CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP048830	Leptospira interrogans serovar Copenhageni strain SK1 chromosome I, complete sequence	11 crisprs	WYL,csa3,cas3,cas5,cas7,cas8b3,cas6,cas2,cas1,DinG,cas8c,cas4,Cas9_archaeal	2	3	2	0
NZ_CP048831	Leptospira interrogans serovar Copenhageni strain SK1 chromosome II, complete sequence	0 crisprs	csa3	0	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP048830_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048830_1

442549-442641

Orphan

Consensus_repeat	Method
AACGCTCTTTATGAATCGCGTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP048830_1

>merge|NZ_CP048830|1|442549-442641|CRISPRCasFinder
AACGCTCTTTATGAATCGCGTTGGAAACTCAGCATAACGCTCTTTATGAATCGCGTTGGAAACTCAGCATAACGCTCTTTATGAATCGCGTTG

>NZ_CP048830|1|1|442549-442641|CRISPRCasFinder
AACGCTCTTTATGAATCGCGTTG	GAAACTCAGCATAACGCTCTTTATGAATCGCGTTGGAAACTCAGCAT
AACGCTCTTTATGAATCGCGTTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048830.1\|WP_000494963.1\|450324_450519_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_001199925.1\|431721_433419_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173843
NZ_CP048830.1\|WP_000219654.1\|452269_452413_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000091880.1\|438734_439577_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|212463
NZ_CP048830.1\|WP_000951509.1\|439680_440229_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NZ_CP048830.1\|WP_000390637.1\|452811_453993_+\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|180261
NZ_CP048830.1\|WP_000777993.1\|454103_454394_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_100218959.1\|430979_431165_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000187969.1\|447476_447812_+\|sulfurtransferase	unknown	unknown	gnl\|CDD\|180967
NZ_CP048830.1\|WP_002084923.1\|434014_435661_-\|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|293734
NZ_CP048830.1\|WP_001288293.1\|444790_444961_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_001228669.1\|448314_449133_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277331
NZ_CP048830.1\|WP_000433865.1\|435671_435884_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000615575.1\|443021_443471_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|311556
NZ_CP048830.1\|WP_000219100.1\|451330_451942_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP048830.1\|WP_000687983.1\|429737_430283_+\|GyrI-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|336409
NZ_CP048830.1\|WP_000792403.1\|440388_441438_+\|FecR-domain-containing-protein	unknown	unknown	gnl\|CDD\|377406
NZ_CP048830.1\|WP_000481720.1\|445077_446973_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP048830.1\|WP_000043034.1\|436050_438069_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000577315.1\|429223_429730_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP048830.1\|WP_001199925.1\|431721_433419_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173843	cd01154, AidB, Proteins involved in DNA damage response, similar to the AidB gene product. AidB is one of several genes involved in the SOS adaptive response to DNA alkylation damage, whose expression is activated by the Ada protein. Its function has not been entirely elucidated; however, it is similar in sequence and function to acyl-CoA dehydrogenases. It has been proposed that aidB directly destroys DNA alkylating agents such as nitrosoguanidines (nitrosated amides) or their reaction intermediates.	2.80083e-81
NZ_CP048830.1\|WP_000091880.1\|438734_439577_-\|hypothetical-protein	gnl\|CDD\|212463	cd01716, Hfq, bacterial Hfq-like. Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotropic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that modulate the stability or translation efficiency of RNA transcripts. Hfq binds preferentially to unstructured A/U-rich RNA sequences and is similar to the eukaryotic Sm proteins in both sequence and structure. Hfq forms a homo-hexameric ring similar to the heptameric ring of the Sm proteins.	0.00370939
NZ_CP048830.1\|WP_000951509.1\|439680_440229_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	1.51091e-24
NZ_CP048830.1\|WP_000390637.1\|452811_453993_+\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|180261	PRK05790, PRK05790, putative acyltransferase; Provisional.	0
NZ_CP048830.1\|WP_000187969.1\|447476_447812_+\|sulfurtransferase	gnl\|CDD\|180967	PRK07411, PRK07411, molybdopterin-synthase adenylyltransferase MoeB.	1.24366e-24
NZ_CP048830.1\|WP_002084923.1\|434014_435661_-\|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase	gnl\|CDD\|293734	cd16010, iPGM, 2 3 bisphosphoglycerate independent phosphoglycerate mutase iPGM. The 2,3-diphosphoglycerate- independent phosphoglycerate mutase (iPGM) catalyzes the interconversion of 3-phosphoglycerate (3PGA) and 2-phosphoglycerate (2PGA). They are the predominant PGM in plants and some other bacteria, including endospore forming Gram-positive bacteria and their close relatives. The two steps catalysis is a phosphatase reaction removing the phosphate from 2- or 3-phosphoglycerate, generating an enzyme-bound phosphoserine intermediate, followed by a phosphotransferase reaction as the phosphate is transferred from the enzyme back to the glycerate moiety. The iPGM exists as a dimer, each monomer binding 2 magnesium atoms, which are essential for enzymatic activity.	0
NZ_CP048830.1\|WP_001228669.1\|448314_449133_+\|metallophosphoesterase	gnl\|CDD\|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	6.32179e-54
NZ_CP048830.1\|WP_000615575.1\|443021_443471_-\|DoxX-family-protein	gnl\|CDD\|311556	pfam07681, DoxX, DoxX. These proteins appear to have some sequence similarity with pfam04173 but their function is unknown.	2.94537e-13
NZ_CP048830.1\|WP_000219100.1\|451330_451942_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	6.87317e-13
NZ_CP048830.1\|WP_000687983.1\|429737_430283_+\|GyrI-like-domain-containing-protein	gnl\|CDD\|336409	pfam06445, GyrI-like, GyrI-like small molecule binding domain. This family contains the small molecule binding domain of a number of different bacterial transcription activators. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding. The GyrI superfamily includes a family of secreted forms that is found only in animals and the bacterial pathogen Leptospira.	1.55392e-13
NZ_CP048830.1\|WP_000792403.1\|440388_441438_+\|FecR-domain-containing-protein	gnl\|CDD\|377406	pfam04773, FecR, FecR protein. FecR is involved in regulation of iron dicitrate transport. In the absence of citrate FecR inactivates FecI. FecR is probably a sensor that recognizes iron dicitrate in the periplasm.	1.29236e-19
NZ_CP048830.1\|WP_000481720.1\|445077_446973_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	9.62426e-147

>NZ_CP048830.1|WP_000792403.1|440388_441438_+|FecR-domain-containing-protein
MKNKTNTPEFEGYSKFLKEKGPTTQLPAFDPSWIGKQPRFIVEDKIMNVSTDNTNIFRFPKIVWLAAAAILLFTIGVWVTFYTSKPESEIVRGTTLKAAVVFVKGQVSVMRDVEMKLHRGDLLNESDIILTGTGGALDIGLTDSSVVRVKENSKLILKQLREDNGSQIRINLTSGRVLNIIEKEKKTSNFYVETPSAVAAVRGTSFEVNASENESMVFVVEGAVEVISLNPAKKIYILEKSKLVTVNKDGEIESIDISKLNSTLPEYKEMRKNLGSLDSELLLDVQNLKSAKTEEELSKAYDLSIERIIMKDGRELRGVVVSQKKGKLVVQTLKGSYILDEDAVDKIKY
>NZ_CP048830.1|WP_000951509.1|439680_440229_+|sigma-70-family-RNA-polymerase-sigma-factor
MAHTSELEKLYNHNKDDLFHYIRKSFYDENSAQDILHDSFLNFFKYYENRDIPDPTSCRMILFRIARNLIINHSKSYYQRNVSLVGEDAGSSFTSKSPSPEFSVMEKIDQLDVKNIIDSLLDTISTEYKEALLLRYQQDLKLDEISKILGMSISGVSRLIERAEKALAQEGKKIGFQPADYI
>NZ_CP048830.1|WP_000091880.1|438734_439577_-|hypothetical-protein
MSRTYQLITSSGIFVLIILFPLSLTASTIVLKNGRTLQGKIINQSRTEVQIEVNGKLQTISKAEISEINLKDPKKEESKKKEVITTQPPDHTNPTTTQLSWQDTRWAITGRSAILPGWGQWKVGQKRWAIISFLLFASAALYANNCKEKAIAEENDYKINSTAITIAAFADPNLNPITSDETVRATALITRIFTTAAATNPYFNSYDRATSQYNQAQWLLGAIYGLQLIHTFLLAKDYQKLQTLLSDPSPEGWKFSTLVVRNQMNGSTEISPNIVYTIRF
>NZ_CP048830.1|WP_000043034.1|436050_438069_+|hypothetical-protein
MSKPVLNPTFGGANQTQNFLKVKKINEVVSYYLNDRLTHSVYKAIVTQTSHKNVRSQNLFQVESKVPEAPELTTAEVAFHIKRLLEDGVVLQFAYFYVDPATSELKLKPCYVAYSDAELGDLTRIYLLLVDLSVNSILSYLENRPSLGKEMLWEDLEADFKGENIQKLKLFFNPESYFQAPNISIPLNPEYVKDMLLEITDGLVKKGRIREIPEVGYLVVKIKELQTLFELVDEFHFKKVFPKYKWALSDAFAAISQEERMHANDPSALPTTLFGKKRARAIEKALESDSEIKSKRKLIGVELILNLSDEIESTLKSSYQEQIRNRFHEMTDHLSKQAGRWDKLVLFISDEEFKTYPTELKRLLTEDRHIAYSPWETKGITIHSFMRMDTETIRSVIKSLSTAANVEAWKILGIRNLIELNEDSIHSVFKDEEFVRNYGKVLRKGYVRYFPWYFSILDFVGVAKLLQDLFFQGAKEKIRSEQSYFKSKNRDAAFKLEQSKIQEKLKEDEKIKALEQKSKLSEALNQYYFERNIPPVLKEILYEIPGYSPELIHQIVDREKFVLIQDSSGDKTESILMYPNDESFRFRAKEIHKVLTEKKKSLDFKFRNKEEDFQSEKVAKTLKYLDSWFASKPEQAHASKEGKNNSGNSNEDPYENFRKEIVKIKGKEKIST
>NZ_CP048830.1|WP_000433865.1|435671_435884_+|hypothetical-protein
MEPVDYSGSQEIQILKKLGNLLSFPKSNEKIRSCTRVCDITFNAENNRVYQFVIMKKYNECFLRFVVWIV
>NZ_CP048830.1|WP_002084923.1|434014_435661_-|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase
MKLSKKYTFRSRKVLLIILDGVGYSPKGPESGNAIAGAKLPFLNRVWNQFPTLHIQAHGKAVGMPSDDDMGNSEVGHNVLGSGRIFDQGAKLVSNSIASGDIFNGQAWKEVIGNSKKNNSTLHLLGLFSDGNVHSHIDHTKALISQAILEKVPKIRLHILLDGRDVPEKSALDYLNPFETWLNSLRKSGTDIRIASGGGRMTITMDRYEADWSMVERGWKVHVKGEGRYFSSAKEAIETFRSENPKIIDQYLPSFVISDNGKPVGKIQDGDSVVFTNFRGDRAIEISLAFTEKNFDKFDRGPLPNVLYAGIMQYDGDLKLPERFLVAPPAIDRTLGEYMASSNIPQYALSETQKYGHVTYFWNGNKSGYFDQNSEEYREILSDVIPFDQSPEMKALLITEALEKALNENKQDFYRVNYANGDMVGHTGNYLATVQAMEFLDGCVERLWKTCEKQNIVLLVTADHGNADEMFQLDKKGNVEKDSHGNPIPKTSHTLNPVPISILDPENKIRFNSKLSNPGLANVAATILDVMGYETPEGYHPSLIQNES
>NZ_CP048830.1|WP_001199925.1|431721_433419_-|acyl-CoA-dehydrogenase
MQYPFNQSTNPGLAPFDISNYKGNRGKNFYEEDRVLQTLVEKYSKGYDSTHKKAMIEHLLGYGALVGGILDELTEASHKEGKYGEIVKYDRTGNRIDAVVYSNEQKLSRKISYDYGIVNLNYHSSWKHPFTDLHRYALAYLANQNGEGGVTCPLAMTEGMIKVLEALGTSEQKEKYLPLVAGEGSQSHFMAGQYVTERVGGSNVSANRTIARKQDNGKWILTGEKWFCSNPGDLWVTTARVEDTNTIGMFLVPRIKDDGTLNGHHILRKKDIIGSRGKLTVEIVYDGVEAEALGRPAHGIANLIKYVIGISRLHVSIAASGISRRAWMEAYEYAKFRTAYGSKILEFSSLLKQLSDQRLKHTAMLTSIFRHFHTPETLKLAGEVLAPLLKYKCSATSTEITYNSILVLGGNGIVGDFSPLPRLHNDSIINETWEGTHLLLSEHVLRGFKREKVAKAFFKYVEEITDPNSVAAETTLKKSELLQNLLDHSSSQELDLNRIYIADLAFETFALAALSDASGKNSPDSQKDLSAFRDGYLDLVNSSQTFSQKENFSGNTENLKSVIHF
>NZ_CP048830.1|WP_100218959.1|430979_431165_-|hypothetical-protein
MLALKACPRTKHRPAERHNQPHKYLDLNINLSELRQILCKTSSHPTTRFIKSVVLSFQRDS
>NZ_CP048830.1|WP_000687983.1|429737_430283_+|GyrI-like-domain-containing-protein
MKIFALSILVLVVLLVAFLFYMGAFNRVLVQEEMKGPFYVLSHERIGDYRNVGLTFEALQKELPEKGIRNFKLFSIYLDNPNEVPKEKLRCEVGALFSEPLEKIPNGLSLELKIRTIPSKKYLTAEFPLRNFLSIFLGIYKVYPKLFRACEERGCDLKGRASIEIYEPLTEHKTTYLLPLD
>NZ_CP048830.1|WP_000577315.1|429223_429730_+|hypothetical-protein
MIFRFFKILIQIVYPVSFPKKMKDAIQIHLEDSYRDGSFRIFYLFDILISGFRERILSEMRSLRLLWEYDHRSVFGLIILIPWNLFLILIFASLFIGGPGWLKFFHNFPYEKNVPAESVFPFLLFLAGVLLVQDLFLLKKKRSVFKRYSYLFYINMSLVVPFFLILVL
>NZ_CP048830.1|WP_000615575.1|443021_443471_-|DoxX-family-protein
MIQNFFSTKESLSPLLLRLGLSICIFPHGAQKLLGWFGGAGYEASMDYLVNTAQFPATLSILAIMSEFFGSIAILLGFCTRLSAFGITCTLAVAGWTHKEIGFFMNWFGNQNGEGFEYHILSVSMGLSLLLFGGGSWSLDSWIYDHLDS
>NZ_CP048830.1|WP_001288293.1|444790_444961_+|hypothetical-protein
MSEETQEKKNKKINKMTVAEINAAIQTSKEKMNGSSSKYILHLNARLEELAVKGKK
>NZ_CP048830.1|WP_000481720.1|445077_446973_+|ATP-binding-cassette-domain-containing-protein
MFNGFSWHIKPGSRVCLVGPNGSGKSTLFRIAEGKFIPDEGSVAKSKNTEISVFQQIPEFNPEALVIDTALEKHKHYREYSERLKEINRKFDLVSHDSKEFTTILDEQSALEEYAFTYGVHELESKARKVLGGLGFSNVQMEMKVREFSPGYQHRLGLAITLLNPGNLLLLDEPTNHLDNTSKEWLADYLNSTGQSFVLVTHDPEFLDATCDTIAELSSSEVIEFRGTLEEYFEHKNELQEKLRAQYRKEETYLKKRMEWIERFRAKATKAKQVQSAIKKLEKRNKVEAPEESFWNSKSDYRFNFISSGKITVRIEDGAFSYSDKTPSIFSGANLEISAGDKIAVVGPNGAGKSTFLRCLLEIHKLTSGKIYYGPKTKIGYFSQNHHEELDPSKNLIQTVMSAYPDLSEQQARSLLGYFSFSDDSVYKQTSLLSGGEQSRLRLAMLVRFPANSIFLDEPTNHLDLVVRDNLLRALMEYEGSLLIISHDPEFLRSLCNRTISVDKGQIRDFNCTFEDYLKYNLQETTSSKQQIGNLVFKKEETGQTRSKRNSDKNRIKKIQKDLEQLETKIELLEKSKKNLEEVLADPDFFKNRSYQLELDNLNETKNEITRLTLEWESLQLEFEELSGTVN
>NZ_CP048830.1|WP_000187969.1|447476_447812_+|sulfurtransferase
MTPKELKSRLDLRKTAKDSFYLLDVRNPNEVDICTIEGTDLLIPVGELSNRLSEIDSWKQSGKDVIVYCRSGGRSAMACGMLKQSGFSKVHNVEGGILLYSDEVDSSIIKY
>NZ_CP048830.1|WP_001228669.1|448314_449133_+|metallophosphoesterase
MRKLKFYVILILFLVGVNCFIIERYWVRFQEYEFKSDKVTKDFDGYKIAVVSDLHYGFLNPEFWVRWVIKRVNSQNADLVVGLGDYVKKRNTDVELLKVWPILKELKAKDGAYFVNGNHDHWANDKLSLELLEKSGRSIRNKNIVIRRNISKFILAGIGDFWEDRADIDKVLSGTFSKDLRIVLSHNPDSSNTKHKEKVDLFLTGHTHGGQVRIPFFNFSPVLPVKDSNFDIGFKKNKFGEDVFISAGIGWSILPIRFFCPSEISLIVLRSP
>NZ_CP048830.1|WP_000494963.1|450324_450519_-|hypothetical-protein
MFTPNALRKFKSIVISSEKVGDLKSFRLVDGPGLLVVTEAVADYLRKWDFKTLLLQPTQEYDGV
>NZ_CP048830.1|WP_000219100.1|451330_451942_-|TetR/AcrR-family-transcriptional-regulator
MTVTRHKRRSRNSLNRENIVQVAMEILQEKGIDRLSMRKIAEKLNCSVASPYSHFTSQEEIIQVLIAKGETELTQLLRNAQKNGKNAFEQLAGIARAYWDFSLNNKELHKVMFNTVHGHMHRKAFPSLPTSYRVFLETIRNGCINQEFKLPKSEYPAIARMMWAWMYGLMVLDLTNMLKRRRGGKDDPLAEGFLYFQKILLEE
>NZ_CP048830.1|WP_000219654.1|452269_452413_+|hypothetical-protein
MTWENSISNFLLSFVGGENSVKMKFVGTTTFLQDGFQKSVRTLCWNF
>NZ_CP048830.1|WP_000390637.1|452811_453993_+|acetyl-CoA-C-acetyltransferase
MEEAVILDGIRTPFGNFGGTLKDLSAVDLGVLVSKTILERTGVSPEAIGESIFGNVIPTGKEAIYLARHIGLKTGLPLGVPALTLNRLCGSGMEAIIQAAKKIYLGDADAVLAGGVESMSNAPYVVRNARWGVRYGSAEFEDTLEQGLTDQYVGLIMGQTAENLADQYKISRQEQDEWAAISQTRAEKATLEGRLKEEIFTVTIPGKKPVILEKDEFIKGASGVDKLGSLKAVFREGGTVTAGNASGLNDGAAVTIVASSSYAKKLGKKPLAIIRGYGHAGCDPAKMGIGPALAIPAALKKAGLKLSDMSLVEVNEAFAAQYLAVQKELGLNPEITNVNGGAVAIGHPLGASGARVTITLAYELKRRKAKYGIASLCIGGGQGIALVLENPEV
>NZ_CP048830.1|WP_000777993.1|454103_454394_+|hypothetical-protein
MKLSRKILKRFLLIIFVFLIFNQEMYSECAVCYTIVYVELKEKFGKKKNFFFAVPPEIEDTNGKTSPIRLDQIHLDQIEIEQKWKKTGFLTFYKKI

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Crispr_ID: NZ_CP048830_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048830_2

1133682-1133936

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAG	CRISPRCasFinder
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGA	CRT
TCCGTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGA	PILER-CR

3 spacers

cas6,cas3,cas8b3,cas7,cas5,cas2,cas1

The CRISPR arrays of NZ_CP048830_2

>merge|NZ_CP048830|2|1133682-1133936|CRISPRCasFinder,CRT,PILER-CR
TTCTAAACCGCCTATCGGCATCAAAGTTATATTCAGAAGTTTTTCACGGGGTGACGAATGTTTTCCCCTTGTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGCCCATAACGATACATTATGGGAAGTTTGGTCCTATGTCCGTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGAAATCAAGGACGAATTCTTTTGATCAAAGGATCCTTTGTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGA

>NZ_CP048830|2|2|1133682-1133935|CRISPRCasFinder
TTCTAAACCGCCTATCGGCATCAAAGTTATATTCAG	AAGTTTTTCACGGGGTGACGAATGTTTTCCCCTT
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAG	CCCATAACGATACATTATGGGAAGTTTGGTCCTATGTCC
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAG	AAATCAAGGACGAATTCTTTTGATCAAAGGATCCTTT
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAG

>NZ_CP048830|2|1|1133682-1133936|CRT
TTCTAAACCGCCTATCGGCATCAAAGTTATATTCAGA	AGTTTTTCACGGGGTGACGAATGTTTTCCCCTT
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGC	CCATAACGATACATTATGGGAAGTTTGGTCCTATGTCC
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGA	AATCAAGGACGAATTCTTTTGATCAAAGGATCCTTT
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGA

>NZ_CP048830|2|1|1133752-1133936|PILER-CR
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGCCCA	TAACGATACATTATGGGAAGTTTGGTCCTATGTCC
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGAAAT	CAAGGACGAATTCTTTTGATCAAAGGATCCTTT
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048830.1\|WP_000098756.1\|1128445_1130332_-\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP048830.1\|WP_000511225.1\|1134584_1136210_-\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP048830.1\|WP_000451419.1\|1138577_1138790_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000683530.1\|1134300_1134585_-\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP048830.1\|WP_000110274.1\|1133977_1134184_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_001060166.1\|1143456_1144293_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381297
NZ_CP048830.1\|WP_001072139.1\|1138973_1139360_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000578385.1\|1137428_1138316_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP048830.1\|WP_000533549.1\|1125124_1125307_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000083101.1\|1122230_1123412_-\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|341170
NZ_CP048830.1\|WP_000052101.1\|1127541_1128381_-\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP048830.1\|WP_000601711.1\|1130339_1132592_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP048830.1\|WP_000026907.1\|1132588_1133221_-\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP048830.1\|WP_000061285.1\|1121082_1122234_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|372509
NZ_CP048830.1\|WP_000371344.1\|1126897_1127521_-\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP048830.1\|WP_000590867.1\|1141395_1142892_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP048830.1\|WP_001110347.1\|1139702_1140254_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_080010676.1\|1136688_1136898_-\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP048830.1\|WP_000199612.1\|1123408_1124950_-\|type-I-restriction-modification-system-subunit-M	unknown	unknown	gnl\|CDD\|211578
NZ_CP048830.1\|WP_162467460.1\|1126200_1126461_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP048830.1\|WP_000098756.1\|1128445_1130332_-\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	5.64505e-163
NZ_CP048830.1\|WP_000511225.1\|1134584_1136210_-\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP048830.1\|WP_000683530.1\|1134300_1134585_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP048830.1\|WP_001060166.1\|1143456_1144293_-\|aldo/keto-reductase	gnl\|CDD\|381297	cd19071, AKR_AKR1-5-like, AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.	7.60377e-136
NZ_CP048830.1\|WP_000578385.1\|1137428_1138316_-\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000315818
NZ_CP048830.1\|WP_000083101.1\|1122230_1123412_-\|restriction-endonuclease-subunit-S	gnl\|CDD\|341170	cd17281, RMtype1_S_HpyAXIII_TRD1-CR1_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to Helicobacter pylori 26695 S subunit (S.HpyAXIII/Prototype S.Hpy26695ORF4050P) TRD1-CR1, Neisseria meningitidis 510612 S subunit (S.Nme510612ORF1157P) TRD1-CR1 and Streptococcus mitis SVGS_061 S subunit (S2.Smi61ORF7905P) TRD1-CR1. Helicobacter pylori 26695 S subunit (S.HpyAXIII/Prototype S.Hpy26695ORF4050P) recognizes 5'... CTANNNNNNNNTGT ... 3', and the recognition sequences of Neisseria meningitidis 510612 S subunit (S.Nme510612ORF1157P) and Streptococcus mitis SVGS_061 S subunit (S2.Smi61ORF7905P) are undetermined. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. For example, Helicobacter pylori 26695 S subunit (S.HpyAXIII/Prototype S.Hpy26695ORF4050P) TRD1 recognizes CTA/TAG, and TRD2 recognizes ACA/TGT. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one heteromeric enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	4.25817e-127
NZ_CP048830.1\|WP_000052101.1\|1127541_1128381_-\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	5.5023e-83
NZ_CP048830.1\|WP_000601711.1\|1130339_1132592_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.71214e-45
NZ_CP048830.1\|WP_000026907.1\|1132588_1133221_-\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	2.46863e-100
NZ_CP048830.1\|WP_000061285.1\|1121082_1122234_-\|AAA-family-ATPase	gnl\|CDD\|372509	pfam13166, AAA_13, AAA domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. This family includes the PrrC protein that is thought to be the active component of the anticodon nuclease.	1.80229e-07
NZ_CP048830.1\|WP_000371344.1\|1126897_1127521_-\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	3.66679e-102
NZ_CP048830.1\|WP_000590867.1\|1141395_1142892_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	4.86891e-156
NZ_CP048830.1\|WP_080010676.1\|1136688_1136898_-\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP048830.1\|WP_000199612.1\|1123408_1124950_-\|type-I-restriction-modification-system-subunit-M	gnl\|CDD\|211578	TIGR00497, hsdM, type I restriction system adenine methylase (hsdM). Function: methylation of specific adenine residues; required for both restriction and modification activities. The ECOR124/3 I enzyme recognizes 5'GAA(N7)RTCG. for E.coli see (J. Mol. Biol. 257: 960-969 (1996)). [DNA metabolism, Restriction/modification].	0

>NZ_CP048830.1|WP_000026907.1|1132588_1133221_-|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPELHEHDSLSIQTISGLPDRPGILRLTANSRLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPENFLEAAQKQLNAREISGRVTLLKDPEGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQATGLGGKRRMGCGVFYGDANKVESKAS
>NZ_CP048830.1|WP_000601711.1|1130339_1132592_-|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLRRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWATEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQALIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAEPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWN
>NZ_CP048830.1|WP_000098756.1|1128445_1130332_-|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLSECTSPLLRAGLAGLYSTLHSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVLTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDTSSKSKKSSTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFKSIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEQEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP048830.1|WP_000052101.1|1127541_1128381_-|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGFDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFPGIKAAVEDAKKRIGKSA
>NZ_CP048830.1|WP_000371344.1|1126897_1127521_-|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPITSFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMNHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSGRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFELPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP048830.1|WP_162467460.1|1126200_1126461_+|hypothetical-protein
MKQAQPLLSSQDIFCEGKTIKSGETGTKRKVKSLASWPFLFQERSFKTFDQQTTVLRSVKEKPDINVCFLRFWRELSPNGIKVIFS
>NZ_CP048830.1|WP_000533549.1|1125124_1125307_+|hypothetical-protein
MGRRGKIATEHNASEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK
>NZ_CP048830.1|WP_000199612.1|1123408_1124950_-|type-I-restriction-modification-system-subunit-M
MTSAQQRAALQRQIWQIANDVRGAVDGWDFKQYVLGTLFYRFISENFTNYMEGGDSSIQYSKLNDKKITKEIKDDAIKTRGYFIYPSQLFANIVTKADKNERLNTDLAGIFKDIESSANGFPSEHDIKGLFADFDTTSNRLGNTVKDKNSRLAAVLKRVAELDFGDFDSSHIDLFGDAYEFLISNYAANAGKSGGEFFTPQHVSKLIARLAIHKQTRINKIYDPACGSGSLLLQAKKQFDDHIIEEGFFGQEINHTTYNLARMNMFLHNINYDKFDIELGNTLIDPQHNHEKPFDAIVSNPPYSINWKGSDDPTLINDERFAPAGVLAPKSKADFAFVLHALSYLSSKGRAAIVCFPGIFYRSGAEQKIRQYLVGNNFVETVISLAPNLFFGTTIAVNILVLSKHKTDTNTQFIDASGLFKKETNNNILTEDHIERIMQTFDSKVDTEHFAKSVSVETIANNDYNLSVSSYVEAKDNREVIDIQKLNAELKITVEKIDQLRADIDAIVAEIEG
>NZ_CP048830.1|WP_000083101.1|1122230_1123412_-|restriction-endonuclease-subunit-S
MSQRSFLDQLLDGAKVEWKAVEEIFDLRNGYTPSKSISEYWKDGTIPWFRMEDIRANGQILNNALQKVAKSALKGGKLFPANSIIVATSATIGEHALITVPYLSNQRFTNLILKTEYSDRFEIRFLFYYCFLLDDWCKNNTTMSSFASVDMNGFKKIQIPIPPLPAQEEIVRILDAFTELTTELASELSARKKQYNYYRDQLLSFEEGEVEWKTLGETCDVYTGGEAPESSSMSKTPTDIYKYPIFGNGAEVYGYTDRYRIDKDAVTISSIGANTGTIYFRKAHFTPIIRLKVVIPKQEGILPRYLFHALSSIAIGSKSSSVPNMNAADVKRISIPIPPLAEQERIVDILDKFDALTSSISEGLPREIELRQKQYEYYRELLLSFPKAEAGPK
>NZ_CP048830.1|WP_000061285.1|1121082_1122234_-|AAA-family-ATPase
MSMDIAKLLKDADQKVQLLYAFNGTGKTRLSREFKQLVAPKNNRDEADQAESSHNKILYYNAFTKDLFYWDNDLEKDAEPKLKIQSNSFTDWILKDQGQDRNIITNFQHYTNKKLTPRFNEAYTVKDKNEQEVIVKEFSEVTFSLTRGNEERSGNLKISKGEESNFIWSIFYSLLEQVISVLNVIDSSEQETDQFDQLEYVFIDDPVSSLDENHLIELAAELIQSSKSDIRFLITTHNPLFYNVLHNEFKKDTFKKYILKKQEDESYELANQSTDSPFSYHLHLKAELEKAIETGQLHKYHFNFLRNILEKTSTFVGLERWEDLLSKTEDGDPNPYEVRIINFSSHSKHSDNEVVEVPDEHRRILSFLVKKLDEMYRLRMRTK
>NZ_CP048830.1|WP_000110274.1|1133977_1134184_+|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSLIINLAGIFTRKKNERWPIIR
>NZ_CP048830.1|WP_000683530.1|1134300_1134585_-|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP048830.1|WP_000511225.1|1134584_1136210_-|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADDRVYAGRTLHEELEPNEDFSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP048830.1|WP_080010676.1|1136688_1136898_-|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP048830.1|WP_000578385.1|1137428_1138316_-|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP048830.1|WP_000451419.1|1138577_1138790_+|hypothetical-protein
MEVAFSKVGQPVWFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP048830.1|WP_001072139.1|1138973_1139360_-|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP048830.1|WP_001110347.1|1139702_1140254_-|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIGIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP048830.1|WP_000590867.1|1141395_1142892_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MIKISGLNKAFTTKVLFDDLNLSINRGEKVGLVGRNGHGKSTLFQVILGNVEADSGTISIPKGYKIGHLQQHLHFTKPTVLEECSLGLPEGEEYETWKVEKILSGLGFSEQDMEKNPNEFSGGYQIRMNLAKLLVSSPDMLMLDEPNNYLDIVTIRWLEEFLREWEGEIILVTHDRGFMDAVVTHTIAIHRTKAIKVQGDTDKLYNQINQSEEIYEKTRLNEAKKRKQEEIFIAKFKAKASFASRAQSRVKKLEKQGEMKELEKIQDLELYFNSAPFNANQMLSAENLSFSYDDKEPFLIENFSISVGSRERICIIGKNGKGKSTLLKILAGELETSQGTIKKHPVLKEGYFGQTNKLNLNENSTVVEEIMISDPSCNEWKARTIAGGLMFSEDQALKKIKVLSGGEKSRVLLGKILVTPCHLLYLDEPTNHLDMQSCDSLIEAIDEFDGSVIMVTHDELHLRAVATKLIVFDNDSIQIFNGSYDDFLNDVGWSNEHY
>NZ_CP048830.1|WP_001060166.1|1143456_1144293_-|aldo/keto-reductase
MNNKENPLKQTIMLNNGISMPILGLGVWKTKSGKECKEAVLNALEAGYRHIDTARIYDNEVDVGQAIRESGIPRKEIFITTKLWNADQGSDKTRKALENSLDRLGIDFVDLYLIHFPVTSKRMDSWKELEKLYHDKLCKAIGVSNYTIIHLTELLKNSQITPAVNQVEFHPFLNQIHLLEYCKKHKIQLEAYSPLAHGQKIEDPTIAKIAQKYDKTPAQILIRWAIEQKIVVIPKSIKKERIIENSKVFDFAISEEDMKILNSLDEDFRTCWDPSEVV

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Crispr_ID: NZ_CP048830_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048830_4

1451337-1451433

Orphan

Consensus_repeat	Method
TTCCTAAAGAAATAGGGAATTTAAAAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP048830_4

>merge|NZ_CP048830|4|1451337-1451433|CRISPRCasFinder
TTCCCAAAGAGATAGGCAATTTGAAAAATTTACGTAATTTAGTTTTAGGCAGAAATCAACTTATATCGCTACTCCCTGAAATAGGAAATTTAAAAAA

>NZ_CP048830|4|4|1451337-1451433|CRISPRCasFinder
TTCCCAAAGAGATAGGCAATTTGAAAAA	TTTACGTAATTTAGTTTTAGGCAGAAATCAACTTATATCGC
TACTCCCTGAAATAGGAAATTTAAAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048830.1\|WP_001115367.1\|1461478_1462273_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236594
NZ_CP048830.1\|WP_001026923.1\|1459898_1461464_+\|flagellar-hook-length-control-protein-FliK	unknown	unknown	gnl\|CDD\|350657
NZ_CP048830.1\|WP_000788712.1\|1445847_1446915_+\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|223777
NZ_CP048830.1\|WP_002146174.1\|1443710_1443878_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000051773.1\|1453676_1454198_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237855
NZ_CP048830.1\|WP_001050103.1\|1439326_1440595_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|380169
NZ_CP048830.1\|WP_000465532.1\|1452488_1453625_+\|carbon-nitrogen-hydrolase	unknown	unknown	gnl\|CDD\|143598
NZ_CP048830.1\|WP_000333680.1\|1438350_1438617_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_001132139.1\|1440694_1441741_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000802798.1\|1463929_1465912_+\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|225116
NZ_CP048830.1\|WP_000723318.1\|1457153_1457753_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|310150
NZ_CP048830.1\|WP_000371201.1\|1458113_1458824_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_001158185.1\|1444696_1445791_-\|S-methyl-5-thioribose-1-phosphate-isomerase	unknown	unknown	gnl\|CDD\|223260
NZ_CP048830.1\|WP_001982097.1\|1450250_1450733_+\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
NZ_CP048830.1\|WP_000875156.1\|1447815_1448718_-\|SH3-domain-containing-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000993253.1\|1442034_1443534_+\|DUF342-domain-containing-protein	unknown	unknown	gnl\|CDD\|377177
NZ_CP048830.1\|WP_000453263.1\|1466553_1467012_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000068280.1\|1447119_1447584_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|317965
NZ_CP048830.1\|WP_000986372.1\|1462300_1463695_+\|flagellar-hook-protein-FlgE	unknown	unknown	gnl\|CDD\|235557
NZ_CP048830.1\|WP_000698133.1\|1454977_1455985_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669

Protein	Function_ID	Function_description	E-value
NZ_CP048830.1\|WP_001050103.1\|1439326_1440595_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|380169	NF033161, lipo_LipL41, lipoprotein LipL41. Members of this family are lipoprotein LipL41, as described in Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 but found broadly in the genus Leptospira. Close homologs that are not lipoproteins by sequence are likely defective in their reported coding region.	6.82727e-12
NZ_CP048830.1\|WP_000788712.1\|1445847_1446915_+\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|223777	COG0705, COG0705, Membrane associated serine protease [Amino acid transport and metabolism].	2.78462e-17
NZ_CP048830.1\|WP_000698133.1\|1454977_1455985_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	3.25932e-15
NZ_CP048830.1\|WP_000051773.1\|1453676_1454198_+\|hypothetical-protein	gnl\|CDD\|237855	PRK14900, valS, valyl-tRNA synthetase; Provisional.	1.59265e-08
NZ_CP048830.1\|WP_001026923.1\|1459898_1461464_+\|flagellar-hook-length-control-protein-FliK	gnl\|CDD\|350657	cd17470, T3SS_Flik_C, C-terminal domain of flagellar hook-length control protein FliK and similar domains. The flagellar hook-length control protein FliK is a soluble cytoplasmic protein that is secreted during flagellar formation. It controls hook elongation by two successive events: by determining hook length and by stopping the supply of hook protein. It contains an N-terminal domain that determines hook length and a C-terminal domain that is responsible for switching secretion from the hook protein to that of the filament protein, by interacting with FlhB, the switchable secretion gate.	8.83393e-13
NZ_CP048830.1\|WP_000465532.1\|1452488_1453625_+\|carbon-nitrogen-hydrolase	gnl\|CDD\|143598	cd07574, nitrilase_Rim1_like, Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases). Some members of this subgroup are implicated in post-translational modification, as they contain an N-terminal GCN5-related N-acetyltransferase (GNAT) protein RimI family domain. The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 12. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.	3.28092e-19
NZ_CP048830.1\|WP_000993253.1\|1442034_1443534_+\|DUF342-domain-containing-protein	gnl\|CDD\|377177	pfam03961, FapA, Flagellar Assembly Protein A. Members of this family include FapA (flagellar assembly protein A), found in Vibrio vulnificus. The synthesis of flagella allows bacteria to respond to chemotaxis by facilitating motility. Studies examining the role of FapA show that the loss or delocalization of FapA results in a complete failure of the flagellar biosynthesis and motility in response to glucose mediated chemotaxis. The polar localization of FapA is required for flagellar synthesis, and dephosphorylated EIIAGlc (Glucose-permease IIA component) inhibited the polar localization of FapA through direct interaction.	1.21805e-106
NZ_CP048830.1\|WP_001115367.1\|1461478_1462273_+\|hypothetical-protein	gnl\|CDD\|236594	PRK09618, flgD, flagellar hook assembly protein FlgD.	3.59222e-30
NZ_CP048830.1\|WP_000802798.1\|1463929_1465912_+\|GAF-domain-containing-protein	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	3.75029e-25
NZ_CP048830.1\|WP_000723318.1\|1457153_1457753_+\|hypothetical-protein	gnl\|CDD\|310150	pfam05345, He_PIG, Putative Ig domain. This alignment represents the conserved core region of ~90 residue repeat found in several haemagglutinins and other cell surface proteins. Sequence similarities to (pfam02494) and (pfam00801) suggest an Ig-like fold (personal obs:C. Yeats). So this family may be similar in function to the (pfam02639) and (pfam02638) domains. This domain is also found in the WisP family of proteins of Tropheryma whipplei.	0.00469651
NZ_CP048830.1\|WP_001158185.1\|1444696_1445791_-\|S-methyl-5-thioribose-1-phosphate-isomerase	gnl\|CDD\|223260	COG0182, COG0182, Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis].	6.51899e-149
NZ_CP048830.1\|WP_001982097.1\|1450250_1450733_+\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	1.22185e-15
NZ_CP048830.1\|WP_000068280.1\|1447119_1447584_+\|hypothetical-protein	gnl\|CDD\|317965	pfam15662, SPATA3, Spermatogenesis-associated protein 3 family. The SPATA3 family of proteins is expressed significantly in testis and faintly in epididymis in the ten tissues of testis, ovary, spleen, kidney, lung, heart, brain, epididymis, liver and skeletal muscle in mouse. Members are not expressed in the eight other tissues. This suggests that SPATA3 plays potential roles in spermatogenesis cell apoptosis or spermatogenesis.	0.00530056
NZ_CP048830.1\|WP_000986372.1\|1462300_1463695_+\|flagellar-hook-protein-FlgE	gnl\|CDD\|235557	PRK05682, flgE, flagellar hook protein FlgE; Validated.	1.58159e-151

>NZ_CP048830.1|WP_001982097.1|1450250_1450733_+|rhodanese-like-domain-containing-protein
MAKESDFVKTKRNPIPNRLIDYKKFQNIVNSSAEEREAKRLTEEEFLNMIQDKEVVLLDARSESRYKLRHIKGAVSLPFTEFTKGSLAKVIPKINSKILIYCNNNFTGSPEAFASKAPAASLNLSTFISLKAYGYKNIYELGPLLSVDSTKFTFEGTEVQ
>NZ_CP048830.1|WP_000875156.1|1447815_1448718_-|SH3-domain-containing-protein
MKYILSSIGFVLFLIGNNLISAEIESCFTSYPEVVVRDSPNTSGKKVRIIKQSIPLKILERTSTLEEIKIRNRKVQSNWVKISDGWIFGGLIQCIPKIFFAHPISYHEEELPFSPSDSTNWIAIYLQQESYLRKQISIDLKREHDTVVDQNENIKTGYKVNVINNPIVLIKGITFKKGNFPAITKKVPLELEFGKSYHFNFEKDNYRITSKGKPVQSSGINGYQLILHKNNEEMIIDSRVYRTEKPILVFAGDIDGDGELDFIFDLKDHYNVSNEHLYISSEKINDFFIVPVAANWNTGC
>NZ_CP048830.1|WP_000068280.1|1447119_1447584_+|hypothetical-protein
MAQNKKSALFDILKREKLEKMLKRNSSSGQSQSNEKPQTSVSENVPEKSSTEKKEPQTSKIYKAIEDVKLDIRYYFLQDEYVEKLASIYIKNEGPLEKLGIDPKKYLEYARDSFDRYKQLDKKMPLEPMNKKSWDHVEKSLNELITKLLEKFSK
>NZ_CP048830.1|WP_000788712.1|1445847_1446915_+|rhomboid-family-intramembrane-serine-protease
MKNHSPSPGECGNPGQICPGLALLDSLTTIRILSNMAKRKYRNGISLFGYSIFHPINLILIVNVLVYILQLFAGGTGIIEYYFALTPFRVFHGHYWQVFSYGFLHEAYGIPFIHLFFNMYVFVMFGGLICRYVSAWKFTVVYLTAILTGGITVLLAPVLNEILGIHYPMDLFQTTTLGASGGVTGILVLFGILFPETEVFLVFFRMKARYAAWIFVGGGFVADFVAVYYFHSPFVVSNSCHLGGAIGATLVAPLILKNNFGKIFPKNKDSENTKPTRSLNEDLDFQAQKNLKLLDELSKKISYSDQEDILIPLQQTNVNLCPPPTFQPEDPFCLRCDWLPNCALRKLKTSSEKTP
>NZ_CP048830.1|WP_001158185.1|1444696_1445791_-|S-methyl-5-thioribose-1-phosphate-isomerase
MQESGLKPILWKNKELILLDQRVLPGTTSYITAKTLEDCIFAIREMVVRGAPAIAITGAFGITLYWNSLVSKPSFSELKLKLSELLESRPTAVNLRLAIEEFSSRFPESNYSSFSLEEIQKGAEELALFMLSEDLENNLTLSKYALSLFPKQPSSLNIITHCNTGALATAGHGTALGVIRSLRDAGHSLTVFADETRPYLQGARLTAWELQEEKIQSFLITDNMAGWVMSSRKIDAVIVGADRIASNGDTANKIGTYPLAIVAKHHGVPFYVAATAKSMDFRIPNGSYIPIEMRKEEEITSFGFLKDSDGKPLLKEGVIAPKGMKALNPSFDVTPASLITGIITEKGIVSPVTEENLKKIFQSI
>NZ_CP048830.1|WP_002146174.1|1443710_1443878_-|hypothetical-protein
MALKLSVSLSTDRSTDRVNSAKRFPMGPRLELSRTLSTDRVWNSAERFPMGRVLD
>NZ_CP048830.1|WP_000993253.1|1442034_1443534_+|DUF342-domain-containing-protein
MNANEEPMNTPTPESQISPVSIESAITIVVSTDQLSATITVRPYNLKGTILSKDKLWGVIQDWGIHRDRVLTDEIRKILNLLERAAQKGDFTPIKMEVAKGVAPVPGENGWVRFYHPMSKRVKLLEDGRADFRNIDRYINVKVGEKLATKFEGIPGIPGFDVFGNIIPAPSIKKPKLVVGNHIEERNVIEEGKNLQEYFASSNGVIFATEVSITVSPELQIAGNVGLSTGNIQFDGNVIVRGDVEPGSVVECTGSLVVYGNLESNQIKVGQDLIVHGGIKGSGTEIILVTGRIQTKFIENSYLETEGDIIVEGAILNSTIDTLGSIILNGQNGNLVSSKIRTNEGISVVSLGSSAELDVTVELGFHFKNDRSFQEISRKIQMGEKEMEKILPKIQQIKHMVQRFRGNLPEDKKIAFKVVFEDYNKKLKILNMLKFKQDSLKSSRFNPGAVRLAVQKGAYPGAVIHYRRQIEKITKFQSSFMMVFEPGQEKAIMVALQTK
>NZ_CP048830.1|WP_001132139.1|1440694_1441741_+|hypothetical-protein
MPMNFFSAIRGFPFLIDYSGLKIPKQAHITEISLDLSGSVSLRTKVLENPGNSKKPVIYLQHGMSFKGIDDVRILALGNNLANRGFRVYLPELTEVKNLLIRSETISNIRASFLKIHALEKCPVSYISASFSAGMGFVALADSECQKVLNSALLIGSYSDFVKTLPFVLKNYEIESYAVNVMMYNYIHLIRSEPEGLKKYFLESALDNGLSRKEDSVQGPKVFLNLNEEDKNFLKRFLESSDFRNQLALEIKSIVPETFAKETSPAFFTDHFYRPCFLLHGDDDPVISPQESKDLRNLLLKNGNQKVSFLETSLLTHGDHRPFYSGLNEILPMAKFWGEYLNSVNLLF
>NZ_CP048830.1|WP_001050103.1|1439326_1440595_+|tetratricopeptide-repeat-protein
MNLKRIFIFFLLLCQLHCATFTGTLVNKWVKDYYESTNITGVGIGLAGDGAISVYMGVQFGLAFGLAYAAATIVALPFIFFGLLQPLKVQPVLYFPIFSNDGKDLRGLLQHVPHVIPFYIRPIVIPSHPKESIERELAKSFFSSVYFNFDFLYSFQYLNSISTSKILEHTSIEEIRNDIPRFRKLFNEDFVFISEARLKFGECKLEKISYKEIMKFEERLLSRPVYPREKEDQEETGLMEVQVEIKTYLVDFKNQKIRSFEISETERGYNDFGQRACPDPIRAGKMALKNVGLSHTRKIFPQWKKTKLNLIRNDSDPNVQKLLEEGFQYFGRGDDENHEIFLIKPEALEVWKLALAQSGNRSEGAFANIAYYYLNNGYLEEAIDWFRKAAVANPDREKFWNLRIKDILHKREQVEVYNDLNN
>NZ_CP048830.1|WP_000333680.1|1438350_1438617_-|hypothetical-protein
MCFYLLYLHCFSSFRFETKTAKDNRGDSTSSAQSLLSSFVSDHVAENSTCGKLEIAEHRTEVDKKSHLVFQVFVIGKSACCPQIILKS
>NZ_CP048830.1|WP_000465532.1|1452488_1453625_+|carbon-nitrogen-hydrolase
MFFKRSYLFYFLFLILILYGIWSYTDRSSWEQTPDSRLKRIESFGKNLKKGNLLGIQPWMYPIDYSNEINFSKKIQSYLEEASKNGYINPKTIVVFPEYLGTWLVVAGEKTSVVKSDKLEDSMRTLILSNPVSFIFNFFKAQGKDKIRDALFRMKAEKMLSIYSNTFSGMAKKWGVTIVAGSILLPEPYILEGKIQIRNGALKNVSYVFLPDGRVAENSPEKIYPIEDEKSFVAASTLKNLKIIQSPMGKIGVLVCADSWYPEVYEIFKKQNVNFVVVPSYVAPDGAMSEVWKGYNGSKNPTDIRLEDVHRISEGEAWLKYALAGRILKSGATHGMNVFLRGSLWDLGSDGEIILVHRSMVRTFPKIYGASIVNLWLD
>NZ_CP048830.1|WP_000051773.1|1453676_1454198_+|hypothetical-protein
MSLFLFETFSDNFQSKHNEVTSGKWFGLTSLNLEGKPFAAFFEGSLVLKLGAEKIAEIISRYPGAKLFDPSGNNKAMKDWLQIPAEFEQDWLNLAEDALVFAEKSLSAVAVPAKKKAAPKKAAKKKAPAKKKSPAKKKAAKKKSSAKKAKMKPKAKAKKKVARKKTAAKKRKR
>NZ_CP048830.1|WP_000698133.1|1454977_1455985_-|alpha/beta-hydrolase
MKILKWILGIIGTFALFLVVTFYAETPKYEYKSVPLYSNFDSYYREKLQISRSKKVRPGNEEKLVRYSADKTDFSILYIHGFGASRAEGEEVTDQLAKDFKANLYYVRLPGHGTNLENHRDTTFEEILQDSETAFLECEKLGKKTILIGTSMGGLISTYLAAKYPEKVHALVLVSPFYDFTNPFSVIYQFSWGKDFANIVMGKIRKSTEEEKRNPASAFWYRDQYLAAVQNLSDLREFILGTDPFSKISSPTLLFYYYKNEKNQDVSASVSSMLNAFKKVNENGKANPLNKAVKVEFGNHVLFSKYMKSDKDLILKETETFIQNVFSLNKNLSHN
>NZ_CP048830.1|WP_000723318.1|1457153_1457753_+|hypothetical-protein
MKKIMLILLLFCLVFASCEDEKKDEGSITGNSIMDLLLLQEVSTPPCPGGVTMMDIPSTINAQVGTSVKSPFSIQFSAGSVNHETLMKNKNCNFSELSVTNLPAGLTLNSTTGAINGALTAISAATTVTFSAKLKANNSTPITFTKTTTVTVFAAGSLTCNTAGAALGCNNAALPYSCPNSNFCYSTYSSCKAASECGY
>NZ_CP048830.1|WP_000371201.1|1458113_1458824_+|hypothetical-protein
MDPFEKIVNRYGGWELWNRLDFVEFYFQSLSGPLPFLKGLGKTFNKHGKVRIFPKEFITEFLDYPNPGKKIIFKNGKVGIVNISENLSEFGLSNYKDSFSGLKKYRLWNPLDVSYFFGYATTQYVSIPFILKEYSVRKFELENGDFQIEAEFPSYLHTHCKKQSYRFDSEGLLIRNDYTADIVGSWAKGAHFTTHFQDIEGFPMATKRDVFVRLGSWATSIPVLSAELKPLGVYFR
>NZ_CP048830.1|WP_001026923.1|1459898_1461464_+|flagellar-hook-length-control-protein-FliK
MNISGDLSVSEFKPQQSMRSLPKMGEVAGKNSFVELMKFLQGSAQKGLEETLAEIQNTSSKAELPQPEEEDPEIIEEKKRRSINSIEEEISKEENFETTQEAPNANILPWFLVSETKTNESVDPEIESVILDELQSEIIKTNSTETLNAPESISTSELIENFFTNEVEESTKLLSEVSLKEELENLLDTEKGSLVSFENLKEIKARSTKQESEIYEKSESFEAKDSSDTFRFNEVDKKESKENIKGLSNSFKDKDFEEAKVEVSKELALDSEKWKISRDKKTDSYTNLKTAAKEEIKAVVLNQFTENSFGKSGQEQSFRSDSYSSLVKGVGTTAANGSRESGTFSKEFLPSKESNVLSKKDIQQNFQNLIRSARVQILENGRTEASIRMNPKDLGQMSLAISTDKDVVRGKLLVESDTVKQQLVAELANLKQDLKANGLELESLVIEVKEREDGFSFNADSDKNGKDSHSFQAAFGEDWNSDFKHSFYEEDELSFEENFSEPNDFPKKTDGKSEKLLDLKV
>NZ_CP048830.1|WP_001115367.1|1461478_1462273_+|hypothetical-protein
MPETTGISQQANINRYLEGDRSFNIRNHMENLEKEEKNGLKGIEIRSTVKSLGKDDFLKLLITQLSSQDPTNPVKDQDFIAQMAQFSSLEQMNNISNGIQKMGNRQSFSLVGKLVSGPDFVNGENIAGIAGALFFDGEGKTFVRVNGRSIDVEQISLISDPVVLKEQEAAYNQSQSQQSVPARTPAHSSEIGTNVYPQEAPFDISSNAHEMTTKQKSMESSIKNQKEVEVPGTEQTPELQEKTTSEKKISDWKFPGKDKSNSYE
>NZ_CP048830.1|WP_000986372.1|1462300_1463695_+|flagellar-hook-protein-FlgE
MMRSLYSGVSGLKNHQVRMDVIGNNISNVNTHGFKTERVTFQDMISQELRGASEPKENIGGVNPQQVGLGSLIAAIDKIMTQGSLQTTGKNTDVAISGEGFFIVKDGDKQFYTRAGAFNLDKNGYYVNPANGLKVQGWNSRLDDKGNKYINSAASIEDIIIPVYSKEPARATSQIDFKSNLNSSAPAVPPDATQEEITAMINDPDPKMRRGHVTTINTFDDQGIQREFKMEFYKVRDNTWKARLSMTDSTQLSVDVSGTGGQNTQLPGNTELEFGFTPDGKLVYVSDGVDSMNSGKLNAKVSFRIPGNPAIQNFDLNLGEAGMVNGITQFSSDFTTKAVKQDGYTMGYLESFSIDNSGTITGVFSNGVRQPLARVATAVFNNPAGLDKAGDTMFSYSMNSGEPNIGEAGVQGRGKINAGLLEMSNVDLSDQFTDMIVTQRGFQANSRTITTSDQMIQEVLGLKR
>NZ_CP048830.1|WP_000802798.1|1463929_1465912_+|GAF-domain-containing-protein
MKPKFPKYIVTDLDSIVKRLGPIISRLEIEFLDFKEFFQSELFRNSSGFLNVIFYLTVSDLKKTQKEIHQQFQRNPLILSRFILNENLDYVHSEDLKIEEELIFSVLPESSSDMVFNKTFLNAFTQLQMITDQFDLQHKVNTTKYEISKLTRVGISLADEKDINKLLREIIFSAREIAIADSGSLYLVEKDELGLVRNLRFKISSMDIDTEEFLLPINKSSVAGYVAATGKILNIPDVYNLPEDSEYKFNRNFDVLSNYHTKSMLVVPMKNHRNEVVGVIQLINKKRNFNQKLTLEQMRGNDVFPFDDYSAQLVMGVAGQAAVAIQNNHLLQEIEALFEGFVTASVNAIESRDPTTSGHSFRVAVLTVGLAETVDLIREGKYKNTKFSKEQIKEIRYASLLHDFGKVGVREKVLVKSKKLEDYELELIRWRFEYIKKDIESRILQKKTDYLKKHGAVGFADYETSLEFELKVEYQKLDQMFQIVVDSNEPSILEESNFQKLEEIAKVNYSTTGGEKLSLISPYEFGFLTIKKGSLDFAERKEIESHVEHTFQFLSKIPWTGDLKMVPSIAHAHHEKLDGTGYPRGLTADSIPIQSKIMAISDIFDALTDKDRPYKRAVPIERALDILQMEARENHVDQDLLKIFIEGKVYDKLYYSGYLR
>NZ_CP048830.1|WP_000453263.1|1466553_1467012_-|hypothetical-protein
MEVKSLKRKAVCNLVFSEMYKNKTYFSNYGSKFLRTEPEKRNNLTPNNKNAIYHLLKFKITEQLFTNYYLNLNYYIKQYFSIGVYFKIYVTLLISTKSRILNFYYKTLFQNKIFGTLLYSSGQYTRIHRIQKVLHLSNLRRVTITTAQYLQV

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Crispr_ID: NZ_CP048830_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048830_3

1450923-1451227

Orphan

Consensus_repeat	Method
TTCCTAAAGAAATAGGGAATTTAAAAAA	CRISPRCasFinder

4 spacers

The CRISPR arrays of NZ_CP048830_3

>merge|NZ_CP048830|3|1450923-1451227|CRISPRCasFinder
TTCCAAAGGAAATTGGAAACTTACAAAATTTAAAAGAATTATATTTAAGCGCGAACGAAATTACAACTCTGCCTCCTGAAATAGGAAATTTAAAAAACTTACAGGTATTGTCTTTAAATGGAAACAGACTTGAAACAATTCCTAAAGAAATAGGGAATTTAAAAAAACTAAAAGAACTGTCGATAGAATGGAATAAACTTCAAACACTTCCTAAAGAAATAGGAAATTTAAAAAACTTAAAAGAATTATATTTAAGCAGAAATCAACTCAAAATATTACCGCAAGAAATCGGGAACTTAAGAAAA

>NZ_CP048830|3|3|1450923-1451227|CRISPRCasFinder
TTCCAAAGGAAATTGGAAACTTACAAAA	TTTAAAAGAATTATATTTAAGCGCGAACGAAATTACAACTC
TGCCTCCTGAAATAGGAAATTTAAAAAA	CTTACAGGTATTGTCTTTAAATGGAAACAGACTTGAAACAA
TTCCTAAAGAAATAGGGAATTTAAAAAA	ACTAAAAGAACTGTCGATAGAATGGAATAAACTTCAAACAC
TTCCTAAAGAAATAGGAAATTTAAAAAA	CTTAAAAGAATTATATTTAAGCAGAAATCAACTCAAAATAT
TACCGCAAGAAATCGGGAACTTAAGAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048830.1\|WP_001115367.1\|1461478_1462273_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236594
NZ_CP048830.1\|WP_001026923.1\|1459898_1461464_+\|flagellar-hook-length-control-protein-FliK	unknown	unknown	gnl\|CDD\|350657
NZ_CP048830.1\|WP_000788712.1\|1445847_1446915_+\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|223777
NZ_CP048830.1\|WP_002146174.1\|1443710_1443878_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000051773.1\|1453676_1454198_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237855
NZ_CP048830.1\|WP_001050103.1\|1439326_1440595_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|380169
NZ_CP048830.1\|WP_000465532.1\|1452488_1453625_+\|carbon-nitrogen-hydrolase	unknown	unknown	gnl\|CDD\|143598
NZ_CP048830.1\|WP_000333680.1\|1438350_1438617_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_001132139.1\|1440694_1441741_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000802798.1\|1463929_1465912_+\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|225116
NZ_CP048830.1\|WP_000723318.1\|1457153_1457753_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|310150
NZ_CP048830.1\|WP_000371201.1\|1458113_1458824_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_001158185.1\|1444696_1445791_-\|S-methyl-5-thioribose-1-phosphate-isomerase	unknown	unknown	gnl\|CDD\|223260
NZ_CP048830.1\|WP_001982097.1\|1450250_1450733_+\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
NZ_CP048830.1\|WP_000875156.1\|1447815_1448718_-\|SH3-domain-containing-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000993253.1\|1442034_1443534_+\|DUF342-domain-containing-protein	unknown	unknown	gnl\|CDD\|377177
NZ_CP048830.1\|WP_000453263.1\|1466553_1467012_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000068280.1\|1447119_1447584_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|317965
NZ_CP048830.1\|WP_000986372.1\|1462300_1463695_+\|flagellar-hook-protein-FlgE	unknown	unknown	gnl\|CDD\|235557
NZ_CP048830.1\|WP_000698133.1\|1454977_1455985_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669

Protein	Function_ID	Function_description	E-value
NZ_CP048830.1\|WP_001050103.1\|1439326_1440595_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|380169	NF033161, lipo_LipL41, lipoprotein LipL41. Members of this family are lipoprotein LipL41, as described in Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 but found broadly in the genus Leptospira. Close homologs that are not lipoproteins by sequence are likely defective in their reported coding region.	6.82727e-12
NZ_CP048830.1\|WP_000788712.1\|1445847_1446915_+\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|223777	COG0705, COG0705, Membrane associated serine protease [Amino acid transport and metabolism].	2.78462e-17
NZ_CP048830.1\|WP_000698133.1\|1454977_1455985_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	3.25932e-15
NZ_CP048830.1\|WP_000051773.1\|1453676_1454198_+\|hypothetical-protein	gnl\|CDD\|237855	PRK14900, valS, valyl-tRNA synthetase; Provisional.	1.59265e-08
NZ_CP048830.1\|WP_001026923.1\|1459898_1461464_+\|flagellar-hook-length-control-protein-FliK	gnl\|CDD\|350657	cd17470, T3SS_Flik_C, C-terminal domain of flagellar hook-length control protein FliK and similar domains. The flagellar hook-length control protein FliK is a soluble cytoplasmic protein that is secreted during flagellar formation. It controls hook elongation by two successive events: by determining hook length and by stopping the supply of hook protein. It contains an N-terminal domain that determines hook length and a C-terminal domain that is responsible for switching secretion from the hook protein to that of the filament protein, by interacting with FlhB, the switchable secretion gate.	8.83393e-13
NZ_CP048830.1\|WP_000465532.1\|1452488_1453625_+\|carbon-nitrogen-hydrolase	gnl\|CDD\|143598	cd07574, nitrilase_Rim1_like, Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases). Some members of this subgroup are implicated in post-translational modification, as they contain an N-terminal GCN5-related N-acetyltransferase (GNAT) protein RimI family domain. The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 12. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.	3.28092e-19
NZ_CP048830.1\|WP_000993253.1\|1442034_1443534_+\|DUF342-domain-containing-protein	gnl\|CDD\|377177	pfam03961, FapA, Flagellar Assembly Protein A. Members of this family include FapA (flagellar assembly protein A), found in Vibrio vulnificus. The synthesis of flagella allows bacteria to respond to chemotaxis by facilitating motility. Studies examining the role of FapA show that the loss or delocalization of FapA results in a complete failure of the flagellar biosynthesis and motility in response to glucose mediated chemotaxis. The polar localization of FapA is required for flagellar synthesis, and dephosphorylated EIIAGlc (Glucose-permease IIA component) inhibited the polar localization of FapA through direct interaction.	1.21805e-106
NZ_CP048830.1\|WP_001115367.1\|1461478_1462273_+\|hypothetical-protein	gnl\|CDD\|236594	PRK09618, flgD, flagellar hook assembly protein FlgD.	3.59222e-30
NZ_CP048830.1\|WP_000802798.1\|1463929_1465912_+\|GAF-domain-containing-protein	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	3.75029e-25
NZ_CP048830.1\|WP_000723318.1\|1457153_1457753_+\|hypothetical-protein	gnl\|CDD\|310150	pfam05345, He_PIG, Putative Ig domain. This alignment represents the conserved core region of ~90 residue repeat found in several haemagglutinins and other cell surface proteins. Sequence similarities to (pfam02494) and (pfam00801) suggest an Ig-like fold (personal obs:C. Yeats). So this family may be similar in function to the (pfam02639) and (pfam02638) domains. This domain is also found in the WisP family of proteins of Tropheryma whipplei.	0.00469651
NZ_CP048830.1\|WP_001158185.1\|1444696_1445791_-\|S-methyl-5-thioribose-1-phosphate-isomerase	gnl\|CDD\|223260	COG0182, COG0182, Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis].	6.51899e-149
NZ_CP048830.1\|WP_001982097.1\|1450250_1450733_+\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	1.22185e-15
NZ_CP048830.1\|WP_000068280.1\|1447119_1447584_+\|hypothetical-protein	gnl\|CDD\|317965	pfam15662, SPATA3, Spermatogenesis-associated protein 3 family. The SPATA3 family of proteins is expressed significantly in testis and faintly in epididymis in the ten tissues of testis, ovary, spleen, kidney, lung, heart, brain, epididymis, liver and skeletal muscle in mouse. Members are not expressed in the eight other tissues. This suggests that SPATA3 plays potential roles in spermatogenesis cell apoptosis or spermatogenesis.	0.00530056
NZ_CP048830.1\|WP_000986372.1\|1462300_1463695_+\|flagellar-hook-protein-FlgE	gnl\|CDD\|235557	PRK05682, flgE, flagellar hook protein FlgE; Validated.	1.58159e-151

>NZ_CP048830.1|WP_001982097.1|1450250_1450733_+|rhodanese-like-domain-containing-protein
MAKESDFVKTKRNPIPNRLIDYKKFQNIVNSSAEEREAKRLTEEEFLNMIQDKEVVLLDARSESRYKLRHIKGAVSLPFTEFTKGSLAKVIPKINSKILIYCNNNFTGSPEAFASKAPAASLNLSTFISLKAYGYKNIYELGPLLSVDSTKFTFEGTEVQ
>NZ_CP048830.1|WP_000875156.1|1447815_1448718_-|SH3-domain-containing-protein
MKYILSSIGFVLFLIGNNLISAEIESCFTSYPEVVVRDSPNTSGKKVRIIKQSIPLKILERTSTLEEIKIRNRKVQSNWVKISDGWIFGGLIQCIPKIFFAHPISYHEEELPFSPSDSTNWIAIYLQQESYLRKQISIDLKREHDTVVDQNENIKTGYKVNVINNPIVLIKGITFKKGNFPAITKKVPLELEFGKSYHFNFEKDNYRITSKGKPVQSSGINGYQLILHKNNEEMIIDSRVYRTEKPILVFAGDIDGDGELDFIFDLKDHYNVSNEHLYISSEKINDFFIVPVAANWNTGC
>NZ_CP048830.1|WP_000068280.1|1447119_1447584_+|hypothetical-protein
MAQNKKSALFDILKREKLEKMLKRNSSSGQSQSNEKPQTSVSENVPEKSSTEKKEPQTSKIYKAIEDVKLDIRYYFLQDEYVEKLASIYIKNEGPLEKLGIDPKKYLEYARDSFDRYKQLDKKMPLEPMNKKSWDHVEKSLNELITKLLEKFSK
>NZ_CP048830.1|WP_000788712.1|1445847_1446915_+|rhomboid-family-intramembrane-serine-protease
MKNHSPSPGECGNPGQICPGLALLDSLTTIRILSNMAKRKYRNGISLFGYSIFHPINLILIVNVLVYILQLFAGGTGIIEYYFALTPFRVFHGHYWQVFSYGFLHEAYGIPFIHLFFNMYVFVMFGGLICRYVSAWKFTVVYLTAILTGGITVLLAPVLNEILGIHYPMDLFQTTTLGASGGVTGILVLFGILFPETEVFLVFFRMKARYAAWIFVGGGFVADFVAVYYFHSPFVVSNSCHLGGAIGATLVAPLILKNNFGKIFPKNKDSENTKPTRSLNEDLDFQAQKNLKLLDELSKKISYSDQEDILIPLQQTNVNLCPPPTFQPEDPFCLRCDWLPNCALRKLKTSSEKTP
>NZ_CP048830.1|WP_001158185.1|1444696_1445791_-|S-methyl-5-thioribose-1-phosphate-isomerase
MQESGLKPILWKNKELILLDQRVLPGTTSYITAKTLEDCIFAIREMVVRGAPAIAITGAFGITLYWNSLVSKPSFSELKLKLSELLESRPTAVNLRLAIEEFSSRFPESNYSSFSLEEIQKGAEELALFMLSEDLENNLTLSKYALSLFPKQPSSLNIITHCNTGALATAGHGTALGVIRSLRDAGHSLTVFADETRPYLQGARLTAWELQEEKIQSFLITDNMAGWVMSSRKIDAVIVGADRIASNGDTANKIGTYPLAIVAKHHGVPFYVAATAKSMDFRIPNGSYIPIEMRKEEEITSFGFLKDSDGKPLLKEGVIAPKGMKALNPSFDVTPASLITGIITEKGIVSPVTEENLKKIFQSI
>NZ_CP048830.1|WP_002146174.1|1443710_1443878_-|hypothetical-protein
MALKLSVSLSTDRSTDRVNSAKRFPMGPRLELSRTLSTDRVWNSAERFPMGRVLD
>NZ_CP048830.1|WP_000993253.1|1442034_1443534_+|DUF342-domain-containing-protein
MNANEEPMNTPTPESQISPVSIESAITIVVSTDQLSATITVRPYNLKGTILSKDKLWGVIQDWGIHRDRVLTDEIRKILNLLERAAQKGDFTPIKMEVAKGVAPVPGENGWVRFYHPMSKRVKLLEDGRADFRNIDRYINVKVGEKLATKFEGIPGIPGFDVFGNIIPAPSIKKPKLVVGNHIEERNVIEEGKNLQEYFASSNGVIFATEVSITVSPELQIAGNVGLSTGNIQFDGNVIVRGDVEPGSVVECTGSLVVYGNLESNQIKVGQDLIVHGGIKGSGTEIILVTGRIQTKFIENSYLETEGDIIVEGAILNSTIDTLGSIILNGQNGNLVSSKIRTNEGISVVSLGSSAELDVTVELGFHFKNDRSFQEISRKIQMGEKEMEKILPKIQQIKHMVQRFRGNLPEDKKIAFKVVFEDYNKKLKILNMLKFKQDSLKSSRFNPGAVRLAVQKGAYPGAVIHYRRQIEKITKFQSSFMMVFEPGQEKAIMVALQTK
>NZ_CP048830.1|WP_001132139.1|1440694_1441741_+|hypothetical-protein
MPMNFFSAIRGFPFLIDYSGLKIPKQAHITEISLDLSGSVSLRTKVLENPGNSKKPVIYLQHGMSFKGIDDVRILALGNNLANRGFRVYLPELTEVKNLLIRSETISNIRASFLKIHALEKCPVSYISASFSAGMGFVALADSECQKVLNSALLIGSYSDFVKTLPFVLKNYEIESYAVNVMMYNYIHLIRSEPEGLKKYFLESALDNGLSRKEDSVQGPKVFLNLNEEDKNFLKRFLESSDFRNQLALEIKSIVPETFAKETSPAFFTDHFYRPCFLLHGDDDPVISPQESKDLRNLLLKNGNQKVSFLETSLLTHGDHRPFYSGLNEILPMAKFWGEYLNSVNLLF
>NZ_CP048830.1|WP_001050103.1|1439326_1440595_+|tetratricopeptide-repeat-protein
MNLKRIFIFFLLLCQLHCATFTGTLVNKWVKDYYESTNITGVGIGLAGDGAISVYMGVQFGLAFGLAYAAATIVALPFIFFGLLQPLKVQPVLYFPIFSNDGKDLRGLLQHVPHVIPFYIRPIVIPSHPKESIERELAKSFFSSVYFNFDFLYSFQYLNSISTSKILEHTSIEEIRNDIPRFRKLFNEDFVFISEARLKFGECKLEKISYKEIMKFEERLLSRPVYPREKEDQEETGLMEVQVEIKTYLVDFKNQKIRSFEISETERGYNDFGQRACPDPIRAGKMALKNVGLSHTRKIFPQWKKTKLNLIRNDSDPNVQKLLEEGFQYFGRGDDENHEIFLIKPEALEVWKLALAQSGNRSEGAFANIAYYYLNNGYLEEAIDWFRKAAVANPDREKFWNLRIKDILHKREQVEVYNDLNN
>NZ_CP048830.1|WP_000333680.1|1438350_1438617_-|hypothetical-protein
MCFYLLYLHCFSSFRFETKTAKDNRGDSTSSAQSLLSSFVSDHVAENSTCGKLEIAEHRTEVDKKSHLVFQVFVIGKSACCPQIILKS
>NZ_CP048830.1|WP_000465532.1|1452488_1453625_+|carbon-nitrogen-hydrolase
MFFKRSYLFYFLFLILILYGIWSYTDRSSWEQTPDSRLKRIESFGKNLKKGNLLGIQPWMYPIDYSNEINFSKKIQSYLEEASKNGYINPKTIVVFPEYLGTWLVVAGEKTSVVKSDKLEDSMRTLILSNPVSFIFNFFKAQGKDKIRDALFRMKAEKMLSIYSNTFSGMAKKWGVTIVAGSILLPEPYILEGKIQIRNGALKNVSYVFLPDGRVAENSPEKIYPIEDEKSFVAASTLKNLKIIQSPMGKIGVLVCADSWYPEVYEIFKKQNVNFVVVPSYVAPDGAMSEVWKGYNGSKNPTDIRLEDVHRISEGEAWLKYALAGRILKSGATHGMNVFLRGSLWDLGSDGEIILVHRSMVRTFPKIYGASIVNLWLD
>NZ_CP048830.1|WP_000051773.1|1453676_1454198_+|hypothetical-protein
MSLFLFETFSDNFQSKHNEVTSGKWFGLTSLNLEGKPFAAFFEGSLVLKLGAEKIAEIISRYPGAKLFDPSGNNKAMKDWLQIPAEFEQDWLNLAEDALVFAEKSLSAVAVPAKKKAAPKKAAKKKAPAKKKSPAKKKAAKKKSSAKKAKMKPKAKAKKKVARKKTAAKKRKR
>NZ_CP048830.1|WP_000698133.1|1454977_1455985_-|alpha/beta-hydrolase
MKILKWILGIIGTFALFLVVTFYAETPKYEYKSVPLYSNFDSYYREKLQISRSKKVRPGNEEKLVRYSADKTDFSILYIHGFGASRAEGEEVTDQLAKDFKANLYYVRLPGHGTNLENHRDTTFEEILQDSETAFLECEKLGKKTILIGTSMGGLISTYLAAKYPEKVHALVLVSPFYDFTNPFSVIYQFSWGKDFANIVMGKIRKSTEEEKRNPASAFWYRDQYLAAVQNLSDLREFILGTDPFSKISSPTLLFYYYKNEKNQDVSASVSSMLNAFKKVNENGKANPLNKAVKVEFGNHVLFSKYMKSDKDLILKETETFIQNVFSLNKNLSHN
>NZ_CP048830.1|WP_000723318.1|1457153_1457753_+|hypothetical-protein
MKKIMLILLLFCLVFASCEDEKKDEGSITGNSIMDLLLLQEVSTPPCPGGVTMMDIPSTINAQVGTSVKSPFSIQFSAGSVNHETLMKNKNCNFSELSVTNLPAGLTLNSTTGAINGALTAISAATTVTFSAKLKANNSTPITFTKTTTVTVFAAGSLTCNTAGAALGCNNAALPYSCPNSNFCYSTYSSCKAASECGY
>NZ_CP048830.1|WP_000371201.1|1458113_1458824_+|hypothetical-protein
MDPFEKIVNRYGGWELWNRLDFVEFYFQSLSGPLPFLKGLGKTFNKHGKVRIFPKEFITEFLDYPNPGKKIIFKNGKVGIVNISENLSEFGLSNYKDSFSGLKKYRLWNPLDVSYFFGYATTQYVSIPFILKEYSVRKFELENGDFQIEAEFPSYLHTHCKKQSYRFDSEGLLIRNDYTADIVGSWAKGAHFTTHFQDIEGFPMATKRDVFVRLGSWATSIPVLSAELKPLGVYFR
>NZ_CP048830.1|WP_001026923.1|1459898_1461464_+|flagellar-hook-length-control-protein-FliK
MNISGDLSVSEFKPQQSMRSLPKMGEVAGKNSFVELMKFLQGSAQKGLEETLAEIQNTSSKAELPQPEEEDPEIIEEKKRRSINSIEEEISKEENFETTQEAPNANILPWFLVSETKTNESVDPEIESVILDELQSEIIKTNSTETLNAPESISTSELIENFFTNEVEESTKLLSEVSLKEELENLLDTEKGSLVSFENLKEIKARSTKQESEIYEKSESFEAKDSSDTFRFNEVDKKESKENIKGLSNSFKDKDFEEAKVEVSKELALDSEKWKISRDKKTDSYTNLKTAAKEEIKAVVLNQFTENSFGKSGQEQSFRSDSYSSLVKGVGTTAANGSRESGTFSKEFLPSKESNVLSKKDIQQNFQNLIRSARVQILENGRTEASIRMNPKDLGQMSLAISTDKDVVRGKLLVESDTVKQQLVAELANLKQDLKANGLELESLVIEVKEREDGFSFNADSDKNGKDSHSFQAAFGEDWNSDFKHSFYEEDELSFEENFSEPNDFPKKTDGKSEKLLDLKV
>NZ_CP048830.1|WP_001115367.1|1461478_1462273_+|hypothetical-protein
MPETTGISQQANINRYLEGDRSFNIRNHMENLEKEEKNGLKGIEIRSTVKSLGKDDFLKLLITQLSSQDPTNPVKDQDFIAQMAQFSSLEQMNNISNGIQKMGNRQSFSLVGKLVSGPDFVNGENIAGIAGALFFDGEGKTFVRVNGRSIDVEQISLISDPVVLKEQEAAYNQSQSQQSVPARTPAHSSEIGTNVYPQEAPFDISSNAHEMTTKQKSMESSIKNQKEVEVPGTEQTPELQEKTTSEKKISDWKFPGKDKSNSYE
>NZ_CP048830.1|WP_000986372.1|1462300_1463695_+|flagellar-hook-protein-FlgE
MMRSLYSGVSGLKNHQVRMDVIGNNISNVNTHGFKTERVTFQDMISQELRGASEPKENIGGVNPQQVGLGSLIAAIDKIMTQGSLQTTGKNTDVAISGEGFFIVKDGDKQFYTRAGAFNLDKNGYYVNPANGLKVQGWNSRLDDKGNKYINSAASIEDIIIPVYSKEPARATSQIDFKSNLNSSAPAVPPDATQEEITAMINDPDPKMRRGHVTTINTFDDQGIQREFKMEFYKVRDNTWKARLSMTDSTQLSVDVSGTGGQNTQLPGNTELEFGFTPDGKLVYVSDGVDSMNSGKLNAKVSFRIPGNPAIQNFDLNLGEAGMVNGITQFSSDFTTKAVKQDGYTMGYLESFSIDNSGTITGVFSNGVRQPLARVATAVFNNPAGLDKAGDTMFSYSMNSGEPNIGEAGVQGRGKINAGLLEMSNVDLSDQFTDMIVTQRGFQANSRTITTSDQMIQEVLGLKR
>NZ_CP048830.1|WP_000802798.1|1463929_1465912_+|GAF-domain-containing-protein
MKPKFPKYIVTDLDSIVKRLGPIISRLEIEFLDFKEFFQSELFRNSSGFLNVIFYLTVSDLKKTQKEIHQQFQRNPLILSRFILNENLDYVHSEDLKIEEELIFSVLPESSSDMVFNKTFLNAFTQLQMITDQFDLQHKVNTTKYEISKLTRVGISLADEKDINKLLREIIFSAREIAIADSGSLYLVEKDELGLVRNLRFKISSMDIDTEEFLLPINKSSVAGYVAATGKILNIPDVYNLPEDSEYKFNRNFDVLSNYHTKSMLVVPMKNHRNEVVGVIQLINKKRNFNQKLTLEQMRGNDVFPFDDYSAQLVMGVAGQAAVAIQNNHLLQEIEALFEGFVTASVNAIESRDPTTSGHSFRVAVLTVGLAETVDLIREGKYKNTKFSKEQIKEIRYASLLHDFGKVGVREKVLVKSKKLEDYELELIRWRFEYIKKDIESRILQKKTDYLKKHGAVGFADYETSLEFELKVEYQKLDQMFQIVVDSNEPSILEESNFQKLEEIAKVNYSTTGGEKLSLISPYEFGFLTIKKGSLDFAERKEIESHVEHTFQFLSKIPWTGDLKMVPSIAHAHHEKLDGTGYPRGLTADSIPIQSKIMAISDIFDALTDKDRPYKRAVPIERALDILQMEARENHVDQDLLKIFIEGKVYDKLYYSGYLR
>NZ_CP048830.1|WP_000453263.1|1466553_1467012_-|hypothetical-protein
MEVKSLKRKAVCNLVFSEMYKNKTYFSNYGSKFLRTEPEKRNNLTPNNKNAIYHLLKFKITEQLFTNYYLNLNYYIKQYFSIGVYFKIYVTLLISTKSRILNFYYKTLFQNKIFGTLLYSSGQYTRIHRIQKVLHLSNLRRVTITTAQYLQV

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Crispr_ID: NZ_CP048830_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048830_5

1615015-1615108

Orphan

Consensus_repeat	Method
AGGAAAGCGTTGTGTTGAGTTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP048830_5

>merge|NZ_CP048830|5|1615015-1615108|CRISPRCasFinder
AGGAAAGCGTTGTGTTGAGTTTTCCAACGCGACCTGCAGAGCGACCCTTAGGGAGCGATGCATTGAGTTTGAGGAAAGCGTTGTGTTGAGTTTT

>NZ_CP048830|5|5|1615015-1615108|CRISPRCasFinder
AGGAAAGCGTTGTGTTGAGTTTT	CCAACGCGACCTGCAGAGCGACCCTTAGGGAGCGATGCATTGAGTTTG
AGGAAAGCGTTGTGTTGAGTTTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048830.1\|WP_001016365.1\|1615274_1616387_-\|acetylglutamate-kinase	unknown	unknown	gnl\|CDD\|235306
NZ_CP048830.1\|WP_000287368.1\|1618263_1619382_+\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238425
NZ_CP048830.1\|WP_001113397.1\|1608861_1609671_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|214905
NZ_CP048830.1\|WP_000205143.1\|1620423_1621713_+\|M24-family-metallopeptidase	unknown	unknown	gnl\|CDD\|238520
NZ_CP048830.1\|WP_001038596.1\|1611715_1612840_+\|D-alanine--D-alanine-ligase	unknown	unknown	gnl\|CDD\|273498
NZ_CP048830.1\|WP_001190719.1\|1612852_1613539_+\|iron-containing-redox-enzyme-family-protein	unknown	unknown	gnl\|CDD\|379634
NZ_CP048830.1\|WP_000146501.1\|1605199_1606303_+\|dehypoxanthine-futalosine-cyclase	unknown	unknown	gnl\|CDD\|274731
NZ_CP048830.1\|WP_001097889.1\|1610472_1611723_+\|KamA-family-radical-SAM-protein	unknown	unknown	gnl\|CDD\|224426
NZ_CP048830.1\|WP_000181059.1\|1616402_1617653_-\|N-6-DNA-methylase	unknown	unknown	gnl\|CDD\|236981
NZ_CP048830.1\|WP_001967602.1\|1619395_1620427_+\|glycosyltransferase-family-9-protein	unknown	unknown	gnl\|CDD\|340821
NZ_CP048830.1\|WP_002068674.1\|1604772_1604934_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000591544.1\|1622064_1622628_+\|DUF1564-family-protein	unknown	unknown	gnl\|CDD\|284922
NZ_CP048830.1\|WP_033108311.1\|1624230_1626420_+\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP048830.1\|WP_134795163.1\|1626388_1626547_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000583497.1\|1623353_1623890_+\|DUF1564-family-protein	unknown	unknown	gnl\|CDD\|284922
NZ_CP048830.1\|WP_000677991.1\|1617649_1618117_-\|bacterioferritin	unknown	unknown	gnl\|CDD\|153099
NZ_CP048830.1\|WP_000215708.1\|1609714_1610389_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223620
NZ_CP048830.1\|WP_001227922.1\|1602667_1603723_+\|bifunctional-glycosyltransferase-family-2/GtrA-family-protein	unknown	unknown	gnl\|CDD\|133022
NZ_CP048830.1\|WP_001239790.1\|1607518_1608748_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NZ_CP048830.1\|WP_000173137.1\|1607130_1607535_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP048830.1\|WP_001016365.1\|1615274_1616387_-\|acetylglutamate-kinase	gnl\|CDD\|235306	PRK04531, PRK04531, acetylglutamate kinase; Provisional.	0
NZ_CP048830.1\|WP_000287368.1\|1618263_1619382_+\|thiolase-family-protein	gnl\|CDD\|238425	cd00829, SCP-x_thiolase, Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein.	2.29943e-91
NZ_CP048830.1\|WP_001113397.1\|1608861_1609671_-\|hypothetical-protein	gnl\|CDD\|214905	smart00909, Germane, Sporulation and spore germination. The GerMN domain is a region of approximately 100 residues that is found, duplicated, in the Bacillus GerM protein and is implicated in both sporulation and spore germination. The domain is found in a number of different bacterial species both alone and in association with other domains such as Amidase_3 pfam01520 Gmad1 and Gmad2. It is predicted to have a novel alpha-beta fold.	1.14648e-11
NZ_CP048830.1\|WP_000205143.1\|1620423_1621713_+\|M24-family-metallopeptidase	gnl\|CDD\|238520	cd01087, Prolidase, Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.	2.08187e-122
NZ_CP048830.1\|WP_001038596.1\|1611715_1612840_+\|D-alanine--D-alanine-ligase	gnl\|CDD\|273498	TIGR01205, D-alanine--D-alanine_ligase, D-alanine--D-alanine ligase. This model describes D-Ala--D-Ala ligase, an enzyme that makes a required precursor of the bacterial cell wall. It also describes some closely related proteins responsible for resistance to glycopeptide antibiotics such as vancomycin. The mechanism of glyopeptide antibiotic resistance involves the production of D-alanine-D-lactate (VanA and VanB families) or D-alanine-D-serine (VanC). The seed alignment contains only chromosomally encoded D-ala--D-ala ligases, but a number of antibiotic resistance proteins score above the trusted cutoff of this model. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	1.91794e-23
NZ_CP048830.1\|WP_001190719.1\|1612852_1613539_+\|iron-containing-redox-enzyme-family-protein	gnl\|CDD\|379634	pfam14518, Haem_oxygenas_2, Iron-containing redox enzyme. The CADD, Chlamydia protein associating with death domains, crystal structure reveals a dimer of seven-helical bundles. Each bundle contains a di-iron centre adjacent to an internal cavity that forms an active site similar to that of methane mono-oxygenase hydrolase.	4.37451e-24
NZ_CP048830.1\|WP_000146501.1\|1605199_1606303_+\|dehypoxanthine-futalosine-cyclase	gnl\|CDD\|274731	TIGR03699, menaquin_MqnC, dehypoxanthine futalosine cyclase. members of this protein family are involved in menaquinone biosynthesis by an alternate pathway via futalosine. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	0
NZ_CP048830.1\|WP_001097889.1\|1610472_1611723_+\|KamA-family-radical-SAM-protein	gnl\|CDD\|224426	COG1509, KamA, Lysine 2,3-aminomutase [Amino acid transport and metabolism].	1.39435e-125
NZ_CP048830.1\|WP_000181059.1\|1616402_1617653_-\|N-6-DNA-methylase	gnl\|CDD\|236981	PRK11783, rlmL, bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL.	1.77761e-83
NZ_CP048830.1\|WP_001967602.1\|1619395_1620427_+\|glycosyltransferase-family-9-protein	gnl\|CDD\|340821	cd03789, GT9_LPS_heptosyltransferase, lipopolysaccharide heptosyltransferase and similar proteins. Lipopolysaccharide heptosyltransferase (2.4.99.B6) is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from ADP-heptose to 3-deoxy-D-manno-octulosonic acid (KDO), a part of the inner core component of LPS. This family also contains lipopolysaccharide 1,2-N-acetylglucosaminetransferase EC 2.4.1.56 and belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	1.20319e-66
NZ_CP048830.1\|WP_000591544.1\|1622064_1622628_+\|DUF1564-family-protein	gnl\|CDD\|284922	pfam07600, DUF1564, Protein of unknown function (DUF1564). A family of paralogous proteins in Leptospira interrogans. Several have been annotated as possible CopG-like transcriptional regulators (see pfam01402).	6.21791e-12
NZ_CP048830.1\|WP_033108311.1\|1624230_1626420_+\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.95364e-27
NZ_CP048830.1\|WP_000583497.1\|1623353_1623890_+\|DUF1564-family-protein	gnl\|CDD\|284922	pfam07600, DUF1564, Protein of unknown function (DUF1564). A family of paralogous proteins in Leptospira interrogans. Several have been annotated as possible CopG-like transcriptional regulators (see pfam01402).	5.3303e-08
NZ_CP048830.1\|WP_000677991.1\|1617649_1618117_-\|bacterioferritin	gnl\|CDD\|153099	cd00907, Bacterioferritin, Bacterioferritin, ferritin-like diiron-binding domain. Bacterioferritins, also known as cytochrome b1, are members of a broad superfamily of ferritin-like diiron-carboxylate proteins. Similar to ferritin in architecture, Bfr forms an oligomer of 24 subunits that assembles to form a hollow sphere with 432 symmetry. Up to 12 heme cofactor groups (iron protoporphyrin IX or coproporphyrin III) are bound between dimer pairs. The role of the heme is unknown, although it may be involved in mediating iron-core reduction and iron release. Each subunit is composed of a four-helix bundle which carries a diiron ferroxidase center; it is here that initial oxidation of ferrous iron by molecular oxygen occurs, facilitating the detoxification of iron, protection against dioxygen and radical products, and storage of ferric-hydroxyphosphate at the core. Some bacterioferritins are composed of two subunit types, one conferring heme-binding ability (alpha) and the other (beta) bestowing ferroxidase activity.	3.15748e-76
NZ_CP048830.1\|WP_000215708.1\|1609714_1610389_-\|HAD-family-hydrolase	gnl\|CDD\|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	2.4355e-26
NZ_CP048830.1\|WP_001227922.1\|1602667_1603723_+\|bifunctional-glycosyltransferase-family-2/GtrA-family-protein	gnl\|CDD\|133022	cd04179, DPM_DPG-synthase_like, DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.	1.16681e-34
NZ_CP048830.1\|WP_001239790.1\|1607518_1608748_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	2.43468e-56

>NZ_CP048830.1|WP_001190719.1|1612852_1613539_+|iron-containing-redox-enzyme-family-protein
MQSINTASTFRKTLEESVRNHPVLTFNLWLEKKEHKMEREDLLLWLRQEYFVSVDFVNWFLNTASICDSVEAKIVLVSNIWEELGEGNVENSHVFILKKFLSDMGEVVHEKHVLPETTSYLNLMQKITTSDFYSALGALGPANEYLLKLEYSRMFKSYLNLRERIILPEGKFFQVNLNADESHAEKLFRLIEVVADTEEKRNRVMEGSQLALDARLVFYEGLTTFQGL
>NZ_CP048830.1|WP_001038596.1|1611715_1612840_+|D-alanine--D-alanine-ligase
MNKMTPTVLVYADLHEFEGNFPEIYKQEWESKKSVDAILELLNEVGESIELVVTPNELLEKLKCYCDLDFSKRPVIFHLMEGFCSRNRESLIPAVAELFGFPHTGSDSYSQNVSLDKNLTRIFAQSIGVPVASGFWIRSKDVLFKELLQLECNSEIKKRFSFSKGNELNLKNFSFPAFIKPAGEGSSLGIGEKNIIYSFEELNTLLSEAPEIFFPYLLEEYLTGNEYTISVIGSATFGYKVSSAGRLILREDLKVEDVYGEKTKSKSIMPETLVFDCPKDLEVIIQQQSVLFCESLGTSGPARLDWKLDSLGNPFFLEMNLTPGLSPFYSTFPICYRHSLGDEKNLFQEILKIARLDFETDRFLYSKNKIRNLI
>NZ_CP048830.1|WP_001097889.1|1610472_1611723_+|KamA-family-radical-SAM-protein
MNTSHSFVQKSKGESFVNRSRLFSSFDWTDYKAQLQNRVKGFELERYFDLTESEKIGIENTIRLNVSATPYYISLADPEDPNCPIRKMILPREDECIFSPEESPDPLHEERLSPVKGLTHMYPDRVLLFTNHECSVYCRHCMRGRKVSDSKERMLTEDLEICFDYIKSHPEITDVVLSGGDPLNLSDSKIDWILERLEKIEHVKICRLGTRNPVTLPFRVTFDLCNIIESHNTDRLSIFCNTQFNHSKECTPEAKEAILKLLKAGVNVGNQCVLLKEVNDSGQTMLELHKKLLELRVRAYYMYDPELIPGSRGFRTPLAKGIEIIEFMRGKIGGMGIPQFVNDLPGGGGKITLTPNWYLGFYKPERIHVFKSALRGTYHFSPEPIDSKMEEFYPEISSEIWERVFSNSFGIYKSNE
>NZ_CP048830.1|WP_000215708.1|1609714_1610389_-|HAD-family-hydrolase
MTVFSVESLQALAFDVDGTLFSSEGIILEVYRDSILNFSKTSGIQIELPSRDRIMAEIGKPVKTIFFNLLPQLNEEQRDSISDSVLRFLCDRIKKGEGEFYPNVLETIEILAQKGYRILAASNGRKPYIQTILEVSGILPKFEPILVLDNKRIRTKAEILEEYIKLYHLKPNQILMIGDRLSDHEAARQNGCPFAFCSYGHAPEGEIPDFDLKLKNISDLNEVL
>NZ_CP048830.1|WP_001113397.1|1608861_1609671_-|hypothetical-protein
MPDSEKRKNIIFILTGIIFTLVLLDKSTGSGFSISNEGFNFNNIGKLTPKPYSSSKENFNHKEIMDQAEEEILEELLQNGDIQTSTDSSNSIEEDLNEDVPVLEPPIFSMDSTNEPDFPIPSEKGELSLFFLKFYGKGSKSHSRLVKVLRLSKGGDRVKLILNSLIAGPVSQEKEKGILNSIPQSLRYDDNYRIEKGILKLSLSSDLEKEAGPEILKDRIDQLIYSLMENLPIQGVQLKINGKFVRSLGGEGLPLPSLLTKNPRKIVVF
>NZ_CP048830.1|WP_001239790.1|1607518_1608748_-|GGDEF-domain-containing-protein
MRLSLGNNQKIKLLARRVFFNPFPDDYLRIYQPDVRRATVIYFFFCIGISFLSFLLPDGASLLGKENQILVYSRLTVLLLSAFFAFLLIKWRPFFRRRIERYSILSSGVIVFSILPYVFLDPGRMGLYFHFYTTLVVSGNILLWLTGTTVVIFNGLFYFSLVLCTSLTGNKNVLQHDFANVLIYLFTGIFGNLLINFWRVMDHRAKKKLQKAVSKLRDKNIQIEKISKVDELTGLYNRRYLIEQFELFLKRAQRYRFSLAMIILDMDYLKEINDSYGHLAGDLSLRTISDVMKQRVRATDICSRIGGDEFCILLDAIKKEDLVQLCENLRMEVAEKELSYRTQKGSPVKITVSIGACIFGPGEEFSFDDIYHSIDSALYESKKKGRNRVSFIEPIRYFPREYPGTTAAS
>NZ_CP048830.1|WP_000173137.1|1607130_1607535_+|hypothetical-protein
MTLKTKNLRGTKVIRILNCILVFLLAFGACTKQVKEHIHVDTGVTVEVLGVHKYKLIAIGGASSTSVEENDTFKMKNTSCTAAKSIAARKLEELEPEQKNRLFFMETVDTKYIDDGAYCEITYHYELPAPKKQQ
>NZ_CP048830.1|WP_000146501.1|1605199_1606303_+|dehypoxanthine-futalosine-cyclase
MASIFSSQPTDRILEKALDGNRISPEEALALYREGDHLKIMATARSLREKILPHHYASYTMFRVVNYTNYCNVECSFCSFMDEIGNGKGYVLSVEEILEKMDYAVGEGADQMFLQGGVYPDLSFDYYLNVISAVKKKYPHMHIRAFSPVEIINLEKITGLPLKEVLQILKQTGLDSVPGAGAEILTDRMRNIISPKKATTEEWVRAMETCHEVGLPGSANIVFGSEETQEEVIEHLNVVRNLQDRTGGFLSFIPWTFQPQTKRFKVRAVPTQEYLKVLGICRIFLDNILHIETSVMVLGKGVGQLALTSGADDISSVVIEENVLRSYGLKTEKEAVKFLKEGGFTPKRRDLLYNYDRYENELIVDFV
>NZ_CP048830.1|WP_002068674.1|1604772_1604934_+|hypothetical-protein
MIIIASIRSKKPIYFIKKSRLQGLSFASGIILERLDRLKIETNLLLQPHLKNT
>NZ_CP048830.1|WP_001227922.1|1602667_1603723_+|bifunctional-glycosyltransferase-family-2/GtrA-family-protein
MRKKSSFSIPIIIPAYNPDERLVQLVDELIQQGIVNIVVINDGSRESCTPIFKKLTKFKQCHLLHHATNLGKGRALKSAINYCMLTFPQMFGVVTADADGQHKVSDVIKVVQSLLKYPDQLILGSRKFDKDVPFRSLLGNKITSIVFAFLIGRRLIDTQTGLRGIPTKFLSTCLRLSGERYEYEMNMLISTKEHRLRIFEESIETLYLENNKSSHFNPLIDSARIYFLFFRFAFSSMLTSAIDFCVFTIVYLSVSNLLTSIIFSRTVAGTFNFFVNKRFVFRDPGGVAVEFVKYAFLVSGLGLLAFTAIRYLHSMHGWNVIVAKVFVETIFFLVSFAIQREFVFGNKSEEE
>NZ_CP048830.1|WP_001016365.1|1615274_1616387_-|acetylglutamate-kinase
MNHQEILLKLLEVTENTQDSFQFLKRFRSIEPEKFAVIYADSSTLMESAEALLYNLKLLHKLDLFPVVVLDKDGISYTNLFYRNQNKDDTPSILPGKLFRHPQDLAGAVRSALDEEKLPVFIAEEKGQVLFNFLTKLCSILRTKKLVHLYSRGGVYLKGNKISIFDVDSSIKPDPEDESILSICLELYKNVKDKDFEIAITSASSLLKELFTIKGSGTLLRRKNRIDFIEDPLTVSSEKLNLLIEKAFQKSLKKDFWNQKFAGILLESEFKGCALVKNTSFGTFLSKFAVDEIARGEGVGRDIWDELIYRFPILFWRARKENTISKWYMKVCDGMQKEGIWIYFWIGVQEIQVPNICSFLKNLPEDMSST
>NZ_CP048830.1|WP_000181059.1|1616402_1617653_-|N-6-DNA-methylase
MTNFKKPIPKKSLRLKSKRSDRKNFSNDPRQKQNPLKSEWDFSKPDSFEYHASCPDGLSGLLREEVIEAGLKIISENRGGIFFQGPAKALKEFILSTGIASGISISLKYWRVENPEDLYDQALQFPFEKILNSEHSLRIDSATKDSLKDSRYATYKLKDAIFDRFRSKGKEPPKISREEPDFLFYLRSHSDHAKLSLGLNTRPLQQRGHGRIGGEAPIREILASALIRYSGWDAKSQLYDPFCGSGTVVVEAALKLLYGGHTNYRSLASSLPFQKLFGQPNFKENLNLSSEIKIFASDLDPKTLGLARLNAKNAGVDHLIHFFESDAKISENEEKISEGFIVTNPPYGVRLGTKEEAKEAYLAWGKKLKDHFSGNVLAIVCGDTSLLGFLKLKKDKEQSLTIGKLKGKLVAYTLGR
>NZ_CP048830.1|WP_000677991.1|1617649_1618117_-|bacterioferritin
MKGNKEVLEILGEVLSAELTAINQYFIHAKMNKNWGFKKLADFMKRESIDEMKHADEVIDRILYLDGVPDLQRYMKINVGNNIEEILKVDLELEYAAVERFNRGIVIAVKNNDNGTRELFEKILISEEEHIDWIESQQEIIRQIGVENYLAQQIE
>NZ_CP048830.1|WP_000287368.1|1618263_1619382_+|thiolase-family-protein
MYSSAFIIDSELSHFGKTELDYHSLSYQTAIQLLERNSEFEPQFLIFAAMAPERYTGEVFVSARIKESLGLKNLFTIRTETASSSGASALHTAVYLLRSGAFQRGIIIATEVMSRLEREENNLLLGSVLSERQKGFAMSMAQGGGMIATRYLQQYGYDRRDLYLLSKKLHDNGLKNEKAHIKKNITEVEYFNSPVFTSPLCLYDISPLSDGSCAVLLSSEKTKSSRSLEIRGIGHGIGNLSNPPGDLSFSSSVTAFQGAYKEANLKPEQIQIAELHDAFTPFELIGAEDAKLFPRGSALRYVKEGKTHPEGQLPINASGGLKTRGHPVGVSGLAQIAELQSWMFKKERFQNGLALSIGGLGVNNFATILSKV
>NZ_CP048830.1|WP_001967602.1|1619395_1620427_+|glycosyltransferase-family-9-protein
MNEKILLIQTAFLGDLILTTSFFREVKKKYPNSYLTVVVNKGTESVLEANPYIDSLIPLDKKEFKKSIWKFFSFLRELRKENYTLCILPHFSFRSTLIGFASGAKERIGYETAGFSFLLTKKIPRPILGMHEVEKLFSLLYSKEEYSNIQKRPELYWKEESVFRIRELMKENRLESGNYVLLAPSSVWETKRMPASKFRVLGERIFKETGKKVVLIGSKADLDLCEEVGSGYAINFAGKTNLPELSFLVSKAALVISNDSSPIHFASAFNIPTLAVFGATVPDFGYTPLADLSFISEIHGLTCRPCGIHGGRTCPEGHFRCMKEQDTNKMFEVAVQLEQGNVK
>NZ_CP048830.1|WP_000205143.1|1620423_1621713_+|M24-family-metallopeptidase
MTSYIYSERIEKVQKRLKDGEVLIVFAASHLIRNRDVEYKFRQDSDYYYLTGIEESDGILILKNSYKSIFVLPKDKDKEIWTGIRIGKEKAKELLGLDESFDTNEWESKLDEILLNQHTLFHFFGKNLVRDSKLIEWIYSLNQRSREGKFGPKRIETPDFLHWMRMFKSAVEIEALRESARITALGHVRLMRESKPGMFEYELEAILESEYLKHGAWGGGYGHIVASGKNATILHYTSNNCQLKPGDLVLVDSGAEKGYYTADVTRNFPVGKKFSPEQKAVYEVVLRAQKEAVSNTKEGVEFASIHNQAVKTLVEGLKDLGLLEGSMDFILEQNTFKKYYMHRTSHYLGMDVHDVGSYYKDGASWSLQDGQVITIEPGLYFDPTDLTIPEKFRGIGIRIEDDVLVQGQNPVNLTSLIPKEIDEIESLKN
>NZ_CP048830.1|WP_000591544.1|1622064_1622628_+|DUF1564-family-protein
MIKKDQTSSQHIRNLRNEQKKSKFITDKKSISKRKRDSPSDLWIPRVKIPHLTRRISQFKSLKCTLHFLLKKNRNRLHSLFAQPEKEKTLYQETELELVRFSFRPNAADWAELRLVARYYGVSICNFFVMLLTFDENINKGSAKSFWKDSKNQKFQNSEILLIQLISSKRNTLFFSIITGLNTFHGF
>NZ_CP048830.1|WP_000583497.1|1623353_1623890_+|DUF1564-family-protein
MIIGTGNGMNIKKSKQPSKHLKLLKPNRFGKDRTEQKLQNFQKHLKKLGAPSDFNIPKELVSHLGKRIQKAGSLRLLLNQCIHKRPFLILVPKQTSRNKISYQEQKLELQRYSFRPFEDDWIELKRLSFLYGVSMCKMFVKLLLETDLYPESRYAENPILDKLEGDTGDPTLIQKTGS
>NZ_CP048830.1|WP_033108311.1|1624230_1626420_+|SpoIIE-family-protein-phosphatase
MKDNKLWLLKSFSIVSFFAKMFSNFYRMFFGVLSKHFLFYFLIIFSVSSESIQKIQSLDEIVSLDSTKEHGWEITLQKIDPVAFSDSYLKGQKNSNIQLEAYEAPGVYILPEESIQTAFIVKKFIAPKNWKGSGLAVRLGTLTDKDKTYLNGTLIGETGDMNSTLPQAYDKIRIYQIPNGLIRKDEVNILIIEVKKYFQKEIGIEQDKTAIGDSLLIQKELLETEYIKILLLMIYTTAGVYFLFLYLRRRADRENLYYGLFTILLVLYQFLRNQIKYDLGIEFIYMKKLEYMVLATLVPLFANFIRLYFKYPKTTILKVLDGLYVSFAIFYFFSNNVEHYNFINKNLVQYGWILYLGITLNHLIRRVIAKDRDAFLILIGVLITVFAAILDTLGARNVFVFPRLVGYSFLFFILSIATILANKFVRLNEEVEELNLGLEKKVEQRTEELRLSLEQVNRLKVQQDADYFLTSLLINPLSSNKNTSEVIKTEFYTKQKKSFEFKNRTYEIGGDILISGNVKLCGKKYVVFVNGDAMGKSIQGAGGALVLGTVFNTILTRSSISLYQNKQPEKWLEEAFLELQKIFESFDGSMYISIVLGLVEENTGLLYYINAEHPWTVLYRNGVACYIEEELTLRKIGIPENEEHLVIKNFQMLPGDTIVIGSDGRDDLLVGKEGNRVVNEDQNQFLKRVEEGNADLRKVYEEIIKFGVILDDLSLLKVTYNPEDSKTKE
>NZ_CP048830.1|WP_134795163.1|1626388_1626547_+|hypothetical-protein
MTQKIVKQKNKSISIFTQNDRIEFYHKSQSECKILLIPHNKILNLIVYTSIL

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Crispr_ID: NZ_CP048830_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048830_6

1691033-1691133

Orphan

Consensus_repeat	Method
GAGTTCCCACAATTTACACGAGATC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP048830_6

>merge|NZ_CP048830|6|1691033-1691133|CRISPRCasFinder
GAGTTCCCACAATTTACACGAGATCAAAAATCTTATGGGAGTTCCCACAATTTACACGAGATCAAAAATCTTATGGGAGTTCCCACAATTTACACAAGATC

>NZ_CP048830|6|6|1691033-1691133|CRISPRCasFinder
GAGTTCCCACAATTTACACGAGATC	AAAAATCTTATGGGAGTTCCCACAATTTACACGAGATCAAAAATCTTATGG
GAGTTCCCACAATTTACACAAGATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048830.1\|WP_000137385.1\|1689732_1689996_+\|flagellar-biosynthesis-protein-FliQ	unknown	unknown	gnl\|CDD\|235567
NZ_CP048830.1\|WP_000371641.1\|1696206_1697121_+\|MinD/ParA-family-protein	unknown	unknown	gnl\|CDD\|349758
NZ_CP048830.1\|WP_000938817.1\|1683535_1685761_+\|phosphatidylserine-decarboxylase	unknown	unknown	gnl\|CDD\|234591
NZ_CP048830.1\|WP_001202901.1\|1682606_1683473_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000039671.1\|1697728_1698529_+\|RNA-polymerase-sigma-factor-WhiG	unknown	unknown	gnl\|CDD\|235770
NZ_CP048830.1\|WP_000455609.1\|1690002_1690782_+\|flagellar-biosynthetic-protein-FliR	unknown	unknown	gnl\|CDD\|376520
NZ_CP048830.1\|WP_001053201.1\|1697124_1697601_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_001162079.1\|1681061_1682258_+\|sterol-desaturase-family-protein	unknown	unknown	gnl\|CDD\|225546
NZ_CP048830.1\|WP_000057945.1\|1686123_1686450_+\|DUF971-domain-containing-protein	unknown	unknown	gnl\|CDD\|377616
NZ_CP048830.1\|WP_000393533.1\|1694898_1696179_+\|flagellar-biosynthesis-protein-FlhF	unknown	unknown	gnl\|CDD\|183703
NZ_CP048830.1\|WP_000418455.1\|1700947_1702000_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_001239630.1\|1700548_1700902_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000503780.1\|1687017_1688082_+\|flagellar-motor-switch-protein-FliN	unknown	unknown	gnl\|CDD\|236154
NZ_CP048830.1\|WP_080010664.1\|1702277_1702859_+\|guanylate-kinase	unknown	unknown	gnl\|CDD\|173199
NZ_CP048830.1\|WP_000167663.1\|1680269_1681055_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223377
NZ_CP048830.1\|WP_000535110.1\|1698554_1700540_+\|FapA-family-protein	unknown	unknown	gnl\|CDD\|377177
NZ_CP048830.1\|WP_000412863.1\|1692728_1694846_+\|flagellar-biosynthesis-protein-FlhA	unknown	unknown	gnl\|CDD\|376386
NZ_CP048830.1\|WP_000077420.1\|1701999_1702281_+\|DUF370-domain-containing-protein	unknown	unknown	gnl\|CDD\|179823
NZ_CP048830.1\|WP_000783972.1\|1688932_1689736_+\|flagellar-type-III-secretion-system-pore-protein-FliP	unknown	unknown	gnl\|CDD\|235566
NZ_CP048830.1\|WP_001211503.1\|1688078_1688900_+\|flagellar-biosynthetic-protein-FliO	unknown	unknown	gnl\|CDD\|274610

Protein	Function_ID	Function_description	E-value
NZ_CP048830.1\|WP_000137385.1\|1689732_1689996_+\|flagellar-biosynthesis-protein-FliQ	gnl\|CDD\|235567	PRK05700, fliQ, flagellar type III secretion system protein FliQ.	3.39933e-22
NZ_CP048830.1\|WP_000371641.1\|1696206_1697121_+\|MinD/ParA-family-protein	gnl\|CDD\|349758	cd02038, FlhG-like, MinD-like ATPase FlhG. FlhG is a member of the SIMIBI superfamily. FlhG (also known as YlxH) is a major determinant for a variety of flagellation patterns. It effects location and number of bacterial flagella during C-ring assembly.	6.04694e-100
NZ_CP048830.1\|WP_000938817.1\|1683535_1685761_+\|phosphatidylserine-decarboxylase	gnl\|CDD\|234591	PRK00044, psd, phosphatidylserine decarboxylase; Reviewed.	1.01837e-78
NZ_CP048830.1\|WP_000039671.1\|1697728_1698529_+\|RNA-polymerase-sigma-factor-WhiG	gnl\|CDD\|235770	PRK06288, PRK06288, RNA polymerase sigma factor WhiG; Reviewed.	1.34169e-161
NZ_CP048830.1\|WP_000455609.1\|1690002_1690782_+\|flagellar-biosynthetic-protein-FliR	gnl\|CDD\|376520	pfam01311, Bac_export_1, Bacterial export proteins, family 1. This family includes the following members; FliR, MopE, SsaT, YopT, Hrp, HrcT and SpaR All of these members export proteins, that do not possess signal peptides, through the membrane. Although the proteins that these exporters move may be different, the exporters are thought to function in similar ways.	3.23001e-47
NZ_CP048830.1\|WP_001162079.1\|1681061_1682258_+\|sterol-desaturase-family-protein	gnl\|CDD\|225546	COG3000, ERG3, Sterol desaturase [Lipid metabolism].	1.25786e-25
NZ_CP048830.1\|WP_000057945.1\|1686123_1686450_+\|DUF971-domain-containing-protein	gnl\|CDD\|377616	pfam06155, DUF971, Protein of unknown function (DUF971). This family consists of several short bacterial proteins and one sequence from Oryza sativa. The function of this family is unknown.	1.93082e-27
NZ_CP048830.1\|WP_000393533.1\|1694898_1696179_+\|flagellar-biosynthesis-protein-FlhF	gnl\|CDD\|183703	PRK12724, PRK12724, flagellar biosynthesis regulator FlhF; Provisional.	0
NZ_CP048830.1\|WP_000503780.1\|1687017_1688082_+\|flagellar-motor-switch-protein-FliN	gnl\|CDD\|236154	PRK08119, PRK08119, flagellar motor switch protein; Validated.	3.82163e-67
NZ_CP048830.1\|WP_080010664.1\|1702277_1702859_+\|guanylate-kinase	gnl\|CDD\|173199	PRK14737, gmk, guanylate kinase; Provisional.	3.18662e-107
NZ_CP048830.1\|WP_000167663.1\|1680269_1681055_+\|SDR-family-oxidoreductase	gnl\|CDD\|223377	COG0300, DltE, Short-chain dehydrogenases of various substrate specificities [General function prediction only].	1.13871e-96
NZ_CP048830.1\|WP_000535110.1\|1698554_1700540_+\|FapA-family-protein	gnl\|CDD\|377177	pfam03961, FapA, Flagellar Assembly Protein A. Members of this family include FapA (flagellar assembly protein A), found in Vibrio vulnificus. The synthesis of flagella allows bacteria to respond to chemotaxis by facilitating motility. Studies examining the role of FapA show that the loss or delocalization of FapA results in a complete failure of the flagellar biosynthesis and motility in response to glucose mediated chemotaxis. The polar localization of FapA is required for flagellar synthesis, and dephosphorylated EIIAGlc (Glucose-permease IIA component) inhibited the polar localization of FapA through direct interaction.	1.04939e-140
NZ_CP048830.1\|WP_000412863.1\|1692728_1694846_+\|flagellar-biosynthesis-protein-FlhA	gnl\|CDD\|376386	pfam00771, FHIPEP, FHIPEP family.	0
NZ_CP048830.1\|WP_000077420.1\|1701999_1702281_+\|DUF370-domain-containing-protein	gnl\|CDD\|179823	PRK04323, PRK04323, hypothetical protein; Provisional.	3.36055e-36
NZ_CP048830.1\|WP_000783972.1\|1688932_1689736_+\|flagellar-type-III-secretion-system-pore-protein-FliP	gnl\|CDD\|235566	PRK05699, fliP, flagellar biosynthesis protein FliP; Reviewed.	1.17637e-106
NZ_CP048830.1\|WP_001211503.1\|1688078_1688900_+\|flagellar-biosynthetic-protein-FliO	gnl\|CDD\|274610	TIGR03500, FliO_TIGR, flagellar biosynthetic protein FliO. This short protein found in flagellar biosynthesis operons contains a highly hydrophobic N-terminal sequence followed generally by two basic amino acids. This region is reminiscent of but distinct from the twin-arginine translocation signal sequence. Some instances of this gene have been names "FliZ" but phylogenetic tree building supports a single FliO family.	1.50403e-15

>NZ_CP048830.1|WP_000455609.1|1690002_1690782_+|flagellar-biosynthetic-protein-FliR
MEYFINHFQVFLLILSRLMGLLSVAPVFSYPSIGVPQKMIFSFLVSVILFPVIAGFLPPVPGDMGSYGLVVIAEALIGILLGFLISLIFAAFQMAGEFFNVQLGFGYAEILDPVTQTSLPVISTLKNLLGMLLFLTLGAYRIMFESLAYSFEKIQVLRFVPEIQNGIYKAMEDAVGAMFFVAFRLSLPVLGIILLVTVSEALMGKAAPQLNILQLSFPIKVTIGLIVMIFITPYLVSQMGAAFDLSFDKVNLMLQEWPK
>NZ_CP048830.1|WP_000137385.1|1689732_1689996_+|flagellar-biosynthesis-protein-FliQ
MTELDVMTLIRDSLYITLKISSPILFTALVVGLIVGILQTTTSIQEPTIAFVPKLLAIFIVIVIFSSWMIQTMTDYTRNLFLMIEKF
>NZ_CP048830.1|WP_000783972.1|1688932_1689736_+|flagellar-type-III-secretion-system-pore-protein-FliP
MKMRHKKFIKSITWIFLLLAGLSLGSTFFTLEAQSAGTRIPIPNLNINVNEAKSPRETSLSLMVLFLVTILSLAPAIVMSLTSFTKIVIVLDFVRRALSIQNLPPNQVMMGLALFMTFFIMAPTLNTVNEKALGPYLEGKIDTNAFFEKGMIPIREFMMRQIGTSGAKDVALFLKIGKVEKVESFDDVPSYVLIPAFMLSEIKKAFWIGIVIFIPFIVIDLVVASALLSMGLMMLPPVMVSLPFKLILFVLVDGWNLIVYELVRSYK
>NZ_CP048830.1|WP_001211503.1|1688078_1688900_+|flagellar-biosynthetic-protein-FliO
MRFLKTSQSNGKKTISVLSLLIIFNFTVISLSAQSERELMDEALKKELGDFSQKKNQETNSGGKKADGSTTNSSTEIKSAQNGTSQSNSSEIQQESNPVEERYRPKDEGPGIAGTLLRVVFILGLLCAALYYILKYVSKNREGKLPVRGEMSVLSSLIIGPNKQLQIVEVSDRLLVLGVADNGINLITEISDPEVKHRILQKKETFQPPEDGFLVTVLEQIKDLNSRISGNTEGPPDSGGGAAREEKRKQARKKLEELKEKTSSLEGGLFDLR
>NZ_CP048830.1|WP_000503780.1|1687017_1688082_+|flagellar-motor-switch-protein-FliN
MGEGSLSQEEIDALLAGASDSFDPGTVAPAATQKEVPGMSPVDRDILSDLLASCFQVAGNTLGAVLSRSSAFLNPNVETKTRKDIESELKSGSFLLYSTLSGSVNGRVVLAMSAENAVKISNSMMGGFDSGELDEAQMQTLRDSLTPVMGALISQISTKTGGGVNGSPSETRNVTSPAALVLPDGETLIRVFFNLTIENIPSFRVQFLLSLSTASDLLNLYRRSGSAGGDMSGMGMGGMGGMGMAPGSMSVKSVAFPNLGTASGASNTPNLNLLMDVQMSVTVELGRTKMYIKDILGLGEGSIIELDKLAGEPVDLLVNGKLIAKGEVVVIDENFGVRVTDIVSPIDRIKPEGK
>NZ_CP048830.1|WP_000057945.1|1686123_1686450_+|DUF971-domain-containing-protein
MAQLSLKATTPDQIDFDENHLKITWKDGVTSIFDLLDLRKRCPCVVCKGGHGGKIGTTTGAIQSIRLCSVNKVGRYAINLIWSDNHQTGIYSYDSLRMFADGLGGELS
>NZ_CP048830.1|WP_000938817.1|1683535_1685761_+|phosphatidylserine-decarboxylase
MLQFHFFQFLDWDLLKFFFYFLSFIGVFLTIRLRFPQLRFLFLAIKIFSGNMDYKGSRGRLVHSQAFFSGTASSLLPGAVIGSALALMIGGPGVLFWIWISSFFIMPLRFVSSTLAIRFRTKTDSGRYLSGPMYFIESALKARWLAVGFAAVGLLTVLVMGGVVPMLYVTHIANRVFEINGMTVPFLLSVILVFIVLGGVRRVGKVSAYLAPIGILLFFLSYFFLFKGSLMNFKDFIWLSFKEAFQPGAAITGGGFALARVYSMASGIFFVSTETGIGKSAGLSGVVRTDYPAKQGLVSMLATFFEGFIISTLVVYALSSYGAFKMEEQLVFLNALFQGNTNPINAAFFVSFLLFGVVSITGWFYTGEQKALYVFGEKFANFFRMLFLFTILAVAYLYVKNGEQILFEAFGLGYSLSIITAVPVLISLVLLEKIARTELKRFLTESGARYEVLKDFYILILSVVPKNLLSRLFGLLASSRLPRFILIPILKAFARAYKINVDEAELEIQEYNSLNEFFTRALKAESRIIDSADDEMVSPVDAKITGYGDINQRIIIQAKGVDYNLKELLGGSKYLEDFTNGKYITFYLSPQDYHRIHSPAYGKILGYYYEPGKLFPVNELAVFGIRGLFPKNERLITYLQTEYGKVAVIKVGASNVGRIRVTYDNKIVTNTLIRTARTVEYKEVSIMIGKGAELGRFEMGSTVILLMEKDTFQFNSLTVNEKITYGTTIGKFKKKKCKLPK
>NZ_CP048830.1|WP_001202901.1|1682606_1683473_-|hypothetical-protein
MRATSKIFGILLSVLFFLFCPYSILKAQSSKIKTHSVKPALEIPNPEEENWELGLRAGIGYKGEDRLNSFLRGFTNTYDPGVASKTELDPPKQTTQVELFIRKRIASESQIGFIGGYREWQKFGLKQFSSEPFYTDLKFKISNPYALLMYWHEWNYKRWIFQGGLGAGMSQVYWDSEGYATSGKETFRQEGLLSGTGIEFRLEGAVSRRITESASIQLGIAFSWINIPSLSGTFNGESASFYLRENGSITPLTESDNQTSMLVTNQFSRKLEFQVLTTTLFFGIAQKF
>NZ_CP048830.1|WP_001162079.1|1681061_1682258_+|sterol-desaturase-family-protein
MQGSVLDLAVPFFLILIGFEVLYSKIVGKKVYRWNDTVADLSTGILFSLTGVCVTIFSLWIYEKFRIFCSLQTLFGVPEIPLGIPIWPDPVGWHFDFKSLVGWIFVFLAVDFVYYWFHRATHEINFLWACHVTHHSSEEFNLSVALRQSSFQRIFEYMFNLSIAFCGVPWQAFLLAHGILKIYQFWVHTRLVGKLGFLEEILITPSHHRVHHGRDPKYIDKNHGGILVFWDRIFGSFAREEEEPIYGLTKPVTTFDPVYTNVHVYEEIFSLVQKTNNWKERILLFLKPPGWRPESLGSSVYAEEVDRNRYIKYDPIVSKQRMVLGFLEFLVLTVFSLLLLKYFKSGIFELWKIFPVIVFFFYGFRLTGFVLDGYTIGKARIILFLLVGMILYWILFFV
>NZ_CP048830.1|WP_000167663.1|1680269_1681055_+|SDR-family-oxidoreductase
MTKTAIITGGTVGIGYELSKLIAADGYDLILVARNEKTLKKVKKEIESSNKVKVDILSLDLADPKSPKKIFDFAKKTKAVVEVLVNNAGFGTNGKFDRMDLKEELQMVQVNVASLVELTHLFLQGMVERKNGKILNVASIAGFQPGPNMANYYATKAYVLSFSEAVYEDVKKDGVTVTALCPGPTKTEFFERAEITKSKLLDNPMAPIMEAKEVAEIGYDALKKGKSVVIAGALNKILAQSVRITPRFVTRKITKFFNQNG
>NZ_CP048830.1|WP_000412863.1|1692728_1694846_+|flagellar-biosynthesis-protein-FlhA
MEKKWWNQSDVILGIGAVAVVAMLVIPLPGFILDILIIVSLAIGLLVLLTSLSVNEPADFSIFPSLLLITTLYRLALNVSTTRQILSKGPAMNSHVIDAFGSFIIGSESGLSKYVVGFIIFIILVLVQILVITKGATRISEVAARFTLDALPGKQMAIDMELSSGNINEEEAKKRRKRIEAEVDFYGSMDGASKFVQGDVRAGLIITAINLLGGVIIGSSIRGESFTQAIETYGKFTIGDGLVSQIPALLTTVATGIIVTRSGSESDLATQFKSQLFSNSKVLYVVAGSLGFAAFIPGLPFIPLVLLSAGIAYLGYSLEQTVKEQLESIEKKEKESGQDRKPKDFYEELRTDPIEIEVGYHLIPLVDVSQGGALLDQISNLRKKFAQDNGVVIPPVRILDNLDLNPDTYSIKINGTEVGASTVKPDKLMALNTSPGSAESIAGEDFLEPSFGQRAKWISAEDKSDAEAKGYTVVDASTVVVTHLKELLATHASTLLGREEVKKLLDHYKTSYPTLIGELDADKPGNLGIIQQVLQNLLREGLGIRNLVPILESIANNLSKYQNPYILTELVRQSISRTVVRDYLSMDGKLRVITLESRILDRLNKSITQDRIENRDVLSLAPDFYRRLIDSVAELYRNFRTEGKFPIFVVNREVRLPFSYMLAKEFPPRNFGVLAYEEIHSSVDSVIEAELKLPQAQTAGISEET
>NZ_CP048830.1|WP_000393533.1|1694898_1696179_+|flagellar-biosynthesis-protein-FlhF
MEFAKIRGKSYQDCLMEMKMKYGSEATVISQTVVTEGGVMGTGLLAKKMIEIQIGIPEKQASREKIERKLQDLKDLLKQKSYASPERKKTLQTLKPLSKTLEEKEIAVEEEIEEITTEPDRVGLSFEKELLDKNSFLRRETSTVRKDSPLIRLGEKLVREGMSQSYVEEIISKVEERLSPLDQGRNHAVLERTIEILKERVSVDSDLFRGTGKNQRKVIFFVGPTGSGKTTSVAKLAAKYFLHRGKSVSLYTTDNYRIAAIEQLKRYADTMGMPFYPVKDIKKFKETLARDGSELILIDTAGYSHRNLEQLERMNSLLSCFGEKDSVENLLVLSSTSSYHHTSTVLKAYESLNYRRILLTKLDEADFLGGFLELADTYSKSFTYYSVGQEVPFDILSAEKNLMAECVVTPEKIAELRGEVFTVAGD
>NZ_CP048830.1|WP_000371641.1|1696206_1697121_+|MinD/ParA-family-protein
MDQAAHLRKLTEGNTSLKVLSSRKPTTKIVAIASGKGGVGKSTISVNLAISMARVGQKVLVFDGDLGLANVNVILGIIPKYNLYHVVKGHKSLKDIVIQTPEGVDIIAGASGYSQLANLNDTQRNSLIKGFSELDNYDIMIIDTGAGISSNVIGLTLPADDVIVITTPEPTAITDSYGLIKAIVSQSRDKNLKMVVNRVRSAIEGKKVADRVIDISGQFLEVKVENLGFIFQDEEVEKSIREQKPYIINSPKSKAAACLNRITYSLLNQDIEPLEDSGIGGFFKKFFNFMDVRDKEFDKNDEEE
>NZ_CP048830.1|WP_001053201.1|1697124_1697601_+|hypothetical-protein
MNLQILFIGVFVIVAFVISALCGFLIGNSFGHILLVTFLSMIAFAVLGFGIHAVLETKVPEFLDFLSNIGGEYIPPTQATDSENVVRGRDYTSNASDTDLAEGSSSNSEVFASSAPKRQKDGNFGDHIMVENIAIKNEPKLMAEAIRTMLARDDMGEK
>NZ_CP048830.1|WP_000039671.1|1697728_1698529_+|RNA-polymerase-sigma-factor-WhiG
MSKKYEKYNQQDETELWKSYRETKDQDIRSYLVEKYSPLVKHVAGRIAIGMPQNVEFDDLVSYGVFGLLDAIEKFDPERLIKFKTYAMTRIRGSIFDELRSIDWIPRSIRQKAKQLEQIIGMLENKEGQQVDDDAIAKELGISMEEYNSLLTKISGTSLVSLNDIWFLGDENDEVSFMETLESPMNMNPDTIIEKEEIKNVIVEAIKTLPEKEKKVIVLYYYEDLTLKEIGEVLEVTESRISQLHTRAVSRLRSKLGKVKSVISRK
>NZ_CP048830.1|WP_000535110.1|1698554_1700540_+|FapA-family-protein
MGSLIPFLQDQSKELDRIQNEQVEVYGDTLENSLRLAAKHLKKQVHELDYVVLKRGKKKLFGHEPWHIRVSILPEDNFLDELTELDQKLTGGSGKLVSKDLKDLIQPKDKNGKALVQILRNGVYLTTFAPLGDGHPVDLDEVFKKLSLKGVSGEDGKLVRKIVKEAKGEPILISQQKPRPGMEAKLILDISPDKMKAKVTILPPRPGGRDFEVRDVVNHLKNAGVKYGFKEEEIQRKLEEEFYNQPFIGAEGDYPINGKNAQIIYHVRTSKNISFREDESGRVDFKDLDLIENVVVGQLLAEKIPAEKGKYGRTLFNELLPAKDGADTDLKQGKGTILSEDRSKLTAEVNGQVVYATGRLSVETVYRVNGDVGIKTGNVTFLGSIVITGNVEDNYSVKAAGNIEIYGTVQKARVEADGDIIIRQGISGREEAHVESTGGNVIAKFIQSATVITEKDVMVQEGVLHSFVSAGGKILCNGKRGQIVGGTVRASELIAARSIGSSANPATELVVGIDPKVLKQIADYEAKMHESQAKHEQVFKSLKTLQARKESDPASFTEEHENQLSKMQKAVDKLDSRIKEFETEINNLKNYMEEKSSHGKISIEKVLYGGVTMRIRNSDFKTRNEIKNKTFVEENGMIRQVPYEDPEPDKKDWRKKRNRGN
>NZ_CP048830.1|WP_001239630.1|1700548_1700902_+|hypothetical-protein
MRLSDTFLGYGQAPDMIRKQQVENPFTMPHMISETSRVVKEYNDTRKYAVELYTDVFSLSPESRERMALARNQKIDQIKDRLKTYKSASDDKSYTYSSNGQKTSNVPSNRGKIEFFA
>NZ_CP048830.1|WP_000418455.1|1700947_1702000_+|hypothetical-protein
MELFAVFAINAVVSVVLYYTITSKVTERIRTHMLGKINEEIRDFIDELETESLRQVDLMGARILTFKEITSKAEELVKRIEQSTSPDILEKIQIVDKDSVINNENKRSENLYPLKNGNHTGVSDSVQQGVGHIYKENLDLTREDAENFSNLQKVSNSKIHTSYIQKLETTSKVVKKEVVSQNKPEILPQGSTSNLVLETIGKGIRKFFGIQEIKTIRSENETSGNDFFPGTRNSTLDISLDENPFAPISESKLNETSSLVFKDNLKPKEADFGRILQENIVGYQPIKPDSTKISAEAALLEIGDDSTKIEKVVFLLKRKYTHEEISEVLDLALGEVDIIERFRLDRNRRF
>NZ_CP048830.1|WP_000077420.1|1701999_1702281_+|DUF370-domain-containing-protein
MSQFSVLNVGFGNIVLVSKIVSIIHSDSASAKRIRNEAKSNNSLIDATQGKKTRSIIVTDSNHLILSNLRVESLTKRIESRDNSIASEEEDLD
>NZ_CP048830.1|WP_080010664.1|1702277_1702859_+|guanylate-kinase
MNSPKLFVLSSVAGGGKSTLIQKIREKHPEILFSVSCTTRAPRPGDKEGITYFFLTKEEFEKGISESAFLEWALVHDQYYGTPLKFIEGAFQKGSSVIMDIDVQGAKIIKEKLPDKIVTIFILPPNEKEWEKRLRGRGTDSEENILKRIQNGKLELERQNEFDYKIVNDNLDRALAELENIILKSESKSTTEK

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Crispr_ID: NZ_CP048830_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048830_7

2011975-2012065

Orphan

Consensus_repeat	Method
TAGGAAGTGATGCATTGAGTTCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP048830_7

>merge|NZ_CP048830|7|2011975-2012065|CRISPRCasFinder
TAGGAAGTGATGCATTGAGTTCAGGGAGTGAGACGCTTTAGTTCCTTCAAACGACCTGCAGCGACCCGTAGGAAGTGATGCATTGAGTTCA

>NZ_CP048830|7|7|2011975-2012065|CRISPRCasFinder
TAGGAAGTGATGCATTGAGTTCA	GGGAGTGAGACGCTTTAGTTCCTTCAAACGACCTGCAGCGACCCG
TAGGAAGTGATGCATTGAGTTCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048830.1\|WP_001053850.1\|2013434_2014175_+\|rRNA-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|224108
NZ_CP048830.1\|WP_000454163.1\|2006685_2007996_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|274940
NZ_CP048830.1\|WP_000424879.1\|2018231_2018876_-\|fructose-6-phosphate-aldolase	unknown	unknown	gnl\|CDD\|234947
NZ_CP048830.1\|WP_001009415.1\|2014171_2015590_+\|MBOAT-family-protein	unknown	unknown	gnl\|CDD\|224610
NZ_CP048830.1\|WP_000394962.1\|2019817_2020444_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000433870.1\|2012142_2012442_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_001217817.1\|2019055_2019787_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000194186.1\|2001593_2002262_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187586
NZ_CP048830.1\|WP_000659012.1\|2000244_2001150_-\|UDP-3-O-acyl-N-acetylglucosamine-deacetylase	unknown	unknown	gnl\|CDD\|237294
NZ_CP048830.1\|WP_001068719.1\|2012429_2013335_-\|lipoyl-synthase	unknown	unknown	gnl\|CDD\|235493
NZ_CP048830.1\|WP_154213693.1\|2006299_2006566_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000486431.1\|2008236_2009571_+\|glucose-dehydrogenase	unknown	unknown	gnl\|CDD\|369642
NZ_CP048830.1\|WP_001019283.1\|2003025_2003700_+\|TIGR00266-family-protein	unknown	unknown	gnl\|CDD\|376704
NZ_CP048830.1\|WP_000714033.1\|2009670_2010837_+\|lipoprotein-LipL45	unknown	unknown	gnl\|CDD\|380173
NZ_CP048830.1\|WP_000021495.1\|2017801_2018077_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_001105364.1\|2002344_2003010_+\|TIGR00266-family-protein	unknown	unknown	gnl\|CDD\|376704
NZ_CP048830.1\|WP_000725565.1\|2015603_2016650_+\|DUF1574-domain-containing-protein	unknown	unknown	gnl\|CDD\|369442
NZ_CP048830.1\|WP_001113029.1\|2004718_2005816_-\|DNA-alkylation-repair-protein	unknown	unknown	gnl\|CDD\|226785
NZ_CP048830.1\|WP_000614725.1\|2020446_2021982_-\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234854
NZ_CP048830.1\|WP_000873009.1\|2003712_2004393_+\|TIGR00266-family-protein	unknown	unknown	gnl\|CDD\|376704

Protein	Function_ID	Function_description	E-value
NZ_CP048830.1\|WP_001053850.1\|2013434_2014175_+\|rRNA-pseudouridine-synthase	gnl\|CDD\|224108	COG1187, RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis].	2.16615e-73
NZ_CP048830.1\|WP_000454163.1\|2006685_2007996_-\|radical-SAM-protein	gnl\|CDD\|274940	TIGR04043, hypothetical_protein_WH5701_02349, radical SAM protein, MSMEG_0568 family. Members of this protein family are radical SAM proteins related to MSMEG_0568 from Mycobacterium smegmatis. Members occur within 8-gene operons in species as diverse as M. smegmatis, Rhizobium leguminosarum, Synechococcus elongatus, and Sorangium cellulosum. The function of the operon is unknown, but similarity of MSMEG_0568 to some cofactor biosynthesis radical SAM proteins suggests a similar biosynthetic function. [Unknown function, Enzymes of unknown specificity].	0.000343124
NZ_CP048830.1\|WP_000424879.1\|2018231_2018876_-\|fructose-6-phosphate-aldolase	gnl\|CDD\|234947	PRK01362, PRK01362, fructose-6-phosphate aldolase.	1.45744e-146
NZ_CP048830.1\|WP_001009415.1\|2014171_2015590_+\|MBOAT-family-protein	gnl\|CDD\|224610	COG1696, DltB, Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane].	4.0587e-54
NZ_CP048830.1\|WP_000614725.1\|2020446_2021982_-\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	gnl\|CDD\|234854	PRK00881, purH, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional.	0
NZ_CP048830.1\|WP_000194186.1\|2001593_2002262_-\|SDR-family-oxidoreductase	gnl\|CDD\|187586	cd05325, carb_red_sniffer_like_SDR_c, carbonyl reductase sniffer-like, classical (c) SDRs. Sniffer is an NADPH-dependent carbonyl reductase of the classical SDR family. Studies in Drosophila melanogaster implicate Sniffer in the prevention of neurodegeneration due to aging and oxidative-stress. This subgroup also includes Rhodococcus sp. AD45 IsoH, which is an NAD-dependent 1-hydroxy-2-glutathionyl-2-methyl-3-butene dehydrogenase involved in isoprene metabolism, Aspergillus nidulans StcE encoded by a gene which is part of a proposed sterigmatocystin biosynthesis gene cluster, Bacillus circulans SANK 72073 BtrF encoded by a gene found in the butirosin biosynthesis gene cluster, and Aspergillus parasiticus nor-1 involved in the biosynthesis of aflatoxins. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.12393e-82
NZ_CP048830.1\|WP_000659012.1\|2000244_2001150_-\|UDP-3-O-acyl-N-acetylglucosamine-deacetylase	gnl\|CDD\|237294	PRK13186, lpxC, UDP-3-O-acyl-N-acetylglucosamine deacetylase.	3.51777e-139
NZ_CP048830.1\|WP_001068719.1\|2012429_2013335_-\|lipoyl-synthase	gnl\|CDD\|235493	PRK05481, PRK05481, lipoyl synthase; Provisional.	9.60769e-179
NZ_CP048830.1\|WP_000486431.1\|2008236_2009571_+\|glucose-dehydrogenase	gnl\|CDD\|369642	pfam07995, GSDH, Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.	2.13565e-38
NZ_CP048830.1\|WP_001019283.1\|2003025_2003700_+\|TIGR00266-family-protein	gnl\|CDD\|376704	pfam01987, AIM24, Mitochondrial biogenesis AIM24. In eukaryotes, this domain is involved in mitochondrial biogenesis. Its function in prokaryotes in unknown.	3.31316e-76
NZ_CP048830.1\|WP_000714033.1\|2009670_2010837_+\|lipoprotein-LipL45	gnl\|CDD\|380173	NF033165, lipo_LipL45, lipoprotein LipL45. Members of this family are lipoprotein LipL45, as described in Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 but found broadly in the genus Leptospira. Close homologs that are not lipoproteins by sequence are likely defective in their reported coding region.	0
NZ_CP048830.1\|WP_001105364.1\|2002344_2003010_+\|TIGR00266-family-protein	gnl\|CDD\|376704	pfam01987, AIM24, Mitochondrial biogenesis AIM24. In eukaryotes, this domain is involved in mitochondrial biogenesis. Its function in prokaryotes in unknown.	1.83686e-76
NZ_CP048830.1\|WP_000725565.1\|2015603_2016650_+\|DUF1574-domain-containing-protein	gnl\|CDD\|369442	pfam07611, DUF1574, Protein of unknown function (DUF1574). A family of hypothetical proteins in Leptospira interrogans.	1.40477e-138
NZ_CP048830.1\|WP_001113029.1\|2004718_2005816_-\|DNA-alkylation-repair-protein	gnl\|CDD\|226785	COG4335, COG4335, DNA alkylation repair enzyme [DNA replication, recombination, and repair].	5.81772e-47
NZ_CP048830.1\|WP_000873009.1\|2003712_2004393_+\|TIGR00266-family-protein	gnl\|CDD\|376704	pfam01987, AIM24, Mitochondrial biogenesis AIM24. In eukaryotes, this domain is involved in mitochondrial biogenesis. Its function in prokaryotes in unknown.	5.98011e-74

>NZ_CP048830.1|WP_000714033.1|2009670_2010837_+|lipoprotein-LipL45
MKKFLIVFSSVLTTGLLVFNACKKPTESSKAAATKGNSPSAVVVFSVGEAKILHADLTEEKAALGASLKTGDKVSTKQKSKVDIQFADGSAIRISENSVIDFDALSINSHGNSDTRLALVSGKVFAKVNKASKEDQFSVVTPTAIAGVRGTSFIVDRSKSDKAVVKVLEGAVAVAPRVVVLEGLSDEEIAKDEDLKKIQQTVASSEIVLEKNQASVVKADEKSLDVKDTSKISEKNITGVVKKLDNSGISKKEEEEIRTIVTVDKDTTEKMVRLNEESSGKVDEQKAAVLEAERKKLESEVAARQEEEAKKFKQVLISAPKELKSSKDIVNYYERIEKIIMMDGSSMIGAIVDQQGSTMIVHTEQGIKKINQADVQEVIYDFQTKAKF
>NZ_CP048830.1|WP_000486431.1|2008236_2009571_+|glucose-dehydrogenase
MFQIRDICSIFLRIYFYRFCRLEWILLLVSKLFSLFCNLENFITRFIRLYSCIFLFRVLLTIGVVLILDSPLTADKKQPRRNVIKTKVESIGYVSVADGFQEPTDIQFFPGDPKRMIILEKRGKLIEVDLTTKVKTLRADFTGQIETRSEEGLLGLAFSPDFQTDSKFFVNVIVKEGGKDYSKILEFEWKEHLVQKIEHSKRMILKLEQPYSNHNGGQLAFGPDRKLYIGFGDGGGANDPYKNGQNPGTFLGKLLRILPNPHAAGAAYKVPEDNPFVHHPGFLPEIWSYGFRNPWRFSFDKLTGELYVADVGQNEFEEIDLIQKGGNYGWNIREGFHCFKKNPGCVDNFLIDPIHEYSREEGQSITGGYVYRGKEIPKLVGSYLYGDFVTGKIWALKQKNGKKISNELVIQVPFQISTFGQDISGEVYFTDFGSGNIFRIAKKN
>NZ_CP048830.1|WP_000454163.1|2006685_2007996_-|radical-SAM-protein
MEVTNSVRQISTISLLEEMEKKYKSIPIEAIVKQDILRQGIHFLKEVFEVTDPYKTKDYFIFSFDHIPLSELGDVKAPEEIKVSGGHFDLLPTVISTRNNPSSPYKVKKSSDGKPVLYLGETFLGNLEFPPLPAWYRHKTKNGKIPGEIAPVIEWGYLIYLTVFRNCQYFGKEEECAYCDINHNYRQQKNAGRPYTGVKDIEDILEVLSWIDSEDHTAKVYTITGGSVITSLKKKNEIDFYLDYATAIESKFPGRWMGKIVSQAWEIEDCKKFKEAGIQVYHPNYEVWDKNLFQKICPGKEAYIGRDNWIRRVVDSAEVFGPSYVIPNFVGGVELSKPYGFSTVAEAITSTREGLDFFMSKGIMPRFTAWCPEPYTTLGTQAGPPLEYFCELLTVWKATFEKYNLPIPPGYGEPGPGKAVFSVSAFMDVIGYSGRN
>NZ_CP048830.1|WP_154213693.1|2006299_2006566_+|hypothetical-protein
MNAKFLLLGLFLSLNCYTGPYRYYDDCSLQYSIDCGRNFDYRNRSGYYPYRNHSNYYKVINNGRYRHNPFYVPSGRFHNFGRPSKWKF
>NZ_CP048830.1|WP_001113029.1|2004718_2005816_-|DNA-alkylation-repair-protein
MPDLLKDLYSKNVLERIAISFSKEIPSISEKEWIQKFKQKDWKQLELKQRIRRIGEVLAEVLPKPFPQSLLKITDSLEKSFEGKEIFLTIFLGDVVEILGIDYPKKSMQAIERITKLISCEFSIRPFLIRHPELTWKQMLEWSSHEHPGVRRLSSEGSRPRLPWGMGIPGLKQDPEKTLPILENLKDDKDEVVRRSVANHLNDISKDHPDLVLKIAQQWIGFSKERDLLLKHALRGLLKSGNSKALAIFKFDSDVKVKISNLKLKSKTVKIGEDLFFSFTVRSEQSKQTRLRIEYKIQYAKISGKTSKKVFQVEERLFQPNESTSYQKKQSFKQMTTRVHISGKHVLEIYINGNLKSKTDFQVIV
>NZ_CP048830.1|WP_000873009.1|2003712_2004393_+|TIGR00266-family-protein
MKYEILLKPDFPIVQVQLNDGESIRAESGAMVAMSPTVKMITKAEGGVFASAKRALLGGESFFQNTFKSEGGTGTLFLTSATQGDIEYRKMNGEDLILSRGAYVAGSESITIDSKWGGFKGFFSGEGLFFLKVGGTGDLFFSSFGAIHTIDVNGQYVVDTGHIVGFEGTLDYTIQKVGGLKSLFLSGEGLVAVFSGSGKLYIQSRNQNSFVSWANQWRRVEKSSSD
>NZ_CP048830.1|WP_001019283.1|2003025_2003700_+|TIGR00266-family-protein
MNIEIISKPSYSFAKVLLNGGESIKAESGSMMSMSSGITIQTHKAQQGGFFKSLKVAFLGGESFWMNTFTASSGNGEVLLAPTLPGDVERIELSGTVYVQSSSFLASSPNIEMDTKFQGLKGFISGESLFFLRLSGNGFLLISSYGGIDVLNVDGEMIVDTGHIVAFEEGLNYEMTKFGGWKSFFLGGEGFVARFKGKGKVWIQSRNVPSLGSWFRNQLPPIKR
>NZ_CP048830.1|WP_001105364.1|2002344_2003010_+|TIGR00266-family-protein
MNYEIIHKPSYSFLKVKLSPGQTIKAESGAMVYMTPGIDVETKMGSGFLSAISRRFFGGESFFFNVFKASVTGGEIGLAPELPGDVVGIDLTDTGLIVESGAYLASDETISIKPMFGGIRSFFGGEGIFLLEAFGNGKLFLNAYGGIIPIDVQGSYTIDTGHIVAFDKSLQYKIAKAGGSWKSTFFGGEGLVMEFTGHGRVLIQTRVPSGFLSWLTALLPN
>NZ_CP048830.1|WP_000194186.1|2001593_2002262_-|SDR-family-oxidoreductase
MTQRNILITGSNRGIGLELTKQFLSQGDQVFALCRKSSSELIHLKPTRIFEGMDVLNSNSIRDLPSKLLDTKIDILINNAGILIPDNLQSLDEENVFTQFLVNALGPLKVVKVLLSSLKKNAKLIFLTSRMGSIADNNSGSYYGYRASKAALNAIAVSLAKDLSPRGISVGIFHPGMVATRMSGGQGISITESVEGLIKRIESLNLQNSGKFFHQNGEELPW
>NZ_CP048830.1|WP_000659012.1|2000244_2001150_-|UDP-3-O-acyl-N-acetylglucosamine-deacetylase
MKEILYRRSIQDTVRIKGIGLHSGKEVNLTAHPAPSGTGIVFEYRKGLEKASISAELSNVVDTSNATTLGDGIHKIQTVEHLLAAVYALGLTDLILEIDAVEVPIMDGSSLPFLQALESAGIIEYPEIVEPIYIQSPLWVVDGDKYLVLLPSDELKVTYTIDFNHPLLKGQSITVSLDREKIKQEILPARTFGFLKDVEALQARGLAMGGSLDNAIVLTQDGYLNQQLRFENECVRHKILDLFGDISIAGRPIIGHYLASKAGHALDISMAKLVMSNVTGDEISKYKSRRIPLFKRKAVVV
>NZ_CP048830.1|WP_000433870.1|2012142_2012442_-|hypothetical-protein
MEPVENSHLGPPSEEIKKLIYHSIIRFLSNRETPISRSEIKELLEKTINLIPDLEAHWAEINRFGKNKMILHWKKKVMLIDMEEILESIDLLWNQRFDI
>NZ_CP048830.1|WP_001068719.1|2012429_2013335_-|lipoyl-synthase
MNPLKKKPRTHSLQNAPEKPDWLKVKLAFPDPKNNPVAIVRNSLEEKKLNTVCESASCPNLNHCWSRKTATYMLGGDICTRRCSYCDVASGKPFPLDPEEPKRIAESSIALGLRHVVITSVNRDDLEDGGAAHFAKTVKEIRKGLPDCKIELLIPDLKVKQEALEIIFECNPDIFNHNLETVKRLFPEVAPQKRYERSLDVLKIASARGFLTKSGLILGMGETLEEVKECMQDLASVGVSLLTLGQYLQPTSTHLPVKEYVVPQVFKDLRIYGKSIGFKGVFSGPLVRSSYHADEQISWNP
>NZ_CP048830.1|WP_001053850.1|2013434_2014175_+|rRNA-pseudouridine-synthase
MNLSEMEEFMQHLEIRLNRFLADCGLGSRRKTEELIQKGHIEINGKRVTNLGTRIDPEIDVVSYLGDVVKPIVESKKILIFNKPIGYLCSHADRFHEKTIFSLLPSDYKNFKIAGRLDLNSRGLLILTNDGALAQKITHPSNGSEKEYLVTLKHDPGEKLIQAAFQKGILDAGEILHAKMVKLVPGKKCVYRVILEEGKKRQIRRMFRWFGVSVVDLQRIRIGPLKLEKFNLEEGQYLLAETGIWK
>NZ_CP048830.1|WP_001009415.1|2014171_2015590_+|MBOAT-family-protein
MNFISIEFLLFFLVFYLLYWNIPAKSRKYLLIVGSAFFYSIFSLNFLFHLILVVLINWCLYRYFYEKFWYVKSVVVFNLLNLGLFKYFYLLMEFIGFIFSIPTLQEKTSLDVKFSALFGLAGFEVILPATISYYTFQLISFAVDSKRENFDKKVSLTGFFSFLFFFPVMIAGPILRFDQVRKQFENPTMTPSKLIDGLWLFLRGLVKKGLLSAAILPLIAPVFLSPKDYSGIALLLTCFLFAANLYFDFSGLTDMARGIGKLIGFELPENFKAPFFFQNFGDLWRRWHLTFSLWIRDYIYIPLGGSRKGEFKTSINLIVTFMLGGLWHGANLNFLIWGLLTGIYLSLERLFEVQNWKVFPEIPYIKPILRYLFVLLVYSISWTFFFTPNFNSAISSIVRILTFQKGQSLTGLETGMYMLFFLFLFHVSEEWPERYSVPEKWRVGLLPILGLLILFIMVGMNAGNADFFYSRF
>NZ_CP048830.1|WP_000725565.1|2015603_2016650_+|DUF1574-domain-containing-protein
MKKIYIYYPILFLGFVFCLDKVFTLEYFQKNFIQAGNTVYYTQRKSLFEKLIRDKDLEVKSLALAFGDSRAYPYSSMGIEQKLQKDWVLYNFSGPQAVPAYGLYWFEKIIKQGLKPKLVFYVVSPEGFDDTKGIFYDPFLKYGADDDFLLKYMDQISFEDRKKLFLDRLFAVRRINPDLKLFIKRFQEKKLSEYDPAFNTDYMVLNLKRGEQFAYTTFVNDPDRLEKDAVRIRNLYLSTFILGTTQFFFVEQFLKLAKENDVKVYLIWPKVYETYRKRYYELEMEKSWWPKIENLAKRYSAVPVDLNTQTSCDLFYDASHQSIMCFLESMKLMIDDYYGFKKIPLYHP
>NZ_CP048830.1|WP_000021495.1|2017801_2018077_-|hypothetical-protein
MSIEYHTSTRLTIEQIQILETSILNNGNYILLETSLQNKFQPENLKFRLSDNHGSFYVEIVQTENGLIVSFRISTKKDRETFLNLVITSLK
>NZ_CP048830.1|WP_000424879.1|2018231_2018876_-|fructose-6-phosphate-aldolase
MELYLDTANVDEIKEIASYGLVDGVTTNPSLIAKSGRSFKEVIKEICSIVSGPVSAEVLSTKFDGMMKEALELVEIAENVVIKVPLIPEGLKTVVELTKRNIPTNVTLCFSAPQALLAAKAGATFISPFIGRVDDTSWDGMELISEIREIYDNYGYDTRILAASIRGPIHLKESALRGADCATMPHSAFLQLFKHPLTDIGLEKFLEDSKKLKW
>NZ_CP048830.1|WP_001217817.1|2019055_2019787_-|hypothetical-protein
MRIFALLFCLFLISTAELFAQLPDETPTPNRRQPTNTTQQAINLLEGFAESSWGESYANLREKFLSLSTNPQNDEKVEIVYEDKEKTLLIRRNGILYSYRFYSTPKIVTESRPKDQRQPTTENKSEIEEENHSAPGVLFSVGVLFRYLPGKEVQQKLEQKYGKPKKESLAENKIGGAVLWEKTDEKQSPPRGGYVVQWKEAYKKMPFTRRVDYFSSSIKFQIEKEYKEFFNAEEIKTLRDLIP
>NZ_CP048830.1|WP_000394962.1|2019817_2020444_-|hypothetical-protein
MEFLLYLIFFGIVSILLVLASYYFKLLFLSGRESFERLELVDWIRIVPNELIKLLESGGSLQYAGIAFFVSAFVSYLWTLLGGMIGAPHYADSFGNYFFLSFLLPVTLLTTYGILVELVLKDLPSTNPNHFLVLFLEQEVAILSGCSISVIASNLAVYGLFHEISFLFVFPNISIIAVLLVLRWNGKVKIGGIQFSGSKNRSFQEDSE
>NZ_CP048830.1|WP_000614725.1|2020446_2021982_-|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase
MIQIKRALISVSDKSGLVEFAKFLNQNGVEIISTGGTLKLLKDNGIAAIAIDDYTGFPEILDGRVKTLHPKVHGGLLGVISNPAHKQKMEELKIPKIDLVVVNLYPFLKTVSKPEVQLEEAIENIDIGGPSMIRSAAKNYKHTLVLTDPNDYKEIQNLISSSGISEEISASYMRKAFSHTAMYDAAISSWFYKQSGEVFPDVLNLSFIKKQKLRYGENPHQAASFYEPLFTKSDFSPLQGKELSFNNMLDFDAAFHISSLLPENTVCIIKHLNPCGIAYADNPLEAFQLARRTDPISAFGGVIGIKGQVNGELATSITENFVEGVIAQKFTQEALEVFSKKPNIRLIEIQDFKEALDELDLRPIHHGLLIQDRDYTTITEKDLKVVTKKQPSPDDIRGLMFAWSCVRFIKSNAIVYTEENATLGIGAGQMSRVDSVQLGANKALNVGLSVVGSYVASDAFFPFRDGIDTLAKAGAKAIIQPGGSVRDEEVIQAADEHGLIMVFTGMRHFRH

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Crispr_ID: NZ_CP048830_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048830_8

2798121-2798212

Orphan

Consensus_repeat	Method
ATTACGTCTCTTTGTAACTCACACTTGTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP048830_8

>merge|NZ_CP048830|8|2798121-2798212|CRISPRCasFinder
ATTACGTCTCTTTGTAACTCACACTTGTTGATTCATCAAAACTTTCGTGGGAGTTCCCACAACATTACGTCTCTTTGAAACTCACACTTGTT

>NZ_CP048830|8|8|2798121-2798212|CRISPRCasFinder
ATTACGTCTCTTTGTAACTCACACTTGTT	GATTCATCAAAACTTTCGTGGGAGTTCCCACAAC
ATTACGTCTCTTTGAAACTCACACTTGTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048830.1\|WP_000414123.1\|2800678_2802460_+\|3-oxoacid-CoA-transferase	unknown	unknown	gnl\|CDD\|366487
NZ_CP048830.1\|WP_000360484.1\|2795214_2796504_+\|3-oxoacyl-ACP-synthase	unknown	unknown	gnl\|CDD\|238424
NZ_CP048830.1\|WP_000517498.1\|2786628_2787153_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000444619.1\|2809423_2809795_+\|DUF1987-domain-containing-protein	unknown	unknown	gnl\|CDD\|378154
NZ_CP048830.1\|WP_000821597.1\|2789071_2790082_+\|flippase-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|377103
NZ_CP048830.1\|WP_000014613.1\|2802493_2803462_+\|ketoacyl-ACP-synthase-III	unknown	unknown	gnl\|CDD\|238426
NZ_CP048830.1\|WP_000686848.1\|2803486_2808829_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226415
NZ_CP048830.1\|WP_000636852.1\|2797016_2797826_-\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|223704
NZ_CP048830.1\|WP_000653653.1\|2798270_2799029_-\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|180440
NZ_CP048830.1\|WP_000603361.1\|2787149_2787815_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP048830.1\|WP_000970449.1\|2808866_2809421_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000129836.1\|2799395_2800250_-\|thioesterase	unknown	unknown	gnl\|CDD\|372545
NZ_CP048830.1\|WP_001247263.1\|2812153_2812612_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|372667
NZ_CP048830.1\|WP_000836871.1\|2791840_2793154_+\|DUF1554-domain-containing-protein	unknown	unknown	gnl\|CDD\|369437
NZ_CP048830.1\|WP_000834630.1\|2787811_2788708_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NZ_CP048830.1\|WP_000131883.1\|2788704_2789055_+\|histidine-triad-nucleotide-binding-protein	unknown	unknown	gnl\|CDD\|238607
NZ_CP048830.1\|WP_000393747.1\|2796514_2797042_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000435433.1\|2809823_2811284_+\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143636
NZ_CP048830.1\|WP_001049277.1\|2793453_2793864_+\|response-regulator	unknown	unknown	gnl\|CDD\|381113
NZ_CP048830.1\|WP_100207446.1\|2813000_2814148_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853

Protein	Function_ID	Function_description	E-value
NZ_CP048830.1\|WP_000414123.1\|2800678_2802460_+\|3-oxoacid-CoA-transferase	gnl\|CDD\|366487	pfam01144, CoA_trans, Coenzyme A transferase.	1.14156e-36
NZ_CP048830.1\|WP_000360484.1\|2795214_2796504_+\|3-oxoacyl-ACP-synthase	gnl\|CDD\|238424	cd00828, elong_cond_enzymes, "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as primer substrates, as well as the nature of their active site residues.	1.86065e-114
NZ_CP048830.1\|WP_000444619.1\|2809423_2809795_+\|DUF1987-domain-containing-protein	gnl\|CDD\|378154	pfam09345, DUF1987, Domain of unknown function (DUF1987). This family of proteins are functionally uncharacterized.	3.6129e-53
NZ_CP048830.1\|WP_000821597.1\|2789071_2790082_+\|flippase-like-domain-containing-protein	gnl\|CDD\|377103	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region. LPG_synthase_TM is the N-terminal region of this family of bacterial phosphatidylglycerol lysyltransferases. The function of the family is to add lysyl groups to membrane lipids, and this region is the transmembrane domain of 7xTMs. In order to counteract attack by membrane-damaging external cationic antimicrobial molecules - from host immune systems, bacteriocins, defencins, etc - bacteria modify their anionic membrane phosphatidylglycerol with positively-charged L-lysine; this results in repulsion of the foreign cationic peptides.	7.39007e-37
NZ_CP048830.1\|WP_000014613.1\|2802493_2803462_+\|ketoacyl-ACP-synthase-III	gnl\|CDD\|238426	cd00830, KAS_III, Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP. KASIII initiates this process by specifically using acetyl-CoA over acyl-CoA.	4.48091e-105
NZ_CP048830.1\|WP_000686848.1\|2803486_2808829_+\|AAA-family-ATPase	gnl\|CDD\|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	0
NZ_CP048830.1\|WP_000636852.1\|2797016_2797826_-\|serine/threonine-protein-phosphatase	gnl\|CDD\|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	2.52104e-49
NZ_CP048830.1\|WP_000653653.1\|2798270_2799029_-\|glucose-1-dehydrogenase	gnl\|CDD\|180440	PRK06172, PRK06172, SDR family oxidoreductase.	8.54772e-99
NZ_CP048830.1\|WP_000129836.1\|2799395_2800250_-\|thioesterase	gnl\|CDD\|372545	pfam13279, 4HBT_2, Thioesterase-like superfamily. This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.	6.46845e-11
NZ_CP048830.1\|WP_100207446.1\|2813000_2814148_-\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	3.57063e-53
NZ_CP048830.1\|WP_001247263.1\|2812153_2812612_-\|VOC-family-protein	gnl\|CDD\|372667	pfam13669, Glyoxalase_4, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.	1.35637e-36
NZ_CP048830.1\|WP_000836871.1\|2791840_2793154_+\|DUF1554-domain-containing-protein	gnl\|CDD\|369437	pfam07588, DUF1554, Protein of unknown function (DUF1554). A family of proteins identified in Leptospira interrogans.	3.62653e-45
NZ_CP048830.1\|WP_000603361.1\|2787149_2787815_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	3.80325e-92
NZ_CP048830.1\|WP_000131883.1\|2788704_2789055_+\|histidine-triad-nucleotide-binding-protein	gnl\|CDD\|238607	cd01276, PKCI_related, Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a hydrophobic residue) that is a signature for this family. No enzymatic activity has been reported however, for PKCI and its related members.	1.59241e-57
NZ_CP048830.1\|WP_000435433.1\|2809823_2811284_+\|GAF-domain-containing-protein	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	4.10113e-74
NZ_CP048830.1\|WP_001049277.1\|2793453_2793864_+\|response-regulator	gnl\|CDD\|381113	cd17569, REC_HupR-like, phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains. This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	2.23906e-25
NZ_CP048830.1\|WP_000834630.1\|2787811_2788708_+\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	6.83767e-74

>NZ_CP048830.1|WP_000636852.1|2797016_2797826_-|serine/threonine-protein-phosphatase
MIVNYFGITEKGNFRSHNEDSMYVSGEIVAGTVSGSFSSSGMREAPLILALADGMGGHISGEIASRMTLEKLAWTERAVQPLDELSRAGWQSLFSIINHEINDYAKETGKLGMGATLVGILFGKRKVLVFNMGDSRAYHFSSQGIQKITVDHSFAGPVKENQVSRSYITSCIGGGTTDLQMDLFDITNSLNVGDRILLCTDGLTDVIKIDDLEEILKNSSNAKEACYHLLEEANLRMTKDNTSVIVIEVQEIILSNSKPWKLTPGEKKR
>NZ_CP048830.1|WP_000393747.1|2796514_2797042_+|hypothetical-protein
MEFDRLYRQYDYLKKLKSVLYYQGAVTHEVLGNLTEILKDRITNQKGKNKILNVFIEMVQNVSHYSLEKEGDYGVGLIIVKEKNHILKLSTANLLSEETASTLEKKLDHFLSLSEAEVKELYLQKIKGERPKSSKGAGLGFLEILRKSDFPFRSSFEKTPNGNFFFTLTVFFRLG
>NZ_CP048830.1|WP_000360484.1|2795214_2796504_+|3-oxoacyl-ACP-synthase
MDKPKTNHNSRVAITGIGVILPNTYSVDTFWKNLSEGNSQIDTITRFPTDDMPVKVAAEMNDFDWKKFLPDLDEKHSKHYNRETFAIMSAMEEARRDAKLEKDSVDPSKVGFIDSSSRASLAWWEHAWKLYHEEKDPNVFDRYSVLTSMASNPTNLTAIYANVQGFVTTITAACVGGHHAISLCYQAIRKGRAEVMYAGGHEFPLIKPLMMMYSDPVSSVMSSEKDNPKSAIKPYDRNRDGFILGEGAAVLCMERMDHAIARGARIYAEVLGTFSYNEADHAMRMDLTGKKAANGLNRLLKISGLNLGDIDYFCGHGTATINNDMAESRALKILYNGLARNKWAPLGSIKPIFGHTFGAAGIINVAATALMLEKQILCPTINLKDVDPECDHDHITDGARKVRLRNAISMAFAIGSQSSFVSLTAPDLL
>NZ_CP048830.1|WP_001049277.1|2793453_2793864_+|response-regulator
MNLKDEPNAILCVDDEPIILISLVQELKNKLGREFIFETAQDATEALEVIDDLVSKGTKVVLIVSDWLMPITNGDEFLIQVHKKYPEIPSILVTGHIEEGIFKKVQQEAGTCMIIPKPWNSEELLKVVRKFCYDTK
>NZ_CP048830.1|WP_000836871.1|2791840_2793154_+|DUF1554-domain-containing-protein
MKSKFKFVAVLTLTGILFLFSCSETQDGSDNTLFTLLSLLGEKNKPASAGFHYGKLTDEDPSDVEAGSENLLPSSPTYIFLAPAHHGGLGGIYGADEWCMRKVPADLKGSPYYSYKALLADGINRRASVTGNAGDGQINWVLQASTVYSQATTGTPTIGTTNSKKLFTFPLTNKIRPDSITDFGSITWTGLNPNWTTAPYNCNNWTDGADINVGTIGNYNATSSNAIFDSALIVPGLITCSSGGKLYCVEQPAPPIRFFKYIYLAPLSPIGHNGNYGGIAGMDTICNNDTMKPVELLGKGTYKAMAVDQSITIPSTPATRRATPNPLNWVLRPNTTYKRVDGATLFTTDINGLFSSMTNRFGEETENNGYIWTGLNSDFTTATGYNCNNWKSSASNYLGKIGSANTNVKSVALSYTNRPCDQTTNSSEPIRVVCVEQ
>NZ_CP048830.1|WP_000821597.1|2789071_2790082_+|flippase-like-domain-containing-protein
MKRILFGSLVSVFALGFLFSKLDLSEFSKIQERWEPIYLIPFVISSAWGIVLFSWRWYLLMEKQVSFRYALLSSFIGVGANMFLPARGGDIFRLYFCKKESSLQYPTLVTALFIEKVLDFSFIFSAGICALMFLGINDESSNSFLIISSLVIVGIFLGLIAVRFLNNTIIEIFAWIAGLFGKKEWFLHKLAHYIRDLGNFLVFKKFIFPAFLTAFTWLIGYAFSYGILLKLVDIDISYTGIVLIMFAGAVGVMVPSAPSGAGVFHASVTSSFVLMGRKASEGLFYATTVHLAQFIFQSIFAIVLYLYWIVDRRKRGLGKAEFSLKESEVIEVESSE
>NZ_CP048830.1|WP_000131883.1|2788704_2789055_+|histidine-triad-nucleotide-binding-protein
MTDPNCIFCKIIRKEIPSKVVFENDEILAFYDISPQAPVHIVFIPKKHIPSLSEIENEDSHLLGNILLQIRDTAKNLGFAENGYRVVNNTGKNGGQTVFHIHFHLLAERRLHWPPG
>NZ_CP048830.1|WP_000834630.1|2787811_2788708_+|ROK-family-protein
MKSFLGIDIGAGSIKASLIDSNGNVLKSSFRKTGAETNEKQFLDSICDIVSEMKNSSLTAVGIGSPGPIDSENGILIESANLPLLKNVTLVSHLKEKFSIPVYYNNDANLAALGEYHFGLGKGSPNLVILTLGTGLGGGWVYQGKLFNGYKGSGMEAGHVTYLPNGSLCGCGQRGCTEAYFSASGFLNRYKEKTGEVLDSAEEFFEKTRKGDKTASILLNEGIDALAQLCRNLIHTINPEKIVFTGGLVKSWDLFGDSLQNRIRELIFPIFRTYTQILPGGNVSGTLGAAALCMENLE
>NZ_CP048830.1|WP_000603361.1|2787149_2787815_+|ABC-transporter-ATP-binding-protein
MILRINNLSREYGKSKAVNGVSFDMNQSDYVAIVGPSGSGKTTLLSMITGMLSSTSGEVYFDTTKVSDMSNGELGNFRAKNIGLIFQFSELLPHLDVEENILLPALLVSKFSPKEYLEKCEYLIRSLHLESIRKSYPSKLSGGQIQMTAIARSLINEPELLLADEPSGDLDPENSELVRNLLYDFNSRGLTILLVTHDMNLAFDAKTIYEMREGEFTRVVK
>NZ_CP048830.1|WP_000517498.1|2786628_2787153_+|hypothetical-protein
MGKLTYFRFAYSIVKRDITISILHIGFSSLFCFFLIFGIFLLRMDRTPSNSSSIELFRNYPQLVLLLSSSGLVFMAITRTLLRTSDAGIMMAVGGNRIGTVRLLVSELWILHGTGFFLGILTTIFFPPWVAEGSSLFDYGKAFFICIFLISGIGSILSLILTFLDPYRSIRRGK
>NZ_CP048830.1|WP_000653653.1|2798270_2799029_-|glucose-1-dehydrogenase
MKDKVAIVTGGSTGIGKAVVKEFVSKGVKVVFCGRRLEEGKKLESEIRAEGGDVYFVVCDVTSGEQVKKVVDAALEKFGRLDFGINNAGIMGLNHLLHEYPEDVWDKVVNVNLKGTWLSMKYQIPEMIKMGGGVVVNVSSISGINGVVGINPYAAAKHGVVGLTKSAALEYAKKNIRINAICPGAVKTEILDELFHLAKDPVEAERQLVKLHPIHRIASPEEISKTVLWLCSEDSSFITGTAIPVDGGYSAK
>NZ_CP048830.1|WP_000129836.1|2799395_2800250_-|thioesterase
MTDIQIEFPEKYHFSTELSIRKTDLALDIHVSFASILDLVMEAHLQFFQYLGFSVTDIYGKSIIFANAGILYQGELLYKDQVKIDVVLDNLGEKSFDLTFRLSKDQRKEKVALIKIRVLFFDYSIRRVVSVPEGFRKIFTEERIPVYTSSQTEMVQETSSVQSKSFDKLEVLRFAHGLTLKLYRIGNKTEVIKEHSSLLEHIRSVSILLPVRIAGAWGSRILSEKIKNILKAKVHLEELRYLLVLLQDLKIDSIESELSDLEIINKHLKKYLARVRNGKTRKLN
>NZ_CP048830.1|WP_000414123.1|2800678_2802460_+|3-oxoacid-CoA-transferase
MEKNAKIFQNPDEMIRETVQPKMYLHLSATMSRPNALIYSLARCFQNSNPEFIISMAGIHSSAHALTISKVVKKMITGFAGDNYPKPAPNSLYSNLLEGKPFELELWSLLSIVQRLMAGAMRLPGFITNSLLGSDLILDKLGKTAFLLPDPKHQGINGSHSPNYKGKKGVDLVYILPLNPDLTLLHAVVGDEEGNLVLCPPCGEGYWGALSAKQGVVATVEKIVPKGSIPPELVSIPGNRVKAISIAEFGAHPQSLRVYNLSGIPAFAGLSTYLDDYEFQIEANEAANAPSRAEKWYADFVNLKGGHAEYLERIGISRLKRLKQIPKENKVTKLEDPKTVNDSEQMIILAARAIQEYVKSNGYKTILAGIGAAHISAWTAARFLEKEGIEVKIITELGFFSMKPHTGDVFLFSQLHAKDCTMLSDITSILGTVVPDHCLGVLGAAEVDWFGNINSTKTSKGKFLVGSGGANDIAAVADCIVVAKANRGRFVKHVNYITSVGDRVMEAVCQFGRFQRTPNSDHVFEFSHWISPPSDEEMEPEEAVLRYTSWLPPDEDIPLKHEPPVTAEELTVLRELDPEKIYIEQFMVYTRLP
>NZ_CP048830.1|WP_000014613.1|2802493_2803462_+|ketoacyl-ACP-synthase-III
MSGKNQSGIQITGFGHYLPEKIVTNEEIRSRLKFPEMHPAEKAVIGNIGVNERRRANESETPMFMASKVAEMALKDAGKKPDEVDLYILANWTDRYYLPDLAPQASKLSGTKNALAFDVSTACTGFVHGVQTACAYLESGKFKNALVIGSERFSVRTRMGGYGEFTAGDAAAGVFLEHTGNSNSGIIDSFLQDEGDLAGIIVTGPPPNSYVKSYPELVTNAADLTLKAMDKLLEKNGLTIDDVDWVVPHPGTDVVVQDVLKRTRFPKEKILMNFDKVGNTSAASIPIVLSEYYYKGKFKKGDLFLTPAVGGGFYWGGLLFRL
>NZ_CP048830.1|WP_000686848.1|2803486_2808829_+|AAA-family-ATPase
MKIDGYEIKDRMNTDSSTEVYKAVRSKDKTEVVVKYIPILDELHPAVVNLRNEYEILSYLSSEKMIRAFGMEKIPEGFILILEFVPGQSLKHFSQKRPVNLKDFFKIAIDLAEKLGEIHNKKVIHKDLKPDNIIFNPDENILRIVDFGISTRLSKEESSWSNPNRLEGSIHYVSPEQTGRMNRSVDYRSDFYSLGITFYELLTGKLPFESEDLLELVHFHLAKSPVDPRKIRSEIPEALSHVILKLLSKTAEERYQTSEGLKNDLEIIRDKWLESGDAPAFPLGSTDYSHEFKIPQKLYGRESYIEALLNEFKRMTETGRPSIVLIAGYSGVGKSSLVKEINKPLTESKGYSISGKFDQYNRNVPFSAIIQVFSNLIEQILTESPERIEEWKNKIRDTLGANGKVITDVLPELEFIIGEQPPVTELGPQENANRFYLVFQNFIKIFANQDHPLAIFLDDLQWADTPSLELVKNLIEDASVNYLFLILAYRDNEVDSTHPFSALISGLEKEGFRLDKILLKPLSLENVNELLSDSLRRPTEETMSFAEIVYSKTRGNPFFINELLKQLSKEEIISYQKGSPTDSGRWVWNLEKIKNTNISDNVVELLVNRIKKLPPRTQETLKLASCIGSNFDLAIQAKILGATLKETAEALMETMQEELIVPIGDNYRLVDSMVEIEKNQDKNFQIAKSIQFRFQHDRVQQASYELLNDDQKQSLRLQIGRILLENLNEKTLEDSIFDVVNHLNTGSTLITDNSEKRKLLQLNLQAAQKAKLSAAYKPSKLYCLQAKELLSSLCKSEKDCWNQEYDLSYAVHKELAEVLYLNGDFEESQETIQDILKQAKTPVEQAEAYNLLMIEYSAQGKYDLAMPTVIKALKPLGIELPTSGFDKVVKKELEEAKKNLKNRSITSLLDAPTMTDPSHIWAVNLLISAIPMAYNKEPALFPVICLKMANLLLKFGNLSDSYGYSCYGMVLVGQGDYKGAYDFCELAVKLSEKYINSGGYTKAANILANYSSSFVKHLKFSEEINIKCVQSALDSGEFLHGSYAAMNDASNVLFQGKNLEILKPKINELLKFVRKVKNNLAIDTILGTTLILSNLRGETGSHLDFSSTEYLEKEYIDLCNDHQSLAPICTFKVMKVRSLLMYGEYQLALQEAEETNGMILYLGGQYGPFEYNFLYSLALAANYKKVSPDRKKESVKKIRENQKQLLVLAESCPENFYHKYLLVEAELARLEYKNWKAARTYEAAIREARKNEFQNDEALACENAALFWLSKGSVKIAGEFINEAYHRYGLWGANLKQSMLKSKYPEFIRERGTGLLRTHRTISSTTSTATEIYSGQTLDLQSVLKSSTAISGEIKLENLLDKLMKIVIENAGAQRGVLILKKEGKLYVEAEGSISKDDVEVLTGIPLGSSKNLPISLIYYVERTKENLVLRNASQDEKFNKDEYIKNFKTKSILCTPVIKQGEISGILYLENNLSEGAFTSDRLQIMNILSSQAAISIDNALLYSNMEEKVRERTRELAQANADLELKNQRITDSITYSLNIQQAILPSDDILAKNLKDQFVLFRPKDIVSGDFYWFSKKEGSIFLAAVDCTGHGVPGALMSMIGNTLLNQIVNEAGIKDPGKVLEHLNRNVRQALKQDTLGANSSDGMDICFCRIDEDKVLFAGAKRPLYFSKGNHIEEIKGDKHSIGGRQKEVSRTYSTHEVKLEKGQSAMFYLTTDGFMDQPNPQRQRITSKGLIARLQNVLSLPAYEQKNQLAAFLDEYQAGEAQRDDITLIGFRV
>NZ_CP048830.1|WP_000970449.1|2808866_2809421_+|hypothetical-protein
MMENKSLDLFKQYRDTYDYQFIVSFKGRLSQEVLTEFGSMIRTSLSTESKIKKIFAVFIELAQNMLHYSAERKSLEDGRETGVGIIMVDEKSVGYNVSAGNLVLNEKIESLKMKCEKINSMSRDELKTYYQKQLRSNRPEDSKGAGVGLIDIARKSDGPLSFNISPIDDKHSFFTLSAYFTKEN
>NZ_CP048830.1|WP_000444619.1|2809423_2809795_+|DUF1987-domain-containing-protein
MESLHIQQTKTSPEVILDTEQGFVEIIGESYPENAIAFYKPVFDWLNAAMNSKSKIQVKFQLDYFNTSSSKVIMDILDSLQKYHDQNGKVKVLWLYKEDDDDMQETGEEFSSDLSLPFELKSY
>NZ_CP048830.1|WP_000435433.1|2809823_2811284_+|GAF-domain-containing-protein
MEQKDFNSFFENEFQLLNEVNEILDNNDSLNKENLIDELRKIGEAYESLLKQSSKLMKIGDSTQNRLIKTQTELQDSNQRLVSSYQNLKQLSEIGQMITASLEPKIILTSVYENTKSMLSMDVLAFGIIEEGKNEIKYKFSLIEGRYTPAPTVDSLTEDNPSSFCYHNNQELITNDLEKDFPGYVSVIQKHFGEKTNSVVYLPLKVEERFIGILTIQSFNKNEFNENKLNILRTLANYVAIGVDNADAYKNLSKRNRELKDSLEKINILNKGLEKERQKSESLLLNILPKSTAERLKAGEVVIADYIKKSTVLFADIVGFSKLSTQIPTPNQLVEILNQIFTCFDDIASKYQLEKIKTIGDCYMMAGGIPIATEDHVEKIALAGIDMIQGLKDLQKSWKYEFNIRIGIHTGDVVAGVIGKNKFVYDLWGDSVNTASRMESHGEPGRIHCSEAVYESIKDLFLFEERGVIPVKGKGPMRTFFLLGKK
>NZ_CP048830.1|WP_001247263.1|2812153_2812612_-|VOC-family-protein
MRPFKILGIQQIAVGGEDKKKLETFWVDILGLEKAGTFRSEKENVDEDILRMGKGAYAVEVDIMQPIDVNKSPKVHEPKLNHIGLWVDDIHKAVEWLTTKGVRFTPGGIRKGAAGYDVCFIHPKGNEEFPYSSEGVLIELVQAPADVIQALS
>NZ_CP048830.1|WP_100207446.1|2813000_2814148_-|IS3-family-transposase
MNKKGKYSPEFKEQAVKRTLSGSFTIKEVAGSLGISYFVLRQWRGEYLKKSEDQLPLTDKQLKESEELKKLRKENLKLKEEVNIPKKVCRHAFPRTKSRLMFMETHRFEYSIQSMANVLGVSRSGFYQFLKRSKNELEKYNPELVEFIRETWLTSRKNYGLVRLLREVKKVYSIYGARTVRKVMKLCEIQGKQEKRFRIATTDSNHGNRVAPDLVQRNFKPNQKNRIWVSDITFLRSSFGWIYLCVILDLYSRKVVGWSISNSNDSKLVCTALSKAIECRNPPKGLVFHSDRGSNYCSYETRRYLLNNKLRRSNSRKGNCWDNAVAESFFGSLKREMEYNYFYKIQEAEELLFDHIEVYYNRHRSHSSLDFVSPVQFEVNAA

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Crispr_ID: NZ_CP048830_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048830_9

3087120-3087222

Orphan

Consensus_repeat	Method
TTTTTTAATTTCATATCAAAATCTTGATCGTTTTAAGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP048830_9

>merge|NZ_CP048830|9|3087120-3087222|CRISPRCasFinder
TTTTTTAATTTCATATCAAAATCTTGATCGTTTTAAGAGACGTAATTCTGTGGGAACTACTGCATTTTTTAATTTCATATCAAAATCTTGATCGTTCTAAGAG

>NZ_CP048830|9|9|3087120-3087222|CRISPRCasFinder
TTTTTTAATTTCATATCAAAATCTTGATCGTTTTAAGAG	ACGTAATTCTGTGGGAACTACTGCA
TTTTTTAATTTCATATCAAAATCTTGATCGTTCTAAGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048830.1\|WP_000196651.1\|3084332_3085106_-\|outer-membrane-lipoprotein-carrier-protein-LolA	unknown	unknown	gnl\|CDD\|319983
NZ_CP048830.1\|WP_000079210.1\|3092267_3093170_+\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|275263
NZ_CP048830.1\|WP_000358325.1\|3081873_3083187_-\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	unknown	unknown	gnl\|CDD\|273453
NZ_CP048830.1\|WP_000014283.1\|3085564_3086734_-\|DUF1577-domain-containing-protein	unknown	unknown	gnl\|CDD\|369443
NZ_CP048830.1\|WP_000365024.1\|3089729_3091430_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173838
NZ_CP048830.1\|WP_000833715.1\|3077081_3079010_-\|protein-translocase-subunit-SecD	unknown	unknown	gnl\|CDD\|235615
NZ_CP048830.1\|WP_001001361.1\|3087942_3088374_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379324
NZ_CP048830.1\|WP_001072290.1\|3083195_3084311_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379173
NZ_CP048830.1\|WP_000876121.1\|3088473_3088716_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000854852.1\|3095601_3096636_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377013
NZ_CP048830.1\|WP_000971361.1\|3089587_3089794_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000493050.1\|3088894_3089560_+\|protein-L-isoaspartate-O-methyltransferase	unknown	unknown	gnl\|CDD\|178974
NZ_CP048830.1\|WP_000459252.1\|3076138_3077077_-\|protein-translocase-subunit-SecF	unknown	unknown	gnl\|CDD\|237275
NZ_CP048830.1\|WP_001045091.1\|3081130_3081877_-\|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	unknown	unknown	gnl\|CDD\|273139
NZ_CP048830.1\|WP_000499626.1\|3096642_3098373_+\|apolipoprotein-N-acyltransferase	unknown	unknown	gnl\|CDD\|234721
NZ_CP048830.1\|WP_000421034.1\|3094496_3095516_-\|4-phosphoerythronate-dehydrogenase	unknown	unknown	gnl\|CDD\|240635
NZ_CP048830.1\|WP_000377368.1\|3091570_3092290_+\|DNA-alkylation-repair-protein	unknown	unknown	gnl\|CDD\|132880
NZ_CP048830.1\|WP_000723997.1\|3079020_3079767_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275213
NZ_CP048830.1\|WP_000433680.1\|3080145_3081156_-\|anthranilate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234682
NZ_CP048830.1\|WP_000141830.1\|3079763_3080090_-\|preprotein-translocase-subunit-YajC	unknown	unknown	gnl\|CDD\|376903

Protein	Function_ID	Function_description	E-value
NZ_CP048830.1\|WP_000196651.1\|3084332_3085106_-\|outer-membrane-lipoprotein-carrier-protein-LolA	gnl\|CDD\|319983	cd16325, LolA, LolA, a periplasmic chaperone. This family contains periplasmic molecular chaperone LolA which binds to outer-membrane specific lipoproteins and transports them from inner membrane to outer membrane (OM) through LolB, a lipoprotein anchored to outer membranes. There are five Lol proteins (LolA, LolB, LolC, LolD, and LolE) involved in the sorting and membrane localization of lipoprotein and are highly conserved in Gram-negative bacteria. LolA accepts OM-specific lipoproteins that are released from the inner membrane by the LolCDE complex and transfers them to the OM receptor LolB. Studies have shown that hydrophobic surface patches large enough to accommodate acyl chains of the OM lipoproteins and the structural flexibility of LolA are important factors for its role as a periplasmic chaperone.	1.73701e-24
NZ_CP048830.1\|WP_000079210.1\|3092267_3093170_+\|radical-SAM-protein	gnl\|CDD\|275263	TIGR04470, hypothetical_protein_ALIPUT_00462, radical SAM mobile pair protein B. Members of this family are the downstream member (B) of a pair of tandem-encoded radical SAM enzymes. Most of these radical SAM gene pairs have an additional upstream regulatory gene in the MarR family. Examples of high sequence identity (over 96 percent) from cassettes in several Treponema species of the oral cavity to those in multiple Firmicutes in the gut microbiome suggest recent lateral gene transfer, as might be expected for antibiotic resistance genes. The function is unknown.	1.56313e-20
NZ_CP048830.1\|WP_000358325.1\|3081873_3083187_-\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	gnl\|CDD\|273453	TIGR01125, Ribosomal_protein_S12_methylthiotransferase_RimO, ribosomal protein S12 methylthiotransferase RimO. Members of this protein are the methylthiotransferase RimO, which modifies a conserved Asp residue in ribosomal protein S12. This clade of radical SAM family proteins is closely related to the tRNA modification bifunctional enzyme MiaB (see TIGR01574), and it catalyzes the same two types of reactions: a radical-mechanism sulfur insertion, and a methylation of the inserted sulfur. This clade spans alpha and gamma proteobacteria, cyano bacteria, Deinococcus, Porphyromonas, Aquifex, Helicobacter, Campylobacter, Thermotoga, Chlamydia, Streptococcus coelicolor and Clostridium, but does not include most other gram positive bacteria, archaea or eukaryotes. [Protein synthesis, Ribosomal proteins: synthesis and modification].	1.72325e-118
NZ_CP048830.1\|WP_000014283.1\|3085564_3086734_-\|DUF1577-domain-containing-protein	gnl\|CDD\|369443	pfam07614, DUF1577, Protein of unknown function (DUF1577). A family of hypothetical proteins in Leptospira interrogans.	2.61477e-102
NZ_CP048830.1\|WP_000833715.1\|3077081_3079010_-\|protein-translocase-subunit-SecD	gnl\|CDD\|235615	PRK05812, secD, preprotein translocase subunit SecD; Reviewed.	2.95752e-150
NZ_CP048830.1\|WP_001001361.1\|3087942_3088374_-\|ATP-binding-protein	gnl\|CDD\|379324	pfam13671, AAA_33, AAA domain. This family of domains contain only a P-loop motif, that is characteristic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.	1.41408e-13
NZ_CP048830.1\|WP_001072290.1\|3083195_3084311_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379173	pfam13413, HTH_25, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	1.20247e-20
NZ_CP048830.1\|WP_000854852.1\|3095601_3096636_+\|hypothetical-protein	gnl\|CDD\|377013	pfam03280, Lipase_chap, Proteobacterial lipase chaperone protein.	4.17659e-08
NZ_CP048830.1\|WP_000365024.1\|3089729_3091430_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	7.81499e-42
NZ_CP048830.1\|WP_000493050.1\|3088894_3089560_+\|protein-L-isoaspartate-O-methyltransferase	gnl\|CDD\|178974	PRK00312, pcm, protein-L-isoaspartate(D-aspartate) O-methyltransferase.	6.83089e-55
NZ_CP048830.1\|WP_000459252.1\|3076138_3077077_-\|protein-translocase-subunit-SecF	gnl\|CDD\|237275	PRK13022, secF, protein translocase subunit SecF.	1.44272e-88
NZ_CP048830.1\|WP_001045091.1\|3081130_3081877_-\|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	gnl\|CDD\|273139	TIGR00560, pgsA, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis].	4.27529e-35
NZ_CP048830.1\|WP_000499626.1\|3096642_3098373_+\|apolipoprotein-N-acyltransferase	gnl\|CDD\|234721	PRK00302, lnt, apolipoprotein N-acyltransferase; Reviewed.	5.07796e-60
NZ_CP048830.1\|WP_000421034.1\|3094496_3095516_-\|4-phosphoerythronate-dehydrogenase	gnl\|CDD\|240635	cd12158, ErythrP_dh, D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains. D-Erythronate-4-phosphate Dehydrogenase (E. coli gene PdxB), a D-specific 2-hydroxyacid dehydrogenase family member, catalyzes the NAD-dependent oxidation of erythronate-4-phosphate, which is followed by transamination to form 4-hydroxy-L-threonine-4-phosphate within the de novo biosynthesis pathway of vitamin B6. D-Erythronate-4-phosphate dehydrogenase has the common architecture shared with D-isomer specific 2-hydroxyacid dehydrogenases but contains an additional C-terminal dimerization domain in addition to an NAD-binding domain and the "lid" domain. The lid domain corresponds to the catalytic domain of phosphoglycerate dehydrogenase and other proteins of the D-isomer specific 2-hydroxyacid dehydrogenase family, which include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence.	6.516e-108
NZ_CP048830.1\|WP_000377368.1\|3091570_3092290_+\|DNA-alkylation-repair-protein	gnl\|CDD\|132880	cd06561, AlkD_like, A new structural DNA glycosylase. This domain represents a new and uncharacterized structural superfamily of DNA glycosylases that form an alpha-alpha superhelix fold that are not belong to the identified five structural DNA glycosylase superfamilies (UDG, AAG/MNPG, MutM/Fpg and helix-hairpin-helix). DNA glycosylases removing alkylated base residues have been identified in all organisms investigated and may be universally present in nature. DNA glycosylases catalyze the first step in Base Excision Repair (BER) pathway by cleaving damaged DNA bases within double strand DNA to produce an abasic site. The resulting abasic site is further processed by AP endonuclease, phosphodiesterase, DNA polymerases, and DNA ligase functions to restore the DNA to an undamaged state. All glycosylase examined to date utilize a similar strategy for binding DNA and base flipping despite their structural diversity.	3.9365e-09
NZ_CP048830.1\|WP_000723997.1\|3079020_3079767_-\|hypothetical-protein	gnl\|CDD\|275213	TIGR04420, Sec_Non_Glob, Sec region non-globular protein. Members of this family occur only in the genus Leptospira, always encoded between genes for the YajC and SecD components of the Sec preprotein translocase. Sequences have an N-terminal signal peptide and a C-terminal transmembrane segment. Between these are regions of non-globular, low-complexity sequence including Lys-rich and Ser/Thr/Asn/Glu-rich regions.	6.82364e-87
NZ_CP048830.1\|WP_000433680.1\|3080145_3081156_-\|anthranilate-phosphoribosyltransferase	gnl\|CDD\|234682	PRK00188, trpD, anthranilate phosphoribosyltransferase; Provisional.	7.96128e-154
NZ_CP048830.1\|WP_000141830.1\|3079763_3080090_-\|preprotein-translocase-subunit-YajC	gnl\|CDD\|376903	pfam02699, YajC, Preprotein translocase subunit. See.	1.26653e-26

>NZ_CP048830.1|WP_000014283.1|3085564_3086734_-|DUF1577-domain-containing-protein
MSGIKLKERDLDVINSPEQRKHIIEKHLLNQSLRIKGDLNRETITIQRYVDSGEKIIAGISDETHFSENDEIVLYKILAKYVQLECSFIRKTRPGVAEFSVNKVSIAKSNRAFPRYSVAEDAAHVTNINSSKTVIDASLFNIPTLVKVSFEDYKTKLKPDQLGLVEIDVFRSDQDEKFELIKRTKKYIHIENTSLEESYKSKSENQVDVEDEIHEEIPSLMRKYKDEKIVSEIIYPIIYINHSRQSIPLGYIWVRNKEKTLGNNTIEKLAELSKEMVARIKESNTVLTTEKFPIIDISNNGICIKITEPHLIQTLPKHTGFVFDIYIRMQGYFKVFGAIRWLSYDEVGSLILGMELVAKSSFPGEREKFHRNVELLGQGKFTGLKTHAI
>NZ_CP048830.1|WP_000196651.1|3084332_3085106_-|outer-membrane-lipoprotein-carrier-protein-LolA
MTRFPRHLILVKKIPGDPVFLMKKTIILSFFILFLALEPSLLAQPAHNWNSPSEVVKQVKKKFSDLNSYKADFQIQTVSNKKSKNMKGVCLYKKGGRIRYQFNEPSGDEIVSDGKTLYIYIARLNAVGKQDLTLNKSNKSGPIFSNFTDEGLSRIFRKYHYKFDSIEQPQTSSKDGRKYFVLNLEQREKIGGFETMLLYVDAQTYFIQKAVASDGRGKETTIEFSNLEINPDLEDGQFNFHIGGNAKIINNPLVSEQ
>NZ_CP048830.1|WP_001072290.1|3083195_3084311_-|helix-turn-helix-domain-containing-protein
MNQKRVGQILREAREEKKLSVKDVARETNISVKYILALETEDYSQFPGETFTMGFLKNYGGYLKLDTGQLINLYRGEKIEESQAPLEELTRPTASYYTKINVDKNKIFTIASVLIILISAYLIIDSFIGPSSDEDSVEESGKKLDIPENIDFLSRSIPESRSESFILTPDKGVSFSVSNQQCKLFIDSVEKGGAVNTAVLAFNVYPELTVYKFRLSEGQEKILSYTIPEISSLRRNVRIISQAVTENSAKVLVTLSDEEQKQENNNSVDNTKTLGDVPIQVTLFFNKPSYAEFIIDGQMGFRGLVQTGETRSLEAKDRLELKVGDGSAVEMIQNGKPKITLGRPGKLVKKIFVKTQNPYDSTQSIIKELGE
>NZ_CP048830.1|WP_000358325.1|3081873_3083187_-|30S-ribosomal-protein-S12-methylthiotransferase-RimO
MDKKFYITTLGCPKNIADSMSMHHSLLEEGFTPASLPEESDFHFINTCTFIQSATEETIQTILSAAQVKKQNHQKLVVVGCFAERYPDNIHSEIPEVDLFFGTGKYSQAGKILREKFPELSPSQLEFNDSLLERWKLSSKIENYSKPYAYVKVSDGCNRGCSFCIIPSFRGKFAESPLDDILRDTNRAIRAGAKEICLVSQDTVYYGRDSEILLDMVRKVAEIDSLEILRLLYLYPDKKTEKLIRLMGETSKIAPYLESPLQHVSSKILKVMNRTGESSYFKDLFSLAREVKPGLEIRTSFIIGYPGEEPEDVDQILRFIEDTRPEKVNLFSYSPQEGTKGAQLKQTVSEKEKSKRINLIRDSHLEILEEIHESRIGRTYDAIVDGIEDGQAVVRRFQDAPEMDEVVYVDDVSLLPGRIGKVRIDSFYEYDMNGTWV
>NZ_CP048830.1|WP_001045091.1|3081130_3081877_-|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase
MNKVIFNIPNILTMLRVAAVPFFVWFLFQKELEYHIAALILFSVASLTDLIDGYLARKWNQETEFGKFLDPLADKIIVTGCFITFIFLQEQIEFWMVCLIIGRDMLITSLRYLAIRQGQSIRTTMLGKVKTVFQMGAIVLILVFFILISSKKRILINQAYATGKANGLTVFEFATNNAIQFFRNLDQNNGLGDVVFGLGTFVPYWGMLVTTTITVISGIRYLVSNSKVLYPSNLKGMFQKNGTKSSRS
>NZ_CP048830.1|WP_000433680.1|3080145_3081156_-|anthranilate-phosphoribosyltransferase
MEPRAAVLKLIEHKHLTALEAESFMNHVMKGEVSEILLSSFLTAMRFNGESVEEVLGCTLALRKNALRPKTVFPFDLLDTCGTGGDGQGTINISTLSAIVLASLGIKVAKHGNRSVSSHTGSSDILTRLGYQTETTQEEVEAHLVNRGFTFLFAPMWHPSMKHAGPVRKELGFRTVFNMIGPLSNPFSPQFQIIGVYQPELMELFIKVLQSLGLKRALVCHSRDGLDEFSIFQITDYTFLENGVISRHSFDPKILGLSSLNKEEVYASSSDHAEVLARKVLNSESIAGTHAVALNAGAGLFVMGKIDTIEQGYQIAKEAILSGKTKKYFEDLISKE
>NZ_CP048830.1|WP_000141830.1|3079763_3080090_-|preprotein-translocase-subunit-YajC
MTFDILLQLAQAAGEGDKSPFSTLLLIPIMLVIMYFLVIRPQRNEEKKRKEMIDSLKKGDEVVTSSGIHGKVVEIKDNNEVVVLNIAKDTNVSFTASTVLKKKQQADK
>NZ_CP048830.1|WP_000723997.1|3079020_3079767_-|hypothetical-protein
MKKISILILIFLFLGNLALFSQDGEEIDFLEKVTEPKKTVSKKSSNTAGASSGTSTPKKKEKKRSKKKRSKKSSSSIPNNLEETQKKNVIPNTNETSSGNNNSNLNGSNSGSSNTLESGNVDEQRVSASKMDLRDLPKPYWVNEEVQIHPNNLPGYTVSQKSEQGSSFGSGLSEILKLGEDKKKEENKKKVQEVQKSGSFTGFISEYKKPIIIIVFILLFALYRLKAGKSRGSSSRKSPVTINKMRRD
>NZ_CP048830.1|WP_000833715.1|3077081_3079010_-|protein-translocase-subunit-SecD
MKSATWIFLPLLIILAATVILYPNFATRELELAVRKEFISISPEQKKAILSRFEERWNREYKQSDWVISPSPSELKDESFLLVKGRFITSAKINQISQENPELILEAKNKLRPTLVEEWITKGRPLTIKLGLDLQGGMRVAMKGDFEDYASKLRESYIKEIENLNKTVTDPSADEKEKKKAKDRLSEIESYFELSPSRKLLELEKAKLIIDNRLTSQNLTEPQVRIQKDQDSIEVSLPGVTNSSQILEIIQNTETVEYRLEEPENSAGNGLTYASIIQQEENRLLELKRREETDIVQYQNIIKQKLGKAEQDKFLQGLEEKYKIPRDRYRVFAYWARGNHQNSTLLPRKFVVLEKAIALDGRDMRDARPSFENNSFGYIVSFTLTSSGAEKFFEITSQNKGRNLAIVWGDKVVSAPTIRSAIAGGVAQIDGSFTKEEAVDLANVISEGALPIPLRVLEMRFIGPTLGIESIEVGMKAVLIGFVLVMFYMILIYRLSGLVANAALFANIVILSALLSLMGFTLTLPGFAGIILTVGMAVDANVIIYERIKEELRAGKSATVAVAQGFDNAFWTIIDSNVTTLISGILMIRLGNGPIKGFAITLCWGIITSLFTSLFLSRLVMDLLVNRLGVQKLQLGFKKLES
>NZ_CP048830.1|WP_000459252.1|3076138_3077077_-|protein-translocase-subunit-SecF
MFDFIKYKYVSICISLALIVFGFSYTYAVHGGFANSLDFNGGLRTVVEFDQNMDRKKLENYFAENKIEAVLLLLDKEKHHYQIDIGLGSVDSILLKYREKNGLKPTDKVELSGIDALISILIADFRIDKSNILSANQVGAIVGGELSSTGTTLLGLTMAIILAYISFRFQFKFALGAILALTHDLILTVAFIGFFQIKPSVPIIAALLTLLGYSINDTIVVFDRIRENSAGNLNQTFGQTINSAINQTLGRTFNTSFATLISIVAIIIGGATELFDFAYVLTFGIVIGTYSSIFIAAPLVDIYDQVIRKARD
>NZ_CP048830.1|WP_001001361.1|3087942_3088374_-|ATP-binding-protein
MNEEKSLILLRGLPGAGKSRLAKLLSENGKYPVFSVDDYFTDSKTQEYNFDYKKNHLAYKHCEDCVRKEAERGTSKIFSDNTFTLSWEMEPYFQIASEFEYTIFVITVENYHNGKNVHSIDDESLKKMASKYKIRLLPEILSE
>NZ_CP048830.1|WP_000876121.1|3088473_3088716_+|hypothetical-protein
MKYLETEQIIPSKGMSYTMYEVEGEDQIQKMMTYIPNTDEIHIYPKPPVKKLYKPELCKVIDEVVFSELWKLGEERKAAK
>NZ_CP048830.1|WP_000493050.1|3088894_3089560_+|protein-L-isoaspartate-O-methyltransferase
MFSSSKVCNPILREQERKNMVDLQIASRGIRDKKILSAMLSIPRECFVPNSHILQAYEDKPLPIGCNQTISQPFMVAWMSLLLEVRKGDRIFEIGTGSGYQSAVLIFLEATLYSVEFFDSLSKTATQNLECWNPGCTQTNRFMIGSATEILKPELQFDKMISCAALPNLPDTKSSYFQSLIPGGIFIFPMGKRDQYLIFAKRNLNDWSFESKGGVRFVPLL
>NZ_CP048830.1|WP_000971361.1|3089587_3089794_-|hypothetical-protein
MMFLDFSSRCLNSVFLGFNRSIVVHPKVDSVSTCSFSKIEKYLKKIKRILSTISKILYLAKANIQKYF
>NZ_CP048830.1|WP_000365024.1|3089729_3091430_+|acyl-CoA-dehydrogenase
MDLLNPKKTEFKHLDEKSRNIMKRTIAFFEKKGKNKLKEDDRNQTWYADFLEFQKSEKIFATLMTPSGYGENDSRWDTTRICDFNEIAGFYGLCYWYTWQVSMLGLGPIWNSKNEEIKHKTAKLLLDGEIFAFGLSEKEHGADLISSDMSLENKGNGNYIANGRKYYIGNSNKAAIVSTFGKMKDTGNYVFFAVNSGHKNYELIQNVVNSQSYVGEYALKDYPISEKEILSKDREAWDASLSTIAVCKYNLGWASIGICTHSFYEALNHASKRKLFNRNVTDFSQIKQMFVDAYCRLFSMKLFAARAKDYMRSASATDRRYLLFNPMVKMKVTMQGEEVINLLWDVIAAKGFEKNMYFEMAAKDIRGLPKLEGTAHVNMALIIKFMNNYFFEPNSSLPVVPKIDDFKNDDFLFNQGTTSKGFEKITFRDYNEVYSNIDLPNVQIFRKQIAVLKEFLKSTPPDSKQSKDLDFMLILGELFTLVAYGQLLIENAAIEKVDNDLLDQIFDFMVRDCSKYALQLYSKRSSTKEQMEKCLAMIFKPAENEELFNRVCAKVYSYKDAYEMAP
>NZ_CP048830.1|WP_000377368.1|3091570_3092290_+|DNA-alkylation-repair-protein
MDSIRSKKEIKLILSKLSDSDESLWIFIIESELLKKKIKFPLLEFVGKELYFKIPEMNQIYFTDQIIKLGHMGSYVISAIILQLRMEKHFEQSLNKAVEYILLGNEWYVCDIIGERIMGYFLLKEPEKTLPILKNYINDKNGWIVRSVGVASHYAVKKGLGKKYVEVTFYLLLSKTDTKDFHTKKGIGWALKTISKFYPDIIQKFESNLLANPSIQPFFRKKIEIGLSRSSKYGSKYSD
>NZ_CP048830.1|WP_000079210.1|3092267_3093170_+|radical-SAM-protein
MAQSIRIKNILNKTKRRDPWFLDDYTINPYSGCSFRCLYCYVKGSKYGLNVEDKLSIKENAVEILDKQLSNLAKKNRHGIIVLSSATDPYLQLEKERGLTRELLKIILKYKFPVHILTKSDLILRDLDLLSEIEKNAILPVDLQNQLSRKSFITFSFSILDDSIAKIFEPGATSPSLRISALKETLKEGFFSGVSLMPLLPHISDTGENLEFMFQTFQEIGIRYIFPASLTLFGGNDPLDHKNLIFKAIENHFPHLLSKYQKFFSKNFRMPNFYQNALYHKTSELCSKYGLQKGILTTEF
>NZ_CP048830.1|WP_000421034.1|3094496_3095516_-|4-phosphoerythronate-dehydrogenase
MELKKPILYYPEGTIGAKEIFSSFEKLEVRSYPNDQIREISRDEPTILIANTRFQVNRDNIQNFPTVKIFATVSSGTDHVDFNALKEFKKIFLNAPGCNAGSVAEYCFAGLLNRFKESELKGLKIGLVGHGHTGKEFYKILISKGVNCIFYDPFYKTESRPLSEVLDASVLSFHVPLTKDGPEPTFRFVSTSLIDSLKSGTIFINTSRGEILSREAFNRLIARNDIFKILDVFDPEPPTLEMGRKLSEVKHSILTPHVAGYSQLGRIGGTYRVAEKLSILYQDKPLPPLNFFLQTSGEFKTSTFLKEEDRLLREAWRNGDTNYFEKRRNTYPIRLDWDF
>NZ_CP048830.1|WP_000854852.1|3095601_3096636_+|hypothetical-protein
MKTLQQKITFPILVGLISVTLIMLIWFVFFSGSKITTSSSASLDPESSSGSEGWILNQAIINTSRKIFDENGNWLSFDELIQYASNGEINLISELSDLRRQCPENIHYEQCNEIIRAFIADHYFGKDAEYLMKLFSSYLKYETKMKELEISYKLSRAEKYELIKKQRREFFSDKDTKLIFGLEEAEETYLDSLGGFLKDTETLSGEQRMQKYEEFRKNVYGQYYNTIKKREPKYNTYETEMFLREKELERMSSSERNSKTRHIREKYFGKDGADRMETVYQESEEKEKKEKQTAQEESDWIRKNPNVKVETKEKALMEIRIKNLGKEEAEEYSRRLKYEEEIKK
>NZ_CP048830.1|WP_000499626.1|3096642_3098373_+|apolipoprotein-N-acyltransferase
MFYNFISKDSILYRLILCFGIGIGTVFGLSPFSFFSAGVFASISCIFLFFSLNRTSIWKAFLWLLILSQILNFTAFYWIPGAISRISGANTFVSILFFFLYGLISHLKFFLFYTLFRFSKIDSASKTYILLIFPAAGTLSDMITFQIFPWYWGNLISGSIVFEQFASICGVYGLSFLLLFISSTFLILVNYYKYKNSKEFKTSIASLICIAFIYRFGLYRIGYINQSQNELKPKNLSVLMIQPDTSPGTKDLKADASYLSATMSKVFSLAIPTFENSPSLIVIPESAIPFHGTIDSEENRKEKIYSSTMEGIILYLSKHTGADVLFNELNLDENKLRNQVSLFKNLDGKTERYNKRRLLPFGEYLPMEKNFPFLRSIFQETSRYVPGEFPKLLIGNKIQNQRSFLPPEISKLNEPKTYRYEFSSIVEHTNKIRNLEYSYSILPLLCYEAMFTELVLDYFQNEQKPEVLINITNDSWFDSELEAYQHSGAVRLRAIETGLPLIRSAVSGISEVWDARGIPMIVPIGFHETGTRAFSIRLDAIESTIYTRFGNSFLWIFCILILISRLIFVSRIERKS

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Crispr_ID: NZ_CP048830_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048830_10

3391124-3391225

Orphan

Consensus_repeat	Method
CTGACAAATTCTAAGTTGTAAGAGTTCCCACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP048830_10

>merge|NZ_CP048830|10|3391124-3391225|CRISPRCasFinder
CTGACAAATTCTAAGTTGTAAGAGTTCCCACAAATTCAAAACCTGGATGTAGTTCCGACCCAAAGTTCAACTGACAAATTCTAAGTTGTGAGAGTTCCCACA

>NZ_CP048830|10|10|3391124-3391225|CRISPRCasFinder
CTGACAAATTCTAAGTTGTAAGAGTTCCCACA	AATTCAAAACCTGGATGTAGTTCCGACCCAAAGTTCAA
CTGACAAATTCTAAGTTGTGAGAGTTCCCACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048830.1\|WP_000981017.1\|3396122_3396371_+\|DUF1563-domain-containing-protein	unknown	unknown	gnl\|CDD\|203693
NZ_CP048830.1\|WP_000940600.1\|3380696_3380951_-\|50S-ribosomal-protein-L27	unknown	unknown	gnl\|CDD\|235464
NZ_CP048830.1\|WP_000403254.1\|3385848_3386745_-\|hydroxymethylglutaryl-CoA-lyase	unknown	unknown	gnl\|CDD\|163676
NZ_CP048830.1\|WP_000622607.1\|3389830_3390892_-\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	unknown	unknown	gnl\|CDD\|172940
NZ_CP048830.1\|WP_001181792.1\|3399855_3400614_-\|biotin--[acetyl-CoA-carboxylase]-ligase	unknown	unknown	gnl\|CDD\|223417
NZ_CP048830.1\|WP_000092385.1\|3396556_3398452_+\|DUF1561-domain-containing-protein	unknown	unknown	gnl\|CDD\|284921
NZ_CP048830.1\|WP_000443450.1\|3379511_3380582_-\|GTPase-ObgE	unknown	unknown	gnl\|CDD\|237048
NZ_CP048830.1\|WP_000270913.1\|3381263_3381578_-\|50S-ribosomal-protein-L21	unknown	unknown	gnl\|CDD\|235510
NZ_CP048830.1\|WP_000778965.1\|3402324_3403650_-\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383
NZ_CP048830.1\|WP_000559672.1\|3403686_3404547_-\|acyl-[acyl-carrier-protein]-thioesterase	unknown	unknown	gnl\|CDD\|238329
NZ_CP048830.1\|WP_001082135.1\|3384937_3385852_-\|TIGR02757-family-protein	unknown	unknown	gnl\|CDD\|378237
NZ_CP048830.1\|WP_000619383.1\|3380940_3381267_-\|ribosomal-processing-cysteine-protease-Prp	unknown	unknown	gnl\|CDD\|184740
NZ_CP048830.1\|WP_000671558.1\|3393162_3394554_+\|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase	unknown	unknown	gnl\|CDD\|223842
NZ_CP048830.1\|WP_001071951.1\|3387764_3389501_-\|glycosyltransferase-family-39-protein	unknown	unknown	gnl\|CDD\|224720
NZ_CP048830.1\|WP_000099241.1\|3391982_3392741_-\|indole-3-glycerol-phosphate-synthase	unknown	unknown	gnl\|CDD\|140013
NZ_CP048830.1\|WP_001169645.1\|3384012_3384873_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|226383
NZ_CP048830.1\|WP_000928025.1\|3399080_3399854_-\|type-III-pantothenate-kinase	unknown	unknown	gnl\|CDD\|237347
NZ_CP048830.1\|WP_001068430.1\|3389515_3389800_-\|Cys-rich-protein	unknown	unknown	gnl\|CDD\|275246
NZ_CP048830.1\|WP_000468132.1\|3401713_3402229_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000884017.1\|3392747_3393080_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914

Protein	Function_ID	Function_description	E-value
NZ_CP048830.1\|WP_000981017.1\|3396122_3396371_+\|DUF1563-domain-containing-protein	gnl\|CDD\|203693	pfam07599, DUF1563, Protein of unknown function (DUF1563). A small family of short hypothetical proteins in Leptospira interrogans.	3.94011e-16
NZ_CP048830.1\|WP_000940600.1\|3380696_3380951_-\|50S-ribosomal-protein-L27	gnl\|CDD\|235464	PRK05435, rpmA, 50S ribosomal protein L27; Validated.	1.63848e-52
NZ_CP048830.1\|WP_000403254.1\|3385848_3386745_-\|hydroxymethylglutaryl-CoA-lyase	gnl\|CDD\|163676	cd07938, DRE_TIM_HMGL, 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain. 3-hydroxy-3-methylglutaryl-CoA lyase (HMGL) catalyzes the cleavage of HMG-CoA to acetyl-CoA and acetoacetate, one of the terminal steps in ketone body generation and leucine degradation, and is a key enzyme in the pathway that supplies metabolic fuel to extrahepatic tissues. Mutations in HMGL cause a human autosomal recessive disorder called primary metabolic aciduria that affects ketogenesis and leucine catabolism and can be fatal due to an inability to tolerate hypoglycemia. HMGL has a TIM barrel domain with a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. The cleavage of HMG-CoA requires the presence of a divalent cation like Mg2+ or Mn2+, and the reaction is thought to involve general acid/base catalysis. This family belongs to the DRE-TIM metallolyase superfamily. DRE-TIM metallolyases include 2-isopropylmalate synthase (IPMS), alpha-isopropylmalate synthase (LeuA), 3-hydroxy-3-methylglutaryl-CoA lyase, homocitrate synthase, citramalate synthase, 4-hydroxy-2-oxovalerate aldolase, re-citrate synthase, transcarboxylase 5S, pyruvate carboxylase, AksA, and FrbC. These members all share a conserved triose-phosphate isomerase (TIM) barrel domain consisting of a core beta(8)-alpha(8) motif with the eight parallel beta strands forming an enclosed barrel surrounded by eight alpha helices. The domain has a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. In addition, the catalytic site includes three invariant residues - an aspartate (D), an arginine (R), and a glutamate (E) - which is the basis for the domain name "DRE-TIM".	2.57982e-157
NZ_CP048830.1\|WP_000622607.1\|3389830_3390892_-\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	gnl\|CDD\|172940	PRK14465, PRK14465, 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN.	0
NZ_CP048830.1\|WP_001181792.1\|3399855_3400614_-\|biotin--[acetyl-CoA-carboxylase]-ligase	gnl\|CDD\|223417	COG0340, BirA, Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism].	2.12937e-35
NZ_CP048830.1\|WP_000092385.1\|3396556_3398452_+\|DUF1561-domain-containing-protein	gnl\|CDD\|284921	pfam07598, DUF1561, Protein of unknown function (DUF1561). A family of paralogous proteins in Leptospira interrogans.	0
NZ_CP048830.1\|WP_000443450.1\|3379511_3380582_-\|GTPase-ObgE	gnl\|CDD\|237048	PRK12299, obgE, GTPase CgtA; Reviewed.	1.53712e-180
NZ_CP048830.1\|WP_000270913.1\|3381263_3381578_-\|50S-ribosomal-protein-L21	gnl\|CDD\|235510	PRK05573, rplU, 50S ribosomal protein L21; Validated.	3.64764e-32
NZ_CP048830.1\|WP_000778965.1\|3402324_3403650_-\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	2.29061e-112
NZ_CP048830.1\|WP_000559672.1\|3403686_3404547_-\|acyl-[acyl-carrier-protein]-thioesterase	gnl\|CDD\|238329	cd00586, 4HBT, 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites. There is no evidence to suggest that 4HBT is related to the type I thioesterases functioning in primary or secondary metabolic pathways. Each subunit of the 4HBT tetramer adopts a so-called hot-dog fold similar to those of beta-hydroxydecanoyl-ACP dehydratase, (R)-specific enoyl-CoA hydratase, and type II, thioesterase (TEII).	1.14607e-10
NZ_CP048830.1\|WP_001082135.1\|3384937_3385852_-\|TIGR02757-family-protein	gnl\|CDD\|378237	pfam09674, DUF2400, Protein of unknown function (DUF2400). Members of this uncharacterized protein family are found sporadically, so far only among spirochetes, epsilon and delta proteobacteria, and Bacteroides. The function is unknown and its gene neighborhoods show little conservation.	6.52672e-90
NZ_CP048830.1\|WP_000619383.1\|3380940_3381267_-\|ribosomal-processing-cysteine-protease-Prp	gnl\|CDD\|184740	PRK14553, PRK14553, ribosomal-processing cysteine protease Prp.	1.13544e-27
NZ_CP048830.1\|WP_000671558.1\|3393162_3394554_+\|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase	gnl\|CDD\|223842	COG0771, MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane].	1.35745e-117
NZ_CP048830.1\|WP_001071951.1\|3387764_3389501_-\|glycosyltransferase-family-39-protein	gnl\|CDD\|224720	COG1807, ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane].	4.32075e-40
NZ_CP048830.1\|WP_000099241.1\|3391982_3392741_-\|indole-3-glycerol-phosphate-synthase	gnl\|CDD\|140013	PRK13957, PRK13957, indole-3-glycerol-phosphate synthase; Provisional.	3.07092e-171
NZ_CP048830.1\|WP_001169645.1\|3384012_3384873_-\|VOC-family-protein	gnl\|CDD\|226383	COG3865, COG3865, Uncharacterized protein conserved in bacteria [Function unknown].	7.00265e-54
NZ_CP048830.1\|WP_000928025.1\|3399080_3399854_-\|type-III-pantothenate-kinase	gnl\|CDD\|237347	PRK13318, PRK13318, type III pantothenate kinase.	3.31134e-115
NZ_CP048830.1\|WP_001068430.1\|3389515_3389800_-\|Cys-rich-protein	gnl\|CDD\|275246	TIGR04453, Lepto_8Cys, Cys-rich protein, LA_1312 family. Members of this protein family occur, so far, exclusively in the genus Leptospira. Members, although small (about 90 amino acids), have a predicted signal peptide followed by a region with eight invariant Cys residues. Some members have an additional Cys in the signal peptide region that suggests handling as a lipoprotein, but this Cys is not well conserved.	5.08556e-29
NZ_CP048830.1\|WP_000884017.1\|3392747_3393080_-\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	4.75168e-26

>NZ_CP048830.1|WP_000622607.1|3389830_3390892_-|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN
MISENLGENQTEKIPLKGRTLKELSEIMITLGEKPFRAKQIYHGLYVNRYETWDQFTTFSKIFKEKLEELCSLTHLQVVKQLKSVDGTQKFTFTSESGNGKEFEAVWIPSGDGGRKTICISSQIGCTLNCKFCATAKLEFQGNLKAHEIVDQILQVEKIVGDKATNVVFMGMGEPLHNYFNVIRAASIFHDPDALNLGAKRITISTSGVVNGIRRFIENKEPYNFAISLNHPDPKGRLQIMDIEEKFSLPELLQAAKDFTRELKRRITFEYVMIPGVNMGFENANKLVKIAKSLDCKINVIPLNTEFFGWRRPTREEIAEFIALLEPAGVPILNRRSPGKDIFGACGMLASKS
>NZ_CP048830.1|WP_001068430.1|3389515_3389800_-|Cys-rich-protein
MNPKRTIILFLYLLPFVSCQEYVQQKCNSACKFFVQCAMNDFKHVKVTELEKNQMMIDCESGCIREQGFVLPCFESETTCKGFNTCVMESGFMD
>NZ_CP048830.1|WP_001071951.1|3387764_3389501_-|glycosyltransferase-family-39-protein
MNQISVDNKQPISVWILFIFLIVSVLPLILTLPLDMIDIDSSQYAEISREMVEGGNPFFIRDNGRRYLDKPILTFWKISLSFLIFGYQNFAFRLPALLFTFFSFWGIFKLTELYSESRLRAWISVFLYALSPGLYSMVVDPKIDVYLTPYLILVHTFYYLGFKRNQNYYYLMYFAMGLGFITKGPIAMVIPSISIGGDILFRRDWRRLLEMKLFPGVLLAILPPLLWSIPLYLEFQTYGPYFFLWIQSFGRFYVKMYNQKFNPLFFYSNFSWAFGVFILPFFGFVFDRIVTFLKQNKGKEVFQNILKNKYFNLDFVIGFWLFLFLFLISFSRYQLPQYIYWCLPAAAVIGSGVLESILLSLKDQKNKSWFNKLNQGLLLVTAVVFLIAVLVIPWISVEVGWSYLILPLAYLGVFLWVFFKSSTIGRLLAFWIFSASLFFSIVSLYLYPMLTSFQPSKEIGIWIRKYEPNKDKLFLFGVPASKRSYAYYSKRISRTLFDPAVLIDSVQKDGQRYLIVQDKWLPKLEEFFGNNLQFETVKEFPSYKVATPEGKFFLKSHRDQIVGKVILMRASRKDFQKK
>NZ_CP048830.1|WP_000403254.1|3385848_3386745_-|hydroxymethylglutaryl-CoA-lyase
MEIKITEVGPRDGLQNEKSPVSTEVKAEFIQRLVRAGLKNIEATSFVKKDSIPQLADATELSAFLDLNGSVSFSALTPNLKGYEAAKSAGYKEVAVFTAASESFTKKNINRTISESIEGFKDIFNFSKIDGIQVRGYVSTVIDCPYEGKMNPKKVLEVSKILLDLGAYEISLGETIGTGVPTEVEKLLEVLLKEIPANKLAGHFHDTYGMAIANVEKAYSMGLRSFDSSAGGLGGCPYAKGAAGNLATDDLVYFLEKSGISTGIDPNLLWEASLFMEKSLSRELQSRTFLATKKKRES
>NZ_CP048830.1|WP_001082135.1|3384937_3385852_-|TIGR02757-family-protein
MNRSSQKIKRVLENLFLEYQTSDYLRSDPVEFPHLFSDLRDREISGFISALFSYGNITAIKDHLKRIFAICGNSPYRFLLNEDLKSIRKNLKSYRFQKPEDTYLFLQTIQNKLRTTEGHGLESLFSLPEEGEFQFSSRDQKSFLEGGSLRRRILSFQLRFLKESSKIDSKQTKSYGYKFLVGQGIRSTSLKRYSMFLRWMVRKEFPDFGIYSSISPSELQFPLDVHIQRIASVLNLSSRRSSDWKKAEEVTDFFRAIFPDDPVKADFALSRLGILKKCKSKYLRELCESCGIRSICKVYEGFSK
>NZ_CP048830.1|WP_001169645.1|3384012_3384873_-|VOC-family-protein
MQKITPFLMFDNNLGEALKLYASTFSDWKLLSQNQTGDVVMSATFAISGKEILSFNGGPHFKFTPAISFFLSCQTSKEIEKIWASLSQEGIVLMELQEYPFSEKFGWVQDKFGVSWQVCLSKEGNDLVTFLMFVGKQHGKAEEAIRFYTSQFPNSKINDIQRYTTDQSEKEGTVQRSVFSIAGQDLMAMDSGLDHAFTFSEAYSFFIKCETQAEIDKYWEKLSFQGEKQKCGWVKDKFGVSWQIIPSILGDYLQDKDPKKSQRVLQAMLQMDKIDIVKLKRAYDSN
>NZ_CP048830.1|WP_000270913.1|3381263_3381578_-|50S-ribosomal-protein-L21
MYAIISVGNRQYKVTQDQEFLTEKTGKNAGESFDAKVLLFAESNNKVHIGQPELKTARVSLKVLEDVKGDKIHGYVYKRRKNYQKAWGHRQQLQKVKVVSLSAV
>NZ_CP048830.1|WP_000619383.1|3380940_3381267_-|ribosomal-processing-cysteine-protease-Prp
MIRIRITRTGEFYSSLETEGHSSVSLGKKGENLLCSAVSVLVQTLYLYLLQSGKTKPAEVRDGYLRFEVLEQDVLIQNSFDLVLSGLKNLKNQYPTEIELIGVPENGT
>NZ_CP048830.1|WP_000940600.1|3380696_3380951_-|50S-ribosomal-protein-L27
MAHKKGGGSSKNGRDSNSQRLGVKRFGGESVLAGNILVRQRGTKFRPGNNVGLGKDHTLFALVTGKVKFEMVTKLKMQVSVYPE
>NZ_CP048830.1|WP_000443450.1|3379511_3380582_-|GTPase-ObgE
MESFVDEVAIEVFAGHGGAGSVHFRREKYVEFGGPDGGDGGIGGNVVIRPNLSMYTLDKYLSKRKFKAQAGFPGVGDNCSGKKGEDLVLFVPLGTQIYDEETGDLLFDFVSDSQEFVVARGGRGGKGNAHFKTSTNQTPRFAQPGEEGEYKFLRLSLKLLADVGIVGLPNAGKSTLISKITDAHPKIAGYAFTTLSPNLGVVKRRGDIFRFTIADIPGIIEGASMGIGLGLSFLRHIERVKGILYLFDASSLDIEEDLKMLRNELSTYNPELLNRPYLIVLNKIDIWNDPEFTKDVIAKVSHLGKVVAISADQEVNLEELLENMDEVFFKNEIEKILNPIKDTKPISLDESDIFES
>NZ_CP048830.1|WP_000099241.1|3391982_3392741_-|indole-3-glycerol-phosphate-synthase
MSSSQPHRVLREIISTKQNEIKKISAWDPLPHRGLSLRDSLKSRTFSIIAECKRKSPSAGELRADYRPVQIAKTYEELGASAISVLTDQNYFGGSLEDLKDVSSELKIPVLRKDFILDEIQIREARAFGASAILLIVRILTPEQIKSFLKLASSLGMDCLVEVHTSDEAKLALDCGAEIIGINTRDLDTFQIHQNLVEEVSAFLPPNIVKVGESGIKKRSDLDTFRKLVDAALIGTYFMEKQDIRKAWLNLF
>NZ_CP048830.1|WP_000884017.1|3392747_3393080_-|STAS-domain-containing-protein
MLDHKVRDGVLIVYLKGRLDVSIANEVEENLNDLIDNQGHKKVILNMQEVDYMSSSGFRACISTLRKLNSKEGALKISNIKPAVKRIFDVIELTSLFDICETEDEALKSF
>NZ_CP048830.1|WP_000671558.1|3393162_3394554_+|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase
MKFPESLKGLKILVLGGGISGNSALNFLISEKAQPILCDRNQPERTVVPFFPDNIPPQSLPEVSLVIKSPGILPTHPILSYAADKKIPVVSEIDLGRYFFKGKIIGITGTDGKSTTTSLIAHLLKESFPDLKEGGNLGIPFTSFCKESISLAVLELSSYQLEDSSPLHLDVSVFLNLASDHLERHKTMENYFQAKLKIADLSNSNHTLIVSEKIKERILNSISYQCKLLSFGKTSDSNAFLDENSLKIKTSKFVYDISKFYLPGTHNRENLAASILAAEEIGGKPESIQTRIPLFRGLPHRFQIAGEKLGISFINDSKSTNLHSMLAGMATWKNIDQTCLILGGRPKQEDLKPLYNFLIKGIGCVVLFGEARATWESGIKNIIGEKLYCVENLNDTFEIFKKGNIFPVPGLNKDIIIRLSDSISISSFVFSPACASFDQYKNFEERGNHFLSLVNDFLDQIDS
>NZ_CP048830.1|WP_000981017.1|3396122_3396371_+|DUF1563-domain-containing-protein
MMNIILIGFFLLETLENLYTAYVEYFLKQTFLDSIQKISKTDRKQNEIPVLPIFKILIFQVISSKGIFLSLSDNKINQRYKL
>NZ_CP048830.1|WP_000092385.1|3396556_3398452_+|DUF1561-domain-containing-protein
MSRWIVLLLVLLISLGVGYSYGVNPDVVPISSNDIPSSIIQRPTDKPKDKPIKIVIHDGGTFCYGPTFSGGESYIVIEQCWQMNVMNARYDVFQRISYNINNTWLCITVPESVVKGETNWDYVHLRPCTINDPLQRWIVKDNSFWTADKRYRLKDYNWYAYISKNSGDRYNHTLDSSMSDWINTVATPGNISILTSIAWNLGSDRYFIRSGGSDKNTTPIYYNPESGHLAQYNPVSGSLYCMYSRVGSYNWNWVTWALCSDAPISKDNPAFWNVSYETEEGGMIMDYQGNALRVARYGPNWGVAYAVKLSYLKKDTTYNPTSLFIVDRNLLNWVRYTASNLGKTDQYCPAGKKESRAKRVKRTLPSDFQLTEEWIQRLYDIAISTVTNPQVSGICGVCLLQTFQILAELQEYHSREPLQSGGYFFDTAPNRDPFISFRQRYPELDSLLSHIPRVYNSDSTTLRLLTLVSAMNMMPLYDWTPSREFTTRSEILSHITSLIDSPAGSIWLALMRRQRPDGTIAGHSVPILRTSEGLVVIPTRVPSSISLELYREYLTPTMDPIQAINNLEQPDRTLTYFVTIQLGEFYDNFTDLVISNRNCTGEGEGRRGTGEYPASATVNQCSESRCALPSQ
>NZ_CP048830.1|WP_000928025.1|3399080_3399854_-|type-III-pantothenate-kinase
MLLVVDVGNTNTVFGIFENGNKIPLFHKRTVTRKDRTSDELGLFFRGFLREFKIENEMITGGIYSSVVPTLNPILDRMFQDWFKIEAIRVHYQMKLPFSISYPRPYEIGADRLVNAATCAIDFPGKSIIIDLGTATTFCVVNEKPEYLGGVIAPGLKVSMDALTRNTSQLPPIVFQSPGKILGDSTIESIQAGFFFGWIGLLEGIIREIKKDKGQDYQVIGTGGLVTVIDAAHPGIFDKIDPLLTLRGLQILHLMNS
>NZ_CP048830.1|WP_001181792.1|3399855_3400614_-|biotin--[acetyl-CoA-carboxylase]-ligase
MQNVLLQPEKGIFLDSVTSTNTVIKGKEFPHGTWIVAEEQTAGRGRKDRTWEVFGEESLIFSGKIGLENFDAGPGLSLFIGTAVCKTILSVYPELTREIKIKWPNDLYRGNKKVAGILIESEIEGSFMTLIIGVGLNLYGKNESIPNHLTDAGFLNTNPNRAGKKNEILEKLVPFLNESILLWKDIEGRKKELILLNELLLWKGQSVRYKENGQLQTGILEGLSENGSLILKTPSGTRLDFIDSPEDFHSLN
>NZ_CP048830.1|WP_000468132.1|3401713_3402229_-|hypothetical-protein
MFGVFLEYELQDVFRVFVQLDAEELELTDTVVFSFDVGFFQLHVDVHKKFLRRMCSANDIVIEGDYHDQTGVQLRTFGIISHPFRVGAIHVIFEVIDVQQYPVGIFLATEQRKLALGINFHLDDVEVGVPEMLWTYVCGLVPNSRSIVVKRYYNQVQGFELLQTLRFYSDT
>NZ_CP048830.1|WP_000778965.1|3402324_3403650_-|thiolase-family-protein
MKLTKPLAICTPRRTPFAQIAKALGPYPGHHLGKIVAEDILAKSKLKPSQIDGVVVGEGFSNAPNSARVIANLVGMRDEIACITVANNCVSGMEAVAEAARRIVLGEGEVFLAIGEESQTSMPFVVKNARLNKKAGSLDKLKKLLPDNLPEGVELRDTLEDGLGDGETSYGMQVTAEIVAQNYGLSREIQDKLAFESFKRALEASKAGKYSPYIIPMKDDEGNELTIDEAVGLREGLVENPTRMGRAMLMFDNPGMKFEEFKTKYSKDLKKSHGPTVSIFNASPRSDGAAGVIVTTVEKAKELGLTIEAVVSGWHMKGVHPNNMGIGQAVATKALLDETGIKIQDVDYVEIHEAFAATAVGALEQIKMDTGWDWEKSFDAKKINPNGGSIAIGHPFGATGIRLIANAIMDLKEDSSANKVLITACAHGGIAGSMLIERYKG
>NZ_CP048830.1|WP_000559672.1|3403686_3404547_-|acyl-[acyl-carrier-protein]-thioesterase
MIADEIQLVTRISDLDTQRHVTSRTYENFCLEGRFRTLEKNGFSIREILSQGIKIHPLESQIRFLAQQMEGASLKTETKAFPLKDGKIFWDQKVLSDTGTIAAEIKTLTFSEKDGHPIDLLPLEKTEMSGFDQFPQIPDFRGTCKTVDTSMITLYSERNIFGEYNPAYLWRIVEDSRWFFSTETGLTLDRFVEMDTTLFFMGGVFRFFHPVPAGRKIKVSTWIHSFEKIRSYMRHEVTDIETGLRYFAVQDEQLVVSLTKSRPKKAPDEFQQLVGDYVENFEYSKK

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Crispr_ID: NZ_CP048830_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048830_11

3994748-3994843

Orphan

Consensus_repeat	Method
AGGAAAGCGTTGTGTTGAGTTTTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP048830_11

>merge|NZ_CP048830|11|3994748-3994843|CRISPRCasFinder
AGGAAAGCGTTGTGTTGAGTTTTCCAACGCGACCTGCAGAGCGACCCTTAGGGAGCGATGCATTGAGTTTGAGGAAAGCGTTGTGTTGAGTTTCCC

>NZ_CP048830|11|11|3994748-3994843|CRISPRCasFinder
AGGAAAGCGTTGTGTTGAGTTTTCC	AACGCGACCTGCAGAGCGACCCTTAGGGAGCGATGCATTGAGTTTG
AGGAAAGCGTTGTGTTGAGTTTCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048830.1\|WP_042709723.1\|3990119_3991907_-\|apolipoprotein-N-acyltransferase	unknown	unknown	gnl\|CDD\|234721
NZ_CP048830.1\|WP_000801153.1\|3995729_3996218_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000776815.1\|4000795_4001578_-\|PhzF-family-phenazine-biosynthesis-protein	unknown	unknown	gnl\|CDD\|223461
NZ_CP048830.1\|WP_000931455.1\|3989482_3989971_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379725
NZ_CP048830.1\|WP_162839745.1\|4002326_4002470_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000181227.1\|3998604_3998931_-\|(2Fe-2S)-ferredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|239278
NZ_CP048830.1\|WP_000696002.1\|3986981_3988376_-\|DUF1554-domain-containing-protein	unknown	unknown	gnl\|CDD\|369437
NZ_CP048830.1\|WP_000086941.1\|4002630_4004103_-\|amidophosphoribosyltransferase	unknown	unknown	gnl\|CDD\|236384
NZ_CP048830.1\|WP_001257925.1\|3992157_3993456_+\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|236486
NZ_CP048830.1\|WP_000798179.1\|3997029_3997581_-\|LEA-type-2-family-protein	unknown	unknown	gnl\|CDD\|377000
NZ_CP048830.1\|WP_000250245.1\|3996227_3996563_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_011172394.1\|3984973_3985393_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_001053085.1\|3997585_3998608_-\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176251
NZ_CP048830.1\|WP_001983916.1\|3984109_3984685_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_000264550.1\|3999797_4000787_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371795
NZ_CP048830.1\|WP_001080168.1\|3993452_3994109_+\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|319895
NZ_CP048830.1\|WP_000468940.1\|3985424_3986540_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048830.1\|WP_002145703.1\|3999351_3999819_+\|DUF3347-domain-containing-protein	unknown	unknown	gnl\|CDD\|378730
NZ_CP048830.1\|WP_001062719.1\|3982844_3984041_-\|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl\|CDD\|236226
NZ_CP048830.1\|WP_000682546.1\|3994150_3994522_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP048830.1\|WP_042709723.1\|3990119_3991907_-\|apolipoprotein-N-acyltransferase	gnl\|CDD\|234721	PRK00302, lnt, apolipoprotein N-acyltransferase; Reviewed.	4.06739e-69
NZ_CP048830.1\|WP_001053085.1\|3997585_3998608_-\|zinc-binding-dehydrogenase	gnl\|CDD\|176251	cd08291, ETR_like_1, 2-enoyl thioester reductase (ETR) like proteins, child 1. 2-enoyl thioester reductase (ETR) like proteins. ETR catalyzes the NADPH-dependent conversion of trans-2-enoyl acyl carrier protein/coenzyme A (ACP/CoA) to acyl-(ACP/CoA) in fatty acid synthesis. 2-enoyl thioester reductase activity has been linked in Candida tropicalis as essential in maintaining mitiochondrial respiratory function. This ETR family is a part of the medium chain dehydrogenase/reductase family, but lack the zinc coordination sites characteristic of the 2-enoyl thioester reductase (ETR) like proteins. ETR catalyzes the NADPH-dependent dependent conversion of trans-2-enoyl acyl carrier protein/coenzyme A (ACP/CoA) to acyl-(ACP/CoA) in fatty acid synthesis. 2-enoyl thioester reductase activity has been linked in Candida tropicalis as essential in maintaining mitiochondrial respiratory function. This ETR family is a part of the medium chain dehydrogenase/reductase family, but lack the zinc coordination sites characteristic of the alcohol dehydrogenases in this family. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. Candida tropicalis enoyl thioester reductase (Etr1p) catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis. Etr1p forms homodimers, with each subunit containing a nucleotide-binding Rossmann fold domain and a catalytic domain.	1.91366e-154
NZ_CP048830.1\|WP_000776815.1\|4000795_4001578_-\|PhzF-family-phenazine-biosynthesis-protein	gnl\|CDD\|223461	COG0384, COG0384, Predicted epimerase, PhzC/PhzF homolog [General function prediction only].	7.4343e-73
NZ_CP048830.1\|WP_000931455.1\|3989482_3989971_-\|hypothetical-protein	gnl\|CDD\|379725	pfam15428, Imm26, Immunity protein 26. A predicted immunity protein with mostly all-beta fold and several conserved hydrophobic residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-URI1 or Tox-HNH family. The protein is also found heterogeneous poly-immunity loci.	7.28327e-21
NZ_CP048830.1\|WP_000798179.1\|3997029_3997581_-\|LEA-type-2-family-protein	gnl\|CDD\|377000	pfam03168, LEA_2, Late embryogenesis abundant protein. Different types of LEA proteins are expressed at different stages of late embryogenesis in higher plant seed embryos and under conditions of dehydration stress. The function of these proteins is unknown. This family represents a group of LEA proteins that appear to be distinct from those in pfam02987. The family DUF1511, pfam07427, has now been merged into this family.	4.75264e-09
NZ_CP048830.1\|WP_000086941.1\|4002630_4004103_-\|amidophosphoribosyltransferase	gnl\|CDD\|236384	PRK09123, PRK09123, amidophosphoribosyltransferase; Provisional.	0
NZ_CP048830.1\|WP_001257925.1\|3992157_3993456_+\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	gnl\|CDD\|236486	PRK09369, PRK09369, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated.	0
NZ_CP048830.1\|WP_001062719.1\|3982844_3984041_-\|NADP-dependent-isocitrate-dehydrogenase	gnl\|CDD\|236226	PRK08299, PRK08299, NADP-dependent isocitrate dehydrogenase.	0
NZ_CP048830.1\|WP_000181227.1\|3998604_3998931_-\|(2Fe-2S)-ferredoxin-domain-containing-protein	gnl\|CDD\|239278	cd02980, TRX_Fd_family, Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:ubiquinone oxidoreductase (NuoE). TRX-like Fds are soluble low-potential electron carriers containing a single [2Fe-2S] cluster. The exact role of TRX-like Fd is still unclear. It has been suggested that it may be involved in nitrogen fixation. Its homologous domains in large redox enzymes (such as Nuo and hydrogenases) function as electron carriers.	2.97611e-18
NZ_CP048830.1\|WP_000264550.1\|3999797_4000787_+\|hypothetical-protein	gnl\|CDD\|371795	pfam11916, Vac14_Fig4_bd, Vacuolar protein 14 C-terminal Fig4p binding. Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. The C-terminal region of Vac14 binds to Fig4p. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.	0.00388451
NZ_CP048830.1\|WP_001080168.1\|3993452_3994109_+\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|319895	cd16373, DMSOR_beta_like, uncharacterized subfamily of DMSO Reductase beta subunit family. This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.	2.25851e-38
NZ_CP048830.1\|WP_002145703.1\|3999351_3999819_+\|DUF3347-domain-containing-protein	gnl\|CDD\|378730	pfam11827, DUF3347, Protein of unknown function (DUF3347). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 169 to 570 amino acids in length.	1.00377e-06
NZ_CP048830.1\|WP_000696002.1\|3986981_3988376_-\|DUF1554-domain-containing-protein	gnl\|CDD\|369437	pfam07588, DUF1554, Protein of unknown function (DUF1554). A family of proteins identified in Leptospira interrogans.	1.94228e-40

>NZ_CP048830.1|WP_000682546.1|3994150_3994522_+|hypothetical-protein
MKHPLLFFLSVQFILSGLFAESNPKATPCSKDVENFCSHRKSEDRLSQMQCLMEKESDLSTTCSDWLKLKKEEIRKSSEECSEDRSKFCKFVIPGGGRILRCLMNHESSLSISCKEMIKRHLP
>NZ_CP048830.1|WP_001080168.1|3993452_3994109_+|4Fe-4S-dicluster-domain-containing-protein
MNRKDFFKKGLARMLDFAQENATELVSGFQEIVSKETPPPAPKKTNTKKVRKQTEFLLPEQIKSNRKRKIRNVQFPPGALDETEFLKKCTGCGDCIYACPYSVLFPVFEENLEKHIPRMDVNLNACMLCKDWPCINSCKTGALIPLEGAPKFGQAKGIFEYCINSKTGESTCSNCRDSCPIEGVVNFKGNKPSFSKNCTGCGQCVSACPTFPRAIRIK
>NZ_CP048830.1|WP_001257925.1|3992157_3993456_+|UDP-N-acetylglucosamine-1-carboxyvinyltransferase
MRSSYFKIIGKTPLHGTVVPQGNKNEALPLLGAVCMVPGTVRISNIPVISDVLMLMEVLRHLGMEITEEEPGTYIFKHDGNLKNQLPEELCSRIRGAVTLAGPILAMTGRVFLPKPGGDKIGRRRLDTHLLALQALGASIEVFPDGYEIKADQLKGTDILMDEASVTGTENAVMAAVFAEGTTILRHAASEPHVQRLCHFLNSAGAKISGIGSNILTIEGVTSLKPPAKEHKIGSDYLEVGSFISLAAVTGGELMIRDVELEDIRMIRMVYSRLGIEVRPHENGILVPSDQKMEIIPDYHGATPKIDDSPWPGFPADMTSVALVTATQCKGTVLIHEKMFESRLFFVDNIIAMGAQIILCDPHRAIVIGHSRLYGQKVASPDIRAGMAMIIAALCAEGTSYIHNIGQIDRGFENIDTRLRALGARIERVNAD
>NZ_CP048830.1|WP_042709723.1|3990119_3991907_-|apolipoprotein-N-acyltransferase
MDTLHHRFQQFQKTIWFNIFCYLWTGIFSFLAFAPVSLTHFVWIAPFGFFWLSLKYHGKYKKLFFHGLLIGVVFYAISFHWIIHMAITFGNFPYVVAILILLFAGLLFGLKFPIFMMSFSFLSGKIGRHSVWVAGFCGLLSELIGPQLFPWYWGNLAAGNIILAQNAEITGVYGISFLVFIVSYTLFQSNPWHWKEIIHSKEKRKQYLRFITLPALLLLTFIVSGIFLFKKWENVKPVKSLNVLIVQPDAPLSFRDGREIKESIEALMARIEKLTDEGAVRLGKKPDLIVLPEAGVPFFSAHKTEITTKVRRMYWDRFDSLMFLLANRYKANVFFNEIDAGFKGAPSPRNLRYYNNNVLYDPNGDRRDSYQKKFLLMFGEYMPFDFLYELSQQTGRFEPGLTHNLIRYYTPRYYTLAEKEKSPKGRHLGWTDTETFNHEAVRSYYETTRTEVSETGKFLPLICYEVILPEFVREFRTAGNPEFIVNLTNDKWYGATTESDQHMELGRLRSIELRRWMVRSTNSGISANIDHLGRFVGNKKTGLMTAEALSETIDVIDSPPTFYTQYGNLIPWLMLFLTGIYYLNLLIGIRRGKSS
>NZ_CP048830.1|WP_000931455.1|3989482_3989971_-|hypothetical-protein
MLNEVKYPFVPKSNRSLIPGQFWAIPLNNGKFACGRVIEVHPFETKMFLAGLVNWIGEVVPKENDLAGKQTIKQGQVHIKTIHETGSDGMIIGYRNLSLDKIEPDFFKSQDGYQSGTSKLMKGYQEIRPLTKDESDLYPTFSTWGYDVIRVLAEELSVSKKI
>NZ_CP048830.1|WP_000696002.1|3986981_3988376_-|DUF1554-domain-containing-protein
MKIKYKFAILSAFTLVFVACLNKSSGDDNAVLSGLISLISNEQGCVGLDCSKNRTLRSNQLQSGQSLQAAFPQGYLPYIYVTSVSGVGHNGNFGGIAGADAYCQSNIPGNLSPTGVYKAMLVDGVNRVATTVGPNSTVGQKDWVFQPNQQYRRADDGGIVMTTNASGMFDFSNGARLQNPFTRDYHAAHWSSINIDWTTWAVNGIPQACDSWTTSEWIPKYAIYGMSDQVNENILTAKINFTKPCSDYYAAPLSDGTWSRLGLVCVEQPPPPKYIFVTSSNGEYHNANFGGIAGADAYCQSRIPSNIPNNRIYKAMLVDGINRIATTVGPNSTVGQKDWVFRPNQQYQRAEDGAIVMTTNSSGMFDFSNDARLQNPFTSNPRAAHWSSINIDWTTWAVNGIPKTCDSWTTSEWIPKYAIYGMSDQVNENILTAKINFTKPCSDYHAAPLGDGTWSNLGLVCVEE
>NZ_CP048830.1|WP_000468940.1|3985424_3986540_+|hypothetical-protein
MFHQADSKKNSILTLLKFQTFLFLFFFASYSTLKADDSTSLKKATLKDYTFQPYTQEGYFQAWNYSYRDDKIFIYATFLISNLGPGTKNCGISLVIHTLGEGTKFVTKEFSVKELSAEKGKFDLKIENNRMSLNSEGIEIQQDVENIKLFLSFKSDLKQGVSLSGGKHTVKDPGGFVQADMAFSFQSVWGYLIQDGKKKELLGTGGLEHLLTNYEVYKYSKRWELFRSINSKEFRFYTGGFLGNDSFPGGYFRTAALLNPEGKTILSGRIIKFEVLETAKEPFSGYDLPLKEKFYFEDDCSAEIIRKQSVGSIYVLSNISSVLRFFIRLFFAKPYQIYSLADLNVQCSNKNLSSDSLETFSGILSYYLINP
>NZ_CP048830.1|WP_011172394.1|3984973_3985393_+|hypothetical-protein
MKNTIDSNQEIWMKLISKKDDFIKIVSTLNEFYIPKVHFSKLDQGQKIRIQLVQKKVKNFEVFFKKRNDHEFIIFLKVGDQFTSWIHQDGIGEAKERFLMEGKTDHLVFKFPCIGDLYQKHCSIAQADEMKTLNGKDSA
>NZ_CP048830.1|WP_001983916.1|3984109_3984685_-|hypothetical-protein
MESDLLAIFWTEKIKLTQYIIQTTKNFSSKQLDFSVTPRESVRFFLQGMVAGDFFLRVSLPISVGISSILPIARQSEEEIEKDLVRLRDQLGSPALPIGIKEIITQSADELFFEDCNPELKPLFIRWKKILIRLEKTIQGLSTKDSLKYRYFSVIGIVSLPVAINYFEMQNLTWLRNGIMKIAENPNFPSQ
>NZ_CP048830.1|WP_001062719.1|3982844_3984041_-|NADP-dependent-isocitrate-dehydrogenase
MAKIKVKTPLVELDGDEMTRIIWKEIKDRFIHPYLDIELDYYDLGVEYRDKTDDKVTVDSAHAIQKYGVGVKCATITPNQDRVKEYNLKQEWKSPNGTIRSILDGTVFRKPIIVKNIPPAVRSWKKPITVGRHAYGDLYKDTELYIPEAGKVELVYTGKDGKEKQRALIHDFEGAGVIMGQHNLDKSILSFAQACFNYAISEKIDLWFATKDTISKKYHARFRAIFDELAKAKAADLKKAGIEYSYYLIDDAVAQLMKNEGGMLWALMNYDGDVMSDMVASGFGSLGLMTSVLVSPDGKFEYEAAHGTVTRHYRKYQQGETTSTNSVASIFAWTGALIKRGELDGTPDVVAFGHKLEKAVIDTIESGEMTKDLTLLCTDSNAKALDTFQFMEAIQKRL
>NZ_CP048830.1|WP_000801153.1|3995729_3996218_-|hypothetical-protein
MKPAEWFFVLSLLFAGLIYLFLLLVKRKEKDTSNSIVKYSLPKEDLNSSINRTSDSEDSRNSKMNVLEVFDYNGIKIMHENGIYTVNTGGEIEVYGSWQALPSRYQRMVKEMDHRATGEKKAGKYYMEILNGVYYVIFPDGKKHKYKRFEDIPEKIRKNLGY
>NZ_CP048830.1|WP_000250245.1|3996227_3996563_-|hypothetical-protein
MVQKIQFKTIIRIQLAIFILALFLSIGCYQKNTDADFYSFEDANTKLISAYESKDVICNTNRRLTAFVPGRSRKKDIDLCVSAVLAVSCESWASTSIDATPTTCKSIEFRY
>NZ_CP048830.1|WP_000798179.1|3997029_3997581_-|LEA-type-2-family-protein
MKNSKLRWIFLYLTLISLYSCSSLQENYKALQKCKFQVLSLETQKAEWLSFPPVPKIVFLAKIEIENPNETEVTLYKFDLSFIVPDNFEKEFLLAKIQSEEKIIIPALQKKTVDLQVETLFEKKMDRNLLQIVLGILQAGLAGKELEFKIQGNFEYDTILGSVRIPVNEKIPLKMGKKKGFEI
>NZ_CP048830.1|WP_001053085.1|3997585_3998608_-|zinc-binding-dehydrogenase
MNLPTTYKALELREYSENRNRANIVEKTIRPLKKGEVLIRMHSASINPSDLMFMRGLYGIKKKLPIVPGFEGSGNVVSSGGGFYASYLKGKNVACTASGRGDGVYAEYMITDAFNCLPIGKDLSLEQGACLYVNPITAIAMVERVQSLGIKALVQTAAASALGKMVVGIAARKGMKVINIVRKPEQEEVLKKIGAEYILNSESSNFERQLRILSKDLNATVCLDAVAGELTSRVLLAMPYGSRAIVYGALSEKEVPIHAGMMIFQDKKLEGFWLSTWVLQQTPYKIWKLSKELRSLAKKELKTDIASRFPLEKAVEAIDHYAVNMTKGKVLIQTSFAEGN
>NZ_CP048830.1|WP_000181227.1|3998604_3998931_-|(2Fe-2S)-ferredoxin-domain-containing-protein
MTNFYTKHVFVCENVRAEGERVSCGRSGSIQLLASLKKKMKDLSIEGKVRIQRAGCLDRCELGPVQVSYPEGRWFSLKTEEDVDIFLKYYIQSEQIQKIEHLIIKENQ
>NZ_CP048830.1|WP_002145703.1|3999351_3999819_+|DUF3347-domain-containing-protein
MKKFLILIISILTFFSSCKKPNPAVTEQEKDILQQILMENESIHKFLMKEEEKIPDTNQLIAHVVELVSLNGGLKSQAEKMQNSLKDKETQDVEKFFQAYSSFSENLAESLKLAGGTGVFNRFYCPMVNKTWVSQGTKIRNPYAPEMRDCGDLVH
>NZ_CP048830.1|WP_000264550.1|3999797_4000787_+|hypothetical-protein
MWGPSTLNVEVCLDKEIKTRCKIGVSLGEPCPANCRQNLLHNEWSSEIRESCIAGEKMNAFAEGKAGINVGASAFLQALPFVLEEFISKGRVYLEILIYFLSIIEPEKVKEVIDSFSNKLLYKIIIYEYNIYQQTEDERKSLKKNASFLDLRENAYWGSLSPERICSFIAYCLKEAKDPEFASQFLTVLPSEAVSDLRNLAGLNVEEEKELYLSLKDGIYELPIQIPGIYRHILSLFEDDPEIFLILSTMEELVLRKQQIIESSHAILEKYKSGKLNHQSLFGDLSVLELEISMEILGIFEEKEILGRSEKNLIKELLFKHKHLKNEIT
>NZ_CP048830.1|WP_000776815.1|4000795_4001578_-|PhzF-family-phenazine-biosynthesis-protein
MKLRMLQIDSFAEKVFQGNPAAVCPLQEWISDEWMQKIASENNLSETAFFVLEGESYRIRWFTPLREVDLCGHATLAAAYHLFREGEVIGDKLNFQSLSGELNVFKKENILYLDFPSRKPEKVETPKEILNSFSISPKEVFKSRDYMLLYENENQLKKLEYSVEGVRELNTLGIIATCVGNDSYDFLSRFFAPSVGLYEDPVTGSAHCTLIPFWSERLGKKIMKAYQTSARGGKLFCEDLGERVRIGGTCVPYLDGWIEI
>NZ_CP048830.1|WP_162839745.1|4002326_4002470_+|hypothetical-protein
MDRVVGTKFHRGLVVIPTRLILRYNTCGVGYWLLIGSLLEHSTNRVL
>NZ_CP048830.1|WP_000086941.1|4002630_4004103_-|amidophosphoribosyltransferase
MSRIPDKSRIRRQAQDDKPKEECAIFGIFNSSEASNFTYLGLYSMQHRGQESSGIVSSDGEHLYRYAGMGLVAHIFTETKLKELQGNAAIGHNRYSTTGASFLRNAQPLRVESHLGAVSLAHNGNLVNSWELRSQLEKEGSIFQTTIDSEVIVHLMARSGETDFLSALSSALKKVRGAYSLVILTKTQLIAVRDPNGFRPLVMGRREDGSIVFASETCAFDITDTKYERDVEPGEMIVVDKNGMNSYYPFPKASPSLCIFEYIYFARPDSSIFGESVYKVRKNLGRFLARELPVPADVVIPVPDSANIAALGYAEESGISYQSGLIRSHYIGRTFIEPDQKIRDFGAKIKYNVVRNVVEGKRVIVVDDSIMRGTTSRKIIKMIRNAGAKEIHLRVSAPPTISPCYYGIDIPTHNELIAATHTIEEIRKYLRVDSIAYLSVESMNRAVMDHKGGGFCNACFTAQYPVEFQSELGNQKSLFKEYQVEERVVY

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP048830_5	5.1\|1615038\|48\|NZ_CP048830\|CRISPRCasFinder	1615038-1615085	48	NZ_CP048830.1	1150689-1150736	1	0.979
NZ_CP048830_5	5.1\|1615038\|48\|NZ_CP048830\|CRISPRCasFinder	1615038-1615085	48	NZ_CP048830.1	3356383-3356430	1	0.979
NZ_CP048830_11	11.1\|3994773\|46\|NZ_CP048830\|CRISPRCasFinder	3994773-3994818	46	NZ_CP048830.1	1150689-1150734	1	0.978
NZ_CP048830_11	11.1\|3994773\|46\|NZ_CP048830\|CRISPRCasFinder	3994773-3994818	46	NZ_CP048830.1	3356385-3356430	1	0.978

1. spacer 5.1|1615038|48|NZ_CP048830|CRISPRCasFinder matches to position: 1150689-1150736, mismatch: 1, identity: 0.979

ccaacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
ccaacgcgacctgcagagcgacccttaggaagcgatgcattgagtttg	Protospacer
*****************************.******************

2. spacer 5.1|1615038|48|NZ_CP048830|CRISPRCasFinder matches to position: 3356383-3356430, mismatch: 1, identity: 0.979

ccaacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
ccaacgcaacctgcagagcgacccttagggagcgatgcattgagtttg	Protospacer
*******.****************************************

3. spacer 11.1|3994773|46|NZ_CP048830|CRISPRCasFinder matches to position: 1150689-1150734, mismatch: 1, identity: 0.978

aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
aacgcgacctgcagagcgacccttaggaagcgatgcattgagtttg	Protospacer
***************************.******************

4. spacer 11.1|3994773|46|NZ_CP048830|CRISPRCasFinder matches to position: 3356385-3356430, mismatch: 1, identity: 0.978

aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
aacgcaacctgcagagcgacccttagggagcgatgcattgagtttg	Protospacer
*****.****************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP048830_2	2.8\|1133867\|33\|NZ_CP048830\|PILER-CR	1133867-1133899	33	MK448894	Streptococcus phage Javan272, complete genome	6033-6065	9	0.727
NZ_CP048830_2	2.8\|1133867\|33\|NZ_CP048830\|PILER-CR	1133867-1133899	33	MK448888	Streptococcus phage Javan26, complete genome	6318-6350	9	0.727
NZ_CP048830_2	2.8\|1133867\|33\|NZ_CP048830\|PILER-CR	1133867-1133899	33	MK448725	Streptococcus phage Javan275, complete genome	6032-6064	9	0.727
NZ_CP048830_1	1.1\|442572\|47\|NZ_CP048830\|CRISPRCasFinder	442572-442618	47	NZ_CP020413	Leptospira interrogans serovar Copenhageni strain FDAARGOS_203 plasmid unnamed1, complete sequence	332409-332455	11	0.766
NZ_CP048830_1	1.1\|442572\|47\|NZ_CP048830\|CRISPRCasFinder	442572-442618	47	NZ_CP039285	Leptospira interrogans strain FMAS_AW1 plasmid pLiSL2, complete sequence	27503-27549	11	0.766
NZ_CP048830_1	1.1\|442572\|47\|NZ_CP048830\|CRISPRCasFinder	442572-442618	47	NC_025151	Leptospira interrogans serovar Lai str. 56601 plasmid Laicp, complete sequence	34985-35031	11	0.766
NZ_CP048830_1	1.1\|442572\|47\|NZ_CP048830\|CRISPRCasFinder	442572-442618	47	NZ_CP039260	Leptospira interrogans strain FMAS_KW1 plasmid pLiLS1, complete sequence	23249-23295	11	0.766
NZ_CP048830_1	1.1\|442572\|47\|NZ_CP048830\|CRISPRCasFinder	442572-442618	47	NZ_CP039260	Leptospira interrogans strain FMAS_KW1 plasmid pLiLS1, complete sequence	42721-42767	11	0.766
NZ_CP048830_1	1.1\|442572\|47\|NZ_CP048830\|CRISPRCasFinder	442572-442618	47	NZ_CP006726	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp2, complete sequence	36034-36080	11	0.766
NZ_CP048830_8	8.1\|2798150\|34\|NZ_CP048830\|CRISPRCasFinder	2798150-2798183	34	NZ_CP020413	Leptospira interrogans serovar Copenhageni strain FDAARGOS_203 plasmid unnamed1, complete sequence	218754-218787	11	0.676

1. spacer 2.8|1133867|33|NZ_CP048830|PILER-CR matches to MK448894 (Streptococcus phage Javan272, complete genome) position: , mismatch: 9, identity: 0.727

aatcaaggacgaattcttttgatcaaaggatcc	CRISPR spacer
agccaaggatgaattctttttatcaaagagaaa	Protospacer
*..******.********** *******..

2. spacer 2.8|1133867|33|NZ_CP048830|PILER-CR matches to MK448888 (Streptococcus phage Javan26, complete genome) position: , mismatch: 9, identity: 0.727

aatcaaggacgaattcttttgatcaaaggatcc	CRISPR spacer
agccaaggatgaattctttttatcaaagataaa	Protospacer
*..******.********** *******.

3. spacer 2.8|1133867|33|NZ_CP048830|PILER-CR matches to MK448725 (Streptococcus phage Javan275, complete genome) position: , mismatch: 9, identity: 0.727

aatcaaggacgaattcttttgatcaaaggatcc	CRISPR spacer
agccaaggatgaattctttttatcaaagagaaa	Protospacer
*..******.********** *******..

4. spacer 1.1|442572|47|NZ_CP048830|CRISPRCasFinder matches to NZ_CP020413 (Leptospira interrogans serovar Copenhageni strain FDAARGOS_203 plasmid unnamed1, complete sequence) position: , mismatch: 11, identity: 0.766

gaaactcagcataacgctctttatgaatcgcgttggaaactcagcat	CRISPR spacer
gaaactcagcacaacgctctctatgaatcgcgttgtggggtgggaac	Protospacer
***********.********.************** ... * .* *.

5. spacer 1.1|442572|47|NZ_CP048830|CRISPRCasFinder matches to NZ_CP039285 (Leptospira interrogans strain FMAS_AW1 plasmid pLiSL2, complete sequence) position: , mismatch: 11, identity: 0.766

gaaactcagcataacgctctttatgaatcgcgttggaaactcagcat	CRISPR spacer
aaaactcagcacaacactctttatgaatcgcgttgtggagtgggaac	Protospacer
.**********.***.******************* ..* * .* *.

6. spacer 1.1|442572|47|NZ_CP048830|CRISPRCasFinder matches to NC_025151 (Leptospira interrogans serovar Lai str. 56601 plasmid Laicp, complete sequence) position: , mismatch: 11, identity: 0.766

gaaactcagcataacgctctttatgaatcgcgttggaaactcagcat	CRISPR spacer
aaaactcagcacaacactctttatgaatcgcgttgtggagtgggaac	Protospacer
.**********.***.******************* ..* * .* *.

7. spacer 1.1|442572|47|NZ_CP048830|CRISPRCasFinder matches to NZ_CP039260 (Leptospira interrogans strain FMAS_KW1 plasmid pLiLS1, complete sequence) position: , mismatch: 11, identity: 0.766

gaaactcagcataacgctctttatgaatcgcgttggaaactcagcat	CRISPR spacer
aaaactcagcacaacactctttatgaatcgcgttgtggagtgggaac	Protospacer
.**********.***.******************* ..* * .* *.

8. spacer 1.1|442572|47|NZ_CP048830|CRISPRCasFinder matches to NZ_CP039260 (Leptospira interrogans strain FMAS_KW1 plasmid pLiLS1, complete sequence) position: , mismatch: 11, identity: 0.766

gaaactcagcataacgctctttatgaatcgcgttggaaactcagcat	CRISPR spacer
aaaactcagcacaacactctttatgaatcgcgttgtggagtgggaac	Protospacer
.**********.***.******************* ..* * .* *.

9. spacer 1.1|442572|47|NZ_CP048830|CRISPRCasFinder matches to NZ_CP006726 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp2, complete sequence) position: , mismatch: 11, identity: 0.766

gaaactcagcataacgctctttatgaatcgcgttggaaactcagcat	CRISPR spacer
aaaactcagcacaacactctttatgaatcgcgttgtggagtgggaac	Protospacer
.**********.***.******************* ..* * .* *.

10. spacer 8.1|2798150|34|NZ_CP048830|CRISPRCasFinder matches to NZ_CP020413 (Leptospira interrogans serovar Copenhageni strain FDAARGOS_203 plasmid unnamed1, complete sequence) position: , mismatch: 11, identity: 0.676

gattcatcaaaactttcgtgggagttcccacaac	CRISPR spacer
taaaagaagaaattttcgtgggagttcccataaa	Protospacer
 *   .  .***.*****************.**

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

993711 : 1007078

Leptospira_phage(100.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000835580.1\|993711_994335_-	tetratricopeptide repeat protein	S5VKQ0	Leptospira_phage	5.3e-50	56.4
WP_001032052.1\|994343_996083_-	hypothetical protein	S5VKK9	Leptospira_phage	4.8e-226	79.1
WP_000162787.1\|996079_996964_-	hypothetical protein	S5VSU6	Leptospira_phage	5.2e-136	82.0
WP_001984041.1\|997266_1004274_+	membrane protein	S5W9E6	Leptospira_phage	0.0e+00	73.1
WP_000692278.1\|1005023_1005875_+	hypothetical protein	S5W9A4	Leptospira_phage	6.0e-105	68.4
WP_001011312.1\|1005941_1007078_-	hypothetical protein	S5W9G5	Leptospira_phage	2.7e-12	62.9

DBSCAN-SWA_2

2565923 : 2575371

Enterobacteria_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000842260.1\|2565923_2566808_-	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	4.8e-97	60.3
WP_000723090.1\|2566808_2567858_-	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	4.5e-94	51.2
WP_000642158.1\|2567854_2568775_-	dTDP-4-dehydrorhamnose reductase	NA	NA	NA	NA
WP_001159758.1\|2568778_2569339_-	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	3.5e-45	52.9
WP_000854002.1\|2569535_2571284_-	glycosyltransferase	A0A0F7L2F7	uncultured_marine_virus	7.7e-06	33.3
WP_000282880.1\|2572008_2572830_-	glycosyltransferase	A0A0F7L2F7	uncultured_marine_virus	2.4e-10	30.0
WP_000560752.1\|2573339_2574137_-	glycosyltransferase	A0A0F7L2F7	uncultured_marine_virus	2.1e-06	35.6
WP_000575178.1\|2574279_2575371_-	DegT/DnrJ/EryC1/StrS family aminotransferase	A0A2P1ELT3	Moumouvirus	3.1e-37	31.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP048830

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection