CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP048836	Azoarcus sp. M9-3-2 chromosome, complete genome	5 crisprs	csa3,DinG,DEDDh,Cas9_archaeal,WYL	3	1	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP048836_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048836_1

812444-812508

Orphan

Consensus_repeat	Method
TCCGGCGGCTCGGGTGGCTCCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP048836_1

>merge|NZ_CP048836|1|812444-812508|CRISPRCasFinder
TCCGGCGGCTCGGGTGGCTCCACGGGCCATGCCACCGGCGGTTCCGGCGGCGACGGCGGCTCCGG

>NZ_CP048836|1|1|812444-812508|CRISPRCasFinder
TCCGGCGGCTCGGGTGGCTCCAC	GGGCCATGCCACCGGCGGT
TCCGGCGGCGACGGCGGCTCCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048836.1\|WP_173768569.1\|813993_814248_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048836.1\|WP_173763983.1\|806069_806912_-\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NZ_CP048836.1\|WP_173763982.1\|804585_806004_-\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|236901
NZ_CP048836.1\|WP_173763981.1\|803962_804589_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|226932
NZ_CP048836.1\|WP_173763985.1\|808361_808787_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048836.1\|WP_173763977.1\|799600_800203_+\|chemotaxis-protein-CheD	unknown	unknown	gnl\|CDD\|319352
NZ_CP048836.1\|WP_173763993.1\|821348_821840_-\|ATPase	unknown	unknown	unknown
NZ_CP048836.1\|WP_173763986.1\|809328_811533_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237537
NZ_CP048836.1\|WP_173763978.1\|800300_802331_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|236901
NZ_CP048836.1\|WP_173763990.1\|817354_818689_-\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NZ_CP048836.1\|WP_173763995.1\|822876_823554_-\|Bax-inhibitor-1/YccA-family-protein	unknown	unknown	gnl\|CDD\|198415
NZ_CP048836.1\|WP_173763980.1\|803256_803856_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|225783
NZ_CP048836.1\|WP_173763992.1\|820763_821327_+\|DUF882-domain-containing-protein	unknown	unknown	gnl\|CDD\|283577
NZ_CP048836.1\|WP_173763991.1\|819046_820753_-\|L,D-transpeptidase-family-protein	unknown	unknown	gnl\|CDD\|225536
NZ_CP048836.1\|WP_173763988.1\|814261_814942_+\|C39-family-peptidase	unknown	unknown	gnl\|CDD\|239103
NZ_CP048836.1\|WP_173763989.1\|815009_815879_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237537
NZ_CP048836.1\|WP_173763994.1\|822040_822808_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|131480
NZ_CP048836.1\|WP_173768572.1\|816004_817255_-\|acetate-kinase	unknown	unknown	gnl\|CDD\|377222
NZ_CP048836.1\|WP_173763979.1\|802327_802693_+\|response-regulator	unknown	unknown	gnl\|CDD\|381092
NZ_CP048836.1\|WP_173763984.1\|806929_808333_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635

Protein	Function_ID	Function_description	E-value
NZ_CP048836.1\|WP_173763983.1\|806069_806912_-\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	2.76877e-29
NZ_CP048836.1\|WP_173763982.1\|804585_806004_-\|PAS-domain-S-box-protein	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	9.96628e-31
NZ_CP048836.1\|WP_173763981.1\|803962_804589_-\|response-regulator-transcription-factor	gnl\|CDD\|226932	COG4566, TtrR, Response regulator [Signal transduction mechanisms].	3.22703e-63
NZ_CP048836.1\|WP_173763977.1\|799600_800203_+\|chemotaxis-protein-CheD	gnl\|CDD\|319352	cd16352, CheD, chemotaxis protein CheD stimulates methylation of methyl-accepting chemotaxis proteins. This family contains bacterial chemotaxis protein CheD that stimulates methylation of methyl-accepting chemotaxis proteins (MCPs). The CheD chemotaxis gene is not found in the Escherichia coli genome, but is present in many other organisms, including B. subtilis, where CheD appears to have two separate roles; it binds to chemoreceptors to activate them as part of the CheC/CheD/CheYp adaptation system, and it deamidates selected residues to activate chemoreceptors, enabling them to mediate amino acid chemotaxis. CheD has been shown to catalyze amide hydrolysis of specific glutaminyl side chains of the B. subtilis chemoreceptors McpA, McpB and McpC; deamination by CheD is required for the chemoreceptors to effectively transduce signals to the CheA kinase. CheD's ability to bind the receptors is controlled by CheC via a competitive binding mechanism; substituting Gln into the receptor motif of the signal-terminating phosphatase, CheC, turns the inhibitor into a receptor-modifying deamidase CheD substrate. Also, CheYp increases the affinity of CheD for CheC, controlling CheD binding to the receptors through its interactions with CheC. Thus, high levels of CheYp means CheC is a better binding target for CheD than the receptors, resulting in decreased CheA activity. The CheD structure reveals a distant homology with a class of bacterial toxins represented by the cytotoxic necrotizing factor 1 (CNF1) as well as a class of proteins of unknown function represented by B. subtilis YfiH. An invariant Cys-His pair forming a catalytic dyad is observed, and is required by the toxins for deamidation activity.	4.40946e-52
NZ_CP048836.1\|WP_173763986.1\|809328_811533_+\|hypothetical-protein	gnl\|CDD\|237537	PRK13875, PRK13875, conjugal transfer protein TrbL; Provisional.	3.95805e-06
NZ_CP048836.1\|WP_173763978.1\|800300_802331_+\|PAS-domain-S-box-protein	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	4.78636e-40
NZ_CP048836.1\|WP_173763990.1\|817354_818689_-\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	6.53158e-134
NZ_CP048836.1\|WP_173763994.1\|822040_822808_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	3.81665e-19
NZ_CP048836.1\|WP_173763980.1\|803256_803856_-\|alpha/beta-hydrolase	gnl\|CDD\|225783	COG3243, PhaC, Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism].	2.53046e-41
NZ_CP048836.1\|WP_173763992.1\|820763_821327_+\|DUF882-domain-containing-protein	gnl\|CDD\|283577	pfam05951, Peptidase_M15_2, Bacterial protein of unknown function (DUF882). This family consists of a series of hypothetical bacterial proteins of unknown function.	9.67082e-55
NZ_CP048836.1\|WP_173763991.1\|819046_820753_-\|L,D-transpeptidase-family-protein	gnl\|CDD\|225536	COG2989, COG2989, Uncharacterized protein conserved in bacteria [Function unknown].	1.51823e-119
NZ_CP048836.1\|WP_173763995.1\|822876_823554_-\|Bax-inhibitor-1/YccA-family-protein	gnl\|CDD\|198415	cd10433, YccA_like, YccA-like proteins. A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.	1.48454e-94
NZ_CP048836.1\|WP_173763989.1\|815009_815879_+\|hypothetical-protein	gnl\|CDD\|237537	PRK13875, PRK13875, conjugal transfer protein TrbL; Provisional.	0.00366895
NZ_CP048836.1\|WP_173763984.1\|806929_808333_-\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	4.78319e-54
NZ_CP048836.1\|WP_173768572.1\|816004_817255_-\|acetate-kinase	gnl\|CDD\|377222	pfam04102, SlyX, SlyX. The SlyX protein has no known function. It is short less than 80 amino acids and is found close to the slyD gene. The SlyX protein has a conserved PPH(Y/W) motif at its C-terminus. The protein may be a coiled-coil structure.	0.000262261
NZ_CP048836.1\|WP_173763979.1\|802327_802693_+\|response-regulator	gnl\|CDD\|381092	cd17537, REC_FixJ, phosphoacceptor receiver (REC) domain of FixJ family response regulators. FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.83249e-32
NZ_CP048836.1\|WP_173763988.1\|814261_814942_+\|C39-family-peptidase	gnl\|CDD\|239103	cd02423, Peptidase_C39G, A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage is mediated by the transporter as part of the secretion process. Bacteriocins are antibiotic proteins secreted by some species of bacteria that inhibit the growth of other bacterial species. The bacteriocin is synthesized as a precursor with an N-terminal leader peptide, and processing involves removal of the leader peptide by cleavage at a Gly-Gly bond, followed by translocation of the mature bacteriocin across the cytoplasmic membrane. Most endopeptidases of family C39 are N-terminal domains in larger proteins (ABC transporters) that serve both functions. The proposed protease active site is conserved in this sub-family of proteins with a single peptidase domain, which are lacking the nucleotide-binding transporter signature.	1.80131e-53

>NZ_CP048836.1|WP_173763986.1|809328_811533_+|hypothetical-protein
MRRTLLSTAIALAFGVSGSVFANPTIYGDSAGTGSGNDTVNQSATATSTQGDGPNANENSSVKVGSANTAISDTGNDNSAGSNRDNDGKAEAWGHGTAAANNGASASASFSSAFNSSKAIAISKLNGSVTNNSVSGLGNMVTNSGNANGDRGGWGGRGGDGYGGDATGGNASGGTGGAGGNAGNGGAGGSGGSGGYAVNGSATADGASNGGASNGSATAGNGGDGGSARGAYGANGGDSGSAKAIGGDGGSGYGGDGTGGAGVGGAGGMAYGGSGGKAIGGDGGNGGGGSGGMSGSASGGSGGSTQNATGGDGGSGGSGGYGGSTGYAIGGDGGSGGAGGNGALGSGDGGKASAYTGASGGDAGTLSKAAGGSAYGDGGKGGYSGAYAGTSTGGASGDGGVVGNQGNANGGLASGEGAGGTGGNASGTSTGNTTGAAGMSGDPTASAQGGSGGAASATGGTAAAGTANSGGGATSDTSAMASGGAGTGTGGSGAAGATGAAGAAATNSAGSGATGATGAAGAMATNSAGDGATGASGTGGAGAAAAGGTGAMASSAGADGNGGAGAVGNGGVGNAAAGNGGLGGAAVNTTGDGGTGGMAANTGGAGGAGGSASNGSATNGDATSMASNGSATAGDGAVGAQGAAGGDGGAGGTGQGGTGGDGLAADGNGATGGAGGAGGAGGMISLDAGAFNMSNTISGSFTNGAGIMVSSQNTGMASLVQQSVNVQANLAVGH
>NZ_CP048836.1|WP_173763985.1|808361_808787_-|hypothetical-protein
MQKTETTTPHPIIEHMERTQALACAEWDAAQRILDIQSAALRRLMALPNGKGAHRAPAAPGGMADLAAPWAGLYQQAIDTAMEASAISMDTLAQIQNEMVNCSHEILPLFQRGVADGVERLSRAMASLPAVTAPARHDKSA
>NZ_CP048836.1|WP_173763984.1|806929_808333_-|diguanylate-cyclase
MSPKHIDETSTPETPSRVAPAAPAPMLAGAAFPPLTDQAVLVATARGTIEYGTDAARRLLQAADRRLEGESLATLLPELPLRAATPGYNCAYLVFNHPPGRWHPLTVATPDGGSVTLEAAFLFIPLGDTTRILVGLRTPTPGSADDAHFQRFLARMETSDDAVVVTDAEGVVEYVNPAYERLSGWRREALVGRPRRPAALATTTAAPGAGSQVRDTLRTERTRSGRALYLDEQVRPFTDRSGHVTHYVCTARDVSRRIASERALQRRANFDSLTGIANRHLLIHRLNQELSRAAREGGAFAVVCADMDGLKAINDAFGHAAGDAAIRAVAERLTHCVRDMDTVGRFGGDEFLLVVPGLHRPADVDALLGKLVASVRDARVGDAAPVRLALSAGAALYPRDGRDAGALVQAADAAMYTAKRLGGDRHWSCVGLAPSPAAAERAVTRCLQPVPVLPRRPATAVQHPSVG
>NZ_CP048836.1|WP_173763983.1|806069_806912_-|Crp/Fnr-family-transcriptional-regulator
MLRHQFPPGAPPRAVPPDDGQPLARQLGQGLIDAASLARFLGLSLHPAPHPEWARFQCRRFRPGEVPIRAGDPCRYLYVVIRGSVCTRVVDAEGAERIIGFERAADSLGLDGLASGRHTTEAIVLEPTDMVVIPLAGLARPGHEGAALGSFIYRLLGRQILRDQAAMAMMAASRATTRLGAFLLDWYQRSETPARTVALPMSRMDIASFLGLSKETVSRACSALDRAGIVAMRRRRFTILDPAALHRTAAGAIACEGTPVRGRWRELDLAQERGCRPSVR
>NZ_CP048836.1|WP_173763982.1|804585_806004_-|PAS-domain-S-box-protein
MTRGLSDDLLQVFEASVDAMLIADAQGRIRRINPALRHLFGLPPEAAGLEVNDLVPESLRAAHARQMSAYRQAPKSRPMGACGPLRARRADGSEFPAEVSLSPLPDGRVLATVHDISARVAAQASAQQWSERYACLLGAIPDLVVEVDGAGRLGWGNAAAQRFFGDDLAGQALAGFHDARPPAADVDPVDGEHWFRRTDGELRLLSWHCSALDDAGTRICSARDVTERHRSVEIERNLRAQMRQMHGLQVAGQTVRMIAHDLNQPLNAVSAYATAALRLIDEQGDPARLRAALHGCCDEVDRAGEVMATLMNFLARDALQPEPINLDRAVRNVVRLCEADGDRNTRFEIDVAPDLWQAMGNQRQFESVLHSLITNSVEALRHSGVSAPSIRIEARNDPTHPAVQVTLSDNGPGLDEHTATQAFAPFFTTKLRAVGLGLTISRALIEAGGGELWYDGDAAPGATFRFTVPARP
>NZ_CP048836.1|WP_173763981.1|803962_804589_-|response-regulator-transcription-factor
MNEICHNEPTVFIVDDDAGVRRSVRMLMESAGHAATTFDSAEAFLHAYRPEWRGCLILDVNMGAMSGTTLHQTLNARRIALPIIYLTAHGDVPSAVQAMRRGAVDFLIKPVRGPVLLAQVEAALAAQHRADPAPAAPALDGLTPREIEIAERALAGLGNKEIARQLGISHRTVEYHRTQILHKTGASSFLQLASRLAAPDDEGAASGA
>NZ_CP048836.1|WP_173763980.1|803256_803856_-|alpha/beta-hydrolase
MDERLLGRRAPMTDLMAWNADATRMPYRMHGEYLRRCFLDNDLFEGRYTVDGRAIVLGDIRMPLFVVATERDHVSPWRSVYQIKLVADTEVSVLLTSGGHNAGIVSEPSHAGRRYRYTPAHKDEHYLDPDSGFAATPATEGSWWPCWAEWLEARSSGQNAAPGSRSRTPAAPAFIPPSPREHATWTRHSWADGSRACRP
>NZ_CP048836.1|WP_173763979.1|802327_802693_+|response-regulator
MSEPTVHLVDDDPSVRTAFGWLFESVGLPVRSYPDGEAFLAAFDPAMRGCVVVDGHMPGLGGIGLLQALRRRGNRMPVLYLSGCHDADSTAAARAAGVAAICTKPIAGAALLDQVRALLDT
>NZ_CP048836.1|WP_173763978.1|800300_802331_+|PAS-domain-S-box-protein
MGERTSGEEPAPAPVAAEAITLASAPVERRHRRAVWVAVLLMGALFAVAVPFAKRPLGALPAFLPLFQSALIACEAITGVLLFGQFRTQRSVALLILAGGYFFSAFMAIAHLLSFPGLLAPAGVIGGGAQTTAWLYFGWHAGFPLFVIAYAVARRQQAVARSDTEPAAGLAPAMFLGVVTLVAGLTVLATVFEASLPVIMAGHLDAPAKAVVAHATWLTGCVALVVLLARRPPVLLDMWLIVVMGAWLFDVGLSASLNHGRFDLGWYAGRMFGLAAAVLVLVKLLLENSALHRQVLALRDQERRRAAERLRSSERRFEAIFEQAPVGIAHVSLDGHWLQVNTRLCEIMGYPAEELKRCTFPDILSPGGRAAAQALRRQMLAGQIERHTEERRYVRRDGRVVWVRVRTALVREADGAPAYFVSVVSDLTEQRVAEDKVHVLNREMARMAQLEVANQTVTALAHELNQPLSAVSAAATAARHMLHAGHWSEARLAVMLDGAEQAALRAGQVLQDMVSFINQGKVSSDPIDINGLLSALMDRYRHNHAAADYTLRLELQPDMAPVLANRLRLEKVLTNLIDNGIEAMLDRGARGEACVTVSTRAEGATAHVRVADAGPGLDPASAERIFDPFFTTKTNGLGMGLAVSRAIVESHGGHLWAESPADGGAVFHLTLPLAAP
>NZ_CP048836.1|WP_173763977.1|799600_800203_+|chemotaxis-protein-CheD
MRPHPAAPAPPAVDVGALLARARNLNPGAWAVERERPLATLLGSCVAVCLHDPRRRLAGMNHFLLPSRHGTRHDQTDIVLAGDAAMEVLANAMFARGAVKADLVAKVFGGGTITSTIDLAIGERNARFALEWLAREGIRTVAQDVMGRFSRRLVFDPASGDAWCRRQAVDGSAVRRLAQAEAALAQRLSAAPGGGIELFG
>NZ_CP048836.1|WP_173768569.1|813993_814248_+|hypothetical-protein
MLADLGGAALSPDALAAQRGGTETLSDMKLGGVVANNQASDLVTGHNIVSDGSLTGNAGFATVVQNTGNNVLIQNATIINLQLQ
>NZ_CP048836.1|WP_173763988.1|814261_814942_+|C39-family-peptidase
MNRLTRITAALAVGWSLSAGAAQLSFPTDVVGPYTLRVTSLKEARHLGTIQQQYDFSCGSAALATLLTHHYGYAVTEQVVFRVMYLRGDQAKIRREGFSLLDMKNFLAANGFASDGFEAPLEALTKAKVPAIALVSEMGYHHFVVIKGLQDGRVLIGDPARGTRAVSRSAFEAMWHNKILFVIKNHLEAARFNRAADWRVAPRAPLEAGLRGLPNAIPAMRAVSDF
>NZ_CP048836.1|WP_173763989.1|815009_815879_+|hypothetical-protein
MLHSNPLAAAVLGALGLLMASGLGAAESPLAGPALSAARLDAIRGGFELPDLKLKLSFGLERAVFVNGELVARTTLNLSQLRDTVAARVDAAIPDGAALQAQVQAQVAAQLASAGIATVVLPVRSAAEVVTPAGASAVEMRATPGAATGAATAQAGTASAQTAGAAAGQALADTGVSAAAAGSPGTTAVAGGTTASVTEAASGQRATVVSTVAPLPVAVIQNGAGNQVGPRVAAAVDSAAIATVIQNSLDNQQIQALTVVNASANSLQVLRAMNFGAAIRQGVIQSLRR
>NZ_CP048836.1|WP_173768572.1|816004_817255_-|acetate-kinase
MVSVGLCTPARADETDSARLIEQLRRQVAEQREQIDAMRKTMAEQQGRLAEIRQALGLDQLGTLRGAGQPGAGAPPRVAQAAPAAPVGQRPSEAKTEAENPPVAQIFSQPGILTQPGKYVLEPSLQYSYSSSNRVALVGYTVIPALTIGLIDVREVKSHIWTAALTGRMGLTNRLELEGKIPWVYRNDDSISRPIATPASNDEVFNTSGRGLGDIEFTARYQFNDGGADTPYYIGSLRFKSRTGSDQFDTTTVAIPGFQGLGLPKELPTGSGFYSLQPGLTFLFPSDPVVFFGGLNYQYSFKRNDINVKQDDGQGNITVTHFDSVQPGGVFGFNFGMGLALNDKSSFSIGYEHATVGRTRLNGRSDPLSVRVDLGTLLLGYAYRLSPKQSINVALGIGVTNDTPDVQLTLRAPMNF
>NZ_CP048836.1|WP_173763990.1|817354_818689_-|sigma-54-dependent-Fis-family-transcriptional-regulator
MSLRDALIYDARGQVLRELAAQGFDDWQFHRAATPAEAVALHERGGCRVGIAVFDQALDPIPDPLARLVAEAEVEWVALASPEALMHPVLGPFIVHTFHDYHTLPLDPPRLRVTLGHAHGKAERRHQMRDASLRSSGRFGMTGRSPAMQRLYRQLDKVVGADAPVLLSGESGTGKELVARAIHDYSARADGPFVAMNCAAIPASLIQSELFGHEKGAFTGALQRKIGNIEASDRGVLFLDEIGDLSLELQANLLRFLQEMNVVRLGATRHVDVDTRVVAATHVDLHSAVAHEQFRADLFYRLDVVHLHLPPLRERVEDIALLAHTIFDKYATQHPTPVRGFSDEAVQAMEAHLWPGNVRELINRVRHAMIMSEHRLILPEDLGLAAPVDTPPVMTLQRARTHLDRDMIERSLRQNHCNVSQSARQLGISRVTLYRLMNRLNINP
>NZ_CP048836.1|WP_173763991.1|819046_820753_-|L,D-transpeptidase-family-protein
MTERNTAAHILLEARRARAAVRRPAGGARLLLWLLVTGLALVAATVRADPLNEALRERVELLRRGRAIAVAGGLVSADGAVTRLYEARGFRPAWTSPERRQALLRAVEASADDGLEPADYQNAALRAAAAAPADDARTIADRDLLFTAALLRLAAHVHTGKVDPARLDPDWGFARRTDGDDLAALEALVDAPDLAQALRQWAPRLDAYVGLRTALARYRRIAADGGWPSLPDGPTLRPDTVDARVAILRDRLAITDDAPTVAGPDAERFDAALREALVRFQRRHGLETDGLAGRRTRAALNVDVRRRIDQIRVNLERLRWLAPELAGDQLQVDVAAFAASLRLDGHVVWSSRAIVGRPDRPTPSFGATLRYLVLNPEWVVPPTILRQDMLPRIIAQPAYLAEHALHLEDFAGQPVDPQSIEWARYRHDGFPFQLVQPPGPDNPVGRIKFVFPNPYSVYLHDTPAKALFDKPERAFSSGCIRLQRPLELALALLDDPIRWPTEALEAAITTGQTRTLTVPRQVPVRVLYLTATANADGQVDFRRDIYARDPAVLAALQRPIATPTHGHR
>NZ_CP048836.1|WP_173763992.1|820763_821327_+|DUF882-domain-containing-protein
MPKLPHARPCPTRRRLIQTLGGLSLGLGLGNAWGRTEPCRLSFHHLHTGERLSTVYRVDGRYQREALTRIAWLLRDFRTGKTHPMDPQLLDILHALSLRCEGETFEVISGYRAPATNAMLARTTSGVARHSLHMEGRAIDVRLTGRATAQLRDAALALRRGGVGFYPDSDFVHLDTGRVRAWGPRGA
>NZ_CP048836.1|WP_173763993.1|821348_821840_-|ATPase
MKRHDLVWRPIRRDELRTEFIHDPYRARLKYSDGTRCPDCGAHFDRGRWHWRDEPATQEALCPACHRIRDHLPAGYVTISGEFAHAHRDEIVRLIRHHETREKAEHPLNRIIALEARNGELAITTTDVHLARNLGEALHDAYQGDLDYHYNDAEYLLRVNWSR
>NZ_CP048836.1|WP_173763994.1|822040_822808_+|alpha/beta-fold-hydrolase
MNDMIDIRGAMLEVAHWPSDAPRGDAPPILMLHEGLGSLGLWRDFPQRVAEASGCDVYAYSRIGYGRSDPFRAPRTPAYLHEQAQVDLPAVVAALGLERPVLFGHSDGGSIALIAAGSTDLALAGVVVMAPHVRVEAVTLRGIEAAARQWACSDWPQRLARHHRDAPAVFAAWRDTWLAPDFRDWNIEHLLPAIACPVLAIQGEDDEYGTMAQIDRIAAAAPEARLLKLPGCGHVPHRDCPDQVLDAVAGFVATL
>NZ_CP048836.1|WP_173763995.1|822876_823554_-|Bax-inhibitor-1/YccA-family-protein
MNRTSPFPGQVGQVRQQSVLATNKVIRNTYVLLSMTLLFSAVTAGASMVMNLPYPGPIITLVGYFGLLFLTTRLRNSGWGILSVFALTGFMGYTLGPILNFYAHMPNGGQTVMTAMGLTGAIFLGLSGYALTTRKNFSFMGGFLTVGILVAFLAGLGALFFSIPALSLTVSAAFVLLMSGLILYETSNIIHGGETNYIMATVSLYVSLFNLFTSLLHLLGALNDD

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Crispr_ID: NZ_CP048836_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048836_2

1230314-1230424

Orphan

Consensus_repeat	Method
CGGGGGGCAGCGAGCACAGCGAGCGTGGGGGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP048836_2

>merge|NZ_CP048836|2|1230314-1230424|CRISPRCasFinder
CGGGGGGCAGCGAGCACAGCGAGCGTGGGGGCCGAGCGCACCGCCCGCCGGGCCGCCCCAAGGGCGGTGCAGCCCCCTCGGGGGGCAGCGAGCGCAGCGAGCGTGGGGGCC

>NZ_CP048836|2|2|1230314-1230424|CRISPRCasFinder
CGGGGGGCAGCGAGCACAGCGAGCGTGGGGGCC	GAGCGCACCGCCCGCCGGGCCGCCCCAAGGGCGGTGCAGCCCCCT
CGGGGGGCAGCGAGCGCAGCGAGCGTGGGGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048836.1\|WP_173764334.1\|1232614_1234060_-\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|235619
NZ_CP048836.1\|WP_173764325.1\|1221443_1223513_-\|M3-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341051
NZ_CP048836.1\|WP_173764324.1\|1219664_1221476_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NZ_CP048836.1\|WP_173764326.1\|1223681_1224455_-\|DUF2189-domain-containing-protein	unknown	unknown	gnl\|CDD\|227760
NZ_CP048836.1\|WP_173764341.1\|1241979_1242789_-\|inositol-monophosphatase-family-protein	unknown	unknown	gnl\|CDD\|238815
NZ_CP048836.1\|WP_173764329.1\|1226622_1228101_-\|MBOAT-family-protein	unknown	unknown	gnl\|CDD\|224610
NZ_CP048836.1\|WP_173764323.1\|1218743_1219505_-\|exodeoxyribonuclease-III	unknown	unknown	gnl\|CDD\|197320
NZ_CP048836.1\|WP_173764335.1\|1234162_1235314_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_CP048836.1\|WP_173764327.1\|1224583_1225519_-\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|237571
NZ_CP048836.1\|WP_173764328.1\|1225576_1226614_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238863
NZ_CP048836.1\|WP_173764331.1\|1229564_1229975_-\|gamma-glutamylcyclotransferase	unknown	unknown	gnl\|CDD\|119400
NZ_CP048836.1\|WP_173764339.1\|1238864_1240895_-\|transketolase	unknown	unknown	gnl\|CDD\|183723
NZ_CP048836.1\|WP_173764336.1\|1235464_1236649_-\|phosphoglycerate-kinase	unknown	unknown	gnl\|CDD\|234613
NZ_CP048836.1\|WP_173764333.1\|1231604_1232354_-\|5,6-dimethylbenzimidazole-synthase	unknown	unknown	gnl\|CDD\|380321
NZ_CP048836.1\|WP_173764338.1\|1237785_1238814_-\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|223135
NZ_CP048836.1\|WP_173764322.1\|1218033_1218747_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|315383
NZ_CP048836.1\|WP_173764332.1\|1230437_1231502_-\|fructose-bisphosphate-aldolase-class-II	unknown	unknown	gnl\|CDD\|181691
NZ_CP048836.1\|WP_173764337.1\|1236696_1237725_-\|erythrose-4-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|130595
NZ_CP048836.1\|WP_173764330.1\|1228198_1229488_-\|DUF3422-domain-containing-protein	unknown	unknown	gnl\|CDD\|378758
NZ_CP048836.1\|WP_173764340.1\|1241048_1241924_-\|phosphoribulokinase	unknown	unknown	gnl\|CDD\|237970

Protein	Function_ID	Function_description	E-value
NZ_CP048836.1\|WP_173764334.1\|1232614_1234060_-\|pyruvate-kinase	gnl\|CDD\|235619	PRK05826, PRK05826, pyruvate kinase; Provisional.	0
NZ_CP048836.1\|WP_173764325.1\|1221443_1223513_-\|M3-family-metallopeptidase	gnl\|CDD\|341051	cd06456, M3A_DCP, Peptidase family M3, dipeptidyl carboxypeptidase (DCP). Peptidase family M3 dipeptidyl carboxypeptidase (DCP; Dcp II; peptidyl dipeptidase; EC 3.4.15.5). This metal-binding M3A family also includes oligopeptidase A (OpdA; EC 3.4.24.70). DCP cleaves dipeptides off the C-termini of various peptides and proteins, the smallest substrate being N-blocked tripeptides and unblocked tetrapeptides. DCP from Escherichia coli is inhibited by the anti-hypertensive drug captopril, an inhibitor of the mammalian angiotensin converting enzyme (ACE, also called peptidyl dipeptidase A). OpdA may play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. It can also cleave N-acetyl-L-Ala. This family also includes Arabidopsis thaliana organellar oligopeptidase OOP (At5g65620), which plays a role in targeting peptide degradation in mitochondria and chloroplasts; it degrades peptide substrates that are between 8 to 23 amino acid residues, and shows a weak preference for hydrophobic residues (F/L) at the P1 position.	0
NZ_CP048836.1\|WP_173764324.1\|1219664_1221476_+\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	2.49756e-59
NZ_CP048836.1\|WP_173764326.1\|1223681_1224455_-\|DUF2189-domain-containing-protein	gnl\|CDD\|227760	COG5473, COG5473, Predicted integral membrane protein [Function unknown].	1.63977e-39
NZ_CP048836.1\|WP_173764341.1\|1241979_1242789_-\|inositol-monophosphatase-family-protein	gnl\|CDD\|238815	cd01637, IMPase_like, Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-bisphosphate, inositol poly- and monophosphates, PAP and PAPS, sedoheptulose-1,7-bisphosphate and probably others.	2.67539e-67
NZ_CP048836.1\|WP_173764329.1\|1226622_1228101_-\|MBOAT-family-protein	gnl\|CDD\|224610	COG1696, DltB, Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane].	3.73721e-84
NZ_CP048836.1\|WP_173764323.1\|1218743_1219505_-\|exodeoxyribonuclease-III	gnl\|CDD\|197320	cd09086, ExoIII-like_AP-endo, Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases. This subfamily includes Escherichia coli ExoIII, Neisseria meningitides NExo,and related proteins. These are ExoIII family AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiencies. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity. For example, Neisseria meningitides Nape and NExo, and exonuclease III (ExoIII) and endonuclease IV (EndoIV) in Escherichia coli. NExo and ExoIII are found in this subfamily. NExo is the non-dominant AP endonuclease. It exhibits strong 3'-5' exonuclease and 3'-deoxyribose phosphodiesterase activities. Escherichia coli ExoIII is an active AP endonuclease, and in addition, it exhibits double strand (ds)-specific 3'-5' exonuclease, exonucleolytic RNase H, 3'-phosphomonoesterase and 3'-phosphodiesterase activities, all catalyzed by a single active site. Class II AP endonucleases have been classified into two families, designated ExoIII and EndoIV, based on their homology to the Escherichia coli enzymes ExoIII and endonuclease IV (EndoIV). This subfamily belongs to the ExoIII family; the EndoIV family belongs to a different superfamily.	3.3704e-140
NZ_CP048836.1\|WP_173764335.1\|1234162_1235314_-\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	3.46264e-60
NZ_CP048836.1\|WP_173764327.1\|1224583_1225519_-\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|237571	PRK13961, PRK13961, phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional.	0
NZ_CP048836.1\|WP_173764328.1\|1225576_1226614_-\|hypothetical-protein	gnl\|CDD\|238863	cd01825, SGNH_hydrolase_peri1, SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	0.00376463
NZ_CP048836.1\|WP_173764331.1\|1229564_1229975_-\|gamma-glutamylcyclotransferase	gnl\|CDD\|119400	cd06661, GGCT_like, GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).	1.73687e-22
NZ_CP048836.1\|WP_173764339.1\|1238864_1240895_-\|transketolase	gnl\|CDD\|183723	PRK12753, PRK12753, transketolase; Reviewed.	0
NZ_CP048836.1\|WP_173764336.1\|1235464_1236649_-\|phosphoglycerate-kinase	gnl\|CDD\|234613	PRK00073, pgk, phosphoglycerate kinase; Provisional.	0
NZ_CP048836.1\|WP_173764333.1\|1231604_1232354_-\|5,6-dimethylbenzimidazole-synthase	gnl\|CDD\|380321	cd02145, BluB, 5,6-dimethylbenzimidazole synthase. BluB catalyzes the O2-dependent conversion of FMNH2 to 5,6-dimethylbenzimidazole (DMB), a component of vitamin B12; is is a subfamily of the nitroreductase family; nitroreductases typically reduce their substrates by using NAD(P)H as electron donor and often use FMN as a cofactor.	7.92645e-95
NZ_CP048836.1\|WP_173764338.1\|1237785_1238814_-\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|223135	COG0057, GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism].	4.58232e-171
NZ_CP048836.1\|WP_173764322.1\|1218033_1218747_-\|alpha/beta-hydrolase	gnl\|CDD\|315383	pfam12695, Abhydrolase_5, Alpha/beta hydrolase family. This family contains a diverse range of alpha/beta hydrolase enzymes.	1.31396e-05
NZ_CP048836.1\|WP_173764332.1\|1230437_1231502_-\|fructose-bisphosphate-aldolase-class-II	gnl\|CDD\|181691	PRK09196, PRK09196, fructose-bisphosphate aldolase class II.	0
NZ_CP048836.1\|WP_173764337.1\|1236696_1237725_-\|erythrose-4-phosphate-dehydrogenase	gnl\|CDD\|130595	TIGR01532, D-erythrose-4-phosphate_dehydrogenase_E4PDH., erythrose-4-phosphate dehydrogenase. This model represents the small clade of dehydrogenases in gamma-proteobacteria which utilize NAD+ to oxidize erythrose-4-phosphate (E4P) to 4-phospho-erythronate, a precursor for the de novo synthesis of pyridoxine via 4-hydroxythreonine and D-1-deoxyxylulose. This enzyme activity appears to have evolved from glyceraldehyde-3-phosphate dehydrogenase, whose substrate differs only in the lack of one carbon relative to E4P. Accordingly, this model is very close to the corresponding models for GAPDH, and those sequences which hit above trusted here invariably hit between trusted and noise to the GAPDH model (TIGR01534). Similarly, it may be found that there are species outside of the gamma proteobacteria which synthesize pyridoxine and have more than one aparrent GAPDH gene of which one may have E4PD activity - this may necessitate a readjustment of these models. Alternatively, some of the GAPDH enzymes may prove to be bifunctional in certain species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridoxine].	1.11525e-161
NZ_CP048836.1\|WP_173764330.1\|1228198_1229488_-\|DUF3422-domain-containing-protein	gnl\|CDD\|378758	pfam11902, DUF3422, Protein of unknown function (DUF3422). This family of proteins are functionally uncharacterized. This protein is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 426 to 444 amino acids in length.	0
NZ_CP048836.1\|WP_173764340.1\|1241048_1241924_-\|phosphoribulokinase	gnl\|CDD\|237970	PRK15453, PRK15453, phosphoribulokinase; Provisional.	0

>NZ_CP048836.1|WP_173764331.1|1229564_1229975_-|gamma-glutamylcyclotransferase
MDHCFTYGSLMCEDIFTAVTGLVLRPEAAVLEGYARHPVIGTDYPGVRRRDGARVPGRLYRNVSPAGVAYLDRFEGDEYRRERLEVTLCDGHTVAAWVYVFDTAQGHRLDAGPWDFEHFLREGKARFLLRHPPAPL
>NZ_CP048836.1|WP_173764330.1|1228198_1229488_-|DUF3422-domain-containing-protein
MTLFEEHPLRHALNEEVHARPSVPLTGPTRISYLAFVHANGSSDREHHHLEQLAQQLGIDLPETGKGHILIDAGDFRLKWERHTEFSSYTFFRDVPDNEPEDTTALLAVPAAWRKAIPGQLLVASHVAVLDARAYPPQQRLEGYRDPSQMWVISRFADNAGWIFTDFRIHDGFSRFTVIDERLDRRQAGRNVQRLLEIETYRLMALLAFPVAKAVGPVLTEAENELADLMDTMGRAQTPDDERDILARLTRLSAQVEQSVARTTYRFGAAAAYYRLVQQRTHELRETRYAGFPSIGDFIERRLAPAVNTCAAIAHRQEELSARVARNSQLLRTRVDIELQQQNQSLLGQMNQRAKLQLRLQETVEGLSVVAITYYASQLVNYLSKGAKPFIKPLTPEIITAVSIPVIAGLVALGLHRMRKHLAAAEAHE
>NZ_CP048836.1|WP_173764329.1|1226622_1228101_-|MBOAT-family-protein
MLFTSAAFAFLFLPITVAGFFLLPQKWRPWGASWLFVASLFFYGYWMPSYVVLLLVSIVWNYLAGMRIAAAGGRTPGGRFWLILGVTVDLLLLAYFKYAAFLVNSVAAVSGLDLGPVQITLPIGISFFTFTQIAFLADAYQKGTREYAFSHYGLFVTYFPHLIAGPVLHHAQMMPQFRDASTYRLNTGNLVGGLAIFALGLFKKVVLADGVAPYADGVFNAVHHGATPDLVEAWMGALAYTFQLYFDFSGYSDMAIGLSWMLNIRLPYNFDSPYKALSISDFWRRWHMSLSNFLRDYLYIPLGGNRKGPTRRYVNLFITMLLGGLWHGAAWTFVVWGGLHGLYLAIDHAFSALMARIAPRWTRHVIYRLAAWALTFLSVVVAWVFFRAESFTSAFRILHAMTGHLPAADQPHTILWNDGLAVATGVLWCAVLGALAFLGPNSNRIGERTLALVRERAGLRALLAGAVTTAAILLVLINETRDSLSAFIYFNF
>NZ_CP048836.1|WP_173764328.1|1225576_1226614_-|hypothetical-protein
MLRKTALFLLGALLLLVALEAVLQCLPVSTSTMVGHYIDPAIQTYPPHHRFTVATGWDLKNARTHRTNNYGFVDDRDFHPDPRAIAVIGDSFIEANMLPASARIGPQLERILGVPVYSMGVPGTSLLDYARRARFAHKTLKIERFVFVIETGDVRQMLCGSGNYDHDCIDPKTLQLREISAAPAGTLKQIVRHSALAQYLFSQLRVDPGQWLHAVKAWFAPAAAHGATGTKPKADTNPVSPALADTLITDFFAALPATTQPPLIVIGTSHARGQSARWNAADMQQLAERATAAGMPVVRLAEAFEQWQARTGLSTAVGPYDGHWNAAAHRVAAETVAAAMGHPAQ
>NZ_CP048836.1|WP_173764327.1|1224583_1225519_-|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MTSPLFESTLRSLPLLGRGKVRDIYAVDDEKLLIITSDRLSAFDVILPDPIPRKGQVLTALANFWFDRLAHVVPNQLTGIAPEDVVAADERDQVVGRALVVKRLNPLPIEAVVRGYVIGSGWKDYQLTGAICGIPLPPGLQQAAKLPAPIFTPASKAEVGDHDENISFAQAQARTEAVLAGALAGTGVTGAALTEDARRVAIQLYEEAAAYAAGRGIIIADTKFEFGIDAAGTLHLIDEALTPDSSRFWPADQYREGISPPSFDKQYVRDHLETLDWDKRAPGPHLPAEVIERTSAKYVEAYERLTGKTLP
>NZ_CP048836.1|WP_173764326.1|1223681_1224455_-|DUF2189-domain-containing-protein
MEKPADFLSQHFAIPHIREVTPQRPLDWLSRGWSDMRDNLGASVCYGLFFAVIGYALLTFAAPRPYLFTTAISGFLLVGPLAAAGLYEISRRHERGRNSSFRSSLAGLRRRADVLLHFGLLLALLLIAWERISAVVFALFYADNVPDLGNFLQSIILSGEHTALLVAYLFVGGTLAVLVFCATVIAIPMMMARDTDMLTAMATSARAVAVNPLPMLVWAVLIVALVAMGFATLMVGMVILLPLLGHASWHAYRDMVG
>NZ_CP048836.1|WP_173764325.1|1221443_1223513_-|M3-family-metallopeptidase
MSTLADNPLLDFTDLTHFDRITPAHVEPAIRHLLDDARKTIDALAQPATPATWDDFVVPMTEATEHLGRAWGVVGHMHSVMDTPDWRAAYNALLPEISRFFAELGQNQAVYEKYRQLANSTAFDRLPPVRQRIVEHELRDFRLSGAELADDRKPRFQAIQEELSSLAAGFSENLLDATNAFAEFVDDAAELTGLPDDVIAAARAAAERDGKAGWKFTLHMPSYLPVMQYADSARLRETMYRAYATRASEQGEAKWDNGPLMGRILALRAEEAKMLGFESYAELSVVPKMADSPAQVLAFLNDLAGKAKPFAERDLEELKAFARERLGMAEMHPWDVAYASEKLRHARYDFSENEVRQYFPEPRVLDGLFGVIESLYGVRLARDTAPTWDPSVTVLRIERDARLIGQLYLDLHARETKRGGAWMDSARSRQNSGGRLLTPVAYVVCNFAPPVGDKPATLSHDDVTTLFHEFGHALHHLLTEVDDVAVSGIHGVEWDAVELPSQFMENFCWEWDVVSGMSAHVDTGAPLPRALFDKMVAARHFQSGMQMVRQLEFSLFDLRLHHEVEADQPVAVETILKLLDEVRRQVAVLMPPPWHRFPHSFSHIFAGGYSAGYYSYKWAEVLSADAFAAFEEAGEGRHSLLDRDTGERFWREILAVGGSRPAIESFRAFRGREPQVEALLRHSGMLEAA
>NZ_CP048836.1|WP_173764324.1|1219664_1221476_+|EAL-domain-containing-protein
MARAKTLASVTRIEQIISTRALGFEFQPIAHLSQRTLHGFEALMRGPAGSELASPERMLEVARYAGLSLELERLSCLEAIKAFARLQLPGLLFLNASAGTIASFAEPGGGGLIATAREHGISEARLVLELTEHERVTDIDRFAGTVAVLRDAGIKLALDDFGDGRSSVRLWTQLKPELVKFDRFFVRDAHVDARKHAVLKSLFQLAEALDTPVVIEGIETREDLMVARDLGCQFAQGYLLGRPHPAPARELRTEVCAWLAQAGLASAPMPAQRRNVLETVESLLVHAPTVRPGDSCEAVLRTFGRHEDVHALAVVQDDRPIGLINRQKFTDKMSQPFHIDLFGRRPCAIFMDPNPLRVDRYSGIESLATVMLGEDQRYLTDGFIVTDGGAYAGLGTGERLVRAVTERRIEAARLANPLTCLPGNIPITDHIRRLLGAEAPFSAAYFDLNHFKPYNDLYGYWRGDEMIKLAAAVMVRHCDSRCDFLGHVGGDDFVVLFQSPDWVERCEAIIEEFNRRARCLFDDAELARGGFVSEDRRGHETFFPLTSISVGVVTVPPGCAIDPEGVASSAAAAKKAAKRAKDHFFAAGDIRRDSGRFEHAAVA
>NZ_CP048836.1|WP_173764323.1|1218743_1219505_-|exodeoxyribonuclease-III
MRIATWNVNSLKVRLPHVLDWLAAEKPDALCLQELKMEDKAFPLEALQEAGYQAIFNGQKTYNGVAILSPQPLADPVRDIPGFEDAQKRIIAGTLGDVRIICGYFPNGQAVGSEKFEYKLRWLAALTEWVRAEMAVHPKLVLTGDFNIAPEDRDAHPDWKDEIHVSAPEREAFRALTELGLTDAFRLFEQEERSFSWWDYRMGAFRRNFGLRIDHLLVSEALTGASTACWVDKAPRKLERPSDHAPVVLDLAP
>NZ_CP048836.1|WP_173764322.1|1218033_1218747_-|alpha/beta-hydrolase
MMPTGVILLHGKWDTPPFAVAPLARVLTDAGYTVRLTVWPWALRRLYDQALEQVHEGLAAQIAELRRSGCQRVVLCGHSLGGAVALAHAARHGGVDALALLAPGHFPERLADEGLTTEALAQARQAESATARMPLVDVHQGRTRRLRVAPAVYLDYFEPVGPLVWPENTRRLAPEVPMLWVVGHGDPAARLGMDYAFARTPAHRLDRYARIAADHATTPQAGAAHVMDWLRTLDTTS
>NZ_CP048836.1|WP_173764332.1|1230437_1231502_-|fructose-bisphosphate-aldolase-class-II
MPLVSMRQLLDHAAENGYGLPAFNVNNLEQVQAIMEAASETDSPVIMQASAGARKYAGEAFLRHLIDAAVEAYPHIPVVMHQDHGQSPAICMAAMRSGFSSVMMDGSLMEDGKTPSSYEYNVDVSRKVVEMAHSIGVTVEAELGCLGSLETGMAGEEDGIGAEGVLDHSALLTDPDQAADFVKQTDCDALAIAIGTSHGAYKFTRKPTGDILAIDRIKAIHQRLPNTHLVMHGSSSVPQELLEIIRQYGGDMKETYGVPVEEIVEGIKYGVRKINIDTDIRLAMTGAIRKFLAENPSKFDPREYNKPAREAAKQVCKARYEAFGCAGQASRIKPVSLEKMAALYKAGELRQVVR
>NZ_CP048836.1|WP_173764333.1|1231604_1232354_-|5,6-dimethylbenzimidazole-synthase
MQASNALHAHAFSREERATIYRNMLARRDVRSQFVPDPVDDAVLARILTAAHFAPSVGFMQPWSFVLVRDPAVKQRAHEAFTQANAEAADMFEGARREAYKSLRLEGILEAPVNLCITCDRDRDGPVVLGRTHQKAMDLYSTVCAVQNLWLAARAEGLGVGWVSIFHKAAIRDILQLPERVMPVAYLCIGHVSHFLDRPELEAAGWRARLPLDQLIHFDCWDGASPSGDALKAHLREAQALATNGCPPL
>NZ_CP048836.1|WP_173764334.1|1232614_1234060_-|pyruvate-kinase
MSRHTKIVATLGPSSSDLPVLERMVQAGVDVVRMNFSHGSADDHIARAEAIREASARAGRPVGILADLQGPKIRVGKFAGGKVTLRENADFVLDATCAEGNEQRVGLDYADLPKDVGPGDILLLDDGRLKLRVERVLGTEIHCTVKVGGVLSNNKGINRQGGGLSAPALTAKDMDDIRTAAKIGVDFVAVSFPKSAADMYMARQLLRAAGGKALLIAKIERVEAVANLEEILDASDGIMVARGDLAVEVGDAAVPALQKKMLRAARNKNKLTITATQMMESMINSPVPTRAEVSDVANAVLDGTDAVMLSAETAAGNYPVEVIEAMSRICLEAEKSNEVMLERDVLARTFTRIDQSIAMAAIWTAYHLKVKAIAALTQTGSTALWMSRLNCGVPIYALTPEKAARNQMTLYRDVYPLLMSQTHQDRDVLLWEAEQILLDQGVVEYGDMIVLTIGEPIGSSGGTNTLKIVRVGDHPAPGVTD
>NZ_CP048836.1|WP_173764335.1|1234162_1235314_-|diguanylate-cyclase
MPFPLSTLIGSRRRLVAAILLFLALDLTVLLTNLWIARHVAGDAVAINLAGRQRMLSQRMTKALLLRAQAADPVAQAIAEDEFRNAHAIFMRTLDAFAGGGQTTGSDGRPVVLDPVSDRGAAAVASTQALLAPLPASLADEQQAGLQRAADYLVEHNVEILTLMNTLTTALERDSVRRTEQLRLIQSGAFLLALANFVLIVVGLNRRFREAEEESARWQALARLDPLTGLSNRKGFFEAAARQLARAKRGQEPGSLILLDLDGFKPVNDRLGHPVGDAVLVRFAERLRLTARQSDEVARIGGDEFVLLCPGLVDAHAIDDLCRRIVEAMAELTPDELAPKQLGVSIGVASFFDHGYDIDTLIAQADHAMYEAKRGGGDRWHRP
>NZ_CP048836.1|WP_173764336.1|1235464_1236649_-|phosphoglycerate-kinase
MQVKKLQDLDVAGKRVFIRADLNVPQDEAGNITEDTRIRASIPSIQYCLDNGAAVMVTSHLGRPTEGTVGPEDTLAPIAVRLGQLLGKPVKLISDWVDGGFGVEPGQVVLLENCRCNTGEKKDDETLSKKMAALCDIYVNDAFGTAHRAQATTHGIARFAPVACAGMLMGAEIDALSKALYAPARPLVAIVGGAKVSTKLTILKTLAEKVDQLIVGGGIANTFLLAAGHNIGESLAEPEMVNEAREVMEIMKARGAEVPLPTDVVVADEVSALARANRICIDDVGAHDRILDFGPKSSARLADIIAHAGTIVWNGPVGVFEYNQFAGGTKMMASAIAHSEAFSIAGGGDTLAAIAKFDIADDVGYISTGGGAFLEFLEGKTLPAIAALEARFQD
>NZ_CP048836.1|WP_173764337.1|1236696_1237725_-|erythrose-4-phosphate-dehydrogenase
MTVRLAINGYGRIGRCFLRALYESTYRDQWQVVAINEPADLASIEYLTRFDSTHGRFPGVVDVSDDALRIDGRPIAITHATEPEQVDWAALGIDLLVECSGRYGTRDQLQRFIDAGCPRVLLSHPAQGAEEVDATTVFGINHDTLRGDERIVSNASCTTNAVVPVLALLDDSFGVDHALLTTLHSVMNDQPLIDGYHHTDLRRTRSAMQSIIPVSTGLARGVERLLPQLAGRVKAKAIRVPTLNVSAIELTLTLRQRVDAAAVNRLMAEAARGPFAGLLAYTEQAHASIDFNHDPHSAVIDGGQTLVSGDTLATLLLWFDNEWGFASRMVDVLSHWHHRWPR
>NZ_CP048836.1|WP_173764338.1|1237785_1238814_-|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MSIKVAINGFGRIGRCTLRAIYEQGLQNELEVVAINASGDLATNAHLLKYDTTHGRFATSVETEGENCIIIDGKPIPFYSTKDPKGVNWGEHGVDVLLECTGAYTSKAKAVQLLEMGAKRVLISAPGGDDVDATIVMGVNEGDLRGDMTVVSNASCTTNCLAPVAKVLSESVGIKQGLMTTVHAYTNDQVTVDVRHKDLRRARAAAANIIPTKTGAAKAVGLVLPQLKGKFDGFALRVPTLNVSLVDLTFTAERATTKEEINELMTAAANGPLKGILAVNNEPLVSSDFNHTAVSSTFDATQTRVIKAEDGSVLVKVLAWYDNEWGYSCRMVDAARAFAAAQ
>NZ_CP048836.1|WP_173764339.1|1238864_1240895_-|transketolase
MSSERNVTPPQFNPITGAIRALAMDAVQKANSGHPGAPMGMAEIAEVLWRHHLKHNPANPKWADRDRFVLSNGHGSMLIYALLHLTGYDLSIDDLKNFRQLHSKTPGHPEYGYAPGIETTTGPLGQGITNAVGMALAEKVLADEFNRPGHAIVDHRTWVFLGDGCLMEGISHEACSLAGTWGLGKLTAFYDDNDISIDGHVDGWFTDDTPKRFEAYGWQVIRDVQGHDPVAIEAAIAQAKANTAQPTLICCKTIIGAGAPNKQGGHDVHGAALGDAEIAATREHIGWHHPPFEIPAEVYAAWNAREAGASAEAEWNARLKTYRAAHPELAAEFERRMSGKLPSDWTAHVDAVLAQVTDKAETIATRKASQKSIEAFAPRLPELIGGSADLAGSNLTLWSGARGVTREHGGNYVYYGVREFGMAAIANGLSLHGGLIPYTATFLMFSEYARNALRMAALMKIRQVFVFTHDSIGLGEDGPTHQPVEQIATLRFIPNMDVWRPCDTTESTVAWACAIERADGPSSLCFSRQNLAFQPRSAAQVAAIRHGGYVLSEAGNAERGEAPHAVILATGSEVALAMEAQAKLAEVGTFVRVVSMPSTNVFDRQEAAYKASVLPARVPRVAIEAGVTDFWRKYVGLEGAVIGIDRFGESAPAGQLFKEFGITSDAVVDAVRTLVG
>NZ_CP048836.1|WP_173764340.1|1241048_1241924_-|phosphoribulokinase
MSMKHPIIAVTGSSGAGTTTVKHTFQAIFHRENVNAAIVEGDSFHRYTRDEMKQQIEEAEAQGKRGISHFGPESNRLDLLEQLFRSYGDSATGRRRCYIHDEAQSVQRGLPMGTFTEWEDLPVGTDCLFYEGLHGAVVTDEVDVARHVDLLIGVVPTINLEWIQKLHRDTRVRGYSREAVQDTVLRRMHDYVHFIVPQFSRTHINFQRVPVVDTSNPFSARDVPTLEESKVVIRFKDPRGVDFPYLLRMLHDSFMSRANTIVVPGGRLDLAMQLILTPLIWKLMERRRQWV
>NZ_CP048836.1|WP_173764341.1|1241979_1242789_-|inositol-monophosphatase-family-protein
MNNAAKRLSRARALESLVRDIAREAILPRYLKTARNRKHDGSLFTEADLESQRRFTEALPDLAPGPVLGEEMTGEEQARLWSEGKRGLWCIDPIDGTTNFANGIPFFAVSIAYFMEHKPIFGVVYNPVTDESFYAAAGAGAYLNGTELPLREPATVLRDAVAGVDFKRVSHHLGDELAVRPPYYSQRNFGSSALEWCFVAAGRLDVYIHGGQMLWDYAAGHLILAEAGGVAAALDGGDLLAGPAVKRGVVAAASPGLFTDWRAWLQNHA

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Crispr_ID: NZ_CP048836_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048836_3

1324641-1324732

Orphan

Consensus_repeat	Method
TCCTGCATGGCGGCGGCCCAGTCGTC	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP048836_3

>merge|NZ_CP048836|3|1324641-1324732|CRISPRCasFinder
TCCTGCATGGCGGCGGCCCAGTCGTCCTCGGCCGCGGCGTCGCCGCCACCCTCGGTGTCGGCCTGTTCCTGCATGGCGGCAGCCCAGTCGTC

>NZ_CP048836|3|3|1324641-1324732|CRISPRCasFinder
TCCTGCATGGCGGCGGCCCAGTCGTC	CTCGGCCGCGGCGTCGCCGCCACCCTCGGTGTCGGCCTGT
TCCTGCATGGCGGCAGCCCAGTCGTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048836.1\|WP_173764425.1\|1330501_1331500_-\|flagellar-motor-switch-protein-FliG	unknown	unknown	gnl\|CDD\|235561
NZ_CP048836.1\|WP_173764417.1\|1322654_1324049_-\|DUF839-domain-containing-protein	unknown	unknown	gnl\|CDD\|253386
NZ_CP048836.1\|WP_173764420.1\|1325797_1326361_-\|flagellar-basal-body-associated-FliL-family-protein	unknown	unknown	gnl\|CDD\|235909
NZ_CP048836.1\|WP_173764426.1\|1331496_1333173_-\|flagellar-M-ring-protein-FliF	unknown	unknown	gnl\|CDD\|235668
NZ_CP048836.1\|WP_173764424.1\|1329799_1330483_-\|flagellar-assembly-protein-FliH	unknown	unknown	gnl\|CDD\|235562
NZ_CP048836.1\|WP_173764413.1\|1320086_1320890_-\|iron-export-ABC-transporter-permease-subunit-FetB	unknown	unknown	gnl\|CDD\|377092
NZ_CP048836.1\|WP_173764414.1\|1320886_1321519_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213192
NZ_CP048836.1\|WP_173764409.1\|1316861_1317710_-\|DUF692-domain-containing-protein	unknown	unknown	gnl\|CDD\|377459
NZ_CP048836.1\|WP_173764421.1\|1326456_1327785_-\|flagellar-hook-length-control-protein-FliK	unknown	unknown	gnl\|CDD\|350657
NZ_CP048836.1\|WP_173764412.1\|1318724_1320062_-\|mechanosensitive-ion-channel	unknown	unknown	gnl\|CDD\|225803
NZ_CP048836.1\|WP_173764423.1\|1328394_1329798_-\|flagellar-protein-export-ATPase-FliI	unknown	unknown	gnl\|CDD\|274607
NZ_CP048836.1\|WP_173764428.1\|1334472_1335852_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NZ_CP048836.1\|WP_173764416.1\|1322272_1322515_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048836.1\|WP_173764408.1\|1316080_1316869_-\|putative-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|378264
NZ_CP048836.1\|WP_173764419.1\|1324763_1325774_-\|flagellar-motor-switch-protein-FliM	unknown	unknown	gnl\|CDD\|235849
NZ_CP048836.1\|WP_173764410.1\|1317753_1318017_-\|DUF2282-domain-containing-protein	unknown	unknown	gnl\|CDD\|370796
NZ_CP048836.1\|WP_173764427.1\|1333346_1334480_+\|PAS-domain-containing-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|236901
NZ_CP048836.1\|WP_173764422.1\|1327843_1328296_-\|flagellar-export-protein-FliJ	unknown	unknown	gnl\|CDD\|235563
NZ_CP048836.1\|WP_173764415.1\|1321588_1322272_+\|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|197713
NZ_CP048836.1\|WP_173764411.1\|1318170_1318728_-\|DUF1415-domain-containing-protein	unknown	unknown	gnl\|CDD\|377792

Protein	Function_ID	Function_description	E-value
NZ_CP048836.1\|WP_173764425.1\|1330501_1331500_-\|flagellar-motor-switch-protein-FliG	gnl\|CDD\|235561	PRK05686, fliG, flagellar motor switch protein G; Validated.	4.87515e-138
NZ_CP048836.1\|WP_173764417.1\|1322654_1324049_-\|DUF839-domain-containing-protein	gnl\|CDD\|253386	pfam05787, DUF839, Bacterial protein of unknown function (DUF839). This family consists of several bacterial proteins of unknown function that contain a predicted beta-propeller repeats.	1.42674e-20
NZ_CP048836.1\|WP_173764420.1\|1325797_1326361_-\|flagellar-basal-body-associated-FliL-family-protein	gnl\|CDD\|235909	PRK07021, fliL, flagellar basal body-associated protein FliL; Reviewed.	3.49835e-37
NZ_CP048836.1\|WP_173764412.1\|1318724_1320062_-\|mechanosensitive-ion-channel	gnl\|CDD\|225803	COG3264, COG3264, Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane].	9.29269e-77
NZ_CP048836.1\|WP_173764424.1\|1329799_1330483_-\|flagellar-assembly-protein-FliH	gnl\|CDD\|235562	PRK05687, fliH, flagellar assembly protein FliH.	9.09051e-49
NZ_CP048836.1\|WP_173764413.1\|1320086_1320890_-\|iron-export-ABC-transporter-permease-subunit-FetB	gnl\|CDD\|377092	pfam03649, UPF0014, Uncharacterized protein family (UPF0014).	6.07514e-91
NZ_CP048836.1\|WP_173764426.1\|1331496_1333173_-\|flagellar-M-ring-protein-FliF	gnl\|CDD\|235668	PRK06007, fliF, flagellar basal body M-ring protein FliF.	0
NZ_CP048836.1\|WP_173764414.1\|1320886_1321519_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	6.66656e-38
NZ_CP048836.1\|WP_173764409.1\|1316861_1317710_-\|DUF692-domain-containing-protein	gnl\|CDD\|377459	pfam05114, DUF692, Protein of unknown function (DUF692). This family consists of several uncharacterized bacterial proteins.	2.10425e-126
NZ_CP048836.1\|WP_173764421.1\|1326456_1327785_-\|flagellar-hook-length-control-protein-FliK	gnl\|CDD\|350657	cd17470, T3SS_Flik_C, C-terminal domain of flagellar hook-length control protein FliK and similar domains. The flagellar hook-length control protein FliK is a soluble cytoplasmic protein that is secreted during flagellar formation. It controls hook elongation by two successive events: by determining hook length and by stopping the supply of hook protein. It contains an N-terminal domain that determines hook length and a C-terminal domain that is responsible for switching secretion from the hook protein to that of the filament protein, by interacting with FlhB, the switchable secretion gate.	2.52068e-26
NZ_CP048836.1\|WP_173764415.1\|1321588_1322272_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197713	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor.	4.2454e-13
NZ_CP048836.1\|WP_173764423.1\|1328394_1329798_-\|flagellar-protein-export-ATPase-FliI	gnl\|CDD\|274607	TIGR03496, FliI_clade1, flagellar protein export ATPase FliI. Members of this protein family are the FliI protein of bacterial flagellum systems. This protein acts to drive protein export for flagellar biosynthesis. The most closely related family is the YscN family of bacterial type III secretion systems. This model represents one (of three) segment of the FliI family tree. These have been modeled separately in order to exclude the type III secretion ATPases more effectively. [Cellular processes, Chemotaxis and motility].	0
NZ_CP048836.1\|WP_173764428.1\|1334472_1335852_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	1.92359e-179
NZ_CP048836.1\|WP_173764408.1\|1316080_1316869_-\|putative-DNA-binding-domain-containing-protein	gnl\|CDD\|378264	pfam09836, DUF2063, Putative DNA-binding domain. This family represents the N-terminal part of a Neisseria protein, UniProtKB:Q5F5I0, Structure 3dee. It runs from residues 31-117 as a helical bundle with 4 main helices. \From genomic context and the fold of the C-terminal part, it is suggested that this protein is involved in transcriptional regulation.	2.19482e-20
NZ_CP048836.1\|WP_173764419.1\|1324763_1325774_-\|flagellar-motor-switch-protein-FliM	gnl\|CDD\|235849	PRK06666, fliM, flagellar motor switch protein FliM; Validated.	2.66354e-166
NZ_CP048836.1\|WP_173764410.1\|1317753_1318017_-\|DUF2282-domain-containing-protein	gnl\|CDD\|370796	pfam10048, DUF2282, Predicted integral membrane protein (DUF2282). Members of this family of hypothetical bacterial proteins and putative signal peptide proteins have no known function.	1.54338e-18
NZ_CP048836.1\|WP_173764427.1\|1333346_1334480_+\|PAS-domain-containing-sensor-histidine-kinase	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	2.44397e-59
NZ_CP048836.1\|WP_173764422.1\|1327843_1328296_-\|flagellar-export-protein-FliJ	gnl\|CDD\|235563	PRK05689, fliJ, flagella biosynthesis chaperone FliJ.	2.75718e-20
NZ_CP048836.1\|WP_173764411.1\|1318170_1318728_-\|DUF1415-domain-containing-protein	gnl\|CDD\|377792	pfam07209, DUF1415, Protein of unknown function (DUF1415). This family consists of several hypothetical bacterial proteins of around 180 residues in length. The function of this family is unknown.	3.32596e-98

>NZ_CP048836.1|WP_173764417.1|1322654_1324049_-|DUF839-domain-containing-protein
MVKPLALAVFGVFASAQAFAAGNTLFDELDPLTAPSSAVSVADEATQALLLSTAPGITVTQSTLASRSTVGSLSDINVGRYWDMIDTNRTGADQGRYLFMPFEPSNQSGANTGSGALRYDKLTGATTTIVAVGTQNWQRGDASRWAPWGGWMTGEENFNGVAGSATGRLFEVTNPVTATATTLTNGNGNLVQRNTMLPLVSHEGLAFDSANNFYFIDENSGGSFYKFVSANPNAANGDDFFANGTTYALQVGTGSNADVGGSFNWVDIGVSGAGQDGRTLADAAGATAFNRPEDMEVFTLGNGHEAIAFNATGTHTTWTVDLSDMSITELVTRNTIDVATGLAVGSDFTSPDNIAIDADGNLYIVEDQGVPNADIWQVIDSDGDGVAEGVKRWAALQVAGAEPTGLFFDPYDPNTAYLNIQHPGSDNDRLMKISVSAVPEPESYAMLLAGLGLVGAIARRRRAA
>NZ_CP048836.1|WP_173764416.1|1322272_1322515_-|hypothetical-protein
MKAIVNFYRSPARTGIKILVTSLVLGTLSALPLWLTLQFGDADGGATRVALLAMFGTLAGGLGAIVGVLWFGLELVFRRR
>NZ_CP048836.1|WP_173764415.1|1321588_1322272_+|helix-turn-helix-transcriptional-regulator
MRDMPHIAPVAALIGDAARADMLTALMADRALTATELAMVAGVTRQTASAHLAKLCEAGLVIMQRQGRHRYFRLSGHDVAVLIEALMGVAFRTGAVRPRAPVRAPALRKARLCYDHMAGDLAVAAFEAMLMRGWFCARPGELALSGFGRTALVALGVDAAGLEAGRRVTCRMCADWGEGRQHLAGALGARVLDHVLEAGWAVRDPDSRALRFSAAGEAAFRSAFLLD
>NZ_CP048836.1|WP_173764414.1|1320886_1321519_-|ATP-binding-cassette-domain-containing-protein
MTASHPDLPTDTEAALRVVQVAVGPLQPTDFSIAPGRVTALSGPSGSGKSRLLRALADLDAHDGEVWLGPTCQSRTPAHQWRRRVMLVPADSQWWADTVGEHLPDPARVDWAPLGFEPAVADWQISRLSSGERQRLALLRAVAHGPQALLLDEPTANLDAETTRQVEQWLLELIRTHGWPTLWVSHDRAQVERVADHHLRIDGHTLAEVA
>NZ_CP048836.1|WP_173764413.1|1320086_1320890_-|iron-export-ABC-transporter-permease-subunit-FetB
MNVIDLSVGQLGLAATLVIALAASTWALRLEMGRTVLVGALRTVVQLSLIGVVLEALFAVAALPWIALMALVMLLMAGREVNARQKYRLAGGWGFGIGTLSMFISAFSVTVLTLVAVVQPAPWYEPQYAIPLLGMMLGNTMTGVALGLDRLTDAVWRQRALIENRLMLGARWQEAVGDARRDAMRSGLIPIVNSMAAAGIVSLPGMMTGQILAGAAPAVAVKYQILIMFTITVGTGFGTMAAVMAASRRLFDERERLRLDRLATRSR
>NZ_CP048836.1|WP_173764412.1|1318724_1320062_-|mechanosensitive-ion-channel
MPDAFETLIAQLPLVGEQLARAEVQHELLALVLAGVLALVAHHLARRALTRRAEATRQGSLHHLAIRSLQRVLWPVSMLVVVFVARIALQARPQATPVLDVAVPLLTSLATIRIGVYLLRKGFRVTRALKAWENLFVIGIWSAVALHLLGWLPAVAAALDAVAFTMGETRISLLATIKLFGLIALLLTLAFWISGVIERRMRASPNMTPSLQVAFAKFARVFLIALAFLVAIDAVGIDLTTFAVFGGALGVGIGFGLQRITSNFISGFILVLDRSIKPGDVISVGTDGSKYGWVQELRARYVVVRDRDGVERLIPNENLITSEVINWSYTDKNTRIRLPVQISYDDDPEQAIALLEAAAQASPRVLGDPVPTARLLAFGDNGIELELRVWIADPENGIGNVRTDINLAIWRAFKAAGITIPYPQRDVHLKPAPPGRALPDLDPNP
>NZ_CP048836.1|WP_173764411.1|1318170_1318728_-|DUF1415-domain-containing-protein
MTPEAVIAATRHWVETVVVDLNLCPFAKRELVRDRIRFVVSEADDADTLVDDLERELQWLQDNDAVETTLLIHPQALTDFDDYNQFLDVADVLLSQMRLSGELQVASFHPDYQFAGTEADDVENTTNRSPYPMLHLIREASLEAAVMNYPDPENIPARNIETVEALGAEHMRALLQACFARGKAI
>NZ_CP048836.1|WP_173764410.1|1317753_1318017_-|DUF2282-domain-containing-protein
MNTRQILITAALAGVAAASALPAHAADAGKEKCFGIAKAGANDCASVTGTHSCAGQASRDNDPKEWKYVAKGTCADMGGSLKPGGKQ
>NZ_CP048836.1|WP_173764409.1|1316861_1317710_-|DUF692-domain-containing-protein
MAFTAHPLRGVGVGLRAAHYRDFLAQRPVVDWLEVHSENYFAAGGWDLHVLERLRPDYPLSLHGVGLGIGSASAAHFAAHLARIRTLARRVEPALISEHLCWAAVPGRHLNDLLPLPLTTEALHLVCARVDQAQAVLGHLLLENVSTGLRFAADTLAETEFLAEVARRTGCGVLLDVNNLYVNECNHGEAARAAMEAIRPGTVGEIHLAGHRVTEDAVIDHHGAPVAEVVWALYRASLERFGDVPTLIEWDTELPALPVLLAEAARAREVRTVVLATEATHV
>NZ_CP048836.1|WP_173764408.1|1316080_1316869_-|putative-DNA-binding-domain-containing-protein
MSELAELQTRFAAGLLDADETPAALFRGDAGLAARRFALYRGNLTAHWDRALGNACPVIRQMLGDDFFRAMARAFGRAHPHAEGDLNRFGAALPDFLAGFAPVADYPYLPDMARLEWALHVAHGAADAPAIDAPWLAALDVAGLDGIRLDLHPAVALMRSEWAIDALWLAHQPDGPPWPDPLARACHVAVCRPRWRAQVQPLSAGEHAALSAIARGLPLGAALETGLTAEPGFDPGQALPRWLLAGLLIAHPDHSHDKDITP
>NZ_CP048836.1|WP_173764419.1|1324763_1325774_-|flagellar-motor-switch-protein-FliM
MSADFLSQDEVDALLRGVTGETEESDADDGDEGGVRPYNLGTQERIVRGRMPTMELINERFARYLRIGLFNFMHRNAEISVGSIKVQKYSEFVRNLVVPTNLNLVNARPLRGTGLVVFDPNLVFLVVDNMFGGDGRFHTRVEGRDFTATEQRIIMGMLETVFAEYERAWAPVYKLKLEYLRSEMNSQFANIATPSEIVVSTAFSLELGGAQADMHICFPYSMLEPIRETLYSTMQSDHITQDKRWIGTMTKQIKSAPVELTVNLGQATVTLRDIVNMRVGDVIPIEVPEAIRAEVDGVAVLEGRYGVQNGQYAIRVERMIPPEDTNEPPPPGENHG
>NZ_CP048836.1|WP_173764420.1|1325797_1326361_-|flagellar-basal-body-associated-FliL-family-protein
MSKAAAKPEAEGEAPPKKGGKKLLIIILVVVLLLVVAGGAVVVLLLKKNQGEDGATDAHAKEETHLKVDLSHPPTFVTLEPFTVNLAPAEGDHFLQVVMVLKVVDPEVAEQMKGYMPEIRHEVNLVLSSKLPSEISTVDGREELAKEAMERINYVLGFEKPSAEQMKRNPGPWGPVISVLFNSFIVQ
>NZ_CP048836.1|WP_173764421.1|1326456_1327785_-|flagellar-hook-length-control-protein-FliK
MAAMVKQTLTQMLQATPTPSKGAGARGSEGNGATQETFSNTLERKMAAPERPPEARAQARQNADKPQENQPVQDKAPESAQTADAPGRDEAPAADGKQAQADGDTKAATKDTQASDDSKTAAAADAATSTTPAADPAVDPATVIAAPAAVAATPAKDAALPAADANSGAAVAATASGNRKATTVVDLTARVSDDAAKTATDPSGDRPGKDAGLTGAQARAADADTNTDLRTKPAPIRDGIANFAAQLDKQLGTAKPGDAIQMNTPGAASPGVNAHAALAAAAPSQTAQAARLSQPVLPTHLGTPVDSADWPDAVGNRVMWMAGKDESRAELILTPPSLGKLEISLHMSGDTTTAHFTAATPAAREALEQAMPRLREMLEQAGVMLADSNVNTAPQDQPGERGQGGQFHGGRHGAGGELAVGAVGTPAGHWISRGEGMIDTFA
>NZ_CP048836.1|WP_173764422.1|1327843_1328296_-|flagellar-export-protein-FliJ
MTKPFPLQTLLDMANSRMDDAARRLGELIANETEDCRKLELLENYRAEYQAKFAEALRNGIDPQAMRNYSLFIGKLDEAIAAQRDTVTQSKQRTVKGQQAWMDQRTRAKAFDALSKRHQAKEARDELKREQRMTDEHASKQFRDRQSDDE
>NZ_CP048836.1|WP_173764423.1|1328394_1329798_-|flagellar-protein-export-ATPase-FliI
MERHTDTWRRFLSDAQRLAGATSPFQMSGRLTRINGLVMEAAGLKLPLGSGCRIVVPGGGSVEAEVVGFNGERIYMMPTDDVFGLAPGAQVLPIEPVQPKLIAGQRTVPRRRASDRAKHLPLDDALLGRVVDGAGRPLDGLGPLEAEHSRSLQSRPFNPLQRAPISQSLDVGIRAINALLTIGRGQRMGLFAGSGVGKSVLIGMMARYTKADVIVVGLIGERGREVKEFIEQNLGEEGRARSVVVAAPADTSPLMRLQGAAYATTIAEYFRDQGKQVLLIMDSLTRYAMAQREIALAIGEPPVTRGYPPSVFARLPALVERAGNGPDGGGSITAFYTVLAEGDDQQDPIADSARAILDGHIVLSRALADQGHYPAIDIEQSISRAMHNLVKPAHFEHVRKFKQLFSRYQRSRDLIAVGAYQPGSDPVLDQAVEAYPALEAYLQQAIDEREGYEDAVAKLHRLFGDEI
>NZ_CP048836.1|WP_173764424.1|1329799_1330483_-|flagellar-assembly-protein-FliH
MSFHRNQAAGAYRRWDPPSFDAPPEPEPAPVELDSPEPPPEPETFEPEADAEPPFKLPTAEDIERIHDEARKEGYAAGYEEATARGRMEALQLHTLVENLDAAMTQLDQDVAEEVLALSLEVARQMVQHSMHEHPAMVVDVVREALHHLPQGRALIHLNPEDASLVREYLGEQLKHNEHRLVEDDTVARGGCRVEAAGSMVDATVQTRWRRIMENLGRDDTEWEAQD
>NZ_CP048836.1|WP_173764425.1|1330501_1331500_-|flagellar-motor-switch-protein-FliG
MSAEDGTEKGALLLLSLGSDEAAEVLKHLGPKEVQKLGLTMAKLPSHPRSKVEPLLDELETHSEKGSPIEANEEEIRAMLTKALGDDRAAHIISRVLQGSDTAGIESLKWMDAATAADLIKNEHPQIIATILVHLEYDQAGEILKHFTDRLRNDVVLRIATLDGVQPTALKELNDALSRTLSGASTVKKAAMGGVRHAADILNFVGAAAETAVIDNVREYDPDLAQKILDEMFVFDNLMDIDDRGIQTILREVQSDSLVVALKGATEEMREKIFKNMSQRAAEMLREDLESRGPVRLSEVEAEQKEILKIVRRLAEEGQIMLGGKGGDDAFV
>NZ_CP048836.1|WP_173764426.1|1331496_1333173_-|flagellar-M-ring-protein-FliF
MATAQDAAAAGASPLQQAFQNFNALPARQKLAMMAALAAAIALAVGVLLWSRTPDYAVLFSNLEERDGGAIVTALQQQNVPYKFGAGGAAIMVPADRVHDIRLQLAAQGLPRGGLVGFELMENQKLGVSQFHEQINYQRGLEGELARTIQSISSVAGARVHLAIPKRTAFLRDAKQPTASVFVNLYPGRNLDAAQVAGIVHLVAASVPNMSNDDVSVIDETGKLLTNKADPLRAAGLDPTQISYVQELEDTYARRVDTILEPLVGKGNFRVQVAADVDFNRVEQTDEIYKPNPEPDQAIRSQQKSEAITRDPNAKGVPGALSNQPPVPATAPITNPASGTATTQDNFQTKNTSVTTNYEVDKTISHTRHAMGAIKRLSVAVLVNHRKQTDRNGKETMVAPSDAELERINKLVREAVGFNAARGDTLNVAASAFAPETFETAPALPIWKDPDMIAMAKEALRYLILAAVLAYVAFGVIKPLMKSITPPPRAAGDEEEDAAMAEGEEGEEGARTTLSHAAQVASSYEAKLARARELAKGDPKMVANLIKEWMGVNEEARK
>NZ_CP048836.1|WP_173764427.1|1333346_1334480_+|PAS-domain-containing-sensor-histidine-kinase
MTETTTPPLNAAQLAEAFEQFNRVSAELTEAYAGLQGQVAQLNERLSVLMTALPAGVVVLDREGCVVQINRAASAWLGEDLDGQPWAMASTRFTATETPGEMELEAAPGAAPRRIALSATALDSGEGSIVLMHDVTDTHRMQREAERNARLAAMGEMVAGLAHQLRTPLSAALLYTSSLGKPQLAGEERTRVAGRAVERLRHLERLIRDMLLFARGDCLGREPVPVCALVEELAHTLEPIARERGIDFEHACGCGQTRLVADRKALAGALTNLLENALQFTPESGQVRLDAQRDGRQVVFTVSDTGKGIAPEQQQRLFEPFFTTRAEGTGLGLAIARGVARAHGGDIDLTSRPEAGTTFRLSVPLAAEGDDNETPHE
>NZ_CP048836.1|WP_173764428.1|1334472_1335852_+|sigma-54-dependent-Fis-family-transcriptional-regulator
MSEALNLLLVEDDDALRDAVGLTLEMEGHQVTAVDGGPAALEALEHGVFNLVVSDLKMDPMDGLTLLGEIRARLPQLPVMLMTAFGDVEKAVSAMQGGACDFLLKPFEPEVLLAHVRRYATPVASGDGTIAEDARTRELTALAARVAETDATVLLTGESGTGKEVFARYIHAHSPRRAKPFVAINCAAIPDNLLEATLFGYEKGAFTGAQTAQAGKFEQADGGTLLLDEISEMPLGLQAKLLRVLQEREVERVGGKKPIHLDIRVLATSNRDMVAEVAAGRFREDLYYRLNVFPLAIPALRERPGDIIALGRHFLARHGERIGRQASLAADAAELMVRYPWPGNARELDNAMQRALILATGGVIGADTLRLCLGHTPTIGASPGVAASAAAEAANLAAVAPAPPAGSATNMKDLEREHILSTLRAVGGSRKKAVEKLGISERTLRYKLQQYREEGHSID

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Crispr_ID: NZ_CP048836_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048836_4

3263157-3263305

Orphan

Consensus_repeat	Method
CTGCAGTTCCTCGTTGGAGGCCT	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP048836_4

>merge|NZ_CP048836|4|3263157-3263305|CRISPRCasFinder
GGTCAGCTCTTCGTTGGAGGCCTGCAGTTCCTCGTTGGAGGCCTGCAGCTCCTCGGTCGATGCCTGCAGTTCCTCCTGCATGGACTGCAGTTCCTCGTTGGAGGCCTCGAACTTGTCGATCACCGCCTGCAGATGCTCGCGGGTGTCCG

>NZ_CP048836|4|4|3263157-3263305|CRISPRCasFinder
GGTCAGCTCTTCGTTGGAGGCCT	GCAGTTCCTCGTTGGAGGC
CTGCAGCTCCTCGGTCGATGCCT	GCAGTTCCTCCTGCATGGA
CTGCAGTTCCTCGTTGGAGGCCT	CGAACTTGTCGATCACCGC
CTGCAGATGCTCGCGGGTGTCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048836.1\|WP_173766886.1\|3256305_3260151_+\|SIR2-family-protein	unknown	unknown	gnl\|CDD\|238697
NZ_CP048836.1\|WP_173766901.1\|3270467_3271247_-\|enoyl-ACP-reductase-FabI	unknown	unknown	gnl\|CDD\|181020
NZ_CP048836.1\|WP_173768839.1\|3267121_3267610_+\|TIGR00645-family-protein	unknown	unknown	gnl\|CDD\|179964
NZ_CP048836.1\|WP_173766890.1\|3265413_3266073_-\|DsbA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|239322
NZ_CP048836.1\|WP_173766905.1\|3271983_3273555_-\|alkyl-hydroperoxide-reductase-subunit-F	unknown	unknown	gnl\|CDD\|237942
NZ_CP048836.1\|WP_173766878.1\|3251646_3252342_+\|F0F1-ATP-synthase-subunit-A	unknown	unknown	gnl\|CDD\|237382
NZ_CP048836.1\|WP_173766903.1\|3271413_3271938_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380121
NZ_CP048836.1\|WP_173766892.1\|3266123_3267002_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048836.1\|WP_173766893.1\|3267609_3267837_+\|oxidoreductase	unknown	unknown	gnl\|CDD\|370696
NZ_CP048836.1\|WP_173766876.1\|3251353_3251650_+\|AtpZ/AtpI-family-protein	unknown	unknown	gnl\|CDD\|378198
NZ_CP048836.1\|WP_173766897.1\|3269359_3269848_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP048836.1\|WP_173766874.1\|3250961_3251357_+\|F0F1-ATP-synthase-subunit-epsilon	unknown	unknown	gnl\|CDD\|213395
NZ_CP048836.1\|WP_173766870.1\|3246874_3249232_-\|TonB-dependent-siderophore-receptor	unknown	unknown	gnl\|CDD\|227115
NZ_CP048836.1\|WP_173766882.1\|3252868_3253618_+\|F0F1-ATP-synthase-subunit-delta	unknown	unknown	gnl\|CDD\|132364
NZ_CP048836.1\|WP_173766883.1\|3253607_3255053_+\|F0F1-ATP-synthase-subunit-alpha	unknown	unknown	gnl\|CDD\|183987
NZ_CP048836.1\|WP_173766880.1\|3252338_3252605_+\|ATP-F0F1-synthase-subunit-C	unknown	unknown	gnl\|CDD\|184067
NZ_CP048836.1\|WP_173766895.1\|3267820_3269200_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NZ_CP048836.1\|WP_173766885.1\|3255049_3255982_+\|F0F1-ATP-synthase-subunit-gamma	unknown	unknown	gnl\|CDD\|213394
NZ_CP048836.1\|WP_173766899.1\|3269860_3270457_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048836.1\|WP_173766872.1\|3249576_3250965_+\|F0F1-ATP-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|183615

Protein	Function_ID	Function_description	E-value
NZ_CP048836.1\|WP_173766886.1\|3256305_3260151_+\|SIR2-family-protein	gnl\|CDD\|238697	cd01406, SIR2-like, Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation.	2.2645e-39
NZ_CP048836.1\|WP_173766901.1\|3270467_3271247_-\|enoyl-ACP-reductase-FabI	gnl\|CDD\|181020	PRK07533, PRK07533, enoyl-[acyl-carrier-protein] reductase FabI.	4.8832e-136
NZ_CP048836.1\|WP_173768839.1\|3267121_3267610_+\|TIGR00645-family-protein	gnl\|CDD\|179964	PRK05208, PRK05208, hypothetical protein; Provisional.	8.85992e-85
NZ_CP048836.1\|WP_173766890.1\|3265413_3266073_-\|DsbA-family-oxidoreductase	gnl\|CDD\|239322	cd03024, DsbA_FrnE, DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins.	1.60868e-64
NZ_CP048836.1\|WP_173766905.1\|3271983_3273555_-\|alkyl-hydroperoxide-reductase-subunit-F	gnl\|CDD\|237942	PRK15317, PRK15317, alkyl hydroperoxide reductase subunit F; Provisional.	0
NZ_CP048836.1\|WP_173766878.1\|3251646_3252342_+\|F0F1-ATP-synthase-subunit-A	gnl\|CDD\|237382	PRK13420, PRK13420, F0F1 ATP synthase subunit A; Provisional.	1.24028e-101
NZ_CP048836.1\|WP_173766893.1\|3267609_3267837_+\|oxidoreductase	gnl\|CDD\|370696	pfam09791, Oxidored-like, Oxidoreductase-like protein, N-terminal. Members of this family are found in the N terminal region of various oxidoreductase like proteins. Their exact function is, as yet, unknown.	2.73235e-09
NZ_CP048836.1\|WP_173766876.1\|3251353_3251650_+\|AtpZ/AtpI-family-protein	gnl\|CDD\|378198	pfam09527, ATPase_gene1, Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter. This model represents a protein found encoded in F1F0-ATPase operons in several genomes, including Methanosarcina barkeri (archaeal) and Chlorobium tepidum (bacterial). It is a small protein (about 100 amino acids) with long hydrophobic stretches and is presumed to be a subunit of the enzyme. It carries two transmembrane helices and is a magnesium or calcium uniporter. The atp operon of alkaliphilic Bacillus pseudofirmus OF4, as in most prokaryotes, contains the eight structural genes for the F-ATPase (ATP synthase), which are preceded by an atpI gene that encodes a membrane protein with 2 TMSs. A tenth gene, atpZ, has been found in this operon, which is upstream of and overlapping with atpI.	1.00732e-09
NZ_CP048836.1\|WP_173766897.1\|3269359_3269848_+\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.32202e-07
NZ_CP048836.1\|WP_173766874.1\|3250961_3251357_+\|F0F1-ATP-synthase-subunit-epsilon	gnl\|CDD\|213395	cd12152, F1-ATPase_delta, mitochondrial ATP synthase delta subunit. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to drive ATP synthesis and hydrolyzes ATP to build the proton gradient. The extrinisic membrane domain, F1, is composed of alpha, beta, gamma, delta, and epsilon subunits with a stoichiometry of 3:3:1:1:1. Alpha and beta subunit form the globular catalytic moiety, a hexameric ring of alternating subunits. Gamma, delta and epsilon subunits form a stalk, connecting F1 to F0, the integral membrane proton translocating domain. In bacteria, which is lacking a eukaryotic epsilon subunit homolog, this subunit is called the epsilon subunit.	1.28981e-13
NZ_CP048836.1\|WP_173766870.1\|3246874_3249232_-\|TonB-dependent-siderophore-receptor	gnl\|CDD\|227115	COG4774, Fiu, Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism].	1.32483e-121
NZ_CP048836.1\|WP_173766882.1\|3252868_3253618_+\|F0F1-ATP-synthase-subunit-delta	gnl\|CDD\|132364	TIGR03321, alt_F1F0_F0_B, alternate F1F0 ATPase, F0 subunit B. A small number of taxonomically diverse prokaryotic species, including Methanosarcina barkeri, have what appears to be a second ATP synthase, in addition to the normal F1F0 ATPase in bacteria and A1A0 ATPase in archaea. These enzymes use ion gradients to synthesize ATP, CC and in principle may run in either direction. This model represents the F0 subunit B of this apparent second ATP synthase.	3.77177e-31
NZ_CP048836.1\|WP_173766883.1\|3253607_3255053_+\|F0F1-ATP-synthase-subunit-alpha	gnl\|CDD\|183987	PRK13343, PRK13343, F0F1 ATP synthase subunit alpha; Provisional.	0
NZ_CP048836.1\|WP_173766880.1\|3252338_3252605_+\|ATP-F0F1-synthase-subunit-C	gnl\|CDD\|184067	PRK13468, PRK13468, F0F1 ATP synthase subunit C; Provisional.	3.35065e-24
NZ_CP048836.1\|WP_173766895.1\|3267820_3269200_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	1.25768e-102
NZ_CP048836.1\|WP_173766885.1\|3255049_3255982_+\|F0F1-ATP-synthase-subunit-gamma	gnl\|CDD\|213394	cd12151, F1-ATPase_gamma, mitochondrial ATP synthase gamma subunit. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to drive ATP synthesis and hydrolyzes ATP to build the proton gradient. The extrinisic membrane domain of F-ATPases is composed of alpha, beta, gamma, delta, and epsilon (not present in bacteria) subunits with a stoichiometry of 3:3:1:1:1. Alpha and beta subunit form the globular catalytic moiety, a hexameric ring of alternating subunits. Gamma, delta and epsilon subunits form a stalk, connecting F1 to F0, the integral membrane proton translocating domain.	7.14341e-06
NZ_CP048836.1\|WP_173766903.1\|3271413_3271938_+\|hypothetical-protein	gnl\|CDD\|380121	pfam18143, HAD_SAK_2, HAD domain in Swiss Army Knife RNA repair proteins. Family of HAD domain phophoesterases observed in large eukaryotic proteins with predicted role in RNA repair, the so-called 'Swiss Army Knife' repair proteins. May be involved in phosphate group removal during RNA re-ligation.	1.56534e-29
NZ_CP048836.1\|WP_173766872.1\|3249576_3250965_+\|F0F1-ATP-synthase-subunit-beta	gnl\|CDD\|183615	PRK12597, PRK12597, F0F1 ATP synthase subunit beta; Provisional.	0

>NZ_CP048836.1|WP_173766886.1|3256305_3260151_+|SIR2-family-protein
MQFVTDGPDIPDELLQAHEEGRVVFFCGAGISYPAGLPGFKGLVEQIYQLNGTTLSVIEREAFDRGQFDATLDLMERRLPGQRLALRRALAQVLKPKLRRKGATDTQAALLRLARSREGALRLVTTNFDRIFQVAAKRTDQAFQAYPAPMLPIPKNSRWDGLVYLHGLLPEKTDDTALNRLVVTSGDFGLAYLTERWAARFVSELFRNYVVCFVGYSINDPVLRYMMDALAADRMLGEITPQAWALGDCEPGQEHRKTIEWEAKGVTPILYTVPAESYDHSALHQTLHAWADTYRDGVQGKEAIVVKHALARPQDSTRQDDFVGRMLWALSDKSGLPAQHFADLNPVPPLDWLLEAFSDERFQYSDLPRFHIPPHDEVDSRLRFSLIRRPAPYDRAPPMLLASGGVNGSQWDDVMFHLARWLVRHLDDPRLIIWIAERGGQMHDRWPWLIEHELDRFAALERDGKTFERDEILLHAPKAIPGPLMRALWRLLLSGRVKSPWHDPDLYRWQGRLNREGLTATVRLELRELLAPKVVLKKPFRWSDDDSNSSGEPVRVKQLVDWELVLAADHVHSTLRDLADEPWKSALPHLLEDFQQLLRDALDLLRELGEADDRSDRSHWDLSSITPHWQNRGFRDWVSLIELLRDAWLAVRANDSTRATRIAQTWFDLPYPTFKRLALFAASHDDCIPPEQWVGWLLADDAWWLWTVDLGREVFRLFVLQGRRLAGAAQERLEAAILAGPPREMYRDDLEADRWQDLVARSVWLHLAKLNASNIVLGASAAARLAEISKAYPQWQLATNERDEFSHWMSGTGDPDYEDSRDVDIAPRKRQELVQWLTKPMPERRPFYEDTWREVCRSRFFHSLSALCDLARTNVWPAGRWREALQAWAEEGMVLRSWRYAAPLVQNMPDDVLQEIDHAVTWWMDAASKSISRHEDILLNLCRRVLALPLETGSGSRIIRNGVETYDPVGSAINHPIGHATQALINLWFKQNPNDNDLLPADLKRIFTALCDVQVDRFCHGRVLLGSRLIAFFRVDRPWTEQHLLPLFGWSNPVEAKAVWEGFLWSPRLYQPLMTAFKSQFLDSANRYADLGEHRQQFATFLTYAALGPTEGYTAEEFRSAIGTLPQEGLEESAQALTQALEGAAGQREDYWKNRAQPFWQQVWPKSRDLATPRIAESLTRLVIAARGEFPAALVAVQDWLQPIDHPDYVVHLLHESGLCRQFSAEALQLLNAVIYDQQWGPRELGKCLDEIVQAAPQLAQDGRYLRLREYSRRRGIQGSR
>NZ_CP048836.1|WP_173766885.1|3255049_3255982_+|F0F1-ATP-synthase-subunit-gamma
MSKRRELVRHIDSLTDIGELLGAMRSLALAESRRIATFIDAQRDSATIVRQAYAQVLHDHGHHWQQPAIHGRVVCVIGTERGFCGDLNQRLVADALGTTADTEATRWLLIGTRLADAWPADAPTPEARLGGAGMADEVLAVQTALVAALTPCSPNAPTPCPHWSSTTRGPTASPTSPSCPSPPAPRPCHRAATRWTSTSPRPPCRPPCSTNTSTWPSAASCSKPCCTKTNNASPTWTRPDATWTTASTPWAAAPTGRVRRRSRRRSRSSCWRGRWRGKERRGERQDVGPLLPLAYIARIACNALLTCLQL
>NZ_CP048836.1|WP_173766883.1|3253607_3255053_+|F0F1-ATP-synthase-subunit-alpha
MPVEAAPLDYRPALRVIERGRVSSVGDGIVWIEGLPSARMDGIVKIDDGSEALVFHLTPERLGAILLISTPALMAGCEARLSDEALTMPATDALLGRVVDPLACPLDDGGPVEGNGHRPVDGPSPPIVARDFVDRPLYTGSKVVDTLIPIGRGQRQLLIGDNGTGKSALALDAVIAQRDQGVRCVYVLIGQKRSSVVQTIDTLRAHDALAFTTLVVAEATASPGIKYLAPFAGCAIAEGWMAAGHDTLVVYDDLTTHARAYRELSLLLRRPPGREAYPADIFYLHARLLERSTRLAAEHGGGSMTALPIAETEQGEIAAYIPTNLISITDGQIHFDAALFARGVLPAIDITRSVSRIGGKAQHEAIGREAGRMKLDYLQFLELEVFTRFGAKLDAGMSARIARGRLLRAILAQDRLDPHTPRDQLAWMIACNENRLDGLDGDALHTTLTQLRDAVAASELTLDSPRQDWLDAVRRTLGHAP
>NZ_CP048836.1|WP_173766882.1|3252868_3253618_+|F0F1-ATP-synthase-subunit-delta
MQLDWTTFLLQIINFLVLVWLLKRFLYRPVMDVIARRQAAIDQSVADARATEANARSLRADYEARLAELDTQHARQLAKLADEIAQERQRRMDRLDADMATEREKRAALAEHEAAERQRKADMAAHRQASAFVSRLLGRLGDAHLDRRLLDMLIDDLPHLPAHQRDGLREAAAAPDAQLRVTSARPLDASARHALESALAEPAGRPLGADYATDDTLLAGVRVTLGPWLLAATLADELDYFRAGARHAG
>NZ_CP048836.1|WP_173766880.1|3252338_3252605_+|ATP-F0F1-synthase-subunit-C
MSDMTYFTSLSTVGALFAIALGVFFPALAMGRAISQALDAIARQPEAEKSISRLLFIGLAMIESLAIYVLVVVLIVLFRNPLLEYLVK
>NZ_CP048836.1|WP_173766878.1|3251646_3252342_+|F0F1-ATP-synthase-subunit-A
MNEEAIVFALGPLAITRPVVTTWVVMAVLVAFCALVTRRLKLEPDRWQTVLEGVVDTIHRTVEETLPGHGLRLMPFIGSLWIFLAIANLVGILPGATSPTGDLSTTSALAILVFASVHWYGLTSEGPRAYLRHYLQPSPIMLPFHIVSEISRTVALAVRLFGNVMSLETAAVLVLLVAGFLVPVPVLALHIVEALVQAYIFGMLALVYISGGIQSQQRLSQDQDLTHGASS
>NZ_CP048836.1|WP_173766876.1|3251353_3251650_+|AtpZ/AtpI-family-protein
MNAAGPEQSQRDQLDDAVRQDCERLEAAERERRTVLGYTVFMGTIAGLFVVPVVAGAYLGRWLDGLAPGYSVRWTVSLILLGVFFGAVNVYRFIKEHR
>NZ_CP048836.1|WP_173766874.1|3250961_3251357_+|F0F1-ATP-synthase-subunit-epsilon
MTGFRLTLACPRRVEHIDAVASFVGTDASGRFGILAGRTPLITVLRFGLARFRVAGAADWRYLALPGGTLHFADNALAIACRHFTLGDDAAALQAALTEGARCEDERRADLRHNLDRFEQTLMQRLWELER
>NZ_CP048836.1|WP_173766872.1|3249576_3250965_+|F0F1-ATP-synthase-subunit-beta
MSAHQIASMHRIGTIEAVQGPVVDIVCERTPPLHQALWTQPDGEPCRLEVFRELGERHVRAIALHRTTGLARGLPVMDGGGPLQVPVGPECLGRMLDVFGAPLDGQPPFPATEHRPLVAPPGPLAQARAAERVLETGIKVIDLLCPFVRGGKTGLFGGAGVGKTVLITEFMNAVIQLHQGVSVFAGIGERIREGHELWHDMRAAGVMPRTVMVFGQMDESPGVRFRVGLTGLTYAEYLRDTTARDVLLLIDNVFRFVQAGSEISGLLGRMPATVGYQPTLLSEVAELQERIASSTAGSITSVQAVYVPADDMTDPAVSAIFSHLDTMVVLSRQQAAKGIYPAVDPLASTSKMMDRHFLGERHYRVAEAVREHLARYKELEDIIAMLGMEALSETDRQVVGRARRLQRYLTQPFHVVAQHTGIAGTSVPLETTLADCEGFIDGRFDALSEADCYMRGAMEPAP
>NZ_CP048836.1|WP_173766870.1|3246874_3249232_-|TonB-dependent-siderophore-receptor
MTRQTRKPCIPASFRVPATASAGAMARTGLALGVSTFALMPMAMAQSAEAPATLAPVQVVGEAIDPNPDAEPGAPYKARTSGDERHVKPIAETPQTITVLTGQQMQDTGRSDLRDILRAQPGITLGTGENGNAFGDRYIIRGQEARSDVFVDGLRDPGMTVRESFAVEQLEITKGPSSTFAGRGATGGAINAITKQATTDVGFNKLSAGIGTDDYRRLTADSNVVINDMSAVRINLLHAYQEVPDRGPADRERNGVALSYNLRPTDTLDLTADYYHLDSDDRPDLGSWLDDQRKPTKHIPVYAQEQDFLESEIDTYTLRARYYIDGDTRVTNLTRYGTTTNGYVATGARATTTDPTDPNGVYDTVSLSTHQGWQEVEYFANQTNLYLDRELGEQFHQFIFSLEYTDHSVLNGQYDVTNATNCITAGRSGPRASTCIVDPSGNTIDGINSVLNRQISKGDPDIDWNVKTISLAAMDTVDLTDEWTLFAGLRYDRFDYRNVVTDRNGVTTEWKLDDGLWNGHLGLTWQFRPDANVYLTYSTASDFNGGESDVSSCDYGGICVPSTGPSGTLSTAERQALFAQSKPELSENIELGTKWNVNRGKLLLTAAFFQVTKSDVMEIVGGASYTDIGAINTGKYRVRGVEFGLAGNLTERLSAQAGLAIMNAKWLKSQDDTRVGAGLTNFPETSASVLLSYAVTPVFTVGGNVTYQGRKYSGTPESPEQLSVKVPDYTVLDLFAAYRFNRNLSARLNIGNVTDETYYLSAYRSGAFMYLGDARSARLTFNYDF
>NZ_CP048836.1|WP_173766890.1|3265413_3266073_-|DsbA-family-oxidoreductase
MTLHIDLIADFICPWCHVGETRLRTALQQLAAKRPDVQVEIQRLPFFLDDTTPPEGYDYQSYLEKKFGSAEAVAEVQAQVSQAGEADGVHFAFDKISLRPSTLPAHRLMLQLQAVGADPVLTSKLAQYIFSAYFEAGKNIGDPKQLATIAQLAGVQDKDLADWLAGDDATDEVKAVFEQVKSLGIQGVPFFVFNQRLAVSGAQSPENLLSAMEQALDAE
>NZ_CP048836.1|WP_173766892.1|3266123_3267002_-|hypothetical-protein
MRAAFAFVCLVVMLLAPSGCSTVSLGYRNAPLIAAWWIDERFDLPGPQQDAVRAALDATWQWHVAHARAELVGLMDEAATRLGRPVGEADVEWVFAAMEGHARAVGRHFGDELAARWPRMTPAQLSALDAHLAERRAEWAQTRADESPEQRVQRRTEQIVDELTDWFGELTDAQQIYIARSEAVRLDDTLWQRERVRRQAQLLDILRHDPPEGLAAWIPDPPQDRPPAVAAEAVRQRAVYRRFWVGLLAMAQPAQIAHAQSRLREWADDLAAVAPMPTRVARRRDDATCQTC
>NZ_CP048836.1|WP_173768839.1|3267121_3267610_+|TIGR00645-family-protein
MEKLIERGMYASRWLLAPLYFGLSLTLLALVLKFFQEIFHVLPHVFDVAETDLVLTILSLIDMALVGGLLVMVMLSSYENFVSQLDIGDDTEKLGWLGKMDSSSLKNKVAASIVAISSIHLLKVFMNAKNIDAEHLKWYVILHLTFVASAFAMGMLDKLTKH
>NZ_CP048836.1|WP_173766893.1|3267609_3267837_+|oxidoreductase
MADPFTRRLASLDEAEAAIAEILATLGAAAEGFRAPPPAPTTCCGRGCNGCVWEGYYTALEFWREDARERLTAAE
>NZ_CP048836.1|WP_173766895.1|3267820_3269200_-|FAD-binding-oxidoreductase
MDALIDAIRHVVGETGLVRGEAVAARATSYWDPAPCRARAIVRPASTAEVAEVLRLCHAAGQAVVTQGGVTGCSQGADARAGELVLSTERLNAIEAIDPVGGTATVQAGVTLQALQEAARAHDRLFALDLGARGSCTVGGNVATNAGGINVLRYGMMRAQVLGLEAVLADGTIVSSMNHMLKNNSGFDLKQLMIGTEGTLGVVTRVVVRLHPLPASRNTALVALRDFDAVTELLTRMQRDMAGTLSAFEVMWNLYYRAATAPGGHRAPMADAHPFYVLMEAEGADTTADAARFEAVLAAVLDAGLIDDAVLPQSEAERRALWEIRENFEAMLVGRETFLYDVSLPIGEMAGYADEVLAAMDATWPQGRAIIFGHVADGNLHLFIQPQQAGATHAQSDALVYAPLTRRQGAVSAEHGIGQEKLGWLDRCRSAAEIALMRTLKQALDPKGILNPGRVIPPP
>NZ_CP048836.1|WP_173766897.1|3269359_3269848_+|hypothetical-protein
MPMPAPASEATTLLQQALAAIEADDHTSALRLLKAGADEHPDDAQITYWLGAEYACLELFDAAEAALERALAIDPAHHLARFHLGLLMVTRARFEAAVGVWQALDALPDGAPLRHYKQAFDALAQDRFAPARREIDAALAAGGATADLDAQMRRLRDSLPAA
>NZ_CP048836.1|WP_173766899.1|3269860_3270457_-|hypothetical-protein
MADMAFSRARFGRADIRLPDPVPAHPLLDGLPEIGRGEYSIVLALPDGARVRKVVSSPADHFFLTADDRPRGIHFPTVFADHGVIGRARSGALMHLLELERLEPLAAHAEAAAQAERLQTAYWQACLGFARLGADMGRIALFHLIESPPPLPDTLIAALCALSDFIEAYQVRPDILSEGNLMARADGTLVFSDPVFLG
>NZ_CP048836.1|WP_173766901.1|3270467_3271247_-|enoyl-ACP-reductase-FabI
MKPIIDLSGKVGLITGIANEKSISTGVAEACVEAGARLVVTYQNEKTRAFIEPVVHRLGLEHVCLMDVTRPETMDETFATIDRAFGKLDFAIHSMAFAKRDDLHGRVVDTSADGFALAMDVSTHSFVRMAKCAEPLMEKAGGGALITMTYLGSEKVIPHYGVMGLCKAALEAATRYMACELGQKNIRVNAVSPGPLMTRAASGIARFDDLMASAVERSPMHSLVTPEDIGALTAFLVSDAGRLVTGGVHFVDAGYNIIG
>NZ_CP048836.1|WP_173766903.1|3271413_3271938_+|hypothetical-protein
MSHPDTYVFLDFDGVTHPWRDVEDFRSLPLIEQVAREFDELRFVITSDWRTLYSLPRLRTRFAEDVRERVIGTTPLILPRAGGGLYGLREHEARSWLAKHARQSQRWFAIDDAPGNWPTRARLILTDFKQGFMDEDAARMRQMAQAMREGAWDEAQADERPGFWPRFAFGGGLA
>NZ_CP048836.1|WP_173766905.1|3271983_3273555_-|alkyl-hydroperoxide-reductase-subunit-F
MLDANLKQQLATYLQNLKLPIEITASVDGGEKSAEMLALLREIAELSTLISLTESRDDAERKPSFRINRVGADMGVRFAGIPMGHEFTSLVLALLQAGGHPPKVDEDTIAQIRALDGEFEFVTYISLSCQNCPEVVQALNLMAVLNPKVRHTMVDGALFQAEVEEKKILAVPTVHLNGREFGQGRMNLKEILAKVDTGAQARAAAKLAEQDPFDVLIVGGGPAGAAAAIYAARKGVRTGVLAERFGGQVMDTMAIENFISVQETEGPKLVAALEAHVKQYDVEVMDGFRAEALVPGEMNEIQVAGGAHLKAKSVIIATGARWREMNVPGEREYRGKGVAYCPHCDGPLFKGKRVAVIGGGNSGVEAAIDLAGIVAHVTLLEFGEQLRADAVLQAKLKSLPNVTIHTMAQTTEVTGADGKVNGLTYTDRNNGESHHVELEGVFVQIGLLPNTDWLKGTVELSRFGEIEINPRCETSVAGVFAAGDATTVPYKQIIIAMGEGSKAALSAFDHLIRASAPTEAVPA

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Crispr_ID: NZ_CP048836_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048836_5

4036856-4036959

Orphan

Consensus_repeat	Method
CAGCGAGCATCGCGAGCGTGGGGGCC	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP048836_5

>merge|NZ_CP048836|5|4036856-4036959|CRISPRCasFinder
CAGCGAGCATCGCGAGCGTGGGGGCCGACCGCGCCGACCGCCGGGCCGCCCCAAGGGCGGCGCAGCCCCCTCGGGGGGCAGCGAGCATCGCGAGCGTGGGGGCC

>NZ_CP048836|5|5|4036856-4036959|CRISPRCasFinder
CAGCGAGCATCGCGAGCGTGGGGGCC	GACCGCGCCGACCGCCGGGCCGCCCCAAGGGCGGCGCAGCCCCCTCGGGGGG
CAGCGAGCATCGCGAGCGTGGGGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048836.1\|WP_173768088.1\|4037878_4038202_-\|iron-sulfur-cluster-assembly-accessory-protein	unknown	unknown	gnl\|CDD\|272875
NZ_CP048836.1\|WP_173768100.1\|4041304_4041574_-\|ferredoxin-III,-nif-specific	unknown	unknown	gnl\|CDD\|274356
NZ_CP048836.1\|WP_173768066.1\|4026294_4028838_-\|nitrate-reductase-catalytic-subunit-NapA	unknown	unknown	gnl\|CDD\|237416
NZ_CP048836.1\|WP_173768084.1\|4035534_4036743_-\|cysteine-desulfurase-NifS	unknown	unknown	gnl\|CDD\|132443
NZ_CP048836.1\|WP_173768082.1\|4035038_4035473_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048836.1\|WP_173768094.1\|4039951_4040545_+\|glutathione-S-transferase	unknown	unknown	gnl\|CDD\|198315
NZ_CP048836.1\|WP_173768105.1\|4041806_4042268_-\|NifX-associated-nitrogen-fixation-protein	unknown	unknown	gnl\|CDD\|131981
NZ_CP048836.1\|WP_173768096.1\|4040546_4040957_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048836.1\|WP_173768078.1\|4033719_4033935_-\|DNA-directed-RNA-polymerase-subunit-omega	unknown	unknown	gnl\|CDD\|234744
NZ_CP048836.1\|WP_173768068.1\|4028839_4029100_-\|chaperone-NapD	unknown	unknown	gnl\|CDD\|367731
NZ_CP048836.1\|WP_173768074.1\|4031213_4031402_-\|DUF3460-family-protein	unknown	unknown	gnl\|CDD\|378768
NZ_CP048836.1\|WP_173768072.1\|4029743_4031153_-\|ethanolamine-utilization-protein	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|236123
NZ_CP048836.1\|WP_173768076.1\|4031471_4033682_-\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|223394
NZ_CP048836.1\|WP_173768070.1\|4029096_4029600_-\|ferredoxin-type-protein-NapF	unknown	unknown	gnl\|CDD\|319886
NZ_CP048836.1\|WP_173768102.1\|4041570_4041795_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377451
NZ_CP048836.1\|WP_173768080.1\|4033941_4034556_-\|guanylate-kinase	unknown	unknown	gnl\|CDD\|234719
NZ_CP048836.1\|WP_173768092.1\|4039412_4039955_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|274926
NZ_CP048836.1\|WP_173768090.1\|4038394_4039306_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176160
NZ_CP048836.1\|WP_173768098.1\|4040960_4041305_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048836.1\|WP_173768086.1\|4036972_4037866_-\|Fe-S-cluster-assembly-protein-NifU	unknown	unknown	gnl\|CDD\|273921

Protein	Function_ID	Function_description	E-value
NZ_CP048836.1\|WP_173768088.1\|4037878_4038202_-\|iron-sulfur-cluster-assembly-accessory-protein	gnl\|CDD\|272875	TIGR00049, Uncharacterized_protein_in_nifU_5'region, Iron-sulfur cluster assembly accessory protein. Proteins in this subfamily appear to be associated with the process of FeS-cluster assembly. The HesB proteins are associated with the nif gene cluster and the Rhizobium gene IscN has been shown to be required for nitrogen fixation. Nitrogenase includes multiple FeS clusters and many genes for their assembly. The E. coli SufA protein is associated with SufS, a NifS homolog and SufD which are involved in the FeS cluster assembly of the FhnF protein. The Azotobacter protein IscA (homologs of which are also found in E.coli) is associated which IscS, another NifS homolog and IscU, a nifU homolog as well as other factors consistent with a role in FeS cluster chemistry. A homolog from Geobacter contains a selenocysteine in place of an otherwise invariant cysteine, further suggesting a role in redox chemistry. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	5.92926e-45
NZ_CP048836.1\|WP_173768100.1\|4041304_4041574_-\|ferredoxin-III,-nif-specific	gnl\|CDD\|274356	TIGR02936, fdxN_nitrog, ferredoxin III, nif-specific. Members of this family are homodimeric ferredoxins from nitrogen fixation regions of many nitrogen-fixing bacteria. As characterized in Rhodobacter capsulatus, these proteins are homodimeric, with two 4Fe-4S clusters bound per monomer. Although nif-specific, this protein family is not usiveral, as other nitrogenase systems may substitute flavodoxins, or different types of ferredoxin. [Central intermediary metabolism, Nitrogen fixation].	2.50536e-39
NZ_CP048836.1\|WP_173768066.1\|4026294_4028838_-\|nitrate-reductase-catalytic-subunit-NapA	gnl\|CDD\|237416	PRK13532, PRK13532, nitrate reductase catalytic subunit NapA.	0
NZ_CP048836.1\|WP_173768084.1\|4035534_4036743_-\|cysteine-desulfurase-NifS	gnl\|CDD\|132443	TIGR03402, Cysteine_desulfurase_NifS, cysteine desulfurase NifS. Members of this protein family are NifS, one of several related families of cysteine desulfurase involved in iron-sulfur (FeS) cluster biosynthesis. NifS is part of the NIF system, usually associated with other nif genes involved in nitrogenase expression and nitrogen fixation. The protein family is given a fairly broad interpretation here. It includes a clade nearly always found in extended nitrogen fixation genomic regions, plus a second clade more closely related to the first than to IscS and also part of NifS-like/NifU-like systems. This model does not extend to a more distantly clade found in the epsilon proteobacteria such as Helicobacter pylori, also named NifS in the literature, built instead in TIGR03403.	0
NZ_CP048836.1\|WP_173768094.1\|4039951_4040545_+\|glutathione-S-transferase	gnl\|CDD\|198315	cd03206, GST_C_7, C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases. Glutathione S-transferase (GST) C-terminal domain family, unknown subfamily 7; composed of uncharacterized proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. GSTs also show GSH peroxidase activity and are involved in the synthesis of prostaglandins and leukotrienes. The GST fold contains an N-terminal thioredoxin-fold domain and a C-terminal alpha helical domain, with an active site located in a cleft between the two domains. GSH binds to the N-terminal domain while the hydrophobic substrate occupies a pocket in the C-terminal domain.	1.83919e-52
NZ_CP048836.1\|WP_173768105.1\|4041806_4042268_-\|NifX-associated-nitrogen-fixation-protein	gnl\|CDD\|131981	TIGR02935, UPF0460_protein_in_nifX_3'region, probable nitrogen fixation protein. Members of this protein family, called DUF269 by pfam03270, are strictly limited to nitrogen-fixing species, although not universal among them. The gene typically is found next to the nifX gene (see TIGRFAMs model TIGR02663). [Central intermediary metabolism, Nitrogen fixation].	2.47532e-72
NZ_CP048836.1\|WP_173768078.1\|4033719_4033935_-\|DNA-directed-RNA-polymerase-subunit-omega	gnl\|CDD\|234744	PRK00392, rpoZ, DNA-directed RNA polymerase subunit omega; Reviewed.	6.13266e-26
NZ_CP048836.1\|WP_173768068.1\|4028839_4029100_-\|chaperone-NapD	gnl\|CDD\|367731	pfam03927, NapD, NapD protein. Uncharacterized protein involved in formation of periplasmic nitrate reductase.	3.90738e-18
NZ_CP048836.1\|WP_173768074.1\|4031213_4031402_-\|DUF3460-family-protein	gnl\|CDD\|378768	pfam11943, DUF3460, Protein of unknown function (DUF3460). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are about 70 amino acids in length. This protein has a conserved WDK sequence motif.	2.54477e-22
NZ_CP048836.1\|WP_173768072.1\|4029743_4031153_-\|ethanolamine-utilization-protein	gnl\|CDD\|236123	PRK07883, PRK07883, DEDD exonuclease domain-containing protein.	9.33391e-75
NZ_CP048836.1\|WP_173768076.1\|4031471_4033682_-\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	gnl\|CDD\|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	0
NZ_CP048836.1\|WP_173768070.1\|4029096_4029600_-\|ferredoxin-type-protein-NapF	gnl\|CDD\|319886	cd10564, NapF_like, NapF, iron-sulfur subunit of periplasmic nitrate reductase. This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.	1.41342e-59
NZ_CP048836.1\|WP_173768102.1\|4041570_4041795_-\|hypothetical-protein	gnl\|CDD\|377451	pfam05082, Rop-like, Rop-like. This family contains several uncharacterized bacterial proteins. These proteins are found in nitrogen fixation operons so are likely to play some role in this process. They consist of two alpha helices which are joined by a four residue linker. The helices form an antiparallel bundle and cross towards their termini. They are likely to form a rod-like dimer. They have structural similarity to the regulatory protein Rop, pfam01815.	9.74304e-18
NZ_CP048836.1\|WP_173768080.1\|4033941_4034556_-\|guanylate-kinase	gnl\|CDD\|234719	PRK00300, gmk, guanylate kinase; Provisional.	1.24447e-118
NZ_CP048836.1\|WP_173768092.1\|4039412_4039955_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|274926	TIGR04025, hypothetical_protein, PPOX class probable FMN-dependent enzyme, DR_2398 family. Members of the PPOX family (see pfam01243) may contain either FMN or F420 as cofactor. This subfamily consists of proteins mostly from species that lack the capability to synthesize F420, and therefore most likely all bind FMN.	6.90273e-12
NZ_CP048836.1\|WP_173768090.1\|4038394_4039306_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176160	cd08471, PBP2_CrgA_like_2, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 2. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.68371e-92
NZ_CP048836.1\|WP_173768086.1\|4036972_4037866_-\|Fe-S-cluster-assembly-protein-NifU	gnl\|CDD\|273921	TIGR02000, Nitrogen_fixation_protein_NifU, Fe-S cluster assembly protein NifU. Three different but partially homologous Fe-S cluster assembly systems have been described: Isc, Suf, and Nif. The latter is associated with donation of an Fe-S cluster to nitrogenase in a number of nitrogen-fixing species. NifU, described here, consists of an N-terminal domain (pfam01592) and a C-terminal domain (pfam01106). Homologs with an equivalent domain archictecture from Helicobacter and Campylobacter, however, are excluded from this model by a high trusted cutoff. The model, therefore, is specific for NifU involved in nitrogenase maturation. The related model TIGR01999 homologous to the N-terminus of this model describes IscU from the Isc system as in E. coli, Saccharomyces cerevisiae, and Homo sapiens. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other, Central intermediary metabolism, Nitrogen fixation].	6.17291e-156

>NZ_CP048836.1|WP_173768084.1|4035534_4036743_-|cysteine-desulfurase-NifS
MKPIYLDNNATTRVDPAVVEAMLPFFTEHFGNASSMHAFGSQVGRALKTARGQVQALIGAEHDSEIIFTSCGTESDATAILSALKAQPERNTVIITAVEHPAILSLGEWLEKEGVVVHKLGVDKKGRIDIDEYKSMLHDRVAVVSAMWANNETGTLFPVEQMAEIAHAKGIMFHTDAVQAVGKIPIDLKNTKIDMLSLSGHKLHAPKGIGVLYLRRGCRFRPLLRGGHQERGRRAGTENAAGIVALGKACELAQAHLEVENTQVRALRDRLEQGILGQISHCFATGDTSNRLPNTSNIAFEYIEGEAILLLLNKLGIAASSGSACTSGSLEPSHVMRAMGIPYTAAHGTIRFSLSRENTAEEVDRVIASVPPIIDQLRKLSPYWNGDAPAASPEAAFAPTYA
>NZ_CP048836.1|WP_173768082.1|4035038_4035473_+|hypothetical-protein
MSSKSDKNVRKILGTAAVALAVPAAASAAAAINTSMIDNASMSSPAGKRQARLREDGGEPELFPLKLRPSLTAAKEVGEKPIQVKVMDSEGRRILLARAHGNITLGPLPAGEYRLQLRSGANTEEHAMKLGSGKRGLLRYELGA
>NZ_CP048836.1|WP_173768080.1|4033941_4034556_-|guanylate-kinase
MPGTLIIVTAPSGAGKTTLVQGLLKADTGVQLSVSYTTRAPRPGEADGREYRFVDINRFRELRDAGEFLEWAEVHGNYYGTSKAWLRSELDAGRDTLVEIDWQGAQQVRKMFPESVGIFILPPSMDELERRLRGRGTDSEEVIIRRLLGARGEMRHVSEFDYVIINNELPDALEDLVAVVRAARLRYANQHARHPSYFDFLEKD
>NZ_CP048836.1|WP_173768078.1|4033719_4033935_-|DNA-directed-RNA-polymerase-subunit-omega
MARITVEDCLKRIPNRFQLTLAATYRARQLTVGNEPQVELDKSDKDKPTVIALREIAAGKVGLEVLNRGQA
>NZ_CP048836.1|WP_173768076.1|4031471_4033682_-|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase
MRSPSVDIGRPIPAPFAPPASSVPTLDFERLRKKIATYLRPEDVGRIENAYYFSRNAHQGQYRTSGEPYITHPVAVTELVAEWHLDSQALMAALLHDVMEDTSVTKEELTERFGKQTAELVDGLSKLDKIEFRSQEEAQAENFRKMLLAMASDLRVILIKLADRLHNMRTLDYVRPAKRRRIATETLEIYAPIANRLGLNQLYRELQELSFMHKHPMRYQVLSKAVKAARGNRRELVGKVLTALEGRLPQWGISAEIQGREKHIYGIYRKMVEKHLTFSQVLDIYGFRVIVPDVPSCYLTVGALHALYKPVPGKFKDYIAIPKANGYQSLHTTLIGPYGTPVEVQVRTRQMHHVAESGVASHWLYKDDESSLSELAQKTHSWLQSLIELQSASAEATEFLEHVKIDLFPSEVYVFTPQGHILSLQRGSTPVDFAYAVHTDIGNRCVACRVNGELVPLRSELRNGDQVEIITAAHAGPNPAWLSYVRTGKARAQIRHFLKTAQQDEAVTLGERLLNQALRPHGLTLGQISTFAWDRFLRDRGVRARREVFADLGLGKRLPVIVARRLAEAQDMESGRPDVIKPKPAGAVLIRGSEGAAVQLARCCHPIPGDEIIAAVRKGQGLEVHVHDCPAVSRLRGDRGRWIDVGWEPVDDRLFEVAIRVVTIDNRGVLAKVASAISEAEANILNVTMDSEQAPYTVLTFNIEVADRKHLARVIRHVRVQPAVTRVSRQKAEIKR
>NZ_CP048836.1|WP_173768074.1|4031213_4031402_-|DUF3460-family-protein
MALYESEHTKFMREWMEKHPEQKGEQQQGRALWWDKPQDAETRTRQNAAKVPPKPYYYQTDN
>NZ_CP048836.1|WP_173768072.1|4029743_4031153_-|ethanolamine-utilization-protein
MTLPQRLAIVDLETTGAHPVRDRITEIAILRVEDGRVVERWSSLTNPGVHIPATIQNFTGITDAMVADAPPFETLADAVWALLDDAVFVAHNARFDYGFLKNAFERLGRSFDAPVLCTVKLSRALYPAHHRHGLDAIIERHGLTCEARHRAMGDADVLWQFLQQAVDAFPAPNLGNAIDRAMKRPSRPPGLPEGVLEGMPDSPGVYFFYGDNDLPLYIGKSKRIRARVMSHFAADRMNGKEAELARQVRRVEWEQTAGELGALLLEACLIKHHRPLHNRLLRKNDDVFGLRVVPSNKRKAQVLERVPLSDTDPRDWADVFGAFRTKKEADNLLRELAHLYKLCPRRLGLEPGRTGACMAHQMKRCAGVCAGKETPEAHDARLMAALSGKGVKPWPWQGPVCVAEHDDSTGRSEFHLLDRWCYLATARSDADVLDSLQGATYAFDIDIYRLLVRWFDAISHRQAATPISP
>NZ_CP048836.1|WP_173768070.1|4029096_4029600_-|ferredoxin-type-protein-NapF
MDAARRGFLRGRLSRSAHVPRPPWAVAPGQFEQLCTRCGDCVTQCPTRIIRSGEGGYPTLDFSAGECTFCGDCVAACAPHALHRADGVAPWALKAVIGDRCLTGQGVECRICAENCDAGAIRCRPALGGIARPELQSDRCTGCGACVAPCPVGAIGVAQSNPMEIEQ
>NZ_CP048836.1|WP_173768068.1|4028839_4029100_-|chaperone-NapD
MNIASLVVRVAPGQREALTRELLEIPGVEVHGAAPDGGRLIVTVEDGEGYSMMDSILAVNVNKRVHGVTLAYEYTGDGIEMQEQEA
>NZ_CP048836.1|WP_173768066.1|4026294_4028838_-|nitrate-reductase-catalytic-subunit-NapA
MTMDRREFIKANAVAAAAATAGVALPTVANAADVTATDVRWDKAACRFCGTGCSVLVGVQDGRVVATQGDPDAPVNRGLNCIKGYFLSKIMYGKDRLTKPLLRMKDGKYAKDGEFTPVSWDQAFDIMAEKWKAALAHDIKANEGKAANELTSTVGMFGSGQWTVWEGYAASKLMKGGFRSNNIDPNARHCMASAVAGFIRTFGIDEPMGCYDDLENADAFVLWGSNMAEMHPILWSRLTDRRLTHKGCEVHVLSTFEHRSFELADNGMIFTPQTDLAILNYIANYIIQNKAVNTEFVTKHTKFAMGNTDIGYGLRPTDPREKAAKNATKAGGSKPISFDEYAAFVSEYTLEKVAKLSGVPAERLERLAKLYADPNKKVVSYWTMGFNQHTRGTWANNLCYNIHLLTGKISKPGCGPFSLTGQPSACGTAREVGTFAHRLPADFVVAKPEHRKVGEKIWKLPEGFLNGKVGYHAVLQSRMLKDGKLKVYWVTCNNNMQAGPNTNDETYPGWRNPEAFVVVSDPYPTVSALSADLILPTAMWTEKEGAYGNAERRTQFWRQQVAPPGEAKSDLWQFVEFSKRFKVEEAWPADMVAKMPEYKGKTLFDVLFKNGQVDAFPISDVAKANDHAWTGYMNDESKELGFYLQKGLFEEYASWGRGHGHDLADFDAYHKARGLRWPVVDGKETLWRFREGYDPYVTKGADIEFYGKPDKRAVIFALPYEPPAESPDQEYDLWLCTGRVLEHWHTGSMTQRVPELHRSVPEAQIFMNPDDAARRGLQRGMEVKVTSRRGEIVARIETRGRNKPPQGLIFIPFFDEGRLVNKLTLDATCPISKETDFKKCAVKVTKA
>NZ_CP048836.1|WP_173768086.1|4036972_4037866_-|Fe-S-cluster-assembly-protein-NifU
MWEYSDKVREHFFNPRNSGPLDAANGIGDVGSIQCGDALRLMLQVDPETEVIQDAHFQTFGCGSAIASSSALTEIIKGMTLDEALKVSNQDIADYLDGLPPEKMHCSVMGREALQAAVANYRGEVWEDDHEEGALVCKCFAIDAVMIEDTIRANNLKTVQDVTHYTKAGGGCAACHEGIEDILARVMAESASGAEVSPPTEAEAGVAAAAPAKKLTLVQKIRKIEEVLEEVRPMLQRDHGDVELADVQGKMIYVHLKGACSGCMMEAATLGGIQQKMIEALGELVQVLPSSHMPVEA
>NZ_CP048836.1|WP_173768088.1|4037878_4038202_-|iron-sulfur-cluster-assembly-accessory-protein
MINLTPAAIKAVERFIRGSETPVAGLRLVVSGGGCSGLQYGMKLEAEKAEDDWELDVEGIKVLVDPMTMPMVDNVTIDFIDTLTHTGFKFENPNAAGSCACGQSFSV
>NZ_CP048836.1|WP_173768090.1|4038394_4039306_-|LysR-family-transcriptional-regulator
MDKLKAMDVFVHIVEAGSLTGAASRLGTSLASVVRQLAALEAVLGVRLINRTTRRMALTDEGREYVERCRRLLGELEDAERALTDRVHAPTGRIVMTAPVLFGRLHVAPVLSDFLLAHPQMRAELILLDRVVDLVEEGFDLALRIGPLPDSSLVGIAVGETARTLCASPAYLARHGRPAHPQALAADAGTHQMVGFTGFGAVGEWTFVRDGERHRVRVCERFVTNQVPAALDACAKGLGIGRFLGYQVADAIAAGTLEPVLADWAPAPEPVHLLMPSARLTSPRVRAFVDWAVPRLRSVLAGA
>NZ_CP048836.1|WP_173768092.1|4039412_4039955_+|pyridoxamine-5'-phosphate-oxidase-family-protein
MNPHFARLAFTPQVRDTQQALNGQPLSPPADPLPPLALGERERRFIAARDSFYLATVGATGWPHVQHRGGHTGFLRILDEHTLAFADYPGNRQYVSVGNLGDEPRAALIMVDYNARRRLKLLAQIRVVPREAADFDLLDALAVPPDQPFERVMVLDVKAFDWNCSQYISPRTGPTPEETP
>NZ_CP048836.1|WP_173768094.1|4039951_4040545_+|glutathione-S-transferase
MKLHDLELSGNCYKVRLFAALTNIPIEVVPVDFLGGEHKRAPLITLNPWGQLPVLEDGEVVLRDSQAILVYLAGKYGKTDWWPTEPTDQARVAQWLSTAANEIQNGPGAARLVDKFGIALDKAEAVRRAEHILALIEGHLAHHDWLALDRPTIADCAVMPYVALAPEGGVALAPYPRIRAWIGRIKALPGFRPMPGV
>NZ_CP048836.1|WP_173768096.1|4040546_4040957_-|hypothetical-protein
MGARLILLHKQKTSAMVRFLCLPGGLLAFPPMPAGARLREADWAPAVAVHPAPHLAAAAERLGLPAEAIEAEGGFRAWLDTSEGDVPVLMGVFTAIDPPVEAVARAGGRFIPMMEARALSHLDQQLIRRAYEHVLG
>NZ_CP048836.1|WP_173768098.1|4040960_4041305_-|hypothetical-protein
MGIAADRDVGEAVCAALRAQVRRVGLSIGDEPVWQAATVDMTRDPYSQESSLVATWRGGARFGTATFFPDGRVFAEYQVLLPHPRRDGQFVEAVQVWGMPDALCGDAVLVALPE
>NZ_CP048836.1|WP_173768100.1|4041304_4041574_-|ferredoxin-III,-nif-specific
MITGTTRGGEEWTPHFVEALDQEKCIGCGRCYKVCPRTVLDLVERELDDDDDDEDDNMMVMSIANGLDCIGCGACGRVCPKNCYTYAAA
>NZ_CP048836.1|WP_173768102.1|4041570_4041795_-|hypothetical-protein
MTDEELKGLEKAVRKLKRIAAERASELHDLVEDRLPAAYDDIPLIAQSTYDACKAWADANTRLQAVLSETTSRS
>NZ_CP048836.1|WP_173768105.1|4041806_4042268_-|NifX-associated-nitrogen-fixation-protein
MTDAVAADPILETDFIKEMTRQMRALDTYGTYAGYSVEQLLDPFVLTREKKAEIPIVGDPDELTLARVKCFYNAIAVLIEKECGQLAVPLIHLTHEGFGRALITVGYLVAIDKTLRDVHRFGFASLSKMKDEADKLLSVAIERIGKHPDVAGM

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP048836_2	2.1\|1230347\|45\|NZ_CP048836\|CRISPRCasFinder	1230347-1230391	45	NZ_CP048836.1	1230034-1230078	0	1.0
NZ_CP048836_2	2.1\|1230347\|45\|NZ_CP048836\|CRISPRCasFinder	1230347-1230391	45	NZ_CP048836.1	1230190-1230234	1	0.978
NZ_CP048836_4	4.1\|3263180\|19\|NZ_CP048836\|CRISPRCasFinder	3263180-3263198	19	NZ_CP048836.1	2682391-2682409	2	0.895
NZ_CP048836_4	4.3\|3263264\|19\|NZ_CP048836\|CRISPRCasFinder	3263264-3263282	19	NZ_CP048836.1	497528-497546	2	0.895
NZ_CP048836_4	4.3\|3263264\|19\|NZ_CP048836\|CRISPRCasFinder	3263264-3263282	19	NZ_CP048836.1	1235578-1235596	2	0.895
NZ_CP048836_4	4.3\|3263264\|19\|NZ_CP048836\|CRISPRCasFinder	3263264-3263282	19	NZ_CP048836.1	1713545-1713563	2	0.895

1. spacer 2.1|1230347|45|NZ_CP048836|CRISPRCasFinder matches to position: 1230034-1230078, mismatch: 0, identity: 1.0

gagcgcaccgcccgccgggccgccccaagggcggtgcagccccct	CRISPR spacer
gagcgcaccgcccgccgggccgccccaagggcggtgcagccccct	Protospacer
*********************************************

2. spacer 2.1|1230347|45|NZ_CP048836|CRISPRCasFinder matches to position: 1230190-1230234, mismatch: 1, identity: 0.978

gagcgcaccgcccgccgggccgccccaagggcggtgcagccccct	CRISPR spacer
gagcgcaccgcccgccgggccgccccaagggcggagcagccccct	Protospacer
********************************** **********

3. spacer 4.1|3263180|19|NZ_CP048836|CRISPRCasFinder matches to position: 2682391-2682409, mismatch: 2, identity: 0.895

gcagttcctcgttggaggc	CRISPR spacer
gcaggtcctcgttggtggc	Protospacer
**** ********** ***

4. spacer 4.3|3263264|19|NZ_CP048836|CRISPRCasFinder matches to position: 497528-497546, mismatch: 2, identity: 0.895

cgaacttgtcgatcaccgc	CRISPR spacer
cgaagttgtcgaacaccgc	Protospacer
**** ******* ******

5. spacer 4.3|3263264|19|NZ_CP048836|CRISPRCasFinder matches to position: 1235578-1235596, mismatch: 2, identity: 0.895

cgaacttgtcgatcaccgc	CRISPR spacer
cgaacttggcgatcgccgc	Protospacer
******** *****.****

6. spacer 4.3|3263264|19|NZ_CP048836|CRISPRCasFinder matches to position: 1713545-1713563, mismatch: 2, identity: 0.895

cgaacttgtcgatcaccgc	CRISPR spacer
cgagcttgtcgatcaacgc	Protospacer
***.*********** ***

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP048836_3	3.1\|1324667\|40\|NZ_CP048836\|CRISPRCasFinder	1324667-1324706	40	NZ_CP044073	Pseudomonas oryzihabitans strain FDAARGOS_657 plasmid unnamed2, complete sequence	183374-183413	10	0.75

1. spacer 3.1|1324667|40|NZ_CP048836|CRISPRCasFinder matches to NZ_CP044073 (Pseudomonas oryzihabitans strain FDAARGOS_657 plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.75

ctcggccgc---ggcgtcgccgccaccctcggtgtcggcctgt	CRISPR spacer
---ggccatgcaggcgtcgccggcacccacggtgtcggccacg	Protospacer
   ****..   ********** ***** ***********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

211954 : 221805

uncultured_Mediterranean_phage(14.29%)

protease

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_173763472.1\|211954_213409_-\|protease	DegQ family serine endoprotease	A0A1B1IT49	uncultured_Mediterranean_phage	2.6e-23	30.2
WP_173763473.1\|213630_214569_+	hydrogen peroxide-inducible genes activator	NA	NA	NA	NA
WP_173763474.1\|214670_215141_+	DNA starvation/stationary phase protection protein	W5S6G8	Pithovirus	3.0e-13	38.6
WP_173763475.1\|215261_215855_-	DUF924 domain-containing protein	A0A1V0SIY0	Klosneuvirus	1.2e-19	33.0
WP_173763476.1\|215851_218332_-	DNA topoisomerase III	A0A2P1ELA0	Moumouvirus	7.3e-18	22.4
WP_173763477.1\|218523_218991_-	DUF494 domain-containing protein	NA	NA	NA	NA
WP_173763478.1\|219004_220096_-	DNA-protecting protein DprA	S6BFL3	Thermus_phage	2.0e-28	35.4
WP_173763479.1\|220103_221129_-	LysM peptidoglycan-binding domain-containing protein	G3MBQ1	Bacillus_virus	9.4e-12	41.2
WP_173763480.1\|221301_221805_+	peptide deformylase	E3SLL2	Synechococcus_phage	9.0e-16	41.3

DBSCAN-SWA_2

1731379 : 1782404

Phage_DP-2017a(25.0%)

protease,tail,plate,transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_173764747.1\|1731379_1732348_+\|transposase	IS110 family transposase	A0A1S7J231	Thermus_phage	4.0e-20	30.7
WP_173764748.1\|1732439_1732955_-	ankyrin repeat domain-containing protein	NA	NA	NA	NA
WP_173764749.1\|1732959_1733427_-	hypothetical protein	NA	NA	NA	NA
WP_173764750.1\|1733597_1736486_-	aminomethyl-transferring glycine dehydrogenase	E3SN07	Prochlorococcus_phage	2.6e-269	52.4
WP_173764751.1\|1736840_1737224_-	glycine cleavage system protein GcvH	NA	NA	NA	NA
WP_173764752.1\|1737267_1738350_-	glycine cleavage system aminomethyltransferase GcvT	NA	NA	NA	NA
WP_173764753.1\|1738664_1739558_+	alpha/beta hydrolase	A0A249XU20	Mycobacterium_phage	2.5e-08	33.0
WP_173764754.1\|1739547_1740396_+	PHP domain-containing protein	NA	NA	NA	NA
WP_173764755.1\|1740411_1741038_+	threonylcarbamoyl-AMP synthase	NA	NA	NA	NA
WP_173764756.1\|1741087_1741747_+\|protease	site-2 protease family protein	NA	NA	NA	NA
WP_173764757.1\|1741755_1742958_+\|tRNA	tryptophan--tRNA ligase	NA	NA	NA	NA
WP_173764758.1\|1743000_1743834_+	segregation/condensation protein A	NA	NA	NA	NA
WP_173764759.1\|1743811_1744417_+	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	8.5e-21	40.2
WP_173764760.1\|1744442_1745585_+	pseudouridine synthase	NA	NA	NA	NA
WP_173764761.1\|1745715_1746150_+	ribosome maturation factor RimP	NA	NA	NA	NA
WP_173764762.1\|1746174_1747647_+	transcription termination/antitermination protein NusA	NA	NA	NA	NA
WP_173764763.1\|1747661_1750436_+	translation initiation factor IF-2	E3T4N3	Cafeteria_roenbergensis_virus	2.6e-24	32.5
WP_173764764.1\|1750448_1750835_+	30S ribosome-binding factor RbfA	NA	NA	NA	NA
WP_173768684.1\|1750863_1751796_+\|tRNA	tRNA pseudouridine(55) synthase TruB	NA	NA	NA	NA
WP_173764765.1\|1751900_1752170_+	30S ribosomal protein S15	NA	NA	NA	NA
WP_173764766.1\|1752344_1754447_+	polyribonucleotide nucleotidyltransferase	NA	NA	NA	NA
WP_173764767.1\|1754535_1754961_-	RNA polymerase-binding protein DksA	NA	NA	NA	NA
WP_173764768.1\|1755452_1756046_-	2-hydroxychromene-2-carboxylate isomerase	NA	NA	NA	NA
WP_173764769.1\|1756120_1756627_-	hypothetical protein	NA	NA	NA	NA
WP_173764770.1\|1756637_1759805_-	right-handed parallel beta-helix repeat-containing protein	NA	NA	NA	NA
WP_173764771.1\|1759821_1761918_-	hypothetical protein	NA	NA	NA	NA
WP_173768686.1\|1761914_1764071_-\|plate	putative baseplate assembly protein	NA	NA	NA	NA
WP_173764772.1\|1765741_1768351_-\|plate	putative baseplate assembly protein	A0A1Q1PVP2	Phage_DP-2017a	5.7e-05	31.7
WP_173764773.1\|1768347_1768716_-	GPW/gp25 family protein	NA	NA	NA	NA
WP_173764774.1\|1768718_1769039_-	hypothetical protein	NA	NA	NA	NA
WP_173764775.1\|1769298_1769811_-\|plate	baseplate assembly protein	A0A1Q1PVP0	Phage_DP-2017a	4.5e-07	27.6
WP_173764776.1\|1769807_1770947_-	hypothetical protein	NA	NA	NA	NA
WP_173764777.1\|1770939_1771302_-	LysM domain-containing protein	NA	NA	NA	NA
WP_173764778.1\|1771375_1772032_-	hypothetical protein	NA	NA	NA	NA
WP_173764779.1\|1772040_1773558_-	DUF4157 domain-containing protein	NA	NA	NA	NA
WP_173764780.1\|1773554_1774259_-	hypothetical protein	NA	NA	NA	NA
WP_173768688.1\|1774192_1775017_-	DUF4157 domain-containing protein	NA	NA	NA	NA
WP_173764781.1\|1775162_1776953_-	DUF4157 domain-containing protein	NA	NA	NA	NA
WP_173764782.1\|1776949_1777195_-	hypothetical protein	NA	NA	NA	NA
WP_173764783.1\|1777191_1779096_-	ATP-binding protein	K9MCS8	Sulfolobus_virus	1.1e-08	31.2
WP_173764784.1\|1779092_1780409_-	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_173764785.1\|1780405_1781176_-	hypothetical protein	NA	NA	NA	NA
WP_173764786.1\|1781172_1781874_-	hypothetical protein	NA	NA	NA	NA
WP_173764787.1\|1781879_1782404_-\|tail	phage tail protein	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP048836

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection