CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_AP022590	Mycobacterium mantenii strain JCM 18113	13 crisprs	csa3,cas3,WYL,cas4,DEDDh,DinG	10	10	1	0

1. NZ_AP022590

CRISPR-Cas detection and classification

Crispr_ID: NZ_AP022590_1

• CRISPR_ID: NZ_AP022590_1
• CRISPR_location: 30848-30928
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP022590_1

Consensus_repeat	Method
GGCGAAGGGGGTCGCCACGATCCG	CRISPRCasFinder

spacers of NZ_AP022590_1

>1.1|30872|33|NZ_AP022590|CRISPRCasFinder
GCCAGCGTGGCGATCGTGAGCGCGGCGGCGCCA

CRISPR arrays and Neighbor proteins around NZ_AP022590_1

CRISPR arrays

The CRISPR arrays of NZ_AP022590_1

>merge|NZ_AP022590|1|30848-30928|CRISPRCasFinder
GGCGAAGGGGGTCGCCACGATCCGGCCAGCGTGGCGATCGTGAGCGCGGCGGCGCCAGGCGAAGGGGGTCGCCACGATCCG

>NZ_AP022590|1|1|30848-30928|CRISPRCasFinder
GGCGAAGGGGGTCGCCACGATCCG	GCCAGCGTGGCGATCGTGAGCGCGGCGGCGCCA
GGCGAAGGGGGTCGCCACGATCCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022590.1|WP_163650933.1|40152_41247_-|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl|CDD|224437
NZ_AP022590.1|WP_083092738.1|27437_27698_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083092729.1|35210_36041_+|NUDIX-domain-containing-protein	unknown	unknown	gnl|CDD|239518
NZ_AP022590.1|WP_083092749.1|22144_22882_-|hypothetical-protein	unknown	unknown	gnl|CDD|237862
NZ_AP022590.1|WP_083092721.1|42333_42762_-|DUF4333-domain-containing-protein	unknown	unknown	gnl|CDD|379513
NZ_AP022590.1|WP_083092742.1|25915_26245_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_169926937.1|37891_38971_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|380115
NZ_AP022590.1|WP_083092734.1|29696_30794_-|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|238566
NZ_AP022590.1|WP_064952277.1|41599_42337_+|acetyltransferase	unknown	unknown	gnl|CDD|100053
NZ_AP022590.1|WP_163650789.1|31141_32827_+|cytochrome-c-oxidase-subunit-I	unknown	unknown	gnl|CDD|238832
NZ_AP022590.1|WP_083093109.1|23072_23444_-|DUF4189-domain-containing-protein	unknown	unknown	gnl|CDD|372741
NZ_AP022590.1|WP_163650788.1|26241_26784_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_158086040.1|23764_24484_-|DUF732-domain-containing-protein	unknown	unknown	gnl|CDD|368380
NZ_AP022590.1|WP_158086039.1|27250_27388_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083092723.1|39744_40134_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083092725.1|36812_37784_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|369777
NZ_AP022590.1|WP_083092735.1|28536_29577_-|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl|CDD|176186
NZ_AP022590.1|WP_142275406.1|36037_36802_+|enoyl-CoA-hydratase	unknown	unknown	gnl|CDD|235632
NZ_AP022590.1|WP_083092724.1|39041_39722_+|DUF3298-domain-containing-protein	unknown	unknown	gnl|CDD|378702
NZ_AP022590.1|WP_083092745.1|24476_24695_-|hypothetical-protein	unknown	unknown	gnl|CDD|237560

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP022590.1|WP_163650933.1|40152_41247_-|PQQ-binding-like-beta-propeller-repeat-protein	gnl|CDD|224437	COG1520, COG1520, FOG: WD40-like repeat [Function unknown].	2.30695e-22
NZ_AP022590.1|WP_083092729.1|35210_36041_+|NUDIX-domain-containing-protein	gnl|CDD|239518	cd03426, CoAse, Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative stress. CoAse has a conserved Nudix fold and requires a single divalent cation for catalysis. In addition to a signature Nudix motif G[X5]E[X7]REUXEEXGU, where U is Ile, Leu, or Val, CoAse contains an additional motif upstream called the NuCoA motif (LLTXT(SA)X3RX3GX3FPGG) which is postulated to be involved in CoA recognition. CoA plays a central role in lipid metabolism. It is involved in the initial steps of fatty acid sythesis in the cytosol, in the oxidation of fatty acids and the citric acid cycle in the mitochondria, and in the oxidation of long-chain fatty acids in peroxisomes. CoA has the important role of activating fatty acids for further modification into key biological signalling molecules.	0.000200644
NZ_AP022590.1|WP_083092749.1|22144_22882_-|hypothetical-protein	gnl|CDD|237862	PRK14948, PRK14948, DNA polymerase III subunit gamma/tau.	1.24073e-05
NZ_AP022590.1|WP_083092721.1|42333_42762_-|DUF4333-domain-containing-protein	gnl|CDD|379513	pfam14230, DUF4333, Domain of unknown function (DUF4333). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 140 and 255 amino acids in length. There are two completely conserved C residues that may be functionally important.	5.03611e-12
NZ_AP022590.1|WP_083092734.1|29696_30794_-|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl|CDD|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	3.15344e-59
NZ_AP022590.1|WP_064952277.1|41599_42337_+|acetyltransferase	gnl|CDD|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	6.25852e-34
NZ_AP022590.1|WP_169926937.1|37891_38971_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|380115	pfam18096, Thump_like, THUMP domain-like. This is a domain of unknown function found in bacteria.	9.27303e-14
NZ_AP022590.1|WP_083093109.1|23072_23444_-|DUF4189-domain-containing-protein	gnl|CDD|372741	pfam13827, DUF4189, Domain of unknown function (DUF4189). This domain of unknown function contains six well-conserved cysteine residues.	0.00783713
NZ_AP022590.1|WP_083092745.1|24476_24695_-|hypothetical-protein	gnl|CDD|237560	PRK13922, PRK13922, rod shape-determining protein MreC; Provisional.	0.00065343
NZ_AP022590.1|WP_158086040.1|23764_24484_-|DUF732-domain-containing-protein	gnl|CDD|368380	pfam05305, DUF732, Protein of unknown function (DUF732). This family consists of several uncharacterized Mycobacterium tuberculosis and leprae proteins of unknown function.	2.70907e-10
NZ_AP022590.1|WP_163650789.1|31141_32827_+|cytochrome-c-oxidase-subunit-I	gnl|CDD|238832	cd01662, Ubiquinol_Oxidase_I, Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits in ubiquinol oxidase varies from two to five. Subunit I contains a heme-copper binuclear center (the active site where O2 is reduced to water) formed by a high-spin heme and a copper ion. It also contains a low-spin heme, believed to participate in the transfer of electrons from ubiquinol to the binuclear center. For every reduction of an O2 molecule, eight protons are taken from the inside aqueous compartment and four electrons are taken from ubiquinol on the opposite side of the membrane. The four electrons and four of the protons are used in the reduction of O2; the four remaining protons are pumped across the membrane. This charge separation of four charges contributes to the electrochemical gradient used for ATP synthesis. Two proton channels, the D-pathway and K-pathway, leading to the binuclear center have been identified in subunit I. It is generally believed that the channels contain water molecules that act as 'proton wires' to transfer the protons. A well-defined pathway for the transfer of pumped protons beyond the binuclear center has not been identified. Electrons are believed to be transferred directly from ubiquinol (the electron donor) to the low-spin heme, and directly from the low-spin heme to the binuclear center.	0
NZ_AP022590.1|WP_083092735.1|28536_29577_-|NAD(P)-dependent-alcohol-dehydrogenase	gnl|CDD|176186	cd05283, CAD1, Cinnamyl alcohol dehydrogenases (CAD). Cinnamyl alcohol dehydrogenases (CAD), members of the medium chain dehydrogenase/reductase family, reduce cinnamaldehydes to cinnamyl alcohols in the last step of monolignal metabolism in plant cells walls. CAD binds 2 zinc ions and is NADPH- dependent. CAD family members are also found in non-plant species, e.g. in yeast where they have an aldehyde reductase activity. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	0
NZ_AP022590.1|WP_083092725.1|36812_37784_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	2.69337e-27
NZ_AP022590.1|WP_142275406.1|36037_36802_+|enoyl-CoA-hydratase	gnl|CDD|235632	PRK05869, PRK05869, enoyl-CoA hydratase; Validated.	6.63025e-125
NZ_AP022590.1|WP_083092724.1|39041_39722_+|DUF3298-domain-containing-protein	gnl|CDD|378702	pfam11738, DUF3298, Protein of unknown function (DUF3298). This family of bacterial protein C-terminal regions is highly conserved but the function is not known. Several members are annotated as being endo-1,4-beta-xylanase-like, but this could not be confirmed, and the structure can be defined as a heat-shock cognate 70kd protein 44kd ATPase.	1.0406e-10

Protein sequences

>NZ_AP022590.1|WP_083092734.1|29696_30794_-|iron-siderophore-ABC-transporter-substrate-binding-protein
MLFGVIRPALPAALTAAVVLACSGCESDKPAGQTPTPALITPTTQIAGAGVLGNDRRPDDSCARDAAGADAGSSKRQVHNAAGVEPDVVQVPADPQRIVVLAGDQLDTLCALGLQSRVVGAALPDGSSSQPAYLGGTVHGVPGVGTRSHPDVKAIAAAHPDLILGSQGLTPTLYPQLPAIAPTVFTAAPGAAWEDNLRAVGAATGRGAAVDTLLGGFSQRAIDIGARHDASHYQASIVQLTADTIRVYGANNFPASVLGAAGVDRPASQRFTDKPYIEIGASDADLAKNPDLSSADADVVYVSCATPAAAGRAATILDSNPWRKLSANRDNRVYVVNDEIWQTGEGLIAARGIVDDLRLVNAPIN
>NZ_AP022590.1|WP_083092735.1|28536_29577_-|NAD(P)-dependent-alcohol-dehydrogenase
MSTVSAYAATSPTAPLTKTTIERRDPGPHDVAIDIKFAGICHSDIHTAKGEWGTPNYPLVVGHEIAGVVTAVGSEVTKHKVGDHVGVGCMVNSCGQCDSCQAGLEQYCSRGTTFTYNATDRDGTTTQGGYSQAIVVDENFVLRIPDSLPLDKAAPLLCAGITLFSPLRHWKAGQDTRLAIIGLGGLGHMGVKLGAAMGAEVTVLSQSLKKMEDGLRLGAKHYYATAERETFKKLRNSFDLILNTVSANLNLNDYLSLLDVDGTLVELGIPEHPMEVGAFSLALARRSLSGSNIGGIAETQEMLDFCAEHKVTPEIELIEPDYINEAYERVLASDVRYRFVIDISKL
>NZ_AP022590.1|WP_083092738.1|27437_27698_-|hypothetical-protein
MSATGAPLIVSGILGVGEIAVGAYQHHHANKIAWKPQHSRGGLGLLAAVGATTGQLENAFPAAVLGGVAVGVNLINQTHQQRQQSA
>NZ_AP022590.1|WP_158086039.1|27250_27388_+|hypothetical-protein
MTTAEQPPPEGDEQPPQATEDEGGSDAESGERTRSPGGDAAPAGE
>NZ_AP022590.1|WP_163650788.1|26241_26784_-|hypothetical-protein
MTPENNTQCWRDLADQLTPQQVAELEEREAGYRHRATLPEDPWTSWEPRTDRAIEDALLHDGRRHAHDNLIAALMSDVPPLPDAKTFGYWETDDEHLCRFVSTPTRSVDGTKIRVLGAASQLADGSILIAQGIDVPQVRIDELSRDGYMTEVFTLSPGQARNLAAALLNTADQIDGWIAR
>NZ_AP022590.1|WP_083092742.1|25915_26245_-|hypothetical-protein
MTSPDRWRELTDAVIGHVAKPAGAVSVEEWADALTPDAFRLFYGPTRAVELGHGATMEVVTRGTQSCDGRIEDHGILVHGGSDESITATSARALAAALTEAAREIESLR
>NZ_AP022590.1|WP_083092745.1|24476_24695_-|hypothetical-protein
MTDDELPQDEAFKAERARLFAEIATLKDQRNELQRQLAECQRENSRLRAQPLAELPDSRDTADPDAEDNERE
>NZ_AP022590.1|WP_158086040.1|23764_24484_-|DUF732-domain-containing-protein
MSDDTVAGTTPGAGDAETEIVPLPTTEAPELAWSREAEETEVFSRSWGAAAERASVIVLTAAAVAALVAGAVWLGLRVYDATRPVAAPSAAAPSVVPAAALPPPIAASVPPSANPSGAPSSSSPTLDPARPRPLQYDSRGVPIIPKNPSAAELQQALVAIFDRDGIPYGSPTAASADADSVCEYLDSGHRSFADLVAWIRRARPSLMSDQVGGFAGASIGVYCPRYGYLIDSTNEGATS
>NZ_AP022590.1|WP_083093109.1|23072_23444_-|DUF4189-domain-containing-protein
MRQWCPCGGAPSLASAPAAGAAPDDDDYVSLAVSLVTGLPAGWGTAGSQDKANQIAVDQCNASTGGVCEAVAGMHNGCASVAIDPDAGRFQGGYGSDTTASNADALTELDSPSGVIAASHCSS
>NZ_AP022590.1|WP_083092749.1|22144_22882_-|hypothetical-protein
MARNHNQDDEQPLTTAAAARDETEIGAAADETELVPPIAARASELAWSDEDGAAGGDYSWGGAAERASIIVIAGAAVAVAVGLLTWLGFHLLDQPKPTVAPEATRPATIVPEALPTVTAAPPSTVTVIPPAPAPTTVTVQALPPPAPTVKPAPALPPPGGTHVFSICPDGHEGVVGGHTSCAFAANVRQVFYASGMAGSFTAFSPVTGDGYEMTCVGRYPAYFSDGSTKVSTRCYGGDNAEVVIW
>NZ_AP022590.1|WP_163650789.1|31141_32827_+|cytochrome-c-oxidase-subunit-I
MGPKGNLVYKLITTTDHKMIGIMYTVTCFAFFFIGGLMALLMRTELAAPGLQFLSNEQFNQLFTMHGTIMLLLYATPVVFGFANLVLPLQIGAPDVAFPRLNAFSYWLFLFGGLIAASGFIVPGGAADFGWTAYTPLSDAIHSPGAGGDLWITGLIVAGLGTILGAVNMITTVVCMRAPGMTMFRMPIFTWNILVTSILILIAFPILTAALFGLAADRHLGAHVYDAANGGVLLWQHLFWFFGHPEVYIIALPFFGIVTEIFPVFSRKPVFGYTTLVYATLSIAALSVAVWAHHMFATGAVLLPFFSFMTYLIAVPTGIKFFNWIGTMWKGQITFETPMLFSVGFLLTFLLGGLTGVLLASPPLDFHVTDTYFVVAHFHYVLFGTIVFATYAGIYFWFPKMTGRLLDERLGKLHFWLTFIGFHTTFLVQHWLGDLGMPRRYADYLPSDGFQPYNVVSTVGAFILGASMFPFVWNVFKSWRYGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPHMVERLRAEAHVGRAHGPSDKDVTRLDDVQVRS
>NZ_AP022590.1|WP_083092729.1|35210_36041_+|NUDIX-domain-containing-protein
MTSPDQAPLIARPAATVMLIRDDPGGIAVFLMRRHAKMEFAAGTMVFPGGGVDDRDRNADIAWAGPPPQWWAQRFGIEPDLAEALVCAAARETFEESGVLFAGPAGQAVSAPNSIVDDASVYGEARRALADGTLSFADFLRRENLELRSDLLRPWANWVTPEAERTRRYDTYFFVGALPQGQRADGDNTESDRAGWTTPEAAIDDFKAGRSFLLPPTWTQLDSLAGRTVAEVLAVERQIVPVQPNLEIQGDNWVFEFFDSDRYHQAREAGGLGWRH
>NZ_AP022590.1|WP_142275406.1|36037_36802_+|enoyl-CoA-hydratase
MSEFVSVVVSDGSQDAGLAMLLLSRPPTNAMTRQVYREVIAAAGELGRRDDAAVVILFGGHEIFSAGDDMPELRTLRSSEAESVARVRQEAIDAVAAIPKPTVAAITGYALGAGLTLALAADWRISGDNVKFGATEILAGLVPGGDAMARLTRVAGASKAKELVFSGRFVDADEALALGLIDETVAPDDVYDAAAAWARRFLDGPRHALAAAKAGINDVFGLETPERLAAERRRYVEVFSAAQGGGDLADPDGR
>NZ_AP022590.1|WP_083092725.1|36812_37784_+|class-I-SAM-dependent-methyltransferase
MTSSTDAVPTPHATAEQVEAARNDSKLAQVLYHDWEAETYDDKWSISYDQRCIDYARGRFDAIVPDEVLHELPYDRALELGCGTGFFLLNLIQSGVARRGSVTDLSPGMVKVATRNGQSLGLDIDGRVADAEGIPYEDNTFDLVVGHAVLHHIPDVELSLREVIRVLRPGGRFVFAGEPTSAGDVYARELSTLTWRIATNVTKLPGLGGWRRPQAELDESSRAAALEAIVDLHTFTPGDLERMAANAGATEVRTVSEEFTAAMFGWPVRTLEASVPPGRLGWGWAKFAFNGWKTLSWVDANVWRRVVPKGWFYNVMVTGVKPS
>NZ_AP022590.1|WP_169926937.1|37891_38971_+|class-I-SAM-dependent-methyltransferase
MGDVAVARAQFGDRAAVLVETVLLRRRALEKLGELGASDWLFTDEALQQATAAPVALHRARRLARRGVVVHDATCSIGTELAALSRCGIAAVGSDIDPVRLAMARHNVGEAAWICRADALRPVTRDAVLVVDPARRVEGRRRSRIEDYQPGLGALLDAYRGREFVVKCAPGIDFDEVRRLGFAGEIEVTSYRGSVREACLWSAGLARLGVGRRATLLDRGEQLTDTDADDCPVRPVGRWIVDPDGAVVRAGLVRHYGARHGLWQLDPDIAYLSGDRLPATDRGFEVLDQLVFDERRLRQALAALDCGSLEVLVRGVRVDPDALRKRMRLRGSRSLSVVIARIGARSASRAMAFVCRPSR
>NZ_AP022590.1|WP_083092724.1|39041_39722_+|DUF3298-domain-containing-protein
MRYAIAAALLMAAVSGAPAAAEPPSCASLGGSIEAGQMCHLQATGPNYTLNMTFPADYPDGQALTDYITQNRDGFVAVAQSSGGRDQPYQLEATTEQHGAGQPPHNTRSVVLKFFQDVGGAHPSIWYKAFNYNLGTKQPITFDNLFSPGAAPLDAIFPIVQRDLERQTPLGAAILPSTGHDPTHYQNFAITDDQLIFYFAPGEMLPAFGGPMQAQVPRNAIPPLAI
>NZ_AP022590.1|WP_083092723.1|39744_40134_-|hypothetical-protein
MPIDDPATHGVAMTKTAASPRASTADVVATSVLLVIHGGLYTASFVLLGLLVMSTDPCGSQKCGDPAWVDRAMNLGTWGGAVLLVVDIVVAVYFLVRRNRAFFVPLIGCVAQVVLVIIAAAMEIQAGPV
>NZ_AP022590.1|WP_163650933.1|40152_41247_-|PQQ-binding-like-beta-propeller-repeat-protein
MAAGPALSARGYLALNAQTSAGCSLMEWENNHNGRQRWCVRLAQGGGFAGPLLDGFDNLYVGQPGAFVSFPVTQWTRWRQPVIGMPTTPRFIAPGELLVATHLGQVLVFDSHRGQVAGSPLDLVDGVDPIDAARGLADCAPARQGCPIAAAPAVSTGNGMVVLGVWQPGAPAAGLVGLKYHPGQSPLLSREWTSDAVGAGVIASPVLSADGSTVYVNGRDQRLWALRAADAKVKWSAPLGFLAQTPPAVTPQGLIVAGGGPDTRLAAFKDAGDHADQVWRRDDVLPLSTSSLAGTGVGYTVVSGPPANGAPGMSLLIFDPGSGRTLNSYPLPAATGYPVGVSVGTDRRVVAATSDGQVYGFAPA
>NZ_AP022590.1|WP_064952277.1|41599_42337_+|acetyltransferase
MTSMWGAPVHRRWRGSNLRDPRQAKFLTLASLKWVLRNRAYTPWYLVRYWRLLKFKLANPHIITRGMVFLGKGVEIHATPELAQLEIGRWVHIGDKNTIRAHEGSLRFGDKVVLGRDNVINAYLDIELGDSVLMADWCYVCDFDHRMDNIDLPIKDQGIVKSPVRIGPDTWVGVKVSVLRGTSVGRGCVLGSHAVVRGVIPDYSIAVGAPAKVVKNRQLAWESSAAQRAELAAALADIERKKAAR
>NZ_AP022590.1|WP_083092721.1|42333_42762_-|DUF4333-domain-containing-protein
MSGLWWAGTPATAIPAGRRLLNRPSAKVGAQINCDMKVKDRPFNVNVSVTSVDGKDVKFDMVETVDKNQVASAISTQVGQQVGRRPDAVTCPDNLKGVAGATLRCQLTDGTDKYGVLVTVTDVDAGDVNFHFKVDEQPQAAG

Crispr_ID: NZ_AP022590_2

• CRISPR_ID: NZ_AP022590_2
• CRISPR_location: 187889-188000
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP022590_2

Consensus_repeat	Method
GTTGACCGATAGCGGCACTGTGACGGT	CRISPRCasFinder

spacers of NZ_AP022590_2

>2.1|187916|57|NZ_AP022590|CRISPRCasFinder
TTCTAGTGGTGGCAGCCTGACCGATGGTGGCACGGTGACGGTGTCTAGTGGTGGTTC

CRISPR arrays and Neighbor proteins around NZ_AP022590_2

CRISPR arrays

The CRISPR arrays of NZ_AP022590_2

>merge|NZ_AP022590|2|187889-188000|CRISPRCasFinder
CGTTTCGGATGGCGGGACGGTGACGGTTTCTAGTGGTGGCAGCCTGACCGATGGTGGCACGGTGACGGTGTCTAGTGGTGGTTCGTTGACCGATAGTGGGACTGTCACGGTC

>NZ_AP022590|2|2|187889-188000|CRISPRCasFinder
CGTTTCGGATGGCGGGACGGTGACGGT	TTCTAGTGGTGGCAGCCTGACCGATGGTGGCACGGTGACGGTGTCTAGTGGTGGTTC
GTTGACCGATAGTGGGACTGTCACGGTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022590.1|WP_163650794.1|190206_193968_+|S-layer-family-protein	unknown	unknown	gnl|CDD|185219
NZ_AP022590.1|WP_083098195.1|200246_200738_-|M23-family-metallopeptidase	unknown	unknown	gnl|CDD|366703
NZ_AP022590.1|WP_083097435.1|171785_172556_-|GAF-and-ANTAR-domain-containing-protein	unknown	unknown	gnl|CDD|198080
NZ_AP022590.1|WP_083098198.1|201040_201874_+|30S-ribosomal-protein-S2	unknown	unknown	gnl|CDD|235396
NZ_AP022590.1|WP_083098184.1|196366_197092_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083097442.1|175252_176764_+|YifB-family-Mg-chelatase-like-AAA-ATPase	unknown	unknown	gnl|CDD|223679
NZ_AP022590.1|WP_083097443.1|176790_177066_-|DUF4190-domain-containing-protein	unknown	unknown	gnl|CDD|379388
NZ_AP022590.1|WP_083098187.1|197259_198117_+|siderophore-interacting-protein	unknown	unknown	gnl|CDD|99790
NZ_AP022590.1|WP_083098190.1|198141_199302_+|alpha-hydroxy-acid-oxidizing-protein	unknown	unknown	gnl|CDD|239448
NZ_AP022590.1|WP_083097445.1|177176_178343_+|DNA-protecting-protein-DprA	unknown	unknown	gnl|CDD|223829
NZ_AP022590.1|WP_083098201.1|201886_202702_+|elongation-factor-Ts	unknown	unknown	gnl|CDD|236491
NZ_AP022590.1|WP_083097438.1|173938_174757_+|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	unknown	unknown	gnl|CDD|234823
NZ_AP022590.1|WP_083097433.1|170662_171382_+|ribonuclease-HII	unknown	unknown	gnl|CDD|234574
NZ_AP022590.1|WP_142275709.1|196155_196386_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083097440.1|174875_175253_+|YraN-family-protein	unknown	unknown	gnl|CDD|237119
NZ_AP022590.1|WP_083097447.1|178427_178871_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083098192.1|199334_200240_+|tyrosine-recombinase-XerC	unknown	unknown	gnl|CDD|234698
NZ_AP022590.1|WP_083097437.1|172861_173842_+|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl|CDD|187551
NZ_AP022590.1|WP_163650795.1|194021_196118_+|S-layer-family-protein	unknown	unknown	gnl|CDD|185219
NZ_AP022590.1|WP_003875077.1|171473_171779_+|DUF2469-domain-containing-protein	unknown	unknown	gnl|CDD|313765

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP022590.1|WP_163650794.1|190206_193968_+|S-layer-family-protein	gnl|CDD|185219	PRK15319, PRK15319, fibronectin-binding autotransporter adhesin ShdA.	7.29189e-07
NZ_AP022590.1|WP_083098195.1|200246_200738_-|M23-family-metallopeptidase	gnl|CDD|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	7.69005e-18
NZ_AP022590.1|WP_083097435.1|171785_172556_-|GAF-and-ANTAR-domain-containing-protein	gnl|CDD|198080	smart01012, ANTAR, ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.	7.1537e-15
NZ_AP022590.1|WP_083098198.1|201040_201874_+|30S-ribosomal-protein-S2	gnl|CDD|235396	PRK05299, rpsB, 30S ribosomal protein S2; Provisional.	4.99981e-176
NZ_AP022590.1|WP_083097442.1|175252_176764_+|YifB-family-Mg-chelatase-like-AAA-ATPase	gnl|CDD|223679	COG0606, COG0606, Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones].	0
NZ_AP022590.1|WP_083097443.1|176790_177066_-|DUF4190-domain-containing-protein	gnl|CDD|379388	pfam13828, DUF4190, Domain of unknown function (DUF4190). This integral membrane domain is functionally uncharacterized. One of the membrane helices contains two GXXG motifs that are usually associated with dimerization.	8.64056e-05
NZ_AP022590.1|WP_083098187.1|197259_198117_+|siderophore-interacting-protein	gnl|CDD|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	1.55324e-81
NZ_AP022590.1|WP_083097445.1|177176_178343_+|DNA-protecting-protein-DprA	gnl|CDD|223829	COG0758, Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion].	8.20454e-96
NZ_AP022590.1|WP_083098201.1|201886_202702_+|elongation-factor-Ts	gnl|CDD|236491	PRK09377, tsf, elongation factor Ts; Provisional.	1.33437e-128
NZ_AP022590.1|WP_083097438.1|173938_174757_+|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	gnl|CDD|234823	PRK00724, PRK00724, formate dehydrogenase accessory sulfurtransferase FdhD.	1.11192e-119
NZ_AP022590.1|WP_083097433.1|170662_171382_+|ribonuclease-HII	gnl|CDD|234574	PRK00015, rnhB, ribonuclease HII; Validated.	1.01963e-96
NZ_AP022590.1|WP_083097440.1|174875_175253_+|YraN-family-protein	gnl|CDD|237119	PRK12497, PRK12497, YraN family protein.	4.51682e-47
NZ_AP022590.1|WP_083097437.1|172861_173842_+|NAD-dependent-epimerase/dehydratase-family-protein	gnl|CDD|187551	cd05240, UDP_G4E_3_SDR_e, UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs. Members of this bacterial subgroup are identified as possible sugar epimerases, such as UDP-glucose 4 epimerase. However, while the NAD(P)-binding motif is fairly well conserved, not all members retain the canonical active site tetrad of the extended SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	5.724e-90
NZ_AP022590.1|WP_083098192.1|199334_200240_+|tyrosine-recombinase-XerC	gnl|CDD|234698	PRK00236, xerC, site-specific tyrosine recombinase XerC; Reviewed.	9.12809e-135
NZ_AP022590.1|WP_083098190.1|198141_199302_+|alpha-hydroxy-acid-oxidizing-protein	gnl|CDD|239448	cd03332, LMO_FMN, L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought to be a homooctamer with two- and four- fold axes in the center of the octamer.	0
NZ_AP022590.1|WP_163650795.1|194021_196118_+|S-layer-family-protein	gnl|CDD|185219	PRK15319, PRK15319, fibronectin-binding autotransporter adhesin ShdA.	2.72476e-09
NZ_AP022590.1|WP_003875077.1|171473_171779_+|DUF2469-domain-containing-protein	gnl|CDD|313765	pfam10611, DUF2469, Protein of unknown function (DUF2469). Member proteins often found in Actinomycetes clustered with signal peptidase and/or RNAse-HII.	5.22134e-61

Protein sequences

>NZ_AP022590.1|WP_083097447.1|178427_178871_-|hypothetical-protein
MELTAILCNHAEAQNNLLYISAGGIDQVRIPAGHSVPFTVSVGIGIIVEVPRTASDREHTVDIGLLDSDGCAVEVQKGVDGYEPFRAQFQFNIGRSSSHEADQTQSVAFAVNIPVLRLEKLGSYVFTVSVDETVQRRLPYRLVEQAA
>NZ_AP022590.1|WP_083097445.1|177176_178343_+|DNA-protecting-protein-DprA
MTPDDPAQRAWAYLSRVAEPPCAELAALVQRVGPVEAAERVRRGSVDDDLARHTEARRDIDSSAADLEMIARRGGRLITPDDDEWPLLAFAAFHGAEPRRRGGPPMVPPMVLWAQGPVRLDEAAHRAVAVVGTRASTAYGEQVAGDLAAGLAQRDVAVVSGGAYGIDGAAHRAVLDCDGITVAVLAGGLDIPYPSGHTALLHRIGQHGLLFTEYAPGIRPARYRFLTRNRLVAAVVGAAVVVEAGLRSGAASTAAWARALGRVVAAVPGPVTSSASAGCHALLRNGAELVTRADHVVELVGHIGELASDEPRPATPLDGLSDAERRVYEALPGRGGATVDEIAVASGLPPEQALGPLAMLELAGLVRRQDGCWRIVRAHGAVATAPPA
>NZ_AP022590.1|WP_083097443.1|176790_177066_-|DUF4190-domain-containing-protein
MILDLPMVYRVSERPKNPWAVAAFALSLVSWIGFPIPLISIGLACIGLREMQQRGESGRAMAQFARAFAVLVTVAIAVRGGHTDWLTMARW
>NZ_AP022590.1|WP_083097442.1|175252_176764_+|YifB-family-Mg-chelatase-like-AAA-ATPase
MALGRAFSVAVRGVDGQIVEIEADITSGLPGVHLVGLPDAALQESRDRVRAAVTNCGNAWPMARLTLALSPATLPKMGSVYDIALAAAVLSAQRKNPWDRLEKTVLLGELSLDGRVRPVRGVLPAVLAAKRDGWPAVVVPVDNLAEASLVDGIDVWGVRTLGQLQKWLGGTGALDNRIDAQPTGGEPAADLVDVVGQTQARFAVEVAAAGAHHLMLTGPPGVGKTMLAQRLPGLLPALTDAESLEVTAIHSVAGLLSGNTPLITRPPFVAPHHSSSVAALVGGGSGMARPGAVSRAHRGVLFLDECAEIRVSALEALRTPLEDGEIRLARRDGVACYPARFQLVLAANLCPCAPADPQDCICAAAAKRRYLGKLSGPLLDRVDLRVQMHQVKAGAFAGRDGESTAQVCHRVAQARAAAAQRWQPHGFHTNGEVSGTLLRRKFRPSNAAMEPLQKALDRGVLSIRGLDRTLRVAWSLADLAGRTIPGIDEVAAALSFRQPGAQR
>NZ_AP022590.1|WP_083097440.1|174875_175253_+|YraN-family-protein
MTTETTMTRIQLGAMGEALAVDHLTRVGFRILQRNWRCRYGELDIIARDDTTSTVVFVEVKTRTGDGYGGLAHAVTPRKVRRLRRLAGLWLAGQDQHSAAIRIDVIGVRIGRRRTPEITHLQGIG
>NZ_AP022590.1|WP_083097438.1|173938_174757_+|formate-dehydrogenase-accessory-sulfurtransferase-FdhD
MRHVTSRRRVTHLTAGKAITRPETLVVEEPLEIRVNGAAVTVTMRTPGADFELAQGFLLTEGVIAGRDDVLTIRYCGGAVDRENTYNVLDVTLATGVDKPTLDVTRNFYTTSSCGVCGKASLDAVRLTGRFSPGADPATVAAATLKAMPDQLRSAQKVFDSTGGLHAAALFGVDGAMLVVREDIGRHNAVDKVIGWALEHERIPPHASVLLVSGRASFELTQKAVMAGIPVLAAVSAPSSLAVSLAEESGITLVAFLREDSMNIYTRADRIT
>NZ_AP022590.1|WP_083097437.1|172861_173842_+|NAD-dependent-epimerase/dehydratase-family-protein
MGVTVAVTGPTGEIGISAVTALEREPAVDAIIGMARRPFDPSSHGWQKTTYQQGDILDREAVDALVAQADVVIHLAFIIMGSRDESARVNLEGTRNVFEATVAAERPRRLVYTSSVAAYGYHSDNPVPLTEDVPARGSAEHYYSEQKAACEELLAEITADSALEVFVLRPCVVAGPRATALADAMPWNQLPGPMRAVVKAVPILKPVVPDPGIPLQLVHHDDVAAAIALAATAPAPPGVYNIAGDGVVTVGDVARALGGRPVRVPAVAATAASAAISRVPVVPSILEWLHTARTSMVMDTTKAKTQLGWRPLHSSAETLEALASGA
>NZ_AP022590.1|WP_083097435.1|171785_172556_-|GAF-and-ANTAR-domain-containing-protein
MGDEPKAGAEAPVTGGEKADPGTVFAALAEIIYQGSDANQMYAAICIAATLVVRGCDHASLLVRDGDRYVTVGASDRLAQAIDELERRSGDGPCIDAIEEETPQIDPDLTTPSLWPKLAEVLVAETPVRGAMGFRLLVDKRKGAALNLFSDTPNIFDAESAGRAAVLAAFASVAINAVNKGEDAASLRRGLLSNREIGKAVGMLMMLHDMGEDEAFDLLRRHSQALNIKLADVAREVINQRGQLPASDDNQLPPNT
>NZ_AP022590.1|WP_003875077.1|171473_171779_+|DUF2469-domain-containing-protein
MSAEDLEKYETEMELSLYREYKDIVGQFSYVVETERRFYLANSVEMTPRNADGEVYFELRLSDAWVWDMYRPARFVKQVRVVTFKDVNIEEVEKPELRLPE
>NZ_AP022590.1|WP_083097433.1|170662_171382_+|ribonuclease-HII
MATTWPPRAVIRRSSGLRTLESALYRSGLGPVAGVDEVGRGACAGPLVVAACVLGPGRMESLAALDDSKKLTEAAREKLFPLIRRYALAYHVVFIPPAEVDRRGVHVANIEGMRRAVAGLSVRPGYVLSDGFRVPGLAVPSLPVIGGDAVAACIAAASVLAKVSRDRLMVAMEADHPGYGFALHKGYSTPAHSTALTRLGPCPEHRYSFINVRRVADGPGGRVVADCQPDPPLQHDGYR
>NZ_AP022590.1|WP_163650794.1|190206_193968_+|S-layer-family-protein
MTNMGGTIVVSTGGADSGTLMVSSGGTLTDGGTVTVSSGGVLTDSGTVTVSSGGALTDSGVVTVNSGGLLTDSGALTVNSGGTLTDSGALIIDSGVTLVDDGTLNIDSGVSLSGTIDVGSTGALDVNSGGALTVNVGGTVSDGGTVTVSSGGSLTDGGTVTVSSGGSLTDGGVLTIDSGGVLTNSGSLTVDSGVTLADNGMLNVNGGTGVAGTIDVGSTGVVNVNSGTLTIGAGGTLSDGGVVTIDSAGALTDGGTVTVNGGAVLGSAGTLADGGTLTVADGGTLSVDGGAVLGSGGLVSDSGTLTVVNGGTLSVNGGSVVGSGGTLTVGSGGVLTDEGTVTIGSGGVLGSGGGLTDGGTVTIGSTGSLVDGGTVTVTGGGVLTDGGSLTNTGGALVVSTGGVDSGTLTVSPGVTFTDSGTLTVNAGGTLTDGGTVVVSSGGSLTDGGVVTVDSGGVLTDSGVLTVNSGGTLTDGGTLSVSPGVTFTDSGSVTVSSGGSLTDGGTLSVSSGGTLTDSGTVTVASGGTLTDGGTVTVGSGGVLTDGGTVTVNVGGVLSDGGTVTVGPTGSLTDGGTVTVSSGGSLTDSGTVTVNGGSVLVPAGSLVDDGSVTVADGGVLSVDGGSVLGSGGALTDGGSLTVANGGALSVNGGSVVGSGGSLTVGSTGTLTDSGSVTVGGGGLLGSGGTLTDSGTVTVSVGGTLTDGGTVTVSSGGLLTDGGTVTVSSGGLLTDGGTVTVNAGGGLADGGTVTVGSGGVLTDSGTVTVASGGTLTDGGTVTVGSGGILTDGGTVTVNVGGVLSDSGTVTVGPTGSLTDGGTVTVSSGGSLTDGGVLTIDSGGVLTNSGSLTVDSGVTLVDGGMLNVNSGTGVAGTIDVGSTGVVNVNSGTLTIGAGGTLSDGGVVTIDSAGALTDGGTVTVNGGAVLGSAGTLADGGTLTVADGGTLSVDGGAVLGSGGLVSDSGTLTVVNGGTLSVNGGSVVGSGGTLTVGSGGVLTDEGTVTIGSGGVLGSGGGLTDGGTVTIGSTGSLVDGGTVTVTGGGVLTDSGTVTVSSGGVLTDSGTVTVSSGGVLTDSGTVTVSSGGALTDSGVVTVNSGGLLTDGGVVTVDSGGTLTDSGVLTVNSGGTLTDGGTLSVSPGVTFTDSGSVTVSSGGSLTDGGTLSVSSGGTLTDSGTVTVASGGTLTDGGTVTVGSGGVLTDSGTVTVSSGGALTDSGVVTVNSGGLLTDSGALTVNSGGTLTDSGRSSSIPVSPW
>NZ_AP022590.1|WP_163650795.1|194021_196118_+|S-layer-family-protein
MGSTGALDVNSGGALTVNVGGTVSDGGTVTVSSGGSLTDGGTVTVSSGGSLTDSGTVTVNGGSVLVPAGSLVDDGSVTVADGGVLSVDGGSVLGSGGALTDGGSLTVANGGALSVNGGSVVGSGGSLTVGSTGTLTDSGSVTVGGGGLLGSGGTLTDSGTVTVSVGGTLTDGGTVTVSSGGLLTDGGTVTVSSGGLLTDGGTVTVNAGGGLADGGTVTVGSGGVLTDSGTVTVASGGTLTDGGTVTVGSGGILTDGGTVTVNVGGVLSDSGTVTVGPTGSLTDGGTVTVSSGGSLTDGGVLTIDSGGVLTNSGSLTVDSGVTLADNGTLNINSGTGVAGTIDVGSTGVVNVDSGGTLSVGTTGTLSDGGVVSVNSGGVLTDSGTVTVNGGSVLVPAGSLVDDGSVTVADGGVLSVDGGSVLGSGGALTDGGSLTVANGGALSVNGGSVVGSGGSLTVGSTGTLTDSGSVTVGGGGLLGSGGTLTDSGTVTVSAGGILTDGGTLTINAGGTLTDSGTVTVISGGTLTDGGTFTVSVGGTLTDSGTFTVSLGGALTNGGTVTVGGTLVDSGIVTVGSGSTFTVDPGGIVPILNGGSIIVGPGEVITIGPGGSYTSTGVIGPVTIAPGTPVPPVPSHVVFGISPGGLASPGLAGLAGLSGIQPPQDNSMLAASGSDGRSCCRYIDANGGRCCWDLLASEVD
>NZ_AP022590.1|WP_142275709.1|196155_196386_-|hypothetical-protein
MEYVLTIGFPAVGRELALRLATAERGEAVWIRGAATDQLGGTDNGPRAIALPRRPEDSLDRDRGDSGVLDFVSSSR
>NZ_AP022590.1|WP_083098184.1|196366_197092_+|hypothetical-protein
MVSTYSKGLMAMLTWPGAISAATRSPDHRKSTTDNAEVRRAGTRARDDATAHDGEAGDPASAVGQAATNTTVRTADHVIVIRILQGQTVTLPFGSTIALGERTTMLVEGGSISVEGAGACVANVPVTVNDGSTVTTLGRCRATGAVIPSNTRLLAGSYGAFTLTQYRRARVEIELINGSATTGTGPHTGQVTTPALRTATATVGAEGVTITNTEGTITVTTRRYPQLGYCNGDRSPGRVRS
>NZ_AP022590.1|WP_083098187.1|197259_198117_+|siderophore-interacting-protein
MAGRPLQRFEVVGTEQLTPHMVRVVLRGKNFDAFVPSKFTDSYVKLVFVADDVDVAGLPEPLTLDSFAGLPPEKRPSVRTLTVRHVDVEARQIALDIVVHGEHGTAGQWAATARPGQPIYLMGPSGAYTPDPAADWHLLAGDESALPAIAAALEALPPSAVGKAFIEVAGQEDEIPLTGPEGVEVHWVYRGGRADLVPEDRAGDHAPLIEAVTSAPWLPGQVHVFIHGEAQAVMHNLRPYIRKERGVDAKWASSISGYWRRGRTEETFRQWKKELAQAESANSSA
>NZ_AP022590.1|WP_083098190.1|198141_199302_+|alpha-hydroxy-acid-oxidizing-protein
MAFGDYQNEIYFKGLGGVAPALPMAFAELEARAERAMSPSVWSYVTGGAGDERTQRANREAFDHWGLIPRMFVGAANRDLSVEMFGMTLPSPVFMAPIGVIGICAQDGHGDLATARAAAATGVPMMVSTLTADPMEDVAAEFGDTPGFFQLYTPKDRELAASLVRRAEAAGYKGIIVTLDTWIPGWRPRDLSTANFPQLRGLCLSNYTSDPVFRASLQRPPEVDPQGTVLQWVSTFGNPLTWDDLGWLRSLTDLPLIIKGICHPDDARRARDGGVDGIYCSTHGGRQANGGLPALACLPGVIEAADGLPVLFDSGIRSGADVVKALALGATAVGIGRPYAYGLALGGVDGIVHVLRSILAEADLIMAVDGYPTRKDLTPDTLRRVE
>NZ_AP022590.1|WP_083098192.1|199334_200240_+|tyrosine-recombinase-XerC
MPDSEPILEEFDEYLALQCGRSAHTRRAYLGDLRSLLAFIEERGAGLDALSLPLLRSWLSAAAAVGVARTTLARRTSAVKAFTAWAVRRGLMAGDPAARLQVPKAHRTLPAVLRQDQAADAMAAANSGAQQGDPLALRDRLIVEMLYATGIRVSELCGLDIDDVDTTYRLLRVLGKGNKQRSVPFGRPAGEALDAWLADGRPALANAESGPALLLGARGRRLDVRQARTVVHQTVAAVDGAPDMGPHGLRHSAATHLLEGGADLRVVQELLGHSSLATTQLYTHVAVSRLRAVHDQAHPRA
>NZ_AP022590.1|WP_083098195.1|200246_200738_-|M23-family-metallopeptidase
MRFTALLWCAGLVSTAPAVAADDRLQWPLRPPPAVTRAFDAPAPDWHPGHRGVDLAGVAGQPVYAAGAGTVVFAGLLAGRPVVSLAHPGGLHTSYEPVRATVRVGQPVTAATVIGELATGHAGCPVAACLHWGAMWGPASGAAYVDPLGLLQSTPIRLKPLNP
>NZ_AP022590.1|WP_083098198.1|201040_201874_+|30S-ribosomal-protein-S2
MAVVTMKQLLDSGTHFGHQTRRWNPKMKRFIFTDRNGIYIIDLQQTLTFIDQAYEFVKETVAHGGSVLFVGTKKQAQESVAAEATRVGMPYVNQRWLGGMLTNFQTVHKRLQRLKELEAMEQTGGFEGRTKKEILMLTREKNKLDRSLGGIRDMAKVPSAIWVVDTNKEHIAVGEARKLGIPVIAILDTNCDPDEVDYPIPGNDDAIRSAALLTKVIASAVAEGLQARSGVGRGDGKPEAEAAEPLAEWEQELLASATTTAPTDAAAGTPEPTTDPS
>NZ_AP022590.1|WP_083098201.1|201886_202702_+|elongation-factor-Ts
MANFTAADVKKLRELTGAGMLDCKNALAENDGDFDKAVEALRIKGAKDVGKRAERATAEGLVAAQGGAMIELNSETDFVAKNAEFQALADEIVAVAAQSKAADVDALKAAQAGGKTVEQAIADLSAKIGEKLELRRVAFFDGTVETYLHKRAADLPPAVGVLVEYSGSDTEAAHAVALQIAALKARFLSRDDVPEDVVASERRIAEETAKAEGKPEQALPKIVEGRLNGFFKDAVLLEQPSVSDSKKTVKALLDEAGVTVTRFVRFEVGQA

Crispr_ID: NZ_AP022590_3

• CRISPR_ID: NZ_AP022590_3
• CRISPR_location: 188225-188647
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 5 spacers

Consensus repeat of NZ_AP022590_3

Consensus_repeat	Method
GTTGACCGATAGCGGCACTGTGACGGT	CRISPRCasFinder

spacers of NZ_AP022590_3

>3.1|188252|33|NZ_AP022590|CRISPRCasFinder
CGGCGGTGGAGGGCTTTTGGGCTCGGGTGGCAC
>3.2|188312|57|NZ_AP022590|CRISPRCasFinder
TAGTGTCGGTGGCACGTTGACCGATGGCGGCACTGTGACGGTGAGCTCGGGTGGCCT
>3.3|188396|57|NZ_AP022590|CRISPRCasFinder
GAGCTCGGGTGGCCTGTTGACCGATGGTGGCACCGTGACGGTCAATGCTGGTGGCGG
>3.4|188480|57|NZ_AP022590|CRISPRCasFinder
CGGCTCGGGTGGGGTGTTGACCGATAGCGGCACGGTGACCGTCGCCAGTGGCGGCAC
>3.5|188564|57|NZ_AP022590|CRISPRCasFinder
GGGTTCGGGTGGCATCCTGACCGACGGCGGCACCGTGACTGTCAACGTCGGTGGCGT

CRISPR arrays and Neighbor proteins around NZ_AP022590_3

CRISPR arrays

The CRISPR arrays of NZ_AP022590_3

>merge|NZ_AP022590|3|188225-188647|CRISPRCasFinder
CTTGACCGATAGCGGCAGCGTCACCGTCGGCGGTGGAGGGCTTTTGGGCTCGGGTGGCACGTTGACCGATAGCGGCACTGTGACGGTTAGTGTCGGTGGCACGTTGACCGATGGCGGCACTGTGACGGTGAGCTCGGGTGGCCTGTTGACCGATGGCGGCACTGTGACGGTGAGCTCGGGTGGCCTGTTGACCGATGGTGGCACCGTGACGGTCAATGCTGGTGGCGGCCTGGCCGATGGCGGGACGGTGACGGTCGGCTCGGGTGGGGTGTTGACCGATAGCGGCACGGTGACCGTCGCCAGTGGCGGCACATTGACCGACGGCGGCACGGTGACCGTGGGTTCGGGTGGCATCCTGACCGACGGCGGCACCGTGACTGTCAACGTCGGTGGCGTTTTGTCGGATAGCGGGACCGTCACTGT

>NZ_AP022590|3|3|188225-188647|CRISPRCasFinder
CTTGACCGATAGCGGCAGCGTCACCGT	CGGCGGTGGAGGGCTTTTGGGCTCGGGTGGCAC
GTTGACCGATAGCGGCACTGTGACGGT	TAGTGTCGGTGGCACGTTGACCGATGGCGGCACTGTGACGGTGAGCTCGGGTGGCCT
GTTGACCGATGGCGGCACTGTGACGGT	GAGCTCGGGTGGCCTGTTGACCGATGGTGGCACCGTGACGGTCAATGCTGGTGGCGG
CCTGGCCGATGGCGGGACGGTGACGGT	CGGCTCGGGTGGGGTGTTGACCGATAGCGGCACGGTGACCGTCGCCAGTGGCGGCAC
ATTGACCGACGGCGGCACGGTGACCGT	GGGTTCGGGTGGCATCCTGACCGACGGCGGCACCGTGACTGTCAACGTCGGTGGCGT
TTTGTCGGATAGCGGGACCGTCACTGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022590.1|WP_163650794.1|190206_193968_+|S-layer-family-protein	unknown	unknown	gnl|CDD|185219
NZ_AP022590.1|WP_083098195.1|200246_200738_-|M23-family-metallopeptidase	unknown	unknown	gnl|CDD|366703
NZ_AP022590.1|WP_083097435.1|171785_172556_-|GAF-and-ANTAR-domain-containing-protein	unknown	unknown	gnl|CDD|198080
NZ_AP022590.1|WP_083098198.1|201040_201874_+|30S-ribosomal-protein-S2	unknown	unknown	gnl|CDD|235396
NZ_AP022590.1|WP_083098184.1|196366_197092_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083097442.1|175252_176764_+|YifB-family-Mg-chelatase-like-AAA-ATPase	unknown	unknown	gnl|CDD|223679
NZ_AP022590.1|WP_083097443.1|176790_177066_-|DUF4190-domain-containing-protein	unknown	unknown	gnl|CDD|379388
NZ_AP022590.1|WP_083098187.1|197259_198117_+|siderophore-interacting-protein	unknown	unknown	gnl|CDD|99790
NZ_AP022590.1|WP_083098190.1|198141_199302_+|alpha-hydroxy-acid-oxidizing-protein	unknown	unknown	gnl|CDD|239448
NZ_AP022590.1|WP_083097445.1|177176_178343_+|DNA-protecting-protein-DprA	unknown	unknown	gnl|CDD|223829
NZ_AP022590.1|WP_083098201.1|201886_202702_+|elongation-factor-Ts	unknown	unknown	gnl|CDD|236491
NZ_AP022590.1|WP_083097438.1|173938_174757_+|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	unknown	unknown	gnl|CDD|234823
NZ_AP022590.1|WP_083097433.1|170662_171382_+|ribonuclease-HII	unknown	unknown	gnl|CDD|234574
NZ_AP022590.1|WP_142275709.1|196155_196386_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083097440.1|174875_175253_+|YraN-family-protein	unknown	unknown	gnl|CDD|237119
NZ_AP022590.1|WP_083097447.1|178427_178871_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083098192.1|199334_200240_+|tyrosine-recombinase-XerC	unknown	unknown	gnl|CDD|234698
NZ_AP022590.1|WP_083097437.1|172861_173842_+|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl|CDD|187551
NZ_AP022590.1|WP_163650795.1|194021_196118_+|S-layer-family-protein	unknown	unknown	gnl|CDD|185219
NZ_AP022590.1|WP_003875077.1|171473_171779_+|DUF2469-domain-containing-protein	unknown	unknown	gnl|CDD|313765

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP022590.1|WP_163650794.1|190206_193968_+|S-layer-family-protein	gnl|CDD|185219	PRK15319, PRK15319, fibronectin-binding autotransporter adhesin ShdA.	7.29189e-07
NZ_AP022590.1|WP_083098195.1|200246_200738_-|M23-family-metallopeptidase	gnl|CDD|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	7.69005e-18
NZ_AP022590.1|WP_083097435.1|171785_172556_-|GAF-and-ANTAR-domain-containing-protein	gnl|CDD|198080	smart01012, ANTAR, ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.	7.1537e-15
NZ_AP022590.1|WP_083098198.1|201040_201874_+|30S-ribosomal-protein-S2	gnl|CDD|235396	PRK05299, rpsB, 30S ribosomal protein S2; Provisional.	4.99981e-176
NZ_AP022590.1|WP_083097442.1|175252_176764_+|YifB-family-Mg-chelatase-like-AAA-ATPase	gnl|CDD|223679	COG0606, COG0606, Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones].	0
NZ_AP022590.1|WP_083097443.1|176790_177066_-|DUF4190-domain-containing-protein	gnl|CDD|379388	pfam13828, DUF4190, Domain of unknown function (DUF4190). This integral membrane domain is functionally uncharacterized. One of the membrane helices contains two GXXG motifs that are usually associated with dimerization.	8.64056e-05
NZ_AP022590.1|WP_083098187.1|197259_198117_+|siderophore-interacting-protein	gnl|CDD|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	1.55324e-81
NZ_AP022590.1|WP_083097445.1|177176_178343_+|DNA-protecting-protein-DprA	gnl|CDD|223829	COG0758, Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion].	8.20454e-96
NZ_AP022590.1|WP_083098201.1|201886_202702_+|elongation-factor-Ts	gnl|CDD|236491	PRK09377, tsf, elongation factor Ts; Provisional.	1.33437e-128
NZ_AP022590.1|WP_083097438.1|173938_174757_+|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	gnl|CDD|234823	PRK00724, PRK00724, formate dehydrogenase accessory sulfurtransferase FdhD.	1.11192e-119
NZ_AP022590.1|WP_083097433.1|170662_171382_+|ribonuclease-HII	gnl|CDD|234574	PRK00015, rnhB, ribonuclease HII; Validated.	1.01963e-96
NZ_AP022590.1|WP_083097440.1|174875_175253_+|YraN-family-protein	gnl|CDD|237119	PRK12497, PRK12497, YraN family protein.	4.51682e-47
NZ_AP022590.1|WP_083097437.1|172861_173842_+|NAD-dependent-epimerase/dehydratase-family-protein	gnl|CDD|187551	cd05240, UDP_G4E_3_SDR_e, UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs. Members of this bacterial subgroup are identified as possible sugar epimerases, such as UDP-glucose 4 epimerase. However, while the NAD(P)-binding motif is fairly well conserved, not all members retain the canonical active site tetrad of the extended SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	5.724e-90
NZ_AP022590.1|WP_083098192.1|199334_200240_+|tyrosine-recombinase-XerC	gnl|CDD|234698	PRK00236, xerC, site-specific tyrosine recombinase XerC; Reviewed.	9.12809e-135
NZ_AP022590.1|WP_083098190.1|198141_199302_+|alpha-hydroxy-acid-oxidizing-protein	gnl|CDD|239448	cd03332, LMO_FMN, L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought to be a homooctamer with two- and four- fold axes in the center of the octamer.	0
NZ_AP022590.1|WP_163650795.1|194021_196118_+|S-layer-family-protein	gnl|CDD|185219	PRK15319, PRK15319, fibronectin-binding autotransporter adhesin ShdA.	2.72476e-09
NZ_AP022590.1|WP_003875077.1|171473_171779_+|DUF2469-domain-containing-protein	gnl|CDD|313765	pfam10611, DUF2469, Protein of unknown function (DUF2469). Member proteins often found in Actinomycetes clustered with signal peptidase and/or RNAse-HII.	5.22134e-61

Protein sequences

>NZ_AP022590.1|WP_083097447.1|178427_178871_-|hypothetical-protein
MELTAILCNHAEAQNNLLYISAGGIDQVRIPAGHSVPFTVSVGIGIIVEVPRTASDREHTVDIGLLDSDGCAVEVQKGVDGYEPFRAQFQFNIGRSSSHEADQTQSVAFAVNIPVLRLEKLGSYVFTVSVDETVQRRLPYRLVEQAA
>NZ_AP022590.1|WP_083097445.1|177176_178343_+|DNA-protecting-protein-DprA
MTPDDPAQRAWAYLSRVAEPPCAELAALVQRVGPVEAAERVRRGSVDDDLARHTEARRDIDSSAADLEMIARRGGRLITPDDDEWPLLAFAAFHGAEPRRRGGPPMVPPMVLWAQGPVRLDEAAHRAVAVVGTRASTAYGEQVAGDLAAGLAQRDVAVVSGGAYGIDGAAHRAVLDCDGITVAVLAGGLDIPYPSGHTALLHRIGQHGLLFTEYAPGIRPARYRFLTRNRLVAAVVGAAVVVEAGLRSGAASTAAWARALGRVVAAVPGPVTSSASAGCHALLRNGAELVTRADHVVELVGHIGELASDEPRPATPLDGLSDAERRVYEALPGRGGATVDEIAVASGLPPEQALGPLAMLELAGLVRRQDGCWRIVRAHGAVATAPPA
>NZ_AP022590.1|WP_083097443.1|176790_177066_-|DUF4190-domain-containing-protein
MILDLPMVYRVSERPKNPWAVAAFALSLVSWIGFPIPLISIGLACIGLREMQQRGESGRAMAQFARAFAVLVTVAIAVRGGHTDWLTMARW
>NZ_AP022590.1|WP_083097442.1|175252_176764_+|YifB-family-Mg-chelatase-like-AAA-ATPase
MALGRAFSVAVRGVDGQIVEIEADITSGLPGVHLVGLPDAALQESRDRVRAAVTNCGNAWPMARLTLALSPATLPKMGSVYDIALAAAVLSAQRKNPWDRLEKTVLLGELSLDGRVRPVRGVLPAVLAAKRDGWPAVVVPVDNLAEASLVDGIDVWGVRTLGQLQKWLGGTGALDNRIDAQPTGGEPAADLVDVVGQTQARFAVEVAAAGAHHLMLTGPPGVGKTMLAQRLPGLLPALTDAESLEVTAIHSVAGLLSGNTPLITRPPFVAPHHSSSVAALVGGGSGMARPGAVSRAHRGVLFLDECAEIRVSALEALRTPLEDGEIRLARRDGVACYPARFQLVLAANLCPCAPADPQDCICAAAAKRRYLGKLSGPLLDRVDLRVQMHQVKAGAFAGRDGESTAQVCHRVAQARAAAAQRWQPHGFHTNGEVSGTLLRRKFRPSNAAMEPLQKALDRGVLSIRGLDRTLRVAWSLADLAGRTIPGIDEVAAALSFRQPGAQR
>NZ_AP022590.1|WP_083097440.1|174875_175253_+|YraN-family-protein
MTTETTMTRIQLGAMGEALAVDHLTRVGFRILQRNWRCRYGELDIIARDDTTSTVVFVEVKTRTGDGYGGLAHAVTPRKVRRLRRLAGLWLAGQDQHSAAIRIDVIGVRIGRRRTPEITHLQGIG
>NZ_AP022590.1|WP_083097438.1|173938_174757_+|formate-dehydrogenase-accessory-sulfurtransferase-FdhD
MRHVTSRRRVTHLTAGKAITRPETLVVEEPLEIRVNGAAVTVTMRTPGADFELAQGFLLTEGVIAGRDDVLTIRYCGGAVDRENTYNVLDVTLATGVDKPTLDVTRNFYTTSSCGVCGKASLDAVRLTGRFSPGADPATVAAATLKAMPDQLRSAQKVFDSTGGLHAAALFGVDGAMLVVREDIGRHNAVDKVIGWALEHERIPPHASVLLVSGRASFELTQKAVMAGIPVLAAVSAPSSLAVSLAEESGITLVAFLREDSMNIYTRADRIT
>NZ_AP022590.1|WP_083097437.1|172861_173842_+|NAD-dependent-epimerase/dehydratase-family-protein
MGVTVAVTGPTGEIGISAVTALEREPAVDAIIGMARRPFDPSSHGWQKTTYQQGDILDREAVDALVAQADVVIHLAFIIMGSRDESARVNLEGTRNVFEATVAAERPRRLVYTSSVAAYGYHSDNPVPLTEDVPARGSAEHYYSEQKAACEELLAEITADSALEVFVLRPCVVAGPRATALADAMPWNQLPGPMRAVVKAVPILKPVVPDPGIPLQLVHHDDVAAAIALAATAPAPPGVYNIAGDGVVTVGDVARALGGRPVRVPAVAATAASAAISRVPVVPSILEWLHTARTSMVMDTTKAKTQLGWRPLHSSAETLEALASGA
>NZ_AP022590.1|WP_083097435.1|171785_172556_-|GAF-and-ANTAR-domain-containing-protein
MGDEPKAGAEAPVTGGEKADPGTVFAALAEIIYQGSDANQMYAAICIAATLVVRGCDHASLLVRDGDRYVTVGASDRLAQAIDELERRSGDGPCIDAIEEETPQIDPDLTTPSLWPKLAEVLVAETPVRGAMGFRLLVDKRKGAALNLFSDTPNIFDAESAGRAAVLAAFASVAINAVNKGEDAASLRRGLLSNREIGKAVGMLMMLHDMGEDEAFDLLRRHSQALNIKLADVAREVINQRGQLPASDDNQLPPNT
>NZ_AP022590.1|WP_003875077.1|171473_171779_+|DUF2469-domain-containing-protein
MSAEDLEKYETEMELSLYREYKDIVGQFSYVVETERRFYLANSVEMTPRNADGEVYFELRLSDAWVWDMYRPARFVKQVRVVTFKDVNIEEVEKPELRLPE
>NZ_AP022590.1|WP_083097433.1|170662_171382_+|ribonuclease-HII
MATTWPPRAVIRRSSGLRTLESALYRSGLGPVAGVDEVGRGACAGPLVVAACVLGPGRMESLAALDDSKKLTEAAREKLFPLIRRYALAYHVVFIPPAEVDRRGVHVANIEGMRRAVAGLSVRPGYVLSDGFRVPGLAVPSLPVIGGDAVAACIAAASVLAKVSRDRLMVAMEADHPGYGFALHKGYSTPAHSTALTRLGPCPEHRYSFINVRRVADGPGGRVVADCQPDPPLQHDGYR
>NZ_AP022590.1|WP_163650794.1|190206_193968_+|S-layer-family-protein
MTNMGGTIVVSTGGADSGTLMVSSGGTLTDGGTVTVSSGGVLTDSGTVTVSSGGALTDSGVVTVNSGGLLTDSGALTVNSGGTLTDSGALIIDSGVTLVDDGTLNIDSGVSLSGTIDVGSTGALDVNSGGALTVNVGGTVSDGGTVTVSSGGSLTDGGTVTVSSGGSLTDGGVLTIDSGGVLTNSGSLTVDSGVTLADNGMLNVNGGTGVAGTIDVGSTGVVNVNSGTLTIGAGGTLSDGGVVTIDSAGALTDGGTVTVNGGAVLGSAGTLADGGTLTVADGGTLSVDGGAVLGSGGLVSDSGTLTVVNGGTLSVNGGSVVGSGGTLTVGSGGVLTDEGTVTIGSGGVLGSGGGLTDGGTVTIGSTGSLVDGGTVTVTGGGVLTDGGSLTNTGGALVVSTGGVDSGTLTVSPGVTFTDSGTLTVNAGGTLTDGGTVVVSSGGSLTDGGVVTVDSGGVLTDSGVLTVNSGGTLTDGGTLSVSPGVTFTDSGSVTVSSGGSLTDGGTLSVSSGGTLTDSGTVTVASGGTLTDGGTVTVGSGGVLTDGGTVTVNVGGVLSDGGTVTVGPTGSLTDGGTVTVSSGGSLTDSGTVTVNGGSVLVPAGSLVDDGSVTVADGGVLSVDGGSVLGSGGALTDGGSLTVANGGALSVNGGSVVGSGGSLTVGSTGTLTDSGSVTVGGGGLLGSGGTLTDSGTVTVSVGGTLTDGGTVTVSSGGLLTDGGTVTVSSGGLLTDGGTVTVNAGGGLADGGTVTVGSGGVLTDSGTVTVASGGTLTDGGTVTVGSGGILTDGGTVTVNVGGVLSDSGTVTVGPTGSLTDGGTVTVSSGGSLTDGGVLTIDSGGVLTNSGSLTVDSGVTLVDGGMLNVNSGTGVAGTIDVGSTGVVNVNSGTLTIGAGGTLSDGGVVTIDSAGALTDGGTVTVNGGAVLGSAGTLADGGTLTVADGGTLSVDGGAVLGSGGLVSDSGTLTVVNGGTLSVNGGSVVGSGGTLTVGSGGVLTDEGTVTIGSGGVLGSGGGLTDGGTVTIGSTGSLVDGGTVTVTGGGVLTDSGTVTVSSGGVLTDSGTVTVSSGGVLTDSGTVTVSSGGALTDSGVVTVNSGGLLTDGGVVTVDSGGTLTDSGVLTVNSGGTLTDGGTLSVSPGVTFTDSGSVTVSSGGSLTDGGTLSVSSGGTLTDSGTVTVASGGTLTDGGTVTVGSGGVLTDSGTVTVSSGGALTDSGVVTVNSGGLLTDSGALTVNSGGTLTDSGRSSSIPVSPW
>NZ_AP022590.1|WP_163650795.1|194021_196118_+|S-layer-family-protein
MGSTGALDVNSGGALTVNVGGTVSDGGTVTVSSGGSLTDGGTVTVSSGGSLTDSGTVTVNGGSVLVPAGSLVDDGSVTVADGGVLSVDGGSVLGSGGALTDGGSLTVANGGALSVNGGSVVGSGGSLTVGSTGTLTDSGSVTVGGGGLLGSGGTLTDSGTVTVSVGGTLTDGGTVTVSSGGLLTDGGTVTVSSGGLLTDGGTVTVNAGGGLADGGTVTVGSGGVLTDSGTVTVASGGTLTDGGTVTVGSGGILTDGGTVTVNVGGVLSDSGTVTVGPTGSLTDGGTVTVSSGGSLTDGGVLTIDSGGVLTNSGSLTVDSGVTLADNGTLNINSGTGVAGTIDVGSTGVVNVDSGGTLSVGTTGTLSDGGVVSVNSGGVLTDSGTVTVNGGSVLVPAGSLVDDGSVTVADGGVLSVDGGSVLGSGGALTDGGSLTVANGGALSVNGGSVVGSGGSLTVGSTGTLTDSGSVTVGGGGLLGSGGTLTDSGTVTVSAGGILTDGGTLTINAGGTLTDSGTVTVISGGTLTDGGTFTVSVGGTLTDSGTFTVSLGGALTNGGTVTVGGTLVDSGIVTVGSGSTFTVDPGGIVPILNGGSIIVGPGEVITIGPGGSYTSTGVIGPVTIAPGTPVPPVPSHVVFGISPGGLASPGLAGLAGLSGIQPPQDNSMLAASGSDGRSCCRYIDANGGRCCWDLLASEVD
>NZ_AP022590.1|WP_142275709.1|196155_196386_-|hypothetical-protein
MEYVLTIGFPAVGRELALRLATAERGEAVWIRGAATDQLGGTDNGPRAIALPRRPEDSLDRDRGDSGVLDFVSSSR
>NZ_AP022590.1|WP_083098184.1|196366_197092_+|hypothetical-protein
MVSTYSKGLMAMLTWPGAISAATRSPDHRKSTTDNAEVRRAGTRARDDATAHDGEAGDPASAVGQAATNTTVRTADHVIVIRILQGQTVTLPFGSTIALGERTTMLVEGGSISVEGAGACVANVPVTVNDGSTVTTLGRCRATGAVIPSNTRLLAGSYGAFTLTQYRRARVEIELINGSATTGTGPHTGQVTTPALRTATATVGAEGVTITNTEGTITVTTRRYPQLGYCNGDRSPGRVRS
>NZ_AP022590.1|WP_083098187.1|197259_198117_+|siderophore-interacting-protein
MAGRPLQRFEVVGTEQLTPHMVRVVLRGKNFDAFVPSKFTDSYVKLVFVADDVDVAGLPEPLTLDSFAGLPPEKRPSVRTLTVRHVDVEARQIALDIVVHGEHGTAGQWAATARPGQPIYLMGPSGAYTPDPAADWHLLAGDESALPAIAAALEALPPSAVGKAFIEVAGQEDEIPLTGPEGVEVHWVYRGGRADLVPEDRAGDHAPLIEAVTSAPWLPGQVHVFIHGEAQAVMHNLRPYIRKERGVDAKWASSISGYWRRGRTEETFRQWKKELAQAESANSSA
>NZ_AP022590.1|WP_083098190.1|198141_199302_+|alpha-hydroxy-acid-oxidizing-protein
MAFGDYQNEIYFKGLGGVAPALPMAFAELEARAERAMSPSVWSYVTGGAGDERTQRANREAFDHWGLIPRMFVGAANRDLSVEMFGMTLPSPVFMAPIGVIGICAQDGHGDLATARAAAATGVPMMVSTLTADPMEDVAAEFGDTPGFFQLYTPKDRELAASLVRRAEAAGYKGIIVTLDTWIPGWRPRDLSTANFPQLRGLCLSNYTSDPVFRASLQRPPEVDPQGTVLQWVSTFGNPLTWDDLGWLRSLTDLPLIIKGICHPDDARRARDGGVDGIYCSTHGGRQANGGLPALACLPGVIEAADGLPVLFDSGIRSGADVVKALALGATAVGIGRPYAYGLALGGVDGIVHVLRSILAEADLIMAVDGYPTRKDLTPDTLRRVE
>NZ_AP022590.1|WP_083098192.1|199334_200240_+|tyrosine-recombinase-XerC
MPDSEPILEEFDEYLALQCGRSAHTRRAYLGDLRSLLAFIEERGAGLDALSLPLLRSWLSAAAAVGVARTTLARRTSAVKAFTAWAVRRGLMAGDPAARLQVPKAHRTLPAVLRQDQAADAMAAANSGAQQGDPLALRDRLIVEMLYATGIRVSELCGLDIDDVDTTYRLLRVLGKGNKQRSVPFGRPAGEALDAWLADGRPALANAESGPALLLGARGRRLDVRQARTVVHQTVAAVDGAPDMGPHGLRHSAATHLLEGGADLRVVQELLGHSSLATTQLYTHVAVSRLRAVHDQAHPRA
>NZ_AP022590.1|WP_083098195.1|200246_200738_-|M23-family-metallopeptidase
MRFTALLWCAGLVSTAPAVAADDRLQWPLRPPPAVTRAFDAPAPDWHPGHRGVDLAGVAGQPVYAAGAGTVVFAGLLAGRPVVSLAHPGGLHTSYEPVRATVRVGQPVTAATVIGELATGHAGCPVAACLHWGAMWGPASGAAYVDPLGLLQSTPIRLKPLNP
>NZ_AP022590.1|WP_083098198.1|201040_201874_+|30S-ribosomal-protein-S2
MAVVTMKQLLDSGTHFGHQTRRWNPKMKRFIFTDRNGIYIIDLQQTLTFIDQAYEFVKETVAHGGSVLFVGTKKQAQESVAAEATRVGMPYVNQRWLGGMLTNFQTVHKRLQRLKELEAMEQTGGFEGRTKKEILMLTREKNKLDRSLGGIRDMAKVPSAIWVVDTNKEHIAVGEARKLGIPVIAILDTNCDPDEVDYPIPGNDDAIRSAALLTKVIASAVAEGLQARSGVGRGDGKPEAEAAEPLAEWEQELLASATTTAPTDAAAGTPEPTTDPS
>NZ_AP022590.1|WP_083098201.1|201886_202702_+|elongation-factor-Ts
MANFTAADVKKLRELTGAGMLDCKNALAENDGDFDKAVEALRIKGAKDVGKRAERATAEGLVAAQGGAMIELNSETDFVAKNAEFQALADEIVAVAAQSKAADVDALKAAQAGGKTVEQAIADLSAKIGEKLELRRVAFFDGTVETYLHKRAADLPPAVGVLVEYSGSDTEAAHAVALQIAALKARFLSRDDVPEDVVASERRIAEETAKAEGKPEQALPKIVEGRLNGFFKDAVLLEQPSVSDSKKTVKALLDEAGVTVTRFVRFEVGQA

Crispr_ID: NZ_AP022590_4

• CRISPR_ID: NZ_AP022590_4
• CRISPR_location: 194087-194198
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP022590_4

Consensus_repeat	Method
GTTGACCGATAGCGGCACTGTGACGGT	CRISPRCasFinder

spacers of NZ_AP022590_4

>4.1|194114|57|NZ_AP022590|CRISPRCasFinder
TTCTAGTGGTGGCAGCCTGACCGATGGTGGCACGGTGACGGTGTCTAGTGGTGGTTC

CRISPR arrays and Neighbor proteins around NZ_AP022590_4

CRISPR arrays

The CRISPR arrays of NZ_AP022590_4

>merge|NZ_AP022590|4|194087-194198|CRISPRCasFinder
CGTTTCGGATGGCGGGACGGTGACGGTTTCTAGTGGTGGCAGCCTGACCGATGGTGGCACGGTGACGGTGTCTAGTGGTGGTTCGTTGACCGATAGTGGGACTGTCACGGTC

>NZ_AP022590|4|4|194087-194198|CRISPRCasFinder
CGTTTCGGATGGCGGGACGGTGACGGT	TTCTAGTGGTGGCAGCCTGACCGATGGTGGCACGGTGACGGTGTCTAGTGGTGGTTC
GTTGACCGATAGTGGGACTGTCACGGTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022590.1|WP_163650794.1|190206_193968_+|S-layer-family-protein	unknown	unknown	gnl|CDD|185219
NZ_AP022590.1|WP_083097435.1|171785_172556_-|GAF-and-ANTAR-domain-containing-protein	unknown	unknown	gnl|CDD|198080
NZ_AP022590.1|WP_083098204.1|202786_204205_+|amidase	unknown	unknown	gnl|CDD|181154
NZ_AP022590.1|WP_083098198.1|201040_201874_+|30S-ribosomal-protein-S2	unknown	unknown	gnl|CDD|235396
NZ_AP022590.1|WP_083097443.1|176790_177066_-|DUF4190-domain-containing-protein	unknown	unknown	gnl|CDD|379388
NZ_AP022590.1|WP_083097442.1|175252_176764_+|YifB-family-Mg-chelatase-like-AAA-ATPase	unknown	unknown	gnl|CDD|223679
NZ_AP022590.1|WP_083098187.1|197259_198117_+|siderophore-interacting-protein	unknown	unknown	gnl|CDD|99790
NZ_AP022590.1|WP_083098190.1|198141_199302_+|alpha-hydroxy-acid-oxidizing-protein	unknown	unknown	gnl|CDD|239448
NZ_AP022590.1|WP_083097445.1|177176_178343_+|DNA-protecting-protein-DprA	unknown	unknown	gnl|CDD|223829
NZ_AP022590.1|WP_083098192.1|199334_200240_+|tyrosine-recombinase-XerC	unknown	unknown	gnl|CDD|234698
NZ_AP022590.1|WP_083098201.1|201886_202702_+|elongation-factor-Ts	unknown	unknown	gnl|CDD|236491
NZ_AP022590.1|WP_083097438.1|173938_174757_+|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	unknown	unknown	gnl|CDD|234823
NZ_AP022590.1|WP_083098363.1|204260_204680_-|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
NZ_AP022590.1|WP_142275709.1|196155_196386_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083097440.1|174875_175253_+|YraN-family-protein	unknown	unknown	gnl|CDD|237119
NZ_AP022590.1|WP_083097447.1|178427_178871_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_163650778.1|179459_190256_+|PPE-domain-containing-protein	unknown	unknown	gnl|CDD|366325
NZ_AP022590.1|WP_083097437.1|172861_173842_+|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl|CDD|187551
NZ_AP022590.1|WP_083098184.1|196366_197092_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083098195.1|200246_200738_-|M23-family-metallopeptidase	unknown	unknown	gnl|CDD|366703

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP022590.1|WP_163650794.1|190206_193968_+|S-layer-family-protein	gnl|CDD|185219	PRK15319, PRK15319, fibronectin-binding autotransporter adhesin ShdA.	7.29189e-07
NZ_AP022590.1|WP_083097435.1|171785_172556_-|GAF-and-ANTAR-domain-containing-protein	gnl|CDD|198080	smart01012, ANTAR, ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.	7.1537e-15
NZ_AP022590.1|WP_083098204.1|202786_204205_+|amidase	gnl|CDD|181154	PRK07869, PRK07869, amidase; Provisional.	0
NZ_AP022590.1|WP_083098198.1|201040_201874_+|30S-ribosomal-protein-S2	gnl|CDD|235396	PRK05299, rpsB, 30S ribosomal protein S2; Provisional.	4.99981e-176
NZ_AP022590.1|WP_083097443.1|176790_177066_-|DUF4190-domain-containing-protein	gnl|CDD|379388	pfam13828, DUF4190, Domain of unknown function (DUF4190). This integral membrane domain is functionally uncharacterized. One of the membrane helices contains two GXXG motifs that are usually associated with dimerization.	8.64056e-05
NZ_AP022590.1|WP_083097442.1|175252_176764_+|YifB-family-Mg-chelatase-like-AAA-ATPase	gnl|CDD|223679	COG0606, COG0606, Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones].	0
NZ_AP022590.1|WP_083098187.1|197259_198117_+|siderophore-interacting-protein	gnl|CDD|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	1.55324e-81
NZ_AP022590.1|WP_083097445.1|177176_178343_+|DNA-protecting-protein-DprA	gnl|CDD|223829	COG0758, Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion].	8.20454e-96
NZ_AP022590.1|WP_083098192.1|199334_200240_+|tyrosine-recombinase-XerC	gnl|CDD|234698	PRK00236, xerC, site-specific tyrosine recombinase XerC; Reviewed.	9.12809e-135
NZ_AP022590.1|WP_083098201.1|201886_202702_+|elongation-factor-Ts	gnl|CDD|236491	PRK09377, tsf, elongation factor Ts; Provisional.	1.33437e-128
NZ_AP022590.1|WP_083097438.1|173938_174757_+|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	gnl|CDD|234823	PRK00724, PRK00724, formate dehydrogenase accessory sulfurtransferase FdhD.	1.11192e-119
NZ_AP022590.1|WP_083098363.1|204260_204680_-|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.69549e-20
NZ_AP022590.1|WP_083097440.1|174875_175253_+|YraN-family-protein	gnl|CDD|237119	PRK12497, PRK12497, YraN family protein.	4.51682e-47
NZ_AP022590.1|WP_083097437.1|172861_173842_+|NAD-dependent-epimerase/dehydratase-family-protein	gnl|CDD|187551	cd05240, UDP_G4E_3_SDR_e, UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs. Members of this bacterial subgroup are identified as possible sugar epimerases, such as UDP-glucose 4 epimerase. However, while the NAD(P)-binding motif is fairly well conserved, not all members retain the canonical active site tetrad of the extended SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	5.724e-90
NZ_AP022590.1|WP_163650778.1|179459_190256_+|PPE-domain-containing-protein	gnl|CDD|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.99117e-82
NZ_AP022590.1|WP_083098190.1|198141_199302_+|alpha-hydroxy-acid-oxidizing-protein	gnl|CDD|239448	cd03332, LMO_FMN, L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought to be a homooctamer with two- and four- fold axes in the center of the octamer.	0
NZ_AP022590.1|WP_083098195.1|200246_200738_-|M23-family-metallopeptidase	gnl|CDD|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	7.69005e-18

Protein sequences

>NZ_AP022590.1|WP_163650794.1|190206_193968_+|S-layer-family-protein
MTNMGGTIVVSTGGADSGTLMVSSGGTLTDGGTVTVSSGGVLTDSGTVTVSSGGALTDSGVVTVNSGGLLTDSGALTVNSGGTLTDSGALIIDSGVTLVDDGTLNIDSGVSLSGTIDVGSTGALDVNSGGALTVNVGGTVSDGGTVTVSSGGSLTDGGTVTVSSGGSLTDGGVLTIDSGGVLTNSGSLTVDSGVTLADNGMLNVNGGTGVAGTIDVGSTGVVNVNSGTLTIGAGGTLSDGGVVTIDSAGALTDGGTVTVNGGAVLGSAGTLADGGTLTVADGGTLSVDGGAVLGSGGLVSDSGTLTVVNGGTLSVNGGSVVGSGGTLTVGSGGVLTDEGTVTIGSGGVLGSGGGLTDGGTVTIGSTGSLVDGGTVTVTGGGVLTDGGSLTNTGGALVVSTGGVDSGTLTVSPGVTFTDSGTLTVNAGGTLTDGGTVVVSSGGSLTDGGVVTVDSGGVLTDSGVLTVNSGGTLTDGGTLSVSPGVTFTDSGSVTVSSGGSLTDGGTLSVSSGGTLTDSGTVTVASGGTLTDGGTVTVGSGGVLTDGGTVTVNVGGVLSDGGTVTVGPTGSLTDGGTVTVSSGGSLTDSGTVTVNGGSVLVPAGSLVDDGSVTVADGGVLSVDGGSVLGSGGALTDGGSLTVANGGALSVNGGSVVGSGGSLTVGSTGTLTDSGSVTVGGGGLLGSGGTLTDSGTVTVSVGGTLTDGGTVTVSSGGLLTDGGTVTVSSGGLLTDGGTVTVNAGGGLADGGTVTVGSGGVLTDSGTVTVASGGTLTDGGTVTVGSGGILTDGGTVTVNVGGVLSDSGTVTVGPTGSLTDGGTVTVSSGGSLTDGGVLTIDSGGVLTNSGSLTVDSGVTLVDGGMLNVNSGTGVAGTIDVGSTGVVNVNSGTLTIGAGGTLSDGGVVTIDSAGALTDGGTVTVNGGAVLGSAGTLADGGTLTVADGGTLSVDGGAVLGSGGLVSDSGTLTVVNGGTLSVNGGSVVGSGGTLTVGSGGVLTDEGTVTIGSGGVLGSGGGLTDGGTVTIGSTGSLVDGGTVTVTGGGVLTDSGTVTVSSGGVLTDSGTVTVSSGGVLTDSGTVTVSSGGALTDSGVVTVNSGGLLTDGGVVTVDSGGTLTDSGVLTVNSGGTLTDGGTLSVSPGVTFTDSGSVTVSSGGSLTDGGTLSVSSGGTLTDSGTVTVASGGTLTDGGTVTVGSGGVLTDSGTVTVSSGGALTDSGVVTVNSGGLLTDSGALTVNSGGTLTDSGRSSSIPVSPW
>NZ_AP022590.1|WP_163650778.1|179459_190256_+|PPE-domain-containing-protein
MDFAELPPEVNSTRMYSGPGAGPLLAAAAAWDALAAALASTASGYTSVVSELAGQVWLGPASLAMAAAAVPYAEWLATTGTQAAQTAAQAYAAAAAYEAAFIATVPPPAIAENRAELAALVATNFLGQNAPAIMATEALYMEMWAQDAAVMYGYEAASTAASALAPFGEPPRTTNPAGQGARAGAMVRAVGDSTTARIQSLTQLSSPTASQQSASTAVSQQSASTVVSQQSGSTAVSQQASSFAASQQLSASAMSQQSASNAVSSQPGATTVSQQAVSPTLSQQLGSTTVSPQSAPSSVSPQPTTTAAYQVASPATSNQPAATAVSQQSASTAVTQQSASTAVTQQVSSSAATQQLSSSAVTQQSASTAVTQQVSSSAATQQLSSSALTQQAASTTVSEGLTETHVIIDGVDPISLSGDVTGTTHLTAGNSYVILAGNTVTIDPGASLIADSGSTLTVDGTLTIDGGTLGSGGTLVDGGAITVANGGAVTVNGGALVADGGTLTVSNTLTVASGGTVTVNGGTVVGAGGGVTVSSGGVLTDSGTFTVSSGGLLGSGGTLTNSGTLTIGSGGVLADGGTVTVSSGGTLADGGSVTISSGSTLVVNSGGAVTDSGALTVSSGGTLTDGGTVTVTGGGVLTDGGTLTNTGGTVIVSTGGTDSGTLSVGSGVTFTDSGTVTIGSGGTLTDGGTVTVASGGTLTDGGTVTVASGGTLTDSGALTVNSGGVFTDSGTFTVGPGVTVVDNGTLNLNSAVSLTGSTINVGPTGALNVNSGGTLTTGLGGTLTDGGAVTVNSGGTLTDGGTVTVTGGGTLTDGGTLTNTGGTVVVSTGGTDSGTLTVGSGVTFTDSGTVTVNTGGNLTVNGALTVGPAGTLTDGGAVTVNSGGALTDGGTVTVNVGGALSDSGTVTVGPTGSLTDGGAVTVNAGGVLTDSGALSVNSGGVLTDSGTFTMDSGVTVIDNGTFNVNSGVSLTGSTINVGSTGALNVNSGGTLTVGSTGTLTDSGAVTVNAGGVLTDGGTVTVNGGAVLGSGGTLTDAGSLTVTSGGALNVNGGAVLGSGGTVTDSGSLTVANGGALSVNGGSVVGSGGTVTVGSGGTLTDGGTVTVSSGGLLGSGGTLTDGGTVTISAGGTLTDGGTVTVASGGTLTDGGTMTVASSATLTDGGTVTVSSGGTLIDSGALTVNSGGVLTDSGSFAMGSGVTVADNGTLNVNSGVTLTGSTINVGSTGALNVNSGGSLTVGSTGTLTDSGVVTVNSGGVLTDSGALTVNSDGVLTNSGSFTVGSGVTLADNGTLNINSGASVAGTINVGSASALNVNSGTLTVDATGTLSDGGVVTVSAGGVLTDGGTVTVNGGAVVGSGGILTDGGTVTVVSGGDLAVNGGAVLGSGGTASVGSGGSLSVADGGALSVNGGTVLGSGGTLTVGSGGTLTDSGTLTVGGGGVLGSGGGLTDGGTVTIGSTGSLVDGGTVTVTGGGVLTDGGSLTNTGGALVVSTGGVDSGTLTVSPGVTFTDSGTLTVNAGGTLTDGGTVVVSSGGSLTDGGVVTVDSGGVLTDSGVLTVNSGGTLTDGGTLSVSPGVTFTDSGSVTVSSGGSLTDGGTLSVGSGGVLTDSGTVTVASGGTLTDGGTVTVGSGGTVTDGGTVTVNVGGVLSDGGTVTVGPTGSLTDGGTVTVSSGGSLTDGGVLTIDSGGVLTNSGSLTVDSGVTLVDGGMLNVNSGTGVAGTIDVGSTGVVNVNSGTLTIGAGGTLSDGGVVTIDSAGALTDGGTVTVNGGAVLGSAGTLADGGTLTVADGGTLSVDGGAVLGSGGLVSDSGTLTVVNGGTLSVNGGSVVGSGGTLTVGSGGVLTDEGTVTIGSGGVLGSGGGLTDGGTVTIGSTGSLVDGGTVTVSSGGVLTDSGTVTVSSGGVLTDSGTVTVSSGGVLTDGGTVTVNVGGALSDSGTVVVSSGGTLTDSGAVTVDSGGVLTDSGVLTVNSGGTLTDGGTLSVSPGVTFTDSGSVTVSSGGSLTDGGTLSVSSGGTLTDNGTVTVASGGTLTDGGAVTVNSGGVLTDGGTVTVNGGAVLGSGGTLTDAGSLTVTDGGVLNVDAGAVLGSGGTVTDSGTLTISSGGVLADGGTVTVGSGGTLTDGGTVTVSSGATLTVDTGGALTDSGALTVSSGGTLTDGGTVTVTGGGVLTDGGAVTNMGGTIVVSTGGADSGTLMVSSGGTLTDGGTVTVSSGGVLTDSGTVTVSSGGALTDSGVVTVNSGGLLTDSGALTVNSGGTLTDSGALIIDSGVTLVDDGTLNIDSGVSLSGTIDVGSTGALDVNSGGALTVNVGGTVSDGGTVTVSSGGSLTDGGTVTVSSGGSLTDGGVLTIDSGGVLTNSGSLTVDSGVTLVDGGMLNVNSGTGVAGTIDVGSTGVVNVNSGTLTIGAGGTLSDGGVVTIDSAGALTDGGTVTVNGGAVLGSAGTLADGGTLTVADGGTLSVDGGAVLGSGGLVSDSGTLTVVNGGTLSVNGGSVVGSGGTLTVGSGGVLTDEGTVTIGSGGVLGSGGGLTDGGTVTIGSTGSLVDGGTVTVTGGGVLTDSGTVTVSSGGVLTDSGTVTVSSGGVLTDSGTVTVSSGGALTDSGVVTVNSGGLLTDSGAVTVDSGGTLTDSGVLTVNSGGTLTDGGTLSVSPGVTFTDSGSVTVSSGGSLTDGGTLSVSSGGTLTDSGTVTVASGGTLTDGGTVTVGSGGVLTDSGTVTVSSGGALTDSGVVTVNSGGLLTDSGALTVNSGGTLTDSGALIIDSGVTLVDDGTLNIDSGVSLSGTIDVGSTGALDVNSGGALTVNVGGTVSDGGTVTVSSGGSLTDGGTVTVSSGGSLTDSGTVTVNGGSVLVPAGSLVDDGSVTVADGGVLSVDGGSVLGSGGALTDGGSLTVANGGALSVNGGSVVGSGGSLTVGSTGTLTDSGSVTVGGGGLLGSGGTLTDSGTVTVSVGGTLTDGGTVTVSSGGLLTDGGTVTVSSGGLLTDGGTVTVNAGGGLADGGTVTVGSGGVLTDSGTVTVASGGTLTDGGTVTVGSGGILTDGGTVTVNVGGVLSDSGTVTVGPTGSLTDGGTVTVSSGGSLTDGGVLTIDSGGVLTNSGSLTVDSGVTLVDGGMLNVNSGTGVAGTIDVGSTGVVNVNSGTLTIGAGGTLSDGGVVTIDSAGALTDGGTVTVNGGAVLGSAGTLADGGTLTVADGGTLSVDGGAVLGSGGLVSDSGTLTVVNGGTLSVNGGSVVGSGGTLTVGSGGVLTDEGTVTIGSGGVLGSGGGLTDGGTVTIGSTGSLVDGGTVTVTGGGVLTDSGTVTVSSGGVLTDSGTVTVSSGGVLTDSGTVTVSSGGALTDSGVVTVNSGGLLTDSGAVTVNSGGTLTDSGVLTVNSGGTLTDGGTLSVSPGVTFTDSGSVTVSSGGSLTDGGTLSVSSGGTLTDNGTVTVASGGTLTDGGAVTVNSGGVLTDGGTVTVNGGAVLGSGGTLTDAGSLTVTDGGVLNVDAGAVLGSGGTVTDSGTLTISSGGVLADGGTVTVGSGGTLTDGGTVTVSSGATLTVDTGGALTDSGALTVSSGGTLTDGGTVTVTGAGAHRWGRRDQYGRDHRCQYWWRR
>NZ_AP022590.1|WP_083097447.1|178427_178871_-|hypothetical-protein
MELTAILCNHAEAQNNLLYISAGGIDQVRIPAGHSVPFTVSVGIGIIVEVPRTASDREHTVDIGLLDSDGCAVEVQKGVDGYEPFRAQFQFNIGRSSSHEADQTQSVAFAVNIPVLRLEKLGSYVFTVSVDETVQRRLPYRLVEQAA
>NZ_AP022590.1|WP_083097445.1|177176_178343_+|DNA-protecting-protein-DprA
MTPDDPAQRAWAYLSRVAEPPCAELAALVQRVGPVEAAERVRRGSVDDDLARHTEARRDIDSSAADLEMIARRGGRLITPDDDEWPLLAFAAFHGAEPRRRGGPPMVPPMVLWAQGPVRLDEAAHRAVAVVGTRASTAYGEQVAGDLAAGLAQRDVAVVSGGAYGIDGAAHRAVLDCDGITVAVLAGGLDIPYPSGHTALLHRIGQHGLLFTEYAPGIRPARYRFLTRNRLVAAVVGAAVVVEAGLRSGAASTAAWARALGRVVAAVPGPVTSSASAGCHALLRNGAELVTRADHVVELVGHIGELASDEPRPATPLDGLSDAERRVYEALPGRGGATVDEIAVASGLPPEQALGPLAMLELAGLVRRQDGCWRIVRAHGAVATAPPA
>NZ_AP022590.1|WP_083097443.1|176790_177066_-|DUF4190-domain-containing-protein
MILDLPMVYRVSERPKNPWAVAAFALSLVSWIGFPIPLISIGLACIGLREMQQRGESGRAMAQFARAFAVLVTVAIAVRGGHTDWLTMARW
>NZ_AP022590.1|WP_083097442.1|175252_176764_+|YifB-family-Mg-chelatase-like-AAA-ATPase
MALGRAFSVAVRGVDGQIVEIEADITSGLPGVHLVGLPDAALQESRDRVRAAVTNCGNAWPMARLTLALSPATLPKMGSVYDIALAAAVLSAQRKNPWDRLEKTVLLGELSLDGRVRPVRGVLPAVLAAKRDGWPAVVVPVDNLAEASLVDGIDVWGVRTLGQLQKWLGGTGALDNRIDAQPTGGEPAADLVDVVGQTQARFAVEVAAAGAHHLMLTGPPGVGKTMLAQRLPGLLPALTDAESLEVTAIHSVAGLLSGNTPLITRPPFVAPHHSSSVAALVGGGSGMARPGAVSRAHRGVLFLDECAEIRVSALEALRTPLEDGEIRLARRDGVACYPARFQLVLAANLCPCAPADPQDCICAAAAKRRYLGKLSGPLLDRVDLRVQMHQVKAGAFAGRDGESTAQVCHRVAQARAAAAQRWQPHGFHTNGEVSGTLLRRKFRPSNAAMEPLQKALDRGVLSIRGLDRTLRVAWSLADLAGRTIPGIDEVAAALSFRQPGAQR
>NZ_AP022590.1|WP_083097440.1|174875_175253_+|YraN-family-protein
MTTETTMTRIQLGAMGEALAVDHLTRVGFRILQRNWRCRYGELDIIARDDTTSTVVFVEVKTRTGDGYGGLAHAVTPRKVRRLRRLAGLWLAGQDQHSAAIRIDVIGVRIGRRRTPEITHLQGIG
>NZ_AP022590.1|WP_083097438.1|173938_174757_+|formate-dehydrogenase-accessory-sulfurtransferase-FdhD
MRHVTSRRRVTHLTAGKAITRPETLVVEEPLEIRVNGAAVTVTMRTPGADFELAQGFLLTEGVIAGRDDVLTIRYCGGAVDRENTYNVLDVTLATGVDKPTLDVTRNFYTTSSCGVCGKASLDAVRLTGRFSPGADPATVAAATLKAMPDQLRSAQKVFDSTGGLHAAALFGVDGAMLVVREDIGRHNAVDKVIGWALEHERIPPHASVLLVSGRASFELTQKAVMAGIPVLAAVSAPSSLAVSLAEESGITLVAFLREDSMNIYTRADRIT
>NZ_AP022590.1|WP_083097437.1|172861_173842_+|NAD-dependent-epimerase/dehydratase-family-protein
MGVTVAVTGPTGEIGISAVTALEREPAVDAIIGMARRPFDPSSHGWQKTTYQQGDILDREAVDALVAQADVVIHLAFIIMGSRDESARVNLEGTRNVFEATVAAERPRRLVYTSSVAAYGYHSDNPVPLTEDVPARGSAEHYYSEQKAACEELLAEITADSALEVFVLRPCVVAGPRATALADAMPWNQLPGPMRAVVKAVPILKPVVPDPGIPLQLVHHDDVAAAIALAATAPAPPGVYNIAGDGVVTVGDVARALGGRPVRVPAVAATAASAAISRVPVVPSILEWLHTARTSMVMDTTKAKTQLGWRPLHSSAETLEALASGA
>NZ_AP022590.1|WP_083097435.1|171785_172556_-|GAF-and-ANTAR-domain-containing-protein
MGDEPKAGAEAPVTGGEKADPGTVFAALAEIIYQGSDANQMYAAICIAATLVVRGCDHASLLVRDGDRYVTVGASDRLAQAIDELERRSGDGPCIDAIEEETPQIDPDLTTPSLWPKLAEVLVAETPVRGAMGFRLLVDKRKGAALNLFSDTPNIFDAESAGRAAVLAAFASVAINAVNKGEDAASLRRGLLSNREIGKAVGMLMMLHDMGEDEAFDLLRRHSQALNIKLADVAREVINQRGQLPASDDNQLPPNT
>NZ_AP022590.1|WP_142275709.1|196155_196386_-|hypothetical-protein
MEYVLTIGFPAVGRELALRLATAERGEAVWIRGAATDQLGGTDNGPRAIALPRRPEDSLDRDRGDSGVLDFVSSSR
>NZ_AP022590.1|WP_083098184.1|196366_197092_+|hypothetical-protein
MVSTYSKGLMAMLTWPGAISAATRSPDHRKSTTDNAEVRRAGTRARDDATAHDGEAGDPASAVGQAATNTTVRTADHVIVIRILQGQTVTLPFGSTIALGERTTMLVEGGSISVEGAGACVANVPVTVNDGSTVTTLGRCRATGAVIPSNTRLLAGSYGAFTLTQYRRARVEIELINGSATTGTGPHTGQVTTPALRTATATVGAEGVTITNTEGTITVTTRRYPQLGYCNGDRSPGRVRS
>NZ_AP022590.1|WP_083098187.1|197259_198117_+|siderophore-interacting-protein
MAGRPLQRFEVVGTEQLTPHMVRVVLRGKNFDAFVPSKFTDSYVKLVFVADDVDVAGLPEPLTLDSFAGLPPEKRPSVRTLTVRHVDVEARQIALDIVVHGEHGTAGQWAATARPGQPIYLMGPSGAYTPDPAADWHLLAGDESALPAIAAALEALPPSAVGKAFIEVAGQEDEIPLTGPEGVEVHWVYRGGRADLVPEDRAGDHAPLIEAVTSAPWLPGQVHVFIHGEAQAVMHNLRPYIRKERGVDAKWASSISGYWRRGRTEETFRQWKKELAQAESANSSA
>NZ_AP022590.1|WP_083098190.1|198141_199302_+|alpha-hydroxy-acid-oxidizing-protein
MAFGDYQNEIYFKGLGGVAPALPMAFAELEARAERAMSPSVWSYVTGGAGDERTQRANREAFDHWGLIPRMFVGAANRDLSVEMFGMTLPSPVFMAPIGVIGICAQDGHGDLATARAAAATGVPMMVSTLTADPMEDVAAEFGDTPGFFQLYTPKDRELAASLVRRAEAAGYKGIIVTLDTWIPGWRPRDLSTANFPQLRGLCLSNYTSDPVFRASLQRPPEVDPQGTVLQWVSTFGNPLTWDDLGWLRSLTDLPLIIKGICHPDDARRARDGGVDGIYCSTHGGRQANGGLPALACLPGVIEAADGLPVLFDSGIRSGADVVKALALGATAVGIGRPYAYGLALGGVDGIVHVLRSILAEADLIMAVDGYPTRKDLTPDTLRRVE
>NZ_AP022590.1|WP_083098192.1|199334_200240_+|tyrosine-recombinase-XerC
MPDSEPILEEFDEYLALQCGRSAHTRRAYLGDLRSLLAFIEERGAGLDALSLPLLRSWLSAAAAVGVARTTLARRTSAVKAFTAWAVRRGLMAGDPAARLQVPKAHRTLPAVLRQDQAADAMAAANSGAQQGDPLALRDRLIVEMLYATGIRVSELCGLDIDDVDTTYRLLRVLGKGNKQRSVPFGRPAGEALDAWLADGRPALANAESGPALLLGARGRRLDVRQARTVVHQTVAAVDGAPDMGPHGLRHSAATHLLEGGADLRVVQELLGHSSLATTQLYTHVAVSRLRAVHDQAHPRA
>NZ_AP022590.1|WP_083098195.1|200246_200738_-|M23-family-metallopeptidase
MRFTALLWCAGLVSTAPAVAADDRLQWPLRPPPAVTRAFDAPAPDWHPGHRGVDLAGVAGQPVYAAGAGTVVFAGLLAGRPVVSLAHPGGLHTSYEPVRATVRVGQPVTAATVIGELATGHAGCPVAACLHWGAMWGPASGAAYVDPLGLLQSTPIRLKPLNP
>NZ_AP022590.1|WP_083098198.1|201040_201874_+|30S-ribosomal-protein-S2
MAVVTMKQLLDSGTHFGHQTRRWNPKMKRFIFTDRNGIYIIDLQQTLTFIDQAYEFVKETVAHGGSVLFVGTKKQAQESVAAEATRVGMPYVNQRWLGGMLTNFQTVHKRLQRLKELEAMEQTGGFEGRTKKEILMLTREKNKLDRSLGGIRDMAKVPSAIWVVDTNKEHIAVGEARKLGIPVIAILDTNCDPDEVDYPIPGNDDAIRSAALLTKVIASAVAEGLQARSGVGRGDGKPEAEAAEPLAEWEQELLASATTTAPTDAAAGTPEPTTDPS
>NZ_AP022590.1|WP_083098201.1|201886_202702_+|elongation-factor-Ts
MANFTAADVKKLRELTGAGMLDCKNALAENDGDFDKAVEALRIKGAKDVGKRAERATAEGLVAAQGGAMIELNSETDFVAKNAEFQALADEIVAVAAQSKAADVDALKAAQAGGKTVEQAIADLSAKIGEKLELRRVAFFDGTVETYLHKRAADLPPAVGVLVEYSGSDTEAAHAVALQIAALKARFLSRDDVPEDVVASERRIAEETAKAEGKPEQALPKIVEGRLNGFFKDAVLLEQPSVSDSKKTVKALLDEAGVTVTRFVRFEVGQA
>NZ_AP022590.1|WP_083098204.1|202786_204205_+|amidase
MRHVHAFGDDALGDLDAVGLADALRSGRVGRAEVVEAAIARTEAVDPLLNGLAYAAFQQARAAAGKASEAPAAGYFGGVPTFIKDNIDVAGQPSMHGTDAWTSWDADADSVFTELFLATGLTSVGKTQLSEFGFSASAEHPRLGPVRNPWDTEYSAGASSSGSGAFVAAGVVPMAHANDGGGSIRIPAACNGLVGLKPSRGRLPLDATLRRMPVGVVVNGVVTRSVRDTAAFYREAERIWRNPKLAPVGDVSAPGRQRLRIAVLTRSVQRECSPQVRELTLKSAGLLEELGHRVEHVDEPPVAASFVEDFVMYWGFLALAQVRGGRHMFGETFDRSKLDSLTLGLLRHTSRNLHRLPTAIVRLRRARRRTARFFRTYDAVLTPTLADETPRIGFLAPTDYQQVISRLIDWVSFTPLQNVTGEPAISLPLAQSAHGMPVGMMLSADMGQEALLLELAYELEEARPWARIHGTA
>NZ_AP022590.1|WP_083098363.1|204260_204680_-|MarR-family-transcriptional-regulator
MNQADDAPLGYLLYRLGAVLRPEVSAVLSPLGLTLPEFVCLRILSMFPGMSSAELSRHTNVTPQAMNTVLRKLEEIGTVARPSSVSSGRALPANLTGQGRALLKRAEGAVRGADARILAKLTDAQQREFKRMLEKLGAD

Crispr_ID: NZ_AP022590_5

• CRISPR_ID: NZ_AP022590_5
• CRISPR_location: 194423-194845
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 5 spacers

Consensus repeat of NZ_AP022590_5

Consensus_repeat	Method
GTTGACCGATAGCGGCACTGTGACGGT	CRISPRCasFinder

spacers of NZ_AP022590_5

>5.1|194450|33|NZ_AP022590|CRISPRCasFinder
CGGCGGTGGAGGGCTTTTGGGCTCGGGTGGCAC
>5.2|194510|57|NZ_AP022590|CRISPRCasFinder
TAGTGTCGGTGGCACGTTGACCGATGGCGGCACTGTGACGGTGAGCTCGGGTGGCCT
>5.3|194594|57|NZ_AP022590|CRISPRCasFinder
GAGCTCGGGTGGCCTGTTGACCGATGGTGGCACCGTGACGGTCAATGCTGGTGGCGG
>5.4|194678|57|NZ_AP022590|CRISPRCasFinder
CGGCTCGGGTGGGGTGTTGACCGATAGCGGCACGGTGACCGTCGCCAGTGGCGGCAC
>5.5|194762|57|NZ_AP022590|CRISPRCasFinder
GGGTTCGGGTGGCATCCTGACCGACGGCGGCACCGTGACTGTCAACGTCGGTGGCGT

CRISPR arrays and Neighbor proteins around NZ_AP022590_5

CRISPR arrays

The CRISPR arrays of NZ_AP022590_5

>merge|NZ_AP022590|5|194423-194845|CRISPRCasFinder
CTTGACCGATAGCGGCAGCGTCACCGTCGGCGGTGGAGGGCTTTTGGGCTCGGGTGGCACGTTGACCGATAGCGGCACTGTGACGGTTAGTGTCGGTGGCACGTTGACCGATGGCGGCACTGTGACGGTGAGCTCGGGTGGCCTGTTGACCGATGGCGGCACTGTGACGGTGAGCTCGGGTGGCCTGTTGACCGATGGTGGCACCGTGACGGTCAATGCTGGTGGCGGCCTGGCCGATGGCGGGACGGTGACGGTCGGCTCGGGTGGGGTGTTGACCGATAGCGGCACGGTGACCGTCGCCAGTGGCGGCACATTGACCGACGGCGGCACGGTGACCGTGGGTTCGGGTGGCATCCTGACCGACGGCGGCACCGTGACTGTCAACGTCGGTGGCGTTTTGTCGGATAGCGGGACCGTCACTGT

>NZ_AP022590|5|5|194423-194845|CRISPRCasFinder
CTTGACCGATAGCGGCAGCGTCACCGT	CGGCGGTGGAGGGCTTTTGGGCTCGGGTGGCAC
GTTGACCGATAGCGGCACTGTGACGGT	TAGTGTCGGTGGCACGTTGACCGATGGCGGCACTGTGACGGTGAGCTCGGGTGGCCT
GTTGACCGATGGCGGCACTGTGACGGT	GAGCTCGGGTGGCCTGTTGACCGATGGTGGCACCGTGACGGTCAATGCTGGTGGCGG
CCTGGCCGATGGCGGGACGGTGACGGT	CGGCTCGGGTGGGGTGTTGACCGATAGCGGCACGGTGACCGTCGCCAGTGGCGGCAC
ATTGACCGACGGCGGCACGGTGACCGT	GGGTTCGGGTGGCATCCTGACCGACGGCGGCACCGTGACTGTCAACGTCGGTGGCGT
TTTGTCGGATAGCGGGACCGTCACTGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022590.1|WP_163650794.1|190206_193968_+|S-layer-family-protein	unknown	unknown	gnl|CDD|185219
NZ_AP022590.1|WP_083097435.1|171785_172556_-|GAF-and-ANTAR-domain-containing-protein	unknown	unknown	gnl|CDD|198080
NZ_AP022590.1|WP_083098204.1|202786_204205_+|amidase	unknown	unknown	gnl|CDD|181154
NZ_AP022590.1|WP_083098198.1|201040_201874_+|30S-ribosomal-protein-S2	unknown	unknown	gnl|CDD|235396
NZ_AP022590.1|WP_083097443.1|176790_177066_-|DUF4190-domain-containing-protein	unknown	unknown	gnl|CDD|379388
NZ_AP022590.1|WP_083097442.1|175252_176764_+|YifB-family-Mg-chelatase-like-AAA-ATPase	unknown	unknown	gnl|CDD|223679
NZ_AP022590.1|WP_083098187.1|197259_198117_+|siderophore-interacting-protein	unknown	unknown	gnl|CDD|99790
NZ_AP022590.1|WP_083098190.1|198141_199302_+|alpha-hydroxy-acid-oxidizing-protein	unknown	unknown	gnl|CDD|239448
NZ_AP022590.1|WP_083097445.1|177176_178343_+|DNA-protecting-protein-DprA	unknown	unknown	gnl|CDD|223829
NZ_AP022590.1|WP_083098192.1|199334_200240_+|tyrosine-recombinase-XerC	unknown	unknown	gnl|CDD|234698
NZ_AP022590.1|WP_083098201.1|201886_202702_+|elongation-factor-Ts	unknown	unknown	gnl|CDD|236491
NZ_AP022590.1|WP_083097438.1|173938_174757_+|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	unknown	unknown	gnl|CDD|234823
NZ_AP022590.1|WP_083098363.1|204260_204680_-|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
NZ_AP022590.1|WP_142275709.1|196155_196386_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083097440.1|174875_175253_+|YraN-family-protein	unknown	unknown	gnl|CDD|237119
NZ_AP022590.1|WP_083097447.1|178427_178871_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_163650778.1|179459_190256_+|PPE-domain-containing-protein	unknown	unknown	gnl|CDD|366325
NZ_AP022590.1|WP_083097437.1|172861_173842_+|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl|CDD|187551
NZ_AP022590.1|WP_083098184.1|196366_197092_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083098195.1|200246_200738_-|M23-family-metallopeptidase	unknown	unknown	gnl|CDD|366703

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP022590.1|WP_163650794.1|190206_193968_+|S-layer-family-protein	gnl|CDD|185219	PRK15319, PRK15319, fibronectin-binding autotransporter adhesin ShdA.	7.29189e-07
NZ_AP022590.1|WP_083097435.1|171785_172556_-|GAF-and-ANTAR-domain-containing-protein	gnl|CDD|198080	smart01012, ANTAR, ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.	7.1537e-15
NZ_AP022590.1|WP_083098204.1|202786_204205_+|amidase	gnl|CDD|181154	PRK07869, PRK07869, amidase; Provisional.	0
NZ_AP022590.1|WP_083098198.1|201040_201874_+|30S-ribosomal-protein-S2	gnl|CDD|235396	PRK05299, rpsB, 30S ribosomal protein S2; Provisional.	4.99981e-176
NZ_AP022590.1|WP_083097443.1|176790_177066_-|DUF4190-domain-containing-protein	gnl|CDD|379388	pfam13828, DUF4190, Domain of unknown function (DUF4190). This integral membrane domain is functionally uncharacterized. One of the membrane helices contains two GXXG motifs that are usually associated with dimerization.	8.64056e-05
NZ_AP022590.1|WP_083097442.1|175252_176764_+|YifB-family-Mg-chelatase-like-AAA-ATPase	gnl|CDD|223679	COG0606, COG0606, Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones].	0
NZ_AP022590.1|WP_083098187.1|197259_198117_+|siderophore-interacting-protein	gnl|CDD|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	1.55324e-81
NZ_AP022590.1|WP_083097445.1|177176_178343_+|DNA-protecting-protein-DprA	gnl|CDD|223829	COG0758, Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion].	8.20454e-96
NZ_AP022590.1|WP_083098192.1|199334_200240_+|tyrosine-recombinase-XerC	gnl|CDD|234698	PRK00236, xerC, site-specific tyrosine recombinase XerC; Reviewed.	9.12809e-135
NZ_AP022590.1|WP_083098201.1|201886_202702_+|elongation-factor-Ts	gnl|CDD|236491	PRK09377, tsf, elongation factor Ts; Provisional.	1.33437e-128
NZ_AP022590.1|WP_083097438.1|173938_174757_+|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	gnl|CDD|234823	PRK00724, PRK00724, formate dehydrogenase accessory sulfurtransferase FdhD.	1.11192e-119
NZ_AP022590.1|WP_083098363.1|204260_204680_-|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.69549e-20
NZ_AP022590.1|WP_083097440.1|174875_175253_+|YraN-family-protein	gnl|CDD|237119	PRK12497, PRK12497, YraN family protein.	4.51682e-47
NZ_AP022590.1|WP_083097437.1|172861_173842_+|NAD-dependent-epimerase/dehydratase-family-protein	gnl|CDD|187551	cd05240, UDP_G4E_3_SDR_e, UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs. Members of this bacterial subgroup are identified as possible sugar epimerases, such as UDP-glucose 4 epimerase. However, while the NAD(P)-binding motif is fairly well conserved, not all members retain the canonical active site tetrad of the extended SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	5.724e-90
NZ_AP022590.1|WP_163650778.1|179459_190256_+|PPE-domain-containing-protein	gnl|CDD|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.99117e-82
NZ_AP022590.1|WP_083098190.1|198141_199302_+|alpha-hydroxy-acid-oxidizing-protein	gnl|CDD|239448	cd03332, LMO_FMN, L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought to be a homooctamer with two- and four- fold axes in the center of the octamer.	0
NZ_AP022590.1|WP_083098195.1|200246_200738_-|M23-family-metallopeptidase	gnl|CDD|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	7.69005e-18

Protein sequences

>NZ_AP022590.1|WP_163650794.1|190206_193968_+|S-layer-family-protein
MTNMGGTIVVSTGGADSGTLMVSSGGTLTDGGTVTVSSGGVLTDSGTVTVSSGGALTDSGVVTVNSGGLLTDSGALTVNSGGTLTDSGALIIDSGVTLVDDGTLNIDSGVSLSGTIDVGSTGALDVNSGGALTVNVGGTVSDGGTVTVSSGGSLTDGGTVTVSSGGSLTDGGVLTIDSGGVLTNSGSLTVDSGVTLADNGMLNVNGGTGVAGTIDVGSTGVVNVNSGTLTIGAGGTLSDGGVVTIDSAGALTDGGTVTVNGGAVLGSAGTLADGGTLTVADGGTLSVDGGAVLGSGGLVSDSGTLTVVNGGTLSVNGGSVVGSGGTLTVGSGGVLTDEGTVTIGSGGVLGSGGGLTDGGTVTIGSTGSLVDGGTVTVTGGGVLTDGGSLTNTGGALVVSTGGVDSGTLTVSPGVTFTDSGTLTVNAGGTLTDGGTVVVSSGGSLTDGGVVTVDSGGVLTDSGVLTVNSGGTLTDGGTLSVSPGVTFTDSGSVTVSSGGSLTDGGTLSVSSGGTLTDSGTVTVASGGTLTDGGTVTVGSGGVLTDGGTVTVNVGGVLSDGGTVTVGPTGSLTDGGTVTVSSGGSLTDSGTVTVNGGSVLVPAGSLVDDGSVTVADGGVLSVDGGSVLGSGGALTDGGSLTVANGGALSVNGGSVVGSGGSLTVGSTGTLTDSGSVTVGGGGLLGSGGTLTDSGTVTVSVGGTLTDGGTVTVSSGGLLTDGGTVTVSSGGLLTDGGTVTVNAGGGLADGGTVTVGSGGVLTDSGTVTVASGGTLTDGGTVTVGSGGILTDGGTVTVNVGGVLSDSGTVTVGPTGSLTDGGTVTVSSGGSLTDGGVLTIDSGGVLTNSGSLTVDSGVTLVDGGMLNVNSGTGVAGTIDVGSTGVVNVNSGTLTIGAGGTLSDGGVVTIDSAGALTDGGTVTVNGGAVLGSAGTLADGGTLTVADGGTLSVDGGAVLGSGGLVSDSGTLTVVNGGTLSVNGGSVVGSGGTLTVGSGGVLTDEGTVTIGSGGVLGSGGGLTDGGTVTIGSTGSLVDGGTVTVTGGGVLTDSGTVTVSSGGVLTDSGTVTVSSGGVLTDSGTVTVSSGGALTDSGVVTVNSGGLLTDGGVVTVDSGGTLTDSGVLTVNSGGTLTDGGTLSVSPGVTFTDSGSVTVSSGGSLTDGGTLSVSSGGTLTDSGTVTVASGGTLTDGGTVTVGSGGVLTDSGTVTVSSGGALTDSGVVTVNSGGLLTDSGALTVNSGGTLTDSGRSSSIPVSPW
>NZ_AP022590.1|WP_163650778.1|179459_190256_+|PPE-domain-containing-protein
MDFAELPPEVNSTRMYSGPGAGPLLAAAAAWDALAAALASTASGYTSVVSELAGQVWLGPASLAMAAAAVPYAEWLATTGTQAAQTAAQAYAAAAAYEAAFIATVPPPAIAENRAELAALVATNFLGQNAPAIMATEALYMEMWAQDAAVMYGYEAASTAASALAPFGEPPRTTNPAGQGARAGAMVRAVGDSTTARIQSLTQLSSPTASQQSASTAVSQQSASTVVSQQSGSTAVSQQASSFAASQQLSASAMSQQSASNAVSSQPGATTVSQQAVSPTLSQQLGSTTVSPQSAPSSVSPQPTTTAAYQVASPATSNQPAATAVSQQSASTAVTQQSASTAVTQQVSSSAATQQLSSSAVTQQSASTAVTQQVSSSAATQQLSSSALTQQAASTTVSEGLTETHVIIDGVDPISLSGDVTGTTHLTAGNSYVILAGNTVTIDPGASLIADSGSTLTVDGTLTIDGGTLGSGGTLVDGGAITVANGGAVTVNGGALVADGGTLTVSNTLTVASGGTVTVNGGTVVGAGGGVTVSSGGVLTDSGTFTVSSGGLLGSGGTLTNSGTLTIGSGGVLADGGTVTVSSGGTLADGGSVTISSGSTLVVNSGGAVTDSGALTVSSGGTLTDGGTVTVTGGGVLTDGGTLTNTGGTVIVSTGGTDSGTLSVGSGVTFTDSGTVTIGSGGTLTDGGTVTVASGGTLTDGGTVTVASGGTLTDSGALTVNSGGVFTDSGTFTVGPGVTVVDNGTLNLNSAVSLTGSTINVGPTGALNVNSGGTLTTGLGGTLTDGGAVTVNSGGTLTDGGTVTVTGGGTLTDGGTLTNTGGTVVVSTGGTDSGTLTVGSGVTFTDSGTVTVNTGGNLTVNGALTVGPAGTLTDGGAVTVNSGGALTDGGTVTVNVGGALSDSGTVTVGPTGSLTDGGAVTVNAGGVLTDSGALSVNSGGVLTDSGTFTMDSGVTVIDNGTFNVNSGVSLTGSTINVGSTGALNVNSGGTLTVGSTGTLTDSGAVTVNAGGVLTDGGTVTVNGGAVLGSGGTLTDAGSLTVTSGGALNVNGGAVLGSGGTVTDSGSLTVANGGALSVNGGSVVGSGGTVTVGSGGTLTDGGTVTVSSGGLLGSGGTLTDGGTVTISAGGTLTDGGTVTVASGGTLTDGGTMTVASSATLTDGGTVTVSSGGTLIDSGALTVNSGGVLTDSGSFAMGSGVTVADNGTLNVNSGVTLTGSTINVGSTGALNVNSGGSLTVGSTGTLTDSGVVTVNSGGVLTDSGALTVNSDGVLTNSGSFTVGSGVTLADNGTLNINSGASVAGTINVGSASALNVNSGTLTVDATGTLSDGGVVTVSAGGVLTDGGTVTVNGGAVVGSGGILTDGGTVTVVSGGDLAVNGGAVLGSGGTASVGSGGSLSVADGGALSVNGGTVLGSGGTLTVGSGGTLTDSGTLTVGGGGVLGSGGGLTDGGTVTIGSTGSLVDGGTVTVTGGGVLTDGGSLTNTGGALVVSTGGVDSGTLTVSPGVTFTDSGTLTVNAGGTLTDGGTVVVSSGGSLTDGGVVTVDSGGVLTDSGVLTVNSGGTLTDGGTLSVSPGVTFTDSGSVTVSSGGSLTDGGTLSVGSGGVLTDSGTVTVASGGTLTDGGTVTVGSGGTVTDGGTVTVNVGGVLSDGGTVTVGPTGSLTDGGTVTVSSGGSLTDGGVLTIDSGGVLTNSGSLTVDSGVTLVDGGMLNVNSGTGVAGTIDVGSTGVVNVNSGTLTIGAGGTLSDGGVVTIDSAGALTDGGTVTVNGGAVLGSAGTLADGGTLTVADGGTLSVDGGAVLGSGGLVSDSGTLTVVNGGTLSVNGGSVVGSGGTLTVGSGGVLTDEGTVTIGSGGVLGSGGGLTDGGTVTIGSTGSLVDGGTVTVSSGGVLTDSGTVTVSSGGVLTDSGTVTVSSGGVLTDGGTVTVNVGGALSDSGTVVVSSGGTLTDSGAVTVDSGGVLTDSGVLTVNSGGTLTDGGTLSVSPGVTFTDSGSVTVSSGGSLTDGGTLSVSSGGTLTDNGTVTVASGGTLTDGGAVTVNSGGVLTDGGTVTVNGGAVLGSGGTLTDAGSLTVTDGGVLNVDAGAVLGSGGTVTDSGTLTISSGGVLADGGTVTVGSGGTLTDGGTVTVSSGATLTVDTGGALTDSGALTVSSGGTLTDGGTVTVTGGGVLTDGGAVTNMGGTIVVSTGGADSGTLMVSSGGTLTDGGTVTVSSGGVLTDSGTVTVSSGGALTDSGVVTVNSGGLLTDSGALTVNSGGTLTDSGALIIDSGVTLVDDGTLNIDSGVSLSGTIDVGSTGALDVNSGGALTVNVGGTVSDGGTVTVSSGGSLTDGGTVTVSSGGSLTDGGVLTIDSGGVLTNSGSLTVDSGVTLVDGGMLNVNSGTGVAGTIDVGSTGVVNVNSGTLTIGAGGTLSDGGVVTIDSAGALTDGGTVTVNGGAVLGSAGTLADGGTLTVADGGTLSVDGGAVLGSGGLVSDSGTLTVVNGGTLSVNGGSVVGSGGTLTVGSGGVLTDEGTVTIGSGGVLGSGGGLTDGGTVTIGSTGSLVDGGTVTVTGGGVLTDSGTVTVSSGGVLTDSGTVTVSSGGVLTDSGTVTVSSGGALTDSGVVTVNSGGLLTDSGAVTVDSGGTLTDSGVLTVNSGGTLTDGGTLSVSPGVTFTDSGSVTVSSGGSLTDGGTLSVSSGGTLTDSGTVTVASGGTLTDGGTVTVGSGGVLTDSGTVTVSSGGALTDSGVVTVNSGGLLTDSGALTVNSGGTLTDSGALIIDSGVTLVDDGTLNIDSGVSLSGTIDVGSTGALDVNSGGALTVNVGGTVSDGGTVTVSSGGSLTDGGTVTVSSGGSLTDSGTVTVNGGSVLVPAGSLVDDGSVTVADGGVLSVDGGSVLGSGGALTDGGSLTVANGGALSVNGGSVVGSGGSLTVGSTGTLTDSGSVTVGGGGLLGSGGTLTDSGTVTVSVGGTLTDGGTVTVSSGGLLTDGGTVTVSSGGLLTDGGTVTVNAGGGLADGGTVTVGSGGVLTDSGTVTVASGGTLTDGGTVTVGSGGILTDGGTVTVNVGGVLSDSGTVTVGPTGSLTDGGTVTVSSGGSLTDGGVLTIDSGGVLTNSGSLTVDSGVTLVDGGMLNVNSGTGVAGTIDVGSTGVVNVNSGTLTIGAGGTLSDGGVVTIDSAGALTDGGTVTVNGGAVLGSAGTLADGGTLTVADGGTLSVDGGAVLGSGGLVSDSGTLTVVNGGTLSVNGGSVVGSGGTLTVGSGGVLTDEGTVTIGSGGVLGSGGGLTDGGTVTIGSTGSLVDGGTVTVTGGGVLTDSGTVTVSSGGVLTDSGTVTVSSGGVLTDSGTVTVSSGGALTDSGVVTVNSGGLLTDSGAVTVNSGGTLTDSGVLTVNSGGTLTDGGTLSVSPGVTFTDSGSVTVSSGGSLTDGGTLSVSSGGTLTDNGTVTVASGGTLTDGGAVTVNSGGVLTDGGTVTVNGGAVLGSGGTLTDAGSLTVTDGGVLNVDAGAVLGSGGTVTDSGTLTISSGGVLADGGTVTVGSGGTLTDGGTVTVSSGATLTVDTGGALTDSGALTVSSGGTLTDGGTVTVTGAGAHRWGRRDQYGRDHRCQYWWRR
>NZ_AP022590.1|WP_083097447.1|178427_178871_-|hypothetical-protein
MELTAILCNHAEAQNNLLYISAGGIDQVRIPAGHSVPFTVSVGIGIIVEVPRTASDREHTVDIGLLDSDGCAVEVQKGVDGYEPFRAQFQFNIGRSSSHEADQTQSVAFAVNIPVLRLEKLGSYVFTVSVDETVQRRLPYRLVEQAA
>NZ_AP022590.1|WP_083097445.1|177176_178343_+|DNA-protecting-protein-DprA
MTPDDPAQRAWAYLSRVAEPPCAELAALVQRVGPVEAAERVRRGSVDDDLARHTEARRDIDSSAADLEMIARRGGRLITPDDDEWPLLAFAAFHGAEPRRRGGPPMVPPMVLWAQGPVRLDEAAHRAVAVVGTRASTAYGEQVAGDLAAGLAQRDVAVVSGGAYGIDGAAHRAVLDCDGITVAVLAGGLDIPYPSGHTALLHRIGQHGLLFTEYAPGIRPARYRFLTRNRLVAAVVGAAVVVEAGLRSGAASTAAWARALGRVVAAVPGPVTSSASAGCHALLRNGAELVTRADHVVELVGHIGELASDEPRPATPLDGLSDAERRVYEALPGRGGATVDEIAVASGLPPEQALGPLAMLELAGLVRRQDGCWRIVRAHGAVATAPPA
>NZ_AP022590.1|WP_083097443.1|176790_177066_-|DUF4190-domain-containing-protein
MILDLPMVYRVSERPKNPWAVAAFALSLVSWIGFPIPLISIGLACIGLREMQQRGESGRAMAQFARAFAVLVTVAIAVRGGHTDWLTMARW
>NZ_AP022590.1|WP_083097442.1|175252_176764_+|YifB-family-Mg-chelatase-like-AAA-ATPase
MALGRAFSVAVRGVDGQIVEIEADITSGLPGVHLVGLPDAALQESRDRVRAAVTNCGNAWPMARLTLALSPATLPKMGSVYDIALAAAVLSAQRKNPWDRLEKTVLLGELSLDGRVRPVRGVLPAVLAAKRDGWPAVVVPVDNLAEASLVDGIDVWGVRTLGQLQKWLGGTGALDNRIDAQPTGGEPAADLVDVVGQTQARFAVEVAAAGAHHLMLTGPPGVGKTMLAQRLPGLLPALTDAESLEVTAIHSVAGLLSGNTPLITRPPFVAPHHSSSVAALVGGGSGMARPGAVSRAHRGVLFLDECAEIRVSALEALRTPLEDGEIRLARRDGVACYPARFQLVLAANLCPCAPADPQDCICAAAAKRRYLGKLSGPLLDRVDLRVQMHQVKAGAFAGRDGESTAQVCHRVAQARAAAAQRWQPHGFHTNGEVSGTLLRRKFRPSNAAMEPLQKALDRGVLSIRGLDRTLRVAWSLADLAGRTIPGIDEVAAALSFRQPGAQR
>NZ_AP022590.1|WP_083097440.1|174875_175253_+|YraN-family-protein
MTTETTMTRIQLGAMGEALAVDHLTRVGFRILQRNWRCRYGELDIIARDDTTSTVVFVEVKTRTGDGYGGLAHAVTPRKVRRLRRLAGLWLAGQDQHSAAIRIDVIGVRIGRRRTPEITHLQGIG
>NZ_AP022590.1|WP_083097438.1|173938_174757_+|formate-dehydrogenase-accessory-sulfurtransferase-FdhD
MRHVTSRRRVTHLTAGKAITRPETLVVEEPLEIRVNGAAVTVTMRTPGADFELAQGFLLTEGVIAGRDDVLTIRYCGGAVDRENTYNVLDVTLATGVDKPTLDVTRNFYTTSSCGVCGKASLDAVRLTGRFSPGADPATVAAATLKAMPDQLRSAQKVFDSTGGLHAAALFGVDGAMLVVREDIGRHNAVDKVIGWALEHERIPPHASVLLVSGRASFELTQKAVMAGIPVLAAVSAPSSLAVSLAEESGITLVAFLREDSMNIYTRADRIT
>NZ_AP022590.1|WP_083097437.1|172861_173842_+|NAD-dependent-epimerase/dehydratase-family-protein
MGVTVAVTGPTGEIGISAVTALEREPAVDAIIGMARRPFDPSSHGWQKTTYQQGDILDREAVDALVAQADVVIHLAFIIMGSRDESARVNLEGTRNVFEATVAAERPRRLVYTSSVAAYGYHSDNPVPLTEDVPARGSAEHYYSEQKAACEELLAEITADSALEVFVLRPCVVAGPRATALADAMPWNQLPGPMRAVVKAVPILKPVVPDPGIPLQLVHHDDVAAAIALAATAPAPPGVYNIAGDGVVTVGDVARALGGRPVRVPAVAATAASAAISRVPVVPSILEWLHTARTSMVMDTTKAKTQLGWRPLHSSAETLEALASGA
>NZ_AP022590.1|WP_083097435.1|171785_172556_-|GAF-and-ANTAR-domain-containing-protein
MGDEPKAGAEAPVTGGEKADPGTVFAALAEIIYQGSDANQMYAAICIAATLVVRGCDHASLLVRDGDRYVTVGASDRLAQAIDELERRSGDGPCIDAIEEETPQIDPDLTTPSLWPKLAEVLVAETPVRGAMGFRLLVDKRKGAALNLFSDTPNIFDAESAGRAAVLAAFASVAINAVNKGEDAASLRRGLLSNREIGKAVGMLMMLHDMGEDEAFDLLRRHSQALNIKLADVAREVINQRGQLPASDDNQLPPNT
>NZ_AP022590.1|WP_142275709.1|196155_196386_-|hypothetical-protein
MEYVLTIGFPAVGRELALRLATAERGEAVWIRGAATDQLGGTDNGPRAIALPRRPEDSLDRDRGDSGVLDFVSSSR
>NZ_AP022590.1|WP_083098184.1|196366_197092_+|hypothetical-protein
MVSTYSKGLMAMLTWPGAISAATRSPDHRKSTTDNAEVRRAGTRARDDATAHDGEAGDPASAVGQAATNTTVRTADHVIVIRILQGQTVTLPFGSTIALGERTTMLVEGGSISVEGAGACVANVPVTVNDGSTVTTLGRCRATGAVIPSNTRLLAGSYGAFTLTQYRRARVEIELINGSATTGTGPHTGQVTTPALRTATATVGAEGVTITNTEGTITVTTRRYPQLGYCNGDRSPGRVRS
>NZ_AP022590.1|WP_083098187.1|197259_198117_+|siderophore-interacting-protein
MAGRPLQRFEVVGTEQLTPHMVRVVLRGKNFDAFVPSKFTDSYVKLVFVADDVDVAGLPEPLTLDSFAGLPPEKRPSVRTLTVRHVDVEARQIALDIVVHGEHGTAGQWAATARPGQPIYLMGPSGAYTPDPAADWHLLAGDESALPAIAAALEALPPSAVGKAFIEVAGQEDEIPLTGPEGVEVHWVYRGGRADLVPEDRAGDHAPLIEAVTSAPWLPGQVHVFIHGEAQAVMHNLRPYIRKERGVDAKWASSISGYWRRGRTEETFRQWKKELAQAESANSSA
>NZ_AP022590.1|WP_083098190.1|198141_199302_+|alpha-hydroxy-acid-oxidizing-protein
MAFGDYQNEIYFKGLGGVAPALPMAFAELEARAERAMSPSVWSYVTGGAGDERTQRANREAFDHWGLIPRMFVGAANRDLSVEMFGMTLPSPVFMAPIGVIGICAQDGHGDLATARAAAATGVPMMVSTLTADPMEDVAAEFGDTPGFFQLYTPKDRELAASLVRRAEAAGYKGIIVTLDTWIPGWRPRDLSTANFPQLRGLCLSNYTSDPVFRASLQRPPEVDPQGTVLQWVSTFGNPLTWDDLGWLRSLTDLPLIIKGICHPDDARRARDGGVDGIYCSTHGGRQANGGLPALACLPGVIEAADGLPVLFDSGIRSGADVVKALALGATAVGIGRPYAYGLALGGVDGIVHVLRSILAEADLIMAVDGYPTRKDLTPDTLRRVE
>NZ_AP022590.1|WP_083098192.1|199334_200240_+|tyrosine-recombinase-XerC
MPDSEPILEEFDEYLALQCGRSAHTRRAYLGDLRSLLAFIEERGAGLDALSLPLLRSWLSAAAAVGVARTTLARRTSAVKAFTAWAVRRGLMAGDPAARLQVPKAHRTLPAVLRQDQAADAMAAANSGAQQGDPLALRDRLIVEMLYATGIRVSELCGLDIDDVDTTYRLLRVLGKGNKQRSVPFGRPAGEALDAWLADGRPALANAESGPALLLGARGRRLDVRQARTVVHQTVAAVDGAPDMGPHGLRHSAATHLLEGGADLRVVQELLGHSSLATTQLYTHVAVSRLRAVHDQAHPRA
>NZ_AP022590.1|WP_083098195.1|200246_200738_-|M23-family-metallopeptidase
MRFTALLWCAGLVSTAPAVAADDRLQWPLRPPPAVTRAFDAPAPDWHPGHRGVDLAGVAGQPVYAAGAGTVVFAGLLAGRPVVSLAHPGGLHTSYEPVRATVRVGQPVTAATVIGELATGHAGCPVAACLHWGAMWGPASGAAYVDPLGLLQSTPIRLKPLNP
>NZ_AP022590.1|WP_083098198.1|201040_201874_+|30S-ribosomal-protein-S2
MAVVTMKQLLDSGTHFGHQTRRWNPKMKRFIFTDRNGIYIIDLQQTLTFIDQAYEFVKETVAHGGSVLFVGTKKQAQESVAAEATRVGMPYVNQRWLGGMLTNFQTVHKRLQRLKELEAMEQTGGFEGRTKKEILMLTREKNKLDRSLGGIRDMAKVPSAIWVVDTNKEHIAVGEARKLGIPVIAILDTNCDPDEVDYPIPGNDDAIRSAALLTKVIASAVAEGLQARSGVGRGDGKPEAEAAEPLAEWEQELLASATTTAPTDAAAGTPEPTTDPS
>NZ_AP022590.1|WP_083098201.1|201886_202702_+|elongation-factor-Ts
MANFTAADVKKLRELTGAGMLDCKNALAENDGDFDKAVEALRIKGAKDVGKRAERATAEGLVAAQGGAMIELNSETDFVAKNAEFQALADEIVAVAAQSKAADVDALKAAQAGGKTVEQAIADLSAKIGEKLELRRVAFFDGTVETYLHKRAADLPPAVGVLVEYSGSDTEAAHAVALQIAALKARFLSRDDVPEDVVASERRIAEETAKAEGKPEQALPKIVEGRLNGFFKDAVLLEQPSVSDSKKTVKALLDEAGVTVTRFVRFEVGQA
>NZ_AP022590.1|WP_083098204.1|202786_204205_+|amidase
MRHVHAFGDDALGDLDAVGLADALRSGRVGRAEVVEAAIARTEAVDPLLNGLAYAAFQQARAAAGKASEAPAAGYFGGVPTFIKDNIDVAGQPSMHGTDAWTSWDADADSVFTELFLATGLTSVGKTQLSEFGFSASAEHPRLGPVRNPWDTEYSAGASSSGSGAFVAAGVVPMAHANDGGGSIRIPAACNGLVGLKPSRGRLPLDATLRRMPVGVVVNGVVTRSVRDTAAFYREAERIWRNPKLAPVGDVSAPGRQRLRIAVLTRSVQRECSPQVRELTLKSAGLLEELGHRVEHVDEPPVAASFVEDFVMYWGFLALAQVRGGRHMFGETFDRSKLDSLTLGLLRHTSRNLHRLPTAIVRLRRARRRTARFFRTYDAVLTPTLADETPRIGFLAPTDYQQVISRLIDWVSFTPLQNVTGEPAISLPLAQSAHGMPVGMMLSADMGQEALLLELAYELEEARPWARIHGTA
>NZ_AP022590.1|WP_083098363.1|204260_204680_-|MarR-family-transcriptional-regulator
MNQADDAPLGYLLYRLGAVLRPEVSAVLSPLGLTLPEFVCLRILSMFPGMSSAELSRHTNVTPQAMNTVLRKLEEIGTVARPSSVSSGRALPANLTGQGRALLKRAEGAVRGADARILAKLTDAQQREFKRMLEKLGAD

Crispr_ID: NZ_AP022590_6

• CRISPR_ID: NZ_AP022590_6
• CRISPR_location: 1477438-1477543
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP022590_6

Consensus_repeat	Method
CCGTCAATACGTCACTGTGACAAAT	CRISPRCasFinder

spacers of NZ_AP022590_6

>6.1|1477463|56|NZ_AP022590|CRISPRCasFinder
AGCCATGCCCCGGGCAGGCGCCCCCGGGCACCCCATCCCCGCCTCCCCGTCCATCG

CRISPR arrays and Neighbor proteins around NZ_AP022590_6

CRISPR arrays

The CRISPR arrays of NZ_AP022590_6

>merge|NZ_AP022590|6|1477438-1477543|CRISPRCasFinder
CCGTCAATACGTCACTGTGACAAATAGCCATGCCCCGGGCAGGCGCCCCCGGGCACCCCATCCCCGCCTCCCCGTCCATCGCCGCCAATACGTCACTGTGACAAAT

>NZ_AP022590|6|6|1477438-1477543|CRISPRCasFinder
CCGTCAATACGTCACTGTGACAAAT	AGCCATGCCCCGGGCAGGCGCCCCCGGGCACCCCATCCCCGCCTCCCCGTCCATCG
CCGCCAATACGTCACTGTGACAAAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022590.1|WP_083092418.1|1476231_1476480_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083092436.1|1467177_1470540_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|227250
NZ_AP022590.1|WP_083092397.1|1487221_1488004_-|glucose-1-dehydrogenase	unknown	unknown	gnl|CDD|187600
NZ_AP022590.1|WP_163650819.1|1474709_1474853_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_169926933.1|1477815_1478046_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083092422.1|1475228_1475837_+|hypothetical-protein	unknown	unknown	gnl|CDD|377971
NZ_AP022590.1|WP_083092407.1|1481024_1481696_+|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl|CDD|215151
NZ_AP022590.1|WP_083092424.1|1474122_1474578_-|MPT63-family-protein	unknown	unknown	gnl|CDD|370335
NZ_AP022590.1|WP_083092412.1|1479204_1480212_-|GTP-binding-protein	unknown	unknown	gnl|CDD|223597
NZ_AP022590.1|WP_083092410.1|1480353_1480983_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NZ_AP022590.1|WP_083092403.1|1482904_1483513_+|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|188483
NZ_AP022590.1|WP_083092399.1|1484239_1487140_+|MMPL-family-transporter	unknown	unknown	gnl|CDD|225272
NZ_AP022590.1|WP_083092415.1|1477586_1477829_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083092430.1|1472973_1473231_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083092405.1|1481769_1482696_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|369561
NZ_AP022590.1|WP_083092401.1|1483826_1484243_+|hypothetical-protein	unknown	unknown	gnl|CDD|283157
NZ_AP022590.1|WP_083092438.1|1466790_1467111_+|hypothetical-protein	unknown	unknown	gnl|CDD|188093
NZ_AP022590.1|WP_142275395.1|1473218_1473554_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083092434.1|1470532_1471255_-|DUF4194-domain-containing-protein	unknown	unknown	gnl|CDD|372745
NZ_AP022590.1|WP_083092432.1|1471251_1472754_-|DUF3375-domain-containing-protein	unknown	unknown	gnl|CDD|371764

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP022590.1|WP_083092436.1|1467177_1470540_-|AAA-family-ATPase	gnl|CDD|227250	COG4913, COG4913, Uncharacterized protein conserved in bacteria [Function unknown].	6.73167e-102
NZ_AP022590.1|WP_083092412.1|1479204_1480212_-|GTP-binding-protein	gnl|CDD|223597	COG0523, COG0523, Putative GTPases (G3E family) [General function prediction only].	7.86996e-51
NZ_AP022590.1|WP_083092397.1|1487221_1488004_-|glucose-1-dehydrogenase	gnl|CDD|187600	cd05341, 3beta-17beta-HSD_like_SDR_c, 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs. This subgroup includes members identified as 3beta17beta hydroxysteroid dehydrogenase, 20beta hydroxysteroid dehydrogenase, and R-alcohol dehydrogenase. These proteins exhibit the canonical active site tetrad and glycine rich NAD(P)-binding motif of the classical SDRs. 17beta-dehydrogenases are a group of isozymes that catalyze activation and inactivation of estrogen and androgens, and include members of the SDR family. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	1.01283e-125
NZ_AP022590.1|WP_083092422.1|1475228_1475837_+|hypothetical-protein	gnl|CDD|377971	pfam08310, LGFP, LGFP repeat. This 54 amino acid repeat is found in many hypothetical proteins. Several hypothetical proteins from C.glutamicum and C.efficiens along with PS1 protein contain this repeat region. The N-terminus region of PS1 contains an esterase domain which transfers corynomycolic acid. The C-terminus region consists of 4 tandem LGFP repeats. It is hypothesized that the PS1 proteins in Corynebacterium, when associated with the cell wall, may be anchored via the LGFP tandem repeats that may be important for maintaining cell wall integrity [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16]. Deletion of Corynebacterium glutamicum csp1 protein results in a 10-fold increase in the cell volume of the organism and infers the corresponding proteins involvement in the cell shape formation. The secondary structure of each repeat is predicted to comprise two beta-strands and one alpha-helix [Adindla et al. 2004].	0.00615208
NZ_AP022590.1|WP_083092403.1|1482904_1483513_+|TetR-family-transcriptional-regulator	gnl|CDD|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	4.91498e-15
NZ_AP022590.1|WP_083092424.1|1474122_1474578_-|MPT63-family-protein	gnl|CDD|370335	pfam09167, DUF1942, Domain of unknown function (DUF1942). Members of this family of bacterial proteins assume a beta-sandwich structure consisting of two antiparallel beta-sheets similar to an immunoglobulin-like fold, with an additional small, antiparallel beta-sheet. The longer-stranded beta-sheet is made up of four antiparallel beta-strands. The shorter-stranded beta-sheet consists of five beta-strands, four of these beta-strands form an antiparallel beta-sheet. The exact function of this family of proteins is unknown, though a putative role includes involvement in host-bacterial interactions involved in endocytosis or phagocytosis, possibly during bacterial internalisation.	4.90771e-40
NZ_AP022590.1|WP_083092407.1|1481024_1481696_+|enoyl-CoA-hydratase/isomerase-family-protein	gnl|CDD|215151	PLN02267, PLN02267, enoyl-CoA hydratase/isomerase family protein.	2.08113e-42
NZ_AP022590.1|WP_083092410.1|1480353_1480983_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.01089e-06
NZ_AP022590.1|WP_083092401.1|1483826_1484243_+|hypothetical-protein	gnl|CDD|283157	pfam05423, Mycobact_memb, Mycobacterium membrane protein. This family contains several membrane proteins from Mycobacterium species.	6.45116e-59
NZ_AP022590.1|WP_083092399.1|1484239_1487140_+|MMPL-family-transporter	gnl|CDD|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	0
NZ_AP022590.1|WP_083092405.1|1481769_1482696_+|alpha/beta-hydrolase	gnl|CDD|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	7.35572e-71
NZ_AP022590.1|WP_083092438.1|1466790_1467111_+|hypothetical-protein	gnl|CDD|188093	TIGR00864, PCC, polycystin cation channel protein. The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.	0.00337361
NZ_AP022590.1|WP_083092434.1|1470532_1471255_-|DUF4194-domain-containing-protein	gnl|CDD|372745	pfam13835, DUF4194, Domain of unknown function (DUF4194).	6.64544e-35
NZ_AP022590.1|WP_083092432.1|1471251_1472754_-|DUF3375-domain-containing-protein	gnl|CDD|371764	pfam11855, DUF3375, Protein of unknown function (DUF3375). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 479 to 499 amino acids in length.	1.10035e-95

Protein sequences

>NZ_AP022590.1|WP_083092418.1|1476231_1476480_+|hypothetical-protein
MTTAIAEHQPAQGEGASHARDDVTLAVARLNAIAWRGDTVLAELKPRWRPTEEDIVRASITVIFVALVAVIGIAAGAILTMG
>NZ_AP022590.1|WP_083092422.1|1475228_1475837_+|hypothetical-protein
MRTIAYRHAAGVGMAAVALITVSCSSGKSVDASAPPQAKVSATSTSQAPAQPSEVKIIGERDVEVTLTGPIAAKYSSATQDQRQALGKPLTGDRNAGTRESGVVFQQFQGGAITARNGEAGTPAYIILGKIREAWNVPRSPDGVPAVSGTNGSAGPLGLPISDQNAVGDLLVSNFEHGSIGYNPKTGQVEVTVNGKAVPPGL
>NZ_AP022590.1|WP_163650819.1|1474709_1474853_-|hypothetical-protein
MKSIMGWAGVFYDIASVSGTTRYAGVEHQAFPVNQANTNGEFALTSS
>NZ_AP022590.1|WP_083092424.1|1474122_1474578_-|MPT63-family-protein
MAFSHIASKTMAATAVFAAAGLLAPAPAFADPQVLQFGQMAEISSNGGTIDYTVSNLQPSGHNDGVWYSDVTAKGVSGNATPNIADFNARAANSSTFAVMKGNQTDGLPEGPLPLGNPVTGRIYFDVRNGTNPDSVVYRDAGGADKVVWKG
>NZ_AP022590.1|WP_142275395.1|1473218_1473554_-|hypothetical-protein
MGTTSQIATSAPSVATSVSPTGQPVGTAVMKVSGGSSPVTIRYRINGGPEQTESNVPLPWEKQYPVYNEVESQVAADGGDTPLTCTIIMDGDKVVSLKSEPRPTCNFAYWG
>NZ_AP022590.1|WP_083092430.1|1472973_1473231_+|hypothetical-protein
MTALLVGKALLLAFLVVAGGVLIVTYVRRRRAGVQPWKNLYAAPYLDIYGGGLPPIPPPPLTAYEWSADGDPPTQGPDGVGGQPQ
>NZ_AP022590.1|WP_083092432.1|1471251_1472754_-|DUF3375-domain-containing-protein
MTERDGGRVLDDDTTLSPADLLELNRGLQGSPTIRLLATLNLNLYATLMERRLSGGVVPETDLVVRLERDLAALDQAGEQSGLALIKSWASQGWLHRVADQRSGVERNLCYLTQEARRALDFLRGMRRQDTIATGGSINGIASRLKQVALRVGNNPDRIRANIEAEIAALQTELDALAQSDSSGDHTQDVDLTDAYDEAHAIALQMERLITDIGQYGTMIERATAALDDPIDSNVEYRDRQRRMYADYEAAWDSQGRDSHRAFLRMINDPDQRAEFEADVAAVADALPALDPALRKVMAGFFELVGHQIDEVERIQQRCAQRVKRFTAFGTLEQSRGVARQLNEAIGAARNLLKASLTDSRLDIELPLARHAFSSVGALSFRIGDLSNPKPAQAAEGEVDLTSFAALTTQVDAPAMSEMINTAIRSGATLSLPDAVAMLDSAYLGHVIVLWSWALKQPESAQVSESVTVRFQSLDGRDREMEVPHLMFTEPVSTLLGATA
>NZ_AP022590.1|WP_083092434.1|1470532_1471255_-|DUF4194-domain-containing-protein
MTVEEATREPTDYSGFSALPHVDQTARAPHQRRPRFDGDVSELPDRACWALQQLLTRRYISAEADRDVYTWVLEYRAQLSVRLSELDLLLRIVEGADVAFVEQARYESARGVKLLRREPLGTYDSILALHLAQMMRASGDQAVVISRDEMHGLFSGVLNDVDRDAVTFTARIDGAIARLASLEILRKTRDDEDSYTVSPVINAVMTASVISELQRQFEILLGGGVPDEQGHDDEEEREDD
>NZ_AP022590.1|WP_083092436.1|1467177_1470540_-|AAA-family-ATPase
MTEQFHLSRLQVINWGVFDGYHSIPFSEGGALIAGASGSGKSSLLDAISLGFLPFNRRNFNASGDNTAAGSSAGRRTVDKYVRGAWGQRSEAGASKVMYLRGDGTAWSAIAVTYTSNSGRTVTGLVLKWLTGESRSDSSSRFVLADGDRDIENVCNRWAAGRFDAAVFKDDWRFSTKVESQYLAQLYATIGIRASDAAQQLLGKAKSLKSVGGLEQFVREFMLDEPASLTRLPEALKQIDPLVDARELLAVAQRKRKILGDIEKIQQRYASESSDLGIIDLVDQPMVRAYTDHLRLAQCPAQIESLDATIDQLGNEYEDVTRQLNLAKAEGDSLNTQISGSSTSLGPLQSQVAGAEAHAEQVSRRRTAYESMLNTHGLDIPDSADEFWNLREELSTRATELLAKLDRGREASTDAEYAQKVARIARDDAAKELKRVERVGSALPEFALTMREHICAAVGIDPGELPYIAELMDLRPEQSRWRVAVEKVLRGVGLRLLVPDTHYAAVLRFVNETNMGGRLQLHHVRARFVGADVTEADPNTLAGKLFVVDPTHDCAAEAADVIAAAGDHICVDTPDVFSRFRRAVTDTGLYKESERLAIKDDRRPLKQADYIYQGDVAAKIDALTVDLANAEEAFRRARAVADDIAAERQQWRDRAAAFKAICDQFEQWTHVDTDTADGHADRLREQFELLLADNPDIEALTARAEECWEQIQALMTRRGAIQTRRDDLDGRRTRLLELLERLAPAFVSEPLTDLLNRYAADVPVSLDMLNPEPHRDAVFTAIRREREQLRESRRRSYDELARILNTFDTAFPDAIPNDSDVFDERVHDYVALCRHIDERELPEAYERMLRLVTEQAPDAILTLHRVAEQEARRISEQIERVNTGLGAVEFNRGTRLTLRATSRSLTAVAELTEIVRSISRRIAEVGLGDKQAILDQYADILRLRNRLASTAPEDKAWTRDALDVRNRFTFDCAEWDVSSDDLIRTHSNSGDNSGGEQEKLMAFCLAGALSFNLANPESADNKPVFAQLMLDEAFSKSDPQFAQQALQAFRKFGFQLVIVATVQNATTIQPYIDSVVMVSKREATGRNARPVATVTTKTITDFTALRHELRTSAALVPAGV
>NZ_AP022590.1|WP_083092438.1|1466790_1467111_+|hypothetical-protein
MRTFIRQFVVIVMLAFASMAAVTLMTPAVSKADCADGEWWDPTGKVCRPLGVGPQPLACDPGQWWDPTANVCRPLGVGPQPLACDNGWWWDPGANECRPPVAPPAG
>NZ_AP022590.1|WP_083092415.1|1477586_1477829_-|hypothetical-protein
MLPIDPTADRGRRAWLPCPSCDHGATCGECRSSRNCDTHWQYLLSNRGTLVHLQCSDCGHLWSTDTHRRTRPKRWSHKLN
>NZ_AP022590.1|WP_169926933.1|1477815_1478046_-|hypothetical-protein
MADLDFAYDLTLDEARRRSAMLEAIGDDWDPIAVLREEEKAYDMLYSNLDEEQQRVYDELVHAGVLPERTIARATD
>NZ_AP022590.1|WP_083092412.1|1479204_1480212_-|GTP-binding-protein
MAAIPVIALTGHLGAGKTTLLNHLLRHPGTRIGVVVNDFGDINIDAGLVAGQVDEPASIAGGCICCLPDGGELDDALIKLADPARRLDAIVVEASGLADPVAIARLIGFSEIRGVRPGGLVDVVDAVNHFDTVDCGTLPPVRYGAASLIVVNKLDQVPERERAAVVQRVTQRAAQRNPCIHVVGTTGGRIAPELLFDASATSIQVGQLSFLDLVPEHDHDRVHVDAVTVSSSGCVDPDALLDLLENPPPRVFRLKGLVAVRHRTAVHGYVVNLVGNAIHIGTAPRGAITNCLVAIGMDLDVEAVRAGVDSALQPASGRASAQALRRLDRYRRLSA
>NZ_AP022590.1|WP_083092410.1|1480353_1480983_+|TetR/AcrR-family-transcriptional-regulator
MPRPRMHDPDVVLDAVEDLVARSGPTAVTIRAIGAAVGVSNGAVYHTFTSRGGLMGQAWLRAGKRFLSVQTSLVDEVVARGDQGGPIEAVVAAADAAVVFTEQYPGSSTLVLRVPRKQVLADDVPDDVADELRRLDKHLVALMVRLAIAMWDRKDAAAVDAITCCVVDLPTALLLRQDRLEGATARAQLHAAVRAVLAVGPPPPRQQRG
>NZ_AP022590.1|WP_083092407.1|1481024_1481696_+|enoyl-CoA-hydratase/isomerase-family-protein
MTVTLDYADKIAIVHLGEDENRFSPTFLDDIDDALDQAVSAGAQGLITTAAGKFYSNGLDLDWLSANTDRAQWYIGRVHRLLARMLTLPLPTAAAVVGHAFGAGAMLAIAHDFRVMRADRGYFCFPEVDIRIPFNPGMAALIQAKLTPRAAVASMTTGRRFSGPDAEHFGIVDATCAEGAVNDTALDVLRPLRGKDPGTLAAIKETMFDHAVRTLNDDDNGAQ
>NZ_AP022590.1|WP_083092405.1|1481769_1482696_+|alpha/beta-hydrolase
MANRLPDNAFTSPQALDPGLRKVARFVPRGYALHHGLKFQRAVMNLMGNAGRIRTVPVAAVNAHVAVRLHRPPGLPERAPALLWVHGGGTIMGHAAQDDKFLRKLSRRTGFAIAAVEHRLAPEHPYPTPVEDCYAALLWLARQPWVDPDRVAVGGASAGGNFAAAVAQRAHDRNDVQIAFQMLVYPMLDDRTGAERNGPRRIMWTESDNQLAWQWYLNGADPEEAAPARRTDLSGLPPAWIGVGTLDLFYQESQEYAQRLRDAGVPVQEEIVPGAFHAFDQIADKAPISTRFFESQCEYLRGALAPSG
>NZ_AP022590.1|WP_083092403.1|1482904_1483513_+|TetR-family-transcriptional-regulator
MANPVGLRERRRRQTSADIRDAAVRLTLKRGFDKVTVDEICAEAGIATRTFFNYFPNKESAIAYGPSDIPPELVEDFVAAGPAPYSVVLAELITLAAHHLRDVPPRREHAAHMLELAKTSPAVLAAFLADLERFQNQLTDIIVRRQAMEPDDEMAALISALALTAVRSGIEKWARGEATETADTPMPYVERAAALVNSIFTK
>NZ_AP022590.1|WP_083092401.1|1483826_1484243_+|hypothetical-protein
MRNAWLPLLIVAVLVVGGFAVVRVKSFFGAHDTGIMTSPRLDDSKPFKPKVVKYEVFGSADQANVNYLDLSADPRRVDGAPLPWTLVLSTTAPSVFPNLSAQSDGSSLGCRITIDDEVKAENITHGVHALTFCLVKSA
>NZ_AP022590.1|WP_083092399.1|1484239_1487140_+|MMPL-family-transporter
MSTTVDDTRTDAIPVVKEPVHDKIPRIIRTLAVPIIVGWVALIAVLNVVVPQLDEVGKMRSVSMAPDDAQSVVATKRMGAIFNEYKSNSSVMIVLEGQNPLGADAHAYYDQIVKKLDADTKHVEHVQDMWSDPLTGAGAQSNDGKAAYVQVYLAGNQGEALANESVESVQKIVKSVPTPKGVKVYVTGPAALSADQHEAGDRSLQLITAATFTVIIGMLLLVYRSIVTVLLTLVMVVLELSAARGMVAFLGYFNLIGLSTFATNLLVTLGIAAATDYAIFLIGRYQEARAVGESREEAYYTMYKGTAHVVLGSGLTIAGATFCLHFTNLPYFQTLGIPLAIGMVVVVAAALTLGPAVISVATRFGKTLEPKRTQRIRGWRKIGALVVRWPGPILVMTIGVALVGLLTLPGYRTNYNDRNYLPADLPANEGYAAADRHFSQARMNPEVLMIESDHDLRNSADFLVIDKIAKTVFRVPGIARVQAITRPQGTPIEHTSIPFQISMQGVTQQMNQKYQEDQMADMLHQADMMQTTIDSMEKMSSITVQMSNDMHQMVKKMHDMTIDINELRDHMADFEDFFRPIRSYLYWEKHCYDIPVCWSLRSVFDGLDGIDTMTDDIQSLLPIMDHLDTLMPQMVALMPSMIANMKAMKTTMLTMYSTQKGLQDQQNEAQKNSNAMGKAFDASKNDDSFYLPPETFNNAEFKKGMKNFISPDGHAVRFIISHDGDPMSQEGISHIPAIKKAAYEALKGTPLEGSKIYLAGTASIYKDLSDGNTYDLLIAGIASLCLIFIIMLIITRGVVASAVIVGTVLLSLGASFGLSVLIWQHLIGIELHWMVLAMSVIILLAVGADYNLLLVARFKEEIHAGLNTGIIRSMGGTGSVVTSAGLVFAFTMMTMAVSELTVIGQVGTTIGLGLLFDTLIVRSLMTPSIAALLGKWFWWPQRVRQRPVPSPWPQPAKDRESFADAR
>NZ_AP022590.1|WP_083092397.1|1487221_1488004_-|glucose-1-dehydrogenase
MAERLAGKVALISGGARGMGASHVRSLVAEGAKVVFGDILDDEGKAVAAEVGDAVRYLHLDVTKPEDWDAAVTTALGEFGHLDVLVNNAGIINIGTLEDYALSEWQRILDINLTGVFLGIRAVVKPMKEAGRGSIINISSIEGMAGTIACHGYTATKFAVRGLTKSAALELGPSGIRVNSIHPGLIKTPMTDWVPDDIFQTALGRAAQPVEVSHLVVYLASDESSYSTGSEFVVDGGTTAGLGHKDFSNVETDAQPDWVT

Crispr_ID: NZ_AP022590_7

• CRISPR_ID: NZ_AP022590_7
• CRISPR_location: 1602603-1602694
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP022590_7

Consensus_repeat	Method
GAGCGCGGCCGCGAACTCGCCAGCAC	CRISPRCasFinder

spacers of NZ_AP022590_7

>7.1|1602629|40|NZ_AP022590|CRISPRCasFinder
CGCTGCCGAACGCGGCGCACCCTACGCCGAAGCCGCGCTG

CRISPR arrays and Neighbor proteins around NZ_AP022590_7

CRISPR arrays

The CRISPR arrays of NZ_AP022590_7

>merge|NZ_AP022590|7|1602603-1602694|CRISPRCasFinder
GAGCGCGGCCGCGAACTCGCCAGCACCGCTGCCGAACGCGGCGCACCCTACGCCGAAGCCGCGCTGGAGCGCGGCCGCGAACTCGCCGGCAC

>NZ_AP022590|7|7|1602603-1602694|CRISPRCasFinder
GAGCGCGGCCGCGAACTCGCCAGCAC	CGCTGCCGAACGCGGCGCACCCTACGCCGAAGCCGCGCTG
GAGCGCGGCCGCGAACTCGCCGGCAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022590.1|WP_067826524.1|1603686_1604076_-|hypothetical-protein	unknown	unknown	gnl|CDD|314732
NZ_AP022590.1|WP_083092245.1|1600234_1600585_+|DoxX-family-protein	unknown	unknown	gnl|CDD|379266
NZ_AP022590.1|WP_083092252.1|1595965_1596808_-|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472
NZ_AP022590.1|WP_083092237.1|1604635_1606657_-|phosphotransferase	unknown	unknown	gnl|CDD|367273
NZ_AP022590.1|WP_142275400.1|1608939_1609911_-|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|187611
NZ_AP022590.1|WP_083092254.1|1594892_1595963_-|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC	unknown	unknown	gnl|CDD|236947
NZ_AP022590.1|WP_142275393.1|1596794_1597739_-|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|224096
NZ_AP022590.1|WP_083092615.1|1600606_1601404_-|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl|CDD|366932
NZ_AP022590.1|WP_083092248.1|1597759_1599085_-|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270303
NZ_AP022590.1|WP_083092246.1|1599142_1600069_-|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|236600
NZ_AP022590.1|WP_083092229.1|1611879_1612515_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083092258.1|1593531_1593819_+|DUF3349-domain-containing-protein	unknown	unknown	gnl|CDD|371747
NZ_AP022590.1|WP_083092612.1|1608287_1608950_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083092231.1|1611237_1611867_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NZ_AP022590.1|WP_083092232.1|1609921_1611145_-|cytochrome-P450	unknown	unknown	gnl|CDD|225035
NZ_AP022590.1|WP_083092613.1|1601406_1601967_-|pyrazinamidase-PncA	unknown	unknown	gnl|CDD|238493
NZ_AP022590.1|WP_083092256.1|1593843_1594809_-|patatin-like-phospholipase-family-protein	unknown	unknown	gnl|CDD|132846
NZ_AP022590.1|WP_083092241.1|1603077_1603656_-|zeta-toxin-family-protein	unknown	unknown	gnl|CDD|226648
NZ_AP022590.1|WP_083092235.1|1606675_1608193_-|carboxylesterase/lipase-family-protein	unknown	unknown	gnl|CDD|225181
NZ_AP022590.1|WP_083092239.1|1604144_1604639_-|gluconokinase	unknown	unknown	gnl|CDD|225804

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP022590.1|WP_067826524.1|1603686_1604076_-|hypothetical-protein	gnl|CDD|314732	pfam11903, ParD_like, ParD-like antitoxin of type II bacterial toxin-antitoxin system. ParD-like antitoxin is a family of archaeal and bacterial proteins of a type II bacterial toxin-antitoxin system. Many of the cognate toxins for these molecules fall into family ParE-like_toxin, pfam15781. Gene-pairs are expressed from the same operon, the toxin of the pair being expressed first, eg, for UniProtKB:Q3AQ93 and UniProtKB:Q3AQ94.	5.37048e-15
NZ_AP022590.1|WP_083092245.1|1600234_1600585_+|DoxX-family-protein	gnl|CDD|379266	pfam13564, DoxX_2, DoxX-like family. This family of uncharacterized proteins are related to DoxX pfam07681.	3.03303e-11
NZ_AP022590.1|WP_083092252.1|1595965_1596808_-|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	3.4683e-88
NZ_AP022590.1|WP_083092237.1|1604635_1606657_-|phosphotransferase	gnl|CDD|367273	pfam02958, EcKinase, Ecdysteroid kinase. This family includes ecdysteroid 22-kinase, an enzyme responsible for the phosphorylation of ecdysteroids (insect growth and moulting hormones) at C-22, to form physiologically inactive ecdysteroid 22-phosphates.	9.33192e-25
NZ_AP022590.1|WP_142275400.1|1608939_1609911_-|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|187611	cd05353, hydroxyacyl-CoA-like_DH_SDR_c-like, (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs. Beta oxidation of fatty acids in eukaryotes occurs by a four-reaction cycle, that may take place in mitochondria or in peroxisomes. (3R)-hydroxyacyl-CoA dehydrogenase is part of rat peroxisomal multifunctional MFE-2, it is a member of the NAD-dependent SDRs, but contains an additional small C-terminal domain that completes the active site pocket and participates in dimerization. The atypical, additional C-terminal extension allows for more extensive dimerization contact than other SDRs. MFE-2 catalyzes the second and third reactions of the peroxisomal beta oxidation cycle. Proteins in this subgroup have a typical catalytic triad, but have a His in place of the usual upstream Asn. This subgroup also contains members identified as 17-beta-hydroxysteroid dehydrogenases, including human peroxisomal 17-beta-hydroxysteroid dehydrogenase type 4 (17beta-HSD type 4, aka MFE-2, encoded by HSD17B4 gene) which is involved in fatty acid beta-oxidation and steroid metabolism. This subgroup also includes two SDR domains of the Neurospora crassa and Saccharomyces cerevisiae multifunctional beta-oxidation protein (MFP, aka Fox2). SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	4.66208e-91
NZ_AP022590.1|WP_083092254.1|1594892_1595963_-|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC	gnl|CDD|236947	PRK11650, ugpC, sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC.	1.1818e-180
NZ_AP022590.1|WP_142275393.1|1596794_1597739_-|ABC-transporter-permease-subunit	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.5689e-93
NZ_AP022590.1|WP_083092615.1|1600606_1601404_-|nuclear-transport-factor-2-family-protein	gnl|CDD|366932	pfam02136, NTF2, Nuclear transport factor 2 (NTF2) domain. This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.	3.92006e-11
NZ_AP022590.1|WP_083092248.1|1597759_1599085_-|sugar-ABC-transporter-substrate-binding-protein	gnl|CDD|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.86988e-72
NZ_AP022590.1|WP_083092246.1|1599142_1600069_-|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|236600	PRK09636, PRK09636, RNA polymerase sigma factor SigJ; Provisional.	4.61139e-51
NZ_AP022590.1|WP_083092258.1|1593531_1593819_+|DUF3349-domain-containing-protein	gnl|CDD|371747	pfam11829, DUF3349, Protein of unknown function (DUF3349). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 99 to 124 amino acids in length.	3.16598e-28
NZ_AP022590.1|WP_083092232.1|1609921_1611145_-|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	3.15519e-77
NZ_AP022590.1|WP_083092231.1|1611237_1611867_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	9.47597e-10
NZ_AP022590.1|WP_083092613.1|1601406_1601967_-|pyrazinamidase-PncA	gnl|CDD|238493	cd01011, nicotinamidase, Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).	9.53848e-69
NZ_AP022590.1|WP_083092256.1|1593843_1594809_-|patatin-like-phospholipase-family-protein	gnl|CDD|132846	cd07207, Pat_ExoU_VipD_like, ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2. ExoU, a 74-kDa enzyme, is a potent virulence factor of Pseudomonas aeruginosa. One of the pathogenic mechanisms of P. aeruginosa is to induce cytotoxicity by the injection of effector proteins (e.g. ExoU) using the type III secretion (T3S) system. ExoU is homologus to patatin and also has the conserved catalytic residues of mammalian calcium-independent (iPLA2) and cytosolic (cPLA2) PLA2. In vitro, ExoU cytotoxity is blocked by the inhibitor of cytosolic and Ca2-independent phospholipase A2 (cPLA2 and iPLA2) enzymes, suggesting that phospholipase A2 inhibitors may represent a novel mode of treatment for acute P. aeruginosa infections. ExoU requires eukaryotic superoxide dismutase as a cofactor and cleaves phosphatidylcholine and phosphatidylethanolamine in vitro. VipD, a 69-kDa cytosolic protein, belongs to the members of Legionella pneumophila family and is homologus to ExoU from Pseudomonas. Even though VipD shows high sequence similarity with several functional regions of ExoU (e.g. oxyanion hole, active site serine, active site aspartate), it has been shown to have no phospholipase activity. This family includes ExoU from Pseudomonas aeruginosa and VipD of Legionella pneumophila.	6.35832e-66
NZ_AP022590.1|WP_083092241.1|1603077_1603656_-|zeta-toxin-family-protein	gnl|CDD|226648	COG4185, COG4185, Uncharacterized protein conserved in bacteria [Function unknown].	5.06504e-67
NZ_AP022590.1|WP_083092235.1|1606675_1608193_-|carboxylesterase/lipase-family-protein	gnl|CDD|225181	COG2272, PnbA, Carboxylesterase type B [Lipid metabolism].	0
NZ_AP022590.1|WP_083092239.1|1604144_1604639_-|gluconokinase	gnl|CDD|225804	COG3265, GntK, Gluconate kinase [Carbohydrate transport and metabolism].	5.16882e-71

Protein sequences

>NZ_AP022590.1|WP_083092613.1|1601406_1601967_-|pyrazinamidase-PncA
MRALIIVDVQNDFCEGGPVPTADGAAVAPAINAYLSGDPGYRYIVATQDFHIDPGDHFSDRPDYSSSWPVHCVAGSVGANLRPDLNTGYLDAVFRKGAYSAAYSGFEGVDENGTTLLQWLRQRGVDEVDVVGIATDFCVRRTAEDAAAAGLTTRVLVDLTAAAAADSGAEALAEMRSAGIELVGGP
>NZ_AP022590.1|WP_083092615.1|1600606_1601404_-|nuclear-transport-factor-2-family-protein
MVPLDRQHLLAAVERSPQAAAAHDRAGWVGLFTADGRVEDPVGSRPHVGHEQIGRFYDTFIGPRDIKFHRDLDIVVGTAVLRDLELEVAMGSAVTMYIPAFLRYDLRETNGEWKIGQLRAYWELPAMMLQFLRTGSGALRPALNLSKALLGNQGWRGTAGFVTGFRRVGARHQRLVTTFLGAAARNDKFSAARALSSDAALTLGDRDPLDLAELVEQLDGAGATKMISAGPTVAVSLNSGHGRAIVFADVAWGGDAVTRIRYFPA
>NZ_AP022590.1|WP_083092245.1|1600234_1600585_+|DoxX-family-protein
MNTALVATTLVTAAVTAAIAVADLIPARFVLANSAQVGVPRSWLPALGGLKLAGAAGILIGLLGLRELGIAAAAGLVLFFVGAVVTHVRAHVLYNIAFPGAYLCLSAASLALMVMR
>NZ_AP022590.1|WP_083092246.1|1599142_1600069_-|sigma-70-family-RNA-polymerase-sigma-factor
MSATHDLVELAQRFDADRRHLRSVAFQLLGSTADADDAVQSAWLKASRADFAAVDNLSGWFTTITVREAFDQLRVRKRRAEQSFAEADELDRLARTASAPADEDALLTESVSGALLVVLDRLSPAQRVAFVLHDVFAMPFDQIAAATNRSPDAVKKLASRARARLHAASATRPRRTAHHLKVVEAFLTASRGGDIAVLLHLLAPEVLRTVDRALVPADVPTALRGAREVAEETRRFAQRARAGAVMLIDGAPGIVIAARGRAQILLVIGIGADDRIHTIDITGDAERIRLAALTLPRWPTQEHHNLIG
>NZ_AP022590.1|WP_083092248.1|1597759_1599085_-|sugar-ABC-transporter-substrate-binding-protein
MLDKPFGRRSLLRGAGALCAAALAPWPAGCAPDDDALTFFFAANPDERDARMRIVDEFARRHPDIKVRPVQSGPGVMQQLSTFCVGGRCPDVLMAWELSYAELAERGVLLDMNTLLARDKAFADELKADSIPALYETFTFNEKQYALPEQWSGNYLFYNKRLFAEAGVPAPPKTWEQPWDFTEFLDAARALTKRDASGRAAQYGFVNTWGSYYSAGLFAMNNGVAWSDPRLNPTHFNFDKAAFQEAVQFYADLANKYRVAPNASETQSMSTPNLFAVGRAAIALGGHWRYQTYIRAEDLDFDVAPLPVGPALGKGHAACSDIGATGLAISASSPRKEQAWEFVKFATGPIGQALIGESCLFVPVLRSALGSDGFAKAHRRLGNLGVLTEGPAYSQGLPITPAWEKVNALMDRNFGPVLRGSQPAASLSGLSRSVDEVLRSP
>NZ_AP022590.1|WP_142275393.1|1596794_1597739_-|ABC-transporter-permease-subunit
MTATAGRATAKSPKNPSPWRRHAWAGRLFVAPNMVAVAVFMLFPLGFSLYMSFQRWDVFTPPKFVGLNNFGDLFTADPLFLIAIRNTVIFTLGTVVPTVLISLAVAGVLNQKVRGIGIFRTIVFLPLAISSVVMAVVWQFVFNTDNGLLNIMLGWVGLGPVPWLVDPHWAMASLCIVSVWRSVPFATVVLLAAMQGVPGTVYEAAKIDGASEIRQFVSITVPLIRGSISFVVIISVIHAFQAFDMVYVLNGPSGGPESATYVLGIMLFQHAFSFLEFGYASALAWVMFAVLLVLTVVQLRVSHRRSLENSRGLK
>NZ_AP022590.1|WP_083092252.1|1595965_1596808_-|carbohydrate-ABC-transporter-permease
MASSRAVFKHTVLRGSVVYGALLGVAWCALFPIAWAVSGSLKTEGEVSEPTLLPAHPRWSNYTEVFALMPFGRMFFNTVLYAGCVTTGHVFFCSLAGYAFARLDFRGRDALFVVYLGTLMVPLTVTVIPQFLVMRTLGWVDTPWAMIVPGFFGSAFGTYLMRQFFRTLPTDLEEAAILDGCSPWQVYWRILLPHARPAVMVLAVLTWVNVWNDFLWPLLMIQRNSLATLTLGLVRMKGEYVARWPVLMATSMLIMLPLVIIYAIAQRSFVRGIAVTGMGG
>NZ_AP022590.1|WP_083092254.1|1594892_1595963_-|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC
MASVTFEQATRRYQGADRPALDNLDLHVGDGEFVVLVGPSGCGKTTSLRMVAGLEVVDSGHIRIGDRDVTHVDPKDRDVAMVFQNYALYPHMTVAQNMGFAMKIAKTPKAQIRERVLDAAKLLDLQAYLDRKPKDLSGGQRQRVAMGRAIVRRPQVFLMDEPLSNLDAKLRVQTRNQIAALQRRLGTTTVYVTHDQVEAMTMGDRVAVLRDGVLQQFAPPRELYRNPDNVFVAGFIGSPAMNLFTLPIVDCAVSLGDWPIILPREIAGSAGEVVVGVRPEHFELGDLGVEMEVDVVEELGADAYLYGRITGPGKVIDAPIVARADGRHPPQKGSRVRLHPEPGHLHFFGVDGRRIC
>NZ_AP022590.1|WP_083092256.1|1593843_1594809_-|patatin-like-phospholipase-family-protein
MSADRADLVCEGGGVRGIGLVGAVDALARAGYRFPRVAGSSAGAIVASLVAALQVAGEPLSRLTDVMRTIDYRKFLDRNLIGRVPLIGGALSLLTSDGVYRGAYLEQLLAGLLRDLGVRTFGDLRTGEEPEQFAWSLVVTASDLSRRRLVRIPWDLDSYGIDPDDFPVARAVHASSAIPYVFEPVRVGGATWVDGGLLSDFPVELFDRPDAQPRWPTFGIRLSARPGIPPTHPVHGPVSLGIAAIETLVSNQDNAYIDDPCTVRRTIFVPAEGISPIDFDITTQQREALYERGLQAGQQFLQTWNYADYLAVCGAPVHKSP
>NZ_AP022590.1|WP_083092258.1|1593531_1593819_+|DUF3349-domain-containing-protein
MDLSHWVTSIVAFVRAGYPSGMPVTGYVPLVALTRRRLGDDDITAIATDLIARRLRPISPVDIGVEITRITNQLPSPDDVSRVHRRVHALRCSRG
>NZ_AP022590.1|WP_083092241.1|1603077_1603656_-|zeta-toxin-family-protein
MDRLDLVVGPNGAGKSTFIAFTLAPLLPGSLVVNADEIARQRWPQDAAAHSYDAARIAADTRAKLIDLGRSFIAETVFSHPSKLDLIHAARRAGFTVVLHVVVIPEDLAVERVRHRVRAGGHDVPEGKIRQRHRRLWTPVAEAIALSDLTTVYDNSRLRGPCIIARLSGGLTIGKPDWPAWAPEILRSRWPN
>NZ_AP022590.1|WP_067826524.1|1603686_1604076_-|hypothetical-protein
MAEALDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEISAAIEESLARTNYGATLAGQGVTTVALNDDGEIVEYRPDGAAVVLAGGR
>NZ_AP022590.1|WP_083092239.1|1604144_1604639_-|gluconokinase
MSGSAPVVVMGVSGSGKSTVGAALAQRLRVPFVDADTLHPAANIAKMAAGEPLDDGDRYPWLERVGEWLAAHRDGAVVSCSALKRKYRDQLRAHCPGMEFLHLSGSAELIGGRLAARTDHFMPVALLRSQLDTLEPLGSDEAGMTVDVGRGVDAIVDAVVKARE
>NZ_AP022590.1|WP_083092237.1|1604635_1606657_-|phosphotransferase
MHAETEQVIERPSDLSATWLAAVIGTGPIADFSVERIGTGQMSECYRIRLSYAEAEGTANGPESVVLKVAATDPVSRQTGLALGLYEREVRFYGDIAPRLGGPVTPCYHAAVDTSTGVFDLLLGDAGPAVVGDEIAGATVEQARLGVVELGRLHGPLLGDPSLAEAPWFNREAPLNQAMITPLYAGFADRYGDQIAPEHRVVCERLVAAFDGYLAQEAEASGPGRIQGLVHGDYRLDNMLFGTEGADRALTVVDWQTVSWGPALTDLAYFLGCALATEDRRQHYDALLRAYHEALGPEAPLTLTDVADGVRRQSFFGVMMAIVSSMLVERTDRGDQMFMTMLRRHCDHVLDTDALSTLPAAVAPEPLQPSPEDELAHDPTAEPLWSESWYADFADAAQGLGGWFRLGRVANERTAWVHVLLCGPDMPTVAVDAQVTLPPDPWAVRTDDFELVHAADTPLQSYRVDVRARGQAYADPSALLAGEPGTPVEMTMNLVWATDGTPYKYGLTTRYEIPCTVSGSVTIDGTGYRVDAVPGQRDHSWGVRDWWGMDWMWSALHLHDGTHLHAVNIRIPGAPAFSIGYEQGADGKVTELQTVDSRESFAGNGLPLDATLVLEPGAITANVDVRGQAPVRLVATDGRVSQFPRVWATISTADGRSGVGWLEWNRNLGERTG
>NZ_AP022590.1|WP_083092235.1|1606675_1608193_-|carboxylesterase/lipase-family-protein
MHDRTVRARTAIGTVEGFTRDGVNRWRSIPYARPPVGRLRFRAPQPALPWSGVRHCHGFGNCAPQQRRYTLLGMSGLGGRYQPMSEDCLTLNVVAPEGDAEGPLPVMVFIHGGGYFLGSSATPLYDGAALARRGCVYVSVNYRLGALGCVDFSSLSTPETTIDSNLYLRDLVLALQWVRDNIAGFGGDPDNVTIFGESAGACITASLLAVPAAQGLFARAISESPASGLVRSKEVAAEFANRFANLLGVRKQDAANALMQASSAQLVETQHRLIDEGMQKRLGAFPIGPVFGDDILPRDPVEAMRRGEAHRVPLIVGTNAEEGRLFTRFLAMLPTNETMVEELLAEAEPAVRERITAAYPDYPERAACIQLGGDFAFASAAWQIAEAHGTHAPTYLYRYDYAPRTLRWSGFGATHATELLAVFDVYRTRFGALLTAAADRRGALRVSNQVQRRWRAFSRTGVPGEDWPLYTADERAVMVFDRKSRVEFDPHPHRRMAWDGFSLAH
>NZ_AP022590.1|WP_083092612.1|1608287_1608950_+|hypothetical-protein
MIAASLLVAGCSHTTGGGGPSQTPNTTQVSGFSPTNTPSGSAPAGAPSAKAPISDVIAWIEAGHPADPGRFHTATREGTATPLGDDIALTAMAGKVSCMTDAKRTGNALECLVSLTNPPPAPATAYGQWHGGWISFDGVNLQVGSARADPGPFINGNGSELANGDSLSFGDYRCRADQAGLYCVNYAHQSAAKFSPAGIEPFGCLKSTPPPDGVGTAFSC
>NZ_AP022590.1|WP_142275400.1|1608939_1609911_-|SDR-family-NAD(P)-dependent-oxidoreductase
MPTSELRFDDQVAVITGAGGGLGRQYALLLASRGARIVVNDIGGSVTGNGSDAAAAGAVADEIRELGGEAVADSHSVTDPEGARSIIDAALNVWGRVDIVINNAGIVGDALFEDMTADRFEPLLDVHLKGACYVTRPAWKVMCEQGYGRILNTCSAAGILGATGMSNYGSAKTGLIGLTRVLAAEAAGRDIKVNAIAPIAYTRMLAHSVDGAVRPDDADAQVVLDDLVGQYLQKLDPALVAPVAAFLTHRDCPVSGEIYTVGAGHVSRFFIGRTKGFYSPALSVEDVRDHLNDIRDEAGYTVPGGPGDEMSELFATIMAGLSS
>NZ_AP022590.1|WP_083092232.1|1609921_1611145_-|cytochrome-P450
MSISFETTDSCSDADLPVLPIPRAAQCPLAPPADFADWRERPGLQRAMFQGNPVWVVSRYRDIRAALVDPRLSAKTIPDSIMPTDADNKVPVMFARTDDPEHHRLRRMMTGNFTFRRCESMRPHIQDMVDHYLGQMIDNGAPADLVREFALPVPSMVIALLLGVPPEDLELFQHNTTTGLDQKSTDAQKGQAFGAMYAYIEELVERKEREPGDDLISHLLTEYVATGQLDHATTAMNSVIMMQAGHETTANMISLGTVALLEHPDVFERLGQTDDPAVIANVVEELMRYLTIVHSQVDRVATEDLMIGGQLIRAGEFVMMSLLAGNWDTEFVDHPESLDVDRNTRGHLGFGYGVHQCIGANLARVEMQVAFATLARRLPGLKLAVPASELQFKKANIYGMKELLVSW
>NZ_AP022590.1|WP_083092231.1|1611237_1611867_+|TetR/AcrR-family-transcriptional-regulator
MTAVEDRPLRADAARNVERILRAAREVYAESGPDAPVEAVARRAGVGERTLYRRFPAKADLVRAALDQSIAEDLTPVIDRARLAKDPLRGLTELIEAAISLGAREHHLLTAARRAGSLTSDISVSLNAALGDLARAGQRAGSIRADLVTDDLPRLVAMLFGVLSTMDADSDGWRRYVALIIDAISVNERQPLPPATALRYEVQPDSWPL
>NZ_AP022590.1|WP_083092229.1|1611879_1612515_-|hypothetical-protein
MNTVRTSALGLTATAVLIGATVVGCGGDKGSTASSGSAASSSSAASSTPSAGAAPASPGAPADYSNLLIKPSDIGPNATADGPPSQNPSGIAGVGQVFKNPDGKRTIVDTIAVFPDAGTAAQTAANMRDVVGKKVNGQQQPIDLGTNGFMVIGQGSDPANPMEISEAVFVEGRAMVDLESDCVIGNPTPADVMLDLARKQDAAIKAGLPAS

Crispr_ID: NZ_AP022590_8

• CRISPR_ID: NZ_AP022590_8
• CRISPR_location: 1796564-1796667
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP022590_8

Consensus_repeat	Method
AAACCGCAGGTCAAGCGATCACGC	CRISPRCasFinder

spacers of NZ_AP022590_8

>8.1|1796588|56|NZ_AP022590|CRISPRCasFinder
CCCCCTCTCCACCAGAAACCGATCACGAACCGACCACGCCGATCACGCTTCGGGCA

CRISPR arrays and Neighbor proteins around NZ_AP022590_8

CRISPR arrays

The CRISPR arrays of NZ_AP022590_8

>merge|NZ_AP022590|8|1796564-1796667|CRISPRCasFinder
AAACCGCAGGTCAAGCGATCACGCCCCCCTCTCCACCAGAAACCGATCACGAACCGACCACGCCGATCACGCTTCGGGCAAACCCGCAGGTCAAGCGATCACGC

>NZ_AP022590|8|8|1796564-1796667|CRISPRCasFinder
AAACCGCAGGTCAAGCGATCACGC	CCCCCTCTCCACCAGAAACCGATCACGAACCGACCACGCCGATCACGCTTCGGGCA
AACCCGCAGGTCAAGCGATCACGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022590.1|WP_163650825.1|1789311_1790691_-|DUF222-domain-containing-protein	unknown	unknown	gnl|CDD|367155
NZ_AP022590.1|WP_142275728.1|1796808_1797201_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083098765.1|1800074_1800920_+|hypothetical-protein	unknown	unknown	gnl|CDD|319971
NZ_AP022590.1|WP_083098725.1|1798928_1799213_+|HNH-endonuclease	unknown	unknown	gnl|CDD|366837
NZ_AP022590.1|WP_083098711.1|1790984_1791515_-|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	unknown	unknown	gnl|CDD|224793
NZ_AP022590.1|WP_083097730.1|1788537_1789020_+|GreA/GreB-family-elongation-factor	unknown	unknown	gnl|CDD|234693
NZ_AP022590.1|WP_083098763.1|1795146_1795440_+|DUF2742-domain-containing-protein	unknown	unknown	gnl|CDD|371285
NZ_AP022590.1|WP_083098724.1|1797928_1798780_+|phage-major-capsid-protein	unknown	unknown	gnl|CDD|273690
NZ_AP022590.1|WP_142275736.1|1794910_1795111_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|378935
NZ_AP022590.1|WP_142275730.1|1799718_1800027_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083098714.1|1793149_1794298_-|site-specific-integrase	unknown	unknown	gnl|CDD|271189
NZ_AP022590.1|WP_083098716.1|1794284_1794776_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|238045
NZ_AP022590.1|WP_083097731.1|1787926_1788541_+|GreA/GreB-family-elongation-factor	unknown	unknown	gnl|CDD|234693
NZ_AP022590.1|WP_142275732.1|1801920_1802250_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083098731.1|1800924_1801386_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_142275731.1|1801389_1801575_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_169926979.1|1795559_1796531_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|316042
NZ_AP022590.1|WP_142275729.1|1799346_1799715_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083098722.1|1797197_1797782_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083098713.1|1791551_1792907_-|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl|CDD|181163

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP022590.1|WP_163650825.1|1789311_1790691_-|DUF222-domain-containing-protein	gnl|CDD|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	9.16261e-89
NZ_AP022590.1|WP_083098765.1|1800074_1800920_+|hypothetical-protein	gnl|CDD|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	2.36899e-14
NZ_AP022590.1|WP_083098725.1|1798928_1799213_+|HNH-endonuclease	gnl|CDD|366837	pfam01844, HNH, HNH endonuclease. His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.	2.92628e-11
NZ_AP022590.1|WP_083098711.1|1790984_1791515_-|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	gnl|CDD|224793	COG1881, COG1881, Phospholipid-binding protein [General function prediction only].	1.33428e-62
NZ_AP022590.1|WP_083097730.1|1788537_1789020_+|GreA/GreB-family-elongation-factor	gnl|CDD|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	2.69284e-21
NZ_AP022590.1|WP_083098763.1|1795146_1795440_+|DUF2742-domain-containing-protein	gnl|CDD|371285	pfam10888, DUF2742, Protein of unknown function (DUF2742). Members in this family of phage proteins are the product of the gene phiRv1, however no function is known.	1.57265e-24
NZ_AP022590.1|WP_083098724.1|1797928_1798780_+|phage-major-capsid-protein	gnl|CDD|273690	TIGR01554, prophage_Lp3_protein_18, phage major capsid protein, HK97 family. This model family represents the major capsid protein component of the heads (capsids) of bacteriophage HK97, phi-105, P27, and related phage. This model represents one of several analogous families lacking detectable sequence similarity. The gene encoding this component is typically located in an operon encoding the small and large terminase subunits, the portal protein and the prohead or maturation protease. [Mobile and extrachromosomal element functions, Prophage functions].	1.98389e-13
NZ_AP022590.1|WP_142275736.1|1794910_1795111_+|helix-turn-helix-domain-containing-protein	gnl|CDD|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	2.57287e-06
NZ_AP022590.1|WP_083098714.1|1793149_1794298_-|site-specific-integrase	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.16942e-34
NZ_AP022590.1|WP_083098716.1|1794284_1794776_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.69223e-06
NZ_AP022590.1|WP_083097731.1|1787926_1788541_+|GreA/GreB-family-elongation-factor	gnl|CDD|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	4.13941e-16
NZ_AP022590.1|WP_169926979.1|1795559_1796531_+|AAA-family-ATPase	gnl|CDD|316042	pfam13481, AAA_25, AAA domain. This AAA domain is found in a wide variety of presumed DNA repair proteins.	1.6658e-07
NZ_AP022590.1|WP_083098713.1|1791551_1792907_-|M20/M25/M40-family-metallo-hydrolase	gnl|CDD|181163	PRK07906, PRK07906, hypothetical protein; Provisional.	0

Protein sequences

>NZ_AP022590.1|WP_169926979.1|1795559_1796531_+|AAA-family-ATPase
MDGGSFIFDEPADIPAVWGSGGQVLWAEGESLMIAGQQGLGKTTLAGRIVRARLGLGDGTVLGLPVAPTDRPALYLAMDRPRQIARAMRRQFNEDERDVLAERLIVRRGPPPADLAAHPTLLAAMSEYYGAATVIVDSLKDAALGLSNDEVGAAWNRARQHLLAAGCQLCELHHCVKRGPNGGEIKDINDVYGSAWLTNGCGSVILLTGAPGDPVVGFRHVKQPAEEAGPWQLLHDQDAGQMTVKHSFDLIALVKATGADGLTAKGAAAAIFQKREPSSAEVEKARRKLMKLETERLLVRLAGAKGGADGGTAVAWFLADWGH
>NZ_AP022590.1|WP_083098763.1|1795146_1795440_+|DUF2742-domain-containing-protein
MSWWAVHEFVAAVLDQVNGWPMLGTPAWCSLAHDDPRKWAAVLDGGQHHALRLELNQEAHAEVSRAVSGAVDWSALAREINRRTDFYAARPWLRRAQ
>NZ_AP022590.1|WP_142275736.1|1794910_1795111_+|helix-turn-helix-domain-containing-protein
MEVNTPAQTAKFIQTSEGSLAQDRYRKRGIPFVKIGGRVRYLRQDILAYLDANRMQRTDDPRGGAA
>NZ_AP022590.1|WP_083098716.1|1794284_1794776_-|helix-turn-helix-transcriptional-regulator
MAGKEPDIGATSRTVAANVKRLREAMNMNFTQLSERLIATAGWSINAVGIRRLEAEERRVTPDDLVALAVALGVSPITLLMPVSHSGDDAVEATGVKSGVAAHQLWRWYQAAGQLHDGEYDEFLTFVARALPPWRQRQVELVESGIEPHVTRFVRERVGDGDD
>NZ_AP022590.1|WP_083098714.1|1793149_1794298_-|site-specific-integrase
MATIKRYQTAGGERWEVRYRQPNGVTSRKRGFTTKRDASAWASKVETSKAEGAYVSPARGRMTVGDLSAGWLARQEQALAPSYYRTISYAYGKHVGPKWAGVPVGKVDSLDVKAWAASMTRGGSSATVVNRAIGILAGILDDAVEHRALAFNPARKFKRGEKPKKSPKRHVYLTETDVCRLAEESGRHADLVLLLAFTGLRWGEAIALTVADVEFLKRRISVHRNAVQVGQEFEVGQTKGKENRTVPVAASVLSRLAVRCEGRAAADLLFPARSSGYLKRPSYDETGWFNRAVERADVQTITPHDLRHTCASLAVSSGANVLAVSRMLGHKDPSVTLRVYADLFDSDLDAVAVNLDAKIADSVQSVSKAPADRRRKRRITAV
>NZ_AP022590.1|WP_083098713.1|1791551_1792907_-|M20/M25/M40-family-metallo-hydrolase
MTIQSGATEVPTNSSDDVVEVVSKLIRFDTTNTGEPETTKGEADCAQWVAEKLAEVGYAPHYVESGAPGRGNVFVRLPGADSSRGALLIHGHLDVVPAEPTEWSVHPFSGAIKEGFVWGRGAVDMKDMVGMMIVVARQLKRAGIVPPRDLVFAFIADEEHGGTFGAQWLVDNRPELFTGVTEAIGEVGGFSLTVRRRDGGERRLYLIETAEKGLSWMKLTARGPAGHGSMVHDHNAVTAVAEAVARLGRHQFPLVLTDTVAQFLAAVSEETGLTFDTESGDLRGAIEKLGPMARMLKAVLHDTANPTMLKAGYKANVVPAIAEAVVDCRILPGRKADFEAEIDELLGPDVTREWIKDFSSYETGFDGDLVDAMNAAVLAFDPGARTVPYMLSGGTDAKSFARLGIRCFGFSPLRLPPDLDFTALFHGVDERVPIDALRFGTDVLAHFLTHC
>NZ_AP022590.1|WP_083098711.1|1790984_1791515_-|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein
MSTAPDPYASLPKLPTFTLTSQSVTDGQPLANPQVSGIMGAGGEDVSPQLSWSGFPDETRSFAVTVYDPDAPTASGFWHWAVANLPADVTELPAGAGDGSNLPGDALTLVNDAGQRRYIGAAPPAGHGAHRYYIAVHAVDTEKLDLPEDASPAFLGFNLFQHAIARAVIHATYEQK
>NZ_AP022590.1|WP_163650825.1|1789311_1790691_-|DUF222-domain-containing-protein
MTVTDREQIQDDVDTLCAVASRFEEHSYAALTNPERLGILEKLECVTRKLQTPRHQLINQVGEQSDSTELGGKLSWVLADRLHISRAEAGRRIAEAADLGPRRALSGAPLAPVLPATAAAQRDGAIGADHVAVIRRFFHQLPESVDVETCVHAEQHLAAKAGEFGPEQFAKLARRLMDCLHPDGSYTDEDRARVRGLVLGTQQADGMSRLSGWLTPEARASWEAVLAKLAAPGMCNPDDDTPAVDGAPSEEAVRRDTRSAAQRHHDGLNAALRAMLASGQLGQHNGLPASIVVTTTLADLERTTGTGLTGGGTLLPMSDVIRLARHAHHYLAIFDKGKPLALYHTKRLASPGQRIVLYAKDRGCTAPGCDVAGYYCEVHHVQEWATTYRTDIDQLTLACGPHHRLLDKGWTTRKRANGDTEWIPPPHQDRGQPRTNTFHHPEDLLREHDGEGDNAAGAA
>NZ_AP022590.1|WP_083097730.1|1788537_1789020_+|GreA/GreB-family-elongation-factor
MTSTPPVWISPHGYERLQRELARLRMLHSSANVDGQPDDNAIAVQFAWQARIQRIHDLLVNAVVGEDPPDDGIAEPGMVLTVRYDDTGDTETFLLGVRGAEYSDIEVYSNESPLGAAIAGARPGERRTYTLPSGATLDVTLLEAVPYGVHKAGLKSWPII
>NZ_AP022590.1|WP_083097731.1|1787926_1788541_+|GreA/GreB-family-elongation-factor
MTSTKSIWMTRQQYTRLRNKLNALRSGLIVEVPDDMMDFDANRSARQRRIREIQNLLAKAVVGEAGEDPAGDSIAEPGMVLTIRYDVTGETETFLLGRRGSEGAKIKVYSMASPLGRAIAGARPGDQRIYSIPGETGRLVTLVEAVPYEMHLRQGLVTGSPPRRNVNSGPSTQLTQHISETNRANHVRVARAETLSTTYGEQRI
>NZ_AP022590.1|WP_142275728.1|1796808_1797201_+|hypothetical-protein
MTEQPDRAAYNTTGVLETRCPDCGAAPYAWCVDGCGVRRIPCVGRLAAAVRALRGGSRDHPDLKSAIDDWRERRARGDVIEPGPPKPAADVAALACTATTVTHLTADGPFTEHVTVARAIMPKTQEGEQK
>NZ_AP022590.1|WP_083098722.1|1797197_1797782_+|hypothetical-protein
MNDETTTTEETELSPEALDIAVKATAGAEFTDSFRPPTPGAAVADEQPVEPSDTEEPSEVDTLKWLLAERDYRLDNPDENTEAARHRHARREAEAQTQAVTARLEAMQRAAIDAQVTAMGLKPAVLWAAGANLADLLGEDGTPDTAKVEAAAEAAKETLGVVAYKPVPARLQSGAMATPPKRDAWVDAFAPKSD
>NZ_AP022590.1|WP_083098724.1|1797928_1798780_+|phage-major-capsid-protein
MAFTATTPNSAQAWRPDVYEFAASDIIPDALILQCTTQGADVEGDAPAVRVAYVDDDEAQLSDEADEIPEAQPDLAERIIYTSKVTQLVRLSNEQFLQPSTAETIAQSVARAVTRRGDLFFTTQPAPVAPAVAPVAGLFNVPGLIDGGHVADDLDVLIDLIATLQHNLATPSLLLLDPTGWAAFRKLKTGTDRNLSLLGAGTSDAQAMLLSLPVIVNNAVPTGEGAVIDRNAIMSAVGTLKVATSDDRYFETDSVAVRATWRLGHTVVRPERIGTFTIGEGGS
>NZ_AP022590.1|WP_083098725.1|1798928_1799213_+|HNH-endonuclease
MSNTSTRLRRACFRRDDYTCVQCGYEGEPRSGELHVDHIINRAEGGTDDLDNLQTLCTRCHQPKSQAEAARGRQRHSGKRRPPLHPADAMSDLL
>NZ_AP022590.1|WP_142275729.1|1799346_1799715_+|hypothetical-protein
MTTSAAGRRLRAALSDALKRESEKAGLPLVFDAREQAHVDAAVRAADHVAKLQRLLNEEMRGERRVSVAAKLMAEIRLQDQVVADHVGKIGLPELAPTKSAQQQAAATARWGVNRPPKRVRS
>NZ_AP022590.1|WP_142275730.1|1799718_1800027_+|hypothetical-protein
MPIVDGGAVRPRRGVYAAVAEAIDEEFRKLAVLGREPEAVWPRWRAMMAYGATVEVPAFLVPREMRPRLEAGRPMLVARVSADDEISFRVETIAEATERLGL
>NZ_AP022590.1|WP_083098765.1|1800074_1800920_+|hypothetical-protein
MAAAMFKHELRQRGLGDVVRVSSAGTCITCADHGPADERAFWVLHRHGYRVPLGHRTQLLNADRLNADLVVAFGAEHVDLLRKWGVDDDRIRCLHAKNPHTLRQFEDAYGRIEAAMPALLAWVEQRRPVWWRWWKLTPDGVLASPIGGYRWETADYKAFCPHPIKGSCSCGVYAFTSAADCHAHIDATGRFAPDLLAPSECAGVVLGRVQLSADAYLAKAGLSVTRRGVPRRGDPVRSASPEWLASGARIMRLRSTGDQALDDRLAQRYGVPVFGDRDRRH
>NZ_AP022590.1|WP_083098731.1|1800924_1801386_+|hypothetical-protein
MKIADSRSAARYPDWETDPVTGYKDAVEPAEPGEIHAWLYTPDDVGPARWILNQRGTALLQDGHVEAACGLSLRVIYRMSFDMTQDNACPRCVRIARLWQTSRAEYYELIRERHERWAERDRRRYKALDANDLARQDSYGTDPIEDDDSGEPL
>NZ_AP022590.1|WP_142275731.1|1801389_1801575_-|hypothetical-protein
MSPEQRRELERLAAEHGDELTEQVVVDAARSPDSPLHSLFEWDDAKAARKYREVWANEQRN
>NZ_AP022590.1|WP_142275732.1|1801920_1802250_-|hypothetical-protein
MSMTTTPSPRPTVPLPDGATSDADDWAFWDNECRCFRGPERVVLNGAAEVIAEVRTVGVQLGDGRVDNGEDAPTIDVCLRGSELSPDEAQDLALALLNAAAEARGWVRG

Crispr_ID: NZ_AP022590_9

• CRISPR_ID: NZ_AP022590_9
• CRISPR_location: 2122122-2122576
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 8 spacers

Consensus repeat of NZ_AP022590_9

Consensus_repeat	Method
GCNTCGGCGGCCAGCGCTTNGGCNNC	CRT

spacers of NZ_AP022590_9

>9.1|2122148|34|NZ_AP022590|CRT
GGCGGCTTCGGCGCGCGCCCGCTCTAACACCTGC
>9.2|2122208|22|NZ_AP022590|CRT
GGCGGCCTCTGCCCGCGCCCGT
>9.3|2122256|22|NZ_AP022590|CRT
AGCGGCCTTCGCCCGCCTTCGC
>9.4|2122304|22|NZ_AP022590|CRT
GGCGGCTTTGGCCTGCTTTTGG
>9.5|2122352|22|NZ_AP022590|CRT
GGCGGCTTTGGCCCGCTTTCGC
>9.6|2122400|34|NZ_AP022590|CRT
CGCGGCGTCCGCGTGCGCCTTCTCCCGCGCCCGC
>9.7|2122460|43|NZ_AP022590|CRT
GGCGGCCTCTGCCTGCGCCCGAGCCTCGGCGGCCACGGCTTCG
>9.8|2122529|22|NZ_AP022590|CRT
GGCGGCTTCTTCCTGCGCCCGA

CRISPR arrays and Neighbor proteins around NZ_AP022590_9

CRISPR arrays

The CRISPR arrays of NZ_AP022590_9

>merge|NZ_AP022590|9|2122122-2122576|CRT
GCCTCGATGGCCTGGGCTTCGGCTTCGGCGGCTTCGGCGCGCGCCCGCTCTAACACCTGCGCCTCGGCGGCCAGCGCTTGGATTTCGGCGGCCTCTGCCCGCGCCCGTGCTTCAGCGGCCAGCGCTTCGGGCTCAGCGGCCTTCGCCCGCCTTCGCGCCTCGGCGGCCAGCGCGTGCGCTTCGGCGGCTTTGGCCTGCTTTTGGGCTTCGGCGGCCAGGGCTTGGGCTTCGGCGGCTTTGGCCCGCTTTCGCGCCTCGGCGGCCTGCGCTTCGGCGGCCGCGGCGTCCGCGTGCGCCTTCTCCCGCGCCCGCGCCTCGGCGGCCAGCGCTTCGGCGGCGGCGGCCTCTGCCTGCGCCCGAGCCTCGGCGGCCACGGCTTCGGGTTCGGCGGCCAGCGCTTCGGCGGCGGCGGCTTCTTCCTGCGCCCGAGCCTCGGCGGCGAGCGCTTCGGCTTC

>NZ_AP022590|9|1|2122122-2122576|CRT
GCCTCGATGGCCTGGGCTTCGGCTTC	GGCGGCTTCGGCGCGCGCCCGCTCTAACACCTGC
GCCTCGGCGGCCAGCGCTTGGATTTC	GGCGGCCTCTGCCCGCGCCCGT
GCTTCAGCGGCCAGCGCTTCGGGCTC	AGCGGCCTTCGCCCGCCTTCGC
GCCTCGGCGGCCAGCGCGTGCGCTTC	GGCGGCTTTGGCCTGCTTTTGG
GCTTCGGCGGCCAGGGCTTGGGCTTC	GGCGGCTTTGGCCCGCTTTCGC
GCCTCGGCGGCCTGCGCTTCGGCGGC	CGCGGCGTCCGCGTGCGCCTTCTCCCGCGCCCGC
GCCTCGGCGGCCAGCGCTTCGGCGGC	GGCGGCCTCTGCCTGCGCCCGAGCCTCGGCGGCCACGGCTTCG
GGTTCGGCGGCCAGCGCTTCGGCGGC	GGCGGCTTCTTCCTGCGCCCGA
GCCTCGGCGGCGAGCGCTTCGGCTTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022590.1|WP_083099613.1|2120498_2121500_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|285027
NZ_AP022590.1|WP_083099600.1|2130688_2131711_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380561
NZ_AP022590.1|WP_083100287.1|2116122_2116509_-|SEC-C-domain-containing-protein	unknown	unknown	gnl|CDD|225557
NZ_AP022590.1|WP_083099615.1|2119614_2120481_-|DUF58-domain-containing-protein	unknown	unknown	gnl|CDD|224635
NZ_AP022590.1|WP_083099620.1|2117260_2118187_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083100289.1|2113458_2114385_-|TPM-domain-containing-protein	unknown	unknown	gnl|CDD|377378
NZ_AP022590.1|WP_083100294.1|2114920_2116066_-|NADH-oxidase	unknown	unknown	gnl|CDD|176251
NZ_AP022590.1|WP_083099617.1|2119151_2119625_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083099621.1|2133483_2135004_+|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|239028
NZ_AP022590.1|WP_083099598.1|2131917_2132178_+|DUF1918-domain-containing-protein	unknown	unknown	gnl|CDD|378101
NZ_AP022590.1|WP_083099595.1|2135008_2135209_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083099618.1|2118183_2119161_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_169926985.1|2126866_2128018_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NZ_AP022590.1|WP_083099607.1|2124169_2126713_-|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl|CDD|223256
NZ_AP022590.1|WP_170298337.1|2116529_2117264_-|hypothetical-protein	unknown	unknown	gnl|CDD|227505
NZ_AP022590.1|WP_083099609.1|2123377_2124106_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|377550
NZ_AP022590.1|WP_083099601.1|2129241_2130126_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NZ_AP022590.1|WP_083099596.1|2132273_2133182_-|peptidase	unknown	unknown	gnl|CDD|259808
NZ_AP022590.1|WP_083099603.1|2128068_2129253_+|ATP-grasp-domain-containing-protein	unknown	unknown	gnl|CDD|235876
NZ_AP022590.1|WP_083100290.1|2113138_2113444_+|hypothetical-protein	unknown	unknown	gnl|CDD|227505

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP022590.1|WP_083099613.1|2120498_2121500_-|AAA-family-ATPase	gnl|CDD|285027	pfam07726, AAA_3, ATPase family associated with various cellular activities (AAA). This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.	4.56243e-77
NZ_AP022590.1|WP_083099600.1|2130688_2131711_-|ABC-transporter-substrate-binding-protein	gnl|CDD|380561	cd06338, PBP1_ABC_ligand_binding-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT); however, their ligand specificity has not been determined experimentally.	5.44228e-43
NZ_AP022590.1|WP_083100287.1|2116122_2116509_-|SEC-C-domain-containing-protein	gnl|CDD|225557	COG3012, COG3012, Uncharacterized protein conserved in bacteria [Function unknown].	1.26299e-43
NZ_AP022590.1|WP_083099615.1|2119614_2120481_-|DUF58-domain-containing-protein	gnl|CDD|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	2.9601e-19
NZ_AP022590.1|WP_083100289.1|2113458_2114385_-|TPM-domain-containing-protein	gnl|CDD|377378	pfam04536, TPM_phosphatase, TPM domain. This family was first named TPM domain after its founding proteins: TLP18.3, Psb32 and MOLO-1. In Arabidopsis, this domain is called the thylakoid acid phosphatase -TAP - domain and has a Rossmann-like fold. In plants, the family resides in the thylakoid lumen attached to the outer membrane of the chloroplast/plastid. It is active in the photosystem II.	1.63117e-21
NZ_AP022590.1|WP_083100294.1|2114920_2116066_-|NADH-oxidase	gnl|CDD|176251	cd08291, ETR_like_1, 2-enoyl thioester reductase (ETR) like proteins, child 1. 2-enoyl thioester reductase (ETR) like proteins. ETR catalyzes the NADPH-dependent conversion of trans-2-enoyl acyl carrier protein/coenzyme A (ACP/CoA) to acyl-(ACP/CoA) in fatty acid synthesis. 2-enoyl thioester reductase activity has been linked in Candida tropicalis as essential in maintaining mitiochondrial respiratory function. This ETR family is a part of the medium chain dehydrogenase/reductase family, but lack the zinc coordination sites characteristic of the 2-enoyl thioester reductase (ETR) like proteins. ETR catalyzes the NADPH-dependent dependent conversion of trans-2-enoyl acyl carrier protein/coenzyme A (ACP/CoA) to acyl-(ACP/CoA) in fatty acid synthesis. 2-enoyl thioester reductase activity has been linked in Candida tropicalis as essential in maintaining mitiochondrial respiratory function. This ETR family is a part of the medium chain dehydrogenase/reductase family, but lack the zinc coordination sites characteristic of the alcohol dehydrogenases in this family. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. Candida tropicalis enoyl thioester reductase (Etr1p) catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis. Etr1p forms homodimers, with each subunit containing a nucleotide-binding Rossmann fold domain and a catalytic domain.	1.87888e-140
NZ_AP022590.1|WP_083100290.1|2113138_2113444_+|hypothetical-protein	gnl|CDD|227505	COG5178, PRP8, U5 snRNP spliceosome subunit [RNA processing and modification].	0.00024381
NZ_AP022590.1|WP_083099621.1|2133483_2135004_+|molybdopterin-dependent-oxidoreductase	gnl|CDD|239028	cd02110, SO_family_Moco_dimer, Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). .	2.76043e-63
NZ_AP022590.1|WP_083099598.1|2131917_2132178_+|DUF1918-domain-containing-protein	gnl|CDD|378101	pfam08940, DUF1918, Domain of unknown function (DUF1918). This domain, found in various hypothetical bacterial proteins, has no known function.	2.87548e-27
NZ_AP022590.1|WP_169926985.1|2126866_2128018_+|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.78168e-20
NZ_AP022590.1|WP_083099607.1|2124169_2126713_-|excinuclease-ABC-subunit-UvrA	gnl|CDD|223256	COG0178, UvrA, Excinuclease ATPase subunit [DNA replication, recombination, and repair].	0
NZ_AP022590.1|WP_170298337.1|2116529_2117264_-|hypothetical-protein	gnl|CDD|227505	COG5178, PRP8, U5 snRNP spliceosome subunit [RNA processing and modification].	1.90388e-08
NZ_AP022590.1|WP_083099609.1|2123377_2124106_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|377550	pfam05711, TylF, Macrocin-O-methyltransferase (TylF). This family consists of bacterial macrocin O-methyltransferase (TylF) proteins. TylF is responsible for the methylation of macrocin to produce tylosin. Tylosin is a macrolide antibiotic used in veterinary medicine to treat infections caused by Gram-positive bacteria and as an animal growth promoter in the swine industry. It is produced by several Streptomyces species. As with other macrolides, the antibiotic activity of tylosin is due to the inhibition of protein biosynthesis by a mechanism that involves the binding of tylosin to the ribosome, preventing the formation of the mRNA-aminoacyl-tRNA-ribosome complex. The structure of one representative sequence from this family, NovP, shows it to be an S-adenosyl-l-methionine-dependent O-methyltransferase that catalyzes the penultimate step in the biosynthesis of the aminocoumarin antibiotic novobiocin. Specifically, it methylates at 4-OH of the noviose moiety, and the resultant methoxy group is important for the potency of the mature antibiotic. It is likely that the key structural features of NovP are common to the rest of the family and include: a helical 'lid' region that gates access to the co-substrate binding pocket and an active centre that contains a 3-Asp putative metal binding site. A further conserved Asp probably acts as the general base that initiates the reaction by de-protonating the 4-OH group of the noviose unit.	1.42685e-07
NZ_AP022590.1|WP_083099601.1|2129241_2130126_-|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	6.61335e-29
NZ_AP022590.1|WP_083099596.1|2132273_2133182_-|peptidase	gnl|CDD|259808	cd08826, SPFH_eoslipins_u1, Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model summarizes a subgroup of the stomatin-like protein family (SLPs or slipins) that is found in bacteria and archaebacteria. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Bacterial and archaebacterial SLPs remain uncharacterized. This subgroup contains PH1511 from the hyperthermophilic archaeon Pyrococcus horikoshi.	4.93436e-92
NZ_AP022590.1|WP_083099603.1|2128068_2129253_+|ATP-grasp-domain-containing-protein	gnl|CDD|235876	PRK06849, PRK06849, hypothetical protein; Provisional.	2.41319e-84

Protein sequences

>NZ_AP022590.1|WP_083099613.1|2120498_2121500_-|AAA-family-ATPase
MITTQTQPDQRELDSVRGIVDAISGAFTAKIVGQRDLRESLLIGLLAGGHILLESVPGLAKTTAAKVLAESIHGRFQRIQCTPDLLPSDIIGTQIYDSATNSFVTQLGPVHANIVLLDEINRSSAKTQSAMLEAMEERQTTIAGQVHPLEDPFMVVATQNPVDQEGTYPLSEAQTDRFLLKEIVRYPSPQEEVEVMSRIDAGIYDPRRPTAPVVSLDDVLRVQQVVRHVHMDRALMLYASQLVDVTRHPERALPKQIARLVEYGASPRATIAFCKAARAQAVLSGRAHVLPEDIAKLAHRVLRHRLILGFEAASADITAEVVVDAALRAVRVP
>NZ_AP022590.1|WP_083099615.1|2119614_2120481_-|DUF58-domain-containing-protein
MGKHLNRAKAHFGTDTRGLLEGGRYALLHTRSMEFDDLRPYVPGDDVRDIDWKASARSGAVLIKRFVSEKHHKILLVADAGRNMSALAPSGECKRDVAAHIMGAVGLIGLRRSDQIGMVYGDRRGCVNIPQRRGESHIEGLLHRWYQHTTANPGRSDVTAQLDYVATHYRHTMLIIVVSDEPEVDDRLSAVLARLGGRHDIMWAMVSDMPAVGPDNTDGYDVATGRFVFNGADLGPRVVTAYRRAERARRDRLDAFLTGHAIPHATIPGSNGIRRELVRLTEVAARAG
>NZ_AP022590.1|WP_083099617.1|2119151_2119625_-|hypothetical-protein
MPDDLLRYLFGPQPYSSWWLWLAVLLMLAVSGWYAAVFVWTLPSHQLRRIPAVRRVHAWLIRNRFARGVQGIADEHAAGRMSAPAACGAISRTVRSFLHQATGTRAQYLHVGAMADANLSAAEPLLTRLGNAQFNAEARVDVADVSAQVQELIRTWT
>NZ_AP022590.1|WP_083099618.1|2118183_2119161_-|hypothetical-protein
MDLKWWPVAATGSACFVAVVALAALLPMSAARRRLRPLANVARLTRLPEYAKVARLRSLSTVVTLVVLTVMFGAATWAAARPTVAGNDFDAVHPEDIMLCVGQPVTDAVTAELLDYFARQTATSPQAQRIGLTSVNRRLVPLTRDHQYAAARFADYVGAPNAQAASFTPPVPYTDYATSVNDVLALCLSGFSATEQRDTHRRSVIYLGPSELRAAGESRPSLFTDEAARELAGRAGAQINVIDTAPSSTSGALVAFTEHSGGRYVRPGTKSVTAALNEIRTHTPPARLANGTVVTADFRDAPMAPLVIALLAAAVLSVALLVLRR
>NZ_AP022590.1|WP_083099620.1|2117260_2118187_-|hypothetical-protein
MTFQPVLPWPILAVVTGALTLARLVALRQVLLSAGNRRVRTVLRWSGVTLAVLLLIAAITRPAIHDDESRRSATSAAGANLNVFLIVDRSADSGIQDYGTGEARIAGMRDDIAELIKQYPAARYALVNFDAKASLDWPLSQDVWSLRPTIAVLRSGASGSSDVNAAAADNVLRYQLVQAAQQYPGSRNVVLYFGSGAPGSHAPQGDFDLTQGSVAGGAVLGYGSSAAINEAELRQIAGQLNVQYLHRDAGQPLRPNLPDTPHGSGVGAARIELYWLPALLAAGLLLAEIYLSVREFRRGRIARRDLAP
>NZ_AP022590.1|WP_170298337.1|2116529_2117264_-|hypothetical-protein
MTIRPARLRLRRRLLLYSAPLTILALLVAIKLISVVAAGDSAVSAFSSGDGKAVQADAAILGVANVVEPAKAQFAAGVAAVLDGRLGDADTHFATALARTDADHSCPVRVNLELVRETQGDRAAAQGDRAGADERYASALSIVDAAPHGCFAGNNDPDSQRRAIRQEAANRLAAKRTAPPPAEPPPPPPPPPPPPAAPPPPPPPFATVTPDGREIPPRRLDPANGDPIDKLQQLLQDAAGVTTP
>NZ_AP022590.1|WP_083100287.1|2116122_2116509_-|SEC-C-domain-containing-protein
MNEPCPCGSGADYRACCGPLHLGESQARSAEELMRSRYSAFAYGDADYLFRTWHPRTRPADVTVDPDIIWTGLQVFDAWAGGPDDDSGEVEFTARFESAGHAGSMHERSRFERRAGRWLYLDAVTEDS
>NZ_AP022590.1|WP_083100294.1|2114920_2116066_-|NADH-oxidase
MTADLPDTALELRSLVRSDGTLELSLHDVAVPALGPNEVLVRVEASPINPSDLGLLIASADMSKAAVAGTPERPVVTAPVGEAGLRALSARLDESLPVGNEGAGTVVAAGSHEAAQALVGKTVAIAGGAMYSQYRAVDASACLVLPDGATARDGASSFVNPMTALGMTETMRREGHSGLVHTAAASNLGQMLVKLCQKDDIPLVNIVRKPEQAEMLRSLGASYVLNSTAPSFASDLAEALKATSATLAFDATGGGTLASQILNGMEQAANATATEYSRYGSATHKQVYIYGSLDTSPTVLNRNFGMAWGVGGWLLTYFLQSAGAETVGRLRARVAAGLTTTFASRYTQEVSLAGMLNPDAFNAYAKRATGEKFLVTPHAMP
>NZ_AP022590.1|WP_083100289.1|2113458_2114385_-|TPM-domain-containing-protein
MRVVRLFGVVVSILVAGLLWAAPAGAQPPSKLTDHITDSTGVLTDSGRAAVSAAIDRLYRDRHIQLWVVYVDNFNRFKPDNWADRTRSASGMGDHDVLLAVATNTKLYAFSVPPQVQGLTPAKLNSLRTNQIEPVLGAKDWSGAAVAAADGLDKSTSAPQPASSSKLAWLPIAIGVIVIVIVVVLALLFLLFRARRRRRAAASGGSIAIDGHDHSVQQALSTAEARLRQISDYAVRYRSNLGSEAQARLDEAKRHLAAAHGAETTSDTDAIAYANRASTLAAEAQTLANADVLAAHRTPRRRGNTSSR
>NZ_AP022590.1|WP_083100290.1|2113138_2113444_+|hypothetical-protein
MKVRVRSWTAGGIAVLTLAAIPETYAVVQPAGMANADVCASVGRRVSVSGCTNVADTINANVPPPDAYAPLPQDFPPPPPPPPPVNVCVGAGRRVHVSGCF
>NZ_AP022590.1|WP_083099609.1|2123377_2124106_+|class-I-SAM-dependent-methyltransferase
MTHSTGFNWAQLVKMPIVSDEWHKGHQILNFYPMDKDYRDSPAAREMVSKYFNNAKALNTDAALLKFGSDHVTLRGAFLEMGVCTGRTINFVAALNPEQHIWGFDSFDGLPEQWGRTDITVAKGTFRVNAEGWTPPVLHNVTLVKGMFHETLPQFKKQVLKSAPIAFLHVDCDIYASTKEIFKQLVDNIVSGTIIVFDEFYNYPGAEEHEFRAFQEFLDSTGKKPVYLAYNQYFEQAVVQIA
>NZ_AP022590.1|WP_083099607.1|2124169_2126713_-|excinuclease-ABC-subunit-UvrA
MTQMSYRSTDEIDPCVRVYGARVHNLRGVDVVAPRDALVAFTGISGSGKSSLAFGTIYAEAQRRYFESVAPYARRLLLPTGAPKVDDITGLPPAVALQQRRGSATSRSTVGTVTTLSNLLRMLFSRAGTYPRGATERLDSDAFSPNTAVGACPECHGLGRIHRVTEETLVPDPSLTIREGAVAAWPGAWQGQNLRDILVTLGYDIDKPWRKLPKRQRNWILFTDEQPTVEIDPSQHPVQADYYYNGTFSSAERHVRHTLANSHSAMMRRRVLQFVDSVECPVCDGSGLRPEALKVTFAGRTIADYTAMPLADLAEALRPTASRTDAAAAYESTQSGELTEVATMIAADLVARLQVLIDLGLGYLTLSRRTPTVSPGELQRLRLATQLRAGLFGVLYVLDEPSAGLHPADAEPLLEVLDRLRRAGNSLFVVEHDMDVVCRADWVVDVGPGAGELGGGVLYSGPVPGLADIEGSVTRRYLFDGAGSPPRQPRTQSGWLRLRGVCFHNLRDLDVDLPLGVYTAVTGVSGSGKSTLVVKVLGDVVRSHLGIGRAAEPVESDDDEADSGIADLDRDASVGVTAEGGKEINRLVSVDQRPIGRTPRSTLATYTGLFDAVRREFAATPKARRRGWTAGRFSFNVAEGRCSTCQGEGFVSVELLFLPGTYATCPACQGARYSDETLEVRYRDRTIADVLAMTVDEASEFFADVASAARSLTTLREVGLGYLRLGQPATELSGGEAQRIKLAAELQRPRRGHTLYVLDEPTTGLHPADVDLLDRQLHRLVDAGNTVVVAEHDMRMVAGADWVIDLGPGAGSDGGRVVAAGPPKKVARAKHSRTAPYLAKRLALADG
>NZ_AP022590.1|WP_169926985.1|2126866_2128018_+|alpha/beta-hydrolase
MTETSPSRIRLSHHVVVLDDGRRIGLSVGGRGVPLLFMHGLLLSRRAYLRMLSRIAGMGFLVVAVDAAGHGDTGRLPSDAYGFTDRADSVLRTLDALGIGQALFVGHSMGGRMTIQLAARAPERVLAAVLFDPAAGARFDTTIPELVKSPTKALGAAYTAVRDTLGDPTQLTPGEQLGYFRVLAAVAVPNLRYPLGAVRTIKAIIESGDYTPMLHTMRDEGMPTMVVHAEKDMIVPFPHARDIANESDATLYKVPDAYHSWMIANPRQGADAFRQLLDGELGEVLRNAADTMGIADVDDHEAWERELLDPDALVLEFIHGRDRVEIGAEELDHVDLERVRRTERSQERMSWARRTYRRWAAKHLHQARSVIRQNTRIEPEHRK
>NZ_AP022590.1|WP_083099603.1|2128068_2129253_+|ATP-grasp-domain-containing-protein
MSGFGRKTVLITFGRSYLSLHLARLMGAAGHDVLITDSVRFPVSRFSSAVRGTFRAPRPRYEPVEWTQALAHIVREEGVDMVVTVHEGTEILANTIKRYPDLFPDRHKLFLSSFDLEARLENKYEFQAALKTLGMPTLDFALVRSQEELEALDFDRPFALKRVYSRGSQDVHKVRPGELPRGLSFEEGNPWIAQEWADGTNYCSYSVCHDGQVKAHGLYPVRYAIDGTSCLFFESVQHEGIAEWTRECVKAFNFTGQMGLDFIEVPGRGLFTVECNPRATSGILLFDPETRVDRAFFGVNDEVITPRPGVSKMLGPGMLMYGWRKSSLEGNTFRGFLRDYRRTDDAVFTRSDLGPTLALPLVAATIFTEAARYQVNIPDAFMHDHDWDGGDLPL
>NZ_AP022590.1|WP_083099601.1|2129241_2130126_-|alpha/beta-hydrolase
MTDATGATPDDGFEFVIAEPGVELSVQRSGEGPTVLLVGGLGMPSITWNICGLPQSLVDAGFQVIAYNARGISPSSAPAAPYSVADLAADAAAILDHFKVDLPTVVGYSMGCYTSQALLRSRPDLVRALVLFAGLQPSPVGEMVGEMELRLIERYGELPREVLVFEQLLTTLHLPMLQDPATVRGWQQALSAGYESGWAGQEGFKGQLTASQQWITSGEPTPEHLGAIQVPTLVLAFEHDLFFPPALCEATARLIPNAEFVRIDGAGHGGIFTAPGDSVARITNFCRAQRDSQR
>NZ_AP022590.1|WP_083099600.1|2130688_2131711_-|ABC-transporter-substrate-binding-protein
MRVAARAVLVTPLSGPLARFGIAGASAVALWADSSGVSLEVIDAYPSAASAIRAAEASRPNVVFGPYGSGPALAAAAASTGVVWNHGGATARLARPAYPRVVNVESPAYRYLAAVLETLVADGLGEGSEVVIVHVDTGFGREVAEEAAVVARRLGLLRRSVTFRPGRARDMLAQVPAGDVLLSAGSFDDDVSIAQWASEHRWRAVGLVAAGVDELRHAIGDRVEGLYGPCQWFDDGTDDPADGPNSEWFSHCYRDANGIEPPYPAAAAFAAGVIWQRCVKEADTIESLPVMAASQQLDTTTLFGRFRVDPVTGVQTGHRIRVVQWRDGQRVLVDRPPHRQ
>NZ_AP022590.1|WP_083099598.1|2131917_2132178_+|DUF1918-domain-containing-protein
MKANVGDYLVVKGTTTERHDQHAEIIEVRSQDGSPPYVVRWLVTGHEATVYPGSDAVVVTAAEHTEAARRTAARARHAATTRTAVP
>NZ_AP022590.1|WP_083099596.1|2132273_2133182_-|peptidase
MIILYALAAAFGLGVLWLGTNVRVVKQFERGVVFRFGRAQTGVRGPGLTMLIPIADRLKKVNMQIITMPVPAQDGITRDNVTVRVDAVIYFKVADPVRVVVDVQDYVSAIGQVAQTSLRSIIGKSDLDDLLCNREGLNQGLELMIDSPAVGWGIHIDRVEIKDVVLPDSMKRSIARQAEAERERRARVITADGELQASEKLAQAAETMAVHPAALQLRLLETVVEVAAEKNSTLVLPFPVELLRFLERATPQASGSRDDEAAMPSTGAAASKTEMSKLDEPQIPEDASGLEVDTRIAGRYSD
>NZ_AP022590.1|WP_083099621.1|2133483_2135004_+|molybdopterin-dependent-oxidoreductase
MIAGVAAAAVALGVAQLVGIPFGARADARAAIGSVAVDLTPGPIKEWAIQSLGSLDKLFVAVVVLVVIATIAAIAGTLETQRRPLGSAMVGGAGVLGCIAVLSRQGATALDTIPTVAGAACGVATLRVLTRRFWPALGDPGDRADHDEPDAGRRRLIMLGLLGFGVVSGVAGAVITRLVHSVAADRNSFTLPRPRTSAPPIPADVQPNGVALPSFVTAGADFYRVDTALSVPQLSHGDWRLRIHGMVDHEATYSFDDLAHFDLVETVTTLTCVSNPVGGKLISTGIWTGYRVADLLAVARAHGDADMMLSTSIDGFTAGTPVQALTDGRDALLAVGLNGQPLPIEHGYPARLVVPGLYGYVSATKWVVEMELTRFDRAAAYWTRQGWAPRGPIKTESRIDVPKGGQKVPMGPVVFGGVAWAQNRGVRTVEVLIDDGVWQPAEQGASYSNETWRLWRFPWQAKSPGKHSITVRATDNTGGTQTADQVGTVPDGATGWHTVDFTVVKT
>NZ_AP022590.1|WP_083099595.1|2135008_2135209_-|hypothetical-protein
MRRAFVVTFAVGLIVAVFGLIWALQGFGVLGGSPMSNTTTWSIIGPITVLIGIVIALFSWRKLSSK

Crispr_ID: NZ_AP022590_10

• CRISPR_ID: NZ_AP022590_10
• CRISPR_location: 2214005-2214082
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: csa3

Consensus repeat of NZ_AP022590_10

Consensus_repeat	Method
AGGCCTGCATCGTCGCGGGGCTA	CRISPRCasFinder

spacers of NZ_AP022590_10

>10.1|2214028|32|NZ_AP022590|CRISPRCasFinder
TGCCCAACCGCCCCACTCCTCCTCAGGCCTAC

CRISPR arrays and Neighbor proteins around NZ_AP022590_10

CRISPR arrays

The CRISPR arrays of NZ_AP022590_10

>merge|NZ_AP022590|10|2214005-2214082|CRISPRCasFinder
AGGCCTGCATCGTCGCGGGGCTATGCCCAACCGCCCCACTCCTCCTCAGGCCTACAGGCCTGCATCGTCGCGGGGCTA

>NZ_AP022590|10|9|2214005-2214082|CRISPRCasFinder
AGGCCTGCATCGTCGCGGGGCTA	TGCCCAACCGCCCCACTCCTCCTCAGGCCTAC
AGGCCTGCATCGTCGCGGGGCTA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022590.1|WP_083095854.1|2218393_2219785_-|glycine--tRNA-ligase	unknown	unknown	gnl|CDD|235240
NZ_AP022590.1|WP_083095788.1|2207005_2208127_+|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274646
NZ_AP022590.1|WP_083095758.1|2221275_2222193_-|decaprenyl-diphosphate-synthase	unknown	unknown	gnl|CDD|173288
NZ_AP022590.1|WP_083095754.1|2222185_2222983_-|DNA-repair-protein-RecO	unknown	unknown	gnl|CDD|234622
NZ_AP022590.1|WP_083095793.1|2204984_2205668_+|serine-O-acetyltransferase	unknown	unknown	gnl|CDD|223975
NZ_AP022590.1|WP_083095772.1|2216125_2216347_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083095782.1|2210012_2211968_-|DNA-primase	unknown	unknown	gnl|CDD|235551
NZ_AP022590.1|WP_083095778.1|2212682_2213948_-|deoxyguanosinetriphosphate-triphosphohydrolase	unknown	unknown	gnl|CDD|235098
NZ_AP022590.1|WP_083095775.1|2214092_2216078_+|TPM-domain-containing-protein	unknown	unknown	gnl|CDD|377378
NZ_AP022590.1|WP_083095786.1|2208123_2209509_+|NtaA/DmoA-family-FMN-dependent-monooxygenase	unknown	unknown	gnl|CDD|274819
NZ_AP022590.1|WP_083095780.1|2211997_2212615_-|superoxide-dismutase-family-protein	unknown	unknown	gnl|CDD|224943
NZ_AP022590.1|WP_083095795.1|2204050_2204983_+|cysteine-synthase-A	unknown	unknown	gnl|CDD|273463
NZ_AP022590.1|WP_083095761.1|2220847_2221276_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083095767.1|2219975_2220398_+|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|238042
NZ_AP022590.1|WP_083095797.1|2202760_2204050_+|TQXA-domain-containing-protein	unknown	unknown	gnl|CDD|274864
NZ_AP022590.1|WP_083095769.1|2216922_2218137_-|PPE-family-protein	unknown	unknown	gnl|CDD|366325
NZ_AP022590.1|WP_083095784.1|2209750_2210029_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083095790.1|2205887_2207009_+|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274819
NZ_AP022590.1|WP_083095752.1|2223044_2224529_+|amidase	unknown	unknown	gnl|CDD|235686
NZ_AP022590.1|WP_083095764.1|2220447_2220843_+|transcriptional-repressor	unknown	unknown	gnl|CDD|223806

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_AP022590.1|WP_083095767.1|2219975_2220398_+|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	1.6e-18	61.9	0.4

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP022590.1|WP_083095854.1|2218393_2219785_-|glycine--tRNA-ligase	gnl|CDD|235240	PRK04173, PRK04173, glycyl-tRNA synthetase; Provisional.	0
NZ_AP022590.1|WP_083095788.1|2207005_2208127_+|LLM-class-flavin-dependent-oxidoreductase	gnl|CDD|274646	TIGR03558, oxido_grp_1, luciferase family oxidoreductase, group 1. The Pfam domain family pfam00296 is named for luciferase-like monooxygenases, but the family also contains several coenzyme F420-dependent enzymes. This protein family represents a well-resolved clade within family pfam00296 and shows no restriction to coenzyme F420-positive species, unlike some other clades within pfam00296. [Unknown function, Enzymes of unknown specificity].	1.82997e-96
NZ_AP022590.1|WP_083095758.1|2221275_2222193_-|decaprenyl-diphosphate-synthase	gnl|CDD|173288	PRK14827, PRK14827, undecaprenyl pyrophosphate synthase; Provisional.	0
NZ_AP022590.1|WP_083095754.1|2222185_2222983_-|DNA-repair-protein-RecO	gnl|CDD|234622	PRK00085, recO, DNA repair protein RecO; Reviewed.	3.46797e-87
NZ_AP022590.1|WP_083095793.1|2204984_2205668_+|serine-O-acetyltransferase	gnl|CDD|223975	COG1045, CysE, Serine acetyltransferase [Amino acid transport and metabolism].	3.82673e-90
NZ_AP022590.1|WP_083095782.1|2210012_2211968_-|DNA-primase	gnl|CDD|235551	PRK05667, dnaG, DNA primase; Validated.	0
NZ_AP022590.1|WP_083095778.1|2212682_2213948_-|deoxyguanosinetriphosphate-triphosphohydrolase	gnl|CDD|235098	PRK03007, PRK03007, deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional.	0
NZ_AP022590.1|WP_083095775.1|2214092_2216078_+|TPM-domain-containing-protein	gnl|CDD|377378	pfam04536, TPM_phosphatase, TPM domain. This family was first named TPM domain after its founding proteins: TLP18.3, Psb32 and MOLO-1. In Arabidopsis, this domain is called the thylakoid acid phosphatase -TAP - domain and has a Rossmann-like fold. In plants, the family resides in the thylakoid lumen attached to the outer membrane of the chloroplast/plastid. It is active in the photosystem II.	1.16116e-18
NZ_AP022590.1|WP_083095786.1|2208123_2209509_+|NtaA/DmoA-family-FMN-dependent-monooxygenase	gnl|CDD|274819	TIGR03860, FMN_nitrolo, FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family. This model represents a distinctive clade, in which all characterized members are FMN-binding, within the larger family of luciferase-like monooxygenases (LLM), among which there are both FMN- and F420-binding enzymes. A well-characterized member is nitrilotriacetate monooxygenase from Aminobacter aminovorans (Chelatobacter heintzii), where nitrilotriacetate is a chelating agent used in detergents. [Unknown function, Enzymes of unknown specificity].	2.81646e-158
NZ_AP022590.1|WP_083095780.1|2211997_2212615_-|superoxide-dismutase-family-protein	gnl|CDD|224943	COG2032, SodC, Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism].	1.5759e-24
NZ_AP022590.1|WP_083095795.1|2204050_2204983_+|cysteine-synthase-A	gnl|CDD|273463	TIGR01136, Cysteine_synthase, cysteine synthase. This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family].	1.03285e-173
NZ_AP022590.1|WP_083095767.1|2219975_2220398_+|winged-helix-turn-helix-transcriptional-regulator	gnl|CDD|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.36759e-17
NZ_AP022590.1|WP_083095797.1|2202760_2204050_+|TQXA-domain-containing-protein	gnl|CDD|274864	TIGR03934, fibronectin-binding_protein_I_partial, TQXA domain. This model describes a domain of about 40 residues with an invariant TQ dipeptide in an almost invariant TQxA[VI]W motif. This domain occurs in surface-expressed proteins of Gram-positive bacteria, many of which are anchored by LPXTG-containing sortase target domains. Numerous members of this family have domains pfam05738 (Cna protein B-type domain) and pfam08341 (fibronectin-binding protein signal sequence).	7.20932e-10
NZ_AP022590.1|WP_083095769.1|2216922_2218137_-|PPE-family-protein	gnl|CDD|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	3.36822e-53
NZ_AP022590.1|WP_083095790.1|2205887_2207009_+|LLM-class-flavin-dependent-oxidoreductase	gnl|CDD|274819	TIGR03860, FMN_nitrolo, FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family. This model represents a distinctive clade, in which all characterized members are FMN-binding, within the larger family of luciferase-like monooxygenases (LLM), among which there are both FMN- and F420-binding enzymes. A well-characterized member is nitrilotriacetate monooxygenase from Aminobacter aminovorans (Chelatobacter heintzii), where nitrilotriacetate is a chelating agent used in detergents. [Unknown function, Enzymes of unknown specificity].	6.59703e-72
NZ_AP022590.1|WP_083095752.1|2223044_2224529_+|amidase	gnl|CDD|235686	PRK06061, PRK06061, amidase; Provisional.	0
NZ_AP022590.1|WP_083095764.1|2220447_2220843_+|transcriptional-repressor	gnl|CDD|223806	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism].	2.50457e-46

Protein sequences

>NZ_AP022590.1|WP_083095778.1|2212682_2213948_-|deoxyguanosinetriphosphate-triphosphohydrolase
MTGNQHDPYDDFDRQRRVAEAPKTAGLPGTEGQHRTDFARDRARVLHSAALRRLADKTQVVGPREGDTPRTRLTHSLEVAQIGRGMAIGLGCDLDLVELAGLAHDIGHPPYGHNGERALDEVATDYGGFEGNAQNFRILTSLEPKVLDAQGNSAGLNLTRASLDAVTKYPWPRREGLRKFGFYDDDREPAAWVRAGAPEGRMCLEAQVMDWADDVAYSVHDVEDGVVSQRIDLRVLADDDEAAALAKLGETEFSRVRADDFMAAARRLSALPVVAAVGKYDATLAASVALKQLTSELVGRFASAAIATTRAAAGTGPLVRYRAELQVPDLVRAEVALLKILALQFIMSDPRHQETQAGQRERIHRVAHWLYAGAPRTLDPVFAAAFNTATGDGARWRVIVDQIASYTEGRLERIDARQGGP
>NZ_AP022590.1|WP_083095780.1|2211997_2212615_-|superoxide-dismutase-family-protein
MTKFSGPPFVASFLMALPVVAMTACSSPQHASTQPGTTPPVKSGAPTSSGETTPPAPGGGSLSAELKTPDGRSAATATFDFTGGYVTVTVKTAAPGILTPGIHGLHVHEIGKCEPNSVAPTGGAPGNFLSAGGHYQAPGHTGKPESGDLASLQVRQDGSAYLVTTTDSFNRDDLLAGNKTALMLHGAQDTENAMDRIACGVIGTG
>NZ_AP022590.1|WP_083095782.1|2210012_2211968_-|DNA-primase
MSSPAGSRADGDGRARGRGRIPDRDIAAIRDRVRIDEIVGDYVQLRRAGADSLKGLCPFHDEKSPSFHVRPNHGHFHCFGCGEGGDVYAFIQKIEHVSFVEAVELLADRIGHTIAYSGPATSVQRDRGSRSRLVAANAAAAAFYAAALESAEAAPARQYLTERNFDAEAARHFGCGFAPSGWDSLTKHLVRKGFEFKELEAAGLSRQGRRGPMDRFHRRLLWPIRSSAGEVIGFGARRLFDDDPMEAKYINTPETLLYKKSNVMFGIDLAKRDIARGHQAVVVEGYTDVMAMHLAGVTTAVASCGTAFGDEHLSMLRRLMMDDSFFRGELIYVFDGDAAGRAAALKAFGGEQNLAGQSFVAVAPDGMDPCDLRLKSGDGALRDLVARRTPLFEFAIRSALAEMDLDSAEGRVAALRRCVPMVSQIKDPTLRDEYARQLAGWVGWDDVAQVIDRVRSQSKTSNAQARGGAGVKAPRRGADPAPVAAQPGAGRPDPRDPTLWPQREALKAALQYPAFAGPVFDTLTVESFTHPGYAAIRVAIETAGGTSSGTTGAQWIEAVRDQAASPLTAGLASELGVEAIQVDEEKLPRYIGGVLARLQEVWMGRQIAEVKSKLQRMSPIDQGDEYHALFGDLVAMESYRRSLLEQASGDD
>NZ_AP022590.1|WP_083095784.1|2209750_2210029_+|hypothetical-protein
MIRYVVVLGLGYVLGSKAGRRRYEQLVGTYRALTSSPVAKSMIEGGRRKVANRISPDAGFVTLTEIDDQTAIMERDVEGSADDVLAPSNRRR
>NZ_AP022590.1|WP_083095786.1|2208123_2209509_+|NtaA/DmoA-family-FMN-dependent-monooxygenase
MTVREAVRRKRIHLGAHFPGVNNTTVWSDPSAGSQIAFQSFVHLAKTAERGLFDFLFLAEGLRLREHRGHIHDLDVVGRPDTFTVLAALAAVTDKLGLAGTINTTFNEPYEVARQFATLDHLSDGRSAWNMVTSSDAFTGANFRRGGFLAHADRYRRAEEFIAVARRFWDSWAPDAVIADVDAGIYADPARIGTVEHHGPQFDVRGVASLPAGPQGHPVLLQAGDSGDGRDFGARHADALFTLHGSLEAGQRYYADVKSRAAAHGRDPDQLKVLPGATFALGDTPAEAEDNARCIREQQVSGPAAIAFLEQVWGVDLSAYDPDGPLPDVDPVENPDITRGRVRHGDPKTVAETWRARAKAENLSIRELIIEVTSRQQFVGTPDQVATEIDRYVQSDACDGFILVPHLTPHGLDEFVEKVVPLLQERGSFRTEYRGTTLREHLGLLPAPVRAGNPAGIAIGQ
>NZ_AP022590.1|WP_083095788.1|2207005_2208127_+|LLM-class-flavin-dependent-oxidoreductase
MTVTPLSILDLAPISAGSDPATALRNTIDLAQHAERWGYKRYWLAEHHFVAVASSSPVTLIGQIAAATKRIHVGSAAVQVGHQTALAVVESFGILDALHPGRIDMGLGRSGQRRQEAATSAPAPAERQPTPWREMDGVVIPTPFDQTPLMKSERIRAQASVLAQPCAQPPDFADQLADIEAMLDGTYSVNGHELHAVPGEHAHLTPWIFGSTTGQSAEVAGARGLPFVASYHITPGTALDAITWYRNAFRPSARLSEPYVVVSADVVVAEDSTTARHLASGYGRWVYSIRSGHGAIPYPDPDFCEPLTEDQQALVADRTATQFVGNPDEVADRLELLRRVTSADELLITSVTHRHVDRLRSHELIAKRWGLTG
>NZ_AP022590.1|WP_083095790.1|2205887_2207009_+|LLM-class-flavin-dependent-oxidoreductase
MTELHLAVALDGYGWHPQAWRYAFAHNATGGGQLSGRYWAALAGTAERGLLDFLTIDDSLDAQPGRRAEISPRRLAGRADATLVAARVAPVTTHIGLILVATVTHTEPFHISKAVATLDHVSHGRAGWQVRVSPTAHEAALFGRRPAPAGDELFEEAADAVEVVRRLWDSWEDDAVIRDLETGRYIDRAKLHYIDFAGAHFSIKGPSITPRPPQGQPVVAALAHAPRVYEFAAANADLVFVTPRDEGSLRAILADVDQAQRAAGRAIQVYADLVVALAEDPSAPVAALSSDAHVFHGSTSDLVELLLAWQDAGVDGVRLRPAVNALDLPAIVDDLVPRLQRAGRFRTGYRDGETLRERLGLAPAPNRYATAPS
>NZ_AP022590.1|WP_083095793.1|2204984_2205668_+|serine-O-acetyltransferase
MLAAIRRDIRAARERDPAAPTTLQVIFAYPGVHAIWAHRINHWLWHRGARLIARITAEITRILTGVEIHPGAVLGPGLFIDHATGVVIGETAEVGEDVTIYHGVTLGGSGRDTGKRHPTIGDRVTIGAGAKVLGAIKIGDDSRIGANAVVVKEVPSSSVVVGVPGQVISRSLPGSPDDSMMPDLVGVSLQSLLTRVTKLEARADGARTNHVIRPPEAGVWHGEDFSI
>NZ_AP022590.1|WP_083095795.1|2204050_2204983_+|cysteine-synthase-A
MSIAENVTELIGNTPLVRLNRVTEGAVADVVAKLEFFNPGNSVKDRIGVAMIDAAEQAGLIKPDTIILEPTSGNTGIALALVAAARGYRCVLTMPETMSVERRMLLRALGAEIVLTPGSEGMPGAIAKAEELAKSDQRYFVPQQFENKANPAIHRATTAEEVWRDTDGKIDIFVAGVGTGGTITGVAQVIKERKPSAQFIAVEPAGSPVLSGGQKGPHPIQGLGAGFVPPVLAMDLVDEVIAVGNEESIALARRLASEEGLLVGISSGAAAVAALQVARRPENAGKLIVVVLPDFGERYLSTPLFADLAD
>NZ_AP022590.1|WP_083095797.1|2202760_2204050_+|TQXA-domain-containing-protein
MTILSEPGRALAPVTTRRRSVVRPARALNRLTRYRGGTYSHTVDRVVFTDGSWARTDLIRLNPNVHAYSLDFTGVAPRHPSRYRVDTWSALPHLRTSGHEARIGWILRHSFPMHSTAELSQQVREAGYPLGPANINEHEAIAATQAAIWFFTNRLTLDTRPLNVPVTVRRSAGPVFTFEFDGEPQLGGYSVWTDSPTAVNFKLQKSPNGVVWQDVSGSELTAGPGAGRHQRTLGQGSTLSSSSHGRGGRGYRYYRLAASSDTDTPRIGPVSFRLTGARYYRNADKVVHLYNYLLAQARKAVHETGEAALVDHRAGADGGLIGPFQVRIPLLFSANDGQEVVDTDGFTLGGPIEPGTDFYLRQPTGMSGITITAKTVGELHGRVLTGVALDEASHRFTPVALAIPTEMNIEFDISWQVDEAWSYVVGDKR
>NZ_AP022590.1|WP_083095775.1|2214092_2216078_+|TPM-domain-containing-protein
MRCTARLIAVIATILTVGCGGGFLLAPPANAQPPFRLADYITDHAGALSDSGRGAVNSALDKLYTDRHIRLWVVYVDNFSGQTATGWAQRTMSDSDLGTYDALLAVGTGGREYAFLVPSTIKGVNANQVDKLRHNKIEPALHNGDWSGAAVAAANGLDTSPGSTGRVALLAVLVGVLLALGVLLLVMRYRGRRRRAAALAAARRVDPTDAAALAGVSPQALDDLSRELVVDVDNALRTSANELDLAVTEFGEERTQPFTQAVTKAKAALSQAFTIRQQLDDQTPETPAQHRELLTQVIVSAARADRELESQTEAFEKLRDLVINAPTRLDSLTQQYVELTTRIAPAEQRLAALHNDFSAAALTSVSGNVTAAKERLAFADRNIGSARELAAQAVSGKQAGLVDAVRAAESALGQARALLDAVDNAATDIQHAIDRLPSAMTDIQNDIKRADDLLQKAPNPKTTHTGDLVAARDAAIGAVERARAGASDDPLGAFGQLTKADAGLNGLLATLAQEQAAVEQLNRALEQALFTAQSRVRAVSDYIDTRRGSIGPEARTRLAEAKRHLQAAEDKRSTLPTEAIAHAHAASTLAATAQSLANDDVQTAQRAYAGRSGGDMGAMLGGIIIGNVLSGGMRGGFGGWSPTSFGGSSSGGGFLGGGGRF
>NZ_AP022590.1|WP_083095772.1|2216125_2216347_-|hypothetical-protein
MLGGLSVPLRWGVVVPPDDYDHWAPKVEAGAEVPEETVDVPRPTAVADGVWSGWEGDTVPRSPGVIPHSPAAG
>NZ_AP022590.1|WP_083095769.1|2216922_2218137_-|PPE-family-protein
MIPSFVFFPPEINSALIFGGAGAGPLFEAASAWDGLAVELSTSASSFQTVISDLVGGAWMGPSSISMTVAAAPYLQWLVIAAAQAEVAALQARIAALAFEGAVVATVPLPAVLANRARLLVLIATNFLGINTAAIAQTELEYLEMWAQDVAAMLGYHAGAQSMAQALPEFSVPPPAPSGGGASAGLAGLADLVTAPLNFASQFFQGLSSLGTAFVTELQPLLSVFSPAVSLLSSTPVATLTTVAQAGMYPAAALMTPMVTLAHSPGPAAPAASAPLTAPTLVGVTSPPLNSSHSTGSALSDLQPLAGGGLGALGIATAGLGSARFIGSMSVPAAWEGSMPAYIATPAMSGVGSGAPAAAAAASGSGVPVAAMPVGEKNTEGEDRGTKAEVVRSRPKVVPRNRPG
>NZ_AP022590.1|WP_083095854.1|2218393_2219785_-|glycine--tRNA-ligase
MHRPVASVIDTVVNLAKRRGFVFPSGEIYGGTRSAWDYGPLGVEFKENIKRQWWRSVVSGRDDVVGLDSSIILPRQVWVASGHVEVFHDPLVESLITHKRYRADHLIEAYEAKHGHPPPNGLADIRDPETGEPGQWTEPREFNMMLKTYLGPIETEEGLHYLRPETAQGIFVNFANVVTTARKKPPFGIGQIGKSFRNEITPGNFIFRTREFEQMEMEFFVEPSTAKEWHQYWIDTRLQWYVELGIDPENLRLFEHPADKLSHYSDRTVDIEYKFGFAGNPWGELEGVANRTDFDLSTHAKHSGVDLSFYDQVTDTRYTPYVIEPAAGLTRSFMAFLIDAYVEDEAPNAKGKMEKRTVLRLDPRLAPVKAAVLPLSRHADLSPKARDLAAELRKFWNIDFDDAGAIGRRYRRQDEIGTPFCVTVDFDSLEDNAVTVRRRDDMSQERVAMNAVSDYLATRLKGC
>NZ_AP022590.1|WP_083095767.1|2219975_2220398_+|winged-helix-turn-helix-transcriptional-regulator
MTSPSSSPPAPAAANDPGVGAVAHGHDALAPGGHARAAAYPVPPPRDILDAAGELLRALAAPVRIAIVLQLRESHRCVHELVDALAVPQPLVSQHLKILKAAGVVTGERSGREVLYRLADHHLAHIVVDAVAHASEEPRQ
>NZ_AP022590.1|WP_083095764.1|2220447_2220843_+|transcriptional-repressor
MTGTSVRSTRQRAAISTLLETLDEFRSAQELHDELRRRGENIGLTTVYRTLQSMAAAGMIDTLRTDTGESVYRRCSEHHHHHLVCRSCGATIEVGDHEVEEWATAVAAKHGFSDVSHTIEIFGTCSDCGGR
>NZ_AP022590.1|WP_083095761.1|2220847_2221276_-|hypothetical-protein
MPSLQERLASILGDVLPLEEEADGAVTVRHGGTIASLRVVNIAEGLDLVSLTQILAWDLPLTKKISEQVTKQARDSNFGSVSLIEKVNDKAVQRNSGKGASKTADVMLRYNFPGGGLTDEALRTLILLVLDTGAEIRRALTA
>NZ_AP022590.1|WP_083095758.1|2221275_2222193_-|decaprenyl-diphosphate-synthase
MAKLWAGGSDQKAERATAAADFPQLPPAPDDYPVFPDKSTWPVVFPELPPSADGGPCRPPQHISKAAPPRIEADRLPNHVAIVMDGNGRWATQQGLTRTDGHKAGEAVVIDIVCGAIELGIKWLSLYAFSTENWKRSPEEVRFLMGFNRDVVRMRRVNLNAIGVKIRWVGSRPRLWRSVINELVIAEDMTKGNDVITVNYCVNYGGRAEIAEATKEIARLAAAGRLNPERITESTVGHHLQRPDIPDVDLFLRTSGEHRSSNFMLWQAAYAEYVFQDKLWPDYDRRDLWAACEEYASRNRRFGSA
>NZ_AP022590.1|WP_083095754.1|2222185_2222983_-|DNA-repair-protein-RecO
MRLYRDRAVVLRQHKLGEADRIVTLLTRDHGLVRAVAKGVRRTRSKFGARLEPFAHIDAQLHSGRNLDIVTQVVSIDAFATDIVNDYGRYTCGCAMLETAERLAGEERAPAPALHGLTVSALRAVADGRRSRDLLLDAYLLRAMGIAGWAPALTECARCATPGPHRAFHVGVGGSVCSHCRPAGSTTPPPGVLDLMSALHDGDWDFAEETPQSHRNYVSGLVAAHLQWHLERQLKTLPLVERTYHADRTIAEQRAALIRQDMDCG
>NZ_AP022590.1|WP_083095752.1|2223044_2224529_+|amidase
MIGASGSGPGSISGSRRRRLPTLTDLLYQLASRSVTSTTLVGRSLHAIHASQPTLNAFRVVLTESALADAAEADRRRAAGDTAPLLGIPIAVKDDVDVAGVPTAFGTEGSVAPAVQDAEVVRRLKAAGAVIVGKTNTCELGQWPFTSGPGFGHTRNPWSRRHTPGGSSGGSAAAVAAGLVTAAIGSDGAGSIRIPAAWTHLVGIKPQRGRISTWPLPEAFNGITVNGVLARTVADAALVLDAASGNVEGDRHQPPRITASDYVGKAPGPLNIALSTRFPYTGFRPKLHPEILAATRAVGKQLELLGHTVVPGNPDYGMRLSWDFLARSTSGLRDWEERLGDGVVLDPRTLSNLRVGAVLGQAILRTARRHEAADQRRVGSIFDIVDVVLAPTTAQPPPLARAFDRLGGFGTDRAMVAACPLTFPWNVLGWPSINVPAGFTSDGLPIGVQLMGPANSEGMLISLAAELEAVCGWASQQPQPWWDETAEPPGGING

Crispr_ID: NZ_AP022590_11

• CRISPR_ID: NZ_AP022590_11
• CRISPR_location: 4322698-4322790
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP022590_11

Consensus_repeat	Method
GCCGTCGCCGTCGGTATCGACGTA	CRISPRCasFinder

spacers of NZ_AP022590_11

>11.1|4322722|45|NZ_AP022590|CRISPRCasFinder
ACCGGTCACGCCGTTTTCGTCGGACCGCAGGACGCGGTCGGCGAG

CRISPR arrays and Neighbor proteins around NZ_AP022590_11

CRISPR arrays

The CRISPR arrays of NZ_AP022590_11

>merge|NZ_AP022590|11|4322698-4322790|CRISPRCasFinder
GCCGTCGCCGTCGGTATCGACGTAACCGGTCACGCCGTTTTCGTCGGACCGCAGGACGCGGTCGGCGAGGCCGTCGCCGTCGGTATCGACGAG

>NZ_AP022590|11|10|4322698-4322790|CRISPRCasFinder
GCCGTCGCCGTCGGTATCGACGTA	ACCGGTCACGCCGTTTTCGTCGGACCGCAGGACGCGGTCGGCGAG
GCCGTCGCCGTCGGTATCGACGAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022590.1|WP_083099563.1|4305527_4308383_+|RND-family-transporter	unknown	unknown	gnl|CDD|129913
NZ_AP022590.1|WP_083099557.1|4314080_4314947_-|DUF4226-domain-containing-protein	unknown	unknown	gnl|CDD|226462
NZ_AP022590.1|WP_083099541.1|4324738_4326268_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083099544.1|4323162_4324605_-|CCA-tRNA-nucleotidyltransferase	unknown	unknown	gnl|CDD|131739
NZ_AP022590.1|WP_083099571.1|4326390_4326627_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_142275789.1|4326662_4326938_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083099536.1|4327755_4330155_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083095089.1|4336888_4338112_+|peptidoglycan-binding-protein	unknown	unknown	gnl|CDD|223929
NZ_AP022590.1|WP_083099559.1|4312590_4314078_-|type-VII-secretion-protein-EccB	unknown	unknown	gnl|CDD|368288
NZ_AP022590.1|WP_083099561.1|4308363_4312587_-|type-VII-secretion-protein-EccCa	unknown	unknown	gnl|CDD|274858
NZ_AP022590.1|WP_158086115.1|4316263_4318408_-|DUF5631-domain-containing-protein	unknown	unknown	gnl|CDD|376071
NZ_AP022590.1|WP_083099574.1|4318397_4318847_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083099548.1|4320636_4322601_-|hypothetical-protein	unknown	unknown	gnl|CDD|283837
NZ_AP022590.1|WP_083099550.1|4320242_4320572_-|DUF2563-family-protein	unknown	unknown	gnl|CDD|287754
NZ_AP022590.1|WP_083095088.1|4336402_4336756_+|thioredoxin	unknown	unknown	gnl|CDD|200072
NZ_AP022590.1|WP_083099538.1|4327024_4327759_+|NUDIX-hydrolase	unknown	unknown	gnl|CDD|239645
NZ_AP022590.1|WP_163650979.1|4315218_4316115_-|hypothetical-protein	unknown	unknown	gnl|CDD|236090
NZ_AP022590.1|WP_163650869.1|4335395_4336406_+|thioredoxin-disulfide-reductase	unknown	unknown	gnl|CDD|273540
NZ_AP022590.1|WP_083099552.1|4319106_4319655_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083099529.1|4334538_4335309_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP022590.1|WP_083099563.1|4305527_4308383_+|RND-family-transporter	gnl|CDD|129913	TIGR00833, Putative_membrane_protein_ActII-3, Transport protein. The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate].	0
NZ_AP022590.1|WP_083099557.1|4314080_4314947_-|DUF4226-domain-containing-protein	gnl|CDD|226462	COG3953, COG3953, SLT domain proteins [General function prediction only].	4.79736e-23
NZ_AP022590.1|WP_083095088.1|4336402_4336756_+|thioredoxin	gnl|CDD|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	2.97711e-51
NZ_AP022590.1|WP_083099544.1|4323162_4324605_-|CCA-tRNA-nucleotidyltransferase	gnl|CDD|131739	TIGR02692, putative_tRNA_nucleotidyltransferase, tRNA adenylyltransferase. The enzyme tRNA adenylyltransferase, also called tRNA-nucleotidyltransferase and CCA-adding enzyme, can add or repair the required CCA triplet at the 3'-end of tRNA molecules. Genes encoding tRNA include the CCA tail in some but not all bacteria, and this enzyme may be required for viability. Members of this family represent a distinct clade within the larger family pfam01743 (tRNA nucleotidyltransferase/poly(A) polymerase family protein). The example from Streptomyces coelicolor was shown to act as a CCA-adding enzyme and not as a poly(A) polymerase. [Protein synthesis, tRNA and rRNA base modification].	0
NZ_AP022590.1|WP_083095089.1|4336888_4338112_+|peptidoglycan-binding-protein	gnl|CDD|223929	COG0860, AmiC, N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane].	4.29281e-54
NZ_AP022590.1|WP_083099559.1|4312590_4314078_-|type-VII-secretion-protein-EccB	gnl|CDD|368288	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B. EccB is a family of largely Gram-positive bacterial transmembrane componenets of the type VII secretion system characterized in Mycobacterium tuberculosis, systems ESX1-5. Translocation of virulent peptides through the membranes is thought to be mediated via a complex that includes EccB, EccC, EccD, EccE, and MycP. EccB, EccC, EccD, and EccE form a stable complex in the mycobacterial cell envelope.	7.03705e-173
NZ_AP022590.1|WP_083099561.1|4308363_4312587_-|type-VII-secretion-protein-EccCa	gnl|CDD|274858	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa. This model represents the N-terminal domain or EccCa subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	0
NZ_AP022590.1|WP_158086115.1|4316263_4318408_-|DUF5631-domain-containing-protein	gnl|CDD|376071	pfam18645, DUF5631, Family of unknown function (DUF5631). This is an alpha helical domain found at the C-terminal region of the hypothetical protein Rv3899c from Mycobacterium tuberculosis which is conserved across mycobacteria.	2.44733e-44
NZ_AP022590.1|WP_083099548.1|4320636_4322601_-|hypothetical-protein	gnl|CDD|283837	pfam06259, Abhydrolase_8, Alpha/beta hydrolase. Members of this family are predicted to have an alpha/beta hydrolase fold. They contain a predicted Ser-His-Asp catalytic triad, in which the serine is likely to act as a nucleophile.	2.5999e-23
NZ_AP022590.1|WP_083099538.1|4327024_4327759_+|NUDIX-hydrolase	gnl|CDD|239645	cd03673, Ap6A_hydrolase, Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most preferred substrate, hydrolyzes to produce two ATP molecules, which is a novel hydrolysis mode for Ap6A. These results indicate that Ap6A hydrolase is a diadenosine polyphosphate hydrolase. It requires the presence of a divalent cation, such as Mn2+, Mg2+, Zn2+, and Co2+, for activity. Members of the Nudix superfamily are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site.	1.49668e-48
NZ_AP022590.1|WP_163650979.1|4315218_4316115_-|hypothetical-protein	gnl|CDD|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0.000206092
NZ_AP022590.1|WP_163650869.1|4335395_4336406_+|thioredoxin-disulfide-reductase	gnl|CDD|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	2.23629e-158
NZ_AP022590.1|WP_083099550.1|4320242_4320572_-|DUF2563-family-protein	gnl|CDD|287754	pfam10817, DUF2563, Protein of unknown function (DUF2563). This family of proteins with unknown function appears to be restricted to Mycobacterium.	2.53756e-41

Protein sequences

>NZ_AP022590.1|WP_083099548.1|4320636_4322601_-|hypothetical-protein
MLLRHLSVPFLVAEAGGDPWSVNASLQAGRPAQISALAQAFRDAGVSTVEAGVAFEAARRRFDAAWNHQNGGRPFNDDAEVRRVTRSLGLQTSQLPRIAIDLENVAAALAEAQRTSAWYIGALQYDLEAIDNEMCEALADDDHCAVEDLRAEAVAETRAIAFLLRQIRDRYAASLAAGLGALRTDGADPAEIRGVDELSIPPPDSGPEAAKRWWDSLSADQQHLLIDQHPHELGNLNGILAEVRDTVNQAALKDDLRKVEDVARQRGLDPAALRDSALSDRDSEIFTTPGDYGLCATDITRYQNAVKTNDFLERAKGSDATIMLWAYDPLAFNGKGRAAIAIGNPDKSRNTAVVVPGTNSSVRGGWMSDGTDDAINLYEQSSKADPNQPTAVLAWMGYDAPEFGNPHWEQAVTDPSKLEEVGTPWRARQAGALLAADVNGLSATHDGPVHVTVLGHSYGSTTVADAFAHSGMRANDAVLTGCPGTDLARKAADFHLDGGRLYVGAASTDAISWIGDLGSGLPNGLNEALGGPVGPLAGLGSDPAHAGFGVVRFRAEVAGSHSVMPWFTDHSHYYDVGSEALHNMTEIVTGHGDDLAGEGMLASDRAAARIAIPLQVRTPLGTVSLPHVGIQLPVTVDPEWDRPTRSVTNGHGFR
>NZ_AP022590.1|WP_083099550.1|4320242_4320572_-|DUF2563-family-protein
MFVDTELLHSGGNQSHRAGGHAQEGADQLAGGTVASGMFGDFDAANAFHSAVAAAHGQHVKTLQGHSETLTGVGTKAHHAATGFTNMDSHNAAEMQALRPSSGSSTQNV
>NZ_AP022590.1|WP_083099552.1|4319106_4319655_-|hypothetical-protein
MAGDLPPAPGSGPRVSPPGSTQWAPVFPTQSHRRSRTWPSVALAGVATVVAIAALVVALTRPTATKPTTTSTPTYSAAEATTAQRQLCDTYKQVARAVQADTNGHDVALGRIALTNAAAMLDDASANPALGATYRDPAHALAAAYRQGTAMGNRDVATDAQFQAALDDINAKDAAMKKVCGS
>NZ_AP022590.1|WP_083099574.1|4318397_4318847_-|hypothetical-protein
MGNSSTHLRRLASRSSRSPLTLALARPTAPHTSVNSTSPTHATAEIATAQQRLCETYKVAARVVQVDTNGRDKAFARIALTNSAALHYSALNDPPLDEPHRSAAQTLATAYLTDTAKSSEGAPTEAEFQKAVADASAKDAAMKKVCGGG
>NZ_AP022590.1|WP_158086115.1|4316263_4318408_-|DUF5631-domain-containing-protein
MAVDLPPGTWTSALIGPWWPAPSTGLRAAAQHWSQECGEQQLYSQNLRVQWTAFAANNKGHTADDLITRFQQGEKLHLDLAEKYQTKASAFNSGADAIDYLRSRLSDIANTGNKEINKILASKKLPPEKLAEIQAVQARCNADAANASRDALDKMMAATQKILDADGIGGDARSWAAANGFNVGDASPPKPISQQDLNSAGGGVGGGGVRGDGGVPAPAGSPGHAPPATAVGGGIRGGGGVPPSRPSGGSAPVGGDGVRGGIPAASAPLSPAGVQMPGGGGTVSPGMPGVHGGGMPISPAGLGQGGQPGLAQAFTSGLATGQATGPGGQAFTAGPIQAMEAGGPQTPQATPAVTPTAPSAGAFIPASPPVDAPPPASPAPTATGGGTSVAPVMPSGSWSSPAPTVGGGSSIPSGSLPAYGSDLRPPVVAPPSVPSTPAGPVSGAPVASSPASSPSAGGPVVSPVERAAGSTAGQAGAGSSTMAGASAASAATGATAGAVSARTAEQRRLQRLVDAVARQEPRLSWAAGLRDDGVTTLLVTDLAGGWIPPHVRLPAHITLLEPTARRHDANVVDLLGAITVAAAHHANTYVAEPGPDEPALSGDRPARSAAPEVDELGPTLVDAVRRRDGLPRIAQAVAAPAVRKTGVLESETAMLRECAAEIQHSVLAAYPNHDPTVVGDWMLLAAIEALIDGHEYLANYHLAWFDAIGHRSRS
>NZ_AP022590.1|WP_163650979.1|4315218_4316115_-|hypothetical-protein
MSSDLPSTTVLINGVPVQVPGPGPGHPPDQSPAGGGGGGALTGAGNAGVPKDAADAAAADADRRAHAADAAAKFPANEATSQQDMQMIQQMLQSVTGAVGGAIGGVMGPLTQLPQQAMQAGQSALQPLMSAVQGAHGAGLASDAHLVDSVGSGGGSGLGAGSGGGGAGLGGGGTTPASSLGPPPVPTSSPPTTPAAAKAAMMPPTGGMPAMPGQSGMTGMPMMPPGAMGHGGEGGNKDKPVEKRVTAPGVPNGQPVKGRLTIPPSAPGNKSGEAKPTVVTNRPNRRIVIMPSEDEPKE
>NZ_AP022590.1|WP_083099557.1|4314080_4314947_-|DUF4226-domain-containing-protein
MTDPLKAQAVAALSRAHKLFGEPATGDGIGDAPAHTQARADATWHGTARLPGAAAARSGTAIRRLSRLSHTDRALEQIITDARADHAHGRAATRATLEDALADATPAIDTPMGRREALARMAARLRTQHRRVAGSRRRARLLARRLRRLHYLQRRSMHSNQPNGRPAVLAAIRKALDIKGIHDRAARARWERGMDLVARRESDYDASAVNDWDSNAARGTPSKGAWQFIAPTFAAYHQPGTSRDIHNLVAQACAFINYAMGRYGVAADASNLADRIQQADPHRAPKGY
>NZ_AP022590.1|WP_083099559.1|4312590_4314078_-|type-VII-secretion-protein-EccB
MPLSLSNRDQNSGHLFYNRRLRAATTRFSVRMKHDDRKQTAALALSILLVAIAAGWMLLLNVLKPTGIVGDSAIIGDRDSGALYARIDGRLYPALNLTSARLATGTANQPTWVKPAEIAKYPTGPLIGIPGAPAAMPVHRGATSAWAVCDTAGRPRSPERPVVTSIAGPLDGFDRATPLSDDAGVLVTFEGNTLVIWGGKRSQIDPSNRAITLSLGLDPGVTLPVEISRALYDALPATEPLGVPAVPLAGTPSTWVSGSQVGAVLQAQTASGGKQFYVLLPDGVQKVTSFVADLLRSANSYGSTAPRVVTPDVLVNIPEVNSLAVDYYPTRRLNFVDTAADPTTCVGWEKGSTDPQARVVVYNGRGLPSPSYMDNRIVHLVRDDRDPASVVANQVLVLPGAANFVTSTSGVVTSDSRESLFWVSDNGVRFGITNDDTTLRALGLDPGSAVQAPWPLLRTFAAGPALSRESALLARDTVPALGKVAVVTTSAKPGG
>NZ_AP022590.1|WP_083099561.1|4308363_4312587_-|type-VII-secretion-protein-EccCa
MSKKAFPINRVKIEPPKPVRVAPSAPIALPEREPRNIWVMIGVPALIVALIGTIVMLYVSGVRSLTTGFFPLMGIGAFSMLAFSGRFGRARKITWGEMEKGRRRYLRELDANRDEIQTAVCAQREWQNSVHSDPRGLGAIIGGPRMWERGRGDADFLEVRLGTGVQHAPDSVLSVTWPDIASDEELEPVTGQALRDFILEQRKIRDIAKVVNLRSAPGFSFVGDDLDRLRSLMRSVLCSLAVFHNPRDVKLMVVTRNPEAWSWIVWLPHNLHDELFDACGFRRLVFATPEELEEALGVELHMKGKRGAWTPLAAASPTAMGSTLETGTNTVDLGPHLVIVDDNTGSPDAWESVVGQVGKAGITLLRVASRVGTGVGFANDQVFNLSERHSAPSGSVNGDITLHRNGSDADGEDNRPAPLLRVNNKFFAHADQLSVHRAYRYARAMARWSPTSRSEIADSVSGATELLRALGISDPRDLDVDRLWAERRGRGDERWCEVPVGAKPNGELQNITIRAKDFGGFGFHSVVIGTSGSGKSEFFLSLVYGIALTHSPETFNVIFVDMKFESAAQDILGIPHVVAALSNLGKDERHLAERMRRVIDGEIKQRYELFTSVGARDANDYEEIRLAGRDLPPVPVLLVIVDEYLELFANHEKWINLIIHIGQEGRGANVFFMLGGQRLDLSSLQKVKSNIAFRIALRAESGDDSREVIGSDAAYHLPSKENGFGLLKVGPRDLEPFRCFYLSAPFVVPKTKEVATTVDMTLTKPRLYNWQFQPLDASDATALEAAAAVDAEPDEFLYYDDGFKRKKIVDVLRESLREVPHRSPRRPWLEPLEEPESIDALVAGYRGKPWHVDYGRNAGLMFPVGVMDIPEESKQIVHAVDALRSNVIVVGAKQRGKTTTLMTLMCSAATMYSPSRVTFFCIGGATLAQAASLPHVTDIVSPKDAEGIERILSSMDALIDAREDSFRRLKIDLDGFRERRFAPGSDGLGGTDANDPFGDVFVVVDDYDDLYSKDTVLGDRIISLSSRGPEYGVHVMCSAGGWIHGQRQSLLQNATARIQLRLADPSESQMGHSSLESRDAARRTLNRPGFGLTDSLHELRVGVPALTDASTGAMVSIVDVGARIAEVAGVTKHATLQRLPQRVALKAILEYEAAHPTAPQFQDLAISFAIGERHELGPVPIKLRESPGLMILGRQGCGKTMSLVAIGEAIMNRFSPEEAQLTLIDPKTAPHGLRDLHGPGYVRAYAYDQDEIDEVVTTLAQQVLLPRLPPKGLSQEELRALKPWEGPRHFVLIDDIQDLRPDQSYPPKPPVGAALWKLMERARQIGLHVFTTRNSANWATLQMDPWMRFQNSAKVAQLYMDNDPQNRINRNVRAQTLPPGRGLLVSVDGDVEGVLVGLPSSVIPPQQ
>NZ_AP022590.1|WP_083099563.1|4305527_4308383_+|RND-family-transporter
MHDRMGRFARLTGRYAVLIVGFWILAAAVANVAVPQLERVVDSHARSFMPPGAPSAVAAARAAQLFNQTPSNNFVYVVLERDQRLTPRDRQFYDALTGSLGSDQRHVYAVTDLWSQPATAAGAQSSDGKAVSVMVRLAGMLGTAQARDSVNAVRGTVQKLSPPVGLAVHVTGPGATIVDEFSAIDRQMLGITAATIGLILLLLLLVYRSPVAAAIPLTSVGLALALARAVVAALGQANVVEVSLFSVALMAAMTLGAGTDYAIFLVGRYHEGRRRGVAPAEALTQAYRSIAPVVIGSALTVSVALACLVFAKVGSFRSAGLPCAIGILATMVAALTLTPALMTLAIRRGYLEPRPSKTARRWRRVGAAVARWPGPILVTALALTLLVALPLVSMRVGFNEPAATPSSTDSNRGYASADRHFAANALLPNVVAIQADHDLRNPAGLIAIERITRHIMAVPGVRAVQSASRPDGKVPEQATLSYQAGVLGRQFGDTMDSLTQRLKRVTELDSALAQTQVAVDGLGIGLRGGSVGLAEVSGAAEDMRAGMEGLQRNVTTVSGYLDPLRDFVGRTPDCATNPICSTVDRVLQPVDSLVQTSTRLDSGAAKLTSGSSTAATAMATLPQSVVSMKDALGQARSAMHDLLSLSDTLGPQMRQLTDYMNEIATQFQGSAAADFYMPQRALSDPRYTTALRHLISESGRAAYLLVYGDGSEWGGEGAKRADQVRAAIKEATKEGTLTPTEVDLAGVGPVTADLQRFVAGDTTLLVGAALVLIFLIVTAMLRSPVAGLVVVGTVVTSYASAIGASVLIWQHLLHHDLHWAVAPIAFIALIAVGADYNLLLALRVKQEAAAGLKTGIIRAFGGTGGVVTIAGVIFGLTMLALLSSSVLSIAQIGTTIAVGLMVDTLVVRAFIVPSIVALLGRWFWWPRPLPRRAATSAVKRPDPQLVTAVAV
>NZ_AP022590.1|WP_083099544.1|4323162_4324605_-|CCA-tRNA-nucleotidyltransferase
MPEAAQDADLLTAAAVALNRHAPMLAELGSAFDAAGHQVYLVGGSVRDALLGRLSPDLDFTTDARPEQVQRILQRWADNLWDTGIEFGTVGVGKGDHRLEITTFRADTYDQVSRNPEVRFGDRLEDDLLRRDFTVNAMAVRITPEGPGEFLDPLGGLVALRARVLDTPAAPEVSFGDDPLRMLRAARFVSQLGFTVAPRVREAIDRMAPQLSRISAERVATELDKLVLGDDPTAGIDLLVQTGMGEVVLPEVGGMQMAIDEHHQHKDVYQHSLTVLRQAIALEDDGPDLVLRWAALLHDIGKPATRRHEANGGVSFHHHEVVGAKMVRKRLRALKYSKQMVEDISQLVYLHLRFHGYGDGKWTDSAVRRYVTDAGPLLSRLHKLVRADCTTRNKRRAARLQASYDRLEARIAELAAQEDLARVRPDLDGNQIMELLGIPAGPQVGEAWRFLKELRLERGPLDNDEATAELLAWWQSRGND
>NZ_AP022590.1|WP_083099541.1|4324738_4326268_+|hypothetical-protein
MHLRYISKAALIMFAGGDPWKIDATLQSGRPAQISNLAAAFHDAGQSTTEAEVAFRQARDRFDNAWTHENGENPINDSAEVRRATTSLGLQAAQLPKIGADLENVAAALAEAQRSGKGEIASLEGTLQGLDDQIGEAVELEKNPQLTASERQLLDHYINGLEKHAIGDTKASLNNLTQIRGQYSQQLQTSLANLRKQGEYQAPIQALDGEIPEGPPQTVSDEERRHNQIEAFKQVFGREPTSAADWETAAALDPQTYDPKFKGTKSQVEVVKIRPVPGQGVVRVSQWIEQRDVTSFPPWKRDLGNNRGPNPTFDPEDTKVTTYIDYENGLVVLRQNPSVEENSTGGPGQVKVGIPKGSVTQLPDGSVRIKYDAGNPFAPKVTGDPTGPFTGHTVTVNGDLVFTPGPGGVQVNGTRTDYPSLEVYQDLPNGGTRTVLIDPAQSGRSWGPAFNLPGHHDVGPIGGKAFTPFDTGGWNTKYDVPAPLPATEFGPVTDIPSVPPLPTGTAVPA
>NZ_AP022590.1|WP_083099571.1|4326390_4326627_+|hypothetical-protein
MLVTMWALGKGPFMTERGHTERSWMLIAVVITTVVSLALAAVLGKSPSPRNRGIALSIAGSSATVLIGGIIFAYLVLR
>NZ_AP022590.1|WP_142275789.1|4326662_4326938_+|hypothetical-protein
MPNSLYGPVTFAVAVLHVFIVEFATWLFMPYSIVFVLPAVLIYMAISALVMLAPGTVGQIGRGMLIGSLSGPLSLLIFGAAWAIAQAIGPI
>NZ_AP022590.1|WP_083099538.1|4327024_4327759_+|NUDIX-hydrolase
MSDGEQGKRRRRRGRRRGRGAATPSENQTTSQTTGDSTATKSRRPRATRRGPDQLRTVHETSAGGLVIDGLDGPRESQVAALIGRIDRRGRMLWSLPKGHIELGETAEQTAIREVAEETGIRGSVLAALGRIDYWFVTDGRRVHKTVHHYLMRFSGGELSDDDLEVAEVAWVPMGELPSRLAYADERRLARVADELIDKLQNDGPASLPPLPPSSPRRRPQTHSRTRHSDKPAASRKNGHGPGP
>NZ_AP022590.1|WP_083099536.1|4327755_4330155_+|hypothetical-protein
MTAARLRWAGLARIAAVLAIVAGIAVLTGPVIPRAAAGEPGVTPFVRVRIDQVTPDVVTTTSPPVVTVTGMVTNIGDRPVRDVMVRLEHAGAVTASAGLRTTLDGDTDGYQPAADFLTVAPELQRGQEVGFTLSAPLRALTKPSLGVEKPGIYPVLVNVNGTPDYGAPARLDNARFLLPAVGVPPDRADDVGSAVAPDTSKPVLITMLWPLADRPRLAPGVPGGTIPVRLVDDDLATSLASGGRLDILLASAEVATSHDVDPDGAVGRALCLAIDPDLLVTVNAMTAGYVVSNSPDGPAQLPGAPTHPGAGQATATEWLNRLRALAHRTCVTPLPYAQADLDAVQRVNDPGLSAIATTSANGIIDKILDVSSVRGATLVPDGPLTGRAVKLLSGNDNTVAIAAADLSAADSETGVDTAPRRLSAQVTVAPFDPAVGAALAGAGTAPDVPTYLDSSMTVRLGHDSVTARRQDALGSMFWQALRHDDPRTQILVPPTTWNLQADDAQVILTALATTIRSGLALPRPLPAVITEANQAAQAHPQPPEEVGAYTSARGQFNDDVTAGITGQVGRLWALTSSLMTDDRTGLTGVQYTAPLREDMLRALSQSEPPDTRNGLAQQRLAVVGKTINDLFGAVTIVNPGGSYTLATEHSPLPLALHNGLAVPIRVRLHVDAPPGMNVTDVGQIELPPGYLPLRIPIEVNFTQRVAVDVTLRTADGLRLGEPVRLSVHSNAYGKVLFAITLSAAAVLVLLAGRRLWHRFRGQPDRADLDRPDPPDARHAAGPGETRDDADRRAEEEHRV
>NZ_AP022590.1|WP_083099529.1|4334538_4335309_+|hypothetical-protein
MDAADDEAANDRSAESEPALTVHLLADLQAGILDDESAARVRRQVRADPQAAGVLGALNQVRHDVAAVGADSGAAPDPPPEVAARISAALRSAETASGEAAGPAVHSARPHIRPARTIAAVAGLCAVLAAIGFGTVALLHAPEPAPDTPGDVQHITVSTPPMEIPLSQHEILGLLDRSPDYGALSDPARRASCLTGLGYPASTQVLGARPVEINARPGVVLVIPGDSPHVLAVYAVSPNCSAADTGLLANTQVPRL
>NZ_AP022590.1|WP_163650869.1|4335395_4336406_+|thioredoxin-disulfide-reductase
MTADTVHDVIVIGSGPAGYTAALYTARAQLAPVVFEGTSFGGALMTTTEVENFPGFRDGITGPELMDQMREQALRFGADLRMEDVESVSLQGRVKTVTTSEGQTHRARSVILAMGAAARYLGVPGEQELLGRGVSSCATCDGFFFRDQDIAVIGGGDSAMEEATFLTRFARSVTLVHRREEFRASRIMLERAKASDKITIVTNKAVEAVEGEQTVTGLRLRDTVSGEVSTLAVTGVFVAIGHDPRSELVREVLETDPEGYVLVRGHTTATSIDGVFAAGDLVDRTYRQAVTAAGSGCSAAIDAERWLADHEESSAAAQGDATEFPGSTDTLIGAPQ
>NZ_AP022590.1|WP_083095088.1|4336402_4336756_+|thioredoxin
MTDAEKAGATLEVSDASFSTDVLSSNKPVLVDFWATWCGPCKMVAPVLEEIASERGEHLTVAKLDVDANPETAQNFQVVSIPTMILFKDGQPVKRIVGAKGKAALLRELSDAVPNLS
>NZ_AP022590.1|WP_083095089.1|4336888_4338112_+|peptidoglycan-binding-protein
MSSPRREYGDALRCGDRSAAVTEIRATLATLGLLDGSEDDLDTGRHVALELFDAELDQAVRAFQQHRGLLVDGIVGEATYRALKEASYRLGARTLYHQFGAPLFGDDVATLQARLQDLGFYTGLVDGYFGLQTHNALMSYQREYGLSADGICGPETLRSFHFLSSRVTGGSPHAIREEELVRSSGPKLSGKRIIIDPGRGGADHGTIMQGPSGPVSEADVLWDLASRLEGRMAAIGMETFLSRPVNRSPLDAERAATANNVGADLMISLRCETQVNAAANGVASFHFGNSHGSVSTIGRNLADFIQREVVARTGLRDCRTHGRTWDLLRLTRMPTVQVDVGYITNPRDRSMLVSTQTRDAIAEGILAAVKRLYLLGKNDRPTGTFTFAELLAHELSVERTSHLGGSN

Crispr_ID: NZ_AP022590_12

• CRISPR_ID: NZ_AP022590_12
• CRISPR_location: 5466106-5466247
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_AP022590_12

Consensus_repeat	Method
CCGCCGGCTGCGGCTCCGCTGCCCG	CRISPRCasFinder

spacers of NZ_AP022590_12

>12.1|5466131|32|NZ_AP022590|CRISPRCasFinder
GACCGGGGAACTATGGACCGCTGCCCGGACCG
>12.2|5466188|35|NZ_AP022590|CRISPRCasFinder
GGCCACCGCCTGGTGCGGCTCCGCTGCCCGGCCCC

CRISPR arrays and Neighbor proteins around NZ_AP022590_12

CRISPR arrays

The CRISPR arrays of NZ_AP022590_12

>merge|NZ_AP022590|12|5466106-5466247|CRISPRCasFinder
CCGCCGGGTGCGGTACCGGCACCGGGACCGGGGAACTATGGACCGCTGCCCGGACCGCCGCCGGCTGCGGCTCCGCTGCCCGGGCCACCGCCTGGTGCGGCTCCGCTGCCCGGCCCCCCGCCGGCTGCGGCTCCGCTGCCCG

>NZ_AP022590|12|11|5466106-5466247|CRISPRCasFinder
CCGCCGGGTGCGGTACCGGCACCGG	GACCGGGGAACTATGGACCGCTGCCCGGACCG
CCGCCGGCTGCGGCTCCGCTGCCCG	GGCCACCGCCTGGTGCGGCTCCGCTGCCCGGCCCC
CCGCCGGCTGCGGCTCCGCTGCCCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022590.1|WP_083093653.1|5466309_5468109_+|MCE-family-protein	unknown	unknown	gnl|CDD|224380
NZ_AP022590.1|WP_083093647.1|5469457_5470255_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083093645.1|5470467_5470857_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083093661.1|5461404_5462427_+|MCE-family-protein	unknown	unknown	gnl|CDD|273384
NZ_AP022590.1|WP_083093665.1|5459279_5460125_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|223838
NZ_AP022590.1|WP_083093634.1|5473731_5474013_+|cytochrome-C-oxidase-subunit-IV-family-protein	unknown	unknown	gnl|CDD|377083
NZ_AP022590.1|WP_083093641.1|5471564_5472350_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083093643.1|5470865_5471462_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NZ_AP022590.1|WP_083093639.1|5472346_5473153_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083093637.1|5473149_5473728_+|cytochrome-c-oxidase-subunit-3-family-protein	unknown	unknown	gnl|CDD|239213
NZ_AP022590.1|WP_083093649.1|5468819_5469461_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083093663.1|5460145_5461408_+|MCE-family-protein	unknown	unknown	gnl|CDD|378749
NZ_AP022590.1|WP_083093673.1|5455341_5456868_+|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|143408
NZ_AP022590.1|WP_083093671.1|5456864_5458070_+|CoA-transferase	unknown	unknown	gnl|CDD|367110
NZ_AP022590.1|WP_008253744.1|5454099_5454300_-|ferredoxin	unknown	unknown	gnl|CDD|379145
NZ_AP022590.1|WP_083093659.1|5462426_5463545_+|MCE-family-protein	unknown	unknown	gnl|CDD|273384
NZ_AP022590.1|WP_083093658.1|5463541_5464960_+|MCE-family-protein	unknown	unknown	gnl|CDD|273384
NZ_AP022590.1|WP_067832297.1|5454358_5455060_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|235546
NZ_AP022590.1|WP_083093651.1|5468166_5468688_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083093667.1|5458453_5459272_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|223838

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP022590.1|WP_083093653.1|5466309_5468109_+|MCE-family-protein	gnl|CDD|224380	COG1463, Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism].	4.13198e-56
NZ_AP022590.1|WP_083093634.1|5473731_5474013_+|cytochrome-C-oxidase-subunit-IV-family-protein	gnl|CDD|377083	pfam03626, COX4_pro, Prokaryotic Cytochrome C oxidase subunit IV. Cytochrome c oxidase (COX) is a multi-subunit enzyme complex that catalyzes the final step of electron transfer through the respiratory chain on the mitochondrial inner membrane. This family is composed of cytochrome c oxidase subunit 4 from prokaryotes.	0.0016813
NZ_AP022590.1|WP_083093661.1|5461404_5462427_+|MCE-family-protein	gnl|CDD|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	5.79432e-61
NZ_AP022590.1|WP_083093665.1|5459279_5460125_+|ABC-transporter-permease	gnl|CDD|223838	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	1.80145e-65
NZ_AP022590.1|WP_083093643.1|5470865_5471462_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	8.48887e-13
NZ_AP022590.1|WP_083093637.1|5473149_5473728_+|cytochrome-c-oxidase-subunit-3-family-protein	gnl|CDD|239213	cd02862, NorE_like, NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of nitric oxide reductase (NOR). Based on this and on its similarity to subunit III of cytochrome c oxidase (CcO) and ubiquinol oxidase, NorE has been speculated to be a subunit of NOR.	1.99653e-63
NZ_AP022590.1|WP_083093663.1|5460145_5461408_+|MCE-family-protein	gnl|CDD|378749	pfam11887, Mce4_CUP1, Cholesterol uptake porter CUP1 of Mce4, putative. Mce4_CUP1 is a family of putative Mce4 transporters of cholesterol. The domain is found associated with pfam02470. The full TCDB classification for this family in conjunction with PF02470 is TC:3.A.1.27.4.	4.58423e-64
NZ_AP022590.1|WP_083093673.1|5455341_5456868_+|aldehyde-dehydrogenase-family-protein	gnl|CDD|143408	cd07089, ALDH_CddD-AldA-like, Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins. The 6-oxolauric acid dehydrogenase (CddD) from Rhodococcus ruber SC1 which converts 6-oxolauric acid to dodecanedioic acid; and the aldehyde dehydrogenase (locus SSP0762) from Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 and also, the Mycobacterium tuberculosis H37Rv ALDH AldA (locus Rv0768) sequence; and other similar sequences, are included in this CD.	0
NZ_AP022590.1|WP_083093671.1|5456864_5458070_+|CoA-transferase	gnl|CDD|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	1.31827e-92
NZ_AP022590.1|WP_008253744.1|5454099_5454300_-|ferredoxin	gnl|CDD|379145	pfam13370, Fer4_13, 4Fe-4S single cluster domain of Ferredoxin I. Fer4_13 is a ferredoxin I from sulfate-reducing bacteria. Chemical sequence analysis suggests that this characteristic [4Fe-4S] cluster sulfur environment is widely distributed among ferredoxins.	1.22514e-12
NZ_AP022590.1|WP_083093659.1|5462426_5463545_+|MCE-family-protein	gnl|CDD|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	3.49944e-50
NZ_AP022590.1|WP_083093658.1|5463541_5464960_+|MCE-family-protein	gnl|CDD|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	3.63679e-64
NZ_AP022590.1|WP_067832297.1|5454358_5455060_-|SDR-family-oxidoreductase	gnl|CDD|235546	PRK05653, fabG, 3-oxoacyl-ACP reductase FabG.	8.02538e-89
NZ_AP022590.1|WP_083093667.1|5458453_5459272_+|ABC-transporter-permease	gnl|CDD|223838	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	1.9389e-77

Protein sequences

>NZ_AP022590.1|WP_083093658.1|5463541_5464960_+|MCE-family-protein
MTSRIPRKRLAAVTAVVLVGLIVAGAAVVVRNTFFGPRTITAYFTTATAIYPHDEVRVSGVKVGNIKSIQPQGTQAKMVLTVDHDVPIPADAKAVIVAPNLVASRYVQLTPAYRDTGPVMHDGAVIPVERTAVPVEWDEVKTQLMRLATDLGPKSGVSGTSVGRFIDSAANALDGNGDKLRQTLGQLSGVGRILANGSGNIVDIIKNLQTFVAALRDSNVQIEQFNGRLATLTSVVNDSKSDLDAALTDLSTAVGEVQRFIAGTRNQTSEQIARLADVTQNLVDHHMALENILHAAPNAFGNFFNDYNADTGTIVGGFGLMNMANPTWGGQVLLSTPGCTQIGAIENITAVESGKLCSLFLGPGLRQTSWNNSPIPINPFIAKSIDPSRVLYTEPRLAPGGEGPKPAAPEIPPAVSAFTGLPGDPVGPPGAVPPERIPGAAMPLPPPPSTPVPPPPAPSTSGMLLPADGPQQ
>NZ_AP022590.1|WP_083093659.1|5462426_5463545_+|MCE-family-protein
MLKYRGAQLVKPGLIGVILAVMVILVGLSPDRFIQWATMVRYQALFTEAGGLATGNPVIVSGMKVGTVSDVKLRHGDALVTFAMKGNILLGSETSAHIRTGTLLGERMLTVESAGTGTMHPMALIPVSRTSSPYSLTEAVSDLTSDTAGTNTTALNQSLDTLAATLDQIAPQMGPAFDALTRLSRTLNSRNKNLGELFKSAGDVTGILSERSMQVNKLILNSDSLLQVLVARRQEIVDLLANTSVVAKQLTALVHENESTLAPTLERLNRVTGVLEKNRDNIGKALPGLAKFQITVGEAISGMYAYQAFAPNFLIPQLFQELVDYLWGFRTFDTSKGPGFPSPVPRALTPWPYNSIPLCPGCTLGGRIGGSQ
>NZ_AP022590.1|WP_083093661.1|5461404_5462427_+|MCE-family-protein
MRTRATLIKFGIFAVVMAMLTAFLFFIFGQYRTGATTEYSAVFTDVSRLKTGQSVRVAGIRVGTVNSVSLQPDKKVVVKFDADRSVVLTEGTRAAVRYLNLVGDRYLELVDGPGSPKHLPAGGQIPVNRTAPALDLDLLLGGLKPVTQGLNARDVNALTSGLLQVFQGQGGTLDSLFAKTTSFSNALADNDQTVQQLIDNLNIVIGTVSNDGKQFSGAIDRLEQLVSGLSNDRDTIGSAIDALDKGTASLADLLAEARPPLSGTIAQLNRLAPILDGDKDRLDAALQKAPQNYRKLVRLGVNGATIPYYICQFGLRGTDLNGKTVRANIFRSDAGRCTEP
>NZ_AP022590.1|WP_083093663.1|5460145_5461408_+|MCE-family-protein
MTQSVPAGRGAVAGRPARTGHARPPAGRNYVPPLLGLTTVVIIGLIFAVAVGLFQGSFTETVPVTVISQRAGLVMNPDAKVKMRGVQVGKVASIQSLPNGQAAIHLAMDPSQLHFIPGNVLVNIASSTVFGAKSVELVEPDQPSAQRLHSGQTLQGQHVMVEINTVFQQLVSVLSHIDPPKLNESLGALAQAFSGRGPQLGQSLSDLDSFLARLEPSLPAFRHDLAVLPAVSNAYADAAPDLVKTAANATRISKTLVDEQHNLDALLISAIGLADIGNDVLSTNRQPLTDVLHLLVPTTDLTNEYNPALTCAFGGLIQIAHGAPLSEPSINISASLTWGAERYRYPTNLPKVAATGGPQCVGLPHLPFNTAPPQLITDTGANPVNYGNPQLLINSDLLKQLLYGPIAGPPRNSAQIGQPG
>NZ_AP022590.1|WP_083093665.1|5459279_5460125_+|ABC-transporter-permease
MALRAAYPRLTRQLERPVAFMGRIGDHTLFYGKALAGVPFAATHYTREVIRLIAEISMGAGTLAMIGGTVVIVGFLTLAAGGTLAIQGYTSLGNIGIEALTGFLSAFINVRIAAPVVAGIGLAATFGAGVTAQLGAMRINEEVDALESMAIRPVAYLVSTRILAGMMAITPLYSIAVILSFVASQFTTTFLLGQSQGLYQHYFNTFLNPIDLLWSFLQAILMALTILLIHTYYGYFASGGPAGVGNATGNAVRTSLIVVVSVTLLVSLSIYGTNGNFNLSG
>NZ_AP022590.1|WP_083093667.1|5458453_5459272_+|ABC-transporter-permease
MATKGADHWSAGLPQLKLKWDLSGPMQAVGALFAMSADAVKFLFRRPFQWREFLEQSWFVARVSLAPTLLVAIPFTVLVSFTLNILLRELGAADLSGAGAAFGAVTQLGPLVTVLIVAGAGATAMCADLGSRTIREEIDAMEVLGINPIQRLVTPRMLASGLVAFLLNSLVVIIGVLGGYVFSVFVQDVNPGAFAAGITLLTGVPEVVISCVKAALFGLIAGLVACYRGLSITGGGAKAVGNAVNETVVYAFMSLFVVNVVVTAIGIKMTAK
>NZ_AP022590.1|WP_083093671.1|5456864_5458070_+|CoA-transferase
MRPLEGIRVLEVAMYGFVPSAGAVLAEWGADVVKVEHAVTGDPQRGLRQTGMLRVEGDPNPNIEHANRGKRSIGLDMSVPEGKEVLYELARRADVFLTSFLPDHRKKFGIDVEDIRAINPKIVYARGSALGPRGEESTKGGYDMTAFWCRAGTAATITPAGMPGMIAPPGPAYGDTISGTNLAGGIAAALLKRERTGEPSVVDVSLLGSGLWSLGHTVALTKHLGQRLESPPPGVHGAPNNPLVGLYTTSDGRYISFVMMQPTKFWADVCRHVDLPELADDPRFDTVENIAANTPDAVELLTKAIAARTLAEWSERFATLSGPWAPVQDTLQAADDAQIRANEYMVQAGELELVANPVQFDVAAPQTGPAPGFAEQTDEILIELGLDWDRIIELKTAGAVT
>NZ_AP022590.1|WP_083093673.1|5455341_5456868_+|aldehyde-dehydrogenase-family-protein
MPAQDTAEPVAQTVAGAAPESHVDRRLLIDGRLVSADKTFPSVNPATGAVIGHAPDAGGAEAQAAIAAARRGFDTTSWPTDVELRIRCLDQLHRALVDHADELRELTIAEVGATRALTQGAQLDDPIGIVRFYADLLRTYEFSEDLGERESRGMRHHRWVEKEAAGVVGAIIAYNYPNQLALAKLAPALAAGCTVVLKGAPDTPLVTLALGELIANHTDIPAGVVNVLSSSDPASGVALTTSPDVDVITFTGSTAVGRKIMAASSDTVKRVFLELGGKSAAIMLDDADFANAALFAAFSMVTHAGQGCALTSRLLVPKSHHDEIVELIAQNFAKVRHGDPADPTTYMGPLINEQQRDKVDGMVQRAVAAGATLVTGGRRLDPGYFYAPTLLTNVDPDSEIAQDEIFGPVLVVIAFDDDDDAVRIANNSIYGLAGAVFSRDQDRALAVARRIRAGSFSINGGNYFGADAPFGGFKQSGVGREMGVAGLEEFLESKTFAVPAVSAKGAGA
>NZ_AP022590.1|WP_067832297.1|5454358_5455060_-|SDR-family-oxidoreductase
MKTAVVTGGGSGIGLAVVQRLRADGLNVASIDLRPSEGDFAFTADVTDRSQLDAALSAIRAQLGPVTVLVNAAGLDGFKKFNNITFEDWHRVIDVNLNGVFHTVQAVLPDMVEAGWGRIVNISSSSTHSGAPYMSHYVAAKSAVNGLTKSLALEYGPKGITVNAVPPGFIDTPMLRAAEKNGFLGDIDETIARTPVRRMGTPEDIAAACAFLVSEEAGYITGQILGVNGGRNT
>NZ_AP022590.1|WP_008253744.1|5454099_5454300_-|ferredoxin
MKVWVDSERCQGHTLCAMIAPESFQLSDIDGSSSAIDEVVPADREDQVREAAQSCPEQAIMITDDA
>NZ_AP022590.1|WP_083093653.1|5466309_5468109_+|MCE-family-protein
MLTRFVRIQLAIFTIAGTIGVISMILFYIQAPTLLGIGRMTVTLELPATGGLYRFSNVTYRGVQLGKVTAVGLTPTGAKATLSLSTSPKVPADLTAAVLSVSAVGEQYVDLQPKTDSPPYLHDGSVIAVRDTTIPQPVAPMLEQVNALVQSIPKTKLGQLLDESFQGFNGTGYDLGSLIDSSKTLSRDANGVVDRTKALTEDTGPLLDTQARTTDSIRTWARSFAGISDTLVNNDSHFRTILQTGPDTANEASRLLEQIKPTLPVLLANLTTIGQIGITYHPSIEQLLVLLPSGVAIEQAAQGENHPDGRAYGDFAATVDDPPICTVGFMPPNTWRSPDDLTDIDTPDGLYCKLPQDSPIAVRGARNYPCMGHPGKRAPTVEICNSDKPYMPLAMRQHTLGPYPLDPNLLAQGVPPDDRITTNDRIFGPVEGTPLPPGAVPRGTPAGPRGENPPPGTVGAAVPPSPSSGPSLPMSRMSADLPPIAPLDVPVAGELPRPAAPPAPVFSPDPAPGDSAPAIPAPANPAPANPAPADTAGGGGPQAAPSSFGANASKPAPSVVVAKYDSRTGRYVGPDGKLYQQSDLVAPKAPKTWKDMLPT
>NZ_AP022590.1|WP_083093651.1|5468166_5468688_-|hypothetical-protein
MRSVKTLTTATLVAAIAFGGLSTASTARAITKEDVAINGTFRATSIGDWAQRNDQYFGEPTVYQTWTISSTCESTMECHGTVTSDQGWSAPLYMKDGEMWKVRREVPDWERCEDGTAFPGVQTFFFYPVNDNGGFQIGSRVLSGKDKTVGPSGACGQNNWLDIAMPLRLDQLS
>NZ_AP022590.1|WP_083093649.1|5468819_5469461_-|hypothetical-protein
MTLEPDSSPDGTEKAIDGAHPSPADDDGLAPAGAGPARLRRLAAIRRGARRYSARWRSILATTLVIAAVGVAAGVYVILYRPDQQVGDAAAHRAIQAASDGAVAVLSYSYDHLNRDFSNAKSHLTGDLLAYYSKFSDDVVAPTAQKGQLTASAKVIRAAVSELHPDSAAVLVFVDQTTKSAQKKDPENTQSSVLVTLSKVNGSWLIAKFDPAG
>NZ_AP022590.1|WP_083093647.1|5469457_5470255_-|hypothetical-protein
MHDPERPNADDRGDPRDVRNPDEPRSSPGAGSGDVAAASEGDPEDEVAKAEARAEAARARLESLRGAAETGDAEDAHDVEQRPAASTRRRLRLPRRPRRPRWLRRPRRKTVAAGIGIVLFSTSLAASGYMLWQHHTAVHNRQLAAEFSAAARQGITAFMSIDPDHAKESVQRTIDASTGDQKDQLSVLSTLMVQKAEETKVGTKVTIEAVAVESFSDNSGVVLVAAKTDPIGPDNAKPPPALFRLSVNLDRDDGKLKMSKVDFLR
>NZ_AP022590.1|WP_083093645.1|5470467_5470857_+|hypothetical-protein
MALVAALLGAGAVAAPPATAGPTVCDYPTCTPGIMPHQVLGAPCDNTTYYAFGVADGYVSFASEPGRLMFCGSPRRYQPRWFRSPPMAGVKDENADCQNYLNYVAQAPDGLFLICIAHDGISSWVRADT
>NZ_AP022590.1|WP_083093643.1|5470865_5471462_-|TetR/AcrR-family-transcriptional-regulator
MGTARQPVTGEQFWLIEHSAARTRVLDAALDLFATHGVSGTSLQMIADAVGITKAAVYHQFRTKEQIVIAVTERELGRLEPALEAAEAYDDGPQARDALLVGVVEMAVRDRRLVRTLQFDPVVVRLLAEHKPFQVFMDRLYQVLLSDAGLDGRIEAAMFSGALSTAVMHPLVADIDDDTLLERVTDLSRRLLGLPRKP
>NZ_AP022590.1|WP_083093641.1|5471564_5472350_+|hypothetical-protein
MSDIGGNDADGRQSARTAPRRTDGELILLWTLPAALILWIASFFLFPGFNPPMSPTMPAEQVAAFYRDPSHIPQIRSSMILFNWFGVCLVPILALIVLQIRRMAHRTPIFSYAMLGCAAGGPTLFLVANVCWLLAAFRPERSPELTQLLNDLGWMTFTILVPFLIGQSVILAVAIYFDDQPRPVFSRWVAHFNLVVAAALVPAAFVGVSLTGPLAWDGFLSFWVKNVAIAVWIVVMGVVLGQSIYRERAENPRRADEVITA
>NZ_AP022590.1|WP_083093639.1|5472346_5473153_+|hypothetical-protein
MSAVITPPTAPPSGPLYRRIGWHLWHGPKRELWLAWAALLFFYNLFFPMFFIVAQVQPPPEPTWDLATQVRWFSERHLGIPVGFGIIFAISGLIATNNALIAYSMRRMSVSRAFAYSYLLIYSLSAVPGMLLLNIALIVGTLRPDRDPRLIGWLYDFAFLSFDGTMGVFLIGSLIWMVAILLDKNRVFPKWFGYLNLCNALTEVVVAPCWIFRRGVFAWDGEIAWWLDMVVFGIYQVTFIVMLFQMIRREDFGTGELPVPPRRKAVAQ
>NZ_AP022590.1|WP_083093637.1|5473149_5473728_+|cytochrome-c-oxidase-subunit-3-family-protein
MTDLADKRGGVRAVPGQPDMWAFVLFETLLFTAYFGFYLFSRGRNPELFLQSQAHLDLRVGVFNTLFLLLSSWSVARCVQSARAGAYRAALRDVLITAALAVVFLFLKVFEWARLVHTGNGVASNDFFMYYFFLTGIHFVHLLIGFVVLGVIVYQLRSPMRRSQELVETGATYWHTVDFLWVLIFALLYVVR
>NZ_AP022590.1|WP_083093634.1|5473731_5474013_+|cytochrome-C-oxidase-subunit-IV-family-protein
MKFNKRLLVVWVILAALTLGYLWIDRSVDGALKSSAVVTSSVIVIALVKVRIIFREFMEVRDAPVLLCRLTDAWVVLIGIVLLGCYFAGMQVR

Crispr_ID: NZ_AP022590_13

• CRISPR_ID: NZ_AP022590_13
• CRISPR_location: 6181071-6181151
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP022590_13

Consensus_repeat	Method
GGCGAAGGGGGTCGCCACGATCCG	CRISPRCasFinder

spacers of NZ_AP022590_13

>13.1|6181095|33|NZ_AP022590|CRISPRCasFinder
GCCAGCGTGGCGATCGTGAGCGCGGCGGCGCCA

CRISPR arrays and Neighbor proteins around NZ_AP022590_13

CRISPR arrays

The CRISPR arrays of NZ_AP022590_13

>merge|NZ_AP022590|13|6181071-6181151|CRISPRCasFinder
GGCGAAGGGGGTCGCCACGATCCGGCCAGCGTGGCGATCGTGAGCGCGGCGGCGCCAGGCGAAGGGGGTCGCCACGATCCG

>NZ_AP022590|13|12|6181071-6181151|CRISPRCasFinder
GGCGAAGGGGGTCGCCACGATCCG	GCCAGCGTGGCGATCGTGAGCGCGGCGGCGCCA
GGCGAAGGGGGTCGCCACGATCCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022590.1|WP_083092752.1|6169763_6170057_-|DUF732-domain-containing-protein	unknown	unknown	gnl|CDD|368380
NZ_AP022590.1|WP_163650925.1|6174004_6174304_-|DUF732-domain-containing-protein	unknown	unknown	gnl|CDD|368380
NZ_AP022590.1|WP_083092742.1|6176150_6176480_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_163650929.1|6178334_6178757_+|DUF3349-domain-containing-protein	unknown	unknown	gnl|CDD|371747
NZ_AP022590.1|WP_163651025.1|6184615_6185422_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224044
NZ_AP022590.1|WP_158086041.1|6170087_6170483_-|DUF732-domain-containing-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083092743.1|6175149_6176154_-|tyrosine-type-recombinase/integrase	unknown	unknown	gnl|CDD|234698
NZ_AP022590.1|WP_083092745.1|6174711_6174930_-|hypothetical-protein	unknown	unknown	gnl|CDD|237560
NZ_AP022590.1|WP_163650788.1|6176476_6177019_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_163650927.1|6174566_6174719_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP022590.1|WP_083092738.1|6177672_6177933_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP022590.1|WP_163650925.1|6174004_6174304_-|DUF732-domain-containing-protein	gnl|CDD|368380	pfam05305, DUF732, Protein of unknown function (DUF732). This family consists of several uncharacterized Mycobacterium tuberculosis and leprae proteins of unknown function.	9.18387e-14
NZ_AP022590.1|WP_163650929.1|6178334_6178757_+|DUF3349-domain-containing-protein	gnl|CDD|371747	pfam11829, DUF3349, Protein of unknown function (DUF3349). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 99 to 124 amino acids in length.	2.50673e-22
NZ_AP022590.1|WP_163651025.1|6184615_6185422_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	5.93844e-111
NZ_AP022590.1|WP_083092743.1|6175149_6176154_-|tyrosine-type-recombinase/integrase	gnl|CDD|234698	PRK00236, xerC, site-specific tyrosine recombinase XerC; Reviewed.	1.43392e-25
NZ_AP022590.1|WP_083092745.1|6174711_6174930_-|hypothetical-protein	gnl|CDD|237560	PRK13922, PRK13922, rod shape-determining protein MreC; Provisional.	0.00065343
NZ_AP022590.1|WP_083092752.1|6169763_6170057_-|DUF732-domain-containing-protein	gnl|CDD|368380	pfam05305, DUF732, Protein of unknown function (DUF732). This family consists of several uncharacterized Mycobacterium tuberculosis and leprae proteins of unknown function.	2.10432e-05

Protein sequences

>NZ_AP022590.1|WP_163650929.1|6178334_6178757_+|DUF3349-domain-containing-protein
MTNTAASHTSNFCRSVLRWLRAGYPRASRARPRAAAGPAAQHPLTEEQITEVVRNITADGSPAIADGVIDRDEIAHFISDMTHYDAGPENIIRVAATLAAVGWPLAGIDVSEVIPGDEWGEAAEIAARGHAPEGASGVGV
>NZ_AP022590.1|WP_083092738.1|6177672_6177933_-|hypothetical-protein
MSATGAPLIVSGILGVGEIAVGAYQHHHANKIAWKPQHSRGGLGLLAAVGATTGQLENAFPAAVLGGVAVGVNLINQTHQQRQQSA
>NZ_AP022590.1|WP_163650788.1|6176476_6177019_-|hypothetical-protein
MTPENNTQCWRDLADQLTPQQVAELEEREAGYRHRATLPEDPWTSWEPRTDRAIEDALLHDGRRHAHDNLIAALMSDVPPLPDAKTFGYWETDDEHLCRFVSTPTRSVDGTKIRVLGAASQLADGSILIAQGIDVPQVRIDELSRDGYMTEVFTLSPGQARNLAAALLNTADQIDGWIAR
>NZ_AP022590.1|WP_083092742.1|6176150_6176480_-|hypothetical-protein
MTSPDRWRELTDAVIGHVAKPAGAVSVEEWADALTPDAFRLFYGPTRAVELGHGATMEVVTRGTQSCDGRIEDHGILVHGGSDESITATSARALAAALTEAAREIESLR
>NZ_AP022590.1|WP_083092743.1|6175149_6176154_-|tyrosine-type-recombinase/integrase
MNAVNRARIARKRAQRLGLHLSQRGIVFTVRDDNDVTLAVGPLAVVDRYLLDRIRPKPPGPQPSISAPETWQRYIDDYLLTLSAAGQRPATFRLRKGILCRVARGLGCPPGEVTADKLVDWFGRQQQLSPEGRHSYRSTLRGFFVWMYETDRIPVCIADALPTVRVPKAPPRPATDEAWVAALERADQRMELMLRLAAEAGLRRAEVAQVHSRDLIDVDGGRRLLVRGKGGQNRMVPVSDYVAALIRESGDGWAFPNKAGGHLTAEHVGKLVARALPDNWTMHTLRHRYATRVYRGSRNIRAVQQLLGHTSVISTERYVAIYDDEIRAAAACAW
>NZ_AP022590.1|WP_083092745.1|6174711_6174930_-|hypothetical-protein
MTDDELPQDEAFKAERARLFAEIATLKDQRNELQRQLAECQRENSRLRAQPLAELPDSRDTADPDAEDNERE
>NZ_AP022590.1|WP_163650927.1|6174566_6174719_-|hypothetical-protein
MSDDTVAGTTPGAGDAETEIVPLPTTEAPELAWSREAEETEVFSRSWCGC
>NZ_AP022590.1|WP_163650925.1|6174004_6174304_-|DUF732-domain-containing-protein
MPIIPKNPSAAELQQALVAIFDRDGIPYGSPTAASADADSVCEYLDSGHRSFADLVAWIRRARPSLMSDQVGGFAGASIGVYCPRYGYLIDSTNEGATS
>NZ_AP022590.1|WP_158086041.1|6170087_6170483_-|DUF732-domain-containing-protein
MAMALLVMAGLGPGRAHADPGPGYCGARQDALDCVPYDGPAPPPPTPAEASFLRAGRSYAPSADDATLLRIGRGTCNMLRGGSSTNYVVHDIARHLAMSNQGADQVMDAAMGNICPDVHIGANGADDSRPH
>NZ_AP022590.1|WP_083092752.1|6169763_6170057_-|DUF732-domain-containing-protein
MRSVITLVGVAASALLIATAAPARADGASYIQYLNDHNIFVPGINDAVRISRGSQVCVSLHNGMTPQQIIDANPIVYFDLRGVIDAAQHELCPDTLH
>NZ_AP022590.1|WP_163651025.1|6184615_6185422_+|ATP-binding-cassette-domain-containing-protein
MLLDFRQVSLRRGGNVLVGPLDWAVELDERWVIVGPNGAGKTSLLRIAAAAEHPSSGIAFVLGERLGRVDVTELRSRIGLSSSALAQRIPTDEVVRDLVVSAGYAVLGRWRERYDDVDYRRAIDMLESLGAEHLADRTYGTLSEGERKRVLIARALMTDPELLLLDEPAAGLDLGGREELVARLADLAADPDAPALVLVTHHVEEIPPGFSHCMLLSGGEVVAAGLLTDVMTSENLSTAFGQAIALEVVDGRYFARRVRTRAAHRRPL

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_AP022590_3	3.1|188252|33|NZ_AP022590|CRISPRCasFinder	188252-188284	33	NZ_AP022590.1	192234-192266	0	1.0
NZ_AP022590_3	3.1|188252|33|NZ_AP022590|CRISPRCasFinder	188252-188284	33	NZ_AP022590.1	195434-195466	0	1.0
NZ_AP022590_3	3.2|188312|57|NZ_AP022590|CRISPRCasFinder	188312-188368	57	NZ_AP022590.1	192294-192350	0	1.0
NZ_AP022590_3	3.3|188396|57|NZ_AP022590|CRISPRCasFinder	188396-188452	57	NZ_AP022590.1	192378-192434	0	1.0
NZ_AP022590_3	3.4|188480|57|NZ_AP022590|CRISPRCasFinder	188480-188536	57	NZ_AP022590.1	192462-192518	0	1.0
NZ_AP022590_3	3.5|188564|57|NZ_AP022590|CRISPRCasFinder	188564-188620	57	NZ_AP022590.1	192546-192602	0	1.0
NZ_AP022590_5	5.1|194450|33|NZ_AP022590|CRISPRCasFinder	194450-194482	33	NZ_AP022590.1	192234-192266	0	1.0
NZ_AP022590_5	5.1|194450|33|NZ_AP022590|CRISPRCasFinder	194450-194482	33	NZ_AP022590.1	195434-195466	0	1.0
NZ_AP022590_5	5.2|194510|57|NZ_AP022590|CRISPRCasFinder	194510-194566	57	NZ_AP022590.1	192294-192350	0	1.0
NZ_AP022590_5	5.3|194594|57|NZ_AP022590|CRISPRCasFinder	194594-194650	57	NZ_AP022590.1	192378-192434	0	1.0
NZ_AP022590_5	5.4|194678|57|NZ_AP022590|CRISPRCasFinder	194678-194734	57	NZ_AP022590.1	192462-192518	0	1.0
NZ_AP022590_5	5.5|194762|57|NZ_AP022590|CRISPRCasFinder	194762-194818	57	NZ_AP022590.1	192546-192602	0	1.0
NZ_AP022590_3	3.4|188480|57|NZ_AP022590|CRISPRCasFinder	188480-188536	57	NZ_AP022590.1	184259-184315	1	0.982
NZ_AP022590_5	5.4|194678|57|NZ_AP022590|CRISPRCasFinder	194678-194734	57	NZ_AP022590.1	184259-184315	1	0.982
NZ_AP022590_3	3.5|188564|57|NZ_AP022590|CRISPRCasFinder	188564-188620	57	NZ_AP022590.1	184343-184399	2	0.965
NZ_AP022590_5	5.5|194762|57|NZ_AP022590|CRISPRCasFinder	194762-194818	57	NZ_AP022590.1	184343-184399	2	0.965

1. spacer 3.1|188252|33|NZ_AP022590|CRISPRCasFinder matches to position: 192234-192266, mismatch: 0, identity: 1.0

cggcggtggagggcttttgggctcgggtggcac	CRISPR spacer
cggcggtggagggcttttgggctcgggtggcac	Protospacer
*********************************

2. spacer 3.1|188252|33|NZ_AP022590|CRISPRCasFinder matches to position: 195434-195466, mismatch: 0, identity: 1.0

cggcggtggagggcttttgggctcgggtggcac	CRISPR spacer
cggcggtggagggcttttgggctcgggtggcac	Protospacer
*********************************

3. spacer 3.2|188312|57|NZ_AP022590|CRISPRCasFinder matches to position: 192294-192350, mismatch: 0, identity: 1.0

tagtgtcggtggcacgttgaccgatggcggcactgtgacggtgagctcgggtggcct	CRISPR spacer
tagtgtcggtggcacgttgaccgatggcggcactgtgacggtgagctcgggtggcct	Protospacer
*********************************************************

4. spacer 3.3|188396|57|NZ_AP022590|CRISPRCasFinder matches to position: 192378-192434, mismatch: 0, identity: 1.0

gagctcgggtggcctgttgaccgatggtggcaccgtgacggtcaatgctggtggcgg	CRISPR spacer
gagctcgggtggcctgttgaccgatggtggcaccgtgacggtcaatgctggtggcgg	Protospacer
*********************************************************

5. spacer 3.4|188480|57|NZ_AP022590|CRISPRCasFinder matches to position: 192462-192518, mismatch: 0, identity: 1.0

cggctcgggtggggtgttgaccgatagcggcacggtgaccgtcgccagtggcggcac	CRISPR spacer
cggctcgggtggggtgttgaccgatagcggcacggtgaccgtcgccagtggcggcac	Protospacer
*********************************************************

6. spacer 3.5|188564|57|NZ_AP022590|CRISPRCasFinder matches to position: 192546-192602, mismatch: 0, identity: 1.0

gggttcgggtggcatcctgaccgacggcggcaccgtgactgtcaacgtcggtggcgt	CRISPR spacer
gggttcgggtggcatcctgaccgacggcggcaccgtgactgtcaacgtcggtggcgt	Protospacer
*********************************************************

7. spacer 5.1|194450|33|NZ_AP022590|CRISPRCasFinder matches to position: 192234-192266, mismatch: 0, identity: 1.0

cggcggtggagggcttttgggctcgggtggcac	CRISPR spacer
cggcggtggagggcttttgggctcgggtggcac	Protospacer
*********************************

8. spacer 5.1|194450|33|NZ_AP022590|CRISPRCasFinder matches to position: 195434-195466, mismatch: 0, identity: 1.0

cggcggtggagggcttttgggctcgggtggcac	CRISPR spacer
cggcggtggagggcttttgggctcgggtggcac	Protospacer
*********************************

9. spacer 5.2|194510|57|NZ_AP022590|CRISPRCasFinder matches to position: 192294-192350, mismatch: 0, identity: 1.0

tagtgtcggtggcacgttgaccgatggcggcactgtgacggtgagctcgggtggcct	CRISPR spacer
tagtgtcggtggcacgttgaccgatggcggcactgtgacggtgagctcgggtggcct	Protospacer
*********************************************************

10. spacer 5.3|194594|57|NZ_AP022590|CRISPRCasFinder matches to position: 192378-192434, mismatch: 0, identity: 1.0

gagctcgggtggcctgttgaccgatggtggcaccgtgacggtcaatgctggtggcgg	CRISPR spacer
gagctcgggtggcctgttgaccgatggtggcaccgtgacggtcaatgctggtggcgg	Protospacer
*********************************************************

11. spacer 5.4|194678|57|NZ_AP022590|CRISPRCasFinder matches to position: 192462-192518, mismatch: 0, identity: 1.0

cggctcgggtggggtgttgaccgatagcggcacggtgaccgtcgccagtggcggcac	CRISPR spacer
cggctcgggtggggtgttgaccgatagcggcacggtgaccgtcgccagtggcggcac	Protospacer
*********************************************************

12. spacer 5.5|194762|57|NZ_AP022590|CRISPRCasFinder matches to position: 192546-192602, mismatch: 0, identity: 1.0

gggttcgggtggcatcctgaccgacggcggcaccgtgactgtcaacgtcggtggcgt	CRISPR spacer
gggttcgggtggcatcctgaccgacggcggcaccgtgactgtcaacgtcggtggcgt	Protospacer
*********************************************************

13. spacer 3.4|188480|57|NZ_AP022590|CRISPRCasFinder matches to position: 184259-184315, mismatch: 1, identity: 0.982

cggctcgggtggggtgttgaccgatagcggcacggtgaccgtcgccagtggcggcac	CRISPR spacer
cggctcgggtggggtgttgaccgatagcggcacggtgaccgtcgccagtggtggcac	Protospacer
***************************************************.*****

14. spacer 5.4|194678|57|NZ_AP022590|CRISPRCasFinder matches to position: 184259-184315, mismatch: 1, identity: 0.982

cggctcgggtggggtgttgaccgatagcggcacggtgaccgtcgccagtggcggcac	CRISPR spacer
cggctcgggtggggtgttgaccgatagcggcacggtgaccgtcgccagtggtggcac	Protospacer
***************************************************.*****

15. spacer 3.5|188564|57|NZ_AP022590|CRISPRCasFinder matches to position: 184343-184399, mismatch: 2, identity: 0.965

gggttcgggtggcatcctgaccgacggcggcaccgtgactgtcaacgtcggtggcgt	CRISPR spacer
gggttcgggtggcaccgtgaccgacggcggcaccgtgactgtcaacgtcggtggcgt	Protospacer
**************.* ****************************************

16. spacer 5.5|194762|57|NZ_AP022590|CRISPRCasFinder matches to position: 184343-184399, mismatch: 2, identity: 0.965

gggttcgggtggcatcctgaccgacggcggcaccgtgactgtcaacgtcggtggcgt	CRISPR spacer
gggttcgggtggcaccgtgaccgacggcggcaccgtgactgtcaacgtcggtggcgt	Protospacer
**************.* ****************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP022590_9	9.2|2122208|22|NZ_AP022590|CRT	2122208-2122229	22	NZ_CP045217	Pantoea dispersa strain BJQ0007 plasmid unnamed1, complete sequence	39283-39304	2	0.909
NZ_AP022590_9	9.2|2122208|22|NZ_AP022590|CRT	2122208-2122229	22	NZ_CP044079	Paracoccus yeei strain FDAARGOS_643 plasmid unnamed2, complete sequence	312018-312039	2	0.909
NZ_AP022590_9	9.2|2122208|22|NZ_AP022590|CRT	2122208-2122229	22	NZ_CP031079	Paracoccus yeei strain CCUG 32053 plasmid pYEE1, complete sequence	218468-218489	2	0.909
NZ_AP022590_9	9.2|2122208|22|NZ_AP022590|CRT	2122208-2122229	22	NZ_CP016620	Microvirga ossetica strain V5/3m plasmid unnamed4, complete sequence	137024-137045	2	0.909
NZ_AP022590_9	9.3|2122256|22|NZ_AP022590|CRT	2122256-2122277	22	NZ_CP035002	Rhizobium acidisoli strain FH23 plasmid pRapFH23d, complete sequence	549486-549507	2	0.909
NZ_AP022590_9	9.4|2122304|22|NZ_AP022590|CRT	2122304-2122325	22	NZ_CP021331	Maritalea myrionectae strain HL2708#5 plasmid pHL2708X3, complete sequence	11189-11210	2	0.909
NZ_AP022590_9	9.8|2122529|22|NZ_AP022590|CRT	2122529-2122550	22	NZ_LT960615	Hartmannibacter diazotrophicus strain E19T plasmid HDIAp1, complete sequence	115591-115612	2	0.909
NZ_AP022590_1	1.1|30872|33|NZ_AP022590|CRISPRCasFinder	30872-30904	33	NZ_CP049158	Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence	318910-318942	5	0.848
NZ_AP022590_1	1.1|30872|33|NZ_AP022590|CRISPRCasFinder	30872-30904	33	NZ_CP049318	Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence	318119-318151	5	0.848
NZ_AP022590_13	13.1|6181095|33|NZ_AP022590|CRISPRCasFinder	6181095-6181127	33	NZ_CP049158	Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence	318910-318942	5	0.848
NZ_AP022590_13	13.1|6181095|33|NZ_AP022590|CRISPRCasFinder	6181095-6181127	33	NZ_CP049318	Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence	318119-318151	5	0.848
NZ_AP022590_1	1.1|30872|33|NZ_AP022590|CRISPRCasFinder	30872-30904	33	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	550191-550223	6	0.818
NZ_AP022590_13	13.1|6181095|33|NZ_AP022590|CRISPRCasFinder	6181095-6181127	33	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	550191-550223	6	0.818
NZ_AP022590_1	1.1|30872|33|NZ_AP022590|CRISPRCasFinder	30872-30904	33	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	767813-767845	7	0.788
NZ_AP022590_1	1.1|30872|33|NZ_AP022590|CRISPRCasFinder	30872-30904	33	LT559120	Nonomuraea sp. ATCC 39727 isolate nono1 genome assembly, plasmid: III	43781-43813	7	0.788
NZ_AP022590_9	9.6|2122400|34|NZ_AP022590|CRT	2122400-2122433	34	NZ_AP014707	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_3p, complete sequence	28129-28162	7	0.794
NZ_AP022590_13	13.1|6181095|33|NZ_AP022590|CRISPRCasFinder	6181095-6181127	33	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	767813-767845	7	0.788
NZ_AP022590_13	13.1|6181095|33|NZ_AP022590|CRISPRCasFinder	6181095-6181127	33	LT559120	Nonomuraea sp. ATCC 39727 isolate nono1 genome assembly, plasmid: III	43781-43813	7	0.788
NZ_AP022590_1	1.1|30872|33|NZ_AP022590|CRISPRCasFinder	30872-30904	33	NZ_CP049906	Diaphorobacter sp. HDW4B plasmid unnamed1, complete sequence	16486-16518	8	0.758
NZ_AP022590_1	1.1|30872|33|NZ_AP022590|CRISPRCasFinder	30872-30904	33	NZ_CP022991	Paraburkholderia aromaticivorans strain BN5 plasmid pBN1, complete sequence	266565-266597	8	0.758
NZ_AP022590_9	9.1|2122148|34|NZ_AP022590|CRT	2122148-2122181	34	NC_048047	Caulobacter phage CcrBL9, complete genome	253711-253744	8	0.765
NZ_AP022590_9	9.6|2122400|34|NZ_AP022590|CRT	2122400-2122433	34	NZ_CP054618	Azospirillum oryzae strain KACC 14407 plasmid unnamed4, complete sequence	19157-19190	8	0.765
NZ_AP022590_10	10.1|2214028|32|NZ_AP022590|CRISPRCasFinder	2214028-2214059	32	NC_012521	Rhodococcus opacus B4 plasmid pROB02, complete sequence	122787-122818	8	0.75
NZ_AP022590_13	13.1|6181095|33|NZ_AP022590|CRISPRCasFinder	6181095-6181127	33	NZ_CP049906	Diaphorobacter sp. HDW4B plasmid unnamed1, complete sequence	16486-16518	8	0.758
NZ_AP022590_13	13.1|6181095|33|NZ_AP022590|CRISPRCasFinder	6181095-6181127	33	NZ_CP022991	Paraburkholderia aromaticivorans strain BN5 plasmid pBN1, complete sequence	266565-266597	8	0.758
NZ_AP022590_9	9.1|2122148|34|NZ_AP022590|CRT	2122148-2122181	34	NZ_CP023068	Ensifer sojae CCBAU 05684 plasmid pSJ05684b, complete sequence	1661463-1661496	9	0.735
NZ_AP022590_9	9.1|2122148|34|NZ_AP022590|CRT	2122148-2122181	34	NZ_CP017942	Phyllobacterium zundukense strain Tri-48 plasmid unnamed3, complete sequence	369234-369267	9	0.735
NZ_AP022590_9	9.6|2122400|34|NZ_AP022590|CRT	2122400-2122433	34	NZ_CP029357	Azospirillum sp. CFH 70021 plasmid unnamed2	451311-451344	10	0.706
NZ_AP022590_9	9.6|2122400|34|NZ_AP022590|CRT	2122400-2122433	34	NZ_CP022925	Klebsiella pneumoniae strain ST307PT01 plasmid pJYC01B	24030-24063	10	0.706
NZ_AP022590_12	12.2|5466188|35|NZ_AP022590|CRISPRCasFinder	5466188-5466222	35	MH669001	Mycobacterium phage EleanorGeorge, complete genome	12514-12548	10	0.714
NZ_AP022590_9	9.6|2122400|34|NZ_AP022590|CRT	2122400-2122433	34	NZ_CP012748	Paraburkholderia caribensis MBA4 plasmid unnamed, complete sequence	1899831-1899864	11	0.676

1. spacer 9.2|2122208|22|NZ_AP022590|CRT matches to NZ_CP045217 (Pantoea dispersa strain BJQ0007 plasmid unnamed1, complete sequence) position: , mismatch: 2, identity: 0.909

ggcggcctctgcccgcgcccgt	CRISPR spacer
ggcggcctctgcccgcgtccgc	Protospacer
*****************.***.

2. spacer 9.2|2122208|22|NZ_AP022590|CRT matches to NZ_CP044079 (Paracoccus yeei strain FDAARGOS_643 plasmid unnamed2, complete sequence) position: , mismatch: 2, identity: 0.909

ggcggcctctgcccgcgcccgt	CRISPR spacer
ggcggcctttgcccgcgcccgg	Protospacer
********.************ 

3. spacer 9.2|2122208|22|NZ_AP022590|CRT matches to NZ_CP031079 (Paracoccus yeei strain CCUG 32053 plasmid pYEE1, complete sequence) position: , mismatch: 2, identity: 0.909

ggcggcctctgcccgcgcccgt	CRISPR spacer
ggcggcctttgcccgcgcccgg	Protospacer
********.************ 

4. spacer 9.2|2122208|22|NZ_AP022590|CRT matches to NZ_CP016620 (Microvirga ossetica strain V5/3m plasmid unnamed4, complete sequence) position: , mismatch: 2, identity: 0.909

ggcggcctctgcccgcgcccgt	CRISPR spacer
ggcggcgtctgcccgcgcccgg	Protospacer
****** ************** 

5. spacer 9.3|2122256|22|NZ_AP022590|CRT matches to NZ_CP035002 (Rhizobium acidisoli strain FH23 plasmid pRapFH23d, complete sequence) position: , mismatch: 2, identity: 0.909

agcggccttcgcccgccttcgc	CRISPR spacer
agcggccttcgcccgcattcgg	Protospacer
**************** **** 

6. spacer 9.4|2122304|22|NZ_AP022590|CRT matches to NZ_CP021331 (Maritalea myrionectae strain HL2708#5 plasmid pHL2708X3, complete sequence) position: , mismatch: 2, identity: 0.909

ggcggctttggcctgcttttgg	CRISPR spacer
ggcggcattggcctgcttttga	Protospacer
****** **************.

7. spacer 9.8|2122529|22|NZ_AP022590|CRT matches to NZ_LT960615 (Hartmannibacter diazotrophicus strain E19T plasmid HDIAp1, complete sequence) position: , mismatch: 2, identity: 0.909

ggcggcttcttcctgcgcccga	CRISPR spacer
ggcggcttcttcctccgcccgg	Protospacer
************** ******.

8. spacer 1.1|30872|33|NZ_AP022590|CRISPRCasFinder matches to NZ_CP049158 (Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence) position: , mismatch: 5, identity: 0.848

gccagcgtggcgatcgtgagcgcg-gcggcgcca	CRISPR spacer
gccagcgtggcgatggtgagcgcgcacgttgcc-	Protospacer
************** ********* .** .*** 

9. spacer 1.1|30872|33|NZ_AP022590|CRISPRCasFinder matches to NZ_CP049318 (Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence) position: , mismatch: 5, identity: 0.848

gccagcgtggcgatcgtgagcgcg-gcggcgcca	CRISPR spacer
gccagcgtggcgatggtgagcgcgcacgttgcc-	Protospacer
************** ********* .** .*** 

10. spacer 13.1|6181095|33|NZ_AP022590|CRISPRCasFinder matches to NZ_CP049158 (Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence) position: , mismatch: 5, identity: 0.848

gccagcgtggcgatcgtgagcgcg-gcggcgcca	CRISPR spacer
gccagcgtggcgatggtgagcgcgcacgttgcc-	Protospacer
************** ********* .** .*** 

11. spacer 13.1|6181095|33|NZ_AP022590|CRISPRCasFinder matches to NZ_CP049318 (Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence) position: , mismatch: 5, identity: 0.848

gccagcgtggcgatcgtgagcgcg-gcggcgcca	CRISPR spacer
gccagcgtggcgatggtgagcgcgcacgttgcc-	Protospacer
************** ********* .** .*** 

12. spacer 1.1|30872|33|NZ_AP022590|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 6, identity: 0.818

gccagcgtggcgatcgtgagcgcggcggcgcca--	CRISPR spacer
gccagcttggcgatcgtgaacgcggc--cgtcggc	Protospacer
****** ************.******  **.*.  

13. spacer 13.1|6181095|33|NZ_AP022590|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 6, identity: 0.818

gccagcgtggcgatcgtgagcgcggcggcgcca--	CRISPR spacer
gccagcttggcgatcgtgaacgcggc--cgtcggc	Protospacer
****** ************.******  **.*.  

14. spacer 1.1|30872|33|NZ_AP022590|CRISPRCasFinder matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 7, identity: 0.788

gccagcgtggcgatcgtgagcgcggcggcgcca	CRISPR spacer
gccgcggtggcggtcgtgagcgcggcgacggcg	Protospacer
***.  ******.**************.** *.

15. spacer 1.1|30872|33|NZ_AP022590|CRISPRCasFinder matches to LT559120 (Nonomuraea sp. ATCC 39727 isolate nono1 genome assembly, plasmid: III) position: , mismatch: 7, identity: 0.788

gccagcgtggcgatcgtgagcgcggcggcgcca	CRISPR spacer
gcgggggtggcgatcgtgcgcgcggcgccgtcg	Protospacer
** .* ************ ******** **.*.

16. spacer 9.6|2122400|34|NZ_AP022590|CRT matches to NZ_AP014707 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_3p, complete sequence) position: , mismatch: 7, identity: 0.794

cgcggcgtccgcgtgcgccttctc-----ccgcgcccgc	CRISPR spacer
cgcggcgtcggcgagcgccttctcgaggaccgcg-----	Protospacer
********* *** **********     *****     

17. spacer 13.1|6181095|33|NZ_AP022590|CRISPRCasFinder matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 7, identity: 0.788

gccagcgtggcgatcgtgagcgcggcggcgcca	CRISPR spacer
gccgcggtggcggtcgtgagcgcggcgacggcg	Protospacer
***.  ******.**************.** *.

18. spacer 13.1|6181095|33|NZ_AP022590|CRISPRCasFinder matches to LT559120 (Nonomuraea sp. ATCC 39727 isolate nono1 genome assembly, plasmid: III) position: , mismatch: 7, identity: 0.788

gccagcgtggcgatcgtgagcgcggcggcgcca	CRISPR spacer
gcgggggtggcgatcgtgcgcgcggcgccgtcg	Protospacer
** .* ************ ******** **.*.

19. spacer 1.1|30872|33|NZ_AP022590|CRISPRCasFinder matches to NZ_CP049906 (Diaphorobacter sp. HDW4B plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.758

gccagcgtggcgatcgtgagcgcgg----cggcgcca	CRISPR spacer
gacagtgtggcgctcgtgagcgcggctttcggt----	Protospacer
* ***.****** ************    ***.    

20. spacer 1.1|30872|33|NZ_AP022590|CRISPRCasFinder matches to NZ_CP022991 (Paraburkholderia aromaticivorans strain BN5 plasmid pBN1, complete sequence) position: , mismatch: 8, identity: 0.758

gccagcgtggcgatcgtgagcgcggcggcgcca	CRISPR spacer
gagcgcccggtgatcgcgagcgcggcggcgccg	Protospacer
*   ** .**.*****.***************.

21. spacer 9.1|2122148|34|NZ_AP022590|CRT matches to NC_048047 (Caulobacter phage CcrBL9, complete genome) position: , mismatch: 8, identity: 0.765

ggcggcttcggcgcgcgcccgctctaacacctgc	CRISPR spacer
cgcatcctgggcgcgcgcctgctcaaacacctgg	Protospacer
 **. *.* **********.**** ******** 

22. spacer 9.6|2122400|34|NZ_AP022590|CRT matches to NZ_CP054618 (Azospirillum oryzae strain KACC 14407 plasmid unnamed4, complete sequence) position: , mismatch: 8, identity: 0.765

cgcggcgtccgcgtgcgccttctcccgcgcccgc	CRISPR spacer
gggggtgcgcgcgtgctcctcctcccgcgcccgg	Protospacer
 * **.*. ******* ***.************ 

23. spacer 10.1|2214028|32|NZ_AP022590|CRISPRCasFinder matches to NC_012521 (Rhodococcus opacus B4 plasmid pROB02, complete sequence) position: , mismatch: 8, identity: 0.75

tgcccaaccgccccactcctcctcaggcctac	CRISPR spacer
tgcccaaccgccgcactcatcctcgagcagga	Protospacer
************ ***** *****..**  . 

24. spacer 13.1|6181095|33|NZ_AP022590|CRISPRCasFinder matches to NZ_CP049906 (Diaphorobacter sp. HDW4B plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.758

gccagcgtggcgatcgtgagcgcgg----cggcgcca	CRISPR spacer
gacagtgtggcgctcgtgagcgcggctttcggt----	Protospacer
* ***.****** ************    ***.    

25. spacer 13.1|6181095|33|NZ_AP022590|CRISPRCasFinder matches to NZ_CP022991 (Paraburkholderia aromaticivorans strain BN5 plasmid pBN1, complete sequence) position: , mismatch: 8, identity: 0.758

gccagcgtggcgatcgtgagcgcggcggcgcca	CRISPR spacer
gagcgcccggtgatcgcgagcgcggcggcgccg	Protospacer
*   ** .**.*****.***************.

26. spacer 9.1|2122148|34|NZ_AP022590|CRT matches to NZ_CP023068 (Ensifer sojae CCBAU 05684 plasmid pSJ05684b, complete sequence) position: , mismatch: 9, identity: 0.735

ggcggcttcggcgcgcgcccgctctaacacctgc	CRISPR spacer
ggcggcatcgacgcgcgcccgctccgaggcgtca	Protospacer
****** ***.*************..* .* *  

27. spacer 9.1|2122148|34|NZ_AP022590|CRT matches to NZ_CP017942 (Phyllobacterium zundukense strain Tri-48 plasmid unnamed3, complete sequence) position: , mismatch: 9, identity: 0.735

ggcggcttcggcgcgcgcccgctctaacacctgc	CRISPR spacer
ggcggcgtcggtgcgcgcccgctccacggcgtcg	Protospacer
****** ****.************.*  .* *  

28. spacer 9.6|2122400|34|NZ_AP022590|CRT matches to NZ_CP029357 (Azospirillum sp. CFH 70021 plasmid unnamed2) position: , mismatch: 10, identity: 0.706

cgcggcgtccgcgtgcgccttctcccgcgcccgc	CRISPR spacer
gatcgcctccgcgagcgccttctcccgcgcgtcg	Protospacer
 .. ** ****** **************** .  

29. spacer 9.6|2122400|34|NZ_AP022590|CRT matches to NZ_CP022925 (Klebsiella pneumoniae strain ST307PT01 plasmid pJYC01B) position: , mismatch: 10, identity: 0.706

cgcggcgtccgcgtgcgccttctcccgcgcccgc	CRISPR spacer
ggtgttttccgcctgcgccttctccagcgcctct	Protospacer
 *.* . ***** ************ *****. .

30. spacer 12.2|5466188|35|NZ_AP022590|CRISPRCasFinder matches to MH669001 (Mycobacterium phage EleanorGeorge, complete genome) position: , mismatch: 10, identity: 0.714

ggccaccgcctggtgcggctccgctgcccggcccc	CRISPR spacer
cgtcgggcactggtgcgggtccgctgcccggtcca	Protospacer
 *.*.    ********* ************.** 

31. spacer 9.6|2122400|34|NZ_AP022590|CRT matches to NZ_CP012748 (Paraburkholderia caribensis MBA4 plasmid unnamed, complete sequence) position: , mismatch: 11, identity: 0.676

cgcggcgtccgcgtgcgccttctcccgcgcccgc	CRISPR spacer
attgcgagtggcgtgcgccttctcctgcacccgc	Protospacer
  .*  . . ***************.**.*****

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	5031869 : 5089629	53	Burkholderia_virus(21.43%)	protease,holin,transposase	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NZ_AP022590|5031869:5089629|DBSCAN-SWA
CTCAGCCGGCGACTGGTCTTCGTTGTTGAGCGTAGTAGGCCGTCTCCAGTTCGACTGGTGGGATGTCGCCGCAGTATTGGTAGAGGCGGCTGTGGTTGAACCAGTGGACCCACCGGGCGGTGGCCAGTTCGACGTCGTCGATGGTGCGCCAGGGTTTGCCGGGTTTGATCAGCTCGGTCTTGTACAGGCCGTTGATTGTCTCGGCGAGCGCGTTGTCATAAGAGCTGCCGACCGCCCCGACCGAGGGCTGGATGCCAGCCTCGGCAAGCCGCTCGCTGAACCGGATCGGCGTATACTGAGACCCTCTATCCGTATGGTGGACAACATCTTTCAGATCCAGCACACCTCCTTGCTGGCGGGTCCAGATGGATTGCTCGATGGAGTCGAGGACCATCGAGGTGGTCATCGTAGCGGCGACTCGCCAGCCCAGGATCCGGCGGGCATAGGCGTCGGTGACGAACGCGACGTAAGCGAACCCCGACCACGTCGACACGTAGGTGAGGTCTGCCACCCACAGTCGGTTCGGGGTCGGCGGACCGAACCGGCGCTGGACAAGATCAGCTGGCCGGGCCTCGGTTGGGTCGGCGATCGTGGTCTTCTTGGTCTTGCCGCGCACCGCCCCGGCCAGGTCGAGTTCGGCCATCAGCCGTTCCACGGTGCAGCGGGCCACCGGGATCCCCTCGCGGTTCAGGGCCAGCCACACCTTGCGGGCACCGTAGACGCCGTAATTGGCGGTGTGAACCCGCACGATCTCGCGCTTGAGGACCTCGTCACGGCCCTGGCGGCGACTGGGCTCGCGATGGACCTGGTCGTAGAAGGTCGATGGGGCGACCGGCACACCCAGCTTGGTCAACTGTGCGCAGATCGACTCGACACCCCACCGCAGACCGTCAGGACCGTCTCGGTGGCCCTGATGCTCGGCGATGAACCGGGTGATTAGTGCGCTGGCCGGTCGAGTTCGGCCGCGAAGAAAGCCGACGCGGTCTTCAAAATCGCGTTGGCCCTTCGCAATTCGGCGACTTCCCGCCTGAGCTTCTTCAGCTCAGCGGACTCCTCGCTTGTCGTACCAGGTCGTGAGCCGGCATTAATCTGGGCCTGGCGCACCCACTTGCGCACCGTCTCGGCCGTGCCAACCCCGAGCAGCCGGGCGACCTCACAGATCGCCGCCCACTCCGAATCGTGCTGATCACTGATCTCGACGACCATCCGCACAGCCCGCTCCCGCAGCTCTGGGGGGTAACGTCTCGACGTCCTCTCTGACATGACTCCAACCTTCCCAAGAAGTGGAGTCTGAACCATCCCGCGTTTGATGCGCACCTCCTTCCTTGGGAAGGTGCATGTCATGCCGAGCAAGTACGACCCGCAGACGCGGGCCAAGGCGGTCCGTCTGGTGTTGGAGCACCGTGCTGACTACCCAAGTGAGTGGGCGGCGATCACGGCGGTGTCCAAGCGGTTGGGGATGACGGCCGAGACGCTGCGTAGTTGGATCCGTCAGCAGCAGGTCGACGACGGTGATCGTGACGGTGTCTCCTCGGCGGCGGCCGCTGAGATCCGCGCCCTCAAGCGGCGCAACGCCGAGCTCGAGCAGACGATCGAAATCCTCAAGGCGGCAACGTCTTTCTTCGTGCGGGAGAGCGACCCGCGCAACCGCCGCTGACCAGTTCGGTCTGCGAGTTCATCGCCAAACACAGGCACCGCTTCGGGGTCGCTCCGATCTGCCGCGTGCTCACCGAGCACGGTGTGCCGATCGCCCCACGCACCTTCTACGCCTGGGTCAAGCGGGCACCGTCGAAGCGAGCCCTGTGGGACGCCACCATCAGCGAGGTCTTGGCCGGCTACTACGAACCCGATGAGCACGGCCGGCGCAAGCCCGAGTCGCTGTACGGGTCGGTGAAGATGTGGGCACATCTGCAGCGCAAAGGCATCCCGGTGGCGAAGTCCACGGTGGAACGCCTGATGCGCCGAAACGGGTGGCAGGGCGTACGCCGCCAGAAGGCCGTGCGCACCACGATCGCCGACCCGGCGGCGGTGAGGCCACCGGATCTGGTGGATCGCCAGTTCGGGGTGGGCGCACCCAACCAGCTGCTCGTTGCGGACTTCACCTACGTCAAGCTCGTCACGGGGGTGTTCGTCTACGTCGCATTCGTCATCGACGCCTACGCCGGGGCGATCGTGGGATGGGAGGCCTGCGCCTCCAAGCAGACCCAGTTCGTCGAATCGGCGATCCGTCAGGCCGTCGCATTGCGGTCGCGTCAGGGTCACCCGATCGAGGACGCCATCCACCACAGCGACGCAGGATCGCAGTACACCAGCGTGAGATTCGGTGAAACACTTGCCCTTTCGGGCATCCGACCCTCGGTCGGCAGTGTCGGCGATGCCTATGACAATGCTCTGGCCGAGACCACGATCGGACTCTACAAGACTGAGTGCATCCGGCCTGATTCCCCGTTCCGTCGCGGGCCGCTCACCACGGTCGGTGACGTCGAGTACATCACCGCCGACTACGTCGCCTGGTACAACCAGCAGCGCCTCATGCACCGCCTCGGCCGAGTCCCACCCGCCGAAGCCGAAGCCCAGTACTATTCCCAACACGTGACCGACCAACCGGCCGGCTCACAGAACCCCGAGGGTGCATGAAACCCGGGATGCTTCAGTCTCCGGACATTCCGGGGCGGTTCACAGCCGCCAGCTTGGCGGTGTCGGCGGGTGGGAACGTTCTTGCGCTCGCGAGGATGCTCGGTCACGAAGACCCGAGCCTTACACTGCGGACATACGCTGACCTGTTTGACTCCGACCTGGATGCACTGGCTGATGTGCTGGACCAGCACCGCACGGCGGCGCTGGAACCCTCAACTGCCAACAACGACAGTGAAACTGATGGGAAAAACGTACCGAGTACGCTGCCGCAAACTGCCTAATGTCTTCCGTGAGCCTGTTACCAGGCTCTACGAGTCGGGGTGGCGGGATTCGAACCCACGGCCTCTTCGTCCCGAACGAAGCGCGCTACCAAGCTGCGCCACACCCCGCTTGAAGCTTCGACAGCCTATCGCACCGGGGCATGGGGTGGCCAAACCGCGGTGCGCCGGGTCACTTCCAGGAGCAGGATCGCTCGAACTCCACCAGCGCCTCGGCCGGGCCGGCCGGATCGAGCCCCTGCGCGGCGACCCACTCGTCGCTGAAGTAGGTGTCCCGGTAGCGGTCGCCGCTGTCGGCGAGCAGCGTGACCACCGAGCCGCTGCGGCCCTCGGCGACCATCTCGGCGAGCAGGCCGAAAGCGCCCCACAGGTTGGTGCCCGTCGACGGCCCCACCCGCCGTCCCAGCACCGCGCTGACATGCCGGGCGGCCGCGATCGACGCCGCGTCCGGCACCGCCACCATCCGGTCGACCACGCCGGGCAGGAACGACGGCTCCACCCGCGGCCGGCCGATGCCCTCGATGCGCGACGAGGTGGGCATCACGATGTCGTCGCGGTCCTCGGCGTAGGCGGGGAAGAACGCGGAGTTCTCCGGGTCGACGACGCATAACCGGGTGGCGTGCCGCCGATAGCGGATGTAGCGCCCGATCGTGGCGCTGGTTCCGCCGGTGCCCGCCCCGACCACGATCCATTCCGGGACGGGGTGTTCCTCGTCGCCCATCTGCTCGAAGATCGACTCGGCGATGTTGTTGTTGCCCCGCCAGTCGGTCGCTCGTTCGGCGTTGGTGAACTGGTCCAGGTAGTGCCCCCCGGTTTCGCGGGCGACCCGCTCGGCCTCGGCGTAGACCTCGCTGGAGCTTTGCACGAAATGGCAACGGCCGCCGTGGGCTTCGATCAGCGCCACCTTCGACGTGCTCGTCGCCGCCGGCATCACGGCGACGAACGGCAGGCCCAGCAGGGCCGCGAAATAGGCCTCCGACACCGCCGTCGAACCCGACGACGCCTCGACCACCGTCGTGCCCTCGTCGATCCAGCCGTTGCACAGCGCGTAGAGGAACAACGACCGGGCCAACCGGTGTTTGAGACTGCCGGTGATGTGCGTGGTCTCGTCCTTGAGGTACAGCGCGACCTGAGCGTCGGGGCCGCCCGCGCACCACGCCGCGGGCAGCGGATAGCGAAGCAGATGCGTGTCGGCGCTACGGCGGGCGTCGGCCTGAATCAGCCGGATCGCGTTGTCTGTCCAGCACCGTGAGCGGCTGCGCACCGCAATCCGGGTCTGGCCGGTCAACGCACCGAAGCTGTTGGCTGCGAACGGCTCAGGTCACTGGCCGCGTCACGGTCGCCCATCGGGGTCGCGATCAAGGTCAACAGGGTCGCCTCCGGCCGGCAGCAGAATCGCACCGGCGCGAACGGCGAGGTTCCCATCCCGGCGGAGACATGCAACCGCATGTGCGCGCCCCAGCGGGACGGCCCCTTGGCGCGAGAGCGGTCCAGCCCGCAGTTGGTGACCAGTGCGCCGTAGAACGGCAGGCACACCTGACCGCCGTGGGTGTGACCGGCCATCACCAGCTGATAGCCGTCGGCGGCGAAGCGGTCCAGCACCCGGGGCTCGGGCGAATGTGTCAGTCCCAGCCGCAGATTCGCCGCCGGGCTCGCCGGGCCCGCGATGGTTTCGTAGCGGTCCCGGTCGATGTGCGGGTCGTCCACGCCCGCGGCGGCGACGTGCAGGCCCGCCACCTCGAACTCGCGCCGGGTGTGGGTGAGGTCGAGCCAGCCGCGCTCGGTGAACGCCGCCCGCAGGTCCTGCCAGGGCAGCGGCTCGCCGCGGACCCGGTGCGACGGGTTGGTCACGTAGTTCAGCGGGTTCTTCAGGCGCGGCGCGAAGTAGTCGTTGCTACCGAACACGAACACACCCGGCCGCGACAGCAGATCGCCCAGGGCCTGGATGACCGACGGCACGGCCTTCGGGTGGGCCAGGTTGTCGCCGGTGTTGACCACCAGGTCCGGTTCCCAGCCGGCCAACTCGCGCAGCCACGCCTGTTTGCGGCGTTGGCCGGGCGTCATGTGGAGATCGCTGATATGCAGCACGCGCAGCGGTGTCGAGCCCGGGGTCAACACGGGCATGGTGATCTCGCGCAGGACGAACGCGTTCCGCTCGATGACCGCGGCGTAACCGAGGCCGGCGACGCTCGTACCGAGCGCGGCGGCGCCGGCACGTATCAGGACGGGCAAAACATCAGCCATGCTGGCAGCCTACTGCCGGCCGCGGACCGGCAGCGTATCTCTTGGATTACGGCGTCTACGGAGGTGGCTGACCGGGCGCGGGCGGCGGGGGCGCCAGCAGCGGAATCGTGATCGGCGGCAGCCCTGGAATCTCGACGACCTGCGAGCCGACTGGCGGCGGTGCCCCTTCCGGTGGCGGCGGCGGCGCGGGCGGGATGCCGTTACTGACCTGGATGGTGATGATCGACCCCGGAATCGTTGCGCCGCTGGGGGTTGTCCCGACCACCTCGCCCTGCTTTGCGCTGCTGTTGACGAAGCTGTTCTGGTCGGCGACCTGGAAGCCCGCCTCCTTGATGCGCTGCCGTGCCGCGTCGATGTCCAGGCCGGCCACGCTGGGCACCCTGGACCCGGGTGCCCCGTCGACATAGCGAGGGTCGGTGGGCGGCAACTGCACCGGCCCGAAATTGGTGGCGATCGGCTTCATCGCGGTAAACCACGTGCGCGCGGGTTCATTACCGCCGTACAGGTCGCCCTCGCCGCAGTGGCGCAGCGGAGAAGAGCACAGATCGGTGGGGTTGGGGGAGTCGTCGTAGATGTAGTTGGCCGCCGCGTAATGGTTGGTGAAGCCCACGAAGCCCGACGAGCGGTGCGCCTCGGTGGTGCCCGTCTTGCCGGACACCGGCAGGTCCCAGCCCGCCGCGCTGGCCGAACCCGCCGCCGTGCCGCCGCCCAACGCGTCCTTGCTCATCGCGTTGGCCAGCGTGTTCGCCAGACCGTCGGGCACCACCTGGTCGCAGGTCTCGGTGGTCACGGCGACCTCGTTGCCCTTGCGGTCGACCAGCTTGTCGATCGGGTTGGGTGGGCACCAGGTGCCCCCCGAGGCGAGGGTGGCCGCGACGTTGGACAGCTCCAGCGCGTTCACCTCGATCGGGCCCAACGTGAACGAGCCGATGTTCTGCCGTTTGACGAAGTCGGCCAGGCTCTCGTTGCTGTCGGGGTTGTAGTCGCGGGCCGTGCCGGGGTCGGCGTAGGACCGCAGCCCGAGCTTGATCGCCATGTCGACCGTGCGTGTCACGCCGACCTGTTGGATCAGCTTGGCGAACGCGGTGTTTGGCGAGGTGGCCAACGCGTCGGTGACGTTCATCGACCCGCGGTAATTACCGGCGTTGACCACGCACCAGTTGTCCTTCGGGCAGCCCTTGGCCCCGCCGCTACCCATGCCCTTCGCCTGGAAGCGGCCGGGCACCTCGAGGATGGCGTTGGTGCCCATCCCCATGTCCAGGGCCGCGGCCGTGGTGAAGATCTTGAAGACGGACCCCGCACCGTCGCCGACCAGCGAGAACGGCTGTGGGCGCATGGTTTGACCGGCGTCGACGTCGAGCCCGTAGGTGCGGTTGCTGGCCATCGCCATCACCTTGTGCGACGTCTTGCCGGGCTGGATCACGCTCATCACGCTCGAGATCCCCGGGAGCGTCGGGCTGGCGAATTTGTCGATGGCCGTCTTGACCGGGATCTGCACGTCGGGGTCCAGCGTCGTCTTGATCAGGTAGCCGCCCCGGGCCACCTGTTCCTTGCTGATCCCGGCCCGGGAGAGGTACTCCTGGACGTAGTCGCAGAAGAAGGCGCGATCGCCCGCCGCGATGCAGCCGCGGGGGAGCTCGTTGGGCTGCGGCAGGATTCCCAGGGGCGTGGCCTTGGCCGCGCGCAGCGCATCGGCCTCCTGCGGGATGTTCTCGATCATGGTGTCCAGCACCAAGTTTCGCCGCGCCAGCGCACCGTCGGGATTGATGTACGGGTTGAGCGCACTGGTCGACTGCACCATGCCCGCCAGCAGCGCCGCCTGCTGCCAGTTCAGGTCGGACGCGTTGATGCCGAAGTAGGTTTGGGCGGCGTCCTGCACGCCGAACGACCCGTTGCCGAACGAGACCAGGTTCAGATACCGGGTCAGGATTTCGGGCTTGGTGAAGGTTTTGTCCAGCGTCAGCGCCATGCGGATCTCGCGCAGCTTGCGGGCCGGGGTGGTCTCCACCGCCGCGCGCTTCTCGGCGTCGGTTTTCGCGGTCACCAGCAGTTGGTAGTTCTTGATGTACTGCTGCTCGATGGTCGAGCCACCGCGGGTGTCCACGTCACCGCGCGCGTAGCCGGCCAGCCCGGTCAGGGTGCCTTTCCAGTCGACCCCGTTGTGTTCGGCGAACCGCTTGTCCTCGATGGACACGATCGCCAGCTTCATCGTGTTGGCGATCTTGTCGCTGGGCACCTCGAAGCGGCGCTGCGAATACAGCCAGGCGATGGTGTTGCCCTTGGCGTCGACCATCGTCGACACGGCCGGCACCTCGCCCTCGAGCAGCTGGGCCGAGCCGTTGGTGACCACTTCCGAGGCCCGATTGGACACCAGGCCTATTCCGCCGGCGAAGGGAAACAGCAGGGCTGTGGCGACCACACTGGCCAACAAACAGAGCCCCGCAAGCTTGAGGATCGTGAGCGCGGCCGGGGGGCGGTCTGACATGGCTACTACAGTAGCGGCCCTCAGTCACGTCGCCACGCTGCGCGTTCGCTCAAAAATTGCGTCGTTTCGCGATCGGGGGCGGCCCGCCCGAATTTGCAGTCGCGTCACAGGTCAGAAGTGCAGCGGAGTGTGCAAGATCACTTTTCGGCTATCGTCCGGTACGAGACGGCACGCCCGTCCCAAAAAAAGCGTTATCGGACTGTTGCGCAATTGGCACCTGACCACCTAACTTAGACACACGGTGAGATTCAGGTAACACCGATGTACATAGTGTGGCGTAGATCGCTAGGTGAGGATCTGCACCCCAGGAGGGCGGCCGTGACGGGCGGCCGGTAGGGAAGGGAACAGTTCGTGTCACCAATACGGCCGGCGGCGCGCAGGACAAACATTGCAGCCGCACAAGGGATACTTCGCAGTGTCGATGCCGAAGAACGGATCGCTTGGGTCTCCAGGGCGCTATGCCGGACCACCGATCCCGACGAACTGTTTGTCCGCGGAGCGGCCCAGCGTAAGGCGGCAGTGATCTGCCGGCATTGCCCGGTGATGCAGGAATGCGGAGCAGACGCGCTGGACAACAAGGTCGAGTTCGGGGTGTGGGGCGGCATGACCGAGCGGCAGCGCCGCGCCCTGCTCAAGCAGCACCCCGAGGTGGTGTCCTGGGCGGACTTCTTCGACAAGAAGCGTGGCCGCAGCGTCAGCTGATCCAGCGGTTCGACCGGGCCCCTGGCACAAGGGCCCGTCGCCTCGTCACCGAGGTGGCCAGACGGGCCAGTTCCTCAGCGGGCCGTTGCCCGGCCCGCCTCGTCACCGAGGTGGCCAGACGGGCCGGTTCCTCAGCGGGCCGTTGCCCGGCCCGCCTCGTCACCGACCGAAGTGATTTGATCGGCGAGCGCCCGCAGCGCCTCCAAGTCCGAGACATCGAACGGCAGCGACGGAACGCCGATGACCGGCACATGCGGATGGGCTCCGGTGAACCGGGAAAGCAATCTGATCTCCCGCTTGGCGGTCTGCGCACGGTCGGCGTGAATCTTCAACACCGCCGAGGCCAGCGACGCCGCTTCGGAGTCGGCATCATGATCCAGCATTTCGCTGCCGTCGATCGCGCGCTCGGCCGGCAGGGAGCACAGCGGCGGATGGGTGCGGTTCAGAACCAGCCCCGCGAGCGGCATCCCCTCCTGCGACAGCCGGTCGACGAAAAAGGCCGCCTCGCGCAGCGCGTCGGGCTCGGCCGCCGACACCACAACGAACTGCGTCCCACGCCTTTTCAGCAGCGCATAGGTGCGATCGGCTTTTTCGCGAAACCCGCCGAAGGTGGCGTCCAGCGACTGCACGAACGCTGCGGCATCGCCGAGCATCTGTGAACCCAGGATCGTGGACATCGCCTTCATCGCCAAACCCATTGCGCCGGTGACCAACCGGCCGATGCCCCGGCCCGGCGCCAGCAATAGCCGCCACAATCGGCTGTCCATGAAGCTGCCCAGCCGCTTCGGCGCGTCCAAAAAGTCCAGTGCGTTGCGCGACGGCGGGGTGTCGACGACCACCAGGTCCCAGCGATCCTCGGCCAGCAGCTGGCCCAGCTTCTCCATCGCCATGTACTCCTGCGTACCGGCGAGTGAACTGGCGACGGTCTGATAGAACTGGTTGTCCAGAATCGCTTGTGCGCGACCGGGTCCCGAGTACTGGACCACCATCTCGTCGAAGGTGCGGCGCATGTCGAGCATCATCGCGTGCAGCTCGCCGGGAACCTCCGCGGCCAGCGGGACCCGTTGCGGCGTGTTACCGAGGTCGCTGACGCCCAGTGCCTGGGCCAGCCGCTTGGCCGGGTCGATGGTCAACACGCAGACATTGCGCCCGTATTCGGCGGCGCGCAGCGCGATCGCGGCCGCGGTAGTGGTCTTGCCCACCCCGCCCGCGCCGCAGCACACCACCACACGATTGGTTGTGTCGGCCAGGATCGCGGCCATATCAAGCGGTGTGGGCGTGGTGCTCATCGAACCCCCTGCTGGGCAAGTGATTCCGACAGCTCATAGAGGCTGCCGAGGTCGACCCCGTCGGAAATCGCTGGTAGTTCCAGTCGCGACACCTTCAGCGCATCGAGCTGTTGGGCGATATCGGCGCGCGTGGCGACGACCGTCGCATGCTCGATGGTCTCCGTCAGCAGGCCCGCGAAGTCCTTGTCGTTCAGGGTGATTCCGGACTTTTCCAGTCCGGCTCGCACCGAATCCGCGTCGACGTCTCCCTCCGCGGCCTTCGCCAGATCGGCCGGCTGCAGGTACGAGGGAATGTTGCGGTTGACGATCACACTGCCGATCGGCAGCTGCATCTCGGCAAGCTCCTCGATCGCTTCCAGCGTTTCCTGGACCGGCAACGCCTCGAGCAGGGTGACCAAGTGAATGGCCGTCTGCTCGGAATGCAGCAGCTTCACCACGCCGTCGGCCTGCGAATGCACCGGGCCGCCCTTGGCCAGATCGGACACGGCTTTGGTGACATCGAGAAAACGCGCGATCCGCCCGGTGGGCGGGGCGTCCACCACGATCGCGTCATAGACCGGAAGCCGATTCTTGTCGACGCGGATCACCGTCTCCTTGATCTTGCCGGTCAGCAGCACGTCACGAAGACCCGGCGCGATCGTCGTCGCGAACTCGATCGCGCCGATCCGGCGCATCGCCCGGCCCGCGATGCCCAGGTTGTAGAACATGTCGAGGTATTCCAGGAAGGCGGCCTCGATGTCGATCGCCAGGGCATTGACCTGACCGCCGCGTTCGGCGGTCGCGATCTTCACCTCCTGATACGGCAGGGGGGGCACATCGAAGAGTTGCGCAATCCCTTGGCGGCCCTCGACTTCCACGAGCAAGACCTTGCGGCCCCCGGCGGCCAGGGTCAGGGCCAGCGCGGCCGCGATGGTCGACTTCCCCGTTCCGCCTTTGCCGGTCACAATATGTAAACGGGCCTTCGTCAAGCGCGCCGGCCAGCCGACGGCAGCTCCGCCGCTCGATGTGGTTGCCACCTTCGCATGCTAGCCCGACCGGGACTCGGGCTGGCCGGAGCGGTTCACCTGCGAGCGATAAGCTCGCGGCATGAGCCAACCGACCGCATGGGAGTACGTCACGGTCCCGCTGCTGACGCATGCCACCAAACAGATCCTCGACCAATGGGGCGCCGACGGCTGGGAGCTGGTGTCCGTGCTGCAGGGTCCGACCGGCGAGCAGCACGTCGCGTATCTGAAGCGCCCCAAGTAAGGGGTCGGGTCCGATGAGTGCTTCGGCCCGGCTCGGGCAGCTCGGCCTCGCGCTTCCGGAGGTGGTTGCGCCGCTGGCCGCCTATGTGCCGGCGGTGCGCACCGGCAATCTGGTCTACACCGCGGGCCAGCTCCCGATGGAGGCCGGAAAGCTGTTGGCTACCGGCAAGGTCGGGGCCGACGTCAGCCCGGACCAGGGCAAGGCGATGGCGCGGACCTGCGCGCTCAACGCGTTGGCTGCCGTCAACTCGCTGGTCGGTATCGACGCGGTGACGCGGGTGGTGAAGGTCGTCGGGTTCGTCGCGTCGGCGCCCGGTTTCAACGGTCAGCCAGGAGTCATCAACGGGGCCTCCGAGCTGTTCGCCGAGGTGTTCGGCGAGCAGGGCGCGCACGCGCGTTCGGCGGTCGGGGTTTCCGAGCTGCCACTGGATGCGCCGGTGGAAGTGGAGCTGATCGTCGAGGTCGGCTGACGCCCGTGACCCAGGCCGCCGAGCCGCTGACCCATCCCGCATACGCCAAGTTGCGGGCGGTCACCGAGACCGCGTCGGTCCTGTTGGCCGATAACCCCGGATTGCTGACGCTGGAGGGCACCAACACCTGGGTGTTGCGCGGCCCGCGCAGCGACGAGCTGGTCATCGTGGACCCCGGACCCGACGACGACGAGCACATCGCGCGGATCGCCGCGCTGGGCCGTATTGCCCTGGTCCTGATCAGCCACCGGCACAGCGATCACACCGACGGCATCGACAAGCTGGTCGAGCTGACCGGCGCGACCGTCCGCTCGGCGGGCAGTGGTTTTCTGCGCGGCCTCGGCGGTGAGCTGACCGACGGCGAGGTGATCCATGCCGCGGGCCTCGAGATCAAGGTCATGGCCACCCCAGGGCACACCGCCGACTCGCTGTCCTTCCTGCTCGACGATGCCGTGTTGACCGCCGATACTGTGCTGGGCCGCGGCACGGCCGTCCTCGACAAGGAGGACGGCAGCCTGACCGACTACCTGGAATCGTTGCGGCGGCTGCGCGGCCTGGGCCGGCGGACGGTGTTGCCCGGGCACGGCCCGGACCTGCCCGATCTGGAAAGCGTCGCGCAGGGCTATCTCGCGCACCGGCGGGAGCGCCTGGGCCAGGTGCGTTCGGCGTTACGCGAGCTGGGGGAGGACGCCGGCGCGCGCCGCATCGTTGAACACGTCTATGTCGATGTCGACGAGAAGCTCTGGGATGCCGCCGAGTGGTCGGTGCAGGTGCAGCTGAATCACCTGCGCTCATCGCCGGCGTAACTCTGGTCGCGCGGGCCGCTCCTGCCCCAAGAGTCCCGGCTCGGGAGACGCATGGTCCTTCTGAAATGCGCTAACGCCGGCGCTAGCACGTCGTGAAGTCGCCTATTGGTTCCCTGACGGTGCCCATGTGACAGGTGTGGCACGGGGCTAACCAGTTGACCGCCCGTGCTTCGCGCGCGCTTGAGCGGATTGCTCGACTCCTCTTCGGTCCGCTACGCGGCCCGCATCGTCGTCAAGCTACCTCGCTCGGCGGGCCAGCCGCTCGGAGTCCGAGATCAGCACGCTCTTGCCCTCCAGGCGGATCCAGCCGCGGTGGGCGAAGTCGGCCAACGCCTTGTTCACCGTCTCCCGGGACGCCCCGACCAGCTGCGCGATTTCTTCCTGCGTCAGGTCGTGGGTGACCCGCATCGCGCCGCCCTCCTGGGTGCCGAACCGCTGCGCAAGCTGCAGCAGCTGCTTGGCCACCCGGCCGGGCACGTCGGTGAAGATGAGGTCGGCCAAGTTGTTGTTGGTGCGGCGCAGGCGTCGGGCCAGCACCCGCAACAGCTGCTCGGCGATCTCGGGACGATCGGCGATCCAGGCCCGTAGCGCGTCGCGGTCCATCGACACCGCGCGCACCTCGGTGATGGTGGTGGCGCTCGACGTCCGCGGGCCCGGGTCGAAGATCGACAATTCGCCGAACATGTCCGACGGGCCCATGATCGTCAGCAGGTTCTCGCGTCCATCGGGCGAACGGCGACCGATCTTCACCTTCCCCGAGACGATGATGTACAGCCGATCGCCGGGTTCACCCTCGGCGAAGACCGTGTGTCCACGGGGGAAGTCGACGGGTTGCAGCTGCTTGGTCAGCGCTGTGACTGCGCCGGGTTCAACCCCTTGGAAGATTCCTGCCCTTGCCAGGATCTCGTCCACGTTGCCTCTTCAACTTTCCCAGAAAAATTAGTGTGATACGGGCAGGCTAACCCCTTGCTCGCGTGACGAGTCTAGAGGTACGCCAGTGTGTCTAACGTGCCAACGCTACACACGATTGGCGTGTCGAGGTGCCTTAAACTGCGGATTGACGTGCGAATGGCCGTGTATCCGGGTTGGCAATGTCAGCTCGTCGCGGTCAACGAAGCCGATCGCAAACGACGGCGCGGCGTGACGCGGCCCGCCGCCGCGCCCGTTCGCCGGGGCCTCGGCCAGCTGCTGAATCTCGCGCCGATGCAGGTATTCCAGCGCCTCCGGCATGCCTTCGGACGCCAGCGTGTGCATGTCCACACCGCCGGCACGTTCGAGGAACTCATCGACGTCGGCCACCGCCAAGGTGTCCGGGGCCAGCTCGGACTCGATCCGCCCAAGACCCAGCGCCGCCAGCATCAGCAGCGCCGGAACACCGGCCACCAGCAACCACGACACCAGAAGAGTAAACATGGCCTTGAATCAACACCGGGTCTCAGCGAGATCACGAAATCAGTACTCTGTCGTAGGTGACAGCGGCTAAGTCGTCCGGGCGTTCGAAATCGACTCCGGCCCCGCCCGGCGGCGGTGATGCCCGGCGCTGGTCCGAAGAAACCCGAGTCGGCTTGGTGCGACGGGCGCGGCGGATGAATCGTGCACTGGCACAGGCGTTTCCGGACGCACACTGCGAGCTGGACTTCACCACGCCGCTGGAACTGACCGTCGCCACGATCCTTTCGGCGCAGAGCACCGACAAGAGGGTCAATCTGACGACGCCGGCACTGTTCAAGCGGTATCCGTCGGCGCTGGATTACGCGCAGGCCAACCGCGACGAGCTGGAAAACCTCATCCGTCCGACCGGATTTTTCCGCAATAAGGCGTCCTCGCTGATCGGCCTGGGGCAGGCCCTCGTCGAACGGTTCGACGGCGAGGTGCCGTCGACCATGGCCGAACTGGTCACGCTGCCCGGAGTGGGACGCAAGACGGCCAACGTCATCCTGGGCAACGCGTTCGGGATCCCCGGCATCACCGTCGACACTCACTTCGCGCGGCTGGTGCACAGGTGGCGTTGGACCGCGGACAAGGATCCGGTCAAGATCGAGCACTCCGTCGGTGAGCTCATCGAACGCGGGGAGTGGACCATGTTGAGCCACCGGGTGATCTTCCACGGCCGCCGGGTGTGCCACGCGCGCAAACCGGCTTGCGGTGTCTGCCTGATCGCCAAGGACTGCCCCTCCTTCGGCCTGGGCCCCACCGAAGCGGCGCTGGCCGCGCCGCTGGTGAAGGGCCCGGAAACCGAGCACCTGCTCGCCCTGGCCGGCCTGTAAGCCAGCCCGCGACCGACGCGCACAGGGACCGCAATGCCGACGCTGACCCGGAAGGCTCGGTGGCACATTGCGATTCTGGCGGTGGTGGCGACGCTGATCGCGGCGCTGGTCGCCCAGCTGCGCGATGACTCAAGCACCACGGGGTCGCCCGCGAGCGGCCGGCCGGCGGCCGGCCGGGACCACCGCGACGCCGACACGCCCGCCGCGTTGGCGGGTCCGCGGCAACGCGCCAACCTGCCGCCGTGCCCTGGCGCCGGAAGCGGTCCGGGCCCCGAGGCGCTGCGCGGTGTGACGGCGGATTGCGCCGCCGACGGTTCGGTTGTCGACGTCGCCCGCGCGGTGGCCGGGCGCCGGGTCGTCCTCAACCTGTGGGCGTATTGGTGCGCGCCGTGCGCCGCCGAACTGCCCGCCATGGCCGAGTATCAACGTCGGGCCGGTTCGGACGTGACGGTGGTGACGGTGCATCAAGACGAGAACGAGACGGCCGCCCTGCTGCGGCTGGCCGAGCTCGGCGTGCGCCTGCCGACCCTGCAGGACGGTCGTCGCCGGGTCGCGGCCGCGCTGCGGGTGGCAAATGTGATGCCCGCGACGGTGGTTCTCCGGCCGGACGGTAGCGTTGCCCAGACGCTGCCACGAGCTTTCAACACTGCCGATGAGATCGCGGCTGCGATCGGCAACGACAGGGGATAAGCGGAAAAATTGAACCGACTGGAGGGGCCGTGAGTGCTGGGGGTTCACCCCTGCGGAATGGGGACCCCGCCCCCGCGCGCGGGACCGTTCCGCTGAGGCCTGACGCCAGCCCACCCTGGCTGCGTCCGCTGGTCGACAACGTCGATGACGTTCCCGACGCGGCCCGGCGCCGCCTGCCGGCCGACGTGCTGGCGATGATCACCGGCACGGCCGCATCGGCGGTCACGACGCTGCGCGGCGGCGGCCGCGAAGCCGCCGTCCTGGTGCTGTTCTCCGGTCCGCAGTCCGGGCCACCCGATGGCGGTATCCCCAACGACGCCGACCTGCTGGTCACTGTGCGGGCGTCGACCCTTCGCCACCACGCCGGTCAGGCGGCGTTTCCCGGCGGCGCCTCCGATCCCACCGACGACGGACCGGTGGGCACCGCGCTGCGCGAAGCCCGCGAGGAAACCGGGATCGACGTCAGCAGGCTGCATCCGCTGGCCACGATGGAGCGGATGTTCATCGCGCCGTCGCAGTTTCACGTCGTCCCGGTGCTGGCCTACTCGCCGGATCCCGGCCCGGTGGCCGTCGTCAATGAGGCCGAAACGGCGATCGTGGCCCGAGTTCCGGTGCGCGCCTTCATCAACCCGGCCAACCGGCTGATGGTCTACCGCGGCGACCTTGGGCGCCGGTGGGCCGGCCCGGCGTTTCTGCTCAACGAGATGCTGGTCTGGGGATTCACTGGCCAGGTGATCTCCGCGCTGCTCGACGTCGCCGGCTGGGCCCAGCCGTGGGACACCACCGACGAGCGGGAATTGGACGCGGCGATGGCGCTGGTCGGCGAAGGCGGGTCTCGATGAATTCCATGACCCCGTCGCAGTGGCTGGATGTCGCCGTCCTGGCGGTCGCCTTCATCGCGGCGATCTCGGGCTGGCGCTCGGGCGCGCTGGGCTCGTTGCTGTCGTTCGTCGGCGTGCTGCTCGGCGCGATCGCCGGGGTGCTGCTGGCACCCCACCTGGTCAGCCACATCGCCGCGCCGCGCGCGAAATTGTTTGCCGCACTGTTCTTGATCCTCGCGCTGGTCGTCATCGGCGAGGTCGCCGGTGTGGTGCTGGGACGCGCCGTCCGCGGCGCGATCCGCAGCCGTTCCATCCGGACGGTCGACTCTGTCATCGGGGTGGCGGTCCAGCTGGTCGTGGTGCTTACCGCGGCGTGGCTGTTGGCGACGCCGCTGACCCAGTCCAAGGACCAGCCCGAACTTGCCGCCGCGGTCCGCGGTTCGCGAGTGTTGGCCCAGGTCAACGAGCTGGCGCCGCCCTGGCTCAAGACGGTGCCCAAGCGACTTTCCGCGCTGCTGAACACCTCCGGTCTGCCCGCGGTGCTGGAGCCGTTCAGCCGCACCCCGGTCATTCCGGTCGCCTCTCCCGATCCCGAGCTGGCCGCCAATCCGGTGGTGCAGTCCACCGCGCCCAGTGTGGTCAAGGTCCGCAGCCTGGCCCCCAGCTGCCAGAAAGTGTTGGAGGGCAGCGGATTCGTGATCGCACCGGACCGGGTGATGACCAATGCGCACGTGGTGGCCGGTTCCAACAGTGTGCAGATCTACGCCAGCGGCAATCCCCTCGACGCCACCGTGGTGTCCTACGATCCGGCGGTCGACATCGCGATCCTGGCCGTCCCCAACTTGCCTCCGCCCCCTTTGACTTTTGCCCAGGCCGACGCGAAAACCGGTGCGAGCGTTGTGGTTCTGGGTTATCCGGGCGGCGGGAACTTCACCGCGACCCCGGCCAGGATCCGCGAACTCATCATGAACCATCCCGCGTTTGATGCGCACCTCCTTCCTTGGGAAGGTGCATGTCATGCCGAGCAAGTACGACCCGCAGACGCGGGCCAAGGCGGTCCGTCTGGTGTTGGAGCACCGTGCTGACTACCCAAGTGAGTGGGCGGCGATCACGGCGGTGTCCAAGCGGTTGGGGATGACGGCCGAGACGCTGCGTAGTTGGATCCGTCAGCAGCAGGTCGACGACGGTGATCGTGACGGTGTCTCCTCGGCGGCGGCCGCTGAGATCCGCGCCCTCAAGCGGCGCAACGCCGAGCTCGAGCAGACGATCGAAATCCTCAAGGCGGCAACGTCTTTCTTCGTGCGGGAGAGCGACCCGCGCAACCGCCGCTGACCAGTTCGGTCTGCGAGTTCATCGCCAAACACAGGCACCGCTTCGGGGTCGCTCCGATCTGCCGCGTGCTCACCGAGCACGGTGTGCCGATCGCCCCACGCACCTTCTACGCCTGGGTCAAGCGGGCACCGTCGAAGCGAGCCCTGTGGGACGCCACCATCAGCGAGGTCTTGGCCGGCTACTACGAACCCGATGAGCACGGCCGGCGCAAGCCCGAGTCGCTGTACGGGTCGGTGAAGATGTGGGCACATCTGCAGCGCAAAGGCATCCCGGTGGCGAAGTCCACGGTGGAACGCCTGATGCGCCGAAACGGGTGGCAGGGCGTACGCCGCCAGAAGGCCGTGCGCACCACGATCGCCGACCCGGCGGCGGTGAGGCCACCGGATCTGGTGGATCGCCAGTTCGGGGTGGGCGCACCCAACCAGCTGCTCGTTGCGGACTTCACCTACGTCAAGCTCGTCACGGGGGTGTTCGTCTACGTCGCATTCGTCATCGACGCCTACGCCGGGGCGATCGTGGGATGGGAGGCCTGCGCCTCCAAGCAGACCCAGTTCGTCGAATCGGCGATCCGTCAGGCCGTCGCATTGCGGTCGCGTCAGGGTCACCCGATCGAGGACGCCATCCACCACAGCGACGCAGGATCGCAGTACACCAGCGTGAGATTCGGTGAAACACTTGCCCTTTCGGGCATCCGACCCTCGGTCGGCAGTGTCGGCGATGCCTATGACAATGCTCTGGCCGAGACCACGATCGGACTCTACAAGACTGAGTGCATCCGGCCTGATTCCCCGTTCCGTCGCGGGCCGCTCACCACGGTCGGTGACGTCGAGTACATCACCGCCGACTACGTCGCCTGGTACAACCAGCAGCGCCTCATGCACCGCCTCGGCCGAGTCCCACCCGCCGAAGCCGAAGCCCAGTACTATTCCCAACACGTGACCGACCAACCGGCCGGCTCACAGAACCCCGAGGGTGCATGAAACCCGGGATGCTTCATCAAGTTGAGCGGACCTGACATCTATCGGGATCCGGCTCCGGTCACGCGTGACGTCTACACGATCAGAGCCAGTGTGGAGCAAGGCAATTCGGGTGGACCGCTGATTGATCTCGACGGTCACGTGCTCGGTGTGGTGTTCGGCGCAGCGGTCGACGATCCAGACACCGGGTTCGTGTTAACCGCCGACGAGGTCGCCAGTCAGCTCGCCAGGGTTGGAGACAGCCAACTCGTGGGCACCGGGTCCTGCGTCGGCTGAGCCGCCGGGCTCACCTCGCTCGGGTCAGGTGCACCTGCTCGAGAAATTTAGTCAGGTGCCTGTTGATTTCTTCGGGCGCCTCTTCGTGGCTGAAATGCCCTGCGCCCGCGATGGATACGTAGCGTCCTTGCGGCGCATAGCGCTGCGTACGGTCGACCGGGTCGGCCAGCACATAGGGATCCGCCTCGCCGCGCAGGTGTAGCAGCGGCACGCTGAGCTGCTGGCTCATCGACCTCATGAAGCGTCGGCCTTCATCACGCAGTTGGCTGCGCACGGCCCAACGCTGGTATTCCAATGCGCTGTGCGCGGCCGCCGGGATCTGGATCGCCGTGCGCAGATAGCTGATGGCCTCGGAAAAGTCTTCGGAGGCAAGCCATTTGCCGCAGCTACGGCTGCGGACCAGTCGCTCGATCTCGGCGGCGTCGTCCCGGGTCAACAAGCGCTCGGGCCACAACGGAATCTGGTATTGCAGCAGCGTCGGCAAAAGGGCATAACCCTGGTCGCGTCGCGTCAACGTGGATCGCCGCAACGCCGCCGGGTGCGGCGAGCTGATCAGCGCGATTGCGGACACCAGCCGCGGATGAAGCAAGGCCGTCGCCCAGCATCCCAGGCCTCCGTCGGCGTGGCCCACCAGGGTCGCCGTGGAGTGCCCCAGCGCCCGGATGAGTCCGGCCGTGTCGCCGGCCATCGTCCAGCCGTCGTAGCCGCGGGGCGGCTTATCGCTGCCGCCGTAGCCGCGCAGGTCGACGGCCACCACCCGCGCCCCGCGCAGTCCGCGCAGCTGATGCCGCCAGGACCACCAGAACGATCCGAAACCGTGCAGCAGCATCACCAGTGGGCGTGCCGTCGGAGGCGGGCCGTCGACATCGCCCAGGGCCTCGACGACGTGGAAGCGGATGCCGTTGGCGTGCACATCGAGATGGCGCCACGGCCCGTCGATGCGGGTTACCGACGGATCGGGCGGCGCCATCTACCAACCCGATGGATCGGCGGCACCGCCGTTGCCGGGCTTCGCGTGCCTGCCGTGGTGCTCGGGGAGCTGCGCGGCGGGGCCGGGGGCCTTGACGTGGCCCGGTGTCAGCGCGGTACGCGTCTCCTTGACCGATTCGATGGTCTGCCGCGGCCCCCGGATCCGGCGCACCTTGAGGAAGCCCAGCAGCGCCAGCAAGGCGCCGACCACCACCATGATCCCGAACACGATCAGGTACGCCACCCAGCGCCACAGCCAGGTATCGAGCAGCTCGGCGACGAAGAAGAAGAAAAAGAAGGTCGAGTAGAACAGCACCACCAGCGCGGCAATGAAGAAGACGCTGCCGGTGAGACCCTTCTTGACGTCCCGGGTGATCTCGGCGCGAGCCAATTCGACTTCGGCACGGACCAGCGTGGAGACCTGGGTGGTCGCATCTTTGATCAGATCACCGATCGACGGCTCGGCGGGTTTGGCGTGCGGGTCGGTCAACGGAATCGTGGTCAGGGTGCTGGGCACACCGTTCTTGCCATCGGCTTTGCTCACAGACGGTCCTCTTTCGTCGTCACCCGGCTCGCTTGTCGTCGCGGTTTATGTTGCCATGTGGCGCCCGGATAGAAGAAGCCAGACGAGGCCAGCCGAGCCCGCGCCGCCGGGTTCGAGCACCGGGTCGTTTCGCCCGACGGGCAGTTCGGTTCGGAACGGCAGGCGGTCGGTGACGCCGCGGGGCGAGCGGGCTCTGCGGCGCGTACATCGCACCCCGGCCGATTACACTCGGCCAAGCCGGTCTCGATGTCCGGCCGACCGATGGGAGTGGGGCTGTGCGGAGAGCGCACCGGTGCTTCTTGGTGGCGATGGTCGCCCTGCTCGTGACCGCGATGGGTTCGCTTGCCCGCGCCGCCGCGGCCGACGTCCGGATCCCGATCGGCGGTGGTGCGGGCATCGTCATCAACGGCGACACCATGTGCACCCTGACCACCATCGGCGGCGACGCCGCCGGCGAGCTGATCGGTTTCACGTCGGCGCATTGCGGGGGTCCGGGCGCGCAGGTCGCCGCCGAAGGTGCCGAGAACGCGGGCGTATTGGGCACCATGGTGGCCGGCAACGACAACCTGGACTACGCGGTGATCAAGTTCGATCCCGCCAAGGTGACACCGGTGGCCAACTTCAACGGCTTTTTGATCAGCGGCATCGGGCCGGAACCGGCCTTCGGTGAGATCGCCTGCAAGCAGGGCCGCACCACCGGCAACTCGTGCGGCGTCACCTGGGGGCCCGGGCAGAATCCGGGCACCATCGTGATGCAGGTCTGCGGCCAACCGGGCGACTCCGGCGCGCCGGTCACGGTCAACAATCAGCTGGTCGGGATGATCCACGGAGCGTTCAGCGACAACCTGCCGACCTGCGTCATCAAATACATCCCGCTGCACACGCCGGCGGTGGTGGTGTCGTTCAACGCGGTCCTGGCCGACATCAACACCAAACATCGGCCCGGTGCGGGGTTCAGCCCGCTGCCGGGCTGACGGCACCGGCTACTTCGCCGCCTTGATCGCGTCGAAGACGCCGGGATCGAGCAGCGTCGACGTGTCACCCAATTCGCGGTTTTCGGCGATGTCACGCAACAGCCTGCGCATGATCTTGCCGCTGCGGGTCTTGGGTAGCTCGGGCACCACGTGCACCTCCCGCGGGCGGGCGATAGGGGAGATCTCCCGGGCCACCTCAACGCGCAACTCGTCGACGATCCCGTCGTGCACGTGGAAATCGGCGCACAGCACCACGAACGCGCAGATGGCCTGGCCCGTTGTCTCGTCGGTCGCCCCGACCACCGCCGCCTCGGCGACCGCGACGTGGCCGACCAGCGCCGACTCCACCTCGGCGGTGGACAGGCGGTGCCCCGACACGTTCATGACGTCGTCGATGCGGCCCACCACCCAGATGTCGCCGTCGGCGTCGTAATAGGCGCTGTCGCCCGCGAAATACCAGCCGTGCTCGGCGAACCGCGACCAGTAGGTCTCGACGAATCGTTCCGGATCGCCCCAGATGCCGCGCAGCATCGAAGGCCACGGCTGATCCAGCACCAGGTAACCGGCCACGTGCTCACCCTCGTCGTTGCCCGGCGGCAGCTGGTCACCGTGGTCGTCGACGACCTTGGCCGAGATACCCGGTAGCGGCCGCATCGCCGAACCCGGTTTGGCCGCAGCCACTCCCGGCAGCGGGGAGATCATCGTGGCGCCCGTCTCGGTCTGCCACCAGGTGTCGACGATCGGAAGGCGGTCCGCGCCGATAACCTTGCGGTACCAGCGCCACGCTTCGGGATTGATCGGTTCGCCGACAGACCCCAACAGCCTCAGGCTGGACAGGTCGTGCGCGTCGGGGATCTCGCGTCCCCACTTCATGAACGTGCGAATCAGCGTCGGGGCGGTGTAATAGATTGTGACGCCGTACTTTTCGATGATTTCGAAATGCCGGTGCTGGCTGGGCGAGTCGGGCGTTCCCTCGTAGAGGACCTCGGTGACCCCGTTGGCCAGCGGACCGTACACCCCGTAGGTGTGCCCGGTGACCCAGCCGATGTCGGCGGTACACCAGAACACGTCGGATTCGGCCTTGATGTCGAAGACGTAGTAATGCGTGTAGGCCGCATGGGTCAGATAGCCGCCGCTGGTGTGCACGATGCCCTTGGGCTTGCCGGTGGTTCCCGAGGTGTACAGCAGGAACAACGGCTGCTCGGCGGCGAAGGGCTCCGGGGTGTGTTCGGGCGACGCGGCGTCGACGACATCGTGCCACCACAGGTCGCGGTCGTCGTTCCAGGACACGTCAATCCCGGTGCGCCGCACCACAAGTACGTGCTCGACGGGGCTGTCGCCGTTGACGGCCTCGTCGGCCGCGTCCTTCAACGGCGCGGGCTTGCCGCGGCGGAACTGGCCGTCGCTGGTGATCAGCAGCTTGGCCTGCGCGTCGGCGATGCGCGCCTGCAGGGCCTTGGCGGTGAAGCCGGCGAACACCACGCTGTGCATCAGCCCCAGCCGTGCGCAGGCCAGCATCGCGATCACCGCCTCCGGGATCAGCGGCAGATAGATCGCGACCCGGTCGCCGGCGACCAGACCGAGGTCGGTCAGCGCGTTGGCCGCCTTGCACACCTCGGCCTGCAGATCGGAATAGGTCAGGCTGCGGTGATCGCTGACGGGTTCGCCCTCCCAATGGATGGCGACCCGATCCCCCAGGCCGGCCTCCACGTGACGGTCGACGCAGTTGTAGGCGACGTTGAGCTTGCCGTCGGCGAACCACTTGGCGAACGGAGCCTCCGACCAGTCCAGCACCTCGGTGAACGGCGTCGCCCACGTCAGACGATTGGCCTGCTTGGCCCAGAACGCCAGCCGGTCCTGCTCGGCCTCGCGGTACACCTCCTCGCCGGCGTTGGCTTGCTCGGTGAACTGCGCCGGCGGCGGATACGACGAGGGGCCTGCGGTGTTGGTGGCTGTCACTGGGTTCTCTCCTGTGTCGAGGCTCGTCAACCGTCAGAGAGCCTAGCCCTACAAGGTGAAATGCGACGCGTGAAATCGAGGTCAAAGCGTGCCCGCATGCCGGATAATCACCGGTGTGCCGGGACATGGGCGGGGCCTCCGCCGACTAATCCCCAGCTTTGCCGCGGCCGCAACGATTTACGCGGCGGCCACCGCGCTGGGGTGGCCGGTATCGGCCGTGCCGATTGAGGGCGACCAGGCCACACCGTGCCGGTCGGAGCAGGTCGCCGTGAACGTCTCCCCGGCACAAGGCGCGGTGGGGCACCGCGGGCTGGCCCTGATGTTCAGCCTCGCCGGCGGGGCCGACCCGTGCACGCTCACCGGATACGCCGGGGTCGACTCGGGCGCCGGTGGGCCGTTGATTCATGCCCTGCCGACGCTGCGCGGTTACATGGGTGGGCTGCCGGACGGCGTCGATGTCCCGCCCGCCGTCCTGCTGTCGATATCGACGCAGGGGCAGGCCATCGTGGAGGGGATGGCCGTGGACGCCGACGGTGCCCCGTGCCCCACCTACACCGAGCTGAGCGTCAACCCGCCCGACACCGAAATCGTGCTCACCGTAGCGGCGACCATCGACGCCTGCGCGCTGCAGGTGCACCCGATCACCGCGGTCTGACCGGCGTCAGTCGGCCCTGACCAGGCAGTAGACCCGGGCGGGGATGGGGTAGGCGATGCCCCTGCTGTCGGACGGGCACTGGGACTTGTCCGAGCTGCCGTCGATGCGCTGACTGACCTTGACTTGCGCCCGACCCGGCTTGTCGCAGTCGCCCAACCTGAGCGTCATCGCGTCGCCATCACTAATCATCTGATAGCACTGGCCCTCTTTCAGGTTGACCGCAAAGCACAGGATCGTCGAGTCGTTGGTGAAGCGGTCATAGACGGAGTGCTCTCGTTTTCCGTCGGGGCACGTGTCGCCGGCGCCGCTCCTGGAAGCGAGTTCGTAGGTCGCCGCCGGGTCGGTGCAGCCGCCGCTCGAGCTTGAATTGAAATGCTGTGCCTTGTAGTCGCTTTCGCTGATGCAATCGCCCACCCGCAGGGACGTGTCGCCGATCGCGCTGGCGCCGAGCCCGGCCAGGACGCGCGCCGCGTTGCCCAGGATGCCCAGCCCGCCCAACGTCAGCAGCACGGCGCCCATGGTGATGAGCGCGGTAGCCGACTTCGGCGCCCGCGGCCGCGGCGGATGGCCGGGTGCGTAGCCGGGATACGGCGCAGCGGCATAGCCCGGCGGTGGCGGGTAGGGGTAACCGGGGTGGACCGGAAAGCCCGGGGGGTACTGCGGCGGGTAGCCGGGAGCCCGTCGACGGCTGCGCGAGCGCTCCACCAGCCCAATGACCAGGCAGACCAATCCAATTGCGGGCACACCGAGCCAGAACATCAAATAGCCTGCTCGCACACCCGATTCATGCGAGGCCAGATACGCCACGGTCACGACCGGATTCTAAATTGGGAACCCGTACCGGGCACTTCACCGCCGCGCGGCTGCAGGCCCTAGGGTCGGGTGTCATGCGTCGGATGCGGACCCCGGTGGCCTTGCTGGCCCCGGTTGCCGCCGCGATGCTGATGGTCGCCTCGCTGGCCGGTTGCGGTGGCGGCGTCCTCAGCCCAGACCTGGTGGTGGTCAACGGCGGGGAACCGCCCAACCCGTTGATCCCCACCGGCACCAACGACAGCCTCGGCGGGCGGATCCTGGATAGGCTCTTCGCCGGGTTGATGTCCTACGACGCCGCCGGCAATCCGTCGCCCGAGGTCGCCCAGTCGGTCGACACCACCGACAACGTCAACTACCGGATCACCCTCAAACCCGGCTGGACGTTCACCGACGGGTCGCCGGTTACCGCCCATTCCTTCGTCGACGCCTGGAACTTTGGGGCGCTGAGCACCAATGCCCAACTGCAGCAGAGCTTTTTCAGTCCCATCGACGGCTTCGAAGCCGTCGCCGGGCTGACCGGCGGCGGCAAGCCGACCGCCACCACCATGTCCGGCCTGCAGGTGATCAACGACCGGGAGTTCACCGTCCGGCTGAAGGCACCCACCATCGACTTCACGTTGCGACTGGGGCACAGCGCGTTCTATCCCTTGCCGCAGGCGGCCTTTCGGGACATGAACGCTTTCGGTCAGCACCCGATCGGCAACGGCCCGTACACACTTGCGGACGGCCCCGACGGGCCCGCGTGGGAGCACAACGTCCGAATTGACTTGCGGCCCAACCCCAATTATCACGGCAACCGCAAGCCGCACAACAAGGGGCTGAGGTTCGAGTTCTACTCCAACCTGGACACCGCCTACGCCGACCTGCTGTCCGGCAACCTCGATGTGCTGGACACGATTCCGTCCAGCGCGTTGACGGTCTTCCAGCGCGACCTGGGCGGCAACGCCGCCAGCGGACCCGTCGCCGTCAGCCAATCACTCGACACGCCGCTGCGGTTGCCGCACTTCGGGGGTGAGGAAGGTCGACTGCGGCGGTCGGCGTTGTCGGCGGCCATCAACCGTCCGCAGATCTGTCAGCAGATCTTCAACAACACCCGCAGCCCGGCCCGCGACTTCACCGCCAGTTCCTTGCCGGGATTCGACCCCAACATCGTCGGCAGTGACGCGTTGGACTTCAACCCCGAACGGGCACGCCAACTTTGGACCCAAGCAAACGCGATATCGCCGTGGAGCGGCCGGTACGCCATCGCCTACAACGCGGACAGCGGCCATCAGGAGTGGGTGGACGCGGTGGCCAACAGCATCAAGAACGTGCTGGGCATCGATGCCGTCGGTGCGCCGCAGCCCACCTTCGCCGGGTTTCGCACCCAGATCACCAACCGGACGATCGACACCGCGTTCCGGGCCGGCTGGATCGGCGACTACCCGTCGATGATCGAGTTCCTCGCCCCGCTGTACGCCACCGGTGCGGGCTCCAATGACGTCGGATACTCCAGTCACGAGTTCGACGCCGGCCTGGCCGCCGCCGAGGCGGCTCCCGACTTACGGCAGGCCGACGTCCTGGTCAACGTCGCGCAACGAATCCTTTTGCACGACATGCCCGCCGTACCGCTGTGGTATTACATCGCCGTGATCGGATGGTCACCGCAAGTCGGCGCCGTCAAGGTCACCTGGAACGGGCTGCCCGACTACGAGAATCTGGTCAAGGGCTAGGACATGGGCTGGTATATCGCGCGACGGATCGCCGTCATGGTGCCCGTCTTCCTGGGCGCCACGTTGCTGATCTACGGCATGGTCTTCCTGTTGCCTGGAGACCCGCTGGCCGCGATCGCCGGCGATCGGCCGCTGACCCCGGCCGTGGCCGCCGCGCTGCGCGCCCGCTACCACCTCGACGACCCGTTCATTGTGCAGTACCTGCGTTACCTGGGCGGCGTCGTGCGCGGCGACCTTGGCCGTGCCTACTCCGGTTTGCCGGTCAGTGCCGTTCTCGCACACGCGTTTCCGGTCACGATCCGGCTCGCGTTGATCGCCCTGGTCGTCGAGGCGGTGCTGGGCATCGGGTTCGGCGTGATGTCCGGTCTGCGCCAAGGGGGACTATTCGATGCCACGGTGCTGATCACCGGACTCATCATCATCGCGACCCCCATCTTCGTGCTGGGCTTCCTGGCCCAATTCCTGTTCGGGGTCAAGCTGGGCATCGCGCCGGTCACCGTCGGCGAACGGGCGACCTTCGCGCGCCTGCTGCTTCCCGGAATCGTCCTGGGCTCAGTCTCATTCGCGTATATCGTCCGGCTGACCAGATCGGCGGTGGCCGCCAACGCGCACGCCGACTACGTCCGCACCGCCACCGCCAAGGGATTGGCGCGGCCCCGGGTGGTGACCGTGCACATCCTGCGCAACTCGCTGATCCCGGTCGTGACTTTTCTGGGCGCCGACCTGGGAGCGCTGATGGGCGGGGCCATCGTGACCGAAGGCATCTTCAACATCCATGGTGTCGGCGGCGTGCTCTACCAGGCGGTCACCCGGCAGGAAGCGCCGACCGTGGTGTCGGTCGTGACGGTGCTGGTGCTGATCTATCTCGTCACCAATCTGATGGTGGACCTGCTCTACGCCGCCCTGGACCCAAGGATCCGCTATGCCTGAGCACTCAGGATTTTGGGGCGAAACCTGGCGAAAACTGCACCGCCGCCCGAAGTTCGTCGTCGCCGGCGTGCTGATCGTCCTCATCCTTCTCGTCGCACTGTTTCCCGCGTTGTTCACCCACGCCGACCCCGGCTACGCCGATCCCGGCCAAAGCCTGCGCGGCCCGTCGGCGGCGCACTGGTTCGGCACCGACCTGCAGGGCCACGACATCTACACCCGCACCATCTACGGGGCGCGGGCGTCGGTGACGGTCGGGTTGGGCGCCACGCTGCTGGTGTTCGTCGTCGGCGGGATGTGGGGCGCGCTGGCCGGCTTCTACGGCGGGTGGCTCGACGCCGTCGTCTCTCGTGTCGCCGACATCTTTTTCGGGCTGCCGCTGCTGCTGGCCGCGATCGTGCTCATGCAGGTTCTGCACCATCGCACGGTGTGGACCGTGATCGCCATCCTGGCCATCTTCGGCTGGCCGCAGATCGCCAGGATCGCTCGCGGCGCCGTGCTGGAGGTGCGCGGCAGCGACTATGTGCTTGCCGCCAAAGCGTTGGGGATGAGCAGGTTTCAAACGCTGCTGCGGCACGCCTTGCCGAACGCGGTGGGGCCGGTGATCGCGATGTCGACGATCGCATTGGGGGCCTTCATCGTCACCGAGGCCACCCTGTCCTACCTCGGTGTCGGGCTGCCGCCGTCGGTGGTGTCGTGGGGCGGCGACATCAACCTCGCCCAGACGCGGCTGCGGGCGGGCTCACCCATCCTGTTCTATCCCGCCGGCGCCTTGGCCACGACAGTGCTGGCGTTCATGATGATGGGTGACGCGCTCCGCGATGCCCTGGATCCGGCGTCGAGGGCGTGGCGGGCATGAGCGGTACGGTTTCGCCGCTGCTGTCGGTCGAGGGTCTGGAGGTCGGCTTCGGCGACCACGCCGCGGTGCGCGGGCTGGATCTGAGCGTGCTGCCCGGCCAGACCGTCGCGGTGGTGGGTGAATCGGGTTCGGGCAAGTCCACCACCGCCGCCGCGATACTCGGGCTCCTTCCACCCGGCGGGCGAATCACGGCCGGGCGCATCATGTTCGACGGCGTCGACATCTCGGCCGCTGATCGCCGGGCGCTTCGCTCGATCAGGGGGCGCGAGATCGGCTACATCCCGCAGGACCCGATGACCAACCTCAACCCGGTGTGGAAGGTCGGCTTTCAGATCCGGGAAGCCTTGCGGGCCAACACAACCGATCGAGGCACCCGCCAGCGGGCGGTGGAACTGCTCGCCGCGGCGGGCATGCCGGATCCGGCAAGGCAAGCCGGCCGTTACCCCCACCAGTTGTCCGGCGGCATGTGTCAGCGTGCGCTGATCGCGATCGGGCTGGCGGGCCGCCCGCGGCTGCTGATCGCCGACGAACCGACGTCCGCGCTGGACGTCACCGTGCAGCGGCAGGTCCTCGACCATCTGCAGCGGCTCACCGCCGAACTCGGCACCGCGCTGCTGCTGATCACCCACGATCTCGCGCTGGCCGCCGAACGCGCCGAGTCCGTGGTCGTCGTCCATCGCGGGGTCGTGGTGGAATCCGGTGCGGCACGGTCGATTTTGTGCAGCCCGCAACACGAGTACACGCGACGGCTGGTGGCCGCGGCGCCGGCGCTGACGATCCGAGGCCCTGCGCGGCCCCGCGCGACTGCGGAAACCGAACACCCCGAGGGCATCCTCGTCGCCGCCGCGCTGACCAAGGTCTACCGGGAAGCGCACGGGGCGCCGTGGCGGCGCACCGAATTCCGAGCGGTCGACGCGGTGTCGTTTCGGCTGCGCCGCGCGAGCACGTTGGCGATTGTCGGGGAGTCGGGGTCCGGGAAATCCACCGTGGCGCGGATGGTGCTCGGACTCCTACCGCCCACCTCGGGCACGGTGGAATTCGACGGCGTCCGGATCGACGGCGCGATGCCCCGGGACAAGCAACTGGCATTCCGCCGCCGGGTACAGCCGGTGTTCCAAAACCCCTACAGCAGCCTCGATCCCATGTACTCGGTGTTTCGTGCCATCGAGGAGCCGCTGCGCATTCACCGCGTCGGGGACCGCGGGCAGCGCGCACAAGCGGTGCACGACCTCATCGAGCAGGTGGCGCTGCCGTCGTCGGTGCTGGACCGGTTGCCGCGCGAGCTCTCGGGTGGGCAACGGCAACGGGTGGCGATCGCTCGAGCGCTGGCGTTGCGGCCCGAGGTGCTGGTCTGCGACGAGGCGGTGTCGGCGCTCGACGTGTTGGTGCAGGCGCAGATCCTTGACCTGCTGGCCGAGCTGCAGGCCGAACTGGGCTTGGCCTACCTGTTCATCAGCCATGACCTGGCGGTGATCCGGCAGATCGCCGACGACGTCCTGGTGATGCGGGCGGGCCGGGTGGTCGAGCACGGGCCCACCGGGCAGCTGTTCAGCGACCCCGGGCACGAATACACCCGGCAGTTGCTGGACGCCATCCCGCACCCGCTGGAATCCGGCGGGGATAGGTTGTGAGGTTGTGACGGCTGATCCGCTGGCCCCCCTGATGGAACTGCCCGGCGTCGCCGAGGCCAGTGACCGCGCCCGCGACGCGCTGGGTCGTGCCCACCGCCACCGCGCCAACCTGCGGGGCTGGCCCGTGACCGCCGCCGAGGCGGCGCTGCGGGCCGCGCGCGCGTCGTCGGTCCTGGACGGTGGCCCCGTGCGGCTGGAGGATCTCGCCGATGCCGGGCAGATCAGTGATCCGGTGTTTGCGGGCGCGCTTCGGGTGGCCCAGGCGCTGGAGGGCGGCGAGGGCCCCGTCGTCGCCATTTGGCGACGGGCACCGCTGCAGGCGCTGGCCCGTCTGCACGTGCTGGCCGCGGCGGAACGGGTCGACGACGAGCGGTTGGGTCGCCCGCGGGCCGATGCCGGGGTGGGGCCGCGACTGGAATTGTTGGCGGACCTGGTGAACGGGCGCACCCGGGTGCCGGCGCCGGTGCTTGCCGCGGTCGCCCACGGCGAGCTGCTGACGCTGAAGCCGTTCGGCAGCTCCGACGGTGTGGTGGCGCGGGCGGTGTCGAGGTTGGTGACCATCGCCAGCGGGCTGGACCCGCACGGGCTGGGTGTCCCCGAGGTCAGCTGGATGCGTCAACCCGCCGCGTACCGCGACGCGGCGCAGGGATTCGCCGAAGGTACGCCGGAGGGCGTGGGAGCCTGGCTGGTGCTGTGTTGCCGCGCAATGAAAGCCGGTGCGCAAGAGGCTGTGTCGATCGCCGACTCGATGTCGAACCGATAGCTGAAGCGGTAGCCACAGGCCCGTAAAATGTCACCGGAAATGGGCCGCAAAAATGTAGAGCGGGCGACGTTCCGAATGTTCGGTCCGCCGCCCGCTAGCACGGTACTCGGTTACCAAGCGTGCATTTCGGGGTTGCGTGGGTTGGCCTCGGCGATCTCACGACGCTTGTGGTTGCAACCCCACCCAAAGGGTCGTCGATACCTTCCGCATTTTCGCAATTTCGCAGGCCCGCAACACTTCTGCCATCTTCGCGGCTATGACTCCGCGTGGGTGCCGAGCACCATGCTGGGCGCCCGGGTCGGGAGAACGAACCTTCTCTTCCGGATCGATCTAGGCCTCACCAGGCTTCCGTGGTTCCTTTGTACTACTAGACCCCTAGCACAGCAAGGGTCAATTCGCGAGTAGTCCCGAATCCGGTTCGGATTACGCGTTTAAGGAGTTTGCTGCCGCGCGCCGCTGGGCTCAGAATGCGTAGCGGCGTATCAACGAATAGGTGACCGCGCCGGCCGCCAGCGCGCTGATGCTCACCGCGGCCGTCGTGGCGATCGCGGCACCCGAGGGTGCCGGGATGCGGTCGCGCAAGGACACCGGCCGGGAGAACGACATCACGGGCCACCCGCGCTCCAGGGCTTCCCGGCGCAACCCGCGGTCGGGATTCACCACGCTGGGGTGGCCGACGGACTCGAGCATCGGCAGATCGGTGATCGAGTCGGAGTAGGCGTAGCAGTGTTCCAGCGGGTAGCCCTCGCGCGCGGCCAGCTCCCGGATCGCTTGCACCTTGCCCTCGCCGTAGCAGTAGAACGCGATCTCGCCGGTGTACCGACCGTCCTCGACGACCATCCGGGTTGCCATCGCGTGGGTGGCGCCCAAGGCCCGGGCGATGGGGGCGACGATCTCTTCCCCGGATGCCGACACCACCACGACGTCACGCCCGCACAACTTGTGGGCCGCGATCAGGTCGGCGGCCTCGGCGAACACCAACGGCGTGACGATGTCGTGCAGCGTCTCGTTGACGATCGACTTGACCTGCTCGACGTCCCAACCGGTGCACATGTTGGCCATGTGGGCGCGCATCCGATCCATCTGGTCATGATCAGCACCGGAGAGCAGATAGATGAACTGCGCGTAGCTGGACTTGAGCACGGCGCGGCGGTTGAGCAGGCCCTGGTTGAAAAACGGTTTGCTGAACGCCAGGGTGCTGGACTTGGCGATGATGGTCTTGTCCAGGTCGAAGAAGGCCGCCGTGCGGGCGTGAGGACTGGTGGTTGCCGCTGATTGCTCCGGGGCTGACTGCTCCGCGGTGGGGTCGAAGACGGTCACCGACCCAGCATAGGTCGGGTGTCTCGCGAGGCCGTGATCCCGCACCGAAAATGGCCGCTCAGGGCGGTTCGGGGTCCGGATGGAAGAGTGTTTACGCGGCTCAAGCTGTTTTTTCAGTAAAAGATCTTCTTGCGTTACTCCGGCTTGTCATGTGTATAGTAAGCATTACTCGGCCTGAGCCGAGGGTGTATCAGCCCGACCCCCCGGGGCTGATACACGACGACCCTCGCCTCCTCCCCCCCTGGCGGGGGTCGTCCCTTTTCTACGGCGGGTTTTCCTCGCCTCCCGGCACCGGGCTCGGCTCCCGATGCGTTGCGGGAAACTGTGTCCGTCGTCGCTGGCGGCGTGGTCCCGCGACGCGTTTGTGCACACTCGCGTCTCTATCCACAAATCCGCATTTGGGACTGTTGTGCCAAGGTCACGGCCCCGCACAGTGGTCGGATGACAAGCGGCTCCGGAGTTGACGCGACGGGTTCGGCTGGTGTGTTGGCGGTGCTGGCGGAGTCCGACATGCGCGCCGAGTTGGACCGGGTGGCGGCCGCCGCCGGCGTGCGGGTGGTCCATGCCAGCGATGTGGCTCCGGTCAGCCGCAAGAGTTGGGCGGCGGCCGCGGCCGTCGTGCTCGACGCGCGGGCCGCGGCCCGGTGCGGGCGATGGGCGCTGCCGCGCCGTGATCACGTGACCGTCCTGACCGTCACCGAACCCGAGACGGCAACGTGGGCGGCTGCCGTCGGGGTCGGCGCCGAGCATGTGTTGCAACTGCCGGGGCAGGAAGCGGACTTGGTCGGCGCCCTGGCCGAAGCGGCCGAATCGGCGCGCGACGACGGGTCCCGTGGCCACGCGGTCGCCGTCATCGGGGGATGCGGCGGAGCCGGCGCCTCCCTGCTCGCGGTCGCCCTGGCCCAGGGCGCAACCAACGCGCTGCTGGTGGACCTCGACCCGTGGGGCGGCGGGCTCGACTTGTTGCTGGGCGGCGAATCCACTCCGGGGCTGCGCTGGCCGGACCTTGCGTTGCAGGGCGGGCGGCTCAACTGGTCGGCGGTACGCGATGCGCTGCCGCGCCACCGCGGAGTCAGCGTGCTGTCCGGCACCCGGCGCGGATACGAGTTGGACGCCGGGCCGGTGCACGCCGTCATCGACGCCGGCCGCCGCGGGGCGGTCACCGTCGTCTGCGACCTCCCCCGCCGACTCACCGACGCGACCCAGGCGGCGCTGAGCGCGGCGGATCTGGTCGTCGTCGTCAGTCGCTGCGATGTGCGCGCGTGCGCGGCGACCGGGGCACTGGCGCCGGCCTTGGCGTCCCTCAATCCCAATGTCGGCCTGGTGGTGCGGGGCCCCTCGCCGGGCGGCTTGCGGGCCGCCGAGATCGCCGAGATCGCCGGATTGTCATTGCTGGCCACCATCAAAGCCCAGCCGCAACTGGCGGAGCAGGCCGACCGGGGCGGCCTGCGGTTGGGGCGGCGCACGGCGCTCGGGGTGGCGGCCCGGCAGGTGCTTGCCGTGTTGCCACCCGGCGCGGCGCGGCGGCGGGCGGGGCAGAACGGCCGGGCGGCGTGAGCGGTTCGCTGATCGAACGTGTCCGCGAGCGACTGGCCGGCGAAGCCGGCCCGCCGGGGGCCCCGTTGGCGGCTTCGGTGGTGGCCGCCGCGATCCGGGCGGAGTCCGGCGGGATGCTCGGCGACACCGAGGTGCTGGCCAATCTCCGGGTGCTGCAGACCGAACTCACCGGCGCCGGCATCCTCGATCCGCTGCTCTGCGCCGACGGGACGACCGACGTCTTGGTCACCGCACCGGATGCGGTGTGGGTTGACGACGGCACCGGTCTGCGGCGCACCGAGGTTCGTTTTCCCGACGAGGCGTCGGTGCGGCGGTTGGCGCAGCGGCTGGCGCTGGCCGCCGGACGGCGCCTCGATGACGCGCAGCCCTGGGTGGACGGCGAGCTGACCGGCATCGGCCCCGGCGGGTCCGCGGTGCGGCTGCATGCGGTGTTGCCGCCCGTGGCGGCCGCGGGCACCTGCGTGTCGCTGCGTGTCCTACGGCCCGCCAGCCAGGATCTGTCGGCCCTGACCGCCGCCGGTGCGATCGAGCCGGCGGCCGCCGCGCTGGTCACCGACATCATCGGCGCGCGATTGGCGTTCCTGGTCAGCGGCGGCACCGGCGCCGGCAAGACGACACTGCTCGCCGCGATGCTGGGTGCCGTATCGCCGGCCGAACGGATCGTCTGCGTGGAGGATGCCGCGGAGCTCGCGCCGCGGCACCCGCATCTGGTGAAGCTGGTCGCGCGGTGCGCCAACGTCGAAGGCGTCGGCGAGGTTCCGGTGCGCCAGCTGGTCCGGCAGGCGCTGCGGATGCGGCCCGACCGCATCGTGGTCGGCGAGGTCAGGGGCGCCGAAGTGGTGGATCTGCTGGCCGCCCTGAACACCGGGCACGACGGCGGCGCGGGCACCGTGCACGCCAATAGCCCCGGGGAGGTTCCCGCCCGCCTGGAGGCCTTGGGTGCACTCGGCGGCCTCGATGGGGCCGCACTGCACAGCCAACTCGCCGCCGCCGTGCAGGTGCTGCTGCACGTCGAGCGTGACCGCGCCGGGCGGCGGCGACTCAGCGAAATCGCTGCGCTGCAACATGATCAAGGCCGGGTGCGGGCGGTCACCGTATGGCATGCGGATCGCGGGATGACGGACGCCGCGCCGCGGCTGCGGAATCTGCTGAACAGCCGGATGCCGGCGTGAACGGCCCGCTAGCCGGGGCGCTGCTGTTGTCGCTCGCGCTCGTCGTCGTTCGGCCCTCGCCGCGACGACGATTATCGGCGTCACGACGGCGCCGGTTCTCACCGGCCACCGGGGCTCGTGGGGCGGCCTGCGTCGCCGCGGGCATCGGCTGCGCCACCGCCATCGCGCTGCCGCTGACCGCTGTCCTGTGCGTCGCGGTCGTGGGCGCGACCGTGGGCCTGCGTTACCGGCGGCGCCGACGTATCCGGCGCGCGGCCACCGAGGGTCACGCACTGCACACCGCGCTCGAGGTGCTTGTCGGTGAATTGCGGGCCGGCTCGCATCCGGTGCGCGCGTTCTGCGTCGCCGCCGACGACACCGGCGGCGCGGTAGCGGTATCGCTGCGTTCGGTGGCGGCGCGGGCCCGGCTGGGTGCCGACGTCGCGGCCGGCCTGGCCGCGGCGGGCCGCTCCTCGGCGCTGCCCACCCATTGGGAGCGGCTCGCGCTGTGCTGGCGACTGGCCAGCGACAACGGGCTGGGAATAGCCACCCTGATGCGCGCCGCCCAGCGCGATATCGCTGCGCGGCAACGGTTCTCGGCTCAGGTGTCCTCGAGCATGGCCGGCGCGCGCGCAACCGCGGCGATACTGGCCGCGCTGCCGCTGCTCGGCGTGTTGCTGGGGCAACTGATCGGGGCCCGGCCGCTGGGCTTCTTGCTGAGCGGGCACGCGGGCGGGTGGCTGTTGCTCATCGGCTCGACGTTGGCCTGCGTCGGTCTGCTGTGGTCCGACCGCATCGCCGATCGGGTGGCGTCGTGAGTGCGGCGGCGACGATGCAAAGCGCGGCGGCGCTCCTGGCCGTGGCGCTGTGGATCGGTCCCGGTCCTGCGCTGGTGCGAAGCCGCGCAGGGATGCCGGCGCGTGGCGGCCGGCTGCGGCGGCGCGCGGCGCCGGCGCGCGGCCTTGACCCGCTGGCGGTCGCCTCCTGTCTCGACGTGCTGGCCGTGTGTCTGGAGGCGGGCATGGCCGTGTCTGCCGCCGCGGCGGCCGCCGCGCCGTCCGCACCGCCGAACCTGGCCAGGGTGTTGCGCCGCGCCGCCGACCTGCTCGCACTGGGCGCCGATCCCGCTGTCGCATGGTCCATTCCGTCCGGACCGCAAAATCCGGCCGACCCGCAGATCGATGCGTTGCTGAGGCTGGCCCGGCGATCGGCGTCCTCGGGTGCGGCGCTGGCCGGTGGCGTCGCCGACTTGGCGGAGGAATCTCGGCAGGACACCGCGCACGCGGCGACGGCGGCCGCCGAACGGGCCGGCGTACTAATCGCCGGGCCGCTGGGCCTGTGCTTTCTGCCGGCGTTCGTCTGCCTGGGCATCGTCCCGGTCGTAGCCGGCCTGGCCGGTGATGTCCTGCAGTCGGGCCTGCTGTGAAACGAAAGGAAGCCATTGATGATCAACATGTTTCGCGAATTCTCTGCGCGGGTCGCCTTGCTGGCCGCCGACGAGTCGGGCATGTCGACGGTCGAGTACGCCATCGGCACCATCGCGGCGGCCGCCTTCGGCGCGGTGCTCTACACCGTCGTCACCGGCGATTCCATCGTCTCGGCGCTGACCAACATCATCGGTCGTGCGCTCAACACCAAGGTGTAGCCGGTGCCAGCACCGTCGAGGCGGCACTGGGCATCGCCGCGCTCGTCGTGGTGCTGGTGTTGTGCCTGGCCGGGATCACCGCGATATCGATGCAGGTGCGCTGTGTCGACGCCGCCCGCGAAGCTGCCCGGCTGGCGGCCCGCGGCGACGAGCGCTCCGCGGTGTCCGCCGCCCGCCGGCTCGCGCCCGCCCGTGCGCGGGTCGACCTGCGCCGCGACGGGGATTTCCTGGTGGCTACCGTCGTCGCGCATTCGAAGTTATTGCCCACCATCGATATTGCGGCCAAAGCCGTCTCGGCGGCCGAACCGTCGCGATGATCGAGGCTCCGCCACTCTGGTCGCCGCCTGGATGGTCGTGGTGCTGCTGACGGCGACCGGGGCCGGCGCGTACCTGGGCTCGGCGGTGGTGGCACGCCACCGCGCGCAGGCGGTGGCCGACCTGGCCGCCTTGGCCGCCGCCGCCCGGCTGAGCTCCGGGGGGGCGGCGGCCTGCGCGGTCGCCGCGGGCGTGGCCCGCCGGATGCGGGTCGACGATATCCGTTGCGTGGTCGACGGTCTCGATGTCGTCATCACGGCGCGGGTGGCGGTCGCTTTCGGCGGCGCGGCCAGGGCCGCCGCGCGGGCGGGCCCGGCGACCGGGGCATCGGATTAGGGCGCTGCGTCGGGGGGTGGCGACAAACCCGCGGTGGCCAGTTCCTCGTCGGTGGGTAAGCGCAGCGATACCAGCCCGGCGTACGTGTCCGTTTCCAGCTCGATGCGGTTGACGGTGACGTGCACTGGCACCCAATCTCCGTCGTGCCCGGGCAACCGCAACACGCGACTGGTGGCGCCCCCGCTGAATTCCCTTGTCATGGTGGACATCAAGTCCTGGTCATCGGGGTGAACCCGGGGCTTGCCCGCCTCGATGGTGCGCCAGTCGTAAAAGGTGCAGGGCTCGTCGAGCCATTTCAGCAGGGTCCAGGTGTTGAGGTCGATCAGCGCGCGATGAACCCCGGCCTGGGCGAGGCCGCTGAGGATCCGCTGCGCCAGATCGTCGGTCGACACCTCTGGGCCCTTCAATTCGGACTGCCAGTTGATGGCCCGCGCCACCAAGTGCTCCCGGCCGTCGGGTCCCGGTTCCAGGATCGTGCGCGCGACAAAACCGATCCGGATCGACTCTCCGCGCCAGTCGGTGAGATCCCAAGTGCTGCACAGCGTTTGGTCGGGCTTGGCCTTGACCGCCATGGCCAGCACTTTGGTTTCGTTCGGGTTGAGTTCACGGGACGGGAGGTCCTCGGCGAAGGCCCTGCCGAAGGTGACTTCGACTTCGGGGTTCTTGCCGCTGTTGATCAGCGATTCGCGGGTGTCGGTGGCCACCCCGAGGGTCAGGTCCCACTTCAGTGGCCCCGGGATCGGCCGCTCGGGCGGGTCGGTGTCCGCGGGGCCGGTCCAGACATGCACGCCGTGGATGAAGCCGTCGGACATCACCACCGGCTCGGTGCGAATGATGCGGTCGCGTTTGGGCGTGATGCTGGTTAACGCCTGGCCGGTCTGCACCGACTCGGCGATGGCCGTGCGAACAGCGGCGAGATAGGGGCTGCGGCGCAGGAACGTGGTGATAGGGACGAGATTTTTGAGCTGGCGGCCCTGCGACACAACGGTGGGGTCTCCGCCGAGTGTCTCCACGAGCAACCAGTCGTGGGCCATGGGGCCGATTTTACGGTGAGAGGACGGGTCGTCGACACCCTCACCGCCGGTGGCGGTGGATCGACGGGTCGTCATCCACGCGGATCGTTCTCCCGCGGCCCCTGCGCCAACTCTGCGAGAACCAGCTTGAGCACCAGCACGGCGCCCGCCTTGTCAAGCGGGTCGTTGCCGTTGCCGCACTTGGGGGACTGCACGCACGACGGGCACCCCCAGGGACACTCGCACGCCTCGATGGCGGCGGCCGTCGCACCCAGCCAGGTGCGGGCCCGGCGAAAGCCCCGCTCGGCGAATCCCGCGCCGCCCGGATAGCCGTCGTAGACGAAGACGCTGGGCAGCCCACGCGGATCGGGCCCGACCGCGGTGGACAGGCCGCCGATGTCCCCGCGATCGCAACTGGCCACCAGCGGCAGCAGGCCGATCGCCGCATGCTCGGCGGCGTGCAACGCTCCCGGGATCTGCGTCGCCTCAATGCCCTTGCGCTGCAACGCATCCTCGGTGATGGTGTACATCACCGCCGTGGTGGCCAGCGTGTGTTCCGGCATGTCCAATTCGATGAAGTCGATCACCTCCCCGGAGAGCCGGCGGCGCAGGAAGCCCACCACCTGGTGGGTGACCCTGACCGGCACCAGGCCCAACGTGACCGGCCCGAACGCCAGGCGCTCGCCCGCGCCGGTGACGGCGATATCGGTGATCTCCCGCGCGAACGTCGCGTAGCCCGGGTCCTCGGCGTGTACGAACGCGATGCCTTCCTCGGTGTCCAGCGAGTCCACCACGTAGCTGTCGCCCTGATGCAGGTACACCGCGCCGGGGTGGACGGTGGCCGGTGCCTGACCGGCGCCGGCGCTGCCCAGCAACCTGCCGGTGTCGGCCTCCACGATGACGATCTGGCCGCCCGCCGAGCCCCGGATGTCCACGGCGGCATGCGGTTCCAGTCCGGGCACCGGAAAGTACTTGCCGGCACGTCGCCGCAGTAGGCCGTCGTCGACCAGGCCGTCCGCCACCTCGGTGGCGCCGAGGGTGCGCACCTCGGCCTCGTCCAGCGGCAGTTCGGTTGCCGCGCACAACAGCTGCGGACCCAGGATGTAGGGATTGGCCGGGTCGATGACGACCCGCTCGACCGGCTTGTCCAGCAACGCGGCCGGGTTGTGCACCAGATACGTGTCCAGCGGATCGTCGCGGGCGATCAGTACCACCAGCGCGCCCTGGCCGCGTCGCCCGGACCGGCCGGCCTGCTGCCAGAACGACGCAACCGTGCCGGGGAAACCGGCGAGCACCACCGCGTCCAGTCCGGCGATGTCCACCCCCAACTCCAGCGCATTGGTGGTGGCCAGGCCCCGCAACCGGCCCTCGGCCAGCGCACGCTCCAGCGCGGTGCGGTCCTCCGCGAGGTAACCGGCACGATACGACGCCACCGTGCGGGACAACTCCGGAGCGACGTCGTCCAACCTCGCCTGGGCGCCCAGCGCGGTCAATTCCGCGGCCCGCCGCGACCGCACGAACGTCAACGTTTGGGCGCCCTCGGCGATCAGATCCGCCATGACGCGTGCCGCCTCCGCACCGGCGGAGCGGCGCACCGGCGCGCCGTTCTCACCGGTCAGATCGGCCCGCAGCGCGGGCTCCCACAACGCCACGGTCCGGGCGCCCTGGGGTGAACCGTCCTCGCTGACCTCCTCGACCGGCAACCCGATGAGCTCGGCGGCCGTCGCGCCCGGCGAATCCGTTGTCGCGCTGGCGAAGATCACCGTCGGCGAGGAGGAATAGCGGGCGCACAACCGCAGCAGCCGGCGCAGCACCATCGCCACGTTGGACCCGAATACCCCACGGTAGTAATGACATTCGTCGACCACCACGAATCGCAGACCGCGCAATAGGACGGCCCAACGGGCGTGATTGCGCAATATCGACAGATGGATCATGTCGGGATTGGAGAACAGCCACCGCGAACGTTCCCGCGCGAATCGTCGGACCTCGGTCGGGCTGTCGCCGTCGTACGCCGTGGGTGCGACGTCATGAAGCCGCGGGATGACCGCGGTCAGTGCGTGCGCGGCTCGCAATTGGTCGTGGCCCAACGCTTTCGTCGGCGACAGGTACAGCACGCGTGCCCGCGGATCGGTCGCCAACGCGTTGAGGACCGGAAGCTGATAGGCCAGTGACTTGCCCGACGCGGTACCGGTGCTGACCACCACGTGACGGCCCGAATGCGCCAGGTCGGCGGCCGCGAACTGATGCGACCACGGTGCGGTGATCCCGCGGCCGGCGAACGCGCCGACGATGTCGGGCTCGGCCCAGGCCGGCCACTCGTGCGGCCGGCCGCTGCGCGGTGGCAATTCGGCGACATGACGCAGCGGACGCTCGTCTGGCGCGGTTCCGGCGAGTGCGGCGGCAAGCAGGTCACTGCCGAAACTCGCCATCTCACCCCTTCGGTGGATCCGTTGTGAATCGGCCTTCACGTCGGCCGCGGAATCAGCCTTCGAATCGGCCGAAGACACAAGTCTGTCGCCGACGCGATGAACATGGTTGACTATTTGCGGTCGCAGCTTCTGTGTTCGTGTCAAACTTTCGCAGGATCGACGTTGCGGCCGCAATTCCTGCGAGGTTAATCGGTCGGGTGAAGTTCCGGCGACTCAGCGAGGTATGGCGGTCGTACCAGGCCCGGGGCATCGAAAGGCGATGCCCCGCACCCAGAAGAAAAGGAAAGATCGAGAGATGCCACAGGGAACTGTGAAGTGGTTCAACGCGGAGAAGGGCTTCGGGTTCATTGCCCCCGAAGACGGTTCCGCCGATGTGTTTGTCCACTACACGGAGATCCAGGGTTCGGGCTTCCGCACCCTCGAAGAGAACCAGAAGGTCGAGTTTGAGATCGGCCATAGCCCTAAGGGCCCCCAGGCCACCGGAGTCCGCTCGCTGTAAAGAAGAGCAGACCTGAACGGATAACCCCCCGTGCAAACCCGCCCAGCGGGTTGAGCCGGGGGGTTTCCTCATTTACTGCCGCCACCAGGTCTGCATCCCGGCCGGCCCCGGACGCCGCGCCGGTCACCTCAAGACGCGGGCGGCCCCCCTGGCCTACTGTCGGGGGCGTGAGCCAGCTTTCCTTCTTTACAGCGGAGTCGGTGCCGCCCGCGGCCACCGATCTTTCCGGGGTGCTGGCGGCGTCCGGGCAGATCGTCACCGTCGGTGCTACCGGTGAAAGTCGCGTGGCCGGCGCCCGGCTGTCGGTGGTCGTGGATCATGCCTGGCGGGCCTCGGCGCTCGCGGAGATGATCCGGGAGGCGGGTCTGGTGGCCGAGATCAGCCGGACCGACGAGGACACCCCGCTGGTGCGGACGGCAGTGGACCCCTCCCTGAGCACCCTGGCCACCGAATGGACGCGCGGGGCGGTCAAGACGGTGCCGCCGCGCTGGCTGCCCGGGCCCCGCGAGTTGCGGGCCTGGACGCTGGCGGCCGGAAACCCGGAGGGCGAGCATTACCTGCTGGCGCTGGACCCGCACGCGCCGGACACCCACTCGCCGCTGGCGTCGGCGTTGATGCGCGTCGGGATCGCGCCCACCCTGATCGGCACCCGCGGCGGCCGGCCCGCGCTGCGGATCACCGGACGCCGGAGGCTATCGCGCCTGGTAGAGAACGTCGGGGAACCGCCCGACGGCGCCGAGGCGTTGTCGCGGTGGCCGCGAGTTTAGCCAGGAGGTAACGTCCGGAATCGCGTCGGCTTTGCGCCGTTTCCGCGAATGTCAGTTTGCGCAGGCCCGCCCAAGGGTGCGAAATTGTCAGATGCCGCAGGGCGAAGGAACGGTCGCGTACCTGAATTTCACCGGAATTTTCGAAGCCGACCTGTCATTCTTCCTGCAGGTGGTCTCGCAGGGGGGACCAATCAGGGATGGAGCGTAAGGGCAGTTGGCTGACCCGAAACTAAAGGACACCAGCAGCGGCGGGAATGGCAGCCGCCGGCGACTCGTGATTGTCGAGTCGCCCACCAAGGCGCGCAAACTGGCCGGTTACCTGGGCTCCAGGTACATCGTCGAATCGTCGCGCGGCCACATCCGCGACCTGCCTCGGGCCGCCGCCGACGTGCCCGCGAAGTACAAATCCGAGCCCTGGGCACGGCTTGGGGTCAACGTCGATCACGACTTCGAACCGCTCTACATCATCAGCCCCGAGAAGAAGAGCACCGTCACCGAACTCAAGGGCCTGCTCAAGGACGTCGACGAGCTGTACCTGGCCACGGATGGTGACCGCGAGGGCGAGGCCATCGCCTGGCATCTGCTGGAGACCCTCAAGCCGAACATTCCGGTCAAGCGGATGGTGTTCCACGAGATAACCGAGCCGGCGATCCTGGAGGCCGCCGAGAATCCACGCGACCTGGACATCGACCTGGTCGATGCGCAGGAGACCCGGCGCATCCTGGACCGGCTGTACGGCTACGAGGTCAGCCCCGTGCTGTGGAAGAAGGTCGCGCCCAAGTTGTCCGCGGGCCGGGTCCAGTCGGTGGCCACCCGGATCATCGTCCAGCGCGAACGCGACCGCATGGCGTTCCGCAGCGCGTCCTACTGGGACATCGTGGCCCAGCTCGATGCGAGCGTGTCCGACCCGCAAGCCTCGCCGCCCACCTTCACCGCCCGCCTGACCGGCGTCGACGGCCTGCGCGTGGCCGCCGGCCGCGACTTCGACTCGCTGGGGCAATTGCGTAAGGCCGACGAGGTGACCGTCCTCGACGAGGCGAGTGCGACCCAGCTGGCCGCGGGCCTGCGCGGCGCTCAGCTCAACGTCGCGTCGGTGGAGGAAAAGCCCTACACCCGGCGCCCCTATGCGCCGTTCATGACCTCGACGCTGCAGCAGGAGGCCGGCCGCAAGTTGCGGTTCTCCTCCGAGCGCACGATGAGCATCGCCCAGCGGCTCTACGAAAACGGCTACATCACCTATATGCGTACCGACTCCACCACGCTGTCGGAGTCGGCGATCAACGCTGCGCGTACCCAGGCCCGCCAGCTCTACGGCGCCGAATACGTCTCCCCATCGCCGCGCCAGTACACCCGCAAGGTCAAGAACGCCCAGGAGGCCCACGAGGCGATCCGCCCCGCGGGGGAGACGTTTGCGACCCCGGACGCGGTGCGCCGCGAACTCGACGGCGACGAATTCCGCATCTACGAGTTGATCTGGCAACGCACGGTGGCCTCGCAGATGGCCGATGCCCGCGGCACCACGCTGAGCCTGCGGATCAACGGCCAATCAACGGCGGCCGGGGCCCGAAGAGAAGTCGTGTTCTCGGCCAGCGGTCGCACCATCACGTTCGCGGGCTTCCTGAAGGCCTACGTGGAGACGGTGGACGAGTTGGCCGGCGGCGAGGCCGACGACGCCGAGAGCCGGCTGCCGCAGTTGACCCAGGGCCAGCGGCTGGACGCCATCGAGCTCACGCCCGACGGCCACGCCACCAACCCGCCGGCGCGCTACACCGAGGCGTCGCTGGTCAAGGCGCTCGAGGAGCTGGGCATCGGCCGCCCGTCGACGTACTCGTCGATCATCAAGACCATCCAGGACCGTGGCTATGTGCACAAGAAGGGCAGCGCGCTGGTGCCCTCCTGGGTGGCGTTCGCCGTAACCGGTTTACTGGAACAGCATTTCGGTCGCCTCGTCGACTACGACTTCACCGCCGCGATGGAAGACGAGCTCGACGCGATCGCCTCGGGTCAGGAGCGACGCACCGACTGGCTCAACAACTTCTACTTCGGTGGCGAGCACGGGGTGGCCGACTCGGTGGCCCGCTCCGGTGGTCTGAAGAAACTCGTCGGCGTCAACCTGGAAGGCATCGACGCTCGAGAAGTCAACTCCATCAAGCTCTTTGACGACGAGCAGGGCCGACCGGTCTACGTCCGGGTGGGCAAGAACGGGCCCTACCTGGAACGCATGGTGACCGGCGACGACGGTGAGCCCAAGCCGCAGCGGGCCAACCTCAACGACTCACTGACCCCTGACGAGCTGACGCTGGAGGTGGCCGAGCAACTGTTCGCCACCCCGCAAGAGGGCCGCGTGCTGGGGGTGGACCCGGCAACCGGGCACGAGATCGTCGCCAAGGACGGCAGGTACGGGCCATACGTTTCCGAGGTGCTGCCGGAGCCGCCACCCGGCGACGACGACGGCAGCGCCGCGCCCGCGAAGAAGGGCAAGAAGCCCACCGGTCCCAAACCGCGCACCGGCTCGCTGCTGCGCACCATGGACCTGCAGACCGTCACGCTCGAGGATGCGCTGCGCCTGCTGTCGCTGCCCCGAGTGGTCGGTGTCGACCCCGCCTCCGGTGAGGAGATCACTGCGCAGAACGGCCGCTACGGCCCATACCTGAAGCGCGGCACCGATTCTCGGTCACTGGCGACCGAGGAGCAGATGTTCGACATCACCCTCGAGGAAGCGCTGAAGATCTACGCCGAGCCCAAACGCCGGGGCCGGCAGGGCGCCGCCGCGCCGCCGCTGCGTGAGCTGGGCATCGATCCGGCGACGGGCAAGCCGATGGTGATCAAGGACGGCCGGTTCGGCCCCTACGTCACCGACGGTGAGACGAACGCCAGCCTGCGTAAGGGCGACGACGTGGCCTCGATCACCGACGAGCGCGCCGCCGAACTGTTGGCCGACCGCCGGGCGCGTGGTCCGGCGAAGCGTCCCGCCAAGAAGGCCGCCCGCAAGGCGCCGGCCAGGAAGACGGCGGCGAAAAAGGCCGCCAAGCGGAGCTAGCCGGGTTCAGTAGCCGGGGCCGATGGACTCGCCGGACATCTCTTCGGCCCGCGCCTGGTTGGGCTGCGAATCGGTGGTTCCGGCCAGGTGCACCGGGCGGGCCAGCTGGGTCGGCGCTCGGCGGCCGCGCAGCTCCACCACCTCGCCGACATCCCAGCACAGGGCTTCGGCGTCGAGCGCGCCGCTGACCGCGATAGCCGACGCGAGCACGTGGCCGGGTTCCAGCTTGGCCAGCTCGGTCAGCCGGGCGGCCTCGTTGACCGGGTCGCCGATCACGGTGTACTCGAAGCGGGCCTGCGCGCCGATGTGGCCGGCGATGGCCCGCCCGGATGACACCCCGATGCCGAACTCCGCCGACCCGATCACCGGCAGCAGCGCGTCGTGCAGTTCCCGGGCGGCGGCCAGCGCCCCGCCGGGCGAGTCGGGGTGTTCGATCGGCGCGCCGAAAATAGCCAGCGCGGCGTCACCCTGGAACTTGTTGACGAAACCACCATGCTTGCCGACCGTGTCCACGACCACCCGGAAGAACTCGTTGAGCAGGTGGACCACCTCGGCGGGCGGCCGGGTCGAGGCAAGCTGCGTGGAGCCGACCAGGTCCACGAACAGCACCGCGACATCGCGCTCCTGGCCGCCCAATTCGGTTCCGCGCTCCAGCGCCCGGCGGGCCACGTCTTCACCGACGTAGCGGCCGAACAGGTCACGCAGCCGCTGCCGCTCGGACAGGTCACGCACCATGTCGTTGAAGCCCGCCTGCAGCAGGCCGAGCTCGCTGGCGTCGTAGATCTGCATGTGCGCGTTGTAGTTTCCGCGCTGCACCTCCGACAGCGCCCAGCGCAGCTGGCGCAGCGGATCGGCGATCGACATGGCCACCAGCAGCGTGCTGATCAGACCGATACCCAGCGCCGCCACCGCCAGCAACAGGATCGGGGTGAACAACTTCTCCGGCGTGGCATGCAGCAGCGAGGTCTTGTCGGCCACTACCGCCAGCACGATCGCCAGCACCGGCACGGCGGTGGACAGCATCCAGGTCAGGATCTGCCGCAGGATGACGCCGGGCGCCTTGACGTTCTCGGGCACCCCGCTGCGCAGGGCGGCCACCGCCACCGGCCGCAGCACCCGCTCGGACTGCAGGTAGCCGATGATCGAGGTGGCCGCGGCGCCGAGCCCGGTGGCCACCGCCACCACGGGCGCGGCGAAGCGGGCCACCGACCAGCTGGCGATGATGAACACCACGCTGCCGATGGCCCAGGCCACGATGCTGATCAGGGTGCGGTAGAACGGCATTCGCAACGCGCGGCTGCGGGCCAGTTCGGTGGCGGCCGGGTCGGCCTCGGCGAGCATGTTGTCGCGGCGCTGCCACCGGAATACCGGCATCAGCAGCCGCAGTGTCACGGCCAAACCGGTGAGGAACACGACGACCAGCGCGGTGGCGAAGATCGCCAGGTTCAGGACCGGTAGGTCCTGCAACTGGATGCGGTCCTCGGGCGGCAGGGCGTAGCGAAGGAAGCCGAGCACGAAGAGCGCGCCGATGATGTCGGCCTGCAGCATGCTGAGCGAGAACAACGGCCACGGCGTGCGCATCACCCAGCGGACGAATGCGCTGATCCGCCCCGGTAGTGCCGCCGCCGTTGTCACTAACCCACCGTATCGGTCGGCAGTGACGTCTCGGAAACTTAATATCGATCTCGGCAGGTCGCTCAGGGCGCGTCGAGCGCGCCGAAGATAACGGAATGGTCGCGGTACGGTGGCCGTTCGGTATCTGTCGGCGGCGCCACTACTGTTACCGGTGATGTCCGGGGTGTTTACGCGGCTGGTAGGCCAGGACGCGGTGACGGCCGAGCTGCTGGCCGCCGCCAGAGCCGCCCGTGGTGACTCAGGCCACAGCGGGGCCGGCGCCGGGACTATGACACATGCATGGCTGATCACAGGGCCTCCGGGTTCGGGCCGCTCGGTGGCGGCGTTGTGCTTCGCCGCCGCCTTGCAGTGCACGTCCGACGGAGAGCCGGGCTGCGGACGCTGCCACGCGTGCACGACGACCATGGGCGGCACCCACGCCGACGTGCGGCGCGTGATTCCCGAAGGCCTGTCCATCGGTGTCGACGAGATGCGTTCGATCGTCCAGATCGCGTCGCGGCGCCCGGCCACCGGGCACCGGCAGATCGTGGTGATCGAAGATGCCGACCGGCTGACCGAGGGCGCCGCCAATGCGCTGCTGAAGGTGGTGGAGGAACCGCCGCCGTCGACGGTGTTCCTGCTGTGCGCGCCGTCGGTGGACCCCGAGGACATCGCCATCACGTTGCGGTCGCGGTGCCGGCACGTGGCGTTGGTGACCCCGCCGACCGAGGCGATCGCACGCGTGCTGGTCGACAGCGACGGCCTGACCCCCGACACGGCGAACTGGGCCGCGTCGGTCAGCGGCGGCCATGTGGGCCGGGCCCGGCGGCTGGCGACCGACCCCGAGGCCCGGTCGCGCCGGGAGCGGTCGCTGACGCTGGTGCGCGACGCCGCGACCCCGTCGCGGGCCTACGCCGCCGCCGAGGAGCTGGTGGCCGCGGCCGAAGCCGAGGCCGTGGTGCTGACCGCGGACCGCGCCGAGGCCGAGACCGAAGAGCTGCGCACGGCCCTGGGCGCCGGCGGCACCGGCAAGGGCACCGCGGGCGCGATGCGCGGCGCGGCCGGGGCGATGAAGGACCTTGAGCGACGGCAGAAGTCGCGTCAGACACGGGCCTCGCGCGACGCGCTGGACCGCGCGCTGATCGACTTGGCGACGTATTTCCGGGACGCGCTGATGGTCTCCGCGAATGCCGGGGCGGTGCGGGCCAACCATCCCGATATGGCCGAGCGGGTCGCGGCGCTGGCCGCCCACGCCCCACCCGCGCGGCTGCTGCGCTGCATCGAGGCGGTGCTTGAGTGCCGCGAGGCGCTGGCGATCAACGTCAAGCCGAAGTTCGCCGTCGACGCCATGGTCGCCACCATCGGCCAGGAACTGCGCGATTGATCGCCCGGCGACGATGCAGACGGCGTTGCCGTGTGAGGAGGAGCGGGCGCAATCCTGATTTCGTGGTGTCGGGCCGCCTGCCGTAGACTCGTGCCGCCCGGCGTGCGGGTATGCCGCCTTAGCTCAGTCGGTAGAGCGATTCACTCGTAATGAATAGGTCGGGGGTTCGATTCCCCCAGGCGGCTCCATAGTTTTAGGCGGACGCGACGAACCCCACCGGGCCCGATGCGAGGCACAACGCCAGCGCGGTGGTATTGGCCCGCACGGTGATCGCGTCCCCGGCACCCGGTAACCGGGCATAGACCCGGTTGAGCCCGGGATGCACCGGCACCTTGACCTCGGGTCCTTGCGTCATCGACAACGTCATCGAACCGTCGCTGTTGGCCAGGTAGTTCAGCTCGACGGTCCAGTCGGCGGGCAGCAGCGGGCCGTCGAGGACCAGGCGCGCCGGATTGTCCGGCTGGGCGAAGTAGCCGCACCGCGGAATCGGCCCGGGCGCGATGGTCCGTACCCAGGTGACGCGCGCCTTGACCAGCCGGCCCGAGTTGTCGAACATGCGCAATTGCGTTGTCGCAGGCGCGAATTCGGGTCGATCCCGCAGCAGGGCGAACAGGTGACTGGCCAGGTTCTCCGGGGCGGCCACCCGTTGCAGCACGAACGGGTCGACCTCCTGATCCAGCAGCGGCGCATCCGAGGCCGTGTGGGCCTCGGCCAGGGCGGCCCGGGCGTTCTGCAGATAGGGCTGGGCGGGGTTGTCGCGCCAGCTGGTCAAGAACGTGGCCGTCGAATACAGGCTGCTGGCCGCGAACAGCACTGCCACACCCGCGGTCACCGCGGTGCGTTTCGGCGAAGCGTCCAGCCATTGCGGGCCGGCCCGCCGATTGGGGGCGCTCAGTGCCACGGCGGCCAGCAGCGCCAGCACCACGACGAGATCGGGCAGGTAGCGTAGGGTCTGCGCGAGCTCCAGTGCGGTCTGGTTCGACGACCGCATCAGATAGATCGGCACCTGGCAGGCCACGGCATAGCCGACGGTGACGAGCCACACCGGCCCGATGCGCTCCTTGCGAACCAGTGACACCGCCAGGATCCCGACCAGCACGAGCCAGCCCAGCGCCATCACCGCCGGCGGGGGCGTCGCCCAGGGGGAGGCCGGCGCCCACCGGTCCCAGTGCCACGGCCCGCCCGCCAGACCCGGCACGATGCCGTGCGTGATCGAGCGCACCAGCAGCCGGCATGTCATCGCCAGGTCGGAACTCCACCGCTGCTGATTGACCACCGCCAGATACAGCGCGATCCAGGCGGCGGTCAGGGCTAGGGCGCCGATCCACAATCGCAGGCCGGCCCGCCACACCGTCGCCAGCGACGACCCCAGGCTCCGATCGCCGGTCACGTGGCTCAGCAGCGCGGCCACCGCGAACGCGACGAACGGGATCACCGCGGCCTTCTCGAAGAACAGCAGCCCGCCGAAGTAGACCAGCACCCCGGTCACCGCGTAGCGACGTTTGCCGGTGCGCACCAGCAGGATGGCGTCGGCGCACACCCAGGCCAGCGCGGCCAGCATAGGCAGCGAGTTCAGCGCCGCCGCCCACCACGCGAAGCCGGGCACCCCCAACGGCGTGAACAACGCGAACGTGAACGGGATCAGCAGCACCGGCCGCCAGCCGAGGATGACGTACAGCGCGCGCAACAAGGCCAGCGACGCCAGCAGTTGCAGCACCAGCAGGCTGACCGCCGGCCAAGTCCAGTCCAGTGGCGCCAGCCGGATGATGGTGCCCGCGACCAAAAATGCCCCGGGCATGACGTGCCCGTCGTGGTCGTCGAACAGATACGACGGCGCGAGCAGGTTGTGGGTGCCGGCCTTGCCGATGAGGATCAGGTCGTCCCAATAGAAGTAGCCACCGAACGCCAGCACCCCGCGCACCGCCAGCTGCACCGCGATGAGCGCGGCGGCCGCGACCGCTATGTATGGTGGGCCGGTGCGCGCACTGGTCACCGGGGCAGCCGGATTCATCGGCTCGACGCTAGTCGACCGTCTGTTAGCCGACGGTCATGCGGTGGTGGGGCTGGACAACTTCGCGTCGGGCCGCGCGACCAACCTCGAGCATCTGGCCGACAATCCGGCGCATGTCTTCGTCGAGGCCGACATCGTGACCGCGGACCTGGAGGCCATCCTCGACGAGCACCGCCCGGAGGTGGTGTTCCACTTGGCCGCCCAGATCGACGTGCGGCACTCGGTGGCCGACCCGCAGTTCGACGCTTCGGTCAACGTCATCGGCACGGTGCGCTTGGCCGAGGCGGCCCGCAAGGCGCAGGTCCGCAAGATCGTGCACACCTCCTCGGGCGGATCCATCTACGGCACCCCACCGCGGTACCCCACGCCCGAGACCGTGCCGACCGACCCCGCGTCGCCGTATGCGGCGGGCAAGGTGGCGGGCGAGATCTACCTGAACACCTTCCGCCACCTGTACGGGCTGGACTGCTCGCACATCGCTCCGGCGAATGTCTATGGCCCCCGTCAGGACCCGCATGGTGAGGCCGGGGTAGTGGCGATCTTCGCCCGCGCCCTGCTCTCGGGCAAGCCCACCAAGGTATTCGGGGACGGCGGCAACACCCGCGACTACGTCTTCGTCGACGACGTCGTGGACGCCTTCGTCAAGGCATCCGGTGACGACGGCGGCGGGCAGCGTTTCAACATCGGCACCGGAATCGAAACCTCGGACCGCCAACTGCATTCGGCCGTGGCCGCCGCGGTCGGGGGACCCGACGACCCGGAGTTTGCGCCGCCGCGGTTGGGCGACCTCAAACGTTCCTGCCTCGACATCGGTTTGGCCGCAGAGGTTTTGGGCTGGAAGCCCAGGGTTGAACTCAGTGACGGGGTGGCCCGCACGGTGGAATACTTCCGTCAGGCGCAGGCCGGCTGACCGGGCGTCGAGATCGACGTCAGCGTGCGGCCTACTCGAACCTTCCCGCGCCAGCGTCGATTTCGGTGACGGGCGCCTGTGCGGATTCCATCGCCACCGCCCGGGCCAGTCTCGCGTAGCGCAGCTCCAGATCCTTGAACCGCATGTAGGTGCTCAGCGTGGTGAAACAGAACGCCATGATCAGCGCGTAGAGCATCAGGTCGGTGCCGCGGCGCACCCCGAACCACTGCGCCACCACCGTGGTGTCGTCGGGCCGCAGCACGGCATAGATACCGCCCAGCACGAACACCACGTAGCCGACCTTGACCCAGGCCCGGGATCGCGCGTTGCGGCGCGACCGCAGCAGATACACCAGTAGCGCGACTATCGATCCGATCAGCAGTACCTGAATCCAGTTCATATTCCAACCCTTTTCATCTCGGAATCCGCCCTCGCAGGAATCCGTCGAAAATGATGTTGACGCCGTTGAGCAGGGGTTGCCCCTTCGACCTCGAGTACGCGGTGTAGAGCACCTCGATGGGTTCTTCGGCGACGCGCCAATGGTTTTCGTCGATCAACATGATGAACTCGTTGGCGTGGCTCATGCCGCTCATGGTGATGTCCAGCCCGTCGGCGACCTTCTTGTTGAACACCCGCAGCCCATTGTTGGTGTCGGTCAGGCCGAGTCGGCGGCCGCGCCGGCTCAACCGCGCGGCGGTCTGCAACACGATCCGTTTCACGAACGGTGGCCGGGCACCGTGCTGTGCGCCGAAGCGGGTGCCGATCACCACGTCGACGTCGCCGGCGCGCAACCGGTCGACCATCGTCACCAGGTCTTTGACGCGGTGCTGCCCGTCGGCGTCGAACGTGGCGAAAACCTCGGCCCCGGGCTGCTTGCGGGCGTACTCCACGCCGGTCTGGATGGCCGCGCCCTGCCCGAGGTTGATCGGATGCCGCACCAGGTGAGCCCCGGCCCGCCGGGCGATCTCCCCGGTGTCGTCGGCGCTGCCGTCGTCCACGCAGACGACATGGTCGAACACCGAGCGCACATCGGCGACCACCTCACCGATGACAGCTGCTTCGTTGAAGGCGGGAATGACGACCCAGACGACCGAATAATGCGTTTCAGTACCCATCTAAGCCCACAAGGTACACGCCTGTGCAGGTCATATCAGCCGGTAGAGCGCGTGGCGCGGGACAGCGCGAGCAGATGGACGCCGATCCCCACGACCGGGCCGCACAGCAACCCGACCACGGTCCGGGTCTGCAGGGACAGCGGCAACAGCAGCAGCAATCCCGACGCGACCGTGGCGCTCACCCAACCCAGCGAGTAGGCCCGGTGCAGCGCCGCGGCCACCGCCGCGGCGCCGGTCAGCGTCAGCATCGCGATCGCCACCGCGGCCGCGGTCAGCCACGCCAACAGCGCGCTGCTGGCGTGGTACTGCGGCCCGAAGGCGACCCGCAACAGCCACGGGCCTATCACGCCCGCGGCCAGCACGCCGACCGCGCCGATCGCCCCGACGATGCCCGCCGGGGCGAGCAGCGCGCGAATCCGATTGCTGCGCTCGTCGACAAAATGAGCAATCAGGTTGCCCTGCATGGCCGTCAGCGGCACCAGCAGCGGCGCGCGGGTCAGCGTGACGGCCAGGATGATCACCCCGCCCTGTGCGCCGAGCTCGGCGCTGGTCAGCTTCAACAGCACCGGAAATCCCATCACCAGTATGGCGCTGGCACCGGCCGCGGTGATCGAATGCGCCGCGCCCCGCAGGAAGGTCGCGGTCCCGCCCGGGGTCAGCAGGCGGGCAGTCGCCCGGGTCGCCGGCGAGGCCACCAGCAGGATCAGCCAGGCGACCGCGCCCGCCACCGTCGCCCACAGAAATCCGACCAGGCGCCAGCCGAGCGTGACGGTCGCCGCGGCCACCGTCACCCGGATGACGGCGTCGGTCACCATCAGCGCGCCGTAGCGGGTCCACTGGTTGGTGCCTGCCAGCATGCCCAGCAGGGTGGCGTGCAGGCAGAAGCCGGCCAGCCCGACGCTGAGCAGAACCACCGACAACAGGCGCGCCTCGACGAACACCCGCCCGCTCCACAACGGCGAGCTGCCCGCGATCAGCACGGCCGCGGCCACCCCGACCAGCATGGCGACGCGCATCGGGTGGGTACGCGGCTCGCCGGGCACCGGCAGCGCGGCCAGGTCGCTGATGTAAGGCGTCGAGCGGACTTCCCGGGTGGTTTCCTGCAGCAGGCCGTTGGCCGCGCCGGTGACCAGACCGAAGGCCCCCCAGAACACCCCGAATACCGAAAAGCCGCTCGGCGCCAGGTCACGAGCGGCCAGGTAGATGACGGCGTAGCCACACAGCGCCGTCACGGCGGTGGCGGTGCCGACCCGGGCCATGCTGCCGCGCGCCACCGGCCCCTGTGAGGCACTGATCTCGGTCATCGGGGCGGCGACGCTTTCGGCCCGCTTCCCCGATGTATCGCCACAATTTGAAAATTCTATGCGGCCCGCGGCGGGCGTCCCCGGCGGCGACGCGGTTCGCTAGTGTGAGCTGGCCGTCGGGAAGGATCCATGTCCGCTTTGCGTACCTTCGCGATCTCGCTCGTGGTCACCGCGGCGGCGCTCGCCCTCGGATATTCCTACGGCGGTTTCAAAGACCTCTATCTGTTGGTGGTGCTGGCCGCCCTCGAGGTGTCGTTGTCGTTCGACAACGCCATCATCAACGCGGCGGTCCTGAAACGGATGAGCCGGTTCTGGCAGCGGATGTTCCTGACCATCGGGATCCTCGTCGCCGTGTTCGGCATGCGGTTGCTCTTTCCGCTGCTCATCGTGTGGGCGACCGCGGGCCTCGACCCGGTGCGGGCGATGGAGCTGGCGCTGCATCCGCCGCCGCACGGCGCGCTGGAGTTTCCCGACGGCTCGCCCAGCTACGAAAAGCTCGTCATCGTGGCCCACCCCCAGATCGCGGCGTTCGGGGGGATCTTCCTCTTGATGCTGTTTCTAGATTTCGTTTTCTATGACCGAGACATCAAGTGGCTCAAGTGGATTGAGATCCCGTTCGCCCGCATCGGCCGGCTGGGGCAGGTGTCGCTGGTGGTGACTGGTGTGGTGCTGGTCCTGGTGGGCACGCGGTTGACGCACTCGGCCGACGAGGCAGCCACGGTGCTGACCGCCGGACTGCTGGGCTTGGTCACCTATCTCGTGGTCAACGGATTGAGCCGGGCGTTTCGGCCATCCGACACCGAAGCCGACGTCGAATCCGGAGCCGGCGCGGCGACCGGCTGGGCCGGCCTGACCCTGTTCCTCTATCTCGAAGTTCTCGACGCCGCGTTCTCGTTCGACGGCGTCACCGGCGCGTTCGCCATCACCTCGGACCCCATCGTGATCGCGCTGGGGCTGGGGCTGGTGGGTTCGATGTTCGTCCGGTCCATCACCATCTACCTGGTCCGCCAGGACGCGCTGGGCCGGTACGTGTATCTGGAACACGGGGCGCACTGGGCGATCGGGGCGCTGGCCGTGATCATGCTGTTCTCCATCGAGCCGCGATTCGACGTTCCCGAGCCGGTCACCGCCTCGGTCGGGGTGGTGTTCATCGCGGCGGCGCTGGGCTGGAGCGTCCTGCGCAACCGCCGCGACGCGCGCCGGGGCGTGACACGACCTCGCTAGGCCTCGATCTGCCCGGCGATGCGCCGTTCGATCGCGGCCCGGGCGGGCGCGGGAAGCACGATCAGGCCGTCGAGCTCTTTGGTCGCCCGCGCGTAGGCGTTCTGGCGTTCCTCACGCGTGGCCGCATCGTCGTGCGCCAAGTGCAGCAGGTGCTGGGCGCGCGCCAGCCGCTGCTGATCGTCCGCCGAGAAGTCGCTGCGTCGCCGGCGGATCGCCTCGGCCTCGGCGATCTCGAACGCGTTGAGGTACTCGTGGACGGCATCGCGGTAGTCCAGTAGCGCATCCCGGTTGCCCACCAGGGCGTCGGGCGGTTCCGGCCGCAGCAGATCGGCGTGCCGCTTCGCCTTGTGGAAGGCGATGGTGAGCGGGTCGCGCATGTTCGTCATCATCGGGAAGTCCAGCAGCTTGGCGATGTCGACTTCGTAGTCGAACCACCGGGCGTCGGTACGGTCATGCGCGGCAACGAGCTTGGTGAGTTCTCGGCGGTCGTGTTCCTCGTTGGCCCGCCCGCGCCCGGTTGCCTCGGCCACCGCGATCTTGGCCTGCTGCTTCAACCGGTACCGCTCCATCCGGCGCTCGGCGCGACGCTCGTTGGCCGCGGCGATGGCCCGAAGGCCGCCGCCGATCGCACCGCCCAGCGGAAACACCAACCACCAGAAATTGGCGGCGAAATGCAGCACCGGGTTCACATCGCCAGGATGCCACCGAGAATCCCGCGGCGGCGCCGGCGCGGTTACACCCTAAGCGTCAGTGCCCCTGGGCCTTGAACCGCTCGATCGAACGCTGGATCTCCGCCTCGGCCTCGTCGCGGCCGACCCAGTCCGCGGCCTTGACGAACTTGCCCGGTTCCAGGTCCTTGTAGTGAACGAAGAAGTGCTTGATCACGTCTAGCTCGAACTCCGGGACGTCCCCGATGTCCTGGACGTGGTCCCAGCGGTGGTCGCCGGCCGGCACGCACAGGACCTTGTCGTCGCCGCCCTTTTCGTCGGTCATCCGGAACATGCCCACCGGACGGGCCTCCACGATCACGCCGGGAAACACCGATTGCGGCAATAGCACCATCGCGTCCAGTGGGTCGCCGTCCTCGCCGAGCGTGTCCTCGATGAAGCCGTAGTCGGTCGGGTAGGCCATCGCGGTGTACAGGTAGCGGTCCAGACGCAGCCGCCCGGTCTCGTGGTCGACCTCGTACTTGTTCCGCTGGCCCTTTTGGATCTCGATGGTCACGTCGAATTCCACCGCGTCGGCTCCTTGTCTGTTGAGGAAGGCGCTGTTTGGGCAGGCCAATTTTGCTCTGCTACACCCTAGTCGAGGGCATCGCCGCCGATTCGGCAGAATGGGCTGGAGACAGTCAGGAGAGTGATGGCCGGTACTCGCTGGCAAAAATCCACCCCCGTGTTCATCGGGTTGGGCGTGCTGGCGTTTGTCGCCGCGGTAGTGGTGGCGGCAACGTTTTTCACCACGAGCGGCCACGGCGCCAACAGCGCGCATGCCCCGATCCCGCCCCCGCACGCCCCGACCGTGAAGCCGGGGATGGTCCCGGTGAGCGATACCGCCGAGCTACCCAGCGGACCCGGCGTCGGCGCGATGCTGGCGGCGGTGGCGGGCGACCCCAACCTGGGCCGGTTGGGCGGTCGGGTCACCGACGCCATCACCGGGAAAGAGCTGTGGCAGGTGGCGGACGACATGCCGCTGGTGCCGGCGTCGACCAACAAGGTGCTCACGGCGGCCGCGGCGTTGCTGACCCTGGACCGTCAGGCCCGGATCAGCACGCGCGTGGTGGCCGGCAGCCAGAACGCCCAGGGACCCGTCGTGCTGGTCGGGGCGGGGGATCCGGCGCTGTCGGCGGCGCCGCCCGGCGTGGACACCTGGTACCGGGGGTCGGCGCGGATCAGCGATCTCGTCGAACAGATCCGCCGCAGCGGCGTGACGCCCACCGGGGTGCAGGTGGACACCTCGGCGTTCAGCGGGCCGACGATCGCGCAGGGCTGGGACCTGGCCGACATCGACAACGGCGACATCGCGCCGATCGAATCGGTGATGATCGACGCCGGCCGCATCCAGCCCAGCACGGTCAACTCGCGGCGGTCCCACACCCCGGCGCTGGACGCCGGCCGGGAGCTGGCCAAGGCGCTGGGCCTGGACCCGAACGCGGTGACGATCGCCAACGCCCCGTCGGGGGCCCGGCAGCTGGCGGTCGTGCAGTCGGCGCCCTTGGTCCAGCGGCTGTCCGAGATGATGGACCACTCCGACAACGTGCTGGCCGAAAGCATCGCCCGCGAGGTGGCGGCCGCGATCAACCGGCCGCGCAGCTTCGCCGGCGCCGCCGACGCGGTGAGCAACCGGTTGACCACCGCCCACGTCGACACCGCGGGGGTGGCGCTGCTGGATTCCAGTGGGCTCTCGGTCGACGACCGGCTGACCGCCAAGACGCTTGACGGCGTGCTGCAGGCCGCGGCGGGGCCCGACCAGCCGTCGCTGCGGGCGCTGCTGGATCTGCTCCCGATCGCCGCCGGCAGCGGGACGCTGGCCGACCGCTTCACCGACGCCTCGACGGCCCAGGGCCCCGCCGGCTGGTTGCGGGCCAAAACCGGCTCGCTGACCGGCATCAACGCCCTGGCGGGGGTGCTCACCGACCGTAGCGGCCGGGTGCTCACCTTCGCGTTCCTGTCCAACAACGCCGGGCCGAACGGCCGGAACGTGATGGACGCGCTGGCGACCCGGCTGTGGTCCTGCGGGTGCTCATGACGTCGACGCCGGACCTGACGCTCGGTACCGCCGTCGACTGGCAGTTCGCGGCCACGGTCGGTCGGCGGCTCGCTCGGCCGGGACCGCCGTCCAGCGAGTACACCCAGCGCCAGGTGATCGACGAGCTGGCCAGTGCCTCGACCAAAGCCGAGCCGTTGGTGCGCGACGTCACCGGCCTGGTCACCGACGGCGCGGTGCCGGCCGCCCGCATCGTTGACCGCCCGGATTGGATCGGCGCGGCCACCGAGTCGATGCGGGTGATGATGAACGGCGCCGAGAAGCCGCGCGGATTTCTCACCGGTCGCGTCACCGGGGCGCAGACGGGCGCGGTCCTGGCCTACGTGTCAGCGGCGATTCTCGGCCAGTACGACCCGTTCGCCACTGCCAACGGCGCCAAGACGGGCTGCCTGCTGCTGGTGTATCCGAATGTCATCGCCGTCGAGCGGCAGCTTCGGGTCGAGCCGTCGGATTTCCGGCTGTGGGTGTGCCTGCACGAGGTCACCCATCGCGTGCAGTTCACCGCCAACCCGTGGCTGCCCGGCTACATGTCGCAGGCGCTGGGCCTGTTGACCCGCGACACCGGTGAGGACATGGGACAGGTGATCGGCCGGCTCGCCGAATACGCGCGCAACCGCGGGGGGCCGGAACCCGACGCCAACAGCTCGGGGATTCTCGGTCTGGTGCGCGCGGTGCAGTCCGAACCGCAGCGACGGGCGCTGGACCAACTGCTGGTGCTGGGCACCCTGCTGGAGGGCCACGCCGACCACGTCATGGACGCCGTCGGGCCGATAGCGGTGCCGTCGGTGGCCACCATCCGCCGCCGGTTCGACGAGCGCCGCCACCGCAAGCAGCCGCCGGTGCAGCGGTTGTTGCGCGCGCTGCTTGGGCTCGACGCCAAGCTCAGCCAATACACCCGCGGCAAGGCGTTCGTCGACCACGTGGTCGGCCAAGTGGGCATGGCGCGGTTCAACGCCATCTGGACGGGCCCCGAAACGCTGCCGCTGCCCAGCGAGATCGAAGAACCCCAGCGATGGATCGACAGGGTGCTGTAG

Protein sequences of DBSCAN-SWA_1

>NZ_AP022590|5031869:5089629|5045043_5045424_-|WP_083100117.1|DBSCAN-SWA
MSWLLVAGVPALLMLAALGLGRIESELAPDTLAVADVDEFLERAGGVDMHTLASEGMPEALEYLHRREIQQLAEAPANGRGGGPRHAAPSFAIGFVDRDELTLPTRIHGHSHVNPQFKAPRHANRV
>NZ_AP022590|5031869:5089629|5066240_5067041_+|WP_083098958.1|DBSCAN-SWA
MNGPLAGALLLSLALVVVRPSPRRRLSASRRRRFSPATGARGAACVAAGIGCATAIALPLTAVLCVAVVGATVGLRYRRRRRIRRAATEGHALHTALEVLVGELRAGSHPVRAFCVAADDTGGAVAVSLRSVAARARLGADVAAGLAAAGRSSALPTHWERLALCWRLASDNGLGIATLMRAAQRDIAARQRFSAQVSSSMAGARATAAILAALPLLGVLLGQLIGARPLGFLLSGHAGGWLLLIGSTLACVGLLWSDRIADRVAS
>NZ_AP022590|5031869:5089629|5078059_5079268_+|WP_083098971.1|DBSCAN-SWA
MSGVFTRLVGQDAVTAELLAAARAARGDSGHSGAGAGTMTHAWLITGPPGSGRSVAALCFAAALQCTSDGEPGCGRCHACTTTMGGTHADVRRVIPEGLSIGVDEMRSIVQIASRRPATGHRQIVVIEDADRLTEGAANALLKVVEEPPPSTVFLLCAPSVDPEDIAITLRSRCRHVALVTPPTEAIARVLVDSDGLTPDTANWAASVSGGHVGRARRLATDPEARSRRERSLTLVRDAATPSRAYAAAEELVAAAEAEAVVLTADRAEAETEELRTALGAGGTGKGTAGAMRGAAGAMKDLERRQKSRQTRASRDALDRALIDLATYFRDALMVSANAGAVRANHPDMAERVAALAAHAPPARLLRCIEAVLECREALAINVKPKFAVDAMVATIGQELRD
>NZ_AP022590|5031869:5089629|5058937_5059801_+|WP_083098948.1|DBSCAN-SWA
MPEHSGFWGETWRKLHRRPKFVVAGVLIVLILLVALFPALFTHADPGYADPGQSLRGPSAAHWFGTDLQGHDIYTRTIYGARASVTVGLGATLLVFVVGGMWGALAGFYGGWLDAVVSRVADIFFGLPLLLAAIVLMQVLHHRTVWTVIAILAIFGWPQIARIARGAVLEVRGSDYVLAAKALGMSRFQTLLRHALPNAVGPVIAMSTIALGAFIVTEATLSYLGVGLPPSVVSWGGDINLAQTRLRAGSPILFYPAGALATTVLAFMMMGDALRDALDPASRAWRA
>NZ_AP022590|5031869:5089629|5050399_5051359_-|WP_083098931.1|DBSCAN-SWA
MAPPDPSVTRIDGPWRHLDVHANGIRFHVVEALGDVDGPPPTARPLVMLLHGFGSFWWSWRHQLRGLRGARVVAVDLRGYGGSDKPPRGYDGWTMAGDTAGLIRALGHSTATLVGHADGGLGCWATALLHPRLVSAIALISSPHPAALRRSTLTRRDQGYALLPTLLQYQIPLWPERLLTRDDAAEIERLVRSRSCGKWLASEDFSEAISYLRTAIQIPAAAHSALEYQRWAVRSQLRDEGRRFMRSMSQQLSVPLLHLRGEADPYVLADPVDRTQRYAPQGRYVSIAGAGHFSHEEAPEEINRHLTKFLEQVHLTRAR
>NZ_AP022590|5031869:5089629|5048821_5050115_+|WP_163650845.1|transposase|DBSCAN-SWA
MPSKYDPQTRAKAVRLVLEHRADYPSEWAAITAVSKRLGMTAETLRSWIRQQQVDDGDRDGVSSAAAAEIRALKRRNAELEQTIEILKAATFFLRAGERPAQPPLTSSVCEFIAKHRHRFGVAPICRVLTEHGVPIAPRTFYAWVKRAPSKRALWDATISEVLAGYYEPDEHGRRKPESLYGSVKMWAHLQRKGIPVAKSTVERLMRRNGWQGVRRQKAVRTTIADPAAVRPPDLVDRQFGVGAPNQLLVADFTYVKLVTGVFVYVAFVIDAYAGAIVGWEACASKQTQFVESAIRQAVALRSRQGHPIEDAIHHSDAGSQYTSVRFGETLALSGIRPSVGSVGDAYDNALAETTIGLYKTECIRPDSPFRRGPLTTVGDVEYITADYVAWYNQQRLMHRLGRVPPAEAEAQYYSQHVTDQPAGSQNPEGA
>NZ_AP022590|5031869:5089629|5052177_5052876_+|WP_142275755.1|protease|DBSCAN-SWA
MRRAHRCFLVAMVALLVTAMGSLARAAAADVRIPIGGGAGIVINGDTMCTLTTIGGDAAGELIGFTSAHCGGPGAQVAAEGAENAGVLGTMVAGNDNLDYAVIKFDPAKVTPVANFNGFLISGIGPEPAFGEIACKQGRTTGNSCGVTWGPGQNPGTIVMQVCGQPGDSGAPVTVNNQLVGMIHGAFSDNLPTCVIKYIPLHTPAVVVSFNAVLADINTKHRPGAGFSPLPG
>NZ_AP022590|5031869:5089629|5056377_5058015_+|WP_083098944.1|DBSCAN-SWA
MRRMRTPVALLAPVAAAMLMVASLAGCGGGVLSPDLVVVNGGEPPNPLIPTGTNDSLGGRILDRLFAGLMSYDAAGNPSPEVAQSVDTTDNVNYRITLKPGWTFTDGSPVTAHSFVDAWNFGALSTNAQLQQSFFSPIDGFEAVAGLTGGGKPTATTMSGLQVINDREFTVRLKAPTIDFTLRLGHSAFYPLPQAAFRDMNAFGQHPIGNGPYTLADGPDGPAWEHNVRIDLRPNPNYHGNRKPHNKGLRFEFYSNLDTAYADLLSGNLDVLDTIPSSALTVFQRDLGGNAASGPVAVSQSLDTPLRLPHFGGEEGRLRRSALSAAINRPQICQQIFNNTRSPARDFTASSLPGFDPNIVGSDALDFNPERARQLWTQANAISPWSGRYAIAYNADSGHQEWVDAVANSIKNVLGIDAVGAPQPTFAGFRTQITNRTIDTAFRAGWIGDYPSMIEFLAPLYATGAGSNDVGYSSHEFDAGLAAAEAAPDLRQADVLVNVAQRILLHDMPAVPLWYYIAVIGWSPQVGAVKVTWNGLPDYENLVKG
>NZ_AP022590|5031869:5089629|5046326_5046983_+|WP_083100121.1|DBSCAN-SWA
MPTLTRKARWHIAILAVVATLIAALVAQLRDDSSTTGSPASGRPAAGRDHRDADTPAALAGPRQRANLPPCPGAGSGPGPEALRGVTADCAADGSVVDVARAVAGRRVVLNLWAYWCAPCAAELPAMAEYQRRAGSDVTVVTVHQDENETAALLRLAELGVRLPTLQDGRRRVAAALRVANVMPATVVLRPDGSVAQTLPRAFNTADEIAAAIGNDRG
>NZ_AP022590|5031869:5089629|5051359_5051902_-|WP_083098936.1|holin|DBSCAN-SWA
MSKADGKNGVPSTLTTIPLTDPHAKPAEPSIGDLIKDATTQVSTLVRAEVELARAEITRDVKKGLTGSVFFIAALVVLFYSTFFFFFFVAELLDTWLWRWVAYLIVFGIMVVVGALLALLGFLKVRRIRGPRQTIESVKETRTALTPGHVKAPGPAAQLPEHHGRHAKPGNGGAADPSGW
>NZ_AP022590|5031869:5089629|5047012_5047825_+|WP_083100123.1|DBSCAN-SWA
MSAGGSPLRNGDPAPARGTVPLRPDASPPWLRPLVDNVDDVPDAARRRLPADVLAMITGTAASAVTTLRGGGREAAVLVLFSGPQSGPPDGGIPNDADLLVTVRASTLRHHAGQAAFPGGASDPTDDGPVGTALREAREETGIDVSRLHPLATMERMFIAPSQFHVVPVLAYSPDPGPVAVVNEAETAIVARVPVRAFINPANRLMVYRGDLGRRWAGPAFLLNEMLVWGFTGQVISALLDVAGWAQPWDTTDERELDAAMALVGEGGSR
>NZ_AP022590|5031869:5089629|5034955_5036005_-|WP_142275812.1|DBSCAN-SWA
MIQADARRSADTHLLRYPLPAAWCAGGPDAQVALYLKDETTHITGSLKHRLARSLFLYALCNGWIDEGTTVVEASSGSTAVSEAYFAALLGLPFVAVMPAATSTSKVALIEAHGGRCHFVQSSSEVYAEAERVARETGGHYLDQFTNAERATDWRGNNNIAESIFEQMGDEEHPVPEWIVVGAGTGGTSATIGRYIRYRRHATRLCVVDPENSAFFPAYAEDRDDIVMPTSSRIEGIGRPRVEPSFLPGVVDRMVAVPDAASIAAARHVSAVLGRRVGPSTGTNLWGAFGLLAEMVAEGRSGSVVTLLADSGDRYRDTYFSDEWVAAQGLDPAGPAEALVEFERSCSWK
>NZ_AP022590|5031869:5089629|5085828_5086521_-|WP_083098981.1|DBSCAN-SWA
MNPVLHFAANFWWLVFPLGGAIGGGLRAIAAANERRAERRMERYRLKQQAKIAVAEATGRGRANEEHDRRELTKLVAAHDRTDARWFDYEVDIAKLLDFPMMTNMRDPLTIAFHKAKRHADLLRPEPPDALVGNRDALLDYRDAVHEYLNAFEIAEAEAIRRRRSDFSADDQQRLARAQHLLHLAHDDAATREERQNAYARATKELDGLIVLPAPARAAIERRIAGQIEA
>NZ_AP022590|5031869:5089629|5073444_5076270_+|WP_083098967.1|DBSCAN-SWA
MADPKLKDTSSGGNGSRRRLVIVESPTKARKLAGYLGSRYIVESSRGHIRDLPRAAADVPAKYKSEPWARLGVNVDHDFEPLYIISPEKKSTVTELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPNIPVKRMVFHEITEPAILEAAENPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVQRERDRMAFRSASYWDIVAQLDASVSDPQASPPTFTARLTGVDGLRVAAGRDFDSLGQLRKADEVTVLDEASATQLAAGLRGAQLNVASVEEKPYTRRPYAPFMTSTLQQEAGRKLRFSSERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGAEYVSPSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRIYELIWQRTVASQMADARGTTLSLRINGQSTAAGARREVVFSASGRTITFAGFLKAYVETVDELAGGEADDAESRLPQLTQGQRLDAIELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDAIASGQERRTDWLNNFYFGGEHGVADSVARSGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPVYVRVGKNGPYLERMVTGDDGEPKPQRANLNDSLTPDELTLEVAEQLFATPQEGRVLGVDPATGHEIVAKDGRYGPYVSEVLPEPPPGDDDGSAAPAKKGKKPTGPKPRTGSLLRTMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGTDSRSLATEEQMFDITLEEALKIYAEPKRRGRQGAAAPPLRELGIDPATGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPAKRPAKKAARKAPARKTAAKKAAKRS
>NZ_AP022590|5031869:5089629|5076276_5077905_-|WP_142275756.1|DBSCAN-SWA
MTTAAALPGRISAFVRWVMRTPWPLFSLSMLQADIIGALFVLGFLRYALPPEDRIQLQDLPVLNLAIFATALVVVFLTGLAVTLRLLMPVFRWQRRDNMLAEADPAATELARSRALRMPFYRTLISIVAWAIGSVVFIIASWSVARFAAPVVAVATGLGAAATSIIGYLQSERVLRPVAVAALRSGVPENVKAPGVILRQILTWMLSTAVPVLAIVLAVVADKTSLLHATPEKLFTPILLLAVAALGIGLISTLLVAMSIADPLRQLRWALSEVQRGNYNAHMQIYDASELGLLQAGFNDMVRDLSERQRLRDLFGRYVGEDVARRALERGTELGGQERDVAVLFVDLVGSTQLASTRPPAEVVHLLNEFFRVVVDTVGKHGGFVNKFQGDAALAIFGAPIEHPDSPGGALAAARELHDALLPVIGSAEFGIGVSSGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEPGHVLASAIAVSGALDAEALCWDVGEVVELRGRRAPTQLARPVHLAGTTDSQPNQARAEEMSGESIGPGY
>NZ_AP022590|5031869:5089629|5081244_5082189_+|WP_142275758.1|DBSCAN-SWA
MRALVTGAAGFIGSTLVDRLLADGHAVVGLDNFASGRATNLEHLADNPAHVFVEADIVTADLEAILDEHRPEVVFHLAAQIDVRHSVADPQFDASVNVIGTVRLAEAARKAQVRKIVHTSSGGSIYGTPPRYPTPETVPTDPASPYAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYGPRQDPHGEAGVVAIFARALLSGKPTKVFGDGGNTRDYVFVDDVVDAFVKASGDDGGGQRFNIGTGIETSDRQLHSAVAAAVGGPDDPEFAPPRLGDLKRSCLDIGLAAEVLGWKPRVELSDGVARTVEYFRQAQAG
>NZ_AP022590|5031869:5089629|5082220_5082589_-|WP_083098974.1|DBSCAN-SWA
MNWIQVLLIGSIVALLVYLLRSRRNARSRAWVKVGYVVFVLGGIYAVLRPDDTTVVAQWFGVRRGTDLMLYALIMAFCFTTLSTYMRFKDLELRYARLARAVAMESAQAPVTEIDAGAGRFE
>NZ_AP022590|5031869:5089629|5031869_5033131_-|WP_142275582.1|transposase|DBSCAN-SWA
MSERTSRRYPPELRERAVRMVVEISDQHDSEWAAICEVARLLGVGTAETVRKWVRQAQINAGSRPGTTSEESAELKKLRREVAELRRANAILKTASGFLRGRTRPASALITRFIAEHQGHRDGPDGLRWGVESICAQLTKLGVPVAPSTFYDQVHREPSRRQGRDEVLKREIVRVHTANYGVYGARKVWLALNREGIPVARCTVERLMAELDLAGAVRGKTKKTTIADPTEARPADLVQRRFGPPTPNRLWVADLTYVSTWSGFAYVAFVTDAYARRILGWRVAATMTTSMVLDSIEQSIWTRQQGGVLDLKDVVHHTDRGSQYTPIRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKPGKPWRTIDDVELATARWVHWFNHSRLYQYCGDIPPVELETAYYAQQRRPVAG
>NZ_AP022590|5031869:5089629|5069624_5071964_-|WP_083099018.1|DBSCAN-SWA
MASFGSDLLAAALAGTAPDERPLRHVAELPPRSGRPHEWPAWAEPDIVGAFAGRGITAPWSHQFAAADLAHSGRHVVVSTGTASGKSLAYQLPVLNALATDPRARVLYLSPTKALGHDQLRAAHALTAVIPRLHDVAPTAYDGDSPTEVRRFARERSRWLFSNPDMIHLSILRNHARWAVLLRGLRFVVVDECHYYRGVFGSNVAMVLRRLLRLCARYSSSPTVIFASATTDSPGATAAELIGLPVEEVSEDGSPQGARTVALWEPALRADLTGENGAPVRRSAGAEAARVMADLIAEGAQTLTFVRSRRAAELTALGAQARLDDVAPELSRTVASYRAGYLAEDRTALERALAEGRLRGLATTNALELGVDIAGLDAVVLAGFPGTVASFWQQAGRSGRRGQGALVVLIARDDPLDTYLVHNPAALLDKPVERVVIDPANPYILGPQLLCAATELPLDEAEVRTLGATEVADGLVDDGLLRRRAGKYFPVPGLEPHAAVDIRGSAGGQIVIVEADTGRLLGSAGAGQAPATVHPGAVYLHQGDSYVVDSLDTEEGIAFVHAEDPGYATFAREITDIAVTGAGERLAFGPVTLGLVPVRVTHQVVGFLRRRLSGEVIDFIELDMPEHTLATTAVMYTITEDALQRKGIEATQIPGALHAAEHAAIGLLPLVASCDRGDIGGLSTAVGPDPRGLPSVFVYDGYPGGAGFAERGFRRARTWLGATAAAIEACECPWGCPSCVQSPKCGNGNDPLDKAGAVLVLKLVLAELAQGPRENDPRG
>NZ_AP022590|5031869:5089629|5063998_5065072_+|WP_142275760.1|DBSCAN-SWA
MLAVLAESDMRAELDRVAAAAGVRVVHASDVAPVSRKSWAAAAAVVLDARAAARCGRWALPRRDHVTVLTVTEPETATWAAAVGVGAEHVLQLPGQEADLVGALAEAAESARDDGSRGHAVAVIGGCGGAGASLLAVALAQGATNALLVDLDPWGGGLDLLLGGESTPGLRWPDLALQGGRLNWSAVRDALPRHRGVSVLSGTRRGYELDAGPVHAVIDAGRRGAVTVVCDLPRRLTDATQAALSAADLVVVVSRCDVRACAATGALAPALASLNPNVGLVVRGPSPGGLRAAEIAEIAGLSLLATIKAQPQLAEQADRGGLRLGRRTALGVAARQVLAVLPPGAARRRAGQNGRAA
>NZ_AP022590|5031869:5089629|5065068_5066244_+|WP_083098956.1|DBSCAN-SWA
MSGSLIERVRERLAGEAGPPGAPLAASVVAAAIRAESGGMLGDTEVLANLRVLQTELTGAGILDPLLCADGTTDVLVTAPDAVWVDDGTGLRRTEVRFPDEASVRRLAQRLALAAGRRLDDAQPWVDGELTGIGPGGSAVRLHAVLPPVAAAGTCVSLRVLRPASQDLSALTAAGAIEPAAAALVTDIIGARLAFLVSGGTGAGKTTLLAAMLGAVSPAERIVCVEDAAELAPRHPHLVKLVARCANVEGVGEVPVRQLVRQALRMRPDRIVVGEVRGAEVVDLLAALNTGHDGGAGTVHANSPGEVPARLEALGALGGLDGAALHSQLAAAVQVLLHVERDRAGRRRLSEIAALQHDQGRVRAVTVWHADRGMTDAAPRLRNLLNSRMPA
>NZ_AP022590|5031869:5089629|5061436_5062195_+|WP_083098950.1|DBSCAN-SWA
MTADPLAPLMELPGVAEASDRARDALGRAHRHRANLRGWPVTAAEAALRAARASSVLDGGPVRLEDLADAGQISDPVFAGALRVAQALEGGEGPVVAIWRRAPLQALARLHVLAAAERVDDERLGRPRADAGVGPRLELLADLVNGRTRVPAPVLAAVAHGELLTLKPFGSSDGVVARAVSRLVTIASGLDPHGLGVPEVSWMRQPAAYRDAAQGFAEGTPEGVGAWLVLCCRAMKAGAQEAVSIADSMSNR
>NZ_AP022590|5031869:5089629|5042764_5043220_+|WP_083100113.1|DBSCAN-SWA
MSASARLGQLGLALPEVVAPLAAYVPAVRTGNLVYTAGQLPMEAGKLLATGKVGADVSPDQGKAMARTCALNALAAVNSLVGIDAVTRVVKVVGFVASAPGFNGQPGVINGASELFAEVFGEQGAHARSAVGVSELPLDAPVEVELIVEVG
>NZ_AP022590|5031869:5089629|5052885_5054835_-|WP_083098940.1|DBSCAN-SWA
MTATNTAGPSSYPPPAQFTEQANAGEEVYREAEQDRLAFWAKQANRLTWATPFTEVLDWSEAPFAKWFADGKLNVAYNCVDRHVEAGLGDRVAIHWEGEPVSDHRSLTYSDLQAEVCKAANALTDLGLVAGDRVAIYLPLIPEAVIAMLACARLGLMHSVVFAGFTAKALQARIADAQAKLLITSDGQFRRGKPAPLKDAADEAVNGDSPVEHVLVVRRTGIDVSWNDDRDLWWHDVVDAASPEHTPEPFAAEQPLFLLYTSGTTGKPKGIVHTSGGYLTHAAYTHYYVFDIKAESDVFWCTADIGWVTGHTYGVYGPLANGVTEVLYEGTPDSPSQHRHFEIIEKYGVTIYYTAPTLIRTFMKWGREIPDAHDLSSLRLLGSVGEPINPEAWRWYRKVIGADRLPIVDTWWQTETGATMISPLPGVAAAKPGSAMRPLPGISAKVVDDHGDQLPPGNDEGEHVAGYLVLDQPWPSMLRGIWGDPERFVETYWSRFAEHGWYFAGDSAYYDADGDIWVVGRIDDVMNVSGHRLSTAEVESALVGHVAVAEAAVVGATDETTGQAICAFVVLCADFHVHDGIVDELRVEVAREISPIARPREVHVVPELPKTRSGKIMRRLLRDIAENRELGDTSTLLDPGVFDAIKAAK
>NZ_AP022590|5031869:5089629|5045612_5046293_+|WP_083100119.1|DBSCAN-SWA
MNRALAQAFPDAHCELDFTTPLELTVATILSAQSTDKRVNLTTPALFKRYPSALDYAQANRDELENLIRPTGFFRNKASSLIGLGQALVERFDGEVPSTMAELVTLPGVGRKTANVILGNAFGIPGITVDTHFARLVHRWRWTADKDPVKIEHSVGELIERGEWTMLSHRVIFHGRRVCHARKPACGVCLIAKDCPSFGLGPTEAALAAPLVKGPETEHLLALAGL
>NZ_AP022590|5031869:5089629|5083339_5084608_-|WP_083098978.1|DBSCAN-SWA
MTEISASQGPVARGSMARVGTATAVTALCGYAVIYLAARDLAPSGFSVFGVFWGAFGLVTGAANGLLQETTREVRSTPYISDLAALPVPGEPRTHPMRVAMLVGVAAAVLIAGSSPLWSGRVFVEARLLSVVLLSVGLAGFCLHATLLGMLAGTNQWTRYGALMVTDAVIRVTVAAATVTLGWRLVGFLWATVAGAVAWLILLVASPATRATARLLTPGGTATFLRGAAHSITAAGASAILVMGFPVLLKLTSAELGAQGGVIILAVTLTRAPLLVPLTAMQGNLIAHFVDERSNRIRALLAPAGIVGAIGAVGVLAAGVIGPWLLRVAFGPQYHASSALLAWLTAAAVAIAMLTLTGAAAVAAALHRAYSLGWVSATVASGLLLLLPLSLQTRTVVGLLCGPVVGIGVHLLALSRATRSTG
>NZ_AP022590|5031869:5089629|5068515_5069553_-|WP_083099017.1|DBSCAN-SWA
MAHDWLLVETLGGDPTVVSQGRQLKNLVPITTFLRRSPYLAAVRTAIAESVQTGQALTSITPKRDRIIRTEPVVMSDGFIHGVHVWTGPADTDPPERPIPGPLKWDLTLGVATDTRESLINSGKNPEVEVTFGRAFAEDLPSRELNPNETKVLAMAVKAKPDQTLCSTWDLTDWRGESIRIGFVARTILEPGPDGREHLVARAINWQSELKGPEVSTDDLAQRILSGLAQAGVHRALIDLNTWTLLKWLDEPCTFYDWRTIEAGKPRVHPDDQDLMSTMTREFSGGATSRVLRLPGHDGDWVPVHVTVNRIELETDTYAGLVSLRLPTDEELATAGLSPPPDAAP
>NZ_AP022590|5031869:5089629|5084737_5085832_+|WP_083098980.1|DBSCAN-SWA
MSALRTFAISLVVTAAALALGYSYGGFKDLYLLVVLAALEVSLSFDNAIINAAVLKRMSRFWQRMFLTIGILVAVFGMRLLFPLLIVWATAGLDPVRAMELALHPPPHGALEFPDGSPSYEKLVIVAHPQIAAFGGIFLLMLFLDFVFYDRDIKWLKWIEIPFARIGRLGQVSLVVTGVVLVLVGTRLTHSADEAATVLTAGLLGLVTYLVVNGLSRAFRPSDTEADVESGAGAATGWAGLTLFLYLEVLDAAFSFDGVTGAFAITSDPIVIALGLGLVGSMFVRSITIYLVRQDALGRYVYLEHGAHWAIGALAVIMLFSIEPRFDVPEPVTASVGVVFIAAALGWSVLRNRRDARRGVTRPR
>NZ_AP022590|5031869:5089629|5067667_5067868_+|WP_083098961.1|DBSCAN-SWA
MINMFREFSARVALLAADESGMSTVEYAIGTIAAAAFGAVLYTVVTGDSIVSALTNIIGRALNTKV
>NZ_AP022590|5031869:5089629|5042589_5042751_+|WP_007772224.1|DBSCAN-SWA
MSQPTAWEYVTVPLLTHATKQILDQWGADGWELVSVLQGPTGEQHVAYLKRPK
>NZ_AP022590|5031869:5089629|5039863_5040214_+|WP_083100105.1|DBSCAN-SWA
MSPIRPAARRTNIAAAQGILRSVDAEERIAWVSRALCRTTDPDELFVRGAAQRKAAVICRHCPVMQECGADALDNKVEFGVWGGMTERQRRALLKQHPEVVSWADFFDKKRGRSVS
>NZ_AP022590|5031869:5089629|5088573_5089629_+|WP_083099022.1|protease|DBSCAN-SWA
MTSTPDLTLGTAVDWQFAATVGRRLARPGPPSSEYTQRQVIDELASASTKAEPLVRDVTGLVTDGAVPAARIVDRPDWIGAATESMRVMMNGAEKPRGFLTGRVTGAQTGAVLAYVSAAILGQYDPFATANGAKTGCLLLVYPNVIAVERQLRVEPSDFRLWVCLHEVTHRVQFTANPWLPGYMSQALGLLTRDTGEDMGQVIGRLAEYARNRGGPEPDANSSGILGLVRAVQSEPQRRALDQLLVLGTLLEGHADHVMDAVGPIAVPSVATIRRRFDERRHRKQPPVQRLLRALLGLDAKLSQYTRGKAFVDHVVGQVGMARFNAIWTGPETLPLPSEIEEPQRWIDRVL
>NZ_AP022590|5031869:5089629|5072630_5073230_+|WP_083098965.1|DBSCAN-SWA
MSQLSFFTAESVPPAATDLSGVLAASGQIVTVGATGESRVAGARLSVVVDHAWRASALAEMIREAGLVAEISRTDEDTPLVRTAVDPSLSTLATEWTRGAVKTVPPRWLPGPRELRAWTLAAGNPEGEHYLLALDPHAPDTHSPLASALMRVGIAPTLIGTRGGRPALRITGRRRLSRLVENVGEPPDGAEALSRWPRV
>NZ_AP022590|5031869:5089629|5040345_5041503_-|WP_083100109.1|DBSCAN-SWA
MSTTPTPLDMAAILADTTNRVVVCCGAGGVGKTTTAAAIALRAAEYGRNVCVLTIDPAKRLAQALGVSDLGNTPQRVPLAAEVPGELHAMMLDMRRTFDEMVVQYSGPGRAQAILDNQFYQTVASSLAGTQEYMAMEKLGQLLAEDRWDLVVVDTPPSRNALDFLDAPKRLGSFMDSRLWRLLLAPGRGIGRLVTGAMGLAMKAMSTILGSQMLGDAAAFVQSLDATFGGFREKADRTYALLKRRGTQFVVVSAAEPDALREAAFFVDRLSQEGMPLAGLVLNRTHPPLCSLPAERAIDGSEMLDHDADSEAASLASAVLKIHADRAQTAKREIRLLSRFTGAHPHVPVIGVPSLPFDVSDLEALRALADQITSVGDEAGRATAR
>NZ_AP022590|5031869:5089629|5044263_5044938_-|WP_036465140.1|DBSCAN-SWA
MDEILARAGIFQGVEPGAVTALTKQLQPVDFPRGHTVFAEGEPGDRLYIIVSGKVKIGRRSPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRAWIADRPEIAEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGAMRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR
>NZ_AP022590|5031869:5089629|5054950_5055490_+|WP_083098941.1|DBSCAN-SWA
MPGHGRGLRRLIPSFAAAATIYAAATALGWPVSAVPIEGDQATPCRSEQVAVNVSPAQGAVGHRGLALMFSLAGGADPCTLTGYAGVDSGAGGPLIHALPTLRGYMGGLPDGVDVPPAVLLSISTQGQAIVEGMAVDADGAPCPTYTELSVNPPDTEIVLTVAATIDACALQVHPITAV
>NZ_AP022590|5031869:5089629|5087191_5088577_+|WP_142275761.1|DBSCAN-SWA
MAGTRWQKSTPVFIGLGVLAFVAAVVVAATFFTTSGHGANSAHAPIPPPHAPTVKPGMVPVSDTAELPSGPGVGAMLAAVAGDPNLGRLGGRVTDAITGKELWQVADDMPLVPASTNKVLTAAAALLTLDRQARISTRVVAGSQNAQGPVVLVGAGDPALSAAPPGVDTWYRGSARISDLVEQIRRSGVTPTGVQVDTSAFSGPTIAQGWDLADIDNGDIAPIESVMIDAGRIQPSTVNSRRSHTPALDAGRELAKALGLDPNAVTIANAPSGARQLAVVQSAPLVQRLSEMMDHSDNVLAESIAREVAAAINRPRSFAGAADAVSNRLTTAHVDTAGVALLDSSGLSVDDRLTAKTLDGVLQAAAGPDQPSLRALLDLLPIAAGSGTLADRFTDASTAQGPAGWLRAKTGSLTGINALAGVLTDRSGRVLTFAFLSNNAGPNGRNVMDALATRLWSCGCS
>NZ_AP022590|5031869:5089629|5036067_5037027_-|WP_083100101.1|DBSCAN-SWA
MADVLPVLIRAGAAALGTSVAGLGYAAVIERNAFVLREITMPVLTPGSTPLRVLHISDLHMTPGQRRKQAWLRELAGWEPDLVVNTGDNLAHPKAVPSVIQALGDLLSRPGVFVFGSNDYFAPRLKNPLNYVTNPSHRVRGEPLPWQDLRAAFTERGWLDLTHTRREFEVAGLHVAAAGVDDPHIDRDRYETIAGPASPAANLRLGLTHSPEPRVLDRFAADGYQLVMAGHTHGGQVCLPFYGALVTNCGLDRSRAKGPSRWGAHMRLHVSAGMGTSPFAPVRFCCRPEATLLTLIATPMGDRDAASDLSRSQPTASVR
>NZ_AP022590|5031869:5089629|5033210_5034504_+|WP_163650845.1|transposase|DBSCAN-SWA
MPSKYDPQTRAKAVRLVLEHRADYPSEWAAITAVSKRLGMTAETLRSWIRQQQVDDGDRDGVSSAAAAEIRALKRRNAELEQTIEILKAATFFLRAGERPAQPPLTSSVCEFIAKHRHRFGVAPICRVLTEHGVPIAPRTFYAWVKRAPSKRALWDATISEVLAGYYEPDEHGRRKPESLYGSVKMWAHLQRKGIPVAKSTVERLMRRNGWQGVRRQKAVRTTIADPAAVRPPDLVDRQFGVGAPNQLLVADFTYVKLVTGVFVYVAFVIDAYAGAIVGWEACASKQTQFVESAIRQAVALRSRQGHPIEDAIHHSDAGSQYTSVRFGETLALSGIRPSVGSVGDAYDNALAETTIGLYKTECIRPDSPFRRGPLTTVGDVEYITADYVAWYNQQRLMHRLGRVPPAEAEAQYYSQHVTDQPAGSQNPEGA
>NZ_AP022590|5031869:5089629|5055496_5056303_-|WP_083098943.1|DBSCAN-SWA
MTVAYLASHESGVRAGYLMFWLGVPAIGLVCLVIGLVERSRSRRRAPGYPPQYPPGFPVHPGYPYPPPPGYAAAPYPGYAPGHPPRPRAPKSATALITMGAVLLTLGGLGILGNAARVLAGLGASAIGDTSLRVGDCISESDYKAQHFNSSSSGGCTDPAATYELASRSGAGDTCPDGKREHSVYDRFTNDSTILCFAVNLKEGQCYQMISDGDAMTLRLGDCDKPGRAQVKVSQRIDGSSDKSQCPSDSRGIAYPIPARVYCLVRAD
>NZ_AP022590|5031869:5089629|5072259_5072463_+|WP_007772268.1|DBSCAN-SWA
MPQGTVKWFNAEKGFGFIAPEDGSADVFVHYTEIQGSGFRTLEENQKVEFEIGHSPKGPQATGVRSL
>NZ_AP022590|5031869:5089629|5082602_5083304_-|WP_083098976.1|DBSCAN-SWA
MGTETHYSVVWVVIPAFNEAAVIGEVVADVRSVFDHVVCVDDGSADDTGEIARRAGAHLVRHPINLGQGAAIQTGVEYARKQPGAEVFATFDADGQHRVKDLVTMVDRLRAGDVDVVIGTRFGAQHGARPPFVKRIVLQTAARLSRRGRRLGLTDTNNGLRVFNKKVADGLDITMSGMSHANEFIMLIDENHWRVAEEPIEVLYTAYSRSKGQPLLNGVNIIFDGFLRGRIPR
>NZ_AP022590|5031869:5089629|5067915_5068185_+|WP_083098963.1|DBSCAN-SWA
MVLVLCLAGITAISMQVRCVDAAREAARLAARGDERSAVSAARRLAPARARVDLRRDGDFLVATVVAHSKLLPTIDIAAKAVSAAEPSR
>NZ_AP022590|5031869:5089629|5041499_5042519_-|WP_083100111.1|DBSCAN-SWA
MATTSSGGAAVGWPARLTKARLHIVTGKGGTGKSTIAAALALTLAAGGRKVLLVEVEGRQGIAQLFDVPPLPYQEVKIATAERGGQVNALAIDIEAAFLEYLDMFYNLGIAGRAMRRIGAIEFATTIAPGLRDVLLTGKIKETVIRVDKNRLPVYDAIVVDAPPTGRIARFLDVTKAVSDLAKGGPVHSQADGVVKLLHSEQTAIHLVTLLEALPVQETLEAIEELAEMQLPIGSVIVNRNIPSYLQPADLAKAAEGDVDADSVRAGLEKSGITLNDKDFAGLLTETIEHATVVATRADIAQQLDALKVSRLELPAISDGVDLGSLYELSESLAQQGVR
>NZ_AP022590|5031869:5089629|5037082_5039512_-|WP_083100103.1|DBSCAN-SWA
MSDRPPAALTILKLAGLCLLASVVATALLFPFAGGIGLVSNRASEVVTNGSAQLLEGEVPAVSTMVDAKGNTIAWLYSQRRFEVPSDKIANTMKLAIVSIEDKRFAEHNGVDWKGTLTGLAGYARGDVDTRGGSTIEQQYIKNYQLLVTAKTDAEKRAAVETTPARKLREIRMALTLDKTFTKPEILTRYLNLVSFGNGSFGVQDAAQTYFGINASDLNWQQAALLAGMVQSTSALNPYINPDGALARRNLVLDTMIENIPQEADALRAAKATPLGILPQPNELPRGCIAAGDRAFFCDYVQEYLSRAGISKEQVARGGYLIKTTLDPDVQIPVKTAIDKFASPTLPGISSVMSVIQPGKTSHKVMAMASNRTYGLDVDAGQTMRPQPFSLVGDGAGSVFKIFTTAAALDMGMGTNAILEVPGRFQAKGMGSGGAKGCPKDNWCVVNAGNYRGSMNVTDALATSPNTAFAKLIQQVGVTRTVDMAIKLGLRSYADPGTARDYNPDSNESLADFVKRQNIGSFTLGPIEVNALELSNVAATLASGGTWCPPNPIDKLVDRKGNEVAVTTETCDQVVPDGLANTLANAMSKDALGGGTAAGSASAAGWDLPVSGKTGTTEAHRSSGFVGFTNHYAAANYIYDDSPNPTDLCSSPLRHCGEGDLYGGNEPARTWFTAMKPIATNFGPVQLPPTDPRYVDGAPGSRVPSVAGLDIDAARQRIKEAGFQVADQNSFVNSSAKQGEVVGTTPSGATIPGSIITIQVSNGIPPAPPPPPEGAPPPVGSQVVEIPGLPPITIPLLAPPPPAPGQPPP
>NZ_AP022590|5031869:5089629|5068201_5068519_+|WP_083099015.1|DBSCAN-SWA
MVAAWMVVVLLTATGAGAYLGSAVVARHRAQAVADLAALAAAARLSSGGAAACAVAAGVARRMRVDDIRCVVDGLDVVITARVAVAFGGAARAAARAGPATGASD
>NZ_AP022590|5031869:5089629|5067055_5067649_+|WP_083099013.1|DBSCAN-SWA
MQSAAALLAVALWIGPGPALVRSRAGMPARGGRLRRRAAPARGLDPLAVASCLDVLAVCLEAGMAVSAAAAAAAPSAPPNLARVLRRAADLLALGADPAVAWSIPSGPQNPADPQIDALLRLARRSASSGAALAGGVADLAEESRQDTAHAATAAAERAGVLIAGPLGLCFLPAFVCLGIVPVVAGLAGDVLQSGLL
>NZ_AP022590|5031869:5089629|5059797_5061432_+|WP_083099011.1|DBSCAN-SWA
MSGTVSPLLSVEGLEVGFGDHAAVRGLDLSVLPGQTVAVVGESGSGKSTTAAAILGLLPPGGRITAGRIMFDGVDISAADRRALRSIRGREIGYIPQDPMTNLNPVWKVGFQIREALRANTTDRGTRQRAVELLAAAGMPDPARQAGRYPHQLSGGMCQRALIAIGLAGRPRLLIADEPTSALDVTVQRQVLDHLQRLTAELGTALLLITHDLALAAERAESVVVVHRGVVVESGAARSILCSPQHEYTRRLVAAAPALTIRGPARPRATAETEHPEGILVAAALTKVYREAHGAPWRRTEFRAVDAVSFRLRRASTLAIVGESGSGKSTVARMVLGLLPPTSGTVEFDGVRIDGAMPRDKQLAFRRRVQPVFQNPYSSLDPMYSVFRAIEEPLRIHRVGDRGQRAQAVHDLIEQVALPSSVLDRLPRELSGGQRQRVAIARALALRPEVLVCDEAVSALDVLVQAQILDLLAELQAELGLAYLFISHDLAVIRQIADDVLVMRAGRVVEHGPTGQLFSDPGHEYTRQLLDAIPHPLESGGDRL
>NZ_AP022590|5031869:5089629|5086579_5087068_-|WP_083098983.1|DBSCAN-SWA
MEFDVTIEIQKGQRNKYEVDHETGRLRLDRYLYTAMAYPTDYGFIEDTLGEDGDPLDAMVLLPQSVFPGVIVEARPVGMFRMTDEKGGDDKVLCVPAGDHRWDHVQDIGDVPEFELDVIKHFFVHYKDLEPGKFVKAADWVGRDEAEAEIQRSIERFKAQGH
>NZ_AP022590|5031869:5089629|5058018_5058945_+|WP_083098946.1|DBSCAN-SWA
MGWYIARRIAVMVPVFLGATLLIYGMVFLLPGDPLAAIAGDRPLTPAVAAALRARYHLDDPFIVQYLRYLGGVVRGDLGRAYSGLPVSAVLAHAFPVTIRLALIALVVEAVLGIGFGVMSGLRQGGLFDATVLITGLIIIATPIFVLGFLAQFLFGVKLGIAPVTVGERATFARLLLPGIVLGSVSFAYIVRLTRSAVAANAHADYVRTATAKGLARPRVVTVHILRNSLIPVVTFLGADLGALMGGAIVTEGIFNIHGVGGVLYQAVTRQEAPTVVSVVTVLVLIYLVTNLMVDLLYAALDPRIRYA
>NZ_AP022590|5031869:5089629|5062657_5063515_-|WP_083098952.1|DBSCAN-SWA
MTVFDPTAEQSAPEQSAATTSPHARTAAFFDLDKTIIAKSSTLAFSKPFFNQGLLNRRAVLKSSYAQFIYLLSGADHDQMDRMRAHMANMCTGWDVEQVKSIVNETLHDIVTPLVFAEAADLIAAHKLCGRDVVVVSASGEEIVAPIARALGATHAMATRMVVEDGRYTGEIAFYCYGEGKVQAIRELAAREGYPLEHCYAYSDSITDLPMLESVGHPSVVNPDRGLRREALERGWPVMSFSRPVSLRDRIPAPSGAAIATTAAVSISALAAGAVTYSLIRRYAF
>NZ_AP022590|5031869:5089629|5043225_5044026_+|WP_083100115.1|DBSCAN-SWA
MTQAAEPLTHPAYAKLRAVTETASVLLADNPGLLTLEGTNTWVLRGPRSDELVIVDPGPDDDEHIARIAALGRIALVLISHRHSDHTDGIDKLVELTGATVRSAGSGFLRGLGGELTDGEVIHAAGLEIKVMATPGHTADSLSFLLDDAVLTADTVLGRGTAVLDKEDGSLTDYLESLRRLRGLGRRTVLPGHGPDLPDLESVAQGYLAHRRERLGQVRSALRELGEDAGARRIVEHVYVDVDEKLWDAAEWSVQVQLNHLRSSPA
>NZ_AP022590|5031869:5089629|5079461_5081279_-|WP_142275757.1|DBSCAN-SWA
MNPAAPVTSARTGPPYIAVAAAALIAVQLAVRGVLAFGGYFYWDDLILIGKAGTHNLLAPSYLFDDHDGHVMPGAFLVAGTIIRLAPLDWTWPAVSLLVLQLLASLALLRALYVILGWRPVLLIPFTFALFTPLGVPGFAWWAAALNSLPMLAALAWVCADAILLVRTGKRRYAVTGVLVYFGGLLFFEKAAVIPFVAFAVAALLSHVTGDRSLGSSLATVWRAGLRLWIGALALTAAWIALYLAVVNQQRWSSDLAMTCRLLVRSITHGIVPGLAGGPWHWDRWAPASPWATPPPAVMALGWLVLVGILAVSLVRKERIGPVWLVTVGYAVACQVPIYLMRSSNQTALELAQTLRYLPDLVVVLALLAAVALSAPNRRAGPQWLDASPKRTAVTAGVAVLFAASSLYSTATFLTSWRDNPAQPYLQNARAALAEAHTASDAPLLDQEVDPFVLQRVAAPENLASHLFALLRDRPEFAPATTQLRMFDNSGRLVKARVTWVRTIAPGPIPRCGYFAQPDNPARLVLDGPLLPADWTVELNYLANSDGSMTLSMTQGPEVKVPVHPGLNRVYARLPGAGDAITVRANTTALALCLASGPVGFVASA

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_142275582.1|5031869_5033131_-|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	7.4e-83	60.1
WP_163650845.1|5033210_5034504_+|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	1.7e-58	54.8
WP_142275812.1|5034955_5036005_-	pyridoxal-phosphate dependent enzyme	NA	NA	NA	NA
WP_083100101.1|5036067_5037027_-	metallophosphoesterase	NA	NA	NA	NA
WP_083100103.1|5037082_5039512_-	transglycosylase/D,D-transpeptidase PonA2	NA	NA	NA	NA
WP_083100105.1|5039863_5040214_+	WhiB family transcriptional regulator	A0A159B6S6	Tsukamurella_phage	2.3e-10	50.0
WP_083100109.1|5040345_5041503_-	ArsA family ATPase	NA	NA	NA	NA
WP_083100111.1|5041499_5042519_-	ArsA family ATPase	NA	NA	NA	NA
WP_007772224.1|5042589_5042751_+	DUF4177 domain-containing protein	NA	NA	NA	NA
WP_083100113.1|5042764_5043220_+	RidA family protein	M1I5B0	Acanthocystis_turfacea_Chlorella_virus	2.1e-19	38.1
WP_083100115.1|5043225_5044026_+	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_036465140.1|5044263_5044938_-	cAMP-activated global transcriptional regulator CRP	NA	NA	NA	NA
WP_083100117.1|5045043_5045424_-	hypothetical protein	NA	NA	NA	NA
WP_083100119.1|5045612_5046293_+	endonuclease III	NA	NA	NA	NA
WP_083100121.1|5046326_5046983_+	TlpA family protein disulfide reductase	NA	NA	NA	NA
WP_083100123.1|5047012_5047825_+	CoA pyrophosphatase	NA	NA	NA	NA
WP_163650845.1|5048821_5050115_+|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	1.7e-58	54.8
WP_083098931.1|5050399_5051359_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_083098936.1|5051359_5051902_-|holin	phage holin family protein	NA	NA	NA	NA
WP_142275755.1|5052177_5052876_+|protease	serine protease	NA	NA	NA	NA
WP_083098940.1|5052885_5054835_-	acetate--CoA ligase	A0A2H4PQU7	Staphylococcus_phage	1.6e-89	39.8
WP_083098941.1|5054950_5055490_+	DUF4232 domain-containing protein	NA	NA	NA	NA
WP_083098943.1|5055496_5056303_-	hypothetical protein	NA	NA	NA	NA
WP_083098944.1|5056377_5058015_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_083098946.1|5058018_5058945_+	ABC transporter permease	NA	NA	NA	NA
WP_083098948.1|5058937_5059801_+	ABC transporter permease	NA	NA	NA	NA
WP_083099011.1|5059797_5061432_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	5.0e-15	32.6
WP_083098950.1|5061436_5062195_+	oxidoreductase	NA	NA	NA	NA
WP_083098952.1|5062657_5063515_-	HAD-IB family hydrolase	NA	NA	NA	NA
WP_142275760.1|5063998_5065072_+	helicase	NA	NA	NA	NA
WP_083098956.1|5065068_5066244_+	TadA family conjugal transfer-associated ATPase	NA	NA	NA	NA
WP_083098958.1|5066240_5067041_+	type II secretion system F family protein	NA	NA	NA	NA
WP_083099013.1|5067055_5067649_+	type II secretion system F family protein	NA	NA	NA	NA
WP_083098961.1|5067667_5067868_+	DUF4244 domain-containing protein	NA	NA	NA	NA
WP_083098963.1|5067915_5068185_+	pilus biosynthesis protein TadE	NA	NA	NA	NA
WP_083099015.1|5068201_5068519_+	helicase	NA	NA	NA	NA
WP_083099017.1|5068515_5069553_-	DUF5593 domain-containg protein	NA	NA	NA	NA
WP_083099018.1|5069624_5071964_-	DEAD/DEAH box helicase	A0A1B1IUF6	uncultured_Mediterranean_phage	2.1e-06	28.5
WP_007772268.1|5072259_5072463_+	cold shock protein CspA	A0A1X9IGI9	Lactococcus_phage	8.9e-15	57.8
WP_083098965.1|5072630_5073230_+	hypothetical protein	NA	NA	NA	NA
WP_083098967.1|5073444_5076270_+	type I DNA topoisomerase	J3E777	Acanthamoeba_polyphaga_lentillevirus	5.8e-96	33.6
WP_142275756.1|5076276_5077905_-	HAMP domain-containing protein	A0A1B1IWY2	uncultured_Mediterranean_phage	2.2e-18	32.8
WP_083098971.1|5078059_5079268_+	DNA polymerase III subunit delta'	NA	NA	NA	NA
WP_142275757.1|5079461_5081279_-	hypothetical protein	NA	NA	NA	NA
WP_142275758.1|5081244_5082189_+	GDP-mannose 4,6-dehydratase	E3T4Y8	Cafeteria_roenbergensis_virus	1.4e-30	30.8
WP_083098974.1|5082220_5082589_-	DUF2304 domain-containing protein	NA	NA	NA	NA
WP_083098976.1|5082602_5083304_-	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_083098978.1|5083339_5084608_-	hypothetical protein	NA	NA	NA	NA
WP_083098980.1|5084737_5085832_+	DUF475 domain-containing protein	A0A172Q0Y5	Acinetobacter_phage	6.7e-56	39.2
WP_083098981.1|5085828_5086521_-	hypothetical protein	NA	NA	NA	NA
WP_083098983.1|5086579_5087068_-	inorganic diphosphatase	A0A2H4J8U1	uncultured_Caudovirales_phage	6.6e-32	47.2
WP_142275761.1|5087191_5088577_+	D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase	NA	NA	NA	NA
WP_083099022.1|5088573_5089629_+|protease	zinc-dependent metalloprotease	NA	NA	NA	NA