CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP048599	Helicobacter pylori strain GCT 97 chromosome, complete genome	3 crisprs	cas2,DEDDh	4	2	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP048599_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048599_1

8398-8630

Orphan

Consensus_repeat	Method
CAAATAAGAGTGAGATAGAGTTAGAACAAGAAAGACAGAAGACA	CRT

3 spacers

The CRISPR arrays of NZ_CP048599_1

>merge|NZ_CP048599|1|8398-8630|CRT
CAAATAAGAGTGGGATAGAGTTAGAACAAGAAAGACAGAAAACAGAACAAGAAAGACAGAAGACAAATAAGAGTGAGATAGAGTTAGAACAAGAAAGACAGAAGACAAATAAGAGTGGGATAGAACTCGCTAATAGTCAAATAAAAGCAGAACAAGAAAGACAGAAGACAGAACAAGAAAAACAAAAAGCAAATAAGAGTGAGATAGAGTTAGAACAAGAAAAACAAAAGACA

>NZ_CP048599|1|1|8398-8630|CRT
CAAATAAGAGTGGGATAGAGTTAGAACAAGAAAGACAGAAAACA	GAACAAGAAAGACAGAAGA
CAAATAAGAGTGAGATAGAGTTAGAACAAGAAAGACAGAAGACA	AATAAGAGTGGGATAGAAC
TCGCTAATAGTCAAATAAAAGCAGAACAAGAAAGACAGAAGACA	GAACAAGAAAAACAAAAAG
CAAATAAGAGTGAGATAGAGTTAGAACAAGAAAAACAAAAGACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048599.1\|WP_163562675.1\|18129_18702_+\|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl\|CDD\|184538
NZ_CP048599.1\|WP_077657577.1\|5462_7895_+\|pyruvate,-water-dikinase	unknown	unknown	gnl\|CDD\|235809
NZ_CP048599.1\|WP_163562676.1\|18732_20595_+\|molecular-chaperone-DnaK	unknown	unknown	gnl\|CDD\|234715
NZ_CP048599.1\|WP_001941583.1\|2639_3251_-\|translation-initiation-factor-IF-3	unknown	unknown	gnl\|CDD\|234582
NZ_CP048599.1\|WP_078243657.1\|175_607_-\|DUF1104-domain-containing-protein	unknown	unknown	gnl\|CDD\|368949
NZ_CP048599.1\|WP_163562672.1\|10258_12469_-\|type-I-DNA-topoisomerase	unknown	unknown	gnl\|CDD\|235516
NZ_CP048599.1\|WP_163562671.1\|9339_10266_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|223803
NZ_CP048599.1\|WP_163562673.1\|14239_16123_+\|motility-associated-factor-glycosyltransferase-family-protein	unknown	unknown	gnl\|CDD\|225324
NZ_CP048599.1\|WP_163562674.1\|17299_18130_+\|HrcA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|235174
NZ_CP048599.1\|WP_000750214.1\|959_1820_-\|outer-membrane-protein	unknown	unknown	gnl\|CDD\|280099
NZ_CP048599.1\|WP_001125542.1\|2464_2659_-\|50S-ribosomal-protein-L35	unknown	unknown	gnl\|CDD\|234676
NZ_CP048599.1\|WP_163562670.1\|3247_5086_-\|threonine--tRNA-ligase	unknown	unknown	gnl\|CDD\|237050
NZ_CP048599.1\|WP_123946704.1\|16133_16430_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048599.1\|WP_163562677.1\|21490_22408_+\|cysteine-synthase-family-protein	unknown	unknown	gnl\|CDD\|107204
NZ_CP048599.1\|WP_000010011.1\|12634_14179_+\|flagellin-B	unknown	unknown	gnl\|CDD\|237440
NZ_CP048599.1\|WP_097714748.1\|16450_17089_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|180279
NZ_CP048599.1\|WP_001264156.1\|2019_2370_-\|50S-ribosomal-protein-L20	unknown	unknown	gnl\|CDD\|179959

Protein	Function_ID	Function_description	E-value
NZ_CP048599.1\|WP_163562675.1\|18129_18702_+\|nucleotide-exchange-factor-GrpE	gnl\|CDD\|184538	PRK14149, PRK14149, heat shock protein GrpE; Provisional.	2.90268e-98
NZ_CP048599.1\|WP_077657577.1\|5462_7895_+\|pyruvate,-water-dikinase	gnl\|CDD\|235809	PRK06464, PRK06464, phosphoenolpyruvate synthase; Validated.	0
NZ_CP048599.1\|WP_163562676.1\|18732_20595_+\|molecular-chaperone-DnaK	gnl\|CDD\|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NZ_CP048599.1\|WP_001941583.1\|2639_3251_-\|translation-initiation-factor-IF-3	gnl\|CDD\|234582	PRK00028, infC, translation initiation factor IF-3; Reviewed.	1.16167e-74
NZ_CP048599.1\|WP_078243657.1\|175_607_-\|DUF1104-domain-containing-protein	gnl\|CDD\|368949	pfam06518, DUF1104, Protein of unknown function (DUF1104). This family consists of several hypothetical proteins of unknown function which appear to be found largely in Helicobacter pylori.	3.00545e-24
NZ_CP048599.1\|WP_163562672.1\|10258_12469_-\|type-I-DNA-topoisomerase	gnl\|CDD\|235516	PRK05582, PRK05582, type I DNA topoisomerase.	0
NZ_CP048599.1\|WP_163562671.1\|9339_10266_-\|radical-SAM-protein	gnl\|CDD\|223803	COG0731, COG0731, Fe-S oxidoreductases [Energy production and conversion].	2.09608e-86
NZ_CP048599.1\|WP_163562673.1\|14239_16123_+\|motility-associated-factor-glycosyltransferase-family-protein	gnl\|CDD\|225324	COG2604, COG2604, Uncharacterized protein conserved in bacteria [Function unknown].	0
NZ_CP048599.1\|WP_163562674.1\|17299_18130_+\|HrcA-family-transcriptional-regulator	gnl\|CDD\|235174	PRK03911, PRK03911, HrcA family transcriptional regulator.	1.56446e-121
NZ_CP048599.1\|WP_000750214.1\|959_1820_-\|outer-membrane-protein	gnl\|CDD\|280099	pfam01856, HP_OMP, Helicobacter outer membrane protein. This family seems confined to Helicobacter. It is predicted to be an outer membrane protein based on its pattern of alternating hydrophobic amino acids similar to porins.	4.51995e-49
NZ_CP048599.1\|WP_001125542.1\|2464_2659_-\|50S-ribosomal-protein-L35	gnl\|CDD\|234676	PRK00172, rpmI, 50S ribosomal protein L35; Reviewed.	1.81419e-15
NZ_CP048599.1\|WP_163562670.1\|3247_5086_-\|threonine--tRNA-ligase	gnl\|CDD\|237050	PRK12305, thrS, threonyl-tRNA synthetase; Reviewed.	0
NZ_CP048599.1\|WP_163562677.1\|21490_22408_+\|cysteine-synthase-family-protein	gnl\|CDD\|107204	cd01561, CBS_like, CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.	2.57481e-138
NZ_CP048599.1\|WP_000010011.1\|12634_14179_+\|flagellin-B	gnl\|CDD\|237440	PRK13588, PRK13588, flagellin B; Provisional.	0
NZ_CP048599.1\|WP_097714748.1\|16450_17089_-\|hypothetical-protein	gnl\|CDD\|180279	PRK05834, PRK05834, hypothetical protein; Provisional.	3.04167e-109
NZ_CP048599.1\|WP_001264156.1\|2019_2370_-\|50S-ribosomal-protein-L20	gnl\|CDD\|179959	PRK05185, rplT, 50S ribosomal protein L20; Provisional.	2.31779e-61

