CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP046920	Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence	3 crisprs	c2c4_V-U1	1	10	0	0
NZ_CP046919	Streptococcus sp. CNU G2 chromosome, complete genome	1 crisprs	cas2,cas1,cas9,DinG,csa3,DEDDh,cas3,csm6	3	7	10	2

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP046920_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046920_1

402-701

Orphan

Consensus_repeat	Method
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	CRT
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	PILER-CR
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	CRISPRCasFinder

4 spacers

The CRISPR arrays of NZ_CP046920_1

>merge|NZ_CP046920|1|402-701|CRT,PILER-CR,CRISPRCasFinder
CCTAAGGTGTTTTCTAAACTAGGCTAGTGCCAAAACATTTTTTAATTGACAGTTCTGTTTTTAAGACTTTTGGAACCATGTCAAATAGACTAGTGCCAAAACGCAATATAGTTAACTATGTTGTTATTCCTTCTTTTGGAACCATGTCAAATAGACTAGTGCCAAAACTGCTTTATCTGTGACTGTTTTAGTTGGTTTCTTTTGGAACCATGTCAAATAGACTAGTGCCAAAACACAACCGTTGGACAAATTCTAAAAGGCAATCTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC

>NZ_CP046920|1|1|402-701|CRT
CCTAAGGTGTTTTCTAAACTAGGCTAGTGCCAAAAC	ATTTTTTAATTGACAGTTCTGTTTTTAAGA
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	GCAATATAGTTAACTATGTTGTTATTCCTT
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	TGCTTTATCTGTGACTGTTTTAGTTGGTTT
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	ACAACCGTTGGACAAATTCTAAAAGGCAAT
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC

>NZ_CP046920|1|1|468-701|PILER-CR
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	GCAATATAGTTAACTATGTTGTTATTCCTT
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	TGCTTTATCTGTGACTGTTTTAGTTGGTTT
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	ACAACCGTTGGACAAATTCTAAAAGGCAAT
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC

>NZ_CP046920|1|1|468-701|CRISPRCasFinder
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	GCAATATAGTTAACTATGTTGTTATTCCTT
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	TGCTTTATCTGTGACTGTTTTAGTTGGTTT
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	ACAACCGTTGGACAAATTCTAAAAGGCAAT
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046920.1\|WP_157328569.1\|9525_10776_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328698.1\|903_1596_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328563.1\|4046_5312_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328564.1\|5800_6052_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328571.1\|11511_12327_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|224113
NZ_CP046920.1\|WP_157328702.1\|2737_3235_-\|DUF1768-domain-containing-protein	unknown	unknown	gnl\|CDD\|271319
NZ_CP046920.1\|WP_157328566.1\|6115_8962_-\|TraM-recognition-domain-containing-protein	unknown	unknown	gnl\|CDD\|238547
NZ_CP046920.1\|WP_157328568.1\|8974_9448_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328704.1\|3224_3971_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328700.1\|1603_2179_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239245

Protein	Function_ID	Function_description	E-value
NZ_CP046920.1\|WP_157328571.1\|11511_12327_+\|AAA-family-ATPase	gnl\|CDD\|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	1.39174e-21
NZ_CP046920.1\|WP_157328702.1\|2737_3235_-\|DUF1768-domain-containing-protein	gnl\|CDD\|271319	cd15457, NADAR, Escherichia coli swarming motility protein YbiA and related proteins. This family of uncharacterized domains was initially classified as Domain of Unknown Function (DUF1768). It contains members such as the E. coli swarming motility protein YbiA. Mutations in YbiA cause defects in Escherichia coli swarming, but not necessarily in motility. More recently, this family has been predicted to be involved in NAD-utilizing pathways, likely to act on ADP-ribose derivatives, and has been named the NADAR (NAD and ADP-ribose) superfamily.	6.61717e-09
NZ_CP046920.1\|WP_157328566.1\|6115_8962_-\|TraM-recognition-domain-containing-protein	gnl\|CDD\|238547	cd01127, TrwB, Bacterial conjugation protein TrwB, ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component of Type IV secretion and is responsible for the horizontal transfer of DNA between bacteria.	0.00873175
NZ_CP046920.1\|WP_157328700.1\|1603_2179_-\|hypothetical-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	3.11491e-05

>NZ_CP046920.1|WP_157328698.1|903_1596_-|hypothetical-protein
MDINLIQLLATLVFALLLSAIQSAINIYKLRPLVFETEFNINTTFILMIKVCDVLLLFMAFFAIYNVISDRESIKYTIQALAIIIPRIYFRKKAEGQRYLLIKIDNFFTQRRVKQFKACPCCSDSRLFYRKVLNSDEVCYFLVNKYNTLVYLGFYLNSRDLALPFLNEPFYKALSIVYPLLKESYSDVTVLNDKYYQLDSSLYCAHCHKEVSTYPIELGMVDFKRKNKAK
>NZ_CP046920.1|WP_157328700.1|1603_2179_-|hypothetical-protein
MALSLLIITFNGMKQFSKNSLGLILIFLLSSSSLLWGFIYPTKVSENTFSNTAVTTIFNKQEMKQRFVAGEASALDLSLLKSRTERDWDPIYIFYRTGCSYCHQSIPRLLNQLSEEQKHRIIFLDLDKGNNGKFAAEFGIYHAPTAVISTKGVGGYKNYNISKLVKVSGDSATIDNDTIKHVVSATTLTIR
>NZ_CP046920.1|WP_157328702.1|2737_3235_-|DUF1768-domain-containing-protein
MSTKETYGRIDSGQYYFWGGPLSLGWCYPFDWKEKHFKCAWQALAYEKSLALNPSLSDNILKDNFSEHARDFYFKMDTNDNIMSWQKEKEEVVAIEILNLISVQHPHFAEQLLDTDPLELIYCGAEDYLSIGLPYWHKSANHMDNWRGDNKYGKWLMSVRENLKK
>NZ_CP046920.1|WP_157328704.1|3224_3971_-|hypothetical-protein
MLHLILDIITSFIFLFLYVGTALYLKSRTKTLMFFRHQRVVVNLLVILMIAIIIVNHFLAIGGVVLIPSTTTFTFFVKQIVYDILPISILLLPYQSNPYILTFDNKTRTKIVFERFNFRRNMEISPLLYSYQFPITSENSVADYIYIDVYFVDGYFHALTYIKDTSESTTSASVAIACYSKKASLDILKNMEFSSYNNVDSYNLKETIEAEVFKLDTWINEVVVSKVIASKELKQVFYLLEKGDTNVN
>NZ_CP046920.1|WP_157328563.1|4046_5312_-|hypothetical-protein
MNENIFFNVSSIDENIKLTPPQDSIAYYPISQQKMQYIFFNKKQLLLMYHLLRFSYFDREIIKNIYHSLEPNRILQSSWLQSCIGNRSYPISIYPEFKDGRKKIYYLNKKFAKWLLDTLTLPKFSEFYEMAKSTEYDFSLYSIKSNNLYGGKPRTVNIHDLKTRRLCASIAKEISQRLSGISFESLNIQYSFPTNRKVITLLPDAVIFINGVPFYIEYDRNTELHFQLLGKVIGYFTESYYKNGTVFFVFDELGKPLRNEFHRRVKTFLSKVETTFYQDTNKTYYDMLEENNVTLVANPAEFSVSQIAHHIIKTFYEEHIPKLTIDKVSGLGGLPFEILEITENHNSFFHYEVKVMDDSYEESLIPVLEVSYITAGFALQLEQIYQEYNAQYKHVALRFDRAINAQFYPLPHQNFFIPIFI
>NZ_CP046920.1|WP_157328564.1|5800_6052_+|hypothetical-protein
MAAKKLKLSDYDTDIAKLLKEIEKKKNEKKEYEGKLKSEIGNLYYELLNLEENINLEELRDKLKNQLKQKKAFIKEQKNNNQN
>NZ_CP046920.1|WP_157328566.1|6115_8962_-|TraM-recognition-domain-containing-protein
MKYFLNRLQYYTKGHRTFDFVLLFCKRILQLNFGISILGLLTSLWCLVFKIKVTFGMYMLFWVIQFINLNSALYFGKWHTNLTSRQRFRLFERLSDYPRNERVISIKNYILVSFIGGIISGVNIILFTINNYILATVNSLYLNANSYLKYTDWKLNYHTLHILIGNQFSNSLLLVFPVFIYVYLFLNSYQKDIRPYQLLIDQWLESRFYKDKCIDKLVQDRDTKGISTIKIGVDSKSRTDVIMNAATRALNSVWIGLIGVGKSASIAKPIIISDTENFIFYIKTFAKYVKSKRREIANLDASEEEKRDLNESAVEEWFTKGLGKDLTNGYYVNEPSGDLIKDALEIVKRSGLPDDVVWLVDPHRKDTDAINILDADITTASALASDLFRNFSEGESSSGNTFFLNSEEAHTKNIVNLLKLTTPIAEAPINSHLKGNPPTLSEFFQLLENDDYIFARLELLKVVIKRANRLFEPFNKEFNEKYDSEFEEWISNGNPPSRFNANMSINLRKMSYRHRQEKAKLSIMTDTYTYFKKNLITDFKNESTFKFDANIDGLKNVLRRLAANPEVRRVFFSQSTKSVDALLKMGGILLVNSAKAELGDSNSKMVGQVAEIIMQSGAYRRLPNLSPIFPFMNDEKNTILMKRDQSFLDQNRKFRTPVIHLYQDYEQAVATVGRDRANALFQSYRNAFVFQQGSPDSVKYIANRGGTKLVLEESNRYAQEDLLAGNDSNATNVTETIVEKEMLTQSDMSKLEKFEYAGVMVIDDEVSDVMFITSEPSFKLPMFNKNLDYKPPFDTNNSEDMEAYKIWKEEVEKYYIKNSEREILSEKDFLPDEWLTIMSVQNPDIFEDNKSSFDDENDNIIDDKIAESGSQLKRQREAKEDLKNSKINLQEEVANDSFIEEKISLPKVKVSTRLLNNEEYVIQNEKSETVSQNQLTDFDDEDERIDFY
>NZ_CP046920.1|WP_157328568.1|8974_9448_-|hypothetical-protein
MGLEELNHLMYYFLVALTFLPWLVVIIGLMSLLFAKQIRNNKSRKALTITTGVAIIFVYLLRFIPLFIFAGLYNKNNFNTIKFTDFENIFTLLQFLIVAFIPSFVIIQSHIFNYQKIFTDNRKRSSANNQRIYLIAGAIATFGSLIILQIFKNLFSY
>NZ_CP046920.1|WP_157328569.1|9525_10776_-|hypothetical-protein
MLPLREIQEQYKHAKYLETDDGKKNTSIVIAQARKNQKNWYEEEYMDLGFEVVPSHLISLVQDYTQPHIDRSLMGDERLKREARKKILACRVVGVIETAPTVAKDNPKFVALEDMLVVEPIEPTLEGLKIYVPHRHAGMSQTHKLRHMIDRILPVKLVDLKERRYENYFLENSIKHNYVAEGDIDIAEFIMNSYIADNIPSGNTQRKLTPLQNRILNQPFKGLVTYVSDKGVFVLTNELYTFFIPNEEYSYMANSKVYSIKDTVHTFDEVEFNYTGFRRGRGKNTNSENENTNNTILLQGEHISFEEKPVIRLKRLIEEKKMVGKVFKAYLITYDPTKKHFIELEDFPGVLVKLKPQAEITPQLAVTKEPISVFVERARAYTDTESGKISIFVHCLFNTTINERKNDMLASFFQKK
>NZ_CP046920.1|WP_157328571.1|11511_12327_+|AAA-family-ATPase
MKIITFNNNAGGVGKTTWTFNTAFYAAAEGKRVLVMGTDPSCNLTNRMIGYFARITNQNKEDLLQQIQFENTVEAVFKNVSFAPITITDKIDFLAETKTLYDLKHIKEASLLHWWWDNEEYLMSNYDLILIDTHNDDRVFTKAAYAVSDVVSVLVDKTDKTFDKVSDLREMLEKIKDDNRDRNGTFVTAKIVIIGNDLDNNSAGKAMKLRLEKLQRQYPEDFIGYIEHRESVVKAENAFMPLIEYKNKERLSASLERFYRETKKVIQKLIA

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Crispr_ID: NZ_CP046920_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046920_2

65450-65816

TypeV-U1

Consensus_repeat	Method
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	CRT
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	PILER-CR
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	CRISPRCasFinder

5 spacers

The CRISPR arrays of NZ_CP046920_2

>merge|NZ_CP046920|2|65450-65816|CRT,PILER-CR,CRISPRCasFinder
CCTAAGGTGTTTTCTAAACTGGACTAGTGCCAAAACGAACAAGACGATAAAAGATAAGGCAGTGCTCTTTTGGAACCATGTCAAATAGACTAGTGCCAAAACTACCGTTAATTGTTCTTTTTTTCTGAACAACTTTTGGAACCATGTCAAATAGACTAGTGCCAAAACCTTCTTGCGCCTTGAGAATTTTATATTGAACTTTTGGAACCATGTCAAATAGACTAGTGCCAAAACTTATCGGTTGAAATTCATGATGCACCTTTAACTTTTGGAACCATGTCAAATAGACTAGTGCCAAAACAGCAAACTAGTAATTTCAGTATGTCGATAACTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC

>NZ_CP046920|2|2|65450-65816|CRT
CCTAAGGTGTTTTCTAAACTGGACTAGTGCCAAAAC	GAACAAGACGATAAAAGATAAGGCAGTGCT
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	TACCGTTAATTGTTCTTTTTTTCTGAACAA
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	CTTCTTGCGCCTTGAGAATTTTATATTGAA
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	TTATCGGTTGAAATTCATGATGCACCTTTAA
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	AGCAAACTAGTAATTTCAGTATGTCGATAA
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC

>NZ_CP046920|2|2|65516-65816|PILER-CR
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	TACCGTTAATTGTTCTTTTTTTCTGAACAA
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	CTTCTTGCGCCTTGAGAATTTTATATTGAA
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	TTATCGGTTGAAATTCATGATGCACCTTTAA
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	AGCAAACTAGTAATTTCAGTATGTCGATAA
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC

>NZ_CP046920|2|2|65516-65816|CRISPRCasFinder
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	TACCGTTAATTGTTCTTTTTTTCTGAACAA
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	CTTCTTGCGCCTTGAGAATTTTATATTGAA
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	TTATCGGTTGAAATTCATGATGCACCTTTAA
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC	AGCAAACTAGTAATTTCAGTATGTCGATAA
CTTTTGGAACCATGTCAAATAGACTAGTGCCAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046920.1\|WP_157328626.1\|54403_54763_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328655.1\|69680_69824_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328649.1\|68085_68307_-\|translation-repressor-RelB	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328645.1\|66737_67316_-\|GTP-pyrophosphokinase	unknown	unknown	gnl\|CDD\|143389
NZ_CP046920.1\|WP_157328662.1\|70481_70721_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328653.1\|69131_69614_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328644.1\|64977_65337_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328647.1\|67812_68085_-\|type-II-toxin-antitoxin-system-mRNA-interferase-toxin,-RelE/StbE-family	unknown	unknown	gnl\|CDD\|224937
NZ_CP046920.1\|WP_166044399.1\|68383_68929_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_166044395.1\|58943_61517_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|282904
NZ_CP046920.1\|WP_157328658.1\|69858_70230_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_166044397.1\|67381_67678_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376243
NZ_CP046920.1\|WP_157328660.1\|70260_70485_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328642.1\|63100_64978_-\|AAA-domain-containing-protein	unknown	unknown	gnl\|CDD\|223616
NZ_CP046920.1\|WP_157328632.1\|57453_58188_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328640.1\|62704_63031_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368210
NZ_CP046920.1\|WP_157328630.1\|55465_57439_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328638.1\|61532_62684_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319758
NZ_CP046920.1\|WP_157328634.1\|58364_58898_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328628.1\|54765_55443_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP046920.1\|WP_157328647.1\|67812_68085_-\|type-II-toxin-antitoxin-system-mRNA-interferase-toxin,-RelE/StbE-family	gnl\|CDD\|224937	COG2026, RelE, Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning].	1.18558e-24
NZ_CP046920.1\|WP_157328642.1\|63100_64978_-\|AAA-domain-containing-protein	gnl\|CDD\|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	2.10075e-172
NZ_CP046920.1\|WP_157328640.1\|62704_63031_-\|hypothetical-protein	gnl\|CDD\|368210	pfam04956, TrbC, TrbC/VIRB2 family. Conjugal transfer protein, TrbC has been identified as a subunit of the pilus precursor in bacteria. The protein undergoes three processing steps before gaining its mature cyclic structure. This family also contains several VIRB2 type IV secretion proteins. The virB2 gene encodes a putative type IV secretion system and is known to be a pathogenicity factor in Bartonella species.	5.23938e-05
NZ_CP046920.1\|WP_157328645.1\|66737_67316_-\|GTP-pyrophosphokinase	gnl\|CDD\|143389	cd05399, NT_Rel-Spo_like, Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases. This family includes the catalytic domains of Escherichia coli ppGpp synthetase (RelA), ppGpp synthetase/hydrolase (SpoT), and related proteins. RelA synthesizes (p)ppGpp in response to amino-acid starvation and in association with ribosomes. (p)ppGpp triggers the bacterial stringent response. SpoT catalyzes (p)ppGpp synthesis under carbon limitation in a ribosome-independent manner. It also catalyzes (p)ppGpp degradation. Gram-negative bacteria have two enzymes involved in (p)ppGpp metabolism while most Gram-positive organisms have a single Rel-Spo enzyme (Rel), which both synthesizes and degrades (p)ppGpp. The Arabidopsis thaliana Rel-Spo proteins, At-RSH1,-2, and-3 appear to regulate a rapid (p)ppGpp-mediated response to pathogens and other stresses. This catalytic domain is found in association with an N-terminal HD domain and a C-terminal metal dependent phosphohydrolase domain (TGS). Some Rel-Spo proteins also have a C-terminal regulatory ACT domain. This subgroup belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition.Two of the three catalytic carboxylates are found in Rel-Spo enzymes, with the second carboxylate of the DXD motif missing. Evidence supports a single-cation synthetase mechanism.	0.000160749
NZ_CP046920.1\|WP_157328638.1\|61532_62684_-\|hypothetical-protein	gnl\|CDD\|319758	cd16427, TraM-like, C-terminal domain of transfer protein TraM. This family contains the C-terminal domain of transfer protein TraM of the G+ broad host range Enterococcus conjugative plasmid pIP501 and similar proteins. The protein localizes to the cell envelope and is part of the plasmid transfer system that is accessible from outside of the cell. TraM displays a fold similar to the type IV secretion system (T4SS) VirB8 proteins from A. tumefaciens and B. suis (G-) and to the transfer protein TcpC from C. perfringens plasmid pCW3 (G+), reinforcing the prediction that TraM performs a key role in the secretion process, which is underlined by its surface accessibility. It is also structurally related to members of the nuclear transport factor-2 (NTF-2)-like superfamily with a high similarity to the NTF-2 protein from Rattus norvegicus. TraM (categorized as T4SS VirB8-like class GAMMA) does not possess the binding pocket of classic VirB8 class ALPHA proteins, recognized by VirB8 interaction inhibitors.	2.16561e-26
NZ_CP046920.1\|WP_166044395.1\|58943_61517_-\|hypothetical-protein	gnl\|CDD\|282904	pfam05109, Herpes_BLLF1, Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.	1.5797e-05
NZ_CP046920.1\|WP_166044397.1\|67381_67678_-\|hypothetical-protein	gnl\|CDD\|376243	pfam18824, LPD11, Large polyvalent protein-associated domain 11. This is an alpha-helical domain with conserved hydrophobic residues. It is found in polyvalent proteins of conjugative elements.	3.05773e-26

>NZ_CP046920.1|WP_157328644.1|64977_65337_-|hypothetical-protein
MDKQDNHNYSFSIPRGVYRELKYYGVPVMKAGVIVVTFLLGLQLSGTVFPTDQFFQFVLNDILMTILAFYLVLPTKAGGSNFRAIAYFHIKRKKRYFSIERGGYPVKQEEIKRRRRGKY
>NZ_CP046920.1|WP_157328642.1|63100_64978_-|AAA-domain-containing-protein
MEKIVNSLYKTPALDKFTVDLTEKVRQNPTKYVAYGRNREIERMVTSLLRVDKNSPCLVGEAGVGKTAIVEGFCAACLSNKVPEELQGVRVRSLLLSAIMEKGDPSALLANLYQIIEELTQTNDTNILFIDEVHTIMGTGASEKSALDAGNALKAALSRGEIKLISATTEDEFRIIEKDPAMERRMQSILVEEPDRESALYIMKKIAPRYEKLRGVTITPEALEATVDLSIRYIADKHLPDKAIDLIDEAVAHAYIKNKKTVTFKDIAWLIHLKRGIPLESILLISRGKPIDIEAELAKVVKGQSLAIKTISHKIYSKKTDMQNENRPASAFVLGTTGVGKTELGKQVARLFYGDSEAFIRIDCTEYNSKDSVQRLIGNPANNEKGQLTEQVKNRPYSLIMFDEIEKADPSVHNLLLQILDDGHLTDAYGRKIDFKQSFIYGTSNAGHQTIRDKFAISGDFSNLDSQSYKSFVANVTRDLEQIFRPEFLNRWSSMIIMNLLTEDITLEIISSKLSVLEQQWKEKQHLTIEYKDEDGYENKEDFYDYLKNVGTSVINGARPLERAITDILSDPIAKQLYFFNRRENDSFVVEVVLKGLPPRSYKDGSGRTNIADMRHVDIKVKKLP
>NZ_CP046920.1|WP_157328640.1|62704_63031_-|hypothetical-protein
MKFKDVKNTAKAKWLLATAMVNSAIISSPVLADNPWGKVQSATTNFTEKVRNLSFFVFIATVVVAGLMFAFGDIGKNKAMKWLPYIVGGVALVSGATSLIMWLKEIFG
>NZ_CP046920.1|WP_157328638.1|61532_62684_-|hypothetical-protein
MVNNFGFTGTKGVKIEDPLFIYVEWDDNYKPSNTPQLRDLIENLDLEHFSNSEYTISNSLPFLTFKQAEILFRGLRDKFEYFWFKGIALATQVNDNGKLTGKASIENSPQVVPFEIYAKYDNLVIPIIEATFRDERFQNYSYDELARYFCDVNYNLMDCYGKSLGLSRSEFPYFPLAGTIEGELPRKSAVKEQVTPKRTAQINPKAKSNGKVRVEDLEHNNKDVIFKVTAIIALLLSVFLVVFTVMLTNKTISQEKKLEYLYSKTTEIQDLQTHEHSADTFGKFFLAYYFAGNRDELDQFLSDGDAKYTQPETGTVSSLTLNDFTKDDDEYTLSYVVTYRDENDTLNTKTFTFNCIPKEKSQWHWLVTSEPIIEDYIDSDENN
>NZ_CP046920.1|WP_166044395.1|58943_61517_-|hypothetical-protein
MAFDTRLNGEGTFWKNIKSMGENLSDQAFDLNHNFKINDTDSQVLSTFYKQWSEYLTPHPHFFTTFLTIPEWFAKTFYGFSNALESIFNKIFALFGFFSLLGSNDNFIGQIYSGLRTVGISLFIAFIVVRVVIGIIGTPFKYKEFFNHAILVTAATAFLPAALTSFSEVVADSSKDLQTYVASGTKQGSTLSAQPFQDNVVDIMQLARVGFNASKLGRQRGDDGYINPSKAEANGVRLNRLSSKNIASTNFVTSYGPNDKEELEHFADAAKNKSKFLFFEIPTGDNENSMYYCLATLFRSELRKNDWDDSGQKPVEVEVAGYKVTSIVGYNILKPVYLRYKVNWIGLFVEQAMLILLLIGLLITVLQTIMRTLLSSVVAPIVGYTSVDNSAKFLDLLRTIFAGIAGIWFDILIVKYGLWFISKAPTMAFSSHNNNFGSFIGNLGFWGNTIATIALYIAVFYATIQGSRAIENWLGVSTGAKAGIAQTAATVGAGVMAGRAIEQASIGRKDINGNRHGGSIGHEMRNIRNAAQRGTKGVKDFGGSVLKNTAAEMGALYGSGSALRDNYNKRGGGLKGATFGTLDTLRNGAQIPASKFQSKGNAGVNALKDAYSSGKASAYSNFTSPSSRNIAESSITPEELASVLPTNSVNLETPEELAGGSSAKLAEDVSTKGVTSTSKEAVAPSKTVSTKGVTSTSKEAVAPSKTVSTKGVTSTSKEAVAPSKTVSTKGVTSTPREVVAPSKTVSTKGVTSTPKEVVAPSKTVSTKGVTSTPREVVAPSKTVSTKGVTSTPREVVAPSKTVSTKSVTSTPQKTVTKQRINSPHIGNEKISQENYEVNRPKVAKRLSGFGKEEDSSL
>NZ_CP046920.1|WP_157328634.1|58364_58898_+|hypothetical-protein
MTNYLINFWELYEKHFITMPLNAFIYFLVWQIIVIVIGSILLSIHPFLGKLVMIVLSILGGGYGAYITYKKAPNNFKSYETPRFLIIIHFGLFLTTGILLLILGNITLLIIEFFINIFLLFEYIFKQVYTVVSNFTQEDWSCTFVILILLFLFSGIGSGPLSLVTFISAKKSFKNKK
>NZ_CP046920.1|WP_157328632.1|57453_58188_-|hypothetical-protein
MGITEALKLENKLFKNKKESSDLPSDSPKMVKLNLKDNIVDFKFNYDKEWEDKDFLDVVEIMSVKSILYSVRNQPIVLSNGYSGYMQILEVYGKDLSSLSDYERTMAIVSFTQWLAGTTFDVTFQTTTLPTDTKQQITELARVLEEVEYALLNPKLSSQQKFRLNQRRDILRQNIITEEVVAMQQYNTEFFVWIFADTLEELADYTRTAQSISYGFQPHVVDAKKKEQILTQFYNYNDSQLSFR
>NZ_CP046920.1|WP_157328630.1|55465_57439_-|hypothetical-protein
MWLSKRKIKKYLNKGYDLNLLGRIEPTGNVNFGENDAYWKQGDGYYKLDHIPNDGYPQSGLRKFWLQDIMLAHGVNSFVAVEHGSNSKLSDQTTKAISNMLHTQNRKQTDDVDDKSKIQSLLDFRAALGNNVPVKEIRTSFYISGDSEEKLREKERHLKSKLNQFKIVSNDGMQDVEYGTAFIPASRQGHLPTRRHGQPISVVDLGAGYPFNHTTLMDTRGVYVGQTLTGGAVNFNLLQEDDIRSIPTMLIAGRDRTDKDKFLAKQLDVLFAKGHQEFNIDLNGILGDLTRRQGGKIIEMSGIDNDNYLNLMEVIATRSMKNSLNEDDQIGSFQDHREKLKAFAQIKNPELSVSDLNNLGFAIDELYTERGLWSAKAQSMKPSELLITKARQSDYPILANLVELLNSMRRQKESNNEIEEAHSYRRLFDAFYNLLQENRDLNRTSNFEDLSEESVVTFDLSGIADTTLLNIQLYQILSLISYYAVLNGKRNQRIVEEGTDLEKDQLPHCIVTITGAERLFNRRYSKSLEFLARMIENISSNYAAVILEMSSLQDILISSNDTSGNDYVLATRKVFSATRYRLFSQLDELTIPLLSNALGGELTESELETLKYLPRGRFFLNIASVRNLIFEQQLSSSDDIDIWGMVYSEIDRYSSLR
>NZ_CP046920.1|WP_157328628.1|54765_55443_-|hypothetical-protein
MAFLMRFSGVVNAFLYDIKTLKIYHILSIMLSIALGCGALLAYVMHYYSMMINFGKQSIIVFYMPYVIFGILYSLFQLLKRQKQLLVLGLVICFLPSTLTSEFGITADIFWGMSYFVYFLDKRHLQNIVRIVAMYSKKYSPLYEKRLKNKVKYKQYQSDYRLLALLNVDDFNLISEEIRQVKNYKTGLSERTMYRTFKIKGILGKISIVDELYTMPRKHFWIKGI
>NZ_CP046920.1|WP_157328626.1|54403_54763_-|hypothetical-protein
MKQSEFYDDEWNAQEYYEKLFENLKQENLERTVADEYSSLNLRKKGIIKRTKELYQESIDDISQYYEDNVNLQKKYYSNADSHWLTRQQEYRNKIYFKKFIMVLLFMIILSLFIYLLTI
>NZ_CP046920.1|WP_157328645.1|66737_67316_-|GTP-pyrophosphokinase
MFLNNIQKVERLISEINRIHLEYSKDYFETGKVEKVNLKHTFSKVPTKEILKYRLNLHESINDYLMSADLDDIAYYYRVKTSESILDKIERFSKRQEGYPVNSILNDIFGARMILSSAEIAEVMEKLDDWQVKFGLKNWYLKDTADYTGIHIYFKNGSNFFYPWELQLWDKKDVKRNVEGHIKYKRNFVNDL
>NZ_CP046920.1|WP_166044397.1|67381_67678_-|hypothetical-protein
MSESTINVTEKINTFKKDIIQHYPKNDSFLYRLLSRMQYDCNYYLGNGERCEKYLWGETVELHLAYMELLWDNFSSTEKPEWLTKEELEDYKRKMILK
>NZ_CP046920.1|WP_157328647.1|67812_68085_-|type-II-toxin-antitoxin-system-mRNA-interferase-toxin,-RelE/StbE-family
MYHVEYSKRAKKQIKKLDKSVQRLLFAWIDKNLEGCDNPRQHGKGLTANRANQWRYRIGNYRLICDIQDDKAVILALEFGHRSTIYVRGE
>NZ_CP046920.1|WP_157328649.1|68085_68307_-|translation-repressor-RelB
MSTITVRLNQKEEELFKGYSELSGESISTLLKKALINNIEDELDYKVYQEAYQEYQKDSETISHADFKKELGL
>NZ_CP046920.1|WP_166044399.1|68383_68929_-|hypothetical-protein
MNKKMISLKLDISELNGMKIEAPYYTYEAAIPTFKINDTWQAIIDDESQKVIFEEDVAIYLPLVAKRVPEEELDYTLEFTSYDEMKDVFDIEAPLEGNATLKITVKKGNSFSISDLDRENLSNVDDIKFAYELSHSFDHDYWHVGTQNNSLDDLLFTVDDLKEVQYFDLVKKLHIIKDEHI
>NZ_CP046920.1|WP_157328653.1|69131_69614_-|hypothetical-protein
MTITLTQKQYKVMKKEIVRNSATLVGFNYAIFEKCDHIMLLKAIDEVARSDFYLGLSEADKENFLITKIVKYSSYQDFKKLAPYFFSFSRFARANKEKLLNTILEDDEASKGGVAFAGETLTDFLNEIGKAESIPYMYSDEWLEEVNIMLGECGIKTLSL
>NZ_CP046920.1|WP_157328655.1|69680_69824_-|hypothetical-protein
MVTNNEKAKEILSSRYKDKANLLPPFLNLDGEYCIYRYNELFAIVRK
>NZ_CP046920.1|WP_157328658.1|69858_70230_-|hypothetical-protein
MINVVYNNYSTLAPSSGAYRGAYRWYKKFHNAGYDVRIRKLEENDLKVFSELEIDIRSQVNSHSLCWLIIYDDKQKRKYITNESREISFEDVVGLFRTRQERRVEMQEILARLHATCSLASSK
>NZ_CP046920.1|WP_157328660.1|70260_70485_-|hypothetical-protein
MIHTFIDSKAVVEIPNEDIECVLAGAMKKCFGYRTPTRYYSTWLARFEGLNYNAYQTILLELVKLGYGRILKNK
>NZ_CP046920.1|WP_157328662.1|70481_70721_-|hypothetical-protein
MEILKLTTRQENIVEYRKKLESMFFNDQETYFKAIISFETGIKDIKQLDRIFELWLKGSTNLFSENLLRICEEIRGELA

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Crispr_ID: NZ_CP046920_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046920_3

79651-79753

Orphan

Consensus_repeat	Method
GTTTTGGCACTAGTCTGTTTGACATGGTTCCAAAAGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046920_3

>merge|NZ_CP046920|3|79651-79753|CRISPRCasFinder
GTTTTGGCACTAGTCTGTTTGACATGGTTCCAAAAGTAAAAATAATTTACGGGGGGTGTCAAAAGAGTTTTGGCACTAGTCTGTTTGACATGGTTCCAAAAGT

>NZ_CP046920|3|3|79651-79753|CRISPRCasFinder
GTTTTGGCACTAGTCTGTTTGACATGGTTCCAAAAGT	AAAAATAATTTACGGGGGGTGTCAAAAGA
GTTTTGGCACTAGTCTGTTTGACATGGTTCCAAAAGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046920.1\|WP_157328671.1\|72390_72726_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328679.1\|78154_78670_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328683.1\|79253_79394_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328673.1\|72797_73757_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377346
NZ_CP046920.1\|WP_157328715.1\|77402_78143_-\|sortase	unknown	unknown	gnl\|CDD\|320680
NZ_CP046920.1\|WP_157328692.1\|84038_84836_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328669.1\|71646_72336_-\|DNA-repair-protein-RadC	unknown	unknown	gnl\|CDD\|178801
NZ_CP046920.1\|WP_157328677.1\|75132_76692_-\|DnaD-domain-protein	unknown	unknown	gnl\|CDD\|226445
NZ_CP046920.1\|WP_157328686.1\|81244_81580_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328685.1\|79930_81001_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328690.1\|82620_83673_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328667.1\|71412_71610_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328688.1\|81673_82426_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328681.1\|78741_79011_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046920.1\|WP_157328694.1\|84930_85569_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369151
NZ_CP046920.1\|WP_157328675.1\|74035_74479_-\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|180915

Protein	Function_ID	Function_description	E-value
NZ_CP046920.1\|WP_157328673.1\|72797_73757_-\|hypothetical-protein	gnl\|CDD\|377346	pfam04404, ERF, ERF superfamily. The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to ERF.	1.04499e-11
NZ_CP046920.1\|WP_157328715.1\|77402_78143_-\|sortase	gnl\|CDD\|320680	cd06165, Sortase_A, Sortase domain found in class A sortases. Class A sortases are membrane-bound cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Firmicutes). They perform a housekeeping role in the cell as members of this group are capable of anchoring a large number of functionally distinct surface proteins containing a cell wall sorting signal to an amino group located on the bacterial cell wall. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is cleaved at a conserved cell wall-sorting signal (Class A sortases recognize a canonical LPXTG motif, X can be any amino acid), and covalently linked to peptidoglycan for display on the bacterial surface. The prototypical sortase A protein from Staphylococcus aureus (named Sa-SrtA) cleaves the amide bond between threonine and glycine residues of the canonical LPXTG motif in a wide range of protein substrates with diverse functions that can promote bacterial adhesion, nutrient acquisition, host cell invasion, and immune evasion. Next, it catalyzes a transpeptidation reaction by which the proteins are covalently linked to the peptidoglycan precursor lipid II. SrtA is therefore affects the ability of a pathogen to establish successful infection. SrtA contains an N-terminal hydrophobic segment, a linker region and an extra-cellular C-terminal catalytic domain. The hydrophobic segment functions as both a signal peptide for secretion and a stop-transfer signal for membrane anchoring. The catalytic domain contains the catalytic TLXTC signature sequence where X is usually a valine, isoleucine or a threonine. The gene encoding SrtA is generally not located in the same gene cluster as its substrates while the gene encoding SrtB is usually clustered in the same locus as its substrate.	2.419e-57
NZ_CP046920.1\|WP_157328669.1\|71646_72336_-\|DNA-repair-protein-RadC	gnl\|CDD\|178801	PRK00024, PRK00024, DNA repair protein RadC.	2.38169e-65
NZ_CP046920.1\|WP_157328677.1\|75132_76692_-\|DnaD-domain-protein	gnl\|CDD\|226445	COG3935, DnaD, Putative primosome component and related proteins [DNA replication, recombination, and repair].	8.39529e-08
NZ_CP046920.1\|WP_157328694.1\|84930_85569_-\|hypothetical-protein	gnl\|CDD\|369151	pfam06970, RepA_N, Replication initiator protein A (RepA) N-terminus. This of family of predicted proteins represents the N-terminus (approximately 80 residues) of replication initiator protein A (RepA), a DNA replication initiator in plasmids. Most proteins in this family are bacterial, but archaeal and eukaryotic members are also included.	1.13212e-09
NZ_CP046920.1\|WP_157328675.1\|74035_74479_-\|single-stranded-DNA-binding-protein	gnl\|CDD\|180915	PRK07275, PRK07275, single-stranded DNA-binding protein; Provisional.	4.49516e-38

>NZ_CP046920.1|WP_157328683.1|79253_79394_-|hypothetical-protein
MEASKTSILDIINLMSTLNADTVEMDFEYDGTPLRFQCKLMLREDD
>NZ_CP046920.1|WP_157328681.1|78741_79011_-|hypothetical-protein
MKKCLNFSINHKQLEELLENGEVVITSSELPYDDKKLHIFIEDPFVEHNTTNYLIVSQAALRILKKEKSFPLYMRLGSELIEGKMILEN
>NZ_CP046920.1|WP_157328679.1|78154_78670_-|hypothetical-protein
MILLNRYFGQWLDQNKSDDYYETITKAYDVMSSSIYLGFRHPELEQSFEEALISNSYAYAVPKEISVNEINPNNYYRYEVQQPNYIGNEKLSFYGKGNFILEHYKYFDHELYQDNEIHLTIYEYLNYNDMMLDLKEECYVLHKTVFSVAKNHSISPIYWNDDTQQLAVAQN
>NZ_CP046920.1|WP_157328715.1|77402_78143_-|sortase
MIRVKSKFRSYVRGVVIILFLVIGFSLILNKEIRNLLIAQNSNKYQVTNVDKATLKKNQKANTSFDFSAVDSATSESILANQFDNRKLPVIGGIAIPELNINLPIFKGLGNAELSYGAGTMKEKQVMGGKNNYALASHHVFGINGSSGMLFSPLDNARNGMKIYITDKEKVFTYIVSSIEVVDPDQSEVIQDISDRRTITLVTCYDEAATKRLIVSGTFHKSTLYKEVDGTVRKAFERKYNQMYNN
>NZ_CP046920.1|WP_157328677.1|75132_76692_-|DnaD-domain-protein
MVQEEVSVMVSYPEQESKFRNKIQYSREFPALFDLGDLNKVEENITFSILGELTDRYSTGDIEFTYSEIAHMAGLVSVDSNNNTFAQTGARFNKIIEALQNKLQTVSYKKLKSLDNAGEVDEYEVYPLFKKYKVSHREQKLTVVLSDEVYQEEFIEVDSDGNTIVHPEKRVYELFNQDNWSQIKYLKFGREIHNLLKSKYSKRLYRFLSEYRNYGSCYKLADEFENDIMKLNTPSLKKNKRKKIGEAFEELKKLSDQEGNAIIPNLDMKVEKRGRSTYKYYFTFSRFSNDLNEVISHNKNNLILKLLPMAKVSDDTNIEEYQEILEVFHDVFGTDRQVDNNPNRKKIKEWLNLINSDVIKEIIIRTGYKNNRGFGWTVKVIQNLIDAGVVTLDDLKEYETQRYNKGAVIVKQLIASNSDYETLFSNLKNMLKKDVSLLILEDIQKYAEKVEVNVISSAIKIAIFNTKDNWTYVKGILDNWIKAGITTQQQIDNEEQAKTQPLEISDDFLDAMDLWSEDY
>NZ_CP046920.1|WP_157328675.1|74035_74479_-|single-stranded-DNA-binding-protein
MNNVNLIGRTTRDVELRYTPNNTPVASVNIAVNRRFKNKETGERQTDFFPLVIWGKSAENFAKWIKKGYLISVEGELRSRNYENNQGQHVYVVEVLVSHFDNLTPRSQQNEENQVVDQQNTSTFDSFAELSSLDDTLADFATDDLPF
>NZ_CP046920.1|WP_157328673.1|72797_73757_-|hypothetical-protein
MENTELTQGMMTTEVLVNRLIAAEVALEKQKLAEKQDKSAKMGELYRDFAKAQSEFLIPSNNATVEVFPKNGKRGYSFKFATLPEILKATVPALNAHNIAFSQHSKYAPAANGMYITVVTELLHESGAKLSYESVPMLYNAENAQNMGAVESYLCRYGAKRILGIDADDDNDGNFTLKNDHKEAFSNHKTYRQQALKQDDTPEVVKGQKEQGFTFIRNEQNHSDDKENVLSGSQTEAEMQSPTQPNTIADNKSISSSEQKTKEVPNSEELMEKAQKILEEGLLRAEECGATDEQLSTWANPTNIQETIREIATFVRSHQ
>NZ_CP046920.1|WP_157328671.1|72390_72726_-|hypothetical-protein
MESVIITKFEAKIGEVIFQQENLFYSVQYIVNAIEDKFGDCFQESFVEALRDEIETIYLKYDNFSWSVLENSFYLAIEEAPTFNAIVFNYNGCDWKLEWLNEEIRTGAYNI
>NZ_CP046920.1|WP_157328669.1|71646_72336_-|DNA-repair-protein-RadC
METSYTITNNHEKSLNVCETVLNTEYTVDALSETELLAAFLQMSESDQEAFNKARNILDRVEVSRINSLGYGSLVKDYGLSEQQATSFLSALELFKRSSKANSTTQRIMSSERIANQLMIEIGDKKQEHLMVLYLDTQNRVIDKRIVFIGSVNRSIATPREILYYACQNMATSIIVAHNHPSGSINPSENDNIFTQKLEKACGTIEVTLLDHIIVTFNNYTSYREEGLL
>NZ_CP046920.1|WP_157328667.1|71412_71610_-|hypothetical-protein
MDYVTQQTLWYAFLSEGPLKLVVFLIGIMMMKSILRNKKVFRIFAFLVLVIPLSVLEVVGLFIKK
>NZ_CP046920.1|WP_157328685.1|79930_81001_+|hypothetical-protein
MESNEFYDEKTKLEIFGEKVEQFFTKNKLVDLLRRKVLLRKTLVFYSLLIPIIVLICGGLFSPQRQTYTDDQLATKREFENDTGTVLLKSQEYSESNDIMVLNFETEDATSSIDKGINANNLDWTLYTPPGLDASKTEMDVIPLTGNKVSVVIKNVPKNYGALGIDIANSTASDADVDVSLKNYDDYIKEQEENVSVDGTDSSDNDDKKKSNTVSFLISPQSGQIKNKKIKNLSREKFALTIFNEEMKFQKGQKDKLITAAKRIKANIAEDNDTIEQLERESQYLVGPELETKQDEIEDVRNDIDNKQKDVTTATENIVTVNSIITNLKKSIAKVKDGSYEFNAPIKSVRKDLSQE
>NZ_CP046920.1|WP_157328686.1|81244_81580_-|hypothetical-protein
MSERKLESYDVLVLSKCLYNKLHISLTAKEFSKYLSGATPTKEHLQLLARLFRVNEFWLLGFDVNQEYISTSEQSEVIVNELLGAVKSLENTLSQLPSQGLLDRDNTAKMI
>NZ_CP046920.1|WP_157328688.1|81673_82426_-|hypothetical-protein
MEPLQLLVLKDNEKNSTPLTLLPEQISSVIFTGEYFHFAMKGSNAINIYMASDYRNPRQLRGINYSLITIDRKKEIEDYLTRIFPHCYLQFGSIGWCWDKQQIPENSYLVQNKQKNNYLDVDTEHLLLSEKADTYINVLSGSTFYLIQPYLKNQAIICSVSYNNIGEFTKTLRTVQHFYCTTDSGAKKEADNTKSGSKNEYLLVGPLNDKAYAAYWEQRIFDRSNTEKNIQTIRKNVFVLPIKQGLLNIY
>NZ_CP046920.1|WP_157328690.1|82620_83673_-|hypothetical-protein
MKRKNQLRKEANFKTYKSPEDFEDFLQRRIDYLMDLPPHQKSYDYFLGTVLKGFYFRTILKSQDNKSQPKSRLLLSEYKDKYIHCRGIIGGIRRFKRYDPLTKKKTYQADKLLIINPCLNFEVCRTVNTQDNTITLSRKTPNMIFRMIDTHIWVDLKDCYPMDPNQTNFQLAIGLDIQFVAKVNEYRGKVTHDVRGKQIKYGLENVIITSAGYQTYKEIKHSKKNDVDVLKSVLEYDSLGFEVTKDQFGDKEEVADKLVETKQFNLKEFCVVFWDRNRQQFVRNKSWAGKWYFEIENLPDETTQDDYNQIFERLSCDFLFKHDTVVKKSFKRFKEILSEELLAHFLIDEP
>NZ_CP046920.1|WP_157328692.1|84038_84836_-|hypothetical-protein
MSNKKNNFIKVGFFILIFSFLLLLLDIINLPTKLGFNLKVLNFEIWGIYATFLGSGLTLYGVILTINSQYEAQLEDTKRIVKPMLDISASEYDYRHKNIDFSFPKDFPHLPRKDNVDTPSITISLENVGNRELYNLCLGNFESLTFNENGHYYKLSPILYPHHKETLNFCFYEKIGYLNEFNREDKFDLFTSPIKFTAYFQDCLDTWYSQEFQIGIFNQIQKNKSDEETSLEVNIERTNVVSAPKEISNNSLPWGDKQDIWVYYF
>NZ_CP046920.1|WP_157328694.1|84930_85569_-|hypothetical-protein
MNYLTSIHDIPEFATANLDSDQIYIPTPIINQLMGDLKSKGALAYSVLLNRLREPLDFIHKGYDEAGNTFIYFTNKELGEVLNCNKDSVISTKKILHQLNLIDEVQQGFGEPNRIYITDNILKYYSNTQLPKYIKEKYLRINKLREQALDLEAEIDEWFTKKDLETLTYDSKGNFLPLLSGDGRNFYQSEDEALMALDEAYRQLLIEHAHDS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP046920_1	1.1\|438\|30\|NZ_CP046920\|CRT	438-467	30	NZ_CP046920.1	79753-79782	0	1.0

1. spacer 1.1|438|30|NZ_CP046920|CRT matches to position: 79753-79782, mismatch: 0, identity: 1.0

attttttaattgacagttctgtttttaaga	CRISPR spacer
attttttaattgacagttctgtttttaaga	Protospacer
******************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP046920_1	1.1\|438\|30\|NZ_CP046920\|CRT	438-467	30	NZ_CP046630	Streptococcus equinus strain CNU G6 plasmid p1_CNU_G6, complete sequence	75974-76003	0	1.0
NZ_CP046920_1	1.1\|438\|30\|NZ_CP046920\|CRT	438-467	30	NZ_CP046630	Streptococcus equinus strain CNU G6 plasmid p1_CNU_G6, complete sequence	83118-83147	0	1.0
NZ_CP046920_1	1.1\|438\|30\|NZ_CP046920\|CRT	438-467	30	NZ_CP046920	Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence	79753-79782	0	1.0
NZ_CP046920_1	1.1\|438\|30\|NZ_CP046920\|CRT	438-467	30	NZ_CP046920	Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence	438-467	0	1.0
NZ_CP046920_1	1.2\|504\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	504-533	30	NZ_CP046630	Streptococcus equinus strain CNU G6 plasmid p1_CNU_G6, complete sequence	83184-83213	0	1.0
NZ_CP046920_1	1.2\|504\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	504-533	30	NZ_CP046920	Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence	504-533	0	1.0
NZ_CP046920_1	1.2\|504\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	504-533	30	NC_015219	Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069 plasmid pSGG1, complete sequence	15154-15183	0	1.0
NZ_CP046920_1	1.3\|570\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	570-599	30	NZ_CP046630	Streptococcus equinus strain CNU G6 plasmid p1_CNU_G6, complete sequence	83250-83279	0	1.0
NZ_CP046920_1	1.3\|570\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	570-599	30	NZ_CP046625	Streptococcus sp. CNU G3 plasmid p1_CUN_G3, complete sequence	26184-26213	0	1.0
NZ_CP046920_1	1.3\|570\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	570-599	30	NZ_CP046920	Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence	570-599	0	1.0
NZ_CP046920_1	1.4\|636\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	636-665	30	NZ_CP046630	Streptococcus equinus strain CNU G6 plasmid p1_CNU_G6, complete sequence	83316-83345	0	1.0
NZ_CP046920_1	1.4\|636\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	636-665	30	NZ_CP046920	Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence	636-665	0	1.0
NZ_CP046920_2	2.1\|65486\|30\|NZ_CP046920\|CRT	65486-65515	30	NZ_CP046630	Streptococcus equinus strain CNU G6 plasmid p1_CNU_G6, complete sequence	61840-61869	0	1.0
NZ_CP046920_2	2.1\|65486\|30\|NZ_CP046920\|CRT	65486-65515	30	NZ_CP046920	Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence	65486-65515	0	1.0
NZ_CP046920_2	2.2\|65552\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	65552-65581	30	NZ_CP046920	Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence	65552-65581	0	1.0
NZ_CP046920_2	2.3\|65618\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	65618-65647	30	NZ_CP046630	Streptococcus equinus strain CNU G6 plasmid p1_CNU_G6, complete sequence	61906-61935	0	1.0
NZ_CP046920_2	2.3\|65618\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	65618-65647	30	NZ_CP046920	Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence	65618-65647	0	1.0
NZ_CP046920_2	2.4\|65684\|31\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	65684-65714	31	NZ_CP046920	Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence	65684-65714	0	1.0
NZ_CP046920_2	2.5\|65751\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	65751-65780	30	NZ_CP046920	Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence	65751-65780	0	1.0
NZ_CP046920_3	3.1\|79688\|29\|NZ_CP046920\|CRISPRCasFinder	79688-79716	29	NZ_CP046630	Streptococcus equinus strain CNU G6 plasmid p1_CNU_G6, complete sequence	75909-75937	0	1.0
NZ_CP046920_3	3.1\|79688\|29\|NZ_CP046920\|CRISPRCasFinder	79688-79716	29	NZ_CP046625	Streptococcus sp. CNU G3 plasmid p1_CUN_G3, complete sequence	34965-34993	0	1.0
NZ_CP046920_3	3.1\|79688\|29\|NZ_CP046920\|CRISPRCasFinder	79688-79716	29	NZ_CP046920	Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence	79688-79716	0	1.0
NZ_CP046920_2	2.4\|65684\|31\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	65684-65714	31	NZ_CP046625	Streptococcus sp. CNU G3 plasmid p1_CUN_G3, complete sequence	34398-34428	3	0.903
NZ_CP046920_2	2.3\|65618\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	65618-65647	30	CP017837	Proteobacteria phage MWH-Nonnen-W8red 2 genome	32184-32213	5	0.833
NZ_CP046920_2	2.2\|65552\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	65552-65581	30	NZ_CP021438	Bacillus thuringiensis strain C15 plasmid pBMB172, complete sequence	24049-24078	6	0.8
NZ_CP046920_2	2.2\|65552\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	65552-65581	30	MN693746	Marine virus AFVG_250M731, complete genome	26049-26078	6	0.8
NZ_CP046920_2	2.3\|65618\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	65618-65647	30	NZ_CP017256	Clostridium taeniosporum strain 1/k plasmid pCt3, complete sequence	7236-7265	6	0.8
NZ_CP046920_1	1.3\|570\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	570-599	30	MK448389	Streptococcus satellite phage Javan260, complete genome	10300-10329	7	0.767
NZ_CP046920_2	2.1\|65486\|30\|NZ_CP046920\|CRT	65486-65515	30	LC494302	Escherichia phage SP27 DNA, complete genome	276945-276974	7	0.767
NZ_CP046920_2	2.1\|65486\|30\|NZ_CP046920\|CRT	65486-65515	30	LT603033	Escherichia phage vB_Eco_slurp01 genome assembly, chromosome: I	218457-218486	7	0.767
NZ_CP046920_2	2.1\|65486\|30\|NZ_CP046920\|CRT	65486-65515	30	KM507819	Escherichia phage 121Q, complete genome	277594-277623	7	0.767
NZ_CP046920_2	2.1\|65486\|30\|NZ_CP046920\|CRT	65486-65515	30	MK817115	Escherichia phage vB_EcoM_phAPEC6, complete genome	199593-199622	7	0.767
NZ_CP046920_2	2.1\|65486\|30\|NZ_CP046920\|CRT	65486-65515	30	NC_027364	Escherichia phage PBECO 4, complete genome	8041-8070	7	0.767
NZ_CP046920_2	2.1\|65486\|30\|NZ_CP046920\|CRT	65486-65515	30	MH383160	Escherichia phage UB, complete genome	68629-68658	7	0.767
NZ_CP046920_2	2.1\|65486\|30\|NZ_CP046920\|CRT	65486-65515	30	MK327931	Escherichia phage vB_EcoM_G17, complete genome	224887-224916	7	0.767
NZ_CP046920_2	2.4\|65684\|31\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	65684-65714	31	HQ632860	Vibrio phage jenny 12G5 genomic sequence	29843-29873	7	0.774
NZ_CP046920_2	2.2\|65552\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	65552-65581	30	JN638751	Bacillus phage G, complete genome	111846-111875	8	0.733
NZ_CP046920_1	1.2\|504\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	504-533	30	NZ_CP041930	Klebsiella pneumoniae strain 18-2374 plasmid pSECR18-2374C, complete sequence	7181-7210	9	0.7
NZ_CP046920_1	1.2\|504\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	504-533	30	NZ_CP043383	Enterobacter hormaechei subsp. xiangfangensis strain WCHEX045001 plasmid pNDM1_045001, complete sequence	74053-74082	9	0.7
NZ_CP046920_1	1.2\|504\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	504-533	30	NZ_CP049048	Enterobacter hormaechei strain Y233 plasmid p233-142, complete sequence	27213-27242	9	0.7
NZ_CP046920_2	2.2\|65552\|30\|NZ_CP046920\|CRT,PILER-CR,CRISPRCasFinder	65552-65581	30	NZ_CP045274	Bacillus megaterium strain FDU301 plasmid pFDU301B, complete sequence	73850-73879	9	0.7

1. spacer 1.1|438|30|NZ_CP046920|CRT matches to NZ_CP046630 (Streptococcus equinus strain CNU G6 plasmid p1_CNU_G6, complete sequence) position: , mismatch: 0, identity: 1.0

attttttaattgacagttctgtttttaaga	CRISPR spacer
attttttaattgacagttctgtttttaaga	Protospacer
******************************

2. spacer 1.1|438|30|NZ_CP046920|CRT matches to NZ_CP046630 (Streptococcus equinus strain CNU G6 plasmid p1_CNU_G6, complete sequence) position: , mismatch: 0, identity: 1.0

attttttaattgacagttctgtttttaaga	CRISPR spacer
attttttaattgacagttctgtttttaaga	Protospacer
******************************

3. spacer 1.1|438|30|NZ_CP046920|CRT matches to NZ_CP046920 (Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence) position: , mismatch: 0, identity: 1.0

attttttaattgacagttctgtttttaaga	CRISPR spacer
attttttaattgacagttctgtttttaaga	Protospacer
******************************

4. spacer 1.1|438|30|NZ_CP046920|CRT matches to NZ_CP046920 (Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence) position: , mismatch: 0, identity: 1.0

attttttaattgacagttctgtttttaaga	CRISPR spacer
attttttaattgacagttctgtttttaaga	Protospacer
******************************

5. spacer 1.2|504|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP046630 (Streptococcus equinus strain CNU G6 plasmid p1_CNU_G6, complete sequence) position: , mismatch: 0, identity: 1.0

gcaatatagttaactatgttgttattcctt	CRISPR spacer
gcaatatagttaactatgttgttattcctt	Protospacer
******************************

6. spacer 1.2|504|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP046920 (Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence) position: , mismatch: 0, identity: 1.0

gcaatatagttaactatgttgttattcctt	CRISPR spacer
gcaatatagttaactatgttgttattcctt	Protospacer
******************************

7. spacer 1.2|504|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to NC_015219 (Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069 plasmid pSGG1, complete sequence) position: , mismatch: 0, identity: 1.0

gcaatatagttaactatgttgttattcctt	CRISPR spacer
gcaatatagttaactatgttgttattcctt	Protospacer
******************************

8. spacer 1.3|570|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP046630 (Streptococcus equinus strain CNU G6 plasmid p1_CNU_G6, complete sequence) position: , mismatch: 0, identity: 1.0

tgctttatctgtgactgttttagttggttt	CRISPR spacer
tgctttatctgtgactgttttagttggttt	Protospacer
******************************

9. spacer 1.3|570|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP046625 (Streptococcus sp. CNU G3 plasmid p1_CUN_G3, complete sequence) position: , mismatch: 0, identity: 1.0

tgctttatctgtgactgttttagttggttt	CRISPR spacer
tgctttatctgtgactgttttagttggttt	Protospacer
******************************

10. spacer 1.3|570|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP046920 (Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence) position: , mismatch: 0, identity: 1.0

tgctttatctgtgactgttttagttggttt	CRISPR spacer
tgctttatctgtgactgttttagttggttt	Protospacer
******************************

11. spacer 1.4|636|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP046630 (Streptococcus equinus strain CNU G6 plasmid p1_CNU_G6, complete sequence) position: , mismatch: 0, identity: 1.0

acaaccgttggacaaattctaaaaggcaat	CRISPR spacer
acaaccgttggacaaattctaaaaggcaat	Protospacer
******************************

12. spacer 1.4|636|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP046920 (Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence) position: , mismatch: 0, identity: 1.0

acaaccgttggacaaattctaaaaggcaat	CRISPR spacer
acaaccgttggacaaattctaaaaggcaat	Protospacer
******************************

13. spacer 2.1|65486|30|NZ_CP046920|CRT matches to NZ_CP046630 (Streptococcus equinus strain CNU G6 plasmid p1_CNU_G6, complete sequence) position: , mismatch: 0, identity: 1.0

gaacaagacgataaaagataaggcagtgct	CRISPR spacer
gaacaagacgataaaagataaggcagtgct	Protospacer
******************************

14. spacer 2.1|65486|30|NZ_CP046920|CRT matches to NZ_CP046920 (Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence) position: , mismatch: 0, identity: 1.0

gaacaagacgataaaagataaggcagtgct	CRISPR spacer
gaacaagacgataaaagataaggcagtgct	Protospacer
******************************

15. spacer 2.2|65552|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP046920 (Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence) position: , mismatch: 0, identity: 1.0

taccgttaattgttctttttttctgaacaa	CRISPR spacer
taccgttaattgttctttttttctgaacaa	Protospacer
******************************

16. spacer 2.3|65618|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP046630 (Streptococcus equinus strain CNU G6 plasmid p1_CNU_G6, complete sequence) position: , mismatch: 0, identity: 1.0

cttcttgcgccttgagaattttatattgaa	CRISPR spacer
cttcttgcgccttgagaattttatattgaa	Protospacer
******************************

17. spacer 2.3|65618|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP046920 (Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence) position: , mismatch: 0, identity: 1.0

cttcttgcgccttgagaattttatattgaa	CRISPR spacer
cttcttgcgccttgagaattttatattgaa	Protospacer
******************************

18. spacer 2.4|65684|31|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP046920 (Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence) position: , mismatch: 0, identity: 1.0

ttatcggttgaaattcatgatgcacctttaa	CRISPR spacer
ttatcggttgaaattcatgatgcacctttaa	Protospacer
*******************************

19. spacer 2.5|65751|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP046920 (Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence) position: , mismatch: 0, identity: 1.0

agcaaactagtaatttcagtatgtcgataa	CRISPR spacer
agcaaactagtaatttcagtatgtcgataa	Protospacer
******************************

20. spacer 3.1|79688|29|NZ_CP046920|CRISPRCasFinder matches to NZ_CP046630 (Streptococcus equinus strain CNU G6 plasmid p1_CNU_G6, complete sequence) position: , mismatch: 0, identity: 1.0

aaaaataatttacggggggtgtcaaaaga	CRISPR spacer
aaaaataatttacggggggtgtcaaaaga	Protospacer
*****************************

21. spacer 3.1|79688|29|NZ_CP046920|CRISPRCasFinder matches to NZ_CP046625 (Streptococcus sp. CNU G3 plasmid p1_CUN_G3, complete sequence) position: , mismatch: 0, identity: 1.0

aaaaataatttacggggggtgtcaaaaga	CRISPR spacer
aaaaataatttacggggggtgtcaaaaga	Protospacer
*****************************

22. spacer 3.1|79688|29|NZ_CP046920|CRISPRCasFinder matches to NZ_CP046920 (Streptococcus sp. CNU G2 plasmid p_CNU_G2, complete sequence) position: , mismatch: 0, identity: 1.0

aaaaataatttacggggggtgtcaaaaga	CRISPR spacer
aaaaataatttacggggggtgtcaaaaga	Protospacer
*****************************

23. spacer 2.4|65684|31|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP046625 (Streptococcus sp. CNU G3 plasmid p1_CUN_G3, complete sequence) position: , mismatch: 3, identity: 0.903

ttatcggttgaaattcatgatgcacctttaa	CRISPR spacer
ttaccgattgaaattcatgatgcacctttga	Protospacer
***.**.**********************.*

24. spacer 2.3|65618|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to CP017837 (Proteobacteria phage MWH-Nonnen-W8red 2 genome) position: , mismatch: 5, identity: 0.833

cttcttgcgccttgagaattttatattgaa	CRISPR spacer
cttcttgcgctttgagaattttacctgaaa	Protospacer
**********.************. * .**

25. spacer 2.2|65552|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP021438 (Bacillus thuringiensis strain C15 plasmid pBMB172, complete sequence) position: , mismatch: 6, identity: 0.8

taccgttaattgttctttttttctgaacaa	CRISPR spacer
tagatataattgttattattttctgaacaa	Protospacer
**    ******** ** ************

26. spacer 2.2|65552|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to MN693746 (Marine virus AFVG_250M731, complete genome) position: , mismatch: 6, identity: 0.8

taccgttaattgttctttttttctgaacaa	CRISPR spacer
ttcttgtaattgttcttttcttctgaagaa	Protospacer
* *.  *************.******* **

27. spacer 2.3|65618|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP017256 (Clostridium taeniosporum strain 1/k plasmid pCt3, complete sequence) position: , mismatch: 6, identity: 0.8

cttcttgcgccttgagaattttatattgaa	CRISPR spacer
attctatttccttgagaattttttattgaa	Protospacer
 ****  . ************* *******

28. spacer 1.3|570|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to MK448389 (Streptococcus satellite phage Javan260, complete genome) position: , mismatch: 7, identity: 0.767

tgctttatctgtgactgttttagttggttt	CRISPR spacer
ttttaagtctctgactgttttagttgattt	Protospacer
* .*  .*** ***************.***

29. spacer 2.1|65486|30|NZ_CP046920|CRT matches to LC494302 (Escherichia phage SP27 DNA, complete genome) position: , mismatch: 7, identity: 0.767

gaacaagacgataaaagataaggcagtgct	CRISPR spacer
gtgaatcacgataaacgataaggcagtgtt	Protospacer
* . *  ******** ************.*

30. spacer 2.1|65486|30|NZ_CP046920|CRT matches to LT603033 (Escherichia phage vB_Eco_slurp01 genome assembly, chromosome: I) position: , mismatch: 7, identity: 0.767

gaacaagacgataaaagataaggcagtgct	CRISPR spacer
gtgaatcacgataaacgataaggcagtgtt	Protospacer
* . *  ******** ************.*

31. spacer 2.1|65486|30|NZ_CP046920|CRT matches to KM507819 (Escherichia phage 121Q, complete genome) position: , mismatch: 7, identity: 0.767

gaacaagacgataaaagataaggcagtgct	CRISPR spacer
gtgaatcacgataaacgataaggcagtgtt	Protospacer
* . *  ******** ************.*

32. spacer 2.1|65486|30|NZ_CP046920|CRT matches to MK817115 (Escherichia phage vB_EcoM_phAPEC6, complete genome) position: , mismatch: 7, identity: 0.767

gaacaagacgataaaagataaggcagtgct	CRISPR spacer
gtgaatcacgataaacgataaggcagtgtt	Protospacer
* . *  ******** ************.*

33. spacer 2.1|65486|30|NZ_CP046920|CRT matches to NC_027364 (Escherichia phage PBECO 4, complete genome) position: , mismatch: 7, identity: 0.767

gaacaagacgataaaagataaggcagtgct	CRISPR spacer
gtgaatcacgataaacgataaggcagtgtt	Protospacer
* . *  ******** ************.*

34. spacer 2.1|65486|30|NZ_CP046920|CRT matches to MH383160 (Escherichia phage UB, complete genome) position: , mismatch: 7, identity: 0.767

gaacaagacgataaaagataaggcagtgct	CRISPR spacer
gtgaatcacgataaacgataaggcagtgtt	Protospacer
* . *  ******** ************.*

35. spacer 2.1|65486|30|NZ_CP046920|CRT matches to MK327931 (Escherichia phage vB_EcoM_G17, complete genome) position: , mismatch: 7, identity: 0.767

gaacaagacgataaaagataaggcagtgct	CRISPR spacer
gtgaatcacgataaacgataaggcagtgtt	Protospacer
* . *  ******** ************.*

36. spacer 2.4|65684|31|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to HQ632860 (Vibrio phage jenny 12G5 genomic sequence) position: , mismatch: 7, identity: 0.774

ttatcggttgaaattcatgatgcacctttaa	CRISPR spacer
ctatcgattgagattcatgatgcaaagttag	Protospacer
.*****.****.************   ***.

37. spacer 2.2|65552|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to JN638751 (Bacillus phage G, complete genome) position: , mismatch: 8, identity: 0.733

taccgttaattgttctttttttctgaacaa	CRISPR spacer
ttttcttaattgttcttgttttcttaactg	Protospacer
* .. ************ ****** *** .

38. spacer 1.2|504|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP041930 (Klebsiella pneumoniae strain 18-2374 plasmid pSECR18-2374C, complete sequence) position: , mismatch: 9, identity: 0.7

gcaatatagttaactatgttgttattcctt	CRISPR spacer
tttactggattaactatgttgttattcttt	Protospacer
 . *.  ..******************.**

39. spacer 1.2|504|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP043383 (Enterobacter hormaechei subsp. xiangfangensis strain WCHEX045001 plasmid pNDM1_045001, complete sequence) position: , mismatch: 9, identity: 0.7

gcaatatagttaactatgttgttattcctt	CRISPR spacer
tttactggattaactatgttgttattcttt	Protospacer
 . *.  ..******************.**

40. spacer 1.2|504|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP049048 (Enterobacter hormaechei strain Y233 plasmid p233-142, complete sequence) position: , mismatch: 9, identity: 0.7

gcaatatagttaactatgttgttattcctt	CRISPR spacer
tttactggattaactatgttgttattcttt	Protospacer
 . *.  ..******************.**

41. spacer 2.2|65552|30|NZ_CP046920|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP045274 (Bacillus megaterium strain FDU301 plasmid pFDU301B, complete sequence) position: , mismatch: 9, identity: 0.7

taccgttaattgttctttttttctgaacaa	CRISPR spacer
cgtaattaattgctctttttttctgatcgt	Protospacer
... .*******.************* *.

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP046919

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP046919_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046919_1

116033-116793

TypeII

Consensus_repeat	Method
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	CRISPRCasFinder
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	CRT
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	PILER-CR

11 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of NZ_CP046919_1

>merge|NZ_CP046919|1|116033-116793|CRISPRCasFinder,CRT,PILER-CR
GGGTTTTGGTGTTGTAAATCTTGAGAGTACAAAAACTGCTCTTTATCCAACGTATACTTAACTGGGTTTTACGGTTACTTAAATCTTGAGAGTACAAAAACACGTTATATCGAAGAAATTTGCAGGTTTTTGTTTTACGGTTACTTAAATCTTGAGAGTACAAAAACTTGCTAGCTTGATAGTTGGCAAGATTTGTCGTTTTACGGTTACTTAAATCTTGAGAGTACAAAAACTAGCGGACGGTCTGGGTCATTCAACAGCTAGTTTTACGGTTACTTAAATCTTGAGAGTACAAAAACTAGCGGACGGTCTGGGTCATTCAACAGCTAGTTTTACGGTTACTTAAATCTTGAGAGTACAAAAACTCGATTAGGTAGACGTCTTCTTGTGTAGGGGTTTTACGGTTACTTAAATCTTGAGAGTACAAAAACAATCGATGAGGTCGTAATATATGGCGGATTGTTTTACGGTTACTTAAATCTTGAGAGTACAAAAACTAATTCTCGTCATCAAGGTCGAGAATGGCAGTTTTACGGTTACTTAAATCTTGAGAGTACAAAAACCGCCAGAAGACTGTAAGTATGTCATGATTTGTTTTACGGTTACTTAAATCTTGAGAGTACAAAAACTTTGGTGACGCTCATTGCTTACCTCCTTAAGTTTTACGGTTACTTAAATCTTGAGAGTACAAAAACAATGTTTTATTTACATTATAACCAACAGTAGTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC

>NZ_CP046919|1|1|116033-116793|CRISPRCasFinder
GGGTTTTGGTGTTGTAAATCTTGAGAGTACAAAAAC	TGCTCTTTATCCAACGTATACTTAACTGG
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	ACGTTATATCGAAGAAATTTGCAGGTTTTT
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	TTGCTAGCTTGATAGTTGGCAAGATTTGTC
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	TAGCGGACGGTCTGGGTCATTCAACAGCTA
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	TAGCGGACGGTCTGGGTCATTCAACAGCTA
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	TCGATTAGGTAGACGTCTTCTTGTGTAGGG
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	AATCGATGAGGTCGTAATATATGGCGGATT
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	TAATTCTCGTCATCAAGGTCGAGAATGGCA
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	CGCCAGAAGACTGTAAGTATGTCATGATTT
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	TTTGGTGACGCTCATTGCTTACCTCCTTAA
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	AATGTTTTATTTACATTATAACCAACAGTA
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC

>NZ_CP046919|1|1|116033-116793|CRT
GGGTTTTGGTGTTGTAAATCTTGAGAGTACAAAAAC	TGCTCTTTATCCAACGTATACTTAACTGG
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	ACGTTATATCGAAGAAATTTGCAGGTTTTT
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	TTGCTAGCTTGATAGTTGGCAAGATTTGTC
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	TAGCGGACGGTCTGGGTCATTCAACAGCTA
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	TAGCGGACGGTCTGGGTCATTCAACAGCTA
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	TCGATTAGGTAGACGTCTTCTTGTGTAGGG
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	AATCGATGAGGTCGTAATATATGGCGGATT
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	TAATTCTCGTCATCAAGGTCGAGAATGGCA
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	CGCCAGAAGACTGTAAGTATGTCATGATTT
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	TTTGGTGACGCTCATTGCTTACCTCCTTAA
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	AATGTTTTATTTACATTATAACCAACAGTA
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC

>NZ_CP046919|1|1|116098-116793|PILER-CR
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	ACGTTATATCGAAGAAATTTGCAGGTTTTT
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	TTGCTAGCTTGATAGTTGGCAAGATTTGTC
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	TAGCGGACGGTCTGGGTCATTCAACAGCTA
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	TAGCGGACGGTCTGGGTCATTCAACAGCTA
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	TCGATTAGGTAGACGTCTTCTTGTGTAGGG
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	AATCGATGAGGTCGTAATATATGGCGGATT
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	TAATTCTCGTCATCAAGGTCGAGAATGGCA
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	CGCCAGAAGACTGTAAGTATGTCATGATTT
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	TTTGGTGACGCTCATTGCTTACCTCCTTAA
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC	AATGTTTTATTTACATTATAACCAACAGTA
GTTTTACGGTTACTTAAATCTTGAGAGTACAAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046919.1\|WP_004232469.1\|122807_123224_-\|nucleoside-diphosphate-kinase	unknown	unknown	gnl\|CDD\|179085
NZ_CP046919.1\|WP_134775434.1\|123601_123772_-\|NADH-quinone-oxidoreductase-subunit-L	unknown	unknown	unknown
NZ_CP046919.1\|WP_079255235.1\|105421_105487_-\|KxxxW-cyclized-peptide-pheromone	unknown	unknown	unknown
NZ_CP046919.1\|WP_021142653.1\|112082_112559_-\|shikimate-kinase	unknown	unknown	gnl\|CDD\|234654
NZ_CP046919.1\|WP_157629189.1\|125285_126014_-\|acyl-[acyl-carrier-protein]-thioesterase	unknown	unknown	gnl\|CDD\|366738
NZ_CP046919.1\|WP_166042920.1\|123341_123581_-\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	unknown	unknown	gnl\|CDD\|374224
NZ_CP046919.1\|WP_074481524.1\|124417_125191_-\|TIGR01457-family-HAD-type-hydrolase	unknown	unknown	gnl\|CDD\|319832
NZ_CP046919.1\|WP_157629182.1\|112551_113835_-\|3-phosphoshikimate-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|235037
NZ_CP046919.1\|WP_024343822.1\|113968_115804_-\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NZ_CP046919.1\|WP_166042916.1\|118226_119138_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|274694
NZ_CP046919.1\|WP_166042908.1\|107481_107886_-\|HIT-family-protein	unknown	unknown	gnl\|CDD\|238608
NZ_CP046919.1\|WP_166042912.1\|109630_111109_-\|LCP-family-protein	unknown	unknown	gnl\|CDD\|224235
NZ_CP046919.1\|WP_166042914.1\|116855_117905_-\|CRISPR-associated-protein-Cas7	csn2	cd12217_csn2_CAS-II-A	gnl\|CDD\|213410
NZ_CP046919.1\|WP_166042922.1\|123768_124428_-\|TIGR01906-family-membrane-protein	unknown	unknown	gnl\|CDD\|226884
NZ_CP046919.1\|WP_166042905.1\|103718_104810_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP046919.1\|WP_074626518.1\|105567_106431_-\|Rgg/GadR/MutR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|273772
NZ_CP046919.1\|WP_024343825.1\|111261_112086_-\|prephenate-dehydratase	unknown	unknown	gnl\|CDD\|237013
NZ_CP046919.1\|WP_045797755.1\|117901_118225_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NZ_CP046919.1\|WP_166042910.1\|108151_109522_-\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	unknown	unknown	gnl\|CDD\|225174
NZ_CP046919.1\|WP_166042918.1\|119309_122702_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|273840

Protein	Function_ID	Function_description	E-value
NZ_CP046919.1\|WP_004232469.1\|122807_123224_-\|nucleoside-diphosphate-kinase	gnl\|CDD\|179085	PRK00668, ndk, mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated.	5.89419e-80
NZ_CP046919.1\|WP_021142653.1\|112082_112559_-\|shikimate-kinase	gnl\|CDD\|234654	PRK00131, aroK, shikimate kinase; Reviewed.	1.13515e-61
NZ_CP046919.1\|WP_157629189.1\|125285_126014_-\|acyl-[acyl-carrier-protein]-thioesterase	gnl\|CDD\|366738	pfam01643, Acyl-ACP_TE, Acyl-ACP thioesterase. This family consists of various acyl-acyl carrier protein (ACP) thioesterases (TE) these terminate fatty acyl group extension via hydrolysing an acyl group on a fatty acid.	3.80467e-98
NZ_CP046919.1\|WP_024343822.1\|113968_115804_-\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NZ_CP046919.1\|WP_166042920.1\|123341_123581_-\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	gnl\|CDD\|374224	pfam15919, HicB_lk_antitox, HicB_like antitoxin of bacterial toxin-antitoxin system. This is a family of HicB-like antitoxins.	4.6508e-11
NZ_CP046919.1\|WP_074481524.1\|124417_125191_-\|TIGR01457-family-HAD-type-hydrolase	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.45179e-129
NZ_CP046919.1\|WP_157629182.1\|112551_113835_-\|3-phosphoshikimate-1-carboxyvinyltransferase	gnl\|CDD\|235037	PRK02427, PRK02427, 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional.	0
NZ_CP046919.1\|WP_045797755.1\|117901_118225_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	2.10007e-29
NZ_CP046919.1\|WP_166042916.1\|118226_119138_-\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274694	TIGR03639, cas1_NMENI, CRISPR-associated endonuclease Cas1, subtype II/NMENI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.	5.04418e-124
NZ_CP046919.1\|WP_166042908.1\|107481_107886_-\|HIT-family-protein	gnl\|CDD\|238608	cd01277, HINT_subgroup, HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life. Although the biochemical function has not been characterised for many of the members of this subgroup, the proteins from Yeast have been shown to be involved in secretion, peroxisome formation and gene expression.	1.26798e-43
NZ_CP046919.1\|WP_166042912.1\|109630_111109_-\|LCP-family-protein	gnl\|CDD\|224235	COG1316, LytR, Transcriptional regulator [Transcription].	1.72049e-51
NZ_CP046919.1\|WP_166042914.1\|116855_117905_-\|CRISPR-associated-protein-Cas7	gnl\|CDD\|213410	cd12217, Stu0660_Csn2, Stu0660-like CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. This family of Csn2 proteins includes Stu0660, the proteins are larger than other (canonical) Csn2 proteins as they have an additional alpha-helical C-terminal domain. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	9.72134e-143
NZ_CP046919.1\|WP_166042922.1\|123768_124428_-\|TIGR01906-family-membrane-protein	gnl\|CDD\|226884	COG4478, COG4478, Predicted membrane protein [Function unknown].	1.60054e-60
NZ_CP046919.1\|WP_166042905.1\|103718_104810_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.75195e-06
NZ_CP046919.1\|WP_074626518.1\|105567_106431_-\|Rgg/GadR/MutR-family-transcriptional-regulator	gnl\|CDD\|273772	TIGR01716, HTH-type_transcriptional_regulator_rgg, transcriptional activator, Rgg/GadR/MutR family, C-terminal domain. This model describes the whole, except for a 60 residue N-terminal helix-turn-helix DNA-binding domain (pfam01381) of the family of proteins related to the transcriptional regulator Rgg, also called RopB. Rgg is required for secretion of several proteins, including a cysteine proteinase associated with virulence. GadR is a positive regulator of a glutamate-dependent acid resistance mechanism. MutR is a transcriptional activator for mutacin biosynthesis genes in Streptococcus mutans. This family appears restricted to the low-GC Gram-positive bacteria, including at least eight members in Lactococcus lactis. [Regulatory functions, DNA interactions].	8.12369e-40
NZ_CP046919.1\|WP_024343825.1\|111261_112086_-\|prephenate-dehydratase	gnl\|CDD\|237013	PRK11898, PRK11898, prephenate dehydratase; Provisional.	4.17381e-148
NZ_CP046919.1\|WP_166042910.1\|108151_109522_-\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	gnl\|CDD\|225174	COG2265, TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis].	0
NZ_CP046919.1\|WP_166042918.1\|119309_122702_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|273840	TIGR01865, conserved_hypothetical_protein, CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1. CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein found only in CRISPR-containing species, near other CRISPR-associated proteins (cas), as part of the NMENI subtype of CRISPR/Cas locus. The species range so far for this protein is animal pathogens and commensals only.	2.9228e-180

>NZ_CP046919.1|WP_024343822.1|113968_115804_-|elongation-factor-4
MDIQELKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSREMQAQLLDSMDLERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFSYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVRQEIEDVIGLDASEAVLASAKAGIGIEEILEQIVEYVPAPAGDVEAPLQALIFDSVYDAYRGVILQVRIVNGMVKPGDTIQLMSNGKTFDVTEVGIFTPKAVGRDFLATGDVGYIAASIKTVADTRVGDTVTLADNPAEAPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQFEPETSQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVVYHVNTTDGDMLEVSNPSEFPDPTKVASIEEPYVKAQIMVPQEFVGAVMELAQRKRGDFVTMDYIDENRVNVIYQIPLAEIVFDFFDKLKSSTRGYASFDYEISEYRKSKLVKMDILLNGDKVDALSFIVHNEFAYERGKLIVEKLKKIIPRQQFEVPIQAAIGQKIVARSDIKALRKNVLAKCYGGDVSRKRKLLEKQKAGKKRMKAIGSVEVPQEAFLSVLSMDDESSKK
>NZ_CP046919.1|WP_157629182.1|112551_113835_-|3-phosphoshikimate-1-carboxyvinyltransferase
MKLLTNVSQLQGTLRVPGDKSISHRSIMFGSLAKGKTTVRDILRGEDVLSTMQVFRDLGVDIQDDGELVTITGVGFDGLKAPKNKLNMGNSGTSIRLISGVLAGQDFTVEMFGDDSLSKRPMDRVTIPLRQMGVEVSGQTERDLPPLTMHGSKSLKPIHYQLPVASAQVKSALIFAALQADGESVIIEKEKTRNHTEDMIVQFGGKIDVNGKEIRIKGGQEFTGQDVVVPGDISSAAFWLVAGLIVPNAKVTLKNVGINETRTGILDVIKAMGGKMTISDVDDIAKSATITVETSELHGTEIGGEIIPRLIDELPIIALLATQANGTTVIRDAEELKVKETDRIQVVADALNAMGADITPTDDGMIIKGKTPLHGAKINTFGDHRIGMMTAIAALLVSDGDVELERAEAINTSYPSFFSDLEVLSHG
>NZ_CP046919.1|WP_021142653.1|112082_112559_-|shikimate-kinase
MARIIIGFMGSGKSTISSLLDKDYVDMDALITERIGMSIADFFEKEGEAKFREIESQVLAELVNSEHVISTGGGVVINPINRDILAKNGETIYLKADFDTLYDRIKNDTKNVRPLFINNSKEAFKAIFDGRREMYESAANRIIEVAGKTPEEIVEEIG
>NZ_CP046919.1|WP_024343825.1|111261_112086_-|prephenate-dehydratase
MKVGYLGPSGSFTHNVAVKAFPDDERMPFANITEVIKSYEEGVVDYAIIPVENSIEGSVHETLDYLYHQANIEAVAEMIQPIKQQLLATSQDKKIEKIFSHPQAIAQGKKYIKAHYPNAQIEMTASTAYAARYIAENPDEPYAAIAPAAAAKEYGLVIIAKDIQEMDENYTRFWLLGRQKPVFDLPKSQQKLSLAITLQDNLPGALYKALSVFAWRGINLTKIESRPLKTALGEYFFIVDVDNSNEALVVCALEELQLLGIDYKTLGNYDVYKL
>NZ_CP046919.1|WP_166042912.1|109630_111109_-|LCP-family-protein
MAQDKLSRHEELRYEYLLGNLEYLNPQQKEEFGYLYHKKQMSMQEMSSGYPSSANKEPNYERYDDYGDYYEYYDYYDDDYDDDYDAYVTYDEYDDYDDYDNQVTSQGLPKYPKAKKSRPSKRKKKAKKQTSYLDYYEGIAHEEPKVTKAKKPKKKNHKKRFKHFLQFCGFLVVIIMIGMVYMFYHGVHEVSSGETNYSAAVVEPFNGQDSHDGTNILILGSDKRISQGSSDARTDTIMVMNIGNKEGKVKLVSFMRDTLVNINGVSYNDYANDQKLNVAFNIGEQDDRQGAELMRKTLKDNFDINVKYYVMVDFETFAEAINTLFPKGVEIDAKFGTVDGQEVSSVEVPDDLSMQADGSVPNQTIEVGQQRMDGRTLLNYARFRKDDDGDYGRTQRQQQVISAIVNQIKDPSKLFTGSAAIGKIYALTSTNISYPFLVKEGLGVVTSGQKGIEQKTVPAEGDWTDGYDMYGGLGIAIDFNKYQKELKDIGLR
>NZ_CP046919.1|WP_166042910.1|108151_109522_-|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD
MLEKNSIVEVEITDLSHEGAGVAKVDGFVFFVENALPGEKIKMRVLKVKKNIGFGKVEEYLTISEHRNQDLNVDYLRTGIADFGHLAYAEQLKFKRKQVADNLYKTAGISDVEVLETLGMEHPYAYRNKAQVPVRRVNGQLETGFFRKHSHDLMPISDFYIQNKEIDRLINFTRDLLRRFDLKPYDEKEQTGLIRNLVVRRGHYSGEMMLVFVTTRPKIFRIEQIIEKIVAEFPAVKSIVQNINDKNTNAIFGNDFRTLYGKDTIVDSMLGNQYEISARSFYQVNTEMAEKLYQTAIDFSDLTADDIVIDAYSGIGTIGLSFAKNVKAVYGVEVIEEAVEDAKRNAALNGITNAHYVADSAEHAMATWSKNGIKPSVILVDPPRKGLTENFIKASVAMQPEKVTYISCNPATMARDIKLYQELGYKLQKVQPVDLFPNTHHVEAVSLLVRAAETAK
>NZ_CP046919.1|WP_166042908.1|107481_107886_-|HIT-family-protein
MTNCIFCKIISGEISSLKIYEDDLTIAFMDIARDVDGHVLVIPKTHCKNILDCNSTLLNAVMQTVQKLSVHFTENCGYDGVNLLNASDESAGQSVPHFHIHIIPRKNDDGIDAWPKFGGAKQDVQKIYEQLKLL
>NZ_CP046919.1|WP_074626518.1|105567_106431_-|Rgg/GadR/MutR-family-transcriptional-regulator
MKKFGEIFKKFRESRGLRLKDVAKVGISTSQLSRFENGETDLTISKFIAVLDEVNVPIDEFMYAVHDFRRDELNELLLKVNCFVSNHDVEGMKKLLYLQMESNSKRSKFHQINTILLKIRLQDLSGEPYYSSDDLSYLTDYLFSVEYWGYYELLIFANTLDALNHDVFMVLAREMCRRSDFYKEIPKNRRMISSMLLNGYITCVERGKIFDALYFEKQLKQCFFTETEIYERLVFQYVQHLYQYKKEGDRKAIVEMRKSIAAMKLAGSNHIAKIYEGHLEKILADKG
>NZ_CP046919.1|WP_079255235.1|105421_105487_-|KxxxW-cyclized-peptide-pheromone
MSKELEKVLESSSMAKGDGWK
>NZ_CP046919.1|WP_166042905.1|103718_104810_-|MFS-transporter
MSKRIFNLYVMNIFLSGLPYYFVTMLLLKHLGFSFTEIASLSVITELCGSFFDIPLSVISSKFGYKKILVISNFLLILALSCLLFGKSNIIYISAISFGLSESLSSGVLNAYNFEIIDDEVVYKSFLKYLNTIKYVFIAIVTIISPYLLNRNFSYPIIISIVFVVLSQLSLIGLPEIRNTLNNDQKIFSIDNVKDIPWNLILLGVAFSTLIMISNSYAGIFLNEQGLSLDMLGIVLFMFNISMALGSYLKIKFKISLMLPILAIFMFFQTNLFIQIITFLLMRILNSSYNNHFYSKFNMSIEKNRAVSWSVYNLFISISFMVADFLAGIFADNFSIRSNYLIFGTVSLFCLVLFSFSNREKKT
>NZ_CP046919.1|WP_166042914.1|116855_117905_-|CRISPR-associated-protein-Cas7
MKWHFTHPYKDNLDINFGQFTQIIGQNQQLKYYMWHLLMWYFDGKKYSEEDLSLFNQEEPEILSDGKVLKRKDFKVISISDIQDLLEQMSYKKGTVAFDFMKSKLDTIDVMTEVDGINDRLDRISLTVNQNLNLSIDNVTYHTESCLVTSEQLLSKYFQPYFNYQEKNIAFEFVNNETKVMFLLKMIKEKLKNDTGNILLVFKNMDDYLDYSSFIRICESITQITSEFPNFYCTIFPSNESYLYVTKETIESVTIVSDYIESLYDLDFMYERFVGRYPSNNIPTKKEFLILLQKNASYLFSDQITYVSLGISDMVAIKILNSLYQYDKKLSYPIPLVDPLEISFLKDKD
>NZ_CP046919.1|WP_045797755.1|117901_118225_-|CRISPR-associated-endonuclease-Cas2
MRYAAMRLLCFFDLPMETAQEKRTYRNFRKELIANGFEMLQFSVYYRTCPNRSFANKFYKRLQQSNLPAGNVRLLAVTEKQFSEMTLIVGGKTKQEEVVSNNKLVVI
>NZ_CP046919.1|WP_166042916.1|118226_119138_-|type-II-CRISPR-associated-endonuclease-Cas1
MTWRVVHVNQSEKMHLKLDNIVIKKLGEEYTIPLSDISIIVAEGGDTVVTLRLLSALSKFNIALIVCDNEHLPTGIYHAPNGHSRAYKRLQKQLEWSQEQKDKLWQIVTYFKINNQQDVLSLFERDIDAIQLLADYKDHIELGDKTNREGHAAKVYFNELFGKKFTRVTQQEADVINAGLNYGYAILRAQMARIVEGYGLNPLIGIFHRNEYNQFNLVDDLMEPFRQIVDIWVYQNLRDKEYLKYEYRLNLTNLLNANIKYGKENCSVTGAMDKYVQGFIKCIDKKDTSKFFCPVVSSLELES
>NZ_CP046919.1|WP_166042918.1|119309_122702_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MTNGKILGLDIGVASVGVGIIEAKTGKVIHANSRLFSAANAENNAERRGFRGARRLTRRKKHRVKRVRDLFEKYDISTDFRNLNLNPYELRVKGLSEQLTNEELFAALRTIAKRRGISYLDDAEDDSTGSSDYAKSIEENRRLLKNMTPGQIQLERLEKYGQLRGNFTVYDENGEAHRLINVFSTSDYKNEARKILETQSNYNKQITDEFIEDYIEILTQKRKYYHGPGNEKSRTDYGRYRTDGTTLENIFGILIGKCTFYPDEYRTSKASYTAQEYNFLNDLNNLKVPTETGKLSTEQKHYLVDFAKSSKALGVAKLLKEIAKIVECSVDDIKGYREDNKGKPDLHTFEPYRKLKFNLSLIDIDELSRETLDKLADILTLNTEREGIEDAIKRNLPNQFTEEQIVELVNVRKNQSSAFNKGWHSFSVKLMNELIPELYATSEEQMTILTRLEKFKVNKKSSENTKTINEKEITDEIYNPVVAKSVSQTVKIINAAVKKYGDFDKIVIEMPRDKNADDEKKFIDKKQKENAKEVEDALKRAAYLYNGTDKLPDGVFHGNKQLKTKIRLWYQQGERCLYSGKPISIQDLVHNSNNFEIDHILPLSLSFDDSLANKVLVYAWTNQEKGQKTPYQVIDSMDAAWSFREMKDYVLNQKGIGKKKREYLLTTENIDKIEVKKKFIERNLVDTRYASRVVLNSIQAALKELDKDTKVSVIRGQFTSQLRRKWKIDKSRETYHHHAVDALIIAASSQLKLWQKQENPMFVDYGENQVVNKETGEILSVSDDDYKELVFQPPYQGFVNTISSKAFEDEILFSYQVDSKYNRKVSDATIYSTRKARLGKDKKEETYVLGKIKDIYSQDGFDAFIKRYKKDKTQFLMYQKDPLTWENVIEVILRDYPSEKLSEDGKKNVKCNPFEEYRRENGLICKYSKKGKGTPIKSLKYYDKKLGNCIDITPKGSKNEVVLQSLNPWRADLYFNPDTLKYELMGLKYSDLSFEKGTGKYHISQERYDEIKVKEGIGKNSEFKFTLYRNDLILIKDTESGEEELYRFLSRTMPNVKHYVELKPYDKERYDGGQELMKVFGNVANGGQCLKSLNKSNLSIYKVRTDVLGNKFFIKKEGDKPKLDFKNNKK
>NZ_CP046919.1|WP_004232469.1|122807_123224_-|nucleoside-diphosphate-kinase
MEKTFFMIKPDGVKRGLVGEVLKRIERRGFKIEKLEMRMATPELLEKHYEDLVDRPFFPLIVDFMTSGPVIAGVMSGEEVITSWRTMMGATNPKEALPGTIRGDFAQAPAEGAATFNIVHGSDSPESVEREIALWFGE
>NZ_CP046919.1|WP_166042920.1|123341_123581_-|type-II-toxin-antitoxin-system-HicB-family-antitoxin
MIKNYPAIFHNEANGRYWVEFPDFAGGTQGDNLEEARRNAKEFLSGVLETYYIEKMPLPDPSNLDTLCTCDGHVEFVEV
>NZ_CP046919.1|WP_134775434.1|123601_123772_-|NADH-quinone-oxidoreductase-subunit-L
MTFAWYFWLLFAVAWIFAITFWVKSSNISQKWLRITYVICGIIAFLLPFFWGWLVS
>NZ_CP046919.1|WP_166042922.1|123768_124428_-|TIGR01906-family-membrane-protein
MKNRIWTFSTWLWLLSFAVLVAIYGAWLIYPLEIDWLKLTLQVTITKDDLLKNFNVLMTYLTNPLSHTLAMPDFPSSASGLKHFGDVKHLFHLAQAVFVILLYPSWRFLKNSRAKKSLFLHQRTFTFAAFLPIVIAVAGLLIGFDQFFTLFHEALFPGDSSWLFNPATDPIIWVLPEEYFMHCFIIFFVAYEVMMLSLVATARKQLNHRLKNNERKDEK
>NZ_CP046919.1|WP_074481524.1|124417_125191_-|TIGR01457-family-HAD-type-hydrolase
MTYKGYLIDLDGTIYKGKDRIPAGERFIQRLQERQIPYVLVTNNSTRTPEKVQEMLATQFNVHTPLNTIYTATMATIDYMNDLNRGKTVYVIGETGLKTAIAEAGYVEDTENPAYVVVGLDTDLTYEKLAVATLAIQKGAVFIGTNPDLNIPTERGLMPGAGAINNLLEVATRVKPVYIGKPNAIIMNKALDVLGVKREEAIMVGDNYLTDIMAGIQNDIATLLVTTGFTKPEEVPTLPVKPDHVLASLDEWNFDEK
>NZ_CP046919.1|WP_157629189.1|125285_126014_-|acyl-[acyl-carrier-protein]-thioesterase
MGLSYQEKYQVPFYESDINQNMKLSQLLSLVLQVSGKQSLSLGMSDEYVFQTYNLVWIITEYAIEIDRLPKYTENIVIETVPTAYNKLFCYRDFNVYGEDGEKILTIHSTFVLMDYDTRKVHPVVDDIVDVYQVEKVKKIYRGPRYEGLENPEETLYHVRFFDLDLNGHVNNSKYLEWMYDVLDVNFLEKYIPHHINLKYVKEVQYGHDIKSRVERDGLTTKHEIVTQGVVRAQARIEWKEK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP046919_1	1.6\|116398\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116398-116427	30	NZ_CP046919.1	211964-211993	0	1.0
NZ_CP046919_1	1.8\|116530\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116530-116559	30	NZ_CP046919.1	209276-209305	0	1.0
NZ_CP046919_1	1.10\|116662\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116662-116691	30	NZ_CP046919.1	211640-211669	1	0.967

1. spacer 1.6|116398|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to position: 211964-211993, mismatch: 0, identity: 1.0

tcgattaggtagacgtcttcttgtgtaggg	CRISPR spacer
tcgattaggtagacgtcttcttgtgtaggg	Protospacer
******************************

2. spacer 1.8|116530|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to position: 209276-209305, mismatch: 0, identity: 1.0

taattctcgtcatcaaggtcgagaatggca	CRISPR spacer
taattctcgtcatcaaggtcgagaatggca	Protospacer
******************************

3. spacer 1.10|116662|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to position: 211640-211669, mismatch: 1, identity: 0.967

tttggtgacgctcattgcttacctccttaa	CRISPR spacer
tttagtgacgctcattgcttacctccttaa	Protospacer
***.**************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP046919_1	1.6\|116398\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116398-116427	30	MK448712	Streptococcus phage Javan237, complete genome	9460-9489	1	0.967
NZ_CP046919_1	1.6\|116398\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116398-116427	30	MK448880	Streptococcus phage Javan238, complete genome	9460-9489	1	0.967
NZ_CP046919_1	1.3\|116200\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116200-116229	30	MK448721	Streptococcus phage Javan263, complete genome	29417-29446	2	0.933
NZ_CP046919_1	1.3\|116200\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116200-116229	30	MK448879	Streptococcus phage Javan226, complete genome	30583-30612	2	0.933
NZ_CP046919_1	1.3\|116200\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116200-116229	30	MK448706	Streptococcus phage Javan221, complete genome	30623-30652	2	0.933
NZ_CP046919_1	1.3\|116200\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116200-116229	30	MK448704	Streptococcus phage Javan213, complete genome	34338-34367	5	0.833
NZ_CP046919_1	1.8\|116530\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116530-116559	30	AB967974	Aurantimonas phage AmM-1 DNA, complete sequence	35356-35385	5	0.833
NZ_CP046919_1	1.10\|116662\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116662-116691	30	NC_018285	Streptococcus phage YMC-2011, complete genome	31403-31432	6	0.8
NZ_CP046919_1	1.11\|116728\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116728-116757	30	NZ_CP053838	Aliiarcobacter faecis strain CCUG 66484 plasmid pAFAEC, complete sequence	8382-8411	6	0.8
NZ_CP046919_1	1.7\|116464\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116464-116493	30	MN694353	Marine virus AFVG_250M583, complete genome	16862-16891	7	0.767
NZ_CP046919_1	1.8\|116530\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116530-116559	30	CP011075	Brevibacillus laterosporus strain B9 plasmid unnamed1, complete sequence	701555-701584	7	0.767
NZ_CP046919_1	1.8\|116530\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116530-116559	30	NZ_CP021033	Rhizobium sp. NXC14 plasmid pRspNXC14c, complete sequence	524816-524845	7	0.767
NZ_CP046919_1	1.11\|116728\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116728-116757	30	JN638751	Bacillus phage G, complete genome	287069-287098	7	0.767
NZ_CP046919_1	1.11\|116728\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116728-116757	30	NZ_CP007807	Brevibacillus laterosporus LMG 15441 plasmid pBRLA33, complete sequence	131-160	7	0.767
NZ_CP046919_1	1.11\|116728\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116728-116757	30	MN693496	Marine virus AFVG_25M103, complete genome	337-366	7	0.767
NZ_CP046919_1	1.8\|116530\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116530-116559	30	NZ_CP030128	Indioceanicola profundi strain SCSIO 08040 plasmid unnamed2, complete sequence	152566-152595	8	0.733
NZ_CP046919_1	1.9\|116596\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116596-116625	30	MH319731	Marine virus AG-345-E02 Ga0172268_11 genomic sequence	71889-71918	8	0.733
NZ_CP046919_1	1.11\|116728\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116728-116757	30	MH327484	Marine virus AG-341-P01 Ga0172215_11 genomic sequence	24944-24973	8	0.733
NZ_CP046919_1	1.11\|116728\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116728-116757	30	AP018714	Enterococcus phage phiEF17H DNA, complete sequence	104348-104377	8	0.733
NZ_CP046919_1	1.8\|116530\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116530-116559	30	NZ_CP019037	Massilia putida strain 6NM-7 plasmid unnamed2, complete sequence	450330-450359	9	0.7
NZ_CP046919_1	1.11\|116728\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116728-116757	30	NZ_CP006994	Methylobacterium sp. AMS5 plasmid pAMS5b, complete sequence	8430-8459	9	0.7

1. spacer 1.6|116398|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to MK448712 (Streptococcus phage Javan237, complete genome) position: , mismatch: 1, identity: 0.967

tcgattaggtagacgtcttcttgtgtaggg	CRISPR spacer
tcgattaggtagacatcttcttgtgtaggg	Protospacer
**************.***************

2. spacer 1.6|116398|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to MK448880 (Streptococcus phage Javan238, complete genome) position: , mismatch: 1, identity: 0.967

tcgattaggtagacgtcttcttgtgtaggg	CRISPR spacer
tcgattaggtagacatcttcttgtgtaggg	Protospacer
**************.***************

3. spacer 1.3|116200|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to MK448721 (Streptococcus phage Javan263, complete genome) position: , mismatch: 2, identity: 0.933

ttgctagcttgatagttggcaagatttgtc	CRISPR spacer
ttgctagcttgatagttagcaagatttgtt	Protospacer
*****************.***********.

4. spacer 1.3|116200|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to MK448879 (Streptococcus phage Javan226, complete genome) position: , mismatch: 2, identity: 0.933

ttgctagcttgatagttggcaagatttgtc	CRISPR spacer
ttgctagcttgatagttagcaagattagtc	Protospacer
*****************.******** ***

5. spacer 1.3|116200|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to MK448706 (Streptococcus phage Javan221, complete genome) position: , mismatch: 2, identity: 0.933

ttgctagcttgatagttggcaagatttgtc	CRISPR spacer
ttgctagcttgatagttagcaagattagtc	Protospacer
*****************.******** ***

6. spacer 1.3|116200|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to MK448704 (Streptococcus phage Javan213, complete genome) position: , mismatch: 5, identity: 0.833

ttgctagcttgatagttggcaagatttgtc	CRISPR spacer
ttgcttgcttgatagctggcaagattagct	Protospacer
***** *********.********** *..

7. spacer 1.8|116530|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to AB967974 (Aurantimonas phage AmM-1 DNA, complete sequence) position: , mismatch: 5, identity: 0.833

taattctcgtcatcaaggtcgagaatggca	CRISPR spacer
tcaagctcgacatcaaggtcgagaacggca	Protospacer
* *  **** ***************.****

8. spacer 1.10|116662|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to NC_018285 (Streptococcus phage YMC-2011, complete genome) position: , mismatch: 6, identity: 0.8

tttggtgacgctcattgcttacctccttaa	CRISPR spacer
cttagatacactcattgcttacctcctaaa	Protospacer
.**.*  **.***************** **

9. spacer 1.11|116728|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP053838 (Aliiarcobacter faecis strain CCUG 66484 plasmid pAFAEC, complete sequence) position: , mismatch: 6, identity: 0.8

aatgttttatttacattataaccaacagta	CRISPR spacer
aatgtttaatttacattataaaaaccataa	Protospacer
******* *************  * **  *

10. spacer 1.7|116464|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to MN694353 (Marine virus AFVG_250M583, complete genome) position: , mismatch: 7, identity: 0.767

aatcgatgaggtcgtaatatatggcggatt------	CRISPR spacer
aattgatgaggtcgtaatata------atttcacta	Protospacer
***.*****************      ***

11. spacer 1.8|116530|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to CP011075 (Brevibacillus laterosporus strain B9 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

taattctcgtcatcaaggtcgagaatggca	CRISPR spacer
cccatttcgtcatgaaggtggagaatggca	Protospacer
.   *.******* ***** **********

12. spacer 1.8|116530|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP021033 (Rhizobium sp. NXC14 plasmid pRspNXC14c, complete sequence) position: , mismatch: 7, identity: 0.767

taattctcgtcatcaaggtcgagaatggca	CRISPR spacer
aagatctcggcatcaagctcgagaatgtga	Protospacer
 *. ***** ******* *********  *

13. spacer 1.11|116728|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to JN638751 (Bacillus phage G, complete genome) position: , mismatch: 7, identity: 0.767

aatgttttatttacattataaccaacagta	CRISPR spacer
ctatttttatttacattataataaacagtc	Protospacer
    *****************. ******

14. spacer 1.11|116728|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP007807 (Brevibacillus laterosporus LMG 15441 plasmid pBRLA33, complete sequence) position: , mismatch: 7, identity: 0.767

aatgttttatttacattataaccaacagta	CRISPR spacer
aatgtcttatttacactataacctattatt	Protospacer
*****.*********.******* *. .*

15. spacer 1.11|116728|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to MN693496 (Marine virus AFVG_25M103, complete genome) position: , mismatch: 7, identity: 0.767

aatgttttatttacattataaccaacagta----	CRISPR spacer
aatgttttatttagattat----aatactactct	Protospacer
************* *****    **.* **

16. spacer 1.8|116530|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP030128 (Indioceanicola profundi strain SCSIO 08040 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.733

taattctcgtcatcaaggtcgagaatggca	CRISPR spacer
ccattctcgtcggcaaggtcgagaacatcc	Protospacer
. *********. ************.. *

17. spacer 1.9|116596|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to MH319731 (Marine virus AG-345-E02 Ga0172268_11 genomic sequence) position: , mismatch: 8, identity: 0.733

cgccagaagactgtaagtatgtcatgattt	CRISPR spacer
tggatgaagactgtaagtatgttaagatga	Protospacer
.*   *****************.* ***

18. spacer 1.11|116728|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to MH327484 (Marine virus AG-341-P01 Ga0172215_11 genomic sequence) position: , mismatch: 8, identity: 0.733

aatgttttatttacattataaccaacagta	CRISPR spacer
gaatcaatacttacattatcaccaacagta	Protospacer
.*  .  **.********* **********

19. spacer 1.11|116728|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to AP018714 (Enterococcus phage phiEF17H DNA, complete sequence) position: , mismatch: 8, identity: 0.733

aatgttttatttacattataaccaacagta	CRISPR spacer
atagttttatttaaattataaccatttatc	Protospacer
*  ********** ********** . .*

20. spacer 1.8|116530|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP019037 (Massilia putida strain 6NM-7 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.7

taattctcgtcatcaaggtcgagaatggca	CRISPR spacer
gtgagatcgtcatcaaggtcgaggaaggcg	Protospacer
  .   *****************.* ***.

21. spacer 1.11|116728|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP006994 (Methylobacterium sp. AMS5 plasmid pAMS5b, complete sequence) position: , mismatch: 9, identity: 0.7

aatgttttatttacattataaccaacagta	CRISPR spacer
ttcgttttatttacataataaccatccaag	Protospacer
  .************* ******* * . .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

133178 : 241952

135

Streptococcus_phage(77.78%)

capsid,terminase,head,tail,portal,holin,integrase,protease

attL 240672:240693|attR 248288:248309

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_166042924.1\|133178_134453_-	LysM peptidoglycan-binding domain-containing protein	A0A0S2MYF3	Enterococcus_phage	1.8e-145	62.7
WP_107374513.1\|134442_134640_-	hypothetical protein	Q938J5	Temperate_phage	6.8e-12	55.7
WP_107374556.1\|134636_134828_-	hypothetical protein	B0YL75	Streptococcus_virus	2.6e-24	90.5
WP_166042926.1\|134885_135218_-	hypothetical protein	A1EAB4	Streptococcus_phage	8.8e-20	42.0
WP_166042928.1\|135240_137919_-	hypothetical protein	A0A1S5SFF9	Streptococcus_phage	2.3e-89	37.0
WP_166042929.1\|137992_138232_-	hypothetical protein	NA	NA	NA	NA
WP_166042930.1\|138243_139371_-	hypothetical protein	A0A1B1IN38	Lactococcus_phage	5.0e-107	55.8
WP_166042932.1\|139385_141074_-	hypothetical protein	Q2I7P5	Streptococcus_phage	1.8e-108	44.6
WP_166042934.1\|141076_142573_-\|tail	phage tail family protein	A0A0B5A078	Streptococcus_phage	1.3e-49	28.3
WP_166042935.1\|142576_144949_-\|tail	phage tail protein	Q77MU4	Lactococcus_phage	1.6e-110	49.2
WP_166042937.1\|144938_145319_-	DUF5361 domain-containing protein	Q9F4J4	Streptococcus_phage	8.8e-32	56.6
WP_166042938.1\|145333_145588_-	hypothetical protein	A0A0B5A2F3	Streptococcus_phage	5.3e-17	52.3
WP_166042940.1\|145591_146170_-\|tail	phage tail protein	Q9F4J6	Streptococcus_phage	1.1e-57	63.6
WP_166042942.1\|146181_146517_-	hypothetical protein	A0A1B1IMT0	Lactococcus_phage	2.3e-28	59.1
WP_166042944.1\|146513_146753_-	hypothetical protein	A0A0B5A7G2	Streptococcus_phage	4.0e-22	67.1
WP_166042946.1\|146745_147084_-	hypothetical protein	Q7Y4I1	Streptococcus_phage	1.9e-38	66.1
WP_166042948.1\|147076_147466_-	hypothetical protein	M1NRT5	Streptococcus_phage	2.6e-47	77.3
WP_166042949.1\|147487_147628_-	hypothetical protein	NA	NA	NA	NA
WP_166042951.1\|147627_148548_-\|capsid	phage major capsid protein	A0A126GGI3	Streptococcus_phage	9.3e-136	80.1
WP_166042953.1\|148552_149008_-	DUF4355 domain-containing protein	A0A126GGH5	Streptococcus_phage	1.0e-34	59.0
WP_166042955.1\|149083_150496_-\|terminase	terminase	M1PFG2	Streptococcus_phage	6.2e-240	83.1
WP_166042958.1\|150548_150689_-	hypothetical protein	NA	NA	NA	NA
WP_166042960.1\|150748_150955_-	hypothetical protein	Q708N1	Streptococcus_phage	8.1e-24	75.4
WP_166044322.1\|150920_151397_-	MafB	Q7Y4I9	Streptococcus_phage	2.2e-40	53.2
WP_166042962.1\|152124_153387_-\|portal	phage portal protein	A0A126GGJ2	Streptococcus_phage	1.9e-192	78.6
WP_166042964.1\|153508_153859_-	HNH endonuclease	A0A1S5SG82	Streptococcus_phage	4.0e-47	81.5
WP_107374543.1\|153969_154395_-	DUF1492 domain-containing protein	A0A1X9I5N2	Streptococcus_phage	1.3e-44	69.5
WP_166042966.1\|155037_155250_-	hypothetical protein	A0A1S5SEA6	Streptococcus_phage	7.6e-17	62.3
WP_166042968.1\|155262_155427_-	hypothetical protein	NA	NA	NA	NA
WP_166042970.1\|155444_155609_-	hypothetical protein	NA	NA	NA	NA
WP_166042972.1\|155610_156003_-	hypothetical protein	A0A2H4JAX8	uncultured_Caudovirales_phage	1.6e-12	37.0
WP_166042974.1\|156214_156739_-	DUF1642 domain-containing protein	B3GVZ2	Streptococcus_phage	1.7e-09	41.0
WP_166042976.1\|156762_156903_-	hypothetical protein	NA	NA	NA	NA
WP_166042978.1\|156895_157216_-	hypothetical protein	NA	NA	NA	NA
WP_166042980.1\|157196_157376_-	hypothetical protein	NA	NA	NA	NA
WP_166042982.1\|157365_157614_-	hypothetical protein	NA	NA	NA	NA
WP_166042985.1\|157598_158075_-	RusA family crossover junction endodeoxyribonuclease	A0A286QS25	Streptococcus_phage	4.6e-62	71.1
WP_166042987.1\|158071_158398_-	hypothetical protein	E8ZD56	Streptococcus_phage	7.8e-29	59.8
WP_166042989.1\|158409_158853_-	single-stranded DNA-binding protein	Q938M7	Temperate_phage	2.9e-42	63.3
WP_166042990.1\|158861_159860_-	DUF1351 domain-containing protein	E8ZD61	Streptococcus_phage	7.3e-118	66.5
WP_166042992.1\|159874_160630_-	phage recombination protein Bet	A0A141E1Z7	Streptococcus_phage	3.5e-96	73.4
WP_094141147.1\|160629_160818_-	hypothetical protein	A0A1S5S9Y3	Streptococcus_phage	1.3e-12	59.3
WP_166042993.1\|160814_161039_-	hypothetical protein	NA	NA	NA	NA
WP_166042994.1\|161039_161258_-	hypothetical protein	NA	NA	NA	NA
WP_166042995.1\|161260_161443_-	hypothetical protein	NA	NA	NA	NA
WP_166042996.1\|161445_162333_-	DnaD domain protein	J7KBV5	Streptococcus_phage	1.6e-55	82.0
WP_166044324.1\|162364_163150_-	DNA methyltransferase	U4KJA1	Streptococcus_phage	2.3e-119	80.2
WP_166042997.1\|163160_163337_-	hypothetical protein	NA	NA	NA	NA
WP_166042998.1\|163338_163650_-	excisionase	A0A1S5SA25	Streptococcus_phage	4.7e-39	72.8
WP_166042999.1\|163734_164073_-	hypothetical protein	A0A1P8VVU1	Streptococcus_phage	3.9e-31	64.4
WP_166044326.1\|164263_164479_-	transcriptional regulator	M1Q1B4	Streptococcus_phage	6.9e-26	84.3
WP_074629780.1\|164783_165161_+	helix-turn-helix domain-containing protein	A0A1S5SFC6	Streptococcus_phage	1.0e-40	70.2
WP_166043000.1\|165189_165570_+	ImmA/IrrE family metallo-endopeptidase	A0A1S5SFH2	Streptococcus_phage	1.1e-39	65.6
WP_166043002.1\|165623_166376_+	hypothetical protein	A0A1X9I5E4	Streptococcus_phage	9.8e-59	66.0
WP_166043003.1\|166517_167669_+\|integrase	site-specific integrase	C5IUL7	Streptococcus_phage	3.7e-105	53.1
WP_004232506.1\|167756_169055_-	phosphopyruvate hydratase	W6LP63	Streptococcus_phage	1.3e-228	92.6
WP_074564035.1\|169261_169711_+	YueI family protein	W6LLD2	Streptococcus_phage	6.1e-32	53.0
WP_166043004.1\|169707_170823_-	glycerate kinase	W6LM47	Streptococcus_phage	6.3e-94	61.5
WP_166043005.1\|170967_177594_-	pullulanase	NA	NA	NA	NA
WP_074564039.1\|177799_178114_-	phosphoribosyl-ATP diphosphatase	NA	NA	NA	NA
WP_039696592.1\|178125_178446_-	phosphoribosyl-AMP cyclohydrolase	A0A2H4UVM0	Bodo_saltans_virus	2.3e-09	33.0
WP_074965180.1\|178442_179201_-	imidazole glycerol phosphate synthase subunit HisF	NA	NA	NA	NA
WP_166043006.1\|179204_179924_-	1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase	A0A2H4UVM0	Bodo_saltans_virus	8.9e-09	23.4
WP_006532647.1\|179971_180580_-	imidazole glycerol phosphate synthase subunit HisH	NA	NA	NA	NA
WP_039696589.1\|180652_181237_-	imidazoleglycerol-phosphate dehydratase HisB	NA	NA	NA	NA
WP_158914202.1\|181262_181910_-	phosphoserine phosphatase SerB	NA	NA	NA	NA
WP_158914204.1\|181902_183180_-	histidinol dehydrogenase	NA	NA	NA	NA
WP_006532651.1\|183176_183824_-	ATP phosphoribosyltransferase	NA	NA	NA	NA
WP_039696586.1\|183823_184792_-	ATP phosphoribosyltransferase	NA	NA	NA	NA
WP_158914206.1\|184808_185876_-	histidinol-phosphate transaminase	NA	NA	NA	NA
WP_074564051.1\|186327_188052_-	septation ring formation regulator EzrA	NA	NA	NA	NA
WP_074560621.1\|188157_190110_-	DNA topoisomerase (ATP-hydrolyzing) subunit B	G3M9Z3	Bacillus_virus	6.8e-144	45.4
WP_166043007.1\|190110_190671_-	HAD-IA family hydrolase	NA	NA	NA	NA
WP_166043008.1\|190823_192035_-	FtsW/RodA/SpoVE family cell cycle protein	NA	NA	NA	NA
WP_166043009.1\|192445_192796_-	hypothetical protein	NA	NA	NA	NA
WP_166043011.1\|192854_193241_-	hypothetical protein	B3GW25	Streptococcus_phage	2.9e-22	50.9
WP_166043013.1\|193939_194785_-	peptidoglycan hydrolase	W6LMV8	Streptococcus_phage	9.5e-119	72.4
WP_166043015.1\|194781_195108_-\|holin	phage holin	A0A286QRN1	Streptococcus_phage	2.3e-41	80.6
WP_166043017.1\|195152_195485_-	hypothetical protein	Q56S82	Streptococcus_virus	1.4e-46	90.0
WP_166043019.1\|195498_195645_-	hypothetical protein	A0A286QNV5	Streptococcus_phage	1.2e-16	91.3
WP_166043021.1\|195670_196042_-	DUF1366 domain-containing protein	A0A286QT32	Streptococcus_phage	7.8e-25	49.2
WP_166043023.1\|196054_198145_-	hypothetical protein	M1IR90	Streptococcus_phage	2.9e-108	36.2
WP_166043025.1\|198157_199708_-	hypothetical protein	Q94MX2	Streptococcusphage	1.8e-46	35.2
WP_166043027.1\|199646_199865_-	hypothetical protein	NA	NA	NA	NA
WP_166043029.1\|199882_201007_-	hypothetical protein	A0A1B1IN38	Lactococcus_phage	1.3e-107	53.6
WP_166043031.1\|201033_202785_-	hypothetical protein	Q9MCJ8	Streptococcus_virus	5.8e-195	57.8
WP_166044328.1\|202785_204342_-\|tail	phage tail protein	A0A1S5PRQ3	Streptococcus_phage	1.4e-195	60.8
WP_166043033.1\|204347_208931_-	tape measure protein	A0A286QPN7	Streptococcus_phage	1.1e-309	58.1
WP_166043035.1\|209139_209502_-\|tail	phage tail protein	F8HGT7	Streptococcus_phage	4.4e-33	67.2
WP_094141002.1\|209563_210178_-\|tail	phage tail protein	O64291	Streptococcus_virus	1.3e-77	71.0
WP_166043037.1\|210194_210569_-	DUF806 family protein	A0A286QQM7	Streptococcus_phage	4.6e-41	65.9
WP_094141000.1\|210568_210991_-	HK97 gp10 family phage protein	A0A286QQY0	Streptococcus_phage	6.1e-50	72.5
WP_166043039.1\|210990_211344_-\|head	phage head closure protein	O64288	Streptococcus_virus	2.8e-40	68.8
WP_166043041.1\|211336_211654_-\|head,tail	phage gp6-like head-tail connector protein	A0A286QNI5	Streptococcus_phage	1.0e-33	71.4
WP_166043043.1\|211665_212904_-\|capsid	phage major capsid protein	A0A2I6QQY9	Streptococcus_phage	2.6e-96	49.0
WP_094140996.1\|212918_213605_-\|protease	Clp protease ClpP	A0A2P0VGN2	Streptococcus_phage	2.0e-74	63.6
WP_166043045.1\|213591_214764_-\|portal	phage portal protein	Q9MCK6	Streptococcus_virus	3.0e-155	70.8
WP_166043047.1\|214794_214953_-	hypothetical protein	NA	NA	NA	NA
WP_166043048.1\|214952_215138_-	DUF1056 family protein	A0A2I6QQZ6	Streptococcus_phage	1.1e-16	77.0
WP_166044330.1\|215151_217029_-\|terminase	terminase large subunit	A0A286QNL8	Streptococcus_phage	0.0e+00	91.2
WP_166043050.1\|217045_217504_-\|terminase	phage terminase small subunit P27 family	A0A286QTA0	Streptococcus_phage	5.4e-76	90.8
WP_166043052.1\|217685_218204_-	HNH endonuclease	Q9XJW2	Streptococcus_virus	7.2e-61	66.3
WP_166043054.1\|218458_218863_-	DUF1492 domain-containing protein	A0A2I6QQS5	Streptococcus_phage	6.9e-35	57.9
WP_166043055.1\|219199_219607_-	hypothetical protein	Q9AZN1	Lactococcus_phage	6.5e-33	58.8
WP_166043057.1\|219596_219758_-	hypothetical protein	NA	NA	NA	NA
WP_166043059.1\|219754_220303_-	DUF1642 domain-containing protein	A0A286QMN0	Streptococcus_phage	9.2e-06	28.4
WP_166043061.1\|220332_220767_-	hypothetical protein	NA	NA	NA	NA
WP_166043062.1\|220750_221005_-	hypothetical protein	NA	NA	NA	NA
WP_166044332.1\|221310_222600_-	helicase	A0A1S5SB13	Streptococcus_phage	8.3e-207	82.8
WP_166043064.1\|222641_223460_-	DNA primase	B3GVY7	Streptococcus_phage	2.0e-121	78.4
WP_166043065.1\|223488_224016_-	hypothetical protein	X2L082	Streptococcus_phage	3.5e-63	70.3
WP_166043066.1\|224035_224794_-	AAA family ATPase	B3GVY5	Streptococcus_phage	1.2e-112	83.3
WP_166043067.1\|225985_226519_-	endonuclease	B3GVX7	Streptococcus_phage	8.8e-38	48.9
WP_166043068.1\|226496_226967_-	hypothetical protein	A0A141E0U8	Streptococcus_phage	1.8e-63	74.7
WP_166043069.1\|226967_227450_-	siphovirus Gp157 family protein	A0A1P8VVS5	Streptococcus_phage	3.1e-50	68.1
WP_166043070.1\|227584_227920_-	hypothetical protein	A0A1X9I5N1	Streptococcus_phage	3.1e-20	51.0
WP_166043071.1\|227973_228174_-	hypothetical protein	NA	NA	NA	NA
WP_166043072.1\|228175_228445_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_166043074.1\|228665_228836_-	hypothetical protein	NA	NA	NA	NA
WP_166043076.1\|229008_229239_-	DUF739 family protein	O34036	Streptococcus_phage	1.8e-27	81.1
WP_166043078.1\|229413_229806_+	helix-turn-helix domain-containing protein	O34035	Streptococcus_phage	9.4e-45	73.6
WP_166043080.1\|229792_230179_+	ImmA/IrrE family metallo-endopeptidase	A0A1P8VVK5	Streptococcus_phage	1.3e-27	48.0
WP_166043082.1\|230200_230632_+	hypothetical protein	NA	NA	NA	NA
WP_166043084.1\|230799_231867_+\|integrase	site-specific integrase	A0A1X9I680	Streptococcus_phage	1.2e-115	58.8
WP_166043086.1\|232076_232424_-	50S ribosomal protein L19	NA	NA	NA	NA
WP_166043088.1\|232570_233791_-	voltage-gated chloride channel protein	A0A1X9I5Z9	Streptococcus_phage	4.3e-96	51.3
WP_166043091.1\|233804_234092_-	chorismate mutase	NA	NA	NA	NA
WP_166043093.1\|234126_234834_-	TVP38/TMEM64 family protein	NA	NA	NA	NA
WP_039696579.1\|234918_236304_-	Fe-S cluster assembly protein SufB	NA	NA	NA	NA
WP_006532664.1\|236389_236833_-	flavodoxin	NA	NA	NA	NA
WP_166043095.1\|236874_237894_-	adenosine deaminase	NA	NA	NA	NA
WP_039696576.1\|238016_239168_-	iron-containing alcohol dehydrogenase	NA	NA	NA	NA
WP_166043097.1\|239347_240289_+	bifunctional oligoribonuclease/PAP phosphatase NrnA	NA	NA	NA	NA
WP_021142736.1\|240447_240693_+	type B 50S ribosomal protein L31	NA	NA	NA	NA
240672:240693	attL	NA	NA	NA	NA
WP_009853866.1\|240794_241952_-\|integrase	site-specific integrase	A0A1S5S7K9	Streptococcus_phage	9.2e-40	30.6
WP_009853866.1\|240794_241952_-\|integrase	site-specific integrase	A0A1S5S7K9	Streptococcus_phage	9.2e-40	30.6
248288:248309	attR	NA	NA	NA	NA

DBSCAN-SWA_2

407370 : 417222

Streptococcus_phage(75.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_039696452.1\|407370_408462_-	3-phosphoserine/phosphohydroxythreonine transaminase	M1Q1P2	Streptococcus_phage	4.6e-174	82.0
WP_074626291.1\|408596_409226_+	copper homeostasis protein CutC	NA	NA	NA	NA
WP_039696436.1\|409339_409681_-	P-II family nitrogen regulator	NA	NA	NA	NA
WP_039696435.1\|409761_410997_-	ammonium transporter	NA	NA	NA	NA
WP_166043239.1\|411352_412219_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	2.1e-121	76.4
WP_039696433.1\|412228_412549_-	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	2.6e-29	61.3
WP_074602650.1\|412541_413342_-	signal peptidase II	NA	NA	NA	NA
WP_166043241.1\|413338_414214_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	1.2e-71	49.0
WP_166043243.1\|414232_414859_-	dTMP kinase	M1PSC7	Streptococcus_phage	1.8e-69	65.6
WP_166043244.1\|414951_415611_-	CBS domain-containing protein	M1NSC5	Streptococcus_phage	4.4e-71	64.2
WP_024343676.1\|415747_416458_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.4e-16	27.2
WP_039696427.1\|416457_417222_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	7.2e-17	25.2

DBSCAN-SWA_3

610486 : 705176

Bacillus_phage(26.67%)

transposase,bacteriocin,tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_039696260.1\|610486_611497_-\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	1.8e-60	40.2
WP_074602918.1\|611493_611946_-	ribosomal protein S18-alanine N-acetyltransferase	NA	NA	NA	NA
WP_080728286.1\|611929_612622_-\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB	NA	NA	NA	NA
WP_074564447.1\|612810_613041_+	DNA-dependent RNA polymerase auxiliary subunit epsilon family protein	NA	NA	NA	NA
WP_039696257.1\|613042_614725_+	ribonuclease J	NA	NA	NA	NA
WP_166043376.1\|614825_615488_-	CHAP domain-containing protein	NA	NA	NA	NA
WP_039696251.1\|615675_617115_-	glutamate synthase subunit beta	NA	NA	NA	NA
WP_166043378.1\|617116_621634_-	glutamate synthase large subunit	NA	NA	NA	NA
WP_074560916.1\|621824_623171_-	type I glutamate--ammonia ligase	NA	NA	NA	NA
WP_015695674.1\|623217_623589_-	MerR family transcriptional regulator	Q9EYF2	Enterobacteria_phage	2.4e-05	34.1
WP_039696246.1\|623670_624216_-	aromatic acid exporter family protein	NA	NA	NA	NA
WP_074602933.1\|624349_625546_-	phosphoglycerate kinase	NA	NA	NA	NA
WP_039696243.1\|625730_626744_-	type I glyceraldehyde-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_020917479.1\|626951_629030_-	elongation factor G	E4ZFJ7	Streptococcus_phage	4.8e-63	28.8
WP_004233289.1\|629231_629702_-	30S ribosomal protein S7	NA	NA	NA	NA
WP_003066537.1\|629723_630137_-	30S ribosomal protein S12	NA	NA	NA	NA
WP_039696241.1\|630382_631198_-	pur operon repressor	NA	NA	NA	NA
WP_052071092.1\|631770_632010_+	hypothetical protein	NA	NA	NA	NA
WP_166043380.1\|632110_633049_-	HD domain-containing protein	NA	NA	NA	NA
WP_006531897.1\|633038_634313_-	DNA recombination protein RmuC	NA	NA	NA	NA
WP_166043382.1\|634314_634947_-	thiamine diphosphokinase	NA	NA	NA	NA
WP_006531895.1\|634939_635602_-	ribulose-phosphate 3-epimerase	NA	NA	NA	NA
WP_006531894.1\|635608_636481_-	ribosome small subunit-dependent GTPase A	NA	NA	NA	NA
WP_052071091.1\|636799_637534_-	response regulator transcription factor	A0A1V0E029	Clostridioides_phage	2.8e-18	27.2
WP_166044344.1\|638194_639541_-	GHKL domain-containing protein	NA	NA	NA	NA
WP_166044346.1\|639567_640938_-	GHKL domain-containing protein	NA	NA	NA	NA
WP_166043384.1\|640942_642328_-	GHKL domain-containing protein	NA	NA	NA	NA
WP_074626913.1\|642676_642970_-\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA
WP_158914537.1\|642997_643303_-\|bacteriocin	bacteriocin immunity protein	Q9AZK7	Lactococcus_phage	3.3e-05	41.3
WP_039696228.1\|643315_643465_-	hypothetical protein	NA	NA	NA	NA
WP_158914538.1\|643727_643880_+	hypothetical protein	NA	NA	NA	NA
WP_166043386.1\|643902_645228_-	GHKL domain-containing protein	NA	NA	NA	NA
WP_166043387.1\|645232_645964_-	response regulator transcription factor	NA	NA	NA	NA
WP_074626894.1\|646731_647421_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_159428313.1\|647485_647638_-	hypothetical protein	NA	NA	NA	NA
WP_159428314.1\|647651_647792_-\|bacteriocin	ComC/BlpC family leader-containing pheromone/bacteriocin	NA	NA	NA	NA
WP_074626895.1\|647814_648423_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_159428316.1\|648397_648562_-\|bacteriocin	lactococcin G-beta/enterocin 1071B family bacteriocin	NA	NA	NA	NA
WP_107374736.1\|648564_648720_-\|bacteriocin	ComC/BlpC family leader-containing pheromone/bacteriocin	NA	NA	NA	NA
WP_074626896.1\|648959_651107_+	peptide cleavage/export ABC transporter	W8CYL7	Bacillus_phage	3.0e-44	28.5
WP_166043389.1\|651116_652499_+\|bacteriocin	bacteriocin secretion accessory protein	NA	NA	NA	NA
WP_166043391.1\|652524_652704_-	hypothetical protein	NA	NA	NA	NA
WP_166043393.1\|653043_653718_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_166043395.1\|653750_654440_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_166043397.1\|654433_654616_-\|bacteriocin	ComC/BlpC family leader-containing pheromone/bacteriocin	NA	NA	NA	NA
WP_074564489.1\|654985_655858_-	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	NA	NA	NA	NA
WP_166043399.1\|655946_656471_-	DUF1697 domain-containing protein	NA	NA	NA	NA
WP_074603284.1\|656467_657037_-	ribonuclease M5	NA	NA	NA	NA
WP_074602974.1\|657029_657800_-	TatD family hydrolase	NA	NA	NA	NA
WP_166043401.1\|657964_659530_+	ABC transporter ATP-binding protein	A0A2H4UU96	Bodo_saltans_virus	1.0e-17	27.4
WP_158914547.1\|659670_660876_+	MFS transporter	NA	NA	NA	NA
WP_166043403.1\|660999_662271_-	2-hydroxycarboxylate transporter family protein	NA	NA	NA	NA
WP_004233312.1\|662292_663915_-	NAD-dependent malic enzyme	NA	NA	NA	NA
WP_166043405.1\|664073_664955_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_166043407.1\|665008_666274_-	D-alanyl-lipoteichoic acid biosynthesis protein DltD	NA	NA	NA	NA
WP_015695707.1\|666266_666506_-	D-alanine--poly(phosphoribitol) ligase subunit DltC	NA	NA	NA	NA
WP_166043409.1\|666538_667801_-	D-alanyl-lipoteichoic acid biosynthesis protein DltB	A0A125RNP0	Pseudomonas_phage	2.1e-21	29.2
WP_158914551.1\|667797_669336_-	D-alanine--poly(phosphoribitol) ligase subunit DltA	A0A2K9L3I8	Tupanvirus	3.6e-39	28.1
WP_020917506.1\|669351_669474_-	teichoic acid D-Ala incorporation-associated protein DltX	NA	NA	NA	NA
WP_166044348.1\|669483_670644_-	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	2.4e-19	30.1
WP_157629414.1\|670637_671327_-	response regulator	W8CYM9	Bacillus_phage	2.0e-29	35.0
WP_166043411.1\|671649_672444_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_074564517.1\|672602_673244_-	family 16 glycosylhydrolase	NA	NA	NA	NA
WP_166043413.1\|673271_674717_-	family 16 glycosylhydrolase	NA	NA	NA	NA
WP_074560955.1\|674741_675587_-	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_074564520.1\|675586_676531_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_074482397.1\|676690_678058_-	carbohydrate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_166043415.1\|678437_681137_+	cellobiose phosphorylase	NA	NA	NA	NA
WP_166043418.1\|681157_683569_+	N,N'-diacetylchitobiose phosphorylase	NA	NA	NA	NA
WP_074560960.1\|683948_684662_-	family 16 glycosylhydrolase	NA	NA	NA	NA
WP_015695712.1\|685052_685226_-	hypothetical protein	NA	NA	NA	NA
WP_074482394.1\|685374_685584_-	CsbD family protein	NA	NA	NA	NA
WP_002885866.1\|685714_685849_-	50S ribosomal protein L34	NA	NA	NA	NA
WP_158914565.1\|686040_686442_-	DUF3021 family protein	NA	NA	NA	NA
WP_158914567.1\|686452_686908_-	LytTR family transcriptional regulator	NA	NA	NA	NA
WP_166043420.1\|686921_687761_-	ABC transporter permease	NA	NA	NA	NA
WP_166043422.1\|687762_688614_-	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	5.4e-21	31.1
WP_074560965.1\|688735_689743_-	protein jag	NA	NA	NA	NA
WP_039696185.1\|689755_690571_-	membrane protein insertase YidC	NA	NA	NA	NA
WP_006531772.1\|690554_690914_-	ribonuclease P protein component	NA	NA	NA	NA
WP_166043424.1\|691054_692449_-	argininosuccinate lyase	NA	NA	NA	NA
WP_166043426.1\|692798_693989_-	argininosuccinate synthase	NA	NA	NA	NA
WP_166043428.1\|694187_695117_-	ABC transporter ATP-binding protein	M1IB70	Acanthocystis_turfacea_Chlorella_virus	1.7e-07	24.6
WP_015695757.1\|695109_696177_-	ABC transporter ATP-binding protein	A0A2R8FFL6	Cedratvirus	2.0e-09	26.1
WP_015695758.1\|696185_697112_-	ABC transporter permease	NA	NA	NA	NA
WP_134775673.1\|697111_698611_-	ABC transporter permease	NA	NA	NA	NA
WP_166043430.1\|698671_700645_-	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_166043432.1\|700916_702083_-	MFS transporter	NA	NA	NA	NA
WP_166043261.1\|702288_703640_-\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	1.4e-66	51.8
WP_074626856.1\|703718_705176_-\|tRNA	glutamate--tRNA ligase	NA	NA	NA	NA

DBSCAN-SWA_4

844209 : 852424

Staphylococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_166043567.1\|844209_844875_-	transglycosylase SLT domain-containing protein	Q4Z8Z7	Staphylococcus_phage	1.4e-21	73.6
WP_039696098.1\|845127_845730_-	LysM peptidoglycan-binding domain-containing protein	A0A096XT26	Enterococcus_phage	9.1e-23	47.3
WP_039696097.1\|845868_846666_-	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
WP_166043569.1\|846658_847501_-	energy-coupling factor transporter ATPase	A0A2H4PQG7	Staphylococcus_phage	2.3e-16	29.5
WP_039696095.1\|847476_848316_-	energy-coupling factor transporter ATPase	W8CYL7	Bacillus_phage	2.2e-14	29.6
WP_039696094.1\|848312_848867_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
WP_166043571.1\|848879_849824_-	hypothetical protein	NA	NA	NA	NA
WP_039696092.1\|849889_851179_-	insulinase family protein	A0A0G2Y5U8	Acanthamoeba_polyphaga_mimivirus	6.5e-18	32.1
WP_166043573.1\|851179_852424_-	insulinase family protein	A0A1X9I714	Streptococcus_phage	4.2e-91	43.7

DBSCAN-SWA_5

1101542 : 1121975

Streptococcus_phage(94.74%)

integrase

attL 1093213:1093227|attR 1127204:1127218

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1093213:1093227	attL	NA	NA	NA	NA
WP_039697537.1\|1101542_1102157_-	peptide deformylase	E3SLL2	Synechococcus_phage	2.5e-12	38.8
WP_039697538.1\|1102223_1102868_-	cyclic nucleotide-binding domain-containing protein	NA	NA	NA	NA
WP_158914814.1\|1102959_1104123_+	MFS transporter	NA	NA	NA	NA
WP_000420682.1\|1104451_1104766_+	YdcP family protein	A0A1S5SF38	Streptococcus_phage	5.2e-54	100.0
WP_000985015.1\|1104781_1105168_+	YdcP family protein	A0A1S5SF96	Streptococcus_phage	3.0e-64	100.0
WP_166043687.1\|1105196_1106582_+	DNA translocase FtsK	A0A1S5SFB5	Streptococcus_phage	3.2e-265	99.8
WP_000398284.1\|1106760_1107966_+	XRE family transcriptional regulator	A0A1S5SEX3	Streptococcus_phage	2.8e-233	100.0
WP_001009056.1\|1108008_1108230_+	hypothetical protein	A0A1S5SEY0	Streptococcus_phage	4.3e-31	100.0
WP_000342539.1\|1108346_1108844_+	antirestriction protein ArdA	A0A1S5SF25	Streptococcus_phage	1.7e-91	100.0
WP_000506270.1\|1108818_1109325_+	conjugal transfer protein	A0A1S5SEX7	Streptococcus_phage	8.6e-91	100.0
WP_000331160.1\|1109308_1111756_+	ATP-binding protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	100.0
WP_000804748.1\|1111758_1113936_+	membrane protein	A0A1S5SF30	Streptococcus_phage	0.0e+00	100.0
WP_000769868.1\|1113932_1114934_+	peptidase P60	A0A1S5SEZ8	Streptococcus_phage	5.0e-191	100.0
WP_001224319.1\|1114930_1115863_+	conjugal transfer protein	A0A1S5SF22	Streptococcus_phage	1.1e-171	100.0
WP_001791010.1\|1116107_1116224_+	tetracycline resistance determinant leader peptide	NA	NA	NA	NA
WP_166043689.1\|1116239_1118159_+	tetracycline resistance ribosomal protection protein Tet(M)	A0A1S5SF82	Streptococcus_phage	0.0e+00	96.9
WP_000336323.1\|1118277_1118445_+	conjugal transfer protein	D0R0F6	Streptococcus_phage	1.6e-14	68.0
WP_001227347.1\|1118504_1118858_-	helix-turn-helix transcriptional regulator	A0A1S5SFA6	Streptococcus_phage	1.3e-58	100.0
WP_000804885.1\|1119362_1119785_+	sigma-70 family RNA polymerase sigma factor	A0A1S5SEW0	Streptococcus_phage	2.5e-72	100.0
WP_000857133.1\|1119781_1120012_+	helix-turn-helix domain-containing protein	A0A1S5SEX1	Streptococcus_phage	2.7e-36	100.0
WP_000814511.1\|1120472_1120676_+	excisionase	A0A1S5SF07	Streptococcus_phage	4.0e-31	100.0
WP_001291561.1\|1120757_1121975_+\|integrase	tyrosine-type recombinase/integrase	A0A1S5SEW7	Streptococcus_phage	3.7e-233	100.0
1127204:1127218	attR	NA	NA	NA	NA

DBSCAN-SWA_6

1451185 : 1459200

Staphylococcus_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_166043894.1\|1451185_1452241_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A1V0SE20	Indivirus	7.1e-39	33.3
WP_166043896.1\|1452240_1452843_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	6.3e-32	39.3
WP_166043898.1\|1452843_1454022_+	GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	2.4e-104	50.8
WP_166043900.1\|1454033_1454495_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	7.9e-43	56.7
WP_166043902.1\|1454557_1455124_-	energy-coupled thiamine transporter ThiT	NA	NA	NA	NA
WP_166043903.1\|1455390_1456356_-	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A096XT60	Enterococcus_phage	1.5e-128	70.5
WP_166043905.1\|1456742_1458902_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	A8E2R1	Enterococcus_phage	8.0e-263	62.3
WP_014334480.1\|1458972_1459200_-	glutaredoxin-like protein NrdH	A0A0M7REK7	Lactobacillus_phage	1.3e-11	42.9

DBSCAN-SWA_7

1679319 : 1687833

Streptococcus_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_157628956.1\|1679319_1679529_-	hypothetical protein	Q7Y4M2	Streptococcus_phage	3.6e-27	87.0
WP_039696960.1\|1679990_1680572_+	thymidine kinase	A0A249XZX5	Enterococcus_phage	1.3e-50	55.4
WP_074482165.1\|1680608_1681688_+	peptide chain release factor 1	NA	NA	NA	NA
WP_166044071.1\|1681687_1682518_+	peptide chain release factor N(5)-glutamine methyltransferase	NA	NA	NA	NA
WP_074625803.1\|1682510_1683110_+	threonylcarbamoyl-AMP synthase	A0A291ATS8	Pandoravirus	2.5e-17	30.6
WP_074868785.1\|1683191_1684442_+	serine hydroxymethyltransferase	A0A240F2Y9	Aeromonas_phage	7.3e-99	53.5
WP_039696955.1\|1684483_1685461_+	nucleoid-associated protein	NA	NA	NA	NA
WP_074601803.1\|1685460_1686063_+	lysozyme family protein	A0A223LKM8	Bacillus_phage	4.1e-23	44.5
WP_166044073.1\|1686108_1687833_+	ABC transporter ATP-binding protein	A0A076FI99	Aureococcus_anophage	5.6e-09	20.9

DBSCAN-SWA_8

1726679 : 1735330

Streptococcus_phage(71.43%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_074563632.1\|1726679_1727366_+	helix-turn-helix transcriptional regulator	E8ZDN4	Streptococcus_phage	1.1e-56	48.3
WP_074563634.1\|1727367_1727571_+	hypothetical protein	D0R0A4	Streptococcus_phage	6.4e-13	52.3
WP_166044125.1\|1727571_1728987_+	Y-family DNA polymerase	M1Q231	Streptococcus_phage	1.7e-200	73.0
WP_166044127.1\|1728988_1729348_+	hypothetical protein	E4ZFJ1	Streptococcus_phage	1.8e-18	48.7
WP_166044129.1\|1729676_1730354_+	methylase	A0A2H4YF91	Aeromonas_phage	1.1e-08	34.0
WP_166044130.1\|1730358_1734768_+	DEAD/DEAH box helicase family protein	A0A1V0SEE0	Indivirus	2.6e-18	22.1
WP_039698258.1\|1734910_1735330_+	DUF4065 domain-containing protein	A7J2B6	Streptococcus_phage	6.8e-09	29.9

DBSCAN-SWA_9

1810487 : 1819010

Bacillus_virus(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_157629042.1\|1810487_1811408_+	type I pantothenate kinase	A0A1B1ISL9	uncultured_Mediterranean_phage	9.6e-32	31.1
WP_004231769.1\|1811483_1811735_+	30S ribosomal protein S20	NA	NA	NA	NA
WP_039696862.1\|1811819_1813148_-	HAMP domain-containing histidine kinase	Q8QNA2	Ectocarpus_siliculosus_virus	2.5e-09	36.8
WP_074563738.1\|1813137_1813812_-	response regulator transcription factor	W8CYM9	Bacillus_phage	2.2e-25	32.3
WP_157629043.1\|1813978_1816522_-	aminopeptidase	A0A0P0IY26	Acinetobacter_phage	5.1e-67	24.9
WP_039696860.1\|1816752_1817406_-	phosphate signaling complex protein PhoU	NA	NA	NA	NA
WP_039696859.1\|1817436_1818195_-	phosphate ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.2e-18	30.5
WP_166044200.1\|1818206_1819010_-	phosphate ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.4e-15	28.0

DBSCAN-SWA_10

1935326 : 1947752

Bacillus_phage(33.33%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_166044310.1\|1935326_1935737_-	peptide deformylase	A0A2I7QLT9	Vibrio_phage	9.9e-13	40.7
WP_093814675.1\|1935733_1936243_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_074626687.1\|1936399_1937749_-	NADP-specific glutamate dehydrogenase	NA	NA	NA	NA
WP_039696754.1\|1937984_1938482_+	membrane protein	NA	NA	NA	NA
WP_074626685.1\|1938518_1939010_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	7.4e-47	62.3
WP_074626684.1\|1939158_1939872_-	7-carboxy-7-deazaguanine synthase QueE	E7DN68	Pneumococcus_phage	3.4e-61	46.1
WP_074626682.1\|1939864_1940311_-	6-carboxytetrahydropterin synthase QueD	J9PV91	Bacillus_phage	6.9e-44	56.3
WP_074626680.1\|1940310_1940961_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	1.2e-60	54.5
WP_166044312.1\|1941127_1942897_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	7.5e-57	30.1
WP_166044314.1\|1942899_1944639_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	2.9e-37	24.7
WP_074626674.1\|1944681_1946550_-	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	1.1e-66	33.2
WP_074626672.1\|1946546_1947752_-\|tRNA	CCA tRNA nucleotidyltransferase	H7BUW3	unidentified_phage	2.1e-42	48.0

Anti-CRISPR protein detection

Acr_ID: NZ_CP046919.1|WP_009853863.1|243024_243351_+|RepA-family-replication-initiation-factor

Click the colored protein region to show detailed information

Acr_ID: NZ_CP046919.1|WP_166042949.1|147487_147628_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_CP046919.1|WP_009853863.1|243024_243351_+|RepA-family-replication-initiation-factor

243024_243351_+

108 aa aa

hit_Aca_id	identity	query_coverage	hit_coverage
gnl\|BL_ORD_ID\|63	0.7685185185185185	1	1.0

NZ_CP046919.1|WP_166042949.1|147487_147628_-|hypothetical-protein

147487_147628_-

46 aa aa

133178-241952

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP046919_1	TypeII	1.6\|116398\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116398-116427	30	211964-211993	0
NZ_CP046919_1	TypeII	1.8\|116530\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116530-116559	30	209276-209305	0
NZ_CP046919_1	TypeII	1.10\|116662\|30\|NZ_CP046919\|CRISPRCasFinder,CRT,PILER-CR	116662-116691	30	211640-211669	1

1. spacer 1.6|116398|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP046919 position: 211964-211993, mismatch: 0

tcgattaggtagacgtcttcttgtgtaggg	CRISPR spacer
tcgattaggtagacgtcttcttgtgtaggg	Protospacer
******************************

2. spacer 1.8|116530|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP046919 position: 209276-209305, mismatch: 0

taattctcgtcatcaaggtcgagaatggca	CRISPR spacer
taattctcgtcatcaaggtcgagaatggca	Protospacer
******************************

3. spacer 1.10|116662|30|NZ_CP046919|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP046919 position: 211640-211669, mismatch: 1

tttggtgacgctcattgcttacctccttaa	CRISPR spacer
tttagtgacgctcattgcttacctccttaa	Protospacer
***.**************************

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP046920

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP046919

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information