CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP026083	Streptococcus agalactiae strain YZ1605 plasmid pYZ1605, complete sequence	0 crisprs	NA	0	0	0	0
NZ_CP026082	Streptococcus agalactiae strain YZ1605 chromosome, complete genome	3 crisprs	RT,cas3,DinG,cas9,cas1,cas2,csn2,csm6,DEDDh,csa3	2	10	9	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP026082_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP026082_1

968280-968909

TypeII

II-A

Consensus_repeat	Method
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	PILER-CR
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CRISPRCasFinder
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CRT

9 spacers

csn2,cas2,cas1,cas9,RT

The CRISPR arrays of NZ_CP026082_1

>merge|NZ_CP026082|1|968280-968909|PILER-CR,CRISPRCasFinder,CRT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACCATTTTTTTGTAATACTTATCTTTATTTGAGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTCAGAAAAAGAAATATATAGCGCCTACAATGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTCGCAATAATTACTATATGATTAAGCGCAAGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTATCACGCAAGCGTGATTAATGCTAAGCAAGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACCTCTTCACCGTTCCAAATTTTATCATCTATGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACAGAGTTACAATAAGTTAGAAAATAAAATTAGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACGTCTTTATCATGAAGCGGACTAACCGCTATGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTGGTTATACATTTACTAATCCATCAGCATTGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACAGAGTTAACTAATTTTCATGCTATCACAAAGTTTTAGAGCTGTGCTGTTATTATGCTAGGGCACCA

>NZ_CP026082|1|1|968280-968777|PILER-CR
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CATTTTTTTGTAATACTTATCTTTATTTGA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TCAGAAAAAGAAATATATAGCGCCTACAAT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TCGCAATAATTACTATATGATTAAGCGCAA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TATCACGCAAGCGTGATTAATGCTAAGCAA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CTCTTCACCGTTCCAAATTTTATCATCTAT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AGAGTTACAATAAGTTAGAAAATAAAATTA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GTCTTTATCATGAAGCGGACTAACCGCTAT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC

>NZ_CP026082|1|1|968280-968843|CRISPRCasFinder
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CATTTTTTTGTAATACTTATCTTTATTTGA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TCAGAAAAAGAAATATATAGCGCCTACAAT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TCGCAATAATTACTATATGATTAAGCGCAA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TATCACGCAAGCGTGATTAATGCTAAGCAA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CTCTTCACCGTTCCAAATTTTATCATCTAT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AGAGTTACAATAAGTTAGAAAATAAAATTA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GTCTTTATCATGAAGCGGACTAACCGCTAT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TGGTTATACATTTACTAATCCATCAGCATT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC

>NZ_CP026082|1|1|968280-968909|CRT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CATTTTTTTGTAATACTTATCTTTATTTGA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TCAGAAAAAGAAATATATAGCGCCTACAAT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TCGCAATAATTACTATATGATTAAGCGCAA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TATCACGCAAGCGTGATTAATGCTAAGCAA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CTCTTCACCGTTCCAAATTTTATCATCTAT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AGAGTTACAATAAGTTAGAAAATAAAATTA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GTCTTTATCATGAAGCGGACTAACCGCTAT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TGGTTATACATTTACTAATCCATCAGCATT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AGAGTTAACTAATTTTCATGCTATCACAAA
GTTTTAGAGCTGTGCTGTTATTATGCTAGGGCACCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP026082.1\|WP_000653355.1\|961174_961831_+\|TIGR01906-family-membrane-protein	unknown	unknown	gnl\|CDD\|226884
NZ_CP026082.1\|WP_000438312.1\|969445_969862_+\|nucleoside-diphosphate-kinase	unknown	unknown	gnl\|CDD\|179085
NZ_CP026082.1\|WP_001292556.1\|974793_976071_-\|group-II-intron-reverse-transcriptase/maturase	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|275209
NZ_CP026082.1\|WP_000180007.1\|976666_977326_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224336
NZ_CP026082.1\|WP_161501841.1\|972076_974710_+\|pneumococcal-type-histidine-triad-protein	unknown	unknown	gnl\|CDD\|380193
NZ_CP026082.1\|WP_000665410.1\|977798_978233_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	unknown	unknown	gnl\|CDD\|234692
NZ_CP026082.1\|WP_000914659.1\|958542_959673_+\|oxygen-independent-coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|236309
NZ_CP026082.1\|WP_000065321.1\|981176_982280_+\|DUF2974-domain-containing-protein	unknown	unknown	gnl\|CDD\|371412
NZ_CP026082.1\|WP_000523795.1\|959676_960414_+\|acyl-ACP-thioesterase	unknown	unknown	gnl\|CDD\|366738
NZ_CP026082.1\|WP_000590706.1\|967513_968179_+\|type-II-A-CRISPR-associated-protein-Csn2	csn2	pfam09711_csn2_CAS-II-A	gnl\|CDD\|213408
NZ_CP026082.1\|WP_001019133.1\|969997_971830_+\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NZ_CP026082.1\|WP_000146565.1\|982330_982969_-\|CatB-related-O-acetyltransferase	unknown	unknown	gnl\|CDD\|100040
NZ_CP026082.1\|WP_000168905.1\|978384_981177_+\|cation-transporting-P-type-ATPase	unknown	unknown	gnl\|CDD\|223550
NZ_CP026082.1\|WP_000621142.1\|977334_977799_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP026082.1\|WP_000468671.1\|956902_958348_-\|IS1182-like-element-IS1563-family-transposase	unknown	unknown	gnl\|CDD\|226192
NZ_CP026082.1\|WP_000323544.1\|960414_961185_+\|TIGR01457-family-HAD-type-hydrolase	unknown	unknown	gnl\|CDD\|319832
NZ_CP026082.1\|WP_161501839.1\|956520_956892_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|131381
NZ_CP026082.1\|WP_161501840.1\|962205_966318_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	COG3513_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226044
NZ_CP026082.1\|WP_000929489.1\|966319_967189_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|274694
NZ_CP026082.1\|WP_000122194.1\|967185_967527_+\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043

Protein	Function_ID	Function_description	E-value
NZ_CP026082.1\|WP_000653355.1\|961174_961831_+\|TIGR01906-family-membrane-protein	gnl\|CDD\|226884	COG4478, COG4478, Predicted membrane protein [Function unknown].	8.37758e-51
NZ_CP026082.1\|WP_000438312.1\|969445_969862_+\|nucleoside-diphosphate-kinase	gnl\|CDD\|179085	PRK00668, ndk, mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated.	1.21474e-79
NZ_CP026082.1\|WP_001292556.1\|974793_976071_-\|group-II-intron-reverse-transcriptase/maturase	gnl\|CDD\|275209	TIGR04416, hypothetical_protein, group II intron reverse transcriptase/maturase. Members of this protein family are multifunctional proteins encoded in most examples of bacterial group II introns. These group II introns are mobile selfish genetic elements, often with multiple highly identical copies per genome. Member proteins have an N-terminal reverse transcriptase (RNA-directed DNA polymerase) domain (pfam00078) followed by an RNA-binding maturase domain (pfam08388). Some members of this family may have an additional C-terminal DNA endonuclease domain that this model does not cover. A region of the group II intron ribozyme structure should be detectable nearby on the genome by Rfam model RF00029. [Mobile and extrachromosomal element functions, Other].	5.32369e-174
NZ_CP026082.1\|WP_000180007.1\|976666_977326_+\|HD-domain-containing-protein	gnl\|CDD\|224336	COG1418, COG1418, Predicted HD superfamily hydrolase [General function prediction only].	2.66997e-33
NZ_CP026082.1\|WP_161501841.1\|972076_974710_+\|pneumococcal-type-histidine-triad-protein	gnl\|CDD\|380193	NF033189, internalin_A, class 1 internalin InlA. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface or secreted proteins with an N-terminal signal peptide, leucine-rich repeats, and usually a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin A (InlA), a class 1 (LPXTG-type) internalin.	7.37292e-23
NZ_CP026082.1\|WP_000665410.1\|977798_978233_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	gnl\|CDD\|234692	PRK00222, PRK00222, peptide-methionine (R)-S-oxide reductase MsrB.	6.40832e-86
NZ_CP026082.1\|WP_000914659.1\|958542_959673_+\|oxygen-independent-coproporphyrinogen-III-oxidase	gnl\|CDD\|236309	PRK08599, PRK08599, oxygen-independent coproporphyrinogen III oxidase.	0
NZ_CP026082.1\|WP_000065321.1\|981176_982280_+\|DUF2974-domain-containing-protein	gnl\|CDD\|371412	pfam11187, DUF2974, Protein of unknown function (DUF2974). This bacterial family of proteins has no known function.	1.82724e-105
NZ_CP026082.1\|WP_000523795.1\|959676_960414_+\|acyl-ACP-thioesterase	gnl\|CDD\|366738	pfam01643, Acyl-ACP_TE, Acyl-ACP thioesterase. This family consists of various acyl-acyl carrier protein (ACP) thioesterases (TE) these terminate fatty acyl group extension via hydrolysing an acyl group on a fatty acid.	3.68196e-111
NZ_CP026082.1\|WP_000590706.1\|967513_968179_+\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213408	cd09758, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	3.61399e-122
NZ_CP026082.1\|WP_001019133.1\|969997_971830_+\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NZ_CP026082.1\|WP_000146565.1\|982330_982969_-\|CatB-related-O-acetyltransferase	gnl\|CDD\|100040	cd03349, LbH_XAT, Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. Members of this class of enzymes include Enterococcus faecium streptogramin A acetyltransferase and Pseudomonas aeruginosa chloramphenicol acetyltransferase. They contain repeated copies of a six-residue hexapeptide repeat sequence motif (X-[STAV]-X-[LIV]-[GAED]-X) and adopt a left-handed parallel beta helix (LbH) structure. The active enzyme is a trimer with CoA and substrate binding sites at the interface of two separate LbH subunits. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients.	6.8383e-72
NZ_CP026082.1\|WP_000168905.1\|978384_981177_+\|cation-transporting-P-type-ATPase	gnl\|CDD\|223550	COG0474, MgtA, Cation transport ATPase [Inorganic ion transport and metabolism].	0
NZ_CP026082.1\|WP_000621142.1\|977334_977799_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	5.91796e-19
NZ_CP026082.1\|WP_000468671.1\|956902_958348_-\|IS1182-like-element-IS1563-family-transposase	gnl\|CDD\|226192	COG3666, COG3666, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	7.63275e-26
NZ_CP026082.1\|WP_000323544.1\|960414_961185_+\|TIGR01457-family-HAD-type-hydrolase	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.19143e-132
NZ_CP026082.1\|WP_161501839.1\|956520_956892_+\|hypothetical-protein	gnl\|CDD\|131381	TIGR02328, TIGR02328, conserved hypothetical protein. Members of this protein are found in a small number of taxonomically well separated species, yet are strongly conserved, suggesting lateral gene transfer. Members are found in Treponema denticola, Clostridium acetobutylicum, and several of the Firmicutes. The function of this protein is unknown. [Hypothetical proteins, Conserved].	2.02902e-76
NZ_CP026082.1\|WP_161501840.1\|962205_966318_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|226044	COG3513, COG3513, Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms].	0
NZ_CP026082.1\|WP_000929489.1\|966319_967189_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274694	TIGR03639, cas1_NMENI, CRISPR-associated endonuclease Cas1, subtype II/NMENI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.	2.54315e-139
NZ_CP026082.1\|WP_000122194.1\|967185_967527_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	2.38084e-52

>NZ_CP026082.1|WP_000590706.1|967513_968179_+|type-II-A-CRISPR-associated-protein-Csn2
MIKINFPILDEPLVLSNATILTIEDVSVYSSLVKHFYQYDVDEHLKLFDDKQKSLKATELMLVTDILGYDVNSAPILKLIHGDLENQFNEKPEVKSMVEKLAATITELIAFECLENELDLEYDEITILELIKALGVKIETQSDTIFEKCFEIIQVYHYLTKKNLLVFVNSGAYLTKDEVIKLCEYINLMQKSVLFLEPRRLYDLPQYVIDKDYFLIGENMV
>NZ_CP026082.1|WP_000122194.1|967185_967527_+|CRISPR-associated-endonuclease-Cas2
MSYRYMRMILMFDMPTETAEERKAYRKFRKFLLSEGFIMHQFSVYSKLLLNNTANNAMIGRLKVNNPKKGNITLLTVTEKQFARMVYLHGERNTSVANSDSRLVFLGDSYDQD
>NZ_CP026082.1|WP_000929489.1|966319_967189_+|type-II-CRISPR-associated-endonuclease-Cas1
MAGWRTVVVNTHSKLSYKNNHLIFKDSYQTEMIHLSEIDILIMETTDIVLSTMLIKRLVDENILVIFCDDKRLPTAMLMPYYARHDSSLQLSRQMSWIEDVKADVWTSIIAQKILNQSFYLGECSFFEKSQSIMNLYHDLEPFDPSNREGHAARIYFNTLFGNDFSREQDNPINAGLDYGYSLLLSMFAREVVKCGCMTQFGLKHANQFNQFNLASDIMEPFRPIVDRIIYENRQSDFVKMKRELFSMFSETYSYNGKEMYLSNIVSDYTKKVIKSLNSDGNGIPEFRI
>NZ_CP026082.1|WP_161501840.1|962205_966318_+|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MNKPYSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTAADRRLKRTARRRYTRRRNRILYLQEIFAEEMSKVDDSFFYRLEDSFLVEEDKRGSKYPIFATMQEEKYYHEKFPTIYHLRKELADKKEKADLRLIYLALAHIIKFRGHFLIEDDRFDVRNTDIQKQYQAFLEIFDTTFENNDLLSQNVDVEAILTDKISKSAKKDRILARYPNQKSTGIFAEFLKLIVGNQADFKKHFNLEDKTPLQFAKDSYDEDLENLLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKASLPEKYQEIFADSSKDGYAGYIEGKTNQEAFYKYLSKLLTKQEGSEYLLEKIKNEDFLRKQRTFDNGSIPHQVHLTELRAIIRRQSEYYPFLKENLDRIEKILTFRIPYYVGPLAREKSDFAWMTRKTDDSIRPWNFEDLVDKEKSAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRFLAEGFKDFQFLNRKQKETIFNSLFKEKRKVTEKDIISFLNKVDGYEGIAIKGIEKQFNASLSTYHDLKKILGKDFLDNTDNELILEDIVQTLTLFEDREMIRKRLDIYKDFFTESQLKKLYRRHYTGWGRLSAKLINGIRNKENQKTILDYLIDDGSANRNFMQLIKDAGLSFKPIIDKARTGSHSDNLKEVVGELAGSPAIKKGILQSLKIVDELVKVMGYEPEQIVVEMARENQTTAKGLSRLRQRLTTLRESLANLKSNILEEKKPKYVKDQVENHHLSDDRLFLYYLQNGKDMYTDDELDIDNLSQYDIDHIIPQAFIKDDSIDNRVLVSSAKNRGKSDDVPSVEIVKDCKVFWKKLLDAKLMSQRKYDNLTKAERGGLTSDDKARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIRKVKIVTLKSNLVSNFRKEFGFYKIREVNNYHHAHDAYLNAVVAKAILTKYPQLEPEFVYGDYPKYNSYKTRKSATEKLFFYSNIMNFFKTKVTLADGTVVVKDDIEVNNDTGEIVWDKKKHFATVRKVLSYPQVNIVKKTEIQTGGFSKESILAHGNSDKLIPRKTKDIYLDPKKYGGFDSPIVAYSVLVVADIKKGKAQKLKTVTELLGITIMERSRFEKNPSAFLESKGYLNIRDDKLMILPKYSLFELENGRRRLLASAGELQKGNELALPTQFMKFLYLASRYNELKGKPEEIEQKQEFVVQHVSYFDDILQIINDFSNRVILADANLEKINKLYQDNKENIPVDELANNIINLFTFTSLGAPAAFKFFDKIVDRKRYTSTKEVLNSTLIHQSITGLYETRIDLGKLGED
>NZ_CP026082.1|WP_000653355.1|961174_961831_+|TIGR01906-family-membrane-protein
MKDKLLVVLTWIWIISLATLATIYIAWLIYPIEIQFLKLEKVVYLKAETIYYNFNKLMIYLTHPFISDLNMPSFPSSEDGLKHFADVKYLFTLAHGLFVILTFPVIYFLRHGWKQKSIFLYEGFFKIAIMLPIFIVVCAFLLGFDQFFTLFHEVLFPGDSTWQFNPLTDPVIWILPETFFLHCFIIFLLIYETITIILLIIGRKHLKLRKYKNKMQAL
>NZ_CP026082.1|WP_000323544.1|960414_961185_+|TIGR01457-family-HAD-type-hydrolase
MAYKGYLIDLDGTIYKGKSRIPAGERFIERLQEKGIPYMLVTNNTTRTPESVQEMLRGFNVETPLETIYTATMATVDYMNDMNRGKTAYVIGEEGLKKAIADAGYVEDTKNPAYVVVGLDWNVTYDKLATATLAIQNGALFIGTNPDLNIPTERGLLPGAGSLNALLEAATRIKPVFIGKPNAIIMNKALEILNIPRNQAVMVGDNYLTDIMAGINNDIDTLLVTTGFTTVEEVPDLPIQPSYVLASLDEWTFNEG
>NZ_CP026082.1|WP_000523795.1|959676_960414_+|acyl-ACP-thioesterase
MGLLYRETYEVPFYESDTNHYMKLPQLLALALQISAKQSLKLGIGDDIVFKRYGLVWVVTDYIIDIERLPKHAEKIVIETEAKAHNKLLCYRYFYIYGEDGQKIITISSAFVLMDFKTRKIHPVLDDITSIYQSQRIKKVIRGPKYHPIGDSKVKQYHVRYFDLDMNGHVNNSKYLEWMYDVLDLDFLSSHIPKKIDLKYIKEIQYGTDIKSHWYQDGLVTRHDIIGGDAIHAQARIEWQEKKED
>NZ_CP026082.1|WP_000914659.1|958542_959673_+|oxygen-independent-coproporphyrinogen-III-oxidase
MLKKPTSAYVHIPFCTQICYYCDFSKVFIKNQPVDAYLQALIREFRSYDITELRTLYIGGGTPTSISAVQLDYLLTELIRDLNLNTLEEFTIEANPGDLTVDKIEVLQKSAVNRVSLGVQTFNDKHLKRIGRSHNEAQIYSTIDALKTAGFQNISIDLIYALPGQTMDDVRSNVAKALSLNIPHLSLYSLILEHHTVFMNKMRRGKLHLPTEDLEAEMFEYIISEMERNGFEHYEISNFTKPGFESRHNLMYWENVEYYGVGAGASGYLDGIRYRNRGPIQHYLKGVSEGNARLSEEVLSKNEMMEEELFLGLRKKEGVSIGKFEQKFGTSFEKRYGQIVQELQSDGLLKENNGFIQMTKKGLFLGDTVAEKFIVE
>NZ_CP026082.1|WP_000468671.1|956902_958348_-|IS1182-like-element-IS1563-family-transposase
MFHKENPDYNRNQVGFYSLDELVPKDHLLRQIDEAIDFSFIYDLVKDSYCADNGRPSLDPVMLVKIPMIQCLFGIRSMRQTIKDIEVNVAYRWFLGLTLEDKVPHFTTYGKNYNRRFQDKQVIEAIFAYILGLCLNAGLIDPTDIFVDGTHIKAAANNHKYINQEVDAQAKFMSDQLEKEIAKDREKHGKKSLGIAKEKEPISKKISTTDPDSGWFHKGEHKQVFAYNAQVACDKYGWALGYSIHAGNVHDSQAFPELFDKIKALTPHYLIADSGYKTPSIAHYLLTIGIIPVFSYTRPRSKKGMLRLKDFIYDEYYDVYLCPENHPLSYSTTTRDGYREYKSNPAVCQSCPLLSVCTQSKNHQKVITRHLWKDDLEVCEDIRHQRGMKERYQQRKETIERLFGTAKEYHNLRYTRLRGKSKMEATLGLTLACLNMKKYSKIMAGIVFLVCLKVIISRPIVITIVKEKTSWINIPVCLQSE
>NZ_CP026082.1|WP_161501839.1|956520_956892_+|hypothetical-protein
MRLWHQDILPRQQLLGQHRECCALRGNGWGRKHETVDYVFRYSPYRLFAYHQLVMEEMMERGYRVSKEWLIAEYRGMKCPRYDTLNPVDLETPIYPEHNQDYLQECLWNLKAKGIDLPINKIK
>NZ_CP026082.1|WP_000438312.1|969445_969862_+|nucleoside-diphosphate-kinase
MEQTFFMIKPDGVKRGFIGEVISRIERRGFSIDRLEVRHADADILKRHYAELTDRPFFPTLVDYMTSGPVIIGVISGEEVISTWRTMMGSTNPKDALPGTIRGDFAQAPSPNQATCNIVHGSDSPESAAREIAIWFNN
>NZ_CP026082.1|WP_001019133.1|969997_971830_+|elongation-factor-4
MNIEDLKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSREMQAQLLDSMDLERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVRAEVEDVIGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGEVDAPLQALIFDSVYDAYRGVILQVRIVNGMVKPGDKIQMMSNGKTFDVTEVGIFTPKAVGRDFLATGDVGYIAASIKTVADTRVGDTITLANNPAIEPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQFEPETSQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVVYHVNTTDGEMLEVSNPSEFPDPTRVDSIEEPYVKAQIMVPQEFVGAVMELAQRKRGDFVTMDYIDDNRVNVIYQIPLAEIVFDFFDKLKSSTRGYASFDYEISEYRRSQLVKMDILLNGDKVDALSFIVHKEFAYERGKLIVDKLKKIIPRQQFEVPIQAAIGQKIVARSDIKALRKNVLAKCYGGDVSRKRKLLEKQKAGKKRMKAIGSVEVPQEAFLSVLSMDDDDKK
>NZ_CP026082.1|WP_161501841.1|972076_974710_+|pneumococcal-type-histidine-triad-protein
MKGQKIIALAGLVLSCHFALTACHTQEHKNSHHIKTKQVAKKKANKKKVSVKESHKKRKGVAGVDFPTDDGFLLTKDSKILSHTDSGIVVAHGNHSHFIFYSDLKGSKFSYLIPNANTKTNKNQAVRNFKAGAVAVNTLNDGYVFNPADIVSEDANGYVVRHGDHFHYIPKASLSQQKQVQASRAVSRLGNQSNSHYRVNSSKIAGLHYPTSNGFLFNGRGIKGTTPTGILVEHHNHLHFISFADLRKGGWGSIADRYQPQKKADSKKQSPSSKKPRTENTLPKDIKDKLAYLARELHLDISRIRVLKTLNGEIGFEYPHDDHTHVIMAKDIDLSKPIPNPHHDDEDHHKGHHHDESDHKHEEHEHTKSNKLSDEDQKKLIYLAEKLGLNPNQIEVLTSEDGSIIFKYPHDDHSHTIASKDIEIGKPIPDGHHDHSHAKDKVGMATLKQIGFDDEIIQDILHADAPTPFPSNETNPEKMRQWLATVTKINIGQRTNPFQRFGLSLMPNIEVLGIGFTPINDMTPVLQFKKLKQLWMTNTGITDYSFLDKMPLLEGLDISQNGIKDLSFLTKYKQLSLIAAANNGITSLKPLAELPNLQFLVLSHNNISDLTPLSNLTKLQELHLDHNNVKNLSALSGKKDLKVLDLSNNKSADLSTLKTTSLETLLLNETNTSNLSFLKQNPKVSNLTINNAKLASLDGIEESDEIVKVEAEGNQIKSLVLKNKQGSLKFLNVTNNQLTSLEGVNNYTSLETLSVSKNKLESLDIKTPNKTVTNLDFSHNNVSTSQLKLNEKNIPEAVAKNFPAVVEGSMVGNGSLAEKAAMASKEDKQVSDNTNHQKNTEKSAQANADSKKENPKTHDEHHDHEETDHAHVGHHHH
>NZ_CP026082.1|WP_001292556.1|974793_976071_-|group-II-intron-reverse-transcriptase/maturase
MSELLDKILSRNNMLEAYKQVKSNKGSAGIDGVTIEQMDDYLHQNWRETKQLIKERSYKPQPVLRVEIPKPNGGVRNLGIPTAMDRMIQQAIVQVLSPLCEKHFSEYSYGFRPNRSCETAIVQLLEYLNDGYEWIVDIDLEKFFDTVPQDRLMSLVHNIIQDGDTESLIRKYLHSGVVINGQRHKTLVGTPQGGNLSPLLSNIMLNELDKELEKRGLRFVRYADDCVITVGSEAAAKRVMHSVSSYIEKRLGLKVNMTKTKIVRPNKLKYLGFGFWKSPKGWKCRPHQDSVQSFKRKLKQLTMRKWSIDLITRIERLNWVIRGWINYFSLGNMKSIMTQIDERLRTRIRVIIWKQWKKKAKRLWGLLKLGVARWIADKVSGWGDHYQLVAQKSVLKRAISKPALAKRGLVSCLDYYLERHALKVS
>NZ_CP026082.1|WP_000180007.1|976666_977326_+|HD-domain-containing-protein
MTMVKREDVILNATENMVHHKLKNDPSGHDWFHIVRVRNLAVELAHKEGANTFICQMAALLHDIIDDKICQDSKQASYELTQWLYSQDLAIAEVEHILDILENISFKAGTGLTMKTLEGQIVQDADRLDAMGAIGIARTMAYSGSKGRLIHDPNLKPRENLTLEEYRNGQDTAIMHFYEKLLKLKDLMNTKQGKMLAQKRHDFLELYLAEFYAEWNGKR
>NZ_CP026082.1|WP_000621142.1|977334_977799_+|GNAT-family-N-acetyltransferase
MIRRAKEKDLPDIAELLKQILMLHHEVRPDIFHTRGSKFSKEQLKEMLIDESKPIFVYESDEGKVVAHLFLQLQEKRDLPRKSFKTLYIDDLCIDEEVRGQQIGQKLMDFARQYAKKHGCYNITLNVWNDNQRAVSFYEKLGFKPQQTQMEEIL
>NZ_CP026082.1|WP_000665410.1|977798_978233_+|peptide-methionine-(R)-S-oxide-reductase-MsrB
MKETQEELRQRIGHTAYQVTQNSATEHAFTGKYDDFFEEGIYVDIVSGEVLFSSLDKFQSGCGWPAFSKPIENRMVTNHQDHSHGMHRIEVRSRQADSHLGHVFNDGPVDAGGLRYCINSAALDFIPYDQMAKRGYGDYLSLFD
>NZ_CP026082.1|WP_000168905.1|978384_981177_+|cation-transporting-P-type-ATPase
MASTNNVSDTNTRFAKEELEEVFEELGTTQGGLSDEEVAVRQKKYGLNLLSEVKQESIILLFLKNFTSLMAILLWVGGFVAIVSNSLELGLAIWMVNVINGIFSFIQEYRASQATQALEKMLPSYSRVLRKSSEEKILSEQLVPGDIVLIEEGDRISADGRLIKTTDLQVNQSALTGESNPIYKDSNVENDQSKTLIECDNMVFAGTTVSSGSATMVVTAIGMQTQFGQIADLTQGMKSEKSPLQRELDRLTKQISIISITVGIIFFLAATFFVKEPVSKSFIFALGMIVAFIPEGLLPTVTLSLAMAVQRMAKEHALVKKLSSVETLGATSVICSDKTGTLTQNEMTVNHLWQNGKSYQVTGLGYAPEGQILFEGDNICFGNSDRGDLEKLIRFAHLCSNAQVLPPNDDRSTYTVLGDPTEACLNVLLEKSGINIQENRKFAPRLKELPFDSVRKRMTTIHSLGGDEKDKKISITKGAPKEILDLSDYVLSDGKVIPLNKEERNKIQLANDTFAKDGLRVLAVSYCDIEGFSKEQWTQENLEQHMVFIGLIAMSDPPREGVREAIDKCHAASIRIIMVTGDYGLTALSIAKNIGIIRNDDAKVISGLELSEMTDSQLKKELSGEVVFARVAPEQKYRVVTILQEMGEVVAVTGDGVNDAPALKKSDIGVAMGVTGTDVAKESADMILTDDHFASIVHAVEEGRAVYQNIKKFLTYIFNSNTPEAVPSAFFLFSKGFIPLPLTVMQILAVDLGTDMLPALGLGVEPPETDVMNRPPRRLTDRLLDKGLLIKSFLWYGTIESVLAMGGFFWAHYLRYGNFTFFVANGIPYREATTMTLGAIIFSQIGMVMNSRTSYQSIKALSIFGNKLINFGIIMEILAFLVLVYVPLFHNLFNTASLGLSHWLYLISCPFIMIGLDEVRKLFSSRKNKR
>NZ_CP026082.1|WP_000065321.1|981176_982280_+|DUF2974-domain-containing-protein
MSNIITYLKNNSNLTFDELALNDVDILCLNEFGYISFEKLINTTEMKSVLVCELYHEYLQTMAKSYSFMFTSQRHDLCQLMMTSKRFKNLTLSYYRAEISLEFEKQFAAMVFTIPNINYHQVVFRGTDANLIGWKEDFKLTYMREISAHRSAIKYLNTILPYFDKVVLSGHSKGGNLALYAAMFTKPDLKAKIDLIWLIDSPGLQKTLLPTTEYKTTKQKCIRLLPEESIVGMMLYSDIEPLIISSNARGILQHDVTTWEIQEPAILKTGTGLSLKSICFEKTFQQWMAELKSQERKLFFDLLFDSFLSSGVSSLDDFNLASRAKMMKAFHSFRELDDDKKRLFNKSLKLLVTIFWGAYHDNSRETK
>NZ_CP026082.1|WP_000146565.1|982330_982969_-|CatB-related-O-acetyltransferase
MASILKKHLEKRLELKNDPMRTDMSTGASYPKYGFSVGKYTYGYQQFFYEGVNLKEIGAFCSIAQNVTITGLNHPTDHITTNPFIYYKSRGFINEDRADLIDEKKNGKVIIGNDVWIGTNVTILPSVTIGNGAIIGAGSVITKDIPDYAVVAGTPAKIIKYRFSEEEITLLNASQWWNWSDEAIKEHISEFSDKKEFFNTLKSISENKNHKL

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Crispr_ID: NZ_CP026082_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP026082_2

2111057-2111167

Orphan

Consensus_repeat	Method
GCTTCTTGAGCTTTCGTAACATCTGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP026082_2

>merge|NZ_CP026082|2|2111057-2111167|CRISPRCasFinder
GCTTCTTGAGCTTTCGTAACATCTGATCGTGCTTGATCCACACTAGTTTGATTTTCAGCAACAACTTGTGTTTAATTAGCAACTGCTTCTTGAGCCTTCGTAACATCTGAT

>NZ_CP026082|2|2|2111057-2111167|CRISPRCasFinder
GCTTCTTGAGCTTTCGTAACATCTGAT	CGTGCTTGATCCACACTAGTTTGATTTTCAGCAACAACTTGTGTTTAATTAGCAACT
GCTTCTTGAGCCTTCGTAACATCTGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP026082.1\|WP_017643577.1\|2112752_2113100_-\|nucleotidyltransferase	unknown	unknown	gnl\|CDD\|143393
NZ_CP026082.1\|WP_000078466.1\|2115683_2115878_-\|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin	unknown	unknown	gnl\|CDD\|274102
NZ_CP026082.1\|WP_161501960.1\|2118209_2119499_-\|YSIRK-type-signal-peptide-containing-protein	unknown	unknown	gnl\|CDD\|273479
NZ_CP026082.1\|WP_000279881.1\|2121568_2122237_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224059
NZ_CP026082.1\|WP_000457171.1\|2114062_2114416_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP026082.1\|WP_017643589.1\|2101024_2101507_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377800
NZ_CP026082.1\|WP_000726285.1\|2115324_2115681_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026082.1\|WP_001151272.1\|2105748_2106213_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026082.1\|WP_017643575.1\|2116934_2118032_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|366278
NZ_CP026082.1\|WP_017643588.1\|2101560_2101833_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026082.1\|WP_000354105.1\|2106212_2106527_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026082.1\|WP_000942712.1\|2100806_2101022_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026082.1\|WP_161501958.1\|2104016_2105726_-\|cell-division-protein-FtsK	unknown	unknown	gnl\|CDD\|224588
NZ_CP026082.1\|WP_017643578.1\|2112412_2112793_-\|DUF86-domain-containing-protein	unknown	unknown	gnl\|CDD\|225236
NZ_CP026082.1\|WP_047212155.1\|2102477_2103719_-\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367101
NZ_CP026082.1\|WP_017643579.1\|2111978_2112359_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026082.1\|WP_017643580.1\|2111591_2111960_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026082.1\|WP_017643586.1\|2102099_2102477_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026082.1\|WP_017643590.1\|2100330_2100810_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026082.1\|WP_161501959.1\|2106597_2109222_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|275068

Protein	Function_ID	Function_description	E-value
NZ_CP026082.1\|WP_017643577.1\|2112752_2113100_-\|nucleotidyltransferase	gnl\|CDD\|143393	cd05403, NT_KNTase_like, Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins. S. aureus KNTase is a plasmid encoded enzyme which confers resistance to a wide range of aminoglycoside antibiotics which have a 4'- or 4''-hydroxyl group in the equatorial position, such as kanamycin A. This enzyme transfers a nucleoside monophosphate group from a nucleotide (ATP,GTP, or UTP) to the 4'-hydroxyl group of kanamycin A. This enzyme is a homodimer, having two NT active sites. The nucleotide and antibiotic binding sites of each active site include residues from each monomer. Included in this subgroup is Escherichia coli AadA5 which confers resistance to the antibiotic spectinomycin and is a putative aminoglycoside-3'-adenylyltransferase. It is part of the aadA5 cassette of a class 1 integron. This subgroup also includes Haemophilus influenzae HI0073 which forms a 2:2 heterotetramer with an unrelated protein HI0074. Structurally HI0074 is related to the substrate-binding domain of S. aureus KNTase. The genes encoding HI0073 and HI0074 form an operon. Little is known about the substrate specificity or function of two-component NTs. The characterized members of this subgroup may not be representive of the function of this subgroup. This subgroup belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, co-ordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this subgroup.	2.5494e-10
NZ_CP026082.1\|WP_161501959.1\|2106597_2109222_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|275068	TIGR04228, isopep_sspB_C2, adhesin isopeptide-forming domain, sspB-C2 type. This domain has a conserved Lys (position 3 in seed alignment) and Asn at 177 that form an intramolecular isopeptide bond. The Asp (or Glu) at position 59.	2.45896e-60
NZ_CP026082.1\|WP_017643578.1\|2112412_2112793_-\|DUF86-domain-containing-protein	gnl\|CDD\|225236	COG2361, COG2361, Uncharacterized conserved protein [Function unknown].	2.00574e-12
NZ_CP026082.1\|WP_017643589.1\|2101024_2101507_-\|hypothetical-protein	gnl\|CDD\|377800	pfam07275, ArdA, Antirestriction protein (ArdA). This family consists of several bacterial antirestriction (ArdA) proteins. ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification.	7.60277e-12
NZ_CP026082.1\|WP_000457171.1\|2114062_2114416_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.13974e-17
NZ_CP026082.1\|WP_161501960.1\|2118209_2119499_-\|YSIRK-type-signal-peptide-containing-protein	gnl\|CDD\|273479	TIGR01168, M_protein_serotype, Gram-positive signal peptide, YSIRK family. Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology. There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus.	2.7426e-08
NZ_CP026082.1\|WP_047212155.1\|2102477_2103719_-\|XRE-family-transcriptional-regulator	gnl\|CDD\|367101	pfam02486, Rep_trans, Replication initiation factor. Plasmid replication is initiated by the replication initiation factor (REP). This family represents a probable topoisomerase that makes a sequence-specific single-stranded nick in the plasmid DNA at the origin of replication. Human proteins also belong to this family, including myelin transcription factor 2 and cerebrin-50.	1.25455e-59
NZ_CP026082.1\|WP_000279881.1\|2121568_2122237_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	5.97789e-97
NZ_CP026082.1\|WP_000078466.1\|2115683_2115878_-\|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin	gnl\|CDD\|274102	TIGR02384, Putative_antitoxin_RelB, addiction module antitoxin, RelB/DinJ family. Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all were found adjacent to toxin genes. The resulting model appears to describe a narrower set of proteins than pfam04221, although many in the scope of this model are not obviously paired with toxin proteins. Several toxin/antitoxin pairs may occur in a single species. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other].	5.37844e-11
NZ_CP026082.1\|WP_161501958.1\|2104016_2105726_-\|cell-division-protein-FtsK	gnl\|CDD\|224588	COG1674, FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning].	3.82406e-13
NZ_CP026082.1\|WP_017643575.1\|2116934_2118032_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|366278	pfam00746, Gram_pos_anchor, LPXTG cell wall anchor motif.	1.03698e-06

>NZ_CP026082.1|WP_161501959.1|2106597_2109222_-|LPXTG-cell-wall-anchor-domain-containing-protein
MRETKGHGFFRKSKAYGLVCGIAFAGVFAFNGGNVSADEVTAPAQPQTVVTTLTEPTNNQAQAVTSEALNTAVSTAKEAGVTVNTTGAVSHTDVPSAQSDLASQTQTVKDATAKAEANTQAIKDATAQNAQIDAQNQAEATRVAEANKAGQLAVDQKNAQGQALVDKQNADAQAQADATNAQLKADYEAKLAEIKTVEDYNKAVAERNALAKQQADATNAQAKAEYDRLLSIYNKALADRVNLVANDVTFEGYGKSEVLDSYGQKTTDVVTVNNDGTFVLTEPQSDTDGTFGNTKVTGEFIYTVSFDPATNQAVIKITGISLNTWQLDLTRQTTAVNRNISASYKDLAGNVLYTRHFDGLSSIGVQTINKSFALDKEIILSNAQTSEEVMFLKTVPSWIYEAPSSLYAKLSYNTNALPPKPQEPTLVTVTPEPLKPVPQTPPVPVYVKPVLKTFTPEVYTPIKPTVKPHVAVPDKLVVTVSVHPVVVPVANPSKDVVDQAGKSINGLSVLPNSDLNYVAKQDFSQYKGMTASNDKIAKNFIFIDDYKDEALDGKSMVVNSIKAKNGDDVSHLLEIRHVLSKDNLDAKIQAILAESGLSPVGEFYMWVAKSPESFFTAYVQKGLDITYNLSFKVNQTFTEGEIVNGVAQIDFGNGYLGNLVVNDLPKPEVHKDVLDKQDGKSINNGTVKLGDEVTYKLEGWVVPTGRSYDLFEYKFVDQLQNTHDLYLKDSVVAKVDITLSDGTVITKGSNLAQYTETVYNKETGRYELAFKKDFLTKIVRSSEFGADAILVVKRIKAGDVYNTTDLYVNGYKVKSETVVTHTPEDPKPVTPQKATPKTPALSHTGEASVAPLTAVGAIILSVLGLLGFKKRKEN
>NZ_CP026082.1|WP_000354105.1|2106212_2106527_-|hypothetical-protein
MDINTLKLDTKFIGQAYYEKLGNAPRQVAGEAGQFQRHVVSNEKHGVFHIITPALPNVFKTDDLVEISGEAIFYEDVALNGRNVAPALNVRATGLKLVQNGGNK
>NZ_CP026082.1|WP_001151272.1|2105748_2106213_-|hypothetical-protein
MAKVGLNFGEKMQIADKTYRVLNDGLVDLKEIFGDLSFRSFEESDLIYADDMTQPRRPDGTYPQIPTGESRGLVVGIFSSIQGQTEFFTLVDMTLADFEGLQLKYRDPVELEDIVVTYSSVGSNQFKLFASKIKKKGASGSVKENNQSQQPKKD
>NZ_CP026082.1|WP_161501958.1|2104016_2105726_-|cell-division-protein-FtsK
MARILPEYRGVKVKPYMRYMSYYLFSSLLILCVIPIIFYVYLNQDLLRMMDVMTLIIIGSSIIFSIFLCWYLTWYLQEATPLFKKLDRLKRLSKFLFENGFIYEKRKQNSKKSKVKVKFPKVFLKQGKYDLSVSFEMAGNKFQKRFKDIGGELEDTFFMDFMEKTDDPRFKIYKLAYSAYMSRITVNDVIWDKEKGIKLMDGYYWDFISDPHLLVAGGTGGGKTVLLRSIINCLAKIGVCDICDPKRADFVTMADLPAFEGRIAFEKADMIAKFENAVTIMFARYDFIRKEMKRLGHKDMKKFYDYGLEPYFFICDEFNAFISSLTYQEVDIVVPTLVQFILLGRQVGCNAIIAMQKPSADDLPTKIRSNMMQHISVGRLDDTGYHMMFGDENRNKEFRYIRYISGRRVYGRGYSAIFGDVAREFYSPLLPKNFSFYNAFEKIERHDNPFDPTENTEISTEILQDKELQEFVNKFSGNDDFIEEEDYDMEEYQKLSIGDLSRKIDVSFGKIKNLIDMIEKDGYKQFDREDEKVSLDEADCKILENLLTEKDKFEGSWKELLNIYFKGEK
>NZ_CP026082.1|WP_047212155.1|2102477_2103719_-|XRE-family-transcriptional-regulator
MNPMYLKKFRKKSGLKQKEFAECVGISQAMLSQYESGKKKLSLEKFQEMKTHFGYLTDNDSSRLQVTIDYVKITLKSVRDLEFFCRNFLHCRFKEFSSVESKLMNYNHIWKRGDIWIFDYADKHDTGNYQITLQLSGQGCRQLELLMEQENFSWLDWLIYLRRSYRDEMNVTRFDLAIDELYLSKDRENEQFHLSDMISKYYHHELAFESLRTWNYIGGGALNFNDMEEIEQNRQGISLYFGSRQSEMYFNFYEKRYELAKLEGISIEESLEIFEIWNRYEIRLSQSKANAVVDEFISGIPLGEIARGLINSKIQVYDGKNKYGAFMADQKWQIMFGGVEPLTFVTRPEAYNIERTIRWLIHQVSDSLAMVSEYDSMIDGDNLQMIINSGEVNERGEKVLETIRHNLGLDKGA
>NZ_CP026082.1|WP_017643586.1|2102099_2102477_-|hypothetical-protein
MYKEDEFNYFVSTRNNLELIIDTLVLMIPDREFYYPEIQTGELRNYQKDIYDLIKIGYVGVSDIEKDYDNKLRELVNFKRKLLKFGLLMQPLDRQKEIVMNLASQYRLHKRLLKQRENFRGDERD
>NZ_CP026082.1|WP_017643588.1|2101560_2101833_-|hypothetical-protein
MSGTRSEADKKLLQVAQELSELLVGHSYDQAWEKAGELNSILKKREEFTLPEYMVDMIQQHLKSYYRQNKIVNKAHIAMSAIGHKLQEFH
>NZ_CP026082.1|WP_017643589.1|2101024_2101507_-|hypothetical-protein
MDISAIVRDIKTGRATLVCFPVEMNELKLALGLREEDDLEYIIVDSSCPMVKEYDSINTINDFVKKVEDVDDVIVLAVHEVTGYNIKDVIDYDFDFTVCSLLPDVNTRRELGEYWFNELGSEGIGKENIETYFDYQAFGCDIAIESEGGFTSHGYLEIGG
>NZ_CP026082.1|WP_000942712.1|2100806_2101022_-|hypothetical-protein
MLRAYIINPINNKGSWFDFPLYFGKLKKIGHSGSYDELVDIVSFEGNSTLRLGYYNLHELERLNAGIEGRL
>NZ_CP026082.1|WP_017643590.1|2100330_2100810_-|hypothetical-protein
MIAIIRTREGGRSKALCELDIMKFTKSQVRNRMEERGVNDDTFFIVGFSDWGIDRIMSLNECYLLKKCINELYDGDDYVVRFLLLKGHSVFKIVSQYYQYISKDEIEVMRYLLKTADFDSVIEFWFKTKTWLNAVEVYIENGVLLNTEKGFYVRKLEGG
>NZ_CP026082.1|WP_017643580.1|2111591_2111960_-|hypothetical-protein
MKYKEGVRLCKEKTNESEIEERTIKVIKKTMYVESKGFFTDYYYGIAIYEKGKEIYRPIYPFVRSRNDLENLKKFVKEYENDLLEFYKFGHNYDFGKFIYGIGSGGKDRMREQWFKLGVVFY
>NZ_CP026082.1|WP_017643579.1|2111978_2112359_-|hypothetical-protein
MKKIIGYVLLILVSLFLFSINLNYDSFPSEKDYISRNSKEKRINLVFYKKGCRYCEASKDEIIEEAKDSNIVTYFIDAGKEEGIVIAKKYHVKYASTIVTIRNNDYKSFLYAYDRNKKIVIEKDNI
>NZ_CP026082.1|WP_017643578.1|2112412_2112793_-|DUF86-domain-containing-protein
MRQDQLERDYYFLKQMIYYCEQTFARIEFAKKSQLSINDEMVIDSLAMNLGQIGEQLDSSKLSEELREQYSDIPWRKIKDFRNLAYHNYGAIRIQVLLRIIENELPILLNQLSSVLKDIERKLSDC
>NZ_CP026082.1|WP_017643577.1|2112752_2113100_-|nucleotidyltransferase
MVYTIDEIKEKIQPIAEKYELPVVYLFGSYARQEADDDSDIDIAVSVEDLAITGFELLDLEDEIKNSFSVPVDFLVIEDIEVGKSPIAIQVKKNFENEKVKLYEARSVRERLLLS
>NZ_CP026082.1|WP_000457171.1|2114062_2114416_+|helix-turn-helix-transcriptional-regulator
MFAERLKELRKDRGFTNQTSIAKDLGISQQTYSQWESGKREPSKSTLEKLADFFNVSTDYLLGKTNNKDIRKNELEQAEFLFRTTVSELKLNEKEKTQLKKDIENFIEQRKKVFKEK
>NZ_CP026082.1|WP_000726285.1|2115324_2115681_-|hypothetical-protein
MKKKFLGLLVFTLSTIFLVACSNNSLDGEYYWINDARNQHMATIKGDKGYVESEGGYSIKIDSELEIIESKFGSAKYSYQNGKLTTNFTGVESDFYKKGSKACDEALKKYGYKEVGKE
>NZ_CP026082.1|WP_000078466.1|2115683_2115878_-|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin
MSQIVVRVDDRLKDESSLLFKSLGLDMSTAIKMFLIQSVKTQSIPFEIKNNPSILVDELENKEF
>NZ_CP026082.1|WP_017643575.1|2116934_2118032_-|LPXTG-cell-wall-anchor-domain-containing-protein
MQWNGTLGQRHRHINSDYLYVSPLIDGYGIWSDAFQQNLFQDAQDTLTSVLASTNISSVDFALMQPQARHDILVYDSLDNLAHPGNVAQSETTGLLPNTAYKIQWFQDGVTLGQPVDVVSDEQGRIIIQDGTSITVPVDLQQDTVYTSAVFLATQDTSDFNGAIAIDSFTAVIAIDPLTATATPVTVPEGQAVPSDTKVVETNKSDAVISSTPTNGLSVDENGNLVGTPTVDDWGTDEETREVKVPVKVTNTLPDGTEEVVEVEVPVTVNRDTDGDGIIDSEDPDDDNDGVEDGSDETPKAFTDFTATATPVTVPEGQAVPSDTKVNTLPLTGDSSEAFFTSAALAIISSVGLLGIAKGKKNGSD
>NZ_CP026082.1|WP_161501960.1|2118209_2119499_-|YSIRK-type-signal-peptide-containing-protein
MFRGDKRNVDFSEAKQRFSIKKFKFGAASVLIGLAFLGPFTQKVLAEEPVTTEPVSVDMVTNEPVTTEPVSVDMVTNEPVTTKPVSVEKVINEPVTTEPVSVDMVTNEPVTTKPVSVEKVINEPVTTEPISVDPVVLERTSIDGANMLRATVDSGTSGLTDTSIPPFDIENAIYVPGDSSKKQTYSGKAFIYESGNLSDNGNQQPVVGMEVYLQWVNGKGFVSPVFKTITDENGLYVFDLSQPITDELGNDYSFVLAGDSKFVIRTWAKNIDSEKYDVIQHGDKFYGYHNRIDRKNESWDFTAGVNKIVNGIIILQEKMMAEDWLSKTNDESQMSPNPDGIWPDRGIYGTVRGNVWYEGSEGAGTLADEYLFGGVGGSGDIAAQGVKVQASYVNDEVARRFDTWKTEHPGYTLEDFKVAQAQIISEYEQ
>NZ_CP026082.1|WP_000279881.1|2121568_2122237_-|ABC-transporter-ATP-binding-protein
MAVLTFKEVTKSFKDGRQEVQALKATNFTIKSGEFVAIVGPSGSGKSTFLTIAGGLQTPTSGQLTIDGKDYTNLSEKERSRLRFESVGFILQASNLIPFLTVKQQLELVDKLAGNHIPDKANALFEDLGIVALQNKLPQELSGGERQRVAIARALYPDPVLILADEPTASLDTKKAYDVVKLLAKESKEKNKAIIMVTHDDRMTDFCDKIYHMQDGILSQKR

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Crispr_ID: NZ_CP026082_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP026082_3

2154356-2154781

Orphan

Consensus_repeat	Method
TTCTGGNTTNGCNTCTGG	CRT

8 spacers

The CRISPR arrays of NZ_CP026082_3

>merge|NZ_CP026082|3|2154356-2154781|CRT
TGCTGGTTTGGCTTCTGGTTTAGCCTCTGGCTTAACGTCTGGTTTAACTTCTGGTTTAACTTCTGGTTTGGCTTCTGGTTTAACTTCTGGTTTGGCTTCTGGTTTAGCTTCTGGCTTAGCTTCTGGTTTGGCCTCTGGCTTAACGTCTGGTTTAACTTCTGGCTTAGCCTCTGGTTTGGCTTCTGGTTTAGCCTCTGGTTTGGCCTCTGGCTTAACGTCTGGTTTAACTTCTGGTTTAACTTCTGGTTTGGCTTCTGGTTTAGCTTCTGGCTTAGCTTCTGGCTTAGCTTCTGGTTTGGCCTCTGGCTTAACGTCTGGTTTAACTTCTGGCTTAGCTTCTGGCTTAGCCTCTGGTTTAGCTTCTGGCTTAGCCTCTGGTTTGGCCTCTGGCTTAGCCTCTGGTTTGGCCTCTGGCTTAACTTCTGG

>NZ_CP026082|3|2|2154356-2154781|CRT
TGCTGGTTTGGCTTCTGG	TTTAGCCTCTGGCTTAACGTCTGGTTTAACTTCTGGTTTAAC
TTCTGGTTTGGCTTCTGG	TTTAACTTCTGGTTTGGCTTCTGGTTTAGCTTCTGGCTTAGC
TTCTGGTTTGGCCTCTGG	CTTAACGTCTGGTTTAACTTCTGGCTTAGCCTCTGGTTTGGC
TTCTGGTTTAGCCTCTGG	TTTGGCCTCTGGCTTAACGTCTGGTTTAAC
TTCTGGTTTAACTTCTGG	TTTGGCTTCTGGTTTAGCTTCTGGCTTAGC
TTCTGGCTTAGCTTCTGG	TTTGGCCTCTGGCTTAACGTCTGGTTTAAC
TTCTGGCTTAGCTTCTGG	CTTAGCCTCTGGTTTAGC
TTCTGGCTTAGCCTCTGG	TTTGGCCTCTGGCTTAGCCTCTGGTTTGGC
CTCTGGCTTAACTTCTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP026082.1\|WP_161501962.1\|2136543_2138781_-\|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|235367
NZ_CP026082.1\|WP_000145170.1\|2148275_2150777_-\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234743
NZ_CP026082.1\|WP_000010476.1\|2158912_2159797_+\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NZ_CP026082.1\|WP_000953619.1\|2152443_2153289_-\|patatin-family-protein	unknown	unknown	gnl\|CDD\|132847
NZ_CP026082.1\|WP_000057521.1\|2156346_2156499_-\|50S-ribosomal-protein-L33	unknown	unknown	gnl\|CDD\|234783
NZ_CP026082.1\|WP_161501965.1\|2156547_2158869_-\|PBP1A-family-penicillin-binding-protein	unknown	unknown	gnl\|CDD\|223815
NZ_CP026082.1\|WP_000903267.1\|2147577_2148186_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026082.1\|WP_161501964.1\|2153426_2153966_-\|transcription-termination/antitermination-protein-NusG	unknown	unknown	gnl\|CDD\|180161
NZ_CP026082.1\|WP_001182060.1\|2164833_2165613_-\|uridine-phosphorylase	unknown	unknown	gnl\|CDD\|350167
NZ_CP026082.1\|WP_161501963.1\|2146096_2147485_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP026082.1\|WP_000074731.1\|2151153_2152401_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340929
NZ_CP026082.1\|WP_000459245.1\|2159821_2161462_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226987
NZ_CP026082.1\|WP_000453154.1\|2162909_2163581_-\|deoxyribose-phosphate-aldolase	unknown	unknown	gnl\|CDD\|234784
NZ_CP026082.1\|WP_000161339.1\|2145413_2146100_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP026082.1\|WP_000610953.1\|2139150_2139474_-\|AzlD-domain-containing-protein	unknown	unknown	gnl\|CDD\|226827
NZ_CP026082.1\|WP_001159688.1\|2163610_2164813_-\|NupC/NupG-family-nucleoside-CNT-transporter	unknown	unknown	gnl\|CDD\|224883
NZ_CP026082.1\|WP_001125582.1\|2165770_2166508_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NZ_CP026082.1\|WP_032455265.1\|2156137_2156314_-\|preprotein-translocase-subunit-SecE	unknown	unknown	gnl\|CDD\|223762
NZ_CP026082.1\|WP_001093381.1\|2140468_2145181_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173801
NZ_CP026082.1\|WP_000077187.1\|2161631_2162843_-\|phosphopentomutase	unknown	unknown	gnl\|CDD\|235430

Protein	Function_ID	Function_description	E-value
NZ_CP026082.1\|WP_161501962.1\|2136543_2138781_-\|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase	gnl\|CDD\|235367	PRK05222, PRK05222, 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional.	0
NZ_CP026082.1\|WP_000145170.1\|2148275_2150777_-\|leucine--tRNA-ligase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0
NZ_CP026082.1\|WP_000010476.1\|2158912_2159797_+\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	7.14066e-85
NZ_CP026082.1\|WP_001125582.1\|2165770_2166508_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	6.94122e-33
NZ_CP026082.1\|WP_000610953.1\|2139150_2139474_-\|AzlD-domain-containing-protein	gnl\|CDD\|226827	COG4392, COG4392, Predicted membrane protein [Function unknown].	1.54249e-14
NZ_CP026082.1\|WP_161501965.1\|2156547_2158869_-\|PBP1A-family-penicillin-binding-protein	gnl\|CDD\|223815	COG0744, MrcB, Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane].	0
NZ_CP026082.1\|WP_161501963.1\|2146096_2147485_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.31083e-45
NZ_CP026082.1\|WP_000077187.1\|2161631_2162843_-\|phosphopentomutase	gnl\|CDD\|235430	PRK05362, PRK05362, phosphopentomutase; Provisional.	0
NZ_CP026082.1\|WP_161501964.1\|2153426_2153966_-\|transcription-termination/antitermination-protein-NusG	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	2.12104e-83
NZ_CP026082.1\|WP_001182060.1\|2164833_2165613_-\|uridine-phosphorylase	gnl\|CDD\|350167	cd17767, UP_EcUdp-like, uridine phosphorylases similar to Escherichia coli Udp and related phosphorylases. Uridine phosphorylase (UP) is specific for pyrimidines, and is involved in pyrimidine salvage and in the maintenance of uridine homeostasis. In addition to E. coli Udp, this subfamily includes Shewanella oneidensis MR-1 UP and Plasmodium falciparum purine nucleoside phosphorylase (PfPNP). PfPNP is an outlier in terms of genetic distance from the other families of PNPs. PfPNP is catalytically active for inosine and guanosine, and in addition, has a weak UP activity. This subfamily belongs to the nucleoside phosphorylase-I (NP-I) family, whose members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	4.65794e-137
NZ_CP026082.1\|WP_000953619.1\|2152443_2153289_-\|patatin-family-protein	gnl\|CDD\|132847	cd07208, Pat_hypo_Ecoli_yjju_like, Hypothetical patatin similar to yjju protein of Escherichia coli. Patatin-like phospholipase similar to yjju protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins, and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.	6.09692e-121
NZ_CP026082.1\|WP_000074731.1\|2151153_2152401_+\|MFS-transporter	gnl\|CDD\|340929	cd17371, MFS_MucK, Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.90301e-69
NZ_CP026082.1\|WP_000459245.1\|2159821_2161462_-\|hypothetical-protein	gnl\|CDD\|226987	COG4640, COG4640, Predicted membrane protein [Function unknown].	3.0337e-08
NZ_CP026082.1\|WP_000453154.1\|2162909_2163581_-\|deoxyribose-phosphate-aldolase	gnl\|CDD\|234784	PRK00507, PRK00507, deoxyribose-phosphate aldolase; Provisional.	3.25832e-110
NZ_CP026082.1\|WP_000161339.1\|2145413_2146100_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.96096e-62
NZ_CP026082.1\|WP_000057521.1\|2156346_2156499_-\|50S-ribosomal-protein-L33	gnl\|CDD\|234783	PRK00504, rpmG, 50S ribosomal protein L33; Validated.	2.53308e-18
NZ_CP026082.1\|WP_001159688.1\|2163610_2164813_-\|NupC/NupG-family-nucleoside-CNT-transporter	gnl\|CDD\|224883	COG1972, NupC, Nucleoside permease [Nucleotide transport and metabolism].	3.49248e-155
NZ_CP026082.1\|WP_032455265.1\|2156137_2156314_-\|preprotein-translocase-subunit-SecE	gnl\|CDD\|223762	COG0690, SecE, Preprotein translocase subunit SecE [Intracellular trafficking and secretion].	2.76611e-09
NZ_CP026082.1\|WP_001093381.1\|2140468_2145181_+\|S8-family-serine-peptidase	gnl\|CDD\|173801	cd07475, Peptidases_S8_C5a_Peptidase, Peptidase S8 family domain in Streptococcal C5a peptidases. Streptococcal C5a peptidase (SCP), is a highly specific protease and adhesin/invasin. The subtilisin-like protease domain is located at the N-terminus and contains a protease-associated domain inserted into a loop. There are three fibronectin type III (Fn) domains at the C-terminus. SCP binds to integrins with the help of Arg-Gly-Asp motifs which are thought to stabilize conformational changes required for substrate binding. Peptidases S8 or Subtilases are a serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	6.9269e-90

>NZ_CP026082.1|WP_161501964.1|2153426_2153966_-|transcription-termination/antitermination-protein-NusG
MLDSFDKGWFVLQTYSGYENKVKENLLQRAQTYNMLDNILRVEIPTQTVNVEKNGKTKEIEENRFPGYVLVKMVMTDEAWFVVRNTPNVTGFVGSHGNRSKPTPLLEEEIRSILISMGQTVDVFDTNIKEGDVVQIIDGAFIGQEGRVVEIENNKVKLMINMFGSETQAELELYQVAEL
>NZ_CP026082.1|WP_000953619.1|2152443_2153289_-|patatin-family-protein
MLSVGLVLEGGGMIGLYTAGVLDAFLDAGIKIDGIVSVSAGALFGVNFVSRQRERALRYNKKYLSHPEYMSLRSWLRTGNFVNKDFTYYEVPMKLDVFDDEAFKKSSIDFYVVATEMTSGKPEYFKIDSVFEQMEILRASSALPVVSKMVDWQGKKYLDGGLSDSIPVDFARGLGFDKLIVVMTRPLNYQKKPSSGRLYKTLYRKYPNFVKTASNRYQQYNNSLEKVMSLEKTGDLFAIRPSKSLVIGRLEKNPDKLDSIYQLGMKDAKSMMPELNSYLMK
>NZ_CP026082.1|WP_000074731.1|2151153_2152401_+|MFS-transporter
MSPLNINKNNWRALIAAIVASGTDDLNIMFLAFSMSTIITDLHLSAAQAGWIGTITNLGMLVGGLIFGLLADRYNKFKVFKWTILIFSIATGLVFFTTNLSYLYIMRFIAGIGVGGEYGIAIAIMAGIVPANKMGRISSLNGIAGQVGSISSALLAGWLAPALGWRGLFLFGLLPIVLVLWMQFAIDDKDILDQYNTDADDEPLDISIKALFDTPVLATQSLALMVMTTVQIAGYFGMMNWLPTIIQTNLNVSVKNSSLWMIATILGMCLGMLVFGQLLDKFGPRLVYGCFLLSSAICVYLFQFATTMPSMIIGGAVVGFFVNGMFAGYGAMITRLYPHHIRSTANNLILNVGRAIGGFSSVIIGMILDVSNVSMVMLFLASLYIVSFLSMLSIKQLKRQKYHTNLTQLDVKPTD
>NZ_CP026082.1|WP_000145170.1|2148275_2150777_-|leucine--tRNA-ligase
MTFYNHKEIEPKWQAFWADNHTFKTGTDASKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRFKRAQGHNVLHPMGWDAFGLPAEQYAMDTGNDPAEFTAENIANFKRQINALGFSYDWDREVNTTAPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVEELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKDMQRNWIGKSTGANVTFKVKDTDKDFTVFTTRPDTLFGATYAVLAPEHALVDAITTADQAEAVAEYKRQASLKSDLARTDLAKEKTGVWTGAYAINPVNGKEIPVWIADYVLASYGTGAIMAVPAHDERDWEFAKQFKLDIIPVLEGGNVEEAAFTEDGLHINSDFLDGLDKAAAIAKMVEWLEVEGVGNEKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLVLPVTKDIRPSGTGESPLANLTDWLEVTREDGVKGRRETNTMPQWAGSSWYYLRYIDPHNTEKLADEELLKQWLPVDIYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPFQKLFNQGMILGTSYRDSRGALVATDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDVVEQYGADTLRVYEMFMGPLDASIAWSEEGLEGSRKFLDRVYRLITTKEITKENSGALDKVYNETVKAVTEQVDQMKFNTAIAQLMVFVNAANKEDKLFSDYAKGFVQLIAPFAPHLGEELWQVLTASGESISYVPWPSYDESKLVENEIEIVVQIKGKVKAKLVVAKDLSREELQELALANEKVQAEIAGKDIIKVIAVPNKLVNIVVK
>NZ_CP026082.1|WP_000903267.1|2147577_2148186_+|hypothetical-protein
MLHSKKIHSLSLIAVLSLATYTSLQPNHVTAEQSQKTSTVHMSQKTIEHKLKVADKEAAPLYAKIDHIQRHIEVKKAKDLKVIELYINKDIKQLEKQNKRLLTKFYTSIDNQTWDSTSEVKKLIDKTNLSTNEKDRLKLYFEQRAYLETRLNDRYQKFDNSIENQNKELKILTSKIEKIYQKHGITKEVLKTYYAKKTVRAD
>NZ_CP026082.1|WP_161501963.1|2146096_2147485_+|HAMP-domain-containing-histidine-kinase
MKKKSLISNLILINSITLFLGFYLIYFSVNYVIKDYVHQMTRNSMQANFTILDSIYNNKKIPDENMVNQDSIFVWSYYAIFDQHYRMKYGTDNHKKESHDIIRYLTQKRLWQISKEKDGMFVTIKKKTYYVMTKDYSGILVDGSIKKVPKAQSQLFHVINFSDITYTQHLITKINHFLIVILVLTYIPMLFIMKKTFTGIRESIQSVQTYISSLWKNQGNHQSSQKEIVFSDFDPLLLESQEMANRIYQAEESQRNFFQNASHELRTPLMSIQGYTEGVQEGIIDAELAHSVILQESKKMKQLVDDIILLSKLDSNLSNQKDEFSLNELLNSIIAYFKPLANKQKISITYRPDKHEKLLKGNEELIQRAINNILSNALRYAVSHIKISYTNQKLTISNDGPAISKEDLPYIFDRFYKGHGGQTGIGLAMTKEIIKQHHGNIIAESDSTSTTFTIYFNCHKIA
>NZ_CP026082.1|WP_000161339.1|2145413_2146100_+|response-regulator-transcription-factor
MTKIIYFADDEKNIRDLVVPFLEHDGFTVRAFETGDLLLEAYKNQKPDLVILDIMMPGTNGLDVMKSIRQYDNIPIIMLTARDSDVDFITAFNLGTDDYFTKPFSPIKLSLHVKALFKRLDEKAIKNNTQYQFLDLILDTEKRIALLSNEEMPLTKTEFDFLLVLIEKPETAFSRETLLNRIWGFDDIESRAVDDTIKRLRKKFKQYHSQVSIKTVWGYGFKLIKEDK
>NZ_CP026082.1|WP_001093381.1|2140468_2145181_+|S8-family-serine-peptidase
MNTKQRFSIRKYKLGAVSVLLGTLFFLGGITNVAADSVINKPSDIAVEQQVKDSPTSIANETPTNNTSSALASTAQDNLVTKANNSPTETQPVAESHSQATETFSPAANQPVESTQEVSKTPLTKQNLAVKPTPAISKETPQNIDSNKIITVPKVWNTGYKGEGTVVAIIDSGLDINHDALQLNDSTKAKYQNEQQMNAAKAKAGINYGKWYNNKVIFGHNYVDVNTELKEVKSTSHGMHVTSIATANPSKKDTNELIYGVAPEAQVMFMRVFSDEKRGTGPALYVKAIEDAVKLGADSINLSLGGANGSLVNADDRLIKALEMARLAGVSVVIAAGNDGTFGSGASKPSALYPDYGLVGSPSTAREAISVASYNNTTLVNKVFNIIGLENNKNLNNGLAAYADPKVSDKTFEVGKQYDYVFVGKGNDNDYKDKTLNGKIALIERGDITFTKKVVNAINHGAVGAIIFNNKAGEANLTMSLDPEASAIPAIFTQKEFGDVLAKNNYKIVFNNIKNKQANPNAGVLSDFSSWGLTADGQLKPDLSAPGGSIYAAINDNEYDMMSGTSMASPHVTGATALVKQYLLKEHPELKKGDIERTVKYLLMSTAKAHLNKDTGAYTSPRQQGAGIIDVAAAVQTGLYLTGGENNYGSVTLGNIKDKISFDVTVHNINKVAKDLHYTTYLNTDQVKDGFVTLAPQQLGTFTGKTIRIEPGQTQTITIDIDVSKYHDMLKKVMPNGYFLEGYVRFTDPVDGGEVLSIPYVGFKGEFQNLEVLEKSIYKLVANKEKGFYFQPKQTNEVPGSEDYTALMTTSSEPIYSTDGTSPIQLKALGSYKSIDGKWILQLDQKGQPHLAISPNDDQNQDAVAVKGVFLRNFNNLRAKVYRADDVNLQKPLWVSAPQEGDKNYYSGNTENPKSTFLYDTEWKGTTTDGIPLEDGKYKYVLTYYSDVPGSKPQQMVFDITLDRQAPTLTTATYDKDRRIFKARPAVEHGESGIFREQVFYLKKDKDGHYNSVLRQKGEDGILVEDNKVFIKQEKDGSFILPKEVNDFSHVYYTVEDYAGNLVSAKLEDLINIGNKNGLVNVKVFSPELNSNVDIDFSYSVKDDKGNVIKKQHHGKDLNLLKLPFGTYTFDLFLYDEERANLISPKSVTVTISEKDSLKDVLFKVNLLKKAALLVEFDKLLPKGATVQLVTKTNTVVDLPKATYSPTDYGKNIPVGDYRLNVTLPSGYSTLENLDDLLVSVKEGQVNLTKLTLINKAPLINALAEQTDIITQPVFYNAGTHLKNNYLANLEKAQTLIKNKVEQTSIDNAIAALRESRQALNGKETDTSLLAKAILAETEIKGNYQFVNASPLSQSTYINQVQLAKNLLQKPNVTQSEVDKALENLDIAKNQLNGHETDYSGLHHMIIKANVLKQTSSKYQNASQFAKENYNNLIKKAELLLSNRQATQAQVEELLNQIKATEQELDGRDRVSSAENYSQSLNDNDSLNTTPINPPNQPQALIFKKGMTKESEVAQKRALGVTSQTDNQKVKTNKLPKTGESTPKITYTILLFSLSMLGLATIKLKSIKRE
>NZ_CP026082.1|WP_000610953.1|2139150_2139474_-|AzlD-domain-containing-protein
MINSTVFLAILLGFVVSWVPRVAPFIFVKYKGLPNSLVKFLKFLPLSILFALTFSSFFSVKLGQLPTLKWLDLLAGIPTLVVTIRYRNLFYTVLTGIVTMALLRLLF
>NZ_CP026082.1|WP_161501962.1|2136543_2138781_-|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase
MVKVSNLGYPRLGEQREWKQAIEAFWAGNLEQKDLEKQLKQLRINHLKKQKETGIDLIPVGDFSCYDHVLDLSFQFNIIPKRFDEYERNLDLYFAIARGDKDNVASSMKKWFNTNYHYIVPEWEVETKPHLQNNYLLDLYLEAREVVGDKAKPVITGPITYVSLSSGIVDFEATVQRLLPLYKQVFQDLIDAGATYIQIDEPIFVTDEGELLVDIAKSVYDFFAREVPQAHFIFQTYFESAVCLDKLSKLPVTGFGLDFIHGRAENLAAVKQGLFREKELFAGIVNGRNIWAVNLEETLALLEEIGPFVKRLTLQPSSSLLHVPVTTKYETHLDPVLKNGLSFADEKLKELELLASALDGNKTKGYHEALSRFSALQAADFRHVALESLAEVRLERSPYKLRQALQAEKLQLPILPTTTIGSFPQSPEIRKKRLAWKRGNLSDSDYKDFIKTEIRRWIAIQEDLDLDVLVHGEFERVDMVEFFGQKLAGFTTTKLGWVQSYGSRAVKPPIIYGDVKHIQPLSLEETVYAQSLTKKPVKGMLTGPITITNWSFERDDISRSDLFNQIALAIKDEIQLLEQSGIAIIQVDEAALREGLPLRQQKQQAYLDDAVAAFKIATSSVKDETQIHTHMCYSKFDEIIDSIRALDADVISIETSRSHGDIIESFETAVYPLGIGLGVYDIHSPRIPTKEEIIVNIQRSLKCLSKEQFWVTPDCGLKTRREAETIAALEVLVSATKEVRQQLDN
>NZ_CP026082.1|WP_032455265.1|2156137_2156314_-|preprotein-translocase-subunit-SecE
MMFVKGIFQVLRDTTWPNRKQRWKDFISILEYTVFFTIVIYIFDKLLAAGVMDLINRF
>NZ_CP026082.1|WP_000057521.1|2156346_2156499_-|50S-ribosomal-protein-L33
MAQKKASLACTECGSRNYSIGVSSTPKPTRLEVNKFCKYCKKYTIHKETR
>NZ_CP026082.1|WP_161501965.1|2156547_2158869_-|PBP1A-family-penicillin-binding-protein
MKLFDKFIDLFRVDEDNDEMTRKNEQETREETSNLDGEEVYDIDDITRPSKSQYQRGIRHQKENAKSRPEWLQKVDRYLPSPKNPIRRFWRRYRIGKLLFIALMAFILIFGSYLFYLSKTATVSDLQSALKTTTTIYDKNKEYAGKLSGQKGTYVELNAISDNLKNAVIATEDRTFYENNGVNFKRFFLAVATLGKFGGGSTITQQLAKNAYLSQDQTIKRKAREFFLALELTKKYSKAEILTMYLNNSYFGNGVWGVEDASRKYFGTSAANLTVDEAATLAGMLKGPEVYNPYYSVENATNRRDTVLAAMVDAGKLTKSQAKEAASIGMKNRLADTYAGKINDYRYPSYFDAVVNEAIDTYGISEKDIVNNGYKIYTALDQNYQSGMQKTFDDTSLFPVSDYDGQSAQGASVALDPKTGGVRGLVGRVQSTKDAQFRSFNYATQSKRSPASTIKPLVVYSPAIASGWSIDKELPNKVQDFHGYKPSNYGGIETESIPMYQALANSYNIPAVYTLDKLGINKAFTYGRKFGLNMSSANKELGVALGGSVTTNPLEMAQAYSTFANDGIMHRAHLITRIETANGKLVKQFTDKPKRVISRSVASKMTSMMLGTFSNGTAINANVYGYTMAGKTGTTETDFNPNLSGDQWVVGYTPDVVISQWVGFKNTDKHHYLTDSSAGTASNIFSTQASYILPYTKGSSFTHIENAYFQNGIGSVYNAQDASNTTNQESRSIINDLKDSASKAAQDISRAVEDSNFQEKVKDAWNSLKDYFR
>NZ_CP026082.1|WP_000010476.1|2158912_2159797_+|RluA-family-pseudouridine-synthase
MSFSLKIRNPYGEHTVKELLEDYFLIPRKIRHFLRVKKHVLINNEFINWQTVVQENDTITLIFDDEDYPTKKIPLGRAELIDCLYEDEHLIIVNKPEGMKTHGNQPNEIALLNHVSAYSGQTCYVVHRLDMETSGAVLFAKNPFILPLINQRLERKEIWREYWALVEGKFSPKHQVLRDKIGRNRHDRRKRIIDSKNGQHAMTIIDVLKYIQNSSLIKCRLETGRTHQIRVHLSHHGHPLIGDPLYNPSSNNERLMLHAHRLTLSHPLTCETISVEAPSSTFEKILNNYKKGVG
>NZ_CP026082.1|WP_000459245.1|2159821_2161462_-|hypothetical-protein
MFDFFKKKVVKVCLVIFGIVLVSLLSLGFFYFSKGQVLSRFVAARSRTSGQAFDNIKEYMVWSDTGESITNDEANYANFEPLSKSEARKLGQEIKEGNKNDSMYLKRVGSRLGIFPDYRIANKPMSLTLKTNVPKLDVLLNQKKVATSNSDHFSVTVERLPRTHYTASLEGTSDGKEIKLKKDYDGKNQTIDLSVAFKSFTVTSNLMDGNLYFGDNRIAKLKDGSYSVENYPVTDGSKAYIKKVFNDGEITSHKQKLISIADNQTIKLDVDGLLNEKEAGQKLITAFNQLILYVSTGQDPQTLGTVFEKGGENDFYKGLKESIKAKFVTDNRKASHFTIPNIVLNKMTQVGKESYQVNFAADYDFNYDKSTDPDKKTYGHIIQNLTGNFIMKKSGNSYLISNDGKKDITVAKETNKVKADPVSIFPENLVGSWKGEVEDGTVTMTFDKDGKVTQKKVYKDSKSKESNHSAKVTKLEDKGNGLYLYQYESGTDTTTFVTGGIGGLKVKYAYGIKIEGNKIIPVIWQTSSDGEFDYHKPLLSKPLTKQ
>NZ_CP026082.1|WP_000077187.1|2161631_2162843_-|phosphopentomutase
MSQFDRIHLVVLDSVGIGAAPDANDFVNAGVPDGASDTLGHISKTVGLAVPNMAKIGLGNIPRPQALKTVPAEENPSGYATKLQEVSLGKDTMTGHWEIMGLNITEPFDTFWNGFPEDIITKIEDFSGRKVIREANKPYSGTAVIDDFGPRQMETGELIIYTSADPVLQIAAHEDIIPLEELYRICEYARSITMERPALLGRIIARPYVGEPGNFTRTANRHDYAVSPFEDTVLNKLDQAGIDTYAVGKINDIFNGSGINHDMGHNKSNSHGIDTLIKTMGLSEFEKGFSFTNLVDFDALYGHRRDPHGYRDCLHEFDERLPEIISAMRDKDLLLITADHGNDPTYAGTDHTREYIPLLAYSPSFTGNGLIPVGHFADISATVADNFGVDTAMIGESFLQDLV
>NZ_CP026082.1|WP_000453154.1|2162909_2163581_-|deoxyribose-phosphate-aldolase
MEVKDILKTVDHTLLATTATWPEIQTILDDAMAYETASACIPASYVKKAAEYVSGKLAICTVIGFPNGYSTTAAKVFECQDAIKNGADEIDMVINLTDVKNGDFDTVEEEIRQIKAACQDHILKVIVETCQLTKEELIELCGVVTRSGADFIKTSTGFSTAGATFEDVEVMAKYVGEGVKIKAAGGISSLEDAEKFIALGASRLGTSRIIKIVKNQKVEEGTY
>NZ_CP026082.1|WP_001159688.1|2163610_2164813_-|NupC/NupG-family-nucleoside-CNT-transporter
MQFIYSIIGILLVLGIVYAISFNRKSVSLSLIGKALIVQFIIALILVRIPLGQQVVSVVSTGVTKVINCGQAGLNFVFGSLADSGAKTGFIFAIQTLGNIVFLSALVSLLYYVGILGFVVKWIGKGVGKIMKSSEVESFVAVANMFLGQTDSPILVSKYLGRMTDSEIMVVLVSGMGSMSVSILGGYIALGIPMEYLLIASTMVPIGSILIAKILLPQTEPVQKIDDIKMDNKGNNANVIDAIAEGASTGAQMAFSIGASLIAFVGLVSLINMMLSGLGIRLEQIFSYVFAPFGFLMGFDHKNILLEGNLLGSKLILNEFVSFQQLGHLIKSLDYRTALVATISLCGFANLSSLGICVSGIAVLCPEKRGTLARLVFRAMIGGIAVSMLSAFIVGIVTLF
>NZ_CP026082.1|WP_001182060.1|2164833_2165613_-|uridine-phosphorylase
MQNYSGEVGLQYHLQIRPGDVGRYVIMPGDPKRCAKIAEHFDNAVLVADSREYVTYTGTLNGEKVSVTSTGIGGPSASIAMEELKLCGADTFIRVGTCGGIDLDVKGGDIVIATGAIRMEGTSKEYAPIEFPAVADLEVTNALVNAAKKLGYTSHAGVVQCKDAFYGQHEPERMPVSYELLNKWEAWKRLGTKASEMESAALFVAASHLGVRCGSDFLVVGNQERNALGMDNPMAHDTEAAIQVAVEALRTLIENDKSQ
>NZ_CP026082.1|WP_001125582.1|2165770_2166508_+|GntR-family-transcriptional-regulator
MPKNELNNKLNKLKHVQVYNKIFNMIQDGTYSPGMQLPSEPELAGQLNVSRATLRKSLALLQEDHLVKNIRGKGNFIRENSSNLSENGYENRQHPIKTCLTSKITEVELEFRVEVPAEAITASLKQETPVVVIADRWYHTDDGPLAYTLSFIPIELISDAEISLHDTKQLLNFIEEGIYQEGISSHSQSHLGYATSGNFSATKYTLSDHGQFILIQETIFNQEKILMCNKHYVPIEHFELSITSH

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP026082_3	3.4\|2154554\|30\|NZ_CP026082\|CRT	2154554-2154583	30	NZ_CP026082.1	2154758-2154787	2	0.933
NZ_CP026082_3	3.6\|2154650\|30\|NZ_CP026082\|CRT	2154650-2154679	30	NZ_CP026082.1	2154758-2154787	2	0.933

1. spacer 3.4|2154554|30|NZ_CP026082|CRT matches to position: 2154758-2154787, mismatch: 2, identity: 0.933

tttggcctctggcttaacgtctggtttaac	CRISPR spacer
tttggcctctggcttaacttctggcttaac	Protospacer
****************** *****.*****

2. spacer 3.6|2154650|30|NZ_CP026082|CRT matches to position: 2154758-2154787, mismatch: 2, identity: 0.933

tttggcctctggcttaacgtctggtttaac	CRISPR spacer
tttggcctctggcttaacttctggcttaac	Protospacer
****************** *****.*****

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP026082_1	1.2\|968382\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968382-968411	30	MK448755	Streptococcus phage Javan423, complete genome	6137-6166	0	1.0
NZ_CP026082_1	1.2\|968382\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968382-968411	30	MK448829	Streptococcus phage Javan7, complete genome	7029-7058	0	1.0
NZ_CP026082_1	1.2\|968382\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968382-968411	30	MH853355	Streptococcus phage LF1, complete genome	35307-35336	0	1.0
NZ_CP026082_1	1.2\|968382\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968382-968411	30	MK448970	Streptococcus phage Javan516, complete genome	10680-10709	0	1.0
NZ_CP026082_1	1.2\|968382\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968382-968411	30	MK448756	Streptococcus phage Javan425, complete genome	6137-6166	0	1.0
NZ_CP026082_1	1.2\|968382\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968382-968411	30	MK448953	Streptococcus phage Javan474, complete genome	9267-9296	0	1.0
NZ_CP026082_1	1.2\|968382\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968382-968411	30	MK448945	Streptococcus phage Javan454, complete genome	9851-9880	0	1.0
NZ_CP026082_1	1.2\|968382\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968382-968411	30	MK448941	Streptococcus phage Javan446, complete genome	10614-10643	0	1.0
NZ_CP026082_1	1.2\|968382\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968382-968411	30	MH853358	Streptococcus phage LF4, complete genome	35307-35336	0	1.0
NZ_CP026082_1	1.2\|968382\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968382-968411	30	MK448957	Streptococcus phage Javan484, complete genome	10247-10276	0	1.0
NZ_CP026082_1	1.1\|968316\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968316-968345	30	JX409895	Streptococcus phage JX01, complete genome	17552-17581	1	0.967
NZ_CP026082_1	1.7\|968712\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968712-968741	30	NC_022077	Streptococcus pyogenes strain A852 plasmid pA852, complete sequence	97-126	1	0.967
NZ_CP026082_1	1.3\|968448\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968448-968477	30	MK448829	Streptococcus phage Javan7, complete genome	14006-14035	2	0.933
NZ_CP026082_1	1.3\|968448\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968448-968477	30	MH853355	Streptococcus phage LF1, complete genome	4863-4892	2	0.933
NZ_CP026082_1	1.3\|968448\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968448-968477	30	MH853358	Streptococcus phage LF4, complete genome	4863-4892	2	0.933
NZ_CP026082_1	1.7\|968712\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968712-968741	30	NZ_MG944248	Lactobacillus plantarum strain LP27 plasmid pLP27, complete sequence	638-667	5	0.833
NZ_CP026082_1	1.1\|968316\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968316-968345	30	AP014263	Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S35-C248, * SEQUENCING IN PROGRESS *	3926-3955	6	0.8
NZ_CP026082_1	1.1\|968316\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968316-968345	30	MN693114	Marine virus AFVG_25M536, complete genome	14090-14119	6	0.8
NZ_CP026082_1	1.6\|968646\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968646-968675	30	CP041517	Bacillus aryabhattai strain KNU10 plasmid unnamed1, complete sequence	142885-142914	6	0.8
NZ_CP026082_1	1.6\|968646\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968646-968675	30	MN694760	Marine virus AFVG_250M661, complete genome	1771-1800	6	0.8
NZ_CP026082_1	1.8\|968778\|30\|NZ_CP026082\|CRISPRCasFinder,CRT	968778-968807	30	NC_047897	Lactobacillus phage Lenus, complete genome	65427-65456	6	0.8
NZ_CP026082_1	1.8\|968778\|30\|NZ_CP026082\|CRISPRCasFinder,CRT	968778-968807	30	AP013698	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C55A-MedDCM-OCT-S36-C68, * SEQUENCING IN PROGRESS *	17874-17903	6	0.8
NZ_CP026082_3	3.5\|2154602\|30\|NZ_CP026082\|CRT	2154602-2154631	30	MG649966	Vibrio virus Ceto, complete genome	7002-7031	6	0.8
NZ_CP026082_3	3.5\|2154602\|30\|NZ_CP026082\|CRT	2154602-2154631	30	MG649966	Vibrio virus Ceto, complete genome	126942-126971	6	0.8
NZ_CP026082_3	3.5\|2154602\|30\|NZ_CP026082\|CRT	2154602-2154631	30	NC_042094	Vibrio phage Ceto, complete genome	7002-7031	6	0.8
NZ_CP026082_3	3.5\|2154602\|30\|NZ_CP026082\|CRT	2154602-2154631	30	NC_042094	Vibrio phage Ceto, complete genome	126942-126971	6	0.8
NZ_CP026082_3	3.8\|2154734\|30\|NZ_CP026082\|CRT	2154734-2154763	30	NC_011775	Bacillus cereus G9842 plasmid pG9842_209, complete sequence	30936-30965	6	0.8
NZ_CP026082_3	3.8\|2154734\|30\|NZ_CP026082\|CRT	2154734-2154763	30	NZ_CP004872	Bacillus thuringiensis serovar kurstaki str. HD-1 plasmid pBMB64, complete sequence	16931-16960	6	0.8
NZ_CP026082_1	1.1\|968316\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968316-968345	30	MK415406	Phage FAKO27_000238F, complete genome	53101-53130	7	0.767
NZ_CP026082_1	1.3\|968448\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968448-968477	30	NC_011973	Bacillus cereus Q1 plasmid pBc239, complete sequence	94092-94121	7	0.767
NZ_CP026082_1	1.3\|968448\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968448-968477	30	NC_018492	Bacillus cereus FRI-35 plasmid p01, complete sequence	198714-198743	7	0.767
NZ_CP026082_1	1.6\|968646\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968646-968675	30	NZ_CP015333	Borrelia hermsii HS1 isolate Browne Mountain plasmid lpV47, complete sequence	1648-1677	7	0.767
NZ_CP026082_1	1.6\|968646\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968646-968675	30	NZ_LR215006	Mycoplasma conjunctivae strain NCTC10147 plasmid 10	6294-6323	7	0.767
NZ_CP026082_1	1.6\|968646\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968646-968675	30	NC_019349	Lactococcus lactis subsp. cremoris plasmid pAF12, complete sequence	7649-7678	7	0.767
NZ_CP026082_1	1.6\|968646\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968646-968675	30	NZ_MH785233	Staphylococcus aureus strain ph2 plasmid pPH2, complete sequence	15282-15311	7	0.767
NZ_CP026082_1	1.8\|968778\|30\|NZ_CP026082\|CRISPRCasFinder,CRT	968778-968807	30	NC_047925	Lactobacillus phage Nyseid, complete genome	67879-67908	7	0.767
NZ_CP026082_1	1.8\|968778\|30\|NZ_CP026082\|CRISPRCasFinder,CRT	968778-968807	30	KU052488	Lactobacillus phage SA-C12, complete genome	24549-24578	7	0.767
NZ_CP026082_1	1.8\|968778\|30\|NZ_CP026082\|CRISPRCasFinder,CRT	968778-968807	30	MN693473	Marine virus AFVG_25M504, complete genome	22237-22266	7	0.767
NZ_CP026082_3	3.5\|2154602\|30\|NZ_CP026082\|CRT	2154602-2154631	30	NC_028835	Lactobacillus phage CL2, complete genome	3498-3527	7	0.767
NZ_CP026082_3	3.5\|2154602\|30\|NZ_CP026082\|CRT	2154602-2154631	30	KR905066	Lactobacillus phage CL1, complete genome	2483-2512	7	0.767
NZ_CP026082_3	3.5\|2154602\|30\|NZ_CP026082\|CRT	2154602-2154631	30	MN855763	Myoviridae sp. isolate 210, complete genome	165192-165221	7	0.767
NZ_CP026082_3	3.5\|2154602\|30\|NZ_CP026082\|CRT	2154602-2154631	30	NC_028911	Lactobacillus phage iLp1308, complete genome	2579-2608	7	0.767
NZ_CP026082_3	3.5\|2154602\|30\|NZ_CP026082\|CRT	2154602-2154631	30	NZ_LR699556	Paraburkholderia sp. Msb3 isolate PDMSB31 plasmid pII	50784-50813	7	0.767
NZ_CP026082_3	3.5\|2154602\|30\|NZ_CP026082\|CRT	2154602-2154631	30	NZ_CP026426	Acinetobacter sp. ACNIH1 plasmid pACI-df08, complete sequence	224625-224654	7	0.767
NZ_CP026082_3	3.8\|2154734\|30\|NZ_CP026082\|CRT	2154734-2154763	30	MG575419	Proteus phage vB_PmiP_RS8pmA, complete genome	23998-24027	7	0.767
NZ_CP026082_1	1.1\|968316\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968316-968345	30	NC_010418	Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete sequence	83667-83696	8	0.733
NZ_CP026082_1	1.1\|968316\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968316-968345	30	NC_010418	Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete sequence	162006-162035	8	0.733
NZ_CP026082_1	1.1\|968316\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968316-968345	30	NZ_CP021149	Vibrio campbellii strain LA16-V1 plasmid pLA16-3, complete sequence	18563-18592	8	0.733
NZ_CP026082_1	1.1\|968316\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968316-968345	30	NZ_CP013682	Clostridium botulinum strain 1169 plasmid pRSJ8_1, complete sequence	190692-190721	8	0.733
NZ_CP026082_1	1.1\|968316\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968316-968345	30	NZ_CP013295	Clostridium botulinum strain CDC_54064 plasmid pNPD1_1, complete sequence	4427-4456	8	0.733
NZ_CP026082_1	1.1\|968316\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968316-968345	30	NC_021517	Lactobacillus plantarum 16 plasmid Lp16E, complete sequence	17393-17422	8	0.733
NZ_CP026082_1	1.1\|968316\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968316-968345	30	KF831354	Staphylococcus phage phiBU01, complete genome	41142-41171	8	0.733
NZ_CP026082_1	1.1\|968316\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968316-968345	30	KX232515	Staphylococcus phage 3 AJ-2017, complete genome	41330-41359	8	0.733
NZ_CP026082_1	1.1\|968316\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968316-968345	30	NC_029073	Geobacillus virus E3, complete genome	124959-124988	8	0.733
NZ_CP026082_1	1.6\|968646\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968646-968675	30	NZ_CP008811	Campylobacter fetus subsp. venerealis 97/608 plasmid pCFV97608-1, complete sequence	26335-26364	8	0.733
NZ_CP026082_1	1.6\|968646\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968646-968675	30	NZ_CP020744	Bacillus mycoides strain Gnyt1 plasmid unnamed1, complete sequence	382960-382989	8	0.733
NZ_CP026082_1	1.6\|968646\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968646-968675	30	MH321490	Staphylococcus phage Quidividi, complete genome	26262-26291	8	0.733
NZ_CP026082_1	1.6\|968646\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968646-968675	30	MH321491	Staphylococcus phage Twillingate, complete genome	27531-27560	8	0.733
NZ_CP026082_1	1.8\|968778\|30\|NZ_CP026082\|CRISPRCasFinder,CRT	968778-968807	30	AP018932	Escherichia phage KIT03 DNA, complete sequence	154828-154857	8	0.733
NZ_CP026082_3	3.4\|2154554\|30\|NZ_CP026082\|CRT	2154554-2154583	30	MN855875	Bacteriophage sp. isolate 328, complete genome	1402-1431	8	0.733
NZ_CP026082_3	3.5\|2154602\|30\|NZ_CP026082\|CRT	2154602-2154631	30	NC_019526	Enterobacteria phage vB_KleM-RaK2, complete genome	222237-222266	8	0.733
NZ_CP026082_3	3.5\|2154602\|30\|NZ_CP026082\|CRT	2154602-2154631	30	AB897757	Klebsiella phage K64-1 DNA, complete genome	221614-221643	8	0.733
NZ_CP026082_3	3.5\|2154602\|30\|NZ_CP026082\|CRT	2154602-2154631	30	KP881232	Sinorhizobium phage phiM9, complete genome	66907-66936	8	0.733
NZ_CP026082_3	3.5\|2154602\|30\|NZ_CP026082\|CRT	2154602-2154631	30	MN698241	Pelagibacter phage HTVC027P, complete genome	16583-16612	8	0.733
NZ_CP026082_3	3.6\|2154650\|30\|NZ_CP026082\|CRT	2154650-2154679	30	MN855875	Bacteriophage sp. isolate 328, complete genome	1402-1431	8	0.733
NZ_CP026082_1	1.1\|968316\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968316-968345	30	NC_022111	Prevotella sp. oral taxon 299 str. F0039 plasmid, complete sequence	1347964-1347993	9	0.7
NZ_CP026082_1	1.6\|968646\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968646-968675	30	MN163280	Klebsiella phage KpGranit, complete genome	34333-34362	9	0.7
NZ_CP026082_1	1.6\|968646\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968646-968675	30	MK630230	Klebsiella phage Spivey, complete genome	85771-85800	9	0.7
NZ_CP026082_1	1.6\|968646\|30\|NZ_CP026082\|PILER-CR,CRISPRCasFinder,CRT	968646-968675	30	MG459987	Klebsiella phage Sugarland, complete genome	34772-34801	9	0.7

1. spacer 1.2|968382|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to MK448755 (Streptococcus phage Javan423, complete genome) position: , mismatch: 0, identity: 1.0

tcagaaaaagaaatatatagcgcctacaat	CRISPR spacer
tcagaaaaagaaatatatagcgcctacaat	Protospacer
******************************

2. spacer 1.2|968382|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to MK448829 (Streptococcus phage Javan7, complete genome) position: , mismatch: 0, identity: 1.0

tcagaaaaagaaatatatagcgcctacaat	CRISPR spacer
tcagaaaaagaaatatatagcgcctacaat	Protospacer
******************************

3. spacer 1.2|968382|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to MH853355 (Streptococcus phage LF1, complete genome) position: , mismatch: 0, identity: 1.0

tcagaaaaagaaatatatagcgcctacaat	CRISPR spacer
tcagaaaaagaaatatatagcgcctacaat	Protospacer
******************************

4. spacer 1.2|968382|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to MK448970 (Streptococcus phage Javan516, complete genome) position: , mismatch: 0, identity: 1.0

tcagaaaaagaaatatatagcgcctacaat	CRISPR spacer
tcagaaaaagaaatatatagcgcctacaat	Protospacer
******************************

5. spacer 1.2|968382|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to MK448756 (Streptococcus phage Javan425, complete genome) position: , mismatch: 0, identity: 1.0

tcagaaaaagaaatatatagcgcctacaat	CRISPR spacer
tcagaaaaagaaatatatagcgcctacaat	Protospacer
******************************

6. spacer 1.2|968382|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to MK448953 (Streptococcus phage Javan474, complete genome) position: , mismatch: 0, identity: 1.0

tcagaaaaagaaatatatagcgcctacaat	CRISPR spacer
tcagaaaaagaaatatatagcgcctacaat	Protospacer
******************************

7. spacer 1.2|968382|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to MK448945 (Streptococcus phage Javan454, complete genome) position: , mismatch: 0, identity: 1.0

tcagaaaaagaaatatatagcgcctacaat	CRISPR spacer
tcagaaaaagaaatatatagcgcctacaat	Protospacer
******************************

8. spacer 1.2|968382|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to MK448941 (Streptococcus phage Javan446, complete genome) position: , mismatch: 0, identity: 1.0

tcagaaaaagaaatatatagcgcctacaat	CRISPR spacer
tcagaaaaagaaatatatagcgcctacaat	Protospacer
******************************

9. spacer 1.2|968382|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to MH853358 (Streptococcus phage LF4, complete genome) position: , mismatch: 0, identity: 1.0

tcagaaaaagaaatatatagcgcctacaat	CRISPR spacer
tcagaaaaagaaatatatagcgcctacaat	Protospacer
******************************

10. spacer 1.2|968382|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to MK448957 (Streptococcus phage Javan484, complete genome) position: , mismatch: 0, identity: 1.0

tcagaaaaagaaatatatagcgcctacaat	CRISPR spacer
tcagaaaaagaaatatatagcgcctacaat	Protospacer
******************************

11. spacer 1.1|968316|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to JX409895 (Streptococcus phage JX01, complete genome) position: , mismatch: 1, identity: 0.967

catttttttgtaatacttatctttatttga	CRISPR spacer
cattgttttgtaatacttatctttatttga	Protospacer
**** *************************

12. spacer 1.7|968712|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to NC_022077 (Streptococcus pyogenes strain A852 plasmid pA852, complete sequence) position: , mismatch: 1, identity: 0.967

gtctttatcatgaagcggactaaccgctat	CRISPR spacer
gtctctatcatgaagcggactaaccgctat	Protospacer
****.*************************

13. spacer 1.3|968448|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to MK448829 (Streptococcus phage Javan7, complete genome) position: , mismatch: 2, identity: 0.933

tcgcaataattactatatgattaagcgcaa	CRISPR spacer
tcgcaataattactatatgcttaagcggaa	Protospacer
******************* ******* **

14. spacer 1.3|968448|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to MH853355 (Streptococcus phage LF1, complete genome) position: , mismatch: 2, identity: 0.933

tcgcaataattactatatgattaagcgcaa	CRISPR spacer
tcgcaataattactatatgcttaagcggaa	Protospacer
******************* ******* **

15. spacer 1.3|968448|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to MH853358 (Streptococcus phage LF4, complete genome) position: , mismatch: 2, identity: 0.933

tcgcaataattactatatgattaagcgcaa	CRISPR spacer
tcgcaataattactatatgcttaagcggaa	Protospacer
******************* ******* **

16. spacer 1.7|968712|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to NZ_MG944248 (Lactobacillus plantarum strain LP27 plasmid pLP27, complete sequence) position: , mismatch: 5, identity: 0.833

gtctttatcatgaagcggactaaccgctat	CRISPR spacer
atccctatcatgaagcggactaatcgcaat	Protospacer
.**..******************.*** **

17. spacer 1.1|968316|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to AP014263 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S35-C248, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 6, identity: 0.8

catttttttgtaatacttatctttatttga	CRISPR spacer
catttttttgtcataattatcttccattaa	Protospacer
*********** *** *******.  **.*

18. spacer 1.1|968316|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to MN693114 (Marine virus AFVG_25M536, complete genome) position: , mismatch: 6, identity: 0.8

catttttttgtaatacttatctttatttga	CRISPR spacer
catttttttgtcataattatcttccattaa	Protospacer
*********** *** *******.  **.*

19. spacer 1.6|968646|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to CP041517 (Bacillus aryabhattai strain KNU10 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.8

agagttacaataagttagaaaataaaatta	CRISPR spacer
agagttataatatgttagaaaataagtatt	Protospacer
*******.**** ************.  *

20. spacer 1.6|968646|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to MN694760 (Marine virus AFVG_250M661, complete genome) position: , mismatch: 6, identity: 0.8

agagttacaataagttagaaaataaaatta	CRISPR spacer
agcttctaaataagttagaaaataaaaata	Protospacer
**  *.  ******************* **

21. spacer 1.8|968778|30|NZ_CP026082|CRISPRCasFinder,CRT matches to NC_047897 (Lactobacillus phage Lenus, complete genome) position: , mismatch: 6, identity: 0.8

tggttatacatttactaatccatcagcatt	CRISPR spacer
ggatggtactgttactaatccatcagcatt	Protospacer
 *.* .***  *******************

22. spacer 1.8|968778|30|NZ_CP026082|CRISPRCasFinder,CRT matches to AP013698 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C55A-MedDCM-OCT-S36-C68, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 6, identity: 0.8

-tggttatacatttactaatccatcagcatt	CRISPR spacer
ctcagta-acagttactaatacatcagcatt	Protospacer
 * . ** *** ******** **********

23. spacer 3.5|2154602|30|NZ_CP026082|CRT matches to MG649966 (Vibrio virus Ceto, complete genome) position: , mismatch: 6, identity: 0.8

tttggcttctggtttagcttctggcttagc	CRISPR spacer
tttggcttcttgtttagcttctgctttttg	Protospacer
********** ************ .**

24. spacer 3.5|2154602|30|NZ_CP026082|CRT matches to MG649966 (Vibrio virus Ceto, complete genome) position: , mismatch: 6, identity: 0.8

tttggcttctggtttagcttctggcttagc	CRISPR spacer
tttggcttcttgtttagcttctgctttttg	Protospacer
********** ************ .**

25. spacer 3.5|2154602|30|NZ_CP026082|CRT matches to NC_042094 (Vibrio phage Ceto, complete genome) position: , mismatch: 6, identity: 0.8

tttggcttctggtttagcttctggcttagc	CRISPR spacer
tttggcttcttgtttagcttctgctttttg	Protospacer
********** ************ .**

26. spacer 3.5|2154602|30|NZ_CP026082|CRT matches to NC_042094 (Vibrio phage Ceto, complete genome) position: , mismatch: 6, identity: 0.8

tttggcttctggtttagcttctggcttagc	CRISPR spacer
tttggcttcttgtttagcttctgctttttg	Protospacer
********** ************ .**

27. spacer 3.8|2154734|30|NZ_CP026082|CRT matches to NC_011775 (Bacillus cereus G9842 plasmid pG9842_209, complete sequence) position: , mismatch: 6, identity: 0.8

tttggcctctggcttagcctctggtttggc	CRISPR spacer
tttaatctctggcttagtctctggtttctc	Protospacer
***...***********.*********  *

28. spacer 3.8|2154734|30|NZ_CP026082|CRT matches to NZ_CP004872 (Bacillus thuringiensis serovar kurstaki str. HD-1 plasmid pBMB64, complete sequence) position: , mismatch: 6, identity: 0.8

tttggcctctggcttagcctctggtttggc	CRISPR spacer
cttcacctctggcttagcctcaggtttttc	Protospacer
.** .**************** *****  *

29. spacer 1.1|968316|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to MK415406 (Phage FAKO27_000238F, complete genome) position: , mismatch: 7, identity: 0.767

catttttttgtaatacttatctttatttga	CRISPR spacer
cattttttttgaatacttatctttgtcaac	Protospacer
*********  *************.*. .

30. spacer 1.3|968448|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to NC_011973 (Bacillus cereus Q1 plasmid pBc239, complete sequence) position: , mismatch: 7, identity: 0.767

tcgcaataattactatatgattaagcgcaa	CRISPR spacer
taataataatcacgatatgattaagcgtag	Protospacer
* ..******.** *************.*.

31. spacer 1.3|968448|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to NC_018492 (Bacillus cereus FRI-35 plasmid p01, complete sequence) position: , mismatch: 7, identity: 0.767

tcgcaataattactatatgattaagcgcaa	CRISPR spacer
taataataatcacgatatgattaagcgtag	Protospacer
* ..******.** *************.*.

32. spacer 1.6|968646|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015333 (Borrelia hermsii HS1 isolate Browne Mountain plasmid lpV47, complete sequence) position: , mismatch: 7, identity: 0.767

agagttacaataagttagaaaataaaatta	CRISPR spacer
ttagctacaataagttcgaaaataaaaaac	Protospacer
  **.*********** **********

33. spacer 1.6|968646|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR215006 (Mycoplasma conjunctivae strain NCTC10147 plasmid 10) position: , mismatch: 7, identity: 0.767

agagttacaataagttagaaaataaaatta	CRISPR spacer
gaagcaaaaataagttataaaataaaattt	Protospacer
..**. * ********* ***********

34. spacer 1.6|968646|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to NC_019349 (Lactococcus lactis subsp. cremoris plasmid pAF12, complete sequence) position: , mismatch: 7, identity: 0.767

agagttacaataagttagaaaataaaatta	CRISPR spacer
tttgtgtcaatgagctagaaaataaaatta	Protospacer
   **  ****.**.***************

35. spacer 1.6|968646|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to NZ_MH785233 (Staphylococcus aureus strain ph2 plasmid pPH2, complete sequence) position: , mismatch: 7, identity: 0.767

agagttacaataagttagaaaataaaatta	CRISPR spacer
aagctaacaataagtttgaaaataaaagtc	Protospacer
*.. * ********** ********** *

36. spacer 1.8|968778|30|NZ_CP026082|CRISPRCasFinder,CRT matches to NC_047925 (Lactobacillus phage Nyseid, complete genome) position: , mismatch: 7, identity: 0.767

tggttatacatttactaatccatcagcatt	CRISPR spacer
ggacggtactgttactaatccatcagcatt	Protospacer
 *.. .***  *******************

37. spacer 1.8|968778|30|NZ_CP026082|CRISPRCasFinder,CRT matches to KU052488 (Lactobacillus phage SA-C12, complete genome) position: , mismatch: 7, identity: 0.767

tggttatacatttactaatccatcagcatt	CRISPR spacer
ggacggtactgttactaatccatcagcatt	Protospacer
 *.. .***  *******************

38. spacer 1.8|968778|30|NZ_CP026082|CRISPRCasFinder,CRT matches to MN693473 (Marine virus AFVG_25M504, complete genome) position: , mismatch: 7, identity: 0.767

tggttatacatttactaatccatcagcatt	CRISPR spacer
tggtgatacatttactaatcctatgccatc	Protospacer
**** ****************  .. ***.

39. spacer 3.5|2154602|30|NZ_CP026082|CRT matches to NC_028835 (Lactobacillus phage CL2, complete genome) position: , mismatch: 7, identity: 0.767

tttggcttctggtttagcttctggcttagc	CRISPR spacer
tattcattctggtttgccttctggcttagt	Protospacer
* *   *********. ************.

40. spacer 3.5|2154602|30|NZ_CP026082|CRT matches to KR905066 (Lactobacillus phage CL1, complete genome) position: , mismatch: 7, identity: 0.767

tttggcttctggtttagcttctggcttagc	CRISPR spacer
tattcattctggtttgccttctggcttagt	Protospacer
* *   *********. ************.

41. spacer 3.5|2154602|30|NZ_CP026082|CRT matches to MN855763 (Myoviridae sp. isolate 210, complete genome) position: , mismatch: 7, identity: 0.767

tttggcttctggtttagcttctggcttagc	CRISPR spacer
cttatcttctggtttatcttctggctcgtc	Protospacer
.**. *********** *********.. *

42. spacer 3.5|2154602|30|NZ_CP026082|CRT matches to NC_028911 (Lactobacillus phage iLp1308, complete genome) position: , mismatch: 7, identity: 0.767

tttggcttctggtttagcttctggcttagc	CRISPR spacer
tattcattctggtttgccttctggcttagt	Protospacer
* *   *********. ************.

43. spacer 3.5|2154602|30|NZ_CP026082|CRT matches to NZ_LR699556 (Paraburkholderia sp. Msb3 isolate PDMSB31 plasmid pII) position: , mismatch: 7, identity: 0.767

tttggcttctggtttagcttctggcttagc	CRISPR spacer
tggagcttctggcttagcttatggcttgtc	Protospacer
*  .********.******* ******. *

44. spacer 3.5|2154602|30|NZ_CP026082|CRT matches to NZ_CP026426 (Acinetobacter sp. ACNIH1 plasmid pACI-df08, complete sequence) position: , mismatch: 7, identity: 0.767

tttggcttctggtttagcttctggcttagc	CRISPR spacer
atttacagatggtttagcttctagcttagc	Protospacer
 ** .*   *************.*******

45. spacer 3.8|2154734|30|NZ_CP026082|CRT matches to MG575419 (Proteus phage vB_PmiP_RS8pmA, complete genome) position: , mismatch: 7, identity: 0.767

tttggcctctggcttagcctctggtttggc	CRISPR spacer
ttcagcctctgtcttagcatctggtttaat	Protospacer
**..******* ****** ********...

46. spacer 1.1|968316|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to NC_010418 (Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete sequence) position: , mismatch: 8, identity: 0.733

catttttttgtaatacttatctttatttga	CRISPR spacer
aatttctttgtaattcttatctttaaaacc	Protospacer
 ****.******** **********

47. spacer 1.1|968316|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to NC_010418 (Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete sequence) position: , mismatch: 8, identity: 0.733

catttttttgtaatacttatctttatttga	CRISPR spacer
aatttctttgtaattcttatctttaaaacc	Protospacer
 ****.******** **********

48. spacer 1.1|968316|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP021149 (Vibrio campbellii strain LA16-V1 plasmid pLA16-3, complete sequence) position: , mismatch: 8, identity: 0.733

catttttttgtaatacttatctttatttga	CRISPR spacer
atcttttttttaatatttatctttatattt	Protospacer
  .****** *****.********** *

49. spacer 1.1|968316|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013682 (Clostridium botulinum strain 1169 plasmid pRSJ8_1, complete sequence) position: , mismatch: 8, identity: 0.733

catttttttgtaatacttatctttatttga	CRISPR spacer
catatttttgtaatacttctcttgcgtaac	Protospacer
*** ************** ****   * .

50. spacer 1.1|968316|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013295 (Clostridium botulinum strain CDC_54064 plasmid pNPD1_1, complete sequence) position: , mismatch: 8, identity: 0.733

catttttttgtaatacttatctttatttga	CRISPR spacer
catatttttgtaatacttctcttgcgtaac	Protospacer
*** ************** ****   * .

51. spacer 1.1|968316|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to NC_021517 (Lactobacillus plantarum 16 plasmid Lp16E, complete sequence) position: , mismatch: 8, identity: 0.733

catttttttgtaatacttatctttatttga	CRISPR spacer
tcgttttttgaaattcttatctttatcata	Protospacer
.  ******* *** ***********.  *

52. spacer 1.1|968316|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to KF831354 (Staphylococcus phage phiBU01, complete genome) position: , mismatch: 8, identity: 0.733

catttttttgtaatacttatctttatttga	CRISPR spacer
gtatattttgtaatagttatctgtattttt	Protospacer
   * ********** ****** *****

53. spacer 1.1|968316|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to KX232515 (Staphylococcus phage 3 AJ-2017, complete genome) position: , mismatch: 8, identity: 0.733

catttttttgtaatacttatctttatttga	CRISPR spacer
gtatattttgtaatagttatctgtattttt	Protospacer
   * ********** ****** *****

54. spacer 1.1|968316|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to NC_029073 (Geobacillus virus E3, complete genome) position: , mismatch: 8, identity: 0.733

catttttttgtaatacttatctttatttga	CRISPR spacer
atattttttataatacttttctttatattc	Protospacer
   ******.******** ******* *

55. spacer 1.6|968646|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP008811 (Campylobacter fetus subsp. venerealis 97/608 plasmid pCFV97608-1, complete sequence) position: , mismatch: 8, identity: 0.733

agagttacaataagttagaaaataaaatta	CRISPR spacer
atagttactataagttagaaaatttgctgc	Protospacer
* ****** **************  . *

56. spacer 1.6|968646|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP020744 (Bacillus mycoides strain Gnyt1 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

agagttacaataagttagaaaataaaatta	CRISPR spacer
taataaacaagaagtttgaaaataaaattc	Protospacer
 .*   **** ***** ************

57. spacer 1.6|968646|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to MH321490 (Staphylococcus phage Quidividi, complete genome) position: , mismatch: 8, identity: 0.733

agagttacaataagttagaaaataaaatta	CRISPR spacer
cgagttacaacaagttagaaaagtaatcgg	Protospacer
 *********.***********  ** . .

58. spacer 1.6|968646|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to MH321491 (Staphylococcus phage Twillingate, complete genome) position: , mismatch: 8, identity: 0.733

agagttacaataagttagaaaataaaatta	CRISPR spacer
cgagttacaacaagttagaaaagtaatcgg	Protospacer
 *********.***********  ** . .

59. spacer 1.8|968778|30|NZ_CP026082|CRISPRCasFinder,CRT matches to AP018932 (Escherichia phage KIT03 DNA, complete sequence) position: , mismatch: 8, identity: 0.733

tggttatacatttactaatccatcagcatt	CRISPR spacer
gggtaatacatttactaatccaagcgaagg	Protospacer
 *** *****************   * *

60. spacer 3.4|2154554|30|NZ_CP026082|CRT matches to MN855875 (Bacteriophage sp. isolate 328, complete genome) position: , mismatch: 8, identity: 0.733

tttggcctctggcttaacgtctggtttaac	CRISPR spacer
agtggcctctggctcaacgtctgcgccatc	Protospacer
  ************.********  ..* *

61. spacer 3.5|2154602|30|NZ_CP026082|CRT matches to NC_019526 (Enterobacteria phage vB_KleM-RaK2, complete genome) position: , mismatch: 8, identity: 0.733

tttggcttctggtttagcttctggcttagc	CRISPR spacer
aaagaattctggtttagcttctgggttatg	Protospacer
   *. ****************** ***

62. spacer 3.5|2154602|30|NZ_CP026082|CRT matches to AB897757 (Klebsiella phage K64-1 DNA, complete genome) position: , mismatch: 8, identity: 0.733

tttggcttctggtttagcttctggcttagc	CRISPR spacer
aaagaattctggtttagcttctgggttatg	Protospacer
   *. ****************** ***

63. spacer 3.5|2154602|30|NZ_CP026082|CRT matches to KP881232 (Sinorhizobium phage phiM9, complete genome) position: , mismatch: 8, identity: 0.733

tttggcttctggtttagcttctggcttagc	CRISPR spacer
ctgagcttcaggtttagcttcaggcttctt	Protospacer
.* .***** *********** *****  .

64. spacer 3.5|2154602|30|NZ_CP026082|CRT matches to MN698241 (Pelagibacter phage HTVC027P, complete genome) position: , mismatch: 8, identity: 0.733

tttggcttctggtttagcttctggcttagc	CRISPR spacer
actaggttctggtttagcttgtggcttgca	Protospacer
 .*.* ************** ******.

65. spacer 3.6|2154650|30|NZ_CP026082|CRT matches to MN855875 (Bacteriophage sp. isolate 328, complete genome) position: , mismatch: 8, identity: 0.733

tttggcctctggcttaacgtctggtttaac	CRISPR spacer
agtggcctctggctcaacgtctgcgccatc	Protospacer
  ************.********  ..* *

66. spacer 1.1|968316|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to NC_022111 (Prevotella sp. oral taxon 299 str. F0039 plasmid, complete sequence) position: , mismatch: 9, identity: 0.7

catttttttgtaatacttatctttatttga	CRISPR spacer
gcagcttttgcaatacttatttttatttct	Protospacer
    .*****.*********.*******

67. spacer 1.6|968646|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to MN163280 (Klebsiella phage KpGranit, complete genome) position: , mismatch: 9, identity: 0.7

agagttacaataagttagaaaataaaatta	CRISPR spacer
ctagttacaataagttagcaaatatctcgt	Protospacer
  **************** *****   .

68. spacer 1.6|968646|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to MK630230 (Klebsiella phage Spivey, complete genome) position: , mismatch: 9, identity: 0.7

agagttacaataagttagaaaataaaatta	CRISPR spacer
ctagttacaataagttagcaaatatctcgt	Protospacer
  **************** *****   .

69. spacer 1.6|968646|30|NZ_CP026082|PILER-CR,CRISPRCasFinder,CRT matches to MG459987 (Klebsiella phage Sugarland, complete genome) position: , mismatch: 9, identity: 0.7

agagttacaataagttagaaaataaaatta	CRISPR spacer
ctagttacaataagttagcaaatatctcgt	Protospacer
  **************** *****   .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

42013 : 50220

Synechococcus_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000220676.1\|42013_43468_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	3.7e-54	32.7
WP_001293628.1\|43495_44521_+	phosphoribosylformylglycinamidine cyclo-ligase	R9TMC7	Synechococcus_phage	8.1e-64	42.7
WP_000717515.1\|44783_45335_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	4.7e-26	35.8
WP_000780014.1\|45357_46110_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_161501761.1\|46129_47677_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	1.1e-77	49.8
WP_001045909.1\|47869_48769_+	peptidoglycan DD-metalloendopeptidase family protein	A0A221J6U0	Arthrobacter_phage	4.1e-19	45.9
WP_000783412.1\|48915_50220_+	LysM peptidoglycan-binding domain-containing protein	A0A2D1GNZ3	Streptomyces_phage	3.7e-05	40.5

DBSCAN-SWA_2

181787 : 243561

Streptococcus_phage(35.71%)

transposase,tRNA,protease,holin,integrase

attL 178667:178681|attR 247732:247746

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
178667:178681	attL	NA	NA	NA	NA
WP_000468703.1\|181787_183236_-\|transposase	IS1182-like element IS1563 family transposase	A0A1X9I5T2	Streptococcus_phage	1.3e-203	74.8
WP_001019843.1\|183405_184665_-\|tRNA	tyrosine--tRNA ligase	A0A1S6UA79	Serratia_phage	1.8e-73	41.2
WP_000472391.1\|184775_187073_+	penicillin-binding protein	NA	NA	NA	NA
WP_000907194.1\|187596_191172_+	DNA-directed RNA polymerase subunit beta	A0A2P0VMZ3	Tetraselmis_virus	9.8e-40	26.1
WP_000228723.1\|191288_194939_+	DNA-directed RNA polymerase subunit beta'	R4TQM7	Phaeocystis_globosa_virus	2.0e-64	25.1
WP_000285374.1\|195052_195418_+	DUF1033 family protein	NA	NA	NA	NA
WP_000468685.1\|195646_197107_+\|transposase	IS1182-like element IS1563 family transposase	A0A1X9I5T2	Streptococcus_phage	1.3e-203	74.8
WP_000250798.1\|197152_198124_+	Flp pilus assembly complex ATPase component TadA	NA	NA	NA	NA
WP_041981160.1\|198029_199061_+	type II secretion system F family protein	NA	NA	NA	NA
WP_000793380.1\|199057_199387_+	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_000244259.1\|199361_199775_+	type II secretion system protein	NA	NA	NA	NA
WP_001872488.1\|199746_200046_+	hypothetical protein	NA	NA	NA	NA
WP_001874060.1\|199999_200461_+	competence protein ComGF	NA	NA	NA	NA
WP_000601101.1\|200438_200810_+	hypothetical protein	NA	NA	NA	NA
WP_001008569.1\|200924_201899_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_000047534.1\|201930_203124_+	acetate kinase	NA	NA	NA	NA
WP_000468680.1\|203082_204615_-\|transposase	IS1182-like element IS1563 family transposase	A0A1X9I5T2	Streptococcus_phage	1.3e-203	74.8
WP_001872889.1\|204998_205250_+	hypothetical protein	NA	NA	NA	NA
WP_000008108.1\|205318_205984_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_001872483.1\|206004_206775_-	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	1.3e-29	34.6
WP_001281321.1\|206844_207912_-	glutamyl aminopeptidase	NA	NA	NA	NA
WP_000660180.1\|208091_208331_-	hypothetical protein	NA	NA	NA	NA
WP_000791272.1\|208491_208776_+	DUF4651 domain-containing protein	NA	NA	NA	NA
WP_000602783.1\|208772_209096_+	thioredoxin family protein	NA	NA	NA	NA
WP_000578330.1\|209128_209755_+\|tRNA	DUF4479 and tRNA-binding domain-containing protein	NA	NA	NA	NA
WP_000186179.1\|209808_210525_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_000282449.1\|210605_211001_+	single-stranded DNA-binding protein	A1EAD1	Streptococcus_phage	3.3e-29	49.2
WP_000416617.1\|211124_211769_+	HAD family hydrolase	A0A1D8KNV9	Synechococcus_phage	1.0e-11	29.2
WP_000930335.1\|211795_213541_+	sensor histidine kinase	Q9EYF3	Enterobacteria_phage	1.7e-58	29.2
WP_000697628.1\|213521_214262_+	response regulator	NA	NA	NA	NA
WP_000683315.1\|214431_214887_+	CidA/LrgA family protein	NA	NA	NA	NA
WP_000394889.1\|214888_215617_+\|holin	antiholin-like protein LrgB	NA	NA	NA	NA
WP_000170510.1\|215859_217488_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_161501770.1\|217600_218578_+	ABC transporter permease subunit	NA	NA	NA	NA
WP_000603397.1\|218574_219396_+	ABC transporter permease	NA	NA	NA	NA
WP_000140980.1\|219407_220211_+	ABC transporter ATP-binding protein	A0A2R8FG22	Brazilian_cedratvirus	4.2e-07	26.9
WP_000171306.1\|220194_220821_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.3e-16	27.0
WP_161501771.1\|221103_223134_+	PTS system trehalose-specific EIIBC component	NA	NA	NA	NA
WP_161501772.1\|223355_224954_+	alpha,alpha-phosphotrehalase	NA	NA	NA	NA
WP_000228179.1\|225196_227233_+	BglG family transcription antiterminator	NA	NA	NA	NA
WP_000944235.1\|227235_227520_+	PTS sugar transporter subunit IIB	NA	NA	NA	NA
WP_000677351.1\|227532_228888_+	PTS ascorbate transporter subunit IIC	NA	NA	NA	NA
WP_000203493.1\|228890_229748_+	transketolase	NA	NA	NA	NA
WP_001203822.1\|229744_230674_+	transketolase	NA	NA	NA	NA
WP_001203064.1\|230782_232042_+	oxidoreductase	NA	NA	NA	NA
WP_001018249.1\|232129_232399_+	30S ribosomal protein S15	NA	NA	NA	NA
WP_000043851.1\|232779_234909_+	polyribonucleotide nucleotidyltransferase	NA	NA	NA	NA
WP_000204782.1\|234910_235663_+	SseB family protein	NA	NA	NA	NA
WP_000539954.1\|235671_236256_+	serine O-acetyltransferase	NA	NA	NA	NA
WP_000656476.1\|236265_236448_+	lipoprotein	NA	NA	NA	NA
WP_000591129.1\|236444_237788_+\|tRNA	cysteine--tRNA ligase	A0A1V0SAQ2	Catovirus	1.0e-53	31.7
WP_000568031.1\|237780_238167_+	Mini-ribonuclease 3	NA	NA	NA	NA
WP_000178025.1\|238269_239025_+	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	NA	NA	NA	NA
WP_000716639.1\|239021_239540_+	hypothetical protein	NA	NA	NA	NA
WP_161501773.1\|239632_240493_+	DegV family EDD domain-containing protein	NA	NA	NA	NA
WP_000793594.1\|241030_241153_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_001867156.1\|241374_241821_+	50S ribosomal protein L13	NA	NA	NA	NA
WP_000035940.1\|241841_242234_+	30S ribosomal protein S9	NA	NA	NA	NA
WP_161501774.1\|242340_243561_-\|integrase	tyrosine-type recombinase/integrase	A0A0B5CTZ4	Listeria_phage	4.1e-06	23.5
247732:247746	attR	NA	NA	NA	NA

DBSCAN-SWA_3

424526 : 489176

Bacillus_phage(21.43%)

tRNA,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000500159.1\|424526_424970_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE	NA	NA	NA	NA
WP_167513699.1\|424962_425484_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_000708163.1\|425492_426800_+	LCP family protein	NA	NA	NA	NA
WP_161501804.1\|426816_428271_-\|transposase	IS1182-like element IS1563 family transposase	A0A1X9I5T2	Streptococcus_phage	3.7e-203	74.5
WP_000690175.1\|428424_428721_-	hypothetical protein	NA	NA	NA	NA
WP_000368097.1\|428717_429137_-	HIT family protein	NA	NA	NA	NA
WP_000773455.1\|429472_429976_+	hypothetical protein	NA	NA	NA	NA
WP_115356357.1\|430027_431506_-\|transposase	IS1182-like element IS1563 family transposase	A0A1X9I5T2	Streptococcus_phage	1.3e-203	74.8
WP_000912310.1\|431842_432568_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.1e-25	30.7
WP_069986137.1\|432569_433604_+	multidrug ABC transporter permease	NA	NA	NA	NA
WP_000155919.1\|433661_434462_+	phosphotransferase family protein	NA	NA	NA	NA
WP_001266022.1\|434451_435087_+\|tRNA	tRNA (guanosine(46)-N7)-methyltransferase TrmB	NA	NA	NA	NA
WP_044133272.1\|435574_436051_+	ribosome maturation factor RimP	NA	NA	NA	NA
WP_161501805.1\|436086_437238_+	transcription termination/antitermination protein NusA	NA	NA	NA	NA
WP_001140526.1\|437259_437556_+	YlxR family protein	NA	NA	NA	NA
WP_001065560.1\|437548_437851_+	YlxQ-related RNA-binding protein	NA	NA	NA	NA
WP_000039152.1\|437870_440654_+	translation initiation factor IF-2	A0A2H4UTS4	Bodo_saltans_virus	5.1e-20	23.1
WP_001273670.1\|440762_441113_+	30S ribosome-binding factor RbfA	NA	NA	NA	NA
WP_000804611.1\|441196_442201_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_000156042.1\|442364_442781_+	CopY/TcrY family copper transport repressor	NA	NA	NA	NA
WP_000013400.1\|442793_445028_+	copper-translocating P-type ATPase	A0A218MNH6	uncultured_virus	2.3e-95	35.0
WP_000683375.1\|445068_445275_+	heavy-metal-associated domain-containing protein	NA	NA	NA	NA
WP_000020721.1\|445384_445999_+	trimeric intracellular cation channel family protein	NA	NA	NA	NA
WP_000593332.1\|446013_446826_+	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_000182596.1\|446938_449581_+	DNA polymerase I	A0A218MKQ4	uncultured_virus	3.2e-56	28.3
WP_000262486.1\|449610_450051_+	CoA-binding protein	NA	NA	NA	NA
WP_000377092.1\|450132_450612_+	peroxide-responsive transcriptional repressor PerR	NA	NA	NA	NA
WP_000703852.1\|450765_452331_+	YSIRK signal domain/LPXTG anchor domain surface protein	NA	NA	NA	NA
WP_000192298.1\|452443_453130_+	response regulator transcription factor	W8CYM9	Bacillus_phage	1.8e-35	38.2
WP_000770244.1\|453131_454169_+	HAMP domain-containing histidine kinase	A0A1V0SGX0	Hokovirus	1.3e-13	24.6
WP_017643636.1\|454182_454923_-	DUF975 family protein	NA	NA	NA	NA
WP_000129511.1\|455109_456252_+\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.5e-85	43.1
WP_017770949.1\|456357_456669_+	hypothetical protein	NA	NA	NA	NA
WP_000469147.1\|456675_457215_+	biotin transporter BioY	NA	NA	NA	NA
WP_161501806.1\|457353_458130_+	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_001169004.1\|458129_458636_+	nucleoside deaminase	NA	NA	NA	NA
WP_000148892.1\|458906_460256_+	glucose-6-phosphate isomerase	NA	NA	NA	NA
WP_000412415.1\|460577_461105_+	5-formyltetrahydrofolate cyclo-ligase	NA	NA	NA	NA
WP_000061940.1\|461095_461773_+\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_001080265.1\|461904_462948_+	BMP family ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000868271.1\|463038_463938_-	UTP--glucose-1-phosphate uridylyltransferase GalU	A0A127AW70	Bacillus_phage	9.3e-80	53.7
WP_000166109.1\|463974_464991_-	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_000754611.1\|465160_465490_+	ribonuclease P protein component	NA	NA	NA	NA
WP_000727922.1\|465502_466318_+	membrane protein insertase YidC	NA	NA	NA	NA
WP_000242580.1\|466325_467147_+	protein jag	NA	NA	NA	NA
WP_001239184.1\|473106_473640_-	DUF402 domain-containing protein	NA	NA	NA	NA
WP_000704975.1\|473723_474500_-	recombination regulator RecX	NA	NA	NA	NA
WP_001103615.1\|474598_475954_+	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	A0A2K5B251	Erysipelothrix_phage	2.3e-74	33.9
WP_161501807.1\|476345_477521_+\|transposase	IS256-like element ISSag11 family transposase	NA	NA	NA	NA
WP_000848916.1\|477750_478659_+	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_001192437.1\|479212_480223_+	class 1b ribonucleoside-diphosphate reductase subunit beta	R4TBI6	Mycobacterium_phage	1.6e-96	52.1
WP_000378630.1\|480223_480637_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	NA	NA	NA	NA
WP_000194378.1\|480638_482807_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A0D3MSW9	Lactococcus_phage	1.2e-170	46.1
WP_161501808.1\|482869_486037_+	leucine-rich repeat protein	NA	NA	NA	NA
WP_000191687.1\|486268_487444_-\|transposase	IS256-like element ISSag11 family transposase	NA	NA	NA	NA
WP_044133052.1\|487435_487759_+	hypothetical protein	NA	NA	NA	NA
WP_167513700.1\|487831_489176_+\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	3.1e-63	49.6

DBSCAN-SWA_4

612638 : 624036

Streptococcus_phage(66.67%)

integrase

attL 610787:610804|attR 617698:617715

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
610787:610804	attL	NA	NA	NA	NA
WP_000595708.1\|612638_613835_+	voltage-gated chloride channel family protein	A0A1X9I5Z9	Streptococcus_phage	4.6e-103	54.5
WP_001068667.1\|614417_614765_+	50S ribosomal protein L19	NA	NA	NA	NA
WP_000264730.1\|614989_616069_-\|integrase	site-specific integrase	A0A1X9IGD8	Lactococcus_phage	3.2e-63	39.8
WP_000505363.1\|616192_616396_-	hypothetical protein	O34033	Streptococcus_phage	1.7e-10	48.4
WP_000891067.1\|616498_617056_-	GTP pyrophosphokinase	Q0H269	Geobacillus_phage	1.6e-18	30.2
WP_000998374.1\|617057_617789_-	helix-turn-helix domain-containing protein	J7KJ52	Streptococcus_phage	3.0e-89	67.2
617698:617715	attR	NA	NA	NA	NA
WP_001104149.1\|618156_618315_+	hypothetical protein	J7KH24	Streptococcus_phage	2.2e-21	92.3
WP_001872966.1\|618349_618526_+	hypothetical protein	NA	NA	NA	NA
WP_000076709.1\|619364_619544_+	CsbD family protein	J7KJ36	Streptococcus_phage	4.3e-21	96.4
WP_000027835.1\|619585_619774_+	hypothetical protein	J7KIW4	Streptococcus_phage	3.3e-16	78.2
WP_000078931.1\|620198_621404_+	rod shape-determining protein RodA	NA	NA	NA	NA
WP_001106189.1\|621522_622083_+	HAD-IA family hydrolase	NA	NA	NA	NA
WP_000134199.1\|622083_624036_+	DNA topoisomerase (ATP-hydrolyzing) subunit B	G3M9Z3	Bacillus_virus	7.5e-143	44.7

DBSCAN-SWA_5

700712 : 806171

Streptococcus_phage(72.22%)

tRNA,transposase,capsid,head,protease,portal,tail,terminase,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000591020.1\|700712_702656_+\|tRNA	threonine--tRNA ligase	A0A2K9L297	Tupanvirus	2.0e-119	37.9
WP_001261248.1\|702877_703582_+	response regulator transcription factor	W8CYM9	Bacillus_phage	5.6e-32	34.1
WP_001140265.1\|703678_704698_+	DUF3114 domain-containing protein	NA	NA	NA	NA
WP_000592390.1\|704864_705431_+	peptidase	NA	NA	NA	NA
WP_000100034.1\|707335_707986_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_000173639.1\|707997_708693_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_000946171.1\|708705_709506_-	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_161501822.1\|709517_710273_-	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	4.3e-38	41.7
WP_000722052.1\|710612_711323_+	response regulator transcription factor	W8CYM9	Bacillus_phage	3.1e-38	38.5
WP_001065469.1\|711315_712665_+	cell wall metabolism sensor histidine kinase VicK	W8CYF6	Bacillus_phage	2.7e-35	33.8
WP_001289498.1\|712668_713478_+	MBL fold metallo-hydrolase	A0A0C5AJ83	Bacteriophage	2.5e-39	37.6
WP_000719385.1\|713480_713849_+	YbaN family protein	NA	NA	NA	NA
WP_000661525.1\|714024_714711_+	ribonuclease III	A0A167RGU4	Powai_lake_megavirus	1.3e-20	29.9
WP_047212078.1\|714718_718258_+	chromosome segregation protein SMC	NA	NA	NA	NA
WP_161501823.1\|719262_720513_-	YSIRK-targeted surface antigen transcriptional regulator	NA	NA	NA	NA
WP_161501975.1\|728199_729471_-\|transposase	IS66 family transposase	NA	NA	NA	NA
WP_000391861.1\|729442_729628_-\|transposase	transposase	NA	NA	NA	NA
WP_000154547.1\|729681_730032_-	IS66 family insertion sequence element accessory protein TnpB	NA	NA	NA	NA
WP_047209502.1\|730021_730204_-	hypothetical protein	NA	NA	NA	NA
WP_000673009.1\|730291_730501_-	helix-turn-helix domain-containing protein	A0A2K5B263	Erysipelothrix_phage	4.8e-16	58.5
WP_161501824.1\|730490_732149_-	DUF2326 domain-containing protein	NA	NA	NA	NA
WP_001176803.1\|732139_732364_-	hypothetical protein	NA	NA	NA	NA
WP_047212073.1\|732363_733482_-	hypothetical protein	NA	NA	NA	NA
WP_000182251.1\|733915_734512_+	hypothetical protein	A0A1B0RXB3	Streptococcus_phage	2.5e-12	30.5
WP_047209453.1\|735274_737224_-	DNA polymerase	D0R0B0	Streptococcus_phage	0.0e+00	84.0
WP_047212072.1\|737296_737860_-	DUF2815 family protein	E4ZFK3	Streptococcus_phage	2.1e-90	91.2
WP_161501825.1\|737864_738986_-	DUF2800 domain-containing protein	M1Q218	Streptococcus_phage	5.0e-200	89.3
WP_047209381.1\|738978_739302_-	hypothetical protein	D0R0B4	Streptococcus_phage	3.4e-32	72.0
WP_047209382.1\|739660_741949_+	phage/plasmid primase P4 family domain-containing protein	A0A1B0RXC5	Streptococcus_phage	0.0e+00	87.3
WP_047209383.1\|742228_742510_+	VRR-NUC domain-containing protein	M1PFY8	Streptococcus_phage	1.8e-37	78.5
WP_047209384.1\|742490_743867_+	DEAD/DEAH box helicase	A0A1X9I6B0	Streptococcus_phage	1.6e-232	86.7
WP_000356296.1\|743859_744336_+	hypothetical protein	A0A1B0RXB9	Streptococcus_phage	4.1e-71	84.2
WP_000166941.1\|744530_744713_+	hypothetical protein	A0A1B0RXC3	Streptococcus_phage	1.5e-21	88.3
WP_000604173.1\|744760_745798_+	methionine adenosyltransferase	E4ZFL0	Streptococcus_phage	8.0e-168	83.8
WP_001138029.1\|745799_746165_+	HNH endonuclease	Q6DMV2	Streptococcus_phage	5.1e-61	86.0
WP_001004990.1\|746452_746908_+	hypothetical protein	A0A1X9I6V0	Streptococcus_phage	2.4e-52	62.7
WP_047209385.1\|746879_748136_+	DNA modification methylase	A0A1B0RXE5	Streptococcus_phage	2.3e-225	90.4
WP_047209386.1\|748132_749386_+	DNA (cytosine-5-)-methyltransferase	M1NSK8	Streptococcus_phage	2.5e-232	94.2
WP_000164558.1\|749462_749717_+	hypothetical protein	NA	NA	NA	NA
WP_000998548.1\|749727_750177_+	DUF4314 domain-containing protein	E4ZFL7	Streptococcus_phage	7.2e-17	66.7
WP_000290863.1\|750227_750701_+\|terminase	phage terminase small subunit P27 family	A0A1X9I6K0	Streptococcus_phage	7.7e-86	98.1
WP_017647181.1\|750697_752290_+\|terminase	terminase large subunit	A0A1B0RXJ8	Streptococcus_phage	3.5e-308	95.7
WP_001140393.1\|752345_752648_+	type II toxin-antitoxin system RelB/DinJ family antitoxin	NA	NA	NA	NA
WP_000666492.1\|752647_752953_+	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_047209387.1\|753322_754612_+\|portal	phage portal protein	A0A1B0RXD8	Streptococcus_phage	1.0e-228	90.2
WP_161501826.1\|754604_755303_+\|protease	Clp protease ClpP	M1PLE5	Streptococcus_phage	3.4e-106	84.1
WP_000040503.1\|755316_756525_+\|capsid	phage major capsid protein	M1Q1R5	Streptococcus_phage	1.4e-211	91.5
WP_000988606.1\|756521_756779_+\|head,tail	phage gp6-like head-tail connector protein	D0R0D7	Streptococcus_phage	7.3e-30	78.8
WP_000684960.1\|756778_757117_+\|head,tail	head-tail adaptor protein	A0A1B0RXJ6	Streptococcus_phage	4.3e-38	70.5
WP_047209389.1\|757109_757478_+	HK97 gp10 family phage protein	Q6DMT7	Streptococcus_phage	4.5e-33	61.2
WP_001209976.1\|757486_757813_+	hypothetical protein	M1Q1Z4	Streptococcus_phage	4.1e-38	68.5
WP_000818568.1\|757815_758385_+\|tail	phage tail protein	A0A1B0RXE2	Streptococcus_phage	3.3e-99	95.7
WP_001249612.1\|758396_758816_+	hypothetical protein	A0A1X9I691	Streptococcus_phage	1.3e-57	78.4
WP_047209390.1\|758998_762052_+	TMP repeat protein	Q6DMT2	Streptococcus_phage	7.4e-254	76.1
WP_047209391.1\|762048_762774_+\|tail	phage tail protein	Q6DMT1	Streptococcus_phage	3.6e-82	57.9
WP_047209402.1\|762773_765689_+	carbamoylsarcosine amidase	Q6DMT0	Streptococcus_phage	0.0e+00	64.6
WP_161501827.1\|765701_767558_+	hypothetical protein	Q6DMS9	Streptococcus_phage	3.3e-257	72.9
WP_047209393.1\|767575_767980_+\|holin	phage holin family protein	D0R0E9	Streptococcus_phage	1.1e-45	74.0
WP_161501828.1\|767981_769451_+	LysM peptidoglycan-binding domain-containing protein	A0A1X9I678	Streptococcus_phage	7.0e-226	78.9
WP_047209395.1\|769560_769962_+	RNA polymerase subunit sigma-70	NA	NA	NA	NA
WP_047209396.1\|769958_770120_+	hypothetical protein	Q6DMS7	Streptococcus_phage	8.3e-08	58.8
WP_047209397.1\|770176_771385_+	recombinase family protein	Q6DMS6	Streptococcus_phage	1.8e-102	50.5
WP_047209398.1\|771387_772953_+	recombinase family protein	Q6DMS5	Streptococcus_phage	2.4e-176	60.5
WP_001280061.1\|773708_774533_+	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_000522263.1\|774532_776143_+	signal recognition particle-docking protein FtsY	NA	NA	NA	NA
WP_069986291.1\|776693_777971_+	group II intron reverse transcriptase/maturase	NA	NA	NA	NA
WP_000617815.1\|778036_778849_-	TIGR03943 family protein	NA	NA	NA	NA
WP_000350889.1\|778848_779751_-	permease	NA	NA	NA	NA
WP_001018624.1\|779756_779885_-	hypothetical protein	NA	NA	NA	NA
WP_000571060.1\|780017_781061_+	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_000429379.1\|781166_783329_+	RNA-binding transcriptional accessory protein	NA	NA	NA	NA
WP_165727782.1\|783273_783762_+	SprT family protein	U5J9G1	Bacillus_phage	1.8e-05	26.3
WP_000842478.1\|783830_784094_+	PspC domain-containing protein	NA	NA	NA	NA
WP_000301753.1\|784321_785257_+	HPr kinase/phosphorylase	NA	NA	NA	NA
WP_000609728.1\|785249_786023_+	prolipoprotein diacylglyceryl transferase	NA	NA	NA	NA
WP_000569599.1\|786037_786436_+	DUF948 domain-containing protein	NA	NA	NA	NA
WP_017650287.1\|786432_786864_+	YtxH domain-containing protein	NA	NA	NA	NA
WP_000468692.1\|786823_788332_-\|transposase	IS1182-like element IS1563 family transposase	A0A1X9I5T2	Streptococcus_phage	1.3e-203	74.8
WP_000097985.1\|788467_788743_-	DUF3270 domain-containing protein	NA	NA	NA	NA
WP_000411251.1\|789084_790011_+	U32 family peptidase	NA	NA	NA	NA
WP_000073158.1\|790140_791427_+	U32 family peptidase	Q6DW11	Phage_TP	1.9e-41	32.4
WP_001288869.1\|791553_791766_+	hypothetical protein	NA	NA	NA	NA
WP_017650271.1\|791889_792687_+	hypothetical protein	NA	NA	NA	NA
WP_001073014.1\|792787_794128_-	divalent metal cation transporter	NA	NA	NA	NA
WP_161501829.1\|794713_796177_-\|transposase	IS1182-like element IS1563 family transposase	A0A1X9I5T2	Streptococcus_phage	1.3e-203	74.8
WP_017650270.1\|796423_797533_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A1V0SE20	Indivirus	2.6e-55	36.9
WP_000493859.1\|797513_798164_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	4.5e-36	41.5
WP_161501830.1\|798181_799375_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	5.1e-110	50.5
WP_000152414.1\|799389_799860_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	1.3e-40	52.7
WP_017650268.1\|799934_801425_-\|tRNA	lysine--tRNA ligase	A0A1V0SAC0	Catovirus	1.5e-90	39.4
WP_017650267.1\|801599_802502_+	HAD family hydrolase	NA	NA	NA	NA
WP_000675284.1\|802537_803179_-	histidine phosphatase family protein	NA	NA	NA	NA
WP_000038840.1\|803200_803674_-\|tRNA	aminoacyl-tRNA deacylase	NA	NA	NA	NA
WP_000404301.1\|803968_804586_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_115343210.1\|804716_806171_+\|transposase	IS1182-like element IS1563 family transposase	A0A1X9I5T2	Streptococcus_phage	1.3e-203	74.8

DBSCAN-SWA_6

978384 : 1032553

Streptococcus_phage(81.03%)

capsid,portal,tail,terminase,integrase,holin

attL 983239:983256|attR 1026354:1026371

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000168905.1\|978384_981177_+	cation-transporting P-type ATPase	M1HK51	Paramecium_bursaria_Chlorella_virus	7.8e-77	29.8
WP_000065321.1\|981176_982280_+	DUF2974 domain-containing protein	NA	NA	NA	NA
WP_000146565.1\|982330_982969_-	CatB-related O-acetyltransferase	A0A2R8FE91	Brazilian_cedratvirus	4.9e-19	43.4
983239:983256	attL	NA	NA	NA	NA
WP_001217739.1\|983317_984406_-\|integrase	site-specific integrase	A0A172LN96	Lactococcus_phage	9.1e-122	59.1
WP_017768461.1\|984518_984785_-	hypothetical protein	M1PF81	Streptococcus_phage	3.6e-08	90.0
WP_124749019.1\|984894_985344_-	hypothetical protein	A0A1S5SEV0	Streptococcus_phage	1.1e-09	30.7
WP_161501842.1\|985531_986305_-	helix-turn-helix domain-containing protein	J7KJ52	Streptococcus_phage	2.4e-84	65.7
WP_000129623.1\|986669_986849_+	hypothetical protein	M1Q149	Streptococcus_phage	7.3e-05	46.8
WP_000703679.1\|986828_987026_-	hypothetical protein	M1PRU3	Streptococcus_phage	3.3e-14	63.1
WP_167513701.1\|987084_987243_+	hypothetical protein	J7KH24	Streptococcus_phage	1.9e-20	90.4
WP_154704878.1\|987276_987438_+	hypothetical protein	NA	NA	NA	NA
WP_001022150.1\|987434_987767_+	hypothetical protein	NA	NA	NA	NA
WP_000561186.1\|987763_988033_-	hypothetical protein	NA	NA	NA	NA
WP_001293718.1\|988029_988443_-	hypothetical protein	NA	NA	NA	NA
WP_001288218.1\|988510_988711_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_000759859.1\|988727_988874_+	hypothetical protein	NA	NA	NA	NA
WP_000365420.1\|988870_989353_-	hypothetical protein	A0A1P8VVS1	Streptococcus_phage	2.8e-14	33.5
WP_000658998.1\|989428_989632_+	hypothetical protein	NA	NA	NA	NA
WP_000359716.1\|989615_989975_-	hypothetical protein	NA	NA	NA	NA
WP_001166512.1\|990047_990236_+	helix-turn-helix transcriptional regulator	A0A0B5A7F0	Streptococcus_phage	1.8e-14	65.0
WP_161501843.1\|990283_991012_+	oxidoreductase	Q938N5	Temperate_phage	1.1e-118	84.7
WP_032459526.1\|991080_991305_+	hypothetical protein	A0A1S5SC19	Streptococcus_phage	2.3e-24	79.5
WP_001247544.1\|992094_992238_+	hypothetical protein	J7KIV4	Streptococcus_phage	1.6e-18	100.0
WP_000879944.1\|992387_992618_+	hypothetical protein	NA	NA	NA	NA
WP_012560974.1\|992870_993050_+	hypothetical protein	A0A1X9I5M8	Streptococcus_phage	1.2e-12	65.5
WP_000370473.1\|993222_993495_+	hypothetical protein	NA	NA	NA	NA
WP_154704826.1\|993484_993865_-	hypothetical protein	NA	NA	NA	NA
WP_161501844.1\|993920_994280_+	hypothetical protein	NA	NA	NA	NA
WP_161501845.1\|994472_995231_+	DnaD domain protein	A0A097PBE7	Streptococcus_pyogenes_phage	5.1e-71	64.4
WP_161501846.1\|995217_996000_+	ATP-binding protein	A0A097PAQ0	Streptococcus_pyogenes_phage	1.5e-131	88.8
WP_000431574.1\|996126_996402_+	hypothetical protein	J7KJY6	Streptococcus_phage	1.6e-19	61.5
WP_161501847.1\|996388_996643_+	hypothetical protein	J7KK18	Streptococcus_phage	1.3e-34	84.5
WP_017650394.1\|996645_996807_+	hypothetical protein	J7KDI4	Streptococcus_phage	1.6e-19	94.3
WP_161501848.1\|996807_997761_+	recombinase RecT	Q708Q2	Streptococcus_phage	3.5e-109	69.4
WP_161501849.1\|997757_998555_+	hypothetical protein	J7KGZ1	Streptococcus_phage	4.9e-133	86.0
WP_154700352.1\|998719_998917_+	hypothetical protein	J7KIX6	Streptococcus_phage	4.4e-27	95.4
WP_154700351.1\|998906_999383_+	RusA family crossover junction endodeoxyribonuclease	J7KBT1	Streptococcus_phage	1.6e-59	98.2
WP_017650401.1\|999372_999720_+	hypothetical protein	J7KK12	Streptococcus_phage	3.6e-56	93.0
WP_115346687.1\|999731_1000019_+	DUF1599 domain-containing protein	J7KBY0	Streptococcus_phage	2.5e-39	84.5
WP_154700370.1\|1000167_1000596_+	hypothetical protein	Q938M1	Temperate_phage	3.2e-38	64.9
WP_001002032.1\|1000592_1000811_+	hypothetical protein	A7J287	Streptococcus_phage	3.4e-12	64.5
WP_161501850.1\|1000815_1001307_+	hypothetical protein	U4KJB3	Streptococcus_phage	1.8e-29	42.7
WP_017644155.1\|1001332_1001479_+	hypothetical protein	NA	NA	NA	NA
WP_115341314.1\|1001475_1001742_+	hypothetical protein	NA	NA	NA	NA
WP_000142568.1\|1002134_1002569_+	ArpU family phage encoded transcriptional regulator	J7KDQ1	Streptococcus_phage	4.2e-70	93.7
WP_000225343.1\|1003019_1003397_+	HNH endonuclease	Q7Y4J1	Streptococcus_phage	9.3e-42	71.3
WP_000725958.1\|1003547_1003904_+	hypothetical protein	A0A0B5A7G9	Streptococcus_phage	1.3e-24	60.0
WP_001108673.1\|1003900_1005169_+\|portal	phage portal protein	M1PFL4	Streptococcus_phage	8.2e-191	76.8
WP_000421991.1\|1006381_1006570_+	hypothetical protein	NA	NA	NA	NA
WP_000256854.1\|1006677_1008093_+\|terminase	terminase	A0A0B5A091	Streptococcus_phage	1.4e-215	74.8
WP_001288696.1\|1008173_1008638_+	DUF4355 domain-containing protein	A0A0B5A7G6	Streptococcus_phage	9.7e-41	51.9
WP_000841024.1\|1008640_1009543_+\|capsid	phage major capsid protein	A0A0B5A5W3	Streptococcus_phage	1.3e-145	85.7
WP_000640308.1\|1009539_1009755_+	hypothetical protein	M1PRX2	Streptococcus_phage	3.2e-07	49.3
WP_017644150.1\|1009768_1010200_+	hypothetical protein	A0A0B5A2F6	Streptococcus_phage	8.4e-47	72.3
WP_017643415.1\|1010150_1010489_+	hypothetical protein	A0A0B5A086	Streptococcus_phage	1.6e-37	62.5
WP_000032787.1\|1010481_1010718_+	hypothetical protein	A0A1P8BMT2	Lactococcus_phage	2.5e-21	66.7
WP_000573598.1\|1010718_1011054_+	hypothetical protein	A0A1P8BMR5	Lactococcus_phage	9.8e-35	64.9
WP_161501851.1\|1011063_1011621_+\|tail	phage tail protein	M1PKG8	Streptococcus_phage	7.5e-64	65.2
WP_000448691.1\|1011620_1011866_+	hypothetical protein	A0A0B5A2F3	Streptococcus_phage	4.4e-16	57.9
WP_000909906.1\|1011880_1012255_+	DUF5361 domain-containing protein	A0A0B5A083	Streptococcus_phage	3.6e-30	54.7
WP_161501852.1\|1012254_1014267_+	PblA	Q9F4J3	Streptococcus_phage	1.9e-11	60.8
WP_161501853.1\|1014260_1015793_+\|tail	phage tail protein	J7KH53	Streptococcus_phage	5.2e-200	73.3
WP_161501854.1\|1015793_1019615_+	CHAP domain-containing protein	J7KBT9	Streptococcus_phage	0.0e+00	82.7
WP_161501855.1\|1019615_1021607_+	hypothetical protein	J7KC14	Streptococcus_phage	1.9e-298	77.9
WP_161501856.1\|1021620_1022010_+	DUF1366 domain-containing protein	J7KDI9	Streptococcus_phage	1.4e-11	43.4
WP_001017827.1\|1022169_1022472_+	hypothetical protein	J7KH30	Streptococcus_phage	3.0e-27	64.5
WP_000609110.1\|1022464_1022692_+\|holin	phage holin	A7J2B3	Streptococcus_phage	6.4e-30	96.0
WP_161501857.1\|1022817_1024161_+	lysin	J7KH48	Streptococcus_phage	3.5e-248	92.2
WP_001872017.1\|1024532_1025039_+	hypothetical protein	NA	NA	NA	NA
WP_000076696.1\|1025197_1025398_+	CsbD family protein	J7KJ36	Streptococcus_phage	7.4e-22	87.9
WP_000356856.1\|1025438_1025609_-	hypothetical protein	A0A286QNA2	Streptococcus_phage	1.1e-07	63.8
WP_161501858.1\|1026024_1026210_+	Paratox	J7KIW4	Streptococcus_phage	2.3e-22	93.1
WP_001056394.1\|1026794_1027406_+	TVP38/TMEM64 family protein	M1Q152	Streptococcus_phage	2.7e-54	54.9
1026354:1026371	attR	NA	NA	NA	NA
WP_000467138.1\|1027442_1028225_-	hypothetical protein	NA	NA	NA	NA
WP_000192685.1\|1028251_1028935_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	3.1e-19	26.6
WP_000312256.1\|1028935_1029304_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_000457960.1\|1029448_1032553_+	DNA polymerase III subunit alpha	A0A0K1Y8J9	Streptomyces_phage	1.1e-114	28.8

DBSCAN-SWA_7

1564009 : 1604235

Streptococcus_phage(22.22%)

transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000191687.1\|1564009_1565185_+\|transposase	IS256-like element ISSag11 family transposase	NA	NA	NA	NA
WP_161501916.1\|1565316_1566810_+	transcriptional regulator	NA	NA	NA	NA
WP_000567083.1\|1566907_1568899_-	excinuclease ABC subunit B	NA	NA	NA	NA
WP_001042318.1\|1568959_1569880_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_000681011.1\|1570062_1572246_+	ABC transporter permease subunit	NA	NA	NA	NA
WP_000818887.1\|1572245_1572986_+	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	5.2e-36	43.3
WP_001292556.1\|1573535_1574813_+	group II intron reverse transcriptase/maturase	NA	NA	NA	NA
WP_001872136.1\|1574992_1575343_+	hypothetical protein	NA	NA	NA	NA
WP_161501917.1\|1575541_1576999_+\|transposase	IS1182-like element IS1563 family transposase	A0A1X9I5T2	Streptococcus_phage	1.3e-203	74.8
WP_000502594.1\|1576999_1577158_-	hypothetical protein	NA	NA	NA	NA
WP_000061658.1\|1577183_1578497_-	GTPase ObgE	NA	NA	NA	NA
WP_000863865.1\|1578557_1578686_-	DUF4044 domain-containing protein	NA	NA	NA	NA
WP_000244049.1\|1578863_1580105_+	aminopeptidase	NA	NA	NA	NA
WP_000865328.1\|1580138_1580717_-	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_000824617.1\|1580810_1582868_-	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_001234920.1\|1582952_1583675_-	rRNA pseudouridine synthase	NA	NA	NA	NA
WP_000468683.1\|1583955_1585434_+\|transposase	IS1182-like element IS1563 family transposase	A0A1X9I5T2	Streptococcus_phage	1.3e-203	74.8
WP_000451355.1\|1585425_1586268_-	aldo/keto reductase	A0A1V0SKP9	Klosneuvirus	3.1e-45	37.2
WP_000159254.1\|1586534_1587209_+	NAD(P)H-dependent oxidoreductase	NA	NA	NA	NA
WP_001116200.1\|1587296_1587689_+	lactoylglutathione lyase	NA	NA	NA	NA
WP_001196763.1\|1587817_1588744_+	glycosyltransferase family 2 protein	V5USA4	Oenococcus_phage	3.4e-85	52.1
WP_000042126.1\|1588872_1590261_+	amino acid permease	NA	NA	NA	NA
WP_000238456.1\|1590344_1590812_-	SsrA-binding protein SmpB	W5RAM5	Staphylococcus_phage	2.6e-41	56.1
WP_000659934.1\|1590814_1593220_-	ribonuclease R	Q0GXV6	Lactococcus_phage	3.7e-91	39.9
WP_000282513.1\|1593332_1593569_-	preprotein translocase subunit SecG	NA	NA	NA	NA
WP_001873241.1\|1593615_1593762_-	50S ribosomal protein L33	NA	NA	NA	NA
WP_000312381.1\|1593758_1594928_-	multidrug efflux MFS transporter	NA	NA	NA	NA
WP_000424347.1\|1596638_1597340_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	4.9e-20	32.3
WP_000930247.1\|1597463_1598057_-	dephospho-CoA kinase	NA	NA	NA	NA
WP_001114605.1\|1598047_1598869_-	DNA-formamidopyrimidine glycosylase	G3MA33	Bacillus_virus	2.5e-23	30.9
WP_132833258.1\|1599952_1600021_+	peptide pheromone SHP2	NA	NA	NA	NA
WP_161501918.1\|1600082_1601675_+	transglutaminase	NA	NA	NA	NA
WP_000039433.1\|1601710_1601887_+	hypothetical protein	NA	NA	NA	NA
WP_025193270.1\|1601936_1602131_-	hypothetical protein	NA	NA	NA	NA
WP_079255206.1\|1602129_1602324_+	hypothetical protein	NA	NA	NA	NA
WP_000191687.1\|1602714_1603890_+\|transposase	IS256-like element ISSag11 family transposase	NA	NA	NA	NA
WP_001873245.1\|1603980_1604235_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_8

1664781 : 1675513

Streptococcus_phage(84.62%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000767483.1\|1664781_1665609_+	exodeoxyribonuclease III	M1PSC0	Streptococcus_phage	9.6e-124	77.7
WP_000287943.1\|1665648_1666005_-	arsenate reductase family protein	M1PLC0	Streptococcus_phage	5.2e-42	72.6
WP_161501922.1\|1666006_1666483_-	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	3.5e-38	49.7
WP_000232148.1\|1666539_1667721_-	phosphoglycerate dehydrogenase	M1NSB9	Streptococcus_phage	2.6e-167	75.3
WP_001167085.1\|1667783_1668332_-	acetyltransferase	M1PSC3	Streptococcus_phage	1.1e-54	58.4
WP_161501923.1\|1668399_1669491_-	3-phosphoserine/phosphohydroxythreonine transaminase	M1Q1P2	Streptococcus_phage	8.7e-165	77.9
WP_000603276.1\|1669623_1670259_+	copper homeostasis protein CutC	NA	NA	NA	NA
WP_001873251.1\|1670528_1671392_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	4.1e-109	70.0
WP_000358198.1\|1671397_1671724_-	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	3.2e-30	61.1
WP_000364547.1\|1671753_1672617_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	2.5e-74	49.7
WP_000715592.1\|1672636_1673272_-	dTMP kinase	M1PSC7	Streptococcus_phage	2.8e-67	61.1
WP_001144243.1\|1673360_1674020_-	CBS domain-containing protein	M1NSC5	Streptococcus_phage	3.6e-65	56.0
WP_000178146.1\|1674038_1674749_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.7e-18	28.5
WP_001185985.1\|1674748_1675513_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	2.6e-14	24.8

DBSCAN-SWA_9

2247755 : 2258195

Streptococcus_phage(37.5%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_161501970.1\|2247755_2248430_-	transglycosylase SLT domain-containing protein	Q4Z8Z7	Staphylococcus_phage	6.8e-27	54.3
WP_000029069.1\|2248535_2249075_-	LysM peptidoglycan-binding domain-containing protein	A0A249XZV3	Enterococcus_phage	1.3e-17	46.4
WP_000359358.1\|2249290_2250085_-	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
WP_161501971.1\|2250077_2250920_-	energy-coupling factor transporter ATPase	A0A076FI99	Aureococcus_anophage	8.6e-11	31.5
WP_000181757.1\|2250895_2251735_-	energy-coupling factor transporter ATPase	G9BWD6	Planktothrix_phage	3.5e-20	30.0
WP_000239225.1\|2251734_2252277_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
WP_161501972.1\|2252399_2253683_-	insulinase family protein	A0A2H4UVM3	Bodo_saltans_virus	1.6e-05	23.6
WP_000706188.1\|2253684_2254929_-	insulinase family protein	A0A1X9I714	Streptococcus_phage	3.7e-87	41.3
WP_000384869.1\|2255167_2255521_+	S4 domain-containing protein YaaA	A0A1X9I5V8	Streptococcus_phage	7.2e-20	61.8
WP_000264870.1\|2255523_2256633_+	DNA replication/repair protein RecF	NA	NA	NA	NA
WP_031463830.1\|2256740_2258195_+\|transposase	IS1182-like element IS1563 family transposase	A0A1X9I5T2	Streptococcus_phage	1.3e-203	74.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP026082

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection