CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_AP022616	Mycolicibacterium phocaicum strain JCM 15301	7 crisprs	csa3,cas3,PD-DExK,WYL,cas4,DEDDh,DinG,RT	1	5	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_AP022616_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022616_1

293207-293319

Orphan

Consensus_repeat	Method
GAAGTGTGAGTGGCGCAGGCCGTGGTTGCAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022616_1

>merge|NZ_AP022616|1|293207-293319|CRISPRCasFinder
GAAGTGTGAGTGGCGCAGGCCGTGGTTGCAGGGTGAACGCGGTCGAGCGGGCCCTTGTCGTTGAGCCTGAATCCTGGGCGCAGAAGTGTGAGTGGCGCAGGCCGTGGTTGCAG

>NZ_AP022616|1|1|293207-293319|CRISPRCasFinder
GAAGTGTGAGTGGCGCAGGCCGTGGTTGCAG	GGTGAACGCGGTCGAGCGGGCCCTTGTCGTTGAGCCTGAATCCTGGGCGCA
GAAGTGTGAGTGGCGCAGGCCGTGGTTGCAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022616.1\|WP_138249721.1\|291213_293097_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|237284
NZ_AP022616.1\|WP_138249724.1\|287579_288206_+\|TIGR02234-family-membrane-protein	unknown	unknown	gnl\|CDD\|378200
NZ_AP022616.1\|WP_061007347.1\|295484_295883_+\|DUF2752-domain-containing-protein	unknown	unknown	gnl\|CDD\|378499
NZ_AP022616.1\|WP_061006292.1\|302977_304426_-\|cytochrome-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|376587
NZ_AP022616.1\|WP_020103249.1\|297427_298288_+\|acyl-CoA-thioesterase-II	unknown	unknown	gnl\|CDD\|224857
NZ_AP022616.1\|WP_138249723.1\|289157_290429_+\|tryptophan-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|235288
NZ_AP022616.1\|WP_167526448.1\|300266_301874_-\|thiol-reductant-ABC-exporter-subunit-CydD	unknown	unknown	gnl\|CDD\|227321
NZ_AP022616.1\|WP_060999609.1\|288300_289119_+\|indole-3-glycerol-phosphate-synthase-TrpC	unknown	unknown	gnl\|CDD\|234710
NZ_AP022616.1\|WP_061007349.1\|293510_294122_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_AP022616.1\|WP_138249727.1\|282305_283103_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224044
NZ_AP022616.1\|WP_064859553.1\|285589_286045_-\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239315
NZ_AP022616.1\|WP_138249717.1\|301909_302965_-\|cytochrome-d-ubiquinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|376764
NZ_AP022616.1\|WP_138249725.1\|286077_287583_+\|anthranilate-synthase-component-I	unknown	unknown	gnl\|CDD\|184152
NZ_AP022616.1\|WP_138249719.1\|298753_300310_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|274331
NZ_AP022616.1\|WP_138249720.1\|294219_295374_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366009
NZ_AP022616.1\|WP_138249726.1\|283099_283771_-\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_AP022616.1\|WP_138249763.1\|283965_285603_+\|2-isopropylmalate-synthase	unknown	unknown	gnl\|CDD\|235154
NZ_AP022616.1\|WP_061007346.1\|295994_297413_+\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|180487
NZ_AP022616.1\|WP_138249722.1\|290425_291217_+\|tryptophan-synthase-subunit-alpha	unknown	unknown	gnl\|CDD\|237285
NZ_AP022616.1\|WP_133427728.1\|298304_298757_-\|DUF4190-domain-containing-protein	unknown	unknown	gnl\|CDD\|379388

Protein	Function_ID	Function_description	E-value
NZ_AP022616.1\|WP_138249721.1\|291213_293097_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|237284	PRK13108, PRK13108, prolipoprotein diacylglyceryl transferase; Reviewed.	5.3229e-168
NZ_AP022616.1\|WP_138249724.1\|287579_288206_+\|TIGR02234-family-membrane-protein	gnl\|CDD\|378200	pfam09534, Trp_oprn_chp, Tryptophan-associated transmembrane protein (Trp_oprn_chp). Members of this family are predicted transmembrane proteins with four membrane-spanning helices. Members are found in the Actinobacteria (Mycobacterium, Corynebacterium, Streptomyces), always associated with genes for tryptophan biosynthesis.	1.58303e-35
NZ_AP022616.1\|WP_061007347.1\|295484_295883_+\|DUF2752-domain-containing-protein	gnl\|CDD\|378499	pfam10825, DUF2752, Protein of unknown function (DUF2752). This family is conserved in bacteria. Many members are annotated as being putative membrane proteins.	1.66083e-14
NZ_AP022616.1\|WP_061006292.1\|302977_304426_-\|cytochrome-ubiquinol-oxidase-subunit-I	gnl\|CDD\|376587	pfam01654, Cyt_bd_oxida_I, Cytochrome bd terminal oxidase subunit I. This family are the alternative oxidases found in many bacteria which oxidize ubiquinol and reduce oxygen as part of the electron transport chain. This family is the subunit I of the oxidase E. coli has two copies of the oxidase, bo and bd', both of which are represented here In some nitrogen fixing bacteria, e.g. Klebsiella pneumoniae this oxidase is responsible for removing oxygen in microaerobic conditions, making the oxidase required for nitrogen fixation. This subunit binds a single b-haem, through ligands at His186 and Met393 (using SW:P11026 numbering). In addition His19 is a ligand for the haem b found in subunit II.	0
NZ_AP022616.1\|WP_020103249.1\|297427_298288_+\|acyl-CoA-thioesterase-II	gnl\|CDD\|224857	COG1946, TesB, Acyl-CoA thioesterase [Lipid metabolism].	1.30466e-102
NZ_AP022616.1\|WP_138249723.1\|289157_290429_+\|tryptophan-synthase-subunit-beta	gnl\|CDD\|235288	PRK04346, PRK04346, tryptophan synthase subunit beta; Validated.	0
NZ_AP022616.1\|WP_167526448.1\|300266_301874_-\|thiol-reductant-ABC-exporter-subunit-CydD	gnl\|CDD\|227321	COG4988, CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones].	1.05477e-149
NZ_AP022616.1\|WP_060999609.1\|288300_289119_+\|indole-3-glycerol-phosphate-synthase-TrpC	gnl\|CDD\|234710	PRK00278, trpC, indole-3-glycerol phosphate synthase TrpC.	7.37966e-132
NZ_AP022616.1\|WP_061007349.1\|293510_294122_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	8.3226e-12
NZ_AP022616.1\|WP_138249727.1\|282305_283103_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	2.65649e-73
NZ_AP022616.1\|WP_064859553.1\|285589_286045_-\|peroxiredoxin	gnl\|CDD\|239315	cd03017, PRX_BCP, Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing and detoxifying hydroperoxides. The protein was named BCP based on its electrophoretic mobility before its function was known. BCP shows substrate selectivity toward fatty acid hydroperoxides rather than hydrogen peroxide or alkyl hydroperoxides. BCP contains the peroxidatic cysteine but appears not to possess a resolving cysteine (some sequences, not all, contain a second cysteine but its role is still unknown). Unlike other PRXs, BCP exists as a monomer. The plant homolog of BCP is PRX Q, which is expressed only in leaves and is cellularly localized in the chloroplasts and the guard cells of stomata. Also included in this subfamily is the fungal nuclear protein, Dot5p (for disrupter of telomere silencing protein 5), which functions as an alkyl-hydroperoxide reductase during post-diauxic growth.	2.43745e-59
NZ_AP022616.1\|WP_138249717.1\|301909_302965_-\|cytochrome-d-ubiquinol-oxidase-subunit-II	gnl\|CDD\|376764	pfam02322, Cyt_bd_oxida_II, Cytochrome bd terminal oxidase subunit II. This family consists of cytochrome bd type terminal oxidases that catalyze quinol-dependent, Na+-independent oxygen uptake. Members of this family are integral membrane proteins and contain a protohaem IX centre B558. One member of the family, Klebsiella pneumoniae CydB, is implicated in having an important role in micro-aerobic nitrogen fixation in the enteric bacterium Klebsiella pneumoniae. The family forms an integral functional unit with subunit I, family Bac_Ubq_Cox, pfam01654.	1.68086e-102
NZ_AP022616.1\|WP_138249725.1\|286077_287583_+\|anthranilate-synthase-component-I	gnl\|CDD\|184152	PRK13571, PRK13571, anthranilate synthase component I; Provisional.	0
NZ_AP022616.1\|WP_138249719.1\|298753_300310_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|274331	TIGR02868, ABC_transporter_ATP-binding_protein, thiol reductant ABC exporter, CydC subunit. The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex.	3.31491e-125
NZ_AP022616.1\|WP_138249720.1\|294219_295374_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|366009	pfam00296, Bac_luciferase, Luciferase-like monooxygenase.	1.1041e-48
NZ_AP022616.1\|WP_138249726.1\|283099_283771_-\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	1.14312e-47
NZ_AP022616.1\|WP_138249763.1\|283965_285603_+\|2-isopropylmalate-synthase	gnl\|CDD\|235154	PRK03739, PRK03739, 2-isopropylmalate synthase; Validated.	0
NZ_AP022616.1\|WP_061007346.1\|295994_297413_+\|pyruvate-kinase	gnl\|CDD\|180487	PRK06247, PRK06247, pyruvate kinase; Provisional.	0
NZ_AP022616.1\|WP_138249722.1\|290425_291217_+\|tryptophan-synthase-subunit-alpha	gnl\|CDD\|237285	PRK13111, trpA, tryptophan synthase subunit alpha; Provisional.	4.1155e-117
NZ_AP022616.1\|WP_133427728.1\|298304_298757_-\|DUF4190-domain-containing-protein	gnl\|CDD\|379388	pfam13828, DUF4190, Domain of unknown function (DUF4190). This integral membrane domain is functionally uncharacterized. One of the membrane helices contains two GXXG motifs that are usually associated with dimerization.	7.19461e-08

>NZ_AP022616.1|WP_138249721.1|291213_293097_+|prolipoprotein-diacylglyceryl-transferase
MTTSLLAYIPSPAQGVWHLGPVPIRAYALCIITGIIAALIIGDRRWVARGGEPGVIYDIALWTVPFGLIGGRLYHLMTDWRTYFAEGGAGIAGAVRIWDGGLGIWGAVALGAVGAWIGCRRHGIPLPAFGDAVAPGVILAQAIGRLGNYFNQELYGRPTDLPWGLQIFQRSDGSGVVNPHLLNGVSTGQVYEVVHPTFLYELLWNLLVFFLLLWADRRFRLGHGRLFALYVAAYCVGRFGVELMRSDTATLIAGIRVNSFTSTFVFIGAVVYMMVAPRGREDPATLGGRQVDDAGDVLDFDTGVAVKVPAVVAAGAAATAASGGDADVADEADAVETQSDEPVALAEQAADAETAADESGGESVDSDEVEEADESDAEAADLDADEAEAVEVAEESEGTTESDEAAEEAAAETDVADGDDSADVEDAAEAEESAEAEESAEAVDSAEAAEEAAVETDVADADDSADVEDAAEDEESAEAVDSAEAADEAEEAEGTTESDADEAAVETEVADADDSADVEDAVEDEESEAAEEPEAEEAAEVEAVDESEEATDSESAEAESEDAEAEEAEAENAEAEDADAEAAEDDADAEPAEAPAPKGDATERVEPVGVPVWEPPAPRRRWWRRQG
>NZ_AP022616.1|WP_138249722.1|290425_291217_+|tryptophan-synthase-subunit-alpha
MSRLAGLFESCRAEGRSALIGYLPTGYPDVQTSIDAMVAMTESGCDIIEVGVAYSDPGMDGPVIAAATNTALQGGVRVRDALRAVEAISNAGGHAVVMTYWNPVLRWGVDAFARDLAAAGGLGLITPDLIPDEADEWFTVSDAHNLDRIFLVAPSSTPERLATTVQASRGFVYAASTMGVTGARDAVSNMAPELVSRVRAVSDIPVGVGLGVRSREQAAEIASYADGVIVGSALVSALGDGGIPAVRALSEELAHGVRQKVSA
>NZ_AP022616.1|WP_138249723.1|289157_290429_+|tryptophan-synthase-subunit-beta
MSDRTGTELPRMSAAVAEATSHDPDAKGHFGAYGGRLVPEALMAVIEEVTAAYDKVRTDQTFLDELDRLQQHYTGRPSPLYEATRLSEHAGGARLFLKREDLNHTGSHKINNVLGQALLAKRMGKTRVIAETGAGQHGVATATACALLGLECVVYMGAVDTARQALNVARMRLLGGTVVSVEAGSATLKDAINEAFRDWVTNADDTYYCFGTAAGPHPFPVMVRDFQRVIGLEARVQIQQQAGRLPDAVTACVGGGSNAIGVFHAFIDDPGVRLVGFEAAGDGVETGRHAATFTGGSPGAFQGSFSYLLQDEDGQTIESHSISAGLDYPGVGPEHAYLKDVGRAEYRPVTDTEAMEAFGLLCRTEGIIPAIESAHAVAGALKLGSELGPGSVIVVNLSGRGDKDVETAAKWFGLLDGETGEAS
>NZ_AP022616.1|WP_060999609.1|288300_289119_+|indole-3-glycerol-phosphate-synthase-TrpC
MTSGTVLDSIIEGVRADVAAREAALSLTEVKERAKKAPTAKDALAALREPGIGVIAEVKRASPSKGALAQIDDPAKLAKAYESGGARVISVLTEERRFNGSLADLDAVRAAVSIPVLRKDFIVTPYQIHEARAHGADMLLLIVAALEQSVLTSMIDRTESLGMTPLVEVHTEEEADRAIQAGAKVIGVNARDLKTLEVDRDCFGRIAPGLPSNIIRIAESGVRGTADLLAYAGAGADAVLVGEGLVTSGDPRSAVADLVTAGTHPSCPKPAR
>NZ_AP022616.1|WP_138249724.1|287579_288206_+|TIGR02234-family-membrane-protein
MRTTRTAQVLLLVAALMLWGASRLPWVDVSSFDGLGQPKTTTLSGAAWSTALIPLALLAGAAAVAALAVRGWALRLLALLVAVASAGMGYLAISLWAVTDVSVRAADMAQIAVMFLVGTQRHYWGAGVTLGAAVLTLVGAVLLMRSARRGAAGPATTKYAAPGARREAAQDETADGMSERMIWDAIDEGRDPTQVEGRDPTQNDGGTK
>NZ_AP022616.1|WP_138249725.1|286077_287583_+|anthranilate-synthase-component-I
MKTTSREEFQALAAEHRVVPVTRKVLADSETPLSAYRKLAANRPGTFLLESAENGRSWSRWSFIGAGAPSALTVKDGEAVWLGSTPQDAPSGGDPLQAVRDTLALLQTAPVPGLPPLSSGLVGYFAYDMVRRLERLPELAKDDLKLPDMVLLLATDMAAVDHHEGTITLIANAVNWNGTDERVDWAYDDAVARLDVMTRALGEPLSSSIATFDRPQPQPRQQRTVEEYTAIVEKLVGDIEAGEAFQVVPSQRFELDTPADPLDVYRVLRVTNPSPYMYLLNVPNAEGGLDFSVVGSSPEALVTVKDGVATTHPIAGTRWRGATEEDDILLEKELLADDKERSEHLMLVDLGRNDLGRVCKPGTVRVEDYSHIERYSHVMHLVSTVTGHLADDKTALDAVTACFPAGTLSGAPKVRAMELIEEVELTRRGLYGGVLGYLDFAGNADFAIAIRTALMRGGTAYVQAGGGVVADSNGPYEYNESSNKAKAVLAAIAAAETLSEP
>NZ_AP022616.1|WP_064859553.1|285589_286045_-|peroxiredoxin
MKRGDLVAEFNLPDQTGTNRSLSELLADGPIVLFFYPAAMTPGCTMEACHFRDLAAEFAAVGASRVGISMDAVEKQDKFAEKHSFDYPLLSDTSGAVAEAFGVKRGLLGKLMPVKRTTFVIDTDRRVLEVIASEISMDSHADKALEVLRAR
>NZ_AP022616.1|WP_138249763.1|283965_285603_+|2-isopropylmalate-synthase
MPWHRYADVFDRVEIPPVKRDWPSNRITAAPLWVPVDLRDGNQALAEPMDPDRKRRFFEQLVAMGYKEIEVGYPSASQTDFDFVRLLAETDIAPPDVTIAVFTPARRDLIERTVDSVRGMRNDVVIHMYTATAPTWRNTVLGKDRDELRSLILHGALDVLTLTEGMPNIRFQFSPEVFNLTEPDYVLEICDAVTQLWDATESRPVILNLPATVEVATPNVYADQIEYMHRNLARRDAVILSVHPHNDRGTGVACAELAVLAGAQRVEGCVFGNGERTGNVDIATLALNLYAQGVDPMIDFSDIDAIARTVAHCTRMPIHERHPYVGDLVHTAFSGTHQDAIKKGLAEHRARAAAENRDEREIDWRVPYLPIDPADIGRSYDAVIRVNSQSGKGGIAYLLHTGYGLDLPRRLQIDFARHVQAHTDGSGTEVTAAELYDLFEATYLGCGGPVELKDWHVSSDDTTEITVTVNGIARTSTHRGVGPVEALTQALADVDRPVEILGLTQQSIGATAVTYLEHRGGWSCGRSDSVLTASLAAVIRAANAP
>NZ_AP022616.1|WP_138249726.1|283099_283771_-|FadR-family-transcriptional-regulator
MVSQVSRQPLAAQAAQLLLTRIKDGEWALGQRLPGETTLAAQLGVGRSTLREAIRELAGKGVLDSRQGAGVFVIALDVTDDWDTVLRSANIASVIEARIAIEAEGAALAATRRTPADLRTIRRTLAARGVTGQSVPEHVDADMAFHRAVIAAAHNDVLTQLFDAFLPRLRLAMIDMLKIRPIASEPCDHALHQQLADAIVARDPAAAAAASRTHLSALKESFT
>NZ_AP022616.1|WP_138249727.1|282305_283103_-|ATP-binding-cassette-domain-containing-protein
MTPVLEIDNVTFRREGKQIIDGISLTVQEGEHWALLGPNGAGKSTLLGFCGAVTFPTTGVVRVLGAQMGRTDLAPLRRSIGHVNPRHRLQYPLTVREVVLTGITGTIDTAARWTPTADDIARADELIGTVGLPHRADAVWPTLSQGERGRTLIARALIAEPRLLLLDEPTTGLDVAAREQLLETLDTLEHSHPEMASILVTHHLEELPTSTSHALLISGGRTVAVGPAVETVTTDHVSEAFSHPVEVGYDHGRWSARAKAGRVIA
>NZ_AP022616.1|WP_061007349.1|293510_294122_+|TetR/AcrR-family-transcriptional-regulator
MDDIADGVQLQQSRQDRILNAALNVFAQRGTSDATLQMVADTAGVSVGLVQHHFGTKDGLIKAVDDVAMKLISSTMFAALESPGPDSVAAIGRAVHGLLTDHLVVMDYLGRAVASETPSGIAIFDAMARIGIDRWQRMIDTGDAAEGLDAVWAGLNPLVLTLGSVILRRHLDRHLPASFTSDPELARWEESVNELIRHGQLRQ
>NZ_AP022616.1|WP_138249720.1|294219_295374_-|LLM-class-flavin-dependent-oxidoreductase
MARNTGFRVGTSDVLLAARPTVDALTRADYLGAVATGVDSFWVPDHLNQLFPRSLWQPKYCGATKVIPTIDASLEPWTMLGHIAARNRVGRLRLGVAVTDTGRRNPAVTAQAAATLHLLTRGRAILGIGPGEREGNEPYGVDWSKPVARFEEAMATIRALWDSGGELVNRDSPFFPLRNAVFELPPYRGKWPEIWIAAHGPRMLRAAGRYGDAYFPAFPHQPKDYAQRLEVVRTAASDAGRDPKAVLPAVMLFVVTGRSRDDVDAALDTEVLKSFALNASDEMFGRHGAEHPLGPGFSGAQDFLPHSIDEETALSLIDAVPPSLMRDICLNGTPDEIVEQVAEWRDCGVRYVVLANLSFLRRNLRKGLASVQPFNQIVRRLKRL
>NZ_AP022616.1|WP_061007347.1|295484_295883_+|DUF2752-domain-containing-protein
MTSAARVARVAGVAGTGAVAVATLTYIGVADPHRPGFGFPPCPFKALTGWNCPLCGGLRMTHDVLHGDLSAAVVDNVFALVGLPLLTVWLVVCWRRRLSVAPPLVTALVAMVLWTVVRNLPGFPLVPTFTQS
>NZ_AP022616.1|WP_061007346.1|295994_297413_+|pyruvate-kinase
MNRRGKIVCTLGPATSTDATVLALVEAGMDVARLNFSHGAHADHETAYKRVRAASDAAGRAVGILADLQGPKIRLGRFADGPTEWRTGETVRITVDDCDGSHDRVSTTYKQLAEDARAGDRLLVDDGKVGLVVDKIDGNDVVCTVTEGGPVSNNKGLSLPGMNVSVPALSEKDIDDLKFALKLGVDLIALSFVRSPADIELVHEVMDEVGRRVPVIAKLEKPEAVDNLEAIVLAFDAIMVARGDLGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLESMIENSRPTRAEASDVANAILDGADAVMLSGETSVGKYALEAVRTMARIVKAVEANSTDAPPLTHVPRTKRGVISYAARDIGERLDAKALVAFTQSGDTVRRLSRLHTPLPLLAFTDLPEVRSQLALTWGTETFIVPQMDSTDGMIQEVDKALLELDRYKRGDLVVIVAGAPPGTVGSTNLIHVHRIGEEDH
>NZ_AP022616.1|WP_020103249.1|297427_298288_+|acyl-CoA-thioesterase-II
MTTADFEELLKVLDVTQVDDDTFTGGHPSRNPVRTFGGQMMAQAFVAASRTVPPKLPPTTLSTHFIAGGDPERDLEFKVVRLRDERRFANRRVDVMQGDTLLATALVSHLAGGRSLEHSVKAPVVPDPLSLPTIDDLLKGYEETVPLFVEALKPIEWRYTNDPAWVMRDKGGKLDHNRVWLKTMGAMPDDPVLHAAALVYSSDTTLLDSIITTHGLSWGHDRIFAVTMNHTVWFHRPIKFDEWVLYSTTSPVAADSRGLASGHFFDRAGQVLATVTQEGIVKHFPG
>NZ_AP022616.1|WP_133427728.1|298304_298757_-|DUF4190-domain-containing-protein
MSMYPGGGYPPPPPPPYADQGYGAYTSTPRNGMGTAALVLGIVGLLTSWSVIGGLLFGLGAVACGILGRGRVKQGLADNGVVAGAGIVLGALATVLAVVFVFVVIGFYRQVGFSDYTDCMTRAGQDQNAQSTCVQDFRGRIEKEFGVKVD
>NZ_AP022616.1|WP_138249719.1|298753_300310_-|ATP-binding-cassette-domain-containing-protein
MRSSGREVLPVSTVRFAIDLLRPRLPRLALAVFLGSAALGSALALAGVSAWLITRAWQQPPILELSVAVVAVRLFGISRGVLGYCERLASHDVALRAAGRARTELYRRLSAAPPATVLRLSSGELVSRAGASVDDLADTLVRSVLPVAVATVLSTATVIVIAVISPAAALALAAGLVVAGVWAPWQAARAAEATENLAAVHHSDRDAAVMLALDHAAELAVAGRLGGVIAQATADHRRWGDAADRAARPAALAGAVPILATGASAIAAIVAAISLTSTVAPTTLAILMLLPLSAFEATGALPGAAVQLTRARIAIARLTAMLAEHPDDRALMAVPPLQVAPGDRVAVLGASGRGKTTLLLSTADRFNETDSPAGFFAEDAHLFDTTLRDNLLVARGDATDGELTAALTRVGLAPWLGTLPDGLSTLLSGGAAAVSAGQRRRLLLARALLTDFPVVLLDEPTEHLDAADSHRLLAELLTPGAMFGADRAVVVATHQLPPDVPCTVLNLDSSNDGYPAQS
>NZ_AP022616.1|WP_167526448.1|300266_301874_-|thiol-reductant-ABC-exporter-subunit-CydD
MRRHLAATVGSGVVIAAATLAAAVLTAHVVAGFITTRAPLSHWIPQLLALAALWSLRAGAQWWQARLGQHGATATIADLDAQVLSAVTALPPHRRQAVHDEAAILLTRGIDGLRPYFTRYLPAVVMSVLLTPAAVIVIAWYDVKSALVVLIALPLIPLFMVLIGVMTTERSAAALAAMATLQSRLLDLIAGIPTLRALGRAEGAAPRITELSDAHRHSALATLRIAFLSALVLELLATLGVALVAVGVGLRLVSGGVTLPVALTVLLLAPEVFWPLRRVGVEFHAAQDGKVAFGQAYRLLEDAGQPEPGTARIGARPTIDLEHISIDGRDGPAPHNLTLRATPGSVTVLTGPNGSGKSTALQAILGLTTPDAGRVRVGDDEQRCDVDALDRQHWWHQIGWLPQRPVLVPGTVRENLELLGALPDLDSACRASGFDEVLATLPAGLDTVLGRGGSGLSLGQRQRLALARVLGRPSPVLLLDEPTSHLNAELEIRVLQAIRARAAAGATVIVVGHRDAVLAIGDEIVRAGGASRVHS
>NZ_AP022616.1|WP_138249717.1|301909_302965_-|cytochrome-d-ubiquinol-oxidase-subunit-II
MTLQHLWFVILAALFLGFFVLEGFDFGVGMLMGFFGRAADGDEGDAEQYRRAALNTIGPVWDGNEVWIITAGAAMFAAFPGMYATVFSGLYLPLLAILVGMIVRVCAIEWRGKIDDPQWRRWADIGIAMGSWLPAVLWGVAFASILRGLPVDARHQIQLSFGDVLNPYSLLGGIATAGLFAFHGAVFVTLKTEGAVHDTARRFATRLTVPVTVIVAVFGIWTQVAYGNDVTWTALGVAVVAQFSAVRLVWTRRADGWAFAATAIVVAAVVTLLFSCLYPNLVPSTLDPAWSLTIHNASSTPYTLKVMTWAALLLTPLVICYQGWTYWVFRQRISAAHIPASIGLSRNGGSH
>NZ_AP022616.1|WP_061006292.1|302977_304426_-|cytochrome-ubiquinol-oxidase-subunit-I
MDALDVSRWQFGITTVYHFILVPLTIGLAPLLAVMQTVWVVTGNPAWYRLTKFFGKLFLINFALGVATGIVQEFQFGMNWSEYSRFVGDVFGAPLALEGLAAFFFESTFIGLWIFGWTKLPRLVHLACIWIVAFGVNASAFFIISANSFMQHPVGAHYNPETGRAELTSIWELLTNNTGIAAFTHTVGGAILTASTFVAAISAWWMVRSGNTEESRTMFRPAALLGCSVALVAAASLTLTGDAQGKLMFVQQPMKMASAESLCHTETDPDFSVLTIGTHNNCDSVMHVIEVPYVLPFLAESKFEGVRLEGVQDLQKAYEAKYGPGDYRPNLFVTYWSFRMMIGLLAFPGLFALTTLWLTRKGRIPTQRWLSIFALVTLPMPFLANSAGWVFTEMGRQPWVVATNPTGDPNLHLTIRQGVSAHSAGTVWISLITFTALYALLAVIWFWLIRRYTLEGPLEHDAEPAPPTPPGSDDVAPLSFAY

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Crispr_ID: NZ_AP022616_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022616_2

2548787-2548900

Orphan

Consensus_repeat	Method
TCGCGTTGACCCTGAACCCAGGGCGCGAAAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022616_2

>merge|NZ_AP022616|2|2548787-2548900|CRISPRCasFinder
TCGCGTTGACCCTGAACCCAGGGCGCGAAAAGCTGAGTAAGCCGCGCCCACACCGCAGGGTCAACACCGGGGCACCGTCGACTCGCGTTGACCCTGAACCCAGGGCGCAAAAAG

>NZ_AP022616|2|2|2548787-2548900|CRISPRCasFinder
TCGCGTTGACCCTGAACCCAGGGCGCGAAAAG	CTGAGTAAGCCGCGCCCACACCGCAGGGTCAACACCGGGGCACCGTCGAC
TCGCGTTGACCCTGAACCCAGGGCGCAAAAAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022616.1\|WP_138249620.1\|2546917_2547751_-\|RNA-polymerase-sigma-factor-SigE	unknown	unknown	gnl\|CDD\|236606
NZ_AP022616.1\|WP_138249621.1\|2549045_2549699_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|375436
NZ_AP022616.1\|WP_138249617.1\|2540739_2542431_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223944
NZ_AP022616.1\|WP_167526462.1\|2543761_2544400_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_AP022616.1\|WP_138249623.1\|2550615_2552253_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226089
NZ_AP022616.1\|WP_073697662.1\|2556131_2556332_-\|DUF3117-domain-containing-protein	unknown	unknown	gnl\|CDD\|371461
NZ_AP022616.1\|WP_167526387.1\|2538374_2538599_-\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|238126
NZ_AP022616.1\|WP_064857794.1\|2540118_2540670_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_AP022616.1\|WP_138249625.1\|2553008_2553593_+\|DUF4126-domain-containing-protein	unknown	unknown	gnl\|CDD\|379253
NZ_AP022616.1\|WP_138249651.1\|2548135_2548747_+\|O-methyltransferase	unknown	unknown	gnl\|CDD\|226607
NZ_AP022616.1\|WP_138249626.1\|2554960_2556130_+\|glycogen-synthase	unknown	unknown	gnl\|CDD\|273997
NZ_AP022616.1\|WP_061010717.1\|2553668_2554883_-\|glucose-1-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|234846
NZ_AP022616.1\|WP_138249622.1\|2549695_2550619_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_AP022616.1\|WP_138249627.1\|2556452_2557034_-\|DNA-3-methyladenine-glycosylase-I	unknown	unknown	gnl\|CDD\|377025
NZ_AP022616.1\|WP_138249618.1\|2542472_2543558_-\|DUF2236-domain-containing-protein	unknown	unknown	gnl\|CDD\|378343
NZ_AP022616.1\|WP_138249624.1\|2552261_2552936_+\|isoprenylcysteine-carboxylmethyltransferase-family-protein	unknown	unknown	gnl\|CDD\|224931
NZ_AP022616.1\|WP_138249619.1\|2544413_2544842_-\|Sec-independent-protein-translocase-subunit-TatB	unknown	unknown	gnl\|CDD\|179538
NZ_AP022616.1\|WP_061007153.1\|2546419_2546827_-\|RNA-polymerase-subunit-sigma-70	unknown	unknown	gnl\|CDD\|274904
NZ_AP022616.1\|WP_060999033.1\|2557030_2557336_-\|DivIVA-domain-containing-protein	unknown	unknown	gnl\|CDD\|274639
NZ_AP022616.1\|WP_135355546.1\|2544841_2546335_-\|trypsin-like-serine-protease	unknown	unknown	gnl\|CDD\|273938

Protein	Function_ID	Function_description	E-value
NZ_AP022616.1\|WP_138249620.1\|2546917_2547751_-\|RNA-polymerase-sigma-factor-SigE	gnl\|CDD\|236606	PRK09647, PRK09647, RNA polymerase sigma factor SigE; Reviewed.	1.01541e-131
NZ_AP022616.1\|WP_138249621.1\|2549045_2549699_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|375436	pfam17933, TetR_C_25, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in Rv1219c of Mycobacterium tuberculosis. Structural studies indicate that the helix alpha 10 of the C-terminal end of Rv1219c forms a long arm feature, a feature which is unique in Rv1219c compared to some other members of the TetR family. Furthermore, it has been shown that substrate binding occurs in the C-terminal regulatory domain of Rv1219c.	1.76617e-54
NZ_AP022616.1\|WP_138249617.1\|2540739_2542431_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|223944	COG1012, PutA, NAD-dependent aldehyde dehydrogenases [Energy production and conversion].	3.69186e-14
NZ_AP022616.1\|WP_167526462.1\|2543761_2544400_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	6.64247e-06
NZ_AP022616.1\|WP_138249623.1\|2550615_2552253_+\|ABC-transporter-permease	gnl\|CDD\|226089	COG3559, TnrB3, Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane].	2.88506e-155
NZ_AP022616.1\|WP_073697662.1\|2556131_2556332_-\|DUF3117-domain-containing-protein	gnl\|CDD\|371461	pfam11314, DUF3117, Protein of unknown function (DUF3117). This family of proteins with unknown function appears to be restricted to Actinobacteria.	1.73879e-23
NZ_AP022616.1\|WP_167526387.1\|2538374_2538599_-\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	gnl\|CDD\|238126	cd00207, fer2, 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.	2.49858e-15
NZ_AP022616.1\|WP_064857794.1\|2540118_2540670_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	5.58905e-16
NZ_AP022616.1\|WP_138249625.1\|2553008_2553593_+\|DUF4126-domain-containing-protein	gnl\|CDD\|379253	pfam13548, DUF4126, Domain of unknown function (DUF4126).	1.20245e-40
NZ_AP022616.1\|WP_138249651.1\|2548135_2548747_+\|O-methyltransferase	gnl\|CDD\|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	3.47264e-61
NZ_AP022616.1\|WP_138249626.1\|2554960_2556130_+\|glycogen-synthase	gnl\|CDD\|273997	TIGR02149, glgA_Coryne, glycogen synthase, Corynebacterium family. This model describes Corynebacterium glutamicum GlgA and closely related proteins in several other species. This enzyme is required for glycogen biosynthesis and appears to replace the distantly related TIGR02095 family of ADP-glucose type glycogen synthase in Corynebacterium glutamicum, Mycobacterium tuberculosis, Bifidobacterium longum, and Streptomyces coelicolor. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NZ_AP022616.1\|WP_061010717.1\|2553668_2554883_-\|glucose-1-phosphate-adenylyltransferase	gnl\|CDD\|234846	PRK00844, glgC, glucose-1-phosphate adenylyltransferase; Provisional.	0
NZ_AP022616.1\|WP_138249622.1\|2549695_2550619_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	2.747e-84
NZ_AP022616.1\|WP_138249627.1\|2556452_2557034_-\|DNA-3-methyladenine-glycosylase-I	gnl\|CDD\|377025	pfam03352, Adenine_glyco, Methyladenine glycosylase. The DNA-3-methyladenine glycosylase I is constitutively expressed and is specific for the alkylated 3-methyladenine DNA.	1.1302e-103
NZ_AP022616.1\|WP_138249618.1\|2542472_2543558_-\|DUF2236-domain-containing-protein	gnl\|CDD\|378343	pfam09995, DUF2236, Uncharacterized protein conserved in bacteria (DUF2236). This domain, found in various hypothetical bacterial proteins, has no known function. This family contains a highly conserved arginine and histidine that may be active site residues for an as yet unknown catalytic activity.	1.1321e-35
NZ_AP022616.1\|WP_138249624.1\|2552261_2552936_+\|isoprenylcysteine-carboxylmethyltransferase-family-protein	gnl\|CDD\|224931	COG2020, STE14, Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones].	3.40846e-21
NZ_AP022616.1\|WP_138249619.1\|2544413_2544842_-\|Sec-independent-protein-translocase-subunit-TatB	gnl\|CDD\|179538	PRK03100, PRK03100, Sec-independent protein translocase subunit TatB.	3.16086e-71
NZ_AP022616.1\|WP_061007153.1\|2546419_2546827_-\|RNA-polymerase-subunit-sigma-70	gnl\|CDD\|274904	TIGR03988, antisig_RsrA, mycothiol system anti-sigma-R factor. Members of this family are the anti-sigma-R factor RsrA, which contains a CXXC motif as a thiol-disulphide redox switch. It interacts with sigma-R. It regulates and is regulated by the mycothiol system, which occurs in many actinomycetes. [Transcription, Transcription factors].	6.11371e-05
NZ_AP022616.1\|WP_060999033.1\|2557030_2557336_-\|DivIVA-domain-containing-protein	gnl\|CDD\|274639	TIGR03544, cell_division_initiation_protein_DivIVA, DivIVA domain. This model describes a domain found in Bacillus subtilis cell division initiation protein DivIVA, and homologs, toward the N-terminus. It is also found as a repeated domain in certain other proteins, including family TIGR03543.	7.04557e-10
NZ_AP022616.1\|WP_135355546.1\|2544841_2546335_-\|trypsin-like-serine-protease	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	2.68576e-86

>NZ_AP022616.1|WP_138249651.1|2548135_2548747_+|O-methyltransferase
MVKHAERSITEEPITAATRERAEESGANPVTPAVGALLSVLAKIASAKAVVEVGTGAGVSGLWLLSGMREDGVLTTIDVEPEHQRLAKQAFVAAGVGPSRTRLIVGRAQEVLTRLADESYDLVFIDGEPADQPQFVAEGVRLLRSGGVIVVHRAALGGRAGDASANDRDVTAVREATRAIAEDERLTPVLVPLGDGLLAAVRD
>NZ_AP022616.1|WP_138249620.1|2546917_2547751_-|RNA-polymerase-sigma-factor-SigE
MHASVNDLQADSGLRQSPDIRGIGNIGLQAPVSADASCVNDAEPTELEIATTAMPAPTKLAPTHMSHVPVAEAELDWAEVSDELTGTAVFDATGDVATMPSWDELVRQHADRVYRLAYRLSGNPQDAEDLTQETFIRVFRSVQNYQPGTFEGWLHRITTNLFLDMVRRRTRIRMEALPEDYDRVPADDPNPEELYHDSRLGPDLQAALDSLPPEFRAAVVLCDIEGLSYEEIGATLDVKLGTVRSRIHRGRQALREYLASHPGDYSEAAAAISAKSA
>NZ_AP022616.1|WP_061007153.1|2546419_2546827_-|RNA-polymerase-subunit-sigma-70
MVDRGQLFRRAFSWLPAQFASQTDGPVGPRRFGSTEHLAIEAIAAFVDGELQMGAHLRAAHHLSQCPDCAAEVDAQGQARSALRDSCPIIAPTSLLGALANIPNDTSTQFADIQASGIEDRDFADRPPRERRRRR
>NZ_AP022616.1|WP_135355546.1|2544841_2546335_-|trypsin-like-serine-protease
MTNQDMSGDRPRLAPRPVTRTPVDPASQRAFGRPEGFAGSFLAEDQIRNQGEYTPTNQAPDPVLAEAFGRPGGGVDSLQRHPADAGALEAEGKDDDDAVADPWRDPSAAPSLGTPALPPPPPVVVAAPVGKLGVRDVLFGRKVSMTALAVLALLSLVIGILGGVVGRKTAEVVEAFTTSKVTLKTSDGGDLPEGRFAKVAAAVADSVVTIEAMGDTDGSQGSGVVVDGRGYVVTNNHVISDAAKNPSQYHISVVFNDGKQVPANLVGRDPKTDLAVLKVDNVDNLTVAKFGDAEKVKVGDEVIAAGAPLGLRSTVTHGIISALHRPVPLSGEGSDTDTVIDGIQTDASINHGNSGGPLINMNSEVIGINTAGKSLSDSASGLGFAIPVNEVKATVEILIKDGKIFHPTLGLNAKSASDKVASGAQVVNVVAGSPAEKGGIVENDVVVKVGNRKVADADEFVVAVRQLQIGQPAPIEVIRDGRHVTLTVVPNADTPAS
>NZ_AP022616.1|WP_138249619.1|2544413_2544842_-|Sec-independent-protein-translocase-subunit-TatB
MFGNIGWGEMLVLVIAGLVILGPERLPGAIRWTAGSLKQVREYLSGATSQLRQDLGPEFEDLRQPLSELQKLRGMTPRAALTKHLLDGDDSFLTGAFDTPAPPDQAKPLTTPEVNGIPPTPGAARAAPQPQSGTTQFDPDAT
>NZ_AP022616.1|WP_167526462.1|2543761_2544400_+|TetR-family-transcriptional-regulator
MDAALVVIEQHGPQTSTEQIAAHVGVSRTKLYRHFVDAADLQREVAHRTAQMITAELAPVWQPEGSMAQIVKAGVSAHVHFLTQHPNLYRYLQRCSIDEGFNAFADIKITIANLLTAVLKVYVAAFDVQADAERLSYSIVGLVETAAGHWLEQPLRDTQDALVADLTRWIWLMLDDSLRAGGVYLAADEILPPAAEIAANSDRYRDPARLPA
>NZ_AP022616.1|WP_138249618.1|2542472_2543558_-|DUF2236-domain-containing-protein
MDAVATFRRVAGLPVTDTELTPAVDYGFFGPDSVTWRVWSYPTSLLLGFARAVTIEHLDPYLAAAVDASGQVYARTRLRYDRTMQYFALVAFGDAEAVLDASEILVKIHGKAIGTEPITGKPFDANDPYSQLWIHLTAWHSILYTYEMFGPGKLTEAEELQYWEECARAAEFQTINPDDVPRTREGIQQYFEQYRPQMAGSEVAQNMMNYLVDLGYHILPERVPSWMRRVFNWPMRRAIIATMPKWMRTLGGIPQNYSDDVAAKLIARPLLRAVASVPRLELAILDFTTPHTTPIVGPTLMKIPAQNPVTYTPAEARKKWGRTTPFEQYQALVAKRALGKGPKPYEHNHSDALLEFEAHAG
>NZ_AP022616.1|WP_138249617.1|2540739_2542431_-|aldehyde-dehydrogenase-family-protein
MTDIAYTALVDQALDELAEGEKAWAATPLARRRQILDDVQQLAVQHGAEWVEAAIRIKQLNPESPLVGEEWISGPYPLAAGAAALSASLAKLEAGKSPLDGATFGTAAGRTTVNVLPLNVFDKLLLSGFSAQVWLQPGVSRDEAIRTAGLAQRDPGKTNGIGAVLGAGNITSIAPLDTIYELIAGNRVVALKLNPVTDPLLPVLTKVLAPFIALGAVRILTGGADVGTYLVQHDAVDHVHMTGSALTHDAIVFGVGEEGARRKAAGEPILHKDITSELGGVSPTIVVPGKWSKADIVFQANHIATQRLHNNGYNCVASQVVVLSSKWAQRDEFVAALTKALAAAPNRAAYYPGSDSRVASAEATYPKAQRLGDRVLVVDPEDRTALLNTEYFAPVYGVVDLDSDGVEFVRAATRLANEDFVGTLGVNIVAAPATIKALGKAFDAMIESLHYGTVAVNAWTGVGYLTPHATWGAFPGHTLSDVQSGIGVVHNGFLLEKPERTVVRGPFRPSPRSLIGGELSISPKPPWFVNNRTAASTGRLLTAFTGKPSWAKLPAIFVSALRG
>NZ_AP022616.1|WP_064857794.1|2540118_2540670_+|TetR/AcrR-family-transcriptional-regulator
MVSRILDAGRTVLIQHGYDGTTTNLIAKEADISPGSLYQYFPNKDVIIAAIVDDYTDEIARTVTTHLVEHVGKPAKLDTMRQTLAVLLDAMSEQPELLRAMIEHTPRLGLGNKIVDFEQRVGELALAHLQLRDQRPEHPNTVVWIAVRAVEHLTIRYVLDQPPIDHDEFLDELTALFGSYVSL
>NZ_AP022616.1|WP_167526387.1|2538374_2538599_-|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein
MAQDESVLEALLAAGVRVDSMCHNGLCGTCQTRVLSGDIDHRDSFLSDEERAAGRFMMPCVSRAVGGADIVLDL
>NZ_AP022616.1|WP_138249621.1|2549045_2549699_+|TetR/AcrR-family-transcriptional-regulator
MRSVEDLTTVARIRDAAIEQFGQHGFSASVRSIAAAAGVSAALVIHHFGSKDKLREACDAYVIETVRAAKTESMQNASPSAWFAQIAEIESFAPMTAYLMRALQTGGDLAKSLWQSMIDNAEGYLEEGVRAGTLKPSRDPKARARFLALTGGGALLTYIQLHPNPTDYRQVLHDYAQDMLLPALELYTEGLMADRAMYEAFMAQREAGQPIVTTTEE
>NZ_AP022616.1|WP_138249622.1|2549695_2550619_+|ABC-transporter-ATP-binding-protein
MNVNAAIEIDTLTKNFGAVRALDGLNLRVEHGEVHGFLGPNGAGKSTTIRILLGLVRADSGSVRLLGGDPWTDSVALHRHIAYVPGDVTLWPTLTGGETIDLLARMRGGIDEKRRAELTERFDLDPTKKTRTYSKGNRQKVSLVSAFASNADLLLLDEPSSGLDPLMENIFQQCVAEAAARGTTVLLSSHILAETERLCQRVTIIRAGRTVETGTLESMRHLSSTTIKADMINNPGRIDHLPGVSDIFFDGRMLTARVESESLGAVIKALGDAGVRSLVSQPPTLEDLFLRHYDNGRARREPEQVRA
>NZ_AP022616.1|WP_138249623.1|2550615_2552253_+|ABC-transporter-permease
MTAILDRPARPARPAAGASSFTGTLGLLRLYLRTDRIVLPLWVLLLSLPLSTVYIGSIEAVYPTAAARAGFAASIMASPAQRAIYGNIYNDSLGAAGIWKAGMFHVLIAVAVILTMIRHTRADEEAGRTELIDSTAVGRNASLTAALLLTGGGSVLTGLLGFLGLLNTDVPVTGSLAFSCALAASGLVFTAVAAVATQLSASARVARGTAFGVLGAAFTLRAVGDASGSELSWASPLGWSLLVRPYAGDRFGVLALHVTLTVALVVLAYQLQGGRDVGAGMFAERRGRPRANGMLHGPTGLAWRLTRGSVLVWTVGLGLYGLLVGSVVHGIGDELGGSGSARDIITRLGGTSALEEVFIAIAFNMLGMVAAAFAVSLALRPHQEETGQRAETLLAGALSRIHWLTGYLTIALAGTTVAMLTSGLLAGVTYGAAADDITGKLPLVLGSAAVQLPAIWLLIAVTTVLFGVMPRFTPVAWGALVGFIAVFLLGSLANSPHWVLDLDPFSHIPRVGSGSFTATPLVWLLVLDAILITLGALAFRRRDLR
>NZ_AP022616.1|WP_138249624.1|2552261_2552936_+|isoprenylcysteine-carboxylmethyltransferase-family-protein
MKLALQALASAAGGIVFFAVLLCVPAGTIHYWQAWVFIAVFMIATMGPSMYLAVKHPEALARRMHGGPKAETRPVQKVAIWAILASVVGTGVVSALDWRFGWTHVPTAVVVLGNVVVGVSLIAAQWVVIQNNFAGASISVEADQPVISTGLYGIVRHPMYICALIMMLATPLALGSYWGLIPVLAAAPALIARIFDEEKMLRVELPGYLDYTRKVRYRLVPYVW
>NZ_AP022616.1|WP_138249625.1|2553008_2553593_+|DUF4126-domain-containing-protein
MELFTGLGLATASGLNAYIPLLAMGLLGRFTNLVELPHPWAWLTNGWVIGIVAVLLVVEVVADKVPALDSINDTIQTFVRPTSGGIVFGSGTAAQTAAVTDPGAFASSGQWIPVVIGAVTALVVSLTKSTVRPVANVATGGLAAPVLSTVEDIASVGLVILAIVLPVLVVVALALLVWAAVAVLRRRKRRDAAA
>NZ_AP022616.1|WP_061010717.1|2553668_2554883_-|glucose-1-phosphate-adenylyltransferase
MREQPQVLGIVLAGGEGKRLYPLTADRAKPAVPFGGAYRLIDFVLSNLVNARYLRICVLTQYKSHSLDRHISQNWRLSGLAGEYITPVPAQQRLGPRWYTGSADAIYQSMNLIYDEDPDYIVVFGADHVYRMDPEQMVRFHIESGAGATVAGIRVPRAEASAFGCIDADESGRIRSFIEKPSDPPGTPDDPEQTFVSMGNYVFTTKALIDAIRVDAENHDSDHDMGGNIIPQMVADGMAAVYDFNDNEVPGATERDHGYWRDVGTLDAFYDAHMDLVSVHPVFNLYNRRWPILGESEHLAPAKFVNGGSAQESVVGAGSIISAASVRNSVLSSNVVIDDGAIVEGSVIMPGARVGRGAVVRHAILDKNVVVGPGEMVGVDLEKDRERFSVSAGGVVAVGKGVWI
>NZ_AP022616.1|WP_138249626.1|2554960_2556130_+|glycogen-synthase
MRVAMMTREYPPEVYGGAGVHVTELVGQLTKLCDVDVHCMGVHRRDAFVAQPDPLLAGANAALTTLSADLAMVNNAFAGPAAMPDVVHSHTWYTGMAGHLTALLHGIPHVLTAHSLEPRRPWKAEQLGGGYRISSWVERTAIEAADAVIAVSAGMRTDVLATYPQLDPARVHVVRNGIDTDDWYPVEAGQTLVDLGIDPDRPIAAFVGRITRQKGVGHLIAAAHQFDPDVQLVLCAGAPDTPEIAAEVAAAVKELSATRAGVHWIQEMLPLEKIREILATATVFVCPSVYEPLGIVNLEAMACGTAVVASDVGGIPEVVDDGTTGLLVHYDAEDAVGFETGLADAVNAVVRNPEQARTFGQAGRRRCIEEFSWMQVAQQTLDIYRSVCG
>NZ_AP022616.1|WP_073697662.1|2556131_2556332_-|DUF3117-domain-containing-protein
MRSGRVRREHPMAAMKPRTGDGPLEATKEGRGIVMRVPLEGGGRLVVELTPDEAAALGDELKNVTS
>NZ_AP022616.1|WP_138249627.1|2556452_2557034_-|DNA-3-methyladenine-glycosylase-I
MTAVEQTRCGWVDIGDTADAVLYRDYHDTEWGRPLRGTQALFERVSLEAFQSGLSWLIILRKRENFRAAFHGFDVATVAGFGEKDIDRLLADPGIVRNRAKIEATIANARVIDGGLDLDELLWSFAPPSRPRPADLAQVPATTPESVAMAKELKRRGFRFVGPTTAYALMQATGMVDDHVEACWVPRHSLSEA
>NZ_AP022616.1|WP_060999033.1|2557030_2557336_-|DivIVA-domain-containing-protein
MTLILIYLVVLILVAVVLFALGTVLFGRSEQLPPLARGTTATVLPASGVTGADVDAVKFTQTLRGYKTSEVDWVLDRLAQELDSLRGELTTLRAQTADAEQ

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Crispr_ID: NZ_AP022616_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022616_3

3373549-3373644

Orphan

Consensus_repeat	Method
GCAGGGCCCTCCCTACTCGGCCTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022616_3

>merge|NZ_AP022616|3|3373549-3373644|CRISPRCasFinder
GCAGGGCCCTCCCTACTCGGCCTTTCAGGCCCTGGTCGCAGACTCAACACCGTCCCCCGTTGACCCTGCGCGCAGGGCCCTCCCTACTCGGCCTTT

>NZ_AP022616|3|3|3373549-3373644|CRISPRCasFinder
GCAGGGCCCTCCCTACTCGGCCTTT	CAGGCCCTGGTCGCAGACTCAACACCGTCCCCCGTTGACCCTGCGC
GCAGGGCCCTCCCTACTCGGCCTTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022616.1\|WP_135356793.1\|3386375_3388145_-\|type-VII-secretion-AAA-ATPase-EccA	unknown	unknown	gnl\|CDD\|188437
NZ_AP022616.1\|WP_138247735.1\|3377311_3378211_-\|ESX-secretion-associated-protein-EspG	unknown	unknown	gnl\|CDD\|379414
NZ_AP022616.1\|WP_082762052.1\|3367332_3368283_+\|sulfate-adenylyltransferase-subunit-CysD	unknown	unknown	gnl\|CDD\|235375
NZ_AP022616.1\|WP_135356754.1\|3380809_3384799_-\|type-VII-secretion-protein-EccCa	unknown	unknown	gnl\|CDD\|274858
NZ_AP022616.1\|WP_061001055.1\|3366583_3367384_+\|sulfotransferase	unknown	unknown	gnl\|CDD\|286169
NZ_AP022616.1\|WP_138247740.1\|3370582_3371344_-\|trans-aconitate-2-methyltransferase	unknown	unknown	gnl\|CDD\|184509
NZ_AP022616.1\|WP_061000613.1\|3378234_3378522_-\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|227179
NZ_AP022616.1\|WP_138247738.1\|3372304_3373540_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_AP022616.1\|WP_061001057.1\|3364327_3365047_+\|CoA-pyrophosphatase	unknown	unknown	gnl\|CDD\|239518
NZ_AP022616.1\|WP_064860575.1\|3380501_3380810_-\|PE-family-protein	unknown	unknown	gnl\|CDD\|376422
NZ_AP022616.1\|WP_138247741.1\|3370374_3370581_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022616.1\|WP_138247749.1\|3375924_3377304_-\|type-VII-secretion-integral-membrane-protein-EccD	unknown	unknown	gnl\|CDD\|274855
NZ_AP022616.1\|WP_061001058.1\|3363815_3364301_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022616.1\|WP_138247736.1\|3374545_3375925_-\|type-VII-secretion-associated-serine-protease-mycosin	unknown	unknown	gnl\|CDD\|274856
NZ_AP022616.1\|WP_138247739.1\|3371395_3372295_+\|amidohydrolase	unknown	unknown	gnl\|CDD\|368185
NZ_AP022616.1\|WP_061001056.1\|3365147_3366521_+\|sulfatase	unknown	unknown	gnl\|CDD\|293751
NZ_AP022616.1\|WP_138247742.1\|3368314_3370165_+\|adenylyl-sulfate-kinase	unknown	unknown	gnl\|CDD\|180120
NZ_AP022616.1\|WP_163693169.1\|3378919_3380488_-\|PPE-domain-containing-protein	unknown	unknown	gnl\|CDD\|366325
NZ_AP022616.1\|WP_135356755.1\|3384795_3386379_-\|type-VII-secretion-protein-EccB	unknown	unknown	gnl\|CDD\|368288
NZ_AP022616.1\|WP_061010344.1\|3378564_3378858_-\|type-VII-secretion-protein-EsxS	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP022616.1\|WP_138247742.1\|3368314_3370165_+\|adenylyl-sulfate-kinase	gnl\|CDD\|180120	PRK05506, PRK05506, bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional.	0
NZ_AP022616.1\|WP_082762052.1\|3367332_3368283_+\|sulfate-adenylyltransferase-subunit-CysD	gnl\|CDD\|235375	PRK05253, PRK05253, sulfate adenylyltransferase subunit CysD.	0
NZ_AP022616.1\|WP_135356754.1\|3380809_3384799_-\|type-VII-secretion-protein-EccCa	gnl\|CDD\|274858	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa. This model represents the N-terminal domain or EccCa subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	0
NZ_AP022616.1\|WP_061001055.1\|3366583_3367384_+\|sulfotransferase	gnl\|CDD\|286169	pfam09037, Sulphotransf, Stf0 sulphotransferase. Members of this family are essential for the biosynthesis of sulpholipid-1 in prokaryotes. They adopt a structure that belongs to the sulphotransferase superfamily, consisting of a single domain with a core four-stranded parallel beta-sheet flanked by alpha-helices.	1.66908e-108
NZ_AP022616.1\|WP_138247740.1\|3370582_3371344_-\|trans-aconitate-2-methyltransferase	gnl\|CDD\|184509	PRK14103, PRK14103, trans-aconitate 2-methyltransferase; Provisional.	3.5956e-153
NZ_AP022616.1\|WP_061000613.1\|3378234_3378522_-\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|227179	COG4842, COG4842, Uncharacterized protein conserved in bacteria [Function unknown].	4.94154e-18
NZ_AP022616.1\|WP_138247738.1\|3372304_3373540_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	4.00252e-09
NZ_AP022616.1\|WP_061001057.1\|3364327_3365047_+\|CoA-pyrophosphatase	gnl\|CDD\|239518	cd03426, CoAse, Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative stress. CoAse has a conserved Nudix fold and requires a single divalent cation for catalysis. In addition to a signature Nudix motif G[X5]E[X7]REUXEEXGU, where U is Ile, Leu, or Val, CoAse contains an additional motif upstream called the NuCoA motif (LLTXT(SA)X3RX3GX3FPGG) which is postulated to be involved in CoA recognition. CoA plays a central role in lipid metabolism. It is involved in the initial steps of fatty acid sythesis in the cytosol, in the oxidation of fatty acids and the citric acid cycle in the mitochondria, and in the oxidation of long-chain fatty acids in peroxisomes. CoA has the important role of activating fatty acids for further modification into key biological signalling molecules.	1.45678e-40
NZ_AP022616.1\|WP_064860575.1\|3380501_3380810_-\|PE-family-protein	gnl\|CDD\|376422	pfam00934, PE, PE family. This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.2034e-10
NZ_AP022616.1\|WP_138247749.1\|3375924_3377304_-\|type-VII-secretion-integral-membrane-protein-EccD	gnl\|CDD\|274855	TIGR03920, T7SS_EccD, type VII secretion integral membrane protein EccD. Members of this family are EccD, a component of actinobacterial type VII secretion systems (T7SS) with ten to eleven predicted transmembrane helix regions. [Protein fate, Protein and peptide secretion and trafficking].	1.12334e-54
NZ_AP022616.1\|WP_138247736.1\|3374545_3375925_-\|type-VII-secretion-associated-serine-protease-mycosin	gnl\|CDD\|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	7.99586e-95
NZ_AP022616.1\|WP_138247739.1\|3371395_3372295_+\|amidohydrolase	gnl\|CDD\|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	4.80584e-30
NZ_AP022616.1\|WP_061001056.1\|3365147_3366521_+\|sulfatase	gnl\|CDD\|293751	cd16027, SGSH, N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase). N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.	8.85599e-141
NZ_AP022616.1\|WP_138247735.1\|3377311_3378211_-\|ESX-secretion-associated-protein-EspG	gnl\|CDD\|379414	pfam14011, ESX-1_EspG, EspG family. This family of proteins contains the the EspG1, EspG2 and EspG3 proteins from M. tuberculosis. These proteins are involved in the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis which is important for virulence and intercellular spread. Proteins in this family are typically between 254 and 295 amino acids in length.	1.22355e-38
NZ_AP022616.1\|WP_163693169.1\|3378919_3380488_-\|PPE-domain-containing-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.03397e-55
NZ_AP022616.1\|WP_135356755.1\|3384795_3386379_-\|type-VII-secretion-protein-EccB	gnl\|CDD\|368288	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B. EccB is a family of largely Gram-positive bacterial transmembrane componenets of the type VII secretion system characterized in Mycobacterium tuberculosis, systems ESX1-5. Translocation of virulent peptides through the membranes is thought to be mediated via a complex that includes EccB, EccC, EccD, EccE, and MycP. EccB, EccC, EccD, and EccE form a stable complex in the mycobacterial cell envelope.	0
NZ_AP022616.1\|WP_135356793.1\|3386375_3388145_-\|type-VII-secretion-AAA-ATPase-EccA	gnl\|CDD\|188437	TIGR03922, T7SS_EccA, type VII secretion AAA-ATPase EccA. This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking].	0

>NZ_AP022616.1|WP_138247738.1|3372304_3373540_+|alpha/beta-fold-hydrolase
MNSPHGDAFNPPVPVPDVPGADATARGLPRRADLTWQQKLIVDSSAVADLGLRTALASVIGAGMIPRMAASAVRSRAGDDPDALRFYAELATTKDPQQCFPAPSRPPRVSTRPAGQVAQWVARGRVENIWFQSSYDAVYPGLRDRRSGYTRNNVVHAQHWRHDDGPRPTLCVIHGFMGSPYLFNGLFFSLPWFFRSGYDVLLYTLPFHGPRAEKGSPYSGYGFFMDGVPGFAEAMAQAVHDFRSVLDHLEHTGVDRVALTGMSLGGYTSSLIASVDDRIQAVIPNVPVVTPDRTVDEWFPANLLVKLSNRLAHTDEDLIATAGLYHSPLNYKPLVPKDRRLIIAGLGDRLAPPQQAEMLWEHWDRCAFHWFPGNHILHVSQPDYLRRMTKFMSPFMFDSSERQDGRARPAR
>NZ_AP022616.1|WP_138247739.1|3371395_3372295_+|amidohydrolase
MDESVRDLWQSLGLPGLIDVHTHFMPKNVMDKVWKYFDSAGPLTGRTWPIMYRTEEQHRLETLRGFGVLAFTSLVYPHKPDMAAWLNQWAAQFAAQTPDCLSTATFYPEPGAPDYVADAIAGGTRVFKAHVQVGAYHPADPLLDDVWGTIADAGVPVIIHCGSGPTPGVHTGPDQVRTVLDRHPSLKLIIAHLGMPEYREFLDLCEQFDGVHLDTTMAFTPFIEETMPFPPAELPRLAELGDRVLFGSDFPNIPYRYAESLEVLTKVAPDDDWLRKVLYHNAARLFDIDDRRTGAENRG
>NZ_AP022616.1|WP_138247740.1|3370582_3371344_-|trans-aconitate-2-methyltransferase
MWNPDTYLAFADHRGRPFYDLLARVGAQTPRRVADVGCGPGNLTVTLSERWPDAVIEAVDNSPEMVEAARARGVDARVVAAADWSPAPDTDVMVSNAVLQWVPEHRELLRRWVGQLPKGAWLAFQVPGNFDSPSHQAVREVARYPEFAEALADIRFRETNVVDDPAGYAALLTAAGCTVDAWETTYLHQLTGETPVLDWITGTALTDVRSRLTDDAWERYRQAIIPLLAQAYPPQPDGTTFFPFRRIFVVAQT
>NZ_AP022616.1|WP_138247741.1|3370374_3370581_+|hypothetical-protein
MSIVTRWVSYFIIVVGLTVAPGLIAIGLATSAHAAPNTGSISVHQIVAHQNSAPQPGTPVQHQYQQLH
>NZ_AP022616.1|WP_138247742.1|3368314_3370165_+|adenylyl-sulfate-kinase
MSTRQLLRIATAGSVDDGKSTLIGRLLHDTDSLPLDHLDAVTDDDGVADLAALSDGLREQGITIDVAYRFFSTEARSYILADTPGHERYTRNMFTGASNAHVAILLVDARAGVLRQTLRHARIAKLLGIKHFAAAVNKIDLVDFDQARFDAVHDELGQVAARLGAVDLTVIPLAAKLGDNVVHRSENTPWYEGPTLLEYLEGIELGAPQAEPAKLRLPIQWVSRPTAEQRRRYTGRLTAGTLQVGDTVLSLPAGTSSTVTAVDTLDDDRTTAVAPLSVSIELADDIDVGRGDVLVSSAENASVPVLARELDATVCWFAETPLRAGDRLALKQGTRTVRATVQALHTRLDPETLDDIDQPVELVLNDIGAVTLRTSSTVIADPYRDNRESGAFILIDETSNDTVGAGTITEPREVKLGTHSRSDIRWHHSSLDRSYRWARTGQRGATIWFTGLPASGKSTLAVAVERALVETGQVAYLLDGDNIRHGLSDDLGFSAGDRAENIRRVGHLARLLADSGVVALASLVSPLKSDRDTARELSTVAKLPFIEVYVSTPRSECERRDPKGLYARAKAGELRGLTGVDAPYEPPENPDLVVDTTGADIDTLVAQVLGALNTLR
>NZ_AP022616.1|WP_082762052.1|3367332_3368283_+|sulfate-adenylyltransferase-subunit-CysD
MGGALPRRSRKGRAAGMSIHVDELRLLEAEAVHIIREVVAELERPVLLFSAGKDSIVLLRLAEKAFRPGPLPFPVLHVDTGHNFPEVIDFRDRRTTGVGHKLLVGSVQESIDTGRVADPGPGASRNRQQTRTLLDALEAGGFDAAFGGARRDEERARAKERILSFRDEFGQWDPRAQRPEPWSLYNGRIRKGEQVRVFPLSNWTELDIWRYIELENLELPSIYFAHEREVFERDGILLAVSEYTQPGPGESAAVEWVRYRTVGDLTITGAVRSKAVDIASVIAEISAATVSERGETRADDRTSVAAMEDRKREGYF
>NZ_AP022616.1|WP_061001055.1|3366583_3367384_+|sulfotransferase
MTARTAYLVLASQRSGSTLLVESLRATGVAGEPQEFFQYLPHTSMSPQPREWFADTEDESILRLLDPLIDGRPELAPATIWRDYIQTAGRTPNGIWGGKLMWNQTAQLQRRAQGLPDRSGDGLLAAIRDVIGSDPVLIHIHRPDVVSQAVSFWRAVQTRVWRGRPDPVRDARAEYHAGAIAHVVRMLRAQEEGWQKWFLDENVNRIEVPYPVLWRNLTEVVGDVLEALGQDRRLAPTPVLERQADQRSDEWVERYRAEAEKEGLPV
>NZ_AP022616.1|WP_061001056.1|3365147_3366521_+|sulfatase
MPHTPGQNVLFVHWHDLGRYLGAYGHRDVRSPRLDQLAAEGTLFTRAHATAPLCSPSRGSIFTGRYPQSNGLVGLAHHGWEYHAGVQTLPQLLSESGWHTALFGMQHETSFPSRLGFDEYDVSNSYCEYVVEQALRWLEEPPQKPFLLTTGFFETHRPYPRERYEPAAGETVTVPDYLPDTDSVREDLAEFYGSIAVADAAVGQLLDALEARGLDRNTWVVFLTDHGPALPRAKSTLYDAGTGIAMVVRPPRDAGIEPHVYDELFSGVDLLPTLLELLGVPVPVEVEGFSHAQALTRSEAGSAVREEVYTAKTYHDSFDPIRAVRTKDFSYIENYASRPLLDLPWDIADSPPGRAVQPAISDPRPARELYDLHADPTERHNLLLDVQPEYHAVAAQLALKLNTWRQQTGDVIPSDFTGTQISDRYTRTYLSIHGRPATSRSAVASDRGINPDSTSQD
>NZ_AP022616.1|WP_061001057.1|3364327_3365047_+|CoA-pyrophosphatase
MTIPYDETLRAQIGTHLAGHRRRVVDDPSKRHAAVAIVLVDSERGEDRIDPAPVDEWIGGRPLPDQNLDGRMVDVAGGAAFLLCRRTSRLNSHAAQWALPGGRLDPGETVVDAALRELHEEVGIKLPDESVLGLLDDYATRSGYVITPVVMWGGGRLDPQPSPDEVLAVYRVGLHQLQRPDSPRFISIPESDRPVVQIPLGNDLIHAPTGAVLLQMRWLGLEGRPDPVDELEQPVFAWR
>NZ_AP022616.1|WP_061001058.1|3363815_3364301_+|hypothetical-protein
MAVLLRKLLGIGNLPDDIREQLQAEGLLHVAEFVPVTFRFSGHVPGKVAKGTLRSLVGALVITEKRLIGTLSSVPKKGAKTVNHMWDEPDGTMVRAELDESGLLLDAPDLSAVDPSFEGSMSLRYKTPLPADLLAALPARAFTFDVPNKYVYLACGMPPTT
>NZ_AP022616.1|WP_138247736.1|3374545_3375925_-|type-VII-secretion-associated-serine-protease-mycosin
MVAIRRGISVLTAAFAATAAVVPTVLVPAAGAIVPPHVDEHAAPPSGSVGPVAAMGQRGQCVTAGVLPGTDPGAPGPGHTLLNVPGAWAFSRGDGQTVAVIDTGVRPGPRLPNVEAGGDFVENTDGLTDCDGHGTLVAGLIAGQPGADGFSGVAPGARILAIRQTSERYAPRGNGGDPAAAYATIAVASLARAVVHAADRGAKVIAITAVTCLPADRPVDQTELGAALKYAAQEKDAVIVAAAGNDRAGLAGGPSCEANPLDNPGNAADPRNWAGVKSVSIPSWWQPYVLSVGSLDAAGQPSDFTTPGPWVGIAAPGENVASTGANGLANALPNERGDLFPLRSSSYAAAYVAGVAALVRSRFPALNAADVTHRLTATAHGAARSPSNLVGAGVVDPVAALTWDLPAIAPAPKSVAVAMPPEPAPKDTTPRTIAFTGAAVLAVAALIALVAYRRKDGAR
>NZ_AP022616.1|WP_138247749.1|3375924_3377304_-|type-VII-secretion-integral-membrane-protein-EccD
MPIVRVAVLAAGDEQGGRGRLTDVALPAGLPLREIVPAVRRIIAPEAASAAELSLAPLGGAAYSLDATLDTVGVVDGDLLALQPVPAGPPAPRIVEDIADAAAIFSAARENPWGNAHIRRLAAWGVVALTVLATALATLVRVRTGQPAGLFTVVGVAVLAVAAALLTRPAMPRLATALSLVALLPVGAAFALAVPGPSGPASLLLGAAAVAAWSIVSITVGGQAIAAFTATTVLGIAGVIVGAAASLWQLNNAVIGAVLIVFALLVMVQAAQLSTLWARFPVPNIPAPGDPTPSALPRSVLADLPRRVRVCDAHQTGFLAGAVLTLTAGSVVLVAAAHPSPWAWYVVVAAALATALRARIWDSVPCKVWLLSQPYLLAAVLLTLFACGGHYTNAWWSLAALAALVAVGVVAALNPQVADPQTYSLPMRRLVGFAATALDASLIPVLAYLVGLFAWVINR
>NZ_AP022616.1|WP_138247735.1|3377311_3378211_-|ESX-secretion-associated-protein-EspG
MSHDTERAGVPVSAVELTAEQAWFLADRLGAGGFPWVLAITQPYSDPAAKNGFDADQVTALTRMGVLSADGSVHPAVAQWIRAVCRPRRWLELRWVSGSGAMLRGILVRSGDLTVAVLRSEHLMTCSALTVASPDALVPVLTAGLSGRAPARFDEFAMPAHIGAKADERLRRGDSLDDVMDHLGVPPSAHTVVRAAFAPGRSYVEIVAGDHRDGHRISTDVGVSIVDTAAGRVVVAPVKAADGTWISNFTPGTDLAVTAAVQRLTATLPDGPWFPTANLTRDFETSTGERKEHVPQHVW
>NZ_AP022616.1|WP_061000613.1|3378234_3378522_-|WXG100-family-type-VII-secretion-target
MSQIMYNYPAMLAHAGEMTAYAGALHAVGLDIASEQAALAGAWQGDTGTSYQAWQAQWNTAMEELVHAYRAMASTHETNTLSMSARDSAEGAKWV
>NZ_AP022616.1|WP_061010344.1|3378564_3378858_-|type-VII-secretion-protein-EsxS
MSMLDAHIPQLIASESTFSAKAALMRSTIGQAEQAAQSAQGFHQGDSAAAFQAAHVRFMAVAAKVNALLDIAQANLGDAAGTYVAQDTAAAGTYTSV
>NZ_AP022616.1|WP_163693169.1|3378919_3380488_-|PPE-domain-containing-protein
MGIGLPTAPIWAALPPEVHSTLLSSGPGPGSLLAAAAAWQSLSTEYASAAAELTALLGEVQAGAWEGPSAEQYLASHAPYLTWLAQASANSAANAVQHETAAAAYSTALAAMPTLPELALNHVVNAALVATNFFGINTIPIALNEADYARMWLQAATVMGTYQAVSGAAVAAAPTTTPAPMMLAAGVGEAGTASASATQAGAQLQAADAGSSLDASNAITDYLYNYIKTLPGGDLIWKFLQDPLGQIQQMIFDFLTNPSQALTTWGPLLFALGYQAFFQPVGWGTWGAMLSAPLWGPALIAVGLSSLGLLALLEPDYVPDPEVADAFPPPPQLQAVDHQMPVVSVAPTVPATPASPASAPAPAPTSVAAPAPAAPAPLMAYAVAVDDPGPGFTPTLRDGATAPAPASGIAAAAAAAAAAAATERRRARRRRAAKERGVRDEYMDMNSEVDPDFGDGAGADRTPRADVLASARGAGPIGFSGTLTRQDQQATGLNRLTGNGFGGGVTEPMLPGSWDAEGGANR
>NZ_AP022616.1|WP_064860575.1|3380501_3380810_-|PE-family-protein
MTLRVVPEGLTAAGAAVEALTARLAAAHAAAAPAVTAVIPPAADPVSLQTAISLSAHGAEHEAVAAQGVTELGRAGGGVTEAGISYATGDAEAAATYVTVLG
>NZ_AP022616.1|WP_135356754.1|3380809_3384799_-|type-VII-secretion-protein-EccCa
MSRLIFEARRRLPVPATRASVITIEPPPELPRLVPPSLLRRVLPYLIVILIVGMVVALVATGMRVISPQTLFFPFVLLLAATAFYRGSDNKTRTEEVDAERADYLRYLSVVRDNVRAQAAEQRAALEWSHPAPDQLAAIAGTRRQWERDPHDADYLVVRAGLHDARLETVLQVKDTAAEIDLEPVSHSALRGLLDVQRTVPAVPGGIDLTKVSRITVLGDANEVRGALRAWIAQAVTWHDPALLGIGLATADAETLESESWSWLKWLPHSDIPGQIDGVGPARYLSADVPELAGLLSAELGDRQPFGAADTTPQRHLLIVVDDPDADLGELLPRAGLAGVTVLQRGTEQPEYPDPDRPVLRVSDRRIERWAAAGWQSYFDVADDLSPHAAAHLARGLARWDSNPNRARSTGAGLATFGTLLGIPDAAALDVAGLWAPRSRAEELRVPIGVTATGEPLMFDLKDEAEGGMGPHGLMIGMTGSGKSQTLMSILLSLLTTHSADRLIVIYADFKGEAGADIFRGFPQVVAVISNMAEKRSLADRFADTLRGEVARREQLLMEAGRRVQGSAFNSVLEYEAAQAAGHDLPPIPTLLVVADEFSLMLADHPEYAELFDYVARKGRSFRIHILFASQTLDVGRIKDIDKNTSYRIGLKVASPSISRQIIGVEDAYHIEAGPEHKGEGFLVPTPGAVPVKFRSTYVDGIYDPPRAEKAVVVHAVPQPQLFPAGHVTPAPDTVIVTDTAPDLRPPRKLVATIGEQLAQYGPQAPRLWLAPLDEPIALPELLAGTEIPAGHGRWPLGEIDRPFQMRRDPLVFDATSAAANLVIHGGPKSGKSTALQTFVLSAAATHSPRAVTFYCLDYGGGGLRSLKPLAHVGSVASPLEPERIRRTFGELEQLLASRQARAAAGDGDLRDDGYGDVFLVIDNLYAFSRDNTDMFNTRNPLLSKMTELVNTGMAYGIHVVITTPNWLEVPLAMRDGLGLRLELKLADSRDSNVRSTGTPGVAALTRPADGVPADQPGRGLTMAAEHFLFAEPDLGAIAAINARYPGQTAPPVRLLPTDLAPETLAPLYHSPETVVIGQREQDLAPVTVDFAANPLLMVLGDAKSGKTTLLRHLIRTVRDNSTPESVAFTVIDRRLHLVDEPLFPDNEYTPNVDRVTPAMLGLAALLEKRRPPAGLTAAELSGWTYRNGQGNHLHYLIIDDVDQIPDAPAVSGPFVGQRPWTALLGLLSQASELGLRVIVTARAAGSAHAVMTAPLLRRLNELQATTVMLSGNPQDSGRIRGHRFNRLPAGRAMVLGDSDEATYVQLINPLVADPITGRPTGTQRGEFH
>NZ_AP022616.1|WP_135356755.1|3384795_3386379_-|type-VII-secretion-protein-EccB
MTDRKSFSSRTPVNENPDQIHYRRGFVTRHQVSGWRFLMRRIASGVAMHDTRMLVDPLRTQSRSVLVGGLVLVTALAGCFVFSLIRPAGVAGNDVILADRETSALYARVGDQLHPVLNLTSARLIAGRPDNPTMVPSAELDKFARGSLIGIPGAPERMVPNSSRDADWTVCDAATGEVVGVTVITGPLAEGGSRAGALGAHDAVLVRNDGVGSAGVNGGSWLLWDGRRSAVDLNNRAVTAALGLGANGTALPTPRAVADGLFNAIPESAPLAAPPIVNAGQPTPYPMPVAAPVGAVVTAVTTEAATDNAVRYYAVLDDGLQPISQVVAAILRNTDSYGLEQPPRLSADQVARIPVSTAINTAAYPERPLAVVDATKAPLTCARWTKHDGATTNSLTLLAGATLPLPADEHTVALAGPAGTAQRVAVTPGTGYYVQATGQGGTPALSGYWISDTGVRYGISTEGDATNADRKTPAALGLTAAPLPVPWSILSQFAPGPTLSRSDALQIPALVPTRTSPAVEIAVRENP
>NZ_AP022616.1|WP_135356793.1|3386375_3388145_-|type-VII-secretion-AAA-ATPase-EccA
MLTRFATGCLALGLSVDGRRRPADLDAALGGFLTLTRIAGEHCDAWTGLAAAGAATPDVVEAIWRTVASAGVLQRALDLADGDLGFTYDSGLYLQFRAADRDGFQLAYAATLAGAGAYEGADQLVGELLDRKPGWLPARWVRVGMHHRTRRWSDVVRQLTPIVNDPNLDPNYAHAARVALGIALAHLGMFAPALSHLEDPEGPVAVAAVDGTFVKALSLRAQGEDDEATDVLAELYAAHPDNTDAEHALTDTSFGIDPTTAARIEARHNPWDPETEPTEADFVDPDAKSRKAHLLVEAEAELAEFIGLEEVKYQVARLKSSVAMSIRRQERGLAVAQRTNHLVFAGPPGTGKTTIARVVAKIYCGLGLLRKETVREVHRADLIGQHIGETEAKTNAIIDSALDGVLFLDEAYALVSTGAKNDFGLVAIDTLLARMENDRSRLVVIIAGYRKDLDMFLDTNEGLRSRFTRSIDFPSYSATELTEIAMRMAEKRDSVFEPAAQQEMEQLFGHLATATTPDAAGVARRSLDIAGNGRFVRNLVERSEEEREYRLDHLAAHDFTDDELMTITASDVSNSAAPLLRGLGLVVPQ

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Crispr_ID: NZ_AP022616_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022616_4

3892248-3892364

Orphan

Consensus_repeat	Method
GGCTCGGGTACGGGAGCCGGGCTGTGGGCGGGCTTGCTCGCCGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022616_4

>merge|NZ_AP022616|4|3892248-3892364|CRISPRCasFinder
GGCTCGGGTACGGGAGCCGGGCTGTGGGCGGGCTTGCTCGCCGGCACCGACTCGGCCGTGGGGCGCGGCGCTGGCTCGGGTGCGGGAGCCGGGCTGTGGGCGGGCTTGCTCGCCGGC

>NZ_AP022616|4|4|3892248-3892364|CRISPRCasFinder
GGCTCGGGTACGGGAGCCGGGCTGTGGGCGGGCTTGCTCGCCGGC	ACCGACTCGGCCGTGGGGCGCGGCGCT
GGCTCGGGTGCGGGAGCCGGGCTGTGGGCGGGCTTGCTCGCCGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022616.1\|WP_138251249.1\|3883851_3884274_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022616.1\|WP_138251237.1\|3897620_3898271_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_AP022616.1\|WP_138251244.1\|3890108_3890582_-\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176854
NZ_AP022616.1\|WP_138251273.1\|3900127_3900553_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|379275
NZ_AP022616.1\|WP_138251238.1\|3897278_3897500_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022616.1\|WP_163692878.1\|3896374_3897271_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022616.1\|WP_138251276.1\|3884253_3885612_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_AP022616.1\|WP_138251247.1\|3888005_3888674_+\|DinB-family-protein	unknown	unknown	gnl\|CDD\|378981
NZ_AP022616.1\|WP_138251250.1\|3883655_3883844_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022616.1\|WP_138251241.1\|3893585_3894953_+\|NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|224152
NZ_AP022616.1\|WP_064858884.1\|3901763_3902651_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022616.1\|WP_138251243.1\|3890682_3891285_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_AP022616.1\|WP_167526472.1\|3887197_3888007_-\|SMP-30/gluconolactonase/LRE-family-protein	unknown	unknown	gnl\|CDD\|369882
NZ_AP022616.1\|WP_138251274.1\|3894956_3896321_-\|AarF/ABC1/UbiB-kinase-family-protein	unknown	unknown	gnl\|CDD\|270872
NZ_AP022616.1\|WP_053854963.1\|3900558_3901581_-\|dehydratase	unknown	unknown	gnl\|CDD\|184249
NZ_AP022616.1\|WP_138251245.1\|3889431_3890058_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_AP022616.1\|WP_138251275.1\|3885766_3887083_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NZ_AP022616.1\|WP_163693182.1\|3888657_3889275_-\|DUF1345-domain-containing-protein	unknown	unknown	gnl\|CDD\|377769
NZ_AP022616.1\|WP_138251236.1\|3898267_3898825_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372807
NZ_AP022616.1\|WP_138251235.1\|3898821_3899928_-\|DUF2236-domain-containing-protein	unknown	unknown	gnl\|CDD\|378343

Protein	Function_ID	Function_description	E-value
NZ_AP022616.1\|WP_138251237.1\|3897620_3898271_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.17445e-10
NZ_AP022616.1\|WP_138251244.1\|3890108_3890582_-\|SRPBCC-family-protein	gnl\|CDD\|176854	cd07812, SRPBCC, START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket; they bind diverse ligands. Included in this superfamily are the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, and the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), as well as the SRPBCC domains of phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of this superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	1.35222e-16
NZ_AP022616.1\|WP_138251273.1\|3900127_3900553_+\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|379275	pfam13577, SnoaL_4, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	1.465e-24
NZ_AP022616.1\|WP_138251276.1\|3884253_3885612_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	2.5421e-48
NZ_AP022616.1\|WP_138251247.1\|3888005_3888674_+\|DinB-family-protein	gnl\|CDD\|378981	pfam12867, DinB_2, DinB superfamily. The DinB family are an uncharacterized family of potential enzymes. The structure of these proteins is composed of a four helix bundle.	1.84792e-06
NZ_AP022616.1\|WP_138251241.1\|3893585_3894953_+\|NAD(P)-binding-protein	gnl\|CDD\|224152	COG1231, COG1231, Monoamine oxidase [Amino acid transport and metabolism].	5.66671e-66
NZ_AP022616.1\|WP_138251243.1\|3890682_3891285_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	7.07002e-06
NZ_AP022616.1\|WP_167526472.1\|3887197_3888007_-\|SMP-30/gluconolactonase/LRE-family-protein	gnl\|CDD\|369882	pfam08450, SGL, SMP-30/Gluconolaconase/LRE-like region. This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyze diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.	7.42727e-38
NZ_AP022616.1\|WP_138251274.1\|3894956_3896321_-\|AarF/ABC1/UbiB-kinase-family-protein	gnl\|CDD\|270872	cd13970, ABC1_ADCK3, Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3. This subfamily is composed of the atypical yeast protein kinase Abc1p, its human homolog ADCK3 (also called CABC1), and similar proteins. Abc1p (also called Coq8p) is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is necessary for the formation of a multi-subunit Q-biosynthetic complex and may also function in the regulation of Q synthesis. Human ADCK3 is able to rescue defects in Q synthesis and the phosphorylation state of Coq proteins in yeast Abc1 (or Coq8) mutants. Mutations in ADCK3 cause progressive cerebellar ataxia and atrophy due to Q10 deficiency. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Subfamily 13 (ABC1K13) of plant ABC1 kinases belongs in this subfamily with yeast Abc1p and human ADCK3. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.	6.12533e-95
NZ_AP022616.1\|WP_053854963.1\|3900558_3901581_-\|dehydratase	gnl\|CDD\|184249	PRK13693, PRK13693, (3R)-hydroxyacyl-ACP dehydratase subunit HadB; Provisional.	4.11951e-58
NZ_AP022616.1\|WP_138251245.1\|3889431_3890058_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	9.34722e-07
NZ_AP022616.1\|WP_138251275.1\|3885766_3887083_-\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	3.62673e-161
NZ_AP022616.1\|WP_163693182.1\|3888657_3889275_-\|DUF1345-domain-containing-protein	gnl\|CDD\|377769	pfam07077, DUF1345, Protein of unknown function (DUF1345). This family consists of several hypothetical bacterial proteins of around 230 residues in length. The function of this family is unknown.	2.85931e-54
NZ_AP022616.1\|WP_138251236.1\|3898267_3898825_-\|hypothetical-protein	gnl\|CDD\|372807	pfam13911, AhpC-TSA_2, AhpC/TSA antioxidant enzyme. This family contains proteins related to alkyl hydro-peroxide reductase (AhpC) and thiol specific antioxidant (TSA).	1.81086e-14
NZ_AP022616.1\|WP_138251235.1\|3898821_3899928_-\|DUF2236-domain-containing-protein	gnl\|CDD\|378343	pfam09995, DUF2236, Uncharacterized protein conserved in bacteria (DUF2236). This domain, found in various hypothetical bacterial proteins, has no known function. This family contains a highly conserved arginine and histidine that may be active site residues for an as yet unknown catalytic activity.	1.06167e-32

>NZ_AP022616.1|WP_138251243.1|3890682_3891285_+|TetR/AcrR-family-transcriptional-regulator
METGGQVDGRRVRGDATRRKVAREAAMIATTHGLDSITVGTLAAATGVSKSGILTVFGNREAIQVAAVVEARNIYREAVLAKVYEAAPGAPRLRALIESWVDYLRAGVFPGGCFIAATSAEYGRRDGPVADEVRKLKRGWLALLETELTAAGSPNPAVDAFKIDAFLNAGNTRREVFADDAELLCAKELAMNVVDQLPSG
>NZ_AP022616.1|WP_138251244.1|3890108_3890582_-|SRPBCC-family-protein
MTTNPQPALEDSIDITAPPTAVWSLVSDVRRMADWSPQVESTRLRNGAVEVAQGVEFTNLNTNGTFQWMTHGTVMRFDTGREIAFRIEENWAVWSLHLEPSPDGGTRLTQRRESPDGSPEQTVQVIDSYLGGQAAFTESMRDGMRQTLQAIKVAAEK
>NZ_AP022616.1|WP_138251245.1|3889431_3890058_+|TetR/AcrR-family-transcriptional-regulator
MSGAGARRVYGGVTGEERTAERRRKLIEAGMNLFGSASSGSVRVKDVVAEAGLTERYFYESFADLNALFGAVLGTAADEIESRVDAAMVDAPVDAFARVSIALRTTVEVLAGDRRMIRIFFVEGLGSSGRGGVHRNEILARSAGNFSKWSAPGAPSFDGSTSDARMKALAMSGAASELLISWADGLLEVTPAELADFLVGLYWRMNLP
>NZ_AP022616.1|WP_163693182.1|3888657_3889275_-|DUF1345-domain-containing-protein
MSGTDRFWISSAIGVVSGGAAWLLLDRWPVGLLVVVIATAATHVAWTLAVHWPMDPEQTREHARNEDVNNDVGNLVRLLILAGSLSAIGILLKSADDADKASYAGLSLAAILSTWALLHTMHTARYARFYYSGEPGGIDFNSTVPPRYVDFYYFSFNLGMTYQVSDTAVTESDIRAEVLEHCLFSYIYGTVIIACTINLVINLVG
>NZ_AP022616.1|WP_138251247.1|3888005_3888674_+|DinB-family-protein
MNGSTAVDVVVGPFPSLDECVEAIPTRSGYRSESPHRGECQTGPVTTPDPIEPDTKDWTWVLSRACPDCGFDASAVRPADVADRIRDDAADWVHRLASADVRTRPRPGVWSTLEYGCHIRDVHRIFEHRVQLMLTEDDPRFPNWDQDETAIADDYPSQDPAVVATELFDAANIVAATYANVPADAWDRRGLRSNGSEFTIATISLYHLHDIVHHAYDVSPRG
>NZ_AP022616.1|WP_167526472.1|3887197_3888007_-|SMP-30/gluconolactonase/LRE-family-protein
MDGFVYGEGPRWHDGRLWFSDGPAGRVYSVGETGDLTVAAEVPRASGLGWLADGTLVVSTLFEATIQHVDGQGNTTATFDLSGLAWSTNDLVVTPDGRGYVDLYKQTNNALVGEIGLVDPTGTVRIVATGLAVPNGLGFLPDGSTLVVSETNGSRLLAFSTEPDGSLGAPTVFADLGPGRHPDGLCIDAEGGVWVGCYDSGEFLRVVAGGTVTDRITIDGGWAVAPALGGADGRTLYLVVDDTTHEGLMRGESAGRIMQTRVDVPAAPT
>NZ_AP022616.1|WP_138251275.1|3885766_3887083_-|amino-acid-permease
MHRELKNRHLQMISLGSAIGTGLFLISGTSVQAAGPIVLVGYAIAGIVLYGVMRMLGEMAVAHPVAGSWSAYAREYLGKPAGFIAGWNWWYVCVVVCMVELTAASEFMAFWFPDMPHWITTAVCLVLITGANMINVKAFGEFEFYFTLIKVTAVIAMIVLGIAIIFGAGDYNVHGLQNLWAHGGFAPKGLGAFMISLVAITFSFGGIESLGTAAGEVEEPARNIPRAINQVLLRILVFYVGAIGVMLIIWPWDQVGTEGSPFVLMLVGLGIGGAATLLNVVVLTAALSVANVMTYSNARVLYDLAASGQAPRFLAHTNAQGVPVRALLLNSGFVAVAVLLNVLLPGKALVVLIPVVVGAELITWSIIALSHLRFRAREGAGVFKTPLSPITNYLCLGYFALIYILMTQDPASHAGAIALPLWFCGLLIVGFVLGRVRR
>NZ_AP022616.1|WP_138251276.1|3884253_3885612_-|serine-hydrolase
MPTVVPAGPFAAVSRLVNDAIAAHRLPGAVIQVGHAGKVVFRQAYGARRLGDEPALDGSSSPAEPMTDDTIFDLASLSKSIATTVAVLQLYEKGLVQVDEPVQTYFPEFNATNDPRRAQVTVRMMLTHTSGTGGDLSHQGPWGLTSADKAEGIRRALTAPLEFGPGEGFHYSDLNFIILGALIEKITGESLDNYVQDNVFAPLGLADTRYLPATKACGPHQVRGTAIVFEGVPSEPCPPGTWSTALLARVAPTAHDDDTPGINPDFDHLIRGTVHDPTARRMGGTGGSAGVFSTADDLGRYAQALLDRLAGRPSPFPLQQSTAELMATPQQPGHNAGQVPAAARASRYAAENHPNTTDPLLAPNYPAIAGQELRSFGWDIDTEHSRPRGMVFPVGSFGHTGFTGVTLWIDPGSDTYVVVLANVIHQRGGPPIARLSGDIATEAGRALRLYGN
>NZ_AP022616.1|WP_138251249.1|3883851_3884274_+|hypothetical-protein
MQHVQETNLAWSLIDVAKPELDARERNHVFISVGAGDSFTSIRILLKLIAVKRIPVKAELVQLCDTWLEAYVLHEDHERLRQVIDDLVVLAPNRRPVISRSLICVKSHAIYVDCESTHSATRPFATSVRSQRRPSVSVQS
>NZ_AP022616.1|WP_138251250.1|3883655_3883844_+|hypothetical-protein
MDINESNSPARQFNIGDLVRNGPHVGTVTDVGSVLVAITTVMGTPRMVCPWELVQLRLAAPQ
>NZ_AP022616.1|WP_138251241.1|3893585_3894953_+|NAD(P)-binding-protein
MAADVDFCVVGAGFAGLTAAVRLKQSGHSVALLEARDRVGGRTYTEVLPDGTWIDRGGAWVGPGQDRIKALMAEYGVGEYKEYVDGDAMMVIDGKTHRYSGTIPWAMSPWAIANLGAGLLEVGQMCKTIPFDAPWEAKKAAEWDRITLGEWLNRNIHSHQAREMLDMAMAGIYTSAASEVSLLWALHQMGSGGGPVFVISNSGGAQDARVRGGMGAVYGPMAAELGDALHLSRPVDLIAQDDDGVTVHSKRLTVRARHVIVAVPLAIATHIEYEPMLPVDRAFLHRRMPSGAVYKISVVYDTAFWRSDGLCGQSAAPGSPATLTIDACTDTGTPGIMCVITEGPAARKLGLLDPAARKAAVIGELVDRFGAKAASPVSYHEQDWTTERYSGGGMISHAPPGVLTEFGHALRTPCGRIHWAGTESSAIMCGWIDGAVRSGERAAAEVMAAESVLAG
>NZ_AP022616.1|WP_138251274.1|3894956_3896321_-|AarF/ABC1/UbiB-kinase-family-protein
MARRLPEGRLARGGKLGALAAKQAVRGGRTRLSMVGRSERAKELLAERATIEMAENLVTVLGSMKGAAMKLGQMLSVIELDLVPESHREQFREKLAALRDQAPQAPFSAMRDVVESDLGPMSSVFADFDESPTAAASIGQVYRARLRDGRDVAVKVQYPGVDRAIQADMRNLALLMKLWRLWPSANTAMLDEITRNFESELDYLREADTQHVVAEQYRGHPFIVVPDSVREYCTPRVLVTEYLEATGFEHMRTLPAADRNHIGELVYRFYIGSLFTNHEFCGDPHPGNIMLAADGRVGFVDFGLYNRMDPANVAFELDCFHAAIDGRADDLYRLMLGRGIVDTESGVTAQDCLEYIWAASEWHMIDEDLTITSELATGAVVSAIDPRQTEFAGMKRQMVPPEHVFSRRADFLTFGTLGHLQSTNNWYRIGQEWFFGRPPATEVGREIARWRSSR
>NZ_AP022616.1|WP_163692878.1|3896374_3897271_-|hypothetical-protein
MADILTRAQLSLLADLLQTDTARLSSLERLGADDLKALRGALSDALFDEQAEAFARVGRLAPLVPNALVVTVAQRAVPPEVAGRVGGAVGLAHSDRAIGVLSGLKPTYLADAAPYVDPRVIPHFAPRLPAKLLIPAAKELLRRRDYLTASRFVEFATEEHIVAFEKAIDDDEGIILTGVLVSDTAIMNDIMRAAGPDRALRMARTAAQGNSDVLAALLSLLNRIDPELARPAVAELLGHPDAERVTYVLDVAVSEGVVLETLEVSAALDGDALTRLTSLEAWHRLIGAADSWANETPA
>NZ_AP022616.1|WP_138251238.1|3897278_3897500_-|hypothetical-protein
MAAAGTDNPLLDELKEPRDVLEKLTPEESALLLGLLRKARVAHQHGLDRSLDDGLKVLPRLIRPAARKILFGK
>NZ_AP022616.1|WP_138251237.1|3897620_3898271_+|TetR/AcrR-family-transcriptional-regulator
MEDAEDVVAARKVLTRAESQAQTRQELLDAAERLFYANGYHSTSLAAIAAEAGRTIGAVYSNFEGKEALCLEVIRNRYMAELNQLLGPLMAAGESADDRLAALASWWARIGAEPNLVVLTAEYATSTFHDPVQLAKAREAIERFKESTRVILEDAVPEGVPPDHPLMDDAIEVAVATGSGIAMAQAVGTIDAERGAALMVANLKLWFDTLANGRPD
>NZ_AP022616.1|WP_138251236.1|3898267_3898825_-|hypothetical-protein
MSRVDVISNERVFDDRHHLHEFQDFWRDGPVALVFLPQFGSAFGLAQARALTSRFDEVEALGAQVILIGIGTSIQGFTFRNRARSRFPVMATQDHTLYRTMGLASRHRLFDPIRNAKAFITAVQAGVYPYQRTGDPSRLGGVFVVEQGGRQVIWDHRARCAADLASADDVVAALRTAATRQVTTS
>NZ_AP022616.1|WP_138251235.1|3898821_3899928_-|DUF2236-domain-containing-protein
MKSVRLQDVAMPKAERQRIDRRYDFLLKLHGKNGKKALAIAEAPRIDNGYFGPESISWKVYENVMVAGMGALSGLFISVLDPDGAYGVGHHTTYYYDTIGRIRRSLHFFAGAVAGDTANAEKVGVDLFRKHSHITGEVPATGELFQANHVETLKFTYVVGWPHLWRAYKAFGDPHATDDDERQFYREQVKVCQLMGMPAGELPDTPENVEAWVQRAEQELMAFTRPAQELTDFMTHPPMTPLYPNLVIGVLMRVAIWAAIPLLTPYVRQICGLEDYRMRPRLGALLVKATVKALQNPIFDRIFIPYFGPETWGYLHNVIRHADSTGFVEMTHDPGLTLQHGKRGTMCPFAPAAPDAAEPSNTVVGVGR
>NZ_AP022616.1|WP_138251273.1|3900127_3900553_+|nuclear-transport-factor-2-family-protein
MVDAEELRAGLGAFARMVDGKRWSDASQVFADDVTFDYGDQGPQSGLPALVETFRRYLEKCGGTQHLIGSIQVEVRDDDTAVTRAYVQARHQGLGPLAADTFDTNGEYTDTWARRPEGWRIVNRISRWSAMSGNPAVLFPQ
>NZ_AP022616.1|WP_053854963.1|3900558_3901581_-|dehydratase
MTTAAEASPLEARIGHHYQMDGTYLVGREKLREYARAVQDYHPAHWDVAAANELGYADVIAPITFTSTPGMKCNRRMFESIVVGYDTYLQTEEVFEQHRPIVAGDELVIDVELTSVRRTAGRDFITVTNTFTDTKGERVHTLHTTVVGVTAEDIDGDVKTAVQKAMMHDMNILDIGSEEYRKTVRPEGEVRIATDAARTPGTPSFDDVSVGDELPASHLRLSLGDLVNYAGVAGDANPIHWDKDLAQLAGLPDVIAHGMLTMGLGAGYASTWSGDPGAVSRYTVRLSAPAVVPATEGCDIEFSGKIKSLDPETRTGVVIVGAKSGGKKIFGLATMDVRFR
>NZ_AP022616.1|WP_064858884.1|3901763_3902651_+|hypothetical-protein
MARTPTLARRLFERYEPVHAITYFAPEARAAAVDLGYRSFWSGYFVTRSAPLGPVPPQVVEAIFYNFAAHRVAKSLAGAWDIATPQQALAAREAGAVAALRRYGLTADDTLRPAADLLGRVARGAAVDGRPLFAALSAAPWPDEPVAALWHAATLLREQRGDAHVAALVAAGITGRESNVLHVAAGRTTRDKVVSTRDYDDAEWDAVTARLAARGLVTADGSLTDAGRELKNDIEYRTDAAALATLDVLSDAEVEMLFQALTPIARMVVAGGDLPAITPMALQHSDLDDPSAHLG

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Crispr_ID: NZ_AP022616_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022616_5

4562314-4562417

Orphan

Consensus_repeat	Method
CAGATGGGCCAGCAGGCGGGCCA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_AP022616_5

>merge|NZ_AP022616|5|4562314-4562417|CRISPRCasFinder
CAAATGGGTCAGATGCTCGGCCAGCTCGGTCAGATGGGCCAGCAGGCGGGCCAAATGGCGGGCCAGGGTGGCGGCCTGGGCCAGATGGGCCAGCAGGCCGGCCA

>NZ_AP022616|5|5|4562314-4562417|CRISPRCasFinder
CAAATGGGTCAGATGCTCGGCCA	GCTCGGTCAGATGGGCCAG
CAGGCGGGCCAAATGGCGGGCCA	GGGTGGCGGCCTGGGC
CAGATGGGCCAGCAGGCCGGCCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022616.1\|WP_138250822.1\|4559037_4560828_+\|DUF2339-domain-containing-protein	unknown	unknown	gnl\|CDD\|378390
NZ_AP022616.1\|WP_163692949.1\|4562902_4564051_-\|DUF1942-domain-containing-protein	unknown	unknown	gnl\|CDD\|370335
NZ_AP022616.1\|WP_133426432.1\|4556402_4557368_+\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|224462
NZ_AP022616.1\|WP_061006707.1\|4551101_4551596_-\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|281995
NZ_AP022616.1\|WP_138250806.1\|4572142_4572913_+\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|187600
NZ_AP022616.1\|WP_138250809.1\|4568599_4569664_+\|4-hydroxy-2-oxovalerate-aldolase	unknown	unknown	gnl\|CDD\|181282
NZ_AP022616.1\|WP_061010174.1\|4551618_4552770_-\|steroid-3-ketoacyl-CoA-thiolase	unknown	unknown	gnl\|CDD\|181145
NZ_AP022616.1\|WP_138250840.1\|4560920_4562045_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237537
NZ_AP022616.1\|WP_138250812.1\|4565129_4566812_-\|3-oxosteroid-1-dehydrogenase	unknown	unknown	gnl\|CDD\|236111
NZ_AP022616.1\|WP_138250813.1\|4564267_4565128_-\|MaoC-family-dehydratase	unknown	unknown	gnl\|CDD\|178455
NZ_AP022616.1\|WP_138250811.1\|4566883_4567669_+\|2-keto-4-pentenoate-hydratase	unknown	unknown	gnl\|CDD\|226480
NZ_AP022616.1\|WP_138250807.1\|4571342_4572140_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223377
NZ_AP022616.1\|WP_138250808.1\|4569756_4571166_-\|wax-ester/triacylglycerol-synthase-family-O-acyltransferase	unknown	unknown	gnl\|CDD\|274360
NZ_AP022616.1\|WP_138250823.1\|4557768_4558929_+\|lipid-transfer-protein	unknown	unknown	gnl\|CDD\|181147
NZ_AP022616.1\|WP_138250824.1\|4557349_4557772_+\|MaoC-family-dehydratase	unknown	unknown	gnl\|CDD\|239539
NZ_AP022616.1\|WP_138250810.1\|4567697_4568603_+\|acetaldehyde-dehydrogenase-(acetylating)	unknown	unknown	gnl\|CDD\|236227
NZ_AP022616.1\|WP_138250805.1\|4572950_4573952_+\|permease	unknown	unknown	gnl\|CDD\|223773
NZ_AP022616.1\|WP_061006575.1\|4552927_4554175_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_AP022616.1\|WP_061010177.1\|4554223_4555228_+\|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NZ_AP022616.1\|WP_133426431.1\|4555227_4556391_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173841

Protein	Function_ID	Function_description	E-value
NZ_AP022616.1\|WP_138250822.1\|4559037_4560828_+\|DUF2339-domain-containing-protein	gnl\|CDD\|378390	pfam10101, DUF2339, Predicted membrane protein (DUF2339). This domain, found in various hypothetical bacterial proteins, has no known function.	1.20709e-11
NZ_AP022616.1\|WP_163692949.1\|4562902_4564051_-\|DUF1942-domain-containing-protein	gnl\|CDD\|370335	pfam09167, DUF1942, Domain of unknown function (DUF1942). Members of this family of bacterial proteins assume a beta-sandwich structure consisting of two antiparallel beta-sheets similar to an immunoglobulin-like fold, with an additional small, antiparallel beta-sheet. The longer-stranded beta-sheet is made up of four antiparallel beta-strands. The shorter-stranded beta-sheet consists of five beta-strands, four of these beta-strands form an antiparallel beta-sheet. The exact function of this family of proteins is unknown, though a putative role includes involvement in host-bacterial interactions involved in endocytosis or phagocytosis, possibly during bacterial internalisation.	7.26249e-35
NZ_AP022616.1\|WP_133426432.1\|4556402_4557368_+\|DNA-binding-protein	gnl\|CDD\|224462	COG1545, COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only].	4.36262e-24
NZ_AP022616.1\|WP_061006707.1\|4551101_4551596_-\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	gnl\|CDD\|281995	pfam04075, F420H2_quin_red, F420H(2)-dependent quinone reductase. This family of proteins is found in the genera Mycobacterium and Streptomyces. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. Rv1558 is an F420H(2)-dependent quinone reductase involved in oxidative stress protection.	1.27693e-41
NZ_AP022616.1\|WP_138250806.1\|4572142_4572913_+\|glucose-1-dehydrogenase	gnl\|CDD\|187600	cd05341, 3beta-17beta-HSD_like_SDR_c, 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs. This subgroup includes members identified as 3beta17beta hydroxysteroid dehydrogenase, 20beta hydroxysteroid dehydrogenase, and R-alcohol dehydrogenase. These proteins exhibit the canonical active site tetrad and glycine rich NAD(P)-binding motif of the classical SDRs. 17beta-dehydrogenases are a group of isozymes that catalyze activation and inactivation of estrogen and androgens, and include members of the SDR family. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	2.34877e-96
NZ_AP022616.1\|WP_138250809.1\|4568599_4569664_+\|4-hydroxy-2-oxovalerate-aldolase	gnl\|CDD\|181282	PRK08195, PRK08195, 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated.	0
NZ_AP022616.1\|WP_061010174.1\|4551618_4552770_-\|steroid-3-ketoacyl-CoA-thiolase	gnl\|CDD\|181145	PRK07850, PRK07850, steroid 3-ketoacyl-CoA thiolase.	0
NZ_AP022616.1\|WP_138250840.1\|4560920_4562045_+\|hypothetical-protein	gnl\|CDD\|237537	PRK13875, PRK13875, conjugal transfer protein TrbL; Provisional.	0.000132747
NZ_AP022616.1\|WP_138250812.1\|4565129_4566812_-\|3-oxosteroid-1-dehydrogenase	gnl\|CDD\|236111	PRK07843, PRK07843, 3-oxosteroid 1-dehydrogenase.	0
NZ_AP022616.1\|WP_138250813.1\|4564267_4565128_-\|MaoC-family-dehydratase	gnl\|CDD\|178455	PLN02864, PLN02864, enoyl-CoA hydratase.	1.88066e-61
NZ_AP022616.1\|WP_138250811.1\|4566883_4567669_+\|2-keto-4-pentenoate-hydratase	gnl\|CDD\|226480	COG3971, COG3971, 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism].	2.13793e-102
NZ_AP022616.1\|WP_138250807.1\|4571342_4572140_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|223377	COG0300, DltE, Short-chain dehydrogenases of various substrate specificities [General function prediction only].	2.00791e-63
NZ_AP022616.1\|WP_138250808.1\|4569756_4571166_-\|wax-ester/triacylglycerol-synthase-family-O-acyltransferase	gnl\|CDD\|274360	TIGR02946, Putative_diacyglycerol_O-acyltransferase_Mb3115, acyltransferase, WS/DGAT/MGAT. This bacteria-specific protein family includes a characterized, homodimeric, broad specificity acyltransferase from Acinetobacter sp. strain ADP1, active as wax ester synthase, as acyl coenzyme A:diacylglycerol acyltransferase, and as acyl-CoA:monoacylglycerol acyltransferase. [Unknown function, Enzymes of unknown specificity].	1.19797e-102
NZ_AP022616.1\|WP_138250823.1\|4557768_4558929_+\|lipid-transfer-protein	gnl\|CDD\|181147	PRK07855, PRK07855, lipid-transfer protein; Provisional.	0
NZ_AP022616.1\|WP_138250824.1\|4557349_4557772_+\|MaoC-family-dehydratase	gnl\|CDD\|239539	cd03455, SAV4209, SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and gamma-proteobacterial members of this CD have, in addition to a hot dog fold, an N-terminal extension.	3.37248e-50
NZ_AP022616.1\|WP_138250810.1\|4567697_4568603_+\|acetaldehyde-dehydrogenase-(acetylating)	gnl\|CDD\|236227	PRK08300, PRK08300, acetaldehyde dehydrogenase; Validated.	0
NZ_AP022616.1\|WP_138250805.1\|4572950_4573952_+\|permease	gnl\|CDD\|223773	COG0701, COG0701, Predicted permeases [General function prediction only].	2.90793e-36
NZ_AP022616.1\|WP_061006575.1\|4552927_4554175_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	3.95086e-93
NZ_AP022616.1\|WP_061010177.1\|4554223_4555228_+\|acyl-CoA/acyl-ACP-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	1.00674e-33
NZ_AP022616.1\|WP_133426431.1\|4555227_4556391_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	2.06295e-114

>NZ_AP022616.1|WP_138250840.1|4560920_4562045_+|hypothetical-protein
MGIQPDSSPFGSQTVTGPGWPNVNEEQLEEAAAHYTKLATKISGSVVPQQTSQLMNLTDQWQGAASLAAAGEAGTIIGGHEANGAQAAAIAAKLQSMAAAVVKTKNLVNATAEEVQAECMALSAAPFPNVQELIQSRIKMGLSQNIAAVTASATEVANFVGAPPSIPTAGVPPQVAQTAQKTAESAGKGGDQMGQMMGQMMQMAGQLPQMLGQLPQQAMQPLQQLSQPLQQLTSLFSGGGQGKAGLGASPFGAFSNHPLAGGSGAAHGAGLMKGGMPGGGGGGVGAASVQTPLLAKMVGPGPAGPGVMPASAAAGMGAGGLAPVAAAAGAGGAMGAMGGMGHREGGGGGGRITQLAVPEALEHGSYDEDIDDDW
>NZ_AP022616.1|WP_138250822.1|4559037_4560828_+|DUF2339-domain-containing-protein
MTEPQRAMVARLSQDVAAISHHLAWVSACLTELDRSMAYQQPAAQPVTYAAPQQYWQPSRTAPVAGPTPPPMPQPTPQPAPQPRPERSDGWIGKALAAAGVAVTLIGVALLLVLAAQAGLLRPEFRVGAGAVLAAGLVFGATRLKTRPGGTVGAVALAATGIAAAYIDVVAVTTIYEWLSAPVGLVLAAVIGGGGLTLARRWDSQQLALLVLVPLAVLAPVVADGVSLLLIGFMLALSAASLPVQFGKDWVAMFVARTAACTFPMLVALASAAFGTDRNPGLAGACAAAAVLAVGGAVLLLPTTSNRSLLGLATAGGALPVLFVSAVVGPLIAASIIAAVAALFLAVVLAGSRLPGVAGVVRRIWSAVAAVCALVAVLVAFGGRTGGAVLLAMSVVVAVAGRRDAIARWVAAGFGAVGGAVYLSYSPPDLLFRAVELTAHSAVSTVIASILAVASAVAVVWSWTGRRDDDELRLMWAGAVVVAAYASTMSTVTAGVLIGGVKGGFLAGHMVATIGWIAVAAALFAYAARQPRAQRSLPIGGGLTLVAAAMAKLFLFDLGTLSGMFRVAVFIVVGLVLLAMGTGYARLLARQDQPNP
>NZ_AP022616.1|WP_138250823.1|4557768_4558929_+|lipid-transfer-protein
MSISGKAVIAGIGATDFSKNSGRSELRLAAEAVTDALNDAGLSPKDVDGLVTFTMDSNLETAVARSTGIGELTFFSQIGYGGGAAAATVQQAVLAVASGIAEVVVAYRAFNERSEHRFGQVMTGLTVNADSRGVEYSWSYPHGLSTPAASVAMVAQRYMHEYGATSADFGVVSVADRKHAATNPKAHFYGKPITIEDHQNSRWIAEPLRLLDCCQETDGGVAIVVTTPERAKDLKQRPVVVEAAAQAAGEDQFTMYSYYRDELGLPEMGLVGKQLWGQSGLTPNDIQTAILYDHFTPYTLIQLEELGFCGRGEAKDFIANGAIELGGKLPINTHGGQLGEAYIHGMNGIAEGVRQLRGTSVNQVPDVEHVLVTAGTGVPTSGLILG
>NZ_AP022616.1|WP_138250824.1|4557349_4557772_+|MaoC-family-dehydratase
MGGSEVTATVSATVGTKLPELSIYGDPTFIVSTAIATRDYQDVHHDRDKAQAKGSKDIFVNILTDTGLVGRYVTDWAGPNAIVKSIKLRLGVPWYAYDTITFRGEVTAVEGDLVTLKVVGTNSLGDHVIATSTLTMGAAQ
>NZ_AP022616.1|WP_133426432.1|4556402_4557368_+|DNA-binding-protein
MTDLQAGIDEIVASGRSKPTLSRDPVNQPMIHHWTDAIGDKNPIYVDEEAAKAAGHPGIVAPPAMIQVWTMMGLGRTRSDDDPLARIMKLFDEAGYVGVVATNCDQTYHRYLQPGERVSISAEVTDVVGPKQTALGEGYFVNQKIRWHVGDEEVADMDWRIMKFLPANKQGKEAAETGSIPADLDPDKLMRPSSSRDTQFFWDGVNAHELRIQKRPDGSLQHPPVPAIWQDKDAPIDYVISSGRGTVFSYVVHHAPKVPGRSLPFIIALVELEEGVRMLGELRGVEHDDVKIGMPVSATFLDFPDSDVSPAWSLYAWEAAK
>NZ_AP022616.1|WP_133426431.1|4555227_4556391_+|acyl-CoA-dehydrogenase
MFIDLTAEQRKLQSELREYFSTLITPEEAAAMETDRHNEAYRTVIKRMGSDGKLGVGWPKEYGGLGFGPIEQQIFINEANRADIPLPMVTLQTVGPTLQLLGTEEQKKKFLPGILAGEVHFAIGYSEPEAGTDLASLRTTAVRHGDEYIVNGQKMWTTGAHDADYVWLACRTDPTAAKHKGISILIVDTKDPGYSWTPIILSDGAHHTNTTYYNDVRVPADMLVGEENGGWKLITTQLNHERVGLGPAGRVAGIYEQVHAWASEAGSDGVVPLDNPEAKRLLGQIKSIMRLNELLNWQVASSGENIAVADAAATKVFSTERIQEVSRLAEEVVGRFGNPADKHTATVLQWLDTMAKRNLVITFGGGVNEVMREMIAASGLKVPRVSR
>NZ_AP022616.1|WP_061010177.1|4554223_4555228_+|acyl-CoA/acyl-ACP-dehydrogenase
MDFTPSPEQQAVADVVTSVLERENTWDALVSGGVVALAVPDRLGGDGLGLPEAATALTEIGRRGTTGPALATIGLALVPLVDLATEAQQDRYLAGVASGAVLSAALNEAGNQLPEKPSTSYAGGKLNGTKIGVPYAETAQWLLVTTDSGVVVVSPTAAGVTVEKTPTANGSDEYVVTFTDVAVADDEVLAGATVARVNELALAMIGAFGAGLVAGALRLTADYTATREQFGRPLSTFQTVAAQLSEVYIASRTIDLVSTSVVWRLSEGLDAAEDLAILGYWLTSQAPPAMRLCHHLHGGMGMDITYPMDRYYSSIKDLNRLLGGPSHRLDLVGA
>NZ_AP022616.1|WP_061006575.1|4552927_4554175_+|cytochrome-P450
MPCPIPSDFDLLDANLNLQGLPIEELAALRKSEPVHWVDVPGGTGGFGDKGYWIVTRYEDVKEVSKRNDIFGSAPDGAIPVWPQAMTREAVDVQRAVLLNMDAPQHTRLRKIISRGFTPRAIGRLQAELNERAQKIAETAAASGTGDFVEQVSCELPLQAIAGLLGVPQEDRDKLFNWSNEMTAGEDPEYAHIDPAASSFELITYAMGMAAERSKNPTEDIVTQLVQADIEGEKLSDDEFGFFVVMLAVAGNETTRNSITHGMIAFAQNPDQWELYKKERPESAADEIVRWATPVSAFQRTALEDTELGGVKIKKGERVVMSYRSANFDDEVFEDPHTFNIMRTPNQHVGFGGTGAHYCIGANLARMTINLMFNAIADHMPDLASIGEPERLMSGWLNGIKHWQVDYTGKCPVQH
>NZ_AP022616.1|WP_061010174.1|4551618_4552770_-|steroid-3-ketoacyl-CoA-thiolase
MGNPVIVEATRSPIGKRGGWLSGLHATELLGATQKALVEKAGLDAGDIEQLIGGCVTQYGEQGNNITRQSWLVAGLPEHVGATTIDCQCGSAQQANHLIAGLIATGAIDIGIACGIEAMSRVPLGANGGGARAASWDIDLPNQFEAAERIANRRGITRADIDALGFASQAKAKQAWAEGRFDREISPIEAPVIDENKQPTAELNWVTRDQGLRDTTLEGLAALKPVIEGGIHTAGTSSQISDGAAAVLWMDEDKAKALGFTPRARIIAQANVGAETYYHLDGPVQSTAKVLEKARMSMADIDLVEINEAFASVVLSWAQVHKADMDKVNVNGGAIALGHPVGSTGSRLITTALHELERTGKSTALITMCAGGALSTGTIIERI
>NZ_AP022616.1|WP_061006707.1|4551101_4551596_-|nitroreductase-family-deazaflavin-dependent-oxidoreductase
MADGEMSDRQLKILNSKGMQVGFKWMSRINTWAFRATDGRIGAKWRLGSKPVATPPPVGILTTIGRKSGEPRDSPLLYLREGDRIVVVASQGGRDTHPMWYLNLVANPKVKFQVRGEKLQLLAREATDAERDEYWPKLDAMYPDFVDYRSHTDRKIPIILLDPA
>NZ_AP022616.1|WP_163692949.1|4562902_4564051_-|DUF1942-domain-containing-protein
MSTRKITIAIGAAAAFGLIATPFAVADSTQPASVSPAPTTIAFGKDGKLVDGNTVAEWQISNLKPSTDVLSQHLNGTLWEATAEYSAERGSSQPFVPNLNARTADGENYRVLWGAATPQGLNPAGLSEGQESKGKVYFDVTGAAPTSVVYTDGDREVLKWQGTEAATGAAPAAAPARGTAPAATPAPAAAPAAAPAAAPAAAPAGLGSAVPGATPAGSVPAAAGTQPPAGTTTGQVPAATPNGETPAATPAGTPAPAGTPAVAPAPAGTPAADAPAPAGAQVPAGTPAGTPAGTPATPPAAGQVPEAAPVPTAAESGPGTAATAGGAVSQAPLTPAPAPAPSQAIAGQPASSAGQGTTAPAGNQQAAPAAPVTPTPAPAPAS
>NZ_AP022616.1|WP_138250813.1|4564267_4565128_-|MaoC-family-dehydratase
MPINLDEAIGAELAPVEFSWSSSDVQLYHLGLGAGADPMSERELRYLIDDKPQVLPTFGNVAQSFHETKAPSVKFPGIDIELSRVLHASEAIYTDAPIPPSGTGRAVTRFTEIWDKGKAAVIWSETTVTTLDGAPLWKQKRSIFARGEGGFGGDRGPSTSAAEPDRAPDLQIALPTLPQQALLYRLCGDRNPLHSDPAFAKAAGFDRPILHGLCTYGIGCKAIVDNVLDGDAGRVRSYGARFAGTVIPGETLQANLWRDGERITGVLTAPSRDNVVVLAGIELTAS
>NZ_AP022616.1|WP_138250812.1|4565129_4566812_-|3-oxosteroid-1-dehydrogenase
MTGQEYDVVVVGSGAAGMVAALTAAHQGLSTVVVEKAPHYGGSTARSGGGVWIPNNEILQRAGVKDTPEAARTYLHKIVGDVVPAEKIDTYLQRGPEMLSFVLKNSPLKLCWVPNYSDYYPEVEGGRAGGRSVEPKPFNAKKLGADEKGLEPAYGKVPLNMVVMQQDYVRLNQLKRHPRGVLRSLKVGIRATWAGATGKNLVGMGRALIAPLRIGLQKAGVPVQLNTALTDLYYENGRVAGIYVRDTNAPESAEPQLIRARRAVILGSGGFEKNQEMRTKYQRQPITTDWTVGAKANTGDGILAAEKLGAALEIMEDAWWGPTVPLPDNPWFALSERNSPGSIIVNMNGKRFMNESMPYVEACHHMYGGQYGQGEGPGENVPAWLLFDQQYRNRYIFAGLQPGQRIPKKWTEAGVVVKADTIEELAALTNLPVEELKATIERFNGFARSGVDEDFGRGNSAYDRYYGDPTNKPNPNLGEIKHGPFYAAKMVPGDLGTKGGIVTDIHGRALREDGSVIEGLYASGNVSGPVMGHTYPGPGGTIGPAMTFGYLAALHVAGKG
>NZ_AP022616.1|WP_138250811.1|4566883_4567669_+|2-keto-4-pentenoate-hydratase
MLSDNVRAELAAALAQAERSRVAMTPMTDDHADIDVIDAYEIQLLNIRQRVAEGARVVGHKVGLSSEAMQKMMNVDEPDYGHLLDDMQVFEDKPVLTSNYLSPRVEVEVGFVLADDLPGAGCTEDDVLAATAAFAPAIELIDTRITNWQIKLCDTIADNASSAGWVLGKERVSPKDIDIRNIDAVLKCNGEVLGEGRSDAVLGNPVTAVAWLARKVDQFGVRLKAGDVVLPGACMRAFDAKPGDDFVAEFAGLGSVHLSFA
>NZ_AP022616.1|WP_138250810.1|4567697_4568603_+|acetaldehyde-dehydrogenase-(acetylating)
MPSKASVAIVGSGNISTDLLYKLLRSDWLEPRWMIGIDPESEGLARARKLGLETSAEGADWLLAQSEKPDFIFEATSAYVHKAYAPRYEEAGIRAIDLTPAAVGPGVIPPANLRAHLDSMNVNMVTCGGQATIPMVYAVSRVVDVPYAEIVASVSSASAGPGTRANIDEFTKTTSAGVRDIGGARDGKAIIILNPADPPMIMRDTIFCAIPEDADHAAITQSIKDVAAEVQTYVPGYRLLNEPQFDEPSMVNGGQHVVSIFVEVEGAGDYLPPYAGNLDIMTAAATKVGEEIAKQIVEVKA
>NZ_AP022616.1|WP_138250809.1|4568599_4569664_+|4-hydroxy-2-oxovalerate-aldolase
MSTALEPGDIFFDAAWDVRMTDTSLRDGSHHKRHQFTGNEVRAIVGALDNAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKIAAETAKTAKIAFLMLPGVGTKEDIKEAQGNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMSHTISPEKLAAQARIMADAGCQCIYVVDSAGALVLEGVADRVGALVAELGNDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGNAPVEALVGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALVMGYAGVYSSFLKHAVRQGERYGVPAHELLLRVGQRKLIGGQEDQLIDIALEIQRERAEGKS
>NZ_AP022616.1|WP_138250808.1|4569756_4571166_-|wax-ester/triacylglycerol-synthase-family-O-acyltransferase
MRRLSGEDNSFLAWESAVQPQHTIKAVVLDPAQGHEPVTFEAVRAALPGLVDRVEPMQWQLMSPRFGAGRPWWITRARGDLNYHMKRATAAAPGTDRELGAEIAKLFEEPLDRNRPAWQLWYIDGLANGRVALVLKIHHAVADGMASLNLLEQFYSQDPADRLPEPSARPVPDEHRPPTAEWLPMVARQQVTSLTKFPKVLARTAKVTRTIQNRQKAGKPGYAEAFIPPALPFNEPLTARRGFAFVGVEMDQIKRVSKAFGVSVNDVFLAMCSTVLREYQASRGPVGDDTMTAVVPVSMRPQDGDRWGNKVARWNVELATNIADPVERLKTISANTATAREVQSERDAWLQHDWMEYWPLFKVYSRVLPTIGAQVKKRPMFSMIASNMRGPQQTLYFGGAPVEKLISTGPLVFPMGMNITGWSYEGGMQICVLTCTDQVSDPQAIADRLPAALAELVARCETAADPVTS
>NZ_AP022616.1|WP_138250807.1|4571342_4572140_+|SDR-family-NAD(P)-dependent-oxidoreductase
MQLRNSRVLVTGASRGLGRNIAQAMARRGADVALVARNAEQLEELAKELGGKAYPADLMDPAAVEELIGRVEADGPVDVIINNAGVDRVGRFYEASAADVRDLLQVNLIAPMELCRQVMPGMIARGRGHIVNVSSMGAISTGPGVTLYGASKAGLSHFTAGIRSELRNKPVGTTLVQIGEVKTDMIDHIRSFGPARRTIERSLKFRMIPQEPLDADMVAEAIADAVEKEKKHVILPKRIAAMAYLTETPRRVSELMLTGIDQDSD
>NZ_AP022616.1|WP_138250806.1|4572142_4572913_+|glucose-1-dehydrogenase
MDLIGKVAIITGAARGQGEAEARLFAERGAQVVLTDVLVDEGEAVAASIGTAARFQRHDVGSETDWRTTVELALSEFGRIDALVNNAAICTVEPLLDHTAESWERQLRVNLIGPFLGTKAVVEPMRAVGGGSIINVSSQAGLQGLAGYSAYGASKWGLRGFSKVAAIELGPMGIRVNTVYPGMIDTPMVAHLPIERGLGGHPGAPLTRVGAPGEVAEVVAFLASDASSYMTGADLAVDGGASAGRIPVVPTRPQAT
>NZ_AP022616.1|WP_138250805.1|4572950_4573952_+|permease
MAGDESTLAPVRRRRAGSMELLLIALTALALSGSWVSGVLTDHARLAAAATVFCGVFVQALPFLVLGVIVSGLVAAYLTPERLARRLPRRPALAVAVAGVGGAALPGCECGSVPVARRLFSGETAGAALTFMLSAPAINPVVLVATAVAFPGQPQMVVARCVASLATAVVMGLLWQRWGRTEWVTRTLPAHHDEGASRFTVFTEAARHDFLQSAAYLVVGAAAAAVLRAAVPPWVFEHVAGNLVVGVVTMALLAVVLALCSEADAFVAASLTMVPLVPRLVFLVVGPAVDVKLFAMQAGVFGRPFAVRFAPVTLVVATACATVVGLLVLEGAS

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Crispr_ID: NZ_AP022616_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022616_6

4687150-4687218

Orphan

Consensus_repeat	Method
GGCGGCACTGGTGGCACCGGTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022616_6

>merge|NZ_AP022616|6|4687150-4687218|CRISPRCasFinder
GGCGGCAAGGGCGGTAATGGCGGCGCAGGTGGCTTCGGTGCGACTGGCGTCACCGGCGGCGCGGGCGGT

>NZ_AP022616|6|6|4687150-4687218|CRISPRCasFinder
GGCGGCAAGGGCGGTAATGGCGG	CGCAGGTGGCTTCGGTGCGACT
GGCGTCACCGGCGGCGCGGGCGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022616.1\|WP_138250712.1\|4698967_4700590_-\|phosphomethylpyrimidine-synthase-ThiC	unknown	unknown	gnl\|CDD\|236451
NZ_AP022616.1\|WP_073694769.1\|4684621_4684849_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|366402
NZ_AP022616.1\|WP_061003619.1\|4678294_4678972_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_AP022616.1\|WP_138250719.1\|4680461_4680920_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236846
NZ_AP022616.1\|WP_064860949.1\|4682924_4683566_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022616.1\|WP_138250718.1\|4690288_4691761_+\|M28-family-peptidase	unknown	unknown	gnl\|CDD\|349873
NZ_AP022616.1\|WP_082761734.1\|4684218_4684644_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|379059
NZ_AP022616.1\|WP_162563420.1\|4693315_4693720_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226406
NZ_AP022616.1\|WP_138250715.1\|4695982_4697470_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224983
NZ_AP022616.1\|WP_138250714.1\|4697484_4698111_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|226101
NZ_AP022616.1\|WP_061002165.1\|4693793_4694426_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_AP022616.1\|WP_064860937.1\|4681117_4681597_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237976
NZ_AP022616.1\|WP_138250717.1\|4694422_4695628_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NZ_AP022616.1\|WP_165605570.1\|4678092_4678248_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022616.1\|WP_073694771.1\|4681621_4682854_-\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|235010
NZ_AP022616.1\|WP_133427884.1\|4678932_4680261_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_AP022616.1\|WP_138250716.1\|4695687_4695966_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226720
NZ_AP022616.1\|WP_061002140.1\|4691757_4693233_+\|M28-family-peptidase	unknown	unknown	gnl\|CDD\|349873
NZ_AP022616.1\|WP_163692956.1\|4685169_4685919_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_AP022616.1\|WP_138250713.1\|4698113_4698971_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|180561

Protein	Function_ID	Function_description	E-value
NZ_AP022616.1\|WP_138250712.1\|4698967_4700590_-\|phosphomethylpyrimidine-synthase-ThiC	gnl\|CDD\|236451	PRK09284, PRK09284, thiamine biosynthesis protein ThiC; Provisional.	0
NZ_AP022616.1\|WP_073694769.1\|4684621_4684849_+\|PAS-domain-containing-protein	gnl\|CDD\|366402	pfam00989, PAS, PAS fold. The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.	8.70585e-06
NZ_AP022616.1\|WP_061003619.1\|4678294_4678972_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.03559e-84
NZ_AP022616.1\|WP_138250718.1\|4690288_4691761_+\|M28-family-peptidase	gnl\|CDD\|349873	cd03876, M28_SGAP_like, M28 Zn-peptidase Streptomyces griseus aminopeptidase and similar proteins. Peptidase family M28; Streptomyces griseus Aminopeptidase (SGAP, Leucine aminopeptidase (LAP), aminopeptidase S, Mername-AA022 peptidase) subfamily. SGAP is a di-zinc exopeptidase with high preference towards large hydrophobic amino-terminal residues, with Leu being the most efficiently cleaved. It can accommodate all except Pro and Glu residues in the P1' position. It is a monomeric (30 kDa), calcium-activated and calcium-stabilized enzyme; its activation by calcium correlates with substrate specificity and it has thermal stability only in the presence of calcium. Although SGAP contains a calcium binding site, it is not conserved in many members of this subfamily. SGAP is present in the extracellular fluid of S. griseus cultures.	1.71093e-106
NZ_AP022616.1\|WP_082761734.1\|4684218_4684644_+\|PAS-domain-containing-protein	gnl\|CDD\|379059	pfam13188, PAS_8, PAS domain.	0.000140775
NZ_AP022616.1\|WP_162563420.1\|4693315_4693720_+\|hypothetical-protein	gnl\|CDD\|226406	COG3889, COG3889, Predicted solute binding protein [General function prediction only].	2.94253e-05
NZ_AP022616.1\|WP_138250715.1\|4695982_4697470_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224983	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism].	1.19064e-99
NZ_AP022616.1\|WP_138250714.1\|4697484_4698111_-\|alpha/beta-hydrolase	gnl\|CDD\|226101	COG3571, COG3571, Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only].	3.44444e-69
NZ_AP022616.1\|WP_061002165.1\|4693793_4694426_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	9.92145e-33
NZ_AP022616.1\|WP_064860937.1\|4681117_4681597_-\|hypothetical-protein	gnl\|CDD\|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	8.27643e-30
NZ_AP022616.1\|WP_138250717.1\|4694422_4695628_+\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.38484e-20
NZ_AP022616.1\|WP_138250719.1\|4680461_4680920_-\|hypothetical-protein	gnl\|CDD\|236846	PRK11100, PRK11100, sensory histidine kinase CreC; Provisional.	2.76328e-07
NZ_AP022616.1\|WP_073694771.1\|4681621_4682854_-\|ATP-grasp-domain-containing-protein	gnl\|CDD\|235010	PRK02186, PRK02186, argininosuccinate lyase; Provisional.	1.37025e-23
NZ_AP022616.1\|WP_133427884.1\|4678932_4680261_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.37059e-45
NZ_AP022616.1\|WP_138250716.1\|4695687_4695966_-\|hypothetical-protein	gnl\|CDD\|226720	COG4270, COG4270, Predicted membrane protein [Function unknown].	3.97323e-06
NZ_AP022616.1\|WP_061002140.1\|4691757_4693233_+\|M28-family-peptidase	gnl\|CDD\|349873	cd03876, M28_SGAP_like, M28 Zn-peptidase Streptomyces griseus aminopeptidase and similar proteins. Peptidase family M28; Streptomyces griseus Aminopeptidase (SGAP, Leucine aminopeptidase (LAP), aminopeptidase S, Mername-AA022 peptidase) subfamily. SGAP is a di-zinc exopeptidase with high preference towards large hydrophobic amino-terminal residues, with Leu being the most efficiently cleaved. It can accommodate all except Pro and Glu residues in the P1' position. It is a monomeric (30 kDa), calcium-activated and calcium-stabilized enzyme; its activation by calcium correlates with substrate specificity and it has thermal stability only in the presence of calcium. Although SGAP contains a calcium binding site, it is not conserved in many members of this subfamily. SGAP is present in the extracellular fluid of S. griseus cultures.	1.73225e-81
NZ_AP022616.1\|WP_163692956.1\|4685169_4685919_+\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	5.04101e-55
NZ_AP022616.1\|WP_138250713.1\|4698113_4698971_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl\|CDD\|180561	PRK06427, PRK06427, bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed.	5.66931e-140

>NZ_AP022616.1|WP_163692956.1|4685169_4685919_+|diguanylate-cyclase
MRTGQPVYAQVLGLRRDDGHQSWISFTTTLLNPDEPERSPIVMSLTDVTTEHLTNLHLRRAAHHDTLTGLPNRGRALAMITAAMTPSDHPHLAALMFIDIDQLKRINDSLGHHVGDVVLQACAERLQGAIRATDTLARVGGDEFVVLVAAPASAADLQQIARRLHHALENPIVTDEHTIAVSASIGVAGVDPTRPTTPTDLLRQADAAMYQAKATGSGETRFLSVHSATPRHRSDADPRHSSTPPERRL
>NZ_AP022616.1|WP_073694769.1|4684621_4684849_+|PAS-domain-containing-protein
MLHSNTINHELHVRHAPEAIITATVDGLITGWNIAAERLFGRSVADSLGQLIRDALGVELDVVAIAAEGRARDLT
>NZ_AP022616.1|WP_082761734.1|4684218_4684644_+|PAS-domain-containing-protein
MHNNHATGHDSGTSWNVSVGASAASFRSLSETSPYAVLVHDRGRVVYANAAAASLTMAESTGQMVGAHHRLCASRSNFERLDRSRRLRPGIGTSDVGFAALRWNHARHRSHHGSHPVGRSPRPSDGAASGDHANSVAQQYN
>NZ_AP022616.1|WP_064860949.1|4682924_4683566_+|hypothetical-protein
MAVTLLDGLCKLSDGDDSDNETSEFAHLLRGWIREYLMEPHRDLGRAGPVCPFARASLDQDMLWITAVHSELPAFSKLVAELHTLRDTFLELEPADGPESLLKAVFIVFPDLTDVAVIDAVQQALKPEFVDAGLMVGQFYDGCTERGLWNADFRPLQSPVPLLAIRHMVGSDFAFLNTSPAWVEAYLRRFAPTVPSPVRAALADRFSDPTPPG
>NZ_AP022616.1|WP_073694771.1|4681621_4682854_-|ATP-grasp-domain-containing-protein
MSVPTERRIAIVYEPDSVPLLILTETATRNGIHLVWLAGQTDARILRRFGSVVITDGSSTEKVTAQLTLHDVVGVTTFADSRIEHAAALARNIGLPANHACTARLLVDKIAQRHALADAGVPGPGFVGIDSPARATSADELLKKLTYPVVVKPASGHGGRDTICIPDFPALAAELAIRCHANPWRPTIIEELLGDFPPTDRGGVGDYVSVEVVVDNGLPSVLAITGRMPLAEPFRETGAFLPAILSPVERHDVADVALKAALALDVQCGCLHIEIKLTTTGPHIIEVNGRVPGGGITDLVAAQTGIDLFECALNSAAGQIVDRRPGNAAGVHYQLALQPPIGQRVRLRPDWSAQLRTVAGIEHVALRSMTAEVDLRDGSYGYLLMARGCADDHEGLLETHRRLNTLLLND
>NZ_AP022616.1|WP_064860937.1|4681117_4681597_-|hypothetical-protein
MTELHARVRAHLAAAAVTHRVHDHAALPGPISSPTDFAAALGYPVDRIMKTLICHEHSTGRLIAVTCPVNIRVDLKRVATELGCSRIEVASSVQLEATTGYPRLGVSPLGLDPSFIVVIAQHTLTYDTVLVGGGAAGIEIELAPRDLQRTTDAVPVDLR
>NZ_AP022616.1|WP_138250719.1|4680461_4680920_-|hypothetical-protein
MSREGEMVFLDDVLVQHAGRLRQNTGLSIRTDLQPTYVVGDATTLNRAVTALVEHARCNAVSAIELEVYRRDAQAVIIIRDDGPHIAVADTGRMSSKCNSGLELAARIIATHGGTLALGERGACTNAVSVRLPSTRQSLFNSPAPKWISDGQ
>NZ_AP022616.1|WP_133427884.1|4678932_4680261_-|HAMP-domain-containing-histidine-kinase
MVAAAVVLAGLVIVGSASTLLLYRMMCADVDNAAEARAQAVADVLRKEPPDEVESVLMHTDHRIVAVQIADAAGTVVERSDSAPQTPLIPVPHEGAQVGVLATDDDDVRVSTITVASRKGRQYTVLVGGGIEPIEQMIGTAGQMLAITAPVVAVVAGVVTYLLVRRSLRSVEAIRSRVSAISAFDLGERVPVGRRSDEISALAVTMNDMLARIEAGHAAQRRFVGDASHELRSPLATVVSALEIGATHPDLLDRTLLTNALLPEARRMQTLVENLLLLARADERGLPLRRVETDLDDLATAEAARLKRETTLRIVSDLSAVKASVDPDGFVRLLRNLADNAARHATSEVTIVVRAEGDNAVVQVIDDGPGIPAAARDKVFERFFRLDADRSRRGGGTGLGLAIVSEIVAAHDGSVSIEDRRSGAGTVVTVQLPLAGSPDSSR
>NZ_AP022616.1|WP_061003619.1|4678294_4678972_+|response-regulator-transcription-factor
MRVLLVEDEPMLAETITAGLRAEGFVVVAVADGAEGLWQATHEQFDVIVLDIMLPGLNGYEVLRKMRAAHIWTPVLMLTAKDGDYDQTDAFDLGADDYLTKPFSFMVLTARLRALIRRGAPQRPVVLTAGDISLDPARRTVHRGGEDVSLTPREFALLAYLLRHKDTVLTKTQILHNVWDSHYDGPDNVVEVYVGYLRRKIGSEAITTLRGAGYRLESGEPASGN
>NZ_AP022616.1|WP_165605570.1|4678092_4678248_+|hypothetical-protein
MTARREAINLMVGALMLVAATMSVHEAQERAQNAPALSNGGHYDSALVQGM
>NZ_AP022616.1|WP_138250718.1|4690288_4691761_+|M28-family-peptidase
MVRTRVALALVLAVGISGCGRSEPTADDFAGELSKSVTVEATTGHLAKLQAIADAHGGNRAFGTPGYDASVDYVANALRAKGFDVVTPDMEVKVAYNNTPELTVAGTRIPARALEYSVGTPGLTAPLVPVKGGPASGCNSADYDGLPIKGAVALVDRGTCPFAVKEATAAVHGAVALVVADNKDDVDDAGVPARGGTLGAKATVRIPAVLISKAAGARLRAAPGPVSLKLDAGVRVEHTRNVIAQTKTGSEHDVVMVGAHLDSVKEGPGINDNGSGVTAVLETALQLGSAPQIANAVRFAFWGAEEEGTIGSDRYIESLDVEALKDIALYLNFDMLASENAGYFSYDGNLSGPPLADDLVPRIPEGSAGIDRTFTAYLSDAGKPPQDYPFNGRSDYDAFTKAGIPAGGLGTGDEENMNDEQARLWGGTAGKPFDSNYHKKTDDLAHINRTAMDIMGRGVAFGVGRYAQDLSGRNGVPVRDDRTRHVVSAS
>NZ_AP022616.1|WP_061002140.1|4691757_4693233_+|M28-family-peptidase
MRRALAAGLLTAVLASCAPPPQPPAPPPPPAPDLARDLAGRVGTDGIYTHLRKFAAIAAENKGTRADGTPGYQASVDYVANLLRDKGFDVQTPEYVRVERGAPGNPVLDVGGRRWGVVQASLLTSTAPGGLTAPTLHPVKPAGCAPDDYGTLNLRGAIAVVDDAVCSVVDKQNAAVARGAVAVLVVSPPSANGAPRGLFSPGYYEHLNTPVGIIGKDADAVLLKTNSPVKLTLDAKNTGVKSRNVLAQTKTGDQHSVVLAGAHLDSAPTSAGINDAATGVSALLETAAALGGSPKIENAVRFTFWGSGAVGQEGATKYVRGLAAEPLNDIALYLDFDILGSPNAGFFTFDGDQSGQANPEIPLDAVPAGSAGLERTLAGYLYLAGKRPADMTMDLGSGYGPFLTAGIPVGGISTGTSQRKSPIQARLWGGQAGAAFDPGYGPKGDTVEQLNRAALAVTGPTVAFAVGTYAQSLTGPNGVPLHDERHRQAGK
>NZ_AP022616.1|WP_162563420.1|4693315_4693720_+|hypothetical-protein
MKSTYRRWSAVAGTVTVVAMGGLTVACGSQGNNAPATVTVTPSSTTTTTTTAKQHHGGGGGGSAGGGQQQAPAPAPETVTNTETATQTETQTQTETSTSVQTSTETSTSVQTSTVYQPQPRERGGFNNFGPQQH
>NZ_AP022616.1|WP_061002165.1|4693793_4694426_+|GntR-family-transcriptional-regulator
MDQTPASERAYRDTKSKILVGAVKGGQLLSEVAVAAELGVSRTPVHEAFLRLAAEDLLDLLPRRGAVVVPISPREATDLLEMRLALEGSAVRRLCRSEATAQAVAAELARLIDQQRGAATDLARFAELDDAFHRHIVDSAGNCIAQRFYGSLGDRQRRMMADAVQADQTLVERLIAEHAELAQAIDVRDATAFDARLLAHLESTYEVVLR
>NZ_AP022616.1|WP_138250717.1|4694422_4695628_+|MFS-transporter
MSRARVKPWLAVAAGVFCIGWGGNQFTPMLIEYVHRAGYSRVDVDVLLGAYVLGLIPGLLVAAAMSNRYGRRPLMVAGLISSALGSLILATGELGGFPALFVGRLLCGLSVGVAMAVGSTWIAELSAPPYDTAATGAGARRASIWLSLGLAIGPLCSGLLAQFAPLPLTLTYLVQAALCVPALWLVLTRTVETRGARVSGDLLSQLRVPAATHRRFVRVVAPMAPWVFGSAAIAYAIVPALVADRLGSWALLYTAGLTVLTLACGVLVQPVARRLDDHSSARAVVVSMVLMSAGVFAAVATAVTRSPAIAVLVAMLLGSAYGIAIVSGLLEIQRIAEPHELAGVSGVYYSLAYVGFLLPAVLAALAHYVSYPAMLTVVGLLAAVCTVICAAGWSKHLPARA
>NZ_AP022616.1|WP_138250716.1|4695687_4695966_-|hypothetical-protein
MTDAAENTAGKKGLLAGIGLALAGLAHFVKPDLFRGIVTMAFPSDIDKHLQINGSIETALGVGLIVPQTRKLATIGVIGYGLYLAANVFRNR
>NZ_AP022616.1|WP_138250715.1|4695982_4697470_-|NAD(P)/FAD-dependent-oxidoreductase
MTTQQFDAVIVGAGFAGIGAAIQLKRLGIENFTILEREDDLGGTWYVNHYPGLAVDVPTTTYSYFFEPNPNWSRLFTPGPEIKRYADDVAAKYDVRRHIRFNVVVNGARWDEEASLWRVNIADGETLSARYLITATGFLSQPNIPAIPGIESFEGRVIHTTDWDDDYDPAGKRVAVIGTGATAVQLIPELAKTAADLTVFQRTPIWVVPKIDPRFGARAKKMFARFPLTQRVLRWLTDSIYEVMVSVGVRHYGMFRGRFNISASDLSKMHRFFVIRDKDLRRRLTPDYDFGCKRPTFSNGYYQAFNRPNVHLQDAGIDRIEADGILGNDGVKVEIDTLVLATGFDLWEANFPAIEVIGREGRDLGKWWRETRFQAYQGVSMPYFPNYLSLASPYAFLGLNFFNTMEYQMRLMDRLFTEVKARGATTFEVTEEANTAFLDRMTELLGDSLFTLGNCASAHSYYFNPAGEPTLLRPSSTETAIREASEFPLSDYKIS
>NZ_AP022616.1|WP_138250714.1|4697484_4698111_-|alpha/beta-hydrolase
MSLEDIAGIAHEPDGTPTGVVLLTHGAGGNRDAPLIIRLCDEWARHGWLAIRYNLPYRRRRPKGPPSNSAASDQQGIVEAIELAHTLTDGPVIAGGHSYGGRMTSMVAAQGADLAALTLFSYPLHPPGKPERARTEHLGQIKVPTVFTHGTADPFGSIDELTAAAQLIPAPTELIEITGARHDLGSKTLDVPALAVAAALVFVARSGT
>NZ_AP022616.1|WP_138250713.1|4698113_4698971_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MSFLPLTPPGETPLRVMTIAGSDSGGGAGIQADLRTFAMLGVHGCVAVAAVTVQNSVGVKGFHELPLDIISGQITAVADDIGIQAAKTGMLASAEIIGAVADTWQSLDGDIPLVVDPVCASMHGDPLLHPSALNSVRTQLFPIATLVTPNLDEVRLITGIDVVDAATQRDAAKALYDLGPKWALVKGGHLRSSDHSPDLLYDGNEFYEFTTERIDTGHDHGAGDTLAASTACALAHGFSVPDAVAFGKSWVTECLRAAYPLGRGHGPVNALFRLADERSREDDRA
>NZ_AP022616.1|WP_138250712.1|4698967_4700590_-|phosphomethylpyrimidine-synthase-ThiC
MTAIAVFNDLSCGPIQGSTKVYRELPDGGKVPFRRVNLTTGDHLDLYDTSGPYTDETATIDLEKGLPARPGVVKDRGTQLQRARNGEITAEMAFIAEREGVPAELVRDEVAIGRAIIPANHNHPELEPMIIGKAFAVKVNANIGNSAVTSSISEEVDKMVWATRWGADTIMDLSTGKDIHMTREWILRNSPVPVGTVPIYQALEKVNGDPTKLTWELYRDTVIEQCEQGVDYMTVHAGVLLRYIPLTVKRVTGIVSRGGSIMAAWCLAHHQESFLYTHFEELCEILQRYDVTFSLGDGLRPGSIADANDEAQFAELRTLGELTKIAKSHGVQVMIEGPGHVPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAIIAQAGTAMLCYVTPKEHLGLPNRKDVKDGVIAYKIAAHAADLAKGHPGAQDRDNALSQARFEFRWHDQFALSLDPDTAREYHDETLPAEPAKTAHFCSMCGPKFCSMRITQDIRDAYPDGVAPDFADEIAQGMAEKSQEFADHGNRVYLPLAP

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Crispr_ID: NZ_AP022616_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022616_7

4687387-4687943

Orphan

Consensus_repeat	Method
GGCGGCACTGGTGGCACCGGTGG	CRISPRCasFinder

11 spacers

The CRISPR arrays of NZ_AP022616_7

>merge|NZ_AP022616|7|4687387-4687943|CRISPRCasFinder
GGCGGCACTGGTGGCACCGGTGGTGCGGGCGCCGCGGGTGGCGCGGGTGCTTCAGGCGGCACTGGTGGTACCGGTGGCACTGGCGGAACCGGTGGCACCGGCGGAACCGGTGGTGCCGGTACGCCGGGCGGCTCCGGCGGCGGCGGTGGTGCCGGTGGGACGGGTCTGCAGGGTACTGCGGCCGGTGCCGGTGGTGCCGGTGGTGCCGGTGGCAGTGCCGGCCTGCTCACGTTGTTCGGTGGCGGCGGCCAAGGTGGTGACGGCGGTATTGGTGGCACCGGCGGAACCGGTGGCACCGGCGGTTCGGGTGGCACCGGCGGCACGGGTGGCAATGGTGGCAATGGTGGCGCAGGCGGCAATGGTGGCGCAGGCGGCACGGGCGGTTCCGGTGGGACTGGTGGCACGGGCGGTACCGGCGGTACCGGCGGTACCGGTGGCGCCGGTGGCGACGGCATCTCGCCGATTGCCCCGCTGCCCTTCGCGATCGCAGGTGGTGCGGGTGGCACCGGCGGTGCGGGTGGTAAGGGTGGCACCGGCGGTACGGGTGGTACCGGCGG

>NZ_AP022616|7|7|4687387-4687943|CRISPRCasFinder
GGCGGCACTGGTGGCACCGGTGG	TGCGGGCGCCGCGGGTGGCGCG
GGTGCTTCAGGCGGCACTGGTGG	TACCGGTGGCACTGGCGGAACC
GGTGGCACCGGCGGAACCGGTGG	TGCCGGTACGCCGGGCGGCTCC
GGCGGCGGCGGTGGTGCCGGTGG	GACGGGTCTGCAGGGTACTGCG
GCCGGTGCCGGTGGTGCCGGTGG	TGCCGGTGGCAGTGCCGGCCTGCTCACGTTGTTCGGTGGC
GGCGGCCAAGGTGGTGACGGCGG	TATTGGTGGCACCGGCGGAACC
GGTGGCACCGGCGGTTCGGGTGG	CACCGGCGGCACGGGTGGCAAT
GGTGGCAATGGTGGCGCAGGCGG	CAATGGTGGCGCAGGCGGCACG
GGCGGTTCCGGTGGGACTGGTGG	CACGGGCGGTACCGGCGGTACC
GGCGGTACCGGTGGCGCCGGTGG	CGACGGCATCTCGCCGATTGCCCCGCTGCCCTTCGCGATCGCA
GGTGGTGCGGGTGGCACCGGCGG	TGCGGGTGGTAAGGGTGGCACC
GGCGGTACGGGTGGTACCGGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022616.1\|WP_138250712.1\|4698967_4700590_-\|phosphomethylpyrimidine-synthase-ThiC	unknown	unknown	gnl\|CDD\|236451
NZ_AP022616.1\|WP_073694769.1\|4684621_4684849_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|366402
NZ_AP022616.1\|WP_061003619.1\|4678294_4678972_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_AP022616.1\|WP_138250719.1\|4680461_4680920_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236846
NZ_AP022616.1\|WP_064860949.1\|4682924_4683566_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022616.1\|WP_138250718.1\|4690288_4691761_+\|M28-family-peptidase	unknown	unknown	gnl\|CDD\|349873
NZ_AP022616.1\|WP_082761734.1\|4684218_4684644_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|379059
NZ_AP022616.1\|WP_162563420.1\|4693315_4693720_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226406
NZ_AP022616.1\|WP_138250715.1\|4695982_4697470_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224983
NZ_AP022616.1\|WP_138250714.1\|4697484_4698111_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|226101
NZ_AP022616.1\|WP_061002165.1\|4693793_4694426_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_AP022616.1\|WP_064860937.1\|4681117_4681597_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237976
NZ_AP022616.1\|WP_138250717.1\|4694422_4695628_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NZ_AP022616.1\|WP_165605570.1\|4678092_4678248_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022616.1\|WP_073694771.1\|4681621_4682854_-\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|235010
NZ_AP022616.1\|WP_133427884.1\|4678932_4680261_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_AP022616.1\|WP_138250716.1\|4695687_4695966_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226720
NZ_AP022616.1\|WP_061002140.1\|4691757_4693233_+\|M28-family-peptidase	unknown	unknown	gnl\|CDD\|349873
NZ_AP022616.1\|WP_163692956.1\|4685169_4685919_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_AP022616.1\|WP_138250713.1\|4698113_4698971_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|180561

Protein	Function_ID	Function_description	E-value
NZ_AP022616.1\|WP_138250712.1\|4698967_4700590_-\|phosphomethylpyrimidine-synthase-ThiC	gnl\|CDD\|236451	PRK09284, PRK09284, thiamine biosynthesis protein ThiC; Provisional.	0
NZ_AP022616.1\|WP_073694769.1\|4684621_4684849_+\|PAS-domain-containing-protein	gnl\|CDD\|366402	pfam00989, PAS, PAS fold. The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.	8.70585e-06
NZ_AP022616.1\|WP_061003619.1\|4678294_4678972_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.03559e-84
NZ_AP022616.1\|WP_138250718.1\|4690288_4691761_+\|M28-family-peptidase	gnl\|CDD\|349873	cd03876, M28_SGAP_like, M28 Zn-peptidase Streptomyces griseus aminopeptidase and similar proteins. Peptidase family M28; Streptomyces griseus Aminopeptidase (SGAP, Leucine aminopeptidase (LAP), aminopeptidase S, Mername-AA022 peptidase) subfamily. SGAP is a di-zinc exopeptidase with high preference towards large hydrophobic amino-terminal residues, with Leu being the most efficiently cleaved. It can accommodate all except Pro and Glu residues in the P1' position. It is a monomeric (30 kDa), calcium-activated and calcium-stabilized enzyme; its activation by calcium correlates with substrate specificity and it has thermal stability only in the presence of calcium. Although SGAP contains a calcium binding site, it is not conserved in many members of this subfamily. SGAP is present in the extracellular fluid of S. griseus cultures.	1.71093e-106
NZ_AP022616.1\|WP_082761734.1\|4684218_4684644_+\|PAS-domain-containing-protein	gnl\|CDD\|379059	pfam13188, PAS_8, PAS domain.	0.000140775
NZ_AP022616.1\|WP_162563420.1\|4693315_4693720_+\|hypothetical-protein	gnl\|CDD\|226406	COG3889, COG3889, Predicted solute binding protein [General function prediction only].	2.94253e-05
NZ_AP022616.1\|WP_138250715.1\|4695982_4697470_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224983	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism].	1.19064e-99
NZ_AP022616.1\|WP_138250714.1\|4697484_4698111_-\|alpha/beta-hydrolase	gnl\|CDD\|226101	COG3571, COG3571, Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only].	3.44444e-69
NZ_AP022616.1\|WP_061002165.1\|4693793_4694426_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	9.92145e-33
NZ_AP022616.1\|WP_064860937.1\|4681117_4681597_-\|hypothetical-protein	gnl\|CDD\|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	8.27643e-30
NZ_AP022616.1\|WP_138250717.1\|4694422_4695628_+\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.38484e-20
NZ_AP022616.1\|WP_138250719.1\|4680461_4680920_-\|hypothetical-protein	gnl\|CDD\|236846	PRK11100, PRK11100, sensory histidine kinase CreC; Provisional.	2.76328e-07
NZ_AP022616.1\|WP_073694771.1\|4681621_4682854_-\|ATP-grasp-domain-containing-protein	gnl\|CDD\|235010	PRK02186, PRK02186, argininosuccinate lyase; Provisional.	1.37025e-23
NZ_AP022616.1\|WP_133427884.1\|4678932_4680261_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.37059e-45
NZ_AP022616.1\|WP_138250716.1\|4695687_4695966_-\|hypothetical-protein	gnl\|CDD\|226720	COG4270, COG4270, Predicted membrane protein [Function unknown].	3.97323e-06
NZ_AP022616.1\|WP_061002140.1\|4691757_4693233_+\|M28-family-peptidase	gnl\|CDD\|349873	cd03876, M28_SGAP_like, M28 Zn-peptidase Streptomyces griseus aminopeptidase and similar proteins. Peptidase family M28; Streptomyces griseus Aminopeptidase (SGAP, Leucine aminopeptidase (LAP), aminopeptidase S, Mername-AA022 peptidase) subfamily. SGAP is a di-zinc exopeptidase with high preference towards large hydrophobic amino-terminal residues, with Leu being the most efficiently cleaved. It can accommodate all except Pro and Glu residues in the P1' position. It is a monomeric (30 kDa), calcium-activated and calcium-stabilized enzyme; its activation by calcium correlates with substrate specificity and it has thermal stability only in the presence of calcium. Although SGAP contains a calcium binding site, it is not conserved in many members of this subfamily. SGAP is present in the extracellular fluid of S. griseus cultures.	1.73225e-81
NZ_AP022616.1\|WP_163692956.1\|4685169_4685919_+\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	5.04101e-55
NZ_AP022616.1\|WP_138250713.1\|4698113_4698971_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl\|CDD\|180561	PRK06427, PRK06427, bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed.	5.66931e-140

>NZ_AP022616.1|WP_163692956.1|4685169_4685919_+|diguanylate-cyclase
MRTGQPVYAQVLGLRRDDGHQSWISFTTTLLNPDEPERSPIVMSLTDVTTEHLTNLHLRRAAHHDTLTGLPNRGRALAMITAAMTPSDHPHLAALMFIDIDQLKRINDSLGHHVGDVVLQACAERLQGAIRATDTLARVGGDEFVVLVAAPASAADLQQIARRLHHALENPIVTDEHTIAVSASIGVAGVDPTRPTTPTDLLRQADAAMYQAKATGSGETRFLSVHSATPRHRSDADPRHSSTPPERRL
>NZ_AP022616.1|WP_073694769.1|4684621_4684849_+|PAS-domain-containing-protein
MLHSNTINHELHVRHAPEAIITATVDGLITGWNIAAERLFGRSVADSLGQLIRDALGVELDVVAIAAEGRARDLT
>NZ_AP022616.1|WP_082761734.1|4684218_4684644_+|PAS-domain-containing-protein
MHNNHATGHDSGTSWNVSVGASAASFRSLSETSPYAVLVHDRGRVVYANAAAASLTMAESTGQMVGAHHRLCASRSNFERLDRSRRLRPGIGTSDVGFAALRWNHARHRSHHGSHPVGRSPRPSDGAASGDHANSVAQQYN
>NZ_AP022616.1|WP_064860949.1|4682924_4683566_+|hypothetical-protein
MAVTLLDGLCKLSDGDDSDNETSEFAHLLRGWIREYLMEPHRDLGRAGPVCPFARASLDQDMLWITAVHSELPAFSKLVAELHTLRDTFLELEPADGPESLLKAVFIVFPDLTDVAVIDAVQQALKPEFVDAGLMVGQFYDGCTERGLWNADFRPLQSPVPLLAIRHMVGSDFAFLNTSPAWVEAYLRRFAPTVPSPVRAALADRFSDPTPPG
>NZ_AP022616.1|WP_073694771.1|4681621_4682854_-|ATP-grasp-domain-containing-protein
MSVPTERRIAIVYEPDSVPLLILTETATRNGIHLVWLAGQTDARILRRFGSVVITDGSSTEKVTAQLTLHDVVGVTTFADSRIEHAAALARNIGLPANHACTARLLVDKIAQRHALADAGVPGPGFVGIDSPARATSADELLKKLTYPVVVKPASGHGGRDTICIPDFPALAAELAIRCHANPWRPTIIEELLGDFPPTDRGGVGDYVSVEVVVDNGLPSVLAITGRMPLAEPFRETGAFLPAILSPVERHDVADVALKAALALDVQCGCLHIEIKLTTTGPHIIEVNGRVPGGGITDLVAAQTGIDLFECALNSAAGQIVDRRPGNAAGVHYQLALQPPIGQRVRLRPDWSAQLRTVAGIEHVALRSMTAEVDLRDGSYGYLLMARGCADDHEGLLETHRRLNTLLLND
>NZ_AP022616.1|WP_064860937.1|4681117_4681597_-|hypothetical-protein
MTELHARVRAHLAAAAVTHRVHDHAALPGPISSPTDFAAALGYPVDRIMKTLICHEHSTGRLIAVTCPVNIRVDLKRVATELGCSRIEVASSVQLEATTGYPRLGVSPLGLDPSFIVVIAQHTLTYDTVLVGGGAAGIEIELAPRDLQRTTDAVPVDLR
>NZ_AP022616.1|WP_138250719.1|4680461_4680920_-|hypothetical-protein
MSREGEMVFLDDVLVQHAGRLRQNTGLSIRTDLQPTYVVGDATTLNRAVTALVEHARCNAVSAIELEVYRRDAQAVIIIRDDGPHIAVADTGRMSSKCNSGLELAARIIATHGGTLALGERGACTNAVSVRLPSTRQSLFNSPAPKWISDGQ
>NZ_AP022616.1|WP_133427884.1|4678932_4680261_-|HAMP-domain-containing-histidine-kinase
MVAAAVVLAGLVIVGSASTLLLYRMMCADVDNAAEARAQAVADVLRKEPPDEVESVLMHTDHRIVAVQIADAAGTVVERSDSAPQTPLIPVPHEGAQVGVLATDDDDVRVSTITVASRKGRQYTVLVGGGIEPIEQMIGTAGQMLAITAPVVAVVAGVVTYLLVRRSLRSVEAIRSRVSAISAFDLGERVPVGRRSDEISALAVTMNDMLARIEAGHAAQRRFVGDASHELRSPLATVVSALEIGATHPDLLDRTLLTNALLPEARRMQTLVENLLLLARADERGLPLRRVETDLDDLATAEAARLKRETTLRIVSDLSAVKASVDPDGFVRLLRNLADNAARHATSEVTIVVRAEGDNAVVQVIDDGPGIPAAARDKVFERFFRLDADRSRRGGGTGLGLAIVSEIVAAHDGSVSIEDRRSGAGTVVTVQLPLAGSPDSSR
>NZ_AP022616.1|WP_061003619.1|4678294_4678972_+|response-regulator-transcription-factor
MRVLLVEDEPMLAETITAGLRAEGFVVVAVADGAEGLWQATHEQFDVIVLDIMLPGLNGYEVLRKMRAAHIWTPVLMLTAKDGDYDQTDAFDLGADDYLTKPFSFMVLTARLRALIRRGAPQRPVVLTAGDISLDPARRTVHRGGEDVSLTPREFALLAYLLRHKDTVLTKTQILHNVWDSHYDGPDNVVEVYVGYLRRKIGSEAITTLRGAGYRLESGEPASGN
>NZ_AP022616.1|WP_165605570.1|4678092_4678248_+|hypothetical-protein
MTARREAINLMVGALMLVAATMSVHEAQERAQNAPALSNGGHYDSALVQGM
>NZ_AP022616.1|WP_138250718.1|4690288_4691761_+|M28-family-peptidase
MVRTRVALALVLAVGISGCGRSEPTADDFAGELSKSVTVEATTGHLAKLQAIADAHGGNRAFGTPGYDASVDYVANALRAKGFDVVTPDMEVKVAYNNTPELTVAGTRIPARALEYSVGTPGLTAPLVPVKGGPASGCNSADYDGLPIKGAVALVDRGTCPFAVKEATAAVHGAVALVVADNKDDVDDAGVPARGGTLGAKATVRIPAVLISKAAGARLRAAPGPVSLKLDAGVRVEHTRNVIAQTKTGSEHDVVMVGAHLDSVKEGPGINDNGSGVTAVLETALQLGSAPQIANAVRFAFWGAEEEGTIGSDRYIESLDVEALKDIALYLNFDMLASENAGYFSYDGNLSGPPLADDLVPRIPEGSAGIDRTFTAYLSDAGKPPQDYPFNGRSDYDAFTKAGIPAGGLGTGDEENMNDEQARLWGGTAGKPFDSNYHKKTDDLAHINRTAMDIMGRGVAFGVGRYAQDLSGRNGVPVRDDRTRHVVSAS
>NZ_AP022616.1|WP_061002140.1|4691757_4693233_+|M28-family-peptidase
MRRALAAGLLTAVLASCAPPPQPPAPPPPPAPDLARDLAGRVGTDGIYTHLRKFAAIAAENKGTRADGTPGYQASVDYVANLLRDKGFDVQTPEYVRVERGAPGNPVLDVGGRRWGVVQASLLTSTAPGGLTAPTLHPVKPAGCAPDDYGTLNLRGAIAVVDDAVCSVVDKQNAAVARGAVAVLVVSPPSANGAPRGLFSPGYYEHLNTPVGIIGKDADAVLLKTNSPVKLTLDAKNTGVKSRNVLAQTKTGDQHSVVLAGAHLDSAPTSAGINDAATGVSALLETAAALGGSPKIENAVRFTFWGSGAVGQEGATKYVRGLAAEPLNDIALYLDFDILGSPNAGFFTFDGDQSGQANPEIPLDAVPAGSAGLERTLAGYLYLAGKRPADMTMDLGSGYGPFLTAGIPVGGISTGTSQRKSPIQARLWGGQAGAAFDPGYGPKGDTVEQLNRAALAVTGPTVAFAVGTYAQSLTGPNGVPLHDERHRQAGK
>NZ_AP022616.1|WP_162563420.1|4693315_4693720_+|hypothetical-protein
MKSTYRRWSAVAGTVTVVAMGGLTVACGSQGNNAPATVTVTPSSTTTTTTTAKQHHGGGGGGSAGGGQQQAPAPAPETVTNTETATQTETQTQTETSTSVQTSTETSTSVQTSTVYQPQPRERGGFNNFGPQQH
>NZ_AP022616.1|WP_061002165.1|4693793_4694426_+|GntR-family-transcriptional-regulator
MDQTPASERAYRDTKSKILVGAVKGGQLLSEVAVAAELGVSRTPVHEAFLRLAAEDLLDLLPRRGAVVVPISPREATDLLEMRLALEGSAVRRLCRSEATAQAVAAELARLIDQQRGAATDLARFAELDDAFHRHIVDSAGNCIAQRFYGSLGDRQRRMMADAVQADQTLVERLIAEHAELAQAIDVRDATAFDARLLAHLESTYEVVLR
>NZ_AP022616.1|WP_138250717.1|4694422_4695628_+|MFS-transporter
MSRARVKPWLAVAAGVFCIGWGGNQFTPMLIEYVHRAGYSRVDVDVLLGAYVLGLIPGLLVAAAMSNRYGRRPLMVAGLISSALGSLILATGELGGFPALFVGRLLCGLSVGVAMAVGSTWIAELSAPPYDTAATGAGARRASIWLSLGLAIGPLCSGLLAQFAPLPLTLTYLVQAALCVPALWLVLTRTVETRGARVSGDLLSQLRVPAATHRRFVRVVAPMAPWVFGSAAIAYAIVPALVADRLGSWALLYTAGLTVLTLACGVLVQPVARRLDDHSSARAVVVSMVLMSAGVFAAVATAVTRSPAIAVLVAMLLGSAYGIAIVSGLLEIQRIAEPHELAGVSGVYYSLAYVGFLLPAVLAALAHYVSYPAMLTVVGLLAAVCTVICAAGWSKHLPARA
>NZ_AP022616.1|WP_138250716.1|4695687_4695966_-|hypothetical-protein
MTDAAENTAGKKGLLAGIGLALAGLAHFVKPDLFRGIVTMAFPSDIDKHLQINGSIETALGVGLIVPQTRKLATIGVIGYGLYLAANVFRNR
>NZ_AP022616.1|WP_138250715.1|4695982_4697470_-|NAD(P)/FAD-dependent-oxidoreductase
MTTQQFDAVIVGAGFAGIGAAIQLKRLGIENFTILEREDDLGGTWYVNHYPGLAVDVPTTTYSYFFEPNPNWSRLFTPGPEIKRYADDVAAKYDVRRHIRFNVVVNGARWDEEASLWRVNIADGETLSARYLITATGFLSQPNIPAIPGIESFEGRVIHTTDWDDDYDPAGKRVAVIGTGATAVQLIPELAKTAADLTVFQRTPIWVVPKIDPRFGARAKKMFARFPLTQRVLRWLTDSIYEVMVSVGVRHYGMFRGRFNISASDLSKMHRFFVIRDKDLRRRLTPDYDFGCKRPTFSNGYYQAFNRPNVHLQDAGIDRIEADGILGNDGVKVEIDTLVLATGFDLWEANFPAIEVIGREGRDLGKWWRETRFQAYQGVSMPYFPNYLSLASPYAFLGLNFFNTMEYQMRLMDRLFTEVKARGATTFEVTEEANTAFLDRMTELLGDSLFTLGNCASAHSYYFNPAGEPTLLRPSSTETAIREASEFPLSDYKIS
>NZ_AP022616.1|WP_138250714.1|4697484_4698111_-|alpha/beta-hydrolase
MSLEDIAGIAHEPDGTPTGVVLLTHGAGGNRDAPLIIRLCDEWARHGWLAIRYNLPYRRRRPKGPPSNSAASDQQGIVEAIELAHTLTDGPVIAGGHSYGGRMTSMVAAQGADLAALTLFSYPLHPPGKPERARTEHLGQIKVPTVFTHGTADPFGSIDELTAAAQLIPAPTELIEITGARHDLGSKTLDVPALAVAAALVFVARSGT
>NZ_AP022616.1|WP_138250713.1|4698113_4698971_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MSFLPLTPPGETPLRVMTIAGSDSGGGAGIQADLRTFAMLGVHGCVAVAAVTVQNSVGVKGFHELPLDIISGQITAVADDIGIQAAKTGMLASAEIIGAVADTWQSLDGDIPLVVDPVCASMHGDPLLHPSALNSVRTQLFPIATLVTPNLDEVRLITGIDVVDAATQRDAAKALYDLGPKWALVKGGHLRSSDHSPDLLYDGNEFYEFTTERIDTGHDHGAGDTLAASTACALAHGFSVPDAVAFGKSWVTECLRAAYPLGRGHGPVNALFRLADERSREDDRA
>NZ_AP022616.1|WP_138250712.1|4698967_4700590_-|phosphomethylpyrimidine-synthase-ThiC
MTAIAVFNDLSCGPIQGSTKVYRELPDGGKVPFRRVNLTTGDHLDLYDTSGPYTDETATIDLEKGLPARPGVVKDRGTQLQRARNGEITAEMAFIAEREGVPAELVRDEVAIGRAIIPANHNHPELEPMIIGKAFAVKVNANIGNSAVTSSISEEVDKMVWATRWGADTIMDLSTGKDIHMTREWILRNSPVPVGTVPIYQALEKVNGDPTKLTWELYRDTVIEQCEQGVDYMTVHAGVLLRYIPLTVKRVTGIVSRGGSIMAAWCLAHHQESFLYTHFEELCEILQRYDVTFSLGDGLRPGSIADANDEAQFAELRTLGELTKIAKSHGVQVMIEGPGHVPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAIIAQAGTAMLCYVTPKEHLGLPNRKDVKDGVIAYKIAAHAADLAKGHPGAQDRDNALSQARFEFRWHDQFALSLDPDTAREYHDETLPAEPAKTAHFCSMCGPKFCSMRITQDIRDAYPDGVAPDFADEIAQGMAEKSQEFADHGNRVYLPLAP

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_AP022616_5	5.1\|4562337\|19\|NZ_AP022616\|CRISPRCasFinder	4562337-4562355	19	NZ_AP022616.1	1103260-1103278	2	0.895
NZ_AP022616_5	5.1\|4562337\|19\|NZ_AP022616\|CRISPRCasFinder	4562337-4562355	19	NZ_AP022616.1	2565297-2565315	2	0.895
NZ_AP022616_5	5.1\|4562337\|19\|NZ_AP022616\|CRISPRCasFinder	4562337-4562355	19	NZ_AP022616.1	3418031-3418049	2	0.895
NZ_AP022616_5	5.1\|4562337\|19\|NZ_AP022616\|CRISPRCasFinder	4562337-4562355	19	NZ_AP022616.1	4432242-4432260	2	0.895

1. spacer 5.1|4562337|19|NZ_AP022616|CRISPRCasFinder matches to position: 1103260-1103278, mismatch: 2, identity: 0.895

gctcggtcagatgggccag	CRISPR spacer
gctcggtcacatgggtcag	Protospacer
********* *****.***

2. spacer 5.1|4562337|19|NZ_AP022616|CRISPRCasFinder matches to position: 2565297-2565315, mismatch: 2, identity: 0.895

gctcggtcagatgggccag	CRISPR spacer
gctcgggcaggtgggccag	Protospacer
****** ***.********

3. spacer 5.1|4562337|19|NZ_AP022616|CRISPRCasFinder matches to position: 3418031-3418049, mismatch: 2, identity: 0.895

gctcggtcagatgggccag	CRISPR spacer
gctcggtcagataggcgag	Protospacer
************.*** **

4. spacer 5.1|4562337|19|NZ_AP022616|CRISPRCasFinder matches to position: 4432242-4432260, mismatch: 2, identity: 0.895

gctcggtcagatgggccag	CRISPR spacer
gctcggtcagcggggccag	Protospacer
**********  *******

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP022616_7	7.9\|4687788\|22\|NZ_AP022616\|CRISPRCasFinder	4687788-4687809	22	NZ_LR134459	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 17, complete sequence	83116-83137	0	1.0
NZ_AP022616_7	7.1\|4687410\|22\|NZ_AP022616\|CRISPRCasFinder	4687410-4687431	22	NZ_CP030263	Ensifer adhaerens strain Corn53 plasmid AA, complete sequence	1606891-1606912	1	0.955
NZ_AP022616_7	7.1\|4687410\|22\|NZ_AP022616\|CRISPRCasFinder	4687410-4687431	22	NZ_CP016452	Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence	1264489-1264510	1	0.955
NZ_AP022616_7	7.1\|4687410\|22\|NZ_AP022616\|CRISPRCasFinder	4687410-4687431	22	NZ_CP015881	Ensifer adhaerens strain Casida A plasmid pCasidaAA, complete sequence	610200-610221	1	0.955
NZ_AP022616_7	7.1\|4687410\|22\|NZ_AP022616\|CRISPRCasFinder	4687410-4687431	22	NZ_AP022571	Mycolicibacterium poriferae strain JCM 12603 plasmid pJCM12603, complete sequence	138869-138890	2	0.909
NZ_AP022616_7	7.1\|4687410\|22\|NZ_AP022616\|CRISPRCasFinder	4687410-4687431	22	NZ_CP021356	Rhodococcus sp. S2-17 plasmid pRB29, complete sequence	241430-241451	2	0.909
NZ_AP022616_7	7.1\|4687410\|22\|NZ_AP022616\|CRISPRCasFinder	4687410-4687431	22	NZ_CP013426	Burkholderia sp. MSMB0856 plasmid pMSMB0856, complete sequence	168217-168238	2	0.909
NZ_AP022616_7	7.1\|4687410\|22\|NZ_AP022616\|CRISPRCasFinder	4687410-4687431	22	MK967402	Mycobacterium phage NihilNomen, complete genome	24549-24570	2	0.909
NZ_AP022616_7	7.1\|4687410\|22\|NZ_AP022616\|CRISPRCasFinder	4687410-4687431	22	MK524521	Mycobacterium phage Schatzie, complete genome	23795-23816	2	0.909
NZ_AP022616_7	7.1\|4687410\|22\|NZ_AP022616\|CRISPRCasFinder	4687410-4687431	22	MN062701	Mycobacterium phage Dallas, complete genome	24019-24040	2	0.909
NZ_AP022616_7	7.1\|4687410\|22\|NZ_AP022616\|CRISPRCasFinder	4687410-4687431	22	MN183286	Mycobacteriophage Yeet, complete genome	23779-23800	2	0.909
NZ_AP022616_7	7.1\|4687410\|22\|NZ_AP022616\|CRISPRCasFinder	4687410-4687431	22	MK524504	Mycobacterium phage Hughesyang, complete genome	24666-24687	2	0.909
NZ_AP022616_7	7.7\|4687698\|22\|NZ_AP022616\|CRISPRCasFinder	4687698-4687719	22	NZ_CP019877	Komagataeibacter nataicola strain RZS01 plasmid pKNA02, complete sequence	18009-18030	2	0.909
NZ_AP022616_7	7.9\|4687788\|22\|NZ_AP022616\|CRISPRCasFinder	4687788-4687809	22	NZ_LR134459	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 17, complete sequence	82561-82582	2	0.909
NZ_AP022616_7	7.9\|4687788\|22\|NZ_AP022616\|CRISPRCasFinder	4687788-4687809	22	CP052267	Klebsiella pneumoniae strain E16KP0287 plasmid pE16K0287-2, complete sequence	2250-2271	2	0.909
NZ_AP022616_7	7.7\|4687698\|22\|NZ_AP022616\|CRISPRCasFinder	4687698-4687719	22	NC_004941	Corynebacterium glutamicum 227 plasmid pXZ608, complete sequence	2289-2310	3	0.864
NZ_AP022616_7	7.7\|4687698\|22\|NZ_AP022616\|CRISPRCasFinder	4687698-4687719	22	NZ_CP032695	Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence	1608661-1608682	3	0.864
NZ_AP022616_7	7.7\|4687698\|22\|NZ_AP022616\|CRISPRCasFinder	4687698-4687719	22	NC_048812	Gordonia phage Gibbin, complete genome	30380-30401	3	0.864
NZ_AP022616_7	7.11\|4687899\|22\|NZ_AP022616\|CRISPRCasFinder	4687899-4687920	22	NZ_CP024200	Thalassospira marina strain CSC3H3 plasmid pCSC3H3, complete sequence	106890-106911	3	0.864
NZ_AP022616_7	7.11\|4687899\|22\|NZ_AP022616\|CRISPRCasFinder	4687899-4687920	22	NZ_CP029389	Acinetobacter defluvii strain WCHA30 plasmid p1_010030, complete sequence	13023-13044	3	0.864
NZ_AP022616_4	4.1\|3892293\|27\|NZ_AP022616\|CRISPRCasFinder	3892293-3892319	27	NC_008741	Desulfovibrio vulgaris DP4 plasmid pDVUL01, complete sequence	28444-28470	5	0.815

1. spacer 7.9|4687788|22|NZ_AP022616|CRISPRCasFinder matches to NZ_LR134459 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 17, complete sequence) position: , mismatch: 0, identity: 1.0

cacgggcggtaccggcggtacc	CRISPR spacer
cacgggcggtaccggcggtacc	Protospacer
**********************

2. spacer 7.1|4687410|22|NZ_AP022616|CRISPRCasFinder matches to NZ_CP030263 (Ensifer adhaerens strain Corn53 plasmid AA, complete sequence) position: , mismatch: 1, identity: 0.955

tgcgggcgccgcgggtggcgcg	CRISPR spacer
tgcgggcgccgcggatggcgcg	Protospacer
**************.*******

3. spacer 7.1|4687410|22|NZ_AP022616|CRISPRCasFinder matches to NZ_CP016452 (Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence) position: , mismatch: 1, identity: 0.955

tgcgggcgccgcgggtggcgcg	CRISPR spacer
tgcgggcgccgcggatggcgcg	Protospacer
**************.*******

4. spacer 7.1|4687410|22|NZ_AP022616|CRISPRCasFinder matches to NZ_CP015881 (Ensifer adhaerens strain Casida A plasmid pCasidaAA, complete sequence) position: , mismatch: 1, identity: 0.955

tgcgggcgccgcgggtggcgcg	CRISPR spacer
tgcgggcgccgcggatggcgcg	Protospacer
**************.*******

5. spacer 7.1|4687410|22|NZ_AP022616|CRISPRCasFinder matches to NZ_AP022571 (Mycolicibacterium poriferae strain JCM 12603 plasmid pJCM12603, complete sequence) position: , mismatch: 2, identity: 0.909

tgcgggcgccgcgggtggcgcg	CRISPR spacer
ggcgggcgccgcaggtggcgcg	Protospacer
 ***********.*********

6. spacer 7.1|4687410|22|NZ_AP022616|CRISPRCasFinder matches to NZ_CP021356 (Rhodococcus sp. S2-17 plasmid pRB29, complete sequence) position: , mismatch: 2, identity: 0.909

tgcgggcgccgcgggtggcgcg	CRISPR spacer
agcgggctccgcgggtggcgcg	Protospacer
 ****** **************

7. spacer 7.1|4687410|22|NZ_AP022616|CRISPRCasFinder matches to NZ_CP013426 (Burkholderia sp. MSMB0856 plasmid pMSMB0856, complete sequence) position: , mismatch: 2, identity: 0.909

tgcgggcgccgcgggtggcgcg	CRISPR spacer
agcgggcgctgcgggtggcgcg	Protospacer
 ********.************

8. spacer 7.1|4687410|22|NZ_AP022616|CRISPRCasFinder matches to MK967402 (Mycobacterium phage NihilNomen, complete genome) position: , mismatch: 2, identity: 0.909

tgcgggcgccgcgggtggcgcg	CRISPR spacer
ttcgggcgccgcgggtggcgca	Protospacer
* *******************.

9. spacer 7.1|4687410|22|NZ_AP022616|CRISPRCasFinder matches to MK524521 (Mycobacterium phage Schatzie, complete genome) position: , mismatch: 2, identity: 0.909

tgcgggcgccgcgggtggcgcg	CRISPR spacer
ttcgggcgccgcgggtggcgca	Protospacer
* *******************.

10. spacer 7.1|4687410|22|NZ_AP022616|CRISPRCasFinder matches to MN062701 (Mycobacterium phage Dallas, complete genome) position: , mismatch: 2, identity: 0.909

tgcgggcgccgcgggtggcgcg	CRISPR spacer
ttcgggcgccgcgggtggcgca	Protospacer
* *******************.

11. spacer 7.1|4687410|22|NZ_AP022616|CRISPRCasFinder matches to MN183286 (Mycobacteriophage Yeet, complete genome) position: , mismatch: 2, identity: 0.909

tgcgggcgccgcgggtggcgcg	CRISPR spacer
ttcgggcgccgcgggtggcgca	Protospacer
* *******************.

12. spacer 7.1|4687410|22|NZ_AP022616|CRISPRCasFinder matches to MK524504 (Mycobacterium phage Hughesyang, complete genome) position: , mismatch: 2, identity: 0.909

tgcgggcgccgcgggtggcgcg	CRISPR spacer
ttcgggcgccgcgggtggcgca	Protospacer
* *******************.

13. spacer 7.7|4687698|22|NZ_AP022616|CRISPRCasFinder matches to NZ_CP019877 (Komagataeibacter nataicola strain RZS01 plasmid pKNA02, complete sequence) position: , mismatch: 2, identity: 0.909

caccggcggcacgggtggcaat	CRISPR spacer
taccggcggcacgggtggcaaa	Protospacer
.********************

14. spacer 7.9|4687788|22|NZ_AP022616|CRISPRCasFinder matches to NZ_LR134459 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 17, complete sequence) position: , mismatch: 2, identity: 0.909

cacgggcggtaccggcggtacc	CRISPR spacer
cacgggcggtaccggcggtgcg	Protospacer
*******************.*

15. spacer 7.9|4687788|22|NZ_AP022616|CRISPRCasFinder matches to CP052267 (Klebsiella pneumoniae strain E16KP0287 plasmid pE16K0287-2, complete sequence) position: , mismatch: 2, identity: 0.909

cacgggcggtaccggcggtacc	CRISPR spacer
cacgggcggtacgggcggtacg	Protospacer
************ ********

16. spacer 7.7|4687698|22|NZ_AP022616|CRISPRCasFinder matches to NC_004941 (Corynebacterium glutamicum 227 plasmid pXZ608, complete sequence) position: , mismatch: 3, identity: 0.864

caccggcggcacgggtggcaat	CRISPR spacer
gctcggcggcacgggtggcaat	Protospacer
  .*******************

17. spacer 7.7|4687698|22|NZ_AP022616|CRISPRCasFinder matches to NZ_CP032695 (Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence) position: , mismatch: 3, identity: 0.864

caccggcggcacgggtggcaat	CRISPR spacer
aaccggcggcacgggtggcacc	Protospacer
 ******************* .

18. spacer 7.7|4687698|22|NZ_AP022616|CRISPRCasFinder matches to NC_048812 (Gordonia phage Gibbin, complete genome) position: , mismatch: 3, identity: 0.864

caccggcggcacgggtggcaat	CRISPR spacer
gttcggcggcacgggtggcaat	Protospacer
  .*******************

19. spacer 7.11|4687899|22|NZ_AP022616|CRISPRCasFinder matches to NZ_CP024200 (Thalassospira marina strain CSC3H3 plasmid pCSC3H3, complete sequence) position: , mismatch: 3, identity: 0.864

tgcgggtggtaagggtggcacc	CRISPR spacer
gacgggtggtaagggtggcacg	Protospacer
 .*******************

20. spacer 7.11|4687899|22|NZ_AP022616|CRISPRCasFinder matches to NZ_CP029389 (Acinetobacter defluvii strain WCHA30 plasmid p1_010030, complete sequence) position: , mismatch: 3, identity: 0.864

tgcgggtggtaagggtggcacc	CRISPR spacer
tgcgggtggtaagggtggcgat	Protospacer
*******************. .

21. spacer 4.1|3892293|27|NZ_AP022616|CRISPRCasFinder matches to NC_008741 (Desulfovibrio vulgaris DP4 plasmid pDVUL01, complete sequence) position: , mismatch: 5, identity: 0.815

accgactcggccgtggggcgcggcgct	CRISPR spacer
atcttctcggccgtggggcgcggcgag	Protospacer
*.*  ********************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2102279 : 2145507

Streptomyces_phage(16.67%)

transposase,tRNA,protease

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_138248403.1\|2102279_2104949_-\|tRNA	valine--tRNA ligase	A0A1V0SK04	Klosneuvirus	1.2e-143	39.7
WP_138248402.1\|2105072_2105702_-	DUF937 domain-containing protein	NA	NA	NA	NA
WP_138248401.1\|2105801_2107061_-	enoyl-ACP reductase	NA	NA	NA	NA
WP_138248400.1\|2107070_2109050_-	S9 family peptidase	NA	NA	NA	NA
WP_138248399.1\|2109090_2109903_-	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_167526459.1\|2110012_2110513_-	transglycosylase family protein	A0A1J0GVU2	Streptomyces_phage	9.5e-26	64.6
WP_138248398.1\|2111200_2111779_-	molybdenum cofactor guanylyltransferase	NA	NA	NA	NA
WP_138248397.1\|2111789_2112872_-	2-oxoacid:ferredoxin oxidoreductase subunit beta	NA	NA	NA	NA
WP_138248396.1\|2112868_2114803_-	2-oxoacid:acceptor oxidoreductase subunit alpha	NA	NA	NA	NA
WP_020102196.1\|2115152_2115305_-	hypothetical protein	NA	NA	NA	NA
WP_138248395.1\|2115400_2116180_-	sulfite exporter TauE/SafE family protein	NA	NA	NA	NA
WP_138248394.1\|2116248_2116611_-	thioredoxin	A0A1J0GW78	Streptomyces_phage	2.4e-10	34.7
WP_138248393.1\|2116645_2117848_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_138248392.1\|2117868_2119248_-	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_138248391.1\|2119556_2121899_+	FdhF/YdeP family oxidoreductase	NA	NA	NA	NA
WP_138248390.1\|2121886_2122711_+	formate dehydrogenase accessory sulfurtransferase FdhD	NA	NA	NA	NA
WP_064859772.1\|2122763_2124044_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	6.6e-140	58.8
WP_138248389.1\|2124397_2125051_-	DUF3298 domain-containing protein	NA	NA	NA	NA
WP_064859774.1\|2125096_2126218_-	FHA domain-containing protein	NA	NA	NA	NA
WP_138248388.1\|2126237_2126729_-	hypothetical protein	NA	NA	NA	NA
WP_138248387.1\|2126725_2127940_-	hypothetical protein	NA	NA	NA	NA
WP_138248386.1\|2128139_2129483_+	hypothetical protein	NA	NA	NA	NA
WP_064859782.1\|2129539_2130175_-\|protease	ATP-dependent Clp protease proteolytic subunit	A0A248SJ97	Salicola_phage	2.0e-28	39.6
WP_167526403.1\|2130186_2130789_-\|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	1.5e-41	49.1
WP_138248385.1\|2130966_2132472_-	trigger factor	NA	NA	NA	NA
WP_138248588.1\|2133206_2134367_+	alkane 1-monooxygenase	NA	NA	NA	NA
WP_167526404.1\|2134363_2134771_-	DUF2628 domain-containing protein	NA	NA	NA	NA
WP_138248384.1\|2134824_2135385_-	hypothetical protein	NA	NA	NA	NA
WP_138248383.1\|2135562_2136198_-	NUDIX hydrolase	NA	NA	NA	NA
WP_138248382.1\|2136190_2137723_-	nicotinate phosphoribosyltransferase	A0A160DEX8	Gordonia_phage	5.7e-146	59.5
WP_163692700.1\|2137737_2138589_-	ribose-phosphate pyrophosphokinase	A0A291I9X9	Mycobacterium_phage	5.8e-31	40.1
WP_138248380.1\|2138661_2139516_+	DUF1542 domain-containing protein	NA	NA	NA	NA
WP_163692701.1\|2139562_2139958_+\|transposase	transposase	A0A0N9SHJ4	Paenibacillus_phage	1.2e-15	40.9
WP_163692703.1\|2139986_2140325_+\|transposase	transposase	NA	NA	NA	NA
WP_053855802.1\|2140315_2141653_-\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	8.2e-32	36.7
WP_138248377.1\|2141949_2142744_-	Fpg/Nei family DNA glycosylase	A0A1V0CNR6	Kaumoebavirus	3.2e-07	24.1
WP_138248376.1\|2142759_2143239_-	ribose-5-phosphate isomerase	NA	NA	NA	NA
WP_138248375.1\|2143284_2145507_-	protein kinase	A0A2H4UVE2	Bodo_saltans_virus	7.3e-17	28.2

DBSCAN-SWA_2

3770251 : 3845581

Mycobacterium_phage(23.08%)

integrase,transposase,tRNA

attL 3802809:3802828|attR 3824538:3824557

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_138251208.1\|3770251_3771799_-\|transposase	IS1182 family transposase	NA	NA	NA	NA
WP_138251321.1\|3772031_3772505_-	AAA family ATPase	NA	NA	NA	NA
WP_061006394.1\|3772616_3773810_-	N-acetylmuramoyl-L-alanine amidase	NA	NA	NA	NA
WP_133428075.1\|3773968_3774301_-	thioredoxin	A0A1J0GW78	Streptomyces_phage	7.0e-25	54.9
WP_061006396.1\|3774341_3775280_-	thioredoxin-disulfide reductase	A0A2I2L5E1	Orpheovirus	3.6e-74	49.8
WP_138251320.1\|3775402_3776167_-	hypothetical protein	NA	NA	NA	NA
WP_138251319.1\|3776212_3776764_-	RNA polymerase sigma factor SigM	NA	NA	NA	NA
WP_138251327.1\|3776860_3780139_-	murein biosynthesis integral membrane protein MurJ	NA	NA	NA	NA
WP_138251328.1\|3780234_3782622_-	hypothetical protein	NA	NA	NA	NA
WP_138251318.1\|3782633_3783419_-	NUDIX hydrolase	NA	NA	NA	NA
WP_138251326.1\|3783593_3785045_+\|tRNA	CCA tRNA nucleotidyltransferase	A0A249XS88	Mycobacterium_phage	4.0e-64	38.1
WP_061006400.1\|3785063_3785546_+	hypothetical protein	NA	NA	NA	NA
WP_138251317.1\|3785542_3786325_-	TIGR03084 family protein	NA	NA	NA	NA
WP_131808642.1\|3786984_3787542_+	hypothetical protein	NA	NA	NA	NA
WP_138251316.1\|3787538_3788810_-	MFS transporter	NA	NA	NA	NA
WP_138251315.1\|3788937_3789549_+	YqgE/AlgH family protein	NA	NA	NA	NA
WP_133428083.1\|3789559_3789916_-	hypothetical protein	NA	NA	NA	NA
WP_138251314.1\|3789965_3790973_-	hypothetical protein	NA	NA	NA	NA
WP_138251325.1\|3791198_3794051_+\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	1.9e-211	45.3
WP_138251313.1\|3794114_3794780_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_061006195.1\|3794834_3796175_+	hypothetical protein	NA	NA	NA	NA
WP_061006194.1\|3796185_3796650_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_138251312.1\|3796690_3797428_-	amino acid ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	4.4e-19	32.2
WP_163692860.1\|3797424_3799185_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_138251311.1\|3799263_3800046_-	LLM class F420-dependent oxidoreductase	NA	NA	NA	NA
WP_138251310.1\|3800055_3800958_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_138251309.1\|3800991_3802563_-	alkyl hydroperoxide reductase subunit F	G3MA85	Bacillus_virus	6.9e-38	33.9
WP_061006190.1\|3802692_3803256_-	alkyl hydroperoxide reductase subunit C	NA	NA	NA	NA
3802809:3802828	attL	NA	NA	NA	NA
WP_138251308.1\|3803441_3804530_-	inositol-3-phosphate synthase	A0A0H4IPK5	Stenotrophomonas_phage	5.2e-69	40.3
WP_064857478.1\|3804584_3805157_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_082934498.1\|3805323_3806178_-	DUF1707 domain-containing protein	NA	NA	NA	NA
WP_020099850.1\|3806322_3806754_+	DUF5318 domain-containing protein	NA	NA	NA	NA
WP_163692862.1\|3806758_3809227_+	penicillin-binding protein	NA	NA	NA	NA
WP_138251306.1\|3809223_3810873_+	DUF2029 domain-containing protein	NA	NA	NA	NA
WP_138251305.1\|3810914_3811379_+	SRPBCC family protein	NA	NA	NA	NA
WP_138251304.1\|3811570_3812161_-	hypothetical protein	NA	NA	NA	NA
WP_138251303.1\|3812190_3812838_-	hypothetical protein	NA	NA	NA	NA
WP_138251302.1\|3812991_3813627_-	hypothetical protein	NA	NA	NA	NA
WP_020099843.1\|3813820_3814111_+	30S ribosomal protein S6	NA	NA	NA	NA
WP_138251301.1\|3814192_3814702_+	single-stranded DNA-binding protein	A0A2H4JEL4	uncultured_Caudovirales_phage	3.8e-54	87.7
WP_020099841.1\|3814749_3815004_+	30S ribosomal protein S18	NA	NA	NA	NA
WP_138251300.1\|3815019_3815475_+	50S ribosomal protein L9	NA	NA	NA	NA
WP_138251323.1\|3816015_3819045_+	replicative DNA helicase	A0A1P8VVQ6	Streptococcus_phage	2.3e-58	29.4
WP_138251322.1\|3819290_3819965_+\|transposase	TnsA-like heteromeric transposase endonuclease subunit	NA	NA	NA	NA
WP_138251299.1\|3819961_3822115_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_138251298.1\|3822111_3823236_+	AAA family ATPase	NA	NA	NA	NA
WP_138251297.1\|3823242_3825579_+	TniQ family protein	NA	NA	NA	NA
3824538:3824557	attR	NA	NA	NA	NA
WP_138251296.1\|3825611_3828281_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_061003426.1\|3828388_3829795_-\|transposase	IS1380 family transposase	A0A222ZN33	Mycobacterium_phage	1.4e-79	41.7
WP_138251295.1\|3830391_3830619_+	hypothetical protein	NA	NA	NA	NA
WP_138251294.1\|3830682_3831396_-	XRE family transcriptional regulator	NA	NA	NA	NA
WP_138251293.1\|3831644_3831851_-	hypothetical protein	NA	NA	NA	NA
WP_163692864.1\|3832048_3832567_+	NYN domain-containing protein	NA	NA	NA	NA
WP_138251291.1\|3832566_3834666_+	N-6 DNA methylase	NA	NA	NA	NA
WP_138251290.1\|3834742_3836479_+	SAM-dependent DNA methyltransferase	A0A220A2U4	Liberibacter_phage	1.3e-32	33.2
WP_138251289.1\|3836475_3837777_+	restriction endonuclease subunit S	NA	NA	NA	NA
WP_138251288.1\|3837780_3840936_+	type I restriction endonuclease subunit R	NA	NA	NA	NA
WP_163692866.1\|3842510_3843824_+\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	2.3e-228	91.3
WP_138251361.1\|3843916_3845074_-	hypothetical protein	NA	NA	NA	NA
WP_163692868.1\|3845206_3845581_+\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	2.4e-18	49.1

DBSCAN-SWA_3

5290493 : 5324182

Mycobacterium_phage(40.0%)

integrase,transposase

attL 5312632:5312691|attR 5324156:5325637

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_064860310.1\|5290493_5291468_-\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	2.7e-56	49.4
WP_138251341.1\|5294165_5295401_+\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	3.1e-110	53.4
WP_138251340.1\|5295845_5296658_+	ABC transporter permease	NA	NA	NA	NA
WP_138251339.1\|5296654_5297509_+	ABC transporter permease	NA	NA	NA	NA
WP_138251338.1\|5297474_5298869_+	MCE family protein	NA	NA	NA	NA
WP_138251337.1\|5298911_5299940_+	virulence factor Mce family protein	NA	NA	NA	NA
WP_138251336.1\|5299936_5301292_+	MCE family protein	NA	NA	NA	NA
WP_138251335.1\|5301288_5302617_+	MCE family protein	NA	NA	NA	NA
WP_138251334.1\|5302613_5303756_+	virulence factor Mce family protein	NA	NA	NA	NA
WP_138251333.1\|5303759_5305223_+	MCE family protein	NA	NA	NA	NA
WP_138251332.1\|5305212_5305827_+	hypothetical protein	NA	NA	NA	NA
WP_138251331.1\|5305823_5306486_+	hypothetical protein	NA	NA	NA	NA
WP_138251330.1\|5306485_5306881_+	DUF732 domain-containing protein	NA	NA	NA	NA
WP_167526436.1\|5306881_5307367_+	CAP domain-containing protein	NA	NA	NA	NA
WP_138251329.1\|5307558_5308458_+	esterase family protein	A0A2I6AZH7	Macacine_betaherpesvirus	3.5e-47	39.4
WP_036429724.1\|5310137_5311229_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_138251366.1\|5311599_5311806_+	hypothetical protein	NA	NA	NA	NA
WP_138251365.1\|5311796_5311991_+	mechanosensitive ion channel	NA	NA	NA	NA
WP_138251364.1\|5312000_5312405_+	hypothetical protein	NA	NA	NA	NA
5312632:5312691	attL	NA	NA	NA	NA
WP_067990476.1\|5312664_5313978_-\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	2.3e-228	91.3
WP_138251344.1\|5314118_5315102_-	hypothetical protein	NA	NA	NA	NA
WP_138251345.1\|5315181_5316819_-\|integrase	integrase	NA	NA	NA	NA
WP_138251346.1\|5316957_5318088_-	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
WP_163693016.1\|5318084_5318447_-	hypothetical protein	NA	NA	NA	NA
WP_138251348.1\|5318542_5319070_+	hypothetical protein	NA	NA	NA	NA
WP_138251349.1\|5319554_5320148_+	hypothetical protein	NA	NA	NA	NA
WP_138251350.1\|5320140_5321550_+	hypothetical protein	NA	NA	NA	NA
WP_163693018.1\|5322046_5322433_-	ankyrin repeat domain-containing protein	NA	NA	NA	NA
WP_067990476.1\|5322868_5324182_+\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	2.3e-228	91.3
5324156:5325637	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_AP022616

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection