CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP049935	Phycicoccus sp. HDW14 chromosome, complete genome	10 crisprs	WYL,cas4,csa3,DEDDh,cas3	0	2	0	0

Cas Category Instructions

Results visualization

1. NZ_CP049935

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP049935_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049935_1

351792-351887

Orphan

Consensus_repeat	Method
GCAGGTCGGCGGCCTCGTCGGGCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049935_1

>merge|NZ_CP049935|1|351792-351887|CRISPRCasFinder
GCAGGTCGGCGGCCTCGTCGGGCTGCATCTTCGCGAGCAGCTCCTCCTGGCGCTCCGGCGGCAGCTCGGAGAGCAGGTCGGCGGCGTCGTCGGGCT

>NZ_CP049935|1|1|351792-351887|CRISPRCasFinder
GCAGGTCGGCGGCCTCGTCGGGCT	GCATCTTCGCGAGCAGCTCCTCCTGGCGCTCCGGCGGCAGCTCGGAGA
GCAGGTCGGCGGCGTCGTCGGGCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049935.1\|WP_166118348.1\|359837_361388_+\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|341286
NZ_CP049935.1\|WP_166118299.1\|341917_343534_+\|glycosyl-transferase	unknown	unknown	unknown
NZ_CP049935.1\|WP_166118339.1\|355794_356202_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166124168.1\|347753_349040_+\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NZ_CP049935.1\|WP_166118346.1\|359272_359704_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|132707
NZ_CP049935.1\|WP_166118321.1\|350786_351332_-\|DUF1003-domain-containing-protein	unknown	unknown	gnl\|CDD\|377629
NZ_CP049935.1\|WP_166118327.1\|352668_353241_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166118308.1\|346415_347051_+\|RNA-polymerase-sigma-factor-SigE	unknown	unknown	gnl\|CDD\|236606
NZ_CP049935.1\|WP_166124167.1\|343574_344849_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166118333.1\|353991_354762_+\|DUF222-domain-containing-protein	unknown	unknown	gnl\|CDD\|367155
NZ_CP049935.1\|WP_166118302.1\|344975_345149_+\|DUF3117-domain-containing-protein	unknown	unknown	gnl\|CDD\|371461
NZ_CP049935.1\|WP_166118330.1\|353461_354040_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166118315.1\|349474_349612_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166118336.1\|355236_355707_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166118344.1\|357579_359247_+\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|223715
NZ_CP049935.1\|WP_166118342.1\|356320_356623_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166118312.1\|347059_347596_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274904
NZ_CP049935.1\|WP_166118350.1\|361522_362509_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274680
NZ_CP049935.1\|WP_166118318.1\|349643_350777_-\|Mrp/NBP35-family-ATP-binding-protein	unknown	unknown	gnl\|CDD\|378455
NZ_CP049935.1\|WP_166118305.1\|345671_346307_-\|O-methyltransferase	unknown	unknown	gnl\|CDD\|226607

Protein	Function_ID	Function_description	E-value
NZ_CP049935.1\|WP_166124168.1\|347753_349040_+\|PDZ-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	3.09861e-91
NZ_CP049935.1\|WP_166118344.1\|357579_359247_+\|GAF-domain-containing-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	4.1809e-45
NZ_CP049935.1\|WP_166118308.1\|346415_347051_+\|RNA-polymerase-sigma-factor-SigE	gnl\|CDD\|236606	PRK09647, PRK09647, RNA polymerase sigma factor SigE; Reviewed.	3.37865e-108
NZ_CP049935.1\|WP_166118321.1\|350786_351332_-\|DUF1003-domain-containing-protein	gnl\|CDD\|377629	pfam06210, DUF1003, Protein of unknown function (DUF1003). This family consists of several hypothetical bacterial proteins of unknown function.	3.39899e-42
NZ_CP049935.1\|WP_166118333.1\|353991_354762_+\|DUF222-domain-containing-protein	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	5.80042e-11
NZ_CP049935.1\|WP_166118302.1\|344975_345149_+\|DUF3117-domain-containing-protein	gnl\|CDD\|371461	pfam11314, DUF3117, Protein of unknown function (DUF3117). This family of proteins with unknown function appears to be restricted to Actinobacteria.	3.92242e-21
NZ_CP049935.1\|WP_166118305.1\|345671_346307_-\|O-methyltransferase	gnl\|CDD\|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	9.07953e-54
NZ_CP049935.1\|WP_166118346.1\|359272_359704_-\|hypothetical-protein	gnl\|CDD\|132707	TIGR03668, Rv0121_F420, PPOX class probable F420-dependent enzyme, Rv0121 family. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. A variant of the Partial Phylogenetic Profiling algorithm, SIMBAL, shows that this protein likely binds F420 in a cleft similar to that in which the homologous enzyme pyridoxamine phosphate oxidase (PPOX) binds FMN. [Unknown function, Enzymes of unknown specificity].	1.07704e-16
NZ_CP049935.1\|WP_166118312.1\|347059_347596_+\|hypothetical-protein	gnl\|CDD\|274904	TIGR03988, antisig_RsrA, mycothiol system anti-sigma-R factor. Members of this family are the anti-sigma-R factor RsrA, which contains a CXXC motif as a thiol-disulphide redox switch. It interacts with sigma-R. It regulates and is regulated by the mycothiol system, which occurs in many actinomycetes. [Transcription, Transcription factors].	0.00116122
NZ_CP049935.1\|WP_166118350.1\|361522_362509_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274680	TIGR03619, F420_Rv2161c, probable F420-dependent oxidoreductase, Rv2161c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity].	2.7474e-37
NZ_CP049935.1\|WP_166118318.1\|349643_350777_-\|Mrp/NBP35-family-ATP-binding-protein	gnl\|CDD\|378455	pfam10609, ParA, NUBPL iron-transfer P-loop NTPase. This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.	2.46243e-125
NZ_CP049935.1\|WP_166118348.1\|359837_361388_+\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|341286	cd17631, FACL_FadD13-like, fatty acyl-CoA synthetase, including FadD13. This family contains fatty acyl-CoA synthetases, including Mycobacterium tuberculosis acid-induced operon MymA encoding the fatty acyl-CoA synthetase FadD13 which is essential for virulence and intracellular growth of the pathogen. The fatty acyl-CoA synthetase activates lipids before entering into the metabolic pathways and is also involved in transmembrane lipid transport. However, unlike soluble fatty acyl-CoA synthetases, but like the mammalian integral-membrane very-long-chain acyl-CoA synthetases, FadD13 accepts lipid substrates up to the maximum length of C26, and this is facilitated by an extensive hydrophobic tunnel from the active site to a positively charged patch. Also included is feruloyl-CoA synthetase (Fcs) in Rhodococcus strains where it is involved in biotechnological vanillin production from eugenol and ferulic acid via a non-beta-oxidative pathway.	2.65087e-166

>NZ_CP049935.1|WP_166118321.1|350786_351332_-|DUF1003-domain-containing-protein
MAERERRARIDQPRESTRRRFALPSAFSEESFGVLSEKFARFMGTPGFLIGMTIFIAAWIAFNTLTPWAFDPYAFLFLTLMLSLQASYAAPLILLAQNRQADRDRVALEQDRSRDERNLADTEFLTREVAALRIALRDMATRDFVRSELRDLLDEMEERGLAVTVAGADDGADDGERPDPT
>NZ_CP049935.1|WP_166118318.1|349643_350777_-|Mrp/NBP35-family-ATP-binding-protein
MPQVSTAALHAALETVIDPEIRRPVTELGMVGDLACDDDGRVAVTILLTVAACPLKDKLTGDTTAALSKVEGVTDVSVTLGVMSEEQRGELKTKLRGGTAEREVPFAQPGSLTRVYAVASGKGGVGKSSVTANLAASLAQEGLSVGVVDADIYGFSIPRMLGVEHKPTQVDDMIMPPVSHDVRVISIGMFVPGNQPVVWRGPMLHRALQQFLADVFWGDLDVLLLDLPPGTGDIAISVAQLVPGAEILVVTTPQQAAAEVAERAGSIALQTHQRLAGVIENMSWLELPDGTREEIFGSGGGREVAESLSRSIGSEVPLLGQIPLDTRLRVGADQGVPVVLGEPDSPAAVALRGIAKGLASRSRGLAGRSLGLSPVGR
>NZ_CP049935.1|WP_166118315.1|349474_349612_+|hypothetical-protein
MADDVVDEPLPYDEVGADLDAAYQPWLAPQEFDPGRPTPYDTDAT
>NZ_CP049935.1|WP_166124168.1|347753_349040_+|PDZ-domain-containing-protein
MGHRRHADDRASDVRPHGAVAPEPASAAATTQAYPPISGSWASVPPAPPNHPATPLSAPEPSRRRGPGWGALVGATVAAALLAGTGGGIVGGYLADRGSGSSGAPVAAPSPGAGATTRPQGSIANIAASALPSVVTLRVEGADGAATGSGWVYDDAGHVVTNNHVVAGADPGEDITVVLSDGRQVKGKVVGRDASYDLAVVKVSGASLAALPVGRSADVVVGDQVIAVGAPLGLDSTVTSGIVSALDRPVTPGQQDDQSYINAIQTDAAINPGNSGGPLLDMRGQVIGVNSAIARVPGSSISGQSGNIGVGFAIPSDQVATTVQQLIADGKAEHPVIGVYLDSAYQGEGVRIADGGPNSSPAVNPGGPADKAGLKAGDVIVAFEGKPVSDDGELVVKIRARKVGDSVKLTVRRDGKERDVTMVLQGSE
>NZ_CP049935.1|WP_166118312.1|347059_347596_+|hypothetical-protein
MGVQCLDDELSEYAAGRLGDERRDAWEHHLVACELCRHAVGQERRLREALAGAPSMPGDLRVTLLALGRGIAAEPRPAGGPGPLALLAPNDPPCHRSALRATVVAAAAGGVAAAAAWSLTVIGVPVAPRQGAVPGTSAPAVATSRPAAPLSATVVVPVRWTSGPSAPGSGGQRAESTP
>NZ_CP049935.1|WP_166118308.1|346415_347051_+|RNA-polymerase-sigma-factor-SigE
MSSLVRDEPMTTQQDAAPAWVPPSWEEVVEQHSARVYRLAYRLTGNVHDAEDLTQDVFVRVFRSLHTYQPGTFEGWLHRITTNVFLDKMRRKQRIRFDALSDESAARLPSRGPGPEQSFEDTHLDDDVQRALDALSPDFRAAVVLCDIEGLSYEEVAATLGIKLGTVRSRIHRGRSQLREALAHRAPTPRPEVTVAPRRGPIVRRPAAGAV
>NZ_CP049935.1|WP_166118305.1|345671_346307_-|O-methyltransferase
MSGLKPASWSYAEEFVPEPEVHEAARRRGVELGAASPVGTGAGAVLRLLAATVGARHVLEVGTGAGTSGLWLLAGMPDDGVLTTIDVSAEHQRLAKQAYTEAGYPHQRTRVITGAAAEVLPRMADGGYDMVHVDADKDTYPTYVEHAVRLLRPGGVLVVDNMLWHDRVADPAARDETTSTLRDLGKALRDHDDLVTALLPVSDGVLVAVRR
>NZ_CP049935.1|WP_166118302.1|344975_345149_+|DUF3117-domain-containing-protein
MAAMKPRTGDGPLEVTKEGRGIVLRMPLEGGGRLVVEMTPDEVRALGEAIDNCEGLN
>NZ_CP049935.1|WP_166124167.1|343574_344849_+|hypothetical-protein
MRGSVLRRLFSSEGRHELAGRALARPILTVLTVYALSRVVSLVALWVAATWFQNPAGVGHADPTVGDLIGLWDGVWYRRIVEDGYPVPLPVDADTGFYTYSAWAFYPLYPYLVKAVMVTGLSFEVAGAVLNLVLGAVAAVLVNALFRSTYHAARQPQRERLALVAACLWCLYPTTSVMLKPYTEALAVALVAGALLLLVRRQYLLVAAVALPLGLTRGVAPALGIAALIHLVVRWREERAAGLRPLAGQRAAVVTMLAALGVSGIAWPVIAGIATGVPTAFFDVQAAWGQKPADGPFVLWFAWAWDSKGVLGVCVLVALVATYVALVLGRHGRWMSVEVRAWALAYPLYLFAVVRPITSMWRFLLLDMPLAALLASVAMRTANGQQVVAHWKRRVAVVALVLVGGILWWTCSLLTYTPWGSFPP
>NZ_CP049935.1|WP_166118299.1|341917_343534_+|glycosyl-transferase
MQDQQAFEWYLGATAHNLSTFSNPLSSDLQNFPAGVNLMANAAVLGLGVPLTPLTLLAGPHVTFVLLELLGLALTATGWYWMTRRWLPVHPVAALLAGALAGFGPGMVSHANGHPNFVVQALVPVILDRLLRVLAGRRPVRDGVVLGLLTAWQVLIGEEVLLLTAIGVLVAAAVWLAHRRPPWRPVLTGLGLGALVTLVLVAVPLWWQFRGPQSYASIWHPPAGNDLAQLWGRATRTVGADPWASAAVSMNRTEENSFFGVPLLVAAAATVVLLWRSVLVRVLAAVVLVSCWLSLGEELTLHGTPLGIPGPWALLEHVPVVENVLPTRFTLVALPALALLLALGAEGLRRAVERYVGTPGPGLALATVTAVLVLLPVVPTPLVVDPRPVVPAFFTEGRWRDHVDEGGSVLAAPPPNVADARALEWQAAARWGFPVVAGYFVGPDGTEERGGQYGATPTGLTTWLAEVAQAGTEVPVGPSERAGFVEDLRAGRVDAVVLPEDRPAAAALRDSITSVFGAPRRLGGVYLWDVRELTDGQG
>NZ_CP049935.1|WP_166118327.1|352668_353241_-|hypothetical-protein
MPEEAAPDPAPDPSAGPDVTRLVHEAASKSGLLWIHVPGGGTHPVWHAWHDDGDSRGTGPAAYVVSGPGEQSLPWLPTQVEVILRSKDSGGRLLTMRATAEELATGSPEWEAAAEVLRPERLNATGDVVERWRQGCTIHVVTPHGRPVESPGHYEDGSGAAPVRPAGPATTRWRPWHWRGRARARRNTTP
>NZ_CP049935.1|WP_166118330.1|353461_354040_+|hypothetical-protein
MLSAASGAELCELLSVVDEVAALSAAARVSIAVEAVSRGEVAGAGVQAWLCENAPSLRQGGAAAVARIAVDVVASGSSSGRGVGPDEESPLGLVWAAVRDGSLGAGTACAVLREAARLEPVLRPEARPTVTEALVDLTVAHGTTMMRRLRPRLVAQYGQRGELDDLHRRLSPPPGCRCRASSPVASRSTSSG
>NZ_CP049935.1|WP_166118333.1|353991_354762_+|DUF222-domain-containing-protein
MPRIESGGLTEYQLWMTPEQAATLEAAIGPLSAPAPNAETGERDLRTAGQRRVEALTEVCRVASGPESSDTRGAATTLHVTMSLGDLQRVTGAGEVLDSVAEGTLVGPEALRRLACDAALVPHVLGSADEPLTVGRLVRLFTRAHRRHLRLRDRGCTFPGCTAPAAWARAHHVRHWVDGGRTDVTNAALLCQRHHTTVHRRRLWATVRERPDEHGRYVVWDLSDGSYDRGLAALMSHGPSPNRRPLDGDHQTTPAA
>NZ_CP049935.1|WP_166118336.1|355236_355707_+|hypothetical-protein
MWDWLLLGLLSPIVLLLGVGLPADWAQHNGKALKGSATVTSTETTRGGEVAVVEVRSVSGEVVASDQEVNGEAPHRVGATFPVDYLAPDGAGDTQVYVAGHDPFATNLLVFALVLVPWMTSLAFAGGRMAGMTRAWRRGRPGRPQRYSAGRGYIDD
>NZ_CP049935.1|WP_166118339.1|355794_356202_+|hypothetical-protein
MTPEGPRSLLEQVVGAVVGGAAEVEWVEPGDGWTAHVRLHGAGGRLSHVLTSPEVQEARFDVPPCSVVIVTTTDEDEVLEALAKLARAALEYSRGGGQVERARGVFGTRPVLVLRTEDGEWRIGKRSASIPYQRL
>NZ_CP049935.1|WP_166118342.1|356320_356623_+|hypothetical-protein
MVKKRRRATTFAELAGQPTWSETAAARQGEHAVRPGGVNVAGDFFDPSGRRLVFESADIGVDVAQQLVDAGALVVAESCGCGGGFGAARRSGWMTSSCAS
>NZ_CP049935.1|WP_166118344.1|357579_359247_+|GAF-domain-containing-protein
MSTAELPEVATALRPDDVREMLERQTELLELIAAAAPLRDVLTRILTSLEEFIPGARCSVLLLDRDRGTLHHGAAPSLPGAYVAAIDGLPIGDGAGSCGTAAALNTAVVAHDVRTDARWVAYRPVAEAAGLRSCWSTPIDGRDGLPVGTFAVYHPHPHRPTGREELLVDRFTHLASVAIEHADVLGELVESEERFRRSFDDNSLGMAILGLDRRVVTANTALAAVLGCEPPDLAGRPLAAVLSPTDGSLDARLDTLRPGDAQPVVFEATLHRPSGRELQVEVTVSLVHARDGAPAQYVVNVFDLTERRAAEQHRRARLEAETARRTAEQLLRERSALLAAVGHEARTPIQAIVGFVELLGTIELDQDRRREALARIDAAAGHVMDLLADVLDLSRLEAGALPLVPEPVRVREVVAEVLGLLAPVAERRDVGLAQSLDDDVVLADRRRLRQVLLNLVGNAIRHGVAGGGVEVRTRTADDGWVVLSVDDDGPGIPPELLPRVFTPFVRATPVAADDEGGIGLGLGLAHGLVEAMGGELTVGASSSAGTSMLVRLRRP
>NZ_CP049935.1|WP_166118346.1|359272_359704_-|hypothetical-protein
MKLDPDEARTRLAAEVHGVLVTLHPERGPDPQPVVYALSEDGHVGVPIDTVKPKTSSRLRREDNLEADPRGSLLVEHWETEDWSRLWWVRAQLEHLPDPPTTLTDELADRLARTVPQYADKPFHRILVCRVVAVTGWAASDDA
>NZ_CP049935.1|WP_166118348.1|359837_361388_+|long-chain-fatty-acid--CoA-ligase
MNLATWVERNGRRLRDRPALAVGEEVHGTWEVTAARVAALAGGLRDRFGLVPGDRVAIVMANRPEYLEAQFAAWHAGLVAVPVNARLHREEVAYVLEHSGTAAVVTDDEHADLVGPLVDRLDGLRAVVVAPGPEWDGLAASTPIALSDRGSDDAAWLFYTSGTTGRPKGATLTHGNLLMASLSYFADIGPVGDRDSVLHAAPLSHGSGLYGLPHVAKGAVSVFPSSGALDGAELAALVRRWPGLSFFAAPIMVKRLAADPALAGADLSGLKTVIYGGAPMYLADLEEALATFGPRLAQIYGQGETPMTITALSLADHAETDHPRWRERMQGVGFPRTDVEVRVADADDRPLPPGEAGEVLVRGPVVMAGYWDQEEESAETLRGGWLHTGDVGSLDDDGYLTLHDRSKDLIISGGMNIYPREVEEALMTHPGVQAVAVVGRPDPEWGESVVAFVVLGGDGSGPSAEDLDRTCLERIARFKRPKQYHLVEALPTNNYGKVLKRELRTWLEEGRVPDQR
>NZ_CP049935.1|WP_166118350.1|361522_362509_+|LLM-class-flavin-dependent-oxidoreductase
MKLALYLPNFRNHVTVKELEDLTDLAEELDFDSVWTLDRVIVPEASDRGELQYPFGMMEQFPPQMPVASNGKWFQGWPLLPWLAARTSKLRIGMSITDTPYRSPGVFAAECATIDHLSGGRLNVGIGAGWMPEEFDAASATHLFPRRHAHVRETIEICQGIWANETFEYHGEFADFAPSGFGHQPLQRPGPPIFFSGLKDPKRSARRVSKYGLAGWIGIQDTPRELAEWRAAIAQELEALGKSIDDLEMSSMIWFTITDTETDQTDNRKLTNILVGTEQQITDRLKAYQEAGLTMPLLWPPFADVPVSKTLDDLKRLKYDIMPKVEAS

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Crispr_ID: NZ_CP049935_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049935_2

1492453-1492550

Orphan

Consensus_repeat	Method
CGCACCACCAGAAGGCCCGGTATCACCTCGACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049935_2

>merge|NZ_CP049935|2|1492453-1492550|CRISPRCasFinder
CGCACCACCAGAAGGCCCGGTATCACCTCGACCCGCCGGTGCATGCCCCCGGTTCGAGGTGAAACCGCACCACCAGAAGGCCCGGTATCACCTCGACC

>NZ_CP049935|2|2|1492453-1492550|CRISPRCasFinder
CGCACCACCAGAAGGCCCGGTATCACCTCGACC	CGCCGGTGCATGCCCCCGGTTCGAGGTGAAAC
CGCACCACCAGAAGGCCCGGTATCACCTCGACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049935.1\|WP_166120447.1\|1484784_1485576_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|372616
NZ_CP049935.1\|WP_166120472.1\|1501682_1502585_-\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|237284
NZ_CP049935.1\|WP_166120441.1\|1484421_1484583_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166120474.1\|1502619_1503393_-\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|372611
NZ_CP049935.1\|WP_166120466.1\|1495557_1497018_-\|glutamate-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|237213
NZ_CP049935.1\|WP_166120436.1\|1476020_1477355_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240533
NZ_CP049935.1\|WP_166124278.1\|1504289_1505528_-\|tryptophan-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|235288
NZ_CP049935.1\|WP_166124277.1\|1477426_1478302_+\|NDP-sugar-synthase	unknown	unknown	gnl\|CDD\|224129
NZ_CP049935.1\|WP_166120444.1\|1484579_1484792_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166120450.1\|1485659_1488374_-\|DNA-polymerase-I	unknown	unknown	gnl\|CDD\|235591
NZ_CP049935.1\|WP_166120476.1\|1505545_1506346_-\|indole-3-glycerol-phosphate-synthase-TrpC	unknown	unknown	gnl\|CDD\|234710
NZ_CP049935.1\|WP_166120439.1\|1482624_1484421_+\|acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|224748
NZ_CP049935.1\|WP_166120479.1\|1506359_1506587_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166120462.1\|1492568_1493129_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP049935.1\|WP_166120456.1\|1488950_1490672_+\|DUF1800-domain-containing-protein	unknown	unknown	gnl\|CDD\|378055
NZ_CP049935.1\|WP_166120464.1\|1493287_1493881_-\|response-regulator	unknown	unknown	gnl\|CDD\|226230
NZ_CP049935.1\|WP_166120481.1\|1506654_1507260_-\|Trp-biosynthesis-associated-membrane-protein	unknown	unknown	gnl\|CDD\|378200
NZ_CP049935.1\|WP_166120469.1\|1497010_1501552_-\|glutamate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|236968
NZ_CP049935.1\|WP_166120459.1\|1490683_1492033_+\|DUF1501-domain-containing-protein	unknown	unknown	gnl\|CDD\|226587
NZ_CP049935.1\|WP_166120453.1\|1488372_1488804_+\|hotdog-fold-thioesterase	unknown	unknown	gnl\|CDD\|161843

Protein	Function_ID	Function_description	E-value
NZ_CP049935.1\|WP_166120447.1\|1484784_1485576_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|372616	pfam13489, Methyltransf_23, Methyltransferase domain. This family appears to be a methyltransferase domain.	3.14961e-20
NZ_CP049935.1\|WP_166120472.1\|1501682_1502585_-\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|237284	PRK13108, PRK13108, prolipoprotein diacylglyceryl transferase; Reviewed.	8.40886e-96
NZ_CP049935.1\|WP_166120474.1\|1502619_1503393_-\|thioredoxin-domain-containing-protein	gnl\|CDD\|372611	pfam13462, Thioredoxin_4, Thioredoxin.	2.80856e-23
NZ_CP049935.1\|WP_166120466.1\|1495557_1497018_-\|glutamate-synthase-subunit-beta	gnl\|CDD\|237213	PRK12810, gltD, glutamate synthase subunit beta; Reviewed.	0
NZ_CP049935.1\|WP_166120436.1\|1476020_1477355_+\|hypothetical-protein	gnl\|CDD\|240533	cd13128, MATE_Wzx_like, Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	5.93416e-10
NZ_CP049935.1\|WP_166124278.1\|1504289_1505528_-\|tryptophan-synthase-subunit-beta	gnl\|CDD\|235288	PRK04346, PRK04346, tryptophan synthase subunit beta; Validated.	0
NZ_CP049935.1\|WP_166124277.1\|1477426_1478302_+\|NDP-sugar-synthase	gnl\|CDD\|224129	COG1208, GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis].	9.92226e-59
NZ_CP049935.1\|WP_166120450.1\|1485659_1488374_-\|DNA-polymerase-I	gnl\|CDD\|235591	PRK05755, PRK05755, DNA polymerase I; Provisional.	0
NZ_CP049935.1\|WP_166120476.1\|1505545_1506346_-\|indole-3-glycerol-phosphate-synthase-TrpC	gnl\|CDD\|234710	PRK00278, trpC, indole-3-glycerol phosphate synthase TrpC.	1.55979e-124
NZ_CP049935.1\|WP_166120439.1\|1482624_1484421_+\|acyltransferase-family-protein	gnl\|CDD\|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	4.36258e-54
NZ_CP049935.1\|WP_166120462.1\|1492568_1493129_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	5.72781e-13
NZ_CP049935.1\|WP_166120456.1\|1488950_1490672_+\|DUF1800-domain-containing-protein	gnl\|CDD\|378055	pfam08811, DUF1800, Protein of unknown function (DUF1800). This is a family of large bacterial proteins of unknown function.	2.97907e-130
NZ_CP049935.1\|WP_166120464.1\|1493287_1493881_-\|response-regulator	gnl\|CDD\|226230	COG3707, AmiR, Response regulator with putative antiterminator output domain [Signal transduction mechanisms].	3.25414e-57
NZ_CP049935.1\|WP_166120481.1\|1506654_1507260_-\|Trp-biosynthesis-associated-membrane-protein	gnl\|CDD\|378200	pfam09534, Trp_oprn_chp, Tryptophan-associated transmembrane protein (Trp_oprn_chp). Members of this family are predicted transmembrane proteins with four membrane-spanning helices. Members are found in the Actinobacteria (Mycobacterium, Corynebacterium, Streptomyces), always associated with genes for tryptophan biosynthesis.	2.57814e-16
NZ_CP049935.1\|WP_166120469.1\|1497010_1501552_-\|glutamate-synthase-large-subunit	gnl\|CDD\|236968	PRK11750, gltB, glutamate synthase subunit alpha; Provisional.	0
NZ_CP049935.1\|WP_166120459.1\|1490683_1492033_+\|DUF1501-domain-containing-protein	gnl\|CDD\|226587	COG4102, COG4102, Uncharacterized protein conserved in bacteria [Function unknown].	5.00663e-51
NZ_CP049935.1\|WP_166120453.1\|1488372_1488804_+\|hotdog-fold-thioesterase	gnl\|CDD\|161843	TIGR00369, Putative_esterase, uncharacterized domain 1. Most proteins containing this domain consist almost entirely of a single copy of this domain. A protein from C. elegans consists of two tandem copies of the domain. The domain is also found as the N-terminal region of an apparent initiation factor eIF-2B alpha subunit of Aquifex aeolicus. The function of the domain is unknown.	9.70337e-33

>NZ_CP049935.1|WP_166120459.1|1490683_1492033_+|DUF1501-domain-containing-protein
MTLPTSPVPTAAAPTGPTSASEGHAACGCPEGIAVSGVSRRGVLAGATALGAAGATVALATPAEALTRLTFADAGYTGDTLVVLSFRGGIDGLSVVAPVGDAAYYTARPSIAVPQARGLQLDARFALHPALAPLLPLYTGGKLAVVHAVGQPNPTRSHFTDLDEMERAAPGSSLRTGWLDRMVGATTTPGAFASTAMGATSAPRSMLGPTPELAMRSVDAFSLNGAWDATEATRWTTALRALHVGAPDPIGAPARGTLDALSTVSDLRAAGYTPANGASYPSGALGDALRDTARLVKAGVGLRAVTIDSGNWDMHTDLGRSDSGWMFRQLTEVGRALAAFMTDLGTASDRVTLVTLSEFGRRVAENGSGGVDHGYGNFSFVLGGGVVGGSVYGTWPGLADSQLQAGDLKATTDYRSVLGEVLEKRCGVTASTVLPGLPSARLGLARART
>NZ_CP049935.1|WP_166120456.1|1488950_1490672_+|DUF1800-domain-containing-protein
MSPALPRRSTAAALLSGLVGTPSPDLTRRAKEAARRTMRATVLPAPDKPRSMPEAQPVPTAVPSSRAVDAAYRPRAAARLVATPITSVRRPVSRVGSGTTSEATALHLARRASFGATPALVAEIQARGAAGWVADQLDPLRLVPDATCDALVARLFPRLSLATWQVHDQYWPNSTGDLGTDVIESVVARALWSKRQLLEVMVEFWTNHLVVTAPWGETWDSVHRFHVDVVRKHALGRFSDMLVASAKHPAMLAQLDNESSTKRAPNENFGREVLELHTVGVDGGYLESDIRRSALALTGMSTDDESGEYYYRQIRHHVGSLSVMDWSHANTSAQGEAVGVAYLQYLARHPKTARRIATKLATRFVSDVPPASLVTSLAAVYTANDTAIAPVLTALFSSAEFAASVGQKVKRPLERIISTSRILEVAPGPDTRAWLSGLVWYSRVAGQAPLGWPAPNGYPDVAAAWAGANATLTAWNWTMSQGWTAVESPQTEVTYPALRSLLPATLPATHGAMVDALALRLLQGPIPAAKRDAVCAFLDKTAASPLRSTDAAVGWRLPYVVALLLDTPEFATR
>NZ_CP049935.1|WP_166120453.1|1488372_1488804_+|hotdog-fold-thioesterase
MTDSSDLMAGVQRMRAMNPDSLMERMGIEVVEATPERLVATMPVAGNTQPYGLLHGGASVVLAETLGSIGAALHAGEGKAVVGLDINATHHRAARSGLVTGTATPLSLGRTLACYEVVVTDEDGKRVCTSRITCLIRDAAPGA
>NZ_CP049935.1|WP_166120450.1|1485659_1488374_-|DNA-polymerase-I
MVVRLPRVKLLLLDGHSLAYRAFFALPVENFSTSTGQHTNAVYGFTSMLINVLRDEAPTHVCVAFDVSRQTFRLEEYSEYKAGRSKTPTEFSGQLPLLREVLDALRIKHIGLEGYEADDVIASLTRQATEAGAEVVICTGDRDAFQLVTEKVSLIYPVRGVSEVWRMDPAAVEEKYLVPPNRYSDLAALVGESSDNLPGVPGVGPKTAAKWLAQYGDLTGVVAHVDEIKGKAGENLRAHLDGVLRNRRLNKLVDDLELPLTVADLERASWDREEVHQVFDGLEFRVLRDRLFQTFDVESDEVEGGFELDGDVFTADDLTVRFGDGAVGRTVPHGVVVSGHYRAGEGDAGAVALAGDDGATAYLDLTALTAEQEQALAGWLADPDAPKVLHDVKPQLQALRARGLALNGVTSDTALAAYLVRPDQRSYDLEDLVVRHLGRELTAEGGATSDQGRQGTLTFDVETDDDTAERDAMVRARAVLELSAVLAEKVEETGGTELLADLELPLVDILAEMERTGIAVDEDALTDLEADFAAKMRQAQQDAYDAIGREDVNLGSPKQLQEVLFDQLGMPKTKRTKTGYTTDADALADLFTKTEHPFLEALLRHRDTSRLRVTVEGLIKSVAPDRRIHTTYLQTIAATGRLSSTDPNLQNVPIRTEEGRRIRDVFVVGEAFESLMSADYSQIEMRIMAHLSGDEGLIEAFRTGEDLHRFVGARVFGVEPEDVTLEMRSKVKAMSYGLAYGLSAFGLSKQLTIGTGEAQGLMDEYFARFGGVRDYLREVVVEARATGYTATMLGRRRYLPDLLSDNRQRREGAERMALNAPIQGSAADIIKLAMKGVDAALKAEGATSRMLLQVHDELVLEVAPGERADVEALVRREMGAAIDLGDVPLDVSVGVGRSWHDAAH
>NZ_CP049935.1|WP_166120447.1|1484784_1485576_-|class-I-SAM-dependent-methyltransferase
MTSFPEYYRENVTWVGSLDVRLAAIADLVVGRRPGRTLDLGCGQGVLLGALASRLPEGSHLVGMDVVPPPPGVRWRGVTADITGRLPFADDAFDVVVAGEVLEHVPHPDLLLAEIRRILQPGGRLVLSTPNIVGWANRVLVPLGIQPLFTETSSEVHLGRRWRVLGQGNQVQGHLKVFSHRALAEILARTGFTVLTTRGMPGEFPSPVDRVDRLCARFPSIASDLLVVAEPAVRVPDPAPARRKDTRPPSGGTRTARPTEDHG
>NZ_CP049935.1|WP_166120444.1|1484579_1484792_-|hypothetical-protein
MAEPEDGTRQVVTLSVGARVGATIALLLLVGAAYLLWSPIQLYPSDGFPIMCGSAANPRATASASRPAAR
>NZ_CP049935.1|WP_166120441.1|1484421_1484583_-|hypothetical-protein
MNRIRQWQSGSLLVAALVVAAGSVYAFGVGRRSERLIGSDASAPAEHAAASDD
>NZ_CP049935.1|WP_166120439.1|1482624_1484421_+|acyltransferase-family-protein
MFFVLSGFLITSLLVREWTRTGRIALRAFWMRRARRLLPAVVLVLLAVVSYDVATGAHQPLLRGDSLATLGYVSNWWFMVSDQSYFSQFLEPSPLRHTWSLAIEEQFYLVFPLLLVLLLGRLRWGLRRVRAVLLVGAVGSAALMAVLYQPLTDPSRAYYGSDTRVQALLVGALLALAPSLTAPAAPVFTRLNGRLVRLPGAALLGWVALAGLVAMFVGARELSPWMYRGGFTLAALLSAVLVASVSRAPRSALARLLSLRPVVAVGIVSYGLYLWHWPVFVVLGHDRTGLDGVPLLALRLAVTALLAVLSYRLVEEPVRTQRLQRRFTPTQWGRAVAAAMAAVVAVTVWGTPSALSVSPTPGEEVAGGRPAPVPDAQGRIVKAFLLGDSQAYAMRTHYGNTVDGLAVTGSTELGCQTLLADRSIDGQTYPSLPACAEWEPRWTEEVAREKPDLVVMMLGLGELYDRRVDGRVLTFGTPEYRAWLDREIDRRRQLVDGKARRFALTTALCLDISADAANPTTSIANDPRRLAWLNDTIRAYGREHPEVTVLDLFGTVCANGYTNEVDGVTLRDDGLHLNARGAALVWARIGPQVVEAAS
>NZ_CP049935.1|WP_166124277.1|1477426_1478302_+|NDP-sugar-synthase
MGSLSRDQPKHLLEVAGEPFVVHQLRWLAGHGVVDVVLATSHLADRFEPVLGDGRRWGVRLHYSVEPAPEGTGGGLRRAAHHLGSLPERLVVVNGDLLTRHDLTRQVALGLGRPDVEAVLHVRTVPDARPFGCVVADDAGRVSAFLEKSPHPPGHEVNAGTYVLDRSVVESIPEGVVSLEVDVLPRLVAGGRVLAHREDALWEDVGTPEALVRASRALVLASGADAHVDPTARVDPTALVAGGSAVGPGAVVGAGAHVLGSVVMSGAVVEAGAVVEDGAVAPGVTVSRARA
>NZ_CP049935.1|WP_166120436.1|1476020_1477355_+|hypothetical-protein
MGRDARAGSRSGAASGDALLGLGMVSASALGYVFVLLLSRSLGPADFGGFSSLNSIGLALSIPAGAFQVMYASRVARRGPEAFDLRLPLVVGGAVCLATVALSPVLAHLTRVDTVLAPVVVALGLPSLVLNGALMGGLLGLRRIGALSLAYVATGVSRVGAAAAASALGLGLVGSLTLIAVASLLVTGLLWWLCRADAHLPWAAPRSLREAVRTLYRSNSSTGVLMALTTVDVVLARYVLPRVESGEYALVSTLGRSPLWVTQFLALALIPTLATSGSRRSVLRAGGLVLGVCLAGTAVAAAAPDLWVGLLGGSAYRAAGDLLLPYLVLGTLLALAQVLIVAEMAQRRHVVATVAWLAVALEVTLVLTLARHSQLQVLGAAITATGLVVAVGVAQLVLGLRREPERPAATGAEEPTEPVVAPVTDPSTGATAPLAPSTRAPGGP
>NZ_CP049935.1|WP_166120462.1|1492568_1493129_-|GNAT-family-N-acetyltransferase
MSRRPVDVSVVGEDLHAVTALWLEARVDSGSSPEVCARTITDGRLASALRRPGVLAFVAHLDGEPAGYVITTDNPFGISPTPEVAIEQLWVTPGARKHGVAKSLIAAVLGSAERSGCELVVSNVPTTSREANRFFARLGFGSVVTRRVVATGTLRRKIAPETAETGLELTRRRRSLRQRAFPARSA
>NZ_CP049935.1|WP_166120464.1|1493287_1493881_-|response-regulator
MTQSAAPTKRVLVAEDEAIIRLDLSEMLREAGYDVVGQAGDGEQAVELTRSLRPDIVIMDVKMPVMDGLSAAEAIGAERLAPVVMLTAFSQTELVERARDAGVMAYVVKPFTASDVTPALDIALSRWSELKALEEEVADLGERLETRKAVDRAKGVLMAKLKISEADAFRWIQKTAMDRRMGMREVAEAVVAGMEKA
>NZ_CP049935.1|WP_166120466.1|1495557_1497018_-|glutamate-synthase-subunit-beta
MADPQGFLRTRERELPRRRPVPVRIRDWKEVYEDQPVPELQRQAGRCMDCGIPFCHSGCPLGNLIPEWNDLAWRGEWREAIDRLHATNNFPEFTGRLCPAPCESACVLGINQPPVTIKQVEVSVIDRAFENGTVLPQAPDRLSGKTVAVVGSGPSGLAAAQQLTRAGHTVAVYERADQPGGLLRYGIPEFKMEKAVLDRRIAQMKSEGTRFRTGVEVGRELTGADLRKRFDAVVVAIGATVPRDLPVPGRELDGVMQAMDFLPPANRVALGQTVEGQVTAQGKDVVVIGGGDTGADCIGTAHRQGARSVTSLEIMPQPGLERAGAHPWPTYPMLFRVASAHEEGGDRVYATTTSEVVGDDEGRVRALRLHEVRMGENGFEKVEGSEREIPAQLVLLAMGFLGPQAEGLLEQLGVEQDPRTNVARDGHFMSSVPGVFVAGDAGRGQSLIVWAIAEGRSVAHEVDAWLMRKPSRLPRPVNPTDRPLTA
>NZ_CP049935.1|WP_166120469.1|1497010_1501552_-|glutamate-synthase-large-subunit
MTVARFSAQPDDVGLYRRAHEHDACGVAMVATMRGSAGHDIVVHALDALRNLDHRGATGADPLVGDGAGILTQVPDRFFRSVLDVELPPAGAYAAGMAYLPTDEAERAEAERRITEIAEEEGLTVLAWRDVPVVPDLVGEAARATMPCFRQLFVASRDGLTDIALDRVAFALRKRAEREVVVYFPSLSARTVVYKGMLTTGQLEPFFPDLSDERFATELALVHSRFSTNTFPSWPLAHPYRLIAHNGEINTVKGNRNWMHARESQLASDVLTGDLSRLSPVCTPEASDSASFDEVLELIHLGGRSLPHAVLMMIPEAWENHDSMDPARRAFYEFHSTFMEPWDGPAAVCFSDGTLVGAVLDRNGLRPGRYWVTDDGLVVLASESGVLDLEPENVVRRGRLQPGRMFLVDTAAGRIVSDEEVKSGLAAEHPYEEWLHAGLIELGDLPEREHIIHTAASVARRQRTFGYTEEELKILLAPMARTGAEALGSMGTDTPIAVLSERPRLVFDYFTQLFAQVTNPPLDAIREELVTSLASTIGPEGNLLDANAAHARQVVLPFPVLDNDELAKIVHINADGDLPGFETVVVRGTYDVTGGEDALRSRLHEIFAEVSAAIAGGVRFVVLSDRDSDRDTAPIPSLLLTSAVHHHLIREKTRTQVGLIVEAGDVREVHHVALLIGYGAAAINPYLAMESVEDMVRRGDITDVTEEKAVANLIKALGKGVLKVMSKMGISTVASYRGAQVFEAIGLAQALVDEFFTGTVSQLGGVGLRVLAAETAARHEAAYPPDGIRQAHRKLVVGGEYQWRREGEPHLFDPETVFRLQHATRQRRYDVFKQYTSRIDEQSGRLMTLRGLFSLGGAEPREPVPLEEVEPVESIVKRFSTGAMSYGSISKEAHETLAVAMNRLGARSNTGEGGEDEDRLLDPTRRSAIKQVASGRFGVTSMYLTHADDIQIKMAQGAKPGEGGQLPGPKVYPWVAKTRHSTPGVGLISPPPHHDIYSIEDLAQLIHDLKNANPSARVHVKLVSEIGVGTVAAGVSKAHADVVLISGHDGGTGASPLTSLKHAGGPWELGLAETQQTLVLNGLRDRIVVQVDGQIKTGRDVVIAALLGAEEFGFATAPLVVSGCILMRVCHLDTCPVGIATQNPELRERFSGQPEFVETFFEYIAEEVREHLAALGFRTVEEAIGQIQHVDVSRAVEHWKASGLDLSPILTRVQSPDGSGIRHRVGQDHGLEKALDHQLIAAARDAIDNGEPVRARFGIRNVNRTVGTMLGHEVTRAHPEGLADGTIDLTFTGSAGQSFGAFLPAGITLRLEGDANDYVGKGLSGGRVVVRPAPGSALVAEDNVIAGNVIGYGATSGELFLRGRVGERFCVRNSGATAVVEGVGDHGLEYMTGGTALILGPTGRNVAAGMSGGVAYVLDLDPARVNPELVDLRPLRAEDELVVHDLLERHQRWTDSSVAARLLADWGTARSAFTLVLPRMYQRVLDVRAKAEAEGLDPDGTQVWERIMEASRG
>NZ_CP049935.1|WP_166120472.1|1501682_1502585_-|prolipoprotein-diacylglyceryl-transferase
MLTYLPSPTVGALHLGPLTVRAYALCILAGIVLAVWLTGRRLASRGIDGGVVLDVSAWAVIFGIVGGRLYHVVTTPGPYFGEGGNLLDAVKIWNGGLGIWGAVALGALGAWIGCKRSGVPFLQFADAAAPGVAFAQALGRWGNWFNNELHGAPTTLPWGLRVYEWDQPAGRAVTDSAGDPVVAGVFHPTFLYEFLFLVVLGTLLLVVDRRRRLAPGQLLGLYVAGYPIGRIVVEKMRTDEAELILGQRLNVWTSILVFLLGVWIVWFTGRRAAGSPPAEEAPEGAPDDTVESHPESQDVG
>NZ_CP049935.1|WP_166120474.1|1502619_1503393_-|thioredoxin-domain-containing-protein
MAKKTSTKASGNARQAKIQAAQKTSGGGANKIVVATVVAVVAIIAVVGGVVWSQAKKQASVGTSTAVPAGTSMGKGFRAYADVKPVAGAPTVDLYEDFQCPVCGQFEGVLGETIRELGQTGKIQLTYHVLNFLDGKSGAKNSTPAANGAFCAARTDKFQQFHDAVYTNQKPEGEDVDQATLDGWAKAAGISGDALTAWNTCVADGTFTRYVDSVNSAAFDDAKINGTPTIMINGEMKDLNAVATPDQLKKAVEDATK
>NZ_CP049935.1|WP_166124278.1|1504289_1505528_-|tryptophan-synthase-subunit-beta
MAEEPTTVGLTVDELPRPGRFGDFGGRYVPEALVPALDQLDEARQKAAVDPEFQDELARLHATYTGRPSIITEVPRFAAHCGGARVVLKREDLNHTGSHKINNVLAQALLAKRMGKTRVIAETGAGQHGVATATAAALMGLDCVVYMGRVDTERQALNVARMRILGAEVVAVEHGSATLKDAINEALRDWVTNVRTTHYIIGTVTGPHPFPEMVRDFHAIIGEEARAQVLELAGRLPDAVIACVGGGSNAMGIFHRFVPDAGVRLIGVEAGGEGVESGRHAARFAADATPGVLHGAMSYLMQDDDGQTVESHSISAGLDYPSVGPEHAFLRDSGRAEYRYATDEKVMEAFTLLCRTEGIIPALESAHALVGAMEVGRELGPDALLLVNLSGRGDKDMHTAAAYFGLVEEGTQ
>NZ_CP049935.1|WP_166120476.1|1505545_1506346_-|indole-3-glycerol-phosphate-synthase-TrpC
MTTVLDGIVAGVREDLAAREAALPLPALRDAVASAPPALDAEAVLRRPGLSLIAEVKRASPSKGALSDIPDPAALASAYAAGGASAISVLTEARRFGGSLDDLDAVRAAVSVPVLRKDFVVTEYQVWEARAHGADIVLLIVAALDDATLAGLLALVGELGMTALVEVHDEAETQRALDAGATVIGVNARNLKTLEVHDDTFSRLRPLLPPGVVTVAESGITGPADAGAYAAQGADVVLVGEALVRTGDPAGAAAAIVAAGAAEVLS
>NZ_CP049935.1|WP_166120479.1|1506359_1506587_-|hypothetical-protein
MDEHEDHGHSVAAWTAVTIIIVASVIMSVAVVFPNLWLFVGGAVLAVVGAVAGKVLSMAGYGAAGRDHVEHASIR
>NZ_CP049935.1|WP_166120481.1|1506654_1507260_-|Trp-biosynthesis-associated-membrane-protein
MRRLTGKGPVALLALLGAGVVLVAGFRPWVSGSVADAVLGGSRVTATGSEVAPGLSAVALAVAAAGIAVVAAGRVGRLVALVLWVACLATAGVLVGRVLADPSGVLGPVAASRVGRTGTVEAVASSTVWPWVAVLGLVLATAALVGALVGRRRWAAPARRYERAGTSDGHVAGSRGERVGTAWDDLSAGRDPTDVGDERRT

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Crispr_ID: NZ_CP049935_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049935_3

1734693-1734777

Orphan

Consensus_repeat	Method
ACCCGGCTCGCGAGCCGCCTCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049935_3

>merge|NZ_CP049935|3|1734693-1734777|CRISPRCasFinder
ACCCGGCTCGCGAGCCGCCTCGGGTCGTCCCGAGCCCTCCCGGCTCGGCTCGCGACGGCCGCACCCGGCTCGCGAGCCGCGTCGG

>NZ_CP049935|3|3|1734693-1734777|CRISPRCasFinder
ACCCGGCTCGCGAGCCGCCTCGG	GTCGTCCCGAGCCCTCCCGGCTCGGCTCGCGACGGCCGC
ACCCGGCTCGCGAGCCGCGTCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049935.1\|WP_166124306.1\|1739573_1739921_+\|DUF4870-domain-containing-protein	unknown	unknown	gnl\|CDD\|378240
NZ_CP049935.1\|WP_166120994.1\|1742052_1742523_-\|DUF4442-domain-containing-protein	unknown	unknown	gnl\|CDD\|373120
NZ_CP049935.1\|WP_166120976.1\|1733820_1734168_-\|histidine-triad-nucleotide-binding-protein	unknown	unknown	gnl\|CDD\|238607
NZ_CP049935.1\|WP_166120982.1\|1736715_1737747_-\|heat-inducible-transcriptional-repressor-HrcA	unknown	unknown	gnl\|CDD\|234621
NZ_CP049935.1\|WP_166121000.1\|1746365_1746884_+\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|367091
NZ_CP049935.1\|WP_166124307.1\|1742587_1743145_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240041
NZ_CP049935.1\|WP_166120959.1\|1721821_1725694_-\|DUF3376-domain-containing-protein	unknown	unknown	gnl\|CDD\|274676
NZ_CP049935.1\|WP_166120962.1\|1726505_1727201_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NZ_CP049935.1\|WP_166120964.1\|1727268_1727937_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NZ_CP049935.1\|WP_166120968.1\|1729388_1729949_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NZ_CP049935.1\|WP_166120973.1\|1732210_1732678_-\|rRNA-maturation-RNase-YbeY	unknown	unknown	gnl\|CDD\|234575
NZ_CP049935.1\|WP_166120985.1\|1737914_1738799_+\|DUF3097-domain-containing-protein	unknown	unknown	gnl\|CDD\|378628
NZ_CP049935.1\|WP_166120988.1\|1738795_1739104_-\|TfoX/Sxy-family-protein	unknown	unknown	gnl\|CDD\|377438
NZ_CP049935.1\|WP_166120967.1\|1728607_1729279_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NZ_CP049935.1\|WP_166120960.1\|1725699_1726212_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274676
NZ_CP049935.1\|WP_166120980.1\|1734789_1735533_-\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	unknown	unknown	gnl\|CDD\|236959
NZ_CP049935.1\|WP_166120997.1\|1744340_1746176_-\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NZ_CP049935.1\|WP_166120970.1\|1729967_1730909_-\|GTPase-Era	unknown	unknown	gnl\|CDD\|234624
NZ_CP049935.1\|WP_166120965.1\|1727936_1728608_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NZ_CP049935.1\|WP_166120991.1\|1741254_1742037_+\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|379135

Protein	Function_ID	Function_description	E-value
NZ_CP049935.1\|WP_166124306.1\|1739573_1739921_+\|DUF4870-domain-containing-protein	gnl\|CDD\|378240	pfam09685, DUF4870, Domain of unknown function (DUF4870).	2.35047e-27
NZ_CP049935.1\|WP_166120994.1\|1742052_1742523_-\|DUF4442-domain-containing-protein	gnl\|CDD\|373120	pfam14539, DUF4442, Domain of unknown function (DUF4442). This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 139 and 165 amino acids in length. There is a conserved PYF sequence motif. There is a single completely conserved residue N that may be functionally important.	4.55179e-67
NZ_CP049935.1\|WP_166120976.1\|1733820_1734168_-\|histidine-triad-nucleotide-binding-protein	gnl\|CDD\|238607	cd01276, PKCI_related, Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a hydrophobic residue) that is a signature for this family. No enzymatic activity has been reported however, for PKCI and its related members.	9.30468e-44
NZ_CP049935.1\|WP_166120982.1\|1736715_1737747_-\|heat-inducible-transcriptional-repressor-HrcA	gnl\|CDD\|234621	PRK00082, hrcA, heat-inducible transcription repressor; Provisional.	1.93428e-138
NZ_CP049935.1\|WP_166121000.1\|1746365_1746884_+\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	6.54535e-12
NZ_CP049935.1\|WP_166124307.1\|1742587_1743145_+\|NUDIX-domain-containing-protein	gnl\|CDD\|240041	cd04685, Nudix_Hydrolase_26, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	4.85504e-32
NZ_CP049935.1\|WP_166120959.1\|1721821_1725694_-\|DUF3376-domain-containing-protein	gnl\|CDD\|274676	TIGR03607, TIGR03607, patatin-related protein. This bacterial protein family contains an N-terminal patatin domain, where patatins are plant storage proteins capable of phospholipase activity (see pfam01734). Regions of strong sequence conservation are separated by regions of significant sequence and length variability. Members of the family are distributed sporadically among bacteria. The function is unknown. [Unknown function, General].	1.98653e-35
NZ_CP049935.1\|WP_166120962.1\|1726505_1727201_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	2.69181e-13
NZ_CP049935.1\|WP_166120964.1\|1727268_1727937_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	1.1094e-11
NZ_CP049935.1\|WP_166120968.1\|1729388_1729949_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	4.19223e-10
NZ_CP049935.1\|WP_166120973.1\|1732210_1732678_-\|rRNA-maturation-RNase-YbeY	gnl\|CDD\|234575	PRK00016, PRK00016, metal-binding heat shock protein; Provisional.	5.74592e-66
NZ_CP049935.1\|WP_166120985.1\|1737914_1738799_+\|DUF3097-domain-containing-protein	gnl\|CDD\|378628	pfam11296, DUF3097, Protein of unknown function (DUF3097). This family of proteins with unknown function appears to be restricted to Actinobacteria.	3.67335e-146
NZ_CP049935.1\|WP_166120988.1\|1738795_1739104_-\|TfoX/Sxy-family-protein	gnl\|CDD\|377438	pfam04993, TfoX_N, TfoX N-terminal domain. TfoX may play a key role in the development of genetic competence by regulating the expression of late competence-specific genes. This family corresponds to the N-terminal presumed domain of TfoX. The domain is found as an isolated domain in some proteins suggesting this is an autonomous domain.	7.21078e-12
NZ_CP049935.1\|WP_166120967.1\|1728607_1729279_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	9.47321e-12
NZ_CP049935.1\|WP_166120960.1\|1725699_1726212_-\|hypothetical-protein	gnl\|CDD\|274676	TIGR03607, TIGR03607, patatin-related protein. This bacterial protein family contains an N-terminal patatin domain, where patatins are plant storage proteins capable of phospholipase activity (see pfam01734). Regions of strong sequence conservation are separated by regions of significant sequence and length variability. Members of the family are distributed sporadically among bacteria. The function is unknown. [Unknown function, General].	1.63829e-29
NZ_CP049935.1\|WP_166120980.1\|1734789_1735533_-\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	gnl\|CDD\|236959	PRK11713, PRK11713, 16S ribosomal RNA methyltransferase RsmE; Provisional.	1.98479e-65
NZ_CP049935.1\|WP_166120997.1\|1744340_1746176_-\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NZ_CP049935.1\|WP_166120970.1\|1729967_1730909_-\|GTPase-Era	gnl\|CDD\|234624	PRK00089, era, GTPase Era; Reviewed.	2.15609e-158
NZ_CP049935.1\|WP_166120965.1\|1727936_1728608_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	4.36866e-09
NZ_CP049935.1\|WP_166120991.1\|1741254_1742037_+\|tyrosine-protein-phosphatase	gnl\|CDD\|379135	pfam13350, Y_phosphatase3, Tyrosine phosphatase family. This family is closely related to the pfam00102 and pfam00782 families.	6.05891e-62

>NZ_CP049935.1|WP_166120976.1|1733820_1734168_-|histidine-triad-nucleotide-binding-protein
MSETQDCLFCRIVAGEVPADVVAETEHSLAFRDISPQAPTHALVIPRRHVPDVASLAAAAPDELADVVTLAAAVAEGDGLPGYRLAANTGAAAQQTVFHAHVHVIGGRELTWPPG
>NZ_CP049935.1|WP_166120973.1|1732210_1732678_-|rRNA-maturation-RNase-YbeY
MSIDVLNETEVRVDELELVACARYVLAQMKVHPQADLCLRLVDEAAMETLHVQWMDLPGPTDVMSFPMDELRPGRDGVPPEEGVLGDIVLCPTVAAKQARDAGHATEEELLLLTTHGILHLLGFDHAEADEEKEMFELQRQLLLTFLATRGRPGA
>NZ_CP049935.1|WP_166120970.1|1729967_1730909_-|GTPase-Era
MSETTDTGAAEGYVAGFACFVGRPNAGKSTLTNALVGQKVAITSSKPQTTRHTIRGIVTTERSQLVLVDTPGLHRPRTLLGQRLNDLVRETLLEVDVIGFCLPADQRVGPGDQFIANELAELPRGKRTPVVAVATKSDSVDRGRLAEHLIAIDQLGDWDAIVPCSATRGDQVDDVASVLSGYLPPSPGPLYPDGQLTDEPEAVMVAELVREAALEGVRDELPHSLAVVVDEMVPREGRPADDPMLDVRVHVFVERDSQKAIVIGRGGSRLREVGTNARRGIEALLGTRVHLDLHVKVAKDWQRDPKQLQRLGF
>NZ_CP049935.1|WP_166120968.1|1729388_1729949_+|helix-turn-helix-transcriptional-regulator
MWFEDRTRQSIWNMQRSFQVSLNRQVFELDERARDKGVEERSVLPRHAALGSPLATTIEPSLRLGPVPIPMLVSDVSYAILQGPLGPHGLNTPYGTEDPDLVGLAAAAFLETWEAAIPWQEAGLRPPLEARRFRIAVMLMDGHTDRGIAAELGTSLRTVSSEVRAIVDWLGARNRGHAVAMLVGAA
>NZ_CP049935.1|WP_166120967.1|1728607_1729279_+|helix-turn-helix-transcriptional-regulator
MPGSAAAALLEATELAFIADDGTVTVYPPRPELVAMLTLFEAETGRVVRSMQRQLTMSASRAALALDDRSRQRGVREEVVIDRRAVLSSPLATTVDPGLRVGSVPTPVMLSDERLALLAVPPGRAPEGGCCWTVDPQLVRLALAAFLETWDAALPWQEAGLRPPLPERRFRVAVLLMDGHTDREIADELGISTRTVSDEVRAVVDSLGARSRSHAVAMLVGAA
>NZ_CP049935.1|WP_166120965.1|1727936_1728608_+|helix-turn-helix-transcriptional-regulator
MPGPAVERFLATVHPLLRDADPALSRLGERHELVAVFGDLEARTRRSLWNMQVSVGAAFAHRTRPLNASSRARGIEERMIHDRTQAARLPLVTTYDPHLRVGSVSTQLMVLDERYAVLPGAPGTDDTWSAFGTADPDLVALARAAFLETWEAAVPWSEAGLRPPLPQRRFDVAMLLVDGRSDREIAGELGISARTVSLEVRAVIDWLGARSRSHAVAMLVGAA
>NZ_CP049935.1|WP_166120964.1|1727268_1727937_+|helix-turn-helix-transcriptional-regulator
MPELDTFVALVARLTRAGDPRLVHVGDTASGRAHLEVVAARTTTSVWNMQREYGVSMERAARTLNAGTRAAGLEERDVVSLRGAQHHPLTTTFCPTLRIHSVPLLLLVADRREVVVSGPEAMPDGSLPAWASDDPGVVAHAVRAFEEIWSAARPWSEVGLRPPLPPRRREVALGLLSGRSDREIAQELGTSERTVSAEVRAVVDWLGARNRTHAVAMLVGAG
>NZ_CP049935.1|WP_166120962.1|1726505_1727201_+|helix-turn-helix-transcriptional-regulator
MGQVGNGGGEDAAAFFRWVHGLATAGDRRMAPLGSLAPAFDEGVAQLAGAVRRSVWHMTFRPTWSEVRMARPIAEVSRRRGIDARYVADRLASARLPLLSSHHHPYFRNHPVVAPLLVVDTRTVFVGAPPGHELAGEVWTSTAPQVVDGAIRVFDAVWRAATVPHPEDAPPFTRRMVDVAFLLTDGSSDREIARSMGVSERTVSAEVAEITRRLGARNRAHAIALIGDAGP
>NZ_CP049935.1|WP_166120960.1|1725699_1726212_-|hypothetical-protein
MDPQPVPAGPAAPSGLRGADLALVPPEELRLAVVLNGGVSLAVWMGGSVLEVDRLAHADRPGNGTYATMLALAGCRARVDVITGTSAGGINGAALALAQVNEDADLSILREVWAEQGRFETLLRSPVKGSPASLFKGDEHFLPELHTALARLARTTDPRRLASPEEAPST
>NZ_CP049935.1|WP_166120959.1|1721821_1725694_-|DUF3376-domain-containing-protein
MTTVLRGTETVTIDALGQRLPQSVHGGSFGWTRLPARSAGTTAPEDDPFSSGRIVRTAAQMALAARASSSFPVAFEPTFVPVGAPPAHDDDPRAALWPDMADVASWAGAEGEDRSRFVVDGGVLANTPTKAAMRGIMAMPAHGAVRRVLLLVYPHAPSPQAAPPDAATSAPALTRTLAGVAGALSAQGSRTFVDEVTAFNEAAISRRGTRVEILGQLVTDRGTKRRTLPVLAEDLAARLFEHYRSARRTRAARSVAAKVVEGLPSRAWCDEEEAWDLERVRRAAERAHVEGLTGPAGETGWLPYLPTRASARPDEGTSDGWAWGDGGALGVVEAANDVLRTLSWVVPGTEATACAAIGEARLAATTAVDALAAVRRAIDDRWEDPLLRTLRPDDQYWRMRLAAYALRMTGTSRDAADTAAERVVATDRERVLEATGDAVAADRRAEALRAAVERALGVGALPGGPSTRRLSACTDDGAGPGACGREVAAVVRGVVDALRTHALPVLVTYCREHPLDGSGGGGVLGGLEELHRWHDFLAPGGSVPRSTDDLLVRLLHLEVLSTVLGDGSPTGLSIPVELVQLSAQTQNPSTEFSRTADDKLGGWSLNRFGGFLKRSWRVNDWTWGRVDAATVLARTVLSPARLRRAAHLSGYLATGSPDVLARHTLDDLLGTLFAGTGLEDDPRVRGLRRRAFRELHEAFRTEVAAESLPATMPALAALFAWALHLELVGPELAALVAAVREDEVDGASPRSRGAVFLATEQHLVAGLGGVRDPRDVAPRDRVRALEAFDRAGVGREPLTTEMASDLLIRSAATAGAVTASVLDAPSSGLERVRPLTRVLRGAMLAVHWLVVGLTSRAAVPRSLALLGLSFGGVLLVASLFGVLPQAWSAPAALLGIGALLAAFGYGALRTGTVLHGVVLLSPLVPLVTFALTPADPVPLPDGAGAAQAAVQAAASSVSATRGGVTLAAVLGVVLGLYLLGSLPQSFGSPWLLLGRLADDYRVPAPDRPPRTALGRLGSGARRRLVGVARWLPSVLGPALVVALPVALAAWVASTGAEGIARFVLAHRGWLAVAAGLAVLAGMAMTFRFGDLLRPLARVVLDDGECTWRFGALVSPVQVTASWSVLYGLGYLVLGLGVAWRWLEPTSPPWLVALCVSALGLGLALAVGMPMVSPLLALRTLERAEHRRDPEARRFVVHDPVALPGHPEAVLVRWTAQRSYAVDLVERGVGYRWLVGDAPGPDGRAPSLRPRGVELLRRLDEDRDLRVLTWRRRLRRVAWRPLTWRARRRKR
>NZ_CP049935.1|WP_166120980.1|1734789_1735533_-|16S-rRNA-(uracil(1498)-N(3))-methyltransferase
MTLPVYLLEPGALSSSVVGGVVRLDGPEGRHAVAVRRTRAGERVVLADGGGRSVEGEVVAAERDVLDVRVEVVRDEPEPSPRFVLVQALAKGDRDDQAVEAATECGVDEVVPWQAARSIVQWRGERGEKARRKWDAVLVAATKQSRRTRRPVLGATASTTDVVARAREAALVLVLHEDAAEPLAGVVLPDAGDVLVVVGPEGGITPEEVAALEAVGARTVRLGPTVLRASSAGPAALAVLSAVSRWR
>NZ_CP049935.1|WP_166120982.1|1736715_1737747_-|heat-inducible-transcriptional-repressor-HrcA
MSEDRRLRVLRAIVQDYVQTSEPVGSKALLDRHQLGVSAATVRNDMAALEEEGLIAAPHTSAGRIPTDAGYRVFVDRLSQVKPMSPAEQRAIGHLLEGAVDLDDVVDRTVRLLASLTRQVAVVQYPSLSRSSVRHVELVPIGGPRLLVVLITTTGRVEQRVVDVGTDLLTDDGEATLATLRTELNAATGGRVLADASTELASVPDRLDPTVREVCRAVVTALEDSLVEEREERVVLAGTANLARAGADFTQSIGPVLEALEEHVVLLRLLGTVAEQGGTLAVRIGHENPYAGLQSTSMVTTGYGAGSDLVAGLGVVGPTRMDYPSTMAAVRAVATYVSRILAD
>NZ_CP049935.1|WP_166120985.1|1737914_1738799_+|DUF3097-domain-containing-protein
MTDRYGADVLSGDWRKPPRGRSVELPAETGTVVEEVETGWVGAVVRVEKAGGVHVVHLEDRRGRVRGFPLGPGFLVDGSPVRLVAPKVAAQARLDAARAGSERTASGSRAVQGQRARVASGSRIFVEGKHDAELVEKVWGDDLRVEGVVVERLDGVDDLAGAIRDFAPGPGRRMGVLVDHLVPGTKESRVVDEARRLRPWAQHVLVVGHPYVDVWQSVKPGRLGMNAWPVIPRGTSWKHGIAAHLGWPHDTQADMARAWRRILASVGSWTDLEPELLGRVEELIDFVTAPSAQA
>NZ_CP049935.1|WP_166120988.1|1738795_1739104_-|TfoX/Sxy-family-protein
MELLERVRAALPPAEEKRMFGGVGFMVDGALACSVGPRGLLVRTGTADFDDLVGRAGVEPMVMGGRSSRGWVDVHADVLADDAALRGWLDVGVAAARAAGAP
>NZ_CP049935.1|WP_166124306.1|1739573_1739921_+|DUF4870-domain-containing-protein
MSPQDEKTWGMAAHGIALAATVFSGGFLSFVAALVMYLIVKDRGPFVRAHTANALNVQILVGIVFVVSIPLMFVLIGFFTFAAAWVFAVVVHIVGIIKANNGEWWDPPMTPKFVR
>NZ_CP049935.1|WP_166120991.1|1741254_1742037_+|tyrosine-protein-phosphatase
MPDRWIDLDGLVNMRDVGGLPTRDGGTTVSRRLIRSDNLQDLSELDVDRLVHELGVTDVVDLRTETELHLDGPGPLRRTTDLAHHHHSLLPQRAPESADEIAARALALPQDERPVRDAAFWSEHYLGYLAKRPDSVSAALRVVADAAGAAVVHCAAGKDRTGTVVAMALDVAGVPREEIVADYALSAERIEAIIRRVAGSDAHGPFLREQSVADQTPRAETMEAILDAVADGWGDAAGWLRAQGWGDDDVQRLRARLTQP
>NZ_CP049935.1|WP_166120994.1|1742052_1742523_-|DUF4442-domain-containing-protein
MTDTVALYRRLSARPGGRRAFSLLFSLKAPYFRTVRPQVREVRPHHAELVVGKRWGVQNHIGTVHAIAVCNGLEAAMGLLAEATTPSTHRWIPKGMTVAYLAKSTTDLLCVAETDPADWEVGAAGDVPVRVRAVRTDGTVVVEGTITIYVSEKPSR
>NZ_CP049935.1|WP_166124307.1|1742587_1743145_+|NUDIX-domain-containing-protein
MPGQPGFVLPDPADRPHFERRAVRVLVLDEDERVLLFLDSDLGLDPVAHWWDTPGGGVDPGESDREAVVRELAEETGQVVEDADVVGPLFERLVVHGYSDKVVEQTEVWFAVRRPAFEVDASGYTEEERLCIAETRWWSLADLASAPDEVWPADLADLVALVDRPDAWRAGAVAGEPVEESSLPA
>NZ_CP049935.1|WP_166120997.1|1744340_1746176_-|elongation-factor-4
MLQPHATPPEAIRNFCIIAHIDHGKSTLADRMLQITGVVDDRAMRAQYLDRMDIERERGITIKSQAVRMPWEVDGASHVLNMIDTPGHVDFTYEVSRSLAACEGAVLLVDAAQGIEAQTLANLYLAMENDLTIIPVLNKIDLPAAQPEKYAEELAGLIGCEPEDCFQVSGKTGVGVEPLLDSIVAQIPSPTGDADAPARAMIFDSVYDTYRGVVTYVRVIDGNLNPRERIVMMSTKAHHELLEIGVISPEPVPGKGLGVGEVGYLITGVKDVRQSKVGDTVTNAAKPATDALGGYRDPKPMVFSGLFPLDGSDYPDLREALDKLKLNDAALVYEPETSVALGFGFRCGFLGLLHLEIVRERLEREFDLELISTQPNVVYDVTMDDGSRVTVTNPSEFPGGKIAEVREPKVRTTILAPSEFIGAIMELCQGKRGTLLGMDYLSEERVEMRYTLPLAEVVFDFFDQLKSRTRGYASLDYEPDGDQVADLVKVDILLQGETVDAFSAIVHKDKAYGYGLMMAGKLKELIPRQQFEVPIQAAVGARVIARENIRAIRKDVLAKCYGGDISRKRKLLEKQKAGKKRMKNIGSVEVPPEAFIAALTSDGAGAQATKK
>NZ_CP049935.1|WP_166121000.1|1746365_1746884_+|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MQWQRVLRPILDTAARGLRRSGTRPQSGPTTSRTPHPGGGYPGDYTGPLEPEYAPNPDGRPDPGEVVWTWVPYEEDHGQGKDRPVLVVGRDGRWLLALQLTSQDHDRDAGQERAAGRLWVDVGSGAWDTRGRPSEVRVNRVIRVDPDRVRREGAVLPRDRFDAVAEAVRRAT

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Crispr_ID: NZ_CP049935_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049935_4

1906186-1906314

Orphan

Consensus_repeat	Method
CGGTTCGAGGTGATGGCGCACCCTCTCGGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049935_4

>merge|NZ_CP049935|4|1906186-1906314|CRISPRCasFinder
CGGCTGGCGCTGAGGCCGCGGCCTCTCGGCCATCCGGTTCGAGGTGATGGCGCACCCTCTCGGGGTCCGCCTCCACCTCGAACGGTGGGAGGGCCACGCGGTTCGAGGTGATGGCGCACCCTCTCGGGG

>NZ_CP049935|4|4|1906186-1906314|CRISPRCasFinder
CGGCTGGCGCTGAGGCCGCGGCCTCTCGGCC	ATCCGGTTCGAGGTGATGGCGCACCCTCTCGGGGTCCGCCTCCACCTCGAACGGTGGGAGGGCCACG
CGGTTCGAGGTGATGGCGCACCCTCTCGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049935.1\|WP_166121317.1\|1914044_1915022_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP049935.1\|WP_166121309.1\|1903709_1904330_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166121325.1\|1921058_1922900_-\|malto-oligosyltrehalose-trehalohydrolase	unknown	unknown	gnl\|CDD\|274114
NZ_CP049935.1\|WP_166121319.1\|1915018_1916596_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166121294.1\|1893331_1894444_-\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP049935.1\|WP_166121303.1\|1898333_1899296_+\|mechanosensitive-ion-channel-family-protein	unknown	unknown	gnl\|CDD\|366370
NZ_CP049935.1\|WP_166121289.1\|1891550_1892108_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225408
NZ_CP049935.1\|WP_166121315.1\|1910832_1912296_+\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP049935.1\|WP_166121328.1\|1927792_1928548_+\|3-oxoacyl-ACP-reductase-FabG	unknown	unknown	gnl\|CDD\|187594
NZ_CP049935.1\|WP_166121312.1\|1904326_1904773_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|238329
NZ_CP049935.1\|WP_166121331.1\|1928738_1929644_+\|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380141
NZ_CP049935.1\|WP_166121322.1\|1917208_1921006_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|237171
NZ_CP049935.1\|WP_166121286.1\|1890125_1891100_+\|DUF389-domain-containing-protein	unknown	unknown	gnl\|CDD\|129372
NZ_CP049935.1\|WP_166124321.1\|1912334_1913297_+\|acyl-CoA-thioesterase-II	unknown	unknown	gnl\|CDD\|224857
NZ_CP049935.1\|WP_166121334.1\|1929815_1930961_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173849
NZ_CP049935.1\|WP_166121297.1\|1894560_1895031_-\|ribose-5-phosphate-isomerase	unknown	unknown	gnl\|CDD\|235509
NZ_CP049935.1\|WP_166121336.1\|1931726_1932773_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166121291.1\|1892619_1893369_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NZ_CP049935.1\|WP_166121306.1\|1902858_1903728_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341045
NZ_CP049935.1\|WP_166121300.1\|1895794_1898347_+\|aminopeptidase-N	unknown	unknown	gnl\|CDD\|274121

Protein	Function_ID	Function_description	E-value
NZ_CP049935.1\|WP_166121317.1\|1914044_1915022_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	2.68634e-94
NZ_CP049935.1\|WP_166121325.1\|1921058_1922900_-\|malto-oligosyltrehalose-trehalohydrolase	gnl\|CDD\|274114	TIGR02402, Malto-oligosyltrehalose_trehalohydrolase, malto-oligosyltrehalose trehalohydrolase. Members of this family are the trehalose biosynthetic enzyme malto-oligosyltrehalose trehalohydrolase, formally known as 4-alpha-D-{(1->4)-alpha-D-glucano}trehalose trehalohydrolase (EC 3.2.1.141). It is the TreZ protein of the TreYZ pathway for trehalose biosynthesis, and alternative to the OtsAB system. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NZ_CP049935.1\|WP_166121294.1\|1893331_1894444_-\|serine/threonine-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.13736e-30
NZ_CP049935.1\|WP_166121303.1\|1898333_1899296_+\|mechanosensitive-ion-channel-family-protein	gnl\|CDD\|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	4.20671e-44
NZ_CP049935.1\|WP_166121289.1\|1891550_1892108_-\|hypothetical-protein	gnl\|CDD\|225408	COG2852, COG2852, Very-short-patch-repair endonuclease [Replication, recombination, and repair].	0.00308567
NZ_CP049935.1\|WP_166121315.1\|1910832_1912296_+\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	5.02799e-80
NZ_CP049935.1\|WP_166121328.1\|1927792_1928548_+\|3-oxoacyl-ACP-reductase-FabG	gnl\|CDD\|187594	cd05333, BKR_SDR_c, beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs. This subgroup includes the Escherichai coli K12 BKR, FabG. BKR catalyzes the NADPH-dependent reduction of ACP in the first reductive step of de novo fatty acid synthesis (FAS). FAS consists of four elongation steps, which are repeated to extend the fatty acid chain through the addition of two-carbo units from malonyl acyl-carrier protein (ACP): condensation, reduction, dehydration, and a final reduction. Type II FAS, typical of plants and many bacteria, maintains these activities on discrete polypeptides, while type I FAS utilizes one or two multifunctional polypeptides. BKR resembles enoyl reductase, which catalyzes the second reduction step in FAS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet) NAD(P)(H) binding region and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H) binding pattern: TGxxxGxG in classical SDRs. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P) binding motif and an altered active site motif (YXXXN). Fungal type type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P) binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr-151 and Lys-155, and well as Asn-111 (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	1.01052e-103
NZ_CP049935.1\|WP_166124321.1\|1912334_1913297_+\|acyl-CoA-thioesterase-II	gnl\|CDD\|224857	COG1946, TesB, Acyl-CoA thioesterase [Lipid metabolism].	8.44881e-106
NZ_CP049935.1\|WP_166121331.1\|1928738_1929644_+\|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	gnl\|CDD\|380141	pfam18741, MTES_1575, REase_MTES_1575. Vsr REase Fold. Fused to HEPN (SWT1/Abi2 family), along with Transglutaminase and wHTH.	0.00039598
NZ_CP049935.1\|WP_166121322.1\|1917208_1921006_-\|FtsX-like-permease-family-protein	gnl\|CDD\|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	9.21229e-12
NZ_CP049935.1\|WP_166121286.1\|1890125_1891100_+\|DUF389-domain-containing-protein	gnl\|CDD\|129372	TIGR00271, Uncharacterized_protein_MJ0678, uncharacterized hydrophobic domain. This domain is in a family of archaeal proteins that includes AF0785 of Archaeoglobus fulgidus and in several eubacterial proteins, including the much longer protein sll1151 from Synechocystis PCC6803.	4.43586e-32
NZ_CP049935.1\|WP_166121312.1\|1904326_1904773_-\|acyl-CoA-thioesterase	gnl\|CDD\|238329	cd00586, 4HBT, 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites. There is no evidence to suggest that 4HBT is related to the type I thioesterases functioning in primary or secondary metabolic pathways. Each subunit of the 4HBT tetramer adopts a so-called hot-dog fold similar to those of beta-hydroxydecanoyl-ACP dehydratase, (R)-specific enoyl-CoA hydratase, and type II, thioesterase (TEII).	1.31655e-19
NZ_CP049935.1\|WP_166121334.1\|1929815_1930961_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173849	cd01160, LCAD, Long chain acyl-CoA dehydrogenase. LCAD is an acyl-CoA dehydrogenases (ACAD), which is found in the mitochondria of eukaryotes and in some prokaryotes. It catalyzes the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of LCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. LCAD acts as a homodimer.	6.5216e-151
NZ_CP049935.1\|WP_166121297.1\|1894560_1895031_-\|ribose-5-phosphate-isomerase	gnl\|CDD\|235509	PRK05571, PRK05571, ribose-5-phosphate isomerase B; Provisional.	2.15111e-68
NZ_CP049935.1\|WP_166121291.1\|1892619_1893369_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	1.6534e-59
NZ_CP049935.1\|WP_166121306.1\|1902858_1903728_+\|MFS-transporter	gnl\|CDD\|341045	cd17502, MFS_Azr1_MDR_like, Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.8787e-12
NZ_CP049935.1\|WP_166121300.1\|1895794_1898347_+\|aminopeptidase-N	gnl\|CDD\|274121	TIGR02412, Aminopeptidase_N, aminopeptidase N, Streptomyces lividans type. This family is a subset of the members of the zinc metallopeptidase family M1 (pfam01433), with a single member characterized in Streptomyces lividans 66 and designated aminopeptidase N. The spectrum of activity may differ somewhat from the aminopeptidase N clade of E. coli and most other Proteobacteria, well separated phylogenetically within the M1 family. The M1 family also includes leukotriene A-4 hydrolase/aminopeptidase (with a bifunctional active site).	0

>NZ_CP049935.1|WP_166121312.1|1904326_1904773_-|acyl-CoA-thioesterase
MAATYVVDVPLRWSDMDAYGHVNNVQYLRLLEDARVIGFREWFPDRPALVDEGIVVTRHVIEYRAPLTYRPEPVEVAMWVTRVHGAGFDLGYVVRDPASVGEGTYAVAETGLALYDFATARPRRLEAGAREALAVHVGDPVTFRRAGR
>NZ_CP049935.1|WP_166121309.1|1903709_1904330_-|hypothetical-protein
MSDLLRLVDAAALGDLGRYAARARALDEQGAMRLQAAGEVLAAWVGVLPGSGILAEGTVLGLRTFALAEPATCDVVVPLGAVTDRTARHGGTGDLPLPPTRAIATWSAVTPPRSGWEPAGEVAADELAETARSGLVEVGAAVRERGAAAGFVRDRVWSREAVAGVRAGGAFAAFSLGFLAPGSTVRVLRSNRWTRLSAAGGHVLMR
>NZ_CP049935.1|WP_166121306.1|1902858_1903728_+|MFS-transporter
MGVLGVVAPVVVTIFALAHARTRVDTSGLDAAVSGRDHSAHVRAAWAGVGVAVAAGALQYGTHELVFTWSVKTVVGVLGLLGVAAVAPVLLPRATWVMGAGLPSVVLARALLCAAFYGGITYVPLFLAGQRGASLQVAGLALAVGAVGWAVGAWYQGHDAMHLPRHRLVEIGGLVLTFGLIWLSVVAWANLPAWLSVLALLLAGLAMGGGVTTTTILALELSPVEEHGEASSSIQLADVLGSVLGIAGATAAFAAAHDPGQDNALFGAIFLGLALVAAVVVPAGQRIRT
>NZ_CP049935.1|WP_166121303.1|1898333_1899296_+|mechanosensitive-ion-channel-family-protein
MPVSDAVTALSTLDVSTLDAQVVANYWDKVQTWLLGDGIRVLVTLLMGLVARWALHRVIGRVVATMTSRTAARIADSGGAGRVLATATGLANERHRQRVETMGSLLRSISTFVVGTVTVLTVMALVGLPLGPLLASAGVGGVALGFGAQSLVKDFLSGIFMMLEDQYGVGDVIDTGEAIGTVEEVTLRVTRLRDADGIVWYVRNGEVIRIGNRSQGYSAAWVDMPVSYLEDIERVLGVVRDVAEAFGADPAWEEKLIEAPTVLGVDSITGQTVTVRVLAKCVAGENFGVQRELRARIKAAFDAHGIQGPPLPPFAPGARP
>NZ_CP049935.1|WP_166121300.1|1895794_1898347_+|aminopeptidase-N
MPGTNLTRDEAAARAALVTVDTIDVVLDVTTGPETFATTSTLRFACTTPGAETFLDFVGASVERITVNGTDLDPAEHFSDSRIRLTGLAADNEVVVEATGRFTNTGEGLHRFVDPVDDEVYLYTQFEVPDSRRMYPVFEQPDLKAAFAFTVTAPAHWQVVSNSPTPEPTPAAEGTATWAFERTPRLSSYITALVAGPYDVVRDSVATRGGEVPLGIFCRKSLTPYLDADNLFALTKKGFAFFEEEFDCAYPFAKYDQLFTPEYNAGAMENAGAVTIAEIYVFRSKVTEALVERRALTVLHELAHMWFGDLVTMRWWNDLWLNESFAEWASTTCQAEATEWTDAWTTFGTYEKDWAYRQDQLSTTHPIVADISDLRDVEVNFDGITYAKGASVLKQLVAYVGRDAFRDGLRTYFRKHSWGNTTLEDLLVELEATSGRDLRSWSRAWLETAGVNTLRPAVEVDEYGRITSAVIEQTHAEGYATLRPHRLGVGLYEVRDGALERTDLLEVDVDGARTEVPALVGRPQPDLLLVNDDDLAYAKIRLDERSLATALAHPRGFTSSLPRALVLASAWDMTRDAEMGARSFVDLVLASLPGESDSTLLRTLILQLRSAVLSYTAPAHRESTREATRDRLWEIARDAEPGSDAQLQLVTAAAGLTTAGDDPTTLRGLLDGTEVLEGLDVDFEMRWTLLTALAAAGAATEADIDAERAREDTATGRERAAKALASVPTAEAKERAWREAVEETGKPNAVVDAIGLGFARGATPPELLRPFVERYFTMLDTVEEKGSHALVEGIVLGFYPFPVVDAGLLEATQAWLDANPDRPAALRRLVAENRDPVARALAAQERDARE
>NZ_CP049935.1|WP_166121297.1|1894560_1895031_-|ribose-5-phosphate-isomerase
MARVHVGADHAAFEMLNDLVALLEAEGHEVTNHGPHEYDAEDDYPVFVLRAAEAVAADPEALGVVLGGSGNGEQMAANKVRGVRAALAYDEELARLAREHNDARILSIGARMSEPEVARAMVRTFVATPFSGEERHVRRLRMIEAYEADGTLPPVG
>NZ_CP049935.1|WP_166121294.1|1893331_1894444_-|serine/threonine-protein-phosphatase
MTAGAGRSGSRRVAVDGSRRLVFPNRFAGVDQGRWLVVALVVAVTLVGVGAVVRPDLVPISLLFPLLVVAGLLLEPRRLAIVLVGAGLVVFAWGPGSLLSPTRVAGVSVAVALVMWQAVLIARSRALLGTRGLGGDRMFAELRDRIVRGGQVPAMPEGWAATSCIRSAHGDRFSGDFVVAHLEGDGERFEVALVDVSGKGTAAGTRSLLLSGALGGLLGAVPPADFLRAANDYLVRQGWHEGFATAVHVELDLRSGLYSVASAGHPAPAVYTSGRARWTLMDGGRGPVLGVVPGVSFPRQSGRLERGDALLVYSDGVVEARDRDLVDGIDRMLGVAAASVLSGGDVARDVCESARSGEDDDRAALAVRRV
>NZ_CP049935.1|WP_166121291.1|1892619_1893369_-|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MTTGPPSRSAASDPSSHPERPLLVPARPDLDHTPREGVRTFTPRWRNSPLTDERMATLLPARALPEGPLVPVEAFGRSGPVVLEIGSGHGAAAIAYAAAHPEADVVAVDVHVPGIARMLAAADAAGVANLWVHAGDALPLLTERVAPGTLAAVHLFFPDPWPKQKHAKRRFVQQHTLSLLASRLAPGGVLLVATDIDSYAAHCRTQLAAHGGFDVVEGERPDWRPDDGFEAKGLRHGRGVSEFRCTLRP
>NZ_CP049935.1|WP_166121289.1|1891550_1892108_-|hypothetical-protein
MLGPVVRAGLPRARVEVATIRGAQWARTDREAALVVCLAVQQRLVHPARLLAAWAEVRGGRRHRVLDAVIRDVCDGAHSLGELDLSRMCRRAGLPAPDRQVVRRAPGGRLYLDAVWDDVGLVVEVDGAHHLLALAPVDDALRANEVVIGGERVLRLPVLALRLDPARCLDQVARARAALLARAAA
>NZ_CP049935.1|WP_166121286.1|1890125_1891100_+|DUF389-domain-containing-protein
MLSLRVTVPAHLSDEVVAVLDADDYVTGLAVLRGASVKPPGDVVTADVAREGANPVIEALRDLGVHEEGTIRVEAVTTWVSRAGLDAERRAPGASADAVVWTEVGNRAYEDSELNWTYLSFMALATLIAGIAIVLDSPILVIGAMVLGPEFGPIAALGLALVRRKWGLFGLAARTLVLGFAAGMVVTFVAGLVGRGLGWVTYEDIVGERPATAFIYTPDRWSFIVAVIAAAAGVLSLTSARTGGLSGVFISVTTVPAAGNVALGAAFGAWHEVTGSLAQLGLNLTGMAVAGWLTLSLQQAVWSRVPARRRTLVRGRPVVGRPED
>NZ_CP049935.1|WP_166121315.1|1910832_1912296_+|PLP-dependent-aminotransferase-family-protein
MNASAPTVSAARTARLVGDLATSRPTYRALADALRLAVADGRIPAGTRLPSERDLTGPLGVSRTTVTRAYDVLRETGYLTSRRGSGSVATLPAGTLRRGTGGLFPADVADGVIDLTCAATRAPAGVVEAYERAVARLPAYLCGAGYLTHGVPDLREAIAQRYRDRGLPTSADDVLVTSGAVAGLGVVVRALLRPGDRVVVEDPSYPNTVDALRAAGARLRPLVVDPDGWDVEEAERTLTAAAGRAAVLIPDFHNPTGALMPDEQRARLAHRLRTTGTTPVVDESIVEVDLDGGAAVLPFAAHAPEAVSIGSSSKSHWGGLRTGWVRAPRGALRSLVEARVSGDLGAPVLEQLVLAELMQRSPGLTAERRTDLVASRTALAEALAAELPDVRFRVPRGGLSLWCELPVGLSSTALTAAAEDEGLLVAAGPRFAVEGGLDRWLRLPHPLPPATMTEAVRRLARAAERVRSGRAAPGPARVARPGRPLVA
>NZ_CP049935.1|WP_166124321.1|1912334_1913297_+|acyl-CoA-thioesterase-II
MVARVTSEHPDPLTDLLETLDLEELGSAEVSVQPRDPAVPSGLVIPETLAEDITLFRGRSQKQPHGRVFGGQVLAQGVVASGRTVVGVGDEPRRLHSIHAYFMRPGDDTQPITFSVERMRDGRSFSTRRVHAIQHGKPILSMSASFQVPDRGLDHQDPAPQVPGPDTVPSLAELFAGVDDPRAQHLSRRAIELRHVEGNLFAAPPAEEVASQHVWMRAVGRLPDEPLVHDAVLAYASDYSLLEPVLRRHGLPWSTRGLKMASLDHAMWFHRPARADEWVLYAQESPSAQGGRGLGLGRMFAADGTLVATVAQEGMVRVPD
>NZ_CP049935.1|WP_166121317.1|1914044_1915022_-|ABC-transporter-ATP-binding-protein
MTTSPATTTRTRRRGDAGVPDGPDILCDNLVRIYRAEGLEVVALQGLDLEVQRGELVALVGASGSGKSTLLGILSGLDTPSAGLARVSGHDLGSMAGRERLEYRRRTVGFLFQQAAANLLPYLTAAENVELPMLLAGVRAGERATRARQTLEVLGIPDCADRRPGQLSGGQQQRVALGVAVANRPRVLLADEPTGELDTRSSDEVFEAIRLANTEFGTTVLVVTHDPLVSEQVARTVGIRDGRTSTEVLRRDEVGADGAVGRVAEEYAVLDRAGRLQLPKAFTASLEMRDRVRLGLEPDHIAVWPTGQPDGAGERGADGSGEERR
>NZ_CP049935.1|WP_166121319.1|1915018_1916596_-|hypothetical-protein
MPIVVLAVVPVLLLVTGTQGAGTWVEVALVALVPALAATAAVLLRVRSLEHDDSGEDAVRRARVVRVARRVVAELAVVAVAAAAVATVRSRGGEIAGGRTDWYAALTPVLVAAAAALLVLRLLPVPVRAAARVAARRRGLVGFLGLARAARTGATAALPVLAVVVGAAVLALLAALTSTIGEQREVSAWRTVGAEVRVDAVRVDADDAAALAARPGVRSVVRAYVATGATLVSGRRATPVLLLGVDPAEYGRLLADTPLHLGAPPAATGSGLTLLAGPGIATDGDLELAVRGSRVPVGRLVVDPGLARLAAGQSLPAVLVPLDDLGELVPSAQPNTAFLAADASAAEALRTLREPGTATPSGRVTGVDTVAAAEQRVAGRALPRLIARTYLVGALLAGVLTLLAVVLLLAATRPERAALVIRLRTMGLPHGGERGLAWTEVLPVVALAGLAGAVVGAAAPSLVEAAVDLAPFTGGAPHPALPVVPLAAAGAGVLVIVLGALALLLDAAAARRGRLADHLRKGDTA
>NZ_CP049935.1|WP_166121322.1|1917208_1921006_-|FtsX-like-permease-family-protein
MGGARLLRRRLGSHPVAVAAIAVSVLASLVVVTALQVLSAAITDAGVRSALVVPPAERSLVLSAALRPGDLAAVDAAFTRGVAGLPSSTVTRVGTATTRSLPGRATTDRALLADVRGIDGAARLTVGRWPVRPDDAAARGRGRVEVALPDAAADGLGVGVGDTLRLGDLIDPKAPVLTVEVVGTFLPRSPQDGLWADLPLGLEGVTESDFTTYGPFVVAAGTFDGPLVGSSTVTWRATPDLGGVRVGDVDRLSAQVDDAVTGLRRVVGLPLVEGSPETAQPPSVPAGSPRVVTALPALVDEAGLVGDRVRVSLLTPTVLLVLLGTVALVGAAALLAALRDTETRLLRTRGASTARLAGFALGDAVVVAALGVLGTSLAAPVLAHLVAGSDGPVWSVAAVRDPVLWRTALPLAVLAVVVTVLTTLWVGRARGGGGGRTRAGGLRLAAGSGLDVVLVLLGVLAAVQLRRYDAVGETTVDPLTTAAPALVVAGLSVVCLRLLPVLARVAAGWGARRPGLDAAWGGWQFARRAAGQSGTLLLVLLAVAMGTIALGHRATVDRAITDQSAFDTGSPVRVVREVSGPASAATGDLVDDAAGGAARVSPVWRGTVDLGGVSDVTVLGVDARAAATVMSPRPDTLDAPWSTVTDRLVRARDLGGGVPLPGSPQRLVVTAKVVTDSPLAVDGFAGSVRVRDARGLVSSVPLGPVSSTQRDLTADLRGLGLVPPLAVVGVSVPLPDYVYYFLPEPTFDLVVSGLTADGAPVALGNELRPSSDRLGLWQAARAGAARPVPAVVTRQVADALQVGAGRQVTLPLGVRDLSITVVSVVDSLPTAQVPARGILLDLPTVEATPERVGGGSDVRSRTVLDPQEWWAAPADPEAAARVVRAKAPYGTIVLVADEQVRERLADPVNAGMRSAMLLVTLASVLLAGVGFAASTAALGRARRHENAVLLALGMPPGRIRSVLVLERVLVVLVTVLVGLLLGVLAAVTVVPLLVGGDGHPQVPSVLVRLPVGSLAGYALLLLLALVVVGAAVLRSTSRDLAGELREGRRRDRSRTRTPRGAPARPGGGPERPVGPGAVVARSPRRPGAGRRPRPAGRGHRRLPRRHAAGRVGRRRRGRGRHRGRGPRPGPRDRAALRAGALARPSRTVRDPRGRAAGPLRGGRRGAARGRRARRHPPARNADLGRPERLRDHRPAGRHDAATRRLAGRRPRPERAGLARAVGHRGRPRGADHHALGRAPRQGPRHRRRARRPRRVHRQGLGRRGR
>NZ_CP049935.1|WP_166121325.1|1921058_1922900_-|malto-oligosyltrehalose-trehalohydrolase
MSVRVIEVWAPLAGRVELEWSPVPGPADGPPEVRREAMEPADGGWWQLALPEGTGPVDYAFVLDGADPALPDPRSAWQPAGVHGPSRTLDPADLVWTDDAWRGPRDGAGSLGAVFYELHVGTFTPEGTFDAAAAHLDHLVALGVDVVEVMPVAAFPTDRGWGYDGVGLYAVHDAYGGPHALARFVDACHARGLGVCLDVVHNHLGASGNYLSRFGPYFTEGHHTPWGAAVNLDDDGSAQVRRFLVESALRWFRDLHVDALRLDAVHELKDDSARHYLAELSEEVAALATDLGRPLDLVAESDLNDIVMVTATGDGGRGMTAQWDDDVHHALHVALTGEAQGYYADFAGAPDGPHPGPLSVLAKVLTHGFLHDGTHSSFRGATWGAPVDREGLDARRLLGYLQTHDQVGNRATGERISALVADPALQAAGAALYLLAPTTPMLFMGEEWAASTPWQFFTSFAEDWLADAVREGRRAEFGSHGWSADDVPDPQDPATRDRSVLDWSELGEPDHARMLRWYTDLTALRRRLLGSGPTRLADVEVDVDEEERWVLLRHRPAGGEPFAVVATLGGPAEVPLSGAGAPHLEWEPGRTSVGPTSVAHRCRSVSVHPLGPA
>NZ_CP049935.1|WP_166121328.1|1927792_1928548_+|3-oxoacyl-ACP-reductase-FabG
MSDQRVAVVTGAARGIGAATAERLARDGFAVAVLDLDEAACEEVAGRIRDAGGSAVGVGVDVSDAAAVAAGVARVADELGPPVVLVNNAGIIRDNLLFKMTEADWDAVMDVHLKGAFLMTKACSAHMTEQRYGRVVNLSSSSAQGNRGQANYSAAKAGLQGFTKTLAIELGKFGVTANAVAPGFIQTDMTRATAERLKVSFEDFITHTASTIPVARVGQPEDIAATISFLVSEEAGFVSGQVIYVAGGPLD
>NZ_CP049935.1|WP_166121331.1|1928738_1929644_+|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein
MDPVVSHLLAAQEGVVSRAQLVPRGVPPAVLAASVRDGGLVRIRPGLFADPARWVGAHPDERYRLTVRGVLLGRPGWAASHHAALALWRLPLWRTDLRVVDVLAGTHTAKIRPGTHVHVQGNVTAAVRDGCATAGPAVAAVQVAATAGAESGVVALDAALHRGLCTTDEVERVLAAGVVRYGTGRARRMLALADPACESVGETRTRLLLLALGHRPRSQVVIRDAHGVVGRVDLLVGRVVVEFDGALKYGGAEGRDALVAEKVREDRLRALGYVVVRLTWADLDHPARVAALVQRALAVAA
>NZ_CP049935.1|WP_166121334.1|1929815_1930961_-|acyl-CoA-dehydrogenase
MPRNVYASEHEDFRASVAEFVERTLKPRAEQMLEVKSVDRDLWKEAGKQGLFGLDIPEEFGGMGAEDYRFNAIAAEVIAGFNFAVSSCFGIHSDVCPPYVVDLGTQEQKERWLPGMANGELIAAIAMTEPSGGSDLAALKTTAVRDGDDWVLNGSKTFITNGYQADLVIVAARTDPSKGAKGITLLVVEEGMEGFSRGRKLDKVGQEEADTSELFFEDVRVPDANRLGEEGMGFIAMMQRLPQERIGAAVANTAHAFQIFRETVEYTKERKAFGQPVGSFQHNKFKMAELLTKLEVTQAYVDDCIAAHAEGKLTPVDAAKAKWFSAQVQNEVLDECVQLHGGYGFMNEYRVARAWRDARVSKIWAGSNEIMKELIGRDLGL
>NZ_CP049935.1|WP_166121336.1|1931726_1932773_+|hypothetical-protein
MSTTPRAPGVAKGLHPLADDPDLPASRQPTRLAEFLLGVVVLYAWAPPGVPGFLSLGLVGVAGLLGLSLVRPGGTRLGGPGGSLGWLAPGLVLLVGFLVLVSISSPDDSISGWPRRAFRLTMVLALLVAVVSGRVHWPSLVRGTAVGLLVNAALFFVGVAPAPYGEYLSGFLLDKNQAGLAYAVVTLLYLSLVDERRRQVAVVVVGAALVWTTGSRTSIAALACGLVWVVLRPRLGPAARVALAVALGIGVQVVENNFARAGVFASRDGSDAFRARIDAASQAKLAGSPRRASASGRRGSGSATGSTSSTTPTGRPSSRAAGCCSGPTCCSSSSPSASGGAVRSPTCG

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Crispr_ID: NZ_CP049935_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049935_5

2012581-2012669

Orphan

Consensus_repeat	Method
GTCGAGGTGAAAACGCACCACCAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049935_5

>merge|NZ_CP049935|5|2012581-2012669|CRISPRCasFinder
GTCGAGGTGAAAACGCACCACCAGGCGGCCCACCATCACCTCGAACGCGCAGCGTCCACCCGGGAGTCGAGGTGAAAACGCACCAGCAG

>NZ_CP049935|5|5|2012581-2012669|CRISPRCasFinder
GTCGAGGTGAAAACGCACCACCAG	GCGGCCCACCATCACCTCGAACGCGCAGCGTCCACCCGGGA
GTCGAGGTGAAAACGCACCAGCAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049935.1\|WP_166121462.1\|2013052_2013613_-\|YqgE/AlgH-family-protein	unknown	unknown	gnl\|CDD\|234694
NZ_CP049935.1\|WP_166121450.1\|2005668_2006907_-\|4-hydroxyphenylpyruvate-dioxygenase	unknown	unknown	gnl\|CDD\|273528
NZ_CP049935.1\|WP_166121476.1\|2029039_2029531_-\|SsrA-binding-protein-SmpB	unknown	unknown	gnl\|CDD\|376590
NZ_CP049935.1\|WP_166121448.1\|2004105_2005590_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|129987
NZ_CP049935.1\|WP_166121464.1\|2014942_2015770_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237171
NZ_CP049935.1\|WP_166121466.1\|2017889_2018519_+\|SIMPL-domain-containing-protein	unknown	unknown	gnl\|CDD\|225516
NZ_CP049935.1\|WP_166121478.1\|2029588_2030923_-\|peptidoglycan-DD-metalloendopeptidase-family-protein	unknown	unknown	gnl\|CDD\|366703
NZ_CP049935.1\|WP_166121446.1\|2003200_2004040_+\|DUF427-domain-containing-protein	unknown	unknown	gnl\|CDD\|377265
NZ_CP049935.1\|WP_166121474.1\|2026811_2026985_+\|CsbD-family-protein	unknown	unknown	gnl\|CDD\|283241
NZ_CP049935.1\|WP_166121456.1\|2009192_2009351_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166121460.1\|2012711_2013020_-\|DUF3039-domain-containing-protein	unknown	unknown	gnl\|CDD\|378609
NZ_CP049935.1\|WP_166121454.1\|2007495_2009196_-\|bifunctional-metallophosphatase/5'-nucleotidase	unknown	unknown	gnl\|CDD\|236506
NZ_CP049935.1\|WP_166121472.1\|2023247_2026667_+\|pyruvate-carboxylase	unknown	unknown	gnl\|CDD\|237263
NZ_CP049935.1\|WP_166121444.1\|2002313_2003120_-\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NZ_CP049935.1\|WP_166121470.1\|2019231_2021904_+\|pyruvate,-phosphate-dikinase	unknown	unknown	gnl\|CDD\|236446
NZ_CP049935.1\|WP_166121468.1\|2018515_2019130_+\|YgjV-family-protein	unknown	unknown	gnl\|CDD\|378474
NZ_CP049935.1\|WP_166121440.1\|1993824_1996716_+\|VCBS-repeat-containing-protein	unknown	unknown	gnl\|CDD\|379232
NZ_CP049935.1\|WP_166121458.1\|2011316_2012267_-\|zinc-metalloprotease	unknown	unknown	gnl\|CDD\|239802
NZ_CP049935.1\|WP_166121452.1\|2007014_2007506_+\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_CP049935.1\|WP_166121442.1\|2000633_2001086_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP049935.1\|WP_166121462.1\|2013052_2013613_-\|YqgE/AlgH-family-protein	gnl\|CDD\|234694	PRK00228, PRK00228, YqgE/AlgH family protein.	1.62371e-54
NZ_CP049935.1\|WP_166121450.1\|2005668_2006907_-\|4-hydroxyphenylpyruvate-dioxygenase	gnl\|CDD\|273528	TIGR01263, 4-hydroxyphenylpyruvate_dioxygenase, 4-hydroxyphenylpyruvate dioxygenase. This protein oxidizes 4-hydroxyphenylpyruvate, a tyrosine and phenylalanine catabolite, to homogentisate. Homogentisate can undergo a further non-enzymatic oxidation and polymerization into brown pigments that protect some bacterial species from light. A similar process occurs spontaneously in blood and is hemolytic (see . In some bacterial species, this enzyme has been studied as a hemolysin. [Energy metabolism, Amino acids and amines].	1.14973e-157
NZ_CP049935.1\|WP_166121476.1\|2029039_2029531_-\|SsrA-binding-protein-SmpB	gnl\|CDD\|376590	pfam01668, SmpB, SmpB protein.	1.50818e-81
NZ_CP049935.1\|WP_166121448.1\|2004105_2005590_+\|amino-acid-permease	gnl\|CDD\|129987	TIGR00909, putative_amino_acid_transporter, amino acid transporter. [Transport and binding proteins, Amino acids, peptides and amines].	7.16835e-115
NZ_CP049935.1\|WP_166121446.1\|2003200_2004040_+\|DUF427-domain-containing-protein	gnl\|CDD\|377265	pfam04248, NTP_transf_9, Domain of unknown function (DUF427). This domain contains a beta-tent fold.	1.12673e-31
NZ_CP049935.1\|WP_166121466.1\|2017889_2018519_+\|SIMPL-domain-containing-protein	gnl\|CDD\|225516	COG2968, COG2968, Uncharacterized conserved protein [Function unknown].	1.18139e-29
NZ_CP049935.1\|WP_166121478.1\|2029588_2030923_-\|peptidoglycan-DD-metalloendopeptidase-family-protein	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	5.7e-35
NZ_CP049935.1\|WP_166121464.1\|2014942_2015770_-\|hypothetical-protein	gnl\|CDD\|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	1.15653e-14
NZ_CP049935.1\|WP_166121474.1\|2026811_2026985_+\|CsbD-family-protein	gnl\|CDD\|283241	pfam05532, CsbD, CsbD-like. CsbD is a bacterial general stress response protein. It's expression is mediated by sigma-B, an alternative sigma factor. The role of CsbD in stress response is unclear.	3.11537e-08
NZ_CP049935.1\|WP_166121460.1\|2012711_2013020_-\|DUF3039-domain-containing-protein	gnl\|CDD\|378609	pfam11238, DUF3039, Protein of unknown function (DUF3039). This family of proteins with unknown function appears to be restricted to Actinobacteria.	6.18196e-34
NZ_CP049935.1\|WP_166121454.1\|2007495_2009196_-\|bifunctional-metallophosphatase/5'-nucleotidase	gnl\|CDD\|236506	PRK09420, cpdB, bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase.	1.8961e-129
NZ_CP049935.1\|WP_166121472.1\|2023247_2026667_+\|pyruvate-carboxylase	gnl\|CDD\|237263	PRK12999, PRK12999, pyruvate carboxylase; Reviewed.	0
NZ_CP049935.1\|WP_166121470.1\|2019231_2021904_+\|pyruvate,-phosphate-dikinase	gnl\|CDD\|236446	PRK09279, PRK09279, pyruvate phosphate dikinase; Provisional.	0
NZ_CP049935.1\|WP_166121468.1\|2018515_2019130_+\|YgjV-family-protein	gnl\|CDD\|378474	pfam10688, Imp-YgjV, Bacterial inner membrane protein. This is a family of inner membrane proteins. Many of the members are YgjV protein.	0.000208877
NZ_CP049935.1\|WP_166121440.1\|1993824_1996716_+\|VCBS-repeat-containing-protein	gnl\|CDD\|379232	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	3.84505e-06
NZ_CP049935.1\|WP_166121458.1\|2011316_2012267_-\|zinc-metalloprotease	gnl\|CDD\|239802	cd04275, ZnMc_pappalysin_like, Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. This model includes pappalysins and related metalloprotease domains from all three kingdoms of life. The three-dimensional structure of an archaeal representative, ulilysin, has been solved.	7.46259e-94
NZ_CP049935.1\|WP_166121452.1\|2007014_2007506_+\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	2.12367e-25
NZ_CP049935.1\|WP_166121444.1\|2002313_2003120_-\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	2.08586e-20

>NZ_CP049935.1|WP_166121458.1|2011316_2012267_-|zinc-metalloprotease
MRTRSLTALAALTLGVAGALVPATASQARPMTADTAASAQCETHSDAVGGRHAKGPNRADPHELSDAEAAKLTARFERDMAAKGVGTAARTQARKPAAAFAATVIPVHWHVITDGSTGNLTASELAGQISVLNSAYSGSGFSFRTASTDYTNNATWYNGITDGTTAERNMKSALHIGGKGDLNLYTASLGGGLLGWATFPKASVDPMDGVVMLDESLPGGSAAPYNQGDTATHEIGHWLGLYHTFQGGCSGSGDSVGDTPAEASPAYGCPTGRDTCTASGVDPIKNFMDYTDDSCMNTFTAGQIARAQSLWTTYRA
>NZ_CP049935.1|WP_166121456.1|2009192_2009351_-|hypothetical-protein
MTDTSFSAATRRQLLTLAAVGGAGVLSAPRRAPTTATTPATDTATGTGRPPA
>NZ_CP049935.1|WP_166121454.1|2007495_2009196_-|bifunctional-metallophosphatase/5'-nucleotidase
MTVLGTTDLHGNVYNWNYFANKAYSDAKGNEIGVAKAATLIKAMREERGADRCITLDAGDTIQGTPLAYYYAKIDPITGGAKHPMATAMNAVGYDAAALGNHEYNYGLDTLRAFERQCRHPLLSANSVDWNTRRPIFRPYVMKRIHVRGQKPVTVGILGLVTPGVAIWDAANVEGKVRFPGIVEQAKVMVPRMKREGADVVVVSCHSGATTSSSYGDALPYPENASSLLAAQVPDIDAILVGHAHVEIPQQFVTNEKTGRKVLLTEPLYWGMRVAVMDLDLEQVRGRWQVTKAAGSLLNANKAPEDPRIAALVRPAHEKVLTYVNSVIGTSTEAMSASTSRYQDTAAMDFINLVQGQAVEDALVGTPQAGLPVLSIAAPFNKDAAIPAGDVTVRDVAGLYIFDNTLLGITLTGAQVKAYLEWSARYFKKVTGAGPFTADQVTNAVTDTAPGGTPDYNYDIMGGLDAPLTYDIDIAQDPGARITNLQYAGAAIDPAQQFVIAINNYRQSGGGNFPDVKSAPVVYNRQVEIRQLLIDWVTAKGTIDPPAFASTDWRLTSGGAPVVVTG
>NZ_CP049935.1|WP_166121452.1|2007014_2007506_+|Lrp/AsnC-family-transcriptional-regulator
MARQDGVDPLDARIIALWTEDPHVGVLGASRALGVARGTVQARLDRLQERGVIRSFAPQVEPAALGYPVTAFCTLEISQRQGHEPVVAHLSAIPEVLEIHSITGVGDLVVRVAARDNADLGRVIDEIIDDVHVLRANTAICLVTHLAHRTGPLVESAARSVSP
>NZ_CP049935.1|WP_166121450.1|2005668_2006907_-|4-hydroxyphenylpyruvate-dioxygenase
MTDTTTTSASHLDLTEQERQAGLDLQQLKQLVGLVEYDELQDPFPVTGWDAIVFVVGNATQTAHYYQSAWGMELVGYTGPEHGVRDHKAYVLKSGSIRFVVKGAVTPDSPLIAHHAAHGDGVVDISLEVPDVDRCIEQARRAGATVLQEPEDLTDEHGTVRVGAIATYGETRHSLVQRVVDGVTYDGPYLPGYVPASSTFVKRDGSPKRLFQALDHIVGNVELGRMDEWVGFYNKVMGFVNMAEFIGDDIATDYSALMSKVVANGNHRVKFPLNEPAVAKKKSQIDEYLEFYAGPGAQHLALATNDILTTVDQLRAEGVEFLDTPDAYYEDAELRARIGEVRVPIEELQSRKILVDRDEDGYLLQIFTKPLGDRPTVFFEIIERHGSLGFGKGNFKALFESIEREQDKRGNL
>NZ_CP049935.1|WP_166121448.1|2004105_2005590_+|amino-acid-permease
MSDDSSVLRTKPVEDVLAQAGGPDGEGGDDGHGPGRLTRRLGPFDLMGFGIGIVIGTGIFTLTGIEAKNHAGPGVVVSFLIAGAVSLLAALCYAELASAVPTAGSAYTYAYATIGEVFAWIIGWDLILEFALGASVVARGWSGYLQELFDLPTSVFGEGSVVNVGAIAIVLLLGVVAVVGIRESARVTNTLVVVKVAVCIFVIVAGAFYVKAANLSPFIPPARPVEEGTSGLKQPVSQALFGIEPTAFGFAGVLTAAAVVFFAYTGFEAVANLGEETRKPSRDLPLGLLGTLAVCTVLYVGVSLVITGMVPYDELNEGAPIASAFEAVGAGWASTLVSIAAVAGLTSVILVDLVAMGRIGFSMGRDGLIPRSVAAVHPRWGTPWKITMMTVVLVAVLAGFVPLTALADLVSIGTLFAFVVVSIAVPILRRTKPDLPRPFRTPFSPVVPVVSALACVYLMSNLSLETWLRFAIWMVLGFLVYFLYGRRHARLNAS
>NZ_CP049935.1|WP_166121446.1|2003200_2004040_+|DUF427-domain-containing-protein
MALRLGAHLDSLTDRLRWEPVTRRVRARLDGRPVLDTTDAVLVWEPRRVVPMYAVPPADLSATLAPRARAAVPDDLPPELGPVHFEWHHTPGTSFDVVVGERTLAHAAFAPDDPDLGGRVVIEWDPFDWTEEAQAVTGHPHDPFKRIDLLATERHVVVSLGGVVLADTHRALALYETHLPPRWYVPHDDVVTDLLVGSPTTSTCAYKGHAAYVSLRPGAVPGLDEEAGHDVAWTYPHPLHEVEAVRGMFCFWAERTDLEVDGVAVPRPATPWSAGLEPA
>NZ_CP049935.1|WP_166121444.1|2002313_2003120_-|RDD-family-protein
MSTPTAAGWYDDPDDPSQLRYFDGVVWSSHTTSRVSPTAASSTIGHSPDVRPAAERHQGEHGWQQGAARPEAGSGWSSAPGASSVRPGERRLPDGAVLAEWWRRLLARVVDAIIVNIVGGLLSLPFLGPLLDAFDTWFSAALEGGTGSQPDPAVIQAAVAEVALPVTLVGLAVALVYEVGFLVWRSATPGKMLLGTVVRPVEAAGPVTLPVALRRQAIKVVSELLSLNALLGLAGFLLSVVDPAWLLRDPRRQTLHDKVAETVVVLKR
>NZ_CP049935.1|WP_166121442.1|2000633_2001086_+|hypothetical-protein
MAEGDAVVAKYRTGPTPTWPWPDEHDLAAFLCAAAAAPVPFKLTGGLHHAVRGTYRVDGVPEENHGVLDVLVATAAALDGASTDTVAALLAVRDSGALTELVLAWSGDTTARVRAAFTAYGCCTVTDPLGELADLGLPTAPDRPGRTDAP
>NZ_CP049935.1|WP_166121440.1|1993824_1996716_+|VCBS-repeat-containing-protein
MAPASGAEVGSAAPASAHAAAAGADGLTEASAAGLAVKQKKDVVVTGLTTETSQTVAHANGTFTVTTSPRAVRTRTASGWVPIDNTLVRDGNRVRPRAAALPMTFSAGGSGALATLGAEKRTLSFGWPGVTLPTPVLDGDRATYPEVLPGVDLVLTADTDTFSEVLVVKNRTAAANPALRSLRFSVAAPGLRLRAGNGGVQAVDPSGRPVFASAQPQMWDSSGPQTTAELAAKPSARATVAGRGASDRLMSAGAGSRSRPMTTRLSGGHLDVVPDRSLLTGAGTTFPVQIDPAWSGGKVAWGYVDKKYPTVSYYNSTGDARVGYESQEGTTKRSFFHMKTTGFAGTSVLSATFRLNETWSWSCTAREMQVWATNSITSKTTWNTQPTWAYKQSAKTFAYNWYPSGQASPCPNPSGGVEFDVKTQATNAAKGSWSYMAIGIRAASETDTYAFKRFQNNPTLSVTYDNLPTTPTSATTVPYTACTGGSIGNTDISLRAVPQDKDGGSVIAEFRYGTTSTPTTVRQVAATAGKPAVLDLKRTLGAGKWYWEVRTVAKDANGTSRWSLPTSTCSFTVDLTAPNPAAVTVTSPTFPDYSENPDSVQGSAGRPAVFTITTPADAVYVRLAFDRDPIYRSPVTAGKAVVTMMPTRTGPSTLNVQLVDAAGNLSGINNSFDILAGPVPSGTPYTRGDLNSDGKPDILRWYQDSLICDYLGSGAIGNSATTFSAGSGCAVTSNADLGAGSKAVDVGNWDGVFDDTETNDVVTLTGGKLRLFRGNGAGGVDTTVVEDLTDDDLLNPTVFDASPYVEVYGAGDWDSDGDPDLAARTPDGRLWLLANDNGMVSVPDGTLGLEIGNIWTNYTAVFPGDVNGDGRVDILGRYNATGALYLYPGVVDGNGVGARTQIGSGWNVFSQIVPLDDWDRDGNVDWAGIQPDGDLYFYRGKSTTPFLNAAVLSGSGWTNNWVL
>NZ_CP049935.1|WP_166121460.1|2012711_2013020_-|DUF3039-domain-containing-protein
MSETMPPPSDPNAPQGEPGGPQTQTAVLERTETVPEVAEPGDHERFAHYVRKEKILESALSGEPVTALCGKVWIPGRNPDRFPVCPTCKEIYEGLRPPEDGD
>NZ_CP049935.1|WP_166121462.1|2013052_2013613_-|YqgE/AlgH-family-protein
MSPSHATGKLLVATPQIEEGVFHRSVVLVLHHGDDGAQGLVLNRPIEAGIEAVLPGWEEHASRPATMFQGGPVQLDSALGLVAVPGDPPDPTGVRRLFGGVALVDLDTPPVLVAPELTGLRIFAGYAGWSPGQLEEEIATGSWFVVEGEGRDAFTDHPHDLWQHVLRRQREPLRWMAWYPPDPTLN
>NZ_CP049935.1|WP_166121464.1|2014942_2015770_-|hypothetical-protein
MNIPMPKKASGPKARWTAAQKAEKRKGPKKPHRGQAVTKTGRPAAGPGRPADGEERAKRPRAERSARWDREDPRRGGKPSRAERREDLPARTERDERPRREERSDRPARVERTERPRFDRDDRPRREERTERPRFERTERPRFDRDDRPRREERTERPRVERTERPRFDRDDRPRREERTERPRFDRDERPARAERHVHRPHDERPRRERGDRPVRDRAPASPTPCAATATRAGTPTARGSATSVPARSRTPRPSVPRPTPGPPTAPPRPAVRSR
>NZ_CP049935.1|WP_166121466.1|2017889_2018519_+|SIMPL-domain-containing-protein
MSDHVEVIGTGTASASPDVVVLDVRVAVDARDVASALAALATRLDATVAAAADHGVAEHDRRTTGMGVSPRWDREGQSVTGYTAHQALRLRVRERARVSDVIAALAGAAGDALAVDNVSLEVADPSPLLVRARAAAFADASTRARQYADLAGRSLGPVLALSEVGPDSGPAPMPKMRFAAMDAGGGVPVEGGESSVSAGVVARFALGPA
>NZ_CP049935.1|WP_166121468.1|2018515_2019130_+|YgjV-family-protein
MSWVDALGWFGSALLVFSLLQARILRLRVLNTVACVILTVFNAVLGVWPMVAMNVVLAGINLFFIARMVRERGDDRAYAVLAVREDDSYLGHFLAVHGADIERFFPDFAAAPADGRSTYLVQHGDETAGVIAVRDAGDGTAQVELDYVTPRFRDFAPGEFVFRRSGLFRDRGYARVLTAPGMVAPYYDRLGFTRDGDRYRLELA
>NZ_CP049935.1|WP_166121470.1|2019231_2021904_+|pyruvate,-phosphate-dikinase
MTDFVRDFETGSMEEKDLLGGKGANLAEMTRLGIPVPPGFTLTTDACRHYLATGSVPDGLWDEVATHVAALEARTGRRLGDPVDPLLVSVRSGAKFSMPGMMETVLDIGLGDRSVDGLAAQIGDPRFAWDSYRRLVQMYGKTVLGLDGERFEDALDAAKAAKGVTADVDLDADDLRALVATYTAVVAEDSGAPFPQDPGEQLRGAVLAVFRSWNSDRAVLYRRRERIPADLGTAVNVQAMVFGNRGATSGSGVAFTRDPATGAPGVYGDYLQDAQGEDVVAGIRNTLTLADLERLDRPSYDELLAIMARLEGHYRDMCDIEFTIEQGRLWMLQTRVGKRTAAAAFRIAVDLVDEGVISEEEALLRVTGGQLAQLMFPHFDPTGARSLLATGMSASPGAAVGAAVFDSDTAVRMAAEGTPVILVRRETTPDDLHGMVAAAGILTSRGGKTSHAAVVARGMGRTCVCGAETLEVDTRAGLFTTHDGTVVRQGEVLSIDGSTGEVFLGEVSVRPSPVVRYFEGSASVDEGGPVVAAVDRLMSVADKHRRMQVRANADTAEDAARARRFGAEGIGLCRTEHMFLGTRRELVERLILAEGPADRQAVLDELLPLQRSDFVEIFEAMDGLPVTVRLLDPPLHEFLPDFTELSVKVAVAEATGAPHDTDSLLLLAVHRLHEENPMLGLRGVRLGIAIPGLFEMQSQAVLEAAALVNERGGHARPEIMVPLVGAVEELRAIRTEIDDAADRARRKHSVPLEHLVGTMIELPRAALTAGAIAEAADFFSFGTNDLTQTTWGFSRDDVESSFFSRYMEAGILGVSPFETIDPQGVGRLVRIGTDEGRAAKPGLKVGVCGEHGGDPESVRYFEERGLDYVSCSPFRVPVARLEAGRAVVGG
>NZ_CP049935.1|WP_166121472.1|2023247_2026667_+|pyruvate-carboxylase
MFQKILVANRGEIAVRAFRAATELGAKTVAVFPHEDRTSEHRLKADESYEIGEVGHPVRAYLDHDNIVRVAVECGADAVYPGYGFLSENPDLAEACEAAGITFIGPPASALHLAGNKARAIAAAREAGLPTLRGAEPTTDLDALAAAADDIGFPVFVKAVSGGGGRGMRRVDDPSTLRDSLEAAQREADAAFGDPTLYLEQAVVRPRHIEVQVLADGTGTVLHLFERDCSVQRRHQKVVEIAPAPDLDPELRARMCADAVQFAEAIGYRNAGTVEFLLGEDGRYVFIEMNPRIQVEHTVTEEVTDIDLVVSQMRIASGETFEDLGLRQEDIRTRGAALQCRITTEDPANGFRPDAGQITVYRSAGGGGVRLDGGTVFVGAQVSPHFDSMLVKLTCRGSDFETAVRRARRALAEFRIRGVSTNIPFLEAVLADPVFQRGEATTSFIDERPELLEARMGGDRGTRLLQYLADVSVNQPHGPVTTRLKPRTKLPALDREAPLPPGTRDLLQRVGPAEFARQLRERTDVPVTDTTFRDAHQSLLATRMRTRDLLHVAGHVSRTTPQLLSMEAWGGATYDVALRFLHEDPWERLALLREAMPNIPLQMLLRGRNTVGYTPYPTKVTDAFVHEAARTGLDIFRIFDSLNDVSQMRPAVDAVLDTGTAVAEVALCYTGNLMDPGETLYTLDYYLRLAEQIVDTGAHVLAIKDMAGLLRAPAAHRLVTALRENFDLPVHLHTHDTAGGQVGTLLAAIDAGVDAVDAATATMSGTTSQPSLSALVAATDGTARETGLDIDAVFALEPYWEAVRRIYRPFESGLASPTGRVYFHEIPGGQLSNLRQQAIALGLGDRFEDVEDMYAAANRILGNIVKVTPSSKVVGDLALALVGAGADPDDFEQNPTRYDVPDSVLGFLAGELGDPPGGWPEPFRTKALQGRQAKPRVTELTDEQEAALVTDTRRTLNQLLFPGPTREFEETRDVYGDLSVLGTIEFLHGLEQGVEYEAEIEAGKRLLLGISSVGEVDRQGMRVVMCTLNGQFRPVQVRDRSVEAETKAAEKADPSDPGHVAAPFAGVVTPTVAEGDTVEPGGVVATIEAMKMEASITSATGGTVRRLAIVGHQQVEGGDLVLVVGQGAPAPAGEAEAAD
>NZ_CP049935.1|WP_166121474.1|2026811_2026985_+|CsbD-family-protein
MGLGDKIENIKDDLTGKGKEAAGKATDNERLEAEGKGEQATSDLKQAGENVKDAFKH
>NZ_CP049935.1|WP_166121476.1|2029039_2029531_-|SsrA-binding-protein-SmpB
MAKDSGRDPGKKLVASNRKARHDYLVEDTYEAGLVLMGTEVKALRMGRASLVDGWAGFDRDDELWLEGVHIPEYVSGTWTNHTPRRRRKLLLHRRELDKIAQATRESGYSVVPLSLYFLDGRAKVEIAVVKGKKAYDKRQALRERQDNREADRAIAARRRGED
>NZ_CP049935.1|WP_166121478.1|2029588_2030923_-|peptidoglycan-DD-metalloendopeptidase-family-protein
MGRPDRARAAAPRRAMGALAALLCAVVTVTLAAPSAPAATDPGDRKRTVDRKIDNLKDHLEDTSAALSKAYSSLKDTQDKLPAARDALDKARQAAVAADQAEAEATQQLEVAKANESKAQGDLEKATDEVAAGRKRLAQFAAQIYQQQGFGQLDVALSSTEPQDFADRLAMVDTVLDVQNRTMERLSTEQAGLTALEDHLSALRVDSDRKQKAAAAALKRAQAARQAAVQAQADLEALAATQTKAAKGYEDQLAADKKQLASMQAEAARLQKILAARAAAARAKAAAEAKKHPHNGGGGGGGGGGTSNGAGVLSRPVRTGWVSSEFGMRFHPIYHYWKLHSGRDYAVNCGTPVYAAAGGTVISAGWGGGYGNRVVIDHGLERGVGLASTYNHLSRIVVGGGHVSRGQLIAYSGTTGTSTGCHLHFETLENGNFVNPRKWLNTLS

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Crispr_ID: NZ_CP049935_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049935_6

2467810-2467991

Unclear

Consensus_repeat	Method
CCTCCCGACTCCCCTCGGGTGCGCTGGCGCGCCCCCGACGGGAA	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP049935_6

>merge|NZ_CP049935|6|2467810-2467991|PILER-CR
CCTCCCGACTCCCCTCGGGTGCGCTGGCGCGCCCCCGACGGGAACCGTCGGCCTCACTGCGTTCGGCCTCCTCCCGACTCCCCTCGGGTGCGCTGGCGCGCCCCCGACGGGAACCGTCGGCCTCACTGCGTTCGGCCTCCTCCCGACTCCCCTCGGGTGCGCTGGCGCGCCCCCGACGGGAG

>NZ_CP049935|6|1|2467810-2467991|PILER-CR
CCTCCCGACTCCCCTCGGGTGCGCTGGCGCGCCCCCGACGGGAA	CCGTCGGCCTCACTGCGTTCGGCCT
CCTCCCGACTCCCCTCGGGTGCGCTGGCGCGCCCCCGACGGGAA	CCGTCGGCCTCACTGCGTTCGGCCT
CCTCCCGACTCCCCTCGGGTGCGCTGGCGCGCCCCCGACGGGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049935.1\|WP_166122092.1\|2477566_2478511_-\|MazG-family-protein	unknown	unknown	gnl\|CDD\|236569
NZ_CP049935.1\|WP_166122088.1\|2474279_2475143_-\|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|379128
NZ_CP049935.1\|WP_166122074.1\|2466736_2467567_-\|Bax-inhibitor-1/YccA-family-protein	unknown	unknown	gnl\|CDD\|378959
NZ_CP049935.1\|WP_166122072.1\|2466398_2466740_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166122084.1\|2472243_2472921_-\|septum-formation-initiator-family-protein	unknown	unknown	gnl\|CDD\|368217
NZ_CP049935.1\|WP_166122078.1\|2469069_2469402_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP049935.1\|WP_166122086.1\|2472947_2474237_-\|phosphopyruvate-hydratase	unknown	unknown	gnl\|CDD\|234617
NZ_CP049935.1\|WP_166122061.1\|2455886_2457497_+\|carbohydrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|379528
NZ_CP049935.1\|WP_166122080.1\|2469901_2470594_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|225852
NZ_CP049935.1\|WP_166122076.1\|2468086_2469016_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166124361.1\|2455237_2455876_+\|VTC-domain-containing-protein	unknown	unknown	gnl\|CDD\|143622
NZ_CP049935.1\|WP_166124362.1\|2464489_2464882_-\|RidA-family-protein	unknown	unknown	gnl\|CDD\|100011
NZ_CP049935.1\|WP_166122063.1\|2457640_2458855_+\|amidohydrolase	unknown	unknown	gnl\|CDD\|349914
NZ_CP049935.1\|WP_166122067.1\|2460952_2461432_-\|DUF1992-domain-containing-protein	unknown	unknown	gnl\|CDD\|378159
NZ_CP049935.1\|WP_166122071.1\|2465087_2466311_+\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|181146
NZ_CP049935.1\|WP_166122090.1\|2475270_2476209_-\|pseudouridine-5'-phosphate-glycosidase	unknown	unknown	gnl\|CDD\|377251
NZ_CP049935.1\|WP_166122082.1\|2470769_2471858_-\|Ppx/GppA-family-phosphatase	unknown	unknown	gnl\|CDD\|223326
NZ_CP049935.1\|WP_166122069.1\|2461477_2462854_-\|cystathionine-beta-synthase	unknown	unknown	gnl\|CDD\|273464
NZ_CP049935.1\|WP_166122065.1\|2458866_2460894_-\|NADPH-dependent-2,4-dienoyl-CoA-reductase	unknown	unknown	gnl\|CDD\|239240
NZ_CP049935.1\|WP_166122094.1\|2478507_2479005_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP049935.1\|WP_166122092.1\|2477566_2478511_-\|MazG-family-protein	gnl\|CDD\|236569	PRK09562, mazG, nucleoside triphosphate pyrophosphohydrolase; Reviewed.	1.77745e-62
NZ_CP049935.1\|WP_166122088.1\|2474279_2475143_-\|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	gnl\|CDD\|379128	pfam13338, AbiEi_4, Transcriptional regulator, AbiEi antitoxin. AbiEi_4 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	4.36922e-07
NZ_CP049935.1\|WP_166122078.1\|2469069_2469402_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	1.64292e-18
NZ_CP049935.1\|WP_166122084.1\|2472243_2472921_-\|septum-formation-initiator-family-protein	gnl\|CDD\|368217	pfam04977, DivIC, Septum formation initiator. DivIC from B. subtilis is necessary for both vegetative and sporulation septum formation. These proteins are mainly composed of an amino terminal coiled-coil.	4.99193e-13
NZ_CP049935.1\|WP_166122074.1\|2466736_2467567_-\|Bax-inhibitor-1/YccA-family-protein	gnl\|CDD\|378959	pfam12811, BaxI_1, Bax inhibitor 1 like. The Bax-inhibitor-1 region of the receptor molecules is conserved from bacteria to humans.	4.31362e-80
NZ_CP049935.1\|WP_166122086.1\|2472947_2474237_-\|phosphopyruvate-hydratase	gnl\|CDD\|234617	PRK00077, eno, enolase; Provisional.	0
NZ_CP049935.1\|WP_166122061.1\|2455886_2457497_+\|carbohydrate-binding-domain-containing-protein	gnl\|CDD\|379528	pfam14262, Cthe_2159, Carbohydrate-binding domain-containing protein Cthe_2159. Cthe_2159 from Clostridium thermocellum is the first representative of a novel family of cellulose and/or acid-sugar binding beta-helix proteins that share structural similarities with polysaccharide lyases.	9.84487e-72
NZ_CP049935.1\|WP_166122067.1\|2460952_2461432_-\|DUF1992-domain-containing-protein	gnl\|CDD\|378159	pfam09350, DUF1992, Domain of unknown function (DUF1992). This family of proteins are functionally uncharacterized.	1.433e-19
NZ_CP049935.1\|WP_166124361.1\|2455237_2455876_+\|VTC-domain-containing-protein	gnl\|CDD\|143622	cd07750, PolyPPase_VTC_like, Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins. Saccharomyces cerevisiae VTC-1, -2, -3, and -4 comprise the membrane-integral VTC complex. VTC-2, -3, and -4 contain polyP polymerase domains. For S. cerevisiae VTC4 it has been shown that this domain generates polyP from ATP by a phosphotransfer reaction releasing ADP. This activity is metal ion-dependent. The ATP gamma phosphate may be cleaved and then transferred to an acceptor phosphate to form polyP. PolyP is ubiquitous. In prokaryotes, it is a store of phosphate and energy. In eukaryotes, polyPs have roles in bone calcification, and osmoregulation, and in phosphate transport in the symbiosis of mycorrhizal fungi and plants. This subgroup belongs to the CYTH/triphosphate tunnel metalloenzyme (TTM)-like superfamily, whose enzymes have a unique active site located within an eight-stranded beta barrel.	5.66934e-35
NZ_CP049935.1\|WP_166124362.1\|2464489_2464882_-\|RidA-family-protein	gnl\|CDD\|100011	cd06154, YjgF_YER057c_UK114_like_6, This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	2.96849e-49
NZ_CP049935.1\|WP_166122063.1\|2457640_2458855_+\|amidohydrolase	gnl\|CDD\|349914	cd05664, M20_Acy1-like, M20 Peptidase aminoacylase 1 subfamily. Peptidase M20 family, Uncharacterized subfamily of proteins predicted as putative amidohydrolases or hippurate hydrolases. These are a class of zinc binding homodimeric enzymes involved in the hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in the protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. Aminoacylase 1 (ACY1) breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as in the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	9.67869e-175
NZ_CP049935.1\|WP_166122080.1\|2469901_2470594_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|225852	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism].	1.34411e-38
NZ_CP049935.1\|WP_166122071.1\|2465087_2466311_+\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|181146	PRK07851, PRK07851, acetyl-CoA C-acetyltransferase.	0
NZ_CP049935.1\|WP_166122090.1\|2475270_2476209_-\|pseudouridine-5'-phosphate-glycosidase	gnl\|CDD\|377251	pfam04227, Indigoidine_A, Indigoidine synthase A like protein. Indigoidine is a blue pigment synthesized by Erwinia chrysanthemi implicated in pathogenicity and protection from oxidative stress. IdgA is involved in indigoidine biosynthesis, but its specific function is unknown. The recommended name for this protein is now pseudouridine-5'-phosphate glycosidase.	6.07864e-179
NZ_CP049935.1\|WP_166122082.1\|2470769_2471858_-\|Ppx/GppA-family-phosphatase	gnl\|CDD\|223326	COG0248, GppA, Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism].	1.47818e-76
NZ_CP049935.1\|WP_166122069.1\|2461477_2462854_-\|cystathionine-beta-synthase	gnl\|CDD\|273464	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase. Members of this family closely resemble cysteine synthase but contain an additional C-terminal CBS domain. The function of any bacterial member included in this family is proposed but not proven. [Amino acid biosynthesis, Serine family].	0
NZ_CP049935.1\|WP_166122065.1\|2458866_2460894_-\|NADPH-dependent-2,4-dienoyl-CoA-reductase	gnl\|CDD\|239240	cd02930, DCR_FMN, 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the flavin and iron-sulfur cofactors. Metabolism of unsaturated fatty acids requires auxiliary enzymes in addition to those used in b-oxidation. After a given number of cycles through the b-oxidation pathway, those unsaturated fatty acyl-CoAs with double bonds at even-numbered carbon positions contain 2-trans, 4-cis double bonds that can not be modified by enoyl-CoA hydratase. DCR utilizes NADPH to remove the C4-C5 double bond. DCR can catalyze the reduction of both natural fatty acids with cis double bonds, as well as substrates containing trans double bonds. The reaction is initiated by hybrid transfer from NADPH to FAD, which in turn transfers electrons, one at a time, to FMN via the 4Fe-4S cluster. The fully reduced FMN provides a hydrid ion to the C5 atom of substrate, and Tyr and His are proposed to form a catalytic dyad that protonates the C4 atom of the substrate and completes the reaction.	0

>NZ_CP049935.1|WP_166122074.1|2466736_2467567_-|Bax-inhibitor-1/YccA-family-protein
MANNPAFNRLEKDARGGYAGFRGGNAPAPVPPAEMSAEQLQEMYSAPSALRPGTDRVLTMDDVVMKTLGLFALVVGFGAVGWGIAAYDQVLGLGVWIGGMIATLILGLVIAFKKTLSVPLIVGYAVVEGLFVGAVSQFFEQMYRGIVAQAVLATLATFVGMFLAYKVGLIKVTPKFRRIVTMMIFGYAIFAVVNFVFAMVTNTAFGFGGSGWLGIGISLFAVGLASVSLALDFDMVDRAIATGAPQKYSWLLAHGIIVTLVWLYIEFLRLIARMRE
>NZ_CP049935.1|WP_166122072.1|2466398_2466740_-|hypothetical-protein
MTDARPAGAGAGEPAPAPPSVDPVPEAARGELERIRRRWSELPLARAEAAAPAVREVVEALAARTAPDTPVPDLGPAALVDQLAVVVWDACATGAVDGPALTEQLTALRRALP
>NZ_CP049935.1|WP_166122071.1|2465087_2466311_+|acetyl-CoA-C-acetyltransferase
MTEAVIVATARTPIGRAFKGSLREMRPDDLSVQVVRGLLEQLPGVDPTTVDDLYWGCADPSGKAGNNMARVIAVLAGLDGLPAATVNRFCASSTQTMRMAFHAIKAGEGDTFVVGGVESVSTNAAFRGAGESDPEALNPLFADAAARSAAMAAANETWSDPRESGSLPDVYLAMGQTAENVATLRGISRQRQDEWGVTSQNRAEKAIANGFFEREILPVTLGDGTVVSRDDGPRAGVTLEAVQGLQPVFREGGTVTAGNCCPLNDGASGVVVMSDTRARELGLTPLARIVSTGVSGLSPEIMGLGPVEASRQALSRAGLGIGDIDLYEINEAFAAQVLPSADDLGMDLEKLNVNGGAIALGHPFGSTGTRIMTTLLGGLEERDGTFGLETMCVGGGQGMAIVVERLA
>NZ_CP049935.1|WP_166124362.1|2464489_2464882_-|RidA-family-protein
MDTTRSRASSGSPYEGSVGFARAVRVGQHVAVSGTAPIGPGGQVPKDPGEQARRCWEIALGALAELGGTPEDVIRTRHFVTDLDVVDAVSAVHGEIFGDIRPASTMVLVAGLLDARWLVEVEVDAVVPEA
>NZ_CP049935.1|WP_166122069.1|2461477_2462854_-|cystathionine-beta-synthase
MKYAEHIADLVGHTPLVKLNSVTEGIGATVLAKVEYLNPGGSVKDRIALKMVEAAEASGELQPGGVIVEPTSGNTGVGLALVAQRKGYTCIFVCPDKVSEDKRNVLRAYGAEVVVCPTAVAPDHPDSYYSTSDRLVRDTPKAWKPDQYSNPNGPLSHYETTGPEIWDDTDGRITHFVTGAGTGGTISGAGRYLREVSADREGGRVQVVAADPEGSVYSGGTGRPYLVEGVGEDFWPSAYDPDQVDRVEAVSDADSFEMTRRLAREEGLLVGGSCGMAVVAALRVARELPDDAVVVVLLPDSGRGYLSKIFNDDWMASYGFMKAQGERSVGDVLHAKAGDLPALVHTHPNETLRDAIEILREYGVSQMPVVKAEPPVVSGEVAGSVSERELLEALFTGAAHLADPVEKHMGPGLPLVGAGEPVSTARHELEGSDAVLVVEDGKPVGVLTRADLLSFLAD
>NZ_CP049935.1|WP_166122067.1|2460952_2461432_-|DUF1992-domain-containing-protein
MVERPRYESPVERAIREAQERGEFDDLPGAGKPLRVENTDDPMWWVRQLVEREQLDFTGALPPAVALRKEAATFPESLADLRTEESVRAVLEDFNRRVRRDRLRPPESHLPPLLAPTVDVDELVEGWRALRAASQAADVDPPVTSGEARPRRRWWRRRR
>NZ_CP049935.1|WP_166122065.1|2458866_2460894_-|NADPH-dependent-2,4-dienoyl-CoA-reductase
MSDHPHLLAPLDLGHLTLPNRVVMGSMHTGLEDRAKDFPKLAAYLAERARGGAALIVTGGFAPNVEGTLYPGASKLTSRRELARHRLVTEAVHAEGGRIALQLLHAGRYAFTPWCVAPSAVKSPISKFRPRALSDKGVRRQVRAFARAARLAQEAGYDGVEVMGSEGYLLNQFLAPRTNRRTDRWGGTPENRRRFAVEVVRAVREATGPDFLLVYRISVLDLVEDGQTWDEVTALAREVEAAGASILNLGIGWHEARVPTIVTSVPRAAFTGYAARLKEHVALPVVATNRINTPDVAESVLAGGADLVSMARPFLADPEFVRKAAEGRSDEINTCIACNQACLDHTFVKKAATCMVNPRAGREIELVIGRAPVRRKVVVVGGGPAGMAAAVTAAERGHEVELVEARDHLGGQFDIAMRIPGKEEFSETIRYFTRRLEVLGVTVRLGERADVDGLVAAGVDEVVVATGVAPRLPNIPGVEHPMVMTYDQLVRGERTAGRRVAVIGAGGVGVDVCEFLTTDRSPTLDADAWRHEWGVGDPAETRGGLVPPVPEASPREVVLLQRKATSIGRGLGKTTGWVHRASLRAKGVEQVTGVHAYERIDDEGLHVTLGEDGAERRVIACDTVVVCAGQESVRGLAEPLAEHGIRVHVVGGADVAAELDAKRAIRQGTEVAARL
>NZ_CP049935.1|WP_166122063.1|2457640_2458855_+|amidohydrolase
MDAHLLGRLATAYRDLHSHPELSGQEVRTAGVAATWLRENGFDVTEGVGGTGVVGVLRRGEGPCVLLRADMDALPVQEATGLPHASTVDGVMHACGHDVHVTCLVGAAATLAADPGWSGTLVCLFQPAEETASGARAMVADRLAELVPRPDVVLGQHVAPLPAGSLGLRTGPAFAATDSLRVTLWGRGGHGSRPETTVDPVVMAAATALRLQGVVAREVAGTETAVLTVGALNAGTAPNIIADRAELLVNIRSSDEAVRQRVLGAVERIVRAEAQASGAPREPGVERIESAPAVLNDPAATDVVRRALGAVVGAARVVEPGPVTGSEDVGVIAEGLGAPLVFWLLGGADPAAFAGAASTEDVVRVVAGLPSNHSPHFAPVEDPTLAVGVQALVAAARAWLAPTA
>NZ_CP049935.1|WP_166122061.1|2455886_2457497_+|carbohydrate-binding-domain-containing-protein
MKLTKARAAVTAALLAATLAGCGVAGAVTGASVDDSSTTTTATATPGASVEAVLAANQESHAEADDGTYDASSAVTVTLSGSSATASGDGVSVKDSTVTITAPGTYVLTGTLAGQVVVDSSVEGKVQLVLDDAHVTSSTGPAVSVTAADEVVVVLADGSTNTLEDGSGYGDGEGEPNAALYSAADLTIAGTGSLTVTGNSNDGIGSQDGLVILSGTVTVTAVDDAVRGKDYVRVEGGILTATAGGDALKSDNAEEGDRGYVVVLGGTVKLTAGDDGIQAATDAAIGGGTTTITAEGDGIHGDVSATVGGGTTTVTKSSEGLEGKVVTVSGGSIDITSSDDAVNATDGSSSGGGMGGGGNSSQDGVSVTISGGTLVVDAEGDGLDSNGSMSITGGTIVVSGPTASGNGALDTNGGLTITGGTLLAAGSSGMAEAPSTDSEQGWVSATFDSGYAEGTVVQVVQDGKVIASFTASKTFSSVVFSSSAITSGETYEIWVDGTPSGTAVGGLTLGGSTDGGSKLGTVTADVHTGGQGGPGH
>NZ_CP049935.1|WP_166124361.1|2455237_2455876_+|VTC-domain-containing-protein
MLTDLAPAGTRVLEIDGHRTLGYTTRYLDTEDLLTYHLAAHRRRRRFKVRSRRYDLGGESYLEVKTRAQDHTVKTRLEGDHLWHDRMDSAGRQFVTEALVASSIDADVVPDLAPTLDIRYDRTTLHLADDGTRVTVDRALRWERPDGLRLERPDLVVVETKSPGRASSLDRVLWSLGHRPRRMSKYATGLAALDPALPANRWARTLRDHVRP
>NZ_CP049935.1|WP_166122076.1|2468086_2469016_-|hypothetical-protein
MRAWLADLPADDVEELTFGMEADLAERAAEGDVRLGDLLGEPEEYAAELRSAAGLPPRTATVEGASSPGWFGELSAAVRTAGVDAVARWPWLRDLRPVWWVARGLVLGWALAVVLGTALWMLPVLSAAASFALGRALARPPRGTGVGVAVTLANVLAALLLFPSLVSALDEPADGPVDGWNPPGISLDGSQVSDLYVYDAAGNRVEGARILTEDGRGLFVDPGAVNGDDEVPLRPDGSADVATDVFPLVVGDRDPWAGSGTGWTPPLTLSPLPGAPAPTASGAASPSPSPSPSASMASSPVPTATPSVG
>NZ_CP049935.1|WP_166122078.1|2469069_2469402_-|PadR-family-transcriptional-regulator
MDGTQLVKGVLDLAVLAVVAGEDGYGYDIVRRLRDAGLEEVGDASVYGTLRRLYAAGALTSYVVPSDEGPHRKYYGINPEGRHVLETQAKTWGGFVATMDGLLTGAGAAS
>NZ_CP049935.1|WP_166122080.1|2469901_2470594_-|class-I-SAM-dependent-methyltransferase
MAEEMLRHTGATMVPRTVAIDDAVRAHGAAQVVVLGAGLDSRAWRMPELAGATVFEVDHPASRADKQRRLRGLEPVAGRVVPVAVDLAEDPLADALLAAGLDDTRPTTWVWEGVVPYLTRVAAISTLVQLAVLSAPGSRLVVQYQSRSAVMSVMRRVARVAHRVARQPDPLAGEPWRTLLRPDELATWLAPCRYRVLADRSLLELAAGLDLPDGSTGSLRTGRVAVAEKA
>NZ_CP049935.1|WP_166122082.1|2470769_2471858_-|Ppx/GppA-family-phosphatase
MPPRPRRPLARLRARGQPARRRGARDARAVVGPRALLGNSCGRGLVTRRVGAVDCGTNSIRLLVADVGDDGLLTDVDRRTEVVRLGQGIDRTGVIAPEAMQRTLAMSREYAARCRELEVEAVRFVATSASRDARNADEFVAGVREAFGDLDVAPEVVAGEVEARLSFTGATGDLRRLGVPGPYLVVDLGGGSTELVRGTDDVEAGRSVDVGCVRMTERHLAGDPPTDDEVVAARADVALALDSAEEVVDLAGLGTVVGLAGSITTVTAHALGLGRYDRDAIHLAEVSLDAHRASCRALLGMSRAERAALPYMHPGRVDVIGAGALVWHEVLGRVAVRSGAVRVVTSEHDILDGIALSVADGP
>NZ_CP049935.1|WP_166122084.1|2472243_2472921_-|septum-formation-initiator-family-protein
MATSRSTGPASRPPRRGSAARPSAASRATASGTAGKVTKGTTARGTGRAATRPTTPSAARSASAAPRPSTTSTTTAKVVRRAPSGWRGRVGGAASNRVLRRGVVLAAIGVFITVLLASSVAAWVHQRGQIAALREKVASQEADVAGLRAERERWNDPAYVEQQARQRLKFVRPGERSYTVLDPQPASPDTPTIAGPGADEPASTLPWYSTVWQSVRTADAPGAQR
>NZ_CP049935.1|WP_166122086.1|2472947_2474237_-|phosphopyruvate-hydratase
MASIEAVGAREILDSRGNPTVEVEVALDDGTVARAAVPSGASTGAFEAVERRDGDKGRYGGKGVEKAVDAVIDELGPKLLGFEASEQRLVDAEMLAIDGSANKEKVGANAILGVSLAVARAAADSADLPLFRYVGGPNAHVLPVPMMNILNGGSHADSNVDIQEFMIAPIGAESFREALRWGAEVYHELKSVLKEKGLATGLGDEGGFAPNLESNRAALDLILEAIGRAGYTPGEQIALALDVAASEFHDDGSYSFEGGSKTSAEMIDYYADLVASYPLVSIEDPLDESDWDGWKAMTDRLGAQVQIVGDDLFVTNPERLARGIETGTANALLVKVNQIGSLTETLDAVDLAHRNGYRCMMSHRSGETEDVTIADLAVATNCGQIKTGAPARSERVAKYNQLLRIEEELDDAAVYAGAGAFPRFTAGRG
>NZ_CP049935.1|WP_166122088.1|2474279_2475143_-|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein
MLPDLRRILDGGQGVLDTAAAVRAGLSADDLRRAVSAGELRRVRRGLYAAGAVWDAAPPWERYRLTVVGVLAAHPGWVASHHAALVLHGLPMHGIALASVDVAAEVGTAKVRPGVHVHRLARDDRHLRSADPRALPPAVACAQVAARDGVEAGVVPMDAALHEGRCTRSDLRAALGHPSTGHGVAHARAAVDRADHHAESPGESRTRLLLEPLGVEVRTQVDLHDAAGLIGRASPSRPERRSGRRAGFVTPSLLHRARAHPSGSPAEPAEPGRPGCGSVAGRPGHRV
>NZ_CP049935.1|WP_166122090.1|2475270_2476209_-|pseudouridine-5'-phosphate-glycosidase
MTTAAPATPHPMLAVAPEVRDALAEGRPVVALESTIISHGMPYPQNVGMAREVEQIVRDGGAVPATVAILHGRPTVGLTDDELEMFGADTAIRKVSVRDMAHVVATGVHGATTVASTMRIAALAGISVFVTGGLGGVHRGAESSMDVSADLTELSRTPVAVISAGVKSILDIARTLEALETLEVPVVGYGTDDFPSFFSRSSGVAVPMRVDTPEEAARLVAAQLDLGLGAGISIANPVPVEDEMAREDIDGVIAQALADADARGVVGKDITPYLLGRLVELSDGRSLETNLALVRNNARVGTAIAVALAALR
>NZ_CP049935.1|WP_166122092.1|2477566_2478511_-|MazG-family-protein
MTAGRLGLVVTSPRVAPGLLSHAAWSAVAGADRRLARSADEPLVEALTDAGVEVECVGDVAPAALARQLVDLAGSVSVVWLGSSDADPGLSDAVAAEVSRLEVPPDVELVVGSWDVQGGRLLDVVAAMDRLRSPGGCPWDAEQTHASLAPYLVEEAHEVLEAIDTGDPRLLAEELGDVLLQVVFHARVAEDAGEDGFDVDTVAGLLVDKLVRRHPHVFADGDASTPEEVEQEWERIKGEEKAGAYAEDLLHGVPGSLPPELAATKVLARVRRRGLGVEATALAELEASRVALAAAEERVRTALRAVADGATPTA
>NZ_CP049935.1|WP_166122094.1|2478507_2479005_-|hypothetical-protein
MTLPVRRVAASLALGAALVTAGCGSTEAGRAATVDGRVITEDQVHTAQSEINKAFPAANLTTADVVYRLIEAPYVIDYVAKKGAPQSASVARSNFPATAEPSAEAIELLRGQYARQVLEQAGETLPADTFAKVKVVVNPRYGTFDPSKNALTATRPDWLAGAGTK

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Crispr_ID: NZ_CP049935_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049935_7

2746040-2746130

Orphan

Consensus_repeat	Method
GTGGTGCGCTGTCACCTCGACCCGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049935_7

>merge|NZ_CP049935|7|2746040-2746130|CRISPRCasFinder
GTGGTGCGCTGTCACCTCGACCCGGACGTGGACCCGGATGGGTCGAGGTGATACCGCACCTGCTCGTGGTGCGCTGTCACCTCGACCCGGA

>NZ_CP049935|7|6|2746040-2746130|CRISPRCasFinder
GTGGTGCGCTGTCACCTCGACCCGGA	CGTGGACCCGGATGGGTCGAGGTGATACCGCACCTGCTC
GTGGTGCGCTGTCACCTCGACCCGGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049935.1\|WP_166122483.1\|2737830_2739240_-\|bifunctional-PIG-L-family-deacetylase/class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|225031
NZ_CP049935.1\|WP_166122495.1\|2742968_2743793_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274373
NZ_CP049935.1\|WP_166122509.1\|2754830_2755688_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP049935.1\|WP_166122485.1\|2739236_2740253_-\|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NZ_CP049935.1\|WP_166122507.1\|2753792_2754788_+\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176191
NZ_CP049935.1\|WP_166122503.1\|2750604_2751408_-\|copper-resistance-protein-CopC	unknown	unknown	gnl\|CDD\|377255
NZ_CP049935.1\|WP_166117785.1\|2744625_2745408_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187632
NZ_CP049935.1\|WP_166122493.1\|2742693_2742972_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166122501.1\|2749058_2750531_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375554
NZ_CP049935.1\|WP_166122481.1\|2737111_2737834_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133035
NZ_CP049935.1\|WP_166122511.1\|2755798_2756446_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP049935.1\|WP_166122487.1\|2740436_2740643_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166124385.1\|2751412_2752756_-\|PepSY-domain-containing-protein	unknown	unknown	gnl\|CDD\|225723
NZ_CP049935.1\|WP_166122497.1\|2743916_2744432_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166122513.1\|2756878_2757628_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340879
NZ_CP049935.1\|WP_166122489.1\|2740642_2741209_+\|GAF-and-ANTAR-domain-containing-protein	unknown	unknown	gnl\|CDD\|198080
NZ_CP049935.1\|WP_166124386.1\|2756429_2756834_-\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NZ_CP049935.1\|WP_166122499.1\|2747771_2748968_-\|glutathione-dependent-formaldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|176243
NZ_CP049935.1\|WP_166122491.1\|2741340_2742540_-\|ANTAR-domain-containing-protein	unknown	unknown	gnl\|CDD\|377145
NZ_CP049935.1\|WP_166122505.1\|2753016_2753571_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP049935.1\|WP_166122483.1\|2737830_2739240_-\|bifunctional-PIG-L-family-deacetylase/class-I-SAM-dependent-methyltransferase	gnl\|CDD\|225031	COG2120, COG2120, Uncharacterized proteins, LmbE homologs [Function unknown].	2.17533e-19
NZ_CP049935.1\|WP_166122495.1\|2742968_2743793_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274373	TIGR02980, SigBFG, RNA polymerase sigma-70 factor, sigma-B/F/G subfamily. This group of similar sigma-70 factors includes clades found in Bacilli (including the sporulation factors SigF:TIGR02885 and SigG:TIGR02850 as well as SigB:TIGR02941), and the high GC gram positive bacteria (Actinobacteria) where a variable number of them are found depending on the lineage.	3.77618e-68
NZ_CP049935.1\|WP_166122509.1\|2754830_2755688_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.37824e-30
NZ_CP049935.1\|WP_166122485.1\|2739236_2740253_-\|acyl-CoA/acyl-ACP-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	4.31094e-08
NZ_CP049935.1\|WP_166122507.1\|2753792_2754788_+\|NADP-dependent-oxidoreductase	gnl\|CDD\|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	4.2047e-111
NZ_CP049935.1\|WP_166122503.1\|2750604_2751408_-\|copper-resistance-protein-CopC	gnl\|CDD\|377255	pfam04234, CopC, CopC domain. CopC is a bacterial blue copper protein that binds 1 atom of copper per protein molecule. Along with CopA, CopC mediates copper resistance by sequestration of copper in the periplasm.	7.61775e-23
NZ_CP049935.1\|WP_166122501.1\|2749058_2750531_-\|hypothetical-protein	gnl\|CDD\|375554	pfam18105, PGM1_C, PGM1 C-terminal domain. This is the C-terminal domain found in PGM1 present in Streptomyces cirratus. PGM1 is a gene product that links precursor peptides together to form the antibiotic Pheganomycin.	3.6176e-06
NZ_CP049935.1\|WP_166124385.1\|2751412_2752756_-\|PepSY-domain-containing-protein	gnl\|CDD\|225723	COG3182, PiuB, Uncharacterized iron-regulated membrane protein [Function unknown].	7.58832e-90
NZ_CP049935.1\|WP_166117785.1\|2744625_2745408_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187632	cd05374, 17beta-HSD-like_SDR_c, 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs. 17beta-hydroxysteroid dehydrogenases are a group of isozymes that catalyze activation and inactivation of estrogen and androgens. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	5.06122e-47
NZ_CP049935.1\|WP_166122481.1\|2737111_2737834_-\|glycosyltransferase	gnl\|CDD\|133035	cd04192, GT_2_like_e, Subfamily of Glycosyltransferase Family GT2 of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	1.0888e-13
NZ_CP049935.1\|WP_166122511.1\|2755798_2756446_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	4.72008e-09
NZ_CP049935.1\|WP_166122513.1\|2756878_2757628_-\|MFS-transporter	gnl\|CDD\|340879	cd17321, MFS_MMR_MDR_like, Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.62422e-19
NZ_CP049935.1\|WP_166122489.1\|2740642_2741209_+\|GAF-and-ANTAR-domain-containing-protein	gnl\|CDD\|198080	smart01012, ANTAR, ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.	8.14e-11
NZ_CP049935.1\|WP_166124386.1\|2756429_2756834_-\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	9.41828e-36
NZ_CP049935.1\|WP_166122499.1\|2747771_2748968_-\|glutathione-dependent-formaldehyde-dehydrogenase	gnl\|CDD\|176243	cd08283, FDH_like_1, Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1. Members identified as glutathione-dependent formaldehyde dehydrogenase(FDH), a member of the zinc-dependent/medium chain alcohol dehydrogenase family. FDH converts formaldehyde and NAD(P) to formate and NAD(P)H. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. MDH family uses NAD(H) as a cofactor in the interconversion of alcohols and aldehydes, or ketones. Like many zinc-dependent alcohol dehydrogenases (ADH) of the medium chain alcohol dehydrogenase/reductase family (MDR), these FDHs form dimers, with 4 zinc ions per dimer. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.	0
NZ_CP049935.1\|WP_166122491.1\|2741340_2742540_-\|ANTAR-domain-containing-protein	gnl\|CDD\|377145	pfam03861, ANTAR, ANTAR domain. ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.	1.43644e-14

>NZ_CP049935.1|WP_166117785.1|2744625_2745408_+|SDR-family-NAD(P)-dependent-oxidoreductase
MRSPTPRTTGAVVTGASSGIGRATALRLARDGVAVVATGRDLASLEVVVDACRALGGSARAEVLDVRDDAGVRRVLDEAAAEHGRDLAVVHAAAVVAYGHFEEVPAEVMSDVVDTDVLGTVNVARAALRAFRRTGGGHLVVVGSLLGEIATPYMSPYVLSKWAVHGLVRTLQIETRDRVGTEVSLVSPGGIDTPVYRQAATVLGRHGAPPRPSAPTRPWPLAWPRCCGAPDGRRTSGPPTRSRSPASASSPASSTSSSPP
>NZ_CP049935.1|WP_166122497.1|2743916_2744432_-|hypothetical-protein
MTAQDALVRALVDQHVRIRELTRGLVRAGPDARPDALDRLVRLVAVHCAAERVALAPPGEPPPENSPVDRDLVTALEGLDDVGAERPSSTVHVGLVAAALVRHAAAGERDTVPRFVATHDQFDIRWAATALEAVDALVADDGPTAAVPVEAGFRHQLRAAQDAVTEALRHG
>NZ_CP049935.1|WP_166122495.1|2742968_2743793_-|sigma-70-family-RNA-polymerase-sigma-factor
MPGRPTTPDRTDTPDPGPASGAPRPPDDVTELLLLELHHTTDPDDRQRLRSEVVASFLALADGLAHRYAGRGVDREDLEQVARTALVVAVERYRPDSGTRAGFVAFAVPTITGELKRHFRDCGWMVRPPRRLQELRAEVSVAEEGLRHRHGREVTVSEVAELVGCSPGDVRSARSTSSGFRPTSLDAPVPMGGTEADRLADDEDAFGRLEVGIDLREAVAALGARDRAVVRLRFVEELTQSQIGTALGVSQMQVSRILARILGDLRGTLAADAA
>NZ_CP049935.1|WP_166122493.1|2742693_2742972_-|hypothetical-protein
MNRLSDVGAASCRTCGLLVAMLRAELSYTPGVAPAVHWSEAGRQCRCATTRLPGAASLPSAVRVRLRDLGEAAASARPWEQLAARAPLHLLV
>NZ_CP049935.1|WP_166122491.1|2741340_2742540_-|ANTAR-domain-containing-protein
MRDRRPRHRRAGLPLPGADETSALARATDWSSTPLGDPSTWGPELSAAIRTVVPAGIPMLLWWGPELVQVYNDAYRPICGAKHPRSMGQPAAECWPEAWAELGPRVARVVATGESDHEEALLLFLERHGYVEETYWRYSFSAVRSATGEVLGVFVATTEVTATRIDGYRLTAVRELAVLSSADLVSAEGLVQRVEPVLAGDRRAVPFAAVHLVDAAGDLVRAGSHGLLDGGSALPQHVAGDADHPLARTASARTSRTVHTVDGELTAEPSPLGPLAPTDLVHVPLGRPDGRVEGVLSVGLDPYRPFDEAYDTFVTLLARQLTALLTDVRAAAEERARTGNLEVALRTNRTIGTAVGVLMASRRLSADEAFDRLRSASSTSNRKLREVAEDVVLTGQLPG
>NZ_CP049935.1|WP_166122489.1|2740642_2741209_+|GAF-and-ANTAR-domain-containing-protein
MRSETLRTLAASHDEALEADEVQYDIGSGPCVDAVVRDHVFVTGRVQDDPRWPEYGRRVHEALGVSSVLAQRLTLPDGNESVAALNIYSRTPDAFGALAMREGLLLATQCSLLVAAHLAHDRAENLTRALTSNRDIGVAIGILMSRHRITRDEALGMLRVVSQDANRRLSDIAADVTDTGDLPDGPRG
>NZ_CP049935.1|WP_166122487.1|2740436_2740643_+|hypothetical-protein
MVEQQHHVPQQPRAALTPSEDSTVLGVVADLLTAARRAPEGLSTRRLLGDLVGRGAHVVPGPTGAASR
>NZ_CP049935.1|WP_166122485.1|2739236_2740253_-|acyl-CoA/acyl-ACP-dehydrogenase
MGTVWRADEWAEDVGVVDGTSPHRALDAARALAGVARALPDDPWTYLATLASLGATDLTAARALEPHLDAVAVLAQAGDPDLSALGVDDDSTFGVYAARAPGTGLEARPGPDGPDLVSGTKAWCSLAGLVSHAVVTTTTGEDERLHVVPLRHPGVTHAASTWVSRGLAAVTTGSLQLDDVPGIPLGGPGWYLGRPGFAWGGIGVAAVWFGGAAALAGALLAAAGRRPPDQVARLHLGTVDRVLHASLLSLRHAADEIRGGRADGPAGSLLAARTRAVVADAAEVVLTAVGHGLGPAPLTHDEPHARRVADLTVYLRQHHAERDLVALGDLVLGARGSG
>NZ_CP049935.1|WP_166122483.1|2737830_2739240_-|bifunctional-PIG-L-family-deacetylase/class-I-SAM-dependent-methyltransferase
MSTAGGPAFHHDDPGTPEPTWLTDARWTGRPVLDLDALAARFDRLVVAAAHPDDETLAVGALAAAAHRRGADVRVVVASAGEASHPEATTWTPLELARVRRAEVAEAVGHLAPGAPVEHLDLPDGRLAEHEARLADLLAERCGPDTLLVAPWTADGHPDHDALGRAAVVAAARTGATPAHYPLWLWHWGGPDDLDWSRVHVVEPTLDDLARKERALAAHRSQTEPLGPATGDGPVVTGPVLARARRVVETLLAEPGTLPVLGGRDPDDPDRTDVDRARPFDAMFDGSADPWGFDGSFYEARKRAMTAALLGRERYRRVLEIGCATGVLTRDLAERADDLVAMDVSPRALEQARHDAPAHVRWVLGAAPDGVPDERFDLVVLSEVGYFLTPTDWLETLRVVRDRLSDGGEVVLVHWRHPTEGIPLDGPTVHAQATTALADLGHRAGHADADVLADVWGGPASVAADEGRR
>NZ_CP049935.1|WP_166122481.1|2737111_2737834_-|glycosyltransferase
MRVAHVVVAVPARDEEELLGPCLDSVVAAVARLRSVRPDVGATVVVALDRCVDGSARAADRPGVESVAVDLGAVGPARRAAVEVGLDRALAAGATTAGTWLAGTDADCVVPEGWLLRQLALADDGADLVVGTVVPDDLVDPRVLRAWRARHALHEGHRHVHGANLGVRADAYLAVGGFPPLPVHEDVALVEAVRATGRRWVATDRARVRTSARTTSRVDGGFASYLAALADPDPTRVAVP
>NZ_CP049935.1|WP_166122499.1|2747771_2748968_-|glutathione-dependent-formaldehyde-dehydrogenase
MKAVVWHGTKDVRVEEVPDPRIEQATDAVIRVTSTNICGSDLHLYEPLGAFMKPGDVLGHESMGIVEEVGSEVGDLSVGDRVVIPFQVCCGHCWMCEHGLQSQCETTQVREQGTGATLFGYSELYGSLPGGQAQYLRVPQAQYTHVKVPDGPADDRFVYLSDVLPTAWQAVAYADPEPGGTLLVLGLGPIGDMACRIALQRGVSRVIGVDRVDARLARARERGVETIDLREVDEVGDAVRQLTSGRGADAVVDAVGMEAHGSPVAKAGHKLVGMLPDAVAKPLMTTVGIDRLAAFYSAIDAVRRGGTISLSGVYGGMTDPMPMMTLFDKQVQIRMGQANVKRWVPDILPLLTDDDPLGVDGFATHHLPIEQAPEAYRTFQAKEDGMVKVVLSPHASTA
>NZ_CP049935.1|WP_166122501.1|2749058_2750531_-|hypothetical-protein
MRADERLPAGLGPALEATARGSEQGHVVVALPSHSMPQRLLDHHASHLPALEHRALLEGLRLAHTPGARVVVVTCAEPGPGVLDYYARLARPDAPDEVRDRLSCLVVDDAGARGVSAKLLEHPRLLERLRAEIGDRPAVIEPWNVTPDESAVALALGVPVNGGPPELWSAGFKSASRRLLRDAGVPIPRGVEDVHDAGEVATAVLRLRDSGTVDRIVVKLDNSGAGEGNWIMPTRDDVGRELSWAELADHVRDHVPAWFLADLAAGGVVEELVTAEGLTSPSAQVEILPGGEVVVRATHDQVLGGEGGQVFTGSRFPADPSYAGDLAAHAAALAGRLAALGAVGPLSVDFVAWADDGRPALAAVDVNLRKGGTSHSLDVLKHLVPGSYDAPAGRWVADRDGGARCYRSGDTVSVAAGAVTDAAGAVAAAEAAGLAFDHARGTGVVLHMFPSLELEGTVGVTAVGRTAEEAERLYAAVPAALGGAGVDPAP
>NZ_CP049935.1|WP_166122503.1|2750604_2751408_-|copper-resistance-protein-CopC
MKTIAHPSGPFPTTHHVPDTTGAGARPTQEPAMYRTGWTRQHRPRSTAPALTALTLTAITALLVLVAGPAAAAGRTAQAAALPTHSRLTATSPKDGATVEPPAKVVLTFNEDIDPQFVKVEVTGPDGGATRGGPQVDRAVVTQKLAPDLAPGTYVVLYRVVSADGHPVSGRTTFRTVAPTPTSTPTATTTSPAATTSPAASATSSASGPATGGPTSTPSPRTLAAGESDGDPTRVVVSGALLVLLVAAGALIARRRRRSQPPQGPAR
>NZ_CP049935.1|WP_166124385.1|2751412_2752756_-|PepSY-domain-containing-protein
MFRAFWRWHFYASIVVIPTVLVLAVTGLVYLFRFQIEPMLHHDLLRVSAPAGATPVTYDEQLTAVQQARPGDTVVSLTEPAAPDQSTRVTVSTPDDATRDVFVDPYTGRVLGALDPDSTISGTAVRIHANLMAGPVGDFVLELGACWAIVMALTGYYLFFRGRRARRRLRRKDPAAARLRSGHAWTGLFIGAGLLLLVVSGLPWTGIWGAQTQKLATAGGTSFWSDDHGALSSPTSTLDESLPHSHGVVPWAQEKSGVPRSTGDPERSVATVDTAVLVGGREGLAHPMTVVLPGDDTGVFSTIGYAFNDPSAERTVHVDRYGGTVVSQYGYDDYSALAKTVSHGIALHEGRHFGTLNMVLTTAFCLAVIASCITGPLMWWRRRPKRSGSIGAPRGRMPVVATPALGVALVLLCLALPVFGASVVVALVAEKVLRRSARARHLFAIAR
>NZ_CP049935.1|WP_166122505.1|2753016_2753571_-|hypothetical-protein
MLRATVATLVVIGLGATAHEMAGGGSLQVVPALILAVLVGPLVWLVVRGRTSLPRMLLATGAGQGVTHLVLAGMAPSTGGAAPRLHVHEAMAPMFSTTGAPGPSVSAHGSMLVAHVVATLVASVLLTRGADVVRSLARRLLLPVSGSVPVPHPGPLPVAPVEVRIPDGRRVGPVGGRAPPLQLV
>NZ_CP049935.1|WP_166122507.1|2753792_2754788_+|NADP-dependent-oxidoreductase
MQAFVIDAYKRPVHPADVPDPTVGDRDVLVEVGAAGLNQLDEKIRLGEFRQLLPYRTPLTLGHDVAGTVVRVGPAVHGFAPGDVVFARPRDHRIGTFAERIAVHEDDVAPAPRTATMVEAASLPLVALTAWQALVEVADVRPGQKVLVHAGAGGVGTVAIQLARHLGADVATTASAQDADFLRELGADVVVDHRTQDFAAELSGYDVVLDSLGGDNLVRSLTVLRRGGIAIGIAGPPTPRFAKEAGLNPLLRVVMTALSRRVRSRAKALGVGYRFLFMRADGRQLREVAALVDSGAIRPVVGRTYPFEETPTALAELGKARTRGKTVVTRA
>NZ_CP049935.1|WP_166122509.1|2754830_2755688_+|alpha/beta-hydrolase
MPSRPEPVITSYADAPTRTLRAAGVTFAYRELGPSGAVPVVFFHHLSANLDNWDPRIVDAVAATRRVITFDQRGVGASSGKVPDTIEAAAEDAYAFVTALGLTEIDVFAFSMGGMVAQDLAVAHPGLIRRWVLTGTGPRGGKDMDKVGRTTYLDVLRATLTRRDPKEILFFEQDSIGRKAATEFVARLGERTRDRDTAVTLGAFRTQLQAIARYGRSAPSDLSPLTIPTLIANGDHDRMVPSVLSEDLHRRIPGSELVIYPNSGHGGIFQYWQDFAPRAAAFLSA
>NZ_CP049935.1|WP_166122511.1|2755798_2756446_+|TetR/AcrR-family-transcriptional-regulator
MTPPPPGRRERNKQEKLERIVAAASSLFAEHGVDDVTTQQIAEAADIGTGTLFLYARTKGELLLMVQNTHYEEALARGRAEAEHAQGAVEAVVALLAPVVECNRAHVGNGRVYLREMLFGDPDVPGHAAALAVVAETDRATVELIRRWTDTDEADAARQAGVIAAAMYVTMASAPRRPSSTTSSTSSVRPSAPSCAAERPPFHRRSTRVRLRASG
>NZ_CP049935.1|WP_166124386.1|2756429_2756834_-|PaaI-family-thioesterase
MQRMAAGLLPPPSIATLLGMDLETVEEGTAAFVLTPDERMLNPLGSVHGGIAATLLDSCMGCAVHTTLPPGGDYTTAQLTVHYLRPMRPGTGQVRAVGTVLHRGRTQSTAEGRLLDADGRLLAHASTTCLIRMP
>NZ_CP049935.1|WP_166122513.1|2756878_2757628_-|MFS-transporter
MGWASATTPAVLVGGLLVLGAFVRRTLSVPHPALDLTIFATPSVRWANIATAAFTIGFTAMFFALVQFTLAVWQYGIVRAGMAMMPGPVVVMALAPVFGRVAARHGQRALLVPGGLVYAAGGLLLLTGLGDRPAYLTELLPASLLSGLGVALVLPQLTSAAVQGLPRDDFGAGAAVNQAIRQLGATFGVALTVAILGTVTPTITAGAFRGVWVMLVVCGVLTSAAAVAVPRRRPALDTVAAPAAVGAQP

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Crispr_ID: NZ_CP049935_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049935_8

2779349-2779424

Orphan

Consensus_repeat	Method
TCCTGGTGGCGGAACCGGGGCTCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049935_8

>merge|NZ_CP049935|8|2779349-2779424|CRISPRCasFinder
TCCTGGTGGCGGAACCGGGGCTCCCACCCCCACCACCCCGCCAGGAAGGCTTCCTGGTGGCGGAACCGGGGCCCCG

>NZ_CP049935|8|7|2779349-2779424|CRISPRCasFinder
TCCTGGTGGCGGAACCGGGGCTCCC	ACCCCCACCACCCCGCCAGGAAGGCT
TCCTGGTGGCGGAACCGGGGCCCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049935.1\|WP_166122574.1\|2786421_2787723_-\|FliI/YscN-family-ATPase	unknown	unknown	gnl\|CDD\|274607
NZ_CP049935.1\|WP_166122570.1\|2784965_2785991_-\|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl\|CDD\|381594
NZ_CP049935.1\|WP_166122542.1\|2771763_2772054_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166122546.1\|2774772_2775420_-\|EscU/YscU/HrcU-family-type-III-secretion-system-export-apparatus-switch-protein	unknown	unknown	gnl\|CDD\|376521
NZ_CP049935.1\|WP_166124390.1\|2781573_2781843_-\|flagellar-FlbD-family-protein	unknown	unknown	gnl\|CDD\|377645
NZ_CP049935.1\|WP_166122550.1\|2776206_2776476_-\|flagellar-biosynthesis-protein-FliQ	unknown	unknown	gnl\|CDD\|235567
NZ_CP049935.1\|WP_166117786.1\|2774311_2774827_-\|EscU/YscU/HrcU-family-type-III-secretion-system-export-apparatus-switch-protein	unknown	unknown	gnl\|CDD\|376521
NZ_CP049935.1\|WP_166122548.1\|2775427_2776207_-\|flagellar-biosynthetic-protein-FliR	unknown	unknown	gnl\|CDD\|376520
NZ_CP049935.1\|WP_166124389.1\|2779903_2780158_-\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|143586
NZ_CP049935.1\|WP_166122560.1\|2779445_2779907_-\|flagellar-basal-body-protein-FliL	unknown	unknown	gnl\|CDD\|235909
NZ_CP049935.1\|WP_166122572.1\|2785987_2786425_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237171
NZ_CP049935.1\|WP_166122562.1\|2780804_2781572_-\|motility-protein-A	unknown	unknown	gnl\|CDD\|181238
NZ_CP049935.1\|WP_166122552.1\|2776486_2777296_-\|flagellar-type-III-secretion-system-pore-protein-FliP	unknown	unknown	gnl\|CDD\|235566
NZ_CP049935.1\|WP_166122558.1\|2778362_2779238_-\|flagellar-motor-switch-protein-FliM	unknown	unknown	gnl\|CDD\|224781
NZ_CP049935.1\|WP_166122566.1\|2783357_2783789_-\|flagellar-hook-capping-protein	unknown	unknown	gnl\|CDD\|236594
NZ_CP049935.1\|WP_166122568.1\|2783793_2784966_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350657
NZ_CP049935.1\|WP_166122564.1\|2782067_2783294_-\|flagellar-hook-protein-FlgE	unknown	unknown	gnl\|CDD\|235557
NZ_CP049935.1\|WP_166122554.1\|2777282_2777900_-\|flagellar-biosynthetic-protein-FliO	unknown	unknown	gnl\|CDD\|377320
NZ_CP049935.1\|WP_166122556.1\|2777899_2778340_-\|flagellar-motor-switch-protein-FliN	unknown	unknown	gnl\|CDD\|236154
NZ_CP049935.1\|WP_166122544.1\|2772055_2774140_-\|flagellar-biosynthesis-protein-FlhA	unknown	unknown	gnl\|CDD\|376386

Protein	Function_ID	Function_description	E-value
NZ_CP049935.1\|WP_166122574.1\|2786421_2787723_-\|FliI/YscN-family-ATPase	gnl\|CDD\|274607	TIGR03496, FliI_clade1, flagellar protein export ATPase FliI. Members of this protein family are the FliI protein of bacterial flagellum systems. This protein acts to drive protein export for flagellar biosynthesis. The most closely related family is the YscN family of bacterial type III secretion systems. This model represents one (of three) segment of the FliI family tree. These have been modeled separately in order to exclude the type III secretion ATPases more effectively. [Cellular processes, Chemotaxis and motility].	0
NZ_CP049935.1\|WP_166122570.1\|2784965_2785991_-\|transglycosylase-SLT-domain-containing-protein	gnl\|CDD\|381594	cd00254, LT-like, lytic transglycosylase(LT)-like domain. Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.	3.57257e-37
NZ_CP049935.1\|WP_166122546.1\|2774772_2775420_-\|EscU/YscU/HrcU-family-type-III-secretion-system-export-apparatus-switch-protein	gnl\|CDD\|376521	pfam01312, Bac_export_2, FlhB HrpN YscU SpaS Family. This family includes the following members: FlhB, HrpN, YscU, SpaS, HrcU SsaU and YopU. All of these proteins export peptides using the type III secretion system. The peptides exported are quite diverse.	3.68378e-45
NZ_CP049935.1\|WP_166124390.1\|2781573_2781843_-\|flagellar-FlbD-family-protein	gnl\|CDD\|377645	pfam06289, FlbD, Flagellar protein (FlbD). This family consists of several bacterial FlbD flagellar proteins. The exact function of this family is unknown.	2.05317e-26
NZ_CP049935.1\|WP_166122550.1\|2776206_2776476_-\|flagellar-biosynthesis-protein-FliQ	gnl\|CDD\|235567	PRK05700, fliQ, flagellar type III secretion system protein FliQ.	4.51202e-22
NZ_CP049935.1\|WP_166117786.1\|2774311_2774827_-\|EscU/YscU/HrcU-family-type-III-secretion-system-export-apparatus-switch-protein	gnl\|CDD\|376521	pfam01312, Bac_export_2, FlhB HrpN YscU SpaS Family. This family includes the following members: FlhB, HrpN, YscU, SpaS, HrcU SsaU and YopU. All of these proteins export peptides using the type III secretion system. The peptides exported are quite diverse.	1.17e-66
NZ_CP049935.1\|WP_166122548.1\|2775427_2776207_-\|flagellar-biosynthetic-protein-FliR	gnl\|CDD\|376520	pfam01311, Bac_export_1, Bacterial export proteins, family 1. This family includes the following members; FliR, MopE, SsaT, YopT, Hrp, HrcT and SpaR All of these members export proteins, that do not possess signal peptides, through the membrane. Although the proteins that these exporters move may be different, the exporters are thought to function in similar ways.	1.62526e-45
NZ_CP049935.1\|WP_166124389.1\|2779903_2780158_-\|OmpA-family-protein	gnl\|CDD\|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	5.80987e-17
NZ_CP049935.1\|WP_166122560.1\|2779445_2779907_-\|flagellar-basal-body-protein-FliL	gnl\|CDD\|235909	PRK07021, fliL, flagellar basal body-associated protein FliL; Reviewed.	3.98943e-15
NZ_CP049935.1\|WP_166122572.1\|2785987_2786425_-\|hypothetical-protein	gnl\|CDD\|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	0.00225841
NZ_CP049935.1\|WP_166122562.1\|2780804_2781572_-\|motility-protein-A	gnl\|CDD\|181238	PRK08124, PRK08124, flagellar motor protein MotA; Validated.	5.94489e-71
NZ_CP049935.1\|WP_166122552.1\|2776486_2777296_-\|flagellar-type-III-secretion-system-pore-protein-FliP	gnl\|CDD\|235566	PRK05699, fliP, flagellar biosynthesis protein FliP; Reviewed.	3.69876e-112
NZ_CP049935.1\|WP_166122558.1\|2778362_2779238_-\|flagellar-motor-switch-protein-FliM	gnl\|CDD\|224781	COG1868, FliM, Flagellar motor switch protein [Cell motility and secretion].	4.34029e-42
NZ_CP049935.1\|WP_166122566.1\|2783357_2783789_-\|flagellar-hook-capping-protein	gnl\|CDD\|236594	PRK09618, flgD, flagellar hook assembly protein FlgD.	1.17952e-20
NZ_CP049935.1\|WP_166122568.1\|2783793_2784966_-\|hypothetical-protein	gnl\|CDD\|350657	cd17470, T3SS_Flik_C, C-terminal domain of flagellar hook-length control protein FliK and similar domains. The flagellar hook-length control protein FliK is a soluble cytoplasmic protein that is secreted during flagellar formation. It controls hook elongation by two successive events: by determining hook length and by stopping the supply of hook protein. It contains an N-terminal domain that determines hook length and a C-terminal domain that is responsible for switching secretion from the hook protein to that of the filament protein, by interacting with FlhB, the switchable secretion gate.	5.1237e-20
NZ_CP049935.1\|WP_166122564.1\|2782067_2783294_-\|flagellar-hook-protein-FlgE	gnl\|CDD\|235557	PRK05682, flgE, flagellar hook protein FlgE; Validated.	1.27851e-120
NZ_CP049935.1\|WP_166122554.1\|2777282_2777900_-\|flagellar-biosynthetic-protein-FliO	gnl\|CDD\|377320	pfam04347, FliO, Flagellar biosynthesis protein, FliO. FliO is an essential component of the flagellum-specific protein export apparatus. It is an integral membrane protein. Its precise molecular function is unknown.	5.17937e-11
NZ_CP049935.1\|WP_166122556.1\|2777899_2778340_-\|flagellar-motor-switch-protein-FliN	gnl\|CDD\|236154	PRK08119, PRK08119, flagellar motor switch protein; Validated.	4.22324e-33
NZ_CP049935.1\|WP_166122544.1\|2772055_2774140_-\|flagellar-biosynthesis-protein-FlhA	gnl\|CDD\|376386	pfam00771, FHIPEP, FHIPEP family.	0

>NZ_CP049935.1|WP_166122558.1|2778362_2779238_-|flagellar-motor-switch-protein-FliM
MSVEPAAYDFRSPDRLSRQREQALQVVAETYARRVSTVLSTGLRTIVTARVAGLGQRTYGEFLDALARPSVLGALSVEGLPGGGHLQLGLGDTMGFLDRMLGGTGTGAQPERPLTEIEAALAEQLVGQLAAELPFAFSVVGDLPVAPTGLETTTRFHQVARVTDPVVTIEVEVTVFERPVPLTVCLTLSTLTPLLTTLDRVAEDDDAAAGERTAQTRRVVTDRLSQVEVDVQVAFREVTLTSGEVFALTVGDLVPLRHRVHDPLVVSTGGVRVARATPGSHGRRLAVQIVP
>NZ_CP049935.1|WP_166122556.1|2777899_2778340_-|flagellar-motor-switch-protein-FliN
MTFPDAPQDPFASGTDFAAAAPVAPTVPVTSAVPVTSAVPASPVPAAPVPAAAVPPAAVDPRRLHLLREVELGISVELGRSRMTVREVLALAPGAVVELDRPAGSPVDVLVNGTLMARGEVVVVDDEYAVRITEVVSSDPAVGLGA
>NZ_CP049935.1|WP_166122554.1|2777282_2777900_-|flagellar-biosynthetic-protein-FliO
MDGSTVLAVLRLLVSLGVVLTLLVMLARWARKRGVGGTVGGRTGVEVELLSRRALSRGSALHVVRVGEQVLVLGVTDQQVSVLRELDPVPAVAAVPAVAAVPGDDDEDGPGPAPERDFASVLAARSAAEPHAALALVPTTRAERRAIERRHPSRLRLPAVSHTGTHAGAHAGTAQHGGSPTTPVPTGWPWNAATLVVGAIKGGRA
>NZ_CP049935.1|WP_166122552.1|2776486_2777296_-|flagellar-type-III-secretion-system-pore-protein-FliP
MVVPSPLAPVRRLRHLALLAGVLLLTVGPGAAVASAAPSPTPSPSASTPGTVSVNIDPAAAAPSQTVTIIVLLTVLSLAPALLVLTTAFTKVIVVLSLTRNALGTQTIPPNQVLVGLALFLSMFIMAPVLSQMNDQGVQPYLKGEISQSVAVERTVEPLRDFMGKQTRPAELATMVKLSGEEKPASIDDVPLTTLVPAFVLSELKSAFIIGFVVFVPFLVIDVVVSSVLMSMGMMMLPPALISLPFKLLLFVMVDGWGLIVTALVQSYR
>NZ_CP049935.1|WP_166122550.1|2776206_2776476_-|flagellar-biosynthesis-protein-FliQ
MTDADIVHIGVQAMIVSAKLALPVLLTALAIGFVISLFQAVTQVQEVTLSFVPKLLGVAVVLVVAGHWMLAEIVAFTRSMFAMLPQLLA
>NZ_CP049935.1|WP_166122548.1|2775427_2776207_-|flagellar-biosynthetic-protein-FliR
MTISLAADSFVTMLLATVRLSAFFLLAPPFSSKAVPVRVKAGLAVALALAVLPSLRGQATPALELLPLAGAALYQAAVGAVMGFVVLAAFAVVQAAGELLDLASGFTLASLYDPLSNVSASMFGRIQQLLAITMLFAAGGHLFLVRGLISTFSVVPLHPMSLGDLARLVTHDVGTFLGGALQVAAPVLVVLFLSEVALGLISRAVPTLNIFAISFPVKIVLAISFAGIAFAMLPGVVSGLLDQAGRDMTSVARMMGAAG
>NZ_CP049935.1|WP_166122546.1|2774772_2775420_-|EscU/YscU/HrcU-family-type-III-secretion-system-export-apparatus-switch-protein
MSDKASKTEKPTQQKLKKARRDGQVPRTAELSAWVAVLLASLLLPRLAAGLGELMADLLQGVREVVIDPRPEQGIAVMRQAGVDALWLMAPFFGVMVAAALVSNGAQGGLRVFPGKFKPNFKVLNPGKGLKQLVSAHSAWTFAKTMLKFVVFGWIGYTQLRDVAVLMTSGGSWSLGPRRQRPSVPPSTSSRSSPVSGWCSPPPTTRPSAGGSAPR
>NZ_CP049935.1|WP_166117786.1|2774311_2774827_-|EscU/YscU/HrcU-family-type-III-secretion-system-export-apparatus-switch-protein
MLAAADYAAERRRIGTSLKMSMDEVKREHKQTDGDPFVKGMIRGKQRQMSRNRMLADLSSADVVLVNPTHVAVALKYEPGRGAPRVVARGAGAAATRIREEAAELRLPMVEDIPLARTVFRLCGIGEEIPSELFDAVAGVFVFVVGLKRRGIVSGIHRNPSAGRERVGVAV
>NZ_CP049935.1|WP_166122544.1|2772055_2774140_-|flagellar-biosynthesis-protein-FlhA
MKKARSARLSQIGIPGAVVAVVVLMVVPVPSMVLDLLLALNLTLSVLVLLVALRVTRPLDFAVFPSLLLVATLFRLALNVSATRLVLVDGFAGKVIEAFGHVVVGSSIVVGLVIFLILIVIQFVVITNGAGRVAEVAARFTLDAMPGKQMAIDADLNSGLIDEDQARQRRADVAAEADFYGAMDGASKFVKGDAIAAIVITLVNLIGGLVIGVAQNGQSIGDAVSTYSLLSVGDGLVSQIPALLLSMSTGIIVTRAATDRDMGGDILHQFGAQRGAIQLAGVVIMALALVPSLPKLPFLLVGGGALVLARSMPKLEEREAARKAQEAVEAKQSEPSPDSPEVLAQDIRVEPLELELAFDLISLVDTDNGGDLLGRVKALRRKLAMELGIVIPLVRTRDNLDLPSHTYAIRVHGVEVARAEAPGGHVLVIGDAINHLDGTPTREPVFGLEAKWVAAHLRGRAEALDGTVVDRSSVITTHLAETVRRHAADLLGREDVKLLVDAVRATHPQVVDELTPSPLSLGEVQRCLKGLLAEGVAIRDLVRIFEAISLRARVSTDPDGLVEAARLALGPAIAASHAVGGELHVLTFEPRLEQRLLEALRPSEAGVQLALDPFLAEQVVTEAARVSRVVEERGVQPVLVCAQPLRRPVRRLVESTAPQLAVLAYQELGGHLQLTTAGVVDVEPAGVVPVQAVG
>NZ_CP049935.1|WP_166122542.1|2771763_2772054_-|hypothetical-protein
MASRGRRVAHSPERFGFGALFGVLMFVPAGLLVYRGNLSVEDAVLRFGLAWTVAVMGVGVVASVLHGSPGGPVRPRAAAPARPAEASGPAEESPAP
>NZ_CP049935.1|WP_166122560.1|2779445_2779907_-|flagellar-basal-body-protein-FliL
MSTATAAAPAAHAEPAKKKKPLLLVIVVVLALAGGGGWYFLKGSSGDAAAEPVVESGPVVDLDAMTLNLSDGRYLKIGLSLEVTEEANAAAGSDGVNGAKARDAAISILGQHTYDQMLVPKQRAAAISALTTEVEKRYDGDVIDVYVTEFVMQ
>NZ_CP049935.1|WP_166124389.1|2779903_2780158_-|OmpA-family-protein
MSTARATTVLQFLLSQHVAGSRLSAAGYADQRPLATNDTTSGRARNRRVAVVVHSTDPSTSVAASVSSTSTPSTQSASPSGGSR
>NZ_CP049935.1|WP_166122562.1|2780804_2781572_-|motility-protein-A
MELATIGGVVLVFGAVFASLVMEGASPTSIILIPPIILVFVGSIGAAVSGGYLSDVMVIVKQLMKAFTAKAPKSDEAVAELIALADIARREGLLALEEKARSAEDPFLREGLEMTVDGTDADEIYDVLAARIKTRKKTDHLGIKFFADMGGYAPTIGIIGTVIGLIHVLSNLDKPEELGHLIAGAFVATLWGVMSANVMWLPFSSKLKRISEAEVAHLEMVLEGVMSIQAGTSPRVVEKRLRAVIAGDAPLEDAA
>NZ_CP049935.1|WP_166124390.1|2781573_2781843_-|flagellar-FlbD-family-protein
MIILTRRNGTRFGLNPDLIERVDETPDTVVLLVTGSRYVVQESLDDVVALMRDARASVLTAAEESGTGQPGSRPSAGRAALRAVRGMED
>NZ_CP049935.1|WP_166122564.1|2782067_2783294_-|flagellar-hook-protein-FlgE
MLRSLFSAVTGMRSHQTAMDVIGNNIANVNTAGFKSSQTQFQDTLSQALRAGGGGVNPAQVGLGVQVAGIATNFSQGSAQTTNRPSDLMISGDGFFVVQQAGGNVYSRAGAFSLDGQGNLTSPSGGVVQGWLAVDGVINTGTSMTGLRVPTGLIMAPTPSSSVDAGGNLSADAAIGATVVNGIDVFDQTGRSIPVTLTYTKTGTDTWTAAATVTGSGGATTTVGSATLAWNSTTMAFTPGSVAMTNASLAAAGFVFPGDVSINLAGDGTPLTQYAGASTATLRGQDGSAAGQLQSWGVGADGVITGSFSNGRTQSLGQVALAYFGNPEGLEKAGDSSFRASAASGQPAIGVPGTGGRGSIAAGRLEMSNVDLAQEFTNLVMIQRGFQANSRVVSASDEILQDLVNLKR
>NZ_CP049935.1|WP_166122566.1|2783357_2783789_-|flagellar-hook-capping-protein
MTTINTGATAAAAAAASAAAAPTSTGGSAIGTDAFLKLLVAQLRYQDPSKPMDSAAFMAQTAQMQMVESVNQLVTQNAAIIGNQNSMSALSLVGQDVTWTVDGVTKTGTVTGVKLDATGPRLVVGKDEVSLSVVSRVSQHGAA
>NZ_CP049935.1|WP_166122568.1|2783793_2784966_-|hypothetical-protein
MTTAVVPAAPPAVAAPGRPSRPAGSGDAFEQVLRAQSGPDATASGDGTSDPAGDAPTDTADRPADAAHPSDPGTAQATDPTAAPATDPAPVLPVPPLVTPPATAPAAGAPGGQGSSDTSVPDAAGAPAGIAAREPTTPAPAPTTGRPAPSAPDSPAPAGSPANPAQAGPVHVAHVPRPEGAPTVVAAPGVGTVSAETAAAQANPTNPVPQAEGPATPATPLQAVAQPQAAAPAAPVAPTAPTAPAAAPTPLFTQVVTAVTPLLTGPDGTHQLTVRLDPEGLGAVHVRLSVSGDEVRMHLVAADAGTREALRDGLGQLRTQLEDVGLRATHLDVATGGEPRQQQPGPGPEERQRLAVPAERSGSRHGPAPPVTPAPHRTTHRPDTRLDLRM
>NZ_CP049935.1|WP_166122570.1|2784965_2785991_-|transglycosylase-SLT-domain-containing-protein
MSVETSGPAALLARMAAIQSTIASVSGTATRAATGSPTGATGTSFDSVYGSALEGTGATSDSGLLAGAGGSDVGSRAVAAASQYLGVPYVWGGTNPRTGLDCSGLVQRAYADVGVHLPRVAADQARMGTAVPDLAHAQPGDLLAFNSPVTHIAIYLGDGKMIAAPKAGDVVKIQDVYKTPSAIRRIGASVETGVSAPIGASGLTGVSGLAGASASGAPAALQNLFASATARYGLPQGLLAAVAKAESGFDTGAVSPAGARGLMQLMPATARGLGVDPMVPAQAVDGAARMLARDLHRFGSVGLAVAAYNAGAGAVQRYGGVPPYTETQQYVRRVLGSMGAS
>NZ_CP049935.1|WP_166122572.1|2785987_2786425_-|hypothetical-protein
MSARTDRLATVLRVRTIQEEQRRGDLARAAAAQGRAAEAAAEAAARYGARDVCGVGVPLDTATFLATRQAETRRADGVSAAAGEHALAEGETERSRALLAEARTRTSGLERVLERAAEERRLELLAADQAVAEESGRARKGEGER
>NZ_CP049935.1|WP_166122574.1|2786421_2787723_-|FliI/YscN-family-ATPase
MSTTLHDELVAAARPRVTGRVTRAIGVGLEVSGLDVAVGEAVRVVGERGTILAEVVALDDGSARCMPVGELRGVRVGDRVEATGGPLRVPVGDGLVGRVVDALGRPIDGGPPLVGVSWVGSDGTPPPAMTRERITTQLGLGIRAMDTLVPCGRGQRMGIFAGSGVGKSSLLSMIVRGTDAPVTVLALVGERGREVREFVEHDLGPEGLARAVVVVATSDEPALVRLHAASTATRIAEWFRDQGRDVLLAMDSVTRVAMAQREVGLAAGEPPTTRGYPPSVFGVLPRLLERAGTAERGSITGLYTVLVEGDDMNDPIADAVRSILDGHVVLDRRLATSGHYPCIDVLESVSRANRALTDPAQRAAAGTLRSLLAARRDAKDLVEIGAYVAGTNPLVDRALAQSGAIDGFLRQDLDDVADARDSWSSLAALAGAL

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Crispr_ID: NZ_CP049935_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049935_9

3087486-3087597

Orphan

Consensus_repeat	Method
CCGACGAGGACGACCCCTGGGACGAGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049935_9

>merge|NZ_CP049935|9|3087486-3087597|CRISPRCasFinder
CCGACGAGGACGACCCCTGGGACGAGCCCGCCGGAACGATCGCCCCCGCTGCCGACAAGGAGGCGCCGGCCACGCCGGAACCCGCCGACGAGGACGACCCCTGGGACGAGCC

>NZ_CP049935|9|8|3087486-3087597|CRISPRCasFinder
CCGACGAGGACGACCCCTGGGACGAGCC	CGCCGGAACGATCGCCCCCGCTGCCGACAAGGAGGCGCCGGCCACGCCGGAACCCG
CCGACGAGGACGACCCCTGGGACGAGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049935.1\|WP_166123079.1\|3084372_3084720_-\|transcription-initiation-protein	unknown	unknown	gnl\|CDD\|226318
NZ_CP049935.1\|WP_166124410.1\|3090115_3090895_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224095
NZ_CP049935.1\|WP_166123071.1\|3078361_3078862_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166123087.1\|3092745_3093468_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|378820
NZ_CP049935.1\|WP_055810214.1\|3095590_3095788_-\|excisionase-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|200128
NZ_CP049935.1\|WP_166123096.1\|3097381_3097759_-\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NZ_CP049935.1\|WP_166123081.1\|3089064_3089985_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270324
NZ_CP049935.1\|WP_166123077.1\|3082011_3082941_-\|cysteine-synthase-A	unknown	unknown	gnl\|CDD\|273463
NZ_CP049935.1\|WP_166123073.1\|3078870_3081420_+\|CHAT-domain-containing-protein	unknown	unknown	gnl\|CDD\|378942
NZ_CP049935.1\|WP_166123063.1\|3074042_3074429_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380340
NZ_CP049935.1\|WP_166124408.1\|3083096_3084284_-\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|227277
NZ_CP049935.1\|WP_166123094.1\|3095811_3097266_-\|replication-initiation-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166123092.1\|3094487_3095591_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NZ_CP049935.1\|WP_166123067.1\|3076083_3077766_+\|S8/S53-family-peptidase	unknown	unknown	gnl\|CDD\|173787
NZ_CP049935.1\|WP_166123085.1\|3091540_3092680_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224050
NZ_CP049935.1\|WP_166123090.1\|3093650_3094226_-\|dCTP-deaminase	unknown	unknown	gnl\|CDD\|234753
NZ_CP049935.1\|WP_166123069.1\|3077762_3078365_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NZ_CP049935.1\|WP_166123075.1\|3081412_3082009_-\|serine-O-acetyltransferase	unknown	unknown	gnl\|CDD\|223975
NZ_CP049935.1\|WP_166123065.1\|3074869_3075250_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166123083.1\|3090891_3091539_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224095

Protein	Function_ID	Function_description	E-value
NZ_CP049935.1\|WP_166123079.1\|3084372_3084720_-\|transcription-initiation-protein	gnl\|CDD\|226318	COG3795, COG3795, Uncharacterized protein conserved in bacteria [Function unknown].	4.26009e-26
NZ_CP049935.1\|WP_166124410.1\|3090115_3090895_-\|ABC-transporter-permease-subunit	gnl\|CDD\|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	1.0796e-48
NZ_CP049935.1\|WP_166123087.1\|3092745_3093468_-\|alpha/beta-hydrolase	gnl\|CDD\|378820	pfam12146, Hydrolase_4, Serine aminopeptidase, S33. This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.	4.12282e-08
NZ_CP049935.1\|WP_055810214.1\|3095590_3095788_-\|excisionase-family-DNA-binding-protein	gnl\|CDD\|200128	TIGR01764, Probable_excisionase, DNA binding domain, excisionase family. An excisionase, or Xis protein, is a small protein that binds and promotes excisive recombination; it is not enzymatically active. This model represents a number of putative excisionases and related proteins from temperate phage, plasmids, and transposons, as well as DNA binding domains of other proteins, such as a DNA modification methylase. This model identifies mostly small proteins and N-terminal regions of large proteins, but some proteins appear to have two copies. This domain appears similar, in both sequence and predicted secondary structure (PSIPRED) to the MerR family of transcriptional regulators (pfam00376). [Unknown function, General].	2.07685e-10
NZ_CP049935.1\|WP_166123096.1\|3097381_3097759_-\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	4.23246e-16
NZ_CP049935.1\|WP_166123081.1\|3089064_3089985_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270324	cd13606, PBP2_ProX_like, Bacterial substrate-binding protein ProX of ABC-type osmoregulated transporter and its related proteins; the type 2 periplasmic-binding protein fold. This group includes periplasmic substrate-binding component of ABC transport systems from gram-negative and -positive bacteria that are involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	7.33522e-114
NZ_CP049935.1\|WP_166123077.1\|3082011_3082941_-\|cysteine-synthase-A	gnl\|CDD\|273463	TIGR01136, Cysteine_synthase, cysteine synthase. This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family].	1.58702e-164
NZ_CP049935.1\|WP_166123073.1\|3078870_3081420_+\|CHAT-domain-containing-protein	gnl\|CDD\|378942	pfam12770, CHAT, CHAT domain. These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins.	5.94595e-22
NZ_CP049935.1\|WP_166123063.1\|3074042_3074429_-\|cupin-domain-containing-protein	gnl\|CDD\|380340	cd02210, cupin_BLR2406-like, Bradyrhizobium japonicum BLR2406 and related proteins, cupin domain. This family includes bacterial and fungal proteins homologous to BLR2406, a Bradyrhizobium japonicum protein of unknown function with a cupin beta barrel domain. Proteins in this subfamily appear to align closest to RmlC carbohydrate epimerase which is involved in dTDP-L-rhamnose production, and belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.17419e-13
NZ_CP049935.1\|WP_166124408.1\|3083096_3084284_-\|RNA-polymerase-sigma-factor	gnl\|CDD\|227277	COG4941, COG4941, Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription].	8.34343e-121
NZ_CP049935.1\|WP_166123092.1\|3094487_3095591_-\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	1.63649e-22
NZ_CP049935.1\|WP_166123085.1\|3091540_3092680_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224050	COG1125, OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism].	1.24181e-135
NZ_CP049935.1\|WP_166123090.1\|3093650_3094226_-\|dCTP-deaminase	gnl\|CDD\|234753	PRK00416, dcd, deoxycytidine triphosphate deaminase; Reviewed.	7.2319e-94
NZ_CP049935.1\|WP_166123069.1\|3077762_3078365_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	1.42929e-21
NZ_CP049935.1\|WP_166123075.1\|3081412_3082009_-\|serine-O-acetyltransferase	gnl\|CDD\|223975	COG1045, CysE, Serine acetyltransferase [Amino acid transport and metabolism].	2.54968e-82
NZ_CP049935.1\|WP_166123067.1\|3076083_3077766_+\|S8/S53-family-peptidase	gnl\|CDD\|173787	cd00306, Peptidases_S8_S53, Peptidase domain in the S8 and S53 families. Members of the peptidases S8 (subtilisin and kexin) and S53 (sedolisin) family include endopeptidases and exopeptidases. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53, it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium; some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values.	1.66357e-17
NZ_CP049935.1\|WP_166123083.1\|3090891_3091539_-\|ABC-transporter-permease	gnl\|CDD\|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	1.18524e-37

>NZ_CP049935.1|WP_166123079.1|3084372_3084720_-|transcription-initiation-protein
MTQYAAMIYSRDVDWTLPEYAAETAEYGAFAEAAGAVIRGGAALYPTSTATTVRVEAKGGTPLTTDGPYAETKEALTGFYLLECADLDEAVKVAATIPGAWDGAVEVRPVIEFPM
>NZ_CP049935.1|WP_166124408.1|3083096_3084284_-|RNA-polymerase-sigma-factor
MVRVAGRDVLATLARWTGNLALAEDAVQDASVRALLTWPRDGIPDTPVAWLRTTARRCAVDQIRREAARGPKELLATGPAVDVVLAEADPGPEVVEDDLLRLVFTCCHPSLGPGTRVALALRTLCGLGTEEVARALLVSEPAMAKRLTRARQKIRLAGIPYRVPSEDDLPERWDTVLATTYLMFNEGYAATAGPELTRPALVAEALRLARLLRRLRPGDPGATGLLALILLQDSRRAARTDADGAAVLLADQDRSRWDRAAIAEAVPLVGEGLRLSPAHPDPYVVQAAIAACHALAPSWADTDWTAIESWYEVLLRVDDGPVVRLNHAVAVAEARGPQAGLALVDAIEGLGDYPLWHASRAALLRRLDRPEEAAAADDEARRLPLNAVQRDLLDR
>NZ_CP049935.1|WP_166123077.1|3082011_3082941_-|cysteine-synthase-A
MPILDDVTQAVGNTPLVRLNRIIEGEATVAAKLEFYNPASSVKDRIGVAIIDAAEASGQLKPGGTVVEATSGNTGIALAMVGAARGYKIVLAMPETMSKERRALLRAYGAELVLTPGSEGMKGAVTKADEIVAEREGAVLARQFANAANPEVHRRTTAEEIWKDTDGGVDIVVAGIGTGGTITGVGEVLKSRKPGVQIVAVEPEESPILNGGAPGPHKIQGIGANFVPEILNTEIYDEVIDVNAQTSVEWARRAATEEGLLVGISSGAALAAANQVASRPENAGKTIVVIIPSFGERYLSTILFEGLVD
>NZ_CP049935.1|WP_166123075.1|3081412_3082009_-|serine-O-acetyltransferase
MSLLQQARATVREDLDAAMRRDPAAESRADVAFNSPGLHAIWSYRLAHRLWDKGPQWRPAARLLSTFTRAVTGVEIHPGARIGRRFFIDHGMGVVIGATAVVGDDVMLYHGVTLGGRSLERGTKRHPTLGDRVTVGTGARILGDIEVGDDVQIGANSVVVKPVPSGAVATGIPAVVRFPATSEQDPYDALFAEPALFI
>NZ_CP049935.1|WP_166123073.1|3078870_3081420_+|CHAT-domain-containing-protein
MPGTAVAQELSRAVRAAVRRNGVGDFDGAAHLLVEALEVADTMPESDRAFWRARLLVTLSYATFETRGEAAATVQLDEARRLAEQIGSRRLEALTHVQEANLRARGTAWQAALRAATAASGFTDVLEPEELYALHLNRGFAHLGVLQLDECERDLDAALAIADREGVEELRYKAIHNRGCLAYVRGDLPRALTIMREADELPVGVARDRNRLDQAQVLIDAGLVDRARSVLEDALAGSARAHHLVQSGAIRLDLARCAVLLDDTAGAREHAEAALRTFEDLGARDRSRRARLVLAQVTLLGDDDALDDVDALLGDWGSAPTADLDAATATRLRAEVALRRGHTRDCLDLLRELGPGARSVEARLHEDYLHAAAAAALEDHRSSRARCRSASTRLARQQGRSQSLEVRAAMAVHARRLAAFDVDQALRSGRPSTVFASIERWRAASQRIPPVLPSGDARTDELMTELRAAQQARGSVARASRSALDARIADLTRRVERREWERRTDADAGGAATPVSTARAMALAGAHRTVVSLFAAGDDLHAVVLGSRLTQHRVGPLAPVLDAAAVLVRDLRARAVSRRVPALAVALEAAVVDAARRLDDLLLGPGSGLAGLLAPQVVVVPLRALASVPWNVLPSLRGREVVVARSVTRWVRSTEASPEPPTLAVAVGPGLSHALEEGRRIREVWGTGEGGGLSSAADAVHALASATLVHLAAHGVHSTANPMFSTLRMADGPLFLHELPSPLRAEHVVLSACDVGQAHVRHGEEALGMSAGLLSLGAHSVLASVAPVDDEETGTAMVGYHRHLSTGASAAAALAATIAEHPVASSFAVYGADWSAGSVRSVRPAGPVR
>NZ_CP049935.1|WP_166123071.1|3078361_3078862_+|hypothetical-protein
MNAFDDREDHLARGGIDAIDEAVLADLRAALEAIDPVPPTLTDDVKFRLTVAALEADVAEIVATSSELAGVRGTSYDRATSVTFTSGALSAMVTIDEEGTRPASISGWTSEGGVEVELRERSRTRTTTSDSHGRFSFTDVQRGLVHFVFRHGSAGVAPVITPAIEI
>NZ_CP049935.1|WP_166123069.1|3077762_3078365_+|sigma-70-family-RNA-polymerase-sigma-factor
MTVTGSGTDGLAVRAAEAFAGYRAGDPARMSDLVDEVTPLLWHIARQQGLSQPAAEDVVQTAWMRLVEHQARVIDELGVLKWLITTTKREAWRVARTSRREDVVDEVDRVTEAPRTDPTPSPEQALLADEERGLVWRHFEALPERCRTLLRAIAFTDKPDYASVAEALGMPIGSIGPTRGRCLAKLRVLLDSDPAWRGTA
>NZ_CP049935.1|WP_166123067.1|3076083_3077766_+|S8/S53-family-peptidase
MPEPTPPPFGPRGLRPEILRAREEEVERRRRHPDPPVRDTVPHGPIPSYSVPDTAIRRFGARVLDPTTAVTRGDEPPPQATVYIPDLVLVPGKPESGLADALGPINAALEKAQLRVRAEVDERIPPPSQMSDERLAAALERYASDLGSASHTAVRLTSTDSGPHAPIDAWTVLQTLRGQGIGTDGTYGLVHVLQPSGWVTGVGETHGVGETHGVGETHGVGETHGVGAVLSLTGRMPVVWAADDPAGGTYDGPVVAVLDTGLGDHPWFRAGVLSGNLYDTPMGLQHSAAEDPEVYGMTLDLINGVMDPLAGHGTFIAGLIRQRCPSARILPVPVMYGDGAADERDLIRALELLLVRQRLLLDDDVPEDLRPEGDPVDVLNLSLGYYHEQPGAVEREGALFSVLAALADTGVCIVAGAGNGSTDVEFWPAALAGRPEPKVPITAIGSLNPDSVTVSSFSNTGSWVSAYRSGAAVVSTMPVTFNAAERGAVFREGSRYPARGTIDLDDYSGGFGIWSGTSFSAPAFAGELARALATKGATAADRVERARDAVGAALKQRLAR
>NZ_CP049935.1|WP_166123065.1|3074869_3075250_+|hypothetical-protein
MSTFAMTAPNPLVRVLLAVTSLGRGTVELTDETLSVHLGIGWQSRMPRSSIVSAGRDPRHRISIGAHGWGGTWLVNTSGHDLVRLALHPDQRGRCLGIPVRVRTLRVSLAEPDAFLAALDAPAHAA
>NZ_CP049935.1|WP_166123063.1|3074042_3074429_-|cupin-domain-containing-protein
MTEREPVRVVRDDELVEADPTSGMLRRRAFEVPGLWAGQVVTDPGAVSGWHHHDSNSSVLYVVRGVLRLECEGVEGWVDATPGSYVQVPAFTVHRESNPGREPSLAVIARAGVGIPTVNVDAPPPPHR
>NZ_CP049935.1|WP_166123081.1|3089064_3089985_-|ABC-transporter-substrate-binding-protein
MKRRTVLSTVAVVAALGLSACGGGGSDPLASDAPSGGSSGASSGSIVVGGADFSESTLLAEVYAGALRAKGIDATTKTNIGAREIYLRALEDNSVQVFPEYTGALAVFYDKSYSGTDATEVYDKAKSVIPKTLTVLDKSAAEDVDSLAVTKKTAESKNLKTIEDLKAVSGDMTLAAQPEFKQRPQGVVGLEKVYGVTFGTFRPLTGQAVLQALVNGQADVANVFSTDPGIAANDLVVLEDTKKVFGSQNIVPLVRADKADQVKDALNAVSAKLTTDAVTQMLKQTDIDKKDPKAVAEEFLKANGLG
>NZ_CP049935.1|WP_166124410.1|3090115_3090895_-|ABC-transporter-permease-subunit
MIGSLFSWLLDPAHWSGPDGILTRLLEHLWYSVLAMVIALAIALPLGLWIGHTGRMRWLVTATNAARAVPTLGLLFAFALWLGPALRGNLAFLLPSTVVLVLLAVPPLLAGTYAGVEAVDPAARDAARGVGMTGWQVLRQVELPCALPLVMSGVRTASLQVVATATIAALIGLGGLGRLLVDGIAFGDYPQAAAGALLVAVLAVLLEGLLALLQRRLVSPGLARTRRPVGGSRNDDDAAAVEANARLPVGQGGIPGGSS
>NZ_CP049935.1|WP_166123083.1|3090891_3091539_-|ABC-transporter-permease
MDWLADNWRTVLDLSLSHLYLAGVPLVVGLVLSLPLGWAAKRWRGSYPAVVTTTGLLYTIPSLALFVIMPLVLGTKILDPVNVVVAMTIYTVALLARTVADGLLSVPDHVEQAATAMGYRGLRRLFGVELPLAVPVIAAGLRVAAVSNVSIVSIASVVGVSQLGNLLVDGYRRIIWGELLTGIVATMVLALLLDLVIQTLARTLTPWRRAAGARS
>NZ_CP049935.1|WP_166123085.1|3091540_3092680_-|ATP-binding-cassette-domain-containing-protein
MIRFDGVTKQYPDGTVAVDDLSLTAPTGKITVLVGPSGCGKTTSLRMVNRMIEPTRGSISLDGQDTGRMPQAELRRGIGYVIQHAGLFPHRTVLDNIGTVPRLLGWDRKRTAERSRELLERVGLELHLGDRYPAQLSGGQQQRVGVARALAADPPVMLMDEPFSAVDPIVRDQLQDEFLRLQDELGKTIVFVTHDIDEAIKLGDQVAVLRVGGTLAQVAEPSYLLAHPADDFVADFVGRDRGYRALQFQATPRLPLRSERTVVLGERPEGSAAWLLVVDDDRHPLGWVEPARIGGRAVEDSDLHRGGTVARAGGTLRGALDAALSSPSRRGVVVDDSGSLVGTVLAHEVLSAIEDTDRPERDEDDPVHGGAVAVAADEA
>NZ_CP049935.1|WP_166123087.1|3092745_3093468_-|alpha/beta-hydrolase
MPDRPTSTPEPALESHPAPGHTPTTDLATALLSPEGGGGAELRGHVPEAPVGVVLVLHGGAERSHEPVRWRRLAVVRMLPFATALQHAADGRLAVLRLKYRVRGWNGLEQDPVHDARWALERIRRVLPGVPVALVGHSMGGRVALQLAAEPDVAAVAALAPWVEDDARQPRSDVPVLLMHGSGDRMTDPRRTAVIARRWEESGADVTHLRVPGEKHAMLRHASYWHRTVTDFVTGALLGR
>NZ_CP049935.1|WP_166123090.1|3093650_3094226_-|dCTP-deaminase
MLLSDRDIRAEVEAGRVVLDPWDPDMIQPSSVDVRLDKFFRLFDNHKYQVIDPAQDQADLTRLVEVEPHEGFVLHPGEFVLGSTLETVSLPDDLAARVEGKSSLGRLGLLTHATAGFVDPGFTGHVTLELSNVATLPIMLWPGMKIGQLAFFRLSSPAESPYGSEGYGSHYQGQRGPTASRSFQNFHRADV
>NZ_CP049935.1|WP_166123092.1|3094487_3095591_-|site-specific-integrase
MGKRVRGSIRRLPSGRWQVRYTGLDGLRRTLEQTHRTKAEAEAAYAIVAADMATGRWVDPSLAGVTFGTYAARWVAERATITGRTRELYGTLLRLHLAPYLGEVQLRYLSPALVRRWRQGRQDAGVGASTIAKAYRLLRSIMATAVDDEVILRNPCRIRGAGSEVASERPILTPAEVARLAEVIEPRYRLVVLLAVYGSLRWGELMGLQRGDLDLDLMTLTVRRSVSEVGGRLVVKGPKSRAGLRTIALPLGLREDIEQHLAAFAEDGPEGRLFVGQRGNTLHRSNWTPVWSAARSAADLDPRVHLHDLRHTGNHFAAASGASTRELMHRMGHASMRAALIYQHATAERDARIAATLDQVFSRGGGR
>NZ_CP049935.1|WP_055810214.1|3095590_3095788_-|excisionase-family-DNA-binding-protein
MQRLLTVHEVAEVLGTADGFVRQLVAARRIRFLRVGKHLRFPVSAVPEYLAAVTVEPLPSRGRSA
>NZ_CP049935.1|WP_166123094.1|3095811_3097266_-|replication-initiation-protein
MGLLGRFADGSMDAFADTLAAVHNCARPVRLAGSSTTIDARTGEVLSTFRSTDAPLGVLFRPCGNRRAHVCPACSRTYARDTFALISAGVAGGKTVPEQVAGNPLLFATFTAPSFGLVHGHRGGRPCRPRRRDDRTRCVHGRPLWCTAIHEPGDERSGAPLCPDCHDTASAVLWQWHAPELWRRTTIALRRAVAAHLGVTESGLGEHASIQYAKVAEYQGRGLVHFHALIRLDGPADAGIGAPSPDALDGPALAALVRDTAPGVTVLAEAVDDQDTPRVLAWGAQLDVRVVTAGHRVDDPTAALTPGQVAGYLAKYATKDVSGLHGEGQQRPHIAAFRAACAALADRAARHHHEDHDYQRMGRWVHMLGFRGHFGTKSRRYSVTLGALRRARARWQAMAAESRRTGEPIDTRDLERRLLADDDEESTVVVGSWTYLGTGWRDAAEEALALAAAARAREYDQWRAERRDGHHTGTHHSGGTTSTR
>NZ_CP049935.1|WP_166123096.1|3097381_3097759_-|WhiB-family-transcriptional-regulator
MTGPQAPDRVALRPWGVPLPYVTTSAAVLDELDGIRWRERGSCAADPDGGWFEDLRAPAAHRARSICSGCPIRRKCLAAALLYGEEFGIWGGLDPDQRRPLDGALRHGEPLGRVVLGALHTDRAA

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Crispr_ID: NZ_CP049935_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049935_10

3148538-3148629

Orphan

Consensus_repeat	Method
CCACGAGAGGGCCCGGCATCACCTCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049935_10

>merge|NZ_CP049935|10|3148538-3148629|CRISPRCasFinder
CCACGAGAGGGCCCGGCATCACCTCGACCCGCCGAACACTCCAGCTCGTTCGAGGTGAAGGGGCACCACGAGAGGGACCGGCATCACCTCGA

>NZ_CP049935|10|9|3148538-3148629|CRISPRCasFinder
CCACGAGAGGGCCCGGCATCACCTCGA	CCCGCCGAACACTCCAGCTCGTTCGAGGTGAAGGGGCA
CCACGAGAGGGACCGGCATCACCTCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049935.1\|WP_166123176.1\|3144084_3144582_+\|BlaI/MecI/CopY-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367747
NZ_CP049935.1\|WP_166123185.1\|3149464_3149950_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166123190.1\|3155865_3156381_+\|low-molecular-weight-phosphotyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|319971
NZ_CP049935.1\|WP_166124414.1\|3157967_3158354_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_CP049935.1\|WP_166123191.1\|3158422_3159175_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166123180.1\|3145463_3145817_+\|GatB/YqeY-domain-containing-protein	unknown	unknown	gnl\|CDD\|370480
NZ_CP049935.1\|WP_166123186.1\|3150058_3151375_+\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	unknown	unknown	gnl\|CDD\|273109
NZ_CP049935.1\|WP_166124412.1\|3151365_3151704_-\|DUF1003-domain-containing-protein	unknown	unknown	gnl\|CDD\|377629
NZ_CP049935.1\|WP_166123178.1\|3144624_3145467_+\|M56-family-metallopeptidase	unknown	unknown	gnl\|CDD\|320685
NZ_CP049935.1\|WP_166123184.1\|3148254_3148500_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166124413.1\|3155065_3155755_+\|ATP-dependent-dethiobiotin-synthetase-BioD	unknown	unknown	gnl\|CDD\|234625
NZ_CP049935.1\|WP_166123170.1\|3139844_3140876_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|376764
NZ_CP049935.1\|WP_166123183.1\|3147236_3148250_+\|biotin-synthase-BioB	unknown	unknown	gnl\|CDD\|235755
NZ_CP049935.1\|WP_166123189.1\|3152741_3153695_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049935.1\|WP_166117790.1\|3145824_3146325_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP049935.1\|WP_166123174.1\|3142490_3144137_+\|thiol-reductant-ABC-exporter-subunit-CydC	unknown	unknown	gnl\|CDD\|274331
NZ_CP049935.1\|WP_166123187.1\|3151897_3152314_-\|PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274679
NZ_CP049935.1\|WP_166123188.1\|3152370_3152745_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224639
NZ_CP049935.1\|WP_166123182.1\|3146447_3147179_+\|AIM24-family-protein	unknown	unknown	gnl\|CDD\|224924
NZ_CP049935.1\|WP_166123172.1\|3140895_3142494_+\|thiol-reductant-ABC-exporter-subunit-CydD	unknown	unknown	gnl\|CDD\|227321

Protein	Function_ID	Function_description	E-value
NZ_CP049935.1\|WP_166123176.1\|3144084_3144582_+\|BlaI/MecI/CopY-family-transcriptional-regulator	gnl\|CDD\|367747	pfam03965, Penicillinase_R, Penicillinase repressor. The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.	1.02731e-27
NZ_CP049935.1\|WP_166124412.1\|3151365_3151704_-\|DUF1003-domain-containing-protein	gnl\|CDD\|377629	pfam06210, DUF1003, Protein of unknown function (DUF1003). This family consists of several hypothetical bacterial proteins of unknown function.	1.4471e-25
NZ_CP049935.1\|WP_166124414.1\|3157967_3158354_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.79656e-13
NZ_CP049935.1\|WP_166123180.1\|3145463_3145817_+\|GatB/YqeY-domain-containing-protein	gnl\|CDD\|370480	pfam09424, YqeY, Yqey-like protein. The function of this domain found in the YqeY protein is uncertain.	7.90618e-06
NZ_CP049935.1\|WP_166123186.1\|3150058_3151375_+\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	gnl\|CDD\|273109	TIGR00508, hypothetical_protein_DESPIG_00326, adenosylmethionine-8-amino-7-oxononanoate transaminase. All members of the seed alignment have been demonstrated experimentally to act as EC 2.6.1.62, an enzyme in the biotin biosynthetic pathway. Alternate names include 7,8-diaminopelargonic acid aminotransferase, DAPA aminotransferase, and adenosylmethionine-8-amino-7-oxononanoate aminotransferase. The gene symbol is bioA in E. coli and BIO3 in S. cerevisiae. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin].	0
NZ_CP049935.1\|WP_166123190.1\|3155865_3156381_+\|low-molecular-weight-phosphotyrosine-protein-phosphatase	gnl\|CDD\|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	9.96341e-56
NZ_CP049935.1\|WP_166123178.1\|3144624_3145467_+\|M56-family-metallopeptidase	gnl\|CDD\|320685	cd07326, M56_BlaR1_MecR1_like, Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase. This family contains peptidase M56, which includes zinc metalloprotease domain in MecR1 as well as BlaR1. MecR1 is a transmembrane beta-lactam sensor/signal transducer protein that regulates the expression of an altered penicillin-binding protein PBP2a, which resists inactivation by beta-lactam antibiotics, in methicillin-resistant Staphylococcus aureus (MRSA). BlaR1 regulates the inducible expression of a class A beta-lactamase that hydrolytically destroys certain ?-lactam antibiotics in MRSA. Both, MecR1 and BlaR1, are transmembrane proteins that consist of four transmembrane helices, a cytoplasmic zinc protease domain, and the soluble C-terminal extracellular sensor domain, and are highly similar in sequence and function. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. All members contain the zinc metalloprotease motif (HEXXH). Homologs of this peptidase domain are also found in a number of other bacterial genome sequences, most of which are as yet uncharacterized.	7.25248e-26
NZ_CP049935.1\|WP_166124413.1\|3155065_3155755_+\|ATP-dependent-dethiobiotin-synthetase-BioD	gnl\|CDD\|234625	PRK00090, bioD, ATP-dependent dethiobiotin synthetase BioD.	2.80297e-59
NZ_CP049935.1\|WP_166123170.1\|3139844_3140876_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	gnl\|CDD\|376764	pfam02322, Cyt_bd_oxida_II, Cytochrome bd terminal oxidase subunit II. This family consists of cytochrome bd type terminal oxidases that catalyze quinol-dependent, Na+-independent oxygen uptake. Members of this family are integral membrane proteins and contain a protohaem IX centre B558. One member of the family, Klebsiella pneumoniae CydB, is implicated in having an important role in micro-aerobic nitrogen fixation in the enteric bacterium Klebsiella pneumoniae. The family forms an integral functional unit with subunit I, family Bac_Ubq_Cox, pfam01654.	2.66218e-109
NZ_CP049935.1\|WP_166123183.1\|3147236_3148250_+\|biotin-synthase-BioB	gnl\|CDD\|235755	PRK06256, PRK06256, biotin synthase; Validated.	0
NZ_CP049935.1\|WP_166117790.1\|3145824_3146325_-\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	8.09721e-07
NZ_CP049935.1\|WP_166123174.1\|3142490_3144137_+\|thiol-reductant-ABC-exporter-subunit-CydC	gnl\|CDD\|274331	TIGR02868, ABC_transporter_ATP-binding_protein, thiol reductant ABC exporter, CydC subunit. The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex.	2.10372e-108
NZ_CP049935.1\|WP_166123187.1\|3151897_3152314_-\|PPOX-class-F420-dependent-oxidoreductase	gnl\|CDD\|274679	TIGR03618, Rv1155_F420, PPOX class probable F420-dependent enzyme. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity].	2.30806e-13
NZ_CP049935.1\|WP_166123188.1\|3152370_3152745_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224639	COG1725, COG1725, Predicted transcriptional regulators [Transcription].	2.39032e-28
NZ_CP049935.1\|WP_166123182.1\|3146447_3147179_+\|AIM24-family-protein	gnl\|CDD\|224924	COG2013, COG2013, Uncharacterized conserved protein [Function unknown].	1.62107e-32
NZ_CP049935.1\|WP_166123172.1\|3140895_3142494_+\|thiol-reductant-ABC-exporter-subunit-CydD	gnl\|CDD\|227321	COG4988, CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones].	4.09619e-137

>NZ_CP049935.1|WP_166123184.1|3148254_3148500_+|hypothetical-protein
MVFADAGAHEPVARGEDPGAWCGQCGLGVGDGDHARCAVRAELEPPRYCIHCRRRMKVQVTPGAWTATCIEHGSVERSTWA
>NZ_CP049935.1|WP_166123183.1|3147236_3148250_+|biotin-synthase-BioB
MTAQVTGTDILDVAREQVLGRGVPLTEEQVLEVLRTGDDRLQDLLALAHEVRMTYQGPAVEVEGIVSLKTGGCPEDCHFCSQSGQFTSPVRSVWLNIPELVRAAKQTAATGASEFCIVAAVRGPDARLMEQMREGVAAIRAAVDIQVAASLGMLTQEQVDELVDMGVHRYNHNLEAGRSYFPQVVTTHSFDERLETCRMVKESGMELCCGGLVGMGETLEQRAELAAQLGELEPHEVPLNFLNPRPGTPFGDLEPMSTNDALRTIAAFRLALPRTILRYAGGRELTLGDLGTRDGLLGGINAVIVGNYLTTLGRDPREDLALLDELEMPIKALNETF
>NZ_CP049935.1|WP_166123182.1|3146447_3147179_+|AIM24-family-protein
MTIHGSLFTDFKEKESRDPFSLQNKKLLKVEMQYGPVQAKTGSMVAYQGDVRFANKGSGGMGKMFKAAVTGEGVKMMECSGSGELFLADLASEVQVMYLENDAISVNGNNVLAFSSSIQWDIHRIQARGAAMTGGLYNVSLRGTGYVAVTTKGDPIALDVASAPTFADAQAVVLWTSGVSMDVRVDTGGFGSMIRGGTGELLQMAFGGQGYVLVQPSESVNEGGHQSGGNQQGPGGMLGQFLN
>NZ_CP049935.1|WP_166117790.1|3145824_3146325_-|hypothetical-protein
MSFFEKAKAAASDLAAKADVAMTNAGVNVPGMGGDKALRDLGVIAWLDATGRPVADADRERVMATLRDLETQGRLGALTVSPPAPAYGTPPPPPGAAAAGAAPAAPPPPPRPRSGPAPAAVGAPGSSGTAGRAARPGGTAAGRGTAAAPAAQLGLSPAPPRRKTPR
>NZ_CP049935.1|WP_166123180.1|3145463_3145817_+|GatB/YqeY-domain-containing-protein
MSQDLRQSLAAALRPAMRARDSTAVAALRSALAAVANAEALPVPDAPAAGAIEQARVGVGAADAPRLELGEDDVRRIVRAEVTERESAAEVMAGHGRHDDVQRLRAEAAVLREHLGD
>NZ_CP049935.1|WP_166123178.1|3144624_3145467_+|M56-family-metallopeptidase
MVPLALGVLAVLLVWVTPAVLARQLPFRHAPRAALVAWQSVSLGGMLAAVFVAPAAVVVLAGRDGIARHPWLVAVGAVVSGAVLLRVAVSGHLVGTRVRAARARHRDLVDIVAEHERDGLRVLQHPTATAYCIPGRSSRVVLSQGVLDTLPPPELAAVIAHEKAHLRARHDLLLEFFTVLHESVPSAFRSRRALAEVRLLVEALADRAAVRTSGEVATARALVAIAESRSPDAAMGAGTSAPVRMQLLVAGPRPELAAVAYLIAVAALLAPLGLLSLVLG
>NZ_CP049935.1|WP_166123176.1|3144084_3144582_+|BlaI/MecI/CopY-family-transcriptional-regulator
MPSSTSATVPRRPPRRSSPVPHSTSAPRLGDLERVVMERLWEAGATDGATVREVHEALEKHREIAYTTVMTVLDRLAKKELVTREREGRAWRYYPADTREAMTAQSMRRTMDDMDLTDRRAALLHFLDGASSAEIDDLKAALAEVEARAGNGEETARRLRDRLRR
>NZ_CP049935.1|WP_166123174.1|3142490_3144137_+|thiol-reductant-ABC-exporter-subunit-CydC
MSAGPVVRPTRATVVGGLLGGAATSAGIALTATSGWLIVRASERPVILTLLAAIVAVRAFGMARPFFRYLERVVSHDAALADLAERRSSVYAALVPLTPARLGRRSRSQVLTGVVDDLTDVVEAQVRVTVPVLSSAVAGLLATALTAWFAPAVGLVVAALLLVLALGCLLAWRVESRSRDELLAARAETARIGDLVARQAGELRAIGAQDAALGWLDDAHAALRVAVRRQSRGRAGVAALILLATAAATVSAAVLVDPSAVGAPVAALLVLVPVAVGEALAPLVDTMRALARAQGSSARLDALLDQEPAVHDPDHPDPGPGVGPQHGPHVRLEGASASWTGAADQLAPTDLDLVPGRHVAVVGPNGSGKSTLLALLARTLDVSGGRHTVDGTDVRARPLAEVRSDVAVVDDEPHVFATTLAENLRLARPGADDAAVRHALGLAGLGTWADALPDGLATRLGTGGRGLSGGERTRLGVARAVLADRPVVLLDEPAAHLDHPTATAVLDDVLDATRDRSVVLVSHRAEALHRLDAVLDLGDRPASPTTKE
>NZ_CP049935.1|WP_166123172.1|3140895_3142494_+|thiol-reductant-ABC-exporter-subunit-CydD
MRPFDPRVLAVAPAARRPVALLAAVGVAQGAATIGTAFALAALVVAVVEGAGLGGPVAWLTGLLVVRAGLGWMSERVAAWAGVEVTAALRTVLLRRWLDAPAEQRPDPDRGATLSAQGVAAIEPYAARFLPALVAGAVVPVLAVAALVWVDWLSALVVVLTLPLLPLFAALIGAATRDETEKRWAALSSLAGHFVDVMRGLPTLVGYGRAERQVEVITDVSHRHRRATMRTLRLAFMSSAALELLASISVAIVAVTVGLRLTHGTVTLQTGLLAILLAPEAYWPIRRVGAEFHNAADGAEAVAAVLADVTTDPAPPARGPSSPSGPDELGAAARAVTYAYPGAPDPVLHGVDLEAGPGLTVVTGPSGVGKSTLLELLAGLRTPSSGEVVAGRAHLVTQRPFLPAGTLRDALRLGTDAPDAALWEALRRVGLEGFVAGLPEALGTRLGDDGVGLSAGQRARVALARATLSSTPVLLVDEPTAHLDAESSTLVADLLRDLAERRTVVAVTHRPELVRVADQHVVLTRAGAEVHP
>NZ_CP049935.1|WP_166123170.1|3139844_3140876_+|cytochrome-d-ubiquinol-oxidase-subunit-II
MDALQLVWFGLIGLLWAGYLVLEGFDFGVGALLPVLGKGTDAEDTEKRRRVMLTTIGPHWDGNEVWLLTAGGATFAAFPEWYATMFSAFYLPLLLVLVALIVRNMGFEYRGKRDDATWRARWDAAIIGGSVLAPLLVGVALTNVVRGVPLDAKSEYAGNFFTLLNPLSLLGGLTVLALSLTHGAFFLALKTSGTIREDARRMGTTLGLATAGLAVVTLLWLGFATGSVWSWVTTVVAAGSLLAAIFANTRGREGWAFIGTAVTAAMAVATYFLALYPDVMPSTLSGGRSLTIENASSSPMTLTIMTWAAVVFTPIVLLYTAYTYYTFRKRIGTQHIPEPVAVS
>NZ_CP049935.1|WP_166123185.1|3149464_3149950_+|hypothetical-protein
MSGAVERARADLEAGRPWMARDRLTSVIQHRTDDELVDLLAEVYLTMLDVPAAGALWFATGRDDEVARDAVAVWADRFPSDDARWSSIPRPLRTTDGSPGLEDLRRRLSARPRGERRPPDIPEPESRAEEMLAPALLLAGVLVLVAMVGIGLWTTWHWIWT
>NZ_CP049935.1|WP_166123186.1|3150058_3151375_+|adenosylmethionine--8-amino-7-oxononanoate-transaminase
MDADALADLRAFDRAHVWHPYSSALAPGDPYVVESAEGVRLRLRDRDGRTLDVVDAMSSWWCAVHGYRVPELDAAVRGQLGAMAHVMFGGLTHAPAVDLCRRLLTLAPSGLEHVFLADSGSVSVEVAMKAALQLHLAAGERRTRFLTVRGGYHGDTFSPMSVTDPVGGMHSLFRGVLPEHVFAPRPPAGVDLPDDDPELVDWERTTRDLFSQNASDIAAVIVEPVLQGAGGMHVYPPRVLDVLHDLAREHGALVIHDEIATGFHRTGPLWAGDRAQGAPDILCVGKALTGGYLTLAAMLCTREVAEGVSRSEAGGLMHGPTFMANPLACAVANANLDLLATRDTVAEVTRIESGLREGLSPAADLESVVDVRVLGAVGVVQLREPVRVAEVTAAALARGVWVRPFRDLVYTMPPYVTDEDDLAVVTSGLVGAVADVHG
>NZ_CP049935.1|WP_166124412.1|3151365_3151704_-|DUF1003-domain-containing-protein
MGSWRFVFAFVGFMAVWALVNSLTRGWDPYPFILLNLFLSMLAGLQGAILLIAAKRQDAIAADLAQHDYDTNVAAKKDVEVLLEINATQLEILRTLQDDLRVRIEALERRQP
>NZ_CP049935.1|WP_166123187.1|3151897_3152314_-|PPOX-class-F420-dependent-oxidoreductase
MPRPPLPDDVAELFRRPNPAVVAVLLPSGAPMSVATWYLVEDDGTVLLNMDAERARVSWMREHPEVALTALEEGSWYTHVSIRGRVVRWEEDREKALADIDRLSRHYGGQDYPTRDRARISCWVEVTHWHGWGAAKAD
>NZ_CP049935.1|WP_166123188.1|3152370_3152745_-|GntR-family-transcriptional-regulator
MTLQAVTVDVLDPTPPYEQLRRQLADLVGSGVLAPGDRLPPVRQLAADLGLAAGTVARTYRELEQAGYVRSRRGGGTRVAPAPPATATPQQALEDAAAAYLERAAVLGIPADEAVATVRRVAGA
>NZ_CP049935.1|WP_166123189.1|3152741_3153695_-|hypothetical-protein
MGIGISVLALPVAVVAFAVALVRRRTVTVGVNEHPDLVRIAGRTRAWRVVGLLLGILAGGLLLVLGQRVDALGRLTALAPAAVGAGVLLGTIVGELTARPAVGVRRAAVVETRTVRGLLPRTATGLLVVAAAVLAGTLAVGAAWGAPDDLGRAGRSFTESCQRVVDGVYVSTGASQGPWPGSFYAVPLGAALGVLAVLVLAALLAVARRPRPALESLGLDSMLRRWSVGNILTAATFTVLGTLGPVATLVALTLSDRQCPATTAEVVVRWVTLVAGPLALVGGAAALGALLVTPTIRVDDLPRPLPGEAAPVGAPVR
>NZ_CP049935.1|WP_166124413.1|3155065_3155755_+|ATP-dependent-dethiobiotin-synthetase-BioD
MPSVVLVTGTGTGVGKTVVTAALAALVRGRGSVAAVVKPTQTGVLADEPGDVDEVRRLVGDDLSVHELVRLRDPLSPEAAARREGVALPPVAVHARRIGELASAADVTIVEGAGGLLVRLDGRGGTLADLGTALRYKGISCGVVLVASAGLGVLSTAALTAEALSARGIPLLGVVVGSWPADPGLAETENLHDLPRVTGAPLWGRVPEGAGSLAAADFAAAVPGWFDIT
>NZ_CP049935.1|WP_166123190.1|3155865_3156381_+|low-molecular-weight-phosphotyrosine-protein-phosphatase
MSAADRPYRVTVVCHGNICRSPMAQFLLREALDEAGLGERVVVDSAGTSAEELGNTVHPRTVGVLRRHGHPDLGWGEHRARQFRPDWFDDTDLVLAADHPHADRLSRLARDEDDAAKVHLVRSFDPEAVAAGELGMDDPWYGGDAEYEQTYDEIRAAVPGIVEHVRAALDG
>NZ_CP049935.1|WP_166124414.1|3157967_3158354_+|GNAT-family-N-acetyltransferase
MEPTAPACSRHALSVEQFRDPVVRLWVAEADPLLVGSVALKDLGGGHLELKTMRTSPSVRGSGLGRRLLLHALAEARAVGATRVSLETGSGAVFEPARTLYRSHGFVDCEPFADYRPDPHSTFLTLAL
>NZ_CP049935.1|WP_166123191.1|3158422_3159175_+|hypothetical-protein
MGRVSDTGSGRAVAVAAACAVLLLGACSGGSGDPAPRRSAPSTSSSASASPSASPSPTPKPGRVDTRAFFDDLEAAVAGQDTADVHLESPYEGIYAEIQTSTASMRVQYQDADRWLRVVVIGDRAWTLDENATDAPWKKVTHAPDDIRKAVPAHLVREWRAGARSVTRGSTETVEGHRITSYTVVLSAERAYGAIGLEAPRKGPSTVRLLVRLDERGLPTEASAALDKGKLEIEYRSWGAALEIVAPPVG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP049935_6	6.1\|2467854\|25\|NZ_CP049935\|PILER-CR	2467854-2467878	25	NZ_CP007130	Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence	191676-191700	3	0.88
NZ_CP049935_6	6.2\|2467923\|25\|NZ_CP049935\|PILER-CR	2467923-2467947	25	NZ_CP007130	Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence	191676-191700	3	0.88
NZ_CP049935_6	6.1\|2467854\|25\|NZ_CP049935\|PILER-CR	2467854-2467878	25	NZ_CP023065	Sinorhizobium sp. CCBAU 05631 plasmid pSS05631a, complete sequence	302278-302302	4	0.84
NZ_CP049935_6	6.1\|2467854\|25\|NZ_CP049935\|PILER-CR	2467854-2467878	25	NZ_CP023065	Sinorhizobium sp. CCBAU 05631 plasmid pSS05631a, complete sequence	304838-304862	4	0.84
NZ_CP049935_6	6.1\|2467854\|25\|NZ_CP049935\|PILER-CR	2467854-2467878	25	NZ_AP022339	Mameliella alba strain KU6B plasmid pKUB112, complete sequence	53061-53085	4	0.84
NZ_CP049935_6	6.1\|2467854\|25\|NZ_CP049935\|PILER-CR	2467854-2467878	25	NZ_AP018921	Pseudonocardia autotrophica strain NBRC 12743 plasmid pPA12743CP, complete sequence	17527-17551	4	0.84
NZ_CP049935_6	6.2\|2467923\|25\|NZ_CP049935\|PILER-CR	2467923-2467947	25	NZ_CP023065	Sinorhizobium sp. CCBAU 05631 plasmid pSS05631a, complete sequence	302278-302302	4	0.84
NZ_CP049935_6	6.2\|2467923\|25\|NZ_CP049935\|PILER-CR	2467923-2467947	25	NZ_CP023065	Sinorhizobium sp. CCBAU 05631 plasmid pSS05631a, complete sequence	304838-304862	4	0.84
NZ_CP049935_6	6.2\|2467923\|25\|NZ_CP049935\|PILER-CR	2467923-2467947	25	NZ_AP022339	Mameliella alba strain KU6B plasmid pKUB112, complete sequence	53061-53085	4	0.84
NZ_CP049935_6	6.2\|2467923\|25\|NZ_CP049935\|PILER-CR	2467923-2467947	25	NZ_AP018921	Pseudonocardia autotrophica strain NBRC 12743 plasmid pPA12743CP, complete sequence	17527-17551	4	0.84

1. spacer 6.1|2467854|25|NZ_CP049935|PILER-CR matches to NZ_CP007130 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence) position: , mismatch: 3, identity: 0.88

ccgtcggcctcactgcgttcggcct	CRISPR spacer
gcgtcggcctcgctgcgttcggcgt	Protospacer
 **********.*********** *

2. spacer 6.2|2467923|25|NZ_CP049935|PILER-CR matches to NZ_CP007130 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence) position: , mismatch: 3, identity: 0.88

ccgtcggcctcactgcgttcggcct	CRISPR spacer
gcgtcggcctcgctgcgttcggcgt	Protospacer
 **********.*********** *

3. spacer 6.1|2467854|25|NZ_CP049935|PILER-CR matches to NZ_CP023065 (Sinorhizobium sp. CCBAU 05631 plasmid pSS05631a, complete sequence) position: , mismatch: 4, identity: 0.84

ccgtcggcctcactgcgttcggcct	CRISPR spacer
ctgtcggcctcaatgcgttcggcaa	Protospacer
*.********** **********

4. spacer 6.1|2467854|25|NZ_CP049935|PILER-CR matches to NZ_CP023065 (Sinorhizobium sp. CCBAU 05631 plasmid pSS05631a, complete sequence) position: , mismatch: 4, identity: 0.84

ccgtcggcctcactgcgttcggcct	CRISPR spacer
ctgtcggcctcaatgcgttcggcaa	Protospacer
*.********** **********

5. spacer 6.1|2467854|25|NZ_CP049935|PILER-CR matches to NZ_AP022339 (Mameliella alba strain KU6B plasmid pKUB112, complete sequence) position: , mismatch: 4, identity: 0.84

ccgtcggcctcactgcgttcggcct	CRISPR spacer
atgtcggccttgctgcgttcggcct	Protospacer
 .********..*************

6. spacer 6.1|2467854|25|NZ_CP049935|PILER-CR matches to NZ_AP018921 (Pseudonocardia autotrophica strain NBRC 12743 plasmid pPA12743CP, complete sequence) position: , mismatch: 4, identity: 0.84

ccgtcggcctcactgcgttcggcct	CRISPR spacer
ccgtcggcctcgctgcgttcgactg	Protospacer
***********.*********.*.

7. spacer 6.2|2467923|25|NZ_CP049935|PILER-CR matches to NZ_CP023065 (Sinorhizobium sp. CCBAU 05631 plasmid pSS05631a, complete sequence) position: , mismatch: 4, identity: 0.84

ccgtcggcctcactgcgttcggcct	CRISPR spacer
ctgtcggcctcaatgcgttcggcaa	Protospacer
*.********** **********

8. spacer 6.2|2467923|25|NZ_CP049935|PILER-CR matches to NZ_CP023065 (Sinorhizobium sp. CCBAU 05631 plasmid pSS05631a, complete sequence) position: , mismatch: 4, identity: 0.84

ccgtcggcctcactgcgttcggcct	CRISPR spacer
ctgtcggcctcaatgcgttcggcaa	Protospacer
*.********** **********

9. spacer 6.2|2467923|25|NZ_CP049935|PILER-CR matches to NZ_AP022339 (Mameliella alba strain KU6B plasmid pKUB112, complete sequence) position: , mismatch: 4, identity: 0.84

ccgtcggcctcactgcgttcggcct	CRISPR spacer
atgtcggccttgctgcgttcggcct	Protospacer
 .********..*************

10. spacer 6.2|2467923|25|NZ_CP049935|PILER-CR matches to NZ_AP018921 (Pseudonocardia autotrophica strain NBRC 12743 plasmid pPA12743CP, complete sequence) position: , mismatch: 4, identity: 0.84

ccgtcggcctcactgcgttcggcct	CRISPR spacer
ccgtcggcctcgctgcgttcgactg	Protospacer
***********.*********.*.

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage