CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_AP022571	Mycolicibacterium poriferae strain JCM 12603 plasmid pJCM12603, complete sequence	0 crisprs	csa3	0	0	1	0
NZ_AP022570	Mycolicibacterium poriferae strain JCM 12603	7 crisprs	DEDDh,csa3,WYL,cas3,c2c9_V-U4,casR,DinG	0	0	2	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

118295 : 199847

Mycobacterium_phage(53.33%)

protease,transposase,integrase

attL 118326:118345|attR 209595:209614

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_159232845.1\|118295_119216_+\|protease	M48 family metalloprotease	NA	NA	NA	NA
118326:118345	attL	NA	NA	NA	NA
WP_163681282.1\|119604_120336_+	winged helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_163681183.1\|120399_121170_-	NlpC/P60 family peptidoglycan endopeptidase RipB	A0A1J0GW44	Streptomyces_phage	1.2e-16	44.0
WP_163681185.1\|124711_125695_-\|transposase	IS481 family transposase	A0A0M3LS26	Mannheimia_phage	2.2e-10	31.1
WP_170311247.1\|126113_127196_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_163681191.1\|128476_129334_-	hypothetical protein	NA	NA	NA	NA
WP_159233604.1\|129758_130994_-\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	7.2e-83	43.9
WP_163681193.1\|131514_131763_-	hypothetical protein	NA	NA	NA	NA
WP_115329250.1\|133402_134494_+	hypothetical protein	A0A1J0MBM2	Mycobacterium_phage	2.9e-27	48.0
WP_115329229.1\|134534_135623_+	C40 family peptidase	A0A249XSM6	Mycobacterium_phage	6.2e-22	45.2
WP_115329230.1\|135919_137839_+	DUF4226 domain-containing protein	NA	NA	NA	NA
WP_115329231.1\|137901_138210_+	hypothetical protein	NA	NA	NA	NA
WP_115329232.1\|138196_138505_+	DUF2694 family protein	NA	NA	NA	NA
WP_115329233.1\|138509_140174_+	PPE domain-containing protein	NA	NA	NA	NA
WP_115329234.1\|140173_140506_+	hypothetical protein	NA	NA	NA	NA
WP_115329235.1\|140987_141644_+	hypothetical protein	NA	NA	NA	NA
WP_115329251.1\|141665_144194_+	chemotaxis protein	NA	NA	NA	NA
WP_011767961.1\|144208_144724_+	hypothetical protein	NA	NA	NA	NA
WP_163681197.1\|144840_148998_+	type VII secretion protein EccCa	V5UPA0	Mycobacterium_phage	2.9e-91	27.1
WP_163681199.1\|149201_149510_+	PE domain-containing protein	NA	NA	NA	NA
WP_163681202.1\|149525_150767_+	PPE domain-containing protein	NA	NA	NA	NA
WP_163681204.1\|150848_151169_+	hypothetical protein	NA	NA	NA	NA
WP_048424368.1\|151210_151507_+	hypothetical protein	NA	NA	NA	NA
WP_163681206.1\|151606_152473_+	ESX secretion-associated protein EspG	NA	NA	NA	NA
WP_163681208.1\|152550_154068_+	type VII secretion protein EccB	V5UN45	Mycobacterium_phage	5.2e-75	38.2
WP_163681209.1\|154134_155742_+	chromosome partitioning protein	NA	NA	NA	NA
WP_170311248.1\|155798_157256_+	type VII secretion integral membrane protein EccD	NA	NA	NA	NA
WP_163681213.1\|157255_158923_+	S8 family serine peptidase	A0A0A7HDD8	Mycobacterium_phage	2.0e-72	37.1
WP_163681216.1\|158919_160623_+	type VII secretion protein EccE	NA	NA	NA	NA
WP_163681219.1\|160619_161480_+	hypothetical protein	NA	NA	NA	NA
WP_163681222.1\|161537_161804_+	hypothetical protein	NA	NA	NA	NA
WP_163681225.1\|161860_163273_+	TraM recognition domain-containing protein	V5UN59	Mycobacterium_phage	2.6e-20	37.6
WP_163681228.1\|163269_163599_+	hypothetical protein	NA	NA	NA	NA
WP_163681232.1\|163764_164421_+	hypothetical protein	V5UQM8	Mycobacterium_phage	2.8e-09	29.0
WP_170311249.1\|164435_164942_-	hypothetical protein	NA	NA	NA	NA
WP_163681238.1\|165031_165391_+	hypothetical protein	NA	NA	NA	NA
WP_163681240.1\|165383_166505_+	hypothetical protein	NA	NA	NA	NA
WP_163681242.1\|166519_167434_+	conjugal transfer protein	NA	NA	NA	NA
WP_011767719.1\|167460_167751_+	hypothetical protein	NA	NA	NA	NA
WP_163681245.1\|167755_168103_+	hypothetical protein	NA	NA	NA	NA
WP_163681247.1\|168116_170705_+	ATP-binding protein	NA	NA	NA	NA
WP_163681249.1\|170701_172729_+	hypothetical protein	NA	NA	NA	NA
WP_163681251.1\|172753_174535_+	type VII secretion AAA-ATPase EccA	V5UQM2	Mycobacterium_phage	1.5e-57	32.2
WP_163681284.1\|174636_174843_+	transcriptional regulator	NA	NA	NA	NA
WP_163681286.1\|174853_177832_-	Helicase associated domain protein	A0A1V0SHP4	Klosneuvirus	5.7e-25	26.7
WP_163681253.1\|178017_179964_-	helicase	NA	NA	NA	NA
WP_163681255.1\|179884_181939_-	DUF87 domain-containing protein	NA	NA	NA	NA
WP_165645377.1\|181950_182805_-	SIR2 family protein	NA	NA	NA	NA
WP_074338999.1\|183779_184502_-	M48 family metallopeptidase	NA	NA	NA	NA
WP_074339000.1\|184488_187575_-	HsdR family type I site-specific deoxyribonuclease	A0A220A398	Liberibacter_phage	3.7e-59	29.8
WP_074339001.1\|187571_188798_-	restriction endonuclease subunit S	NA	NA	NA	NA
WP_074339002.1\|188794_191230_-	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	2.4e-74	36.4
WP_074339003.1\|191371_191785_-	hypothetical protein	NA	NA	NA	NA
WP_074339004.1\|191781_193926_-	hypothetical protein	NA	NA	NA	NA
WP_074339005.1\|193922_195743_-	hypothetical protein	NA	NA	NA	NA
WP_044482876.1\|195828_196626_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	3.2e-23	32.5
WP_074338941.1\|196627_198250_-\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_074338825.1\|198374_199847_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
209595:209614	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_AP022570

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CRISPR-Cas detection and classification

Crispr_ID: NZ_AP022570_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022570_1

447259-447440

Orphan

Consensus_repeat	Method
GACGGCACCGCAGGCGGCGAAGGCCCGGCCGACGGCGGCTCGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022570_1

>merge|NZ_AP022570|1|447259-447440|CRISPRCasFinder
ACCTCCACCGGCGGCGGCGAGGGGGTCGCTGACGGCGGCTCGAACCCGGGCGGCCACGACGGTGGAGCCGACGGCACCGCAGGCGGCGAAGGCCCGGCCGACGGCGGCTCGAATCCTCAGGGCCACGACGGCGGCGCGGACGGCACCGCAGGCGGCGAAGGCCCGGCCGACGGCGGCTCGAA

>NZ_AP022570|1|1|447259-447440|CRISPRCasFinder
ACCTCCACCGGCGGCGGCGAGGGGGTCGCTGACGGCGGCTCGAA	CCCGGGCGGCCACGACGGTGGAGCCGACGGCACCGCAGGCGGCGAAGGCCCGGCCGACGGCGGCTCGAATCCTCAGGGCCACGACGGCGGCGCG
GACGGCACCGCAGGCGGCGAAGGCCCGGCCGACGGCGGCTCGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022570.1\|WP_163679721.1\|455647_455845_-\|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl\|CDD\|379915
NZ_AP022570.1\|WP_163672286.1\|454692_455604_-\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187539
NZ_AP022570.1\|WP_163672287.1\|455963_456995_+\|MaoC-family-dehydratase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|184249
NZ_AP022570.1\|WP_163672281.1\|448701_449592_+\|sucrase-ferredoxin	unknown	unknown	gnl\|CDD\|227101
NZ_AP022570.1\|WP_163672274.1\|443990_444983_-\|glycoside-hydrolase-family-6-protein	unknown	unknown	gnl\|CDD\|227616
NZ_AP022570.1\|WP_163672278.1\|446864_447104_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022570.1\|WP_163672271.1\|441226_441865_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_AP022570.1\|WP_163672280.1\|447490_448705_+\|cupin-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|369647
NZ_AP022570.1\|WP_163672276.1\|445487_445922_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_AP022570.1\|WP_163672277.1\|445973_446753_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|184875
NZ_AP022570.1\|WP_163672282.1\|449616_450315_+\|proteasome-protein	unknown	unknown	gnl\|CDD\|223711
NZ_AP022570.1\|WP_163672272.1\|442755_443301_-\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|130981
NZ_AP022570.1\|WP_163672285.1\|452690_454688_+\|DUF1214-domain-containing-protein	unknown	unknown	gnl\|CDD\|235906
NZ_AP022570.1\|WP_163672284.1\|451883_452549_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181126
NZ_AP022570.1\|WP_163672270.1\|440713_441151_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022570.1\|WP_163672273.1\|443383_443977_+\|ABATE-domain-containing-protein	unknown	unknown	gnl\|CDD\|227803
NZ_AP022570.1\|WP_163672275.1\|445031_445451_-\|DoxX-family-membrane-protein	unknown	unknown	gnl\|CDD\|226720
NZ_AP022570.1\|WP_163672283.1\|451191_451719_+\|hemerythrin-domain-containing-protein	unknown	unknown	gnl\|CDD\|213983
NZ_AP022570.1\|WP_163679715.1\|441913_442678_-\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|274926
NZ_AP022570.1\|WP_163679717.1\|450401_451151_+\|adenylate/guanylate-cyclase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143636

Protein	Function_ID	Function_description	E-value
NZ_AP022570.1\|WP_163679721.1\|455647_455845_-\|zinc-ribbon-domain-containing-protein	gnl\|CDD\|379915	pfam17032, zinc_ribbon_15, zinc-ribbon family. This zinc-ribbon region is found on a set of largely microsporidia-specific proteins.	5.72477e-05
NZ_AP022570.1\|WP_163672286.1\|454692_455604_-\|NAD(P)H-binding-protein	gnl\|CDD\|187539	cd05228, AR_FR_like_1_SDR_e, uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs. This subgroup contains proteins of unknown function related to aldehyde reductase and flavonoid reductase of the extended SDR-type. Aldehyde reductase I (aka carbonyl reductase) is an NADP-binding SDR; it has an NADP-binding motif consensus that is slightly different from the canonical SDR form and lacks the Asn of the extended SDR active site tetrad. Aldehyde reductase I catalyzes the NADP-dependent reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. The related flavonoid reductases act in the NADP-dependent reduction of flavonoids, ketone-containing plant secondary metabolites. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	5.27219e-27
NZ_AP022570.1\|WP_163672287.1\|455963_456995_+\|MaoC-family-dehydratase-N-terminal-domain-containing-protein	gnl\|CDD\|184249	PRK13693, PRK13693, (3R)-hydroxyacyl-ACP dehydratase subunit HadB; Provisional.	2.89045e-59
NZ_AP022570.1\|WP_163672281.1\|448701_449592_+\|sucrase-ferredoxin	gnl\|CDD\|227101	COG4759, COG4759, Uncharacterized protein conserved in bacteria containing thioredoxin-like domain [Posttranslational modification, protein turnover, chaperones].	4.57648e-27
NZ_AP022570.1\|WP_163672274.1\|443990_444983_-\|glycoside-hydrolase-family-6-protein	gnl\|CDD\|227616	COG5297, CelA, Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism].	1.02519e-81
NZ_AP022570.1\|WP_163679717.1\|450401_451151_+\|adenylate/guanylate-cyclase-domain-containing-protein	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	3.44477e-35
NZ_AP022570.1\|WP_163672271.1\|441226_441865_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.84823e-13
NZ_AP022570.1\|WP_163672280.1\|447490_448705_+\|cupin-like-domain-containing-protein	gnl\|CDD\|369647	pfam08007, Cupin_4, Cupin superfamily protein. This family contains many hypothetical proteins that belong to the cupin superfamily.	1.66768e-30
NZ_AP022570.1\|WP_163679715.1\|441913_442678_-\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|274926	TIGR04025, hypothetical_protein, PPOX class probable FMN-dependent enzyme, DR_2398 family. Members of the PPOX family (see pfam01243) may contain either FMN or F420 as cofactor. This subfamily consists of proteins mostly from species that lack the capability to synthesize F420, and therefore most likely all bind FMN.	6.15302e-12
NZ_AP022570.1\|WP_163672277.1\|445973_446753_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|184875	PRK14875, PRK14875, acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional.	3.03867e-32
NZ_AP022570.1\|WP_163672282.1\|449616_450315_+\|proteasome-protein	gnl\|CDD\|223711	COG0638, PRE1, 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones].	8.7019e-12
NZ_AP022570.1\|WP_163672272.1\|442755_443301_-\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|130981	TIGR01926, peroxid_rel, uncharacterized peroxidase-related enzyme. This protein family with length of about 200 amino acids. One member, from Myxococcus xanthus, is a selenoprotein, with an otherwise conserved Cys replaced by Sec. This family is drawn narrowly enough to suggest that These proteins contain a domain described by TIGR00778, with a CxxCxxxHxxxxxxxG motif. Some members of that family are known to act as peroxidases or correlate with resistance to oxidative stress.	4.21248e-18
NZ_AP022570.1\|WP_163672285.1\|452690_454688_+\|DUF1214-domain-containing-protein	gnl\|CDD\|235906	PRK07003, PRK07003, DNA polymerase III subunit gamma/tau.	1.38156e-07
NZ_AP022570.1\|WP_163672276.1\|445487_445922_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.50993e-22
NZ_AP022570.1\|WP_163672273.1\|443383_443977_+\|ABATE-domain-containing-protein	gnl\|CDD\|227803	COG5516, COG5516, Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only].	1.13713e-08
NZ_AP022570.1\|WP_163672275.1\|445031_445451_-\|DoxX-family-membrane-protein	gnl\|CDD\|226720	COG4270, COG4270, Predicted membrane protein [Function unknown].	9.97378e-08
NZ_AP022570.1\|WP_163672283.1\|451191_451719_+\|hemerythrin-domain-containing-protein	gnl\|CDD\|213983	cd12108, Hr-like, Hemerythrin-like domain. Hemerythrin (Hr) like domains have the same four alpha helix bundle and a similar, but slightly different active site structure than hemerythrin. They are non-heme diiron binding proteins mainly found in bacteria and eukaryotes. Like Hr, they may be involved in oxygen transport or like human FBXL5 (F-box and leucine-rich repeat protein 5), a member of this group, play a role in cellular iron homeostasis.	1.90455e-06
NZ_AP022570.1\|WP_163672284.1\|451883_452549_+\|SDR-family-oxidoreductase	gnl\|CDD\|181126	PRK07806, PRK07806, SDR family oxidoreductase.	9.42603e-92

>NZ_AP022570.1|WP_163672278.1|446864_447104_+|hypothetical-protein
MLALLSSPVRRWVLTALLVPAVALVLRKIAQFLQRRNDGTPTKSSRGLMKASSGLRRLSGKKSEDADADKASEDKRLSA
>NZ_AP022570.1|WP_163672277.1|445973_446753_-|alpha/beta-fold-hydrolase
MKYQRCGSGPTLLLIHGISHRQNWSPVIPALARERDVIAVDLPGFGESPPLPGEVSVATLTDAVEEFIAEHDLGDVDIVGSSMGARMALELARRGHGGATVALDPGGFWTGAEVAYFAATVVPSIALVRRIQPVLPRLVSNRVGRTALLLQFSAKPSALDRDLVLSELRNFASSPGLFDALEALIRGPKQRGAPSGTLRAPVVIGWGRKDRVTPPRQAQRALERFPDAVLHWFSECGHFPHWDRPGETVQLILDSTGPR
>NZ_AP022570.1|WP_163672276.1|445487_445922_-|MarR-family-transcriptional-regulator
MATLRLEDQLCFALYSASRAVSSAYRPLLDELNLTYPQYLVLLVLWEDEACSIGQLGDRLHLDSGTLSPLIKRLEAAGLVRRQRSVTDERRVDVTLTADGRALEDRAACIPERLLGSTDADPAQLAALRDALTLITAEVYARNG
>NZ_AP022570.1|WP_163672275.1|445031_445451_-|DoxX-family-membrane-protein
MSELPPPPPTTRARTVARLALAGAMVFAGFSHLFWAREEFQAQVPKWVPMDPDGVVMASGGVEITLGVGLAVLNRDRVLVGRLLAAFFILIFPGNIAQYLNHADGFGLDTDTKRLVRLFFQPVLIAWALWATGIPRSKR
>NZ_AP022570.1|WP_163672274.1|443990_444983_-|glycoside-hydrolase-family-6-protein
MTFSGAAVARWIAPFLTVAAVAAVGAVSAPVHSADTPAVRLASDANPLVGMPFYVNPQSKGMRAAQGNPDPLLAAVVNTPTAYWMDHISTPAVDAKYIATAQAAGTMPILALYGIPNRDCGSYAAGGFGSAGAYRAWIDGVAAAIGTGPAAVILEPDALAMIDCLSPGQQQERLELIGYAVDTLTRNPATAVYVDAGHPRWVAADVMAGRLNQVGVQKARGFSLNTANFFTTEESMGYGQAISGMTNGAHYVIDTSRNGAGPVEGDDLYWCNPSGRALGVAPTTATGNPTVDAFLWVKRPGESDGSCRGAPSAGTFVSQYAIDLARNAGW
>NZ_AP022570.1|WP_163672273.1|443383_443977_+|ABATE-domain-containing-protein
MPDPSAQWVLPGEPMPVRLMNTVWADTAGVHDDLTTSTALRRWLTDVAGVDVGSDPSFAELTEARTLRDSLRRVAAFVTDDDRPAARSPVDSVDAAVADINDMAADQARAALLRQGDALRRESLAHAPPVRTALAGLAAEAIDLLTGASAGALRACHAPHCVLYFVKSHPRREWCSQACGNRVRAARHYRRIRSGRQ
>NZ_AP022570.1|WP_163672272.1|442755_443301_-|carboxymuconolactone-decarboxylase-family-protein
MSTTTAFTPVDPSSATGTTAELLAQVRKSLGTVPNMTAAMANSPTLLKAYLALSGAVAGGALSPAARERLAVATAQLNGCEYCLSAHTYVGAQVAKIDADELERARRGQSQDPHLAALLELSNTIAENAGDVDAEDLDRARRAGVTDEEIGELVANLALNILTNYFNVLAGVENDWPVVSL
>NZ_AP022570.1|WP_163679715.1|441913_442678_-|pyridoxamine-5'-phosphate-oxidase-family-protein
MVRPGGLTPGAATFVSGATFGALTARDRAGRLWTAPLLGQPGFVTPESSSTLRIRSGIADTDPLFDLPSGQAVGVIVIDYAARRRLRVNGHLDRSAEGELLVSIAQAYGNCPQYIPRAQWRSGLPAPHRRRVHDGDSLRDSDIDQIRRAATFILGTTHPTAGNDASHRGGPPGFVTVSPRRVRWPDYPGNNMFNSLGNLAVDPTAALMFAATSGRVVQISGEATVTWGQPAAEEPDDTGRGVEFRIDRVVVTTA
>NZ_AP022570.1|WP_163672271.1|441226_441865_+|TetR-family-transcriptional-regulator
MSADVGKREAHKIATRRAIQSAADALFEHRGYAQTTVRDIADAAGVTERTFFRYFSGKEALLVQDIEAGIPVLADEIRRRPATESPLDAVENALLVTADRLRETQPNLSWLFQDGPPGPKLAKSSPGLLFQLEQAVAEALADRMESSRPLTDDAEFEAQVLARCAVAALRSTGIRRWQLERRGDTGVSETRLLAQAFAIVRRGGPADRRPRR
>NZ_AP022570.1|WP_163672270.1|440713_441151_-|hypothetical-protein
MTDFWRRVPRHHLIRVGYGVAGLKIGTLWMAQGDSSPAEHAVHLMALLVAIMAVTDVARRLAARRGRRVAHHPIGRFLLAKTAVVGLAVVAGIVVDGWLPHTELWVGAGLVVLIGAVGPLLHPWLINAARPAPTRMVDEPVLVAA
>NZ_AP022570.1|WP_163672280.1|447490_448705_+|cupin-like-domain-containing-protein
MLSRCVATDTHTFATTYWGRAPLLSSADALPRDFSDLLSPDAVDELIAERGVRSPFIRLAKEGDLLAKDCYLGPAGFGAEMPDQVDSAKVLGEFASGATIVLQGLHRLWPPVIDFVRQAVDELGHPVQANAYVTPPDSRGFDFHYDVHDVFVLQASGHKRWVVHDPVHAHPLPSQPWTQHRAAIAERVEADPVIDKVLGPGDALYLPRGWVHAAQAQDTTSIHLTVGVAAVTGLDVAKAVIEQLADDETFRRSLPMGGAPTDRDGIIPAVTKVMAQMVDRLRDDATALSTGAATHLTRRHAERTRPAAVRPLATLDAAARADTTSVRWRHALPAAVENADGRVVLRLPDRLMTFPMSCAPALAALHGGLVVTAASTPGLDPADATVLIRRLLREGVVVPAAADR
>NZ_AP022570.1|WP_163672281.1|448701_449592_+|sucrase-ferredoxin
MSRKKVPCSDQSLARGDPMYGTASAGSNWLLLELSGAWGPSAFLQSPAIIDPALGRTVVRRAEKAGMRIAAIRRHGRRPATPRWRWYVARAEPGAEALYRGEVDDPHAYADLALDGSDGEPSAGPLIAVCAHGTHDQCCAVRGRSACRAIAQEFPENTWECSHLGGDRFAATMLVLPEGLCYGRVDTTDSAGLVRRYLDGRLDNRFLRGRTSLPHAVQAAQYFAREQSGEDRIDALAPLHVERGDGHILVTLNGKAGPIEVTLEEQLSEPLLSQCHAEVAGQVRVFTCAALAPVAG
>NZ_AP022570.1|WP_163672282.1|449616_450315_+|proteasome-protein
MTVVLALRCADGLVLAADSQITEPDRGLSYPAQKLHGLGRRAAWAGSGSRAVLYDLEQIFDSQPETIVEAGDVGRALQTRVVPVLQHHYENFIEDVPGQEKSGSTPATYVLAAGYSDGKPFMVDVDPHGLIGHYEEIGFHAIGSGAPMAQQARALLANFRMNERPVEYGVLAALRVLDALDETSPTVGGPMDVCRITTDGADHLAPEDIDKARAEVRRWQDRERDVLDTLFG
>NZ_AP022570.1|WP_163679717.1|450401_451151_+|adenylate/guanylate-cyclase-domain-containing-protein
MRRKLTSARRALRARPTRSAESRPRRRPRGVAPLAVKTVVDTVQTADSLIRKGLGGSIRHSIDDLAGWARVERPDLARITADGSVVLLFSDIEDSTRHNQTLGDRDWITVLERHNKLVERSVSAHGGYVVKNQGDGFMIAFADPAKALRCSLDVQRALGGDTERWNGIRVRIGAHAGTSVRRGHDLFGLDVVMAARIADLARGGEILVSAALRDSVADADGFCFTTGREVRLKGITDAQTVHALAMPAS
>NZ_AP022570.1|WP_163672283.1|451191_451719_+|hemerythrin-domain-containing-protein
MADIIELIYADHDWLRRQFFRLDDATSDAELQAIWSVLSARLDAHAEAEEAVFYPALLKHGGREDPGNPEGDPQDETEDAITDHNDIRDAVRESRRHEPGSAQWFEAVNTARKENGSHLDEEEREAMPDFIKSATLELRHQLGTQWLRFYAERESLEGVDNRDKDADEYIEEHSP
>NZ_AP022570.1|WP_163672284.1|451883_452549_+|SDR-family-oxidoreductase
MPLGPERIVLITGASRGIGAQVALQLATPGTHVLVNHRKSGDRAASIAQAIRDVGGQASTIAADISEEADVTAMMETIRARFGRLDALILNASDGRETGADPEYAMRLNRDAQKRLATLAMPLMPAGARIVFVTSHQAHFFPHKAVPKGYAAVAVSKRAGESALYAMRPEFVRAGIGFTVVSGDMVDDTIVMRAAAIAQAATTAPSPGIVYVGRADYLTTA
>NZ_AP022570.1|WP_163672285.1|452690_454688_+|DUF1214-domain-containing-protein
MRRSSEPAAQQQPRPALGYAKFIGRVGALAVFLGVGSALAVPAAHADTDGASSAESSSESASSSSTGEASSGSTESSSVSTSSATEAEAEDPDAEAAEAESEAEAEAEAEAEAEEAADAEVDTESGDDVADESALDATVTVARTVEAPAASDARSDAGSDADDPEVPAAAPAVPAPAPRRLAATETPVVTEQQTLSADAALSNQVSPLGTPQQIEREKIAMSTAKSLPVALMKIILRFGFLAAAKEQFALVGGPDAANREALDNAIDEYALAASFQQQILNPLDPAVVTQVAPPHSWYGIDVGGSRLLYDNPDTIYRFIAVNKTSEYVLTGRIYDGIPADTTFSVLEGTAGTTSTILTLSDLDINDDGSFVITVSGDPAAPGQTNHLQLTSRSTLIAARNTLGDWNVEDPMELAVQRVAGPRNSLFAQLGGFVLLGGLVNDSPFLTSLVSLIPPLGIAEWRPVRGTLAALLLLVRGANEQAKYMALATTDPDTGELRQPNVMTQPASNAEFLANQLQSNGYFQLADDEALVLTIDPGNAGFFTVPVYNDWTITDDYWNEQTSLNDDQSIANADGTYTMVVSVADPGVANWVSTGGLNQGIISMRFQNLDPQSPAVPSVQSVVVKLEDLEDELPAGTVFVTPQERAAQLAARKAGYDKRWAPYPQV
>NZ_AP022570.1|WP_163672286.1|454692_455604_-|NAD(P)H-binding-protein
MTSTQSLTVVVTGANGFVGARTCAALVERGARVRAVVRRAGAAPRLDGVEERIGDFGDPAFAAEVVDGTRAVVTTVHPMGSDRRTQHRVAVEGTPVIASAARDAGVDRLVHMSTAGVYDRSPGVGDVDESAALVGDDGGDYPVTKRDTDAALADVDGITRVLVRPPAILGPGATSIWNTLRPNEMADSGAAHRTNPAKTFAWVHVDDLAALLADLATGRIATSTDLQQGPIEGGCSVVNAAGEAATQRDYLTAVTDALGIEPAWDDEPAWTGQIVADRARGWGWTPRVSLMQALDELRDGLRR
>NZ_AP022570.1|WP_163679721.1|455647_455845_-|zinc-ribbon-domain-containing-protein
MFLLFGYGTKQKALGPGEVRTCPRCHNTTQWTRMRQFKQFTLFFIPVARWSRRQFEVCGICGASV
>NZ_AP022570.1|WP_163672287.1|455963_456995_+|MaoC-family-dehydratase-N-terminal-domain-containing-protein
MTTAAEATQLEARVGHWYRMDDTYLVGREKLREYARAVQDYHPAHWDVAAAADLGYPDLVAPLTFTSTPGMTCNRRMFEEIVVGYDTWMQTEEVFEQHRPIVAGDELTIDVELTSVRRIAGRDLVTVTNTFTDTAGERVHTLHTTVVGVTAEDVDPAIKTAVHNAMMHDVNILAVGQSDTAYEKTVRPEGEVRISEGAFTRTPGTPSFDEVKVGDELPPHHARLSRGDLVNYSGVAGDANPIHWDEDIAKLAGLPDVIAHGMLTMGLGAGFASAWSGDPGAVTRYAVRLSAPAVVSAKEGADIEYSGRIKSLDPETRSGVVLVAAKSEGKKIFGLATMHVRFR

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Crispr_ID: NZ_AP022570_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022570_2

628325-628447

Orphan

Consensus_repeat	Method
CGCCGAGCGTGAACTGCTTGCGATTTTTGAGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022570_2

>merge|NZ_AP022570|2|628325-628447|CRISPRCasFinder
CGCCGAGCGTGAACTGCTTGCGATTTTTGAGCCCGGTTTTTCGTAAAGGATTCACAACCGGCGAAACGTCTGGCGAGAGGATCGGCGCGTCGCCGAGCGTGAACTGCTTGCGATTTTTGAGCC

>NZ_AP022570|2|2|628325-628447|CRISPRCasFinder
CGCCGAGCGTGAACTGCTTGCGATTTTTGAGCC	CGGTTTTTCGTAAAGGATTCACAACCGGCGAAACGTCTGGCGAGAGGATCGGCGCGT
CGCCGAGCGTGAACTGCTTGCGATTTTTGAGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022570.1\|WP_163672447.1\|629308_630670_+\|cation:dicarboxylase-symporter-family-transporter	unknown	unknown	gnl\|CDD\|366058
NZ_AP022570.1\|WP_163672440.1\|622413_623625_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225306
NZ_AP022570.1\|WP_152514854.1\|633382_634237_-\|2-aminoethylphosphonate-ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|237888
NZ_AP022570.1\|WP_163672449.1\|631125_632574_+\|amino-acid-carrier-protein	unknown	unknown	gnl\|CDD\|376500
NZ_AP022570.1\|WP_163672445.1\|625998_626490_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NZ_AP022570.1\|WP_163672444.1\|625294_625996_+\|phosphodiesterase	unknown	unknown	unknown
NZ_AP022570.1\|WP_163672434.1\|615508_616918_-\|FtsW/RodA/SpoVE-family-cell-cycle-protein	unknown	unknown	gnl\|CDD\|223843
NZ_AP022570.1\|WP_163672437.1\|619098_620493_-\|DUF3662-domain-containing-protein	unknown	unknown	gnl\|CDD\|378850
NZ_AP022570.1\|WP_163672451.1\|632575_633373_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|132299
NZ_AP022570.1\|WP_163672453.1\|634233_635403_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|226361
NZ_AP022570.1\|WP_163672457.1\|636447_637131_-\|phosphonatase-like-hydrolase	unknown	unknown	gnl\|CDD\|274534
NZ_AP022570.1\|WP_163672455.1\|635404_636445_-\|2-aminoethylphosphonate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|237887
NZ_AP022570.1\|WP_152514849.1\|628762_629134_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|380093
NZ_AP022570.1\|WP_163679758.1\|626735_628214_-\|fused-MFS/spermidine-synthase	unknown	unknown	gnl\|CDD\|223498
NZ_AP022570.1\|WP_163672442.1\|623757_625248_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224983
NZ_AP022570.1\|WP_163672438.1\|621092_622373_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NZ_AP022570.1\|WP_152514838.1\|618440_618908_-\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|224630
NZ_AP022570.1\|WP_163672459.1\|637134_638250_-\|TIGR03364-family-FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|132407
NZ_AP022570.1\|WP_152514851.1\|630687_630954_+\|YdeI/OmpD-associated-family-protein	unknown	unknown	gnl\|CDD\|379149
NZ_AP022570.1\|WP_163672435.1\|616914_618444_-\|protein-phosphatase-2C-domain-containing-protein	unknown	unknown	gnl\|CDD\|223704

Protein	Function_ID	Function_description	E-value
NZ_AP022570.1\|WP_163672437.1\|619098_620493_-\|DUF3662-domain-containing-protein	gnl\|CDD\|378850	pfam12401, DUF3662, Protein of unknown function (DUF2662). This domain family is found in bacteria, and is approximately 120 amino acids in length. The family is found in association with pfam00498.	2.87483e-51
NZ_AP022570.1\|WP_163672440.1\|622413_623625_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225306	COG2508, COG2508, Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism].	1.09766e-55
NZ_AP022570.1\|WP_152514854.1\|633382_634237_-\|2-aminoethylphosphonate-ABC-transporter-permease-subunit	gnl\|CDD\|237888	PRK15050, PRK15050, 2-aminoethylphosphonate transport system permease PhnU; Provisional.	1.7156e-121
NZ_AP022570.1\|WP_163672449.1\|631125_632574_+\|amino-acid-carrier-protein	gnl\|CDD\|376500	pfam01235, Na_Ala_symp, Sodium:alanine symporter family.	0
NZ_AP022570.1\|WP_163672445.1\|625998_626490_-\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	5.83698e-09
NZ_AP022570.1\|WP_152514851.1\|630687_630954_+\|YdeI/OmpD-associated-family-protein	gnl\|CDD\|379149	pfam13376, OmdA, Bacteriocin-protection, YdeI or OmpD-Associated. This is a family of archaeal and bacterial proteins predicted to be periplasmic. YdeI is important for resistance to polymyxin B in broth and for bacterial survival in mice upon oral, but not intraperitoneal inoculation, suggesting a role for YdeI in the gastrointestinal tract of mice. Production of the ydeI gene is regulated by the Rcs (regulator of capsule synthesis) phospho-relay system pathway independently of RcsA, and additionally transcription of the protein is regulated by the stationary-phase sigma factor, RpoS (sigma-S). YdeI confers protection against cationic AMPs (Antimicrobial peptides) or bacteriocins in conjunction with the general porin Omp, thus justifying its name of OmdA, for OmpD-Associated protein.	3.37629e-19
NZ_AP022570.1\|WP_163672434.1\|615508_616918_-\|FtsW/RodA/SpoVE-family-cell-cycle-protein	gnl\|CDD\|223843	COG0772, FtsW, Bacterial cell division membrane protein [Cell division and chromosome partitioning].	4.76507e-98
NZ_AP022570.1\|WP_163672447.1\|629308_630670_+\|cation:dicarboxylase-symporter-family-transporter	gnl\|CDD\|366058	pfam00375, SDF, Sodium:dicarboxylate symporter family.	3.78347e-128
NZ_AP022570.1\|WP_163672451.1\|632575_633373_-\|ABC-transporter-permease-subunit	gnl\|CDD\|132299	TIGR03255, PhnV, 2-aminoethylphosphonate ABC transport system, membrane component PhnV. This membrane component of an ABC transport system is found in Salmonella and Burkholderia lineages in the vicinity of enzymes for the breakdown of 2-aminoethylphosphonate.	2.82732e-51
NZ_AP022570.1\|WP_163672453.1\|634233_635403_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	1.40068e-125
NZ_AP022570.1\|WP_163672457.1\|636447_637131_-\|phosphonatase-like-hydrolase	gnl\|CDD\|274534	TIGR03351, PhnX-like, phosphonatase-like hydrolase. This clade of sequences are the closest homologs to the PhnX enzyme, phosphonoacetaldehyde (Pald) hydrolase (phosphonatase, TIGR01422). This phosphonatase-like enzyme and PhnX itself are members of the haloacid dehalogenase (HAD) superfamily (pfam00702) having a a number of distinctive features that set them apart from typical HAD enzymes. The typical HAD N-terminal motif DxDx(T/V) here is DxAGT and the usual conserved lysine prior to the C-terminal motif is instead an arginine. Also distinctive of phosphonatase, and particular to its bi-catalytic mechanism is a conserved lysine in the variable "cap" domain. This lysine forms a Schiff base with the aldehyde of phosphonoacetaldehyde, providing, through the resulting positive charge, a polarization of the C-P bond necesary for cleavage as well as a route to the initial product of cleavage, an ene-amine. The conservation of these elements in this phosphonatase-like enzyme suggests that the substrate is also, like Pald, a 2-oxo-ethylphosphonate. Despite this, the genomic context of members of this family are quite distinct from PhnX, which is almost invariably associated with the 2-aminoethylphosphonate transaminase PhnW (TIGR02326), the source of the substrate Pald. Members of this clade are never associated with PhnW, but rather associate with families of FAD-dependent oxidoreductases related to deaminating amino acid oxidases (pfam01266) as well as zinc-dependent dehydrogenases (pfam00107). Notably, family members from Arthrobacter aurescens TC1 and Nocardia farcinica IFM 10152 are adjacent to the PhnCDE ABC cassette phosphonates transporter (GenProp0236) typically found in association with the phosphonates C-P lyase system (GenProp0232). These observations suggest two possibilities. First, the substrate for this enzyme family is also Pald, the non-association with PhnW not withstanding. Alternatively, the substrate is something very closely related such as hydroxyphosphonoacetaldehyde (Hpald). Hpald could come from oxidative deamination of 1-hydroxy-2-aminoethylphosphonate (HAEP) by the associated oxidase. HAEP would not be a substrate for PhnW due to its high specificity for AEP. HAEP has been shown to be a constituent of the sphingophosphonolipid of Bacteriovorax stolpii, and presumably has other natural sources. If Hpald is the substrate, the product would be glycoaldehyde (hydroxyacetaldehyde), and the associated alcohol dehydrogenase may serve to convert this to glycol.	1.51064e-63
NZ_AP022570.1\|WP_163672455.1\|635404_636445_-\|2-aminoethylphosphonate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|237887	PRK15046, PRK15046, 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional.	1.43751e-162
NZ_AP022570.1\|WP_152514849.1\|628762_629134_-\|VOC-family-protein	gnl\|CDD\|380093	pfam18029, Glyoxalase_6, Glyoxalase-like domain. This entry comprises a diverse set of domains related to the Glyoxalase domain. The exact specificity of these proteins is uncertain.	2.37876e-25
NZ_AP022570.1\|WP_163679758.1\|626735_628214_-\|fused-MFS/spermidine-synthase	gnl\|CDD\|223498	COG0421, SpeE, Spermidine synthase [Amino acid transport and metabolism].	8.59971e-10
NZ_AP022570.1\|WP_163672442.1\|623757_625248_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|224983	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism].	1.56816e-130
NZ_AP022570.1\|WP_163672438.1\|621092_622373_+\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	5.80387e-52
NZ_AP022570.1\|WP_152514838.1\|618440_618908_-\|FHA-domain-containing-protein	gnl\|CDD\|224630	COG1716, COG1716, FOG: FHA domain [Signal transduction mechanisms].	4.52787e-27
NZ_AP022570.1\|WP_163672459.1\|637134_638250_-\|TIGR03364-family-FAD-dependent-oxidoreductase	gnl\|CDD\|132407	TIGR03364, putative_secreted_oxidoreductase, FAD dependent oxidoreductase TIGR03364. This clade of FAD dependent oxidoreductases (members of the pfam01266 family) is syntenically associated with a family of proposed phosphonatase-like enzymes (TIGR03351) and is also found (less frequently) in association with phosphonate transporter components. A likely role for this enzyme involves the oxidative deamination of an aminophosphonate differring slightly from 2-aminoethylphosphonate, possibly 1-hydroxy-2-aminoethylphosphonate (see the comments for TIGR03351). Many members of the larger FAD dependent oxidoreductase family act as amino acid oxidative deaminases.	8.2455e-117
NZ_AP022570.1\|WP_163672435.1\|616914_618444_-\|protein-phosphatase-2C-domain-containing-protein	gnl\|CDD\|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	1.26339e-81

>NZ_AP022570.1|WP_163679758.1|626735_628214_-|fused-MFS/spermidine-synthase
MGPRAAAALVFGSSAAVLVVEITALRLLAPYLGLTLETSTLVIGIALAAIALGSWAGGRAADRVDPRRLIAPAMGVSGVVVALSPAVVRMAAEWAPPLLILVASAAILVPGALLSAVTPMVTKIRLFDLADTGTVVGKLSGVGTVGAIAGTVITGFVLISRLPVSAILVGLGVLLVIGAAVVEWRAHGWVRSRAAVLVIALTVAALASAVAPGGCDAETKYHCAEVVADPDRDSGRTLVLDGLRHSYVDTADPTVLQYDYVRALAAVVDVAFPDRNALAAYHLGGGGLTFPRYLAEVRPGTRSLVSEIDGGVVGLDRDEFGDLAGTGIDIRVEDGRLGLQRLDTDTRDLVVGDAFGGVSVPWHLTTVEALSEIQRVLTPGGVYAANLIDHGELAFARAEVATVAEVFDHVALLGEPTDLVANPASARGGNLVVVASDRPLSVPALDDALTARDTGWTAIAGNELATWIGDAQVLTDDHAPVDQLLEPFGSGP
>NZ_AP022570.1|WP_163672445.1|625998_626490_-|STAS-domain-containing-protein
MRTVDVDNTLVYPPVPGDDRKQFSNATFAVRRCSRDRIAVGVRGDIDAVNGRELARYVVHHTRASRQLVLDLRSVDFFGTQGFTALYYISVHCARTDVDWAIVGSRHVRRLLSICDPGGELPLADNLRAALRRLDRISHSRHHRRWSARSEIRPHSNGHHRAS
>NZ_AP022570.1|WP_163672444.1|625294_625996_+|phosphodiesterase
MKASDLVGVPIEWGAALRDRRLFHPRGVLADGRIERVAPPDDGLPVPSGPVVGRLSKAVGVPGSLPDAAGLAWRMFAGPSGDSPWDVLLVTAGIGDASAVPNRLLLHPVTAWADTRYSSLMPLAYRGQLWWVRARLVTDIAADGLALDAVADTLAHGDIDFDIEQACGSGDFHPLARLRLSEIRPVTGPEQDVSFDPVRNTAPGVCVWPQWLRTFRRLAYRRSREGRDGRATP
>NZ_AP022570.1|WP_163672442.1|623757_625248_+|FAD-dependent-oxidoreductase
MDHPEHLDVLIVGAGISGIGAAYYLQQHHPDRQYAIVEARGATGGTWDLFRYPGIRSDSDLHTFGYEFKPWRDDHAIANADKILAYLRETAAENGIDDKVRFHHKVLGAEWSSEKGRWVVDIERTDTAELLQISANWLFCAGGYYRYDEGYTPHFEGRERFTGRIVHPQHWPEDLDYTGKKVVIIGSGATAVTLVPAMADKAEHVTMLQRSPTYVLPVSSKDRFANIAKTVLGDKRGYALARRKNIAKQRFVYQFCQQHPAAARRLIRRLNAKQLPAGYPVDEHFSPTYDPWDQRLCAVPDADLFAAIGNGSASVVTDRIATFTETGILLESGRELDADIIVTATGLTMQAFGGMVLTVDGAAVHLPDTVAYKGMMLSGVPNFAYAIGYTNSSWTLKVGLLCEHFCRLLAHMDAHGYDTACPVPDDPHMQTRPFIDFSAGYVQRAVDQLPRQGAGQPWVTSMSYHSDVRLLRDDAVADPNLKLTCSADVTAGLVAR
>NZ_AP022570.1|WP_163672440.1|622413_623625_-|helix-turn-helix-domain-containing-protein
MSWPRPSPAVRELIRQCAQIVVNARAEWLDELDASVLAASPTIAADPELAAAVSRSNRANLFFWGTANVRDPGAPVPPNTGPEPLTIAREVVRRGLDAYSLDAYRVGEAVAWRRLMDIAFELTSDPAELHELLEVCSRSISSFIDATLAGIAAQIDAERDELTRGTHAERRETVALLLDGAPIPRRRAEDRLGYALTGPHTAAVMWSDDSDAVARLDRTAEAIAQAAGVAHHLSVLASTATRWLWVPGVIPADGAAVLGAVHPPEGIRIAVGSTAAGPEGFRRSHFDALTTQQMMARLRSPQQLAFFADIELVALVTADTDRAASFVDRVLGDFATAEPDIQDSVRTFIAVQCNASRAAARLYTHRNTLLRRLARADELLPRPLADNVVDVAVALDVLRWQGR
>NZ_AP022570.1|WP_163672438.1|621092_622373_+|EAL-domain-containing-protein
MERVIQALVGSMEPASLMSRVAEQACVFAHKADGAAVTLLRATDNAYVTVSAHGVLATAVGFVVPKRGSLQGRAARERRPQLIEDAMVDSRLTARVRSMNQQWGTRSWAAIPLTYNHHAIGSLLLAAAEPGAFTEADVDSMLAISEFVSALIGAQSQIWTLLTQVMTDSEERGQRALTARFVASVMLPEAAEVGELQEELEALLAQSDGLSAVFQPMVHLASGEPIAYEGLTRFPTNASLTPQKWFITARRLGRGVAFEHAALREVLTAAERIPDRYPVAVNLSPSAVLDPSIQELLVSVDRPLIVEVTEHEPFPESLGPDLEKLRGAGIAVAVDDAGAGYASFVQLLRLRPDIIKIDGELIDGIDENPVKRAFATALKALGAELGAKIVAEAVETPAQLDTLTGLGIEYGQGFLLGRPVAEPFPP
>NZ_AP022570.1|WP_163672437.1|619098_620493_-|DUF3662-domain-containing-protein
MGLVDRFERKLEDKVGDAFARVFGGSIVPAEVETLLRREAESQAREVGRGRILAPNDYVITLSVPDYHKVSADPDITATTFAKHLEGYIHEQGWQTYGDVVVRFEQSPSLHTGQFRARGAVNPDTTNDVPAPPPRELSSPAEPGVPPMSDNPTYRGGQGPGQGRPADEYYDERYNRPEDQRGHYPPSEQGGYPPQGEPNYPPRGGYPDQGGYPEQGGYPDQGYPPPSYEQRPPAGYGPPPGYPDQGYRQAPGGYGPPPGYGPPSNDYDYGRPPGRPDDGGYPHQGRPGYPDQGGYPDHGGYPDQGGYPDQGGYGGQGYGGRQDYAQPDYGRYGEAPGGYPEQGYGDGGYGAPAGYGQGYGAGQGDYSAAGATVTLQLDDGSGRTYQLREGANVIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLSDLNSTNGTTVNNAPVQEWQLADGDVIRLGHSEIIVRVH
>NZ_AP022570.1|WP_152514838.1|618440_618908_-|FHA-domain-containing-protein
MQGLVLQLTRVGFLLLLWLFIWSVLRILRTDIYAPTGAVMVRRGLALRGSILPSRGGRNVPRQLVVIEGALKGTRIPLGTQPVLIGRADDSTLVLTDDYASTRHARLSPRGPEWYVEDLGSTNGTYLDRAKVTTAVRVPMGTPVRIGKTVIELRP
>NZ_AP022570.1|WP_163672435.1|616914_618444_-|protein-phosphatase-2C-domain-containing-protein
MTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEIASQLVIAALAHLDDDEPGGDLLSKLDAAVREGNSAIAAHIDADPELDGMGTTLTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDSFVQTLVDEGRITAEEAHSHPQRSLIMKALTGHEVEPALIMREARAGDRYMLCTDGLSDPVSQETILDALQIEDTAESADRLIELALRGGGPDNVTVVVADVVDYDYGQTQPILAGAVSGVDDQSAPPDTAAGRASAFNPKRTAAKRVVQQPEEPPPRPKSRRRMYIAAAVLVLVVLAGLAVAREIVRSNYYVGEHEGTVSILRGVQGSFLGLSLQEPYLLGCLNSRNELSLISADQSQQNLNCRLLGVSDMRPSERAQVTAGLPSGTLDDAIRQIEELSRSSVLPICAPPAPTTTSRAPATPRPAPAPTNGTRAPATTTPPTTTPPSPTRGPAPGPSPETPRTVTGAPAPSSPSPTVTALPPPPPEPGTNCREVP
>NZ_AP022570.1|WP_163672434.1|615508_616918_-|FtsW/RodA/SpoVE-family-cell-cycle-protein
MSTQPQSPVAVAPPLPNRRNAELFLLGFAAVITTVALLLVEANQEQGLHWDLAQYTVAYLALFAGAHLAVRRFAPYADPLLLPVVALLNGLGLVMIHRLDLAAEENRAQGFGGTANQQMLWTLVGVLGFSAVVILLRDHRMLSRYGYLCGLTGLILLAIPAVLPRSMSEQNGAKIWIQFPGFSIQPAEFSKILLLVFFASVLVSKRNLFTSAGKHVLGMDLPRPRDLAPLLAAWIASIGVMIFEKDLGTSLLLYASFLVMVYIATERFSWVVLGLGLFAVASVVAYYAFDHVRVRVQTWWDPFADPDGAGYQMVQSLFSFATGGIFGTGLGNGQPGTIPAASTDFIIAAVGEELGLVGLAAVLMLYTILIIRGLRTAIAVRDSFGKLLAAGLAATLAIQLFIVVGGVTNLIPLTGLTTPWLSYGGSSLVANYLLLAILVRISHAARRPIGSTSPGGPIAAASTEVIEKV
>NZ_AP022570.1|WP_152514849.1|628762_629134_-|VOC-family-protein
MIGKLHAVVMDSTDPRGLAEFWAEVLGGHVEADDETWVTLDDPTGRRLAFQLSPDHEPPAFPDPHGSQQFHLDVEVDDIDRAESDVLKLGATRVTDAPGEENFRVFRDPSGHPFCLVFDMTPD
>NZ_AP022570.1|WP_163672447.1|629308_630670_+|cation:dicarboxylase-symporter-family-transporter
MSASAVEPERRKLSLTAKVAIGMIAGLAVGVAFNVLGNQWISDNVVNGFLDMVGTAFLNALKLLVVPLVIFSLITGVTGIGDVRMLGRVGGKALGLYLMTTALAISVAIGIAQLIGPGRGFDMTGVDTSGIETEEAPSFWEVISGIIPTNPIEAFAEGEMLQIIFYSILVGVAALMLGERSEGFVRACGFMNELMMKIVSIVMAVAPYGVFALIARVFAEEGIDLFKPVMAYVVTLVGSLLFHLFVTLMVLYWALTRLNIRTFMRKIRAAQVFAFSTASSNATIPITLRAVTQRMGAGNSVASFTVPFGATINMDGTAIMQGVATVFLANVYGVDLGIAGYLTVIAMAVLASIGTAGVPGVGMVMLTMVLTQVGLPIEGVAIILGVDRLMDMIRTAVNITGDAAVTCIVAKSENKLDRDVYDDPDAGLRGDDDIEFDPEAEEDLAHTLEGARR
>NZ_AP022570.1|WP_152514851.1|630687_630954_+|YdeI/OmpD-associated-family-protein
MGSQPVPGGVVHELPADLRAALSGNDTALAAWQDITPLARNEFICWVEDAKQQKTRERRIRRTQEELEEGKRRPCCWPGCKHRERNGR
>NZ_AP022570.1|WP_163672449.1|631125_632574_+|amino-acid-carrier-protein
MEFIQEHLINPVSDLLYSYILVYLLVGVGLYFTIRTRFIQLRYFRRMIGQLFHSRTHCDGVSPFQAFCVGLASRVGTGNIAGVAIALTVGGPGAIFWMWVVAAIGMATALIEATLGQIFKVRADDGSFRGGPAYYIQRGLGSRAGGVVFAILLIFTFGIAFNMVQANAISDVVNGAYAIDVRWITAGLVILAAPVLFGGVRRVAQVAEIVLPLMAVVYALLALVIVALNISYLPEVLVQIVGGAFGLTELAGGFAGGIAAALLNGVKRGLFSNEAGMGSVPNVAATATVSHPVKQGLIQSLGVFVDTMIICTATAFIILVSGPSIYDPATPTRVEGATLTQAAIADSLGTWTVSLMTVLVFVFAFSSVLGNYVYAEINLFFLGAGRKTINVFRVFVLMAIGVGGVSKLTAVWALADVAMGLMALVNLVAIVLLGKWAFAAIKDFHQQSDAGADPVFIAEEADLPGHLFGDIWSRPAPVGSKT
>NZ_AP022570.1|WP_163672451.1|632575_633373_-|ABC-transporter-permease-subunit
MLLWSPRSRAVVLTVFALVVAVVFVLPLGTVVLAGLAGSWTGPLPSNLGLTRFGTALSGEDLASLSVSLQTAFLAGGIALIVGTWAALAAREAPDWLRRITDAVFHLPIAVPSVAIGLGLLIAFNSRPLLLGGTRWIVILAHTVLVLAFAFSAVSAALDRLDPAYRQAAESLGAGPVRVLTRITLPLLLPALGAAAGLAVALSMGELGATVMVYPATWKTLPVTIFGLTDRGQVFQAAAGTTLLLAVTLLALIVLGRIRGRAALR
>NZ_AP022570.1|WP_152514854.1|633382_634237_-|2-aminoethylphosphonate-ABC-transporter-permease-subunit
MTTVLDRDLTTPADPVPPRSTAWLWVLPPLALVLLVVLYPLLRVFWESSTGNSWGDVLGSQVFRDALWRTVAIAATSTAGCLVLGTFLAIVLAFVPFPGSALVGRLIDTVLALPSFLITLAFTFLYGSAGAVNAAISAITGSSSPLLDFLYTPAGVITAEITFFTPFVVRPLLAAFALIPRAQLDVAASLGASPLTVLRSVIMPEAWPALAAGGSLVLLLTLNEFGIVLFTGAKGVITLPVLIYTRGIVTFDLPGAAVIATVQVVLSLLLYGLYRVIFARLTAR
>NZ_AP022570.1|WP_163672453.1|634233_635403_-|ATP-binding-cassette-domain-containing-protein
MADTRVSQAGLRQRSAPVEPGSPAILFDRVGVSYGRGRKQTHALIDFNLRVAAGETVALLGPSGSGKSTALNALAGFVRPTSGRVRLAGRDVTELPPARRGIGVVLQSYALFPHMTVADNVAFGLRAQKTPRNEITSRVAEALDMVGMSGYLKRLPRELSGGQQQRVAIARALAIRPAVLLLDEPLAALDAALRQSMLAELQLLKEALPDTAMLYVTHDQAEALALADRIVVMNDARLMDVDTAENLWKRPPTSFTAAFLGGANLLPCTVGRVISGSALVTVGSRTVNADAPAPALGHDDWGPGSAALLCVRPHALQIVSTREKDAFTATVNAAVWRGAVTRLVLSVQSLPDVLVDVDVPGHTPFEVGSVVGLRLPEPAGVLVSTGNAP
>NZ_AP022570.1|WP_163672455.1|635404_636445_-|2-aminoethylphosphonate-ABC-transporter-substrate-binding-protein
MNLRTALATFSVAALATLTAACGGTGTSGSGDGTTLTVYSADGLATWYESTFRRFTDETGINVNLVEAGSGEVVSRVEKEQSNPQADLLVTLPPFIQKAAQLELLQPSGADTSGIESGQVGPDATFVPIVDNALSFIANPGANPPPVTWDDLLKPEFKGKLQYSTPGQAGDGTAVLVLLQHLRGKEGAMEYLKALQANNVGPSSSTGKLQPKVSNGELLVANGDVQMNLASIKDDGSTFTIFIPAEADGTRTSVSLPYVAGVTSGAPHAEEARQLLAFLISEETQKTVEPEALGMPVLESLKSNGAAEPNTPAAVLNGVDVWVPDWNAVLADLDADLAAYQQATGS
>NZ_AP022570.1|WP_163672457.1|636447_637131_-|phosphonatase-like-hydrolase
MQHNTIQLAVIDMAGTTVADDGLVVEAFDAAATAVGMPDAGPEREQARQYVLDTMGQSKIVVFRALFRDEGLAQRANAAFEDAYAALIADGRAVPIPGAAESLSRLRDGGIRVALTTGFSPDTQAKLIAALGWHDLADLVLAPGPGVRGRPYPDLILTALLRLGADSVHAVGALGDTANDIESALRAGCSVAAGTLTGAHDERQLVAAGATHVVSSVTDFADLLLKG
>NZ_AP022570.1|WP_163672459.1|637134_638250_-|TIGR03364-family-FAD-dependent-oxidoreductase
MRVTIIGGGILGTAHAWQAVRRGHEVTQLDREVEARGATVRNFGLVWVSGRSSGELDASLRSRTLWEELGAEVPGIGFRPCGSLTLLRTPAEVAVAEEVCTRADTGRRGFRLLEPGEARRINPALRGKFVAALHCSRDGAVESRQALPAIRAVLHGSGRYTFVPGAQARTVTGTRVVDDRGDSHDADVVVVCAGAAHGGLVAELAGPLPVRRVRLQMMQTAPLDEPLTTAIADGDSLRYYPAYAGNALEELRRSEHQDPIAAEHRMQLLCVQRRHGGLTIGDTHEYREPFPFDVAEAPYTYLTGVVEELLGRPLPPIRQRWAGVYSQCVDPGRLVYRAQVSDGVWVVTGPGGRGMTLGPVIGEHTADEIGL

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Crispr_ID: NZ_AP022570_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022570_3

673259-673366

Orphan

Consensus_repeat	Method
CGCCCGGCTCAGGCAGGTGCCTCCGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022570_3

>merge|NZ_AP022570|3|673259-673366|CRISPRCasFinder
CGCCCGGCTCAGGCAGGTGCCTCCGAGCCGAATCTTCCAAAGCGACAGTGTTCTTGCCGTACTGGAACAATGACGGCTGCCCGCCCGGCTCAGGCAGGTGCCTCCGAG

>NZ_AP022570|3|3|673259-673366|CRISPRCasFinder
CGCCCGGCTCAGGCAGGTGCCTCCGAG	CCGAATCTTCCAAAGCGACAGTGTTCTTGCCGTACTGGAACAATGACGGCTGCC
CGCCCGGCTCAGGCAGGTGCCTCCGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022570.1\|WP_163672517.1\|668111_668891_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237537
NZ_AP022570.1\|WP_152514891.1\|664473_664779_+\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|377587
NZ_AP022570.1\|WP_163672533.1\|680646_681993_-\|type-VII-secretion-associated-serine-protease-mycosin	unknown	unknown	gnl\|CDD\|274856
NZ_AP022570.1\|WP_152514908.1\|685509_686289_-\|DeoR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_AP022570.1\|WP_163672525.1\|673904_674768_-\|secretion-protein-EccK	unknown	unknown	unknown
NZ_AP022570.1\|WP_163672514.1\|665198_666578_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|223531
NZ_AP022570.1\|WP_163672527.1\|676065_677172_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227505
NZ_AP022570.1\|WP_152514905.1\|682189_682447_-\|HPr-family-phosphocarrier-protein	unknown	unknown	gnl\|CDD\|273389
NZ_AP022570.1\|WP_163672510.1\|660822_662604_+\|type-VII-secretion-protein-EccCb	unknown	unknown	gnl\|CDD\|274859
NZ_AP022570.1\|WP_163672530.1\|677640_679227_-\|ESX-1-secretion-associated-protein	unknown	unknown	gnl\|CDD\|376051
NZ_AP022570.1\|WP_163672521.1\|672080_673250_+\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NZ_AP022570.1\|WP_163672512.1\|663079_664387_+\|PPE-domain-containing-protein	unknown	unknown	gnl\|CDD\|366325
NZ_AP022570.1\|WP_163672519.1\|668941_671650_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368199
NZ_AP022570.1\|WP_163672535.1\|682510_684511_-\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|182066
NZ_AP022570.1\|WP_163672537.1\|684535_685513_-\|hexose-kinase	unknown	unknown	gnl\|CDD\|238570
NZ_AP022570.1\|WP_163672532.1\|679252_680650_-\|type-VII-secretion-protein-EccE	unknown	unknown	gnl\|CDD\|274857
NZ_AP022570.1\|WP_163672515.1\|666574_668101_+\|type-VII-secretion-integral-membrane-protein-EccD	unknown	unknown	gnl\|CDD\|274855
NZ_AP022570.1\|WP_163672529.1\|677305_677644_-\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|376829
NZ_AP022570.1\|WP_152514889.1\|662752_663049_+\|PE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376422
NZ_AP022570.1\|WP_152514892.1\|664817_665105_+\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|227179

Protein	Function_ID	Function_description	E-value
NZ_AP022570.1\|WP_163672517.1\|668111_668891_+\|hypothetical-protein	gnl\|CDD\|237537	PRK13875, PRK13875, conjugal transfer protein TrbL; Provisional.	0.000157835
NZ_AP022570.1\|WP_163672537.1\|684535_685513_-\|hexose-kinase	gnl\|CDD\|238570	cd01164, FruK_PfkB_like, 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose 6-phosphate pathway, which responsible for breakdown of the galactose moiety during lactose metabolism by bacteria such as L. lactis.	7.29815e-98
NZ_AP022570.1\|WP_163672533.1\|680646_681993_-\|type-VII-secretion-associated-serine-protease-mycosin	gnl\|CDD\|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	4.67636e-117
NZ_AP022570.1\|WP_152514908.1\|685509_686289_-\|DeoR-family-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	3.2314e-86
NZ_AP022570.1\|WP_152514891.1\|664473_664779_+\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|377587	pfam06013, WXG100, Proteins of 100 residues with WXG. ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.	4.9436e-05
NZ_AP022570.1\|WP_163672514.1\|665198_666578_+\|AAA-family-ATPase	gnl\|CDD\|223531	COG0455, flhG, Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility].	1.06531e-55
NZ_AP022570.1\|WP_163672527.1\|676065_677172_-\|hypothetical-protein	gnl\|CDD\|227505	COG5178, PRP8, U5 snRNP spliceosome subunit [RNA processing and modification].	1.38538e-05
NZ_AP022570.1\|WP_152514905.1\|682189_682447_-\|HPr-family-phosphocarrier-protein	gnl\|CDD\|273389	TIGR01003, Phosphocarrier_protein_HPr, Phosphotransferase System HPr (HPr) Family. The HPr family are bacterial proteins (or domains of proteins) which function in phosphoryl transfer system (PTS) systems. They include energy-coupling components which catalyze sugar uptake via a group translocation mechanism. The functions of most of these proteins are not known, but they presumably function in PTS-related regulatory capacities. All seed members are stand-alone HPr proteins, although the model also recognizes HPr domains of PTS fusion proteins. This family includes the related NPr protein. [Signal transduction, PTS].	2.16855e-19
NZ_AP022570.1\|WP_163672510.1\|660822_662604_+\|type-VII-secretion-protein-EccCb	gnl\|CDD\|274859	TIGR03925, T7SS_EccC_b, type VII secretion protein EccCb. This model represents the C-terminal domain or EccCb subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	0
NZ_AP022570.1\|WP_163672530.1\|677640_679227_-\|ESX-1-secretion-associated-protein	gnl\|CDD\|376051	pfam18625, EspB_PE, ESX-1 secreted protein B PE domain. The ESX-1 secretion system is an important virulence determinant in Mycobacterium tuberculosis. ESX-1 secreted protein B (EspB) contains putative PE (Pro-Glu) and PPE (Pro-Pro-Glu) domains, and a C-terminal domain, which is processed by MycP1 protease during secretion. This domain represents the PE domain located at the N-terminal region of EspB which carries the conserved YxxxD/E secretion motif.	2.13517e-12
NZ_AP022570.1\|WP_163672521.1\|672080_673250_+\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	1.42979e-37
NZ_AP022570.1\|WP_163672512.1\|663079_664387_+\|PPE-domain-containing-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.31487e-44
NZ_AP022570.1\|WP_163672519.1\|668941_671650_-\|hypothetical-protein	gnl\|CDD\|368199	pfam04931, DNA_pol_phi, DNA polymerase phi. This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.	4.07823e-09
NZ_AP022570.1\|WP_163672535.1\|682510_684511_-\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|182066	PRK09765, PRK09765, PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional.	1.21342e-140
NZ_AP022570.1\|WP_163672532.1\|679252_680650_-\|type-VII-secretion-protein-EccE	gnl\|CDD\|274857	TIGR03923, T7SS_EccE, type VII secretion protein EccE. This model represents the transmembrane protein EccB of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccE1, EccE2, etc. This model represents a conserved core region, and many members have 200 or more additional C-terminal residues. [Protein fate, Protein and peptide secretion and trafficking].	1.08317e-73
NZ_AP022570.1\|WP_163672515.1\|666574_668101_+\|type-VII-secretion-integral-membrane-protein-EccD	gnl\|CDD\|274855	TIGR03920, T7SS_EccD, type VII secretion integral membrane protein EccD. Members of this family are EccD, a component of actinobacterial type VII secretion systems (T7SS) with ten to eleven predicted transmembrane helix regions. [Protein fate, Protein and peptide secretion and trafficking].	2.11739e-91
NZ_AP022570.1\|WP_163672529.1\|677305_677644_-\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|376829	pfam02575, YbaB_DNA_bd, YbaB/EbfC DNA-binding family. This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure. The conformation of the DNA is changed when bound to these proteins. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage.	5.16778e-07
NZ_AP022570.1\|WP_152514889.1\|662752_663049_+\|PE-domain-containing-protein	gnl\|CDD\|376422	pfam00934, PE, PE family. This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	3.84075e-05
NZ_AP022570.1\|WP_152514892.1\|664817_665105_+\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|227179	COG4842, COG4842, Uncharacterized protein conserved in bacteria [Function unknown].	2.08716e-16

>NZ_AP022570.1|WP_163672521.1|672080_673250_+|Fic-family-protein
MDIDSLRDSPIGRLAPIKGHDPRIGKEYEYVAYVPNPLPETVELAADTYSVVIDAAAAMARADQSAALLPNPVLLARPATRREAVSTSALEGTYALLSDVFEADFLAAEDLTSSVSEVRNYVTAAESAYDMIADGQPISVRMLESLQGVLLRGTPSDGPQAGSVRTTQVFIGVGNRNVSSARFVPPPADHRLLDGLLQWQEWIREPSPVPTIVRVALAHYQFEALHPFHDGNGRLGRLVMVLQLMAAGDLRYPVLNIAPWLEQRRTEYQDGLLRVSQTGRWDDWVSFIAAAIHAEALEVIDRVEKLLALRESFRETLRGAKGVSRRIADDLIGYPMITVSLAASMYGVSYQAANTAIAKLVEKGILRQRTAGRYGRIFQSDSVLAVLEQ
>NZ_AP022570.1|WP_163672519.1|668941_671650_-|hypothetical-protein
MGSTGKHRLQTPHEGAHRRVQVRAHSQNIGRVGGLAAALGVGAVLFAAPWTAAADSDESSSSSSSASSSASSSSSSTPSGSSSDDSSSSGQRSSGADTDTDTDTDTDDDDDDFDAEADELDDADDELNADVDETDDAADDKDVEEDLAGELDDDIAEVDVADVAADAGGLDNDVGIDEAPAPQTPAPPSESPILPVAVSTESSRRSVLTPTAAATAQSAAAAPVDDTAEAPPAPTVAFQYAPGTFTQVATTLVSQQVAAMTEPAPASAQTSALVGVLSWIGQQIGVSFADFSVSINGTTIIQQGTAVAISDGFGSIAIARGSNTTATAEGWFSRAIVRGDDSTADATGGNFNTARVYGDNNDADATGGNFNTVRIVGHGNVGTATDGYSVVYLRSDVSSATTSGEGFSQAIIVGESNSATAFAQSRSRSKAVIIGSDSFANTVGNEGSTAIARIVGSAINSLSFAQGGADAVSFVSGAESSSVATAFGDGGLGRGATVVLIGEDNAGTASATDGRAAVVVRGTDSVGGAESTEGGAAYARVLGDGNTADADAFGGLSRALAVGTDSSAEASAVDGVASATAGSGSTAVADTDGGWAKAAAYDSSVASADSTDGSLANAFADDDSAASASADRGSASAVATDGSAAEATSQTGVASSSANNTSSATSSAFDDSWARSVARDTSSATAFGADGSYASSVAQVSSISNAVAIDDSRATVSARRSSDGLAYAQNDGRAMVTSDTNSSGNAAAENGARAYVTVSRSSTNVAEADGSGSVASATNIGANSVIASQADNGGHSRGFILGSDSAAQAGSDAGRADATVVGEMSAAVADSVNGSASAIALGDDNLADAEATDGAVVSDLATDGSGGAALQTAIFEVTALVTVLKAQIADKAMNAITQYINS
>NZ_AP022570.1|WP_163672517.1|668111_668891_+|hypothetical-protein
MGNPPPLSVDPEQLAAAGNELKYSAGQLPDPPGPFGVVGSDPLTQAIDLQIPAIEDPIATQLPAVKAQATKTAQNVISAAEAYLTTDQQLGGQISQEMQNLPAAEGLSGGAGSAGGAAASAAGGTAGAAGSAAGGSGPMSQMMGMPMQMASQMSQMPTQAMGAVTSAPQGVMQGAQQVGQQVQQMVGQFGEAGSSNVGSGPHAEPAAQEGAAAGDTRAERAPEVKDVPEAKDKVEGEDAAREESGGRHRRAEDDPGIDL
>NZ_AP022570.1|WP_163672515.1|666574_668101_+|type-VII-secretion-integral-membrane-protein-EccD
MTATATPASSPSVTPGQPSTTRVTILTGRRMTDLVLPSTAPIESYVDETVSVLAEILDDTPPDVLAGFDFNAQGVWSFARPGAPPMKLTESLDEAGVVDGSLLTVVSVSRTERYRPLVEDVIDAIAVLDETPEFDRRALYRFMGWMVPLVALVVTVVTMLSWSATGRDWWWAAALGAFGLGLAGASTLAQNRFNSLDMAESLLVAALFTLGGAVALAVPLPRGVDSIGAPQIAGAGALIFLMVLASRGGPRRRAEVAAFLAVMALAVTVAAVAFGYGWDSWVPAGAIAFGLIVVTNAAKLTVAVARIALPPIPAPGETVSNDELLDPVSTTDTSEESETWQAIIASVPDSAARLTERSRLAKRLLIGFLTAGAVILAAGSIAVVVQGHFFLHSLIVAGLVTVVCGFRSRLYAERWCAWALIAAAIAIPTGVMVRLCLWYPERAWLVLGIYVLVAVVAVIVVGATESVRRVSPVTKRILELFDGAAIAAVIPMLLWIAGVYDLLRNLRF
>NZ_AP022570.1|WP_163672514.1|665198_666578_+|AAA-family-ATPase
MSADYDRLFHSPDAVRTADEEIEHDTPPAGRDTASPHVAAPRSDATPPPMPIVQPRTQAAAAPPPRQSEITSQIPATQTTGPQHVPNNGMMRAPQTSAPQGARHEQQRPAPAPGPRHAPAPAPSQHFADPAADWRPAPQPAPTSAASMGNHRAIDALSHVGVRSAVKMPSQRGWRHWIYLMTRINLGLSPNEMYEMDLHARIRRNARDSYQIGVFGLKGGVGKTAVTVALGSALSKVRGDRILAIDADPDGGNLADRAGRQSAATISDLLSDKELHRYNDIRAYTSMNGSNLEVLSSEEYSAARREFNDEDWQGATDIVSRYYNLVLADCGAGLFQPAARSVLSTVSGLVIVASASIDGARQAAITMDWLRQNGYQDLLGRSCVVINHVVPGKPNIDVDDLVQQFERHVAPGRVIVLPFDKHIAAGTEIQLDLLGKTFERRIVELAAALSDDFDRLERR
>NZ_AP022570.1|WP_152514892.1|664817_665105_+|WXG100-family-type-VII-secretion-target
MGQINYEFGAIEAGAGEIHAAVGRTAGLLDEGQGSLARLQSAWVGDGSMSYQAVQQRWDANSNELNMALQSLAQAISNAGSTMGTTEAGVIGTFS
>NZ_AP022570.1|WP_152514891.1|664473_664779_+|WXG100-family-type-VII-secretion-target
MALVNADTPQLMAEAANFDRISGELQSVLAQVESTAAALQQSLHSEGAGQAAQAALLRFHEASNQQIRLLTDISQNIHTSGSSYLNTDANNADDLASQMQI
>NZ_AP022570.1|WP_163672512.1|663079_664387_+|PPE-domain-containing-protein
MAIPPIFIPPIWGAFPPEVNTSRLMAGAGPAPMLQAAAGWEVLAVSLETQADELAASLASLAQMWQGMGSERAITASMPMVVWLRMLALQAQKRALQASAQATSYTTALATTPPLPEIELNHVTHAVLEATNFLGVNTVPIGLNEADYVRMWDQAATVMSAYQAETTANATFEPVAPPQPIVLPGAASAAMSMGMASAAPMAGSAAVRNAAFTHVSGQGKIEEANLKAGRMEQAVNQAANQSRSQGDPGQMMQQAPQMGMQMASQLGSTLGQLPQQMMQGVTQPFQQLTQPLQQVSSMFGQMSGMMGGDRGAQIGMLGATPFSNHPAIGGNGAASGAGLVRAASLPGAGGTAARTPLMSNLVGKELQPTMSPVSVGAGAAAGAAAAGLAPVGGGGMGGGPMGMLGQRGKSGGSRSSLNAPAPLEHDLSEDDEDDW
>NZ_AP022570.1|WP_152514889.1|662752_663049_+|PE-domain-containing-protein
MQPLSHNAGAVGVGGQVVANGARGLATGTAATAQVSALTPAGADEVSVLASTAFMAEGVQTLGINALAQEEISRAGATVIEVAGVYQAVDGENGATLI
>NZ_AP022570.1|WP_163672510.1|660822_662604_+|type-VII-secretion-protein-EccCb
MTIESGQKVLREVVLDQLTTGENHAYRMWLPPLADPTPVNELIARDYDRRPLRIGLGVMDEPRRHRQEVWGIDISTAAGNIAVGGAPQTGKSTFLQTFILSASASHTPRQIQFYCVDMGGGGLMYIEDLPHVGGVATRAEPDRVNRVIAEVKAVLRQREQTFKQFRVGSMADYRQMREDPDNPASADPFGDVFLVIDGWPAFAAEFTELEAVVQDIAGQGLAYGVHTMISTPRWTELKARIRDYLGTKVEFRLGDVNETQIDRITREIPLNRPGRAVSTERFHLMIGVPRLDGVHSAEALVPAMAAAVQEVSARHTMEAPPVRVLPSRIHLHQLDANPPGPEADYRTRWTVPVGVRESDLTVAHSHMHTSPHHLIFGAPKSGKTTIAHALARAICARNSPEQVRFMVADYRSGLLEAVPETHLLAAGAINRNHATLEQSVKALAANLTKRLPPADLTPSQLRARSWWTGPDIVLLVDDWHMIVAAGGMMSPMAPLAPLLPAAADIGLHLIVTCQMSQAHRATMDKFVGAAYGAGTPTMFLSGEKQDFPSREILVKKRPPGQAFYVTPDGKEVIQAAYVDPPEEDVFAAPSDAG
>NZ_AP022570.1|WP_163672525.1|673904_674768_-|secretion-protein-EccK
MSAASASGAAAAPAPVPVSTARAERDAILAASTPGGRRRTGDSDPLQRARHIGAALNVGVMDFGFFWVTGVTADGTIVVANSYGLAYIPDGVHLPEHVKMATADESIAPAERATWATYPILAVQGWCRHHDKQLRAVVATEEQFANFDPGVAKIILTTEDIPDDGTMNGHSRLEVIAPDAAQRLTSIADTGLTELLPPAATDLEPPADQSAKLWFDVAKPLMSTSPQRGAAHLHAFVAYADHAQELALHRAQTASESDAQRHAITDWIYWQHLGVLMNDAVASEAPA
>NZ_AP022570.1|WP_163672527.1|676065_677172_-|hypothetical-protein
MTTPPPGPWPPPPPGPGQQPPSWGSQPPWGPPPQRGGNRAKWILGGIALVVVVGLTVVATLLVTRDGSGSGEPTASAPPSSSADTSDIASADDRGPVGVILEEPTCQSWTTISASIAHSASNGWDRRDPAIPAANWTPEQRRQYGAMSAAFREASDKAAALAKETPHREVRVLYEQFIAYSREYASRIPDYAADDDQFVRASNSLSATLNAICDSITFGAAAARSPLVTDGLPPSGNIAKPQPDDPSMFLASPNPQCAEWLNATKEFTDSTAAWRTVDPNIPAPELSPEQRAINDAAISVMDDFARYSILLGRASDNPVWADISALSAQYRLAYASALPSYSPADNDLQIVAASAAGAISAACRAAGV
>NZ_AP022570.1|WP_163672529.1|677305_677644_-|YbaB/EbfC-family-nucleoid-associated-protein
MIDDMHPEVAAVLRQAKRLQSLMDEQLDKMANETFTASDDTETVEVTLDGHHLLKGVYIQDGLLRLGAEVVEQRVNEALQKANEAASASIDADRERIDAVVAEITAEMPGES
>NZ_AP022570.1|WP_163672530.1|677640_679227_-|ESX-1-secretion-associated-protein
MSGEELQVDPRDLHGKAAQIDALAWPSQAAQPPLISADALVIASVAVTNLRVNADGLWARQAYGQKEGERLAQTLRNVGDAYAQIDQMSGEDIGATVGGPAPTGPGATVYPKPVDIPALPSPEAMPIPKGQLASDQGFMDVSAAEVALDAGDDGESLRAAAAMWRANGQSLATSAEAFEVNSLDWEGEAANAAYGKFNAYRDWLISLAESWKNLADEADRIASEHDKARDAHQPIAEEYKQLEEQTMGKPLTPQVMANLERMAELQASSEEIRTSYAAGATTRQFEPDDPPNPVVSGTPVTAEDHRRARRPAPDAADARQAGAGAGGGQPGGAGQAPPEGMPHEAPVSPMSAAEQAGQAASQGASQGGSPSGGQGGAPSGGAPGGVPSGMPGLGKGDPKLPTDPSLRPAAAGGGGGSGGGAGGGGMPSSPLQPAVGAETVAPTPVTAAGASTTAAGGTSGGGAMAGGGMGGMAPMMGGARGGESGDKKRNPQLSEDEEIYTEERPHTEPVIGHRPRRRGTDESKRESQ
>NZ_AP022570.1|WP_163672532.1|679252_680650_-|type-VII-secretion-protein-EccE
MNRVLALFGLRFTTGHALWAAVLIPACVLVFAAMDMLWLGITLAVIIGLAAVVTVRGRRLTGWVAALFAWRRRHRQPPATPSEPAVGATVIPGDHVALRWQGDHLVSAIELIPRPFTPTVIVNGEAFTDDVVHTRFVEELLSAYCPDLEADVVSSGYRVGKTAPAALVALYEQVVGPYPAPANRRTWIVLRADPERTRRSALRRDAGLSGLAQYLVASTTRIADHLASHGVDARPARSFDDYDRATEISFERETWSMIKGRSTFTAAYVAPGGPDVWWSARADHTLTRVRVAPGEAPTATVLLTTLANPSTPRGFSCLYGGQRAALLGESPVTDRHYELPVGSAGVLVGETADRYPVYMPFDDVDVSINLGDARLFTQFVVRSAAAGAVVTLAPQFREFAGYINARVGQVPKVVWPNATTYLGAHAGVGQVMLRQNYIATPRHKQLPIRLINPREESRYQMVLES
>NZ_AP022570.1|WP_163672533.1|680646_681993_-|type-VII-secretion-associated-serine-protease-mycosin
MRRIGALVAALAMVLLLAPPAGAIEPPVIDAGAVPPDETGPDQPMEQRRICAAPTVFPDSNFADQPWANDYLRLAEAQKFATGAGVTVAVIDTGVNGSPRVPAEPGGDFVDAGGTGMSDCDAHGTLTASVIAGRPAPTDAFVGVAPDARILSLRQTSDSFSPVGARTDPNNPNTTQTAGSLRSLARAIVHAANLGAQVINISEAACYKPTRRIDERVVGAAINFAVNVKGAVVVAAAGNTGGDCTQNPPPDPAVPADPRGWQQVQLIVSPAWYSPLVLTVGAIAPDGQPSGFSMHGPWVGAAAPGENLVALGYDGNPVNALQGEDGPIPISGTSFSAAYVSGLAALLRQRFPEYTPAQIINRITATARHPGGGVNNVVGAGVIDPVAALTWDVPAGPERIPYQVNEVPPPAYVPPPDRAPITWVVVVGGGVALALGVGALARRALRRR
>NZ_AP022570.1|WP_152514905.1|682189_682447_-|HPr-family-phosphocarrier-protein
MPSKNVVVGSAIGLHARPAAIIAEAVVNAGVPVTLSMDGGEPVDAGSALMIMTLGAGKGAEVTVESEDEGAMNTVADLVEKDLDA
>NZ_AP022570.1|WP_163672535.1|682510_684511_-|PTS-sugar-transporter-subunit-IIA
MTSSTTSPPIITRDLVLLDTDVEGDKQAAIAKLVGALADAGRTSDPDGLIGAAMAREEQSATGLPGGIAIPHCRSPYVDTPTIGFARLSPKVDFGAPDGPADLAFLIAAPESGGQDHMKLLTALARALVRKDFVESLRNAGSADEVVELVDGVVNPKPAADAAPAAADKPAEEKRAKHLVAITACPTGIAHTYMAADALAAAAKEAGVELTVETQGSSGSTPLPAETIANADAVIFATDVGVKDKGRFAGKPVVASGVKRAINEPAKMVAEAVAAADNPNAAKVEGSGADAGTAGAPAGKVGWGTRTRQILLTGVSYMIPFVAAGGLLIALGFLFGGYEIADTGNDIALNNSLTDLPPGGFLQYLGAVLFALGGLAFGFLVPALAGYISFAIADRPGIAPGFTAGALAVFIGGGFIGGIVGGVIAGFAALWISNLKVPQWFRGLMPVVIVPLFASLAVGLIMFFFVGRPLAWVNTSLTDWLNGLSGTSAIFLGIILGLMMCFDLGGPVNKAAYAFATAGLAASTTASFEIMAAVMSAGMVPPLAMALATVLRPKLFSEPERENGRAAWLLGASFISEGAIPFAAADPLRVIPSMMIGGAVTGGLSMAFGATSRAPHGGIFVLFAIENKIGFVIAILAGMAAAAASVIVAKQFIKPADKSESELVNA
>NZ_AP022570.1|WP_163672537.1|684535_685513_-|hexose-kinase
MIVTVTPNPSIDRTVTLPAQLTRGAVHRVTSVTNQAGGKGVNVARALTLAGVDTLAVLPAVANDPLTTALQAIAVPFQVVPTLEPARINLTITEPDGTTTKVNEPGATLDAATVTALTDAVLAAADAADWVVMSGSLPPGMPVSWYGDVVAQLAGHRCRIAVDTSDAPLAALCASLDRGAPDLIKPNGEELASVLGLPAESLEAAVAQGDPEPVVAAARQLIDRGIGAVLATLGAAGAVLVDRNGAWLATPPPITPRSTVGAGDSSLAGYVRAEVGGAVPPQRLQMAVAYGSAAAALPGTTLPTPAQVDLNAVQVAPISPIPATR
>NZ_AP022570.1|WP_152514908.1|685509_686289_-|DeoR-family-transcriptional-regulator
MYPEERQQAIASLVMAKGRASVTELAQAYEVTTETVRRDLAVLDKAGVVRRVHGGAVPVRALHLVEPGVGERDVTRAEYKDAIAAAAAEFFPLSGASVLLDAGTTTMRIAAQVPTDRSLVVVTNSVPIAARLATMPTVSLQLLGGRVRGVTQAAVGEQALRVLDTLRVDIAFLGTNGISVRHGLSTPDSDEAAVKRAMVRAANYVVVAADSSKVGREDFVSFAPISCVDTLITDPEISAEASRELTEQGVEVICAGGTP

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Crispr_ID: NZ_AP022570_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022570_4

1504175-1504284

Orphan

Consensus_repeat	Method
CGTTGAGGCTGCGTCCACGGCGGAGTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022570_4

>merge|NZ_AP022570|4|1504175-1504284|CRISPRCasFinder
CGTTGAGGCTGCGTCCACGGCGGAGTCTCCTCGCACTTTCCCGCAGTGGCTGCAGTCTCAACGCCAAGGTTTCGCGGTGGAATCGTTGAGGCTGCGTCCACGGCGGAGTC

>NZ_AP022570|4|4|1504175-1504284|CRISPRCasFinder
CGTTGAGGCTGCGTCCACGGCGGAGTC	TCCTCGCACTTTCCCGCAGTGGCTGCAGTCTCAACGCCAAGGTTTCGCGGTGGAAT
CGTTGAGGCTGCGTCCACGGCGGAGTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022570.1\|WP_152515595.1\|1512376_1512679_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022570.1\|WP_163673102.1\|1505099_1508465_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|227250
NZ_AP022570.1\|WP_163673095.1\|1497060_1497570_-\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|225113
NZ_AP022570.1\|WP_152515597.1\|1514890_1515832_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_AP022570.1\|WP_163673105.1\|1511514_1512120_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_AP022570.1\|WP_163673097.1\|1498166_1499060_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022570.1\|WP_163673106.1\|1512698_1514432_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|235624
NZ_AP022570.1\|WP_163673104.1\|1510889_1511471_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|188483
NZ_AP022570.1\|WP_163673103.1\|1509245_1510697_-\|DUF3375-family-protein	unknown	unknown	gnl\|CDD\|371764
NZ_AP022570.1\|WP_163673099.1\|1500652_1500943_-\|transposase	unknown	unknown	gnl\|CDD\|366690
NZ_AP022570.1\|WP_170311229.1\|1496697_1497051_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|378915
NZ_AP022570.1\|WP_163673101.1\|1501488_1503705_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022570.1\|WP_163673093.1\|1495828_1496587_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235500
NZ_AP022570.1\|WP_163673098.1\|1499186_1499354_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022570.1\|WP_163673107.1\|1515946_1518325_+\|esterase-like-activity-of-phytase-family-protein	unknown	unknown	gnl\|CDD\|379191
NZ_AP022570.1\|WP_152519502.1\|1508457_1509156_-\|DUF4194-domain-containing-protein	unknown	unknown	gnl\|CDD\|372745
NZ_AP022570.1\|WP_163673100.1\|1500985_1501369_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022570.1\|WP_163679914.1\|1504320_1504782_-\|TetR/AcrR-family-transcriptional-regulator-C-terminal-ligand-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|379883
NZ_AP022570.1\|WP_152515590.1\|1503860_1504130_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022570.1\|WP_163673096.1\|1497574_1498135_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228

Protein	Function_ID	Function_description	E-value
NZ_AP022570.1\|WP_163673102.1\|1505099_1508465_-\|AAA-family-ATPase	gnl\|CDD\|227250	COG4913, COG4913, Uncharacterized protein conserved in bacteria [Function unknown].	1.15913e-106
NZ_AP022570.1\|WP_163673095.1\|1497060_1497570_-\|GAF-domain-containing-protein	gnl\|CDD\|225113	COG2203, FhlA, FOG: GAF domain [Signal transduction mechanisms].	2.0986e-06
NZ_AP022570.1\|WP_152515597.1\|1514890_1515832_+\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	3.57997e-45
NZ_AP022570.1\|WP_163673106.1\|1512698_1514432_-\|AMP-binding-protein	gnl\|CDD\|235624	PRK05850, PRK05850, acyl-CoA synthetase; Validated.	0
NZ_AP022570.1\|WP_163673104.1\|1510889_1511471_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	7.44638e-13
NZ_AP022570.1\|WP_163673103.1\|1509245_1510697_-\|DUF3375-family-protein	gnl\|CDD\|371764	pfam11855, DUF3375, Protein of unknown function (DUF3375). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 479 to 499 amino acids in length.	9.14628e-108
NZ_AP022570.1\|WP_163673099.1\|1500652_1500943_-\|transposase	gnl\|CDD\|366690	pfam01527, HTH_Tnp_1, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.	1.85404e-10
NZ_AP022570.1\|WP_170311229.1\|1496697_1497051_+\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	0.00838769
NZ_AP022570.1\|WP_163673105.1\|1511514_1512120_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.44834e-07
NZ_AP022570.1\|WP_163673093.1\|1495828_1496587_-\|SDR-family-oxidoreductase	gnl\|CDD\|235500	PRK05557, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Validated.	2.59451e-87
NZ_AP022570.1\|WP_163673107.1\|1515946_1518325_+\|esterase-like-activity-of-phytase-family-protein	gnl\|CDD\|379191	pfam13449, Phytase-like, Esterase-like activity of phytase. This is a repeated domain that carries several highly conserved Glu and Asp residues indicating the likelihood that the domain incorporates the enzymic activity of the PLC-like phospho-diesterase part of the proteins.	7.78885e-43
NZ_AP022570.1\|WP_152519502.1\|1508457_1509156_-\|DUF4194-domain-containing-protein	gnl\|CDD\|372745	pfam13835, DUF4194, Domain of unknown function (DUF4194).	1.56385e-34
NZ_AP022570.1\|WP_163673096.1\|1497574_1498135_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	3.92218e-09
NZ_AP022570.1\|WP_163679914.1\|1504320_1504782_-\|TetR/AcrR-family-transcriptional-regulator-C-terminal-ligand-binding-domain-containing-protein	gnl\|CDD\|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	2.37715e-20

>NZ_AP022570.1|WP_152515590.1|1503860_1504130_-|hypothetical-protein
MSSSELSDVAWDLVEHCRAALSIPELNTAFVRLGVGDYSEAMVVALKSLTRSAGPPLTDQLLARLTSVEQTYHVEREFSELLAAAPRSG
>NZ_AP022570.1|WP_163673101.1|1501488_1503705_-|hypothetical-protein
MSVLDAFLSTWSNARATFGEGVPQPGTGYDQSASLTTLKSDLDQAAPGTHWSGGAATVYGNVNTEHQRVIGELGGLDRRLAAKVDQSAQIVAAGRQDLDAVRKWVLDAAASVPKNRAGEQMLVPIVSRGLGRLSDIVTRRNGELSTVGGDIRTIGSEYQALGTDQKFAADGDHGEDDGEDEGEDAPEETSAAEQGRQDSEALQDGTLTDEQRERLAESTTLTAQQQSTLDEGNLTMPPEQMSYLQGFSQAFGDKTPSEIKADMQAAGPDGARVADAFQLASNPTITTGLPGTEPPSVERPAAGGEHALPDGVRQVLDGPALTQPFSDTIRDDNGNVIVHGEPTGPLQPTKGLDDLADIVQSGNRDLQVGTDLDRGLMAKGQEMLEQSNRLPIEQAHGPGFGPLDDGPRWYHEHVDPTLQNMFNAVNADDVVVHDVVTGPGGGEFLDDLTKHQWQDDGLAAGGLFDWVAESAQDDPTGRAASTAHALAEYTSGHQPQLLNLAGTDGQSLGQVNPELTRDLSRVFAPYLDDMVGNNIDGTNDRFFPPLDGAEEQPLKTRALMSVMYSDSSENGAAATLFDGVGSKVEAYVHSAAASTADQDPTLAHADMKAAGRLQAALDLGSFDEAYDRLSNAQQAVHESYARRAMLFDTVAGLGSEVPGGAAVSPTLKELFLGPPPAVDAITPTATPQSSLPVQIMMAEELLNHELGNTEIREWLQQRLGEDGRLQVPDDDADPKIYN
>NZ_AP022570.1|WP_163673100.1|1500985_1501369_-|hypothetical-protein
MTRKTLACSIFVACIAALTQGCGSGGQPPTGQGSSAEEFANWPSALDNFRFHWTSDPEVPLTTGFAVPIRAYFESWYIASWTNNAEAVYPGFLRATSESDDLDGDYLGQLAWIRPLNGRPGYPTEPV
>NZ_AP022570.1|WP_163673099.1|1500652_1500943_-|transposase
MPEKRKKYDREFREGAVRIVEETGKPIAAVARDLGVHEGTLGNWVARAREAREGRGELTRDDLEELKRLRREVAELRMERDVLKRSVVLWVKEATK
>NZ_AP022570.1|WP_163673098.1|1499186_1499354_-|hypothetical-protein
MDADPPDFFVTPDMRRQCQEAMPDSPEKQIEMATGFKDTPPPHGKPIPGWPLAPQ
>NZ_AP022570.1|WP_163673097.1|1498166_1499060_-|hypothetical-protein
MIRRTSAFAIATLVAMTSAACGTEAGRDPATNPGLPAETDVANWPNSLAEFRFHWSSTAGIDVALGAAVPIRAYLESWYIASWTNDPENVYPGFLRATPESADLDGNYLGQLAWIRPLNGAPSYPVDPATPLGYMPMHIQSVDAVASGLRVTVCLGEYSIYFASDSSAGKLVSVAAEKSTAQLADPLDTVRVKRIELTKTDPRIPADASDVDTPQEGPAPAPVGDVFGHWFITGASSSLWGPVDADAPEFFVTPEMRRQCQEAMPDSPEKQIEMATGFKDTPPPHGKPIPGWPLAPQ
>NZ_AP022570.1|WP_163673096.1|1497574_1498135_-|TetR-family-transcriptional-regulator
MARPPKFDRDEALGCAMKVFWEKGFDGASISDLTAAMGISPPSLYAAFGDKQSLFDAAVDLYEQDAVLSPALKAATARDVAEQIFSRAVDLYTRPAHPRGCMVIADPTLQDRRRSGKDAIVRRLQRAKRTGDLPADSDPRALADYLDLVLRGMSSKARDGATRAQLRAAADVALAAWPAPTRNLAD
>NZ_AP022570.1|WP_163673095.1|1497060_1497570_-|GAF-domain-containing-protein
MTEHDDTTASHRPDATDGLASVAPGLEELAQQLNVKSVLVMRSEPDSMVVAATGGEATQHYTVGAAGKKAGNDQDRTPLYCERVVNSDEALFVRDSRTDATFAGNEDETEFGLHNYLGLPVHDAEGNVVGTVCALDDTARDYSAEEQQKLAQLRSDVEALVKENPDALR
>NZ_AP022570.1|WP_170311229.1|1496697_1497051_+|nuclear-transport-factor-2-family-protein
MEENLLAVFNERDPQRRLEVIRRNYAPDIRWADGEGTVTGQDRLHEKAQELLDGQLAGLGFSQSGPVYQAGNMGFLAWDVFPPGNESGTPLVSGFDVALVENGVIAQLFTVVTSAPG
>NZ_AP022570.1|WP_163673093.1|1495828_1496587_-|SDR-family-oxidoreductase
MTHSPTLPLSGRRALVTGGSRGIGAGIVRRLVADGADVAFTYSTSAGAADNLVAELSTNGVKVVALQADSADAGAVQAAVGETVHQLGGVDILVNNAGIASLAPLESLSLEEFDRMVAVNVRAVFVAIQAAVKHMTDGGRVITIGSVNGDSVPVAAGLSVYAMTKAAVAGLTRGLARELGPRQITINNLAVGPVATDLNPDEGDFADANRAQTALGRYGDTADVASVVSYLSRPEAGWVTGATWAVDGGYTV
>NZ_AP022570.1|WP_163679914.1|1504320_1504782_-|TetR/AcrR-family-transcriptional-regulator-C-terminal-ligand-binding-domain-containing-protein
MAHRHGLDAEEIQRHWPDPESLVLDALASRPGDDSPLPDTGSLREDLFQLAVRMAEMVTSEAGRKLHGGHLIADQFLASLEVRQTAWRHRAARLAVVFDRARQRGEIRAGVEHTTALELLFAPINMRALYTGEPVDHAYCRTVADLVFNAVAS
>NZ_AP022570.1|WP_163673102.1|1505099_1508465_-|AAA-family-ATPase
MTEQFHLSRLQVINWGVFDGYHSIPFSSGGALIAGASGSGKSSLLDAISLGFLPFNRRNFNASGDNTAAGSSAGRRTVDKYVRGAWGQRSDGGTSRVMYLRGDGTAWSAVAVTYTGDTGRSVTGLVLKWLTGESRNDSSSRFVLGDGDLDIEDICNRWAAGRFDTGVFKEGDWRFTTKVESQYLAQLYATIGIRASDAAQQLLGKAKSLKSVGGLEQFVREFMLDEPDSLARLPEALKQIDPLVEARELLAVAQRKRKILGDIEAIQHRYASESSDLGIIDLVDAPMVRAFTDHVRVAQCPAQITELDTAIDQLDNEDEDVMRALNLAKAEADSINAQISGSSASIGPLQSQVAAAETEAEQVSRRRSAYEDLVLAQGLEVPGSAEEFWNLREELLTKAAELLARVERNREASTDAEYAQKAARIARDDAAKELRRVEQVGSALPEFALTMRDQVCAALGVDASALPYVAELMDLRADQTRWRVAVEKVLRGVGLRLLVPDEHWAAVLRFVNETNMRGRLALHHVRAKSLGAEPAPLEPNTLAGKLFVVDPAHPCAAEAADVVAAAGDHLCVDTPDVFARFRRAVTDTGLYKDSDRLAVKDDRRPLKQSDYLYQGDVSAKINALTVDLAAAEDAYQSARRSADDIAAQRQQWRDRATAAKAICDQYPQWSQIDSETADGHADRLREQYELLLAEHPDIEALNARADECWEQIQKLMTRRGAIQTRREDLDTRRTRLLELSERLSPAFVSEPLTDLLRRYTAMVPVPLEVLEPEPHREALFAAIKREREQLRESRRRSYDELARILNTFDTTFPDAIPNDSSNFDERVHDYVALCRHIDERELPEAYERMMRLVTEQAPDAILTLHRVAEQEARRISDQIDRVNTGLGAVEFNRGTRLTLRATPRALAAVSELTEIVRAISRRIAEVGLGDKQAILDQYADILRLRNRLASTAPEDRAWTRDALDVRNRFTFDCAEWDIASEELIRTHSNAGDNSGGEQEKLMAFCLAGALSFNLAAPDSSDNTPVFAQLMLDEAFSKSDPQFAQQALQAFRKFGFQLVIVATVQNATTIQPYIDSVVMVSKTEATGRNARPVATVATRSIAEFGELRREMSVTAARVPAGV
>NZ_AP022570.1|WP_152519502.1|1508457_1509156_-|DUF4194-domain-containing-protein
MDTESIDYRGFSDLPQVDQNARPPAQRRPRFDGDVSELPDRACWALQHLLTRRYVSAENDADIYAWVLEYRNQLSVRLSELDLLLRVVDGTDVAFVEQARYESAKGIKLLRREPLGTYDSILALHLAQMMRAAGGQRVLISREEMHGLFSGVLNDTDRDAVTFTARIDAAIARLTGLEILRRSRDDEDSYTISPVISAIMTASVITELQQQFELLARGGAPADDTGEVELDD
>NZ_AP022570.1|WP_163673103.1|1509245_1510697_-|DUF3375-family-protein
MHDTAQPSVAELLDHNRDLQGSRAIRLLATHNLGLYATLMERHLADGVIPETELVIRLERDLDDVGHPDGQSGLALIKSWASQGWLHRIVDERSDQNVCYLTQDARRALDFVRGMRRNDTIATGGSIHGIASRLKQVAVRVDNDPARIRKHIEAEIAALHSELDQLDAGERPDPDPTDCYDEARAIALQMERLITDIGQYGTMIEQATAALDEPIDTNTEYRDRQRQMYADYQAAWDSQGRDSHRAFLRMINDPDQRAEFEADVAAVADALPALDPALRKVMAGFFELVGHQIDEVERIQQRCAQRVKRFTAFGTLEQSRGVARQLNEALGSARALLKTSLTDSRLDLDVPLARHAISSVGALSFKIGDLSAPKPARPADGQVDLASFAALTTQVDAPAMSQMLNTALHRGPVSLPDAVALLESAYLGHVIVLWSWALKQPAAESVRESTTVRFRSLDGRDREIAVPKLMFTEPITALVGAST
>NZ_AP022570.1|WP_163673104.1|1510889_1511471_-|TetR-family-transcriptional-regulator
MSVSHSESKGLRERKKMQTRLAIRREAFRLFTEQGYAETTIEQIAAAAEVSPRTLYRYFGVKEALLLSDDHISPTVEAFANAPRHLSYVQAYHHAVNEVYGALSPEEREDAIAGQQILYQVPEARGLLYTAYLTLADLLTEALLRRPDGPADEAERRVMAGAIMGVLILTAQDTPLPEAAMDRALSILDSRLS
>NZ_AP022570.1|WP_163673105.1|1511514_1512120_-|TetR-family-transcriptional-regulator
MDERLSSGRHHLSPDEVAADQQKRLFKALAVVMGEKGYSNTTVGDLIKHARVSRATFYQQFESKQDCFMAGYARMQSNVLGGLRATPVLGSPMARFRAMLTNYLNFLAADPPTARLYLVEVYAAGPEALRRRMQLQQDFVAGVAEVFAARSKADRFACQALVAAISMLVTGALADGDAQAILALEKPLVEFTERALPASLH
>NZ_AP022570.1|WP_152515595.1|1512376_1512679_-|hypothetical-protein
MGDLQSIGHGGQPTPVVFRAVDPPQDVLVDLVALFPREPHSHGRYHPFGLQMHKVVRGELTRWGMCEQGHWWGLVSYPVSHGPKSDLVMHWIPAWMLKKA
>NZ_AP022570.1|WP_163673106.1|1512698_1514432_-|AMP-binding-protein
MPPIATSIPAALAARAQAQPDDVAYTFIDYEYDPAGAAESLTWSEVHERVQIVAEKLSKLGAPGDRAVILAPQSLDYVVAFLGAIQAGFVAVPLSMPMFRQHDERVSGVMADATPVAVLTTSDVIEDVRKYGQVESRSHAPKFIEVDTLDFDSPAKPPAPVALPKAGYIQYTSGSTRRPAGVVVTHQNIFENMEQILPDFFEAYDEPPADLTVVTWLPLYHDMGLLVGVFLGMRMGRSTVLMTPVAFMQKPARWIQQLALNPHTFTAAPNFAYELAVKRTKDEDLAGLDLSGVVVMINGAERVHGATVRRFNDRFGPYGLPEAAMRPSYGLAEATVYVTSSAGGRAPTSVRFDYDELAAGRAQPCAEGAGSEHIGLGVPRSTTVRVVDPQTRVEAPAGTIGEVWLHGPHVAGGYWHNPQLTEELFAGQLAQTSEGTPKGPWLRTGDLGVLFDEELFIVGRIKDLLIVDGRNHYPDDIEATVQELTGGRVAAVSVPDDPSEKLVVIAELKKQLDAEVLDSVKQQVTAAVSQTHSVRLDDLMMVGPGSLPLTTSGKVRRGTCVELYHSDGFRRLDAAPA
>NZ_AP022570.1|WP_152515597.1|1514890_1515832_+|diguanylate-cyclase
MTKVPVGEAMQRRLLVALLAILLVLYSAAVVQAPLLADTRGEWIGAGLCVVGLGAAIGAGTHGARYLVAVSCLCAAPVVTMLFHRLIVAQVWSLIPLMFAAVYVRTWHRPAVARIVAVTLSAAAVAALWLAPAPAPWLWSVSFPVCILGAAEVVGVLHAALFDAALRDPLTGVWNRAGVDRRAGELVDRARRRNESVAVLVLDVDDFKAVNDRDGHAAGDIVLTQLARRLVAQLPEQAVIGRLGGDEFVVVLSGVDEGSARQIAGDLRGTGPVHVTAGVAVGRPVDGDGFTELLVTADDDLYRAKRHRNPGLR
>NZ_AP022570.1|WP_163673107.1|1515946_1518325_+|esterase-like-activity-of-phytase-family-protein
MAGTNRGTARRAATAVAITAVVVAGCSTDNQDDAGDTAAPDTPRATSPIDFDLPAAQRYHRTATYPVYLNKPEGDSVDAETVAEISTVTPDGNTVIYTDAAAKRIGFVDVADPVNPVGQGTLSLEELGNADDQPTSVAAVADVVLVVIDTTGGDFANPSGRVDIVRVSDRTPVHSIDLGGQPDSIAISPDGSFAAIAMENQRDEEATPPGGEEGDLPQPPTGFLQLIDLAGEPNTWSARRVDFDVEAARSAGLDTPEDLEPEYVSINSRGQVALTFQENNGVAIIEGRTGEVTNIFSAGSESVEGIDTAEDGTIDQSGSISDTPREPDAIGWVGDDHVVTANEGDWKGGTRGWTIFDATTGEVVWDAGNSFSQLAVRTGLHIEGRAESKGPEPEGLAITEINGTPTALVASERSNFVAVYDVSDVTAPQFRQILPTTPGPEGVLPIPSRNLLVISSEADDAEAGVRASLNVYGFGDRFAASGGGDQSAASGGTPMFPSIVSGDVDGAPIGWGALGALSADPADENRLYTATDNAYGPARVLGIDLTQTPALIDTELPVTDNGEAVTLDVEGISARPDGGFVLGVEGEEGPGNELVIVAADGSVEKRVTLPADIADAMGGQGIEGVAVDGDAIWVALQRELETDPPGVARLGRYTPDSDSWEWFGYQLDTTDTEGDWIGLSEIAVYDGSLLVLERDKLNGPDARVKAIYRVALPEDAGVTSATEAPQVLPKTLARNLVPDLQATKGFVQEKVEGFAVAGNGNLYVVTDNDGLDDANGETQFLDLGPAATALGG

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Crispr_ID: NZ_AP022570_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022570_5

1638003-1638096

Orphan

Consensus_repeat	Method
CGCGAAGGCGACGGGTCAGTGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022570_5

>merge|NZ_AP022570|5|1638003-1638096|CRISPRCasFinder
CGCGAAGGCGACGGGTCAGTGAGAATCGAGGGACGAGGCTCGGAGCTGACCCGGAGTCGAGCAATGGACTCCGCGAAGGCGACGGGTCAGTAAG

>NZ_AP022570|5|5|1638003-1638096|CRISPRCasFinder
CGCGAAGGCGACGGGTCAGTGAG	AATCGAGGGACGAGGCTCGGAGCTGACCCGGAGTCGAGCAATGGACTC
CGCGAAGGCGACGGGTCAGTAAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022570.1\|WP_163673161.1\|1625998_1627567_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|177094
NZ_AP022570.1\|WP_163673162.1\|1627596_1627857_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022570.1\|WP_163679936.1\|1632768_1633548_+\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|128941
NZ_AP022570.1\|WP_163673164.1\|1628202_1628727_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022570.1\|WP_163673163.1\|1627853_1628201_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022570.1\|WP_163673169.1\|1642396_1643602_-\|ornithine--oxo-acid-transaminase	unknown	unknown	gnl\|CDD\|179736
NZ_AP022570.1\|WP_163673165.1\|1631076_1631766_-\|serine-hydrolase	unknown	unknown	unknown
NZ_AP022570.1\|WP_163673167.1\|1633574_1633904_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022570.1\|WP_011558402.1\|1635367_1635838_+\|30S-ribosomal-protein-S7	unknown	unknown	gnl\|CDD\|235398
NZ_AP022570.1\|WP_163673174.1\|1647847_1648366_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NZ_AP022570.1\|WP_152515674.1\|1634993_1635368_+\|30S-ribosomal-protein-S12	unknown	unknown	gnl\|CDD\|235355
NZ_AP022570.1\|WP_163673170.1\|1643616_1644507_-\|N-dimethylarginine-dimethylaminohydrolase	unknown	unknown	gnl\|CDD\|224747
NZ_AP022570.1\|WP_152515676.1\|1638201_1639392_+\|elongation-factor-Tu	unknown	unknown	gnl\|CDD\|234596
NZ_AP022570.1\|WP_163673168.1\|1640568_1641387_+\|SHOCT-domain-containing-protein	unknown	unknown	gnl\|CDD\|378276
NZ_AP022570.1\|WP_163673172.1\|1645134_1646328_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|369639
NZ_AP022570.1\|WP_163679939.1\|1639681_1640515_+\|cutinase-family-protein	unknown	unknown	gnl\|CDD\|366455
NZ_AP022570.1\|WP_163673175.1\|1648568_1649147_-\|mycofactocin-system-transcriptional-regulator	unknown	unknown	gnl\|CDD\|188483
NZ_AP022570.1\|WP_163673166.1\|1631959_1632484_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022570.1\|WP_163673173.1\|1646459_1647851_-\|glyoxalase	unknown	unknown	gnl\|CDD\|319910
NZ_AP022570.1\|WP_163673171.1\|1644619_1645066_+\|Lrp/AsnC-ligand-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|214628

Protein	Function_ID	Function_description	E-value
NZ_AP022570.1\|WP_163673161.1\|1625998_1627567_+\|AAA-family-ATPase	gnl\|CDD\|177094	CHL00195, ycf46, Ycf46; Provisional.	1.75127e-82
NZ_AP022570.1\|WP_163673169.1\|1642396_1643602_-\|ornithine--oxo-acid-transaminase	gnl\|CDD\|179736	PRK04073, rocD, ornithine--oxo-acid transaminase; Provisional.	0
NZ_AP022570.1\|WP_163679936.1\|1632768_1633548_+\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|128941	smart00701, PGRP, Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine.	3.01225e-15
NZ_AP022570.1\|WP_163673172.1\|1645134_1646328_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|369639	pfam07992, Pyr_redox_2, Pyridine nucleotide-disulphide oxidoreductase. This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.	1.65978e-60
NZ_AP022570.1\|WP_163673171.1\|1644619_1645066_+\|Lrp/AsnC-ligand-binding-domain-containing-protein	gnl\|CDD\|214628	smart00344, HTH_ASNC, helix_turn_helix ASNC type. AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli).	5.88808e-33
NZ_AP022570.1\|WP_163673170.1\|1643616_1644507_-\|N-dimethylarginine-dimethylaminohydrolase	gnl\|CDD\|224747	COG1834, COG1834, N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism].	1.07893e-78
NZ_AP022570.1\|WP_011558402.1\|1635367_1635838_+\|30S-ribosomal-protein-S7	gnl\|CDD\|235398	PRK05302, PRK05302, 30S ribosomal protein S7; Validated.	3.3407e-107
NZ_AP022570.1\|WP_163673174.1\|1647847_1648366_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	3.55023e-27
NZ_AP022570.1\|WP_152515674.1\|1634993_1635368_+\|30S-ribosomal-protein-S12	gnl\|CDD\|235355	PRK05163, rpsL, 30S ribosomal protein S12; Validated.	1.84656e-83
NZ_AP022570.1\|WP_152515676.1\|1638201_1639392_+\|elongation-factor-Tu	gnl\|CDD\|234596	PRK00049, PRK00049, elongation factor Tu; Reviewed.	0
NZ_AP022570.1\|WP_163673168.1\|1640568_1641387_+\|SHOCT-domain-containing-protein	gnl\|CDD\|378276	pfam09851, SHOCT, Short C-terminal domain.	0.00093272
NZ_AP022570.1\|WP_163673175.1\|1648568_1649147_-\|mycofactocin-system-transcriptional-regulator	gnl\|CDD\|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	4.79924e-92
NZ_AP022570.1\|WP_163679939.1\|1639681_1640515_+\|cutinase-family-protein	gnl\|CDD\|366455	pfam01083, Cutinase, Cutinase.	7.95064e-10
NZ_AP022570.1\|WP_163673173.1\|1646459_1647851_-\|glyoxalase	gnl\|CDD\|319910	cd07246, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	5.22003e-26

>NZ_AP022570.1|WP_011558402.1|1635367_1635838_+|30S-ribosomal-protein-S7
MPRKGPAPKRPLVNDPVYGSQLVTQLVNKVLLDGKKSLAERIVYGALEQARDKTGTDPVVTLKRALDNVKPALEVRSRRVGGATYQVPVEVRPDRSVTLALRWLVSFSKARREKTMVERLANEILDASNGLGAAVKRREDTHKMAEANRAFAHYRW
>NZ_AP022570.1|WP_152515674.1|1634993_1635368_+|30S-ribosomal-protein-S12
MPTINQLVRKGRHDKVAKVKTAALKGSPQRRGVCTRVYTTTPKKPNSALRKVARVRLTSAVEVTAYIPGEGHNLQEHSMVLVRGGRVKDLPGVRYKIIRGSLDTQGVKNRKQARSRYGAKKEKS
>NZ_AP022570.1|WP_163673167.1|1633574_1633904_-|hypothetical-protein
MALSVSVPISQPECDGSGIVVLRSAVTPGNYGTEIQRYLNEFPGASYLRTDHSCPSLRQSTASGDPIYAVYRPAGRTEAEICSEVRRAGGDAYGKWLDMTTDPGFMITC
>NZ_AP022570.1|WP_163679936.1|1632768_1633548_+|N-acetylmuramoyl-L-alanine-amidase
MNRRQLLWVAGGAGIAAAASVYAKQLDAGVPVAEGTTSRAASVKPAPPAPAPEPVVTPAPIAASAAVICRDAWGARESLPGGVRHTITRMTLHHTAAVLGDNRNAPGRLRQHQRLHQDERGWVDIAYHVGIDRNGNIYELRNTDFAGDTATEYNPAGHFLVLCEGDFDQEAVSEEQLHSAAMAFAWAAQTFEVSADSLGSHRDFAATACPGADLYAHVESGDLRRRIDALLAAGTVDLHRVCGPEASEIVAAVEAGAPA
>NZ_AP022570.1|WP_163673166.1|1631959_1632484_-|hypothetical-protein
MTAAVTLLLSGSDSDSAPTARYDIADPRYSDNENAGSDERSDHRTTDRPNPRRQSAVDRFSAAPPPPIVREPDTFDEVCASGFQIAGRSGWGTRSGRGSDQTSCFFARSVLHAYWDQHGSPDETGRTVIAEGTVPCGTTGGECSGDRFVMRCAVLGQDTWITCTGGKNARVLIY
>NZ_AP022570.1|WP_163673165.1|1631076_1631766_-|serine-hydrolase
MAEQIAGEVSVSVMSGSDVHTFGDAVTGPAWSTIKVPVAIAALRAAPVQAVDYLSAAITRSDNAAAESLWSLLGTPTDAALAVTSVLHDAGDAETVIQSERIRAGFTAFGQTDWPTPQQAAFAWQLPCISGSGEVIAEMQQISPDQQWGFAGDHGVAAKGGWGPAPDGSYLVRQLALLRGEAGSIGVAMAVTPGDGTFQSGVGALNQLADWVDEHRQDFSWSDCTAGTQ
>NZ_AP022570.1|WP_163673164.1|1628202_1628727_+|hypothetical-protein
MASDIERVAKALNALASDTGRTGQGVTHAVQEAARLLDRAQALRNSGVSVARLVGQLQAALDKGRSAAAGVEQIERTGHSFADRLADRAGGGQGTAGFLADVSIGFATALSFLGSPQSMLSDSPDTTGAGEVGGSSMIDRSLSAQSDLDDLHRFNRDRSDKMIRPEGHDPNRDS
>NZ_AP022570.1|WP_163673163.1|1627853_1628201_+|hypothetical-protein
MTRSGEHDDPVALERAAREFHAIARSARAQAGYLDKHAGKVEPVAQGVSSIIGGTASGTDKRMIGTLTRALRDLQDASRRLNESAHAAEQLAREATARALSAREAQAAAQSARRR
>NZ_AP022570.1|WP_163673162.1|1627596_1627857_+|hypothetical-protein
MSELQKLKGTLETIASSAKQTGGSLGQFKSKFSAHQGQVRAAIGGSSQRKDQEVLQALDAASKQVTAAVQALEQAARVAANYGRSL
>NZ_AP022570.1|WP_163673161.1|1625998_1627567_+|AAA-family-ATPase
MPNQADTADELRRYLNARIPLIVLRTSEARRAQELIRQVAGQLKAMSFYCHTRTGGLAELLSQKAIVDDRSLLGAFDYAAATFRSRDYVNFVFVDVEDIGDDSSTSRHLAELADLAENRSGSIILITAGSVSTGLMRLGMAVELDLPDLDELFYVVSDLIDNYRGSMQIDWNHDDVRQASEVLVGLSESQALNAISTLLAKGKLIQDDIVELSTFKDRMFGAISGIERVPLRPEDSQVGGLTQLQSWLRERGEMIRMDLTHSRLRPPRGVLLVGVPGCGKSLSAKVVAAEWRFPLYRLDMSSVLGMYVGQSEGRLREALDMASRVAPCVLWIDEIEKALAGGVAGGDSSGTTRRMIGHFLYWLQESRAKVFVVATANDVSSLPPELLRKGRFDELFFVDLPDPEDRAEIIRLYYQSYLETDVSPYLLEELVTLSDGFAGADIAAVIHELASYKLRQRLGSAPISDEMVKDGFRNLMPFSRTNPEDVAAIRAWGLERAVPAGRPRQVDDGDAGRGVRRIMTPN
>NZ_AP022570.1|WP_152515676.1|1638201_1639392_+|elongation-factor-Tu
MAKAKFERTKPHVNIGTIGHVDHGKTTLTAAITKVLHDKFPELNESRAFDQIDNAPEERQRGITINISHVEYQTDKRHYAHVDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVGVPYILVALNKSDAVDDEELIELVEMEVRELLAAQDFDEDAPVVRVSALKALEGDEKWVKSVEELMEAVDASIPDPVRETDKPFLMPVEDVFTITGRGTVVTGRVERGVVNVNEEVEIVGIRPGTTKTTVTGVEMFRKLLDQGQAGDNVGLLLRGIKREDVERGQVVTKPGTTTPHTDFEGQVYILSKDEGGRHTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDNTDISVKLIQPVAMDEGLRFAIREGGRTVGAGRVTKIIK
>NZ_AP022570.1|WP_163679939.1|1639681_1640515_+|cutinase-family-protein
MAAVAAAAITSGAAAVGLTTGVASAQPQCPDVHWIGAAGSGERAGDLTADGGMGRVVHKSYRDFAQLVAQDGRTVTGEAVQYPATAVPEDGGILDWANFMSSVDTGAEALGQQYATFVAQCPTSQVVLAGYSQGAMVVHRNLHALDASPNLAAALLVADGDRLPQDPTINLGSVTSVPGAGKGVAQDWPILAHAPAPLPVTMGSRTISVCDLGDAVCDYDPDAEDEMNPAAVAVHTSYARSATDSWTLPLYQIVDATPGSVVPVDPPAGQIVASAGS
>NZ_AP022570.1|WP_163673168.1|1640568_1641387_+|SHOCT-domain-containing-protein
MSTFWRYVRVQLFVLLCGIVGPIFLAAYFLLGADPTLKWMFWTGLGITAADVLIALAITGYGAKAAARTEALEASGVLALAQVTGIHETNTRINDNPLVKLDLHVSGPGFTAFATQDQVIASVGRLPMITNRKLVTLVDPATHEYRIDWERSALVSGMMPATFSVSEDNRTYDLTGQVEPLMEILQVLKAHRIDLDNMIDIRSNPAARQQVQEIVRRAAEVMPPPVAASAPFSGPAEPTTGQRLQELETLRATGSITEDEYRAKREQIIAEL
>NZ_AP022570.1|WP_163673169.1|1642396_1643602_-|ornithine--oxo-acid-transaminase
MSTRTEDTIALDRRHVAHNYAPLPVVAASALGAWITDVEGRRYLDCLAAYSAVNFGHRNPEVIAAAHAQLDALTLVSRAFHSDRLAPFCAALAQLCGKDMVLPMNSGAEAVESAIKVARKWGADVKGVPAGQGTIIVARNNFHGRTTTIISFSDDDTARRGFGPYTPGFRSVEFGDADALADAIDDHTVAVLLEPIQGEAGIVVPPGDYLPRVRRLCTQHDVLMIADEIQSGLARTGRTFACDHWSVVPDVYLLGKALGGGVVPLSAVVADEHVLGVLHPGEHGSTFGGNPLAAAIGTTVVDILRRGEFQRRSAELGAHLHDRLQGLTGRGVLDVRGKGLWAGVDIDPALGSGKQVSLRLAERGVLVKDTHGSTLRFAPPLVITADEIDWAVDQLAEVLGH
>NZ_AP022570.1|WP_163673170.1|1643616_1644507_-|N-dimethylarginine-dimethylaminohydrolase
MTLTDATTDATTDARTTRTPEATSVVDTDRRSARPRRYVMAPPTFFAVEYVINPWMDPSAPVDAALAAQQWDALRQVYLALGHTVDLLEPVAGLPDMVYAANGGVIVNGRAVVARFAYDGRAGEAPAHRDWMAKAGYAPAHTRHINEGQGDLLVVGATILAGHGFRTDRRAHDEIAAHTGLPVISLELVDPRFYHLDTALAVLDDATIAYYPPAFAEPSRTMLTELFPDAIEVCSADAFVLGLNVVSDGLNVVLPAAATGFAEQLRALGFRPVGVDLSELLKGGGSVKCCTLEVHP
>NZ_AP022570.1|WP_163673171.1|1644619_1645066_+|Lrp/AsnC-ligand-binding-domain-containing-protein
MERLEETDERILVELADHARATFAEIGQRVNLSAPAVKRRVDRMLDTGVIRGFTTIVDRNALGWTTEAYVQVYCQGTIAPDELRAAWRDIPEVVSAATVTGTSDAILRVLARDMRHLEEALERIRASASIERSESIVVLSNLIDRAPG
>NZ_AP022570.1|WP_163673172.1|1645134_1646328_+|FAD-dependent-oxidoreductase
MTTSEGQSGLDGVVIVGGGLAAARTAEQLRRAEYTGAITIVSDENHLPYDRPPLSKEVLRAETDDVTLKPAEFYADNDITVLLGNGARSVDTVAKSLTLADGTTLGYDELVIATGLVPKRIPSFPDLPGIHVLRSLDESRALRSEARDATRAVVVGAGFIGCEVAASLRTLDVNVTLVEPQPAPLASVLGEQIGGLITRLHRAEGIDVRCGVGVAEVSGDDRVRTVTLSDGSELDADLVIVGIGSKPATDWLEDSGITIDNGVVCDEVGRTTAPHVWAIGDVASWLDVVAGQVRVEHWSNVADQARAMVPAMLGHEASAAVTVPYFWSDQYDVKIQCLGEPEATDTVHIVEDDGRKFLAYYERDGVVVGVVGGGMPGKVMKTRAKIAAGAPIGDVLG
>NZ_AP022570.1|WP_163673173.1|1646459_1647851_-|glyoxalase
MNDDPLDVLSDGDLPVAPDPGFATRLRARLEAAANLFEQQPDRTEGVIMSGTDTALADLTTSTPRPAATTTPRPAATTTPRPAATSTPRPAATSTPRPAATSTPRPAAVPYLAVSDARAALTWYQQALGATIIGDPIEMGDGRIGHAELALAGGVLYLADEFPEIGLKAPRPQEVSVSLMLAVPDTDVALERAREKGADVQREPYEAHGGRNATIVDPFGHRWMLSGPATGAAAPIQHGDVGFVSVWTPDVERAASFYGHVLGWIYDPATQLVTNTDQHIGLSSVPDRSTLCCCYAVADLAGARDSIATGGGRVGEEREFAFGTVLDATDPQGLEFAVFQPRTGEPRPALNGTGPGELSYLTYQVPDSASFKAFYSRVLFWAFEPGRIDDGWQVTPTHPMAGMAGGNETATVVPMWTVEDIDAAVSRVRQAGGTVIEEPSVQPYGKSALCTDDQGTRFYLGEL
>NZ_AP022570.1|WP_163673174.1|1647847_1648366_-|sigma-70-family-RNA-polymerase-sigma-factor
MSAEPDDHGPRALLTLYDDALPVVYGYFVRRCSDRGTAEDLTSETFLAAMDAARKPNPPSFSVPWLIGVARHKLADHYRRRHDRFTVPVAEPPEHDPTDTWDIELDRIVAEQVLSQLPEHHRTVLALRYMDDCSVPECAELIGRTVHATEALLVRARRAFRAQYPTLEGGMP
>NZ_AP022570.1|WP_163673175.1|1648568_1649147_-|mycofactocin-system-transcriptional-regulator
MPAAKARVGRRRSTSWEHISDVAIDLFMARGFDEVSVDDVAAAAGIGRRTLFRYYPSKNALPWGDFDAHLDHMRALLDALEPSVPMRDALRTALLAFNEFDDTDRHRERMRLILQTEALQAYSMTMYAGWRAVVAAFVAARLNCSAADLVPQTVAWTMLGVALAAYENWLADEAVALSAALGNAFDTLAAGL

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Crispr_ID: NZ_AP022570_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022570_6

1855647-1855739

Orphan

Consensus_repeat	Method
CCCTCGCCCGCTTCGTCGTCAGCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022570_6

>merge|NZ_AP022570|6|1855647-1855739|CRISPRCasFinder
CCCTCGCCCGCTTCGTCGTCAGCTTCGTCGTCAGGCGGTGTTGGATTGCCCGACTCCTCACGGGCTCGTCCCTCGCCCGCTTCGTCGTCAGGC

>NZ_AP022570|6|6|1855647-1855739|CRISPRCasFinder
CCCTCGCCCGCTTCGTCGTCAGCT	TCGTCGTCAGGCGGTGTTGGATTGCCCGACTCCTCACGGGCTCGT
CCCTCGCCCGCTTCGTCGTCAGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022570.1\|WP_163673309.1\|1860683_1861550_+\|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase	unknown	unknown	gnl\|CDD\|237637
NZ_AP022570.1\|WP_163673304.1\|1853759_1854980_+\|hemin-transporter	unknown	unknown	gnl\|CDD\|237337
NZ_AP022570.1\|WP_163679981.1\|1854976_1855453_-\|TetR/AcrR-family-transcriptional-regulator-C-terminal-ligand-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|379883
NZ_AP022570.1\|WP_163673301.1\|1851704_1852076_+\|DUF742-domain-containing-protein	unknown	unknown	gnl\|CDD\|283084
NZ_AP022570.1\|WP_163673308.1\|1859444_1860653_-\|NADH:flavin-oxidoreductase	unknown	unknown	gnl\|CDD\|239201
NZ_AP022570.1\|WP_152516014.1\|1866640_1867033_-\|ectoine-synthase	unknown	unknown	gnl\|CDD\|183953
NZ_AP022570.1\|WP_163673311.1\|1864332_1865556_+\|fatty-acid-desaturase	unknown	unknown	gnl\|CDD\|225779
NZ_AP022570.1\|WP_170311198.1\|1861546_1861840_+\|DUF3017-domain-containing-protein	unknown	unknown	gnl\|CDD\|378602
NZ_AP022570.1\|WP_163673300.1\|1851283_1851697_+\|roadblock/LC7-domain-containing-protein	unknown	unknown	gnl\|CDD\|224929
NZ_AP022570.1\|WP_163673312.1\|1865725_1866616_-\|ectoine-hydroxylase	unknown	unknown	gnl\|CDD\|131461
NZ_AP022570.1\|WP_163673306.1\|1858449_1858845_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|378915
NZ_AP022570.1\|WP_163673307.1\|1858894_1859461_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_AP022570.1\|WP_152516011.1\|1863195_1864323_+\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|99812
NZ_AP022570.1\|WP_163679978.1\|1846076_1846754_+\|FCD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224715
NZ_AP022570.1\|WP_152515999.1\|1846858_1848379_+\|cytosine-permease	unknown	unknown	gnl\|CDD\|271404
NZ_AP022570.1\|WP_163673310.1\|1861875_1862811_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_AP022570.1\|WP_163673302.1\|1852056_1852632_+\|ATP/GTP-binding-protein	unknown	unknown	gnl\|CDD\|225138
NZ_AP022570.1\|WP_152516003.1\|1852636_1853191_+\|pentapeptide-repeat-containing-protein	unknown	unknown	gnl\|CDD\|224276
NZ_AP022570.1\|WP_163673303.1\|1853286_1853763_+\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|236820
NZ_AP022570.1\|WP_163673299.1\|1848617_1851287_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|340391

Protein	Function_ID	Function_description	E-value
NZ_AP022570.1\|WP_163673309.1\|1860683_1861550_+\|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase	gnl\|CDD\|237637	PRK14193, PRK14193, bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional.	0
NZ_AP022570.1\|WP_163673304.1\|1853759_1854980_+\|hemin-transporter	gnl\|CDD\|237337	PRK13289, PRK13289, NO-inducible flavohemoprotein.	4.06864e-107
NZ_AP022570.1\|WP_163679981.1\|1854976_1855453_-\|TetR/AcrR-family-transcriptional-regulator-C-terminal-ligand-binding-domain-containing-protein	gnl\|CDD\|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	2.09696e-20
NZ_AP022570.1\|WP_163673301.1\|1851704_1852076_+\|DUF742-domain-containing-protein	gnl\|CDD\|283084	pfam05331, DUF742, Protein of unknown function (DUF742). This family consists of several uncharacterized Streptomyces proteins as well as one from Mycobacterium tuberculosis. The function of these proteins is unknown.	1.65409e-26
NZ_AP022570.1\|WP_163673308.1\|1859444_1860653_-\|NADH:flavin-oxidoreductase	gnl\|CDD\|239201	cd02803, OYE_like_FMN_family, Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Members of OYE family include trimethylamine dehydrogenase, 2,4-dienoyl-CoA reductase, enoate reductase, pentaerythriol tetranitrate reductase, xenobiotic reductase, and morphinone reductase.	1.04768e-107
NZ_AP022570.1\|WP_152516014.1\|1866640_1867033_-\|ectoine-synthase	gnl\|CDD\|183953	PRK13290, ectC, L-ectoine synthase; Reviewed.	7.93024e-80
NZ_AP022570.1\|WP_163673311.1\|1864332_1865556_+\|fatty-acid-desaturase	gnl\|CDD\|225779	COG3239, DesA, Fatty acid desaturase [Lipid metabolism].	1.34997e-46
NZ_AP022570.1\|WP_170311198.1\|1861546_1861840_+\|DUF3017-domain-containing-protein	gnl\|CDD\|378602	pfam11222, DUF3017, Protein of unknown function (DUF3017). This bacterial family of proteins with unknown function appear to be restricted to Actinobacteria.	4.96438e-14
NZ_AP022570.1\|WP_163673300.1\|1851283_1851697_+\|roadblock/LC7-domain-containing-protein	gnl\|CDD\|224929	COG2018, COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only].	2.36327e-27
NZ_AP022570.1\|WP_163673312.1\|1865725_1866616_-\|ectoine-hydroxylase	gnl\|CDD\|131461	TIGR02408, putative_L-proline_4-hydroxylase, ectoine hydroxylase. Both ectoine and hydroxyectoine are compatible solvents that serve as protectants against osmotic and thermal stresses. A number of genomes synthesize ectoine. This enzyme allows conversion of ectoine to hydroxyectoine, which may be more effective for some purposes, and is found in a subset of ectoine-producing organisms.	4.178e-148
NZ_AP022570.1\|WP_163673306.1\|1858449_1858845_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	2.31581e-10
NZ_AP022570.1\|WP_163673307.1\|1858894_1859461_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.60525e-10
NZ_AP022570.1\|WP_152516011.1\|1863195_1864323_+\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	gnl\|CDD\|99812	cd06216, FNR_iron_sulfur_binding_2, Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently bound FAD as a prosthetic group) are present in chloroplasts, mitochondria, and bacteria in which they participate in a wide variety of redox metabolic pathways. The C-terminal domain contains most of the NADP(H) binding residues and the N-terminal domain interacts non-covalently with the isoalloxazine rings of the flavin molecule which lies largely in a large gap betweed the two domains. Ferredoxin-NADP+ reductase first accepts one electron from reduced ferredoxin to form a flavin semiquinone intermediate. The enzyme then accepts a second electron to form FADH2 which then transfers two electrons and a proton to NADP+ to form NADPH.	4.76918e-116
NZ_AP022570.1\|WP_163679978.1\|1846076_1846754_+\|FCD-domain-containing-protein	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	8.23728e-39
NZ_AP022570.1\|WP_152515999.1\|1846858_1848379_+\|cytosine-permease	gnl\|CDD\|271404	cd11555, SLC-NCS1sbd_u1, uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).	0
NZ_AP022570.1\|WP_163673310.1\|1861875_1862811_-\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	2.89704e-46
NZ_AP022570.1\|WP_163673302.1\|1852056_1852632_+\|ATP/GTP-binding-protein	gnl\|CDD\|225138	COG2229, COG2229, Predicted GTPase [General function prediction only].	1.72775e-52
NZ_AP022570.1\|WP_152516003.1\|1852636_1853191_+\|pentapeptide-repeat-containing-protein	gnl\|CDD\|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	1.34787e-19
NZ_AP022570.1\|WP_163673303.1\|1853286_1853763_+\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|236820	PRK11014, PRK11014, HTH-type transcriptional repressor NsrR.	4.89245e-29
NZ_AP022570.1\|WP_163673299.1\|1848617_1851287_+\|HAMP-domain-containing-protein	gnl\|CDD\|340391	cd00075, HATPase, Histidine kinase-like ATPase domain. This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.	1.5214e-19

>NZ_AP022570.1|WP_163679981.1|1854976_1855453_-|TetR/AcrR-family-transcriptional-regulator-C-terminal-ligand-binding-domain-containing-protein
MEGAANRAQLTPDFFRQTWGSERQLIVDALLNYTREITEMPDTGSLHGDLSALTHCIARYLNDPVGRRIARMMVVDSKSYEVDVETRAQFWATRQQAVNEILRRAEARGELRDDVRPTVVMQLVSSPLHTLALYSDRPATHDYCQAIADLVARAVTRA
>NZ_AP022570.1|WP_163673304.1|1853759_1854980_+|hemin-transporter
MTETIVAAELEPAHAEVISATLPLVGAHIDEITREFYRRMFAAHPELLRNLFNRGNQAQGAQQRALAASIATFATHLVDPALPHPAELLARIGHKHASLGVTADQYPIVHEHLFAAIVEVLGADTVTAEVAEAWDRVYWIMADTLIELERGLYRAAGVGEGDVYRRARVVSRVDDPSGTVLVTVRTDGQSSGFAPGQYVSVGVTMPDGARQLRQYSVVNHPGTGGLTFAVKPVVAAAGQPAGEVSSWIASNLRVGDILDVTVPFGDLPAPTGTEPLVLISAGIGATPMIGVLEYLAVEAPDARVHVLHADRSAQSHPLRGRQRELTDRLPNATLEVWYEDGVGADAPDAHAGLMDLDAVPLAADAQIYLCGNNGFVQAVRAQLVHRGVPASRVHCELFSPNDWLLG
>NZ_AP022570.1|WP_163673303.1|1853286_1853763_+|Rrf2-family-transcriptional-regulator
MQLTRFTDLGLRAVMLLAAGEADGRRVTTGSIAAGANASENHIAKAVARLSDLGLVSARRGRVGGLSLTDEGRNASIGWLVRRLEGDREVVECGGSAPCRLVPACRLRRALADAKEAFYRELDHYTVNDLARGATLPVLAVPAVPRPHHPTTERTDHP
>NZ_AP022570.1|WP_152516003.1|1852636_1853191_+|pentapeptide-repeat-containing-protein
MRDVETDREFTGEDFRDEDLSRLRTERVVFTECDFSGVDMSESEHEGSAFRNCTFRRTSLWHSTFRHCTFLGSTFVECRMRPLTLVEVDFTLAVLGGADLRELDLSDCRLREAGLVGTDLRRAVLARCDLTGARVQGARMDGADLRGARTDASLWTTAGLRGAKVDVEQAVRFAAAHGLDIHGG
>NZ_AP022570.1|WP_163673302.1|1852056_1852632_+|ATP/GTP-binding-protein
MASGRSSGQASTKIVISGGFGAGKTTFVGAVSEIVPLRTEALVTNASEGVDGLEATPSKSTTTVAMDFGRISLGDDLVLYLFGTPGQRRFWFMWDDLVRGAIGAIILVDTRRLADSFAAVDFFEARRLPFLVAVNEFDDAPRHRLSAVREALALSEQVPIVRVDARSRESAKAALIAVTEYALSRLPAAAS
>NZ_AP022570.1|WP_163673301.1|1851704_1852076_+|DUF742-domain-containing-protein
MAGDGDRGAGEPSLVRPYTLTAGRTDAQVELALEAAVGVVAAVPPPRWPSTDVRCQILALCARRPSVAEIAAHLSLPLGVARVLVGDLVVQGYVQVHATLGEADTVDARRELIGRTLRGLRAL
>NZ_AP022570.1|WP_163673300.1|1851283_1851697_+|roadblock/LC7-domain-containing-protein
MTPQPQSERDSLDWLVSRFARDVSGVSHAVLVSADGLLIAASERMPGERADQLAAVTSGLASLSTGAAQLFDGGYVLQSVVEMENGYLLLMRVGDGSNLAALATRHSDIGQIGYEMAMLVERVGAVVSPQRRTPQHS
>NZ_AP022570.1|WP_163673299.1|1848617_1851287_+|HAMP-domain-containing-protein
MKSADRPSRVALSNWPVRWKVLAIAAVPLILAGVFGGLRIHSSVTEAGELQQAAERAEMVPAVADYMGALEQAMVTATQGGDTGSALTVYGSARSELERRVADTDLQDSTRLAANTLLDYGQDLLDEISANTIDLRGRVTTYAPLLLTAETAITGLVDADDQTVQAEGDALARAVGARGQMAMQQMLVTSGGGLPEPELRSAMITIAGTEPSTVSAMGGYFGGATDQAASLRSEMVRRMSVLSDPASALVGNPDLLASQQVTREIADGLIAQTTHSIPTTVDRQAAAARTAAIRDAALVGAAIVVALLLVTLVARTLVRPLRTLRDSALKVAHEDLAREVEHVRTDGKTFPIQPVPVHTSEEVGQVAHAVDELHEQAVLLAGEQARLQLQVTDMFETLSRRNRTLVDQQLSLIDQLERDEEDPDRLQSLFRLDHLAARMRRNGANLMVLAGARIPREQAEPVALTAVVNAAASEVEDYTRVEPVDLPDTEVSGAVAGDLVHLLAELLDNALRYSPPANPVRVSAVHTGNGGLVLEVSDTGLGMTESDLRVANTRLESGGEVNPYTARHMGLFVVGRLATQHGLVVRLRSTTATREPGAGTTAGVYVPATLLASRSQRRPAVTAAPAAVPAAAGPAPAPSKVTPDPAPAELPRRRPGSSGMGGVTKRTEQPVPPQRSDVAAFFAPNPERVWSPPVTEDVPPPPVIEDVPPPVAEDVPPPVTEDVPPRAAEDDIREARAADTAGTAEDDDAIYQKMLSEWLVDPHELSQNPDLNWKSVWDHGWSAAAAAEKTPVSAHTVDGLPVRQPGARLVPGAAGQDSHHHGGHPVASPVSHDRSHDRNGNETGNGAGNGAHGRHLRDPDAVRTSIGRHFGGVHAARAKVQETGGAHAE
>NZ_AP022570.1|WP_152515999.1|1846858_1848379_+|cytosine-permease
MTTEAAPLTAGTHTGPAGTSIIKPSYHPRLTNEDLAPLVEQKWNWYNIFAFWMADVHSVGGYVTAGALFALGLTSWQVFVCLIVGICIVQLFCNLVAKPSQVHGLAYPVVARAAFGVMGANIAAIIRGSIAIAWYGVQTFLAAGSLTIVILKLFPGLQAYATDDNSFLGLSYVGYLSFAILWVIQAVVFWWGMEMVRWLCDISGPLIYTMMFILCIYMMARADWQISLTLSDKQLSTAEQLGAMLGAIALVVSYFAGPMLNFGDFSRYAKSFQQLKLGNLIGLPINFVVFSLLVVLTASATLPVFGEVMTNPIDTVQAIDTYTAVLLGGFTFVLATIGINIVANFVAPAFDFSNVNPQKISWRTGGMIAAVGSVLLTPWNWYNNDEAIFWTLGLLGALIGPLFGILIADYYLVRKQHIVVDDLFTMEESGTYWYQRGFNPVAIKATIVAGIASIGSVVIPKITGVVPTLGQYSWFIGCLVGFAAYYLFAYRANVANVAGRDVVEAG
>NZ_AP022570.1|WP_163679978.1|1846076_1846754_+|FCD-domain-containing-protein
MRLQNSFTQSGQSHVVDDLRHAILSGDQPPGTVIPVDEVAAHLGVSPIPVREALMTLIGEGLVERRPHVGYRVTTLTFEEFTDLYEVREVLEASALVSSVRNAGVDDDVQIRASHTELETAIRRSDHRSFHTESRRLHLAMMRPSKMSRLISMYESAWNLTEPTSPMSHVSDEARRQFHGDHAEMIAAFVDRDVDALVAASHRHYEHLRAGFDPLRGDAELFRGP
>NZ_AP022570.1|WP_163673306.1|1858449_1858845_-|nuclear-transport-factor-2-family-protein
MNTATAVAEQLYRALSDGDADALSAALSADFHATVSAGMPHDVGGEHHGRVAMIAGVWGRIDAIYDLAVVPSEFLEIGGGNKVVVLGTYRGTARDGTTRVDAAFAHVIAVRNGRITALQQITDTVRWSIPA
>NZ_AP022570.1|WP_163673307.1|1858894_1859461_+|TetR-family-transcriptional-regulator
MPRPARYSVDTLLDVAAELLAAEGPSAVTMSAVARAAGAPSGSVYHRFPTRAALCGELWVRTEERFQEALIDALSEDRDDAQQRCVAGALRIVQWCRENSTEAQVLLAGPHELGLGDWPDPIAGRRKRLQRKLRKAMAGLPDEEGRVSAAVIDVPGAIVRRHLRARQSIPASAETIVADCARALIPPG
>NZ_AP022570.1|WP_163673308.1|1859444_1860653_-|NADH:flavin-oxidoreductase
MTAPNDVFTAAKLGPITLRNRVIKAATFEASTPNALVTDDLITYHRLPAAGGVGMTTVAYLAVSPGGRTEGNQIYWRPEAIPGLRRLTASIHTEGAAISAQIGHAGPVANARSNKATALAPVRFFNPLSMRFARHATRDDIDDVMAAHAAAARYAIDAGFDAVEVHLGHNYFASSFLSPLINRRTDEFGGSLANRAKVARGTVLAVRRAVEKAGTPIAVTAKLNMADGVRGGISTEEALQTAKWLEEDGGLDAIELTAGSSLVNPMYLFRGDVPIKEFAGSFKPPLRWGIRMTGTKFLREYPYREAYLLRDAKLFRAELSMPLILLGGITNRQTMDLAMAEGFDFVAMGRALLAEPDLLNRIQADGDAVKSVCTHCNQCMATIYSHTHCVVTGAPDTVTPGV
>NZ_AP022570.1|WP_163673309.1|1860683_1861550_+|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase
MAAVGAITLDGKATRDEIFVDLTERVKKLTDSGRTPGLGTVLVGDDPGSQAYVRGKHSDCAKVGINSIRRDLPADISQSALEEVLDELNDNPDCTGYIVQLPLPKHLNENAALERVDPGKDADGLHPMNLGRLVLNEPAPLPCTPRGIVHLLRRYQVEIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTATRHLPQITREADIIVAAAGVPHMVTAEMVRPGAAVIDVGVSRDDAGKLVGDVQPGVWDIAGHVSPNPGGVGPLTRAFLLTNVVERAEAAAAS
>NZ_AP022570.1|WP_170311198.1|1861546_1861840_+|DUF3017-domain-containing-protein
MTLKDVARKVFAGQWPILVVGMFLVAAFGLVAFGYWRRGAAVMAVGVGVAAGLRLMLSEDRVGLLAVRSRTVDVVTTASVSAAMLYIAWTIDPLGTS
>NZ_AP022570.1|WP_163673310.1|1861875_1862811_-|diguanylate-cyclase
MITASSLLALDLPVMTGYVFVGLFTGFAAAMTAFWLTRWPTRRQSALTMSAGILLISAWSVVQPSSALAVLGCTATTVTGGYVAFFHSLRLLVFNFCVALATAVAACWRLGAETNLATAFAAFGVIVFLNASVPLAIAGATRALGTYAMRSDVDPLTGLLNRRGFTDVLLRRLERDTPAGDDLVVAMVDLDGFKSLNDSRGHAAGDRALRAVGELLVQAGPPGSAVCRAGGEEFLVAAIGSAETIEGDVHRLCEHIAELPHHVTASVGISTAALAQLPGDDGSPQIDQLIENADSAMYVAKRNGGNRVHRA
>NZ_AP022570.1|WP_152516011.1|1863195_1864323_+|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein
MSAIKALARWSKAPARDVDTASGPWVNIVRGLAARATTPLLPDDYLSLLNPLWSARELRGEIVAVRRETEDTATVFIRPGWGFAGDYQPGQYVGIGLRVNGRWHWRSYSLTSVPEQDGEQISITVKATPEGFLSTHLVNGVEPGTVIRLAAPKGDFALPDPPPPALLFISAGSGITPIMGMLRSLRAREQHPDIVHVHSAPSADAVIFHDELRELEGKQDGYRLHLQLTDSAGHVDFAQFDTVVPDWRERSAWACGPAAMLDDVENLWKEHGLDSELHMERFTIAATDKGGEGGTVTFAISDKQVEIDGATTLLEAGEQVGIQMPFGCRMGICQTCVLPLDGGNVRDIRSGDEHGAGDRIQTCISTASGDCTINI
>NZ_AP022570.1|WP_163673311.1|1864332_1865556_+|fatty-acid-desaturase
MAITDIKAYAHLTDEDIDALAAELDAIRAEVEESRGERDARYIRRTIQLQRALAAGGRIALFASSSRLARIAGTAMLASAKIIENMELGHNVIHGQWDWMNDPEIHSTEWEWDTACPSAQWKHSHNFVHHKYTNVVGLDSDVGYGIMRVTRDEPWEPWMIGNLVYNLLLGTLFEWGVALHHIETEKIRNKEKTWAQAMKDLRVMGKKMGRQAGKDYLVYPALAGTNWKSTLKCNVVANLIRNYWAYMVIFCGHFPDGAEKFTVEEFENETRGEWYLRQMLGSANFNAGPVMAFMSGNLCYQIEHHLFPDLPSNRYAEMSVRVRELCEKYDLPYTTGPLARQYWQSFWTILKLALPDRFLRATPDNAPETNSERRFAETVPLAETNGDTSGRRRGLRTAIRQRMTTAA
>NZ_AP022570.1|WP_163673312.1|1865725_1866616_-|ectoine-hydroxylase
MNTRTDDHYPTRLDHAIPPIPRIEPGVWGSADQGPLDDEALQSYANGGYLIRPRTVGPDWLPPLSMELNRLGAELDHDDPRVIREPGGGIRSVFEPHLLSDLIAEVVGLETVLPVARQLLGSDVYIHQARINMMPGFTGSGFYWHSDFETWHAEDGMPAIRAVSCSIALTDNYPFNGSLMVMPGSHQTFYPCVGATPDDNYTSSLVSQRIGTPDQDTLVKACDERGIDQFTGPAGTALWFDANLLHGSGSNITPYPRSNVFLVFNSVDNGLVEPFAAKSRRPSFLAARDIVPAGLQ
>NZ_AP022570.1|WP_152516014.1|1866640_1867033_-|ectoine-synthase
MIVRTTDDITGTERDVSDGTWRSKRIILADDAVGFSFHETTIQAGSVNEFHYQYHVEAVWLVEGSGLLTNLETGEEHPLKAGSMYLLNGHERHRIRCDEQMRMLCVFNPPVTGREVHDETGAYPPPAQIA

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Crispr_ID: NZ_AP022570_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022570_7

3732557-3732635

Orphan

Consensus_repeat	Method
GTCGTGAGATGAACCGAGCCGTGAGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022570_7

>merge|NZ_AP022570|7|3732557-3732635|CRISPRCasFinder
GTCGTGAGATGAACCGAGCCGTGAGATGAACCGAGCCGTGAGTCGACCGGGGGTCGTGAGATGAACCGAGCCGTCAGAT

>NZ_AP022570|7|7|3732557-3732635|CRISPRCasFinder
GTCGTGAGATGAACCGAGCCGTGAGAT	GAACCGAGCCGTGAGTCGACCGGGG
GTCGTGAGATGAACCGAGCCGTCAGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022570.1\|WP_163676009.1\|3738339_3738933_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_AP022570.1\|WP_163680399.1\|3734722_3736702_-\|phosphotransferase	unknown	unknown	gnl\|CDD\|367273
NZ_AP022570.1\|WP_163675981.1\|3723389_3723941_+\|dihydrofolate-reductase-family-protein	unknown	unknown	gnl\|CDD\|223340
NZ_AP022570.1\|WP_163675987.1\|3727352_3729737_+\|pyruvate,-water-dikinase	unknown	unknown	gnl\|CDD\|235751
NZ_AP022570.1\|WP_152517483.1\|3732658_3732952_+\|cytochrome-C-oxidase-subunit-IV-family-protein	unknown	unknown	gnl\|CDD\|377083
NZ_AP022570.1\|WP_152517473.1\|3722548_3723325_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187629
NZ_AP022570.1\|WP_163676012.1\|3739030_3741280_+\|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|239163
NZ_AP022570.1\|WP_163675984.1\|3726361_3727348_+\|TIGR03617-family-F420-dependent-LLM-class-oxidoreductase	unknown	unknown	gnl\|CDD\|132656
NZ_AP022570.1\|WP_163676005.1\|3737346_3738336_+\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187539
NZ_AP022570.1\|WP_163676017.1\|3742269_3742749_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176854
NZ_AP022570.1\|WP_163676014.1\|3741280_3742138_-\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|376556
NZ_AP022570.1\|WP_152517485.1\|3736791_3737256_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022570.1\|WP_163675990.1\|3729818_3730484_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_AP022570.1\|WP_152517476.1\|3724584_3725187_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_AP022570.1\|WP_170311208.1\|3724410_3724575_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022570.1\|WP_163676022.1\|3742777_3743215_-\|DoxX-family-membrane-protein	unknown	unknown	gnl\|CDD\|225168
NZ_AP022570.1\|WP_163675993.1\|3730482_3731196_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022570.1\|WP_163675982.1\|3725237_3726353_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022570.1\|WP_163676002.1\|3732913_3734533_-\|cation:proton-antiporter	unknown	unknown	gnl\|CDD\|226998
NZ_AP022570.1\|WP_163675996.1\|3731192_3731987_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP022570.1\|WP_163676009.1\|3738339_3738933_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	4.53596e-10
NZ_AP022570.1\|WP_163676012.1\|3739030_3741280_+\|molybdopterin-dependent-oxidoreductase	gnl\|CDD\|239163	cd02762, MopB_1, The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins.	0
NZ_AP022570.1\|WP_163675981.1\|3723389_3723941_+\|dihydrofolate-reductase-family-protein	gnl\|CDD\|223340	COG0262, FolA, Dihydrofolate reductase [Coenzyme metabolism].	5.02456e-23
NZ_AP022570.1\|WP_163675987.1\|3727352_3729737_+\|pyruvate,-water-dikinase	gnl\|CDD\|235751	PRK06241, PRK06241, phosphoenolpyruvate synthase; Validated.	3.88124e-101
NZ_AP022570.1\|WP_152517483.1\|3732658_3732952_+\|cytochrome-C-oxidase-subunit-IV-family-protein	gnl\|CDD\|377083	pfam03626, COX4_pro, Prokaryotic Cytochrome C oxidase subunit IV. Cytochrome c oxidase (COX) is a multi-subunit enzyme complex that catalyzes the final step of electron transfer through the respiratory chain on the mitochondrial inner membrane. This family is composed of cytochrome c oxidase subunit 4 from prokaryotes.	0.00049511
NZ_AP022570.1\|WP_152517473.1\|3722548_3723325_+\|SDR-family-oxidoreductase	gnl\|CDD\|187629	cd05371, HSD10-like_SDR_c, 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs. HSD10, also known as amyloid-peptide-binding alcohol dehydrogenase (ABAD), was previously identified as a L-3-hydroxyacyl-CoA dehydrogenase, HADH2. In fatty acid metabolism, HADH2 catalyzes the third step of beta-oxidation, the conversion of a hydroxyl to a keto group in the NAD-dependent oxidation of L-3-hydroxyacyl CoA. In addition to alcohol dehydrogenase and HADH2 activites, HSD10 has steroid dehydrogenase activity. Although the mechanism is unclear, HSD10 is implicated in the formation of amyloid beta-petide in the brain (which is linked to the development of Alzheimer's disease). Although HSD10 is normally concentrated in the mitochondria, in the presence of amyloid beta-peptide it translocates into the plasma membrane, where it's action may generate cytotoxic aldehydes and may lower estrogen levels through its use of 17-beta-estradiol as a substrate. HSD10 is a member of the SRD family, but differs from other SDRs by the presence of two insertions of unknown function. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	4.16605e-104
NZ_AP022570.1\|WP_163676014.1\|3741280_3742138_-\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|376556	pfam01510, Amidase_2, N-acetylmuramoyl-L-alanine amidase. This family includes zinc amidases that have N-acetylmuramoyl-L-alanine amidase activity EC:3.5.1.28. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala). The structure is known for the bacteriophage T7 structure and shows that two of the conserved histidines are zinc binding.	6.22602e-23
NZ_AP022570.1\|WP_163675984.1\|3726361_3727348_+\|TIGR03617-family-F420-dependent-LLM-class-oxidoreductase	gnl\|CDD\|132656	TIGR03617, F420_MSMEG_2256, probable F420-dependent oxidoreductase, MSMEG_2256 family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes one such subfamily, exemplified by MSMEG_2256 from Mycobacterium smegmatis. [Unknown function, Enzymes of unknown specificity].	4.23005e-167
NZ_AP022570.1\|WP_163676005.1\|3737346_3738336_+\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187539	cd05228, AR_FR_like_1_SDR_e, uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs. This subgroup contains proteins of unknown function related to aldehyde reductase and flavonoid reductase of the extended SDR-type. Aldehyde reductase I (aka carbonyl reductase) is an NADP-binding SDR; it has an NADP-binding motif consensus that is slightly different from the canonical SDR form and lacks the Asn of the extended SDR active site tetrad. Aldehyde reductase I catalyzes the NADP-dependent reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. The related flavonoid reductases act in the NADP-dependent reduction of flavonoids, ketone-containing plant secondary metabolites. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.69137e-49
NZ_AP022570.1\|WP_163675990.1\|3729818_3730484_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	7.5393e-12
NZ_AP022570.1\|WP_163676002.1\|3732913_3734533_-\|cation:proton-antiporter	gnl\|CDD\|226998	COG4651, RosB, Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism].	7.6508e-58
NZ_AP022570.1\|WP_152517476.1\|3724584_3725187_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.59187e-10
NZ_AP022570.1\|WP_163676017.1\|3742269_3742749_+\|SRPBCC-family-protein	gnl\|CDD\|176854	cd07812, SRPBCC, START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket; they bind diverse ligands. Included in this superfamily are the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, and the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), as well as the SRPBCC domains of phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of this superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	1.1744e-09
NZ_AP022570.1\|WP_163676022.1\|3742777_3743215_-\|DoxX-family-membrane-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	3.16077e-14
NZ_AP022570.1\|WP_163680399.1\|3734722_3736702_-\|phosphotransferase	gnl\|CDD\|367273	pfam02958, EcKinase, Ecdysteroid kinase. This family includes ecdysteroid 22-kinase, an enzyme responsible for the phosphorylation of ecdysteroids (insect growth and moulting hormones) at C-22, to form physiologically inactive ecdysteroid 22-phosphates.	7.0841e-24

>NZ_AP022570.1|WP_163675996.1|3731192_3731987_+|hypothetical-protein
MSTRLARVRWNLTRSPKRELWFSWYVMVVFYNLYGLLFVIVTRVQPPPSPGWGTPTVVAWFTDHQLGLLAGFGAVFLVAGMCGPMNALLAYSMRRMSVSPVFAYSYMIMYALAAVPGMLVMAIAMTVGALRPDRDPEVVMWLYDFAFLSFSGTMGVFLIGSLVWMVAILLDRNGVFPKWFGYLNLCNALTEVVVAPAWMFQRGALAWHGAIAWWINVFVFAFYTCVFIVLLRGMIEREDFGTGPLPDPGPEGAVGHRDPVEAAR
>NZ_AP022570.1|WP_163675993.1|3730482_3731196_+|hypothetical-protein
MMRRTDGELILFWTLPAVALIWISAFFLFPGFLHPMSPTMSAEEVAGFYRDEAARIRYSMILFNWFGVGLVPVVVLLALQVRRMAHRTPILSYSLIACAGGPPALFLIANMFWLLGAFRPDRAPDLTMLFNDLAWITFSVMVSYLIAQCLLLALAIYWDRNDTPVFRPWVAHFNVATAVALMPAAFTALALDGPFAWDGLLSFWLKNIAIATWIIVMGVVLGQTIMRQRRSAEQVSV
>NZ_AP022570.1|WP_163675990.1|3729818_3730484_-|TetR-family-transcriptional-regulator
MNLTRGCRSATRHGSRSATTRSIVRYPDAVTSPHEVRSFRAIRRTAAQTRVLDAALVLIAEHGVSGTSLQMIADAMGVTKAAVYRQFRTKEEIVIAITEREMAALEDALDDAEAGGPRAREVLLDRMVDQAIDRRGVVSALNFDPVIIRLQGEYEPFQRFVERLYATLLGTEAGVEARLHAAILSSAISVCVMHPLVADVDGDTLRVHLKSLTRRMLGLSE
>NZ_AP022570.1|WP_163675987.1|3727352_3729737_+|pyruvate,-water-dikinase
MTAETVEFDDITDARFGGKAAGLAELRRLGLAVPPGFVLAEASAPNAAEVARRRFDRMAAAGTIPVAVRSSAVGEDGVDQSFAGQYDTVLGVDSVDAFAAAVRRCAESVDSQRASAYSGHCTTTMNVVVQQMVDARAAGVVFTADPASGRRDLMVIDAVAGLGEALVDGSASPEHVVLHSDGSTAVHEVTGSAVLTARDVDDIRAGALRAAQHWGRPLDLEWAIDRSGRLWWLQARPITTLPGDLNEMDSPVAGATHVYTRCNIGEMMPGAFCPLTASVSGFAIDYAMQMTQVVARAQPRYESPWLQVGYFYGHMFLNMTEGTALSSGILGNSLEQFSMSICGRVIDELEPKPPQPFRRKLGNTVRLTSHALSAGPAIRRLDRQISGFRIPTSRDPRVVLRQLETGVDLYCDVTLTHVRSSSRAAVAANVLESRLIAKAVKDGRSEEDGRADAMRVMAGAADVESAVMLEELDAVVRTVAADNALAGVFLAAAPEVAVTTLRAADSPSGAALRRFLNRHGHRGYRELCMRDPSWADDPNGLGTMMQAMLQAALDPADRGPVSRESLAPASSSVRLLARLAQGGARGREHTKSKMALMAHALKRGYRHLGELLAGAGRLPDADLVFFFDRTELTRVVDSDDLTDLVERALQRREALAYQDALEFEDVSVGRPTPRVLRRPCAAADGEIVGRPASRGVVEGPVRVAKSIHEARAVQRGEILVAPVTDVGWTPYFTVIAALVTDIGSSVSHGAVVAREYGLPCVVNTLVGTQVLQTGDRVRVDGDHGVVTRLDPTAS
>NZ_AP022570.1|WP_163675984.1|3726361_3727348_+|TIGR03617-family-F420-dependent-LLM-class-oxidoreductase
MKIMTALFGPTDAVQRATLLQEAGASGVFTFEGPHDVFTPLALASTVPGLDVMSNVAIALPRNPIQLAHQANDLQLLSEGRFILGLGTQIRTQIEKRYGAEFDRPVARMKELVGALRAIFATWNTGERLDFRGEFYRHTLMTPTFVPGPNPFGPPPIFLGALGPRLTRATAEVADGLLVMPFGSKRFLHETTMPAVREGLAAAGRSDDDFAVVPEIIVSVGSDERDHTSTRMLLAFYGSTPAYRPVLDAHGWGDLQPELNAMSKQGRWQEMATLIDDEMLHTIAACGTPAEVAAHIRDRVEGVSDRICLYQPGPIAVDALAEIVDALA
>NZ_AP022570.1|WP_163675982.1|3725237_3726353_+|hypothetical-protein
MSLSPLDEYPIHQTPSPIATPATSDRNFYDRSYFNVLDRQGRFMALTGIGYYPRLGVKDAYFLVRRGDTQTALHFSDAVDDDRLNQHVNGYRLEVVEPLQELHLTVAETEGISADLTWRGSFPAALERPHEMLTERRVTLQACRFAQVGTWEGWIDVDGERLTVGHDTSVASRDRSWGIRPVGEPEPAGRPDAAFRGMWWLYLPLAFDDYQLFLILREDPDGHRSLYDCTRRWRDGTVEQLDGVRATIHYTPGTRIPHGAHVEFMNRAGDRIHLDVESKLFAPIAFGSGYGGDTSWGHGTWKDGPFTERVSFDLTDPAVMARAPFSLIDHVASAVCTEADGRTARGAGLFEHGVIGPHHPSGFSDWTDVAG
>NZ_AP022570.1|WP_152517476.1|3724584_3725187_-|TetR-family-transcriptional-regulator
MTADQDTDGKTASRAAPGRPRDSRIDAAIIAATRELIVQTGYSALSLSAIAAHAGTTTAAIYRRWSGKVHLVHEAVLSEDAAFAANGAGDIREDIRALVEAMRSMFDRPEVRVALPGLIADTVADPELHKLMIARLAGNLTAFESRFGQRRRDDELPLLAEVVAGTAIFRILVRPDAVLDDAWVEAMTELITERWPVAAG
>NZ_AP022570.1|WP_170311208.1|3724410_3724575_-|hypothetical-protein
MADDGPGRDSDVGDPVCWLDHVCPECGGFNDDPASPCWRCGTLAAGDTTGSTAL
>NZ_AP022570.1|WP_163675981.1|3723389_3723941_+|dihydrofolate-reductase-family-protein
MRRLIYSFGVSLDGFVNDPGGGIDWSEPDDELHQFHNDRYREFEISLHGRRLYELMAEHWPYVPDSAGSIECEFAALWTEKPKVVFSRTLNEVHWNSTLVQKNAVEEVRALKNGGDGMMEIGGANLAASVMPYGLIDEYQLFVSPVVLGGGTPMFPPLNNRLHLRLAETKNFESVLMLRYVTG
>NZ_AP022570.1|WP_152517473.1|3722548_3723325_+|SDR-family-oxidoreductase
MDVNGTSAIVTGGASGIGAATARLLASQGARVVIADMQAERGQELAHEIGGAFVSVDVTDTAQIEDAVNTAVDLGPLRSLVNSAGIGWAQRTIGKDGEFASAHNLDAYKKVLAINLVGTFDCIRLAATAMSRLDPADSGERGAIVNMTSVAAFDGQIGQAAYSSSKGGVVGLTLPVARDLSAVGIRVNTVAPGLIDTPIYGEGPDSEAFKAKLGESVLYPKRLGKPEELASMVVELITNSYMNAEVVRVDGGIRMPPK
>NZ_AP022570.1|WP_152517483.1|3732658_3732952_+|cytochrome-C-oxidase-subunit-IV-family-protein
MTSTNSRRLLIVWAVLAAMTLVYVWMDHAVDESGTLRASTVVTVTAILIALVKVRIIFREFMEVRHAPAWLRRLTDAWVLLLGAALLGSYFIGTAVA
>NZ_AP022570.1|WP_163676002.1|3732913_3734533_-|cation:proton-antiporter
MTVVAIYLVITFGLGGLALAVRLPPLVGFLAAGFVINALDVAEVPQLDVLADLGVTLLLFAIGLKLDVRILLRREVWLTTSVHMLISVVLGGAALWLAAVAGVAMLVGQSMQTIALLAFALSFSSTVFVVKVLEERGESHALYGRVAIGILVMQDIIAVVFLTATSGHLPSPWALALVGLWPLTRILRKVWSRLGHGEMQSLFGIVMALVPGYALFTAVGLKGDLGALIMGVLLASHPASSELARSLFHIKELLLVGFFVSIGLTGLPDLPTIAVAVLMVLLLPFKAGWYITLLTMMKLRHRTAILAGLSLMNYSEFGLIVVSVGVSVGLLAEAWLVEMSIAVALSFVVSALVNGRGHLMVEKIAARLPAQDEDTLHPEERSGDAGDAEVVVIGMGRVGYAAYQRLTEHYGLRVVGVDYDGPRIGRLDEQGLRVIEGDATDLHFWMQLQRSDSVRMAVLAMPRHGANVTALECLRESGFGGTVAAVARYDDEVAWAKEHGVDIAFNVYAGAGLELADQVAGGERERQSGDGRPDEVRPE
>NZ_AP022570.1|WP_163680399.1|3734722_3736702_-|phosphotransferase
MRPPLIERPTDLTADRLTDILGGAAVRDFTVERIGTGQMSECYRVALTYAEEKAGPASVVLKVAAADPSSRQTGLAMGLYEREVEFYTSTAPGLDGPIAPCYHAAYDPATGAFDLVLGDAAPAVVGDEISGATAEQARLALSQLALVHGPLLDDQTLAANDRVNRESPVNQALIAALYAGFIERYRDQIAEQHREVCERLVQTFDAYLAAEAERNGPRGLIHGDYRLDNMLFGQPGADRPLTVVDWQTVTWGPAFTDVAYFLGCALPIERRREHYDTLLAAYTEALGPAAGVTVDDVREGVRRQSFFGVLMSIVSPMLVERTERGDQMFMAMIARHCQHVLDTDALAILPPPTRPEPLRPGAEDEDSHPPGDEPLWSESWYFDFADLRKDVGGWIRLGLIPNQGHAWINALLCGPGMPTVAVLDFEVALPDDHTRVRTHDAEVRMEVVEPLRTFLVTVRAQGQAYDDPAALLRGEAGRPVAVDFDLTWSTDGVPYQYRVSPRYEIPCRVTGSVTADGRTIELAQVQGQRDHSWAPRDWWAMDWVWSALHLDDGTHLHGVDIHIPGMPPLAVGYLQQPGQPLVELEQIATNATFAPDGLPLTAQLGFGDLAVDITLRGHAPVLLSSPDGRLSRFSRAWGTVETPDGRTGVGWIEWNQNQS
>NZ_AP022570.1|WP_152517485.1|3736791_3737256_-|hypothetical-protein
MGERAGVPTGYDRPRVDPGALALATVAGAVAFILGPGEWDLLAVVVGLMLLFILLAHHLAAPTERTPRAYLLRAAFGATTGLAFCIAVAPAIQYLIVTPFFHAESDEGFSEDAWHTTLVLSVLWFVCAGVLATLEPRIARWLDRPRPKRLPPDH
>NZ_AP022570.1|WP_163676005.1|3737346_3738336_+|NAD-dependent-epimerase/dehydratase-family-protein
MKVLITGGTGFVGAWTAKAAQDAGHEVRFLVRNVGRLSTSAEQIGVDITDHVIGDIADGSTTAQALDGCDAVIHCAAMVSTDPNRADEMLHTNLEGARNILGGAAAAGIDPIVHVSSFTALFRPGLDVLHADLPVVGGSDGYGRSKAAVEAYARGLQDGGAPVAITYPGMVLGPPAGDQFGEAAEGVEAAVKMHGVPGRGAAWIVIDVRDLAALHVALLEPGHGPRRYMAGGRRVSVDRLASMIGAAAGKSLAVFPVPDVALRSAGRLLDVVGPYLPVETPINSAAMQYYTQMPTSDDRPSEEELGIVQRDPAETIADTVAGLERVGRL
>NZ_AP022570.1|WP_163676009.1|3738339_3738933_-|TetR-family-transcriptional-regulator
MRNVPAARRPHRGSRRDPDIDAAVLDATRRLLVTRGYAATSIDLIAITAKVSRPAIYRRWRTKAHLVHEAAFPDLGPDPADDDVAGEIARLCRGALAMYADPVVREAVPGLLHDLSAEPAMRRLIHDRLEAAARRQLAAQLADGVGEGAVRPSVDADTVMDAIAGAAWYAVCVRNVTDLDSAATSLADLVSAGVLSR
>NZ_AP022570.1|WP_163676012.1|3739030_3741280_+|molybdopterin-dependent-oxidoreductase
MGHDVHELAGVGEDGLHLYTCPLCEAMCGLEVHVEDGQVAAIRPNRDDVWSRGHICPKGASLGAVHEDPDRIRRPMIKVDGQWHEVDWDTAFRRCTELLAPVIDRYGIGAVTAYTGNPLAHSFSLARYSAVLLGMSGMPLTYSPGTVDQWPKNLTSHLMYGGWWSFPVPDLERTDLLVVMGANPAASQGSLLAAPDVMGLIRSISERGTVIVVDPVRTRTAERADEWLPINPGTDAALLLAVCHTLFAEDLVDLGTLEPHLDGLETLRTAVADWPPERVSAVTGVAADRIRQLARQLAGTPRAVVYGRIGTCNQEFGSLASWLVDVVNILTGHFDVAGGAMFPTPAAWSVTVQPIPGLEDGAADFGRFRTRVRGAKEVLGQVPVSCLAEEIATPGDGQIRALITVAGNPVLSTPAGHKLDEALPGLDAMIAIDLWLNETTRHADVILPGASPLEQPHHDDLILNFAINSVANYSAPVFARPDQDTPDEWEILIRLTGLCTGTPAEDVDVAAVDDGFFDYLCFTQGLDGAEVRAHYDHGGPERILDLTLRTGPFGDRYGRDPDGLTLDSLKAAPDGVNFGPMVPRIPEVLGTSDAKIRLAPAYLLDDLPRLARRLRRQPDDLVLVSRRHLRSNNSWLHNVGALMKGRDRCTLLMHRDDAARLGLHDGDLVAVTSAGGRIDVPLEVTEAIKPGVVSMPHGWGHGKQGTRLTVANGSPGVNTNILSPPDFLDEPSGNGALNGIPVTVTRAGD
>NZ_AP022570.1|WP_163676014.1|3741280_3742138_-|N-acetylmuramoyl-L-alanine-amidase
MPQAAGWRGDPLWLADVLRAEGLDVAEFAGWRGRGHGDFHDIRGVMVHHTGSDFATAASIAYGRPELPGPLSQVHIGRAGTVTVVAAGVAWHAGVGVYPWLPVNMGNWHTIGIECANSGTAPWAPHRQNWPDAQYFALVNSCAAISRRLGLPAARTIGHKEYAGRAQGKWDPGAIDMDRLRLDVARQIGAPARATSPRPAVPVGRYADVLLYRGTRGRQVAELQRRLKFAYASYAGGLEISGEFDVATEEAVREFQRRTPGLHVDGIVGPATAAALELRLIDVDL
>NZ_AP022570.1|WP_163676017.1|3742269_3742749_+|SRPBCC-family-protein
MSEDPDESRHPLIVRRDTSASRRQVWDIIADGWTYSQWVVGNSRMRAVDPNWPQPGSVIHHSVGVWPLVINDSTRVDVCVPMNKLVLIAKGRPLGAARITLRLSDLDDGGCRIEMSEVPLSPPLSWLPRAAALAAVIPRNRETTWRLGVIAERRGSDQD
>NZ_AP022570.1|WP_163676022.1|3742777_3743215_-|DoxX-family-membrane-protein
MAKMMALSKVNGPLGVFVFRVVLGFLFASHGTVKLFGWPPDGGTVAVVGMWPSWWAGLIELVAGLLVMAGLFTRAAAFLASGTMAVAYFWRHQPDALLPIQNGGESAALYCFAFLMLVFTGGGAWAADDLRRRGVSDPTPHEATT

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

3815556 : 3862490

Shigella_phage(22.22%)

transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_163676198.1\|3815556_3816387_-\|tRNA	tRNA (adenine-N1)-methyltransferase	NA	NA	NA	NA
WP_163676201.1\|3817414_3818212_+	thioesterase family protein	NA	NA	NA	NA
WP_163676203.1\|3818218_3819235_-	R2-like ligand-binding oxidase	NA	NA	NA	NA
WP_163676206.1\|3819149_3819842_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_163676209.1\|3819951_3820269_+	metalloregulator ArsR/SmtB family transcription factor	NA	NA	NA	NA
WP_163676212.1\|3820773_3821415_+	NAD(P)H-dependent oxidoreductase	NA	NA	NA	NA
WP_163676216.1\|3821365_3822742_-	FAD-containing oxidoreductase	A0A2K5B2C5	Erysipelothrix_phage	7.3e-60	31.7
WP_163676218.1\|3822744_3823227_-	DUF4126 family protein	NA	NA	NA	NA
WP_163676221.1\|3823294_3824158_-	ATP phosphoribosyltransferase	NA	NA	NA	NA
WP_163676224.1\|3824161_3824443_-	phosphoribosyl-ATP diphosphatase	NA	NA	NA	NA
WP_163676228.1\|3824554_3826162_-	MFS transporter	O13311	Aichi_virus	2.5e-27	26.5
WP_163676231.1\|3826259_3826943_-	HAD-IA family hydrolase	M1HXP3	Paramecium_bursaria_Chlorella_virus	3.6e-07	25.6
WP_163676234.1\|3827024_3828929_+	purine/pyrimidine permease	NA	NA	NA	NA
WP_163676238.1\|3828929_3829430_+	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	NA	NA	NA	NA
WP_163676241.1\|3829426_3829747_+	hydroxyisourate hydrolase	NA	NA	NA	NA
WP_163676244.1\|3829766_3830945_+	FAD-dependent urate hydroxylase HpxO	NA	NA	NA	NA
WP_163676247.1\|3830950_3831784_+	FAD binding domain-containing protein	NA	NA	NA	NA
WP_163676250.1\|3831780_3834483_+	molybdopterin-dependent oxidoreductase	A0A0P0I429	Acinetobacter_phage	4.6e-42	25.9
WP_163676252.1\|3834509_3836747_-	hypothetical protein	NA	NA	NA	NA
WP_163676255.1\|3837202_3838042_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	3.1e-37	37.1
WP_163676258.1\|3838120_3839419_-\|transposase	IS256 family transposase	NA	NA	NA	NA
WP_163676261.1\|3839556_3839763_-	hypothetical protein	NA	NA	NA	NA
WP_163676264.1\|3839798_3840731_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	4.7e-34	33.0
WP_163673099.1\|3840727_3841018_-\|transposase	transposase	NA	NA	NA	NA
WP_163676268.1\|3841290_3842622_+\|transposase	IS256 family transposase	NA	NA	NA	NA
WP_163676271.1\|3842635_3843598_-	DUF222 domain-containing protein	NA	NA	NA	NA
WP_163676274.1\|3843643_3847408_-	methionine synthase	A0A140XBC7	Dickeya_phage	4.4e-14	54.8
WP_152517579.1\|3847725_3848604_+	PAC2 family protein	NA	NA	NA	NA
WP_163676277.1\|3848637_3849639_-	patatin-like phospholipase family protein	NA	NA	NA	NA
WP_163676280.1\|3849648_3850527_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_163680416.1\|3850695_3851934_-	cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase	A0A2K9L6B7	Tupanvirus	1.2e-32	36.0
WP_163676283.1\|3851995_3852829_-	3'(2'),5'-bisphosphate nucleotidase CysQ	NA	NA	NA	NA
WP_163680420.1\|3852846_3853644_-	SCO1664 family protein	NA	NA	NA	NA
WP_163676286.1\|3853669_3854257_-	DUF3090 family protein	NA	NA	NA	NA
WP_163676288.1\|3854312_3855017_-	MSMEG_4193 family putative phosphomutase	NA	NA	NA	NA
WP_152519750.1\|3855075_3855906_-	undecaprenyl-diphosphate phosphatase	NA	NA	NA	NA
WP_152519751.1\|3855950_3856274_-	hypothetical protein	NA	NA	NA	NA
WP_163676291.1\|3856427_3857420_+	hypothetical protein	NA	NA	NA	NA
WP_163676294.1\|3857416_3857677_+	dihydroorotate dehydrogenase	NA	NA	NA	NA
WP_163676297.1\|3857693_3858758_+	quinone-dependent dihydroorotate dehydrogenase	NA	NA	NA	NA
WP_163676300.1\|3858803_3859334_-	YbhB/YbcL family Raf kinase inhibitor-like protein	NA	NA	NA	NA
WP_163676304.1\|3859367_3860732_-	M20/M25/M40 family metallo-hydrolase	NA	NA	NA	NA
WP_163676306.1\|3861238_3862490_+\|transposase	IS3 family transposase	A0A2P1JR32	Mycobacterium_phage	8.5e-148	81.2

DBSCAN-SWA_2

3865747 : 3932131

Paenibacillus_phage(20.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_163673099.1\|3865747_3866038_-\|transposase	transposase	NA	NA	NA	NA
WP_163676308.1\|3868962_3870306_+\|transposase	IS256 family transposase	NA	NA	NA	NA
WP_163676310.1\|3870952_3871537_+	hypothetical protein	NA	NA	NA	NA
WP_163673099.1\|3873839_3874130_-\|transposase	transposase	NA	NA	NA	NA
WP_163676312.1\|3876112_3877468_+\|transposase	IS256 family transposase	A0A0K2CZ57	Paenibacillus_phage	4.0e-34	29.4
WP_163676314.1\|3878544_3879342_+	ATP-binding protein	U5N3V8	Enterobacteria_phage	1.4e-23	32.5
WP_163676316.1\|3881982_3883221_+\|transposase	IS110 family transposase	Q9JMN8	Wolbachia_phage	1.1e-41	27.4
WP_163680423.1\|3883266_3883506_-\|transposase	transposase	NA	NA	NA	NA
WP_163676319.1\|3883879_3884776_-	mammalian cell entry protein	NA	NA	NA	NA
WP_163676321.1\|3884940_3885492_-	mammalian cell entry protein	NA	NA	NA	NA
WP_163676323.1\|3885488_3886457_-	RDD family protein	NA	NA	NA	NA
WP_163676325.1\|3886453_3887119_-	hypothetical protein	NA	NA	NA	NA
WP_163676327.1\|3887088_3888642_-	MCE family protein	NA	NA	NA	NA
WP_163680426.1\|3888645_3889794_-	MCE family protein	NA	NA	NA	NA
WP_163676330.1\|3889823_3891470_-	MCE family protein	NA	NA	NA	NA
WP_163676332.1\|3891484_3893068_-	MCE family protein	NA	NA	NA	NA
WP_163676335.1\|3893064_3894096_-	MCE family protein	NA	NA	NA	NA
WP_163676337.1\|3894092_3895313_-	MCE family protein	NA	NA	NA	NA
WP_163676340.1\|3895315_3896197_-	ABC transporter permease	NA	NA	NA	NA
WP_163676343.1\|3896198_3896996_-	ABC transporter permease	NA	NA	NA	NA
WP_163676347.1\|3897251_3898358_-	NDMA-dependent alcohol dehydrogenase	E3SJ82	Synechococcus_phage	1.6e-33	28.8
WP_005110592.1\|3898513_3898924_-	SCP2 sterol-binding domain-containing protein	NA	NA	NA	NA
WP_163676348.1\|3899015_3900074_-	DUF4872 domain-containing protein	NA	NA	NA	NA
WP_163676352.1\|3900123_3901269_-	acyl-CoA dehydrogenase family protein	NA	NA	NA	NA
WP_163676354.1\|3901307_3902939_-	long-chain-fatty-acid--CoA ligase	A0A2H4PQU7	Staphylococcus_phage	6.3e-26	25.3
WP_011560574.1\|3902953_3903607_-	transglutaminase domain-containing protein	NA	NA	NA	NA
WP_163680429.1\|3903603_3905061_-	cytochrome P450	NA	NA	NA	NA
WP_163676357.1\|3905176_3906706_-	NAD(P)-binding domain-containing protein	NA	NA	NA	NA
WP_163676360.1\|3906724_3907723_-	alpha/beta hydrolase fold domain-containing protein	NA	NA	NA	NA
WP_163680431.1\|3907728_3909246_-	NAD(P)-binding domain-containing protein	NA	NA	NA	NA
WP_163676363.1\|3909295_3910783_-	NAD(P)-binding domain-containing protein	NA	NA	NA	NA
WP_163676366.1\|3910779_3911703_-	ferritin-like domain-containing protein	NA	NA	NA	NA
WP_163676369.1\|3911716_3912571_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_163676372.1\|3912768_3913332_+	TetR family transcriptional regulator	NA	NA	NA	NA
WP_163676375.1\|3913507_3914377_-	metal-dependent hydrolase	NA	NA	NA	NA
WP_163673099.1\|3921623_3921914_-\|transposase	transposase	NA	NA	NA	NA
WP_163676310.1\|3922007_3922592_+	hypothetical protein	NA	NA	NA	NA
WP_163676378.1\|3924473_3925112_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_163676380.1\|3925271_3925730_+	PaaI family thioesterase	NA	NA	NA	NA
WP_163676382.1\|3925726_3926407_+	TetR family transcriptional regulator	NA	NA	NA	NA
WP_163676384.1\|3926470_3926908_+	hypothetical protein	NA	NA	NA	NA
WP_163676386.1\|3927143_3927326_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_163673099.1\|3931840_3932131_-\|transposase	transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_AP022571

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CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_AP022570

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CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection