CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_AP022603	Mycolicibacterium fallax strain JCM 6405	20 crisprs	WYL,DEDDh,csa3,cas3	3	9	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_AP022603_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022603_1

235586-236023

Orphan

Consensus_repeat	Method
GGCCGCNACCAAGGCNNC	CRT

7 spacers

The CRISPR arrays of NZ_AP022603_1

>merge|NZ_AP022603|1|235586-236023|CRT
GGCGCCGGCCAAGGCTGCCAAGAAGACGGCGGCCAAGAAGACCGCCGCCAAGAAGACCGCCGCCAAGAAGACCGCCGCCAAGGCCGCACCGGCCAAGGCCGCCACCAAGTCGGTGGCGAAGGCCGCCACCAAGGCGCCCACCAAGAAGGCCGCGGTGCAGAAGGCCGCTCCGGCCAAGACCACCCGGGCCGCGACCAAGGCGCCGGCCAAGACTGCGACGAAGGCCGCCACCAAGGCGCCGGCCAAGGCCGCGACCAAGGCGCCCGCCAAGAAGGCCGCGGTGCAGAAGGCCGCTCCGGCCAAGACCACTCGGGCCGCGACCAAGGCGCCGGCCAAGACCGCGACCAAGGCAGCCACCAAGACGGCCAGCAAGGCTCCGGCCAAGAAGGCCGCGGTGAAGAAGGCCGCTCCGGCCAAGAAGGCCGCGACCAAGGCTCC

>NZ_AP022603|1|1|235586-236023|CRT
GGCGCCGGCCAAGGCTGC	CAAGAAGACGGCGGCCAAGAAGACCGCCGCCAAGAAGACCGCCGCCAAGAA
GACCGCCGCCAAGGCCGC	ACCGGCCAAGGCCGCCACCAAGTCGGTGGCGAA
GGCCGCCACCAAGGCGCC	CACCAAGAAGGCCGCGGTGCAGAAGGCCGCTCCGGCCAAGACCACCCG
GGCCGCGACCAAGGCGCC	GGCCAAGACTGCGACGAAGGCCGCCACCAAGGCGCCGGCCAA
GGCCGCGACCAAGGCGCC	CGCCAAGAAGGCCGCGGTGCAGAAGGCCGCTCCGGCCAAGACCACTCG
GGCCGCGACCAAGGCGCC	GGCCAAGACCGCGACCAA
GGCAGCCACCAAGACGGC	CAGCAAGGCTCCGGCCAAGAAGGCCGCGGTGAAGAAGGCCGCTCCGGCCAAGAA
GGCCGCGACCAAGGCTCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022603.1\|WP_085093886.1\|247269_247956_+\|uracil-DNA-glycosylase	unknown	unknown	gnl\|CDD\|235376
NZ_AP022603.1\|WP_085093663.1\|246258_247221_+\|thiamine-phosphate-kinase	unknown	unknown	gnl\|CDD\|235583
NZ_AP022603.1\|WP_109750427.1\|241103_242207_+\|cystathionine-gamma-lyase	unknown	unknown	gnl\|CDD\|236061
NZ_AP022603.1\|WP_109750428.1\|242263_243355_+\|D-alanine--D-alanine-ligase	unknown	unknown	gnl\|CDD\|234993
NZ_AP022603.1\|WP_085093629.1\|225073_226276_+\|DUF2236-domain-containing-protein	unknown	unknown	gnl\|CDD\|378343
NZ_AP022603.1\|WP_085093633.1\|227562_228834_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|367155
NZ_AP022603.1\|WP_085093651.1\|237122_239291_-\|RNA-degradosome-polyphosphate-kinase	unknown	unknown	gnl\|CDD\|235469
NZ_AP022603.1\|WP_085093643.1\|233061_234450_+\|3-isopropylmalate-dehydratase-large-subunit	unknown	unknown	gnl\|CDD\|235490
NZ_AP022603.1\|WP_109750409.1\|226334_227525_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341028
NZ_AP022603.1\|WP_085093635.1\|228986_229781_+\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223257
NZ_AP022603.1\|WP_085093659.1\|243711_245532_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173412
NZ_AP022603.1\|WP_085093661.1\|245599_246166_-\|DUF3515-domain-containing-protein	unknown	unknown	gnl\|CDD\|378794
NZ_AP022603.1\|WP_085093641.1\|232255_232957_-\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_AP022603.1\|WP_085093645.1\|234464_235061_+\|3-isopropylmalate-dehydratase-small-subunit	unknown	unknown	gnl\|CDD\|179314
NZ_AP022603.1\|WP_085093637.1\|229777_231247_+\|glutamate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234953
NZ_AP022603.1\|WP_085093639.1\|231711_232209_-\|PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274679
NZ_AP022603.1\|WP_085093649.1\|236140_237079_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239645
NZ_AP022603.1\|WP_085093653.1\|240084_241095_+\|NAD(P)-dependent-glycerol-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|234629
NZ_AP022603.1\|WP_085093627.1\|224371_224986_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_AP022603.1\|WP_109750411.1\|239305_239986_-\|2-phospho-L-lactate-guanylyltransferase	unknown	unknown	gnl\|CDD\|274643

Protein	Function_ID	Function_description	E-value
NZ_AP022603.1\|WP_085093886.1\|247269_247956_+\|uracil-DNA-glycosylase	gnl\|CDD\|235376	PRK05254, PRK05254, uracil-DNA glycosylase; Provisional.	2.72063e-128
NZ_AP022603.1\|WP_085093663.1\|246258_247221_+\|thiamine-phosphate-kinase	gnl\|CDD\|235583	PRK05731, PRK05731, thiamine monophosphate kinase; Provisional.	3.36865e-115
NZ_AP022603.1\|WP_109750427.1\|241103_242207_+\|cystathionine-gamma-lyase	gnl\|CDD\|236061	PRK07582, PRK07582, cystathionine gamma-lyase; Validated.	1.89827e-179
NZ_AP022603.1\|WP_109750428.1\|242263_243355_+\|D-alanine--D-alanine-ligase	gnl\|CDD\|234993	PRK01966, ddl, D-alanine--D-alanine ligase.	2.95298e-175
NZ_AP022603.1\|WP_085093629.1\|225073_226276_+\|DUF2236-domain-containing-protein	gnl\|CDD\|378343	pfam09995, DUF2236, Uncharacterized protein conserved in bacteria (DUF2236). This domain, found in various hypothetical bacterial proteins, has no known function. This family contains a highly conserved arginine and histidine that may be active site residues for an as yet unknown catalytic activity.	6.51648e-20
NZ_AP022603.1\|WP_085093633.1\|227562_228834_-\|HNH-endonuclease	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	3.5567e-14
NZ_AP022603.1\|WP_085093651.1\|237122_239291_-\|RNA-degradosome-polyphosphate-kinase	gnl\|CDD\|235469	PRK05443, PRK05443, polyphosphate kinase; Provisional.	0
NZ_AP022603.1\|WP_085093643.1\|233061_234450_+\|3-isopropylmalate-dehydratase-large-subunit	gnl\|CDD\|235490	PRK05478, PRK05478, 3-isopropylmalate dehydratase large subunit.	0
NZ_AP022603.1\|WP_109750409.1\|226334_227525_+\|MFS-transporter	gnl\|CDD\|341028	cd17475, MFS_MT3072_like, Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily. This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.2482e-72
NZ_AP022603.1\|WP_085093635.1\|228986_229781_+\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	1.63452e-99
NZ_AP022603.1\|WP_085093659.1\|243711_245532_+\|hypothetical-protein	gnl\|CDD\|173412	PTZ00121, PTZ00121, MAEBL; Provisional.	0.00469921
NZ_AP022603.1\|WP_085093661.1\|245599_246166_-\|DUF3515-domain-containing-protein	gnl\|CDD\|378794	pfam12028, DUF3515, Protein of unknown function (DUF3515). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 166 to 214 amino acids in length. This protein has a conserved RCG sequence motif.	2.10325e-51
NZ_AP022603.1\|WP_085093641.1\|232255_232957_-\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	1.51836e-54
NZ_AP022603.1\|WP_085093645.1\|234464_235061_+\|3-isopropylmalate-dehydratase-small-subunit	gnl\|CDD\|179314	PRK01641, leuD, 3-isopropylmalate dehydratase small subunit.	1.16761e-117
NZ_AP022603.1\|WP_085093637.1\|229777_231247_+\|glutamate--tRNA-ligase	gnl\|CDD\|234953	PRK01406, gltX, glutamyl-tRNA synthetase; Reviewed.	0
NZ_AP022603.1\|WP_085093639.1\|231711_232209_-\|PPOX-class-F420-dependent-oxidoreductase	gnl\|CDD\|274679	TIGR03618, Rv1155_F420, PPOX class probable F420-dependent enzyme. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity].	4.17347e-29
NZ_AP022603.1\|WP_085093649.1\|236140_237079_-\|NUDIX-hydrolase	gnl\|CDD\|239645	cd03673, Ap6A_hydrolase, Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most preferred substrate, hydrolyzes to produce two ATP molecules, which is a novel hydrolysis mode for Ap6A. These results indicate that Ap6A hydrolase is a diadenosine polyphosphate hydrolase. It requires the presence of a divalent cation, such as Mn2+, Mg2+, Zn2+, and Co2+, for activity. Members of the Nudix superfamily are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site.	2.26153e-47
NZ_AP022603.1\|WP_085093653.1\|240084_241095_+\|NAD(P)-dependent-glycerol-3-phosphate-dehydrogenase	gnl\|CDD\|234629	PRK00094, gpsA, NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.	1.83822e-170
NZ_AP022603.1\|WP_085093627.1\|224371_224986_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.50769e-06
NZ_AP022603.1\|WP_109750411.1\|239305_239986_-\|2-phospho-L-lactate-guanylyltransferase	gnl\|CDD\|274643	TIGR03552, F420_cofC, 2-phospho-L-lactate guanylyltransferase. Members of this protein family are the CofC enzyme of coenzyme F420 biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	7.87757e-48

>NZ_AP022603.1|WP_085093645.1|234464_235061_+|3-isopropylmalate-dehydratase-small-subunit
MEAFHSHTGIAVPLRRSNVDTDQIIPAVYLKRVTRTGFEDGLFASWRNDPSFILNQKPFDRGSVLVAGPDFGTGSSREHAVWALMDYGFRVVISSRFADIFRGNAGKAGLVAAQVSQDDVELLWKLIEQRPGLEVTVNLADRTISAETAVLPFTIDDYTAWRLQEGLDDIGLTLRKLDAIEAYEQRRPSWKPHTLPVP
>NZ_AP022603.1|WP_085093643.1|233061_234450_+|3-isopropylmalate-dehydratase-large-subunit
MAEKVWADHVVATEPGEPDLIYIDLHLVHEVTSPQAFDGLRMAGRPVHRPDLTIATEDHNVPTIDIDKPIADPVSRTQVETLRRNCAEFGIRLHQMGDRDQGIVHIIGPQLGLTQPGMTIVCGDSHTSTHGAFGSIAMGIGTSEVEHVLATQTLSLKPFKTMAVNVDGELPPGVSAKDIILAVIAEIGTGGGQGHVIEYRGSAIEALSMEGRMTICNMSIEAGARAGMVAPDETTYAYLQGRRHAPTGADWDAAVAAWNGLRTDPGAVFDTEVRIDAASLSPFVTWGTNPGQGVPLSATVPDPETMLNDAEKVAAEKALAYMDLAAGTPMRDIPVDTVFVGSCTNGRIEDLRVVAEVLRDRRVADGVRMLIVPGSVGVREQAESEGLGAIFEAAGAEWRQAGCSMCLGMNPDQLAPGERSASTSNRNFEGRQGKGSRTHLVSPEVAAATAVRGTLSSPADLA
>NZ_AP022603.1|WP_085093641.1|232255_232957_-|IclR-family-transcriptional-regulator
MRQNSGIGVLDKAVGVLHAVAESPCGLAELCERTGLPRATAHRLAAGLEIHRLLARDGDGRWCPGPALVELSANVSDPLLGAAAAVLPRLREITGESVQLYRREGTARVCVAALEPPAGLRDTVPVGAHLPLTAGSGAKVLLAYADHRTQQSVLPNAKFTDRVLAEVRRRGWAQSAAERESGVASVAAPVRDHAGSVVAAVSVSGPIDRMGRRPGERWAADLVAAADALTRRL
>NZ_AP022603.1|WP_085093639.1|231711_232209_-|PPOX-class-F420-dependent-oxidoreductase
MGSKQRQQIVMSDDEITDFVTHSRTGTLATVGPDGQPHLVAMWYGIVDGEIWLETKAKSQKAVNLRRDARYTFLIEDGQTYDTLRGVSFEGTAELVDDAEAVFRVGISVWERYTGPYTEELRPAVEMILNKRIGLRLLPTRTRSWDHRKLGLPAMPLSGSTAPQS
>NZ_AP022603.1|WP_085093637.1|229777_231247_+|glutamate--tRNA-ligase
MTVRVRFCPSPTGTPHVGLIRTALFNWAYARHTGGAFVFRIEDTDAARDSEESYLALLDALRWLGMDWDEGPEVGGPYGPYRQSQRRDSYLEVVQKLLDAGEAYEAYSTAEEVEARHLAAGRNPKLGYDNFDRDLTDAQRAEFRAAGRSPVVRLRMPDADITWTDLVRGQTTFPAGSVPDFALTRGSGDPLYTLVNPVDDAMMKITHVLRGEDLLPSTPRQIALYQALIRIGVAEAVPQFAHLPSVLGDGNKKLSKRDPQSNLFLHRDRGFIPEGLLNYLALLGWSIADDRDLFSLAEMVEAFDVADVNSNPARFDQKKADAINAEHIRRLGAEEFADRLGAYLLAHGHHLDLTPAQFAEAAELVQTRIVVLGDAWPLLKFLDDEHYWIEEKAAAKELSAAAAPVLDATLAALDPVGDWTAEAIEAALREALIEGLELKPRKAFGPIRVAVTGSTVSPPLYESMELLGRDRSLSRLRQARANLPAEQAD
>NZ_AP022603.1|WP_085093635.1|228986_229781_+|fumarylacetoacetate-hydrolase-family-protein
MRLGRVATPAGVVFVVIEGDGDDAVAKEIAEQYLSRNPTFTGRSWPMADVRLLAPILASKVICMGKNYAAHAREMGGEAPEDPVIFLKPNTAIIGPGVPIQLPHDANPVHHEGELAIVIERPCKDVPADRAAQYILGYTIANDVSARDQQQKDGQWMRAKGHDTFCPVGPWIETAVDPSDLDIRTEVNGQPRQDSNTAFLLHDVGAIIEWVSAVMTLLPGDLILTGTPEGVGPIEDGDTVAITIEGIGTLSNPVVRKPDPEGKP
>NZ_AP022603.1|WP_085093633.1|227562_228834_-|HNH-endonuclease
MFELATSGVDLQDEAALVSGIAELERLKSQAAATQARLSAQLATVRHDAEVAAGVPAARRGRGLAAEIALARHDSPNRGNRHLGFAQALVHEMPHTLKALETGALSEWRATLIVRESACLEVGDRATLDAELCADPGALAGLGDGRIAAAAKAIAYRLDPHAVVDRAVKAEADRCVTIRPAPDNMVYLTALLPMAKGVSVYAALRRAADGNGDGRTRGQLMADALIERITGRPAQTPEPIAVSLVLSDQTLVGGNDPAVVPGFGPVPADIARSLIAAALDTPEVRATLRRLYAHPGSGALVAMESRSRLFPKGLATLIRFRDHSCRTPYCDAPIRHTDHITPATRGGPTSERNGQGTCEACNHNKQAAGWLVAPIDADRHTTELTTPTGHHYRSTAPPVLLGRKPLSPMEKCLFDTLRQQQAA
>NZ_AP022603.1|WP_109750409.1|226334_227525_+|MFS-transporter
MDIDAIGTARRWSILAIALSATLFSNVFINGMAFLIPTLHSQRGLDLAHAGLVSAMPAFGMVMTLIVWGYVVDRIGERTVLTVGSALTAAAGFAAAAADSLPAVQVWLFLGGMAAASSNSASARMVVGWFPPQTRGLAMGIRQTAQPLGVGLGALVIPQIAATHGVSAALLFPAAVCAVAAVLSGVGLLDPPRPDRADAHPDELANPYRGSNTLGRIHLVSVLLVVPQALVWTFTLVWLIADRGWSAPAAGAVVTAAQLLGAAGRIAAGRWSDRVGSRLRPIRVIAAAAAVSMALLAITEVFDSPWSVVIMLVASMVTVSDNGLAFTAIAEIAGPFWSGRALGVQNTSQLFAAGVVPPAFGALITSAGYAAAFGVCAVFPLLALPFIPVAADPLRD
>NZ_AP022603.1|WP_085093629.1|225073_226276_+|DUF2236-domain-containing-protein
MGSTAPKLPNPAALSDFPFNVFVRLLADGDVRATAAQRGSFRRFTDLGDPLADDVVAMIAAMPPRLGRAMFETAVERGIDAVPDPPPELVAFFAQVDDQPYWLDYDKLALAARVSMRTGLVGIGLALPGLALTGGYLAAKADKPLVGTGDLHRMAPRRLNETATWYIDVTSPGGLRRFAPGFTGTLRVRLMHAQVRAAMHRRADWDYDNWDAPINQVQLAGTLMLFSLANLAGCQAMGMRFSDRERDAVYHFWRYVGILMGVHPELVPTCEADTWRLFWLEADTEFAPDEDSARLAAALHDRREDGWQTEAARAYLSAYSRLMLGRSNADRLGLADNKPLQAAVVATAAVNRVFDYHRVVPGMTRLAEEMGQRARRGFIARGLKASGGDRSYRRHDSLTE
>NZ_AP022603.1|WP_085093627.1|224371_224986_-|TetR/AcrR-family-transcriptional-regulator
MSARARTYGGATAGERQARRRGALIDAATDVIAESGVAGLTVRGVCVAARLNDRYFYESFANTDDLLVAAFDTQMTAAAAEMVAALSASPPDPLLRARAAIASGLGYLTADPRRGHLLIESQATEALRARRREVIGTLAAIMAEQGRALLPIENPLDTDIDLAAWTLVAGGLDLVTGWLRGEVEVDRAHLEEFLVAMVTARRLA
>NZ_AP022603.1|WP_085093649.1|236140_237079_-|NUDIX-hydrolase
MPSETHDHRGKSGHRTGPVLAAGAVLWRPGADGAPEVAVVHRPRYDDWSLPKGKVDKGESEPATAVREIFEETGFRSRLGRRLGTARYLLNGSGEKKVTYWAARADDGDFLANREVDRLEWLPVAAAADRLGYPQDRKVLRRFARLPHDTHTLLVVRHATAGRKSRYHGDDRCRPLDANGRTQAEAMVPLLLAFGAERLHAADRTRCHQTLEPLAEALRVAIENEPALTEEAYADNRKAARHRFLQIAELPGTRAVCSQGKVIPHIIDWWCERDAVSADKSRNRKGSIWVLSLHNGRLIAADHIASPLPVRN
>NZ_AP022603.1|WP_085093651.1|237122_239291_-|RNA-degradosome-polyphosphate-kinase
MVNDRGVTETDATAHTITGDGAQPADGDSEALLAAAVFEDLPEDRYLNRELSWLDFNNRVLQLAENTSLPLLERAKFLAIFASNLDEFYMVRVAGLKRRDEMGLSVRSADGLSPREQLQRIGERGQQISVRHAKVFMESVRPALAEQGILVVTWADLDGSDRERLSKYFMEQVFPVLTPLAVDPAHPFPFVSGLSLNMAITVRQPEDGTQHFARIKVPDNVARFVKLQDAQREDGHHNVRFLPMEELIAAFLPVLFPGMEIVEQHAFRITRNADMEVEEDRDEDLLQALERELARRRFGKPVRLEVADDMTENMLELLLRELDVDPDDVVTVPGLLDLTALWQVYGVDRPKLKDRPFVPSTPAMFSESAKSLFSNLREGDLLLHHPYDSFSTTVQRFIEMAAADPDVLAIKQTLYRTSGDSPIVNALIDAAASGKQVVALVELKARFDEQANIKWARKLEQAGVHVVYGLIGLKTHCKTALVVRREGSSIKRYCHIGTGNYNPKTARLYEDVGLLTASPEIGADLTDLFNTLTGYSRKDTYRNLLVAPQGIRRGIVERIDREIAAARRGEDARIRMKMNALVDEQVIDALYRASLSGVKVEIVVRGICALRPGAEGFSENITVRSILGQFLEHSRIIHFNAIDEFWIGSADMMHRNLDRRVEVLVQVKDPRLSAQLDTVFNSALDPATLCWELGSDGAWTPSPHDGRPGRDHQVAMMASRHS
>NZ_AP022603.1|WP_109750411.1|239305_239986_-|2-phospho-L-lactate-guanylyltransferase
MASMSRTPPGIPGDTAVVIAVKRLAAAKTRLSAQFSADAREELVLAMLLDTAAAATRVLGAAAVTVVTPDRAVTSAVADLGMLALADPTPPGHPDPLNNALRAAVAHITARGARPRNVVILQGDLPALRSSELADALDRAEAHPRSFVADRHRTGTAALFAFGVPCEPHFGADSASRHRNSGAVELTGDWPGLRCDIDTSEDLAAAARIGLGPATRAVDERSSTRS
>NZ_AP022603.1|WP_085093653.1|240084_241095_+|NAD(P)-dependent-glycerol-3-phosphate-dehydrogenase
MAGTVRTATVMGAGAWGTALAKVLADGGIDVRLWARRPELAEAINATARNEDYLPGIALPPGVRATSDPAAALGGVTTVLLGVPAQQLRTNLEQWVPLLDPDATLVSLAKGIELGTLMRMTQVIQQVSGFDINQIAVLSGPNLASEVAEGQPAATVVACTDSGRAVELQRALNTGYFRPYTNTDVVGAEIGGACKNVIALACGMANGIGLGENTAAAIITRGLAEIMRLGMALGAQPTTLAGLAGVGDLVATCTSRHSRNFSFGRRLGQGMTIEEARKAGEGHVAEGFASCQSVLALASSYGVEMPLTDAVARVCHHGLSVNQAIALLLGRRTKPE
>NZ_AP022603.1|WP_109750427.1|241103_242207_+|cystathionine-gamma-lyase
MPRRYGDSTRTLKAATPPAQPGRPVAPGPVPVSAYHLSADESAELDTYGRASNPTWRQLEAGIAELEGAAEALVFGSGMAAVTAALRVLVRPGSVLVVPADGYYQVRRFAAESLAPLGVTVVEADHAEIFEAAERADVVLAETPVNPTLDVVDLHRLARLCRGRGARLIVDNTAATPLAQQPLACGADLVVASATKALSGHSDLLGGYLAASRGELMAALARERLLTGAVLGAFDTWLLLRSLAGAGLRYGRQCANAQALATMLTGHPAVRSVRYPGLPDHPGHSVACAQMQHFGSLVSVELADAAAVHALVARSDLLVASTSFGGMHTSVDRRARWGDPVGDGFARISLGIEDTDDLLADFGRALG
>NZ_AP022603.1|WP_109750428.1|242263_243355_+|D-alanine--D-alanine-ligase
MRVAVVFGGRSSEHAISCVSAGSILRNLDPARFEVIPVGITPAGCWVLSTATAEKLAIVDGQLPEVTTDSGTALMLAADPTRRGELLSVGRDPGAVLASVDVVFPVLHGPYGEDGTIQGLLELAGVPYVGAGVLASAAGMDKEFTKKLLAADGLPIGDYVVLRPDRAALSDAEVARLGFPMFVKPARGGSSIGVSRVTDAAGLAAAIAEARAHDPKVIVEAAVIGREVECGVLEFPDGRLGASALGEIRVAADGGPADGFYDFATKYLVDAAELDVPADVEPAMADRIRELAIRAFRAIDGQGLARVDFFLTADGPVINEINTMPGFTTISMYPRMWAASGVDYPALLAAMVDTAVARGTGLR
>NZ_AP022603.1|WP_085093659.1|243711_245532_+|hypothetical-protein
MQHALQTGADDGSGPAVPRALSRKRRLAVAGVAAIGASAIAITPVAAGPNLVAAQHRDVALTAGYTPNPLVTDSPLDVYGGILGITGENLTGLGESFMANPFPLLSQVAANQLGYADRIGTAFEKIQTNMDGFFAEGTVKPGQAEHDENGYLIKGNRVGAGNGYVYGTNAMIALQKGDIFRAYQEFNALVLYSNTVATTQLGGLIMDTTVTTKWYNAPDGALTTDAVHYKDAAGNVVAADTDGAQAVPNTVATLADGTPYTTTSTNRGIPGQLVQNVSNAFSALANKTNIQSGLFYSSFAAFAGVPYEVSRNVAELVQAIQAGEPETAINVLVNSPGMTINALFNGFDYSATDKETCTGGNACVPVVSWPGLFAPLGAPKSDGKTPQHPGGLIYQALTGMGLSVGKAIDNDPETERSLFSGLNASSLTSGLNLKSLTPGGNAKVEVAKVEGAKDEVGKDELVTKVDEAGNSKGNDTAVTTLRSTTDTPEAAVSAPERVVDAKKELSDTAAEAKDATDAVTKTVSKSEQRRAKAQERIAKVNDRITTSIQKVTDGVKKATGLTKSTKSESTKSESSGSSKDSGGGSSSGGSSGGSSKGGSSSGGSDS
>NZ_AP022603.1|WP_085093661.1|245599_246166_-|DUF3515-domain-containing-protein
MTDDDESTPAKPLVEPADGPPRPVVAIALVLGVAAVLTIIVIALNRQPSQGPVPVATLPAPQAGSADCTELLAAAPQSLDDYRRAEILEPAPAGVLAWRSDTGQLPVIMRCGLDRPGDFVVGVPLQVVNDVQWFRVADAGLVSWFAVDRPVYIALTLPDGSGPGPIQQLSVAIAESLPARPIDPGPPR
>NZ_AP022603.1|WP_085093663.1|246258_247221_+|thiamine-phosphate-kinase
MTEGPTLGELGEFAVIDAITAGRRHGDAVRVGPGDDAAVLDAPDGRVVASTDMLVQGRHFRLDWSSPEQVGRKAIAQNAADIEAMGAVPTGFLVAFGAPVDTPASAVTALSDGLSAEAARAGASIIGGDLVASPQWTVSVTALGDLAGRPAVLRSGASAGDVVAVAGELGRSGAGYALLDAGAAEPALAALVDRHLVPQPPYGQGARAARAGATAMTDVSDGLIIDLRQLAAASGVGIDLHTARLAADRDALTAAAVALGADPWAWIFGGGEDHALVACFPAAAVLPQGWRLIGAVTAEHDGVTVDGGGWTGRPGWDSFG
>NZ_AP022603.1|WP_085093886.1|247269_247956_+|uracil-DNA-glycosylase
MTSGPRPLAELIDPGWASALAPVGDRVAELGTFLRGELGQGRGYLPAGENVLRAFTFPFDAVRVLIVGQDPYPTPGHAMGLSFSVAPEVQPLPRSLVNIFTEYSADLGLPKPSNGDLTPWARRGVMLLNRVLTVSPGTPASHRGKGWEAVTECAIRALAERPAPYVAILWGRDAGTLKPMLGPRCAVIESPHPSPLSASRGFFGSRPFSRANALLREAGAEPVDWQLP

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Crispr_ID: NZ_AP022603_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022603_2

268112-268190

Orphan

Consensus_repeat	Method
GCACTGCTGGGCTGAGCGCGAAGCGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022603_2

>merge|NZ_AP022603|2|268112-268190|CRISPRCasFinder
GCACTGCTGGGCTGAGCGCGAAGCGCGAGGCCCATGCGGTGCGCATGTCACTGCACTGCTGGGCTGAGCGCGAAGCGCG

>NZ_AP022603|2|1|268112-268190|CRISPRCasFinder
GCACTGCTGGGCTGAGCGCGAAGCGCG	AGGCCCATGCGGTGCGCATGTCACT
GCACTGCTGGGCTGAGCGCGAAGCGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022603.1\|WP_085093715.1\|280312_281185_-\|D-alanyl-D-alanine-carboxypeptidase	unknown	unknown	gnl\|CDD\|224600
NZ_AP022603.1\|WP_085093695.1\|262809_263088_+\|acylphosphatase	unknown	unknown	gnl\|CDD\|237712
NZ_AP022603.1\|WP_085093709.1\|275906_277478_+\|signal-recognition-particle-protein	unknown	unknown	gnl\|CDD\|236780
NZ_AP022603.1\|WP_085093683.1\|257395_258466_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NZ_AP022603.1\|WP_085093892.1\|268193_270500_-\|FdhF/YdeP-family-oxidoreductase	unknown	unknown	gnl\|CDD\|273765
NZ_AP022603.1\|WP_085093685.1\|258799_259276_+\|pantetheine-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|234674
NZ_AP022603.1\|WP_085093703.1\|271669_273034_+\|ammonium-transporter	unknown	unknown	gnl\|CDD\|223083
NZ_AP022603.1\|WP_085093711.1\|277506_278574_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238624
NZ_AP022603.1\|WP_085093689.1\|260693_261398_+\|ribonuclease-III	unknown	unknown	gnl\|CDD\|234633
NZ_AP022603.1\|WP_085093705.1\|273067_273406_+\|P-II-family-nitrogen-regulator	unknown	unknown	gnl\|CDD\|223424
NZ_AP022603.1\|WP_085093707.1\|273438_275871_+\|[protein-PII]-uridylyltransferase	unknown	unknown	gnl\|CDD\|235123
NZ_AP022603.1\|WP_085093701.1\|270595_271462_-\|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	unknown	unknown	gnl\|CDD\|234823
NZ_AP022603.1\|WP_085093697.1\|263152_266737_+\|chromosome-segregation-protein-SMC	unknown	unknown	gnl\|CDD\|274008
NZ_AP022603.1\|WP_085093717.1\|281278_281698_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|379275
NZ_AP022603.1\|WP_085093890.1\|260161_260701_+\|DUF177-domain-containing-protein	unknown	unknown	gnl\|CDD\|224317
NZ_AP022603.1\|WP_085093713.1\|279367_280225_-\|D-alanyl-D-alanine-carboxypeptidase	unknown	unknown	gnl\|CDD\|224600
NZ_AP022603.1\|WP_085093693.1\|262392_262806_+\|OsmC-family-protein	unknown	unknown	gnl\|CDD\|224679
NZ_AP022603.1\|WP_085093687.1\|259363_260101_+\|DivIVA-domain-containing-protein	unknown	unknown	gnl\|CDD\|226127
NZ_AP022603.1\|WP_085093888.1\|256822_257383_+\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	unknown	unknown	gnl\|CDD\|223813
NZ_AP022603.1\|WP_085093691.1\|261397_262303_+\|bifunctional-DNA-formamidopyrimidine-glycosylase/DNA-(apurinic-or-apyrimidinic-site)-lyase	unknown	unknown	gnl\|CDD\|234899

Protein	Function_ID	Function_description	E-value
NZ_AP022603.1\|WP_085093715.1\|280312_281185_-\|D-alanyl-D-alanine-carboxypeptidase	gnl\|CDD\|224600	COG1686, DacC, D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane].	7.26081e-60
NZ_AP022603.1\|WP_085093695.1\|262809_263088_+\|acylphosphatase	gnl\|CDD\|237712	PRK14422, PRK14422, acylphosphatase; Provisional.	1.36174e-48
NZ_AP022603.1\|WP_085093709.1\|275906_277478_+\|signal-recognition-particle-protein	gnl\|CDD\|236780	PRK10867, PRK10867, signal recognition particle protein; Provisional.	0
NZ_AP022603.1\|WP_085093683.1\|257395_258466_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	5.21972e-10
NZ_AP022603.1\|WP_085093892.1\|268193_270500_-\|FdhF/YdeP-family-oxidoreductase	gnl\|CDD\|273765	TIGR01701, Hypothetical_protein_Rv2900c/MT2968/Mb2924c., oxidoreductase alpha (molybdopterin) subunit. This model represents a well-defined clade of oxidoreductase alpha subunits most closely related to a group of formate dehydrogenases including the E. coli FdhH protein (TIGR01591). These alpha subunits contain a molybdopterin cofactor and generally associate with two other subunits which contain iron-sulfur clusters and cytochromes. The particular subunits with which this enzyme interacts and the substrate which is reduced is unknown at this time. In Ralstonia, the gene is associated with the cbb operon, but is not essential for CO2 fixation.	0
NZ_AP022603.1\|WP_085093685.1\|258799_259276_+\|pantetheine-phosphate-adenylyltransferase	gnl\|CDD\|234674	PRK00168, coaD, phosphopantetheine adenylyltransferase; Provisional.	1.04079e-91
NZ_AP022603.1\|WP_085093703.1\|271669_273034_+\|ammonium-transporter	gnl\|CDD\|223083	COG0004, AmtB, Ammonia permease [Inorganic ion transport and metabolism].	4.643e-145
NZ_AP022603.1\|WP_085093711.1\|277506_278574_+\|amidohydrolase-family-protein	gnl\|CDD\|238624	cd01299, Met_dep_hydrolase_A, Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	8.25571e-73
NZ_AP022603.1\|WP_085093689.1\|260693_261398_+\|ribonuclease-III	gnl\|CDD\|234633	PRK00102, rnc, ribonuclease III; Reviewed.	4.42582e-114
NZ_AP022603.1\|WP_085093705.1\|273067_273406_+\|P-II-family-nitrogen-regulator	gnl\|CDD\|223424	COG0347, GlnK, Nitrogen regulatory protein PII [Amino acid transport and metabolism].	1.39909e-52
NZ_AP022603.1\|WP_085093707.1\|273438_275871_+\|[protein-PII]-uridylyltransferase	gnl\|CDD\|235123	PRK03381, PRK03381, PII uridylyl-transferase; Provisional.	0
NZ_AP022603.1\|WP_085093701.1\|270595_271462_-\|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	gnl\|CDD\|234823	PRK00724, PRK00724, formate dehydrogenase accessory sulfurtransferase FdhD.	1.77415e-103
NZ_AP022603.1\|WP_085093697.1\|263152_266737_+\|chromosome-segregation-protein-SMC	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0
NZ_AP022603.1\|WP_085093717.1\|281278_281698_+\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|379275	pfam13577, SnoaL_4, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	7.40356e-35
NZ_AP022603.1\|WP_085093890.1\|260161_260701_+\|DUF177-domain-containing-protein	gnl\|CDD\|224317	COG1399, COG1399, Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only].	2.01673e-38
NZ_AP022603.1\|WP_085093713.1\|279367_280225_-\|D-alanyl-D-alanine-carboxypeptidase	gnl\|CDD\|224600	COG1686, DacC, D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane].	1.74578e-63
NZ_AP022603.1\|WP_085093693.1\|262392_262806_+\|OsmC-family-protein	gnl\|CDD\|224679	COG1765, COG1765, Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones].	1.12378e-22
NZ_AP022603.1\|WP_085093687.1\|259363_260101_+\|DivIVA-domain-containing-protein	gnl\|CDD\|226127	COG3599, DivIVA, Cell division initiation protein [Cell division and chromosome partitioning].	2.217e-35
NZ_AP022603.1\|WP_085093888.1\|256822_257383_+\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	gnl\|CDD\|223813	COG0742, COG0742, N6-adenine-specific methylase [DNA replication, recombination, and repair].	1.9124e-67
NZ_AP022603.1\|WP_085093691.1\|261397_262303_+\|bifunctional-DNA-formamidopyrimidine-glycosylase/DNA-(apurinic-or-apyrimidinic-site)-lyase	gnl\|CDD\|234899	PRK01103, PRK01103, bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase.	2.56648e-142

>NZ_AP022603.1|WP_085093697.1|263152_266737_+|chromosome-segregation-protein-SMC
MHLKSLTLKGFKSFAAPTTLRFEPGITCVVGPNGSGKSNVVDALTWVMGEQGAKALRGGKMQDVIFAGTSNRAPLGRAEVTLTIDNSDNALPIEYSEVSITRRMFRDGAGEYEINGTSCRLMDVQELLSDSGIGREMHVIVGQGRLSQILESRPEDRRAFIEEAAGVLKHRKRKEKAVRKLDAMAANLARLTDLTTELRRQLKPLGRQAEVARRAATIQADLRDARLRLAADDLVARQSEFAGVGDTEAALRREHEEAAERLAVAAEELAAHESAVASLSQRADAAQQAWFRLSALAERVGATVRIAAERTQLLEAEPVAHTGADPDALEAEADEVAAHEQQLLAELDEARERAEFARAELAQAESVAAEAERAHLAAVRAEADRREGLARLTGQVETMRARVESIDERVERLSEGIEAAAARAQQAQAEFETAQGRVGELDEGEAGLDEQYERTVTALRLAEERVTELQAAERAAERQVASLHARIDALAVGLDRKDGAAWLTEHLGGGGIFGTLAGLIKVAAGHETALAAVLGSAADALAADGTVTAGSAVAALKAADGGRAALVLGDWPVTEPEDLPALPAGARWALDLVEAPARLRGALTAMLARVAVVDDIEAALTLIEAHPQLRAVTGEGDLVGLGWVSGGSDRKPSTLEITSAIERARTELAAAETQVGELAAALSGAQAEQTDRRDGAEQALAALNESDAAISQIYEQLGRLGQEARKAEEDWQSQIRRRDELESGRAQTVAELTELETRLYNAEEVPAELPDEPDDRQYLAMAADAARSAEVEARLAVRTAEERTNAVRGRADSLRRAAAAEREARLRAERARVARRHAAAVAAAVAESGRQVAGRLAGVVAVAAQRRDAFTAQRHERAAGLTAARAEVDTLNARIAALTDSLHRDEVAKAQAALRLEQLEQTILDQFGLAPADLVAEYGPDIALPPTELELAEYEQARERGEQVTAPAPMPFDRPTQERRAKRAEKELAELGRVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLDVVEQVDARILEVFTEAYADVEREFAQVFSALFPGGEGRLLLTDPSDMLTTGVEVEARPPGKKVKRLSLLSGGEKSLTAVAMLVAIFRARPSPFYVMDEVEAALDDVNLRRLIGLFEQLREKSQLIVITHQKPTMEIADALYGVTMQGDGITQVISQRMRGQELVSS
>NZ_AP022603.1|WP_085093695.1|262809_263088_+|acylphosphatase
MSEQVRLTAWVHGRVQGVGFRWWTRSRALELGLTGYAKNQPDGRVLVVAQGPRQACEGLLEHLGGGRTPGHVDTVVADWAAAGEPISGFVER
>NZ_AP022603.1|WP_085093693.1|262392_262806_+|OsmC-family-protein
MTELWVQRTGTRRYTGRSSRGAEVLVGSVDVEGVFTPGELLKIALAACAGMSADQPLARRLGDDYDARIEVSGDADRDNEVYPALAETLRIDLTGLTEAEAARVHTVVARAIDSVCTVGRTLKAGTEVTFEIADGRG
>NZ_AP022603.1|WP_085093691.1|261397_262303_+|bifunctional-DNA-formamidopyrimidine-glycosylase/DNA-(apurinic-or-apyrimidinic-site)-lyase
MPELPEVEVVRRGLAGHVVGRTITTVRVHHPRAVRRHPGGAADLIGRLRGARITGTGRRGKYLWLLLDDGESGALVVHLGMSGQMLLGGVPRAEHVRISALLDDGTALSFVDQRTFGGWQVAELVEVGGVEVPQPVAHLATDPLDPAFDRDAVVKVLRGKHSEIKRQLLDQTVVSGIGNIYADEALWRARVNGARLADGLSRPKLAAVLDAAAAVMTDALSQGGTSFDSLYVNVNGESGYFDRSLNAYGREGQGCRRCGAIIRREKFMNRSSYYCPSCQPRPRRAPRARSGTRHTGGGVPG
>NZ_AP022603.1|WP_085093689.1|260693_261398_+|ribonuclease-III
MLEDRTPLLAALGVELPEDLLTLALTHRSYAYENGGLPTNERLEFLGDAVLGLTITDELYHRHPDRTEGDLAKLRASVVNTQALAEVARGLTDGGLGAFLLLGRGELSSGGTDKSSILADGVESLLGAVYLAHGIATARVVILRIFAELLDTAPTLGAGLDWKSSLQELTVGRGLGPPSYLVSSTGPDHDKEFTATVVVADADYGEGTGRTKKEAELKAAAAAWTALEGNPAGD
>NZ_AP022603.1|WP_085093890.1|260161_260701_+|DUF177-domain-containing-protein
MRFDVSRLGRRPGALITRAETVSSPSRIGLDLIAVPEGAPMRLDLRLESVSEGVLVTGTVSAPIAGECSRCLTPFDDDVEISVTELFAYPDSATAATAEADEVGHLVDDTVDLEQCVVDAVGLALPFVPLCRPDCPGLCPHCGIALATAEPDHHHEILDPRWAKLADLDVTDEPRGGNA
>NZ_AP022603.1|WP_085093687.1|259363_260101_+|DivIVA-domain-containing-protein
MYRVFEALDELGAIVEEARGVPMTAGCVVPRGDVLELLDDIKDAIPGELDDAQDVLDARDGMLREAKAHADQMVGSATTESESMVNHARAEADRMLADAKAQADRMVAEAHAHCDRSVSEAHEEANRLVTTAKRDHESIMARAKAEADRLVESGNISYEKAVQEGIKEQQRLVSQTEVVATATAEATRLVDSAHAEADRLRGECDIYVDSKLAEFEDYLNGTLRSVGRGRHQLRTAAGTHDYVQR
>NZ_AP022603.1|WP_085093685.1|258799_259276_+|pantetheine-phosphate-adenylyltransferase
MSGAVCPGSFDPVTLGHVDVFERAAAQFDELVIAVLVNPSKKGMFTAAERMEMITEATAHLPNVRVESGSGLVVDFVKAHGLTAIVKGLRTGTDFEYELQMAQMNRHVAGVDTFFVATSAEFSFVSSSLAKEVASLGGDVSALLPEAVNRRLAAKLRN
>NZ_AP022603.1|WP_085093683.1|257395_258466_-|helix-turn-helix-transcriptional-regulator
MVTFDEFSRIAARIHGAVLAPQDWPSVMVDIQLLFDGGTAGLVVSDGASRVPRCTCMADDARTAYQDYYHPIDYVLADVEAGPVGLMVPGSGLIARAAGSEFDVDWMRPHRFTRGFFVRLTAGGDNVTFLVAGDGSRFETAARAAVFAALIPHVQQALHIEQRLHGRVLNAEDAERAADSIQRGLVLLDRGGAVIHANAAAEAILEHSDGLSRRGGRLRIEETSGRTRLQAAISAAATPGGSTDPAAQWVLCNRPSGKRPYLLHVLPAADGAVLTVVVDLDLPVKPPADVLRRIYGLTRAESDVAVRILGGKGLAPIAEELSVSLTTVRTHLQRIFDKTGTHRQAELVRLLLTLSG
>NZ_AP022603.1|WP_085093888.1|256822_257383_+|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD
MTRIIGGAAGGRRIAVPPRGTRPTTDRVRESLFNVLAARLDFDGLAVLDLYAGSGALGLEALSRGAAGAVFVESDPRAAAVIVENIAALRVSGASVHRGTAASLLSAEAPMAMDLVFADPPYDVAAADIEALLVDLTGNGWAGAGTVVVVERPNTGPRLTWPVGWAPWKERRYGDTRLEIAERQAR
>NZ_AP022603.1|WP_085093892.1|268193_270500_-|FdhF/YdeP-family-oxidoreductase
MARQPRQGGYGPVTDRDWSQQPYRHPAAAWGAALSVGKVIARQRLPIAGPKALVQMNHPIRGYDCPGCAWPDDQDGLLLDICENGIKHVTWEMTHKRVGPWFFAAHTVTELAQWTDFELEDAGRLTDPMVYDAELDRYVPISWDAAFALIGEELRGLPTPDAATFYTSGRLSNESSYIYQLFMREFGTNNMPDCSNMCHEASGRALTASIGTGKGTTDVQDWAEADLLFLLGVNAASNAPRMLTTLAAMVRSGAQVVHVNPLVEVASTKTIVPHDFLDMALFRSSQTGSLDLQVAPGGDMALMRAIAKVVFEAADTDPTALDREFLAEHTVGLEEYRALVQATGWDELVAASGLGEAQLRQAGELYLRAGRTIVSWCLGVAQHEHAVDMIREFMNVLLLRGNIGRPGAGPAPVRGHSNVQGNRTCGINHHSPAALLDALDAHHGITAPRTPGLDTVGSIEAMHRGDVAVFIALGGNFVLAAPDTDYTAEALSRCALTVQVSTKLNRSHLVHGRKALILPCLGRTEIDIQRDGPQGQTVEDAMSMVHVSYGKKKPASEALLSEPEIIARMARATLPDSTTPWEEYVANYDRIRDDMAVVLPGFAGFNDLIKNPTGFRIPQPARERVFATASGRAQFSHAPLATAAHPPEPDMLVLQTMRSHDQWNTTIYSNNDRYRGVKNIRELIFLNPADMAARGIADGALVDIVSTSKDGSQRALRSYRAIAYDTPKGSAAGYMPEMNVLIGHSDYSAQSDQPLAKSIHIRVTPAGQ
>NZ_AP022603.1|WP_085093701.1|270595_271462_-|formate-dehydrogenase-accessory-sulfurtransferase-FdhD
MGRITARHPVTRIVVGDAERRRRADLLAVEEPLEIRVNHAQLAITMRTPGHDVELAAGFLVSEGVISRGEQLHRAMHCGGPGSGGAANTYNILEVTLASGVAAPAPELSRRFLTTSACGLCGKSSIEEIETVSRYRLAEDPAELDAAVLTTFPEQLRARQAVFDKTGGLHAAALFDADSGELLVLREDVGRHNAVDKVIGWAVLADRLPLRATVLMVSGRASFELAQKAVMAGVPMLAAVSAPSSLAVELADATGLTLVGFLRGDSMNVYTHPDRIRTDAPADHSRAS
>NZ_AP022603.1|WP_085093703.1|271669_273034_+|ammonium-transporter
MAKVLPDTAFAPFGPGGLSTGDTAWVLVSAALVLLMTPALAFFYGGLSRQKSVLNMMMMSFGSIGVVGIIYVLWGYSMSFSSTHTGGSDIGGVFDNPFSLFGLTQLTQTREIDGQQAFVAGGFGTVPAIVWVAFQLTFAVITVALISGAVAERMRFGTWLAFGGIWVTLVYFPLAHMVWGGGLLSGSENSIAAWLFGTTTAQDGTVTANVAPIDFAGGTVVHINAGMAALVLAVLLGRRTGFGRIVFRPHNIPFVMLGAALLWFGWFGFNVGSEGAANMHAGLVWINTTVATAAAMLGWLVVERIRDGHATSVGAASGIVAGLVAITPACGSLSPIGAIGLGAVAGALSSLAIALKYKLGYDDSLDVVGVHLVAGLWGTVAIGLLATDTGLFYGGGIRQLVVQLVIALAALLFTAVLTIVIAFIVKPLGWRISKEDEHTGIDETLHAETAYELS
>NZ_AP022603.1|WP_085093705.1|273067_273406_+|P-II-family-nitrogen-regulator
MKLITAIVKPFTLEDVKTGLEEAGILGMTVSEVQGYGRQKGHTEVYRGAEYAVDFVPKVRVEVVVEDAAVDKVVDIIVHAARTGKIGDGKVWVSPVDTVVRVRTGERGGDAL
>NZ_AP022603.1|WP_085093707.1|273438_275871_+|[protein-PII]-uridylyltransferase
MADEPRVPKPATDLVAAARRLGAGGEHRLDSAALRAALVDLHEVWLTGTAADLGITESSGFAIVATGGLGRGEMLPHSDLDLLLLHDQMAADTVTAVAEALWYPLWDANIRVDHSVRTVGEALTVASTDLAAAMGLLEARHIAGDPELSTLLIRNARRQWRLGIAGRFPEIVEHTQARWARSGEIAHRAEPDLKNGRGGLRDVQLLTALAAAQLADVHPGAAGASAPVGSLADSQRALLDVRTELHRLSGRGRDTLLAQHADEIGAALRIGDRFDLARALSDAGRTIAYHVDAGLRTAGNALPKRGFAALRRPIRRPLDEGVIEYNGEVMLAREARPQRDPGLVLRVAAASAVTGLPMAAATLNRLADSAPEMRAPWPASALQDLLVVLGTGSSAVSTIEALDRTGLWGRLFPEWGAVRDLPPRDVVHVWTVDRHLAETVAQAGALTTRVSRPDLLVLGALLHDIGKGRGGDHSVIGAELAAQIGTRLGLWPSDIDVLVDMVRYHLLLPDTATRRDLADPVTIAEVANTLGGDLQLLELLHALAEADGLSTGPGVWGDWKATLIGDLVRRTRLALAGEPLPRADPIAERHRALAAADDEVHVELVDGDGPGTYRVTIIAPDRRGVLSRSAGVLALNALRVHSASVSSAHGSAIDTFVVAPHFGRPPAAELLRQQLSLAMAGDVDVLELLRGRAGDGAEHRRESSTRAAVPVNPPTAPPRILWHDGPDADRWLVEVRATDVTGLLAELTAVFERAGADVEWAKVTTLGASVIDVFSIAAPAGADPALRQRLEADLYAVLPAPPPVPAAEPE
>NZ_AP022603.1|WP_085093709.1|275906_277478_+|signal-recognition-particle-protein
MFESLSDRLTGALAGLRGKGRLTDADIDATAREIRLALLEADVSLPVVREFIVRVKDRAKGAEVSGALNPAQQVVKIVNEELVGILGGQTRQLSFAKTPPTVIMLAGLQGAGKTTLAGKLAKWLKGQGNNPLLVACDLQRPGAVNQLQVVGERAGVTVFAPHPGTAPGSTEIAGAGPGDPVAVAAAGLAEAKAQHFDVVIVDTAGRLGIDDVLMAQAAAIRDAVSPDETLFVLDAMIGQDAVATAEAFGAGVGFTGVVLTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMASRILGMGDVLTLIEQAEQVFDAQQAEAAAAKIGTGELTLEDFLDQMLAIRKMGPIGNLLGMLPGAGQMKDALAAVDDSQLDRIQAIIRGMTPAERTDPKIINASRRLRIANGSGVTVTEVNQLVDRFFEARKMMSQMVGGMGIPGMGRRSATRKQAKGRKGKGKGKGRGPTPPKSPFGAGMPAGMPAGFPDLTGMPKGLDELPPGLADFDLSKLKFPPQK
>NZ_AP022603.1|WP_085093711.1|277506_278574_+|amidohydrolase-family-protein
MRLHIRGTVLPDGAPAQWWIVDGVLSAEPVAGADTVFDGGWIIPGLVDAHCHVGLGPQGGVELDEAIGQAEVERDAGVLLLRDAGSPVDTGSLDDREDLPRIIRAGRHLARPKRYIPGLPIDIEDESQLPEYVAAQARRGDGWVKLVGDWIDRGAGDLAPLWSDEVLVAAVEAAHANGARVTAHVFGEDALPGLIKAGIDCIEHGTGITEDVIELMLAHGTALVPTLINIDNFPGIAEKAGRYPAYARHMRELYASCADRIGAAHEAGVAIYAGTDAGGMIAHGRISDEVAALRRVGLSPTEALGAACWSARDWLGRTGIEHGGPADLLCFAEDPRLPGVLDHPDLVILRGRVYR
>NZ_AP022603.1|WP_085093713.1|279367_280225_-|D-alanyl-D-alanine-carboxypeptidase
MAVPPVLRIRRATVAVLLSVLLVIAGLPTASAVPTAVPPDGPARAWVLADIASGAILASKDPTGRYAPASTIKTLLAMTVLDNLRPETAVRATAAHTKVECSCVGLVPGQVYTARQLLDALLMVSGNDAANLLGDMLGGYRAAITRMTNKAASLGATSTRVMSPSGLDGPGWETVTTPRDLAIIYRAAMKYPVLIQIFQQREASFPNGKGGAKTLHAQNELLARYPGDVAGKTGFTNLAGKTYAGVAQRNGRALVVVLMKGSGDLYGQAIGLLDWGFAQASGTLG
>NZ_AP022603.1|WP_085093715.1|280312_281185_-|D-alanyl-D-alanine-carboxypeptidase
MHRVLPALLAALCLFVAPTAAVAEPGDPQPQVSTAIPDGPAASWIIADMDTGEILAGRNEYASSAPASTIKTLLAQVVVDELPLDASTVAEAADTNVECNCAGVAPGQSYTVAQLLDGLLLVSGNDAANALARMLGGADTAVAKMNAKAAQLGATATRAGSPSGIDGPGISMWSTPRDLAVIFRGAMSYPVLAGVLAQPTAVFPAKGGERVLINQDEMLHRYPGFLGGKTGYTDLARKTFVGAAARDGRRLVIAMMYGLVREGGPTYWDQAASLLDWGFAQHQGAGIGML
>NZ_AP022603.1|WP_085093717.1|281278_281698_+|nuclear-transport-factor-2-family-protein
MLSLAEISDRLEIQQLLVAYSTAIDGRDFDALDAVFTPDAYIDYRESGGIDGRYPQVKAWLAEVLPNFPAYSHMLGNFDIRIDGDSATARTICFNPMVCNAETKQLLFVGLWYEDALTRTVDGWRMTRRVEVKCFDKFL

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Crispr_ID: NZ_AP022603_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022603_3

441224-441310

Orphan

Consensus_repeat	Method
ACTTCGTCCTCACTCGTCGCCCCGACGGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022603_3

>merge|NZ_AP022603|3|441224-441310|CRISPRCasFinder
ACTTCGTCCTCACTCGTCGCCCCGACGGAACCTGAGGCGCGGGGCGACTCGCTCCGGACTTCGTCCTCACTCGTCGCCCCGACGGAA

>NZ_AP022603|3|2|441224-441310|CRISPRCasFinder
ACTTCGTCCTCACTCGTCGCCCCGACGGAA	CCTGAGGCGCGGGGCGACTCGCTCCGG
ACTTCGTCCTCACTCGTCGCCCCGACGGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022603.1\|WP_085094334.1\|440257_441127_+\|diaminopimelate-epimerase	unknown	unknown	gnl\|CDD\|234768
NZ_AP022603.1\|WP_085094336.1\|439341_440253_+\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl\|CDD\|234626
NZ_AP022603.1\|WP_085094327.1\|444443_445649_+\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238425
NZ_AP022603.1\|WP_085094325.1\|446079_448287_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173841
NZ_AP022603.1\|WP_109750450.1\|435716_436181_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085094319.1\|449911_451162_-\|NarK/NasA-family-nitrate-transporter	unknown	unknown	gnl\|CDD\|225133
NZ_AP022603.1\|WP_085094321.1\|448849_449908_-\|GTP-3',8-cyclase-MoaA	unknown	unknown	gnl\|CDD\|234672
NZ_AP022603.1\|WP_085094323.1\|448283_448853_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_AP022603.1\|WP_085094317.1\|451334_455057_+\|nitrate-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|227346
NZ_AP022603.1\|WP_085094505.1\|432615_433344_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_AP022603.1\|WP_085094314.1\|456678_457335_+\|nitrate-reductase-molybdenum-cofactor-assembly-chaperone	unknown	unknown	gnl\|CDD\|225091
NZ_AP022603.1\|WP_085094342.1\|436205_437531_-\|DUF349-domain-containing-protein	unknown	unknown	gnl\|CDD\|377186
NZ_AP022603.1\|WP_085094346.1\|433400_434963_+\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	unknown	unknown	gnl\|CDD\|237674
NZ_AP022603.1\|WP_085094340.1\|437701_438640_+\|DMT-family-transporter	unknown	unknown	unknown
NZ_AP022603.1\|WP_085094315.1\|455053_456682_+\|nitrate-reductase-subunit-beta	unknown	unknown	gnl\|CDD\|224063
NZ_AP022603.1\|WP_085094338.1\|438650_439334_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|153388
NZ_AP022603.1\|WP_085094501.1\|445666_446083_+\|OB-fold-domain-containing-protein	unknown	unknown	gnl\|CDD\|224462
NZ_AP022603.1\|WP_085094329.1\|442680_444261_-\|PE-PPE-domain-containing-protein	unknown	unknown	gnl\|CDD\|369775
NZ_AP022603.1\|WP_085094348.1\|430212_431091_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NZ_AP022603.1\|WP_085094507.1\|431087_432596_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|270408

Protein	Function_ID	Function_description	E-value
NZ_AP022603.1\|WP_085094334.1\|440257_441127_+\|diaminopimelate-epimerase	gnl\|CDD\|234768	PRK00450, dapF, diaminopimelate epimerase; Provisional.	5.47631e-90
NZ_AP022603.1\|WP_085094336.1\|439341_440253_+\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl\|CDD\|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	1.14125e-138
NZ_AP022603.1\|WP_085094327.1\|444443_445649_+\|thiolase-family-protein	gnl\|CDD\|238425	cd00829, SCP-x_thiolase, Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein.	6.7989e-93
NZ_AP022603.1\|WP_085094325.1\|446079_448287_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	6.16269e-91
NZ_AP022603.1\|WP_085094319.1\|449911_451162_-\|NarK/NasA-family-nitrate-transporter	gnl\|CDD\|225133	COG2223, NarK, Nitrate/nitrite transporter [Inorganic ion transport and metabolism].	1.27814e-81
NZ_AP022603.1\|WP_085094321.1\|448849_449908_-\|GTP-3',8-cyclase-MoaA	gnl\|CDD\|234672	PRK00164, moaA, GTP 3',8-cyclase MoaA.	1.77999e-151
NZ_AP022603.1\|WP_085094323.1\|448283_448853_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	7.90018e-10
NZ_AP022603.1\|WP_085094317.1\|451334_455057_+\|nitrate-reductase-subunit-alpha	gnl\|CDD\|227346	COG5013, NarG, Nitrate reductase alpha subunit [Energy production and conversion].	0
NZ_AP022603.1\|WP_085094505.1\|432615_433344_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	2.86491e-151
NZ_AP022603.1\|WP_085094314.1\|456678_457335_+\|nitrate-reductase-molybdenum-cofactor-assembly-chaperone	gnl\|CDD\|225091	COG2180, NarJ, Nitrate reductase delta subunit [Energy production and conversion].	1.25503e-39
NZ_AP022603.1\|WP_085094342.1\|436205_437531_-\|DUF349-domain-containing-protein	gnl\|CDD\|377186	pfam03993, DUF349, Domain of Unknown Function (DUF349). This domain is found singly or as up to five tandem repeats in a small set of bacterial proteins. There are two or three alpha-helices, and possibly a beta-strand.	1.31159e-14
NZ_AP022603.1\|WP_085094346.1\|433400_434963_+\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	gnl\|CDD\|237674	PRK14326, PRK14326, (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional.	0
NZ_AP022603.1\|WP_085094507.1\|431087_432596_-\|ABC-transporter-permease-subunit	gnl\|CDD\|270408	cd13690, PBP2_GluB, Substrate binding domain of ABC glutamate transporter; the type 2 periplasmic binding protein fold. This group includes periplasmic glutamate-binding domain GluB from Corynebacterium efficiens and its related proteins. The GluB domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	8.93001e-91
NZ_AP022603.1\|WP_085094315.1\|455053_456682_+\|nitrate-reductase-subunit-beta	gnl\|CDD\|224063	COG1140, NarY, Nitrate reductase beta subunit [Energy production and conversion].	0
NZ_AP022603.1\|WP_085094501.1\|445666_446083_+\|OB-fold-domain-containing-protein	gnl\|CDD\|224462	COG1545, COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only].	1.68708e-17
NZ_AP022603.1\|WP_085094329.1\|442680_444261_-\|PE-PPE-domain-containing-protein	gnl\|CDD\|369775	pfam08237, PE-PPE, PE-PPE domain. This domain is found C terminal to the PE (pfam00934) and PPE (pfam00823) domains. The secondary structure of this domain is predicted to be a mixture of alpha helices and beta strands.	5.66315e-54
NZ_AP022603.1\|WP_085094348.1\|430212_431091_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	2.98036e-54
NZ_AP022603.1\|WP_085094338.1\|438650_439334_+\|hypothetical-protein	gnl\|CDD\|153388	cd07951, ED_3B_N_AMMECR1, The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain. This subfamily is composed of uncharacterized proteins containing an N-terminal domain with similarity to the catalytic B subunit of class III extradiol dioxygenases and a C-terminal AMMECR1-like domain. This model represents the N-terminal domain. Class III extradiol dioxygenases use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon, however, proteins in this subfamily do not contain a potential metal binding site and may not exhibit class III extradiol dioxygenase-like activity. The AMMECR1 protein was proposed to be a regulatory factor that is potentially involved in the development of AMME contiguous gene deletion syndrome.	2.58307e-23

>NZ_AP022603.1|WP_085094334.1|440257_441127_+|diaminopimelate-epimerase
MEFVKGHGTQNDFVVLPDLPARLELSVAAVSALCDRRRGLGADGVLRVTRAGAARDAGVLTTLPEGVGDDDWFMDYRNADGSIAEMCGNGVRVFAHYLAAAGLETRREFLVGTRAGPRPVQLTEAGPVHAEVSVDMGKATRTGTGAAVVGGRRMSGVGVDVGNPHLACVDPALTARTLAALDVAAPVSFDPAQFPHGVNVEVLTAPIDGAVEMRVHERGVGETRSCGTGTVAATLAALEHLGTATGTLLVRIPGGQVQVSITDATSVLRGPSELVARGQIADDWWSAQR
>NZ_AP022603.1|WP_085094336.1|439341_440253_+|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
MRPIAVIGPTGSGKSALALDLAERLPAAEIINADAMQLYRGMDIGTAKLPVAERRGITHHQLDVLEVTETATVARYQRDAVTDVAAVTARGAVPIIVGGSMLYLQSLLDDWQFPATDPAVRARWEARLADVGVAALHRELAAVDPAAAATILATDGRRIVRALEVIELTGQPFAASAPVIGAAPRWNTLIIGLDADTAALDARLRARTETMFADGLVEEVRALLDRGLRDGVTASRALGYAQVIAELDAGGDGSAALEPTFVGTRRYVRRQRSWFRRDPRVHWLRSADPGNPDAVLRRWSDVS
>NZ_AP022603.1|WP_085094338.1|438650_439334_+|hypothetical-protein
MLSSVAIIPSTPVLVPELVGAAAGEFEPLRAAVLAAAATLPPRWLAVGVGETAVYRPERRGTFAGYGADVTAALGPGDPAAVTELPLCALITGWVRARVAPGGRAEVRCWPAGTPDADARAAGAALRAELDDDPEPVGVLIVADGLSTLTPSAPGGHLPESVADQGRLDAALAAGDAAALAGLPEAVVGRAGFAVLAGLVGPGPHPAREYYRGAPLGVGYFVGTWRP
>NZ_AP022603.1|WP_085094340.1|437701_438640_+|DMT-family-transporter
MSTSSIVAAALALCAALFIGIGNVLHQRAAHAVTTERVGNFRLFLALLRNWPWWRGSLVAAVGFSCQAAALGFGSVLLVQSLMVTSLLFALFLSAHWTHRRLGRSEWTWAILLAGSVSVIVTVGKPSPGASRASLDTWLTVAAVMVPILVACLIGARLRRGAVAAVLLGLVAGSLWGVFAVLTKGVVELLGDGPRAVLTAPELYAWAVVALGGTAWQQASFRAGALTASLPTMTIAEPMVGSILGVVVLGEVLHPGRFGYGVLGLTVVVMVIATAALARVEAAAVESEPILPADDDPRPAAPEAATRAGADG
>NZ_AP022603.1|WP_085094342.1|436205_437531_-|DUF349-domain-containing-protein
MTTPESAQHTPGPRPGPRPGPKPGPKPGQHPAVPTTPASDPRRFGRVDPDGTVWLITAAGERNIASWQAGDADAAYEHFGRRYDDLSTEVALLERRLAAGTGDARKIRATAATLADTLPEAHVLGDVDALAARLAALSEHAGEAAAAARAQRDEQRAELTVRKEALAAEAEELAANSTQWKAAGDRFRTILDEWKTITGLDRKTDDALWKRFSAARESFNRRRGTHFAELDRERATVRRAKEALCERAEALSGSTDWGPTSGAFRNLLADWKAAGRTAKDLDDALWKRFKAAQDTFFSARNAISAERDAELGANADAKETLLAEAEKIDAANPRAARAALRSLTDRWDALGRGPRERDADLERRLRAVEKRIREAGEADRGPDPEAAARAAQFIARAEQFETQAAKAEAAGRSKDAEEARANAAQWRQWAEAATEALNRRS
>NZ_AP022603.1|WP_109750450.1|435716_436181_+|hypothetical-protein
MALILIAAAVGGYFLAESFLPRWWAQQIGHRVDGSFSGGIGIGLAIGFVCTFLPIMLIQFAILWRRRWKNIPAIVCGVGAVLTALPNLLTLSVVLGGGNGAHAGERIFDVSAPAFRGASLWGAIGGVLLAAVVGYFVWGYRRRGRQLHQAAEAT
>NZ_AP022603.1|WP_085094346.1|433400_434963_+|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB
MRRFPVPRAAAYHGWVTVAPTRTYQVRTYGCQMNVHDSERLAGLLEDAGYLRAADDADADVVVFNTCAVRENADNKLYGNLSHLAPRKQADPNMQIAVGGCLAQKDRAAVLTRAPWVDVVFGTHNIGSLPALLDRARHNRVAQVEILDALEEFPSNLPAARESSYAAWVSISVGCNNTCTFCIVPSLRGKEVDRRPGDILAEVTALVEQGVLEVTLLGQNVNAYGVSFADPDTPRDRGAFAALLRACGGIDGLERVRFTSPHPAEFTDDVIEAMAATPNVCPQLHMPLQSGSDRILKEMRRSYRAEKFLGIVERVRAAMPHAALTTDLIVGFPGETEEDFQATLDVVERARFASAFTFQYSPRPGTPAAELADQVPAEVVKERYGRLIELQERISLQENQAQIGRRVELLVAAGEGRKDARTARLTGRARDGRLVHFDPGPAAADIRPGDVVDTVVTAAAPHHLIADGGIAGHRRTRAGDAHEAGQRPVTRPSVGLGMPALGRPAAPVPSPTGCESGCAQ
>NZ_AP022603.1|WP_085094505.1|432615_433344_-|amino-acid-ABC-transporter-ATP-binding-protein
MIAIRKVNKHFGQLHVLKEINLEIARGEVVVVLGPSGSGKSTLCRTINRLETIDSGTIEIDGVELPEEGKRLAQLRSDVGMVFQSFNLFAHKTILDNVTLAPIKVRGMDKAAARKHGMELLERVGVANQADKYPAQLSGGQQQRVAIARSLAMTPKAILFDEPTSALDPEMVNEVLGVMTALASEGMTMVVVTHEMGFARRAANRVVFMADGAVVEDADPETFFSNPSSDRARDFLGKILNH
>NZ_AP022603.1|WP_085094507.1|431087_432596_-|ABC-transporter-permease-subunit
MASRPLRLLALVLLAVLVPLGLTSCSDGGKKITIGTKFDQPGLAAKLPDGSMAGFDVDVARYVAEELGYSPDEIDWKEAPSPQRETLIQNGQVDYIVATYSITDARKQKVGFAGPYLVTGQGLLVRAGETDITGPQSLENNKKLCSVKGSTPAQRIKQMYPRVQVQVYDTYSACLEALNNGIMDALSTDEVILAGYAAQYPGKFKLAGEPFSVENYGIGLHREDLELREQVNAALEKMISTGAWAQAFQRNLGPAGIPTPIPPQPDRYTNVAGVADVDLLGEYGAKILRAFWVTIQLAVFSAIGALVLGTALAAMRLSPVPVLAWLGTVYINVVRNTPLTLILLFCSFGLAQTLGVTLAHTDSSSFVVDSNFRLAVLGLSVYTAAFVCETLRSGVNTIPLGQAEAARSLGLTFGQNLRLILLPQAFRAVLVPLGSVLIALIKNTTIASAIGVTEAALLMSEMIENTAMLLVVGSIFAVGFIILTLPLGLLFGRLGTRLAVLR
>NZ_AP022603.1|WP_085094348.1|430212_431091_-|amino-acid-ABC-transporter-permease
MSGSVLFDAPGPRARVRNRVISAAVLVIAVAVLAVVLLQLADAGQLAAAKWKPFLTADLWRTYVWPGVQGTLSAAALSVVLAGILGVALGVARLSPNRWLQRPAAVIVEFFRAVPVLIMMIFAYFLFALYGVFPSQQLALAGVVTGLTLYNGAVIAEIIRTGVRSLPRGQTEAASSLGLSWWQTTRMIELPQAIAAMLPVLVSQLVVVLKDTAIGYQITFMEMVRQGTVIGSQYGNYLPALSVIAVLMITANFALSALAVWIEKRMRRSKRAPEPMDPDLLDADGTPIVPGD
>NZ_AP022603.1|WP_085094329.1|442680_444261_-|PE-PPE-domain-containing-protein
MSGTARRAMVAVLTMISAALLGIASIGLGSLAWAATTALIVPGTGTPDPSVKPGYMGNAVSYYIQPTGACTPADCTPEPIKYYATFWPIPLPGWGGLDGQKWNVSVADGVGYLNRAYGSGPDAGDHTVIFGYSQGATVASIVKGQLATHGTDGHIPANTSFVFIGNPNRPSGGVFERLALLGTVPILDATFGQPTPTNTTKPNPDGTLPVNTTDIAFQYDGVADFPKYPINVLADLNALAGFWYVHGTYLDPNNGGTGQPWGYTPGEIQDIVSGCAADNSGFGCQKADASDTLYVTLPAKSLPLAQPFLDLADSTGTGFLIKPVVAALQPALQTLIETGYDRSDYSSPSPFGIVPLVNPIKLATDLVNDIPEGFNAAKTTIETGNIPDLPGSTAPAPASARVAPQTENSPLRVVSGTESGDDEGPAADSPAATRPQLGKSLAKVLKFPDPAAKLKAKKQLVNVQAAADSTAAGDNDTATDGTDQAAAPKNDRPRPVRDLIRSVKNSLNKATAASKPKPKAADAPAA
>NZ_AP022603.1|WP_085094327.1|444443_445649_+|thiolase-family-protein
MGLRGEAAIVGFHELPCVRKPTGTPEFTIEQWARLAAAAVADAGLSATDVDGLITTGVFESEIFVPSTVVEYLGIPVNFAEYVDLGGASAAAMVWRAAAAIELGVCQAVLCAIPANFLTPMHPSRPPNLGDAIFYGASSFRYGSPQAEFEIPYGYLGQNGPYAQVASMYAAAHGYDERAMAKIVADQRVNANHTPGAVFAEVPATVEDVLASPIIAAPLHMLEIVMPCMGGSAILVTNETLARRSRNRPVWIKGFGERVPYKSPIYAENPLATPMRTVAPAAFAMAGLTPADMDMVSIYDCYTITALLTLEDAGFCEPGTGMRFVTDHDLTFAGDFPMNTAGGQLGYGQPGNAGGMHHVCDATRQLMGRAGATQIADCDRAFVSGNGGVLSEQEALVLEGD
>NZ_AP022603.1|WP_085094501.1|445666_446083_+|OB-fold-domain-containing-protein
MARPVPLPTPVSQPFWDGLARGEVWIQYSPSLDRYIFYPRVLAPGTLADDLLWRRIPGTGTLVSFTVAARPVAPQFADAVPQLLAVVAFDEGPRLATELVDVDPAGLRIGMRLRPVFVARPDDGVTLLHFTAEHGHPA
>NZ_AP022603.1|WP_085094325.1|446079_448287_+|acyl-CoA-dehydrogenase
MSIALTDEQQALHAAVTGFAARHAPAGDTRASFAAIAEGSRPGFWDALVDNGFHAVAVPEEFGGAGAGPLEAACVADAAGYGLLPGPLLPTMIAAALAAAAKPGPAAEALLGDIVAGGPAAALGPQAGSLRATRDGDGWSLTGTAGPEPGLCAAARILAAATTSDGQTRWFVLAGVPVTPAAGTDLTRDVGTLHLHQHRVGADALVDGLDPDTARGITAALLAAEGAGIARWCAENVVAHLKTREQFGRPIGAFQALAHRAAGLYVDAELMAAAAWDAARAAAQSPPQLAAAAAAAAIVVTAALPDLVLDALTMFGAIGYTWDHDLHLYWRRAIALAATAGPAGRWAADLGRPDAEPRDFHIELPHVETEFRAEVAAALAHAATLGNDIPGRQSPEHANLRSGAQRDALAAAGLLAPHLPPPCGRGASAVEQLIIAEEFSRHPDVVRSSLGIAEWILPTILTFGSEAQRQRFAEPILRGSHAWCQLFSEPGAGSDLAALSTRAERVDGGWRINGQKVWTSSAQQADFGALLARTDPEARKHRGIGYFLLDMSTPGITVRPLRTAGGPAHFNEVFLDDVFIPDDMLVAGPGEGWSLALATMANERAAISGYLHDDRESVLREVLAGAPSADGIRVLGEIRAATNAISALNLRETLSRLSGHGPGTATSVAKVATGRVLRRIGTAAMEFTGRAALLDTGGDTAVEHTFQLPAELIGGGTMEIQLNIIATMILGLPRG
>NZ_AP022603.1|WP_085094323.1|448283_448853_+|TetR/AcrR-family-transcriptional-regulator
MNTAAEPEYKQARRERIIAAANAALREHDYEQIQMRDVAERADVALGTVYRYFSSKEHVYAAVLMGWAEPVFGDTAADGRPAEQRVRDTVRAIIAGFERRPGFFKVCLLLQNTTDHNAAQVMAAFADLAQERLAADFAVLGRRAALDTALMLWGIVNSMLTATLLRGYPIADAYRVTDAFVDLVAPRLG
>NZ_AP022603.1|WP_085094321.1|448849_449908_-|GTP-3',8-cyclase-MoaA
MTAIPLALGRRSPAASAPPADGALVDTHGRVHRDLRISLTDRCSLRCSYCMPEQGNQWLARTSILSVAEITAVARVAASIGISTFRLTGGEPLLRPDIVEVVAALAALRGPDGPVEVAMTTNGIALPGLLEELLAAGLRRLNISIDTLRRDRFAALTRRDRLAEVRRGIAAAARSGLRPLKLNAVAMRGINDDELADLVEFAVAHGAEMRFIEQMPLDAGHTWDRAAMVTREEILTALAARWSLTPLPGRHGAPAERWLLDDGPAAVGVIAAVTAPFCGDCDRLRLTADGQLRNCLFSTGEFDLLPALRSGAPADAAIEATLRRCVWAKLPGHAINDPAFLQPARGMNAIGG
>NZ_AP022603.1|WP_085094319.1|449911_451162_-|NarK/NasA-family-nitrate-transporter
MTGDRARTAASPADAERFAGAFPQVLLATVASTVGFWAWMAIGPLQHVYNTEMNLGEGQISLMLATPVLVGALGRIITGALTDRLGGRIMFTAILLLSAPAVLLVALAGELNSFPLLILAGFCLGIAGTIFAVGIPFSGAWYPPSRRGFATGVFGMGMIGTGVSAFATPRLADRVGYLPTHLIIAGTLVAMAVLVWVFMRDSPGWAPSRDKLVPKVVGALKLPVTWEMSFLYSIVFGGFVAFSTFLPKYLTTIYPDQVDAIGAGTRTALFVAAAVIARPIGGVLADRFGPKIITLVSLGGIVSLGYVVGQEPPEGIVTGAAFIVMAAMMGLGMGAVFAWVGPSTPKDKVGAVSGVVAAAGGLGGYFPPLVMGAAYHPASNSYWIGLWLLVLLGTFALIVAGMLKDVGQRPAPDARL
>NZ_AP022603.1|WP_085094317.1|451334_455057_+|nitrate-reductase-subunit-alpha
MTRGNGAEVGPATDGPLADALLSMGRFLRPGTVSEDLRTVYLEGGRAGDAFYRDRWSHDKVVRSTHGVNCTGSCSWKVYVKDGIITWETQQTDYPSVGPDSPEYEPRGCPRGAAFSWYTYSPTRVRYPYIRDVLARLWREAKAQHPDPVDAWASIVTDPDKARAYKRARGKGGLIRTSWDEALEIAAAAHVHTVATYGPDRIAGFSPIPAMSMVSHGAGARFLNLLGGTMLSFYDWYADLPVASPQVFGDQTDVPESADWWNAGYLIMWGSNVPVTRTPDAHFMAEARYRGQKVVTVSPDYTDNTKFADEWVAPHPGTDAAVALAMGHVILREHFVQQRTEAFEDYQRRFTDAPFLITLEPHGDTLVPGKFLTAADLDGPASRQGNAEFKPVLLDADGTPVVPNGSLGHRFSAEDEGRWNLDLGQVSPPLSIADLPDWSGQAAEIALPRFDLDPAPGQEHAGGSGTVRRGVPVATVAGRTVTTVFDLMLAQYGVGRDGLPGQWPTGYDDDSTPGTPAWQQQHTSVPAAQVTRIAREFADNARRSGGRSMILMGAGANHWFHSDTIYRTFLALTTLTGCQGRNGGGWAHYVGQEKVRPITGYQQYAAAADWNRPPRFNIGTAFWYIATDQWRYDGLPADALASPLSRDMFAGRTTADCLVESVKRGWMPSYPTFNRNPLQLCEEADALGKDPAQHVVDSLTDGSLRYAVEDPDAPENFPRIALIWRANILGSSGKGNEYFLKHLLGADSAVRAPQTPPESRPTDMVWRDEAPEGKLDLLLTADFRMTSTTLFSDLVMPAATWYEKHDLSSTDMHPFVHSFNPAINPPWQTKTDYEMFGLLAERFSRYAAGHLGVRRDLVATPLQHDTPDVLATPHGRVVDAPLKPGVTMPKLTVVERDYPMLGERWKTLGPLVGTLGLVTKGIKYSYEPELQRLAGLNGTVDSGPYAGSVRLDTDRRVCEVILALSGTTNGRVAVHGFRELERHTGQQLAFLAADHAGEHITFTDVSIQPRSVITSPEWSGSEHGGRRYTAFAVNVEHLKPWHTLTGRQHFFLDHDWMSELGENLPIYRPPLDMHRLFGDEIPGAATATEVSVRYLTPHSKWSIHSEYQDNLFMLSLSRGGPVIWMSPADAAKIGVRDNEWIEAVNRNGVVVARANVSHRMPEGTVYMYHATDRTVDVPIAEASGLRGGIHNSLTRILLKPSHLIGGYAQLAWAFNYLGPTGNQRDEVTTIRRRSQEVRYR
>NZ_AP022603.1|WP_085094315.1|455053_456682_+|nitrate-reductase-subunit-beta
MKVMAQMAMVMNLDKCIGCHTCSVTCKQAWTNRTGVEYVWFNNVETRPGVGFPRGYQDQDRWQGGWVRTRRGRLKLRSGGRLAKLVRIFSNPKLPEMSDYYEPWTYDYDMLINSPAGPHTPVARPKSLITGQDMKINWSANWDDDLGGSLETMHEDPILAKMSERVEAEFSKAFMFYLPRICEHCLNPACVASCPSGAMYKRAEDGIVLVDQDACRGWRMCVSGCPYKKVYFNHKTGKAEKCTMCYPRIEVGLPTVCSETCVGRLRYLGLVLYDVDRVAAAASVENEHDLLDAQREVLLDPHDAAVIEAAGRDGIPADWIAAAQASPIWKLIQEYRVALPLHPEYRTMPMVWYIPPLSPVVDVVSDSGNDGEDARTLFAAIDKLRIPIGYLAELFTAGDVGPVDVALRRLAAMRSYMRGVNLDDERDERIAAAVGMTGREVEEMYRLLAIAKYEDRYVIPTAHAEQAQQLEELACSLDYDGGPGMGGMLGSASGQPLPVAVENFHGLAARQRSDQPSTGQVNLLNWDGNGRPDGLFPDGGDR
>NZ_AP022603.1|WP_085094314.1|456678_457335_+|nitrate-reductase-molybdenum-cofactor-assembly-chaperone
MTVAEIPVVRMDSATRAGAHMLASLLLDYPDDAWFARLPELRRHAVALPAGVGDELTGFIDAALSTDPLARQRDYVGTFDLKRKCSMYLSYYATGDTRRRGAALVAFLEAYRAAGWEFDAAELPDYLPAVLEFSARSGSPIAGALLAAHRDGIEVLRTALEGMASPWAAVIRAVAASLPPVDAATRARVLALVNDGPPVETVGLNLPMPTFGHPGSQR

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Crispr_ID: NZ_AP022603_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022603_4

554020-554114

Orphan

Consensus_repeat	Method
CCGCGGCCTGACGCAGCCCGAGCGAGCGCAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022603_4

>merge|NZ_AP022603|4|554020-554114|CRISPRCasFinder
CCGCGGCCTGACGCAGCCCGAGCGAGCGCAGCGAGTTCGGGCGGAGGAGGGCGGCAATCGGGTACCGCGGCCTGACGGAGCCCGAGCGAGCGCAG

>NZ_AP022603|4|3|554020-554114|CRISPRCasFinder
CCGCGGCCTGACGCAGCCCGAGCGAGCGCAG	CGAGTTCGGGCGGAGGAGGGCGGCAATCGGGTA
CCGCGGCCTGACGGAGCCCGAGCGAGCGCAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022603.1\|WP_085094114.1\|559565_559784_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085094018.1\|549448_551098_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173866
NZ_AP022603.1\|WP_085094034.1\|560164_560614_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085094028.1\|556431_557079_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293792
NZ_AP022603.1\|WP_085094038.1\|561044_562280_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173841
NZ_AP022603.1\|WP_085094026.1\|555474_556365_-\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|238194
NZ_AP022603.1\|WP_163742167.1\|546325_548116_+\|protein-translocase-subunit-SecD	unknown	unknown	gnl\|CDD\|235615
NZ_AP022603.1\|WP_085094040.1\|562276_563419_-\|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NZ_AP022603.1\|WP_085094157.1\|539851_540913_+\|Holliday-junction-branch-migration-DNA-helicase-RuvB	unknown	unknown	gnl\|CDD\|234619
NZ_AP022603.1\|WP_085094036.1\|560626_561043_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|238404
NZ_AP022603.1\|WP_085094159.1\|539247_539844_+\|Holliday-junction-branch-migration-protein-RuvA	unknown	unknown	gnl\|CDD\|234645
NZ_AP022603.1\|WP_085094020.1\|551052_551634_+\|adenine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|235028
NZ_AP022603.1\|WP_085094155.1\|540919_544408_-\|thioester-reductase-domain-containing-protein	unknown	unknown	gnl\|CDD\|341287
NZ_AP022603.1\|WP_085094030.1\|557075_558335_+\|histidine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234586
NZ_AP022603.1\|WP_085094153.1\|544509_545856_-\|4-aminobutyrate--2-oxoglutarate-transaminase	unknown	unknown	gnl\|CDD\|235685
NZ_AP022603.1\|WP_085094032.1\|558339_559569_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235729
NZ_AP022603.1\|WP_109750440.1\|548204_549437_+\|protein-translocase-subunit-SecF	unknown	unknown	gnl\|CDD\|237275
NZ_AP022603.1\|WP_085094151.1\|545927_546242_+\|preprotein-translocase-subunit-YajC	unknown	unknown	gnl\|CDD\|235636
NZ_AP022603.1\|WP_085094471.1\|538693_539251_+\|crossover-junction-endodeoxyribonuclease-RuvC	unknown	unknown	gnl\|CDD\|234587
NZ_AP022603.1\|WP_085094024.1\|554427_555102_-\|DsbA-family-protein	unknown	unknown	gnl\|CDD\|224565

Protein	Function_ID	Function_description	E-value
NZ_AP022603.1\|WP_085094038.1\|561044_562280_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	5.23371e-83
NZ_AP022603.1\|WP_085094018.1\|549448_551098_+\|hypothetical-protein	gnl\|CDD\|173866	cd08501, PBP2_Lpqw, The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold. LpqW is one of key players in synthesis and transport of the unique components of the mycobacterial cell wall which is a complex structure rich in two related lipoglycans, the phosphatidylinositol mannosides (PIMs) and lipoarabinomannans (LAMs). Lpqw is a highly conserved lipoprotein that transport intermediates from a pathway for mature PIMs production into a pathway for LAMs biosynthesis, thus controlling the relative abundance of these two essential components of cell wall. LpqW is thought to have been adapted by the cell-wall biosynthesis machinery of mycobacteria and other closely related pathogens, evolving to play an important role in PIMs/LAMs biosynthesis. Most of periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the LpqW protein. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	2.11828e-65
NZ_AP022603.1\|WP_085094028.1\|556431_557079_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293792	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site.	1.65902e-39
NZ_AP022603.1\|WP_085094026.1\|555474_556365_-\|peptidylprolyl-isomerase	gnl\|CDD\|238194	cd00317, cyclophilin, cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug cyclosporin (CsA). Immunosuppression in vertebrates is believed to be the result of the cyclophilin A-cyclosporin protein drug complex binding to and inhibiting the protein-phosphatase calcineurin. PPIase is an enzyme which accelerates protein folding by catalyzing the cis-trans isomerization of the peptide bonds preceding proline residues. Cyclophilins are a diverse family in terms of function and have been implicated in protein folding processes which depend on catalytic /chaperone-like activities. This group contains human cyclophilin 40, a co-chaperone of the hsp90 chaperone system; human cyclophilin A, a chaperone in the HIV-1 infectious process and; human cyclophilin H, a component of the U4/U6 snRNP, whose isomerization or chaperoning activities may play a role in RNA splicing. .	6.71221e-44
NZ_AP022603.1\|WP_163742167.1\|546325_548116_+\|protein-translocase-subunit-SecD	gnl\|CDD\|235615	PRK05812, secD, preprotein translocase subunit SecD; Reviewed.	7.35528e-128
NZ_AP022603.1\|WP_085094040.1\|562276_563419_-\|acyl-CoA/acyl-ACP-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	8.24267e-45
NZ_AP022603.1\|WP_085094157.1\|539851_540913_+\|Holliday-junction-branch-migration-DNA-helicase-RuvB	gnl\|CDD\|234619	PRK00080, ruvB, Holliday junction branch migration DNA helicase RuvB.	0
NZ_AP022603.1\|WP_085094036.1\|560626_561043_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|238404	cd00781, ketosteroid_isomerase, ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon. Ketosteroid isomerases are important members of this class of enzymes which are the most proficient of all enzymes known and have served as a paradigm for enzymatic enolizations since its discovery in 1954. This CD includes members of this class that calalyze the isomerization of various beta,gamma-unsaturated isomers at nearly a diffusion-controlled rate. These enzymes are widely distributed in bacteria.	2.38862e-13
NZ_AP022603.1\|WP_085094159.1\|539247_539844_+\|Holliday-junction-branch-migration-protein-RuvA	gnl\|CDD\|234645	PRK00116, ruvA, Holliday junction branch migration protein RuvA.	1.84022e-76
NZ_AP022603.1\|WP_085094020.1\|551052_551634_+\|adenine-phosphoribosyltransferase	gnl\|CDD\|235028	PRK02304, PRK02304, adenine phosphoribosyltransferase; Provisional.	1.45042e-67
NZ_AP022603.1\|WP_085094155.1\|540919_544408_-\|thioester-reductase-domain-containing-protein	gnl\|CDD\|341287	cd17632, AFD_CAR-like, adenylation domain of carboxylic acid reductase (CAR). This family contains the adenylation domain of carboxylic acid reductase enzymes (CARs), and performs an equivalent function to that of the ANL superfamily of adenylating enzymes. It takes a carboxylic acid substrate and ATP, and produces an AMP-acyl phosphoester intermediate, releasing pyrophosphate. Kinetic analysis using various substrates shows that this enzyme has a broad but similar substrate specificity, preferring electron-rich acids. This suggests that attack by the carboxylate on the alpha-phosphate of adenosine triphosphate (ATP) is the step that determines the substrate specificity and reaction kinetics. CAR is an important enzyme for use as a biocatalyst providing regiospecific route to aldehydes from their respective carboxylic acids.	0
NZ_AP022603.1\|WP_085094030.1\|557075_558335_+\|histidine--tRNA-ligase	gnl\|CDD\|234586	PRK00037, hisS, histidyl-tRNA synthetase; Reviewed.	0
NZ_AP022603.1\|WP_085094153.1\|544509_545856_-\|4-aminobutyrate--2-oxoglutarate-transaminase	gnl\|CDD\|235685	PRK06058, PRK06058, 4-aminobutyrate--2-oxoglutarate transaminase.	0
NZ_AP022603.1\|WP_085094032.1\|558339_559569_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|235729	PRK06185, PRK06185, FAD-dependent oxidoreductase.	0
NZ_AP022603.1\|WP_109750440.1\|548204_549437_+\|protein-translocase-subunit-SecF	gnl\|CDD\|237275	PRK13022, secF, protein translocase subunit SecF.	1.17115e-113
NZ_AP022603.1\|WP_085094151.1\|545927_546242_+\|preprotein-translocase-subunit-YajC	gnl\|CDD\|235636	PRK05886, yajC, preprotein translocase subunit YajC; Validated.	1.33416e-52
NZ_AP022603.1\|WP_085094471.1\|538693_539251_+\|crossover-junction-endodeoxyribonuclease-RuvC	gnl\|CDD\|234587	PRK00039, ruvC, Holliday junction resolvase; Reviewed.	6.61089e-77
NZ_AP022603.1\|WP_085094024.1\|554427_555102_-\|DsbA-family-protein	gnl\|CDD\|224565	COG1651, DsbG, Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones].	2.62185e-15

>NZ_AP022603.1|WP_085094020.1|551052_551634_+|adenine-phosphoribosyltransferase
MGRGLEHGPLAAVQVSARTLGAARALIGELTREVDDFPEPGVQFKDLTPVLADRRGLAAVTAALAEVAADADLIAGIDARGFLLGAAVATRLDVGMLAVRKGGKLPPPVLRQEYLLEYGSAVLEIPAAGIELAGRRVWIIDDVLATGGTVAAAGALLTEAGAAVAGAGVVLELAALDGRARVAPLPVTSLSVA
>NZ_AP022603.1|WP_085094018.1|549448_551098_+|hypothetical-protein
MTARATVRRLAAATLAVALAGATVSGCSSTADDVDYAVGGVLDTYNTNTVDGAASAGPQAFARVLTGFSYHGPDGQVVADHDFGTVSVAGRAPLVLDYQISDNAVYSDGIPVTCDDMLLTWAAQSGRFPQFGAASRAGYTDIAGLECQAGAKKARVTFINDRNFVDHLQLFGATSMMPAHVLSDRLGYGVTEAIQAVDPVRIAEIAEAWNTTWALSPGVDTAGFPSSGPYRIDSVRDDGAVLLVANERWWGSKPITARVTVWPRSIEIQDRLDDRAVDVVDVPAGSSGTLSVPDDFDRVEKPSAGIQQLFFAPVGVASVIPARRAIALCTPREEIARNAGVPLSNARLNPAADDAFSPVENVPESGGPFVNGDPAAARASLGGKPLNVRIGYRAPNARLAAVVGAIARACQPAGILVEDAAGPDVGPSSLQSGAIDVLVAGTGGASGSGSTGSSAMDAYQFHSANGNNLPRYINPAVDGIVSALAVTTDPKEQTRLLRDGDVALWEDMPTLPLYRQQRLLLTSKKMHAVTSNVTKWGAGWNMDRWQRSK
>NZ_AP022603.1|WP_109750440.1|548204_549437_+|protein-translocase-subunit-SecF
MTKAKASDEAPPVSVGAVEQTESTEPAESAPKHGFLNRLYTGTGGFDVIGKRKLWYAVSGIILAIAVLSMVLRGFTFGIDFEGGTKVSIPAGDPAISTTQVEEVFSQALGTAPESVVLVGSGESATVQVRSETLTGEQTDELTAALVEAFHPKGPDGQPGPEAISSSDVSPTWGGQITNKALIALVVFVLIVSIYIAVRYERYMAISALATMFFDLVVTAGVYSLVGFEVTPATVIGLLTILGFSLYDTVIVFDKVEENTEGFEHTTRRTYAEQANLAVNQTFMRSINTSVISALPIIALMIIAVWLLGVGTLQDLALVQLVGVVVGTYSSIYFATPLLVSMRERTELVGNHTRRVLKKRARAAGTDRAEESGGDELVEAAAAKTPAKAAAAGGTGRPSRPTGKRKSPRN
>NZ_AP022603.1|WP_163742167.1|546325_548116_+|protein-translocase-subunit-SecD
MATANTTVHPYRWLALFLVLLIGVFALVFATGDRKAEPKLGIDLQGGTRVTLTARTPDGSTPTREALQQAQQIISARVDGIGVSGSEVVIDGDNLVITVPGADGSAARNLGQTARLYVRPVVKSWPAEALAAAAGQQGGAPGVPGAPAVPGAPEMPGAPAVPGAPEVPGAPAPGAPAPGPAPAQPRPYPLDPATPTPAPEPAPAPAPAVQVPEAPGDTQGIPRDRKALAERIKFEKELRQSTNQNVLVYAGVPYTAMRCDKEDVLAGNDDPELPLVACSQDGQTVYLLDKSIISGEEIADASSGLDQQRGEYVVNVTFKGKAVDTWADFTAANVGTQTAFVLDSQVVSAPQIRSAIPGGNTQITGSFNAGTAKELANVLKYGSLPLSFESSQAETVSATLGLTSLRAGLIAGAVGLIAVLLYSLFFYRVLGLLVALSLVAAGAMIYAILVLLGRQIGYTLDLAGIAGLIIGIGMTADSFVVFFERIKDEIREGRSFRSAVPRGWTRARKTIVSGNAVTFIAAAVLYVLAIGQVKGFAFTLGLTTILDLVVVFLVTWPLVYLASKSTFMAKPICNGLGAVQQVARERRSAAATTGRR
>NZ_AP022603.1|WP_085094151.1|545927_546242_+|preprotein-translocase-subunit-YajC
MGELTVFLPLLIVMGAFMFFASRRQRKAMQATIDLHESLRVGDRVHTTAGLEATIVGITDDSVELMIAPGVVTTWMKLAIRDKIEPEIAEAAEIELADGDGTRD
>NZ_AP022603.1|WP_085094153.1|544509_545856_-|4-aminobutyrate--2-oxoglutarate-transaminase
MSAVEQSRRLATAIPGPRSLELAVRRSAAVARGVSSVLPVYARRAGGGIVEDVDGNRLIDLGSGIAVTTVGNAAPRVSAAVAAAAAEFTHTCFMVTPYRGYVEVCEQLNRLTPGRGPKRSALFNSGAEAVENAVKIARAYTGRQAVAAFDHAYHGRTNLTMALTSKAMPYKSGFGPFAPEVYRAPMSYPYRDALSDPELAGNGALAAERAIAMLDKQIGAANLAAVIIEPIQGEGGFIVPAPGFLPTLLAWCRDRGVVFIADEVQTGFARTGAMFACEDEGIEPDLIATAKGIADGLPLAAVTGRAEIMDAPHAAGLGGTYGGNPVACAAALATIETLELDGLVDRARQIGALTMDRLGRLAAEDDRIGELRGRGAMIAVELVRPGGAEPDAELTRRVAAGAHAAGVIVLTCGTFGNVLRLLPPLTISDALLTEGLDVLAEVLAALPR
>NZ_AP022603.1|WP_085094155.1|540919_544408_-|thioester-reductase-domain-containing-protein
MTETTQDQRLRDRIARLYATDPQFAAAAPDPAVAPDPALGLAAVVRAVLTGYADRPALGERAVEHRTDPATGRRTAAPLPRFDTLSYGELWHRVSAVSAALADTVAAGDRIAILGFTSTDYTTVDIATTQLAAVTVPLQTSSSAADLTPIVAETEPVLLAASVAELPHAVELIGAGPAPARLLVFDLHDGDDDHRDALAQARTALAGTDVTVQTFAEAIAAGAGIAPPERAGDGADPLAMLIYTSGSTGAPKGAMYPASRVAAMWQAGGWQWDDLQAGAPAIVPCFLPMSHVMGRGVLYSALAAGGTAYFTARADLSTLLDDLAMIQPTQLNLVPRIWDMLYGEYRAERERAGELSPAEEDALIARVRARLLGDRAVLAMTGSAPISGELRDWAQRFLDLPLVEGFGSTEAGTVMVDGVLQRPPVTDYKLIDVPELGYLSTDRPHPRGELLLRSEQMFPGYYRRPELTAEMFDEDGYYRTGDIFADLGEDRLHYVDRRNNVLKLSQGEFVAVSKLEAAYLGSPLVRQIYLYANSARPYLLAVVVPTAAALAEPDEARRKALIAESLAQVAATAGLQSYEIPRDFLIETEPFSQANGLLTGIRKLAWPKLRARYGEALERRYTELAEGQAAELARLRATGADVPVQQTVQQAAAALLGAGAAEAAPDAHFTDLGGDSLSALTFGNLLRDIFGVDVPVGVIVSPATDLAGIAAHIEAARAGHTRPSFAGIHGRDATEVHAADLTLDKFLPAETLAAAPGLPGPAAEVRTVLLTGSTGFLGRYLLLDWLQRLAPVGGTVIALVRARDDETARARLDATFDTGDPALTAHYRRLAEAHLRVIAGDKGEENLGLDAAAWQQLATDVDLIVDPAALVNHLLPYSELFAPNALGTAELLRIALTSRIKPYLYVSTIAVGDGIAPGDFVEDADIRLASPTRAVNDSYANGYGNSKWAGEVLLREANDLCGLPVAVFRSDMILADTSYAGQLNLPDMFTRMMLSLVATGIAPGSFHELDAHGRRQPSHYDGLPVEFIAEAIDTLGTAVGPGQFRTYHVMNPHDDGLGMDEFVDWLIAAGHPIRRIDDYAEWLERFETALRALPDRQRQASLLPLLHNYAKPTPPLHGAPAPTAVFRAAVIAAGIGVDGDIPHITPAVITKYISDLTLLGLL
>NZ_AP022603.1|WP_085094157.1|539851_540913_+|Holliday-junction-branch-migration-DNA-helicase-RuvB
MSRFDEDDDPDQRDVSAALTVGEGDIDASLRPRSLDEFIGQPRVREQLQLVIEGAKNRGGTPDHILLSGPPGLGKTSLAMIIAAELGSALRLTSGPALERAGDLAAMLSNLVEGDVLFIDEIHRIARPAEEMLYLAMEDFRVDVVVGKGPGATSIPLEVAPFTLVGATTRSGALTGPLRDRFGFTAHMDFYEPEELERVLRRSAGILGIELGPEAAAEIARRSRGTPRIANRLLRRVRDYAEVRADCVVTRAVAQAALLVYDVDELGLDRLDRAVLSALIRSFGGGPVGVSTLAVAVGEEATTVEEVCEPFLVRAGMIARTPRGRVATAAAWEQLGLTPPPRAAGLGQAGLFE
>NZ_AP022603.1|WP_085094159.1|539247_539844_+|Holliday-junction-branch-migration-protein-RuvA
MIASVRGEVIDIALGHVVVEAGGVGYTVMATPSTLATLRRGTEARLVTAMIVREDSQTLYGFADADARDVFTTLLSVSGVGPKIAMATLAVYDAPTLRQALADGDIAALTRVPGIGKRGAERMVLELRDKIGASPGAAGAAPVAAGAAVRGPVVEALVGLGFSAKQAEEACDKVLAADPETGTSTALRAALNLLGKTR
>NZ_AP022603.1|WP_085094471.1|538693_539251_+|crossover-junction-endodeoxyribonuclease-RuvC
MRVMGVDPGLTRCGLSVVEGGSGRQVSALDVDVVRTPSGDPLARRLLAISDTVEHWMDTHRPDVVAIERVFANANANTAMGTAQAGGVIALQAARRGIDVHFHTPSEVKAAVTGNGRADKAQVTTMITKILALQQKPTPADAADALALAICHCWRAPMIARMAQAEAKAAQIKRDYAARLKAARA
>NZ_AP022603.1|WP_085094024.1|554427_555102_-|DsbA-family-protein
MVVLVAVVVGYLLLRDPSGASGGSATMAHSIRVASPEVITKAGSHEPKVVLSLYEDFLCPHCGSLEDALGPTIDRLIDTGAVAVDYHPVAILDSMADQYSSRAGNAAFCVAQADTSPGKDVFREFRASLFEHQPVELSGEAPTDLQLSAQARLAGAPADVDDCIMDGSYLTVVRGTAAEAGIDGTPTMRLNGTDVDLHGTDGGFLSPQQLIDQVEAVVGDVPGL
>NZ_AP022603.1|WP_085094026.1|555474_556365_-|peptidylprolyl-isomerase
MSTNEQRRAAAKRKLERQLERREIKAKRQRTIALIAGGTAVVVAVAAVVTFLVLRQSDDSADVEASPASPVSTSTDDGPTVAPVSDGKLPPFTPSAGLGGNCQYPAAAKAAKENKPPRTGKVPTDPATVSASMATNQGNIGLILDNAKSPCTVNSFVSLAQQGYFNQTPCHRLTTAGSLSVLQCGDPTGAGTGGPGYEFANEYPTDQYPVGAPESQSPVLYPRGTLAMANAGPGTNGSQFFLVYQDSQLPPQYTVFGTIDETGLATLDKIAEAGVQGGGSDGKPAKTVTVTSIMLD
>NZ_AP022603.1|WP_085094028.1|556431_557079_+|MBL-fold-metallo-hydrolase
MLISGFATGLFDTNCYLLAAATNGPALVVDPGEDTVGTLEYYFAANDWTPAAVLLTHGHHGHSAAAYDLCAGWDIPVYLHRADRPLLAAGEFGEPDRVVEIDDGQLLRPAGIEVAVDLIGGHTPGSVAYRVRGGDDSGPVSVVFSGDTLLRRAVGHDCDAPGAESGPADLAELVAAIGAKLMVLHDDTVVLPGHGGATSIGAERRANPHLKDLTA
>NZ_AP022603.1|WP_085094030.1|557075_558335_+|histidine--tRNA-ligase
MSQTFKAPKGIPDYLPPDSAAFVAVRDGLLDTARRAGYGDVELPIFEETALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVMRAVIEHGLDRGALPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEVIAIADAGFRSLGLTGFRLELTSLGDDSCRPAYRELLQNFLFGLPLDEPTRARAQLNPLRVLDDKRPEVRELTADAPVLLDHLSAAAQTHFDTVRAHLDALGVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMGQLGGQDLSGIGFGLGVDRTLLALRAEGVDPAPAARVEVFGVPLGAAAKLELARLAALLRAAGVRVDLAYGDRGMKGAMRAADRSGAAITLVAGDRDIEAGTVGLKLMATGEQIDVPIGDVVAEVLARR
>NZ_AP022603.1|WP_085094032.1|558339_559569_-|FAD-dependent-oxidoreductase
MTDPGRTGCAVVGGGPAGMMLGLILARCGVEVTVLEKHADFLRDFRGDTVHPSTLTLLDELGLFERFDAIPHSRLDRVELPVGGQLVTTVDFGRLRQPHPYVAMVPQWDFLNLLAAAGAEEPNFTLRLSTAVTGLLRDDAGRIVGVRHTGPDGDGELRAELTVAADGRSSILRAAAGLVPTQWPVPFDVLWFRLPRDAAGDYSLLPRTMPGRAIIMIPRVGYFQIAYLIPKGSADGLRARGLDEFKRELAVLAPECSTDGLTDWADVHLLNVELNRLPRWHRDGLLCIGDAAHAMSPAGGVGVNVAIQDAVAAARLLYRPLREHRVTDADLAAVQRRRTPATVATQLFQRVLHRVLLAPVLSGFDVSKPGPVITVGAALLRRVPALSGLPARLIGTGLRAERLPDPARR
>NZ_AP022603.1|WP_085094114.1|559565_559784_-|hypothetical-protein
MLDRKLNLFSYSGGAITALDQVSFERRGQLRSTAAKLVAITPGGRKVLIRGYRLDGGIGRADDLLNAIARGQ
>NZ_AP022603.1|WP_085094034.1|560164_560614_+|hypothetical-protein
MTNMGKATRKAVAVLATAAASLSFGAAVAAADPAPAGEHQITYTLNGGDAQYTLYYLATQPPSKAAYDADPYQFLKKETINLAGAPWVFETTMTDPSWAILTVSSTTHGGRAAPNPHCEIAVDGNSAVQQDAPYNLSCQLKDWMAPAAP
>NZ_AP022603.1|WP_085094036.1|560626_561043_-|nuclear-transport-factor-2-family-protein
MTETTITTAAEASQASWAAVQSGDREAWLALMADDVVIEDPIGPAPTNADGRGVRGKAAVAEFYDTIVSKSNTKITCEETFPSSSPAEIAHILVLRSEFEGGHRSAVRGVFTYRVNDAGKITNLRGYWNLQVMEFSQA
>NZ_AP022603.1|WP_085094038.1|561044_562280_-|acyl-CoA-dehydrogenase-family-protein
MTETVEQFAARAARWLAENMPRIDPADPPYTVRAEQASWDRAKELQRTLHAGGFAGICFPREYGGLGLDFAYQRAFDAACRGYEMPLILNVPTFAICAATLLDMGTEEQKRDRIGAAIRGEEILCQLLSEPSGGSDLAGVITRAERTADGWLINGAKTWSTSAFAADYGLMLARTDPAVPKHQGLTMFLVPLAAPGITMRRITEVNGNEEFCEEFFDGLQVGDDAVVGAVNQGWEVASRQLFHERRAVGGGSEFSSGRGPENLQEAPTDYPALAEATGQGDDARVQDLAGRALVRRVVKEQLIEHVGSAIAAGTLPPTAGTLIRLFHAETTELEVDTALAIAGTAAVIAEAGDNADLLGLGIRYLSRQTGSLGGGSSEMARNVIGERILDFPREYAADRGVPFNQVKRGRA
>NZ_AP022603.1|WP_085094040.1|562276_563419_-|acyl-CoA/acyl-ACP-dehydrogenase
MTTDPELALFASTAAAFLEKEGSLTRVRELHAAGESFDPQSWRRAAELGWTSLLVPESLGGGSVSGDGVADLALIAEQIGHTVAPGPLHPVSVLLAALVEAPESHAETIEALIAGELIGSWAVYEPGRPAAPIQAATVATTATAIDGGYRIDGAKDRIEAGGQAQLLLVPAVCDGVVRQFLVRTDAPGVTVTEQDCIDLVKRYARAEFAGVKVDAAAVVGSAEQSAAIIERQRQVALLLQCAELVGILDTVLDFTYRWLGDRHSFGRPLASYQALKHRAADMKMWFEAARATTAGAVAAVSGRHPDAPRLVSVAKAYVAERAPVILQDCVQLHGGIGVTWEHDLHLFLRRTALYRAMFGSPEDHHRAVYAMSRRHQEASA

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Crispr_ID: NZ_AP022603_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022603_5

664503-664734

Orphan

Consensus_repeat	Method
CATCGAGTGAGAACTCAGGGACGTTGGTGAGA	CRT

4 spacers

The CRISPR arrays of NZ_AP022603_5

>merge|NZ_AP022603|5|664503-664734|CRT
CATCGAGTGAGAACCCTGGGACGTTGGTGAGAACTTTTGCCGGCCGCGCTCATCGAGTGGGAACTCAGGGACGTTGGTGAGACGTTTTGCCGGGGTCCGACATCGAGTGAGACTTCAGGGACGTTGGTGAGAACTTTTGCCGGCCGCGCTCATCGAGCGAGAACTCAGGGACGTTGGTGAGACGTTTTGCCGGGGCCCGACATCGAGTGAGAACTCAGGGAGCTTGGTGAGA

>NZ_AP022603|5|2|664503-664734|CRT
CATCGAGTGAGAACCCTGGGACGTTGGTGAGA	ACTTTTGCCGGCCGCGCT
CATCGAGTGGGAACTCAGGGACGTTGGTGAGA	CGTTTTGCCGGGGTCCGA
CATCGAGTGAGACTTCAGGGACGTTGGTGAGA	ACTTTTGCCGGCCGCGCT
CATCGAGCGAGAACTCAGGGACGTTGGTGAGA	CGTTTTGCCGGGGCCCGA
CATCGAGTGAGAACTCAGGGAGCTTGGTGAGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022603.1\|WP_085092403.1\|658963_660409_+\|Fe-S-cluster-assembly-protein-SufB	unknown	unknown	gnl\|CDD\|131035
NZ_AP022603.1\|WP_085092404.1\|658141_658903_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|225222
NZ_AP022603.1\|WP_085092401.1\|661583_662351_+\|Fe-S-cluster-assembly-ATPase-SufC	unknown	unknown	gnl\|CDD\|223473
NZ_AP022603.1\|WP_085092405.1\|656456_658109_-\|polyprenol-phosphomannose-dependent-alpha-1,6-mannosyltransferase-MptB	unknown	unknown	gnl\|CDD\|274589
NZ_AP022603.1\|WP_163742634.1\|654718_655435_-\|multidrug-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|272861
NZ_AP022603.1\|WP_085098537.1\|670107_670671_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_AP022603.1\|WP_085098529.1\|675810_676524_+\|NlpC/P60-family-peptidoglycan-endopeptidase-RipB	unknown	unknown	gnl\|CDD\|366353
NZ_AP022603.1\|WP_085098542.1\|667628_668456_+\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|168278
NZ_AP022603.1\|WP_085092406.1\|655509_656445_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_AP022603.1\|WP_085092398.1\|664123_664468_+\|metal-sulfur-cluster-assembly-factor	unknown	unknown	gnl\|CDD\|225062
NZ_AP022603.1\|WP_085098545.1\|667228_667591_+\|thioredoxin	unknown	unknown	gnl\|CDD\|200072
NZ_AP022603.1\|WP_085098590.1\|673659_674193_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085092399.1\|663611_664127_+\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	unknown	unknown	gnl\|CDD\|273918
NZ_AP022603.1\|WP_085098535.1\|670680_673500_-\|aconitate-hydratase	unknown	unknown	gnl\|CDD\|236445
NZ_AP022603.1\|WP_085098532.1\|674419_675796_+\|NlpC/P60-family-peptidoglycan-endopeptidase-RipA	unknown	unknown	gnl\|CDD\|366353
NZ_AP022603.1\|WP_085098550.1\|665179_665530_+\|DUF485-domain-containing-protein	unknown	unknown	gnl\|CDD\|377315
NZ_AP022603.1\|WP_085092402.1\|660408_661587_+\|Fe-S-cluster-assembly-protein-SufD	unknown	unknown	gnl\|CDD\|223791
NZ_AP022603.1\|WP_085092400.1\|662350_663604_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|131034
NZ_AP022603.1\|WP_085098548.1\|665526_667158_+\|cation-acetate-symporter	unknown	unknown	gnl\|CDD\|271374
NZ_AP022603.1\|WP_085098540.1\|668469_670101_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562

Protein	Function_ID	Function_description	E-value
NZ_AP022603.1\|WP_085092403.1\|658963_660409_+\|Fe-S-cluster-assembly-protein-SufB	gnl\|CDD\|131035	TIGR01980, UPF0051_protein_slr0074, FeS assembly protein SufB. This protein, SufB, forms a cytosolic complex SufBCD. This complex enhances the cysteine desulfurase of SufSE. The system, together with SufA, is believed to act in iron-sulfur cluster formation during oxidative stress. Note that SufC belongs to the family of ABC transporter ATP binding proteins, so this protein, encoded by an adjacent gene, has often been annotated as a transporter component. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_AP022603.1\|WP_085092404.1\|658141_658903_+\|transcriptional-regulator	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	1.00563e-65
NZ_AP022603.1\|WP_085092401.1\|661583_662351_+\|Fe-S-cluster-assembly-ATPase-SufC	gnl\|CDD\|223473	COG0396, sufC, Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones].	4.33379e-147
NZ_AP022603.1\|WP_085092405.1\|656456_658109_-\|polyprenol-phosphomannose-dependent-alpha-1,6-mannosyltransferase-MptB	gnl\|CDD\|274589	TIGR03459, crt_membr, carotene biosynthesis associated membrane protein. This model represents a family of hydrophobic and presumed membrane proteins found in the Actinobacteria. The genes encoding these proteins are syntenically associated with (found proximal to) genes of carotene biosynthesis ususally including phytoene synthase (crtB), phytoene dehydrogenase (crtI) and geranylgeranyl pyrophosphate synthase (ispA).	4.11791e-61
NZ_AP022603.1\|WP_163742634.1\|654718_655435_-\|multidrug-ABC-transporter-permease	gnl\|CDD\|272861	TIGR00025, Mtu_efflux, ABC transporter efflux protein, DrrB family. The seed members for this model are a paralogous family of Mycobacterium tuberculosis. Nearly all proteins scoring above the noise cutoff are from high-GC Gram-positive organisms. The members of this paralogous family of efflux proteins are all found in operons with ATP-binding chain partners. They are related to a putative daunorubicin resistance efflux protein of Streptomyces peucetius. This model represents a branch of a larger superfamily that also includes NodJ, a part of the NodIJ pair of nodulation-triggering signal efflux proteins. The members of this branch may all act in antibiotic resistance.	9.00812e-45
NZ_AP022603.1\|WP_085098537.1\|670107_670671_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	9.81424e-14
NZ_AP022603.1\|WP_085098529.1\|675810_676524_+\|NlpC/P60-family-peptidoglycan-endopeptidase-RipB	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	1.03876e-34
NZ_AP022603.1\|WP_085098542.1\|667628_668456_+\|enoyl-CoA-hydratase	gnl\|CDD\|168278	PRK05864, PRK05864, enoyl-CoA hydratase; Provisional.	9.00716e-177
NZ_AP022603.1\|WP_085092406.1\|655509_656445_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	2.29948e-90
NZ_AP022603.1\|WP_085092398.1\|664123_664468_+\|metal-sulfur-cluster-assembly-factor	gnl\|CDD\|225062	COG2151, PaaD, Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only].	1.3681e-32
NZ_AP022603.1\|WP_085098545.1\|667228_667591_+\|thioredoxin	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	2.41999e-40
NZ_AP022603.1\|WP_085092399.1\|663611_664127_+\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	gnl\|CDD\|273918	TIGR01994, Iron-sulfur_cluster_assembly_scaffold_protein_IscU, SUF system FeS assembly protein, NifU family. Three iron-sulfur cluster assembly systems are known so far. ISC is broadly distributed while NIF tends to be associated with nitrogenase in nitrogen-fixing bacteria. The most recently described is SUF, believed to be important to maintain the function during aerobic stress of enzymes with labile Fe-S clusters. It is fairly widely distributed. This family represents one of two different proteins proposed to act as a scaffold on which the Fe-S cluster is built and from which it is transferred. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	3.15157e-66
NZ_AP022603.1\|WP_085098535.1\|670680_673500_-\|aconitate-hydratase	gnl\|CDD\|236445	PRK09277, PRK09277, aconitate hydratase AcnA.	0
NZ_AP022603.1\|WP_085098532.1\|674419_675796_+\|NlpC/P60-family-peptidoglycan-endopeptidase-RipA	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	4.78425e-39
NZ_AP022603.1\|WP_085098550.1\|665179_665530_+\|DUF485-domain-containing-protein	gnl\|CDD\|377315	pfam04341, DUF485, Protein of unknown function, DUF485. This family includes several putative integral membrane proteins.	5.35331e-36
NZ_AP022603.1\|WP_085092402.1\|660408_661587_+\|Fe-S-cluster-assembly-protein-SufD	gnl\|CDD\|223791	COG0719, SufB, Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones].	2.23781e-89
NZ_AP022603.1\|WP_085092400.1\|662350_663604_+\|cysteine-desulfurase	gnl\|CDD\|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_AP022603.1\|WP_085098548.1\|665526_667158_+\|cation-acetate-symporter	gnl\|CDD\|271374	cd11480, SLC5sbd_u4, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	6.83553e-170
NZ_AP022603.1\|WP_085098540.1\|668469_670101_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	4.68628e-174

>NZ_AP022603.1|WP_085092398.1|664123_664468_+|metal-sulfur-cluster-assembly-factor
MTELTPEETLVADLHEAMHDVVDPELGINVVDLGLVYGLGVEDSGTGKIALIDMTLTSPACPLTDVIEDQTRTALVGPSLVSEIRINWVWNPPWGPDKITDDGREQLRALGFTV
>NZ_AP022603.1|WP_085092399.1|663611_664127_+|SUF-system-NifU-family-Fe-S-cluster-assembly-protein
MRLEQMYQEVILDHYKHPHHRGLREPFGAQVHHVNPTCGDEVTLRVALSADGDTVADVSYDGQGCSISQAATSVLADQVIGASVGDALKSVTAFGEMISSRGTVEGDEDLIGDGIAFAGVAKYPARVKCALLGWMAFKDALAQASGEKHAPAQAGGDNHALAQAGSSEEQS
>NZ_AP022603.1|WP_085092400.1|662350_663604_+|cysteine-desulfurase
MTTATGLDAGRLTAVRADFPILSRVMRGGQQLAYLDSGATSQKPLAVLDAERDFLLNHYGAVHRGAHQLMEEATDAYEDGRAAIAGFVGADADELVFTRNATESLNLLSYVLGDDRFAGAVGPGDVVVVTELEHHANLIPWQELCRRTGAELRWYGVTDDGRIDLDSLTLDERVKVVAFTQHSNVTGAIAPVAEFVARAKAVGALTVLDACQSVPHQVVDFHALDVDFAAFSGHKMLGPTGIGVLYGRRELLAVLPPFQTGGSMIETVTMERASYAPAPQRFEAGTPMTSQVVGLAAAARYLDAIGMDLVEAHEADLVRAAIAGLSEIPEVRIVGPLTDELRGSPVAFVVDGVHAHDVGQVLDDEGVAVRVGHHCVYPLHSRYGLAATVRASFAVYNTLDEVDRLIAGVRRSLEFFS
>NZ_AP022603.1|WP_085092401.1|661583_662351_+|Fe-S-cluster-assembly-ATPase-SufC
MTTLEIKDLHAAVIADDGTAIPILKGVNLTVRSGETHAVMGPNGSGKSTLSYAIAGHPKYTVTGGSITLDGADVLAMSVDERARAGLFLAMQYPVEVPGVSMSNFLRTATTAVRGEAPKLRHWVKEVKAAMAELDIDPTFGERSVNEGFSGGEKKRHEILQLSLLKPKIAILDETDSGLDVDALRIVSEGVNRYAEAEHGGVLLITHYTRILRYIQPQFVHVFVDGRIVESGGPELADQLEEHGYERFTQASAGA
>NZ_AP022603.1|WP_085092402.1|660408_661587_+|Fe-S-cluster-assembly-protein-SufD
MAQLETTPGTPVVVNKGELFSSFDVDAFEVPGGRDEIWRFTPLRRLRGLHDGTAPATGRAEVSVTAQPGVTVEQVGRDDARLGAAGAPTDRVAAQAYSSFETATVVTVARDTEVAEPIEIVVTGPGENQVGYGHLQLRVEELARAIVVVDLRGSGVYADNVEIIVGDSAGLGVIWIADWADDAVHVSSQHARIGRDAVLGHVNVTLGGDLVRTTVSVGYTGPGGDAQLLGTYFADDGQFFESRLLVDHTHPNCRSDVLYKGAVQGDPSSRRPDAHTVWIGDVLIRAEATGTDTFEVNRNLLLTDGARADSVPNLEIETGEIVGAGHASATGRFDDEQLFYLRARGIPEDQARRLVVRGFFNEIIAKIAVPAVRERLTDAIEQELAITESRTS
>NZ_AP022603.1|WP_085092403.1|658963_660409_+|Fe-S-cluster-assembly-protein-SufB
MTLTPEAGVAPEALTQEEALAALGHYDYGWSDSDAAGAAAARGLSEAVVRDISAKKNEPEWMLDVRLRALRTFDKKPMPNWGSNLDGIDFDNIKYFVRSTEKQATSWEELPEDIRNTYDRLGIPEAEKQRLVAGVAAQYESEVVYHQIREDLEALGVIFLDTDSGLREHPELFREYFGTVIPAGDNKFSALNTAVWSGGSFIYVPKGVHVDIPLQAYFRINTENMGQFERTLIIADEGSYVHYVEGCTAPIYKSDSLHSAVVEIVVKPGARVRYTTIQNWSNNVYNLVTKRARAEAGATMEWIDGNIGSKVTMKYPAVWMTGEHAKGEVLSVAFAGEGQHQDTGAKMLHLAPNTSSNIVSKSVARGGGRSSYRGLVQINKGAHGAKASVKCDALLVDTISRSDTYPYVDIREDDVTMGHEATVSKVSDNQLFYLMSRGLTEDEAMAMVVRGFVEPIAKELPMEYALELNRLIELQMEGAVG
>NZ_AP022603.1|WP_085092404.1|658141_658903_+|transcriptional-regulator
MPVRQVRVPLLDRGVELRHTDVVKFVSGVPSATPVAGDGHTRREIIRLLLESGPVTAGRISERLGLSAAGVRRHLDALIDAGEAQTVAAAAWQQAGRGRPAKRYLLTAAGRARLEHAYDDLAAAAMRALREVGGEDAVRSFARRRIDTILERVEAAADEGEEAVEQTAEEIAAAFTGAGYVTSTTPVGGPIRGVQICQHHCPVSHVAREFPELCDAEAQAMSELLGTHVQRLATIVNGDCACTTHVPLAPTGN
>NZ_AP022603.1|WP_085092405.1|656456_658109_-|polyprenol-phosphomannose-dependent-alpha-1,6-mannosyltransferase-MptB
MAPRRPSLSTSIARWHGDERTVGSPLNTAEVVALRRTRLFGSTGTILMAIGALGAGARPVIQDPTFGVRLLNLPSRLQTVSLTMTTTGAVMMALAWLLLGRFTTGPRRMSRSQLDRTLMLWILPLLIAPPMYSKDVYSYLAQSEIARNGLDPYTVGPAPGLGLGHVFTLSVPSLWRETPAPYGPLFLWIGRGISAITGENIVAGVLLHRLVVLLGVALIIWAVPRLARRCGVAEVSAMWLGAANPLLLMHLVAGIHNEAPMLGLMLAGTEFALRGIESRHRLLPRPLRAPSTEADWQRWAPLLQLLAGTVLIAMSSQIKLPSLLAVGFVAMALAHRWGGTVRAFFAASGSLTAIAVLVIVVIGKASGLGFGWLFTLGTANVVRSWMSPPTLLALGAGQGGILLGLGDHTTAVLALTRAIGVLIIAVLVTWLLLTVLRGRLHPVGGLGVALGTTVLLFPVVQPWYLLWAIIPLACWATRPGFRIAVIVTTLVVGILGPTANGDRFALFQIVDATLASAVVVALLIGLTWRRLPWRAMPAGDTDPSPAPVTA
>NZ_AP022603.1|WP_085092406.1|655509_656445_-|ABC-transporter-ATP-binding-protein
MSSAASSNPAVRLRGVSKRYGETTAVAGLDLEVAPAEVFALLGPNGAGKTTTVEMCEGFVTPDSGSVEVLGLDPLADNAALRPRIGVMLQGGGGYPAARAGEMLNLVAAYSANPLDPAWLLDTLGLTEAARTTYRRLSGGQQQRLALACAIVGRPELVFLDEPTAGMDAHARLVVWELIEGLRRDGVTVVLTTHHLNEAEELADRIVIIDRGRAVAAGTPAELTRSGAEDQLRFSAPPRLDLTLLTAALPEGYRATETSPGQYLVEGRIDPQVPATVAAWAARMDVLATGIRVQQRSLEDVFLELTGRELR
>NZ_AP022603.1|WP_163742634.1|654718_655435_-|multidrug-ABC-transporter-permease
MLAAQYGLELKLLLRNGEQLLLTMFIPITLLIGMVLMPIGDFGTDRAAVFTPAIMALAVISTAFTGQAIAVAFDRRYGALKRLGATALPVWGVIAGKALAVITTVFLQALLLGGIALALGWRPAPAGLALGAVIIALGTASFAALGLLLGGTLRAEIVLAVANLGWFIFAGFGALVLPSADGLVPPWLRLIARCTPSGALTEALTAATTVSVDWFGIAVLAIWGLIGAAGALRWFRFT
>NZ_AP022603.1|WP_085098550.1|665179_665530_+|DUF485-domain-containing-protein
MSEEVRPPSPSGEQFLAAAASPEFQDLKRRLRRFVFPMTVFFLIWYAVYVLLSTFAIDFMATPVLGNYNLGMLIGLGQFISTFVITGLYVRFANRELDPRAAKIRGELERAAGAER
>NZ_AP022603.1|WP_085098548.1|665526_667158_+|cation-acetate-symporter
MSTGYLAAETVGNPMANMAIFGLFVVVTLVVVIRASNKNATAAEFFTGGRAFSGPQNGIAIAGDYLSAASFLGIAGAIAVYGYDGFLYSIGFLVAWLVALLLVAELLRNTGKFTMADVLSFRLKQKPVRLAAATSTLTVSLFYLLAQMAGAGGLVALLMDVRSRTGQSIVIAVVGVLMIVYVLVGGMKGTTWVQIIKAVLLIAGAAVMTAMVLARFGLNLSDILGSAQSAIAASTDPVVAGRDVLAPGAQYGGSLTSKINFLSLAIALVLGTAGLPHVLMRFYTVPTAKEARRSVVWAIALIGAFYLFTLVLGYGAAAIVGPDRILAAAGGQNAAAPLLAFELGGVILLGVIAAVAFATILAVVAGLTITAAASFAHDVYASVLKSHTVSEAEQVRVSRITAVVLGLLGIGLGILANGQNIAFLVALAFAVAAAANLPTIVYSLYWRRFNTRGALWSMYGGLAATIVLIVFSPAVSGSPTAMIPGADFAWFPLANPGIVSIPLAFVLGIVGTLTAPDDEDPVLAAEMEVRSLTGIGAEPAVEH
>NZ_AP022603.1|WP_085098545.1|667228_667591_+|thioredoxin
MATQDITAAEFDNLVTGNDIVLVDFWASWCGPCRAFAPTFAKASEEHPDVVFAKVDTEAQQELAAAAQIRSIPTLMAFKQGKLVFNQAGALPGPALEDLIQKVKEFDVDAAIAASDQQDR
>NZ_AP022603.1|WP_085098542.1|667628_668456_+|enoyl-CoA-hydratase
MSVTAHSEFVLVDRPRPHVALITLNRPERMNSMAFDVMLPLREVLRQITDDNDVRAVVLTGAGAGFSSGADHKSAGAVPNVAGLTRPGFGLRTMEILDEVILGLRRLHQPVIAAVNGAAIGGGLCLALACDIRVASPDAYFRAAGINNGLTASELGLSYLLPRAIGTSRAFELMLTGRDVDAPEAERIGLVSRLVPAQDLIGECVTMGERIAGFSRPGVELTKRTLWSGLDAGSLESHMQAEGLGQLYVRLLTANFEEAVAARAQGRAPKFTDDK
>NZ_AP022603.1|WP_085098540.1|668469_670101_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MITATDLEVRAGARTLLAAEGPALRIQPGDRIGLVGRNGAGKTTTMRILAGEGEPYAGTITRTGEVGYLPQDPREGDLDVLARDRVLSARGLDTLLADLEKQQTLMAELADEAGRDKAIRRYGQLEERFSALGGYAAESEAGRICASLGLAERILAQPLRTLSGGQRRRVELARILFAASESGVAGGSTTLLLDEPTNHLDADSIGWLREFLRNHSGGLVVISHDVDLLADVVNRVWFLDAVRGEADVYNMGWHKYLDARATDEQRRRRERANAERKAGALRAQAAKMGAKATKAVAAQNMLRRAERMMAELDEERVADKVARIKFPTPAPCGKTPLMASGLTKTYGSLEVFTGVDLAIDRGSRVVVLGLNGAGKTTLLRVLAGTETPDAGQLEPGHGCRIGYFAQEHDTLDNDATVWENIRHAAPDTGEQDLRGLLGAFMFTGPQLEQPAGTLSGGEKTRLALAGLVASTANVLLLDEPTNNLDPASREQVLDALRSYTGAVVLVTHDPGAAEALEPQRVVLLPDGTEDFWSQDYRELIELA
>NZ_AP022603.1|WP_085098537.1|670107_670671_-|TetR/AcrR-family-transcriptional-regulator
MPKVSEDHLAARRRQILDGARRCFAEFGYDKATVRRLEESIGLSRGAIFHHFRDKDSLFFELAREDAERMAEVASREGLIQVMRDMLAAPEQFDWLATRLEISRKLRTDQAFHRGWAERSTELVNATSERLRQQREAGRLREDVPGEVLQTYLDLVLDGLITRLASGDDPAQLGAVLDLVERSVRQS
>NZ_AP022603.1|WP_085098535.1|670680_673500_-|aconitate-hydratase
MTSQNSFGAHDTLQVGDHSYQMYRLDAVPGTEKLPYSLKVLAENLLRTEDGANITKDHILALANWDPSAEPSVEIQFTPARVIMQDFTGVPCVVDLATMREAVAALGGDPEKVNPLAPAELVIDHSVILDVFGTPDAFERNVELEYQRNGERYQFLRWGQGAFADFKVVPPGTGIVHQVNIEHLARVVFERDGVAYPDTCVGTDSHTTMENGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFKLTGEIQPGVTATDVVLTVTDMLRRHGVVGKFVEFYGKGVAEVPLANRATLGNMSPEFGSTCAIFPIDDETINYLRLTGRSDEQLALVEAYAKAQGMWHNPDREPVFSEYLELDLSTVVPSIAGPKRPQDRILLSESKVAFRKDIHNYVEENLPAPHTQLDEAIEESFPASDPVKLSFADDGAADLRPSAANGSHGRPTKPVLVSSADRGEFYLDHGAVAVAGITSCTNTSNPSVMIGAALLAKKAVEKGLSSKPWVKTNMAPGSQVVTDYYNKAGLWPYLEKLGFYLGGYGCTTCIGNTGPLPEEISAAVNDNDLAVTAVLSGNRNFEGRISPDVKMNYLASPPLVIAYAIAGTMDFDFETEPLGTDTDGNPVFLRDIWPSATEIEDTIASSINREMFTASYADVFKGDERWRNLPTPEGNTFAWDDASTYVRKAPYFDGMGLEPEPVSDIAGARVMALLGDSVTTDHISPAGSIKRGTPAADYLEANGVDPKDFNSLGSRRGNHEVMIRGTFANIRLQNRVLDTIGLEGTQGGYTRDFTQDGGPKEFIYTACENYQKAGIPLVVLGGKEYGSGSSRDWAAKGTTLLGVKAVITESFERIHRSNLIGMGVIPLQFPAGENAKTLGLDGTETFDIVGIEELNTGKTPKTVHVTATKLDGAKVEFDAVVRIDTPGEADYYRNGGILQFVLRNMLKA
>NZ_AP022603.1|WP_085098590.1|673659_674193_+|hypothetical-protein
MHGALFDPYPPAFIPHEVDMVRVQEQVAADGVSAPAGVDRSALEQVVTAAGNDGIELKIVVIEDNPPIDTPLRDIANEVGQQHPGATVLVLSPSFAGTYSPSYDRATLEAGEDLAKTGNPVQSAENFVSQLNTPIFPWTALTVVLLAVVVLGAALARVAGVRARRRADPESACAAEG
>NZ_AP022603.1|WP_085098532.1|674419_675796_+|NlpC/P60-family-peptidoglycan-endopeptidase-RipA
MRLINGAPPLLTLALVLGTAGPAAAEPAPAPDGLAALITQVAEANQRLQDLGAQVQIEQESVNKRLVELQGARNTAAKAQLEVDASRQAVREYDGAIDDAQARFDDYAIATYMSGPSDSLLAATDPGEMLTAVSTNETINLASRQVMTDLKRARGEQVNRESTARLAKQKADQAAAGAQTSQDDAVTALTNAQATFGRQQEQINQLAAERDAAKARLDQARAALAPARPPAPGSPAPAGAPAASDWDAAPAVGDASQWDTTLPMVPSAFVSGDPIAIVNTVLAISATSAEVTAGLGRKFLQKIGILAPDTVDVPTDGTAIPRVYGRQASEYVIQRGMSQLGVPYSWGGGNAQGKSYGIDSGSNTLGFDCSGLVLYAFAGVGIELPHYSGSQYNMGRKIPSAEMRRGDVIFYGPGGSQHVTIYLGNGQMLEAPYTGSQVKVSPVRTGGMTPYVVRYIEY
>NZ_AP022603.1|WP_085098529.1|675810_676524_+|NlpC/P60-family-peptidoglycan-endopeptidase-RipB
MAVSAFRPAIGRPAQLLAVLVLALGLTVGWARPAAADPGWDPSLPAVASAGAPGDALAIANASLAVTSQATSATMDLGRKFLKSLGFGGRDAEPTGVNPGRVRGPQAIEYVIRRGGSQLGMPYSWGGGKPTGPSTGVESGANIYGFDCSGLTQYSFAGVGVLIPKYSGDQYDAGRRVPLSQAKRGDLLFWGPGGSQHVAIYLGGGQMLEASGSAGRVRVSPVRTSGIQPNAVRVIES

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Crispr_ID: NZ_AP022603_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022603_6

1115191-1115279

Orphan

Consensus_repeat	Method
CGGCTGGCGCAGGTGCTGACGTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022603_6

>merge|NZ_AP022603|6|1115191-1115279|CRISPRCasFinder
CGGCTGGCGCAGGTGCTGACGTCACAGCAGCAGCCGCCTTGGCAGCCGACCTCGCAGCAGCCTTCACGGCCGGCGCAGGTGCTGACGTC

>NZ_AP022603|6|4|1115191-1115279|CRISPRCasFinder
CGGCTGGCGCAGGTGCTGACGTC	ACAGCAGCAGCCGCCTTGGCAGCCGACCTCGCAGCAGCCTTCA
CGGCCGGCGCAGGTGCTGACGTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022603.1\|WP_109750464.1\|1109501_1109837_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224755
NZ_AP022603.1\|WP_085094785.1\|1119114_1119558_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_AP022603.1\|WP_085094783.1\|1119830_1120211_+\|phage-holin-family-protein	unknown	unknown	gnl\|CDD\|224861
NZ_AP022603.1\|WP_085094769.1\|1126486_1126933_-\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|224630
NZ_AP022603.1\|WP_085094803.1\|1104051_1105632_+\|FMN-binding-glutamate-synthase-family-protein	unknown	unknown	gnl\|CDD\|239202
NZ_AP022603.1\|WP_085094779.1\|1120785_1121055_+\|YdeI/OmpD-associated-family-protein	unknown	unknown	gnl\|CDD\|379149
NZ_AP022603.1\|WP_085094787.1\|1118342_1119020_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293792
NZ_AP022603.1\|WP_085094795.1\|1108005_1108200_-\|50S-ribosomal-protein-L35	unknown	unknown	gnl\|CDD\|234676
NZ_AP022603.1\|WP_109750465.1\|1108244_1108907_-\|translation-initiation-factor-IF-3	unknown	unknown	gnl\|CDD\|234582
NZ_AP022603.1\|WP_085094775.1\|1124305_1124899_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133380
NZ_AP022603.1\|WP_085094771.1\|1125752_1126487_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133378
NZ_AP022603.1\|WP_085094777.1\|1121118_1124097_-\|aminomethyl-transferring-glycine-dehydrogenase	unknown	unknown	gnl\|CDD\|235432
NZ_AP022603.1\|WP_163742235.1\|1109909_1113221_+\|bifunctional-lysylphosphatidylglycerol-synthetase/lysine--tRNA-ligase-LysX	unknown	unknown	gnl\|CDD\|235095
NZ_AP022603.1\|WP_085094853.1\|1113369_1114764_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223700
NZ_AP022603.1\|WP_085094781.1\|1120260_1120728_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085094773.1\|1125167_1125665_-\|bifunctional-nuclease-family-protein	unknown	unknown	gnl\|CDD\|376830
NZ_AP022603.1\|WP_109750466.1\|1105708_1106638_-\|adenylate/guanylate-cyclase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143636
NZ_AP022603.1\|WP_085094791.1\|1109129_1109483_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085094799.1\|1106758_1107511_-\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|223640
NZ_AP022603.1\|WP_085094797.1\|1107552_1107942_-\|50S-ribosomal-protein-L20	unknown	unknown	gnl\|CDD\|179959

Protein	Function_ID	Function_description	E-value
NZ_AP022603.1\|WP_109750464.1\|1109501_1109837_+\|hypothetical-protein	gnl\|CDD\|224755	COG1842, PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms].	0.001142
NZ_AP022603.1\|WP_085094785.1\|1119114_1119558_-\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	1.3301e-24
NZ_AP022603.1\|WP_085094783.1\|1119830_1120211_+\|phage-holin-family-protein	gnl\|CDD\|224861	COG1950, COG1950, Predicted membrane protein [Function unknown].	1.4825e-22
NZ_AP022603.1\|WP_085094769.1\|1126486_1126933_-\|FHA-domain-containing-protein	gnl\|CDD\|224630	COG1716, COG1716, FOG: FHA domain [Signal transduction mechanisms].	4.91985e-28
NZ_AP022603.1\|WP_085094803.1\|1104051_1105632_+\|FMN-binding-glutamate-synthase-family-protein	gnl\|CDD\|239202	cd02808, GltS_FMN, Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast and bacterial pathway for ammonia assimilation. It is a multifunctional enzyme that functions through three distinct active centers, carrying out L-glutamine hydrolysis, conversion of 2-oxoglutarate into L-glutamate, and electron uptake from an electron donor.	2.30793e-161
NZ_AP022603.1\|WP_085094779.1\|1120785_1121055_+\|YdeI/OmpD-associated-family-protein	gnl\|CDD\|379149	pfam13376, OmdA, Bacteriocin-protection, YdeI or OmpD-Associated. This is a family of archaeal and bacterial proteins predicted to be periplasmic. YdeI is important for resistance to polymyxin B in broth and for bacterial survival in mice upon oral, but not intraperitoneal inoculation, suggesting a role for YdeI in the gastrointestinal tract of mice. Production of the ydeI gene is regulated by the Rcs (regulator of capsule synthesis) phospho-relay system pathway independently of RcsA, and additionally transcription of the protein is regulated by the stationary-phase sigma factor, RpoS (sigma-S). YdeI confers protection against cationic AMPs (Antimicrobial peptides) or bacteriocins in conjunction with the general porin Omp, thus justifying its name of OmdA, for OmpD-Associated protein.	2.64601e-18
NZ_AP022603.1\|WP_085094787.1\|1118342_1119020_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293792	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site.	1.53827e-44
NZ_AP022603.1\|WP_085094795.1\|1108005_1108200_-\|50S-ribosomal-protein-L35	gnl\|CDD\|234676	PRK00172, rpmI, 50S ribosomal protein L35; Reviewed.	2.87548e-21
NZ_AP022603.1\|WP_109750465.1\|1108244_1108907_-\|translation-initiation-factor-IF-3	gnl\|CDD\|234582	PRK00028, infC, translation initiation factor IF-3; Reviewed.	1.39501e-97
NZ_AP022603.1\|WP_085094775.1\|1124305_1124899_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133380	cd01105, HTH_GlnR-like, Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators. Helix-turn-helix (HTH) transcription regulator GlnR and related proteins, N-terminal domain. The GlnR and TnrA (also known as ScgR) proteins have been shown to regulate expression of glutamine synthetase as well as several genes involved in nitrogen metabolism. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	1.13815e-21
NZ_AP022603.1\|WP_085094771.1\|1125752_1126487_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133378	cd00592, HTH_MerR-like, Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators. Helix-turn-helix (HTH) MerR-like transcription regulator, N-terminal domain. The MerR family transcription regulators have been shown to mediate responses to stress including exposure to heavy metals, drugs, or oxygen radicals in eubacterial and some archaeal species. They regulate transcription of multidrug/metal ion transporter genes and oxidative stress regulons by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	1.28557e-16
NZ_AP022603.1\|WP_085094777.1\|1121118_1124097_-\|aminomethyl-transferring-glycine-dehydrogenase	gnl\|CDD\|235432	PRK05367, PRK05367, aminomethyl-transferring glycine dehydrogenase.	0
NZ_AP022603.1\|WP_163742235.1\|1109909_1113221_+\|bifunctional-lysylphosphatidylglycerol-synthetase/lysine--tRNA-ligase-LysX	gnl\|CDD\|235095	PRK02983, lysS, bifunctional lysylphosphatidylglycerol synthetase/lysine--tRNA ligase LysX.	0
NZ_AP022603.1\|WP_085094853.1\|1113369_1114764_+\|hypothetical-protein	gnl\|CDD\|223700	COG0627, COG0627, Predicted esterase [General function prediction only].	2.7667e-13
NZ_AP022603.1\|WP_109750466.1\|1105708_1106638_-\|adenylate/guanylate-cyclase-domain-containing-protein	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	1.62436e-28
NZ_AP022603.1\|WP_085094773.1\|1125167_1125665_-\|bifunctional-nuclease-family-protein	gnl\|CDD\|376830	pfam02577, DNase-RNase, Bifunctional nuclease. This family is a bifunctional nuclease, with both DNase and RNase activity. It forms a wedge-shaped dimer, with each monomer being triangular in shape. A large groove at the thick end of the wedge contains a possible active site.	3.52203e-63
NZ_AP022603.1\|WP_085094799.1\|1106758_1107511_-\|RNA-methyltransferase	gnl\|CDD\|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	6.06179e-68
NZ_AP022603.1\|WP_085094797.1\|1107552_1107942_-\|50S-ribosomal-protein-L20	gnl\|CDD\|179959	PRK05185, rplT, 50S ribosomal protein L20; Provisional.	2.87832e-57

>NZ_AP022603.1|WP_085094853.1|1113369_1114764_+|hypothetical-protein
MHGWIPVTAQVLAAVALVLAVGLRMRTRRWWLLSMPVAAAVGVGLALFARSYISSGGYAGDPAPRGLWIWTALTGLAAVVLVAGWPGSRWWRRAAAVCAVPLCLLSAGLALNLWVGYFPTVQTAWSQLTAGPLPDQTDEGTVSALAATAARTKTLPARGSVLKVDIPADGSGFRHRDELVYLPPAWFGSVPAPALPTVMMIGGEFNTPGDWLRTGAAIETVDAFAAAHDGNAPVLVFVDSGGQFNNDTECVNGPRGRAADHLVNDVRPYLISRFQVSAAAANWGVAGWSMGGTCAVDLVTMHPDKFSAFENIAGDIAPNAGTPEQTLRRLYNGDRAAAASFDPATVMSRHGRYAGISGRFDVNGTSRTAHGPAIINAAAGTLPGASDQLLAAQTLCGLGRANGIDCAVVEQPGRHDWPYAAAAFKASLPWLAGVLGTPGVDRVPVGYSEVTPDPAPRPVEAAGR
>NZ_AP022603.1|WP_163742235.1|1109909_1113221_+|bifunctional-lysylphosphatidylglycerol-synthetase/lysine--tRNA-ligase-LysX
MRSVSPPPQAGRTGGSFAWVPAAVAAFIGVIATLSLIASVSPLFRSVIEVPREYVNDYIFNFPDTSFAWAFVLALLAAALGARKRIAWWILVGYLAASIILNIAGLGDAHEGAVQEAGEIIGLATQIVALILVGLAYRQFWARVRRAALVKAVATLIAGMAVGIGLGWGLVELFPGTLTRADRLPYVVNRVVAFSGFGNDAFDGHTHIWVNALLGLFGALALMVAAIVLFRSQRADNALTGDDETAIRALLDQYGKDDSLGYFATRRDKSVVFAPNGRAAITYRVEVGVCLASGDPVGDRRAWPAAIAEWLRLCRSYGWAPGVMGASAAGAKAFHDAGVNALELGDEAILHPDRFKLSGPEMAPVRQAVTRARRAGLTVRIRRHRDLSPAQLAEVIGHADAWRDTETERGFSMALGRLGDPDDGDCLLVEAVREVADGAVAGEVAGEVVAMLSLVPWGATGVSLDLMRRSRQSPNGTIELMVSELALQSERLGITRISLNFAMLRSAFEEGAQLGAGPVARLWRRLLMFFSRWWQLESLYRSNMKYGPEWVPRYFCYSDARLVPRVGVASVIAEGFLVLPFSRRNEQHTGQHSTVPRNVAAEAPTADHGTEDPAVGADGRRLPEQVRVRMAKLQELTRRGVDAYPAGEPPSHTVEQALAAADGTAVTVAGRILRMRDYGGVLFAQVRDWSGEVQLLLDDSAGCPVQDFTGAIDLGDLVEASGTIGVSRNGTRSLLVTGWRLIGKCLRPLPDKWKGLTDPEARVRARYVDLAVNPDSRALITARSQILRAIRDTLFDDGFLEVETPILQQIHGGANARPFRTHINAYDLDLYLRIAPELYLKRLCVGGVERVFELGRAFRNEGVDFSHNPEFTLLEAYQAHADYRSWIDGARALIQNAAIAANGSATVLRPDADGRLCPVDISGQWPVIAVHDAVSAALGEHVEPGTDLATLRRWCDAAGIGYQDGWDAGAVVLEMYEHLVEDRTEAPTFYIDFPASVSPLTRPHRSRPGLAERWDLVAWGVELGTAYSELTDPVLQRRRLQEQSLLAAGGDPEAMELDEDFLQALEYAMPPTGGLGMGVDRVVMLITGRSIRETLPFPLAKPR
>NZ_AP022603.1|WP_109750464.1|1109501_1109837_+|hypothetical-protein
MPADDVPSAPEVVDDAVEPLEATIVDAAVVFEPVETGALPADAGYDARGVPTFEMVREKIETRFGTSVGATELASETPEGRRVEEQFDARQQAATEKLEQIRRSMKAAEDS
>NZ_AP022603.1|WP_085094791.1|1109129_1109483_+|hypothetical-protein
MTDDPRIEDQAPVRELAEIPAVEVITRSAVMLMSAAAEKIGLSAEDPDNSPHRDLDEARRLITALAGLVTASLEYLGPHAGPLRDGLKSLQLAFREASVDPEEPGHGPGEKYTGPVW
>NZ_AP022603.1|WP_109750465.1|1108244_1108907_-|translation-initiation-factor-IF-3
MERSHWLPAPARSDTDRPSQGGHISTETRVNERIRVPEVRLIGPGGEQVGIVRIEDALRVAADADLDLVEVAPDARPPVCKIMDYGKFKYETAQKARESRKNQQQTVVKEQKLRPKIDDHDYETKKGHVTRFLQAGSKVKVTIMFRGREQSRPELGFRLLQRLGTDVAEYGYIETSAKQDGRNMTMVLAPHRGAKTRAQAAEQSGGQAGGPAGDGNATGS
>NZ_AP022603.1|WP_085094795.1|1108005_1108200_-|50S-ribosomal-protein-L35
MPKAKTHSGASKRFRRTGTGKIVRQKAGRRHLLEHKASKRTRRLDGRTEVSANDHARINKMLNG
>NZ_AP022603.1|WP_085094797.1|1107552_1107942_-|50S-ribosomal-protein-L20
MARVKRAVNAQKKRRSVLKASKGYRGQRSRLYRKAKEQQLHSLTYAYRDRRARKGEFRKLWISRINAAARANDITYNRLIQGLRLAGVEVDRKNLAEIAVSDAAAFTALVEVARAALPADVNAPSGEAA
>NZ_AP022603.1|WP_085094799.1|1106758_1107511_-|RNA-methyltransferase
MVAAAKLLRHPGRKRAGRFLAEGPNLVQGALARGLALELFATAEAAERHADLLAGAPIPVHPVTARAAKALSETVTPPGLVAVCAVPDTTVADLSEPRLVLVAVGLSEPGNAGTMIRTAHAMGADAVVLVGHSVDPYNGKCLRSSAGSIFGIPVLVEPDADAALAALRAAGLQTLATTLDGEIDLDDADGLLAAPTAWVFGPEAHGLPGALAAAADHRVRIAMPGDAESLNVASAAAICLYLSARARRRR
>NZ_AP022603.1|WP_109750466.1|1105708_1106638_-|adenylate/guanylate-cyclase-domain-containing-protein
MAGPGGTTYPDRVDLQPREDDADAGTGALARPEPAAGSAVASAAAWLAGTNHNPALVSFIRRARRMLPGDPEFGDPLSTAGDDAPSTAARAADRFIRDREAASREVGLAGLQVWQAVAGLVSRTPSNAEVTIVFTDLVGFSTWSLAAGDDATLRLLRKVAAAIEPPLLDRGGHIVKRMGDGLMAVVRRPDVALAGVLAANDALAEVQVDGYTPRMRAGLHTGHPQRIGGDWLGVDVNIAARVMERASRGGVMISGDTLDRIAPEQLDALGVRPKKVRRQLFTAKPSGVPDGLLMYRLQPTARHAVDDDD
>NZ_AP022603.1|WP_085094803.1|1104051_1105632_+|FMN-binding-glutamate-synthase-family-protein
MKRALPIGVIWIVGATALWLALTASPWWVAVAVPLLLLAALGTHDLLQRRHAILRAYPILGHARFLMEELRPEIRQYFIESDTADTPFAREIRDIVYERAKGTKSEEPFGTQRDVYEPNHEFVPHSLRARFATEPAPRVRLGGPDCTQPYDIALLNVSAMSFGALSAQAIEALNAGAARGGFAHDTGEGGMSPYHLKPGGDLIWEIASAYFGCRTAEGAFDPELFEAKAATPAVKAISIKLSQGAKPGLGGVLPGAKVTEEIAATRGVPVGQTVISPPTHSAFGTPLELVEFIATLRRLSGGKPVGIKLCVGARSEFLSICKAMLATGITPDFIIVDGAEGGTGAAPQEFEDFVGLPLTEGLMLVHNALVGVGLRGRIRIGASGKVATGFDIVSRVVQGADFTLAARAMMFAVGCIQARKCHTNACPTGVATQDPERSRAIDVPDKSARVYNFQKATVASAAQLVASMGLGGFAELTPAMLHRRIDSRRTASYAELYDWLDDGELLSHPPKPWRDDWERARPDAFV
>NZ_AP022603.1|WP_085094787.1|1118342_1119020_+|MBL-fold-metallo-hydrolase
MTVVSDSYTGHVDAGTGARRRLPGATIIKLSVGPMDNNAYLISCANTGKTLLIDAANDADTLRAVIAEDAPDVALILTSHQHLDHWQALEAVAAATGAPTAAHELDAGGLPVRPDRLVADGDTIEVGDLRFTAIHLRGHTEGSVALALGGDATGGVTQIFSGDCLFPGGVGKTWADGDFERLLGDVSTKLFDRYGDDTVIYPGHGDDTTLGAERPHLQEWRTRGW
>NZ_AP022603.1|WP_085094785.1|1119114_1119558_-|universal-stress-protein
MSGYKTVLVGTDGSDSSLLAVERAGALASGEGSKVVIATAYFPTHDDSRAADILKDEGYKMTGNAPIYAILQEATERAKAAGAFAVEERAIVGAPVDALVELSGDIDADLLVVGNVGLSTIAGRLLGSVPANVARKAKCDVLIVHTS
>NZ_AP022603.1|WP_085094783.1|1119830_1120211_+|phage-holin-family-protein
MGDFLLRTALVGVALWVVSLIVPGVSFVGGDSTAARVGIIFVVAVIFGLVNAVIKPIVQLLAIPLYILTLGLIHVVINALMLWITSWITEHTTHWGLQVDPFWWQAIWGAIVLSLVSWGLSTLVRG
>NZ_AP022603.1|WP_085094781.1|1120260_1120728_+|hypothetical-protein
MSTLNGLPAHVLLVHFTLVLGALTAILAILCAVWPAARRRFVWLTLTLAAVTAVLTPLTMEAGEWLEDRVTGSEALERHEDLGKTMLYVAIALVIAAILVAVLHRWAMPTVPAVLVAVVVVALSVGAAAQLMRIGESGAEAAWGEVVSGSSADGD
>NZ_AP022603.1|WP_085094779.1|1120785_1121055_+|YdeI/OmpD-associated-family-protein
MSPASIPGGVVHDLPDDLAAALGANAVALDAWRDITPLARNEFICWVTDAKQAATRARRIRRTQEELEEGKRRPCCWPGCAHRERTGKP
>NZ_AP022603.1|WP_085094777.1|1121118_1124097_-|aminomethyl-transferring-glycine-dehydrogenase
MGKGPPAAGRISQAPGCGWTTEGEERRFFGVSVVREEPPVTDLPATASVARFVDRHIGPDAADLAAMLDVIGVASLDELAAKAVPAGIFDTLGAGGLAPGLAELPPPATEHQALGELRELARANTIAVSMIGQGYYDTLTPPVLLRNIVENPAWYTAYTPYQPEISQGRLEALLNFQTMIADLTGLDLANASMLDEATAAAEAMTLMHRVGKGKRQRLLVDTDVFAQTAAVLATRAEPLGIEIVTADLHAGLPDGLAAGEFFGVIAQLPGASGRVTDWSALAEAAHRAGALLAIGADLLAATLITSPGEMGADVAFGSSQRFGVPMGFGGPHAGYLAVHDRHARQLPGRLVGVSVDADGAPAYRLALQTREQHIRRDKATSNICTAQVLLAVVAAMYASYHGPDGLAAIAARVHGHAARIAAALGPAVVHDNFFDTVLVRVPERADAVIAAAKARGINLWRADADHVSLSCDEATSDAHVAAVLEAFGAEPAAAAPAGGPEPARTSSYLTHPAFHDYRTETSMMRYLRALSDKDLALDRTMIPLGSCTMKLNAAAEMEPITWPEFSRQHPFAPASDTPGLRKLIADVTDWLTLVTGYDAVSLQPNAGSQGEYAGLLAIHAYHGARGESHRDICLIPSSAHGTNAASAALAGMRVVVVGCRENGDVDLDDLRAKIAEHAANLSAIMITYPSTHGVFEHDITDICAAVHDAGGQVYVDGANLNALVGLARPGRFGGDVSHLNLHKTFCIPHGGGGPGVGPVAVRAHLTPYLPGHPMAPGLAGGAPVSAAPYGSASILPITWAYIRMMGAAGLREATLTAIASANYIARRLDEYFPVLYTGENGMVAHECILDLRGITKDTGVTVDDVAKRLADYGFHAPTMSFPVAGTLMVEPTESESRAEIDAFCEAMIAIRGEIDKVGAGLWPVEDNPLRGAPHTAESLLVADWAHPYTREEAAYPLGAGYRPKVWPPVRRIDGAFGDRNLVCACPPVASYS
>NZ_AP022603.1|WP_085094775.1|1124305_1124899_-|MerR-family-transcriptional-regulator
MGEEPRQGQLDLGTSHGAAVQPGLFPDDSVPDELIGYRGPSACQIAGITYRQLDYWARTSLVVPSIRGAAGSGSQRLYSFKDVLVLKIVKRLLDTGISLHNIRVAVDHLRQRGVQDLANITLFSDGTTVYECTSAEEVVDLLQGGQGVFGIAVSGAMRELTGTIADFPGERADGGEAIAAPEDELASRRRGRDRKTG
>NZ_AP022603.1|WP_085094773.1|1125167_1125665_-|bifunctional-nuclease-family-protein
MGEVLVVGIRVEQPQNQPVLLLREANGDRYLPIWIGQSEAAAIALKQQGVEPARPLTHDLIRDLITALGHTLSGVRVVDLQEGTFFAELVFDDGEVTVSARPSDAVAIALRVGVPIHVEEAVLAEAGLFIPDESDEQDSGPVREDEVEKFKEFLDSISPDDFKAT
>NZ_AP022603.1|WP_085094771.1|1125752_1126487_-|MerR-family-transcriptional-regulator
MTAPDTPGIPGMSIGAVLAELLPDFPDVTVSKIRFLETEGLVTPARTAARYRQYTAYDLARLRYILTAQRDNYLPLKVIKAELDAQPDGELPAAATSYGAPRLVGAEPAVPARVVRLSREDLVEASGIARGRAEDLLTALTKAGVITPIFKGRGAVLFDEHSVVILQCANALADFGVEPRHLRAFRSAADRQSDLIAQIAGPLVKTDKAGARDRADDLAREVAALAITLHTSLIRSAVRDALQR
>NZ_AP022603.1|WP_085094769.1|1126486_1126933_-|FHA-domain-containing-protein
MTDYNDDTSDEVSVETTSVFRQDFLKELDAPAAGSGESAVSGVEGLPVGSALLVVKRGPNAGSRFLLDQPVTSAGRHPDSDIFLDDVTVSRRHAEFRLENGEFQVVDVGSLNGTYVNREPVDSSVLSNGDEVQIGKFRLVFLTGPKTD

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Crispr_ID: NZ_AP022603_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022603_7

1483670-1483763

Orphan

Consensus_repeat	Method
TGGTGCCGGTGGTGAGCGTGGTGC	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_AP022603_7

>merge|NZ_AP022603|7|1483670-1483763|CRISPRCasFinder
TGGTGCCGGTGGTGAGCGTGGTGCGCGTCCCACCGCGCTGCGCGTGTGCGTCGAGGCCGCCTGGTACGCATGGTGCCGGTGGTGAGCGTGGTGC

>NZ_AP022603|7|5|1483670-1483763|CRISPRCasFinder
TGGTGCCGGTGGTGAGCGTGGTGC	GCGTCCCACCGCGCTGCGCGTGTGCGTCGAGGCCGCCTGGTACGCA
TGGTGCCGGTGGTGAGCGTGGTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022603.1\|WP_085100556.1\|1480149_1480953_-\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	unknown	unknown	gnl\|CDD\|223692
NZ_AP022603.1\|WP_109750638.1\|1483991_1484489_-\|LppP/LprE-family-lipoprotein	unknown	unknown	gnl\|CDD\|379436
NZ_AP022603.1\|WP_085100559.1\|1478813_1480121_+\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270303
NZ_AP022603.1\|WP_085100561.1\|1478001_1478817_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_AP022603.1\|WP_085100814.1\|1493314_1494712_-\|glycine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235240
NZ_AP022603.1\|WP_085100542.1\|1486995_1487298_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085100545.1\|1485047_1486958_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173839
NZ_AP022603.1\|WP_085100529.1\|1491287_1493303_+\|TPM-domain-containing-protein	unknown	unknown	gnl\|CDD\|377378
NZ_AP022603.1\|WP_163742307.1\|1472625_1472766_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|183626
NZ_AP022603.1\|WP_085100525.1\|1494867_1495212_+\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_AP022603.1\|WP_085100533.1\|1489991_1491251_-\|deoxyguanosinetriphosphate-triphosphohydrolase	unknown	unknown	gnl\|CDD\|235098
NZ_AP022603.1\|WP_085100536.1\|1489410_1489929_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085100539.1\|1487396_1489343_-\|DNA-primase	unknown	unknown	gnl\|CDD\|235551
NZ_AP022603.1\|WP_085100548.1\|1484535_1484769_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085100564.1\|1477148_1478015_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_AP022603.1\|WP_085100570.1\|1474089_1475463_-\|peptidase	unknown	unknown	gnl\|CDD\|223389
NZ_AP022603.1\|WP_085100554.1\|1480949_1483154_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213192
NZ_AP022603.1\|WP_085100551.1\|1483178_1483628_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_AP022603.1\|WP_085100567.1\|1475462_1476977_-\|TldD/PmbA-family-protein	unknown	unknown	gnl\|CDD\|223389
NZ_AP022603.1\|WP_109750639.1\|1473241_1474045_-\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039

Protein	Function_ID	Function_description	E-value
NZ_AP022603.1\|WP_085100556.1\|1480149_1480953_-\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	5.18777e-26
NZ_AP022603.1\|WP_109750638.1\|1483991_1484489_-\|LppP/LprE-family-lipoprotein	gnl\|CDD\|379436	pfam14041, Lipoprotein_21, LppP/LprE lipoprotein. The family includes putative lipoproteins LppP and LprE from species of Mycobacterium. LppP is required for optimal growth of M. tuberculosis.	2.21536e-31
NZ_AP022603.1\|WP_085100559.1\|1478813_1480121_+\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.51867e-60
NZ_AP022603.1\|WP_085100561.1\|1478001_1478817_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.3429e-77
NZ_AP022603.1\|WP_085100545.1\|1485047_1486958_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173839	cd01150, AXO, Peroxisomal acyl-CoA oxidase. Peroxisomal acyl-CoA oxidases (AXO) catalyze the first set in the peroxisomal fatty acid beta-oxidation, the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. In a second oxidative half-reaction, the reduced FAD is reoxidized by molecular oxygen. AXO is generally a homodimer, but it has been reported to form a different type of oligomer in yeast. There are several subtypes of AXO's, based on substrate specificity. Palmitoyl-CoA oxidase acts on straight-chain fatty acids and prostanoids; whereas, the closely related Trihydroxycoprostanoly-CoA oxidase has the greatest activity for 2-methyl branched side chains of bile precursors. Pristanoyl-CoA oxidase, acts on 2-methyl branched fatty acids. AXO has an additional domain, C-terminal to the region with similarity to acyl-CoA dehydrogenases, which is included in this alignment.	2.41953e-179
NZ_AP022603.1\|WP_085100529.1\|1491287_1493303_+\|TPM-domain-containing-protein	gnl\|CDD\|377378	pfam04536, TPM_phosphatase, TPM domain. This family was first named TPM domain after its founding proteins: TLP18.3, Psb32 and MOLO-1. In Arabidopsis, this domain is called the thylakoid acid phosphatase -TAP - domain and has a Rossmann-like fold. In plants, the family resides in the thylakoid lumen attached to the outer membrane of the chloroplast/plastid. It is active in the photosystem II.	8.3921e-19
NZ_AP022603.1\|WP_163742307.1\|1472625_1472766_-\|hypothetical-protein	gnl\|CDD\|183626	PRK12618, flgA, flagellar basal body P-ring formation protein FlgA.	0.0062652
NZ_AP022603.1\|WP_085100525.1\|1494867_1495212_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	2.48522e-15
NZ_AP022603.1\|WP_085100533.1\|1489991_1491251_-\|deoxyguanosinetriphosphate-triphosphohydrolase	gnl\|CDD\|235098	PRK03007, PRK03007, deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional.	0
NZ_AP022603.1\|WP_085100814.1\|1493314_1494712_-\|glycine--tRNA-ligase	gnl\|CDD\|235240	PRK04173, PRK04173, glycyl-tRNA synthetase; Provisional.	0
NZ_AP022603.1\|WP_085100539.1\|1487396_1489343_-\|DNA-primase	gnl\|CDD\|235551	PRK05667, dnaG, DNA primase; Validated.	0
NZ_AP022603.1\|WP_085100564.1\|1477148_1478015_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	3.87447e-83
NZ_AP022603.1\|WP_085100570.1\|1474089_1475463_-\|peptidase	gnl\|CDD\|223389	COG0312, TldD, Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only].	6.13396e-40
NZ_AP022603.1\|WP_085100554.1\|1480949_1483154_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	1.23478e-60
NZ_AP022603.1\|WP_085100551.1\|1483178_1483628_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	7.1729e-16
NZ_AP022603.1\|WP_085100567.1\|1475462_1476977_-\|TldD/PmbA-family-protein	gnl\|CDD\|223389	COG0312, TldD, Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only].	7.66133e-101
NZ_AP022603.1\|WP_109750639.1\|1473241_1474045_-\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	7.18014e-07

>NZ_AP022603.1|WP_085100551.1|1483178_1483628_+|MarR-family-transcriptional-regulator
MTFDRTASQRELGPRLLSAVTRLNRLATQRTRLPLPWAQARLLSTIESSGSARISDLAALDHCSQPTMTTQVRRLEDAGLVTRTADPGDARAVLIAITDAGVAALARARTDRAAGIDPLLDQLDDAEREVLAEATEIMDRLLKLASQRS
>NZ_AP022603.1|WP_085100554.1|1480949_1483154_-|ABC-transporter-ATP-binding-protein
MYINRRGDDFFTVGDRPGRSAGRGRVPRSFWAGRIGPVIADSSTAQRRPSRSLTPAELAQAAVTAALCAACAVIAVVVPFAQSVALLGMVPMGLLSYRYRLRVLLAAAFAGAGIAFLVAGVGGMMTVVISAYIGGLTGIVKRRGRGTPTVIAASFVAGVGFGGFAVAALAALSRIRELIFATINANFEGTARFLEAMAKAADWAANRSGGSQSSALAEAIRAPADPLRAFVATAVNYWPLLVGGYAVFTIMMVTLIGWWALSRVLERLRGIPDVHKLDAPPPGPPGPVPITLRGVRFRYPGAEHDALAPIDMEIAAGENVAVTGANGSGKTTLMLILAGREPTAGTVERPGAVALGAAGGTAVVLQHPETQVLGTRVADDVVWGLPPGQRVDVDGLLAEVGLSGMADRDTGGLSGGELQRLAFAGALAREPRLLIADEVTSMVDQAGRDALMGVLSGLTTRHAMSVVQITHYTGEADAADRIISLSDSVDNTTMVQTASVPAAAAPAAGSGQTVLECRGITHAYGAGTPWAKTALRDIDFSVAAGDGVLIHGGNGSGKSTLAWIMAGLITPTTGECLVAGRPAREQHGQVAVAFQAARLQLMRPRVDLEVASAAGFSPGDRRRITEALATVGLDGSLARRRIDQLSGGQMRRVVLAGLLARRPRVLILDEPLAGVDAVNQGKLLRLLEDLRRDTGLTVVVISHDFVGLQGLCPRILHLNGGVLEPASAAAGGGA
>NZ_AP022603.1|WP_085100556.1|1480149_1480953_-|energy-coupling-factor-transporter-transmembrane-protein-EcfT
MSRAEKQSRPVVLLRPVPGNSVIHELWAGTKLIAVFAFSVLLTFFPGWLPILLVGAVVLVAARIARVPFGALPSIPKLMWVLLAIGAGTAALGGGEPLVHVFGIDVALGGLLAFTRVTLLAVVLLGLSMMVSWTTNVADIAPAIATLGRPLKLLRIPVDEWATATALALRSFPMLVDEFRVLYAARRLRPRAQLPTRRMRWRRFGFELVDLLVAAITAALRRADEMGDAITARGGIGQISASTARPARRDALALVVVAAVCVLAALL
>NZ_AP022603.1|WP_085100559.1|1478813_1480121_+|sugar-ABC-transporter-substrate-binding-protein
MRTRFSTRLAVALVCLFALLLGAAVLLGREPGASGRVVLTLRLWDPRVAAAYRDSVQAFAAANPDIEVRIDTVPYANYFDTLRTDVAGGAAPDVFWLNSTNLAGYADSGRLHPIDPRPGWEPAVVDQFTRAGTLWGVPQLTDAGIAVYYNEDLLAAAGLTPADLAELSWGDGAADTLRPVLARLTVDAAGRRATDPGFDAGRTRIWGYNAANDLQAINLNFVGSAGGSFAEGDAFTFDNPAAITAFEYLVGLINTDHVAPPASDTNDNGDFSRNQFLAGRLALFQSGTYNLANIADAAGFRWGVAPMPAGPAGRVSVTNGIVAAGNAASVHPDRVRRLLDWLGSTEGNAFLGAGGATIPAVRQAQRGYFDHWSARGVDVRPFFEVVDGPHIEVPAGAGAAAGLTAIRPFFDEMFLGRLPVPSALRDAQAAANRRS
>NZ_AP022603.1|WP_085100561.1|1478001_1478817_+|carbohydrate-ABC-transporter-permease
MTSPRSGWIYLALAAAAVITVAPFGLGLLTSVTSAQQFATAAPLSWPSPPTLENYAALSGAGFGRAAMVTALMTAVILVGQLSSSVLAAYAFARLDFPGRDALFWVYLATLMVPATVTVVPLYLMMGSLGLRNTFWALVLPFVFGSPYAIFLLREHFRSIPRDLERAARLDGANTLDVLVHVILPASRPILVTLALITVVSQWNSFMWPLVITSGGKWRVLTVATAGLQSQYNAQWTTVMAATTVAIVPLLVLFVVFQRHIVRSIVVTGLK
>NZ_AP022603.1|WP_085100564.1|1477148_1478015_+|sugar-ABC-transporter-permease
MIRRRETTLAYALLAPSLFGVLAFLLLPMLVVVWLSLRSWDLLGPIENVGLDNWGSVLTDAAFGNSLLVTLGFIALVVPAQLLLGLGIAALLARELPGSGFFRTVYVLPWICAPLAIAVLWRWILAPTDGAVSAMLGHRIEWLTDPGLALPVVSAVTVWTNVGYVALFFLAGILAIPADVLDAARIDGATGWQRFTRIIMPMLRPTLFFVAVTGVISAAQVFDTVYALTGGGPRGRTDLVAHRIYDEAFGSAAIGRAAVMAIVLFVVLVAITIAQHRYFRRRISYDLT
>NZ_AP022603.1|WP_085100567.1|1475462_1476977_-|TldD/PmbA-family-protein
MTARTIDADFLALPHRALADAALSAAVQTGASYADLRVHRITSEIIQLRDGELETSVLTRELGLAVRVIVAGTWGFASHAELSAEVAADTARRAVEVANSLAALNAEAIELAEEPVYENAMWTSSYEIDPFEVPGAEKIAVLAEYSGRLLASDGVDHVSAGLHAVKEQTFYADTFGSSITQQRVRVLPTLDAVSVDPAAGHFESMRTLAPPMGRGWEVVAGDRVWDWSTELARLPELLAEKTKAPSVTAGVTDLVIDPTNLWLTIHESIGHATEYDRAIGYESAYAGTSFATPDKLGSMRYGSPVMTVTADRTVEHGLATIGFDDEGVAAQSWDLVRDGIFVGYQLDRVFAPRLGRSRSNGCSYADSPHHVPIQRMANVSLAPAAEDIATEDLISRVDDGLYIVGDKSWSIDMQRYNFQFTGQRFYRIRNGRLAGQVRDVAYQSSTTDFWNSMEAVGGPSTWRLGGAFNCGKAQPGQVAAVSHGCPSALFRGVNVLNTVAEAGH
>NZ_AP022603.1|WP_085100570.1|1474089_1475463_-|peptidase
MIPAAQVVELALAAAACAGGADETIVLVTDTATAALRWAGNTMTTNGVSTSRTTTVISIVRRGGRAHVGSLASAEVDREAIPALVAASQAAARSAPAARDSFPLLPADPAGVGWDEPAPGTGAEVFAPVAEALARGFTGPDTLYGFAHHVVETTWLATSTGLRRRSVQPTGSVEINAKRNGASAWAGVSTPWFDDVATDDLLAELAMRLGWAQRTVELPAGHYETIMPPSTVADMMIYLGWTMDGRGAQEGRTALAAPGGGTRVGERLTDLGLTMYSDPAAPGLECTPFLAVGSSSETTSVFDNGLDLTRVDWIRDGSIAALAYPRAAALEFDVPVAIPSSNLLMTGGDAELADMVAGTERGLLLTTLWYIREVDPTSLLLTGLTRDGVYLIEDGEVSAAVNNFRFNESPLDLLRRATEAGRAEKTLPREWGDWFNRASMPSLRIPDFHMSSVSQAQ
>NZ_AP022603.1|WP_109750639.1|1473241_1474045_-|carboxymuconolactone-decarboxylase-family-protein
MLADLTRLVALSPPKFADLNAAVREVCAATIGCPPLPAESRGGPVDPMITEFAEQFSADVSAITAAQRAAYTESLGADVATVTLLIYLADFVPRVAAGLRSLGVDWSPQAGDWDHHTDPAALLLGRMVGRIGQLTDLDPVSTEVVRLRVARAHNCRLCKSLRERSALEAGGSEDLYDGIDDYSHSSVLSPAHRAALRYTDALLWTPAQIDGAELLAHYDRDAAVELTFDVLRNSCNKIAVSLGADAARVSEGTEGYRIGPDGLPIYG
>NZ_AP022603.1|WP_163742307.1|1472625_1472766_-|hypothetical-protein
MDSKVLFSHPDDTTAPAVVNDNDVAPLVFSDAPKKQSGRHSDRPGQ
>NZ_AP022603.1|WP_109750638.1|1483991_1484489_-|LppP/LprE-family-lipoprotein
MGVLRVLVGLAAVVLLTLTGCGWSPSGPEPTPPDSCTAADAPSADTINRAMDGLAAAPGEASWTETGRGYSRDCRLHWVQVSPSGATASSPGQVLFFDRNNYLGTPTPDPKPYLTVLAAGDDTVTLQYQWLQGDEPNCCPTGIGTVRFTVGDDGRLKSLDPVPVN
>NZ_AP022603.1|WP_085100548.1|1484535_1484769_-|hypothetical-protein
MLGYVAVLGVGYVLGTKAGRRRYEQIVGAYKAVTTNPATKSVVDAGRRKIARSVSPDPMATITEIDDITVIEPPKEK
>NZ_AP022603.1|WP_085100545.1|1485047_1486958_-|acyl-CoA-dehydrogenase-family-protein
MATIAEHLRNTLDGRWREVKNRMRAELATEVFRPRYTPNTMIARSRVNEQLRLMTDTGAAADSFGTAHGGTGEVGAAIAGIEMVAMADLSLMVKAGVQWGLFGGAVENLGTERHHRAYVRRIIDLDLLGCFAMTETGHGSDVQSLETTAEYDPATEEFVINSPTPSSRKDYIGGAAESAREAVVFAQLITPDGKCHGVHALVVSLRGADGADLPGVTTSDCEYKGGLPGVDNGRIMFDQVRVPRENLLNRYADVAADGTYSSPIENPDRRFFTMLGTLIRGRVTVGGSAAAAARVALDIATRYALSRRQFEAPGQDQEVLIMDYLVHQRRLLPLIARSYALQFAQNELVSKCHDLQTAADPDPEEQRELEARAAGLKAANTWHATRAIQEAREACGGAGYMAENRLIALKADTDVFTTFEGDNHVLTQLVAKELLTGYADDIKSMSPAGWVRFAANYAGERVLKRTAAETIVQTILDTRQDNEEEGSLFNRGTQLAMFEDREEYLLASVARRLQGKSKEMSEFDAFNAVQDHVLHAASAHIDRVILEAFIAGIDCCPDDDARRILSMVCDLYALSVIEDDKAWFMEHRFLSTERAKAVTRGINERCRTLRPHAEVLVEGFGVPEQCRRVEMLTPGQ
>NZ_AP022603.1|WP_085100542.1|1486995_1487298_-|hypothetical-protein
MAAKFAARRLVAVAALAAAAVAGPAIAALSSSDTPAYDAQPGGKCLAWLGAKGTGTCIGRSNSNSGGITVGTPGIGLGNGGIYSGPIMPGSSVGGTIPIG
>NZ_AP022603.1|WP_085100539.1|1487396_1489343_-|DNA-primase
MAGRISDRDIAAIREKVRIEDVVGDYVQLRRAGADSMKGLCPFHDEKSPSFHVRPNHGHFHCFGCGEGGDVYAFLQKIEHVSFVEAVELLADRVGHTITYTGASATNVQRDRGSRSRLIAANAAAAEFYAGELGSEEAATARKYLTDRNFDAAAAHQFGCGYAPSGWDRLTKHLLRKGFEFKELEAAGLSREGRRGPMDRFHRRLLWPIRGSSGEVLGFGARRLYDDDPMEAKYVNTPETVLYKKSNVLFGIDLAKRDIAKGHQAVVVEGYTDVMAMHLSGVTTAVASCGTAFGDEHLSMLRRLMMDDSFFRGELIYVFDGDAAGRAAALKAFGGEQNLAGQSYVAVADDGMDPCDLRLAHGEVALRDLVARRTPLFEFAIRTALTEFDLDTVEGRVSALRRCVPMLAQIKDPTLRDEYARQLAGWVGWDDVAQVIRRVRDVARGGAGAAASGRGAGSGRGRAGGRAEARDGTVAERPAGPSAGRPDPRDPTLWPQREALKSALQYPGLAGPVFDSLDADSFTHPGYLAVRTAIVAAGGSSAGESGPTWIEQVRAQTAAPAAAALVSELGVESINVDEAKLPRYISGVLARLQEVWVGRQIAEMKSKLQRMSPIEDSEEYHELFGDLVAMESYRRSLLQQASGDDLTA
>NZ_AP022603.1|WP_085100536.1|1489410_1489929_+|hypothetical-protein
MTYPAAPPAPPLPRWWRWAMTVPTVAAGLAILALLAAVLGLGEPLLILLFAGCALVGCGLAWLILTILGLLRHPGRRHRVLTRALPAVLIVAVALPALAAVPRLRWSLSRAAMERAATECPQTSSPRWVGTIRLAKIHRMAGSCYLFEAGSFLTETGWVLLPAAPPNRRGPA
>NZ_AP022603.1|WP_085100533.1|1489991_1491251_-|deoxyguanosinetriphosphate-triphosphohydrolase
MNTDIQDHYTDADRQRLVAEAPKAAGLPGTGNQRRGDFARDRARVLHCAALRRLADKTQVVGPREGDTPRTRLTHSLEVAQIGRGMAVGLGCDADLVDLAGLAHDIGHPPYGHNGERELNRLAVDYGGFEGNAQNFRILTRLEPKVFGPDGRSAGLNLTRAALDAVTKYPWPREPGRAGPTKFAFYDDDLPAARWVRDGAPSAWPCLEAQVMDWADDVAYSVHDVEDGVISGRIDLRVLADPDAAAALADLGDSTHGADYDDLLAAADRLSKMPVVAGVGRYDGTQRAAGALKRLTSELVGRFANAAIGATREVVGPGPLRRYDADLEVPPVVRAEVAALKTLALQFIMSDPRHLAIQRVQRERIAAVYEFLVSQAPRGLDPLLVPMFDDAADDGARHRVIVDQIASYTETRLEHILIS
>NZ_AP022603.1|WP_085100529.1|1491287_1493303_+|TPM-domain-containing-protein
MPIPRLLGALLAVLMTALLIAPSASAEPPLRTQTQITDSAGVLSAADQVRVQASLDRLFDKTGIKLWVVYVDDFDGKGWMAWAERTERLSDFGNDDALLAIAVKDRAFAFNVDPALTNNSSKLRDDVRRDRVEPALRGGDWAGAAIGAADGLAAGKSAGTGGAGMSLTSVLVILGILVLLAALTWGWLRVRGRRRRRDELAAARRVDPTDPAALAPLSLDALDGLSRDIVVDVDNAVRTSEHELTLATDEFGATRTAPFRDAVETAKTALAQAFTVRQTLDDSVPETPLQQRDLLNRVIIAAARADRELEAQTAAFEELRNLLINAPDRLDALTRETVALTARLEPAAITLDDLHRQYSDTALASVAGNVTEARDRVAFADATIATGRAQLSRPAGDQSELIDTIHAAEGALGQAATLLDAVDSAASDINRAITALPAGIVDIGRGIDAAAAQLAAPDTPRADELRAAREAAVAAVADAGARGEGDPLGVFGRLTAADATLDQILAAVDAQRAETEQQARILEQALFTASSRVKAVSDFVDTRRGSIGPEARTRLAEATRQLEAAQAKRAGNPGEAIAHANGASTLAAQAQALANDDVRASQQHYYGGGGRPGSGGSDIGSMIGGIIIGSMMRGGGGSWGGSWGGGRSAGRPGSYGGASRSSGNRYSGGRF
>NZ_AP022603.1|WP_085100814.1|1493314_1494712_-|glycine--tRNA-ligase
MASVIDTVVNLAKRRGLVYPSGEIYGGTKSAWDYGPLGVELKENVKRQWWRAMVTGRDDVVGLDSSIILPREVWVASGHVDVFHDPLVECLSCHKRHRQDHMQEAYLARKGAKAAITDPDDVPMAEIVCPDCGTKGQWTEPREFNMMLKTYLGPIESEEGMHYLRPETAQGIFVNFANVVTTSRKKPPFGIAQIGKSFRNEITPGNFIFRTREFEQMEMEFFVEPSTAPEWHKYWIETRLQWYVDLGINRDNLRLYDHPREKLSHYSDGTVDIEYMFGFAGSGWGELEGIANRTNFDLTTHSKHSGNDLSYYDQAADTRYVPYVIEPAAGLTRSFMAFLVDAYHEDEAPNAKGGVDKRTVLRLDPRLAPVKAAVLPLSRHADLSPKARDLAAELRQYWNIEFDDAGAIGRRYRRQDEIGTPYCITVDFDSLEDQAVTIRERDAMTQERVALGSVSDYLAARLKGC
>NZ_AP022603.1|WP_085100525.1|1494867_1495212_+|winged-helix-turn-helix-transcriptional-regulator
MTTEHGPGHGTAVSEAAAPDPALLEAAGDLLRALAAPVRIAIVLQLHERPRRVHELVNAVAVPQPLVSQHLRVLKAAGVVSGRRSGREMVYHLVDHHLAHIVLDAVAHAAEDHP

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Crispr_ID: NZ_AP022603_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022603_8

1796361-1796449

Orphan

Consensus_repeat	Method
CTAACCTTTTGCAGGCCCTGGCCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022603_8

>merge|NZ_AP022603|8|1796361-1796449|CRISPRCasFinder
CTAACCTTTTGCAGGCCCTGGCCGGCTTCGGCGTGACGCTGGGTCTCCGGGGGGCCACCCGTGGCTAACCTTTTGCAGGCCCTGGCCGG

>NZ_AP022603|8|6|1796361-1796449|CRISPRCasFinder
CTAACCTTTTGCAGGCCCTGGCCGG	CTTCGGCGTGACGCTGGGTCTCCGGGGGGCCACCCGTGG
CTAACCTTTTGCAGGCCCTGGCCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022603.1\|WP_085097801.1\|1788755_1789439_+\|NADH-quinone-oxidoreductase-subunit-C	unknown	unknown	gnl\|CDD\|181115
NZ_AP022603.1\|WP_085097811.1\|1786795_1787236_+\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|281995
NZ_AP022603.1\|WP_085097779.1\|1797666_1797966_+\|NADH-quinone-oxidoreductase-subunit-NuoK	unknown	unknown	gnl\|CDD\|180218
NZ_AP022603.1\|WP_085097761.1\|1805180_1806794_+\|NADH-quinone-oxidoreductase-subunit-NuoN	unknown	unknown	gnl\|CDD\|235603
NZ_AP022603.1\|WP_085097808.1\|1787851_1788214_+\|NADH-quinone-oxidoreductase-subunit-A	unknown	unknown	gnl\|CDD\|181171
NZ_AP022603.1\|WP_085097814.1\|1785649_1786267_-\|LpqN/LpqT-family-lipoprotein	unknown	unknown	gnl\|CDD\|378485
NZ_AP022603.1\|WP_085097794.1\|1791446_1792766_+\|NADH-quinone-oxidoreductase-subunit-NuoF	unknown	unknown	gnl\|CDD\|131014
NZ_AP022603.1\|WP_085097791.1\|1792768_1795138_+\|NADH-quinone-oxidoreductase-subunit-G	unknown	unknown	gnl\|CDD\|236118
NZ_AP022603.1\|WP_085097805.1\|1788204_1788759_+\|NADH-quinone-oxidoreductase-subunit-B	unknown	unknown	gnl\|CDD\|235797
NZ_AP022603.1\|WP_085097758.1\|1808364_1809630_+\|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha	unknown	unknown	gnl\|CDD\|376400
NZ_AP022603.1\|WP_085097891.1\|1786382_1786799_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_AP022603.1\|WP_085097773.1\|1800340_1800970_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372705
NZ_AP022603.1\|WP_085097798.1\|1789435_1790731_+\|NADH-quinone-oxidoreductase-subunit-D	unknown	unknown	gnl\|CDD\|180385
NZ_AP022603.1\|WP_085097764.1\|1803609_1805184_+\|NADH-quinone-oxidoreductase-subunit-M	unknown	unknown	gnl\|CDD\|235622
NZ_AP022603.1\|WP_085097770.1\|1800966_1801740_+\|slipin-family-protein	unknown	unknown	gnl\|CDD\|259808
NZ_AP022603.1\|WP_085097782.1\|1796938_1797670_+\|NADH-quinone-oxidoreductase-subunit-J	unknown	unknown	gnl\|CDD\|235844
NZ_AP022603.1\|WP_085097776.1\|1798004_1800344_+\|cbb3-type-cytochrome-c-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|225795
NZ_AP022603.1\|WP_085097767.1\|1801741_1803613_+\|NADH-quinone-oxidoreductase-subunit-L	unknown	unknown	gnl\|CDD\|235836
NZ_AP022603.1\|WP_085097796.1\|1790727_1791450_+\|NADH-quinone-oxidoreductase-subunit-NuoE	unknown	unknown	gnl\|CDD\|181024
NZ_AP022603.1\|WP_085097887.1\|1807037_1808180_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|368185

Protein	Function_ID	Function_description	E-value
NZ_AP022603.1\|WP_085097801.1\|1788755_1789439_+\|NADH-quinone-oxidoreductase-subunit-C	gnl\|CDD\|181115	PRK07785, PRK07785, NADH dehydrogenase subunit C; Provisional.	6.56917e-146
NZ_AP022603.1\|WP_085097811.1\|1786795_1787236_+\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	gnl\|CDD\|281995	pfam04075, F420H2_quin_red, F420H(2)-dependent quinone reductase. This family of proteins is found in the genera Mycobacterium and Streptomyces. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. Rv1558 is an F420H(2)-dependent quinone reductase involved in oxidative stress protection.	3.66873e-28
NZ_AP022603.1\|WP_085097779.1\|1797666_1797966_+\|NADH-quinone-oxidoreductase-subunit-NuoK	gnl\|CDD\|180218	PRK05715, PRK05715, NADH-quinone oxidoreductase subunit NuoK.	5.50761e-43
NZ_AP022603.1\|WP_085097761.1\|1805180_1806794_+\|NADH-quinone-oxidoreductase-subunit-NuoN	gnl\|CDD\|235603	PRK05777, PRK05777, NADH-quinone oxidoreductase subunit NuoN.	3.13878e-164
NZ_AP022603.1\|WP_085097808.1\|1787851_1788214_+\|NADH-quinone-oxidoreductase-subunit-A	gnl\|CDD\|181171	PRK07928, PRK07928, NADH dehydrogenase subunit A; Validated.	1.23957e-69
NZ_AP022603.1\|WP_085097814.1\|1785649_1786267_-\|LpqN/LpqT-family-lipoprotein	gnl\|CDD\|378485	pfam10738, Lpp-LpqN, Probable lipoprotein LpqN. This family is conserved in Mycobacteriaceae and is likely to be a lipoprotein.	0.000357028
NZ_AP022603.1\|WP_085097794.1\|1791446_1792766_+\|NADH-quinone-oxidoreductase-subunit-NuoF	gnl\|CDD\|131014	TIGR01959, NADH-quinone_oxidoreductase_subunit_F, NADH-quinone oxidoreductase, F subunit. This model describes the F chain of complexes that resemble NADH-quinone oxidoreductases. The electron acceptor is a quinone, ubiquinone, in mitochondria and most bacteria, including Escherichia coli, where the recommended gene symbol is nuoF. This family does not have any members in chloroplast or cyanobacteria, where the quinone may be plastoquinone and NADH may be replaced by NADPH, nor in Methanosarcina, where NADH is replaced by F420H2. [Energy metabolism, Electron transport].	0
NZ_AP022603.1\|WP_085097791.1\|1792768_1795138_+\|NADH-quinone-oxidoreductase-subunit-G	gnl\|CDD\|236118	PRK07860, PRK07860, NADH dehydrogenase subunit G; Validated.	0
NZ_AP022603.1\|WP_085097805.1\|1788204_1788759_+\|NADH-quinone-oxidoreductase-subunit-B	gnl\|CDD\|235797	PRK06411, PRK06411, NADH-quinone oxidoreductase subunit NuoB.	4.27775e-99
NZ_AP022603.1\|WP_085097758.1\|1808364_1809630_+\|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha	gnl\|CDD\|376400	pfam00848, Ring_hydroxyl_A, Ring hydroxylating alpha subunit (catalytic domain). This family is the catalytic domain of aromatic-ring- hydroxylating dioxygenase systems. The active site contains a non-heme ferrous ion coordinated by three ligands.	5.20907e-44
NZ_AP022603.1\|WP_085097891.1\|1786382_1786799_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	0.000744938
NZ_AP022603.1\|WP_085097773.1\|1800340_1800970_+\|hypothetical-protein	gnl\|CDD\|372705	pfam13751, DDE_Tnp_1_6, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	0.00470276
NZ_AP022603.1\|WP_085097798.1\|1789435_1790731_+\|NADH-quinone-oxidoreductase-subunit-D	gnl\|CDD\|180385	PRK06075, PRK06075, NADH-quinone oxidoreductase subunit D.	0
NZ_AP022603.1\|WP_085097764.1\|1803609_1805184_+\|NADH-quinone-oxidoreductase-subunit-M	gnl\|CDD\|235622	PRK05846, PRK05846, NADH:ubiquinone oxidoreductase subunit M; Reviewed.	0
NZ_AP022603.1\|WP_085097770.1\|1800966_1801740_+\|slipin-family-protein	gnl\|CDD\|259808	cd08826, SPFH_eoslipins_u1, Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model summarizes a subgroup of the stomatin-like protein family (SLPs or slipins) that is found in bacteria and archaebacteria. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Bacterial and archaebacterial SLPs remain uncharacterized. This subgroup contains PH1511 from the hyperthermophilic archaeon Pyrococcus horikoshi.	6.52943e-100
NZ_AP022603.1\|WP_085097782.1\|1796938_1797670_+\|NADH-quinone-oxidoreductase-subunit-J	gnl\|CDD\|235844	PRK06638, PRK06638, NADH-quinone oxidoreductase subunit J.	8.78012e-60
NZ_AP022603.1\|WP_085097776.1\|1798004_1800344_+\|cbb3-type-cytochrome-c-oxidase-subunit-I	gnl\|CDD\|225795	COG3256, NorB, Nitric oxide reductase large subunit [Inorganic ion transport and metabolism].	6.92599e-178
NZ_AP022603.1\|WP_085097767.1\|1801741_1803613_+\|NADH-quinone-oxidoreductase-subunit-L	gnl\|CDD\|235836	PRK06590, PRK06590, NADH:ubiquinone oxidoreductase subunit L; Reviewed.	0
NZ_AP022603.1\|WP_085097796.1\|1790727_1791450_+\|NADH-quinone-oxidoreductase-subunit-NuoE	gnl\|CDD\|181024	PRK07539, PRK07539, NADH-quinone oxidoreductase subunit NuoE.	1.78152e-84
NZ_AP022603.1\|WP_085097887.1\|1807037_1808180_-\|amidohydrolase	gnl\|CDD\|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	4.1797e-17

>NZ_AP022603.1|WP_085097791.1|1792768_1795138_+|NADH-quinone-oxidoreductase-subunit-G
MTDPQRDAPPVEMVTLTIDDQQVSVPKGTLVIRAAELIGVQIPRFCDHPLLEPVGACRQCLVEVEGQRKPMASCTITVAPEMVVRTQHTSADAEKAQRGVMELLLINHPLDCPVCDKGGECPLQNQAMSTGRPETRFDDVKRTFPKPIPLSEAVLLDRERCVLCARCTRFSTEIAGDPLIALLERGALQQVGIGAGEPLDSYFSGNTVQICPVGALTGTSYRFRARPFDLVSVPSVCEHCASGCAQRTDHRRGKVLRRLAGDDPEVNEEWNCDKGRWAFQYTRVGDRITTPLVRDGDALRPASWPEALAVAARGLSRARAAGVLVGGRSTVSDAYAYAKFARMVLGTNDIDFRARSHSPEEADFLAAAVAGRYRGLTYTQLQDAPAVVLAGFEPEEESPIVFLRLRKAVRTRGQQVIAIAPFASRGSGRLGAEVIATVPGDEAAALHALAGRLPAGAVILVGERLATSPGALSAAGALAAATGAQLAWIPRRAGERGALEAGCLPGLLPGGRPAHDPAARDQVAALWGIEALPDSPGRDTAGILSAVTAGDLDALLIGGVEPADLPAPGQARAALAAAGFVVSLELRESEVTAAADVVFPVAPVDEKAGAFLNWEARWRPFAAALPSNANTDLRVLAVLAAELGHDLGLSDATSVVGELTALGEWTGARIPAPATLGPGSRLPGPGEAVLAGWRMLLDRGRAQDGEQPLAATARPTVARLSASTAAGLGAAEGEPIVVSTEHGTVVAPLAITAMPDAVVWLPLNSAGSAVHDQLGVEPGAVVRIDRGRP
>NZ_AP022603.1|WP_085097794.1|1791446_1792766_+|NADH-quinone-oxidoreductase-subunit-NuoF
MNSPARTPLTPVLSRFWDAEQSWTLETYQRHHGYRALRKALAMKPDEVITMLKDSGLRGRGGAGFPTGTKWSFIPQDNPKPHYLVINADESEPGTCKDMPLLMSAPHFLVEGAIIAAYAIRARHAFVYVRGEVVPVLRRLRAAVEEAYAAGYLGTNIGGTGFDLDLVVHAGAGAYICGEETALLDSLEGRRGQPRLRPPFPAVAGLYACPTVVNNVESIASVPPVVLGGPDWFRSMGTEKSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGGVRAGHELKFWTPGGSSTPLLTAEHLDVPLDYEGMAGAGSMLGTKALQIFDETTCVVRAVRRWSDFYGHESCGKCTPCREGTYWLPQIYARLESGRGVPEDLDKLADIADTVFGKSFCALGDGAATPVLSSLQHFRAEYEAHLGAGCPFEPAAAMLAPPQGVIA
>NZ_AP022603.1|WP_085097796.1|1790727_1791450_+|NADH-quinone-oxidoreductase-subunit-NuoE
MSIDLPLGSRPEEPISPIGGPRRYPAEVTARLADDAATIIARYPQARSALLPLLHLVQSQDSYLTQAGIDFCAAQLGLTHAEVTAVATFYTMYRRSPTGRYLVGVCTNTLCAIMGGDAILATLQDHLGIPAGETTDDGTITLEHIECNAACDYAPVVMVNWEFFDNQTPSSATALADELRAGNTVVPTRGAALCPFSQTSRTLAGLPDPRPDTGPASAGEATLAGLRVARANGMTTPEAP
>NZ_AP022603.1|WP_085097798.1|1789435_1790731_+|NADH-quinone-oxidoreductase-subunit-D
MTDTVITLGGQDWDEVLAAARADDPGSERIVVNMGPQHPSTHGVLRLILEIDGETVTQARCGIGYLHTGIEKNLEYRNWTQGVTFVTRMDYLSPLFNETVYCLGVEKLLGITDDIPERATVIRVALMELNRISSHLVALATGGMELGAMSAMFYGFREREEILNVFEAITGLRMNHAYIRPGGLAADLPDDGVAGIRHLLDILPARLLDLDKLLRENTIWKARTRDVGYLDLAGCMALGVSGPVLRSTGLPHDLRRAQPYCGYQDYEFDVITGDNSDCYDRFLIRVDEMYQSLRIVRQCLDRLEPGPVMIADRKLAWPADLELGPDGLGNSPAHIARIMGTSMEGLIHHFKLVTEGIRVPAGQCYVAVESPRGELGVHMVSDGGTRPYRVHYRDPSFTNLQAVAAMSEGAMVADLIASVASIDPVMGGVDR
>NZ_AP022603.1|WP_085097801.1|1788755_1789439_+|NADH-quinone-oxidoreductase-subunit-C
MSDETPGPDQGPDVIAVRRGMFGAAGTGDTSGYGRLQQPVTLPGGSERPYGGYFDAVVDRLAEVLGDQFPHSVERVVVHRDQLTLQIARFRLPTVARALRDDPQLRFEFCAGVSGVHYPGDTDRELRAHYPLMSITHNRRIQLEVACPDTDPHVPSLFSVYPTTDWHERETYDFFGIIFDGHPGLTRIEMPDDWEGHPQRKDYPLGGIPVEYHGATIPPPDQRRAYS
>NZ_AP022603.1|WP_085097805.1|1788204_1788759_+|NADH-quinone-oxidoreductase-subunit-B
MGLEEALPGGILLTTVEKIAGFVRKGSLWPATFGLACCAIEMMATAGPRFDIARFGMERFSATPRQADLMIVAGRVSQKMAPVLRQVYDQMVEPKWVLAMGVCASSGGMFNNYAIVQGVDHIVPVDIYLPGCPPRPEMLLNAILMLHAKIAEMPLGVHREQVVAAAEAAALASPTTLELKGLLR
>NZ_AP022603.1|WP_085097808.1|1787851_1788214_+|NADH-quinone-oxidoreductase-subunit-A
MDLYTPILILGVIAALFAVGSVGIAVLIGPRRYNRAKLEAYECGIEPTQSLEHPGQRFPIKYYLTAMLFIVFDIEIVFLYPWAVTFDRLGLFALIEMVLFVAAVFVAYAYVWRRGGLEWD
>NZ_AP022603.1|WP_085097811.1|1786795_1787236_+|nitroreductase-family-deazaflavin-dependent-oxidoreductase
MTNASDFSSAQEQDFNRRNIAEFQANGGKVGGPFDGVDLLLLHTVGAKSGQPRLHPLAYFDIDGARYIVGSAAGRDADPAWVANVRANPEVRIEVGGAAPAAARVRKLPDAERNPVFAEIARRSSAFAAYQDATDRVIPVFEVLPA
>NZ_AP022603.1|WP_085097891.1|1786382_1786799_+|response-regulator-transcription-factor
MIGRVPTPLRVLVYSDNARTREQVLLALGKRVHPDLPELDHLEVATAPVVIREMDAGGVDLAILDGEAAPAGGMGIAKQLKDEIVDCPPILVLTGRRDDAWLAKWSRAEAAVPHPIDPIVLASTVTELLRPTTRKDPP
>NZ_AP022603.1|WP_085097814.1|1785649_1786267_-|LpqN/LpqT-family-lipoprotein
MGRFSRRAAAALLCGGLLLAGCSAGPKDVDNATEPAPAAEAAADGCAYTDAPLLTLPPRGPGEPTLELPQPRGWERNTTMDSETVRGVIVNTGMRADDFTPNAVVTLVDMTAKSPTPQQVIDIELAELSSNGVAVETADTMLVCGHPAMTVGYTLESRPVNAVIVGVAHEGKTFSAVVTMQTADPTNADYVADMDTILSGFRVSY
>NZ_AP022603.1|WP_085097782.1|1796938_1797670_+|NADH-quinone-oxidoreductase-subunit-J
MTGEQVAFWVLGAIAVAGALGVVAARKAVYSALFLATTMISLAVLYVAQGALFLGVVQVVVYTGAVMMLFLFVLMLIGVDSAESLTETIRGQRLAAIAAGLAFGVLVIAGIGAAATAGSAAKPAPTLAGPAAEIAAHGNVEGLAVLIFNRYLWAFEVTSALLITAALGAMVLAHRERLTARKTQRELAIERFGPGGHPTPLPNPGVFARSNGVDVAALLPDGSPAVLSVSATLTPRRGERDAT
>NZ_AP022603.1|WP_085097779.1|1797666_1797966_+|NADH-quinone-oxidoreductase-subunit-NuoK
MNPDHYLYLSALLFSIGAAGVLLRRSAIVVFMCVELMLNAANLAFVTFARVHGQLDGQVVAFFTMVVAACEVVIGLAIIMAIYRVRRSADVDDAHLLAK
>NZ_AP022603.1|WP_085097776.1|1798004_1800344_+|cbb3-type-cytochrome-c-oxidase-subunit-I
MAFDTKSQPPAGPEGDDEPTIGKGWVQGVALVMIFGFFVMGILAYRTYTASMPLPDKVVSQSGETVFTGAQVTRGQELFQARGLMQYGSIHGHGAYLGPDYTADYLRRAAESVTEQLQQAGNPQVHDAVVEQFRTNRYDEATKTLVYTDEQIKAFDALQKYYANYFGPESSKIGLLPNFITDPEQIHDLTAFFSWSAWAAAAERPGHNYTYTNNWPAEPLVDNGPTADLVVWSALSLVALLGGTGIMFAVYGRWSQKIGWHSNEAPVVSYRQPDEVVLTPSQRACVWFFVVISVLFFAQAMLGSLAEHYRADLSSFFGFDLAQWLPYNLARTWHLQLSLFWTAAAFLAAGIFLTPFITRKEPKKQHWLAYILLGAVALVVVGSLVSEALSVFGVISEGTLFSQQWEYLDLPRVWQILLTLGMFIWIAIVYRGLRARLKSTSMTGMPWLFFFSGLAIPAFYAVGLLAGSDVHFSVADFWRFWVVHLWVEDFLELFTTVMVAYIFVLLGVVRKRIAIGIIFLDIILYSAGGIIGTMHHLYFSGTPVEHMALGAFFSAAEVIPLTLLTVEAWTFLHLGSRQQSGDTKPFPHRWSVMFLVAVGFWNFLGAGVFGFLINLPIVSYYQIGTALTANHGHAAMMGVYGMLAVGLALFCFRYAIPENKWPEKAAKCSFWCLNIGLAWMVFATLLPLGVLQLYHSVNSGYFEARSLGYVTNPGNALLEWMRMPGDLIFILGGIVPLMYIGWVAARNFFGAPTTDELPEDTLYEELSAGTEEPETAARP
>NZ_AP022603.1|WP_085097773.1|1800340_1800970_+|hypothetical-protein
MTGPDIAVWLVSGYALLLVAIAWGFDLMAKRASSHAARWQSGSFAYHPDHDAWRCPEDQWLWPTSFDPENRVMRYRAKPSICNSCPVKKSCTTGSNGREISRQVDEWPHSEAGRFHRGIACVIAGLGMLLVVGQGVAKHSPADLLVLAAALLIVAACTAPLFRHLIHTPVQAPEHLPSRTAHEDSVAAAIDKYSTRWGVRQSEKESETR
>NZ_AP022603.1|WP_085097770.1|1800966_1801740_+|slipin-family-protein
MTWLLPAGVVLVVLVLLLWRSVNVLREYERGVVFRAGHLRPVCGPGLVFLFPLLDRIERVDLRVVTLTIPPQEVITKDNVPARVNAVVMFRVVDPSRAIMAVENYSVATSQIAQTTLRSLLGRADLDTLLAHREDLNTDLRGIIEKMTVDWGVEVGVVEIKDVEIPESMQRAMAREAEAERERRAKVINARGELQASEELRQASEELSKSPASLQLRYLQTLLELGADQNSTVVFPLPVDIITPFLNAARNRTSEGR
>NZ_AP022603.1|WP_085097767.1|1801741_1803613_+|NADH-quinone-oxidoreductase-subunit-L
MTLLWLPIALPLGGAIVLLLGGRRTDRWGHLLGCATVLGAFAVAVAGFAELLGRAAAHRVLQGNLFTWVPVGELRVDFGLRLDALSVCFVLLITGVGALIHLYSIGYLADDPGRRRFFGCLNLFVAAMLLLVLADNYLGLYLGWEGVGLASYLLIGFWQHKPSAAAAAKKAFVVNRVGDMGLMLAIAWMFAAAGTVSFAGVFAAAPLLTDTTLTGIGLLLLLGACAKSAQVPLQSWLGDAMEGPTPVSALIHAATMVTAGVYLIVRSGPVFNLAPAAQTAVVTVGAVTLLFGAIIGCAKDDIKKALAASTMSQIGYMVLAAGLGPAGYAVAIMHLLTHGFFKAGLFLGAGSVMHAMNDETDIRRLGGLRTVLPITYLTFGLGYLAIIGVPPFAGFFSKDAIIETAFAVGGLRGLLLGGAALIGAGITAFYMTRVMLLTFFGRPRWAPQAHPHESPRVMTVPMLLLAVGSVGAGAALAGGRLSGWLAPVVGSQHGEPQLPALAMTIITLAVVGAGIWAGYRMYAGEVADTAPTEVSALTIAARRDLYGDAVNEAVFMRPGRALSAGLVTLDDRVVDGAGRGLAAVVSGTSVLLRRGQTGYVRSYALFMLAGSAVLLAVIWAAGR
>NZ_AP022603.1|WP_085097764.1|1803609_1805184_+|NADH-quinone-oxidoreductase-subunit-M
MTGVPWLTLLWATPLLGAVLIIGMPAAARQLVRWAALGVSLLVLAIAVVLAAGFDPAGAQYQFVEDQPWIPSFGTGYLLGVDGIALALVVLTAVLVPLLIIAGWHDAPEGDELGGRGPHAYVALMLAVESMVLIALVSLDILLFYVFFEAMLIPLYFLIGGFGGFGERARRSAAAVKFLLYNLLGGLVMLAAVIALYVVTAGSDAFDAGTFDLRAIVAVVASGGLDVNPAVMHAIFLGFLFAFAIKAPLWPLHRWLPDAAVESTPATAVLMMAVVDKVGTFGMLRYCLQLFPDSAMLFRPLVITLAVIGIVYGAVVAIGQRDMMRLIAYTSISHFGFIVLGIFVMTSQGQAGSALYMVNHGLSTAALFLIAGFLVSRRGSRLIADYGGVQRVAPVLAGTFLVAGMATLSLPGLAPFISEFLVLVGTFTRYPVPAAIASTALVLSAVYILWLYQRVMGGPVRKGSDRLGDLRGRELVVVAPLLALLLVLGIYPKPALDVIDPAVQHTLSIVGEHDPAPQSARGPR
>NZ_AP022603.1|WP_085097761.1|1805180_1806794_+|NADH-quinone-oxidoreductase-subunit-NuoN
MTLDLLAAQSLPAPSVAYRLLAPMLIVFGAAIAGVLVEAFAPRRARFAAQLTLALGSLLAAMISVLVVGRGGAPDHTVMGGSVALDAPALFLQELILVIGLLGVLLIGERVIRIPSDSAAPADPDEAAADGLDGFTPQASTVPGSVAERQASAAGVMQTEVFPLTLLAIGGMLLFVAADDLLTLFVALEVLSLPLYVLCGLARRKRLLSQEAALKYFLLGAFSSAILLYGVALLYGFAGTLSLPGIAAAVAGGEVSTMALLGTGLLLVGLLFKVGAVPFGSWVPDVYQGAPTPITAFMAAATKIAAFGALLRVCYVMAPGLADAWRPVLWVVAILTMVVSTIAAVTQNDVKRLLAYSAVSHTGFILTGVIALNDAGIAATLFYLFAYGFSTLGSFAVVGLVRDADGQEATALSRWAGLGRRYPVLGVVFSLFLLAFAGIPLTSGFVAKFAVFKAAAEGGAMPLVVVGVLASAVAAYFYVRVIVLMFFTDPPENAPVLVRPSWTTSATVALTGGVTFALGVLPQPLLDLADAAVAFLR
>NZ_AP022603.1|WP_085097887.1|1807037_1808180_-|amidohydrolase
MTTTANERKPAAERIAVRCVDSDVHPMPKRGQLVEYLPEPWRSKYWGSHPYGELIYYDAPDYAHSYAMRVDSFPADGEFACSDPDLAFKQLIMEAGSDIAILEPGAYPARLPEADHAMSQALNSWQANHWLDSHNNWHERWRGSICVSIEAPQLAAAEIEKWAGHPYMAQILIKAERRPSWGDPCYDPVWAAATKHDIVVSCHLSRSHHEELPIPPVGFPSYNHDFMCSYSLLAANQVMSLIFDGVFDRFPTLRIVFVEHAFTWILPLMWRMDALYEARKSWMDIKRKPSEYVKEHIKFTTQPLDYPEDKTELMRAFEWMECEKLLLFSSDYPHWTFDDPRWLVKHLPEHAREAVMFRNGIQTYHLPDTVPALEGQVRVH
>NZ_AP022603.1|WP_085097758.1|1808364_1809630_+|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha
MPRFPKPAEGSWTEHYPQLGTGPVSYEDSINPDIYQLERAAIFKRAWLNVGRVELLPRKGSYFTKELKAVNTSIIVVRTKTGEVKAFHNICRHRGNKLVWNDMPAEETSGVCRQFTCKYHAWRFDLDGNLTFVQQEGEFFDLDKSKYGLVPVHCELWEGFIFVNFAAEPEQSLRDFLGPMITNLEGYPFDRLTQRFTYRAEVNANWKLYMDAFQEFYHAPILHANQSPTAYSKAAAEAGFEAPHYRIEGPHRLVSTSGVRVWEMSADMRKPIEDICRSGLFGPWEGPDLGPMPDGLNPANCEPWGLDSFQLFPNFVILFWGQGWYLTYHYWPTSHRTHIFECTLYFPQPRTPRERVAQELAAQSFKEYGLQDANTLEATQSSLETRVVGEFLYCDQEVLLRHLHNETANWIADYQRKTAGV

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Crispr_ID: NZ_AP022603_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022603_9

1819967-1820064

Orphan

Consensus_repeat	Method
GGTGTACGCAGCTGAGCGCTGGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022603_9

>merge|NZ_AP022603|9|1819967-1820064|CRISPRCasFinder
GGTGTACGCAGCTGAGCGCTGGCGCCACCCCGTCGCTGCCAGCGCTCAACCAGGTACACGACGCGCCGAGGAAAGGTGTACACAGCTGAGCGCTGGCG

>NZ_AP022603|9|7|1819967-1820064|CRISPRCasFinder
GGTGTACGCAGCTGAGCGCTGGCG	CCACCCCGTCGCTGCCAGCGCTCAACCAGGTACACGACGCGCCGAGGAAA
GGTGTACACAGCTGAGCGCTGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022603.1\|WP_085097714.1\|1823096_1824071_+\|NADPH:quinone-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|176203
NZ_AP022603.1\|WP_085097740.1\|1812910_1814170_+\|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl\|CDD\|376400
NZ_AP022603.1\|WP_085097743.1\|1812121_1812868_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235546
NZ_AP022603.1\|WP_109750558.1\|1820902_1821940_+\|phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|270703
NZ_AP022603.1\|WP_085097750.1\|1811258_1811705_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_AP022603.1\|WP_133055159.1\|1827815_1828574_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085097737.1\|1814169_1814502_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085097723.1\|1820142_1820745_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379883
NZ_AP022603.1\|WP_085097711.1\|1824075_1825455_+\|flavin-monoamine-oxidase-family-protein	unknown	unknown	gnl\|CDD\|224152
NZ_AP022603.1\|WP_085097732.1\|1815379_1816240_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187611
NZ_AP022603.1\|WP_085097884.1\|1816271_1817684_-\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143457
NZ_AP022603.1\|WP_085097717.1\|1821939_1823052_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085097705.1\|1826469_1826820_-\|Fe-S-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_133055160.1\|1826885_1827749_+\|carbon-nitrogen-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|143600
NZ_AP022603.1\|WP_085097696.1\|1828646_1830041_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|224157
NZ_AP022603.1\|WP_085097726.1\|1818631_1819783_-\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176223
NZ_AP022603.1\|WP_085097746.1\|1811823_1812129_+\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|131215
NZ_AP022603.1\|WP_085097729.1\|1817804_1818635_+\|thioesterase-family-protein	unknown	unknown	gnl\|CDD\|379298
NZ_AP022603.1\|WP_085097708.1\|1825456_1826365_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_AP022603.1\|WP_085097735.1\|1814533_1815379_+\|TauD/TfdA-family-dioxygenase	unknown	unknown	gnl\|CDD\|367137

Protein	Function_ID	Function_description	E-value
NZ_AP022603.1\|WP_085097740.1\|1812910_1814170_+\|Rieske-2Fe-2S-domain-containing-protein	gnl\|CDD\|376400	pfam00848, Ring_hydroxyl_A, Ring hydroxylating alpha subunit (catalytic domain). This family is the catalytic domain of aromatic-ring- hydroxylating dioxygenase systems. The active site contains a non-heme ferrous ion coordinated by three ligands.	8.64352e-47
NZ_AP022603.1\|WP_085097735.1\|1814533_1815379_+\|TauD/TfdA-family-dioxygenase	gnl\|CDD\|367137	pfam02668, TauD, Taurine catabolism dioxygenase TauD, TfdA family. This family consists of taurine catabolism dioxygenases of the TauD, TfdA family. TauD from E. coli is a alpha-ketoglutarate-dependent taurine dioxygenase. This enzyme catalyzes the oxygenolytic release of sulfite from taurine. TfdA from Burkholderia sp. is a 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase. TfdA from Alcaligenes eutrophus JMP134 is a 2,4-dichlorophenoxyacetate monooxygenase. Also included are gamma-Butyrobetaine hydroxylase enzymes EC:1.14.11.1.	7.43113e-57
NZ_AP022603.1\|WP_109750558.1\|1820902_1821940_+\|phosphotransferase-family-protein	gnl\|CDD\|270703	cd05154, ACAD10_11_N-like, N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins. This subfamily is composed of the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes. The ACAD10/11-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	8.84559e-66
NZ_AP022603.1\|WP_085097750.1\|1811258_1811705_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.06819e-17
NZ_AP022603.1\|WP_085097743.1\|1812121_1812868_+\|SDR-family-oxidoreductase	gnl\|CDD\|235546	PRK05653, fabG, 3-oxoacyl-ACP reductase FabG.	1.07058e-84
NZ_AP022603.1\|WP_085097723.1\|1820142_1820745_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	1.40133e-14
NZ_AP022603.1\|WP_085097732.1\|1815379_1816240_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187611	cd05353, hydroxyacyl-CoA-like_DH_SDR_c-like, (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs. Beta oxidation of fatty acids in eukaryotes occurs by a four-reaction cycle, that may take place in mitochondria or in peroxisomes. (3R)-hydroxyacyl-CoA dehydrogenase is part of rat peroxisomal multifunctional MFE-2, it is a member of the NAD-dependent SDRs, but contains an additional small C-terminal domain that completes the active site pocket and participates in dimerization. The atypical, additional C-terminal extension allows for more extensive dimerization contact than other SDRs. MFE-2 catalyzes the second and third reactions of the peroxisomal beta oxidation cycle. Proteins in this subgroup have a typical catalytic triad, but have a His in place of the usual upstream Asn. This subgroup also contains members identified as 17-beta-hydroxysteroid dehydrogenases, including human peroxisomal 17-beta-hydroxysteroid dehydrogenase type 4 (17beta-HSD type 4, aka MFE-2, encoded by HSD17B4 gene) which is involved in fatty acid beta-oxidation and steroid metabolism. This subgroup also includes two SDR domains of the Neurospora crassa and Saccharomyces cerevisiae multifunctional beta-oxidation protein (MFP, aka Fox2). SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	6.2626e-117
NZ_AP022603.1\|WP_085097884.1\|1816271_1817684_-\|aldehyde-dehydrogenase	gnl\|CDD\|143457	cd07139, ALDH_AldA-Rv0768, Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like. The Mycobacterium tuberculosis NAD+-dependent, aldehyde dehydrogenase PDB structure, 3B4W, and the Mycobacterium tuberculosis H37Rv aldehyde dehydrogenase AldA (locus Rv0768) sequence, as well as the Rhodococcus rhodochrous ALDH involved in haloalkane catabolism, and other similar sequences, are included in this CD.	0
NZ_AP022603.1\|WP_085097711.1\|1824075_1825455_+\|flavin-monoamine-oxidase-family-protein	gnl\|CDD\|224152	COG1231, COG1231, Monoamine oxidase [Amino acid transport and metabolism].	5.35279e-107
NZ_AP022603.1\|WP_133055160.1\|1826885_1827749_+\|carbon-nitrogen-hydrolase-family-protein	gnl\|CDD\|143600	cd07576, R-amidase_like, Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases). Pseudomonas sp. MCI3434 R-amidase hydrolyzes (R,S)-piperazine-2-tert-butylcarboxamide to form (R)-piperazine-2-carboxylic acid. It does so with strict R-stereoselectively. Its preferred substrates are carboxamide compounds which have the amino or imino group connected to their beta- or gamma-carbon. This subgroup belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), class 13 represents proteins that at the time were difficult to place in a distinct similarity group. It has been suggested that this subgroup represents a new class. Members of the nitrilase superfamily generally form homomeric complexes, the basic building block of which is a homodimer. Native R-amidase however appears to be a monomer.	8.3479e-88
NZ_AP022603.1\|WP_085097696.1\|1828646_1830041_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|224157	COG1236, YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis].	1.38219e-111
NZ_AP022603.1\|WP_085097726.1\|1818631_1819783_-\|zinc-binding-dehydrogenase	gnl\|CDD\|176223	cd08262, Zn_ADH8, Alcohol dehydrogenases of the MDR family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	5.26052e-135
NZ_AP022603.1\|WP_085097714.1\|1823096_1824071_+\|NADPH:quinone-oxidoreductase-family-protein	gnl\|CDD\|176203	cd08241, QOR1, Quinone oxidoreductase (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	7.33739e-130
NZ_AP022603.1\|WP_085097729.1\|1817804_1818635_+\|thioesterase-family-protein	gnl\|CDD\|379298	pfam13622, 4HBT_3, Thioesterase-like superfamily. This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.	4.97211e-22
NZ_AP022603.1\|WP_085097708.1\|1825456_1826365_-\|alpha/beta-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	8.82955e-26
NZ_AP022603.1\|WP_085097746.1\|1811823_1812129_+\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	gnl\|CDD\|131215	TIGR02160, 12-phenylacetyl-CoA_epoxidase_subunit_E, phenylacetate-CoA oxygenase/reductase, PaaK subunit. Phenylacetate-CoA oxygenase is comprised of a five gene complex responsible for the hydroxylation of phenylacetate-CoA (PA-CoA) as the second catabolic step in phenylacetic acid (PA) degradation. Although the exact function of this enzyme has not been determined, it has been shown to be required for phenylacetic acid degradation and has been proposed to function in a multicomponent oxygenase acting on phenylacetate-CoA. [Energy metabolism, Other].	8.6685e-18

>NZ_AP022603.1|WP_085097726.1|1818631_1819783_-|zinc-binding-dehydrogenase
MRAVSCLQGELSVVDLPNPRPEYGQLLLAVRRCGICGSDLHARVHADELHETLRLGGYDGAMSADTATVLGHEFIGEVLETGAGVRGFRPGTLVAAMPIRRVGGEGQMVGFSPHAPGGMAEQTVAETAFSFAVPNGLDLDTAAMTEPMAVALHAVHRSDIGRGDTAVVIGCGPVGLGIICQLKTKGVKKIVAADFSPTRRGLAARLGAHVVVDPSEDSVYNHLGAGFVTSPQQLWDFGIDTLDKLRRVPAWEHLYRVGDKFGAADPKRPIIFECVGVPGMIESIVAAAPLNTRVVVAGVCMEADRFQPALAIGKEIDLRFSFGYTPLEFRDTLHLLADGKLDVAPLITGQVGLDGVAAAFAALADPEGHAKILIDPASDATAP
>NZ_AP022603.1|WP_085097729.1|1817804_1818635_+|thioesterase-family-protein
MDLSPDAAVAEPALTPFFHRDGDSYVPNPIAQGGWGPTLGGQVIGGMLARAVEQQIEDPELIPVRLTVDILRRVATEPVQVSAEVLRAGKRMRALTATMTQRGEVVARASTLHLRPSVQPPDAAWTTPVSMPPLPTEPERFNPAVPMFITAYGKDDGDGFAWQHDGPRHAWLREVRELVAGEPMSPFVRAALAVDVTASMTNFTPSGLGFINADYTLTLCRLPEGPYIGLAALTHYSADGIAVGSATLFDTRGPIGTGLTTSAANPNFAGVPGERP
>NZ_AP022603.1|WP_085097884.1|1816271_1817684_-|aldehyde-dehydrogenase
MTQGSTERITVVSPHTEQPIATIDAASGADVDAAVAAARHAFDHGPWPRLDPAQRIAVVGRLTEIYAARGAEMAELITAEIGAPSTFSRRAQVGLPTAMMGALATLAADYPWQEERAGFFGGTVRIRREPVGVVAAIIPWNMPQLLIVTKLIPALLTGCTVILKPAPESPLDALLLAEMLDELDLPPGVVQVLPGGAEVGAQLVGHPGVDKVSFTGSTAAGRAVAAACAANLTKVSLELGGKSAAIVLDDADPATVATGVRVASLANSGQVCNALSRILVPAGRAGEYVDALAAELAGLRVGDPADSKTQIGPLISRRQQDRVRGYINAGVEQGARLVVGGAELPDGIDRGWYVRPTLFAGADNAMTIAREEVFGPVLTVIEYRDETEALGIANDSPYGLAGSVWTEDIDRGLALAAGVRTGTFGVNQGYTMDPFAPFGGVKCSGYGRELGREGLDAYVDAKSIAVATPR
>NZ_AP022603.1|WP_085097732.1|1815379_1816240_-|SDR-family-NAD(P)-dependent-oxidoreductase
MTLTFNGRVAVVTGAGGGLGRCHALELARRGAHVVVNDVGAAVDGSAESASAAQAVVDEITAAGGSAVANTDSVATVEGGRGIIETAVDNFGRIDILVNNAGILRDAAFKNMTPEQVDPVIDVHLRGAFHTCMAAWPHMREQNYGRIVMTTSGSGLFGTFGQANYGAAKTGLVGLMNVLAIEGQRNNILVNALSPIAKTRMTENTMAELVKEAAPEQVTPVVVYLAHQDCDRTAHIYRVGGTKVSRVFFGVTPGIDVPGLTAEDLVANIDRVDDPAGFIIRGGPGT
>NZ_AP022603.1|WP_085097735.1|1814533_1815379_+|TauD/TfdA-family-dioxygenase
MSVLTINKLTDSVGAEVDGVDADRLACDEQLGAAILDALEDNGVLVFRGLNLDPQAQVEFCARLGAVDRSSDGHHPVSGIYPITLDKAKNASADYLRATFDWHIDGCTPLHDECPQKATVLSAVQVAARGGETEFANSYAAYDNLTGEQQRHYGTLRVVHSLEASQRRVWPDPPAEMLARWRSRPTHEHPLVWTHRSGRKSLVLGASADHVVGMDLQRGRALLEELLAHATAPARVYSHRWVVGDTVIWDNQGVLHRAAPYEPDSPREMLRTTVLGDEPIQ
>NZ_AP022603.1|WP_085097737.1|1814169_1814502_+|hypothetical-protein
MSTRLPSAFAELEPFAETWCLETETERWNQRLASTMPVLHEFYDAFFPRLEEAIEYCDKYPLEELPEDATNLLRMIYSLIMVAMAVEVMHQPAPVDAADAVMIRTGEPRP
>NZ_AP022603.1|WP_085097740.1|1812910_1814170_+|Rieske-2Fe-2S-domain-containing-protein
MATDWPKPAEGSWTEHYPDLGTGPISFRDSTSPEFYALERAAIFKRAWLNLCRVEEIADPGDFLTKPVEAADATVLLVRGDDGVLRAFHNACRHHGNPLAHSDHPRGPSGEISGNNPAFSCRRCGWVYALDGRLVHTPEPGVEAADYGLVPVHCDVWAGFVFVNFDARPRQTLREFLGPMVTALEGYPFDRLTERYDWVAHNNSNWKIFADAFQEYYHVPALHSQQVPPEVRVPNAGFTCGHFQIDGPHRLVCTAGTRRWLLPDAYMYPIERATRSGLVGPWHTPDLGGLPMAGLNPGGIEPWGISNFQIFPNIEILFYGGWYLLYRYWPTSHNTHRYEAHTFFHPARTVRERIEHEVAAVVLKEFALQDAGMLGGTQAALEYDVVEEFPLNDQEILVRHLHKATGDWVRAYQDERGVA
>NZ_AP022603.1|WP_085097743.1|1812121_1812868_+|SDR-family-oxidoreductase
MTSRVAVVTGGASGMGEATCHELGRRGHRVAVADINAEAAERVAGALRADGVEAIAMPVDVSDRAGVEQAFTQVRERLGPVGILVTSAGLFGYASFADITVADWQRLVEVNLTGTFHCCQVALPDMVDAGWGRIVMISSSSAQRGTPFAAHYAASKGALLTLTKSLAREYAAVGITVNNIPPSGIETPMQHASQAAGFLPSDEQIASHIPVGHLGKPDDIAAAVGFLCSPEAGFITGQTLGVNGGAVM
>NZ_AP022603.1|WP_085097746.1|1811823_1812129_+|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein
MTPPTATASGTTTTVTIRLDRQTTTVGYRAGNTLLQTARLAGLHAPSSCEVGNCGTCIAQLTCGSARMLNNEVLDDDEIADGWVVTCQAIPTSPTVTVHYD
>NZ_AP022603.1|WP_085097750.1|1811258_1811705_+|MarR-family-transcriptional-regulator
MELTDNLLWLLKQAFHFSLTTVNEAVKPHGVSTAHLGVLRQLTQEPGLSGAELARRLLITPQGVQLALTGLEQRGLVERRQDPGHGRILHAYLTDEGRRVAAAVFTDAVAAHHRVFGVLSAAEQEQLRDLLGRVIEQGTGHALQEDHI
>NZ_AP022603.1|WP_085097723.1|1820142_1820745_-|TetR/AcrR-family-transcriptional-regulator
MKADDDTVDKGPGAGRPRDPRIDAAILAATAELLVEIGYPNVTMAAIAERAGTTKTALYRRWPGKAELVHEAAFPAAPTALDERSGDIAADIHAMIAAARDIFTSPVVRAALPGLIADMAADTELNDRVMGRFTQVFSVVRQRIVEAVRSGEVNPAVDPDRLVELIGGGTLMRLLMQPQQPLGDDWVDQTAAIVVHGVQK
>NZ_AP022603.1|WP_109750558.1|1820902_1821940_+|phosphotransferase-family-protein
MPDGIRPEITVESGIDSNGMSSETLILTGRWTDGGVATEQKWVARVAPTESDVPVFASYRLDHQFEVMRLAGELTDVPVPRVRWLENTGEVLGAPFFLMDHVDGQVPPDVMPYTFGNNWFFDATPEQQRLLQDSSIEVIAKLHSIPDAAGTFDFIADADPPGDTPLRRHFGWLQNWHEFAAADLGRSALVDRALAWLEENFPDDVAAGDPVLVWGDSRIGNVLYRDFRPAAVLDWEMATVGPREFDVSWIIFAHLVFQELCAMANLPGMPDVLREEDVRATYRRLTGVEIGDLRWFHVYAAVVWCCVFMRTGARRVHFGEMEQPEDIDSLFYHKPLLEKLLEGDA
>NZ_AP022603.1|WP_085097717.1|1821939_1823052_+|hypothetical-protein
MLGPMDEFPIHQVPQPIAWPGYSDRNFYDRSYFNAHDRSGDIFVISGIGYYPNLGVKDAFLLVRRGDTQTAVHLSDAIDGNRLDQHVGNYRVEVSEPLQRLRIHLDNTEGIAADLTWNGLFPVVQEQRHVLRAGTRVTLDAQRFAQLGSWSGHLEIDGEMITVDPAVWIGSRDRSWGIRPVGEAEPAGRPADPPFEGMWWLYVPVAFENFSIVLIIQEEPNGFRSLNDCTRIYADGRIEQLGWPRVKIHYTSGTRIPTGATIEATDGNGAPVRLDVESKLPCPIHVGGGYGGDSDWIHGTWKGENFTERLSYDMTDPGIVARSGFGVIDHVGRAVCHDADGEHEGWGLFEHGALGRHDPSGFADWLTVAP
>NZ_AP022603.1|WP_085097714.1|1823096_1824071_+|NADPH:quinone-oxidoreductase-family-protein
MRAIQITRLDGPEAVELNEVPEPVAGPDSVIIDVHAAGVAYPDALLTRGRYQYTPTLPFTPGGEVAGVVRSAPDGTGLTAGDRVLGLSMIVDGMAETIALPPERVFALPDNISFEAGAGTLFNDLTVLFALRTRGRLMPEETVLVHGAAGGIGTSALRLARALGAGRTIAVVSGADKIDAATAAGADEVVLADGFRAAVTELTGGRGVDIVVDPVGGDRFTDSLRSLAPAGRLLVIGFTGGEIPTVRVNRLLLNNIDVVGVGWGAWALSHPGYLAEAWDQLSALLTSGAVTAPDPQVFELARAGEAIAALENRAARGKIVLKVR
>NZ_AP022603.1|WP_085097711.1|1824075_1825455_+|flavin-monoamine-oxidase-family-protein
MAEEVDVVIIGAGFAGLAAARQLARTGLDVLVLEGRDRVGGRSWTQATAGIPLDLGATFVGPGQDAVLELARELGVATTPTYCAGNNVIHWRGKLRSYRGTVPKLSPATLANLGWVRWQLARLTRDVPIDAPWKAPEARRLDAMSLRQWLVSVRAAPATHDLMAIAARVTWGAEPDDVSMLHVLRYVKAAGGLDRMLDVTGGAQQDRFPGGTQEIAEKMAAELGDRVRLSTLVDRIIRDERGVRVRCGQPEKPAGDDENCEVNARTAIIAIPPQHRAAIEFSPALPAEYQRLMRCWPQGRLSKAYAVYEYPFWRIDGRSGEGLSDTGPVFITFDVSPSPAGPGVLLGFVDPRNFDELEPGQRREAALAGFANLFGERARHPVAYVDHSWGGEEFAPGGPTAAVPTGSWTGVGPWLRKPLGPIFWAGTETADEWTGFLDGAVRSGYRAADEAASWLARPD
>NZ_AP022603.1|WP_085097708.1|1825456_1826365_-|alpha/beta-hydrolase
MAAHLLLPASRDVDVRAADGTHLHTRVFGPEDGYPIVLTHGFVCAMGIWREQIIDLSRDHKVIAFDHRGHGRSGVPGRGHYSLNHLAADLDAVLEATLAPGQRAVIAGHSMGGMAIGAWSERYPHRVPDRADGVALINSSTGDVLRQIKLLSAPERLAGGRAAIGRRVVRHLGAVPAPRAVHKPTNLLVSRLAVGDDAHPDVHAVMHHLATSTSRRGRAEYGRMLLETMDRKHIRLDALVVPTLVIGGQADRLLPIGATHRIAQSAPNVFGVVELPGGHSTILEHPAAVNGHLRALIAAAAG
>NZ_AP022603.1|WP_085097705.1|1826469_1826820_-|Fe-S-protein
MEVLRNVVVLLHVVGFAIIFGAWVAEAAARRFRITSVMNYGLALSFVTGFALAAPWGGAVLNYPKITVKLALLLVIGAVLGIGSARQKRNGEPAPPALFWTAGLATLAAAAVAVLW
>NZ_AP022603.1|WP_133055160.1|1826885_1827749_+|carbon-nitrogen-hydrolase-family-protein
MVDPAPTDTGRAPADEPAARPAVRIAVAQRVPPRYGDPPALRRLATAATDANGADLLLVPELYPAGFRLDTDELAELAESRESFAAHLGAVARTHRIAIVAGYPERGPDDTVYSSAIFVDADGTELAHYRKLHLFGDETAAFGRGHQVPPVCRWRGWGVGLALCYDIEFPELARLLADRGADLICVPAGNMVGYSEVPEVLVPARACENQVFVAYANYCNSDDEFDYDGHSVVASPYGSLLAEAGQDEPQVLMVDLDPGLQAAARAHNTHRNDRRHDVYRGPDPTIG
>NZ_AP022603.1|WP_133055159.1|1827815_1828574_+|hypothetical-protein
MGKATVARRAGAAAVAVAMIGAGAACSSGTSGGPEPSTSASTSQTAPAEPFTGFIEPVTGTAGTVSYTAELPQLRGGDAAVRDRFNAAMRAALDGYLTPTEDNTPMTVAPGILDEDDRSEVAHIGTGAVAGVLLLNIFVDHAAHPFNTVATAVIDARTAEPIMIRDLFTDEAAGLAKLVEGITADIADEDKLVGQSAPEPVAEQLANWLPDDDGLVVYIPVAHVLGDYYPATVDWNSLADVLVPGMREKLTR
>NZ_AP022603.1|WP_085097696.1|1828646_1830041_+|MBL-fold-metallo-hydrolase
MDSTAGRLGEPNLTLSSLGAASTVTGSKHLLEADGKRILVDCGLFQGLKNLRELNWKRLPIDAESIAAVILTHAHLDHTGYLPRLVRDGFRGPIFATAATGAVAEIILRDSAYLQEREADFLNRHHVTKHSPAQPLYDGQDAERTLELFATREFGREFTVPDGGPTVRFRRAGHILGAATVELCWHGRRIVFTGDLGRYDDPLMLDPEPVPAADYLVMESTYGDRVHERSDPADTLAGIVDETVARGGTIVVPAFAVGRAQTLLYYLWQLRRAGRLPSVPIYLDSPMAINASDLLGRYRDDHRLTPDVYQDMCAIATYTRDVEESKLLSADRAPKIIISASGMATGGRILHHLKAFASDRRNTIMLTGYQSPGTRGRAIADGTPQVKIFGDWVPIRAQVANLRMLSAHADADELIRWAGGFDTAPQRVFVVHGEPQAADALRSRLDREFGWSATVPRQNQVFNL

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Crispr_ID: NZ_AP022603_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022603_10

2065966-2066050

Orphan

Consensus_repeat	Method
CGCCCGCTGACGACCGAGGTCGACG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022603_10

>merge|NZ_AP022603|10|2065966-2066050|CRISPRCasFinder
CGCCCGCTGACGACCGAGGTCGACGAAGGAGACCGAGGGAGGAAGCGGGCGCGTCGATACCGCCCGCTGACGACCGAGGTCGACG

>NZ_AP022603|10|8|2065966-2066050|CRISPRCasFinder
CGCCCGCTGACGACCGAGGTCGACG	AAGGAGACCGAGGGAGGAAGCGGGCGCGTCGATAC
CGCCCGCTGACGACCGAGGTCGACG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022603.1\|WP_085095311.1\|2060485_2061814_-\|thymidine-phosphorylase	unknown	unknown	gnl\|CDD\|180276
NZ_AP022603.1\|WP_085095329.1\|2075281_2076406_+\|homoserine-O-acetyltransferase	unknown	unknown	gnl\|CDD\|234678
NZ_AP022603.1\|WP_085095315.1\|2063438_2065193_+\|succinate-dehydrogenase-flavoprotein-subunit	unknown	unknown	gnl\|CDD\|236185
NZ_AP022603.1\|WP_085095327.1\|2073970_2075272_+\|bifunctional-o-acetylhomoserine/o-acetylserine-sulfhydrylase	unknown	unknown	gnl\|CDD\|236105
NZ_AP022603.1\|WP_085095290.1\|2055344_2056514_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|349936
NZ_AP022603.1\|WP_085095294.1\|2057421_2058045_-\|uracil-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234653
NZ_AP022603.1\|WP_085095323.1\|2071899_2072778_-\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|197336
NZ_AP022603.1\|WP_163742669.1\|2056614_2057397_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|236183
NZ_AP022603.1\|WP_085095325.1\|2072857_2073697_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_AP022603.1\|WP_085095313.1\|2061870_2062281_-\|cytidine-deaminase	unknown	unknown	gnl\|CDD\|180142
NZ_AP022603.1\|WP_085095320.1\|2069508_2069826_+\|multidrug-efflux-SMR-transporter	unknown	unknown	gnl\|CDD\|224987
NZ_AP022603.1\|WP_085095318.1\|2067260_2068517_+\|D-alanyl-D-alanine-carboxypeptidase	unknown	unknown	gnl\|CDD\|224600
NZ_AP022603.1\|WP_085095314.1\|2062951_2063422_+\|succinate-dehydrogenase-hydrophobic-membrane-anchor-subunit	unknown	unknown	gnl\|CDD\|239580
NZ_AP022603.1\|WP_085095322.1\|2070892_2071903_-\|tryptophan--tRNA-ligase	unknown	unknown	gnl\|CDD\|234866
NZ_AP022603.1\|WP_085095307.1\|2058116_2059379_+\|primosomal-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085095421.1\|2062534_2062951_+\|succinate-dehydrogenase,-cytochrome-b556-subunit	unknown	unknown	gnl\|CDD\|239581
NZ_AP022603.1\|WP_085095309.1\|2059389_2060481_-\|adenosine-deaminase	unknown	unknown	gnl\|CDD\|236480
NZ_AP022603.1\|WP_085095321.1\|2069847_2070891_-\|inner-membrane-protein-YhjD	unknown	unknown	gnl\|CDD\|188082
NZ_AP022603.1\|WP_085095319.1\|2068529_2069399_-\|nitronate-monooxygenase	unknown	unknown	gnl\|CDD\|240081
NZ_AP022603.1\|WP_085095317.1\|2066054_2067077_-\|crotonase/enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl\|CDD\|236213

Protein	Function_ID	Function_description	E-value
NZ_AP022603.1\|WP_085095311.1\|2060485_2061814_-\|thymidine-phosphorylase	gnl\|CDD\|180276	PRK05820, deoA, thymidine phosphorylase; Reviewed.	0
NZ_AP022603.1\|WP_085095315.1\|2063438_2065193_+\|succinate-dehydrogenase-flavoprotein-subunit	gnl\|CDD\|236185	PRK08205, sdhA, succinate dehydrogenase flavoprotein subunit; Reviewed.	0
NZ_AP022603.1\|WP_085095327.1\|2073970_2075272_+\|bifunctional-o-acetylhomoserine/o-acetylserine-sulfhydrylase	gnl\|CDD\|236105	PRK07812, PRK07812, O-acetylhomoserine aminocarboxypropyltransferase; Validated.	0
NZ_AP022603.1\|WP_085095290.1\|2055344_2056514_-\|amidohydrolase	gnl\|CDD\|349936	cd08014, M20_Acy1-like, M20 Peptidase aminoacylase 1 subfamily. Peptidase M20 family, uncharacterized subfamily of uncharacterized bacterial proteins predicted as putative amidohydrolases. These are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. Aminoacylase 1 (ACY1) breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	0
NZ_AP022603.1\|WP_085095313.1\|2061870_2062281_-\|cytidine-deaminase	gnl\|CDD\|180142	PRK05578, PRK05578, cytidine deaminase; Validated.	4.07835e-71
NZ_AP022603.1\|WP_085095294.1\|2057421_2058045_-\|uracil-phosphoribosyltransferase	gnl\|CDD\|234653	PRK00129, upp, uracil phosphoribosyltransferase; Reviewed.	4.8334e-93
NZ_AP022603.1\|WP_085095323.1\|2071899_2072778_-\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|197336	cd10281, Nape_like_AP-endo, Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases. This subfamily includes Neisseria meningitides Nape and related proteins. These are Escherichia coli exonuclease III (ExoIII)-like AP endonucleases and belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiences. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity; for example, Neisseria meningitides Nape and NExo. Nape, found in this subfamily, is the dominant AP endonuclease. It exhibits strong AP endonuclease activity, and also exhibits 3'-5'exonuclease and 3'-deoxyribose phosphodiesterase activities.	7.81677e-112
NZ_AP022603.1\|WP_163742669.1\|2056614_2057397_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|236183	PRK08202, PRK08202, purine nucleoside phosphorylase; Provisional.	1.66329e-126
NZ_AP022603.1\|WP_085095325.1\|2072857_2073697_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	3.85567e-21
NZ_AP022603.1\|WP_085095318.1\|2067260_2068517_+\|D-alanyl-D-alanine-carboxypeptidase	gnl\|CDD\|224600	COG1686, DacC, D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane].	3.99846e-80
NZ_AP022603.1\|WP_085095320.1\|2069508_2069826_+\|multidrug-efflux-SMR-transporter	gnl\|CDD\|224987	COG2076, EmrE, Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism].	2.32106e-19
NZ_AP022603.1\|WP_085095319.1\|2068529_2069399_-\|nitronate-monooxygenase	gnl\|CDD\|240081	cd04730, NPD_like, 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase family that reduce a range of alternative electron acceptors. Most use FAD/FMN as a cofactor and NAD(P)H as electron donor. Some contain 4Fe-4S cluster to transfer electron from FAD to FMN.	1.59572e-57
NZ_AP022603.1\|WP_085095314.1\|2062951_2063422_+\|succinate-dehydrogenase-hydrophobic-membrane-anchor-subunit	gnl\|CDD\|239580	cd03500, SQR_TypeA_SdhD_like, Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential quinones such as menaquinone and thermoplasmaquinone. SQR is also called succinate dehydrogenase or Complex II, and is part of the citric acid cycle and the aerobic respiratory chain. SQR is composed of a flavoprotein catalytic subunit, an iron-sulfur protein and one or two hydrophobic transmembrane subunits. Members of this subfamily are similar to the Thermoplasma acidophilum SQR and are classified as Type A because they contain two transmembrane subunits as well as two heme groups. Although there are no structures available for this subfamily, the presence of two hemes has been proven spectroscopically for T. acidophilum. The two membrane anchor subunits are similar to the SdhD and SdhC subunits of bacterial SQRs, which contain heme and quinone binding sites. The two-electron oxidation of succinate in the flavoprotein active site is coupled to the two-electron reduction of quinone in the membrane anchor subunits via electron transport through FAD and three iron-sulfur centers. The reversible reduction of quinone is an essential feature of respiration, allowing transfer of electrons between respiratory complexes.	1.13862e-39
NZ_AP022603.1\|WP_085095322.1\|2070892_2071903_-\|tryptophan--tRNA-ligase	gnl\|CDD\|234866	PRK00927, PRK00927, tryptophanyl-tRNA synthetase; Reviewed.	0
NZ_AP022603.1\|WP_085095329.1\|2075281_2076406_+\|homoserine-O-acetyltransferase	gnl\|CDD\|234678	PRK00175, metX, homoserine O-acetyltransferase; Provisional.	0
NZ_AP022603.1\|WP_085095421.1\|2062534_2062951_+\|succinate-dehydrogenase,-cytochrome-b556-subunit	gnl\|CDD\|239581	cd03501, SQR_TypeA_SdhC_like, Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential quinones such as menaquinone and thermoplasmaquinone. SQR is also called succinate dehydrogenase or Complex II, and is part of the citric acid cycle and the aerobic respiratory chain. SQR is composed of a flavoprotein catalytic subunit, an iron-sulfur protein and one or two hydrophobic transmembrane subunits. Members of this subfamily are similar to the Thermoplasma acidophilum SQR and are classified as Type A because they contain two transmembrane subunits as well as two heme groups. Although there are no structures available for this subfamily, the presence of two hemes has been proven spectroscopically for T. acidophilum. The two membrane anchor subunits are similar to the SdhD and SdhC subunits of bacterial SQRs, which contain heme and quinone binding sites. The two-electron oxidation of succinate in the flavoprotein active site is coupled to the two-electron reduction of quinone in the membrane anchor subunits via electron transport through FAD and three iron-sulfur centers. The reversible reduction of quinone is an essential feature of respiration, allowing transfer of electrons between respiratory complexes.	3.09798e-43
NZ_AP022603.1\|WP_085095309.1\|2059389_2060481_-\|adenosine-deaminase	gnl\|CDD\|236480	PRK09358, PRK09358, adenosine deaminase; Provisional.	5.552e-148
NZ_AP022603.1\|WP_085095321.1\|2069847_2070891_-\|inner-membrane-protein-YhjD	gnl\|CDD\|188082	TIGR00766, Uncharacterized_protein_Dda3937_02003, inner membrane protein YhjD. This family, including YhjD in E. coli, is a conserved inner membrane protein homologous YihY, which in turn was incorrectly assigned to be ribonuclease BN. This, any suggestion this family is similar to ribonucleases should be removed. [Transcription, Degradation of RNA].	1.7593e-75
NZ_AP022603.1\|WP_085095317.1\|2066054_2067077_-\|crotonase/enoyl-CoA-hydratase-family-protein	gnl\|CDD\|236213	PRK08272, PRK08272, crotonase/enoyl-CoA hydratase family protein.	0

>NZ_AP022603.1|WP_085095315.1|2063438_2065193_+|succinate-dehydrogenase-flavoprotein-subunit
MIQEHRYDVVIVGAGGAGMRAAVEAGPRARTAVLTKLYPTRSHTGAAQGGMCAALANVEEDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFNEFYALDVTLTDTPSGPVATGVIAYELATGDIHIFHAKAIVFATGGSGRMYKTTSNAHTLTGDGLGIIFRKGLPLEDMEFHQFHPTGLAGLGILISEAVRGEGGRLLNADGERFMERYAPTIVDLAPRDIVARSMVIEVLEGRGAGPNKDYVYIDVRHLGADVLEAKLPDITEFARTYLGVDPVTELVPVYPTCHYVMGGIPTNVHGQVLRDNNNYVPGLYAAGECACVSVHGANRLGTNSLLDINVFGRRAGLAAAEYAASHDFVDLPPEPARMVVEWVGDILGEHGHERVADIRGALQQTMDNNAAVFRTEETLKQALTDIHALKERYGRITVHDKGKRFNSDLLEAIELGFLLELAEVTVAGALNRKESRGGHAREDYPNRDDTNYLRHTMAYKEGAELLSDIRLDYKPVVQTRYEPMERKY
>NZ_AP022603.1|WP_085095314.1|2062951_2063422_+|succinate-dehydrogenase-hydrophobic-membrane-anchor-subunit
MTAPWTPHHRDGRAAPVLEKEYDRPAALDHPRAPRRPRGVPYFEKYAWLFMRFSGVALVFLVIGHLFIMLMWSDGVYRIDFNYVAERWASPFWQIWDMSLLWLAMLHGANGMRTIIGDYTRKNTTKFYLNSLLLLATGFTVVLGSYVLVTFNPNIG
>NZ_AP022603.1|WP_085095421.1|2062534_2062951_+|succinate-dehydrogenase,-cytochrome-b556-subunit
MTAAAPAEPAKTGTRRRRSLYRGDPGMWSWVLHRITGATIFFFLFVHVLDTALVRVSPEAYNAVVGTYKTPLVGLMEVGLVAAVLFHALNGIRVILIDFWSEGPRHQKKMLIAVAAVWLVVMVPALVVLGMHMAERFL
>NZ_AP022603.1|WP_085095313.1|2061870_2062281_-|cytidine-deaminase
MPTESSIDWKLLRDSAIAVSARAYAPYSGFPVGAAALVDDGRVLTGCNVENVSYGLGLCAECAVVCALFAGGGGRLRALACVDADGRALMPCGRCRQLLHEHGGPDLLVDTGAGPRRLAELLPDAFGPEDLDRVRR
>NZ_AP022603.1|WP_085095311.1|2060485_2061814_-|thymidine-phosphorylase
MSRRPSAEKTPPPFDAPTVIRMKRDGGRLPDAAIDWVIDAYTAGTVGDEQMAALLMAIFLRGMDAEEITRWTAAMINSGPRLDFADLRGPGGKPLTLVDKHSTGGVGDKITIPLVPIIVACGGAVPQASGRGLGHTGGTLDKLETIPGFSAELSVAQIRDQLAGIGAAIFAAGELVPADRKLYALRDITATVDSLPLIASSIMSKKLAEGTRSLVLDVKSGSGAFLQDPAEAARLASTMVGLGAAYGVPTRALLTDMSVPLGRMVGNAVEVVESVQVLAGGGPPDVLELTLALAAEMLDLAGLDGRDPADTLADGTAMDAYRALVRAQGGDPDAPLPTGACTETVIAPDSGVMGDIDALAVGRAVWRLGAGRTAPGDAVAAGAGIELHRRPGEPVAAGQPLFTLSADTAERLAPALAELDGAWSIGALPPPPRRLLLGRVEE
>NZ_AP022603.1|WP_085095309.1|2059389_2060481_-|adenosine-deaminase
MTTELDLGSIRHAPKVLLHDHLDGGLRPDTVLELAERAGYRELPADEPVALADWFRTAAHSGSLERYLQPFAHTVAVMQTAEALHRVAYECVRDLAADAVVYAEVRFAPELHLAAGLTLPQVVEAVLAGFAAGQQDAAAAGTPIVVRTLVTAMRHAARSLDIAELAIDYRDRGVCGFDIAGAEAGHPPTRHLDAFEHIREYNGHSTIHAGEAFGLPSIHEALAFCGADRLGHGVRIVDDITEAADGGQRLGRLAALVRDNRVPLELCPSSNVQTGAVPSFAEHPFDLLARLRFRVTVNTDNRLMSDTSMSREMLRLVETFGYGWADLQRFTINAMKSAFYPFDQRLALIDDVIKPRYAVLIGG
>NZ_AP022603.1|WP_085095307.1|2058116_2059379_+|primosomal-protein
MAADLVPIRLSVTAGDLFTIWAPPWRDAGDEWEAFLGNDEDLYGFDSVAELTAFVRSGAANDLNDHPAWAALTEANAHALDPDEEHRFDLVGVEELFAGKPTEESVSALAAILAVVSAIGSVCELPPVTKFFNGNPSLAMLNNGVLEFGGRVGRKRWAALAEIVGRNWEKVLGAIEEVLTSPEVDESAVDAAKEQLAADPPEPEEIEEILAVDEDTSDEDDDDQDETNDARAAGDTAVLGSDADFWGRVGIDPVRLMFGTGTLYSLRCYFGDRPLFLGRNGRISVFGSERALARYLADEHDHDLANLVTYDDIRTAANDGSLVVKVTDENVYVLTGLADDIADGPDAVDHQQLELAVELLRDVGDYSEDDTVDTALDPEQPFGGFVSRVLDDAEVEVSAQRAAEAYEALERFVESRLRRE
>NZ_AP022603.1|WP_085095294.1|2057421_2058045_-|uracil-phosphoribosyltransferase
MDIRVVDHPLAAVRLSTLRDRDTGDAAFRVALAELATMLVYEATRDLDRVGYPVATPLTETLGYRLATPPLLVPVLRAGLGMLAAAQALLPESRCGFIGVARDEHTHRADEYLVSLPEDLRGTPVLVLDPMLATGGSMVDALRRLAERGATNVTAVCVVCAPQGLAAAEAAMPGLRLITAVVDDGLNPDAFIVPGLGDAGDRQFGPR
>NZ_AP022603.1|WP_163742669.1|2056614_2057397_+|purine-nucleoside-phosphorylase
MRSAAAAAAVIAERTAVPEHDVAVVLGSGWAPAADALGAPDTVLAMAELPGFSAPTAAGHGGQLRSLRIGAHRVLVLLGRIHGYEGHPPADVVHPVRTACAAGAGTVVLTNAAGGLRPEYTVGQPVLIADHLNLTARSPLVGAQFVDLVDAYSPRLRAAARRVDPALAEGVYAGLPGPHYETPAEIRMLRTLGADLVGMSTVHETIAARAAGAEVLGMSLVTNLAAGMTGEPLSHAEVLAAGRRSAAAMGALLAATIAGL
>NZ_AP022603.1|WP_085095290.1|2055344_2056514_-|amidohydrolase
MSMTQIAEGWLARNVDDVVAWRRHIHAHPELGRREHATTAFVAEKLAAAGLSPRLLPGGTGLTCDIGPDFRPRIALRADMDALPMAEQTGRPFSSTVPGVAHACGHDAHTAMLLGAGLALAEVPDLPVGVRLVFQPAEELMPGGALDVIAADALAGVSRIFALHCDPRLAAGKVAITAGPITSAADWLTVTLSSPGGHTSRPHLTGDLVYALGTLITGVPGVLSRRIDPRDSTVMVWGAVNAGMAANAIPQSGTLSGTVRTASRTAWAQMEDLVREVVDCLLAPLNIEHTVQYTRGVPPVVNDEVSTRIFSHAIEDVGPDALADTRQSGGGEDFSWYLEKVPGAMARLGVWSGVGPQLDLHQPNFDIDERALAIGVRVLVNLVRQSAAF
>NZ_AP022603.1|WP_085095317.1|2066054_2067077_-|crotonase/enoyl-CoA-hydratase-family-protein
MQQHDHDGNRAAAWYENWTEAPDSPWRDRPEPADDRDYRTLTYRRTGRIARITFNRPEQGNAITADTPLDLAHAVETADLDPRVHVVLLSGRGKGFCGGYDLQIFAEGGAGGGGVGEHATAGSAIDPVVQASNHNPWRGWDPMLDYAMMSRFNKGFASLLHANKPTVAKIHGFAIAGGTDIALYCDQIICADDAMIGYPPTRVWGIPAAGMWAHRLGDQRAKRLLFTGDRISGRQAAEWGLAVESCPPESLDERAEDLVERIARMPVNQLMMAKLALNSALLAQGVANSTMISTVFDGVSRHTREGYAFQLRAATVGFREAVRERDEPYGDHKGKPGPTG
>NZ_AP022603.1|WP_085095318.1|2067260_2068517_+|D-alanyl-D-alanine-carboxypeptidase
MLTSRSPRTRLAALTAALFIAAAPAALTPATALADPEPPAPECPFRITTPPAVDASEVPKPGEPEPGPLAVPAKTVGGSDLAGCGIITAADTPPVPGDVSAEAWLVADLDSGEVIAARDPHGRHRPASVIKALTAMASINELNLNKPVAGTVEDARSEGTKVGVDVGGTYTVNDLLHGLLMHSGNDAAHALAGQLGGMPVALGKLNTMAALLGARDTRVATPSGLDGPGMSTSAYDIGLIYRYAWQNPTFAQIVATRTYNFPGHFTPETGDHPAYELENDNKLLVNYPGALGGKTGYTDDAGQTFVGAAERDGRRLVAVLLRGTRQPIAPWEQAARLLDYGFATAPGTAIGQLVDPDPALTRVEPEPTAAVNAATLIPAADATPVRVGVGVVGTLVVFSLIMVARSINRRSVGAGLAR
>NZ_AP022603.1|WP_085095319.1|2068529_2069399_-|nitronate-monooxygenase
MPIATPWSASLGLRHPVVNAPMGGAAGGRLAAAVSAAGGLGMIGMGSAASAEALTAELAELGAVRPFGIGLVHWVTEAAPGLLDTALAARPDLLCVSFGDEWSWVSRARAAGISTATQVASVPAALRAVDAGVQVLVARGAEGGGHGEPRVGTLPLLAEVLDAVEVPVLAAGGIATGRALAAVLAAGAAGAWLGTVLAASTEALTRPADRDLLLAAASTDTVNTSEFDLALGYSWPSWQPERVLVDADGAALPVNAGQGVGAVRAARPAAVVLDDLCGQAAGLLGRWAR
>NZ_AP022603.1|WP_085095320.1|2069508_2069826_+|multidrug-efflux-SMR-transporter
MAWLILVLSGALEAVWATALSRSDGLTRPIPTAIFGVSVVISMFGLGYAMRFLPPGTSYAVWVGIGAALTVLVAMITGTEAASLAKVALLTGLIGCVIGLQLVSQ
>NZ_AP022603.1|WP_085095321.1|2069847_2070891_-|inner-membrane-protein-YhjD
MTTTDARAELPETAARPGVLARLRARWRWFDHVWRAQQRYNDSKGDFYAAGITYYTIFSLFPLLMVAFAVGGFILVNHPELLDSIEGQIKGVVSGELGEQLIALMDSAIASRTSVGVIGLATAAWAGLGWMNNVREALTQMWGSQRTVKPTFIRGKLSDLGALASAGVALGLTIGLTALGSTSLLADLLRWAGVPDSPLTSAALRAASIVMSVLVGWALFTWMIARLPRESASLRSCLRAGLIAAVGFEAFKQVASIYLKSVLTGPAGATFGPVLGLMVFAYVTARLVLFATAWAATARENLAPEIVPPGPAVIRNRVITRPALGPAAAAAAAAGVGGWLLGRRRRR
>NZ_AP022603.1|WP_085095322.1|2070892_2071903_-|tryptophan--tRNA-ligase
MSAKQVVFSGAQPTSDSLHLGNALGAVKQWAAMQDDHDAYFCVVDLHAITVAQDPAELRRRTLTTAAQYLALGIDPARATVFVQSHVPAHAELAWVLGCFTGFGQASRMTQFKDKSVRHGADATTVGLFTYPVLMAADILLYDANLVPVGEDQRQHLELARDLAQRFNARFPGTFVVPDALIPKATAKIYDLADPSAKMSKSAATDAGLIALLDDPARIAKKIRSAVTDSEREIRFDPEHKPGISNLLTIQSAVTGTPVAELVAGYDGRGYGDLKKETAEVVVEYVTPIRARVTELLADPAELESILAAGAQRAGQVAERTVARAYDALGLLPRRS
>NZ_AP022603.1|WP_085095323.1|2071899_2072778_-|endonuclease/exonuclease/phosphatase-family-protein
MIVTTVNVNGIRAAVRERSTDNPGLLAWLKETRADVVCLQETRADDGQLTEALAPALADGWQLASALSERKGRNGVAVLSRVPITEVRAGCGHDEFADHGRYLEVDLDDGGQPLTVASIYVPTGEALTERQAEKERFLAATEARMAELAARAGSGGPDAVLCGDWNIAPAEADLKNWKGNLKKAGFLPEERAWVADRLSGGWVDVMRTLHPEVTGPYSWWSWRGQAFDNDAGWRIDYQLATAGLAGRAIAGGTERPGAYALRWSDHAPVTVEYAPRPADAAGPGQRDKIVGS
>NZ_AP022603.1|WP_085095325.1|2072857_2073697_+|alpha/beta-hydrolase
MRPVRDAIHLGSGEPVLLLHPFMMSQNVWKDVAPMLADTGRYEVYAPTMPGHNGGVKARMFLDTKELADDVERRMDELGWPTAHIVGNSLGGWVAFEMMRRGRARTLTAIAPAGGWRHFSPVKFEIVAKFLLGFPVWIIAKLLGAGRVLKFPFTRWFASVPISATPQALPEADLPAILDDVTHCAAYYQLLVKALLLPGLQELANADAPTNLVLCEKDRVLPHPRFARQFIRELPADTVVTRMDRVGHIPMFEDPARTAALITDFIEANRVPPAAEQPA
>NZ_AP022603.1|WP_085095327.1|2073970_2075272_+|bifunctional-o-acetylhomoserine/o-acetylserine-sulfhydrylase
MSTPTTADWSFETKQIHAGQQPDPATGARALPIYQTTSYVFNDTDHAAALFSLAEPGNIYTRIMNPTADVVEQRIAALEGGVAGLFLSSGQAATTLALLNVAGAGDHIVSSPRLYGGTYNLLHHTLRRLGIEISFVADPDDPQSWAAQVRENTRAFFGETISNPQGDIFDIPGVAEVAHADGIPLILDNTIATPYLIRPFEHGADVVVHSATKYLSGHGTAIAGVIVDGGTFDWTQGRHPGFTTGDDSYHGVVYADLGAPAFALKARVQLLRDLGSAGSPFNAFLVSQGLETLSLRVERHVANAARVAQFLADRDEVTAVHYAGLPSSPWHQRAQRLAPRGTGAVLAFELAGGLAAGKAFVDALTLHSHVANIGDVRSLVIHPASTTHQQLSEAEQRASGVTPGLVRLAVGIEGIDDILADLERGLAAAATAA
>NZ_AP022603.1|WP_085095329.1|2075281_2076406_+|homoserine-O-acetyltransferase
MTISEIPTTVALPAQGEVGIVDIGELKLENGALLDNVSIAVQRWGELSPTRDNAVIALHALTGDSHVIGPAGPGHPTPGWWDGMAGPGAAIDTDRWCLIATNVLGGCRGSTGPGSLARDGRPWGSRFPQLTIRDQVAADVAALAALGITEVAAVLGGSMGGARALEWALAHPESVRAALVLAVGARATADQIGTQSTQIAAIKTDPNWLGGDYHGTGRRPDAGLEVARRVAHLTYRGEVELDERFGNAAQGGEDPLTGGRYAVQSYLEHQGAKLVNRFDAGSYVALSDALSSHDVGRGRGGVAAALAACPVPTVVGGITSDRLYPLRLQQEIAELLPGCAGLDVIDSPSGHDGFLIEADAVAALLRRTLELAGQ

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Crispr_ID: NZ_AP022603_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022603_11

2535884-2535990

Orphan

Consensus_repeat	Method
CGGCCGGTTCGACGAGCGGTGTAGTTCCGCGAGTAAGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022603_11

>merge|NZ_AP022603|11|2535884-2535990|CRISPRCasFinder
CGGCCGGTTCGACGAGCGGTGTAGTTCCGCGAGTAAGAGACCGGCCGGCAACAACGCCGGCCGGTTCTCGGCCGGTTCGACGAGCGGTGTAGTTCCGCGAGGAAGAG

>NZ_AP022603|11|9|2535884-2535990|CRISPRCasFinder
CGGCCGGTTCGACGAGCGGTGTAGTTCCGCGAGTAAGAG	ACCGGCCGGCAACAACGCCGGCCGGTTCT
CGGCCGGTTCGACGAGCGGTGTAGTTCCGCGAGGAAGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022603.1\|WP_085097364.1\|2530446_2530890_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_AP022603.1\|WP_085097357.1\|2533347_2535120_-\|acyl-CoA-synthetase	unknown	unknown	gnl\|CDD\|236097
NZ_AP022603.1\|WP_085097347.1\|2539735_2540539_+\|mycofactocin-coupled-SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|274889
NZ_AP022603.1\|WP_085097433.1\|2536744_2538208_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143410
NZ_AP022603.1\|WP_085097333.1\|2544479_2545109_+\|allophanate-hydrolase-subunit-1	unknown	unknown	gnl\|CDD\|367142
NZ_AP022603.1\|WP_085097351.1\|2538908_2539739_+\|mycofactocin-coupled-SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|274889
NZ_AP022603.1\|WP_085097354.1\|2538221_2538827_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380056
NZ_AP022603.1\|WP_085097373.1\|2524249_2524483_+\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|376348
NZ_AP022603.1\|WP_085097370.1\|2524479_2528616_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|341253
NZ_AP022603.1\|WP_085097338.1\|2542764_2543769_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
NZ_AP022603.1\|WP_085097382.1\|2521290_2522160_+\|TauD/TfdA-family-dioxygenase	unknown	unknown	gnl\|CDD\|225086
NZ_AP022603.1\|WP_085097367.1\|2529787_2530234_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085097344.1\|2540535_2541330_+\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|131478
NZ_AP022603.1\|WP_085097360.1\|2531111_2533307_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173841
NZ_AP022603.1\|WP_109750544.1\|2522748_2524257_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|180293
NZ_AP022603.1\|WP_085097335.1\|2543784_2544483_+\|queuosine-precursor-transporter	unknown	unknown	gnl\|CDD\|376842
NZ_AP022603.1\|WP_085097430.1\|2541362_2541947_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|188483
NZ_AP022603.1\|WP_085097436.1\|2528719_2529016_+\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|238219
NZ_AP022603.1\|WP_085097379.1\|2522156_2522711_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371273
NZ_AP022603.1\|WP_085097341.1\|2541976_2542768_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|236210

Protein	Function_ID	Function_description	E-value
NZ_AP022603.1\|WP_085097364.1\|2530446_2530890_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	3.13556e-07
NZ_AP022603.1\|WP_085097357.1\|2533347_2535120_-\|acyl-CoA-synthetase	gnl\|CDD\|236097	PRK07788, PRK07788, acyl-CoA synthetase; Validated.	0
NZ_AP022603.1\|WP_085097347.1\|2539735_2540539_+\|mycofactocin-coupled-SDR-family-oxidoreductase	gnl\|CDD\|274889	TIGR03971, short-chain_dehydrogenase/reductase_SDR, SDR family mycofactocin-dependent oxidoreductase. Members of this protein subfamily are putative oxidoreductases belonging to the larger SDR family. All members occur in genomes that encode a cassette for the biosynthesis of mycofactocin, a proposed electron carrier of a novel redox pool. Characterized members of this family are described as NDMA-dependent, meaning that a blue aniline dye serving as an artificial electron acceptor is required for members of this family to cycle in vitro, since the bound NAD residue is not exchangeable. See EC 1.1.99.36. [Unknown function, Enzymes of unknown specificity].	3.37684e-130
NZ_AP022603.1\|WP_085097354.1\|2538221_2538827_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|380056	pfam17925, TetR_C_20, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present the transcriptional regulator KstR that regulates a large set of genes responsible for cholesterol catabolism. This is important for Mycobacterium tuberculosis during infection, both at an early stage in the macrophage phagosome and later within the necrotic granuloma.	1.07915e-24
NZ_AP022603.1\|WP_085097351.1\|2538908_2539739_+\|mycofactocin-coupled-SDR-family-oxidoreductase	gnl\|CDD\|274889	TIGR03971, short-chain_dehydrogenase/reductase_SDR, SDR family mycofactocin-dependent oxidoreductase. Members of this protein subfamily are putative oxidoreductases belonging to the larger SDR family. All members occur in genomes that encode a cassette for the biosynthesis of mycofactocin, a proposed electron carrier of a novel redox pool. Characterized members of this family are described as NDMA-dependent, meaning that a blue aniline dye serving as an artificial electron acceptor is required for members of this family to cycle in vitro, since the bound NAD residue is not exchangeable. See EC 1.1.99.36. [Unknown function, Enzymes of unknown specificity].	9.99881e-140
NZ_AP022603.1\|WP_085097433.1\|2536744_2538208_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143410	cd07091, ALDH_F1-2_Ald2-like, ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins. ALDH subfamily which includes the NAD+-dependent retinal dehydrogenase 1 (RALDH 1, ALDH1, EC=1.2.1.36), also known as aldehyde dehydrogenase family 1 member A1 (ALDH1A1), in humans, a homotetrameric, cytosolic enzyme that catalyzes the oxidation of retinaldehyde to retinoic acid. Human ALDH1B1 and ALDH2 are also in this cluster; both are mitochrondrial homotetramers which play important roles in acetaldehyde oxidation; ALDH1B1 in response to UV light exposure and ALDH2 during ethanol metabolism. 10-formyltetrahydrofolate dehydrogenase (FTHFDH, EC=1.5.1.6), also known as aldehyde dehydrogenase family 1 member L1 (ALDH1L1), in humans, a multi-domain homotetramer with an N-terminal formyl transferase domain and a C-terminal ALDH domain. FTHFDH catalyzes an NADP+-dependent dehydrogenase reaction resulting in the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2. Also included in this subfamily is the Arabidosis aldehyde dehydrogenase family 2 members B4 and B7 (EC=1.2.1.3), which are mitochondrial, homotetramers that oxidize acetaldehyde and glycolaldehyde, as well as, the Arabidosis cytosolic, homotetramer ALDH2C4 (EC=1.2.1.3), an enzyme involved in the oxidation of sinapalehyde and coniferaldehyde. Also included is the AldA aldehyde dehydrogenase of Aspergillus nidulans (locus AN0554), the aldehyde dehydrogenase 2 (YMR170c, ALD5, EC=1.2.1.5) of Saccharomyces cerevisiae, and other similar sequences.	0
NZ_AP022603.1\|WP_085097333.1\|2544479_2545109_+\|allophanate-hydrolase-subunit-1	gnl\|CDD\|367142	pfam02682, CT_C_D, Carboxyltransferase domain, subdomain C and D. Urea carboxylase (UC) catalyzes a two-step, ATP- and biotin-dependent carboxylation reaction of urea. It is composed of biotin carboxylase (BC), carboxyltransferase (CT), and biotin carboxyl carrier protein (BCCP) domains. The CT domain of UC consists of four subdomains, named A, B, C and D. This domain covers the C and D subdomains of the CT domain. This domain covers the whole length of kipI (kinase A inhibitor) from Bacillus subtilis. It can also be found in S. cerevisiae urea amidolyase Dur1,2, which is a multifunctional biotin-dependent enzyme with domains for urea carboxylase and allophanate (urea carboxylate) hydrolase activity.	7.03252e-77
NZ_AP022603.1\|WP_085097373.1\|2524249_2524483_+\|acyl-carrier-protein	gnl\|CDD\|376348	pfam00550, PP-binding, Phosphopantetheine attachment site. A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of the anguibactin system regulator AngR has the attachment serine replaced by an alanine.	0.000204342
NZ_AP022603.1\|WP_085097370.1\|2524479_2528616_+\|AMP-binding-protein	gnl\|CDD\|341253	cd05930, A_NRPS, The adenylation domain of nonribosomal peptide synthetases (NRPS). The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.	3.0298e-51
NZ_AP022603.1\|WP_085097338.1\|2542764_2543769_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	8.40685e-35
NZ_AP022603.1\|WP_085097382.1\|2521290_2522160_+\|TauD/TfdA-family-dioxygenase	gnl\|CDD\|225086	COG2175, TauD, Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism].	8.82242e-74
NZ_AP022603.1\|WP_085097344.1\|2540535_2541330_+\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|131478	TIGR02425, putative_gamma-carboxymuconolactone_decarboxylase, 4-carboxymuconolactone decarboxylase. Members of this family are 4-carboxymuconolactone decarboxylase, which catalyzes the third step in the catabolism of protocatechuate (and therefore the fourth step in the catabolism of para-hydroxybenzoate, of 3-hydroxybenzoate, of vanillate, etc.). Most members of this family are encoded within protocatechuate catabolism operons. This protein is sometimes found as a fusion protein with other enzymes of the pathway, as in Rhodococcus opacus, Streptomyces avermitilis, and Caulobacter crescentus. [Energy metabolism, Other].	7.23405e-13
NZ_AP022603.1\|WP_085097360.1\|2531111_2533307_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	4.08802e-134
NZ_AP022603.1\|WP_109750544.1\|2522748_2524257_+\|AMP-binding-protein	gnl\|CDD\|180293	PRK05857, PRK05857, fatty acid--CoA ligase.	0
NZ_AP022603.1\|WP_085097335.1\|2543784_2544483_+\|queuosine-precursor-transporter	gnl\|CDD\|376842	pfam02592, Vut_1, Putative vitamin uptake transporter.	4.41476e-45
NZ_AP022603.1\|WP_085097430.1\|2541362_2541947_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	3.08333e-15
NZ_AP022603.1\|WP_085097436.1\|2528719_2529016_+\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|238219	cd00371, HMA, Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.	2.81421e-13
NZ_AP022603.1\|WP_085097379.1\|2522156_2522711_+\|hypothetical-protein	gnl\|CDD\|371273	pfam10862, FcoT, FcoT-like thioesterase domain. Proteins in this family have a HotDog fold. This family was formerly known as domain of unknown function 2662 (DUF2662). The structure of Rv0098 from M. tuberculosis suggested a thioesterase function. Assays showed that this protein was a thioesterase with a preference for long chain fatty acyl groups. The maximal Kcat was observed for palmitoyl-CoA although longer and shorter molecules were also cleaved. In solution this protein forms a homo-hexameric complex.	2.07416e-71
NZ_AP022603.1\|WP_085097341.1\|2541976_2542768_+\|SDR-family-oxidoreductase	gnl\|CDD\|236210	PRK08267, PRK08267, SDR family oxidoreductase.	1.16234e-128

>NZ_AP022603.1|WP_085097357.1|2533347_2535120_-|acyl-CoA-synthetase
MSKLTDLALQTAGALGESVSKYAERGAAELHYARKMFEAGALKMDPLTFANLLADIARWGEIGMIPALNARRNPNGIAIIDDDGQLTFAELDAAAHAVANALRARGVSDGDGVALLIRNHRWFLIALYGAARVGARMILLNSEFSGPQIKEVSEREGAQLIIHDDEYTAAVAEADPPLGKLRALPTNPDSDTPSGSTAQTLADLIAGGDDRPAPRATKQAKIIILTSGTTGTPKGANRAAPPSLAPIGGILSAVPFRSGEVTSLPAPMFHALGFLHCTIAMMLGNTLVLRRRFKPATVLADIEEHRVTAMVVVPVMLSRILDYRDTLETKPDTSSLRIVFVSGSQLGAELATRAMKDLGPVVYNLYGSTEIAFATIARPQDLQKDAATVGPVVKGVRIKIVDDDGNEVPQGQVGRIFVGNTFPFEGYTGGGGKQVIDGLMSSGDVGYFDADGLLYVSGRDDEMIICGGENVFPAEIEDLLSGHPEIVEATALGVDDKEWGSRLRAFVVKAEGAEIDEDAVKAYVRDNLARYKVPREVVFIDELPRNPTGKILKRVLRDIGEGVATVEDTVANLSEKIADVLHPDGGDDPK
>NZ_AP022603.1|WP_085097360.1|2531111_2533307_+|acyl-CoA-dehydrogenase
MPIAIAEEHLALADSVRALVAKVAPAEVLHEALETPLDNPPPYWRAAAEQGLTGVHLAESVGGQGFGILELAVVLAEFGYGAVPGPFVPSAIASALIAAHDPDYPLLAELAAGTSIAAYAIDSGLTATRLGEVLVIRGEARAVPAAGQADVLVLPVAIDSGEEWVVLNAADLEIEPRVSVDPARPIADVRANAIEIGDDRVLTTLSRARARALMSTLLSAEAVGVARWCTDSASGYAKIREQFGRPIGQFQAVKHKCAEMIATTERATAAVWDAARALDEATAGDPAATQHEFAAAVAATLAPVAAQHCAQDCIQVHGGIGFTWEHDTNVYYRRALALVACFGRAADYPQLVVDAATSTGMRGIDIDLDPQTEKLRGEIRAEVDALKALPGGPERNAAIAEGGWVQPHLPRPWGRAASPIEQVIIAQEFSAGRVKRPPMGIAAWLIPSIVAYGTEAQQQRFLPATFRGEMIWCQLFSEPGAGSDLASLTSKATKVDGGWRITGQKIWTTGAQYSAWGALLARTDPSAPKHQGITYFLLDMTAPGVEVKPLRELTGNAMFNTVFIDDVFVPDDMVLGEVNRGWEVSRNTLTNERVSIGSSEPAFLANLDLFVEFLADGQFDQIEQNHAGRLIAEGHAAKLLNLRSTLLTLAGGDAMPSAAISKLLSMRTGQGYAEFAVASFGTDGIVGDPDTPSGRWAEYLMGSRATTIYGGTSEVQLNIIAERLLGLPRDP
>NZ_AP022603.1|WP_085097364.1|2530446_2530890_-|GNAT-family-N-acetyltransferase
MTEIREIRAGETGSAAEAMLLLRPRWRTAGAVVDLIDDRLRPAGYRLVGAFEESSDSAVSVLGFREVWSTAWGHYLYVDDVSTLETARGKGFADELLRWVIAEAERLGCEEIHLDSGVGSDRAAAHRLYMRNHLRISSHHFSLELGG
>NZ_AP022603.1|WP_085097367.1|2529787_2530234_-|hypothetical-protein
MPPGRALATSAAGIVRDAIDASGGLGEPWRLDDADAVRSGDLLFVVEVDDLGWMMTAYLIDGGEATPIAVLADENGNSPVRALAGWLRNAAGPMTWKRVKPGLYRSGGYLVGQLDTGEWFAEGPGVDQCFEHKHDAQAACTAARSFAQ
>NZ_AP022603.1|WP_085097436.1|2528719_2529016_+|heavy-metal-associated-domain-containing-protein
MTCMMCARRVEKALNKVDGVQASVKIATKIATVDAAPGVTVEQLCAVVEQAGYQATEHVPGAAAAEDTGADDAASDTEPAARGWWAKLRARFTRNRAE
>NZ_AP022603.1|WP_085097370.1|2524479_2528616_+|AMP-binding-protein
MTPVRLPLSRSQRNIYNGVAQDNDPALYLIGRRYRFHPVDLPVLLSALEATIRASPVQLCVLAEDPGADYPVLVPTLAAQDLVRVCADDAADTAGQLADSWAGGLLGVPLARYVVRTDDAGAVAGLDAYCHHLLLDGGGTAIFEDRLGRRLAGDTESICVEDGLHALARAHRHEAARIDESLERLSTVTAAELTAEATGHRPGSPNVPGHAVRGVPAGSITICGADFDALQDVCTEHRVPLNVLVAAAAVAVDAGAAGSTDALLVHTIDPRFGEPDLDVASCLVNSVAQPVRFAPFASAGDLVRSMDRGYVRALRRRWLREERYRRMYLAINRTTGVAALTLNFLPQPCAPALQPFLTDPPTTTDIGPIEGNTVAAVADQAQRRLQISIWARADTPPDAVTAGMAARIGAALNSFAAHWDRPVAAAVGAWQVITADGTLAPGTDAIPERRGAPAWFTPAPAGLDRRPQLRSWLAWLEANDVAAGEVLVITDDGTDRTVDLLLAGHLAGCPYSPCDSAQQAEARAQRIAEAGFAVRIVDPATVSLPAEIDAGTGARIDTRLAAVAADPGLRARTAYLMPTSGTTGEPKLVEISHGSLAAFCAGIADAYRWAPPDTVLQCAPLTSDISVEEIFGAVCAGATLIRSTATRTGDLAALARDVAGSGATVLDLPTALWQLLGADPDALDAVGNSRLRQVIIGGEPVRSGAVDRWSESPATRAISLISSYGPTETTVIVSRLTLARAGVAIEPAARPRVGRPLLAGTVFVAFGEIVVVGDLVAAGYLGGPAESFGSVLLADGIARPAFATGDRVAVSNGHPVFAGRRDALVKIGGRRIDTAALTRRIGADTAIVDLAVEATDGALGVWFCTHRTRAGHDDPAAAGGIRAVLAAAGVPSYFVTGVPGIARKAGGKVDRAALPQPAEPSEHPDRGDRADALAALWSAALGRPIGTESSLLAEGVGSLDLIKILPPTRRILGWSLSIFDLISADTAANLAAAVPPESTALDPVTVAEIDADMRAAKLVRAPQPLPGAPVAGHTDTIVVLGASGILGRGFAEAVLAARRAGTPLPEVVLAMRSALPDEQPWAALARCPGVRLERLRAGFGPDEIDALLRETGAATLINCIGSANMLVPYAQLRPANLDIVPVTVQACLRRSVRLVHLSTSVVVNDVGAAHVVDPRWAPYPYAAVKALAEIVVAGSPEALDFTMVRLPRILGEPDQLTESTDILVSMVDACAALGARPALAVSEEVTTGHAAAQAILGRLPGAGGAGRLGRGITALRGTVVDYPMFLADFAPREVDAAVWKQQLDDSNWARAHPGRWSIIDAWLSLGARLDGRSYGEFLAGLPSVGLDVGAATHIDAPAENLRELCGAVPRLIARVPVG
>NZ_AP022603.1|WP_085097373.1|2524249_2524483_+|acyl-carrier-protein
MTEPLRDRILAALAEVLYVEGPDFTDGDDTDLRDLGLDSVRFVLLMTELGVDRESALPQRLADDLTVAGWVRELADP
>NZ_AP022603.1|WP_109750544.1|2522748_2524257_+|AMP-binding-protein
MLTVWQRVAAEAARRPGDVALRRADGSGTLRYGRLDPLTRRIAADFAGAGVGPGDRVLIFSDNGPETYLGVLACARTGAIAVLVDGALPPATVARFAEITTPSAIALAPGAALTEDARPGGLPVIDIGIDSPTDDSGLIADPGVVSAPDDPLAMIFTSGTTGEPKAVLLAHRTFYAVADILAAEGLDWIDWAPGQSTYSPLPATHIGGLWWILNCLMHGNLCITGGEHGASTLEVLTTHAVTTCCLVPTLIGRLVAELRSTGATLPAALRFVGYGGSRAVAADIDVLEAAGVRTAQVYGLSETGCTALCLPTAAGSLTRIAAGAVGRPYPGVLTRLDETGALWVNSPANMLGYWNNPAKTAETLVDGWVNTGDLLDLGDDGYFYIRGRASEMIISGGVNIAPDEIDRIAEGVDGVREAACFEIPDPEFGALVGLAVVPTGPLDAAQTRGLKRDLAARFRRESEAIARPARIITVAAIPRTPSSGKVIRAELARTAAGGRSDD
>NZ_AP022603.1|WP_085097379.1|2522156_2522711_+|hypothetical-protein
MTTTELSPAAQAHLNTSDIAPITEDLLTRVLEPYSHKGCRYLRTASYKATETSMFSLGTFAIAESSYIRSTGHFNAAEMMVCFNQIAYSAFAPAILNEQIPPFRGWSIEDYFDHQLPSMLIKNFSARFSRPINAAGFSARLWCEDFEVVDRTWRYLRIPCTIEFWDADGGFASGEVELAALNIP
>NZ_AP022603.1|WP_085097382.1|2521290_2522160_+|TauD/TfdA-family-dioxygenase
MPLNVKGDGLGAQVTGIDPDHLEDLTGTELRELVYTHKLIVLKDVHPSPRQFLELGRILGEVVTYYEPIYHHHDYPEIFVSSTEQGQGVPRTGAFWHIDYMFMPEPFAFSMVVPLAVPGTDRGTYFIDLAKVWAALPDERQAPVRGTFATHDPRRHIKIRPDDVYRPIGEVWDEITRTTPPISWPTVIRHPRTGEEILYICSSGTTRITDRDGNPLDPALLAELLDHSGQLDPDFTSPFIHTQHYEVGDIVLWDNRVLMHRAKHGTAAGALITHRLTMLDGLETPGYPV
>NZ_AP022603.1|WP_085097433.1|2536744_2538208_+|aldehyde-dehydrogenase-family-protein
MSAVASSVIDDLAARPGTGEAIAVVDPSTEERITEFPDAGPEAVNTAVAAAKASYDSGVWTDIPGRQRAKALWRLGDLIDEHAKAFAELESLDAGMPPMQAEMIVSTCAEFFRYYAGWCTKINGSSYQVQMEGGVNSTHANFHAYTQKEPYGVVGLIYPWNGPLFNACAKIAPALAAGCSAVVKPAEETPLSAVLLERLIAEAGIPEGVANFVIGYGATAGAAITAHPDVEKVAFTGSTEVGKQIMRESADNLKKVTLELGGKSPVLIYEDADLDMAIMMASMGIFVHSGQGCVCGSRVFVQRSVYDRVVAGISMIGENLVLGGPQDEGAMISPLVSQKQLDRVMGYIDQGKRDGAEIVSGGYRLDRKGYFIKPTVVTGVDPETSSLYKEEIFGPVVTILPFDDDDEAIAMANDTNYGLAATAWTTNLARAHNLGKRLNAGMVGLNCQLTFDHNVPFGGYKHSGVGKEFGYEGIDGYLKTKSIWAAL
>NZ_AP022603.1|WP_085097354.1|2538221_2538827_-|TetR-family-transcriptional-regulator
MAIVDADRRGADGPDAADDRVLRIVAEILESDGYDAVALRTVARRARTSLATIYKRYPTRDDLIRAALSRWMDEHRWAGLRQGPGDAEESLYEGEMRMLRTIFEPWERHPGMLKAYYRARSAPGGDALVRRGFDEVLPASREVLAGVDPEFVADLDIVVSNVIYGLLGRFVAGEIGIADILPALERTVFRLTEGYRPAGTR
>NZ_AP022603.1|WP_085097351.1|2538908_2539739_+|mycofactocin-coupled-SDR-family-oxidoreductase
MPALDGKVAFITGVARGQGRSHALRLAADGAAIIGVDSCADIATNCYPMASRAELDETVELVRAAGGRMHASVADVRDYPALAAALQAGVDEFGRLDIVCANAGIAGMAFRELSVEEDLQTWTDVIDVNLVGSFHTAKAAIGHLIAGGRGGSIVFTSSTAGLKGFGGLGGGGLGYAASKHGIVGLMRTLANALAPHSIRVNTVHPTAVNTMMAVNPEMTAFLENYPGGGPHLQNPMPVQMLEPADISAAIAFLASDAAQYVTGVTFPVDAGFCNKL
>NZ_AP022603.1|WP_085097347.1|2539735_2540539_+|mycofactocin-coupled-SDR-family-oxidoreductase
MNGRVAGKRVLVTGAARGMGRSHAVRLAEEGADLILVDICASLPDIDYPLAATEDLAETARLVEEQGRRAITHVVDVRDAAALTAAVDDGVTRLGGLDASVANAGVITGGTWDTTTAEQWRTVVDVNLIGTWNTCAAALPHLVDHGGSLVNISSVAGLKGSPLHTPYTASKHGVVGMSRALANELAAVNVRVNTVHPTGVDTGMRPDALHALLHGERADLGPIFQNALPIVMTEARDVSNAVLFLVSDESRHVTGLEFKVDAGVTLR
>NZ_AP022603.1|WP_085097344.1|2540535_2541330_+|carboxymuconolactone-decarboxylase-family-protein
MTDRGAAMYAEVMTVPAPQPVAPTERALLDVVFGQVWTRPGLSRRDRRFITLACVAAADAEGPLREHVYAALRSGDLSITEIQEAALHFAVYSGWPKASRLNMMIDEQWARIHAERGTPVPPPEPLLPLPTPSDPEARLATGEQAFIDVNCLPFVPTRDNPYSGAGILNFVFGEVWLRPGLGRRERRLLTVACVGFQDAPYPIMSHVYAALRSRDLSFDEMDELILQFAAYYGWAKAATLQAVAHEQQQRVRQELSGQDFAVPK
>NZ_AP022603.1|WP_085097430.1|2541362_2541947_+|TetR-family-transcriptional-regulator
MPDSEPGPGLRERKKIRTRETLRREALRLIAEQGFAATTIEQIAAASEVSPSTFFRYFPNKSALLVPDQLMDPIIDVFLQAPAELSPIAAYRYAVEQVFGQFSDPEWAEEAGRQALMYTLPEAAGPLYRQYIFTIGRITEALAVRLSRPADDPELRIAAGAMTGVMMQALHGTPMQPEMIYRALDFLDAGLPLI
>NZ_AP022603.1|WP_085097341.1|2541976_2542768_+|SDR-family-oxidoreductase
MGKSVFITGAAAGIGRATARRFAELGYTVGGYDLDEAGLATLATEITALGGTPVTGHLDVTDYAELSQRITEFTAATGGRLDLLINNAGILRSGRFPDIDITAQQRMIDINCKGVTNGCHAAYPALRDTPGATVINLCSASAIYGQPELAVYSASKFFVRGLTEALDLEWGADDIRVIAMWPLYVQTAMTDGVHTGTTASLGVNLTAEDVVAAIVAAAEPGPLQRLLHVVHFPVGRQTALMAGAVRFSPAWLTRLVNKRLARL
>NZ_AP022603.1|WP_085097338.1|2542764_2543769_+|ABC-transporter-substrate-binding-protein
MTAPTPTGPTRRGFLALAAAAGVTAVAAGCGSEQSGSEGADGGAVTVTHAFGETTVAAPPTRVVSAGFTEADDLLAVGIVPIATTDWWGEQPYGVWPWARSALGPAQPELLSLADGIQVERIAALRPDLIVAINAGVDAETYRRLSEIAPTIPQAGRAAFFEPWREQASTIGAVAFQGPRMTELIKTVDEGFSAAGTAHPSFTGTKALLLGGSTDWENSVRVSTEGWRTEFLTRLGFHIPKVDGTPAGDGRVLVPLDRIDGALDGADVLIWTTESDEERDRLLAVPQIAALAATKAGRNVFTDRELAGAIAYSSVLSLPVVADRLPPLLAAALG
>NZ_AP022603.1|WP_085097335.1|2543784_2544483_+|queuosine-precursor-transporter
MTGPDRFRPGPGSTPGFAAVGSRYYPGLVAAFTALVIISNVTATKGVAFGPIITDGGFIVFPLTYVIGDVLSEVYGFKAASRAILLGFAMNILAALAFWATVYLPAADFYQNQQHLENVVQAYTQLIAAGLAGFLVGQTLNAWSLVAIKARTREKHLWARLVGSTVVGQLGDTVVFCTIAAGAIGIRTVRDFLVYTALGLVYKTTVEVLLLPVTYRVIAFLKRREPSYQYLP
>NZ_AP022603.1|WP_085097333.1|2544479_2545109_+|allophanate-hydrolase-subunit-1
MKIRDYGDTALLLEFSGTAEVLAAADAVRAAALPGVLDIVPAARTVLLTLSGATVRDRVRDRLSGLPFGAAGDALRPPPGRPDVVVDVVYDGPDLDEVAEHTGLTRQDVVAAHTGRPWRVAFAGFAPGFGYLIGGDPRLAVPRRAEPRTRVPAGAVALAGEFSGVYPRDSPGGWQLIGRTDAVLWDIDRDPPALLTPGRWVGFRAVPGR

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Crispr_ID: NZ_AP022603_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022603_12

2957367-2957475

Orphan

Consensus_repeat	Method
CGCGCAGGCCGCCGCCGAGCTGGCCGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022603_12

>merge|NZ_AP022603|12|2957367-2957475|CRISPRCasFinder
CGCGCAGGCCGCCGCCGAGCTGGCCGACCCGCCGCGCCGAATCGTGCCGCTGGCCGTGTCGGCGTTTCTGACCTCCCGCAAGCGCGCGGCCGCCGCCGAGCTGGCCGAC

>NZ_AP022603|12|10|2957367-2957475|CRISPRCasFinder
CGCGCAGGCCGCCGCCGAGCTGGCCGAC	CCGCCGCGCCGAATCGTGCCGCTGGCCGTGTCGGCGTTTCTGACCTCCCGCAA
GCGCGCGGCCGCCGCCGAGCTGGCCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022603.1\|WP_085095644.1\|2941752_2942592_+\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|369792
NZ_AP022603.1\|WP_085095628.1\|2952278_2953298_+\|cutinase-family-protein	unknown	unknown	gnl\|CDD\|366455
NZ_AP022603.1\|WP_085095634.1\|2948746_2949346_+\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239486
NZ_AP022603.1\|WP_085095619.1\|2963310_2966541_-\|arabinosyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|377388
NZ_AP022603.1\|WP_085095607.1\|2977491_2977929_-\|GtrA-family-protein	unknown	unknown	gnl\|CDD\|225155
NZ_AP022603.1\|WP_085095615.1\|2969956_2973208_-\|arabinosyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|377388
NZ_AP022603.1\|WP_085095632.1\|2949342_2950245_+\|decaprenyl-phosphate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|237058
NZ_AP022603.1\|WP_085095622.1\|2961011_2962598_+\|acyl-CoA-carboxylase-subunit-beta	unknown	unknown	gnl\|CDD\|227136
NZ_AP022603.1\|WP_085095613.1\|2973204_2975139_-\|galactan-5-O-arabinofuranosyltransferase	unknown	unknown	gnl\|CDD\|371991
NZ_AP022603.1\|WP_085095617.1\|2966537_2969843_-\|arabinosyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|377388
NZ_AP022603.1\|WP_163742462.1\|2979125_2980751_-\|DUF2207-domain-containing-protein	unknown	unknown	gnl\|CDD\|378333
NZ_AP022603.1\|WP_085095672.1\|2978653_2979100_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|378988
NZ_AP022603.1\|WP_085095636.1\|2946822_2948754_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|375472
NZ_AP022603.1\|WP_085095642.1\|2942601_2944215_-\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|227766
NZ_AP022603.1\|WP_085095626.1\|2953551_2955444_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|181109
NZ_AP022603.1\|WP_085095640.1\|2944346_2945387_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235777
NZ_AP022603.1\|WP_085095638.1\|2945606_2946812_+\|UDP-galactopyranose-mutase	unknown	unknown	gnl\|CDD\|223636
NZ_AP022603.1\|WP_085095611.1\|2975140_2975920_-\|decaprenylphospho-beta-D-erythro-pentofuranosid--2-ulose-2-reductase	unknown	unknown	gnl\|CDD\|181162
NZ_AP022603.1\|WP_085095609.1\|2975940_2977341_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NZ_AP022603.1\|WP_109750487.1\|2950297_2952241_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP022603.1\|WP_085095644.1\|2941752_2942592_+\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|369792	pfam08282, Hydrolase_3, haloacid dehalogenase-like hydrolase. This family contains haloacid dehalogenase-like hydrolase enzymes.	7.63856e-72
NZ_AP022603.1\|WP_085095628.1\|2952278_2953298_+\|cutinase-family-protein	gnl\|CDD\|366455	pfam01083, Cutinase, Cutinase.	2.39948e-09
NZ_AP022603.1\|WP_085095638.1\|2945606_2946812_+\|UDP-galactopyranose-mutase	gnl\|CDD\|223636	COG0562, Glf, UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane].	0
NZ_AP022603.1\|WP_085095634.1\|2948746_2949346_+\|phosphatase-PAP2-family-protein	gnl\|CDD\|239486	cd03392, PAP2_like_2, PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	3.67441e-17
NZ_AP022603.1\|WP_085095611.1\|2975140_2975920_-\|decaprenylphospho-beta-D-erythro-pentofuranosid--2-ulose-2-reductase	gnl\|CDD\|181162	PRK07904, PRK07904, decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase.	1.20829e-159
NZ_AP022603.1\|WP_085095607.1\|2977491_2977929_-\|GtrA-family-protein	gnl\|CDD\|225155	COG2246, COG2246, Predicted membrane protein [Function unknown].	1.56672e-22
NZ_AP022603.1\|WP_085095632.1\|2949342_2950245_+\|decaprenyl-phosphate-phosphoribosyltransferase	gnl\|CDD\|237058	PRK12324, PRK12324, decaprenyl-phosphate phosphoribosyltransferase.	8.00695e-141
NZ_AP022603.1\|WP_085095622.1\|2961011_2962598_+\|acyl-CoA-carboxylase-subunit-beta	gnl\|CDD\|227136	COG4799, COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism].	0
NZ_AP022603.1\|WP_085095613.1\|2973204_2975139_-\|galactan-5-O-arabinofuranosyltransferase	gnl\|CDD\|371991	pfam12250, AftA_N, Arabinofuranosyltransferase N terminal. This domain family is found in bacteria, and is typically between 430 and 441 amino acids in length. This family is the N terminal region of AftA. The enzyme catalyzes the addition of the first key arabinofuranosyl residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol to the galactan domain of the cell wall, thus priming the galactan for further elaboration by the arabinofuranosyltransferases. The N terminal region has been predicted to span 11 transmembrane regions.	0
NZ_AP022603.1\|WP_085095617.1\|2966537_2969843_-\|arabinosyltransferase-domain-containing-protein	gnl\|CDD\|377388	pfam04602, Arabinose_trans, Mycobacterial cell wall arabinan synthesis protein. Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol.	0
NZ_AP022603.1\|WP_163742462.1\|2979125_2980751_-\|DUF2207-domain-containing-protein	gnl\|CDD\|378333	pfam09972, DUF2207, Predicted membrane protein (DUF2207). This domain, found in various hypothetical bacterial proteins, has no known function.	7.57754e-16
NZ_AP022603.1\|WP_085095672.1\|2978653_2979100_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|378988	pfam12900, Pyridox_ox_2, Pyridoxamine 5'-phosphate oxidase. Pyridoxamine 5'-phosphate oxidase is a FMN flavoprotein that catalyzes the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP). This entry contains several pyridoxamine 5'-phosphate oxidases, and related proteins.	7.61099e-24
NZ_AP022603.1\|WP_085095636.1\|2946822_2948754_+\|glycosyltransferase	gnl\|CDD\|375472	pfam17994, Glft2_N, Galactofuranosyltransferase 2 N-terminal. This is the N-terminal beta-barrel domain found in the polymerizing galactofuranosyltransferase GlfT2 (Rv3808c). This enzyme synthesizes the bulk of the galactan portion of the mycolyl-arabinogalactan complex, which is the largest component of the mycobacterial cell wall such as in Mycobacterium tuberculosis. The N-terminal domain contains two short helices preceding a 10-stranded beta-sandwich with jelly roll topology.	6.48395e-86
NZ_AP022603.1\|WP_085095642.1\|2942601_2944215_-\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|227766	COG5479, COG5479, Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane].	4.49867e-63
NZ_AP022603.1\|WP_085095626.1\|2953551_2955444_+\|AMP-binding-protein	gnl\|CDD\|181109	PRK07769, PRK07769, long-chain-fatty-acid--CoA ligase; Validated.	0
NZ_AP022603.1\|WP_085095640.1\|2944346_2945387_-\|hypothetical-protein	gnl\|CDD\|235777	PRK06302, PRK06302, acetyl-CoA carboxylase biotin carboxyl carrier protein.	0.00108625
NZ_AP022603.1\|WP_085095619.1\|2963310_2966541_-\|arabinosyltransferase-domain-containing-protein	gnl\|CDD\|377388	pfam04602, Arabinose_trans, Mycobacterial cell wall arabinan synthesis protein. Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol.	0
NZ_AP022603.1\|WP_085095609.1\|2975940_2977341_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	1.96475e-49
NZ_AP022603.1\|WP_085095615.1\|2969956_2973208_-\|arabinosyltransferase-domain-containing-protein	gnl\|CDD\|377388	pfam04602, Arabinose_trans, Mycobacterial cell wall arabinan synthesis protein. Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol.	0

>NZ_AP022603.1|WP_085095626.1|2953551_2955444_+|AMP-binding-protein
MAFHNPFIIDGRIEFPRDTSIVEHVENWAELRGDELAYRFLDYSTERDGVACDLTWAQFSARNKAVAARLQQVTELGDRVAILCPQNLDYLVAFFGALYGGRIAVPLFDPSEPGHVGRLHAVIDDCKPSAILTTTEAAEGVRKFFRSRPAKERPRVIAVDAIPDEVAATWVQPPPLTEETIAYLQYTSGSTRIPTGVQITHLNLATNVLQVVEALEGEEGDRGLSWLPFFHDMGLITALLSPMIGYRFTFMTPAAFVRRPERWIREMARKPEDTGGTISVAPNFAFDHAAARGVPKDGAEPLDLSNVKAILNGSEPISAATVRRFNDAFGPFGFPAKAIKPSYGLAEATLFVSTTPSSEEPTIISVDRDELNAGRFVEVAEDSAKAVAQAGAGKVGIGEWAVIVDAESATELPDGQIGEIWISGMNMGTGYWGKPEETRDTFQNLLASRIADSHAEGNEPDATWVRTGDYGAYHNGELFITGRVKDLVIIDGRNHYPQDLEYSAQEASKALRVGYVAAFSVPANQLPDEVFADSHSGLRRDPDDSSEQLVIVGERAPGAHKMEPGPITDDIRAAIAVRHGVTVRDVLLTPAGAIPRTSSGKIGRRACRSAYLDGTLRAGKVANAFPDELD
>NZ_AP022603.1|WP_085095628.1|2952278_2953298_+|cutinase-family-protein
MARTRNESRRKRHLILGLIAAAAVAVVIGLVVVIGVLLYGSRSTPPSPLPPEAKPTTGPSTPGAKPRPEFQSADCPDVQLLVIPGTWESSRTDDPLNPGQFPIALLLPMSRGISAQLPGERVQVYTVPYTAQFNNPLGGDKQMSYNDSRAEGTRTAAKVLTDMNERCPLTSYVLVGFSQGAVIAGDLASDIGNGRGPIAEDLVLGVTLIADGRRQVGVGQSIGPNPGGQGAEITLAEVPMLSTLGLTMSGPRDGGFGKLNDRTNQICAQGDLICDAPEGAFNIANLPNTLNTLAGGAGQPVHAMYGTPQFWVLDGLTATQWTEQWARGLIDNAPHPKHG
>NZ_AP022603.1|WP_109750487.1|2950297_2952241_+|hypothetical-protein
MSVRVSLWCSVAVIAVLFGWGAWQRRWIADDGLIVLRTVRNLMAGNGPVFNAGERVEANTSTAWTYLTLLGGWVAGPVRLEYVVLALSLALSVAGVVLAMLGAARLYAPSLVGRNALLLPAGALVYIAIPPARDFATSGLETGLALAYIGLLWWMMVCWSQRVRRPVPDPADPTGPAGERRAVAFTAAVSAVAGASVLVRPELALLGVLALLLLFIAAPGWRRRAVVFVAGGLLPVGYQIFRMGYYGMLVPSPAVAKDASGSKWSQGLTYLANFNGPYLLWIPAVLLVGTGLVLLVVRSRSWWVRHDAPPGASWLTRTLQAPLAVVAVFVGAGLIQAVYWVHQGGDFMHGRVLLLPMFCMLVPLAVIPVVVPIGRAVSREAGYLLAGATTVLWMALAGWAAWAANSPGLGRDGTWVTDSGIVDERRFYSQATGHAHPLTAADYLDYPRMRAVLVAINNTPEGALLLPSGNYDQWDVVPAIPLPPQLPVNDPARLNPPHTVFFTNMGMLGMNTGLNVRVIDQIGLINPLAMHTQRVERGRIGHDKELFPDWAVAEGPFLKEPPYIPTYLDEDWIVQAGAALGCPETDAMLTAIRAPMGPRRFLSNLLHAAEFTSYRIDRVPEYELARCGLPIPPLRGEPYTGLPATGP
>NZ_AP022603.1|WP_085095632.1|2949342_2950245_+|decaprenyl-phosphate-phosphoribosyltransferase
MSKPAAAPSNVVVGVIKAMRPRQWVKNLLVLAAPLAAWGDDQDFDHQQVLIHVGLAFVVFSLAASSIYLVNDALDVEADRAHPTKRYRPIAAGVVPPWLAYLLSAILGVAALVIGWTVNANLALVIAIYLAMQLAYCFGLKHQAVLDICIVSSAYLIRAIAGGAAADIRLSKWFLLVMAFGSLFMAAGKRYAELQLAERTGAKIRKSLENYTGSYLRFVWTLAATAVVLCYGLWAFERDGSTGSWYAVSMIPFTIAILRYAVDVDGGEAGEPEDIALGDRVLQVLAVGWIGTVVAAIFLG
>NZ_AP022603.1|WP_085095634.1|2948746_2949346_+|phosphatase-PAP2-family-protein
MPEDTGLPDGARPDAARPDNTDWPGDPDAPAPEETALILVQAGLAGRPGVLPAARGLSHLGEHSLGWLIIGALAAVIVPARRREWLTMVVGTFAAHAAAVLIKRVVRRRRPDHPAIAVNVGTPSKLSFPSAHATSTTAAALLAARASGSRLPWLVVPPMLLSRLVLGVHYPSDVAAGAVVGAAVAATTAGIADRLERAA
>NZ_AP022603.1|WP_085095636.1|2946822_2948754_+|glycosyltransferase
MSDVPSGPIGPGQSKAVSLLSRVILPRPGEPLDVRKLYITEADTNSRRAHAPTRTSLDIGGEAEVSFATYFNAFPASYWRRWSILDAVVLRIELTGAARVDVYRSKATGARISVAGAPAVSESDDKPAVVEFEISLAPFEDGGWIWFDITTDTAAVLHSAGWYAPVEAPGRADIAVGIPTFNRPADCVSALAALTSDPLVDAAIGAVIVSDQGDRKAKDHPDFDAAAARLGDRLSIHNQPNLGGSGGYSRVMYEALKHTDCEQILFMDDDIRIEPDSILRALALNRFAKSPTLIGGQMLNLQEPSHLHVMGEVVNRANFMWTNAPFTAYDHDFARYPLDDVEEADSQLLHRRIDVDYNGWWMCMIPRSVAEELGQPLPLFIKWDDADYGLRAAEHGYPTVTMPGTAIWHMAWSDKDDAIDWQAYFHLRNRLVVAAMHWDGEVKGLVVSHLKATIKHLMCLEYSTVAIQNRAIDDFLAGPEHIFSILESALPEVHRMRKAFPDAVVLPGATELPAPSGRVRVHKPPVAPPMILLRLAQGLVHQFRRADPAHHQRPQLNVPTQDARWFLLCKVDGVTVTTADGRGVVYRQRDRAKAAGLLRASLRRQLKLARKFDTMRRIYREALPELSSKQKWETVLLEADVDA
>NZ_AP022603.1|WP_085095638.1|2945606_2946812_+|UDP-galactopyranose-mutase
MTDSFDLFVVGSGFFGLTIAERVATQLGKRVLVVERRPHIGGNAYSEPEPETGIEIHRYGAHLFHTSNTRVWDYVREFTDFTGYQHRVFAMHNGQSYQFPMGLGLVSQFFGRYFSPDEARALIAEQAAEIATADAANLEEKAISLIGRPLYEAFVKGYTAKQWQTDPKDLPAANITRLPVRYTFDNRYFNDTYEGLPVDGYTAWLQNMAADERIEVRTDTDWFDVRDELRAANPSAPVVYTGPLDRYFDYAEGRLGWRTLDFQVEVLDGCGDFQGTPVMNYNDPDVPYTRIHEFRHFHPEREYPADKTVIMREYSRFADDDDEPYYPINTETDRSLLAAYRARAKAETAAAGVLFGGRLGTYQYLDMHMAIASALNMYDNVLAPHLRDGASLSEPRNDVKE
>NZ_AP022603.1|WP_085095640.1|2944346_2945387_-|hypothetical-protein
MPNRRRRKLSRAMSAVAALAVASPFAAVAAAELVADSQPAPQHREFTQAAVITDLPNELLSALSSGLSQFGINMPPLPTGVNPAGAQPLTGLTTPGLASPGLTSPGLTSPGLTSPGLTSPGLTSPGLTSPGLTTPGATAPGLATPGLATPSVTDLTTPGLVSPALTDPAGTAAATVPGLTDAAGLTTPGGPTAGLTVPGVGDLANPALTPGGTAPIGLGTTDLTSPLGVGNPIGLPGEQPIAAPIGLGADTYPILGDPSLGGLGGLGTGMPASKPGLISDLSSAANSLGAGQAVDLLKGVLMPTIMGAIKSAGPAAAAAPAAVAPAAEAAAAVAPVAAAVAPAAIG
>NZ_AP022603.1|WP_085095642.1|2942601_2944215_-|N-acetylmuramoyl-L-alanine-amidase
MVSSRAPRLLFSALAATAVLVPWAINGLPTDRPAPRALDATVVTKPLAGVGGGTTVREVSQQQPFSVVALTGDDLTGTTAQVRARRDDGGWGPWYQADALESNGSDANRDGPRGTDAVFVGRTTAVQIKVSRPAGAPVSPPARPRADTDLGYRPVNVDEPIGNLNAILITPPQAPADGAFSPPAAAILPGQAPQVITRAQWGADERLRACGPPAYDAGVKAAVVHHTAGSNDYSPQDSVAIMQSIYAYHTQTLGWCDMAYNALVDKYGQVFEGRAGGLDRPVEGSHTGGFNRDTWGVAMLGDFETVPPTDIQLRNTGRLIGWRLALAHVDPHGTVALTSAGGSYTFYPAGATPTLPTIFAHRDVGITECPGVAGYGRMDEIRDIAARFNVPPAPPTLEERLREGAIGARWLASGGAAGPLGVPTSPESAAAGDARYATFERGAVYWSPATGAQPLTGAIYAAWASLGFERGLLGLPTSAEIQEPLWVVQNFQHGTLNFDRETGQVTRVSDAVAVLLPPPADSGPPVQLERFSPISVG
>NZ_AP022603.1|WP_085095644.1|2941752_2942592_+|Cof-type-HAD-IIB-family-hydrolase
MEPNFREPQTAPLLIATDVDGTLLDDDERVSDRTRAVLGAAMADGTRFVLATGRPPRWIAPVVDDLGFAPMAVCANGAVIYDPAADRVLSVRTLSVEQLVELAEIAAAVMPGAGLAVERIGSGAHDAVTPQFVSSPGYQHAWLNPDNTEVSLTDLLSAPAIKLLIRRAGVSSAAMARQLAPHVDGQGDLTYSTDNGLIEVVPAGISKATGIAEIAAPHGIGAEEIVSFGDMPNDIPMLTWAGHGVAMGNAHPEVMGVADEVTARNSEDGLARVLERWWG
>NZ_AP022603.1|WP_085095622.1|2961011_2962598_+|acyl-CoA-carboxylase-subunit-beta
MEGPQVTDAVEQSANTTAAKLAQLRERLEVAKDPGDEKSRARRDRKGLPTARARIHALLDPGTFLEIGALARTPGDPNAYYGDGVVTGHGTINGRPVAVFSHDQTVFQGTVGEMFGRKVARLMEWAAMVGCPIIGINDSGGARIQDAVTSLAWYAELGRRHELMRGIAPEISIILGKCAGGAVYSPIQTDLVVAVRDQGYMFVTGPDVIKDVTGEDVSLDELGGADAQARYGNIHQVVDDEAAAFKYVRDYLEFLPGNTFDDAPVINAGLEPEVTSHDMELDTMVPDSDNQAYDMMEILLRIFDDGDVFQVAEQRGQAIITAFARVDGRSVGVIANQPMYMSGAIDNEASDKAAGFIRFCDSFNLPLVFVVDTPGFLPGVEQEKGGIIKRGGRFLNAVVEADVPKVTITIRKSYGGAYAVMGSKQLSADLNFAWPTARIAVIGAEGAAQLLVKRFPDPTAPEVQKIRADFIEGYNLNMATPWIAAERGFIDAVIEPHDTRLMLRKGMNLLRDKQNLHRIQRKHGLTPI
>NZ_AP022603.1|WP_085095619.1|2963310_2966541_-|arabinosyltransferase-domain-containing-protein
MTSTLTPPSTPAPASPPRADRDVTVARWIATVAGLLGFFLAVSIPLLPVVQTTATLNWPQGGQLGSVTAPLISQAPVSLEATIPCQVIRDLPPTGGLVLGTAPAKGKQAALNALMVTVTSSRVDVTDRNVVVASMPRSKVADPRCERIEITSSEAGTYATFVGLTKDDGSPARTGFPDPNLRPAIVGVFTDLAGPAPAGLSFSATIDTRFTTTPTTLKLAAMVLAVVCTVVALLALWRLERTDGHRARRLIPGRWRTFTLVDVVVIGTFVLWYIAGANSSDDGYILGMARVADHAGYMSNYFRWFGSPEDPFGWYYNLLALMTHVSDASIWIRLPDLICSLVCWLLLSREVLPRLGPAVAASRPALWTAGMVLLAAWMPFNNGLRPEGQIATGALVTYVLVERAIGSSRLSTAALAIITAAFTLGVQPTGLIAVAALVAGGRPIIRILVRKRRQFGIWPLLAPLLAAGTVILAVVFADQTLATVLEATRIRTAIGPSQEWYTENLRYYYLILQTVDGSMSRRFGFMITGLSLFTTMFIMLRRKRIPGVARDPVWRLIGVIFATIFFLMFTPTKWVHHFGLFAAVGAAMAAVTAVLVSPIVLRSARNRMTFLAALLFVMALTWASTNGWWYVSTYGVPFNNDVPAIGGITVSTMLFAAFAVAAVWAFWLHFAPPGRGQGRAVRALTAAPLPIAAGFMVLVFVASMLIGAVRQYPTYSNAWANLRAFSGGCGMADDVLVEPDPNDGFLTPVGGPFGPLGALGGDKPVRFSANGVPEKIVAESIRLNNPKPGTDYDWDQPIKLKTPGINGSTVPLPYGLDPARVPVAGSYTEGPQQPATLASAWYELPPADDAHPLVVVTAAGTITADSVAKGRTEAQAVELEYGHPGPDGAPVPGGRLTPYDVGPTPSWRNLRYPREQIPADATFVRVVANDRSLSQGDWVAVTPPRVPELRSVQEYIGSEQPVLMDWAVGLVFPCQQPMLHANGVTEVPKFRISPDYLAKLQSTDTWQDGMNGGLLGITDLLLRAHVMAAYLSRDWGQDWGSLHRFETVVDAPPAQIELGTATHSGLWKDGRIRIKP
>NZ_AP022603.1|WP_085095617.1|2966537_2969843_-|arabinosyltransferase-domain-containing-protein
MPDDRPARPDEPAPAATQRPGTTRTARLIALLAGIAGILLCGLVPLLPVQQSTATINWPQAPAADGNVESVTAPLVSGAPQSLDVSVPCTAIATLPPAGGVALSTIPAAGIDASRNGLFIRANAETVTVAIRDTVAAFAPRADVESGKCSVIHVWADAGGVGADFVGIPGATNTLAVDKKPQVAGVFTDLKSPPVPGLSARVDIDTRFITSPTALKLAAMVLGVLCVLISIVALARIDAASTGRRPAHPWRRLLRVSPSTWLADLGVLGTLGLWHLLGATSSDDGYNTTIARISDDAGYHANYYRYFGATEAPFDWYQSLLAQLTHVSTQGVWLRLPATLAGLGTWLLLSRFVLPRLGRRLADSPITVWTGAAVFLAAWLPFNNGLRPEPLIAFGTLAVWALVENSIATRRLWPTAVAIVVAVFSVTTAPQGLIALAPLLVGTRALAAVLRSRRAAAGLLAQLAPLAAALTLVFVLVFRDQTLAAVAESARIKYKVGPTIAWYQDFLRYYFLTVEESVDGSLTRRFAVLLMLLCLFGVLAVLLRRGKVPGAANGPLWRLVGATAVGLLLLTFTPTKWAVQFGAFAGLAGALGAVTAFAFARVGLHSRRNLALYVMALLFVLAWATSGINGWFYTNNYGVPWFDKQPVLAGYPVTTMFLVGAIVAGLLAGWLHFRMDYAGHTEVADTRRNRMLASTPMLVVAVLMVLLEVGSLAKGFAGRYPVYTTGKANLAALSAPAGCGMADDVLVEADTNAGLLTPVDGQRFGKYGPLGGTSPVGFTPNGVNETLEPAEPVVGNPGTVNSAGAPDKPNIGVAYAAGTGGGYGPVGVNGSRVFLPFGLDPARTPVMGSYGENAVAAKATSAWYQLPARSPARPLVTVAAAGAIWSYDEEGSFNYGQSLKLEWGVREADGRFRALSQSQPIDVIPQKAWRNLRFPLAWAPPEADVARIVAEDPNLSEDQWFAFTPPRVPILQTAQEFLGSTTPVLADIATAANFPCQRPFTEHLGVAELPEFRILPNFKQMVISSNQWQSAEAGGPFLFIQALLSTATVPTYLRDDWYRDWGSIERFIRVVPAASAPDAVIDTGVQRVFGWYRPGPIRALP
>NZ_AP022603.1|WP_085095615.1|2969956_2973208_-|arabinosyltransferase-domain-containing-protein
MNATSGELPSTSVTETGKDYRTAKLIAVVAGLLGTLLALATPLLPIKQTTAELNWPQHGELASVTAPLISYVATDLEITVPCRLAAGLTGNKTVLLSTVPKQAPKAVDRGLLIERVNGNLNVIVRNTPVVVAPMRAVLSPACQELTFTAHADKVTAEFVGLTEADSSDSTDPTDTDADQPLRGERGGYDFRPQIIGVFTDLDGPAPDGLSFSANLDTRYSSAPTTLKLVAMILGVLCTAVALGALHVLDTADRVRHRRFLPARWWSVKPLDAVVLVTLLWWHFVGSNTSDDGYIFTMAKVSQDAGYMANYYRWFGTPEAPFGWYYDLLAAWSQVSTASIWMRLPTLLMAVACWWVISREVIPRLGAAVKHSAAARWTGAGMFLVTWLTLNNGLRPEPIIAVGILLTWCSVERAVATSRLLPVAIACIIGALTLFSGPTGIASIGALVVAIGPLRTILARRSQRFGLPALLAPLAAAGTVAVILIFRDQSLVAEMQASSFKSLVGPSLAWFEEPTRYTRLFMATPDGSIARRFVVLSLLAALAMVVAMMLRKGHIPGTAGGPARRITGITVISFLALMLTPTKWTHHFGVFAGLAGSIGALAAVAVTAHVLVSRRNRTIFGAVVLFVLALSFASVNGWWYVSNFGVPWSNEFPAVKFGFTTLLLGASLLALALATYFHFSARGERPWRPTRMGQLLHSPLALASWAMVLFEVVSLTVAMISQYPAWSVGRSNLQALTGKSCGLATDVMVEQDANAGVLRPIGTTPGSALGAVTAIGFGPNGIPSNVSPDAVTGQPGIGLQSDTDPTMVTDAEPGTEGGTRAALGINGSRAQLPYGLDPRAVPVMGSWSPGLQQPAVLRSAWYRLPDRASLSADHPLLVISAAGRFEAGEVVVQWAGEDGKPTGSMGFADVGSAPAWRNLRAPLRAIPAAATQIRIVATDDDLALNHWIAVTPPRIPSLQTLQDVVGSQDPVLLDWLVGLAFPCQRPFGHNNGVVEVPKWRILPDRFGAEANSPVMDYLGGGPLGITELLFRAVTVPTYLKDDWFRDWGSLQRLDQFYPAAQPAELALGTAVRSGLWSPGPLRRS
>NZ_AP022603.1|WP_085095613.1|2973204_2975139_-|galactan-5-O-arabinofuranosyltransferase
MRAAVTGAGHLLAAALVAVVVAVLGLAAIGRVEWPAFPSSNQLHALITVAQFGCLAALVAAGWLWRRGRRALAWLTAVTFLSAFVVGTLGMALGATRLYLFGVSVDQQFRTEYLTRLTDSPALHDMTYAGLPPFYPPGWFWLGGRVAALTGTPGWEMYKPWAIASIAMAAAAAFALWARLVRFEQALAVTAATTATTLAYASAEPYSAIITVLLPPILVLAWAGLRASGTSAASDGSEQAESGTGLRASGTSAAGYSGWAALVGTGIFLGVTATFYTLLLGLAALTVTVMAVTLAARRRSIAPLLRLAVVAAIAIGIALITWGPFLLAASRQPMSGTGSAQHYLPGDGAVLTFPMLQFSLLGALCLLGTGWLIARATTSVRAGALAVGVLSIYLWSLLSMVTTLAGTTLLSFRLQPTLTVLLAAAGAFGFIELAAAAANRWNRRLIAVATVLGFIGAMSFAQDIPNVLRPDLAVAYTDTDGHGQRADRRPPGAERFYADIDAAIREATGRDRDRTVVLTADYGFLAFYPYYGFQGLTSHYANPLAQFDRRAAEIESWSELKTAKEFVAALDGLAWDPPTVFLMRRGGGSGSGATYTLRLAEDVYPNQPNVRRYTVELDAALFADEHFTVTSFGPFILAIRKPSA
>NZ_AP022603.1|WP_085095611.1|2975140_2975920_-|decaprenylphospho-beta-D-erythro-pentofuranosid--2-ulose-2-reductase
MIDATGNPQTILLLGGTSEIGLAICRRYLRNSAAKVILADLPNAPKREAAIAELRAAGAKEVDYLDFDALDTASHPGVIDAAWAGGDVDVAIVAFGVLGDAEELWQNQAKAVAAAGINYTAAVSVGVLIGAKMREQGFGQIIAMSSAAGERVRRSNFVYGSTKAGLDGFYLGLGEALAEYGVRVLVIRPGQVRTTTTVEHWQATGAKEAPFTVDADEVAELAVTSALAGKSLVWAPGQVRYLMSVLRHIPRPIFRKLPL
>NZ_AP022603.1|WP_085095609.1|2975940_2977341_-|FAD-binding-oxidoreductase
MATQLPLTPQALTGFGRTAPSVAQVLRTPDVEVIAEAVRRVADADAAGPAYLRRGILGRGLGRSYGDQACNGGGIVVDMTALNRIHSISAETAIADVDAGVSLDQLMRAALPFGLWVPVLPGTRQVTVGGAIASDIHGKNHHSAGSFGNHVLSLDLLMADGEVRTLTPDGPESELFWATVAGNGLTGIVVRARIAMTRTETAYFIADGVATADLDETVAVHQDGSEDNYTYSSAWFDLISGPPKLGRAAVSRGSLARLDQLPDKLARDPLKFSAPQLPAIPNLFPVNFMNKASLSLIGEAFYRMSGDYQGKIVNLTQFYHMLDITSGWQYAYGPAGFAQHQFLVPPDALEEFKGIIRWMHTQRQYSALNVFKLFGPGNRAPLSFPMQGWNVALDFPNKPGVNEFLNEIDRRAMEFGGRVYTAKDSRVTAESFHRMYPRIDEWIAVRRKADPNGVFASNMARRLELL
>NZ_AP022603.1|WP_085095607.1|2977491_2977929_-|GtrA-family-protein
MSEHVQPGAHDIPVTGRLPLRTQVLRFVITGGLSAIVDFGLYVLLYLILGVHPDLAKAVGFIAGTTTAYLINRRWTFQAAPSTARLIGVWVLYLTTFVVQVGLNHLFLALLNYTPAAVAVAFVIAQGTATVINFVVQRAVIFRIK
>NZ_AP022603.1|WP_085095672.1|2978653_2979100_+|pyridoxamine-5'-phosphate-oxidase-family-protein
MVSVTAPDDAPITVLSEEESWDLLSGSALGRLVTTVGDQLEIFPVNFVVQNRTLLFRTAEGTKLFATVTNDQVLFEADDHGLSEGWSVIVRGHGEVLHGADEIAEADQAGLYPWLATVKLRYVRITPTQVSGRRFVFGPEPDTGQLPG
>NZ_AP022603.1|WP_163742462.1|2979125_2980751_-|DUF2207-domain-containing-protein
MRSRTALLAALLLVALCTPFAPAAHAAPAPITVALDLDLQDDGTLAVSTTTTVPEGSPAIGVIPLAVPVEGNRTQHFAISDIETEGGAQADIDGDQLRIVAPAGTTTVRYRVRGTVADSPGLQQFTWILTAGWSAPVAALTGTFSSPTPRPDSPICAYGQIGVRRLCTMTQTQGGGAVSFEHRHLEAGMVAVFSVLLPAGTVTATAQFTDTVTTAGGGPAADRAASWAVLAATLLGLGLTAAAALRRRTDRAAVTGAVAPAELLAAHDGVVDFVSPDGVLPGQVGALLAGHARPADFGATVFDLAVRNYLWITEAPDRSGAVDFHIARRAPLDGAITDHERAVVEAILPNDRKSVSVAELARGGAGAVGTAAAVDEWRCERRIMLRRIGFGLLAIGALAAVGTALAGGPVLWATAVLILGAGVAVAATLLPARNRSGTRVAAALTAMRIQLATLDPDGIEPSSRPVLFQRGLSYAHALGDLRIWLRRWGGGPKATDWYRPAGDRPLAAGLPVLAALLDGIAAGPESTPAPTAAPKPGRRAH

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Crispr_ID: NZ_AP022603_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022603_13

3143867-3143983

Orphan

Consensus_repeat	Method
GTACGCCGTCACCGGTGTGTCGTGTACGCAATTGCGCGCTGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022603_13

>merge|NZ_AP022603|13|3143867-3143983|CRISPRCasFinder
GTACGCCGTCACCGGTGTGTCGTGTACGCAATTGCGCGCTGGGCGCGGGGTGGTTCGGCCAGCGCGCACTTCTGTACGCCGTCACCGGTGTGTCGTGTACGCAATTGCGCGCTGGGC

>NZ_AP022603|13|11|3143867-3143983|CRISPRCasFinder
GTACGCCGTCACCGGTGTGTCGTGTACGCAATTGCGCGCTGGGC	GCGGGGTGGTTCGGCCAGCGCGCACTTCT
GTACGCCGTCACCGGTGTGTCGTGTACGCAATTGCGCGCTGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022603.1\|WP_163742501.1\|3146762_3146927_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_011895469.1\|3154267_3155137_+\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|378401
NZ_AP022603.1\|WP_085092724.1\|3137703_3138834_-\|DUF4350-domain-containing-protein	unknown	unknown	gnl\|CDD\|379527
NZ_AP022603.1\|WP_085100132.1\|3141092_3141557_+\|GatB/YqeY-domain-containing-protein	unknown	unknown	gnl\|CDD\|224526
NZ_AP022603.1\|WP_085092726.1\|3138830_3139478_-\|DUF4129-domain-containing-protein	unknown	unknown	gnl\|CDD\|379261
NZ_AP022603.1\|WP_085097446.1\|3145090_3146719_-\|N-6-DNA-methylase	unknown	unknown	gnl\|CDD\|280533
NZ_AP022603.1\|WP_163742693.1\|3139459_3141046_-\|glycerophosphoryl-diester-phosphodiesterase-membrane-domain-containing-protein	unknown	unknown	gnl\|CDD\|236090
NZ_AP022603.1\|WP_085097443.1\|3147078_3148878_+\|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|239026
NZ_AP022603.1\|WP_085100129.1\|3143178_3143679_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_AP022603.1\|WP_085097449.1\|3153523_3154165_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_AP022603.1\|WP_085092720.1\|3135362_3136691_-\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NZ_AP022603.1\|WP_085100126.1\|3141540_3143082_-\|efflux-MFS-transporter-LfrA	unknown	unknown	gnl\|CDD\|184957
NZ_AP022603.1\|WP_085092718.1\|3133366_3134308_-\|RDD-family-protein	unknown	unknown	gnl\|CDD\|224628
NZ_AP022603.1\|WP_052537336.1\|3155316_3155865_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085092722.1\|3136690_3137707_-\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NZ_AP022603.1\|WP_085092719.1\|3134357_3135350_+\|stage-II-sporulation-protein-M	unknown	unknown	gnl\|CDD\|376676
NZ_AP022603.1\|WP_011895467.1\|3155896_3156448_-\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NZ_AP022603.1\|WP_011895471.1\|3152733_3153432_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_AP022603.1\|WP_052544279.1\|3149330_3152417_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_AP022603.1\|WP_085097440.1\|3144090_3145101_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP022603.1\|WP_011895469.1\|3154267_3155137_+\|metal-dependent-hydrolase	gnl\|CDD\|378401	pfam10118, Metal_hydrol, Predicted metal-dependent hydrolase. Members of this family of proteins comprise various bacterial transition metal-dependent hydrolases.	5.00873e-90
NZ_AP022603.1\|WP_085092724.1\|3137703_3138834_-\|DUF4350-domain-containing-protein	gnl\|CDD\|379527	pfam14258, DUF4350, Domain of unknown function (DUF4350). This domain family is found in bacteria, archaea and eukaryotes, and is approximately 70 amino acids in length.	4.03086e-06
NZ_AP022603.1\|WP_085100132.1\|3141092_3141557_+\|GatB/YqeY-domain-containing-protein	gnl\|CDD\|224526	COG1610, COG1610, Uncharacterized conserved protein [Function unknown].	2.2385e-43
NZ_AP022603.1\|WP_085092726.1\|3138830_3139478_-\|DUF4129-domain-containing-protein	gnl\|CDD\|379261	pfam13559, DUF4129, Domain of unknown function (DUF4129). This presumed domain is found at the C-terminus of proteins that contain a transglutaminase core domain. The function of this domain is unknown. The domain has a conserved TXXE motif.	6.34927e-05
NZ_AP022603.1\|WP_085097446.1\|3145090_3146719_-\|N-6-DNA-methylase	gnl\|CDD\|280533	pfam02384, N6_Mtase, N-6 DNA Methylase. Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.	2.36546e-10
NZ_AP022603.1\|WP_163742693.1\|3139459_3141046_-\|glycerophosphoryl-diester-phosphodiesterase-membrane-domain-containing-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	4.512e-13
NZ_AP022603.1\|WP_085097443.1\|3147078_3148878_+\|molybdopterin-dependent-oxidoreductase	gnl\|CDD\|239026	cd02108, bact_SO_family_Moco, bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they contain one single pterin cofactor and part of the coordination of the metal (Mo) is a cysteine ligand of the protein and that they catalyze the transfer of an oxygen to or from a lone pair of electrons on the substrate. The specific function of this subgroup is unknown.	1.25588e-70
NZ_AP022603.1\|WP_085100129.1\|3143178_3143679_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	0.000199132
NZ_AP022603.1\|WP_085097449.1\|3153523_3154165_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.299e-14
NZ_AP022603.1\|WP_085092720.1\|3135362_3136691_-\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	1.1975e-55
NZ_AP022603.1\|WP_085100126.1\|3141540_3143082_-\|efflux-MFS-transporter-LfrA	gnl\|CDD\|184957	PRK14995, PRK14995, SmvA family efflux MFS transporter.	1.59843e-92
NZ_AP022603.1\|WP_085092718.1\|3133366_3134308_-\|RDD-family-protein	gnl\|CDD\|224628	COG1714, COG1714, Predicted membrane protein/domain [Function unknown].	1.80839e-20
NZ_AP022603.1\|WP_085092722.1\|3136690_3137707_-\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	3.10532e-102
NZ_AP022603.1\|WP_085092719.1\|3134357_3135350_+\|stage-II-sporulation-protein-M	gnl\|CDD\|376676	pfam01944, SpoIIM, Stage II sporulation protein M. SpoIIM is on e of four stage II sporulation proteins that is necessary for the forespore inside the mother-cell to be properly internalized through the breakdown of peptidoglycans trapped between the membranes of the septum separating the forespore and the mother-cell. The four proteins working in sequence are SpoIIB, pfam05036, SpoIIM, SpoIIP, pfam07454, and finally SpoIID, pfam08486. D, M and P are in a complex with each other and the complex assembles in a hierarchical manner such that M, which serves as a membrane anchor, recruits P to the septum and P, in turn, recruits D to the septum.	1.52871e-38
NZ_AP022603.1\|WP_011895467.1\|3155896_3156448_-\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	2.01193e-15
NZ_AP022603.1\|WP_011895471.1\|3152733_3153432_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.98008e-09
NZ_AP022603.1\|WP_052544279.1\|3149330_3152417_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	0

>NZ_AP022603.1|WP_085100129.1|3143178_3143679_-|TetR-family-transcriptional-regulator
MSALSADPAAPLADIAAAAHVGRSTLHRYFPERADLIRALAVHVHAISTAAVDAADPTNGPPVAALRRVVESQLDLGPVVSHIYGDPLVLSDAELMTHLDTGDDAIIEALHRAAEGRTKVPSGWARRVFWALLEAGFEAARQDGTPRHEVVDAIMTTLTEGLINPT
>NZ_AP022603.1|WP_085100126.1|3141540_3143082_-|efflux-MFS-transporter-LfrA
MSPRLDSVATSSTPTTTPARAWLALAVLMLPVLLIAIDNTVLAFALPLIAEDFRPSATTQLWIVDAYSLVLAALLVPMGALGDRVGRRRLLLIGATGFAAVSAAAAFAPTAGALVGARALLGVFGAMLMPATLSLIRNIFTDDSARRLAIAIWASCFTAGAALGPITGGALLEHFHWGAVFLVAVPILLPLLLLAPRLVPESRDPNPGPLDPISIALALLAMAPSVWAIKSVAHEGFTGIALAAFGLGVVATTLFVWRQNRSETPMLEMRLFRYAPFSSSVLANFLSVVGLIGLLFFLAQHLQLVLGLPPLMAGLVTLPGAVCSVIGGLAVVRLAQRYAPHSLIVIGLLLVAAGFALVLLFRNDLTVAAVIASLVTLEIGVGISQTVSNDTIVAAVPPAKAGAAAAVSETAYELGAVIGTATLGTVLTASYRSNIELPHGLSEPAAAQAGESIGGATAVANEVPPEMAARLLDSARTAFDSGIAPMAGIAIALTLIAVAVVIRAFRGRPTVGP
>NZ_AP022603.1|WP_085100132.1|3141092_3141557_+|GatB/YqeY-domain-containing-protein
MSELKDRLRSDLTAAMKAQDKLRVATLRMLLAALQAEETSGKEPIELDDSDVLRVLAREARKRGEAAQIYITNGRGELAATERAEASVIEEYLPSPLSADEIASIVNTAIANVAEEIGERPGPRNMGRVMAIAKEIAGDKADGARLSAAIKDRL
>NZ_AP022603.1|WP_163742693.1|3139459_3141046_-|glycerophosphoryl-diester-phosphodiesterase-membrane-domain-containing-protein
MRRRSGGRTGCRVVKNRSHRQDRGHAQHRPDPAPVTTPPDHPLPGPPGPVDPATGPAPGYDGPPVPPTDPAGAAHDAAGPPPGYDAPPGYSAPGPTAPAGPPPAYNAPGYTAPAGPPPGYGLPPQSPPPGYPAGPPPQGPPPGYGPPPGYPQGPPPQGPPPGYGPPQGPPPGYGPPPGYRGAPGPLPGYGRTGYPAPAPLPTFVPEGVPGIIPLRPLTLSELYNGAIGYIRRSPKATLGLTTIVIVGTQLLALVLQLGPLALLGKLDLLQDPDVDLVVSSLLQVPAALAGLLAGVLLGGMLTVVIGRAVFGSSITIAEAWERIRPRLPALIGLAALEFFGVLLVLAVVIALITALAAANTVVAVAVGLPLALAVLVGLGFLWVQLAFAPTAIVLERLPVMTAIRRSLTLVRGDFWRILGILVLTGIITGMIASALGFPFTFAGGLVTTMADQPGLMVLGAVLTAAGGSIGQIVASPFSAGVSVLLYTDRRMRAEAFDLVLRTGAAQRAQHPQIDPSADPTDLLWLTRR
>NZ_AP022603.1|WP_085092726.1|3138830_3139478_-|DUF4129-domain-containing-protein
MADPAVDIGAEQARELARQELADPRYPRATLTDRLNEWLSDVLDRIVMKASDVPGGWLTILVLTVLLVVAVVLTVRLIRRTMHTEDAAAPLYAGAELSAEQHRRRAEDCAARGDWAAAIRHRLRAVARALEESGVLALVPGRTASELAEAASAPFPGLSGEFHSAAAVFNDVTYGERPGDEGGYRLVAGLDDHLLGAPVGGPPGPAPAEGWSAIR
>NZ_AP022603.1|WP_085092724.1|3137703_3138834_-|DUF4350-domain-containing-protein
MTAPAKPRRRRTRTWVTVGIALLAILGAAALTALLTSPRSGGLLDGDSTSADGAHALVSLLREQGVQVHLAGTVAEAADAAGPDTLLVVAQTRYLPAADLLARLADVDADLLLIQPSSPTRELLAPGVQRDHRPARTQPNCELRAARQAGTIDLRSATTFRALDDPRDFSSCYGGAVVRYHDGDRVITVVGASEFLQNGALTDAGNAALAMNLAGEQPRLVWYAPQRPEDDGAGSATVFQMIPQRVYWIVGQLIVVVALLALWQGRRLGPLVAERLPVVVRASETVEGRGRLYRSRRARDRAADALRAAARQRLLPRLGLTRTAGPDQILGALAAQTAMPPGHLEHLLYGPVPSGDEDLQALAHALDDIERKVAHP
>NZ_AP022603.1|WP_085092722.1|3136690_3137707_-|MoxR-family-ATPase
MTHFSPEQTPQHPAPPQAPPQADPGQAARDALRALRAEIGKAVVGQDAVVSGLVVALLCRGHVLLEGVPGVAKTLLVRTLAAALDLEFKRVQFTPDLMPGDVTGSLVYDARTAAFEFRPGPVFTNLLLADEINRTPPKTQAALLEAMEERQVSVDGEPKALPDPFIVAATQNPIEYEGTYQLPEAQLDRFLLKLNVPLPPRDQEIAILGRHAHGFDPRDLSAIRAVAGPAELAAGRAAVARVMVADEILGYIVEIATATRHSPALSLGVSPRGTTALLGTARAWAWLSGRNYVTPDDVKAMAKPTLRHRIALRPEAELEGAVPDAVLDGILASVPVPR
>NZ_AP022603.1|WP_085092720.1|3135362_3136691_-|DUF58-domain-containing-protein
MVLTARAALLALLGVAPIAVSPWPATTFAVLLAALGCAILADLTLAAHPDALSYRRSGPSSIRLGQTAELTLTVRNDGPRTARGLIRDAWAPSAVARPREHRLTLAPGASETLVTQLNPVRRGDQHAAAVTARCLGPLGLAGRQRSRPVPAELRVLPPFLSRKHLPSRLARLRQIDGSIPVLVRGEGTEFDSLREYVVGDDVRSIDWRASARRNDVVVRTWRPERDRRVVLVLDTGRTSAGRVGLDPISNSPAAGGWPRLDWSMDAALLLAALAARAGDHVDFLAHDRETRAAVFGAGRTELLSRVVDAMAPLEPALLESDAAATVSAVLRRTRGRALVVLLTELNASALEEGLLPVLPRLCARHQVLIASVADPRVQELAAGRADAAAVYDAAAAERARNERRGIASRLRMMGVEVVDAPPEELAPALADRYLGMKAAGRL
>NZ_AP022603.1|WP_085092719.1|3134357_3135350_+|stage-II-sporulation-protein-M
MDVDAFVLAHRDTWDRLEDLIRRRRRLTGAEADELVDLYQRVSTHLSMVRSSAGDSALVGRLSTLVARARAAVTGAHAPLRREFVRFWTVSFPVVAYRARYWWLGTTAAFFAVAILIAVWVSHNPDVQAAIGTPAEIAQIVDHDFESYYSDHPAGLFALQVWTNNAWLAVICVAFSVLLGLPIPYVLFLNAANLGVMAGLMAGAGKTSFMLGLLIPHGLLELSAVFLAAAVGMRLGWSVIAPGDRPRVQVLAEQGRAVVAVAAGLVVMLFISGLLEALVTPSPLPTAMRIAIGVAAEALFIGYIWHFGRRAERAGDSGDLADAPDVVPTG
>NZ_AP022603.1|WP_085092718.1|3133366_3134308_-|RDD-family-protein
MSAPPTGSIVTGDAVVLDVQIAQLPVRAVSALIDIVVMGLGLILGTLLWALTLSRLDPAFSAAVLIIFTALVIVGYPVIFETATRGRSLGKLAMGLRVVSDDGSPERFRQALFRGLASIVEIWSLTGSPAVITSLLSAKGKRLGDIFAGTMVISERGPKLSPPPPMPPQLAGWASSLQLSGLGPEQAEMARQFLSRAPSLQPWVREDMANRIAAEVAARISPPPPPGTPPQYLLAAVLAERHRRELARLRVTPVGPVPTAGHPGQAWPPAPMPAPMPPAPMPAPMPPAPAPQWQRPASARPAQPDPGGFTPPD
>NZ_AP022603.1|WP_085097440.1|3144090_3145101_-|hypothetical-protein
MAARPSAKAAAWPLFDAIVARATLREVNPWQPDGGFAPDYPTLARLLAVPLRLGAESRSGVPALAVDVWVAHELRRAGLDPDAVWPRAEPPRVVDRDVLAFIRAIPKGMGRDELLARLRDGSGGVGTASASIAGKNYLKQVDVIVSSWQTGPELLISTKRMDSSFGKNAANRVEESYGDAKNLALRHPLAALGFVYALRSTAYTEERRQFDWITDLLVKLGREDDAYDACALIVPEWDDDAPEATAVPEVPQAPDAEPDGWGSGGLFDLPEIEDVHAAHAVDVDAELAALPVVTLRHDLVPAELDPARFFRRMLEIMLDNSSVLQHEAARARRAAH
>NZ_AP022603.1|WP_085097446.1|3145090_3146719_-|N-6-DNA-methylase
MLAMPTGDDDARRKARGAFFTPEPVARFLFDWAVRRPGDDVLEPSCGEAVFLHQARPGHTGRLTGVEIHPASARRAQRGLRDAGITATVVARDFFCHNEFGDYDAVVGNPPYIRYQDFTGEARARSREAALRAGVALPRLASSWAAFTVHAAGQLRPGGRLALVLPAELLSVNYAAGVRQFLMDNFAAVGLVLFQERVFPGVLEEVVLLLADGYTPAGPGAGHMDLWQVRDADGLTGLSDARRWTPPAGGAKWSGGLMSAAGQAAFDDAVGAGFAPLQHWGETTLGMVTGNNRFFALSPDRVDALGLADDDVVALSPPGSRHLRGLSLTAGTWRELGDGGAAGYLFRPAGEPSAAARSYIRAGENLDVHRAYKCRVRSPWWRVPYLRPADLFLTYMNADTPRLTSNRARAHHLNSVHGVYLRDELRADGIDLLPLAALNSVTLLGAETAGRAYGGGLLKIEPREADHLPVPGPELVRAHAAGLRRVRPGVAARLRAGRLLEAVAVVDEVLLAAVPAGQLAAIRADHADLTARRVARGRSRGG
>NZ_AP022603.1|WP_163742501.1|3146762_3146927_-|hypothetical-protein
MLRYAIPGFTLIAVLVMLTAAVLQSNLLWIVINIGLVLYCIVWIGWERRRGPRE
>NZ_AP022603.1|WP_085097443.1|3147078_3148878_+|molybdopterin-dependent-oxidoreductase
MFLDERPVTVGDGAGAPPRRPDRRPPEARGRIDLGSFGGGIAQVPARLPALRLRRRWFGALWLVVAAVIGLLVLVLVARQLRDYAWMQDFIRRYPGTSTSYAPAVTTGFPAWLRWQHFFNGVLLMFIVRSGLQILADHPRLYLNAGCRPGTEWLRLRGPVPADRMDKTDPARVWTSKDDAVALPGWLGVPGFRHSIGLARWWHFTFDLLWLLNGAVFYVLLFATGQWQRIVPQSWTVLPNAASTLVQYASLQFPVNAGFTNYNGLQLLGYFSTVFIAAPLALITGLLQAPAVAARFGTARGPLNRQVARSVHFGVLVWMVAFVAGHVTMVLCTGVVGNLNHIVLGTDTQEYRAVMLAVAGICTVALLWLLATPLTVRYPRLVQRTGRAVVGPIKEWMERIHPRATYRERDITPYHWSNGRLPDSPHYRRLRAGGWADYRLTVGGLVAHPVQLSYRELLALPKHEQVTGHYCIQGWSGIAKWGGVAMADVLDIVRPLPTARWVVFTSFADGAEPDTGRYYACHRIAHMREPTTLLAYEMNGAPLSEVHGAPLRLRNELELGFKMVKWIESIEFVASIDDVGWGHGGYNEDHEYFGYRMPI
>NZ_AP022603.1|WP_052544279.1|3149330_3152417_-|MMPL-family-transporter
MTDGSADAPSQAKRPGRRANGSTDPADTREYSERLATLARFTLRHKALVIGVWLGAAVVLALLFPQLETVVRQQSVDLIPRDAPSLQTVDRMSAAFGEEGSKTMVFVAMEDPTGLTPTARQRYGELVRRLQAEGDHVLLVQDLLADPITEAQAVSADRKAWYLPVGVTGTLGDPTAAESLNAVRDIAAEVFTGSTTTVQVTGPPATFSDMIASAEHDLLLISIATAGVIALILLIVYRSVFTALLPLLVIGLSLAVGRGVLSALGEMGMPVSQFTVAFMTAILLGAGTDYTVFLISRYHEQRRAQVPADQAIIHATASIGRVILASAATVALAFLAMVFARLSVFAALGPACAIAVLFGFLATVTLLPPVLSLAAKRGIGEPKSDRTRRYWNSVAVAVVRRPVPLLIVSLAILLALSAAAATIKISYDDRKGQPDTTASNQGYQLLDRHFRKDVVISEFLVVENPTDMRTGRGLADLDEMASRVSQIPGVTRVSGVTRPTGERLDQAELAWQNGQIGDKMAGAVAEGNSRKDDLAKLTGGADQLADGLAQLDGTVRTALAPLAGILTQAQSAGTQVNQFRPLLQQLSATAPAVDQAIQSGPGLRPLANQAQNAITQLDPLVGALNTSPWCAATPQCAQIRDQVKILVSLRDSGFFDQIADLGDRYDPATNATVGGTLANVQNAVASLDKAFGALGDPDDLATNLRRLQEGIGQLASGAQALATGVRTLADSNIEMLSGMSQIATQLQNSSRAAADSDSSSGFYLPANAFENRQFTDVAKQFLSPDGKTARFMIESSHDPYSVEAMELASRITDTANTARPNTSLADATVSVAGFPAVNSDIQRFLWADFAQLAVATIIIVGVILVLLLRALLAPLYLLGTVVLNYLASLGIGVVVFQWGLGYEIAWPVPLLAFIILVAVGADYNMLLVSRLREESGTNIRVGVLRTVANTGAVITSAGLIFAASMFGLMVGSVAIMIQAGLIIGFGLLLDTFLVRTLTVPAIATLLREASWWPSKATRTPVADTATQK
>NZ_AP022603.1|WP_011895471.1|3152733_3153432_+|TetR/AcrR-family-transcriptional-regulator
MGADATKVLRPTVVCQDGHVRTRSKRWGGRTGAERRAERRQRLIDAATEIWSESGWAAVTMRGVCAKTGLNDRYFYEDFKTRDELLVAAWDGVRNEMLGEVSATLAERIGQPPMETIRVTIAAVVDRIAEDPGRAKILLAQHVGSSPLQDRRAVALQEATHLVIAASEPHLRPEADETALRMDTLVAVGGFVELITAWHAGLLDVIQGEIVEHTSRLAETLAERYLVDDAGL
>NZ_AP022603.1|WP_085097449.1|3153523_3154165_-|TetR/AcrR-family-transcriptional-regulator
MSAEERHRNRRTRLIEAAMELIGTHGVAAATVTAVCAESGVTSRYFYQHFPDRDALLRAVYQQLYATFQEVIVDAIPDAGAPREVLAYAPIRGLVSMINNDPRLGRILFVESATEPLLRELRSDMMTGFTDLVLREARLHLDIADSAVGVAHLASTLGVGGLFEVLRRWLDGELEFTTDELVQHCAGFLGSLGSYVLLQNAVESATTKAKPQS
>NZ_AP022603.1|WP_011895469.1|3154267_3155137_+|metal-dependent-hydrolase
MSDDSSTRPTTRVVPKPRRVRFDMPAETSRQHFVDGDLVMSHFVSTLSATFPEGEDFFIRSVREYRDHISDADLKEAVKGFIAQEATHRHQHRLLNDRLQAMGYPTEGIDRHIKKLVGRLEKRFSPKMRLAVTAALEHYTATFAEIILTSDEAQELIGYTEVRPILLWHALEECEHKAVAFDVYETVGGSERTRVWGMRIASLLLFTELVIQTTRSLAGDRAAYNPVRLLRSLRAFRHNPLFSRAAIERFRSYTHAGFHPDDWDSAEILERWTKELFDADGGQQLRSNV
>NZ_AP022603.1|WP_052537336.1|3155316_3155865_+|hypothetical-protein
MSASAHVFYELLSGVAMPFASVIGPVPAATGWGMSTAVVLRMAERADKRHEAVLGVVNGLFLTTVLAHFIHWPKRWRFGVPSLSECEGLCGPILVPYNGILYISGLSAVAGLLENGRRGAVRGAIVPLLGVPVLLRLQRMEFRRLSLQARRNPRWWNRRLQMQPPDRSTSSDPDQQVLGAES
>NZ_AP022603.1|WP_011895467.1|3155896_3156448_-|carboxymuconolactone-decarboxylase-family-protein
MLALTDARERAAQCGIPDAMAELSVFRIALHQPPVAVALHGMLEALLWKGALDARLRELIIMRIGWVTDSVYEWTQHWRVARLLDVPERDLLGVRDWQNAGHFGEAERAVLAATDETLRDGTISDETWAECQRALHGDPAVLVELVAAIGNWRLFSALLRSLHVPLEDGLEGWPPDGVRPSVD

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Crispr_ID: NZ_AP022603_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022603_14

3391887-3391987

Orphan

Consensus_repeat	Method
GCTGTCCAAGTGCCTTCATGCCTTGGGCTCCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022603_14

>merge|NZ_AP022603|14|3391887-3391987|CRISPRCasFinder
GCTGTCCAAGTGCCTTCATGCCTTGGGCTCCCGAGGCAGGCCGAGGAGGCGCTCGGCGGTGTTTATCGGCTGTCCAAGTGCCTTCATGCCTTCGGCTCCCG

>NZ_AP022603|14|12|3391887-3391987|CRISPRCasFinder
GCTGTCCAAGTGCCTTCATGCCTTGGGCTCCCG	AGGCAGGCCGAGGAGGCGCTCGGCGGTGTTTATCG
GCTGTCCAAGTGCCTTCATGCCTTCGGCTCCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022603.1\|WP_085096662.1\|3400011_3401010_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085096659.1\|3401914_3402565_+\|DUF4190-domain-containing-protein	unknown	unknown	gnl\|CDD\|379388
NZ_AP022603.1\|WP_085096695.1\|3383754_3384945_+\|flavin-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|173848
NZ_AP022603.1\|WP_085096802.1\|3395895_3396684_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|236110
NZ_AP022603.1\|WP_085096692.1\|3384959_3385811_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|132386
NZ_AP022603.1\|WP_085096804.1\|3393115_3394663_-\|fatty-acid--CoA-ligase-family-protein	unknown	unknown	gnl\|CDD\|236072
NZ_AP022603.1\|WP_163742141.1\|3397048_3397798_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237057
NZ_AP022603.1\|WP_085096701.1\|3381901_3382507_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085096799.1\|3401193_3401841_+\|DUF4190-domain-containing-protein	unknown	unknown	gnl\|CDD\|379388
NZ_AP022603.1\|WP_085096677.1\|3390885_3391842_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173838
NZ_AP022603.1\|WP_085096689.1\|3385825_3386725_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|132257
NZ_AP022603.1\|WP_085096656.1\|3402583_3403153_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085096671.1\|3394717_3395875_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173841
NZ_AP022603.1\|WP_085096680.1\|3389935_3390889_-\|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl\|CDD\|173838
NZ_AP022603.1\|WP_085096698.1\|3382529_3383588_-\|ferredoxin--NADP-reductase	unknown	unknown	gnl\|CDD\|99810
NZ_AP022603.1\|WP_085096665.1\|3397799_3399947_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_163742138.1\|3396855_3397065_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085096686.1\|3386721_3387303_+\|flavin-reductase	unknown	unknown	gnl\|CDD\|376575
NZ_AP022603.1\|WP_085096807.1\|3388768_3389884_-\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|235596
NZ_AP022603.1\|WP_085096683.1\|3387422_3388772_+\|MHS-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340927

Protein	Function_ID	Function_description	E-value
NZ_AP022603.1\|WP_085096659.1\|3401914_3402565_+\|DUF4190-domain-containing-protein	gnl\|CDD\|379388	pfam13828, DUF4190, Domain of unknown function (DUF4190). This integral membrane domain is functionally uncharacterized. One of the membrane helices contains two GXXG motifs that are usually associated with dimerization.	1.46346e-12
NZ_AP022603.1\|WP_085096695.1\|3383754_3384945_+\|flavin-dependent-monooxygenase	gnl\|CDD\|173848	cd01159, NcnH, Naphthocyclinone hydroxylase. Naphthocyclinone is an aromatic polyketide and an antibiotic, which is active against Gram-positive bacteria. Polyketides are secondary metabolites, which have important biological functions such as antitumor, immunosupressive or antibiotic activities. NcnH is a hydroxylase involved in the biosynthesis of naphthocyclinone and possibly other polyketides.	5.7279e-155
NZ_AP022603.1\|WP_085096802.1\|3395895_3396684_+\|SDR-family-oxidoreductase	gnl\|CDD\|236110	PRK07831, PRK07831, SDR family oxidoreductase.	2.20714e-163
NZ_AP022603.1\|WP_085096692.1\|3384959_3385811_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|132386	TIGR03343, 2-hydroxy-6-oxo-6-phenylhexa-24-dienoate_hydrolase, 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase. Members of this family are 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, or HOPD hydrolase, the BphD protein of biphenyl degradation. BphD acts on the product of ring meta-cleavage by BphC. Many species carrying bphC and bphD are capable of degrading polychlorinated biphenyls as well as biphenyl itself.	4.6698e-80
NZ_AP022603.1\|WP_085096804.1\|3393115_3394663_-\|fatty-acid--CoA-ligase-family-protein	gnl\|CDD\|236072	PRK07656, PRK07656, long-chain-fatty-acid--CoA ligase; Validated.	0
NZ_AP022603.1\|WP_085096698.1\|3382529_3383588_-\|ferredoxin--NADP-reductase	gnl\|CDD\|99810	cd06214, PA_degradation_oxidoreductase_like, NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like domain with an iron-sulfur binding cluster domain. Ferredoxins catalyze electron transfer between an NAD(P)-binding domain of the alpha/beta class and a discrete (usually N-terminal) domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal portion may contain a flavin prosthetic group, as in flavoenzymes, or use flavin as a substrate. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently bound FAD as a prosthetic group) are present in chloroplasts, mitochondria, and bacteria and participate in a wide variety of redox metabolic pathways. The C-terminal domain contains most of the NADP(H) binding residues and the N-terminal domain interacts non-covalently with the isoalloxazine rings of the flavin molecule which lies largely in a large gap betweed the two domains. Ferredoxin-NADP+ reductase first accepts one electron from reduced ferredoxin to form a flavin semiquinone intermediate. The enzyme then accepts a second electron to form FADH2 which then transfers two electrons and a proton to NADP+ to form NADPH.	4.1938e-98
NZ_AP022603.1\|WP_085096677.1\|3390885_3391842_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	8.41578e-29
NZ_AP022603.1\|WP_085096689.1\|3385825_3386725_+\|VOC-family-protein	gnl\|CDD\|132257	TIGR03213, Biphenyl-23-diol_12-dioxygenase_1, 2,3-dihydroxybiphenyl 1,2-dioxygenase. Members of this protein family all have activity as 2,3-dihydroxybiphenyl 1,2-dioxygenase, the third enzyme of a pathway for biphenyl degradation. Many of the extradiol ring-cleaving dioxygenases, to which these proteins belong, act on a range of related substrates. Note that some members of this family may be found operons for toluene or naphthalene degradation, where other activities of the same enzyme may be more significant; the trusted cutoff for this model is set relatively high to exclude most such instances. [Energy metabolism, Other].	5.40527e-98
NZ_AP022603.1\|WP_085096671.1\|3394717_3395875_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	2.21962e-136
NZ_AP022603.1\|WP_085096680.1\|3389935_3390889_-\|acyl-CoA/acyl-ACP-dehydrogenase	gnl\|CDD\|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	2.99044e-22
NZ_AP022603.1\|WP_163742141.1\|3397048_3397798_-\|hypothetical-protein	gnl\|CDD\|237057	PRK12323, PRK12323, DNA polymerase III subunit gamma/tau.	0.00691381
NZ_AP022603.1\|WP_085096799.1\|3401193_3401841_+\|DUF4190-domain-containing-protein	gnl\|CDD\|379388	pfam13828, DUF4190, Domain of unknown function (DUF4190). This integral membrane domain is functionally uncharacterized. One of the membrane helices contains two GXXG motifs that are usually associated with dimerization.	2.11323e-10
NZ_AP022603.1\|WP_085096686.1\|3386721_3387303_+\|flavin-reductase	gnl\|CDD\|376575	pfam01613, Flavin_Reduct, Flavin reductase like domain. This is a flavin reductase family consisting of enzymes known to be flavin reductases as well as various oxidoreductase and monooxygenase components. VlmR is a flavin reductase that functions in a two-component enzyme system to provide isobutylamine N-hydroxylase with reduced flavin and may be involved in the synthesis of valanimycin. SnaC is a flavin reductase that provides reduced flavin for the oxidation of pristinamycin IIB to pristinamycin IIA as catalyzed by SnaA, SnaB heterodimer. This flavin reductase region characterized by enzymes of the family is present in the C-terminus of potential FMN proteins from Synechocystis sp. suggesting it is a flavin reductase domain.	4.19071e-55
NZ_AP022603.1\|WP_085096807.1\|3388768_3389884_-\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|235596	PRK05764, PRK05764, aspartate aminotransferase; Provisional.	1.09281e-152
NZ_AP022603.1\|WP_085096683.1\|3387422_3388772_+\|MHS-family-MFS-transporter	gnl\|CDD\|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.38731e-173

>NZ_AP022603.1|WP_085096677.1|3390885_3391842_-|acyl-CoA-dehydrogenase-family-protein
MHFDLDEQQRDFAASIDAALSAADVPAAVRAWGDGNTDPAGALWSTLADLGVPALLVAEEHDGIGAHPVDLVVACQRLGYWCVPGPVTESVAVAPLLLAGDAERSAALASGELIATVALAGDQPRAVNADFAGLTLTAADGQAAVAEVGAGHASIDPSRTLFDVTATGDSWAVDTARAGAFGALATAAQLVGAGSALLDASVEYAKQRTQFGRVIGSYQAIKHKLADVHIALELARPLVYGAALALADGTDTAIRDASAAKVAAGEAGLLAARSALQTHGAIGFTQEHDLSLLLLRVQAIRSAWGDPTVHRRRVLEAL
>NZ_AP022603.1|WP_085096680.1|3389935_3390889_-|acyl-CoA/acyl-ACP-dehydrogenase
MSTTKEERALLVSTVADLIGRHAGPEAVRAALDSERGYDERLWQLLCEQVGAAALVVPEDLGGAGGGLIDAAAVLAELARHLVPSPLLGSTLAELALLSVEEPDGDTLGALAEGSSIGAVVFDPEVVAGGDVADVVIGAADGTLSRWTAFDAHPLPTMDPTRRLSRLTPRETVPLGTDPGLADLAALLLAAEQVGAATRCLELTVAYAKERVQFGRPIGSFQALKHRMADLYVLVQTAGAVVDAALADPSPESAALAHVTATEAFGAVAGEAIQIHGGIAITWECDIQLYFKRAHGSAQLLGTVGDALRRLEPVALA
>NZ_AP022603.1|WP_085096807.1|3388768_3389884_-|pyridoxal-phosphate-dependent-aminotransferase
MDVWQAAAQRQQTHGDLVNLSAGQPRVGPPAPVRAAAAAALQANQLGYTVALGLPELREAIAADCAARYDIEVDLDDVVITTGSSGGFLLTFLACFDVGDRVVVPSPGYPCYRNILSALGCRVLDLPCGPDTRFQPTVAMLDELDPRPDGVIVASPANPTGTVIEPAELAAIAAWCAEHGVRLISDEVYHGLVYPGAPATSSAWQTSRDAVVVNSFSKYFAMTGWRLGWLLVPTDLQRTVDRLTGNFTICPPALSQLAAVAAFTPESVAEAEANLAEYTANRARLLDGLRGIGLTRLAPTDGAFYVYTDVSDHTDDSQEFCARLLAETGVAIAPGIDFDTRDGHRFVRLSFAGPPADVDDAVSRIGGWLAR
>NZ_AP022603.1|WP_085096683.1|3387422_3388772_+|MHS-family-MFS-transporter
MTAPRITPKDPPGTGLRRVVVASMAGTVVEWYEFFLYGTAATLVFSKVFFPQTGSDLDAILAAFVTYAVGFAARPLGGLVFGYFGDRYGRKTLLQLSLLLVGAATFLMGCLPTFGQVGYWAPLLLVVLRFVQGFAVGGEWGGAVLLVAEHSPNRARGFWASWPQAGVPVGNMLATVVLLVLTFLLSDSTFLSWGWRVAFWLSAVVVLIGYYIRTKVTDAPIFVAAQREAEAQIKTALNAIEVIRRYPRPVFTAMGMRFAENIMYYLVVTFSITYLKVHAGVATTNILWYLLIAHAAHFIAIPLVGRASDRFGRRPVYLVGVLLTASWGFFAFPMMDSGNYAVITAAVVIGLLFHALMYAPQPALMAEMFPTRIRYTGVSLGYQVTAIFAGSLAPIIAVKLLADFESSVPIAIYLAGACLVTLIALAFARETAGIDLHDLDRADEAARAG
>NZ_AP022603.1|WP_085096686.1|3386721_3387303_+|flavin-reductase
MTDGPNAAPGFDARAFRNVLGQFCTGVTIITTVHDGEPVGFACQSFAALSLDPPMVLFCPTKVSRSWAAIEASGHFCVNVLAEQQQHVSARFGSREPDKFAGIDWRPGVLGSPVLDGVLAHIECTVATVHDGGDHLVVFGAVRSMSEAPKVKPRPLLFYRGQYTGIEPDKNTPADWRNDLDMFLTATDRDTWL
>NZ_AP022603.1|WP_085096689.1|3385825_3386725_+|VOC-family-protein
MGIRSLGYLRVEATDMAAWREYGLKILGMVEGKGSVEGALYLRMDEFPARLVIVPGERDHLLVAGWETANAADLQGIRDRLTAQGHPFREADAAELADRRVDEMIVLDDPSGNTLEIFHGVALEHRRVVSPYGHTFVTDTQGLGHVVITTTDDVASTRFYRDVLGFRLRDSMKLPPQVVGRPADGDPAWLRFFGVNPRHHSLAIMPGATPSGIVHLMVEVGNSDDVGLCLDRALRRKVKMSATLGRHVNDKMLSFYMKTPGGFDVEFGCEGLEVDDTDWVARESTAVSLWGHDFSIGFR
>NZ_AP022603.1|WP_085096692.1|3384959_3385811_+|alpha/beta-fold-hydrolase
MTTFESTSRYAQVRPDMKLHYHEAGDPSAETVVLLHGGGPGASSWSNFGKNIPVLAERFHVLAVDQPGYGHSDKHTEHEQYNRYSATALLNLFDHLGLESAALVGNSLGGGTAVRFALDNPGRAGRLVLMGPGGLSTNLFAPDPTEGVKLLGRFSMEPTRENLEKFLRIMVYNQKLITEELIDERFAIASQPESLAATRAMGKSFAGADFELGMMWRDVYKLRQRVLLIWGREDRVNPLDGALVALKQIPRVQLHVYGQCGHWAQLEKFDEFNELTVDFLTAG
>NZ_AP022603.1|WP_085096695.1|3383754_3384945_+|flavin-dependent-monooxygenase
MTSIEQRDVQAVLAGIDELLPQLRERAQATEDLRRLPDENIAALEEVGFFKLIQPAQWGGLECDPTVFYEAVRRLASACGSTGWVAGILGIHNWHLAQFDQAAQDEVWGEDASTRISSSYAPMGAGVVTETGDGYLVNGSWNWSSGCDHASWAFLGGPVIKDGRPVDFGSFLIPRTDYQIDDVWHVVGLKGTGSNTIVVKDVFVPRHRFLSYKAMNDHTAAGLVNNTAPVYKMPWGTIHPTTISTPIVGMAYGAYDAHVEHQGQRVRAAYAGEKAKDDPFAKIRIAEAASDIDAAWRQLIGNVAEEYAALTAGEEIPFALRARARRDQVRATGRAIASIDRLFEASGATALSVDAPVQRFWRDAHAGRVHAANDPERAYLIFGNHEFGLPPADTMV
>NZ_AP022603.1|WP_085096698.1|3382529_3383588_-|ferredoxin--NADP-reductase
MTEEPLGTHVLALEIAEVIAETDDARTLVFRVPEGADIAPERLRYSPGQFLTLRVPSEKTGSVARCYSLSSSPHTDDALAVTVKRTVDGYASNWLCDHAHAGLRMHVLAPSGTFVPDRLDADLLLLAAGSGITPMLAIAKSALATGSGQVTLIYANRDERSVIFAAALRELAAAHPDRLTVLHWLESVQGLPDATALGRLAAPFTDRPAFICGPGPFMTAAAEALTGLGVPDERVHIEVFRSLDSDPFAKVVIETDDDDEPPATVVATLDGQTHEFSWPRKAPLLDVLLDKGLDAPFSCREGHCGACAVLCKSGEVEMAVNDVLEPDDLAEGLILACQARPVSNSVEVTYDE
>NZ_AP022603.1|WP_085096701.1|3381901_3382507_-|hypothetical-protein
MNVHRKIFAAAGAAALLSAGLTSTALVQAPEAAAAMASDVKSVPVDPVTQLEMHVTANCVTAEGRCYWDTQANLLTPNGPIGFPGDAWARQTVTLRSNDRDTWQEAEYSAPSGMPREVKGANHANVLSKQLKSINSTEISATYFGGGPIERFRIDGTSIPLNWANGQVSLGPTFIACSNIRVVYGGVNLTTPTACAQVKFS
>NZ_AP022603.1|WP_085096804.1|3393115_3394663_-|fatty-acid--CoA-ligase-family-protein
MMSVPQTTPAVLDRSARIFADRDAVVTPDRTISYAGLRDEVRRAAAAMIDLGVAPADRVAIWSPNTWHWVVGCLAAHWAGAVVVPLNTRYTAAEATDILARTGAPLLLCAGQFLGADRSAELDRDELPALRHIVRIPVQTADPGWDDFVARGADPELLAEADRRAAAVAPTDVSDILFTSGTTGRSKGVLCAHHQSLAGSAAWADCGQMTEADRYLCINPFFHNFGYKAGILACLQTGAALVPQLTFDPVGAMELVAAQRITVLPGPPTIFQTLLDHPARPDHELSSLRFAVTGAATVPVVLIERMQSELDIDIVLTAYGLTEAAGFGTMCRPDDDALTVASTCGRPIADFELRIDGAGEPGAAGEVLLRGPCVMLGYLDDAEATAAAVDADGWLHTGDIGTVDAAGNLTITDRLKDMYICGGFNVYPAEIEQVLSRLPGVAEAAVIGVPDERLGEVGKAFVVRLPGAELDEATVIAHARESLANFKTPRSVEFLDALPRNPGGKVVKPLLRERA
>NZ_AP022603.1|WP_085096671.1|3394717_3395875_+|acyl-CoA-dehydrogenase-family-protein
MIGVEEFRAEVRGWLADNLVGEFAQLKGLGGPGREHEAFEERRAWNQHLAAAGLTCLGWPVEHGGRGLSVAHRVAFYEEYARANAPDKVNHLGEELLGPTLIAFGTPAQQQRFLPRILDVTELWSQGYSEPGAGSDLANVATTATLDGDQWVINGQKVWTSLAHWAQWCFVIARTERGSKRHAGLSYLLVPLDQPGVQVRPIVQLTGDSEFNEVFFDDARADADLVVGEPGDGWRVAMGTLTFERGVSTLGQQIRYARELSGIVALARDNGAIDDPLIRDRLTRAWVGLRGMREYALATMDVERPGQDNVSKLLWANWHRGLGELAMDVLGTSGLVLEDGENPDFSEWQRLYLFSRSDTIYGGSNEIQRNILAERVLGLPREAKG
>NZ_AP022603.1|WP_085096802.1|3395895_3396684_+|SDR-family-oxidoreductase
MNLSIAPAEIEGHNLLSGRVVVVTAAAGTGIGSATARRALAEGADVVISDHHERRLEETRAELAGLGLGRVEAIVCDVTSTAAVDALIAGAAAAMGRIDVLVNNAGLGGETPVVDMTDDEWDRVLNVSLTSVMRSTRAALRYFRDAGHGGSIINNASVLGWRAQHSQSHYAAAKAGVMALTRCSAVEAVEFGVRINAVSPSIARHKFLEKVSSADLLDRLSDGEAFGRAAEPWEVAATIAFLASDYSSYLTGEVISVSSQRA
>NZ_AP022603.1|WP_163742138.1|3396855_3397065_+|hypothetical-protein
MDAGYLSTLSPDADAALLRLPEQARRCVARPQQPARSWTEFNLSRSQALPAAGAAVSGCSSYTGVSRTG
>NZ_AP022603.1|WP_163742141.1|3397048_3397798_-|hypothetical-protein
MSKPWQTHGGGGSGSGADPFGGGGFGGPDPFGGGWGAPPAAPPPAPAPAPPVRPASARPAPARPAPASGARLPERVFAANLLLGGIAAVLVSTAALTLLALPEFRYQYREFGALTPTAVTLAAGLGGWAVAMLALVVGNRRGHRAARLLSVLNSAALIVASGVALVLRPGAQVGWFGALIWVIGPLLILAAVAAAVLLWPGIGRPSLPPPAARGDDAEATVVLRPAATPPRPAGPPPPTARPGDFNPFG
>NZ_AP022603.1|WP_085096665.1|3397799_3399947_-|hypothetical-protein
MPKLISSRIISALLVAALCLLGIAPAPMAVAAPSAIAATLPALDPAAGPATGTPEGYYYQGVDPTLATLTKGSEQLSQKYLIDHDIYDLDLKTLTPGTLEHFLKRWTMYKGKWSFERWRDAYITIIENQRKGMAFEKFVFEKFGLDPTQWRTNARLPAELLEKSRPYDITNTYDKGGEVSIPPVGDRVVFELKSGSTLNSHARAQFKKNLVDLAKAGSELVLIFGSEPTPETVAWIKKALEGYSGPPVTVRYLLTVGVPESTQPTGSTINSEAIAESFDNPQDQAEFEQVSTDILGDIEGEQGGPNPVENPTPQPGGTPAGDLGGIDFTSLELRYVTDSVNGNPVNRYAFRTGSLPDGAPSFGGRRNAAMATDALNVWLALSPEKFWVNLHPYEPDRIIDPAFGRTQAGQVLLEADLEMKEASGRMQRSDTELGRKFMEVLQGENKCFLGRRQWIEPLPASIHEDGDQLYILEIPLTVQLGKEDSDVSPGQSCPDQDPAITTSNGELYEKMIMPAVVQSVNHDPEFADLRRVYASRVAAEWYRKRNAIKPNQYAKQIDSGNVDKWTTDWDQREVFDRFVTSFNNAKPIFTWQTKVGDVTWTHNKAWGGVDFFKVELNDVGAEKFAQDYPELTAVARAPLAGTTAVQDQIWLGGATVVGDPAQLWPMQVTPWTPFRIPTPAPQRVLFYLAILTPVAVWGAVGGTLIWRRRRAGRGI
>NZ_AP022603.1|WP_085096662.1|3400011_3401010_-|hypothetical-protein
MTRDDLAADWAGGISPALTGLADDRGPDATPLDFAAATLTELLADLRLAYDTPAEAIHPDQRPDLLAIAGYLGETLLQVCSGRWDWDDEPGFAERGRPQITDPAVLAALTEGYWGWDANPAGTPPGIPVLAPDPVLGIAAISPLHLVLSALSDRGGDPWRSRYDELAAAVSDYAAAHPDWAPEQTETPGVGDCYGIPGPSPILNAWLAKWDNEFHSWAERYPGDWDFGGESLDRLDDLVAAHATGPQDLDAPQNRFLIEGAVWYLGEAQRRGGRPSRWVYRDWRDMPTDSDLAHFELQSSDNAAVSLPYIILSSAAEDQDRKSRRKFDRWRS
>NZ_AP022603.1|WP_085096799.1|3401193_3401841_+|DUF4190-domain-containing-protein
MPPVNYGMPPAAPFGDPGAPYGAPGYPGAPVPPPTGEVNTLATLSVVFAFVFAPVGAVLGHLALSQIKKRNQAGRNRAILGTTLSYVIILLAIVALVIWLLLGDDDGGSATTTTTATTTSAQTSITSTVITASPKTRPTVKVEELQVGDCVEIQQLRPDPDKPTADEIHIYRAKCEIRDGVFQVRQMTGDKSQCPANYLFNKAETLFACYVKFEQ
>NZ_AP022603.1|WP_085096659.1|3401914_3402565_+|DUF4190-domain-containing-protein
MTYGGDPFGQQFGDPFSPASSGPPPTSGGYGAPGFPPPGQQPPLNTFAVLAPIFGVLIPPAGVAFGHLALPQIKRTGQRGHLSAVAGLVLGYLLTVALVVGLILFALLGGDDDDATVTPTTTAAATPAPTKTVTSMAPPPTRKRDKINLEAATVGMCVEIQSRDTGADALDLFEVECEQRDGVYTVVKRVAASSDCNTTYAAAPPNRAFAVCLNKY
>NZ_AP022603.1|WP_085096656.1|3402583_3403153_+|hypothetical-protein
MPPSNPFDFSDFGGRPQAPPTGPPSGGFGPPSGGFGPPSSPSGFTLPPQAPQQQGPAGGFDPFFGESGAPVGGEEAFGGPSAPMGPLTVSGPPIRLMAAALGIAVLGVLLGLVSVLLGSVLVALLGWLLAGPVAIGALAWFGAADTRRRTSSVYSAPAWLAKANWVVLGFSAIGIALSAWQIALWAGRL

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Crispr_ID: NZ_AP022603_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022603_15

3783001-3783087

Orphan

Consensus_repeat	Method
CGGAACTACACCGCTCGTCGAACCGGCCGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022603_15

>merge|NZ_AP022603|15|3783001-3783087|CRISPRCasFinder
CGGAACTACACCGCTCGTCGAACCGGCCGGTGTTGGTGCGGCCGGTCTCTTCCTCGCGGAACTACACCGCTCGTCGAACCGGCCGGT

>NZ_AP022603|15|13|3783001-3783087|CRISPRCasFinder
CGGAACTACACCGCTCGTCGAACCGGCCGGT	GTTGGTGCGGCCGGTCTCTTCCTCG
CGGAACTACACCGCTCGTCGAACCGGCCGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022603.1\|WP_085099017.1\|3781545_3783000_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_AP022603.1\|WP_163742577.1\|3793249_3794461_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085099023.1\|3783770_3785336_+\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234854
NZ_AP022603.1\|WP_085099029.1\|3788202_3789594_+\|sigma-54-interacting-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224160
NZ_AP022603.1\|WP_085098996.1\|3773799_3774816_-\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NZ_AP022603.1\|WP_085099038.1\|3792556_3792979_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085099035.1\|3791557_3792412_-\|3-hydroxyacyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|181359
NZ_AP022603.1\|WP_085099005.1\|3777267_3778803_+\|acetyl-CoA-acetyltransferase	unknown	unknown	gnl\|CDD\|236204
NZ_AP022603.1\|WP_085099032.1\|3789586_3791548_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|227204
NZ_AP022603.1\|WP_085099020.1\|3783132_3783774_+\|phosphoribosylglycinamide-formyltransferase	unknown	unknown	gnl\|CDD\|235544
NZ_AP022603.1\|WP_085099002.1\|3776267_3777170_+\|succinate--CoA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|180194
NZ_AP022603.1\|WP_133055175.1\|3772509_3773154_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370723
NZ_AP022603.1\|WP_085099160.1\|3785409_3786282_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226304
NZ_AP022603.1\|WP_163742575.1\|3786558_3787986_+\|toll/interleukin-1-receptor-domain-containing-protein	unknown	unknown	gnl\|CDD\|379328
NZ_AP022603.1\|WP_085098999.1\|3775088_3776252_+\|ADP-forming-succinate--CoA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234813
NZ_AP022603.1\|WP_085099014.1\|3780649_3781522_+\|DUF5336-domain-containing-protein	unknown	unknown	gnl\|CDD\|375092
NZ_AP022603.1\|WP_085099157.1\|3773163_3773658_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_133055176.1\|3779671_3780511_+\|sensor-domain-containing-protein	unknown	unknown	gnl\|CDD\|372884
NZ_AP022603.1\|WP_109750587.1\|3778817_3779675_+\|sensor-domain-containing-protein	unknown	unknown	gnl\|CDD\|372884
NZ_AP022603.1\|WP_085099043.1\|3794519_3795113_-\|DUF1707-and-DUF2154-domain-containing-protein	unknown	unknown	gnl\|CDD\|377959

Protein	Function_ID	Function_description	E-value
NZ_AP022603.1\|WP_085099017.1\|3781545_3783000_+\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0.00184749
NZ_AP022603.1\|WP_085099020.1\|3783132_3783774_+\|phosphoribosylglycinamide-formyltransferase	gnl\|CDD\|235544	PRK05647, purN, phosphoribosylglycinamide formyltransferase; Reviewed.	8.20453e-99
NZ_AP022603.1\|WP_085099029.1\|3788202_3789594_+\|sigma-54-interacting-transcriptional-regulator	gnl\|CDD\|224160	COG1239, ChlI, Mg-chelatase subunit ChlI [Coenzyme metabolism].	1.15176e-105
NZ_AP022603.1\|WP_085098996.1\|3773799_3774816_-\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	8.28916e-41
NZ_AP022603.1\|WP_085099035.1\|3791557_3792412_-\|3-hydroxyacyl-CoA-dehydrogenase	gnl\|CDD\|181359	PRK08293, PRK08293, 3-hydroxyacyl-CoA dehydrogenase.	1.51265e-149
NZ_AP022603.1\|WP_085099005.1\|3777267_3778803_+\|acetyl-CoA-acetyltransferase	gnl\|CDD\|236204	PRK08257, PRK08257, acetyl-CoA acetyltransferase; Validated.	0
NZ_AP022603.1\|WP_085099032.1\|3789586_3791548_+\|VWA-domain-containing-protein	gnl\|CDD\|227204	COG4867, COG4867, Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only].	0
NZ_AP022603.1\|WP_085099023.1\|3783770_3785336_+\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	gnl\|CDD\|234854	PRK00881, purH, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional.	0
NZ_AP022603.1\|WP_085099002.1\|3776267_3777170_+\|succinate--CoA-ligase-subunit-alpha	gnl\|CDD\|180194	PRK05678, PRK05678, succinyl-CoA synthetase subunit alpha; Validated.	0
NZ_AP022603.1\|WP_133055175.1\|3772509_3773154_-\|hypothetical-protein	gnl\|CDD\|370723	pfam09849, DUF2076, Uncharacterized protein conserved in bacteria (DUF2076). This domain, found in various hypothetical prokaryotic proteins, has no known function. The domain, however, is found in various periplasmic ligand-binding sensor proteins.	0.000958119
NZ_AP022603.1\|WP_085099160.1\|3785409_3786282_+\|hypothetical-protein	gnl\|CDD\|226304	COG3781, COG3781, Predicted membrane protein [Function unknown].	1.23555e-41
NZ_AP022603.1\|WP_163742575.1\|3786558_3787986_+\|toll/interleukin-1-receptor-domain-containing-protein	gnl\|CDD\|379328	pfam13676, TIR_2, TIR domain. This is a family of bacterial Toll-like receptors.	1.76198e-22
NZ_AP022603.1\|WP_085098999.1\|3775088_3776252_+\|ADP-forming-succinate--CoA-ligase-subunit-beta	gnl\|CDD\|234813	PRK00696, sucC, ADP-forming succinate--CoA ligase subunit beta.	0
NZ_AP022603.1\|WP_085099014.1\|3780649_3781522_+\|DUF5336-domain-containing-protein	gnl\|CDD\|375092	pfam17270, DUF5336, Family of unknown function (DUF5336). This Actinobacterial family of proteins has no known function. Most of the family members are predicted to have have 4 trans-membrane regions.	4.57354e-35
NZ_AP022603.1\|WP_133055176.1\|3779671_3780511_+\|sensor-domain-containing-protein	gnl\|CDD\|372884	pfam14032, PknH_C, PknH-like extracellular domain. This domain is functionally uncharacterized. It is found as the periplasmic domain of the bacterial protein kinase PknH. The domain is also found in isolation in numerous proteins, for example the lipoproteins lpqQ, lprH, lppH and lpqA from M. tuberculosis. This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 268 amino acids in length. There are two completely conserved C residues that are likely to form a disulphide bond. A second pair of cysteines are less well conserved probably form a second disulphide bond. It seems likely that this domain functions to bind some as yet unknown ligand.	4.47126e-21
NZ_AP022603.1\|WP_109750587.1\|3778817_3779675_+\|sensor-domain-containing-protein	gnl\|CDD\|372884	pfam14032, PknH_C, PknH-like extracellular domain. This domain is functionally uncharacterized. It is found as the periplasmic domain of the bacterial protein kinase PknH. The domain is also found in isolation in numerous proteins, for example the lipoproteins lpqQ, lprH, lppH and lpqA from M. tuberculosis. This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 268 amino acids in length. There are two completely conserved C residues that are likely to form a disulphide bond. A second pair of cysteines are less well conserved probably form a second disulphide bond. It seems likely that this domain functions to bind some as yet unknown ligand.	2.47351e-24
NZ_AP022603.1\|WP_085099043.1\|3794519_3795113_-\|DUF1707-and-DUF2154-domain-containing-protein	gnl\|CDD\|377959	pfam08044, DUF1707, Domain of unknown function (DUF1707). This domain is found in a variety of Actinomycetales proteins. All of the proteins containing this domain are hypothetical and probably membrane bound or associated. Currently, it is unclear to the function of this domain.	1.20232e-16

>NZ_AP022603.1|WP_085099017.1|3781545_3783000_+|hypothetical-protein
MEDNRAVGARQARDLVRVAFAPALVALVIIAAVVLLQLLIANSDMTGAFGAIASIWLGVHQVPISIGGQTLGVLPLLPAALMVWGTARTTAAATAPNSSWFVTRWVVACALGGPLLIAALALAVVHDASSVLSQLQTPDSLNAFTSVLAVHGIGAVLGVGSKLERRRLLAGTRLPHWTFDALRAALAGVLALFGLSAALTALSLVVHWGSMHDLFGITDSMFGQLSLALLSVLYAPNVILGMSAIAVGSSANIGFATFSAFTVYGGDIPALPVLAAAPTPPLGPIWVAWLIIGAASAVAVGQQCARRPLPIGPAAAKLATASALGALAMALLGYAGSGELGNFGFVGVDQATFGPAVFCWFFGIGALTVAMAGGLTRAPKPVVAPAADDGPDASGEPDEDERAEGERAEGEPEPGPEFAEQRADDADSAAWSSPVTEPIAVPPGEPPGEPAPAEQASDQGPGLRLGPHDDLPDAEDLFDVDGDH
>NZ_AP022603.1|WP_085099014.1|3780649_3781522_+|DUF5336-domain-containing-protein
MTYSPGGPGGYQPPQPPSYGAPTSGSFAAQGQAPAAAGESQLPFYLKIAVAALGVLAYLASFGPTLVYSSESLGSSKGTDMWLVLFALIAALVAGVSLLPKARDTAAPVAVLSLTAVFMVISEVVNKSDLYSYGWAIWIVLLLVIGQAAAAVMVLLYSAGVLTPPVPQPRQPEPSQYGSYGAPAPGYYGQQPGAEQRPGYPSQYGGYTPPSAPGSFGAPGQQPQQPPQPTQGGQHGTPTPPTGFPSFSPPPAVGSGESAAAPTTQIQPGQPYQPGQQPEQPSGPGQPPTA
>NZ_AP022603.1|WP_133055176.1|3779671_3780511_+|sensor-domain-containing-protein
MMSAPGGDFWNSLPSGGAPAPGPGNPAPAEQPRAGRRGPIIAGLAVLAAVALIAVLAVSGVADRVLAGRAVAAEAPATTSVAAPPPPPAITAEGLPALLSGPEQVGDIIVATGMKVRQVYDKPDDIDAGTTYNPLECASALYSGMPPALSDTGFQAAYQTSMEQTGLEAGLSADQGVFLYPTAADAQRALDGYLALWQRCAGTMTVSWGGPTLTVDVVAPARTDDGISTLDNSGREAAFAVNRAIAVKGPVLVDCQVIGTTPQSTAAELARQILARIPA
>NZ_AP022603.1|WP_109750587.1|3778817_3779675_+|sensor-domain-containing-protein
MTAGDFWDRAGTGAAPPAAPGPRAGGGPGEGPGGGGGRLIAAVVGSVLAALLVTALVIAGVSGKTVDGRAVADGQPATTTTATTATTSATPMPRALTVDGLPSLLSPPDQVARLVGVPSMRVGHRVQDLDEPNPGQSFSPAECIGARFSGMAAALGSSGQLGFYELRTKDDDSGAILVDQGALLYPSPAAAADALENYRALWRRCAGTVNTTESGRDYTIDVGPIVDAGDGISTLTTTAGVGDRFGQRGIAAKGPVLVDCQFLADQQPSADVAAVVRAILARIPA
>NZ_AP022603.1|WP_085099005.1|3777267_3778803_+|acetyl-CoA-acetyltransferase
MALDPRTPVVVGVGQFTERIDDDGYRARSSVELATEAVRAALADTGADPGVVAAAADTFAGLRQFEICIPAPPPLGASDNYVRSVAGRVGADPARAVLEQIGGNGPQQLLTEFAGRIAAGDAEVVVLLGSENGSTLRYFAGREDKPDFTEQVGGQLEDRGYGYEYYMTEYTVAHGLTGAPVQYGLLDNARRARLGLGVADYRTAMAELFAPLSEVAAKNPYSSSPTVRSVAEIAAVGDGNRMIADPYPRLLVARDQVNQGSAVVVMSVAAARRLGVPESRWVYLHGHADLMEQPFLDRENLDVSHAATAAVTEALAVAGIGLDEVATFDLYSCFPFPVFAVCDGVGLAPDDPRGLTLTGGLPYFGGPGNSYSLHAIAETVVEMRSRPGQYGLVGANGGIMSKYSVGVYSSTPAPWRPDGSAALQARIDARPRVAGTRDVDGPGTIETYSVRYDWPVRTGIIVGRRDADGSRFLAVTTDDELVALMSDGDPLGARIQLRCSDGINRAAALPR
>NZ_AP022603.1|WP_085099002.1|3776267_3777170_+|succinate--CoA-ligase-subunit-alpha
MSVFLNKDSKVIVQGITGGEGTKHTALMLKAGTQVVGGVNARKAGTTVSHVDKDGNGVELPVFASVAEAMEKTGADVSIAFVPPAFSKDAIVEAIDAEIPLLVVITEGIPVQDTAYAWAYNVDKGAKTRIIGPNCPGVITPGEALVGITPNNITGKGPIGLVSKSGTLTYQMMYELRDLGFSTAIGIGGDPVIGTTHIDAIEAFEKDPETKVIVMIGEIGGDAEERAADYIKANVTKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAQAKKEALEAAGVKVGKTPSETAKLAREIFEKL
>NZ_AP022603.1|WP_085098999.1|3775088_3776252_+|ADP-forming-succinate--CoA-ligase-subunit-beta
MDLFEYQAKELFAKHNVPTTPGRVTESADDAKAIAEEIGKPVMIKAQVKVGGRGKAGGVKYAATPDDALTHATNILGLDIKGHVVKRLLVAEASDIAEEYYISFLLDRANRTYLAMCSVEGGMEIEEVAATKPDRLAKVAVDPIAGVDVAFARSIAEQGHLPAEVLDAAAVTIAKLWDVFVAEDATLVEVNPLVRTPDDQILALDGKVTLDENASFRHADHEAFVDRDATDPLELKAKENDLNYVKLDGQVGIIGNGAGLVMSTLDVVAYAGENHGGVKPANFLDIGGGASAEVMAAGLDVILGDSQVKSVFVNVFGGITSCDAVANGIVKALEILGDEANKPLVVRLDGNNVEAGRKILADANHPLVIQAETMDAGADKAAELANK
>NZ_AP022603.1|WP_085098996.1|3773799_3774816_-|M23-family-metallopeptidase
MPQQRSSGAPSSGAPQDSRRPSSRRPGPAEVTDITPFNEFGALADLDFRHCAFDAGAVVLDAPELDDLADTDNLVAIRLERRSDLPERFETADEITEVMPRLGQHRKVETGPVKGRVLVAAMAAGAAAAAAYTALTPRQASEVTNTVVAADPASHSEGATITGTSKGMQLVAMTPALNVTGHNEELAKGAAFAQERAEREARLARPLFVQPTQGIFTSGYGYRWGALHGGIDIAAPIGTPIYAVSDGVVIEAGPAAGYGALVKIRHSDGTVTLYGHINTWVVSIGQQVMAGDQIATVGNRGNSTGPHCHFEVMPGGGSRIDPVPWLAARGVSVGSYVG
>NZ_AP022603.1|WP_085099157.1|3773163_3773658_-|hypothetical-protein
MIRRFPTGAIPVANTPPTGIDAPTGIIAVAPAQPEPGSLTAQAAVVTAILGGWAAAVVSTNLVTGWWATDRLFCLAIGFLALVLGAASIAGVLLTLRRRAWGPYLLTAGAVVALLTFCGVFIAGARLAGIVYAMPLLPLATLILALLPSTRRWTSPSPRAQSTG
>NZ_AP022603.1|WP_133055175.1|3772509_3773154_-|hypothetical-protein
MNPYPPPGNPYQQQPYQQGYGAPQPGYGAGYGAPQSGYGAPYAQPGATPYGAAPYGAPGYPVAGTNNTTAVIAAILAFLTSATCLWGAFGALLGGALTSSTIYGVDIFPGWFTATMLIVGLANLALGALLITGGVFTLKRKRKGPALVAVGAGGTIVFSIVSLVATIAMANELVGDYGLVSSAGSHVVTAMQLMLPIATLVLALVAPTRRHCAL
>NZ_AP022603.1|WP_085099020.1|3783132_3783774_+|phosphoribosylglycinamide-formyltransferase
MPESLRVPSSEPARLVVLASGTGSLLQALLEAAVGDYPARVVAVGVDRDCRAAEIAAAAGVPVFDVRLRAHPDRAAWDGALAAAAADYAPDLVVSAGFMKILGPDFLSRFPGRIINTHPALLPAFPGAHAVPDALAYGATVTGTTVHVVDDGVDTGPILAQCAVPVFDGDDVDALHERIKTEERRLLVDVLAAVVTRGVSWDGRRARFGGEGQ
>NZ_AP022603.1|WP_085099023.1|3783770_3785336_+|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase
MTAKRPIRRALISVYDKTGLVELARGLHDAGVTLVSTGSTAKNIADQGIPVTPVEDVTGFPEVLDGRVKTLHPKVHAGLLADTRKPEHVAALAELGIEAFDLVVVNLYPFTQTVESGASEDDCVEQIDIGGPSMVRAAAKNHPSVAVVVDPLGYDGVLAAVRAGGFTLDERKRLASLAFRHTAEYDVAVASWMGATLSAEGDGNNALPQWFGGVWRRSAVLRYGENPHQQAALYTDNAGWPGLAQAQQLHGKEMSYNNFTDADAAWRAAFDHEETCVAIIKHANPCGIAVSAVSVADAHRKAHDCDPLSAFGGVIATNTTVSVEMARTVADIFTEVIVAPAYEPGAVEVLSGKKNIRILVAAEPMPGGAEFRQVSGGLLVQTRDVLDADGDDPNNWTLATGEPADPATLADLVFAWRTCRAVKSNAIVIAADGATVGVGMGQVNRVDAARLAVERAGERTRGAVAASDAFFPFPDGLQTLTAAGVKAIVHPGGSMRDDQVTEAAANAGITLYLTGARHFAH
>NZ_AP022603.1|WP_085099160.1|3785409_3786282_+|hypothetical-protein
MRRTWDEAVWILLACAAAYFGDRYLLDDHFELPAVVPPLLGTALAFFIGFSNAQAYGRWWEARTIWGAIVNESRSWARECIYYVRDDEELGIARRLTYRHIAFVYALKAYLRDEPPGSCDEVFRRYLDEPERAQLQGKQNKHNALLDWQSRDLQQLCDEGRIDGYRFLQLDRRITNLCDEMGKSERIRNTVFPPTYNYYTQMFVWVFIVSVTIVLVNGVGAYGILPAFVLGYVFVVTQGIGLRLLNPFEHLMSGTPLDQISRGIEITLLEMLGETDLPEPVRSVDGMYVT
>NZ_AP022603.1|WP_163742575.1|3786558_3787986_+|toll/interleukin-1-receptor-domain-containing-protein
MAVFISYSSRDAQIVGELSAALRRAHHDLWIDDQLRGGDAWWRAILAQIRDCDVVLAALSQNMLASKACQAELRYAQALGKPILPVQVGPLTSVRTNPLAGMQMIDFQDRSIDAWMALDEAVRAKRSAPPPLPDPLPSEPQMPFGYLMRLGGQIGEPDLTAQQQLLIVAELKAALEEDGDDDGARQDIRELLAQLRDRGDVTFRTRSEIDALLSGAGASVATPLPAEPASAPPSAAPKSRRPLVFAAVAAAAVIAVVAAVVLLSGGDPAPTAAPGRAGPTQSAAAEPAAEPAGDVVVGDPAVGDTACARADAPLALIATDANEPVLRIPRPAGWEPNEWMASDGIFRYALYNNALMQDGIAPSALVALDEERGRTDPNSIFLLKRGALSAIGATDVTVESHTVCGLPAETVRYRTAAIAGLASHPATALFVALQTADRTYTATLTLEAVDSDNPTFQQDSANMLTGFQMLPPAGS
>NZ_AP022603.1|WP_085099029.1|3788202_3789594_+|sigma-54-interacting-transcriptional-regulator
MSTPNNLPRTVGELRASGHQEKGVKSEIRDNLLAALAAGSTAENIWPGIHGFEDSVLPQLERALIAGHDVVLLGERGQGKTRLLRSLTNLLDEWTPVIAGSELGEHPYSPITPESIRRCAESGDDLPIEWRHRSARYTEKLATPDTSVADLVGDIDPIKVAEGRSLGDPETIAYGLIPRAHRGIVAVNELPDLAERIQVAMLNVMEERDIQVRGYTLRLPLDVLVVASANPEDYTNRGRIITPLKDRFGAEIRTHYPRELDAEVGVIAQEAHLSAEVPGYLLQIIARFARLLRESTSVDQRSGVSARFAIAAAETAAASARHRGAILGEPDPVARVVDLPGIIDVLRGKLEFESGEEGREQAVLEHLLRRATADTAARVLGGLDVAPLVTEIEAGHPVTTGERVGAKDLLASLPEVPVLDQIAERVGAVSDGQRAAAAELALEALYLAKRIDKTTGEGETVYG
>NZ_AP022603.1|WP_085099032.1|3789586_3791548_+|VWA-domain-containing-protein
MARVRYSRYTGGPDPLAPPIDLRDALESIGEDVMAGASPRRALSELLRRGMPGLKGTDGLAAAANRKRRELLRDHNLDGTLAEVKRLLDEAVLAERKELARALDDDARFSELQLGSLPSSPAKAVAELSGYDWRSAQAREKYRQIKDLMGAELLGQRFEGMKEALAGATDEDRRAVKEMLDDLNALLDKHANGEASQQDFDAFMAKHGQHFPENPSNIEELLDSLARRAAAAQRFRNSLSPEQRAELDALAQQAFGSPDLMDALGRLDDHLQAARPGEDWTGEQRFSGNDPLGMSEATQVMADIGELEDLAEQLSQEYAGASMDDVDLDALARQLGEEAAINARTLADLEKALMDQGFLDRSSDGSWRLSPKAMRQLGKAALRDVAERLSGRHGERNTRRAGAAGELTGATRSWEFGDTEPWNVTRTLTNAVLRSAGSPADGPLRITVEDVEVSETETRTQAAVALLVDTSFSMVMEDRWLPMKRTALALNHLISTRFRSDELQIIAFGRQARTLSAAELTGLEAVYEQGTNLHHALLLALRHLRRHPNAQPVVLVVTDGEPTAHLEDFGDGAESFFGYPPHPRTIGLTVRAFDEVARLGAQITIFRLGDDPGLARFIDQMARRVGGRVIDPDLDGLGAAVVGDYLNARRRRR
>NZ_AP022603.1|WP_085099035.1|3791557_3792412_-|3-hydroxyacyl-CoA-dehydrogenase
MTAEIRTVTILGCGVLGAQIAFQSALKGFPVTAYDINDEALAAARVRFDKLAATYLKSVAGVDEAATKAALGRLTLTSDLSAAAASDLVIEAVPEVLTLKEDIYRKLGELAPAATIFATNSSTLLPSDLKDSTGRPDRFLALHFANMIWLHNTAEVMGSADTDPAVHAAVVAFATAIGMVPIELHKEKSGYVLNSLLVPLLRAGLELVAGGYAEPGDVDQTWRIGTGAPAGPCQIWDVVGMRTGYNIMSHGDEEEQRLAVWLKQNYIDKGKLGLESGEGFYKYV
>NZ_AP022603.1|WP_085099038.1|3792556_3792979_-|hypothetical-protein
MVIPWIEQRTVMRLTLRDGLVLDFEDNNELVIVGPIRLTLPPVGPYPEEQIGIDPRHVAVAEIPLLNLSGAVCTAAACTDDGRLHLEFSRGHRIDVEPTDDTTSWELYGRRHGYLACLPHGRLRVLRHDLPDDQGHPAAS
>NZ_AP022603.1|WP_163742577.1|3793249_3794461_+|hypothetical-protein
MLAPRSQAVEVAGAGTSVRALDLDYRLTALSDITVEQLSAALLSGREFDLDFEQKSYVSNGTTYYYFVDKYDNEWAFSDDSDAVPAISGISAVVYHLADSILPDGFHGDDYLFGQGQTQALRVSLYQLSGAAPDSPEGQLIDFITDPLGTIRYLVASGVEEALPGIGEDLVNYPQAMIQLLVASGVDTALPGAGDFVLDPMGTAFRTSVRLAGDAAKAGTGNDDADDFVENIFLNVLTKVGPGQQPAPPAPEETEPEGTGGGDAGTRTDGTDGVLASRSAFSGDQSGTETGSSDDVTSSKTLREKLSQPATGFTGQLSQARTASRTKLAAAEQRINDRVTEARNTIDAGVKRAGAKLSKIANDGLKQIERSVQQVKDTAAKAAPKKVASEKAAPKKDDQAKTE
>NZ_AP022603.1|WP_085099043.1|3794519_3795113_-|DUF1707-and-DUF2154-domain-containing-protein
MTEPAPRTATSRAADTDRVQVAQLLTDAAAEGLLELDDYERRLAQAYSATTYAELDRLSADLPGIANTRRGACQPAPKTTLLAFMSGFERRGRWNVPRKLTMFSFWGSGVIDLRYADFTSPDVEIKAYSIMGGQTILLPPEVNLSVDGTSVMGSFEEETSGAGTPGAPVVTVKGFSLWGGVNVRRKKRRPNRHVQRD

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Crispr_ID: NZ_AP022603_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022603_16

3822412-3822510

Orphan

Consensus_repeat	Method
CCGGCCAGCGCTCAGCTGGGTACACG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022603_16

>merge|NZ_AP022603|16|3822412-3822510|CRISPRCasFinder
CCGGCCAGCGCTCAGCTGGGTACACGCGCCTCGGCGTGTCGTGTACGAGGGTGAGCGGTCGCGGCGGGACTCTCCGGCCAGCGCTCAGCTGTGTACACG

>NZ_AP022603|16|14|3822412-3822510|CRISPRCasFinder
CCGGCCAGCGCTCAGCTGGGTACACG	CGCCTCGGCGTGTCGTGTACGAGGGTGAGCGGTCGCGGCGGGACTCT
CCGGCCAGCGCTCAGCTGTGTACACG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022603.1\|WP_085095863.1\|3826587_3827274_-\|LpqN/LpqT-family-lipoprotein	unknown	unknown	gnl\|CDD\|378485
NZ_AP022603.1\|WP_085099109.1\|3819069_3820317_+\|molybdopterin-molybdotransferase-MoeA	unknown	unknown	gnl\|CDD\|238452
NZ_AP022603.1\|WP_085099090.1\|3815299_3815962_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274472
NZ_AP022603.1\|WP_085095861.1\|3825764_3826583_+\|shikimate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|183587
NZ_AP022603.1\|WP_085095872.1\|3829404_3830721_+\|arginine-deiminase	unknown	unknown	gnl\|CDD\|234949
NZ_AP022603.1\|WP_085099102.1\|3817438_3818035_-\|5-formyltetrahydrofolate-cyclo-ligase	unknown	unknown	gnl\|CDD\|274270
NZ_AP022603.1\|WP_109750501.1\|3828832_3829429_-\|alpha-ketoglutarate-dependent-dioxygenase-AlkB	unknown	unknown	gnl\|CDD\|225687
NZ_AP022603.1\|WP_085095859.1\|3824746_3825733_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|237999
NZ_AP022603.1\|WP_085099112.1\|3821169_3822219_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|349949
NZ_AP022603.1\|WP_085099087.1\|3814717_3815170_-\|large-conductance-mechanosensitive-channel-protein-MscL	unknown	unknown	gnl\|CDD\|234795
NZ_AP022603.1\|WP_085099093.1\|3816141_3816504_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085099099.1\|3817024_3817375_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_133055137.1\|3822795_3823755_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085095868.1\|3827474_3828155_+\|DUF5642-family-protein	unknown	unknown	gnl\|CDD\|376126
NZ_AP022603.1\|WP_085095855.1\|3823757_3824462_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085099169.1\|3820365_3820977_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_AP022603.1\|WP_085095857.1\|3824471_3824687_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085099106.1\|3818096_3819008_+\|UTP--glucose-1-phosphate-uridylyltransferase	unknown	unknown	gnl\|CDD\|224131
NZ_AP022603.1\|WP_085095870.1\|3828161_3828836_+\|DUF5642-family-protein	unknown	unknown	gnl\|CDD\|376126
NZ_AP022603.1\|WP_085099096.1\|3816514_3816826_-\|FmdB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225210

Protein	Function_ID	Function_description	E-value
NZ_AP022603.1\|WP_085099106.1\|3818096_3819008_+\|UTP--glucose-1-phosphate-uridylyltransferase	gnl\|CDD\|224131	COG1210, GalU, UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane].	2.11293e-131
NZ_AP022603.1\|WP_085099109.1\|3819069_3820317_+\|molybdopterin-molybdotransferase-MoeA	gnl\|CDD\|238452	cd00887, MoeA, MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.	9.44749e-130
NZ_AP022603.1\|WP_085099090.1\|3815299_3815962_-\|hypothetical-protein	gnl\|CDD\|274472	TIGR03177, pilus_cpaB, Flp pilus assembly protein CpaB. Members of this protein family are the CpaB protein of Flp-type pilus assembly. Similar proteins include the FlgA protein of bacterial flagellum biosynthesis.	9.82957e-09
NZ_AP022603.1\|WP_085095872.1\|3829404_3830721_+\|arginine-deiminase	gnl\|CDD\|234949	PRK01388, PRK01388, arginine deiminase; Provisional.	0
NZ_AP022603.1\|WP_085099102.1\|3817438_3818035_-\|5-formyltetrahydrofolate-cyclo-ligase	gnl\|CDD\|274270	TIGR02727, Uncharacterized_protein_YqgN, 5,10-methenyltetrahydrofolate synthetase. This enzyme, 5,10-methenyltetrahydrofolate synthetase, is also called 5-formyltetrahydrofolate cycloligase. Function of bacterial proteins in this family was inferred originally from the known activity of eukaryotic homologs. Recently, activity was shown explicitly for the member from Mycoplasma pneumonia. Members of this family from alpha- and gamma-proteobacteria, designated ygfA, are often found in an operon with 6S structural RNA, and show a similar pattern of high expression during stationary phase. The function may be to deplete folate to slow 1-carbon biosynthetic metabolism. [Central intermediary metabolism, One-carbon metabolism].	2.16466e-47
NZ_AP022603.1\|WP_109750501.1\|3828832_3829429_-\|alpha-ketoglutarate-dependent-dioxygenase-AlkB	gnl\|CDD\|225687	COG3145, AlkB, Alkylated DNA repair protein [DNA replication, recombination, and repair].	7.08322e-38
NZ_AP022603.1\|WP_085095859.1\|3824746_3825733_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|237999	cd00038, CAP_ED, effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels.	4.68173e-22
NZ_AP022603.1\|WP_085099112.1\|3821169_3822219_+\|hypothetical-protein	gnl\|CDD\|349949	cd06174, MFS, Major Facilitator Superfamily. The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.	0.000765874
NZ_AP022603.1\|WP_085099087.1\|3814717_3815170_-\|large-conductance-mechanosensitive-channel-protein-MscL	gnl\|CDD\|234795	PRK00567, mscL, large-conductance mechanosensitive channel protein MscL.	1.34106e-46
NZ_AP022603.1\|WP_085095868.1\|3827474_3828155_+\|DUF5642-family-protein	gnl\|CDD\|376126	pfam18702, DUF5642, Domain of unknown function (DUF5642). This is a domain of unknown function found in actinobacteria.	2.94704e-42
NZ_AP022603.1\|WP_085095861.1\|3825764_3826583_+\|shikimate-5-dehydrogenase	gnl\|CDD\|183587	PRK12550, PRK12550, shikimate 5-dehydrogenase; Reviewed.	4.53126e-169
NZ_AP022603.1\|WP_085099169.1\|3820365_3820977_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	3.76095e-31
NZ_AP022603.1\|WP_085095863.1\|3826587_3827274_-\|LpqN/LpqT-family-lipoprotein	gnl\|CDD\|378485	pfam10738, Lpp-LpqN, Probable lipoprotein LpqN. This family is conserved in Mycobacteriaceae and is likely to be a lipoprotein.	4.93336e-29
NZ_AP022603.1\|WP_085095870.1\|3828161_3828836_+\|DUF5642-family-protein	gnl\|CDD\|376126	pfam18702, DUF5642, Domain of unknown function (DUF5642). This is a domain of unknown function found in actinobacteria.	2.55444e-67
NZ_AP022603.1\|WP_085099096.1\|3816514_3816826_-\|FmdB-family-transcriptional-regulator	gnl\|CDD\|225210	COG2331, COG2331, Uncharacterized protein conserved in bacteria [Function unknown].	5.57414e-27

>NZ_AP022603.1|WP_085099112.1|3821169_3822219_+|hypothetical-protein
MPSIPQSLLWISLVVLWLFVLVPMLINKRDNVRRTSDVALATRVLNVKASRLLRRRGPAHGHRSDPDWQPEADLDDEYDDYDEDATGPVVVTARVTQVHSVVVMNETVVAEEEDYLDVDIVDEDSGALPVGRITEAVTGPIEVVTEAPQAPVGQAAVEQDAVEESPAEPVRADESDEMGDDEYQYVEDTSGLEPPAEESRFSRQAPISHGRGYATKTAAAVSARKYRFRSRVLMTMCVLLGISAAAGLALAPVFWWMCAGLAVVTLLYLAYLRRQTRIEERLRRRRMARMARSRLGVENTYDREMDVVPTRLRQPGAVVLEIDDEDPVFEHLEEVAYARHYDLPRAAGQ
>NZ_AP022603.1|WP_085099169.1|3820365_3820977_+|GNAT-family-N-acetyltransferase
MPVGPLRVPAGVLTLRPPRLRDGVAWSRIRNADRDALERWEPSAEPSWEARHATTSWPSLRRSMRSEAQAGRMLPYVIELDGRFCGQLTIGNVAHGALRSAWIGYWVHSEVTGLGVATGAVALGLDHCFGPVGLHRVDATVRPENAASRRVLAKAGFREEGLLRRYLHVDGAWRDHLLVAMTVEECPGSAAARLVRDGRAWWT
>NZ_AP022603.1|WP_085099109.1|3819069_3820317_+|molybdopterin-molybdotransferase-MoeA
MRSVEEQQARVQAAAVAPRPVRVAIAEAQGLMCAEEVVTERPLPGFDQAAIDGYAVRSVDVLGAGDEAEAGGTVSLPVVSAIAAGDRTPSRLQPRQAARIQTGAPMPTLADAVLPLRWTDGGQSRVRVLRGVRSGAYVRRTGDDVQPGDVAVRAGTIIGAAQVGLLAAVGRDRVLVHPRPRLSIMSVGGELVDVSRTPGNGQVYDVNSYALAAAARDAGAEVNRVGIVDSDPVKLREVVEGQLSRAEIVVIAGAVGGAAAEAVRAVLAELGEMEVARIAMHPGSVQGFGQLGRDGVPTFLLPANPVSALVVFEVMVRPLIRMSLGKRQPLRRIVQARAVAPITSVPGRTGYLRGQLMRDQDTGEYLVQALGGAPGSSSHLLATLAEANCLVIVPAATEEVRTGEIVDVAFLAQRG
>NZ_AP022603.1|WP_085099106.1|3818096_3819008_+|UTP--glucose-1-phosphate-uridylyltransferase
MSTPQVPIPRTAIVPAAGLGTRFLPVTKTVPKELLPVVDTPGIELVAAEAAEAGAERLVIVTSEGKDGVVAHFVEDLVLEGTLEARGKHVILEKVRRAPALIKVESVVQAEPLGLGHAVLCVEPKLAPDEDAVAVLLPDDLVLPTGVLETMSKVRARRGGSVLCAIEVAPDEISAYGVFDVEPVPDAANPNVLKVKAMVEKPPADQAPSLYAAAGRYVLDRAIFDALHRVEAGAGGEIQLTDAIALLIAEGHPVHVVVHRGARHDLGNPGGYLKAAVDFALERDDYGPELRRWLIERLGLSDR
>NZ_AP022603.1|WP_085099102.1|3817438_3818035_-|5-formyltetrahydrofolate-cyclo-ligase
MHTEAKSALRRRLLAARRAVGAPQRSAEAAALTAALTAAIAERAPDTVCGYVPVGSEPGSISLLDALDAAGVRVLLPVTVLDDDGGPGPLRWGRYRPAGLVAARYGLREPDGPVLPAEEIGAAQLIVVPALAVDRRGGRLGRGAGFYDRSLPLRAPGTPLIAVVRDEEVLDEVPTGPHDVAMTHLATPGLGVRAVSAP
>NZ_AP022603.1|WP_085099099.1|3817024_3817375_+|hypothetical-protein
MTARIRSRRARTVGIAGIGVLGIAAAALASAAVAVADVNEMAPGPEVHSRQASVSSYQGVRVNSPNVARGQSETRLAGAGVIEAQGEVRDSAKAVPGSTAGAFQGPWPIGAPMGDF
>NZ_AP022603.1|WP_085099096.1|3816514_3816826_-|FmdB-family-transcriptional-regulator
MPTYSYACTDCDDRFDAVQAFSDDALTTCSKCNGRLRKLFGSVGVVFKGSGFYRNDSRTSSSNTGSSGAPKAEKSGDSGSSSSSDSASSKPAAPAPAAAAASS
>NZ_AP022603.1|WP_085099093.1|3816141_3816504_+|hypothetical-protein
MSDHAMGGRRAAAMVGALAVGFAALVLTGQGAAHAATTSPAETGRTHGHHDSEGGGTAGPETTGTPTARQSGGTDAHERVDIRTTQGIVRHGTIAKPGNMALPHTEGRVGAGKICTDGGC
>NZ_AP022603.1|WP_085099090.1|3815299_3815962_-|hypothetical-protein
MTRQPPSPLDPTVTDRIRGLVQPDWLHTTRTRRIAAALLVLLAAAAALRPDPAGQRSPTLIATRDLAPGAALGPDDVRVVYQITGSRPDGALDDPAAVLGATPGGAIRRGEVLTDVRLLGSRLAAAGAGPDARMVPIRLSDGAVADLIRAGDVVDVLAARDDTDGPAPRVLAADAVVVLIPPAPAQAGADGRIVLVALPAAAAQLVATASLTDALTVTMH
>NZ_AP022603.1|WP_085099087.1|3814717_3815170_-|large-conductance-mechanosensitive-channel-protein-MscL
MLKGFKEFISRGNVIDLAVAVVIGTAFTAVVTAFTDSVIQPLISRIGAGPGADYGVLRIPLGGEQFIDFNTVLTSLINFLLVAAVVYFLIVVPFKKLKKDDPAVEEEATELTLLTEIRDLLQSQGSAGNPPAGRHGAAPNADPGGPRHLG
>NZ_AP022603.1|WP_133055137.1|3822795_3823755_+|hypothetical-protein
MTRSGGLLLALGLAAALTGCGTDQEPKEQPTDLLNGVYTVTVQGDKLTNMGRPSPGKSWSRQYAVRTSCADDGCTQLALRLRDDDPTAVFTEPDGTPAEPMVADFVDGSWQLVEQTDWTCSDGSVGLQTVQWSLIPGEDALTGTRIDVRTASPECVVVLEEPVTMTRTGDIDAGIDLPETVDAAPWQPSAPAGLTGSYERVATDSEGAEVDRATVDFRSFCVRNSDDCVALKRFQDVDGPVVVPFLFESGQWSAQFNAGEAECPGSGSPGHQLMYEQYALPEDATTPIQSLTGSELVTVHGGCAGVMRDFDLALQRQEG
>NZ_AP022603.1|WP_085095855.1|3823757_3824462_+|hypothetical-protein
MVTAAGIIRASAGLMLVAGLAGCSPQPADNAPGDDAQTATFDGAYTLELGALQAAGSGSDELGPDPLTMTVMVRSDCRDGCVASATVVDPPPELSLPEVRLDYTGKHWLGVSINQATCGDQPTEEFKTLTLHPAENGGFTGTYRSLTASNNGCNADRSVTLTRTGDVDPAIAVLEPDRMPARVPNRAEGMSGRYRVLVTDTATGETEPPMERKVRTYCVPTGERCVTLLTAENR
>NZ_AP022603.1|WP_085095857.1|3824471_3824687_+|hypothetical-protein
MFADGAWSYQISEPGRCPDGRPTVVHDRAEFALPVPASDPIEKLTGKRQLTTDAPCAGTTDGTVLVERIGD
>NZ_AP022603.1|WP_085095859.1|3824746_3825733_+|GNAT-family-N-acetyltransferase
MVETVAERAAALAGLAVFADCTVADLDPLARLLVPRNARAGEVLVRQGDPADTFLIIAAGTVEVHRDLPDGTEIAVDVDPGRIVGELALLRNSPRSATVHAITDLTGWRGGEDAFAVLIELPGVLERLIRVARQRLAAFITPVPLRLDTGQRLLLRPVLPGDNARSMHSHITFSNDTFYRRFQTARHPSEQLMRYLFEVDYVEHFVWVVVTDDGDLVADARFVRDEPDSPRAEVAFIVADAYQGHGIGTFLMGALWIAARVAGVRTFHARVLSSNQPMRAIFDHAGAHWEREDLAVVATEIDVPQTDPFEPEVTRGIEEMARRALRAL
>NZ_AP022603.1|WP_085095861.1|3825764_3826583_+|shikimate-5-dehydrogenase
MRPPLTKDTTLCISLAARPSNIGTRFHNFLYDRLGLDFLYKAFTTTDIAAAIGGVRALGIRGASVSMPFKADVLALVDRVEPSAQVIGAVNTIVNDDGRLTASNTDYLAVAQLIAAHGLSPDRSVLIAGSGGMAAAVGAAFRDSGFRDGTVVARNTDAGPALADRLGYRWRHHLGGASASIIVNVTPIGMAGGPEERDLAFPPELIAAADTVFDVVAFPSETPLIAAARAAGTPVITGAEVIAGQAAEQFERYTGVRPDPALIAEAAAYSRA
>NZ_AP022603.1|WP_085095863.1|3826587_3827274_-|LpqN/LpqT-family-lipoprotein
MPLTRTAAGLAAAALLIGATGCSKPDTAPAAPASTSGTAAPALPSLPPVPSGAEAPPIVGPVSLTEFAKANGLTATPLRHGQAGPTVELPAMDGWTLSYDLPEAPFGALVFDHPSDPDIPGRVLVTMTKLSGPVERDAVFAAAGNELRALPNFQGPATGQSSKLDGYVADQVGGLYGDDGRLVAQKTVVIPAGDVSYVLQVRASGSNQDAAALMSATADIDKKTVITE
>NZ_AP022603.1|WP_085095868.1|3827474_3828155_+|DUF5642-family-protein
MRTVLGVAVAAGLLTGCGGPAPATDTAPAESGTAVTDRAVPATGRLDPTRIKRLRAALPAGYEIADVPGDTGPAAFAGFGPGWTADPAVCATLLGPSAPVGTRGLSASGADGTVYLTVTLGDVAPPPVGDCGSWTMTYRHTTALAHPVPAPPIEGARTAGLAAESVTAVESGTRTLSRLRILTAALDGQLVAVTTITDPQQPPGPLTDEYTARLLVDAVSELRRVH
>NZ_AP022603.1|WP_085095870.1|3828161_3828836_+|DUF5642-family-protein
MLATPAPRIRAVLVAPLCAALLAGCTIDTDPSADITRIDQVRGAFGPEFTVKSVPETGIDPNRLRQEQKLPDGVVFDPADCAKLAGGQPVPDDLQGNMAAVSAEGQGNRFIVIAMETNEPMPMVEPGPECQKVSFAGPQARGTVSVIEAPQLDGVQTRAVHRVLQTTAGGKPQTGQIYSYLAHFGNYQVVVTANPLVLPGKPPMPVDTKRAAELLTAGVAAIRD
>NZ_AP022603.1|WP_109750501.1|3828832_3829429_-|alpha-ketoglutarate-dependent-dioxygenase-AlkB
MGIAVQEALFGSADRRTLGDGAWIDVRMGWFDAPAALFDELLAAVPWRAERRQMYDRVLDVPRLHSFHDLAADHLPHPVLKQLRRRLNDIYAGELGEPFASAGLCLYRDGEDSVAWHGDTIGRGATDDTMVAIVGLGATRTFALRPRGGGPSLRIQHRHGDLLVMGGSCQRTWEHAIPKTTRRVGPRISIQFRPRGVH
>NZ_AP022603.1|WP_085095872.1|3829404_3830721_+|arginine-deiminase
MLPGPRCPPPNRIAHPFDIEASAADRRAGGDTVGGVSVELGADSEVAALRAVILHRPGPELLRLTPRNNDRLLFDGLPWVARAQQEHDAFAELLRGRGVEVLLLADLLAEAMASGAARMHGISAAVDARRLGMPLAQELSAYLRTLGAAELADVLIAGMTFTELPIDHAESLVVRMHHGGDFVIDPLPNLVFTRDSSFWIGPRVAITSLAMPARQRETSLTDLIYAHHPRFLGVRRAYESRSAPVEGGDVLLLAPGVVAVGVGERTTPAGAEALARSLFDDDLAHTVLAVPIAQERAQMHLDTVCTMVDVDAVVMYPQITLPAYTVHRTGSGVRIDPERPFLAAAADAMGIAALRVIDTGLDAVTAEREQWDDGNNTLALAPGVVVAYERNTQTNARLADAGIEVLPIAASELGTGRGGPRCMSCPIARDPLPLPPGR

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Crispr_ID: NZ_AP022603_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022603_17

3863549-3863638

Unclear

Consensus_repeat	Method
GCGTATGCGGCCGGCCGTTCGCTCT	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_AP022603_17

>merge|NZ_AP022603|17|3863549-3863638|CRISPRCasFinder
GCGTATGCGGCCGGCCGTTCGCTCTAGCTCCGCTGGCGCTCCGCAAGAGCTCCGCAGTCCGCGAAGCGTACGCGGCCGGCCGTTCGCTCT

>NZ_AP022603|17|15|3863549-3863638|CRISPRCasFinder
GCGTATGCGGCCGGCCGTTCGCTCT	AGCTCCGCTGGCGCTCCGCAAGAGCTCCGCAGTCCGCGAA
GCGTACGCGGCCGGCCGTTCGCTCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022603.1\|WP_085092661.1\|3863730_3865011_+\|phosphopyruvate-hydratase	unknown	unknown	gnl\|CDD\|234617
NZ_AP022603.1\|WP_085092666.1\|3867690_3867915_-\|antitoxin-MazE-family-protein	unknown	unknown	gnl\|CDD\|371540
NZ_AP022603.1\|WP_085092664.1\|3866306_3867260_+\|Ppx/GppA-family-phosphatase	unknown	unknown	gnl\|CDD\|223326
NZ_AP022603.1\|WP_085092653.1\|3851808_3853245_-\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	unknown	unknown	gnl\|CDD\|184641
NZ_AP022603.1\|WP_085092669.1\|3870188_3871040_-\|patatin-like-phospholipase-family-protein	unknown	unknown	gnl\|CDD\|224666
NZ_AP022603.1\|WP_085092689.1\|3860575_3861694_-\|cupredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|271139
NZ_AP022603.1\|WP_085092654.1\|3853399_3854035_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_AP022603.1\|WP_085092658.1\|3859281_3860592_-\|deferrochelatase/peroxidase-EfeB	unknown	unknown	gnl\|CDD\|273606
NZ_AP022603.1\|WP_085092651.1\|3850225_3850564_-\|arsenate-reductase-(glutaredoxin)	unknown	unknown	gnl\|CDD\|239332
NZ_AP022603.1\|WP_085092652.1\|3850566_3851547_-\|ribose-phosphate-diphosphokinase	unknown	unknown	gnl\|CDD\|179535
NZ_AP022603.1\|WP_085092659.1\|3861744_3862674_-\|FTR1-family-protein	unknown	unknown	gnl\|CDD\|272930
NZ_AP022603.1\|WP_085092663.1\|3865800_3866310_+\|DUF501-domain-containing-protein	unknown	unknown	gnl\|CDD\|224424
NZ_AP022603.1\|WP_085092656.1\|3854675_3858344_+\|transcription-repair-coupling-factor	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|224118
NZ_AP022603.1\|WP_085092668.1\|3869170_3870187_+\|patatin-like-phospholipase-family-protein	unknown	unknown	gnl\|CDD\|132866
NZ_AP022603.1\|WP_085092665.1\|3867364_3867694_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|367091
NZ_AP022603.1\|WP_085092657.1\|3858340_3859312_+\|nucleoside-triphosphate-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|237065
NZ_AP022603.1\|WP_085092667.1\|3867969_3868425_-\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_AP022603.1\|WP_085092655.1\|3854040_3854577_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_109750375.1\|3868508_3869144_+\|LysE-family-transporter	unknown	unknown	gnl\|CDD\|224199
NZ_AP022603.1\|WP_085092662.1\|3865031_3865808_+\|septum-formation-initiator-family-protein	unknown	unknown	gnl\|CDD\|225471

Protein	Function_ID	Function_description	E-value
NZ_AP022603.1\|WP_085092661.1\|3863730_3865011_+\|phosphopyruvate-hydratase	gnl\|CDD\|234617	PRK00077, eno, enolase; Provisional.	0
NZ_AP022603.1\|WP_085092666.1\|3867690_3867915_-\|antitoxin-MazE-family-protein	gnl\|CDD\|371540	pfam11455, DUF3018, Protein of unknown function (DUF3018). This is a bacterial family of uncharacterized proteins.	4.70094e-20
NZ_AP022603.1\|WP_085092664.1\|3866306_3867260_+\|Ppx/GppA-family-phosphatase	gnl\|CDD\|223326	COG0248, GppA, Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism].	1.46518e-93
NZ_AP022603.1\|WP_085092653.1\|3851808_3853245_-\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	gnl\|CDD\|184641	PRK14352, glmU, bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU.	0
NZ_AP022603.1\|WP_085092669.1\|3870188_3871040_-\|patatin-like-phospholipase-family-protein	gnl\|CDD\|224666	COG1752, RssA, Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only].	3.41293e-22
NZ_AP022603.1\|WP_085092689.1\|3860575_3861694_-\|cupredoxin-domain-containing-protein	gnl\|CDD\|271139	cd14656, Imelysin-like_EfeO, EfeO is a component of the EfeUOB operon. This family includes the EfeO domain, an essential component of the EfeUOB operon which is highly conserved in bacteria. However, its biochemical function is unknown. EfeO contains an N-terminal cupredoxin (CUP)-like domain and C-terminal imelysin-like domain that may bind iron. Algp7, a member of EfeO family protein from Sphingomonas sp. A1, is found to bind alginate at neutral pH, but does not contain the CUP domain, thus having a role that does not seem to be related to iron uptake. Some members of this family are fused to an N-terminal putative EfeU ion permease domain. The imelysin-like domain of this family also contains the GxHxxE sequence motif and a highly conserved functional site, suggesting a similar role to other imelysin family proteins containing the same motif.	9.69725e-91
NZ_AP022603.1\|WP_085092654.1\|3853399_3854035_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.41477e-19
NZ_AP022603.1\|WP_085092658.1\|3859281_3860592_-\|deferrochelatase/peroxidase-EfeB	gnl\|CDD\|273606	TIGR01412, Probable_deferrochelatase/peroxidase_EfeN, Tat-translocated enzyme. This model represents a small family of proteins with a typical Tat (twin-arginine translocation) signal sequence, suggesting that the family is exported in a folded state, perhaps with a bound redox cofactor. Members of this family show homology to Dyp, a dye-decolorizing peroxidase from Geotrichum candidum that lacks any typical heme-binding site.	1.19043e-158
NZ_AP022603.1\|WP_085092651.1\|3850225_3850564_-\|arsenate-reductase-(glutaredoxin)	gnl\|CDD\|239332	cd03034, ArsC_ArsC, Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the detoxification of arsenic, using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX). ArsC contains a single catalytic cysteine, within a thioredoxin fold, that forms a covalent thiolate-As(V) intermediate, which is reduced by GRX through a mixed GSH-arsenate intermediate. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases.	1.85688e-51
NZ_AP022603.1\|WP_085092652.1\|3850566_3851547_-\|ribose-phosphate-diphosphokinase	gnl\|CDD\|179535	PRK03092, PRK03092, ribose-phosphate diphosphokinase.	0
NZ_AP022603.1\|WP_085092659.1\|3861744_3862674_-\|FTR1-family-protein	gnl\|CDD\|272930	TIGR00145, Uncharacterized_protein_slr0964, FTR1 family protein. A characterized member from yeast acts as oxidase-coupled high affinity iron transporter. Note that the apparent member from E. coli K12-MG1655 has a frameshift by homology with member sequences from other species. [Unknown function, General].	1.3637e-36
NZ_AP022603.1\|WP_085092663.1\|3865800_3866310_+\|DUF501-domain-containing-protein	gnl\|CDD\|224424	COG1507, COG1507, Uncharacterized conserved protein [Function unknown].	1.51186e-83
NZ_AP022603.1\|WP_085092656.1\|3854675_3858344_+\|transcription-repair-coupling-factor	gnl\|CDD\|224118	COG1197, Mfd, Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription].	0
NZ_AP022603.1\|WP_085092668.1\|3869170_3870187_+\|patatin-like-phospholipase-family-protein	gnl\|CDD\|132866	cd07228, Pat_NTE_like_bacteria, Bacterial patatin-like phospholipase domain containing protein 6. Bacterial patatin-like phospholipase domain containing protein 6. PNPLA6 is commonly known as Neuropathy Target Esterase (NTE). NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. This group includes YCHK and rssA from Escherichia coli as well as Ylbk from Bacillus amyloliquefaciens.	8.6614e-77
NZ_AP022603.1\|WP_085092665.1\|3867364_3867694_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	2.07254e-25
NZ_AP022603.1\|WP_085092657.1\|3858340_3859312_+\|nucleoside-triphosphate-pyrophosphohydrolase	gnl\|CDD\|237065	PRK12334, PRK12334, nucleoside triphosphate pyrophosphohydrolase; Reviewed.	2.74017e-105
NZ_AP022603.1\|WP_085092667.1\|3867969_3868425_-\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	1.10543e-38
NZ_AP022603.1\|WP_109750375.1\|3868508_3869144_+\|LysE-family-transporter	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	5.42429e-19
NZ_AP022603.1\|WP_085092662.1\|3865031_3865808_+\|septum-formation-initiator-family-protein	gnl\|CDD\|225471	COG2919, COG2919, Septum formation initiator [Cell division and chromosome partitioning].	4.77492e-17

>NZ_AP022603.1|WP_085092659.1|3861744_3862674_-|FTR1-family-protein
MTTGAAASTLTLLAAPSTSSQLFGSFLIGLREGLEAAIVVSILVAFLVKSGRRDALKWVWLGVGSAVLMTVVVFLGIQLGENTIQDLAAEAFAGVASLLAVVIVTSMVLWMKKASAGLSGELRDGMTRALDTGGVAVLALSFLAVGREGLETALFMVGYANASTAWPLTGLILGVLVAAAIAYAMYRGAVRFDLGKFFRYTGIFLIVVAAGILSYGIGALQTVGWLPVLTGKAFDVSALFTWSSDHLFGRFMQGVTGAVEGIFNISPNPTVLQLLCWAGYLIVVLMVFLRPARTTVETPTQRSAERSTT
>NZ_AP022603.1|WP_085092689.1|3860575_3861694_-|cupredoxin-domain-containing-protein
MAVAALGASVLAGCTAKDAGKDGAAGEPITVSATDTECALSATSGSTGANTFLITNNGTKVTEFYVYDRGDRVMGEVENVSPGLQRKLIVQLPESGTYQTACKPGMVGDGIRGDFTVTGEAVQLDTEGKFKEAADSYKRYIVSQTEALVTATTEFVTAIKAGDVAKAKAQYPLARTYYERIEPVAESFPNDLDPRVDQREADLSEGETWGGFHRLEKDLWVTGLQPSSNAVADQLLADIKELHAGVSAPDFRVDSTKIAGGAQSLLDEISNSKLSGEEDIFSHTDLFDFNANIEGSQTAVASVRPILDERNPDLGKRVDQRFADVEALLQKYREGDGFISYDKVTEAQRQELSRAIDALSKEVSQVQGVIAG
>NZ_AP022603.1|WP_085092658.1|3859281_3860592_-|deferrochelatase/peroxidase-EfeB
MSSPDSGPASEPDGGGLFSRRRLLGAAGVSAAVVGAAGAGALAGRASAADPQAAMNAAVPFRGVRQAGIVTPAQDRMHFATFDLTTDRRDDVIKMLREWTHMAERMTAGAQAARDGAVGLNPYSPPTDTGEALGLPASALTLTIGFGPSFFGRDGKDPLGIAGRRPELLADLPKFPNETMDPSQCGGDICIQACANDPQVAVHAVRNLARVGFGTAAVRWSQLGFGRTSSTSHAQQTPRNLFGFKDGTANIMAEDTGTLDEQVWVRDGDGPDWLTGGSYLITRRIRMRIEPWDRTTLIEQERVIGRAKGSGAPLGRADEFDALPLDLTGDDGEPVIDPLAHVRLASPEDNDGVQILRRGYNFTDGTDGFGHLDAGLFFIAFVRNPATQFIPMQTKLAKRDLLTEYIVHTGTGIFATPPGIPDGDPDAYWGSTLLEG
>NZ_AP022603.1|WP_085092657.1|3858340_3859312_+|nucleoside-triphosphate-pyrophosphohydrolase
MTVVLVDPRQPELIPVDAVELLTGAVQYTEELPPKVIWTLPSARPVGTGEPAPVLLSSNRDHPQVRARLTAGERLLAAPDPRRGERLLEAVEVMDRLRTNGPWESQQTHDSLRRYLLEETYELFDAVRSGDADELRGELGDVLLQVLFHARIAEDAPVRPFDIDDVADALIRKLANRVPAVLAGEQISLEDQLAQWEERKALEKSARSPGPGEDMVSVMDDLPTATPALLLAQKALARAQQAGLPEDLIPADLRTVSVSADFDAENHLRTVVLAFIDEVRGAERRIGAARGEIDGSAIGSAGEQEWRAAWPAAGQPSSSVEPQ
>NZ_AP022603.1|WP_085092656.1|3854675_3858344_+|transcription-repair-coupling-factor
MTKPGHTHVQTPIAGLVELALTAPTLTELAERAAAAPQTLDIVAPPAAQPFVAAALARQHPLLVVTATGREADDLTAELRGVYGDAVALFPSWETLPHERLSPGVDTVGARLLLLRRLARPDDERLGPPLKVVVTTARSLLQPMARGDGAATDAEPVTLAVGAEAGFDDVVTRLVELAYTRVDMVGKRGEFAVRGGILDIFAPTAEHPVRVEFWGDEVSEMRMFSVADQRSIPEVPIGHLVAVPCRELLLTDAVRDRAAQLAGATPTTDNTVVGTVGEMLAKLAEGIPVDGMEALAPVLWADGLTLLSDHLPEGAPLLICDPEKVRTRSADLIKTGREFLDASWSVAAMGADAPIDIEALGGSGFRGLAEVREAAEAGGHPWWTLSQLPNEAALELDIRPAPTTRGSQAGIDEVFAMLRAHAATGGVAAIVAPGTGTANRVVEQLGGADVPAALLEPGATPPPGVVGVLRGPLHTGIVLPGANLVVITETDLTGNRVTAGEGKRLAAKRRNTVDPLALAAGDLVVHDQHGIGKFVEMTERIVGGARREYLVLEYASAKRGGGTDKLYVPMDSLDQLSRYVGGTAPTLSRLGGSDWTNTKTKARKAVREIATELVALYAKRQAAPGHAFGPDSPWQAEMEDAFGFTETVDQLTAITEVKADMEKPIPMDRVICGDVGYGKTEIAVRAAFKAIQDGKQVAVLVPTTLLADQHLQTFTTRMAGFPVTVKGLSRFTDPADSKAVVAGLADGSVDVVIGTHRLLQTGVRWKDLGLVIVDEEQRFGVEHKEHIKGLRSHVDVLTMSATPIPRTLEMSLAGIREMSTILTPPEERYPVLTYVGPHDDKQVAAALRRELLRDGQAFYIHNRVRSIDDAAARVRALVPEARVVVAHGQMPEEQLERTVQGFWHREFDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLRGRVGRSRERGYAYFLYPPEVPLTETAHDRLATIAQNNDLGAGMAVALKDLEIRGAGNVLGVEQSGHVAGVGFDLYVRLVGEAVEAYRAAADGQTVTTSEPKEVRIDLPIDAHLPPDYIGSDRLRLEGYRRLASAADDDAVRAVVEELTDRYGPLPEPARRLVAVARLRLLCRRYGVTEVSATGSAGQPATLRLAPLTLLDSQQLRLSRMYPGAAYRATTSVVQVPIPRAGSGIGAPRIRDVELAQAVADLLLALDGRPQGEVDLTDLSTPVGEGDSA
>NZ_AP022603.1|WP_085092655.1|3854040_3854577_-|hypothetical-protein
MHRTVFCTIAAVTVVAAAPAVALADPGIPDFASYPKVTAADYTVRDGLAYSVRGFRTPSGLNCTSSQHRDMYALDCTGGLVGLPDGANWIRLRASGPVVSAPTFSTAEDRPSVEGVPQFEATPLPLLPAGQLYAFDAAQCVWTDTVALACKFASREKPDAEYTGFVATTTGTTTFGNL
>NZ_AP022603.1|WP_085092654.1|3853399_3854035_+|TetR/AcrR-family-transcriptional-regulator
MAAPDNQARAPRSRMTGTERRHQLIDVGRALFAERGYDGTSIEEIAQRAGVSKPVVYEHFGGKEGLYAVVVDREMSVLLDGITSSLTNNRSRVRVERVALALLTYVEEHTDGFRILIRDSPASISSGTYSSLLNDAVGQVSSILAGDFARRGLDPDLAQLYAQALVGSVSMTAQWWLDVREPPKEAVAAHLVNLCWNGLTHLESDPVLHEE
>NZ_AP022603.1|WP_085092653.1|3851808_3853245_-|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU
MTTRDAVVVLAAGAGTRMRSDTPKVLHTLGGRSMLSHAVHTAAGTEPEHLVVILGHDRERIAPVVEELAAQLGREIRIAVQDEQLGTGHAVACGLTALPDDFDGTVVVTSGDVPLLDAATLSALTDHHRGGAAATVLTTTVADSTGYGRILRTQDGEVIAIVEEADATPQQRAIAEINSGVYAFAIDALRSALDRLSSNNAQHELYLTDVIAIARAEGRSVRGLHVDDAALVAGVNDRVQLSALSAELNRRLVANLQRSGVTVIDPATTWIDVEVSVGRDTVIHPGTQLQGSTVVGTHCTVGPDSTLRDVAVGDGASVVRTHGRQSQIGPGAEVGPFAYLRPGTVLGADGKIGTFVEVKNSAIGAGTKVPHLTYVGDADIGEHSNIGASSVFVNYNGETKSRTTIGSHVRTGSDTMFVAPVAVGDGAYTGAGTVLRHDVPPGALAFSDNTQHTVEGWVEEKRPGSESASAAKRARGQD
>NZ_AP022603.1|WP_085092652.1|3850566_3851547_-|ribose-phosphate-diphosphokinase
MGQDWTDNRKNLMLFAGRAHPELAEQVAKELGVEVTPQTARDFANGEIFVRFQESVRGCDAFVLQSHPAPLNTWLMEQLIMIDALKRGSAKRITAIMPFYPYARQDKKHRGREPISARLVADLLKTAGADRIITVDLHTDQIQGFFDGPVDHMRGQSLLCGYIGNRYSDQDLVVVSPDSGRVRVAEKWADALGGVPLAFIHKTRDPLVPNQVVSNRVVGEVQGKTCILTDDMIDTGGTIAGAVKLLYADGAKDVIIAATHGVLSDPAAQRLADCGAREVIVTNTLPITEDKQFPSLTVLSIAPLLASTIREVFDNGSVTGLFDGSA
>NZ_AP022603.1|WP_085092651.1|3850225_3850564_-|arsenate-reductase-(glutaredoxin)
MARIYHNPKCSTSRKTLDLLRENGIEPEIVLYLKNPPTRAELVTLISDAGIEVSKAVRKRESAYAELNLAEADDDQLLDAMAANPILIERPFVVTDKGTRLARPIESVNEIL
>NZ_AP022603.1|WP_085092661.1|3863730_3865011_+|phosphopyruvate-hydratase
MPIIEQVGAREILDSRGNPTVEVELALIDGTVARADVPSGASTGEHEAVELRDGGSRYGGKGVEKAVEAVLDEIAPAVIGLSADDQRVIDQTLLDLDGTPDKSRLGANAILGVSLAVAKAAADSAGLPLFRYVGGPNAHILPVPMMNILNGGAHADTGVDVQEFMIAPIGAPSFREALRWGAEVYHSLKAVLKKQGLSTGLGDEGGFAPDVAGTQAALDLILSAIDATGLKPGSDVALALDVAATEFYTDGTGYAFERETRTAEQMTAFYASLIDAYPLVSIEDPLSEDDWDGWISLTTAIGDKVQIVGDDLFVTNPERLEDGIERGAANALLVKVNQIGTLTETLDAVALAHHAGYKTMMSHRSGETEDTIIADLAVAVGSGQIKTGAPARSERVAKYNQLLRIEEMLGDAARYAGDLAFPRFSV
>NZ_AP022603.1|WP_085092662.1|3865031_3865808_+|septum-formation-initiator-family-protein
MSDGKRPDPRRRAPGSRPAAAGRTGPAARGRKSASSSPSAPGAKGTPKSGPKPVADPDAETTDGEAEAPTRAMPEIIEPIRQAIVDSANRQAEQRLGFTARRAAILAAVVCVLTLTIAGPVRTFFAQRTEMRQLAATEEALRAQIADLEIQKVKLADPAFIASEARERLGFVMPGDIPYQVQLPEGAVPPGEPGAPGKATAPSSDPWYTALWKTIADEPHGPHQPPAGTVGPEQLPPGEVPPGELPPIDAPPPAGPGG
>NZ_AP022603.1|WP_085092663.1|3865800_3866310_+|DUF501-domain-containing-protein
MVDPGDLAAVATQLGREPRGVLAIAYRCPNGEPAVVKTAPKLPDGTPFPTLYYLTHPALTAAASRLETTGMMREMTARLGNDAELAAAYRRAHESFLAERDAIEPLGTTFSGGGMPDRVKCLHVVIAHSLAKGPGVNPFGDEALAVLASESGMAGILDRDVWLPAGEPR
>NZ_AP022603.1|WP_085092664.1|3866306_3867260_+|Ppx/GppA-family-phosphatase
MSRVGAIDCGTNSIRLLIADLALEGGRWRSTDVVREMRIVRLGEGVDATGRFAAAALDRTRAALIEYAELLAAHEVSRIRMVATSATRDAANREEFFAMTAEVLGAVVPGAVAEVITGEQEAALSFRGAVAELDSADGPFVVVDLGGGSTELVRGGADVDAATSVNIGCVRLTERCLQSDPPTAGEVSAARAVAAERIAAALAAVPVDGARSWVGVAGTFTTLAALAMRLPEYDAEVIHLSRVGFPELLAVCEELIGMTRAQRAALGPMHAGRVDVIGGGAIVVQELARELGARMGIDTLVVSEHDILDGIAQSIAG
>NZ_AP022603.1|WP_085092665.1|3867364_3867694_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MIRGEIWTASARQGYAGKPRPVVIVQDDRFDATDSITFCPFTSVAAAIPLLRIPVSPNAANGLSAPSSVMVDKITTAHKSKLDRRIGAVSPSEMREIERALLVFLGLTG
>NZ_AP022603.1|WP_085092666.1|3867690_3867915_-|antitoxin-MazE-family-protein
MASPDTNKRVADHRARLRGQGLRPLQIWVPDTRSAEFAAEAHRQSALAAIADRESGDQDWVDDVSEFNDPDFDR
>NZ_AP022603.1|WP_085092667.1|3867969_3868425_-|Lrp/AsnC-family-transcriptional-regulator
MDAIDRKILAELQVQGRISTTDLAARVGLTVAPTHRRIRDLEAAGAIVGYRAVIDPKALGLNFEALVFVTMKQEDRATLLGFEEAAAAVPNILQAYRLFGDPDFLLRVRTADLESYTRLQDDVLALLPGVQRFTSTLVMKDVVGDRPYPTG
>NZ_AP022603.1|WP_109750375.1|3868508_3869144_+|LysE-family-transporter
MELSVLAAFAVVAFTLVVVPGPDWAYVLAAGARDHVVVPAVGGILIGYAAVTAVVVAGVGTLVAAAPAALAVLTLAGAGYVGYLGVRVLRAPAGFEAAAEGSSPTASVFSYLARGAGVSASNPKGLLIFLAILPQFTRASSSWPIAAQMTALAGVFLLACALVYLTVGHAANRVLGSRPGLATVTTRISGVAMILIGLGLIAEQGVHLLAA
>NZ_AP022603.1|WP_085092668.1|3869170_3870187_+|patatin-like-phospholipase-family-protein
MQVALALGSGGARGYAHIGVVDELQARGHEVVGVAGSSMGALVGGVLAAGKLDEFSDWARSLTQRAVLMLMDPALNAAGVLRAEKVLDAVRGILGPVQIEDLDIPYTAVATDLITGRSVWLQRGPVDDAIRASIAIPGVISPHILDGRLLGDGGILDPIPMAPIAAVRADVTIAVTFAGNGPEDPADQQPNRTTDWWNRVWRNTSASLLDTKAARSLRETTTGRALLSRLTPDEDLGEPGSAETEPAEAEPAETEPDDAAAAPRLGGFEVMNRSFDIAQAALARHTLAAYPPDLLIEVPRTVCRSLEFYRAEEVIAVGRAYAADALDAFEAQNAAADG
>NZ_AP022603.1|WP_085092669.1|3870188_3871040_-|patatin-like-phospholipase-family-protein
MTRALVLAGGGIAGIAWETGVLAGIADVAPAAATALLTADVLVGTSAGATVAAQLGSGLSPAELFARQLAATSAEIDSGVDVDTIAGMFLSALTIPDATKAQRLARIGEVAAATPTVSEPVRRAVIAARLPSHDWPARTTRLTAVDVASGELVVFDATSGVDLVDAVAASCAVPGAWPPVTIGDRRYMDGGVASSVNMAVAADCDRAVVLVPSGADAPSPWPVGTAAEIAAFDGACAAVFADAEALAAFGTNPLNPACRIPSARAGRAQGRREAARIAEFLGG

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Crispr_ID: NZ_AP022603_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022603_18

3904816-3904965

Orphan

Consensus_repeat	Method
GCCCCTAGAGTTTGCGCAGCCGCAGCCGGTTGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022603_18

>merge|NZ_AP022603|18|3904816-3904965|CRISPRCasFinder
TGCCCTACAGTTTGCGCAGCCGCAGCCGGTTGATCTGCCGGCGGGACAGGTGCCCCTAGAGTTTGCGCAGCCGCAGCCGGTTGATCGAGTGGGCCGTACTGCCGGCTGGCCAGGGAGCCCCTAGAGTTTGCGGAGCCGCAGCCGGTTGAT

>NZ_AP022603|18|16|3904816-3904965|CRISPRCasFinder
TGCCCTACAGTTTGCGCAGCCGCAGCCGGTTGAT	CTGCCGGCGGGACAGGTGCCCCTAGAGTTTGCGCAGCCGCAGCCGGTTGATCGAGTGGGCCGTACTGCCGGCTGGCCAGGGA
GCCCCTAGAGTTTGCGGAGCCGCAGCCGGTTGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022603.1\|WP_085095440.1\|3917504_3918299_+\|dienelactone-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223489
NZ_AP022603.1\|WP_085095445.1\|3914150_3915551_-\|class-II-fumarate-hydratase	unknown	unknown	gnl\|CDD\|234779
NZ_AP022603.1\|WP_085095463.1\|3902812_3904201_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379724
NZ_AP022603.1\|WP_085095469.1\|3896947_3898945_+\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|224250
NZ_AP022603.1\|WP_109750482.1\|3911801_3912653_+\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|213022
NZ_AP022603.1\|WP_085095447.1\|3912722_3913952_-\|YncE-family-protein	unknown	unknown	gnl\|CDD\|225926
NZ_AP022603.1\|WP_085095461.1\|3904259_3904670_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085095455.1\|3907540_3908995_+\|glycine-hydroxymethyltransferase	unknown	unknown	gnl\|CDD\|184161
NZ_AP022603.1\|WP_085095453.1\|3909135_3909960_+\|acyl-ACP-desaturase	unknown	unknown	gnl\|CDD\|153109
NZ_AP022603.1\|WP_085095442.1\|3916713_3917454_+\|DUF4245-domain-containing-protein	unknown	unknown	gnl\|CDD\|379430
NZ_AP022603.1\|WP_085095443.1\|3915615_3916671_-\|class-II-fructose-bisphosphatase	unknown	unknown	gnl\|CDD\|236536
NZ_AP022603.1\|WP_085095467.1\|3900510_3901308_+\|isoprenyl-transferase	unknown	unknown	gnl\|CDD\|237825
NZ_AP022603.1\|WP_085095473.1\|3895719_3896583_+\|mycothiol-conjugate-amidase-Mca	unknown	unknown	gnl\|CDD\|132487
NZ_AP022603.1\|WP_085095457.1\|3905941_3907150_+\|DUF885-domain-containing-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085095483.1\|3898955_3899321_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|238404
NZ_AP022603.1\|WP_085095465.1\|3901313_3902774_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|341286
NZ_AP022603.1\|WP_085095451.1\|3910148_3911477_+\|PhoH-family-protein	unknown	unknown	gnl\|CDD\|224787
NZ_AP022603.1\|WP_085095481.1\|3899663_3900521_-\|hemolysin-III-family-protein	unknown	unknown	gnl\|CDD\|273425
NZ_AP022603.1\|WP_085095475.1\|3895141_3895579_-\|DUF4307-domain-containing-protein	unknown	unknown	gnl\|CDD\|379491
NZ_AP022603.1\|WP_085095471.1\|3896579_3896876_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP022603.1\|WP_085095440.1\|3917504_3918299_+\|dienelactone-hydrolase-family-protein	gnl\|CDD\|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	7.86086e-13
NZ_AP022603.1\|WP_085095445.1\|3914150_3915551_-\|class-II-fumarate-hydratase	gnl\|CDD\|234779	PRK00485, fumC, fumarate hydratase; Reviewed.	0
NZ_AP022603.1\|WP_085095463.1\|3902812_3904201_+\|hypothetical-protein	gnl\|CDD\|379724	pfam15420, Abhydrolase_9_N, Alpha/beta-hydrolase family N-terminus. This is the N-terminal transmembrane domain of a family of alpha/beta hydrolases which may function as lipases. The C-terminal domain (pfam10081) is the catalytic domain.	0.000104831
NZ_AP022603.1\|WP_085095469.1\|3896947_3898945_+\|thioredoxin-domain-containing-protein	gnl\|CDD\|224250	COG1331, COG1331, Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones].	0
NZ_AP022603.1\|WP_109750482.1\|3911801_3912653_+\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|213022	cd10917, CE4_NodB_like_6s_7s, Catalytic NodB homology domain of rhizobial NodB-like proteins. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes many rhizobial NodB chitooligosaccharide N-deacetylase (EC 3.5.1.-)-like proteins, mainly from bacteria and eukaryotes, such as chitin deacetylases (EC 3.5.1.41), bacterial peptidoglycan N-acetylglucosamine deacetylases (EC 3.5.1.-), and acetylxylan esterases (EC 3.1.1.72), which catalyze the N- or O-deacetylation of substrates such as acetylated chitin, peptidoglycan, and acetylated xylan. All members of this family contain a catalytic NodB homology domain with the same overall topology and a deformed (beta/alpha)8 barrel fold with 6- or 7 strands. Their catalytic activity is dependent on the presence of a divalent cation, preferably cobalt or zinc, and they employ a conserved His-His-Asp zinc-binding triad closely associated with the conserved catalytic base (aspartic acid) and acid (histidine) to carry out acid/base catalysis. Several family members show diversity both in metal ion specificities and in the residues that coordinate the metal.	1.03443e-67
NZ_AP022603.1\|WP_085095447.1\|3912722_3913952_-\|YncE-family-protein	gnl\|CDD\|225926	COG3391, COG3391, Uncharacterized conserved protein [Function unknown].	2.28412e-09
NZ_AP022603.1\|WP_085095451.1\|3910148_3911477_+\|PhoH-family-protein	gnl\|CDD\|224787	COG1875, COG1875, NYN ribonuclease and ATPase of PhoH family domains [General function prediction only].	0
NZ_AP022603.1\|WP_085095455.1\|3907540_3908995_+\|glycine-hydroxymethyltransferase	gnl\|CDD\|184161	PRK13580, PRK13580, glycine hydroxymethyltransferase.	0
NZ_AP022603.1\|WP_085095453.1\|3909135_3909960_+\|acyl-ACP-desaturase	gnl\|CDD\|153109	cd01050, Acyl_ACP_Desat, Acyl ACP desaturase, ferritin-like diiron-binding domain. Acyl-Acyl Carrier Protein Desaturase (Acyl_ACP_Desat) is a mu-oxo-bridged diiron-carboxylate enzyme, which belongs to a broad superfamily of ferritin-like proteins and catalyzes the NADPH and O2-dependent formation of a cis-double bond in acyl-ACPs. Acyl-ACP desaturases are found in higher plants and a few bacterial species (Mycobacterium tuberculosis, M. leprae, M. avium and Streptomyces avermitilis, S. coelicolor). In plants, Acyl-ACP desaturase is a plastid-localized, covalently ACP linked, soluble desaturase that introduces the first double bound into saturated fatty acids, resulting in the corresponding monounsaturated fatty acid. Members of this class of soluble desaturases are specific for a particular substrate chain length and introduce the double bond between specific carbon atoms. For example, delta 9 stearoyl-ACP is specific for stearic acid and introduces a double bond between carbon 9 and 10 to yield oleic acid in the ACP-bound form. The enzymatic reaction requires molecular oxygen, NAD(P)H, NAD(P)H ferredoxin oxido-reductase and ferredoxin. The enzyme is active in the homodimeric form; the monomer consists mainly of alpha-helices with the catalytic diiron center buried within a four-helix bundle. Integral membrane fatty acid desaturases that introduce double bonds into fatty acid chains, acyl-CoA desaturases of animals, yeasts, and fungi, and acyl-lipid desaturases of cyanobacteria and higher plants, are distinct from soluble acyl-ACP desaturases, lack diiron centers, and are not included in this CD.	1.02463e-39
NZ_AP022603.1\|WP_085095442.1\|3916713_3917454_+\|DUF4245-domain-containing-protein	gnl\|CDD\|379430	pfam14030, DUF4245, Protein of unknown function (DUF4245). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 188 and 235 amino acids in length.	1.79175e-55
NZ_AP022603.1\|WP_085095443.1\|3915615_3916671_-\|class-II-fructose-bisphosphatase	gnl\|CDD\|236536	PRK09479, glpX, fructose 1,6-bisphosphatase II; Reviewed.	0
NZ_AP022603.1\|WP_085095467.1\|3900510_3901308_+\|isoprenyl-transferase	gnl\|CDD\|237825	PRK14828, PRK14828, undecaprenyl pyrophosphate synthase; Provisional.	2.98199e-125
NZ_AP022603.1\|WP_085095473.1\|3895719_3896583_+\|mycothiol-conjugate-amidase-Mca	gnl\|CDD\|132487	TIGR03446, mycothiol_Mca, mycothiol conjugate amidase Mca. Mycobacterium tuberculosis, Corynebacterium glutamicum, and related species use the thiol mycothiol in place of glutathione. This enzyme, homologous to the (dispensible) MshB enzyme of mycothiol biosynthesis, is described as an amidase that acts on conjugates to mycothiol. It is a detoxification enzyme. [Cellular processes, Detoxification].	0
NZ_AP022603.1\|WP_085095481.1\|3899663_3900521_-\|hemolysin-III-family-protein	gnl\|CDD\|273425	TIGR01065, Hypothetical_UPF0073_protein_yqfA., channel protein, hemolysin III family. This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role.	5.61317e-70
NZ_AP022603.1\|WP_085095465.1\|3901313_3902774_+\|AMP-binding-protein	gnl\|CDD\|341286	cd17631, FACL_FadD13-like, fatty acyl-CoA synthetase, including FadD13. This family contains fatty acyl-CoA synthetases, including Mycobacterium tuberculosis acid-induced operon MymA encoding the fatty acyl-CoA synthetase FadD13 which is essential for virulence and intracellular growth of the pathogen. The fatty acyl-CoA synthetase activates lipids before entering into the metabolic pathways and is also involved in transmembrane lipid transport. However, unlike soluble fatty acyl-CoA synthetases, but like the mammalian integral-membrane very-long-chain acyl-CoA synthetases, FadD13 accepts lipid substrates up to the maximum length of C26, and this is facilitated by an extensive hydrophobic tunnel from the active site to a positively charged patch. Also included is feruloyl-CoA synthetase (Fcs) in Rhodococcus strains where it is involved in biotechnological vanillin production from eugenol and ferulic acid via a non-beta-oxidative pathway.	1.48462e-155
NZ_AP022603.1\|WP_085095483.1\|3898955_3899321_+\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|238404	cd00781, ketosteroid_isomerase, ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon. Ketosteroid isomerases are important members of this class of enzymes which are the most proficient of all enzymes known and have served as a paradigm for enzymatic enolizations since its discovery in 1954. This CD includes members of this class that calalyze the isomerization of various beta,gamma-unsaturated isomers at nearly a diffusion-controlled rate. These enzymes are widely distributed in bacteria.	3.98695e-27
NZ_AP022603.1\|WP_085095475.1\|3895141_3895579_-\|DUF4307-domain-containing-protein	gnl\|CDD\|379491	pfam14155, DUF4307, Domain of unknown function (DUF4307). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 132 and 153 amino acids in length. There is a single completely conserved residue C that may be functionally important.	1.77333e-34

>NZ_AP022603.1|WP_085095461.1|3904259_3904670_+|hypothetical-protein
MTTQLAGNPTVRSEDALVRTAMRVDAVLVGVVGIPFVAAARPLAEWTGIPQAFVLGLGIFFLVYAVDVYWLAGRDRVAPGAWATIVANEVCTLAALAVVVLGVWPLTGVGVAALLFSAVYTAVFAAAQWIGLRRLG
>NZ_AP022603.1|WP_085095463.1|3902812_3904201_+|hypothetical-protein
MAALSVLTFALSWWLGLYLLGRDRRKPVLALAAAGLCGFALVVALDAVRLSAGNPEPLGRVEIFLVIVPGVAWLAVLLELARPAQRWRRRGAERAAVVAVAVLAVVGAALAGGVDPPLRFGHWLMFAVISVSTLAALVLAVRRAPRPGSVIGVIVVATLFFALANAILVIPLGILPSWLALASTGFDVLLLGLAVALWDAFDEGQALRADMRRSFAGAMAVAVLFGAQGMVGIAATDGAARTVVTALTFTSVGVAVALTVLADPLAGLLDRLVFARAPELRADRAVLRDTEAALPLRRPNPLDEVDGETFTRLTRRALGHYGNLSKLVASPLTALPMIDERLAARGLPDQPLERANELKALLAERIAALKPRGDDDFGTSDEWRYYNALYFPYIAGVRAYAQNATAAGLDPAGRAAWQWLVTEVPQRSLHNWQNSAAKLIATDLRGRMAVSGSTERRPGSRR
>NZ_AP022603.1|WP_085095465.1|3901313_3902774_+|AMP-binding-protein
MLADLLAPAVATAPDRPAVIDDAGMITFAELDARSAALAGWLSTVTDPGDRVAVVADNSVHYALAYYAVPRAGRVLALINQRLDPVEQAEQIAVAGARLVLGDEQYLAELPGARTTFGGPVWRAALAHPPAVGTPDPDRPAWLVFTSGSTGRPKGAVHTHRSLAAGAWGTVEGRSVPDADVYLTPFPMCHIAGYNVLVRHATGSTVVLPSRFRPAEFVAAVNAHRVRSCSLAPTMLHALVAYVQSHDDAAMPTLREVAYGAAPITADLIERAADVLGVDFHQGYGMTETAGNVTFLTPAEHRMGAQVLRTAGRPHSGVRVAIDGPEEVGEVLVDGPQLMAGYWDPTAGAVTPRTGWFRTGDVGRLDADGRLTIVDRSKDVIITGGENVSSREVEDALSTHPGVDMVAVVGVPDDYWGEAICAVVVAHPDRRPTAEELIDHVRERISAFKRPRHVLFVEQLPMTSNGKIAKDRVRHLARAATLGPAD
>NZ_AP022603.1|WP_085095467.1|3900510_3901308_+|isoprenyl-transferase
MEIIPPRLKEPMYRLYELRLRHELAQSRAQLPRHIAVLCDGNRRWARDAGYDDVSVGYRMGAAKIAEMLRWCAAEGIELATVYLLSTENLQRDPEELSALIEIITDVVEEICAPANRWSVRTVGDLELLGEEPARRLRQAVDGTAATATPGGLHVNVAVGYGGRQEIVDAVRSLLNKAIAGGATGEQLIEAVTADGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHWPAFRRVDFLRALRDYSQRNRRFGT
>NZ_AP022603.1|WP_085095481.1|3899663_3900521_-|hemolysin-III-family-protein
MISTVSQTTVKPCGAFRASARAGSRHRRCTLTAPTDRPSTSAASDRPLTQLDIDGFSADLPEAIAEGVAQFLGKPRARGWIHLYSAVIATIAGAALVAVSWSLKGVTAGLSTLLYTFTIVAMFTVSAVYHRVNWTSRTARTWMKRADHSMIFLFIAGSYTPFALLALPSNQGWVLFWIVWGGALAGVALKMLWPSAPRWLGVPLYILLGWVAAWFIGPIMDGAGVAAVVLLIVGGALYSIGGVLYALKWPNPWPTTFGHHEFFHACTAVAAICHYIAMWFAVFSG
>NZ_AP022603.1|WP_085095483.1|3898955_3899321_+|nuclear-transport-factor-2-family-protein
MPYVVDTEALVKRYLDTVATGTSADVAALYSEDATLEDPVGGGEVHIGRQAIQRFYTALDAAELSTELLSFRSGGHEAAFAFGITVGGAMRIEPIEVMTFDRDGLITSMKAYWSQADVTML
>NZ_AP022603.1|WP_085095469.1|3896947_3898945_+|thioredoxin-domain-containing-protein
MANLLADATSPYLRQHADNPVHWQQWSPDALAEAARRNVPILLSIGYAACHWCHVMAHESFEDDDVAAVANANFVCIKVDREERPDLDTIYMNATVALTGQGGWPMTCFLTPTGEPFFCGTYYPKAAFLQLLSAVTEAWTQRRDDVDAASGRIAEELRRMADGLPGGPPISAELCQHAVSAVLGAEDIRHGGFGGAPKFPPSSLLEALLREHERTGSAPALAAVERTATAMARGGIYDQLAGGFARYAVDIAWVVPHFEKMLYDNALLLNVYAHWARRTGSALAARIAGETADFLLRDLAEASGSGLFISSLDADADGREGSSYVWTPEQLAEVLGDEDGRWAAEFFTVTAAGTFEHGESVLQRLADPDTADEARLQRVRAALLAARGSRVQPGRDDKIVTAWNALAISGLLEAAVALERPDLLAAANRCADALLELHLRDGRLRRASLGGTVGGNDGVLEDYAALADALLALYQHDGDPARLAAATGLLDTALAHFADEANPGGWFDVADDAEQLLMRPATATDDATPSGASLITGALLSAAHLVDVAERYEQAAAASLQRYSALLSRAPRAAGWWLAVAQAALTGPLQIAVACDDPGSALLAEARRLAPGGAVVVGGPRDSMPLLADRDRIDGADAAYVCRGRICDLPVTTPQGLAAALSPPV
>NZ_AP022603.1|WP_085095471.1|3896579_3896876_+|hypothetical-protein
MNGYVMTAMMLLAEEGPRNSGPDFGKASPIGLLFLVLLLISVLLLGKSMTKQLRKVPESFDDVPEADPELCKRAKKLRQSQPAEESDEVADVESKPAD
>NZ_AP022603.1|WP_085095473.1|3895719_3896583_+|mycothiol-conjugate-amidase-Mca
MSELRLMAVHAHPDDESSKGAATTARYAAEGHRVLVVTLTGGERGDILNPAMDRPDVRERVAAVRRQEMARAAEILGVEHSWLGFLDSGLPEGDPLPPVPEGSFAAIPLEGPLERLVTLVRAFRPHVMTTYDENGGYPHPDHIRCHEVSVAAYEAAADHLRFPGAGDPWSVAKLYYNHGFLRERMQLLQDEFARNGRTGPFASWLERWDPEHDHMARRVTTRIECADYFPQRDDALRAHATQIDPTGHFFTAPLEWQRRLWPTEEFELARSRVPVSLPETDLFEGVQ
>NZ_AP022603.1|WP_085095475.1|3895141_3895579_-|DUF4307-domain-containing-protein
MSDQAAIPPADRYGRRRRTPASRRRLAIGLTVLVLVLGVLIAVEGYRKLGGGDVSGSLAAYQLIDDQTAEVTLTVTRKDPSRPVVCIARARSKDGTETGRREILVGPSTDATVQVVMLVKTSKPPVTGDAYGCGTVIPSYLVAPS
>NZ_AP022603.1|WP_085095457.1|3905941_3907150_+|DUF885-domain-containing-protein
MSPEVLIREFLLLGLRFDRIEDGYVDSFTGDPALRRQVADEPDPVPTDLVKQARYLLDALPGVPLDEQFTAMRAEYLRAHLRALACAGRKFAGEQVGFVEEVRDYFDVTITKGDPETYRQAHRSLEEALGGSGPLTERIAAYRAGEEIAPQRLGEAIDAFSSALRDRVRASYPLPDTETVEYEIVTDKPWSGFNYYRGNYTSTVAVNADLKQQMSNLPRLVAHESYPGHHTEHCRKEAGLVAGLGQAEQTIFLVNTPQCLMAEGLADLALYAAVGPEWGGWAAEIYADLGLRFDGQRAQAVSAAMAGLADVRQDAALMLHDEHRDPDDVVAYLRRWLLVDETRARHMLRFLSSPLWRAYTSTYVEGYRLLRGWLDDRPAGMDLAERFRVLLDEPLIPSTLPR
>NZ_AP022603.1|WP_085095455.1|3907540_3908995_+|glycine-hydroxymethyltransferase
MTADSTVSTQGADYAATASTAYQNILQVIETVEPRIAAATRKELADQRESLKLIASENYASPAVLLTMGTWFSDKYAEGTVGHRFYAACQNVDTVEALAAEHARELFGAPYAYAQPHSGIDANLVAYWAILATRVETPGLAELGAKHVNDLSEADWEKLRAKLGNQRLMGMSLDTGGHLTHGFRPNISGKMFHQRSYGTDPVTGLIDYDALAAAAREFKPLVLVAGYSAYPRRVNFAKMREIADEVGATLMVDMAHFAGLVAGKVFTGDEDPVPHAHVTTTTTHKSLRGPRGGLVLATEEYAPAVDKGCPMVLGGPLSHVMAAKAVALAEARRPEFRSYAQAVADNAKSLADGFLSRGGNLVTGGTDNHLVLLDVTSFGLTGRQAESALLDAGIVTNRNAVPADANGAWYTSGIRFGTPALTTRGFGADDFDRVAELVVEVLSNTTADGSSKAKYTVADGVADRVRAASGELLDANPLYPGLVL
>NZ_AP022603.1|WP_085095453.1|3909135_3909960_+|acyl-ACP-desaturase
MAVFPEPNTLTLELEPVVAENMQRHLGTEEIWFAHDYVPFDEGRNFAMLDGVDWEPSQQTLPQHVVDALEILLIDKDNMHGVHRELVEHFILRDQWGRFIGRWTAEEHLHAIVLRNYLMVTRNCDANANEDVRIDHVMNTGYRADQYSQVETLVFMTFYERSRARFCRNLAAQIDEPTLKSLIERIAADEDRHELFFANLVTHLLGTAREETVAAIAARARELEVVGADIKAYGDKRDNVAAAGIFNAEILRQIIAERIEAWGLAEEPALKEFI
>NZ_AP022603.1|WP_085095451.1|3910148_3911477_+|PhoH-family-protein
MTDSPVSRDNIRTYVLDTSVLLSDPWALMRFAEHEVVVPLVVISELEAKRHHHELGWFAREALRLFDDLRLEHGRLDQPIPVGAEGGTLHVELNHSDPSVLPAGFRSDSNDSRILTCAANLAAEGKRVTLVSKDIPLRVKAGAVGLPADEYRAQDVVPSGWTGMTELDVEPEDIDQIFADGDIELAEARDLPCHTGIRLLGGSSHALGRVNADKRVQLVRGDREVFGLRGRSAEQRIALDLLLDESVGIVSLGGKAGTGKSALALCAGLEAVLERRTQRKVVVFRPLYAVGGQELGYLPGSESEKMGPWAQAVFDTLEGLASPAVLDEVASRGMLEVLPLTHIRGRSLHDSFVIVDEAQSLERNVLLTVLSRLGTGSRVVLTHDVAQRDNLRVGRHDGVAAVIEKLKGHPLFAHITLLRSERSPIAALVTEMLEEISPNALP
>NZ_AP022603.1|WP_109750482.1|3911801_3912653_+|polysaccharide-deacetylase-family-protein
MAIGAVSIVLVVVVGVLAGRVTRDSPAEAQAGVDCGAVKCIALTFDDGPGPYTDRLLQILKDNDARSTFFLIGNKVAANPEGAKRIAEAGMEVGSHTWEHPNMTTIPAEEIPAQFRRASDAIEQATGARPKLVRTAGGLINDEVLAEAGRQGLADINWDVIPFDWANDANTDATRYMLMTQIKPNSVVLFHDTYSSTVDLVQQFIPVLKANGYHLVTVSQLAGEREPGTSYGSRENGPPVNELKDIPPQDIPSLPATPSPPPMPNFPITDIPGANSGGPNNGA
>NZ_AP022603.1|WP_085095447.1|3912722_3913952_-|YncE-family-protein
MADPDQPTELLTSSSGEPATVQPSRSPLRHPATIAAALLLVLVVAVAVVIAGRLGGDHQDAGPARLAYTAAATAAVTVAGGANGVTVDPGSRWLYVAGTSPSTGLGTLSVIDADTEKITRTIEVGKYPGDIAVGQGGRTVYVAIRDGVSVVDLDAGAVTGTIKFEQRPSGLAVLGRDLYVAHPSSVDITELGPGDKLDTAFPNLSIIDTVTNKVITTLSTGGPDALALAADPQRSALYAVDLTNEITAVDARMRNVTKRFRIDPAKLVGIMGLAVDRNRLYAAGVDTAGGQGSLTDITGGIPAAPITMPGPLGQIAIDSDARRAYVLIPAVTPLPDSTGGQAAEEARDGGLAVVDLDAKTVTDIVEVGADPRSVAVDATTHTAYVANADDTVSVIKPGSIKPASIKPAP
>NZ_AP022603.1|WP_085095445.1|3914150_3915551_-|class-II-fumarate-hydratase
MTDGEYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNKDLGLLDPAKADAIVAAAGEIADGLHDDQFPIDVFQTGSGTSSNMNANEVIASICAANGVTVHPNDDVNMSQSSNDTFPTATHIAATEAAVRDLIPALEVLHESLAAKAKQWRTTVKSGRTHLMDAVPVTLGQEFGGYARQIEAGIERVRASLPRLGELAIGGTAVGTGLNAPDGFGPKVVEVLTTETGVAELRPAVDAFEAQAARDGLVEVSGALKTIAVSLTKIANDVRWMGSGPLTGLGEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAVTVGGLSGAFELNVYIPMMARNVLESFRLLANVSKLFAAKCIDGLVANEEHLRTLAESSPSIVTPLNSAIGYEEAAKVAKQALAEKKTIRQTVIDRGLIGEKLSEEELDRRLDVLAMAKVRDGE
>NZ_AP022603.1|WP_085095443.1|3915615_3916671_-|class-II-fructose-bisphosphatase
MSDAASSTPTPTRRREAPDRNLALELVRVTEAGAMAAGRWVGRGDKEGGDGAAVDAMRELVNSVSMRGVVVIGEGEKDNAPMLYNGEEVGNGDGPDCDFAVDPVDGTTLMSKGMPNAISVLAVAERGAMFDPSAVFYMNKIAGGPDVAEFIDITSPIAANIQRIAKVRKASVSDVTVCILDRPRHAKLMAAVREAGARIRLISDGDVAGAISACRPESGTDLLVGIGGTPEGIIAAAAIRCMGGEIQATLAPTDDEERQRAIDRGHDLDRVLTTKDLVAGENVFFCATGVTDGDLLDGVRFFGGGCTTQSIVMRSKSGTVRMIEAYHRLSKLNEYSAVDFTGDKTAAYPLP
>NZ_AP022603.1|WP_085095442.1|3916713_3917454_+|DUF4245-domain-containing-protein
MGLDTGGVSTPPPQPAEPDPGAPGAVETTPAAVPAPEARPAPKAAKNRLFQDGRDMFWSMAPLVIACVVLAGMLGQCSFQPTGPEPGPVPRYDVSAALGSDAQVLGFPVRLPTVPEDWQPNSGARDGIDSGRVDPADGQRKRALLSRVGYITPRGVYLSVTQSNADEDRLVAAVHPELYPTGSQDIDGVRWVVYQGSERGEPVWSARLDSAAGPTQVAITGAGNPDEFRTLARAVQDAPPLPAKAK
>NZ_AP022603.1|WP_085095440.1|3917504_3918299_+|dienelactone-hydrolase-family-protein
MTNSTAVFPGWTCGPFTGGGFTYDVYRKGSGPGVVLIPEMPGLHPGVWELGNHLAGAGFAVAAPSLFGTPGAGIGPGAALVLARACVAKEFAAFATNKKRPITDFIRALARDLNEQTPGRGVGVIGMCFTGGFALAAAVDDAVLAPVLSQPSLPIGVSPAIRRDPGVSEDELATVQRRTETDGLCALGLRFSEDQMAPRERFRTLKDRLGDAFEVIEINSAPGNPDGLNRFAHSVLTDQVVYKPDHPTFQARERVVEFLTERLK

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Crispr_ID: NZ_AP022603_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022603_19

3995636-3995715

Orphan

Consensus_repeat	Method
GCCGGGAACGGGTCCGGCCGGGGACGGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022603_19

>merge|NZ_AP022603|19|3995636-3995715|CRISPRCasFinder
GCCGGGAACGGGTCCGGCCGGGGACGGGGGGCGAGCCGGGAGCGGCGTCCTGCCGGGAGCGGGGTCGAGCCGGGAACGGG

>NZ_AP022603|19|17|3995636-3995715|CRISPRCasFinder
GCCGGGAACGGGTCCGGCCGGGGACGGGG	GGCGAGCCGGGAGCGGCGTCCT
GCCGGGAGCGGGGTCGAGCCGGGAACGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022603.1\|WP_085092535.1\|4007309_4008254_-\|2,3,4,5-tetrahydropyridine-2,6-dicarboxylate-N-succinyltransferase	unknown	unknown	gnl\|CDD\|274635
NZ_AP022603.1\|WP_085092488.1\|3993937_3994351_+\|group-III-truncated-hemoglobin	unknown	unknown	gnl\|CDD\|381257
NZ_AP022603.1\|WP_085092508.1\|3989428_3991990_+\|bifunctional-FO-biosynthesis-protein-CofGH	unknown	unknown	gnl\|CDD\|236422
NZ_AP022603.1\|WP_085092541.1\|3999254_3999578_+\|ferredoxin-family-protein	unknown	unknown	gnl\|CDD\|224069
NZ_AP022603.1\|WP_085092487.1\|3994421_3994862_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085092493.1\|3988258_3989230_-\|pirin-family-protein	unknown	unknown	gnl\|CDD\|224655
NZ_AP022603.1\|WP_085092536.1\|4005271_4006696_+\|acyl-CoA-synthetase	unknown	unknown	gnl\|CDD\|236096
NZ_AP022603.1\|WP_085092494.1\|3986861_3988145_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085092538.1\|4002426_4004058_+\|L-glutamate-gamma-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143441
NZ_AP022603.1\|WP_085092533.1\|4009441_4009999_+\|TIGR00730-family-Rossman-fold-protein	unknown	unknown	gnl\|CDD\|129813
NZ_AP022603.1\|WP_085092491.1\|3992545_3992890_+\|ferredoxin-family-protein	unknown	unknown	gnl\|CDD\|224069
NZ_AP022603.1\|WP_085092539.1\|4000695_4002342_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225306
NZ_AP022603.1\|WP_085092537.1\|4004057_4005005_+\|proline-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223580
NZ_AP022603.1\|WP_109750361.1\|3999613_4000699_+\|succinyldiaminopimelate-transaminase	unknown	unknown	gnl\|CDD\|236119
NZ_AP022603.1\|WP_085092489.1\|3993503_3993941_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022603.1\|WP_085092507.1\|3995023_3995437_+\|group-III-truncated-hemoglobin	unknown	unknown	gnl\|CDD\|381257
NZ_AP022603.1\|WP_085092492.1\|3992015_3992492_-\|DUF309-domain-containing-protein	unknown	unknown	gnl\|CDD\|377120
NZ_AP022603.1\|WP_085092490.1\|3992886_3993507_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225222
NZ_AP022603.1\|WP_085092534.1\|4008371_4009445_+\|succinyl-diaminopimelate-desuccinylase	unknown	unknown	gnl\|CDD\|237264
NZ_AP022603.1\|WP_085092542.1\|3996870_3998895_-\|NADPH-dependent-2,4-dienoyl-CoA-reductase	unknown	unknown	gnl\|CDD\|239240

Protein	Function_ID	Function_description	E-value
NZ_AP022603.1\|WP_085092535.1\|4007309_4008254_-\|2,3,4,5-tetrahydropyridine-2,6-dicarboxylate-N-succinyltransferase	gnl\|CDD\|274635	TIGR03535, DapD_actino, 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase. This enzyme is part of the diaminopimelate pathway of lysine biosynthesis. This model represents a clade of the enzyme specific to Actinobacteria. Alternate name: tetrahydrodipicolinate N-succinyltransferase.	0
NZ_AP022603.1\|WP_085092488.1\|3993937_3994351_+\|group-III-truncated-hemoglobin	gnl\|CDD\|381257	cd08916, TrHb3_P, Truncated hemoglobins (TrHbs, 2/2Hb, 2/2 globins); group 3 (P). The M- and S families exhibit the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments. Truncated hemoglobins (TrHbs, 2/2Hb, or 2/2 globins) or the T family globins adopt a 2-on-2 alpha-helical sandwich structure, resulting from extensive and complex modifications of the canonical 3-on-3 alpha-helical sandwich that are distributed throughout the whole protein molecule. They are classified into three main groups based on their structural properties and named after Mycobacterium sp. genes glbN, glbO, and glbP: TrHb1s (N), TrHb2s (O) and TrHb3s (P). TrHb3s include Campylobacter jejuni Ctb, encoded by Cj0465c, which may play a role in moderating O2 flux within C. jejuni.	6.03253e-44
NZ_AP022603.1\|WP_085092508.1\|3989428_3991990_+\|bifunctional-FO-biosynthesis-protein-CofGH	gnl\|CDD\|236422	PRK09234, fbiC, FO synthase; Reviewed.	0
NZ_AP022603.1\|WP_085092541.1\|3999254_3999578_+\|ferredoxin-family-protein	gnl\|CDD\|224069	COG1146, COG1146, Ferredoxin [Energy production and conversion].	1.92171e-11
NZ_AP022603.1\|WP_085092539.1\|4000695_4002342_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225306	COG2508, COG2508, Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism].	1.17413e-24
NZ_AP022603.1\|WP_085092536.1\|4005271_4006696_+\|acyl-CoA-synthetase	gnl\|CDD\|236096	PRK07787, PRK07787, acyl-CoA synthetase; Validated.	0
NZ_AP022603.1\|WP_085092492.1\|3992015_3992492_-\|DUF309-domain-containing-protein	gnl\|CDD\|377120	pfam03745, DUF309, Domain of unknown function (DUF309). This domain is found in eubacterial and archaebacterial proteins of unknown function. The proteins contain a motif HXXXEXX(W/Y) where X can be any amino acid. This motif is likely to be functionally important and may be involved in metal binding.	8.66109e-23
NZ_AP022603.1\|WP_085092538.1\|4002426_4004058_+\|L-glutamate-gamma-semialdehyde-dehydrogenase	gnl\|CDD\|143441	cd07123, ALDH_F4-17_P5CDH, Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17. Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), families 4 and 17: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), also known as ALDH4A1 in humans, is a mitochondrial homodimer involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Also included in this CD is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences.	0
NZ_AP022603.1\|WP_085092533.1\|4009441_4009999_+\|TIGR00730-family-Rossman-fold-protein	gnl\|CDD\|129813	TIGR00730, LOG_family_protein_YJL055W, TIGR00730 family protein. This model represents one branch of a subfamily of proteins of unknown function. Both PSI-BLAST and weak hits by this model show a low level of similarity to and suggest an evolutionary relationship of the subfamily to the DprA/Smf family of DNA-processing proteins involved in chromosomal transformation with foreign DNA. Both Aquifex aeolicus and Mycobacterium leprae have one member in each of two branches of this subfamily, suggesting that the branches may have distinct functions. [Hypothetical proteins, Conserved].	2.63064e-63
NZ_AP022603.1\|WP_085092491.1\|3992545_3992890_+\|ferredoxin-family-protein	gnl\|CDD\|224069	COG1146, COG1146, Ferredoxin [Energy production and conversion].	9.81395e-12
NZ_AP022603.1\|WP_085092493.1\|3988258_3989230_-\|pirin-family-protein	gnl\|CDD\|224655	COG1741, COG1741, Pirin-related protein [General function prediction only].	1.83631e-66
NZ_AP022603.1\|WP_085092537.1\|4004057_4005005_+\|proline-dehydrogenase-family-protein	gnl\|CDD\|223580	COG0506, PutA, Proline dehydrogenase [Amino acid transport and metabolism].	8.76171e-64
NZ_AP022603.1\|WP_109750361.1\|3999613_4000699_+\|succinyldiaminopimelate-transaminase	gnl\|CDD\|236119	PRK07865, PRK07865, N-succinyldiaminopimelate aminotransferase; Reviewed.	0
NZ_AP022603.1\|WP_085092507.1\|3995023_3995437_+\|group-III-truncated-hemoglobin	gnl\|CDD\|381257	cd08916, TrHb3_P, Truncated hemoglobins (TrHbs, 2/2Hb, 2/2 globins); group 3 (P). The M- and S families exhibit the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments. Truncated hemoglobins (TrHbs, 2/2Hb, or 2/2 globins) or the T family globins adopt a 2-on-2 alpha-helical sandwich structure, resulting from extensive and complex modifications of the canonical 3-on-3 alpha-helical sandwich that are distributed throughout the whole protein molecule. They are classified into three main groups based on their structural properties and named after Mycobacterium sp. genes glbN, glbO, and glbP: TrHb1s (N), TrHb2s (O) and TrHb3s (P). TrHb3s include Campylobacter jejuni Ctb, encoded by Cj0465c, which may play a role in moderating O2 flux within C. jejuni.	1.7573e-36
NZ_AP022603.1\|WP_085092490.1\|3992886_3993507_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	1.24155e-24
NZ_AP022603.1\|WP_085092534.1\|4008371_4009445_+\|succinyl-diaminopimelate-desuccinylase	gnl\|CDD\|237264	PRK13007, PRK13007, succinyl-diaminopimelate desuccinylase; Reviewed.	0
NZ_AP022603.1\|WP_085092542.1\|3996870_3998895_-\|NADPH-dependent-2,4-dienoyl-CoA-reductase	gnl\|CDD\|239240	cd02930, DCR_FMN, 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the flavin and iron-sulfur cofactors. Metabolism of unsaturated fatty acids requires auxiliary enzymes in addition to those used in b-oxidation. After a given number of cycles through the b-oxidation pathway, those unsaturated fatty acyl-CoAs with double bonds at even-numbered carbon positions contain 2-trans, 4-cis double bonds that can not be modified by enoyl-CoA hydratase. DCR utilizes NADPH to remove the C4-C5 double bond. DCR can catalyze the reduction of both natural fatty acids with cis double bonds, as well as substrates containing trans double bonds. The reaction is initiated by hybrid transfer from NADPH to FAD, which in turn transfers electrons, one at a time, to FMN via the 4Fe-4S cluster. The fully reduced FMN provides a hydrid ion to the C5 atom of substrate, and Tyr and His are proposed to form a catalytic dyad that protonates the C4 atom of the substrate and completes the reaction.	0

>NZ_AP022603.1|WP_085092507.1|3995023_3995437_+|group-III-truncated-hemoglobin
MADRDDVYLLLSTFYGRALVDALLQDPFEDIRAKGLESHLPVMCDFWETMLFRARKYRGSALTVHKPIHTAHPLTSQHFIRWLSLWMETVDELFAGPIAEQAKIIGRRTAWAMHRALVGHDADDLDDFVDREALIIR
>NZ_AP022603.1|WP_085092487.1|3994421_3994862_+|hypothetical-protein
MYWSSIAVATTFTWLGMVLAISFIEAPLKFRAPKVTLQIGLGVGRLVFRALNSAEVALTLILLVALVMSRPPMFAVAALGVAVAMLVTQIAGVRPFLAKRSDAVLADPDGGVGLKRSKAHFAYSGLEIIKVSALVVGGFALLAGWS
>NZ_AP022603.1|WP_085092488.1|3993937_3994351_+|group-III-truncated-hemoglobin
MSGLTDIASRDDLYRLLSRFYGRALVDELLEDPFEEVRAMGLEAHLPVMCDFWETLLFGAPSYRGSPLPVHLAVHDRHPLNGAHFVRWLTLWQSTVDEMFAGPVAEATKANGRRIAWNMHRRLTGRDAAELDALVGV
>NZ_AP022603.1|WP_085092489.1|3993503_3993941_+|hypothetical-protein
MSTGSAIIAAASFFWLGMVGAISFVEAPLKFRAPGVTLQIGLGIGRMVFRALNSIEVVLAVLIVVAAVLDPPGCLVLVGVAVAVLALAAQLLAVRPRLIRRSNAVLADQTGAVAASRSRAHYWYLAGELVKIAGLLTAGIAVLAG
>NZ_AP022603.1|WP_085092490.1|3992886_3993507_+|helix-turn-helix-domain-containing-protein
MRAAGRRGDVLAMLRAADGPRSITAIADQLDVHPNTVRFHLDALLESGQVQRSAPTVTGPGRPAQLFVATAGMDPGGPRHYRLLAEALTESVARGPDPVRQAQLAGEVVGLRLGAARGDGGNRPVAQLVGLLDDLGFAPEPDDARIRLRHCPFLEVARAHPEVVCPLHLGLMQGAMQAWAAPMSVATLTPFAQPDLCVAELTGVGR
>NZ_AP022603.1|WP_085092491.1|3992545_3992890_+|ferredoxin-family-protein
MAYVIAQPCADVKDKACVEECPVDCIYEGARALYIHPDECVDCGACEPVCPVEAIYYEDDLPEEYVGYQDDNAAFFAETLPGRDAPLGSPGGAAKLGAVDADGPLVAGLPPQEQ
>NZ_AP022603.1|WP_085092492.1|3992015_3992492_-|DUF309-domain-containing-protein
MPDTPRRDRDDDGRPRNARPRDALGRPLPPGSQGVPQLPEDLNLSPDETLALAQQLLDDGRAFSAHEVFEAAWKSGPDDERSLWQGLAQLAVGITHIQRGNPTGGQSLLRRSAKRLSEAEPRYGIDVTALIGFAGALADDLAAGTEIPAARLRPLLQR
>NZ_AP022603.1|WP_085092508.1|3989428_3991990_+|bifunctional-FO-biosynthesis-protein-CofGH
MPLGAAAPSAAVPSAAAMRRVLRRARDGVALNVDEATIALAARGEDLADLCASAARVRDAGLEAAGRRGPTGRLPVSYSRKVFIPVTHLCRDTCHYCTFVTVPGKLRAAGAGMYLEPDEILDIARRGADLGCKEALFTLGDRPEARWPEARQWLDERGYDSTLDYLRAMSIRVLEETGLLPHLNPGVMSWSELSRLKPVAPSMGMMLETTSTRLFETKGEAHHGSPDKDPAVRMRTLVDAGRLSIPFTTGLLIGIGENLRERAETIHAIRRVHKEFGHIQEVIVQNFRAKPDTAMRAVPDAGIEDFLAAIAVTRLVLGPAMRVQAPPNLVSAAECRALIGAGIDDWGGVSPLTPDHVNPERPWPALDSLAEMTGETGYDLVQRLTAHPKYVHGGAAWIDPRVRAHVDALADPDTGWAREVNPVGIPWQEPDEATQSLGRTDLHAAIDADGRLTETRSDIDSAFGDWESVRDRVHELAARAPERVDTDVLAALRSAERDPGGCSDDEYLALATADGPALEAVAALADSLRRDVVGDEVTYVVNRNINFTNICYTGCRFCAFAQRKGDADAYSLSAEEVGERAWEAHVAGATEVCMQGGIDPELPVTGYADLVRAVKARVPSMHVHAFSPMEIANGVTRSGISLREWLIGLREAGLGSIPGTAAEILDDEVRWVLTKGKLPTSEWIEIVSTAHEVGLRSSSTMMYGHVDTPAHWVGHLNVLRGIQDRTGGFTEFVPLPFVHQSAPLYLAGAARPGPTHRDNRAVHALARIMLHGRIPNIQTSWVKLGAERTRVMLRGGANDLGGTLMEETISRMAGSEYGSAKTVAELVDIAEGIGRPARQRTTTYGNCEAHTGA
>NZ_AP022603.1|WP_085092493.1|3988258_3989230_-|pirin-family-protein
MSNLDSSPVETVCGPSSAPAVELLRPREVPLGGPRAMMVRRTLPQRQRSLIGAWCFADHYGPQDVRSTGGMDVAPHPHTGLQTVSWLFRGEIEHRDSNGIHAMVRPGELNLMTAGAGICHSEVSTPATTVLHGLQLWVALPDAARNTAPDFAHHVPPPVRVDGVTLRVFLGELAGDRSPVHTFSPLLGAQLDLPGRTAIQLEVDESFEHGVLLDRGVIEVADQPLESGDLTYHGPGRRELTIRNTGEQPARAILLGGAPLHEKLLMWWNFVGRSHDEIVEYRRLWESHDKRFGSVEGYLGSPARLPAPPLPTTRLRPRSTGGR
>NZ_AP022603.1|WP_085092494.1|3986861_3988145_-|hypothetical-protein
MVTRISYRSLLTAGIAGVTAAALVVTPAITPPPAAEQQPVSVSVPVRHTAATVPMVLNSPLGPASAIVPPTTPPAIANLAVPGTTSAASDINAAIKSIYTWGEKWVSWGFDVATWAVSWVPWIGWFAGQIPILYDFGEAIVESIVFNLDDWIFGPMSFGTGLSNVVDDTGQAIRKLARDEINWLTGWLPPLPPLPPIGGSAARATTAGPLAAVQSSLSELTEKITALATKAGISPKLPTEFTAAGFTAAGPESVDTTLAKLPVLGELGAAVTTLQQAVGVQKAKPQAAAEDPPADAKIDADEPPADAAEATTDSDARPDKPLRRLLAINPFSAKRAGTAGPLRLANRGQDRATAAVLGEKSGEKPDAASGQLADSQDKGAPETGAAGSGASPKQPSSTGAKGLNGVTKAAESLKRAFSGKRDSAGSR
>NZ_AP022603.1|WP_085092542.1|3996870_3998895_-|NADPH-dependent-2,4-dienoyl-CoA-reductase
MTNPYPKLLSPLDLGFTTLKNRVVMGSMHTGLEDRARDTGRLAAYFAERARGGVGLIITGGYAPNRTGWLLPFAAEMLSSGDARRHRRITAAVHDEGGKILLQVLHAGRYAYHPLSASASALKAPINPFRPRALSSRGVEETIDDFVRCALLAQEAGYDGVEIMGSEGYLLNQFLAPATNRRTDRWGGSARNRRRLPVEIVRRTREAVGADFIVDYRISLADYVENGQSWDEILRLATEVEEAGATLLNSGFGWHEARVPTIVTSVPSGAFVDISSAVAEQVQIPVVASNRINMPEAAEQILADTHVQLISMARPMLSDPDWVNKAAADRAAEINTCIACNQACLDHAFVHKKVSCLLNPRAGHETRLVLAPTRVTRTVAVVGAGPAGLATAVSAAERGHRVTLFDANEHIGGQFDMARRIPGKEEFNETIRYFTTMLAKYDVDVRLGVRVGAEELTGFDEVVLATGVTPRMPAIPGIEHPMVLSYPEAIYGVREVGKRVAVIGAGGIGFDVSELLTTDESPTLNLKEWKAEWGAADPPEARGALTAPLPAPPAREVFLLQRTKGPQGRRLGKTTGWVHRASLKAKGVQQLSEVNYERIDDDGLHISFGEKRQRPRVLAVDNVVICAGQESVRELEDALRSRGVRPHVIGGAAIAAELDAKRAIKQGTELAAQL
>NZ_AP022603.1|WP_085092541.1|3999254_3999578_+|ferredoxin-family-protein
MTYVIAEPCVDVKDKACIEECPVDCIYEGARMLYIHPDECVDCGACEPVCPVEAIFYEDDVPDEWSGYIQFNADFFEELGSPGGASKVGQTDNDPQGVKDLEPKGEA
>NZ_AP022603.1|WP_109750361.1|3999613_4000699_+|succinyldiaminopimelate-transaminase
MSARLPVFPWDTLAEATATAWAHPDGIVDLSVGTPVDPVAPLIQQALAGAGFEPGYPTTAGTAALRAAIVGSLARRYGITGLPEDAVLPVIGTKELIAWLPTLLGLGAADLVVVPELAYPTYDVGARLAGTRVLAADSLTQIGPQRPALLYLNSPANPTGRVLGIDHLRKVVGWARERGVIVASDECYLGLAWDAEPLSVLHPSVCDGDHTGLLAIHSLSKTSSLAGYRAGFVAGDRALVAELLAVRKHAGMIVPTPVQAAMVAALDDDEHEVLQRQRYAARRARLLPAVTAAGFTVDHSEAGLYLWASRDEPCRDTVDWLAARGILAAPGEFYGPRGARHVRMALTATDQRIDAAVARLV
>NZ_AP022603.1|WP_085092539.1|4000695_4002342_-|helix-turn-helix-domain-containing-protein
MTSAGVSLGRLLLALDATVVSLIEAPRGLDLPVASSALIDADDVRLGLSAGTGSADIFFLLGIPGEEVLRWIDRSAGDGVPTAIFLKEPGEQVIARAAAAGIAVVAVDPRARWERLYRLVDHVLSHHRDHDDPQYDPSTDLFGLAQSIADRAHGLVTIEDESSHVLAYSASSADADELRRLSILGRAGPVEHLQRLGQWGILDALRTRPDIVRVPARPELGLRPRVAIGIQLPAADPRRAPAFAGTIWVQQGARALAEDVEDVLRGAAVLAGRIMARLAAAPSTHALRVQQLLGLRAAGPGEPDDPVAIARELGIVADGRAAVIGVQSATAHARLADVMALSASAFHPEVQVASNGSRIYLLFPATGKPAAVTSWVRGAVESLRTELGLQLHAVVTAPVAGLGQAAAARAEVDRVLDSAGRHPGALRPVTSLAEARTTVLLDEIVTLIAADDRLIDPRVDELRAKDPMLADTLRVYLDSFGEIAAAAAQLHVHPNTVRYRVRRIEQLLGTPLADPDVRLVLSLSLRATQPEAGHPTLSRRAPDSRPKA
>NZ_AP022603.1|WP_085092538.1|4002426_4004058_+|L-glutamate-gamma-semialdehyde-dehydrogenase
MDAITQVPGPYNEPVHDYAPGSPERARLQTALRDLQAAGPIELPHVIAGRHTMGDGARIDVVQPHAHAKVLGTLTNAGHDEARAAVAAAMAARADWAALPFDDRAAVFLRAADLLAGPWRERIAAATMLGQSKTAYQAEIDAPCELIDFWRFNVAFARDILADQPASSPGVWNRTDYRPLDGFVYAITPFNFTAIAGNLPTAPALMGNTVVWKPSITQGFAAYLTMQLLEEAGLPPGVINLVTGDGLAVSEVVLADPRLAGIHFTGSTATFHRLWREVGANIDRYQGYPRLVGETGGKDFVVAHPSAAPEVLRTALIRGAFDYQGQKCSAASRAFIPRSVWNLMGDDLLCAVDDLSYGDVTDLSNFGGAVIDERSFAKQVAAIERAKSAPGVTIGAGGGYDDSVGYFVRPTVLVSEDPTGQEFATEYFGPILAVHVFPDEQFEDILGVVDTGSAYALTGSIIAEDRYAVETASRALRFAAGNFYINDKPSGAVVGQQPFGGSRASGTNDKAGSSLNLLRWTSARSIKETLVPPRNHRYPHMGA
>NZ_AP022603.1|WP_085092537.1|4004057_4005005_+|proline-dehydrogenase-family-protein
MGLFGAAARPAILAAARSARLRRVSERLPVTRKVVHRFVPGETVADAVNAVAALRESGCYATVDFLGEDTVDPAAATATVQAYLQLLDALAARGPAGPRPLEVSLKLSALGQALPRDGEKIALDNARVICARAAEAGVWVTVDAEDHTTTDSTLGIVAELRAEWDWVGTVLQAYLKRTHADCRQLAGTRIRLCKGAYDEPESVAYRAAEQVSANYLDCLRVLMAGSGYPMVASHDPAIIAAVPGLAAQYGRGADDFEYQMLYGIRGSEQLRLVNNGAHVRVYVPFGTQWYGYFVRRLAERPANLTFFLRALAERA
>NZ_AP022603.1|WP_085092536.1|4005271_4006696_+|acyl-CoA-synthetase
MLLASLNPAAVAAGADLPDAVTIDGTTLSRSDLVGAATSVAERVAGLSRVAVLATPSVSTVLAVVGCLIAGVPVVPVPADVGATERAHMLTDSGAVAWLGEAPEQPGGLPHIPVRLYARSWHRYREPDPAAVALIIYTSGTTGLPKGVPMRRAQIAADIDALAAAWAWTADDVLVHGLPLFHVHGLVLGLLGSLRIGNRFVHTGKPTPQAYAAVAGTMYFGVPTVWSRVAADPESAAALRSARLLISGSAALPTPVFDRLVELTGHAPIERYGSTESMITLSTRVDGERRPGWVGLPLEGVSTRLVDEAGAAVPCDGETIGLLEVRGPMVFDGYLNRPDATAEAFDDGWYRTGDVAVIDADGMHRIVGRESVDLIKTGGFRVGAGEIETTLLGHPAVVEAAVVGVPDDELGQRIVAYVVAASDSSVTAEELTELVAQQLSAHKRPREVRFADALPRNAMGKVTKKQLIAEASTE
>NZ_AP022603.1|WP_085092535.1|4007309_4008254_-|2,3,4,5-tetrahydropyridine-2,6-dicarboxylate-N-succinyltransferase
MTGAFGIGVATLAADGSVLDTWFPAPELGSFGEAGTVRLSTAEAPAELVSLVGHDTDRGTETVLVQVVIADLADKAVDAHDVYLRLHLLSHRLVAPHGANMDGVFGLLTNVVWTNHGPCPVDGFETVRARLRRRGQVTVYGVDKFPRMVDYVLPAGVRIADADRVRLGAHLATGTTVMHEGFVNFNAGTLGTSMVEGRISAGVVVGDGSDIGGGASIMGTLSGGGSEVISVGKRCLLGANAGLGISLGDDCVIEAGLYVTAGTKVVLADGRTVKARELSGANNLLFRRNSVSGAVEVVARDGQGIALNEDLHAN
>NZ_AP022603.1|WP_085092534.1|4008371_4009445_+|succinyl-diaminopimelate-desuccinylase
MLDLHADPIDLTAALVDIRSESRDEKQLADAVEAALRAQTRGFEVIRNGDAVLARTNHGHRSRVLLAGHLDTVPIADNLPSRRDDEFLWGCGTSDMKAGDAVFLHLAATIAEPAHDLTLVFYDCEEIEASANGLGRIERELPDWLRADVAILGEPTGGYIEAGCQGTLRVVVAAAGTRAHSARSWMGDNAIHRLAPVLDRLAQYSAREVDIDGCVYREGLSAVRIDGGVAGNVIPDAAAVTVNFRFAPDRSPEQALAHVTEVFDGLDVTIELTDSAAGALPGLSQPAAAALVEAAGGAVRAKYGWTDVARFAALGIPAVNFGPGDPNLAHRRDERVELALITDGTAMLRSYLTGGPA
>NZ_AP022603.1|WP_085092533.1|4009441_4009999_+|TIGR00730-family-Rossman-fold-protein
MSRPWAVCVYCASGPGDPELLALADAVGRAIAERGWSVISGGGSVSAMGALADGARARGGHTVGVIPKALLHREVADVHADELLVTDTMRQRKQIMEDRADAFLALPGGIGTLEELFEAWTAGFLGMHDKPVVILDPGGHYDGLMSWLQGLVGTGYVAQSAIDALPVVRDLELALQLCAPPPAAH

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Crispr_ID: NZ_AP022603_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022603_20

4017562-4017664

Orphan

Consensus_repeat	Method
CTCACCTGTGTACGCGCCACGCCGTTGGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022603_20

>merge|NZ_AP022603|20|4017562-4017664|CRISPRCasFinder
CTCACCTGTGTACGCGCCACGCCGTTGGGGGCGTACACAGCTGAGCGCTGGCGCGGGAACGTTTTGCTGAGCTCTCACCTGTGTACGCGCCACGCCGTTGGGG

>NZ_AP022603|20|18|4017562-4017664|CRISPRCasFinder
CTCACCTGTGTACGCGCCACGCCGTTGGGG	GCGTACACAGCTGAGCGCTGGCGCGGGAACGTTTTGCTGAGCT
CTCACCTGTGTACGCGCCACGCCGTTGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022603.1\|WP_085100046.1\|4024050_4025562_+\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NZ_AP022603.1\|WP_085100032.1\|4022651_4023422_+\|RNA-polymerase-sigma-factor-SigE	unknown	unknown	gnl\|CDD\|236606
NZ_AP022603.1\|WP_085100036.1\|4021711_4022464_-\|O-methyltransferase	unknown	unknown	gnl\|CDD\|226607
NZ_AP022603.1\|WP_085092529.1\|4014051_4014630_+\|DNA-3-methyladenine-glycosylase-I	unknown	unknown	gnl\|CDD\|377025
NZ_AP022603.1\|WP_085100039.1\|4020080_4020980_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_AP022603.1\|WP_085092530.1\|4012731_4013685_+\|glucosyl-3-phosphoglycerate-synthase	unknown	unknown	gnl\|CDD\|237556
NZ_AP022603.1\|WP_085100049.1\|4020999_4021638_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|375436
NZ_AP022603.1\|WP_085092531.1\|4011859_4012735_+\|dihydropteroate-synthase	unknown	unknown	gnl\|CDD\|273657
NZ_AP022603.1\|WP_085092533.1\|4009441_4009999_+\|TIGR00730-family-Rossman-fold-protein	unknown	unknown	gnl\|CDD\|129813
NZ_AP022603.1\|WP_085100042.1\|4017745_4018420_-\|isoprenylcysteine-carboxylmethyltransferase-family-protein	unknown	unknown	gnl\|CDD\|224931
NZ_AP022603.1\|WP_085100022.1\|4026008_4027148_-\|Mrp/NBP35-family-ATP-binding-protein	unknown	unknown	gnl\|CDD\|378455
NZ_AP022603.1\|WP_085092534.1\|4008371_4009445_+\|succinyl-diaminopimelate-desuccinylase	unknown	unknown	gnl\|CDD\|237264
NZ_AP022603.1\|WP_068532479.1\|4014783_4014951_+\|DUF3117-domain-containing-protein	unknown	unknown	gnl\|CDD\|371461
NZ_AP022603.1\|WP_085100029.1\|4023529_4023949_+\|zf-HC2-domain-containing-protein	unknown	unknown	gnl\|CDD\|131504
NZ_AP022603.1\|WP_163742604.1\|4016283_4017498_+\|glucose-1-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|234846
NZ_AP022603.1\|WP_085092532.1\|4010041_4011823_+\|long-chain-acyl-CoA-synthetase	unknown	unknown	gnl\|CDD\|236217
NZ_AP022603.1\|WP_163742607.1\|4018440_4020084_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226089
NZ_AP022603.1\|WP_085100025.1\|4025571_4025973_+\|Sec-independent-protein-translocase-subunit-TatB	unknown	unknown	gnl\|CDD\|179538
NZ_AP022603.1\|WP_085092544.1\|4013743_4014055_+\|DivIVA-domain-containing-protein	unknown	unknown	gnl\|CDD\|274639
NZ_AP022603.1\|WP_085092543.1\|4014958_4016104_-\|glycogen-synthase	unknown	unknown	gnl\|CDD\|273997

Protein	Function_ID	Function_description	E-value
NZ_AP022603.1\|WP_085100046.1\|4024050_4025562_+\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	4.94041e-79
NZ_AP022603.1\|WP_085100032.1\|4022651_4023422_+\|RNA-polymerase-sigma-factor-SigE	gnl\|CDD\|236606	PRK09647, PRK09647, RNA polymerase sigma factor SigE; Reviewed.	8.57064e-126
NZ_AP022603.1\|WP_085100036.1\|4021711_4022464_-\|O-methyltransferase	gnl\|CDD\|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	5.71414e-62
NZ_AP022603.1\|WP_085092529.1\|4014051_4014630_+\|DNA-3-methyladenine-glycosylase-I	gnl\|CDD\|377025	pfam03352, Adenine_glyco, Methyladenine glycosylase. The DNA-3-methyladenine glycosylase I is constitutively expressed and is specific for the alkylated 3-methyladenine DNA.	1.08364e-99
NZ_AP022603.1\|WP_085100039.1\|4020080_4020980_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.81983e-88
NZ_AP022603.1\|WP_085092530.1\|4012731_4013685_+\|glucosyl-3-phosphoglycerate-synthase	gnl\|CDD\|237556	PRK13915, PRK13915, putative glucosyl-3-phosphoglycerate synthase; Provisional.	3.14688e-178
NZ_AP022603.1\|WP_085100049.1\|4020999_4021638_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|375436	pfam17933, TetR_C_25, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in Rv1219c of Mycobacterium tuberculosis. Structural studies indicate that the helix alpha 10 of the C-terminal end of Rv1219c forms a long arm feature, a feature which is unique in Rv1219c compared to some other members of the TetR family. Furthermore, it has been shown that substrate binding occurs in the C-terminal regulatory domain of Rv1219c.	5.09708e-55
NZ_AP022603.1\|WP_085092531.1\|4011859_4012735_+\|dihydropteroate-synthase	gnl\|CDD\|273657	TIGR01496, Dihydropteroate_synthase, dihydropteroate synthase. This model represents dihydropteroate synthase, the enzyme that catalyzes the second to last step in folic acid biosynthesis. The gene is usually designated folP (folic acid biosynthsis) or sul (sulfanilamide resistance). This model represents one branch of the family of pterin-binding enzymes (pfam00809) and of a cluster of dihydropteroate synthase and related enzymes (COG0294). Other members of pfam00809 and COG0294 are represented by model TIGR00284. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid].	7.08503e-99
NZ_AP022603.1\|WP_085092533.1\|4009441_4009999_+\|TIGR00730-family-Rossman-fold-protein	gnl\|CDD\|129813	TIGR00730, LOG_family_protein_YJL055W, TIGR00730 family protein. This model represents one branch of a subfamily of proteins of unknown function. Both PSI-BLAST and weak hits by this model show a low level of similarity to and suggest an evolutionary relationship of the subfamily to the DprA/Smf family of DNA-processing proteins involved in chromosomal transformation with foreign DNA. Both Aquifex aeolicus and Mycobacterium leprae have one member in each of two branches of this subfamily, suggesting that the branches may have distinct functions. [Hypothetical proteins, Conserved].	2.63064e-63
NZ_AP022603.1\|WP_085100042.1\|4017745_4018420_-\|isoprenylcysteine-carboxylmethyltransferase-family-protein	gnl\|CDD\|224931	COG2020, STE14, Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones].	5.56934e-20
NZ_AP022603.1\|WP_085100022.1\|4026008_4027148_-\|Mrp/NBP35-family-ATP-binding-protein	gnl\|CDD\|378455	pfam10609, ParA, NUBPL iron-transfer P-loop NTPase. This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.	1.43249e-113
NZ_AP022603.1\|WP_085092534.1\|4008371_4009445_+\|succinyl-diaminopimelate-desuccinylase	gnl\|CDD\|237264	PRK13007, PRK13007, succinyl-diaminopimelate desuccinylase; Reviewed.	0
NZ_AP022603.1\|WP_068532479.1\|4014783_4014951_+\|DUF3117-domain-containing-protein	gnl\|CDD\|371461	pfam11314, DUF3117, Protein of unknown function (DUF3117). This family of proteins with unknown function appears to be restricted to Actinobacteria.	4.7956e-23
NZ_AP022603.1\|WP_085100029.1\|4023529_4023949_+\|zf-HC2-domain-containing-protein	gnl\|CDD\|131504	TIGR02451, Anti-sigma-E_factor_ChrR, anti-sigma factor, putative, ChrR family. The member of this family from Rhodobacter sphaeroides has been shown both to form a complex with sigma(E) and to negatively regulate tetrapyrrole biosynthesis. This protein likely contains (at least) two distinct functional domains; several smaller homologs (excluded by the model) show homology only to the C-terminal, including a motif PxHxHxGxE. [Regulatory functions, Other].	1.61902e-05
NZ_AP022603.1\|WP_163742604.1\|4016283_4017498_+\|glucose-1-phosphate-adenylyltransferase	gnl\|CDD\|234846	PRK00844, glgC, glucose-1-phosphate adenylyltransferase; Provisional.	0
NZ_AP022603.1\|WP_085092532.1\|4010041_4011823_+\|long-chain-acyl-CoA-synthetase	gnl\|CDD\|236217	PRK08279, PRK08279, long-chain-acyl-CoA synthetase; Validated.	0
NZ_AP022603.1\|WP_163742607.1\|4018440_4020084_-\|ABC-transporter-permease	gnl\|CDD\|226089	COG3559, TnrB3, Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane].	1.70076e-139
NZ_AP022603.1\|WP_085100025.1\|4025571_4025973_+\|Sec-independent-protein-translocase-subunit-TatB	gnl\|CDD\|179538	PRK03100, PRK03100, Sec-independent protein translocase subunit TatB.	2.50919e-67
NZ_AP022603.1\|WP_085092544.1\|4013743_4014055_+\|DivIVA-domain-containing-protein	gnl\|CDD\|274639	TIGR03544, cell_division_initiation_protein_DivIVA, DivIVA domain. This model describes a domain found in Bacillus subtilis cell division initiation protein DivIVA, and homologs, toward the N-terminus. It is also found as a repeated domain in certain other proteins, including family TIGR03543.	3.58778e-08
NZ_AP022603.1\|WP_085092543.1\|4014958_4016104_-\|glycogen-synthase	gnl\|CDD\|273997	TIGR02149, glgA_Coryne, glycogen synthase, Corynebacterium family. This model describes Corynebacterium glutamicum GlgA and closely related proteins in several other species. This enzyme is required for glycogen biosynthesis and appears to replace the distantly related TIGR02095 family of ADP-glucose type glycogen synthase in Corynebacterium glutamicum, Mycobacterium tuberculosis, Bifidobacterium longum, and Streptomyces coelicolor. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0

>NZ_AP022603.1|WP_163742604.1|4016283_4017498_+|glucose-1-phosphate-adenylyltransferase
MRDAAHVLGIVLAGGEGKRLYPLTADRAKPAVPFGGGYRLIDFVLSNLVNARYLRICVLTQYKSHSLDRHISQNWRLSGLAGEYITPVPAQQRLGPRWYTGSADAIYQSMNLIYDEDPDYIVIFGADHVYRMDPAQMVDFHIACGAGATVAGIRVPRKEASAFGCIDADSSGRIRGFVEKPADPPGTPDDPEQTFVSMGNYVFTTKVLIDAIKADADDDHSDHDMGGDIIPRLVAEDMAAVYDFNDNQVPGATERDHGYWRDVGTLDAFYDAHMDLVSVHPIFNLYNRRWPIRGGAENLAPAKFVNGGAAMESVVGAGSIVSAASVRNSVLSSNVAIDDGAIVEGSVLMRGVRVGRGAVVRHAILDKNVVVGPGEMVGVDLERDRERFSVSSGGVVAVGKGVWI
>NZ_AP022603.1|WP_085092543.1|4014958_4016104_-|glycogen-synthase
MTREYPPEVYGGAGVHVTELVAQLRQLCEVDVHCMGAPRDGAFVHQPDPALADANAAISTLSTDLVMANAAGAATVVHSHTWYAEMAGHLASLLYGIPHVVTAHSLEPMRPWKAEQLGGGYRISSWVEKTAMEAAAAVIAVSSGMRDDVLAVYPGLDPERVHVVKNGIDTAVWYPVEPGADSVLAELGVDPSRPIASFVGRITRQKGVKHLVAAAHRFDPEVQLVLCAGAPDTPEIAAETAGAVAELSASRPGVFWVQEMLPTAKIREILSASAVFVCPSVYEPLGIVNLEAMACGTAVVASAVGGIPEVVDDGVTGTLVRYTPEDAAAFEAGIADAVNALVNDPARAVRYGAAGRQRCIDEFSWARIAEQTLQIYRAVAG
>NZ_AP022603.1|WP_068532479.1|4014783_4014951_+|DUF3117-domain-containing-protein
MAAMKPRTGDGPLEATKEGRGIVMRVPLEGGGRLVVELTPDEAAALGEELRGVTS
>NZ_AP022603.1|WP_085092529.1|4014051_4014630_+|DNA-3-methyladenine-glycosylase-I
MSAAEPVRCGWVVGGPQIYLDYHDREWGRPLRGTRELFERIALESFQSGLSWLTILRKRDNFRAAFAGFDVEAVAGFGDDDVTRLLGDAGIVRNRAKIEATVANARAIAGLDTDLTELLWSFAPPARPRPAALSQVPAVTAESTAMAKELKRCGFRFVGPTTAYALMQATGMVDDHLRDCWVPVTPAAGPIE
>NZ_AP022603.1|WP_085092544.1|4013743_4014055_+|DivIVA-domain-containing-protein
MTLVLLYLVVLVLVAAVLFGLATVLFGRGEPLPPLPRGTTATTLPASGVSGADVDAVKFTQALRGYKTSEVDWVLERLATELDSLRGELDTLRALHDAQEPAQ
>NZ_AP022603.1|WP_085092530.1|4012731_4013685_+|glucosyl-3-phosphoglycerate-synthase
MTTTPAPDRFHLDDAAQRWMTTHSWNRPTWTVAELTEAKAAAGQTVSVVLPALDEEDTVGAVVDSIAPMLGGLVDELIVLDSGSTDDTGIRAVAAGARVISREQALPELAPQPGKGEVLWRSLAATTGDLIVFVDADLIDPDPMFVPRLLGPLLTGAGISLVKGYYRRPLKISGSEDASGGGRVTELVARPLLTALRPELGLLLQPLGGEYAGTRELLTALRFAPGYGVEIGLLIDAYDRLGLNAIAQVNLGVRAHRNRPLTELGAMSRQVIATLLSRCGVADSGIGLTQFFADGDSFTPRTTEVSLADRPPMNTLR
>NZ_AP022603.1|WP_085092531.1|4011859_4012735_+|dihydropteroate-synthase
MRATFLGKPVAGDRALIMAIVNRTPDSFFDRGATFTDEAAKQATHRAIEQGADVIDVGGVKAGPGQVVGPAEEIARVVPFIEWLRARYPEQLISVDTWRAEVATLACAAGADLINDTWAGADPGLPEVAAEFGAGLVCSHTGHAIPRTRPFRVNYGITETGVLDDVIAAVTGAAEKAVAAGVRRDAILIDPTHDFGKNTHHGLALLRGVKDLVNTGWPVLMALSNKDFVGETLGVDVTERLEGTLAATALAAADGARMFRVHQVDPTRRVLEMVASIRGLRAPARAVRGLA
>NZ_AP022603.1|WP_085092532.1|4010041_4011823_+|long-chain-acyl-CoA-synthetase
MSASDSRASVGVLDLVRQLPSLAADLPAIVRGVSTGILVTPTSKTSIGKVFEDRTRKYGDRVFLKFGDQQFSYAEANAAANRYASVLAERGVGHGDVVGLLLRNTPQTIFAMLGVVKCGAVAGMLNFHQRGDVLAHSIGLLNATVLISEADLVEHITECGVDLPDGVVVTVEEFDKLAEGRPVGNPASTQAVLAKDPAFYIFTSGTTGNPKASVMTHSRWLKALAGFGGLGLRMRGDDVLYSCLPLYHNNALTVGIASVLNSGSALALGEKFSATRFWDDVIRYRATAFLYIGELCRYLVNQPAKPTDRAHNVRLIAGNGLRPELWDEFTERFGIERVCEFYAASEGNAAFINVFNVDKSTGFSWFPLSYVEYDVETGDPVRDAAGRLRRVPAGEPGLLITPVNRLSPFDGYTDPAASEKKLIRNAFKDGDVWFNTGDVMRPQGMGHAAFGDRLGDTFRWKGENVATTEVEAALTADPQVEECTVFGVEVPNTGGRAGMAAIKLRGGESFDGIELSETLYAKLPNYAIPLFIRVVDSLEHTTTFKSRKVDLREEAYGPQVTDPLFVLGGRREGFVPFHDAYPGEVAAGVSPKP
>NZ_AP022603.1|WP_085092533.1|4009441_4009999_+|TIGR00730-family-Rossman-fold-protein
MSRPWAVCVYCASGPGDPELLALADAVGRAIAERGWSVISGGGSVSAMGALADGARARGGHTVGVIPKALLHREVADVHADELLVTDTMRQRKQIMEDRADAFLALPGGIGTLEELFEAWTAGFLGMHDKPVVILDPGGHYDGLMSWLQGLVGTGYVAQSAIDALPVVRDLELALQLCAPPPAAH
>NZ_AP022603.1|WP_085092534.1|4008371_4009445_+|succinyl-diaminopimelate-desuccinylase
MLDLHADPIDLTAALVDIRSESRDEKQLADAVEAALRAQTRGFEVIRNGDAVLARTNHGHRSRVLLAGHLDTVPIADNLPSRRDDEFLWGCGTSDMKAGDAVFLHLAATIAEPAHDLTLVFYDCEEIEASANGLGRIERELPDWLRADVAILGEPTGGYIEAGCQGTLRVVVAAAGTRAHSARSWMGDNAIHRLAPVLDRLAQYSAREVDIDGCVYREGLSAVRIDGGVAGNVIPDAAAVTVNFRFAPDRSPEQALAHVTEVFDGLDVTIELTDSAAGALPGLSQPAAAALVEAAGGAVRAKYGWTDVARFAALGIPAVNFGPGDPNLAHRRDERVELALITDGTAMLRSYLTGGPA
>NZ_AP022603.1|WP_085100042.1|4017745_4018420_-|isoprenylcysteine-carboxylmethyltransferase-family-protein
MTMTLRTIAYTLAGFALFAALLFWPAGTFDYWQGWAVIAVMIGLSLPYTVYLITRRPDVLARRIRSGPTAETRGVQKLAVGVLQLSFLAFLVVGGFDHRFGWSRVPTWLCIVGIVLLAVGLGIAIWVVVQNSWAAAIITIESGQQLVSTGMYAVVRHPMYSGAVLMCIGCPLALGSYWALLPAVPAVLSLVVRTVDEETLLRTDLPGYVDYTQRVRSRLLPGIW
>NZ_AP022603.1|WP_163742607.1|4018440_4020084_-|ABC-transporter-permease
MTTVARPRSPAPAPASASDFTGTAELLRLNLRRDRIIGPIWILLLSLPLGGVYIGSIEKVYPTAADRAGLIDTIMASPAQRAMYGNIYSESLGALGVWKAGVYGALIGIAVILTVIRHTRADEETGRTELLGSTAVGRLAGLTAALILGYGAVGITALIGFASLASTGIPAAGSAAFAAGLAGAGLVFGGVAAVTAQLSSSARTARSLAFSVLGAAYALRAVGDATSADGSSVLSWLSPLGWSLQVRAFAGDRFWVLGLHLLTATALTLLAYALLSRRDLGAGLLPERRGPATAGPALSGVFGLAWRVSRGSVLLWAAGLSLYGLMIGSAVHGIGDQLGDTAGTRDIVTRLGGSPAVEQAFIHLAFTMVAVLTSAFAISATLRLHQEESTGRAETVLAGAVPRTRWLAGYLALALTSSAVIMLAAGAFAGLTYAASAGDIGVLSTVIGSALVQLPGVWLLAAVTVLLIGWVPRAAPAAWAVLVGFVALFLLGSLAGFPRWLQNLDPYSHAPSVGTGAFTAWPLIWLLALDALLIAVGAAAFGRRDVG
>NZ_AP022603.1|WP_085100039.1|4020080_4020980_-|ABC-transporter-ATP-binding-protein
MNQPDIEIHGLTKRFGPTQALDGLDLRVGPGEVHGFLGPNGAGKSTTIRILLGLARADGGTVRLLGSDPWDDAVSLHRQIAYVPGDVTLWPGLTGGEIIDLLARMRGGIDERRRTELIERFDLDPTKRARSYSKGNRQKVSLVSAFASNARLLLLDEPSSGLDPLMENVFQQCVAEARDRGSTVLLSSHILAETEKLCDRLTLIRAGRTVETGTLASLRHLSRTSITAELLRDPGDLGRIRGVQDVRFEGQVLHAQVDADALDELIRALGQAGVRSLVSRPPTLEDLFLRHYGSEPVNA
>NZ_AP022603.1|WP_085100049.1|4020999_4021638_-|TetR-family-transcriptional-regulator
MRSTSDLSTADRIRDAAIDQFGRHGFGVGVRAIAAAAGVSPGLVNHHFGSKGGLRAACDTHVAEVVREAKSETLQTHDPAAWLTAAAEIEDYAPLTGYLVRSLQSGGELARTLWRRMIDNAEQYLEEGVRAGTIKPTADPRARARFLSMVGGGAFLLYIQLHDDPGDLRRVLHDYTQDMMLPALELYSNGLLTDPGLYQAFLARAEETGGIA
>NZ_AP022603.1|WP_085100036.1|4021711_4022464_-|O-methyltransferase
MASSEDTDLTFAPAASSPADPPAAEPADSPAPEPAAPSPAEAMLAHAEASISEDSVLAAVRERAQDIGAEAVTPAVGALLSLLARLSGGKAVVEVGTGAGLSGLWLLSGMRPDGVLTTIDIEPEYQRVARQAFTEGGIGPSRTRLITGRAQEVLTRLADTSYDLVFIDADPADQPDYVAEGIRLLRPGGVIVVHSAALGGRAGDPAAQDATVAAVREAARLIAEDERLVPVVIPLGDGVLAAAREYSDPE
>NZ_AP022603.1|WP_085100032.1|4022651_4023422_+|RNA-polymerase-sigma-factor-SigE
MDQREKRPPSRVDGRNTGVPVDVAENMQRVRVSNRDSVRTDQEDPTTIATIAPVSMSHPETDYGAEWVEVSDEPTGTAVFDATGDQTTMPSWDELVRQHADRVYRLAYRLSGNRQDAEDLTQDTFIRVFRSLQSYQPGTFEGWLHRITTNLFLDMVRRRARIRMEALPEDYDRVPATDPDPEQIYHDAHLQADLQAALDSLAPEFRAAVVLCDIEGLSYEEIATTLDVKLGTVRSRIHRGRQAIRDHLASRSVATS
>NZ_AP022603.1|WP_085100029.1|4023529_4023949_+|zf-HC2-domain-containing-protein
MTDRGPGFRRVFSWLPAQLGAGLVDDGVGTAPRRFGSTEHLSTEALAAFVDGELPVSAQLRATHHLALCPECSAEVGAQRQARAALRDSTPITAPSTLLGMLSRIPLAPPIPPDDLIPDPDPAPQPEDREGRFPWRRRR
>NZ_AP022603.1|WP_085100046.1|4024050_4025562_+|trypsin-like-peptidase-domain-containing-protein
MSSNQHNPGRGPAGPRLAPRPVSRPPVDEASRRTFGRPQGVEGSFLAKEVRSKRFREGDEFQPTDQPPDPVLAQAFGRPHAGGDSLQRHPVDAGALEAERDSEADEFADPWRDPEAAPSLGTPAVATSTVAAVPAPMGKLGVREVLFGGRVRYRALAVLAVIALAIGMVGGVVGRKTAEIVQAFTTSKVTLQTSDNPEGEAGRFAAVAASVADSVVTIEAESKTLGSQGSGVVIDGAGFVVTNNHVIADAAASPAEFTISVVFNDGKSVPANLVGRDPKSDLAVLKVDNVDNLVVGRLGDSDKLRVGEEVIAAGAPLGLRSTVTHGIISALHRPVSLPGDGGDTRTIIDAVQTDASINHGNSGGPLINMDSEVIGINTAGKSLSDSASGLGFAIPVNDVKQIAQELIRNGKAEHPDLGINTKSASKTMAQGAMVENVHAGSPGEAAGVVEHDVVVKLGGRSVADADEFAVAERDLVIGEPTQIEVIREGRPVTLEITPRSDLR
>NZ_AP022603.1|WP_085100025.1|4025571_4025973_+|Sec-independent-protein-translocase-subunit-TatB
MFANLGWGEVLVLLVIGLVVLGPERLPGAIRWTSGALRQARDYLNSATAQIREDIGPEFDDLREPLGEINKLRGMSPRAALTKHLLDGDDSFLTGDFGARPGSADADRDAPAAPSAPAPDAGPAQPRFDTDAT
>NZ_AP022603.1|WP_085100022.1|4026008_4027148_-|Mrp/NBP35-family-ATP-binding-protein
MSDSTRPEDELTAAVRAALAKVIDPELRRPITELGMVKSIQIGDDAAVVVEIYLTTAACPKKTEISTQVTEAVTDVPGTGAVKVVLDVMNDEQRTELRRQLRGDSPEPVIPFAQPGSLTRVYAVASGKGGVGKSSVTVNLAAALAARGLNVGLLDADIYGHSVPRMMGTTDRPAQVDSMIVPPVAHDVKIISIAQFTQGNTPVVWRGPMLHRALQQFLADVYWGDLDVLLLDLPPGTGDVAISIAQLIPNAEIIVVTTPQLAAAEVAERAGAIAVQTRQRIAGVVENMVDSPTLKMFGEGGGRQVAESLTRIMGVDVPVLGQVPLDPALVTAGDDGVPLVLSAPDTGAGAELNKVADQLASKKRGLAGMSLGLDTTRHG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_AP022603_5	5.1\|664535\|18\|NZ_AP022603\|CRT	664535-664552	18	NZ_AP022603.1	682665-682682	0	1.0
NZ_AP022603_5	5.3\|664635\|18\|NZ_AP022603\|CRT	664635-664652	18	NZ_AP022603.1	682665-682682	0	1.0
NZ_AP022603_5	5.1\|664535\|18\|NZ_AP022603\|CRT	664535-664552	18	NZ_AP022603.1	2923885-2923902	1	0.944
NZ_AP022603_5	5.3\|664635\|18\|NZ_AP022603\|CRT	664635-664652	18	NZ_AP022603.1	2923885-2923902	1	0.944
NZ_AP022603_5	5.4\|664685\|18\|NZ_AP022603\|CRT	664685-664702	18	NZ_AP022603.1	602451-602468	1	0.944
NZ_AP022603_5	5.4\|664685\|18\|NZ_AP022603\|CRT	664685-664702	18	NZ_AP022603.1	2923834-2923851	1	0.944
NZ_AP022603_5	5.4\|664685\|18\|NZ_AP022603\|CRT	664685-664702	18	NZ_AP022603.1	2963035-2963052	1	0.944

1. spacer 5.1|664535|18|NZ_AP022603|CRT matches to position: 682665-682682, mismatch: 0, identity: 1.0

acttttgccggccgcgct	CRISPR spacer
acttttgccggccgcgct	Protospacer
******************

2. spacer 5.3|664635|18|NZ_AP022603|CRT matches to position: 682665-682682, mismatch: 0, identity: 1.0

acttttgccggccgcgct	CRISPR spacer
acttttgccggccgcgct	Protospacer
******************

3. spacer 5.1|664535|18|NZ_AP022603|CRT matches to position: 2923885-2923902, mismatch: 1, identity: 0.944

acttttgccggccgcgct	CRISPR spacer
actgttgccggccgcgct	Protospacer
*** **************

4. spacer 5.3|664635|18|NZ_AP022603|CRT matches to position: 2923885-2923902, mismatch: 1, identity: 0.944

acttttgccggccgcgct	CRISPR spacer
actgttgccggccgcgct	Protospacer
*** **************

5. spacer 5.4|664685|18|NZ_AP022603|CRT matches to position: 602451-602468, mismatch: 1, identity: 0.944

cgttttgccggggcccga	CRISPR spacer
cgttttggcggggcccga	Protospacer
******* **********

6. spacer 5.4|664685|18|NZ_AP022603|CRT matches to position: 2923834-2923851, mismatch: 1, identity: 0.944

cgttttgccggggcccga	CRISPR spacer
cgttttggcggggcccga	Protospacer
******* **********

7. spacer 5.4|664685|18|NZ_AP022603|CRT matches to position: 2963035-2963052, mismatch: 1, identity: 0.944

cgttttgccggggcccga	CRISPR spacer
cgttttggcggggcccga	Protospacer
******* **********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP022603_19	19.1\|3995665\|22\|NZ_AP022603\|CRISPRCasFinder	3995665-3995686	22	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	1494718-1494739	2	0.909
NZ_AP022603_2	2.1\|268139\|25\|NZ_AP022603\|CRISPRCasFinder	268139-268163	25	NZ_CP054028	Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence	1268274-1268298	3	0.88
NZ_AP022603_15	15.1\|3783032\|25\|NZ_AP022603\|CRISPRCasFinder	3783032-3783056	25	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	1837848-1837872	3	0.88
NZ_AP022603_15	15.1\|3783032\|25\|NZ_AP022603\|CRISPRCasFinder	3783032-3783056	25	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	1789462-1789486	3	0.88
NZ_AP022603_2	2.1\|268139\|25\|NZ_AP022603\|CRISPRCasFinder	268139-268163	25	NC_009427	Novosphingobium aromaticivorans DSM 12444 plasmid pNL2, complete sequence	340825-340849	4	0.84
NZ_AP022603_3	3.1\|441254\|27\|NZ_AP022603\|CRISPRCasFinder	441254-441280	27	NZ_AP022335	Methylosinus sp. C49 isolate Methylosinus sp. C49 plasmid pMSC49c, complete sequence	103908-103934	4	0.852
NZ_AP022603_15	15.1\|3783032\|25\|NZ_AP022603\|CRISPRCasFinder	3783032-3783056	25	NZ_CP026526	Sinorhizobium meliloti strain AK21 plasmid pSymA, complete sequence	102653-102677	4	0.84
NZ_AP022603_3	3.1\|441254\|27\|NZ_AP022603\|CRISPRCasFinder	441254-441280	27	CP006880	Rhizobium gallicum bv. gallicum R602 plasmid pRgalR602c, complete sequence	24241-24267	5	0.815
NZ_AP022603_11	11.1\|2535923\|29\|NZ_AP022603\|CRISPRCasFinder	2535923-2535951	29	NZ_CP012944	Ralstonia solanacearum strain IBSBF1503 plasmid unnamed, complete sequence	1037359-1037387	5	0.828
NZ_AP022603_11	11.1\|2535923\|29\|NZ_AP022603\|CRISPRCasFinder	2535923-2535951	29	NZ_CP029356	Azospirillum sp. CFH 70021 plasmid unnamed1	406864-406892	5	0.828
NZ_AP022603_11	11.1\|2535923\|29\|NZ_AP022603\|CRISPRCasFinder	2535923-2535951	29	NZ_CP012940	Ralstonia solanacearum strain UW163 plasmid unnamed, complete sequence	857071-857099	5	0.828
NZ_AP022603_11	11.1\|2535923\|29\|NZ_AP022603\|CRISPRCasFinder	2535923-2535951	29	NC_017575	Ralstonia solanacearum Po82 megaplasmid, complete sequence	1360478-1360506	5	0.828
NZ_AP022603_11	11.1\|2535923\|29\|NZ_AP022603\|CRISPRCasFinder	2535923-2535951	29	NZ_CP026308	Ralstonia solanacearum strain IBSBF 2571 plasmid unnamed, complete sequence	1360422-1360450	5	0.828
NZ_AP022603_11	11.1\|2535923\|29\|NZ_AP022603\|CRISPRCasFinder	2535923-2535951	29	NZ_CP051295	Ralstonia solanacearum strain CIAT_078 plasmid megaplasmid, complete sequence	848810-848838	5	0.828
NZ_AP022603_1	1.2\|235673\|33\|NZ_AP022603\|CRT	235673-235705	33	NZ_CP023740	Methylosinus trichosporium OB3b plasmid pOB3b3, complete sequence	4099-4131	7	0.788
NZ_AP022603_3	3.1\|441254\|27\|NZ_AP022603\|CRISPRCasFinder	441254-441280	27	NZ_CP037902	Cupriavidus metallidurans strain BS1 plasmid p1, complete sequence	298994-299020	7	0.741
NZ_AP022603_3	3.1\|441254\|27\|NZ_AP022603\|CRISPRCasFinder	441254-441280	27	NZ_CP029174	Methylobacterium sp. DM1 plasmid pLVM1, complete sequence	141354-141380	7	0.741
NZ_AP022603_11	11.1\|2535923\|29\|NZ_AP022603\|CRISPRCasFinder	2535923-2535951	29	HM461982	Burkholderia phage KS14, complete genome	21781-21809	7	0.759
NZ_AP022603_11	11.1\|2535923\|29\|NZ_AP022603\|CRISPRCasFinder	2535923-2535951	29	MH588544	Caulobacter phage CcrBL10, complete genome	31544-31572	7	0.759
NZ_AP022603_13	13.1\|3143911\|29\|NZ_AP022603\|CRISPRCasFinder	3143911-3143939	29	NZ_CP032322	Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence	754722-754750	7	0.759
NZ_AP022603_13	13.1\|3143911\|29\|NZ_AP022603\|CRISPRCasFinder	3143911-3143939	29	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	399106-399134	7	0.759
NZ_AP022603_13	13.1\|3143911\|29\|NZ_AP022603\|CRISPRCasFinder	3143911-3143939	29	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	1588531-1588559	7	0.759
NZ_AP022603_13	13.1\|3143911\|29\|NZ_AP022603\|CRISPRCasFinder	3143911-3143939	29	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	739122-739150	7	0.759
NZ_AP022603_13	13.1\|3143911\|29\|NZ_AP022603\|CRISPRCasFinder	3143911-3143939	29	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	1118331-1118359	7	0.759
NZ_AP022603_13	13.1\|3143911\|29\|NZ_AP022603\|CRISPRCasFinder	3143911-3143939	29	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	1014047-1014075	7	0.759
NZ_AP022603_13	13.1\|3143911\|29\|NZ_AP022603\|CRISPRCasFinder	3143911-3143939	29	JX878496	Serratia phage phiMAM1, complete genome	29856-29884	7	0.759
NZ_AP022603_13	13.1\|3143911\|29\|NZ_AP022603\|CRISPRCasFinder	3143911-3143939	29	MF285619	Serratia phage 2050H1, complete genome	31068-31096	7	0.759
NZ_AP022603_11	11.1\|2535923\|29\|NZ_AP022603\|CRISPRCasFinder	2535923-2535951	29	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	855917-855945	8	0.724
NZ_AP022603_11	11.1\|2535923\|29\|NZ_AP022603\|CRISPRCasFinder	2535923-2535951	29	NZ_CP048426	Rhizobium daejeonense strain KACC 13094 plasmid unnamed3, complete sequence	153509-153537	8	0.724
NZ_AP022603_11	11.1\|2535923\|29\|NZ_AP022603\|CRISPRCasFinder	2535923-2535951	29	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	1276465-1276493	8	0.724
NZ_AP022603_1	1.2\|235673\|33\|NZ_AP022603\|CRT	235673-235705	33	NC_022044	Paracoccus aminophilus JCM 7686 plasmid pAMI6, complete sequence	190697-190729	9	0.727
NZ_AP022603_11	11.1\|2535923\|29\|NZ_AP022603\|CRISPRCasFinder	2535923-2535951	29	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	1764299-1764327	9	0.69
NZ_AP022603_11	11.1\|2535923\|29\|NZ_AP022603\|CRISPRCasFinder	2535923-2535951	29	NZ_CP046573	Rhodococcus sp. WAY2 plasmid pRWAY01, complete sequence	392634-392662	9	0.69
NZ_AP022603_1	1.2\|235673\|33\|NZ_AP022603\|CRT	235673-235705	33	NZ_CP022417	Sulfitobacter pseudonitzschiae strain SMR1 plasmid pSMR1-2, complete sequence	280725-280757	10	0.697
NZ_AP022603_1	1.2\|235673\|33\|NZ_AP022603\|CRT	235673-235705	33	NZ_CP034352	Streptomyces sp. W1SF4 plasmid p2, complete sequence	179530-179562	10	0.697
NZ_AP022603_14	14.1\|3391920\|35\|NZ_AP022603\|CRISPRCasFinder	3391920-3391954	35	NC_013531	Xylanimonas cellulosilytica DSM 15894 plasmid pXCEL01, complete sequence	88286-88320	11	0.686
NZ_AP022603_1	1.1\|235604\|51\|NZ_AP022603\|CRT	235604-235654	51	NZ_CP029602	Streptomyces sp. WAC 01438 plasmid unnamed1, complete sequence	3808-3858	12	0.765
NZ_AP022603_1	1.1\|235604\|51\|NZ_AP022603\|CRT	235604-235654	51	NZ_CP029602	Streptomyces sp. WAC 01438 plasmid unnamed1, complete sequence	50277-50327	12	0.765
NZ_AP022603_1	1.1\|235604\|51\|NZ_AP022603\|CRT	235604-235654	51	NC_006912	Streptomyces sp. FQ1 plasmid pFP1, complete sequence	28193-28243	12	0.765

1. spacer 19.1|3995665|22|NZ_AP022603|CRISPRCasFinder matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 2, identity: 0.909

ggcgagccgggagcggcgtcct	CRISPR spacer
ggcgagacgggagcggcgtccg	Protospacer
****** **************

2. spacer 2.1|268139|25|NZ_AP022603|CRISPRCasFinder matches to NZ_CP054028 (Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence) position: , mismatch: 3, identity: 0.88

aggcccatgcggtgcgcatgtcact	CRISPR spacer
aggccaatgcggtgcgcatgtcaaa	Protospacer
***** *****************

3. spacer 15.1|3783032|25|NZ_AP022603|CRISPRCasFinder matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 3, identity: 0.88

gttggtgcggccggtctcttcctcg	CRISPR spacer
gatggtgcgggcggtctcttcctcc	Protospacer
* ******** *************

4. spacer 15.1|3783032|25|NZ_AP022603|CRISPRCasFinder matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 3, identity: 0.88

gttggtgcggccggtctcttcctcg	CRISPR spacer
gatggtgcgggcggtctcttcctcc	Protospacer
* ******** *************

5. spacer 2.1|268139|25|NZ_AP022603|CRISPRCasFinder matches to NC_009427 (Novosphingobium aromaticivorans DSM 12444 plasmid pNL2, complete sequence) position: , mismatch: 4, identity: 0.84

aggcccatgcggtgcgcatgtcact	CRISPR spacer
gggcccatgcggtgctcatgtcgcg	Protospacer
.************** ******.*

6. spacer 3.1|441254|27|NZ_AP022603|CRISPRCasFinder matches to NZ_AP022335 (Methylosinus sp. C49 isolate Methylosinus sp. C49 plasmid pMSC49c, complete sequence) position: , mismatch: 4, identity: 0.852

cctgaggcgcggggcgactcgctccgg	CRISPR spacer
cttgagccgcggcgcgactcgctccag	Protospacer
*.**** ***** ************.*

7. spacer 15.1|3783032|25|NZ_AP022603|CRISPRCasFinder matches to NZ_CP026526 (Sinorhizobium meliloti strain AK21 plasmid pSymA, complete sequence) position: , mismatch: 4, identity: 0.84

gttggtgcggccggtctcttcctcg	CRISPR spacer
gttgatgcggccggtcacttcctga	Protospacer
****.*********** ****** .

8. spacer 3.1|441254|27|NZ_AP022603|CRISPRCasFinder matches to CP006880 (Rhizobium gallicum bv. gallicum R602 plasmid pRgalR602c, complete sequence) position: , mismatch: 5, identity: 0.815

cctgaggcgcggggcgactcgctccgg	CRISPR spacer
gctgaggcgcgggccgtctcgctctcg	Protospacer
 ************ ** *******. *

9. spacer 11.1|2535923|29|NZ_AP022603|CRISPRCasFinder matches to NZ_CP012944 (Ralstonia solanacearum strain IBSBF1503 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.828

accggccggcaacaacgccggccggttct	CRISPR spacer
accggccggcaacaacggcggcggtccct	Protospacer
***************** **** * ..**

10. spacer 11.1|2535923|29|NZ_AP022603|CRISPRCasFinder matches to NZ_CP029356 (Azospirillum sp. CFH 70021 plasmid unnamed1) position: , mismatch: 5, identity: 0.828

accggccggcaacaacgccggccggttct	CRISPR spacer
ccagtccggcaacaacgccggcccgctct	Protospacer
 * * ****************** *.***

11. spacer 11.1|2535923|29|NZ_AP022603|CRISPRCasFinder matches to NZ_CP012940 (Ralstonia solanacearum strain UW163 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.828

accggccggcaacaacgccggccggttct	CRISPR spacer
accggccggcaacaacggcggcggtccct	Protospacer
***************** **** * ..**

12. spacer 11.1|2535923|29|NZ_AP022603|CRISPRCasFinder matches to NC_017575 (Ralstonia solanacearum Po82 megaplasmid, complete sequence) position: , mismatch: 5, identity: 0.828

accggccggcaacaacgccggccggttct	CRISPR spacer
accggccggcaacaacggcggcggtccct	Protospacer
***************** **** * ..**

13. spacer 11.1|2535923|29|NZ_AP022603|CRISPRCasFinder matches to NZ_CP026308 (Ralstonia solanacearum strain IBSBF 2571 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.828

accggccggcaacaacgccggccggttct	CRISPR spacer
accggccggcaacaacggcggcggtccct	Protospacer
***************** **** * ..**

14. spacer 11.1|2535923|29|NZ_AP022603|CRISPRCasFinder matches to NZ_CP051295 (Ralstonia solanacearum strain CIAT_078 plasmid megaplasmid, complete sequence) position: , mismatch: 5, identity: 0.828

accggccggcaacaacgccggccggttct	CRISPR spacer
accggccggcaacaacggcggcggtccct	Protospacer
***************** **** * ..**

15. spacer 1.2|235673|33|NZ_AP022603|CRT matches to NZ_CP023740 (Methylosinus trichosporium OB3b plasmid pOB3b3, complete sequence) position: , mismatch: 7, identity: 0.788

accggcca-aggccgccaccaagtcggtggcgaa	CRISPR spacer
-ccggtagcgggccgccacctcgtcggtggcgaa	Protospacer
 ****. . .**********  ************

16. spacer 3.1|441254|27|NZ_AP022603|CRISPRCasFinder matches to NZ_CP037902 (Cupriavidus metallidurans strain BS1 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.741

cctgaggcgcggggcgactcgctccgg	CRISPR spacer
ggcgaggcgctgggcgactcgctctac	Protospacer
  .******* *************..

17. spacer 3.1|441254|27|NZ_AP022603|CRISPRCasFinder matches to NZ_CP029174 (Methylobacterium sp. DM1 plasmid pLVM1, complete sequence) position: , mismatch: 7, identity: 0.741

cctgaggcgcggggcgactcgctccgg	CRISPR spacer
ggcgaggcgctgggcgactcgctctac	Protospacer
  .******* *************..

18. spacer 11.1|2535923|29|NZ_AP022603|CRISPRCasFinder matches to HM461982 (Burkholderia phage KS14, complete genome) position: , mismatch: 7, identity: 0.759

accggccggcaacaacgccggccggttct	CRISPR spacer
tgcggccggcaccaacgccggccgcacgt	Protospacer
  ********* ************  . *

19. spacer 11.1|2535923|29|NZ_AP022603|CRISPRCasFinder matches to MH588544 (Caulobacter phage CcrBL10, complete genome) position: , mismatch: 7, identity: 0.759

accggccggcaacaacgccggccggttct	CRISPR spacer
cccggccggcaacaccgccggcggcgacg	Protospacer
 ************* ******* *   *

20. spacer 13.1|3143911|29|NZ_AP022603|CRISPRCasFinder matches to NZ_CP032322 (Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.759

gcggggtggttcggccagcgcgcacttct	CRISPR spacer
gcggagtggttcggccagcgcgagcagtc	Protospacer
****.***************** .*  ..

21. spacer 13.1|3143911|29|NZ_AP022603|CRISPRCasFinder matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 7, identity: 0.759

gcggggtggttcggccagcgcgcacttct	CRISPR spacer
gcggagtggttcggccagcgcgagcagtc	Protospacer
****.***************** .*  ..

22. spacer 13.1|3143911|29|NZ_AP022603|CRISPRCasFinder matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 7, identity: 0.759

gcggggtggttcggccagcgcgcacttct	CRISPR spacer
gcggagtggttcggccagcgcgagcagtc	Protospacer
****.***************** .*  ..

23. spacer 13.1|3143911|29|NZ_AP022603|CRISPRCasFinder matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.759

gcggggtggttcggccagcgcgcacttct	CRISPR spacer
gcggagtggttcggccagcgcgagcagtc	Protospacer
****.***************** .*  ..

24. spacer 13.1|3143911|29|NZ_AP022603|CRISPRCasFinder matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 7, identity: 0.759

gcggggtggttcggccagcgcgcacttct	CRISPR spacer
gcggagtggttcggccagcgcgagcagtc	Protospacer
****.***************** .*  ..

25. spacer 13.1|3143911|29|NZ_AP022603|CRISPRCasFinder matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.759

gcggggtggttcggccagcgcgcacttct	CRISPR spacer
gcggagtggttcggccagcgcgagcagtc	Protospacer
****.***************** .*  ..

26. spacer 13.1|3143911|29|NZ_AP022603|CRISPRCasFinder matches to JX878496 (Serratia phage phiMAM1, complete genome) position: , mismatch: 7, identity: 0.759

gcggggtggttcggccagcgcgcacttct	CRISPR spacer
tcaggatggttcggccagcgcgcgctgtg	Protospacer
 *.**.*****************.** .

27. spacer 13.1|3143911|29|NZ_AP022603|CRISPRCasFinder matches to MF285619 (Serratia phage 2050H1, complete genome) position: , mismatch: 7, identity: 0.759

gcggggtggttcggccagcgcgcacttct	CRISPR spacer
tcaggatggttcggccagcgcgcgctgtg	Protospacer
 *.**.*****************.** .

28. spacer 11.1|2535923|29|NZ_AP022603|CRISPRCasFinder matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.724

accggccggcaacaacgccggccggttct	CRISPR spacer
cctggacggcaacaacgccggccgcaagg	Protospacer
 *.** ******************

29. spacer 11.1|2535923|29|NZ_AP022603|CRISPRCasFinder matches to NZ_CP048426 (Rhizobium daejeonense strain KACC 13094 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.724

accggccggcaacaacgccggccggttct	CRISPR spacer
agcggccggcaacaatgccggccccgatc	Protospacer
* *************.*******    ..

30. spacer 11.1|2535923|29|NZ_AP022603|CRISPRCasFinder matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 8, identity: 0.724

accggccggcaacaacgccggccggttct	CRISPR spacer
cctggacggcaacaacgccggccgcaagg	Protospacer
 *.** ******************

31. spacer 1.2|235673|33|NZ_AP022603|CRT matches to NC_022044 (Paracoccus aminophilus JCM 7686 plasmid pAMI6, complete sequence) position: , mismatch: 9, identity: 0.727

accggccaaggccgccaccaagtcggtggcgaa	CRISPR spacer
ttcggccaaggccgccatcaggtcgggatcgtt	Protospacer
 .***************.**.***** . **

32. spacer 11.1|2535923|29|NZ_AP022603|CRISPRCasFinder matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 9, identity: 0.69

accggccggcaacaacgccggccggttct	CRISPR spacer
cgtggacggcaacaacgccggccgcaagg	Protospacer
  .** ******************

33. spacer 11.1|2535923|29|NZ_AP022603|CRISPRCasFinder matches to NZ_CP046573 (Rhodococcus sp. WAY2 plasmid pRWAY01, complete sequence) position: , mismatch: 9, identity: 0.69

accggccggcaacaacgccggccggttct	CRISPR spacer
ctatgccggcaagaacgccggccggcgtc	Protospacer
 .  ******** ************. ..

34. spacer 1.2|235673|33|NZ_AP022603|CRT matches to NZ_CP022417 (Sulfitobacter pseudonitzschiae strain SMR1 plasmid pSMR1-2, complete sequence) position: , mismatch: 10, identity: 0.697

accggccaaggccgccaccaagtcggtggcgaa	CRISPR spacer
cattgccaaggccgacaccaaggcggtgcttga	Protospacer
  . ********** ******* ***** . .*

35. spacer 1.2|235673|33|NZ_AP022603|CRT matches to NZ_CP034352 (Streptomyces sp. W1SF4 plasmid p2, complete sequence) position: , mismatch: 10, identity: 0.697

accggccaaggccgccaccaagtcggtggcgaa	CRISPR spacer
gggcatcccggccgccaccatgtcggcggcgaa	Protospacer
.   ..*  *********** *****.******

36. spacer 14.1|3391920|35|NZ_AP022603|CRISPRCasFinder matches to NC_013531 (Xylanimonas cellulosilytica DSM 15894 plasmid pXCEL01, complete sequence) position: , mismatch: 11, identity: 0.686

aggcaggccgaggaggcgctcggcggtgtttatcg	CRISPR spacer
aggcagtacgaggaggcgctcggcgacagcgacaa	Protospacer
******  *****************... . *. .

37. spacer 1.1|235604|51|NZ_AP022603|CRT matches to NZ_CP029602 (Streptomyces sp. WAC 01438 plasmid unnamed1, complete sequence) position: , mismatch: 12, identity: 0.765

caagaagacggcggccaagaagaccgccgccaagaagaccgccgccaagaa	CRISPR spacer
ccgcaaggcggcggccaagaagaccgccgcgaagaagaccgcgcccgcccc	Protospacer
* . ***.********************** ***********  **.

38. spacer 1.1|235604|51|NZ_AP022603|CRT matches to NZ_CP029602 (Streptomyces sp. WAC 01438 plasmid unnamed1, complete sequence) position: , mismatch: 12, identity: 0.765

caagaagacggcggccaagaagaccgccgccaagaagaccgccgccaagaa	CRISPR spacer
ccgcaaggcggcggccaagaagaccgccgcgaagaagaccgcgcccgcccc	Protospacer
* . ***.********************** ***********  **.

39. spacer 1.1|235604|51|NZ_AP022603|CRT matches to NC_006912 (Streptomyces sp. FQ1 plasmid pFP1, complete sequence) position: , mismatch: 12, identity: 0.765

caagaagacggcggccaagaagaccgccgccaagaagaccgccgccaagaa	CRISPR spacer
ccgcaaggcggcggccaagaagaccgccgcgaagaagaccgcgcccgcccc	Protospacer
* . ***.********************** ***********  **.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

939547 : 965349

Mycobacterium_phage(66.67%)

transposase,integrase

attL 935111:935127|attR 970960:970976

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
935111:935127	attL	NA	NA	NA	NA
WP_085100861.1\|939547_940867_-\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	1.3e-231	92.0
WP_085095809.1\|941288_941522_+	hypothetical protein	NA	NA	NA	NA
WP_085095811.1\|941518_941854_+	type II toxin-antitoxin system PemK/MazF family toxin	NA	NA	NA	NA
WP_133055135.1\|942299_942638_-	hypothetical protein	NA	NA	NA	NA
WP_085095815.1\|942808_944044_-\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	2.4e-110	53.2
WP_163742128.1\|944189_944675_-	hypothetical protein	NA	NA	NA	NA
WP_085095819.1\|944845_945910_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_163742211.1\|946172_946970_+\|transposase	TnsA-like heteromeric transposase endonuclease subunit	NA	NA	NA	NA
WP_163742215.1\|946966_947956_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_163742218.1\|949248_950286_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_085100120.1\|950293_951325_+	ATP-binding protein	NA	NA	NA	NA
WP_133055194.1\|951332_951650_+	hypothetical protein	NA	NA	NA	NA
WP_046253719.1\|954699_955728_+	TniB family NTP-binding protein	NA	NA	NA	NA
WP_046253720.1\|955729_956551_+	TniQ family protein	NA	NA	NA	NA
WP_163742221.1\|956988_958467_+	GMC family oxidoreductase N-terminal domain-containing protein	NA	NA	NA	NA
WP_046253722.1\|958518_959190_+	carboxymuconolactone decarboxylase family protein	NA	NA	NA	NA
WP_163742225.1\|959291_959717_+	hypothetical protein	NA	NA	NA	NA
WP_052740224.1\|959816_960389_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_046253724.1\|960398_961049_+	carboxymuconolactone decarboxylase family protein	NA	NA	NA	NA
WP_085100058.1\|961367_962126_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_083033565.1\|964035_965349_+\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	3.2e-230	91.8
970960:970976	attR	NA	NA	NA	NA

DBSCAN-SWA_2

1037389 : 1051728

Burkholderia_virus(50.0%)

transposase,integrase

attL 1038468:1038485|attR 1041385:1041402

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_085100076.1\|1037389_1038451_+\|transposase	IS110 family transposase	NA	NA	NA	NA
1038468:1038485	attL	NA	NA	NA	NA
WP_163742229.1\|1038958_1039264_+\|transposase	IS3 family transposase	A0A1B3AZE5	Gordonia_phage	3.1e-11	53.9
WP_085101219.1\|1039580_1040795_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_163742232.1\|1040861_1041380_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	Q8W6R2	Burkholderia_virus	1.3e-30	49.0
WP_085097531.1\|1041438_1041675_-	ubiD family decarboxylase	NA	NA	NA	NA
1041385:1041402	attR	NA	NA	NA	NA
WP_133055157.1\|1041838_1042717_+	hypothetical protein	NA	NA	NA	NA
WP_133055156.1\|1042716_1043229_+	hypothetical protein	NA	NA	NA	NA
WP_133055155.1\|1043234_1043666_-	hypothetical protein	NA	NA	NA	NA
WP_133055154.1\|1043689_1044433_-	hypothetical protein	NA	NA	NA	NA
WP_085097519.1\|1044469_1045411_-	DUF2185 domain-containing protein	NA	NA	NA	NA
WP_085097537.1\|1045626_1045890_-	hypothetical protein	NA	NA	NA	NA
WP_133055153.1\|1046639_1048475_-	hypothetical protein	NA	NA	NA	NA
WP_085097510.1\|1048893_1050129_-\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	2.9e-108	53.2
WP_109750552.1\|1050503_1051728_+\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	2.7e-58	46.3

DBSCAN-SWA_3

1712553 : 1721404

Mycobacterium_phage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_165757673.1\|1712553_1712898_+	CBS domain-containing protein	A0A2I6B2H4	Macacine_betaherpesvirus	2.3e-10	45.5
WP_085096943.1\|1712944_1713145_+	hypothetical protein	NA	NA	NA	NA
WP_109750538.1\|1713270_1713612_+	low affinity iron permease family protein	G1JW61	Mycobacterium_phage	1.2e-24	55.9
WP_085096938.1\|1713730_1713982_-	hypothetical protein	NA	NA	NA	NA
WP_085096935.1\|1713998_1714604_-	NAD(P)H-dependent oxidoreductase	NA	NA	NA	NA
WP_085096933.1\|1714732_1716901_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	V9VI16	Lactococcus_phage	8.5e-204	50.5
WP_085096930.1\|1716867_1717314_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	G3MBF1	Bacillus_virus	1.6e-08	31.7
WP_085096926.1\|1717389_1717641_-	glutaredoxin-like protein NrdH	V5UN81	Mycobacterium_phage	3.0e-20	63.6
WP_085096923.1\|1718067_1718640_-	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	9.6e-06	31.3
WP_085097188.1\|1718744_1719305_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_085096920.1\|1719342_1720533_+	AAA family ATPase	A0A077SLJ9	Escherichia_phage	2.2e-57	36.5
WP_085097185.1\|1720555_1721404_-	SDR family oxidoreductase	W8CYX9	Bacillus_phage	1.5e-07	30.3

DBSCAN-SWA_4

3190221 : 3238957

Burkholderia_phage(28.57%)

transposase,integrase

attL 3217626:3217641|attR 3242573:3242588

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_085100992.1\|3190221_3191484_+\|transposase	ISL3 family transposase	A9YX10	Burkholderia_phage	1.2e-29	28.3
WP_011895440.1\|3192613_3194350_-	DUF1446 domain-containing protein	NA	NA	NA	NA
WP_011895439.1\|3194346_3195159_-	TIGR03084 family protein	NA	NA	NA	NA
WP_011895438.1\|3195161_3195929_-	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
WP_163742513.1\|3196343_3196847_-\|transposase	transposase	A9YX10	Burkholderia_phage	1.9e-05	27.4
WP_163742515.1\|3196914_3197364_-\|transposase	transposase	NA	NA	NA	NA
WP_085095082.1\|3197710_3199219_-	carboxylesterase/lipase family protein	A0A0M4JT58	Mollivirus	7.8e-23	31.2
WP_085095108.1\|3199440_3200409_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_079626716.1\|3200576_3200897_+	2Fe-2S iron-sulfur cluster binding domain-containing protein	NA	NA	NA	NA
WP_085095080.1\|3200922_3202311_+	cytochrome P450	NA	NA	NA	NA
WP_085095078.1\|3202307_3203513_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_067992196.1\|3203778_3204189_+	SCP2 sterol-binding domain-containing protein	NA	NA	NA	NA
WP_078290122.1\|3204237_3205854_+	fatty acid--CoA ligase	NA	NA	NA	NA
WP_083000311.1\|3205899_3207006_+	NDMA-dependent alcohol dehydrogenase	E3SJ82	Synechococcus_phage	1.6e-36	29.9
WP_043985049.1\|3207277_3208378_+	BtrH N-terminal domain-containing protein	NA	NA	NA	NA
WP_043985051.1\|3208374_3209043_+	transglutaminase domain-containing protein	NA	NA	NA	NA
WP_162291742.1\|3209267_3209501_-	hypothetical protein	NA	NA	NA	NA
WP_078281697.1\|3209468_3209852_+	PaaI family thioesterase	NA	NA	NA	NA
WP_062655119.1\|3210033_3211083_+	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_043985058.1\|3212294_3213092_+	hypothetical protein	NA	NA	NA	NA
WP_163742521.1\|3213400_3214195_-	hypothetical protein	NA	NA	NA	NA
WP_043985060.1\|3214278_3215031_-	hypothetical protein	NA	NA	NA	NA
WP_082067868.1\|3215027_3215888_-	TIGR04255 family protein	NA	NA	NA	NA
WP_085095074.1\|3216081_3216540_-	hypothetical protein	NA	NA	NA	NA
3217626:3217641	attL	NA	NA	NA	NA
WP_043985064.1\|3218336_3218534_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_109749372.1\|3218548_3219871_+\|integrase	site-specific integrase	A0A0E3XBN7	Gordonia_phage	4.3e-57	39.5
WP_085095106.1\|3220111_3221326_-\|integrase	site-specific integrase	A0A1W6JQG4	Corynebacterium_phage	3.9e-49	36.6
WP_133055125.1\|3221318_3221843_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_085095070.1\|3221954_3222200_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_133055124.1\|3222379_3222679_+	hypothetical protein	NA	NA	NA	NA
WP_133055123.1\|3223006_3223753_-	hypothetical protein	NA	NA	NA	NA
WP_133055122.1\|3223755_3225951_-	cell division protein FtsK	NA	NA	NA	NA
WP_085095065.1\|3225953_3226430_-	hypothetical protein	NA	NA	NA	NA
WP_133055121.1\|3226432_3227134_-	hypothetical protein	NA	NA	NA	NA
WP_133055120.1\|3227133_3227451_-	hypothetical protein	NA	NA	NA	NA
WP_085095061.1\|3228067_3229024_-	DUF2637 domain-containing protein	NA	NA	NA	NA
WP_133055119.1\|3229062_3229998_-	hypothetical protein	NA	NA	NA	NA
WP_133055118.1\|3230032_3230416_-	hypothetical protein	NA	NA	NA	NA
WP_133055117.1\|3230453_3231902_-	hypothetical protein	NA	NA	NA	NA
WP_133055116.1\|3233685_3233982_+	hypothetical protein	NA	NA	NA	NA
WP_109750472.1\|3233981_3235298_+	hypothetical protein	NA	NA	NA	NA
WP_133055115.1\|3235495_3236029_+	hypothetical protein	NA	NA	NA	NA
WP_085095047.1\|3236201_3236621_-	hypothetical protein	NA	NA	NA	NA
WP_085095044.1\|3236832_3237192_-	hypothetical protein	NA	NA	NA	NA
WP_163742525.1\|3237181_3237445_-	hypothetical protein	NA	NA	NA	NA
WP_085095040.1\|3237820_3238957_-\|integrase	tyrosine-type recombinase/integrase	A0A0E3XBN7	Gordonia_phage	8.7e-51	35.8
3242573:3242588	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_AP022603

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection