CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_AP022585	Mycobacterium marseillense strain JCM 17324 plasmid pJCM17324, complete sequence	0 crisprs	NA	0	0	0	0
NZ_AP022584	Mycobacterium marseillense strain JCM 17324	4 crisprs	csa3,DEDDh,cas4,WYL,cas3,DinG	1	2	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_AP022584_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022584_1

838222-838341

Orphan

Consensus_repeat	Method
GTCGCATGCCAGCGGCTGTGGGCCGACGCCGAGCGGTCGGCAGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022584_1

>merge|NZ_AP022584|1|838222-838341|CRISPRCasFinder
GTCGCATGCCAGCGGCTGTGGGCCGACGCCGAGCGGTCGGCAGACGTTGGCGGTTGGATCCCACCACTGGCCCGGGTCGCATGCCAGCGGTTGTGGGCCGACGCCGAGCGGTCGGCAGAC

>NZ_AP022584|1|1|838222-838341|CRISPRCasFinder
GTCGCATGCCAGCGGCTGTGGGCCGACGCCGAGCGGTCGGCAGAC	GTTGGCGGTTGGATCCCACCACTGGCCCGG
GTCGCATGCCAGCGGTTGTGGGCCGACGCCGAGCGGTCGGCAGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022584.1\|WP_036459101.1\|839256_839613_-\|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin	unknown	unknown	gnl\|CDD\|273688
NZ_AP022584.1\|WP_067169755.1\|844763_845999_-\|osmoprotectant-NAGGN-system-M42-family-peptidase	unknown	unknown	gnl\|CDD\|132150
NZ_AP022584.1\|WP_036459011.1\|843264_843948_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378566
NZ_AP022584.1\|WP_165605061.1\|842533_842992_-\|lipocalin-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|372819
NZ_AP022584.1\|WP_083017168.1\|827996_828668_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022584.1\|WP_067169766.1\|841707_842469_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235816
NZ_AP022584.1\|WP_082991412.1\|833948_834377_-\|cellulose-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|366161
NZ_AP022584.1\|WP_036459006.1\|840399_840843_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|378915
NZ_AP022584.1\|WP_083017174.1\|831653_832523_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_AP022584.1\|WP_095578199.1\|836376_837027_+\|cutinase-family-protein	unknown	unknown	gnl\|CDD\|366455
NZ_AP022584.1\|WP_083017178.1\|837161_837986_-\|PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274712
NZ_AP022584.1\|WP_067169768.1\|841062_841677_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022584.1\|WP_067169758.1\|843999_844767_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NZ_AP022584.1\|WP_083017170.1\|830068_830677_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022584.1\|WP_083017172.1\|831122_831605_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176854
NZ_AP022584.1\|WP_067169788.1\|829161_829980_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_AP022584.1\|WP_083017176.1\|835476_836058_-\|dihydrofolate-reductase-family-protein	unknown	unknown	gnl\|CDD\|334719
NZ_AP022584.1\|WP_083017258.1\|834508_835294_-\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|226480
NZ_AP022584.1\|WP_036459005.1\|839803_840370_+\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|223619
NZ_AP022584.1\|WP_036459004.1\|838589_839243_-\|zeta-toxin-family-protein	unknown	unknown	gnl\|CDD\|226648

Protein	Function_ID	Function_description	E-value
NZ_AP022584.1\|WP_036459101.1\|839256_839613_-\|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin	gnl\|CDD\|273688	TIGR01552, Hypothetical_protein_Rv3357/MT3465/Mb3392., prevent-host-death family protein. This model recognizes a region of about 55 amino acids toward the N-terminal end of bacterial proteins of about 85 amino acids in length. The best-characterized member is prevent-host-death (phd) of bacteriophage P1, the antidote partner of death-on-curing (doc) (TIGR01550) in an addiction module. Addiction modules prevent plasmid curing by killing the host cell as the longer-lived killing protein persists while the gene for the shorter-lived antidote is lost. Note, however, that relatively few members of this family appear to be plasmid or phage-encoded. Also, there is little overlap, except for phage P1 itself, of species with this family and with the doc family. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other].	2.21476e-07
NZ_AP022584.1\|WP_067169755.1\|844763_845999_-\|osmoprotectant-NAGGN-system-M42-family-peptidase	gnl\|CDD\|132150	TIGR03106, trio_M42_hydro, hydrolase, peptidase M42 family. This model describes a subfamily of MEROPS peptidase family M42, a glutamyl aminopeptidase family that also includes the cellulase CelM from Clostridium thermocellum and deblocking aminopeptidases that can remove acylated amino acids. Members of this family occur in a three gene cassette with an amidotransferase (TIGR03104)in the asparagine synthase (glutamine-hydrolyzing) family, and a probable acetyltransferase (TIGR03103) in the GNAT family.	0
NZ_AP022584.1\|WP_036459011.1\|843264_843948_+\|hypothetical-protein	gnl\|CDD\|378566	pfam11139, SfLAP, Sap, sulfolipid-1-addressing protein. SAP is a transmembrane transport protein with six predicted transmembrane helices, with a hydrophilic domain between helices 3 and 4. This hyrodphobic region is highly variable among identified Gap-like (GPL, peptidoglycolipid, addressing protein) proteins and may be involved in substrate recognition. SAP also belongs to the LysE protein superfamily (pfam01810), whose members have been implicated in small molecule transport in bacteria. Other Gap proteins export metabolites across the cell membrane so it is possible that Sap specifically may be involved in transport of sulfolipid-1 across the membrane.	0.00153494
NZ_AP022584.1\|WP_165605061.1\|842533_842992_-\|lipocalin-like-domain-containing-protein	gnl\|CDD\|372819	pfam13924, Lipocalin_5, Lipocalin-like domain. This family includes domains distantly related to lipocalins. However, they do contain the important GXW motif in the first strand. The protein in this family include aln5, which is involved in biosynthesis of alnumycin. The family also includes the ZFK protein from Trypanosoma brucei which is a protein kinase. This domain is at the C-terminus of that protein. The domain is also found as the C-terminal domain in StiJ a protein involved in producing stigmatellin. This domain has been assumed to catalyze a final cyclisation reaction.	9.78901e-43
NZ_AP022584.1\|WP_067169766.1\|841707_842469_-\|SDR-family-oxidoreductase	gnl\|CDD\|235816	PRK06500, PRK06500, SDR family oxidoreductase.	1.07821e-73
NZ_AP022584.1\|WP_082991412.1\|833948_834377_-\|cellulose-binding-domain-containing-protein	gnl\|CDD\|366161	pfam00553, CBM_2, Cellulose binding domain. Two tryptophan residues are involved in cellulose binding. Cellulose binding domain found in bacteria.	2.99565e-33
NZ_AP022584.1\|WP_036459006.1\|840399_840843_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	1.17993e-09
NZ_AP022584.1\|WP_083017174.1\|831653_832523_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	4.45737e-23
NZ_AP022584.1\|WP_095578199.1\|836376_837027_+\|cutinase-family-protein	gnl\|CDD\|366455	pfam01083, Cutinase, Cutinase.	1.23165e-45
NZ_AP022584.1\|WP_083017178.1\|837161_837986_-\|PPOX-class-F420-dependent-oxidoreductase	gnl\|CDD\|274712	TIGR03666, Rv2061_F420, PPOX class probable F420-dependent enzyme, Rv2061 family. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. A variant of the Partial Phylogenetic Profiling algorithm, SIMBAL, shows that this protein likely binds F420 in a cleft similar to that in which the homologous enzyme pyridoxamine phosphate oxidase (PPOX) binds FMN. [Unknown function, Enzymes of unknown specificity].	2.63033e-30
NZ_AP022584.1\|WP_067169758.1\|843999_844767_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	3.70519e-19
NZ_AP022584.1\|WP_083017172.1\|831122_831605_+\|SRPBCC-family-protein	gnl\|CDD\|176854	cd07812, SRPBCC, START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket; they bind diverse ligands. Included in this superfamily are the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, and the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), as well as the SRPBCC domains of phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of this superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	2.06057e-16
NZ_AP022584.1\|WP_067169788.1\|829161_829980_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.0235e-39
NZ_AP022584.1\|WP_083017176.1\|835476_836058_-\|dihydrofolate-reductase-family-protein	gnl\|CDD\|334719	pfam01872, RibD_C, RibD C-terminal domain. The function of this domain is not known, but it is thought to be involved in riboflavin biosynthesis. This domain is found in the C-terminus of RibD/RibG, in combination with pfam00383, as well as in isolation in some archaebacterial proteins. This family appears to be related to pfam00186.	4.04547e-11
NZ_AP022584.1\|WP_036459005.1\|839803_840370_+\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|223619	COG0545, FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones].	3.27578e-20
NZ_AP022584.1\|WP_083017258.1\|834508_835294_-\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|226480	COG3971, COG3971, 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism].	5.0608e-105
NZ_AP022584.1\|WP_036459004.1\|838589_839243_-\|zeta-toxin-family-protein	gnl\|CDD\|226648	COG4185, COG4185, Uncharacterized protein conserved in bacteria [Function unknown].	2.82704e-35

>NZ_AP022584.1|WP_083017178.1|837161_837986_-|PPOX-class-F420-dependent-oxidoreductase
MMNRLSTPARIFVVTTAAVVGIVTAGIGIWCLIDPNSFAGSVGFEAHRHFLHDVGAFQLSLGVTVLLALIWADALATALAGFIVANTVHTVNHVIDLDVGGSPEQAWVLGAVSVVLVVAFALRLRQLGYVLGAIGTATNSALAPFVRQKTISLTTFRKDGTPGSSPVSIVVEGDRAYVRSFERAVKVRRIRRNPNVEFGAATASGKPTGSTLSGTVRLLDGAEYSKAGYLLRQKYPLLHGVLVPLAHRAMRSKYGRTIHAELIPCSGPLATEPE
>NZ_AP022584.1|WP_095578199.1|836376_837027_+|cutinase-family-protein
MGTMPAPPASAEPCPDVDVVFARGTGEPPGVGGVGQAFVDALRSRVGGKSVGVYPVNYEASGDFNGGIEFARTFVDGIRDAGSHVESTASNCPNTKVVLGGYSQGAAVAGFVTSPVVPKEVPQEFVSYVPQPLPQSVANHVAAVVLFGTPSNEFLRGAGAPPITIGPLYAPKTIQLCASDDTICNGAPPGPPGIAHTLYAANGMVDQGADFAASHL
>NZ_AP022584.1|WP_083017176.1|835476_836058_-|dihydrofolate-reductase-family-protein
MTTTYTFDIFSSLDGFGGVSGGDWGGYWGKQGPELLDHRLALYGKKQRMVLGANTYRLFAQMLAQSTEDSEVHDPWVTRMRHLPATVVSSTLDGPLDWPAATVACGDAVDIVARLKEESEVPLRSHGSLSMNRALMAVGLVDRVQVTIFPVITGQTGDDRIFDGAADFDLELIETRTLDRNIQELVYRPTLHF
>NZ_AP022584.1|WP_083017258.1|834508_835294_-|fumarylacetoacetate-hydrolase-family-protein
MLSVAIRDELAADLAHAERSRAPIAPLIVAYPDIDVVDAYEIQLINIRQRVAEGARVVGHKVGLSSLAMQQMMAVDEPDYGHLLDEMQVFEDVPVEAAHYLYPRVEVEVGFILSEDLPGAGCTEDDVVAATAALAPSIELIDTRITDWKIALCDTIADNASSAGFVLGEARVPPRDLDAKAIDAVLTRNGEVVAEGRGDAVLGNPVTAVAWLARKVESFGVRLRKGDIVLPGSCTRAIDARPGDEFVAEFSGLGSVRLSFE
>NZ_AP022584.1|WP_082991412.1|833948_834377_-|cellulose-binding-domain-containing-protein
MARLNDYVKRWRTALHVAVSALMVAIIGLAISPVAHAAAATATLSVAHTWQTGFIANFTVTNSSMAPLSDWKLEFDMPAGQSVSHTWNSTITQSGTHYVLTPANWNRVIAPGGSATGGLRGVLSGTYSPPSNCVLNRQYPCT
>NZ_AP022584.1|WP_083017174.1|831653_832523_-|alpha/beta-hydrolase
MNICTLEDHRRYASTPSGPISYLDVGSGRPAVFIHGILANSLLWRHVIAAMAGDRRRCIVVDLPGHGHTPPAPANADVTLTGLARRVVELCEHLGLDRFDLVGNDTGGAVAQIVAAHVGRRLSTFTLTNCDTEGNTPPTLFKPVAVAARLGLLARIGPRVAASRRLKLSGLTAGCPHPGRLPAEVVDAYYDPVFGTPESSRAFARLVTAISSTDLAAVRSELGALMVPTLIVWGTGDVFFRLKWARRLADLIPGTVGITTVHGARMHFPDYRADEFIPALQQHWAQHSS
>NZ_AP022584.1|WP_083017172.1|831122_831605_+|SRPBCC-family-protein
MHGFATIDMNASPQAVWSLISDVTQIGRFSPETFEAQWLNGAVGPAVGAKFRGHVKRNEKGPTYWTACTVTECDPGRVFAFAVRSRPLGLPIAPSNTVQVTWRFSLSPTSGGGTSVTESFELRDIPAMRLYWRALGWLRGPRLMEDMKRTLRAIKDAVEQ
>NZ_AP022584.1|WP_083017170.1|830068_830677_-|hypothetical-protein
MRTIAYRHAAFVGLAAVALFAAGCSNGKSVDASSPPQTSVNASSVSNTPAQPPEVKLRGERDVEVTLTGPIAAKYSSATEEQRQALGKPLTGDRNAGKRDSGLVFQQFQGGVSTAKNDAAGTPAYITLGKIRDAWNIPRAPDGTPAVTGSNGSAGPLGFPTSDVNAVGDLQVSTFEHGKIEYNPTTDQVNVTVNGKVVPSGL
>NZ_AP022584.1|WP_067169788.1|829161_829980_+|alpha/beta-hydrolase
MPAITTSDGAEIFYKDWGSGQPIVFSHGWPLTADDWDAQMMFFLHHGYRVIAHDRRGHGRSEQTGNGNDMEHWVADLASLTEQLDLHDAIHIGHSTGGAEVACYVARHQERVAKAVLVSSPTPSMAQTENNPGGQPQEWFEAVQAGVLGNRSEFFRAVPEGPFYGFNRSGVEPSEAVIANWWRQGMSGSAHAHYETVFSWLHDYTEDLRAITVPVLVMHGDDDQIVPFASSVPRAVDLLQNGALKTYAGYPHGMLTTHADVLNPDLLAFIAP
>NZ_AP022584.1|WP_083017168.1|827996_828668_-|hypothetical-protein
MFQPELVVVNFRVKVKQPPPENWGLIVGDILTNLRAALDHALFGHASARQTLTAAQERALQYPLIAKASEWAGAQAKLAPLTEPAVLQVIEDSQPFKAQKPDWHSFALLNGLVNRDKHRQVRVVSYSNEAFDITSTTGDVERVDNKPREMTDGALVASVTLRRPLRKPGDSPADVSVPLNVEFGYTENIELPTVAEQKSVTVVMPILVDHVIETLDNLKAAGA
>NZ_AP022584.1|WP_036459004.1|838589_839243_-|zeta-toxin-family-protein
MARTKTQPAQIHVLAGVNGAGKSSVVGATIRDKGGQYYNPDEAARDIVAANPGLGQAEANAAAWEQGRRLLQRAIDEGLDFTFETTLGGNTMPALLAEAAKRGLQVHVFYVGLDSADTCIERVRQRVRAGGHDISDADIRRRYRHSLINLVKLLPVLTGLRVYDNSASADPAIGQAPRPVLVLHMDRGRIVGPPDLSSTPAWAKPVVAAALDLARRS
>NZ_AP022584.1|WP_036459101.1|839256_839613_-|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin
MSTVSFRNRDGKLVDVPSVTASRLKNEFGTVFDEAAVSGAVVITKHNTPRAVLLSYAEFEALAATAAPALDELSERFDELLATMQRSKAKAGVAAAFDATPEELGAAAVKAARTAPSR
>NZ_AP022584.1|WP_036459005.1|839803_840370_+|FKBP-type-peptidyl-prolyl-cis-trans-isomerase
MTAVNSFRMYSSVALAACAAATVLLLAGSGTANAAGSCPTAAPQNGGAPDWTLAGNTGSVAVTGSTDTTAPRVTVTAPFAVTQTQVHTLHAGDGPVVSSTAKVSVCYMGVNGRDGSVFDSSYERGAAVDFPLTGVVPGFQKAIAGQKVGSTVAVAMVPADGYPQGQPSAGIRPGDTLVFAIKILSASG
>NZ_AP022584.1|WP_036459006.1|840399_840843_-|nuclear-transport-factor-2-family-protein
MTKSVATKNDNEKIVVDFIHAAYGESMDIDAMTALMADDFAWQLHVPLSPVVRGRNAARAELEKHNTLSTGMVEGSEIRTIVSDGDTVIVERVDVNSMNGVTVTFYVTAIFEVRDGAITHWREYWDTAHVAQQLGIDPALMFAPLGN
>NZ_AP022584.1|WP_067169768.1|841062_841677_+|hypothetical-protein
MAEIFNRTVSRRAFVRGVGLSVPVVGIVAFAAPQALASPPGCDDPSGMVDNCAVQLPEEFTSTSFSTTAIAGGTNYSILFSTKISSGPLVPKGATGYRIRSTSVAGQKQDGTPFSLKPAIGEAGPRVLGARSASSLGFSLDVVWSGGQLVRSFDYTYDVAFLNGLTEIQTCTYMTTMTLADNGLTLGGVGSVTFSPPRLTVCAG
>NZ_AP022584.1|WP_067169766.1|841707_842469_-|SDR-family-oxidoreductase
MGLLDHKTAVITGANSGIGLAIAERFLAEGAERVFITGRRQAELDTAARELGSRAIAVAGDVGTPKDLDRLYARVASAGQGLDIVMANAGSTRVAPLGEITDDDLDALLTTNVKGVVYTVQKALPLLNDGASVILTGSTTADRGRAGLSIYAATKAAVRSLARAWANELAGRNIRVNVIVAGSTATPGSDTLAAQTDPDASIDEFRAGRIATIPLGRFADPVEIANAAVFLASDLSSFTTGSTLTADGGFNQV
>NZ_AP022584.1|WP_165605061.1|842533_842992_-|lipocalin-like-domain-containing-protein
MTPQELREYLVGAWALESYQSSDPDGSNPRYPLGPDARGIIMYTADGYMSAQIMRADRAPFTRGDLQIADASELVAAAKGYLAYAGPYSVLDNGVIAHHVDVSLLPNWVGGTQYRAAKAGDGRLELSPAEPVVIKGRPRHGRLLWQRAKNPE
>NZ_AP022584.1|WP_036459011.1|843264_843948_+|hypothetical-protein
MAALILALAGLAFLDSLNVLNVGVVSAVIFDSRLGRRSPIPGALSFVAGVFAVTTTFGLCTVLGISFITQALDFHITPAIRFRGELLLGIVLIGLAYFPLTAQSSAPGWAMAAMRKRPWLLGFLGLAVGSGQAPTAVPYLTGLAMLAALHPRPPLWPLIIIAYCAIAITPPLAILALSMRRTVRAMRIQRGLVRVLTRYGPMSVRLLFLVFGVGLIADAFVNHSALW
>NZ_AP022584.1|WP_067169758.1|843999_844767_+|class-I-SAM-dependent-methyltransferase
MTDRQARAMSFGSIAEDYDSLRPQAPQQAVDWLMPSGCEVAVDLGAGTGLFTRTLVGRAAHVIAVEPDARMRAVLADRSPGVRVLEGSGESIPLPDRAADAVFVSAAWHWMDPERAVPEIGRVLRDGGRFGLIWTSRDRDVDWIRDLDLLPGDDATEADAPARFRRLHEDVALPDPQIFHHVAREAFRFVRTMRVDDVVAMLGTYSRIITASPDDRERRLANARAALRERFGAADAIDVPMQSRCWRADRMARGS
>NZ_AP022584.1|WP_067169755.1|844763_845999_-|osmoprotectant-NAGGN-system-M42-family-peptidase
MGQTAAMAEADRTWMIDTLLALLQTPSPSGRTDAVMQVIGDILDDFGVPFTLTRRGALTAELPGESATTDRALVVHSDTIGCMIRNLKDNGRLELVPVGTFSARFAAGARVRIFIDDPDEFITGTVMPLKSSGHAFGDEIDTQPTDWEHVEVRIDRRVSTRDDLVRLGLQVGDFVALITSPELTADGFIVSRHLDGKAGVAIALALAKNFSENKVVLPHRTTILVTITEEVGHGASHGLPADVAELVSVDNAVCAPGQHSLEDGVTIPMADMHGPFDYHLTRKLCRLAQEQGIPFARDIFRYYRSDAAAAIEAGANTRAALVGFGLDGSHGWERTHIDSLEAAYNLLHCWLQTPLTFAKWDAKPTGRLRDFPSSKQPAPSERWVPLSRGDYESPGEASPGTPWPPSEGPQA

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Crispr_ID: NZ_AP022584_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022584_2

1458118-1458257

Orphan

Consensus_repeat	Method
CCGCATCGGCCTCCGGCTCGCCG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_AP022584_2

>merge|NZ_AP022584|2|1458118-1458257|CRISPRCasFinder
CCGCATCGGCCTCCGGCTCGCCGAGCTCGAGCTCCTCGGCCTCGGATTCCTCGGCTTCGGCCTCGTCGGCCACCGCCTCGGCCTCCGGCTCGCCGGACTCATCGACGACCGCCTGTTCGTCTTCGGCTTGCGGCTCTTCG

>NZ_AP022584|2|2|1458118-1458257|CRISPRCasFinder
CCGCATCGGCCTCCGGCTCGCCG	AGCTCGAGCTCCTCGGCCTCGGATTCCTCGGCTTCGG
CCTCGTCGGCCACCGCCTCGGCC	TCCGGCTCGCCGGACTCATCGACGACCGCCTGTT
CGTCTTCGGCTTGCGGCTCTTCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022584.1\|WP_067172866.1\|1451200_1452877_+\|thiol-reductant-ABC-exporter-subunit-CydC	unknown	unknown	gnl\|CDD\|274331
NZ_AP022584.1\|WP_083016234.1\|1449600_1451214_+\|thiol-reductant-ABC-exporter-subunit-CydD	unknown	unknown	gnl\|CDD\|227321
NZ_AP022584.1\|WP_095578227.1\|1454925_1455771_-\|acyl-CoA-thioesterase-II	unknown	unknown	gnl\|CDD\|224857
NZ_AP022584.1\|WP_067172895.1\|1461589_1462408_-\|indole-3-glycerol-phosphate-synthase-TrpC	unknown	unknown	gnl\|CDD\|234710
NZ_AP022584.1\|WP_067172897.1\|1463199_1464738_-\|anthranilate-synthase-component-I	unknown	unknown	gnl\|CDD\|184152
NZ_AP022584.1\|WP_008257742.1\|1455902_1457321_-\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|180487
NZ_AP022584.1\|WP_067172901.1\|1466483_1466831_-\|phosphoribosyl-AMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234598
NZ_AP022584.1\|WP_067172888.1\|1459443_1460259_-\|tryptophan-synthase-subunit-alpha	unknown	unknown	gnl\|CDD\|237285
NZ_AP022584.1\|WP_083016101.1\|1446983_1448456_+\|cytochrome-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|376587
NZ_AP022584.1\|WP_067172873.1\|1453384_1454782_-\|DUF2156-domain-containing-protein	unknown	unknown	gnl\|CDD\|225451
NZ_AP022584.1\|WP_139799098.1\|1446309_1446897_+\|DUF308-domain-containing-protein	unknown	unknown	gnl\|CDD\|225786
NZ_AP022584.1\|WP_083016115.1\|1464832_1465291_+\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239315
NZ_AP022584.1\|WP_067172904.1\|1466827_1467616_-\|imidazole-glycerol-phosphate-synthase-subunit-HisF	unknown	unknown	gnl\|CDD\|234996
NZ_AP022584.1\|WP_083016118.1\|1465297_1466407_-\|calcium:proton-antiporter	unknown	unknown	gnl\|CDD\|223464
NZ_AP022584.1\|WP_083016112.1\|1460255_1461515_-\|tryptophan-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|235288
NZ_AP022584.1\|WP_083016105.1\|1448497_1449538_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|376764
NZ_AP022584.1\|WP_067172869.1\|1452894_1453206_-\|UsfY-protein	unknown	unknown	unknown
NZ_AP022584.1\|WP_067172907.1\|1467617_1468418_-\|inositol-monophosphatase-family-protein	unknown	unknown	gnl\|CDD\|223559
NZ_AP022584.1\|WP_067172880.1\|1457386_1457848_-\|DUF2752-domain-containing-protein	unknown	unknown	gnl\|CDD\|378499
NZ_AP022584.1\|WP_067172970.1\|1462520_1463207_-\|TIGR02234-family-membrane-protein	unknown	unknown	gnl\|CDD\|274046

Protein	Function_ID	Function_description	E-value
NZ_AP022584.1\|WP_067172866.1\|1451200_1452877_+\|thiol-reductant-ABC-exporter-subunit-CydC	gnl\|CDD\|274331	TIGR02868, ABC_transporter_ATP-binding_protein, thiol reductant ABC exporter, CydC subunit. The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex.	9.58292e-161
NZ_AP022584.1\|WP_083016234.1\|1449600_1451214_+\|thiol-reductant-ABC-exporter-subunit-CydD	gnl\|CDD\|227321	COG4988, CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones].	1.06973e-162
NZ_AP022584.1\|WP_095578227.1\|1454925_1455771_-\|acyl-CoA-thioesterase-II	gnl\|CDD\|224857	COG1946, TesB, Acyl-CoA thioesterase [Lipid metabolism].	7.26409e-118
NZ_AP022584.1\|WP_067172895.1\|1461589_1462408_-\|indole-3-glycerol-phosphate-synthase-TrpC	gnl\|CDD\|234710	PRK00278, trpC, indole-3-glycerol phosphate synthase TrpC.	7.02125e-131
NZ_AP022584.1\|WP_067172897.1\|1463199_1464738_-\|anthranilate-synthase-component-I	gnl\|CDD\|184152	PRK13571, PRK13571, anthranilate synthase component I; Provisional.	0
NZ_AP022584.1\|WP_008257742.1\|1455902_1457321_-\|pyruvate-kinase	gnl\|CDD\|180487	PRK06247, PRK06247, pyruvate kinase; Provisional.	0
NZ_AP022584.1\|WP_067172901.1\|1466483_1466831_-\|phosphoribosyl-AMP-cyclohydrolase	gnl\|CDD\|234598	PRK00051, hisI, phosphoribosyl-AMP cyclohydrolase; Reviewed.	1.43714e-66
NZ_AP022584.1\|WP_067172888.1\|1459443_1460259_-\|tryptophan-synthase-subunit-alpha	gnl\|CDD\|237285	PRK13111, trpA, tryptophan synthase subunit alpha; Provisional.	3.03293e-115
NZ_AP022584.1\|WP_083016101.1\|1446983_1448456_+\|cytochrome-ubiquinol-oxidase-subunit-I	gnl\|CDD\|376587	pfam01654, Cyt_bd_oxida_I, Cytochrome bd terminal oxidase subunit I. This family are the alternative oxidases found in many bacteria which oxidize ubiquinol and reduce oxygen as part of the electron transport chain. This family is the subunit I of the oxidase E. coli has two copies of the oxidase, bo and bd', both of which are represented here In some nitrogen fixing bacteria, e.g. Klebsiella pneumoniae this oxidase is responsible for removing oxygen in microaerobic conditions, making the oxidase required for nitrogen fixation. This subunit binds a single b-haem, through ligands at His186 and Met393 (using SW:P11026 numbering). In addition His19 is a ligand for the haem b found in subunit II.	0
NZ_AP022584.1\|WP_067172873.1\|1453384_1454782_-\|DUF2156-domain-containing-protein	gnl\|CDD\|225451	COG2898, COG2898, Uncharacterized conserved protein [Function unknown].	2.29921e-93
NZ_AP022584.1\|WP_139799098.1\|1446309_1446897_+\|DUF308-domain-containing-protein	gnl\|CDD\|225786	COG3247, HdeD, Uncharacterized conserved protein [Function unknown].	4.44124e-26
NZ_AP022584.1\|WP_083016115.1\|1464832_1465291_+\|peroxiredoxin	gnl\|CDD\|239315	cd03017, PRX_BCP, Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing and detoxifying hydroperoxides. The protein was named BCP based on its electrophoretic mobility before its function was known. BCP shows substrate selectivity toward fatty acid hydroperoxides rather than hydrogen peroxide or alkyl hydroperoxides. BCP contains the peroxidatic cysteine but appears not to possess a resolving cysteine (some sequences, not all, contain a second cysteine but its role is still unknown). Unlike other PRXs, BCP exists as a monomer. The plant homolog of BCP is PRX Q, which is expressed only in leaves and is cellularly localized in the chloroplasts and the guard cells of stomata. Also included in this subfamily is the fungal nuclear protein, Dot5p (for disrupter of telomere silencing protein 5), which functions as an alkyl-hydroperoxide reductase during post-diauxic growth.	3.92935e-57
NZ_AP022584.1\|WP_067172904.1\|1466827_1467616_-\|imidazole-glycerol-phosphate-synthase-subunit-HisF	gnl\|CDD\|234996	PRK02083, PRK02083, imidazole glycerol phosphate synthase subunit HisF; Provisional.	2.25849e-170
NZ_AP022584.1\|WP_083016118.1\|1465297_1466407_-\|calcium:proton-antiporter	gnl\|CDD\|223464	COG0387, ChaA, Ca2+/H+ antiporter [Inorganic ion transport and metabolism].	4.5951e-90
NZ_AP022584.1\|WP_067172880.1\|1457386_1457848_-\|DUF2752-domain-containing-protein	gnl\|CDD\|378499	pfam10825, DUF2752, Protein of unknown function (DUF2752). This family is conserved in bacteria. Many members are annotated as being putative membrane proteins.	2.71412e-16
NZ_AP022584.1\|WP_083016105.1\|1448497_1449538_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	gnl\|CDD\|376764	pfam02322, Cyt_bd_oxida_II, Cytochrome bd terminal oxidase subunit II. This family consists of cytochrome bd type terminal oxidases that catalyze quinol-dependent, Na+-independent oxygen uptake. Members of this family are integral membrane proteins and contain a protohaem IX centre B558. One member of the family, Klebsiella pneumoniae CydB, is implicated in having an important role in micro-aerobic nitrogen fixation in the enteric bacterium Klebsiella pneumoniae. The family forms an integral functional unit with subunit I, family Bac_Ubq_Cox, pfam01654.	1.10167e-98
NZ_AP022584.1\|WP_067172907.1\|1467617_1468418_-\|inositol-monophosphatase-family-protein	gnl\|CDD\|223559	COG0483, SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism].	2.00074e-62
NZ_AP022584.1\|WP_083016112.1\|1460255_1461515_-\|tryptophan-synthase-subunit-beta	gnl\|CDD\|235288	PRK04346, PRK04346, tryptophan synthase subunit beta; Validated.	0
NZ_AP022584.1\|WP_067172970.1\|1462520_1463207_-\|TIGR02234-family-membrane-protein	gnl\|CDD\|274046	TIGR02234, conserved_hypothetical_protein, trp region conserved hypothetical membrane protein. Members of this family are predicted transmembrane proteins with four membrane-spanning helices. Members are found in the Actinobacteria (Mycobacterium, Corynebacterium, Streptomyces), always associated with genes for tryptophan biosynthesis.	7.76289e-48

>NZ_AP022584.1|WP_067172880.1|1457386_1457848_-|DUF2752-domain-containing-protein
MLEDCDPRKVDRSVTQPGAGSHGLRRQLGYAGAGAAVVLGGALGYVGLVDPHDPASIYPPCPFKLLTGWNCPFCGGLRMTYDVVHGDLAAALHDNAFVLVGIPMLVLWLALRRARGAASVPRAALVTIVVATVVWTVLRNLPAFPLIPTVLGG
>NZ_AP022584.1|WP_008257742.1|1455902_1457321_-|pyruvate-kinase
MSRRGKIVCTLGPATNSDELILALVEAGMDVARLNFSHGDYADHKAAYERVRVASDATGRAVGVLADLQGPKIRLGRFATGPTYWADGETVRITVADCEGSHDRVSTTYKKLAEDAAVGDRVLVDDGKVCLVVDGIEGDDVICTVVEGGPVSNNKGISLPGMNVSAPALSEKDIEDLTFALDLGVDLVALSFVRSPADVELVHEVMDRVGRRVPVIAKLEKPEAVDNLEAIVLAFDAIMVARGDLGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDSMIENSRPTRAEASDVANAVLDGADAVMLSGETSVGKYPMAAVRTMSRIICAVEDNSTAAPPLTHVPRTKRGVISYAARDIGERLDAKALVAFTQSGDTVKRLARLHTPLPLLAFTAWPEVRSQLAMTWGTETFIVPMMTSTDGMIRQVDKSLLELGRYKRGDLVVIVAGAPPGTVGSTNLIHVHRIGEDDV
>NZ_AP022584.1|WP_095578227.1|1454925_1455771_-|acyl-CoA-thioesterase-II
MATLDLDRVSEDLFIGSHPSKNPMRTFGGQLMSQSFVASSRSLVRDDLPPSALSVHFINGGDTDKDIEYHVTRLRDERRFANRRVDAIQDGTLLCSAMVSYMAGGRGLEHGIEPPQVAEPHTQPTIGDLLRGYEETVPHFVNALQPIEWRYTNDPAWVMRTKGDRLPHNRVWVKALGEVPEDPVLHTATMVYSSDTTVLDSVITTHGLSWGFDRIFAASANHSIWFHRQVNFNDWVLYSTSSPVAADSRGLGTGHFFDRSGQPLATVVQEGVLKYFPSSRR
>NZ_AP022584.1|WP_067172873.1|1453384_1454782_-|DUF2156-domain-containing-protein
MNGPVVDVTAKPRVRERVVVSADSFAIRLAGALALLCAACWFIEILARHHSQPNWHFADRLAWSVTVLVAVAWIARGVFLGRPVTTMHAIAAALFVLAGLGLHVLSFDLLGDIVIASSGMVLMWPMTSHPRPADLPRVWKLIEATGDDALAPFTMQTGKSYHFTADGTAALAYRTRMGIAVVGGDPIGDEEHFPELVADFAATCHAHGWRIAVVGCGERRLGLWNDSAALGQSLHAIPIGRDVVVDVSGFDMVGRKYRNLRQAVKRTHNCGVTTEIVAEQELGDTLLAELTEVVRESSKGARADRGFHMNLDGVLEGRFPGIQLIIARDAAGKVQAFHRYATAGGGSDITLDVPWRRRGAPNGLDERLSVDMIMAGKDNGAQRVSLAFAAFPEIFDDKNRGWTQRVFYRLIHILDPLIALESLYRYVRKWHALDARRYALISWTQIVPLLFVLLSLEFMPRRRHL
>NZ_AP022584.1|WP_067172869.1|1452894_1453206_-|UsfY-protein
MGDTFRDPLDHVRTTRPHAGESLIDVMSWPGYLFMVVGVIAVFRCLVALGTGHDGRSLIGGAIAIVAMTVGLLWLKVERGRVRKLENRWYEEHPEAYRQRPAS
>NZ_AP022584.1|WP_067172866.1|1451200_1452877_+|thiol-reductant-ABC-exporter-subunit-CydC
MPRSDSTATRGHEPLLAAAALLRPRLPRVLTAITLGVLSLGSALALAGIAAWLITRAWQMPPVLDLSVAAVAVRLFAISRAVLHYCERLVTHDTALRAAGTARVQVYQRLARGPAAAAVRLHSGELVARVGADVDELANVLVRALVPIGVAAVLALAATAVVATISPAAAVVLAICLLIAGFLAPRLAGRAAATQEDIARQHHSERDTSAMIALEHAPELRVAGLLPDVIAESQRRQRAWGGALDAAAKPAAIAEAMPTAAVGASVLGAVVAGIGLAHAVAPTTLAVLMLLPLSAFEAMTPLPAAAVQLTRSRIAARRLLELTAEGPRAALETTQPAPRPVGTGRLSADVRCGHGAAGSIRVELDLAPGARLAVTGASGSGKTTLLMTLAGLLPPLDGQVLLDGVALTQFGEADLRCAIGFFAEDAHIFATTVRDNLLVARGDCRDDELTAALGAVGLGTWLAGLPDGLATVLTGGAQALSAGQRRRLLLARAVLSPARIVLLDEPTEHLDVSDADEVLRDLLAPDSRLLSPERTVVVATHHLGTGIGCDELRVDREA
>NZ_AP022584.1|WP_083016234.1|1449600_1451214_+|thiol-reductant-ABC-exporter-subunit-CydD
MRRYLVAAVGCGVLISACAIASAIVLARIVARAVDEPPGRGLHTWWGPLSLLLALWVIRAAAHWFQARLGHRGASAVIADLSGQVLDAVTARQPGELAAQRDAAAVVVTRGLDGLRPYLTGYLPTLLLAAILTPATVAVIAAYDLKSTAIVAITLPLIPIFMVLIGLATRDRSTAALAAMTTLQARLLDLIAGIPTLRALGRGAGPERRIAELAAAHRRSAMATLRIAFLSALVLELLATLGVALIAVGIGLRLVFGEMTLTTGLTVLLLAPDVYWPLRRIGVEFHAAQDGRAAAAEAFALIGGQTAPPTGTRTVTARGARIRLEHLTVTGRDGQAPRDLNAAIEPGTVTVLTGRNGAGKSTTLQAIAGITAPSSGRVTVAGVDVADLEPARWWRQLSWLPQRPVLVPGTVDENLALLGELEDRETACAVSGFGAVLAELPEGRDTVLGRGGVGLSLGQRQRLGLARALGSAADVLLLDEPTAHLDARTEERVLQAIVERARAGATVIVVGHREPVLAIGDQVVEVVADREVRYAPV
>NZ_AP022584.1|WP_083016105.1|1448497_1449538_+|cytochrome-d-ubiquinol-oxidase-subunit-II
MGLQEVWFGIIGVLFLGFFILEGFDFGVGMLMEPFARVGIGEAEPLRRTALNTIGPVWDGNEVWLIVGGAAMFAAFPGWYATVFSTLYLPLLAILFGMIVRAVAIEWRGKIDDTKWRGWADFGIAAGSWLPAVLWGVAFAVLVRGLPVDADGHIHLSIADVLNAYTVLGGLATAGLFLLYGAVFVALKTSGAIREDAYRFGVWLSLPVTGLVAGFGLWTQVAYGKDWTWLVLAAAVVAQLAAVLLVWRRASDGWAFTCVALVVAAVVILLFGSLYPNLVPSTLNKQWSLTIYNASSTHYTLKVMTWVTAFMAPLTVVYQAWTYWVFRQRISADRIPAPIGLARRPS
>NZ_AP022584.1|WP_083016101.1|1446983_1448456_+|cytochrome-ubiquinol-oxidase-subunit-I
MNVVDISRWQFGIVTVYHFIFVPLTIGLAPLIAIMQTVWVATGNTAWYRLTKFFGKLFLINFAIGVATGIVQEFQFGMNWSEYSRFVGDIFGAPLAMEGLFAFFFESTFIGLWIFGWSRLPKLLHLACIWIVAIGVNASAFFIIAANSFMQHPVGAHYNPVTRRAELDSIFALLSNNTAQAAFSHTVAGALLTAGTFVAAVSTWWMVRSRTTGSTTEAAETEARIMFRPAAILGSGVVLLAAVGLFFTGDRQGKLMFVQQPMKMASAEALCHTQTDPDFSVLTIGTHNNCGSVTEVIKAHYVLPFLAEGKLSGVTLQGVNELQQQYQHRFGPDDYRPNLFVTYWSFRLMIGFLVFPVMFALAVLWLTRAGRTPKSRWVSWFALLTIPTPFLANISGWVFTEMGRQPWVVAPNPTGDPLVRMTVREGVSNHVPGMVITSLVTFTLVYAVLAVLWFFLLKRYTVEGPLEHDAEPAPPQAPSADEVAPLSFAY
>NZ_AP022584.1|WP_139799098.1|1446309_1446897_+|DUF308-domain-containing-protein
MTISPGSPGTHPVPSLLPHLWKSALLSGILSLVLGVLVLAWPGISILVAAVAFGVYLLITGIAQVVFAFSLHVSAGSRILLFISGAASLILALLAFRHFGQGYAILLLAIWIGIGFIFRGVATTISAVSDPHLPGRGWNIFLGALSLLAGIVVLASPFESIVTLAIVVGAWFVVIGIFEIISSFGIRKASNTLSG
>NZ_AP022584.1|WP_067172888.1|1459443_1460259_-|tryptophan-synthase-subunit-alpha
MTVKQSETSRLGPIFDVCRNDGRAALIGYLPTGYPDVRTSLDGMVALVESGCDIVEVGVPYSDPGMDGPTIAKATEAALHGGVRVRDTLAAVEAISAAGGHAVVMTYWNPVLRYGIEAFARDLASAGGYGLITPDLIPDEAGQWLAASEEYGLDRIFLVAPSSTPQRLAMTVEASRGFVYAASTMGVTGARDVVSNAAPELVGRVKGISEIPVGVGLGVRSGEQAAQIGGYADGVIVGSALVSALGDGGLTALGALTEELAAGVRRRAAAS
>NZ_AP022584.1|WP_083016112.1|1460255_1461515_-|tryptophan-synthase-subunit-beta
MVDLSRPDLPLPSAAIAEPTRHEPDAGGHFGVYGGRYVAEALMAVIEEVTAAYEKERVNQDFLDTLDYLQAHYAGRPSPLYEAPRLSEQAGARIFLKREDLNHTGSHKINNVLGQALLAQRMGKKRVIAETGAGQHGVATATACALLGLDCVIYMGAVDTERQALNVARMRLLGATVVSVQSGSRTLKDAINEAFRDWVTNADNTFYCFGTAAGPHPFPAMVRDFQRIIGLEARAQIQAQAGRLPDAVMACIGGGSNAIGIFHPFIDDPGVRLIGFEAAGDGVETGRHAATFSGGSPGAFQGSFSYLLQDEDGQTIESHSISAGLDYPGVGPEHAWLRESGRAEYRPITDSEAMEAFRTLCRTEGIIPAIESAHAVAGALKVAPELGTAAIIVVNLSGRGDKDVETAAQWFGLLGSSDR
>NZ_AP022584.1|WP_067172895.1|1461589_1462408_-|indole-3-glycerol-phosphate-synthase-TrpC
MSPATVLDSILEGVRADVAAREALISLSEIKAAAAAAPPPRDVMAALREPGIGVIAEVKRASPSAGSLATIADPAKLARAYEDGGARIISVLTEERRFHGSLDDLDAVRAAVSIPILRKDFVVQPYQIHEARAHGADMLLLIVAALEQSALVSMLDRTESLGMTALVEVHTEEEADRALKAGANVIGVNARDLATLAVDRDCFARIAPGLPSNVIRIAESGVRGTADLLAYAGAGADAVLVGEGLVKSGDPRAAVADLVTAGTHPSCPKPAR
>NZ_AP022584.1|WP_067172970.1|1462520_1463207_-|TIGR02234-family-membrane-protein
MAEARPKRRRLDARWLIRIAQVTLVVAAGALWVASRLPWVVIRSFDGLGPPKEVTLSGGAWSTALLPLAMLLLAAAVAAIAVRGWLLRALAGLLALASLAVGYLGISLWALPDVAVRGAELAHVSVMSLVGSERRYWGAGVTVTAAAFALIAAVLLLRSASDPGSARSSAMKYTTPATRRSIARRNDADGAMLEGRQTPEMSERMIWDALDEGRDPTDAPSESDTEGR
>NZ_AP022584.1|WP_067172897.1|1463199_1464738_-|anthranilate-synthase-component-I
MHAHLAATTSREDFRQLAAEHRVVPVTRKVLADSETPLSAYRKLAANRPGTFLLESAEHGRSWSRWSFIGAGAPSALTVRDGAATWLGVVPRDAPTGGDPLRALRATLELLATGPLSGLPPLSGGMVGFFAYDLVRRLERLPELAADDLGLPDMLLLLATDVAAVDHHEGTITLIANAVNWNGTDERVDEAYDDAVARLDVMTAALSQPLSSTVATFDRPEPRYRAQRSVEEYGKIVDYLVEQIAAGEAFQVVPSQRFEMDTDVDPLDVYRMLRVTNPSPYMYLLHVPNDAGGTDFSIVGSSPEALVTVADGVATTHPIAGTRWRGETDEEDQLLEKELLADEKERAEHLMLVDLGRNDLGRVCAPGTVRVEDYSHIERYSHVMHLVSTVTGLLGEGRTALDAVTACFPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVVGYLDFAGNADFAIAIRTALMRAGTAYVQSGGGVVADSNGPYEYTEATNKARAVLSAIAAAETLTEPGARRDG
>NZ_AP022584.1|WP_083016115.1|1464832_1465291_+|peroxiredoxin
MKTGETVADFELPDQTDTPRKLSELLSSGPVVLFFYPAAMTPGCTKEACHFRDLASEFAAVGANRVGISADPVQKQAKFADLRNFDYPLLSDTDGTVAAQFGVKRGLLGKLMPVKRTTFVIDTDRTVLEVISSEFNMDTHADKALAMLRARS
>NZ_AP022584.1|WP_083016118.1|1465297_1466407_-|calcium:proton-antiporter
MSKWLSRDVLSWNVVVPVLAVVVLAGIWGEKLGPVLVAVAALFLVGAVVAAVHHAEVVAHRVGEPFGSLILAAAVTIIEVALIVALMTSGGNEAATLARDTAFAALMITTNGIAGLSLLLGSRRYGVTLFNAEGAGAALATVTTVATLSLVLPAFTTGHPGREFTRSQLAFTAIATLFVYLLFVFTQTVRHRDFFLPIAQRGQKKRAFEDESHADPPTRRQALSSLVLLLCALVAVVGLAEEESPAVEHAVMVAGLPQSFVGVIIAALVLLPETLAAARAARKGRIQTSLNLAYGSAMASIGLTIPVIALASVWLKGPLVLGLGSVQLVLLALTVVISVLTVVPGRATRLQGEVHLVLLAAYVFLSISP
>NZ_AP022584.1|WP_067172901.1|1466483_1466831_-|phosphoribosyl-AMP-cyclohydrolase
MTLDPQIAARLKRNADGLIAAVVQERSSGDVLMVAWMDDAALARTLETREATYYSRSRREQWVKGATSGHTQYVHSVRLDCDGDTVLLTVDQVGGACHTGDHSCFDADALLQPER
>NZ_AP022584.1|WP_067172904.1|1466827_1467616_-|imidazole-glycerol-phosphate-synthase-subunit-HisF
MHANHSGLAVRVIPCLDVDGGRVVKGVNFENLRDAGDPVELAAAYDAEGADELTFLDVTASSSGRTTMLDVVRRTAEQVFIPLTVGGGVRTVADVDVLLRAGADKVSINTAAIARPELLAEMARQFGSQCIVLSVDARTVPSGSVPTPSGWEVTTHGGRRGTGLDAVEWASRGADLGVGEILLNSMDADGTKAGFDLEMLQAVRSAVTVPVIASGGAGAAEHFAPAIEAGADAVLAASVFHFRELTIGQVKAAMAAEGITVR
>NZ_AP022584.1|WP_067172907.1|1467617_1468418_-|inositol-monophosphatase-family-protein
MDVDALVETASAILDDATDPFLAGHRADSAVRKKGNDFATEVDLAIERQVVAALVDATGIGVHGEEFGGSDVDSPWVWVLDPVDGTFNYAAGSPMAGILLGLLHHGDPVAGLTWLPFMDQRYTAVSGGPLRKNGVAQPRLAAIDLADALVGAGSFSADARGRFPGRYRIAVLENLSRVSSRLRMHGSTGIDLAFVADGILGAAISFGGHVWDHAAGVALVRAAGGVVTDLAGEPWSPASDSALAAGPAAHAEILDLLRSTGRPEDY

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Crispr_ID: NZ_AP022584_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022584_3

4219711-4219792

Orphan

Consensus_repeat	Method
GCAGCGGGTCACCCGCATCGATT	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_AP022584_3

>merge|NZ_AP022584|3|4219711-4219792|CRISPRCasFinder
GCAGCGGGTCACCCGCATCGATTCCCGGGCGATCGGCAGCGCGGCGCTTGCCGCCGGGCGCAGCGGGTCGCCCGCATCGATT

>NZ_AP022584|3|3|4219711-4219792|CRISPRCasFinder
GCAGCGGGTCACCCGCATCGATT	CCCGGGCGATCGGCAGCGCGGCGCTTGCCGCCGGGC
GCAGCGGGTCGCCCGCATCGATT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022584.1\|WP_067173162.1\|4216713_4217325_+\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NZ_AP022584.1\|WP_067173167.1\|4215495_4216221_-\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|223929
NZ_AP022584.1\|WP_067173577.1\|4212272_4213535_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|367049
NZ_AP022584.1\|WP_083016575.1\|4217765_4218473_-\|glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|225974
NZ_AP022584.1\|WP_083016585.1\|4213579_4215004_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NZ_AP022584.1\|WP_082991293.1\|4226465_4226795_-\|DUF732-domain-containing-protein	unknown	unknown	gnl\|CDD\|368380
NZ_AP022584.1\|WP_163648944.1\|4220863_4222669_-\|2-isopropylmalate-synthase	unknown	unknown	gnl\|CDD\|235154
NZ_AP022584.1\|WP_083016582.1\|4215052_4215490_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|378454
NZ_AP022584.1\|WP_163648946.1\|4225418_4226420_+\|DUF4185-domain-containing-protein	unknown	unknown	gnl\|CDD\|379383
NZ_AP022584.1\|WP_067166493.1\|4224220_4225255_+\|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|237845
NZ_AP022584.1\|WP_083016588.1\|4210399_4212259_+\|DNA-polymerase-III-subunits-gamma/tau	unknown	unknown	gnl\|CDD\|237866
NZ_AP022584.1\|WP_067173153.1\|4218465_4219695_-\|Mur-ligase-family-protein	unknown	unknown	gnl\|CDD\|223840
NZ_AP022584.1\|WP_083016579.1\|4217331_4217754_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022584.1\|WP_083016565.1\|4229052_4230363_+\|ergothioneine-biosynthesis-glutamate--cysteine-ligase-EgtA	unknown	unknown	gnl\|CDD\|274583
NZ_AP022584.1\|WP_067166486.1\|4226994_4227420_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368014
NZ_AP022584.1\|WP_083016572.1\|4219854_4220847_+\|DEDDh-family-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|180377
NZ_AP022584.1\|WP_082991490.1\|4216355_4216700_+\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|234669
NZ_AP022584.1\|WP_067166502.1\|4228211_4228874_+\|sensor-domain-containing-protein	unknown	unknown	gnl\|CDD\|372884
NZ_AP022584.1\|WP_067166496.1\|4222954_4224220_+\|aspartate-kinase	unknown	unknown	gnl\|CDD\|235843
NZ_AP022584.1\|WP_067166482.1\|4227561_4228083_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369035

Protein	Function_ID	Function_description	E-value
NZ_AP022584.1\|WP_067173162.1\|4216713_4217325_+\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	1.0038e-111
NZ_AP022584.1\|WP_067173167.1\|4215495_4216221_-\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|223929	COG0860, AmiC, N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane].	6.96702e-44
NZ_AP022584.1\|WP_067173577.1\|4212272_4213535_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|367049	pfam02353, CMAS, Mycolic acid cyclopropane synthetase. This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.	6.66366e-131
NZ_AP022584.1\|WP_083016575.1\|4217765_4218473_-\|glutamine-amidotransferase	gnl\|CDD\|225974	COG3442, COG3442, Predicted glutamine amidotransferase [General function prediction only].	4.5648e-115
NZ_AP022584.1\|WP_083016585.1\|4213579_4215004_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	3.74996e-38
NZ_AP022584.1\|WP_082991293.1\|4226465_4226795_-\|DUF732-domain-containing-protein	gnl\|CDD\|368380	pfam05305, DUF732, Protein of unknown function (DUF732). This family consists of several uncharacterized Mycobacterium tuberculosis and leprae proteins of unknown function.	7.65014e-09
NZ_AP022584.1\|WP_163648944.1\|4220863_4222669_-\|2-isopropylmalate-synthase	gnl\|CDD\|235154	PRK03739, PRK03739, 2-isopropylmalate synthase; Validated.	0
NZ_AP022584.1\|WP_083016582.1\|4215052_4215490_+\|SRPBCC-family-protein	gnl\|CDD\|378454	pfam10604, Polyketide_cyc2, Polyketide cyclase / dehydrase and lipid transport. This family contains polyketide cylcases/dehydrases which are enzymes involved in polyketide synthesis. It also includes other proteins of the START superfamily.	1.31928e-08
NZ_AP022584.1\|WP_067166493.1\|4224220_4225255_+\|aspartate-semialdehyde-dehydrogenase	gnl\|CDD\|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	0
NZ_AP022584.1\|WP_083016588.1\|4210399_4212259_+\|DNA-polymerase-III-subunits-gamma/tau	gnl\|CDD\|237866	PRK14952, PRK14952, DNA polymerase III subunits gamma/tau.	0
NZ_AP022584.1\|WP_067173153.1\|4218465_4219695_-\|Mur-ligase-family-protein	gnl\|CDD\|223840	COG0769, MurE, UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane].	3.49373e-77
NZ_AP022584.1\|WP_163648946.1\|4225418_4226420_+\|DUF4185-domain-containing-protein	gnl\|CDD\|379383	pfam13810, DUF4185, Domain of unknown function (DUF4185).	4.16805e-53
NZ_AP022584.1\|WP_083016565.1\|4229052_4230363_+\|ergothioneine-biosynthesis-glutamate--cysteine-ligase-EgtA	gnl\|CDD\|274583	TIGR03444, EgtA_Cys_ligase, ergothioneine biosynthesis glutamate--cysteine ligase EgtA. Members of this bacterial protein family, EgtA, resemble the glutamate--cysteine ligase of the two-step pathway for glutathione (GSH) biosynthesis, but instead are involved in the biosynthesis of the histidine-derived thiol, ergothioneine (EGT). Successful in vitro reconstitution of EGT biosynthesis using EgtBCDE and gamma-L-glutamyl-L-cysteine suggests that this enzyme is a bone fide glutamate--cysteine ligase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	2.22293e-165
NZ_AP022584.1\|WP_067166486.1\|4226994_4227420_+\|hypothetical-protein	gnl\|CDD\|368014	pfam04592, SelP_N, Selenoprotein P, N terminal region. SelP is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues, and accounts for more than 50% of the selenium content of rat and human plasma. It is thought to be glycosylated. SelP may have antioxidant properties. It can attach to epithelial cells, and may protect vascular endothelial cells against peroxynitrite toxicity. The high selenium content of SelP suggests that it may be involved in selenium intercellular transport or storage. The promoter structure of bovine SelP suggest that it may be involved in countering heavy metal intoxication, and may also have a developmental function. The N-terminal region of SelP can exist independently of the C terminal region. Zebrafish selenoprotein Pb lacks the C terminal Sec-rich region, and a protein encoded by the rat SelP gene and lacking this region has also been reported. N-terminal region contains a conserved SecxxCys motif, which is similar to the CysxxCys found in thioredoxins. It is speculated that the N terminal region may adopt a thioredoxin fold and catalyze redox reactions. The N-terminal region also contains a His-rich region, which is thought to mediate heparin binding. Binding to heparan proteoglycans could account for the membrane binding properties of SelP. The function of the bacterial members of this family is uncharacterized.	3.72346e-05
NZ_AP022584.1\|WP_083016572.1\|4219854_4220847_+\|DEDDh-family-exonuclease	gnl\|CDD\|180377	PRK06063, PRK06063, DEDDh family exonuclease.	0
NZ_AP022584.1\|WP_082991490.1\|4216355_4216700_+\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|234669	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein.	5.74363e-42
NZ_AP022584.1\|WP_067166502.1\|4228211_4228874_+\|sensor-domain-containing-protein	gnl\|CDD\|372884	pfam14032, PknH_C, PknH-like extracellular domain. This domain is functionally uncharacterized. It is found as the periplasmic domain of the bacterial protein kinase PknH. The domain is also found in isolation in numerous proteins, for example the lipoproteins lpqQ, lprH, lppH and lpqA from M. tuberculosis. This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 268 amino acids in length. There are two completely conserved C residues that are likely to form a disulphide bond. A second pair of cysteines are less well conserved probably form a second disulphide bond. It seems likely that this domain functions to bind some as yet unknown ligand.	1.75681e-35
NZ_AP022584.1\|WP_067166496.1\|4222954_4224220_+\|aspartate-kinase	gnl\|CDD\|235843	PRK06635, PRK06635, aspartate kinase; Reviewed.	0
NZ_AP022584.1\|WP_067166482.1\|4227561_4228083_+\|hypothetical-protein	gnl\|CDD\|369035	pfam06682, SARAF, SOCE-associated regulatory factor of calcium homoeostasis. SARAF is as family of eukaryotic proteins embedded in the ER. SARAF is SOCE-associated regulatory factor, where SOCE is store operated calcium entry. ie a mechanism governing calcium homoeostasis in the cell and the mitochondria. SOCE involves the enabling of Ca2+ release-activated Ca2+ (CRAC) channels. SARAF is a single pass ER membrane protein whose systolic-facing domain is responsible for activity and whose luminary-facing domain carries out a regulatory function in conjunction with another membrane protein STIM, an ER single pass membrane protein that detects changes in ER Ca2+ levels through its EF-hand, conserved Ca2+ binding domain. STIM is the major target for SARAF regulation, and thus SARAF negatively regulates the SOCE entry of calcium into cells protecting them from overfilling.	0.00314657

>NZ_AP022584.1|WP_067173153.1|4218465_4219695_-|Mur-ligase-family-protein
MLTTRARLALAAGASARWASRVTGRGAGAMIGGLIAMTLDRSVLSQLATGRRTVVVTGTNGKSTTTRMTSAALETLGPVATNAEGANMDAGLVAALAANRHASLAALEVDEMHVPHVSDAVEPGVVVLLNLSRDQLDRVGEINVIERTLRAGLARHPNAVVVANCDDVLMTSAAYDSPNVVWVAAGGSWSNDSVSCPRSGEVIVREHGHWFSTGADFKRPSPQWWFDDHALHGPDGLSLPMRLTLPGAVNRGNAAQAVAAAVALGADPTAAVAAVSAVDEVAGRYRIVRVGDHEVRMLLAKNPAGWQEALSMVDKRAAGVVISVNGQVPDGEDLSWLWDVRFEHFEQTEVVAAGERGTDLAVRLGYAGVEHSLVHDTVAAIASCPPGRVEVVANYTAFLQLQRALARHG
>NZ_AP022584.1|WP_083016575.1|4217765_4218473_-|glutamine-amidotransferase
MADSVVRIGLVLPDVMGTYGDGGNALVLRQRLLLRGIPAEIVEITLADPVPESLDLYTLGGAEDYAQRLATRHLIKHPGLQRAAERGAPVLAICAAVQVLGHWYETSAGERVDGVGMLDATTSPQEARTIGELATKPLLAGLTERLTGFENHRGGTVLGPSAAPLGAVVKGAGNRTGDGFDGVVQGSVIATYMHGPCLARNPQLADLLLTTVVGELSPLPMPEVDLLRRERLAAR
>NZ_AP022584.1|WP_083016579.1|4217331_4217754_-|hypothetical-protein
MTTIRQSLAAGAALVTAFIASSTPAHANPEVLNGRYNVLYADNDKPTTWLFVPCGSDCILATSQDGGTFVISWEFHLANGRWTHSGTAPAPCPNGASAPVTVNYSFDAVTLAGEGQQTTTDACGGEAGKTFTRSFQLSKT
>NZ_AP022584.1|WP_067173162.1|4216713_4217325_+|recombination-protein-RecR
MFEGPVQDLIDELGKLPGIGPKSAQRIAFHLLSVEPPDIDRLTAVLAKVRDGVRFCAVCGNVSDNERCRICADPRRDGSQVCVVEEPKDVQAVERTREFRGRYHVLGGALDPLSGVGPEQLRIRELLSRIGERVDDVDITEVIIATDPNTEGEATATYLVRMLRDIPGLTVTRIASGLPMGGDLEFADELTLGRALAGRRAMV
>NZ_AP022584.1|WP_082991490.1|4216355_4216700_+|YbaB/EbfC-family-nucleoid-associated-protein
MQPGGDMSALLAQAQQMQQKLMEAQQQLANAEVHGQAGGGLVSVVVKGSGEVVAVKIDPSVVDPSDVETLQDLIVGAMADASKQVTRMAQERLGSLAGGFGAPPGQPPAPAPGI
>NZ_AP022584.1|WP_067173167.1|4215495_4216221_-|N-acetylmuramoyl-L-alanine-amidase
MAVGVLVAASTAITPAAWGVPSNIAGMVVFIDPGHNGSNDASINRQVPTGRGGTKDCQASGTASTAGYQEHTFTWDTALRVRAELTALGVRTALARANDTGLGPCVDERASMANALHPNAILSIHADGGPPSGRGFHVNYSAPPLNQAQAGPSVQYARIMRDQMQASGIPPANYIGQNGLYGRSDLAGLNLAQYPSVLVECGNMKNPADSALMQSAEGRQKYADAMVRGVAGFLASQGQAR
>NZ_AP022584.1|WP_083016582.1|4215052_4215490_+|SRPBCC-family-protein
MGQVSADSTILINAEPAATLAAVADYQTVRPKILSPQYSDYQVLQGGQGAGTVAKWRLQATKSRVRDVQVNVDVAGHTVIEKDANSTMVINWTVAPAGPGSSVTVKTTWTGAGGVKGFFEKTFAPLGLKRIQGEVLDNLKKELES
>NZ_AP022584.1|WP_083016585.1|4213579_4215004_-|FAD-binding-oxidoreductase
MHRPLSKTRVYVVPVLGSALSPHKSGVDRLLASYRSIPATSAVRLAKPTSNLFRARTKRDAPGLDTSGLTGVLSVDPETRTADVAGMCTYADLVAATLPYGLSPLVVPQLKTITLGGAVSGLGIESSSFRNGLPHESVLEMDILTGAGDLLTTSRTQHPDLFRAFPNSYGTLGYSTRLRIELESVAPFVALRHIRFRSLPALIAAVERIIDTGGQGGTPVDYLDGVVFSADESYLCVGRRTTTPGPVSDYTGKDIYYQSIRHDAAGPEATKDDRLTMHDYFWRWDTDWFWCSRAFGAQNPRLRRWWPRRYRRSSVYSKLIAMDQRFGLSDRIEARNGRPPRERVVQDVEVPVERTCDFLEWFLDNVPITPIWLCPLRLRDRHGWPLYPMRPDHTYVNVGFWSSVPGGATEGATNRMIEAKVSELDGHKSLYSDSFYSREDFDELYGGEAYNTVKKTYDPDSRLLDLYAKAVQRR
>NZ_AP022584.1|WP_067173577.1|4212272_4213535_-|class-I-SAM-dependent-methyltransferase
MAEILEVFAATGRHPLKFTAYDGSTAGSEDAELGLDLRSPRGATYLATAPGELGLARAYVSGDLQAYGVHPGDPYQLLKTLTDRVEFKRPPARVLANVVRSLGVERLLPVAPPPQEALPRWRRIADGLMHTKTRDAEAIHHHYDVSNTFYELVLGPSMTYTCAVYPDADATLEEAQENKYRLIFEKLRLKAGDRLLDVGCGWGGMVRYAARRGVRVIGATLSAEQAKWAQQAIAEEGLADLAEVRHSDYRDVGEAAFDAVSSIGLTEHIGVKNYPAYFGFLKSKLRTGGLLLNHCITRHDNTSTSFAGGFTDRYVFPDGELTGSGRITSDVQDCGFEVLHAENFRHHYAMTLRDWCRNLVENWDAAVSEVGLPTAKVWGLYMAASRVAFEQNNLQLHHVLAAKTDARGDDDLPLRPWWTA
>NZ_AP022584.1|WP_083016588.1|4210399_4212259_+|DNA-polymerase-III-subunits-gamma/tau
MALYRKYRPATFAEVVGQEHVTEPLSIALEAGRINHAYLFSGPRGCGKTSSARILARSLNCAQGPTATPCGVCDSCLALAPNAPGSIDVVELDAASHGGVDDTRELRDRAFYAPAQSRYRVFIVDEAHMVTTAGFNALLKIVEEPPEHLIFIFATTEPEKVLPTIRSRTHHYPFRLLPPKTMRALIGRICEQEGVVVDDAVYPLVIRAGGGSPRDTLSVLDQLVAGAEGAHVTYQRALGLLGATDMALIDDAVDALAAADAAALFGAVESVIDAGHDPRRFATDLLERFRDLILLQAVPDAAARGVVDGPEDVLERMRDQSTRLGTATLTRYAEVVQAGLGEMRGATAPRLLLEVVCARLLLPSASDTEAALLQRVERIETRLDMSIPGSDTAAGAPRSAPAEPVEQPVRFTRPSAAAAKPEPKAEPKPEPKAEPKPEPAPTPEPATAPVPPPAPEPAPAAESPSAPGELNAAAVRSMWSTVRDKVRQRSRTTEVMLAGATVRAIEGNTLVLSHESAPLAKRLCEQRNADVIAEALKDALGVNWRVRCEAGAPAPVAANPLTPKPEEPAPEPDSARRAEEEHMLAEAVRDEPPGPRRDPEEVALELLQTELGARRIDNG
>NZ_AP022584.1|WP_083016572.1|4219854_4220847_+|DEDDh-family-exonuclease
MSAVCWGRPASEPDAGWAVIDVETSGFRPGQARIISLAVLGLDADGEVERSVVSLLNPGVDPGPTHVHGLTAAMLEDQPQFADVAADVIDVLRGRTLVAHNVAFDYAFLAAEAELADIELPVDSVMCTVELARRLDLGVDNLRLETLAAHWSVTQERPHDAFDDAMVLTGVLASALKLARDGDIWLPVHPVTRRRWPNGRVTHDELRPLKVLASRMPCPYLNPGPYVGGRPLVQGMRVALAAEVGRTHEELVERILHAGLAYSDAVDRETSLVVCNDPAPEQGKGYLARKLGVPVISDATFIDRVGAVIGGTSMDDFTDTTDSDPQLALF
>NZ_AP022584.1|WP_163648944.1|4220863_4222669_-|2-isopropylmalate-synthase
MTVTSNPDAFSSTRSIVKPAGPPRPGQPAWNPQRGSSMPVNRYRPFADEVEAIRLADRSWPDRVITSAPLWCAVDLRDGNQALIDPMSPTRKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIITDGAIPDDVTIQVLTQCRPELIERTFEACHGAPQAIVHFYNSTSILQRRVVFRAEQAAVQAIATEGARKCVEEAAKHPGTRWRFEYSPESYTGTELEYAKQVCDAVGEIIGPTPENPIIFNLPATVEMATPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGYQAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDQMKVDADAADTDVEDMLWQVPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYIMKADHGLALPRRLQIEFSQVVQKISEGEGGEVSPKEMWDAFSEEYLAPVWPLERVKQRVDASEEDSGVTSIAATVKLNGAETEISGAGNGPLAAFVHALGDVGFDVAVLDYSEHAMSSGDDAQAAAYVEASVNGRTVWGVGIAPSITTASLRAVVSAVNRAARA
>NZ_AP022584.1|WP_067166496.1|4222954_4224220_+|aspartate-kinase
MALVVQKYGGSSVANADRIRRVAERIVATKKQGNDVVVVVSAMGDTTDDLMDLAQQVCPAPPPRELDMLLTAGERISNALVAMAIESLGAQARSFTGSQAGVITTGTHGNAKIIDVTPGRLQTALDEGRVVLVAGFQGVSQDTRDVTTLGRGGSDTTAVALAAALRADVCEIYTDVDGIFSADPRIVHNARKLDTVTFEEMLEMAACGAKVLMLRCVEYARRYNIPVHVRSSYSENPGTVVVGSIKDIAMEDPILTGVAHDRSEAKVTVVGIPDIPGYAARVFRALADADVNIDMVLQNVSKVEDGKTDITFTCSRDSGPTAVAKLDALKDEIGFSQLLYDDHVGKVSLIGAGMRSHPGVTATFCESLAEVGVNIELISTSEIRISVLCRDTELDKAVVALHEAFGLGGEESATVYAGTGR
>NZ_AP022584.1|WP_067166493.1|4224220_4225255_+|aspartate-semialdehyde-dehydrogenase
MVAIGVVGATGQVGQVMRKLLDERDFPATSVRFFASARSQGRKLEFRGQEIEVEDAATADPAGLDIALFSAGKTMSLVQAPRFAAAGVTVIDNSSAWRKDPDVPLVVSEVNFASDAANRPKGIIANPNCTTMAAMPVLKVLHDEAGLQRLVVSSYQAVSGSGIAGVEELSTQARAVIDGAEQLVQDGSAVPFPAPKTYVAPIAFNVVPLAGSLVDDGSGETDEDQKLRHESRKILGIPDLAVSGTCVRVPVFTGHSLSINAEFARPLSPQRARELLDGAPGVKVVAVPTPLAAAGVDESLVGRIRQDPGVPDGRGLALFVSGDNLRKGAALNTIQIAELLAAQR
>NZ_AP022584.1|WP_163648946.1|4225418_4226420_+|DUF4185-domain-containing-protein
MMRIGPTAGTGTPTGDYGIGATDLCEFVEFPTELLQVCGDSFAGQGVGFGGWYAPVALHVDTTSVDDPAGVRYTGVTGISHPLLADPAPPDASQLPAGVVQINRRNYLMVTTTKDLEPQSSRLVTAEPARAGWQTIPDSQRPASYQGGSQTQISGYYDPIPTPESPTGWVYIVADSFTRRDPVVLYRATPQTFTDRSRWQGWAAGPHGGWGKPPTPLWPDAVGEMCIRQIDGKAVLSYFNAVTGNMEVRVADDPTALGDAPVTTVVQHDEWPEPAESLPPPYDNRLAQPYGGYISPGSTLDEMRIFVSQWDTRARVAAPYRVIQFAVNPFKPE
>NZ_AP022584.1|WP_082991293.1|4226465_4226795_-|DUF732-domain-containing-protein
MLFRNVFIAGAAVAAAAIAGTGFAAPARADETAYLNDLHNAGIVDASGDSALLQVGWDLCRQLSDGASLEQLRAQVLYNSDTGQGSEGVGPAQANDVVNYAIVDLCPSA
>NZ_AP022584.1|WP_067166486.1|4226994_4227420_+|hypothetical-protein
MSETSETPTVRTSTATAPAAAAAAYRAPRVFQLAAWVAIVAGIVFIVAVIFFTGFILGHRGGHHGHHHKHHHHHAMLHHRGPGGPGGPGGVAPGGPNGPGATTSPAPSSVRPSGMAPGQLPASVFHSAASHEVPSVIVLTN
>NZ_AP022584.1|WP_067166482.1|4227561_4228083_+|hypothetical-protein
MSETPEPQAEPTPAAAATAPPPPPPQRVKPPRLYTAAAWVVIVAGIVFIISSVFFVGAFIWKHHYHCHHHHHGMFHPGGPGPGNGPWQYGNPGPGNGPWQNGPGGPGPWYGGPGGPGPDNGPWGPGPGGPGLIVPMPPGGPGGPGGPVSGPGISGPGQPTVVSPAPGTPAPRP
>NZ_AP022584.1|WP_067166502.1|4228211_4228874_+|sensor-domain-containing-protein
MTMRATQVHRAVLAVGFALAGTIAPAVAAAHPSEPGVVNYAVLGKGSVGNIVGGPMGWESVFTQPGQGLWVDLPECNNWADVGLSEVYDDPDLASFNGAVTQTSASDQTHLVKQAVGVFATTDAAARAFHRVVDRTAGCSGQTTAIHLDNGSTQVWSFDGGPAGPADENWTKQEAGTDRRCFDQTRLRENVLLQAKVCQSGNAGPAVNVLAGAMQNALGQ
>NZ_AP022584.1|WP_083016565.1|4229052_4230363_+|ergothioneine-biosynthesis-glutamate--cysteine-ligase-EgtA
MTFAPITAADPRSTGADPAPELKVAELTDSAAVAQYIAEGCLVDAPLGRVGLELEAHCHDPAAPHRRPGWGEIAAVLDALPPLPGGSRVTVEPGGAVELSGPPADGVLPAIDAMQRDQAVLQPAFAEAGLGLVFLGADPLRSPQRINPGPRYRAMEQFFATSRSGEAGAAMMTSTASIQVNIDAGPREGWAARVRLAHALGPTMIAITANSPMLAGDFTGWASSRQRVWGQMDSARCGPILGTSGDDPGIDWARYALKAPVMLVHTPDAEAVTHWVPFADWVDGRALLGDRRPSVADLEYHLTTLFPPVRPRQWLEIRYLDSVPDALWPAVVFTLVALLDDPVAADAAAAAVESVATAWDVAARAGLRDPRLYAAANACVTIAAERAPAELGDAMQRLIRLVEQGRCPGDDFADQVIKHGVTAEVSRLARSAQGGL

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Crispr_ID: NZ_AP022584_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022584_4

5405394-5405474

Orphan

Consensus_repeat	Method
GCGGCGGAGCCGGGCGCGGCGGGTCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022584_4

>merge|NZ_AP022584|4|5405394-5405474|CRISPRCasFinder
GCGGCGGAGCCGGGCGCGGCGGGTCGTCACCATCGGGCTAGTGGCGATCGCAAGTGCGGCGGAGCCGGGCGCGGCGGGTCG

>NZ_AP022584|4|4|5405394-5405474|CRISPRCasFinder
GCGGCGGAGCCGGGCGCGGCGGGTCG	TCACCATCGGGCTAGTGGCGATCGCAAGT
GCGGCGGAGCCGGGCGCGGCGGGTCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022584.1\|WP_083015415.1\|5397948_5399187_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|234945
NZ_AP022584.1\|WP_067171101.1\|5416450_5417272_+\|CoA-ester-lyase	unknown	unknown	gnl\|CDD\|225184
NZ_AP022584.1\|WP_083015424.1\|5407243_5408050_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223377
NZ_AP022584.1\|WP_083015596.1\|5401823_5402726_+\|DMT-family-transporter	unknown	unknown	unknown
NZ_AP022584.1\|WP_083015409.1\|5394646_5395120_-\|thioredoxin-dependent-thiol-peroxidase	unknown	unknown	gnl\|CDD\|224146
NZ_AP022584.1\|WP_067171248.1\|5411192_5412782_+\|methylcrotonoyl-CoA-carboxylase	unknown	unknown	gnl\|CDD\|178415
NZ_AP022584.1\|WP_083015434.1\|5412787_5414785_+\|acetyl/propionyl/methylcrotonyl-CoA-carboxylase-subunit-alpha	unknown	unknown	gnl\|CDD\|227111
NZ_AP022584.1\|WP_067171075.1\|5404717_5405365_-\|oligoribonuclease	unknown	unknown	gnl\|CDD\|235429
NZ_AP022584.1\|WP_083015600.1\|5402896_5404093_+\|L,D-transpeptidase-family-protein	unknown	unknown	gnl\|CDD\|380079
NZ_AP022584.1\|WP_067171096.1\|5414781_5415948_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173847
NZ_AP022584.1\|WP_083015430.1\|5410340_5410997_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_AP022584.1\|WP_083015418.1\|5399382_5401749_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_AP022584.1\|WP_083015593.1\|5395224_5395452_+\|DUF3618-domain-containing-protein	unknown	unknown	gnl\|CDD\|378834
NZ_AP022584.1\|WP_067171072.1\|5404102_5404477_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022584.1\|WP_067171099.1\|5415944_5416454_+\|MaoC-family-dehydratase	unknown	unknown	gnl\|CDD\|239535
NZ_AP022584.1\|WP_083015421.1\|5405565_5407131_+\|DUF853-family-protein	unknown	unknown	gnl\|CDD\|283518
NZ_AP022584.1\|WP_067171063.1\|5395438_5397178_-\|DUF3556-domain-containing-protein	unknown	unknown	gnl\|CDD\|371888
NZ_AP022584.1\|WP_169925506.1\|5409497_5410271_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223021
NZ_AP022584.1\|WP_083015412.1\|5397285_5397552_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022584.1\|WP_067171083.1\|5408119_5409472_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|225179

Protein	Function_ID	Function_description	E-value
NZ_AP022584.1\|WP_083015415.1\|5397948_5399187_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|234945	PRK01346, PRK01346, enhanced intracellular survival protein Eis.	7.45181e-161
NZ_AP022584.1\|WP_067171101.1\|5416450_5417272_+\|CoA-ester-lyase	gnl\|CDD\|225184	COG2301, CitE, Citrate lyase beta subunit [Carbohydrate transport and metabolism].	1.25038e-75
NZ_AP022584.1\|WP_067171083.1\|5408119_5409472_+\|MFS-transporter	gnl\|CDD\|225179	COG2270, COG2270, Permeases of the major facilitator superfamily [General function prediction only].	1.65703e-131
NZ_AP022584.1\|WP_083015424.1\|5407243_5408050_-\|SDR-family-oxidoreductase	gnl\|CDD\|223377	COG0300, DltE, Short-chain dehydrogenases of various substrate specificities [General function prediction only].	1.23321e-102
NZ_AP022584.1\|WP_083015409.1\|5394646_5395120_-\|thioredoxin-dependent-thiol-peroxidase	gnl\|CDD\|224146	COG1225, Bcp, Peroxiredoxin [Posttranslational modification, protein turnover, chaperones].	2.27519e-76
NZ_AP022584.1\|WP_083015434.1\|5412787_5414785_+\|acetyl/propionyl/methylcrotonyl-CoA-carboxylase-subunit-alpha	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NZ_AP022584.1\|WP_067171075.1\|5404717_5405365_-\|oligoribonuclease	gnl\|CDD\|235429	PRK05359, PRK05359, oligoribonuclease; Provisional.	2.03342e-118
NZ_AP022584.1\|WP_083015600.1\|5402896_5404093_+\|L,D-transpeptidase-family-protein	gnl\|CDD\|380079	pfam17964, Big_10, Bacterial Ig domain. This entry represents a bacterial Ig-like domain found associated with transpeptidase domains.	2.57482e-77
NZ_AP022584.1\|WP_083015430.1\|5410340_5410997_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.50381e-14
NZ_AP022584.1\|WP_067171248.1\|5411192_5412782_+\|methylcrotonoyl-CoA-carboxylase	gnl\|CDD\|178415	PLN02820, PLN02820, 3-methylcrotonyl-CoA carboxylase, beta chain.	0
NZ_AP022584.1\|WP_083015593.1\|5395224_5395452_+\|DUF3618-domain-containing-protein	gnl\|CDD\|378834	pfam12277, DUF3618, Protein of unknown function (DUF3618). This domain family is found in bacteria, and is approximately 50 amino acids in length.	3.4246e-11
NZ_AP022584.1\|WP_067171099.1\|5415944_5416454_+\|MaoC-family-dehydratase	gnl\|CDD\|239535	cd03451, FkbR2, FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The function of FkbR2 is unknown.	4.06402e-72
NZ_AP022584.1\|WP_083015421.1\|5405565_5407131_+\|DUF853-family-protein	gnl\|CDD\|283518	pfam05872, DUF853, Bacterial protein of unknown function (DUF853). This family consists of several bacterial proteins of unknown function. BMEI1370 is thought to be an ATPase.	0
NZ_AP022584.1\|WP_067171063.1\|5395438_5397178_-\|DUF3556-domain-containing-protein	gnl\|CDD\|371888	pfam12077, DUF3556, Transmembrane protein of unknown function (DUF3556). This family of transmembrane proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 576 to 592 amino acids in length.	0
NZ_AP022584.1\|WP_169925506.1\|5409497_5410271_-\|hypothetical-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	0.0005739
NZ_AP022584.1\|WP_083015418.1\|5399382_5401749_+\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	6.14738e-105
NZ_AP022584.1\|WP_067171096.1\|5414781_5415948_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	1.44108e-157

>NZ_AP022584.1|WP_067171075.1|5404717_5405365_-|oligoribonuclease
MRDELVWIDCEMTGLDLGSDKLIEIAALVTDADLNILGDGVDVVIHADDAALEAMGDVVTEMHSRSGLIDEVRASAVDLATAEAMVLDYIGQHVKQPKTAPLAGNSIATDRAFIVRDMPALDTYLHYRMIDVSSIKELCRRWYPRIYFGQPAKGLAHRALADIHESIRELQFYRRTAFVSPPGPSTSEIEAVVTSLDGGKDAPGPSDSASAPPSR
>NZ_AP022584.1|WP_067171072.1|5404102_5404477_-|hypothetical-protein
MATAAAAVALMLAGCGGSSHTATTVISTPPAETKTVTKTVAPPPPPGPKTSIEANGTYIVNKDIAAGTYRTDGGKYGCYWARLRSFDTNDIIDNNVGDGPQVVRILPTDTAFMTRSCGSWHKID
>NZ_AP022584.1|WP_083015600.1|5402896_5404093_+|L,D-transpeptidase-family-protein
MTPLRGRRLWLAAAIAAIAVFAVGCGGNHAAAPAKVIFDKGTPFADLLVPKLTSSVTDGAVGVTVDAPVTVSVADGVLASVTIVNENGRSISGKLSPDGLRWSTTEQLGYNRRYTLTVKATGLGGAASKQMTFATSSPAHLTMPYVSPADGEVVGIGEPVAIRFDENIADRAAAQKAITITTNPPVDGAFYWLTNREVRWRPEHFWKSGTAIDVAVNTYGVDLGDGMFGEDNVKTHFAIGDEVISTADDTTKTVTVRVNGEVVKTMPTSMGKDSTPTANGVYIIGARFKHMIMDSSTYGVPVNSPNGYRTEVDWATQMSYSGVFVHSAPWSVGAQGHTNTSHGCLNVSPSNAEWFYDHSKSGDIVEVVHTVGPTLPGIEGLGDWNIPWPEWKAGNANT
>NZ_AP022584.1|WP_083015596.1|5401823_5402726_+|DMT-family-transporter
MGRTDIAALLALSSALCVAVGDVLQQRAAHCITDRAVGSVELFANLLRSQRWWWGTVLLAASIGLQAAALAGGSVLLVQALLMFSVLFALPINARLWHRTVTAGEWTWAALLTAGVSVVVIVGNPRAGHSGASLGTWAAVAAVLGPLLVGCAVAGRIRGGAVAAVLFAFVSGSLWGIFAVLTKEVVARLGDGVGALTRTPELYACILVALGGVAWSQSAFRAGPLTASMPTLQMSQPVVAAVLGVVVLGEVLDTGRTGMIALVAAALVMTAAIIKLARVEAVATRDGVEARRHEEAGQPA
>NZ_AP022584.1|WP_083015418.1|5399382_5401749_+|MMPL-family-transporter
MLQVITRLAIAAPRRIVGIAFLVLVGAAVFGLPVVNSLSGGGFQDPTSESARATEVLRDKFNQTDQQMLIVVTAPNGVRSDQARRVATDIVDQLKRSPWVLNVSSAWTMPPDRAPAAAQLISKDNKSGMIVAGLKGGENDAQKYASTLTSDLVHDRDGVTVRAGGMAVAYAQINGQNQRDLLLMESIAIPLSFAVLVWVLGGVVAATLPIVLGLLAIVGTMSVLRLITFATDVSTYALDLSIAMGLALAIDYNLLIITRYREELARTEDRDRALYRTMATAGRTVLFSATTVGLSMAVMALFPMYFLKSSAYTIVVTAIIVAIAAVVVTPAAIVLLGPRLHVLDARRVMHRILHGQRSFRDHAHQPLEEQFWYRSTRYVLGDAMPVGLSVVALLVLLGAPFLGVKWGFPDERVLPESASARQVADMLDDDFANGFGTGVSVVVPDTRGVSPADLQRYAAELSRVPDVSAVSAPAGTFADGNRVGPPVGPTGVANGSAFLTVSTTAPLYSQASNTQLDRLHQVAGPGGRSVQMTGLAQINRDSVDAITNRLPIVFALIALITFALLFLLTGSAVLPLQALVCNVLSLTAAFGAMVWIFQDGNLGALGTTPNGTLNANIPVLLFCIAFGLAMDYEVFLVSRIHEYWLASQAMRETPPTAAEARAATDESTALGIAGIGRVVTTAAVVMSISFAALIPAHVSFMRMLGLGLTLGVLVDATLVRMVLVPAFLHLMGRWTWWAPRPLVRLRERSAIGEDGEIAVGRGRWARDAPNVGRALIRRWPTKAATGRG
>NZ_AP022584.1|WP_083015415.1|5397948_5399187_-|GNAT-family-N-acetyltransferase
MNTTDDGTNIRHPTENDWQAVFENQARTFGDPVGPEDLEAWKRRVNLDDILLAEDVSDPERPFLVGTSIIYRAQLTVPGGATLRAAWLTMIAVAATHQGKGLWAQLSAKGLGILLDRGYPLVCGVPTQTAMYDGFGAGVASYSHTYSIDRRFAKLRAAPDGIRAREVNAAEARRHLPEIYERWCAATNGAISRGDAWWTDYMDDRETQRGNGSALQYTIHPDGFLTYRVVGSQQHAFRPPLGTVVVEDFCPVTDEAHTELLQTLLVLEMFYRIEIDVPGDDPLPLKLTDQRAAEIKGVSDFLWVRINDVPEVLGARAYADDADIVLEVTDPLQLAGGRFQLQARGGAGKCTPTDGPADIEIGLADLATIYMGAHRASQLARAGRITEARAGALAELDAAFATDRAPFCGTVL
>NZ_AP022584.1|WP_083015412.1|5397285_5397552_-|hypothetical-protein
MKTELKWVEPHEGHFHANIDDRSEYRVHAVSTGGFRAERVDDGLVHHDLGRAAGAAEAQAICQDLHTRAMRRAAWETYMAENDPPGRE
>NZ_AP022584.1|WP_067171063.1|5395438_5397178_-|DUF3556-domain-containing-protein
MGFIRPNLPVVDVADWSARPRAERIVPMARHIAQHGFGTPLVMHVMYGVKIALYILGGWLFVWSTRGIGGFTQVSAWWAEPIVFQKAVLYTMLFEVVGLGCCFGPLAGRYFPPMGSILYWLRPGTIRLPPWPDRVPLTKGGNRTPLDALLYGVLLVLLVFALLSDGTGPIPALDTAIGVLPRWQTAAVLAVLALISLRDKVIFLAARGEVYAPLALTFLFAGADIIVGAKVVFMVIWLGAATSKLNKHFPFVISTMLANNPFIPSGPLKRSMFKRYPDDLRPSALAGFIAHFSTAVEGLVPLVLLFSHGGWPTALAAFVMIVFHLNILLAFPMGVPLEWNVFMIFGVLWLFVTHAHLGLSNISNPWPIALLFAVIAGTVVAGNLYPRKVSFLPGMRYYAGNWDTTLWCVRPSADEKFRIGSRALGPMQHLQLERLYGSKEETLVPLHLALAFRGMNTHGRALLTLAHRAMADYDEDDYNLCEGEVLCSMVLGWNFGDGHMHNECLIEALQQRCGFEPGEVRVVILDAQPIHRQRQEYRLVDAATGEFERGYCDVADMVVNQPWADDIPVYVQSDRVSGS
>NZ_AP022584.1|WP_083015593.1|5395224_5395452_+|DUF3618-domain-containing-protein
MADRDPEAIKRDIDVARDQLAATVDSLAERANPRRLADDLKARVIGFVQKPVVLASLAGVGALVVVVTVHRVRNR
>NZ_AP022584.1|WP_083015409.1|5394646_5395120_-|thioredoxin-dependent-thiol-peroxidase
MTETTRLAPGDKAPSFSLPDADGNKVSLADYKGRRVVVYFYPAASTPGCTKQACDFRDNLAELNGAGLDVVGISPDKPEKLAKFRDAEGLTFPLLSDPDRKVLTAYGAYGEKQMYGKTVTGVIRSTFVVDEKGKIAVAQYNVKATGHVAKLRRDLSV
>NZ_AP022584.1|WP_083015421.1|5405565_5407131_+|DUF853-family-protein
MSTDSAATPASRIADGYAVDGQALELGTVVVDGAADPTAQIRIPLATVNRHGLVAGATGTGKTKTLQLIAEQLSAAGVPVLMADVKGDLSGLSAVGEGNDKTAARARDTGDDWTGTGFPVEFLSLGTGGIGVPVRATVDSFGPVLLSKVLGLNATQESTLGLIFHWAKERSYQLVTLANLRDAITHLTSEEGKADLKSLGGVSSTTAGVILRALVNLEGEGGDTFFGQPKLDPHDLLRVEGGRGIISLLEFGGQSLRPVIFSTFLMWLLADLFTVLDEVGDIDKPKLVFFFDEAHLLFADASKAFLEQVEQTVKLIRSKGVGVFFCTQLPTDLPNDVLSQLGARIQHALRAFTPDDQKALSKTVRTYPKTDVYDLESALTSLGIGEAVVTVLSEKGAPTPVAWTRMRVPRSLMASIGNDAIKAAAKDSALQAKYGHTAEQPAQPQDVHPPSQPPQAQSDYPPVPPNDPVPPMPEPAEPKGAKGPSMWEEVLQNPTVKSGINTAIREAVRSIFGSGSRRRRK
>NZ_AP022584.1|WP_083015424.1|5407243_5408050_-|SDR-family-oxidoreductase
MPIPAPSPEARAVVTGASQNIGEALATELAARGHNLIVTARREDLLKDLAARLAAQHHVTVDVRPADLADPGDRAKLCDELAARPISILCANAGTATFGPVATLDPAGEKAQLQLNVLGVHDLTLAVLPGMVERGAGGVLISGSAAGNSPIPYNATYAATKAFVNTFTESLRGELRGSGVNVTLLAPGPVRTDLPADTEASIVERLVPDFLWISTEHTARVSLDALGRNKMRVVPGLTSKAMSVASGYAPRAIVAPIVGAFYKKLGGG
>NZ_AP022584.1|WP_067171083.1|5408119_5409472_+|MFS-transporter
MSQPELRSAAPVRSRVVAWALWDCGSTGLNAIVATFVFAVYLTSSVGVGIGGSTTPASWLGRAAAIAGLTVAILAPAVGVWVESPHRRRVALSVLTAAAVTLTSLMFFIRDRPGYLWAGLVLLGATAACGDLASVPYNAMLRQLSTPQTAGRISGFGWAAGYGGSVLLLLVIYTGFISGSDSGQGATRGLLRIPLQDGLYVREAMLVAAAWLAVFALPLLFVAQRLSDPAEAYQPTSMLGGYRKLWSEVSAEWRRDRNLVYFLIASALFRDGLAAIFAFGAVLGVNVYGISQADVLIFGVAACVVAAVGAVLGGFVDHRAGSKPVIVASLVAIITLGLTLMASSGPVAFWVCGLLLCMFIGPTQSSSRALLLQMAKHGREGVAFGLYTMTGRAVAFLAPWLFSVFVDVFGAVRAGLGGISLVLIAGLVAMLGVRVPQRGVSVTEPVAEPS
>NZ_AP022584.1|WP_169925506.1|5409497_5410271_-|hypothetical-protein
MNDSRPTERFGPSLPGPQQRGYAPPADPAYADQTPYAPAYGGTTSPWAPTANETNTTKRLPAYWRQDLPPSDDPHAQGMAPPPPGGPKSPRWLWIAAGAAVLLVVALVIALALANDAIKTQTAVPPLPAMPEPSPESPTTSARQSPTLIPAPIPPTSGTQLPGPTTGPAAMQDVVYTVTGEGRAISIMYIDTGDLIQTEFNVAMPWSKQVSLAKSATHPANVTIVNIGHSVTCTVTVDGVQVSKRVGGGLTICDARG
>NZ_AP022584.1|WP_083015430.1|5410340_5410997_-|TetR-family-transcriptional-regulator
MTTSASEGQAAGADTPNRRSQLKSDRRLQLLSAAERLFAERGFLAVRLEDIGAAAGVSGPAIYRHFPNKESLLVELLVGISTRLLAGARQVRAHSSDAAAALDGLIDFHLDFALTEPDLIRIQDRDLAYLPGAAEKQVRKAQRQYVEVWVGVLRELSPELAEADARLTAHAVFGLLNSTPHSMKSADTSRSKSVRAARSRAVMRAMTIAALAAGNQCP
>NZ_AP022584.1|WP_067171248.1|5411192_5412782_+|methylcrotonoyl-CoA-carboxylase
MTSPAKAPEASFADEHRRLVGELNTRLAAAALGGNERARERHVSRGKLLPRERVDRLLDPGSPFLELSPLAADGMYDDESPGAGIITGIGRVSERECVIVANDATVKGGTYYPMTVKKHLRAQEVALQNRLPCIYLVDSGGAFLPRQDEVFPDREHFGRIFFNQATMSAKGIPQVAAVLGSCTAGGAYVPAMSDEAVIVREQGTIFLGGPPLVKAATGEIVSAEDLGGGDLHSRVSGVTDHLADDDEHALRIVRSIAATFGPREPGPWEVRSPVPPMCAQTELYDVVPPDPRVPYDVHEVIVRLVDGGEFSEFKANYGKTLVTAFAHIHGHPVGIVANNGVLFSESALKGAHFIELCDKRKIPLLFLQNIAGFMVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRGEQLSAAGKPWSADEEEAFKAPIRGQYEDQGNPYYSTARLWDDGIIDPADTRTFVGLALSVCAQAPLEPVSYGVFRM
>NZ_AP022584.1|WP_083015434.1|5412787_5414785_+|acetyl/propionyl/methylcrotonyl-CoA-carboxylase-subunit-alpha
MFETVLVANRGEIAVRVIRTLRRLGIRSVAVYSDPDAGARHVLEADEAVRLGPAAARESYLNIDKVVDAAVRTGSQAIHPGYGFLSENADFAAACERAGVVFLGPPAQAIQVMGDKITAKNAVAAFDVPVVPGVAKPGLSDDALVAAADEVGYPVLIKPSAGGGGKGMRLVEEPAKLREALVSARREAASAFGDDTLFLERFVLRPRHIEVQVLADTHGNVVHLGERECSLQRRHQKVIEEAPSPLLDEVTRARIGAAACNTARSVDYVGAGTVEFIVSADRAQEFFFMEMNTRLQVEHPVTEAVTGLDLVEWQLRVAAGEKLTFAQDDIELRGHAIEARVYAEDPARGFLPTGGRVLGVFEPSGDGVRVDSSLLPGTVVGSDYDPMLSKVIAYGADRDEALEKLDRALSHTAILGVQTNIEFLRFLLADERVRAGDLDTALLDERLADFAPLPAPDDVLAAAGLYRQSALASRARHFAGNPWAAPTGWRVGGSAAPVRTDMRTPLRSETVSVWGLPESATVQVGDGETCSAAVHVEPARMSAVIDGLRRDYRWAEADRHLWIADERGTWHLREAEENKIHRAAGAQRAEILSPMPGSVIAVQTASGTEVSEGDVVVVVEAMKMEHSLAAPVSGQVEVLVSVGDQVTVDQVLARLIPEEESKDET
>NZ_AP022584.1|WP_067171096.1|5414781_5415948_+|acyl-CoA-dehydrogenase-family-protein
MTTSITAGALPKEYEDLRDTVAEFARTVVAPVSAKHDEEHSFPYEVVAKMGEMGLFGLPFPEEYGGMGGDYFALSLALEELGKVDQSVAITLEAGVGLGAMPIYRFGTEEQKQKWLPDLTAGRALAGFGLTEPGAGSDAGGTRTTARLDNDEWVINGSKQFITNSGTDITSLVTVTAVTGTVGADKKEISTIIVPSGTPGFTVEPVYSKVGWNASDTHPLSFADARVAEENLLGERGRGYANFLSILDEGRIAIAALSTGAAQGCVDESVKYSKERQSFGQPIGSYQAISFKIARMEARAHVARTAYYDAAAKMLAGKPFKKEAAIAKMIASEAAMDNARDATQIHGGYGFMNEYPVARHYRDSKILEIGEGTTEVQLMLIARSLGLS
>NZ_AP022584.1|WP_067171099.1|5415944_5416454_+|MaoC-family-dehydratase
MSAPDQAGKSVEQRGLWFEEFEIGTTYLHRPGRTVTEADNVLFTTLTMNTQSLHLDAAWAAEQPGFRGERLVNSMFTLSTVVGLSVSQLTLGTIVANLGFSEVSFPKPVFHGDTLYAETVCTAKRESKSRPGEGIVTLEHTGRNQHGDVVARAARTTLVQKRPADQEAQ
>NZ_AP022584.1|WP_067171101.1|5416450_5417272_+|CoA-ester-lyase
MNLHAAGPGWLFCPADRPERFAKAAAAADVVILDLEDGVAEADKPAARKALQETPLDPERTVVRINAADTAEYPRDLEALAGTAYTTVMLSKTESAAQVEALAPRDVIALLETPRGAVFATEISAAPGTVALMWGAEDLVATLGGSSSRWADGTYRDVAHHVRSTALLNASTFGRLALDAVHLDIRDLDGLRAEAQDAVALGFGGTVCIHPSQIPVVREAYRPSEDRLDWARRVLVAARSERGVFAFEGQMVDSPVLKHAQMTLRRAGETLPG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_AP022584_2	2.1\|1458141\|37\|NZ_AP022584\|CRISPRCasFinder	1458141-1458177	37	NZ_AP022584.1	1458285-1458321	1	0.973

1. spacer 2.1|1458141|37|NZ_AP022584|CRISPRCasFinder matches to position: 1458285-1458321, mismatch: 1, identity: 0.973

agctcgagctcctcggcctcggattcctcggcttcgg	CRISPR spacer
agctcgagctcctcggcctcggattcctccgcttcgg	Protospacer
***************************** *******

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP022584_2	2.2\|1458201\|34\|NZ_AP022584\|CRISPRCasFinder	1458201-1458234	34	NZ_CP010856	Marinovum algicola DG 898 plasmid pMaD1, complete sequence	75787-75820	8	0.765
NZ_AP022584_4	4.1\|5405420\|29\|NZ_AP022584\|CRISPRCasFinder	5405420-5405448	29	NC_018583	Gordonia sp. KTR9 plasmid pGKT3, complete sequence	6205-6233	8	0.724
NZ_AP022584_4	4.1\|5405420\|29\|NZ_AP022584\|CRISPRCasFinder	5405420-5405448	29	NZ_CP047236	Gordonia sp. JH63 plasmid pJH63-1, complete sequence	151760-151788	8	0.724
NZ_AP022584_4	4.1\|5405420\|29\|NZ_AP022584\|CRISPRCasFinder	5405420-5405448	29	NZ_CP029833	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed3, complete sequence	319937-319965	8	0.724
NZ_AP022584_2	2.2\|1458201\|34\|NZ_AP022584\|CRISPRCasFinder	1458201-1458234	34	NZ_CP045548	Streptomyces sp. SYP-A7193 plasmid unnamed1, complete sequence	154641-154674	9	0.735
NZ_AP022584_2	2.2\|1458201\|34\|NZ_AP022584\|CRISPRCasFinder	1458201-1458234	34	NZ_CP049030	Fluviibacterium aquatile strain SC52 plasmid pSC52_2, complete sequence	285244-285277	9	0.735
NZ_AP022584_2	2.2\|1458201\|34\|NZ_AP022584\|CRISPRCasFinder	1458201-1458234	34	NC_022125	Rhodococcus erythropolis CCM2595 plasmid pRECF1, complete sequence	77395-77428	10	0.706
NZ_AP022584_2	2.2\|1458201\|34\|NZ_AP022584\|CRISPRCasFinder	1458201-1458234	34	NZ_CP034156	Rhodococcus sp. NJ-530 plasmid unnamed4, complete sequence	19850-19883	10	0.706

1. spacer 2.2|1458201|34|NZ_AP022584|CRISPRCasFinder matches to NZ_CP010856 (Marinovum algicola DG 898 plasmid pMaD1, complete sequence) position: , mismatch: 8, identity: 0.765

tccggctcgccggactcatcgacgac-cgcctgtt	CRISPR spacer
accggctcgtcgggctcatcgacgacatggatga-	Protospacer
 ********.***.************ .*  **

2. spacer 4.1|5405420|29|NZ_AP022584|CRISPRCasFinder matches to NC_018583 (Gordonia sp. KTR9 plasmid pGKT3, complete sequence) position: , mismatch: 8, identity: 0.724

tcaccatcgggctagtggcgatcgcaagt	CRISPR spacer
cggtcatggggctagtggcgatcgcagtc	Protospacer
. ..*** ******************. .

3. spacer 4.1|5405420|29|NZ_AP022584|CRISPRCasFinder matches to NZ_CP047236 (Gordonia sp. JH63 plasmid pJH63-1, complete sequence) position: , mismatch: 8, identity: 0.724

tcaccatcgggctagtggcgatcgcaagt	CRISPR spacer
cggtcatggggctagtggcgatcgcagtc	Protospacer
. ..*** ******************. .

4. spacer 4.1|5405420|29|NZ_AP022584|CRISPRCasFinder matches to NZ_CP029833 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.724

tcaccatcgggctagtggcgatcgcaagt	CRISPR spacer
cgaccatcgggctggtgtcgatcgcgctg	Protospacer
. ***********.*** *******.

5. spacer 2.2|1458201|34|NZ_AP022584|CRISPRCasFinder matches to NZ_CP045548 (Streptomyces sp. SYP-A7193 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.735

tccggctcgccggactcatcgacgaccgcctgtt	CRISPR spacer
cgcacgccgccggactcatcgccgaccacctgct	Protospacer
. *.  .************** *****.****.*

6. spacer 2.2|1458201|34|NZ_AP022584|CRISPRCasFinder matches to NZ_CP049030 (Fluviibacterium aquatile strain SC52 plasmid pSC52_2, complete sequence) position: , mismatch: 9, identity: 0.735

tccggctcgccggactcatcgacgaccgcctgtt	CRISPR spacer
ccgggctcgccggacggatcgacgacccgcttcg	Protospacer
.* ************  **********  ** .

7. spacer 2.2|1458201|34|NZ_AP022584|CRISPRCasFinder matches to NC_022125 (Rhodococcus erythropolis CCM2595 plasmid pRECF1, complete sequence) position: , mismatch: 10, identity: 0.706

tccggctcgccggactcatcgacgaccgcctgtt	CRISPR spacer
ccccaagtgccggacgcatcgacgacggcctgag	Protospacer
.** .  .******* ********** *****

8. spacer 2.2|1458201|34|NZ_AP022584|CRISPRCasFinder matches to NZ_CP034156 (Rhodococcus sp. NJ-530 plasmid unnamed4, complete sequence) position: , mismatch: 10, identity: 0.706

tccggctcgccggactcatcgacgaccgcctgtt	CRISPR spacer
ccccaagtgccggacgcatcgacgacggcctgag	Protospacer
.** .  .******* ********** *****

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1608294 : 1617456

Shahe_endorna-like_virus(50.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_083018218.1\|1608294_1609551_+	glycosyltransferase	A0A1L3KK54	Shahe_endorna-like_virus	9.5e-06	34.2
WP_083018220.1\|1609558_1610338_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_169925524.1\|1610477_1611281_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_083018224.1\|1611395_1612202_-	class I SAM-dependent methyltransferase	A0A2R8FFV8	Cedratvirus	1.2e-54	50.0
WP_083018226.1\|1612299_1613586_-	glycosyltransferase	A0A1L3KK54	Shahe_endorna-like_virus	1.2e-08	44.4
WP_083018294.1\|1614002_1615271_-	glycosyltransferase	A0A1L3KK54	Shahe_endorna-like_virus	7.3e-06	38.7
WP_083018296.1\|1615389_1616196_-	class I SAM-dependent methyltransferase	A0A2R8FDY2	Brazilian_cedratvirus	7.1e-55	52.6
WP_083018228.1\|1616346_1617456_-	NAD-dependent epimerase/dehydratase family protein	M1I1Z9	Acanthocystis_turfacea_Chlorella_virus	2.5e-18	25.0

DBSCAN-SWA_2

2376285 : 2383364

Bacillus_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_083018951.1\|2376285_2376753_+	VOC family protein	A0A2K9L121	Tupanvirus	3.9e-13	33.8
WP_067175097.1\|2376780_2378946_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	V9VI16	Lactococcus_phage	1.9e-208	51.6
WP_067175094.1\|2378915_2379368_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A142F1R4	Bacillus_phage	7.6e-14	39.3
WP_064936759.1\|2379400_2379640_-	redoxin NrdH	V5UN81	Mycobacterium_phage	2.6e-21	64.5
WP_083018890.1\|2380167_2380722_-	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	1.6e-05	34.4
WP_067175190.1\|2381435_2382488_+	DNA polymerase IV	F1C5A5	Cronobacter_phage	7.1e-23	29.6
WP_083018888.1\|2382422_2383364_-	SDR family oxidoreductase	W8CYX9	Bacillus_phage	9.3e-06	29.5

DBSCAN-SWA_3

2943748 : 2952518

Burkholderia_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_067171975.1\|2943748_2945275_+	cyclic nucleotide-binding domain-containing protein	W8CYF6	Bacillus_phage	2.2e-12	36.6
WP_067171977.1\|2945314_2946163_+	LLM class F420-dependent oxidoreductase	NA	NA	NA	NA
WP_067171978.1\|2946183_2947062_+	LLM class F420-dependent oxidoreductase	NA	NA	NA	NA
WP_067171980.1\|2947089_2948085_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	2.9e-74	46.2
WP_067172042.1\|2948086_2948704_+	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	4.8e-27	38.8
WP_067171981.1\|2948943_2950065_+	acyltransferase	A9YX16	Burkholderia_phage	2.6e-15	27.3
WP_083019704.1\|2950191_2951328_+	acyltransferase	A9YX16	Burkholderia_phage	7.5e-18	28.3
WP_067172044.1\|2951429_2952518_+	acyltransferase	A9YX16	Burkholderia_phage	8.4e-19	30.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_AP022584

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection