CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP049865	Propioniciclava sp. HDW11 chromosome, complete genome	4 crisprs	DEDDh,csa3,cas3,WYL,RT,DinG	1	1	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP049865_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049865_1

260732-260830

Orphan

Consensus_repeat	Method
GCGGCCTTCTTCGGCTTGGCCTCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049865_1

>merge|NZ_CP049865|1|260732-260830|CRISPRCasFinder
GCGGCCTTCTTGGCCGCGGCCTTCTTCGGCTTGGCCTCGGCGTCGGCCTCGTCGGCCTTGTCGGCCTTCTTGGCGGCGGCCTTCTTCGGCTTGGCCTCG

>NZ_CP049865|1|1|260732-260830|CRISPRCasFinder
GCGGCCTTCTTGGCCGCGGCCTTC	TTCGGCTTGGCCTCGGCGTCGGCCTCGTCGGCCTTGTCGGCCTTCTTGGCG
GCGGCCTTCTTCGGCTTGGCCTCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049865.1\|WP_166231287.1\|269126_269363_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049865.1\|WP_166231269.1\|262736_263564_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|181069
NZ_CP049865.1\|WP_166231249.1\|253171_253972_+\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|372611
NZ_CP049865.1\|WP_166231281.1\|267031_268060_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP049865.1\|WP_166231284.1\|268245_268791_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237868
NZ_CP049865.1\|WP_166231266.1\|262446_262731_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049865.1\|WP_166231255.1\|254834_257432_+\|valine--tRNA-ligase	unknown	unknown	gnl\|CDD\|380147
NZ_CP049865.1\|WP_166231293.1\|270304_271825_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049865.1\|WP_166231246.1\|252609_253161_+\|DoxX-family-membrane-protein	unknown	unknown	gnl\|CDD\|284659
NZ_CP049865.1\|WP_166234868.1\|259957_260608_-\|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl\|CDD\|178955
NZ_CP049865.1\|WP_166231290.1\|269370_270261_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP049865.1\|WP_166231278.1\|266450_267020_-\|dehydratase	unknown	unknown	gnl\|CDD\|239533
NZ_CP049865.1\|WP_166234866.1\|259301_259901_-\|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl\|CDD\|237133
NZ_CP049865.1\|WP_166231257.1\|257428_257908_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379393
NZ_CP049865.1\|WP_166231272.1\|263560_265192_-\|acyl-CoA:acetate/3-ketoacid-CoA-transferase	unknown	unknown	gnl\|CDD\|227016
NZ_CP049865.1\|WP_166231260.1\|257983_259267_-\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpX	unknown	unknown	gnl\|CDD\|235422
NZ_CP049865.1\|WP_166234864.1\|251129_252530_-\|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	unknown	unknown	gnl\|CDD\|223362
NZ_CP049865.1\|WP_166234862.1\|250788_251109_-\|DUF4233-domain-containing-protein	unknown	unknown	gnl\|CDD\|379420
NZ_CP049865.1\|WP_166231252.1\|253983_254733_+\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|372611
NZ_CP049865.1\|WP_166231275.1\|265272_266454_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173838

Protein	Function_ID	Function_description	E-value
NZ_CP049865.1\|WP_166231269.1\|262736_263564_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|181069	PRK07657, PRK07657, enoyl-CoA hydratase; Provisional.	1.08829e-69
NZ_CP049865.1\|WP_166231249.1\|253171_253972_+\|thioredoxin-domain-containing-protein	gnl\|CDD\|372611	pfam13462, Thioredoxin_4, Thioredoxin.	9.76938e-14
NZ_CP049865.1\|WP_166231281.1\|267031_268060_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	4.59269e-90
NZ_CP049865.1\|WP_166231284.1\|268245_268791_+\|hypothetical-protein	gnl\|CDD\|237868	PRK14960, PRK14960, DNA polymerase III subunit gamma/tau.	0.00891518
NZ_CP049865.1\|WP_166231255.1\|254834_257432_+\|valine--tRNA-ligase	gnl\|CDD\|380147	NF000540, alt_ValS, valine--tRNA ligase.	0
NZ_CP049865.1\|WP_166231246.1\|252609_253161_+\|DoxX-family-membrane-protein	gnl\|CDD\|284659	pfam07291, MauE, Methylamine utilisation protein MauE. This family consists of several bacterial methylamine utilisation MauE proteins. Synthesis of enzymes involved in methylamine oxidation via methylamine dehydrogenase (MADH) is encoded by genes present in the mau cluster. MauE and MauD are specifically involved in the processing, transport, and/or maturation of the beta-subunit and that the absence of each of these proteins leads to production of a non-functional beta-subunit which becomes rapidly degraded.	2.50472e-06
NZ_CP049865.1\|WP_166234868.1\|259957_260608_-\|ATP-dependent-Clp-protease-proteolytic-subunit	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	5.44789e-115
NZ_CP049865.1\|WP_166231290.1\|269370_270261_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	3.73474e-37
NZ_CP049865.1\|WP_166231278.1\|266450_267020_-\|dehydratase	gnl\|CDD\|239533	cd03449, R_hydratase, (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase II, and beta-hydroxydecanoyl-ACP dehydratase, MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and the fatty acid synthase beta subunit. The active site lies within a substrate-binding tunnel formed by the (R)-hydratase homodimer. A subset of the bacterial (R)-hydratases contain a C-terminal phosphotransacetylase (PTA) domain.	1.77949e-31
NZ_CP049865.1\|WP_166234866.1\|259301_259901_-\|ATP-dependent-Clp-protease-proteolytic-subunit	gnl\|CDD\|237133	PRK12553, PRK12553, ATP-dependent Clp protease proteolytic subunit; Reviewed.	2.68512e-118
NZ_CP049865.1\|WP_166231257.1\|257428_257908_+\|hypothetical-protein	gnl\|CDD\|379393	pfam13845, Septum_form, Septum formation. This domain is found in a protein which is predicted to play a role in septum formation during cell division.	3.23188e-06
NZ_CP049865.1\|WP_166231272.1\|263560_265192_-\|acyl-CoA:acetate/3-ketoacid-CoA-transferase	gnl\|CDD\|227016	COG4670, COG4670, Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism].	0
NZ_CP049865.1\|WP_166231260.1\|257983_259267_-\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpX	gnl\|CDD\|235422	PRK05342, clpX, ATP-dependent Clp protease ATP-binding subunit ClpX.	0
NZ_CP049865.1\|WP_166234864.1\|251129_252530_-\|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	gnl\|CDD\|223362	COG0285, FolC, Folylpolyglutamate synthase [Coenzyme metabolism].	1.66793e-130
NZ_CP049865.1\|WP_166234862.1\|250788_251109_-\|DUF4233-domain-containing-protein	gnl\|CDD\|379420	pfam14017, DUF4233, Protein of unknown function (DUF4233). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 122 and 147 amino acids in length. Proteins in this family are integral membrane proteins.	3.0938e-09
NZ_CP049865.1\|WP_166231252.1\|253983_254733_+\|thioredoxin-domain-containing-protein	gnl\|CDD\|372611	pfam13462, Thioredoxin_4, Thioredoxin.	3.28628e-10
NZ_CP049865.1\|WP_166231275.1\|265272_266454_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	6.01047e-66

>NZ_CP049865.1|WP_166234868.1|259957_260608_-|ATP-dependent-Clp-protease-proteolytic-subunit
MSPGAGSFGDVNEKLPGISAAVGAGGIGMNDSVYQALLANRIVFLGSEVRDDNANAICAQLLLLNAEDPEKDIYLYINSPGGSVTAGMAIFDTMQWISNDVATVAMGLAASMGQFLLSAGTKGKRYALPHARIMMHQPSGGLGGTASDIKILAEQILATKKEMAELIAEHTGRPVEQIEADSDRDRWFTAPQALEYGFIDHVYTNAAQIADNAPNQ
>NZ_CP049865.1|WP_166234866.1|259301_259901_-|ATP-dependent-Clp-protease-proteolytic-subunit
MDYYIPQWEERTSYGVRRVDPYTKLFEDRIIFLGTPISDDIANAVMAQLLCLQSMDPERPISMYINSPGGSFTALTAIYDTMQYIKPDVSTVCLGQAASAAAVLLAAGTKGKRYALPNSRILIHQPATEGGYGQGSDLEIQAREILRIRSLMEHMLAKDTGQSVEQVSRDIERDKFLTAEEAKEYGIIDEIFTSLKDVA
>NZ_CP049865.1|WP_166231260.1|257983_259267_-|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpX
MARIGETSDLLKCSFCGKSQKQVKKLIAGPGVYICDECIELCNEIIEEEFSEGADVGLLEDLPKPRDIVGHLDQYVIGQETAKKALAVAVYNHYKRVQAQANSPRRAAEDELVELGKSNILLIGPTGCGKTYLAQTLARMLNVPFAMADATALTEAGYVGEDVENILLKLLQAADFDVKKAETGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNILFIVGGAFAGLEDIINARIGKRPLGFNNDLGLRRKDTRNPFEEVRPEDLHTFGLIPEFIGRLPMISTVNPLDLDAMVRILVQPRNALTKQFRKLFELDGVDLEFTDDAVTAIAELALARGIGARGLRSILEEILLNVMYHVPSDDTIGQVVVTAETVREGAEPRMLPRAPRSTRRSRSA
>NZ_CP049865.1|WP_166231257.1|257428_257908_+|hypothetical-protein
MSAARAAAAAVAAALLLGGCSVGDRLNTVKQEAGKAVLPSIAIGACTNLDLGTSDVATEVDQIPPVPCDKPHGWEAYAEKQFGIDDAFPGDAVLAGEAEQYCVDSFEGYVGADYDTSSLEMQYLYPTEQSWTRLVDRTITCLVGTPALDLVGSVKGSGK
>NZ_CP049865.1|WP_166231255.1|254834_257432_+|valine--tRNA-ligase
MASTPSADTSTPTSPAWTVPERPALEGLEDRWVASWRDADTYAFTRPERRDQVFSIDTPPPTVSGSLHVGHVFSYTHTDLVARYQRMRGKQVFYPMGWDDNGLPTERRVQNYYGVRCDTSVPYDPDFTPPAKPDPKKQIPISRRNFIELCHELTSVDEKVFEDLWRRLGLSVDWNTLYATISDEAQRVAQLAFVRNLARGEAYLSEAPTMWDVTFQTAVAQAELEAREYPGNYYRVAFHAADGPIHIETTRPELIPSVCALIAHPDDERYAHLFGTTVTSPVFGVEIPVLAHAAAEKDKGAGIAMCCTFGDLTDVQWWRELQLPTRVVLQRNGRLQPEAPDWLVNAEPYAELANKTTFSAREAMVGLLRAAGDLDGEPRPTQRMANFYEKGDKPLEIVSTRQWYLTNGGRDAGLRATLLERGQELAWVPEYMRHRYTNWVDGLNGDWLISRQRFFGVPFPIWYPLDAEGEPDHDHPIVADEASLPVDPTSEPAPGYEESQRGVPGGFVADPDVMDTWATSSLSPQIVCGWERDEELWNLTFPMDLAPQAHDIIRTWLFSRVVRAQLENHSLPWVRAAISGFVVDPDRKKMSKSKGNVVVPTDVLDKFGADAVRWRAAMARPGLDSPFDETQMKVGRRLAMKILNASKFVLGIASEGGTVPQASAIGAPVDLAMLAALRQVVDQATAAFEAFDYTSALEAAEKFFWTFCDDYLELVKERAYGAQGEAAAASARAALATALGVQLRLFAPFMPFVTEEVWSWWQDGSVHHAPWPEASEIFGDGDPRLLDDVSAVLIGLRGAKSAAKVSMKTPLSSATVQGPADQVERLQAVEDDLRAVGRVEASVDWVPGGDALSVAAIVAPSEAQA
>NZ_CP049865.1|WP_166231252.1|253983_254733_+|thioredoxin-domain-containing-protein
MASSASRRDQLRRQQQEAAARQKRTTRIIGVAVGLLAAVLVGVLVFALVNAPQAPAPTPRAEQVTPPSANADASALVLGRGAPGSPTVTVYLDYQCPNCRIFEEVYGPMLQREAAAGTWTLQNSTMTFLEQALSNTASTRAAVAAACSAFADRYADFNAAIFSHQPANEVRGAVGYTDELLRATIPADLGFTAEQTTALQACYDGRATEDFVAGVDKAAYASGVSATPTLTVDGRPIDLSKARDGSPTR
>NZ_CP049865.1|WP_166231249.1|253171_253972_+|thioredoxin-domain-containing-protein
MASNATNRRDQLRRQQEAAARQSRTTRIIGVAAGVLALVLIGVLVYAFVSQQPKGGETGGPGTTPLAAQIVPPNANADKDGLIVAQGAAGTPTVTMYLDYQCPNCRTFELGYGQMLDDEAKAGTWTLENKTMVFMDNNLQNTASTRAALAASCAATVDHYKEYSLEVYNNQALQEVRGSDGYSDQLLRETIPAKVGIAGDQLSTFQACYDGRATQDFVAAVDKAAYADGVTGTPSMAVNGKLLNLSLLKDTSPAGLKAFILANTGA
>NZ_CP049865.1|WP_166231246.1|252609_253161_+|DoxX-family-membrane-protein
MTAAHTPVRSAWMGWVGLLARLVLGGVLLVAGALKVGAIGESILAVRAYRLLPYELTTVVGTVLPFAEVLLGLLLITGTFTRISGVLGALLMVAFIIGIGSAWARGLTLDCGCFGGGGEISAEEAFAAYPWEIARDVGLAACGAWLALWPRTPFSLDNWIFGAPGATPADTADADTEPLTTGN
>NZ_CP049865.1|WP_166234864.1|251129_252530_-|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase
MMTHADIVASLQSRWPEHRVAPSLSRIAALTELLGDPQRSYPVIQVAGTNGKGSTAIMIESILLAMNLRVGRVSSPHLSDLTERISIDGEPISHEAFDALVGDVMPLVSIVDEQRLDGVGMTFFEVMTGLAYEAFAQAPVDVAVIEVGLGGTWDATSVADAEVAVVCPVDLDHTHLLGDTIAEIAGEKAGIIKEGSVAVLAEQHPDAARVLMERCREVGARMVREGVEFGLIGRTPAVGGQVLRLETADGPVDDLLLPVFGEHMAHNAALAVAAVEAFLGGKPVPSDVLAEGLGAVRLPARLEVVRTDPTVVLDTCHNVHGATATMAGMAEAFDFTPLIAVVGMMADKDIEGVLRVLEDGVTTIVCTQVASTDRGLPAEELGEVASDVFGAERVHVRDSLPDALELAVTLADQAGAGAGILVAGSVVLAGEARTLLVRQAADRDSDDVLGEADGYDPDHLQDEDDD
>NZ_CP049865.1|WP_166234862.1|250788_251109_-|DUF4233-domain-containing-protein
MNRAISLALIFEVVVFVLAIPGMIQVDDVPIGLAMGAGGAAALVPLLAAALLRRPVGWVFAWLAQAAGLALGLLTPWMYVVGGAFALLFVVSFVLGRRIEQSTPRS
>NZ_CP049865.1|WP_166231266.1|262446_262731_-|hypothetical-protein
MSPSVPVPHSRPRVGVRLDAAGGPLVRRWLLQLGADPVDAAAPGADGLPLAPQHDGVRREDVAAFVHGLRGIERRRAERFDDHGSEQSWPRGSY
>NZ_CP049865.1|WP_166231269.1|262736_263564_-|enoyl-CoA-hydratase/isomerase-family-protein
MSDPAEGTVGLHVEDGIARLHLDRPAKLNAFTLAMLARLEDHLDALERSEDVRVVIVTSAGERVFSAGADIHHFRRLTALQMWSTWTRTGHRVFDRLARLRQPTIAAMDGDAFGGGLEIALACDLRVLADDAQVGLTEVAIGTVPGWGGLDRLPALVGPARAKRMVFTGTPIDAATALDWGLVTDVAPRADVVDAALALAAVVADRSPLAVQMSKQAIDAGAGLGLGMALEGLASAASGASDDFSEGVTAFRHKRTPAFTGSLGTPGPRTAHLDD
>NZ_CP049865.1|WP_166231272.1|263560_265192_-|acyl-CoA:acetate/3-ketoacid-CoA-transferase
MRTPPVLTAREAAELVGDGATVSVSSASAIGVPDALLAGIGQRFEETAHPAGITSLHCINSGEMSSGIAGVDHLAKPGLLRRILGGSFPAGPATMDAPPVRRMIAAGQVEAYNIPSGIMYQMHRAAALRQPGVLTQSGLGTYADPRVEGAKMNAAAPDFVRLEQFDGQEWLFYPAVPVDVALIRATTADPRGNLTFEEEASPLGALDIAYAARNSGGVVIAQVKRLTDVPHHPREVLVPGILVDAVVVAPDQVQTGLAEYDPAISGNELRDLDAIEPLEFSLEKVICRRAAMELARNDVVNLGFGISAGVPRVLLEEGIFDQVTWVIEQGPVGGFPLTGFQFGAAINPDAIVRSSDQFTLLQGGGFDAGLLSFMEVSSAGDVNVSLLKARPHATAGIGGFADITGFAPNLVFSGQFTAGRKDVTLGEGRLAINEDGAIAKFVPDVAQISFAGALAAERGQKVRYVTERCVLELRDAGLTVIEIAPGVRLQEDVLDRSAIPLAVADDLVEMDARIFTDAPMGLTLAEPRRPLPDQQELRERVQR
>NZ_CP049865.1|WP_166231275.1|265272_266454_-|acyl-CoA-dehydrogenase
MTDLLARLDDLIETTLIARAPQIDETAEFPVDITRAAAAIGVQRLLLAEDGALDVARTPLVVETSERIAMHSMASAVTIANGRLTTYLLLKYAPQHLVERWVEPTLRAEAFGAFGITEAHAGSDVRAIATVARRDGGDLVLTGEKRWVGYAPNGQYAIVLAKLDDDARDARTVAVVVDTASAGVTQEHGPAFSGLRGMPNGVLRLDAVRVPATDVLAVDGFGGMMDGLNLARIDAAAYACGLLRGALTASVERAATRRAFGKVLGDLPSIQAKIGRMAAAYQAARALTDRAAASFARGDGGDQDVISMAKLFTSDAAREHTDEAVQIHGAEGMVASSWVNRLNRDAKVTQIFDGTSEIHETMLGRRAVRAHQRGEAMDAFLGRGGATSAAPQE
>NZ_CP049865.1|WP_166231278.1|266450_267020_-|dehydratase
METYLPLHSRSIYCGAHPAHAEVVGDPGGTHVPPAKRTPHRTEPGPGGPVSQYPEVGARARFAKTVTETDVTLFAGITGDLAPQHTNAAYMAAHPVGQRVAHGVLTLGVASTASSALCAEHGVTALSYGYDKVRFLAPVFLGDTVSVELTVARIEPARSIAVADVRVTNQRGDLILVAEHLLYCYEETR
>NZ_CP049865.1|WP_166231281.1|267031_268060_+|LacI-family-transcriptional-regulator
MTRVTLNDVSRAAGVSRATASLVVRGSDRISPATTARVRAAMEQLGYVYDRGAAQLRGGRTMTVGVIVPEIRNPYLADLLMTIEQSLSAHGYTSLIAHSGESVRRESEILATMTERRVDGVLVHPSRTLDDAPLDEHTSRFDIPVVTMMRRLEDRFSSVTPDNERAGVLMGEHLRTLGVRSVTFLGGPAHSSGRADRIAGMRTSLGESIAFEHGEQTTTATTYSDAGRTAMAQIFERGELPDAVVGFSDIVTMGLYAELHQRGLLPGRDVAVASFDDISMASWLTPPLTSMAAGADQVGVAASEEILAAIEQGPAHTPTRRLIPPELRLRTSTLGWRPRPTA
>NZ_CP049865.1|WP_166231284.1|268245_268791_+|hypothetical-protein
MKDEPQEVPFLEVRGKVPCPDNPDLELQSGGWRNHGRFDSLAYDLVIVDRDQPVHPSGDGDEAGATVASAEGGEAAKDLVTAGLVVIGLGTAWAVGRYGPSAIAWAQREVLPRAQDLWTNACSVQPFRRWSTLGRRQALPLQLEPGLTSPEPLPWAAIEPELEPASDPNPPNPEAGPQPAP
>NZ_CP049865.1|WP_166231287.1|269126_269363_+|hypothetical-protein
MPGIEVVLAALVVIAVIGQLERTERRMRALPRAPLGADEDSLAIAEYRRELRELREVAQRADQRARTGERFNAALRHL
>NZ_CP049865.1|WP_166231290.1|269370_270261_+|LysR-family-transcriptional-regulator
MIDVSRLRVFRAVVAAGSIQAAAASLGYTPSAVSQQVAALSRETGLPLLQRVGRGVEPTAAGLHLAEASAPLFAELAEVESAAEDLRTGRVGSLSMAYFTSAAMAWIPGVVADVLAHHPDLRLDLRVLELPTGEDDHVDVEVLVSDGALDPAPGFRAVPLLTEPYVVVLPRTHRLAGSDQVEVAELAGERWIAHDSADSWCRRLTERACVSAGFVPQYSVYTHGHTTAIAFVAAGIGVAAMPLLCVRELPPDAVAVPLIHPTPERTIHLMVRRSVEHTAPVRRALAGLVAAAAAHP
>NZ_CP049865.1|WP_166231293.1|270304_271825_-|hypothetical-protein
MRTSVRRALVGFGMAGLLATMTPTAAAAGPAWGDAADTMTAVPAVTHVPREGGSYPFNAADHHRVPVDLAAHGFVEEEFFLTGHANVYTRADGTLAVHRTAVPYTNRILVRHPARAQKASGTVLVDIYNASNGYDIEDMWRRLWTDVLEQGHTYIGVTSKPVNVDALHTFDPQRYAPVSWYDEPLTAACAYTFTAAGDDVPCTETGLVWDILTQVGNAVRDPQAGRQILGGIKPTGVFLIGQSQSGLYLNTYVNHFHNPVTAAHAGQHVFDGYLTAAGNWNERAIRDGEPTGQGAPAASVPVDIDVPWIFVDSESDTALFQREATMPRPLDDQTRVWQVSGTGHTYSMSPVVPDNAELRKAGRPERVFPTVYTPYPMEPAMIAATQALIDNHRSGKELPASKWFQRDAAGALVRDDHGNVLGGLRYGLMELPLAQFLGFARPFDMNGVAHPISKAEFERNWRNRSQYLAQMRAHDNKLRQAGYLTKSGHATFAERAEVVMDRIGVR

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Crispr_ID: NZ_CP049865_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049865_2

672580-672674

Orphan

Consensus_repeat	Method
GCAGCCCGGCCAGTCAGTGCGGGGAACGCCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049865_2

>merge|NZ_CP049865|2|672580-672674|CRISPRCasFinder
GCAGCCCGGCCAGTCAGTGCGGGGAACGCCGCCCGCACCGACCCAGCCGCCACTCCACGGGAGCAGCCCGGCCAGTCAGTTCGGGGAACGCCGCC

>NZ_CP049865|2|2|672580-672674|CRISPRCasFinder
GCAGCCCGGCCAGTCAGTGCGGGGAACGCCGCC	CGCACCGACCCAGCCGCCACTCCACGGGA
GCAGCCCGGCCAGTCAGTTCGGGGAACGCCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049865.1\|WP_166231927.1\|655294_656224_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|379770
NZ_CP049865.1\|WP_166234923.1\|682223_683027_-\|NADH-quinone-oxidoreductase-subunit-J	unknown	unknown	gnl\|CDD\|235844
NZ_CP049865.1\|WP_166231943.1\|675911_676961_-\|polyprenyl-synthetase-family-protein	unknown	unknown	gnl\|CDD\|223220
NZ_CP049865.1\|WP_166231944.1\|676894_678475_-\|NADH-quinone-oxidoreductase-subunit-NuoN	unknown	unknown	gnl\|CDD\|235603
NZ_CP049865.1\|WP_166231940.1\|666060_670398_+\|activase	unknown	unknown	gnl\|CDD\|226108
NZ_CP049865.1\|WP_166231933.1\|658137_658692_+\|NADH-quinone-oxidoreductase-subunit-C	unknown	unknown	gnl\|CDD\|376317
NZ_CP049865.1\|WP_166231935.1\|658688_659015_+\|4Fe-4S-binding-protein	unknown	unknown	gnl\|CDD\|224066
NZ_CP049865.1\|WP_166231941.1\|673261_673522_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049865.1\|WP_166231925.1\|654469_655291_+\|exodeoxyribonuclease-III	unknown	unknown	gnl\|CDD\|197336
NZ_CP049865.1\|WP_166231923.1\|653382_654303_-\|high-affinity-Fe2+/Pb2+-permease	unknown	unknown	gnl\|CDD\|251822
NZ_CP049865.1\|WP_166231946.1\|683032_683593_-\|NADH-quinone-oxidoreductase-subunit-NuoI	unknown	unknown	gnl\|CDD\|235637
NZ_CP049865.1\|WP_166231931.1\|657761_658145_+\|proton-conducting-membrane-transporter	unknown	unknown	gnl\|CDD\|235797
NZ_CP049865.1\|WP_166231937.1\|660952_661984_+\|2-oxoacid:ferredoxin-oxidoreductase-subunit-beta	unknown	unknown	gnl\|CDD\|237006
NZ_CP049865.1\|WP_166231929.1\|656248_657694_-\|polyprenol-phosphomannose-dependent-alpha-1,6-mannosyltransferase-MptB	unknown	unknown	gnl\|CDD\|274589
NZ_CP049865.1\|WP_166231939.1\|665392_665977_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP049865.1\|WP_166234921.1\|681921_682221_-\|NADH-quinone-oxidoreductase-subunit-NuoK	unknown	unknown	gnl\|CDD\|180218
NZ_CP049865.1\|WP_166234925.1\|683592_684912_-\|NADH-quinone-oxidoreductase-subunit-NuoH	unknown	unknown	gnl\|CDD\|235692
NZ_CP049865.1\|WP_166231942.1\|673482_674625_+\|DUF222-domain-containing-protein	unknown	unknown	gnl\|CDD\|367155
NZ_CP049865.1\|WP_166231945.1\|678475_679987_-\|NADH-quinone-oxidoreductase-subunit-M	unknown	unknown	gnl\|CDD\|235622
NZ_CP049865.1\|WP_166234919.1\|680000_681908_-\|NADH-quinone-oxidoreductase-subunit-L	unknown	unknown	gnl\|CDD\|235836

Protein	Function_ID	Function_description	E-value
NZ_CP049865.1\|WP_166231927.1\|655294_656224_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|379770	pfam16113, ECH_2, Enoyl-CoA hydratase/isomerase. This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.	3.59382e-128
NZ_CP049865.1\|WP_166231943.1\|675911_676961_-\|polyprenyl-synthetase-family-protein	gnl\|CDD\|223220	COG0142, IspA, Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism].	3.1137e-83
NZ_CP049865.1\|WP_166231944.1\|676894_678475_-\|NADH-quinone-oxidoreductase-subunit-NuoN	gnl\|CDD\|235603	PRK05777, PRK05777, NADH-quinone oxidoreductase subunit NuoN.	4.43629e-164
NZ_CP049865.1\|WP_166231940.1\|666060_670398_+\|activase	gnl\|CDD\|226108	COG3580, COG3580, Uncharacterized protein conserved in bacteria [Function unknown].	3.76117e-139
NZ_CP049865.1\|WP_166231933.1\|658137_658692_+\|NADH-quinone-oxidoreductase-subunit-C	gnl\|CDD\|376317	pfam00329, Complex1_30kDa, Respiratory-chain NADH dehydrogenase, 30 Kd subunit.	5.2494e-26
NZ_CP049865.1\|WP_166231935.1\|658688_659015_+\|4Fe-4S-binding-protein	gnl\|CDD\|224066	COG1143, NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion].	2.91254e-11
NZ_CP049865.1\|WP_166234923.1\|682223_683027_-\|NADH-quinone-oxidoreductase-subunit-J	gnl\|CDD\|235844	PRK06638, PRK06638, NADH-quinone oxidoreductase subunit J.	7.244e-56
NZ_CP049865.1\|WP_166231925.1\|654469_655291_+\|exodeoxyribonuclease-III	gnl\|CDD\|197336	cd10281, Nape_like_AP-endo, Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases. This subfamily includes Neisseria meningitides Nape and related proteins. These are Escherichia coli exonuclease III (ExoIII)-like AP endonucleases and belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiences. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity; for example, Neisseria meningitides Nape and NExo. Nape, found in this subfamily, is the dominant AP endonuclease. It exhibits strong AP endonuclease activity, and also exhibits 3'-5'exonuclease and 3'-deoxyribose phosphodiesterase activities.	4.23526e-100
NZ_CP049865.1\|WP_166231923.1\|653382_654303_-\|high-affinity-Fe2+/Pb2+-permease	gnl\|CDD\|251822	pfam03239, FTR1, Iron permease FTR1 family.	1.06266e-44
NZ_CP049865.1\|WP_166231946.1\|683032_683593_-\|NADH-quinone-oxidoreductase-subunit-NuoI	gnl\|CDD\|235637	PRK05888, PRK05888, NADH-quinone oxidoreductase subunit NuoI.	2.84792e-73
NZ_CP049865.1\|WP_166231931.1\|657761_658145_+\|proton-conducting-membrane-transporter	gnl\|CDD\|235797	PRK06411, PRK06411, NADH-quinone oxidoreductase subunit NuoB.	6.60669e-27
NZ_CP049865.1\|WP_166231937.1\|660952_661984_+\|2-oxoacid:ferredoxin-oxidoreductase-subunit-beta	gnl\|CDD\|237006	PRK11867, PRK11867, 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed.	4.23302e-165
NZ_CP049865.1\|WP_166231929.1\|656248_657694_-\|polyprenol-phosphomannose-dependent-alpha-1,6-mannosyltransferase-MptB	gnl\|CDD\|274589	TIGR03459, crt_membr, carotene biosynthesis associated membrane protein. This model represents a family of hydrophobic and presumed membrane proteins found in the Actinobacteria. The genes encoding these proteins are syntenically associated with (found proximal to) genes of carotene biosynthesis ususally including phytoene synthase (crtB), phytoene dehydrogenase (crtI) and geranylgeranyl pyrophosphate synthase (ispA).	1.18004e-48
NZ_CP049865.1\|WP_166231939.1\|665392_665977_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.74452e-07
NZ_CP049865.1\|WP_166234921.1\|681921_682221_-\|NADH-quinone-oxidoreductase-subunit-NuoK	gnl\|CDD\|180218	PRK05715, PRK05715, NADH-quinone oxidoreductase subunit NuoK.	4.23359e-40
NZ_CP049865.1\|WP_166234925.1\|683592_684912_-\|NADH-quinone-oxidoreductase-subunit-NuoH	gnl\|CDD\|235692	PRK06076, PRK06076, NADH-quinone oxidoreductase subunit NuoH.	2.90426e-137
NZ_CP049865.1\|WP_166231942.1\|673482_674625_+\|DUF222-domain-containing-protein	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	1.11446e-17
NZ_CP049865.1\|WP_166231945.1\|678475_679987_-\|NADH-quinone-oxidoreductase-subunit-M	gnl\|CDD\|235622	PRK05846, PRK05846, NADH:ubiquinone oxidoreductase subunit M; Reviewed.	1.69769e-166
NZ_CP049865.1\|WP_166234919.1\|680000_681908_-\|NADH-quinone-oxidoreductase-subunit-L	gnl\|CDD\|235836	PRK06590, PRK06590, NADH:ubiquinone oxidoreductase subunit L; Reviewed.	0

>NZ_CP049865.1|WP_166231940.1|666060_670398_+|activase
MEQQPLTLGLDIGSTTVKAVLLDADHVVYSDYRRHNADARGEVRRLIAEIAERWSQITVRAAVTGSGGLHVADLLGVDFVQEVIAGTEAVERFHPEADVVIELGGEDAKITYLKPSPEQRMNGTCAGGTGAFIDQMATLLRTDAAGLNELAARHTTLYPIASRCGVFAKSDVQPLLNQGAAHADIAASVFQAVATQTISGLACGRPIRGNLVFLGGPLHFLPELREAYRRTLAEQVDSFTTPPDAQLYVARGAALLAGGEAKPLSALLAGLDAGASSSVGHTATLRPLFADAAERAAFEARHAAATVPQGRLEDARGPLFLGLDAGSTTIKCVVMDASGTIVHSHYAGNGGNPVAAAIDIVREVRERLPAEAELARCCVTGYGEGLVQAALRIDQGEIETMAHYRAADRLSPGVTSVIDIGGQDMKYLRVRGGALDSIAVNEACSSGCGSFLQTFAETMGTDVRAFAASALAAQQPVDLGSRCTVFMNSSVKQAQKEGASVGDIAAGLSYSVVRNALYKVIKLRDADALGERVVVQGGTFLNDAVLRAFELLTGREVVRPDVAGLMGAYGAALTAQRAWEPGTVTSLLELDELDDFAVETTRRTCKLCQNHCGLTISSFPDGSRHVSGNRCERGASLEDKPQRTEIPNLHDFKYRRLFAYRRLTDAQATRGAIGIPRVLNMYENYPLWFTILTALGYKVMLSGRSNHDLFADGMETIPSENVCYPAKLAHGHIEWLLDRGVTTIFYPCVSLEQPAFEASDHNFNCPVVAFYPQVLAKNIDRLREPGVKLLDPFVNLADPDKLAQRLAEVFEGDGVTLEEARAAVEAGYAEDAAYKADVLAEGRRALEYAAEHGRKGIVLAGRPYHVDPEIHHGIPEMINQLGMVVLTEDAVADAPRLERPLRVRDQWTYHSRLYEAAARVRTEPELQLVQLNSFGCGLDAVTTDQVQEILETAGDVYTVLKIDEVSNLGAATIRLRSLKAATAERRPRSAEVVTYDAAAKEGLGHPVFTKDARRTHTIYAPQMAPIHFRLIVPVLRKVGYDVKLLEHASRDDVEVGLRYVNNDVCYPAIMVVGQLINAFIAGGADPDNSSVIITQTGGMCRATNYAGMLRKGLADAGFAQVPVLAISAQGLEESPGFKLTPALLHRAIQAIVVGDVLQNVLLRTRPYEAEVGAADALYRHWDAVASEFFTTGGWSATLKRRVSYRWLIERIVRDFDRLPLADVPRRPRVGLVGEILVKFSPDANNDAVRVIESEGCEAVLPDLLPFFMMSMHTAGWKLDHLGVGTPRGVRLQQGAAWLIEQYQRPARRALAAATRDFVVAQPLTEVARRAESIVSLGTTAGEGWLLVGEMMELIEDGCPNIVVAQPFACLPNHVVGKGVFRELRRLYPEANVVAIDYDPGASEVNQLNRIKLMVATAHKNAGRIQAEKLGPRPLSITPVSSTLGV
>NZ_CP049865.1|WP_166231939.1|665392_665977_-|TetR/AcrR-family-transcriptional-regulator
MRASKRDHIVDAATALIRRDGVRAASIAKIIAASESSAGSVYHHFANKNEIVLAVARKALVEPLEATLAAQEGQALSPGTLLRLLSGAVVDGTVDSSLIVQLWAGAADEPQLGLIVREQMEGVRRRATAGLVTYLREQGVADAELRANLLAVLTMGQMMGLLAQRTMIPDFDQVAYLQAASRMLDAAALGRLPA
>NZ_CP049865.1|WP_166231937.1|660952_661984_+|2-oxoacid:ferredoxin-oxidoreductase-subunit-beta
MMSTGLAGVPLSLTPLNRKEFVSDQEVRWCPGCGDYAVLAAFQSLMPQLGVRRENTVIVSGIGCSSRFPYYLDTYGLHSIHGRAPAIATGVAMSRPDLAVWVVTGDGDALSIGGNHLIHALRRNVNITIMLFNNRIYGLTKGQFSPTSETGKVTKSSPAGSVDHPFNPLTLALGADATFVARAIDSDRKNLTDVLTAAVNHRGASIVEIYQNCPIFNDDAFEGLKSPDSPAVIPLVHGEPITFAGGELGVVRKPDGSLGITAVSDVDPADLLVHDAHNPDATQAFQLSQLTDTQGLSVSPIGILRDVDRPVFDDEARKQVHMPADRTAELAKLVAGPDTWTVL
>NZ_CP049865.1|WP_166231935.1|658688_659015_+|4Fe-4S-binding-protein
MTHRSIALIADRCTSCMICARECPTWCISLASHSEPLPDSPPGPRQRTRLVLDAFAIDWSLCLYCGICIEECPFDALEWRDAPPPASTSVAAMAPDLMPDAAQRTPAG
>NZ_CP049865.1|WP_166231933.1|658137_658692_+|NADH-quinone-oxidoreductase-subunit-C
MPDAVRRVPPQEWRAAVAAALASGNTWFDWLGATDEIGREDAFRVLIRLAPTPDADGVRLETLTAGREDPHLPSLRDLIAGAAWHEREVRDFFGITFDGGDNRPLLLRPDAVGHPLRRDAVLAARVARPWPGGKEPGEAASAARRRMVPPGVPDPDVWGEREGEPAAPEEVAASLQGGRVRRRR
>NZ_CP049865.1|WP_166231931.1|657761_658145_+|proton-conducting-membrane-transporter
MRYYDWFGDGVLTVGVIPLACCVLEVEAAVAGRAALPEPPPGSAVVLLVAGTVTDAVAPAVAAAVAAHPGARVVAFGACASAGGPYWDSPVVTKGVDQLVAVDRYVPGCPPTPEALELLLTRGYADA
>NZ_CP049865.1|WP_166231929.1|656248_657694_-|polyprenol-phosphomannose-dependent-alpha-1,6-mannosyltransferase-MptB
MVSGLAGRWQDLLAAIRLGPVRLGLLGTVLLVLGSLSPAYLPQASPYWPVMRALGLDNEVARVAATALVIGAVGLLILAWYRLRPAVYADVKPWAILCWWALPLLIAPPIFSHDAYSYAAQGWLIQNNLNPYEVSPSVLPGTFADQVAWLWRYTPAPYGPLALTMAHWLDMLAGFNPYYSAVAQRIPALVGVALLVHFLPRIARQLGLDPRQTAWFSTINPLLVIDLIGGAHNDALMLGLVALAVWLAYRGWYWPAVVAVGVGMAVKQPALLAAVPVAVIGSNWESWRWRDLVRFLPRALVTLVGVLIIFAAISLATGLGFGWLNAVGVPGMIVTLAPFSILGWLAEQGFTLLGMEAVGAAAPPLLQSVSLAIAIGLMGWLGIKYARTEPITFLAWAYLAFAVFGPALHTWYLLWGALFLPLARVSDRVLRTAAAVTSVLLVYGAGNLAWRNASIALALAAVAAAAIWLVLRRRARANAIV
>NZ_CP049865.1|WP_166231927.1|655294_656224_-|enoyl-CoA-hydratase/isomerase-family-protein
MSEAELLTEVRDGVGYLTLNRPRAINALTVAMMHGMRDTLAAWADDDAVTSVELSGAGERGLCAGADVRALRDAVLQGRDYGEFFDLEYGLDLMIADYPKPYVAHQRGITMGGGLGVSAHGSRRIAYPDTAFAMPETIIGFTPDVGIAWFLAHAPGQTGTHVALTGATVGARDGVALGLADEVEGDAAPGTLEADREWIDACYAFEDAAQVIAALENHPDPRARAAGADLRLRSPLSVAVTLEALRRVPGMTGVADVLDQDRRLAEHMIGSPDFAEGVRAQLVDKDKRPRWSHARIEDVTRAEVEACFR
>NZ_CP049865.1|WP_166231925.1|654469_655291_+|exodeoxyribonuclease-III
MLRIASFNVNGIRAAQRRGIDAWLDDARPDIVAVQEMRSPAAAVPEKVFGDHHLCYHEGNLAGRNGVALASRVPPSAVRHGFGHRASDAEGRYIEADYEVDGFGVTVGSVYVPKGATWAGPDADPAKYRRKMRFLASFRAYLTRARRDAARAGREFLVMGDFNIAHTTADLKAWRTNQRSEGFLPEERAWFTSILGPRTLVDVVRGLHPDAEGPYSWWSWRGQSFTNDAGWRIDYHLASPGLAARAVAGGTHRAPTYEARISDHAPVVVDYEV
>NZ_CP049865.1|WP_166231923.1|653382_654303_-|high-affinity-Fe2+/Pb2+-permease
MLGAFLIGLREGLEAALVVGILVSYLTKLGRRDVLPRLWLGIGLAVALAVAVGAVLTFGAYALTTQAQEIIGGVLSLLAVGLVTWMIFWMQKAARNLKRTLEGELDKALALGSLWGIVIVGFVSVAREGIETALLLWSMVESAGAAPQALAGALLGLAISVCLGWLIARGMVRLNLGTFFTWTGGLLIVVAAGVLAYGLHDLQEAGVLPGPFSALATLDPATGAVGIGAAGFPFGYAFDVSATVAPGGTLATLLQATVGFMPAMTWVQVLGWALYLAVVGGRFLSRVQRRPRPAPQPSPSLAQGAS
>NZ_CP049865.1|WP_166231941.1|673261_673522_+|hypothetical-protein
METLIRTQSEAFLANVLTGLDDLDPNGLDRTLLTDAERVTLAEQALSAAGRLQALAGVLVAEADRVAAPQTVVGWAHCRGCTTPSG
>NZ_CP049865.1|WP_166231942.1|673482_674625_+|DUF222-domain-containing-protein
MGTLSWLHDAQRMTRREAGRLLAGAQELASRPVLREATLTGAATPLQARAVARVLAQLPEDLPDQKVREAETMMVGFCAQFDSHELGRLARHLLEVIAPEVAEESLERRLEREARHAQAVRHLSFTPDGMGSVLIKGSLPTVEAELLRAQVEAIAHLHHRRALDCADPLVEKATPTQRRADALVELARAAAVHQDAPNHGGDRPRIMVLIDHDRLVDDCRRAQLLDSGADLTPTQLRVLACDAGILPVVMNGAGEVLDVGRANRLVTPAIRAALVARDRGCVFPGCDRTAAACDAHHITPWQRGGPTSLPNLVLLCRHHHNTVEPDHRHPDTHWQIRLDHGVPVVIPPTRVDPQQRPRRNHRHRPRSQTADPASGDASGS
>NZ_CP049865.1|WP_166231943.1|675911_676961_-|polyprenyl-synthetase-family-protein
MVGPAARLGHAAGGVRGRLPAVTSLTDQAVDPVFEALVRERLDSIEERLKETARAQTAFTTDAAQHLLSAGGKRFRPLLVVLASQLYPGAEPSAIDRAAIVMELTHVASLYHDDVMDEADMRRGVPSANSRWDNTVAIMVGDFLFARASSTVATLGTEYVMLQAETFARLVQGQIAETRGAGDESDGLDHYLDVIADKTGSLIAASTVFGGMVCGAPADVLDALAAYGEEIGVVFQLSDDLLDIASDASGKVPGTDLREGVPTLPVLMLRASARPGDERLLDLTSRPLDDEDEVAEALAALRAHRVMDEARAEVGRRAEVARGYLSRLPEGPAREALSALCDQVAFRNT
>NZ_CP049865.1|WP_166231944.1|676894_678475_-|NADH-quinone-oxidoreductase-subunit-NuoN
MSSFLMPALEMAAPTLEWRALAPILLVFAAACLGILLEAVLPRPLRFVAQMSLVIATVVASLAFLTINWRGGYAGRLAMGSITLDGPAYFSWAALLVFGALAFLVFGERRLNGGATTFAASAASVPGSVEEAESSAARREHTEVFPLGMFALTGMMVFAASSDLLTLFVALEVLSLPLYLMSGMARRRRLLSQEAALKYFLLGAFASAFMLFGIAMLYVLSGSFDLRVIHAAVADATTGPGLIFIGLAFIAIGLLFKAGVVPFHNWTPDVYMGAPTPVTGFMAICTKLAAVAALMRVFYVALDGMRWTWQPIFALLAILTMVIGIVGALTQTDIKRLLAYSSIAHAGFLLTAVVGANQQVPAGQATSTSAVMFYLAAYGFATVGAFGIVTMVRNAAGEDNNIGAWSGLASKNPWVAGLMALFMLSFAGIPLTGGFIGKWAVFTSAWQGGYWWLVVIAVLSSLVAAYFYLKVIVVMFAREPAKGTFVGQASAWTWIPVIIGAVGTLWLGLLPDSVMQLAAFAGGFLR
>NZ_CP049865.1|WP_166231945.1|678475_679987_-|NADH-quinone-oxidoreductase-subunit-M
MTFPWLTFLGLLPIIGGLVLLLPMGRGAARTLGLVFSLATLATGATVAALYAGGTDLSVAVPWIRAFGAWWALGLDGMGLAMVLLTVILTPVVLLAEWTPPAGRWSAQTFFALVLILEGLSLFVFTATDVLLFYLFFEATLVPVYFLIVGFGGERRGYAAMKFLLFSLAGGLIMLASVVGLFAVGAAQGAPSYLIGDLAALRIDGDLGRWLMLGFLIAFIVKAPMVPLHTWLPDAAAASTPGTATLLVGILDKIGTFGMVRFCLGLFPEASTWIAPFMMVFAIISILWGALAAVGSTNMMRLVSYTSVSHFGFMVLGIYAFTSQSQTGSIFYMLNHGFSTAALFLAVGFLAKRRGSYDINAFGGVQKVAPVAAGVLLVACLSALSLPGLSTFVSEFLVIAGTWARNPLVVVFALPGVVLAAVYSLAVLYQRPMTGPLTEQSETAFTGRDLNGVERFVMVPVIGALLFLGFVPQPAVQLVEPTAKATMEYVGVADPAPVVKGAK
>NZ_CP049865.1|WP_166234919.1|680000_681908_-|NADH-quinone-oxidoreductase-subunit-L
MLLETLAEPVAATGMFTLAWTMIAVPLVMAGLLLLAGKLTDRWGHLAATAAVLWSFAIAACLFGEQLMRPAAERAVENHVYTWFTVGPWNFEVTLLIDQLSILFALLITGVGSLIHVYSIGYMAHDDRRRRFFAYLNLFIAAMLILVLANNYIVLFLGWEGVGLASYLLISFWQHKPTAAAAGTKAFVMNRVGDLGLLMAMGTMLAMFGSTSFADVNAGAAQLQPFWATAMGLFLLLAACGKSAQVPLQAWLLDAMEGPTPVSALIHAATMVTAGVYLVVRSHAVFEAAPTAQLAVVVVGTVTLLAGAWIGTSQDDIKKVLAGSTMSQIGYMMLAAGIGPAGYAFAIFHLLTHGFFKANMFLGAGSVMHGMNDDVNMRHYGGLSKAMRVTFLTFAMGYLAIIGFPFFAGYFSKDHIIEAAFADNFFIGLCALIGAGVTAFYMTRLMLMTFFGEKRWLKGVHPHESPKVMTIPLIILALFSIFAGLLMNWWIQTWLEPAVGNHAHEVSLIPTPVGLATLLVVALGVAGAWMVFGRKPIPATAPQTSNPITIAGRNVLFGDQVNNFLFVGPTKVVARTADAADAQGIDKAVDGAGHAFAGLSTQLRRLQTGYTRNYALTMLWGVLIVGAVLILGQLG
>NZ_CP049865.1|WP_166234921.1|681921_682221_-|NADH-quinone-oxidoreductase-subunit-NuoK
MNPENYLILAALLFAIGAVGVLVRRNALIAFLCVELMLNACNLALVAGSHITGGLDGQVASFFVMVVAASEVVVGLAIIVSIYKTRRSTSVDDANLLKL
>NZ_CP049865.1|WP_166234923.1|682223_683027_-|NADH-quinone-oxidoreductase-subunit-J
MLVPLVTGAEVTFWIAAPLAVIGALGLVLTRRAVYAALSMAVSMISLAVLYASLDAPFLAMTQIIVYTGAVMMMFLFVLMMVGVDTPDSAVETLKGQRPLAILAGIGLAGLLIFGIGGAIVNPPATVVEANASFGGNAQGLAQLLFGRYVFVFELSSALLITAAVGAMILAHHQRVTPKKDQRELADERMLAYATRGEHPGTLPNSGVYATTNSIAAPALLPDGTIAQKSISHTLMLRGAVIDPVPLAQVTDETFAAIETVEDEEDE
>NZ_CP049865.1|WP_166231946.1|683032_683593_-|NADH-quinone-oxidoreductase-subunit-NuoI
MGLFDAWAGFGVTFRTIFRKTFTQGYPMPGQEKVTAPRFHGRHQLNRWPDGLEKCVGCELCAWACPADAIYVEGADNTEDDRYSPGERYGRVYQINYLRCILCGLCIEACPTRALTMTNDFKLADTSREAMIYTKDRLLAPLLPGMEEPPHPRRLGPDEKSYFLGLPATGVPDTRTGPADTEEVAS
>NZ_CP049865.1|WP_166234925.1|683592_684912_-|NADH-quinone-oxidoreductase-subunit-NuoH
MNDPWWIVLIKVVGVVVLLLTWTIFNVWYERRLVAKMQHRLGPIMNPIWLGGLGQALGDGLKLMFKEDFAPGMVDRVLFTIAPILAGVCAFGAWSVMPLGGEVNMFGVTTRLQVTDMPVSALLLLAMSSVAVYGFVLAGWSSNSPYSLLGSLRSSAQMISYEISMGLSYVAVFLYAGTMSTSEIVEAQGLPLFGGNPIGLQQWYWLLLAPSFVVYVISMVGETNRAPFDLPECESELVSGHLTEYTGFRYAIFFLAEYINMATVSAVATTLFLGGYKAIWPLSLFIPDTGYWGFLWFFIKVQLLISLFVWLRGTLPRFRYDQFMALGWKWLIPISLAWVMIISLMRGLSNHGYLQGPLLYIIIGVVVLALIAVLFLGGEKKVVEQREEKPFDAFAGGFPVPPMPGQTLPEFAGVVSGSSTTTTEEQGALTSDDERKDDE

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Crispr_ID: NZ_CP049865_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049865_3

1876946-1877051

Orphan

Consensus_repeat	Method
GCAGCTGGACTGATCAGGACGCGGGCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049865_3

>merge|NZ_CP049865|3|1876946-1877051|CRISPRCasFinder
GCAGCTGGACTGATCAGGACGCGGGCGCAGCTGGACTGATCGGGCCCCTGGAGAAGCCACGGGCCTCAGGACGCGGACGCAGCTGGACTGATCAGGACGCGGGCGC

>NZ_CP049865|3|3|1876946-1877051|CRISPRCasFinder
GCAGCTGGACTGATCAGGACGCGGGCGC	AGCTGGACTGATCGGGCCCCTGGAGAAGCCACGGGCCTCAGGACGCGGAC
GCAGCTGGACTGATCAGGACGCGGGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049865.1\|WP_166233462.1\|1883423_1883807_-\|ACT-domain-containing-protein	unknown	unknown	gnl\|CDD\|226130
NZ_CP049865.1\|WP_166233463.1\|1883884_1884385_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049865.1\|WP_166235133.1\|1886590_1888228_+\|precorrin-2-C(20)-methyltransferase	unknown	unknown	gnl\|CDD\|381173
NZ_CP049865.1\|WP_166233464.1\|1884441_1884579_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049865.1\|WP_166233460.1\|1880436_1882500_-\|phosphate-acetyltransferase	unknown	unknown	gnl\|CDD\|235537
NZ_CP049865.1\|WP_166233455.1\|1873292_1875923_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224428
NZ_CP049865.1\|WP_166235129.1\|1868525_1868972_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227933
NZ_CP049865.1\|WP_166233466.1\|1885832_1886498_+\|precorrin-8X-methylmutase	unknown	unknown	gnl\|CDD\|181352
NZ_CP049865.1\|WP_166233451.1\|1867673_1868099_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
NZ_CP049865.1\|WP_166233453.1\|1869144_1869849_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049865.1\|WP_166233454.1\|1870650_1873296_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP049865.1\|WP_166233456.1\|1876077_1876209_+\|NAD(P)-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224170
NZ_CP049865.1\|WP_166233465.1\|1884921_1885836_+\|nitrite-reductase	unknown	unknown	gnl\|CDD\|274131
NZ_CP049865.1\|WP_166233450.1\|1866125_1867214_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|282094
NZ_CP049865.1\|WP_166233448.1\|1864816_1865095_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049865.1\|WP_166233458.1\|1878002_1878779_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223377
NZ_CP049865.1\|WP_166233459.1\|1879118_1880303_-\|acetate-kinase	unknown	unknown	gnl\|CDD\|234680
NZ_CP049865.1\|WP_166233449.1\|1865025_1866138_+\|DUF2029-domain-containing-protein	unknown	unknown	gnl\|CDD\|227937
NZ_CP049865.1\|WP_166233452.1\|1868109_1868520_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319924
NZ_CP049865.1\|WP_166233461.1\|1882638_1883427_-\|deoxyribonuclease-IV	unknown	unknown	gnl\|CDD\|179214

Protein	Function_ID	Function_description	E-value
NZ_CP049865.1\|WP_166233462.1\|1883423_1883807_-\|ACT-domain-containing-protein	gnl\|CDD\|226130	COG3602, COG3602, Uncharacterized protein conserved in bacteria [Function unknown].	3.62174e-33
NZ_CP049865.1\|WP_166235133.1\|1886590_1888228_+\|precorrin-2-C(20)-methyltransferase	gnl\|CDD\|381173	cd11646, Precorrin_3B_C17_MT, Precorrin-3B C(17)-methyltransferase (also named CobJ or CbiH). Precorrin-3B C(17)-methyltransferase participates in the pathway toward the biosynthesis of cobalamin (vitamin B12). There are two distinct cobalamin biosynthetic pathways. The aerobic pathway requires oxygen, and cobalt is inserted late in the pathway; the anaerobic pathway does not require oxygen, and cobalt insertion is the first committed step towards cobalamin synthesis. This model includes CobJ of the aerobic pathway and CbiH of the anaerobic pathway, both as stand-alone enzymes and when CobJ or CbiH form part of bifunctional enzymes, such as in Mycobacterium tuberculosis CobIJ where CobJ fuses with a precorrin-2 C(20)-methyltransferase domain, or Bacillus megaterium CbiH60, where CbiH is fused to a nitrite and sulfite reductase-like domain. In the aerobic pathway, once CobG has generated precorrin-3b, CobJ catalyzes the methylation of precorrin-3b at C-17 to form precorrin-4 (the extruded methylated C-20 fragment is left attached as an acyl group at C-1). In the corresponding anaerobic pathway, CbiH carries out this ring contraction, using cobalt-precorrin-3b as a substrate to generate a tetramethylated delta-lactone.	3.70874e-105
NZ_CP049865.1\|WP_166233460.1\|1880436_1882500_-\|phosphate-acetyltransferase	gnl\|CDD\|235537	PRK05632, PRK05632, phosphate acetyltransferase; Reviewed.	0
NZ_CP049865.1\|WP_166233455.1\|1873292_1875923_+\|hypothetical-protein	gnl\|CDD\|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	1.74597e-48
NZ_CP049865.1\|WP_166235129.1\|1868525_1868972_+\|hypothetical-protein	gnl\|CDD\|227933	COG5646, COG5646, Uncharacterized conserved protein [Function unknown].	4.07363e-06
NZ_CP049865.1\|WP_166233466.1\|1885832_1886498_+\|precorrin-8X-methylmutase	gnl\|CDD\|181352	PRK08285, cobH, precorrin-8X methylmutase; Reviewed.	1.43013e-110
NZ_CP049865.1\|WP_166233451.1\|1867673_1868099_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	3.08837e-27
NZ_CP049865.1\|WP_166233454.1\|1870650_1873296_+\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	1.5366e-84
NZ_CP049865.1\|WP_166233452.1\|1868109_1868520_+\|VOC-family-protein	gnl\|CDD\|319924	cd07263, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.57123e-36
NZ_CP049865.1\|WP_166233450.1\|1866125_1867214_+\|hypothetical-protein	gnl\|CDD\|282094	pfam04188, Mannosyl_trans2, Mannosyltransferase (PIG-V). This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.	0.000504967
NZ_CP049865.1\|WP_166233465.1\|1884921_1885836_+\|nitrite-reductase	gnl\|CDD\|274131	TIGR02435, Precorrin-3B_synthase, precorrin-3B synthase. An iron-sulfur protein. An oxygen atom from dioxygen is incorporated into the macrocycle at C-20. In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC 1.14.13.83, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; EC 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5 and precorrin-6A, respectively. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin].	1.07001e-32
NZ_CP049865.1\|WP_166233458.1\|1878002_1878779_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|223377	COG0300, DltE, Short-chain dehydrogenases of various substrate specificities [General function prediction only].	2.47904e-75
NZ_CP049865.1\|WP_166233459.1\|1879118_1880303_-\|acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NZ_CP049865.1\|WP_166233449.1\|1865025_1866138_+\|DUF2029-domain-containing-protein	gnl\|CDD\|227937	COG5650, COG5650, Predicted integral membrane protein [Function unknown].	1.70827e-21
NZ_CP049865.1\|WP_166233456.1\|1876077_1876209_+\|NAD(P)-binding-domain-containing-protein	gnl\|CDD\|224170	COG1250, FadB, 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism].	6.05086e-07
NZ_CP049865.1\|WP_166233461.1\|1882638_1883427_-\|deoxyribonuclease-IV	gnl\|CDD\|179214	PRK01060, PRK01060, endonuclease IV; Provisional.	3.83903e-86

>NZ_CP049865.1|WP_166233456.1|1876077_1876209_+|NAD(P)-binding-domain-containing-protein
MQITVLGAGTIGLSWVRRFVAGGHDVVVCDPRPDLADALATLP
>NZ_CP049865.1|WP_166233455.1|1873292_1875923_+|hypothetical-protein
MKPNRRAWATALVLLLVPLLVAGGLLWGTSRADAGLRGVQAAVVNNDEMVTVNGQAMPLGRQLAAELVDTDRDQNFTWVLASEEKAAEGLKSGRYAAVVTIPREFSAAASSFSKPANEAVRATIHVETSPVAGISETALGQSIADAAGNALNRFLTGEYLKNIYLGFNQMSEQMLEMVDGTRQLADGAGQLADGAGQSADGADQLAGGLQMAAAGSPQLRDGAAQSASGAQALADGLGLASAGGAQLRDGVSSATSGAHQLAGGARSLADGTRQWADGADTYANGVDTYADGVQTYADGVRTYADGVSQYTGTIVSLVQPIRDAISQLPEWAGWITKIKDVVADLTGNAIKLDAQIQQVIERIRDYVERTFGVADDASALAASAKAATTRAAKASAAPTAACPAEFAAVEGGCEAFAAGVAAAGKQAATADAQLEDALAGVRTKADALAAEADQAQQAGERILALLDKLSEASTKMVAWAPTVQAELQKLEAQIPPGTPTTKAEVLALLDQFLDASKQLDQGGQALATGGQQLAGGADQLAGGARELSSGARGLASGTDQIAGGVDGLAGGLDQLGAGVAAYTGGVDTAASGAAQLAGGLGQLSSGIDAYTGGVDQAAAGATQLADGLGQLSDGARGLADGTDELADGVAEGAGEIPTYSEADRDRLSSVVAAPVDTSGIEMLVRPNLAWVSLLLVSALWVGALATFAATGRTDRRAALSTAGTGQLLGRAFLPGLGIIAGQGVLLAILGAVALRLTAGEGALLTMVLLVAAGAFALLNFALARLLGNPGRLVSLGLLVVTMVTAATATAPSLFGALRGLSPVSPALDAVREVSTTGNVTIPVFILAGWAIIGAVGAVAAVARTRMVPLAALAARR
>NZ_CP049865.1|WP_166233454.1|1870650_1873296_+|MMPL-family-transporter
MLARPTPRGGGLARRRAGPRRPGGHRRRQLRRRVPDPGASSQKALDQLRMTFPQAAMSSSTMIVIAPDGRHITDADIKSVVEDADAKLDEIPWVDSTQTPYNEYVSGLISDDGTAGLIRVNILDASVSEFTDPQREILLEAGEELQAAIPGSTVHVGGEVFSVEMPHITPVEGIGVVVAIIVLIVVLGSFRAAIMPIISALVGAAASMLLIIAAAGIMPINSTTTMLALMLALAVGIDYSLFIVSRHRDQLATGMDAEESAARATATAGSAVVFAGMTVVIALVGLAVAQIPFLTTMGVFAAVAVAIEVALALTLLPAMLGFAGAKLAPKPSKKPGRKKFDASTWWVGVITRFPAVTIAAVVLILGALSIPAQNLQLALPNSGRNAPTATDRITFDAISDRFGVGYNGPLVITGSIVESTDPLGLLDDLKRDVEAVPGVKMVAMAVPNPNADTAMIQVIPTTGPDDPATSRLVHDLRALEPGWKAEHNVEMSVTGFTAIAIDVSDQLGAALLPFGIFVVGLSLVLLSIVFRSILVPIKAALGYLLSVGAAFGLTTLVFNQGIGKEIVNLHDPQPIISFLPIILMGILFGLAMDYEVFLTSRMREEYVHGNRTNPTEAGFVHSAKVVVAAAIIMIAVFAFFIPQGSGTIKPIAFGLAIGVGIDAFLVRMTLGPAVMRLLHGRAWWLPKWLARRMPVLDAEGEAITHQLALADWPYPGADHAVYGEGLEASDGDVELFSGIDLDVPRGGHVEVDGPPAARRALLLALTGRLALTGGDLKVLGLVLPQQAGQVRRQATFVDATDPDAAARLADPAGELVVIDDADRLDAAGRDALARLNERPDITVVAGVSAADDTAQGLTPRATNSHPAPAGVDDSVLVGGAA
>NZ_CP049865.1|WP_166233453.1|1869144_1869849_+|hypothetical-protein
MTTPAPSAPGRRIARIAGWLAMVVALNVGWVAGSIAPNQAAFRAFGVCARGACPEASDPGRWGAAWIVWGAGAALLALGAYVSLASTDVRDVGLRTGAVGGVQRALLGAAAVTGVLAVGMLAAGAGESVSFQWSAFLLTATAPLTALIFSLVVGRWSAPLRAAVGVVLGFFGPLLLTLVWESSITRTRTPGGELGGLYSWLLFRSPGAALGVAVALLAVVVFLASALPSRAARR
>NZ_CP049865.1|WP_166235129.1|1868525_1868972_+|hypothetical-protein
MAGKQGDGVGFSAEEKAAMKQRAEELKATKGVKGAAKTAKEYEACLAAIDALEGVDRQIGERLHVIVSEEAPDLAAKTFYGFPAYARDGKVVVFYQPASKFKTRYGTVSFDEEAALDDGVMWPVSFAVLEVTPAVEKDLRALVKRAAS
>NZ_CP049865.1|WP_166233452.1|1868109_1868520_+|VOC-family-protein
MTITIANSFLPHTDAEASTAFYRDVLGFEVRLDVGQGQMRWITVGPVGQDTAIVLHPPALDPGLTDAEKTTINELIAKGSLFSIHLATDDLDVAFAAIEAAGTEIVQEPMDQDWGSRDCAFRDPAGNMIRLQQKKG
>NZ_CP049865.1|WP_166233451.1|1867673_1868099_+|helix-turn-helix-transcriptional-regulator
MGQDLATLVLLRRVRDRIDREYAAPLDVEALARGVHLSAGHLSRQFKLAYGESPYQYLMTRRIERAMMLLRSADLSVTDVCFAVGFSSLGTFSTRFSELVGVPPSVYRERGAPFAPGMLPCIARQLTRPVRNREAGGAPAS
>NZ_CP049865.1|WP_166233450.1|1866125_1867214_+|hypothetical-protein
MARVKRLEDENLRIVQVWLLTRLLFAVIAVALAVMGQRPLDSVVAQWDVAHFLKISTEGYADPNEMAFFPGWPAVLHAVGLTGFSKVMGGTVIALACSLAAAFALKRIAGAWGAIAWLLAPTAVFTAVPYTEAPFCALAFWAWERATRDKWGQAAVLAALASTLRVSGLFLIGALFILALTQKLGRGQVLAVRLSWLVLPAAVIVVYVAYLYGLTGSWTAWFSAQEAGWQRGFHWPWEALANHWGVLWVPNAEHPEWPWVFRAELISWIVGVLVTLVALAKKRVAEASWVAVQVLAFSVSYWLMSVTRAVLLWFPLWRLIGEFIESRPRTRAWAVLGWIAAGIAVAVQCVWAWLYFTGRWSS
>NZ_CP049865.1|WP_166233449.1|1865025_1866138_+|DUF2029-domain-containing-protein
MGVSGIEDAQIPYVEADLEYPVLTGLFIYVTRLLSGVFPGDRMIAFFGTTAVALFLCFLGLILVHLRMPASEVGPVGGVRGWTGVRALDDREGADAWVRDPRWQAVMLAASPLVAAGALINWDLLPMLLASGAILAWARGRPGWSGALIGLGTAAKLYPALLLLPIALICLRDRRWRDGVATLAGAILGWLAVNLPVFLAAPDGWLHFWTFNTERTADLGSIWYVLEGLGVQFPSLTLLMAVGLILGAVGLAIAYLKAPAVPTLAQGALLIVLLFCLVNKVYSPQYMLWLLPLVVLARPVWVDWLVFTAGELVYWAAVWVYLDGGLLAGDGEPRAYWAAILVRMGTEIFVAARVVRDIVGARVEGRRWRE
>NZ_CP049865.1|WP_166233448.1|1864816_1865095_+|hypothetical-protein
MTASPLDTLLGGPRGSRAAASPRRAPLSPVLLALGLATVNWSILMARQAPCLADPGAQYSAGCYSDITALWGFRGSRTPRSPTSRRTWSIRS
>NZ_CP049865.1|WP_166233458.1|1878002_1878779_-|SDR-family-NAD(P)-dependent-oxidoreductase
MTTALVTGSTAGIGAEFARQLAARGDDLVLVARDQRRLAAQAQELAARYGVRCEVLPADLAVRADIDAVAARLASADAPVDVLVNNAGFGFTTTLLDADTAELERALDVMALAPMLLGGAAGRAMASRGRGTIITVASLAAWIAQGGYSAVKSFARVWSEGLAGELAGTGVTVTVLCPGWVTTEFHERAGLDGQARSIPGPVWVSAERCVREALADADRGKVVSIPTTRWKLAAFALQHLPRGVVHAISRRLSKAKQG
>NZ_CP049865.1|WP_166233459.1|1879118_1880303_-|acetate-kinase
MATPILLLNAGSSSIKYQMIDADTEEVLASGLIERIGQDVGVLTHKVNGEEFVANEEYSNHSLALAAMVQMFADHGPSLDDVRAVGHRTVHGGDKLTRTMLIDESVVATLEALSPLAPLHNPPGIAGIRGAQKALPNVPHVAVFDTAFFSTLPPASYTYAIPTDVAERYHIRRYGFHGTSHSYVSHRAAELLGKPYEQTSQIVCHLGNGASISAIKDGVAIDTSMGLTPLEGLVMGTRSGDVDPGMIAYLHREAGMSTDAIDTLLNKASGMLGLVGASDMRDVEAAKDDGDERAQLAWDVYIRRIVGYIGRYFVLLGGIDALSFTAGVGENSSSVRRDVVKGLAALGVTLDPVANTLRSKEARAISTKDSAFAVLVVPTNEELQMAREVKAVIA
>NZ_CP049865.1|WP_166233460.1|1880436_1882500_-|phosphate-acetyltransferase
MTRSIYVLAPEGLTGKSVVALGILDALTREVESVGVFRPLITGGDQPDQILSTLVHQPVVHEDYDEAFGVTYEDVRADADAALATILQRYNEVAAHYDTMVILGSDYTDNLGAQELQFNARVAANLNAPIALAVSAKNRTPDEVTQLARSTVDLLDKHHAQVIAVIPTRTPEGDQTPYADAVRAALPDVVVGTLPAHPVLAAPTLGAQVKAINGRQVAGRTDVMTHESQSVLVAAMTLPNVLARLEPESTVISPGDRTEIIPGIILAQRSGAFPPLTALVLTGGYEIPETMAQLIANIRQDLPIFVTDLGTYTTAEKLFGLEGTMTSSERKTELGRRLFSENVDADALLAAMRVDRAGIRTPLMFEYQLSEMARHDKRRIVLPESADDRILEAAATVLRRGTAEIILLGDATEVKNRALNLGLSLEGAEIVSMSDPDLVDRFSAEYARLRAKKGITLEQARDKMTDPSYFGTMMVHLGLADGMVSGAVNTTANTIRPSLEFIKTKPGVSVVSGSFLMCMADRVDVYADCAVNPDPTAEQLADIAISSAATARAFGIEPRVAMLSYSTGTSGQGADVDKVREATEIVKQRAPELKVEGPIQFDAAVDPTVGSKKMPGSEVAGQATVFIFPDLNTGNNTYKAVQRSAGALAVGPVLQGLNKPVNDLSRGALVDDIVNTIAITAIQAQHS
>NZ_CP049865.1|WP_166233461.1|1882638_1883427_-|deoxyribonuclease-IV
MSIEIGGHVDDPIAAAHADGFPIAQTFLGDPQAWKGHAVPHPGGAAGLKADAEAAGVGLFIHAPYVINVATTNNRIRIPSRQILAKQVKLATEVGARGVIVHGGHVNNGDDPQVGFDNWRKAIEGLDLTVPIFIENTAGGANAMARQLERIARLWDTIADAKGIENVGFCLDTCHAHAGGLDPDGLVDAIKGITGRIDLVHLNDSRDAAGSGADRHAVLGAGECEADYLVSVVREAGAPVILETPTADVSHADQIAWLRARL
>NZ_CP049865.1|WP_166233462.1|1883423_1883807_-|ACT-domain-containing-protein
MAGMTDLHEILGALRPYVRQGSYVYVTSENPPDVAFHARIVEDEGTTLVLDQAIADEHRLAYDGVFGWITLEAHTSLQAVGITAAVSTALARVGLSCNVIAGFYHDHLLVPIAHVDEAMDVLGGLSA
>NZ_CP049865.1|WP_166233463.1|1883884_1884385_-|hypothetical-protein
MPRAGRTPTALHSARNVASGTLEGVPFLTFEAEWAVDEAAVVWEQFRRRQVIVLDLPAAVAPLDVRGRVALDLRGMASDSPAFAKGWGVLASDERQAHAILTDEVRALVSELPPKEATWQFFGRDLVLGLTGYHGPDAVLRHTESARRLIRAVPAFVWSDASGVAG
>NZ_CP049865.1|WP_166233464.1|1884441_1884579_-|hypothetical-protein
MRTFRVFAGGPALVRLSGWLLNTPVRALRREGAPPRGGGSPPSTG
>NZ_CP049865.1|WP_166233465.1|1884921_1885836_+|nitrite-reductase
MSVLIRDRADRCPGILRPWPAADGLLVRVRLVGGRITARQLRGLSVAATVFGDGCVRPTTRANLQLRAFPGTDGVLDADALAAIEASGLLPAPAHDRVRNITVSPQTGLAGGRADLRPLAADLDAQIVASDVLPGLPGKFAFVLDDGRGDLIDRPCDVGLVALDAETVQLRVGEHYGAVVPLAAAARELIALAELFCAARGTGPTAPWHTYEMASPLVAPVDPDPRVPQATGPLPFGPVPGGLHAPVGDDGLDPADVDALLAGVDEVVFTPWKGVLIPSPTQVASSTHGGAAQADAGGSDAGQR
>NZ_CP049865.1|WP_166233466.1|1885832_1886498_+|precorrin-8X-methylmutase
MSGLRRPARRYPYVDAGADIYVDSFATIRREADLTGVPADAEKVAVRMIHGSGQVDLARDLVVHPGLLAAARGALEAGAPILCDATMVATGVTASRLPASNDVICLLNDPRVPDLARAFGTTRSAAAVSLWEPMLAGAVVAIGNAPTALFHLLELILDGGPRPAAIVGCPVGFIGAAESKQALVDLAADHGIDIPYVTVLGRRGGSAMTSSALNALAQEAE
>NZ_CP049865.1|WP_166235133.1|1886590_1888228_+|precorrin-2-C(20)-methyltransferase
MAIVGVGPGDPELITLKAARLIEDADVVAFHAAPGKASNARRIAAPLFPAGVVEEELTYPVTTGATDHPGGYAGAMGAFYEAAAARLADHLDAGRLVVLLAEGDPLFYGSGMYLHDRLATAYATAIVPGVPAFAAATAAAASPLVRQTDVLTVLPGTLPEPELARRLADTDGAIIMKLGRTFPAVRRALEASGRLDGAVYVERASMPEQRQLLVADVDAASVPYFSLIVVPGDARNGRRTRDAADPAIRAAVLRDGDGSDVPATRSAARPGGADGTSAPARSVAVGANVGGLHTAVPVPAELLVVGLGPGPDRWVTPEVTAALAEVEHVIGYGPYVNRVPQRAGLIRHASGNTVERDRARLALELAAAGERVAVVSGGDAGIFGMASAVFEVAEDPAFAGVPIRVLPGLSAVQAVAARAGAPIGGDFAVVSLSDRLKPWSVIEDRLVHIARADLVLALYNPASRSRTEQIARAHQVLLAHRAPETVVVVGRDVGRAEESLRVTTLGAFEPASIDMKCLVIVGASGTRVGPAGVWTPRFVPGEEAQ

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Crispr_ID: NZ_CP049865_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049865_4

3481947-3482104

Orphan

Consensus_repeat	Method
CGCGGAGAGAGCGACCTACGGGTCCAGAACGCCGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049865_4

>merge|NZ_CP049865|4|3481947-3482104|CRISPRCasFinder
CGCGGTGGGAGCGACCTACGGGTCCAAAACGCCGCGGAGAGAGCGACCTACGGGTCCAGAACGCCGCGGGGAGAGCGACCTCGGCGCCACCCCGACGTCCGCGTCCTGGCGGGCCAGAACGTCGCGGTGAGAGCGACCTACGGGTCCAGAACGCCGCG

>NZ_CP049865|4|4|3481947-3482104|CRISPRCasFinder
CGCGGTGGGAGCGACCTACGGGTCCAAAACGCCGCG	GAGAGAGCGACCTACGGGTCCAGAACGCCGCGGGGAGAGCGACCTCGGCGCCACCCCGACGTCCGCGTCCTGGCGGGCCAGAACGT
CGCGGTGAGAGCGACCTACGGGTCCAGAACGCCGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049865.1\|WP_166235418.1\|3477322_3478516_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP049865.1\|WP_166234645.1\|3472076_3472355_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049865.1\|WP_166234654.1\|3487816_3488995_-\|protein-translocase-subunit-SecF	unknown	unknown	gnl\|CDD\|237275
NZ_CP049865.1\|WP_166234659.1\|3494242_3495109_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293816
NZ_CP049865.1\|WP_166234644.1\|3470283_3471894_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP049865.1\|WP_166234646.1\|3474498_3475182_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293792
NZ_CP049865.1\|WP_166235416.1\|3473173_3474496_-\|histidine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234586
NZ_CP049865.1\|WP_166234652.1\|3486216_3487284_-\|potassium-channel-family-protein	unknown	unknown	gnl\|CDD\|367001
NZ_CP049865.1\|WP_166234657.1\|3492880_3493450_-\|crossover-junction-endodeoxyribonuclease-RuvC	unknown	unknown	gnl\|CDD\|234587
NZ_CP049865.1\|WP_166234649.1\|3478660_3479056_+\|TIGR03987-family-protein	unknown	unknown	gnl\|CDD\|274903
NZ_CP049865.1\|WP_166234656.1\|3492272_3492884_-\|Holliday-junction-branch-migration-protein-RuvA	unknown	unknown	gnl\|CDD\|234645
NZ_CP049865.1\|WP_166235414.1\|3472409_3473177_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187605
NZ_CP049865.1\|WP_166234653.1\|3487286_3487820_-\|adenine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|235028
NZ_CP049865.1\|WP_166234650.1\|3480366_3481719_+\|DUF222-domain-containing-protein	unknown	unknown	gnl\|CDD\|367155
NZ_CP049865.1\|WP_166234651.1\|3483882_3486171_-\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|223394
NZ_CP049865.1\|WP_166234647.1\|3475246_3476491_+\|DUF349-domain-containing-protein	unknown	unknown	gnl\|CDD\|377186
NZ_CP049865.1\|WP_166234648.1\|3476708_3477326_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP049865.1\|WP_166234655.1\|3491232_3492276_-\|Holliday-junction-branch-migration-DNA-helicase-RuvB	unknown	unknown	gnl\|CDD\|234619
NZ_CP049865.1\|WP_166234658.1\|3493486_3494254_-\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|234640
NZ_CP049865.1\|WP_166235420.1\|3483065_3483770_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|178549

Protein	Function_ID	Function_description	E-value
NZ_CP049865.1\|WP_166235418.1\|3477322_3478516_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	3.68272e-47
NZ_CP049865.1\|WP_166234659.1\|3494242_3495109_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293816	cd07730, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry. Some members of this subgroup are annotated as GumP protein.	4.81594e-39
NZ_CP049865.1\|WP_166234654.1\|3487816_3488995_-\|protein-translocase-subunit-SecF	gnl\|CDD\|237275	PRK13022, secF, protein translocase subunit SecF.	1.92056e-99
NZ_CP049865.1\|WP_166234644.1\|3470283_3471894_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	1.67108e-106
NZ_CP049865.1\|WP_166234646.1\|3474498_3475182_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293792	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site.	2.03107e-60
NZ_CP049865.1\|WP_166235416.1\|3473173_3474496_-\|histidine--tRNA-ligase	gnl\|CDD\|234586	PRK00037, hisS, histidyl-tRNA synthetase; Reviewed.	8.17011e-117
NZ_CP049865.1\|WP_166234652.1\|3486216_3487284_-\|potassium-channel-family-protein	gnl\|CDD\|367001	pfam02254, TrkA_N, TrkA-N domain. This domain is found in a wide variety of proteins. These protein include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.	3.19016e-24
NZ_CP049865.1\|WP_166234657.1\|3492880_3493450_-\|crossover-junction-endodeoxyribonuclease-RuvC	gnl\|CDD\|234587	PRK00039, ruvC, Holliday junction resolvase; Reviewed.	2.73772e-70
NZ_CP049865.1\|WP_166234649.1\|3478660_3479056_+\|TIGR03987-family-protein	gnl\|CDD\|274903	TIGR03987, TIGR03987_family_protein, TIGR03987 family protein. Conserved hypothetical protein.	1.95399e-41
NZ_CP049865.1\|WP_166234656.1\|3492272_3492884_-\|Holliday-junction-branch-migration-protein-RuvA	gnl\|CDD\|234645	PRK00116, ruvA, Holliday junction branch migration protein RuvA.	5.31396e-63
NZ_CP049865.1\|WP_166235414.1\|3472409_3473177_-\|SDR-family-oxidoreductase	gnl\|CDD\|187605	cd05347, Ga5DH-like_SDR_c, gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs. Ga5DH catalyzes the NADP-dependent conversion of carbon source D-gluconate and 5-keto-D-gluconate. This SDR subgroup has a classical Gly-rich NAD(P)-binding motif and a conserved active site tetrad pattern. However, it has been proposed that Arg104 (Streptococcus suis Ga5DH numbering), as well as an active site Ca2+, play a critical role in catalysis. In addition to Ga5DHs this subgroup contains Erwinia chrysanthemi KduD which is involved in pectin degradation, and is a putative 2,5-diketo-3-deoxygluconate dehydrogenase. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107,15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.2425e-67
NZ_CP049865.1\|WP_166234653.1\|3487286_3487820_-\|adenine-phosphoribosyltransferase	gnl\|CDD\|235028	PRK02304, PRK02304, adenine phosphoribosyltransferase; Provisional.	6.14988e-82
NZ_CP049865.1\|WP_166234650.1\|3480366_3481719_+\|DUF222-domain-containing-protein	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	1.55678e-20
NZ_CP049865.1\|WP_166234651.1\|3483882_3486171_-\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	gnl\|CDD\|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	0
NZ_CP049865.1\|WP_166234647.1\|3475246_3476491_+\|DUF349-domain-containing-protein	gnl\|CDD\|377186	pfam03993, DUF349, Domain of Unknown Function (DUF349). This domain is found singly or as up to five tandem repeats in a small set of bacterial proteins. There are two or three alpha-helices, and possibly a beta-strand.	4.66448e-13
NZ_CP049865.1\|WP_166234648.1\|3476708_3477326_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.76555e-73
NZ_CP049865.1\|WP_166234655.1\|3491232_3492276_-\|Holliday-junction-branch-migration-DNA-helicase-RuvB	gnl\|CDD\|234619	PRK00080, ruvB, Holliday junction branch migration DNA helicase RuvB.	0
NZ_CP049865.1\|WP_166234658.1\|3493486_3494254_-\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|234640	PRK00110, PRK00110, YebC/PmpR family DNA-binding transcriptional regulator.	2.51373e-123
NZ_CP049865.1\|WP_166235420.1\|3483065_3483770_+\|alpha/beta-hydrolase	gnl\|CDD\|178549	PLN02965, PLN02965, Probable pheophorbidase.	0.000487125

>NZ_CP049865.1|WP_166234650.1|3480366_3481719_+|DUF222-domain-containing-protein
METLIRTQSEAFLENVLTGLDDLDPNGLDRALLTDSERVGLAEQALAAAGRLQALAGVLVAEADRVAAPQAVVGVGTLSWLHDAQRMTRREAGRLLASAQELSSRPVLREATLTGAATPLQARAVTRVLAQLPEDLPDQKVRDAEAMMVGFCAQFDSHELSRLARHLLEVIAPEVAEESLARRLEREARHAHAVRHLSFTPDGMGSVLIKGSLPTVEAELLRAQVEAIAHLHHRRALDCADPLVEKATPTQRRADALVELARAAGVHQDAPNHGGDRPRIMVLIDHDRLVDDCRKAQLLDSGADLTPTQLRVLACDAGILPVVMNGAGEVLDVGRANRLVTPSIRAALVARDRGCVFPGCDRTAAACDAHHITPWQRGGPTSLPNLVLLCRHHHNTVEPDHRHPDTRWQIRLDHGIPVVIPPTRVDPQQRPRRNQRHHHRPPPAPDDSAS
>NZ_CP049865.1|WP_166234649.1|3478660_3479056_+|TIGR03987-family-protein
MLIPAIVLITAALLLYTAGVWGERRSGTLRPLHVALFAGGFLCDAGGTWLMSQIAGSGTYTTTGAASVLTTLMAVTGGLALILMGIHLAWAIGVLAKGSPAARATFHRFSVLVWAIWLVPYFTGMASAMIR
>NZ_CP049865.1|WP_166235418.1|3477322_3478516_-|sensor-histidine-kinase
MPPGAPSAAARALQFGEHALFALLLFIGVTQAAANGDLTGPLIGLVAAFTVWYVLGAVFAARMPKRWVAPLWFAVLAALWVAAAIHAPSLAWLAFALCLLALHLLPWVPGVITVFMVTGMAIIVLWPTASSPVSAVLGPVIGAFVTLGITVGYSMILKESAARGQLLEELSAAQADLVAVQEELATAQRDAGALAERARLARDIHDTLAQGYSSILLLSRAELATEPPNAALLAQIEQLAGENLVEARRVVHALSPAQLDEAPLPQAVRRLLDRLAAESGIRADLEVSGDPRLSSMSVDVAVLRLVQGALANVRQHADADRVVVSLAYEPTELLIDVVDDGVGFDPAVPPLAGDAGGFGLRALRERVAQLGGRLSVESRPGEGAAVAASIPLDGGGR
>NZ_CP049865.1|WP_166234648.1|3476708_3477326_-|response-regulator-transcription-factor
MTTVLVVDDHPVVRAGLVALLSTRPGIEVVGQAGTQAEALSAFGRERPDVVLMDLQLGADDGVSATRRLRERDPHARVLILTTYDTDADIVNAIEAGAVGYLLKDASPDALGAAVEAAARGETVFAPAVAGRLARRVIAPPDELTEREREVVALLAQGLTNRQIAKQLFLSEATVKTHLVHIFTKLNVDNRTAAVAAAREQGLLR
>NZ_CP049865.1|WP_166234647.1|3475246_3476491_+|DUF349-domain-containing-protein
MSDSAGPASFGRVEEDGTVYVTTADGERAVGQVPDVSTEEALAFFVRRFEALDLEITLLEQRLASGAVSPDDARHSIKTLRSSVSDANAVGDLASLTTRLEAMAPKLAEAAEARKAERAKQHEATREAKEAMVAEAEKLAGGNDWRGGVNRFRQLLEEWKALPRIDRATDDALWHRFSSARTTYTRRRKAQFAQQSAKWTEAKAIKEQIIEEARGLADSTEWGPTSGAFRDLMARWKAAGSAQRDADDKLWAEFRGIQDQFFNARSEAQNAQDAEFGGNLTAKQALLDKAEAEILPVSDPNEGRAAYRSFIEEYNALGKVPRDAMRGLDNRVRAIENAVKQAEAEEWKRTDPEARHRAEETVAMLSAEIEKLQTKIEKAEARSDAKAVKKAQDSIATYTVWLDQAKATLADFTR
>NZ_CP049865.1|WP_166234646.1|3474498_3475182_-|MBL-fold-metallo-hydrolase
MFLASFPAGPWQANCYLFGLTDGHVVVVDPGVDAAETVRRAVEEHDLTVDAVLLTHGHIDHVAEAAQVADHFGVPAWLHGADRELLTDPSSGREQMQQMIAQLGVEVREPADLRLIEGGETLHAAGADFDVVHAPGHRPGCVLFRVRPDEPLEGDLDELIFTGDVVFAGSIGRTDLPGGDDAVMRATLRDVVLPLPDAAALLPGHGPTTTMNHERTTNPYLQEAYLT
>NZ_CP049865.1|WP_166235416.1|3473173_3474496_-|histidine--tRNA-ligase
MRTKPLSGFPEFLPAGRIAELAVLDTLRETFELHGFAPIETRAVETMDALTRKGEITKEVYTVRRLHAVEGEAPKDDLGLHFDLTVPFARYVQEFAGHLAFPFRRYQIQKVWRGERPQEGRYREFTQADIDIVGDNTLAAHHDVEVALVMLEAFERLHTRFGLPPVVMHVNNRKLAEGFYRGLGVEDHLAVLQRVDKLDKIGPDAVAKLLVDDLGISPEAAAKCLELATIQTADTSFVEQVRALGVENPLLDEGLAALAEVVDAAAKAVPGRLVADLKIARGLDYYTGTVYETELTGFESLGSICSGGRYDSLATDGKRTWPGVGISIGVSRILAPLIGKGEFVASRSVPTCVLVAVDAEDTRVASNDVAARLRARGIPTEVAPKADKYGKQIRYADRRGIPFVWFGDTVKDIRTGDQSPADPDTWTPPAEDLTPSIARG
>NZ_CP049865.1|WP_166235414.1|3472409_3473177_-|SDR-family-oxidoreductase
MRRVGYLDDLFSLAGLRALVTGGSSGIGFALARALGGAGAAVTIVGRDPARLADAEARLAALGVPAVTVRADLGVAADLDRVAGDARESDILVNCAGVNPRPPLAETTEPELAEVLAVNLLAPFRLGQAAGPAMAERGFGRIINVGSQQSISAFGNSGVYGMGKAGLAGLTRSQAEAWSAHGVTANTLLPGFVATPMTAATLAIPGRAEALAARSMVGRNGVPQDFEPAVVFLASRAAGYVTGALLAVDGGFSVH
>NZ_CP049865.1|WP_166234645.1|3472076_3472355_-|hypothetical-protein
MTAQTPARRPLHLPQLAFYCYLLAPITAGFGGMLFLNASRYAGGGGHPGRVTWVEWQLLIGGGLVVLGIVLLGVGLVLSGVRHLAEQMLRGA
>NZ_CP049865.1|WP_166234644.1|3470283_3471894_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MSIQSAIVLDRLTFAFPGDEPVLDGLTASFAAGRTGLIGANGTGKTTLFRLIAGELTPTSGTLTVAGNAEVGYLPQNLTLRTDAQVADLLGIRPILDALDALEAGDADPAHFDAIGDRWDAGERALARLSAVVGTLGEPGDLRRRVARLSGGETILTALVGLELARTPVVLLDEPTNNLDAAARDRLYALVDGWRGTLLIASHDLDLLERLDATAELRYGALTVYGGPYSAYAEALAVEQEAARQAVRTAEQRVKAEHRSRMEAQTRQARSTRQGRAARDKGDVKVVLDFRQNRAEKSQADDRAMHAAREAAARAGLADAEARVRDDDRLTLTLPDPQVGSGRRLAELRGTDRSVVIAGPERVGLVGPNGVGKTTLLRALVAGEPSHLPADAVALTDRIGYLPQRLDGLRADRTPLQELTARAPHVPDRELRNALASFSLPGPLATRPIGALSGGERFRVALAALLLAEPANQLLVLDEPTNNLDLDTVEALVGALDAYRGGLLVVSHDRAFLRRLGLTRVLELDADGGLTDRDAA
>NZ_CP049865.1|WP_166235420.1|3483065_3483770_+|alpha/beta-hydrolase
MLLIAGHWLGAWAWDAVADALRTLGRRPLPLTLPGLDPHDPQRASRTLEDQASAIVLALLDADAAQRPAVVVAHSGANAPVSMVLDRRPDLVGHVVWVDSGPVAPGTVFLPDAPSDLAELPLPDFETLGGQASLDGLTPADLDRFRRCAVPEPGPVLTRPVPLTGDGRRDVPTTLVCCSIPSAQVVDAARGGHPMFAEVAALRQVGFVDLPTGHWPMWSRPTDLAAVIAGVGLA
>NZ_CP049865.1|WP_166234651.1|3483882_3486171_-|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase
MSETTSRQSGAEIEAPQPAPVVVPEQPRRSMRRMLAMLGSQKTSGNAALDPLFAAMRQHHQKVDTGLIERAYRTAEHFHDGQMRKSGDAYITHPLAVATILASLGLNEPTICAALLHDTVEDTGYTLAQLTNDFGDEIATMVDGVTKLDKMVYGESAKAETIRKMVIAMSRDIRVLIIKLADRLHNMRTISSLRPDKQIRIAKDTLEIYAPLAHRLGMNAIKWELEDLSFSVIEPKIYSEIVKLVAERAPLRDQYLSTVIEQVKQDLADNKIKATVYGRPKHYYSIYQKMMVRGRDFYDIYDLVGLRVLVDTKRECYDVLGVLHARWRPLPGRFKDYIAMPKFNLYQSLHTTVLGPGGKPVELQIRTNEMHKQAEYGVAAHWRYKEGKSAGDEINWVHSISEWQKETEDSGEFLDTFTEEIAKNEVFVFSPKGDVIALPAGSTPVDFAYAIHTEVGHRCIGARVNGRLVPLDSTLEMGMSIDILTSKAQNAGPSRDWLNFVKTPRARSKIRQHFSRERRDEAIEQGKEILAKQMRRSHLAARLLTPEVMAHLTQHFHVSDVPSLWAAIGEGSTSAQAVITQLVSVVGGDEAAAEASLVDEAVLVRGPHKLPRNHSGVVVDGDPDLYTKLAKCCLPVPGDPIMGFVTRSEGISVHRTDCTNVASLRQMPERIVPVSWAPTADAAFLVAVQVEGIDRAGMLNDLTKVLSEMHMSIVSVSANASKDHVFTMRLTFQTPDPRHLETVLRGLQRVPGVYEVSRVKPG
>NZ_CP049865.1|WP_166234652.1|3486216_3487284_-|potassium-channel-family-protein
MANGSSTSRWGYQALVRLPSVAESPVKELTRRALLALGIIAVNSLIVWLDRDSYSDNVAGDGLTLIDAIYYATVTVTTTGYGDITPVSQHARLLNALLVTPLRIAFLILLVGTTLEVLANEGRRAMSDARWRKKMRNHTVVLGYGTMGRSALTTLLRNGADSDKIVVVDSSQAAVDTANRNGLAAFLGDCTSRDLLRRAEVPKAKHIIVTVNRDDTAILTTLTARQLNPHAHLVVSVREADNVSLLRQSGADGVVTSSDAVGRLIGLSAVSPELGATMEDLLNYGEGIDIAQRLVTPSEVGKSSSEIAGERVLGVVRGGLLRHFFDPSVALLKTGDELVIVRPSEKKRDRTPPTA
>NZ_CP049865.1|WP_166234653.1|3487286_3487820_-|adenine-phosphoribosyltransferase
MNPNQRRIVELIRDVPDWPKAGVVFKDITPLLADPAGFAAAIEELVALAPGPIDIVVGMEARGFIFAAPVALKLGAGFVPVRKPGKLPGQVDEQSFALEYGHETLAIHSDALWQGARVMVIDDVLATGGTIGATAELIKRQGAELVHVAVLMELGFLGGRERLAKAGVDTLSAVVTV
>NZ_CP049865.1|WP_166234654.1|3487816_3488995_-|protein-translocase-subunit-SecF
MSKRNGLAHRLYTGEISYDFIGNAKRFYIVSAVILAICLASLGFRQLNLSIDFTGGSEFVVPTQVTQTTVDDYREVVQDSTVPDLGEIKVNTVGDNQVRVQVRALTAEEINDVTALLAAKAGVPTEQVTNNLIGASWGQQITQQGLIALVVFMALVSLMIWAYFRNWKMSAAAILALVHDLIVTAGIYSILQFAFTPATLIGMLTILGYSLYDTVVVFDKIRDNTRDITQQNRTFAAAANLAVNQVLVRSINTTIIGVLPVAALLFTGVFVLGTGPLKDLGLALFVGMIAGAYSSLFLAAPLYVQMREREPELAAHRRRIERGAKRTKRAADEPAETVEEAAATVSGVSSEPVLSASGTPVDPVRLGTVRGVDLPRSQPQRSTRAARKKDAR
>NZ_CP049865.1|WP_166234655.1|3491232_3492276_-|Holliday-junction-branch-migration-DNA-helicase-RuvB
MTPRIADDPLDPHGRTDEIAVDGALRPPSLDEFKGQPRVAEQLGLVLAAAQHRNAVPDHVLLSGPPGLGKTTLAMIIAHELGAPLRISSGPAIQHAGDLAAILSGLTEGEVFFLDEIHRMSRPAEEMLYMAMEDFRVDVIVGKGPGATEIPLEIPPFVLVGATTRAGLLPGPLRDRFGFTGQLDYYDAADLVGIVQRSASLLDIAVDRASASVIAGRSRGTPRIANRLLRRVRDFALVKASGRIDPDVAAAALELYEVDALGLDRLDRSVLEALCVRFAGGPVGLGTLAMSVGEEAETVEEVAEPFLIRQGFLMRTPRGRVATQRAWQHLGLKVPASRADLFSDADG
>NZ_CP049865.1|WP_166234656.1|3492272_3492884_-|Holliday-junction-branch-migration-protein-RuvA
MIAHVNGTVSQVGGTWVVLDLGGFGVRALATPATVAAVTVGESASLHTSLVVREDSLTLYGFTDADERDAFELVQTASGIGPKLAQAIVSVLPPDELRTAIMTENLVALCKVPGIGRKGAQKMVIELKDKVNALGAIPALSTTGAARPAADEWREQVASGLESLGWSAKDAAAAVEGVAPLREQDPALGIGELMRAALRSLAR
>NZ_CP049865.1|WP_166234657.1|3492880_3493450_-|crossover-junction-endodeoxyribonuclease-RuvC
MRVLGIDPGLTRCGVGVIEGDPGRPPRLLLADVVRTASDADIGQRLADLERSLVQYVAEYRPDAIAVERVFARRDVSTIIGTAQASGVVLLVGTRAGLQVAQHTPSEVKAAITGNGRADKAQVGQMVMRILKLDAPPKPADAADAVALAVCHLWRAPAIARIRQAQVRRELVQAQAAARARAANRRKLA
>NZ_CP049865.1|WP_166234658.1|3493486_3494254_-|YebC/PmpR-family-DNA-binding-transcriptional-regulator
MSGHSKWATTKHKKAVIDAKRGKLFANLIKKIEVSARVGGGDPGGNPTLYDAIVKAKKNSVPNDNIDRAVKRGSGVGGEAVDYTEIMYEAYGAAGVAILIEVLTDNRNRSASDVKVAITRNGGTVADVGSVSRIYDRKGVVVVTKKQDGKDVSEDDLLEATLDAEPEDITDLGETFEIVCDPAQLVEVRKAVQAAGLDYDSADVEFRAQYEQAVDSADAAEKLFKLLDAIEDVDDVQNVYSNEDVPDEILESLEG
>NZ_CP049865.1|WP_166234659.1|3494242_3495109_+|MBL-fold-metallo-hydrolase
MTAHGSPSLVSVSGPAFSLPEPTPPLGCGRGWRCAPWRSDPSGSRPPSSSRGCSGPGAARSATRRSCSTTPRAPARRPRDQRGVGRSAGPGRAAEPIHNALRPPPGTLTTLEGLERAGVAPDMLDAALVTHLHSDHVQGLEDLPGTELWVHGPDLAWARAERPRGVGAALLDRPIRELSLPGGPVFTFERSLDLLGDGSVVLVDLAGHTPGSVGVLAHTASGWVLLAGDAAWNHAQVDAVRQKPAVPGEVVDTDRDASFATLHRLHAARSRVAVVPAHDHALTAGRAW

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP049865_2	2.1\|672613\|29\|NZ_CP049865\|CRISPRCasFinder	672613-672641	29	NZ_CP049865.1	672761-672789	2	0.931

1. spacer 2.1|672613|29|NZ_CP049865|CRISPRCasFinder matches to position: 672761-672789, mismatch: 2, identity: 0.931

cgcaccgacccagccgccactccacggga	CRISPR spacer
cgcacccacccagccgccagtccacggga	Protospacer
****** ************ *********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP049865_2	2.1\|672613\|29\|NZ_CP049865\|CRISPRCasFinder	672613-672641	29	NC_014214	Meiothermus silvanus DSM 9946 plasmid pMESIL02, complete sequence	12547-12575	7	0.759

1. spacer 2.1|672613|29|NZ_CP049865|CRISPRCasFinder matches to NC_014214 (Meiothermus silvanus DSM 9946 plasmid pMESIL02, complete sequence) position: , mismatch: 7, identity: 0.759

cgcaccgacccagccgccactccacggga	CRISPR spacer
ccaaccgacccagccgccgctccaccttg	Protospacer
*  ***************.******   .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1669821 : 1709527

Mycobacterium_phage(44.44%)

integrase,transposase

attL 1701135:1701156|attR 1709784:1709805

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_166233323.1\|1669821_1671045_+\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	1.0e-174	76.1
WP_166233324.1\|1671625_1672840_-	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
WP_166233325.1\|1672854_1673385_-	hypothetical protein	NA	NA	NA	NA
WP_166233326.1\|1679838_1680084_+	hypothetical protein	NA	NA	NA	NA
WP_166235104.1\|1680061_1681285_-	hypothetical protein	NA	NA	NA	NA
WP_166233327.1\|1681486_1681795_+	hypothetical protein	NA	NA	NA	NA
WP_166233328.1\|1681791_1682244_+	hypothetical protein	NA	NA	NA	NA
WP_166233329.1\|1682240_1682990_+	hypothetical protein	NA	NA	NA	NA
WP_166233330.1\|1683114_1688283_+	DEAD/DEAH box helicase	A0A1B1IUF6	uncultured_Mediterranean_phage	2.8e-27	32.3
WP_166233331.1\|1688279_1691090_+	DEAD/DEAH box helicase	A0A1B1IUI1	uncultured_Mediterranean_phage	6.5e-31	26.2
WP_166233332.1\|1694985_1695846_+	hypothetical protein	NA	NA	NA	NA
WP_166235106.1\|1696051_1697983_+	AAA domain-containing protein	K4I1H4	Acidithiobacillus_phage	8.8e-27	30.6
WP_166233333.1\|1697957_1698881_+	hypothetical protein	NA	NA	NA	NA
WP_166233334.1\|1698823_1699153_+	hypothetical protein	NA	NA	NA	NA
WP_166233335.1\|1699450_1699690_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_166233336.1\|1699723_1700833_-\|integrase	site-specific integrase	A0A2D1G850	Mycobacterium_phage	1.6e-44	36.0
1701135:1701156	attL	NA	NA	NA	NA
WP_166233337.1\|1703340_1704589_+\|transposase	IS3 family transposase	U5P429	Shigella_phage	3.3e-27	35.1
WP_166233338.1\|1705467_1706844_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	1.4e-34	38.5
WP_166233339.1\|1706940_1707990_-\|integrase	site-specific integrase	A0A1D8EZV4	Mycobacterium_phage	5.8e-41	33.9
WP_166233340.1\|1708219_1709527_-\|transposase	ISL3 family transposase	A0A2H4PDF8	Mycobacterium_phage	2.7e-197	77.2
1709784:1709805	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP049865

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection