCGCTCCGATCGCCCCGAAGCTCGCTGATCGCGCGATCAGCGCCGACTCGGCATCGCCCCCGATGCGTGTCGTGATGAACTCGCTCAGAACGCGCGCCTGGCTCGCGAGCCTCGACATTGCTGACGACTGGAGCTCGCCGATATCGCCGACCAATGTCAGGTGGGTGAGTGCCCACGGCACCTTGGCTGGCCCCAGCGCCGTGCTGGCCGCAACGATCGCCGAGCACATCGCCTGCATTACCGGAGCGCGAGCATCCGTCGCGGCGAGGGCGTCCGGCAGGCGCGCGAGCACGTCGTCGAGGTCGATCCAGAACACGTCGCTCTTCGCCGAGAAGTAGTTGAAGAACGTCGCCCGGCTGACCCCGGCGCGCTGGGTGATCTGGGCGACGGTCGTGCCGGCGTAGCCGTTCTCGAGGAACAGGTCGAACGCGGCCTCCTGCAGCATTTCGCAGGACGACGCGTGGGGTCGGCCGCGCGCGTTCGTCAACGGACCCCCTTTAATCGACTGAGTCCACTTATTGTAGGATGGTTGTATTCCCCAGCAAAAGAATTGAGATTCACGCATGCCCGCTCGCTACCCACGCTCGCTCAGAACAGCAGGGGCCGTCGCCGCCCTCGCGATTGCCGGATTGCTCGCGGGATGCACCGCGGCGAGCAGCGAGGGCGACCAGCAGTCGCTCACCTACGCGATCGAGGGGGCGAACCTCAGCGCCGGACACATGGACCCGCACTCGAGCCAGCTTGATGTGAGCGCGCTCGTGCAGCGGGCAGTCTTCGACTCGCTCGTGGCCCAGGACCTCGACGGAAGCTTCCAGCCCTGGCTCGCCGAGAAGTGGGAGATCTCCGAGGATCAGCTGCACTACGAGTTCACCCTGCGCGAGGATGTCACCTTCCACGACGGAGAGCCCTTCAACGCCGACGCGGTCGTCGCGAACTTCGAGCACGTCACCGCGCCGGAAACGGCATCGGCCCAGGCGGCGAGCATGATCGGCTACAGTGCCGACGGCGGCTCCTACCTCGGTGCGGAGGCGGTCGACGAATTCACCGTGCGATTCGACTTCAGCACGCCGTACGCACCGTTCCTGCAGGCTGTGAGCACCTCGCAGCTGGGCTTCTACTCACCCGCGGTGCTCGACGAGAAGGCCGACGAGCTCAAGACCGGCGGCCCCGGCATCTCGGTCGGCACCGGCCCGTTCGTGCTGAGCGAGTACACGCCCGACCAGGAGATCGTCTACACGGCGAACCCTGACTACGACTGGGCGCCCGAGAGCGCGGAACACAGCGGCGCGAGCGACCTCGACGAGCTCGTCGTGCGCATCCTGCCGGAGCCCTCTGTGCGCACCGGCGCGCTCGCGAGCGGCGAGGTGCAGGTGGCTGGCAACGTGACCCCGAGCACCGTAGGAAGCCTCGGCGACGACATCACCGTCAACTCGGTCGAGCTGCCCGGGCTGCCCTACTCCCTCTACCTCAACCAGAACAACGGCGTGTTTGCCGATGTGAAGGTGCGCCAGGCATTCCAGCTCGGGTTCGACCCGCAGGATGCGGTCGATGGCATCTTCTTCGGCCAGTACCCGCGCGCCTGGAGCATCCTGGGCCCGACGACCCCCGACTCTTACGACAGCTCGCTCGAGCAGCGCCCAGCCGTCGACGTCGACCGCGCGAACGAGCTGCTCGACGCGGCCGGCTGGACCGAGCGGGATGCCGAGGGCTACCGCACGAAGGACGGCGAGCGGCTGAGTGCCCGCTGGATCGCGTACACGCCCATCCCGGACGACCGGGCGAGCCTCGCCGATGTCATCCAGTCCGACCTCAAGGGGATCGGCTTCGCGATCGTGCGCGAGGCGCTCGAACCGGCCGCCTACAACGAGCAGTACGGACCCAAGACGTTCGACATCACCGACTGGGGCTTCTCCGGCGTCGACGCCGACCTGCTGCGCAGCCACCTGCACACTGACGGGTTCCAGAACGCGTCGGGCCTGAGCGATCCCGCCATCGACACCCTGCTCGAGGATGCCGTCGCGACGAGCGATCCGACCGAGCGCGCGGCCCTCTACACCGAGCTTCAGCAGTGGAACGCCGAGAACGTCGCGATCGTGCCGCTGTACGTGCCGTCGATGATCACCGCGTTCAGCGACTCGGTCACCGGCCTCACCTTCGATCTGTATGGCCGACCGCTGTTCTACGGCGTCCAGGTCCAGGGGTCGTGAGGCTGGGCCCGTCGAAGCGTCGAGTGCCCGGTGCGTCAGCGCGCTGGCTTCTCGGGCGCCTCGGCGGGCTCCTTCTTGTGGTCTGGGGCGCGGCAACGGCCGGGTTCCTCGCGCTGACCCTCATCCCCGGCGACCCGGTCGACGTCATGCTGGGAGTGCAGGCGCAGGTCAGCGAGCAGGTCAAGGCGCAGATCCGCGCGGATTGGGGCCTCGACGACCCGCCGCTCGCCCGCTACCTGCAGTACCTCGGGCGTCTAGTGACGGGCGACCTCGGCGAGTCGTACCAGCTGCGCCAAAGCGTCTCGTCGGTGATCGGCGAGCAACTGCCCGCGACTCTGCAGCTCACTCTGCTCGCCCTCGCCTTCGCTCTCTCGCTCGCGGCGATCGCGACACTCGCCGCACGCGGACGCCGCTCCACCCGCATCGTGTCGCTTGTTGAGCTCACCGCCGTCTCATCGCCGACGTTCTGGACCGGCCTCGTGCTCATCGCCGTCTTCGTCTTCCAGCTCGGCTGGTTCCCCATCGCAGAGACGGGCAGCCTGCGCGCCCTCGTGCTGCCCGCGCTGACCCTCGCCCTGCCGGTCGCCGGAATCATCAGCCAAGTGCTCCGACAGGGGCTGGATGCCGCGTCGGCGCAGCCCTTCGCAACGACCGCCATCGCGCGCGGGCTCGGCGGCGGCCGCCTGCTGCTCCGGCACACCCTGCGGCACGCTGCGGCCGATAGCGTCACCCTCGTCGGCTACCTCGTCGGCACCCTGATCGGCGGCGCCGTGCTGGTCGAGACGGTCTTCGCGCGGCCGGGACTCGGGCGGGTCACCCTCCGCGCGATCATCGACCGCGACCTCCCCGTGGTGCTCGGGATCATCCTGCTCGCCGCGGTGACCTTCGCCCTCCTCAACCTCGCCGTCGACGTGCTCTACCGATGGATCGACCCGCGCCTGCGCACCGGGAGCGCGGCGACATGACAGTGACACTCGGCAGGACCCGGCTCCGGCCGCCGCGAGCCGGGCTCGCGGGCGCGATCGCGGCATCCGCGTTCCTGCTCGTACTCGTCGTCGCTGCCGCGGCACCCGCCCTGTTCACGAGCGCCGACCCAATCCAGACGCAGGTGCTGCAGGCGCTGCGGGCGCCGAGTGTCGAGCATCCGTTCGGCACCGACCAGACCGGGAGGGATGTCTTCGCGCGCGTTGTCTACGGCGCTCGCTACTCCCTCGCGATCGGGGTTCTGGCAACGACGATCGCAATGACCGCGGGGCTTCTGGTCGGCACCCTCGCGGGCCTCGCGCCACGACTGGTCGACAGCGCGATCTCGCGAGTGATCGAGGTGCTCATGTCATTCCCCGAGTTTTTGCTTGCGCTGCTCGTCATCGCAATTCTCGGCCCCGGCCCGGTGAGTCTCGTCATCGCGATTTCCCTCGCCTCCGTGCCGGTCTATGCACGGGTTGCGAGGGTGCAGACCTTCACCGTGCGACGTTCCGGCTACGTGCGTGCCGCGGTGATCCTCGGGGTGCCGAGATGGCGCAATGTGCTTCGCCACGTTGTGCCCAACACCCTCGGCCCGCTGCTGGTGATGGCGACGATCGGTTTCGGAACGGCGATCGCGTCGGCCGCCGGCCTGAGCTTCCTCGGTCTCGGCGCGCAGCCGCCGACACCCGAGTGGGGCCTGATCCTCTCGGAGGGGCGCAACTTCCTCGGCACCGCCTGGTGGATCGCCGTGTTCCCCGGACTCGTCGTGACCGTCACGGTGATCTCGGCGAGCGTGCTCGGTCGCTACCTTCGGGCGCGTGGAGAGGGGAGGGCGGCATGAGCTTCGTTTCCGTGCGCAACCTTCGGGTGCGGTTCGGGCGGAGAACCGTGGTCGACGGGGTGAGTTTCGACATCGCTCCCGGGGAGTGCCTCGCGATCGTCGGGGAGTCGGGATCGGGGAAGACGATCACCGCCCGCGCCCTGCTCGGCCTCGCGCCCGACGGCGCAGACGTCAGTACCGACGAACTCGTGGTGGCCGGTGTGGACGCGTCGGCCTACACCGGAGCCGAGTGGCGCTCGGTCCGTGGGCGCCTCGTCGGCCTCGTAAGCCAGGACGCCCTCGTCTCGCTCGACCCGATGCGTCGGATCGCGAGCGAGGTCGCCGAGCCAATAGAGGTGCACGAGGGCGGGCTCTCGCGCTCCGAGGTCGACGCGCGGGTGCTGCGGATGCTCTCGAACGTCGCGATTCCCAGCCCTGAGACGCGCGCCCGGCAGTACCCGCACGAGCTTTCCGGAGGGCTGCGGCAGCGCGCACTGATCGCCTCCGCTCTCGCCGCAGCACCCAGGCTCCTCGTTGCCGACGAGCCGACGACGGCGCTCGACGCGACCGTGCAGTCGAAGATTCTCGAGCTGCTCGGCAGCCTCAAGGAGGCGGGGCTCGCGCTGCTGCTCGTGAGCCACGATCTCTCCCTCGTCTCCCAGATCGCCGACCGGATCGCGGTCATGCAGCACGGCCGCATCGTCGAGACCGCCGCGGCCGCCGACCTTCTCGCCAACCCCACGCATCCGTACTCGAGGGCATTGCTCGACGCCGTGCCGACCGGGCACGCCGTACGGCGCGACGGGGGCGAGATTGTGCTCGCGGCACGCTCCCTTGTGAAGCAGTACCCCGCACCGCACCGCACCACGACGGTGGCCCTCGACGACGTGTCGCTCGAGCTGCGGGCAGGCACGACGCTTGGCATCGTGGGGGAGTCGGGCTCCGGCAAGAGCACCCTCGCCCGGCTGCTCCTCGCGATCGAACGCCCGGACTCCGGTGAGGTACTGCTGCGCGGCAGCCGATGGAGCTCTCTCGCCGAGTCCGCCCGGAGACGGATGCGCGGCGGCATCCAGCTCATCGAGCAGGACCCGGCGTCGTCGTTCGACCCGCGGTACACGGTGCGGCGCATCCTCGCCGAGGCCGTCGCCATCACCGACACACGCGCCAACCGCCCGGCCCGCATCCTCGAGCTGCTCGAGCAGGTCGGGCTCTCGGCCGTGCACCTCGGGCGACGCGGCCACGAGCTCTCCGGGGGGCAGCGCCAGCGGGTCGCCATCGCGCGCGCACTCGCCCGGCGGCCGAGCATCCTCGTCTGCGACGAGCCGGTCTCTGCGCTCGATGTGCAGGTGCAGGCCCAGGTGCTCGCCCTGCTCCAGAACCTGCAGGCGAGCACCGGACTCGCGCTCGTGGTCATCTCCCACGACCTCGCCGTGATCGCCCAGTTGAGTGACACTGTGCTCGTGATGCGCCACGGTGTTGTCGTCGAGAGCGGCGAGGCGAGCGAGGTTCTGACGAACCCGAACCACCCGTTCACGCGGGAGTTGCTCGACTCGTTACCTGCGGGCCGTATCCTGCCCTGATGACCAGCCGTCCCTCCCTCGCGCGGAAGCTCGGCCTCGCCGATGCCGTGTTCATCGGTCTGGGCTCGATGATCGGCGCCGGGGTCTTCGCCGCGTTCACCCCCGCAGCGCACGCGGCAGGAAACGGGCTGCTGATCGGGCTGGTGGTCGCCGCCGTTGTCGCGGTCTGCAACGCCCTCGCGTCGGCGCAGCTCGCCGCCGTCTACCCCGAATCGGGCGGCACCTACGTCTACGGGCGCCGGGTGCTCTCGCCGTGGTGGGGGTTTCTCGCCGGCTGGAGCTTCGTCATCGGCAAGACCGCGAGCTGCGCGGCGATGGCGCTCACCTTCGCCTTCTACGCCGCGCCCGCCGGGTGGGAGCGACCGGTCGCGGTCGCCGCGGTGGTGGGCCTCGCTGCCGTGAATTACCGCGGGGTGACCCGCACAGCCGCGCTCACCCGGGTGATCGTCGTGGTCGTGCTTCTCGCCCTCGCCGTCGCGGTCGCCGCCGGCGGCAGTATCATCGGCGGCCCAGCGGGGTTCGCGGAGGCGACCGATCCCGGCGGGCTGCTTGCCGGCGGCGGATACGGAATCCTGCAGTCGGCCGGCCTGCTGTTCTTCGCCTTCGCCGGCTACGCACGCATCGCCACGATGGGCGAGGAGGTACGCGACCCGGAGCGCACTATTCCGCGCGCCATCGTGATCGCGCTGGCCATCACGGTCGTCGTCTACGGCATCGTCGCCGTCACGCTGCTCGGCGTGCTCGGCCCCGATGGGGTGGCCTCCTCGGTGGCGCCCCTCGCCGACACCGTTCGTGCGAGCGGATGGGACTGGGCTGCCCCTCTCGTGCGGCTCGGGGCTGCGGCAGCGTCCCTCGGCGCACTGCTCGCGCTCTTCGCCGGGATCGGCAGGACGACCCTCGCGATGGCGAGGGAGGGCGACCTTCCAAGCTGGCTCGCGTCCGTGCATCCGAAATTCTCCGTCCCGCACCGTGCGGAGGTCGTGCTCGCCCTTGTCGTCAGCGTGCTCGTGCTCACCGTCGATCTGCGCGGGGCGATCGGATTCTCCTCGTTCGGAGTATTGCTCTACTACTTCGTGGCAAATGTCGCCGCGTTCCATCAGCCGGCGGCCGAGCGCCGCTACCCGCGCGCGCTGCAGGTGCTCGGGGCGGTGGCGTGCGTGATCCTCGTCGCGACCCTGCCGCCCGTCGGCATCGCCGTCGGCGTCGGGGTGCTGCTGGTGGGAGCGGCCTATCGGATCGCCTCGATGCGGGGAACCGCGCGAACGTGAGAGTAAGGGTCCGGGGCGACACACGTCGCGCGCACGAAAAATGGCCGCCCGCAAAGCGGACGACCATTTCACTTATCGAGTGGGAATCAGGAGGTGAGGCCGTCAACCCATTCCTGGTTCTCGCCGATCCAGGTCTGCACGATTTCCTCGTACTCGCTCGCGTCCGCTCCGCTGCCGAACATCTCGTTCTGCAGGGAGTCGAGCGGTGCGGTCTCCATCTCGAAGTCCTCGAGCCAGCCGTTCAGCGTGGGGTAGTCCTCGCCGAAGCCGGTACGCGAGAACGTGTGCAGGCCCTCGGCGTCGCCCAGCGCGCCCTCGGGGTCTGCGAGGTCCTTGATCGGGAACGCGTCATAGGCCCAGTGCGGGTGCCACAGGGTCACGGCGATGTTCTCGCCGGCGTCCGTCGCTGCGGTGAGTTCGGCAAGCATGGCCGCCGTCGACGACGTGGTGAGCTCGAACGCGTCGAGGTTGTACGTCGGCATGACGTTCTCCTGCGTGATCTTCGTGAGGCCCGCGCCCGGCTCGATGCCGATGATGCGGTTGCCGAAGAGGTCGCCGTTGTCGGCAAGCTCGGCGAGCGAGTCGATCGGGGCGTCCTCGTTCACGGCGACGCTGAGAGTCGCGTCGGTGTTCCAGGTGCCGACGTCGACGATGTCGTCGCCGTACTCCTCGAGATACTCCGCGTGGGTGCCGGGCAGCCACACGTCCATGTTGAGGTCGTAGTCGCCGGAGGAGAGGCCGACGAAACCAGCCGCGACATCCGCATACTCGAGTTCGACGTTGTAGCCCTCTTCCTCGAGCACGGCGGCCCAGAGGTGGCTTACGGCTTCGCCCTCGGGCCAGCCGTTGAAGACGGCGATCGTGACGTCTTGGGCGTCACCGTTCTCGAGGCCCGATGCGTCGGAACCGGCGTCGGCGTCTGTGGAGCACCCGGCGAGGGCGATGAGTCCTGCGGCTCCCGCGAAAGCGAAAGCGGTCTTGATGGACTTATTCATTATTGCCTTTCCTGTTGCTGTTGCTGTGTTGACGGGGAATTTCTAGACGGATGCGCCGACGGGGGCGTCCTTGGTTGCCGCGGCAGGCGCCGGGGAGGGTGCGGTCTCGGTGGGGGTCACCTTCCGGCGCCAGGGCGTCCACATCTTGCGGCGCTTGCCGCTCAGCGCCGCCGTCAGCCGGTCGAGGTAGATCGCGATGATCACGACCGCCAAGCCGGCCTCGAAACCGAGTGCCACGTCGATGCGGCTGAGTGCCTGCACGACATCGCTGCCCAGTCCGCCGCCGCCGACGAGTCCAGCGATGACGACCATGGAGAGGGACAGCATGATGACCTGGTTGATTCCAGCCATGATCGTCGGCATCGCGAGGGGGAGCTGGATCTGGCGCAGGATGCGCCACGGCGAGGAGCCGAAGGCGTGGCCAGCCTCGACGACCTCCGTGTCGACCCCGCGGATGCCGAGTTCGGTGAACCTGACACCTGGCGCCAACGCGAAGACGATTGTCGCGACGATGCCGGGCACGACGCCGATGCGGAAGAGGATCAACGCGGGCACGAGGTAGACGAACGCCGGCATGGTCTGCAGGAAGTCGAGAATCGGTCGGATGACCGCTGACGACCGGTCGGAGCGCGCGGCAATGATGCCGAGCGGCACGCTGATTGCGATCGCAATGGCGCTTGCCACGAGAACGAGCGCGAGGCTTGCCATCGCGTTGTCCCATTGGTTCACCCCGACGATCACGAGCAGTCCCACGATCGTGCCGAGGGCGAATTTCCAGCCCTTCACGAAGTATGCAAGTCCGGCAGCGATGAGGATGATGACCCAGAATGGCGGGCTGAGCAGTAGGAACTCGACGGCATCGTAGAGCGCGAGCAGCACGAACCTGATGAGGTCGAAGACGGGGCGGAGGCTCTCGGTCAGCACATCGATGCCCTCGGAGACGATGTCGCCGAGGGGTAGGCGGAAGTCGGTGATCATGCGAGGGTCCCCTCGGTGGATGCTGCGGCAGGGGTCGGTTCGGGGCTGGCGAGCATCGCGTCGAGTTCGGCATCCGGAATGATCGAGACGGGCTCGATGATGTTGATCGGTGTCGTGTTCGTCGGTACATTCCCGAGCGCGGCGAGCAGCGTGATCCGCGGGATGACCCCGAGCAGACGGCGCTTGTCGTCGATGACGGCGATGGGCAGCGGGCTTTCGACGGCGAGCTCGAACAGGTCGACGAGCGCGGCATCGGCCGGGACCGACGCGTGCTCCTGGTTGATGACCAGGGAGAGGTCGGTCTCGTTGCTCTTGACCTGGCGCATGACGTGCCGGTCGGTGACGACGCCGAGCAGGGTGAGGTCGCGGCCGAGTACGAACGCGGCCCCAGCCTGCAGATCACGCATGACCCGCAGCGCACCGCGGGGCCCGGCGGTGAGCGGTACGACGGCGCGGGCCGGCTCCATGACGGTCGCCGCGGTGAGCACGCGGGCACGGTCGACGTCCTGCACGAACTGGGCGACGTAGTCGTTCGCCGGGTCGGTGAGAATATCCTCGGGTGTGCCGATCTGCACGATGCGTCCGTCGCGCATGACGGCGATGCGGTCGCCGAGGAACATCGCCTCGTTGAGGTCGTGGGTGATGAAGATGATCGTCTTGCCGAGTTCGGCCTGCAGTTCGAGAAGCTGCTCCTGCATTTCGCGACGGATCAGTGGGTCGAGCGCCGAGAATGCCTCGTCCATGAGCATGATGTCGGTCTCGGTGGCGAGGGCGCGGGCGAGGCCGACGCGCTGCTGCATTCCGCCGGAGAGCTCCGACGGGTACTTATCAGCCCAGCCGTCGAGCCCGACGATGTTCACGATCTTGAGGGCGCGTTCGAGTCGCTCGGCTCGGGGAATACCCTGCACCTCGAGGCCGTAGGCCGCATTGTCGAGCACCGTGCGATGCGGAAAGAGCGCGAAGTGCTGGAAGACCATCGAGACGTTCTTCTGGCGCACCTCGCGGAGCTTCGCAGGCGACACGTCGGAGATGTCGATGCCGTTGACCGTGACGGATCCGCTCGTGGGATCGAGCAGACCGTTCAGGGTGCGGATGAGGGTGGACTTGCCCGAACCGGACAGTCCCATCACGACGAAGATCTCGCCCTTCTTCACCTCGAACGAGGCGTCGATGACCGCCGCGGTCTCGTGCGCCCCCAAATCAGAGCGACTCACGCCATCTTGGAGCTTCTTAACGGCATCCTTCGGACGCCGCCCAAAGACCTTGTACAAATTCTTGACTGAAACTGAAGAGGTGCTGCTCACGTTTTCCTTTGGCGCACGCACACACAAAATTCGAGCGAGGTGGCTTTGCTGTCGTGGACGGGTCGGAATCAACAGTGCGAGTGGCTACTCAAGCGGCGACACAATGGGGTGCCAGCGGCGAGCAAGACTTGTGCAGAACAGCCAAAAGGCTGCGTGAATTCACGACCATACGCCTCAGAAAAGTCCCTTTTCGGGACTGTCCTGGGCCGCGGCCTTGGTGTGGGGTGATGAAGAGTTCGTAGGCAATTATAGCCGCGGCTTTGGCTTGAGGGCAATGATCATGCTTGTCAACCCCGTGCTTTTACAGGGGTAGACAGAACTGTGTCGCCGCGCTGGCAGCGATCCGGGAGGTCGGGACCGTTGTGTGTTTGTTATCTGCCCCTCGAGCATCCGGCTAGAATCGACAGATCGACAGCGATCCGGCCATCACCGGGGAGTCCTCGGAAGAGAGGCCGAATCCCCCGGGATGAGGCCCGGTAGAACCGAGCGGGTCTGGCCCGTCAACGCCAACGAAATGAGCGGTTCCACTTCTCGTGGGGCAAGCGGGGTGGTACCGCGACATCCCGGTCTGACGGCCGGGGAGTCGTCCTCGTGCAGCACAGGCCCACTGTGCACCAAGCCTGCCGAGGAGAGACATGAACTACCCCAAGGGATTTAGCCCGGATGCCGGCGCAGCGCGACCGGTCTCGCCGTCGCCGAACTTCCCGGCCATCGAGCGCGGCATCCTCGCGTTCTGGAAAGGCGACGAGACCTTCCGCGCCTCGATCGAGAACCGCGAGGGCTGCCGTGAGTGGACCTTCTACGACGGACCGCCGTTCGCCAACGGACTGCCGCACTACGGCCACCTCCTCACCGGGTACGCAAAGGACCTCTTCCCCAGGTTCCAGACCATGCGCGGGCTGCAGGTGCACCGCCGATTCGGCTGGGACACCCACGGGCTGCCCGCCGAGCTCGAGGCGATGCGCCAGCTCGGCATCACCGAGAAGCACCAGATCGACGAGATGGGCATCGCCGCGTTCAACGATGTGGCCCGCAAATCGGTGCTGGAGTACACGGGGGAGTGGGAGGAGTACGTCACGCGGCAGGCCCGTTGGGTCGACTTCGAGAACGACTATAAGACCCTCGACGTCACCTTCATGGAGTCCGTGATCTGGGCCTTCAAGCAGTTGTACGACAAGGGCCTCGCCTACGAGGGATTCCGGGTGTTGCCGTACTGCTGGCACGACCAGACGCCGCTCTCGAACCACGAGCTGCGCATGGACGACGACGTCTACAAGATGCGCCAGGACCAGTCGGTCACGGTCACCTTCCCGCTCGACGGCGTCAAGGCCGAGGCGCTCGGCCTCACCGCCGTGAAAGCCCTCGCCTGGACGACGACACCGTGGACGCTGCCCACCAACGCAGCCCTCGCCGTCGGGCCGGACATCGAGTACTCCGTTATCCCGAGCGGCCCGCTCGGCGCCGGCGATGGGTCGGCCGAGGGCGTGGCCTCCTACCTCCTCGCGAGCGACACAGTCGGCGCTTACCTCAAGGACCTCGGCTATGCCTCGATCGACGAGGCACGCGCCGCCGTCACTTCGACGGTGCTCGGCAGCGAGCTCGACGGTGTCACCTACGACCGGCTGTGGGACTACTACGCCGACGCCGAGGAGTGGGGCACCGAGAACGCCTGGCAGATACTCGTCGCGGACTACGTCGCGACGGGCGAGGGCACGGGTATCGTGCACCAGGCACCCGCCTACGGCGAGGACGACCAGGTCGTGTGCGCCGCCGCCGGCATCCCCGTCATCATCTCGGTCGACGACGGCGGCAAGTTCCTGCCGCAGATTGAGGAAGTCGCGGGGCTCCAGGTATTCGAGGCCAACAAGACGCTCATCCAGCTGCTGCGCACCGGCGGGCGCCTGCTGCGCCTCGCCAGCTACGAGCACAGCTACCCGCACTGCTGGCGCTGCCGCAATCCGCTAATCTACAAGGCCGTCTCGAGCTGGTTCGTACGCGTGACGCAGTTTCGCGACCGGATGGGCGAGCTCAACGAGCAGATCAACTGGGTGCCCGAGAACGTCAAGCACGGCCAGTTCGGCAAGTGGATCGGCAATGCCCGCGACTGGTCGATCTCGCGCAACCGCTACTGGGGATCTCCCATCCCGGTGTGGAAGAGCGACGACCCCGAGTACCCCCGCATCGACGTCTACGGCTCGCTCGACGAGCTCGAGGCGGACTTCGGGGTACGCCCGACCGACCTGCACCGTCCCTACATCGACGAGCTCACCCGCCCCAACCCGGACGACCCCACCGGTACCTCGACGATGCGTCGCATCGAGGACGTCCTCGACGTCTGGTTCGACTCCGGCTCGATGCCCTTCGCGCAGGTTCACTACCCGTTCGAGAACCAGGACTGGTTCGAGAACCACAACCCCGCCGACTTCATCGTCGAGTACATCGGCCAAACGCGCGGCTGGTTCTATACCCTGCACGCCCTGTCGACGGCGATTTTCGACCGCCCCGCGTTCAGCAATGTCGTGAGCCACGGCATCGTGCTCGGCTCCGACGGGCAGAAGATGTCGAAGAGCCTCAACAACTACCCCAACGTCAGCGAAGTCTTCGACCGTGACGGTGCGGACGCGATGCGCTGGTTCCTCATGTCGAGCTCGGTGATCCGTGGCGGCAACCTCGTCGTCACAGAGGAGGGCATCCGCGAATCCGTACGGCAGTTCATCCTGCCCGTCTGGAACACCTGGTACTTCTTCACCCTTTACGCGAACGCCGCCGGGTACGACGCGACCTGGCGCACGGACTCGAGCGATGTTCTCGACCGGTATCTGCTCGCCAAGACCCGCCTGCTCATCCACGAGGTCGAGGCGCAGCTCGAGGCTCTCGACAGCCCGGCAGCCACGGCGACCCTGCGCGACTTCGCCGATGTTCTCACCAACTGGTATGTGCGCCGCAGCCGCGACCGGTTCTGGGCGGGCGATGACCGCGACGCGTTCGACACGCTCTACACCGTGCTCGAGACGGTGACCCGGGTCGCCGCCCCGCTCATCCCGCTCATCGGCGAGGAGATCTGGCAGGGGCTCACCGGCGGACGCAGCGTTCACCTCACCGACTGGCCGGACGCCGGGGCGTTCCCGGCGGACGCCGCGCTCGTCAGCGCGATGGACCGGGTGCGGGAGATCGCCTCCTCGGCGCTTGCCCTGCGCAAGGCGACCGGCAAGCGCGTGCGGCTTCCGCTGGCCGAGCTCACGGTCGTCGCCGAGTCGATCGACGGGCTGTCTGACTTCTCCGACATCCTGCGTGACGAGCTCAACGTGAAGAAGGTCTCGCTCAGGGTCCTCGAGGAGTCGAGCCTGGGTGAGTTCGGCATCACGAAGCGCCTCAGCGTGAACTCTCGGGTGGTCGGCCCACGGATCGGCAAGAACGTGCAGGTCGTGATCAGGGCGTCGAAGTCCGGCGACTGGGAGCAGACCGACGGTGGAGTCGTCGTCGGCGGGATCGAGTTGCTGGCGGGCGAATTCGAGCTCGAGCTGCAATCGGCGGATGACTCGAAGGCGATCGAATTCCTGCCCGGCGGCGGATTCGTGCTGCTCGACACTGCGACGACACCCGAGCTCGAGGCGGAGGGCCTGGCCCGCGACCTCGTGCGGGCGATCCAAGACACCCGCAAGGCCGCCGGTTTCAAGGTGAGCGACCGAATCGACCTGACCCTGTCATTCGGATCCGAGTCGGAATTCTCCGGAACCCGGGCCTATGAGAGCATGATCGGCGAGGAAACGCTCGCGACCACACTCTCGACCTCGTGGCACGCCCCCGTCGAACTCGACACGGCCGCCGCCGTCGCCGGCGAGGCGGGCGCCTACCGGGCCACCGTGCCCGCCGGCCGTTACTCCAACAATGAAGCAATCGTCATCGAGCTGTCGGTGCACGGAAGGGGTGTCGATGTCTAAGAACCGCGACGCAGAAGATCCTGAACTGAGCAACGACGCGCTCTTCCAGGCGCAGGCCGATCGCGTCTACGGCGAGCTGCTGGCCCGCATCGGTGAGGCCAACCCGCAGCCGAGGCTCGGGCCGACCCGCAAGGTGCTCGAGCTGCTCGGCGACCCGCAGCGCACCTACCCGATCATCCACATCACAGGAACGAACGGCAAGACGAGCACGAGCCGCATTACCGAGAGCATCCTGCGTGCCTACGGGCTTCGCACCGGGCTGATGATCAGCCCGCACCTCGTGCGCGTCAACGAGCGCATCGTGGTCGACGGCGAGCCCATCTCGAACGAGGCCTTCGTCGCCAACTGGGACGACATCGCCCCGTACATCGCGATGGTCGACAACGAGCTGATTGAGGCGGGCGAGCTCGCGCTCACGTATTTCGAGGCGCTCACCGCGCTCGCGTTCGCGTGCTTCGCGGATGCCCCGGTCGACGTCGCCGTGATCGAGGTCGGCATGGGCGGCGAATGGGACTCCACGAATGTCGGTGACGGCCAGGTCGCGGTGTTCACCCCGATCTCGCTCGACCACACCCAGCGGCTCGGCAACACCGTGCTCGAGATCGCCAAGACCAAATCGGGCATCATCAAGCCACTCGCGAGCGTTGTCACCGCAGTGCAGCAGCCCGACGCTCTCGCGGTGCTCCGGCACGCGGCCGAGCTCACCGAGTCCACCGTCGTCGCCCAGGGCGAGGAGTTCGCTCTGATCGAGAACTCCGTTGCAGTGGGGGGACAGGTGATCAGCGTCAAGGGCCTCGCTGGCACCTACCGCGACCTCTTCCTGCCGCTGTTCGGAGACCATCAGGCGCAGAACGCCGCGGTTGCGATCGCCGCGGTCGAATCGTTCCTCGGCGGCGGCAGCCAGATGCTCGTGGGAGACGTACTCGCCGAGGGAATCGGCACCGCGACCTCACCGGGACGGCTGCAGGTTGTCGGGGTCGAGCCGAGTGTGCTCGTGGATGCCGCGCACAATCCCGACGGGGCGGGCGCGCTCGCGTCCGCGGTGGCGACGTACTTCACCTTCGACGAGGTCTGCGTCGTGGTTGCCGCGCTCGATGAGAAGGACGCCGCTGGCATCATCGGCGCGCTCACCCCGATCGCGAGCCGTTTCCACGTCACCCGGTCGAGCTCGGCTCGCGCCATCGACGAGGACGAGCTGGGCGAGATCGTGCGCGAAGTGGCCGGACCCGATTCGTACGAGGTCTTCGCTGGTGCCGAGGAGGCGCTCGCGAGCGCCCGCGAGTGGGCGAGGGGAGCGGCGAAGCGGGCCGTGCTCGTCACCGGGTCGGTCACGCTTGTCGGTGACGCCATTGCCATCGCCGATCGCGAGGGCTGGAAGAGGTGAGCCCGCGCGAACGACGGGCGCCACGGCGCAGATCGGCCACCGAATCGCTGCTCTCGATCGTGCTCGTGCTCGAGGCGCTGCTGGTGTTCTTCCTGACCCTCGTCGTGTTCGCGCTCGACGCGCTGCCCCCGGCCGCGGCATTCATCGGCGGGGGAGTGCTGTTCGTGGCTCTCCTCGCCCTCGGGCGCGTCATGCGCTACGAGTGGGCGGTCTGGGTCGGCTGGCTGATGCAGCTTGTCATCATCCTCACCGGCCTGCTCGAGCCGCTCATGTTCGGAATCGGCGCGATCTTCGTGGCCCTCTGGACCTACTGCTTCATCACCGGCCGACGACTCGACAAGCGAAACGCCGCGCTTTTCCCCGACGACAGCACCGATACCTCCACCACCGACACGAAGGAAACCCCATGACACACGTCGAAGAAACACTCGTTCTGATCAAGCCCGACGGAGTCGTGCGCAACCTCACGGGAGAGATCCTGCGGCGCATCGAGGCCAAGGGCTACAAGCTCGTCGACATCAAGCTCGTCGAGGCCGACCGCGGCCGGCTCGGCACGCACTATGAAGAGCACGCTGGCAAGCCGTTCTACGAGCCTCTCCTTGAATTCATGGAGAGCGGTCCATCCGTGGCGATCCGCGTCGCCGGAAACCGCGTCATCGAGGGCTTCCGCGTACTCGCGGGAACGACCGATCCGACCACGGCTGCCGCCGGCACGATCCGCGGCGACCTGGGCCGCGACTGGGGCCTCGCCGTACAGCAGAACCTCGTGCACGGCTCGGACTCCCCGGAGTCGGCCGAACGCGAACTGGCCCTCTGGTTCGACTAGAGGTAACGGATCACGTCGAGTCGCAGCTGGGCGAGCAGCGCGACGACGATGTAGCAGAGCAGGGTGAGGAAGGGCGTCCACGCGTAGGCCCCACCCAGGGCTCGCCGTAGCCTGCCAGGCAAGGGGATCACGCCAGCCTTCACGTTGTACAGGGTCACGGCGATGAACGCGGGAATCGTGACCGACCAGACGACCATGCACCACGGGCACAGCGTGCCCAGGTAGTAGATGCTCGTGCTGATCAGGTAGGCGACGAAGGCCAACGCCCCGAGTAGGCCCAGATTGAACAGTGCCCAGAACCAGCGGGCGAAGCGGGCGCCGGCCAGCACCCCGACCCCGACGGCGATCACCGCAGTGAACCCCGCGAGCCCGATGAGCGGATTCGGGAACCCGAACGTCGACCCCTGGGCGGACTCAAGATTCTTGGTGCACTGCACCAGCACACTGAAGTCACAGCCGGCCGCCTCGCCCGGATTGACAAGTCCGGCGAACTTTTCAAGCGTGAGAGCAAACGCCGCGACGAAGCCGACCACCCCGGCAAAAACCAAGAAAATCGCAAGCGGAATGGGGCGGCTGGTTCGAGCTGTGGAGGTCACTCTCGGATTATCGCACGGAGTAAATGCGGCAGAAATTGCGGGTGCATGCGATAATTTCGGGTAGTCATCCGAGCCGCGCTCGGACGACGCCAAAGAAGGCTTTCCGGGCATCAAACCGGACCGCTCCATTAAGTGCAGCGTCGGATAGCCAGTTCCGTTCAGTGAGACCAAAGACGATCGCCATCAGGGCCAGATGATCCCGGGCCACATATCCGGGATGCCTGCACTACGACCACCGAGCGTGTTCGCACGGTTCGAGGCACCTGGCTGATGGCGCAACCGATAAGAATTCGCGGGAGCTGGCCAGCGCCAGTGAGCGCTCGAGAGAGTACCCGACGGACAGCGCGGCTGGCCGGAGCGGGCTAGGAGTGCACCAGTAATGGTGGAATACAACGAAAACAACGACGAGACACCGCGCAAGCGCAAGGGACTCTTCGGGTCCCGCCGCGTCAGAAGCGCCGATATGGTTCCCGCCGAGCAGTCGGCAGCGCCGGTTCCGGATGCTGTCGAGCCGCGCGAGCAGCCTGCCGCTGAGCAGCCTGTTGCCGAGCAGCCCGCCGCCGAGCAGCCTGCCGCCGAGCAGCCCGTTGCCGAGCAGCCCGCCCTGGAGCAGGCTGTGGCGCAGCGAGCATCCCGCTCACGCCGCGCGAGCAGTGCATCCGCGGCCGCCGCGCCCACGGAGAACCCGACCGAGGAGGCAGCGCCGGCGGAGCCCGTGACGGCGCGCCGCACGCGCCAGAGCGCTGCGAAGTCGACCGCGACCCGGTCCACGGCGGCGAGCCGCGCGACTAAGGCCAAGGCCGAGACCCCTGCCCCAGACGAGGCCCCTGCCGCGGACGGGACCCCTGCCGCAGACGACACCGCAGAGCAGTCGACCGAGCAGTCGGCTGAGCAGCCCACCACGCCCGAGGCACCGGCCGCACCCGCGCGCCCCTCGACGTCGCTCCTGTTCCAGGCGCCCGAGTTGCCGGCCTACGCGCCGCGCCAGCAGTCGCGGGACAACCGCGGCGGCAACGACCGCGACAACCGCGGCGAGTCGCGCGACGACGGCCGTGACGAGGACGAGCAGACGACCGTCCGCCGCCGCTCGCGCCGCCGCTCCGGTGAGGAAGACCGAGACACGGGCAGCTCCAACCCGCGCAACACCGTTGTCAAGGTGCGCACGCCCCGCCCGCAGCCGGAACCGATCACCGAACCGCAGCGCATCAAGGGATCCACGCGCCTCGAGGCGAAGAAGCAGCGCCGCCGCGACGGCCGTGACGCCGGGCGCCGCAGGCCCGTCATCACCGAGGCCGAGTTCCTGGCCCGCCGGGAGAGTGTCGACCGCGTCATGGTCGTGCGGGCGAAGTTCGGCCGCATCCAGATCGGCGTGCTCGAAGACGGCGTGCTCTCCGAGCACTACGTCGCGAAGGCCCAGGAGGCGAGCCTGATCGGCAACGTCTACCTCGGCCGGGTGCAGAACGTGCTCCCGAGCATGGAGGCAGCATTCGTCGACATCGGGCGCGGCCGGAACGCCGTGCTCTACTCCGGCGAGGTCGACTGGGATGCCGCCGCCCTGGAGAACTCCTCCGGAGGAAGCCAGGCGCGTCGCATCGAGCTCGCCCTCAAGCCGGGCGACAAGGTGCTCGTGCAGGTCACCAAGGACCCGATCGGCCATAAGGGCGCCCGCCTGACGAGCCAGGTCTCGCTCCCCGGCCGCTACCTCGTCTATGTGCCCAACGGCTCCATGAACGGGATCAGCCGCAAGCTGCCCGACACCGAGCGAGCCCGCCTGAAGAAGATTCTCAAGGAGGTCCTACCCGAGAACGTGGGCGTCATCGTGCGCACCGCAGCCGAGGGCGCGACCGACGAGCAGCTCACCCTCGACGTCAACCGTCTTACCTCGCAGTGGGCGCGCATCAGCGAGACCATCGAGAAGGCCCAGGCGCCTGCGCTGCTCCACAGCGAACCCGACCTGCTCGTCAAGATCGTCAGGGATGTCTTCAATGAAGACTTCCAGAAGCTCATCATCGAGGGTCAGGATGCCGAGGAGACGATTTCGAGCTACCTCGCCCAGGTCGCACCCGACCTTGTCGACCGCATCGAGCGCTACGAGTCCGAGACTGACTCGTTCGACGCGCACCGCATCTCGGAGCAGATCGAGAAGGCGCTCGACCGCAAGGTCTGGCTCCCGTCCGGCGGCTCGCTCGTCATCGACCGCACCGAGGCGATGACTGTCGTCGACGTCAACACCGGTAAGTTCGTCGGCTCCGGGGGCAACCTCGAGGAGACGGTCACGATGAACAACCTCGAGGCAGCCGAGGAGCTGGTGCGCCAGCTTCGGCTGCGCGACATCGGTGGGATCATCGTGGTCGACTTCATCGATATGGTGCTCGAGTCCAACCGCGACCTCGTGTTGCGCCGACTCGTCGAGTGCCTCAGCCGCGATCGAACCAAGCACCAGGTCGCCGAGGTCACCTCGCTCGGACTCGTGCAGATGACTCGCAAGAAGCTCGGACTCGGTCTGATCGAGTCGTTCAGCGAGAACTGCGAGGTCTGCGCGGGCCGCGGAATCGTCATCCACCACGACCCGGCCACCAAGCACCGCCAGTCGCCGCAGCCGGAGACCGGCCGCCGCGGCCGCAAGGGCGGCAACGGGGGAGGGCCCACCCCTCCGGCGCCGAAGTCCGGCACGGGAACCCACGCGATCACGGAGGACGCCCGCAATGCCCTCGCCAAGATCGCGACGTCGACGATTCTCACCCAGGTCGAGGCTCACGCCAAGGCCGAGACGGCACCGGCCGAGCAGTCGGTGAGCCAGCTGGCCGCGCTCGCGGTCGAGCAGCCCGCCGAGGAGCCCGCCGAGCAGCCCGCCGAGCAGCAGGCGACCGTCGAGGTCGTCGCGCCCGTCCGGGTCGAGGCACCCGCGGAGACAGCCGCGGAGACACCCGCCGAGACTCCGGTCGCGATTTTCGACCTTCCCCTGAAGAGGCAGACGCGCGCGCCTCGCAAGATCTCGACGCATGATGCCGAGCAGATTCTCGACTCGGTGCTCGACGCGCTTCCCGAGCCGCGCCAGGCCGGACAGGGGCGCGTGCGCACCTCCCGCCGCGCATCCTCGGCCGGAACCGTGTCGGCACCGGCCGACGGCTCGCAGAACTAGTCCGCTCGTCGCGGCGGGAGACCGCCGCGACGAGCGTCAACTACGGCGCTTGGTCGTCGGCTTTCGTGGCGCGACCGCGGTGGACGCCGACCTCGTACGAGGTGACGACGATGAGCGTGACGGCGACCAGCGGAAGCACGAACCACAGCATGACAGTGGTGAAACCGTCGGCGGCATCATGCTGGGTCGAAGCGAGCACCAGATACAGCGTGTAGGCGACGTAGAGAAGCACGAACAGCGCACCCTCCCACCGGGCAACGATGAACCCCGTGAAGGCGATCGGCAACAGGGCGACGGCGGTGGCGAGCATGAGCGGCAAGTCGAGGGCGATCGCGGCCGCCGGTACCGGAATACCCTCGCCGAAGATGATCGCGGGCAGGCCCAGCACCAGTCCGATATTGAAGATGTTGCTGCCGACAATGTTGCCGACGGCCATGTCGCGCTCTCCGCGGCGCAGCGCGATGATCGAGGTGGCGAGCTCGGGCAACGAGGTCCCGATCGCGACGACGGTGAGCCCGACGATGAGGCTGCTGACACCAAGGCCGGTCGCGATGCTGACCGCGCCGTCGACGAGGAACTGAGCTCCGAGCACGAGCAGGCCGATACCCGCGGCCAGCAGCAGACCCGCGAGCCACAGTGGAACCGGTGTGCTGTTGAGGGGCATCGTGTCGGGCGATGCGCTCGGGTCGGGGACCTCGCGTCGACCGACGACGATGCTCATGACCGTGTGGATTACAAGACCGGCGAGCAACAGCACGCCGTCAAGAACGCCGATTTGCCCATCGAGGCTCACGACCACGAGCGCGACAGACAACCCCACCATCACTGGAATGTCGAATCGAACGAGCTGCCGTTTGATGAGGAGCGGGCTGATGAGTGCCGAGAGCCCGAGGATGACGAGGATGTTGACGATGTTGCTACCGACCACGTTGCCGACCGCGAGGTCGGGCTCCCCCTCGATGACCGCACCAACCGTCACTGCAAGTTCGGGGGCCGACGTCGCGGCGGAGACGACCACGAGGCCGATGACGAGCGGTGAGATACCCACGCGGGTCGCGATCGTCGAGGCACCCCGCACGAGCGCTTCACCGCCCGCAATGAGCAGCACAAGGCCACCGATGACCATGACGATGTCGAGAGTGTCCACGAGTTCAGACTATTGTCCCGCAACCCGTGGGCCGACTGTGCCGGTGCTCCCTGTCGTGTCGGTCATGGATGCCTGCCGCTCGACTGTGCCGAACGACTGCGCCGAACGGCCACCTCAGGCGGTACCGCGGCGCTCGGCCTGCGAGACGCGCAGGCCGCTCGCACGAAGCCGCAGCACGAGTTCCCGGTTCGACACCGGCACGGCTCCCGCCGCGACAAGTGCGTCGTAGCGCTCGGCGGGCACGTCGTAGTGGTCCCGGTCGAATCCGCGCACTGGTACGCCGCAGCGGACCGCGAAGTCGTGCAACTCCTCGAGCGAGACATCGCTCACCAGGTGCGACCACAGCGTGTGGTGGGCGGGCCACATAGGCTTGTCGATAAGCACTGCCATGGGGTGATTCTAGGCACGGGGGAGCGGAACGGATGGCGCGGGTGACACCGCTCATGCTGCTCGCCGGAGTTCTGATGTGGGTCTGGCCTGGCAACTCACAGCAACACGCTGCCGGTCAGGTTTGACCCTGCATGGTTTGTTCGCGTATTGTTGACCCTTGGCGCGAGCTGGGCTGAGCCCGCATTGCGCGCCGATGATCTTTCTGTCTGATGTGTGTCAGATCCAAATAGTTAGGGTTCCAAGTGGTTTACGCAGTTGTGCGCGCCGGTGGTCGTCAAGAGAAGGTAGAGGTCGGCACGATTGTCGTCCTCGACCGAATCAAGGCCGACAAAGACGGCAACATCGAGCTGGCCCCCGTGCTGCTCGTCGACGGAGACTCGATCACGCATGACGCGTCCGAGCTCGCGAAGGTCACCGTGACCGCCGAGGTCATCACCGACCTCCGCGGCCCGAAGATCGTCATCCAGAAGTTCAAGAACAAGACGGGTTACAAAGTTCGTAAGGGCCACCGCTCCGAACTGACGCGCGTCAAGATCACCAGCATCAACTAACTTTTCCTACAAAGCAGGGGCTGAACACTCATGGCACACAAAAAGGGCGCAAGCTCCACTCGTAACGGTCGCGATTCCAACGCGCAGTACCTCGGCGTCAAGCGCTTTGGCGGCCAGGTCGTCAAGTCGGGCGAGATCATCGTCCGCCAGCGCGGCACGCACTTCCACCCCGGCGTGAACGTCGGCCGGGGCAAGGACGACACGCTGTTCGCTCTCTCGGCCGGCTCGGTCGAGTTCGGCGCCAAGGGTGGCCGCAAGGTCGTCAACATCGTCCAGGCACCAGTCGCGGTCTCCGCGTAGTTTGTGCACGGGCTGCCTCGGCAGCCAGGGTGAGGGCGGGCTTCGGCTCGCTTTCACTCTTTAACCCAACCGGTCCGGTGCGGCCATCCAGGCCCGCGCAACCACAATCGCCGCAGAGCTCGGCACGAAGGGAGCACGATCATGGCTACCTTCGTTGACCAGGTCACGCTGCACCTCAAGGCAGGACACGGCGGAAATGGCTGCGTCTCGGTCAAGCGGGAGAAGTTCAAGCCCCTTGCCGGGCCCGATGGAGGCAATGGCGGCGACGGCGGCGATATCGTCCTCGTCAGCGACACGCAGACGACCACACTGCTCGGCTACCACCGCGCACCGCACCGCACGTCCCCGCACGGCGGCCCCGGTATGGGCGACCACCGCGCCGGCTACCACGGCGAGGGCATGGTCCTCCCCGTTCCCGTCGGCACGGTCGTCAAGTCCACCGACGGCACCGAGCTCATCGACATGGTCGAGCCCGGCATGCGATTCGTCGTCGCCCTCGCGGGGCAGGGAGGACTGGGTAACGCGTCCCTCGCCTCGACCAAGCGCAAGGCCCCCGGTTTCGCCCTGCTCGGTACGCCCGGCTGGGAGGGTGACGTGCTCCTCGAGCTCAAGGTCGTCGCCGACATCGCCTTGGTCGGCTACCCGTCCGCCGGAAAATCGAGCCTTGTGGCGGCCATCTCGGCGGCGAAGCCGAAGATCGCCGACTACCCGTTCACCACACTGCACCCGAACCTCGGCGTCGTCGAGTCCGGCGACACCCGCTATACGGTCGCCGATGTCCCCGGCCTGATCGAGGGCGCGAGCGAAGGCAAGGGCCTGGGGCTCGAGTTCCTCCGTCACGTCGAGCGCTGCACGGCGCTCCTGCACGTGCTGGACTGCGCCACACTCGAACCCGGCCGCGACCCCATCAGCGACCTGGACATCATCCTTGGCGAGCTCGCCGCGTACCCGGTGCCCGAGGGTCAACTGCCGCTGCTCGAGCGTCCCCAGCTCGTCGCGCTCAATAAGATCGACGTACCGGAGGCACGGGAGCTCGCAGAGCTCGTGCGCCCGGAACTGGAGGCACGGGGCTACCGCGTGTTCGACATCTCCACCGTCAGCCACGAGGGCCTGCGACAGCTCTCCTTCGCCCTGGGTGAGCTCGTGGCCCAGGGACGTGCGGCGAAGGCCGCCGAGCCGGAGAAGCCCCGCATCGTTATCCGTCCGCGAGCGGTCAACGAATCGGACTTCGTCATCAAGGTCGAGGGCGGCTCCGGCGGGAACATCTACCGCGTTGTGGGCCAGAAGCCCGAACGTTGGGTCGCGCAGACCGACTTCACGAACGACGAGGCCATCGGGTACCTCGCCGACCGGCTTGCGAAGCTCGGCGTCGAGAATGAGCTGTTCAAATCGGGCGCCGTCGCCGGCTCCACCGTCGTCATCGGCAGGGACGGCCACGTCTTCGACTGGGAGCCGACCCTCAGCTCTACCGCCGAGCTCGCGACGGCCCCTCGCGGCAGCGACCCACGCCTCTCGGAGGCGCAACGCTCGACCCACAGCCGGCGCCGCGAGACCTATCTGGAGCGCATGGACGCCAAGACGGCCGCGAGGGACGAGATGATGCGCGAACGCAACGCCGGGATGTGGAACGACGACGAGGGCTTCGAGGTCGAGCGCCCGGGTGCGCCGGACGACACCGCGGCGAAGGAAGACTGAGCCGCACGATGCCCGAGCAGCTCCCGCTGATCAGCGGTCGGATCGCCTCGCGCGCCGAAATACCCCGCGCGGGGCGCATCGTCGTCAAAGTCGGGTCCTCGTCGATCAGTGGAGCAAATGCGGGACAGATCCGCCCGCTCGTCGACGCGCTCGCGACCGCACACGGGCGCGGATCGGATGTCGTGCTCGTGTCGTCCGGAGCTATCGCGACCGGCATCCCCTACCTGCGGCTCGACTCCCGGCCCACTGACCTTGCGACCCAGCAGGCCGCCGCCGCGGTCGGGCAGAACGTGCTGATCTACCGCTACCAGGACTGCCTCGACCGGTACGAGATCGTGGCCGGGCAGGTGCTGCTCACCGCTGGCGACCTCGAGAACCCCGTGCACCGCAGCAACGCGCAGCGCGCAATGGAACGCCTCCTCGGCCTGCGAATCCTGCCGATTGTCAACGAGAACGACACCGTCGCGACACACGAGATCCGCTTCGGCGACAATGACCGGCTCGCCTCGCTTGTCACCCAGCTCGTGCGCGCCGATCTGCTGCTGCTGCTGTCGGATGTCGACGCGCTGTACACGAGGCCTCCCGGCACGGCCGGCGCCCGGCCGATTCACCATGTCGCGTTCGGGGAGGACCTCGCAGAAGTCGAGTTCGGCGACATCGGGTCCGCCGGCGTGGGAACCGGGGGAGCAGGCACGAAGGTCGCCGCAGCGACCCTCGCGGCAGCATCCGGAACGCCGGTGCTTCTCGCCGCGACGACGCAGGTGGCTGCGGCACTCGAAGGTGCCGACATCGGCACCTGGTTCGACGCGGCCCCGCGGCGCCAGTAACCCACCACACCCCCTGGCTGGGCGCTCGGAAGCCCCTACGATATCGGTATGACTGAGACCGCCGTTTCCACTCGACCCGTCACTGCGCGAACCCTCACCGACAAGCTGGTCGCCGCTCGCGCGGCATCGATCACTCTCGCCACCGCAACCGCGGACCTCAAGAACTCCGCCCTTCGCGCGATTGCGGCCGCCGTTGCCGCAGGGGCCGAGCGCATCATTCCGGCGAACGAACGTGACCTCGAGAACGGCCGGTCGAACGGGCTGAGCGTCGCGCTGCAGGATCGCCTTCGCCTGGACGAGGATCGGCTCGCCGCGCTCGCCTCCGCCGTCGTCGAGATCGCGGCGATCCCCGACCCGGTCGGCGAGTCGGTTCGGGGCCGCACGCTGCCCAACGGCCTCCGTATCAGCGAGGTGCGCGTGCCGTTCGGCGTGGTCGGCGCCATCTATGAGGCGCGGCCCAACGTGACCGTCGACATCGCCTCGCTCGCGCTCAAGAGCGGCAATGCAGCCGTGCTGCGCGGCGGGAGCGCGGCCGAGAACACGAACCGGGTTCTCGTCGAGCTCATTCAGGAGGCGATCGCGTCGGTCGGACTCCCCGCGGACTCCGTGCAGACCATCGACGAGTTCGGCCGGGAGGGTGCCCGGGAGCTCATGCAGGCCAGGGGCCTCGTCGATGTGCTCATCCCGCGGGGGAGCGCGAGTCTCATCAGCACGGTCGTGCTGGAGTCGAAGGTGCCCGTCATCGAGACCGGCGCCGGGGTCGTACACGTGTTCCTCGACGAATCGGCCGACGAGGAGTGGGCGATAGCGATCACCCACAACGCCAAGGTGCAGCGCCCGAGCGTCTGCAACGCGCTCGAGACGATTCTCGTTCACCGGGCATCTGCGGCCCGCCTGCTTCCCGCAGTGCTCGGTCGGCTACGGGCGTCGGGTGTCACCGTGCACGGCGACAGGGCCACCCTCGACCTCTTCGCGGACGCCGAGCTCGCGACCGAGGAGGACTGGAGCACCGAGTACATGTCACTCGACGTGTCGGTGCGTATCGTCGACGACCTCGACTCCGCGATCGAGCACATCCGCCAGTACTCGACCCATCACACCGAATCGATCGTCACTAACGATGTGATCAGTGCCGAACGCTTCCTGGCCGAGGTCGACTCGGCAGTCGTGATGGTCAACGCCTCTACCCGCTTTACCGACGGCGGAGAATTCGGATTCGGCGCCGAAGTTGGCATCTCCACCCAGAAGCTGCATGCGCGCGGCCCGATGGGCCTCAGCGAACTGACCAGCACGAAGTGGATTGTGCGCGGTTCCGGGCACGTTCGCGGCTAGTCGGGACTCTGCCCGGTACGCTGGGATCCGCGGCCCCGTTGCCGCCGAACGGAGAACGCCATGTCAGTCCACGAACTCGTCCTCGCCGTCGAAACGGCCGAGAGCTCGCTTCCCTTCCCCGCCATCGTCTTCGCTGGGATCGCTGCGGTCACCTTCCTCGCCTTGGCGGTTGTCGTCTGGAGCTTCCGTGATGTCGCGAACCGGCACAGCCAGAAGACGGGTGGCCAGGCCGGTCACGGTGCAGACCACCACTAGGCCAGAAGCCTGATGGTCGACTCCACTCCGCTCCGCCCCAGAATCGGGGTCATGGGCGGCACTTTCGACCCCATCCACAACGGCCACCTCTCGGCCGCCAGCGAGGTTCGGCAGCACTTCAACCTCGACGAGGTCGTGTTCGTGCCGACCGGGGTGCCATACCAGAAGACCGGCGTGACGGCGAGCGAGCACCGCTATCTCATGACCGTGATTGCGACGGCATCCAACCCGTCGTTCACCGTCAGCCGCGTCGACATCGACCGGATCGGGCCGACCTACACGATCGACACCCTTCGTGACCTTCGCGCCGAACGGCCGGATGCCGACCTGTTCTTCATCTCCGGCGCCGACGCCGTCGCGCAGATCATCGACTGGAAAGACGCGGTGGAGCTGTTCGAACTCGCGCACTTCGTCGCGGTGACGCGGCCGGGACATCCGCTCTCCGTTTCGGGATTACCCGAGCAGGACGTAAGCTTGCTCGAGGTGCCTGCGCTGGCAATTTCGTCGACCGATTGCCGAAGCCGGGTTAACCGGGGATTCCCAGTGTGGTATTTGGTCCCAGACGGTGTCGTTCAGTACATCTCCAAACACCATTTGTATCGGAGCACGACATGACAGCGTGGCACGACCAGCCGCAGCTCAGCCGACGCCAGCTGCGCGAGAAGTCGCCGACCGACATCGACGACAACGCGGTCGTTGGTGAGAGAGCCGCGGGCGAAAACCCGCCGCGCAGGTCGGCCGGTCGACGCGTGCAATGGGACCCGTCTGCCGAGGCACCCGCTCCCGAGACACCCGCTCCCGAGACGGCCCCTGACGAGGATGTCAGCGCGGGCGCCGACGAGGCCGGCCACGAAAACTCCGACGAGGCCAGCCACGAAAACGCCGCCGGGTATCGCGTGCGCGACTACCGGCCTGACATCCGGCGGGCCACTTTTGCACCACTTACAAGGTCCACCCCGGAGGATTCCTGGAGCCCCCCGGCAGACGCCTCTCGCACGATCGGCGCCGCCGAGCGGGCCGCGCCGCCGACGGAGATCGCCGCCCCTGAGTTTACGATGACGAGGCGCGCCCTACGTGAGCTCCGCCAGCGCGCCGAGGCCGCCGGCCAAGAGTCGCCCAACCTCATGCGCGACGCAAGTGGTGCCCTCGCGCTGACCGGATCGATCGCCGTGATCGACGTGCCCCGCGACGACGAGGAGGCACACGTTTCGGCGGATGCCGAGCACGATGCTGGCGACGATGAGTCTGTTGAGGATCCGTCCGCAGATGAGCTATCTGCAGATGAGCTGTCTGCAGATGAGCTGTCCGCAGTCGAGCAGAACACAGACGCGCCTCAGCACGAACATATTCCCGTCGACGTCATCGTCGCTGAGCAGGCCCTCGCGAGCGTCATCATCGACGACGTGACGATCAGCGAGGCCACGATCATCGAGGCTGAGATCATCGAGGTCGAGACCATCGAGGTCGACGGCGCCGCTGCCACGGATGCCGCAGACCAGCGTGTCGAGCCCGACGATTTCGACGGCGACACCGTGATCTCGGCTCCGACGCAAATAGAGGTGCCGCTCGGCGGGCCTCTCGAGGGGCAGCCGCAGGCCGGTCCGCGGCCGGAGAGACTGAGCCCGTTCGACGCACTCTTCCTTCCGCCATCGCCGGTCGTTCCAGTCGACGATGGGCCGTTACTGTTTGAGCACGATGGTGGCCGCGGCGTCGAGCCGGCACCGGATGCCGCCCCGTACGGCCACTGGTCGACCCAGGCTGCACTCGACGATGCGAGCCAGTCGAGCGAGGCTACGCTCAGTCGCAACGTCGGTCACACCACCGGTGCGATCACGACTCACGCACTCGTCCTGCCCTCGGCGCCGTCATCCATCGACCACCTCCTCAACCCCGTCACCGCGACCGGCGAGATTATGGTGACCGGTTCGGTCGACCTGCCCCGCTCGTTCGGGTCCACTGGCGCGCATCCGGCTCTCTTCGACCACCCCGACGTCGACGCCCTGATCGAAGAGAGCGACAGGGAGGACGCCGCCTCGGAGTCCGCCCCCGTTCGCGCGATCCGCGCCGTCAGCAGCACCTCCTCCACGCGTGGGGTGATCGAGGCTCCCGCACCGCGGAAGTCCCGCTTGCCCCTCATCGCTGGAATCACCGGCGGAAGCGCCCTGCTCGTCGCCGCCGGCGTCGTTGCGGCCGGCTTCATCTTCAACGTCTTCTAACCCCGCGGCAACTGCCGTTTCTCCGATAGGACACTGTGACCGCATCTACCCACTCCATCCAGCTCCTGCAGCGCGCCGCCGCCGCAGCCGACTCCAAGCAGGCTGAGGACCTCGTCGCACTCGACGTGTCTGGTCCGCTGCCGCTGACCGATATTTTCCTGATCGCGACGGGGCGCAACGAGCGTAACGTCGTCGCGATCGCGAGCGAGATCGAAGACCAGCTCATCGAGAGTGGGTCGAAGCCGCTTCGCCGAGAGGGCCGGGCCGAGGGTCGCTGGATCCTCCTCGATTTCGGCGACCTCGTGGTGCACGTCTTCCACGAGGAGGACCGGATGTATTACTCGCTCGAGCGCCTCTGGAAGGACTGCCCCGTAGTCCCGATTGAGCTGCCGACGCAGATCGAGGCACCGGAGGCCGACTGACCTGCGTGCCAGCCATCGAGCTGCCGTCGTGGCGGGGGGAGCCGGGTGACCGCGCCCGCGCCCGACTCGCGATCGACAGGTGGGCTGGGAGCTTGGCGATGGCTCGACTTGTCGAGTCGTTCGGCGGCACAACCGACGACAGGGAGGGGCGGGAGCTCCTCGACTATCTCGGCGAGTTCTCGGCTGCGCACTGGGACTTCCGGCGCGGCCGGGAGCGCAACCTCGCCTCCGATGCGGCGCTGTCGCTCACGCAGAGCGTGCTTGTCGTCGAGGTTGCCCCGCAGCTCGGGCTCACAGGCAGAGAGCGGCCCACGCGTTCGCGTTACGACACAATGCTTCTAACAGGCGGGATGGTGCGCGCAGGCATCGTCAAGCCGCGATTCGCGGCCCAGCTGCTCAAGGACGGGCTCTCTGTGAGCCACATTGCCTTTCTCGGCGGCTTCCGCGCTTTCGGGGGCGATGAACACGCCCTCGCTGGTGAGCTGGGGGTGGACGGCGGCGACGAGGTCGAGGCTATGGTCGCGGGAATGCGACGGGCGTTCGGGTCGCTGGGGGACCCGGTGGTTGAACGACACGTCGCCGACACCCCCCACGCATCCTGGTGCCACTATTCCTGGTCGACCGGTGGCGTGCGACTCAGCGTGGTCGCGGCGCCCTCGTCCGAGCCGAGCGCGCGCCGCGCCAATACCGCCGACACCTTCCGGTTCTGGGCAGCGCACCGCCGCTCCCCGGCCGAGCGGTCGGTGCTCGTTGTCACCACTCCCATCTACGTGCCCTATCAGGCTGCGGGTGCAGTCGAGGCGCTCGGAGTGGAGCAGGGACTCGCTGTTGAGACCGTCGGGGTGGATGCGTCATCGAGCGACCTCGGAGCCCTCACCCAGCAGTTCTTGCCCCAGCATCACCTGCAGGAGGTCCGGTCCGCTATTCGGGCGATGCAGGCACTGCGAGCCCGCGTCACAGGCATCGCGGAGCACACGGGCACCGAGTGAGCGCGACGCGCCCGGGGCCGCGTGGAGTTCGCGCCGCCGCAGAAGTGTAGTAATCTAACGGAGTTGCCTTCTCGGAGCTTCTATCCGGGAGGGCGATGCGGGTCCATGGCGCAGCCCGGTAGCGCACCTGCATGGCATGCAGGGGGTCAGGGGTTCGAATCCCCTTGGATCCACCAAAAGTACTGATCAGACGGCCATTCCAAAACCCGAACAAGGGATTTGGGATGGCCGTTCGACGTTTATTCGACACTTTTAGCTTTCGTACTCACTTATTTCGAATGCCCTCGAGGTGTTCCCGGGCGGGTTCGGAATCGCTTGCACACCTCACAGGTATGACTAGTGAAACTCCCCGACCTCCTGCACCGCGTCACAGCCCACGAACCGATCGCGGCATGACCCCCGACGAACTAACGAACTGCACCACTAGCTCGTGCTCAGCGCTTCCTCATCCGCCGCAACGCTCTTCTGCACGGCGAACTGGGTCCGGTGCAATTCCTCGTACCGCCCGCCGACAGCCAGCAGTTCCTCGTGCGTACCGCGCTCCACGATCGAGCCGTTCTCAACCACGAGGATCAGGTCTGCGCTGCGGATGGTGGAGAGGCGGTGTGCGATCACCATCGCCGTCCGTCCCTCCAGCGCCTCGCTGAGCGCCGCCTGCACGGCGGCTTCAGACGTCGAGTCCAGCGCCGCCGTCGCCTCGTCGAGGATGACGACGCGCGGCTGTGCGAGCAGGAGCCTCGCGATGGTCATCCGCTGGCGCTCGCCTCCGGACAGCCGGTACCCGCGCTCTCCCACCATGGTGTCCAGCTGGTCCGGCAGGGACCGGACCAGCGGCTCGAGCCGCGCACGGCGGATGGCGTCCCACACCTCGTCGTCGGACGCCTCCGGCCTCGCGAGGCGCAGATTGGAGAGGATGGTCTCGTGGAACAGGTGGCCGTCCTGCGTCACCATTCCCAGGGTGTGCCGCATGGAGGCGAAAGTGACATCGCGGACATCCGTCCCCGCGAAGCGCACGGCGCCGCTGTCGACGTCGTACAGGCGTGAGAGGAGCTGCGCGATCGTGGACTTGCCGGCACCGGACGTACCAACGAGGGCAACGGTCTGCCCCGGTTCGATCCTGAAGGACACGCCGTGCAGCACCTCCTCGCCGCCGCGGGTGTCCAGCGTGGAAACCTCCTCGAGAGAGGCGAGGGACACTTTGTCCGCGGACGGGTATGCGAAGCGGACGTCGTCGAACTCGACGGCCACTGGGCCTTCGGGGATGGCGACGGCGTCGGGCTTCTCCTTGATGAGCGGGTCGAGGTCCAGCACCTCGAAGACGCGCTCGAAGCTGACCACCGCGCTCATGATCTCCACCCGTGCGTTTGCGAGGCTGGTGAGCGGCGCGTAGAGGCGGGTGAGGAGGAGCGCCAGGGTGACCACGTCACCGGTATTCAGCTGGCCGGCGAGTGCGAGGAAGCCGCCGAGCCCATACACGAGCGCGAGGGCGAGAGCGGAGACGAGCATCAGTGCCGTGAAGAAGACGAACTGGAGCATCGCGGTCCGGACCCCGATGTCGCGGACGCGGGCGGCGCGGACGCGGAACTCGTCGGCCTCCTCGTCGGGCCGGCCGAACAGCTTGACGAGGGTGGCGCCGGGCGCCGAGAAGCGCTCGGTCATCTGCGTGCTCATAGCGGAATTGTGATCGGCGGCCTCGCGGCGCAGCGCGGCGAGGCGGCTGCCCATGCGGCGCGCGGGTACCAGGAAGATGGGGAGCATGATCACGGCGAGAACCGTCACGAGCCAGGACGTGCTGAGCATGACGATCAGGGTGAGGATCAGCGCCACGAGGTTCGTGACCACGCCGGACAGCGTGCCGCTGAAGGCCTGCTGAGCGCCGATCACATCGTTGTTGAGGCGGCTCACGAGGGCGCCCGTCCGCGTGCGGGTGAAGAAGGCGATCGGCATCTTCTGCACGTGGTTGAAGACGGTGGTGCGGAGGTCCAGGATCACGCCTTCGCCGATCCGCGCCGAGTACCAGCGCGTCACGAGTGACACGGCGGCGTCGGCCACGGCCACGAGGGCGATGACGCCGGCGAGCCAAACGATCGTGGTGACCTCGCCCCGGGCGACGATGACGTCGACAACCTGGCCGGCGAGTACCGGCGTCGCGACCGCGAGGAAAGCTCCCACGGTGGAGAGGGTGATGAAGATCAGCAGCTTGGACCGGTAGGGCACCGCGAACGTCATGATCCGTCGAACGGACTCACGGGAGAAGCCGTGCTTGCCGTCCCTGGCGGTCGAGATCTTGTACAGCGAGCTCCAGGCCGCGCCTTCCATGCTCATTGAGGTTCCTTCCGTGGGCACCAATACAAGCCTAGATGGCGAGTTGCCCGAGCTTTGCGACGCGGCTGCCGAGGTGACGCGCGGTGCGCTGGTCAGCGTCATGGACCGCGTCGGGTCCGCGGTGATTCCCCGAACCGGCGCTACCAACTGCATGGACTGGCTCTACCATCAAGCGCTACTCGCCAACACAACTGAGCGACCGGCGTGTGCTGTCGACACTTCAGCGACATCTAGGGTGGTCGAAATTGCCCGATGGCGATAAAATTCAGGATCGCAACATGGAAGATTGGTTTTGGAAAAGACCGATTGACCAGCACTTCGTCCAAGTGAAGTCGAATCCACGGCTGAAAAGAGGCCAGTCCAAAACCTGCTGAAGACAACAGTGGGTCAGGGGTTCGAATCCCCTTGGATCCACAGAAAAATAGTAGGTCAGGCGGTCATTTCAGAATCCGAGAGGATGATGAAATGGCTGTTTTTCTGTGCTGATCGACAGTTTGGCGTAGAGAACCGCCCGCACTAAGCGTTCACCCACGCCGCCATGATGTAGCGCAGGTCACCCGCGTGCCGGTACTCCAATCGCACTTTCTTCCCATGAACGAACGCCTCCCGCAGCAGCGTCACCAGTTCGAACTCCATGGTTCTATCGGAAGCCTGCGATAGCGGTACAAGAAAGAAGTCCGGATCATCCCGCACCCAGACCAGGAACTGTTCTTGTTCCGCGGGGAAAGTTCCCCCGAGATTGGTTCCCCTGCGTGTCCGGGCCTGCACCCGCACAATCTCGCGATACTCGGGCGTAGTGCGCGCGATCGGGATTGTTTTCGCGACCGGCTGAGCGCGCCACTGCACGGTGCGGGTGGCCCCGGCGATGGGCGATTCGAAGATGCGCCCGGTTGTCGGCAGGTAGCTCCCGGCGCGGTAGTCATAGACCCCCCAGGGATCAATGAAGTGCCAGAACGAAGCGATGGATGCACCGCCATAGGCGAAGGCCGGGCGGGGAACAGCAACGCCGAAATGAAGGTGGAGTGGTTGCTGGGTGGGATCTGTGCGGCCCAGGAACTCGCCTCGCTGCACAGAGTCACCCACTGCATGAGGGCTCGAGCCAAGATCCATGTGCAGGTAGACGGTGCGAAAGGTCCGGCCCTGCCCCGTGGTGTGGGACAGAGTGAGGGCGTCCCCTGCCCTGGCCAAGACTGTACCCTCGGCTGCCGCGCACACGTCGAAGACAGAGACGGGGCTCGTATTGAAGTCGGTGGCCCCGTGGAAAGCGCTCGCGACGTTGCTGTTTCTGAACCATCCCCCGCCGCTTGGCCCCAGTTTGATGTCCTGGTCGTAGAACGGAATCGAGAGATCCATTCTGTCGCCGCTGAGGGGATCGTCGAGGAACCTCTGCAGGTTGGTTCCGGCGATTGGCAGGCCCTGCGGCCGGCTCGGGTTCCCTCCGGCCGGGGTGAACGCGAAGGGCTGAAGTGACGAGACGACCGTGGATCTCGTCGAAGCCGTTAGGTAGTCCTCCGGTGGGACGAGCGTTCCGCCGGCGGGGACCAAGGCAGACGGATCATCGCCGACAGCGTGTGCCAACAGGTTGAGGTTGATGTGAATCACTCCTCCGGGAAATCCCGCCAAGCCCCGCCAGAAGAGGGCCGGTGAGCCATCCGGTGGGAGGTGAACAAAGTAACGGGACATCCGTGTCTCCTTCGCCTTGCAGGCCTGCTTCGACGCAACACTCGCATATCGGCCATCCGTTGGCGATGGGTAACAGGATCACGCCTGAGTCTCGGTTGTTGCCCCTTCCTTTCGGGCCGCCTGAGGAGAACAATCTGTGGCATGGGCGTCTGTGATGTGCTGGATGGCTGGGACGACGCGGGGCCGAACTCCGGCCGAGTCGACGACGTGCGAGGCTTCGTTGACGAACTGCTCGAGTCGTGGGGTTTTGACGCGCCGAACTGGAGCGATCAGATGCCGGCGGGATACGAGGACGCGGCGGGCGTCTACACCCGCAACGACGACACAATTCACCTGAATCCCGACATATTCGAAGGTGACGCTAGCGACGCCCTGAACGTTGCGATCCATGAAGGTCTTCACGCGAGCATGGACCAGATGGGTTGGAACGACCCCGACCTGTTGGAGGAGCTCATGGCGGCAGGCGCCGGTTATCAGGCGCTGGAGGACCTGGTGCAGGGGTGTCAGAACCCCACGGAATCAGGTGCGCCAAGCGACATGCCGAGTTACCCGTGGGTCTCGAGCGAAGGGTAGGGAAACCGGATGCGTCCCTTGACTGCGGCTGAAGAGACCGAGTTTGTCGTCGCTGAGAAACGCCGTCGAGCGTGGCAGCACTTTCAACATCGCGGCGTTGCCCTCGATGCGCAACAGAACTTCCTAGATGCGTTGGTAGCTGCGCTCCCTGTTCCGAAGACGCCTCGGCAGGTCCGGTTCAAGATTGCCCTGCGTGAGCGTCAGGCGCGTGTCGAGCGAGTAAGGCATGGGGTCCCCCCGACCATCAGACTGTTGGCTCGTGCGCATACATCGGCCCTGAACGGTCTTGGAATCACTACGGAATGAGGCGGGTGTCAATGCCGCAGATCGTAACTGGCCCGAATCGGGCTGCGCTCGTCGCGGATGGGATCTACTCGACTGCCGCGGCGGAGATGATCGAGCGTGCTCGCCAGCGGTGTCTGGCGAGCATCTTCATCGCCGACCTTCTCGAGCAGACCCAGCGTGGCCTTGGGGATATTGTCGATGCGCTCGCGAATGCGTCCTGGCGTGGCGTTGACACACGCGTGATCCTCGGTGGTTCTCGGGAGAATTTTCAGATCGCCGCGACAGCCGTGGACGCGGAAGCAATCCTGCGTTCCGAGGGCGTAGCGGTTCGCTGGTTGCTCGCCACCCCCCAAAGGGGCAGCCATGCGAAGTTCCTCGTCTGCGATGAACTCTCACTGCTGGGGTCGCACAACTGGAGCCCAGGGTCGTTCTCAGGGGCACAGGTCCAAGACAGCGTGCTGATCGACTCCGCCGGGATGGCCGGCATCCTCCAGGAGAAGTTCGAAGAGCAATGGCGGCGGGCCGACCGAGGCAACCGTGTATAGGTGGGCGTGGGCCGATCTCGCCACGGACCAGCTGCTGGATGACCTGTCGGCGGGCTGCGGATCTGCACCGATTGCCGACAAGAGCGGCTGTCGAATCATCCTCGCCCGAATGTTCGAGGTTGCGGGCGGTGTTCCGATCTCTGACTACGAGTGGGTCGAAGCGGATCTCGCGGACCGACTGCTCCGCGACGTTGCGACAACGTACCTCGCACGAGTGCTTCCGAGGAACGTATCGCTTTCGGGCGTGGCGTTCGTTGACAGTGCCCTGCCATTTCACTCGGAGGCAGTCGCCGCCCGGGTGGTACCGGTGAATTGGTGCTCGGCGGCCGAACTCGCGGTCCTGCCGATCATCGGTCCCGCCACCGCCAATCGGATCGTAGCTGAGCGGAACGCGAGCGGCTCGTTTCACGATCTCGAGGACCTCTCTCGACGGGTGGGCGGATTTGGGGAGGACTCGGCTCGTCGACTCCGCGGCGTGCTCTCGTTTCACCTGTCGCAATCCGCAGCAAATGAGAACACCGCACAACTGGGCGGCGTCGACGCGTTCGTCGTGGCAGCTCGCGTTGGCGGATTCCTTGCCGGAGGCGACCCTGTCAAAGGCACGCTCGGCGCGCTGTTGGCGGTCGTCGCGAACCACCCTTCACCCGCCCATCGCAATCGTCGCGCGATGCCCGTGTCACGCGGACTCATCGACACGATGGGATGGTTCAACTGCGACTGGACGGCCGCACTCATCGACGAGGATTACCTCTCTGCGCTACCCGACCTGCTGGCGGGAACGACTACGTCGATCGACATGTGCATGTTCCACGTTGCGGTCGGCGTCCACACCCGGCCGATGATCGACGCACTCCTCGCGGCGAGCCAACGCGGCGTTGCCGTCCGCGTCCTCCTCGACCAGGACAGACCAGATGACCCCTATAACTCTACGGTCATCAACACCGCCGCGCGTCGACTGCTAGAGGCCGGGGGAGTGCCAGCCCGATACGACCCGTCTGACCGACTGCTGCACTCAAAGTATCTCGTCCTGGACTCCCACACAGTGGTGATCGGGTCTCACAACTGGTCTGCTGGCTCGTTCGCTTCGTCCGATGACGTGAGCGCAGCCATCCGGAGTGCCTCGCTGGCGAGCAGCCTTACTCAGAGGTTCGAGACGCTCTGGAATGCGGCGCAGCGCTGACTAATCATCGTGCCCGAGTGTCTAGAGACCGAAACTAGCCGAGCCGAGGTTCGAACAGCCGGCGCCTGACCATCACCAATCGCGAATCTCGTCTGACGTGTCGGAGCTGCTAGCTGTCAACCTCCGCCGGAGCTAGAGCCCGAGGGCGGCGATCGCTGCCGCCGCGGCCTCGGCGATCAACCTGTCGTCGTAGTCCGCGTCGACTTGCGCGCGGCTGGACAGCACAGCGATCACGATCGGCGCGGAGTCGGTTGGGTACACGAGAGCGATGTCGTTGCGGGTGCCGTATCCGCCAGCTCCCGACTTGTCGCCCACGATCCAGTCTGCAGGAAGGTTGGCCCGCACGAGGTTGTCTCCTGTTGTTGTGCCGGTCAGCCATCCCGTTACGAGGGCTTTTTGATCGGCGTCGAGGGTGTCGCCGAGCGCGTATTCACGAAGGGTCGAGGCAAGCGCCCGCGGGGTGCTGGTGTCGCGGTCGTCGCCGGGGAGCGCTGACGGCGCTCAGCGAAATTCCCCAGTCTTGCTCATCGAAGCTCCCCAGGTCGCGGGGTTAGGTTAACGGAACTTTGTGACCGTTGTCACGCGGCGGAGTTCGTTGGATTGGGCGGCGTGGTTGCGGAGCCGGTAGGAGCCGCCGTCGAGGGTGACGACGACGGATCGGTCGAGTAGCCGGTCGAGAATCGCGGCGGCGACGGTGGTGTCGCCGAGGATCTCGCCCCAGGCGCCGACGGGCCGGTTCGTGCTGATCACGATCGACGTTTTCAGGTAGCGCTGGTTGATGACTTGGAATAGCGCTGAGGCGGCCTCGGCGGGCAGAGGCAGGTAGCCGAGCTCGTCGATCTATGCGGACATCCGCATAGATCGACCTATGCCGAGCCCGCGATTATGTCGAGGTCGCTGAGGGGTGGTGCTTGGGCGGCCTGATATCGCGCGGCTCTGGGACTGGGACCGCGTGCTGGGGCTCGGCATAGTTGCGTGTTGCGAGGAGTCTCGATGCGGGAGCAGGGTGCTTCCGCGAAGGAGGCGATGGTGATGGCGGGAACGAGAAGGAAGGCTGGTCAGCTGCGGCCGCACGTCGAGGGCTATCAGGCGTGGTTGGCGTGCCAGGGCTACACGACGGGCACGATCAGGAACATGCTTAAGGACCTCGGCCAGGTCGGTTCGTGGCTCTCTGCAGAGGGGCTCACTGCTGAGCATCTGAACGAGGAGCGGATAGGGATGTTCCTGTCGGCCCGGCGAGCTGCTGGGCGGCGGAGGATCCCAGGTCCTCGTGCGATGGTGCCGCTGTTGAGTTACCTGCGCGAGGCGGGCATCGTGGCGCAGCCGACCCCGGTGATGTCGCCGTTGGGAGCACTGCTCAGCTCCTACCGGTCGTGGTTGATCCGGGAGCGAGGCCTGGCACCAGGAACGGTGCTGCGCTACGAGAAGGCTGCGCGGCGTTTCCTGGAGGAGTCCTCGACCGGGGGCGTCTTCGACACGTCGGTGTTGACGGGGGCGGACGTGAATGCGTTCTTGCTGCGGGAATGCGCTCGGGTGTCGGCGGGGTCGGCGAAGGGCCGGGTTGCGGAGCTGCGTTCGATCCTGCGTTTCCTCTACCTGGAGCAGATCACGCCGTTGCAGCTGGGGGCTGCGGTTCCCCCGGTGGGTGGATGGCGTTTGGCGACGCTGCCGCCACCGGCGATGGCGTCAGCGGACGTCCAGTTGCTGCTTGATGGCTGCGACCGCAGCACGGTGGTCGGTGTCCGAGACTTCGCGATGATGATGCTGGTCGCACGGCTCGGGTTACGGTCGATCGAGGTCGCGCGTCTGCAACTGGGCGACGTGGACTGGCGGGCTGGTGAGATCCTGGTCCGTGGGAAGGGCCGCCGGCACGACCGGTTGCCGTTGCCCGCCGAGGTCGGCGAAGCCTTGGTGGCCTATTTGTTGTCCGGTCGGAACCCTGCCGATGCCGTCCATGTGTTCTTGACCTGCCGTGCCCCGTGCCGTCCGGTTCGCGCCGACCTGGTCGGTGATGTTGTCGAGCGGGCCTGCAAGCGTGCTGGCCTGCCGAGGGTTGGGCCACACCGGCTCCGGCACGCGCTGGCCGGTGAGATGCTCCGCAAGGGGGCCGGTCTGATTGCGATCAGCCAGGTCCTGCGCCACCAGGATCTCGCCACAACTGCCCTCTACGCCAAGGTCGACCTGCGCACTCTGCGTGAGGTCGCGCAGCCGTGGCCGGGAGTCCGGCGGTGAGCACGCTGGAGCAGGACCTCGCGGACTACCTTCAGTTGCGCCTGTCGCTGGGGCATGAACTGGCCGAAGCCCGATGGTTGCTGCCGGGATTCGTCTCCTACCTCAACGCCCACAGATCCTCGACGGTGACGATCGAGGCGGCGCTGGCCTGGGCGCAGCAATCGGCGACGGGGCGAGGGGCGTCGGTCGGGCCGCGGCGGATGACCGCCGCCCGGGGCTTCGCCCGCTACCTGGCTGGCATCCACCCGAACACCGAGATTCCACCGCTGGGACTGATGCCGCACCGGCAGCGCTGGCGCCCACCGTTCATCTACTCCCCAGCTGACATCGACGCCGTGATCAGCCAGGCCCGCTGCTCCATCGTCTCGCCGCTGCGGGCGGCGACCTACGACACTCTGATCGGTTTGCTGGCTGTCAGCGGGCTCCGGATCGGGGAGGCGATCAAACTCGACCGCAGCGATATCGACTGGGCCGAGGGCGTGCTGCTGATCCGAGAGTCGAAGTTCGGGAAATCCCGCCTGATTCCCCTGCACGGCAGTGTCATGGAGGCGCTGGCTACGCACGCCGCGCTTCGCGACGAGCTGCAACCGCGGCCGAAGGAGCCGAGCTTCTTCGTGTCCCTGACCCGTAATCGGCTGAGCTACGCCGTCGTCAGCCAGACGTTCCGGCGGCTGGTCGTCGACGCGGGCGTCGGGATCGGGTCATCGTCGCCGCCCAGGCTGCACGACCTGCGTCACACGTTCGCGGTCCGCACCCTGTTGGGCTGGTATCGCGACGGTCAGGACATCCAAGCCAAGCTCCCCGCGCTCTCCACCTATCTCGGCCATCGCGAACCCGCATCCACCTATTGGTATCTGTCGGCCACCCCGGAACTGCTCGCCCTGGCCGCGGCACGTCAGGACACCGCGTGGTCGGCGGCCCGCTCATGACCCTGATCGCGCCGACGCTGCAGATGTTCTTCACCGACAGGCTCGCCCAGCAGCGCCAGGCCAGCCCGCGCACGATCGCCGCCTACCGCGACACGATGCGATTGTTGCTCGGATTCGTGCACCGCACGACCGGCAGACCGCCCTCGCAACTGGACTGGGACGACCTGGACGCGGCGATGATCAGCAAGTTCCTCAACCACCTCGAGGACGAGCGGAATAACAGCGTCCGGACCCGCAATGTTCGCCTGACCGCGATCCGGTCGCTGTTCTCCTACGCCGCCTTGCGTCACCCCGAACACGCACTCCTGATCCAGCGAGTCCTGGCCATCCCGCCGAAACGGTTCGACAAACGCGTCGTGACCTACCTGACCCCGCCCGAGATCGACGCTCTCATCGCCGCACCCGACCAGACCCGATGGGAAGGACGACGAGACAGAGCGCTGATGCTCTTGGCCATCCAGACCGGCCTGCGCGTCTCCGAACTGACCAGCCTGAACTGCGCCGATGTAACCCTCGGCGTCGGCGCGAACGTCCGCTGCGAAGGCAAAGGTCGCAAGCAACGCGCCGTCCCACTCACCCGACCCGTCGAGGCGCTCCTGCGACCGTGGCTCGCCGAGCGGGCCGGAGCGCCGGACCAACCGTTGTTCCCGACCCGGACCGGGCGGCGACTCAGCCGCGATGCCGTCGCACTCAGGATCAGCACGCACGCCGCGACCGCCGCACTGCGATGCCCCACGCTACGGGGCAAGCAGATCCACCCGCACGTGCTCCGACACACCTGCGCGATGACCCTGCTGCAGGCCGGCGTCGATACCTCCGTGATTGCGCTCTGGCTCGGCCACGCCGGAGTCCGATCCACCGACGCCTACCTCCACGCCGACATCAGCATCAAGGAGAAAGCCCTCGCTCTTACCACGCCCGCATCTGCGCGACCCGGCCGCTACCGTCCCACAGACAAGGTGCTCGCCTTCCTCGAGAGCCTGTAA

Protein sequences of DBSCAN-SWA_2

>NZ_CP017146|1857011:1932211|1907607_1908318_-|WP_161887451.1|DBSCAN-SWA
MPGKPSLASSERGSDDYPKLSHAPAISAAFTPCDNPRVTSTARTSRPIPLAIFLVFAGVVGFVAAFALTLEKFAGLVNPGEAAGCDFSVLVQCTKNLESAQGSTFGFPNPLIGLAGFTAVIAVGVGVLAGARFARWFWALFNLGLLGALAFVAYLISTSIYYLGTLCPWCMVVWSVTIPAFIAVTLYNVKAGVIPLPGRLRRALGGAYAWTPFLTLLCYIVVALLAQLRLDVIRYL
>NZ_CP017146|1857011:1932211|1874066_1874735_+|WP_161886112.1|protease|DBSCAN-SWA
MDISSYGGSAGPMAESRYILPTFEERTAYGYKRQDPYAKLFEDRIVFLGVQVDDASADDVMAQLLVLESQDPDRDIVMYINSPGGSFTAMTAIYDTMQYIRPQIQTVCLGQAASAAAVLLAAGTPGKRLALPNARILIHQPSTGDAGRGQASDIEIQAQEILRMRTWLEATLSFHSNRSPEQVNKDIDRDKILGADAALEYGLIDQVLTSRKNVQIPAALSK
>NZ_CP017146|1857011:1932211|1915440_1916259_+|WP_161886141.1|DBSCAN-SWA
MPEQLPLISGRIASRAEIPRAGRIVVKVGSSSISGANAGQIRPLVDALATAHGRGSDVVLVSSGAIATGIPYLRLDSRPTDLATQQAAAAVGQNVLIYRYQDCLDRYEIVAGQVLLTAGDLENPVHRSNAQRAMERLLGLRILPIVNENDTVATHEIRFGDNDRLASLVTQLVRADLLLLLSDVDALYTRPPGTAGARPIHHVAFGEDLAEVEFGDIGSAGVGTGGAGTKVAAATLAAASGTPVLLAATTQVAAALEGADIGTWFDAAPRRQ
>NZ_CP017146|1857011:1932211|1908586_1911349_+|WP_161886135.1|DBSCAN-SWA
MVEYNENNDETPRKRKGLFGSRRVRSADMVPAEQSAAPVPDAVEPREQPAAEQPVAEQPAAEQPAAEQPVAEQPALEQAVAQRASRSRRASSASAAAAPTENPTEEAAPAEPVTARRTRQSAAKSTATRSTAASRATKAKAETPAPDEAPAADGTPAADDTAEQSTEQSAEQPTTPEAPAAPARPSTSLLFQAPELPAYAPRQQSRDNRGGNDRDNRGESRDDGRDEDEQTTVRRRSRRRSGEEDRDTGSSNPRNTVVKVRTPRPQPEPITEPQRIKGSTRLEAKKQRRRDGRDAGRRRPVITEAEFLARRESVDRVMVVRAKFGRIQIGVLEDGVLSEHYVAKAQEASLIGNVYLGRVQNVLPSMEAAFVDIGRGRNAVLYSGEVDWDAAALENSSGGSQARRIELALKPGDKVLVQVTKDPIGHKGARLTSQVSLPGRYLVYVPNGSMNGISRKLPDTERARLKKILKEVLPENVGVIVRTAAEGATDEQLTLDVNRLTSQWARISETIEKAQAPALLHSEPDLLVKIVRDVFNEDFQKLIIEGQDAEETISSYLAQVAPDLVDRIERYESETDSFDAHRISEQIEKALDRKVWLPSGGSLVIDRTEAMTVVDVNTGKFVGSGGNLEETVTMNNLEAAEELVRQLRLRDIGGIIVVDFIDMVLESNRDLVLRRLVECLSRDRTKHQVAEVTSLGLVQMTRKKLGLGLIESFSENCEVCAGRGIVIHHDPATKHRQSPQPETGRRGRKGGNGGGPTPPAPKSGTGTHAITEDARNALAKIATSTILTQVEAHAKAETAPAEQSVSQLAALAVEQPAEEPAEQPAEQQATVEVVAPVRVEAPAETAAETPAETPVAIFDLPLKRQTRAPRKISTHDAEQILDSVLDALPEPRQAGQGRVRTSRRASSAGTVSAPADGSQN
>NZ_CP017146|1857011:1932211|1889355_1890171_-|WP_161886123.1|DBSCAN-SWA
MSDDTPTGRFDPNAPDPTTPASDSDDTPPDSGDARTRRFDHAGDDAPTEKFTASGAPAGDETPTERFAGPSGRSETQRLPPPQGPQGPRPVLAERTATTSRGPMIAFIVIAAVLLLALALLLYNLATRDPETVPAPAASPEASEVPTPTPTPSEPESEPVPDPTQSEEPVDDQGAAFTTFSPESGTPVSCPDDTSSIPLTFEWTSTGAEAAWIGVGTNDAKAEPFAEVDTSGVFTDISYQCANPSEIYTVTLDDGAGTLTHATVTLERALG
>NZ_CP017146|1857011:1932211|1913467_1913737_+|WP_161886139.1|DBSCAN-SWA
MAHKKGASSTRNGRDSNAQYLGVKRFGGQVVKSGEIIVRQRGTHFHPGVNVGRGKDDTLFALSAGSVEFGAKGGRKVVNIVQAPVAVSA
>NZ_CP017146|1857011:1932211|1894510_1895356_+|WP_161886126.1|DBSCAN-SWA
MTVTLGRTRLRPPRAGLAGAIAASAFLLVLVVAAAAPALFTSADPIQTQVLQALRAPSVEHPFGTDQTGRDVFARVVYGARYSLAIGVLATTIAMTAGLLVGTLAGLAPRLVDSAISRVIEVLMSFPEFLLALLVIAILGPGPVSLVIAISLASVPVYARVARVQTFTVRRSGYVRAAVILGVPRWRNVLRHVVPNTLGPLLVMATIGFGTAIASAAGLSFLGLGAQPPTPEWGLILSEGRNFLGTAWWIAVFPGLVVTVTVISASVLGRYLRARGEGRAA
>NZ_CP017146|1857011:1932211|1931221_1932211_+|WP_161886154.1|integrase|DBSCAN-SWA
MTLIAPTLQMFFTDRLAQQRQASPRTIAAYRDTMRLLLGFVHRTTGRPPSQLDWDDLDAAMISKFLNHLEDERNNSVRTRNVRLTAIRSLFSYAALRHPEHALLIQRVLAIPPKRFDKRVVTYLTPPEIDALIAAPDQTRWEGRRDRALMLLAIQTGLRVSELTSLNCADVTLGVGANVRCEGKGRKQRAVPLTRPVEALLRPWLAERAGAPDQPLFPTRTGRRLSRDAVALRISTHAATAALRCPTLRGKQIHPHVLRHTCAMTLLQAGVDTSVIALWLGHAGVRSTDAYLHADISIKEKALALTTPASARPGRYRPTDKVLAFLESL
>NZ_CP017146|1857011:1932211|1879363_1879768_+|WP_161886116.1|DBSCAN-SWA
MISRREAALRLDIPIEMAQRHGLGTWVSEEELAAIESEPPAWLVQSRANRTGKKPVWVRLECDVCGFGESVRPKKWWPQFTFISCDHHSIHDLPEPAGGHVRREFDGIGSRFIGILDDAPDAPEGPDAPDQPAS
>NZ_CP017146|1857011:1932211|1883220_1883469_-|WP_161886119.1|DBSCAN-SWA
MQLGTRWPIGGEVPDRVPAAVVSAVNDIESELTGTDTSQWRWTLTWLEGRPIVDLDDGTVIRYDDVSDVALVAHRDDPEDDD
>NZ_CP017146|1857011:1932211|1917651_1917846_+|WP_161886143.1|DBSCAN-SWA
MSVHELVLAVETAESSLPFPAIVFAGIAAVTFLALAVVVWSFRDVANRHSQKTGGQAGHGADHH
>NZ_CP017146|1857011:1932211|1916307_1917591_+|WP_161886142.1|DBSCAN-SWA
MTETAVSTRPVTARTLTDKLVAARAASITLATATADLKNSALRAIAAAVAAGAERIIPANERDLENGRSNGLSVALQDRLRLDEDRLAALASAVVEIAAIPDPVGESVRGRTLPNGLRISEVRVPFGVVGAIYEARPNVTVDIASLALKSGNAAVLRGGSAAENTNRVLVELIQEAIASVGLPADSVQTIDEFGREGARELMQARGLVDVLIPRGSASLISTVVLESKVPVIETGAGVVHVFLDESADEEWAIAITHNAKVQRPSVCNALETILVHRASAARLLPAVLGRLRASGVTVHGDRATLDLFADAELATEEDWSTEYMSLDVSVRIVDDLDSAIEHIRQYSTHHTESIVTNDVISAERFLAEVDSAVVMVNASTRFTDGGEFGFGAEVGISTQKLHARGPMGLSELTSTKWIVRGSGHVRG
>NZ_CP017146|1857011:1932211|1869091_1869412_+|WP_161886108.1|DBSCAN-SWA
MNETTESSRKRPETHGSSEAGRYLRFIDWLNRSLEGPLGPPPSGPFDEVVQQVGAATCPVCNRPMSEHRIDHTVSNAVLHCPVGHERPAEHQEPLNELGMPKRPHD
>NZ_CP017146|1857011:1932211|1872094_1873303_+|WP_161886111.1|DBSCAN-SWA
MTSRPDKHDPLTLRLLTQAVHAGNAIDPGTGAVRTPLVLANSYALPDDPSEISWSGTDIPLYTRNSGVNQLALQQKLAVLDNGEDAVALASGVAALHAVFFTFLKSGDHVVVADVVYEATHRLFTELLPEKYGIEATLVDTTDLAAVRAAIRPTTRLVHVETPANPTTRITDIHELALIAHKAGALLSVDSTFASPLLLRPLDQGADLVVHSLTKYINGHGDAMGGAVIGSRELIQQIKSDAMIDVGGVISPFNAWLIMRGSITLPLRIRQHCVNARAVADVLDADDRVAFVAYPGLASHPQHELARRTMPNGFGGMLAFAVVGDSATQDRFVSNLRVITSAVSLGHDESLIVHVGSTAPRAAHWPEEFRTNGHLRFSVGIEDPADLIADLRAALDATFAPD
>NZ_CP017146|1857011:1932211|1864917_1865091_-|WP_161886104.1|DBSCAN-SWA
MPASENSPLAPSGWYRDPLGLPQLRWWNGMMWTNQIEEPRAEIQVSSAYKVELVSSP
>NZ_CP017146|1857011:1932211|1891905_1893549_+|WP_161886125.1|DBSCAN-SWA
MPARYPRSLRTAGAVAALAIAGLLAGCTAASSEGDQQSLTYAIEGANLSAGHMDPHSSQLDVSALVQRAVFDSLVAQDLDGSFQPWLAEKWEISEDQLHYEFTLREDVTFHDGEPFNADAVVANFEHVTAPETASAQAASMIGYSADGGSYLGAEAVDEFTVRFDFSTPYAPFLQAVSTSQLGFYSPAVLDEKADELKTGGPGISVGTGPFVLSEYTPDQEIVYTANPDYDWAPESAEHSGASDLDELVVRILPEPSVRTGALASGEVQVAGNVTPSTVGSLGDDITVNSVELPGLPYSLYLNQNNGVFADVKVRQAFQLGFDPQDAVDGIFFGQYPRAWSILGPTTPDSYDSSLEQRPAVDVDRANELLDAAGWTERDAEGYRTKDGERLSARWIAYTPIPDDRASLADVIQSDLKGIGFAIVREALEPAAYNEQYGPKTFDITDWGFSGVDADLLRSHLHTDGFQNASGLSDPAIDTLLEDAVATSDPTERAALYTELQQWNAENVAIVPLYVPSMITAFSDSVTGLTFDLYGRPLFYGVQVQGS
>NZ_CP017146|1857011:1932211|1924314_1925151_-|WP_161886149.1|DBSCAN-SWA
MDLSIPFYDQDIKLGPSGGGWFRNSNVASAFHGATDFNTSPVSVFDVCAAAEGTVLARAGDALTLSHTTGQGRTFRTVYLHMDLGSSPHAVGDSVQRGEFLGRTDPTQQPLHLHFGVAVPRPAFAYGGASIASFWHFIDPWGVYDYRAGSYLPTTGRIFESPIAGATRTVQWRAQPVAKTIPIARTTPEYREIVRVQARTRRGTNLGGTFPAEQEQFLVWVRDDPDFFLVPLSQASDRTMEFELVTLLREAFVHGKKVRLEYRHAGDLRYIMAAWVNA
>NZ_CP017146|1857011:1932211|1884173_1886777_-|WP_161886121.1|tRNA|DBSCAN-SWA
MSAAIPEKPALEGLESKWGASWESSGTYMFDRAAALAAGRDGVYSIDTPPPTASGSLHIGHVFSYTHMDLAARYQRMRGKHIFYPMGWDDNGLPTERRVQNYYGVRCDPTLGYAAGFEPPLKGGEGASSKAADQLPISRRNFIELCERLTVEDEKQFEDVWRALGLSVDWTQTYRTIGDPAQRVAQRAFLRNLARGEAYQAEAPTLWDITFRTAVAQAELEDKEQPAAYHRIGFAKPDGEPLFIETTRPELLPACVALVAHPDDERYQHLFGTTVTTPLFGVEVPVLAHHLAQKDKGSGIAMICTFGDVTDVVWWRELDLPNRTIIGADGRIIADAPDAIVSDAAIEAFAELAGKTVFSAKKRVVELLRESGDLVGDPKPIIHSVKFFEKGDKPLEIISTLQWYISNGARDPELRTKLISRGKEINFTPEHMRVRYENWVGGLTGDWLISRQRFFGVPIPVWYELDADGNKGAVIVPSESSLPIDPSSDTAPGYDERQRGEPGGFAGEIDIMDTWATSSLTPQIAGGWESDPELFDLVFPYSLRSQGQDIIRTWLFSTVLRAELEHGVVPWKNAGISGFIVDPDRKKMSKSKGNVVTPAAMLETHGSDAVRYWAASSRLGTDAAFDPQNPKQIKIGRRLAIKVLNAAKFVYSFPTPAASPVEAVETTVTNPLDLDLLAELGRVVETATIALDGYDHAKALESTEQLFWTFCDDYLELVKERAYGAATPAEQASAVTTLRTALDVFLRLFAPFIPFATEEVWSWTHEGSVHAAQWPTPTIDRSPTGLLGVVGTALIGIRRAKTDAKASQKTEVLSAIVHAPTERLALLRLAAEDLKAVGRIAELHFVEGPEITVTDVVLAEALVEATD
>NZ_CP017146|1857011:1932211|1874827_1875544_-|WP_161886113.1|DBSCAN-SWA
MTYSPPSRGFRRPNTALPALLGCAVLLGSIFAVAGPAMAHNSLVASTPEAGSILTTLPPEFSITTNEDMLDTGDSVSAFLLRVVGEDGLYYGDGCVSVDGPTMSADAALGPAGEYTLAWRAASIDSHPIDGQFTFEWDPADDAEISAGSATPPECGVEPTPVEEPAEGQASGTDSDDAAGADADADADADADASESPSADPEQTSSTVPNSLLIAGIGAVAAAAIGGTVFAVRRRRNA
>NZ_CP017146|1857011:1932211|1900152_1901460_-|WP_161886130.1|DBSCAN-SWA
MSSTSSVSVKNLYKVFGRRPKDAVKKLQDGVSRSDLGAHETAAVIDASFEVKKGEIFVVMGLSGSGKSTLIRTLNGLLDPTSGSVTVNGIDISDVSPAKLREVRQKNVSMVFQHFALFPHRTVLDNAAYGLEVQGIPRAERLERALKIVNIVGLDGWADKYPSELSGGMQQRVGLARALATETDIMLMDEAFSALDPLIRREMQEQLLELQAELGKTIIFITHDLNEAMFLGDRIAVMRDGRIVQIGTPEDILTDPANDYVAQFVQDVDRARVLTAATVMEPARAVVPLTAGPRGALRVMRDLQAGAAFVLGRDLTLLGVVTDRHVMRQVKSNETDLSLVINQEHASVPADAALVDLFELAVESPLPIAVIDDKRRLLGVIPRITLLAALGNVPTNTTPINIIEPVSIIPDAELDAMLASPEPTPAAASTEGTLA
>NZ_CP017146|1857011:1932211|1905348_1906785_+|WP_161886132.1|DBSCAN-SWA
MKQSSSSCRCTEGVSMSKNRDAEDPELSNDALFQAQADRVYGELLARIGEANPQPRLGPTRKVLELLGDPQRTYPIIHITGTNGKTSTSRITESILRAYGLRTGLMISPHLVRVNERIVVDGEPISNEAFVANWDDIAPYIAMVDNELIEAGELALTYFEALTALAFACFADAPVDVAVIEVGMGGEWDSTNVGDGQVAVFTPISLDHTQRLGNTVLEIAKTKSGIIKPLASVVTAVQQPDALAVLRHAAELTESTVVAQGEEFALIENSVAVGGQVISVKGLAGTYRDLFLPLFGDHQAQNAAVAIAAVESFLGGGSQMLVGDVLAEGIGTATSPGRLQVVGVEPSVLVDAAHNPDGAGALASAVATYFTFDEVCVVVAALDEKDAAGIIGALTPIASRFHVTRSSSARAIDEDELGEIVREVAGPDSYEVFAGAEEALASAREWARGAAKRAVLVTGSVTLVGDAIAIADREGWKR
>NZ_CP017146|1857011:1932211|1926993_1928064_+|WP_161886152.1|DBSCAN-SWA
MFEVAGGVPISDYEWVEADLADRLLRDVATTYLARVLPRNVSLSGVAFVDSALPFHSEAVAARVVPVNWCSAAELAVLPIIGPATANRIVAERNASGSFHDLEDLSRRVGGFGEDSARRLRGVLSFHLSQSAANENTAQLGGVDAFVVAARVGGFLAGGDPVKGTLGALLAVVANHPSPAHRNRRAMPVSRGLIDTMGWFNCDWTAALIDEDYLSALPDLLAGTTTSIDMCMFHVAVGVHTRPMIDALLAASQRGVAVRVLLDQDRPDDPYNSTVINTAARRLLEAGGVPARYDPSDRLLHSKYLVLDSHTVVIGSHNWSAGSFASSDDVSAAIRSASLASSLTQRFETLWNAAQR
>NZ_CP017146|1857011:1932211|1878301_1879315_+|WP_161886115.1|DBSCAN-SWA
MTSFSAIPLSVLDLATVRAGMTNAEALAQTITTAKAADELGYRRFWVAEHHGMAAVASSAPAVLIGAIAAATTRIRVGSGGVMLPNHSSLVIAEQFGTLVALHGDRIDLGLGRAPGTDGLTARMLRRNVQNETADDFPQQVVELLALFGIVPPLENGVGATVVAVPGAGDAPLMWLLGSSGFSAQLAGIMGLPFVFAHHFAGTAETPRAFELYRERFTPSAVLEKPLAMVSVATVVADDAKEASRLALPHNLWAVRLRQGGRPGAVPTLAEAEAHPWTEGERAFAAERNAQQAVGSREHVRSRVSALVEATGANEVILVPQGPDLESRLRTLTELAA
>NZ_CP017146|1857011:1932211|1911389_1912496_-|WP_161886136.1|DBSCAN-SWA
MDTLDIVMVIGGLVLLIAGGEALVRGASTIATRVGISPLVIGLVVVSAATSAPELAVTVGAVIEGEPDLAVGNVVGSNIVNILVILGLSALISPLLIKRQLVRFDIPVMVGLSVALVVVSLDGQIGVLDGVLLLAGLVIHTVMSIVVGRREVPDPSASPDTMPLNSTPVPLWLAGLLLAAGIGLLVLGAQFLVDGAVSIATGLGVSSLIVGLTVVAIGTSLPELATSIIALRRGERDMAVGNIVGSNIFNIGLVLGLPAIIFGEGIPVPAAAIALDLPLMLATAVALLPIAFTGFIVARWEGALFVLLYVAYTLYLVLASTQHDAADGFTTVMLWFVLPLVAVTLIVVTSYEVGVHRGRATKADDQAP
>NZ_CP017146|1857011:1932211|1912610_1912886_-|WP_161886137.1|DBSCAN-SWA
MAVLIDKPMWPAHHTLWSHLVSDVSLEELHDFAVRCGVPVRGFDRDHYDVPAERYDALVAAGAVPVSNRELVLRLRASGLRVSQAERRGTA
>NZ_CP017146|1857011:1932211|1896914_1898183_+|WP_161886128.1|DBSCAN-SWA
MTSRPSLARKLGLADAVFIGLGSMIGAGVFAAFTPAAHAAGNGLLIGLVVAAVVAVCNALASAQLAAVYPESGGTYVYGRRVLSPWWGFLAGWSFVIGKTASCAAMALTFAFYAAPAGWERPVAVAAVVGLAAVNYRGVTRTAALTRVIVVVVLLALAVAVAAGGSIIGGPAGFAEATDPGGLLAGGGYGILQSAGLLFFAFAGYARIATMGEEVRDPERTIPRAIVIALAITVVVYGIVAVTLLGVLGPDGVASSVAPLADTVRASGWDWAAPLVRLGAAAASLGALLALFAGIGRTTLAMAREGDLPSWLASVHPKFSVPHRAEVVLALVVSVLVLTVDLRGAIGFSSFGVLLYYFVANVAAFHQPAAERRYPRALQVLGAVACVILVATLPPVGIAVGVGVLLVGAAYRIASMRGTART
>NZ_CP017146|1857011:1932211|1898269_1899178_-|WP_161886129.1|DBSCAN-SWA
MNKSIKTAFAFAGAAGLIALAGCSTDADAGSDASGLENGDAQDVTIAVFNGWPEGEAVSHLWAAVLEEEGYNVELEYADVAAGFVGLSSGDYDLNMDVWLPGTHAEYLEEYGDDIVDVGTWNTDATLSVAVNEDAPIDSLAELADNGDLFGNRIIGIEPGAGLTKITQENVMPTYNLDAFELTTSSTAAMLAELTAATDAGENIAVTLWHPHWAYDAFPIKDLADPEGALGDAEGLHTFSRTGFGEDYPTLNGWLEDFEMETAPLDSLQNEMFGSGADASEYEEIVQTWIGENQEWVDGLTS
>NZ_CP017146|1857011:1932211|1918457_1920062_+|WP_161886145.1|DBSCAN-SWA
MTAWHDQPQLSRRQLREKSPTDIDDNAVVGERAAGENPPRRSAGRRVQWDPSAEAPAPETPAPETAPDEDVSAGADEAGHENSDEASHENAAGYRVRDYRPDIRRATFAPLTRSTPEDSWSPPADASRTIGAAERAAPPTEIAAPEFTMTRRALRELRQRAEAAGQESPNLMRDASGALALTGSIAVIDVPRDDEEAHVSADAEHDAGDDESVEDPSADELSADELSADELSAVEQNTDAPQHEHIPVDVIVAEQALASVIIDDVTISEATIIEAEIIEVETIEVDGAAATDAADQRVEPDDFDGDTVISAPTQIEVPLGGPLEGQPQAGPRPERLSPFDALFLPPSPVVPVDDGPLLFEHDGGRGVEPAPDAAPYGHWSTQAALDDASQSSEATLSRNVGHTTGAITTHALVLPSAPSSIDHLLNPVTATGEIMVTGSVDLPRSFGSTGAHPALFDHPDVDALIEESDREDAASESAPVRAIRAVSSTSSTRGVIEAPAPRKSRLPLIAGITGGSALLVAAGVVAAGFIFNVF
>NZ_CP017146|1857011:1932211|1883523_1884174_-|WP_161886120.1|DBSCAN-SWA
MSVRVGAGLRIVVALVSALALAGCATTAPPGGEPDPASSSTDPPSSDPPSSDPPSSDPPSTAEPVLRRPLVPVTARELLEYCPAADAQHFDGDIVAVLNIYVCSASDILSTNGGGEGEDGRDSGNGALPDVQRASRVIAGGDDLLAAYSAPNEPATTGACIQLAADPLIVWVGTSAGITPVYAPVDECGFPTRAATEAFDGVELETILEIRSDPAD
>NZ_CP017146|1857011:1932211|1868108_1869065_+|WP_161886107.1|DBSCAN-SWA
MNRSPLSAGLMFALVAAASFGVSGALIKPLLEGGWSPAAAVTVRALTGGLILAPFAVIALRGRWGSVWLGRWRILGMATVGVAGTQLFYFAAVQRIPVGTAILIEYMAPLLLVAVAWAMTRRRPAVVVLAGSVAAFAGLLLIVSPSGSGALDPLGIASAVTAMVCCAGYFVIAARPSAGLPPVALASAGLLIAPVLLALAGLLGMVPFTASVDEVTLLGRATPWWVPMLVVGVVSTAVAYATSITAGGMLGSRLASFVGLLEVAAAGLWAWMLLGESLTMLQLFGGGLILVGIGFVHSDRSVPVAPVGEKTPAFGPSR
>NZ_CP017146|1857011:1932211|1879764_1881810_-|WP_161886117.1|DBSCAN-SWA
MSHPNPFLAPSTLPHGLPPFAEIAPEHFRPAFDAGFTEQLAEVAAISADPDAPTVENTLLPLERSGQLLERVASVFYNKSSADNDDFVSALEEEIAPRMAAHSDAIRLDPALYARVAAIHAGIHAGTDAGTAPLDPETRYLVDRHFAELTLAGAGLGETEKQALRDYNRELSTLTTRFEKNLLADSNDLAVVIDDVAELDGLSRDDISAAATAAAERGLDGKYLITLVLPTGHPYLSQLIRRDVRQRIMEASRSRGIRGGDHDTRALVLEITRIRAERAALLGFASHAAYVTADSTAQSPARVSELLGRLAPPAARNARAEQAELEALAGHQIEAWDWDFYSEKVRAAKYDVDTASMRPYFEAERVLHDGIFFAAEKLYGVTFTERADLVGYHPEVRVFEVRNEGGEEIGLYLLDLYTRDSKRGGAWMNALISQSRLLGHPTVVVNNLNVPGPAAGTPTLLTYDLVNTFFHEFGHALHGLFARVTYPMFSGTNVYRDFVEFPSQVNEMWMLWPEVLANFAVHYETGERMPEELVAKLQASSAFNEGFATSEYLAAALLDQAWHAIGPDATVTDVAAFERDALAAAGLDNPAVPTRYSSTYFAHTFSGGYAAAYYSYIWSEVLDADTVDWFTENGGLTRANGDRFRDRLLGVGGSKDPLEAYRDFRGRDAVIEPLLKRRGLS
>NZ_CP017146|1857011:1932211|1930292_1931225_+|WP_161886153.1|integrase|DBSCAN-SWA
MSTLEQDLADYLQLRLSLGHELAEARWLLPGFVSYLNAHRSSTVTIEAALAWAQQSATGRGASVGPRRMTAARGFARYLAGIHPNTEIPPLGLMPHRQRWRPPFIYSPADIDAVISQARCSIVSPLRAATYDTLIGLLAVSGLRIGEAIKLDRSDIDWAEGVLLIRESKFGKSRLIPLHGSVMEALATHAALRDELQPRPKEPSFFVSLTRNRLSYAVVSQTFRRLVVDAGVGIGSSSPPRLHDLRHTFAVRTLLGWYRDGQDIQAKLPALSTYLGHREPASTYWYLSATPELLALAAARQDTAWSAARS
>NZ_CP017146|1857011:1932211|1867484_1868036_-|WP_161886106.1|DBSCAN-SWA
MHFAPDTEDLLAFNVALANTVPSSTRSGTDELSSTLQLQALLAIHGYTGRVDRDDAELGDVRAARLELRRIWALDRDSMASEVNAMLRDTRALPQLARHDGFDWHLHATRADAPLAERIRAEGALALVDVIRSDGTDRLRICEADDCEGLFADLSRNGSRRYCTVRCGNRMNMVAHRRRQSAE
>NZ_CP017146|1857011:1932211|1921896_1923798_-|WP_161886148.1|DBSCAN-SWA
MSMEGAAWSSLYKISTARDGKHGFSRESVRRIMTFAVPYRSKLLIFITLSTVGAFLAVATPVLAGQVVDVIVARGEVTTIVWLAGVIALVAVADAAVSLVTRWYSARIGEGVILDLRTTVFNHVQKMPIAFFTRTRTGALVSRLNNDVIGAQQAFSGTLSGVVTNLVALILTLIVMLSTSWLVTVLAVIMLPIFLVPARRMGSRLAALRREAADHNSAMSTQMTERFSAPGATLVKLFGRPDEEADEFRVRAARVRDIGVRTAMLQFVFFTALMLVSALALALVYGLGGFLALAGQLNTGDVVTLALLLTRLYAPLTSLANARVEIMSAVVSFERVFEVLDLDPLIKEKPDAVAIPEGPVAVEFDDVRFAYPSADKVSLASLEEVSTLDTRGGEEVLHGVSFRIEPGQTVALVGTSGAGKSTIAQLLSRLYDVDSGAVRFAGTDVRDVTFASMRHTLGMVTQDGHLFHETILSNLRLARPEASDDEVWDAIRRARLEPLVRSLPDQLDTMVGERGYRLSGGERQRMTIARLLLAQPRVVILDEATAALDSTSEAAVQAALSEALEGRTAMVIAHRLSTIRSADLILVVENGSIVERGTHEELLAVGGRYEELHRTQFAVQKSVAADEEALSTS
>NZ_CP017146|1857011:1932211|1906781_1907195_+|WP_161886133.1|DBSCAN-SWA
MSPRERRAPRRRSATESLLSIVLVLEALLVFFLTLVVFALDALPPAAAFIGGGVLFVALLALGRVMRYEWAVWVGWLMQLVIILTGLLEPLMFGIGAIFVALWTYCFITGRRLDKRNAALFPDDSTDTSTTDTKETP
>NZ_CP017146|1857011:1932211|1913128_1913437_+|WP_161886138.1|DBSCAN-SWA
MVYAVVRAGGRQEKVEVGTIVVLDRIKADKDGNIELAPVLLVDGDSITHDASELAKVTVTAEVITDLRGPKIVIQKFKNKTGYKVRKGHRSELTRVKITSIN
>NZ_CP017146|1857011:1932211|1871130_1872015_-|WP_161886110.1|DBSCAN-SWA
MALDYRGTTALITGASSGLGTEFARQLAARGANLVLVARRLDRLDSLANELTASHGITATTITADLAAPGAAANLHADLGERGIRISTLINNAGFGTRSRFENEAAGRIHEEVSLNVTALVELTHAFYAQLQEGRGALVTLASTAAYQPVPLMAVYAASKAFVLSFTEALWYENKDTALLVLALSPGATRTEFFDVAGAGARVGDFEEPADVVGLALSTLDSKNPPPSVVSGARNRAMSIASTLAPRRTVVNLTGSMTGRNPACGLNDEGVLTTKARHCCAGPSSSVHAVQLWS
>NZ_CP017146|1857011:1932211|1877020_1878196_+|WP_161887448.1|DBSCAN-SWA
MIQPISAGLIGAITGFASSFAIVIAGLRAVGATEEQAASGLLILCLTQGLVAIVLSWRFRMPLSFAWSTPGAALLVTAEATTGDFSAAVGAFIVCGALIAVTGAWPALGRAITRIPRPIASAMLAGILLPICIAPVTASVAEPLLALPIVIVWLVLSRLAPRWAVPSAMIVTAIVVALSVGTGWLGAGVVAPQLSFVPPSFDLLVIVSLGLPLFVVTMAGQNVPGFAVLSTLGFPPPRPAPILIGSGLVSMGGALFGGHVINLAALTAAIMAGPDAHPEHAKRWIAAVAGGAFYLVLGLGAGLATALVTASPPILITAVAGLALIGAFISSVTAALETPEHRPVAAITFLVVASGIVIGGIGSAFWGLVVGGLAMLWLGFRRRPAPARTAP
>NZ_CP017146|1857011:1932211|1858479_1860384_-|WP_161886103.1|DBSCAN-SWA
MEQLPNTLRDTADTVAGLGACAGEFTALDDASLFAAQRSVTALRRAVDTYAAWIAAAIAKHSDRALGHAGMAISAGFVSAEALIQSISGSTRAEAAKLVQIGTLLAETEAAEALAAADPTATATGGTPTAGAPTAGAPTAGAPTAGAPVSDPGSPASPGPATDPAEPRFPVGMPVWQAPIARAVTAGLLSLDGAEAIRRGLGGIDDAVTAEQLTAAAEHLITAINPSNPSNPSNPGNPGSAGAGRVLGADEVQRLARRLRDELDSDGIRRREKEQYDLRAVRKWRTADGMHHGIWHLHPEDGALLDSALSTILSPRRGGPRFIDPEEKAKAQKLVEDPRTDEQILADALIGMIRIATDADPGTMFGSRRPAVRVIITKKDLTTNTTPTAGTSTDASTGTGTGTGTPSGPTLPVLPVLPVLPPPSQSAQPLAPPHPAQPPLPPPPPPRLRLPGISADQGWIEGTLDPISIETIQRNLCDTGHIPVLFDDDGQCLNVGHTRRHFTARQRIALATRDGGCMFPSCDRPPSWCEAHHIKHWDRDNGPTNIDNGILLCRRHHLLLHDNHWEITNTNNNYWLQPPRNIDPTQTLILLPSRTPTITAITAIARRNASPSLSGWCETSRVMRGVLGEGGERT
>NZ_CP017146|1857011:1932211|1857011_1858061_-|WP_161885076.1|integrase,transposase|DBSCAN-SWA
MTAGTVLDDAFTALIGLAVTVVAACALTGRSRATHYRRISPPVRKIDPIPQAARAKPPSTLSETERGQVLAVINSPAYQDLSICQIWARELDEDRYHCSMSSMYRIARAAGQTRERRRLATHPAKVKPELVALGPSQVWSWDITKLRGPRKGVWYHLYALIDIYSRYSPSHVVCAAEDSVVARDFIDDAIGRNGTAPHTVHADRGTSMTSKPVSALLADLGITRTHSRPRVSNDNPYSEAQFKTLKYVPDFPHHFYSLAEAKQFCDGFFTDYNHIHHHSGIGWHTPASVHFGTYQDIDQQRSVTLNRAFNEHPERFTRRPRPPQIRTEVWINEPQKEALPINDQTTQTV
>NZ_CP017146|1857011:1932211|1887007_1888975_-|WP_161886122.1|DBSCAN-SWA
MSSYRWTAEEQAELAESMLQFNIEADAEMAARGYRPGVGLPFEGMPAGLFPHDPDLDDPRWADEDDYPGVPDCPGQPGRAGEASQAGQPGQASQAGEAVQAGAGLDGGRGYPFGVAAGPGGAGEAMGRLIDALERVEQGIAGLMGDRAVLFEQALVLAEAGTDRTRAGSRQLALRSVRAELGAALRIPERTIDALLGVGRSLVHELPATLEALRGGLISYRHAQVMVDQTAGLPAAARVVLEGQALPYARRLTASKFTQKARVLRELLDPDSITQRHARAREDREVRLDPQQDGLALLSQLLPAPEAVAIFTRLTDTAIALQGPLEVRTLAQLRADIFSDVMLDSTTTTAGDDSGNVDRNVDRNDTGNGNGSGNGSGSGNGSGSGSGSGGDGPLGMVSRRTRRGVARRNRAVRVTLMRAGRRVGWGRSGIRGRGSLRDRYFDTRPRLSVTVPALVLLGMSEEPGSLDGYGPIDPNTARLLAAGAPGMIRLLTHPETGAILSVGRDRYRVPTDLRNFLRVRDETCRFPGCSRQAEQCDIDHTLQWQHQHPTAHYNLAHLCPKHHTIKDETNWAVAHTRDGTGALEWTSPAGRTHITEPATIITSGVHDNLQRALHTAEHTQGTDQTADEAARAQRTDDQRTDARGADAEHEDPPPF
>NZ_CP017146|1857011:1932211|1891205_1891829_-|WP_161886124.1|DBSCAN-SWA
MTNARGRPHASSCEMLQEAAFDLFLENGYAGTTVAQITQRAGVSRATFFNYFSAKSDVFWIDLDDVLARLPDALAATDARAPVMQAMCSAIVAASTALGPAKVPWALTHLTLVGDIGELQSSAMSRLASQARVLSEFITTRIGGDAESALIARSASFGAIGAVIAAAQTWADASTKRGELGPYLSAALAPLCHGVQAAIDAMPPGEL
>NZ_CP017146|1857011:1932211|1899220_1900153_-|WP_161887450.1|DBSCAN-SWA
MTDFRLPLGDIVSEGIDVLTESLRPVFDLIRFVLLALYDAVEFLLLSPPFWVIILIAAGLAYFVKGWKFALGTIVGLLVIVGVNQWDNAMASLALVLVASAIAIAISVPLGIIAARSDRSSAVIRPILDFLQTMPAFVYLVPALILFRIGVVPGIVATIVFALAPGVRFTELGIRGVDTEVVEAGHAFGSSPWRILRQIQLPLAMPTIMAGINQVIMLSLSMVVIAGLVGGGGLGSDVVQALSRIDVALGFEAGLAVVIIAIYLDRLTAALSGKRRKMWTPWRRKVTPTETAPSPAPAAATKDAPVGASV
>NZ_CP017146|1857011:1932211|1920489_1921473_+|WP_161886147.1|DBSCAN-SWA
MPAIELPSWRGEPGDRARARLAIDRWAGSLAMARLVESFGGTTDDREGRELLDYLGEFSAAHWDFRRGRERNLASDAALSLTQSVLVVEVAPQLGLTGRERPTRSRYDTMLLTGGMVRAGIVKPRFAAQLLKDGLSVSHIAFLGGFRAFGGDEHALAGELGVDGGDEVEAMVAGMRRAFGSLGDPVVERHVADTPHASWCHYSWSTGGVRLSVVAAPSSEPSARRANTADTFRFWAAHRRSPAERSVLVVTTPIYVPYQAAGAVEALGVEQGLAVETVGVDASSSDLGALTQQFLPQHHLQEVRSAIRAMQALRARVTGIAEHTGTE
>NZ_CP017146|1857011:1932211|1895352_1896915_+|WP_161886127.1|DBSCAN-SWA
MSFVSVRNLRVRFGRRTVVDGVSFDIAPGECLAIVGESGSGKTITARALLGLAPDGADVSTDELVVAGVDASAYTGAEWRSVRGRLVGLVSQDALVSLDPMRRIASEVAEPIEVHEGGLSRSEVDARVLRMLSNVAIPSPETRARQYPHELSGGLRQRALIASALAAAPRLLVADEPTTALDATVQSKILELLGSLKEAGLALLLVSHDLSLVSQIADRIAVMQHGRIVETAAAADLLANPTHPYSRALLDAVPTGHAVRRDGGEIVLAARSLVKQYPAPHRTTTVALDDVSLELRAGTTLGIVGESGSGKSTLARLLLAIERPDSGEVLLRGSRWSSLAESARRRMRGGIQLIEQDPASSFDPRYTVRRILAEAVAITDTRANRPARILELLEQVGLSAVHLGRRGHELSGGQRQRVAIARALARRPSILVCDEPVSALDVQVQAQVLALLQNLQASTGLALVVISHDLAVIAQLSDTVLVMRHGVVVESGEASEVLTNPNHPFTRELLDSLPAGRILP
>NZ_CP017146|1857011:1932211|1907191_1907611_+|WP_161886134.1|DBSCAN-SWA
MTHVEETLVLIKPDGVVRNLTGEILRRIEAKGYKLVDIKLVEADRGRLGTHYEEHAGKPFYEPLLEFMESGPSVAIRVAGNRVIEGFRVLAGTTDPTTAAAGTIRGDLGRDWGLAVQQNLVHGSDSPESAERELALWFD
>NZ_CP017146|1857011:1932211|1920097_1920484_+|WP_161886146.1|DBSCAN-SWA
MTASTHSIQLLQRAAAAADSKQAEDLVALDVSGPLPLTDIFLIATGRNERNVVAIASEIEDQLIESGSKPLRREGRAEGRWILLDFGDLVVHVFHEEDRMYYSLERLWKDCPVVPIELPTQIEAPEAD
>NZ_CP017146|1857011:1932211|1865303_1867424_-|WP_161886105.1|DBSCAN-SWA
MSAQVHQVHLPFSSLDDFIALPRIEGLALSPDGHRVVLTVATLARDSTSYERALWAVPADGTGAPTRLTRSAKGESGVAFTGSGDVMFVSGRPDAAAEKDTEAAQLWLLPASGGEARAVTRLAGGVSGIAATATSSDTIVITADLLPSADGLEADAAARKNRSDKKVSAILHESYPVRYWDHDLGPAEPHLLSLDLSNLAESISAPVTADPNPDPAAAAAAAAAYPAELPRPNDLTPAPGRAGDTAGQALTPDGRTMIASLRVREQRSGRHVLVAIDVESGQRTTLFDEDRVHFQSPVVSRDGSRVAFVRSAFSTPEGPADQEIWVAGIDGSEPRRLGADWDRWPSSTIFDLGDESLIVTADHGGRGPIFRIPLDGSAAAQLTSDDFSYTHVAVDPTTGDLVALRSSWMAPSHPVRITRAGDVVPLATPATPATLPEAPGSITEVETVAEDGSPLRAWLLLPDGSDAQHPAPLLLWIHGGPLNSWNAWSWRWSPLLAVARGYAVLLPDPALSTGYGLDFIARGWDAWGTKPYTDLLAITDATEARPDIDAAKTAAMGGSFGGYMANWIAGHTDRFTAIVSHASLWALDQFNGTTDNSQYWQSIFSPQGMLDSSPHHSVRDISTPMLVIHGDRDYRVPVGESLRLWSELAEHHAEPDGTTRHKFLYFPNENHWVLGPQHAVVWYETVFAFLDQHVHGADWKRPEALG
>NZ_CP017146|1857011:1932211|1929096_1930296_+|WP_161887452.1|integrase|DBSCAN-SWA
MAGTRRKAGQLRPHVEGYQAWLACQGYTTGTIRNMLKDLGQVGSWLSAEGLTAEHLNEERIGMFLSARRAAGRRRIPGPRAMVPLLSYLREAGIVAQPTPVMSPLGALLSSYRSWLIRERGLAPGTVLRYEKAARRFLEESSTGGVFDTSVLTGADVNAFLLRECARVSAGSAKGRVAELRSILRFLYLEQITPLQLGAAVPPVGGWRLATLPPPAMASADVQLLLDGCDRSTVVGVRDFAMMMLVARLGLRSIEVARLQLGDVDWRAGEILVRGKGRRHDRLPLPAEVGEALVAYLLSGRNPADAVHVFLTCRAPCRPVRADLVGDVVERACKRAGLPRVGPHRLRHALAGEMLRKGAGLIAISQVLRHQDLATTALYAKVDLRTLREVAQPWPGVRR
>NZ_CP017146|1857011:1932211|1913878_1915432_+|WP_161886140.1|DBSCAN-SWA
MATFVDQVTLHLKAGHGGNGCVSVKREKFKPLAGPDGGNGGDGGDIVLVSDTQTTTLLGYHRAPHRTSPHGGPGMGDHRAGYHGEGMVLPVPVGTVVKSTDGTELIDMVEPGMRFVVALAGQGGLGNASLASTKRKAPGFALLGTPGWEGDVLLELKVVADIALVGYPSAGKSSLVAAISAAKPKIADYPFTTLHPNLGVVESGDTRYTVADVPGLIEGASEGKGLGLEFLRHVERCTALLHVLDCATLEPGRDPISDLDIILGELAAYPVPEGQLPLLERPQLVALNKIDVPEARELAELVRPELEARGYRVFDISTVSHEGLRQLSFALGELVAQGRAAKAAEPEKPRIVIRPRAVNESDFVIKVEGGSGGNIYRVVGQKPERWVAQTDFTNDEAIGYLADRLAKLGVENELFKSGAVAGSTVVIGRDGHVFDWEPTLSSTAELATAPRGSDPRLSEAQRSTHSRRRETYLERMDAKTAARDEMMRERNAGMWNDDEGFEVERPGAPDDTAAKED
>NZ_CP017146|1857011:1932211|1869778_1871146_+|WP_161886109.1|DBSCAN-SWA
MKTTVEKLSPTRVKLTIAVTPDELKPSVDHAYTHLAESINIPGFRKGKVPPPIIDQRVGRGEVLNHAVSDGLDKFYRLAVTEEKIRPLGRPEADVTGLPELKDFSGDLVIVVEVDVRPEFTLPSIDGLELTVDTATVEPDEVETELQNLLARFGTLVTVERPAKTGDFAQIDLVASIDGTEVDTANAISYEVGSGDLIDGIDEALDALSAGETTTFESKLLGGDNEGQTAQITVNLLAVKERELPAADDDFAQIASQFDTIDELKADIEQQVIKSKVFGQGAQARDQVVDKLLESVEIPVPEKLVEDEVHRHLENENRLEDAEHRAEVAESSEKTFRTQILLDSIAEQEKVKVSQNELTQYLVQGAAQYNMEPGEFIKVLDQNGQIPGMIGEVARAKALAIVLSRANVVDGNGDVVDISSFTATALSDAGDDSDASDFVEAASTADDDHEGHDHS
>NZ_CP017146|1857011:1932211|1881836_1883093_-|WP_161886118.1|DBSCAN-SWA
MRISMVSVDASPLAAIGGLDACGRSVYVAALATALARRGHHVTVYTRRDVPGLPDRVEISPRFELVHLTAGPTEQLPEEELLTHLADLADGLGVDWLRSKPDIVHSHLWTSGIAAIDAARRIGAPRDIPVAQTFHGLGVVSHRNGATAETSPPDREWLEPWVARNVDSVIGTCTDEAFELKSLGIPTGAISVVPCGVDLRRFGTSGEIEERARPLRLVTVGRLQPSNRFDLVIQAFARLVDEGVDAELIIVGGAVGAHAGDSDPATAMLRTLARELGVADRVELRGPLEHASMPAILRSANAVICAPRHGTSGVVALEAMACGIPVVASGVGGLIDTVIDGITGVHVPPQDAEAIATALSCLLADDGRMASLGVAGSRRVAARFTWEQVAIDTERAYRKTARRAKERVIARASEGATR
>NZ_CP017146|1857011:1932211|1893695_1894514_+|WP_161887449.1|DBSCAN-SWA
MLGVQAQVSEQVKAQIRADWGLDDPPLARYLQYLGRLVTGDLGESYQLRQSVSSVIGEQLPATLQLTLLALAFALSLAAIATLAARGRRSTRIVSLVELTAVSSPTFWTGLVLIAVFVFQLGWFPIAETGSLRALVLPALTLALPVAGIISQVLRQGLDAASAQPFATTAIARGLGGGRLLLRHTLRHAAADSVTLVGYLVGTLIGGAVLVETVFARPGLGRVTLRAIIDRDLPVVLGIILLAAVTFALLNLAVDVLYRWIDPRLRTGSAAT
>NZ_CP017146|1857011:1932211|1925622_1926054_+|WP_161886150.1|DBSCAN-SWA
MGVCDVLDGWDDAGPNSGRVDDVRGFVDELLESWGFDAPNWSDQMPAGYEDAAGVYTRNDDTIHLNPDIFEGDASDALNVAIHEGLHASMDQMGWNDPDLLEELMAAGAGYQALEDLVQGCQNPTESGAPSDMPSYPWVSSEG
>NZ_CP017146|1857011:1932211|1875721_1876996_+|WP_161886114.1|protease|DBSCAN-SWA
MARIGESADLLKCSFCGKSQKQVQQLIAGPGVYICDECVELCNEIIEERLAEAGEEVSSEFDLPKPKEIFNFLEEYVIGQEPAKRALSVAVYNHYKRIRSRNTLTSADAVIDDVEIAKSNILLIGPTGCGKTYLAQTLAKRLNVPFAVADATALTEAGYVGEDVENILLKLIQAADYDVKRAETGIIYIDEIDKIARKAENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQEFIQVDTTNVLFIVAGAFAGLEEIISSRAGKKGIGFGAPLHSKGDDVNLFGEVLPEDLHKFGLIPEFIGRLPVVTTVTQLDQVALMAILTEPRNALVRQYQRMFEIDGVELEFEHDALEAIADLAVLRKTGARGLRAIMEEVLGPIMFEVPSSSDVARVIVTKSAVVENGAPTIILREVRTEKSA
>NZ_CP017146|1857011:1932211|1926371_1926884_+|WP_161886151.1|DBSCAN-SWA
MPQIVTGPNRAALVADGIYSTAAAEMIERARQRCLASIFIADLLEQTQRGLGDIVDALANASWRGVDTRVILGGSRENFQIAATAVDAEAILRSEGVAVRWLLATPQRGSHAKFLVCDELSLLGSHNWSPGSFSGAQVQDSVLIDSAGMAGILQEKFEEQWRRADRGNRV
>NZ_CP017146|1857011:1932211|1902095_1905401_+|WP_161886131.1|tRNA|DBSCAN-SWA
MNYPKGFSPDAGAARPVSPSPNFPAIERGILAFWKGDETFRASIENREGCREWTFYDGPPFANGLPHYGHLLTGYAKDLFPRFQTMRGLQVHRRFGWDTHGLPAELEAMRQLGITEKHQIDEMGIAAFNDVARKSVLEYTGEWEEYVTRQARWVDFENDYKTLDVTFMESVIWAFKQLYDKGLAYEGFRVLPYCWHDQTPLSNHELRMDDDVYKMRQDQSVTVTFPLDGVKAEALGLTAVKALAWTTTPWTLPTNAALAVGPDIEYSVIPSGPLGAGDGSAEGVASYLLASDTVGAYLKDLGYASIDEARAAVTSTVLGSELDGVTYDRLWDYYADAEEWGTENAWQILVADYVATGEGTGIVHQAPAYGEDDQVVCAAAGIPVIISVDDGGKFLPQIEEVAGLQVFEANKTLIQLLRTGGRLLRLASYEHSYPHCWRCRNPLIYKAVSSWFVRVTQFRDRMGELNEQINWVPENVKHGQFGKWIGNARDWSISRNRYWGSPIPVWKSDDPEYPRIDVYGSLDELEADFGVRPTDLHRPYIDELTRPNPDDPTGTSTMRRIEDVLDVWFDSGSMPFAQVHYPFENQDWFENHNPADFIVEYIGQTRGWFYTLHALSTAIFDRPAFSNVVSHGIVLGSDGQKMSKSLNNYPNVSEVFDRDGADAMRWFLMSSSVIRGGNLVVTEEGIRESVRQFILPVWNTWYFFTLYANAAGYDATWRTDSSDVLDRYLLAKTRLLIHEVEAQLEALDSPAATATLRDFADVLTNWYVRRSRDRFWAGDDRDAFDTLYTVLETVTRVAAPLIPLIGEEIWQGLTGGRSVHLTDWPDAGAFPADAALVSAMDRVREIASSALALRKATGKRVRLPLAELTVVAESIDGLSDFSDILRDELNVKKVSLRVLEESSLGEFGITKRLSVNSRVVGPRIGKNVQVVIRASKSGDWEQTDGGVVVGGIELLAGEFELELQSADDSKAIEFLPGGGFVLLDTATTPELEAEGLARDLVRAIQDTRKAAGFKVSDRIDLTLSFGSESEFSGTRAYESMIGEETLATTLSTSWHAPVELDTAAAVAGEAGAYRATVPAGRYSNNEAIVIELSVHGRGVDV
>NZ_CP017146|1857011:1932211|1917897_1918461_+|WP_161886144.1|DBSCAN-SWA
MGGTFDPIHNGHLSAASEVRQHFNLDEVVFVPTGVPYQKTGVTASEHRYLMTVIATASNPSFTVSRVDIDRIGPTYTIDTLRDLRAERPDADLFFISGADAVAQIIDWKDAVELFELAHFVAVTRPGHPLSVSGLPEQDVSLLEVPALAISSTDCRSRVNRGFPVWYLVPDGVVQYISKHHLYRSTT

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_161885076.1|1857011_1858061_-|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_161886103.1|1858479_1860384_-	DUF222 domain-containing protein	NA	NA	NA	NA
WP_161886104.1|1864917_1865091_-	DUF2510 domain-containing protein	NA	NA	NA	NA
WP_161886105.1|1865303_1867424_-	S9 family peptidase	NA	NA	NA	NA
WP_161886106.1|1867484_1868036_-	CGNR zinc finger domain-containing protein	NA	NA	NA	NA
WP_161886107.1|1868108_1869065_+	EamA family transporter	NA	NA	NA	NA
WP_161886108.1|1869091_1869412_+	hypothetical protein	NA	NA	NA	NA
WP_161886109.1|1869778_1871146_+	trigger factor	NA	NA	NA	NA
WP_161886110.1|1871130_1872015_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_161886111.1|1872094_1873303_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_161886112.1|1874066_1874735_+|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	1.2e-39	44.4
WP_161886113.1|1874827_1875544_-	copper resistance protein CopC	NA	NA	NA	NA
WP_161886114.1|1875721_1876996_+|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	3.4e-136	60.2
WP_161887448.1|1877020_1878196_+	benzoate/H(+) symporter BenE family transporter	NA	NA	NA	NA
WP_161886115.1|1878301_1879315_+	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_161886116.1|1879363_1879768_+	hypothetical protein	NA	NA	NA	NA
WP_161886117.1|1879764_1881810_-	M3 family metallopeptidase	NA	NA	NA	NA
WP_161886118.1|1881836_1883093_-	glycosyltransferase family 1 protein	NA	NA	NA	NA
WP_161886119.1|1883220_1883469_-	hypothetical protein	NA	NA	NA	NA
WP_161886120.1|1883523_1884174_-	hypothetical protein	NA	NA	NA	NA
WP_161886121.1|1884173_1886777_-|tRNA	valine--tRNA ligase	A0A2K9KZB8	Tupanvirus	3.9e-163	37.8
WP_161886122.1|1887007_1888975_-	DUF222 domain-containing protein	NA	NA	NA	NA
WP_161886123.1|1889355_1890171_-	hypothetical protein	NA	NA	NA	NA
WP_161886124.1|1891205_1891829_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_161886125.1|1891905_1893549_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_161887449.1|1893695_1894514_+	ABC transporter permease	NA	NA	NA	NA
WP_161886126.1|1894510_1895356_+	ABC transporter permease	NA	NA	NA	NA
WP_161886127.1|1895352_1896915_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.5e-13	31.2
WP_161886128.1|1896914_1898183_+	amino acid permease	NA	NA	NA	NA
WP_161886129.1|1898269_1899178_-	glycine betaine ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_161887450.1|1899220_1900153_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_161886130.1|1900152_1901460_-	glycine betaine/L-proline ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.6e-30	37.5
WP_161886131.1|1902095_1905401_+|tRNA	isoleucine--tRNA ligase	A0A2K9V7W4	Bandra_megavirus	4.8e-158	34.0
WP_161886132.1|1905348_1906785_+	bifunctional folylpolyglutamate synthase/dihydrofolate synthase	NA	NA	NA	NA
WP_161886133.1|1906781_1907195_+	DUF4233 domain-containing protein	NA	NA	NA	NA
WP_161886134.1|1907191_1907611_+	nucleoside-diphosphate kinase	A0A2K9L0Y6	Tupanvirus	1.8e-25	46.3
WP_161887451.1|1907607_1908318_-	vitamin K epoxide reductase family protein	NA	NA	NA	NA
WP_161886135.1|1908586_1911349_+	Rne/Rng family ribonuclease	NA	NA	NA	NA
WP_161886136.1|1911389_1912496_-	calcium/sodium antiporter	NA	NA	NA	NA
WP_161886137.1|1912610_1912886_-	DUF4031 domain-containing protein	NA	NA	NA	NA
WP_161886138.1|1913128_1913437_+	50S ribosomal protein L21	NA	NA	NA	NA
WP_161886139.1|1913467_1913737_+	50S ribosomal protein L27	NA	NA	NA	NA
WP_161886140.1|1913878_1915432_+	GTPase ObgE	NA	NA	NA	NA
WP_161886141.1|1915440_1916259_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	2.7e-33	46.3
WP_161886142.1|1916307_1917591_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	4.8e-90	44.8
WP_161886143.1|1917651_1917846_+	hypothetical protein	NA	NA	NA	NA
WP_161886144.1|1917897_1918461_+	nicotinate-nucleotide adenylyltransferase	NA	NA	NA	NA
WP_161886145.1|1918457_1920062_+	hypothetical protein	NA	NA	NA	NA
WP_161886146.1|1920097_1920484_+	ribosome silencing factor	NA	NA	NA	NA
WP_161886147.1|1920489_1921473_+	hypothetical protein	NA	NA	NA	NA
1921613:1921648	attL	NA	NA	NA	NA
WP_161886148.1|1921896_1923798_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	8.9e-40	26.0
WP_161886149.1|1924314_1925151_-	M23 family metallopeptidase	NA	NA	NA	NA
WP_161886150.1|1925622_1926054_+	hypothetical protein	NA	NA	NA	NA
WP_161886151.1|1926371_1926884_+	hypothetical protein	NA	NA	NA	NA
WP_161886152.1|1926993_1928064_+	hypothetical protein	NA	NA	NA	NA
WP_161887452.1|1929096_1930296_+|integrase	tyrosine-type recombinase/integrase	A0A1P8DJ76	Virus_Rctr85	2.2e-07	24.5
WP_161886153.1|1930292_1931225_+|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_161886154.1|1931221_1932211_+|integrase	tyrosine-type recombinase/integrase	A0A142F1N9	Bacillus_phage	1.6e-16	23.7
1933130:1933165	attR	NA	NA	NA	NA