CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP049918	Bordetella bronchiseptica strain KVNON-570 chromosome, complete genome	8 crisprs	DinG,DEDDh,csa3,cas3	0	0	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP049918_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049918_1

206656-206764

Orphan

Consensus_repeat	Method
CGCTGCGCCAGCTTGCTGCCCCCCAGGGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049918_1

>merge|NZ_CP049918|1|206656-206764|CRISPRCasFinder
CGCTGCGCCAGCTTGCTGCCCCCCAGGGGGCGTTTGCCTTGGGGCGGCCCGGCGGTGGAAAATGCCCCCACGCTGCGCTCGCTGCGCCAGCTTGCTGCCCCCCAGGGGG

>NZ_CP049918|1|1|206656-206764|CRISPRCasFinder
CGCTGCGCCAGCTTGCTGCCCCCCAGGGGG	CGTTTGCCTTGGGGCGGCCCGGCGGTGGAAAATGCCCCCACGCTGCGCT
CGCTGCGCCAGCTTGCTGCCCCCCAGGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049918.1\|WP_003814185.1\|208365_208749_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NZ_CP049918.1\|WP_033447293.1\|201012_202536_+\|M48-family-metalloprotease	unknown	unknown	gnl\|CDD\|227122
NZ_CP049918.1\|WP_003814188.1\|206308_206638_+\|AzlD-domain-containing-protein	unknown	unknown	gnl\|CDD\|226827
NZ_CP049918.1\|WP_010931455.1\|205556_206306_+\|AzlC-family-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224215
NZ_CP049918.1\|WP_033447311.1\|214727_215453_-\|arginyltransferase	unknown	unknown	gnl\|CDD\|234939
NZ_CP049918.1\|WP_003814170.1\|213637_214687_-\|quinone-dependent-dihydroorotate-dehydrogenase	unknown	unknown	gnl\|CDD\|235388
NZ_CP049918.1\|WP_003814174.1\|211547_212525_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein-BugD	unknown	unknown	gnl\|CDD\|270294
NZ_CP049918.1\|WP_003814195.1\|204194_204407_-\|zinc-finger-domain-containing-protein	unknown	unknown	gnl\|CDD\|226826
NZ_CP049918.1\|WP_003814183.1\|208810_209611_+\|EI24-domain-containing-protein	unknown	unknown	gnl\|CDD\|377798
NZ_CP049918.1\|WP_003814193.1\|204453_205374_-\|branched-chain-amino-acid-transaminase	unknown	unknown	gnl\|CDD\|235841
NZ_CP049918.1\|WP_033446149.1\|199203_200076_+\|cytochrome-c-oxidase-assembly-protein	unknown	unknown	gnl\|CDD\|378238
NZ_CP049918.1\|WP_003814172.1\|212911_213490_+\|TIGR01841-family-phasin	unknown	unknown	gnl\|CDD\|130900
NZ_CP049918.1\|WP_003814179.1\|209664_210477_+\|competence/damage-inducible-protein-A	unknown	unknown	gnl\|CDD\|223986
NZ_CP049918.1\|WP_003814197.1\|203749_204172_-\|SnoaL-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379209
NZ_CP049918.1\|WP_165645713.1\|210635_211484_+\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_CP049918.1\|WP_003814206.1\|198018_199113_+\|porin	unknown	unknown	gnl\|CDD\|238208
NZ_CP049918.1\|WP_003814199.1\|202632_203733_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|223506
NZ_CP049918.1\|WP_003814203.1\|200097_200937_-\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	unknown	unknown	gnl\|CDD\|224131
NZ_CP049918.1\|WP_161782648.1\|206995_208354_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|236722
NZ_CP049918.1\|WP_003814164.1\|215489_216254_-\|leucyl/phenylalanyl-tRNA--protein-transferase	unknown	unknown	gnl\|CDD\|234720

Protein	Function_ID	Function_description	E-value
NZ_CP049918.1\|WP_003814185.1\|208365_208749_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	1.97539e-15
NZ_CP049918.1\|WP_033447293.1\|201012_202536_+\|M48-family-metalloprotease	gnl\|CDD\|227122	COG4783, COG4783, Putative Zn-dependent protease, contains TPR repeats [General function prediction only].	6.77969e-93
NZ_CP049918.1\|WP_003814188.1\|206308_206638_+\|AzlD-domain-containing-protein	gnl\|CDD\|226827	COG4392, COG4392, Predicted membrane protein [Function unknown].	7.8037e-15
NZ_CP049918.1\|WP_010931455.1\|205556_206306_+\|AzlC-family-ABC-transporter-permease	gnl\|CDD\|224215	COG1296, AzlC, Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism].	6.63749e-32
NZ_CP049918.1\|WP_033447311.1\|214727_215453_-\|arginyltransferase	gnl\|CDD\|234939	PRK01305, PRK01305, arginyl-tRNA-protein transferase; Provisional.	6.96118e-140
NZ_CP049918.1\|WP_003814170.1\|213637_214687_-\|quinone-dependent-dihydroorotate-dehydrogenase	gnl\|CDD\|235388	PRK05286, PRK05286, quinone-dependent dihydroorotate dehydrogenase.	0
NZ_CP049918.1\|WP_003814174.1\|211547_212525_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein-BugD	gnl\|CDD\|270294	cd13576, PBP2_BugD_Asp, Aspartic acid transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	2.54496e-161
NZ_CP049918.1\|WP_003814195.1\|204194_204407_-\|zinc-finger-domain-containing-protein	gnl\|CDD\|226826	COG4391, COG4391, Uncharacterized protein conserved in bacteria [Function unknown].	5.98518e-12
NZ_CP049918.1\|WP_003814183.1\|208810_209611_+\|EI24-domain-containing-protein	gnl\|CDD\|377798	pfam07264, EI24, Etoposide-induced protein 2.4 (EI24). This family contains a number of eukaryotic etoposide-induced 2.4 (EI24) proteins approximately 350 residues long as well as bacterial CysZ proteins (formerly known as DUF540). In cells treated with the cytotoxic drug etoposide, EI24 is induced by p53. It has been suggested to play an important role in negative cell growth control.	1.28978e-07
NZ_CP049918.1\|WP_003814193.1\|204453_205374_-\|branched-chain-amino-acid-transaminase	gnl\|CDD\|235841	PRK06606, PRK06606, branched-chain amino acid transaminase.	0
NZ_CP049918.1\|WP_033446149.1\|199203_200076_+\|cytochrome-c-oxidase-assembly-protein	gnl\|CDD\|378238	pfam09678, Caa3_CtaG, Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG). Members of this family are the CtaG protein required for assembly of active cytochrome c oxidase of the caa3 type, as found in Bacillus subtilis.	5.4923e-46
NZ_CP049918.1\|WP_003814172.1\|212911_213490_+\|TIGR01841-family-phasin	gnl\|CDD\|130900	TIGR01841, hypothetical_protein, phasin family protein. This model describes a family of small proteins found associated with inclusions in bacterial cells. Most associate with polyhydroxyalkanoate (PHA) inclusions, the most common of which consist of polyhydroxybutyrate (PHB). These are designated granule-associate proteins or phasins; the member from Rhodospirillum rubrum is an activator of polyhydroxybutyrate (PHB) degradation. However, the member from Magnetospirillum sp. AMB-1 is called a magnetic particle membrane-specific GTPase.	3.19978e-10
NZ_CP049918.1\|WP_003814179.1\|209664_210477_+\|competence/damage-inducible-protein-A	gnl\|CDD\|223986	COG1058, CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only].	2.67138e-63
NZ_CP049918.1\|WP_003814197.1\|203749_204172_-\|SnoaL-like-domain-containing-protein	gnl\|CDD\|379209	pfam13474, SnoaL_3, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	1.07341e-14
NZ_CP049918.1\|WP_165645713.1\|210635_211484_+\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	2.38878e-72
NZ_CP049918.1\|WP_003814206.1\|198018_199113_+\|porin	gnl\|CDD\|238208	cd00342, gram_neg_porins, Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers are stabilized by hytrophillic clamping of Loop L2. Loop 3 bends into the pore, creating an elliptical constriction of about 7 x 11A, large enough to allow passage of a glucose molecule without steric hindrance. Removal of the C-terminal residue (usuallly F) destabilizes the trimer and removal of the 16th beta-sheet abolishes trimerization. Unlike typical membrane proteins, porins lack long hydrophobic stretches. Short turns are found at the smooth, periplasmic end, longer irregular loops are found at the rough, extracellular end. C-terminal residue forms salt bridge with N-terminus.	8.91426e-53
NZ_CP049918.1\|WP_003814199.1\|202632_203733_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|223506	COG0429, COG0429, Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only].	1.70568e-90
NZ_CP049918.1\|WP_003814203.1\|200097_200937_-\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	gnl\|CDD\|224131	COG1210, GalU, UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane].	2.75704e-156
NZ_CP049918.1\|WP_161782648.1\|206995_208354_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|236722	PRK10590, PRK10590, ATP-dependent RNA helicase RhlE; Provisional.	2.80661e-156
NZ_CP049918.1\|WP_003814164.1\|215489_216254_-\|leucyl/phenylalanyl-tRNA--protein-transferase	gnl\|CDD\|234720	PRK00301, aat, leucyl/phenylalanyl-tRNA--protein transferase; Reviewed.	3.07893e-129

>NZ_CP049918.1|WP_003814188.1|206308_206638_+|AzlD-domain-containing-protein
MSDRDLYVYGAILLLTLCSVLTRAGFMLFGDYIPLPDGVRRALRYAPAAALTAIVVPDLLPWKAGLGPAFDYKLVAGVLAIMAFLRTRSAVLVIVVGMVALWGLRWLAG
>NZ_CP049918.1|WP_010931455.1|205556_206306_+|AzlC-family-ABC-transporter-permease
MASDPATSALEDARQARQERADAFRAGVRAITPALIATGTWGMVTGVAMVKSGLTESMALAMTLLMYAGSAQLTSLPLIATGAPLWLIFAAGFVVNLRFLIFGAALHPYFRHMSWPRRLGLGYFTTDMGFVLFMPRFGDAAERGTREQLWFFLGTVAPGWMVWQVTSIVGIYLGSLVPEAWSLDFAAVLALLAITVPLANSKPMLVSMLAAGMVAWVGQLLPLRLGLAAAVVAGIVAGIWAERFFKGRT
>NZ_CP049918.1|WP_003814193.1|204453_205374_-|branched-chain-amino-acid-transaminase
MSMSDRDGFIWYDGKLVPWREATTHVLTHSLHYGLSVFEGVRAYETAAGTAIFRLQDHTNRLFNSAHIYQIPLPYDRDTLNEAQREVVRANGLASCYLRPLAFYGSEKMGVSPKGAQVHVAIAAWPWGAYLGETALAQGIRVKVSSFARQHVNVTMPRAKVATTYANSIIANAEALQDGYDEALLLDTEGFVAEGAGENIFIVKDGVLCEPEIASALTGITRSTIHALAADLGLRVVTKRLTRDDVYIADEAFFTGTAAEVTPIREVDNRQIGAGRRGPVTEKLQQAFFDLVNGRNPKYQHWLTPV
>NZ_CP049918.1|WP_003814195.1|204194_204407_-|zinc-finger-domain-containing-protein
MTAAAQAAVPAHDAIEVGAEDLPVYCPGPKAPLWSMHPRVFLDVTHTGQASCPYCGAAYRLKPGTVVHGH
>NZ_CP049918.1|WP_003814197.1|203749_204172_-|SnoaL-like-domain-containing-protein
MFATPDEAEHAFYEALEHADLDRLMQVWSDDEEIACIHPGGLRIVGHTAVHESWQQVLANGPLHLRPLRPLVMQSMMCAVHVLVEQVTVMTREGAQFANCYATNVYHKGPAGWRMVLHHASQAPAEAGVLDLHDFPDRLH
>NZ_CP049918.1|WP_003814199.1|202632_203733_-|alpha/beta-fold-hydrolase
MAASRIDLTPCPVPPWLPDRHSQTVYAAVLAQYHRIAFVRERVDTPDTDFVDFDWTGPGLFPHKTAEGAAPAGPAPQGNGRIAAARWITATDWASLPQTADTPALILFHGLEGGSTSRYAQSIAHYFRARGWIVVIAHFRGCSGVPNRLARAYYSGDSAEVGFMLDTVRARIPHARWHAVGVSLGGNALLKYLGEHHDEASWLAAAAGVSVPLDLVAGGKALCTGFIARRIYTAYFLKTMRRKVLEKAKRFPGAIDVIRIAHARDLRDFDDAYTARMHGYRNALDYWTRASSKPWLAHIKTPTLVLNARNDPFLPESALPIPAECSDSVLLHQPAEGGHAGFPTGPFPAHLNWLPQRLGRFFEMGS
>NZ_CP049918.1|WP_033447293.1|201012_202536_+|M48-family-metalloprotease
MNRWNLTFSPSLGRRALAAALSLALGLPVAPAVGQPSGLPSMGAASASELSPMLERQLGDAIMAQGRRDPTYINDPELRQYLTTMGRKLASFAPGAAPHVEMFGVRDPEINAFAMPGGYIGVNTGLIVSSASESELAAVLAHEIGHVAQRHIARGMTQQNQNSMVMLASLAGALLAALAGGGGNLAMGVAAFGQAAAINRQLGFSRDAEREADRTGLQMLAKAGYDPDGMAQMFSRLMNASRLNEGMGGGAWASTHPLSIDRMSDVQNRIRGLPGSRHVDSDDFWFIRAKMRVAQGRDALSLRTAQQQLQDESRALSGVRQAAAFYGLALYAFQRNDLAQARAFLEQAGAGGRSSPQMARLAIDVAVAAKDNDQALALALAQAAVKRWPDRKALGIAYAQALQAAGRHADAQAYLRERARQWGGDEPSLYQLLAQSEERTGHPVDARRNMARYYDLTGAYASAESQLQQARGLSNDFYEQSQIDVSIREIKQKLADERQLLERFKSG
>NZ_CP049918.1|WP_003814203.1|200097_200937_-|UTP--glucose-1-phosphate-uridylyltransferase-GalU
MQVVRKAVFPVAGMGTRFLPATKAMPKEMLPVVDKPLIQYAVEEAVAAGITDLIFVTGRNKRAIEDHFDAAPELETDLEAKGKHELLALVRDILPAHVNCLYIRQSAPLGLGHAVLTAAPAVGNEPFAVLLADDLIDADTPVLKQLIDVAVARQGSVLGVQEVPREDTRKYGIVASQPVDARTERVTHIVEKPAPEQAPTTLAVVGRYVLEAAIFDHLRATTVGAGNEIQLTDGIAALLRERDVYAHRYDGKRYDCGSKAGMFQATVALGRKYHGLIPE
>NZ_CP049918.1|WP_033446149.1|199203_200076_+|cytochrome-c-oxidase-assembly-protein
MDWLEWLIPWEFSPTLVAAFVVAIVLFVRGQRVHHVTAARQWLFWSGMVLLYLSMHTRLDYYAERMFFIHRAQHLVLHHLGPLLVMAAFPGSAMRAGLPMAWRVRLRDFLRTGTGRALAAVLTHKVFVPTLFVFLVLVWLLPSVQFYSMLDWRLYRLMNWSVVISGFMYWNLILDRRPSPPAAMTPGGRVLSPALTMAPQMVAGAVIAFTERDLYPLFELCGRAIAMSAQTDQTIGGLTMWIPAALVEVVGLLVALGTLMRLSGKGRLRPQDRAARARQRAAGSPTSPAA
>NZ_CP049918.1|WP_003814206.1|198018_199113_+|porin
MRRLLVVAAMAAGSSSVFWSVAPARAANQLELYGVVDVGLATTRVSGLGTRQQVLGGGQTDNLWGLRGTEELDGGWRASFGLESGFDAANGTRNDDARLFDYGTWVGLGHAGVGELSLGRQQSIGLQYGGQLEIASWRDMGMGALFKASDNYRVNNLVNYLSPEFSGWQWGVGYAFDVESGDTGRFDRSPAFSTGLKYEDGPLLAAFTWDKLNLHDTSATGGRSPQALQAGFTYDFEALKMALAWSRQRNGFVGLNGGGQIGLGPEPFAHGGAINAWLLGLEVPVHGNGAWLVQGSMARPDWHWANGQQASKAYVVTLGYRQDLSARTSLYAYGGYMKGYDPEDPFASDVGRATRFGVGMTQRF
>NZ_CP049918.1|WP_161782648.1|206995_208354_+|DEAD/DEAH-box-helicase
MLKSIADTGYTNPTPIQAQAIPVVVEGRDVMGAAQTGTGKTAAFTLPILHRLMPLANTSASPARHPVRALILTPTRELADQVYESVKRYSLHTPLRSAVVFGGVDIGPQKEALRRGCEVLVATPGRLLDHVEQKNVNLGQVGILVLDEADRMLDMGFLPDLERIIRLLPAQRQGLLFSATFSNEIRKLGRSYLNHPVEIEVAARNATADTVTQIAYQMHGDTKRAAVVHLVKSRGLKQVIVFSNTKIGTARLARQLERDGVKAESIHGDKTQGDRMKALEAFKAGDLEVLVATDVAARGLDVAGVPCVINYDLPYNAEDYVHRIGRTGRAGASGEAIALFTADEERYLLDIEKLIKRQVPRGKLELPADLVARSHGRDRDAPRERERGADRHRGERRTSGAAAPRQPVDELFYKPYEPANGQPASPETPKQEGRSNAPKRQLAVLLGGSRKG
>NZ_CP049918.1|WP_003814185.1|208365_208749_-|thioredoxin-family-protein
MPLHVPGSDIPTLRAALARSDAWLVACFCAAWCDTCQQYRPKLLELARARPGHTFAWIDIEDHPDLLGEEDVENFPTLLVQAHGKVLFYGPMLPHIGHLERLLDSLDPQGRPVATGLPDVARLLAAA
>NZ_CP049918.1|WP_003814183.1|208810_209611_+|EI24-domain-containing-protein
MTVPRPESIIPPAGNAATGAAGIARAFKRALVSQCHPNMLFAVLLPFLIALLGAILLLWLFWTPLNEWLRFEASQWQAINQVDDWMVAAGLFSLKIYLVPVIAAAILLPISGILGLAIAAVFVMPLVLRHVGGREYAGLARQGRNATAVSVWNALWVSLAFGAGWLLTLPFWLIPPMAVILSVFWWAFAFTRMLRLDAIVEHASPAERAILLKRHNSGFWLIGLVCSLLNLLPPAWIILPVFSGLVYAHYGLDALQRLRQERTIDV
>NZ_CP049918.1|WP_003814179.1|209664_210477_+|competence/damage-inducible-protein-A
MAAESARRIGLIIVGDEILSGRRQDKHFSKVVELLGARGLKLSWAELLPDDRATLAAVLRRSFASGDIVFSCGGIGGTPDDHTRQAAAEALDLPLALHPEAEQAIALRAAEMAAKGQGTADMGTPENQQRLQMGMFPRGCEIVPNPYNRIPGFFVRDHTFVPGFPVMAWPMLEWTLDTRYRALHHQVRHAEHSFLVFDMPESRITPAMVEIEQRWPGVRAFSLPSVGETGGPSHIDLGVKGEPEAAAQALAFLRAEVVRLGGKLAPPAQN
>NZ_CP049918.1|WP_165645713.1|210635_211484_+|IclR-family-transcriptional-regulator
MSRIPNATARGPGSHSDDGAGQHPIAIQVIDRAMRLLDALAAQPEPVTLKELSATTGLHASTAHRILNDLVVGRYVERVDNGLYQLGMRLLELGSLVKGRLNVREAAIGAMRSLHKQTGQTINLSVQQGDEIVYIDRAWSERSGMQVVRAIGGRAPLHLTSTGKLFLSTYDTRLVRAYALRTGLAGHTRNSLTELDRLERELALVRRHGYARDNEELELGVRCIAAGIYDDTGKLVAGLSISAPAERLQDEWIRLLVDAAASISEALGYEPGVNGIHTPAAA
>NZ_CP049918.1|WP_003814174.1|211547_212525_-|tripartite-tricarboxylate-transporter-substrate-binding-protein-BugD
MPPISRKLSALFAAVALTGAGTALAEYPERPVNMVVPFAAGGPTDNVARSLAESMRPTLGETVVVENKGGAGGTIGTTQVARAQPDGYSILLMHAGFSTAPSLYKNPGYEPYTSFEPIGLVVDVPMTIIARGDFPPNNIKELAEYVKKNADKISLANAGIGAASHLCGTMLVEALGVNLLTIPYKGTAPAMNDLLGKQVDLMCDQTTNTTQQITSGKVKAYAVTSLKRVPTLPDLPTMDESGYKGFEVGIWHGMWAPKGTPKPVVDKLVKSLQAGLADPKFQERMKQLGAEVLTNEANPEALQAKVKQQVPQWAELFKKAGVEKQ
>NZ_CP049918.1|WP_003814172.1|212911_213490_+|TIGR01841-family-phasin
MSAIPQQVLARQKATVNSLVAAQSAMFAGFEKLVDLNLKVVRATLDEVAQQSQQAAELKDPQDVASFTSGLVQPGAEKALAYGKHVYDIVAGVQAELAQLAEAQIAEGQQQLTEAVEQFSKNAPTGSESAVALIKSSLATANSAYDSLTKAAKQAAEVAESNLNAAANASFKAASDAAEVATKAAGRNRRAA
>NZ_CP049918.1|WP_003814170.1|213637_214687_-|quinone-dependent-dihydroorotate-dehydrogenase
MSILFHAYPLARPALFAMDAETAHEVTLAQLQRAYDCGLTRKLLHAQPEAPATLMGLSLRNPVGLAAGLDKNGAHIDALGNLGFGFVEVGTVTPRAQPGNPKPRMFRLPRANALINRLGFNNQGLDAFIANVQRSQWRSQGGILGLNIGKNADTPIERAAEDYLIGLAGVYPHADYVTVNISSPNTKNLRALQGGDELSALLGQLQERRLALADQHQRHVPLAVKIAPDLSDDQIDAIAEILPRHGIDGVIATNTTLARDAVQGLPHAEEAGGVSGAPVHELSLRVIERLRSRLGDAVAIIGVGGILSGRQASEKMAAGAQAVQLYTGLIYRGPALVGECVRALAQGSR
>NZ_CP049918.1|WP_033447311.1|214727_215453_-|arginyltransferase
MSQLKELPFSTLQFYATAPYPCSYLPGRQARSQVAAPGHLINAGTYSQLVEQGFRRSGLFTYRPHCDNCHACVPVRVDAARFEPNRTQRRAWRSHQALRAFVAELAWSPEHYDLYTRYQQGRHPGGGMDEDSRTQYAQFLLTTRVNTRLVEFRTPQGQLAMISIIDVLDDGLSSVYTFYDPDMAGSLGTYSILWQIEQCRTLDLPWLYLGYWIADSRKMAYKANFRPLQMHVDGAWRETPP
>NZ_CP049918.1|WP_003814164.1|215489_216254_-|leucyl/phenylalanyl-tRNA--protein-transferase
MKLPWLAADTPFPPVEQALRDPDGLLAAGADLSPERLAQAYAHGIFPWYAEGEPILWWSPDPRMVLACADFAPSHSLRKRLRALARTEHDPAARLQVRVDTAFARVLHECAAPRHGQPGTWISPAVQQAYRSWHAAGFVHSIETWIDGELAGGLYGVSLGRMFYGESMFARATDASKIALAHLVAFLRRHQVAWIDCQQQTGHLARLGARPVPRARFIEHIAHAVAQPRLPWRSGRLDSAGMLHPLPPANGVMM

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Crispr_ID: NZ_CP049918_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049918_2

1018991-1019114

Orphan

Consensus_repeat	Method
TTTTTTTGCCGCCGGGCCGTCCCAAGGCAAAAAGGCCCCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049918_2

>merge|NZ_CP049918|2|1018991-1019114|CRISPRCasFinder
TTTTTTTGCCGCCGGGCCGTCCCAAGGCAAAAAGGCCCCCTTTGGGGGCAGCAAGCCCGCGCAGCGGGCGCAGCGTGGGGGCGTTTTTTTGCCGCCGGGCCGTCCCAAGGCAAAAAGGCCCCCT

>NZ_CP049918|2|2|1018991-1019114|CRISPRCasFinder
TTTTTTTGCCGCCGGGCCGTCCCAAGGCAAAAAGGCCCCCT	TTGGGGGCAGCAAGCCCGCGCAGCGGGCGCAGCGTGGGGGCG
TTTTTTTGCCGCCGGGCCGTCCCAAGGCAAAAAGGCCCCCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049918.1\|WP_010928268.1\|1019562_1020879_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049918.1\|WP_003812728.1\|1019302_1019566_+\|membrane-protein	unknown	unknown	unknown
NZ_CP049918.1\|WP_003812742.1\|1012756_1013701_+\|hydroxymethylbilane-synthase	unknown	unknown	gnl\|CDD\|234612
NZ_CP049918.1\|WP_003812748.1\|1009906_1010788_+\|succinate--CoA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|180194
NZ_CP049918.1\|WP_003812722.1\|1020875_1021499_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049918.1\|WP_003812732.1\|1018091_1018787_+\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223257
NZ_CP049918.1\|WP_015064053.1\|1024398_1026015_+\|Flp-pilus-assembly-complex-ATPase-component-TadA	unknown	unknown	gnl\|CDD\|227297
NZ_CP049918.1\|WP_010930986.1\|1011918_1012638_+\|TerC-family-protein	unknown	unknown	gnl\|CDD\|163429
NZ_CP049918.1\|WP_003812717.1\|1022989_1024402_+\|secretory-apparatus	unknown	unknown	gnl\|CDD\|333965
NZ_CP049918.1\|WP_165645755.1\|1021495_1022164_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|184854
NZ_CP049918.1\|WP_003812707.1\|1028829_1029816_-\|homoserine-kinase	unknown	unknown	gnl\|CDD\|235369
NZ_CP049918.1\|WP_003812745.1\|1011064_1011760_+\|TerC-family-protein	unknown	unknown	gnl\|CDD\|163429
NZ_CP049918.1\|WP_033446517.1\|1013733_1014522_+\|uroporphyrinogen-III-synthase	unknown	unknown	gnl\|CDD\|119440
NZ_CP049918.1\|WP_050489421.1\|1014559_1015744_+\|uroporphyrin-III-methyltransferase	unknown	unknown	gnl\|CDD\|235899
NZ_CP049918.1\|WP_003812713.1\|1026011_1026857_+\|membrane-protein	unknown	unknown	gnl\|CDD\|227300
NZ_CP049918.1\|WP_165646053.1\|1027763_1028471_+\|DUF192-domain-containing-protein	unknown	unknown	gnl\|CDD\|376876
NZ_CP049918.1\|WP_010928273.1\|1026867_1027764_+\|type-II-secretion-system-F-family-protein	unknown	unknown	gnl\|CDD\|224975
NZ_CP049918.1\|WP_003812734.1\|1017371_1017908_+\|inorganic-diphosphatase	unknown	unknown	gnl\|CDD\|179262
NZ_CP049918.1\|WP_010926375.1\|1015747_1017343_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273126
NZ_CP049918.1\|WP_003812730.1\|1018813_1018945_+\|entericidin-A/B-family-lipoprotein	unknown	unknown	gnl\|CDD\|227797

Protein	Function_ID	Function_description	E-value
NZ_CP049918.1\|WP_165645755.1\|1021495_1022164_+\|hypothetical-protein	gnl\|CDD\|184854	PRK14852, PRK14852, hypothetical protein; Provisional.	0.00321636
NZ_CP049918.1\|WP_003812742.1\|1012756_1013701_+\|hydroxymethylbilane-synthase	gnl\|CDD\|234612	PRK00072, hemC, porphobilinogen deaminase; Reviewed.	8.72133e-165
NZ_CP049918.1\|WP_003812748.1\|1009906_1010788_+\|succinate--CoA-ligase-subunit-alpha	gnl\|CDD\|180194	PRK05678, PRK05678, succinyl-CoA synthetase subunit alpha; Validated.	0
NZ_CP049918.1\|WP_003812732.1\|1018091_1018787_+\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	3.98038e-90
NZ_CP049918.1\|WP_015064053.1\|1024398_1026015_+\|Flp-pilus-assembly-complex-ATPase-component-TadA	gnl\|CDD\|227297	COG4962, CpaF, Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion].	1.81087e-139
NZ_CP049918.1\|WP_010930986.1\|1011918_1012638_+\|TerC-family-protein	gnl\|CDD\|163429	TIGR03717, R_switched_YjbE, integral membrane protein, YjbE family. Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family commonly are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains protein YjbE from Bacillus subtilis. A transport function is proposed.	3.14656e-77
NZ_CP049918.1\|WP_003812717.1\|1022989_1024402_+\|secretory-apparatus	gnl\|CDD\|333965	pfam00263, Secretin, Bacterial type II and III secretion system protein.	2.91349e-53
NZ_CP049918.1\|WP_003812707.1\|1028829_1029816_-\|homoserine-kinase	gnl\|CDD\|235369	PRK05231, PRK05231, homoserine kinase; Provisional.	0
NZ_CP049918.1\|WP_003812745.1\|1011064_1011760_+\|TerC-family-protein	gnl\|CDD\|163429	TIGR03717, R_switched_YjbE, integral membrane protein, YjbE family. Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family commonly are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains protein YjbE from Bacillus subtilis. A transport function is proposed.	1.70286e-69
NZ_CP049918.1\|WP_033446517.1\|1013733_1014522_+\|uroporphyrinogen-III-synthase	gnl\|CDD\|119440	cd06578, HemD, Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in the human uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria, a recessive inborn error of metabolism also known as Gunther disease.	1.14143e-44
NZ_CP049918.1\|WP_050489421.1\|1014559_1015744_+\|uroporphyrin-III-methyltransferase	gnl\|CDD\|235899	PRK06975, PRK06975, bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed.	5.44489e-54
NZ_CP049918.1\|WP_003812713.1\|1026011_1026857_+\|membrane-protein	gnl\|CDD\|227300	COG4965, TadB, Flp pilus assembly protein TadB [Intracellular trafficking and secretion].	3.18806e-34
NZ_CP049918.1\|WP_165646053.1\|1027763_1028471_+\|DUF192-domain-containing-protein	gnl\|CDD\|376876	pfam02643, DUF192, Uncharacterized ACR, COG1430. Two structures have been solved for members of this large (>500 members) family of bacterial proteins present mostly in environmental bacteria and metagenomes (distant homologs are also present in several Plasmodium species). TOPSAN analysis for Structure 3pjy shows that there is much similarity with the other solved structure, Structure 3m7a, solved for UniProt:Q2GA55 (Saro_0823), a homolog of Thermotoga maritima TM1668, UniProt:Q9X1Z6., The homolog in Caulobacter crescentus (CC1388), UniProt:Q9A8G6, is associated with CspD, a cold shock protein (CC1387), UniProt:Q9A8G7. However, the genomic context of UniProt:Q2GA55 is most conserved with a putative xylose isomerase, suggesting a possible role in extracellular sugar processing. Saro_0821, UniProt:Q2GA57, is annotated as an AMP-dependent synthetase and ligase. Structure 3m7a structure corresponds to the C-terminal (27-165) fragment of the YP_496102 (Saro_0823) protein and it is structurally unique, as the best hits from Dali have a Z-score of 3.8 (1nt0, 2j1t, 3kq4) and it is thus a likely candidate for a new fold. Interestingly, many of the top Dali hits are involved in sugar metabolism. There are no obvious active site-like cavities on the protein surface of 3m7a (http://www.topsan.org/Proteins/JCSG/).	8.25685e-09
NZ_CP049918.1\|WP_010928273.1\|1026867_1027764_+\|type-II-secretion-system-F-family-protein	gnl\|CDD\|224975	COG2064, TadC, Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion].	4.96947e-19
NZ_CP049918.1\|WP_003812734.1\|1017371_1017908_+\|inorganic-diphosphatase	gnl\|CDD\|179262	PRK01250, PRK01250, inorganic diphosphatase.	2.68623e-113
NZ_CP049918.1\|WP_010926375.1\|1015747_1017343_+\|hypothetical-protein	gnl\|CDD\|273126	TIGR00540, TPR_hemY_coli, heme biosynthesis-associated TPR protein. Members of this protein family are uncharacterized tetratricopeptide repeat (TPR) proteins invariably found in heme biosynthesis gene clusters. The absence of any invariant residues other than Ala argues against this protein serving as an enzyme per se. The gene symbol hemY assigned in E. coli is unfortunate in that an unrelated protein, protoporphyrinogen oxidase (HemG in E. coli) is designated HemY in Bacillus subtilis. [Unknown function, General].	5.88418e-71
NZ_CP049918.1\|WP_003812730.1\|1018813_1018945_+\|entericidin-A/B-family-lipoprotein	gnl\|CDD\|227797	COG5510, COG5510, Predicted small secreted protein [Function unknown].	8.70055e-07

>NZ_CP049918.1|WP_003812730.1|1018813_1018945_+|entericidin-A/B-family-lipoprotein
MRSKIVLTAFVVFGFVLQGCNTVAGMGKDMSDAGSAITHAAEK
>NZ_CP049918.1|WP_003812732.1|1018091_1018787_+|fumarylacetoacetate-hydrolase-family-protein
MDYVFPPSPPAAVPVAGGNARFPVRRVYCVGRNYAEHAKEMGFTGREDPFFFCKPADAILSVADGATGEMPYPPKTANLHYEMELVVVLGKGGRDLTVEQADECVWGYALGLDMTRRDLQGEAKKQGRPWEVGKAFDLSAPLGPIHPRSAVGTLDKGAIWLDVNGERKQSSDISQMIWNIPESIAYLSGLFELQPGDIIFTGTPEGVGAVVKGDVIVGGVEGLGELRVRIA
>NZ_CP049918.1|WP_003812734.1|1017371_1017908_+|inorganic-diphosphatase
MSLDRVAPGKKLPDDFNVIIEIPMNADPVKYEVDKESGAIFVDRFMLTAMHYPCNYGYIPQTLSEDGDPADVLVLTPFPIQIGAVVRCRAIGVLEMDDESGGDAKLLAVPIEKLYPPYRNIKSYEDLPAEDVSRIQHFFEHYKDLEKGKWVKVKGWKGVDAAHEEIVRSAERYAKGQA
>NZ_CP049918.1|WP_010926375.1|1015747_1017343_+|hypothetical-protein
MRTWFWTLLLAVVAVALAVVLRAHAGNVLLLVWPWRIELSLTLTVLLLVAAFVTLYIGLRLLAWLVAIPDRLRAWRGRRAQERDHELLERGWIGLLEGRFAQAEKDLSKLFDQTKVRSRRVLAALSGARAAHNLGEYERRDRMLESAREQAGEDAGLQEATATVSADMLLDQGRAQQALDLLEPLQDGGARHLHTMRLLLRAETALQHHERVFMLARGLLRRNAIGKAEAEQLIDSAGAARLRAGMAVDQWRPIWKDLKSDERLLPNIALAGAAAFEDAGEASEAARILEAAVAVKFNPALVAAYARCDAAQVPHRLAKAETWLQQRPADTDLLTALGLLCLNGQLWGQAERYLQRSVSRRNDPQAHALLGSLYDRLDRPADAARHWRQATAARVALPVLAADIALPAADTKADPAWLDAEREYVPNMSEYTAPVIADAPPEVEPGAVDYVLDPDARAAGEHEPASAVAPEPVSVPPRTAIDIEDYFDSAPIPAAAIEAPVSSYRAGGDDEQPAKPGGAVSSAGPASGDKA
>NZ_CP049918.1|WP_050489421.1|1014559_1015744_+|uroporphyrin-III-methyltransferase
MTDNTSATPPGIVPGTPGTAAADEAVASQSRKGKGVNSTLVTALIIVILLAVGLGWAAWLQRKQFVSAGQEVAARLNTLGAELTQSRNDMREALALAQAQSGKVAELEGKVREAQSQYSALQQALQNLNDGASDEMLANDIERLITIASQQLRLAGNVSNAIVALETAQARLARADRPRFASLQQSINGDLDRLRAVGVVDIAAQSARIDRLVALVGRAPLLVPDAAAPGVTAVPQANEAVPASVDPGADLPADAAWWHRWQAEIASWPGRAGSALAHELGDLIRVQRVDQPTALLLSPEQAGQLRSTLRQRLLTAQLSMLMRQPAVWKSELDAVAATLAQYFDGKAPDTVAALALARELGQVEIAVRVPDVADSLNGIAALRAAGFNADGQQD
>NZ_CP049918.1|WP_033446517.1|1013733_1014522_+|uroporphyrinogen-III-synthase
MSQIAILTRPQGRNGALAQRLHEAGWQTLCLPALRIEPLPPENGAVPLPRDYDLVVFVSGNAARLYLEQLGERGQLPWPAGAVAATVGPASARALLDSGQFGADTTVLHPAETAPTHDSEALWALLRARPALPRRALLVRGTQGRDWLADRLAAAGVEVSRHAVYRRRPAPWAQEGRQRLRDWARAGERPTWLLTSGEGIDALVQGLREEQLLDWWLQGRFVVTHPVLAERLRALAGGGADAPMVKNCMPADEAIFATFVAA
>NZ_CP049918.1|WP_003812742.1|1012756_1013701_+|hydroxymethylbilane-synthase
MAAVERLTIATRASRLALWQAEHVRDLLRARYPACSVELLTLTTRGDQILDRTLSKVGGKGLFVKELETALLDGRADLAVHSLKDVPVDLHAPFELSCVLERADPRDAFVSNDYGSLADLPPGAAVGTSSLRRESQIRARYPHLVVKPLRGNLDTRLGKLDNGDYAAIVLAAAGLERLGLAARIRALLEPADSLPAAGQGALGIEILQGRADVRAMLAPLGDAATLACVTAERAVSRMLGGSCQVPLAAYARIDGDELALRALVAAPDGRRIVRAERRGPRDQAQAIGESAARDLLADGADAILAELLPTSPAP
>NZ_CP049918.1|WP_010930986.1|1011918_1012638_+|TerC-family-protein
MLEFFQTLSWAAVFQIILIDILLGGDNAVVIALACRNLAPKQRMQGILWGTAGAIILRVVLIAFALTLLNIPFLKVVGGLLLVWIGVKLLVPEDEGHDSIKGGTSIVAAVKTIIIADFVMSLDNVIAIAGAAQNAHADHQIGLVVFGLVVSVPIIIWGSTLVLKLIDRFPMVVTFGAALLGWIAGGMLITDVFVVRQFGEQPSAVKIGVEIAGALLVVLLGRWLASRKTASKESVNESA
>NZ_CP049918.1|WP_003812745.1|1011064_1011760_+|TerC-family-protein
MELSSAAFWIALLQIIWVNILLSGDNAVVIALAARSLPPDQQKKAIVVGSAAAIVMRIVLTLVAAKLLLLPWLKLIGAALLVYIGVSLLLPEGEDDGAEKGHGSLLVAIRTIMIADLVMSLDNVVAVAAAAMGDTTLLVLGLAISIPLVIFGSALLLKVIERFPIIVWVGAALLGFIAGELLVGDPALEESVARIDTMLGVTQHDFALMVGAIGAILVLALGKIFQARQRA
>NZ_CP049918.1|WP_003812748.1|1009906_1010788_+|succinate--CoA-ligase-subunit-alpha
MSILINKDTKVITQGITGKTGQFHTRMCREYANGKAAFVAGVNPKKAGEDFEGVPIYANVKDAKADTGATVSVIYVPPAGAAAAIWEAVEAELDLVICITEGIPVRDMLEVKNRMQAMNSKTLLLGPNCPGLITPDEIKIGIMPGHIHRKGRIGIVSRSGTLTYEAVAQVTELGLGQSSAVGIGGDPINGLKHVDVLKLFNDDPDTDAVIMIGEIGGPDEVNAAQWAKDNMKKPVVGFIAGVTAPAGKRMGHAGALISGGADTADAKLEVMEACGIRTTRNPSEMGKLLKSVL
>NZ_CP049918.1|WP_003812728.1|1019302_1019566_+|membrane-protein
MSVKQRQLGQGMTEYIIVVALVAVAAIAVYQLFGQVVRSQTAAMARELAGEDGSAQARAAQSAAGRAASQTRARSLKSFTGNAQGAK
>NZ_CP049918.1|WP_010928268.1|1019562_1020879_+|hypothetical-protein
MRPTRAAVTRQAGQALALGLALMALAGMAWLALYGLGQRAGARAQLLRATDAAAYSGAVVQARALNLLAYIHRAQVGHQVALAHLASLAAWARFAQTQAARRTAQNPPVALIGLLFGPRAARGYGAAHDALAGDLMQAYAAHDELAHRVLQQAADTLARDARATRDATMRAVLRAHYPQGDDGLTLEVLRDDWPGYLRRVPGTSARGLRGWAQRAAGYFDFLQPRDFTREGNWIVSPRCPTRRHELRRRGVTWLDRDGRWGASDTLSFHAVRSNRWIGCYFREYAMGWGLAADSGATRAGPHVLRAPEDFSQQDFWRWVHRHTSWSLLGGRHNPLALSYAASRRLSPGGRGLPAVYEPASSSEAAVGFEIRTQRREEGIVLSARAAGQSHFSLPPGTSVARGRPDVLFLPYWQARRAAADAALPMAARRTVRGPESRP
>NZ_CP049918.1|WP_003812722.1|1020875_1021499_+|hypothetical-protein
MRGAAFSRRQRGQALAEALPLLAMLLLAWAAVAWLGTLRHQALRLGQHSRVAAFMAAAAAPSAPRTATLARQAGLAGRTAADGMPALLARDWLQVDTRLLHAQAAEPAAMPGGLLREGAITAALRGVTVLAIGPGHASDARAGNDRLARSVAGWQLAHRAAAPAVAATRRRVRPVEAAWGLRDAGQDWLRTWADMASADGAVLRRQP
>NZ_CP049918.1|WP_165645755.1|1021495_1022164_+|hypothetical-protein
MTPAHLAASASASASAWLHLPPGVVAAALAGQIQVFGVPAEVRVFHAPQGIDALLAHFATRHAELRDLTVLPGLAVLAGGAGDCTHTISLAPQSGGVEGVAARLCWPRGLPSRQPLADVLLPPHARLRLDVATRDGPVSVAQQVWHWRAVGPTETARWAVRREARLRASGWRLQGAAGPACRCGAPQIWLRAGPQGRERLSLQPALHANGCGMRLLHIGGAP
>NZ_CP049918.1|WP_003812717.1|1022989_1024402_+|secretory-apparatus
MSMRSRLPLHARGWLPWMAVLLAGGSMLWTPGGRAASPAQPAVLRMEVGETQVLAAAGVTRVAVGNGQVLSATVVDGAEVALFARQPGTSSVHIWSGRGARQAYAVEVLPAGRRRLREEVAALLARIPRARSSAVGAHIVIEGSQLSEDDHARIAALAQRYPEVLDFTGRVGWDRMVLLDVQVVELPRQSLRELGLRWDEPAAGGVHAGAVWNGGSAALAPPPGPLAGAAAVRHAGGLLGVNALLSARLSALAQRGEAVLLAQPQLLARSGATASFQAGGELPYRATDKEGNGTTLFKPYGVSLQITPRIDADGAVHARIEVEASSVDPTLALAAGPALRKRRAVTEFNVHSGQTLVLGGFLSRERSHEEKGLPWLSELPLIGALFGARRAALRETELAIFVTPTIVSPSDSFLQRRALLGQMQLDQAFPEAPRLGTGAAADQSADWSRPGGAGSQWRQPPSADAQEGAP
>NZ_CP049918.1|WP_015064053.1|1024398_1026015_+|Flp-pilus-assembly-complex-ATPase-component-TadA
MNVLELALHFEDGARRRMRLAAPVTIGRGAQCALRIANWRVGRVHARLSCLDGAVVLEDLGTLGGTSVNGLRVATHAPVLPDDEIVIGPCLIRVSACCTGSAPSPAPAALPAGGASRGEDLDAALQQSLVLLPHRRRLHAALLEALDLRRRDVSAMSDRMLRAQAEQRLVELVGQDGELPEGIDRAQLCRAVLDEAVGLGPLEPLLADGGISEIMVNRHDEIYVERAGRLQRHAAAFSSEQAVRWVVERIVAPLGRRIDDSSPMVDARLPDGSRVNAVIAPIAIRGVSLTIRKFPRQRPGMADLLAAGSLSEPMARFLLQCVHARKNLLVSGGTGSGKTTLLNILSNAIPEGERIVTIEDAAELRLDHAHLVALEARPANAEGRGRVDIRDLVRNALRMRPDRIVVGECRGAEAFDMLTAMNTGHEGSLTTLHANTPRDALARLEAMTLMAGLDLPLPVVREHIAASIDIIVQQARMADGRRIVTAIVEIAGMESGRIQTQELFRYDARHGFIAGDAPVLADGAWARGPFTGQPEPAP
>NZ_CP049918.1|WP_003812713.1|1026011_1026857_+|membrane-protein
MIWLAMGMAMAAAAWLAWRVLAWSGPAARRYRAVYTQQAGAHLSEVFLFVDPAQLWAAALAMAAAGAAAAWVFSGSAWLAAVAAVALLRLPHLLLGAARRRRLRQLERQLPGALVAMACALRAGAGIAAALRQLVEHGEAPLAQEFGLLLREQRMGVSFDAALARLARRASFESMALVAAALRVAAHTGGNLAETLEGIAQTVSARLQLQDRVRALCAQGRMQAWIVGALPPVLMGVLGRLQPEAMAALWHTLYGWAALALIVVLEGTGIWLIRRIVAIDV
>NZ_CP049918.1|WP_010928273.1|1026867_1027764_+|type-II-secretion-system-F-family-protein
MWLWLAASVAGVAAGWACLALLRGWCGAGWAAACGPEPAPGPPAWRLPRVWRCCRPWLGPLLPWCDRLLSWRMRAVIERAIVRAGCDGLVRPCEVAALSLWMAWLGGVVAVTAASLADGWQAWLPLAPAACAAGAWPALWLRRCAARRRQRIARELPFILDLMTLCAEAGLGMHGALQQAASHGPPGPLRELLVQALCDMRAGMPRRQAMQALAARADSPPVRAWVGALAHADAQGMSLGPMLRGLATRYRAERHQRAERLAMEAPVKMLLPLIACIFPCTFIVLAFPIGYALLQGGL
>NZ_CP049918.1|WP_165646053.1|1027763_1028471_+|DUF192-domain-containing-protein
MRLRLRLARARGWCGRLVGLLGRRRPPGPRSGLLLAPCRAVHTWGMAYAIDVAFVGRDGRVLRLVRGLRPWRGALCVRAVAVVETRVGVIDPEHGGIGRVEAAIQHAARDDGDGNLQGAGQRVGHAHADQQADAQVDEQEHQDPDHAVHQERPFVAPAGNTREEQRLQQPQAVPAHQHGSMPEHGGDDHVKRGEHQQRRTHGRHDGREVVGRGHADAFGQRTGKRQERQQAGGQA
>NZ_CP049918.1|WP_003812707.1|1028829_1029816_-|homoserine-kinase
MAVFTSVSDQDARTLLARFDLGDLVSLRGITAGIENTNFFLNTTRGEYVLTLFEVLTQEQLPFYIELMYHLAARGIPVPQPQTLRDGTRLTTLHGKPCAIVTRLPGGYEPAPGPDHCRLAGATLARAHLAGQDFPLRQPNLRGLPWWQATAPKVLPFLEPGQARLLEAELADQQAHAATALWQSLPSGPAHCDLFRDNVLFAGTFDDPLMGGFIDFYFAGCDTWLFDVAVSVNDWCIVRDTGEFVPELVHGWLQAYAEVRPFTDAERQAWPVMLRAAALRFWLSRLYDFYLPRPAQTLKPHDPRHFERVLQARHRHPAPDLPKSEAAA

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Crispr_ID: NZ_CP049918_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049918_3

1929253-1929411

Orphan

Consensus_repeat	Method
CACCGGCCGGGGCGGAAGCGGCTGAGCCGTTTCGACCTTCGGCCGCGGCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049918_3

>merge|NZ_CP049918|3|1929253-1929411|CRISPRCasFinder
CACCGGCCGGGGCGGAAGCGGCTGAGCCGTTTCGACCTTCGGCCGCGGCACGACCTCCACCTTGGCGACCTCCACCTTGGGAGGCACCACCGGCACCGCCTTGGCCGGCACCGGCCGGGGCGGAAGCGGCTGGGCCGTTTCGACCTTCGGCCGCGGCAC

>NZ_CP049918|3|3|1929253-1929411|CRISPRCasFinder
CACCGGCCGGGGCGGAAGCGGCTGAGCCGTTTCGACCTTCGGCCGCGGCAC	GACCTCCACCTTGGCGACCTCCACCTTGGGAGGCACCACCGGCACCGCCTTGGCCGG
CACCGGCCGGGGCGGAAGCGGCTGGGCCGTTTCGACCTTCGGCCGCGGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049918.1\|WP_010930607.1\|1945432_1946227_-\|putative-hydro-lyase	unknown	unknown	gnl\|CDD\|180100
NZ_CP049918.1\|WP_010930616.1\|1918318_1919293_+\|TRAP-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270320
NZ_CP049918.1\|WP_010926712.1\|1950446_1951496_-\|TRAP-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270320
NZ_CP049918.1\|WP_010926704.1\|1921119_1922871_-\|filamentous-hemagglutinin-transporter-protein-FhaC	unknown	unknown	gnl\|CDD\|377148
NZ_CP049918.1\|WP_138142578.1\|1926658_1927393_-\|molecular-chaperone-FimB	unknown	unknown	gnl\|CDD\|225663
NZ_CP049918.1\|WP_003811089.1\|1919299_1919800_+\|TRAP-transporter-small-permease	unknown	unknown	gnl\|CDD\|377284
NZ_CP049918.1\|WP_033447514.1\|1947694_1948381_-\|DUF2848-domain-containing-protein	unknown	unknown	gnl\|CDD\|371339
NZ_CP049918.1\|WP_003811093.1\|1916756_1918055_+\|TRAP-transporter-large-permease-subunit	unknown	unknown	gnl\|CDD\|129868
NZ_CP049918.1\|WP_033468462.1\|1949716_1950337_-\|TRAP-transporter-small-permease	unknown	unknown	gnl\|CDD\|377284
NZ_CP049918.1\|WP_010926705.1\|1922863_1923961_-\|fimbrial-protein	unknown	unknown	gnl\|CDD\|226069
NZ_CP049918.1\|WP_165645822.1\|1919792_1921094_+\|TRAP-transporter-large-permease-subunit	unknown	unknown	gnl\|CDD\|129868
NZ_CP049918.1\|WP_003811054.1\|1951838_1952747_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP049918.1\|WP_010930609.1\|1940022_1940652_+\|virulence-factors-two-component-system-response-regulator-BvgA	unknown	unknown	gnl\|CDD\|225107
NZ_CP049918.1\|WP_003811061.1\|1948436_1949720_-\|TRAP-transporter-large-permease	unknown	unknown	gnl\|CDD\|224509
NZ_CP049918.1\|WP_003811078.1\|1927642_1928248_-\|fimbrial-protein	unknown	unknown	gnl\|CDD\|339870
NZ_CP049918.1\|WP_003811072.1\|1940660_1944377_+\|virulence-factors-two-component-system-sensor-histidine-kinase-BvgS	unknown	unknown	gnl\|CDD\|182169
NZ_CP049918.1\|WP_165645825.1\|1946284_1947634_-\|amidase	unknown	unknown	gnl\|CDD\|235921
NZ_CP049918.1\|WP_003811094.1\|1916272_1916764_+\|TRAP-transporter-small-permease	unknown	unknown	gnl\|CDD\|377284
NZ_CP049918.1\|WP_165645823.1\|1923974_1926596_-\|fimbrial-biogenesis-outer-membrane-usher-protein	unknown	unknown	gnl\|CDD\|376353
NZ_CP049918.1\|WP_003811069.1\|1944423_1945299_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|376350

Protein	Function_ID	Function_description	E-value
NZ_CP049918.1\|WP_010930607.1\|1945432_1946227_-\|putative-hydro-lyase	gnl\|CDD\|180100	PRK05463, PRK05463, putative hydro-lyase.	0
NZ_CP049918.1\|WP_010930616.1\|1918318_1919293_+\|TRAP-transporter-substrate-binding-protein	gnl\|CDD\|270320	cd13602, PBP2_TRAP_BpDctp6_7, Substrate-binding domain of a pyroglutamic acid binding DctP subfamily of the tripartite ATP-independent periplasmic transporters; contains the type 2 periplasmic binding protein fold. DctP6 and DctP7 groups of the TRAP transporters that involved in pyroglutamic acid transport. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	6.1715e-122
NZ_CP049918.1\|WP_010926712.1\|1950446_1951496_-\|TRAP-transporter-substrate-binding-protein	gnl\|CDD\|270320	cd13602, PBP2_TRAP_BpDctp6_7, Substrate-binding domain of a pyroglutamic acid binding DctP subfamily of the tripartite ATP-independent periplasmic transporters; contains the type 2 periplasmic binding protein fold. DctP6 and DctP7 groups of the TRAP transporters that involved in pyroglutamic acid transport. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	6.91168e-120
NZ_CP049918.1\|WP_010926704.1\|1921119_1922871_-\|filamentous-hemagglutinin-transporter-protein-FhaC	gnl\|CDD\|377148	pfam03865, ShlB, Haemolysin secretion/activation protein ShlB/FhaC/HecB. This family represents a group of sequences that are related to ShlB from Serratia marcescens. ShlB is an outer membrane protein pore involved in the Type Vb or Two-partner secretion system where it is functions to secrete and activate the haemolysin ShlA. The activation of ShlA occurs during secretion when ShlB imposes a conformational change in the inactive haemolysin to form the active protein.	4.10341e-92
NZ_CP049918.1\|WP_138142578.1\|1926658_1927393_-\|molecular-chaperone-FimB	gnl\|CDD\|225663	COG3121, FimC, P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion].	2.05728e-76
NZ_CP049918.1\|WP_003811089.1\|1919299_1919800_+\|TRAP-transporter-small-permease	gnl\|CDD\|377284	pfam04290, DctQ, Tripartite ATP-independent periplasmic transporters, DctQ component. The function of the members of this family is unknown, but DctQ homologs are invariably found in the tripartite ATP-independent periplasmic transporters.	1.01797e-16
NZ_CP049918.1\|WP_033447514.1\|1947694_1948381_-\|DUF2848-domain-containing-protein	gnl\|CDD\|371339	pfam11010, DUF2848, Protein of unknown function (DUF2848). This bacterial family of proteins has no known function.	3.13537e-91
NZ_CP049918.1\|WP_003811093.1\|1916756_1918055_+\|TRAP-transporter-large-permease-subunit	gnl\|CDD\|129868	TIGR00786, TRAP_transporter_permease_protein_SiaT, TRAP transporter, DctM subunit. The Tripartite ATP-independent Periplasmic Transporter (TRAP-T) Family (TC 2.A.56)- DctM subunit TRAP-T family permeases generally consist of three components, and these systems have so far been found in Gram-negative bacteria, Gram-postive bacteria and archaea. Only one member of the family has been both sequenced and functionally characterized. This system is the DctPQM system of Rhodobacter capsulatus (Forward et al., 1997). DctP is a periplasmic dicarboxylate (malate, fumarate, succinate) binding receptor that is biochemically well-characterized. DctQ is an integral cytoplasmic membrane protein with 4 putative transmembrane a-helical spanners (TMSs). DctM is a second integral cytoplasmic membrane protein with 12 putative TMSs. These proteins have been shown to be both necessary and sufficient for the proton motive force-dependent uptake of dicarboxylates into R. capsulatus. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	3.23324e-98
NZ_CP049918.1\|WP_033468462.1\|1949716_1950337_-\|TRAP-transporter-small-permease	gnl\|CDD\|377284	pfam04290, DctQ, Tripartite ATP-independent periplasmic transporters, DctQ component. The function of the members of this family is unknown, but DctQ homologs are invariably found in the tripartite ATP-independent periplasmic transporters.	1.11374e-16
NZ_CP049918.1\|WP_010926705.1\|1922863_1923961_-\|fimbrial-protein	gnl\|CDD\|226069	COG3539, FimA, P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion].	3.3674e-07
NZ_CP049918.1\|WP_165645822.1\|1919792_1921094_+\|TRAP-transporter-large-permease-subunit	gnl\|CDD\|129868	TIGR00786, TRAP_transporter_permease_protein_SiaT, TRAP transporter, DctM subunit. The Tripartite ATP-independent Periplasmic Transporter (TRAP-T) Family (TC 2.A.56)- DctM subunit TRAP-T family permeases generally consist of three components, and these systems have so far been found in Gram-negative bacteria, Gram-postive bacteria and archaea. Only one member of the family has been both sequenced and functionally characterized. This system is the DctPQM system of Rhodobacter capsulatus (Forward et al., 1997). DctP is a periplasmic dicarboxylate (malate, fumarate, succinate) binding receptor that is biochemically well-characterized. DctQ is an integral cytoplasmic membrane protein with 4 putative transmembrane a-helical spanners (TMSs). DctM is a second integral cytoplasmic membrane protein with 12 putative TMSs. These proteins have been shown to be both necessary and sufficient for the proton motive force-dependent uptake of dicarboxylates into R. capsulatus. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	2.26176e-125
NZ_CP049918.1\|WP_003811054.1\|1951838_1952747_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	8.89176e-42
NZ_CP049918.1\|WP_010930609.1\|1940022_1940652_+\|virulence-factors-two-component-system-response-regulator-BvgA	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	3.75971e-63
NZ_CP049918.1\|WP_003811061.1\|1948436_1949720_-\|TRAP-transporter-large-permease	gnl\|CDD\|224509	COG1593, DctQ, TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism].	8.16313e-87
NZ_CP049918.1\|WP_003811078.1\|1927642_1928248_-\|fimbrial-protein	gnl\|CDD\|339870	pfam16970, FimA, Type-1 fimbrial protein, A. FimA is a family of Gram-negative fimbrial component A proteins that form part of the pili. There are usually up to 1000 copies of this subunit in one pilus that form a helically wound rod onto which the tip fibrillum (FimF.FimG, FimH) is attached. Pilus subunits are translocated from the cytoplasm to the periplasm via the general secretory pathway SecYEG.	7.01167e-69
NZ_CP049918.1\|WP_003811072.1\|1940660_1944377_+\|virulence-factors-two-component-system-sensor-histidine-kinase-BvgS	gnl\|CDD\|182169	PRK09959, PRK09959, acid-sensing system histidine kinase EvgS.	1.19298e-146
NZ_CP049918.1\|WP_165645825.1\|1946284_1947634_-\|amidase	gnl\|CDD\|235921	PRK07056, PRK07056, amidase; Provisional.	0
NZ_CP049918.1\|WP_003811094.1\|1916272_1916764_+\|TRAP-transporter-small-permease	gnl\|CDD\|377284	pfam04290, DctQ, Tripartite ATP-independent periplasmic transporters, DctQ component. The function of the members of this family is unknown, but DctQ homologs are invariably found in the tripartite ATP-independent periplasmic transporters.	1.90947e-16
NZ_CP049918.1\|WP_165645823.1\|1923974_1926596_-\|fimbrial-biogenesis-outer-membrane-usher-protein	gnl\|CDD\|376353	pfam00577, Usher, Outer membrane usher protein. In Gram-negative bacteria the biogenesis of fimbriae (or pili) requires a two- component assembly and transport system which is composed of a periplasmic chaperone and an outer membrane protein which has been termed a molecular 'usher'. The usher protein is rather large (from 86 to 100 Kd) and seems to be mainly composed of membrane-spanning beta-sheets, a structure reminiscent of porins. Although the degree of sequence similarity of these proteins is not very high they share a number of characteristics. One of these is the presence of two pairs of cysteines, the first one located in the N-terminal part and the second at the C-terminal extremity that are probably involved in disulphide bonds. The best conserved region is located in the central part of these proteins.	0
NZ_CP049918.1\|WP_003811069.1\|1944423_1945299_-\|EAL-domain-containing-protein	gnl\|CDD\|376350	pfam00563, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.	1.53847e-49

>NZ_CP049918.1|WP_003811078.1|1927642_1928248_-|fimbrial-protein
MNLKFAGIALGLTACALTYQHQVFAADGTLVITGAITDTTCKINGAEPPTNIAVQLPTISRTALKDVGSTAGGTVFDVKLTECPQALNGQQVGLFFEPGGTVDYTSGNLFAYRADSQGVEQVPQTKADNVQFQLANLDGSAIHLGRNKGAQAAQTFLVSQTAGSSTYGTTLRYLARYIRSGAGSIVAGNLRSQVGFSVMYP
>NZ_CP049918.1|WP_138142578.1|1926658_1927393_-|molecular-chaperone-FimB
MARWRRRLGVAALGAAMLASLAPAARASLVITGTRVIYNAGSPETTVKMSNEGQAPALMQAWIDDGNAEAKPDEVQVPFFLTPPLARVDPGKGQTLRIFFNGYPDGKTLPSDRESVFWLNVLEVPPKATPEEGHGVLQLTIRSRLKLFYRPKGLPGNPLTAAADLTFKRKANGVLEVHNPTPYYVNLQKLEVGENGAHGSKTPWMLAPLSSDELRLKGTGAKSVQYWAIDDFGGVTPYQAAIAD
>NZ_CP049918.1|WP_165645823.1|1923974_1926596_-|fimbrial-biogenesis-outer-membrane-usher-protein
MKQIPLILAMSLAFAAAAKGESAPDMQAAVNFDSAMLWGGANGADLSRFNYSNALRPGNYIVDIYANNYPLIRQQVRFVAAQTSGQGLKTAPAVACFTYGQLEAMQVRLRALDPALVADLKSSGRCEVLGKLFPDSRESFDFGENRLEVSIPQAYTINRFRRDISPDEWDSGITAFRLGYQYNYADYIGGLRAGRRLDLNLYSGFNFKGWYLRNSSTLGWGQGRFTRRSQRTSLQTDIPSWRARLVFGDVFSSGEYFAPYSMRGMLVGSDTAMLPYSERLYRPTIRGVARTRANVKVYQAGVLVFQDAVPPGPFAIDDYSPASYGGDLRVVVTEANGAVQTFTVPYASAVRLILPGQTQWSFSAGRYRNYRNDGQDRPWVTQLTGRHGVADGVNLYGGLLIAQAYQAGLAGLSWNTPWGAMAADATLSRSQLSTTGNANGSSLRFSYSKTLSGTNTAIRLATLRYSSSGFWNFADAVNAGPAETNGRNGRFGLYSLLGRERPRGDFSVTLSQPLGGYGSLYVSALRRTYWGSSRVDQQTQLGYSTQVGRVGVNLDVSRTENRRSTEHQVMLNLSIPLYGATSSGVVTGSLARTGSAPVQQSVNYSGMSGERDQYTYGLGVQRAGTSAQYALNGSWSGTYGEVSGQLTHGRSYSQYQINGSGGLVAHAGGVTFGQYQAGTIGLIQAEAAAGAKVVNTRNAAVDRSGYGLVSLTPYSLNEVELSPQDLPLDVQLESTVEQVIPRAGAVVALRFPTRHDVAAMLVAEPGSEGALAFGTEVRDGAGKVVGVAGQGASALVRGVSASGTLEVTRADGSICRATYDLKSAGHAVHGLPRIALACAPQGGGERGARAAVQAVAQPAPISISGKDHEPDIR
>NZ_CP049918.1|WP_010926705.1|1922863_1923961_-|fimbrial-protein
MPARVISFCGAALAVWAGLAVQPAMAVDPPVDCGRALGLHFWSSTSLISDQTPDGTLIGKPVVGRSLLSKSCEVPDDIKDELSDKHDGEPVDIVLELGSSYKIRPQSYGHPGIVVDLPSGSTEETGIAIYIDFGSSPMQKVGERQWLYPQKGEVLFDALAINGDNAEVRYQAIKVGPLKRPRKLVLSQFPNLFTYKWVFMRGTSQERVLATGTISTDVATSTIDLKTCRYTSQTVSLPTIQRSALTGVGTTLGTTDFQMPFWCYGRPRVSVYMSAANTQTGVDGVALPATGQAAGMASGVGVQLINGKTQQPVKLGLQGKIALPEAQQTESATFSLPMKAQYYQTSTSTSAGKLSVTYAVTLNYD
>NZ_CP049918.1|WP_010926704.1|1921119_1922871_-|filamentous-hemagglutinin-transporter-protein-FhaC
MTDATNRFRPGLVVRALVRAGLLFAVAACAQAQLLPGARDLNRIDDRQRKEQLQRDIERALTRPPVELNPQSEAASPARKPDATSGHTVTVHAVDLDFGVEGRLFDPAPLVQDYLNRPLDNEQLFLLVKALSAALYDRGYATSIVTFVPPGVVDGVLKLKVEWGRIKGWLIDGKPLERTRDRMMVFSAMPGWQDKVLNVFDIDQAIYNINNGGKTGNITIVPADEYGYSYLDLQLQRRALPRVSLGMDNSGPGTPENGRYKYNASVTANDLLGLNDTLGLYIGNRYYRDAGHDAERNYDLMYSVPLGRTRLDLQTGYSTYRNLLKTRYGQYQSAGNSRSFGLKATRLLYRDTRSQFSVYGGLKLRQNKNYLAGTRLDVSSKHYSDVTVGMQYSTQRGANAYFGDLSFTRGVGINNGKYAAYDERGPQGNVSRLNGSLAWTRYMALADQPLQWTSQLGFQYSRQQLLNSYQITVGDEYTVRGYNLRTSQSGDSGAYLSNTLTVPVQFSLFGKQASMAPFAGVDVGALKSNHPDARTIRMAGLAAGVRFDLPYARLSFTYSKPVGAQPGGAPRAPVWYINAGLSF
>NZ_CP049918.1|WP_165645822.1|1919792_1921094_+|TRAP-transporter-large-permease-subunit
MNEILIVTLLVVSIFALLGCGVWVGLTLAGTAWIGMEVLSSRPAGDAMAVTIWGASSSWTLTALPLFLWMGEILFRTRLSEDLFKGLAPWLNRLPGRLLHTNVIGCAIFAAVSGSSAATCATVGKMTIPELTRRGYPEDKILGTLSGAGTLGLLIPPSIIMIVYGVAADVSIAKLFIAGIFPGLLLALLFMGYIAWWAIRHPGAVPAADPGISLMQKLKQSRHLIPVLLLIGAVLGSIYTGIATATEAAAVGVVGALILSALQGSLTRASFMTSLLGATRLYCMIALILAGAQFLTLAMGYIGLPRALAEWIGGLGLSQFGLIMALMVFFIVLGCFLDGISIVVLTMGVLLPTVQAAGIDLIWFGIFIVFVVEMAQITPPVGFNLFVLAGMSGRELPYIARASLPMFFLMIVAVLLLYYLPGIATWLPQHMTL
>NZ_CP049918.1|WP_003811089.1|1919299_1919800_+|TRAP-transporter-small-permease
MRRFLDRLYGAAGLLAGLCTIGVLVSVLAAIIARQVGLNIPGTDAYAGYFMAAAGFLALASTFKHGEHIRVTLLLNALSAPGHRRLDIFALCVGAILAAAFAWFSVKLAHDSWLFNDISTANDATPLWIPQLTMAAGTILFFIALLDELVRRVRGQGFAKSQQIHE
>NZ_CP049918.1|WP_010930616.1|1918318_1919293_+|TRAP-transporter-substrate-binding-protein
MYKKLSLLAGTIVLAFGAGAQAQTKWDLPTAYPASNLHVENLTQFVKDVDSLSGGKLKITLHNNASLYKAPEIKRAVQGNQAQIGEILLTNFANEDPVYELDGLPFLATGYDASFKLYQAQKPFLEKKLASQGMMLLYSVAWPPQGIFANRDIKQVSDMKGLKWRAYSPVTAKIAELVGAQPVTVQQAELAQAMATGVIDSYMSSGSTGFDTKTYEYIKKFYDTEAWLPKNAVLVNKKAFDALDPATQQALKKAGAQAEERGWKLSQEKNSWYKEQLAKNGMAIIAPTAELKSGLTEVGKRMLDDWLKKAGADGQAMIDAYRKQ
>NZ_CP049918.1|WP_003811093.1|1916756_1918055_+|TRAP-transporter-large-permease-subunit
MGELAQSLVLIASLLLLLAAGVWVSLALVASGLVALLLFTDAPAGIIFATKSWDASANWALTALPLFIWMGEILYRTRLAEDMFSGLGPWVRRLPGRLVHVNVLGCGIFAAVSGSSAATAATIGRISLPELKARGYDDGLAIGSLAGAGTLGLLIPPSIVMIVYGVAAQVSLIKLFIAGILPGLLLMALFSGYIGVWSLRNPARVPPREPAVPWLTMLARLRLLLPVVALIAGVIGSIYAGIATATEAATIGVIGALAIAAWGKSLNRRSFIDSLMGATRTSCMISFILLGAAYLTSAMSFTGLPANLAEWISSLGLSQYGLIAVLTVFFILMGAFLDGISIVVLTTAVLMPAIQAADIDPIWFGIYLILVVEMAQITPPVGFNLFVIQGITGRNLFELVRMAFPFFLLLVLATAIITIFPAIVTALPLAMR
>NZ_CP049918.1|WP_003811094.1|1916272_1916764_+|TRAP-transporter-small-permease
MPILDRIAVASGAVAALFLALIGAIVAAQIASRLLGMQIPAADDFAAWSMAASVFLALPYAMLRGDHIRVTLLLQFLPKTAHRPYELAATALGLALSAWAAWQAAGFVHESFAYDEVAQGMLRVPLWIPQICMPIGLALLTLMLARRLAMVARGRQPEETAHG
>NZ_CP049918.1|WP_010930609.1|1940022_1940652_+|virulence-factors-two-component-system-response-regulator-BvgA
MYNKVLIIDDHPVLRFAVRVLMEKEGFEVIGETDNGIDGLKIAREKIPNLVVLDIGIPKLDGLEVIARLQSLGLPLRVLVLTGQPPSLFARRCLNSGAAGFVCKHENLHEVINAAKAVMAGYTYFPSTTLSEMRMGDNAKSDSTLISVLSNRELTVLQLLAQGMSNKDIADSMFLSNKTVSTYKTRLLQKLNATSLVELIDLAKRNNLA
>NZ_CP049918.1|WP_003811072.1|1940660_1944377_+|virulence-factors-two-component-system-sensor-histidine-kinase-BvgS
MPAPHRLYPRSLICLAQALLAWALLAWAPAQASQELTLVGKAAVPDVEITLDGDDWRWLARKRVLTLGVYAPDIPPFDVTYDERYEGLTADYMAIIAHNLGVQAKVLRYPTREQAVGALESGQIDLIGTVNGIEGRLQSLRLSVPYAADHPVLVMPIGARRAPPADLAGQRLAVDANYLPRETLQQAYPQATLHYFPSSEQALAAVAYGQADVFIGDALTTSHLVSQSYFNDVRVVAPAQIVTGGESFGVRADNTRLLRVVNAVLEAIPASERRSLIYRWGLGSSISLDFARPAYSAREQQWMANHPVVKVAVLNLFAPFTLFRTDEQFGGISAAVLQLLQLRTGLDFQIIGVDTVEELIAKLRSGEADMAGALFVNAARESVLSFSRPYVRNGLVIVTRQDPAAPADADHLDGRTIAMVRNSAAIPLLQQRYPQAKVVTADNPTEAMLLVADGQADAVVQTQISASYYVNRYFAGKLRIASALDLPPAEIALATARGQTELISILNKALYSISNDELASIVSRWRGSDGDPRTWYAYRNEIYLLIGLGLLSALLFLSWIVYLRRQIRQRKRAERALNDQLEFMRVLIDGTPNPIYVRDKEGRMLLCNDAYLDTFGVTADAVLGKTIPEANVVGDPALAREMHEFLLTRMAAEREPRFEDRDVTLHGRTRHVYQWTVPYGDSLGELKGIIGGWIDITERAELLRELHDAKESADAANRAKTTFLATMSHEIRTPMNAIIGMLELALLRPADQEPDRQSIQVAYDSARSLLELIGDILDIAKIEAGKFDLAPVRTALRALPEGAIRVFDGLARQKGIELVLKTDIVGVDDVLIDPLRMKQVLSNLVGNAIKFTTEGQVVLTVTARPDGEAAHVQFSVSDTGCGISEADQRQLFKPFSQVGGSAEAGPAPGTGLGLSISRRLVELMGGTLVMRSAPGVGTTVSVDLRLTMVEKSAQATPPAAAAQATPSKPQVSLRVLVVDDHKPNLMLLRQQLDYLGQRVVAADSGEAALALWHEHAFDVVITDCNMPGINGYELARRIRAAEAAPGYGRTRCILFGFTASAQMDEAQRCRAAGMDDCLFKPIGVDALRQRLNEAAARAALPTPPSPQAAAPATHDATPAAFSAESILALTQNDEALIRQLLEEVIRTNRADVDQLQKLHQQADWPKVSDMAHRLAGGARVVDAKAMIDTALALEKKAQGQAGPSPEIDGMVRTLAAQSAALETQLRAWLEQRPHQGQP
>NZ_CP049918.1|WP_003811069.1|1944423_1945299_-|EAL-domain-containing-protein
MIHWTNSARSSFEASLSPSRRTLRARLAPVEGPTVAELRAALKRDEFIPAFQPVVDAGTGSLFGVATTIQWAHRHWGLVPEHCYMAALVRDNLHIALAQQLLAQVFDLAAAMRRGNRHVGLFIQPEPICLMSRSYSDDVLRNLDHRGLPPFALTLAVSPSLLQSPYGQQSLHSLRRLHRAGCNLVLTVSTFDAESPPHLDALEICGIALMPELMYALRQGGRAGEACRAIAQQASAQRIPVMATGVVDEAMAQAADLLPCRYLLGDHVAPPMTGQRFLYWYYRREMPPNYP
>NZ_CP049918.1|WP_010930607.1|1945432_1946227_-|putative-hydro-lyase
MTILSLAGAGHQARLDARGGMLTGPTANLAPGHVQANLAILPQAVAGDFLRFCQRNPKPCPLLAVSEPGDPSLPELGLDIDIRTDVPRYRVWRDGKLVDEPLDVRGLWRDDLVAFLIGCSFSFEEAMLENGLPVRHIEQGCNVPMYRTNIATHPAGPFSGPLVVSMRPLKAADAIRAIQVTSRFPSVHGAPVHLGDPALIGIADLGRPDYGDAVEIRAGEIPVFWACGVTPQSVVAAVRPEFCITHAPGHMLVTDLLNSRLAAF
>NZ_CP049918.1|WP_165645825.1|1946284_1947634_-|amidase
MLPTLTQQSLALQEGRDTSSGLTQAALARAADPAREGARVFTRVYAEQARAEARAADALRAAGVTRSAIDGLPISIKDLFDVAGETTMAGSVARQGEPAAVRDAVVVRRLRAAGAVIVGRTNMTEFAYSGLGLNPHYGTPRNPWDRATGRIPGGSSSGAAVSVTDGMASGAIGSDTGGSVRIPAALCGLAGFKPSAQRVSMQGVLPLSANLDSIGPLAPSVRCCATLDAILAGGDDADIPAPAALRGLRLAVPTTLALDGLDAHVSATFAATLAKLAEAGACIDEIAVPEFAQLADINSKGGFTAAEAWAWHRDLIERAADRYDPRVVARIRRGADMSAADYIDLLAARQAWRARVEARIAGYDALVLPTVPVVAPAIADLEASDALFGSTNLLILRNPTLINFLDGSALSLPCHEAGTAPVGLMVAAANGSDRRVLAIGMAIEDLLGG
>NZ_CP049918.1|WP_033447514.1|1947694_1948381_-|DUF2848-domain-containing-protein
MKIAFQVQADGATRTVETEIRNLVVAGWAGRDRAAIEHHIEELAELGVPRPSSVPLYYRIAENQLSQAGRVQAVGPDSSGEAETFVFSVGGELYVSLASDHTDRKLEAHSVALSKQVCVKPVASDAWRHADVAEYWDELVLRSYIVENGAEVLYQEGTLASLRTPQDLIAGYTQGQASLPEGTGMTCGTVAAIGGIRASTTFIMELHDPRRQRTLRHRYDVEVLPEIA
>NZ_CP049918.1|WP_003811061.1|1948436_1949720_-|TRAP-transporter-large-permease
MIATALILLLVLIGISIPVGAALGVLGLILDPLYSMLPLTRAIGEVTWSANNEFLLVAIPLFIMLGEVLLRAGFAERMYAAMSLWLSWLPGGLMHANIGASTLFSATSGSSVATAATVGTVAIPQIKKYGYNEPLFLGSLAAGGTLGILIPPSINLVIYGVLTNSSVPKLYLAGIIPGFAMAALFMMTVVVACVAKPSWGGHRIQASWAQRIASLVHLGPPMAIFFLVVGSIYAGLATPTEAAALGVLGALILAAWFRRLTWTMLREAIEGTMRSTAMIMLIVLAASFLNFVMSATGLTDALVQSITGLGLSPGWMLLIVVIFYLVLGCFMETLSMMITTIPIVAPIMIALGYDPIWLGILIIVLVEAALITPPVGLNLFVVQSLRKSGSMTAVINGALPFVLAMFVMLALLAFFPDLALWLPRVFG
>NZ_CP049918.1|WP_033468462.1|1949716_1950337_-|TRAP-transporter-small-permease
MTRSEHFRALGGLLRRAESLSRLAVWVGGALTIASVLLISFDVLARKFFGFTTGGADELSSYAFAISTSWALAFATLQRANVRVDVVYQYLPVRVSAVLDWIALVALGVFMVFMTYYAYEVVQTSWAQKSAANTPLATPLWIPQGLWALGLAWMCVTVALMLVRASAALVTGDLDLVKEICGVRSAQEEADEEAAAGERMVKGASA
>NZ_CP049918.1|WP_010926712.1|1950446_1951496_-|TRAP-transporter-substrate-binding-protein
MKKPFVFAAAFAVAALTGAVHAQDLPKTKVKVVGGLSNLTAYNDYEKPFWTKTVPELSKGQVTADIKGFNEMGLKGPEILRLMSQGVIEFGTATLAYFASDNPINEAIDLAGLAPDVKTARQVTDAFEPVYAKLYGEGANVKLLGISTYPAQVLFCNAEITGLADIKGKKVRTSSRTTAEFVEALGGSSVTMAFGEVVPALQNKVVDCAITGSLSGYSAKWYEVSTHLYALPINWNQQIHAVNQKAWDKLDPKVRTFLQDNIKNLVDQIWDAAARQTQEGYDCNTGAAACPYPVKGKMVLVQPTDADRALLKKVTEEAVLPKWAARCSAQCVSDFNATIGKTLGLVAKK
>NZ_CP049918.1|WP_003811054.1|1951838_1952747_-|LysR-family-transcriptional-regulator
MIDLKHIETFFWVSTLGSFRAAAEKLNTTQPAISQRIASLEADLGVRLFERDARGVSLTGKGQELLSHAERMLQMRHDLMQAAREQNVMSGTVRIGVAETIVQTWLPALIEHVHAAYPALVLQIEVDTTHVLRGQLMARQIDVAFLMGPILEARMENIPLCAYPLAWVASPLLELGPEPLTLERIGTLPVITYPSSSEPYRQVRDMLTRAGVAAPRMYGSASLAMVVRMTKDGIGTSVIAPVFLDEELARGELRLLNVQADPLPDLSFTASWVQGPDSHAARAIALLAQRTAAEHGGAIGAG

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Crispr_ID: NZ_CP049918_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049918_4

2168212-2168308

Orphan

Consensus_repeat	Method
GTGCCTGTCCCGGCGGGGACAGGCACCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049918_4

>merge|NZ_CP049918|4|2168212-2168308|CRISPRCasFinder
GTGCCTGTCCCGGCGGGGACAGGCACCCAGCCGCAGATGTCAGTCCCCATGCCGCTGGCGCATGACGGCGTGCCTGTCCCGGCGGGGACAGGCACCC

>NZ_CP049918|4|4|2168212-2168308|CRISPRCasFinder
GTGCCTGTCCCGGCGGGGACAGGCACCC	AGCCGCAGATGTCAGTCCCCATGCCGCTGGCGCATGACGGC
GTGCCTGTCCCGGCGGGGACAGGCACCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049918.1\|WP_010926763.1\|2163740_2165315_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173867
NZ_CP049918.1\|WP_003810637.1\|2162743_2163688_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_CP049918.1\|WP_033447328.1\|2174660_2175716_-\|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA	unknown	unknown	gnl\|CDD\|273137
NZ_CP049918.1\|WP_003810615.1\|2172804_2173677_-\|MOSC-domain-containing-protein	unknown	unknown	gnl\|CDD\|225758
NZ_CP049918.1\|WP_003810630.1\|2165714_2167091_-\|DUF1446-domain-containing-protein	unknown	unknown	gnl\|CDD\|377804
NZ_CP049918.1\|WP_165645841.1\|2156412_2157990_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274177
NZ_CP049918.1\|WP_003810621.1\|2169749_2171006_-\|D-amino-acid-dehydrogenase	unknown	unknown	gnl\|CDD\|234819
NZ_CP049918.1\|WP_003810609.1\|2175712_2176930_-\|four-carbon-acid-sugar-kinase-family-protein	unknown	unknown	gnl\|CDD\|377757
NZ_CP049918.1\|WP_003810643.1\|2158916_2160272_-\|amidase	unknown	unknown	gnl\|CDD\|223232
NZ_CP049918.1\|WP_003810617.1\|2172305_2172674_-\|aspartate-1-decarboxylase	unknown	unknown	gnl\|CDD\|180090
NZ_CP049918.1\|WP_003810603.1\|2178202_2179129_-\|ectoine-hydroxylase	unknown	unknown	gnl\|CDD\|131461
NZ_CP049918.1\|WP_033447322.1\|2165362_2165728_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049918.1\|WP_165645843.1\|2176930_2177953_-\|2-keto-3-deoxygluconate-permease	unknown	unknown	gnl\|CDD\|235384
NZ_CP049918.1\|WP_010926765.1\|2173753_2174656_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NZ_CP049918.1\|WP_165645842.1\|2157986_2158739_-\|TrbG/VirB9-family-P-type-conjugative-transfer-protein	unknown	unknown	gnl\|CDD\|132874
NZ_CP049918.1\|WP_003810639.1\|2161895_2162726_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_CP049918.1\|WP_003810641.1\|2160268_2161903_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224048
NZ_CP049918.1\|WP_003810623.1\|2168407_2169745_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|182876
NZ_CP049918.1\|WP_003810619.1\|2171201_2172248_-\|CDP-6-deoxy-delta-3,4-glucoseen-reductase	unknown	unknown	gnl\|CDD\|181058
NZ_CP049918.1\|WP_003810628.1\|2167187_2168138_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176131

Protein	Function_ID	Function_description	E-value
NZ_CP049918.1\|WP_010926763.1\|2163740_2165315_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173867	cd08502, PBP2_NikA_DppA_OppA_like_16, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NZ_CP049918.1\|WP_003810637.1\|2162743_2163688_-\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.42336e-123
NZ_CP049918.1\|WP_033447328.1\|2174660_2175716_-\|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA	gnl\|CDD\|273137	TIGR00557, pdxA, 4-hydroxythreonine-4-phosphate dehydrogenase. This model represents PdxA, an NAD+-dependent 4-hydroxythreonine 4-phosphate dehydrogenase (EC 1.1.1.262) active in pyridoxal phosphate biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridoxine].	5.6385e-117
NZ_CP049918.1\|WP_003810615.1\|2172804_2173677_-\|MOSC-domain-containing-protein	gnl\|CDD\|225758	COG3217, COG3217, Uncharacterized Fe-S protein [General function prediction only].	6.93466e-61
NZ_CP049918.1\|WP_003810630.1\|2165714_2167091_-\|DUF1446-domain-containing-protein	gnl\|CDD\|377804	pfam07287, AtuA, Acyclic terpene utilisation family protein AtuA. This family consists of several bacterial and plant proteins of around 400 residues in length. One member of this family has been characterized in Pseudomonas citronellolis as AtuA, a member of a gene cluster that is essential for the acyclic terpene utilisation (Atu) pathway.	1.98672e-160
NZ_CP049918.1\|WP_165645841.1\|2156412_2157990_-\|hypothetical-protein	gnl\|CDD\|274177	TIGR02520, putative_Type_IV_pilus_protein, type IVB pilus formation outer membrane protein, R64 PilN family. Several related protein families encode outer membrane pore proteins for type II secretion, type III secretion, and type IV pilus formation. This protein family appears to encode a secretin for pilus formation, although it is quite different from PilQ. Members include the PilN lipoprotein of the plasmid R64 thin pilus, a type IV pilus. Scoring between the trusted and noise cutoffs are examples of bundle-forming pilus B (bfpB). [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking].	7.89923e-54
NZ_CP049918.1\|WP_003810621.1\|2169749_2171006_-\|D-amino-acid-dehydrogenase	gnl\|CDD\|234819	PRK00711, PRK00711, D-amino acid dehydrogenase.	0
NZ_CP049918.1\|WP_003810609.1\|2175712_2176930_-\|four-carbon-acid-sugar-kinase-family-protein	gnl\|CDD\|377757	pfam07005, DUF1537, Putative sugar-binding N-terminal domain. This conserved region is found in proteins of unknown function in a range of Proteobacteria as well as the Gram-positive Oceanobacillus iheyensis. Structural analysis of the whole protein indicates the N- and C-termini interacting to produce an interacting surface into which a threonate-ADPcomplex is bound, suggesting that a sugar binding site is on the N-terminal domain here, and a nucleotide binding site is in the C-terminal domain (manuscript in preparation). There is a critical motif, DDXTG, at approximately residues 22-25.	1.20657e-54
NZ_CP049918.1\|WP_003810643.1\|2158916_2160272_-\|amidase	gnl\|CDD\|223232	COG0154, GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis].	6.98538e-115
NZ_CP049918.1\|WP_003810617.1\|2172305_2172674_-\|aspartate-1-decarboxylase	gnl\|CDD\|180090	PRK05449, PRK05449, aspartate alpha-decarboxylase; Provisional.	1.84176e-73
NZ_CP049918.1\|WP_003810603.1\|2178202_2179129_-\|ectoine-hydroxylase	gnl\|CDD\|131461	TIGR02408, putative_L-proline_4-hydroxylase, ectoine hydroxylase. Both ectoine and hydroxyectoine are compatible solvents that serve as protectants against osmotic and thermal stresses. A number of genomes synthesize ectoine. This enzyme allows conversion of ectoine to hydroxyectoine, which may be more effective for some purposes, and is found in a subset of ectoine-producing organisms.	0
NZ_CP049918.1\|WP_165645843.1\|2176930_2177953_-\|2-keto-3-deoxygluconate-permease	gnl\|CDD\|235384	PRK05274, PRK05274, 2-keto-3-deoxygluconate permease; Provisional.	2.75895e-131
NZ_CP049918.1\|WP_010926765.1\|2173753_2174656_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	2.15288e-54
NZ_CP049918.1\|WP_165645842.1\|2157986_2158739_-\|TrbG/VirB9-family-P-type-conjugative-transfer-protein	gnl\|CDD\|132874	cd06911, VirB9_CagX_TrbG, VirB9/CagX/TrbG, a component of the type IV secretion system. VirB9 is a component of the type IV secretion system, which is employed by pathogenic bacteria to export virulence proteins directly from the bacterial cytoplasm into the host cell. Unlike the more common type III secretion system, type IV systems evolved from the conjugative apparatus, which is used to transfer DNA between cells. VirB9 was initially identified as an essential virulence gene on the Agrobacterium tumefaciens Ti plasmid. In the pilin-like conjugative structure, VirB9 appears to form a stabilizing complex in the outer membrane, by interacting with the lipoprotein VirB7. The heterodimer has been shown to stabilize other components of the type IV system. This alignment model spans the C-terminal domain of VirB9. CagX is a component of the Helicobacter pylori cag PAI-encoded type IV secretion system. Some other members of this family are involved in conjugal transfer to T-DNA of plant cells.	1.24067e-29
NZ_CP049918.1\|WP_003810639.1\|2161895_2162726_-\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.14667e-85
NZ_CP049918.1\|WP_003810641.1\|2160268_2161903_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	0
NZ_CP049918.1\|WP_003810623.1\|2168407_2169745_-\|extracellular-solute-binding-protein	gnl\|CDD\|182876	PRK10974, PRK10974, sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB.	1.31172e-74
NZ_CP049918.1\|WP_003810619.1\|2171201_2172248_-\|CDP-6-deoxy-delta-3,4-glucoseen-reductase	gnl\|CDD\|181058	PRK07609, PRK07609, CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated.	0
NZ_CP049918.1\|WP_003810628.1\|2167187_2168138_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176131	cd08440, PBP2_LTTR_like_4, TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.58441e-67

>NZ_CP049918.1|WP_003810628.1|2167187_2168138_+|LysR-family-transcriptional-regulator
MRPQADLSTRQLRAFVMLADLRHFTKAAQACHLSQPAFSALIQSLEATLAMQLFDRSTRRVVLTQEGELFEPLARRLLADLGHAMTHIASFVELRRGRVHVAALPSLAAGWLPKVLHEFHAEHPDIELMLSDVLSDECIELVRSGQADFALASRGIRASDPAVLHARELCSDTFHLICRKDHPLAREPRLTLKHLAPWPFIHLTRNSSVRQTVEAALRPQVAKTILEVAQLATVAGMIEAGLGISVVPTFTLYQFERPGLLIRPISLPGLTRQIYIVRRQEERLSIAAQALYDLVVAKLGTPAAAKPRRRRTEKGR
>NZ_CP049918.1|WP_003810630.1|2165714_2167091_-|DUF1446-domain-containing-protein
MRSLPSLLIGCAAGFSGDRVDAAGPVVDTLIARLGGVPANGRAFLIFETLAERTLALAQLRKRADAQAGYEPLLEDMLGPVLARCLAHGIRIVSNFGAANPEGAARHILRMAARLGLRKPRIAVVKGDDVSGAQHAGMLAEYLGEQYDPSSIVSANAYLGSEQIRDALDHGAEIVVCGRVADPSLTVGPAMSYFGWQADDWDRIGRATMAGHLLECGAQVCGGYYADPGYKDVPGLEQVGFPVAEIDEDGHCIIGKSDGTGGLVDEATVIEQLLYEVHDPAGYLTPDVVADISQAEVRRVADNQVRLTGVRGHPRPAAYKVNVCLEGGWLAEGEISYAGPRAEARARLAAEVVCKRLADLRIRTDLIGHVSIFGDDAGRLLAGAPAGDGEDVRLRLAAHAVTRQDAMRLTREVTALYCCGPAGGGGVRTTLTPRLDMVSCLLPRDLVRAGFEMVDADV
>NZ_CP049918.1|WP_033447322.1|2165362_2165728_-|hypothetical-protein
MPMSDVLVPLFRVAHARTGDKGDRSNISVIAWDRALYPLLVEQLTPEVVLAQFAHRRPAGAQRYLLPKLGAMNFVLDAVLDGGVNGALNLDAHGKALSYLILKTEIAVPSDLVCRLAGSPG
>NZ_CP049918.1|WP_010926763.1|2163740_2165315_-|ABC-transporter-substrate-binding-protein
MRYLKSTYAAVLLAIGTAVPHATTLAQEVKVAAEAPLRLLDPVGTTAYITRNHAYMVYDTLFALDAQLKPQPQMVSTWSVSPDKLVYRFTLRDGLKFHDGSPVTAADCVASIKRWAQRDLTGLRMMAAAKEITAKDDKTFEIVLEQPFGAVIEGLSKASSLPAFIMPKRIADAPASQAITEVIGSGPFRFVASEYRPGLQVVYERNTDYVPRSEPPSGLAGGKVVNVDRVVWLSLPDIQTEANALAKGEVDYVQTVYPDVVQTLQASKDVVIQKLASTTTPTLRLNWLQPPFNNQKVRQALLHAVSQRDYMDAQVGDPKAYRVCWAMFGCDSPLASTAGVVSQDDEADLNAAKALLKESGYKNEKAVVLHATDYPPTSAIAPFTAQILRSIGMKAEVQSMDWATFLTRRGKQDPVEKGGWSVAYGSWNTLDLMSPIANLNLDGRGKEGYAGWTESAEMESLRTQYAQATEPASRQQIAAKIQQLAYDQVFYIPLGTYSNYAARRSNVTPLLDAPVTVFWGISKN
>NZ_CP049918.1|WP_003810637.1|2162743_2163688_-|ABC-transporter-permease
MQILRLLFLRLASAIPVVLVVVTVVFLLVRLTGDPATILAGDMASPEVVASVRADLGLDRPLLGQYAQWLWDLLQGNLGTSIVTKQPVATLIGERLESTLVLSLSALVVTVLLAVPLGVLAAWRHNTLVDRVVMIYAVIGFSLPSFVVGYLLILMFSVWLGWLPVQGYVSITDDIWLAAQHLVLPTLALAIFYMSLISRVTRASVLEVLNEDFVRTAKAKGVPPLRILSQHVLRNAAIPIVTVIGIGLAFLISGVVITESVFNLPGLGRLTIDAVLSRDYPVVQGVILFFACVYILVNLLIDMLYVVIDPRIRY
>NZ_CP049918.1|WP_003810639.1|2161895_2162726_-|ABC-transporter-permease
MTSILRHNRLALLGGGVLLLMVAISVAASWIASMDPAMMQPRMRLTPPGEAFLLGTDALGRDVYSRVVHGSRMSLAIGALVVVITIAIGTLIGLVAGASRIMDRVLMRIMDGVMAIPGILLAVALVSLFGASLASVVIAIAVPEIPRVVRLVRSVVLSVREEPYVEAAVGLGVPYPKVVWRHILPNCFAPLIVQASYVFAAAILLEAVLGFLGVGFPPEIPTFGNILAEARPVFQRAPWATVAPGLLLAVTVLAVNLLGDGLRDSLDPKLARRAND
>NZ_CP049918.1|WP_003810641.1|2160268_2161903_-|ABC-transporter-ATP-binding-protein
MIENTPKQRVLEVSGLAIRAGARTLVQDVTLSLAQGEILCLVGESGSGKSLTASAVMGLLPGNLGVSAGSIRLDGEDLTAASPARMQALRGDRMAMVFQEPMTSLNPLMRVGRQIAEVLQVHRPDLGAGQVRARVLELMGDVHLPTPEALMDAFPHQLSGGQRQRIMIAMALALEPALIIADEPTTALDVTTQAQVLKLFRQLLAKHSSAVLFITHDFDVVRDIADHVAVMQLGRIVEQGPAGQVLDAPRHDYTRKLLAAVPSGVPKTQQNASSDELLSVSGLNLVYESRGLLGPARRTHAVADVGFTLKKGETLGVVGESGSGKSTLGRCITRAHAPTSGRIVFDGVDIAGLSGKALRAVRRRVQMVFQDPYRSLNPRRRILHALIEGPIESGVDRKAACARAAELMALVGLPADGLQRYPHQFSGGQRQRICIARALAMEPDLIVADEAVSALDVSVQAQVLELFEDLQKRLGFAMIFITHDLRVAAQVCDRIGVMQKGRLLELGPVRQVIHAPQHPYTRHLFDSLPGRVGQAAEPAMELQA
>NZ_CP049918.1|WP_003810643.1|2158916_2160272_-|amidase
MTSTDQHIARAGVAELARGIARGAFTPAEVTDVFLRRIQDLNPAIGAFVAVYEDEARHAARQATQALAQGQRLSPLHGIPFAVKDIVDVAGRFTTYGSRTGAGRQAGATAEYVRALLDAGMILLGKTHTVEFAFGGWGTNQRMGTPRNPLRADVPCATGGSSSGSGAAVGAQMVPFAVGTDTGGSIRIPSAFCGLTGMRPSMGRHSGAGVMSLSHTLDTIGPLARTVEDVQMLDDLLTGKTATDTAQPGSQAVARVRDARIGVLGAQWLGAIEPEVAHAYAQSLRAFEAMGATLVELALPFDREAFAQLTSTLIACEGLQFAGKYVHDPLSGMDEDVRARFLVGDRYDAAAYAELLGRRSAMIDTFTQAMAGVKALLMPTTPCVAQPLAGLEQSPYNPAVYTRMPAWLGCCALAVPNGSGAHGLPTSLQIVGLPESDRLVMSLGRAYQEYA
>NZ_CP049918.1|WP_165645842.1|2157986_2158739_-|TrbG/VirB9-family-P-type-conjugative-transfer-protein
MVRSLSIVCLLAVLQACAGPRPAAVAAAWDEAPAGQYRFDWQLSGDPAVAPLQVFDDARRIWLQFAPSQPIPAIFAHGAGGERPVPYLRRDPYIVVDGAWPALSLRGGRYVARIQRSGAPIPAGAPVVRAEGPAPVPATPSAVAPAEAAPPAPRFRAAPPDLTLRAVLARWARAAGWTFEAEHWALDVDIPLAGKAELPGDFKTAVRALLAATELSERPAQPCFYANRVLRVVPLAQACDRTRAAAPGLT
>NZ_CP049918.1|WP_165645841.1|2156412_2157990_-|hypothetical-protein
MKARRLAMAGLSLALGGCSLSQQMQAMRDAATSLRARLLEGQQAVGRAGERPAREAAQDVARPWLAGRAQPLAREVLLPPALRADVDTTLLFAGKATLPVLAERLHRATGIAVRVHPDALLPRAAFLPRLAGPAELAAEPPAQAELRAGPRPLADTLDALAAQLYVHWRYHRGAIEFYRTETRVFDVRTLALAASAQARLGRAGSGETGSFDHASSTVLSADAGKALQAVRDRVAAFLTRAGVIAEIEAGGSTLAVTDTPEALARIEKYLQGENRALTRRVRLVFEELTVRTTATAEGGIDWQAVYASARAAASYAMPGGAGAAGALGARVLAGPWRDARALIAALSTMGAVLRHRSIPMLTLNRRAVTHAVRTTFSYVDQVQRLSPTAAAPGGRDAVPGLAVQQKRETVGTFLTLLPEARDDGRILLSISYDNTIAQPLRTLTFGEGGQQVSLQQIAIDGSGIVQQVELLPGQPVILSGFDHSEDQYERHRLFPDAPLAAGGHDRTARERVTTVVMVTAQIDEG
>NZ_CP049918.1|WP_003810623.1|2168407_2169745_-|extracellular-solute-binding-protein
MKKLQMTGFARAMRASRRACVLGLAMAAMGVAQAADSVEIQVWHTLSGPNKAEFEKLAKQFNKEQGDVVVKLRDFGNQDDLKKEAVSAVKSKKGPNLVQLADNHSPEVVAEHKSILPLHQLLAKYPVKDLNWFLPSTTSFTRDGKGRLLAFPWMAEVPVMFYNTAYYKKAGLDPNKPARTWADLQAELLKLRDVANIDCPYATSDQVTVHLENLAPVNNQLYATLNNGLDVAKKGSPSMQFDTLYMRHVSLMVSWKRSLLLTAYSDDNKSDQLFAKGECAVLTTSSSALGQFLNTRSLSFGVAPLPYYDQVTKTGGRPFVSGSALWAMEGHPQAEEKATAKFLAWLSKPVIAAEWHQRTGYLPLTEAAFRASDVSFYNKVPGAQQLVELMRNPPAATSRGFRIANYERIEPVLNTQLTAAFDGKTPPVAALNNAASQARSLAAQR
>NZ_CP049918.1|WP_003810621.1|2169749_2171006_-|D-amino-acid-dehydrogenase
MKVAVLGSGIIGVSSAWWLSQAGHDVVVVDRCTGAAQETSLANGAQISVSYAEPWANPQAPFKLLKWMFQDDAPLLFRPQLDWRQWQWGLAFLRECLPSRLAPNIRAMVRMAEYSRATLQGMRAELGIQYDHLERGILNFYRDQREFETSQRAAGLMRDFGVERRVINADEVVAIEPALAPHRQTIVGGDYTPEDESGDVHLFAAALARRCEAAGVEFRFSTRVTRLLGEGGRVQGVELIEPDGRYGRLDADAFVVAMGSFSAQLVRPLGVPCMVYPAKGYSATFPVRPGALAPVVSLTDSSHKVVFSRLGERLRMAGTAELSGYSRGLNTGRCEAMTRLARELFPDALDFERVSYWSGLRPSTPSNVPLIGRTSVSNLYLNTGHGTLGWTMGVGSGRALADLLSGRRPEPEFPFLGL
>NZ_CP049918.1|WP_003810619.1|2171201_2172248_-|CDP-6-deoxy-delta-3,4-glucoseen-reductase
MSFQVTIEPSKHQFQAEAGQTVLDAALAAGIVLPYSCRTGACSTCKGKVVAGEVDAGPYPAQILSPEDLAQGYTLFCQAKPQSDLVVESTEVRLASDIQIRKLPSRVQTIERVAPDVAVLKLQLPASEQFRYYAGQYIEVILKDGKRRSYSMAGAPHTGSPLELHIRHMPGGLFTDHVFGAGDTQMKEREILRLEGPFGSFFLREDSDKPIVLLASGTGFAPVKAIVEHMIHNQIQRPAVLYWGGRRPRDLYHDALAQSWAGSLPGFRYVPVVSDALDEDGWSGRTGYVHEAVMQDLSDLSGYEVYACGTPLMVDAARREFSAQCGLPAEAFYADAFTSEADLAKATP
>NZ_CP049918.1|WP_003810617.1|2172305_2172674_-|aspartate-1-decarboxylase
MQRIMLRAKLHRVTVTEADLHYEGSCGIDEDLLDAAGMREFERIELYNVTNGERFDTYIIKAARGSGAISLNGAAARRAQVGDLLIICTYGPMSEEQSATHKPQVVLVDDANRVKEIRKFPA
>NZ_CP049918.1|WP_003810615.1|2172804_2173677_-|MOSC-domain-containing-protein
MSTRIRSLHIYPVKSCAGIDLAESIVDRAGLAHDRRWMVTTAAGQFMTQRQYPQMARIRTALEDGMLVLRAPGMEDLRIPADGSELAERTQPVGVWRDTVIARAEHPRSAEWLSRFLGLPCRLLKIDLRADRSANPEWVDTWLERHPEWAEDFAGDHFFGFADGFPLLVANQSSLDELNERLAARGQAPVPMNRFRANIVVEGDWPAFEEDQTACIVAGGVRMAFVKPCTRCPMPNVDQVTAEVYDEPGLTLTTFRSLEIGVVFGQNAIVDRTAPAPLRVGDAVEIELDF
>NZ_CP049918.1|WP_010926765.1|2173753_2174656_-|GntR-family-transcriptional-regulator
MALSAIEPFALDRSGATPLHAQVADAIRNHIRDHRLTAGTVLPSEAALCHSFGVARSVVRQALGALVAEGLIRRDPGRAPVVAPPREHRRMVQRSAGLYEQFAGLGVALRTRVLACRPAEPPPEVAAFFGTTETLLLERLRSVDAQPLAYVRTWLPRAAIAGLAADHLQDASLHRVLAQRFGLRPGRGRNRIRAVAAEAALAQALDVAPGSPLLMLEGQGLDQDGHPLEWFTTWHRPENLVFDVDVGQERESVQPALTCGTAAVAPPAVAAPPSGALDAVEQSLLQALQAVRRARGDQQE
>NZ_CP049918.1|WP_033447328.1|2174660_2175716_-|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA
MTQDATPSRIPTLAVTLGDVAGIGPEITAKMLLGHDELRQRARLLVVGDAAVLAQAVQAVGGDPARVRVIATPAEATNQPGSIEVIQAGPSLAHVPPGQLSAEAGDGSVRYVTTACALARDGLIDGIVTAPLNKAAMHMAGHKWPGHTELLAHEFGVKTFSLVLSAGDLYIFHATTHVSLRQAIEDVNPQRMRAVLRLAGSFARALGRADHPVAVAGLNPHAGENGIFGTEDAEILAPAVAQANAEGILAAGPIPADALFPQAVRGKWKFVIACYHDQGHAPFKSVYGDDGVNITVGLPVVRVSVDHGTAFDIAGKGIAREDSLVLAAERAAQLAAGWHQVWETARSTTGG
>NZ_CP049918.1|WP_003810609.1|2175712_2176930_-|four-carbon-acid-sugar-kinase-family-protein
MGGPYIGIVADDLTGSGDTAVQFVRAGWATQLSVGGAEQALADPAVRQAEVLAVTTHSRPLAAADAAAVVRGEVERLRAAGVQRLYKKVDSTLRGAFKAEIDAARLAWGEDAIAVVCPAFPVTGRTVRQGVLYVGDRPVTETSAATDPVTPVTESHIPTLLGCAQLAAQAGETPAELARRIAAAAPVVVVDALDDADVQRLARAIGVLGQRAVPVGSGGLAAPLARVWAGGQAAGPVLVVVTSQHSAARQQAAALQQAGARTWAPTLAQLADDRNWAAWTAEVEAAEHGMPAVDALMLLAPEGRLAGLDADSVARRLGELAARLVLAHGAAGVVATGGDGASAVLAALQASGIALVDEVTGGVPLGTLTGGQAAGLPVVTKAGGFGEQDVLIRAAQAIRERRFTK
>NZ_CP049918.1|WP_165645843.1|2176930_2177953_-|2-keto-3-deoxygluconate-permease
MTTEVSRVPFYTTMMKVPGGLMLLPLILGSLLGTFAPDALAIGGFTTALFKNSALPLIALLIFATGTQVNMRTGGPILATAGTILLMKTLVPATLIILLGHFVGLDGVMGISILAMLAAFDNSNGGLWLAYTGQYGDSRDRGAYVASAVNDGPFFSLLFLGASGLADIPTIALVAALVPFLLGVVVGNLDIEWRNVLKPVPNIVIPFFAFALGTGINLGAVISGGMSGLVLGLLISPITGALVYFGYRYILRRGGKSGLGFAAGTTAGNAIATPAVVAAADPSFQPYVATATAQVAACVLISSILAPVLASYFLKRAGELKPVEQEPQDGRAGQPAEVSL
>NZ_CP049918.1|WP_003810603.1|2178202_2179129_-|ectoine-hydroxylase
MISPAQDPYASRTDRSSAIIARQDPVVYGEGKFADALSADQVQSYERDGFLLLENLFSDEEVAALLAEVERMTRDPAIVRREEAITEPGSNAVRSIFMVHVLSPILGRLVRDPRLANAARQILGSEVYIHQSRANMKPGFKGKEFYWHSDFETWHVEDGMPSMRALSCSVLLTDNNETNGPLMLVPGSHRQFISCVGETPRDHYKQSLKKQEYGVPDPVSLQLLAEQGGISTMTGKAGSVVFFDCNTMHGSNSNISPWPRANVFMVYNSMENTLNPPKYGLNPRPEHIATRQAFKAVRPLDSLKLVER

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Crispr_ID: NZ_CP049918_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049918_5

2753294-2753380

Orphan

Consensus_repeat	Method
CTGTCCCCGCGGGGACAGGCACACT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049918_5

>merge|NZ_CP049918|5|2753294-2753380|CRISPRCasFinder
CTGTCCCCGCGGGGACAGGCACACTGCCGTACGCCATCGACGCTAGCCCGCCAAGACGGTATCTGTCCCTGCGGGGACAGGCACACT

>NZ_CP049918|5|5|2753294-2753380|CRISPRCasFinder
CTGTCCCCGCGGGGACAGGCACACT	GCCGTACGCCATCGACGCTAGCCCGCCAAGACGGTAT
CTGTCCCTGCGGGGACAGGCACACT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049918.1\|WP_003809603.1\|2747469_2748792_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270236
NZ_CP049918.1\|WP_004568205.1\|2747051_2747369_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049918.1\|WP_033467342.1\|2752617_2753262_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_CP049918.1\|WP_165645886.1\|2748868_2750578_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224099
NZ_CP049918.1\|WP_003809618.1\|2741879_2742482_+\|YhbY-family-RNA-binding-protein	unknown	unknown	gnl\|CDD\|198171
NZ_CP049918.1\|WP_003809588.1\|2754357_2757600_-\|carbamoyl-phosphate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|235393
NZ_CP049918.1\|WP_004568207.1\|2760793_2761603_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224041
NZ_CP049918.1\|WP_003809596.1\|2751707_2752607_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP049918.1\|WP_003809576.1\|2762741_2763992_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NZ_CP049918.1\|WP_003809579.1\|2761595_2762636_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270367
NZ_CP049918.1\|WP_003809582.1\|2759995_2760790_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223673
NZ_CP049918.1\|WP_033448474.1\|2757610_2758765_-\|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|237139
NZ_CP049918.1\|WP_033458552.1\|2758991_2759954_+\|transaldolase	unknown	unknown	gnl\|CDD\|235381
NZ_CP049918.1\|WP_165645887.1\|2750574_2751660_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361
NZ_CP049918.1\|WP_003809615.1\|2742836_2743313_-\|transcription-elongation-factor-GreA	unknown	unknown	gnl\|CDD\|234693
NZ_CP049918.1\|WP_003809610.1\|2745604_2746918_-\|pyrimidine-permease	unknown	unknown	gnl\|CDD\|132655
NZ_CP049918.1\|WP_003809590.1\|2753442_2754207_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235910
NZ_CP049918.1\|WP_003809572.1\|2764724_2765051_-\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|234669
NZ_CP049918.1\|WP_151212874.1\|2743936_2745574_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|185001
NZ_CP049918.1\|WP_003809574.1\|2764066_2764675_-\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616

Protein	Function_ID	Function_description	E-value
NZ_CP049918.1\|WP_003809603.1\|2747469_2748792_+\|extracellular-solute-binding-protein	gnl\|CDD\|270236	cd13518, PBP2_Fe3_thiamine_like, Substrate binding domain of iron and thiamine transporters-like, a member of the type 2 periplasmic binding fold superfamily. The periplasmic iron binding protein plays an essential role in the iron uptake pathway of Gram-negative pathogenic bacteria from the Pasteurellaceae and Neisseriaceae families and is critical for survival of these pathogens within the host. On the other hand, thiamin is an essential cofactor in all living systems. Thiamin diphosphate (ThDP)-dependent enzymes play an important role in carbohydrate and branched-chain amino acid metabolism. Most prokaryotes, plants, and fungi can synthesize thiamin, but it is not synthesized in vertebrates. These periplasmic domains have high affinities for their respective substrates and serve as the primary receptor for transport. After binding iron and thiamine with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The iron- and thiamine-binding proteins belong to the PBPI2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.02894e-39
NZ_CP049918.1\|WP_033467342.1\|2752617_2753262_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	1.36268e-70
NZ_CP049918.1\|WP_003809588.1\|2754357_2757600_-\|carbamoyl-phosphate-synthase-large-subunit	gnl\|CDD\|235393	PRK05294, carB, carbamoyl-phosphate synthase large subunit.	0
NZ_CP049918.1\|WP_003809618.1\|2741879_2742482_+\|YhbY-family-RNA-binding-protein	gnl\|CDD\|198171	smart01103, CRS1_YhbY, Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly. GFP fused to a single-domain CRM protein from maize localises to the nucleolus, suggesting that an analogous activity may have been retained in plants. A CRM domain containing protein in plant chloroplasts has been shown to function in group I and II intron splicing. In vitro experiments with an isolated maize CRM domain have shown it to have RNA binding activity. These and other results suggest that the CRM domain evolved in the context of ribosome function prior to the divergence of Archaea and Bacteria, that this function has been maintained in extant prokaryotes, and that the domain was recruited to serve as an RNA binding module during the evolution of plant genomes. YhbY has a fold similar to that of the C-terminal domain of translation initiation factor 3 (IF3C), which binds to 16S rRNA in the 30S ribosome.	1.06237e-30
NZ_CP049918.1\|WP_165645886.1\|2748868_2750578_+\|iron-ABC-transporter-permease	gnl\|CDD\|224099	COG1178, ThiP, ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism].	8.13837e-90
NZ_CP049918.1\|WP_004568207.1\|2760793_2761603_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	5.87905e-116
NZ_CP049918.1\|WP_003809596.1\|2751707_2752607_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	7.08863e-33
NZ_CP049918.1\|WP_003809576.1\|2762741_2763992_-\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	6.00173e-142
NZ_CP049918.1\|WP_003809579.1\|2761595_2762636_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270367	cd13649, PBP2_Cae31940, Substrate binding domain of an uncharacterized protein similar to ABC-type transporter for thiamin biosynthetic pathway intermediates; a member of the type 2 periplasmic binding fold superfamily. This subfamily includes the periplamic-binding protein Cae31940 which is phylogenetically similar to the ThiY/THI5 family. ThiY is the periplasmic N-formyl-4-amino-5-(aminomethyl)-2-methylpyrimidine (FAMP) binding component of the ABC transport system (ThiXYZ). FAMP is imported into cell by the transporter, where it is then incorporated into the thiamin biosynthetic pathway. The closest structural homologs of ThiY are THI5, which is responsible for the synthesis of 4-amino-5-(hydroxymethyl)-2-methylpyrimidine phosphate (HMP-P) in the thiamin biosynthetic pathway of eukaryotes, and periplasmic binding proteins involved in alkanesulfonate/nitrate and bicarbonate transport. After binding the ligand, They interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ThiY/THI5 proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.02712e-131
NZ_CP049918.1\|WP_003809582.1\|2759995_2760790_-\|ABC-transporter-permease	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	8.9481e-72
NZ_CP049918.1\|WP_033448474.1\|2757610_2758765_-\|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	gnl\|CDD\|237139	PRK12564, PRK12564, carbamoyl-phosphate synthase small subunit.	0
NZ_CP049918.1\|WP_033458552.1\|2758991_2759954_+\|transaldolase	gnl\|CDD\|235381	PRK05269, PRK05269, transaldolase B; Provisional.	0
NZ_CP049918.1\|WP_165645887.1\|2750574_2751660_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	8.30228e-149
NZ_CP049918.1\|WP_003809615.1\|2742836_2743313_-\|transcription-elongation-factor-GreA	gnl\|CDD\|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	7.10406e-83
NZ_CP049918.1\|WP_003809610.1\|2745604_2746918_-\|pyrimidine-permease	gnl\|CDD\|132655	TIGR03616, Putative_pyrimidine_permease_RutG, pyrimidine utilization transport protein G. This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the uracil-xanthine permease family defined by TIGR00801. As well as the The Nucleobase:Cation Symporter-2 (NCS2) Family (TC 2.A.40).	0
NZ_CP049918.1\|WP_003809590.1\|2753442_2754207_-\|SDR-family-oxidoreductase	gnl\|CDD\|235910	PRK07024, PRK07024, SDR family oxidoreductase.	4.78988e-141
NZ_CP049918.1\|WP_003809572.1\|2764724_2765051_-\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|234669	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein.	6.20353e-44
NZ_CP049918.1\|WP_151212874.1\|2743936_2745574_+\|HAMP-domain-containing-protein	gnl\|CDD\|185001	PRK15041, PRK15041, methyl-accepting chemotaxis protein.	9.25666e-118
NZ_CP049918.1\|WP_003809574.1\|2764066_2764675_-\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	7.18255e-106

>NZ_CP049918.1|WP_033467342.1|2752617_2753262_+|histidine-phosphatase-family-protein
MTEIWFIRHGETDWNRQRRLQGWQDIPLNESGREQARLLAERLRDTASERPFAALYSSDLKRAHDTAASLSAALQLRVRTEPGIRERGFGVLEGLEMENLEQQAPQAAQAWRSRDPLRALEGGETLGQFQARIIATVDDLAARHAGERILAVTHGGALDIIWRHASGVPLDAPRYAALLNVSINRVAIAQRKWEVLGWGDVEHIGAETGNDVTP
>NZ_CP049918.1|WP_003809596.1|2751707_2752607_+|LysR-family-transcriptional-regulator
MEIYQIRAFVTVARLGNLTKAAEALSLTQPAVTAQLKALEQSLGVALFDRAAGRLSLAKAGEALLPTAEALLVLGAQLKSEARQLQGQLQGVIDLGVPSEQPDFLRLGELAAALRQRLPLVELKTHVLPSTALLEQVGTARLAGALTIVAHPPRGVTWHALRSVRYRIALPASLADTLKRAGWRDIAQLPWLDGPSGSHLHLLLRDMFERHGLAPRVVMQNDDQSNLDALVRAGAGCALLREETALAGAAAGDFIVWGQARADATLGFIAPPEQAGEPMLVALISMIQKIWKPGAAVAT
>NZ_CP049918.1|WP_165645887.1|2750574_2751660_+|ABC-transporter-ATP-binding-protein
MKKVSVECRNIRLSYGRNEVLKDISIHIEPGEFFALLGPSGSGKSTLLRLIAGFNRQSHGQLLVDGRDIGATPPWDRNIGMVFQNYALWPHMTVWDNVAFGLVERRLPRAEIRDKVAAALELVGLADFGRRRPNQLSGGQQQRVALARTIVIEPQVLLLDEPLSNLDKKLRVQMRQDLLSLQRRLGITTIFVTHDQEEAMTTADRMAVLDHGVVQQIGAPSTLFDYPVNRFVANFVGTMNVLEGEVRERSRGGVVLAVDGVGELHLPVNGDAPQAGRLAASFRPHTVQIEMADGTGDARYVWLPGVVESSEFLGEFTRYQVQVGEQRLTADQHHLAGLSPFPVGAPVAVGLEPTQIRLLAA
>NZ_CP049918.1|WP_165645886.1|2748868_2750578_+|iron-ABC-transporter-permease
MTSTGTFRLPAGPALAALLVLAFLALFLVFPVGTVFYTAFVNADGSFTLGHFGAFFNQPLMKEAFFNSLYVAGWSSLLASLIAVPLAYFTVRFEFRGALLIQTLGVLPLIMPPFVGAVAMQLIFGRSGSVNLLLDNWLGITLPFMDGLNGVIFVESLHYFPFILMNLVVALRNIDGSMEEAAFNLGSRGFRLFCRIIFPLALPGYLAGTSLVFVKVFDDLGTPLVLGTTNMLAPQAYLRITQVGLEDPLGYVISVIMIGFSILALWLSARVLKGKDYSTLQKGGNAIHKRRLRPVESVLAYAWIGAVLLLVLSPHLGVLLLSLASVWSYAPLPDGYTLAHYTAVFTESQGMIANTLLYCGLAAGVDVVLGTAIAYLMLRTRLPARQWLDFIASAALAIPGIVLAIGYLRTFRGVEIPGTGVLLTSSWVLILIAYSVRRLPYALRSCVAALQQINVSLEEAAESLGASRLRTIRRIVVPLMAGGMLAGFVTSFITAAVELSATIMLVTRDSQAPMSYGIYLYMQSAAGRGPGAALGVLAVVAVGIGTYVSHLLVERASARQRPARSGESS
>NZ_CP049918.1|WP_003809603.1|2747469_2748792_+|extracellular-solute-binding-protein
MQALRPVLAAAIMAACAPALAGTVTVITSFPKDLTQAYKAAFEKAHPDIKLEILNKNTVSGIAFVRETPAGQRPEVFWASAPDAFEVLGRDKLLAKAPDVANPAVPDKIGSYPINDPSGMYMGQALAGYGIIYNTRYIKANKLPAPVEWKDLLAPHWFGHVGITAPSRSGTMHLTVETILQGEGWNDGWGTLLRMSGNASAVTERSFGVPDGVNNGQFGAGPVIDFFGLSSKYSKFPVDFVYPSETAIVPANIALIEGAKNTEEGKKFIAFTLSQAGQELLLEPKISRLPVLPYAALAGKIPPGYPDPAEIAKRSKVHFDADLSQARYYVVQSLFDQTITFRLKELQAATKAIYDAEAKLGERAGQGKAAELLAQARQLAWTPLVDAQRAADPAFLKLFAGNKKDAAVNQQITQLEGEWNGKARANYEQAQKLAREAAAL
>NZ_CP049918.1|WP_004568205.1|2747051_2747369_+|hypothetical-protein
MTVSSVSSRISAGAFDQYARQLRDRAAASGAKDEAGSPAAEALQALQRQLAAIMRQMRQVRESNATAEQQARQLQDLNRQAFAIQGQIQKLLEEQLRLAQRLAAR
>NZ_CP049918.1|WP_003809610.1|2745604_2746918_-|pyrimidine-permease
MSNTYFPRWRLADDTVPGAVIAPDERLSWPKNIAMGAQHVVAMFGSTVLAPLLMGFDPNVAILMSGIGTLIFFLFVGGRVPSYLGSSFAFIGGVVAVTGYVAPGANANIGVALGAIIACGLVYALIGLVVWAASARGNGARWIEAMMPPVVTGAVVAVIGLNLAPIAAKGAMGSSGFEASMALMTILCVGGIAVYTRGMVQRLLILVGLVLACVIYAVCANGLGLGAPMDFAKVAAAPWFGLPSFAAPVFEPQAMGLIVPVAIILVAENLGHVKAVAAMTGQDLDRYVGRAFVGDGVATMVSGAVGGTGVTTYAENIGVMAVTRIYSTLVFVVAAVIALVLGFSPKFGALIQTIPGPVLGGMSVVVFGLIAIAGARIWVVNQVDFSDNRNLIVAAVTLVLGAGDFSVKLGDFSMNGIGTATFGAIILYALLGLARRR
>NZ_CP049918.1|WP_151212874.1|2743936_2745574_+|HAMP-domain-containing-protein
MPMLERIKVRTAMVAVFACFLAVLMLSGALTWRNAGRSAAEIEGLNQVAVNQVDPLFEASGAALRARVALLEALANLQANHLDPVATLHQQAGAAQRQAATQFQRYVDVPKEPAAAELAATLQTRWRAYQSVLDELAAAVDAGQAEPALAAMNRAQQAEHAFQRDMEAFLARVQAHSDEVRSGAEDTHVVARWSAIALAALGVLLTLAGWLFVRRAVLRPLLEAGHHFDRIADGDLTARIEVRSANEIGALFAALKRMQEGLTRTIAVMRRGVDEINVGAAEISAGNANLSSRTEEQAAALEETAATMEELATTVKQNADNAAQANQLAAVSMQVAQRGGESVAQVVQTMHGISASSRQIADIVTMIDGIAFQTNILALNAAVEAARAGEQGKGFAVVAGEVRSLAQRAAQAAKEIKALIESSVATVRAGSQQVASAGGTMDEVVASVQRVADIMGEISAASAQQASGIDQVSLAISQMDETTQQNAALVEQAAAAATAMEEQARHLAAAAAVFRTQGGAIIDVAAAPLAGPAGGHAALPPAAAR
>NZ_CP049918.1|WP_003809615.1|2742836_2743313_-|transcription-elongation-factor-GreA
MSAIPLTVRGAERLQQELHRLKTVERPAVISAIAEARAQGDLSENAEYDAARERQGFIEGRISELEGTLSNAHLIDPTALDAEGRAVFGATVEIEDLDSGDRLTYQIVGDVEADIKSNLISVSSPVARALIGKSEGDVVEVKVPAGVREYEVIGVRYL
>NZ_CP049918.1|WP_003809618.1|2741879_2742482_+|YhbY-family-RNA-binding-protein
MPILELTSRERSDLRSAAHPLRPVVLIGDNGLTDAVLKEIDLALTAHELIKVRAGGDDREAREAMLATICDTLSCAAVHHLGKTLILFRPDLRAAAAKAAADTPAKRRPSEPHTPKKMAAEGKRLTKTRPARKAAEAAAPAAGARPGRDDLNQAGRPARPSTRKASPGHAIPRRSGSALSLRAGARGGLAGRKPARANKR
>NZ_CP049918.1|WP_003809590.1|2753442_2754207_-|SDR-family-oxidoreductase
MQHVFITGASSGLGQALARRYAADGARLGLLGRRAQALEALASSLPGQHRCYAVDVRDRAALHAAAQDFIAHCGGRVDVVIASAGVSAGTLTEAGEDYAVFKEIVDTNLLATVATFEPFIAGMRAARAGRLVGIASVAGVRGLPGAGAYSASKAAVATYCESLRLELAQAGVRVVTIAPGYVKTAMTAHNPYAMPFLMEADAFAGRAHAAIARGVSYRVIPWQMGVVAKLMRLLPDAVYDRLARDAPRKPRRGQ
>NZ_CP049918.1|WP_003809588.1|2754357_2757600_-|carbamoyl-phosphate-synthase-large-subunit
MPKRTDLKSILIIGAGPIIIGQACEFDYSGAQACKALKAEGYRTILVNSNPATIMTDPETADVTYIEPITWQAVEKIIEREKPDALLPTMGGQTALNCALDLAHHGVLKKHNVELIGANEHAIEKAEDRQKFKQAMTDIGLESAKSGVAHSMDEAWEVQRRIAADIGTAGFPVVIRPSFTLGGSGGGIAYNAEEFEVICRRGLEASPTKELLIEESLLGWKEFEMEVVRDKADNCIIVCSIENLDPMGVHTGDSITVAPAQTLTDKEYQIMRNASIAVLREIGVDTGGSNVQFAVNPQNGRMIVIEMNPRVSRSSALASKATGFPIAKVAARLAVGYTLDELRNEITGGATPASFEPTIDYVVTKVPRFAFEKFPQADARLTTQMKSVGEVMAMGRTFQESFQKALRGLEVGVDGLNQKTTDREKLQIELGEPGPERIWYVGDAFAQGFTLDEVHGLTRIDPWFLAQIKEIVDIELALEQKTLADLDYATLWELKRRGFSDRRLAFLLDSSESEVRKLRHQLNVRPVYKRVDTCAAEFATNTAYMYSTYEEECESQPTDRKKIIVLGGGPNRIGQGIEFDYCCVHAALALREDGYETIMVNCNPETVSTDYDTSDRLYFEPLTLEDVLEIVHKENPVGMIVQYGGQTPLKLARALEANGVPIIGTSPESIDVAEDRERFQKLLNKLGLRQPPNRTARTEAEALAHASEIGYPLVVRPSYVLGGRAMEIVHEQQDLERYMREAVKVSNDSPVLLDRFLNDATEVDVDCLADGQTVFIGGVMEHIEQAGVHSGDSACSLPPYSLSAEVIAEIKRQTTMMAKALNVSGLMNVQFAIQGGDVYVLEVNPRASRTVPYVSKATGLQLAKIAARAMAGRTLADQGITREVVPPYFSVKEAVFPFVKFPGVDTILGPEMKSTGEVMGVGNSFGEAFVKSQLAAGVRLPDSGTVFISVRNQDKPRAVEVARGLHNLGFKLVATRGTAAEIEAAGIPVQVVNKVTEGRPHIVDMVKNGEVSLVINTVEERRNAIADSRTIRTQALANRITFFTTIAGARAAVEGMQFMRQGLGLQVYPLQELHAGLTAQ
>NZ_CP049918.1|WP_033448474.1|2757610_2758765_-|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit
MLPQLFPEGINRFPPAILALADGTIFRGVSIGAPGHTVAEVVFNTSMTGYQEILTDPSYAGQTVMLTYPHIGNTGVNPEDVEANRVYAAGLVVRDCPARVSNFRATQSLPEYLNAQGIVAIAGIDTRKLTRILRESGAQGSCILVGEDAERAVELARGFPGMSGQDLAKVVSIKERADWTQGTWELGSGYTQPAQDRFHVVAYDYGVKSNILRLLADRGCRVTLVPAQTTAEEAFKLQPDGVFLSNGPGDPEPCDYAVDATRAFLERKLPVFGICLGHQLMGLALGGKTVKMKTGHHGANHPVQDVQSGRVFITSQNHGFAVDAATLPANTRVTHISLFDGTLQGFELTDRPAFCFQGHPEASPGPHDIIVLFDKFISLMAGQK
>NZ_CP049918.1|WP_033458552.1|2758991_2759954_+|transaldolase
MPSQLEALRRHTVVVADTGDFEAMRALRPTDATTNPSLILKAVQQEAYRPLLVQTARAHQGASPAEITDRLLVAFGRQILDIVPGRVSTEVDARLSFDTRATVERARGLIALYQAAGVPRERVLIKIASTWEGIQAARVLQAEGIRCNLTLLFCLPQAAACADAGVQLISPFVGRIYDWHKKNAGAEWVEDARRGANDPGVQSVSRIYRYYKRFGIETEIMGASFRNVDQILALAGCDLLTISPELLTRLSQTEGEVPAALSPQAGHDDADAVRLDGGEVAFRTQLNEDAMASEKLSEGIRLFVADARKLDALVESHGAA
>NZ_CP049918.1|WP_003809582.1|2759995_2760790_-|ABC-transporter-permease
MSKLIKPGSLSLRFWQLLLFVVILLVWHAASRDPKVAFFFGEPLKVWGRIWAWFVSNGDIYGHLWVTLSETVLAFFIGTVSGLGFGLWLGLSPGASAILDPYIKAANSMPRVILAPIFGMWFGLGIWSKVALAVTLVFFIVFFNVYQGVREVSPTLLDNARMLGARRRQLLRHVYLPSATSWVFSSLHTSVGLAFVGAVVGEYLGSASGVGYLILQAEGTFDVNTVFAGIVVLTAFALLLDYVVGMGEKRLMKWQPKSGETEKL
>NZ_CP049918.1|WP_004568207.1|2760793_2761603_-|ABC-transporter-ATP-binding-protein
MAEAALSLEGITCTFIAREDRSRRYTAVQDTSLAVAPGEFVSVVGPTGCGKSTLLNVGAGLLAPSSGTVRVFGQALAGINERAGYMFQGEALLPWRSALENVVAGLDFAGVPRAEADERGREWMRRVGLGGFETRYPHQMSGGMRKRVMLAQTLIRDPDIILMDEPFSALDIQTRQLMENEVLDLWMAKRKAVLFITHDLDEAIAMSDRVIVLSAGPGTHPIGEFAIDLPRPRDVAEVRTHPRFVELHAAIWGVLREEVLKGYAQQKRA
>NZ_CP049918.1|WP_003809579.1|2761595_2762636_-|ABC-transporter-substrate-binding-protein
MSVTRRELLKLAGAAGAMSLAPAIVRAQKLEKAKVQIAVGGKPLIYYLPLTIAEVKGFFKDEGLDVSIADFAGGSKALQAVVGGSADVVSGAFEHTLSLQAKGQFYRAFALQGRAPMIGVGVSKKNLPGYKGPADLKGRKIGVTAPGSSTNMVVNFFLAKHGLKASDVSFIGVGAGAGAVTALRSGQIDAISNTDPVVSMLETSGDIQIIVDTRTLKDTKEIFGGNMPAGCLYAPQAFVDANPNTAQALTNAIVRADKWIQKAGADEIAKAVPEGYLLGDPAVYKAAIGKSMEGLSPDGVIPEDGAATALKALAAFVPDFDAAKVDPAKAWTNEYTRRANEKYPNG
>NZ_CP049918.1|WP_003809576.1|2762741_2763992_-|CoA-transferase
MSALKGLKVLELGTLIAGPFAARMFGEFGAEVIKVETPHGPDGTGGGDPIRSWRHLHRGDSLWWTVQARNKQSIALNLKDPRAQEIARRLALEADVVVENYRPGVLEKWGLGYEQLRAINPATIMVRLSGYGQTGPLRDLPGFGAIGESMGGLRYVSGHPDRPPVRVGISIGDSLAALHGVIGALMALRHRDATGGRWNGATGEQCQAGQGQMVDVALYESVFNMMESLVPEYDVAGVVRERTGGALPGIVPSNTYTTRDGQNIVIAGNGDAIFHRLMLAIGRSDLAHDPQLERNDGRARRATEIDSAIQRWCDTHTIEQALATLRAADVPVGKIYSVADMFTDPQFLARGMIEQHHFPDGSPVKLPAVVPKLSETPGGTRWLGPRLGEHTEEVLRSLGYDAAAIAELAQTGAIGR
>NZ_CP049918.1|WP_003809574.1|2764066_2764675_-|recombination-protein-RecR
MDPQLPEPEPLIALIEALRRLPGVGVRSARRMAYHLLQHDLQGADMLGRALSGAVQHLRHCARCNSFTEDEVCATCANPKRDPGLLCIVETPADQNMIESSHGYRGLYYVLMGRIAPLEGVGPRELDFQRVIERACDGVVQEVILATNFTAEGETTAHFLGDALSERGLKVTRLARGVPAGSELEYVDAGTIAWALMERRST
>NZ_CP049918.1|WP_003809572.1|2764724_2765051_-|YbaB/EbfC-family-nucleoid-associated-protein
MMKGQLAGLMRQAQQMQENMKKAQDALAEIQVEGAAGGGLVKVTMTCRHDVKRVAIDPSLLGEDKDMLEDLVAAAFNDALRKAEATSQEKMASVTAGMPLPPGMKLPF

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Crispr_ID: NZ_CP049918_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049918_6

3282177-3282262

Orphan

Consensus_repeat	Method
CTGTCCCCGCGGGGACAGGCACAC	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP049918_6

>merge|NZ_CP049918|6|3282177-3282262|CRISPRCasFinder
CTGTCCCCGCGGGGACAGGCACACTGTCATACGCCATGAACACTAGCCTGCCAAGACGGTATCTGTCCCCGCGGGGACAGGCACCC

>NZ_CP049918|6|6|3282177-3282262|CRISPRCasFinder
CTGTCCCCGCGGGGACAGGCACAC	TGTCATACGCCATGAACACTAGCCTGCCAAGACGGTAT
CTGTCCCCGCGGGGACAGGCACCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049918.1\|WP_003808563.1\|3291276_3291615_+\|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|223713
NZ_CP049918.1\|WP_003808589.1\|3279654_3280425_+\|phosphonate-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213223
NZ_CP049918.1\|WP_003808591.1\|3278644_3279652_+\|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270291
NZ_CP049918.1\|WP_003808574.1\|3285908_3286418_+\|pantetheine-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|234674
NZ_CP049918.1\|WP_003808567.1\|3287945_3288332_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|281474
NZ_CP049918.1\|WP_033446134.1\|3274531_3275032_-\|transcription-antitermination-factor-NusB	unknown	unknown	gnl\|CDD\|234686
NZ_CP049918.1\|WP_003808594.1\|3277668_3278496_+\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_CP049918.1\|WP_003808568.1\|3286720_3287938_+\|benzoate/H(+)-symporter-BenE-family-transporter	unknown	unknown	gnl\|CDD\|281578
NZ_CP049918.1\|WP_042143348.1\|3273475_3274474_-\|thiamine-phosphate-kinase	unknown	unknown	gnl\|CDD\|235583
NZ_CP049918.1\|WP_033456389.1\|3284013_3285192_-\|signal-recognition-particle-docking-protein-FtsY	unknown	unknown	gnl\|CDD\|236686
NZ_CP049918.1\|WP_003808562.1\|3291611_3292118_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176905
NZ_CP049918.1\|WP_010927717.1\|3276865_3277663_+\|HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|273651
NZ_CP049918.1\|WP_003808598.1\|3275003_3275531_-\|6,7-dimethyl-8-ribityllumazine-synthase	unknown	unknown	gnl\|CDD\|234606
NZ_CP049918.1\|WP_003808597.1\|3275544_3276720_-\|3,4-dihydroxy-2-butanone-4-phosphate-synthase	unknown	unknown	gnl\|CDD\|237587
NZ_CP049918.1\|WP_015064460.1\|3285267_3285888_+\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	unknown	unknown	gnl\|CDD\|223813
NZ_CP049918.1\|WP_003808587.1\|3280421_3281312_+\|phosphonate-ABC-transporter,-permease-protein-PhnE	unknown	unknown	gnl\|CDD\|273441
NZ_CP049918.1\|WP_010925999.1\|3282368_3283967_+\|CYTH-and-CHAD-domain-containing-protein	unknown	unknown	gnl\|CDD\|143624
NZ_CP049918.1\|WP_003808566.1\|3288328_3290848_-\|AsmA-family-protein	unknown	unknown	gnl\|CDD\|236772
NZ_CP049918.1\|WP_003808584.1\|3281308_3282130_+\|phosphonate-ABC-transporter,-permease-protein-PhnE	unknown	unknown	gnl\|CDD\|273441
NZ_CP049918.1\|WP_003808570.1\|3286472_3286724_+\|YfhL-family-4Fe-4S-dicluster-ferredoxin	unknown	unknown	gnl\|CDD\|319871

Protein	Function_ID	Function_description	E-value
NZ_CP049918.1\|WP_003808563.1\|3291276_3291615_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|223713	COG0640, ArsR, Predicted transcriptional regulators [Transcription].	2.51065e-15
NZ_CP049918.1\|WP_003808589.1\|3279654_3280425_+\|phosphonate-ABC-transporter-ATP-binding-protein	gnl\|CDD\|213223	cd03256, ABC_PhnC_transporter, ATP-binding cassette domain of the binding protein-dependent phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all kingdoms of wildlife, but only prokaryotic microorganisms are able to cleave this bond. Certain bacteria such as E. coli can use alkylphosphonates as a phosphorus source. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	6.7095e-115
NZ_CP049918.1\|WP_003808591.1\|3278644_3279652_+\|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270291	cd13573, PBP2_PnhD_3, Substrate binding domain of uncharacterized ABC-type phosphonate-like transporter; contains the type 2 periplasmic binding fold. This subfamily includes putative periplasmic binding component of an ABC transport system similar to alkylphosphonate binding domain PnhD. These domains are found in PnhD-like proteins that are predicted to function as initial receptors in hypophosphite, phosphonate, or phosphate ABC transport in archaea and eubacteria. They belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.92107e-151
NZ_CP049918.1\|WP_003808574.1\|3285908_3286418_+\|pantetheine-phosphate-adenylyltransferase	gnl\|CDD\|234674	PRK00168, coaD, phosphopantetheine adenylyltransferase; Provisional.	3.03384e-101
NZ_CP049918.1\|WP_003808567.1\|3287945_3288332_-\|hypothetical-protein	gnl\|CDD\|281474	pfam03476, MOSC_N, MOSC N-terminal beta barrel domain. This domain is found to the N-terminus of pfam03473. The function of this domain is unknown, however it is predicted to adopt a beta barrel fold.	7.15282e-08
NZ_CP049918.1\|WP_033446134.1\|3274531_3275032_-\|transcription-antitermination-factor-NusB	gnl\|CDD\|234686	PRK00202, nusB, transcription antitermination factor NusB.	1.02433e-51
NZ_CP049918.1\|WP_003808594.1\|3277668_3278496_+\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	9.15813e-52
NZ_CP049918.1\|WP_003808568.1\|3286720_3287938_+\|benzoate/H(+)-symporter-BenE-family-transporter	gnl\|CDD\|281578	pfam03594, BenE, Benzoate membrane transport protein.	3.72852e-112
NZ_CP049918.1\|WP_042143348.1\|3273475_3274474_-\|thiamine-phosphate-kinase	gnl\|CDD\|235583	PRK05731, PRK05731, thiamine monophosphate kinase; Provisional.	1.12252e-133
NZ_CP049918.1\|WP_033456389.1\|3284013_3285192_-\|signal-recognition-particle-docking-protein-FtsY	gnl\|CDD\|236686	PRK10416, PRK10416, signal recognition particle-docking protein FtsY; Provisional.	1.12987e-174
NZ_CP049918.1\|WP_003808562.1\|3291611_3292118_+\|SRPBCC-family-protein	gnl\|CDD\|176905	cd08896, SRPBCC_CalC_Aha1-like_3, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	7.32648e-83
NZ_CP049918.1\|WP_010927717.1\|3276865_3277663_+\|HAD-IIB-family-hydrolase	gnl\|CDD\|273651	TIGR01484, Putative_mannosyl-3-phosphoglycerate_phosphatase, HAD-superfamily hydrolase, subfamily IIB. This subfamily falls within the Haloacid Dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. The Class II subfamilies are characterized by a domain that is located between the second and third conserved catalytic motifs of the superfamily domain. The IIB subfamily is distinguished from the IIA subfamily (TIGR01460) by homology and the predicted secondary structure of this domain by PSI-PRED. The IIB subfamily's Class II domain has the following predicted structure: Helix-Sheet-Sheet-(Helix or Sheet)-Helix-Sheet-(variable)-Helix-Sheet-Sheet. The IIB subfamily consists of Trehalose-6-phosphatase (TIGR00685), plant and cyanobacterial Sucrose-phosphatase and a closely related group of bacterial and archaeal sequences, eukaryotic phosphomannomutase (pfam03332), a large subfamily ("Cof-like hydrolases", TIGR00099) containing many closely related bacterial sequences, a hypothetical equivalog containing the E. coli YedP protein, as well as two small clusters containing OMNI\|TC0379 and OMNI\|SA2196 whose relationship to the other groups is unclear. [Unknown function, Enzymes of unknown specificity].	7.51884e-15
NZ_CP049918.1\|WP_003808598.1\|3275003_3275531_-\|6,7-dimethyl-8-ribityllumazine-synthase	gnl\|CDD\|234606	PRK00061, ribH, 6,7-dimethyl-8-ribityllumazine synthase; Provisional.	4.04555e-65
NZ_CP049918.1\|WP_003808597.1\|3275544_3276720_-\|3,4-dihydroxy-2-butanone-4-phosphate-synthase	gnl\|CDD\|237587	PRK14019, PRK14019, bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II.	0
NZ_CP049918.1\|WP_015064460.1\|3285267_3285888_+\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	gnl\|CDD\|223813	COG0742, COG0742, N6-adenine-specific methylase [DNA replication, recombination, and repair].	2.15121e-57
NZ_CP049918.1\|WP_003808587.1\|3280421_3281312_+\|phosphonate-ABC-transporter,-permease-protein-PhnE	gnl\|CDD\|273441	TIGR01097, PhnE, phosphonate ABC transporter, permease protein PhnE. Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions].	2.14802e-90
NZ_CP049918.1\|WP_010925999.1\|3282368_3283967_+\|CYTH-and-CHAD-domain-containing-protein	gnl\|CDD\|143624	cd07756, CYTH-like_Pase_CHAD, Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain. This subgroup belongs to the CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) superfamily. Members of this superfamily hydrolyze triphosphate-containing substrates, require metal cations as cofactors, and have a unique active site located at the center of an eight-stranded antiparallel beta barrel tunnel (the triphosphate tunnel). A number of proteins in this subgroup also contain a C-terminal CHAD (Conserved Histidine Alpha-helical Domain) domain which may participate in metal chelation or act as a phosphor-acceptor. The name CYTH originated from the gene designation for bacterial class IV adenylyl cyclases (CyaB) and from thiamine triphosphatase. Class IV adenylate cyclases catalyze the conversion of ATP to 3',5'-cyclic AMP (cAMP) and PPi. Thiamine triphosphatase is a soluble cytosolic enzyme which converts thiamine triphosphate to thiamine diphosphate. This domain superfamily also contains RNA triphosphatases, membrane-associated polyphosphate polymerases, tripolyphosphatases, nucleoside triphosphatases, nucleoside tetraphosphatases and other proteins with unknown functions. Proteins of this subgroup have not been characterized.	5.2147e-56
NZ_CP049918.1\|WP_003808566.1\|3288328_3290848_-\|AsmA-family-protein	gnl\|CDD\|236772	PRK10833, PRK10833, putative assembly protein; Provisional.	2.80816e-30
NZ_CP049918.1\|WP_003808584.1\|3281308_3282130_+\|phosphonate-ABC-transporter,-permease-protein-PhnE	gnl\|CDD\|273441	TIGR01097, PhnE, phosphonate ABC transporter, permease protein PhnE. Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions].	1.08607e-97
NZ_CP049918.1\|WP_003808570.1\|3286472_3286724_+\|YfhL-family-4Fe-4S-dicluster-ferredoxin	gnl\|CDD\|319871	cd10549, MtMvhB_like, Uncharacterized polyferredoxin-like protein. This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.	1.53234e-06

>NZ_CP049918.1|WP_003808584.1|3281308_3282130_+|phosphonate-ABC-transporter,-permease-protein-PhnE
MNTSVTSLEPGHPRTWQRYSGGQKALRFMLYLLLVAAIVQAVRSVEVIPEFLYDAPEQMADLLRRMWPIDWSYYPEGVHAALVETLHIATLGTILSVGMAVPVGLLAANNLTPSRTINMLARLILVSSRSVNSLVWALLFIAIFGPGALAGTLAIAFRSIGFVGKLVGEAIEEAQRGPIEALTATGASKAAVLWYGYWPQIRPSFWSIVLLRWDINVRESAVLGLVGAGGIGMALDTALNLFQWDRVALVLAAIFIVVVAAEIVITQARKRIL
>NZ_CP049918.1|WP_003808587.1|3280421_3281312_+|phosphonate-ABC-transporter,-permease-protein-PhnE
MTVRTANMARRPFSLSWRAKTGVLLVVLYTFYAAAQLDFSWARFETGLGHAATFLARMFPPNFEKPDTLWKGIAESLEIAVLASVLGILLSLPIGLLGARNLMPAWASWPARALVALCRALHPVIVAILFVKAVGFGALAGILALTVASIGFIGKLFTEAIEEISLKQVEAVRASGASFGNVIIFGVLPQVFARFVGFATYQFDSNLRNSTMVGIVGAGGIGGTLFSAFQRFDYDFVAAILLTLIAIIMLGEILAGFVRKVFLDNMGFERILQRRFTAARGLGSTTPLARKGEVDE
>NZ_CP049918.1|WP_003808589.1|3279654_3280425_+|phosphonate-ABC-transporter-ATP-binding-protein
MATSLRITGLVKEYRAGKPVLNGIDLDIAGQGLTAIIGPSGTGKSTLLRCINRLIEPTSGEIVLKDAEGTVDLARVRGQSLRRARRRIGMVFQEYNLVERLTVMENLLTGRLGYTSALNAWMRRFDPADIERAFQLLDTVGLAGFADQRADALSGGQRQRVGIARALMQRPQLLLADEPTSSLDPKTSVEIMELLTEQGSVNGIPVLVNIHDVELARRYANRIVGMSGGHVVYDGDGKGLDATMLKTIYGGESWLE
>NZ_CP049918.1|WP_003808591.1|3278644_3279652_+|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein
MRAKRLLQAAAVTALIFGSYAAQAADAACSNRGDLDNMYCDANKDLVADTPTDKSKLKTPSTLVFTYTPVEDPAVYEDIFKPFTKHLSECTGKRVVFYQVQSNAAEIEAMRSGRLHVGGFSTGPTAFAVNIAGAVPFAVKGYADEFQGYNLIVIVKKDSPYQKLTDLKGKKLAHTAPSSNSGHMAPVALFPKEGLTPDKDYKVIFSGKHDQSVMGVNSGDYDAAAVASDVFKRMAERGQVKEEDFRVIYRSEKFPTSSFAYAHDLEPAFRDKMLKCFYDYRFPDEMKKAFDGADRFYPVTYQKDWAIVREVAESGGEKFNRAAYDRETAKSKGKQ
>NZ_CP049918.1|WP_003808594.1|3277668_3278496_+|IclR-family-transcriptional-regulator
MSAAKSTAKPAAAPGNDGRRSIQSVEVGFPLLAALVDAGRPLTLRDLAGAAGMTSAKAHPYLVSFTRVGLVQQDTVTGQYELGPFALQMGLVSLQRLDPVRVALPEVDKLQSEIGHTLGIAVLGSHGPTMIHITEASYPVHVNMRKGTVMSMLHTATGQVFAAWLPPKVAEHYIAREDGDAAVIASLTPRKTTRANLDAMLADIRVHGMARALGNPLPGVDALSVPVFDHTGGIVLALTSLGPTGLFDASFTGAIARPLLACAQEISRKLGYRGN
>NZ_CP049918.1|WP_010927717.1|3276865_3277663_+|HAD-IIB-family-hydrolase
MQALAAMPAPVAASVRIVLTDIDDTLTTEGRLPAGAYAALERLEQAGIVVVPITGRPAGWCDHIARMWPVRAVVGENGAFYYAYDRSARRMNAHYWADAATRAANRQALQAIRERVLREVPGTAVASDQDYRVADLAIDFCEDVPALPDGAVGRIVEIFHEAGAQAKVSSIHVNGWFGDYDKLTMTRTLFEREFGLNIDSALQHTLFIGDSPNDEPMFKFFPISVGVANIQSQLHRIQHRPAFVAAARGGDGFVEMAERLLANRG
>NZ_CP049918.1|WP_003808597.1|3275544_3276720_-|3,4-dihydroxy-2-butanone-4-phosphate-synthase
MSAQISSLNAGAAPESFGIASVPEIIAELRAGRIVILVDEEDRENEGDLVMAAEFVTPEAINFMVTHGRGLVCLTLTEERCRQLDLPLMASRNGTRYGTNFTQSIEAAEGVETGISAADRARTIQVAVARDAQPSDLVQPGHIFPVRAVPGGVLVRAGHTEAGCDLTAMGGLTPAAVICEILKPDGTMARLPDLVEFAREHKLKIGTIADLIQYRSEHESIIARMGERMMQTPWGDFRCIAYRDDATRSPHLALVHGNIDPERETLVRVHEPASLLDVLDTGASPHSWSVGQALHAIAASPAGVLVLMNCQSSTEHLFGQIANWAGPAERAAAQEGDRFGLRTYGIGAQILRDLNVGRMKLLARPRKMPSMAGFALTITGYDCAPPNLRND
>NZ_CP049918.1|WP_003808598.1|3275003_3275531_-|6,7-dimethyl-8-ribityllumazine-synthase
MNPYILTPDLNGEGLHIGIVRARFNEEIGQAQLQACLEELGKLGVDERDVMVVSVPGALELGVALARMAESYEFDALIALGAVIRGETYHFEVVSNESAAAISRIALETGIPVANGVLTVDTDEQAQARAAGKGADCAQVAVEMANLAAALEPEEDDEDEDDEDEDFDDEEDDGR
>NZ_CP049918.1|WP_033446134.1|3274531_3275032_-|transcription-antitermination-factor-NusB
MTTKKTTAADNAVQARANARSARRRAREFALQGVYAWLLRGGEGTQDAGEIDAHLRDAEDFSEADAQWFKTLLHGVLREAPVLRERFLPYIDRPLAELSPVEHGILLIGSFELMHHVEVPYKVAINEAVELAKSFGGTDGFKFVNGVLDKLAADVRTAEVQAAPRR
>NZ_CP049918.1|WP_042143348.1|3273475_3274474_-|thiamine-phosphate-kinase
MASEFDLIARYFTRPAPDGVLGVGDDCALFPVPPGQQVATSTDLLIEGRHFFPDVDPQALGHKALAVNLSDLAAMGARPVGCLLGLALPGVDEAWLAAFARGFQALADTHACPLIGGDTTRAPQGLLAISVTVFGAVAPGHALRRAAAQPGDDVWVSGELGAADIAYRLLDRQLPADPLRLAATRAALEWPRPRVELGMALAGLARAGIDISDGLLQDLGHILAASGVAAELRYDALPVAAALAGLPAETVRRAALGGGDVYELCFTADPAHRQAIGQAAHGAGAPVSRIGRILAGQGLRVLDADGAPLGELPGGFDHFSDATDQPAPGRRP
>NZ_CP049918.1|WP_010925999.1|3282368_3283967_+|CYTH-and-CHAD-domain-containing-protein
MSEQELKLHVPAAARAAVQQQIQQRQAARIRLHAMYFDTPGRELARARIAIRLRQEGRDWVQTLKMPGANAISRVEINHPRPGPVLDLSVYAGTEAQAALTAIKGELGLRYETDVQRLFCKVRGRHGTVELAYDTGVLRAGALELPISELEFELVSGRPAAIFAMARSWLQRHGLVLDARSKSERGDALAQLAHDLAAAPGEADDAARATRDQQAVAGFWAPRNAGAVKLDESMTPMQAMAAVAAECVDHIARNAAVLAEVDTLGVYRAGTPEHVHQLRVGVRRLRSAWRLFDGWIADPSETLAQGARTHFSAFGMARDQDVLADTIMPLLARAGMPALPAEAAPSNDNAQSLAADRAFQGWLLELLAWSLDVPPPPAPAATAEAAAASPTIIPLAPPAEAAPPALRKRLTGRLRRWHLKVIDEGLRFGALELEARHELRKRVKRLRYGLSFAESLLPAARLRTYRKQLARVQDLLGEINDLAVARDYYQAALQAHPQAWFAVGWIGARLDGLTPQAQEAFDQLAHAKPFWK
>NZ_CP049918.1|WP_033456389.1|3284013_3285192_-|signal-recognition-particle-docking-protein-FtsY
MFSFFKKKSPPPAAPAQPAPPPEAVDAGSAAPAQPQPAEPQPAPMPAPQPEPQPEPQPQQPPEPAPPAMASPPVAEPQPPVAAAPEAPRKASWLSRLKQGLSRTGQNIGGLFVGVKVDENLFEELESALIMADAGIEATEKLLAALRARVKKERIDDPAQVKTALRQLLADHLRPLERSFDLGRAQPLVVMIAGVNGAGKTTSIGKLAHTFQRQGASVLLAAGDTFRAAAREQLVEWGSRNNVTVISQDGGDPAAVAFDSVNAGRARNVGVVMVDTAGRLPTQLHLMEELKKIRRVIGKAEASAPHEVLLVVDGNTGQNALAQIRAFDAAITLTGLVVTKLDGTAKGGTLAAVAAGSQGVRPIPVYWIGVGEGLEDLQPFVADEFAAALLAD
>NZ_CP049918.1|WP_015064460.1|3285267_3285888_+|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD
MKPSRLGSKPIRIVGGLYRRTLIPVADAPGLRPTPDRVRETLFNWLNHLWGGEFADKRVLDLFAGSGALGFEAASRGAGQVQMVERDRGAAAALRTLRDKLQAGAVRIHAGDAMQVIERMDASRFDLVLLDPPFGQGWLERLWPLLPAVLAEDGLVYVESETAPAPPAGFELLREGKAGAVHYRLFQFAAMRKSMNNPALEDGASH
>NZ_CP049918.1|WP_003808574.1|3285908_3286418_+|pantetheine-phosphate-adenylyltransferase
MIIAVYPGTFDPLTRGHEDLVRRAATLFDKVVVGIAHSRNKKPFFTIEERVDIAREVLGHYPNVEVHSFGGLLKDFVRDQNGRVIIRGLRAVSDFEYEFQMAGMNRHLLPDVETMFMTPSDQYQFISGTIVREIAQLGGDVSKFVFPSVERWLQAKAKERREQSAQGGA
>NZ_CP049918.1|WP_003808570.1|3286472_3286724_+|YfhL-family-4Fe-4S-dicluster-ferredoxin
MALKITEECINCDVCEPQCPNEAISMGADYYVIDPDRCTECVGHHDEPQCKVVCPVECIELHPQWQEGQEQLMAKYRRLTGAA
>NZ_CP049918.1|WP_003808568.1|3286720_3287938_+|benzoate/H(+)-symporter-BenE-family-transporter
MNGADSASSPLAARRPVTGALSLSAIVAGLVAVLVSFGGTAVLMVQAGHAAGLDAARIGSWLGSICLALGVGGALISLRSRMPVVFAWSTPGAALLVTGLVGVPFDQAVGAFVLAAALTLACGVFGWIDPIVRRIPAELAAAMLAGVLLNFGMGIFGSIAAQPVLVLSMCAAYLLGRRWAPRFAVLAVLVVGLAAASSLDLLRLGHVQWAWTEFVWTTPSFTWQAAISLGIPLFVVAMASQNLPGLAILQAAGYRPPASRLVGLTGLAGLLAAPFGAHSVTLGAIIAALCAGPEAHADPGRRYVAAATYGLTYVLLSVAAGAVAVFFQALPGALIAALAGLALLGAIMGGMTTAMADPQRREAALVTLLATASGISFWGIGSAFWGLAAGLATHGALAWRRARSA
>NZ_CP049918.1|WP_003808567.1|3287945_3288332_-|hypothetical-protein
MSTTAYQPIAECGATTQSEAAAYQKRWLVANDAGQWLNRDLCPRLAEVSVELRMGYLVLKAPGMLRLDIPLDVIEDDDSVRYQMLVGEQTVDVVDEGELAAAWISNHAGVPCRILKVHPDMAEVRWPS
>NZ_CP049918.1|WP_003808566.1|3288328_3290848_-|AsmA-family-protein
MKTWFKRIVIGLVVLVVVAVVGLAIFLLTFDPNAYKYKLEEAVQARYERTLNIEGEIELSLFPRIGLAVQGVSLSEPNSPDVFASIDSMRLAVAVWPLLSNSLVVDHVTINGFKARVIRGKDGHFNFENLVGGSVQSTDVPGNAAEATAGAITGTAQAIVNGTVSTPKSMQIDIAGLDLKDGEIQLQDAMSGMAVAITKLNAATGRVTYNQPFDVSLSARVEGGNPRLDAGLTGQAQLTLDPLAKRYAAQRLDLRMEGRLPGAQAKSLAARGNVAFNGMTSSLDVAGLEILFQGDIVDTATKLTNVEASVAMPKLAVDPHKTELQIDKLAVRAKGAMPGGPFELAVDAPALNISPTNASGDALSGRVRTQELDASFGLNGISGNAGELDIKEAKLDSTLKQGERVVKSAFASPVTLNLLQRSIGLSALKGDVNITDPGLPKGSLQIPVIGSVNANLLKDQANARINAVLEGGKFDLSADIVALSAVPRVTFALAVDTLDLDKLAPPAGASAPPKPAGDGKQDESKPPAKPQPAPAPAAADDSINLSGLVGPTASGTIKIGQLVMRGLKAEQVAANIKLEKGKLDISTLTAALYGGKLGGVMSVDAVNGNQLVAKMSLAGIAIQPLLSDLAGKDTLSGTGSLAFDLKTAGANTYAMKSGLAGTMQVRLRDGAIKGINVAQTLRELKAMFRGEAHDPTVQDDQTRQTDFTSLESDLVFNKGVATVKRLDMAAPLLRVNQGNPANIDFVRSELDFVARVRVVNTSTGQDGKDLAELRNLTIPLLITGPFDKPVYTLQWREVAGEALKRGLEKQLKEALTGGEGASGSPAKNIDKALKGILGK
>NZ_CP049918.1|WP_003808563.1|3291276_3291615_+|helix-turn-helix-transcriptional-regulator
MPNQAAQLSQVFQALSDPTRRAVLERLCQGSAAMSELARPFNMALPSFSQHLDVLERCGLVRSRKSGRVRIYTLAPQPLGMAEHWMTRQRAIWERRLDQLDLYLQDLKEQKR
>NZ_CP049918.1|WP_003808562.1|3291611_3292118_+|SRPBCC-family-protein
MTRQHSTQPDPKLDLVLERTIDVPPALVWQAWTQPEHIKHWLTPAPWQTVRCDVDLRPGGRFRFVMRSPEGEEHTHDCCYLEIVEGSRLVWTNALLPGFRPAGGGGDVPAFTAVIRIEPHDQGTRYTATAMHGTQAGCRQHSDMGFHDGWGAALDQLVAHARNMQQAS

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Crispr_ID: NZ_CP049918_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049918_7

4290908-4291044

Orphan

Consensus_repeat	Method
ATGTTTCACGTGAAACAA	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP049918_7

>merge|NZ_CP049918|7|4290908-4291044|PILER-CR
ATGTTTCACGTGAAACATGCGGCGCCTGTTCCGACCCTCAATAATGCGATTACATGTTCCACGTGAAACAATACTCCTTGATTTGGCATTGAGGCAGACTCACTCAAGCCGTCAGCATGATGTTTCACGTGAAACAA

>NZ_CP049918|7|1|4290908-4291044|PILER-CR
ATGTTTCACGTGAAACAT	GCGGCGCCTGTTCCGACCCTCAATAATGCGATTAC
ATGTTCCACGTGAAACAA	TACTCCTTGATTTGGCATTGAGGCAGACTCACTCAAGCCGTCAGCATG
ATGTTTCACGTGAAACAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049918.1\|WP_014906142.1\|4293159_4294326_+\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|181642
NZ_CP049918.1\|WP_042145827.1\|4297588_4298965_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|182388
NZ_CP049918.1\|WP_033451346.1\|4284593_4285595_-\|asparaginase	unknown	unknown	gnl\|CDD\|199208
NZ_CP049918.1\|WP_003806883.1\|4282807_4283998_-\|elongation-factor-Tu	unknown	unknown	gnl\|CDD\|234596
NZ_CP049918.1\|WP_003816068.1\|4292553_4292760_-\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_CP049918.1\|WP_003816065.1\|4294401_4295925_-\|tripartite-tricarboxylate-transporter-TctA	unknown	unknown	gnl\|CDD\|225870
NZ_CP049918.1\|WP_003806881.1\|4285587_4286505_-\|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl\|CDD\|275105
NZ_CP049918.1\|WP_003806887.1\|4280449_4281148_-\|50S-ribosomal-protein-L1	unknown	unknown	gnl\|CDD\|180071
NZ_CP049918.1\|WP_003806885.1\|4281645_4282179_-\|transcription-termination/antitermination-protein-NusG	unknown	unknown	gnl\|CDD\|180161
NZ_CP049918.1\|WP_003816064.1\|4295921_4296359_-\|tripartite-tricarboxylate-transporter-TctB-family-protein	unknown	unknown	gnl\|CDD\|377815
NZ_CP049918.1\|WP_003816055.1\|4300276_4301551_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340913
NZ_CP049918.1\|WP_003806886.1\|4281150_4281582_-\|50S-ribosomal-protein-L11	unknown	unknown	gnl\|CDD\|234661
NZ_CP049918.1\|WP_003806880.1\|4286548_4287355_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP049918.1\|WP_003816057.1\|4299038_4299719_-\|response-regulator	unknown	unknown	gnl\|CDD\|185376
NZ_CP049918.1\|WP_003816053.1\|4301495_4302848_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	unknown	unknown	gnl\|CDD\|235392
NZ_CP049918.1\|WP_003816050.1\|4302964_4304551_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173863
NZ_CP049918.1\|WP_003806884.1\|4282188_4282569_-\|preprotein-translocase-subunit-SecE	unknown	unknown	gnl\|CDD\|235587
NZ_CP049918.1\|WP_010929565.1\|4296463_4297468_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|225722
NZ_CP049918.1\|WP_033451488.1\|4288155_4288848_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	unknown	unknown	gnl\|CDD\|234637
NZ_CP049918.1\|WP_003806879.1\|4287361_4288159_-\|ParA-family-protein	unknown	unknown	gnl\|CDD\|379293

Protein	Function_ID	Function_description	E-value
NZ_CP049918.1\|WP_014906142.1\|4293159_4294326_+\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|181642	PRK09082, PRK09082, methionine aminotransferase; Validated.	0
NZ_CP049918.1\|WP_042145827.1\|4297588_4298965_-\|sensor-histidine-kinase	gnl\|CDD\|182388	PRK10337, PRK10337, sensor protein QseC; Provisional.	3.38823e-53
NZ_CP049918.1\|WP_033451346.1\|4284593_4285595_-\|asparaginase	gnl\|CDD\|199208	cd08964, L-asparaginase_II, Type II (periplasmic) bacterial L-asparaginase. Asparaginases (amidohydrolases, E.C. 3.5.1.1) are enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases. This model represents type II L-asparaginases, which tend to be highly specific for asparagine and localized to the periplasm. They are potent antileukemic agents and have been used in the treatment of acute lymphoblastic leukemia (ALL), but not without severe side effects. Tumor cells appear to have a heightened dependence on exogenous L-aspartate, and depleting their surroundings of L-aspartate may starve cancerous ALL cells. Type II L-asparaginase acts as a tetramer, which is actually a dimer of two tightly bound dimers. A conserved threonine residue is thought to supply the nucleophile hydroxy-group that attacks the amide bond. Many bacterial L-asparaginases have both L-asparagine and L-glutamine hydrolysis activities, to a different degree, and some of them are annotated as asparaginase/glutaminase.	3.2268e-128
NZ_CP049918.1\|WP_003806883.1\|4282807_4283998_-\|elongation-factor-Tu	gnl\|CDD\|234596	PRK00049, PRK00049, elongation factor Tu; Reviewed.	0
NZ_CP049918.1\|WP_003816068.1\|4292553_4292760_-\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.00961e-35
NZ_CP049918.1\|WP_003816065.1\|4294401_4295925_-\|tripartite-tricarboxylate-transporter-TctA	gnl\|CDD\|225870	COG3333, COG3333, Uncharacterized protein conserved in bacteria [Function unknown].	0
NZ_CP049918.1\|WP_003806881.1\|4285587_4286505_-\|ParB/RepB/Spo0J-family-partition-protein	gnl\|CDD\|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	3.93163e-80
NZ_CP049918.1\|WP_003806887.1\|4280449_4281148_-\|50S-ribosomal-protein-L1	gnl\|CDD\|180071	PRK05424, rplA, 50S ribosomal protein L1; Validated.	3.14793e-142
NZ_CP049918.1\|WP_003806885.1\|4281645_4282179_-\|transcription-termination/antitermination-protein-NusG	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	1.04532e-103
NZ_CP049918.1\|WP_003816064.1\|4295921_4296359_-\|tripartite-tricarboxylate-transporter-TctB-family-protein	gnl\|CDD\|377815	pfam07331, TctB, Tripartite tricarboxylate transporter TctB family. This family consists of several hypothetical bacterial proteins of around 150 residues in length. This family was formerly known as DUF1468.	2.97032e-07
NZ_CP049918.1\|WP_003816055.1\|4300276_4301551_+\|MFS-transporter	gnl\|CDD\|340913	cd17355, MFS_YcxA_like, MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters. This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.56725e-33
NZ_CP049918.1\|WP_003806886.1\|4281150_4281582_-\|50S-ribosomal-protein-L11	gnl\|CDD\|234661	PRK00140, rplK, 50S ribosomal protein L11; Validated.	3.95413e-93
NZ_CP049918.1\|WP_003806880.1\|4286548_4287355_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.85729e-10
NZ_CP049918.1\|WP_003816057.1\|4299038_4299719_-\|response-regulator	gnl\|CDD\|185376	PRK15479, PRK15479, transcriptional regulator TctD.	2.3231e-75
NZ_CP049918.1\|WP_003816053.1\|4301495_4302848_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	gnl\|CDD\|235392	PRK05291, trmE, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE.	0
NZ_CP049918.1\|WP_003816050.1\|4302964_4304551_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173863	cd08498, PBP2_NikA_DppA_OppA_like_2, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NZ_CP049918.1\|WP_003806884.1\|4282188_4282569_-\|preprotein-translocase-subunit-SecE	gnl\|CDD\|235587	PRK05740, secE, preprotein translocase subunit SecE; Reviewed.	2.94869e-31
NZ_CP049918.1\|WP_010929565.1\|4296463_4297468_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|225722	COG3181, COG3181, Uncharacterized protein conserved in bacteria [Function unknown].	3.55463e-94
NZ_CP049918.1\|WP_033451488.1\|4288155_4288848_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	gnl\|CDD\|234637	PRK00107, gidB, 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG.	1.9819e-75
NZ_CP049918.1\|WP_003806879.1\|4287361_4288159_-\|ParA-family-protein	gnl\|CDD\|379293	pfam13614, AAA_31, AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	1.37402e-85

>NZ_CP049918.1|WP_033451488.1|4288155_4288848_-|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG
MSAVPDIPGGPAQRLAQACDALRLQADAGQQQKLLRYIEQMQRWNRTYNLTAIRDPGQMLVQHLFDSLSVVAPLERGLPAAGSGARVKLFDVGSGGGLPGVVLAIMRAHWDVTCVDAVEKKTAFVRQMAGALGLPNLQAAHTRIEQLEPAQCDVVISRAFASLQDFAKLAGRHVREGGTLVAMKGKVPDDEIQALQQHGHWTVERIEPLVVPALDAQRCLIWMRRSQGNI
>NZ_CP049918.1|WP_003806879.1|4287361_4288159_-|ParA-family-protein
MKNIPPSKSARVFCIANQKGGVGKTTTAINLAAGLATHKQRVLLVDLDPQGNATMGSGIDKSTLESNLYQVLIGEAGIEQTRVRSESGGYDVLPANRELSGAEIDLVQMDERERQLKAAIDKIAGEYDFVLIDCPPTLSLLTLNGLAAAHGVIIPMQCEYFALEGLSDLVNTIKRVHRNINNELRVIGLLRVMFDPRMTLQQQVSAQLESHFGDKVFTTVVPRNVRLAEAPSYGMPGVVYDRASRGAQAYIAFGAEMIERVKELD
>NZ_CP049918.1|WP_003806880.1|4286548_4287355_-|GNAT-family-N-acetyltransferase
MPAVLAVPAAHPAPAAGGELARLEEAALNATTVREQMLYEGWLVRWAPSRAKRARCVNVLGLSTRPLDERLAYCTRWYAGHGVPLIVRLTSIGPDFSLDAQLHERGFVAFDRTCVMAASVVPFTAQAPSGLVFERTTPGRFAQEAGRLRGHDDAATAEHAARLQAAPLENLPLLVRDASGECIAAGLAAFDAELVGLFDIVTAPQRRRQGCGAAVLKYLLEQASHAGARQAYLQVEPQNTAARALYARFGFVDRYTYWYRSMSEATPV
>NZ_CP049918.1|WP_003806881.1|4285587_4286505_-|ParB/RepB/Spo0J-family-partition-protein
MATKKPKGLGRGLDALLGADVPAIDNIGKAPAAAPEGPPATLPVSKMRAGKYQPRTRMDEGALNELAESIRTQGIMQPILVRALGADAPGQYEIIAGERRFRAAQLAGLKEVPVLVREVADENAAVMALIENIQREDLNPLEEAHGVRRLLDEFGLTHEQAAQAIGRSRSATSNLLRLLNLAAPVQTMLLAGDVDMGHARALLAVDAATQIQLANQVIAKRLSVREAEKLVARAQKDVDAAPRKKGNGASRDVTRLEEALSDHLGTRVALKVGAREKGQIVIDFHGWEHLNSLLERQGLSGVVDA
>NZ_CP049918.1|WP_033451346.1|4284593_4285595_-|asparaginase
MPEARLPRIAVLATGGTIAGAQTDAASGAYRAGSYGVGQLLAAVPQLAGLARIGAEQIANVGSQNMSHAVWRQLALRAAALCDDPATDGIVITHGTDTLEETAYFLSLVLPVDKPVVLLGAMRPATALSADGPVNLYNAVALACHPAARGRGPLVVMNEDIHLARHVQKTAASGIAAFASPNAGRAGVMQGGRPVFHARAERQAADALLRPDELPQHAWPRVDIVHACVDLDGELIDFMAGRAQGIVLAGVGDGNATDAALQALQRASARGVAVVRASRTGSGRVGRNIEIDDDACGFIAAGDLSPQKARVLLTLGLCQTRDTARLQALFDSR
>NZ_CP049918.1|WP_003806883.1|4282807_4283998_-|elongation-factor-Tu
MAKGKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLSNKFGGEARGYDQIDAAPEEKARGITINTSHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLSRQVGVPYIIVFLNKADMVDDAELLELVEMEVRELLSKYDFPGDDTPIVKGSAKLALEGDKGELGEQAILSLAQALDTYIPTPERAVDGAFLMPVEDVFSISGRGTVVTGRIERGVVKVGEEIEIVGIKPTVKTTCTGVEMFRKLLDQGQAGDNVGILLRGTKREDVERGQVLAKPGSINPHTDFTAEVYILSKEEGGRHTPFFNGYRPQFYFRTTDVTGTIDLPADKEMVLPGDNVSMTVKLLAPIAMEEGLRFAIREGGRTVGAGVVAKIIK
>NZ_CP049918.1|WP_003806884.1|4282188_4282569_-|preprotein-translocase-subunit-SecE
MSNTSIETVTSTADRIKLGLAVLVVIAGIVGFSMLDAQPMVARIGVFVGGLVVAALLAWFSEPGRRTLSFAGESYNEVKRVSWPTRKETIQMTGIVFAFVAVMGLLMWVLDKGIEWVLYGLLLGWK
>NZ_CP049918.1|WP_003806885.1|4281645_4282179_-|transcription-termination/antitermination-protein-NusG
MSKRWYVVHVYSGMEKSVQKALNERIERAELQTSFGRILVPSEEVVEVKGGQKSITERRIFPGYVLVEMDLTDETWHLVKNTNRVTGFLGGSGNRPTPISEREVEKILNQMEEGVEKPRPKILFEVGEMVRVKEGPFADFNGNVEEVNYEKSKVRVSVTIFGRATPVELDFSQVEKT
>NZ_CP049918.1|WP_003806886.1|4281150_4281582_-|50S-ribosomal-protein-L11
MAKKIVGFIKLQVPAGKANPSPPIGPALGQRGLNIMEFCKAFNAKTQGMEPGLPIPVVITAFADKSFTFIMKTPPATVLIKKASGVQKGSAKPHTDKVGTLTRAQAEEIAKTKQPDLTAADLDAAVRTIAGSARSMGITVEGV
>NZ_CP049918.1|WP_003806887.1|4280449_4281148_-|50S-ribosomal-protein-L1
MAKLSKRAAAIAQKIDRTKLYPVGEALNLVKETATAKFDESIDVAVQLGIDPKKSDQLVRGSVVLPAGTGKTVRVAVFAQGEKADAARAAGADIVGLDDLAEQIKAGQMDFDVVIASPDTMRVVGALGQVLGPRGLMPNPKVGTVTPDVATAVKNAKAGQIQYRTDKAGIIHATIGRASFGVEQLQNNLAALVDALQKARPAAAKGIYLRKLAVSSTMGGGARVEIASLSAN
>NZ_CP049918.1|WP_003816068.1|4292553_4292760_-|cold-shock-protein
MAQKGKVKWFNADKGYGFITPDSGGTDVFAHFSAIQGRGYRSLNEGQEVEFEVKDGPKGPQAAEIRPL
>NZ_CP049918.1|WP_014906142.1|4293159_4294326_+|pyridoxal-phosphate-dependent-aminotransferase
MIRSKLPDVGTTIFTVMSRLAIEHKAINLGQGFPDFDPDPELCALVGKAMAAGHNQYPYMPGVAPLREAIAAKVKTLYGHAYDPETEITVTSGATEALMATVLAAVGPGDEVVVIEPCYDSYLPAIRLAGGTAVPVPLRAPTRDDPYYRIDWQRVRDAIGARTRLLMLNFPHNPTGAVLDESDLDALESIVRETGVLLLSDEVYEHIVFDGKPHASLSRRPLLAEHAFVISSFGKTYHTTGWKVGYCCAPRQLSAELRKVHQFMVFTVSSPMQFALAEYMANPKPYLDLPAFYQAKRDRLAAGLANTRFRPLPSPGTFFMLADYSEITKHAEADFARHLTIDHGVTVIPVSAFYQNPAAPESNHHLVRFCFAKQDATLDAAIERLAHV
>NZ_CP049918.1|WP_003816065.1|4294401_4295925_-|tripartite-tricarboxylate-transporter-TctA
MSGILDHLAIGFGVAFSLTNVLVAAIGSFFGTMVGVLPGLGPINGVAMLIPIAFAMNLPPETALILLAAVYVGAEYGGRITSILLNVPGEASAIMTTLDGYPLARQGLANVALSLSAWSAFFGAIVSVTGIILLAPLLAKWALAFGPAEYFVLMVFAFCCLTSLLGKQPVKGVLAAMIGLGISVVGVDSNSGVYRYTFDSVHLSDGIDFVVVVIALFAVSEMLEMLEKVVAGHSIEVKPSGRKLFNLKELSFTWWSVVRSSLVGFGVGVLPGAGASVAAAVAYSQEKRIIESKDPDAKFGKGDMRGLVAPESAATASAIGSFVPMLTLGVPGSGTTAVMMGALTLYNITPGPVLFDSKPELVWGLIASLFIANVLLFIMNVPMVRVFSKVLAVPAWMMVPGILCISYIGVYAINAGTFDLLMVVAIGALGYFLRKFGVPMAPLVLGVVLGDMMEQNLRRALSITNGDPVVLYSSPVSIGLWIAAAAVVIVPQLMRRLSARRRQAAQS
>NZ_CP049918.1|WP_003816064.1|4295921_4296359_-|tripartite-tricarboxylate-transporter-TctB-family-protein
MNDRMLGVFALILAAFMTWAGWDIEAPFAYEPVGPRAFPMLVALIIGLCGLRLVYKGGHQVETNSAGANARIALMVAYAAAYAFLFQWLGFVIATALMTVAVGRLFGGNWIKCAIGGLIMGVLFFLLFDKVLDVVLPAGLLEGLL
>NZ_CP049918.1|WP_010929565.1|4296463_4297468_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MHTLAKFRATAAALAGLCALFIGNAAHAASDEPRRPECIAPAQPGGGFDLTCRLATEGLKQSGALKAPMRIVYMPGGIGAVAYNNIVAQHPGEAGTIVAFSGGSLLNLAQGKFGKYSVDDVRWLAGIGADYGVAVVRNDSPYTDLKGLMEAFKQDPTKIVLGAGGTVGSQDWMKAALTAKAAGVDFKKMRFVAFEGGGEAVTALRGGHIQAYMGDAAEAFTMLEGGAPIRVLAVFNSERLPGKLNNVPTAKEQGYDIVWPIIRGFYVGPKVSDKDYQFWVDAFDKTMTSPEYAKLREQQGLFPFSKTGKDLDDYVKQQVKNYAELADSFGLIKK
>NZ_CP049918.1|WP_042145827.1|4297588_4298965_-|sensor-histidine-kinase
MTGALWLSNQQLRNQVDIAYDRSLSGALRSIDHNISTASGGLSLEQPYLMLEFFELTANGNVYYRVATEDGLAEIGNPQLPLPPQPLVSGQPQFFYAEYLGQPVRVAALARPMDPPLYNDKGGRIIVQVAESLETRQDFLHRALVRSVERDLAVVMISVLVVIWSVFMALRPLERLREEVASRSADDLSPVSASEMPGEVQPLIHAVNLHMARFTALARVQRQFLDDASHQLRTPLSVLRTQTAYALRETDPQEVRTALLAMQDGLDRAVRTTNQMLALARAKDASLAEGGLPLETVDLAELADGVIRALLPAARARQLDLGLDVQAAPVRVQAVEWLLREALSNLVDNAIRYTARGSEVTVKVHAEGGHAWLVVEDNGPGMSAEDIARASVRFRRGAAGKNKSGAGLGLAIVRTIIEIHGGQLVLENRQPQPGLRAALVFSLGFKGNAALPHEIVVI
>NZ_CP049918.1|WP_003816057.1|4299038_4299719_-|response-regulator
MRILLIEDEAELARWLSRSLARHAGFVVEWADDGLLAERRLAVEEFDAIILDLGLPGMDGHTLLTRIRARDDRTPVLVLTARDSLAERVGTLHQGADDFLPKPFVLEELEARLTALIRRSRGREHPRLTLGDLALDTASQRFTVKGQPLALSPREHAVLRALIQRSGEPLNKQQILDRIQSSDSDVNLEAIEVLVHRLRKKLADTGVQIVTMRGMGYCLENAVDNP
>NZ_CP049918.1|WP_003816055.1|4300276_4301551_+|MFS-transporter
MTRHSTPFAGRQVLAASFVMAIYGWGMGFYGPPVFLHAVVERTGWPLQWVAGMVTLHFVAGALAVANLRRLYRLAGIPMVTFCGALGSALGTFGWAVAATPWQLAIAALVSGASWAALGAAAINALIEPWFVVRRPAALGMAYNGASVGGIVFSPLWALLIQAWGFAWAAGVVGASMVLVIAVLASLVFTRTPANTGQAPDGEAVAPRPAANPAPPARPAGRLREDRRFVTLAAAMSLGLFAQMGLVAHLYSLLVPTLGPGTAGLAMGAATGCAIAGRTIVGRIAGAGSDRRLLASHAYAIQALGALLLLAAGDTPALVWLGLLLFGSGIGNATSLPPLIAQNEFDPASVRRVVPLIVALSQAAYAFAPAVFGMLRGVSDAASAPWLFVAAAALQAAAIACLLAGRATCRCRNSKRSRPASRRW
>NZ_CP049918.1|WP_003816053.1|4301495_4302848_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE
MSLYAPIAAIATAPGRGGIGVVRISGPDLAELAQRLFGRPLTPRHAHYLPFRAADGEVIDEGLAIYFRAPHSYTGEDVLELQGHGGPAVLRRILARCLQAGHDLGLRPAEPGEFTRRAFLNERLDLAQAEAVADLIDASSEAAARGAMASLSGEFSQRVNDLSDRIIHLRMLVEATLDFPEEEIDFLEKYQARPTLQALTHDLDTLIAQARQGVILREGLHVVLAGKPNVGKSSLLNALAGDDIAIVTPIAGTTRDKVVQEIHIDGVPLHIVDTAGLRDTDDAVESIGIERTWKEIERADLILHLQDVTQPPDHLDAQIVRRLPARTPVLNVFNKVDLLDAAFQGRPDSLAISARGGIGLDALRQRLLQLAGWNPGAESPWLARERHLHALQQAAQHLEIATEHAREDDRVLDLFAEELRLAHEALTGITGKFTSDDLLGEIFSSFCIGK
>NZ_CP049918.1|WP_003816050.1|4302964_4304551_+|ABC-transporter-substrate-binding-protein
MISRLSRVVTCGSVIVALALGGASAALARDLVVALKTEPSSMDPQYHALTPNTQISQTIFDPIVRVDEQLKPQPALAESWTVDGKVWTFKLRPDVKFSDGTPFTAEDVVFTYDRIPKVPNSPSPFTLYLGAVAKTEAVDPLTVRITTKDVTPLLLVNLAQLPIMSKKAASGPAPEGKTTTELNSGNGLIGTGPYKFVSWKRGAEFVLARNENYWGKPPAWDKVTYRPMTNAAARVAALLAGDVDMIEDPPTDDLPKLKADKKLYVEETPSVRVVYLALDQYAEPSPGVQGTDKNPMKDKRVREALSLALNRDAIVDRVMGGVAKPAGNLLPYPMFGSSKEHSQAPKADVEKAKALLKEAGYPNGFSITLGSPSGRYVNDAKVAQAIASMWTRIGVKTSVDSMAPPVFFKNRDSYAFSAYLAGWSVTSGEMSNALTSLLVTRNPEAGLGTTNRSRYSNPAMDELVKQASSTMDDAKRAELLQKASNLAMDDYAMLPVHFELSVWAMKNDIRYTGRPDQTTLVQYATVKK

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Crispr_ID: NZ_CP049918_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049918_8

5080159-5080252

Orphan

Consensus_repeat	Method
GTGCCTGTCCCGGCGGGGACAGGCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049918_8

>merge|NZ_CP049918|8|5080159-5080252|CRISPRCasFinder
GTGCCTGTCCCGGCGGGGACAGGCACGCCCGCACAGCGGGCGCAGCGTGGGGGTTTTCCTGGGCCCGGGTGCCTGTCCCGGCGGGGACAGGCAC

>NZ_CP049918|8|7|5080159-5080252|CRISPRCasFinder
GTGCCTGTCCCGGCGGGGACAGGCAC	GCCCGCACAGCGGGCGCAGCGTGGGGGTTTTCCTGGGCCCGG
GTGCCTGTCCCGGCGGGGACAGGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049918.1\|WP_003814681.1\|5087241_5088219_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176106
NZ_CP049918.1\|WP_003814701.1\|5079601_5080072_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP049918.1\|WP_003814694.1\|5083231_5083987_+\|TerC-family-protein	unknown	unknown	gnl\|CDD\|223930
NZ_CP049918.1\|WP_003814678.1\|5088344_5089517_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173841
NZ_CP049918.1\|WP_003814711.1\|5074435_5074891_+\|multidrug/biocide-efflux-PACE-transporter	unknown	unknown	gnl\|CDD\|226610
NZ_CP049918.1\|WP_042962164.1\|5073107_5073503_-\|GtrA-family-protein	unknown	unknown	gnl\|CDD\|377229
NZ_CP049918.1\|WP_010929253.1\|5090637_5091831_+\|acetyl-CoA-C-acyltransferase	unknown	unknown	gnl\|CDD\|180775
NZ_CP049918.1\|WP_003820700.1\|5079168_5079513_+\|TIGR01244-family-phosphatase	unknown	unknown	gnl\|CDD\|225984
NZ_CP049918.1\|WP_010927086.1\|5071528_5073148_+\|glycosyltransferase-family-39-protein	unknown	unknown	gnl\|CDD\|224720
NZ_CP049918.1\|WP_033446464.1\|5077623_5079069_+\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP049918.1\|WP_003814709.1\|5074896_5075820_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|378820
NZ_CP049918.1\|WP_003814699.1\|5080482_5082606_+\|elongation-factor-G	unknown	unknown	gnl\|CDD\|234569
NZ_CP049918.1\|WP_003814691.1\|5084182_5085415_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NZ_CP049918.1\|WP_003814706.1\|5076565_5077480_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NZ_CP049918.1\|WP_003814689.1\|5085407_5086193_+\|crotonase/enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl\|CDD\|181723
NZ_CP049918.1\|WP_010927085.1\|5075909_5076569_-\|LysE-family-translocator	unknown	unknown	gnl\|CDD\|224199
NZ_CP049918.1\|WP_003814697.1\|5082602_5083121_-\|MgtC/SapB-family-protein	unknown	unknown	gnl\|CDD\|224204
NZ_CP049918.1\|WP_165646047.1\|5089543_5090572_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|366103
NZ_CP049918.1\|WP_003814685.1\|5086259_5087231_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP049918.1\|WP_162835034.1\|5073437_5074439_+\|ChbG/HpnK-family-deacetylase	unknown	unknown	gnl\|CDD\|212118

Protein	Function_ID	Function_description	E-value
NZ_CP049918.1\|WP_003814681.1\|5087241_5088219_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176106	cd08414, PBP2_LTTR_aromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LTTRs involved in degradation of aromatic compounds, such as CbnR, BenM, CatM, ClcR and TfdR, as well as that of other transcriptional regulators clustered together in phylogenetic trees, including XapR, HcaR, MprR, IlvR, BudR, AlsR, LysR, and OccR. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	2.33368e-60
NZ_CP049918.1\|WP_003814701.1\|5079601_5080072_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	9.38587e-30
NZ_CP049918.1\|WP_003814694.1\|5083231_5083987_+\|TerC-family-protein	gnl\|CDD\|223930	COG0861, TerC, Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism].	1.14565e-78
NZ_CP049918.1\|WP_003814678.1\|5088344_5089517_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	6.87275e-84
NZ_CP049918.1\|WP_003814711.1\|5074435_5074891_+\|multidrug/biocide-efflux-PACE-transporter	gnl\|CDD\|226610	COG4125, COG4125, Predicted membrane protein [Function unknown].	2.35069e-54
NZ_CP049918.1\|WP_042962164.1\|5073107_5073503_-\|GtrA-family-protein	gnl\|CDD\|377229	pfam04138, GtrA, GtrA-like protein. Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.	8.84202e-15
NZ_CP049918.1\|WP_010929253.1\|5090637_5091831_+\|acetyl-CoA-C-acyltransferase	gnl\|CDD\|180775	PRK06954, PRK06954, acetyl-CoA C-acetyltransferase.	2.86943e-175
NZ_CP049918.1\|WP_003820700.1\|5079168_5079513_+\|TIGR01244-family-phosphatase	gnl\|CDD\|225984	COG3453, COG3453, Uncharacterized protein conserved in bacteria [Function unknown].	3.40043e-35
NZ_CP049918.1\|WP_010927086.1\|5071528_5073148_+\|glycosyltransferase-family-39-protein	gnl\|CDD\|224720	COG1807, ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane].	1.9702e-50
NZ_CP049918.1\|WP_033446464.1\|5077623_5079069_+\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	6.70342e-111
NZ_CP049918.1\|WP_003814709.1\|5074896_5075820_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|378820	pfam12146, Hydrolase_4, Serine aminopeptidase, S33. This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.	2.97616e-21
NZ_CP049918.1\|WP_003814699.1\|5080482_5082606_+\|elongation-factor-G	gnl\|CDD\|234569	PRK00007, PRK00007, elongation factor G; Reviewed.	0
NZ_CP049918.1\|WP_003814691.1\|5084182_5085415_+\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	8.36236e-118
NZ_CP049918.1\|WP_003814706.1\|5076565_5077480_-\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	8.05606e-10
NZ_CP049918.1\|WP_003814689.1\|5085407_5086193_+\|crotonase/enoyl-CoA-hydratase-family-protein	gnl\|CDD\|181723	PRK09245, PRK09245, crotonase/enoyl-CoA hydratase family protein.	2.06175e-156
NZ_CP049918.1\|WP_010927085.1\|5075909_5076569_-\|LysE-family-translocator	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	4.25651e-32
NZ_CP049918.1\|WP_003814697.1\|5082602_5083121_-\|MgtC/SapB-family-protein	gnl\|CDD\|224204	COG1285, SapB, Uncharacterized membrane protein [Function unknown].	1.52093e-44
NZ_CP049918.1\|WP_165646047.1\|5089543_5090572_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|366103	pfam00441, Acyl-CoA_dh_1, Acyl-CoA dehydrogenase, C-terminal domain. C-terminal domain of Acyl-CoA dehydrogenase is an all-alpha, four helical up-and-down bundle.	1.31947e-12
NZ_CP049918.1\|WP_003814685.1\|5086259_5087231_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	2.06741e-117
NZ_CP049918.1\|WP_162835034.1\|5073437_5074439_+\|ChbG/HpnK-family-deacetylase	gnl\|CDD\|212118	cd10807, YdjC_like_3, uncharacterized YdjC-like family proteins from bacteria. This subfamily contains many hypothetical proteins, and belongs to the YdjC-like family of uncharacterized proteins from bacteria. The YdjC-family is represented by an uncharacterised protein YdjC (also known as ChbG) encoded by the chb (N,N'-diacetylchitobiose, also called [GlcNAc]2) or cel operon in Escherichia coli, which encodes enzymes involved in growth on an N,N'-diacetylchitobiose carbon source. The molecular function of this subfamily is unclear.	1.99725e-92

>NZ_CP049918.1|WP_003814701.1|5079601_5080072_+|universal-stress-protein
MFKKILIPTDGSPLSAQAANAGICFARSTGAEVVALHVTQPFAATIGFDGMAAAYAITDEDYEKASAEQAEKYLKLILDRAETAGVKAESRAVSNFNVADGIVQAAGEAGCDLIFIGSHGRSGLSRLLLGSVTAKVLSLAHTAVLVYRVKEDKDKK
>NZ_CP049918.1|WP_003820700.1|5079168_5079513_+|TIGR01244-family-phosphatase
MSAAIKPLTENFAVAPQLGPADMADVAAAGYKSVIINRPDFEGGPDQPTAADVSQAAQALGLQVEYQPVVGSAMTAADVARFAELLRTMPGPVLAYCRTGTRCTNLFAAAQQLG
>NZ_CP049918.1|WP_033446464.1|5077623_5079069_+|PLP-dependent-aminotransferase-family-protein
MTVATSSPSGAGWQPVRQADATLVTQLADDLARRIDEHGLRPGTRLPSIRRMAEQSGVSRFTVVEAYDRLVARGLVQSRRGAGFFVRARSASLTALASARVPQAAPETPVRVDVSWLLRNMFRETAAGMPGGAGLLPPEWLDPDMVAAAVRAVGRTVRGNLVSYGSPQGYAPLRQQLASMLQADGVPAHPERNLLTTNGVTHGLDIVARHLIKPGDTVLVEDPAWFVIFGRLAAFGARPVGVPRGPDGPDLAMLDRLAAEHKPRLYIINGAVHNPTGHTLSAGAAYDILRLAERHDFMVVEDDTYADLHPGGAMKLAALDRLERVILVGGFSKMLAASLRVGYIAAGAETLQRLTDLKMLAGLTSPELGERVVHRVLVEGQYRRHIERVRARVNEARLRSIQALQQLGLSVPHEPHAGMFVWADCGRDSEPVARNAAERGMLLAPGTLFSPSGAPSTMLRFSVAMVDTPGIWQSIAAVMAQ
>NZ_CP049918.1|WP_003814706.1|5076565_5077480_-|DMT-family-transporter
MSPPSAQASAPSASPHAPSWEGYGYGLIGVLVFALTLPMTRLAVGELSPLLVGLGRALLAAVPAAALLWLTRSRRPDRAEWSGIVLAAVGIVVGWPVASTLAMASVPAAHGAVFNGLLPLSTAVFAAWRSGERPSPAFWSFAVLGAVLVAGYALRQGHGALQPGDLWLLLAVVLGGMGYAEGARASRTLGGWRTICWALVVSVPALLPAVLWLAHDAAWPSLPVAGAFAYLAFGSMFLGFFAWYRGLAIGGIARVGQIQLLQPFLTVVAAALLFNEQVEPITYVFAVAVVLVIAGGRRAMVRKA
>NZ_CP049918.1|WP_010927085.1|5075909_5076569_-|LysE-family-translocator
MIGSDLSSLDQAPLASLSVLMPLVLFTLVNSLTPGPNNVMLASSGLTFGFRRTIPHLLGISVGFSIMLLMVGLGLGATLERLPWLYSTLKYGGAAYLLYLAWKIATSGPMESGAERGKPLTFIQAALFQWVNPKAWVMIVSVVATYTPQHGYFANLIIATLVCGVVNLPSVGVWAAFGMALRRWLHRPAAVRAFNVGMAVLLVVSLYPVGLDLLALYTG
>NZ_CP049918.1|WP_003814709.1|5074896_5075820_-|alpha/beta-fold-hydrolase
MVSLPFRLSWRRMAAVLLLAAGALGFNQLDAWQRQAIFSPQTDQQRWWREPPAGTEVFDLALPNGDKVHAWYWQSPRRDAPTVLYLHGARWNLNGSAFRMEGWTRMGYSMLAIDYRGFGQSTPLLPSEQSASQDAAAALQELARRQPDPARRFIYGHSLGGAIAIDLAARPDLPPFAGLIVESSFTSIGAMLGTMKWGWVPGATLLVTQPFASVDKLAALTTPMLLLHGTADRVVPHTMSDELYRAAQQVPADLKRLVKIEGASHSGAIRSGRIYEDAVADFVRDAGRGYAGRQGAPTPLTASRPGT
>NZ_CP049918.1|WP_003814711.1|5074435_5074891_+|multidrug/biocide-efflux-PACE-transporter
MSSSSKQTPKTIKERFLHAFFFEIIAIGLSAPVAAWAMDQPLFDMGVLTAVIAWIALLWNMVYNAGFERLERRFGVVRTMPVRVAHAVGFELGLVLIIVPLAAWWLAISFWEAFMLDIGLLMFYLPYAFFYNLAYDKLRARWWGRIEPAGA
>NZ_CP049918.1|WP_162835034.1|5073437_5074439_+|ChbG/HpnK-family-deacetylase
MGGGRGASDGNEPGNLSQQAAHVEEVSPLRNQAGDVRCRRIAVCGDDFGMNEAIDGALIELAGAGRLSAVSCMPLAPAFAADAPALARLDVDLGVHVDFTEAFAGAAPAAPGLAALLWRAYAGQLDPDWIDARLASQFDAFERAFGRAPDYVDGHQHVHQLPGILPRLRALLKRRYAGQRIWLRHTAPGLQFGLPLAEAAKARLIGALGAGALARAAGQEGWQTNRRMLGVYGFTGGPRRYAGLLHHWLMNARDGDLLMCHPGWPQVHGAAHASQRAAEYEVLAHPELGTWLARNGLRIVRLSQVRGRQASQESGKVRNVPHSGSFRRLASRL
>NZ_CP049918.1|WP_042962164.1|5073107_5073503_-|GtrA-family-protein
MRGLLRQIAWFIAVGCAAAATHWAVAVACVEWAGLPPLGANVVGWLLAFVVSFTGHFRLTFRHLAASWTIAARRFFLVSALGFAINELSYAWLLHATSLPYDVLLALVLIGLAFLTFVASRLWAFRHRHAP
>NZ_CP049918.1|WP_010927086.1|5071528_5073148_+|glycosyltransferase-family-39-protein
MTLATRSMQPHAVSPGQARSWPLPAAGWLLLAVGVWLAFLSWMRPLALPDEGRYAGVAWDMLRNGSFAVPLIDGMPYFHKPPLYYWLAELSFRLFGVNEWAARLPSALAAWASAVALYLFVRRHRDAASATLCVLVLATLPLFFGGAQYANMDMLVAGMITLCVLAGADTALRVRGGQAWRAMALATGVCAALAMLAKGLIGLVLPGAILLAWLAWRRDWRGLRALLWPPAILAFAVVAVPWFWLMQVRYPGFFQYFFVHQHFERFAQTGFNNVQPFWFYLPVIAGLALPWSLWAGGLLRKQFWAADADPDGLRRLALVWLAVIVAFFSMPQSKLVGYIMPVLPPLAFLLAEVVMGALRDPAVARATRRMARVSALVAVAICVTAVFVASFNARGSSRELALSLRGELRPDDTLVALHTYPFDLQLYAHAARPMWVVDDWSNPEIPKRDNWRRELYDAVQFEPALGERLLVSADTFQQRLCQAPEGSRYWVWGTAADEEAYAPLRGQAARFADARRSLWLVLVDEAFKGRVCDGTPTGG
>NZ_CP049918.1|WP_003814699.1|5080482_5082606_+|elongation-factor-G
MTRRTSIERYRNIGISAHIDAGKTTTTERILFYTGITHKLGEVHEGAATMDWMEQEQERGITITSAATTAFWRGMAGNYPEHRINIIDTPGHVDFTIEVERSMRVLDGACMVYDSVGGVQPQSETVWRQANKYGVPRIAFVNKMDRVGADFFRVQRQIVERLKGDAVPIQIPVGAEDHFEGVVDLVKMKAIIWDDASQGVRFEYRDIPPELQAQAEQWREKMIEKAAEANEALLEKYLSGQPLSEDEIKSGLRARTVANEIVPMLCGSAFKNKGVQAMLDAVIDYLPSPADVPAIIGHDERDREIERHPADDEPFSALAFKIMTDPFVGQLVFFRVYSGVVKSGDSVLNPLKSKKERLGRILQMHANERREISEVYAGDIAAAVGIKEITTGDTLTDPAHVIILERMTFPEPVISQAVEPRTKADQEKMGIALNRLAQEDPSFRVRTDEESGQTIISGMGELHLEILVDRMKREFGVEANVGKPQVAYRETIRSTVTDVEGKFVKQSGGRGQYGHVVLKLEPQEQGKGYEFVDAIKGGVVPREFIPAVDRGVRETLNTGVLAGYPVVDVKVTLVFGSYHDVDSNENAFRMAASMAFKEGMRRAKPVLLEPMMHVEVETPEDFTGNVMGDLSSRRGMVQGMEDIAGGGGKLVRAEVPLAEMFGYSTSLRSLTQGRATYSMEFKHYAEAPRQVAEQIIAARGSGAAARG
>NZ_CP049918.1|WP_003814697.1|5082602_5083121_-|MgtC/SapB-family-protein
MDTVWMEIWTTVRNEFADIPDVAEATRIVLRLGMAVALGGLLGYERERSGKAAGLRTHMLVALGAALFVLVPLQGGMEVGDLSRVLQGVIAGIGFLGAGAIIKLGNEGEIRGLTTSAGIWLTAAIGVAAGMGREATALASTLIALFVLAALRRLEKRIAARDDKRVVAQPPP
>NZ_CP049918.1|WP_003814694.1|5083231_5083987_+|TerC-family-protein
MDYLVSLAQQPAAWAALATLIAMEVVLGIDNLIFISILTNKLPPQHQTKARRIGIGMALILRLALLGTVAFIVQLTQPVFELFGHGFSWRDVILVAGGLFLVWKATKEIHHHVDPNPGDDMFGGKAATLGFAAAVAQILMLDLVFSIDSIITAVGMTEHIPIMFVAVIVAVAVMLLAAEPLARFIERNPTVVMLALAFLMMIGMTLIAEGFGAHVPKGYIYAAMAFSALVEGLNMMARRAREGRGAGAAGG
>NZ_CP049918.1|WP_003814691.1|5084182_5085415_+|CoA-transferase
MSGPLEGVRILDVTTVLMGPYATQILGDLGADVIKVEPPAGDNVRGIGPGRHADMGGIFLHANRSKRSIALDLKNPAGREALLKVAATCDVLVYNVRPQAMARLGLSYAEVAQANPSILYVGMYGYDQRGPYAARAAYDDLIQGAVGIPSLSVEAGSDIPRYAPSAMVDRIVGISAANAVTAGLYHRARTGQGQAIDVPMFETMAHLILGDHMMGQTFEPPLGPPGYPRILNADRRPYATRNGHICVLLYADKHWKAFFELIGQPGRDAADPRFRDIGTRTQHIHAIYRLVSDAIASRTTEEWLAAFEAADIPAMPVHTMASLLRDPHLEAIGFFGMVDHPSEGAVRMMAVPSRWSGTPPQPRGHAPRLGEHSVDVLKEAGYDDEAIAALVRNGAAIAAARQLPEGTDHD
>NZ_CP049918.1|WP_003814689.1|5085407_5086193_+|crotonase/enoyl-CoA-hydratase-family-protein
MTDFLRHERHGGVLLLTMDRERTRNALSDADAVEALVQACARIGADLSVRAVVLTGSHGVFSSGGNLKTLSDTVGAGLGEPVHSRQAYRSGIQRIPLALYNLEVPTIAAVNGPAIGAGCDLACMCDIRLAARQASFAESFVKLGLTPGDGGAWLLPRIVGMSRACELAFTGRSIDAARARELGLVSEVFDADALLPAALALAQEIAQHSGHALRLTKRLLREGQHTRLDTLLELSAGFQALAHHTQEHAGALDAHLSRKRG
>NZ_CP049918.1|WP_003814685.1|5086259_5087231_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MHSRTLALALLSVAALAQGGSARAASDYPAHPVKIIVSLPPGSGADTTARFLSKHLAERFKQPFVVENRPGGNSFIAAQAVATAPPDGYTLFVASNSPMTTNAAVFKNLPYDAVKDFAPVAPIARFPMALVVPANSPYRSVADLVAAARAAPGQLNFASGTATYQVVLELFHEQNGIKATHVPYKGTSAALADVAGGVVQYSVADVSAALPLIRGGKLRPLAVTSTRRIKDLPDVPTMQESGNKGFEAYAWTAAFFPAKVDPAIVARVSDAVQALVRSQEGKAFMEQLGGEPFVGGPDTLAAFQRDELASMRRIAKLANIQQE
>NZ_CP049918.1|WP_003814681.1|5087241_5088219_-|LysR-family-transcriptional-regulator
MWTGQYIVHIASPAHHWRRAVELRQLKQLLVLSETLNFHRAAERLHMAQPPLSTAIKKLEQELGVQLFERLPAGLQPTPAAEVVLRYARATLFYADEIQRAAQEGASGKQGMLKVGFVGSSIYSLMPQLLSAFRKDYPRVDLVIEESTTVDLLRRLDAHTLDVALVRFPVLEPSTARITLLQADHLMLAVPAGSRYAQRDDVALDELADEPFIGYSRTHVPGMHALIMYAFQQYGVVPHIAQEAIQVQTILSLVESGLGLAIVPKVACRQAGSGVRLVNVPQLAETIKVGIALAVHPDNATPTTANFVDMACRLMQTEPAAGQAR
>NZ_CP049918.1|WP_003814678.1|5088344_5089517_+|acyl-CoA-dehydrogenase
MGAILGTIIEALQLAAIPAHDEALRPAVRAFLDEALREMPADRRARSWMGHDAEFSRALARQGWLGLTLPVEYGGAGRSNFARFVLSEELLAAGAPVSAHWIADRQTAPLILRFGSPAQRAFYLPRIIRGEAFFAIGMSEPDTGSDLASVRTRATPVADGWLLNGRKIWTTNAHRSHYMCALVRTSGAPEDRHRGLSQMIFDLALPGIEIRPIRDIAGDAHFCEVLFDNVLLPHDALVGEEGSGWRQVMAELALERSGPERIYSSMVLLDGWLAHLRRDAAPQRAQVCLAGRLAARLAVLRSMSLAVSQRLEQGADASLAAVLVKDLGTEFEQAVPELIGQALHASPQPAPDDVLMRTLAYLTLINPTFSLRGGTRHILRGIIARELGLR
>NZ_CP049918.1|WP_165646047.1|5089543_5090572_+|acyl-CoA-dehydrogenase
MVSTMQQDLYETFARALAGLCPLERVRELEAAADPRAGAARAWNEVDALGYGDALSPAEHGGAGLSLADAEGLLRAAGAMALPFPFADTLLARALLRAAGQAVPDGPIALGVALPHGAGWRCAPIAGVALAQAVAVEHDGCLALWPAPDAVQSGLFRPRASGAPAWRGTPAQAGRAGAPAGAVQAWRNAADAAGMAGAMQAVLDRCVAYVQERQQFGRALGRFQAVQQDISMLAEQVAAVAMAARLACASGALFPDPALAACARLRACEAVPVVCALAHAVHGAIGITEELPLGLYTARLHEWRATGMSEDDCAELLGRRVLADGERTLLDVVRGMVSAAHA
>NZ_CP049918.1|WP_010929253.1|5090637_5091831_+|acetyl-CoA-C-acyltransferase
MSVHPDPVVIVAARRTPIGAFQGALAHYSAPQLGAHALAAAVRQAGLQPDAAQEALMGCCLFAGLGQAPARQAVLGAGLPTDVQATTLSKMCGSGMKAAMLAHDMLRAGSADVVLAGGMESMSNAPHLIPKARQGYRLGDGQLLDHMYRDGLQDAYEGRLMGHYADLAAREYGFSREQQDAYAHESVLRAQRSVAEGEFAEEIAPIAGLARRGAPAAMVAVDETPGLCDVSRLASLKPVFNADGTVTAGNASSISDGAAALVLTRQAHAERLGLAPQARIVGHATAALPPGQFPAAPVRAIARLFERVGWDRDSVDLFEINEAFAVVTMIALRELGLPAERVNVNGGACALGHPVGATGARLIVTLMHALRRRGLRRGVACLCLGGGEATAIAIERA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1966213 : 1974279

uncultured_Mediterranean_phage(28.57%)

tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003811022.1\|1966213_1967098_-	peptidoglycan DD-metalloendopeptidase family protein	A0A292GJG6	Xanthomonas_phage	4.6e-15	49.5
WP_010928874.1\|1967115_1967895_-	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	4.8e-32	46.9
WP_003811017.1\|1967879_1968638_-	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	6.2e-69	51.2
WP_023852762.1\|1968775_1969411_+	glycerol-3-phosphate 1-O-acyltransferase PlsY	NA	NA	NA	NA
WP_003811013.1\|1969455_1970496_-\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	9.3e-92	51.6
WP_003811011.1\|1970630_1971923_+	NCS2 family permease	A0A0R6PHV4	Moraxella_phage	1.7e-66	36.0
WP_003811009.1\|1972128_1973154_+	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_003811007.1\|1973289_1973673_+	thioredoxin family protein	V9SJ74	Achromobacter_phage	8.1e-09	25.8
WP_003811006.1\|1973691_1974279_-	YigZ family protein	A0A1X9I5T8	Streptococcus_phage	2.1e-16	46.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP049918

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection