CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NZ_AP022623	Mycobacteroides abscessus strain JCM 30620 plasmid pJCM30620_2	0 crisprs	NA	0	0
NZ_AP022622	Mycobacteroides abscessus strain JCM 30620 plasmid pJCM30620_1	0 crisprs	c2c9_V-U4	0	1
NZ_AP022621	Mycobacteroides abscessus strain JCM 30620	2 crisprs	csa3,WYL,cas3,cas4,DEDDh,DinG	1	8

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

92969 : 101650

Mycobacterium_phage(88.89%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016341451.1\|92969_93614_-	hypothetical protein	V5UQP3	Mycobacterium_phage	4.6e-49	49.1
WP_157929382.1\|93610_93784_-	hypothetical protein	NA	NA	NA	NA
WP_041928326.1\|93780_94407_-	hypothetical protein	NA	NA	NA	NA
WP_016341450.1\|94403_94652_-	glutaredoxin-like protein NrdH	V5UN81	Mycobacterium_phage	8.3e-23	64.6
WP_041928323.1\|95130_95433_-	hypothetical protein	V5UPD3	Mycobacterium_phage	4.5e-31	63.0
WP_041928321.1\|95465_96080_-	hypothetical protein	V5UP21	Mycobacterium_phage	3.6e-75	70.8
WP_016341448.1\|96121_96463_-	hypothetical protein	NA	NA	NA	NA
WP_041928319.1\|96588_96867_-	hypothetical protein	A0A0A7HAI7	Mycobacterium_phage	3.0e-21	68.8
WP_041928317.1\|96863_97370_-	hypothetical protein	NA	NA	NA	NA
WP_041928315.1\|97366_97816_-	hypothetical protein	NA	NA	NA	NA
WP_016341446.1\|97891_98932_-	DUF945 domain-containing protein	Q1A023	Mycobacterium_phage	9.1e-71	44.2
WP_163926301.1\|99397_100441_-	hypothetical protein	V5UQR1	Mycobacterium_phage	9.2e-55	44.2
WP_163926303.1\|100383_101139_-	ParB N-terminal domain-containing protein	V5UQR1	Mycobacterium_phage	9.0e-52	54.0
WP_016341444.1\|101254_101650_-	single-stranded DNA-binding protein	A0A0U4IHP1	Arthrobacter_phage	2.3e-19	50.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_AP022621

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CRISPR-Cas detection and classification

Crispr_ID: NZ_AP022621_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022621_1

2336652-2336739

Orphan

Consensus_repeat	Method
CCAGCCACCGCACACGCCGTTGTAGCAGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022621_1

>merge|NZ_AP022621|1|2336652-2336739|CRISPRCasFinder
CCAGCCACCGCACACGCCGTTGTAGCAGCCGTGGCCCCAACCACCCTGGCCGGGGTTCCAGCCACCGCACACGCCGTTGTAGCAGCCG

>NZ_AP022621|1|1|2336652-2336739|CRISPRCasFinder
CCAGCCACCGCACACGCCGTTGTAGCAGCCG	TGGCCCCAACCACCCTGGCCGGGGTT
CCAGCCACCGCACACGCCGTTGTAGCAGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022621.1\|WP_016341946.1\|2342315_2342993_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_AP022621.1\|WP_016341950.1\|2331164_2332685_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143434
NZ_AP022621.1\|WP_005065999.1\|2337023_2337467_-\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|378454
NZ_AP022621.1\|WP_005063549.1\|2335039_2335603_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380066
NZ_AP022621.1\|WP_016341947.1\|2338932_2339766_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|225852
NZ_AP022621.1\|WP_005063548.1\|2333076_2335089_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340868
NZ_AP022621.1\|WP_005063544.1\|2328865_2330656_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223021
NZ_AP022621.1\|WP_005063562.1\|2344092_2344824_-\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|236115
NZ_AP022621.1\|WP_005063541.1\|2327221_2328004_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319911
NZ_AP022621.1\|WP_005063556.1\|2338662_2338878_-\|antitoxin	unknown	unknown	gnl\|CDD\|379416
NZ_AP022621.1\|WP_005063561.1\|2342989_2344096_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293841
NZ_AP022621.1\|WP_005063540.1\|2325989_2327195_+\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|179663
NZ_AP022621.1\|WP_005116170.1\|2344839_2345937_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224983
NZ_AP022621.1\|WP_016341948.1\|2335694_2336615_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274648
NZ_AP022621.1\|WP_005102410.1\|2337503_2338640_-\|lipase	unknown	unknown	gnl\|CDD\|367570
NZ_AP022621.1\|WP_005066010.1\|2328129_2328876_+\|peroxide-stress-protein-YaaA	unknown	unknown	gnl\|CDD\|234999
NZ_AP022621.1\|WP_005063545.1\|2330749_2331184_-\|DUF779-domain-containing-protein	unknown	unknown	gnl\|CDD\|377532
NZ_AP022621.1\|WP_005063558.1\|2339795_2342198_-\|cation-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319795
NZ_AP022621.1\|WP_005066003.1\|2332760_2332916_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239527
NZ_AP022621.1\|WP_005063565.1\|2345916_2346498_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP022621.1\|WP_016341946.1\|2342315_2342993_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	8.95291e-22
NZ_AP022621.1\|WP_016341950.1\|2331164_2332685_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143434	cd07116, ALDH_ACDHII-AcoD, Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like. Included in this CD is the NAD+-dependent, acetaldehyde dehydrogenase II (AcDHII, AcoD, EC=1.2.1.3) from Ralstonia (Alcaligenes) eutrophus H16 involved in the catabolism of acetoin and ethanol, and similar proteins, such as, the dimeric dihydrolipoamide dehydrogenase of the acetoin dehydrogenase enzyme system of Klebsiella pneumonia. Also included are sequences similar to the NAD+-dependent chloroacetaldehyde dehydrogenases (AldA and AldB) of Xanthobacter autotrophicus GJ10 which are involved in the degradation of 1,2-dichloroethane. These proteins apparently require RpoN factors for expression.	0
NZ_AP022621.1\|WP_005065999.1\|2337023_2337467_-\|SRPBCC-family-protein	gnl\|CDD\|378454	pfam10604, Polyketide_cyc2, Polyketide cyclase / dehydrase and lipid transport. This family contains polyketide cylcases/dehydrases which are enzymes involved in polyketide synthesis. It also includes other proteins of the START superfamily.	6.54669e-14
NZ_AP022621.1\|WP_005063549.1\|2335039_2335603_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|380066	pfam17940, TetR_C_31, Tetracyclin repressor-like, C-terminal domain. This is the C-terminal domain found in putative transcriptional regulator, TetR family proteins.	6.62571e-07
NZ_AP022621.1\|WP_016341947.1\|2338932_2339766_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|225852	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism].	1.7515e-47
NZ_AP022621.1\|WP_005063548.1\|2333076_2335089_+\|MFS-transporter	gnl\|CDD\|340868	cd06179, MFS_TRI12_like, Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters. This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.84197e-66
NZ_AP022621.1\|WP_005063544.1\|2328865_2330656_-\|hypothetical-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	0.000103621
NZ_AP022621.1\|WP_005063562.1\|2344092_2344824_-\|enoyl-CoA-hydratase	gnl\|CDD\|236115	PRK07854, PRK07854, enoyl-CoA hydratase; Provisional.	5.5316e-136
NZ_AP022621.1\|WP_005063541.1\|2327221_2328004_-\|VOC-family-protein	gnl\|CDD\|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	1.84839e-40
NZ_AP022621.1\|WP_005063556.1\|2338662_2338878_-\|antitoxin	gnl\|CDD\|379416	pfam14013, MT0933_antitox, MT0933-like antitoxin protein. This family of proteins contains the MT0933 protein, which has been identified as an antitoxin to /protein MT0934. This family of proteins is found in bacteria. Proteins in this family are typically between 61 and 90 amino acids in length.	4.21227e-08
NZ_AP022621.1\|WP_005063561.1\|2342989_2344096_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293841	cd16283, RomA-like_MBL-fold, Enterobacter cloacae RomA and related proteins; MBL-fold metallo hydrolase domain. Derepression of the romA-ramA locus results in a multidrug-resistance phenotype. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	6.49522e-68
NZ_AP022621.1\|WP_005063540.1\|2325989_2327195_+\|DNA-polymerase-IV	gnl\|CDD\|179663	PRK03858, PRK03858, DNA polymerase IV; Validated.	0
NZ_AP022621.1\|WP_005116170.1\|2344839_2345937_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224983	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism].	2.16826e-35
NZ_AP022621.1\|WP_016341948.1\|2335694_2336615_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274648	TIGR03560, F420_Rv1855c, probable F420-dependent oxidoreductase, Rv1855c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes one such subfamily, exemplified by Rv1855c from Mycobacterium tuberculosis. [Unknown function, Enzymes of unknown specificity].	3.16234e-71
NZ_AP022621.1\|WP_005102410.1\|2337503_2338640_-\|lipase	gnl\|CDD\|367570	pfam03583, LIP, Secretory lipase. These lipases are expressed and secreted during the infection cycle of these pathogens. In particular, C. albicans has a large number of different lipases, possibly reflecting broad lipolytic activity, which may contribute to the persistence and virulence of C. albicans in human tissue.	5.45097e-17
NZ_AP022621.1\|WP_005066010.1\|2328129_2328876_+\|peroxide-stress-protein-YaaA	gnl\|CDD\|234999	PRK02101, PRK02101, peroxide stress protein YaaA.	1.51257e-69
NZ_AP022621.1\|WP_005063545.1\|2330749_2331184_-\|DUF779-domain-containing-protein	gnl\|CDD\|377532	pfam05610, DUF779, Protein of unknown function (DUF779). This family consists of several bacterial proteins of unknown function.	2.62965e-69
NZ_AP022621.1\|WP_005063558.1\|2339795_2342198_-\|cation-translocating-P-type-ATPase	gnl\|CDD\|319795	cd02609, P-type_ATPase, uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7. This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.	0
NZ_AP022621.1\|WP_005066003.1\|2332760_2332916_-\|hypothetical-protein	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	1.90021e-05

>NZ_AP022621.1|WP_016341948.1|2335694_2336615_+|LLM-class-flavin-dependent-oxidoreductase
MRFSIWGQTNQSWADLLDIAQYADDGTWRAFYAADHFMSHADTAEERTDFHEATALFAALAAATSRIRLAPLVLSMTFRHPAVLANWAATVDHVSQGRFTLGLGAGWQENEHQRYGLELGKPGARVDRFSEGLQVITGLLNEPATTVDGQYYRLAEGICEPKPLQRPLPILIGATQPRMLALTARYAHEWNQWSSPGTFREVSGRLDAAAEKIGRDPATIWRSTQARVIVTDGPQSEARAAETAAASPIPVLYGTAERIAEQMAPWAQEGVDEVILPDHLLGSGSARRDAYDALAQALRPLSNEKG
>NZ_AP022621.1|WP_005063549.1|2335039_2335603_-|TetR-family-transcriptional-regulator
MIAAAIEVAGTMGIGGLTYRSVDAAANVPSGTTSNHFRTRDALLLGAILEIEKLRRAFWRALVTEINPTTVSDLVGIGTAYANGAVGAMSTRVRAYMALLMEGWSHPELREPLQRGRDAQIPRTLHLMCKVDPKTPQLHAEIFQDYLTGIIYQQLANPVADFNPRPGIEALLTALVTPPQTPRAAQR
>NZ_AP022621.1|WP_005063548.1|2333076_2335089_+|MFS-transporter
MISVQRRNLIFVAVLLGMLLAALDGTIVATALPTVVADLGDAGHQSWVVTSYLLASTVATAVMGKFGDLFGRRTVFITCIVIFAGGSLLCGMAGSMAMLVGARAIQGLGSGGLMVTATALIGEIIPMRERGRYQGILGAVFGVTTVIGPLLGGLFTDHLGWRWAFYINLPISVVVIMVAAGAIPALAKATHPVIDYWGIVLIGLGASALTLATSWGGTTYPWSSPVIIGLFASSIAAIGTFVWVESRVPEPILPPRLFRDPVFTICCVLSFVVGFAMLGVMTYLPTFMQFVNGVSATVSGLRTLPMVAGMLITSTGTGTLVGRTGRYKRYPVAGTAIMAIALVLLSRMDDSTPFVLQSLYLFILGVGIGASMQVLTLIVQNTARFDDLGVATSGVTFFRTIGSSFGAAIFGSLFSNFLTRELSSVNTPPQATQSPQALHALPHDAAVPVIHAYADSLDLVFLCAAPVAAVGFVLALFLKEVPLRGADTSLAVDMGEGFGMPNSVSPDKLLEIAIGNAMRGFPHVGLRKLREHAGVSMPIAPLWALVQANRFLRATGSAEVSRIAQWYRIPPEIVDPAFNELVANGYALRTNDHIWLTDSGREEVDKISEAINQYLIERLSRTPDFEDRADREQIQAALERISRRIVTDTDWRENPIAALPAASGAASPAR
>NZ_AP022621.1|WP_005066003.1|2332760_2332916_-|hypothetical-protein
MCGYGCLASLPEGASGCTTVELKTNFLGAAREGKLTAAVFRCTQLVLWPRG
>NZ_AP022621.1|WP_016341950.1|2331164_2332685_-|aldehyde-dehydrogenase-family-protein
MAKYAAPGTEGSAVTFAPRYENFIGGEWVAPADGQYFENASPIDGKVFTQVARGTAPDIEKALDAAHAAAEGWGNTSAAERSNALLRIADRMEQHIERLAVAETWDNGKPIRESLNADIPLAIDHFRYFAGVLRAQEGSISEIDHDTVAYHFHEPLGVVGQIIPWNFPLLLAVWKLAPALAAGNCVVLKPAEQTPASILVLMELIADLLPSGTVNVVNGFGVEAGKPLASSPRIAKIAFTGETTTGRLIMQYATENIIPVTLELGGKSPNIFMPDVMAADDAFLDKALEGFTMFALNQGEVCTCPSRALVHASIYDEFIARAITRVEAIVGGDPLDEDTMIGAQASNDQYEKILSYIDIGRQEGAQVLTGGDARKVAEYPDGAYIQPTVFAGTNNMRIFQEEIFGPVLSVAKFDSLDEALKIANDTLYGLGAGVWSRDMTNAYRLGRGIKAGRVWTNCYHQYPAHAAFGGYKKSGIGRENHKMMLDHYQQTKNILVSYSPDAAGFF
>NZ_AP022621.1|WP_005063545.1|2330749_2331184_-|DUF779-domain-containing-protein
MPRASSDEGSPGESRILINRVELTPAAAELLASLVAKHGPVMFHQSGGCCDGSAPMCYPRGEFRVGASDVLLGEVSRDTPFWMSADQFEYWSHTHLTVDVVPGRGSGFSLEAPEGVRFLIRSRLFTDDEVLALANQPVRTGADG
>NZ_AP022621.1|WP_005063544.1|2328865_2330656_-|hypothetical-protein
MHVGIRTVAVAAVCGLCVGAGVDARAVRPNLSIAGTPTTRSVSSQAVSLASFSDLLAAAAPQNDAAAQMNSVGGGAVSSTDLIGTVAKLLAAPNITQSSVTPGINTAAVDTVDSPSSEPVDPPTGQPADPPAADEPAPPTNFPGERPAFGTPSYFAQLAFAVFHVVALPITVPVQFFLGSAEGVPTVIAAAINDLSGLLGQIPGLSPQQPTEPQPQQTAQSSSPLQKQAAAETGPTTDPEPPAEPLPTNFPGPRPAFGTPSYFAQLAFAVLHVLALPITVPVQAIIGKTEGVPSVIVAALNDLSSLLGQVPKLSAPVTDTKTTPQDSTSRQADKAAPTLDSASEKPETATSGADAKTSKIERNEHEGKTADKAAEAPKAEHETKPGAASEGTPKTDSAKEVVESKADPTKVVESKADPTKAVEPKADPTKVVEPKVDPAKVVEPKTDPAKAVEPKADTVAEPAKPESSKAEVAKPVTAKPETKVQPAKPESAGPVKVTRDSLKSTPGETGTTGGTKTTEGSKGSVTDSKTPAASTDTKVHDGLKPAVGAKPDKPADKPSTEKSSSEKSGSSSEGSSHSSESKSHSSEGKSHSGSKD
>NZ_AP022621.1|WP_005066010.1|2328129_2328876_+|peroxide-stress-protein-YaaA
MIVLLPPSETKHEGGDGPPLRLNELATPTLNPLREALVDELIALAAEPDACRQALGISASQDAEIQRNAELRISPTMPALHRYTGVLYDNLDVTSLRGASATRARERLAVGSALFGLLRADDPVPAYRLSASSKLPGKPTLAARWRPVLEPVLAELAAGELVVDLRSGSYAGLGRLPHAVTVDCLTEHPDGRRTVITHFNKAHKGKLARILAGSRAEPNDAASVATVARRAGLHVERDGNTLTIVVSP
>NZ_AP022621.1|WP_005063541.1|2327221_2328004_-|VOC-family-protein
MPTRDETPLGAPAWIDLASSDLEKSKAFYSALFGWTLQDAGPEYGGYINAHKDGKAVAGMITNNPEWNAPDAWTTYFATDDIDATLQKAVAHGGTNCLPPMEVPQLGYMALFADPAGAMVGLWQPLAHKGFQLVGEGGAPAWHELNTREYDRAVDFYTTVLGWNTKTEGDSADFRYACAQHDGAPIAGINDASVGQWALPEGVPAHWAVYFGTDDTDAGAAKATELGGVVLAPAQDTPYGRMALIRDTTGATFWLCSVDS
>NZ_AP022621.1|WP_005063540.1|2325989_2327195_+|DNA-polymerase-IV
MTGTASILHADLDSFYASVEQRDTPALRDRPVIVGGGVVLAASYEAKHCGVRTAMGGRQALRLCPHAVVVPPRFDAYSAASKLVFEVFRDTTPLVEPLSIDEAFLDVSGLLRISGAPRDIAAALRVEVRRRAGLPITVGIARTKFLAKVASRQGKPDGLLVVEPHEELSFLRPLPVQALWGVGSVTAEKLRVYGIRTVADVADLGESTLASMVGRAMGHQLHCLANNIDPRRVDGGRRRRSIGAQCALGRGPRADSEIDAIATQLMERIARRMRGTGRSCRTVVLRLRFGDYARATRSRTMPRPTTSTERLLSVARELVKDAGPLIKERGITLIGFSVSNFDPCGAAQLELPFSDAAENTLALDSTLDGLRNRFGTRSVTRANLLHGGGREEWGIPTFEDL
>NZ_AP022621.1|WP_005065999.1|2337023_2337467_-|SRPBCC-family-protein
MAAKLNSSIDVPLPPEEAWAHASDLRRFDEWLSVHTAWRSALPETLEKGTVIDSIVCVKGMYNRVRWTLQKYDPPTGLFLDGQGRGGVKVKLRVTISPKGSGSVVDFNLHLGGPAMFGPIGAVVAAALRSDIDASLAKFVQVFAAAP
>NZ_AP022621.1|WP_005102410.1|2337503_2338640_-|lipase
MLVLITAACARVEAEGVAPQPPSPPPGEVLSDVPLSLAPDLDAIADGHLIRYMSTSGATGTPTEVTGVVFAPKGEPPQAGWPIVSVGHGTTGLDDECAVSRAPDLRGYIWLVRNLSKRGWVVAITDYEGLGVPGPHPYLEPRSEGFNVIDAARAAVSLIPGASTKWAAIGASQGGQATWAASELAGNYASELEFVGSANLSPAADLTDMATHVGDGRYHWSQLSMMPTLLTGLSVTVPELRPENFLHGSFQDIPQDKALLLGCHNGLDPARSAAIGRLRAKDFHGTSPADPIVFAAALKRIALPLGPASGPMFVYAGGADRLIEAGWIHAAVRRACALGDTVQEVVSPGKGHVDPEGERLGVQWIADRFAGLPAPSNC
>NZ_AP022621.1|WP_005063556.1|2338662_2338878_-|antitoxin
MADFKGLIDKLKSLLAGNKDKVNEAVDKVGDTIDSKTGGKYSAVVDKVQDAAKSAVEKVEGAAAPKDGDAQ
>NZ_AP022621.1|WP_016341947.1|2338932_2339766_+|class-I-SAM-dependent-methyltransferase
MLVRVTDPVKITLTGAPETMLATLYGRAQDATSPNSVLHDHYAAEAVARIDYDFSKTKIKGTQAIGVALRARQLDDWTSEFLTAHREATVLHLACGLDTRVFRINPSETVRWVDVDYPDVIALRRALLPCREGDYRMIGSSVSEATWLDSIPADRPTLAVFEGLTMYLTEAEGQSLIRRITGRFPSGQLAFDCYGSIGIKLQKLVPAVRNAGATLHWGIDDPGQIEALHPGLRCVSDLRSTDVAGEEHLPLSGRIQMKVISHLPALRDIDRIMRFSF
>NZ_AP022621.1|WP_005063558.1|2339795_2342198_-|cation-translocating-P-type-ATPase
MATIEGLTISGLTAAEVAERVAQGKTNDVPSRAARSVSDIVRANVFTRINAILGVLLIIVLSTGSIINGAFGLLIIANSAVGIIQELRAKQTLDKLAIVGQTRPLVRRDGAATALAPNEVVLDDIIELGPGDQIVVDGEVIEESALEIDESLLTGEADAIEKTIGSQVLSGSFVVAGSGAYRATKVGREAYAAKLAEEASKFTLVHSELRNGINKILQFITYLLLPAGALIIYTQLFTTDDSWQESVLRMVGALVPMVPEGLVLMTSIAFAVGVIRLGRRQCLVQELPAIEGLARVDTVCADKTGTLTENGMRLADVRFPDRDGDEDALAVLAQLAADDPRPNASIAAIAEAYDTPPGWETTAIAPFSSAKKWSGASYGDHGNWVIGAPDVLLDPADAIATAAEEIGARGLRVLLLASAELSVDDAYAPGAVTPRALVVLEQKIRPDARETLDYFASQHVSIKVISGDNAVSVSAVAQTLGLTGAAVDARTLPTDTDKLAATLADATTFGRVRPDQKRAMVKALQSHGHTVAMTGDGVNDVLALKDADIGVAMGAGSSASRAVAQIVLLDNKFATLPYVVAEGRRVIGNIERVSNLFLTKTVYSVLLALTVGLAGLGSKIFHYGAVPFPFQPIHVTIAAWFTIGIPAFILSLAPNNERAQTGFVRRVMLSAIPSGLTVGIATFLSYLLARQILHVSGNSTQASTAALITELVAAVWVLAVVARPYQWWRVVLVALSGLGYVAIFAIPLARKAFMLDPGNLAVTGPALGIGIAAAAVIEAVWWLQGKWSGQPRHFWATGED
>NZ_AP022621.1|WP_016341946.1|2342315_2342993_+|class-I-SAM-dependent-methyltransferase
MTSNELPDWDATYQGKGELFQGEPPWNIGEPQPELAALIDAGKFHGTVLDVGCGHAETSLRLAALGHTTVGLDLSPTAIEAARAAAAERGLTNATFEVADITDFSGYDGRFNTIVDSTLFHSIPVEAREAYLRSISRAAAPDASYFVLVFAVGAFPPGIGPNAVTEDELRAAVEPYWAIDELSSAYIHSNIPEVIPGANFEMPVFHKDEKGRNKQPAFLLQAHKR
>NZ_AP022621.1|WP_005063561.1|2342989_2344096_-|MBL-fold-metallo-hydrolase
MSVRALWVGAGAAIASTWIGRALRDVPQTLGASKGRIAEVAKGSPQYRGGTFHNAEPARQFSPDAETTTVVWDVLTRRSVGTPKGQVPLAVPEFAGPPADLAATWFGHSSVLVEIDGYRVLTDPVWSDRCSPSRVVGPHRQHPVPVELSALPALDAVVISHDHYDHLDMDSIIALTRSQNAVFVVPLGVGAHLRGWGVSPARVIELDWDQSHQLGKLTLTCTQARHFSGRSIARNTTLWASWAFAGPKHKVFFGGDTGYTKAFKVIGDTYGPFDLTLLPVGAYNTSWADIHMNPEEAVQTHLDLATAQAPLLPIHWATFNLALHPWAEPIERVLAAAEEQGVTVVTPRPGQRADARRPAAPDDWWRLS
>NZ_AP022621.1|WP_005063562.1|2344092_2344824_-|enoyl-CoA-hydratase
MIGVTSDGPVTTIELQRPERRNAVTYELALAFAEEVKKAAETARAIVVTGQGTSFCAGADLSSGAPDPDKFADAWQHSIKSVDAADIPVIAAVNGPAIGAGVMLAMVADLRVVSETARFQFPVAKYGIALDNWSIRRLTSLVGYGRARAMLLAAEPLDAQTALQTGMANRIGELADAQAWAAELAGFAPLALKHAKRVLNDDGAFEDQWPEHKELFDKAWGSQDIIEAQVARIQKRPPNFQGA
>NZ_AP022621.1|WP_005116170.1|2344839_2345937_+|NAD(P)/FAD-dependent-oxidoreductase
MAPMTTVAVIGGGQAGIAAGYFLRRRGLEPLSRRQPADAPGHGFVILDHSPGPGGAWQFRWPTLTLDNTNRIYQLPGLPFDEMGAIRASTAMPRYFGEYEDRYALDVRRPVHVRAVRPARGGFTIDTSVGEFPVDGLINATGTWDKPFVPFVPGAGTFRGRQLHTHDYQRPEEFTGQHVLVVGGGISAVQLLIEIAGIDSVTTSWVTRREPVFVTDLTVDRLRAAVAGVDERSRRGEPQRSVVSATGLPWTAETAEAARRGVLTRRPMFSRITPTGVTWPDGSALEVDVILWCTGFRHALDHLAPLHLRNGRGGITMTGRLLTQVAGQPAIHLLGYGSSASTIGANRASRAAVVELMNYLEGRTA
>NZ_AP022621.1|WP_005063565.1|2345916_2346498_-|hypothetical-protein
MCAALGVGLLSGGAAVAHADPAFPDLSGFAVVPPDGFFVTNENSSVRSIHFSTPDGIGCMFRASPNMTPTSRQRLSCDGAVPGIPGDAPNAPNVPGIGGASANVPGLGGVNIPGVGTCPMGTVAQKGDGAFEISKGAWSCGTKPEAPLLNVGQKLTYGNVTCAVGAGSVTACQVVTGDQKHGFVLQPSGSTSF

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Crispr_ID: NZ_AP022621_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022621_2

4046331-4046459

Orphan

Consensus_repeat	Method
TTCCCGTGGTGGCTCCGATAGCGGCTCGCGGGGTGGTTGGGGCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022621_2

>merge|NZ_AP022621|2|4046331-4046459|CRISPRCasFinder
TTCCCGTGGTGGCTCCGATAGCGGCTCGCGGGGTGGTTGGGGCGATAACGGCGGCTCCCACGGTGGCTGGGGTGACAGCGGAAGTTCCCGTGGTGGCTCCGACAGCGGCTCGCGGGGTGGTTGGGGCGA

>NZ_AP022621|2|2|4046331-4046459|CRISPRCasFinder
TTCCCGTGGTGGCTCCGATAGCGGCTCGCGGGGTGGTTGGGGCGA	TAACGGCGGCTCCCACGGTGGCTGGGGTGACAGCGGAAG
TTCCCGTGGTGGCTCCGACAGCGGCTCGCGGGGTGGTTGGGGCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022621.1\|WP_016343471.1\|4059436_4060318_-\|cytochrome-c-biogenesis-protein-CcdA	unknown	unknown	gnl\|CDD\|223856
NZ_AP022621.1\|WP_016343472.1\|4058136_4059060_-\|M56-family-metallopeptidase	unknown	unknown	gnl\|CDD\|320685
NZ_AP022621.1\|WP_016343476.1\|4046662_4048003_+\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223936
NZ_AP022621.1\|WP_005064114.1\|4059056_4059419_-\|BlaI/MecI/CopY-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367747
NZ_AP022621.1\|WP_016343474.1\|4052596_4054966_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NZ_AP022621.1\|WP_030142800.1\|4048087_4049398_-\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|181738
NZ_AP022621.1\|WP_005071430.1\|4036642_4037446_-\|transglutaminase-family-protein	unknown	unknown	gnl\|CDD\|224224
NZ_AP022621.1\|WP_005064101.1\|4041773_4042673_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_AP022621.1\|WP_016343478.1\|4039864_4041292_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022621.1\|WP_005071417.1\|4057672_4058056_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NZ_AP022621.1\|WP_005064104.1\|4044184_4044754_+\|dCTP-deaminase	unknown	unknown	gnl\|CDD\|234753
NZ_AP022621.1\|WP_005101893.1\|4055058_4056879_-\|Hsp70-family-protein	unknown	unknown	gnl\|CDD\|223520
NZ_AP022621.1\|WP_005064102.1\|4042708_4043425_+\|L,D-transpeptidase-family-protein	unknown	unknown	gnl\|CDD\|226309
NZ_AP022621.1\|WP_016343479.1\|4037535_4038465_-\|formylglycine-generating-enzyme-family-protein	unknown	unknown	gnl\|CDD\|335469
NZ_AP022621.1\|WP_041927747.1\|4057060_4057660_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022621.1\|WP_016343475.1\|4049405_4052438_-\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|223325
NZ_AP022621.1\|WP_005064098.1\|4038509_4039805_-\|glycoside-hydrolase-family-27-protein	unknown	unknown	gnl\|CDD\|269893
NZ_AP022621.1\|WP_041927749.1\|4033971_4036479_-\|arylsulfatase	unknown	unknown	gnl\|CDD\|293749
NZ_AP022621.1\|WP_005064100.1\|4041370_4041784_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|283157
NZ_AP022621.1\|WP_005071425.1\|4043468_4044134_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226309

Protein	Function_ID	Function_description	E-value
NZ_AP022621.1\|WP_016343471.1\|4059436_4060318_-\|cytochrome-c-biogenesis-protein-CcdA	gnl\|CDD\|223856	COG0785, CcdA, Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones].	2.97521e-23
NZ_AP022621.1\|WP_016343472.1\|4058136_4059060_-\|M56-family-metallopeptidase	gnl\|CDD\|320685	cd07326, M56_BlaR1_MecR1_like, Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase. This family contains peptidase M56, which includes zinc metalloprotease domain in MecR1 as well as BlaR1. MecR1 is a transmembrane beta-lactam sensor/signal transducer protein that regulates the expression of an altered penicillin-binding protein PBP2a, which resists inactivation by beta-lactam antibiotics, in methicillin-resistant Staphylococcus aureus (MRSA). BlaR1 regulates the inducible expression of a class A beta-lactamase that hydrolytically destroys certain ?-lactam antibiotics in MRSA. Both, MecR1 and BlaR1, are transmembrane proteins that consist of four transmembrane helices, a cytoplasmic zinc protease domain, and the soluble C-terminal extracellular sensor domain, and are highly similar in sequence and function. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. All members contain the zinc metalloprotease motif (HEXXH). Homologs of this peptidase domain are also found in a number of other bacterial genome sequences, most of which are as yet uncharacterized.	3.76039e-31
NZ_AP022621.1\|WP_016343476.1\|4046662_4048003_+\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	gnl\|CDD\|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	0
NZ_AP022621.1\|WP_005064114.1\|4059056_4059419_-\|BlaI/MecI/CopY-family-transcriptional-regulator	gnl\|CDD\|367747	pfam03965, Penicillinase_R, Penicillinase repressor. The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.	2.20256e-26
NZ_AP022621.1\|WP_016343474.1\|4052596_4054966_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	7.64549e-16
NZ_AP022621.1\|WP_030142800.1\|4048087_4049398_-\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|181738	PRK09265, PRK09265, aminotransferase AlaT; Validated.	0
NZ_AP022621.1\|WP_005071430.1\|4036642_4037446_-\|transglutaminase-family-protein	gnl\|CDD\|224224	COG1305, COG1305, Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism].	1.01871e-16
NZ_AP022621.1\|WP_005064101.1\|4041773_4042673_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	7.28291e-21
NZ_AP022621.1\|WP_005071417.1\|4057672_4058056_-\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	3.80091e-14
NZ_AP022621.1\|WP_005064104.1\|4044184_4044754_+\|dCTP-deaminase	gnl\|CDD\|234753	PRK00416, dcd, deoxycytidine triphosphate deaminase; Reviewed.	8.44939e-97
NZ_AP022621.1\|WP_005101893.1\|4055058_4056879_-\|Hsp70-family-protein	gnl\|CDD\|223520	COG0443, DnaK, Molecular chaperone [Posttranslational modification, protein turnover, chaperones].	4.06726e-30
NZ_AP022621.1\|WP_005064102.1\|4042708_4043425_+\|L,D-transpeptidase-family-protein	gnl\|CDD\|226309	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown].	1.05021e-67
NZ_AP022621.1\|WP_016343479.1\|4037535_4038465_-\|formylglycine-generating-enzyme-family-protein	gnl\|CDD\|335469	pfam03781, FGE-sulfatase, Sulfatase-modifying factor enzyme 1. This domain is found in eukaryotic proteins required for post-translational sulfatase modification (SUMF1). These proteins are associated with the rare disorder multiple sulfatase deficiency (MSD). The protein product of the SUMF1 gene is FGE, formylglycine (FGly),-generating enzyme, which is a sulfatase. Sulfatases are enzymes essential for degradation and remodelling of sulfate esters, and formylglycine (FGly), the key catalytic in the active site, is unique to sulfatases. FGE is localized to the endoplasmic reticulum (ER) and interacts with and modifies the unfolded form of newly synthesized sulfatases. FGE is a single-domain monomer with a surprising paucity of secondary structure that adopts a unique fold which is stabilized by two Ca2+ ions. The effect of all mutations found in MSD patients is explained by the FGE structure, providing a molecular basis for MSD. A redox-active disulfide bond is present in the active site of FGE. An oxidized cysteine residue, possibly cysteine sulfenic acid, has been detected that may allow formulation of a structure-based mechanism for FGly formation from cysteine residues in all sulfatases. In Mycobacteria and Treponema denticola this enzyme functions as an iron(II)-dependent oxidoreductase.	7.26036e-80
NZ_AP022621.1\|WP_016343475.1\|4049405_4052438_-\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|223325	COG0247, GlpC, Fe-S oxidoreductase [Energy production and conversion].	1.9528e-88
NZ_AP022621.1\|WP_005064098.1\|4038509_4039805_-\|glycoside-hydrolase-family-27-protein	gnl\|CDD\|269893	cd14792, GH27, glycosyl hydrolase family 27 (GH27). GH27 enzymes occur in eukaryotes, prokaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-N-acetylgalactosaminidase, and 3-alpha-isomalto-dextranase. All GH27 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH27 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.	2.78834e-116
NZ_AP022621.1\|WP_041927749.1\|4033971_4036479_-\|arylsulfatase	gnl\|CDD\|293749	cd16025, PAS_like, Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.	0
NZ_AP022621.1\|WP_005064100.1\|4041370_4041784_+\|hypothetical-protein	gnl\|CDD\|283157	pfam05423, Mycobact_memb, Mycobacterium membrane protein. This family contains several membrane proteins from Mycobacterium species.	0.000638206
NZ_AP022621.1\|WP_005071425.1\|4043468_4044134_+\|hypothetical-protein	gnl\|CDD\|226309	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown].	3.84717e-43

>NZ_AP022621.1|WP_005064104.1|4044184_4044754_+|dCTP-deaminase
MLLSDRDIRAELDAGRLGIEPLDAALIQPSSIDVRLDSLFRVFNNTRYTHIDPKERQDELTSLVEPAEGEPFVLHPGEFVLGSTLEVCSLPDDLAGRLEGKSSLGRLGLLTHSTAGFIDPGFSGHITLELSNVANLPITLWPGMKIGQLCLLRLTSPAEHPYGSAGVGSKYQGQRGPTPSRSYQNFINP
>NZ_AP022621.1|WP_005071425.1|4043468_4044134_+|hypothetical-protein
MRPIRLLPLSLVLLAGACGATPVQPVAAVLPAPPPPWFADSVGAARQVVEVQGTGGTKAVVGTWQRKGDTWEPVERDLPSDVGSAGFTDVSSDDNPATPTGVFSLDYAFGTEPSVAHGLDYLQVDADDWWDGDPASPDYNTHQRCAESACTFDTSLSEELDGYPRAIVMGVNKSRVPGAGSAFFVHATDGGPSAGCVTLDDAALVRLIGWLRPGAVIAIRR
>NZ_AP022621.1|WP_005064102.1|4042708_4043425_+|L,D-transpeptidase-family-protein
MVKPLPNLEGFENNIGHDGTVFRLLTLPCAALLALATVLLAAPAGAEPFVPWFAQSVGNATQVIAVNGAGGSNAKIDVFQRNGSQWQTVSTGIPAHVGSAGFIDKAKEGASATPNGVYSLDWAFGTAPPPPSGLRYLQVGPNDWWDGDSNSPTYNTHQQCAKAECPFNTAQSENLPIPQYKHAIVMGVNKDRVPGGGSAFFVHSTDGGPTAGCVSLDDATLVKLIGWLRPGAVIAIKG
>NZ_AP022621.1|WP_005064101.1|4041773_4042673_-|alpha/beta-hydrolase
MDAELEEWKAAGHYFDYLGFDIFYRIEGSGPPLLLIHGYPFNSWDWALIWPTLVERFTVIAPDMIGMGFSDKPVQYGYSVLDHADMHEALLSYLGIERFHLLTHDLGNSVGQEMLARFEFEQQSRGRVPIDSVTWLNGGLFIEAYRPRIAQTLMSRTPLGDLVSRFQGTPVSRRIMDAAVSEMFGPDTKPSPRLLSLFQQVLEYNDGARVTHQVGRFINDRYDNRSRWVRAMRETAVPMRMIDGPIDPNSGLHMAERYLEVIHDPDVVLLDDNVGHWPQIEAPEAVLTHFLEHIDRITP
>NZ_AP022621.1|WP_005064100.1|4041370_4041784_+|hypothetical-protein
MTVRQLLIASAMACACALNFPAAAHADDKTVTYEVVSTTVTTANVQYWDGTEMQPADGVTLPWKVDATVGDISRGAKTPNHAEVKANWAATADPDSAVTVRIYLNDKVVCQSVTGTGETDCNYATFSTYLDTAPPKA
>NZ_AP022621.1|WP_016343478.1|4039864_4041292_-|hypothetical-protein
MAKTTSAQILEQTPIRPDYGVMSSVGGADLEDPVGDDSKRPGWDAATCVAFRYGTCYFGAFGLVVAVGLIPVILKGAGVDGPWSVIREIFHAARGPIAWIGEHLLGLRVQSAQVGSDSAFQWTALFCIACLALVATAIWTVLDRGRRRYDRLQPWVWAVLRLVLAAAMFYFGMAKVIPTQMPFVLNRLVEPYGNFSPTGVLWAQVGISPAYQMVLGLAEVFGGLLLLLPRTTAAGALVCVVDLTQVFLLNMTYDIRLKTVSSQLLLLSLFLLAPYARRLLTAFFTDRAVPAAATTQLFTRPRANRIALTAQVCLGMALLAAFGAQGWQQFTRPTPNLYGIWQVETFSAEGYSRDPLLTDKIRWRRVIFDRPFHVSAPVMMTVQRMDDSFEVYGGTIDPRRHFIDLSHRIELGTYKETPTRIRLTYWWPGQPDQMIVDGDDYAGHKIHLRVTRMDPASFPLVERGFNWVQETPYNR
>NZ_AP022621.1|WP_005064098.1|4038509_4039805_-|glycoside-hydrolase-family-27-protein
MSRGRRALILIMLAVIGIVATVLSVHIFRRQPQPGPAIAGLASTPPLGWNSWNVFGCNIDEQRIERTAQAMVSSGMRDAGYRYVVVDDCWFDPRRDASGELRANPARFPHGMKAVADFVHARGLLFGIYASPGEATCAQNGGSYPGRTGSRGHEIQDAQTFARWGVDYLKYDWCGPPADVDELVDSFTIMRDALRATGRPILYSINPNSGTVIPPSRYDSFTGVATMTRVSQDLVPAWDAIDAYDTSLGVVDALTNAAGPAFRCTPQPGFFCDYDMLVAGAPQVAGIDLPPLNAAESRAQLALWAEWGSPLIAGNDLTHMPEDIRALLINRDLLAIDQDSLRASATALAGSGGTIWTRPLGDGSTAIVIVNRDDAAQPFRAAFSALGLPKARRFDVLDVFSGQRSVQPLTYRTSLAAHDAMLLRVRAIGDQ
>NZ_AP022621.1|WP_016343479.1|4037535_4038465_-|formylglycine-generating-enzyme-family-protein
MEYSPRNRKLRETETAAVALTELVELPGGSFPMGCNVFYPEEMPERVSSVGPFAIERHPVTNAQFAEFVTQTGYVTVAERAPDPDMYPGASPDDLVPGAMTFRTTAGPVNLHDWQQWWDWVPGAYWRHPFGPGSDIDGAAEHPVVQVAYTDAAAYARWAGRRLPTEAEWEYAARGGSDTVYAWGDEVAPEGRLMANTWQGRFPYRNDGALGWHGTSPVGTFPANGFGLLDMIGNVWEWTSTRFQPGAGTPRSCCSPSDNPDPSVIQVLKGGSHLCAPEYCHRYRPAARSPQSQDSATTHIGFRCVENLA
>NZ_AP022621.1|WP_005071430.1|4036642_4037446_-|transglutaminase-family-protein
MRRDIRAQLDVDILEPSTLEFQVAVSPLTGAEVSEELSLELNGRRVEAQEVAGEHGNRIHRLPAERGNLKVSYTATILGQADEVPVEAADLSTYLRPSRYAEADKFFGFAAAEFGEHTDPAVLLEKVSSWVGARLTYSPGSSDPIDGAVDTLLSGAGVCRDYAHLVVALLRAVKVPARLVAVYAPGCDPMDFHAVAEAVVDNRWRVVDATCLAPRQTMVRITTGRDAADTAFLDNHGGQIVLNESIVAAVVDGELPEDHIDHLVSMR
>NZ_AP022621.1|WP_041927749.1|4033971_4036479_-|arylsulfatase
MRTPGDDAPEPEQKAERGRLTRRSMLGGIAAAGMGVAAASALVAGCDDDSSSRTDRSSAAEEANAGFDGKIELDVRDSKPDWTPYELKHAPDGAPNVLVVLFDDTGMATWSPYGGRVNMPTLQRLADNGLTYSQWHTTALCSPTRSCLLTGRNHHVNRFASITEGSDGYPGAAGRLPAQCATIGQVLQDNGYSTFWVGKNHNVPQEDVSCGGSKSEWPLQKGFDRYYGFLGGETNNWYPDLVEDNRFIEQPASPEQGYHLSKDLADQALRMLRDQRNTNPSKPWYMWFCPGANHAPHHSPAEYADKYRGKFDDGYEAYREWVLARMIDKGILPRETKLTPINPLPKDVAVEADSVRPWNTLNPDEKRLFSRMAEVFAGFSEYTDAQVGRVIDYLEQTGQLDNTIVFYCADNGASGEGSPNGSVNENKFFNGYPDDLAENMKYIDRLGTPDTYNHYPTGWAVAFSTPFQMFKRYSQFSGGTCDPLVIHWPKGIKAKGEVRHQYHHVTDIVPTVLDVAGLTMPETYRGVDQFPVNGVSMRYTFDDKDAATTKKRQYYAMLGTRGIWENGWKASALHAPISGKGHFDQDKWELFHVDEDRSESTDLADQHPDKLKALIDAWFEEADKNFVLPLDDRLSTELLTIERPQFEPRRNRYLYYPDASPVPEGVAVNIRGKSYKIVANTDISAQAQGVIFAHGSRFGGHVLFIKDGRLHYVYNFLGIKPEQEFISAPLTPGNRTLGVEFVRRDKGQYGESLGTANLYVDGKLAATGPMRTQVGTFTLAGDGLCVGYDSGDNVSPQYTNPGRFTGGTIKVVAVDVSDESFIDLEKEAQAAFARD
>NZ_AP022621.1|WP_016343476.1|4046662_4048003_+|UDP-glucose/GDP-mannose-dehydrogenase-family-protein
MRCTVFGTGYLGATHAACMAELGHEVLGVDIDPGKVAKLSSGDIPFYEPGLRKILQSNIASGRLRFTTSYAEAAEFADVHFLGVGTPQKKGEYGADLRHVHSVIDTLVPLLSRSAVIIGKSTVPVGTARELGQRAAGFAAAGVDVEVAWNPEFLREGYAVKDTLHPDRIVLGVQRDSDRAEKLVRELYGPILDEEVPFLVTDLETAELVKVSANAFLATKISFINAISEVCEAVGADVTTLADALGYDPRIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGASHALTFLREVDSINMRRRTRMVELATKACGGSLLGANVAVLGAAFKPESDDVRDSPALNVAGLLQLNGAAVNVYDPKALENSRRLFPTLNYATSVLEAADRADAVLLLTEWQEFVDFDPDALAKVVRTKVIVDGRNCLDAAKWVNAGWRVFCLGKRMEELAHA
>NZ_AP022621.1|WP_030142800.1|4048087_4049398_-|pyridoxal-phosphate-dependent-aminotransferase
MDSNATIETVSTDNLPIDVPPRVPGLSPRQHQRVFAQSTKLQDVLYEIRGPVHAHAARLEAEGHRILKLNIGNPAPFGFEAPDVIMRDIIQALPYAQGYSDSKGILPARRAVVTRYELVDGFPYLDVDDVFLGNGVSELITMTTQALLDNGDQVLIPAPDYPLWTAATSLAGGTAVHYLCDETNGWMPDIEDLESKITERTKALVIINPNNPTGAVYSREILTKMVELARKHQLLLLADEIYDKILYDDAEHISVASLAPDLLCFTFNGLSKAYRVAGYRSAWLAITGPKDHAASLLEGVNLLANMRLCPNVPAQHAIQVALGGHQSIEDLVLPGGRLLEQRDVAWTKLNEIPGVSCVKPQGALYAFPRLDPEVHHIHDDDQLVLDLLLNEKILLTQGTGFNWPEPDHLRIVTLPWARDLAVAIERLGNFLASYRQ
>NZ_AP022621.1|WP_016343475.1|4049405_4052438_-|4Fe-4S-dicluster-domain-containing-protein
MSTATITLGIIGVIFSLVAWGSFFGGVVKMVRVILSGQPDRTRFRPFLPRLKQLIVEVVAHTRMNKFRTVGWAHWLVMVGFLGGFPLYFESYGQTFNPEFHWPIIGDTFLWHLWDELLGIGTVIGIVTLIIIRQLNHPRKPERLSRFGGSNFFAAYTIEMIVLVEGLGMVLVKSGKIATFHNSHPSSDFFTMNVAQLLPESPIMVSVFAFIKMMSGGLFLLLVGRKLVWGVAWHRFAAFFNIYFKRNADGSVALGAAKPMMSGGKVLEMESADPDVDAFGAGKVEDFSWKDLLDVTTCTECGRCQSQCPAWNTGKPLSPKLLITSLRDHTYAKAPYLLAGEDKSKLSEAEIAEGERQLVGGEGAVIDHEVLWSCTTCGACVEQCPVDIEHVDHIIDMRRYQVLIESEFPGELAGLFKNLENKGNPWGQNAKDRLNWIEEVDFDVPVFGQDVDSFADFEYLFWVGCAGAYEDRAKKTTKAVAELLALAGTKFLVLGADETCTGDSARRAGNEFLFQQLAMQNIELLNSVFEGVEQKQRKIVVTCAHCFNALGNEYPQVGGDYQVVHHTQLLNRLVRDKKLVPVAPVSQDVTYHDPCYLGRHNKVYTAPRELIGASGAAITEMPRHGERSMCCGAGGARMWMEEQLGKRINIDRVDEALSTPASKIATGCPFCRVMLTDGVTARDDSAAVEVVDVAQLLLESVGRTEDIRKALPAKGTAAAAAAERAATKTAEPEPVVAEEEAPATTKTEAAAPAAEAKPVSGLGMATGAKRPGAKKAAAPAEAAPATEAAPAPVKGLGMATGARRPGAKKTAAETSTAEAPAATPTAEAAPAAPVKGLGMAAGAKRPGAKKATAETGAATPAAPASPPASQAPAAAAAPAPPVKGLGMAAGAKRPGAKKTAPAAPAAPAPEATAVPSESEAPATTETSAVAEPPVKGLGIAAGARRPGAKKAAPATESAPEPAQPAATASGPTEPATSAPKDEAPETGSTPEPPVKGLGIAPGARRPGRRN
>NZ_AP022621.1|WP_016343474.1|4052596_4054966_-|helix-turn-helix-transcriptional-regulator
MKVLVNGTAGSGKTFVLSRIREALGSAGTPAVNHVPEAAPGPNTGPFVIDDADSLTDRQLETLRAVVENDPAAIIVVAAAPRRNPALRALFQALERESPAITLGPVNATDIGRMSPLAAPFAEQIAAASGGVLALTTAAVERLGDPDPLQSALRAIDTRVDELLRRLSPMAQAAVLLMSLDPGIGASDVAAALALPDAADLVDGALASGLIAGPGHVAFAARVHGCAARLLGAARHLDLERSLLRTQLEMGSVSADLALALVAHGLRDLEVARLLSNWATTESDPLSAADLYRAALTAGAEPDPIRVPLAESLARAGDLAAAAAQADEALASTDPAQRTAGVRVAAAIACHNGDSGQAAALYSWLGADMDGLTALSASPVFVGTGQLTNGRKSLEDNVGAPPTTSATAMRNAALGVIASVEGRGQEALSLLGQAVTQQPSTSSFTPDSTVALAALTMLHSGDTARARSILTGAIRADRRHDVFGVRHRLLAAWIAMLSGDLSGAVQWLPGAEVELSRRDRLFAESLRTGIARRHGDTGPLRQHWQASMDALSAYSIDLYTLLPVGELWVAAARLRTLDVMTHHLDRAFAVLAHLGDPIAWSAPLRWAGVHAAILTNSPENLAPHGQALAAGAGSSTYARTLATAGRTWLRVLANHVDGEEVDSAARMLADTGLGWDATRLASQAALHANDPKVAAAMLALARDLRSPSAAADGESTPSSAAHSPTSTRLSEREREVAELLLRGLPYRDIGAQLFISAKTVEHHVARIRRRLGAESRSDMFSMLRAILTP
>NZ_AP022621.1|WP_005101893.1|4055058_4056879_-|Hsp70-family-protein
MANALGLSIGATQLVATPDDPQSQPVVRSSILTLHEDGPPEVGVPSQPGLTLTGFVGRVGDPVGIVAADGSVHRAEWALTEAMRVLIADAVSSANFTAPPVLSASIPAHWSPQTVNTLRDAIDRVPAFAPGGRQLKLIPDARAALESLAAGPGTPDRGVMVVCDLGGSGSSITLADAARGFQQIGQTLRFADFSGQQIDQMLLTQVLTDLNQDPEGTTSVGALTRLRDQCRLAKERLSGDTATSVPVQLPGITTDVRLTRAELEGHLRGPLSNLINAIQDTVERNGIHPANITAVASVGGGASIPLVTQQLSERMRVPVITAPQPQLAAARGVALLATRPDLPPQDATAMRPVEQPPGDATMMRPVPTGTGTFAAPVAAAASEEPELAWSQDDSAPDLAPLQETGYQSGYTVDLDDEYQGPTEATNARPELRFSHGPYADGDDYDDYPPLPWYRRPLVWFIAAAAVAGIAFTGMMVSLTSSESPAPATTTPSVNVVPSTGDAPAEPPPSPEPPPPPQTHTVTQSVQPPPPSPEPPPPPPPTTTTTTTPPTTTTTTTTTTTTTTTTTTTPPTTTTTQPTTTTTQPTSTSRPAITIPGLPPIPIGPRN
>NZ_AP022621.1|WP_041927747.1|4057060_4057660_+|hypothetical-protein
MGNNLLDFVMALVRDQDMAAQYAANPERVIADAHLDGVQPSDVSALIPVVSESMPSISQLAAHPTASDLTHAAQIPADNIWASGAAVSAFDSPFTAPTHDPSLDAGLHAATDAVTDLAPRQDAITVPDQFTAPTDSAMATIDQFQAPLQSTDGGFEPQQFGADAGGTGSADPGLHDPFFDQGHLGHHPGIDHDAGIDHF
>NZ_AP022621.1|WP_005071417.1|4057672_4058056_-|DoxX-family-protein
MIPTGARLVFGVIFLLEGTQKVFGWWSGSPTGSGHPEPFLNWPYWWAGVFELVLGTLLTVGLRTRLAAVLAAGMMAYAYFFEHLPVHWEPMQNGGAFAATFCWGLLLLAVTANDTRLSLDRVLARRA
>NZ_AP022621.1|WP_016343472.1|4058136_4059060_-|M56-family-metallopeptidase
MTVALVLMAGATLIGVAGPACLRPTVRPSLLPAAALAAWLGALLAFLVLTTLSATLLLFPHVLDTSGVRTLVGGCLSGTVPHSSFGTLVQLGISLLPLTILTRVAVVAIRSLRSARRCRARHFWMLQAATCRSGEVHWIDDPRPIAYSLGGARGAVVATHGVRHLGERQCAAVIEHEMAHIRGRHHVAVLCADIAAAALPMLPLMRRAPAMVRLMVELAADDAAARVHGPPTVHAALLAMSQSAVAVPGVLHMSSESVAVRLLWLRTQGTADRTPMGRARLMLGFALLPTTLAGSAVVALFRAYCTF
>NZ_AP022621.1|WP_005064114.1|4059056_4059419_-|BlaI/MecI/CopY-family-transcriptional-regulator
MRDMFGLGEREATIMELLWSVAEPVTVRDVLDRLERPLAYTTVMTVLDNLHNKGHVTREKVGRAFQYRAAETREAAAARMVREVLAASGDAEGVLLHFAGATSPEESTVLRRILRRGGLA
>NZ_AP022621.1|WP_016343471.1|4059436_4060318_-|cytochrome-c-biogenesis-protein-CcdA
MIDVGVLGALLGGVLTLVSPCSALLLPSFFAYSFDRTGLLLRRTGLFYLGMMTVLAPLGAGVGTIGALLTEYRSQVTTTGGLLMTTLGAAIIAGIGFRIGPAARLAARLDLSSALSVLLLGTVYALAGFCSGPLLGSVLTVAAIGSSPIYGALLMSLYSLGMAAPLFALAFAWGKLGLSRRRWIRGREIRIGRFRTHSTNLVSGGMFIAIGVFFLATDGTAALGGLTGSDTQYDVQARLQSLTAGLPNAAVALGIACAAFVVVLMRLLRARITAAGDARKRSDSTREDADDRR

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP022621_1	1.1\|2336683\|26\|NZ_AP022621\|CRISPRCasFinder	2336683-2336708	26	NZ_CP032323	Azospirillum brasilense strain MTCC4035 plasmid p2, complete sequence	418376-418401	5	0.808
NZ_AP022621_1	1.1\|2336683\|26\|NZ_AP022621\|CRISPRCasFinder	2336683-2336708	26	NZ_CP007795	Azospirillum brasilense strain Az39 plasmid AbAZ39_p2, complete sequence	678153-678178	5	0.808
NZ_AP022621_1	1.1\|2336683\|26\|NZ_AP022621\|CRISPRCasFinder	2336683-2336708	26	NZ_CP029333	Mycobacterium avium subsp. hominissuis strain MAC109 plasmid pMAC109a, complete sequence	54049-54074	6	0.769
NZ_AP022621_1	1.1\|2336683\|26\|NZ_AP022621\|CRISPRCasFinder	2336683-2336708	26	NC_022654	Mycobacterium kansasii ATCC 12478 plasmid pMK12478, complete sequence	143457-143482	6	0.769

1. spacer 1.1|2336683|26|NZ_AP022621|CRISPRCasFinder matches to NZ_CP032323 (Azospirillum brasilense strain MTCC4035 plasmid p2, complete sequence) position: , mismatch: 5, identity: 0.808

tggccccaaccaccctggccggggtt	CRISPR spacer
ccgccgcgaccaccctggccggggtc	Protospacer
. *** *.*****************.

2. spacer 1.1|2336683|26|NZ_AP022621|CRISPRCasFinder matches to NZ_CP007795 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p2, complete sequence) position: , mismatch: 5, identity: 0.808

tggccccaaccaccctggccggggtt	CRISPR spacer
ccgccgcgaccaccctggccggggtc	Protospacer
. *** *.*****************.

3. spacer 1.1|2336683|26|NZ_AP022621|CRISPRCasFinder matches to NZ_CP029333 (Mycobacterium avium subsp. hominissuis strain MAC109 plasmid pMAC109a, complete sequence) position: , mismatch: 6, identity: 0.769

tggccccaaccaccctggccggggtt	CRISPR spacer
gtgccccaaccaccctcgccgggcaa	Protospacer
  ************** ******

4. spacer 1.1|2336683|26|NZ_AP022621|CRISPRCasFinder matches to NC_022654 (Mycobacterium kansasii ATCC 12478 plasmid pMK12478, complete sequence) position: , mismatch: 6, identity: 0.769

tggccccaaccaccctggccggggtt	CRISPR spacer
gtgccccaaccaccctcgccgggcaa	Protospacer
  ************** ******

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

447409 : 455936

uncultured_Mediterranean_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_025982461.1\|447409_448663_+	protein translocase subunit SecF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.5e-22	28.6
WP_016342806.1\|448662_450339_+	hypothetical protein	NA	NA	NA	NA
WP_016342805.1\|450335_450869_+	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	1.1e-14	36.4
WP_005057565.1\|450899_453266_+	RelA/SpoT family protein	A0A291L9W9	Bordetella_phage	1.8e-13	38.4
WP_016342804.1\|453356_454226_-	class A beta-lactamase	A0A077SL40	Escherichia_phage	5.7e-42	38.7
WP_005057567.1\|454227_455151_-	peptidylprolyl isomerase	A0A1V0SCU1	Indivirus	1.1e-08	31.6
WP_005057568.1\|455264_455936_+	MBL fold metallo-hydrolase	A0A1X9I5D3	Streptococcus_phage	4.9e-17	31.1

DBSCAN-SWA_2

1670992 : 1711658

Mycobacterium_phage(84.0%)

capsid,transposase,portal,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041927470.1\|1670992_1672228_+\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	1.2e-82	44.6
WP_005060038.1\|1672579_1673383_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_025982906.1\|1673361_1674039_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_016342279.1\|1674165_1675116_+	diiron oxygenase	NA	NA	NA	NA
WP_005099072.1\|1675154_1676681_-	DUF853 family protein	A0A248XCZ8	Klebsiella_phage	3.6e-60	37.7
WP_005099075.1\|1676694_1677435_+	oligoribonuclease	M4M9I5	Vibrio_phage	2.3e-23	39.0
WP_016342278.1\|1678081_1678969_+	DivIVA domain-containing protein	NA	NA	NA	NA
WP_005060026.1\|1679038_1680259_-	L,D-transpeptidase family protein	NA	NA	NA	NA
WP_041927631.1\|1680555_1680831_+	WXG100 family type VII secretion target	NA	NA	NA	NA
WP_016342277.1\|1680820_1681144_+	WXG100 family type VII secretion target	NA	NA	NA	NA
WP_041927906.1\|1681171_1682635_+	hypothetical protein	NA	NA	NA	NA
WP_016342275.1\|1682631_1683150_+	hypothetical protein	NA	NA	NA	NA
WP_041927630.1\|1683150_1683522_+	YbaB/EbfC family nucleoid-associated protein	NA	NA	NA	NA
WP_016342274.1\|1683609_1683936_-	hypothetical protein	NA	NA	NA	NA
WP_016342273.1\|1683974_1684280_-	hypothetical protein	A0A1D8EQ56	Mycobacterium_phage	3.8e-09	43.4
WP_016342272.1\|1684318_1684696_-	DUF2746 domain-containing protein	NA	NA	NA	NA
WP_041927470.1\|1684935_1686171_-\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	1.2e-82	44.6
WP_079276780.1\|1686244_1686436_-	hypothetical protein	A0A222ZRJ5	Mycobacterium_phage	1.6e-05	61.5
WP_016342270.1\|1686616_1686937_+	hypothetical protein	R4TBK1	Mycobacterium_phage	6.5e-12	41.5
WP_016342268.1\|1687167_1687815_-	HNH endonuclease	A0A076YKH2	Mycobacterium_phage	6.6e-19	60.0
WP_041927904.1\|1687811_1688939_-	hypothetical protein	S5W0N6	Mycobacterium_phage	1.7e-118	57.6
WP_041927903.1\|1689273_1690188_-	hypothetical protein	A0A2P1CCW0	Mycobacterium_phage	1.2e-55	43.3
WP_016342265.1\|1690238_1690679_-	hypothetical protein	NA	NA	NA	NA
WP_016342264.1\|1690681_1692127_-	M15 family metallopeptidase	A0A249XQG4	Mycobacterium_phage	9.1e-162	62.1
WP_016342262.1\|1692260_1692644_-	hypothetical protein	A0A222ZQF4	Mycobacterium_phage	1.6e-41	68.5
WP_016342261.1\|1692659_1693814_-	hypothetical protein	NA	NA	NA	NA
WP_016342260.1\|1693814_1694015_-	hypothetical protein	NA	NA	NA	NA
WP_005110315.1\|1696455_1697541_-\|tail	tail protein	A0A068F8L3	Mycobacterium_phage	1.4e-151	67.8
WP_041927901.1\|1697533_1697971_-	hypothetical protein	A0A068F2D2	Mycobacterium_phage	7.5e-35	51.8
WP_016342257.1\|1698066_1699863_-	hypothetical protein	A0A068F4H3	Mycobacterium_phage	5.9e-235	62.5
WP_016342256.1\|1699865_1700969_-	hypothetical protein	A0A068F3C3	Mycobacterium_phage	3.5e-153	67.9
WP_016342255.1\|1700968_1704967_-\|tail	phage tail tape measure protein	A0A068F1L4	Mycobacterium_phage	1.2e-293	59.9
WP_005067420.1\|1704977_1705289_-	hypothetical protein	A0A068F4G7	Mycobacterium_phage	4.0e-14	43.7
WP_016342254.1\|1705405_1705672_-	hypothetical protein	A0A068F4G7	Mycobacterium_phage	2.9e-13	44.7
WP_005067417.1\|1705766_1706354_-	hypothetical protein	A0A068F8K4	Mycobacterium_phage	1.6e-69	67.2
WP_016342253.1\|1706420_1706798_-	hypothetical protein	NA	NA	NA	NA
WP_016342252.1\|1706797_1707064_-	hypothetical protein	A0A068F3C1	Mycobacterium_phage	6.8e-15	51.2
WP_041927629.1\|1707063_1707291_-	hypothetical protein	G8I4C3	Mycobacterium_phage	7.4e-10	50.0
WP_016342250.1\|1707783_1708692_-\|capsid	phage major capsid protein	A0A221J736	Mycobacterium_phage	4.4e-122	76.9
WP_041927628.1\|1708748_1709279_-	DUF4355 domain-containing protein	A0A2R4AQA8	Mycobacterium_phage	3.7e-28	47.4
WP_079276779.1\|1710710_1711658_-\|portal	phage portal protein	Q9ZX72	Mycobacterium_phage	1.1e-102	68.2

DBSCAN-SWA_3

1719650 : 1734434

Mycobacterium_phage(68.75%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_005110295.1\|1719650_1720067_-	hypothetical protein	A0A068F2M6	Mycobacterium_phage	6.3e-23	50.4
WP_016342242.1\|1720311_1721007_-	hypothetical protein	A0A0A1ENE4	Mycobacterium_phage	1.3e-89	71.7
WP_016342241.1\|1722364_1723189_-	hypothetical protein	S5VVU3	Mycobacterium_phage	7.4e-76	54.3
WP_016342240.1\|1723195_1724458_-	glycosyltransferase	G8I6V8	Mycobacterium_virus	4.2e-70	72.6
WP_041927897.1\|1724587_1724869_+	DUF732 domain-containing protein	NA	NA	NA	NA
WP_016342238.1\|1725400_1725685_-	hypothetical protein	A0A059VG69	Mycobacterium_phage	3.7e-27	68.2
WP_051223592.1\|1725898_1726141_-	hypothetical protein	A0A068F4K6	Mycobacterium_phage	2.0e-05	40.3
WP_016342236.1\|1726179_1726524_-	hypothetical protein	NA	NA	NA	NA
WP_016342235.1\|1726561_1726891_-	hypothetical protein	A0A088FQ47	Mycobacterium_phage	2.2e-15	44.4
WP_016342232.1\|1728245_1728542_-	hypothetical protein	NA	NA	NA	NA
WP_051223590.1\|1728926_1729298_-	HNH endonuclease	A0A2I7RT07	Vibrio_phage	1.5e-15	45.5
WP_016342229.1\|1729630_1729894_+	HicA family toxin-antitoxin system toxin component	A0A2P1A0R7	Gordonia_phage	9.8e-06	56.8
WP_016342228.1\|1729890_1730250_+	type II toxin-antitoxin system HicB family antitoxin	NA	NA	NA	NA
WP_016342226.1\|1730527_1731190_-	hypothetical protein	A0A2L0HK00	Mycobacterium_phage	1.1e-48	46.2
WP_016342225.1\|1731186_1731624_-	DUF4326 domain-containing protein	A0A142KC74	Gordonia_phage	9.8e-27	46.7
WP_158022857.1\|1731945_1732236_-	hypothetical protein	NA	NA	NA	NA
WP_016342223.1\|1732232_1732475_-	hypothetical protein	G1D3X4	Mycobacterium_virus	1.8e-09	53.1
WP_016342222.1\|1732513_1732801_-	WhiB family transcriptional regulator	A0A2P1JRB7	Mycobacterium_phage	1.1e-10	37.8
WP_016342221.1\|1732800_1733118_-	WhiB family transcriptional regulator	A0A2P1JRB7	Mycobacterium_phage	4.2e-11	44.2
WP_158022855.1\|1733298_1733514_-	hypothetical protein	NA	NA	NA	NA
WP_016342219.1\|1733782_1734004_-	hypothetical protein	A0A068F4K6	Mycobacterium_phage	6.5e-11	51.3
WP_158022853.1\|1734000_1734174_-	hypothetical protein	NA	NA	NA	NA
WP_041927619.1\|1734170_1734434_-	hypothetical protein	A0A2D1G9M8	Mycobacterium_phage	5.5e-09	40.0

DBSCAN-SWA_4

2568906 : 2578830

Mycobacterium_phage(72.73%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016341886.1\|2568906_2569722_+	phage antirepressor KilAC domain-containing protein	A0A159B6D6	Gordonia_phage	6.3e-51	45.0
WP_016341885.1\|2569826_2570213_+	hypothetical protein	NA	NA	NA	NA
WP_016341884.1\|2570209_2570530_+	hypothetical protein	NA	NA	NA	NA
WP_016341883.1\|2570529_2570817_+	hypothetical protein	NA	NA	NA	NA
WP_016341882.1\|2571016_2571910_+	PD-(D/E)XK nuclease-like domain-containing protein	A0A2D1G8R5	Mycobacterium_phage	1.1e-77	50.3
WP_016341881.1\|2571906_2573028_+	hypothetical protein	A0A2P1CGD3	Mycobacterium_phage	7.2e-98	69.3
WP_005123095.1\|2573030_2573372_+	hypothetical protein	G8I4S2	Mycobacterium_phage	1.5e-35	68.1
WP_016341880.1\|2573399_2574236_+	DUF2303 family protein	G8I4S3	Mycobacterium_phage	3.5e-105	65.8
WP_016341879.1\|2574263_2574794_+	hypothetical protein	A0A1D8ERW9	Mycobacterium_phage	1.4e-38	51.4
WP_016341878.1\|2574790_2575207_+	hypothetical protein	NA	NA	NA	NA
WP_016341877.1\|2575203_2575740_+	hypothetical protein	A0A142F2K5	Mycobacterium_phage	5.2e-46	56.6
WP_016341876.1\|2575736_2576756_+	site-specific DNA-methyltransferase	A0A166YCK5	Gordonia_phage	3.6e-120	61.5
WP_051223575.1\|2577141_2577471_+	hypothetical protein	Q853R9	Mycobacterium_phage	2.3e-20	46.6
WP_016341873.1\|2577470_2577839_+	hypothetical protein	G8I4T1	Mycobacterium_phage	2.0e-52	81.0
WP_041927565.1\|2577918_2578830_+	hypothetical protein	A0A1B3B1T0	Gordonia_phage	1.3e-41	62.6

DBSCAN-SWA_5

2586214 : 2601743

Mycobacterium_phage(86.67%)

protease,tail,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041927847.1\|2586214_2586526_+	hypothetical protein	A0A2H4PD32	Mycobacterium_phage	1.1e-29	62.1
WP_016341863.1\|2586522_2586921_+	hypothetical protein	A0A088F7V7	Mycobacterium_phage	3.2e-16	53.3
WP_016341862.1\|2586898_2587291_+	hypothetical protein	A0A1D8EX45	Mycobacterium_phage	5.7e-50	73.4
WP_016341861.1\|2587287_2587740_+	AAA family ATPase	A0A1D8EX78	Mycobacterium_phage	1.3e-53	66.7
WP_016341860.1\|2587900_2588302_+	hypothetical protein	A0A023ZWK1	Mycobacterium_phage	1.0e-06	34.0
WP_041927552.1\|2588450_2589863_+\|terminase	terminase	R4TCB6	Mycobacterium_phage	1.9e-151	56.8
WP_016341858.1\|2589877_2591326_+	hypothetical protein	A0A249XTF7	Mycobacterium_phage	6.3e-171	66.0
WP_016341857.1\|2591319_2592573_+\|protease	ATP-dependent Clp protease proteolytic subunit	A0A1B3AZ47	Gordonia_phage	1.9e-86	51.3
WP_005070916.1\|2592576_2592954_+	hypothetical protein	W8EH90	Mycobacterium_phage	6.2e-46	82.4
WP_016341856.1\|2592970_2593882_+	hypothetical protein	A0A2K9VEV5	Mycobacterium_phage	3.4e-138	80.7
WP_016341855.1\|2593881_2594331_+	hypothetical protein	NA	NA	NA	NA
WP_016341854.1\|2594335_2594698_+	hypothetical protein	A0A218M9J6	Mycobacterium_phage	1.6e-30	57.5
WP_016341853.1\|2594697_2595105_+	hypothetical protein	NA	NA	NA	NA
WP_016341852.1\|2595104_2595464_+	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_016341851.1\|2595463_2595874_+	hypothetical protein	NA	NA	NA	NA
WP_016341850.1\|2595971_2597051_+	hypothetical protein	A0A2H4PED2	Mycobacterium_phage	9.5e-63	46.1
WP_016341849.1\|2597150_2597612_+	hypothetical protein	A0A0A7RVK9	Mycobacterium_phage	1.8e-26	42.1
WP_016341848.1\|2597724_2598036_+	hypothetical protein	A0A2P1JR40	Mycobacterium_phage	7.2e-24	62.8
WP_016341847.1\|2598050_2601743_+\|tail	phage tail tape measure protein	Q854Y3	Mycobacterium_virus	1.8e-193	40.1

DBSCAN-SWA_6

3478269 : 3486796

Mycobacterium_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_005064635.1\|3478269_3478947_+	response regulator transcription factor	W8CYM9	Bacillus_phage	4.4e-26	31.4
WP_005072025.1\|3479026_3480478_-	HAMP domain-containing histidine kinase	Q8QKV4	Ectocarpus_siliculosus_virus	2.9e-06	33.6
WP_016343750.1\|3480498_3480948_-	hypothetical protein	NA	NA	NA	NA
WP_016343749.1\|3481239_3481542_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_005064639.1\|3481708_3482557_-	N-acetylmuramoyl-L-alanine amidase	A0A2D1GEV9	Mycobacterium_phage	2.9e-67	56.1
WP_163926256.1\|3482985_3484335_+	LysM peptidoglycan-binding domain-containing protein	A0A1W6JL93	Lactococcus_phage	3.0e-05	47.3
WP_005082750.1\|3484383_3485196_-	DUF1906 domain-containing protein	A0A2D1GEF2	Gordonia_phage	3.1e-50	49.1
WP_041927778.1\|3485323_3486796_-	serine hydrolase	A0A1J0GRK9	Mycobacterium_phage	3.6e-12	28.5

DBSCAN-SWA_7

4923138 : 4953169

Mycobacterium_phage(59.26%)

capsid,tail,portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_005099947.1\|4923138_4924143_-	hypothetical protein	A0A2P1JR68	Mycobacterium_phage	2.4e-105	54.6
WP_041927977.1\|4924145_4924919_-	N-acetylmuramoyl-L-alanine amidase	A0A1U9WRQ3	Mycobacterium_phage	3.2e-105	71.7
WP_016343116.1\|4925443_4925689_-	hypothetical protein	G1JWF1	Mycobacterium_phage	1.2e-05	34.4
WP_016343115.1\|4925706_4926369_-	hypothetical protein	NA	NA	NA	NA
WP_005100057.1\|4926369_4926678_-	hypothetical protein	A0A2P1JT61	Mycobacterium_phage	4.8e-20	63.4
WP_016343114.1\|4926711_4927347_-	collagen-like protein	G9FHZ1	Nocardia_phage	8.1e-14	65.5
WP_016343113.1\|4927363_4927660_-	hypothetical protein	NA	NA	NA	NA
WP_016343112.1\|4927652_4928033_-	hypothetical protein	NA	NA	NA	NA
WP_041927975.1\|4928029_4928371_-	hypothetical protein	A0A2K9VEW7	Mycobacterium_phage	2.4e-28	58.9
WP_016343110.1\|4928376_4929765_-	hypothetical protein	I6X329	Mycobacteriophage	2.3e-13	34.2
WP_005094140.1\|4929764_4930874_-	hypothetical protein	A0A068F8L3	Mycobacterium_phage	2.6e-92	48.8
WP_005102329.1\|4930870_4931356_-	hypothetical protein	Q9ZX57	Mycobacterium_phage	9.6e-15	36.8
WP_079276868.1\|4931355_4933020_-	hypothetical protein	S5XYP0	Mycobacterium_phage	2.2e-183	55.8
WP_005102507.1\|4933077_4934307_-	hypothetical protein	M4W8F3	Mycobacterium_phage	2.9e-68	38.3
WP_174255653.1\|4934303_4937657_-\|tail	tail tape measure protein	A0A068F1L4	Mycobacterium_phage	3.7e-73	44.1
WP_005098361.1\|4937646_4937976_-	hypothetical protein	S5Z5T8	Mycobacterium_phage	1.3e-15	56.7
WP_016343107.1\|4938080_4938536_-	hypothetical protein	NA	NA	NA	NA
WP_016343106.1\|4938734_4939412_-	hypothetical protein	S5YN28	Mycobacterium_phage	2.9e-41	45.1
WP_016343105.1\|4939470_4939878_-	hypothetical protein	NA	NA	NA	NA
WP_005101360.1\|4939874_4940171_-	hypothetical protein	NA	NA	NA	NA
WP_016343104.1\|4940167_4940515_-	hypothetical protein	A0A142KAW9	Gordonia_phage	3.2e-12	38.7
WP_158022870.1\|4940511_4940928_-	DUF1320 family protein	A0A166XYS3	Gordonia_phage	1.4e-22	46.2
WP_016343102.1\|4940869_4941172_-	hypothetical protein	NA	NA	NA	NA
WP_016343101.1\|4941171_4942209_-\|capsid	major capsid protein	A0A166XYQ6	Gordonia_phage	1.1e-121	63.9
WP_016343100.1\|4942223_4942598_-	hypothetical protein	A0A2P1A0L4	Gordonia_phage	2.4e-45	72.4
WP_005100030.1\|4942642_4943200_-	hypothetical protein	A0A166XYP9	Gordonia_phage	1.1e-17	38.7
WP_016343099.1\|4943345_4944251_-	hypothetical protein	A0A088FUW7	Mycobacterium_phage	1.2e-79	54.2
WP_016343098.1\|4944231_4945710_-\|portal	phage portal protein	A0A2P1A0M6	Gordonia_phage	1.6e-132	51.9
WP_016343097.1\|4945710_4947558_-	hypothetical protein	A0A1I9SBW6	Mycobacterium_phage	5.1e-141	53.3
WP_016343096.1\|4947565_4947817_-	hypothetical protein	NA	NA	NA	NA
WP_131809300.1\|4947987_4948182_-	hypothetical protein	NA	NA	NA	NA
WP_016343095.1\|4948178_4948457_-	HNH endonuclease	A0A1D8EQ93	Mycobacterium_phage	2.7e-22	58.0
WP_016343094.1\|4948453_4948642_-	hypothetical protein	NA	NA	NA	NA
WP_016343093.1\|4948647_4948788_-	hypothetical protein	NA	NA	NA	NA
WP_005100616.1\|4948784_4949021_-	hypothetical protein	G9FH24	Rhodococcus_phage	2.3e-14	57.1
WP_005094086.1\|4949148_4949826_-	hypothetical protein	G9FH23	Rhodococcus_phage	5.1e-22	38.8
WP_016343092.1\|4949827_4950241_-	hypothetical protein	NA	NA	NA	NA
WP_016343091.1\|4950237_4950744_-	hypothetical protein	NA	NA	NA	NA
WP_016343090.1\|4950740_4951232_-	endonuclease VII domain-containing protein	A0A220NQC3	Rhodococcus_phage	7.9e-33	55.9
WP_016343089.1\|4951495_4953169_-	bifunctional DNA primase/polymerase	S5Y832	Mycobacterium_phage	5.4e-81	44.0

DBSCAN-SWA_8

5001400 : 5010743

Bacillus_phage(33.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016343040.1\|5001400_5002285_+	SDR family oxidoreductase	W8CYX9	Bacillus_phage	2.3e-06	35.1
WP_005056589.1\|5002281_5003103_-	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	2.9e-80	55.2
WP_005103245.1\|5003125_5003740_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_016891234.1\|5003856_5004405_+	NAD(P)H-dependent oxidoreductase	NA	NA	NA	NA
WP_041927470.1\|5004795_5006031_+\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	1.2e-82	44.6
WP_005056596.1\|5007866_5008109_+	redoxin NrdH	V5UN81	Mycobacterium_phage	1.8e-22	67.5
WP_016343037.1\|5008137_5008608_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A217ER62	Bacillus_phage	1.5e-09	30.3
WP_005069911.1\|5008604_5010743_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	V9VI16	Lactococcus_phage	1.5e-208	51.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_AP022622

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_AP022621

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection