CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_AP022566	Mycolicibacterium alvei strain JCM 12272 plasmid pJCM12272, complete sequence	0 crisprs	NA	0	0	25	0
NZ_AP022565	Mycolicibacterium alvei strain JCM 12272	5 crisprs	csa3,DEDDh,WYL,c2c9_V-U4,cas3,DinG	0	1	3	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 18832

Virus_Rctr197k(100.0%)

transposase,integrase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_088305589.1\|2628_2922_-	hypothetical protein	NA	NA	NA	NA
WP_088305588.1\|3640_4669_+	AraC family transcriptional regulator	NA	NA	NA	NA
WP_088305587.1\|5246_5699_+	hypothetical protein	NA	NA	NA	NA
WP_088305586.1\|6054_6372_+	DUF732 domain-containing protein	NA	NA	NA	NA
WP_163670439.1\|6404_7022_-	hypothetical protein	NA	NA	NA	NA
WP_163670729.1\|7002_7296_-	DUF4333 domain-containing protein	NA	NA	NA	NA
WP_163670441.1\|7564_8986_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_163670731.1\|9274_10963_+	hypothetical protein	NA	NA	NA	NA
WP_163670443.1\|11019_11592_-	hypothetical protein	NA	NA	NA	NA
WP_163670445.1\|12213_12360_-	hypothetical protein	NA	NA	NA	NA
WP_163670733.1\|12638_13853_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_163670447.1\|14060_15140_-	WGR domain-containing protein	NA	NA	NA	NA
WP_163670449.1\|15381_15573_+	hypothetical protein	NA	NA	NA	NA
WP_163670450.1\|15696_16512_+	HEAT repeat domain-containing protein	NA	NA	NA	NA
WP_163670451.1\|18337_18832_-	HNH endonuclease	A0A1P8DIY8	Virus_Rctr197k	4.2e-18	36.2

DBSCAN-SWA_2

35303 : 35759

Sinorhizobium_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_163670469.1\|35303_35759_-	TerB family tellurite resistance protein	A0A1Y0T181	Sinorhizobium_phage	1.5e-06	28.2

DBSCAN-SWA_3

48571 : 52808

Saccharomonospora_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_163670492.1\|48571_49684_-	DNA cytosine methyltransferase	I4AZL4	Saccharomonospora_phage	5.4e-29	30.8
WP_163670494.1\|49905_50442_-	hypothetical protein	NA	NA	NA	NA
WP_163670496.1\|50634_51183_+	hypothetical protein	NA	NA	NA	NA
WP_163670498.1\|51201_51369_-	hypothetical protein	NA	NA	NA	NA
WP_088304775.1\|51504_51831_-	hypothetical protein	NA	NA	NA	NA
WP_163670500.1\|52028_52808_-	hypothetical protein	A0A0M4R280	Mycobacterium_phage	1.6e-40	42.9

DBSCAN-SWA_4

61490 : 66191

Klebsiella_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_163670506.1\|61490_66191_-	methyltransferase domain-containing protein	A0A248SL14	Klebsiella_phage	1.1e-155	28.9

DBSCAN-SWA_5

71430 : 78286

Pseudomonas_phage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_088304755.1\|71430_72660_-	hypothetical protein	C8ZKD3	Pseudomonas_phage	2.5e-19	28.8
WP_088304803.1\|72659_73763_-	AAA family ATPase	H6WG28	Cyanophage	1.2e-17	27.2
WP_088304754.1\|74002_74278_+	hypothetical protein	NA	NA	NA	NA
WP_088304753.1\|74377_75499_+	ImmA/IrrE family metallo-endopeptidase	A0A0U4JD08	Gordonia_phage	4.8e-09	27.8
WP_133062541.1\|75700_76525_+	hypothetical protein	NA	NA	NA	NA
WP_088304751.1\|76571_76976_-	hypothetical protein	NA	NA	NA	NA
WP_163670519.1\|76975_78286_-	hypothetical protein	A0A1B0V7U9	Roseobacter_phage	4.4e-14	26.8

DBSCAN-SWA_6

81876 : 82074

Mycobacterium_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_064915233.1\|81876_82074_-	helix-turn-helix domain-containing protein	S5Y3R7	Mycobacterium_phage	7.1e-09	60.3

DBSCAN-SWA_7

96363 : 103646

Mycobacterium_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_133062591.1\|96363_97080_-	hypothetical protein	A0A2P1JXR4	Rhodococcus_phage	3.2e-14	38.1
WP_088305708.1\|97310_97805_+	hypothetical protein	A0A142F2K8	Mycobacterium_phage	1.6e-49	58.7
WP_088305624.1\|97817_98330_+	hypothetical protein	NA	NA	NA	NA
WP_088305625.1\|98638_99082_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_088305709.1\|99318_100263_-	DNA ligase	A0A076GD42	Sinorhizobium_phage	2.3e-36	36.3
WP_088305626.1\|100534_100801_+	hypothetical protein	NA	NA	NA	NA
WP_088305627.1\|100943_101393_+	Lsr2 family protein	NA	NA	NA	NA
WP_088305628.1\|101939_102287_-	hypothetical protein	NA	NA	NA	NA
WP_088305629.1\|102321_102618_-	hypothetical protein	NA	NA	NA	NA
WP_163670546.1\|102680_103646_-	alpha/beta fold hydrolase	A0A249XPN5	Mycobacterium_phage	7.8e-08	33.8

DBSCAN-SWA_8

107613 : 118374

Mycobacterium_phage(71.43%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_088305636.1\|107613_108561_-	hypothetical protein	A0A2D1G9W6	Mycobacterium_phage	2.4e-54	44.4
WP_088305637.1\|108841_109240_-	hypothetical protein	G1JX69	Mycobacterium_phage	1.8e-27	49.2
WP_088305639.1\|109542_110082_-	DUF1643 domain-containing protein	A0A142F2K6	Mycobacterium_phage	4.9e-60	68.9
WP_088305640.1\|110086_110299_-	hypothetical protein	NA	NA	NA	NA
WP_088305641.1\|110651_112502_-	DNA cytosine methyltransferase	A0A0K1Y7T4	Mycobacterium_phage	9.2e-50	30.7
WP_163670548.1\|112629_112905_-	hypothetical protein	NA	NA	NA	NA
WP_088305642.1\|112934_113783_-	hypothetical protein	NA	NA	NA	NA
WP_163670550.1\|114093_114339_-	hypothetical protein	NA	NA	NA	NA
WP_133062593.1\|114415_115075_-	hypothetical protein	NA	NA	NA	NA
WP_088305645.1\|115110_115653_-	adenine methyltransferase	A0A142KAC0	Gordonia_phage	3.0e-49	65.5
WP_163670742.1\|115834_116527_-	NYN domain-containing protein	NA	NA	NA	NA
WP_163670552.1\|116778_117366_-	hypothetical protein	NA	NA	NA	NA
WP_088305647.1\|117475_117907_-	hypothetical protein	W8EHE6	Mycobacterium_phage	8.4e-55	66.7
WP_133062594.1\|117903_118374_-	hypothetical protein	A0A1B3AZJ2	Gordonia_phage	3.9e-13	35.9

DBSCAN-SWA_9

123855 : 127149

Mycobacterium_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_163670558.1\|123855_124455_-	AAA family ATPase	A0A291I9W7	Mycobacterium_phage	2.8e-16	37.0
WP_133062599.1\|124455_125412_-	hypothetical protein	NA	NA	NA	NA
WP_163670560.1\|125504_125729_-	hypothetical protein	NA	NA	NA	NA
WP_088305660.1\|125862_126213_+	hypothetical protein	NA	NA	NA	NA
WP_133062600.1\|126345_126546_+	hypothetical protein	NA	NA	NA	NA
WP_170309467.1\|126643_126820_+	hypothetical protein	A0A1L6BXV8	Mycobacterium_phage	1.3e-06	49.1
WP_163670562.1\|126951_127149_+	hypothetical protein	V5UPE3	Mycobacterium_phage	3.6e-05	56.8

DBSCAN-SWA_10

143446 : 147013

Gordonia_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_163670603.1\|143446_144949_-	IMP dehydrogenase	R4TW99	Phaeocystis_globosa_virus	1.4e-24	30.8
WP_163670604.1\|145182_146331_-	hypothetical protein	NA	NA	NA	NA
WP_163670605.1\|146414_146813_-	type II toxin-antitoxin system death-on-curing family toxin	A0A1B3AYM0	Gordonia_phage	8.9e-27	53.1
WP_163670607.1\|146809_147013_-	antitoxin Phd	A0A1B3AYL7	Gordonia_phage	1.1e-07	53.8

DBSCAN-SWA_11

155209 : 160232

Mycobacterium_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_163670625.1\|155209_155602_-	hypothetical protein	A0A1C9M1F0	Mycobacterium_phage	2.9e-06	46.7
WP_163670627.1\|155871_156234_+	hypothetical protein	NA	NA	NA	NA
WP_163670436.1\|156796_156949_+	hypothetical protein	NA	NA	NA	NA
WP_163670629.1\|156958_157216_+	hypothetical protein	NA	NA	NA	NA
WP_163670631.1\|158003_158480_+	hypothetical protein	G1JS68	Mycobacterium_phage	4.2e-23	60.9
WP_170309468.1\|158482_159061_+	3'-5' exoribonuclease	A0A097EVM2	Mycobacterium_phage	4.4e-51	59.8
WP_163670636.1\|159680_160232_+	DUF4326 domain-containing protein	A0A1D8EX70	Mycobacterium_phage	2.0e-16	37.7

DBSCAN-SWA_12

163236 : 163806

Enterococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_163670640.1\|163236_163806_+	LemA family protein	A0A0C5K8T5	Enterococcus_phage	1.3e-07	24.6

DBSCAN-SWA_13

169941 : 171736

Acinetobacter_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_088305706.1\|169941_171078_-	DUF475 domain-containing protein	A0A172Q0Y5	Acinetobacter_phage	8.4e-62	43.5
WP_064915375.1\|171160_171736_-	TerD family protein	K4JRX3	Caulobacter_phage	4.6e-32	39.3

DBSCAN-SWA_14

175582 : 178863

Acinetobacter_phage(50.0%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_163670644.1\|175582_176695_+\|protease	cysteine protease StiP family protein	A0A172Q0S8	Acinetobacter_phage	1.4e-29	29.2
WP_064915370.1\|176691_177528_+	hypothetical protein	NA	NA	NA	NA
WP_163670646.1\|177579_178863_+	TerD family protein	K4JRX3	Caulobacter_phage	3.6e-08	30.4

DBSCAN-SWA_15

184221 : 191035

Mycobacterium_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_064915063.1\|184221_185022_-	DUF5131 family protein	W0LPY2	Mycobacterium_phage	8.3e-48	42.0
WP_131813198.1\|185076_185823_-	hypothetical protein	NA	NA	NA	NA
WP_074412549.1\|185986_187711_-	diguanylate cyclase	G3MA91	Bacillus_virus	1.3e-18	33.5
WP_088305260.1\|187875_189066_+	3-oxoacyl-ACP synthase	NA	NA	NA	NA
WP_088305259.1\|189205_189694_-	hypothetical protein	NA	NA	NA	NA
WP_081285420.1\|190336_191035_+	hypothetical protein	A0A0A7RVN9	Mycobacterium_phage	3.3e-08	46.4

DBSCAN-SWA_16

199804 : 200704

Mycobacterium_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_064915427.1\|199804_200704_-	hypothetical protein	A0A222ZMF8	Mycobacterium_phage	1.7e-41	46.0

DBSCAN-SWA_17

206765 : 214365

Pandoravirus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_163670650.1\|206765_208829_-	protein kinase	A0A0B5J6A8	Pandoravirus	1.0e-17	31.3
WP_131813242.1\|208869_210021_-	hypothetical protein	NA	NA	NA	NA
WP_074412559.1\|210167_210860_+	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	NA	NA	NA	NA
WP_163670653.1\|210921_214365_+	sensor domain-containing protein	A0A2R8FG22	Brazilian_cedratvirus	3.2e-27	37.2

DBSCAN-SWA_18

219645 : 220808

Acinetobacter_phage(100.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_163670657.1\|219645_220808_-\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	2.4e-32	33.0

DBSCAN-SWA_19

224312 : 227178

Mycobacterium_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_064915404.1\|224312_225293_-	DUF2637 domain-containing protein	A0A1D8ERY5	Mycobacterium_phage	1.0e-10	35.7
WP_064915405.1\|225438_227178_-	type VII secretion AAA-ATPase EccA	V5UQM2	Mycobacterium_phage	8.1e-56	31.2

DBSCAN-SWA_20

238334 : 245188

Mycobacterium_phage(66.67%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_064915415.1\|238334_239708_-\|protease	type VII secretion-associated serine protease mycosin	V5UPA7	Mycobacterium_phage	1.3e-69	43.0
WP_064915416.1\|239697_240405_-	hypothetical protein	NA	NA	NA	NA
WP_131813264.1\|240401_241796_-	hypothetical protein	NA	NA	NA	NA
WP_064915418.1\|241969_242416_+	helix-turn-helix transcriptional regulator	A0A2H4PEA4	Mycobacterium_phage	2.8e-05	36.6
WP_064915419.1\|242453_242849_-	hypothetical protein	NA	NA	NA	NA
WP_064915420.1\|243456_243855_-	hypothetical protein	NA	NA	NA	NA
WP_163670672.1\|244204_245188_-	AAA family ATPase	H7BUL8	unidentified_phage	2.5e-09	26.7

DBSCAN-SWA_21

249155 : 253727

Mycobacterium_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_064915513.1\|249155_249536_-	Lsr2 family protein	A0A222ZMT6	Mycobacterium_phage	4.3e-10	36.8
WP_163670674.1\|249569_251462_-	type VII secretion protein EccCb	R4JMR0	Bacillus_phage	5.8e-07	26.8
WP_163670676.1\|251489_253727_-	type VII secretion protein EccCa	V5UPA0	Mycobacterium_phage	3.0e-55	27.5

DBSCAN-SWA_22

258897 : 260678

Streptomyces_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_064915503.1\|258897_259914_-	C40 family peptidase	A0A2H5BMT3	Streptomyces_phage	2.4e-15	43.6
WP_081285425.1\|259913_260678_-	transglycosylase SLT domain-containing protein	A0A2H4J5G2	uncultured_Caudovirales_phage	2.4e-12	45.3

DBSCAN-SWA_23

274691 : 275456

Gordonia_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_074412575.1\|274691_275456_-	transcriptional regulator	A0A142K9K1	Gordonia_phage	6.4e-05	36.6

DBSCAN-SWA_24

280526 : 282212

Streptococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_081285411.1\|280526_282212_+	replicative DNA helicase	A0A1P8VVQ6	Streptococcus_phage	5.8e-67	31.1

DBSCAN-SWA_25

287661 : 296043

environmental_halophage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_163670696.1\|287661_288978_+	LysR family transcriptional regulator	Q2XUX1	environmental_halophage	3.4e-06	28.9
WP_163670712.1\|289111_290212_+	hypothetical protein	NA	NA	NA	NA
WP_163670745.1\|290350_290953_+	DUF433 domain-containing protein	A0A1W6JRB2	Corynebacterium_phage	3.5e-51	54.0
WP_163670714.1\|290949_291402_+	hypothetical protein	A0A0U4AZ46	Gordonia_phage	5.2e-07	29.9
WP_163670716.1\|291627_292143_+	NYN domain-containing protein	NA	NA	NA	NA
WP_163670717.1\|292142_294230_+	N-6 DNA methylase	NA	NA	NA	NA
WP_163670719.1\|294306_296043_+	N-6 DNA methylase	A0A220A2U4	Liberibacter_phage	1.6e-32	32.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_AP022565

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_AP022565_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022565_1

1450973-1451052

Orphan

Consensus_repeat	Method
GGCGGCTGACTGAGCGCTCGCGCGAAG	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_AP022565_1

>merge|NZ_AP022565|1|1450973-1451052|CRISPRCasFinder
GGCGGCTGACTGAGCGCTCGCGCGAAGGCAGGCCGCCGACCCGACAACACCGCGGCGGCTGACTGAGCGCTCGCGCGAAG

>NZ_AP022565|1|1|1450973-1451052|CRISPRCasFinder
GGCGGCTGACTGAGCGCTCGCGCGAAG	GCAGGCCGCCGACCCGACAACACCGC
GGCGGCTGACTGAGCGCTCGCGCGAAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022565.1\|WP_163662335.1\|1447396_1449202_+\|N-acetylglutaminylglutamine-amidotransferase	unknown	unknown	gnl\|CDD\|274430
NZ_AP022565.1\|WP_163662327.1\|1438719_1440084_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|365919
NZ_AP022565.1\|WP_163662341.1\|1452379_1453885_-\|cobyric-acid-synthase	unknown	unknown	gnl\|CDD\|234838
NZ_AP022565.1\|WP_163662346.1\|1454869_1455250_+\|hotdog-fold-thioesterase	unknown	unknown	gnl\|CDD\|239527
NZ_AP022565.1\|WP_163662344.1\|1453895_1454753_-\|type-I-methionyl-aminopeptidase	unknown	unknown	gnl\|CDD\|237252
NZ_AP022565.1\|WP_163662331.1\|1442382_1443972_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|273331
NZ_AP022565.1\|WP_163662323.1\|1437202_1437928_-\|FCD-domain-containing-protein	unknown	unknown	gnl\|CDD\|225097
NZ_AP022565.1\|WP_163662325.1\|1437945_1438719_-\|3-oxoacyl-ACP-reductase	unknown	unknown	gnl\|CDD\|180371
NZ_AP022565.1\|WP_163662338.1\|1451067_1451631_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_AP022565.1\|WP_163662333.1\|1443972_1447299_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223627
NZ_AP022565.1\|WP_163662321.1\|1436863_1437193_-\|metalloregulator-ArsR/SmtB-family-transcription-factor	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|223713
NZ_AP022565.1\|WP_163662351.1\|1455874_1457698_-\|penicillin-binding-transpeptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|223839
NZ_AP022565.1\|WP_163662353.1\|1457783_1458638_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|225928
NZ_AP022565.1\|WP_163662329.1\|1440825_1442193_-\|glutamine-synthetase	unknown	unknown	gnl\|CDD\|223252
NZ_AP022565.1\|WP_163662357.1\|1459872_1461093_-\|site-2-protease-family-protein	unknown	unknown	gnl\|CDD\|308008
NZ_AP022565.1\|WP_163662355.1\|1458693_1459860_-\|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	unknown	unknown	gnl\|CDD\|234737
NZ_AP022565.1\|WP_163669691.1\|1440080_1440800_-\|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|224982
NZ_AP022565.1\|WP_163662340.1\|1451695_1452370_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022565.1\|WP_163662348.1\|1455263_1455851_-\|DUF1707-domain-containing-protein	unknown	unknown	gnl\|CDD\|377959
NZ_AP022565.1\|WP_163662319.1\|1435698_1436805_-\|HoxN/HupN/NixA-family-nickel/cobalt-transporter	unknown	unknown	gnl\|CDD\|225911

Protein	Function_ID	Function_description	E-value
NZ_AP022565.1\|WP_163662335.1\|1447396_1449202_+\|N-acetylglutaminylglutamine-amidotransferase	gnl\|CDD\|274430	TIGR03104, trio_amidotrans, asparagine synthase family amidotransferase. Members of this protein family are closely related to several isoforms of asparagine synthetase (glutamine amidotransferase) and typically have been given this name in genome annotation to date. Each is part of a conserved three-gene cassette sparsely distributed across at least twenty different species known so far, including alpha, beta, and gamma Proteobacteria, Mycobacterium, and Prosthecochloris, which is a member of the Chlorobi. The other two members of the cassette are a probable protease and a member of the GNAT family of acetyltransferases.	0
NZ_AP022565.1\|WP_163662327.1\|1438719_1440084_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|365919	pfam00171, Aldedh, Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.	0
NZ_AP022565.1\|WP_163662341.1\|1452379_1453885_-\|cobyric-acid-synthase	gnl\|CDD\|234838	PRK00784, PRK00784, cobyric acid synthase.	0
NZ_AP022565.1\|WP_163662346.1\|1454869_1455250_+\|hotdog-fold-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	1.20429e-24
NZ_AP022565.1\|WP_163662344.1\|1453895_1454753_-\|type-I-methionyl-aminopeptidase	gnl\|CDD\|237252	PRK12896, PRK12896, methionine aminopeptidase; Reviewed.	1.10082e-157
NZ_AP022565.1\|WP_163662331.1\|1442382_1443972_+\|amino-acid-permease	gnl\|CDD\|273331	TIGR00907, Choline_transport_protein, amino acid permease (GABA permease). [Transport and binding proteins, Amino acids, peptides and amines].	4.23939e-78
NZ_AP022565.1\|WP_163662323.1\|1437202_1437928_-\|FCD-domain-containing-protein	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	5.62932e-32
NZ_AP022565.1\|WP_163662325.1\|1437945_1438719_-\|3-oxoacyl-ACP-reductase	gnl\|CDD\|180371	PRK06057, PRK06057, short chain dehydrogenase; Provisional.	5.36469e-176
NZ_AP022565.1\|WP_163662338.1\|1451067_1451631_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	6.35527e-05
NZ_AP022565.1\|WP_163662333.1\|1443972_1447299_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223627	COG0553, HepA, Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair].	1.92578e-107
NZ_AP022565.1\|WP_163662321.1\|1436863_1437193_-\|metalloregulator-ArsR/SmtB-family-transcription-factor	gnl\|CDD\|223713	COG0640, ArsR, Predicted transcriptional regulators [Transcription].	6.65089e-14
NZ_AP022565.1\|WP_163662351.1\|1455874_1457698_-\|penicillin-binding-transpeptidase-domain-containing-protein	gnl\|CDD\|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	2.24655e-68
NZ_AP022565.1\|WP_163662353.1\|1457783_1458638_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|225928	COG3393, COG3393, Predicted acetyltransferase [General function prediction only].	1.45231e-65
NZ_AP022565.1\|WP_163662329.1\|1440825_1442193_-\|glutamine-synthetase	gnl\|CDD\|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	2.92237e-143
NZ_AP022565.1\|WP_163662357.1\|1459872_1461093_-\|site-2-protease-family-protein	gnl\|CDD\|308008	pfam02163, Peptidase_M50, Peptidase family M50.	3.4225e-56
NZ_AP022565.1\|WP_163669691.1\|1440080_1440800_-\|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	gnl\|CDD\|224982	COG2071, COG2071, Predicted glutamine amidotransferases [General function prediction only].	1.73043e-89
NZ_AP022565.1\|WP_163662355.1\|1458693_1459860_-\|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	gnl\|CDD\|234737	PRK00366, ispG, flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase.	0
NZ_AP022565.1\|WP_163662348.1\|1455263_1455851_-\|DUF1707-domain-containing-protein	gnl\|CDD\|377959	pfam08044, DUF1707, Domain of unknown function (DUF1707). This domain is found in a variety of Actinomycetales proteins. All of the proteins containing this domain are hypothetical and probably membrane bound or associated. Currently, it is unclear to the function of this domain.	9.23362e-13
NZ_AP022565.1\|WP_163662319.1\|1435698_1436805_-\|HoxN/HupN/NixA-family-nickel/cobalt-transporter	gnl\|CDD\|225911	COG3376, HoxN, High-affinity nickel permease [Inorganic ion transport and metabolism].	6.22628e-114

>NZ_AP022565.1|WP_163662335.1|1447396_1449202_+|N-acetylglutaminylglutamine-amidotransferase
MCGAAGEVRLDGRTPDISAVSAMADAMAPRGPDAAGVWSQGRVALGHRRLKIIDLTEAGAQPMVDPELGLTVCWNGCIYNYQELRRELSGHGYRFFSHSDTEVLLKAYHHWGDRFVEHLMGMFAFAIVERDTGRVLLGRDRLGIKPLYITEDSHRIRFASSLPALLAGGGVDTRIDPIALHHYLTFHSVVPPPLTILQGIKKVPPASVVAIEPDGSRHTTVYWSPDFTRHSDRADWSEKDWEDAVLESLRRAVERRLVADVPVGCLLSGGVDSSLIVGLLAEAGQHGLSTFSIGFESVGGVAGDEFKYSDIIAEHFETDHHQIRIGTDRMLPALDGAISAMSEPMVSHDCVAFYLLSQEVSKHVKVVQSGQGADEVFAGYHWYPPMAEPGAAGLDGSVASYRGAFFDRDSTGVSALISESYLADGDPSGAFVTDHFAAAGAGTGVDRALRLDTTVMLVDDPVKRVDNMTMAWGLEGRVPFLDHELVELAATCPPGLKIAHGGKGVLKQAARRVVPAAVIDRPKGYFPVPALTHLEGPYLDLVRDALYAPEAKERGLFRPEAVDRLLADPNGRLTPLRGNELWQIALLELWLQRHGVTGASA
>NZ_AP022565.1|WP_163662333.1|1443972_1447299_-|DEAD/DEAH-box-helicase
MGPGFGFGIARDELIRDFGAQSTVRGERYAAEGRVRDVEFDADDRVLRGRCVGSHGQFYVLEVGLSAGSRAVVEWALCSCPVGSFCKHAVALVLTAAPADAAHEPVERWRYLLDKVLDEVAVPGGGGKPIALEFSIGAPTRYRPGTLLMLRPLTLGKRGTWITRALTWRRLADHPDAGEFDREQYRAVRALVSEMVRYSAPHSGEGMMLNGMPATLWPRLDEVLDAGVTILADPATGIRAVELAKNVHLRLDFAAEGGGGAVMSVSLIVDGQERDPAGVGLIGMPAPHGMFQVVDSVLRLGAFDPVPGRTMAELLGHHEQVHIPVDMARELAVDILPRLASSVDMEVADGLFVPPTITGPKPALTVKIVDGGARAFWSTRYEVNDQHHDFDPLSSAGLIGYRDPAAEEELWHRVLPALQVVAAAAQDWKRQATQHVNRRISTTLDAEAVHELRAIVNAVSAVDAVAVASQRTLLGGVTLTAVEAAVLCDQTLPQLSCYADLIVDADGRYRAAGADPVLSFSGDTSVPGDWFNLNVTVSVDGETVALPEVIRELASGATHMMLPSGIYFRLDTPELVRFRALLDEARALGEIDGDRVNAASLNVTLWDELLELGVVDEQLARWRANLGRLAAARPPAPIEPPVGLDADLRDYQRDGLDWLSFLWDNGIGGVLADDMGLGKTVQTLALIARAVSGGAGKFLVVAPTSVARNWVAECRKFAPGLNAVVVTSTNARAAIGLAEQVAAADIVVTSYTLLRMDVGAYSQIPWAGMVLDEAQFVKNHHSKTHQAARLLDVPFKLAITGTPMENNLMELWSLLSITVPGLFPSPKVFETYFRKPIESGQADDLLPVLRRRIKPVLLRRTKGQVLTELPPKSEQVLTIGLSAKHRKIYDTRLARERQKVLGLLGDWEKNRFQIFRSLTLLRQLSLHPGLVDDSARSIGSAKIDFLVEQLDQLVAEGHSALVFSQFTGFLGIVRAHLDSAGTAYSYLDGSVDSDGRARAIEEFDAGSKQVFLISLKAGGFGLNLTAADYCFLCDPWWSPAAEAQAVDRAHRIGQARPVTVYRLVAENTIEEKVVALQDRKRALFAAVVDDGDLFGSAVTASDIRELLG
>NZ_AP022565.1|WP_163662331.1|1442382_1443972_+|amino-acid-permease
MPEGHEELTEHLTDDEEHLAKLGYVQELQRSWSGFSNFAISFSIISILAGCFTSFGLGWNNGGPAAIAWGWPIVSCFILIIGFCLAELVSAYPTSGGIYWWASKLGGPKAGFYTGWLNLIGLVAILASVSYGSATFLDLTLGTFSESWLAGYSLTRVFIMFLIILAVSAVINIFSSHLLAVINNVSVWWHVAGATAVIAILWLLPDQHASASEVFAKTINNSGIFSGSTSGWGFLLFVLPISAILTQYTITGYDASAHLSEETKSAANAAAKGIWQSIFYSAIGGWILLLSFLFAVQNSDEVSANGGAVATIFTQALGSKWAGVVLLIATAGQLFCTTACQTSASRMLFAFSRDRAVPGHQLWSKVSASRVPANAVIVTAVIAAIITLPAIVPVKIPVNGVDVPSPVAFYAVVSIGVVGLYLCFAVPIYYRRKAGDSFEQGRWNVGDKYKWMAPVAIIEIVVTSIIAMFPTSLGGMPWDPSFEWKFVNYTPLLVGGVLVLLFLYWHVSVKHWFTGPIKQVDTSTTPVSG
>NZ_AP022565.1|WP_163662329.1|1440825_1442193_-|glutamine-synthetase
MSQNPGMLARADLERLVASGEIDTVIVAFCDMQGRLTGKRVSGRLFVEEVAAHGAECCNYLLAVDVDMNTVDGYSMSSWDTGYGDMVMTADFSTLRVVPWLPGTALVMADLSRLDGRAVEQAPRSILNRQIDRLAERKLVPYVGTELEFMVFDNTFREAWAAGYRDLTPASDYNVDYSMMASSRMEPLLRDIRRGMEGAGLYCEGVKGECNLGQQEIAFRYDHARNTCDNHTIYKNGAKEIADQHGKSLTFMAKFDEREGNSCHIHISLRGDDGSLVFADESGPHGMSSMFRSFIAGQLATLRELTLFHAPNINSYKRFSDGSFAPTAIAWGMDNRTCALRVVGHGSGMRVECRAPGGDVNQYLAVSALIAGGLYGIDHELELPEALPGNAYASEAQRLPTTLAEAAELFEKSEVARTAFGDDVVEHYLNNARVELAAFNSAVTDWERVRGFERL
>NZ_AP022565.1|WP_163669691.1|1440080_1440800_-|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein
MTTYLQQAQTGVWDVPASFLPQVYFEGVTRAGGIALLLPPQPVDDEIADRVLDRVDGLVITGGPDVDPRRYGQQAHPATNAPATGRDAWEFALLEAALRRDIPVLGVCRGAQVLNTALGGTLHQHLPEVIGHSHHQKGDAVFGTSAVHTVPDTRLAALIGATSDAQCYHHQAIDRLGAGLVVSARDSDGVIEAVERDPALSGDVFVLGVQWHPEESLDDLRLFTAVVDAARIYATERVS
>NZ_AP022565.1|WP_163662327.1|1438719_1440084_-|aldehyde-dehydrogenase-family-protein
MTSSQVINPATEEVLTTVQLCDVAGVDDAVARADVAQRAWARLAPADRAAALRAFAAVVDAHIDELAALEVANSGHPIGQAEWEAGHVRDVLQFYSATPERLSGKQIPVAGGLDVTFNEPLGTVGLITPWNFPMTIAAWGFAPALAAGNAVLLKPAEWTPLTSIRLGELAVESGLPAGLFQVLPGKGSVVGERFVTHPGVRKVVFTGSTTVGKRVMAGAAAQVKRVTLELGGKSANIVFDDCDLEKAAATAPYGVFDNAGQDCCARSRILVQRSVYDRFMELLEPAVKGVAVGDPTARNTEMGPLVSRPHWESVSSYVPDDAPVAFRGSTPEGPGFWFPPTVLTPQRTDRTVTDEIFGPVVTVLAFEDEADAIALANDTPYGLSGSVWTDNLSRAMRVSRAVESGNLSVNSHSSVRYNTPFGGFKQSGLGRELGPDAPLSFTETKNVFFAVEEL
>NZ_AP022565.1|WP_163662325.1|1437945_1438719_-|3-oxoacyl-ACP-reductase
MDLTQRLAGKVAVITGGAGGIGLATGRRLRAEGATIVVGDIDAATGEAAAEELDGLFIGVDVSDQDAVDHLFDTAAATFGSVDIAFNNAGISPPEDDLIETTELPAWQRVQDINLKSVYLSCRAALRHMVPAGKGSIINTASFVAVMGSATSQISYTASKGGVLAMSRELGVQYARQGIRVNALCPGPVNTPLLQELFAKDPERAARRLVHIPVGRFAEPEELAAAVAFLASDDASFITGSTFLVDGGISSAYVTPL
>NZ_AP022565.1|WP_163662323.1|1437202_1437928_-|FCD-domain-containing-protein
MTAEPDPQQPAAGALLRPVRLGNAFEDTVGRLLETIRLGVLSPGESLPPERELATRLGVSRDTVREAIKSLADAGYLVSKRGRYGGTFLTDEVPRHTADGPSPTGEEIDDVLRLREILEVGAARMAAGRTLSAAERDGLWSRLADVRAAEPADYRRLDSRLHLAIAAAAGSPSLVPLIAENRMRINALLDQIPLLARNIAHSDEQHEAIVMAILAGDGERAAAAMLAHVGGSSALLHGFLD
>NZ_AP022565.1|WP_163662321.1|1436863_1437193_-|metalloregulator-ArsR/SmtB-family-transcription-factor
MHQHGKEVQVERASSALTDVDTPGWAQRFDLLSDPHRLEILLGLHRVPGICVSDLATALGRSENSVSQALRVLREQGWVTSTRVGRTVNYRLEDETVHDLLHWIGARHG
>NZ_AP022565.1|WP_163662319.1|1435698_1436805_-|HoxN/HupN/NixA-family-nickel/cobalt-transporter
MTIGAPPATARSARLATSFGRADWTSIAAVAAVVLVLHVIGWGVLIFGVAPQHISLGSAGVFGVGLGVTAYLLGVRHAFDADHIAVIDNTTRKLVGEGTRSVSAGFWFSLGHSSVVFGLALLLALGVRALVGPVQDENSATLQALGLIGSLVAGTFLILIGLTNLVAAVGIAKVFRAMRTGDFDEAELERQLNSRGFVARLLSRVMRRVNKPWHLYPVGFLMGLGFDTASQVALLVLAAGTAAFTLPWYAMLVLPVLFAAGMSLFDSADGIFMARAYGWAFLQPVRKVYYNLTVTVLSVIVALGIGAIVLTGLLVERLDITTGPLAFVGSADLKFVGYAIVGLFALSWGVALGIWRFGRIEQRWSAQA
>NZ_AP022565.1|WP_163662338.1|1451067_1451631_-|alpha/beta-hydrolase
MLTTVATIDGFTTPVDVSGPEKGSTVVVLSAGHHGPAAYEQICRRLHTASLRTVIIGPDPRLTAKSVVGILDSLDIKWALLVGDRLGGELAWELAATRLDKFIGLVVVDRGHPRVADSTGVIRDDECPPVEMNTTVLVSNPAARAVAKASQRYVYGDFRLVEMPGRRNAGDSTAQLAAEIVLRTSSW
>NZ_AP022565.1|WP_163662340.1|1451695_1452370_-|hypothetical-protein
MSRRHRLVAGLVGLVALVTVSGCSPVVAGSPTWPGAILEQVLLTAADFPPGVQFDRVSADGSGPGGSGGPAPMLSTPAGCSDGLTRVIAESAERGPGSAAQFIAAYDGARMVLTVMTAPLPLDRLAATAQRCAQFSTYFDPSDQGIPMTTTKLATPRTSALAYQQTMRLGGVEHSIFFAFENVGNWAVFGIAFPTQNPSIVAKGALPQTFLDVFGIQARRLDAR
>NZ_AP022565.1|WP_163662341.1|1452379_1453885_-|cobyric-acid-synthase
MSGALLVAGTTSDAGKSMVVAGLCRLLARTGVSVAPFKAQNMSNNSAVTVDGGEIGRAQAMQARASGLAPSIRFNPILLKPGGDRTSQLVIRGQVAGTVAAGDYFTHRDRLAAVVADELATLRSEFDVVICEGAGSPAEINLRATDLANMGLARAADLPVIVVGDIDRGGLLAHLHGTVAVLAPEDQALIAGFVVNKFRGDPSLLEPGLRQLLELTGRPNYGVIPFDDGIWLDTEDSVSVRPGGLVGTPQPPRGAQTLTVAALRLPRISNSTDIEALACEPGVVVRWVADAADLAGVDLVVIPGSKATVSDLAWLRQRGLAAAILDHAAQGRPVLGVCGGFQMLCRRIDDAVEAGAAGGASVEGLGLLDADIEFAPDKTLRHWENPLWGYEIHHGQVTRTAADDWLGVGLRCGAVYGTHWHGLLDNDHVRRAWLTEIAADAGRVGFVVADDIDVQGRRDAQLDLMADLLAAHLDIAAVMDLVQHGPPPRPAMTTALVGPPR
>NZ_AP022565.1|WP_163662344.1|1453895_1454753_-|type-I-methionyl-aminopeptidase
MPVRTALRPGVQSPTLPVPKSIPRPEYAWKSTVQEGSEPWVQTPEVIEKMRVAGRIAAAALAEAGKAVAPGVTTDELDRIAHDYMIDHGAYPSTLGYKSFPKSCCTSLNEVICHGIPDSTVIEDGDIVNIDVTAYINGVHGDTNATFLAGDVSEEHRLLVERTHEATMRAIKAVKPGRALSIVGRVIEAYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETVLEPGMTFTIEPMINLGSLDYEIWGDDWTVVTKDGKWTAQFEHTLVVTEDGAEILTLP
>NZ_AP022565.1|WP_163662346.1|1454869_1455250_+|hotdog-fold-thioesterase
MTETAHVLQLLDYREVESSADRLVLEMDNRPDLANVRGALQGGLVATLIDIAAGMLAGNASGVGYDVTTADLNIHFLAPIMGTARAEAKVVRAGRRLIVTSVDVTDIDRDRLAARATLTFAVLEPR
>NZ_AP022565.1|WP_163662348.1|1455263_1455851_-|DUF1707-domain-containing-protein
MTGINEQSVDLRVSDADRNGTMRRLHNAVALGLIDIAEFEERSAMVSLARLHSDLDALVGDLPGPGAIVTTATDRVELRGVLGSLKRQGEWTVPTRLALVRRMGSVELDLTRARFAGPMVVIELDMKFGSLEIRLPEGASASIDDVEVIVGSADDHRRDAPADGAPHIILTGKVVCGSVDIRGPRRNWKLTLRRS
>NZ_AP022565.1|WP_163662351.1|1455874_1457698_-|penicillin-binding-transpeptidase-domain-containing-protein
MATQTSSVTRTTGLLMVIAVAGATALSACTPRPDGPESAAEQFFAALATGDTAAAAALADRPDEAKTALSEAWSGVQATRLDAQILGSKYTGDTGSVAYRYTWHLPKNRTWTYDGQLNLIREEGRWEVRWSATGLHPKLGEHQTFALRADAPRRASVNERGGTDVLVPGYIYAYGLDARAAGSALMPTARAVADTLRGFDPALGDPQRLAEQASSSAQPMSLITLRQSDNDRIAPAIGRLPGVVITPQPEMLPTDETFAPAIVNEVKNSVAGQLDGQPGWRVVSVNQNGVDVEVLNEVAGDPAPSITISLDRAVQDAAQNAVNTTGKQAMIVALKPSTGEILAVAQNAAADAAGPLATMGQFPPGSTFKMVTAGAAIERDMATPNTLLGCPGTLDIGHRTVTNYDAFDLGAVPMSRAFANSCNTTFGELASRMPPRGLTQAAARYGIGTDYQVDGITTLTGSVPPTVDLAERTEDGFGQGKVLVSPFGMALAAATVAAGRTPVPRLIEGRQTMVDGAGAPITPKMVDGLRPMMRLVVTNGTAKDLNGLGDVRGKTGEAEFMGGSHSWFAGYRGDMAFAALIVGGGSSEYAVRMCKTMFDGLPPAYLA
>NZ_AP022565.1|WP_163662353.1|1457783_1458638_-|GNAT-family-N-acetyltransferase
MSAPPLFRLVDERRVSVVRDATPCLQVFDEDPVGSCMVAARVAEFGVEHGAIGGELWTRRGVTESLCYAGPNLIPLRGDTEDLKAFSDKAMSSARRCSSVVGRAELVLPMWRRLETVWGTARDVREQQPLMALNSMPECPIDPAVRPVRMDELDTYLVAAIDMFIGEVGVDPRLGDGGTGYRRRIAGLIAAGRAWARFEHGEVVFKAEVGSQSPTVGQIQGVWVHPEWRGRGLGVSGTAAMAAAVVASGRIASLYVNSYNTVARATYARIGFEQVGTFATILLD
>NZ_AP022565.1|WP_163662355.1|1458693_1459860_-|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase
MTSIGLGMPAPPAPTLAPRRKTRQLDVGGVGVGSEHPIAVQSMCTTKTHDVNATLQQIAELTASGCDIVRVACPRQEDADALAEIARHSQIPVIADIHFQPKYIFAAIDAGCAAVRVNPGNIKEFDGRVKEVAKAAGDAGIPIRIGVNAGSLDPRLMQKYGKATPEALVESALWEASLFEEHGYGDIKISVKHNDPVIMVEAYRQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSQGIGDTIRVSLSAPPAEEVKVGNQILESLNLRPRGLEIVSCPSCGRAQVDVYTLANAVSAGLDGLDVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGEVIKTVPEAQIVETLIEEAMRLAAEMGTEAGSDDASGSPVVTVS
>NZ_AP022565.1|WP_163662357.1|1459872_1461093_-|site-2-protease-family-protein
MMFAIGIALFALAILVSVALHECGHMWVARATGMKVRRYFVGFGPTLWSTRRPNRLGETEYGIKAIPLGGFCDIAGMTSVDEIAPEDRPYAMYKQKVWKRVAVLFAGPAMNFILGFVLLYAVAIMWGLPNINQPITAKVGETGCVAAQLSLDKMGECTGPGPAALAGIQAGDEIVKVGDTPVSDFKQMATEIRKLNGPVSIELKRDGQTITTVVDVTQTKRFTSTEATEPTTVGAIGVSEARGEPPTPYNAITAVPATVSFTGDLAVELGKSLAKIPTKIGALVEAIGGGERDKETPISVVGASIIGGETVEAGLWVAFWFFLAQLNFVLGAINLVPLLPFDGGHIAVATYEKIRNMIRAARGKVAAGPVNYLKLMPATYVVLLVVVSYMLLTVTADLVNPLSIFD

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Crispr_ID: NZ_AP022565_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022565_2

3149678-3149845

Orphan

Consensus_repeat	Method
AAGCGTCCCGGCGCCAAGAAGGCCGCGGCACCCGCGGCCTCGGCGGCACCCGCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022565_2

>merge|NZ_AP022565|2|3149678-3149845|CRISPRCasFinder
AAGCGTCCCGGCGCCAAGAAGGCCGCGGCACCCGCGGCCTCGGCGGCACCCGCTGCCGAAGCACCAGCCGCTCCCGCGGCTCCGGTGAAGGGGCTGGGCATGGCCGGCGGCGCCAAGCGTCCCGGCGCCAAGAAGACCGCGGCACCCGCGGCCTCGGCGGCACCCGCT

>NZ_AP022565|2|2|3149678-3149845|CRISPRCasFinder
AAGCGTCCCGGCGCCAAGAAGGCCGCGGCACCCGCGGCCTCGGCGGCACCCGCT	GCCGAAGCACCAGCCGCTCCCGCGGCTCCGGTGAAGGGGCTGGGCATGGCCGGCGGCGCC
AAGCGTCCCGGCGCCAAGAAGACCGCGGCACCCGCGGCCTCGGCGGCACCCGCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022565.1\|WP_163665298.1\|3160369_3160942_-\|dCTP-deaminase	unknown	unknown	gnl\|CDD\|234753
NZ_AP022565.1\|WP_163665297.1\|3158843_3160175_-\|ammonium-transporter	unknown	unknown	gnl\|CDD\|223083
NZ_AP022565.1\|WP_163665288.1\|3150621_3151911_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|181738
NZ_AP022565.1\|WP_163665294.1\|3153576_3154329_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|274422
NZ_AP022565.1\|WP_163665277.1\|3140646_3141777_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022565.1\|WP_170309401.1\|3154330_3155647_-\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_AP022565.1\|WP_163665267.1\|3127753_3133231_-\|PE-family-protein	unknown	unknown	unknown
NZ_AP022565.1\|WP_163665282.1\|3144612_3147105_+\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NZ_AP022565.1\|WP_163665271.1\|3135333_3137124_-\|Hsp70-family-protein	unknown	unknown	gnl\|CDD\|212667
NZ_AP022565.1\|WP_163665269.1\|3134334_3135270_+\|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|379128
NZ_AP022565.1\|WP_163665286.1\|3150193_3150415_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022565.1\|WP_163665292.1\|3153189_3153558_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|378915
NZ_AP022565.1\|WP_163665279.1\|3142062_3142611_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022565.1\|WP_163665281.1\|3142808_3144602_+\|Hsp70-family-protein	unknown	unknown	gnl\|CDD\|223520
NZ_AP022565.1\|WP_163665265.1\|3127255_3127744_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226406
NZ_AP022565.1\|WP_163665295.1\|3155685_3157017_-\|nucleotide-sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|223936
NZ_AP022565.1\|WP_163665296.1\|3157093_3158623_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237605
NZ_AP022565.1\|WP_163665275.1\|3138687_3140550_-\|dynamin-family-protein	unknown	unknown	gnl\|CDD\|223771
NZ_AP022565.1\|WP_163665273.1\|3137154_3138645_-\|dynamin-family-protein	unknown	unknown	gnl\|CDD\|223771
NZ_AP022565.1\|WP_163665290.1\|3151951_3153181_+\|YibE/F-family-protein	unknown	unknown	gnl\|CDD\|377940

Protein	Function_ID	Function_description	E-value
NZ_AP022565.1\|WP_163665288.1\|3150621_3151911_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|181738	PRK09265, PRK09265, aminotransferase AlaT; Validated.	0
NZ_AP022565.1\|WP_170309401.1\|3154330_3155647_-\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	2.67179e-86
NZ_AP022565.1\|WP_163665292.1\|3153189_3153558_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	0.000206924
NZ_AP022565.1\|WP_163665298.1\|3160369_3160942_-\|dCTP-deaminase	gnl\|CDD\|234753	PRK00416, dcd, deoxycytidine triphosphate deaminase; Reviewed.	3.20715e-98
NZ_AP022565.1\|WP_163665269.1\|3134334_3135270_+\|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	gnl\|CDD\|379128	pfam13338, AbiEi_4, Transcriptional regulator, AbiEi antitoxin. AbiEi_4 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	7.5231e-06
NZ_AP022565.1\|WP_163665271.1\|3135333_3137124_-\|Hsp70-family-protein	gnl\|CDD\|212667	cd10170, HSP70_NBD, Nucleotide-binding domain of the HSP70 family. HSP70 (70-kDa heat shock protein) family chaperones assist in protein folding and assembly and can direct incompetent "client" proteins towards degradation. Typically, HSP70s have a nucleotide-binding domain (NBD) and a substrate-binding domain (SBD). The nucleotide sits in a deep cleft formed between the two lobes of the NBD. The two subdomains of each lobe change conformation between ATP-bound, ADP-bound, and nucleotide-free states. ATP binding opens up the substrate-binding site; substrate-binding increases the rate of ATP hydrolysis. HSP70 chaperone activity is regulated by various co-chaperones: J-domain proteins and nucleotide exchange factors (NEFs). Some HSP70 family members are not chaperones but instead, function as NEFs to remove ADP from their HSP70 chaperone partners during the ATP hydrolysis cycle, some may function as both chaperones and NEFs.	2.2479e-30
NZ_AP022565.1\|WP_163665297.1\|3158843_3160175_-\|ammonium-transporter	gnl\|CDD\|223083	COG0004, AmtB, Ammonia permease [Inorganic ion transport and metabolism].	2.60727e-159
NZ_AP022565.1\|WP_163665294.1\|3153576_3154329_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	9.8026e-23
NZ_AP022565.1\|WP_163665282.1\|3144612_3147105_+\|LuxR-family-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	9.65772e-15
NZ_AP022565.1\|WP_163665281.1\|3142808_3144602_+\|Hsp70-family-protein	gnl\|CDD\|223520	COG0443, DnaK, Molecular chaperone [Posttranslational modification, protein turnover, chaperones].	3.90348e-32
NZ_AP022565.1\|WP_163665265.1\|3127255_3127744_+\|hypothetical-protein	gnl\|CDD\|226406	COG3889, COG3889, Predicted solute binding protein [General function prediction only].	1.2669e-07
NZ_AP022565.1\|WP_163665295.1\|3155685_3157017_-\|nucleotide-sugar-dehydrogenase	gnl\|CDD\|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	0
NZ_AP022565.1\|WP_163665296.1\|3157093_3158623_-\|hypothetical-protein	gnl\|CDD\|237605	PRK14086, dnaA, chromosomal replication initiator protein DnaA.	2.38478e-12
NZ_AP022565.1\|WP_163665275.1\|3138687_3140550_-\|dynamin-family-protein	gnl\|CDD\|223771	COG0699, COG0699, Predicted GTPases (dynamin-related) [General function prediction only].	1.8094e-29
NZ_AP022565.1\|WP_163665273.1\|3137154_3138645_-\|dynamin-family-protein	gnl\|CDD\|223771	COG0699, COG0699, Predicted GTPases (dynamin-related) [General function prediction only].	4.56098e-22
NZ_AP022565.1\|WP_163665290.1\|3151951_3153181_+\|YibE/F-family-protein	gnl\|CDD\|377940	pfam07907, YibE_F, YibE/F-like protein. The sequences featured in this family are similar to two proteins expressed by Lactococcus lactis, YibE and YibF. Most of the members of this family are annotated as being putative membrane proteins, and in fact the sequences contain a high proportion of hydrophobic residues.	1.6166e-75

>NZ_AP022565.1|WP_163665282.1|3144612_3147105_+|LuxR-family-transcriptional-regulator
MTAPEIVPELPVAARSAIDAVLANPADPVKLLLSGGIGTGKSTVLAQIRSALRDGGRTVLTRAPRPGDETEAAFVVDDADQLTDAEIDCLAEKVADTATTVVVVACEPLTHRPSLQALTTALERENPVLRLGPLPAAEVGRILTTAPGSAATVETVRSVLAATAGLPFLLRAAADAVEAPTDAARFALLQRLRRVDDATRDALLILSLSHDLGPDDVAAALRLTGAEASALVDRARAGGLVEPSHDRRFLRLLHESLAQIAGAARHHEIETSLLTSQLELSTLSADLAVRLAEHGLRDDRLAEALAEHAAHNRARPARAARLYRAAVTAGATAVSTRLADALALAGDCTTAARMADELLSSEDPSERATAVRVAGSVAMHDGGAAQAADLFRWLGPYPDTLISSAAVTSFLAAGDADAARASSRSEVAGPPTSTARAARSLAEGLVLSLDQPFAVTVARLGQAVTSEHQAGGVAPDTPAALVTLAALHGGDSVRARSVIGRAVRAGGTGEETFSAARHRLLLGWVKMQDGQLGAAGADAAAAEAGEDLHRRDALWAAALRTAIARRSGDSGAVQKHWYAAVEVLAEYSIDLFSLLPLGELWVAGARMRQVDRLEHTLSEAWSLLAGLGDPVLWSVPLHWAGVHAGILANSPGAVAPHGQALTAAASQSAFARALANAGRTWLRVLANHVDTDEVTTAARALSQFGLTWDGTRLASQAALQTPDARVSQAMLQLARDLKQTSAVEEVVLGSEPPTGSARQAPAPSSTKLSDREREVAELLLLGMPYRDIGSQLFISAKTVEHHVARIRRRLGAESRTEMLSMLRAMLAPPG
>NZ_AP022565.1|WP_163665281.1|3142808_3144602_+|Hsp70-family-protein
MTDALGLSIGMTNLVAAREGRQPVIRRSIFTLHNDRAPEVGEYTGGGLPLAGFVERVGDPVPLVAADGSQHRGELVLAEALDVMARAAGGGAPVVIAVPAHWGPSTVDALRGALRNKPALSPGGVPPGLVPDSLTAMAALQADPGLPADGVVVLCDFGGSGTSVTLADASADFATIGPTVRYPEFSGDQVDQALLSHVLSGVAAAGDADPAGTAAVGSLNRLRAECRQAKERLSAETATAIPTDLPGFNSDVRITRPELEQLMSAPLVGLLDVIEDTLQRNNIALSSVNAVATVGGGAAIPLVTQRLSERLRAPVVTTPRPQLDVAVGAALVAERVVDAGAPTGMAPEVAAADAPTGMAPTSLGPAAWAAGATVAQPSANDADAGALAWSQDDAPGNEPVPYAGGEYETAGGATGARPPVAFSHEEEMYDAEPAPLAWYKRPPILFGAAAAAALLAAGGLAVTLTSSDGDSGPVTETSTTYSMGPSPEGPPPEPITTVTQGPDGIETTTVIAPPPPPPETTTSAPETTTTTSPTTTTTTTTTSTTTTTTTQPTTTTTTRTTTQPPTTTTAPPTTNPPTTSQAPITTSAAAEAPDGEA
>NZ_AP022565.1|WP_163665279.1|3142062_3142611_-|hypothetical-protein
MANTLLDFVMSLVRDPEAAAHYAADPAQAIADAHLTDVTSADVNNLIPVVSESLSTAGTSGVFGDPGVADPGGNVWASGAATAAFDAFGDHLPVDAPNHAWDAAASQVIDQADSLDQVVSSVPTIDDGGLVNQSLDEVSLQLNEPAIEDAPIFDQAPAPDWAHPVVDDQQHTDSGAGFDIFD
>NZ_AP022565.1|WP_163665277.1|3140646_3141777_-|hypothetical-protein
MAISLIDFILDLFRSPASAASFITDPDGSLRDAGLPNVTAAQLHAVAATAAPAGVLLGGGNPVLGLQRAVADHHSIPGQFASQVASPFSPQTQFAPEVASRNNTDFASHNDTDFASNNHTPIMSPNQDAGANAQQGAFNLGFGDITLGDKSTNTATNGGVVVDGENKGDIVSGDGAVLGDGNTMNNGDILAGSGSHVAVGKDNAIEDNSQHAGGDVVSGNDGPVIKDVDMSGGHGGGASGGDSLIGIGSGGASGGDGGNAGSIILTDASTHAVGGNQTTVDGDYGSRNTQDNSTHTSVQTETTHSVEDNSSSYTSNIGSGNDTAFASNNDTASHNDTSFGSHNDTSSALGSGNSYESQSHTDVASHNPIETGLDVF
>NZ_AP022565.1|WP_163665275.1|3138687_3140550_-|dynamin-family-protein
MTQPNDTRAGGPARPVKVIVELIDHTSTIAATYDRGDLVERLRVAKERISDPQIRVVIAGQLKQGKSQLLNSLLNIPVARVGDDESTVLATVVSYGEQPSARLVVARPDGAEPELVDIPPSEVTNDLRRAPQAGGREVLRVEVTAPSPLLKGGLAFVDTPGVGGLGQPHLSATLGLLPDADALLMVSDTSQEFTEPEMTFIRQAIEICPLATIVATKTDLYPHWREIVGANTAHLQRAGITTPVTPVSSVLRSHAIQLNDKELNEESNFPAIVKFLSDRVLTRESDRIRDQVVAEIHSAAEHLILTVNSELSAFTDPGERQRLTAELERRKQEAQDALQHTALWQQVLNDGISDLTADVDHDLRNRFRNITAHAEKEIDTGDPTLHWAEIGSELEEAVATAVGDNFVWAYQRAEALAAEVARTFTEAGLEAVQLPQIDARDMGAGFGEMKSLARLEAKPIKAGHKVITGMRGSYGGVLMFGMLTSFAGLGMFNPLSLGAGLVLGRKAYKEDMENRMLRVRSEAKTNMRKFIDDVAFVVGKESRDRLKGIQRQLRDHYRGIANQTTRSLNESLQATLAAAKVEETERNARVRELERQQNILTQVIDHAQRLAVEAPLGSNS
>NZ_AP022565.1|WP_163665273.1|3137154_3138645_-|dynamin-family-protein
MSTADQVRSILGGTIKAYRGDPAYRNRPDVHNELDRIGRRLNQPIRIALAGTLKAGKSTLVNALVGEDIAPTDATEATRIVTWFRHGPTPKVTANYRGGRRGNVPIARDPHDRGLTFSFAGLNPEDVVDLDVEWPAAELIDTTIIDTPGTSSLSRDVSQRTHRLLVPEDGVPRVDAVVFLLRTLNAADIALLKQIGELVGGSSGALGVIGVASRADEIGAGRIDAMMSAKDVAKRFTEEMDKTGICQAVVPVSGLLALTARTLRQSEFVALQKLAGIEPAQLTKAMLSVDRFVREDNSLPVDAATRAALLDRFGMFGIRISIAVMHAGVSDSVALADELLERSGLIALRDVIDQQFAQRSELLKAHTALLSLRQFVQRNPIYATPYILADIDPLLADTHAFEELRLLSLLRSRPTTLNEDEMASLRRIIGGSGTDAASRLGLQPDAPFDGPRSAFAAAQRWRRRADHPLNDPFTTRACRAAVRSAEALVAEYSSRH
>NZ_AP022565.1|WP_163665271.1|3135333_3137124_-|Hsp70-family-protein
MRDCLGLSVGATNLVAIADHTPLMRRAVLTDGLVFTDFVGRVGDPVPLVAADGSTHRAEQLLAGAVEALTREASPAHRPDVSVLAVPAHWNAGAVQAVRGALPGVRIVPDSVAALTAIQSYPGLPARGVVALCDFGGSGTSLTLADASAGFATIGETVRYLDFSGDLIDQELLRGVLNALDAEPAGTAAVAALTQLREQCRDAKEQLSSRAAASVAGAGGAIRITRAELEAVVDQPLGGVIEAMLDLLRRNGIHPARLAAVVTVGGGARIPLVTQRLSSTFRLPVTTVPQAQVIAAVGAGLLARRGVDETATQVAVAPPVSTPGFGTATVAASALAWSAEDSVAEVAEFVPESVTDDSARPEFVFSEPPLVSAPVRLAWYRRGGVVAYAAVFLAVVGTVGMVLSARADRLDAAVEGLSAPQTVPAESPLVQAVPAPPTRTVVVRDPSWPGPAAAAPAQAAAPQPAAAPRLVQSGQSAPLAPAPRQAAPAPQAPRPRPAAPAPAPLPAPAPVGLPPIPVPPLVFPPVTLPQLPIPTFKPPAPSPTPTPSPTATPEPTATPSPSPSPSPTATPEPTQTPEPTVEPTQTPTPTSVAPSP
>NZ_AP022565.1|WP_163665269.1|3134334_3135270_+|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein
MDVDDVLRQQDGVISRRQALDAGLPEHAIRRLLRRNQWARVHAGVYVNHTGPLTWPQRTWAAVLYAAPSALCFESALGAETSPIHLAVVQHRAILAEPAGVRIHHLVNLEERVLWNVSPPRMRYDEATLDVACRAASELDAIAILANACQSRRTTAQRLLHVLDSRTRVRRRRWLRAVLVDIADGTYSVLEHGYLTRVERPHGLPRATRQKRATSSVGICYRDAEYGEQLIVELDGRMYHDSATSRDADFERDLDAAVDGRSTVRLSYGQVFDRPCQTASKIAQVLQRHEIAVTGHPCGPECEFTRLDRAA
>NZ_AP022565.1|WP_163665267.1|3127753_3133231_-|PE-family-protein
MEGTTGSEAAAEEVVAAARELLTQRGIPVVGWEFDAIARPERDPAPVQRSRPNGDSTRVGSAPRFAAAVERYRPLGTVRPEKPAAHVDSSPGQVASLPVPVDAGPRGSSAQTAAVSVAEPVSPATAAAPPVVQQLLRIVGLAPALGSGSTPPAGAPLAWVMLGFVRRETDSRAAVEAMVLRANTDGSRQIAITDSLGGLAAQSRGVAALGAALDSQRPAMGRGGWLIGDGIDAAADCVADACNGGDGGWLMGNGGSGANGGHGGDAGMIGRGGVGGAATAAGQIGGNGGNGGLLLGAGGAGGSGGLYGVGGRGGDAGIFWGNGGRGGDGTSGGNGGNAAFTIGSGGRGGDALAAGQQGGDGGHAGWLLGNGGAGGKGGTGSAGTTGSSGSAGALGQDGGDGGAGTAGGAGGNGGTGGRGALFGKGGVGGAGGDGGTGGDGGTGGLGGAGTADGGTGGNGGNGGVGADGGTGGNGGAGGRGGLFGSTARAGVGGAGGVGGDAGTAGDGGAGAEAITPGRSGGAGGDGGDPGQVGSGGTGGIGWIRGADGAQGSLPTNGGNGGRGGDGADADVLGSAGGAGGRGGDAGLIGRGGDGGTGGNGADGGNGADAHGVDADGNGLTGGSGVTGGAGGVGGAGGAGGALAGNGGAGGDGGSGGRGGVGGQGSDGADGTFVAGAIGDGGRGGDGGAGGTGGVGGDGGTGGAAQAGGVWSAGVTGDGGDGGAGGNSGVAGNGGNGADAIVAGGTGGAGGDGGDPGLVGAGGAGGIGSNPGGTGAAGMLPTYGGDGGDGGNGLAGTAGADGGAGGRGGDGGRLGNGGDGGDGADGGAGGQGTAGADGVYVLSGGDGTGGIGGTGETGGAGGVGGAGGNGGDLAGDGGVGGAGGNGGIGGIGGTGGRGADGVVLVVYDGGDGGDGGAGGTGGIGGNGGAGGLAHSDLGVDGSQGIGGDGGSGGAAGIAGDGGTGAHGSTFGSSGSTGGDGGDPGAAGTGGVRGTGSTDGQDGASGAQATTGGNGGNGGNGSTGSIFGPFGPGGNGGNGGNGGLVGNGGDGGDGADGSSGGGLIGPNGYNGGNGGNGGLGGAQAGNGGNGGNGGDAGNGAAGTNGSHGANGTGDDGTDGTNGGNGGTGGKGGNGGLAQSSTGSQGAGGNGGDGGDAGRAGDGGNGGDGGVVKVSGGKGGNGANPGTAGTGGVGGTGSTDGTDGTDGSSAGGGKGGVGGNGANATTNGANGGAGGNGGNGGIVGNGGAGGNGGHGMVGSAGAAGTFAGGGDGNGANGTAGGNGGNGGAGGSGGSDAGVGGTGGNGGNGAVGGTGGAGAAGDGPGASGGNGGNAGNGGSGGSGGAGGATQHSGGTGGKGGNGGNGAVGGSGGKGGNGADGAIVPGGTDDQALGGAGGDGGNGGNNGIGGGAGLGGAGTTPGASGGFGNTPTGSGGNGGDGGDGGDGFQFWGGATGGAAGNGGNGGNYGDGGNGGHGGDGGNGRGGGIGIDGESGANGGAGGAGGTGGAFGGTGGTGGTGGDGGDGGNGVDGTTSLNADGSNGGSGGAGGVGGAGGSAGSIYGSAGNGGAGGDGGSAGNGGNGADALQYQSGGNGGNGGSAGAAGAGGAGGTASFPGGNGSNGAAGTYLDGGTGGKGGNGGNGSDGQTTGSQTSAGAAGKGGNGGNGFNGGDAGNGGNGGSGWNATNGGAGGNGGRGTGGAGGDGGDGGKGGTGSNVSQIIVVIHDAKPGGAGGAGGHGGDSIGGTGGGKAGQGGQGGNGGNGNPGLFGAPSAVGGHGGKGGNGGWYYPAGIGLVKQGATGQNGGSQVDRTPPLGGLGGAGGAGGAGGAP
>NZ_AP022565.1|WP_163665265.1|3127255_3127744_+|hypothetical-protein
MSNYYEDNDEPTQYAPSYGEYSDAPAPPTPEPIPWYRKPAALLGLGAVGALIAALVIYALVQLFSSDSPSDSSTLTTTTSTTPTTTTSVVTSAPVVPAPTHTVTETVAPTTTTVEEAPVTTTTTTTAPPTTTTETTTTTTEPPTTTTTAPVTTTQPPAGQNP
>NZ_AP022565.1|WP_163665286.1|3150193_3150415_-|hypothetical-protein
MARINTLAAAIGGSAVVAMGILALTLGGPHESPTAIAYGGSMTIGQTTTVTYTGTVSPASAAPAVKAPPYGKH
>NZ_AP022565.1|WP_163665288.1|3150621_3151911_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MDGGETMVNVTTHQLPWQTGQHPKPRTFAQSTKLQDVLYEIRGPVHEHASRLEAEGHRILKLNIGNPAPFGFEAPDVIMRDMIQALPYAQGYSDSKGIASARRAVFTRYELVEGFPKFDIEDVYLGNGVSELITMTLQALLDNGDQVLIPAPDYPLWTASTALAGGTPVHYMCDETQGWNPDVADIESKITERTKALVVINPNNPTGAVYSRETLEQIVELARKHQLMLLADEIYDKILYDDAKHISLATLAPDLLTLTFNGLSKAYRVAGYRSGWLVITGPKEHASSFIEGISLLSNMRLCPNVPAQHAIQVALGGHQSIDDLVLPGGRLLEQRDMAWNKLNEIPGVSCVKPAGALYAFPRLDPEVHDIHDDEQLVLDLLLQEKILLTQGTGFNWPTPDHLRIVTLPWARDLAQAIERLGNFLAGYRQ
>NZ_AP022565.1|WP_163665290.1|3151951_3153181_+|YibE/F-family-protein
MAHSHSHSHSLAGSSPLSPLAARIVVGLLVAIGVAMLIGAAMLWPSHQKVDIPLPFQNAAGGAVTTEAGHVTSSTLADCGSPSAGGVLTAAPKPAEPGGGTCVQNLVAIDSGPNAGAKTLLEFTTGPGQPNLAAGDSIRVSRQVDQAGTTSYAFFDFERTWPLVALAVVFAVVIVAVARWRGLRAIVGIVVAFAVLMIFLLPALRDGAPAVPVSLVASAAILYAVIYLAHGVSLRTSAALLGTLTSLLLAAILSWAAIELAHLTGLSEDQNNEVAAYMGNVSITGLLLAGFIIGSLGVLNDVTITQASAVFELAEHGGSRRAIFAGAMRVGSDHIASTVYTLVLAYAGSALPLLLLFSVANRSLGDVLTGESVAIEIARSAVGGIALALSVPLTTGIAAVLATPTTGTK
>NZ_AP022565.1|WP_163665292.1|3153189_3153558_-|nuclear-transport-factor-2-family-protein
MTTSEIATVLAWHDALNEDDVETLIALSSDDIEVGDANGAAQGHAALRNWAESGGDTVTPGRMFVHDGVVVVEQTIMAGDGSTRTGAAAFRVVHDHVTSAFRHDTLAAALAATELTEKDLVG
>NZ_AP022565.1|WP_163665294.1|3153576_3154329_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MDFRAALLDQTRSFGELIASSDPETPVPTCPDWTLKQLFRHVGRGNRWAAQIISERRVSPLDPREVHEGKPPDDPDAAIEWLNAGAAQVLKSADQIGTDARVWTFLGPKPEGWWIRRRVHEVAVHHIDAALAVGSEFVLPADLAADAVSEWLAIATGMANKRHHEPLAFGSSIHLHATDDGLGPTGEWTIEHDEDGLGWSHSHGKGTVALKGPAQKLLMAVTRRGTAADLGLEVFGDTATWDTWLDRTPF
>NZ_AP022565.1|WP_170309401.1|3154330_3155647_-|cytochrome-P450
MRERIRWMALHGVVRGISAYGVRRGDPQARLIADPAVRADPAPFADEMRRRGPIVRGRAILMTFHHDVATDLLRSDDFRVSRLGGNLPRPLRWVADKTDTGMLHPLLPPSLLAVEPPDHTRYRKLVSSVFTTRAVARLRERVKETADELLDSMDGDAGVVNIVDRYCAQLPVAVISDILGVPDADRSQVLRFGELGAPSLDIGLSWQQYQQVNSGIHGFETWLTHHLRQLRRNPGDDLLSQIIAASEAGAAGEPLDEAELRALAGLVLAAGFETTVNLLGNGIRMLLDHPEHLQTLSARPELWPNTVEEILRLDSPVLMSARVALRDTEVAGTAVQAGELVIVHLAGANRDPAVFTDPHRFDIERDNAGRHLSFSGGRHFCLGAALARAEGQVGLQTFFDRFPDVRAAGEGNRRDTRILRGWSSLPITLEKARTAVGS
>NZ_AP022565.1|WP_163665295.1|3155685_3157017_-|nucleotide-sugar-dehydrogenase
MRCTVFGTGYLGATHAAGMAELGHEVIGVDIDPGKVAKLAAGDIPFYEPGLRKVLNDNLSAGRLRFTTDYDEAADFADVHFLGVGTPQKKGDYGADLRHVHAVIDTLVPRLRRSAVIVGKSTVPVGTAGDLAERARGLAPADVDVEVAWNPEFLREGYAVHDTLHPDRIVLGVQHDSTRAEAAVRELYAPLIDDGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVTLLADALGYDPRIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGANHALTFLREVDSINMRRRTAMVELTTRACGGSLLGANIAVLGAAFKPESDDVRDSPALNVAGMLQLNGAAVNVYDPKAMDNSQRVFPTLNYSTSVVEACDRADAVLVLTEWAEFVDLNPAELADTVRVKVVVDGRNCLDAQRWREAGWRVYALGRPVATV
>NZ_AP022565.1|WP_163665296.1|3157093_3158623_-|hypothetical-protein
MDIVLGVAMAPTTVRMVLVEGEKADGVTVDHDVFDVTAGDDSATTSASDQVVAAILGTQESATAGGHHLKSIGVTWTDHSDAAALRDTLSAHGIDDVMLVSEGHAAAALAQAVGRAVGYDTTALLFIDRDTATLSVVKTDDGSVVKVLAQSLHSADAMAVLTDMAAAVEASDSAPDGMFVLGAGVDVASVKAHLENLVSLPVSAPDEPEMALARGAALASAHAPAFEATTVGLAYSQDPDGSTAGSAYALAGLATEMAPLGDAPVDGVELVGDEMPMEEERKPFLLVGSALTSVFVVGVVALVISLAVNIRPTVDQRPAPAQGAVAPSAPAKLPAPAPPPAALVPPPPAPPPETIKAPIPVVQEAPAPAPQAPPRTVYVEQPAAVPPPAPEAPAPAPVPEAPVPAPPPIAPPPAPYIPPLVVLPPAPRLPNIFRPQWDPPQRQWDPPRRQWDPPSRHEREAPQWPGQGSDDWNPGRSGRGSDDWNPGRSGGSHRGGDGGTLWPFPFGGH
>NZ_AP022565.1|WP_163665297.1|3158843_3160175_-|ammonium-transporter
MPEIDPAATAWLLASTALVLLMTPGLAIFYGGMVRTTGVLNMIMMSFISIPLVTVAWLLVGYTLAFSEDAGGGLIGGLQHFGMLGITPGTVHGAVPELLFATFQLTFAIITAALVSGAIADRAKFAAWMLFVPVWAVAVYAVVAHWVWGPGGWLAGLGVLDYAGGLVVEIVSGSSALALALVLGPRIGFKQDAMRPHNLPFVLLGVGLLWFGWFGFNAGSAMAANGTAAAIFLNTLVAGCLGMLGWLTVEQVRDGKPTTFGAASGVVAGLVAITPSCGTVNTLGAVVVGLAAGVVCSFAIGLKFRFGYDDSLDVVGVHFVGGVVGVLLIGFLATEVMTQGPQGLFYGGGLTQLGKQLLGAIVVAAYAFTMSYLLAKAIDRFMGFRLSPEDETTGVDFTQHAESAYAEGVHGHLPQRRPGLFGQLGQPGGLMPRPDPAEEDSAG
>NZ_AP022565.1|WP_163665298.1|3160369_3160942_-|dCTP-deaminase
MLLSDRDIRAEIAAKRLAIEPFDDTLVQPSSVDVRLDTLFRVFNNTRYTHIDPAKQQDELTTLVEPAEGEPFVLHPGEFVLGSTLEVCTLPDDLAGRLEGKSSLGRLGLLTHSTAGFIDPGFSGHITLELSNVANLPITLWPGMKIGQLCLLRLTSPAEHPYGSDKVGSKYQGQRGPTPSRSHLNFIKSS

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Crispr_ID: NZ_AP022565_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022565_3

3579510-3579646

Orphan

Consensus_repeat	Method
CGTCTCCGGACGAAACCTCCGCAACATCACCACCACCTTCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022565_3

>merge|NZ_AP022565|3|3579510-3579646|CRISPRCasFinder
CGTCTCCGGACGAAACCTCCGCAACATCACCACCACCTTCAACACCTCCGGCATCAACAACTGCATCCCGTTCCGACGCTGACTCAGCGGCGGCACCGTCTCCGGACGAAACCTCCGCAACATCACCACCACCTTCA

>NZ_AP022565|3|3|3579510-3579646|CRISPRCasFinder
CGTCTCCGGACGAAACCTCCGCAACATCACCACCACCTTCA	ACACCTCCGGCATCAACAACTGCATCCCGTTCCGACGCTGACTCAGCGGCGGCAC
CGTCTCCGGACGAAACCTCCGCAACATCACCACCACCTTCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022565.1\|WP_163665922.1\|3570658_3572008_+\|type-VII-secretion-associated-serine-protease-mycosin	unknown	unknown	gnl\|CDD\|274856
NZ_AP022565.1\|WP_163665949.1\|3589340_3589634_-\|PE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376422
NZ_AP022565.1\|WP_163665926.1\|3573451_3573790_+\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|376829
NZ_AP022565.1\|WP_163665945.1\|3587567_3587870_-\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|377587
NZ_AP022565.1\|WP_163665935.1\|3581634_3582189_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022565.1\|WP_163665939.1\|3584163_3585696_-\|type-VII-secretion-integral-membrane-protein-EccD	unknown	unknown	gnl\|CDD\|274855
NZ_AP022565.1\|WP_163665930.1\|3574707_3575955_+\|IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NZ_AP022565.1\|WP_163665924.1\|3572004_3573402_+\|type-VII-secretion-protein-EccE	unknown	unknown	gnl\|CDD\|274857
NZ_AP022565.1\|WP_163665920.1\|3569697_3570285_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022565.1\|WP_163670071.1\|3577995_3578787_-\|secretion-protein-EccK	unknown	unknown	unknown
NZ_AP022565.1\|WP_163665933.1\|3580400_3581363_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022565.1\|WP_163665947.1\|3587964_3589299_-\|PPE-domain-containing-protein	unknown	unknown	gnl\|CDD\|366325
NZ_AP022565.1\|WP_163665928.1\|3573816_3574563_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022565.1\|WP_163665951.1\|3589814_3591566_-\|type-VII-secretion-protein-EccCb	unknown	unknown	gnl\|CDD\|274859
NZ_AP022565.1\|WP_163665943.1\|3587249_3587537_-\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|227179
NZ_AP022565.1\|WP_163665932.1\|3576220_3577723_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376051
NZ_AP022565.1\|WP_163665918.1\|3569325_3569646_+\|ESX-1-secretion-associated-protein	unknown	unknown	gnl\|CDD\|371259
NZ_AP022565.1\|WP_163665917.1\|3568442_3569333_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022565.1\|WP_163665937.1\|3582870_3584007_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|197548
NZ_AP022565.1\|WP_163665941.1\|3585692_3587120_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|223531

Protein	Function_ID	Function_description	E-value
NZ_AP022565.1\|WP_163665922.1\|3570658_3572008_+\|type-VII-secretion-associated-serine-protease-mycosin	gnl\|CDD\|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	3.87673e-129
NZ_AP022565.1\|WP_163665949.1\|3589340_3589634_-\|PE-domain-containing-protein	gnl\|CDD\|376422	pfam00934, PE, PE family. This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	0.00143384
NZ_AP022565.1\|WP_163665926.1\|3573451_3573790_+\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|376829	pfam02575, YbaB_DNA_bd, YbaB/EbfC DNA-binding family. This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure. The conformation of the DNA is changed when bound to these proteins. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage.	8.9191e-07
NZ_AP022565.1\|WP_163665945.1\|3587567_3587870_-\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|377587	pfam06013, WXG100, Proteins of 100 residues with WXG. ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.	1.41479e-07
NZ_AP022565.1\|WP_163665947.1\|3587964_3589299_-\|PPE-domain-containing-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	3.87327e-43
NZ_AP022565.1\|WP_163665930.1\|3574707_3575955_+\|IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	0
NZ_AP022565.1\|WP_163665924.1\|3572004_3573402_+\|type-VII-secretion-protein-EccE	gnl\|CDD\|274857	TIGR03923, T7SS_EccE, type VII secretion protein EccE. This model represents the transmembrane protein EccB of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccE1, EccE2, etc. This model represents a conserved core region, and many members have 200 or more additional C-terminal residues. [Protein fate, Protein and peptide secretion and trafficking].	5.35804e-81
NZ_AP022565.1\|WP_163665939.1\|3584163_3585696_-\|type-VII-secretion-integral-membrane-protein-EccD	gnl\|CDD\|274855	TIGR03920, T7SS_EccD, type VII secretion integral membrane protein EccD. Members of this family are EccD, a component of actinobacterial type VII secretion systems (T7SS) with ten to eleven predicted transmembrane helix regions. [Protein fate, Protein and peptide secretion and trafficking].	4.05022e-91
NZ_AP022565.1\|WP_163665951.1\|3589814_3591566_-\|type-VII-secretion-protein-EccCb	gnl\|CDD\|274859	TIGR03925, T7SS_EccC_b, type VII secretion protein EccCb. This model represents the C-terminal domain or EccCb subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	0
NZ_AP022565.1\|WP_163665943.1\|3587249_3587537_-\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|227179	COG4842, COG4842, Uncharacterized protein conserved in bacteria [Function unknown].	1.93993e-16
NZ_AP022565.1\|WP_163665932.1\|3576220_3577723_-\|hypothetical-protein	gnl\|CDD\|376051	pfam18625, EspB_PE, ESX-1 secreted protein B PE domain. The ESX-1 secretion system is an important virulence determinant in Mycobacterium tuberculosis. ESX-1 secreted protein B (EspB) contains putative PE (Pro-Glu) and PPE (Pro-Pro-Glu) domains, and a C-terminal domain, which is processed by MycP1 protease during secretion. This domain represents the PE domain located at the N-terminal region of EspB which carries the conserved YxxxD/E secretion motif.	1.98417e-12
NZ_AP022565.1\|WP_163665918.1\|3569325_3569646_+\|ESX-1-secretion-associated-protein	gnl\|CDD\|371259	pfam10824, T7SS_ESX_EspC, Excreted virulence factor EspC, type VII ESX diderm. T7SS_ESX-EspC is a family of exported virulence proteins from largely Acinetobacteria and a few Fimicutes, Gram-positive bacteria. It is exported in conjunction with EspA as an interacting pair.ED F8ADQ6.1/227-313; F8ADQ6.1/227-313;.	7.11613e-14
NZ_AP022565.1\|WP_163665937.1\|3582870_3584007_-\|hypothetical-protein	gnl\|CDD\|197548	smart00157, PRP, Major prion protein. The prion protein is a major component of scrapie-associated fibrils in Creutzfeldt-Jakob disease, kuru, Gerstmann-Straussler syndrome and bovine spongiform encephalopathy.	0.00406701
NZ_AP022565.1\|WP_163665941.1\|3585692_3587120_-\|AAA-family-ATPase	gnl\|CDD\|223531	COG0455, flhG, Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility].	1.18455e-53

>NZ_AP022565.1|WP_163670071.1|3577995_3578787_-|secretion-protein-EccK
MSAARAERDAAQNAAKRSSDPLVLARRIAAALNAPDMLNIEDYDFYWITALTAEGQIVVANNYGLAYLPAQVRLPEDVKLVSADESIPANERASFATYPMVAVQRWAQHHDTTLRAVIGGEEHLAKSDAGAHKVVLTPDDIPAKGQMAGRDRLQVIAPQIAMRLAGFSDADLINILPPASADTSPPEDRRTTLWEEVWEPLCSSAYDRGQVHLQAFLTYAIHAQEWAVYEAHAATDGPDQRRAAADFIYWQHVGQLIADALDA
>NZ_AP022565.1|WP_163665932.1|3576220_3577723_-|hypothetical-protein
MKKKAADITADRADKSPVPLPAPPDALQITTAATNQLNASSTRLEQTFSAADTEAGRMASALRAAADAFDEVVSTSKEEFDKSMNSDGARPSQRFETVVPSGVMDAAPATVQVPYPAAAQTGAYAKWRETAKELDGTNTSGLEEFRDAWKRTKGWLDKHKDKFIAPKGDGTAADAYTEAMERLREWWEHMGPEAERMIEQAQNFIDAHRDLVNEHPTMDDVATYERLSPGGVVGVLVGLSPAAMLGKGALNAHFQERSDAALKKYADKVAFHEIRPGMPPSIRGVASTTPDGPPPGGNPQIGGPSAPTTSGGDPSIPEMPSMPEMPSMSPASAEPSAGQGSGGSPSGGGSPSGGSPSGGGAPSGGMPSGLPKGTEGMPEMPGVGEPSLKPASAGGGGGMGGGGGGMPSMPLGPAVGADSVGPSPAAARGGGGVPGSPGGGGMGGMGGGMGGMGGGHGQNQGKEKRRNPNLSEDEDLYKEDRAYTEAVIGRRARKDPKDGK
>NZ_AP022565.1|WP_163665930.1|3574707_3575955_+|IS256-family-transposase
MTSSEPIDLEQLLSDQLAQASPDLLRGLLSAFIHALMGAEADAICGAGYRQRSDERSNSRNGYRHRDFDTRAGTLDVAIPKLRQGSYFPDWLLERRKRAERALTSVVATCYLLGVSTRRMERLVESLGVTRLSKSQVSVMAAELDEAVEAFRTRPLDAGPYTFVAADALVLKVRENGRVVGVHTLIATGVNAEGYREILGIQVTSAEDGAGWLAFFRDLVARGLSGVALVTSDAHQGLVAAIGATLPGAAWQRCRTHYAVNLMAVTPKSSWPWVRTLLHSIYDQPDAESVHAQYDRVLDALSDKLPKVAEHLDAARADLLAFTVFPKQIWRQIWSNNPQERLNREVRRRTDVVGIFPDRTSIIRLVGAVLAEQHDEWIEGRRYLGLDVLTRARTSLTDTEEPTDQQTNTTPALTA
>NZ_AP022565.1|WP_163665928.1|3573816_3574563_+|hypothetical-protein
MGNFSRRFGIALNLILALVCGIWAFIAIKHLNFITAVIAVGLITTCLLVAIQLVVSKNAVVQAAFDESGMLLRPDSRLESTQRRSNLALALSGLSMFIAWTTGWLYLPLPDGVGQVFPIAFGATGLVAGWFWFVFKRQGGTSYLLLTPEEFEFPNLGSLNSGKWDDITAVTDQLPTEGRFWTPMGITMKDGSRLVMDSPGSYTRKGTALIELVRFYWRHPEQRSEFTDGHALDRLRALDPQHSPGTKS
>NZ_AP022565.1|WP_163665926.1|3573451_3573790_+|YbaB/EbfC-family-nucleoid-associated-protein
MTEEMHPQVAAVLRQAQQLQSLMDDQLHKMNTETFTAADEARSVEVTLNGHHHLIDVYIKDGLLRLGAQAVEQRLNEAIQKATAAATSSIEADRERLDAMVAELTAEGQQLG
>NZ_AP022565.1|WP_163665924.1|3572004_3573402_+|type-VII-secretion-protein-EccE
MNFLQRHFGFRFTTGHAIWAATLIPACLAICLHFHLLWLGITLSVLIAIFSVLTIRGYRLTGWVRAIFSWRRRHRSTPDVPSEPAVGATVMPGDHVAVRWQGDYLVAVIELVPRPFTPTVIVNGGAVSDDTVSTKLVEKLLAAHCPDLEADIVSAGYRVGKIAPASLVALYEQVVGPYPAPANRRTWIVLRAKPEETRRSAQRRDSGVSGLARYLVASATRIADQLASNGIDAQCSRSFDDYDKATEISFEKETWSLIKGRSTFTAAYNAPGGPDVWWSARADHTTTCVRVRPGTAPTTTVLLTTLSTPTTPRGFSCLYGGQRAALQGLTPVTDKHHELPIGSAGVLVGETSDRYPVYMPFDNVDVSINLGDARLFTQFVIRSAASGAVVTLGPQFREFATMINGRVGRVPRVAWPNSTTYLGPHQGVGRVIMRPNFIDTPRHRQLPITLINPREESRYQMALEQ
>NZ_AP022565.1|WP_163665922.1|3570658_3572008_+|type-VII-secretion-associated-serine-protease-mycosin
MQRLVVMLLAVLLALFSAPPAFAIDPPAIDAAAVPPDETGPDQPTEQRKICAAPTVMPNSNFADKPWAADYLRLADAQKFATGAGVTVAVIDTGVNGSPRVPAEPGGDFVDAAGNGMSDCDAHGTLTASIIAGRGSPTDGFIGVAPDARLLSLRQTSVAFQPKGSRQDPNDPNTTQTAGSIRSLARSVVHAANLGAQVINISEAACYKVTRRIDESSLGAAINYAVNVKGAVIVVAAGNTGQDCTQNPPPDPSVPADARGWKGVQTIVSPAWYDPLVLTVGSISQNGQPSNFSMSGPWVGAAAPGENLTALGYEGQPINATPGEDGPVPLNGTSFSAAYVSGLAALVKQRFPDLTPAQVINRITATARHPGGGVDNYVGAGVVDPVAALTWEIPEGPEKAPFRVKEVPPPVYIPPPDRGPITGVVVAGAALALILGIAAMTRRALRRRQ
>NZ_AP022565.1|WP_163665920.1|3569697_3570285_+|hypothetical-protein
MTPRGSDDWDDTDDDGLDALDLGTPLFTDDVSGLDALPDYAGGDADQDGAHDSGLDAVHDYTGHEVDKVVDDSFGAFDTEAEPEDQERIPVVQAINPPGTVTVTAYLNGSVAQVDLDPKVTALTEAQLADEVRFVAGVAAKRATAVMHIGVVNMLIAQGMALPEARDFVATNMPYATPEQAGEAELALIARHSDH
>NZ_AP022565.1|WP_163665918.1|3569325_3569646_+|ESX-1-secretion-associated-protein
MSDGTLGVTSSHVRELSDGQKMAQQLIELNSEVTGGVSASMLVNHGPICAVSITALEFANNAREAACAAMASVSQDMSEKLNISAAQYDQTDTQAGADIGKQMHPR
>NZ_AP022565.1|WP_163665917.1|3568442_3569333_+|hypothetical-protein
MGTLEHAKQVIEIGFAGKGFGEHLFAANSDDPQAASLAKIGFVADGIGAGQMLGEFGANKLFGVTPTSFSSYSSPAKTINGFGTPIIGAALLAINGMQLMCGVGDPETGDRFAKGAHHFTAIADTLKWSTPTEQWHGRGSDAYAAENEQQQERAAKMSKIDAEVKGIVANEAKQISNTRTALEIVATSLTFMIPIAIAIGKIPPTGPANQMAFEIGAVAGSMPIALGAFGTMESLTLANAQKFRQAASDYQEVAAGAKPAGAPPASVSPPGGSTTSKPWSPSGGSATGTGEGSINV
>NZ_AP022565.1|WP_163665933.1|3580400_3581363_-|hypothetical-protein
MGLALVAIIAVSIVGTVLVLRPDSGGGQAGTDNGGSEFASANDTGPANIITEDPTCEAWGKISDQITAVSKSVNWNSQDYSVPAAEWSTEQRAAFEKESAALSDAIPNVSSIAKQTPHRVVRELYGQFNAYAQALVDAVPSYSSADHYTAVASNKFFGVLNRLCDSIHFRAAQQTAPLVASTEPPSNSSSPRDDGAAVPEIFLSRNNGACSDWIAMVQRFDADTKEWRELNPNVRPPEWTPERKAIMDAATPVLVTYADDMERLGRGSGNAIWEDFAVFAAQYLRAYVKGIPTYTPNYVYMSLTSNTLSNAILWACKAQS
>NZ_AP022565.1|WP_163665935.1|3581634_3582189_-|hypothetical-protein
MAADRYEKTDQQAHSDVSDRLAEFDSKFGSSSSNGGGATDAMGQFGQMMQMPMQMAQQLGQIPMQIAQQAGQIPQTIMQGVQQFAQMGGGLGQDGAGADGGSGTDTAGAGPDAVQQTSADGEDREEPGEREDQEEKPDGAAASDGGEQRAPVAEAPVEAAPADPPLEAVPAQPKRPPVDPSVLL
>NZ_AP022565.1|WP_163665937.1|3582870_3584007_-|hypothetical-protein
MSFPPQGPYGSQPSDGGPPWGGPPPHYGQQPGGGPWSQRGWTGTPPPPNNGGKGKWILIGLALVAIIAVSIVGTVLVLRPDSGGGNGSSNTADGASAFASANDTGPANIITEDPTCEAWTKISRDVSAAVPEWNKQDYSVPATEWTPEQQRVFEKKSAALKSAIEKAGNLAKQTPHRVMRELYGQYNAYAQAVIDSIPNYSSDDNKTVAASNQFASSLNRVCDAIYFRAAQQTAPLISEAAPPSDPQVPNGDRNLVPERFLTSRHGRCEDWMTAVQRFEKDAKDWRDIDAKIPATEWTPDQMSVMDAVMPVMTAFANDIEQLGRQSGNPVWEDFAVLAAQSMRAYVQAIPTYTVNTGYMSSLSARLYSAINWACKAES
>NZ_AP022565.1|WP_163665939.1|3584163_3585696_-|type-VII-secretion-integral-membrane-protein-EccD
MTASTASADTSSAKPGRPSTTRVTILTGKRMTDLVLPAGAAIETYIDETVSVLGELLEDTPKDTLAGFDFSEQGMWAFARPGAPPLKADESLDDAGVVDGSLLTLVSVSRTERYRPLVEDVIDAIAVLDESPIFDRTALNRFVGVAIPVVATAITAMSLVSWNGSGQGWWWALALGLFGLGLLGGSFAAQSRYQNLDLAESLLLAATIVLAGAAALAVPLPYDADSLGAPQLAGAGAVVLLLTLATRGGPRRRADAAAFVAVLAIAVTAAATAVGYDGTPWVPAGAIAFGLIVVTNAAKLTVAVARIALPPIPAPGETVSNDELLDPVITPDEVDEASPTWKAIIASVPESAARLQERSLLTRQLLIGFLSAGSLVLSVGAIAVVVQGHFFVHSMIVAVLVAVICGFRSRLYAERWCSWALLAAAVAVPTGVMVRLCLWNPGSAWLVLAIYTALGLVAVIAVGATDGVRRVSPVTKRILELSDGLAIAAVIPLLLWIAGVYDLLRNLRLH
>NZ_AP022565.1|WP_163665941.1|3585692_3587120_-|AAA-family-ATPase
MSADYDRLFHSSEPGKPVDDATAIVDRDAILKAAAAATPPPVPVGETSSTSVPVAPTAPTQTQAAPQQPRHAETAPQMPAPMPAPPASAPQWPQNSMLRAPQQQMGQGARHEQPVAQPGPVARVAPGPAPSQFADLDPEVSGQWRAGQAIPSPAAPGPTSAASMGNHRAIDALSHVGVKTGVKMPSQRGWRHWLYLTTRINLGLSPDEIYELELHNRIRRNARDSYQIGVFGLKGGVGKTAVTVALGSAMAKVRGDRILAIDADPDGGNLADRAGRQSAATISDLLADQELSRYNDIRAYTSMNGANLEVLSSEDYSGAQREFNDDDWKGATAVVSRYYNLVLADCGAGLFQKASRGVLSTVSGMVIVASASIDGARQAAITMDWLRQNGYQDLLGRSCVVINHVTPGKVNVDVEDLVQQFERHVPPGRVIVLPWDKHIAAGTEIQLELLSETFQRRITELAAALSDDFDRLERR
>NZ_AP022565.1|WP_163665943.1|3587249_3587537_-|WXG100-family-type-VII-secretion-target
MTEQVWNFAGIEGGASEIHGAVSTTAGLLDEGKGSLATLASAWGGSGSDAYQAVQARWDNTSNELNTALQNLAQTISEAGQTMAQTEAGVSGMFA
>NZ_AP022565.1|WP_163665945.1|3587567_3587870_-|WXG100-family-type-VII-secretion-target
MAQMNTDAAVLAKEAANFERISGELKSVIAQVESTGGALAAQMQGQAGTAAQSALLRFQEAADKQIQELNDISTNIHTSGTQYTSTDDDQASTLSSAMNI
>NZ_AP022565.1|WP_163665947.1|3587964_3589299_-|PPE-domain-containing-protein
MVAAPPVPPTWFALPPEVNTARLMLGAGPAPMLQAATGWEGLAILLETQADELAGALNALTAVWSGTSSERAVSATLPMIMWLRTVAMQAQKRALQAGAQASSYTLALTTTPPIPEIEQNHITHGVLEATNFLGINTMPIGLNEMDYFVRMWNQAAGAMEAYHAETTINLLFEPIMPMTPIVLPGIGETTAAAALASTAPRTAQGLLRNAIIEGVSAKATIESVALNAGRTAAWVNHAEQRGVGAANKGENAARQEQNPTDKNPMQQGMQMVMQMGQQAGQLAGQIPQMLQSPMQMMTQPLQQVTQMVSQFAGMGGSDKGMQMGLMGAMPFSNHPLAGGAGPSSGAGLVRAASLPGALGSPPRTALLSSMLGISGEAKPASAGGAMGAAGPVAPVSSGAGGGGAPMTGAGHNDKKSSGGTKEGLISPTALTYDNDNSDDGDDDW
>NZ_AP022565.1|WP_163665949.1|3589340_3589634_-|PE-domain-containing-protein
MQPMMHNPGAEGVAAQVIANAARGLAGGTTASAAVTALVPAGADEVSAMAAMAFASEGVEALAANSFAQEELTRAGAAYAEIAGIYNAVDAAQATTL
>NZ_AP022565.1|WP_163665951.1|3589814_3591566_-|type-VII-secretion-protein-EccCb
MSTDAEPRVLREVVLGQLGTGESRAYKMWLPPLTDPTPVNELVERDHQRAPLRFALGIMDEPRRHRQDIWGVDVSAAGGNIAIGGAPQTGKSTFLQTLMLSAAATHTPRQVQFYCIDLGGGGLMYMEELPHVGGVATRAEPDRVNRVVAEVKAVLRAREQVFKQYRVGSISSYREMREDPNNPAAQDPFGDVFLVIDGWPAFVAEFPDLEPAVQDLAGQGLAYGVHVIISTPRWTELKSRVRDYLGTKIEFRLGDVNETQIDRITRDIPANRPGRAVSLEKHHLMMGVPRLDGVHSAANIVDAISAGVQEVASRYTDQAPQVRVLPEKIYLHQLDPNPPGPDSDYRTRWQVPLGVRESDLAVAYNQMNMTPHLLIFGAPKSGKTTIAQAVSKAICARNSPDQVRFMLADYRSGLLDAVPDTHLLAAGAINRNSASLEESIKALASNLKKRLPPPDLTTAQLRARSWWSGPDIVLLVDDWHMIVAAAGMMSPMAPLGPLLPAAADIGLHVIVTCQMSLAHRATMDKFVGAAYGAGSPTLFLSGEKNDFPSREIIVKKRPPGQAFMVSPEGKEVIQAAYVDPPEE

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Crispr_ID: NZ_AP022565_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022565_4

4638073-4638189

Orphan

Consensus_repeat	Method
GCCCTGGGGTGGAAAGCGGCGTGCGGGTGGGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022565_4

>merge|NZ_AP022565|4|4638073-4638189|CRISPRCasFinder
GCCCTGGGGTGGAAAGCGGCGTGCGGGTGGGATGTTCGTTTGCGCCATTTCCGACGCCGGGGTCGTTGCGCTGCGTGGTGTGCAGCCCTGGGGTGGAAAGCGGCGTGCGGGCGGGAT

>NZ_AP022565|4|4|4638073-4638189|CRISPRCasFinder
GCCCTGGGGTGGAAAGCGGCGTGCGGGTGGGAT	GTTCGTTTGCGCCATTTCCGACGCCGGGGTCGTTGCGCTGCGTGGTGTGCA
GCCCTGGGGTGGAAAGCGGCGTGCGGGCGGGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022565.1\|WP_163667666.1\|4635583_4636753_-\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|236095
NZ_AP022565.1\|WP_163667684.1\|4643051_4644041_+\|TIGR03560-family-F420-dependent-LLM-class-oxidoreductase	unknown	unknown	gnl\|CDD\|274648
NZ_AP022565.1\|WP_163667687.1\|4644021_4644729_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225222
NZ_AP022565.1\|WP_163667654.1\|4632159_4633242_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|224717
NZ_AP022565.1\|WP_163670246.1\|4646193_4646874_-\|LpqN/LpqT-family-lipoprotein	unknown	unknown	gnl\|CDD\|378485
NZ_AP022565.1\|WP_163667651.1\|4630474_4632142_-\|alpha-keto-acid-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|226470
NZ_AP022565.1\|WP_163667669.1\|4636876_4637983_+\|alkene-reductase	unknown	unknown	gnl\|CDD\|239243
NZ_AP022565.1\|WP_163667678.1\|4641979_4642567_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379312
NZ_AP022565.1\|WP_163667661.1\|4634193_4635069_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_AP022565.1\|WP_163667672.1\|4638334_4639546_+\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|236197
NZ_AP022565.1\|WP_163667663.1\|4635133_4635583_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176861
NZ_AP022565.1\|WP_163667648.1\|4630029_4630470_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176861
NZ_AP022565.1\|WP_163667675.1\|4639557_4641705_+\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|183293
NZ_AP022565.1\|WP_163667696.1\|4645824_4646148_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022565.1\|WP_163667693.1\|4645460_4645784_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022565.1\|WP_163667690.1\|4644820_4645279_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022565.1\|WP_163667642.1\|4627738_4628344_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|188483
NZ_AP022565.1\|WP_163667681.1\|4642571_4642997_-\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|274679
NZ_AP022565.1\|WP_163667657.1\|4633301_4634201_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_AP022565.1\|WP_163667645.1\|4628393_4629950_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224154

Protein	Function_ID	Function_description	E-value
NZ_AP022565.1\|WP_163667666.1\|4635583_4636753_-\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|236095	PRK07777, PRK07777, putative succinyldiaminopimelate transaminase DapC.	0
NZ_AP022565.1\|WP_163667684.1\|4643051_4644041_+\|TIGR03560-family-F420-dependent-LLM-class-oxidoreductase	gnl\|CDD\|274648	TIGR03560, F420_Rv1855c, probable F420-dependent oxidoreductase, Rv1855c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes one such subfamily, exemplified by Rv1855c from Mycobacterium tuberculosis. [Unknown function, Enzymes of unknown specificity].	1.79716e-104
NZ_AP022565.1\|WP_163667687.1\|4644021_4644729_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	1.63204e-16
NZ_AP022565.1\|WP_163667654.1\|4632159_4633242_+\|CoA-transferase	gnl\|CDD\|224717	COG1804, CaiB, Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion].	5.23311e-113
NZ_AP022565.1\|WP_163670246.1\|4646193_4646874_-\|LpqN/LpqT-family-lipoprotein	gnl\|CDD\|378485	pfam10738, Lpp-LpqN, Probable lipoprotein LpqN. This family is conserved in Mycobacteriaceae and is likely to be a lipoprotein.	7.30497e-46
NZ_AP022565.1\|WP_163667651.1\|4630474_4632142_-\|alpha-keto-acid-decarboxylase-family-protein	gnl\|CDD\|226470	COG3961, COG3961, Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only].	0
NZ_AP022565.1\|WP_163667669.1\|4636876_4637983_+\|alkene-reductase	gnl\|CDD\|239243	cd02933, OYE_like_FMN, Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Members of OYE family include 12-oxophytodienoate reductase, pentaerythritol tetranitrate reductase, morphinone reductase, and related enzymes.	1.17758e-161
NZ_AP022565.1\|WP_163667678.1\|4641979_4642567_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	5.11245e-20
NZ_AP022565.1\|WP_163667661.1\|4634193_4635069_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	1.0697e-22
NZ_AP022565.1\|WP_163667672.1\|4638334_4639546_+\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|236197	PRK08242, PRK08242, acetyl-CoA C-acetyltransferase.	0
NZ_AP022565.1\|WP_163667663.1\|4635133_4635583_+\|SRPBCC-family-protein	gnl\|CDD\|176861	cd07819, SRPBCC_2, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	9.25873e-46
NZ_AP022565.1\|WP_163667648.1\|4630029_4630470_+\|SRPBCC-family-protein	gnl\|CDD\|176861	cd07819, SRPBCC_2, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	3.86201e-57
NZ_AP022565.1\|WP_163667675.1\|4639557_4641705_+\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|183293	PRK11730, fadB, fatty acid oxidation complex subunit alpha FadB.	2.46484e-142
NZ_AP022565.1\|WP_163667642.1\|4627738_4628344_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	3.88791e-17
NZ_AP022565.1\|WP_163667681.1\|4642571_4642997_-\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|274679	TIGR03618, Rv1155_F420, PPOX class probable F420-dependent enzyme. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity].	1.15176e-08
NZ_AP022565.1\|WP_163667657.1\|4633301_4634201_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	7.69751e-17
NZ_AP022565.1\|WP_163667645.1\|4628393_4629950_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	4.73499e-79

>NZ_AP022565.1|WP_163667669.1|4636876_4637983_+|alkene-reductase
MTYKLNADAALLQPIQVGDTAAANRLFMAPLTRSRADADGTPSPLAAQYYSQRAGAGVIISEATAVAETANGAYLNTPGIYTDRHQQGWAEIADSVHAAGGKMFVQLWHVGRMAHPEISGFEAVAPSAIAADVVTHTPTGKKALQTPRALDTAEIPAIVEQFRTAARRAIDAGMDGVEIHGANGYLLHQFASDVVNQRTDAYGGSPENRARLTAEVVEAVVDEIGAGRVGLRISPGNTAGDMHENDTVGAYEALLARIAPLGLAYLHVLIDPATRTFGVIRALWSGTFVLNTGRASGTDFSALEGYAEWGAISAAAVGRAYLANPDLIDRLILGAELNEPDVSTFYAPGPSGYTDYPSLIEIEEPRSA
>NZ_AP022565.1|WP_163667666.1|4635583_4636753_-|pyridoxal-phosphate-dependent-aminotransferase
MTVQRLQPFAVTIFAEMSALAGRLGAVNLGQGFPDEDGPAEMLKVAQHAISEGHNQYPPGLGIPELRHAIAAQRKRHYGIDYDPDTEVLVTVGATEAIAASVLGLVEPGSEVLVIEPFYDSYSPVIAMAGCVRSAVPLVADGTGFAIDVEGLRRAVTPKTRALILNSPHNPTGAVASDAELRAIAALAIEHDLLVITDEVYEQLVFGVEHLPLAGYPGMAERTVTISSAAKMFNVTGWKIGWACGPTELIAGVRAAKQYLSYVGGGPFQPAVAHALNHEDGWVADLRESFQTKRDRLGNALADIGFEVHDSRGTYFLCADPRPLGYSDSTQFCAELPHTAGVAAIPMSAFCDAEAPHADLWNHLVRFAFCKRNDTMEEAIRRLDVLRRR
>NZ_AP022565.1|WP_163667663.1|4635133_4635583_+|SRPBCC-family-protein
MAVQASREAVFDSSPEAIMEVLADVDALPSWSAMHRRVKVIDRYPDGKPHHVKTTLRVLGITDKELLEFHWGDHWMVWDAEPNRQQCGQHVEYNLTPEVDRTRVRFDVIVDLAVPVPEFLIKRAKTLVLDVAIERLRQRVMRNSRHRLI
>NZ_AP022565.1|WP_163667661.1|4634193_4635069_+|universal-stress-protein
MPEHNLRHGIVVGVDGSPASDNAVSWAAKAAVSRSVELTLVYASPGAASPVWLDVALPQEYWDYQDQQGQEVLDAARRVAADAAGTHPLNIVAKAVPGHAVATLIEYSRQAELVVVGSRGLGKWGRRLLGSVSSSLAHHAHGPVAVIPHDERPSTAPVVVGVDGSPASELATAIAFDEASRRGVELVVLHTWTDLNFEFPSVRWEDLSSEAERALAEQLAGWGERYPDVAVRRVVMPDQPARQLLAQAETAQLVVVGNRGRGGFAGMLLGSVSSAVVHSSTAPVIVARQSN
>NZ_AP022565.1|WP_163667657.1|4633301_4634201_+|universal-stress-protein
MTSSDAPVVVGIDGSDGALGAARWAGAVAARFGAPLRIVHALPSIGRNLTQTAAALTAAMMSYQRDMAQAFLKAAEEAVRADHPELSVSTDSFNEPADQVLIEASRQARLVVLGGKTVTPAAALLLGSTALSVATRAACPVVAFRGDRVDPGDGPVIVGVDDSPAAQTALETAFEFADRFGQSVNAVRSLSLTAPAETGVTIPLLIDWDGVESAELMALTETVDVHNKNHPGVDAKCFIEPDSPGKAVLKHVDDSGLVVVGSRGRNALAGVLLGSTSLNLLHHSPVPVMICRAQGDSDA
>NZ_AP022565.1|WP_163667654.1|4632159_4633242_+|CoA-transferase
MTNTGPLAGVRVIELGGIGPGPHAAMMLSDLGADVVRVRRPGGLTMPAENVDLMHRGKRIVDLDVKSEPGKLLDLVAKADVLLDCFRPGTCERLGIGPAECEAVNPRLIFARITGWGQDGPLATTAGHDINYLSQTGALSAIGYRDRPPVAPLNLVADFGGGSMLVVVGIVTALYERERSGKGQVIDAAMVDGVSMLAQMMWTMRATGSLRDERESFLLDGGAPYYRTYETSDGGYMAVGSIEPQFFAQLVAGLGLDAAEIPGQFELARYDQMRAIFTERFATKTRDEWTEIFAGTDACVTPVLTWGEAAEGEHLLARSTLVTVDGVAQAAPAPRFSRTPPSSPGQPPQSSTDIDDIGWT
>NZ_AP022565.1|WP_163667651.1|4630474_4632142_-|alpha-keto-acid-decarboxylase-family-protein
MGEIGYTVGDYLLDRLAELGVTEMFGVPGDYQMEFLDHILAHPTLRWVGGANELNAGYAADGYGRLRGMAALVTTFGVGELSAANAIAGSYAEHVPVVHIVGAPSKDSQAARRIVHHTLGDGDFDHFLRISREITCAQADLAPATATREIDRVLSEVREQKRPGYLLIATDVARFPTERPTTPLPRYTGGTSPRALAMFTAAAAEMIADHRLTVLADFLVHRLDCVDQLNALLAADTIAHATLMWGKSLVDESSPNYLGIYAGAASEDSVREAIEDAPVLVTAGVLFTDMVSGFFSQRIDPARTIDIGVNQSVVAGQVYAPLDMSAALDAVTAILTERGITSPALPPLPARPHTDPPAREAALTQEALWDRLSQALTPGNVVLADQGTSFYGMAGHRLPSGVTFIGQPLWGSIGYGLPAALGAGLADRDRRTVLLIGDGAAQLTIQELGAFGREGLSPVVVVVNNDGYTVERAIHGVTAEYNDITGWRWTELPAALGVSDALTFRVSTYGELDDALTTAAATPDRMVFVEVMLGRMDIPPLLTELAQSAADANSS
>NZ_AP022565.1|WP_163667648.1|4630029_4630470_+|SRPBCC-family-protein
MATSDSREVVIEATPQEILDVVADVEATPTWSPQYQRAEILESYDDGRPKQVKMTVKAAGLTDEQVIEYTWSENKVSWTLVRAGQLKAQDASYTLTPDGDKTKVRFDITIDLSVPMPGFILKRTMKGGVETATEGLRKQVLKVKKG
>NZ_AP022565.1|WP_163667645.1|4628393_4629950_+|FAD-dependent-oxidoreductase
MAEYDAIVIGAGHNGLAAAALLARAGRRTLCLEAKRYAGGMASTVELFDGYRFEIAGSLQFPTSAVVSAELGLDTLPTVGLEVMSVSLRGIGDRPVVYYADPMKMLGHLGEVHGADAVAGMAGLMTWSLAPTRALGRFDAGRPPRTLDEMYACAATESERLAIDDLLFGSVSDVLDRYLPDKDKHGALRGMLAFLAVNTTYRGPETPGSAAALAYGLAVPDENAVLMKKLAGGIGALTDHLHALLTAAGGELRLRSSVDRIAVDNGRITGVRLADGTTITAPVVVSAIAPDITVTKLIDPEALPAEVRERFTRIDHRGSYLQMHFALDGAPTFDAPYELLNDPEMQAAIGIFSTPEELQQQWQDARRGIVPADPAVAFQIPSAHDPTLAPPGKHAASAFALWFPVEESASGYGELKDEMGRRVIEKISRLAPDFEQRIIRHTTFTPRHMGTMFGAPGGDYCHGLIHPEQMGPNRPGPKGHVGQPIPIDGLYLASAGCHGGPGITFIPGYNAAKAVLGD
>NZ_AP022565.1|WP_163667642.1|4627738_4628344_+|TetR-family-transcriptional-regulator
MAKPAQTARSERTREALRQAALVRFLAQGVEDTSAEQIAADAGVSLRTFYRHFTSKHDLLFADYDAGLHWFRAALAERPASESILDSVQSAILAFPYDVDAVTKIAGMRAVELDPDRIVRHIRQVESDFADAVAELLVARSGQLPQGDDRLRIAVTARCVAASVFGAMELWMIGNEAGERSLPELARMCRTALEALRSGLA
>NZ_AP022565.1|WP_163667672.1|4638334_4639546_+|acetyl-CoA-C-acetyltransferase
MSEEAFIYEAIRTPRGKQRGGALNEIKPVNLVVGLIEEIRSRYPDLDETLISDVILGVVSPVGDQGGDIARTAGLVAKLPETTGGFQLNRFCASGLEAVNLAAQKVRSGWDDLVLAGGVESMSRVPMGSDGGAWASDPETNYRIGFVPQGIGADLIATIEGFSRDDVDAYAARSQEKAAAAWSGGYFAKSVIPVKDQNGLVVLDHDEHMRPGTTAADLGKLKSAFEGLGAMGGFDDVALQKYHFVEKINHVHTGGNSSGIVDGAGLLLIGSESAGASQNLTPRARIVATATSGADPVIMLTGPTPATKKVLDRAGLTVDDIDLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMITGTMVDELERRGARRALITLCIGGGMGVATIIERV
>NZ_AP022565.1|WP_163667675.1|4639557_4641705_+|enoyl-CoA-hydratase/isomerase-family-protein
MAENTIQWDKDADGIVTLTLDDPTGSANVMNEHYKQSMHDAVEKLVAEQDSITGVVITSAKKTFFAGGDLKGMMNIGPDDAAEAFEMVETIKADLRKLETLPKPVVAAINGAALGGGLEIALTCNHRIAADVKGSQIGLPEVTLGLLPGGGGVARTVRMFGIQKAFMEILSQGTRFSPAKAAEIGLVDRVVPNVDELLPAAKAWIKANPEAHTQPWDVKGYKMPGGTPSSPALAAILPSFPALLRKQLKGAPMPAPRAILDAAVEGAQVDFDTASRIESRYFVSLVTGQTAKNMIQAFFLDLQAINGGASRPEGIAKQEIKKIGVLGAGMMGAGIAYVSAKAGYDVVLKDVTQEAADKGKAYSEGLEAKALKRGKTTEEKSKALLAKITPTADPQDLKGVDFVIEAVFENQELKHKVFQEIEDIVEPNALLGSNTSTLPITGLATGVKRQEDFIGIHFFSPVDKMPLVEIIKGEKTSDEALARVFDYTLAIRKTPIVVNDSRGFFTSRVIGTFVNEALAMLGEGVAPASIEQAGSQAGYPAAPLQLSDELNLELMHKIAVATKEGVEAAGGTHVPHPAEAVVEKMIELGRPSRLKGAGFYEYVDGKRTQLWPGLKEAFNSGSASIPLQDMIDRMLFAEALETQKCIDEGVLTSTADANIGSIMGIGFPPYTGGSAQFIVGYQGELGVGKAAFVARAKELAARYGDRFLPPASLES
>NZ_AP022565.1|WP_163667678.1|4641979_4642567_-|methyltransferase-domain-containing-protein
MSSRQRLFRWLYRLGFTPWDGHPLAHSLMTLVEGTALPPGTALDVGCGTGDNAVYLARHGWRVTGVDYVAKPLKIARAKAAGLPAVFTKADVTQLSWSGVGAGFDLIVDSGCLHGMDADDRDAYVREVSAVAAPDAQLLIVAFIPGGSMGVPGIGFEEVQRRFSAGWILLSSGDEPAMNQNGKNAARFYLFRRTT
>NZ_AP022565.1|WP_163667681.1|4642571_4642997_-|pyridoxamine-5'-phosphate-oxidase-family-protein
MPLSKEEREQFLAEPHIAALSVYAGDKRGPLTVPIWYQYTPGGQPWLLTGTGSRKHRLIEAAGHLSLMVERLEPTVRYVAVDGAVDRIEPGTDEQLVEMTKRYLAPEKVEPYLEFARREQGESVAVFFKPEHWLSSDLGAL
>NZ_AP022565.1|WP_163667684.1|4643051_4644041_+|TIGR03560-family-F420-dependent-LLM-class-oxidoreductase
MRFGLFIPQGWRLDLVDIPTENHWPVMRDLAAYADAGSWDSLWVYDHFHTVPVPTDEATHEAWSLMAAHAATTSRIKLGQMCTAMSYRNPVYLAKIAATTDIISGGRVQMGIGGGWYEHEWRAYGYGFPSAGVRLGRLDEGVQIMRDAWRVGRVSFDGKHYQVDGAIVAPKPLQDNGIPMWIAGGGEKVTLRIAAKYAQYTNFTSEPDGFAHKSEVLAGHCRDVGTDYDTIVRSANFNAVIGESEADVAARVARLRARQVPVAGEAAVDAMLANATAPESASGTTEQVIEKLQRMRDLGCEYAILYFPEAAYDRSGIELFEQKVIPALS
>NZ_AP022565.1|WP_163667687.1|4644021_4644729_-|helix-turn-helix-domain-containing-protein
MFSRSAHPATMSALSTLDDPLRRRLYQLVADSDEPVSREDAAAATGIGRTLAAYHLDKLADAELLAVTYQRPDGRSGPGAGRPAKLYSLAERELAISVPPRDYQLLAGILVTSIEQDTGGAVRATVEQAARDAGMRAAHDAGGDLIDALRGCGYLPRTDPDGGISLRNCPFHAVARDHLDVVCGLNLELIRGAIAASSSSTAQAELNPRPGHCCVQLHDADRQHRVSDPVNSTPG
>NZ_AP022565.1|WP_163667690.1|4644820_4645279_+|hypothetical-protein
MSTSNVGIGQPAGWAAAVERARTDPAYGAYALLRIGFTVLPIVFGIDKFTDLLTNWDSYLAPWIADLSPFGAHSTMLVVGVIEIVAGVAVAVKPRYAAYVVAAWLAGIILNLVSYPGFYDVALRDFGLLLAALTLARLAWVYDPAWHRAGTH
>NZ_AP022565.1|WP_163667693.1|4645460_4645784_+|hypothetical-protein
MAAVFNRRPRTAPLAAAPVDCSRPVHSADIAQSRLFEEILLGEIDDLRDHLAATELRWRKLRERSRVADAPIPEALVRLHGRIAEAERLLVQLRCRFGYGEDPLRVI
>NZ_AP022565.1|WP_163667696.1|4645824_4646148_-|hypothetical-protein
MTRIKASTLLLALLGFVLFLSGPVITAPPAYAACAPNQQLDPRTGMCWSTADRNTVGTPRGTGGTAPCIPGRLGMCLAAAQNGTQPGANLKPQPPGGPAPRTTWPAR
>NZ_AP022565.1|WP_163670246.1|4646193_4646874_-|LpqN/LpqT-family-lipoprotein
MRKMLVATTTGLTAAALSFAIAGCGPSGESKSTTSESTAVTAVQDQPPKLEDGLDDTLHDYIVEHNIAEVPFKPGDPGTPTYDLALPEHWALATEIPEWAFGAIVYDQPRDASDPPTITAIANKLTGDVEGPEVLDYASGLLDNMPDFKPLGEATERTISGFNSVDYAGTYLHEGKTRFVAQKTVVVPGPDALFVVQLNGTAVESDSQIVLDAMQWINDRTTITAA

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Crispr_ID: NZ_AP022565_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022565_5

4794394-4794528

Orphan

Consensus_repeat	Method
GACGCGGTGCTTCGCCGTTTCCTACCTGAGGGTCGCTGTGCCACGCGATCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022565_5

>merge|NZ_AP022565|5|4794394-4794528|CRISPRCasFinder
GACGCGGTGCTTCGCCGTTTCCTACCTGAGGGTCGCTGTGCCACGCGATCGACAGCCCTGGGGTAGAAATCGGCGGGAACGGCTGACGCGGTGCTTCGCCGTTTCCTACCTGAGGGTTGCTGTGCCACGCGATCG

>NZ_AP022565|5|5|4794394-4794528|CRISPRCasFinder
GACGCGGTGCTTCGCCGTTTCCTACCTGAGGGTCGCTGTGCCACGCGATCG	ACAGCCCTGGGGTAGAAATCGGCGGGAACGGCT
GACGCGGTGCTTCGCCGTTTCCTACCTGAGGGTTGCTGTGCCACGCGATCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022565.1\|WP_163667994.1\|4789583_4791056_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236768
NZ_AP022565.1\|WP_163667984.1\|4784224_4785751_+\|acetyl-CoA-acetyltransferase	unknown	unknown	gnl\|CDD\|236204
NZ_AP022565.1\|WP_163668018.1\|4804888_4806406_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022565.1\|WP_163667998.1\|4791692_4793261_+\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234854
NZ_AP022565.1\|WP_163668014.1\|4801826_4802501_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022565.1\|WP_163667981.1\|4783020_4783812_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022565.1\|WP_163667992.1\|4788698_4789523_+\|DUF5336-domain-containing-protein	unknown	unknown	gnl\|CDD\|375092
NZ_AP022565.1\|WP_163668002.1\|4794627_4795641_-\|alpha/beta-hydrolase-fold-domain-containing-protein	unknown	unknown	gnl\|CDD\|223730
NZ_AP022565.1\|WP_163667988.1\|4786451_4787300_-\|TIGR03619-family-F420-dependent-LLM-class-oxidoreductase	unknown	unknown	gnl\|CDD\|274680
NZ_AP022565.1\|WP_163667983.1\|4783827_4784121_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376737
NZ_AP022565.1\|WP_163667996.1\|4791066_4791696_+\|phosphoribosylglycinamide-formyltransferase	unknown	unknown	gnl\|CDD\|235544
NZ_AP022565.1\|WP_163668010.1\|4798420_4799803_+\|sigma-54-interacting-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224160
NZ_AP022565.1\|WP_163668020.1\|4806683_4807265_-\|DUF1707-domain-containing-protein	unknown	unknown	gnl\|CDD\|377959
NZ_AP022565.1\|WP_163667990.1\|4787430_4788564_+\|dimethyl-sulfone-monooxygenase-SfnG	unknown	unknown	gnl\|CDD\|274923
NZ_AP022565.1\|WP_163667986.1\|4785881_4786367_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022565.1\|WP_163668008.1\|4796444_4798295_-\|LpqN/LpqT-family-lipoprotein	unknown	unknown	gnl\|CDD\|270916
NZ_AP022565.1\|WP_163668006.1\|4796072_4796435_+\|hemophore-related-protein	unknown	unknown	gnl\|CDD\|374603
NZ_AP022565.1\|WP_163668016.1\|4802978_4804511_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237871
NZ_AP022565.1\|WP_163668012.1\|4799795_4801784_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|227204
NZ_AP022565.1\|WP_163668004.1\|4795695_4795947_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP022565.1\|WP_163667994.1\|4789583_4791056_+\|hypothetical-protein	gnl\|CDD\|236768	PRK10819, PRK10819, transport protein TonB; Provisional.	3.29769e-05
NZ_AP022565.1\|WP_163667984.1\|4784224_4785751_+\|acetyl-CoA-acetyltransferase	gnl\|CDD\|236204	PRK08257, PRK08257, acetyl-CoA acetyltransferase; Validated.	0
NZ_AP022565.1\|WP_163668008.1\|4796444_4798295_-\|LpqN/LpqT-family-lipoprotein	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.66148e-93
NZ_AP022565.1\|WP_163667992.1\|4788698_4789523_+\|DUF5336-domain-containing-protein	gnl\|CDD\|375092	pfam17270, DUF5336, Family of unknown function (DUF5336). This Actinobacterial family of proteins has no known function. Most of the family members are predicted to have have 4 trans-membrane regions.	5.36301e-35
NZ_AP022565.1\|WP_163668002.1\|4794627_4795641_-\|alpha/beta-hydrolase-fold-domain-containing-protein	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	4.17413e-44
NZ_AP022565.1\|WP_163667988.1\|4786451_4787300_-\|TIGR03619-family-F420-dependent-LLM-class-oxidoreductase	gnl\|CDD\|274680	TIGR03619, F420_Rv2161c, probable F420-dependent oxidoreductase, Rv2161c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity].	1.05737e-90
NZ_AP022565.1\|WP_163667983.1\|4783827_4784121_-\|hypothetical-protein	gnl\|CDD\|376737	pfam02152, FolB, Dihydroneopterin aldolase. This enzyme EC:4.1.2.25 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.	0.000448577
NZ_AP022565.1\|WP_163667996.1\|4791066_4791696_+\|phosphoribosylglycinamide-formyltransferase	gnl\|CDD\|235544	PRK05647, purN, phosphoribosylglycinamide formyltransferase; Reviewed.	3.12817e-105
NZ_AP022565.1\|WP_163668010.1\|4798420_4799803_+\|sigma-54-interacting-transcriptional-regulator	gnl\|CDD\|224160	COG1239, ChlI, Mg-chelatase subunit ChlI [Coenzyme metabolism].	7.65086e-108
NZ_AP022565.1\|WP_163668020.1\|4806683_4807265_-\|DUF1707-domain-containing-protein	gnl\|CDD\|377959	pfam08044, DUF1707, Domain of unknown function (DUF1707). This domain is found in a variety of Actinomycetales proteins. All of the proteins containing this domain are hypothetical and probably membrane bound or associated. Currently, it is unclear to the function of this domain.	8.9961e-19
NZ_AP022565.1\|WP_163667990.1\|4787430_4788564_+\|dimethyl-sulfone-monooxygenase-SfnG	gnl\|CDD\|274923	TIGR04021, LLM_DMSO2_sfnG, dimethyl sulfone monooxygenase SfnG. This family of FMNH2-dependent members of the luciferase-like monooxygenase (LLM) family includes SfnG, a monooxygenase that converts dimethylsulphone (DMSO2) to methanesulphonate. This step can be followed immediately by methanesulfonate sulfonatase (an alkanesulfonate monooxygenase - see TIGR03565) for the FMNH2-dependent conversion an inorganic form. [Central intermediary metabolism, Sulfur metabolism].	0
NZ_AP022565.1\|WP_163667998.1\|4791692_4793261_+\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	gnl\|CDD\|234854	PRK00881, purH, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional.	0
NZ_AP022565.1\|WP_163668006.1\|4796072_4796435_+\|hemophore-related-protein	gnl\|CDD\|374603	pfam16525, MHB, Haemophore, haem-binding. MHB is a coiled-coil molecule that binds free haem in mycobacterial cytoplasm to deliver it to membrane proteins for shuttling through the membrane.	1.43613e-30
NZ_AP022565.1\|WP_163668016.1\|4802978_4804511_+\|hypothetical-protein	gnl\|CDD\|237871	PRK14965, PRK14965, DNA polymerase III subunits gamma and tau; Provisional.	0.00256346
NZ_AP022565.1\|WP_163668012.1\|4799795_4801784_+\|VWA-domain-containing-protein	gnl\|CDD\|227204	COG4867, COG4867, Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only].	0

>NZ_AP022565.1|WP_163667998.1|4791692_4793261_+|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase
MSEKKPIRRALVSVYDKTGLADLARGLHEAGVTIVSTGSTAKTIAAAGVPVTPVEEVTGFPEVLDGRVKTLHPRVHAGLLADTRKPEHVAALQELEVEAFELVVVNLYPFSETVESGASVDECVEQIDIGGPSMVRAAAKNHPSVAVVVDPRGYDGVLAAVRAGGFTLEERKKLASLAFRHTAEYDVAVAGWMGSTLAPAEDSVPASLPQWFAGTWHRSAVLRYGENPHQQAAVYRDDSAWPGLAQAEQLHGKEMSYNNYTDADAAWRAAFDHEEICVAIIKHANPCGIAISSESVADAHRKAHECDPLSAFGGVIASNTEVSVEMAETVADIFTEVIIAPAYEAGAVEILARKKNIRILVASEPLVGGIELRQISGGVLLQQRDALDAEGDNPANWTLATGEPADPQTLSDLVFAWRACRAVKSNAIVIAKDGATVGVGMGQVNRVDAAGLAVQRAGDRVPGSVGASDAFFPFPDGLETLTNAGVKAIVHPGGSVRDAEVTAAAEAAGITLYLTGARHFAH
>NZ_AP022565.1|WP_163667996.1|4791066_4791696_+|phosphoribosylglycinamide-formyltransferase
MQQPLQVPPSAPARLVVLASGTGSLLASLLAAAVDDYPARVVAVGTDRKCAAVDIAAEAGVPSYTVRLGDYDDRDAWDAALIEATAEHEPDLVVSAGFMKILGGQFLSRFPGRVVNTHPALLPAFPGAHAVPDALAYGVRVTGCTVHLVDSGMDTGPILAQQAVDVLDDDTEQTLHERIKVVERRLLVDVLAALATRGVTWTGRKATIG
>NZ_AP022565.1|WP_163667994.1|4789583_4791056_+|hypothetical-protein
MSNRPVGTRQARELLRVAFGPSVVALVVIAAVVLLQLLIANSDMTGALGATASMWLGVHQVPVSIGGRELGVMPLLPVMAMIWGTARTTAAATAPNSSWFVTRWVVASALGGPILIAAILLAVIHDAASVISELQTPSALRAFCSVLVVHAIGALIGVGSKVGRRTLAVLPLPVWLPDAFRAAAAGVLALFGLSGVVTAVSLVVHWGTMHDLFAITDSLFGQLSLTLLSILYIPNVIVGASAIAVGSSAHVGLAAFSSFTVFGGDIPAVPVLAAVPTPPLGPIWVALLIVGAASAVAVGQQCARRPLPIGAATGKLVAASALAAVTMALAGFAGGGRLGNFGSVGVDQATFGPAVFLWFVGIGGLTVAMSGGLTRKPRPVAPSPPPPPAEPEPEGEPEPEPEPEDDVDVVEAAPEFEPDEPLVSWSAEEPGDDSESPQDEYEDYDDVQETGYEPGPRSYEDFDDDPEDHFIVDDIPDDDLTGDQPRRAGD
>NZ_AP022565.1|WP_163667992.1|4788698_4789523_+|DUF5336-domain-containing-protein
MTYPPSNPGYPPQSGSQFDATQQFAKAVPAPAAPPAAPAASEPGENKLPEILLGVVAVTGLLIYFVSFAFEIQAVIGSLIIAVPLLAGLLAGVSVLPKQKSRVAPAAVLSTLGLLLAITLSVAAGSDADWTIWVLLVLTLVQAGAGIAALLFDAGILTPPAPKPQFDPQPQYGQYGGPSQYYGQQHQPQQHGGQSYQQAQSQQPGYPSQYGGYAGGQNTGGFPVQPPQGQQPSGPPTPPTGYPTYGQPQHSGSSAPSAGPAQQPPSQQSGPAPS
>NZ_AP022565.1|WP_163667990.1|4787430_4788564_+|dimethyl-sulfone-monooxygenase-SfnG
MTTERIADHVKFAYWVPNVSGGLVTSDIEQRTDWNYEYNKKLAQTAENNGFEYALSQVRYEASYGAEYQHESTSFSLALLLATERLKVIAAVHPGLWQPAVLAKLGATADHLSGGRFAVNVVSGWFKDEFTHLGEPWLEHDERYRRSAEFLQVLREIWTNDDPVEFRGDFYRIHDFTLKPKPLNTSERPNPELFQGGNSTAARRNGGRYADWYFSNGKDFDGLTEQVVEVRHHARNADREVKFGLNGFIIARDTEKEAKETLREIIAKANRPAVEGFRSAVQQAGNSTGDKKGMWADSSFEDLVQYNDGFRTQLIGTPEQIAERIAAYRKRGVDLILGGFLHFQEEIEYFGANVLPLVREIEAAETDSAETPVLVRA
>NZ_AP022565.1|WP_163667988.1|4786451_4787300_-|TIGR03619-family-F420-dependent-LLM-class-oxidoreductase
MDYGLVLFTSDRGIAPAKAAKLADDHGFTTFYVPEHTHIPIKREAAHPTTGDESLPDDRYMRTLDPWVSLGTACAVTSRVRLSTAVALPVEHDPITLAKSIATLDHLSGGRVSLGVGFGWNTDELADHKVPPGRRRTMLREYLEAMRALWTEEEASYDGEFVNFGPSWAWPKPVQSHIPILVGAAGNEKNFKWIAKSADGWITTPRDFNIDEPVKLLQDTWAAAGRDGAPQIVALDFKPDPEKLAHWRELGVTEVLFGLPDKSEAEVSAYVERLAGKLAALD
>NZ_AP022565.1|WP_163667986.1|4785881_4786367_-|hypothetical-protein
MRTAGRLVVCLIALLAACAPATRPSDGKGFPDFSGYAPADHDTYFSAGQRYSGYSFRTPSGLTCDSNDYPDPESARIQCWGPRPDKGPGLWLVAAERRSAATIRQLADPDDPQATPPPLLPAQHVVRYPKDDLVCGVGSHITACRIGRHGFVLGPQWSRLF
>NZ_AP022565.1|WP_163667984.1|4784224_4785751_+|acetyl-CoA-acetyltransferase
MVDPRTPVIVGVGQFTERIDLDGYRGMSSVELATEAAKAALRDCGADSAAVAQAIDTVAGTRQFEISGPQTPTLGVSNNYPRSVARNVGAEPARAILEVIGGQSPQHLVTEFSSAIAAGDAEVVLLFGSENTSTLRHFSKRDDKPDHSETVEGQLEDRGYGYDGIFDEYTIKHGLIGAPVQYGLLENARRARVGLSVSDYRTQMAELFAPFSKVAEKNPYSSAPVERSAQELATVTESNRMICDPYPRMMVARDQVNQGAAVLLMSVEAARKLGVPEEKWVYLRGHADMKEIKLLERAELGYSDAANIAVNEALRVADITLDDIAAFDLYSCFPFPVFNICDGTGLAPDDERGLTLTGGLPFFGGPGNNYSMHGIAEAVNEMRDKPGQFALVGGNGGIASKYSVGIYSTEPADWVADGSAALQDAFNIQERVVIAEKADGPATIETYTVRYDWTPLTGIIIGRLDADGSRFLATTTDEALVELLTDGEPLGASIIVQSGEKRNTATLA
>NZ_AP022565.1|WP_163667983.1|4783827_4784121_-|hypothetical-protein
MTQPLKVDTAALEWAARELAAASDDLGDSLTYEWRPPADQPSAKATVAVTAAAHHVMSECSANLLHFADSIAQAARYYDATDSANAQAVIKTMNPPK
>NZ_AP022565.1|WP_163667981.1|4783020_4783812_-|hypothetical-protein
MLTRSRVEGWTTGHLKSASLGWERAASIIDEHYSKAQSTVGGVPWTGPASDRANGKLFENLAKVRKSLDLIRQASGIAKAGAESIGAAKNDAVNAIKNVEGQFFSVSEDLTVTDRLPWIIGPALALMRKLRATHAQADIRAKATVLEWTDQNVADQLDTMTSRLREFDLQGGKGESGAGSSKDPQITGCPGPLRPDGTQGDLNSTLPGTGIEISGDGRTGYPTLNGQKNPLEIEANQPSPENPDGKDKVRPLPTASDRHDCWS
>NZ_AP022565.1|WP_163668002.1|4794627_4795641_-|alpha/beta-hydrolase-fold-domain-containing-protein
MNSLDWRSRPTTVHFGPASLQSRALGWITAIFVRPLLGLLTLIGLGINRVAPALLQRARLDVIDRPLRFVKPLPGTEVTPVALPNCPAEWVIAPEARDSDRVIVYLHGSALVTLGLNSHRRFVSKLSAATGARILNVGYRLAPQADIDDAVADGLDSYRLALSLGFAPDRIVLAGDSAGGLMAADTALAARDAGLPVPAGQVLLSPLTSSDMDLKYRALQEHRDVLFPFMTVKFIYDVFATVNGTRPTPVMPPEADLHGLGPFLLQVGTHEMLLNDTFALADRLQATGVPVWVQVWDRAMHMFQLSFDVNPDARHAVDEIASFIAYATTDVEDEVSA
>NZ_AP022565.1|WP_163668004.1|4795695_4795947_-|hypothetical-protein
MSHMRNLVIFGAAGFGLAAAILCAPTAAADPSLLPQCEVTGGSSIAGGQTTDCASEGNVQIDATPPVYPGEEEFYGFPGFGFI
>NZ_AP022565.1|WP_163668006.1|4796072_4796435_+|hemophore-related-protein
MKLVTRSRSCAVAVLGAGAMLLGTSATASAEPPNCTTADVTAVMGGVSTEMSDYLFAHPDVNAFFSGLQGQGKKTTADKTKAYLNDNPQVRAELDAIRAPALDLRNRCNIPLEAEISGVI
>NZ_AP022565.1|WP_163668008.1|4796444_4798295_-|LpqN/LpqT-family-lipoprotein
MPLASGQEFAGFTIVRLVGTGGMGEVYLASHPRLPREDALKVLPISVSSDNEFRQRFIREADMAATLWHPHIVGVHDRGEFEDRLWISMDYVDGHDAAKLLHDQFPKGMPAEDVIEIVTAVGDALDYAHQRNLWHRDVKPANILVTSKQGGKRRIMLTDFGIARRADEVNGLTSTNITVGSMSYTAPEQLMGQPLDGRADQYSLAATAYRLFTGTPPFAHSNPAVVISHHLNSPPPKLADTKPELAVFDSVMAKALSKDPKDRYDTCHDFAVALAEAATGTTPEVRTPAPVHEPAPPTTPLIIPKPVNPPPLPPPSPRQTAPSEPPVFTSSWTGSETSTHKPATSQPAGGMQGLGGPSGPPGPVGPPQTNFGPPPLPHNPTPQKPDDRRKLVVAAAAIGGVLLLVAGITFAVTSGGEETNGGETTSAAATDTSGETTSPPKPVHAFTIADYIKQSGAIETPVHRGDPGAPVFNWPTPPGWTDAGTRTPAWAYSAMINDSVNPADAPSVVSLISKLTGNVDANKLLEYAPSELQNLADYKPNGDVTRAEISGFPSVHLGGTYAKGDQRRAITQTTIVIQAPGAVYVLQVNADAPERDKGVLTEVNKAIEAQATVALP
>NZ_AP022565.1|WP_163668010.1|4798420_4799803_+|sigma-54-interacting-transcriptional-regulator
MSQPKDLPRTVGELRASGHRERGVKAEIRENLLSALADRRDVWPGILGFEDTVIPQLERALIAGHDVVLLGERGQGKTRLLRALTGLLDEWTPVIAGSELGEHPYSPITPESIRRAADSGDDLPIDWRHRSERYTEKLATPDTSVADLVGDIDPIKVAEGRSLGDPETIAYGLIPRAHRGIVAVNELPDLAERIQVSMLNVMEERDIQVRGYTLRLPLDVLVVASANPEDYTNRGRIITPLKDRFGAEIRTHYPLEIDDEVGVIRQEAQLAAEVPEYLIGVLARFARNLRESSSIDQRSGVSARFAIAAAETVAASARHRSAILGEDDPVARVVDLATVIDVLRGKLEFESGEEGREQAVLEHLLRRATADTAQRLLGGIDVAPLVAAVEEGSPVTTGERVSAKDVLAALPDLAVVDALADRVGAVSVGQRAAAIELALEALYLAKRVDKVTGEGETVYG
>NZ_AP022565.1|WP_163668012.1|4799795_4801784_+|VWA-domain-containing-protein
MADPGRAHGHTSRYSRYTGGPDPLAPPIDLRDALEQIGQSVMEGSSPRRALSELMRRGTEGMRGTDRLAAEANRKRRELLQRHNLDGTLQEIKKLLDEAVLAERKELARALDDDARFGELQMEALSPSPAKAVQELTDYDWRSPEARQKYEQIKDLLGREMLDQRFAGMKEALENATDEDRQRVNDMLDDLNELLDKHAQGNDSPQDFQDFMDKHGEFFPEGPQNIDELLDSLAKRAAAAQRFRNSLSAEQRAELDSLAQQAFGSPSLMNALDRLDSHLQAARPGEDWNGSERFSGGDPLGMGEGAQALSDIAELEQLADALSQSYSGASMDDVDLESLARQLGDDAAIDARTLAELEKALVNQGFIDRGSDGQWRLSPKAMRQLGQTALRDVAQRLSGRHGERDTRRAGAAGELTGATRPWQFGDTEPWNVTRTVTNAVLRQAGTGIAERPIRFAVEDVEISETETRTQACVALLVDTSFSMVMENRWLPMKRTALALNHLVSTRFRSDELQIIAFGRYARTVTAGELTGLEGVYEQGTNLHHALALASRHLRRHPNAQPVVLVVTDGEPTAHLEDFGDGEGSSVFFDYPPHPRTIAHTVRGFDEVARLGAQVTIFRLGSDPGLARFIDQVARRVQGRVVVPDLDGLGAAVVGDYLHSRRR
>NZ_AP022565.1|WP_163668014.1|4801826_4802501_+|hypothetical-protein
MGVSKRVAGVVLLTSGLVLSGCTQMTDGTVTAGFGPPGGLSDATSGESGYKARTCEQLHSDAWIEVPGIGSDQPRVRVAQPPGWVPAPEFAKGPVKLVLRNESLSDGVTNPAVTVSIGDATDGNRSPEDLLSETIKGFQAVGAQNITQVPSEICGFPALMVNYTTPPDDQISKTSYVTAVSVMVPLGAKFWNIVALAQSTAPNNSTFMADAQVMLAGLRIALPR
>NZ_AP022565.1|WP_163668016.1|4802978_4804511_+|hypothetical-protein
MAVRPLVTTAAAVLSAGAIVAATPALFVPREQITVAAPTGAIAPATLTQEQINLLALSLQGAWQSFTQGYGGLWFPGQRPKPAEAFDTGGFLFDANGSELYNADGSRATTADLEPGAQYYYVNGKPDYELDAGGQIVLEDDPGNCAAPGAVCQKGFTGLAYYLSDNILPLGDVDNIFFEGGFTELAHQAIRTVALVIDAVDPTGRLDLTKRVDDFFEGGATQLVGNLLLDNLPQDGYAYGLTNSFFFGYGTNTGIYAAFTYVVDAIVQGTPTPNPNLINPLDSGPSTFSTQEQSSDTMLLAQKSTDPTSTGLPGPTSLLKLSTQSPLNNLVKLSFKTPAVDESNLVKNLDAIEQNVDQGIENPVEGGTGLIPVNIKLPTAPEPPTIETPKVPEVKAPDVKAPVLKLPEFKAPELKVPEVQVPEPKAPEVTAPESKPDITPKIRVKDKEPATEDEPATGTDTRNGNKVTPPILFGDGKPKGESNGSKFLKKLGEAVKNATESGKDAGSGDK
>NZ_AP022565.1|WP_163668018.1|4804888_4806406_+|hypothetical-protein
MAVRPLVTTGVALLSAGAIVAGTPALFVPRDEITVASSAAEAPAHRTLTAEQINLVALSLEGVLEAFNGGYGGHYYQGTVSLPTAGYVLNGNQLEDPKDDTPESTPLYGPDGKRLYLDTEGKTPATVGDMGDNVQFYNASGNKVNENYWDPGNCSASGAMCHDGFTGLAYYLSDNILPLDIVDNIFFEAGFSDGFAYLGSVIGTSIVDAFDPTQRLQLSKRVDEFFAGGAAYLAYSIINDNLPDDAVGEWAKGLNGTFYVDGILGVVDYMVETVKMLIAPDPEEANSTNLLSTHEETEAESESTSGVSSTSLPNVSKLLSLPTNVESPFKKLVEKLEAPADSKLVTTLDLKTDETKVDAIKVDETADDSAEAVVPIAEVAEAETPEVKAPKRPELKLPEIKLPQREIESVDADTNEAAASTESGTETKSRTETKAGTGTSLVRDSLVAKPEPKTTERKKSAGEKFVEKATKNLEKAFKPKTKAGADEKAKAKADSDSGDKDKNDK
>NZ_AP022565.1|WP_163668020.1|4806683_4807265_-|DUF1707-domain-containing-protein
MSTSAPQGKSMRATDTDRIQVAHLLTDAAAAGRLPMAEYEDRLAKAYAAQTYDDLARLSRDLPGAVNCSAGQCRPAPSTLLLAIMSGFERRGRWNVPKKLTTFALFGGGVVDLRYADFTAPDVDVRTYSIFGGQTILVPPEVNVDVDGVGVMGNFDQNVDGAGTSGAPRVHIRGFSLWGSVSVKRKKRRNQTD

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP022565_1	1.1\|1451000\|26\|NZ_AP022565\|CRISPRCasFinder	1451000-1451025	26	NZ_CP054029	Rhizobium sp. JKLM19E plasmid pPR19E02, complete sequence	434066-434091	4	0.846
NZ_AP022565_1	1.1\|1451000\|26\|NZ_AP022565\|CRISPRCasFinder	1451000-1451025	26	NC_012521	Rhodococcus opacus B4 plasmid pROB02, complete sequence	185490-185515	5	0.808
NZ_AP022565_1	1.1\|1451000\|26\|NZ_AP022565\|CRISPRCasFinder	1451000-1451025	26	NC_005073	Rhodococcus erythropolis linear plasmid pBD2, complete sequence	168587-168612	5	0.808

1. spacer 1.1|1451000|26|NZ_AP022565|CRISPRCasFinder matches to NZ_CP054029 (Rhizobium sp. JKLM19E plasmid pPR19E02, complete sequence) position: , mismatch: 4, identity: 0.846

gcaggccgccgacccgacaacaccgc	CRISPR spacer
gccttccgccgacccgagaacaccgc	Protospacer
**   ************ ********

2. spacer 1.1|1451000|26|NZ_AP022565|CRISPRCasFinder matches to NC_012521 (Rhodococcus opacus B4 plasmid pROB02, complete sequence) position: , mismatch: 5, identity: 0.808

gcaggccgccgacccgacaacaccgc	CRISPR spacer
acgggccgccgacccgacaacatcag	Protospacer
.*.*******************.*.

3. spacer 1.1|1451000|26|NZ_AP022565|CRISPRCasFinder matches to NC_005073 (Rhodococcus erythropolis linear plasmid pBD2, complete sequence) position: , mismatch: 5, identity: 0.808

gcaggccgccgacccgacaacaccgc	CRISPR spacer
acgggccgccgacccgacaacatcag	Protospacer
.*.*******************.*.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1051352 : 1058581

Tupanvirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_163661638.1\|1051352_1052981_-	ATP-binding cassette domain-containing protein	A0A2K9L0W2	Tupanvirus	1.8e-33	24.7
WP_163661640.1\|1052993_1053824_-	enoyl-CoA hydratase	NA	NA	NA	NA
WP_163661642.1\|1053842_1054217_-	thioredoxin	A0A1J0GW78	Streptomyces_phage	6.5e-11	37.6
WP_163661644.1\|1054453_1054591_-	hypothetical protein	NA	NA	NA	NA
WP_163669614.1\|1054675_1055599_-	hypothetical protein	A0A1P8DIG7	Virus_Rctr197k	1.2e-13	57.4
WP_163661646.1\|1055699_1056059_-	DUF59 domain-containing protein	NA	NA	NA	NA
WP_163661648.1\|1056055_1056544_-	SUF system NifU family Fe-S cluster assembly protein	A0A0K1LSF9	Mycobacterium_phage	2.0e-20	46.3
WP_163661650.1\|1056540_1057797_-	SufS family cysteine desulfurase	Q2XUY6	environmental_halophage	3.3e-99	44.8
WP_163661652.1\|1057798_1058581_-	Fe-S cluster assembly ATPase SufC	W8CYL7	Bacillus_phage	1.8e-07	27.7

DBSCAN-SWA_2

1684493 : 1692292

Lactococcus_phage(14.29%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_163662783.1\|1684493_1686662_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	V9VI16	Lactococcus_phage	1.1e-203	50.8
WP_163662786.1\|1686628_1687081_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A0N9RZU5	Staphylococcus_phage	3.9e-10	37.1
WP_163662789.1\|1687135_1687375_-	glutaredoxin-like protein NrdH	V5UN81	Mycobacterium_phage	3.0e-22	66.2
WP_163662792.1\|1687879_1688422_-	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	4.8e-07	35.3
WP_163662795.1\|1688511_1689129_+	TetR family transcriptional regulator	NA	NA	NA	NA
WP_163662798.1\|1689133_1690225_+	DNA polymerase IV	A0A218MNF2	uncultured_virus	1.0e-16	28.7
WP_163662801.1\|1690235_1691414_+	AAA family ATPase	A0A077SLJ9	Escherichia_phage	1.5e-61	37.6
WP_163662804.1\|1691410_1692292_-	SDR family oxidoreductase	W8CYX9	Bacillus_phage	1.2e-07	31.7

DBSCAN-SWA_3

4575456 : 4624755

Microbacterium_phage(11.11%)

protease,bacteriocin,tRNA,portal,integrase,terminase,capsid

attL 4587075:4587090|attR 4627180:4627195

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_163667494.1\|4575456_4576254_-\|bacteriocin	bacteriocin	NA	NA	NA	NA
WP_163667496.1\|4576250_4577261_-	Dyp-type peroxidase	NA	NA	NA	NA
WP_163667498.1\|4577311_4578577_+	M18 family aminopeptidase	NA	NA	NA	NA
WP_163670237.1\|4578653_4578968_-	hypothetical protein	NA	NA	NA	NA
WP_163667501.1\|4579416_4579764_+	VOC family protein	NA	NA	NA	NA
WP_163667504.1\|4579870_4582189_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.9e-270	62.1
WP_163667507.1\|4582185_4583913_+	alpha/beta-hydrolase family protein	NA	NA	NA	NA
WP_163667510.1\|4583912_4584566_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_163667512.1\|4584483_4585749_-	hypothetical protein	NA	NA	NA	NA
WP_163667515.1\|4585812_4587120_-	MCE family protein	NA	NA	NA	NA
WP_163667518.1\|4587036_4587423_+	hypothetical protein	NA	NA	NA	NA
4587075:4587090	attL	NA	NA	NA	NA
WP_170309461.1\|4587424_4588714_-	DoxX family protein	NA	NA	NA	NA
WP_163667521.1\|4588987_4590526_+	amidophosphoribosyltransferase	A0A1B1ISH6	uncultured_Mediterranean_phage	7.9e-47	30.3
WP_163667523.1\|4590665_4591757_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.2e-57	37.3
WP_163667526.1\|4591839_4592013_-	DUF3073 family protein	NA	NA	NA	NA
WP_163667529.1\|4592162_4593257_-	folate-binding protein YgfZ	NA	NA	NA	NA
WP_163667532.1\|4593323_4594202_+	aminodeoxychorismate lyase	NA	NA	NA	NA
WP_163667534.1\|4594474_4594726_-	hypothetical protein	NA	NA	NA	NA
WP_163667537.1\|4594725_4595409_-	FABP family protein	NA	NA	NA	NA
WP_163667540.1\|4595634_4595937_-	DUF1416 domain-containing protein	NA	NA	NA	NA
WP_163667543.1\|4595938_4596775_-	sulfurtransferase	NA	NA	NA	NA
WP_163667546.1\|4596822_4597305_-	DUF4395 family protein	NA	NA	NA	NA
WP_163667549.1\|4597514_4597937_-	thioredoxin family protein	NA	NA	NA	NA
WP_163667551.1\|4597933_4598749_-	mannan chain length control protein LmeA	NA	NA	NA	NA
WP_163670241.1\|4598884_4599706_+	winged helix-turn-helix domain-containing protein	W8CYM9	Bacillus_phage	1.5e-15	36.9
WP_163667554.1\|4599702_4600581_+	mycothiol synthase	NA	NA	NA	NA
WP_163667557.1\|4600702_4601842_+	phosphate ABC transporter substrate-binding protein PstS	NA	NA	NA	NA
WP_163667559.1\|4601896_4602952_+	phosphate ABC transporter permease subunit PstC	NA	NA	NA	NA
WP_163667562.1\|4602948_4603863_+	phosphate ABC transporter permease PstA	NA	NA	NA	NA
WP_163667565.1\|4603872_4604649_+	phosphate ABC transporter ATP-binding protein	A0A285PWH2	Cedratvirus	1.3e-08	27.5
WP_163667568.1\|4604673_4605339_-	phosphate signaling complex protein PhoU	NA	NA	NA	NA
WP_163667571.1\|4605425_4607618_-	LCP family protein	NA	NA	NA	NA
WP_163670243.1\|4607853_4608987_-\|tRNA	tRNA dihydrouridine synthase DusB	NA	NA	NA	NA
WP_163667574.1\|4609034_4610039_-	acyl-ACP desaturase	NA	NA	NA	NA
WP_163667577.1\|4610229_4610682_+	hypothetical protein	NA	NA	NA	NA
WP_163667579.1\|4610854_4611295_+	hypothetical protein	NA	NA	NA	NA
WP_163667582.1\|4611306_4611891_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_163667585.1\|4611970_4612981_+	DUF2236 domain-containing protein	NA	NA	NA	NA
WP_163667588.1\|4613022_4613379_-	DUF732 domain-containing protein	NA	NA	NA	NA
WP_163667591.1\|4613577_4613943_+	group 1 truncated hemoglobin	NA	NA	NA	NA
WP_163667594.1\|4614281_4614581_-	hypothetical protein	NA	NA	NA	NA
WP_163667596.1\|4614583_4615447_-\|capsid	phage major capsid protein	I3ULZ9	Rhodobacter_phage	6.9e-08	25.8
WP_163667599.1\|4615549_4616023_-	hypothetical protein	NA	NA	NA	NA
WP_163667602.1\|4616019_4616205_-	hypothetical protein	NA	NA	NA	NA
WP_163667605.1\|4616204_4617506_-\|portal	phage portal protein	U5P477	Mycobacterium_phage	4.7e-32	28.2
WP_163667608.1\|4617502_4618963_-\|terminase	terminase large subunit	A0A2K9VGS4	Pontimonas_phage	1.0e-51	32.5
WP_163667611.1\|4619366_4619702_-	hypothetical protein	NA	NA	NA	NA
WP_163667613.1\|4619698_4620250_-	hypothetical protein	NA	NA	NA	NA
WP_163667616.1\|4620246_4621620_-	AAA family ATPase	NA	NA	NA	NA
WP_163667619.1\|4621616_4621994_-	DUF2742 domain-containing protein	NA	NA	NA	NA
WP_163667622.1\|4621990_4622497_-	hypothetical protein	NA	NA	NA	NA
WP_163667624.1\|4622645_4622837_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_163667627.1\|4622957_4623596_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_163667630.1\|4623585_4624755_+\|integrase	tyrosine-type recombinase/integrase	G9FH48	Rhodococcus_phage	5.6e-77	42.0
4627180:4627195	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_AP022566

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CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_AP022565

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CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection