CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_AP022568	Mycobacterium simiae strain JCM 12377	4 crisprs	csa3,DinG,DEDDh,cas3,cas4,WYL,PD-DExK	0	2	1	0

1. NZ_AP022568

CRISPR-Cas detection and classification

Crispr_ID: NZ_AP022568_1

• CRISPR_ID: NZ_AP022568_1
• CRISPR_location: 306706-306828
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP022568_1

Consensus_repeat	Method
CATCACTTCGTTCTGCATCGTCGCGGCGCGACTCATTTGCGCCGCTT	CRISPRCasFinder

spacers of NZ_AP022568_1

>1.1|306753|29|NZ_AP022568|CRISPRCasFinder
CTCTCCCCCGCAAGCGGGAGGTACCCCCA

CRISPR arrays and Neighbor proteins around NZ_AP022568_1

CRISPR arrays

The CRISPR arrays of NZ_AP022568_1

>merge|NZ_AP022568|1|306706-306828|CRISPRCasFinder
CATCACTTCGTTCTGCATCGTCGCGGCGCGACTCATTTGCGCCGCTTCTCTCCCCCGCAAGCGGGAGGTACCCCCACATCACTTCGTTCTGCATCGTCGCGGCGCGACTCATTTGCGCCGCTT

>NZ_AP022568|1|1|306706-306828|CRISPRCasFinder
CATCACTTCGTTCTGCATCGTCGCGGCGCGACTCATTTGCGCCGCTT	CTCTCCCCCGCAAGCGGGAGGTACCCCCA
CATCACTTCGTTCTGCATCGTCGCGGCGCGACTCATTTGCGCCGCTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022568.1|WP_101528812.1|310699_312247_+|MFS-transporter	unknown	unknown	gnl|CDD|129794
NZ_AP022568.1|WP_044511358.1|308977_309253_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022568.1|WP_044511379.1|296863_298123_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223730
NZ_AP022568.1|WP_044511350.1|313997_315386_-|rRNA-small-subunit-methyltransferase-B	unknown	unknown	gnl|CDD|237857
NZ_AP022568.1|WP_044511366.1|305742_306213_-|PH-domain-containing-protein	unknown	unknown	gnl|CDD|371225
NZ_AP022568.1|WP_044511349.1|315382_316315_-|methionyl-tRNA-formyltransferase	unknown	unknown	gnl|CDD|234567
NZ_AP022568.1|WP_044511357.1|309249_309858_-|riboflavin-synthase	unknown	unknown	gnl|CDD|236455
NZ_AP022568.1|WP_044511364.1|306209_306689_-|6,7-dimethyl-8-ribityllumazine-synthase	unknown	unknown	gnl|CDD|234606
NZ_AP022568.1|WP_044511352.1|313269_313959_-|ribulose-phosphate-3-epimerase	unknown	unknown	gnl|CDD|235515
NZ_AP022568.1|WP_044511369.1|304677_305016_+|hemophore-related-protein	unknown	unknown	gnl|CDD|275322
NZ_AP022568.1|WP_044511360.1|308427_308790_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022568.1|WP_044511377.1|298127_299516_-|wax-ester/triacylglycerol-synthase-family-O-acyltransferase	unknown	unknown	gnl|CDD|274360
NZ_AP022568.1|WP_044511368.1|305023_305707_-|sensor-domain-containing-protein	unknown	unknown	unknown
NZ_AP022568.1|WP_044511376.1|300543_301620_-|uridine-diphosphate-N-acetylglucosamine-binding-protein-YvcK	unknown	unknown	gnl|CDD|211689
NZ_AP022568.1|WP_044513282.1|309989_310694_+|LppX_LprAFG-lipoprotein	unknown	unknown	gnl|CDD|369238
NZ_AP022568.1|WP_044511371.1|302521_304501_-|excinuclease-ABC-subunit-UvrC	unknown	unknown	gnl|CDD|234792
NZ_AP022568.1|WP_044513283.1|299569_300547_-|DNA-binding-protein-WhiA	unknown	unknown	gnl|CDD|273194
NZ_AP022568.1|WP_061559267.1|301616_302525_-|RNase-adapter-RapZ	unknown	unknown	gnl|CDD|224574
NZ_AP022568.1|WP_044511362.1|306846_308124_-|bifunctional-3,4-dihydroxy-2-butanone-4-phosphate-synthase/GTP-cyclohydrolase-II	unknown	unknown	gnl|CDD|181774
NZ_AP022568.1|WP_101528798.1|312247_313273_-|bifunctional-diaminohydroxyphosphoribosylaminopyrimidine-deaminase/5-amino-6-(5-phosphoribosylamino)uracil-reductase-RibD	unknown	unknown	gnl|CDD|273015

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP022568.1|WP_101528812.1|310699_312247_+|MFS-transporter	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.21714e-35
NZ_AP022568.1|WP_044511379.1|296863_298123_+|alpha/beta-hydrolase	gnl|CDD|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	5.15867e-44
NZ_AP022568.1|WP_044511350.1|313997_315386_-|rRNA-small-subunit-methyltransferase-B	gnl|CDD|237857	PRK14902, PRK14902, 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB.	4.5241e-92
NZ_AP022568.1|WP_044511366.1|305742_306213_-|PH-domain-containing-protein	gnl|CDD|371225	pfam10756, bPH_6, Bacterial PH domain. This domain has a bacterial type PH domain structure. This domain was previously known as DUF2581. This family is conserved in the Actinomycetales. Although several members are annotated as RbiX homologs, RbiX being a putative regulator of riboflavin biosynthesis, the function could not be confirmed.	1.66579e-19
NZ_AP022568.1|WP_044511349.1|315382_316315_-|methionyl-tRNA-formyltransferase	gnl|CDD|234567	PRK00005, fmt, methionyl-tRNA formyltransferase; Reviewed.	1.90392e-159
NZ_AP022568.1|WP_044511364.1|306209_306689_-|6,7-dimethyl-8-ribityllumazine-synthase	gnl|CDD|234606	PRK00061, ribH, 6,7-dimethyl-8-ribityllumazine synthase; Provisional.	1.08053e-63
NZ_AP022568.1|WP_044511352.1|313269_313959_-|ribulose-phosphate-3-epimerase	gnl|CDD|235515	PRK05581, PRK05581, ribulose-phosphate 3-epimerase; Validated.	5.51818e-135
NZ_AP022568.1|WP_044511369.1|304677_305016_+|hemophore-related-protein	gnl|CDD|275322	TIGR04529, hypothetical_protein, hemophore-related protein, Rv0203/Rv1174c family. Members of this family occur as paralogs in most Mycobacterium strains, including 2 in M. tuberculosis, 6 in M. avium, and 9 in M. smegmatis. Members have a cleaved N-terminal signal peptide and exactly two Cys residues in the mature protein, both at invariant positions. The best characterized member, Rv0203, is a hemophore, that is, a secreted polypeptide that binds heme and delivers it to a transport system for import. Hemophores are protein analogs of siderophores, natural products that chelate non-heme iron and deliver it to receptors for transport. The unrelated HasA family of hemophores has been described in Gram-negative bacteria such as Yersinia pestis and Pseudomonas aeruginosa. [Transport and binding proteins, Other].	1.00115e-13
NZ_AP022568.1|WP_044511357.1|309249_309858_-|riboflavin-synthase	gnl|CDD|236455	PRK09289, PRK09289, riboflavin synthase.	2.42115e-104
NZ_AP022568.1|WP_044511377.1|298127_299516_-|wax-ester/triacylglycerol-synthase-family-O-acyltransferase	gnl|CDD|274360	TIGR02946, Putative_diacyglycerol_O-acyltransferase_Mb3115, acyltransferase, WS/DGAT/MGAT. This bacteria-specific protein family includes a characterized, homodimeric, broad specificity acyltransferase from Acinetobacter sp. strain ADP1, active as wax ester synthase, as acyl coenzyme A:diacylglycerol acyltransferase, and as acyl-CoA:monoacylglycerol acyltransferase. [Unknown function, Enzymes of unknown specificity].	7.82975e-170
NZ_AP022568.1|WP_044511376.1|300543_301620_-|uridine-diphosphate-N-acetylglucosamine-binding-protein-YvcK	gnl|CDD|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	2.22298e-131
NZ_AP022568.1|WP_044513282.1|309989_310694_+|LppX_LprAFG-lipoprotein	gnl|CDD|369238	pfam07161, LppX_LprAFG, LppX_LprAFG lipoprotein. This entry consists of several lipoproteins mainly from Mycobacterium species, collectively known as the LppX_ LprAFG family. Proteins in this entry include LprG, LppX, LprF and lprA.	1.0619e-79
NZ_AP022568.1|WP_044511371.1|302521_304501_-|excinuclease-ABC-subunit-UvrC	gnl|CDD|234792	PRK00558, uvrC, excinuclease ABC subunit UvrC.	0
NZ_AP022568.1|WP_044513283.1|299569_300547_-|DNA-binding-protein-WhiA	gnl|CDD|273194	TIGR00647, DNA_bind_WhiA, DNA-binding protein WhiA. This family describes a DNA-binding protein widely conserved in Gram-positive bacteria, and occasionally occurring elsewhere, such as in Thermotoga. It is associated with cell division, and in sporulating organisms with sporulation. [Cellular processes, Cell division].	2.51928e-134
NZ_AP022568.1|WP_061559267.1|301616_302525_-|RNase-adapter-RapZ	gnl|CDD|224574	COG1660, COG1660, Predicted P-loop-containing kinase [General function prediction only].	1.52228e-162
NZ_AP022568.1|WP_044511362.1|306846_308124_-|bifunctional-3,4-dihydroxy-2-butanone-4-phosphate-synthase/GTP-cyclohydrolase-II	gnl|CDD|181774	PRK09311, PRK09311, bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II.	0
NZ_AP022568.1|WP_101528798.1|312247_313273_-|bifunctional-diaminohydroxyphosphoribosylaminopyrimidine-deaminase/5-amino-6-(5-phosphoribosylamino)uracil-reductase-RibD	gnl|CDD|273015	TIGR00326, eubact_ribD, riboflavin biosynthesis protein RibD. This model describes the ribD protein as found in Escherichia coli. The N-terminal domain includes the conserved zinc-binding site region captured in the model dCMP_cyt_deam and shared by proteins such as cytosine deaminase, mammalian apolipoprotein B mRNA editing protein, blasticidin-S deaminase, and Bacillus subtilis competence protein comEB. The C-terminal domain is homologous to the full length of yeast HTP reductase, a protein required for riboflavin biosynthesis. A number of archaeal proteins believed related to riboflavin biosynthesis contain only this C-terminal domain and are not found as full-length matches to this model. [Biosynthesis of cofactors, prosthetic groups, and carriers, Riboflavin, FMN, and FAD].	1.34322e-104

Protein sequences

>NZ_AP022568.1|WP_044511364.1|306209_306689_-|6,7-dimethyl-8-ribityllumazine-synthase
MSGAGIPDLGELDASGLRLGIVASTWHSTICDALLAGAERVVARSGVDNPTVVRVHGAIEIPVVAQELARNHDAVIALGVVIRGGTPHFEYVCDAVTQGLTRVSLDASTPVANGVLTTNTEEQALDRAGLPTSAEDKGAQAAGAALTAALALRDLRARS
>NZ_AP022568.1|WP_044511366.1|305742_306213_-|PH-domain-containing-protein
MTRPSAGADWDAELRPHWTPIFAYGAAFLIAGAHIAVGVVLKISSSGVVFQTADQVAIAVLGLVIAGVVLLFARPRLRVGKPGLSVRNLLGDRLLPWSEIVGVSFPAGSRWAHIDLPDDEYIPVMAIQAVDKDRAVAAMDTIRSLLVRYRPDLESS
>NZ_AP022568.1|WP_044511368.1|305023_305707_-|sensor-domain-containing-protein
MARHLWGIAASVLIAAALCGCTTSVSGRAVRAPGQSPSASPRSVSPAFAPIPARDLLLQDGDSTPLGPATAMPVGATYFTSVTPPECGAALLFKGSPLPPPRSADHAESSYQLAGPALYAESIDNYDKKLNPHEVVWKSFGAVSKCRAAAVGHSPQGDFQPMRLSHFTIASDGVLVWTMTRADWTCDYGLVVLTRTVLLASVCDAKSGFPMAEWASKRRAQLDSRTT
>NZ_AP022568.1|WP_044511369.1|304677_305016_+|hemophore-related-protein
MSKRPLAGLAVGVGCLALSLSAGIGVASATPDVGPMVNTTCTYDQAMRAVHAENPMAAQYLDQSPPNLQFLRQFMASTPDERLNLLKAIQNNPGADQAFPIFRQMMIDCKNY
>NZ_AP022568.1|WP_044511371.1|302521_304501_-|excinuclease-ABC-subunit-UvrC
MPDPATYRPAPGSIPVEPGVYRFRDAHGRVIYVGKAKSLRSRLTSYFADIANLHPRTRQMVTTAAKVEWTVVNTEVEALQLEYNWIKEFDPRFNVRYRDDKSYPVLAVTLNEEFPRLMVYRGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSHGVFKRHKQIDRPCLLGYIDKCSAPCIGRVSPEQHRQIVDDFCDFLSGKTDRFARELEQQMRAASDELDFERAARLRDDIGALKRAMEKQAVVFGDGTDADVVAFADDELEAAVQVFHVRGGRVRGQRGWVVEKPGDPGGSGEEQLVEQFLTQFYGEQAELGGAADEAANPVPREVLVPCLPSNAGELSSWLSGLRGSRVVLRVPRRGDKRALAETVQRNAKEALQQHKLKRAGDFNARSAALQNIQDALGLADAPLRIECVDISHVQGTDVVGSLVVFEDGLPRKSDYRHFGIREAAGQGRSDDVASIAEVTRRRFARHLTEQNDPNMLSPEGKSRRFAYPPNLYVVDGGAPQVNAASAVLEELGITDVAVIGLAKRLEEVWVPAEPDPVILPRNSEGLYLLQRVRDEAHRFAITYHRSKRSKRMTASALDAVPGLGEHRRKALVTHFGSIARLKEATVDQITAVPGIGVATATAVVEALRPQPAEQAEPPGQVEQSGASA
>NZ_AP022568.1|WP_061559267.1|301616_302525_-|RNase-adapter-RapZ
MTSRVGDSDQRRGPVAGIDVVLVTGLSGAGRGTAAKVLEDLGWYVADNLPPQLITRMVDFGLAAGSRITQLAVVMDVRSRGFTGDLDEVRNELATRNINPRVVFMEASDDMLVRRYEQNRRSHPLQGRQTLAEGIAAERRMLAPVRATADLIIDTSTLSVRGLRESIERAFGGDTDLSTSVTVESFGFKYGLPMDADMVMDVRFLPNPHWVDELRPLTGQHPAVADYVVGQPGAAEFLDAYHRLLALVVEGYRREGKRYMTVAIGCTGGKHRSVAIAEALMHRLQAEDELSVRVLHRDLGRE
>NZ_AP022568.1|WP_044511376.1|300543_301620_-|uridine-diphosphate-N-acetylglucosamine-binding-protein-YvcK
MSPPQSEGIVALGGGHGLYATLSAARRLTPYVTAVVTVADDGGSSGRLRSELDVVPPGDLRMALAALASDSPYGQLWATILQHRFGGSGALAGHPIGNLLLAGLSEVLADPVAALDELGRILGVKGRVLPMCPIALQIEADVSGLEADPRIFRSIRGQVAIATTPGKVRRVRLLPPDPPATRQAVDAIMAADLVVLGPGSWFTSVIPHVLVPELAAALQATAARRALVLNLVAEPGETAGFSVERHLHVLAQHAPGFTVHDIIIDADRVPSEREREQLRRTATLLRAEVHFADVARPGTPLHDPGKLAAALDGVRAGRAGPAAPSAKATAEIRVDGEAAPTAVNGPAGSGPRGDDAWR
>NZ_AP022568.1|WP_044513283.1|299569_300547_-|DNA-binding-protein-WhiA
MTTEVKDELSRLVVKSVSARRAEVTSLLRFAGGLHIVGGRVVVEAEVDLGNIARRLRKDIFDLYGYNAVVHVLSASGIRKSTRYVLRVANDGEALARQTGLLDMRGRPVRGLPAQVVGGSIADAEAAWRGAFLAHGSLTEPGRSSALEVSCPGPEAALALVGAARRLGVSAKAREVRGADRVVVRDGEAIGALLTRMGAQDSRLIWEERRMRREVRATANRLANFDDANLRRSARAAVAAAARVERALEILGDSVPDHLASAGKLRVEHRQASLEELGRLADPPMTKDAVAGRIRRLLSMADRKAKVDGIPDTESAVTPDLLEDA
>NZ_AP022568.1|WP_044511377.1|298127_299516_-|wax-ester/triacylglycerol-synthase-family-O-acyltransferase
MQRLSSVDAAFWSAETAGWHMHVGALAICDPTDAPEYSFQRLRQLLIERLPELPQLRWRVTGSPLGLDRPWFVEDEELDVDFHIRRIGVPAPGGRREVDELVGRLMSYKLDRSRPLWELWVIEGVKGGRVATLTKMHHAIVDGVSGAGLGEILLDVTPEPRPPQRETVGSLVGFKLPGLERRAIGALINVGVMTPFRIARLVEQTLRQQIAALGVRSRPPRYFDAPKTRFNAPVSPHRRITGTRVELARAKAVKDAFGVKLNDVVLALVAGAAREYLQARGELPAKPLIAQIPVSTRTDDSQSDVGNQISSMTASLATDIEDPAERLLAIYESTQSAKEMAKALSAHQIMGLTETTPPGLLQLAARAYTATGLSRNLAPINMVVSNVPGPPMPLYMAGAKVESLVPLGPPVMDVALNVTCFSYTDFLDFGFVTTPEAANDIEDMAKAVEPALVDLEKAAADG
>NZ_AP022568.1|WP_044511379.1|296863_298123_+|alpha/beta-hydrolase
MRRPKPRPLLRAAVEFLNAANGLRPLARKGYSTVLVFAFGWPTSEVPGVYFSASLLDMLRRARRGDFAGRRGKAALTLTAASWAILAVIRYRGVTTPGPVLEAGLREQLGPDYAEALTELPATTPQRRGRRNLPLSNTVARRRYVEKTNVVSYGPHGRANRADIWRRRDLPRDGKAPVLVQIPGGAWVIGMRRPQAYPLMSHLAARGWICVSIGYRVSPLHTWPDHIVDVKRALAWVKENIANYGGDPNFVAITGGSAGGHLSSLAALTPNDPAFQPGFEDADTSVVAAVPVYGRYDWFSTEGDGRREFVELLEKLVVKRKFATNRDVYVDASPIRRLRADAPPFFVLHGHDDSLIPVGEAREFVEELRAVSKSPVAYAELPSAQHAFDIFSSPRAHRSAEAVARFLSWVYATTYLRRD
>NZ_AP022568.1|WP_044511362.1|306846_308124_-|bifunctional-3,4-dihydroxy-2-butanone-4-phosphate-synthase/GTP-cyclohydrolase-II
MTRLDSVERAVADIAAGKAVVVIDDEERENEGDLIFAAEKATPEMVAFMVRYTSGYLCVPLDGAICDRLGLLPMYALNQDKHGTAYTVTVDARLGVGTGISASDRATTMRLLADPASIATDFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGAMAQTDELRVFADEHDLALITIADIIEWRRKHEKHIERIAEARIPTRHGEFRAIGYASIYEDVEHVALVRGDIAGPNGEGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMAMVAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGADTVDANLKLGLPADARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVSLPVRANAENIRYLMTKRDRMGHDLAGLDDFHESVHLPGEFGGAL
>NZ_AP022568.1|WP_044511360.1|308427_308790_-|hypothetical-protein
MSVERLAEAVYEDLAFEAVATLAGRKAEAQSRAVWSKEVNDTTLTIVEHSVRDHTSYELVGDDGRDVSLGRYSTYPAVTAAVSRWTHYIEAGGSVGRWLAHYAVDCAGGQVIQMPVRRTV
>NZ_AP022568.1|WP_044511358.1|308977_309253_-|hypothetical-protein
MRVTAVVAAATLMGIAMLAGRGIATADASEEKEACQLMDDPSGRDAGYQPVEYAFMVLRGKMSAGDARNVISLAAQDFCPNHIIDLPASWR
>NZ_AP022568.1|WP_044511357.1|309249_309858_-|riboflavin-synthase
MFTGIVEELGEVTGRDVLTDAARLTIRGPVVTADAGHGDSIAVNGVCLTVVELLADGRFTADVMAETLDRSNLGALDVGKRVNLERAAAVNSRLSGHIVQGHVDGTGHVLSRTPSEHWEVVRIEVPSSIARYVVEKGSITVDGISLTVSALGTEPRDWFEVSLIPTTRELTTLGHAPVGTKVNLEVDVIAKYVERLLTVRDQ
>NZ_AP022568.1|WP_044513282.1|309989_310694_+|LppX_LprAFG-lipoprotein
MQTRRRLTAVLASLTLTTAVLAGCSSGSKNNGGPLPDATTLVKQSADTTKTVKSVHLVLTTEGKIPGLPIKKLTGDLTTTPSTAASGNAQLSMAGSDIDANFVVYDSVLYATLTPNKWSDFGKASDVYDVSVLLSPDDGLGNVLANFTNAKAEDRETINGQTTIKISGNVAPDAVNKIIPSLSATQPMPATVWIQETGDHQLVQANLQKSQGNSVQVTLSDWGKPVTVTKPPVS
>NZ_AP022568.1|WP_101528812.1|310699_312247_+|MFS-transporter
MRAGRGIAISAGSLAVLLGALDAYVVVTIMRDIMSDVHIPINQLQRITWIITMYLLGYIAAMPLLGRASDRFGRKLVLQVSLALFIIGSVITALAGHWGDFHLLIAGRTVQGIASGALLPVTLALGADLWAQRNRASVLGGIGAAQELGSVLGPLYGIFIVWVFHQWQYVFWINVPLTLLAMVAIQFSLPSHQQVDEPEKVDVVGGVLLAIALGLAVIGLYNPQPDGKTILPSYGLPLVIGAAVVGVLFILWERFSRTRLIDPTGVHFRPFLSALGASVCAGAALMVTLVNVELFGQGVLQMDQTAAAGLLLWFLIALPIGAVLGGFIATRIGDRAMTFLGLLIAAYGYWLIHYWRQDVMSQHHDIFGVSLPLVHTDLLVAGLGLGLVIGPLTSAALRVVPSAQHGIASAAVVVARMTGMLIGVAALSAWGLYRFNQIIAGLSAKISPDATLFERVAAQATLYLKAFAMMYGDIFAATVVICVVGALLGLLLGSRKHHAEEPALPPQEAVALGER
>NZ_AP022568.1|WP_101528798.1|312247_313273_-|bifunctional-diaminohydroxyphosphoribosylaminopyrimidine-deaminase/5-amino-6-(5-phosphoribosylamino)uracil-reductase-RibD
MSGQPVESLDAAMRLAIEQSNQVKGRTYPNPPVGAVILDAGGQVVGVGGTEPTGGDHAEVLALRRAGSLAAGGTAVVTLEPCNHYGKTPPCVDALLAAGLATVVYAVTDPNEIAAGGAARLSAAGVTVQSGVLADDVARGPLREWLHKQRTGSPHVTWKYASSLDGRSAAADGTSQWISSEASRLDLHRRRAAADAIIVGTGTVLADDPALTARLPDGSLADKQPLRVVVGTSEISPEAKVLNDDSRTMVIRTRDPMEVLKALSDRTDILLEGGPTLAGAFLREGAIDRILTYVAPILLGGPVTAVDDVGVPTITRALRWRFDGADRLGPDLLLSLVPQSG
>NZ_AP022568.1|WP_044511352.1|313269_313959_-|ribulose-phosphate-3-epimerase
MAGSTGGPLIAPSILAADFARLADEAAAVNGADWLHVDVMDGHFVPNLTIGLPVVEALLAATPIPMDCHLMIDNPDRWAPPYAEAGAYNVTFHAEATDNPVGVARDIRAAGAKAGISVKPGTPLEPYLEILPQFDTLLIMSVEPGFGGQSFIPEVLSKVRTARKLVDAGELTILVEIDGGINADTIEQAAEAGVDCFVAGSAVYGAEDPEAAVKALRRQARAASPHLRQ
>NZ_AP022568.1|WP_044511350.1|313997_315386_-|rRNA-small-subunit-methyltransferase-B
MSPASNQRRPGPRRRKPLDPARAAAFQVLRAVSERGAYANLALPALLRERGISGRDAAFATELTYGTCRTRGLLDAVIGAAAGRAPESINPVLLDLLRMGTYQLLRTRVDAHAAVSTTVDQAGLEFDSARAGFVNAVLRTIAGRDEKSWLDELAPDPARDPIGHAAFVHAHPRWIAQALADALGVHATDLDAVLASDDERPQVHLAARPGVLSAAELADAVGGSVGRYSPYAVYLPSGDPGRLAPVRDGQALVQDEGSQLVARALTLAPVDRDTGRWLDLCAGPGGKTTLLAAVAAERGARVTAVEPSQARADLVTANTRGLDVDVRRVDGRESGLRPGFDRVLVDVPCTGLGALRRRPEARWRRQPSDVPALAKLQRELLAAAIALTRPGGVVLYSTCSPHLAETVGVVADALRRHPVSALDTRPLFEPAEAGDGPYVQLWPHRHGTDAMFAAALRREAGE
>NZ_AP022568.1|WP_044511349.1|315382_316315_-|methionyl-tRNA-formyltransferase
MRLVFAGTPEPALPALRRLIDSPRHDVVAVLTRPDAASGRRGKPEPSPVAREALDRGLPVLRPSRPNSPEFVAELAEFAPDCCPVVAYGALLRDELLAVPPRGWVNLHFSLLPAWRGAAPVQAAIAAGDPITGATTFQIEPSLDSGPVYGVVTETIQTTDTAGDLLERLAVSGAALLLATLDGIEDGTLTPQPQAADGVSIAPKITVEQARVRWDLPASVVERRIRAVTPNPGAWTMIGDLRVKVWPVQIDTEAPEPLPPGVIQVDRKCVRVGTGSEPVRLNKIQPPGKKLMDAVDWARGARLDPAARAS

Crispr_ID: NZ_AP022568_2

• CRISPR_ID: NZ_AP022568_2
• CRISPR_location: 587978-588081
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP022568_2

Consensus_repeat	Method
GCCGGCTCAGGGCCGGCTCAGGCTTCGGTCGCT	CRISPRCasFinder

spacers of NZ_AP022568_2

>2.1|588011|38|NZ_AP022568|CRISPRCasFinder
CTTCGGTCGCTCGAGCCGGATTGCGACCTGCAGCCTTC

CRISPR arrays and Neighbor proteins around NZ_AP022568_2

CRISPR arrays

The CRISPR arrays of NZ_AP022568_2

>merge|NZ_AP022568|2|587978-588081|CRISPRCasFinder
GCCGGCTCAGGGCCGGCTCAGGGCCGGCTCAGGCTTCGGTCGCTCGAGCCGGATTGCGACCTGCAGCCTTCGCCGGCTCAAGGCCGGCTCAGGCTTCGGTCGCT

>NZ_AP022568|2|2|587978-588081|CRISPRCasFinder
GCCGGCTCAGGGCCGGCTCAGGGCCGGCTCAGG	CTTCGGTCGCTCGAGCCGGATTGCGACCTGCAGCCTTC
GCCGGCTCAAGGCCGGCTCAGGCTTCGGTCGCT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022568.1|WP_101528237.1|595471_596701_-|glycosyltransferase-family-1-protein	unknown	unknown	gnl|CDD|340817
NZ_AP022568.1|WP_044510992.1|591293_592517_-|winged-helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|225755
NZ_AP022568.1|WP_044513183.1|597686_598016_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022568.1|WP_044510999.1|585180_586857_-|ribonuclease-J	unknown	unknown	gnl|CDD|223668
NZ_AP022568.1|WP_044510988.1|594725_595475_+|dienelactone-hydrolase-family-protein	unknown	unknown	gnl|CDD|366780
NZ_AP022568.1|WP_081662253.1|579119_579782_-|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	unknown	unknown	gnl|CDD|273139
NZ_AP022568.1|WP_044511005.1|577775_578603_-|PspA/IM30-family-protein	unknown	unknown	gnl|CDD|224755
NZ_AP022568.1|WP_044510998.1|586876_587779_-|4-hydroxy-tetrahydrodipicolinate-synthase	unknown	unknown	gnl|CDD|235107
NZ_AP022568.1|WP_044513193.1|579748_580285_+|amino-acid-N-acetyltransferase	unknown	unknown	gnl|CDD|236132
NZ_AP022568.1|WP_101528236.1|593357_593864_-|dihydrofolate-reductase	unknown	unknown	gnl|CDD|365932
NZ_AP022568.1|WP_044513185.1|592558_593257_-|DivIVA-domain-containing-protein	unknown	unknown	gnl|CDD|274008
NZ_AP022568.1|WP_044510989.1|593860_594661_-|thymidylate-synthase	unknown	unknown	gnl|CDD|234984
NZ_AP022568.1|WP_044510994.1|589917_591294_-|type-I-restriction-modification-system-subunit-M	unknown	unknown	gnl|CDD|280533
NZ_AP022568.1|WP_044513188.1|584311_585184_+|SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|272862
NZ_AP022568.1|WP_044511002.1|583161_583476_+|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl|CDD|224278
NZ_AP022568.1|WP_044511001.1|583472_584306_+|mycofactocin-coupled-SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|274889
NZ_AP022568.1|WP_101528235.1|580342_582883_-|DNA-translocase-FtsK	unknown	unknown	gnl|CDD|224588
NZ_AP022568.1|WP_044511004.1|578743_579061_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|238045
NZ_AP022568.1|WP_044510983.1|596775_597552_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|235975
NZ_AP022568.1|WP_044513186.1|588850_589912_-|restriction-endonuclease-subunit-S	unknown	unknown	gnl|CDD|341155

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP022568.1|WP_101528237.1|595471_596701_-|glycosyltransferase-family-1-protein	gnl|CDD|340817	cd03784, GT1_Gtf-like, UDP-glycosyltransferases and similar proteins. This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.	2.59549e-53
NZ_AP022568.1|WP_044510992.1|591293_592517_-|winged-helix-turn-helix-domain-containing-protein	gnl|CDD|225755	COG3214, COG3214, Uncharacterized protein conserved in bacteria [Function unknown].	5.87108e-105
NZ_AP022568.1|WP_044510999.1|585180_586857_-|ribonuclease-J	gnl|CDD|223668	COG0595, COG0595, mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair].	0
NZ_AP022568.1|WP_044510988.1|594725_595475_+|dienelactone-hydrolase-family-protein	gnl|CDD|366780	pfam01738, DLH, Dienelactone hydrolase family.	3.59059e-60
NZ_AP022568.1|WP_081662253.1|579119_579782_-|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	gnl|CDD|273139	TIGR00560, pgsA, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis].	8.41013e-34
NZ_AP022568.1|WP_044511005.1|577775_578603_-|PspA/IM30-family-protein	gnl|CDD|224755	COG1842, PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms].	1.06698e-38
NZ_AP022568.1|WP_044510998.1|586876_587779_-|4-hydroxy-tetrahydrodipicolinate-synthase	gnl|CDD|235107	PRK03170, PRK03170, dihydrodipicolinate synthase; Provisional.	1.42351e-143
NZ_AP022568.1|WP_044513193.1|579748_580285_+|amino-acid-N-acetyltransferase	gnl|CDD|236132	PRK07922, PRK07922, amino-acid N-acetyltransferase.	1.90731e-114
NZ_AP022568.1|WP_101528236.1|593357_593864_-|dihydrofolate-reductase	gnl|CDD|365932	pfam00186, DHFR_1, Dihydrofolate reductase.	5.33239e-64
NZ_AP022568.1|WP_044513185.1|592558_593257_-|DivIVA-domain-containing-protein	gnl|CDD|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	3.27817e-05
NZ_AP022568.1|WP_044510989.1|593860_594661_-|thymidylate-synthase	gnl|CDD|234984	PRK01827, thyA, thymidylate synthase; Reviewed.	0
NZ_AP022568.1|WP_044510994.1|589917_591294_-|type-I-restriction-modification-system-subunit-M	gnl|CDD|280533	pfam02384, N6_Mtase, N-6 DNA Methylase. Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.	2.40275e-133
NZ_AP022568.1|WP_044513188.1|584311_585184_+|SAM-dependent-methyltransferase	gnl|CDD|272862	TIGR00027, Hypothetical_protein_Rv0893c/MT0917/Mb0917c., methyltransferase, TIGR00027 family. This model represents a set of probable methyltransferases, about 300 amino acids long, with essentially full length homology. Members share an N-terminal region described by Pfam model pfam02409. Included are a paralogous family of 12 proteins in Mycobacterium tuberculosis, plus close homologs in related species, a family of 8 in the archaeon Methanosarcina acetivorans, and small numbers of members in other species, including plants. [Unknown function, Enzymes of unknown specificity].	2.48609e-77
NZ_AP022568.1|WP_044511002.1|583161_583476_+|antibiotic-biosynthesis-monooxygenase	gnl|CDD|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	3.12591e-26
NZ_AP022568.1|WP_044511001.1|583472_584306_+|mycofactocin-coupled-SDR-family-oxidoreductase	gnl|CDD|274889	TIGR03971, short-chain_dehydrogenase/reductase_SDR, SDR family mycofactocin-dependent oxidoreductase. Members of this protein subfamily are putative oxidoreductases belonging to the larger SDR family. All members occur in genomes that encode a cassette for the biosynthesis of mycofactocin, a proposed electron carrier of a novel redox pool. Characterized members of this family are described as NDMA-dependent, meaning that a blue aniline dye serving as an artificial electron acceptor is required for members of this family to cycle in vitro, since the bound NAD residue is not exchangeable. See EC 1.1.99.36. [Unknown function, Enzymes of unknown specificity].	1.06172e-139
NZ_AP022568.1|WP_101528235.1|580342_582883_-|DNA-translocase-FtsK	gnl|CDD|224588	COG1674, FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning].	0
NZ_AP022568.1|WP_044511004.1|578743_579061_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	6.01375e-09
NZ_AP022568.1|WP_044510983.1|596775_597552_-|SDR-family-oxidoreductase	gnl|CDD|235975	PRK07231, FabG-like, SDR family oxidoreductase.	6.84912e-125
NZ_AP022568.1|WP_044513186.1|588850_589912_-|restriction-endonuclease-subunit-S	gnl|CDD|341155	cd17266, RMtype1_S_Sau1132ORF3780P-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to Staphylococcus aureus subsp. aureus MSHR1132 S subunit (S.Sau1132ORF3780P) TRD2-CR2. Staphylococcus aureus subsp. aureus MSHR1132 S subunit (S.Sau1132ORF3780P) recognizes 5'... CAAGNNNNNRTC ... 3'. The RM system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. For example S.Sau1132ORF3780P-TRD1 recognizes CAAG/CTTG and S.Sau1132ORF3780P-TRD2 recognizes GAY/RTC. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	1.03636e-55

Protein sequences

>NZ_AP022568.1|WP_044510998.1|586876_587779_-|4-hydroxy-tetrahydrodipicolinate-synthase
MSSVGFDAPARLGTLLTAMATPFGADGSLDLAGAAKLANHLVDAGCDGLVVSGTTGESPTTTDNEKLELLRAVLETVGDRARVIAGAGTYDTAHSIKLAQASAAEGAHGLLVVTPYYSRPPQSGLIAHFTAVADATELPVLLYDIPPRSVVPIEPDTIRTLASHPNIVGIKDAKADLHSGGQIIAETGLAYYSGDDALNLPWLAMGATGFISVISHLAASQLRELLSAFSSGDIATARKINVAVAPLCNAMSRLGGVTLSKAGLRLQGLDVGDPRLPQVPATPEQIEALAADMRAASVLR
>NZ_AP022568.1|WP_044510999.1|585180_586857_-|ribonuclease-J
MDEALSPPGPLTAGGLRVTALGGISEIGRNMTVFEHLGRLLIIDCGVMFPTHDEPGVDLILPDLRHIEDRLDDIEALVLTHAHEDHIGAIPFLLKLRPDIPVVGSKFTLAMVAAKCREHRLKPVFVEVKEGQRTRHGVFECEYFAVNHSIPDALAIAVSTGAGTVLHTGDIKLDQLPLDGRPTDLPGMSRLGGTGVDLFLCDSTNAEIPGVGPSESEVGPTLHRLIRGADGRVIVACFASNVDRVQQIIDAAVALGRRVSFVGRSMVRNMGIARELGFLRVADSDLIDIGAAEMMPPERVVLITTGTQGEPMSALSRMSRGEHRSITLTAGDLVVLSSSLIPGNEEAVYGVIDALSKIGARVVTNSQARVHVSGHAYAGELLFLYNGVRPRNVMPVHGTWRMLRANAKLAASAGVPESSILLAENGVSVDLVGGRASIAGAVPVGKMFVDGLVTGDVGDITLGERLILSEGFVAVTVVLHRGTGRSATTPHLHSRGFSEDPKALEPVVRKVEEELEALHAANVTDPIRIAQGVRRTVGKWVGETYRRQPMIVPTVIEI
>NZ_AP022568.1|WP_044513188.1|584311_585184_+|SAM-dependent-methyltransferase
MARNPAAQTAFGPMVLAAVEQNEPPARRLVDDDLADLFLPAPLRWLVGVSRLTPMRRLMIRGSEWAGPGLWANLACRKRFITDKIAEARDDINAVVILGAGLDTRAYLLNRQIRIPVFEVDLPVNIARKAKTVRRVLGGPPLSVRLVALDFERDDLLTALAEHGYLPDYRAFFICEGVTQYLTEDGVRRTLDGLRAAAPGSRLVFTYVRRDFIDGTNRYGTRTLYRNVRQRKQLWHFGLEPDEVADFIGEYGWRLIEQAGPDELVARYVRPTGRKLKASQLEWSAYAQKI
>NZ_AP022568.1|WP_044511001.1|583472_584306_+|mycofactocin-coupled-SDR-family-oxidoreductase
MTKAGPSGPLTGKVALITGAARGQGRAHAVRLAADGAAIIAVDLCEQIASVPYPLATPEDLAATVKLVEDAGARILARQGDVRDRASLTDAVRAGLDEFGRLDIVVANAGIAPMQSGDDGWRDVIDVNLTGVYNTITAAIPTMVKQGTGGSIVLISSSAGLAGVGSADAGSVGYTAAKHGVVGLMRVYANLLAGQMIRVNSIHPSGVDTPMINNEFTREWLANMAAATDTRGAMGNAMPVEVLDAQDVANAVAWLVSDQARYITGVTLPVDAGYLNR
>NZ_AP022568.1|WP_044511002.1|583161_583476_+|antibiotic-biosynthesis-monooxygenase
MPVVVVATLTVKPESVDTVREILTTAVEEVHEEPGCQLYSVHQSGETFVFIEQWADEEALKVHSTAPAIGKLFAAAGDHLAGPPDIKTLQPIPAGDPDKGQLRK
>NZ_AP022568.1|WP_101528235.1|580342_582883_-|DNA-translocase-FtsK
MASKTAARSGTRTSRSKATSRTGVSRSARPAPRKRPGRPAKRRNRSVLVATGVTCGRALRATWLMAARGTGGAARSIGRARDIEPGHRRDGIALVLLALAVVVAASSWFNAARPVGAWVDAVLRTFLGAGVLALPAILGAVAVMLMRTEPNPEARPRLILGASMISLSLLGLRHLWSGSPGDPELRRRAAGFIGFAIGGPLSDGLTSWIAAPLLFIGALFGLLLLTGTTIRELPEVMRAMFHTRFVDDQYDDEYPDEYADDYDYAEDQPREDLSDGYYDDGVRDDEPRAWPSSGAPGTPVSLDEPPADETPTVPALKDGSGKNRRRGAKKQDTQVLDRVVEGPYHLPPLELLVAGDPPKKRSAANTQMAEAIGEVLTQFKVDAAVTGCTRGPTVTRYEVELGPGVKVEKITALQKNIAYAVATESVRMLAPIPGKSAVGIEVPNTDREMVRLADVLTAPSTRRDHHPLVIGLGKDIEGDFISANLAKMPHLLVAGSTGSGKSSFVNSMLISLLTRATPEEVRMILIDPKMVELTPYEGIPHLITPIITQPKKAAAALAWLVEEMEQRYQDMQASRVRHIDDFNEKVRSGAITAPLGSQREYRPYPYIVAIVDELADLMMTAPRDVEDAIVRITQKARAAGIHLVLATQRPSVDVVTGLIKTNVPSRLAFATSSLTDSRVILDQAGAEKLIGMGDGLFLPMGAGKPIRLQGAFITDEEIQAVVAACKDQAEPEYTEGVTTAKPTGERTDVDPDIGDDMDVFLQAVELVVSSQFGSTSMLQRKLRVGFAKAGRLMDLMETRGIVGPSEGSKAREVLIKPDELAGTLALIRGSGAGSAGADGGDDFPED
>NZ_AP022568.1|WP_044513193.1|579748_580285_+|amino-acid-N-acetyltransferase
MSILLPVTQSPPGNQTVVVRRARTSDVPSIKHLVDTYAGKILLEKALVTLYEAVQEFWVADLDGAVVGCGALHVFWSDLGEIRTVAVDPATTGHGVGHAIVTKLIEVARELQLERIFVLTFETEFFGKHGFTEIEGTPVTAEVFEEMCRSYDIGVAEFLDLSYVKPNILGNTRMLLKL
>NZ_AP022568.1|WP_081662253.1|579119_579782_-|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase
MGFGSRVTVLTSGAAALVNRYSDAVSGQPQTGPAAGRVSIANLANVLTLLRLVLVPIFLLALFAGGGHETVARIVAFVVFAVACITDRLDGLLARNYGMATEFGAFVDPIADKMLIGSALVGLSMLAELPWWVTVLILVREIGVTLLRLAVIRRGVIPASWGGKLKTFVQAVAIGLFVLPLSGSLLTAASVVMGAALVLTVVTGIDYVASTVREIRRTGT
>NZ_AP022568.1|WP_044511004.1|578743_579061_-|helix-turn-helix-transcriptional-regulator
MPPLVREVIGEVLRVARTSQGRTLREVSDTARVSLGYLSEVERGRKEASSELLNAICDALDVPLSTVLTDAGQRMATEERATSRAANIDASTKVVIPPVASLAVA
>NZ_AP022568.1|WP_044511005.1|577775_578603_-|PspA/IM30-family-protein
MANPFVKAWKYVMALFNAKIDEHADPKIQIQQAIEEAQRTHQALTQQAAQVIGNQRQLEMRLNRQLADIEKLQVNVRQALTLTDQATAAGDAAKATEYNNAAEAFAAQLVTAEQGVEDLKALHDQALQAAAQAKKAVEQNSMVLQQKIAERTKLLSQLEQAKMQEQVSASLRSMSEIAAPGNTPSLDEVRDKIERRYANAVGAAELAQGSVQGRMLEVQQASVQMAGHSRLEQIRASMRGEALPTGGAAAPGTTPATPAPAEGAGGQVAEKPFGQ
>NZ_AP022568.1|WP_044513186.1|588850_589912_-|restriction-endonuclease-subunit-S
MLGEYLDFSTGSGAPVRVSDGRFPVYGANGVIGFTARPNARGPLIVLGRVGSYCGSAHYCESDVWVTDNALVCRAKEPAETRYWYYALQTCRLNEYRAGSGQPLLNQGILRDVSVRTVPEGQRRRIAELLGAFDDKIAANHRVIAAAEHLMVALVETVGDRVPLSCLAEHSTALRQPGHFDDMVAHFSLAAFDDDAMPRLVRRSTVRSGKFLLSGPCVLFAKLNPRIPRIWNVTRLPTEMAVASTEFVVLTPAGADTGPDTSALWAALRQRDVVESLQQKVAGTSGSHQRVRRADLMAVAVRDVRRLTASTARTIAGLGALCHARRSESVRLSALRDAALPLLISGDVRLRAD
>NZ_AP022568.1|WP_044510994.1|589917_591294_-|type-I-restriction-modification-system-subunit-M
MTQSKELKATLWKAAEKLRGSLSASQYKDVILGLVFLKHISASTWNTLADNAGNDAIGRLVDAAMIEATAADHALGVAPGLYENLDQRRLGELVRLLDGVPVGQHPGDALGEVYEYFLGHFARAEGRRGGEFFTPPSVVRLMVEVLEPTGGRVYDPCCGSGGMFVQTEAFIAEHAGDSTNVRIYGQESIEQTWRMAKLNLAIRGIDNTGLARGDTLVEDLHAGLQMDYVMANPPFNIKDWARDENDRRWCFGVPPAGNANYGWIQHILAKLTPAGKAGVVMANGSMSSNASGEGAIRAQIVDADLVSCMVALPTQLFRSTSIPVCLWFFAKDKGRRAGQVLFVDARGFGYLVDRTERVLTDAEVGHIADTYHAWCGTASAKGIEYQDVAGYCQSVSRDDIAAAGYLLTPGRYVGTPVAEDDAEPAAAKITRLTKDLLRALDESARLETAVREQVQRLC
>NZ_AP022568.1|WP_044510992.1|591293_592517_-|winged-helix-turn-helix-domain-containing-protein
MSTPTLTVAQARRIAVAAQGFNQPRPGGPVNRAHLRRLISRIQVLQLDSVSVSVRAHYAPVFSRLGPYDRDVLDRAAWGPRSARLLAEYWAHEAALIAVDDWPLLRWRMRQYRHGRWGTHIVKANPHLADKIVAAVSELGPSTAGQIEAHLEAESRGPRGSWWGSRSDTKWVAEALFASGVLTTATRVGFARHYDLVERVLPASVLARQVDDAEAVRELVLRAATALGVGTEPDIRDYFRLSPRQVKPALADLVAAGEIEAVTVDGWPGPAYLRAGQSTPRQDRGTALLCPFDPLIFFRPRVERLFGFHYRIEIYVPARQRKYGYYVWPVLVDGQLRARVDLKADRIADRLRVVGAFAEPEAPRPKVADALAGELASMASWLGLGGVSVSGRGDLAADLRAAVKRLG
>NZ_AP022568.1|WP_044513185.1|592558_593257_-|DivIVA-domain-containing-protein
MMTEPTKAFNRKFMGYEPAAVDAHIDMLTAKQKLLVDDVDSLRARLQNSADEVAALRKEVALLTDTSPTPHAMQQRMAKMLRSTVDEISEMQAEARAEAEAMITAAEAEIEAERRQHEQRLADMASRHKAMETEYREAKEALEAELAGMHDDARRAREQLLAEAKEQLDREREEARRAIAAAREQRVKVLEQLLAVHRDLDSVPAALEAAYREQEEPLQDGAAAVDEKVSAG
>NZ_AP022568.1|WP_101528236.1|593357_593864_-|dihydrofolate-reductase
MREVGLVWAQSTSGVIGRNGDIPWHVPEDLARFKQVTVGRTVIMGRRTWDSLPARVRPLPGRRNIVLSRQADFTADGAEVARSLDAAFASLSAPASESPAWVIGGAQIYAQALPLATRCEVTEIEVDLVRDDEDALAPVLDEAWLGETGEWHVSRSGLRYRFHSYRRA
>NZ_AP022568.1|WP_044510989.1|593860_594661_-|thymidylate-synthase
MPIPTPYEDLLRLVLATGSAKADRTGTGTRSLFGQQLRYDLSAGFPLLTTKKVHLKSVVYELLWFLRGDSNVGWLHEHGVTIWDEWASDTGDLGPIYGVQWRSWPTPSGDHIDQISAALELLRTDPNSRRNIVSAWNVGEIPQMALPPCHAFFQFYVADRRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLDVGEFIWTGGDCHIYDNHVDQVRIQLSREPRPYPELFLAHRDSIFDYTYEDVVVKNYDPHPAIKAPVAV
>NZ_AP022568.1|WP_044510988.1|594725_595475_+|dienelactone-hydrolase-family-protein
MPNIIDTVTTADGSCTVHLLTPNGHEARVPWPGVVMYPDAGGLRDTFQHMAAKLASYGYTVLLPDVYYRSGDWAPFDMATVFGDESERKRLFAMIGTLTPDKVASDARAFFNYLADRPEVSGERFGVCGYCMGGRISLLVAGRVPDRVAAAASFHGGGLVTDAADSPHLLAHRMTATIYVGGAQNDASFTTDDAEQLDKALTAAQVPHTIEWYQAGHGFAVPDNAPYDEAAAERHWAAMTEVFAAALPR
>NZ_AP022568.1|WP_101528237.1|595471_596701_-|glycosyltransferase-family-1-protein
MRVLLSTYDSRGGVEPLLALAVQLQALGAQAVLACPPDDEFAERAAGFGIPLVAFGPSVRAVTTAATRSSEEQLRTHVLGLIDAQFDTVAAAAQGCDALVSTALVWTAAGARSVADKLGIHYVYASYHPTHLPSPYHPPPEYVGRGMGTSEIDNRVMWDHNARNANALFGPTLNSRRASIGLPPVSDVRGYAYTDRPWLAADPTLGPWQRLPGFDVMQTGAWLLPDDRPLSAELEEFLDAGPPPVYLGFGSMPLWGAKEVVPMAIAAIRAQGRRVLLARGWADLAPDGDADDCFAIGEVNQQALFRRVAAVVHHGGAGTTTTAARAGVPQVVVPQGPDQVYWALRVIALGIGSACDGPTPPVGALPAALEVALADETRARADAVGRDIAADGAAVAAKLLLEAVSGEKL
>NZ_AP022568.1|WP_044510983.1|596775_597552_-|SDR-family-oxidoreductase
MTTLDLTGRTAIITGASRGIGLAISQQLAAAGANVVLTARKQEAADAAAAQVGEAAVGVGAHAVDEDAARRCVDLTLERFGSVDILINNAGTNPAFGPLIEQDHARFSKIFDVNLWAPLLWTSLVVKAWMGEHGGAIVNTASIGGLHQSPGMGMYNATKAALIHVTKQLALELSPRIRVNAIAPGVVRTRLAEALWKDNEDPLGASIALGRIGEPIDVANAVTFLVSDAASWITGETMVIDGGLLLGGAQGFQMRPQS
>NZ_AP022568.1|WP_044513183.1|597686_598016_+|hypothetical-protein
MKPLVVGGAVAAAIAAAPIAAADSFATSPAMTGPAPTHIVFKDDPGGGGCDANGNCGSGGQNNGPGGGPGGQGCVPGVGCGSGGQFAGPGGVPGGTGCLPGVGCGSGHA

Crispr_ID: NZ_AP022568_3

• CRISPR_ID: NZ_AP022568_3
• CRISPR_location: 2654050-2654156
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP022568_3

Consensus_repeat	Method
TTGATGCCAGCCGGGGTCGAGGAGTTGCGCCCGTGACCC	CRISPRCasFinder

spacers of NZ_AP022568_3

>3.1|2654089|29|NZ_AP022568|CRISPRCasFinder
GCGCACACGACGAAGAGGCCGGCTTGGCG

CRISPR arrays and Neighbor proteins around NZ_AP022568_3

CRISPR arrays

The CRISPR arrays of NZ_AP022568_3

>merge|NZ_AP022568|3|2654050-2654156|CRISPRCasFinder
TTGATGCCAGCCGGGGTCGAGGAGTTGCGCCCGTGACCCGCGCACACGACGAAGAGGCCGGCTTGGCGTTGATGCCAGCCGGGGTCGAGGAGTTGCGCCCGTGACCC

>NZ_AP022568|3|3|2654050-2654156|CRISPRCasFinder
TTGATGCCAGCCGGGGTCGAGGAGTTGCGCCCGTGACCC	GCGCACACGACGAAGAGGCCGGCTTGGCG
TTGATGCCAGCCGGGGTCGAGGAGTTGCGCCCGTGACCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022568.1|WP_044509098.1|2659863_2661735_+|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP022568.1|WP_101528341.1|2643553_2644309_+|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293807
NZ_AP022568.1|WP_044509095.1|2663319_2663601_+|cell-division-protein-CrgA	unknown	unknown	gnl|CDD|178907
NZ_AP022568.1|WP_049919070.1|2641853_2642531_-|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|380065
NZ_AP022568.1|WP_081662366.1|2648208_2648466_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022568.1|WP_044509105.1|2651785_2653441_+|DUF3662-and-FHA-domain-containing-protein	unknown	unknown	gnl|CDD|378850
NZ_AP022568.1|WP_044509096.1|2662457_2663201_-|DUF881-domain-containing-protein	unknown	unknown	gnl|CDD|226396
NZ_AP022568.1|WP_044509094.1|2663756_2664191_+|PH-domain-containing-protein	unknown	unknown	gnl|CDD|371225
NZ_AP022568.1|WP_044509097.1|2661712_2662408_-|aminodeoxychorismate/anthranilate-synthase-component-II	unknown	unknown	gnl|CDD|181107
NZ_AP022568.1|WP_101528340.1|2658535_2659867_+|serine/threonine-protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP022568.1|WP_044509102.1|2655654_2657064_+|FtsW/RodA/SpoVE-family-cell-cycle-protein	unknown	unknown	gnl|CDD|279444
NZ_AP022568.1|WP_044509093.1|2664903_2665341_+|cell-wall-synthesis-protein-CwsA	unknown	unknown	gnl|CDD|313910
NZ_AP022568.1|WP_155945919.1|2641280_2641613_-|hypothetical-protein	unknown	unknown	gnl|CDD|226607
NZ_AP022568.1|WP_044509107.1|2644347_2645706_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|235337
NZ_AP022568.1|WP_044509101.1|2657060_2658539_+|D,D-transpeptidase-PbpA	unknown	unknown	gnl|CDD|223839
NZ_AP022568.1|WP_044509108.1|2642527_2643460_-|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl|CDD|376566
NZ_AP022568.1|WP_044509109.1|2640266_2641154_-|hypothetical-protein	unknown	unknown	gnl|CDD|214936
NZ_AP022568.1|WP_044509104.1|2653549_2654017_+|growth/cell-division-associated-protein-FhaB	unknown	unknown	gnl|CDD|224630
NZ_AP022568.1|WP_049919067.1|2650499_2651372_-|hypothetical-protein	unknown	unknown	gnl|CDD|376279
NZ_AP022568.1|WP_044512578.1|2664217_2664766_-|peptidylprolyl-isomerase	unknown	unknown	gnl|CDD|223725

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP022568.1|WP_044509098.1|2659863_2661735_+|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.33769e-127
NZ_AP022568.1|WP_101528341.1|2643553_2644309_+|MBL-fold-metallo-hydrolase	gnl|CDD|293807	cd07721, yflN-like_MBL-fold, uncharacterized subgroup which includes Bacillus subtilis yflN; MBL-fold metallo hydrolase domain. This subgroup includes the uncharacterized Bacillus subtilis yflN protein. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	1.52364e-40
NZ_AP022568.1|WP_044509095.1|2663319_2663601_+|cell-division-protein-CrgA	gnl|CDD|178907	PRK00159, PRK00159, putative septation inhibitor protein; Reviewed.	4.12477e-47
NZ_AP022568.1|WP_049919070.1|2641853_2642531_-|TetR-family-transcriptional-regulator	gnl|CDD|380065	pfam17939, TetR_C_30, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in the Pseudomonas aeruginosa PsrA which regulates the fadBA5 beta-oxidation operon. Functional analysis of PsrA indicated its importance in regulating b-oxidative enzymes. It has also been suggested that PsrA, a member of the TetR family of repressors, could affect global gene expression including activation of rpoS.	6.88538e-13
NZ_AP022568.1|WP_044509102.1|2655654_2657064_+|FtsW/RodA/SpoVE-family-cell-cycle-protein	gnl|CDD|279444	pfam01098, FTSW_RODA_SPOVE, Cell cycle protein. This entry includes the following members; FtsW, RodA, SpoVE.	5.95873e-104
NZ_AP022568.1|WP_044509105.1|2651785_2653441_+|DUF3662-and-FHA-domain-containing-protein	gnl|CDD|378850	pfam12401, DUF3662, Protein of unknown function (DUF2662). This domain family is found in bacteria, and is approximately 120 amino acids in length. The family is found in association with pfam00498.	3.98889e-48
NZ_AP022568.1|WP_044509096.1|2662457_2663201_-|DUF881-domain-containing-protein	gnl|CDD|226396	COG3879, COG3879, Uncharacterized protein conserved in bacteria [Function unknown].	8.68074e-72
NZ_AP022568.1|WP_044509094.1|2663756_2664191_+|PH-domain-containing-protein	gnl|CDD|371225	pfam10756, bPH_6, Bacterial PH domain. This domain has a bacterial type PH domain structure. This domain was previously known as DUF2581. This family is conserved in the Actinomycetales. Although several members are annotated as RbiX homologs, RbiX being a putative regulator of riboflavin biosynthesis, the function could not be confirmed.	2.02022e-15
NZ_AP022568.1|WP_044509097.1|2661712_2662408_-|aminodeoxychorismate/anthranilate-synthase-component-II	gnl|CDD|181107	PRK07765, PRK07765, aminodeoxychorismate/anthranilate synthase component II.	1.09866e-152
NZ_AP022568.1|WP_101528340.1|2658535_2659867_+|serine/threonine-protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.76471e-117
NZ_AP022568.1|WP_044509093.1|2664903_2665341_+|cell-wall-synthesis-protein-CwsA	gnl|CDD|313910	pfam10814, CwsA, Cell wall synthesis protein CwsA. Cell wall synthesis protein CwsA is required for cell division, cell wall synthesis and cell shape maintenance.	8.28837e-52
NZ_AP022568.1|WP_155945919.1|2641280_2641613_-|hypothetical-protein	gnl|CDD|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	3.09637e-13
NZ_AP022568.1|WP_044509107.1|2644347_2645706_+|alpha/beta-hydrolase	gnl|CDD|235337	PRK05077, frsA, esterase FrsA.	1.09257e-13
NZ_AP022568.1|WP_044509109.1|2640266_2641154_-|hypothetical-protein	gnl|CDD|214936	smart00956, RQC, This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure. The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain.	0.00418588
NZ_AP022568.1|WP_044509108.1|2642527_2643460_-|fumarylacetoacetate-hydrolase-family-protein	gnl|CDD|376566	pfam01557, FAA_hydrolase, Fumarylacetoacetate (FAA) hydrolase family. This family consists of fumarylacetoacetate (FAA) hydrolase, or fumarylacetoacetate hydrolase (FAH) and it also includes HHDD isomerase/OPET decarboxylase from E. coli strain W. FAA is the last enzyme in the tyrosine catabolic pathway, it hydrolyzes fumarylacetoacetate into fumarate and acetoacetate which then join the citric acid cycle. Mutations in FAA cause type I tyrosinemia in humans this is an inherited disorder mainly affecting the liver leading to liver cirrhosis, hepatocellular carcinoma, renal tubular damages and neurologic crises amongst other symptoms. The enzymatic defect causes the toxic accumulation of phenylalanine/tyrosine catabolites. The E. coli W enzyme HHDD isomerase/OPET decarboxylase contains two copies of this domain and functions in fourth and fifth steps of the homoprotocatechuate pathway; here it decarboxylates OPET to HHDD and isomerises this to OHED. The final products of this pathway are pyruvic acid and succinic semialdehyde. This family also includes various hydratases and 4-oxalocrotonate decarboxylases which are involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. 2-hydroxypentadienoic acid hydratase encoded by mhpD in E. coli is involved in the phenylpropionic acid pathway of E. coli and catalyzes the conversion of 2-hydroxy pentadienoate to 4-hydroxy-2-keto-pentanoate and uses a Mn2+ co-factor. OHED hydratase encoded by hpcG in E. coli is involved in the homoprotocatechuic acid (HPC) catabolism. XylI in P. putida is a 4-Oxalocrotonate decarboxylase.	1.13354e-52
NZ_AP022568.1|WP_044509101.1|2657060_2658539_+|D,D-transpeptidase-PbpA	gnl|CDD|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	7.63559e-109
NZ_AP022568.1|WP_044509104.1|2653549_2654017_+|growth/cell-division-associated-protein-FhaB	gnl|CDD|224630	COG1716, COG1716, FOG: FHA domain [Signal transduction mechanisms].	5.7536e-32
NZ_AP022568.1|WP_049919067.1|2650499_2651372_-|hypothetical-protein	gnl|CDD|376279	pfam18860, AbiJ_NTD3, AbiJ N-terminal domain 3. Alpha + beta domain. Found fused to AbiJ-like HEPN. Fused to other domains presumably involved in defense.	5.57741e-50
NZ_AP022568.1|WP_044512578.1|2664217_2664766_-|peptidylprolyl-isomerase	gnl|CDD|223725	COG0652, PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones].	1.37613e-65

Protein sequences

>NZ_AP022568.1|WP_044509104.1|2653549_2654017_+|growth/cell-division-associated-protein-FhaB
MQGLVLQLTRAGFLMLLWVFIWSVLRILKTDIYAPTGAVMVRRGLALRGSLLSSRQRRHAARYLVVTEGALAGARITLSGQPVLIGRADDSTLVLTDDYASTRHARLSQRGSEWYVEDLGSTNGTYLDRAKVTTAARVPIGTPIRIGKTAIELRP
>NZ_AP022568.1|WP_044509105.1|2651785_2653441_+|DUF3662-and-FHA-domain-containing-protein
MGSQKGLAARIERKLESTVGDAFARVFGGSIVPQEIEALLRREAEDGVRPLHGNRLLAPNEYVITLGVHDFERVAADPDLTSGAFARYLADYLQEQGWETYGDVVVRFEQLPNLHTGQFRARGAVNPDVEPRPTVNDPVRPQSNQAFSAEPGVPPMTDNSSYRGGQGQGRPGDEYYARPQDDQRGGQDPQAGADQRGGYPQEQGGHPPQGGYQPPRYPDQGQGGYQDQRGGYPEQGGYQEQRGGYPEQGGYPPQGGYPGPGGYPDQGRGYPEQGQGGYPPPYEPPYEHRPPAGGYGAPGYDHGGQGYDQGGQAYDQSYRPGGGYAPPPAGQPGAGQQGYGGYGGDYGRGPARPEETGYAAPPAPEQRPSYPEQGGYDQGYQQGAPSYGQQEYAGGDYTQYAENVPVGGYGPQGGGYPETAHRDYEYGQQPEYGQPADYGQQAGGYGGYGQGGYGAAGAAVTLQLDDGSGRTYQLREGSNIVGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLSDLNSTNGTTVNNAPVQEWQLADGDVIRLGHSEIIVRIH
>NZ_AP022568.1|WP_049919067.1|2650499_2651372_-|hypothetical-protein
MLAADATFIAIGDTVSLIPIILEGHPIHRVGCRPQRSCRGVATKRITQVTLRRIFDTINLSKVLLEGRLEEPDFLARIHDLDSMSSTASRYKSAAGDIWQHRVNNPQDWPDDSVGTDSRFGLQHGDDEFALRFLAEMLHPVVRPDEEEVAGLLKSFNEALARDGCELYAADWISGHAVYGWRRRDSFLDLRPNGLVGRVVTGVDDNGEIVTEEFEHSSGEVITEGTTFTDGYGENPTQRAQFIVSVIRIHLARQTCRHHRADVAALRDVLGEQVRWCPSCGAHLGPGAAT
>NZ_AP022568.1|WP_081662366.1|2648208_2648466_+|hypothetical-protein
MGTVLDAVAPEHRDVIVEELSHRDPALLADLRDATEPTLEQREGVNRALADAVVWSLGPDYSPNDHGLAVERAVKAFLEAWPIHR
>NZ_AP022568.1|WP_044509107.1|2644347_2645706_+|alpha/beta-hydrolase
MTEASLPQKLFVTACAVTRTTDLAARWTGAAPFLPALFVLRYANMGGLDHTLFAAQIRGARSFRDDRWCGYWNRIADTHARRARNVLRSLAGTDAASVPDLTDPSAATAAENVDGLTAWIAPAAALFADHGPQPDTRALTALVDEHAPAGDRERITLAFSAIDAWVKAITYYQVSAFPGHDPHRMKAYWRSRHLFDALIGALVPTLGLTVEHVDIPLTDGDTVGGYLVLPPGSGPHPVVLTTNGLEGTAQELAIPQLRYRDTGMAMFLMEMPGSYAYTHPMQPESEAVYHRIIEHLAHDQRLDADRIAMVGVSFGGYWTARLAATNDRLACAIACGAPTHRSFHGGALGTPQIILHALAKTVGAAHPIDLVRKLKALSIRDLYSRITMPLLVINGDHDTLMSTQDSSDLAHAAANATLLLYPDDDHCAMGHYRQWLDYSQHWLMEHIPVTAN
>NZ_AP022568.1|WP_101528341.1|2643553_2644309_+|MBL-fold-metallo-hydrolase
MGVQEVAEGVFCVAGTAVNWVLLRDGADLTLIDAGWSGDTGRVENSIRALGRHPMDVQAILLTHAHLDHMGAINHFHRRYDTPVFMSGAEVVHARDGHLEQATPADIIERCYRPSALRWTARIMAAGALKPVKLPHAQPFPGAGALDLPGAPVPVACAGHTCGHSAFHLPDKGVLVTGDALVTGHPLSPVSGPQLVPPFFAHAPADADAALQTLTGIAADILVPGHGDPWRGTPSDAAEQARRNARTTNRL
>NZ_AP022568.1|WP_044509108.1|2642527_2643460_-|fumarylacetoacetate-hydrolase-family-protein
MKLRRVRTVEGLQLQTFGADGSWQASTDPTPLGGRVFDRDWELARIDEHRQHSAVLLPFQPVSFRDFMLYEQHVLDASRGLVRRFHPGQYRLVETVELLTRRTFPLLKPKPLFYAQPMYYMSNAMTFIPSRTPITAPSYSQALDYELEIGFVLARGLFNATPAEALDAIGAFVVLNDWSARDVQRAEMDSGFGPQKAKHFASSLSEVAVTADEILPRIDALRGTVSINGSIVSTVSSAGMQHDLGEVLAHASRSEHLYPGELFGTGTLPGGSGMETGHWLGPGDTLELTIDDIGYIEHTVTTPSTRGIDS
>NZ_AP022568.1|WP_049919070.1|2641853_2642531_-|TetR-family-transcriptional-regulator
MTSPAAADPPPPASREANREKLRDRLLDSAEELFADRGYFGVSVRDITDHAGTRLAAVSDQFGGKEALFRAVLLRRIQPLNDDRRTRLAAVPPRGTRAQRLRALIGAFTEPMRQRAGDPGWDNYFRFIAQLANSAHPIGRFIVEDFNAIAADFIAALQTLFPATDEAAIHDAYLHLLAATLHTYSNNLRLDSLTDGRMHTGDIDERHQALLRFAEGGITALATTP
>NZ_AP022568.1|WP_155945919.1|2641280_2641613_-|hypothetical-protein
MSAERAQANLTDAGLADVVDIRIGDALETLRDGIEDGIDLVLLDGAWSLYLPVLQILESRLAPGALVIAENAVDESGDYLTYVRNPDNGYRSLPLPFEPGRGNEMSVYTA
>NZ_AP022568.1|WP_044509109.1|2640266_2641154_-|hypothetical-protein
MRRQPELARRFFDRFEPVHAVTYFAPEARAAFDQLGYRGFWMGYFAARSAPLGPVAPEVVTAVFYNFAPQRVAKALPAAWQIAGPEAALRARLDSAVATLRRYGLKEDENVCTAAELAAKAARRAPADGRALFAANRALPWPDDPLAALWHATTLLREQRGDGHVAVLTAAGISGRECNVLHAAANRVPREYIARTRDYDDDEWHRIERQLGARGLLGEDGSLTAAGRALKEQVESSTDALALSALEPLSDDEVEALFQALTPITRAVVEGGDVLAVTPMALRRDELHDTSAHLA
>NZ_AP022568.1|WP_044509102.1|2655654_2657064_+|FtsW/RodA/SpoVE-family-cell-cycle-protein
MTTQVQPPVAVTPPLPTRRNSELLLLCFAALITVAALLIVEANQGRGLRLDLVGYGLIFLAVFGSAHVAVRRFAPYADPLLLPIVALLNGLGLVMIHRLDLVGGELSGRHHPSATQQLLWTLVSVAAFALVVTFLKDHRQLARYGYIFGLTGLVFLAIPAILPASLSEQNGAKIWIRLPGFSIQPAEFSKILLLIFFSAVLVAKRGLFTSVGKHLMGMTLPRPRDLAPLLAAWVISIGVMVFEKDLGTSLLLYASFLVVVYLATQRFSWVVIGLVLFAAGSVVAYFIFAHVRVRVQMWWDPFSDPDGNGYQSVQSLFSFATGGIFGTGLGNGQPDTVPAASTDFIIAAFGEELGLVGLASILMLYTIVIVRGLRTAIATRDSFGKLLAAGLASTLAIQLFIVVGGVTQLIPLTGLTTPWMSYGGSSLLANYVLLGILARISHSARRPLRTPRRDTAPIAAAGTEVIERV
>NZ_AP022568.1|WP_044509101.1|2657060_2658539_+|D,D-transpeptidase-PbpA
MNASLRRISVTVMALIVLLLLNATMTQVFAADGLRADPRNQRVLLDEYSRQRGQIIAGGQLLAYSVATDSHFRFLRVYPNPAVYAPVTGFYSLRYSSSGLERAEDSLLNGSDVRLFGRRLADFFTGRDPRGGNVDTTINPRVQQAGWDAMQQGCGGPPCKGAVVALEPSTGKILAMVSSPSYDPNLLASHDPEVQAQAWQRLRDDPDDPLVNRAISETYPPGSTFKVITTAAALQSGATENEQLTAAPTIPLPNSTATLENYGGTPCGDQPTVTLSQAFAKSCNTAFVQLGIRTGAEALRSMARSFGLDSTPSVIPLQVSESTVGIIADGAALGMSSIGQKDVALTPLQNAEIAATIANNGVTMQPYLVESLKGPDLANITTTAPYQQRRAVTPQIAAKLTELMVGAEKDAQQKGAIPGVQIASKTGTAEHGTDPRNTPPHAWYIAFAPAEAPRVAVAVLVENGADRLSATGGALAAPIGRAVIQAALQGGP
>NZ_AP022568.1|WP_101528340.1|2658535_2659867_+|serine/threonine-protein-kinase
MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDSRLGRRVAVKVLKGEFSQDPEFIERFRAEARTTAMLNHPGIAAVHDYGESQMDGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQVAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDATPASDVYSLGVVGYEVVSGKRPFTGDGALTVAMKHIKEPPPPLPPELPPNVRELIEITLVKNPGMRYRSGGPFADAVAAVRAGRRPPRPSQTPPPGRASPAAIPSSPATRAAAAAGTRSAAQRRARPSSTGHRPPPARRTFSSGQRALLWAAGVLGALAIIIAVLIVINSRADTQQQPPPPPTVTDTGIPPTTAPPPSKTPTGSGPGLGLDWTRGPAVSNSGFQSRPPELSWANPLTPNLSPARYETPQ
>NZ_AP022568.1|WP_044509098.1|2659863_2661735_+|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase
MTTPQHLSDRYELGDILGFGGMSEVHLARDVRLHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHNDGPLPPRRAIEIIADACQALNFSHQNGIIHRDVKPANIMISTTNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEILTGEPPFTGDSPVSVAYQHVREDPVPPSKRHEGISADLDAVVLKALAKNPDNRYQTAAEMRADLVRVHNGEAPEAPKVLTDAERSSLLASGAHGPRTDPLPRQRLTDVDPDRMGGPVGRWVVAVAVLAVLTIVVVIAFNTFGGSTRDVQVPDVRGQVSADAVAALQNRGFKTRTLQKPDSTIPPDHVISTDPGANASVAAGDEIAINVSTGPEQREVPDVSSLSYSEAVSKLKAAGFSKFKQANSPSTPELLGKVIGTNPPANQTSAITNVVTVIVGSGPETKQVPDVAGQTVDVAQKNLTVYGFTKVTQAQVDSIRPAGEVVGTNPPKGQTVPVDSIIELQVSKGNQFTMPDLTGMFWTDAEPRLRALGWTGVLDKGPDVDAGGSQSHRVVYQNPPAGSGVNRDGIITLKFGQ
>NZ_AP022568.1|WP_044509097.1|2661712_2662408_-|aminodeoxychorismate/anthranilate-synthase-component-II
MRILVVDNYDSFVFNLVQYLGQLGVEADVWRNDDPRLAAPPDGHAAIATEFDGVLLSPGPGTPERAGASIDLVGACAASATPLLGVCLGHQAIGVAFGATVDRAPELLHGKTSSVQHSNTGVLQGLPDPFTATRYHSLTILPESLPAELQVTAQTRSGVIMAVQHTELPIHGVQFHPESILTEGGHRMLANWLSYCGWSRDDTLIRRLENEVRSAVRPYFPEPAVTDRTSA
>NZ_AP022568.1|WP_044509096.1|2662457_2663201_-|DUF881-domain-containing-protein
MRQIRRSPWSFGVPLVCLLAGLLIAATHGVAGGAEIRRSDAPRLVDLVRETQGSVDRLKAERDGLVGKIDSTHLKSPDAALAAMLRRSAELAAEADMTPVHGPGLIVTLDDAQRDANGRFPRDASPDDLVVHQQDIVAVLNALWSSGAEAIQMQDQRIIPTSVPRCVGNTLLLNGRTYSPPYTITAIGNAPAMQAALAAAPLVILYKQYVVRFGLGYHEDVKPDVQIVGHTEPARTHYAEPDAPIGY
>NZ_AP022568.1|WP_044509095.1|2663319_2663601_+|cell-division-protein-CrgA
MPKSKVRKKNDFTVSAVSRTPVKVKVGPSSVWFVALFVGLMLIGLVWLMVFQLAAVGSQAPTALHWMAQLGPWNYAIAFAFMITGLLLTMRWH
>NZ_AP022568.1|WP_044509094.1|2663756_2664191_+|PH-domain-containing-protein
MQQTSWEPHAGGIAGCGLAGVLMATISVTVVTDPPGRVLAGVAGIGLLVFAGGTWRARPKLAITPAGLTIRGWFRTQVLQQSDIKIIRITEFRRFGRKVRFLELETADGGLSLLSRWDLGTDPLDVLDALTAAGYAGRNGAEPA
>NZ_AP022568.1|WP_044512578.1|2664217_2664766_-|peptidylprolyl-isomerase
MADSGVVTNSPHQTATATLHTNRGDIKIALFGNHAPKTVANFVGLAQGTKEYSTQNASGGPSGPFYDGAVFHRVIQGFMIQGGDPTGTGRGGPGYQFADEFHPELQFDKPYLLAMANAGPGTNGSQFFITVGKTPHLNRRHTIFGEVTDPDSQQVVEAISTTPTDGNDRPTEPVVIESITIS
>NZ_AP022568.1|WP_044509093.1|2664903_2665341_+|cell-wall-synthesis-protein-CwsA
MSANAQSRLTPRQRLSRGLTYSAVGPVDVTRGLIGLGVDSAQSTASELRRRYRHGRLSREIAAAQETLAQELAAAQDVVASLPQALQSARKSRRRRGKRPLLIVGAAVVVLAGGAAAFSIVRRSVNRGTPEPSPRPPSVDVQPRP

Crispr_ID: NZ_AP022568_4

• CRISPR_ID: NZ_AP022568_4
• CRISPR_location: 2695513-2695598
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP022568_4

Consensus_repeat	Method
GCGGGCCGTCCCGGCCCGCATCGTCACCCG	CRISPRCasFinder

spacers of NZ_AP022568_4

>4.1|2695543|26|NZ_AP022568|CRISPRCasFinder
GGGGTGTTGGATGGTCGGGTTCCTGC

CRISPR arrays and Neighbor proteins around NZ_AP022568_4

CRISPR arrays

The CRISPR arrays of NZ_AP022568_4

>merge|NZ_AP022568|4|2695513-2695598|CRISPRCasFinder
GCGGGCCGTCCCGGCCCGCATCGTCACCCGGGGGTGTTGGATGGTCGGGTTCCTGCGCGGGCCGTCCCGGCCCGCATCGTCACCCG

>NZ_AP022568|4|4|2695513-2695598|CRISPRCasFinder
GCGGGCCGTCCCGGCCCGCATCGTCACCCG	GGGGTGTTGGATGGTCGGGTTCCTGC
GCGGGCCGTCCCGGCCCGCATCGTCACCCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022568.1|WP_044512572.1|2681538_2682354_+|ParA-family-protein	unknown	unknown	gnl|CDD|224113
NZ_AP022568.1|WP_044509071.1|2697743_2698067_+|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl|CDD|377587
NZ_AP022568.1|WP_081662120.1|2699460_2700366_+|MinD/ParA-family-protein	unknown	unknown	gnl|CDD|223531
NZ_AP022568.1|WP_044509079.1|2685758_2686112_-|thioredoxin	unknown	unknown	gnl|CDD|200072
NZ_AP022568.1|WP_044509080.1|2684403_2685624_-|peptidoglycan-binding-protein	unknown	unknown	gnl|CDD|223929
NZ_AP022568.1|WP_101528602.1|2701855_2703517_+|type-VII-secretion-associated-serine-protease-mycosin	unknown	unknown	gnl|CDD|274856
NZ_AP022568.1|WP_044509070.1|2698118_2698409_+|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl|CDD|227179
NZ_AP022568.1|WP_044509069.1|2698468_2699302_+|ESX-secretion-associated-protein-EspG	unknown	unknown	gnl|CDD|379414
NZ_AP022568.1|WP_101528603.1|2695614_2697069_+|CCA-tRNA-nucleotidyltransferase	unknown	unknown	gnl|CDD|131739
NZ_AP022568.1|WP_044509077.1|2687211_2687910_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022568.1|WP_044509064.1|2705060_2706902_+|type-VII-secretion-AAA-ATPase-EccA	unknown	unknown	gnl|CDD|188437
NZ_AP022568.1|WP_044509072.1|2697093_2697603_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022568.1|WP_044509073.1|2694681_2695422_-|NUDIX-hydrolase	unknown	unknown	gnl|CDD|239645
NZ_AP022568.1|WP_044509081.1|2683654_2684407_+|acetyltransferase	unknown	unknown	unknown
NZ_AP022568.1|WP_044509082.1|2682376_2683360_+|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl|CDD|275105
NZ_AP022568.1|WP_101528606.1|2700377_2701859_+|type-VII-secretion-integral-membrane-protein-EccD	unknown	unknown	gnl|CDD|274855
NZ_AP022568.1|WP_044509078.1|2686108_2687119_-|thioredoxin-disulfide-reductase	unknown	unknown	gnl|CDD|273540
NZ_AP022568.1|WP_101528601.1|2703513_2705064_+|type-VII-secretion-protein-EccE	unknown	unknown	gnl|CDD|274857
NZ_AP022568.1|WP_044509075.1|2688680_2692289_-|membrane-protein	unknown	unknown	gnl|CDD|223800
NZ_AP022568.1|WP_044509074.1|2692285_2694685_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP022568.1|WP_044512572.1|2681538_2682354_+|ParA-family-protein	gnl|CDD|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	4.90423e-86
NZ_AP022568.1|WP_044509071.1|2697743_2698067_+|WXG100-family-type-VII-secretion-target	gnl|CDD|377587	pfam06013, WXG100, Proteins of 100 residues with WXG. ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.	0.00112934
NZ_AP022568.1|WP_101528606.1|2700377_2701859_+|type-VII-secretion-integral-membrane-protein-EccD	gnl|CDD|274855	TIGR03920, T7SS_EccD, type VII secretion integral membrane protein EccD. Members of this family are EccD, a component of actinobacterial type VII secretion systems (T7SS) with ten to eleven predicted transmembrane helix regions. [Protein fate, Protein and peptide secretion and trafficking].	6.15184e-60
NZ_AP022568.1|WP_044509079.1|2685758_2686112_-|thioredoxin	gnl|CDD|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	2.10182e-50
NZ_AP022568.1|WP_044509080.1|2684403_2685624_-|peptidoglycan-binding-protein	gnl|CDD|223929	COG0860, AmiC, N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane].	4.33925e-56
NZ_AP022568.1|WP_044509070.1|2698118_2698409_+|WXG100-family-type-VII-secretion-target	gnl|CDD|227179	COG4842, COG4842, Uncharacterized protein conserved in bacteria [Function unknown].	6.98561e-05
NZ_AP022568.1|WP_101528603.1|2695614_2697069_+|CCA-tRNA-nucleotidyltransferase	gnl|CDD|131739	TIGR02692, putative_tRNA_nucleotidyltransferase, tRNA adenylyltransferase. The enzyme tRNA adenylyltransferase, also called tRNA-nucleotidyltransferase and CCA-adding enzyme, can add or repair the required CCA triplet at the 3'-end of tRNA molecules. Genes encoding tRNA include the CCA tail in some but not all bacteria, and this enzyme may be required for viability. Members of this family represent a distinct clade within the larger family pfam01743 (tRNA nucleotidyltransferase/poly(A) polymerase family protein). The example from Streptomyces coelicolor was shown to act as a CCA-adding enzyme and not as a poly(A) polymerase. [Protein synthesis, tRNA and rRNA base modification].	0
NZ_AP022568.1|WP_044509069.1|2698468_2699302_+|ESX-secretion-associated-protein-EspG	gnl|CDD|379414	pfam14011, ESX-1_EspG, EspG family. This family of proteins contains the the EspG1, EspG2 and EspG3 proteins from M. tuberculosis. These proteins are involved in the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis which is important for virulence and intercellular spread. Proteins in this family are typically between 254 and 295 amino acids in length.	1.42776e-29
NZ_AP022568.1|WP_044509064.1|2705060_2706902_+|type-VII-secretion-AAA-ATPase-EccA	gnl|CDD|188437	TIGR03922, T7SS_EccA, type VII secretion AAA-ATPase EccA. This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking].	0
NZ_AP022568.1|WP_044509073.1|2694681_2695422_-|NUDIX-hydrolase	gnl|CDD|239645	cd03673, Ap6A_hydrolase, Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most preferred substrate, hydrolyzes to produce two ATP molecules, which is a novel hydrolysis mode for Ap6A. These results indicate that Ap6A hydrolase is a diadenosine polyphosphate hydrolase. It requires the presence of a divalent cation, such as Mn2+, Mg2+, Zn2+, and Co2+, for activity. Members of the Nudix superfamily are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site.	2.05428e-46
NZ_AP022568.1|WP_101528602.1|2701855_2703517_+|type-VII-secretion-associated-serine-protease-mycosin	gnl|CDD|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	6.84553e-70
NZ_AP022568.1|WP_044509082.1|2682376_2683360_+|ParB/RepB/Spo0J-family-partition-protein	gnl|CDD|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	2.55683e-75
NZ_AP022568.1|WP_101528601.1|2703513_2705064_+|type-VII-secretion-protein-EccE	gnl|CDD|274857	TIGR03923, T7SS_EccE, type VII secretion protein EccE. This model represents the transmembrane protein EccB of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccE1, EccE2, etc. This model represents a conserved core region, and many members have 200 or more additional C-terminal residues. [Protein fate, Protein and peptide secretion and trafficking].	3.22258e-53
NZ_AP022568.1|WP_044509078.1|2686108_2687119_-|thioredoxin-disulfide-reductase	gnl|CDD|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	5.41835e-157
NZ_AP022568.1|WP_044509075.1|2688680_2692289_-|membrane-protein	gnl|CDD|223800	COG0728, MviN, Uncharacterized membrane protein, putative virulence factor [General function prediction only].	3.49503e-128
NZ_AP022568.1|WP_081662120.1|2699460_2700366_+|MinD/ParA-family-protein	gnl|CDD|223531	COG0455, flhG, Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility].	1.11208e-50

Protein sequences

>NZ_AP022568.1|WP_044509073.1|2694681_2695422_-|NUDIX-hydrolase
MSDGEQAKPRRRRGRRRRRGVAKASDNDSEAKVTASPPASKTSNRRRSRTQRGVPERLRTVHETSAGGLVIDGIDGPRDSQMAALIGRIDRRGRMLWSLPKGHIELGETAEQTAIREVAEETGIQGSVLAALGRIDYWFVTEGRRVHKTVHHYLMRFSGGELSDEDLEVAEVAWVPMRELPSRLAYADERRLAQVADELIGKLQSDGPAALPPLPPSAPRRNPQTHSRTRHSDKPPGRHNGHGPGS
>NZ_AP022568.1|WP_044509074.1|2692285_2694685_-|hypothetical-protein
MTAPRIRWAGLLRLAAVVALVAGCTVLLTGPVGVPRAGADEPASTPFIRVRIDQVTPDVVTTTSPPVVTVSGMVANIGDRPVRDVMVRLEHAAAVDTSAGLRTSLDGATDQYQPAADFLTIAPELQRGQEAGFTLSAPLRSLSKPSLGINQPGIYPLLVNVNGTPDYGAPARLDNARFLLPVIGVPPDRADSLESAVAPDTSKPVWVTMLWPLADRPRLAPGQPGGTVPVRLIDDDLASSLAAGGRLDILLSAAEVATSHDVDPDGAVGRALCLAVDPDLLVTVNAMTAGYVVSSSPDGPAQQPGTPTHPGAGQGAATAWMNRLRALAHRVCVTPLPYAQADLDAVQRVNDPRLSTIATTSVGDIVDQLLDIASTRGATLLPDGPLTAGAIELLNANNSTVAVAAADLVAEDSQSSVDGPRSVDTTPRRLSPQVVMAPFDPAVGAALAGAGNNPTVPTYLDPSLTVRLTHDSNTARRQDALGSMFWHALDHDAPPRTQLLVPPATWNLQADDAQVILTALATTIRSGLGVPRPLGAVIAEAAARTEPGAPPTVPAPGRGRFSETVTTDINGQTGRLSRLTSALTTDERTGLTGVQYTAPLREDMLRALSQSEPPDGRNELAKQRLQVVGNTINDLFGAVTIVNPGGSYTLATEHSPLPLALHNGLAVPIKVRLQVDAPPGMTVTDVGQIELPPGYLPLRVPIEVNFTQRVAIDVTLRTPDGTRLGEPVRLSVHSNAYGKVLFAITLTAAAVLFVLAGRRLWHRFRGQPDRADLDRPDPPHHQAADPHGVAIRVDEEHRV
>NZ_AP022568.1|WP_044509075.1|2688680_2692289_-|membrane-protein
MNPAYRRPHAHQPPRRHQPPPTGPLPPVTELPTRRVELSDSALVSRSWAMAFATLISRITGFGRIVVLAAILGAALSSAFSVANQLPNLVAALVLEATFTAIFVPVLARAEQSDPDGGAAFVRRLVTVTTTLLLFATAVSVVAAPLLVRLMLGHNPQVNEPLTTAFAYLLLPQVLAYGLTSVFMAILNTRNVFGPTAWAPVVNNVVALLTLAVYLLVPGELSVDPVRMGNAKLLVLGIGTTLGVFAQTAVLLVALRRERVSLRPLWGIDERLKRFGTMAAAMVLYVLISQLGLVVGNQIASTAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNAAANDTDAVLADLSLATRLTLITLIPIVAIMTVAGPAIGSALFAYGHFGGTDAGYLGAAIALSAFTLIPYGLVLLQLRVFYAREQPWTPIVIILVITAVKIAGSVLAPHATDDPQLVAGFLGLANGIGFLAGAIVGYVLLRHALLPAGGHLIGRAEVRTILVTIVASMLGGLIAHVVDRLLGLADLTARGGAAGSLLRLLILGCLMLPIMATVMVRAQVPEALAALAAVRRRVGGRSRMALQSGPPATPRGSSHRGPVTYPEQRNSSPPGVDAVQEPIRRRPPERAGNARLMKGPEVTDRPVESAAPGPGGDRPRATADDFQPDMPTAREASPSVPRPPEQRNGGAPGESTRGAIPVDASRDRGADSRGDDPHLVPGARIAGGRYRLLVFHGGAPPLQFWQALDTALDRQVALTFVDPDGSLPADVLQEILSRTLRLSRIDKPGIARVLDVVHSQQGGLVVAEWIRGGSLQEVADTAPSPLGAVRAMQSLAAAADAAHRAGVALSIDHPSRIRVSIDGDVVLAYPATMPDANPEDDIRGIGAALYALLVNRWPLPESGVRSGLAPAERDASGLPVEPSTIDRDIPFQVSAVAVRAAQEDGGIRSASTLLNLLQQATAVADRTEVLGPIDDSPPPPAAAPVERDNYATLARRRRNLLIGGAAAIAVIVVALLVLASIVSKIFGNVGGGLNKDELGLNGPSSSSASSSASAAPSGSVIKPTRATVYSPDGEADNPGQAAMAIDGNSTTGWQTDIYTDAVPFPSFKNGVGLMLQLPSPTVVGAVSIDTPSTGTKVEIRSSSSASPARLEDTSLLVSATPLKPGHNTIPVRSGAQTSNVLVWITTLGNTDGKNRSELSNITIQAAS
>NZ_AP022568.1|WP_044509077.1|2687211_2687910_-|hypothetical-protein
MPGVELLADLQAGLLDDESAARVRRQVRDDPDAHRVLQALHQVRRDVAAVGADPESAPEPPATTTARIADALRAERTGTATHSARPGVRPGKILAGAAGIGAVLAAAGFGTAALLHEPPSAPSTPTTIEHITVSTPPMAIPLSAAEISGLLGRVPDYGPLADASRRASCLAGLGYPAATQVLGARAIEINARPGVLLVLPADTPTDLVVFAVALNCSAADTGLLASTQIPRP
>NZ_AP022568.1|WP_044509078.1|2686108_2687119_-|thioredoxin-disulfide-reductase
MSETAHDTVHDVIIIGSGPAGYTAALYTARAQLAPLVFEGTSFGGALMTTTEVENYPGFRDGITGPELMDQMREQALRFGADLRMEDVESVSLQGPVKSVTTAEGETFKARAVILAMGAAARYLQVPGEQELLGRGVSACATCDGFFFRDQDIAVIGGGDSAMEEATFLTRFARSVTLVHRRDEFRASKIMLDRALSNDKITFMTNQSVVAVEGEATVTGLRLRDNLTGAETVLPVTGVFVAIGHDPRSALVRDVIDVDADGYVQVKGHTTHTTIEGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHDEAEAGQPEAGNADSTDLIGAPR
>NZ_AP022568.1|WP_044509079.1|2685758_2686112_-|thioredoxin
MTDAEKAGATKEVSDASFSTEVLSSEKPVLVDFWATWCGPCKMVAPVLEEIAAERSDQLTVAKLDVDANPETARDFQVVSIPTMILFKDGQPVKRIVGAKGKAALLRELSDAVPNLT
>NZ_AP022568.1|WP_044509080.1|2684403_2685624_-|peptidoglycan-binding-protein
MSSPRRENGDALRCGDRSAAVTEIRASLAALGLLDNSEDDLRTGRQVASDVFDSQLDQAVRAFQQHRGLLVDGVVGEATYRALKEASYRLGARTLYHQFGAPLYGDDVATLQARLQDLGFYTGLVDGHFGLQTHNALMSYQREYGLSADGICGPETLRSLYFLSSRVSGGSPHAIREEELVRRSGPRLSGKRIIIDPGRGGDDHGLIAQGPAGPISEADILWDLASRLEGRMTAIGMETFLSRPTNRSPSDAERAATANNVGADLMISLRCEAQVSPSANGVASFHFGNSHGSVSTIGRNLADFIQREVVARTGLRDCRTHGRTWDLLRLTRMPTVQVDVGYITNPGDRERLISTHTRDAIAEGILAAVKRLYLLGKNDRPTGTFTFAELLAHELSVERTTRLGGS
>NZ_AP022568.1|WP_044509081.1|2683654_2684407_+|acetyltransferase
MSARITPLRLEAFEQLPKHARRCVYWEVDPATLGDQDHLADPEFEKEAWLSMVMLEWGSCGQVATAIPDERSQAEPPCLGYVLYAPPGAVPRARRFPTAPVSADAVLLTSMGIEPGNAADDLAHSLLVQVIDELMRRGVRALEAFGRTPAVSELSDPRLADTATRPVLESICDCSVERCIIDAEFLQDVGFVVVAPHSYFPRLRLELDKGLGWKAEVEAALERLLANAQLQQPVGAGSAAGNTLQNKKNG
>NZ_AP022568.1|WP_044509082.1|2682376_2683360_+|ParB/RepB/Spo0J-family-partition-protein
MTHPSRRKGGLGRGLASLIPTGPAEGDSGPATLGPRMGDAAADVLIGGPAPSVNEMGAVYREIAPSDIEPNPRQPRQVFDDEALAELVHSIREFGLLQPIVVRAVSGSPGGARYQLVMGERRWRAAQAAGLATLPAIVRETTDDNLLRDALLENIHRAQLNPLEEAAAYQQLLDEFGVTHDELAARIGRSRPLITNMIRLLKLPIPVQRRVAAGVLSAGHARALLSLEAGPEAQEELASRIVAEGLSVRATEEAVTLANRGDTATPPAPRRKPIQMPGLQDVADRLSNAFDTRVTVSLGKRKGKIVVEFASVEDLQRIVDAIDPPKA
>NZ_AP022568.1|WP_044512572.1|2681538_2682354_+|ParA-family-protein
MRVLHTTYPPLPKPSHRRVFTVANQKGGVGKTTTAVNLAAALALQGLKTLVIDLDPQGNASTALGITERQSGTPSSYEVLLGEETLESALRRSPHSDRLYCVPATIDLAGAEIELVSMVARENRLRTALAQLEGFDFDYVFVDCPPSLGLLTINALVAAPEVMIPIQCEYYALEGVSQLMRNIEMVKAHLNPQLDVTTVVLTMYDGRTKLADQVAEEVRRYFGSKVLRTVIPRSVKVSEAPGYSMTIIDYDPGSRGAMSYLDASRELAQRD
>NZ_AP022568.1|WP_101528603.1|2695614_2697069_+|CCA-tRNA-nucleotidyltransferase
MSDAAQDVELLASAAVTLNRHAEVLRELGALFEAAGHELYLVGGSVRDALLRRLSPDLDFTTGARPEQVQHIVRGWADAVWDTGIAFGTVGVGKGDLRLEITTFRADSYDQVSRNPEVRFGDRLEDDLVRRDFTANAMAVRITAAGPGDFVDPLGGLAALRARVLDTPAAPEVSFGDDPLRMLRAARFVAQLGFTVAPRVRTAIEEMAPQLARISAERVAVELDKLLLGTDPVAGIDLVVQTGMGDVVLPEVGGMQMAIDEHHQHKDVYQHSLTVLRQAIALEDPPPEGGPDLVLRWAALLHDIGKPATRRHEPDGGVSFHHHEVVGAKMVRKRLRALKYSKQMVDDVSQLVYLHLRFHGYGDGKWTDSAVRRYVTDAGPLLPRLHKLVRADCTTRNKRRAARLQANYDRLEARIAELAAQEDLARVRPDLDGNRIMELLNIPAGPQVGEAWRFLKELRLDRGPLTEEEATAQLLAWWKARGNG
>NZ_AP022568.1|WP_044509072.1|2697093_2697603_+|hypothetical-protein
MDYCLSSGDGSAAIWHGQPDLDLDHDGRPESIGLDIDQDGLRDDALSDFDSDGVVDHAVLDLDNDGTPEAYFTDDGTGTWAVTVDRGGSLRWYGLDGSEHTGGPLVDFDGRGHPDDWLVDIDGNGVADRALCTDETGVTGYVDTDGDGRWDVRLTDTDGDGAADGASTV
>NZ_AP022568.1|WP_044509071.1|2697743_2698067_+|WXG100-family-type-VII-secretion-target
MAGSTVVTPELLRSSKQRIEARLEEAAAIANQYLSGHENIVSAAGWSGQAGSTSLNTAGQIAHDLQQIMTGGNRLAHGLAQTATLMEHHEADSAHSLNGVFGGVQST
>NZ_AP022568.1|WP_044509070.1|2698118_2698409_+|WXG100-family-type-VII-secretion-target
MADHIVYNHAAVSGLSGDIAAQASQLMEIHDDVLHITQQLAEFFQGHGATTFFDAQQQMLHGLQDMIQTVSLHGHTVNSVHENAIITDHNTSLFFA
>NZ_AP022568.1|WP_044509069.1|2698468_2699302_+|ESX-secretion-associated-protein-EspG
MLTTSLEGLWVLQVLTGIEVVAPEMGLRPHLPSVEPKQKALQHPVTPELRAAGVIDETDSVDGTIVEWLTVLSRRDIGLMIHFRLPGDGEPTRALLARFAHWWVSIERSGDLVRISGAGIASNESAAGEALSAQIERLCGASDPAPLRPVTLDVDAMRATATDQHRLHEFLASQGLEPDQLHLLKLATDTDRSAQASIVAIQSGVDSGRPTRTHIDQGAVTIIDTPEGRLVAEHVPSAGKQWMIIAPGTKNNIGSAISHMMRRLPADQEWYSYRKVV
>NZ_AP022568.1|WP_081662120.1|2699460_2700366_+|MinD/ParA-family-protein
MVAPRKIPPGGGWRKFIYQATFHAVNFGESPAERHYRELQERIRRHIRKQYVIGVVSGKGGVGKTTLTACIGAVFRECRPENVVAIDAAPGFGTLAGRIDESPPGDYAAVLNDTDVQGYADIREHLGQNSLGLDVLAGNRASDQPRPLVASMFAGVLSRLRRTHTVIVVDTSDDLEHPVMKAVLDACDTLVFVSGLTADTSLPVTRSIDLLRSMGYHELVSRSMVILNDSRNKYDGEARTYLTERFAQSGATVEFMPYDPFLAKGGIIDTQHELKKKTRLRLFEITAALADKYIPDADRPR
>NZ_AP022568.1|WP_101528606.1|2700377_2701859_+|type-VII-secretion-integral-membrane-protein-EccD
MGKVSFPARCAVAVVCGEHLVSQVYPASVPIEVFLDNVVELLNEELKRRGFAGLESGIGYELHKANGVRLDVTKTLDELGVEDGATLTLVPAVAGESFEPQYESLSTGLARVGKALFEPVTLQTAARTALVILAMATLTVLGLVVRQRVSTDALMPTIVSGAAGLLIAGGAATVWRWWPGRLDMIDGLGWIAVPLLTVSLASGAPGRLGAAHAFIAALAGAVLTCGMASATRRHANVAATMVTVLALGGLVAAARMWWPVPAQWLGMCTLVALLLLLTMAPTIALWVARIRPPYFGSITGRDLFRRSAGLPADAVAPVDEGSDEEANSDTTPRGAQIAASAIRANNVLTGICAGAGLALPIAVWATLMPGRDRSTPAAVLAALFVVIFISRGRAFADKRQAVALVCGAAAAVCVGVIKYVVHEPASSGSGLLWGALVLAAFGGAGLLSALLVPITRFTPLVRMTAEWVEIVAIIAALPLAAWIGGLFTWVRMR
>NZ_AP022568.1|WP_101528602.1|2701855_2703517_+|type-VII-secretion-associated-serine-protease-mycosin
MTRLPRAAALAQRVGAAALTTVIVTLIAGLPAAQAIPPPVVDPGRVPADGKPAAEQPMRQSFACARTITVADPNVALPAPGFTMLNVSKAWQYSTGNGVAVAVIDTGVNPSHRLPVVAGGDYIMGGDGLSDCDAHGTVVASVIGAAPQGTPMPAPMPSAPAFPPPAGPPPTDAGAPPPGGPPPPPAPPPPPSPVTITQTVPAAPPPPPPPPDAPSNGPGDPAPGQPDDPEVPPPPPGAPDGVVGVAPHATIISIRQSSRAFEPVNPGPGDSEGRKKAGTIATLASAIVHAANMGAKVINISVTACVSAADPLDQGAIGAAVWYAATVKDAVLVAAAGNDSEDGCAQNPTFDPLNAADPRDWHQVKTVSSPSWFSDYVLSVGAVDNTGAPINKSLAGPWVAAAAPGVGIIGLSPETGGPANAYPPIRPGEKNMPFWGTSFSAAYVSGVAALVRAKYPALSAHQIINRILQTAHNPPRGVDNQVGYGVVDPVAALTFDVPAGDRLPPGAASRVVHPLPPPPPPDHRARNVALVFAGVVVAAIAVVSLLVRARRER
>NZ_AP022568.1|WP_101528601.1|2703513_2705064_+|type-VII-secretion-protein-EccE
MRAGTRLTIIVAIFIAAVAGWAAGGYPGATVGLVIGIAVGVIRWRGQPVWSWMILWRRRRRPIWWTEPLTVANDRAGGGIRYQDGVAAAAVQLLGKAHAPTLFTGSTATLTDNAFDITDLAPLLHQSLGLTVGSLSVISAGARRRSTGDYPRVYDTLIGTPPYAGQRETWLIVRISALDNVEALRGRTSVGTATLAAAQRISAAMRQQGIRAKVATATDIVEMERRLGRSALDVSNRRWRSVRSDSGWLTTYWYPPGDVTTDTLAQAWSARVDGIVQNVTLFGAEAGPVTVTATVTVRTAQPPTAPLSMRLRTLRGEQAQAVAANLCGPLPALRGIRRGALRSPLVIPIGPSGVLLGKVVGGNRMLLPFDDAGEFSRVHIAAEDALVKRFIIRLAGAGERITVHTRNLRRWASVRMPDIAVTDQPKPASGTTVSVVDGSMSPAPRPNTLISVGSPGEAYRGTANVLITQTGPATVDVTAAGQVHSVEVELFRAENRYVSSEPMALRTPELEAIDTP
>NZ_AP022568.1|WP_044509064.1|2705060_2706902_+|type-VII-secretion-AAA-ATPase-EccA
MTSPVTARKYFDQAMALLDTDVAGAAARFREATEVDPSMADAWLGRIAAGDEALSTIEQLYTCGSRLHRETNRIGARLSAPIKAGPYLSISVTEASHAGLALASALIDDRQYEKAEALLADSTLLDTWENHQWKQYIEAYLMFATQRWPDVVSVAAAILPPQAIIMSAVTAAICTLAAHAAAHLGQARVALEWTDRVELRTGYGGPTEARRQHLETAVTAIDPNDFPLIAADLAYVRGMAHRQLGEEPKAQIWLSKATINGALLEPAKQALADPALQLVVTDEQSIRSRTNKWDVTTERSAQQREEEEHQERRSELLQEGRALLDNQVGLADVKRAVAELEDQIEVRALRLAAGLPVANQTNHMLLVGPPGTGKTTTAEALGKIYAGLGIVRHPEIIEVKRADFCGEHIGASGPKTNELINRSLGRILFMDEFYSLVERHQDGRPDMIGMEAVNQLLVALEVHRFDFCFIGAGYEKEVDEFLTVNPGLAGRFNRKLRFESYTPDELVEIAVRYGKPRATLLDPATADALRAACATLRDYRAPNGEHGIDVMHNGRFARNVVERAERLRDSRVAAQHRVDKGSVTVEDLQTLRTQDIVAAVKDACAEKHVPLVL

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP022568_1	1.1|306753|29|NZ_AP022568|CRISPRCasFinder	306753-306781	29	NZ_CP021355	Rhodococcus sp. S2-17 plasmid pRB98, complete sequence	510613-510641	3	0.897
NZ_AP022568_1	1.1|306753|29|NZ_AP022568|CRISPRCasFinder	306753-306781	29	NZ_CP050953	Rhodococcus sp. DMU1 plasmid unnamed	7263-7291	3	0.897
NZ_AP022568_1	1.1|306753|29|NZ_AP022568|CRISPRCasFinder	306753-306781	29	NZ_CP021355	Rhodococcus sp. S2-17 plasmid pRB98, complete sequence	461279-461307	4	0.862
NZ_AP022568_1	1.1|306753|29|NZ_AP022568|CRISPRCasFinder	306753-306781	29	NZ_CP032676	Rhodococcus rhodochrous strain ATCC BAA870 plasmid pNit, complete sequence	353739-353767	4	0.862
NZ_AP022568_1	1.1|306753|29|NZ_AP022568|CRISPRCasFinder	306753-306781	29	NZ_CP024891	Rhodococcus ruber strain YYL plasmid pYYL1.2, complete sequence	56064-56092	5	0.828
NZ_AP022568_1	1.1|306753|29|NZ_AP022568|CRISPRCasFinder	306753-306781	29	NZ_CP024892	Rhodococcus ruber strain YYL plasmid pYYL1.1, complete sequence	103917-103945	5	0.828
NZ_AP022568_1	1.1|306753|29|NZ_AP022568|CRISPRCasFinder	306753-306781	29	NC_005073	Rhodococcus erythropolis linear plasmid pBD2, complete sequence	179987-180015	5	0.828
NZ_AP022568_3	3.1|2654089|29|NZ_AP022568|CRISPRCasFinder	2654089-2654117	29	MN602278	Escherichia coli plasmid pUZ8002, complete sequence	42400-42428	5	0.828
NZ_AP022568_3	3.1|2654089|29|NZ_AP022568|CRISPRCasFinder	2654089-2654117	29	JX469830	Uncultured bacterium plasmid pG527, complete sequence	5943-5971	5	0.828
NZ_AP022568_3	3.1|2654089|29|NZ_AP022568|CRISPRCasFinder	2654089-2654117	29	JX469833	Uncultured bacterium plasmid pWEC911, complete sequence	5946-5974	5	0.828
NZ_AP022568_3	3.1|2654089|29|NZ_AP022568|CRISPRCasFinder	2654089-2654117	29	NC_008357	Pseudomonas aeruginosa plasmid pBS228, complete sequence	30266-30294	5	0.828
NZ_AP022568_3	3.1|2654089|29|NZ_AP022568|CRISPRCasFinder	2654089-2654117	29	CP002151	Uncultured bacterium plasmid PB5, complete sequence	5943-5971	5	0.828
NZ_AP022568_3	3.1|2654089|29|NZ_AP022568|CRISPRCasFinder	2654089-2654117	29	CP002152	Uncultured bacterium plasmid PB11, complete sequence	5940-5968	5	0.828
NZ_AP022568_3	3.1|2654089|29|NZ_AP022568|CRISPRCasFinder	2654089-2654117	29	CP002153	Uncultured bacterium plasmid PSP21, complete sequence	5943-5971	5	0.828
NZ_AP022568_3	3.1|2654089|29|NZ_AP022568|CRISPRCasFinder	2654089-2654117	29	MT708550	Achromobacter phage Mano, complete genome	35610-35638	5	0.828
NZ_AP022568_3	3.1|2654089|29|NZ_AP022568|CRISPRCasFinder	2654089-2654117	29	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	3313176-3313204	6	0.793
NZ_AP022568_3	3.1|2654089|29|NZ_AP022568|CRISPRCasFinder	2654089-2654117	29	NZ_CP013855	Pseudonocardia sp. HH130630-07 plasmid pLS2-1, complete sequence	285083-285111	6	0.793
NZ_AP022568_3	3.1|2654089|29|NZ_AP022568|CRISPRCasFinder	2654089-2654117	29	NZ_CP032326	Azospirillum brasilense strain MTCC4035 plasmid p5, complete sequence	57067-57095	6	0.793
NZ_AP022568_3	3.1|2654089|29|NZ_AP022568|CRISPRCasFinder	2654089-2654117	29	NZ_CP043441	Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence	737725-737753	6	0.793
NZ_AP022568_3	3.1|2654089|29|NZ_AP022568|CRISPRCasFinder	2654089-2654117	29	KR053199	Gordonia phage GMA4, complete genome	7654-7682	7	0.759
NZ_AP022568_3	3.1|2654089|29|NZ_AP022568|CRISPRCasFinder	2654089-2654117	29	NZ_CP016082	Streptomyces sp. SAT1 plasmid unnamed2, complete sequence	88997-89025	7	0.759
NZ_AP022568_3	3.1|2654089|29|NZ_AP022568|CRISPRCasFinder	2654089-2654117	29	CP054922	Streptomyces sp. NA03103 plasmid unnamed2, complete sequence	30306-30334	8	0.724
NZ_AP022568_3	3.1|2654089|29|NZ_AP022568|CRISPRCasFinder	2654089-2654117	29	CP054921	Streptomyces sp. NA03103 plasmid unnamed1, complete sequence	81081-81109	8	0.724

1. spacer 1.1|306753|29|NZ_AP022568|CRISPRCasFinder matches to NZ_CP021355 (Rhodococcus sp. S2-17 plasmid pRB98, complete sequence) position: , mismatch: 3, identity: 0.897

ctctcccccgcaagcgggaggtaccccca	CRISPR spacer
tcgtcccccgcaagcgggaggtaccccca	Protospacer
.. **************************

2. spacer 1.1|306753|29|NZ_AP022568|CRISPRCasFinder matches to NZ_CP050953 (Rhodococcus sp. DMU1 plasmid unnamed) position: , mismatch: 3, identity: 0.897

ctctcccccgcaagcgggaggtaccccca	CRISPR spacer
ccctcccccgcacgcgggcggtaccccca	Protospacer
*.********** ***** **********

3. spacer 1.1|306753|29|NZ_AP022568|CRISPRCasFinder matches to NZ_CP021355 (Rhodococcus sp. S2-17 plasmid pRB98, complete sequence) position: , mismatch: 4, identity: 0.862

ctctcccccgcaagcgggaggtaccccca	CRISPR spacer
tacgcccccgcaagcgggagggaccccca	Protospacer
. * ***************** *******

4. spacer 1.1|306753|29|NZ_AP022568|CRISPRCasFinder matches to NZ_CP032676 (Rhodococcus rhodochrous strain ATCC BAA870 plasmid pNit, complete sequence) position: , mismatch: 4, identity: 0.862

ctctcccccgcaagcgggaggtaccccca	CRISPR spacer
tcctcccccgcaagcgggtggtgccccca	Protospacer
..**************** ***.******

5. spacer 1.1|306753|29|NZ_AP022568|CRISPRCasFinder matches to NZ_CP024891 (Rhodococcus ruber strain YYL plasmid pYYL1.2, complete sequence) position: , mismatch: 5, identity: 0.828

ctctcccccgcaagcgggaggtaccccca	CRISPR spacer
tggtcccccgcgagcgggaggtgccccca	Protospacer
.  ********.**********.******

6. spacer 1.1|306753|29|NZ_AP022568|CRISPRCasFinder matches to NZ_CP024892 (Rhodococcus ruber strain YYL plasmid pYYL1.1, complete sequence) position: , mismatch: 5, identity: 0.828

ctctcccccgcaagcgggaggtaccccca	CRISPR spacer
tggtcccccgcgagcgggaggtgccccca	Protospacer
.  ********.**********.******

7. spacer 1.1|306753|29|NZ_AP022568|CRISPRCasFinder matches to NC_005073 (Rhodococcus erythropolis linear plasmid pBD2, complete sequence) position: , mismatch: 5, identity: 0.828

ctctcccccgcaagcgggaggtaccccca	CRISPR spacer
tgttcccccgcacgcgggaggtgccccca	Protospacer
. .********* *********.******

8. spacer 3.1|2654089|29|NZ_AP022568|CRISPRCasFinder matches to MN602278 (Escherichia coli plasmid pUZ8002, complete sequence) position: , mismatch: 5, identity: 0.828

gcgcac-acgacgaagaggccggcttggcg	CRISPR spacer
-tgctcgacgccgaagaggacggcttggcg	Protospacer
 .** * *** ******** **********

9. spacer 3.1|2654089|29|NZ_AP022568|CRISPRCasFinder matches to JX469830 (Uncultured bacterium plasmid pG527, complete sequence) position: , mismatch: 5, identity: 0.828

gcgcac-acgacgaagaggccggcttggcg	CRISPR spacer
-tgctcgacgccgaagaggacggcttggcg	Protospacer
 .** * *** ******** **********

10. spacer 3.1|2654089|29|NZ_AP022568|CRISPRCasFinder matches to JX469833 (Uncultured bacterium plasmid pWEC911, complete sequence) position: , mismatch: 5, identity: 0.828

gcgcac-acgacgaagaggccggcttggcg	CRISPR spacer
-tgctcgacgccgaagaggacggcttggcg	Protospacer
 .** * *** ******** **********

11. spacer 3.1|2654089|29|NZ_AP022568|CRISPRCasFinder matches to NC_008357 (Pseudomonas aeruginosa plasmid pBS228, complete sequence) position: , mismatch: 5, identity: 0.828

gcgcac-acgacgaagaggccggcttggcg	CRISPR spacer
-tgctcgacgccgaagaggacggcttggcg	Protospacer
 .** * *** ******** **********

12. spacer 3.1|2654089|29|NZ_AP022568|CRISPRCasFinder matches to CP002151 (Uncultured bacterium plasmid PB5, complete sequence) position: , mismatch: 5, identity: 0.828

gcgcac-acgacgaagaggccggcttggcg	CRISPR spacer
-tgctcgacgccgaagaggacggcttggcg	Protospacer
 .** * *** ******** **********

13. spacer 3.1|2654089|29|NZ_AP022568|CRISPRCasFinder matches to CP002152 (Uncultured bacterium plasmid PB11, complete sequence) position: , mismatch: 5, identity: 0.828

gcgcac-acgacgaagaggccggcttggcg	CRISPR spacer
-tgctcgacgccgaagaggacggcttggcg	Protospacer
 .** * *** ******** **********

14. spacer 3.1|2654089|29|NZ_AP022568|CRISPRCasFinder matches to CP002153 (Uncultured bacterium plasmid PSP21, complete sequence) position: , mismatch: 5, identity: 0.828

gcgcac-acgacgaagaggccggcttggcg	CRISPR spacer
-tgctcgacgccgaagaggacggcttggcg	Protospacer
 .** * *** ******** **********

15. spacer 3.1|2654089|29|NZ_AP022568|CRISPRCasFinder matches to MT708550 (Achromobacter phage Mano, complete genome) position: , mismatch: 5, identity: 0.828

gcgcacacgacgaagaggccggc-ttggcg	CRISPR spacer
gcgcacacgatgaagacgccggcaccggc-	Protospacer
**********.***** ****** ..*** 

16. spacer 3.1|2654089|29|NZ_AP022568|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 6, identity: 0.793

gcgcacacgacgaagaggccggcttggcg	CRISPR spacer
ccgcacacgacgaagaggcccgccggtgg	Protospacer
 ******************* **. *  *

17. spacer 3.1|2654089|29|NZ_AP022568|CRISPRCasFinder matches to NZ_CP013855 (Pseudonocardia sp. HH130630-07 plasmid pLS2-1, complete sequence) position: , mismatch: 6, identity: 0.793

gcgcacacgacgaagaggccggcttggcg	CRISPR spacer
tcgacgacgacgagcaggccggcttggcg	Protospacer
 **   *******. **************

18. spacer 3.1|2654089|29|NZ_AP022568|CRISPRCasFinder matches to NZ_CP032326 (Azospirillum brasilense strain MTCC4035 plasmid p5, complete sequence) position: , mismatch: 6, identity: 0.793

gcgcacacgacgaagaggccggcttggcg	CRISPR spacer
ccgaccacgccgaggaggccggcttggcc	Protospacer
 **  **** ***.************** 

19. spacer 3.1|2654089|29|NZ_AP022568|CRISPRCasFinder matches to NZ_CP043441 (Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.793

gcgcacacgacgaagaggccggcttggcg	CRISPR spacer
gggtctacgacgaagcggccggcttgccg	Protospacer
* *. .********* ********** **

20. spacer 3.1|2654089|29|NZ_AP022568|CRISPRCasFinder matches to KR053199 (Gordonia phage GMA4, complete genome) position: , mismatch: 7, identity: 0.759

gcgcacacgacgaagaggccggcttggcg	CRISPR spacer
cggtcgacgacgacgaggccggcgtggcg	Protospacer
  *.  ******* ********* *****

21. spacer 3.1|2654089|29|NZ_AP022568|CRISPRCasFinder matches to NZ_CP016082 (Streptomyces sp. SAT1 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.759

gcgcacacgacgaagaggccggcttggcg	CRISPR spacer
gcgcacacgacgaggaggccgcgacgggc	Protospacer
*************.*******   .**  

22. spacer 3.1|2654089|29|NZ_AP022568|CRISPRCasFinder matches to CP054922 (Streptomyces sp. NA03103 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.724

gcgcacacgacgaagaggccggcttggcg	CRISPR spacer
gcgcacacgacggagaagccggcgaacaa	Protospacer
************.***.******  .  .

23. spacer 3.1|2654089|29|NZ_AP022568|CRISPRCasFinder matches to CP054921 (Streptomyces sp. NA03103 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.724

gcgcacacgacgaagaggccggcttggcg	CRISPR spacer
gcgcacacgacggagaagccggcgaacaa	Protospacer
************.***.******  .  .

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	223131 : 230360	6	Brazilian_cedratvirus(33.33%)	NA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NZ_AP022568|223131:230360|DBSCAN-SWA
GTTAGGACTTGCGCCACAGCACGCCCGTGCCGTCGATCTCTACGATCTCGGCGGTGATCCCGTGCTTCTCTCGGTAGTCGGCGACCGCCTGCTCGCACGGTTTCAGCGCGTGGTAGTCGTCGATGATGCAGAAGCCGCCGGAGGACAACCGCGGATACAACGCATCCAAGGCCTGAATCGTCGACTCATACAGGTCACCATCGAGGCGCAACACCGAGATCTGCTCGATCGGCGCATTGGCCAACGTGTCCTTGAACCACCCCGGCACAAAACGAACCTGATCGTCCAAGAGCCCATAACGCTCGAAGTTCGCCCGGACCACTGACTCGGGGATTCCCAGCACATTGGCGTGCCGATCCAACCGAATCCCTTTATCAGCCTTGTAATTCACCGTATCGGGCGGCGGCACCCCCTCGAAGGAATCACACAGCCACACCCGCCGCGTCTGATCCCCGTAGGCCGCCAGCACCGCGCGCATCAAGATGGACGCCCCGCCACGCCACACCCCGCACTCCACCAGATCACCGGGCACGTTGTCGGCCAGCACCGTCTCCACACAATGCTGCAAACTGGTCAGCCGCTGCATCCCGATCATCGTCAACGCATCGGCCGGCCAATCCAGACCCCGATCCCGCGCATGCGCATTGAACGGGCGCTTGCGCACCAACATGAAATTGCGCGTATTGAAAATGGGCCGTCCCAGCCGGTACCAGCCGACCGGCACCAGCTCATCCTGACCGTAGCGGGTCAGGTCACGACGGAGCAGATCAAGATAGGCAGACCGCGCGTCGGTTTCCGTCACGGTCAAAACTGTCCCTTTCCTCGCATACCACTACTCCCAGTCATGGCGCCTAGACGCCCAGCCACGCCACCAATGCGGTTCACGATCTTCCGTCAACCCCCAACGGCGGTTCGAGACATCGTCTGAACGAACCCACAGCATGGTAGCTGAGTACCCGGCGGACGTTCGGCGAATCGAGGTCTGAAGTGCGATTCGACGCCGGGATCGGCCCGACTGGCAAACGTCCGACGTGGCCGACTCCGGCCTTTGTCCTACGCGTGCCGGCGTCGAACAGGAAAACGCCCCGCTTGACCAAAACGCTCGAGGAGGTCGGCGGCGCGGGTCACACTCTGCTGCGCCGTGGTCATCCGGGTGGCGAGTTCGCGGGCACGAAGGGCGTACTCGGGGGCGAGGATTTGGCGCAAATCCTCGACCAACGTCTCCTTGGTCGTCGCGGAAAAACGGCGGCCCGCGCCCACTTTCAGCTTTTTCAGGTGGCCGCCCCAGAAAGGCTGATCGCCAGCGGTCCACAGGATCAGCGCGGGGATTCCGGCGCGCAGTCCGGCGGCCGTCGTGCCGGAGCCGCCGTGATGAACCACCGCGCGGCAGGCCGGGAAGGTCGTAGCGTAGTTCACCGCGCCCACCACCTTGACGTGGTCGAAGTGTGGCACATCGCTGAAGTCGCTCCAGCCGGCACAGATCAACGCCCGCTCGCCCAGCTCTTCGCAGGCCCCGCTGATCATCTCGATGGTGTCGGCCGGCGACTCGGTGACCGGCATGCTGCCGAACCCGAAGCAGATCGGCGGTGTGCCCGCGGCGATCCAAGACAGGACATCGTCGTCCGAGTCCGTCGTCAGGCCCATGGTCAGGGTGCCGACGAAGGGGCGCCGATCCCCCCACTTCGACCATTCGGCGGCCAAGCCTGGGAAGCACACCTCGTCGTACGCCTGAAGTTCCAGCGACCCAAGATTGGCAATCCGGCGAGGTGAGGACGACGTCGTCTTCGGTAGCCCCAGCTTGCGGCGCTGTTCGTCCTCGGCCTTTTTGTTCATCCGCCAAACAAGCCAGTCGTATGCCGTCATGCCGGCGCGGACCAGCGGCGACGGCAGATTCGGAATGAGTTGACCGTTAGGCCGCATCGGGATGTAGTGCAATACCGCCATCGGAATGTCGTAATACTCAGCGACGTTAATGGCGAGGTCCTGGTAGAGCTGGCCGGTAAAGAGCACGTCCGCGCCGGCGGTGAGCGCGGTCAGCGTTGTGCTCATATCGGTCCATGCGCGCAGCACCGGCTCCCACGCTTCGCGCACCATGTTGATCGGCCCGCGGATGGTCCAGAATTCACGGCGTAGATCCGACCAGAAGTTGCGCAGGAATTCGTCGTCCCAGAAGGCCTGCATGTCTGGCCCGTAGGACACCGCGGAGAGCCCTGCGCCCTCCGCCAGGCCGATCAGGTTGGGCGGGATGGCCATGCGAACTTCGTGGCCTCGGCGCAGCAGTTCGCGCCCCGCCGCCAGCGAAGGCTCGACATCACCACGAGTGCCGTAACACGCCAGAGCAAATTTCATCGCGAGGCTAGCTCTATCACCTTCCCGCCGACCTAGGCAAGCTCACAGTAGCCTGTTTACAAGTGGTTCACACCGATCTTCCGCATGTCACACACCGCCGAAGATTTGCCGACGTTGTTGATTTGAGCTGACATCAGCCGATGTAATAGATGCACCAAAGGCGCTCTGTCCATTTGATACTCGAAGGCGCGCGCGGTTTTGCCCCTCAGGCGGGATGCTTTGCGCGGGCAAAGTTCTCCACGAGATCGGCGGCAGTGCTGACACTGTCGGCGGGCTTGGTCATCTGGGCCGCGAGCGCCCGCGCGCGTGTAGCGTACTCGGGGGCGAGTATCTTGCGCAGGTCCGCGACGAGCGTGTCGCGGGTCGTGCTCGAAAAGCGGCGGGCAGCGCCAACTTTGAGCCGCTTGAGCTGTGCTCCCCAGATCGTCTGATTGGGATCCATCGAGAGAATCAACGTCGGAACGCCCGCGCGCATGCTCGCGGCTGTCGTGCCCGAGCCGCCGTGGTGGACGACGGCGCGGCAGGCCGGAAACACCTTCGCGTAGTTGACGGCCCCGACCACCTTGACGTGGTCGAACTGCGGAACACCGCTGAAATCGCTCCATCCGGCGCACACCAAGGCCCGCTCACCCAACTCCGCGCAGGCGCCGCTGATCATCTCGATGGTGTCGGCCGGCGATTCCACTGGCATGCTGCCAAAGCCGAAGCAAATCGGGGGTGTGCCCGCGGCGATCCACGATGCGACCTCGTCGTCGATCTCCGTCGTCAACTCCATCGTGAGGGTACCGACGAAGGGGCGGTGGCCATTCCACTTCGCCCATTCTTCCGCTAATCCGGGAAAGCAGGCCGCGTCATAACCCTGAATTTCCAGCGACTCTCGCTCAGCGATCCGTCCCGCGGACGGGCCGGTCGCCTTCGGCAGACCGAGTTCACGCCGCTGTGCGTCCTCGACCTTCTTGTTCAGCCGCCACGTGAACCAGTCGAACACCCGCATCGCATAGCGCGCCAACGGCGGCGGCAAAAACGACACCACCTGGCCGTTGGGGCGCATCGGCACATGATGCAGCGTGACCAACGGAATGTCGTAATACTCAGCCACATTGGCCGCCGGCTCTTGATAGCTCAAGCCCGCGAAGAGCAGATCGGCTTCCTTCGCCAGCGCCACCAGCGTCGTGTTCATCTGGGTCCAGCACTGATCGCTGAGGTCCCACATCTCGCGCCACAACGTCTTGAGTTGCCGGACCCGCCAGAACCTGCTGAAAAACGAGGTCCACAAGTTGCGGTACACATCCAGCCAGGTTCGTGTGTCCAGACCGTAGGAGACCGCCGGCAGTCCGGCCGCCTCGACAAACTCCATCAAGTCGGGCGCGACTGCCATCTGCACGTCGTGTCCACGGCGCTGCAGTTCGCGGGCGACCACCAGGGACGGCTCGACATCGCCCCGCGTTCCGTAATTTGCCAGCACGAATTTCATTGTGGTTCCAGGCCTTACGGTTGTGCGCCGGTCAGGGCTTGCGCCACAGCACACCCGTGCCGTCGATCTCTACGATCTCGGCGGTGATCCCGTGCTTCTCTCGGTAGTCGGCCACGGCCTGTTCGCACGCACTAAACACGTGGTAGTCGTCGATGATGCAGAAGCCGCCGGAGGACAACCGCGGATACAAGGCATCCAAGGCCTGAATCGTCGACTCATACAGGTCACCATCAAGGCGCAACACCGAGATCTGCTCGATCGGCGCATTGGCCAACGTGTCCTTGAACCACCCCGGCACAAAACGAACCTGATCGTCCAAGAGCCCATAACGCTCGAAGTTCGCCCGGACCTCAGTCTCCGAGACACCGAGCACTCTGGCGTGCCGGTGCAGCCGAATCCCTTTATCCGCCTTGTAGTTCGCCGTATCGGGCGGCGGCACCCCCTCGAAGGAATCACACAGCCACACCCGCCGCGTCTGATCCCCGTAGGCCGCCAGCACCGCGCGCATCAAGATGGACGCCCCGCCACGCCACACCCCGCACTCCACCAGATCACCGGGCACGTTGTCGGCCAGCACCGTCTCCACACAATGCTGCAAACTGGTCAGCCGCTGCATCCCGATCATCGTCAACGCATCGGCCGGCCAATCCAGACCCCGATCCCGCGCCTGCGCATTGAACGGGCGCTTGCGCACCAACATGAAATTGCGCGTACTGAACAGTGCCCGCCCGAGCCAATGCAATCCCACCGGCACCAGCTCATCCTGACCAAAACGGGTCAGGTCACGACGGAGCAGATCAAGATACGCGGACCGCGAGTCGGTTTCCGCCACGGTCAAGATTGCCCCTCTCCTCGCATACCACCACTCCCAGCCCAGGAGCCTAGACGCCCGACCACGCCCGCAACGCGTTTCACGGATTTTCCGTTACCGTCGCGACACGCCGGCGCTTGCCGGAATGCACTGGGCAAACCAATGTGCAAGCACTTCCTCAGCTCTGGTCACGCGCAAGCAAAGATACCGATCGCCGCCAGGAAACGTAAATTCGTGTGGGGCCGCCTTCGAGGTGTCCGCCTAGCGTCCGGGCCTCAGCTTTCCCAAGCCGGTGATCTCGAGGCTGACCGACTTGCGGGAGCCAACGGCGCCGAGCAGGAACAGCATGTCTCCCAACGGCGCTCCCAGCCAGAACCGCCAGAACGGCTTGCGGAAGCATATCGAGGCGAAACGGCCCTCCCCCAGGAGCCAGAAAATAGGAATCGCGACGGCGTAGTAGAGCATGCGCATCCAGCGTGACCGGACCATCTCGATATTCATTTCCATCATTTCCAGGCCCCACGCGCGATAGTTCCATTCCAGCTCGTAGCGGCTCTGGAACTCATAGAACGCCCGCATCTCGCCATTGGTGACCAGATACTCGTCGAAAACAAGGATGGAACCCACCACGAAACGCTCCTTGCACGTTTCCAGGGCGTGCAGGCAACTCTCATAGGTGTCCAAGTCCATGTGGAAAAGCCTGATCGGGGCGCCGGGATGCTCGGCCAGGAACGGGGCCAATGTGTCGTAGGTGCTGCCCTTGATGAACTGCACTTTCCGACCAAGCGCCGCCGGCAGGCCGTCCTCCTGGAACACCACCCCGGTGTCGCGGATGAAGCGTTGAGCAAACGGGTCCGACAGTGAGAAGGTGCCCCGTTTGACGACTTGGTCTTCGAGTTTCCAGTCTTCGACCAGCCCTTCGAAACTGTCGAACCCGTAGACCATGCGACCGCTGGCATCCGAGATCAGCCGTGTGGACCAGCCGAGCCAGACACCCAGGTCAAGCAGTAGTTCGTCGGAATCTCCGAGGGTCGGCCCCGCCAGGGTCGACGCCTCGGTCAGCAGGGTATGTCCAGGGATCCGGTGCGTCCGCAATTCAGCCATGGTGCGGCGGATAAATGCGCGATAGCTCTCGTCATAAACCCTTATGTCGCGGGCATACAGATTGGGGATGTAGCGATCGCGCCCCGGATATACCAGGCGCGCAGCCAAGAGCAGCAAAATGAGTGCACCGAGCACCACCGCGAGGATCGGCGCGAAGAAGCATGCGGCGGCGGTCACGCAAGCAAAGGCAGCCAGGGTGGTCTTCCACAGACGATGAACGGTCGTCCGATCCACTGTCTTCCTATCGACCGCGACACCACCGCCCACCGGTCCACCTCCCTGTTCTCGGGCTAGATTAAGTCCAACCAGCCCGAATTATTGATGAATCACACGATTGCGTGAACAGGCACACGTCCTCACCGGCGCTGCCGATTTTGACGCCGGACGGGTGAAGTGATCGACCGCTCGACTATTTGCTGGGAAAGCTTGCCGTCGAGGCCGATTCGAGACGCTCGCCGATCCAATCAAGGAGCACCCGCAAGCCGTCGTCGAGCGACCATTTGGGGTGCCACCCCAGCTCGCTTTGCGCCGGCCCGATATCGCAACTCGCCGCACGCACGTCGCCATCACGGAATCGCCCGGTGATTACGGGTTGCGGAGCGCCGAAGTGTGCGGCGATCTTGTGGGCCAGCTCGTGAATCGTCGTGGCAATCCCCGACCCGATGTCGAGGCGACGCGAGCCGGTCGCCGGATCCTCCACAACGGCGAAGAGCGCGTCGACGACGTCCTCGATGTAAACGAAATCGCGCACGATGCGGCCATCTTCATAGACGTCAGAGGGGCGCTGTTCGCGGGACACCTGCGCGAAAAACGGGACGACGCCGGTGTACGGATTGGTCAGCGATTGACCCGGGCCATAGACGTTCTGCAGGCGCAGCACGCTCAGGTTGGTGTCGTGCGCGGCCGACCAGGACGCCAGGATGTGCTCCTGGGCCAGCTTGGTGGCGGCATAGATGTTGCTCGGCCGCGGCTCGGTCCGCGCCGCGCAGCTCGGCAGCGACACTGCAGGTTCCCCGCCCGGGCCCGGCGGATCCCACACGCCCGCGACCAGCTGTGCGTGGCTGCGCGCGCCCGGGTAGAACACCTCCGAGCCGCATTGCCAGGCGCCCTCGCCGTAGACGGCCCGCGACGACGCCAGCACCAGCTGCGCAGGCACCAATCCGGCGCGGCTCAGCGCGTCGACCAGCTGGGTGGTCCCCACCACGTTCACCGAGCCGTGGCGCGTCGCGTGCGACAGCGATTGGGCCGTGCCCGTCTCGGCAGCCAGATGGACGATCTGGTCAGGCCGGAAAAGCCGGAGCACGGCATCGCAGTCAGGACCGTGCGTGACGTCGCCGGTGAACAGGCGCACAGCGGACGGCAGGTCCGGCGCCTGCCCGGCCGCGTGCACCTGCGGGTGCAGGACATCCATCACAGCGACATCGTGACCGGCCTTGACCAGTCGGTGCGAAAGCGCGGAACCGATGAATCCAGCGCCACCAGTGATTAGCAC

Protein sequences of DBSCAN-SWA_1

>NZ_AP022568|223131:230360|224183_225479_-|WP_101528820.1|DBSCAN-SWA
MKFALACYGTRGDVEPSLAAGRELLRRGHEVRMAIPPNLIGLAEGAGLSAVSYGPDMQAFWDDEFLRNFWSDLRREFWTIRGPINMVREAWEPVLRAWTDMSTTLTALTAGADVLFTGQLYQDLAINVAEYYDIPMAVLHYIPMRPNGQLIPNLPSPLVRAGMTAYDWLVWRMNKKAEDEQRRKLGLPKTTSSSPRRIANLGSLELQAYDEVCFPGLAAEWSKWGDRRPFVGTLTMGLTTDSDDDVLSWIAAGTPPICFGFGSMPVTESPADTIEMISGACEELGERALICAGWSDFSDVPHFDHVKVVGAVNYATTFPACRAVVHHGGSGTTAAGLRAGIPALILWTAGDQPFWGGHLKKLKVGAGRRFSATTKETLVEDLRQILAPEYALRARELATRMTTAQQSVTRAADLLERFGQAGRFPVRRRHA
>NZ_AP022568|223131:230360|226984_227791_-|WP_163771433.1|DBSCAN-SWA
MTVAETDSRSAYLDLLRRDLTRFGQDELVPVGLHWLGRALFSTRNFMLVRKRPFNAQARDRGLDWPADALTMIGMQRLTSLQHCVETVLADNVPGDLVECGVWRGGASILMRAVLAAYGDQTRRVWLCDSFEGVPPPDTANYKADKGIRLHRHARVLGVSETEVRANFERYGLLDDQVRFVPGWFKDTLANAPIEQISVLRLDGDLYESTIQALDALYPRLSSGGFCIIDDYHVFSACEQAVADYREKHGITAEIVEIDGTGVLWRKP
>NZ_AP022568|223131:230360|228025_229135_-|WP_044511474.1|DBSCAN-SWA
MGGGVAVDRKTVDRTTVHRLWKTTLAAFACVTAAACFFAPILAVVLGALILLLLAARLVYPGRDRYIPNLYARDIRVYDESYRAFIRRTMAELRTHRIPGHTLLTEASTLAGPTLGDSDELLLDLGVWLGWSTRLISDASGRMVYGFDSFEGLVEDWKLEDQVVKRGTFSLSDPFAQRFIRDTGVVFQEDGLPAALGRKVQFIKGSTYDTLAPFLAEHPGAPIRLFHMDLDTYESCLHALETCKERFVVGSILVFDEYLVTNGEMRAFYEFQSRYELEWNYRAWGLEMMEMNIEMVRSRWMRMLYYAVAIPIFWLLGEGRFASICFRKPFWRFWLGAPLGDMLFLLGAVGSRKSVSLEITGLGKLRPGR
>NZ_AP022568|223131:230360|223131_223938_-|WP_163771431.1|DBSCAN-SWA
MTVTETDARSAYLDLLRRDLTRYGQDELVPVGWYRLGRPIFNTRNFMLVRKRPFNAHARDRGLDWPADALTMIGMQRLTSLQHCVETVLADNVPGDLVECGVWRGGASILMRAVLAAYGDQTRRVWLCDSFEGVPPPDTVNYKADKGIRLDRHANVLGIPESVVRANFERYGLLDDQVRFVPGWFKDTLANAPIEQISVLRLDGDLYESTIQALDALYPRLSSGGFCIIDDYHALKPCEQAVADYREKHGITAEIVEIDGTGVLWRKS
>NZ_AP022568|223131:230360|225684_226953_-|WP_044511476.1|DBSCAN-SWA
MKFVLANYGTRGDVEPSLVVARELQRRGHDVQMAVAPDLMEFVEAAGLPAVSYGLDTRTWLDVYRNLWTSFFSRFWRVRQLKTLWREMWDLSDQCWTQMNTTLVALAKEADLLFAGLSYQEPAANVAEYYDIPLVTLHHVPMRPNGQVVSFLPPPLARYAMRVFDWFTWRLNKKVEDAQRRELGLPKATGPSAGRIAERESLEIQGYDAACFPGLAEEWAKWNGHRPFVGTLTMELTTEIDDEVASWIAAGTPPICFGFGSMPVESPADTIEMISGACAELGERALVCAGWSDFSGVPQFDHVKVVGAVNYAKVFPACRAVVHHGGSGTTAASMRAGVPTLILSMDPNQTIWGAQLKRLKVGAARRFSSTTRDTLVADLRKILAPEYATRARALAAQMTKPADSVSTAADLVENFARAKHPA
>NZ_AP022568|223131:230360|229277_230360_-|WP_044511472.1|DBSCAN-SWA
MLITGGAGFIGSALSHRLVKAGHDVAVMDVLHPQVHAAGQAPDLPSAVRLFTGDVTHGPDCDAVLRLFRPDQIVHLAAETGTAQSLSHATRHGSVNVVGTTQLVDALSRAGLVPAQLVLASSRAVYGEGAWQCGSEVFYPGARSHAQLVAGVWDPPGPGGEPAVSLPSCAARTEPRPSNIYAATKLAQEHILASWSAAHDTNLSVLRLQNVYGPGQSLTNPYTGVVPFFAQVSREQRPSDVYEDGRIVRDFVYIEDVVDALFAVVEDPATGSRRLDIGSGIATTIHELAHKIAAHFGAPQPVITGRFRDGDVRAASCDIGPAQSELGWHPKWSLDDGLRVLLDWIGERLESASTASFPSK

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_163771431.1|223131_223938_-	class I SAM-dependent methyltransferase	A0A2R8FDY2	Brazilian_cedratvirus	9.2e-55	51.4
WP_101528820.1|224183_225479_-	glycosyltransferase	A0A1L3KK54	Shahe_endorna-like_virus	2.3e-07	40.6
WP_044511476.1|225684_226953_-	glycosyltransferase	A0A1L3KK54	Shahe_endorna-like_virus	3.3e-06	40.3
WP_163771433.1|226984_227791_-	class I SAM-dependent methyltransferase	A0A2R8FDY2	Brazilian_cedratvirus	1.9e-55	52.4
WP_044511474.1|228025_229135_-	class I SAM-dependent methyltransferase	A0A2H4UUT3	Bodo_saltans_virus	1.2e-12	31.4
WP_044511472.1|229277_230360_-	NAD-dependent epimerase/dehydratase family protein	L7RCI0	Acanthamoeba_polyphaga_moumouvirus	6.2e-14	23.9