>NZ_CP048599.1|WP_077657577.1|5462_7895_+|pyruvate,-water-dikinase
MRYIKFFKELNNKNVNLVGGKNASIGEMFQELVPIGIKVPDGFAITSEAYWYLLEQGGAKQKIIELLENVDATEIDVLKIRSKQIRELIFGTPFPSDLRDEIFQAYEILSRQYDMKEADVAVRSSATAEDLPDASFAGQQDTYLNIKGKTELIHYIKSCLASLFTDRAISYRASRGFDHLKVALSVGVQKMVRADKGSAGVMFSIDTETGFKDAVFITSAWGLGENVVGGTINPDEFYVFKPTLEQNKRPIIKRQLGNKTQKMVYAPRGSEHPTRNIKTTKKEWQSFSLSDEDVLILAKYAIEIEKHYSKEAKQYRPMDIEWAKDGESGEIFIVQARPETVQSQKSKEENQVFEKFKFKNPNEKKEIILQGRAIGSKIGSGKVRIINDLEHMNSFKEGEILVTDNTDPDWEPCMKKASAVITNRGGRTCHAAIVAREIGVPAIVGVSGATDSLYTGMEITVSCAEGEEGYVYAGIYEHEIERVELSNMQETQTKIYINIGNPEKAFSFSQLPNHGVGLARMEMIILNQIKAHPLALVDLHHKKSVKEKNEIENLMAGYANPKDFFVKKIAEGIGMISAAFYPKPVIVRTSDFKSNEYMRMLGGSSYEPNEENPMLGYRGASRYYSESYNEAFSWECEALALVREEMGLTNMKVMIPFLRTIEEGKKVLEILRKNNLESGKNGLEIYIMCELPVNVILADDFLSLFDGFSIGSNDLTQLTLGVDRDSELVSHVFDERNEAMLKMFKKAIEACKRHNKYCGICGQAPSDYPEVTEFLVKEGITSISLNPDSVIPTWNAVAKLEKELKEHGLT
>NZ_CP048599.1|WP_163562670.1|3247_5086_-|threonine--tRNA-ligase
MSAELIAVYKDEQIIDLESAKVLGLSDGIKALKGSDPIYFDDSPLALEVIRHSCAHLLAQSLKALYPDAKFFVGPVVEEGFYYDFKTSSKISEEDLPKIEAKMKEFAKLKLAITKETLTREQALERFKGDELKHAVMSKISGDIFGVYQQGEFEDLCKGPHLPNTRFLNHFKLTKLAGAYLGGDENNEMLIRIYGIAFATKEGLKDYLFQIEEAKKRDHRKLGVELGLFSFDDEIGAGLPIWLPKGARLRKRIEDLLSKALLLRGYEPVKGPEILKSDVWKISGHYDNYKENMYFTTIDEQEYGIKPMNCVGHIKVYQSALHSYRDLPLRFYEYGVVHRHEKSGVLHGLLRVREFTQDDAHIFCSFEQIQSEVSAILDFTHKIMRAFDFSYEMELSTRPAKSIGDDEVWEKATNALKEALKEHRIDYKIDEGGGAFYGPKIDIKITDALKRKWQCGTIQVDMNLPERFKLAFTNERNHAEQPVMIHRAILGSFERFIAILSEHFGGNFPFFVAPTQIALIPINEEHHVFALKLKEELKKRDIFVEVLDKNDSLNKKVRLAEKQKIPMILVLGNEEMETEILSIRDREKQAQYKMPLKEFLNMVESKMQEVSF
>NZ_CP048599.1|WP_001941583.1|2639_3251_-|translation-initiation-factor-IF-3
MSRSEVLLNGDINFKEVRCVGDDGEVYGIISSKEALKIAQNLGLDLVLISASAKPPVCKVMDYNKFRYQNEKKIKEAKKKQKQIEIKEIKLSTQIAQNDINYKVKHAREFIEANKHVKFKVVLKGRESQNSKAGLDVLLRVQTMMEDLANPEKEPKTEGRFVSWMFVPKAKETPKNEKKTKENNPPFNRINLMKGENHAKNED
>NZ_CP048599.1|WP_001125542.1|2464_2659_-|50S-ribosomal-protein-L35
MPKMKTNRGASKRFKVKKNLIKRGSAFKSHILTKKSPKRKANLNAPKHVHHTNAHSVMSLLCRA
>NZ_CP048599.1|WP_001264156.1|2019_2370_-|50S-ribosomal-protein-L20
MRVKTGVVRRRRHKKVLKLARGFYSGRRKHFRKAKEQLERSMYYAFRDRKQKKREFRSLWVVRINAACRMHDTSYSRFMHALKVANIELDRKVLADMAMNDMQAFKSVLESVKEHL
>NZ_CP048599.1|WP_000750214.1|959_1820_-|outer-membrane-protein
MKKSVIVGAISLAMTSLLSAETPKQEKAIKTSPTKKGERNAAFIGIDYQLGMLSTTAQNCSNGNCNGNQSGAYGSNTPNMPTASNPTGGLTHGALGTRGYKGLSNQQYAINGFGFVVGYKHFFKKSPQFGMRYYGFFDFASSYYKYYTYNDYGMRDARKGSQSFMFGYGAGTDVLFNPAIFNRENLHFGFFVGVAIGGTSWGPTNYYFKDLAEEYRGSFHPSNFQVLVNGGIRLGTKHQGFEIGLKIQTIRNNYYTASADNVPEGTTYRFTFHRPYAFYWRYIVSF
>NZ_CP048599.1|WP_078243657.1|175_607_-|DUF1104-domain-containing-protein
MKKLAFSLLFTGTFFGLFLNASDFKSMNDKQLLEQAGKVAPSEVPEFRAEINKRLAVMKEEDRKNYKADFKKAMDKNLASLSQEDRNKRKKEILEAIANKKKTMTMKEYREEGLDLHDCACEGPFHDHEKKGKKGKKPSHHKH
>NZ_CP048599.1|WP_163562671.1|9339_10266_-|radical-SAM-protein
MAKENPPVVFGPVLSRRFGKSLGVDLSPSKKQCNYNCIYCELGKAKPIERMEEVIKVETLINAIQNALNNLATPIDVLTITANGEPTLYPHLLELIQSIKPFLKGVKTLILSNGSLFYEPKVQQALKEFDIVKFSLDAIDLKAFERVDKPYSKDINKILEGILSFSQIYQGQLVAEVLLIKGVNDSANNLKRIADFLKKINTARVDLSTIDRPSSFKAPKLSEDELLKCSLFFEGLCVSLPKRSTAHAKKLISCGIDELFALISRRPLSAEEAPLILDPNAFRHLETLLNHKQITIKKVGSLEFYCAF
>NZ_CP048599.1|WP_163562672.1|10258_12469_-|type-I-DNA-topoisomerase
MKHLIIVESPAKAKTIKNFLDKNYEVVASKGHVRDLSKFALGIKIDETGFTPNYVVDKDHKELVKQIIELSKKASITYIATDEDREGEAIGYHVACLIGGKLESYPRIVFHEITQNAILNALKTPRQIDMSKVNAQQARRFLDRIVGFKLSSLISSKITKGLSAGRVQSAALKLVIDKEREIKAFKPLTYFTLDALFEPNLEAQLISYKGNKLKAQELIDGKKAQEIKNELEKESYIISSIVKKSKKSPTPPPFMTSTLQQSASSLLGFSPTKTMSIAQKLYEGVATPQGVMGVITYMRTDSLNIAKEALEEARAKILKDYGKDYLPPKAKVYSSKNKNAQEAHEAIRPTSIILEPNALKDYLKPEELKLYTLIYKRFLASQMQDALFESQSVVVACEKGEFKASGRKLLFDGYYKILGNDDKDKLLPNLKENDPIKLEKLESNAHVTEPPVRYSEASLIKVLESLGIGRPSTYAPTISLLQNRDYIKVEKKQISALESAFKVMEILEKHFEEIVDSKFSASLEEELDNIAQNKADYQQVLKDFYYPFMDKIEAGKKNIISQKVHEKTGQSCPKCGGELVKKNSRYGEFIACNNYPKCKYVKQTENANNEATQELCEKCGGEMVQKFSRNGAFLACNNYPECKNTKSLKNTPNAKEIIEGVKCPECGGDIALKRSRKGSFYGCNNYPKCNFLSNHKPINKRCEKCHYLMSERMYRKKKAHECIKCKERVFLEEDNG
>NZ_CP048599.1|WP_000010011.1|12634_14179_+|flagellin-B
MSFRINTNIAALTSHAVGVQNNRDLSSSLEKLSSGLRINKAADDSSGMAIADSLRSQSANLGQAIRNANDAIGMVQTADKAMDEQIKILDTIKTKAVQAAQDGQTLESRRALQSDIQRLLEELDNIANTTSFNGQQMLSGSFSNKEFQIGAYSNTTVKASIGSTSSDKIGHVRMETSSFSGAGMLASAAAQNLTEVGLNFKQVNGVNDYKIETVRISTSAGTGIGALSEIINRFSNTLGVRASYNVMATGGTPVQSGTVRELTINGVEIGTVNDVHKNDADGRLTNAINSVKDRTGVEASLDIQGRINLHSIDGRAISVHAASASGQVFGGGNFAGISGTQHAVIGRLTLTRTDARDIIVSGVNFSHVGFHSAQGVAEYTVNLRAVRGIFDANVASAAGANANGAQAETNSQGIGAGVTSLKGAMIVMDMADSARTQLDKIRSDMGSVQMELVTTINNISVTQVNVKAAESQIRDVDFAEESANFSKYNILAQSGSFAMAQANAVQQNVLRLLQ
>NZ_CP048599.1|WP_163562673.1|14239_16123_+|motility-associated-factor-glycosyltransferase-family-protein
MDIYQKNLQALFKKDPLLFAKLKAIKENKKYEVFLGNDSANFNLLDKETNTPLFEKSPLDSSLELYKNSEIYMLYPYLYYFGLGNGVFYRLLLGNGNLKRLVVIEPEIEIIFIVLNLLDFSTEILENRLILLHASFCNYNMIASLFDMDKKSRLYARMYDLKLFNAYYERYSHQMIEINQHFTRALEHGAISVGNDAKDALIGIKQHAANLPEVIKSPSLVDFVNALKNRDTAIIVSTGPSLNKQLPLLKEIAPYATLFCIDASFPILAKAGIKPDIVLSLERVDLTAKFYEETPLDFQEGVIFALTSIVHKRLIQAIKKGVKQFSFRPFGYTNLFDLHQYGYVGIGMSAANMAYELVVHSRFKRCVFIGQDLSFSQSGNSHASGAIYGDREIKPKKDKDKIFIEKYGGNGEVETTLVWKLFLEFFEKDIFNTPYKLEVINATEGGARIKGTKEMPFKEVCEKIDKSKPKPPINLIYPTQSEQAKNLKIAKQKCEEIIKYANEKKTQVEEAFLKVAEFLEKVEKLHEEKKLEELDFKELENLSAEIDNVKEFFDDKRFNSYFMDAIQSYIFHQELHIAEIVCKKTNNEDELRAKQLEYIYAHKYWLFSLAGGMDCVIEAIKMALKEW
>NZ_CP048599.1|WP_123946704.1|16133_16430_-|hypothetical-protein
MTINTHYTPNFTQLQTLNNINNDATIKDRNQVEQDLQQSSIQDGFSQDNAPNAPDFDRLQALNAINNDGEIKDRSQVEKSLADGENTPEIYSSLDTYA
>NZ_CP048599.1|WP_097714748.1|16450_17089_-|hypothetical-protein
MLNMNTHTRGIDSNLIHSLQSISLSMFRKGFFGLYQGSISARIGTNQFVINKRNAVFDQLNENTLLVLHDKIDYRWKEASLDSPIHASVYREFLDAKFIAYARPPYSLAYSLRHNRLLPRDYLGYRSLGEEIAIFNPKDYDSWQERADTEILRQLQESKKYFVFIKGCGIFAYHRELPKLMEVFDLIENSCKVLRLGDLMDYCYNDDPRLSV
>NZ_CP048599.1|WP_163562674.1|17299_18130_+|HrcA-family-transcriptional-regulator
MVIDEIFQIMMLRRIKVGSNLNKKESLLDAFVKTYLQILEPISSKRLKELANLKISCATIRNYFQILSKEGMLYQAHSSGARLPTFKAFENYWHKSLRFEVLKVNEKRLKSASENFGLFTLLKKPSLERLERVIECEKRFLILDFLAFSCALSYSVKMEKFLLELVGKSVKEVRLIAASVNALSLAKQLERLEYSNTQITRFNLMGLKTLLNSPLFFDILEGKVLERFKKGLHFIEPDCMLVIRPIEFQNERMQLLCVGKLECDYEGFFQTISKEE
>NZ_CP048599.1|WP_163562675.1|18129_18702_+|nucleotide-exchange-factor-GrpE
MKDEHNQEHDLSQKEPEFYQKACTCKEQQGEEKQEAGEKEGEIKEDFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAHKSAAEENKESALTKGLELTMEKLHEVLARHGIEGIECLEEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPAMVSIAKND
>NZ_CP048599.1|WP_163562676.1|18732_20595_+|molecular-chaperone-DnaK
MGKVIGIDLGTTNSAMAVYEGNEAKIIANKEGKNTTPSIVAFTDKGEILVGESAKRQAVTNPEKTIYSIKRIMGLMFNEDKAKEAEKRLPYKIVDRNGACAIEISGKIYTPQEISAKILMKLKEDAESYLGESVTEAVITVPAYFNDSQRKATKEAGTIAGLNVLRIINEPTSAALAYGLDKKESEKIMVYDLGGGTFDVTVLETGDNVVEVLATGGDAFLGGDDFDNRVIDFLAAEFKSETGIEIKNDVMALQRLKEAAENAKKELSSAMETEINLPFITADATGPKHLVKKLTRAKFESLTEDLMEETISKIESVIKDAGLTKNEISEVVMVGGSTRIPKVQERVKAFINKDLNKSVNPDEVVAVGASIQGGVLKGDVKDVLLLDVTPLSLGIETLGGVMTKVIDRGTTIPAKKSQVFSTAEDNQPAVSIMVLQGERDLARDNKSLGKFDLQGIAPAPRGVPQIEVTFDIDANGILTVSAQDKNTGKSQEIKISGSSGLSDSEIEKMVKDAELHKEEDARKKEVIEARNHADSLAHQTQKSLDEHKTNLNENDANEIQNAINALKDCIKNDNATKAELEDKTKALVQAAQKLGEAMANKNNAEQPKKKDDDVIDAEVE
>NZ_CP048599.1|WP_163562677.1|21490_22408_+|cysteine-synthase-family-protein
MIITTMQDAIGRTPVFKFTNKDYPIPLNSAIYAKLEHLNPGGSVKDRLGQYLIEEGFKTHKITSKTTIIEPTAGNTGIALALVALKHHLKTIFVVPEKFSTEKQQIMRALGALVINTPTSEGISGAIKKSKELAESIPDSYLPLQFENPDNPAAYYHTLAPEIVQELGTNFTSFVAGIGSGGTFAGTAKYLKERIPNIRLIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFANLDIDGFETISDEEGFSYTRKLAKKNGLLVGSSSGAAFVAALKEVQRLPEGSQVLTIFPDVADRYLSKGIYS

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Crispr_ID: NZ_CP048599_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048599_2

469361-469519

Orphan

I-B

Consensus_repeat	Method
GCTATTAAAATTATAAGTGCCTTGATTGAAGTTGCTGTTATCAAAGCT	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP048599_2

>merge|NZ_CP048599|2|469361-469519|PILER-CR
GGTATTAAAATTATAAGTGCCTTGATTGAAGGTGTTGTTATTAAAGCTAGCGTTATTATTAAAATTATAAGTGCCTTGATTGAAATTGCTGTTTTCAAAAGTGGATTGGGCGCTATTAAAATTATAAGTCCCTTGATTGAAGTTACTATTATCAAAGCT

>NZ_CP048599|2|1|469361-469519|PILER-CR
GGTATTAAAATTATAAGTGCCTTGATTGAAGGTGTTGTTATTAAAGCT	AGCGTTAT
TATTAAAATTATAAGTGCCTTGATTGAAATTGCTGTTTTCAAAAGTGG	ATTGGGCGCTAT
TAAAATTATAAGTCCCTTGATTGAAGTTACTATTATCAAAGCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048599.1\|WP_163562896.1\|475615_476047_+\|Sua5/YciO/YrdC/YwlC-family-protein	unknown	unknown	gnl\|CDD\|376519
NZ_CP048599.1\|WP_163562894.1\|470418_471417_-\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|273675
NZ_CP048599.1\|WP_163562898.1\|481401_482997_-\|Hop-family-adhesin-AlpB	unknown	unknown	gnl\|CDD\|280099
NZ_CP048599.1\|WP_163562900.1\|485419_487450_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NZ_CP048599.1\|WP_163562895.1\|472353_475611_+\|carbamoyl-phosphate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|235393
NZ_CP048599.1\|WP_001861281.1\|452529_452844_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048599.1\|WP_163562890.1\|459771_460446_+\|molybdate-ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|226629
NZ_CP048599.1\|WP_163562899.1\|483018_484575_-\|Hop-family-adhesin-AlpA	unknown	unknown	gnl\|CDD\|280099
NZ_CP048599.1\|WP_163562892.1\|461354_462746_-\|glutamate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234953
NZ_CP048599.1\|WP_000595790.1\|458222_458783_-\|outer-membrane-beta-barrel-protein	unknown	unknown	gnl\|CDD\|280099
NZ_CP048599.1\|WP_042636397.1\|471561_472254_+\|Bax-inhibitor-1/YccA-family-protein	unknown	unknown	gnl\|CDD\|198414
NZ_CP048599.1\|WP_163562902.1\|488585_489203_-\|restriction-endonuclease	unknown	unknown	unknown
NZ_CP048599.1\|WP_163562888.1\|454817_456554_-\|M3-family-oligoendopeptidase	unknown	unknown	gnl\|CDD\|274069
NZ_CP048599.1\|WP_163562889.1\|459008_459749_+\|molybdate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270257
NZ_CP048599.1\|WP_163562897.1\|478995_480540_+\|outer-membrane-beta-barrel-protein-HofG	unknown	unknown	gnl\|CDD\|334957
NZ_CP048599.1\|WP_163562901.1\|487453_488605_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|223897
NZ_CP048599.1\|WP_163562887.1\|454344_454833_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048599.1\|WP_163562891.1\|460442_461240_+\|sulfate/molybdate-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224043
NZ_CP048599.1\|WP_163562886.1\|452845_454333_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376136
NZ_CP048599.1\|WP_000431950.1\|456651_457902_-\|cation:proton-antiporter	unknown	unknown	gnl\|CDD\|223551

Protein	Function_ID	Function_description	E-value
NZ_CP048599.1\|WP_163562896.1\|475615_476047_+\|Sua5/YciO/YrdC/YwlC-family-protein	gnl\|CDD\|376519	pfam01300, Sua5_yciO_yrdC, Telomere recombination. This domain has been shown to bind preferentially to dsRNA. The domain is found in SUA5 as well as HypF and YrdC. It has also been shown to be required for telomere recombniation in yeast.	6.84421e-05
NZ_CP048599.1\|WP_163562894.1\|470418_471417_-\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|273675	TIGR01534, Glyceraldehyde-3-phosphate_dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, type I. This model represents glyceraldehyde-3-phosphate dehydrogenase (GAPDH), the enzyme responsible for the interconversion of 1,3-diphosphoglycerate and glyceraldehyde-3-phosphate, a central step in glycolysis and gluconeogenesis. Forms exist which utilize NAD (EC 1.2.1.12), NADP (EC 1.2.1.13) or either (1.2.1.59). In some species, NAD- and NADP- utilizing forms exist, generally being responsible for reactions in the anabolic and catabolic directions respectively. Two Pfam models cover the two functional domains of this protein; pfam00044 represents the N-terminal NAD(P)-binding domain and pfam02800 represents the C-terminal catalytic domain. An additional form of gap gene is found in gamma proteobacteria and is responsible for the conversion of erythrose-4-phosphate (E4P) to 4-phospho-erythronate in the biosynthesis of pyridoxine. This pathway of pyridoxine biosynthesis appears to be limited, however, to a relatively small number of bacterial species although it is prevalent among the gamma-proteobacteria. This enzyme is described by TIGR001532. These sequences generally score between trusted and noise to this GAPDH model due to the close evolutionary relationship. There exists the possiblity that some forms of GAPDH may be bifunctional and act on E4P in species which make pyridoxine and via hydroxythreonine and lack a separate E4PDH enzyme (for instance, the GAPDH from Bacillus stearothermophilus has been shown to posess a limited E4PD activity as well as a robust GAPDH activity). There are a great number of sequences in the databases which score between trusted and noise to this model, nearly all of them due to fragmentary sequences. It seems that study of this gene has been carried out in many species utilizing PCR probes which exclude the extreme ends of the consenses used to define this model. The noise level is set relative not to E4PD, but the next closest outliers, the class II GAPDH's (found in archaea, TIGR01546) and aspartate semialdehyde dehydrogenase (ASADH, TIGR01296) both of which have highest-scoring hits around -225 to the prior model. [Energy metabolism, Glycolysis/gluconeogenesis].	1.69738e-158
NZ_CP048599.1\|WP_163562898.1\|481401_482997_-\|Hop-family-adhesin-AlpB	gnl\|CDD\|280099	pfam01856, HP_OMP, Helicobacter outer membrane protein. This family seems confined to Helicobacter. It is predicted to be an outer membrane protein based on its pattern of alternating hydrophobic amino acids similar to porins.	1.29623e-53
NZ_CP048599.1\|WP_163562900.1\|485419_487450_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	9.16377e-136
NZ_CP048599.1\|WP_163562895.1\|472353_475611_+\|carbamoyl-phosphate-synthase-large-subunit	gnl\|CDD\|235393	PRK05294, carB, carbamoyl-phosphate synthase large subunit.	0
NZ_CP048599.1\|WP_163562890.1\|459771_460446_+\|molybdate-ABC-transporter-permease-subunit	gnl\|CDD\|226629	COG4149, ModC, ABC-type molybdate transport system, permease component [Inorganic ion transport and metabolism].	1.20823e-80
NZ_CP048599.1\|WP_163562899.1\|483018_484575_-\|Hop-family-adhesin-AlpA	gnl\|CDD\|280099	pfam01856, HP_OMP, Helicobacter outer membrane protein. This family seems confined to Helicobacter. It is predicted to be an outer membrane protein based on its pattern of alternating hydrophobic amino acids similar to porins.	7.47479e-54
NZ_CP048599.1\|WP_163562892.1\|461354_462746_-\|glutamate--tRNA-ligase	gnl\|CDD\|234953	PRK01406, gltX, glutamyl-tRNA synthetase; Reviewed.	0
NZ_CP048599.1\|WP_042636397.1\|471561_472254_+\|Bax-inhibitor-1/YccA-family-protein	gnl\|CDD\|198414	cd10432, BI-1-like_bacterial, Bacterial BAX inhibitor (BI)-1/YccA-like proteins. This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.	1.70822e-52
NZ_CP048599.1\|WP_000595790.1\|458222_458783_-\|outer-membrane-beta-barrel-protein	gnl\|CDD\|280099	pfam01856, HP_OMP, Helicobacter outer membrane protein. This family seems confined to Helicobacter. It is predicted to be an outer membrane protein based on its pattern of alternating hydrophobic amino acids similar to porins.	3.2207e-23
NZ_CP048599.1\|WP_163562889.1\|459008_459749_+\|molybdate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270257	cd13539, PBP2_AvModA, Substrate binding domain of ModA/WtpA from Azotobacter vinelandii and its closest homologs;the type 2 periplasmic binding protein fold. This subfamily contains domains found in ModA proteins that serve as initial receptors in the ABC transport of molybdate in eubacteria and archaea. Bacteria and archaea import molybdenum and tungsten from the environment in the form of the oxyanions molybdate (MoO(4) (2-)) and tungstate (WO(4) (2-)). After binding molybdate with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. In contrast to the structure of the two ModA homologs from Escherichia coli and Azotobacter vinelandii, where the oxygen atoms are tetrahedrally arranged around the metal center, the structure of Pyrococcus furiosus ModA/WtpA (PfModA) has shown that a binding site for molybdate and tungstate is where the central metal atom is in a hexacoordinate configuration. This octahedral geometry was rather unexpected. The ModA proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.83782e-99
NZ_CP048599.1\|WP_163562897.1\|478995_480540_+\|outer-membrane-beta-barrel-protein-HofG	gnl\|CDD\|334957	pfam02521, HP_OMP_2, Putative outer membrane protein. This family consists of putative outer membrane proteins from Helicobacter pylori (campylobacter pylori).	1.2915e-178
NZ_CP048599.1\|WP_163562901.1\|487453_488605_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|223897	COG0827, COG0827, Adenine-specific DNA methylase [DNA replication, recombination, and repair].	1.22405e-52
NZ_CP048599.1\|WP_163562888.1\|454817_456554_-\|M3-family-oligoendopeptidase	gnl\|CDD\|274069	TIGR02290, oligoendopeptidase_F, oligoendopeptidase, pepF/M3 family. The M3 family of metallopeptidases contains several distinct clades. Oligoendopeptidase F as characterized in Lactococcus, the functionally equivalent oligoendopeptidase B of group B Streptococcus, and closely related sequences are described by TIGR00181. The present family is quite similar but forms a distinct clade, and a number of species have one member of each. A greater sequence difference separates members of TIGR02289, probable oligoendopeptidases of the M3 family that probably should not be designated PepF.	0
NZ_CP048599.1\|WP_163562891.1\|460442_461240_+\|sulfate/molybdate-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224043	COG1118, CysA, ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism].	7.5299e-105
NZ_CP048599.1\|WP_163562886.1\|452845_454333_-\|hypothetical-protein	gnl\|CDD\|376136	pfam18712, DUF5644, Family of unknown function (DUF5644). This is a domain of unknown function found at the C-terminal region of Helicobacterial proteins of unknown function.	1.15119e-54
NZ_CP048599.1\|WP_000431950.1\|456651_457902_-\|cation:proton-antiporter	gnl\|CDD\|223551	COG0475, KefB, Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism].	5.19489e-57

>NZ_CP048599.1|WP_163562892.1|461354_462746_-|glutamate--tRNA-ligase
MSLIVTRFAPSPTGYLHIGGLRTAIFNYLFARANQGKFFLRIEDTDLSRNSIEAANAIIEAFKWVGLEYDGEILYQSRRFEIYKEYIQKLLDEGKAYYCYMSKEELDALREEQKARKETPRYDNRYRDFKGTPPKGIEPVVRIKVLQNEIIVFNDGVKGEVKVNTNELDDFIIARSDGTPTYNFVVTIDDALMGITDVIRGDDHLSNTPKQIVLYKALNFKIPNFFHVPMILNEEGQKLSKRHGATNVMDYQERGYLKEALVNFLARLGWSYQDKEIFSMQELLECFDPKDLNSSPSCFSWHKLNWLNAHYLKNQSTQELLELLKPFSFSDLSHLNPAQLNRLLDALKERSQTLKELALKIDEVLIAPIEYEEKVFKKLNQALVMPLLEKFKLELNKVNFNDENALENAMHQIIEEEKIKAGNFMQPLRLALLGKGGGIGLKEALFILGKTESIKRIEKFLKN
>NZ_CP048599.1|WP_163562891.1|460442_461240_+|sulfate/molybdate-ABC-transporter-ATP-binding-protein
MIKARFKKRLLGSRGAFDLDIDLEIKKAEVVALLGESGAGKSTILRILAGLEAVSSGYIEANHSVWLDTQKKIFLKPQQRKIGFVFQDYALFPHLNVYQNIAFAHPKDTNKIHEVLRLMRLENLSQQKILQLSGGQAQRVALARALIAAKNLLLLDEPLNALDNALKNEVQQGLLDFIKRENLSVLLVSHDPNEITKLARTFLFLNNGVINPNQENRLFSNRLLVKPLFEDENYCHYEVIPQTISLPKDCLNPTFKLDFNQNKKF
>NZ_CP048599.1|WP_163562890.1|459771_460446_+|molybdate-ABC-transporter-permease-subunit
MDHEFLITMRLSFSLALITTLILLPIGIFLGYFLSLKRNLLTSLTETLVYMPLVLPPSVLGFYLLLIFSPSSFLGAFLQDALNMKLVFSFQGLILGSVIFSLPFMVSPIKSALISLPASLKEASYSLGKGEYYTLFFVLLPNIKPSLLMAIITTFTHTIGEFGVVMMLGGDILGETRVASIAIFNEAEALNYSKAHQYALTLTLISFSLLFVTLFLNKKQSSFL
>NZ_CP048599.1|WP_163562889.1|459008_459749_+|molybdate-ABC-transporter-substrate-binding-protein
MKNTFKAFVFLIVFFSSALLAQDLKIAAAANLTHALKALVKEFQKEHPKDAVKISFNSSGKLYAQIAQNAPFDLFISADIARPKKLYDEKITPFKEEVYAKGVLVLWSENLKMDSLEILKDPKIKYIAMANPKLAPYGKASMEVLDHLKLTPSLKSKIIYGASISQAHQFVATKNAQIGFGALSLMDKKDKNLSYFIIDKALYNPIEQALIITKNGANNPLAKVFKDFLFSPKARAIFKEYGYIVD
>NZ_CP048599.1|WP_000595790.1|458222_458783_-|outer-membrane-beta-barrel-protein
MIKRIACILSLSTSLALAGEVNGFFMGAGYQQGRYGPYNSNYSDWRHGNDLYGLNFKLGFVGFANKWFGARVYGFLDWFNTSGTEHTKTNLLTYGGGGDLIVNLIPLDKFALGLIGGVQLAGNTWMFPYDVNQTRFQFLWNLGGRMRVGDRSAFEAGVKFPMVNQGSKDVGLIRYYSWYVDYVFTF
>NZ_CP048599.1|WP_000431950.1|456651_457902_-|cation:proton-antiporter
MENSTLYIVIAGLWLAVGFGIFLKKLDMPVIIGYICTGTVLAAFFKINDFNLLSDIGEFGIVFLMFMIGIEFNFDKLKSIKQEVLVFGLLQVILCALIAFLVGYFVLGLSPIFSLVLGMGLSLSSTAIVLKFFEDSKQLSTPMGKSAVGILIFQDIAAIPMLLILTILGSKDSNVNLLILKTLISAGIILVLLLLPGKKGANLILEQAKDTRLPEIFIGTILVIVCSAAGLSHFFGFSMSLGAFIVGMAISKSRYKINVQEEFAQLKNLFLALFFITIGMQINVSFFMEKFFVVIFLLILVMGFKTAIIYALLRFFRDAKTAIKTALSLAQIGEFSFVIFLNSGSHQLFNLQEKKGILGFLHQKNILNIAQNDIHQLLILMVVFSMLATPFILKYLESIAQFILHQKSQENEPAKK
>NZ_CP048599.1|WP_163562888.1|454817_456554_-|M3-family-oligoendopeptidase
MKEQEWDLSALFENKESAEEFLKTLQTEAQEFENAYQNNLKDLDAAKFANTLKHYENLSEKISRVMAYAQLLFAKNTKETKFYSQCEMACANIQQHLLFFEIEFKNLDAKKQLAFIKKCKDHAFYLNNLIEKKKHTLNLDEEKIALALSPVGVGAFSRLFDEHFSSLKIPFEEQNLSEEEILALLHNPKRKIRKKSQKAFSKALEKSRPLLTYILNMVRKDLLIETKLRKYDKKESFRHIDNQISQESVDSMIEIVNANFSLVHRYYHQKAQILGHKLKDYDRYAPLNDESITMTYSQALEEVLKTLKAFSPEFHKIASKAIKEGWVDSHPKDFKQGGAFSHGAVPSAHPYVLLNYTGNRRDAFTIAHEFGHMIHQELSKKQGVLNMDTPLTTAETASVFSEMLFFEHLKKGLKSDELLFMLAGKLEDIFSTLFRQVVMTNFERRIHEMDEELDTKDFDQIWFEENQRMFEKSVKLTKNYHLWWSYIPHFIHSPFYCYAYSYGQLLTLALYGLYKKSDAKEFVKIYTEFLSLGGSKSPKELVSMFGFDIDSKEFWEIGMQEVRHLLEEFERLLACKEN
>NZ_CP048599.1|WP_163562887.1|454344_454833_-|hypothetical-protein
MQRELRLLNNKHCVEYLQFLSKNHLSFNLLCERDAIDFSPKLPKEIHEKFGALVLFVLAGYTLESLMIDTQSVQFEAGFGPNNIGSVVQVKLPGIIQILIKEKNENAVLFNRCDSLELFHKEEPLFQEPKKDERESKEWLDSKEALFSNSKNRAILENLHKS
>NZ_CP048599.1|WP_163562886.1|452845_454333_-|hypothetical-protein
MSVLKLHVKVFRFETNKDYNPAYESYFLEYQEDQYLLDLLKQLKGVSYSENIALKINQIAVFEDAKVSDLVAFFSKEWVLDPLSKRYALKDLMIDEKAVLKNYEDFFKQVPYITKGEKEELEKFIQINFINPQTNPKYLGDGFFLYVKWLMKRYPTERDRLLEMISQPESGVMNFLSVAHYLYKNDDNIDHEIYELQEILTNSKIKPWKDFSKNLLSLFQYNSNPPKTPNPPKTCALFNAYAKHLDAQALLKSAKLYLEKMGQKIIDLPFCYDGGYYGKIISTHDFLTASAYNLALAKANGVSLIFCEEDAYLNILHAKEVLDNNPEIINSVNEKLKKYQLVYEKGVEVVYLNEWVNEFLAWELKSPFDAFLGAEFSRIKRSDHFFNKIRLKAPHFLESFQNYAPLLEVNEASGLLQCAHLRYLGIDLGADFLIAHSLGLFHAFENLSLKASKVYKRDNDNTPTLFLPQIALMAMGEKNTQALGLDAHYHKVTFI
>NZ_CP048599.1|WP_001861281.1|452529_452844_-|hypothetical-protein
MNAFLKLALASLMGGLWYAFNGEGSEIVAIGIFVLILFVFFIRPVSFQDPEKREEYIERLKKNHERKMILQDKQKEEQMRLYQAKKERESRQKQDLKEQMKKYS
>NZ_CP048599.1|WP_163562894.1|470418_471417_-|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MKIFINGFGRIGRCVLRAVLERSDTNPKLEVIGINDPANWEILAYLLEHDSAHGLLNREARYSNYKLIIGSLEIPVFNSIKDLKGVDVILECSGKFLEPKTLENYLLLGAKKVLLSAPFIGEYDEKQYPTLVYGVNHFCYQNQAIVSNASCTTNAIAPICAILDKAFKIKEGMLTTIHSYTSDQKLIDLAHPLDKRRSRAAASNIIPTTTKAALALHKVLPNLKNKMHGHSVRVPSLDVSMIDLSLFLEKKVFKDPINDLLIEASKGVLKGVLEIDLKERVSSDFISNPSSVIIAPDLTFTLENMVKIMGWYDNEWGYSNRLVDMVQFMYHY
>NZ_CP048599.1|WP_042636397.1|471561_472254_+|Bax-inhibitor-1/YccA-family-protein
MALYDRANSRNVYAENSLLHESELVSFVKTTYKFFAGSLLLATIGALLGLMNFQAVVQYKWVFFIAEIAAFFGLMFSKSKPGLNLFMLFAFTSLSGVTLVPLLGMVIAKAGLGAIWQALGMTTIVFGLMSVYALKTKNDLANMGKMLFIALIVVVVCSLINLFLGSPMFQVVIAGASAILFSLYIAYDTQNIVKGMYDSPIDAAVSLYLDFLNVFISILQIIGIFSDRDK
>NZ_CP048599.1|WP_163562895.1|472353_475611_+|carbamoyl-phosphate-synthase-large-subunit
MPKRTDISNILLIGSGPIVIGQACEFDYSGTQSCKTLKSLGYRVILINSNPATVMTDPEFSHQTYIQPITGENIAAIIKKEKIDAILPTMGGQTALNAVMQMHQRGMLEGVELLGAKIEAIKKGEDRQAFKEAMLKIGMDLPKGRYAYNELEALEAINEIGFPAIIRASFTLAGGGSGVAYNIEEFQELAKNALDASPINEILIEESLLGWKEYEMEVIRDSKDNCIIVCCIENIDPMGVHTGDSITIAPSLTLTDKEYQRMRDASFAILREIGVDTGGSNVQFAIHPETLRMVVIEMNPRVSRSSALASKATGFPIAKVATMLAVGFSLDEIKNDITNTPASFEPSLDYIVVKIPRFAFEKFAGVSSTLGTSMKSIGEVMAIGGNFLEALQKALCSLENNWLGFESLSKDLETIKKEIRRPNPKRLLYIADAFRLGVCVDEVFELCQIDRWFLSQIQKLVKAEESINSSVLTDAKKLRGLKNLGFSDARIAAKIKENENLEVSPFEVELARSNLQIAPNFEEVDTCAAEFLSLTPYLYSTYAPNPLPPIENKQEKQEKKILIIGSGPNRIGQGIEFDYCCVHASFALKDLNIKSVMLNCNPETVSTDYDTSDTLYFEPIHFECVKSIIQRERVDGIIVHFGGQTPLKLAKDLAKMQAPIIGTPFKVIDIAEDREKFSLFLKELDIKQPENGMAKSVDEAYSIANVIGFPIIVRPSYVLGGQHMQILENIEELHHYLESVTHSLEISPKNPLLIDKFLEKAVELDVDAICDKKEVYIAGILQHIEEAGIHSGDSACFIPSTLRAEILDEIEQVSTKIALHLGVVGLLNIQFAVYENSLYLIEVNPRASRTVPFLSKALGVPLAKVATRVMVLEDLKEALKFYDKKNIVEYSKGVYKPKMPHFVALKEAVFPFNKLYGSDLILGPEMKSTGEVMGIARSLGLAFFKAQTACFNPIKNKGLIFVSIKDKDKEEACVLMKRLVELGFELCATEGTHKALEKAGVKSLKVLKISEGRPNIMDLMMNGEISMAINTSDHKSQDDAKLIRASVLKNHVSYFTTLSAIEVLLLALEESSKEDELLALQDYLK
>NZ_CP048599.1|WP_163562896.1|475615_476047_+|Sua5/YciO/YrdC/YwlC-family-protein
MALVYLAQSDTTIGLLSKDSEKLNALKGRPKNQSVLIESADFTTLKSLVRAPNAFKNLIRRSAKTTFIYPNSKAVRVIRGRHGDFLKRFKTLYSTSANLTQCAYDKEIASNLADVIVSDERGLFESASSKIFRLYKNKKVRIR
>NZ_CP048599.1|WP_163562897.1|478995_480540_+|outer-membrane-beta-barrel-protein-HofG
MKQEKYFLTSSLSLLSFLLCPVEAFDYRFSGRVENFSKIGFNNSQINTKKGIYPTESFIDIVTLAQVKVNLLPKGTENHRLSVSLGGAIAAIPYDKTKYDINQANGKIFGSIVENFIGGYHGYFFNKYLGPAYAGTSQSASYHARPYVVDTAFLRYDYKDVFGFKAGRYEANIDFMSGSNQGWEVYYQPYKTETQKLRFWWWSSFGRGLAFNSWIYEFFATVPYLKKGGNPNNSNDFINYGWHGITTTYSYKGLDAQFFYYFAPKTYNAPGFKLVYDTNRNFENVGFRSQSMIMTTFPLYYRGWYNPETNTYSLEDSTPHGSLLGRNGVTLNIRQVFWWDNFNWSIGFYNTFGNSDAFLGSHTMPRGNNTSYIGSEISITTRHAGMIGYDFWDNTAYDGLADAITNANTFTFYTSVGGIHKRFAWHVFGRVSHANKNALGQVGRANEYSVQFNASYAFTESVLLNFRITYYGARINKGYQAGYFGAPKFNNPDGDFSTNYQDRSYMMTNLTLKF
>NZ_CP048599.1|WP_163562898.1|481401_482997_-|Hop-family-adhesin-AlpB
MKQNLKPFKMIKENLMTQSQKVRFLAPLSLALSLSFNPVGAEEDGGFMTFGYELGQVVQQVKNPGKIKAEELAGLLNSNTTNNTNINIAGTGGNVAGTLGNLFMNQLGNLIDLYPTLNTTNIQQCGATNSGSSGNDATTAAAATTSSACFQGNLALYKEMVSSIKTLSQDLKNNIFQGNNNTTSANLSNQLSELNTASVYLTYMNSFLNANNQAGGIFQNNTNQTYGNSVTAQQIAYVLKQASITMGPSGNGGAAGAFLDAALAQHVFNSANAGNDLSAKEFTSLVQNIVSNSQNALTLANNANISNSTGYQVSYGGNIDQTRSTQLLNNTTNTLAKVSALNNELKANPWLGNFAAGNSSQVNAFNGFITKIGYKQFFGENKNVGLRYYGFFSYNGAGVGNGPTYNQVNLLTYGVGTDVLYNVFSRSFGSRSLNAGFFGGIQLAGDTYISTLKNSPQLASRPTATKFQFLFDVGLRMNFGILKKDLKSHNQHSIEIGVQIPTIYNTYYKAGGAEVKYFRPYSVYWVYGYAF
>NZ_CP048599.1|WP_163562899.1|483018_484575_-|Hop-family-adhesin-AlpA
MIKKNRTLFLSLALCASISYAEDDGGFFTVGYQLGQVMQDVQNPGGTKRDELARELNADTTNNILNNNTGGNVAGALSNAFSQYLYSLLGAYPEKLNGNDVSANALLGGAVGSGTCAAAGTTGSSSLNTQSACTAAGYYWLPSLSDRVLSTIGSQTNYGTNTNFPNMQQQLTYLNAANVFFNAMNKALEAKNGTSGTSGTSGATGQNGQTYSQQAIAYLQGQQTILNNAANLLKQDELLLEAFNSAVAANIGNKEFNSAVFTGLVQGIIDQSQSVYNELSKNPISGSAVNSAGINSNQANAVQGRANQLSNALYNAQVTLDKINALNNQVRSMPYLPQFRAGNSRSTNILNGFYTKVGYKQFFGKKRNIGLRYYGFFSYNGASVGFRSTQNSVGLYTYGVGTDVLYNIFSRSYQNRSVDMGFFSGIQLAGETVQSTLRDDPNVKLHGKINNTHFQFLFDFGMRMNFGKLDGKSNRHNQHTVEFGVVVPTIYNTYYKSAGTTVKYFRPYSVYWSYGYSF
>NZ_CP048599.1|WP_163562900.1|485419_487450_-|ATP-dependent-helicase
MLETLQLNPEQLKAAKALKGYNLVIASAGTGKTSTIVGRILYLLDNGIKPEEILLLTFTNKASNEMIARVAKYFKLSSKIEAGTFHAVAYRYLKEHYPNLSLKQPKELRKLLESIVDTKNALTDEDKKPYTSQHLYALYSLYTNALKQEDFSAWLSHKNPEHMPYAAFYENILEEFENTKKKHNYIDYNDLLLLFKKAMLERPSPYKEVLCDEFQDTNPLQESILDAINPPSLFCVGDYDQSIYAFNGADISIISNFTQKYKNAQVFTLTKNYRSSKEILDLANQVIQRNERIYPKNLEVVKSGKFNKPTLLNYNDNIAQCQDIAKRIVMRKDFKEVAVIFRNNASADQLEAALRSHNVPSKRKGSASFFESKEVALALDICMLLFNPKDIMAAIHILSYISDIGSNTAKDIHEALMLLGNGDLKSALIQPNQEAKIYTKKKEITSMGLFEEIFALENSSRFNSVINKAFHSHPVLMHPKISLNGAKMLSDFFILYTKAPIHSPSALIKHILESAFFQTFKTRLLKERSKNKDGSYNEFKKLQAQKRFNEKMDLLSSLAKNYQNLGRFLNGTLIGSSEATQGEGVNLLSVHASKGLEFKDVYIIDLMEGRFPNHKLMNTGGGIEEERRLFYVAITRAKENLWLSYAKNELRENAKPKEHKPSVFLYEAGLLKLDSK
>NZ_CP048599.1|WP_163562901.1|487453_488605_-|class-I-SAM-dependent-methyltransferase
MENFLNNLDIKTLGQVFTPNNIVDFMLTLKHNQGSVLEPSAGDGSFLKRLKKAVGIEIDPKICPKNALCMDFFDYPLENQFDTIIGNPPYVKHKDIAPSTKEKLHYSLFDERSNLYLFFIEKAIKHLKPKGELIFITPRDFLKSTSSVKLNEWIYKEGTITHFFELGDQKIFPNAMPNCVIFRFCKGNFSRITNDGLQFVCKKGILYFLNQSYTQKLSEVFKVKVGAVSGCDKIFKNETYGNVEFVTSITKRTNVLEKMVFVNKPNDYLLQHKDSLMQRKIKKFNESNWFEWGRMHHISPKKRIYVNTKTRQKNPFFIHQCPNYDGSILALFPYNQNLDLQNLCDKLNAINWQELGFVCDGRFLFSQRSLENALLPKDFLNLG
>NZ_CP048599.1|WP_163562902.1|488585_489203_-|restriction-endonuclease
MVPTQLNEIAEFLKTNPYNLSQPLQDGRLNSSVNEEEILNTIKDYFPIQLPRAREWWDFSFEENKIFYPVNIKTTTTKTADNLNCKLGIYYALCGLVPEFNNEIAWEKYFQKLHKDLGKNTDRDYYFLIINKNDPKDIFINSLKGIQTLQPNNLPFQCKWDNNREIVQRDFDGSKNFILSALAKSVKLRANIYLTFKEVFGEFFE

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Crispr_ID: NZ_CP048599_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048599_3

1219184-1219260

Orphan

Consensus_repeat	Method
AGGTTTTTTAGCGTCTTTTTTGT	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP048599_3

>merge|NZ_CP048599|3|1219184-1219260|CRISPRCasFinder
AGGTTTTTTAGCGTCTTTTTTGTCTTTGTGAGCCACTAATTGAGAGCTTAACTCAGGTTTTTTAGCGTCTTTTTTGT

>NZ_CP048599|3|1|1219184-1219260|CRISPRCasFinder
AGGTTTTTTAGCGTCTTTTTTGT	CTTTGTGAGCCACTAATTGAGAGCTTAACTC
AGGTTTTTTAGCGTCTTTTTTGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048599.1\|WP_163563242.1\|1213927_1215133_-\|DUF874-family-protein	unknown	unknown	gnl\|CDD\|283549
NZ_CP048599.1\|WP_000861478.1\|1220687_1221341_+\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|273475
NZ_CP048599.1\|WP_163563243.1\|1215565_1216606_-\|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|273543
NZ_CP048599.1\|WP_078264898.1\|1206663_1207995_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341025
NZ_CP048599.1\|WP_163563247.1\|1222220_1223198_-\|Sel1-like-repeat-protein-HcpG	unknown	unknown	gnl\|CDD\|276807
NZ_CP048599.1\|WP_000539097.1\|1223335_1223632_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048599.1\|WP_163563239.1\|1209956_1211336_-\|HP1184-family-multidrug-efflux-MATE-transporter	unknown	unknown	gnl\|CDD\|240548
NZ_CP048599.1\|WP_163563249.1\|1224954_1226529_-\|DNA-repair-protein-RecN	unknown	unknown	gnl\|CDD\|223571
NZ_CP048599.1\|WP_000312868.1\|1208013_1208775_+\|tRNA-2-thiocytidine(32)-synthetase-TtcA	unknown	unknown	gnl\|CDD\|236737
NZ_CP048599.1\|WP_163563246.1\|1219744_1220617_-\|class-1-fructose-bisphosphatase	unknown	unknown	gnl\|CDD\|223236
NZ_CP048599.1\|WP_163563251.1\|1227583_1228312_+\|outer-membrane-protein	unknown	unknown	gnl\|CDD\|280099
NZ_CP048599.1\|WP_163563240.1\|1211504_1212680_-\|sugar-transporter	unknown	unknown	gnl\|CDD\|179591
NZ_CP048599.1\|WP_163563245.1\|1217982_1219032_+\|lipopolysaccharide-heptosyltransferase-II	unknown	unknown	gnl\|CDD\|223928
NZ_CP048599.1\|WP_001886655.1\|1219541_1219745_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048599.1\|WP_000542870.1\|1208779_1209931_-\|cation:proton-antiporter	unknown	unknown	gnl\|CDD\|223551
NZ_CP048599.1\|WP_163563248.1\|1223650_1224958_-\|fibronectin-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224212
NZ_CP048599.1\|WP_163563244.1\|1216592_1217921_-\|histidine--tRNA-ligase	unknown	unknown	gnl\|CDD\|223202
NZ_CP048599.1\|WP_163563241.1\|1212952_1213696_+\|carbonic-anhydrase	unknown	unknown	gnl\|CDD\|225875
NZ_CP048599.1\|WP_097715536.1\|1221318_1222182_+\|3'-5'-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|236281
NZ_CP048599.1\|WP_163563250.1\|1226545_1227400_-\|NAD(+)/NADH-kinase	unknown	unknown	gnl\|CDD\|223139

Protein	Function_ID	Function_description	E-value
NZ_CP048599.1\|WP_163563242.1\|1213927_1215133_-\|DUF874-family-protein	gnl\|CDD\|283549	pfam05917, DUF874, Helicobacter pylori protein of unknown function (DUF874). This family consists of several hypothetical proteins specific to Helicobacter pylori. The function of this family is unknown.	3.57761e-102
NZ_CP048599.1\|WP_000861478.1\|1220687_1221341_+\|ribulose-phosphate-3-epimerase	gnl\|CDD\|273475	TIGR01163, Ribulose-phosphate_3-epimerase, ribulose-phosphate 3-epimerase. This family consists of Ribulose-phosphate 3-epimerase, also known as pentose-5-phosphate 3-epimerase (PPE). PPE converts D-ribulose 5-phosphate into D-xylulose 5-phosphate in Calvin's reductive pentose phosphate cycle. It has been found in a wide range of bacteria, archebacteria, fungi and plants. [Energy metabolism, Pentose phosphate pathway].	8.26154e-117
NZ_CP048599.1\|WP_163563243.1\|1215565_1216606_-\|aspartate-semialdehyde-dehydrogenase	gnl\|CDD\|273543	TIGR01296, Aspartate-semialdehyde_dehydrogenase, aspartate-semialdehyde dehydrogenase (peptidoglycan organisms). Two closely related families of aspartate-semialdehyde dehydrogenase are found. They differ by a deep split in phylogenetic and percent identity trees and in gap patterns. This model represents a branch more closely related to the USG-1 protein than to the other aspartate-semialdehyde dehydrogenases represented in model TIGR00978. [Amino acid biosynthesis, Aspartate family].	0
NZ_CP048599.1\|WP_078264898.1\|1206663_1207995_+\|MFS-transporter	gnl\|CDD\|341025	cd17472, MFS_YajR_like, Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.20637e-124
NZ_CP048599.1\|WP_163563247.1\|1222220_1223198_-\|Sel1-like-repeat-protein-HcpG	gnl\|CDD\|276807	sd00010, SLR, Sel1-like repeat. Sel1-like repeats (SLRs) share similar alpha-helical conformations with Tetratricopeptide repeats (TPRs), but with different consensus sequence lengths and superhelical topologies. SLRs contain 36 to 44 amino acids and are present in bacteria and eukaryotes but not in archaea. SLR proteins are involved in a variety of functions, and many serve as adaptor proteins for the assembly of macromolecular complexes. The SLR family was named after the Caenorhabditis elegans Sel1 protein which is predicted to fold into 11 SLRs, a transmembrane domain, and an N-terminal signal sequence. The human Sel1L protein contains an additional fibronectin type-II domain and an N-terminal PEST sequence. Its downregulation is associated with the development of breast and pancreatic carcinomas.	7.67621e-37
NZ_CP048599.1\|WP_163563239.1\|1209956_1211336_-\|HP1184-family-multidrug-efflux-MATE-transporter	gnl\|CDD\|240548	cd13143, MATE_MepA_like, Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.	2.23633e-102
NZ_CP048599.1\|WP_163563249.1\|1224954_1226529_-\|DNA-repair-protein-RecN	gnl\|CDD\|223571	COG0497, RecN, ATPase involved in DNA repair [DNA replication, recombination, and repair].	2.94165e-128
NZ_CP048599.1\|WP_000312868.1\|1208013_1208775_+\|tRNA-2-thiocytidine(32)-synthetase-TtcA	gnl\|CDD\|236737	PRK10696, PRK10696, tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional.	8.58341e-69
NZ_CP048599.1\|WP_163563246.1\|1219744_1220617_-\|class-1-fructose-bisphosphatase	gnl\|CDD\|223236	COG0158, Fbp, Fructose-1,6-bisphosphatase [Carbohydrate transport and metabolism].	6.54369e-112
NZ_CP048599.1\|WP_163563251.1\|1227583_1228312_+\|outer-membrane-protein	gnl\|CDD\|280099	pfam01856, HP_OMP, Helicobacter outer membrane protein. This family seems confined to Helicobacter. It is predicted to be an outer membrane protein based on its pattern of alternating hydrophobic amino acids similar to porins.	9.33466e-47
NZ_CP048599.1\|WP_163563240.1\|1211504_1212680_-\|sugar-transporter	gnl\|CDD\|179591	PRK03545, PRK03545, putative arabinose transporter; Provisional.	0
NZ_CP048599.1\|WP_163563245.1\|1217982_1219032_+\|lipopolysaccharide-heptosyltransferase-II	gnl\|CDD\|223928	COG0859, RfaF, ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane].	7.86549e-89
NZ_CP048599.1\|WP_000542870.1\|1208779_1209931_-\|cation:proton-antiporter	gnl\|CDD\|223551	COG0475, KefB, Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism].	1.27918e-36
NZ_CP048599.1\|WP_163563248.1\|1223650_1224958_-\|fibronectin-binding-domain-containing-protein	gnl\|CDD\|224212	COG1293, COG1293, Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription].	1.2e-42
NZ_CP048599.1\|WP_163563244.1\|1216592_1217921_-\|histidine--tRNA-ligase	gnl\|CDD\|223202	COG0124, HisS, Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis].	1.14386e-162
NZ_CP048599.1\|WP_163563241.1\|1212952_1213696_+\|carbonic-anhydrase	gnl\|CDD\|225875	COG3338, Cah, Carbonic anhydrase [Inorganic ion transport and metabolism].	2.43711e-124
NZ_CP048599.1\|WP_097715536.1\|1221318_1222182_+\|3'-5'-exonuclease	gnl\|CDD\|236281	PRK08517, PRK08517, 3'-5' exonuclease.	7.99761e-139
NZ_CP048599.1\|WP_163563250.1\|1226545_1227400_-\|NAD(+)/NADH-kinase	gnl\|CDD\|223139	COG0061, nadF, NAD kinase [Coenzyme metabolism].	2.21046e-77

>NZ_CP048599.1|WP_163563245.1|1217982_1219032_+|lipopolysaccharide-heptosyltransferase-II
MSVNAPKRMRILLRLPNWLGDGVMASSLFYTLKHHYPNAYFVLVGPTITCELFKKDEKIEAVFIDDTKKSFFRLLATYKLAQKIGRCDIAIALNSHFYSAFLLYATKTPVRIGFAQFFRSLFLSHAIMAAPKEYHQVEKYCFLFSQFLEKELDQKSVLPLKLAFNLPTHTPNTPKKIGFNPSASYGSAKRWPASYYAEVAAALLEKGHEIYFFGAKEDTIVSEEILKSVKSLLKNPLLSHNAYNLCGKTSIEELIQRIAILDLFITNDSGPMHVAASTQTPLIALFGPTDEKETRPYKAQKTIVLNHHLSCAPCKKRVCPLKNEKNHLCMQSITPLEVLQAAHILLEEP
>NZ_CP048599.1|WP_163563244.1|1216592_1217921_-|histidine--tRNA-ligase
MITPKVLSGFKDRLPKDAIQKAQLLAKVSVVFQSFGFVPIETPHLEYAQTLLPDASSDIQKEIYRFKDHGDRDVALRFDLTVPLARFVSLHHQTLGMPFKRYAIGNVFRGERAQKGRYREFTQCDFDFIGSESLVCDAEIIQVIIASLKALDLEDFCVSINHRKILNGICEYFGISQVNEVLRIVDKLEKIGLNGVEEELKKECDLNPDTIKELLEMVQIQQNDLSHAEFFEKIAYLKDYNENLKKGIQDLERLYQLLGDLQISQNLYKIDFSIARGLGYYTGIVYETTLNDMKSLGSVCSGGRYDHLTKNFSKENLQGVGASIGIDRLIVALSEMQLLDERSTQAKVLIACMHEEYFSYANRLAESLRQSGIFSEVYPEAQKIKKPFSYANHRGHEFVAVIGEEEFKSETLSLKNMHSGMQLNCLSFLKALEIIGENDEDL
>NZ_CP048599.1|WP_163563243.1|1215565_1216606_-|aspartate-semialdehyde-dehydrogenase
MKTYNVAIVGASGAVGQELIKGLENSSFPIKKFVPLASARSAGKKIKAFNKDYEILETTHEVFEKERIDIAFFSAGGSVSEEFTTSTAKTALVVDNTSFFRLHKDVPLVVPEINAKEIFNAPLNIIANPNCSTIQMTQILNPLHLHFKIKSVIVSTYQAVSGAGNKGIESLKNELKTALEYLEKDPAIDLNQVLRAGAFPYPIAFNAIAHIDTFKENGYTKEELKMVHETHKIMGVDFPISATCVRVPVLRSHSESLSIAFEKEFDLKEVYEVLKNAPSVVVCDDPSHNLYPTPLKASHTDSVFIGRLRKDLFDKKTLHGFCVADQLRVGAATNALKIALHYIKNA
>NZ_CP048599.1|WP_163563242.1|1213927_1215133_-|DUF874-family-protein
MPIIRVLVMLATMMMKLVKTAKEKKVFKNVGMSIMGIAFWEAIKDSIKKQIKKSNWICGNVKTADDYLKTHPNSWFNSAIGVATITAMLMNVCFADDQSKKEVAETQKEAENARDRANKSGIELEQEQQKTSNIETNNQIKVEQEKQKTEQEKQKTEQEQQKTEQEKQKTEQEKQKTEQEKQKTSNIETNNQIKVEQEKQKTEQEKQKTNNTQKDLVTKAEQNCQGNHNQFFIKKVGIKGGIAIEVEAECKTPKPTKTNQTPIQPKHLPNSKQPRSQRGSKAQELIAYLQKELESLPYSQKAIAKQVDFYKPSSIAYLELDPRDFNATEEWQKENLKIRSKAQAKMLEMRSLKPDSQAHLPTSQSLLFVQKIFADINKEIEAVANTEKKVEKAGYGYSKRV
>NZ_CP048599.1|WP_163563241.1|1212952_1213696_+|carbonic-anhydrase
MKKTFLIALALTASLIGAENTKWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTKPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLNPILEGIQKKQNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR
>NZ_CP048599.1|WP_163563240.1|1211504_1212680_-|sugar-transporter
MMMTKQSYQRFALMRVFVFSLSAFIFNTTEFVPVALLSDIAKSFEMESATVGLMITAYAWVVSLGSLPLMLLSAKIERKRLLLFLFALFILSHILSALAWNFWVLLISRMGIAFAHSIFWSITASLVIRVAPRNKKQQALGLLALGSSLAMILGLPLGRIIGQMLDWRSTFGVIGGVATLIALLMWKLLPPLPSKNAGTLASVPILMKRPLLMGIYLLVIMVISGHFTTYSYIEPFIIQISQFSPDITTLMLFVFGLAGVAGSFLFGRLYAKNSRKFIAFAMVLVICPQLLLFVFKNLEWVIFLQIFLWGIGITSLTIALQMRVLQLAPDATDVASAIFSGSYNVGIGSGALFGSIVIHQLGLGYIGFVGGALGLLALFWLRFITIKFKKT
>NZ_CP048599.1|WP_163563239.1|1209956_1211336_-|HP1184-family-multidrug-efflux-MATE-transporter
MLKKKIDLHKDSIRKLFFYYFIPLVFSMISLSTYSMVDGMFVGKKLGKEAIAAVNIAWPIFPGLIAYELLFGFGAASIVGYFLGQNKTHRARLVFSSVFYFVAISAFILSMALLPFSETIARFFGSNDALLSMSKRYIEIILMGSVFMVLHPLADVFVVNDKRPVLAMVAMLIGSLANIFFNYWFIFVLEVGVQGSAIATVIGHAIGVLVLMQHFWRKKGQLYFIKRFSLSSVISSAKSGVPQSTAEFSASIMILLFNTAIMHTAGERFVSMYGIVMYNAIIFFTTLFAISQGIQPIASFSYGARNLERVRAVFVFGLKAAFCIGIVFYGAYYFLDEFLIKLYLQPSEQDPLFMQETKRAMNIYYVGYVFLGMTLLCAVFFQSIQRAKSSFIITLSHTLGFIVILLPILSHFYGINGIWVTYPIAQFLAFLVALGVTYYEIKKGVFTTYKEKNPIALKT
>NZ_CP048599.1|WP_000542870.1|1208779_1209931_-|cation:proton-antiporter
MHAEFFTFALIMLLIVMAPYMSRISRLPITVVEILFGSVGAYVGFIEPTKGFEIMSEIGFLFLMFLCGLEVEIYLFKKLGVSLLKRIFAYLLILYTLSFILTFSLNLEPIFMVIFPIISLGMIMTLVKDYRKEILWLDLVLKVGVIGELLSIFGLVVVDGVYSHGLGMDLIKDLGILIVFLILIIVAFQIFKTLFWWFPHLKLFVMPKSSQFNQDVRFSLMLFFSLVAIVVWLKIEMVLGAFLAGLVVSTFFPHKSELIHKLNDVGFGFFVPLFFIHVGSTLDLKLVFLNPHLILQGILIVIAMLSLHLITSTLLWRKYFKEAKHLFSFALGASMPLTFLVTTAAVGLKAQAISQNTYYALLMAAIFEGVLFTIAIKMLNKKA
>NZ_CP048599.1|WP_000312868.1|1208013_1208775_+|tRNA-2-thiocytidine(32)-synthetase-TtcA
MAYEISKKVLHIVGKTNATYKLIEEGDKILLGLSGGKDSIMLACILARMQKHAPFKFDFKAVTVHYGLGENLKWLSDLCEEQGIEHEIIYTQIAATINEKRREKSSFCSFCSRLRRGTLYSKALEEGYNKVAIAHHLDDAVESFFMNFTYNGSLRSMPPIYRAENGLLVIRPLIKVREASSIHFVTSQNIPVAPDCNCPAKQPTSDKPPIARLATKNFLKEMQNLHPHFFDSLENAFNNVQANSFSDAKYLDA
>NZ_CP048599.1|WP_078264898.1|1206663_1207995_+|MFS-transporter
MFKKIFPLALVSSLRFLGLFIVLPVISLYADSFHSSSPLLVGLAVGGAYLTQIIFQTPMGILSDKIGRKVVVMVCLLLFLAGSLVCFIANDIVWLVIGRFIQGMGALGGVVSAMVADEVKEEERTKAMAIMGAFIFISFTISMAIGPGVVAFFGGAKWLFLLTAILTLLSLLMLLKVKDAPKISYQIKNIKAYQPNSKALYLLYLSSFFEKAFMTLIFVLIPLALVNEFHKDESFLILVYVPGALLGVLSMGIASVMAEKYNKPKGVMLSGVLLFIMSYLCLFLADSSFLGKYLWLFILGVAFFFIGFATLEPIMQSLASKFAKANEKGKVLGQFTTFGYLGSFVGGVSGGLSYHHLGVSNTSLIIVALGLIWGLSLFLLHNPSKQKNVYFPLDAYNEEQFETLGDKIIEWYVNISEEIIIVKYNSDHISEEEIIHLARNFRK
>NZ_CP048599.1|WP_001886655.1|1219541_1219745_-|hypothetical-protein
MQNSAKKLEYEERFNAALLKLQACQEEKQVTSCLKCEKVLNCKIRNSYVDAAYESMSLGEAGGFDFN
>NZ_CP048599.1|WP_163563246.1|1219744_1220617_-|class-1-fructose-bisphosphatase
MDYKHFKCKHANIVIEIISLLEKGVKKAQEILEKPDAGSYTKLENSSGDTPIKADLALDKFLEENFLSLENVKSVFSEEKETPVTKKNGSYLIAYDPLDGSSVMEANFLVGTIIGVYEKDYKAQNLVASLYVVFGHKIELVVALEEVYRYAFYQNKFHFIETIVLENKGKIVASGGNQKDFSLGLKKALEGFFAENYRLRYSGSMVADVHHVLVKKGGVFSYPQKKLRKLFEVFPLALMVEKAKGEAFYFDKGVKKRLLEQGVESYHEKSECYLASPHEAQILEKYLKGE
>NZ_CP048599.1|WP_000861478.1|1220687_1221341_+|ribulose-phosphate-3-epimerase
MKVAPSLLSADFMHLAKEIESVSNADFLHVDVMDGHYVPNLTMGPVVLENVTQMSQVPLDVHLMVENASFFVELFAPLKPQIISIHAENEKHPHRVLQLIKNSGITPGIVLNPHTHEESVKYLLESVGLVLLMSVNPGFGGQKFLDLVLEKCLKVKELIKRYNPSCLLEVDGGVNDKNIFELQQAGVDVVVSGSYIFKSKDRKLAIEGLQNVRQPLA
>NZ_CP048599.1|WP_097715536.1|1221318_1222182_+|3'-5'-exonuclease
MSDSLLHKDIQALIARLKHQDLSLGMLEKSLSRLIHDEINLEYLKACGLNFVETSENLITLKNLKTPLKDEVFSFIDLETTGSCPIKHEILEIGAVQVKGGEIINRFETLVKVKSVPDYIAELTGITYEDTLNAPSVHEALQELRLFLGNSVFVAHNANFDYNFLGRYFVEKLHCPLLNLKLCTLDLSKRAILSMRYSLSFLKELLGFGIEVSHRAYADALASYKLFEICLLNLPSYIKTTMDLIDFSKCANTLIKRPPRSKYQETPPPFSLFERTKGLFNIIKATS
>NZ_CP048599.1|WP_163563247.1|1222220_1223198_-|Sel1-like-repeat-protein-HcpG
MLRGVKKAVFRVLCLGALCLGGLMAEQDSKELIFSGITIYTDKDFTRAKEYFEKACRLNDADGCAILREAYSKVILKGNARESIEKALEHTATAKACKSNDAEKCKDLAEFYFNANDLKNALEYYSKSCKLNNVEGCMLSATFYNDMIKGLKKDKKDLEYYSKACELNYGDGCAILGDIYRNGEGVTQNFKKAFKYYSKACELNNGEGCSKLGGDYFLGESVTQDLKKAFGYYSKACELNEALTCTLVGEFYRDGEGVTKDLKKAFEYSAKACELNDAKGCYALAAFYNEGKGVAKDEKQTTENLEKSCKLGLKEACDILKEQKQ
>NZ_CP048599.1|WP_000539097.1|1223335_1223632_-|hypothetical-protein
MGVSALGNVTYINQNAPLNSAIQQGARSDMLDLAQSFQSKLELAQETRALENMQAISDKDPKEGSKNRYPNSQRAKAFGLEEEEIELWHEEHLLDIVG
>NZ_CP048599.1|WP_163563248.1|1223650_1224958_-|fibronectin-binding-domain-containing-protein
MKFFLLKKFSEFLNTQTHFNLKRLSASSFLLEAFSKEKHAFVLDLNAPYIGLSKKPPESVLKNTLALDFCLNKFTKNAKILQANVIDNDRILEITGAKDLAYKSENFILRLEMIPKKANLMILDKEKCVIEAFRFNDRVAKNDILGALPPNIYEHQEEDLDFKGLLDILEKDFLSYQHKELEHKKNQIIKRLNIQKERLKEKLENLEDPKNLQLEAKELQTQAQLLLTYQHLIHKHESRVVLKDFEDKECAIEIDKSMPLNAFINKKFTLSKKKKQKSQFLHLEEENLKEKIAFKENQINYVKGAQEESVLEMFMPFKNSKIKRPMNGYEVLYYKDFKIGLGKNQKENIKLLQDARANDLWMHVRDIPGSHLIVFCQKNAPKDEIIMELAKMLIKMQKDAFNSYEIDYTQRKFVKIIKGANVIYSKYRTISLKDT
>NZ_CP048599.1|WP_163563249.1|1224954_1226529_-|DNA-repair-protein-RecN
MRDFNNVQITRLKVRQNAVFEKLDLEFKDGLSAISGASGVGKSVLIASLLGAFGLKESNASSIEVELIAPFLDTEEYGIFREDEHEPLVISVIKKEKTRYFLNQTSLSKNTLKALLKGLIKRLSNDRFSQNELNDILMLSLLDGYIQNKNKAFSPLLGALETKFTRLEKLEKERRSLEDKKRFQKDLEERLNFEKMKLERLDLKEDEYERLLEQKKLLSSKEKLNDKIALALDVLENTHKITHALESVGHSAEFLKSALLEASALLEKEQAKLEECERLDIEKVLEKLGMLSGIIKDYGSIAHAKERLAHVKNELHNLKEIDHHCETYHKEIERLKAECLKLCEEISGFRKEYLAGFNALLSTKAKDLLLKSPSLILEEAPMSEKGAQKLVLNLQNSQLETLSSGEYSRLRLAFMLLEMEFLKDFKGVLVLDEMDSNLSGEESLAVSKALETLSSHSQIFAISHQVHIPALAKNHILVFKENHKSLAKTLNNEERVLEIARMIGGSENIESAISFAKEKLKAQE
>NZ_CP048599.1|WP_163563250.1|1226545_1227400_-|NAD(+)/NADH-kinase
MKDSLQTIGVFVRPTHYQNPLFEELEQAKEWVLTLLEDEGFESFMVDSLDGAKDAQLIEKAYAFLCLGGDGTILGALRMTHAYNKPCFGVRIGNLGFLSAVELNGLKDFLQDLKHNRIKLEEHLALEGRIGKTSFYAINEIVIAKKKALGVLDIKACAGHTPFNTYKGDGLIIATPLGSTAYNLSAHGPIVHALSQSYILTPLCDFSLTQRPLVLGAEFCLSFCAHEDALVVIDGQATYDLKANQPLYIQKSPTTTKLLQKNSRDYFKVLKEKLLWGESPSKKR
>NZ_CP048599.1|WP_163563251.1|1227583_1228312_+|outer-membrane-protein
MKKFFSQSLLSLIISMNAVSGMDGNGVFLGAGYLQGQAQMHADINSQKQATNATIKGFDALLGYQFFFEKHFGLRLYGFFDYAHANSIRLKNPNYNSEAAQVASQILGKQEINRLTNIADPRTFEPNMLTYGGAMDVMVNVINNGIMSLGAFGGVQLAGNSWLMATSSFEGILVEQALVSKKATSFQFLFNVGARLRILKHSSIEAGVKFPMLKKNPYITAKNLDIGFRRVYSWYVNYVFTF

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP048599_3	3.1\|1219207\|31\|NZ_CP048599\|CRISPRCasFinder	1219207-1219237	31	NZ_CP048599.1	672335-672365	0	1.0
NZ_CP048599_3	3.1\|1219207\|31\|NZ_CP048599\|CRISPRCasFinder	1219207-1219237	31	NZ_CP048599.1	672389-672419	0	1.0
NZ_CP048599_1	1.1\|8442\|19\|NZ_CP048599\|CRT	8442-8460	19	NZ_CP048599.1	1214584-1214602	1	0.947
NZ_CP048599_1	1.2\|8505\|19\|NZ_CP048599\|CRT	8505-8523	19	NZ_CP048599.1	1214764-1214782	1	0.947
NZ_CP048599_1	1.1\|8442\|19\|NZ_CP048599\|CRT	8442-8460	19	NZ_CP048599.1	1214509-1214527	2	0.895
NZ_CP048599_1	1.1\|8442\|19\|NZ_CP048599\|CRT	8442-8460	19	NZ_CP048599.1	1214530-1214548	2	0.895
NZ_CP048599_1	1.1\|8442\|19\|NZ_CP048599\|CRT	8442-8460	19	NZ_CP048599.1	1214605-1214623	2	0.895
NZ_CP048599_1	1.1\|8442\|19\|NZ_CP048599\|CRT	8442-8460	19	NZ_CP048599.1	1214626-1214644	2	0.895
NZ_CP048599_1	1.1\|8442\|19\|NZ_CP048599\|CRT	8442-8460	19	NZ_CP048599.1	1214668-1214686	2	0.895
NZ_CP048599_1	1.1\|8442\|19\|NZ_CP048599\|CRT	8442-8460	19	NZ_CP048599.1	1214689-1214707	2	0.895
NZ_CP048599_1	1.3\|8568\|19\|NZ_CP048599\|CRT	8568-8586	19	NZ_CP048599.1	334310-334328	2	0.895
NZ_CP048599_1	1.3\|8568\|19\|NZ_CP048599\|CRT	8568-8586	19	NZ_CP048599.1	364061-364079	2	0.895
NZ_CP048599_1	1.3\|8568\|19\|NZ_CP048599\|CRT	8568-8586	19	NZ_CP048599.1	1134886-1134904	2	0.895

1. spacer 3.1|1219207|31|NZ_CP048599|CRISPRCasFinder matches to position: 672335-672365, mismatch: 0, identity: 1.0

ctttgtgagccactaattgagagcttaactc	CRISPR spacer
ctttgtgagccactaattgagagcttaactc	Protospacer
*******************************

2. spacer 3.1|1219207|31|NZ_CP048599|CRISPRCasFinder matches to position: 672389-672419, mismatch: 0, identity: 1.0

ctttgtgagccactaattgagagcttaactc	CRISPR spacer
ctttgtgagccactaattgagagcttaactc	Protospacer
*******************************

3. spacer 1.1|8442|19|NZ_CP048599|CRT matches to position: 1214584-1214602, mismatch: 1, identity: 0.947

gaacaagaaagacagaaga	CRISPR spacer
gaacaagaaaaacagaaga	Protospacer
**********.********

4. spacer 1.2|8505|19|NZ_CP048599|CRT matches to position: 1214764-1214782, mismatch: 1, identity: 0.947

aataagagtgggatagaac	CRISPR spacer
aacaagagtgggatagaac	Protospacer
**.****************

5. spacer 1.1|8442|19|NZ_CP048599|CRT matches to position: 1214509-1214527, mismatch: 2, identity: 0.895

gaacaagaaagacagaaga	CRISPR spacer
gaacaagaaaaacaaaaga	Protospacer
**********.***.****

6. spacer 1.1|8442|19|NZ_CP048599|CRT matches to position: 1214530-1214548, mismatch: 2, identity: 0.895

gaacaagaaagacagaaga	CRISPR spacer
gaacaagaaaaacaaaaga	Protospacer
**********.***.****

7. spacer 1.1|8442|19|NZ_CP048599|CRT matches to position: 1214605-1214623, mismatch: 2, identity: 0.895

gaacaagaaagacagaaga	CRISPR spacer
gaacaagaaaaacaaaaga	Protospacer
**********.***.****

8. spacer 1.1|8442|19|NZ_CP048599|CRT matches to position: 1214626-1214644, mismatch: 2, identity: 0.895

gaacaagaaagacagaaga	CRISPR spacer
gaacaagaaaaacaaaaga	Protospacer
**********.***.****

9. spacer 1.1|8442|19|NZ_CP048599|CRT matches to position: 1214668-1214686, mismatch: 2, identity: 0.895

gaacaagaaagacagaaga	CRISPR spacer
gaacaagaaaaacaaaaga	Protospacer
**********.***.****

10. spacer 1.1|8442|19|NZ_CP048599|CRT matches to position: 1214689-1214707, mismatch: 2, identity: 0.895

gaacaagaaagacagaaga	CRISPR spacer
gaacaagaaaaacaaaaga	Protospacer
**********.***.****

11. spacer 1.3|8568|19|NZ_CP048599|CRT matches to position: 334310-334328, mismatch: 2, identity: 0.895

gaacaagaaaaacaaaaag	CRISPR spacer
gaaaaagaaaaacaagaag	Protospacer
*** ***********.***

12. spacer 1.3|8568|19|NZ_CP048599|CRT matches to position: 364061-364079, mismatch: 2, identity: 0.895

gaacaagaaaaacaaaaag	CRISPR spacer
gaaaaagaaaatcaaaaag	Protospacer
*** ******* *******

13. spacer 1.3|8568|19|NZ_CP048599|CRT matches to position: 1134886-1134904, mismatch: 2, identity: 0.895

gaacaagaaaaacaaaaag	CRISPR spacer
gaagtagaaaaacaaaaag	Protospacer
***  **************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Identity
NZ_CP048599_1	1.1\|8442\|19\|NZ_CP048599\|CRT	8442-8460	19	MN693151	Marine virus AFVG_25M560, complete genome	20625-20643	1.0
NZ_CP048599_1	1.3\|8568\|19\|NZ_CP048599\|CRT	8568-8586	19	LT960610	Bacillus phage SBSphiC genome assembly, complete genome: monopartite	127136-127154	1.0
NZ_CP048599_1	1.3\|8568\|19\|NZ_CP048599\|CRT	8568-8586	19	NC_019487	Bacillus phage SP10, complete genome	66781-66799	1.0
NZ_CP048599_1	1.3\|8568\|19\|NZ_CP048599\|CRT	8568-8586	19	AB605730	Bacillus phage SP10 DNA, complete sequence	66781-66799	1.0

1. spacer 1.1|8442|19|NZ_CP048599|CRT matches to MN693151 (Marine virus AFVG_25M560, complete genome) position: , mismatch: 0, identity: 1.0

gaacaagaaagacagaaga	CRISPR spacer
gaacaagaaagacagaaga	Protospacer
*******************

2. spacer 1.3|8568|19|NZ_CP048599|CRT matches to LT960610 (Bacillus phage SBSphiC genome assembly, complete genome: monopartite) position: , mismatch: 0, identity: 1.0

gaacaagaaaaacaaaaag	CRISPR spacer
gaacaagaaaaacaaaaag	Protospacer
*******************

3. spacer 1.3|8568|19|NZ_CP048599|CRT matches to NC_019487 (Bacillus phage SP10, complete genome) position: , mismatch: 0, identity: 1.0

gaacaagaaaaacaaaaag	CRISPR spacer
gaacaagaaaaacaaaaag	Protospacer
*******************

4. spacer 1.3|8568|19|NZ_CP048599|CRT matches to AB605730 (Bacillus phage SP10 DNA, complete sequence) position: , mismatch: 0, identity: 1.0

gaacaagaaaaacaaaaag	CRISPR spacer
gaacaagaaaaacaaaaag	Protospacer
*******************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

833695 : 841950

Streptococcus_phage(33.33%)

tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000266312.1\|833695_833956_+	hypothetical protein	S0A2X1	Cellulophaga_phage	5.9e-11	53.0
WP_163563054.1\|833930_835277_+	McrB family protein	M1NSM1	Streptococcus_phage	9.3e-84	45.1
WP_163563055.1\|835269_836484_+	LlaJI family restriction endonuclease	Q6DMW8	Streptococcus_phage	1.4e-67	36.6
WP_163563056.1\|836559_837582_-	pseudaminic acid synthase	A0A1B1IVE2	uncultured_Mediterranean_phage	2.0e-30	34.1
WP_137296403.1\|837585_838227_-	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	3.9e-16	28.7
WP_163563057.1\|838229_839501_-	apolipoprotein N-acyltransferase	NA	NA	NA	NA
WP_001106270.1\|839724_840435_+	CvpA family protein	NA	NA	NA	NA
WP_163563058.1\|840444_841950_+\|tRNA	lysine--tRNA ligase	A0A1V0SAC0	Catovirus	1.4e-91	40.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP048599

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection