CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_AP022573	Mycobacterium saskatchewanense strain JCM 13016	6 crisprs	cas3,WYL,cas4,DEDDh,csa3,DinG	0	5	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_AP022573_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022573_1

460936-461050

Orphan

Consensus_repeat	Method
ACCGGGCTCCTCGGGGGTCTGACCGGCGGCG	PILER-CR
ACCGGGCTCCTCGGGGGTCTGACC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_AP022573_1

>merge|NZ_AP022573|1|460936-461050|PILER-CR,CRISPRCasFinder
ACCGGGCTCCTCGGGGGTCTGACCACTGGCGCGACTGATCTCGGTGGCCTCCTCGGCGGTCTGACCGGCGGAACGAGCGGCCTGACCGGGCTTCTCGGGGGTCTGACCGGGGGCG

>NZ_AP022573|1|1|460936-461050|PILER-CR
ACCGGGCTCCTCGGGGGTCTGACCACTGGCG	CGACTGATCTC
GGTGGCCTCCTCGGCGGTCTGACCGGCGGAA	CGAGCGGCCTG
ACCGGGCTTCTCGGGGGTCTGACCGGGGGCG

>NZ_AP022573|1|1|460936-461043|CRISPRCasFinder
ACCGGGCTCCTCGGGGGTCTGACC	ACTGGCGCGACTGATCTC
GGTGGCCTCCTCGGCGGTCTGACC	GGCGGAACGAGCGGCCTG
ACCGGGCTTCTCGGGGGTCTGACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022573.1\|WP_085253801.1\|446928_447123_+\|50S-ribosomal-protein-L35	unknown	unknown	gnl\|CDD\|234676
NZ_AP022573.1\|WP_085253808.1\|455474_457142_+\|PE-family-protein	unknown	unknown	gnl\|CDD\|376422
NZ_AP022573.1\|WP_085256887.1\|473122_474319_+\|argininosuccinate-synthase	unknown	unknown	gnl\|CDD\|234785
NZ_AP022573.1\|WP_085256889.1\|471689_472616_+\|ornithine-carbamoyltransferase	unknown	unknown	gnl\|CDD\|234835
NZ_AP022573.1\|WP_163645076.1\|462397_467215_+\|PE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376422
NZ_AP022573.1\|WP_085253807.1\|452602_455089_+\|phenylalanine--tRNA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234804
NZ_AP022573.1\|WP_085256886.1\|474422_475832_+\|argininosuccinate-lyase	unknown	unknown	gnl\|CDD\|179143
NZ_AP022573.1\|WP_085256892.1\|468414_469629_+\|bifunctional-glutamate-N-acetyltransferase/amino-acid-acetyltransferase-ArgJ	unknown	unknown	gnl\|CDD\|235441
NZ_AP022573.1\|WP_085253804.1\|448413_449481_-\|DUF2236-domain-containing-protein	unknown	unknown	gnl\|CDD\|226188
NZ_AP022573.1\|WP_085253802.1\|447202_447598_+\|50S-ribosomal-protein-L20	unknown	unknown	gnl\|CDD\|179959
NZ_AP022573.1\|WP_085256885.1\|475934_476996_+\|type-III-polyketide-synthase	unknown	unknown	gnl\|CDD\|225958
NZ_AP022573.1\|WP_085256893.1\|467374_468418_+\|N-acetyl-gamma-glutamyl-phosphate-reductase	unknown	unknown	gnl\|CDD\|234761
NZ_AP022573.1\|WP_085256888.1\|472612_473107_+\|arginine-repressor	unknown	unknown	gnl\|CDD\|235116
NZ_AP022573.1\|WP_085253809.1\|457417_458974_+\|PE-family-protein	unknown	unknown	gnl\|CDD\|376422
NZ_AP022573.1\|WP_085256891.1\|469625_470513_+\|acetylglutamate-kinase	unknown	unknown	gnl\|CDD\|234869
NZ_AP022573.1\|WP_085253805.1\|449682_450612_+\|adenylate/guanylate-cyclase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143636
NZ_AP022573.1\|WP_085253823.1\|459165_460212_+\|PE-family-protein	unknown	unknown	gnl\|CDD\|376422
NZ_AP022573.1\|WP_085253806.1\|451559_452603_+\|phenylalanine--tRNA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|234780
NZ_AP022573.1\|WP_085256890.1\|470509_471697_+\|acetylornithine-transaminase	unknown	unknown	gnl\|CDD\|235112
NZ_AP022573.1\|WP_085253803.1\|447610_448390_+\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|223640

Protein	Function_ID	Function_description	E-value
NZ_AP022573.1\|WP_085253801.1\|446928_447123_+\|50S-ribosomal-protein-L35	gnl\|CDD\|234676	PRK00172, rpmI, 50S ribosomal protein L35; Reviewed.	1.30145e-20
NZ_AP022573.1\|WP_085253808.1\|455474_457142_+\|PE-family-protein	gnl\|CDD\|376422	pfam00934, PE, PE family. This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.76171e-27
NZ_AP022573.1\|WP_085256887.1\|473122_474319_+\|argininosuccinate-synthase	gnl\|CDD\|234785	PRK00509, PRK00509, argininosuccinate synthase; Provisional.	0
NZ_AP022573.1\|WP_085256889.1\|471689_472616_+\|ornithine-carbamoyltransferase	gnl\|CDD\|234835	PRK00779, PRK00779, ornithine carbamoyltransferase; Provisional.	0
NZ_AP022573.1\|WP_163645076.1\|462397_467215_+\|PE-domain-containing-protein	gnl\|CDD\|376422	pfam00934, PE, PE family. This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.41241e-25
NZ_AP022573.1\|WP_085253807.1\|452602_455089_+\|phenylalanine--tRNA-ligase-subunit-beta	gnl\|CDD\|234804	PRK00629, pheT, phenylalanyl-tRNA synthetase subunit beta; Reviewed.	0
NZ_AP022573.1\|WP_085256886.1\|474422_475832_+\|argininosuccinate-lyase	gnl\|CDD\|179143	PRK00855, PRK00855, argininosuccinate lyase; Provisional.	0
NZ_AP022573.1\|WP_085256892.1\|468414_469629_+\|bifunctional-glutamate-N-acetyltransferase/amino-acid-acetyltransferase-ArgJ	gnl\|CDD\|235441	PRK05388, argJ, bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ.	0
NZ_AP022573.1\|WP_085253804.1\|448413_449481_-\|DUF2236-domain-containing-protein	gnl\|CDD\|226188	COG3662, COG3662, Uncharacterized protein conserved in bacteria [Function unknown].	2.40472e-105
NZ_AP022573.1\|WP_085253802.1\|447202_447598_+\|50S-ribosomal-protein-L20	gnl\|CDD\|179959	PRK05185, rplT, 50S ribosomal protein L20; Provisional.	9.36351e-59
NZ_AP022573.1\|WP_085256885.1\|475934_476996_+\|type-III-polyketide-synthase	gnl\|CDD\|225958	COG3424, BcsA, Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism].	6.08708e-172
NZ_AP022573.1\|WP_085256893.1\|467374_468418_+\|N-acetyl-gamma-glutamyl-phosphate-reductase	gnl\|CDD\|234761	PRK00436, argC, N-acetyl-gamma-glutamyl-phosphate reductase; Validated.	1.67068e-165
NZ_AP022573.1\|WP_085256888.1\|472612_473107_+\|arginine-repressor	gnl\|CDD\|235116	PRK03341, PRK03341, arginine repressor; Provisional.	4.97812e-84
NZ_AP022573.1\|WP_085253809.1\|457417_458974_+\|PE-family-protein	gnl\|CDD\|376422	pfam00934, PE, PE family. This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.28263e-22
NZ_AP022573.1\|WP_085256891.1\|469625_470513_+\|acetylglutamate-kinase	gnl\|CDD\|234869	PRK00942, PRK00942, acetylglutamate kinase; Provisional.	9.39505e-145
NZ_AP022573.1\|WP_085253805.1\|449682_450612_+\|adenylate/guanylate-cyclase-domain-containing-protein	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	6.64755e-33
NZ_AP022573.1\|WP_085253823.1\|459165_460212_+\|PE-family-protein	gnl\|CDD\|376422	pfam00934, PE, PE family. This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	7.66591e-22
NZ_AP022573.1\|WP_085253806.1\|451559_452603_+\|phenylalanine--tRNA-ligase-subunit-alpha	gnl\|CDD\|234780	PRK00488, pheS, phenylalanyl-tRNA synthetase subunit alpha; Validated.	0
NZ_AP022573.1\|WP_085256890.1\|470509_471697_+\|acetylornithine-transaminase	gnl\|CDD\|235112	PRK03244, argD, acetylornithine transaminase.	0
NZ_AP022573.1\|WP_085253803.1\|447610_448390_+\|RNA-methyltransferase	gnl\|CDD\|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	1.25355e-71

>NZ_AP022573.1|WP_085253823.1|459165_460212_+|PE-family-protein
MSFVVVIPDLVTTAAQDLAGIHSALSEAAAAAAGPNTAVVAAAEDEVSAAIASVFGGLGQDYQALCAQAAAFHGQFVNQLAGSAAAYLSTEAASAQQAVSNAVNAAAAAPTDIGGSLGAVLGAYESLFANTAANLSGIGNTWVNVTEPALLQAFATQVSVPQRIAAAFGSGNLSSLLNVTGQSGLGYANLAQQLTTPISVSLTSLSPSGASIAVGFGLPTLLAFDALGAQVNAASAAAASSAAFFSAVQAGNPVGAAIALIDAPANIANGLLNGQETVAVNLPLPGLSLTANVPFTGLFAPLQPWTATATGPGLPLMNTVTVTGPPVGGLVPALLNYVPQLLATALTG
>NZ_AP022573.1|WP_085253809.1|457417_458974_+|PE-family-protein
MSFVFAVPDEVQGAAQNLANIREAIAEASSSIAGPTTGVVAAAQDQVSAAVAAMFGTFGQEYQVLNNQAQAFHDQFVGLLNAGAGAYLGSDVANAQQSLMNAVSAPVQGILGQAGAAAAANGAALGAAAAQPAALLDPIVGGGTIGGSLLGGLGGGSVGASINGVVSALESGNPLSFLSGAAPPNVLGGIPGLPATLQSLESALLPQLFNAGTSPGVPDIAGPYQTLYNNTAANLQAVSGLWSANPAPLLRQFIDNQIAYGQLVATSFQHAATGFAAGVVALPSSFQAAFQALLTGDATGAVTDIGKGFANLFFSGLEFNTNGTVTVLGALGDLLPIAAVPGDVALNFSNVVGTLTDSNISFSFLPPSFSVGLPLALALDAIGAPVTTLSAFASSANAFAEAVQTGNALGAAAALIDAPAVVANGFLNGEQSLTLELPTSLSPIPFTSSLTATVPLGGLLVSLQPVNATAVVAGIPTTIPLAGTEFGGLIPGLYSGSVQLADAISGVVIPGEMLVGRL
>NZ_AP022573.1|WP_085253808.1|455474_457142_+|PE-family-protein
MSFVIATPDLVESAAQSLAGIRSSLAEAAATAASPTTGIVAAAQDEVSVAIASLFGNFGQEFQALSAQAQSFHAQFVSLMNAGAGAYGSAEAANAAQTILGGLDGGVLGGVGQSLGGVVSGGQAALGQLAGNLGVGVNGAVTALGNGSIGAFVGGELQSGAQAISNAIAGAQLTVGGLQTGGAAGVLDGLSSFGATVAGPYQALFTNTVNNLGSIGNTLVSNPFPFLHQLVNNQIFYGQTIATQLATGIQNLPTELANLPAAIQAGIQQIANFNPGAFVQQLINTQIGYAQTIATGLQSAAQDLVTGIQTLPAGLATAFQALLAGDPSSAFSALSSALETAFLPGFSLATLPSGIMSVTPLGPLGDLAPIFNIPGQIAQSFADLLPLGTVPHMMAQNATNLVEAFTNFGTTLDLNALNINFGLPLQLILDGIGGPINGLSAFNSTAVALGSALQTGDLTGALTAFLDAPANVTNAFLNGTTNLLLPSADLGGGLSSAVEIPFGGILTPLTLPTLVINILGTDTPLPLLGGTGVGGIIPGLIGFGPQLAAAIMSTM
>NZ_AP022573.1|WP_085253807.1|452602_455089_+|phenylalanine--tRNA-ligase-subunit-beta
MRVPYSWLREVVAAGAPDWDVAPKDLEQALVRIGHEVEEVQTLGPVDGPLTVGRVTDIEELTGFKKPIRACLVDVGAEEQREIICGATNFAVGDLIVAALPGTILPGGFAIAARKTYGRQSDGMICSAAELGLGADHSGILVLPPGTAEPGADAAAVLGLDDVVFHLAITPDRGYCMSVRGLAREIACAYDLNFVDPADVKPLPADGEAWPLTVHADTGVRRFSLRPVTGIDPDAVSPWWLQRRLLLCGIRATSPAVDVTNYVMLELGHPMHAHDANRITGGLEVRFARPGETVVTLDDIERKLDPADVLIVDDAATAAIGGVMGAASTEVRADSTDVLLEAAVWDPAAVSRTQRRLHLPSEAARRYERGVDPAISVAALNRCATLLVDIAGGAVSDKLTDWRGDPPRDDWAFPPIRIAADLPDRFAGIAYAPGTTAKRLAQIGVLVAGEGDTLTVTPPSWRPDLSQPADLVEEVLRLEGLEAIPSVLPSAPAGRGLTAVQKRRRAVGKSLAQSGFVEILPTPFLPAGVFELWGLPADDSRRRTTHVLNPLEADRPHLATTLLPALLEALTRNVSRGLVDVALYSLAQVVQPTEETGGVELIPVHRRPTDDEIALLDASLPRQPQHVAAVMAGLSERRGPWGPGRRFEAADAFEAVRIVARASGVEVQLRAAQYLPWHPGRCAEVLVGETTVGHAGQLHPAVIERSGLPRDTCAMELNLDAIPLTDLLPAPRVSPYPAVFQDVSLVVSADVPAQAVADAVREGAGELLEDIQLFDVFTGPQIGEHRKSLTFALRFRAPDRTLTEDDASAARDAAVQRAAEVVGAELRA
>NZ_AP022573.1|WP_085253806.1|451559_452603_+|phenylalanine--tRNA-ligase-subunit-alpha
MGDQPVDLSPDALARAVTAAQQAIEQAADLDALARVKTEHLGDRSPLALARQALGALPKDERADAGKRVNVARSEVQRSYDERLATLRAERDAAVLVAEGIDVTLPSTRHPAGARHPITILAEHIADTFVAMGWELAEGPEVETEQFNFDALNFPADHPARSEQDTFYIAPENSRQLLRTHTSPVQVRTLLAHELPVYIISIGRTFRTDELDATHTPVFHQVEGLAVDRGLSMAHLRGTLDAFARAEFGPSARTRIRPHFFPFTEPSAEVDVWFANKKGGADWVEWGGCGMVHPNVLRAAGINPDVYSGFAFGMGLERTLQFRNGIPDMRDMVEGDVRFSLPFGVGA
>NZ_AP022573.1|WP_085253805.1|449682_450612_+|adenylate/guanylate-cyclase-domain-containing-protein
MEVARRDPDSGEPDDAVQTQAQPTPRRLPPASVHTATQWLKGRNHNPGAVAFLRRARRLLPGDPEFGDPLSTAGDGGPRAAARAADRLLGDRDAVSREVSLGVLQVWQALTEAVSRRPANTEVTLVFTDLVGFSTWSLNAGDEAALSLLRQVARAVEPPLLDAGGHIVKRMGDGIMAVFRDPTVAVRAVLEAKAALKSVEVAGYTPRMRVGIHTGRPQRLAADWLGVDVNVAARVMERATKGGIMVSSSTLDLISQSELDAMGIVAKRARKPVFPHKSAGIPADLAIYRLKTHRELTASDDTAETQSQP
>NZ_AP022573.1|WP_085253804.1|448413_449481_-|DUF2236-domain-containing-protein
MTATGTYGTPSEDPLGPDSLTWKYFGDLRTGMMGIWIGAIQNMYPELGAGVEEHSILLREPLQRVARSVYPIMGVVYDGDRAAETGRQIKSYHHTIKGTDATGRRYHALNPETFYWAHATFFMLIIKVAEYFCGGLTEAEKRQLFDEHVRWYRMYGMSMRPVPESWEDFRKYWDRVCREELEINQATLDIFRIRIPKPSFVLMPTPLWDQLFRPLVAGQRWIAAGLFDPAVREKAGMRWTLGDEVLLRLFGKLVELAFLAVPDEIRLHPRALAAYRRAEGRAPVDAPLVEAPAFMAPPRDRRGLPMHYFPPRPRSALDPALQPARAIMERAGSIVHTTLSLAGLRPARGRGRNAA
>NZ_AP022573.1|WP_085253803.1|447610_448390_+|RNA-methyltransferase
MLTERSARVAAAVKLHRHVGRRRARQFLAEGPNLVEAASARGLVREVFVTELAAERQASLLATLRCPVHPVTERAAKALSDTVTPTGLVAVCDMAETRLQDVLAGSPRLIVVAVEISEPGNAGTLIRIADAMGAGAVILGGHSVDPYNGKCLRASTGSIFSIPVVTAPDAPAAVAAVRAAGLQVLATTVDGETRLDTADLAAPTAWVLGPEAHGLAAELADAADHRVRIPMSGGAESLNVAAAAAICLYQSAQALGILS
>NZ_AP022573.1|WP_085253802.1|447202_447598_+|50S-ribosomal-protein-L20
MARVKRAVNAQKKRRTVLKASKGYRGQRSRLYRKAKEQQLHSLNYAFRDRRARKGEFRKLWISRINAAARANDITYNRLIQGLKAAGVEVDRKNLADIAITDPAAFTALVEVARAALPEDVNAPSDSGEAA
>NZ_AP022573.1|WP_085253801.1|446928_447123_+|50S-ribosomal-protein-L35
MPKAKTHSGASKRFRRTGTGKIAREKANRRHLFEHKPTKRTRRLAGRTIVAANDTKRVKSLLNG
>NZ_AP022573.1|WP_163645076.1|462397_467215_+|PE-domain-containing-protein
MSFVFAVPDVVEIAAQDLAGIRSALDEVAQAVVAPTTGLVPAAGDEVSAAIASLFGNFGEEFQALNAQVGAFHNAFVNALGGGAAAYASAEVANSAAFLSGSGNLAADLGAALSGFGASLGASLSGGLSTSLGASLGPTIGTLLSAGIGGVAAQTGGFILSSIGGGLVATGNAITQAGLALENAGASLSALGGPLVAQANAALAALLNADFAANISAALNAGVNGSLAGLFQTGANLAGNLGANLNGALNALLSGNLALPALPPITFPALPPIALPNIGADINAALNALLSGNLALPGLPPITFPALPPIALPNIGADINAALNALLSGNLALPGLPPITFPALPPIALPNIGADINAALNALLSGNLALPGLPPITFPALPPIALPNLGNLGVELSAALNGISGSLSASLNGLGASLNAALNAALSGSLALPGLPPITFPALPPISLPDIGADINAALNAALSGSLALPGLPPITIPGLPAFTLPGLPPITLSLGALGTDLSGALNALLTGSLTLPGLPPFTFPGLPPLTLPTLPQLGADINAAINAALSGSLALPGLPPITLPALTLPSLGNLGVELSAALNGISGSLSASLNGLGASLNAALNAALSGSLALPGLPPITFPALPPIALPDIGVDINAALNALLSGNLALPGLPPITFPALPPIALPDIGADINAAINTLLSGSLALPGLPPITLPALPPISLPDIGADINAALNAVLTGNLALPGFPPITLPPITFPALPDLGSLGVELSAALNGISGSLSASLNGLGASLNAALNAALSGSLALPGLPPITFPALPPIALPDIGADINAALNALLTGNLALPGLPPITFPALPPLTLPDIGADINAALNALLSGNLALPGLPPITFPALPPISLPNIGADINAAINAVLTGNLALPGFPPITFPALPPLALPDLGSLGVELSAALNGISGSLSASLNGLGASLNAALNAALSGSLALPGLPPITFPALPPLTLPNIGADINAALNALLTGSVTIPGFPPITLPGLPSLTLSLGALGTDINAALNALLTGSLTIPGLPPITLPGLPSLTLSLGALGTDLNAAINAALSGSLALPGLPPITLPALTLPDLGNLGVELSAALNGISGSLSASLNGLGASLNAALNAALSGSLALPGLPPITFPALPPIALPDIGADINAAINTLLSGSLALPGLPPITLPALPPLTLPDIGADINAALNAVLTGNLALPGFPPITLPPITFPALPDLGSLGVELSAALNGISGSLSASLNGLGASLNAALNAALSGSLALPGLPPITFPALPPIALPDIGADINAALNALLTGNLALPGLPPITFPALPPIALPDIGADINAALNALLSGNLALPGLPPITLPPFALPNLGNLGVELSAALNGISGSLSASLNGLSASLNAMLGGSLNLGANLNGLIQTGATLAGNFVTGLGDLATNITAGLNTAIQTGANLAADFFAALPTLSLPNLGLTINAALSASLGGALNGLLNATGSLAGGLTGGLAGLVNAGETLGASLGAGLGGLAQTGGTLATIWVDTTQAVADALGTGLEASVGVAFPGLFQTGETLALGLEDAVGGLAQTTGGLTASLEAALTDLGASLQAAINASLGIGIAA
>NZ_AP022573.1|WP_085256893.1|467374_468418_+|N-acetyl-gamma-glutamyl-phosphate-reductase
MADETRVAVAGASGYAGGEILRLLLGHPRYGDGRITIGAVTAAASAGSTLAEHHPHLTPLAQRVFEPTELSVLAGHDVVFLALPHGHSAALADQLDDETLVIDCGADFRLTDAAAWERYYGSPYAGSWPYGLPELPAGRERLRGARRIAVPGCYPTAALLGLWPAMAEGLIEPAVTVVAVSGASGAGRTPKTDLLGSEVIGSARAYNIGGAHRHTPEIAQGLEMVTDRDVTVSFTPVLIPTSRGILATCTARTRSPLSQLRGAYEKAYHAEPFIHLMPEGQLPRTGAVIGSNAAHIAVAVDEAAETFVAIVAIDNLVKGTGGAAVQSMNLALGWPETEGLSVVGVAP
>NZ_AP022573.1|WP_085256892.1|468414_469629_+|bifunctional-glutamate-N-acetyltransferase/amino-acid-acetyltransferase-ArgJ
MTEVASAMRLVREQGVTAPAGFRAAGIAAGIKASGARDLSLVLNEGPDYAAAGVFTRNKVKAAPVLWTQQVLTTGELRAVILNSGGANACTGPGGFQDAHATAEAVAAALSDWGTETGAIEVAVCSTGLIGDRLPMDKVLAGVRQIVQDMAGGLSGGDEAAQAIMTTDTVPKQVALHHPGDWTVGGMAKGAGMLAPSLATMLCVLTTDAVADSGALDRALRHAAARTFDRLDIDGACSTNDTVLLLASGASGIAPAQADLDEAILRVCDDLCAQLQSDAEGVTKRVAVTVTGAASEDDALAAARVVARDSLVKTAVFGSDPNWGRVLAAVGMAPVTLDPNRIAVSFNGFPVCIDGAGAPGARDVDLSAADVDITVDLGVGAASATIRTTDLSHGYVEENSAYSS
>NZ_AP022573.1|WP_085256891.1|469625_470513_+|acetylglutamate-kinase
MTRATEDLPTQIKAEVLAEALPWLKQLHGKIVVVKYGGNAMTDETLKHAFAADMAFLRNCGIHPVVVHGGGPQISAMLRRLGIEGDFKGGFRVTTPEVLDVARMVLFGHVGRELVNLINAHGPYAVGITGEDAQLFTAVRRSVIVDGVATDIGLVGDVELVNTAAVLDLIAAGRIPVVSTLAPDAEGVVYNINADTAAAALAEALRAEKLLMLTDVEGLYTSWPNTDSLVSEIDTATLSQLLPTLEAGMIPKVEACLRAVTGGVPSAHVIDGRVKHCVLVELFTHAGTGTKVVSA
>NZ_AP022573.1|WP_085256890.1|470509_471697_+|acetylornithine-transaminase
MTATEDLQRRWEAVMMNNYGTPPVALASGEGALVTDVDGKTYLDLLAGIAVNVLGHRHPAVIEAVAHQMATLGHTSNLYATEPGIALAEELVALLAADTPTRVFFCNSGAEANEAAFKLSRLTGRTKLVAAQGAFHGRTMGSLALTGQPAKRAPFEPLPGDVTFVPYGDTDALAAAVGDDTAAVFLEPIMGEGGVVVPPEGYLAAAREVTTRHGALLVLDEVQTGMGRTGAFFAHQHDGITPDVVTLAKGLGGGLPIGACLATGPAADLLTPGSHGSTFGGNPICTAAALAVLRTIAAEDLVRHAEVLGKSVRHSIEALNHPLIDHVRGRGLLWGVVLSAPRAKEADAAAREAGFLINAAAPDVIRLAPPLIVTEAQIEGFADALPGILGKAADA
>NZ_AP022573.1|WP_085256889.1|471689_472616_+|ornithine-carbamoyltransferase
MPRHLLRDDDLSPDEQAEILQLAAELKKDPFSARPLEGPRGVAVLFDKNSTRTRFSFELGIAQLGGHAVVVDARSTQLGRDETLEDTARVLSRYVDAIVWRTFGQDRLQAMAKTATVPVVNALSDEFHPCQVLADLQTLTERKGSLAGLRMSYLGDGANNMAHSLMLGGVTAGIHVTVAAPTGFAPARALVAAAERRGETTGGSVTLTADPDAAARGADVLVTDTWTSMGQEGDGLDRVKPFRPFQVNERLLGLADPEVVVLHCLPAHRGEEITDEVMDGPASAVWDEAENRLHAQKALLAWLLERRR
>NZ_AP022573.1|WP_085256888.1|472612_473107_+|arginine-repressor
MTRAKTTHDITRAGRQDRIVAILSSASISSQSELAARLAGEGIDVTQATLSRDLEELGAVKLRGADGGVGVYVVPEDGSPVRGVSGGTARLSRLLGELLVSADASANLAVLRTPPGGANYLASAIDRAALPYVVGTIAGDDTVFVAARDPMTGAELARTLESLT
>NZ_AP022573.1|WP_085256887.1|473122_474319_+|argininosuccinate-synthase
MSERVILAYSGGLDTSVAISWIGKETGREVVAVAIDLGQGGEDMEVVRQRALDCGAVEAVVVDARDEFAEGYCLPTVQNNALYMDRYPLVSAISRPLIAKHLVAAAREHGGGIVAHGCTGKGNDQVRFEVGFASLAPDLEVLAPVRDYAWTREKAIAFAEENGIPINVTKRSPFSIDQNVWGRAVETGFLEHLWNAPTKDIYAYTEDPTVNWSTPDEVIIGFERGVPVSIDGRGVSVLQAIEELNHRAGAQGVGRLDVVEDRLVGIKSREIYEAPGAMVLITAHTELEHVTLERELGRFKRHTDQRWAELVYDGLWYSPLKVALESFVATTQEHVSGEIRLVLHGGHIAVNGRRSAESLYDFNLATYDEGDNFDQSAAKGFVYVHGLSSKIAARRDHQ
>NZ_AP022573.1|WP_085256886.1|474422_475832_+|argininosuccinate-lyase
MSTREGSLWGGRFADGPSDALAALSKSTHFDWVLAPYDITASRAHTVILHRAGLLTEEQRDGLLAGLDSLAADIADGSFGPLPSDEDVHAALERGLIDRVGTDLGGRLRAGRSRNDQIATLFRMWLRDAVRRVAAGALDVVGALAAQAAAHPAAIMPGKTHLQSAQPVLLAHHLLAHAHPLLRDVDRILDFDKRAAVSPYGSGALAGSSLGLDPDAIAAELGFAAAADNSIDATAARDFAAEAAFVFAMIAVDLSRLAEDIILWSSTEFGYVRLHDSWSTGSSIMPQKKNPDIAELARGKAGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAMAGLVASLTFDTERMAALAPAGYTLATDIAEWLVRQGVPFRSAHEAAGAAVRTAEGRGVGLDELTDDELAAISPALTPRVREVLTIEGSVSSRDARGGTAPQRVAEQLEGVLARGEALRVRLT
>NZ_AP022573.1|WP_085256885.1|475934_476996_+|type-III-polyketide-synthase
MSVVAGVFGALPPYRYSQRELTDFFISIPDFEGYEDIVRQLHASAKVNSRHLVLPLERYPALTDFGMANRIFIDNAVDLGCEALSGALDEAGLRPQDLDVLITTTVTGLAVPSLDARIAGRLGLRDDVRRVPLFGLGCVAGAAGVARLHDYLRGAPDGAAALVSVELCSLTYPGYKPSLAGLVGSALFADGAGAVVAVGDRRAEEVDARGPGIVDSRSHLYPDSLRTMGYDVGATGFELVLSKDVAAVVEQYLHDDVTGFLAAHGLSTTDIGAWVSHPGGPKVIEAINASLDLSPQALELTWRSLGEIGNLSSASVLHVLRDTIAKKAPTDSPGLMIAMGPGFCSELVLLRWP

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Crispr_ID: NZ_AP022573_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022573_2

1046279-1046358

Orphan

Consensus_repeat	Method
CTCGCCGATGAGGCCGCCGACCGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022573_2

>merge|NZ_AP022573|2|1046279-1046358|CRISPRCasFinder
CTCGCCGATGAGGCCGCCGACCGGGCCGCCTACCTGGCCCTCAAGGCGCGCCAGCGCGGCGAAGAGCTCGCCGACGAGGC

>NZ_AP022573|2|2|1046279-1046358|CRISPRCasFinder
CTCGCCGATGAGGCCGCCGACCGGGC	CGCCTACCTGGCCCTCAAGGCGCGCCAG
CGCGGCGAAGAGCTCGCCGACGAGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022573.1\|WP_085257401.1\|1047083_1049087_-\|phosphotransferase	unknown	unknown	gnl\|CDD\|367273
NZ_AP022573.1\|WP_085257364.1\|1068039_1068843_-\|polyprenol-monophosphomannose-synthase	unknown	unknown	gnl\|CDD\|133062
NZ_AP022573.1\|WP_085257348.1\|1036895_1037732_-\|DUF3097-domain-containing-protein	unknown	unknown	gnl\|CDD\|378628
NZ_AP022573.1\|WP_085257402.1\|1046574_1047060_-\|gluconokinase	unknown	unknown	gnl\|CDD\|225804
NZ_AP022573.1\|WP_085257361.1\|1051680_1054302_-\|sugar-epimerase-family-protein	unknown	unknown	gnl\|CDD\|235630
NZ_AP022573.1\|WP_007170328.1\|1067685_1068021_+\|RNA-polymerase-binding-protein-RbpA	unknown	unknown	gnl\|CDD\|379162
NZ_AP022573.1\|WP_085257360.1\|1050746_1051427_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|184923
NZ_AP022573.1\|WP_085257403.1\|1070925_1072458_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|238625
NZ_AP022573.1\|WP_163645197.1\|1067170_1067368_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022573.1\|WP_085257357.1\|1044850_1045411_-\|pyrazinamidase-PncA	unknown	unknown	gnl\|CDD\|238493
NZ_AP022573.1\|WP_085257354.1\|1042089_1043412_-\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270303
NZ_AP022573.1\|WP_085257350.1\|1038233_1039235_-\|patatin-like-phospholipase-family-protein	unknown	unknown	gnl\|CDD\|132846
NZ_AP022573.1\|WP_085257352.1\|1040304_1041147_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_AP022573.1\|WP_085257359.1\|1049104_1050610_-\|carboxylesterase/lipase-family-protein	unknown	unknown	gnl\|CDD\|225181
NZ_AP022573.1\|WP_085257353.1\|1041133_1042093_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_AP022573.1\|WP_085257355.1\|1043698_1044049_+\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|379266
NZ_AP022573.1\|WP_085257362.1\|1054323_1066830_-\|type-I-polyketide-synthase	unknown	unknown	gnl\|CDD\|225858
NZ_AP022573.1\|WP_085257349.1\|1037949_1038237_+\|DUF3349-domain-containing-protein	unknown	unknown	gnl\|CDD\|371747
NZ_AP022573.1\|WP_085257351.1\|1039231_1040302_-\|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC	unknown	unknown	gnl\|CDD\|236947
NZ_AP022573.1\|WP_085257356.1\|1044053_1044851_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|366932

Protein	Function_ID	Function_description	E-value
NZ_AP022573.1\|WP_085257401.1\|1047083_1049087_-\|phosphotransferase	gnl\|CDD\|367273	pfam02958, EcKinase, Ecdysteroid kinase. This family includes ecdysteroid 22-kinase, an enzyme responsible for the phosphorylation of ecdysteroids (insect growth and moulting hormones) at C-22, to form physiologically inactive ecdysteroid 22-phosphates.	7.58012e-20
NZ_AP022573.1\|WP_085257364.1\|1068039_1068843_-\|polyprenol-monophosphomannose-synthase	gnl\|CDD\|133062	cd06442, DPM1_like, DPM1_like represents putative enzymes similar to eukaryotic DPM1. Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.	4.62485e-101
NZ_AP022573.1\|WP_085257348.1\|1036895_1037732_-\|DUF3097-domain-containing-protein	gnl\|CDD\|378628	pfam11296, DUF3097, Protein of unknown function (DUF3097). This family of proteins with unknown function appears to be restricted to Actinobacteria.	2.1577e-150
NZ_AP022573.1\|WP_085257402.1\|1046574_1047060_-\|gluconokinase	gnl\|CDD\|225804	COG3265, GntK, Gluconate kinase [Carbohydrate transport and metabolism].	1.30645e-70
NZ_AP022573.1\|WP_085257361.1\|1051680_1054302_-\|sugar-epimerase-family-protein	gnl\|CDD\|235630	PRK05865, PRK05865, sugar epimerase family protein.	0
NZ_AP022573.1\|WP_007170328.1\|1067685_1068021_+\|RNA-polymerase-binding-protein-RbpA	gnl\|CDD\|379162	pfam13397, RbpA, RNA polymerase-binding protein. RbpA is a family bacterial RNA polymerase-binding proteins. RbpA acts as a transcription factor by binding to the sigma subunit of RNA polymerase.	4.96406e-50
NZ_AP022573.1\|WP_085257360.1\|1050746_1051427_+\|hypothetical-protein	gnl\|CDD\|184923	PRK14959, PRK14959, DNA polymerase III subunits gamma and tau; Provisional.	0.00642769
NZ_AP022573.1\|WP_085257403.1\|1070925_1072458_-\|amidohydrolase	gnl\|CDD\|238625	cd01300, YtcJ_like, YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling.	8.96459e-110
NZ_AP022573.1\|WP_085257357.1\|1044850_1045411_-\|pyrazinamidase-PncA	gnl\|CDD\|238493	cd01011, nicotinamidase, Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).	1.65091e-70
NZ_AP022573.1\|WP_085257354.1\|1042089_1043412_-\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.19181e-70
NZ_AP022573.1\|WP_085257350.1\|1038233_1039235_-\|patatin-like-phospholipase-family-protein	gnl\|CDD\|132846	cd07207, Pat_ExoU_VipD_like, ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2. ExoU, a 74-kDa enzyme, is a potent virulence factor of Pseudomonas aeruginosa. One of the pathogenic mechanisms of P. aeruginosa is to induce cytotoxicity by the injection of effector proteins (e.g. ExoU) using the type III secretion (T3S) system. ExoU is homologus to patatin and also has the conserved catalytic residues of mammalian calcium-independent (iPLA2) and cytosolic (cPLA2) PLA2. In vitro, ExoU cytotoxity is blocked by the inhibitor of cytosolic and Ca2-independent phospholipase A2 (cPLA2 and iPLA2) enzymes, suggesting that phospholipase A2 inhibitors may represent a novel mode of treatment for acute P. aeruginosa infections. ExoU requires eukaryotic superoxide dismutase as a cofactor and cleaves phosphatidylcholine and phosphatidylethanolamine in vitro. VipD, a 69-kDa cytosolic protein, belongs to the members of Legionella pneumophila family and is homologus to ExoU from Pseudomonas. Even though VipD shows high sequence similarity with several functional regions of ExoU (e.g. oxyanion hole, active site serine, active site aspartate), it has been shown to have no phospholipase activity. This family includes ExoU from Pseudomonas aeruginosa and VipD of Legionella pneumophila.	1.26902e-63
NZ_AP022573.1\|WP_085257352.1\|1040304_1041147_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	3.31542e-91
NZ_AP022573.1\|WP_085257359.1\|1049104_1050610_-\|carboxylesterase/lipase-family-protein	gnl\|CDD\|225181	COG2272, PnbA, Carboxylesterase type B [Lipid metabolism].	0
NZ_AP022573.1\|WP_085257353.1\|1041133_1042093_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	7.56422e-96
NZ_AP022573.1\|WP_085257355.1\|1043698_1044049_+\|DoxX-family-protein	gnl\|CDD\|379266	pfam13564, DoxX_2, DoxX-like family. This family of uncharacterized proteins are related to DoxX pfam07681.	4.39763e-09
NZ_AP022573.1\|WP_085257362.1\|1054323_1066830_-\|type-I-polyketide-synthase	gnl\|CDD\|225858	COG3321, COG3321, Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	0
NZ_AP022573.1\|WP_085257349.1\|1037949_1038237_+\|DUF3349-domain-containing-protein	gnl\|CDD\|371747	pfam11829, DUF3349, Protein of unknown function (DUF3349). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 99 to 124 amino acids in length.	2.75099e-22
NZ_AP022573.1\|WP_085257351.1\|1039231_1040302_-\|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC	gnl\|CDD\|236947	PRK11650, ugpC, sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC.	0
NZ_AP022573.1\|WP_085257356.1\|1044053_1044851_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|366932	pfam02136, NTF2, Nuclear transport factor 2 (NTF2) domain. This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.	8.72488e-14

>NZ_AP022573.1|WP_085257357.1|1044850_1045411_-|pyrazinamidase-PncA
MRALIIVDVQNDFCPGGSLPVAGGAAVASAISDYLATGPSYAHVVATQDSHVDPGDHFSERPDYSSSWPPHCLAGTAGAGFHPALDTRKIEAVFRKGAHEAAYSGFEGVDEDGTPLLDWLRRRGVDEVDVVGLATDFCVRRTAEDAARAGLATRVLMNLTAPVAADSAARTADELRAAGVELVGGP
>NZ_AP022573.1|WP_085257356.1|1044053_1044851_-|nuclear-transport-factor-2-family-protein
MAIPEPESLLAVVDRSPRAAAAHDRTGWVSLFTDDGRVEDPVGSRPHVGHAAIGRFFDTFIGPRDITFHRDLDIVAGTAVLRDLELEVAMGPAVTMHIPAFLRYDLRKVDGQWRIARLRAYWELPAMMRQFLRSGTRAWSPALQLSRGLLGNQGPRGAAGFMAGFRRPGTRHQKRVAVFLAAASGGDQTAAARALSQTAAITLGDGEPLGVAELVERLAGSRQTKTTSAGPTVVVSVDSGARRGIVFADVARPGATIDRLRYFPA
>NZ_AP022573.1|WP_085257355.1|1043698_1044049_+|DoxX-family-protein
MTSVFVLITLTTAVVTAAIAVADLIPARFVLANSAEVGVPRSWLPGLAALKLAGAAGLVAGLLGPRALGIAAATGLVLFFVGAVITHLRARVLYNLAFPGAYLALSAATLALMVAR
>NZ_AP022573.1|WP_085257354.1|1042089_1043412_-|sugar-ABC-transporter-substrate-binding-protein
MLDKPFARRSLLRGAGALTAMSIASWAAGCAPNDDALTFFFAANPDELDARMRIVDEFQRRHPDIKVRAVLSAPGVMQQLSTFCAGGKCPDVLMAWDLTYAELADRGVLLDLNTILARDAAFARELQSDSIVPLYDSFNYNGGQYALPEQWSGNYLFYNRRLFAEAGLPAPPTSWEHPWSFGEFLETARASTKRGGSGRATQWGFVNMWYSYYSAGLFAMNNGVPWSTPLKNPAHFNFDDDAFVEAVQFYADLANKHGVAPNASEVQSMSTPDLFASGKAAMALGGHWRYQTFIRADGLDFDVTSLPVGPRRQGQAARSNIGSTGLAISAGSPRREQAWEFVKFATGPVGQALIAESSLFVPVLRSALDSAGFAKAHRRLGNVAVLTQGPAHSDGLPVTPAWEKVVALMDRSFGPVLRGSRPATSLRALSPAVDEVLHAS
>NZ_AP022573.1|WP_085257353.1|1041133_1042093_-|sugar-ABC-transporter-permease
MTSVDTPAPAGPVTRQSANSSRPARRRARAGRLFVAPNLAAVVVFMLFPLGFSLYMSFQNWDVFRPPKYVGLKNFGELFTSDPLFLIAIRNTVVFTVGTVVPTLLISLVVAGVLNRKVRGIGIFRTIVFLPLAISSVVMAVVWQFVFNTDNGLLNIMLGWIGIGPIPWLVDPKWAMVSLCMVSVWRSVPFATVILLAAMQGVPETLYEAARIDGAGEIRQFAFITVPLIRGAMSFVVVISIIHAFQAFDMVYVLNGPNGGPESATYVLGIMLFQHAFSFLEFGYASALAWVMFAILLVLTVLQLRLTRQRSMEASRGLG
>NZ_AP022573.1|WP_085257352.1|1040304_1041147_-|carbohydrate-ABC-transporter-permease
MVSGERVFKRNVFRALLVYTALIAIAWCWLFPIAWAVSGSLKNEGEVTEPRLLPAHPRWSNYTEAFTLMPFWRMFFNTVLYAGCVTAGQVFFCSLAGYAFARLQFRGRDTLFVLYLGTLMVPLTVTVIPQFILMRTLGWVDTPWAMIVPGLFGSAFGTYLMRQFFRTLPTDLEEAAILDGCSPWQIYWRILLPHARPAVTVLAVLTWVNVWNDFLWPLLMIQRNSLATLTLGLVRLRGEYVARWPVIMATSMLIMVPLVVIYAVAQRSFVRGIAVTGMNG
>NZ_AP022573.1|WP_085257351.1|1039231_1040302_-|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC
MASVSFERATRRYPGTDRPALEGLDLFVGDGEFVVLVGPSGCGKTTSLRMVAGLETLDSGRIRIGDRDVTDIDPKDRDVAMVFQNYALYPHMTVAQNMGFALKIAKIPKGEIRERVLDAAKLLDLQPYLERKPKDLSGGQRQRVAMGRAIVRRPQVFLMDEPLSNLDAKLRVQTRNQIAALQRRLETTTVYVTHDQVEAMTMGDRVAVLCDGVLQQFAPPRELYRNPGNVFVAGFIGSPAMNLFTLPIVDSSVSLGDWVIPLPRGIADSAPEVVVGVRPEHFELGSRGVEMEVDVVEELGADAYLYGRITGSGKVIDQPVVARADGRHPPEKGTRVRLHPEPGHLHFFGPDGCRVS
>NZ_AP022573.1|WP_085257350.1|1038233_1039235_-|patatin-like-phospholipase-family-protein
MTAHVSAGRVDLVCEGGGVRGIGLVGAVDALAEAGCRFPRVAGTSAGATVAALVAALQAAGEPMTRLGEVMRSIDYRKFLDRSLIGRVPLIGGGLSLLVSDGVYRGDYLERLLAGLLAELGVRTFGDLRTGEEPDQFAWSLVVTASDLSRRRLVRIPWDLPSYGVDPDDFPVARAVHASAAIPYVFEPVRVGGATWVDGGLLSDFPVELFDRPDAQPRWPTFGIRLSARPGIPPTHPVHGPVSLGIAAIETLLSNQDNAYIDDPCTVRRTIFVPAEEVSPIDFDITAQQRDALYQRGLQAGQEFLATWDYPAFLAACGGPVKPSGDASKERVP
>NZ_AP022573.1|WP_085257349.1|1037949_1038237_+|DUF3349-domain-containing-protein
MDLTQWVSSIVAFVRAGYPSGMPMTGHVPAAALSRRRVSTDEIASLTDELAGHRPWPVSATDVGVAITRITDAMPSPEDIARIQRRLDCRKAPTA
>NZ_AP022573.1|WP_085257348.1|1036895_1037732_-|DUF3097-domain-containing-protein
MADRYGTDVLAAGRRKPRSTEHPVELGMVVEDAQTGYVGAVVRVEYGRIDLEDRHGRTRGFPLGPGYLLDGRPVILTAPRRPAPADAGRTASGSVAVPGTRARVARASRIYVEGRHDAELIAQVWGEDLRIEGVVVEHLGGVDDLVGIVEEFAPGPGRRLGVLVDHLVAGSKEARIADAVRRGPGGAHTLVVGHPYVDIWQAVKAQRVGLTVWPDVPRHIEWKHGACRALGLPHGGQADIARAWRHIRARVRDWNDLEPALISRVEELIDFVTEPTAP
>NZ_AP022573.1|WP_085257402.1|1046574_1047060_-|gluconokinase
MGVSGSGKSTVGLALARRLRVPFVDAESLHPPDNIAKMAAGQPLDDDDRYPWLEKVGQWLADHRDGGVVSCSALKRKYRDQLRAHCPRTEFLHLSGSAEVIGRRLAVRIGHFMPPALLRSQLDVLEPLGTDEAGVTVDVDRDVDEIVDSFVAGAAPRRPQN
>NZ_AP022573.1|WP_085257401.1|1047083_1049087_-|phosphotransferase
MHAETKHVVERPADLTAAWLTAAVGAGPIADFSVERIGTGQMSECYRVRLTYTDAGAPGPSPVVLKVAATDPVSRQTGLALGLYEREVRFYSGVAPRLGGPIAPCYHAAVDTSTGAFDLLLGDAGPALVGDEIAGATSEQAHLAVVELGRLQGPLLGDAVLAEAAWLNRDSPLSQAMIAPLYAGFIDRYGDQIAPEHRVVCERLVAAFDGYLAQEAAPGRVRGLVHGDYRLDNMLFGAAGADRALTVVDWQTVSWGPALTDLSYFLGSALTTPDRRLHYDALLRAYHQALGQGAPLSLADVAEGVRRQSFFGVMMAIVSSILVERTERGDRMFMTMLQRHCDHVLDTDALATLPAAVAPEPLRPTEDDELTHTPTAEPLWSESWYADFADAAQGLGGWFRIGLIANQRKALIHALLCGPDLPTIAVDAQVPLPGDPWAVHADTFDIEHSASAPLQAYRVDVRARAQAYSDPSALLRGEPGAPVEMAMNLVWTTDGAPYKYRLTTRYEIPCTVSGAVTIGDTRYEIAAVPGQRDHSWGVRDWWSMDWIWTALHLDDGTHLHGVNIRIPRTPSFSVGYAQRDGDVTELHTVDSREAFGGNGLPRDATVTLEPAGIAAELHPAGHAPVLLTADDGRISQFPRAWATITTADGRRGVGWVEWNRNPADRTG
>NZ_AP022573.1|WP_085257359.1|1049104_1050610_-|carboxylesterase/lipase-family-protein
MHERTVRARTTTGTVEGFTRDGVNRWRSIPYARPPVGRLRFRAPQPASPWSGVRHCHGFGNCAPQQRRYTMLGVGRYQPMGEDCLTLNVVTPERAGGEPLPVMVFIHGGGYILGSSATPLYDGAALARRGCVYVSVNYRLGALGCLDLSSLSTPEHPIDSNLYLRDLVMALQWVRDNIAEFGGDPGRVTIFGESAGAHITATLLAVPAAEGLFARAISESPASGMVRSRETAEEFADRFARLLGATGRDAAQALMQASPERLVETQHRLIDQGMENRLGAFPIGPVFGDDVVPVDPVEAMRTGRAHRVPLIVGTNAEEGRLFTRFLKMLPTNQTMIEELLADTDPAARERITAAYPDYPAPSACIQLGGDFAFSSAAWQIAEAHGTHAPTYLYRYDYAPRTLRWSGLGATHATELLAVFDVYRTRFGALLTAAADRRAALKVSNQVQRRWRSFSHSGVPGDDWPAYTVEDRAVMVFDRKCRVEFDPHPHRRIAWDGFSLAQ
>NZ_AP022573.1|WP_085257360.1|1050746_1051427_+|hypothetical-protein
MRIAVLMAASLLVAGCSHPGGGSSGQTTGPSGSAPPTTTTPSTGKPAAPSTAPAAGASMPDVIAWIEAGRPADPGRYHSATRDGVTTPLGDDVAFTAKAAQASCMTDARHTGGALLCLVSLVSPPPRPETAYGDWKGGWVDFDGTNLQVGASRGDPGPFVNGDGAELATGDTLSIGDYRCRAGDAGLFCVNYAHQSAVRFAAVGIEPFGCLRSVPPPDGVGIAFGC
>NZ_AP022573.1|WP_085257361.1|1051680_1054302_-|sugar-epimerase-family-protein
MRIAITGAGGVLGRGLAARLLGQGHEVVGIARHRPDSWSSAAEFVTADIRDSGAVKRCIAGADVVAHCAWATSPGPYDRISREVNIDGTLNVLAAMADSGTSRIVFPSSAHVYGGGGAARAEGDATTPGSADGILKARVEQLVSTAEVDSISVRCAPVVGRGVDNWVLRALALPAFPDGPVDRGLQLIHVDDALRLLQRAILDRQIPTTTVNLAAPGMTAFRRVAAALGRPVIPLAGPLAAQARRRFAAELELVRGAPLMNTARLRDEWGFAPAWSADECVEDLALAVRGRVTVGRRVVSLPWRLANIQELPAVDAPADDGVRPRLAGPEGLNGEFDTPIDPRFPTYLATNLSEALPGPFSPSSASVTVRGLRAGGVGIAARLRPGGIIQREIAMRTVAVFAHRLYGAITSAHFMAETVPFAKPATIVSNSGFFGPSMASLPIFGDERPPSESGRLRKQLRTVRNIGVFGVNLVGLSAGSPADTRDFVADVDRLERLAGGDLTRLDERRLLSLVLLARDHVVHSWVLASGSFMLCAAFNVLLRGLCGKDTAPAAGPELVSARSVEAMQRLVAAAQRDPKVSRLLAEPGHHLDRLAADAPEFHAAVLDELALIGHRGPAELEMLSTSYADDPELLIRMVTRAMSAPPAPQPWHARIPLRAKPVAFLAARQLRDREVRRDKMVRANWVLRALLREYGRRLVDAGTFDTADDVFYLLVDELDALPPDVKDLVARRRAEQRRLAGVVPPTVFSGSWQPSVTSTPALSSGDTLRGVGVCGGRVRGRVRIVRPETIDDLQPGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFGFPCVVDAQGATRRLPAGALVEVDGSTGEIRVLEPAS
>NZ_AP022573.1|WP_085257362.1|1054323_1066830_-|type-I-polyketide-synthase
MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGIDSPEGLWQMVADGRDVMTEFPTDRGWDLAGLFDPDPDARHKSYVRTGGFVDGVADFDPGFFGIAPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVQGYGMLAEEIEGYRLTGMTSSVASGRVSYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFSRHRGLAPDGRCKAYAGAADGVGWSEGGAVLVVERLSDARRLGHPVLAVVRGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSPGDVDVVEGHGTGTTLGDPIEAQALLATYGQGRTEPLWLGSIKSNMGHTQAAAGVAGIIKMVLAMRHELLPATLHVDEPSPHVDWSAGAVSLLSEARVWPADGRVRRAGVSSFGISGTNAHVIVEAAPESARPEVGSVPVVVPWVVSAKSASALGAQASRLAEHVRGHGGLGAVDVAWSLAGRSAFEHRAVVVGGERDRLLAGLDELAADSPVSVIRGTATPAGKTVFVFPGQGSQWPGMGVELLDTAPAFAQQIRACEEAFAEFVDWSLTDVLRGAPGAPGLERVDVVQPVLFAVMVALAELWKSVGVRPDAVIGHSQGEIAAAYVSGALSLRDATKVVILRSKLLTALAGPGGMASIACGAERARELLAPFGDRLAIAAVNGPSAVVISGEVAALDQLIGSCADHGLRTRRIDVDYASHSAEVEAIRHELTEALAGIEPLASRTAFFSTVTGSRVDTTALDADYWYRNIRQTVLLDQAVRSAVEHGYRTFIESSPHPALIAGIEDTVNDCTAGPAEARVVPTLGRDEGGLERFLVSAATAFVAGVGVDWRGVLDGGRFVELPTYAFERRRFWIAGDGVGADAAGLGLAAGEHPLLGAVVDLPASGGVVLTGRLSPTGQGWLADHAVSGVTVFPGAGFVELAIRAGDEVGCPVVDELTLQAPLLLPSSGAVAVQVVVGAPADAEGGRRSVSIFSRADSDAASAWVCHAEGALSPGSVEPAADLSAWPPAGAVAVDAADGYERLAAGGYGYGPAFRGLTAMWVRGDEVFAEAKLPDAAGGAGGFGIHPALLDAALHAVVMANQGAAEVALPFAWQGVSLHAAGASAVRARIAPTGPTSVSIELADGLGLPVLSVSSMAARPVTEQQLRAAVSGTGPDRLFEVIWSPASAPASSSAAAGDSQPYEVFESLAGQTDPVADAHDRTRRALAAVQSWLTERDSGVLVVATRGAMALAGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPVDDSAVSAVLAVGEPQAVLRGHTVHTPRVRASRPAGGVLTPPADGPWRLGIGSAGTFENLRLEPVPNAGAPLEPGQVRVAMRAIAANFRDIMITLGMFTHDALIGGEGAGVVVEVGPGVTEFAVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLAAVKPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASRGKWDTLRAMGFDEDHISDSRSLEFEEKFRTVTGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVVAQEYPGVRYRAFDLFEPGRPRMHQYMLELAELFDAGILRPLPVTTFDVRRAPAALRYLSQARHTGKIVLTMPDAWAAGTVLVTGGTGMAGSALARHVVNHHGARNVLLLSRRGPDAPDAADLAAELGRAGAQVRVVACDAADRQALADVIAAIDGQHPLSAVVHAAGVLDDGVVTSLTPERVDAVLRAKVDAAWNLHELTRDLDVSAFVMFSSMAGLMGAPGQANYAAANTFLDGLAQHRRANGLPAVSLGWGLWDQASAMTGGLDAADRARLGRDGVLALSSDEALELFDTAVMLEEPYLAAARIDLTALRAHAVRVPPMFTELVNAPARRQVDDSLVAAKSKSALAQRLHGLPEAEQHAVLLDLVRSHIATVLGNVDPEAIDPDKAFQELGFDSLTAVEMRNRLKTATGLSLSPTLIFDYPTPGALARYMRAELAGVPQEVKHVPAVRAAGDDPIAIVGMSCRYPGGVNSPDDLWAMLVDGRDVLSEFPGDRGWDLAGLFNPDPDVPGACYTRTGGFVDGVADFDPGFFGVGPSEALAMDPQQRMFLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVSYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGVTINATPDIFVEFSRWRGLSPDGRCKAFAGAADGTGFSEGGGMLVVERLSDARRLGHPVLAVVRGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSPGDVDVVEGHGTGTTLGDPIEAQALLATYGQGRTEPLWLGSIKSNMGHTQAAAGVAGIIKMVLAMRHELLPATLHVDEPSPHVDWSAGAVSLLSEARVWPADGRVRRAGVSSFGISGTNAHVIVEAAPESARPEVGSVPVVVPWVVSAKSASALGAQASRLAEHVRGHGGLGAVDVAWSLAGRSAFEHRAVVVGGERDRLLAGLDELAADSPVSVIRGTATPAGKTVFVFPGQGSQTLGMGMGLHAAYPVFAEAFNTVVAELDRHLLRPLREVMWGHDEDLLNTTEFAQPALFAVEVALFRLLESWGVRPDFVLGHSVGELSAAHVAGVLSLENAAVLVAARGRFMQALPPGGAMVAVQATEEEVRPLLDASEQLGIAAINGPASVVISGAADDVAAVAERLRADGRRVHRLAVSHAFHSPLMEPMIDEFASVAAGLAVAPPSIPIVSNVTGQLAADDFASVAYWKRHIREAVRFADSIRFVHNAGAHRFVEVGPSSGLTASIEELLPDTPVTAMSALRKDRPEPSTLTDAVARGFVTGMNVDWRAAIGVGNFVELPTYAFERRRFWLSSDGAAADAAGLGLGASEHALLGAVVELPATGGVVLTGRLSPSAQGWLNDHAVGGIVLFPGAGFVELVIRAGDEVGCGIVDELNLAAPLALPAGGSVAVQVVVGGPEESGSRAVSVFSRAEIGSGWVLHAEGVLSPGSVEPGADLSAWPPVGAVPVDVGDGYERLAARGYGYGPAFRGLTSMWRRGDEVFAEVALPADAGVSTAGFGVHPAMLDAALHAVILTAESGEFAEGSILVPFSWQRASLHAAGASAVRARIAPTGRSSVSIELADGLGLPVLSVASMVARPVSDQQLLAAVSNSGPDRLFEVVWSAQPSAAVQPVAVTRWDAAGFDAGADQGEAGPRAYLFESAPARGDVVTEVYAATRAVLAVLQAWLADDRSGTLVVCTRGAVALPGKDVTDLAGAAVWGLVRSAQTEHPGRVVLVDSDAPLDEDEVAAVLAVGEPQAVLRGGTVHTARVHGSRGVNGLLVPPGEGAWRLGMSSHGTFENLRLERIPDADAPLAPGHVRVATSAIAANFRDVMIALGLYPDPDAIMGVEASGVVVETASEKSDFAVGDRVMGLFPDGTGTLAVTDERLLVKVPAGWSHTAAATTSVVFATAFYALRDLAGVRPAQRILVHAAAGGVGMAAVQLARHWGLEVFATASRGKWDTLRAMGFDEDHIADSRSLEFEEKFRAVTGGRGMDLVLDSLAGDFVDASLRLVAPGGVFLEMGKTDIRDADAVARDHPGVRYRAFDLFEAGPDRIRQMLAELAALFGDDVLRPLPVTTFDIRRAPAALRYLSQARHVGKVVMVMPDAWTDGTVLITGGTGMAGSALARHVVAHHGVRDLVLVSRSGPEAPGAAELVADLSEAGARVHVVACDAADREALAKVIADIGVQHPLSAVIHTAGALDDAVVTSLTPERMAVALRAKVDAAWNLHELTRDLDLSAFVMFSSMAGLVGSSGQGNYAAANSFLDALAAHRQAQGLPALSLGWGLWNQASAMTGGLATVDFARFARDGIVAMSSDEALQLLDTAMIVGEPFLLPAHIDFAALRVKFDGGTLPPMFVDLINAPTRRQVDDTLAAAKSKSALLQRLEGLPEDEQRAILLDLVRSNIATVLGSASPEAIDPDRAFQELGFDSLTAVEMRNRLKSATGLPLSPTLIFDYPNSAALAGYMHSELVGASEQAAPAAAAPGDADIQRVVGSIPIKRLRQAGVLELLLALAAESDGSENGNGHGPAAVSTQKDIADMDLDDLVNAALMNDDE
>NZ_AP022573.1|WP_163645197.1|1067170_1067368_-|hypothetical-protein
MPADAVVLSADDAADLSDRVYQVRCAADDVATALDEGAGPAELRELCDVLVRAARAADGWRRAGV
>NZ_AP022573.1|WP_007170328.1|1067685_1068021_+|RNA-polymerase-binding-protein-RbpA
MADRVLRGSRLGAVSYETDRNHDLAPRQIARYRTENGEEFEVPFADDAEIPGTWLCRNGMEGTLIEGDLPEPKKVKPPRTHWDMLLERRSVEELEELLKERLEIIRTRRRG
>NZ_AP022573.1|WP_085257364.1|1068039_1068843_-|polyprenol-monophosphomannose-synthase
MTSGKPAPRIPGGIPNQPSQRTLVIIPTYNERENLPVIHRRLKEACPNVHLLIVDDSSPDGTGEIADELAAADPGRTHVMHRTAKDGLGAAYLAGFAWGLSHDYSVLVEMDADGSHAPEQLHLLLDAVDAGADLAIGSRYVEGGNVRNWPWRRWALSWTANTYARLALGIGVHDITAGYRAYRREVLEAIGLDAVDSKGYCFQIDLTWRTVCNRFTIVEVPITFTERELGVSKMSGSNIREALAKVTRWGVEGRLNRVRAARAHDHA
>NZ_AP022573.1|WP_085257403.1|1070925_1072458_-|amidohydrolase
MAVRGDVVVWLGSDDVGRGQFPGAGVEDLQGAFVGPGFVDSHVHVSAMGLTLSGLDLRPARSRGECLRMLADHAAAHPDRPVWGHGWDESGWPENSPPTTADLDAALGDRPAYLTRVDVHSALASTALRRLAPDLPAAAGFSAEEPLAGDAHHLVRALARDLLTPEQLADARTAALHAAAASGIVAVHECAGPEIGGLEDWRRLRALDHGVEVVGYWGEAVTTPEQARALLDETGARGLAGDLFVDGALGSRTAWLHEPYADAPDRVGTCYLDPDAVEAHVRACTTAGVTAGFHVIGDAAVSAAVAAFERVVDDLGVGAVARCGHRLEHVEMVSAEQAAKLGAWGVIASVQPNFDALWGGADGMYARRLGAERGLRLNPLALLASQGVPLALGTDAPVTGHDPWASVRAAVNHRTPGSAVSARAAFAAATRGGWRAAGVRDGTAGTLVPGAPASYAVWDVGPLEVSAPLDGVQRWSTDPRSRVPALPPLGPTDALPRCLRTVHRGAVIYG

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Crispr_ID: NZ_AP022573_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022573_3

1782052-1782134

Orphan

Consensus_repeat	Method
ACGTTCGGGTCGAAGCCCACCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022573_3

>merge|NZ_AP022573|3|1782052-1782134|CRISPRCasFinder
ACGTTCGGGTCGAAGCCCACCGGCGCCGGCGGCGGCACGTCAGGTCCCGGCGGCGGCGGAACGTTCGGGTCGAAGCCCACGGG

>NZ_AP022573|3|3|1782052-1782134|CRISPRCasFinder
ACGTTCGGGTCGAAGCCCACCGG	CGCCGGCGGCGGCACGTCAGGTCCCGGCGGCGGCGGA
ACGTTCGGGTCGAAGCCCACGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022573.1\|WP_085258008.1\|1772260_1775140_-\|Rne/Rng-family-ribonuclease	unknown	unknown	gnl\|CDD\|273254
NZ_AP022573.1\|WP_085254965.1\|1791119_1791710_-\|ATP-dependent-CLP-protease-proteolytic-subunit-ClpP1	unknown	unknown	gnl\|CDD\|178955
NZ_AP022573.1\|WP_085257132.1\|1785163_1787140_-\|2-oxoacid:acceptor-oxidoreductase-subunit-alpha	unknown	unknown	gnl\|CDD\|274738
NZ_AP022573.1\|WP_085258013.1\|1780415_1781675_-\|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|225807
NZ_AP022573.1\|WP_085254964.1\|1791837_1793271_-\|trigger-factor	unknown	unknown	gnl\|CDD\|234956
NZ_AP022573.1\|WP_085258010.1\|1775885_1776272_-\|DUF4233-domain-containing-protein	unknown	unknown	gnl\|CDD\|379420
NZ_AP022573.1\|WP_085258006.1\|1771444_1771699_-\|50S-ribosomal-protein-L27	unknown	unknown	gnl\|CDD\|235464
NZ_AP022573.1\|WP_142280517.1\|1796526_1797015_-\|ribose-5-phosphate-isomerase	unknown	unknown	gnl\|CDD\|235509
NZ_AP022573.1\|WP_085254966.1\|1790478_1791123_-\|ATP-dependent-CLP-protease-proteolytic-subunit-ClpP2	unknown	unknown	gnl\|CDD\|237133
NZ_AP022573.1\|WP_085258012.1\|1777734_1780389_-\|valine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235582
NZ_AP022573.1\|WP_085258005.1\|1769927_1771382_-\|GTPase-ObgE	unknown	unknown	gnl\|CDD\|237045
NZ_AP022573.1\|WP_085258009.1\|1775445_1775856_-\|nucleoside-diphosphate-kinase	unknown	unknown	gnl\|CDD\|179085
NZ_AP022573.1\|WP_085258007.1\|1771713_1772025_-\|50S-ribosomal-protein-L21	unknown	unknown	gnl\|CDD\|235510
NZ_AP022573.1\|WP_085254960.1\|1795722_1796523_-\|Fpg/Nei-family-DNA-glycosylase	unknown	unknown	gnl\|CDD\|223344
NZ_AP022573.1\|WP_085257131.1\|1787541_1788822_-\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpX	unknown	unknown	gnl\|CDD\|235422
NZ_AP022573.1\|WP_085257134.1\|1783437_1784046_-\|molybdenum-cofactor-guanylyltransferase	unknown	unknown	gnl\|CDD\|234798
NZ_AP022573.1\|WP_085254963.1\|1793649_1794858_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_AP022573.1\|WP_085258011.1\|1776268_1777738_-\|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	unknown	unknown	gnl\|CDD\|223362
NZ_AP022573.1\|WP_085258004.1\|1768818_1769931_-\|glutamate-5-kinase	unknown	unknown	gnl\|CDD\|235460
NZ_AP022573.1\|WP_085257133.1\|1784060_1785167_-\|2-oxoacid:ferredoxin-oxidoreductase-subunit-beta	unknown	unknown	gnl\|CDD\|237006

Protein	Function_ID	Function_description	E-value
NZ_AP022573.1\|WP_085258008.1\|1772260_1775140_-\|Rne/Rng-family-ribonuclease	gnl\|CDD\|273254	TIGR00757, Ribonuclease_E/G-like_protein, ribonuclease, Rne/Rng family. This model describes ribonuclease G (formerly CafA, cytoplasmic axial filament protein A), the N-terminal domain of ribonuclease E in which ribonuclease activity resides, and related proteins. In E. coli, both RNase E and RNase G have been shown to play a role in the maturation of the 5' end of 16S RNA. The C-terminal half of RNase E (excluded from the seed alignment for this model) lacks ribonuclease activity but participates in mRNA degradation by organizing the degradosome. [Transcription, Degradation of RNA].	0
NZ_AP022573.1\|WP_085254965.1\|1791119_1791710_-\|ATP-dependent-CLP-protease-proteolytic-subunit-ClpP1	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	1.04434e-112
NZ_AP022573.1\|WP_085257132.1\|1785163_1787140_-\|2-oxoacid:acceptor-oxidoreductase-subunit-alpha	gnl\|CDD\|274738	TIGR03710, OAFO_sf, 2-oxoacid:acceptor oxidoreductase, alpha subunit. This family of proteins contains a C-terminal thiamine diphosphate (TPP) binding domain typical of flavodoxin/ferredoxin oxidoreductases (pfam01855) as well as an N-terminal domain similar to the gamma subunit of the same group of oxidoreductases (pfam01558). The genes represented by this model are always found in association with a neighboring gene for a beta subunit (TIGR02177) which also occurs in a 4-subunit (alpha/beta/gamma/ferredoxin) version of the system. This alpha/gamma plus beta structure was used to define the set of sequences to include in this model. This pair of genes is not consistantly observed in proximity to any electron acceptor genes, but is found next to putative ferredoxins or ferredoxin-domain proteins in Azoarcus sp. EbN1, Bradyrhizobium japonicum USDA 110, Frankia sp. CcI3, Rhodoferax ferrireducens DSM 15236, Rhodopseudomonas palustris BisB5, Os, Sphingomonas wittichii RW1 and Streptomyces clavuligerus. Other potential acceptors are also sporadically observed in close proximity including ferritin-like proteins, reberythrin, peroxiredoxin and a variety of other flavin and iron-sulfur cluster-containing proteins. The phylogenetic distribution of this family encompasses archaea, a number of deeply-branching bacterial clades and only a small number of firmicutes and proteobacteria. The enzyme from Sulfolobus has been characterized with respect to its substrate specificity, which is described as wide, encompassing various 2-oxoacids such as 2-oxoglutarate, 2-oxobutyrate and pyruvate. The enzyme from Hydrogenobacter thermophilus has been shown to have a high specificity towards 2-oxoglutarate and is one of the key enzymes in the reverse TCA cycle in this organism. Furthermore, considering its binding of coenzyme A, it can be reasonably inferred that the product of the reaction is succinyl-CoA. The genes for this enzyme in Prevotella intermedia 17, Persephonella marina EX-H1 and Picrophilus torridus DSM 9790 are in close proximity to a variety of TCA cycle genes. Persephonella marina and P. torridus are believed to encode complete TCA cycles, and none of these contains the lipoate-based 2-oxoglutarate dehydrogenase (E1/E2/E3) system. That system is presumed to be replaced by this one. In fact, the lipoate system is absent in most organisms possessing a member of this family, providing additional circumstantial evidence that many of these enzymes are capable of acting as 2-oxoglutarate dehydrogenases and.	0
NZ_AP022573.1\|WP_085258013.1\|1780415_1781675_-\|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein	gnl\|CDD\|225807	COG3268, COG3268, Uncharacterized conserved protein [Function unknown].	1.13998e-142
NZ_AP022573.1\|WP_085254964.1\|1791837_1793271_-\|trigger-factor	gnl\|CDD\|234956	PRK01490, tig, trigger factor; Provisional.	2.77058e-153
NZ_AP022573.1\|WP_085258010.1\|1775885_1776272_-\|DUF4233-domain-containing-protein	gnl\|CDD\|379420	pfam14017, DUF4233, Protein of unknown function (DUF4233). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 122 and 147 amino acids in length. Proteins in this family are integral membrane proteins.	3.17976e-26
NZ_AP022573.1\|WP_085258006.1\|1771444_1771699_-\|50S-ribosomal-protein-L27	gnl\|CDD\|235464	PRK05435, rpmA, 50S ribosomal protein L27; Validated.	2.2937e-48
NZ_AP022573.1\|WP_142280517.1\|1796526_1797015_-\|ribose-5-phosphate-isomerase	gnl\|CDD\|235509	PRK05571, PRK05571, ribose-5-phosphate isomerase B; Provisional.	7.3262e-88
NZ_AP022573.1\|WP_085254966.1\|1790478_1791123_-\|ATP-dependent-CLP-protease-proteolytic-subunit-ClpP2	gnl\|CDD\|237133	PRK12553, PRK12553, ATP-dependent Clp protease proteolytic subunit; Reviewed.	9.25905e-132
NZ_AP022573.1\|WP_085258012.1\|1777734_1780389_-\|valine--tRNA-ligase	gnl\|CDD\|235582	PRK05729, valS, valyl-tRNA synthetase; Reviewed.	0
NZ_AP022573.1\|WP_085258005.1\|1769927_1771382_-\|GTPase-ObgE	gnl\|CDD\|237045	PRK12296, obgE, GTPase CgtA; Reviewed.	0
NZ_AP022573.1\|WP_085258009.1\|1775445_1775856_-\|nucleoside-diphosphate-kinase	gnl\|CDD\|179085	PRK00668, ndk, mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated.	5.49041e-81
NZ_AP022573.1\|WP_085258007.1\|1771713_1772025_-\|50S-ribosomal-protein-L21	gnl\|CDD\|235510	PRK05573, rplU, 50S ribosomal protein L21; Validated.	1.21487e-43
NZ_AP022573.1\|WP_085254960.1\|1795722_1796523_-\|Fpg/Nei-family-DNA-glycosylase	gnl\|CDD\|223344	COG0266, Nei, Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair].	2.48086e-76
NZ_AP022573.1\|WP_085257131.1\|1787541_1788822_-\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpX	gnl\|CDD\|235422	PRK05342, clpX, ATP-dependent Clp protease ATP-binding subunit ClpX.	0
NZ_AP022573.1\|WP_085257134.1\|1783437_1784046_-\|molybdenum-cofactor-guanylyltransferase	gnl\|CDD\|234798	PRK00576, PRK00576, molybdopterin-guanine dinucleotide biosynthesis protein A; Provisional.	4.43834e-81
NZ_AP022573.1\|WP_085254963.1\|1793649_1794858_+\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.99426e-61
NZ_AP022573.1\|WP_085258011.1\|1776268_1777738_-\|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	gnl\|CDD\|223362	COG0285, FolC, Folylpolyglutamate synthase [Coenzyme metabolism].	6.39353e-147
NZ_AP022573.1\|WP_085258004.1\|1768818_1769931_-\|glutamate-5-kinase	gnl\|CDD\|235460	PRK05429, PRK05429, gamma-glutamyl kinase; Provisional.	9.94492e-176
NZ_AP022573.1\|WP_085257133.1\|1784060_1785167_-\|2-oxoacid:ferredoxin-oxidoreductase-subunit-beta	gnl\|CDD\|237006	PRK11867, PRK11867, 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed.	2.72939e-173

>NZ_AP022573.1|WP_085258013.1|1780415_1781675_-|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein
MTVTPREYDLVLYGATGFVGKLTAEYLATAAGDARIALAGRSTDRLRAIRDGLGEPARSWGLLAADAASPSTLNEMATRAQVVVTTVGPYTRYGLPLVAACAAAGTDYADLTGEPPFMRDSIDTYHKQAADTGARIVHACGFDSVPSDLTVYALYRAARHDGAGELGDTDFVVRSLRGGLSGGTIASLLEVLDAASGDPDVRRQLNDPYTLSTDRAAEPELGRQPDLPWRRGRQIAPELSGLWTGGFMMAPANTRIVRRSNALMGWPYGRGFRYTESMSLGSSPLAPLASAVLSGVGNATMGLGGRYFRLLPRQLVERVVPKPGTGPSAAARDRGFYRIETYTTTTTGARYVARMEQRGDPGYKATSVLLGECGLALALDRDKLSDLRGVLTPAAAMGDALLARFPAAGVSLQVDRLGG
>NZ_AP022573.1|WP_085258012.1|1777734_1780389_-|valine--tRNA-ligase
MTDSRSAADLPKSWDPGAMEGPIYQGWVDAGYFTADPTSPKPGYSIVLPPPNVTGSLHMGHALEHTMMDALTRRKRMQGYEVLWQPGMDHAGIATQSVVEKQLAVDGKTKEEFGRELFVEKVWDWKRESGGAISGQMRRLGDGVDWSRDRFTMDEGLSRAVRTIFKRLYDAGLIYRAERLVNWSPVLETALSDIEVNYEEVEGELVSFRYGSLDDSQPHIVVATTRVETMLGDSAIAVHPDDERYRHLVGSTLPHPFLDRRLVIVADKHVDPEFGTGAVKVTPAHDPNDFEIGLRHQLPMISIMDTKGRIANTGTQFDGMDRFEARVAVREALAAQGRIVEEKRPYLHSVGHSERSGEPIEPRLSLQWWVRVESLAKAAGDAVRNGDTVIHPASMEPRWFAWVDDMHDWCISRQLWWGHRIPIWYGPDGEQVCVGPDETPPEGWEQDPDVLDTWFSSGLWPFSTLGWPAQTPELEKFYPTSVLVTGYDILFFWVARMMMFGTFVGDDDAITLGGRRGPQVPFTDVFLHGLIRDESGRKMSKSKGNVVDPLDWMDTFGADALRFTLARGASPGGDLAIGEDHVRASRNFCTKLFNATRYALLNGAALQELPSSDQLTDADRWILGRLEEVRAEVDSALDAYEFSRACEALYHFAWDEFCDWYVELAKTQLSEEGAHTTAVLAAVLDTMLRLLHPVIPFLTESLWRALTNRESLVVADWPKPSGVSLDPVAAQRISDMQRLVTEVRRFRSEQGLADRQKVPARLGGVDGAGLSAQVAAVTSLAWLTAPGDDFQPSVSLEVRLGPDSNSTVVVELDTSGTIDVAAERRRLEKDLAAAQKELTSTAAKLGNADFLAKAPEHVVAKIRDRQRLAQDETDRITARLAALK
>NZ_AP022573.1|WP_085258011.1|1776268_1777738_-|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase
MSDSPEWGPDIQPEDPHVDVAPTPDEIAALWQVEHLLDQRWPETRIEPSLTRISALMDLLGSPQLGYPSIHITGTNGKTSVARMVDALVTALGRRTGRTTSPHLQSAVERISIDSKPISPAQYVATYREIEPFVQMVDAQSQAEGGPAMSKFEVLTGMAFAAFADAPVDVAVVEVGMGGRWDATNVVGAPVAVITPIAIDHVEYLGDDIAGIAGEKAGIIAKAPEGAPDTVAVIGRQVPEAMEVLLAQSVRADAAVAREDSEFAVLGRQVAIGGQVLQLQGLGGVYSDIFLPLHGEHQAHNAVVALAAVEAFFGAGAQRQLDVDAVRAGFAAVTSPGRMERMRSAPTVFIDAAHNPAGAAALAQTLTDEFDFRFLVGVIGVLADKDFGGILAALEPVFDQVVVTHNGSPRALDVESLALAAQERFGPDRVATAENLRDAIDVATALVDDALRDGLVEGEAEAFSGTGIVITGSVVTAGAARTLFGRDPE
>NZ_AP022573.1|WP_085258010.1|1775885_1776272_-|DUF4233-domain-containing-protein
MSEQDPAPAGDPWKSFGAVMAATLVLEAIVVLLAIPVVGAVGGGLTSASLAYLVGLATLLILLAGLQRRPWAIWVNLGVQIPLLAGFAVYPGVGFVGVLFTGLWALIAYFRAEVRRREAGRGKAQPPG
>NZ_AP022573.1|WP_085258009.1|1775445_1775856_-|nucleoside-diphosphate-kinase
MTERTLVLIKPDGVERRLIGGILSRIEQKGLTIAALELRHVAEDLAAQHYAEHEGKPFFGSLLEFITSGPVVAAIVEGPRAIAAFRQLAGGTDPVEKASPGTIRGDFGLETQFNLVHGSDSTDSAKREIALWFPNS
>NZ_AP022573.1|WP_085258008.1|1772260_1775140_-|Rne/Rng-family-ribonuclease
MVDGAPPTEPTQEPTGHEDLPDRLRVHQLARALGSTNKEVLDALVSLDGRTRNVQSGVDREDALRVRDLIFAKPLPNIPGFSSAPAPVVARPVSRPPAESPGEPPQYMPLFVAPQPIEKDRGGAGDASDIDTDYDSEDADTDDDEEQADRPANRRRRRGRRGRGRGRGEQGGPDGQDAGEDDAESDSDDEDSEDSDDSDAGDEEGGSSEGATRRRRRRRRRKSGSADDNDETSSPDDPPNTVVHERPPRSGKGGGADGNGSSNAEIKGIDGSTRLEAKRQRRRDGRDAGRRRPPVLTEAEFLARREAVERVMVVRDRIRTEPPHPGSRYTQIAVLEDGIVVEHFVTSAASASLVGNIYLGIVQNVLPSMEAAFVDIGRGRNGVLYAGEVNWEAAGLGGSDRKIEQALKPGDYVVVQVSKDPVGHKGARLTTQVSLAGRYLVYVPGASSTGISRKLPDTERQRLKEILREVVPSDAGVIIRTASEGVKEDDIRGDVTRLQERWKQIEAKAREIKEKAAGAAVALYEEPDVLVKVIRDLFNEDFAGLIVSGDEAWNTITEYVNSVAPDLVSKLNKYETADSSEGIPAPDVFAVHRIDEQLAKAMDRKVWLPSGGTLVIDRTEAMTVIDVNTGKFTGSGGNLEQTVTKNNLEAAEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVLRRLTEALARDRTRHQVSEVTSLGLVQLTRKRLGTGLIEAFSTACPNCGGRGVLLHADPVESTSSNGRKAESGGRRGRRSKKGRSDETAEQPTVAKVPAHAPGEHPMFKAMAAGNGRDDEESDETGEAGESADTDERTLAGATAGREDFGGVGDTEDIEDSDEDELDDEDELDDEEDLGDDDEDVGLDDDDNDDDDTDDSDDDDDSDDDDDSDDDDDTDDDDSDDDDDNEDEDDFDGSEDSDVGGPRGAVEVQSMFGRPRRRRAAGRPAGPPIHAD
>NZ_AP022573.1|WP_085258007.1|1771713_1772025_-|50S-ribosomal-protein-L21
MATYAIVKTGGKQYKVAVGDVVKVEKLDSEPGSSVSLPVALVVDGANVTTDAGTLANVAVTGEVLEHTKGPKIRIHKFRNKTGYHKRQGHRQRLTVLKVTGIK
>NZ_AP022573.1|WP_085258006.1|1771444_1771699_-|50S-ribosomal-protein-L27
MAHKKGASSSRNGRDSAAQRLGVKRFGGQLVKAGEIIVRQRGTKFHPGVNVGRGGDDTLFAKETGAVEFGVKRGRKTVSIVAAD
>NZ_AP022573.1|WP_085258005.1|1769927_1771382_-|GTPase-ObgE
MPRFIDRVTIHARAGSGGNGCASVHREKFKPLGGPDGGNGGRGGSVVLVVDPQVHTLLDFHFRPHVTAPSGKQGMGNNRDGAAGADLEVKVPDGTVVLDGNGRLLADLVGPGTRFEAAAGGRGGLGNAALASRARKAPGFALLGEEGEARDLTLELKTVADVGLIGFPSAGKSSLVSAISAAKPKIADYPFTTLAPNLGVVSAGEHTFTVADVPGLIPGASQGRGLGLDFLRHIERCAVLVHVVDCATAEPGRDPISDIAALEAELAAYTPTLQGDAALGDLAERPRAVVLNKIDVPEARELAEFVRDEIAERGWPVFLVSTVSREGLQPLIFGLWRMVSEYNAALPPVVPRRPVIRPVPVDNSGFSVEPDGQGGFVVSGARPERWVRQTAFENDEAVGYLADRLARLGVEDELLRLGAEPGCAVTIGDMTFDWEPQTPAGQHVAMSGRGTDVRLEQSERVGAAERKAARRQRRERAGESDGTP
>NZ_AP022573.1|WP_085258004.1|1768818_1769931_-|glutamate-5-kinase
MSAHREAIRTARSLVVKVGTNALTTPSGMFEAGRLAGLADAIEARMKAGTDVVIVSSGAIAAGMEPLGLSRRPKDLATKQAAASVGQVALVNSWSAAFARYGRTVGQVLLTAHDISMRAQHTNAQRTLDRLRALHAVAIVNENDTVATNEIRFGDNDRLSALVAHLVGAEALVLLSDIDGLYDADPRKTKGARFIPEVSGTADLDGVVAGPGSALGTGGMASKMSSALLAADAGVPVLLAAADDAATALTDASSGTVFAARPARMSARRFWVRYAAESAGSLTLDAGAVRAVVQQRRSLLAAGITAVAGRFYGGDVVELRGPDAAMVARGVVAYDAAELASMMGRSTSELPGELRRPAVHADDLVVVQAA
>NZ_AP022573.1|WP_085257134.1|1783437_1784046_-|molybdenum-cofactor-guanylyltransferase
MPDAVSLAGVVLAGGASRRMGRDKASMPVPGSSGGAGATTMVEQVVAVLRQRCEPVLVMAAQGQPLPPVQAQIVRDELRGLGPLAATARALRTAAEAGAGFAFVCAVDMPFLAADLIDELTRMAVETGAEVVLPWDGQDHYLAAVYRTDLADRADALVAAGERKMRALVDSSDAQRIVTSDSRSLTNVNTESDLRALTPSRV
>NZ_AP022573.1|WP_085257133.1|1784060_1785167_-|2-oxoacid:ferredoxin-oxidoreductase-subunit-beta
MTDLMGNLAGADLGLAPGGDNRRLTKNDGVPTTDQPQKAKDFTSDQEVRWCPGCGDYVILNTIRNFLPELGLRRENIVFISGIGCSSRFPYYLETYGFHSIHGRAPAIATGLALAREDLSVWVVTGDGDALSIGGNHLIHALRRNVNITILLFNNRIYGLTKGQYSPTSEVGKVTKSTPMGSLDQPFNPVSLALGAEATFVGRALDSDRNGLSEVLRAAAEHRGAAVVEILQDCPIFNDGSFDALRKEGAEERVINVRDGEPIVFGADGEYCVVKSGFGLDVAKTADVAVDEIVVHDAHAEDSAYAFALSRLSDQNLEHTVLGIFRNVSRPTYDDAARSQVRTARASSPFDTGALQSLLRGRDTWTVD
>NZ_AP022573.1|WP_085257132.1|1785163_1787140_-|2-oxoacid:acceptor-oxidoreductase-subunit-alpha
MDPNGTGAGSNSHESNSRNGASNNGSSRQRIEQVVIRFAGDSGDGMQLTGDRFTSEAALFGNDLATQPNYPAEIRAPAGTLPGVSSFQIQIADYDILTAGDRPDVLVAMNPAALKANIGDLPRGGMVIVNSDEFTKRNLTKVGYVTNPLESDELSEYVVHSVAMTTLTLGAVEAIGASKKDGQRAKNMFALGLLSWMYGRPIETSERFIREKFARKPDVAEANVLALKAGWNYGETTEAFGTTYEVSRASLPAGEYRQISGNTALAYGIVAAGQLAGIQVVLGSYPITPASDILHELSKHKNFNVITFQAEDEIGGICAAIGASYGGALGVTSTSGPGLSLKSEALGLAVMTELPLLVIDVQRGGPSTGLPTKTEQADLLQALYGRNGESPVAVLAPRSPSDCFETAIEAVRIAVSYHTPVIVLSDGAIANGSEPWRIPDVGTLNPIKHTFAKPDEPFQPYNRDPETLARQFAVPGTPGLEHRIGGLEAANGSGNISYEPVNHDLMVRLRQAKIDGIDVPDLEVDDPTGDAELLLIGWGSSYGPIGEACRRARRRGVKVAHAHLRHLSPFPANLGDVLRRYPQVVAPEMNLGQLALLLRGKYLVDVQSVTKVQGVAFLADEIGRLIRAALAGTLAEIEEDKTMVARMSAATVGAGASE
>NZ_AP022573.1|WP_085257131.1|1787541_1788822_-|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpX
MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELADADDVKLDELPKPVEIRDFLEGYVIGQDTAKRTLAVAVYNHYKRIQAGEKSRDSRHEPVELTKSNILMLGPTGCGKTYLAQTLAKMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSITRDVSGEGVQQALLKILEGTQASVPPQGGRKHPHQEFIQIDTTNVLFIVAGAFAGLEKIIYERVGKRGLGFGAEVRSKAEIDTTDHFAEVMPEDLIKFGLIPEFIGRLPVVASVTNLDKESLVKILSEPKNALVKQYTRLFEMDAVELEFTEDALEAIADQAIHRGTGARGLRAIMEEVLLPVMYDIPSRDDVAKVVVTKETVQDNVLPTIVPRKPSRAERRDKTA
>NZ_AP022573.1|WP_085254966.1|1790478_1791123_-|ATP-dependent-CLP-protease-proteolytic-subunit-ClpP2
MNPLDPRTQPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQLLVLESLDPDRDITMYINSPGGGFTSLMAIYDTMQYVRADIQTVCLGQAASAAAVLLAAGTPGKRMALPNARVLIHQPSLSGVIQGQFSDLEIQAAEIERMRTLMETTLARHTGKDAATIRKDTDRDKILTADEAKDYGIIDTVLEYRKLSAQTA
>NZ_AP022573.1|WP_085254965.1|1791119_1791710_-|ATP-dependent-CLP-protease-proteolytic-subunit-ClpP1
MRSPSQGLTLTDSVYERLLSERIIFLGSEVNDEVANRLCAQILLLAAEDAEKDISLYINSPGGSISAGMAIYDTMVLAPCDIATYAMGMAASMGEFLLAAGTKGKRYALPHARILMHQPLGGVTGSAADIAIQAEQFHVIKKEMFRLNAEFTGQSIERIEADSDRDRWFTAPEALEYGFVDHIITRAAHITNGEAQ
>NZ_AP022573.1|WP_085254964.1|1791837_1793271_-|trigger-factor
MKSSVEQLSPTRVRINVEVPFVELEPEFKRAYKELAKQVRLPGFRPGKAPAKLLEARIGREAMLDQVVNEALPARYGQAVAESAVHPIGQPDIEVTNKEYGQDLAFTAEVDIRPKIIFPPLSELQVTVDPIEVGDDDVEAELQSLRERFGTLTGVDRPVADGDFVSIDLSATVDGEEVPGAAAQGLSHEVGSGRLIAGLDEALIGLSVDESREFTAKLATGEHAGQDAQVTVTVKSIKQRELPEPDDEFAQLASEFDTIDELRASLRDQVARVKRAEQAEQIRDATLEALLERVEVPVPEAVVQAQVEGTLHNALHSFDHDEGKFEEALAGQGKSREDLETEARAAAEADVKRQLLLDSLADELQVQVGQDDLTERLVMTSRQYGIEPQQLFGYLQENNQLAAMYSDVRRGLAIAAAVESATVTDTAGNTIDTSEFFGKRPKVDEAEPVGETDDEANEADEASAADDAAETHADAAE
>NZ_AP022573.1|WP_085254963.1|1793649_1794858_+|serine-hydrolase
MNDARTTAETSTTIHGSCASEFAGVRKAFERNFALRREVGAAVAVWVDGALVVNLWGGSADAARTRPWRQDTLTTVLSGTKALTATCIHQLADRGEVDLHAPVARYWPEFGQAGKEGITLAMVMGHRSGVIGPNRRMRWEDVADWDFVCEQLAAAEPWWRPNTAQGYHMTTFGFILGEVFRRVTGRTVGHYLRTEIAEPIGADVHIGLSAAEQRRCADRVNKPHARDLLADAQAPGYPTSLDEHPKAGLAVSMGFAGDDELSSHDLQLWRQLEFPGTNGQVSALGLATFYNALAQEKLLSREHMDLVRVCQGGFEPDLVLGPRVADHGWGLGYMLNQRCVNGPNPGIFGHGGLGGSFGFVDLEHRIGYAYVMNRFDATKANADPRSVALSSEVYAALGVAPE
>NZ_AP022573.1|WP_085254960.1|1795722_1796523_-|Fpg/Nei-family-DNA-glycosylase
MPEGHTLHRLARLHQRRFSGAPVAVSSPQGRFASDAVDGRVLLRTSAWGKHLFHHYAGGPIVHVHLGLYGAFTEWPREDGAVLPEPVGQVRMRMVGADHGTDLRGPTVCEVVDEAQVSDVLARLGPDPLRRDADPSWAWTRIAKSRRPIGALLMDQAVIAGVGNVYRSELLFRHRIDPYRPGRGIGEAEFGAAWTDLVALMKVGLRRGKIVVVEPEHDHGPPSYRPGRPRTYVYRRAGEPCRVCGGPVSTAVLEGRNVFWCPTCQK
>NZ_AP022573.1|WP_142280517.1|1796526_1797015_-|ribose-5-phosphate-isomerase
MSGMRVYLGSDHAGYELKQQIIEHLKQSGHEPIDCGAFGYDPEDDYPAFCIDAATRTVADPESLGIVLGGSGNGEQIAANKVPGARCALAWSVETASLARQHNNAQLIGIGGRMHTVEEALSFVDAFLTTPWSKAERHQRRIDILSEYERTHRAPPVPGAPA

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Crispr_ID: NZ_AP022573_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022573_4

4945287-4945394

Orphan

Consensus_repeat	Method
CAAGCGAGCGCGGGGCGGGCGCCCGGCTGGCCGGGCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022573_4

>merge|NZ_AP022573|4|4945287-4945394|CRISPRCasFinder
CAAGCGAGCGCGGGGCGGGCGCCCGGCTGGCCGGGCGCCCGGCCGAAGCGGCCAAGCACTCGGAGGCGGCCAAGCGAGTGCGGGGCGGGCGCCCGGCTGGCCGGGCGC

>NZ_AP022573|4|4|4945287-4945394|CRISPRCasFinder
CAAGCGAGCGCGGGGCGGGCGCCCGGCTGGCCGGGCGC	CCGGCCGAAGCGGCCAAGCACTCGGAGGCGGC
CAAGCGAGTGCGGGGCGGGCGCCCGGCTGGCCGGGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022573.1\|WP_085253655.1\|4949988_4951236_-\|D-alanyl-D-alanine-carboxypeptidase	unknown	unknown	gnl\|CDD\|224600
NZ_AP022573.1\|WP_085253666.1\|4934445_4935906_+\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143432
NZ_AP022573.1\|WP_085253654.1\|4951322_4952654_-\|aspartate-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|235823
NZ_AP022573.1\|WP_085253661.1\|4940884_4943122_+\|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl\|CDD\|377178
NZ_AP022573.1\|WP_085253658.1\|4945461_4946481_+\|tryptophan--tRNA-ligase	unknown	unknown	gnl\|CDD\|234866
NZ_AP022573.1\|WP_085253665.1\|4935953_4936826_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|379263
NZ_AP022573.1\|WP_085253676.1\|4947515_4948616_-\|N-acetylglucosamine-6-phosphate-deacetylase	unknown	unknown	gnl\|CDD\|238434
NZ_AP022573.1\|WP_085253663.1\|4938415_4939081_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_AP022573.1\|WP_085253652.1\|4953578_4954181_-\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NZ_AP022573.1\|WP_085253651.1\|4954286_4955087_-\|succinate-dehydrogenase-iron-sulfur-subunit	unknown	unknown	gnl\|CDD\|235652
NZ_AP022573.1\|WP_158090655.1\|4932490_4932883_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|368658
NZ_AP022573.1\|WP_085253653.1\|4952701_4953643_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|236600
NZ_AP022573.1\|WP_085253662.1\|4939111_4940746_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|341259
NZ_AP022573.1\|WP_085253659.1\|4944412_4945252_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_AP022573.1\|WP_085253650.1\|4955086_4956841_-\|succinate-dehydrogenase-flavoprotein-subunit	unknown	unknown	gnl\|CDD\|236185
NZ_AP022573.1\|WP_085253664.1\|4936937_4938398_+\|cytosine-permease	unknown	unknown	gnl\|CDD\|224374
NZ_AP022573.1\|WP_085253656.1\|4948630_4949992_-\|sugar-porter-family-MFS-transporter	unknown	unknown	gnl\|CDD\|365860
NZ_AP022573.1\|WP_085253660.1\|4943149_4944385_+\|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl\|CDD\|236226
NZ_AP022573.1\|WP_085253657.1\|4946490_4947519_+\|inner-membrane-protein-YhjD	unknown	unknown	gnl\|CDD\|188082
NZ_AP022573.1\|WP_158090654.1\|4932966_4934367_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274522

Protein	Function_ID	Function_description	E-value
NZ_AP022573.1\|WP_085253655.1\|4949988_4951236_-\|D-alanyl-D-alanine-carboxypeptidase	gnl\|CDD\|224600	COG1686, DacC, D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane].	2.35465e-82
NZ_AP022573.1\|WP_085253666.1\|4934445_4935906_+\|aldehyde-dehydrogenase	gnl\|CDD\|143432	cd07114, ALDH_DhaS, Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like. Uncharacterized aldehyde dehydrogenase from Candidatus pelagibacter (DhaS) and other related sequences are present in this CD.	0
NZ_AP022573.1\|WP_085253654.1\|4951322_4952654_-\|aspartate-aminotransferase-family-protein	gnl\|CDD\|235823	PRK06541, PRK06541, aspartate aminotransferase family protein.	0
NZ_AP022573.1\|WP_085253661.1\|4940884_4943122_+\|NADP-dependent-isocitrate-dehydrogenase	gnl\|CDD\|377178	pfam03971, IDH, Monomeric isocitrate dehydrogenase. NADP(+)-dependent isocitrate dehydrogenase (ICD) is an important enzyme of the intermediary metabolism, as it controls the carbon flux within the citric acid cycle and supplies the cell with 2-oxoglutarate EC:1.1.1.42 and NADPH for biosynthetic purposes.	0
NZ_AP022573.1\|WP_085253658.1\|4945461_4946481_+\|tryptophan--tRNA-ligase	gnl\|CDD\|234866	PRK00927, PRK00927, tryptophanyl-tRNA synthetase; Reviewed.	0
NZ_AP022573.1\|WP_085253665.1\|4935953_4936826_+\|SDR-family-oxidoreductase	gnl\|CDD\|379263	pfam13561, adh_short_C2, Enoyl-(Acyl carrier protein) reductase.	3.03591e-78
NZ_AP022573.1\|WP_085253676.1\|4947515_4948616_-\|N-acetylglucosamine-6-phosphate-deacetylase	gnl\|CDD\|238434	cd00854, NagA, N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to amino-sugar-nucleotides, which is needed for cell wall peptidoglycan and teichoic acid biosynthesis. Deacetylation of N-acetylglucosamine is also important in lipopolysaccharide synthesis and cell wall recycling.	3.06559e-142
NZ_AP022573.1\|WP_085253663.1\|4938415_4939081_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	1.1398e-30
NZ_AP022573.1\|WP_085253652.1\|4953578_4954181_-\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	2.01282e-28
NZ_AP022573.1\|WP_085253651.1\|4954286_4955087_-\|succinate-dehydrogenase-iron-sulfur-subunit	gnl\|CDD\|235652	PRK05950, sdhB, succinate dehydrogenase iron-sulfur subunit; Reviewed.	1.17212e-143
NZ_AP022573.1\|WP_158090655.1\|4932490_4932883_+\|cupin-domain-containing-protein	gnl\|CDD\|368658	pfam05899, Cupin_3, Protein of unknown function (DUF861). This family consists of several proteins which seem to be specific to plants and bacteria. The function of this family is unknown.	9.33466e-07
NZ_AP022573.1\|WP_085253653.1\|4952701_4953643_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|236600	PRK09636, PRK09636, RNA polymerase sigma factor SigJ; Provisional.	3.37377e-151
NZ_AP022573.1\|WP_085253662.1\|4939111_4940746_+\|AMP-binding-protein	gnl\|CDD\|341259	cd05936, FC-FACS_FadD_like, Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD. This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.	1.75257e-154
NZ_AP022573.1\|WP_085253659.1\|4944412_4945252_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.13953e-18
NZ_AP022573.1\|WP_085253650.1\|4955086_4956841_-\|succinate-dehydrogenase-flavoprotein-subunit	gnl\|CDD\|236185	PRK08205, sdhA, succinate dehydrogenase flavoprotein subunit; Reviewed.	0
NZ_AP022573.1\|WP_085253664.1\|4936937_4938398_+\|cytosine-permease	gnl\|CDD\|224374	COG1457, CodB, Purine-cytosine permease and related proteins [Nucleotide transport and metabolism].	9.77911e-67
NZ_AP022573.1\|WP_085253656.1\|4948630_4949992_-\|sugar-porter-family-MFS-transporter	gnl\|CDD\|365860	pfam00083, Sugar_tr, Sugar (and other) transporter.	9.36602e-85
NZ_AP022573.1\|WP_085253660.1\|4943149_4944385_+\|NADP-dependent-isocitrate-dehydrogenase	gnl\|CDD\|236226	PRK08299, PRK08299, NADP-dependent isocitrate dehydrogenase.	0
NZ_AP022573.1\|WP_085253657.1\|4946490_4947519_+\|inner-membrane-protein-YhjD	gnl\|CDD\|188082	TIGR00766, Uncharacterized_protein_Dda3937_02003, inner membrane protein YhjD. This family, including YhjD in E. coli, is a conserved inner membrane protein homologous YihY, which in turn was incorrectly assigned to be ribonuclease BN. This, any suggestion this family is similar to ribonucleases should be removed. [Transcription, Degradation of RNA].	2.83753e-92
NZ_AP022573.1\|WP_158090654.1\|4932966_4934367_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|274522	TIGR03329, Phn_aa_oxid, putative aminophosphonate oxidoreductase. This clade of sequences are members of the pfam01266 family of FAD-dependent oxidoreductases. Characterized proteins within this family include glycerol-3-phosphate dehydrogenase (1.1.99.5), sarcosine oxidase beta subunit (1.5.3.1) and a number of deaminating amino acid oxidases (1.4.-.-). These genes have been consistently observed in a genomic context including genes for the import and catabolism of 2-aminoethylphosphonate (AEP). If the substrate of this oxidoreductase is AEP itself, then it is probably acting in the manner of a deaminating oxidase, resulting in the same product (phosphonoacetaldehyde) as the transaminase PhnW (TIGR02326), but releasing ammonia instead of coupling to pyruvate:alanine. Alternatively, it is reasonable to suppose that the various ABC cassette transporters which are also associated with these loci allow the import of phosphonates closely related to AEP which may not be substrates for PhnW.	2.22727e-114

>NZ_AP022573.1|WP_085253659.1|4944412_4945252_-|alpha/beta-hydrolase
MGNRPPIHLGSGEPVLLLHPFLLSQAVWEGVARRLADTGRYEVFAPTMAGHNGGPRAGTWFLSSAVLADHVERQMDELGWDTAHIVGNSLGGWVAFELERRGRARSVTGIAPAGGWTRWSPHKFEVIFKFVLGIPLLLLAWAFGPRVMRLPYSRRLATYAISGSPDAISDADILTCIDDVAHCPAYFQLLVKATLLHGLRELADNAVPAHLVVCEKDRVIPAPRFSRHFTNHLPDHQVTELDGVGHVPMFEAPDRVAEVISGFIDECTRETRDRQQPAG
>NZ_AP022573.1|WP_085253660.1|4943149_4944385_+|NADP-dependent-isocitrate-dehydrogenase
MSDGSKIKVKGPVVELDGDEMTRVIWKFIKDLLILPHLDINLEYYDLGIENRDRTNDQVTIDAAYAIKRHGVGVKCATITPDEARVSEFNLKKMWLSPNGTIRNILGGTIFREPIVISNVPRLVPGWTKPIVIGRHAFGDQYRATNFKVDKPGAVSITFTPSDGSEPIVHEVVSIPEDGGVVMGMYNFKESVRDFARASLAYGLNAKWPVYLSTKNTILKAYDGMFKDEFQRIYDEEFKDKFEAEGLTYEHRLIDDMVAACLKWEGGYVWACKNYDGDVQSDLVAQGYGSLGLMTSVLMTADGKTVEAEAAHGTVTRHFRQYQAGKPTSTNPIASIFAWTRGLQHRGKLDNTPEVIEFAQTVESVVIATVESGKMTKDLAILIGPDQEWQQSEQFLNSIAENLDKKLAGAD
>NZ_AP022573.1|WP_085253661.1|4940884_4943122_+|NADP-dependent-isocitrate-dehydrogenase
MSAEQPTVIYTLTDEAPLLATYALLPIVRAFAEPAGITIKTSDISVAARILAEFPEHLTEDQRVPDDLGELGRLTKLPDTNIIKLPNISASVPQLIAAVKELQGKGFKVPDFPQSPKTDEDKAIRERYAKCLGSAVNPVLREGNSDRRAPKAVKEYARKHPHSMGEWSPASRTHVATMRHGDFYHGEKSMTLDHARDVKMVLRTESGETLELKPKVELRAGDVIDSMFMSKKALCEFYEQQMQDAYETGVMFSLHVKATMMKVSHPIVFGHAVKIFYKDAFAKHQELFDELGVNVNNGLVDLYNKIESLPASLHEEIIRDLHACHEHRPELAMVDSAKGITNFHSPSDVIVDASMPAMIRAGGKMWGADGRQKDTKAVNPESTFSRIYQEMINFCKTNGQFDPTTMGTVPNVGLMAQQAEEYGSHDKTFEVPEDGVADIVDLDTGEVLLTQNVEAGDIWRMPIVTDAAIRDWVKLAVTRARNSGMTVVFWLDTERPHEVELRKKVKQYLKEHDTEGLEIQIMPQVWAMRYTIERAVRGQDTIAATGNILRDYLTDLFPILELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVHQLVEENHLRWDSLGEFLALGACFEDIGIKTGNERAKILGKTLDAAIGKLLDNNKSPSRKTGELDNRGSQFYLALYWAEQLAAQSDDEELRKHFAALADALSKNEDTIVAELAEAQGEAVDIGGYYRPDSEKTTAVMRPSKTFNEALARSQG
>NZ_AP022573.1|WP_085253662.1|4939111_4940746_+|AMP-binding-protein
MAPTSPEASSPVHAVATRGGHSSLVDAWRARVKREPDARAIAYFDGAMTVREFDEASDALAAGFRSLGTSRGDRVGIYLQNIPQYALSFLALWKLGATALLLNPMYRGHELRRLIDDAEAVGIVCTDDDVAETSATLAGSSVRWVVSTSPLAFQSRNDPRVFDTDERVARDTDRDLENLIAQFRGRSAPRLDLTSDEVALLTYTSGTTGPPKGATNTHGNLLAVTDSFAAWIDLQPGDAVFAMAPFFHITGAVVNAAMALLHDAILVLVNRFHPEVAIEAFVEHGVTFTIGSITAFNSISRLPHASHEHFASLKSVYSGGAPIPPSTVGQFMQRFGVYIHNVYGMTETSSAVIGVPLGAEAPVDRASGALSIGRPLHGMEVRVVDASGRPVIPHVQGELVLRGPQVVPGYWRNPEATASTMPDGWLHTGDGAIVDEDGWVYLVDRLKDQINTSGYKVWPREVEDVLSAHPAVFEAAVVGTPDEYRGEAVVAYVSLNGGETATEAEMIAFARERLAAYKCPRAIRVVPELPKTQTGKIRRNAVRE
>NZ_AP022573.1|WP_085253663.1|4938415_4939081_+|histidine-phosphatase-family-protein
MTEILLIRHGQPRPGYVDPPLSPVGRHQSERLGRWLAGERVDAVVASPMARALETAEVAAHEMALAVAGTLEDLREWDRDHRSDGTYVAIEDLGDDNPRSHALRTGRYEYFVPDIDRTGFLSRARRVVDELSDRWPGRRVAAFSHGGLINAALSTVLGLEEQLFFFLPDYTSVSTVRVMPGGRRVVHALNNTSHLVGQRVPEPDSMLARRPGADRPIIRTQ
>NZ_AP022573.1|WP_085253664.1|4936937_4938398_+|cytosine-permease
MAVQEEPKVGVVNQIELHSIDYVPLRARHGRLVDQTTIWFACFHPLTLVTGAIGIGLGLNLIWTLLGVALGTLFGTIPVSIHATQGPHLGLPQMVQTRPQFGRYGALFIWVMAIVVYWGYLVVGGNIFGTNLHQFVGGSAPVWAIVTGVVAIVLAIFGYRWLHSAQRIVSIGLVIVLVIYIAGLAVGGYIPGNALNLGETFQPVPFAVTVSAAMAYQLSWAFFVSDYSRYMPPDTNRGAIILWTSIGLYFSVFAYEAVGAMAAAMLPGDDIIASVSATGDHVFPGLGTLMLLVFGLGLLGLMGMCVYGGSLTLITAIDSIRPVDVSRSIRVVTILLLGGSSAIAGAFLPDNFLNTVFLVVLEVFAYLMAPWTSVNLTDFFIVRRGHYSVREIFKRDGIYGRWNWRGIMAYTVTFLVMIPFMHASHFEGPISAALGGIDVAFFVGVPVGCLTYWLLCRNLDMATEREVVKESDRDLEPVVRDLEAIA
>NZ_AP022573.1|WP_085253665.1|4935953_4936826_+|SDR-family-oxidoreductase
MDGKGLVNGLLAGKAVIVTGAGSGIGAAVAKQAAADGANVLLLGRRVDKLEETAAAIGDGALVQRCDVTQQADIDRAVALALARWGRIDGLVNNAGMFVMAHALEMTREQWNQVIDVDLSASFFFTQAAGRVMARAGGGSVVNIASVNGHQGEPLNAPYNASKAGLIGLTRSLAMDLGRFGIRVNSVSPGYVDGTPMADDTGDADEPMSVLLSDWQRAPLRRMVDTPEVANLCTFLLSDRASGMTGSDVVIDGGMLTNHYALESVPATGWASFQDSVTAQVRAKLVSGEL
>NZ_AP022573.1|WP_085253666.1|4934445_4935906_+|aldehyde-dehydrogenase
MHVSERPHYGLFIGGSFVDALDGDVFPSVNPYTGEDWAFMARAASADVDAAVASARRAFELWSRTSGRRRAAHMHSLARVIEKNADRLARIETIDNGKLLADTSRHVRGLPAWLDYFGGLADKLHGTTIPLEEPGLVAYTKREPVGVVAAITPWNAPLAVLLWKLAPALAAGCTMVIKPSEHASASTLELGKLCVEAGLPDGVVNIVTGFGHECGEPLVRHPGIDKVSFTGSTAVGSAVMRTAATNITGVALELGGKSPNIVFDDADPQRASEAAAKAIFSSTGQSCQAGSRLFVQRRLYDDVVRRVAGHAEAMRLGNPLEPSTDMGPVAFRAHLQRIAALVAAAQDEGAALAAGGRAPSAPELGNGYFFEPTVLSEVRNDMTIAQEEVFGPVLAVLPFEDEADVIQQANDSPFGLAAGVWTRDVSRAHRVAANLRAGTVWVNTFRRIDPAMPFGGVKRSGIGRDSGVESLNEYLETKAVWIDTSA
>NZ_AP022573.1|WP_158090654.1|4932966_4934367_+|FAD-dependent-oxidoreductase
MKDRRSIDGKVLWLDPEAGAPTTSAAPSLAGDVEAEFCIVGGGFLGLWTALKLLAAKPDADIILLEAKTCGCGASGRNAGFAMTMWSKAASLTKRATVQDAARLAQASETALTEIAGFCAAEGIDCGFDMSGWLWTANAPAQVGSWESTVRAAESLGGSPFERVSAKDARERLGTDNVFGAVFEEKSAIVDPGRLVLGLRDAVARRGVRLFENSAVKSIDRAGQVVTTDAGSVRCRQLILATNAWLAELPELRRVIVPVSADAVATEPVPDFLDCNWRARESWTNSGTVVDFARPTGDRRVVFGRGAAAIAFRGQIDDRFFVNPPRTLELSTALVQQIPRLFGAAVTHSWSGPVDRTQDGLPIIGRLPGSRALFCAGFAGNGVGPSVVFAQMLASLALGLDDAWAASSYVGIPKYRFPPEPVRYVGALMIRGAVRRHMAASDQGRPSSRLTKRLAELGPTGLMKVK
>NZ_AP022573.1|WP_158090655.1|4932490_4932883_+|cupin-domain-containing-protein
MAGNDSRENLATLAYASSVDAQHLVSMTPEELGLVDVCGNPDMLVHELRSTSGPGGSVWAAVVTVFPCCFNYVFAGNETVLVLEGEATVEVGGTQIVELGPGTIASFTKGTKSRWRIHKRLREFAVLTDT
>NZ_AP022573.1|WP_085253658.1|4945461_4946481_+|tryptophan--tRNA-ligase
MSTPTGPRRIFSGVQPTSDSLHLGNALGAITQWVALQDEHDSFFCVVDLHAITIAQDPAALRHRTLVTAAQYLALGIDPGRSTVFVQSHVPAHTQLAWVLGCFTGFGQASRMTQFKDKSTKQGSDSTTVGLFTYPVLQAADVLAYDSDLVPVGEDQRQHLELARDVAQRFNSRFPDTFVVPDVLIPKVTAKIYDLQDPTSKMSKSASSDAGLINLLDDPAVSAKKIRSAVTDSEREIRYDLEAKPGVSNLLSIQSAVTGVGIDKLVEGYAGRGYGDLKKETAEAVVEYVGPIKARVDELMADRAELESVLAAGSARAEDVAGKTVHRVYDRLGFLPQRE
>NZ_AP022573.1|WP_085253657.1|4946490_4947519_+|inner-membrane-protein-YhjD
MNEPAKPGILDRLRARYDWLDHAVRAYQRFDDRNGGFFAAGLTYYTIFALFPLLMVGFAVFGFLLATRPRLLGTIDDHIRAQVSGPLGNQLLELIDSAIDARTSVGVIGLATAAWGGLSWISHLRQALTEMWWEHCVDSPGFVRNKVSDLLAMGGTFAVTMGTVALTTLGHEQPMAAVLRWAGIPEFLVFEWLFRGISIVVSVLVSWLLFTWMIARLPREKVSVVHSMRAGLMAAVGFEIFKQVASVYLRVVSRSPAGATFGPVLGLMVFAYITAYLVLFCTAWAATTSTDARRRRIEPPPPAIIAPRVQLDEGLSARQTLTAMGLGALVALAFSRLTRWLR
>NZ_AP022573.1|WP_085253676.1|4947515_4948616_-|N-acetylglucosamine-6-phosphate-deacetylase
MVLDGEVARPGWLETSGGRILACGAGPPPRPTHDDFPDCTVVPGFVDMHVHGGGGASYTDPAGIIRAADFHVRQGTTTTLASLVTASPTDLLAGIRALAAASHEGAVAGIHLEGPWLSRARCGAHDPAQTRPPDPAEIEAVLAAGGGAIRMVTLAPELPGAGEAIRRFLDAGVVVAVGHTDATYDQTERAVDAGATVATHLFNAMPPLHHREPGPALALLQDPRVTCELIADGAHVHPAVLRAAIRAAGPGRVALITDAIAAAGCGDGAYTLGAIPIDVESGVARVRGASTIAGSTATMAEIFRVAATLAGVPAAVRMTAATPAGALGLERVGHLRAGHDANLVVLDADLRVRAVMVRGDWRVTRD
>NZ_AP022573.1|WP_085253656.1|4948630_4949992_-|sugar-porter-family-MFS-transporter
MTARPARLRGALVGLTAASVGLIYGYDLSIIAGAQLFVADDFGLTTRQQELLTTMVVLGQIPGALGAGVLANRIGRKGSVLLILVAYAAFALLDAFSVSLPMLLAARFLVGLTIGVSVVVIPVYVAESAPAAVRGSLLTAYQLAVVSGLIVGYLTGYLLAGTHSWRWMLGLAAVPAILLLPLIGRMPDTARWYLLRGRPDDARAALLRVEPTADVDAADAELAEIGRALGEEGGGAAEMLRPPYARATAFVITLGFLIQITGINAIIYYSPRIFAAMGFTGDFALLALPALVQVAGLAAVGVALLLVDRVGRRPILLCGIAMMIVADVILLLVFGRGAGGVIPGFAGVLLFIIGYTMGFGSLGWVYASESFPTRLRSIGSSAMLTSNLVANAIVAAVFLTMLHSLGGAGTFAVFAALAVFALGFVYRYAPETKGRPLEDIRHFWENGGRWEGP
>NZ_AP022573.1|WP_085253655.1|4949988_4951236_-|D-alanyl-D-alanine-carboxypeptidase
MNVLRSASCLAAAAFLTAAPVLFATPGALPKAAAEPNPGPNAAPANCPFKVNTPPAVDSSEAPQAGDPPIPLAVPAKPVGGDALGGCGIVTAPDTPPLPTDVSADAWLVADLDSGAVVAAKDPHGRHRPASIIKVLVAMASINAFNLNKSVPGTAEDAAAEGTKVGVDEGGVFTINQLLHGLLMHSGNDAAHALAMQLGGMQQAVEKINVLAAKLGGRDTRVATPSGLDGPGMSTSAYDIGLFYRYAWQNPTFADIVATRSFDFPGHGDHPGYELENDNQLLYKYPGALGGKTGYTDDAGQTFVGAANRNGRRLMAVLLHGTRVPIAPWEQAAHLLDYGFATPQGTQVGSLIEPDPSLLPKHDSATDRQTGAQAAGLIPSGDAMPVRVGVAVVGTIVVFSLIMVARSMNRRPQHR
>NZ_AP022573.1|WP_085253654.1|4951322_4952654_-|aspartate-aminotransferase-family-protein
MTDNLWLHFTRHGAGATPPIITRGDGVTIYDDRGKSYLDGLSGLFTVQVGHGRTELADVAARQASTLAYFPLWGYATPPAIELAERVAGHTPGDLNRVFFTTGGTEAVETAWKLAKQYFKLTGKPGKHKVISRWVAYHGTTQGALAITGLPKYKAPFEPVTPGGFRVPNTNFYRAPEPFQTDLKAFGRWAADRVAEAIEFEGPDTVAAVFLEPVQNAGGSIPPPPGYFERVREICDAYDVLLVSDEVICAFGRIGSMFACEDFGYVPDMITCAKGLTSGYSPLGAMIASERLFEPFDDGKTMFPHGYTFGGHPVSAAVGLANLDIFEREGLNDRVKQHAAGFRATLEKLYDLPIVGDVRGEGYFYGVELVKDQATKETFTDDERRSLLPRVGAALFENGLYCRTDDRGDSVIQLAPPLISGPAEFDTIEAVLRAVLSEESRRL
>NZ_AP022573.1|WP_085253653.1|4952701_4953643_+|sigma-70-family-RNA-polymerase-sigma-factor
MTSTREVAQFEALRPHLMAVAYRLTGTVADAEDIVQEAWLRWDRQKSDIADLRAWLTTVVSRLGLDRLRSARHRREAYTGNWLPEPVVAPLSREADPLSAVVAREDARFAAMVVLERLSPDQRVAFVLHDGFVVPFAEVARVLGTTEAAARQLASRARKAVAAQPPPEPDPSHDAVVGRLLAAMAAGDVDAVVALLHPDVILTGDSNGKAPTAVQVIHGRDKVVRFMLGLAERYGPAFFTAQQLARVNGELGAYTAGTPGGDGHRGMLPRITAFTVRDGKVCALWDIANPDKFTGSPLRTPARPTESGMPHRN
>NZ_AP022573.1|WP_085253652.1|4953578_4954181_-|carboxymuconolactone-decarboxylase-family-protein
MTQKTRIEPLPPERAGLWTRAMYRIASRRYGQVPEPFAVTAHHRGLMLAGAVHETMIERASKRLPVGVRELAVLWTARSIGCSWCVDFGSMLQRMDGLDVERLNDIDNYATSSAFTDDERAAIRYADAMTTDPHTVTDEQVTDLRARFGDAGVIELTYQIGVENMRARVNSALGITEQGFSSGAACRIPWAAPASAAESR
>NZ_AP022573.1|WP_085253651.1|4954286_4955087_-|succinate-dehydrogenase-iron-sulfur-subunit
MTAGEAVEPRVEPPLPPVPEGAVMVTLKIARFNPDQPDAFAQTGGWQSFRVPCLPSDRLLNLLIYVKSYLDGTLTFRRSCAHGVCGSDAMRINGVNRLACKVLMRDLLPEKPKPGKTLTITVEPIRGLPVEKDLVVDMEPFFDAYRAVKPYLVTTGNPPTRERIQSPTDRARYDDTTKCILCAACTTSCPIFWQEGSYYGPAAIVNAHRFIFDSRDEAAAERLDILNEVDGVWRCRTTFNCTEACPRGIQVTKAIQEVKRALMFTR
>NZ_AP022573.1|WP_085253650.1|4955086_4956841_-|succinate-dehydrogenase-flavoprotein-subunit
MIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGAAQGGMCAALANVEDDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVQFFNEFYALDLVLTQTPSGPVATGVVAYELATGEIHVFHAKAVVLATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFHQFHPTGLAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVLEVLEGRGAGPHKDYVYIDVRHLGEDVLESKLPDITEFARTYLGVDPVHELVPVYPTCHYVMGGIPTTVTGQVLRDNTSTVPGLYAAGECACVSVHGANRLGTNSLLDINVFGRRAGIAAAGFADGHDFVDMPPDPAAMVVGWVGDILSEHGNERVADIRGALQQSMDNNAAVFRTEETLKQALTDIHALKDRYSRITVHDKGKRYNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDVNYMRHTMAYKQGTDLLSDIALDFKPVVQTRYEPKERKY

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Crispr_ID: NZ_AP022573_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022573_5

5540822-5540901

Orphan

Consensus_repeat	Method
GGACTTGACGAGTGGCGACCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022573_5

>merge|NZ_AP022573|5|5540822-5540901|CRISPRCasFinder
GGACTTGACGAGTGGCGACCCGCTTCGCCCGGCTACGCCGCCCTTGCGATCGCCACGGGACTTGACGAGTGGCGACCCGC

>NZ_AP022573|5|5|5540822-5540901|CRISPRCasFinder
GGACTTGACGAGTGGCGACCCGC	TTCGCCCGGCTACGCCGCCCTTGCGATCGCCACG
GGACTTGACGAGTGGCGACCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022573.1\|WP_085255163.1\|5546162_5546750_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_AP022573.1\|WP_085255166.1\|5530928_5532377_+\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_AP022573.1\|WP_085254998.1\|5549422_5549995_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_AP022573.1\|WP_085255000.1\|5541310_5543476_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|236179
NZ_AP022573.1\|WP_085255162.1\|5548412_5549330_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187632
NZ_AP022573.1\|WP_085254996.1\|5550503_5550950_-\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176871
NZ_AP022573.1\|WP_163645174.1\|5539405_5539978_+\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223508
NZ_AP022573.1\|WP_085255164.1\|5544414_5545974_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_AP022573.1\|WP_085255010.1\|5532508_5533477_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|379605
NZ_AP022573.1\|WP_085254997.1\|5549971_5550520_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_AP022573.1\|WP_142280521.1\|5543614_5544358_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_AP022573.1\|WP_085255008.1\|5534522_5536004_-\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_AP022573.1\|WP_085254999.1\|5546850_5548422_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224983
NZ_AP022573.1\|WP_085255004.1\|5538706_5539315_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_AP022573.1\|WP_085255006.1\|5536805_5537738_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181139
NZ_AP022573.1\|WP_085255007.1\|5536130_5536778_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_AP022573.1\|WP_085255005.1\|5537672_5538707_-\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|179564
NZ_AP022573.1\|WP_085255009.1\|5533990_5534512_+\|homocitrate-synthase	unknown	unknown	gnl\|CDD\|273371
NZ_AP022573.1\|WP_085254995.1\|5551192_5552569_+\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|367155
NZ_AP022573.1\|WP_085255002.1\|5540535_5540775_+\|glutaredoxin-like-protein-NrdH	unknown	unknown	gnl\|CDD\|131249

Protein	Function_ID	Function_description	E-value
NZ_AP022573.1\|WP_085255163.1\|5546162_5546750_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	6.73512e-10
NZ_AP022573.1\|WP_085255166.1\|5530928_5532377_+\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	6.11248e-40
NZ_AP022573.1\|WP_085254998.1\|5549422_5549995_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.21674e-09
NZ_AP022573.1\|WP_085255000.1\|5541310_5543476_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha	gnl\|CDD\|236179	PRK08188, PRK08188, ribonucleotide-diphosphate reductase subunit alpha; Validated.	0
NZ_AP022573.1\|WP_085255162.1\|5548412_5549330_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187632	cd05374, 17beta-HSD-like_SDR_c, 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs. 17beta-hydroxysteroid dehydrogenases are a group of isozymes that catalyze activation and inactivation of estrogen and androgens. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	6.57247e-65
NZ_AP022573.1\|WP_085254996.1\|5550503_5550950_-\|SRPBCC-family-protein	gnl\|CDD\|176871	cd08862, SRPBCC_Smu440-like, Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins. This family includes the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of Streptococcus mutans Smu.440 and related proteins. This domain belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Streptococcus mutans is a dental pathogen, and the leading cause of dental caries. In this pathogen, the gene encoding Smu.440 is in the same operon as the gene encoding SMU.441, a member of the MarR protein family of transcriptional regulators involved in multiple antibiotic resistance. It has been suggested that SMU.440 is involved in polyketide-like antibiotic resistance.	2.43674e-40
NZ_AP022573.1\|WP_163645174.1\|5539405_5539978_+\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|223508	COG0431, COG0431, Predicted flavoprotein [General function prediction only].	2.17733e-38
NZ_AP022573.1\|WP_085255164.1\|5544414_5545974_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.21437e-68
NZ_AP022573.1\|WP_085255010.1\|5532508_5533477_+\|sensor-histidine-kinase	gnl\|CDD\|379605	pfam14417, MEDS, MEDS: MEthanogen/methylotroph, DcmR Sensory domain. MEDS is prototyped by DcmR and is likely to function with the PocR domain in certain organisms in sensing hydrocarbon derivatives. The MEDS domain occurs fused to Histidine Kinase and as stand-alone version. Sequence analysis shows that it is a catalytically inactive version of the P-loop NTPase domain of the RecA superfamily.	1.71716e-31
NZ_AP022573.1\|WP_085254997.1\|5549971_5550520_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	6.14561e-06
NZ_AP022573.1\|WP_142280521.1\|5543614_5544358_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	9.18285e-14
NZ_AP022573.1\|WP_085255008.1\|5534522_5536004_-\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	1.29603e-77
NZ_AP022573.1\|WP_085254999.1\|5546850_5548422_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224983	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism].	5.47037e-131
NZ_AP022573.1\|WP_085255004.1\|5538706_5539315_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.04914e-13
NZ_AP022573.1\|WP_085255006.1\|5536805_5537738_+\|SDR-family-oxidoreductase	gnl\|CDD\|181139	PRK07832, PRK07832, SDR family oxidoreductase.	0
NZ_AP022573.1\|WP_085255007.1\|5536130_5536778_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.04096e-10
NZ_AP022573.1\|WP_085255005.1\|5537672_5538707_-\|DNA-polymerase-IV	gnl\|CDD\|179564	PRK03352, PRK03352, DNA polymerase IV; Validated.	0
NZ_AP022573.1\|WP_085255009.1\|5533990_5534512_+\|homocitrate-synthase	gnl\|CDD\|273371	TIGR00970, 2-isopropylmalate_synthase, 2-isopropylmalate synthase, yeast type. A larger family of homologous proteins includes homocitrate synthase, distinct lineages of 2-isopropylmalate synthase, several distinct, uncharacterized, orthologous sets in the Archaea, and other related enzymes. This model describes a family of 2-isopropylmalate synthases as found in yeasts and in a minority of studied bacteria. [Amino acid biosynthesis, Pyruvate family].	1.47369e-07
NZ_AP022573.1\|WP_085254995.1\|5551192_5552569_+\|HNH-endonuclease	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	1.48004e-82
NZ_AP022573.1\|WP_085255002.1\|5540535_5540775_+\|glutaredoxin-like-protein-NrdH	gnl\|CDD\|131249	TIGR02194, Glutaredoxin-like_protein_NrdH, Glutaredoxin-like protein NrdH. NrdH-redoxin is a representative of a class of small redox proteins that contain a conserved CXXC motif and are characterized by a glutaredoxin-like amino acid sequence and thioredoxin-like activity profile. Unlike other the glutaredoxins to which it is most closely related, NrdH aparrently does not interact with glutathione/glutathione reductase, but rather with thioredoxin reductase to catalyze the reduction of ribonucleotide reductase.	2.71455e-38

>NZ_AP022573.1|WP_085255002.1|5540535_5540775_+|glutaredoxin-like-protein-NrdH
MSITVYTKPACVQCNATYKALDKQGIAYDKVDITLDSDARDYVMALGYLQAPVVVAGNDHWSGFRPDRIKALAASALSA
>NZ_AP022573.1|WP_163645174.1|5539405_5539978_+|NAD(P)H-dependent-oxidoreductase
MAETKSDITILTLVGSLRAESINRKIAELAAEVAPEGVAVTVFEGLGELPFYNEDLDPAVGSEAAEPPAAVAALRAAAARADAALVVTPEYNGSIPGVVKNAIDWLSRPFGDGALKDKPLAVIGGAFGRYGGVWAHDETRKSFGIAGARVVEALKLSVPFQTLEGKAPAEHAELTQNVRDVVGKLAAEVG
>NZ_AP022573.1|WP_085255004.1|5538706_5539315_-|TetR/AcrR-family-transcriptional-regulator
MSHPAHGLHVCAPRAAQRERGDAARNRALLLDAARNLVAERGADAVTMDDIAAAAGVGKGTLFRRFGSRAGLMMVLLDEDERASQQAFLFGPPPLGPDAPPLDRLVAFGRDRIRFVHAHHALLSSVNNDPQSRYNAPAMVQRTHVRVLLQEAHTTGDLEAQTEALLALLDVDYVEHQLDEGGHTLQSLGDAFESVARKLCGH
>NZ_AP022573.1|WP_085255005.1|5537672_5538707_-|DNA-polymerase-IV
MAGAWVLHVDLDQFLASVELRRHPDLAGLPVIVGGSGNPTEPRKVVTCASYEAREFGVHAGMPLRAAARRCPGATFLPSDPPAYDAASQQVMGLLRDLGHPVEVWGWDEAYVGASVDDPVRLAEQIRAVVSSETGLSCSVGISDNKQRAKVATGFAKPAGIFALTDANWMTLMADRPVDALWSVGPKTAKKLAGIGITTVRELAYADAELLTATFGPRTGLWLLLLAKGGGDTEVSAEPWVPRSRSHVVTFPHDLTDRAEMDAAVTELARQALEEVMAAGRLVTRVAITVRTATFYTRTKIRKLDAPTTDRDVITAAALRVLDLFELDRPVRLLGVRLELAMPD
>NZ_AP022573.1|WP_085255006.1|5536805_5537738_+|SDR-family-oxidoreductase
MAPKDSGRYFAGKRCLVTGAASGIGRATALRLAAQGAELYLTDRNADGLRQTVADARALGADVPEHRALDIADYDEVAAFAADIHAGHPSMDVVLNIAGVSAWGTVDRLSHEQWTKMIAINLMGPIHVIETFVPAMVAAGRGGHLVNVSSAAGLVALPWHAAYSASKYGLRGLSEVLRFDLARHRIGVSLVVPGAVNTPLVNTVEIAGVDREDPKVARWVNRFTGHAVSPEKAADKILAGIARNRYLIYTSPDIWALYAFKRLAWWPYSVAMRQVNVIFTRALRPAPAPLVRHGQLEAHPQQPDRAVELE
>NZ_AP022573.1|WP_085255007.1|5536130_5536778_+|TetR/AcrR-family-transcriptional-regulator
MSSHAASPEPVIRRRGDKQRQAILQAVRELLQEKPFAELSVSTISLRAGVARSGFYFYFDSKYAVLAQILAEAAEELEELTHYFAPRQPGESPEQFAKRMVRSAAAVYSHNDPVVAACNAARHTDAEIRNILERQFEAVLRQIVAVVDAEMKAGTAAPISDDIPTLVRTLAGTTSLMLTGDPLLVGPQGLRVDVERRVRVLEQLWLHALWGGGAG
>NZ_AP022573.1|WP_085255008.1|5534522_5536004_-|cytochrome-P450
MAATISTPHYLLDQARRRLTPSFNNFPGMGVVERRLLNTTFPEHKLADPPPGSGLKPVMGDAGLPVIGHIIEMLRGGPDYLMFLYQTKGPVVFGDSPVLPGVAALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFKRGLMLLDFEEHMFHRRIMQEAFVRSRLVSYVEQMDQVVSQTVASDWVINDARFLLYPAMKELTLDIASMVFMGHEPGTDRELVTKVNKAFAVTTRAGNAIIRTPVPPFTWWRGLKARELLENYFRERVKEQRGKDGNDLLSALCHTEDEDGNSFSDEDIVNHMIFLMMAAHDTSTSTATTMVYQLAAHPEWQERCRDESDRLGDGPLDIESLEKLESLDLVMNESIRLVTPVQWAMRRTVRDTDLLGYYIPKGTNVIAYPGMNHRLPELWTDPMTFDPERFTEPRNEHKRHRYAFTPFGGGAHKCIGMVFGQLEIKTILHRLLRRYRLELPHAGYQAEWDYGGMPVPKDGMPIVLRPL
>NZ_AP022573.1|WP_085255009.1|5533990_5534512_+|homocitrate-synthase
MTLTSPDFDTVNVDSPRRTAADWFADHFGVALPRGLREGAGDLTWDAFVAAYAPTSGPIRLGHWACTDPDRPAGRLGPQARNFRAVIAVGDRIATSTAAAGGPVAALTAMLHERGFTLETLKFHQVRSAGCTATFIHGSNGIRAEWAMGVADDATQSALRAVIACANRLAGAA
>NZ_AP022573.1|WP_085255010.1|5532508_5533477_+|sensor-histidine-kinase
MTAGTQTEGPGFVHSALLYSSEQEFLDSVERFVVDGLAMDEAVLVAVPGDELALLHDALHSGGGLLDDVRMTDITEVARNPTRFMAMQGSFADSHPGRRVRIVSQLAWPGRTDGELAACVEHEALVNGALDGYQATGLCLYDASRLGDGVLADARATHPLLWSCGSLQPSDEYAPRDVLERCNRPLPANPGAVTYLVRSSGDLSPARSFAVRYAGWIGLSRAGIEDLQLIATELATNSLMYTDGACRLAFWREDEHLVCEARDTGRFDDPLVGRLDPGPSGPASRGLFLVNAISDLVRTHTTATGTTIQAYLRVDPSPAPNG
>NZ_AP022573.1|WP_085255166.1|5530928_5532377_+|FadR-family-transcriptional-regulator
MEPGTSARPQAGRADKLASTVARRIEADIVRRGWTVGESLGSEQALQQRYGVSRSVLREAVRLVEHHQVARMRRGPGGGLLICEPDAAPATRAVVIYLEYLGTTLDDLLNARLVLEPLAAALAAERIDEAGIDRLRAVLRAEEHWRPGLPAPRDGFHVALAERSKNPVLQLFIEILMRLTTRYALQSRTESATEAIEAVDHMHSDHTAIVAAVTAGDAARAKTLTERHVEAVTAWLREHHPGSRARVQRAPRRHDMGPRGKLAELLAASIGDDIAAGGWQVGSVFGTETALIERYRVSRSVFREAVRLLEYHSIARMRRGPGGGLVVTKPEAQASIDTIALYLQYRSPSREDLSCVRDAIEIDNVAKVVRRRTEAEVATFLGNHRSTDAVGDVRKAGVDEFLFHVGLAQLAGNALLDLFLRIIVELFRRHWSSTGQALPTPDDAAAVEHAHTRIVEAIEAGDDSLARHRIRRHLDAAASWWV
>NZ_AP022573.1|WP_085255000.1|5541310_5543476_+|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha
MPPTVAAEPVTSGAHALPGETDYHALNAMLNLYDADGKIQFDKDVLAAREYFLQHVNQNTVFFHNYDEKLDYLIRENYYEREVLDQYSRNFVKSLVERAYAKKFRFPTFLGAFKYYTSYTLKTFDGKRYLERFEDRVCMVALTLAAGDTGLAEKLVDEIIEGRFQPATPTFLNSGKKQRGEPVSCFLLRIEDNMESIGRSINSALQLSKRGGGVALLLSNIREHGAPIKNIENQSSGVIPIMKLLEDSFSYANQLGARQGAGAVYLHAHHPDIYRFLDTKRENADEKIRIKTLSLGVVIPDITFELAKKNEDMYLFSPYDVERVYGVPFADISVTEKYYEMLDDARIRKTKIKAREFFQTLAELQFESGYPYIMFEDTVNRANPIEGKITHSNLCSEILQVSTPSLFNEDLSYAKVGKDISCNLGSMNIAKTMDSPDFAHTIEVAIRGLTAVSDQTHISSVPSIEHGNNESHAIGLGQMNLHGYLAREHIFYGSEEGIDFTNIYFYTVLYHALRASNRIAIERGTHFTGFEKSKYASGEFFDKYTEQVWEPKTDKVRQLFADADIRIPTQDDWRRLKESVRAHGIYNQNLQAVPPTGSISYINHSTSSIHPIVSKVEIRKEGKIGRVYYPAPYMTNENLEYYQDAYEIGYEKIIDTYAAATQHVDQGLSLTLFFKDTATTRDVNKAQIYAWRKGIKTLYYIRLRQMALEGTEVEGCVSCML
>NZ_AP022573.1|WP_142280521.1|5543614_5544358_+|TetR-family-transcriptional-regulator
MVRIPRPPHPSVKPGVKVDARSERWREHRKKVRGEIVDAAFRAIDRLGPELSVREIAEEAGTAKPKIYRHFQDKSDLFQAIGERLRDMLWGAIFPSIDLKTDSAREVIRRAVEEYVNLVDQHPNVLRVFIQGQSSATPQSAVQILNEGRGITLAVADMFDNELKEMELDHAAIELAGHAAFGSAASATEWWLGPDPDSPRRMPHERFVAHLTTIMIGVIVGTAEALGIALDPDLPIHSVVPHNSATG
>NZ_AP022573.1|WP_085255164.1|5544414_5545974_-|MFS-transporter
MTAPELAGERQHRAPGRHGIRGNPWWTLAAASIGVIMVGLDASVVAIANPRIAIDLHASLQDLQWITDAYMLALASLLIFGGKLADRFGRRRAFFVGVVGFAVTSVGIGLIGTVGGVITLRALQGVFGALLMPATLAIVRAAFPPEKLNTAIGIWGGASGVSIAAGPIVGGLLVEHVNWQSVFYINAPIAALALLVGGLAIAESRSAGGRRLDIPGTVTLSGGLFLVVFGLIKAQNWGWLAGRTLGLLFAGLAAVAAFVLIELRTAEPLLPMRLFANRQLSIGTAVVVIDFFALFGAVFFLSLYLQNVLGFSPVETGVRTLPLSLTLMVTAPLSGFLTEKFGPRPSMVLGLAAVSAALFSLDFLRTDSGYGALWPAFVLLGAGIGLVLTASSEAIMGNAGDDDAGVAGGLQSTAIQLGGVLGTTVLGSVLSSRVGYVLVDQLTGAGVPAPVAGKLTAAKELVAQGFSPTVPGMPAPLAHAVTQGSHGAFMVGLHASMVVAAVAAAVGAVLAMFVGRGTK
>NZ_AP022573.1|WP_085255163.1|5546162_5546750_+|helix-turn-helix-transcriptional-regulator
MSAAAELFAERGLSVPLEEIAARAGVGVATLYRRFPTRADLAAAAFERNIAGYTRAVDRALANHDAWEGFRGLVFELCEMQAADAGLRDLLTTAFPASSAVEQRTNEAVEKVRTLIGRAQSAGVLRPDVVAGDIVVMLLANAGVLRATGASAPDAWRRFAALMVDAFRARPGPPLPPAPPEQQLRRSVALLTEGR
>NZ_AP022573.1|WP_085254999.1|5546850_5548422_+|NAD(P)/FAD-dependent-oxidoreductase
MTIAEASAEPGADQGPASQAHQPVHTRALIIGTGFSGLGMAIKLQQQGVDFVILEKAGDIGGTWRDNSYPGCACDIPSHLYSFSFEPKPDWKNPFSYQPEIWDYLKGVTEKYGLRRYIVFNSLVDRGHWDDDECRWHVFTSDGREYVAQFLISGAGALHIPSIPDFEGRDEFRGPAFHSAEWDHSVDLTGKRVAVIGTGASAIQIVPEIVGQVAELQLYQRTPAWVVPRSNPEIPVALRRAMENVPGLRALTRLGIYWGQEALAFGMTKRPNLLKIIEAYAKYNIRRSIKDRDLRRKLTPHYRLGCKRILNSSTYYPAIANPKTKLITDRITRITPDGIVTADGTEHKVDVIVYGTGFHVTDSYTYVQIKGLHGEDLVDRWNREGIGAHRGITVADVPNLFFLLGPNTGLGHNSVVFMIESQIHYVADAIAKCDRMGAQGLAPTRVAQDRFNNELQEHLSHSVWNSGGCSSWYLDEHGRNTVLWGGYTWQYWMATRSVKPEEYQFFGVGKGSRADRSAVAAQA
>NZ_AP022573.1|WP_085255162.1|5548412_5549330_-|SDR-family-NAD(P)-dependent-oxidoreductase
MSTRNSADRHELIVVSGASTGIGAATARELARRGFHVLAGVRREQDAEALRAERIEPQILDITVESDIAAIADRVASDPQHRPLRALVNNAGIAVNAPFEALPLAQWRRQFEVNLFGHIAITQALFPALLNGAGTVVNISSIGGKVVLPTYGAYAGSKFALEAVSDALRREVIGTGIRIVVVEPGAVKTTMPERGIATALELQADMTAAQRARYGDLIAASTAQARSFCATGVSADHAAKVIAKAATASRPRTRYTIGRDAAVLARISRIVSDRVLDRIVARELRRFRDGDQSRAPRNTVGAVQA
>NZ_AP022573.1|WP_085254998.1|5549422_5549995_+|helix-turn-helix-transcriptional-regulator
MATRAERAAATRRSLLAAAGVLLDLGGVEAVTLREVGARSGVSRSAAYRHFADKEALLAVLATNALAELGDALEGLVASGDPPEVSLRSGLLSLIAIGRARPHLYRLMFTPPAGDPIEAARAAERTQNLFLELVGRIVGPGQARRYGAVLLTSAHGITGLDLSGHMDLDKWHTNAEELVDTLISLLPRAK
>NZ_AP022573.1|WP_085254997.1|5549971_5550520_-|TetR/AcrR-family-transcriptional-regulator
MARTPDLERRRQLLAAVVEEFATGGVGDRSLRDVAAAVGTSHRMLLHHFGSRGDLLVAIVEEVERRQMRLLPELPADPAASFAAMWADVRRPELRNSERLFFECYARAAQGEKPYARMVPDAVNGWLAEVEAAAGAPVDPAMARLGLAVIRGLLLDLVATDDDAGVDAAALLFAELLRSRQQ
>NZ_AP022573.1|WP_085254996.1|5550503_5550950_-|SRPBCC-family-protein
MITDDSVEIDAPATLVWEVFTDVERWPQWTASVTSLAAVDGPGLAVGKRFAIKQPRMPKLVWTVTAIDPGTSWTWEVRSPGASTSARHQVISQPGGRTLVTQRLDQGGPVGGLVGRLTSAMTKRYLAMEARGLKARSEQLSRTGGAHP
>NZ_AP022573.1|WP_085254995.1|5551192_5552569_+|HNH-endonuclease
MASSGGVSQEALAAAFDTIDAAMDKGVGIDCDAFSTQDALAFLERSERVRRRLPALEHPLINLLGRQATPEELGGKLSHAIAEAARISRAEASRRVKDAVDLGPRRGLTGERLDPVLAHTAAAQRDGALGPEHVGVIRKFFRHLPRCIDQQIREQVEDRLAVEGARYRPEQLGELGAVLADCLNPDGNYTDADRALRRGLTLGPQGADGMSELRGRLTPEARATLEAVMAKLGAPGMCNPLDDNPCVDGNPSQEAIDTDARGTAQRQHDALLAGLRALLASGKLGRHNGLPASIIVTTTLAELEAAAGRGLTGGGSIVPMSDVIRLSRHARHYLAIFDKGKALALYHAKRLASPGQRIVLYAKDRGCSAPGCTVPGYYSEVHHVTDYAQCRHTDVNELTFACGPQHRLIKPGGWSTRKNANGETEWIPPPHLDRGQPRINTFHHPEKLLRDGDDEDGC

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Crispr_ID: NZ_AP022573_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022573_6

5637447-5637530

Orphan

Consensus_repeat	Method
CTGATGGCGGTGACCCGCATCGCCCGGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022573_6

>merge|NZ_AP022573|6|5637447-5637530|CRISPRCasFinder
CTGATGGCGGTGACCCGCATCGCCCGGCACCGCCGGGCTCGCGATCACCGCTGGGCTGATGGCGGTGACCCGCGTCGCCCGGCA

>NZ_AP022573|6|6|5637447-5637530|CRISPRCasFinder
CTGATGGCGGTGACCCGCATCGCCCGGCA	CCGCCGGGCTCGCGATCACCGCTGGG
CTGATGGCGGTGACCCGCGTCGCCCGGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022573.1\|WP_085256201.1\|5645588_5647814_+\|ATP-dependent-DNA-helicase-RecG	unknown	unknown	gnl\|CDD\|236794
NZ_AP022573.1\|WP_085256192.1\|5637624_5638644_+\|NAD(P)-dependent-glycerol-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|234629
NZ_AP022573.1\|WP_085256194.1\|5639826_5640399_-\|DUF3515-domain-containing-protein	unknown	unknown	gnl\|CDD\|378794
NZ_AP022573.1\|WP_085256310.1\|5636750_5637401_-\|2-phospho-L-lactate-guanylyltransferase	unknown	unknown	gnl\|CDD\|224831
NZ_AP022573.1\|WP_085256185.1\|5628696_5629209_-\|PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274679
NZ_AP022573.1\|WP_085256186.1\|5629538_5630240_-\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_AP022573.1\|WP_085256197.1\|5642217_5642748_+\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176191
NZ_AP022573.1\|WP_085256193.1\|5638711_5639830_+\|D-alanine--D-alanine-ligase	unknown	unknown	gnl\|CDD\|234993
NZ_AP022573.1\|WP_085256183.1\|5626062_5626860_+\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223257
NZ_AP022573.1\|WP_085256189.1\|5632585_5633221_+\|HU-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|223847
NZ_AP022573.1\|WP_085256190.1\|5633285_5634227_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239645
NZ_AP022573.1\|WP_085256191.1\|5634312_5636502_-\|RNA-degradosome-polyphosphate-kinase	unknown	unknown	gnl\|CDD\|235469
NZ_AP022573.1\|WP_085256198.1\|5642780_5643431_+\|nitroreductase	unknown	unknown	gnl\|CDD\|380313
NZ_AP022573.1\|WP_085256199.1\|5643441_5643636_-\|50S-ribosomal-protein-L28	unknown	unknown	gnl\|CDD\|234736
NZ_AP022573.1\|WP_085256187.1\|5630307_5631756_+\|3-isopropylmalate-dehydratase-large-subunit	unknown	unknown	gnl\|CDD\|235490
NZ_AP022573.1\|WP_085256188.1\|5631774_5632371_+\|3-isopropylmalate-dehydratase-small-subunit	unknown	unknown	gnl\|CDD\|179314
NZ_AP022573.1\|WP_085256184.1\|5626856_5628323_+\|glutamate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234953
NZ_AP022573.1\|WP_085256200.1\|5643903_5645586_+\|DAK2-domain-containing-protein	unknown	unknown	gnl\|CDD\|274671
NZ_AP022573.1\|WP_085256195.1\|5640518_5641487_+\|thiamine-phosphate-kinase	unknown	unknown	gnl\|CDD\|235583
NZ_AP022573.1\|WP_085256196.1\|5641528_5642212_+\|uracil-DNA-glycosylase	unknown	unknown	gnl\|CDD\|235376

Protein	Function_ID	Function_description	E-value
NZ_AP022573.1\|WP_085256201.1\|5645588_5647814_+\|ATP-dependent-DNA-helicase-RecG	gnl\|CDD\|236794	PRK10917, PRK10917, ATP-dependent DNA helicase RecG; Provisional.	0
NZ_AP022573.1\|WP_085256192.1\|5637624_5638644_+\|NAD(P)-dependent-glycerol-3-phosphate-dehydrogenase	gnl\|CDD\|234629	PRK00094, gpsA, NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.	1.1282e-160
NZ_AP022573.1\|WP_085256194.1\|5639826_5640399_-\|DUF3515-domain-containing-protein	gnl\|CDD\|378794	pfam12028, DUF3515, Protein of unknown function (DUF3515). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 166 to 214 amino acids in length. This protein has a conserved RCG sequence motif.	5.54573e-48
NZ_AP022573.1\|WP_085256310.1\|5636750_5637401_-\|2-phospho-L-lactate-guanylyltransferase	gnl\|CDD\|224831	COG1920, COG1920, Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only].	3.13414e-58
NZ_AP022573.1\|WP_085256185.1\|5628696_5629209_-\|PPOX-class-F420-dependent-oxidoreductase	gnl\|CDD\|274679	TIGR03618, Rv1155_F420, PPOX class probable F420-dependent enzyme. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity].	1.06973e-29
NZ_AP022573.1\|WP_085256186.1\|5629538_5630240_-\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	5.047e-53
NZ_AP022573.1\|WP_085256197.1\|5642217_5642748_+\|zinc-binding-dehydrogenase	gnl\|CDD\|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	2.79846e-28
NZ_AP022573.1\|WP_085256193.1\|5638711_5639830_+\|D-alanine--D-alanine-ligase	gnl\|CDD\|234993	PRK01966, ddl, D-alanine--D-alanine ligase.	0
NZ_AP022573.1\|WP_085256183.1\|5626062_5626860_+\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	7.50969e-109
NZ_AP022573.1\|WP_085256189.1\|5632585_5633221_+\|HU-family-DNA-binding-protein	gnl\|CDD\|223847	COG0776, HimA, Bacterial nucleoid DNA-binding protein [DNA replication, recombination, and repair].	4.08242e-25
NZ_AP022573.1\|WP_085256190.1\|5633285_5634227_-\|NUDIX-hydrolase	gnl\|CDD\|239645	cd03673, Ap6A_hydrolase, Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most preferred substrate, hydrolyzes to produce two ATP molecules, which is a novel hydrolysis mode for Ap6A. These results indicate that Ap6A hydrolase is a diadenosine polyphosphate hydrolase. It requires the presence of a divalent cation, such as Mn2+, Mg2+, Zn2+, and Co2+, for activity. Members of the Nudix superfamily are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site.	8.29202e-50
NZ_AP022573.1\|WP_085256191.1\|5634312_5636502_-\|RNA-degradosome-polyphosphate-kinase	gnl\|CDD\|235469	PRK05443, PRK05443, polyphosphate kinase; Provisional.	0
NZ_AP022573.1\|WP_085256198.1\|5642780_5643431_+\|nitroreductase	gnl\|CDD\|380313	cd02136, PnbA_NfnB-like, nitroreductase similar to Mycobacterium smegmatis NfnB. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.	1.94804e-47
NZ_AP022573.1\|WP_085256199.1\|5643441_5643636_-\|50S-ribosomal-protein-L28	gnl\|CDD\|234736	PRK00359, rpmB, 50S ribosomal protein L28; Reviewed.	1.98143e-24
NZ_AP022573.1\|WP_085256187.1\|5630307_5631756_+\|3-isopropylmalate-dehydratase-large-subunit	gnl\|CDD\|235490	PRK05478, PRK05478, 3-isopropylmalate dehydratase large subunit.	0
NZ_AP022573.1\|WP_085256188.1\|5631774_5632371_+\|3-isopropylmalate-dehydratase-small-subunit	gnl\|CDD\|179314	PRK01641, leuD, 3-isopropylmalate dehydratase small subunit.	1.5195e-114
NZ_AP022573.1\|WP_085256184.1\|5626856_5628323_+\|glutamate--tRNA-ligase	gnl\|CDD\|234953	PRK01406, gltX, glutamyl-tRNA synthetase; Reviewed.	0
NZ_AP022573.1\|WP_085256200.1\|5643903_5645586_+\|DAK2-domain-containing-protein	gnl\|CDD\|274671	TIGR03599, YloV, DAK2 domain fusion protein YloV. This model describes a protein family that contains an N-terminal DAK2 domain (pfam02734), so named because of similarity to the dihydroxyacetone kinase family family. The GTP-binding protein CgtA (a member of the obg family) is a bacterial GTPase associated with ribosome biogenesis, and it has a characteristic extension (TIGR03595) in certain lineages. This protein family described here was found, by the method of partial phylognetic profiling, to have a phylogenetic distribution strongly correlated to that of TIGR03595. This correlation implies some form of functional coupling.	2.23332e-174
NZ_AP022573.1\|WP_085256195.1\|5640518_5641487_+\|thiamine-phosphate-kinase	gnl\|CDD\|235583	PRK05731, PRK05731, thiamine monophosphate kinase; Provisional.	6.7944e-117
NZ_AP022573.1\|WP_085256196.1\|5641528_5642212_+\|uracil-DNA-glycosylase	gnl\|CDD\|235376	PRK05254, PRK05254, uracil-DNA glycosylase; Provisional.	7.16697e-129

>NZ_AP022573.1|WP_085256310.1|5636750_5637401_-|2-phospho-L-lactate-guanylyltransferase
MSGTRAGGAGEVALIIAVKRLAAAKTRLAPVFSPRTRESVVLAMLVDTLTAASRVRAVGSITVITPDAAAAAAAAELGAEVLDDPTPEGHNDPLNNAIGAAERSVADSFANFVVLQGDLPALQSQELAEAIGAARQHRRSFVADRLATGTSALCAFGTALDPHFGADSAARHRHSGAIELTGAWPGLRCDVDTPADLAAARQLGVGPATARTLAHH
>NZ_AP022573.1|WP_085256191.1|5634312_5636502_-|RNA-degradosome-polyphosphate-kinase
MRNDRSVTDIEAEARPDENIWHPGDSTLTAPPAATPAAITDQLPEERYLNRELSWLDFNARVLALAADNSLPLLERAKFLAIFASNLDEFYMVRVAGLKRRDEMGLSVRSADGLTPREQLALIGEQTQRIATRHARVFLDAVRPALAEEGIHIVTWADLDHAEQDELSTYFTEQVFPVLTPLAVDPAHPFPFVSGLSLNLAVMVRQPEDGGQHFARVKVPNNVDRFVELESRRVADDGEGPAVVRYLPMEELIAAFLPVLFPGMEIVEHHAFRITRNADYEVEEDRDEDLLQALERELARRRFGSPVRLEIADDMTESMLELLLRELDVNPGDVIEVPGLLDLSSLWQIYGIDRPALKDVAWVPDTHPAFADRETPRSIFATLREGDVLLHHPYDSFSTSVQRFIELAAADPNVLAIKQTLYRTSGDSPIVRALIAAAEAGKQVVAMVEIKARFDEQANIRWARTLEQAGVHVVYGYVGLKTHCKTCLVVRREGSTIRRYCHIGTGNYNGKTARLYEDVGLLTASPEIGADLTDLFNSLTGYSRKVSYRNLLVAPHSIRTGIIERVEREVAAHRENGGGRIRMKMNALVDEQVIDALYRASQAGVRVEVVVRGICALRPGAEGYSENISVRSILGRFLEHSRIMHFNCLNEFWIGSADMMHRNLDRRVEALVQVKDPRLTAYLNDLFESALDPATRCWELRADGQWTASPQDGQTVRDHQVSLMERHRS
>NZ_AP022573.1|WP_085256190.1|5633285_5634227_-|NUDIX-hydrolase
MPNQDSSASRRSGSRIVYAAGAVLWRPTVSANPGLEIAVIHRPRYDDWSLPKGKVDPGETAPVAAVREVLEETGHQATLGRRLDMVSYPIDQGVKKVYYWAARSNGGEFHPGKEVDELIWLPADEAMRRLDYPQDRKMLGHFAKHPADTKTVLVVRHGTAGSKSRFSGDDTKRPLDKRGRAQAEALVPQLLSFGASEVYAADRLRCHQTVQPLAEELGVAIHNEPTLTEEAYAKSPKRGRQRVLQIAERGGTPVICTQGKVIPDLIEWWCGRDGVQPDKSRNNKGSTWVLSLAAGRLLAADHIGGALAANVRA
>NZ_AP022573.1|WP_085256189.1|5632585_5633221_+|HU-family-DNA-binding-protein
MNKAELIDVLTQKLGSDRRQATAAVENVVDTIVRAVHKGDSVTITGFGVFEQRRRAARVARNPRTGETVKVKPTSVPAFRPGAQFKAVVAGAQRLPAEGPAVKRGVGAGAAKKVAKKAPAKKAASKAPAKKAATKAPAKKVATKAPAKKVAPAKKAVTKAPAKKAVTKAPAKKAAPAKKAATKAPAKKAATKAPAKKAPAKKTTTARRGRR
>NZ_AP022573.1|WP_085256188.1|5631774_5632371_+|3-isopropylmalate-dehydratase-small-subunit
MEAFRTHTGIGVPLRRSNVDTDQIIPAVYLKRVTRTGFEDGLFATWRSDPSFVLNLSPFDRGSVLVAGPDFGTGSSREHAVWALMDFGFRVVISSRFGDIFRGNAGKAGLLAAEVSQDGVELLWKLIEQSPGLEITVNLQDRNITAGTAVLPFRIDDHTAWRLLEGLDDIALTLRKLDKIESFEAARPEWKPRTLPAS
>NZ_AP022573.1|WP_085256187.1|5630307_5631756_+|3-isopropylmalate-dehydratase-large-subunit
MGSDTTGAGKPRTLAEKVWSDHVVASGGGSEQGGAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTLATEDHNVPTVDIDKPIADPVSRTQVETLRHNCAEFGIRLYPMGDIEQGIVHVVGPQLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVEGRLPAGVTAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDETTYEYLRGRPHAPTGAQWDEAMAYWQQLRTDDGAEFDTDVYLDATELSPFVTWGTNPGQGVPLSAAVPDPELIADDGERQAAEKALAYMDLRPGTPMREVGVDAVFVGSCTNGRIEDLRAVADVLRGRKVAPGVRMLVVPGSMRVRAQAEAEGLGEIFTAAGAEWRQAGCSMCLGMNPDQLAPGERCAATSNRNFEGRQGKGSRTHLVSPVVAAATAVRGKLSAPADLNSH
>NZ_AP022573.1|WP_085256186.1|5629538_5630240_-|IclR-family-transcriptional-regulator
MRQHSGIGVLDKAMVVLHTIAESPCGLAELCERTGLPRATAYRLAAALEVHRLLARDDDGRWRLGPAVSELAIQVNDPLLAAGAAVLPLLRETTGESVQLYRREGTSRVCIAALEPAVGLRDTVPVGARLPMTAGSGAKVLLAYSDAATQKAVLPSAKFTDRVLADVRRRGWAQSVAEREPGVASVSAPVRDGRGAVIAAISVSGPIDRIGRRPGVRWAADLLNASEALTRRL
>NZ_AP022573.1|WP_085256185.1|5628696_5629209_-|PPOX-class-F420-dependent-oxidoreductase
MGTNQRASIVMSEDEIADFVVRSRTGTLATVGIDGQPHLTAMWYAVVDGEIWLETKAKSQKAVNLKRDPRVSFLIEDGDTYDTLRGVSFEGIAEIIDDPEVAHRVGVSVFERYTGPYSDEMKPFVEQMMNKRVCVRIVPRRARSWDHHKLGLPPMPVGGSTAPAARAADQ
>NZ_AP022573.1|WP_085256184.1|5626856_5628323_+|glutamate--tRNA-ligase
MTTAGQVRVRFCPSPTGTPHVGMVRTALFNWAYARHTGGTFVFRIEDTDAERDSEESYLALLDALRWLGLDWDEGPEVGGPYGPYRQSQRKEVYREVVAKLLEAGEAYYAFSTPEEVEARHIAAGRNPKLGYDNFDRQLTDPQRAAFLAEGRKPVVRLRMPDEDLAWDDLVRGTTTFAAGSVPDFALTRANGDPLYTLVNPVDDALMKITHVLRGEDLLPSTPRQLALYQSLIRIGVAERTPQFAHLPTVLGEGTKKLSKRDPQSNLFAHRDRGFIPEGLLNYLALLGWAIADDHDLFSLDEMVAAFDVVDVNSNPARFDQKKADALNAEHIRMLEPADFAGRLRDYFDAHGHRLGLDDAAFATAADLVQTRIVVLGDAWELLKFLNEDEYAIDPKAAGKELGPDAGPVLDAALAALDGLAEWTTAHIETALKTALIDDLALKPRKAFGPIRVAATGTTVSPPLFESLELLGRVRSLRRLSAAREAIV
>NZ_AP022573.1|WP_085256183.1|5626062_5626860_+|fumarylacetoacetate-hydrolase-family-protein
MRLGRIASPDGVAFVSIEGDTADPAGMTAREIAEHPFGTPSFTGRSWPLADVRLLAPILAGKVVCVGKNYADHVAEMSNLTGPAPADPVIFLKPNTAIVGPNAPIKLPANASPVHFEGELAAVIGRPCKDVAAAQAAENILGYTIANDVSARDQQKADGQWTRAKGHDTFCPVGPWIVTDVDPADLELRTEVNGEVKQNSRTSLMIHDVGDIIEWISAVMTLLPGDLILTGTPAGVGPIEDGDTVSITIEGIGTLSNPVVRKGKS
>NZ_AP022573.1|WP_085256192.1|5637624_5638644_+|NAD(P)-dependent-glycerol-3-phosphate-dehydrogenase
MAGTSGAVAVMGAGAWGTALAKVLVDAGGPETAVKLWARRPDIADEINSTRYNPDYLPGTLLPAGIRATSDPGEALSGATTVLLGVPAQTLRANLERWVSALTEGATLVSLAKGIELETLMRMSQVIVSVTDVEPDHVAVISGPNLASEIAGGQPAATVIACNDSGRAVALQRMLNSGYFRPYTNSDLIGTEIGGACKNVIALACGMAAGVGLGENTAAAIITRGLAEIMRLGIALGAKAATLAGLAGVGDLVATCTSPYSRNRSFGECLGRGGTMESAMQARDGHVVEGVTSCESVLALALSYDVEMPLTDAVHRVCHKGLSVDEAMALLLGRRTKPE
>NZ_AP022573.1|WP_085256193.1|5638711_5639830_+|D-alanine--D-alanine-ligase
MSASDRSNRVRVAVVFGGRSNEHAISCVSAGSILRNLDPERFEVVAVGITPEGAWVLTDGDPDALAITNRQLPAVTAQSGRELALPADPGRSGQLVALQPGAGEVLASVDVVFPVLHGPYGEDGTVQGLLELAGLPYVGAGVLASAAGMDKEFTKKLLAAEGLPVGPHIVLRPNRPTLHPEERERLGLPVFVKPARGGSSIGVSRVTSWDQLPAAVAAARRHDPKVIVEAAINGRELECGVLEMPDGSVEASTVGEIRVVGVRGREDSFYDFATKYLDDAAELDVPAKVDDEIADAVRQLAVLAFKAIDCQGLARVDFFLTEEGPVINEINTMPGFTTISMFPRMWAASGVDYPALLATMVETALARGVGLR
>NZ_AP022573.1|WP_085256194.1|5639826_5640399_-|DUF3515-domain-containing-protein
MPTDPDTGSKDDAGPPRAAVLAAVALAVVAVGVILAIAAGREAPRRPVDVAAIPAPQAASPACRSLAAALPQRLGDYQRVPIAAPVPPGTYAWRASADVGPVVLRCGLARPGEFVVGTPIQVVDKVQWFEASAERQSAGDAGTFTWYTVDRPVYVALTLPSGSGPTPIQQLSDVIDHAMPAVPIDPAPAR
>NZ_AP022573.1|WP_085256195.1|5640518_5641487_+|thiamine-phosphate-kinase
MDDDFSAQPPTLRQVGEFGVIDRLVRGRRQSAAVLLGPGDDGAVIAAGDGRAVVSTDMLVQDRHFRLDWSTPHDVGRKAIAQNAADIEAMGGRATAFVVAFGAPADTPAAQAEALVDGMWDEAGRVGAGIAGGDLVSCPQWVISVTVLGDLAGRAPVLRSGAKAGSVIAAAGELGRSAAGYWLWRKRIEGHDELRQRHLVPRPPYGQGAAAAAAGAEAMIDVSDGLIADLRHVADASGVGLDLSTAALVADRDALAPAAAAAGEDPWPWVLAGGEDHALVACFAGPVPTGWRPIGRVLDGPARVLVDGAEWAGYAGWQSFEG
>NZ_AP022573.1|WP_085256196.1|5641528_5642212_+|uracil-DNA-glycosylase
MTARPLSELVERGWATALEPVAGQVARMGEFLRTEIAAGHRYLPAGPNVLRAFTFPFDDVRVLIVGQDPYPTPGHAVGLSFSVAPEVRPLPRSLANIFDEYTTDLGHPQPSCGDLSPWAQRGVMLLNRVLTVRPSNPASHRGKGWEAVTECAIRALVARSQPLVAILWGRDASTLKPVLAEGNCVAIESPHPSPLSASRGFFGSRPFSRANKLLAEMGADPIDWRLP
>NZ_AP022573.1|WP_085256197.1|5642217_5642748_+|zinc-binding-dehydrogenase
MTALRAHHRGGPRELVVEPAPVPVPAPGEVLVAVHAAAITFDELTWEETWTRDGASRTPVIPSHEVSGVVHQIGTGVTDFAPGDEVYGLIPFDRDGAAAAASAPRPAGRADEYGVTATFFIVPPDRDQLTRLAALVDDGRLRVQIAATFPLGEGREAFESGQRPGRRPGKTVIVLE
>NZ_AP022573.1|WP_085256198.1|5642780_5643431_+|nitroreductase
MYDLDDTIRRRHSTRMFLPDPVPHHLVEESLELATRAPSNSNVRPWHVVFVSGAARDRLVAAMLEQARSEPPKVPQLPAEFAHLRRDLGAHVYGAMGIARDDAEARRVAVLRNWEFFRAPLGGVVSTHRDFGLVDSLGVGMFLQTLVLALTARGLGACVQVSIAGYPGIVREQLGIPEETTILCGLAVGYSDPDFPGNSLRVGRERVDRHAVFLDE
>NZ_AP022573.1|WP_085256199.1|5643441_5643636_-|50S-ribosomal-protein-L28
MAAVCDICGKGPGFGKSVSHSHRRTSRRWDPNVQTVHAATRPGGNKQRLNVCTSCIKAGKVVRG
>NZ_AP022573.1|WP_085256200.1|5643903_5645586_+|DAK2-domain-containing-protein
MDTSHRVLDAATLRDWAHTAVSDLITHIDEINRLNVFPVADADTGANMLFTMRSALAEANAGANTDGGPGCVARAAAALSAGALNGARGNSGVILSQILRGIADVTAAAAADSGGELGRIDAALLGAGLRRGVDLVIASMGGEEVPGTIVSVLRAAAEAVAECADEGLVAAVTAAGDAAVVALEKTTEQLDVLADAGAVDAGGRGLLVLLDALRSTISGQAPARTVYEIAPRQMPPHAPAERPAPQFEVMYRLDGCDPPAADALRDRLEELGDSVAIAAAPATDGTYSVHVHTDDAGAAVEAGLVAGRPSRIVISVLGSGGTGLPAGGWTRERAVLAVVDGDGAAELFAAEGANVLRPDVTAGHPATDISAHQLMRAVVDTGAAQVMVLPNGYVAAEELVAGCTAAIGWGIDVVPIPTGSMVQGLAALAVHETDRPAVDDGYTMARAAGAARHGSVRIATESALTWAGRCQPGDGLGIAGDEVLIVAADAVGAAIGLLDLLLASGGDLATVLVGAGFEADVDAEALGDILEEHMHDHHPGTELVTYRTGHRGDALLIGVE
>NZ_AP022573.1|WP_085256201.1|5645588_5647814_+|ATP-dependent-DNA-helicase-RecG
MASLGDRLDFVVGAKAADQLDEELGIRTVDDLLRHYPRSYTEGATRWDADGRRPPAGEHVTIVDTIAETKTWPMKKTPNKLCHRITLGAGRNKVTATFFNANYLKKDLVKGTKVMLSGEVGFFNNAMQLTHPAFLILDSPDGRDRGTSSLKNIAIASKASTGELQMSAFERAFFPIYPATTKLQSWDIFRCVRQVLDVLDPIDDPLPAGLRERHGLVSEDRALRDIHLAEDESARRRARQRLTFDEAVGLQWALVARRHSELSESGPPAPPRPEGLAAELLARLPFELTAGQREVFAVFAEELSATRPMNRLLQGEVGSGKTILAVLAMLQLVDAGYQCALLAPTEVLAAQHVRSINDVLGPLAMAGQLGGADTATRVALLTGSMTAAQKKQVRAEIAGGQVGIVVGTHALLQDAVEFDNLGMVVVDEQHRFGVEQRDQLRAKARPGVTPHLLVMTATPIPRTVALTVYGDLETSTLRELPRGRQPITSNVIFVRDKPAWLERAWRRITEEVAAGRQAYVVTPRIDETDDPEKEKQEQNVKPSETAEGLYARLRSGELADVRLGLMHGRLSADDKDAVMSAFRAGDIDVLVCTTVIEVGVDVPNATVMLVMDADRFGISQLHQLRGRIGRGRHPSLCLLASWVSPDSGAGERLRAVAETLDGFALADLDLKERREGDVLGRNQSGRAISLKLLSLADHLDVIDAARAFCVSAYEEDATNPGLAALAARFTSTDRIEYLDKA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP022573_6	6.1\|5637476\|26\|NZ_AP022573\|CRISPRCasFinder	5637476-5637501	26	NZ_CP029359	Azospirillum sp. CFH 70021 plasmid unnamed4	91638-91663	3	0.885
NZ_AP022573_6	6.1\|5637476\|26\|NZ_AP022573\|CRISPRCasFinder	5637476-5637501	26	NZ_CP016083	Streptomyces sp. SAT1 plasmid unnamed3, complete sequence	387192-387217	4	0.846
NZ_AP022573_6	6.1\|5637476\|26\|NZ_AP022573\|CRISPRCasFinder	5637476-5637501	26	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	1274650-1274675	4	0.846
NZ_AP022573_6	6.1\|5637476\|26\|NZ_AP022573\|CRISPRCasFinder	5637476-5637501	26	NZ_CP015735	Arthrobacter sp. U41 plasmid unnamed3, complete sequence	33368-33393	4	0.846
NZ_AP022573_6	6.1\|5637476\|26\|NZ_AP022573\|CRISPRCasFinder	5637476-5637501	26	NZ_CP047899	Pseudarthrobacter sp. YJ56 plasmid unnamed1, complete sequence	82634-82659	4	0.846
NZ_AP022573_2	2.1\|1046305\|28\|NZ_AP022573\|CRISPRCasFinder	1046305-1046332	28	NC_012811	Methylorubrum extorquens AM1 megaplasmid, complete sequence	1235329-1235356	5	0.821
NZ_AP022573_2	2.1\|1046305\|28\|NZ_AP022573\|CRISPRCasFinder	1046305-1046332	28	NZ_CP025613	Niveispirillum cyanobacteriorum strain TH16 plasmid unnamed1, complete sequence	906486-906513	5	0.821
NZ_AP022573_2	2.1\|1046305\|28\|NZ_AP022573\|CRISPRCasFinder	1046305-1046332	28	NZ_CP021084	Deinococcus ficus strain CC-FR2-10 plasmid pDFI3, complete sequence	112390-112417	5	0.821
NZ_AP022573_2	2.1\|1046305\|28\|NZ_AP022573\|CRISPRCasFinder	1046305-1046332	28	MT491207	Pseudomonas phage vB_PaeM_USP_18, complete genome	3836-3863	5	0.821
NZ_AP022573_6	6.1\|5637476\|26\|NZ_AP022573\|CRISPRCasFinder	5637476-5637501	26	NZ_CP012265	Cronobacter condimenti 1330 strain LMG 26250 plasmid pCCO1, complete sequence	60652-60677	5	0.808
NZ_AP022573_6	6.1\|5637476\|26\|NZ_AP022573\|CRISPRCasFinder	5637476-5637501	26	NZ_CP022991	Paraburkholderia aromaticivorans strain BN5 plasmid pBN1, complete sequence	266567-266592	5	0.808
NZ_AP022573_6	6.1\|5637476\|26\|NZ_AP022573\|CRISPRCasFinder	5637476-5637501	26	NZ_CP007130	Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence	976281-976306	5	0.808
NZ_AP022573_6	6.1\|5637476\|26\|NZ_AP022573\|CRISPRCasFinder	5637476-5637501	26	MK279848	Gordonia phage Dorito, complete genome	20887-20912	5	0.808
NZ_AP022573_2	2.1\|1046305\|28\|NZ_AP022573\|CRISPRCasFinder	1046305-1046332	28	NZ_CP040720	Rhodococcus pyridinivorans strain YF3 plasmid unnamed1, complete sequence	183875-183902	6	0.786
NZ_AP022573_2	2.1\|1046305\|28\|NZ_AP022573\|CRISPRCasFinder	1046305-1046332	28	NZ_CP050083	Rhizobium leguminosarum bv. trifolii strain 31B plasmid pRL31b3, complete sequence	470165-470192	6	0.786
NZ_AP022573_2	2.1\|1046305\|28\|NZ_AP022573\|CRISPRCasFinder	1046305-1046332	28	NZ_CP050100	Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b3, complete sequence	139323-139350	6	0.786
NZ_AP022573_2	2.1\|1046305\|28\|NZ_AP022573\|CRISPRCasFinder	1046305-1046332	28	NC_008381	Rhizobium leguminosarum bv. viciae 3841 plasmid pRL10, complete sequence	342750-342777	6	0.786
NZ_AP022573_2	2.1\|1046305\|28\|NZ_AP022573\|CRISPRCasFinder	1046305-1046332	28	NZ_CP025017	Rhizobium leguminosarum strain Norway plasmid pRLN5, complete sequence	119579-119606	6	0.786
NZ_AP022573_2	2.1\|1046305\|28\|NZ_AP022573\|CRISPRCasFinder	1046305-1046332	28	NZ_CP049733	Rhizobium leguminosarum strain A1 plasmid pRL10, complete sequence	457843-457870	6	0.786
NZ_AP022573_2	2.1\|1046305\|28\|NZ_AP022573\|CRISPRCasFinder	1046305-1046332	28	NZ_CP053443	Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eC, complete sequence	102104-102131	6	0.786
NZ_AP022573_2	2.1\|1046305\|28\|NZ_AP022573\|CRISPRCasFinder	1046305-1046332	28	NZ_CP018232	Rhizobium leguminosarum strain Vaf-108 plasmid unnamed4, complete sequence	170773-170800	6	0.786
NZ_AP022573_2	2.1\|1046305\|28\|NZ_AP022573\|CRISPRCasFinder	1046305-1046332	28	NZ_CP016291	Rhizobium leguminosarum strain Vaf10 plasmid unnamed6, complete sequence	264358-264385	6	0.786
NZ_AP022573_2	2.1\|1046305\|28\|NZ_AP022573\|CRISPRCasFinder	1046305-1046332	28	NC_022049	Paracoccus aminophilus JCM 7686 plasmid pAMI4, complete sequence	54016-54043	6	0.786
NZ_AP022573_2	2.1\|1046305\|28\|NZ_AP022573\|CRISPRCasFinder	1046305-1046332	28	NZ_CP022568	Rhizobium leguminosarum bv. viciae strain BIHB 1148 plasmid pSK04, complete sequence	204023-204050	6	0.786
NZ_AP022573_2	2.1\|1046305\|28\|NZ_AP022573\|CRISPRCasFinder	1046305-1046332	28	NZ_CP053207	Rhizobium leguminosarum bv. trifolii TA1 plasmid pRltTA1C, complete sequence	486906-486933	6	0.786
NZ_AP022573_2	2.1\|1046305\|28\|NZ_AP022573\|CRISPRCasFinder	1046305-1046332	28	MT491208	Pseudomonas phage vB_PaeM_USP_25, complete genome	3796-3823	6	0.786
NZ_AP022573_5	5.1\|5540845\|34\|NZ_AP022573\|CRISPRCasFinder	5540845-5540878	34	NZ_AP022607	Mycobacterium branderi strain JCM 12687 plasmid pJCM12687	492091-492124	6	0.824
NZ_AP022573_5	5.1\|5540845\|34\|NZ_AP022573\|CRISPRCasFinder	5540845-5540878	34	NZ_AP022607	Mycobacterium branderi strain JCM 12687 plasmid pJCM12687	509632-509665	6	0.824
NZ_AP022573_5	5.1\|5540845\|34\|NZ_AP022573\|CRISPRCasFinder	5540845-5540878	34	NZ_CP006368	Aureimonas sp. AU20 plasmid pAU20a, complete sequence	400998-401031	6	0.824
NZ_AP022573_2	2.1\|1046305\|28\|NZ_AP022573\|CRISPRCasFinder	1046305-1046332	28	NZ_CP054842	Acidovorax sp. 16-35-5 plasmid unnamed2, complete sequence	28319-28346	7	0.75
NZ_AP022573_4	4.1\|4945325\|32\|NZ_AP022573\|CRISPRCasFinder	4945325-4945356	32	NZ_CP045332	Labrenzia sp. THAF191b plasmid pTHAF191b_d, complete sequence	21172-21203	7	0.781
NZ_AP022573_4	4.1\|4945325\|32\|NZ_AP022573\|CRISPRCasFinder	4945325-4945356	32	NZ_CP045348	Labrenzia sp. THAF187b plasmid pTHAF187b_d, complete sequence	11350-11381	7	0.781
NZ_AP022573_4	4.1\|4945325\|32\|NZ_AP022573\|CRISPRCasFinder	4945325-4945356	32	NZ_CP045337	Labrenzia sp. THAF191a plasmid pTHAF191a_d, complete sequence	236-267	7	0.781
NZ_AP022573_4	4.1\|4945325\|32\|NZ_AP022573\|CRISPRCasFinder	4945325-4945356	32	NZ_CP031754	Rhodobacter sphaeroides strain EBL0706 plasmid p.C, complete sequence	22292-22323	7	0.781
NZ_AP022573_3	3.1\|1782075\|37\|NZ_AP022573\|CRISPRCasFinder	1782075-1782111	37	NC_023067	Streptomyces sp. F2 plasmid pFP3, complete sequence	28287-28323	10	0.73
NZ_AP022573_3	3.1\|1782075\|37\|NZ_AP022573\|CRISPRCasFinder	1782075-1782111	37	NC_017833	Streptomyces sp. FR1 plasmid pFP4, complete sequence	35113-35149	10	0.73

1. spacer 6.1|5637476|26|NZ_AP022573|CRISPRCasFinder matches to NZ_CP029359 (Azospirillum sp. CFH 70021 plasmid unnamed4) position: , mismatch: 3, identity: 0.885

ccgccgggctcgcgatcaccgctggg	CRISPR spacer
ccgccgggcgcgcgaccaccgctggc	Protospacer
********* *****.*********

2. spacer 6.1|5637476|26|NZ_AP022573|CRISPRCasFinder matches to NZ_CP016083 (Streptomyces sp. SAT1 plasmid unnamed3, complete sequence) position: , mismatch: 4, identity: 0.846

ccgccgggctcgcgatcaccgctggg	CRISPR spacer
tcgccgggctcgcggtcaccgcgggc	Protospacer
.*************.******* **

3. spacer 6.1|5637476|26|NZ_AP022573|CRISPRCasFinder matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 4, identity: 0.846

ccgccgggctcgcgatcaccgctggg	CRISPR spacer
tcgccggggtcgcgatcgccgctggc	Protospacer
.******* ********.*******

4. spacer 6.1|5637476|26|NZ_AP022573|CRISPRCasFinder matches to NZ_CP015735 (Arthrobacter sp. U41 plasmid unnamed3, complete sequence) position: , mismatch: 4, identity: 0.846

ccgccgggctcgcgatcaccgctggg	CRISPR spacer
tcgccgggatcgcgaacaccgctgtg	Protospacer
.******* ****** ******** *

5. spacer 6.1|5637476|26|NZ_AP022573|CRISPRCasFinder matches to NZ_CP047899 (Pseudarthrobacter sp. YJ56 plasmid unnamed1, complete sequence) position: , mismatch: 4, identity: 0.846

ccgccgggctcgcgatcaccgctggg	CRISPR spacer
tcgccgggatcgcgaacaccgctgtg	Protospacer
.******* ****** ******** *

6. spacer 2.1|1046305|28|NZ_AP022573|CRISPRCasFinder matches to NC_012811 (Methylorubrum extorquens AM1 megaplasmid, complete sequence) position: , mismatch: 5, identity: 0.821

cgcctacctggccctcaaggcgcgccag	CRISPR spacer
cgcctacctagccctcaaggcgaagcac	Protospacer
*********.************ . **

7. spacer 2.1|1046305|28|NZ_AP022573|CRISPRCasFinder matches to NZ_CP025613 (Niveispirillum cyanobacteriorum strain TH16 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.821

cgcctacctggccctcaaggcgcgccag	CRISPR spacer
cccctatctggccgtcaaggcgcgcgac	Protospacer
* ****.****** *********** *

8. spacer 2.1|1046305|28|NZ_AP022573|CRISPRCasFinder matches to NZ_CP021084 (Deinococcus ficus strain CC-FR2-10 plasmid pDFI3, complete sequence) position: , mismatch: 5, identity: 0.821

cgcctacctggccctcaaggcgcgccag	CRISPR spacer
cgaggaccaggccctcaaggagcgccag	Protospacer
**   *** *********** *******

9. spacer 2.1|1046305|28|NZ_AP022573|CRISPRCasFinder matches to MT491207 (Pseudomonas phage vB_PaeM_USP_18, complete genome) position: , mismatch: 5, identity: 0.821

cgcctacctggccctcaaggcgcgccag	CRISPR spacer
ccgcaacctgatcctcaaggcgcgccag	Protospacer
*  * *****..****************

10. spacer 6.1|5637476|26|NZ_AP022573|CRISPRCasFinder matches to NZ_CP012265 (Cronobacter condimenti 1330 strain LMG 26250 plasmid pCCO1, complete sequence) position: , mismatch: 5, identity: 0.808

ccgccgggctcgcgatcaccgctggg	CRISPR spacer
ccgccgggcttgcgatcaccgcactt	Protospacer
**********.***********

11. spacer 6.1|5637476|26|NZ_AP022573|CRISPRCasFinder matches to NZ_CP022991 (Paraburkholderia aromaticivorans strain BN5 plasmid pBN1, complete sequence) position: , mismatch: 5, identity: 0.808

ccgccgggctcgcgatcaccgctggg	CRISPR spacer
ccgccgcgctcgcgatcaccgggcgc	Protospacer
****** **************   *

12. spacer 6.1|5637476|26|NZ_AP022573|CRISPRCasFinder matches to NZ_CP007130 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence) position: , mismatch: 5, identity: 0.808

ccgccgggctcgcgatcaccgctggg	CRISPR spacer
gcgccgggcgcgcgttcaccgctgcc	Protospacer
 ******** **** *********

13. spacer 6.1|5637476|26|NZ_AP022573|CRISPRCasFinder matches to MK279848 (Gordonia phage Dorito, complete genome) position: , mismatch: 5, identity: 0.808

ccgccgggctcgcgatcaccgctggg	CRISPR spacer
gcgccgagctcgcgatcatcgctgat	Protospacer
 *****.***********.*****.

14. spacer 2.1|1046305|28|NZ_AP022573|CRISPRCasFinder matches to NZ_CP040720 (Rhodococcus pyridinivorans strain YF3 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.786

cgcctacctggccctcaaggcgcgccag	CRISPR spacer
cgcctaccgggccctcaaggcccgaacc	Protospacer
******** ************ **

15. spacer 2.1|1046305|28|NZ_AP022573|CRISPRCasFinder matches to NZ_CP050083 (Rhizobium leguminosarum bv. trifolii strain 31B plasmid pRL31b3, complete sequence) position: , mismatch: 6, identity: 0.786

cgcctacctggccctcaaggcgcgccag	CRISPR spacer
cgccaacctggccctcaaggagccggtg	Protospacer
**** *************** **    *

16. spacer 2.1|1046305|28|NZ_AP022573|CRISPRCasFinder matches to NZ_CP050100 (Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b3, complete sequence) position: , mismatch: 6, identity: 0.786

cgcctacctggccctcaaggcgcgccag	CRISPR spacer
cgccaacctggccctcaaggagccggtg	Protospacer
**** *************** **    *

17. spacer 2.1|1046305|28|NZ_AP022573|CRISPRCasFinder matches to NC_008381 (Rhizobium leguminosarum bv. viciae 3841 plasmid pRL10, complete sequence) position: , mismatch: 6, identity: 0.786

cgcctacctggccctcaaggcgcgccag	CRISPR spacer
cgccaacctggccctcaaggagccggtg	Protospacer
**** *************** **    *

18. spacer 2.1|1046305|28|NZ_AP022573|CRISPRCasFinder matches to NZ_CP025017 (Rhizobium leguminosarum strain Norway plasmid pRLN5, complete sequence) position: , mismatch: 6, identity: 0.786

cgcctacctggccctcaaggcgcgccag	CRISPR spacer
cgccaacctggccctcaaggagccggtg	Protospacer
**** *************** **    *

19. spacer 2.1|1046305|28|NZ_AP022573|CRISPRCasFinder matches to NZ_CP049733 (Rhizobium leguminosarum strain A1 plasmid pRL10, complete sequence) position: , mismatch: 6, identity: 0.786

cgcctacctggccctcaaggcgcgccag	CRISPR spacer
cgccaacctggccctcaaggagccggtg	Protospacer
**** *************** **    *

20. spacer 2.1|1046305|28|NZ_AP022573|CRISPRCasFinder matches to NZ_CP053443 (Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eC, complete sequence) position: , mismatch: 6, identity: 0.786

cgcctacctggccctcaaggcgcgccag	CRISPR spacer
cgccaacctggccctcaaggagccggtg	Protospacer
**** *************** **    *

21. spacer 2.1|1046305|28|NZ_AP022573|CRISPRCasFinder matches to NZ_CP018232 (Rhizobium leguminosarum strain Vaf-108 plasmid unnamed4, complete sequence) position: , mismatch: 6, identity: 0.786

cgcctacctggccctcaaggcgcgccag	CRISPR spacer
cgccaacctggccctcaaggagccggtg	Protospacer
**** *************** **    *

22. spacer 2.1|1046305|28|NZ_AP022573|CRISPRCasFinder matches to NZ_CP016291 (Rhizobium leguminosarum strain Vaf10 plasmid unnamed6, complete sequence) position: , mismatch: 6, identity: 0.786

cgcctacctggccctcaaggcgcgccag	CRISPR spacer
cgccaacctggccctcaaggagccggtg	Protospacer
**** *************** **    *

23. spacer 2.1|1046305|28|NZ_AP022573|CRISPRCasFinder matches to NC_022049 (Paracoccus aminophilus JCM 7686 plasmid pAMI4, complete sequence) position: , mismatch: 6, identity: 0.786

cgcctacctggccctcaaggcgcgccag	CRISPR spacer
cgccgtcctggccctcaaggcgcaggcg	Protospacer
****  *****************.   *

24. spacer 2.1|1046305|28|NZ_AP022573|CRISPRCasFinder matches to NZ_CP022568 (Rhizobium leguminosarum bv. viciae strain BIHB 1148 plasmid pSK04, complete sequence) position: , mismatch: 6, identity: 0.786

cgcctacctggccctcaaggcgcgccag	CRISPR spacer
cgccaacctggccctcaaggagccggtg	Protospacer
**** *************** **    *

25. spacer 2.1|1046305|28|NZ_AP022573|CRISPRCasFinder matches to NZ_CP053207 (Rhizobium leguminosarum bv. trifolii TA1 plasmid pRltTA1C, complete sequence) position: , mismatch: 6, identity: 0.786

cgcctacctggccctcaaggcgcgccag	CRISPR spacer
cgccaacctggccctcaaggagccggtg	Protospacer
**** *************** **    *

26. spacer 2.1|1046305|28|NZ_AP022573|CRISPRCasFinder matches to MT491208 (Pseudomonas phage vB_PaeM_USP_25, complete genome) position: , mismatch: 6, identity: 0.786

cgcctacctggccctcaaggcgcgccag	CRISPR spacer
ccggaacctgatcctcaaggcgcgccag	Protospacer
*    *****..****************

27. spacer 5.1|5540845|34|NZ_AP022573|CRISPRCasFinder matches to NZ_AP022607 (Mycobacterium branderi strain JCM 12687 plasmid pJCM12687) position: , mismatch: 6, identity: 0.824

ttcgcccggctacgccgcccttgcgatcgccacg	CRISPR spacer
cgcgcccggctgcgccgcgcttgcgatcgcctct	Protospacer
. *********.****** ************ *

28. spacer 5.1|5540845|34|NZ_AP022573|CRISPRCasFinder matches to NZ_AP022607 (Mycobacterium branderi strain JCM 12687 plasmid pJCM12687) position: , mismatch: 6, identity: 0.824

ttcgcccggctacgccgcccttgcgatcgccacg	CRISPR spacer
cgcgcccggctgcgccgcgcttgcgatcgcctct	Protospacer
. *********.****** ************ *

29. spacer 5.1|5540845|34|NZ_AP022573|CRISPRCasFinder matches to NZ_CP006368 (Aureimonas sp. AU20 plasmid pAU20a, complete sequence) position: , mismatch: 6, identity: 0.824

-ttcgcccggctacgccgcccttgcgatcgccacg	CRISPR spacer
gatcggcc-gctacgccgcccatgcgctcgccatg	Protospacer
  *** ** ************ **** ******.*

30. spacer 2.1|1046305|28|NZ_AP022573|CRISPRCasFinder matches to NZ_CP054842 (Acidovorax sp. 16-35-5 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.75

cgcctacctggccctcaaggcgcgccag	CRISPR spacer
gcggtacctggccgtcaaggcgcgcagg	Protospacer
    ********* *********** .*

31. spacer 4.1|4945325|32|NZ_AP022573|CRISPRCasFinder matches to NZ_CP045332 (Labrenzia sp. THAF191b plasmid pTHAF191b_d, complete sequence) position: , mismatch: 7, identity: 0.781

ccggccgaagcggccaagcactcggaggcggc	CRISPR spacer
tcggccgaagcggccaagcacgccgatatggt	Protospacer
.******************** * ** ..**.

32. spacer 4.1|4945325|32|NZ_AP022573|CRISPRCasFinder matches to NZ_CP045348 (Labrenzia sp. THAF187b plasmid pTHAF187b_d, complete sequence) position: , mismatch: 7, identity: 0.781

ccggccgaagcggccaagcactcggaggcggc	CRISPR spacer
tcggccgaagcggccaagcacgccgatatggt	Protospacer
.******************** * ** ..**.

33. spacer 4.1|4945325|32|NZ_AP022573|CRISPRCasFinder matches to NZ_CP045337 (Labrenzia sp. THAF191a plasmid pTHAF191a_d, complete sequence) position: , mismatch: 7, identity: 0.781

ccggccgaagcggccaagcactcggaggcggc	CRISPR spacer
tcggccgaagcggccaagcacgccgatatggt	Protospacer
.******************** * ** ..**.

34. spacer 4.1|4945325|32|NZ_AP022573|CRISPRCasFinder matches to NZ_CP031754 (Rhodobacter sphaeroides strain EBL0706 plasmid p.C, complete sequence) position: , mismatch: 7, identity: 0.781

ccggccgaagcggccaagcactcggaggcggc	CRISPR spacer
tcgggcgaagcggccaagctctcgggactggc	Protospacer
.*** ************** *****.. .***

35. spacer 3.1|1782075|37|NZ_AP022573|CRISPRCasFinder matches to NC_023067 (Streptomyces sp. F2 plasmid pFP3, complete sequence) position: , mismatch: 10, identity: 0.73

cgccggcggcggcacgtcaggtcccggcggcggcgga-----	CRISPR spacer
tggaggcggcggcacgccagctcccggcg-----ggacatcc	Protospacer
.*  ************.*** ********     ***

36. spacer 3.1|1782075|37|NZ_AP022573|CRISPRCasFinder matches to NC_017833 (Streptomyces sp. FR1 plasmid pFP4, complete sequence) position: , mismatch: 10, identity: 0.73

cgccggcggcggcacgtcaggtcccggcggcggcgga-----	CRISPR spacer
tggaggcggcggcacgccagctcccggcg-----ggacatcc	Protospacer
.*  ************.*** ********     ***

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

4112441 : 4177237

Mycobacterium_phage(40.0%)

transposase,integrase,protease

attL 4144537:4144582|attR 4149721:4149766

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_085254617.1\|4112441_4113842_+\|protease	type VII secretion-associated serine protease mycosin	V5UPA7	Mycobacterium_phage	5.1e-69	40.6
WP_085254616.1\|4113838_4114819_+	type VII secretion protein EccE	NA	NA	NA	NA
WP_085254680.1\|4114815_4116024_-	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_085254615.1\|4116160_4116946_+	trans-aconitate 2-methyltransferase	NA	NA	NA	NA
WP_085254614.1\|4116959_4118360_-	sulfatase	NA	NA	NA	NA
WP_085254613.1\|4118359_4119007_-	5,6-dimethylbenzimidazole synthase	NA	NA	NA	NA
WP_085254612.1\|4119074_4119359_+	hypothetical protein	NA	NA	NA	NA
WP_085254611.1\|4119342_4119825_-	hypothetical protein	NA	NA	NA	NA
WP_085254610.1\|4119883_4120549_+	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_085254609.1\|4120575_4121232_+	L,D-transpeptidase	NA	NA	NA	NA
WP_085254608.1\|4121243_4121744_-	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_085254607.1\|4121730_4122366_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_085254606.1\|4122404_4123631_+	hypothetical protein	NA	NA	NA	NA
WP_163645143.1\|4123796_4125707_+	Hsp70 family protein	NA	NA	NA	NA
WP_163645144.1\|4125799_4127143_+	hypothetical protein	NA	NA	NA	NA
WP_085256142.1\|4127208_4127610_+	hypothetical protein	NA	NA	NA	NA
WP_085256141.1\|4127610_4128207_-	DUF3060 domain-containing protein	NA	NA	NA	NA
WP_085256140.1\|4128216_4129314_+	NADP-dependent oxidoreductase	NA	NA	NA	NA
WP_085256139.1\|4129428_4130025_-	hypothetical protein	NA	NA	NA	NA
WP_085256138.1\|4130265_4131102_+	glycoside hydrolase family 16 protein	NA	NA	NA	NA
WP_085256146.1\|4131105_4132611_-	glycosyltransferase family 39 protein	NA	NA	NA	NA
WP_085256137.1\|4132661_4132967_+	hypothetical protein	NA	NA	NA	NA
WP_163645145.1\|4132992_4133661_+	GAP family protein	NA	NA	NA	NA
WP_085256136.1\|4133689_4134373_+	GAP family protein	NA	NA	NA	NA
WP_085256135.1\|4134363_4135092_-	hypothetical protein	NA	NA	NA	NA
WP_085256134.1\|4135117_4136608_+	bifunctional phosphatase PAP2/diacylglycerol kinase family protein	NA	NA	NA	NA
WP_085256133.1\|4136617_4136959_-	DUF732 domain-containing protein	NA	NA	NA	NA
WP_085256132.1\|4137155_4139006_+	hypothetical protein	NA	NA	NA	NA
WP_085256144.1\|4139114_4139561_+	hypothetical protein	NA	NA	NA	NA
WP_085256131.1\|4139488_4140118_+	M15 family metallopeptidase	NA	NA	NA	NA
WP_142280635.1\|4140218_4140905_+	TetR family transcriptional regulator	NA	NA	NA	NA
WP_085256129.1\|4141002_4141551_+	hypothetical protein	NA	NA	NA	NA
WP_085256128.1\|4141547_4144478_+	MMPL family transporter	NA	NA	NA	NA
4144537:4144582	attL	NA	NA	NA	NA
WP_142280636.1\|4144864_4145635_+	hypothetical protein	NA	NA	NA	NA
WP_142280634.1\|4145779_4146022_+	hypothetical protein	NA	NA	NA	NA
WP_085256125.1\|4146741_4147071_+	hypothetical protein	NA	NA	NA	NA
WP_085256124.1\|4147072_4148461_+\|integrase	tyrosine-type recombinase/integrase	A0A0E3XBN7	Gordonia_phage	8.5e-16	27.2
WP_085256123.1\|4148457_4149612_-	nucleotide-binding protein	NA	NA	NA	NA
WP_169717527.1\|4150038_4150701_+	hypothetical protein	A0A2D1GPL9	Mycobacterium_phage	2.0e-23	44.9
4149721:4149766	attR	NA	NA	NA	NA
WP_085256122.1\|4150737_4151310_+	dCTP deaminase	I4AZP2	Saccharomonospora_phage	4.5e-80	75.8
WP_085256121.1\|4151416_4153336_+	hypothetical protein	NA	NA	NA	NA
WP_163645146.1\|4153532_4154999_+	hypothetical protein	NA	NA	NA	NA
WP_163645221.1\|4154995_4156120_+	hypothetical protein	NA	NA	NA	NA
WP_085258024.1\|4157840_4159166_+	UDP-glucose/GDP-mannose dehydrogenase family protein	A0A127AXI2	Bacillus_phage	7.5e-70	36.0
WP_042909771.1\|4162351_4162777_-	hypothetical protein	NA	NA	NA	NA
WP_163645147.1\|4163105_4163918_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_042792003.1\|4167539_4168553_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_042792002.1\|4168679_4169000_+	2Fe-2S iron-sulfur cluster binding domain-containing protein	NA	NA	NA	NA
WP_051472937.1\|4169071_4170412_+	cytochrome P450	NA	NA	NA	NA
WP_042792000.1\|4170408_4171611_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_134770488.1\|4171827_4172520_+	hypothetical protein	NA	NA	NA	NA
WP_042791998.1\|4172516_4173017_+	PaaI family thioesterase	NA	NA	NA	NA
WP_085240917.1\|4173819_4173933_+\|transposase	transposase family protein	NA	NA	NA	NA
WP_142278381.1\|4173989_4174439_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_142278382.1\|4174416_4174863_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_082278410.1\|4176037_4177237_-\|transposase	IS110 family transposase	NA	NA	NA	NA

DBSCAN-SWA_2

5536805 : 5543476

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_085255006.1\|5536805_5537738_+	SDR family oxidoreductase	W8CYX9	Bacillus_phage	4.9e-07	29.1
WP_085255005.1\|5537672_5538707_-	DNA polymerase IV	F1C5A5	Cronobacter_phage	2.6e-17	28.0
WP_085255004.1\|5538706_5539315_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_163645174.1\|5539405_5539978_+	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	2.8e-05	30.3
WP_085255002.1\|5540535_5540775_+	glutaredoxin-like protein NrdH	V5UN81	Mycobacterium_phage	2.0e-21	65.3
WP_085255001.1\|5540882_5541341_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A217ER62	Bacillus_phage	3.3e-09	31.1
WP_085255000.1\|5541310_5543476_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	V9VI16	Lactococcus_phage	8.2e-207	51.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_AP022573

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection