CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NZ_CP046030	Staphylococcus chromogenes strain 1401 plasmid unnamed2, complete sequence	0 crisprs	NA	0	1
NZ_CP046031	Staphylococcus chromogenes strain 1401 plasmid unnamed3, complete sequence	0 crisprs	NA	0	0
NZ_CP046029	Staphylococcus chromogenes strain 1401 plasmid unnamed1	0 crisprs	Cas14u_CAS-V,casR	0	0
NZ_CP046028	Staphylococcus chromogenes strain 1401 chromosome, complete genome	3 crisprs	cas1,cas2,csa3,WYL,DEDDh,cas3,DinG	7	5

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 43171

Staphylococcus_phage(62.75%)

head,portal,integrase,terminase,tail,capsid

attL 8997:9013|attR 37865:37881

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_165886017.1\|445_1690_+\|capsid	phage major capsid protein	Q8SDK8	Staphylococcus_phage	1.6e-178	79.7
WP_165886018.1\|1702_1861_+	hypothetical protein	A0A1J0MFP2	Staphylococcus_phage	1.6e-11	67.3
WP_165886019.1\|1870_2161_+\|head,tail	phage head-tail adapter protein	A0A1J0MFU4	Staphylococcus_phage	1.3e-35	74.2
WP_165886055.1\|2141_2474_+\|head,tail	head-tail adaptor protein	A0A1J0MG09	Staphylococcus_phage	1.1e-43	74.3
WP_165886020.1\|2473_2851_+	hypothetical protein	A0A1J0MGE3	Staphylococcus_phage	7.1e-42	68.0
WP_165886021.1\|2847_3210_+	DUF806 family protein	A0A1J0MFP0	Staphylococcus_phage	1.9e-44	67.2
WP_165886022.1\|3221_4160_+	hypothetical protein	A0A1J0MFV0	Staphylococcus_phage	7.8e-138	81.0
WP_165886023.1\|4228_4675_+	hypothetical protein	A0A1J0MFL9	Staphylococcus_phage	2.4e-60	82.4
WP_165886024.1\|4716_4860_+	hypothetical protein	A0A1J0MFX7	Staphylococcus_phage	3.1e-14	80.4
WP_165886025.1\|4884_9462_+\|tail	phage tail tape measure protein	A0A1J0MFP9	Staphylococcus_phage	0.0e+00	71.7
8997:9013	attL	NA	NA	NA	NA
WP_165886026.1\|9461_10952_+\|tail	phage tail protein	A0A1J0MFV2	Staphylococcus_phage	6.2e-206	68.3
WP_165886027.1\|10953_14913_+	hypothetical protein	A0A2H4J300	uncultured_Caudovirales_phage	0.0e+00	48.7
WP_165886028.1\|14896_15037_+	hypothetical protein	NA	NA	NA	NA
WP_165886029.1\|15083_15359_+	hypothetical protein	A0A1J0MFP4	Staphylococcus_phage	1.3e-37	84.6
WP_165886030.1\|15400_15745_+	hypothetical protein	NA	NA	NA	NA
WP_060551316.1\|15884_16133_+	hypothetical protein	Q4ZD59	Staphylococcus_phage	2.0e-37	92.7
WP_165885630.1\|16134_17604_+	peptidoglycan DD-metalloendopeptidase family protein	A0A1J0MFY3	Staphylococcus_phage	9.4e-231	81.0
WP_060550760.1\|18012_18507_-	Asp23/Gls24 family envelope stress response protein	NA	NA	NA	NA
WP_060550761.1\|18548_18791_-	DUF2273 domain-containing protein	NA	NA	NA	NA
WP_156407420.1\|18811_19363_-	alkaline shock response membrane anchor protein AmaP	NA	NA	NA	NA
WP_060550705.1\|20028_21078_-\|integrase	site-specific integrase	W5R968	Staphylococcus_phage	5.4e-156	75.0
WP_165886031.1\|21390_22014_+	hypothetical protein	B7T0F3	Staphylococcus_virus	4.2e-79	75.4
WP_165886032.1\|23365_23995_-	helix-turn-helix domain-containing protein	A0A0N9SKN0	Staphylococcus_phage	2.8e-99	86.5
WP_165886033.1\|24147_24375_+	helix-turn-helix transcriptional regulator	A0A0N7GFI4	Staphylococcus_phage	1.1e-32	91.8
WP_165886034.1\|24413_25181_+	phage antirepressor	Q4ZAL8	Staphylococcus_virus	3.9e-111	80.2
WP_019166719.1\|25217_25436_+	hypothetical protein	NA	NA	NA	NA
WP_165886035.1\|25432_25807_-	hypothetical protein	NA	NA	NA	NA
WP_165886036.1\|25867_26758_+	DUF3102 domain-containing protein	A0A2H4JAH5	uncultured_Caudovirales_phage	2.1e-47	75.2
WP_165886037.1\|26760_27348_+	hypothetical protein	NA	NA	NA	NA
WP_165886038.1\|27359_27581_+	hypothetical protein	A0A0F6N4M2	Staphylococcus_phage	1.6e-30	91.8
WP_165886039.1\|27714_27927_-	hypothetical protein	A0A2H4JBA9	uncultured_Caudovirales_phage	1.3e-16	58.0
WP_060550713.1\|27999_28212_+	hypothetical protein	A0A1W6JNP3	Staphylococcus_phage	1.0e-21	69.6
WP_165886040.1\|28205_28379_+	hypothetical protein	Q4ZC27	Staphylococcus_virus	1.5e-07	66.0
WP_165886041.1\|28460_28727_+	DUF1108 family protein	Q4ZDY8	Staphylococcus_virus	1.3e-10	38.1
WP_107389409.1\|28723_28942_+	DUF2483 family protein	Q4ZC24	Staphylococcus_virus	1.8e-29	81.9
WP_165886042.1\|28938_29583_+	ERF family protein	D2JGK1	Staphylococcus_phage	2.4e-106	93.3
WP_165886043.1\|29575_29995_+	single-stranded DNA-binding protein	A0A1J0MFD7	Staphylococcus_phage	6.7e-49	86.1
WP_165886044.1\|30008_30683_+	hypothetical protein	A0A1J0MFX6	Staphylococcus_phage	2.1e-113	86.5
WP_165886045.1\|30921_31716_+	DnaD domain protein	A0A223LFI6	Staphylococcus_phage	6.2e-88	83.8
WP_165886056.1\|31766_32054_+	hypothetical protein	Q4ZC18	Staphylococcus_virus	1.4e-37	80.0
WP_165885614.1\|32046_33285_+	AAA family ATPase	Q4ZC17	Staphylococcus_virus	8.2e-228	97.8
WP_165885615.1\|33486_33909_+	RusA family crossover junction endodeoxyribonuclease	Q4ZC15	Staphylococcus_virus	5.7e-72	92.9
WP_165885616.1\|33910_34330_+	hypothetical protein	Q4ZC14	Staphylococcus_virus	5.9e-21	41.6
WP_165886046.1\|34326_34515_+	hypothetical protein	Q4ZC13	Staphylococcus_virus	5.9e-21	76.2
WP_165886047.1\|34514_34727_+	hypothetical protein	Q4ZC11	Staphylococcus_virus	2.5e-20	65.7
WP_165886048.1\|34739_35138_+	hypothetical protein	A0A1J0MFF1	Staphylococcus_phage	4.0e-11	40.6
WP_060552463.1\|35233_35467_+	hypothetical protein	Q4ZC08	Staphylococcus_virus	1.3e-25	86.2
WP_060550730.1\|35450_35747_+	hypothetical protein	Q4Z930	Staphylococcus_phage	3.9e-35	83.5
WP_165886049.1\|35739_35925_+	hypothetical protein	NA	NA	NA	NA
WP_060550732.1\|35917_36148_+	hypothetical protein	NA	NA	NA	NA
WP_060550733.1\|36131_36491_+	nuclease	Q4ZC06	Staphylococcus_virus	4.0e-58	90.8
WP_060550734.1\|36491_37010_+	dUTP pyrophosphatase	Q4ZC04	Staphylococcus_virus	4.5e-63	77.2
WP_060551333.1\|37328_37844_+	hypothetical protein	A0A1D6Z237	Staphylococcus_phage	3.7e-09	42.6
WP_165885622.1\|37905_38124_+	hypothetical protein	A0A2H4J460	uncultured_Caudovirales_phage	2.5e-23	72.2
37865:37881	attR	NA	NA	NA	NA
WP_165886050.1\|38141_38537_+	hypothetical protein	A0A2H4J610	uncultured_Caudovirales_phage	2.2e-57	82.4
WP_165886051.1\|38697_39060_+	hypothetical protein	A0A1J0MFN7	Staphylococcus_phage	4.9e-40	68.8
WP_165886052.1\|39064_39442_+	HNH endonuclease	A0A1J0MFT4	Staphylococcus_phage	9.0e-53	77.7
WP_019165882.1\|39534_40008_+\|terminase	phage terminase small subunit P27 family	A0A1J0MG04	Staphylococcus_phage	4.9e-64	80.9
WP_165886053.1\|40007_41711_+\|terminase	terminase	A0A1J0MGD9	Staphylococcus_phage	9.0e-294	87.1
WP_165886054.1\|41724_41922_+	hypothetical protein	A0A1J0MFN2	Staphylococcus_phage	2.2e-10	63.1
WP_165886057.1\|41974_43171_+\|portal	phage portal protein	D2JLE6	Staphylococcus_phage	5.2e-195	86.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP046028

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP046028_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046028_1

87847-88128

Orphan

Consensus_repeat	Method
TCGGCTCAGGTGTNGGTT	CRT

6 spacers

The CRISPR arrays of NZ_CP046028_1

>merge|NZ_CP046028|1|87847-88128|CRT
TCGGCTCAGGTGTCGGTTCAGGACTTGGTTCTGGAGTTGGGTTAGGATTCGGCTCAGGTGTCGGTTCCGGACTTGGTTCCGGAGTCGGGTTAGGGTTCGGCTCAGGTGTCGGTTCCGGAGTCGGGTTAGGGTTCGGCTCAGGTGTCGGTTCAGGACTTGGCTCCGGAGTCGGGTTAGGGTTCGGCTCAGGCGTTGGTTCAGGACTTGGCTCCGGAGTCGGGTTAGGGTTTGGTTCTGGTGTCGGATTTGGATCTGGATCCGGAGTCGGTTGCGGTGTTGGTT

>NZ_CP046028|1|1|87847-88128|CRT
TCGGCTCAGGTGTCGGTT	CAGGACTTGGTTCTGGAGTTGGGTTAGGAT
TCGGCTCAGGTGTCGGTT	CCGGACTTGGTTCCGGAGTCGGGTTAGGGT
TCGGCTCAGGTGTCGGTT	CCGGAGTCGGGTTAGGGT
TCGGCTCAGGTGTCGGTT	CAGGACTTGGCTCCGGAGTCGGGTTAGGGT
TCGGCTCAGGCGTTGGTT	CAGGACTTGGCTCCGGAG
TCGGGTTAGGGTTTGGTT	CTGGTGTCGGATTTGGATCTGGATCCGGAG
TCGGTTGCGGTGTTGGTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046028.1\|WP_165885333.1\|91141_92890_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236892
NZ_CP046028.1\|WP_151364418.1\|85008_86547_-\|YSIRK-type-signal-peptide-containing-protein	unknown	unknown	gnl\|CDD\|273479
NZ_CP046028.1\|WP_107363795.1\|83915_84875_+\|amidohydrolase	unknown	unknown	gnl\|CDD\|368185
NZ_CP046028.1\|WP_145399881.1\|79867_81730_+\|anaerobic-ribonucleoside-triphosphate-reductase	unknown	unknown	gnl\|CDD\|236436
NZ_CP046028.1\|WP_103159643.1\|105084_105582_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046028.1\|WP_103159031.1\|82492_83836_+\|multidrug-efflux-MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP046028.1\|WP_103159608.1\|98078_98663_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|274100
NZ_CP046028.1\|WP_105986918.1\|75755_76151_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|225446
NZ_CP046028.1\|WP_145399897.1\|98827_100603_+\|oleate-hydratase	unknown	unknown	gnl\|CDD\|237575
NZ_CP046028.1\|WP_165885334.1\|92942_94973_-\|amidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|236304
NZ_CP046028.1\|WP_107363800.1\|76180_77332_+\|N-acetylglucosamine-6-phosphate-deacetylase	unknown	unknown	gnl\|CDD\|238434
NZ_CP046028.1\|WP_151364416.1\|81716_82250_+\|anaerobic-ribonucleoside-triphosphate-reductase-activating-protein	unknown	unknown	gnl\|CDD\|379137
NZ_CP046028.1\|WP_145399877.1\|77629_78523_+\|5'-nucleotidase,-lipoprotein-e(P4)-family	unknown	unknown	gnl\|CDD\|273674
NZ_CP046028.1\|WP_165885338.1\|105683_107123_-\|6-phospho-beta-glucosidase	unknown	unknown	gnl\|CDD\|181973
NZ_CP046028.1\|WP_165885335.1\|95183_98012_+\|YhgE/Pip-domain-containing-protein	unknown	unknown	gnl\|CDD\|224428
NZ_CP046028.1\|WP_165885337.1\|103975_104863_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|283645
NZ_CP046028.1\|WP_165885331.1\|86566_87268_-\|superantigen-like-protein	unknown	unknown	gnl\|CDD\|171852
NZ_CP046028.1\|WP_145399879.1\|78688_79612_+\|lactate-dehydrogenase	unknown	unknown	gnl\|CDD\|133426
NZ_CP046028.1\|WP_165885336.1\|100708_102340_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|334852
NZ_CP046028.1\|WP_103159605.1\|103095_103926_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806

Protein	Function_ID	Function_description	E-value
NZ_CP046028.1\|WP_165885333.1\|91141_92890_+\|hypothetical-protein	gnl\|CDD\|236892	PRK11281, PRK11281, mechanosensitive channel MscK.	0.0013476
NZ_CP046028.1\|WP_151364418.1\|85008_86547_-\|YSIRK-type-signal-peptide-containing-protein	gnl\|CDD\|273479	TIGR01168, M_protein_serotype, Gram-positive signal peptide, YSIRK family. Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology. There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus.	0.00948128
NZ_CP046028.1\|WP_107363795.1\|83915_84875_+\|amidohydrolase	gnl\|CDD\|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	2.91216e-25
NZ_CP046028.1\|WP_145399881.1\|79867_81730_+\|anaerobic-ribonucleoside-triphosphate-reductase	gnl\|CDD\|236436	PRK09263, PRK09263, anaerobic ribonucleoside triphosphate reductase; Provisional.	0
NZ_CP046028.1\|WP_103159031.1\|82492_83836_+\|multidrug-efflux-MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.15741e-92
NZ_CP046028.1\|WP_103159608.1\|98078_98663_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|274100	TIGR02366, conserved_hypothetical_protein, probable dihydroxyacetone kinase regulator. The seed alignment for this family was built from a set of closely related uncharacterized proteins associated with operons for the type of bacterial dihydroxyacetone kinase that transfers PEP-derived phosphate from a phosphoprotein, as in phosphotransferase system transport, rather than from ATP. Members have a TetR transcriptional regulator domain (pfam00440) at the N-terminus and sequence homology throughout.	1.16001e-08
NZ_CP046028.1\|WP_105986918.1\|75755_76151_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|225446	COG2893, ManX, Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism].	1.6368e-30
NZ_CP046028.1\|WP_145399897.1\|98827_100603_+\|oleate-hydratase	gnl\|CDD\|237575	PRK13977, PRK13977, myosin-cross-reactive antigen; Provisional.	0
NZ_CP046028.1\|WP_165885334.1\|92942_94973_-\|amidase-domain-containing-protein	gnl\|CDD\|236304	PRK08581, PRK08581, amidase domain-containing protein.	0
NZ_CP046028.1\|WP_107363800.1\|76180_77332_+\|N-acetylglucosamine-6-phosphate-deacetylase	gnl\|CDD\|238434	cd00854, NagA, N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to amino-sugar-nucleotides, which is needed for cell wall peptidoglycan and teichoic acid biosynthesis. Deacetylation of N-acetylglucosamine is also important in lipopolysaccharide synthesis and cell wall recycling.	1.52838e-163
NZ_CP046028.1\|WP_151364416.1\|81716_82250_+\|anaerobic-ribonucleoside-triphosphate-reductase-activating-protein	gnl\|CDD\|379137	pfam13353, Fer4_12, 4Fe-4S single cluster domain. This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.	2.8855e-58
NZ_CP046028.1\|WP_145399877.1\|77629_78523_+\|5'-nucleotidase,-lipoprotein-e(P4)-family	gnl\|CDD\|273674	TIGR01533, Lipoprotein_E, 5'-nucleotidase, lipoprotein e(P4) family. This model represents a set of bacterial lipoproteins belonging to a larger acid phosphatase family (pfam03767), which in turn belongs to the haloacid dehalogenase (HAD) superfamily of aspartate-dependent hydrolases. Members are found on the outer membrane of Gram-negative bacteria and the cytoplasmic membrane of Gram-positive bacteria. Most members have classic lipoprotein signal sequences. A critical role of this 5'-nucleotidase in Haemophilus influenzae is the degradation of external riboside in order to allow transport into the cell. An earlier suggested role in hemin transport is no longer current. This enzyme may also have other physiologically significant roles. [Transport and binding proteins, Other, Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides].	1.13577e-94
NZ_CP046028.1\|WP_165885338.1\|105683_107123_-\|6-phospho-beta-glucosidase	gnl\|CDD\|181973	PRK09589, celA, 6-phospho-beta-glucosidase; Reviewed.	0
NZ_CP046028.1\|WP_165885335.1\|95183_98012_+\|YhgE/Pip-domain-containing-protein	gnl\|CDD\|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	1.15462e-129
NZ_CP046028.1\|WP_165885337.1\|103975_104863_+\|alpha/beta-hydrolase	gnl\|CDD\|283645	pfam06028, DUF915, Alpha/beta hydrolase of unknown function (DUF915). This family consists of several bacterial proteins of unknown function. Members of this family have an alpha/beta hydrolase fold.	1.65321e-100
NZ_CP046028.1\|WP_165885331.1\|86566_87268_-\|superantigen-like-protein	gnl\|CDD\|171852	PRK13036, PRK13036, superantigen-like protein; Reviewed.	1.49246e-66
NZ_CP046028.1\|WP_145399879.1\|78688_79612_+\|lactate-dehydrogenase	gnl\|CDD\|133426	cd05290, LDH_3, A subgroup of L-lactate dehydrogenases. L-lactate dehydrogenases (LDH) are tetrameric enzymes catalyzing the last step of glycolysis in which pyruvate is converted to L-lactate. This subgroup is composed of some bacterial LDHs from firmicutes, gammaproteobacteria, and actinobacteria. Vertebrate LDHs are non-allosteric, but some bacterial LDHs are activated by an allosteric effector such as fructose-1,6-bisphosphate. LDHs are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenase, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	6.56785e-115
NZ_CP046028.1\|WP_165885336.1\|100708_102340_-\|hypothetical-protein	gnl\|CDD\|334852	pfam02216, B, B domain. This family contains the B domain of Staphylococcal protein A, which specifically binds to the Fc portion of immunoglobulin G.	1.35534e-07
NZ_CP046028.1\|WP_103159605.1\|103095_103926_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	3.73895e-10

>NZ_CP046028.1|WP_165885331.1|86566_87268_-|superantigen-like-protein
MKLSTIAKTSLALGILTTGVMTTHAQSVDANGFNKGLQLITDENKELVEYYKKPSFDFKNVNGFKDGDKFEFVDSKTNQFVKVDLLGKDKHNLKEGASTNQDVFVVKENNSRQAETLSIGGITKSNGHDSIDPTVYPTLSLIEKNGNVISNKNIGQYPINKKEISLKELDFKLRQKLMDEHGLYKDKANKGDIVVKMKDGGKYTFELDKKLQDHRMGDVIDATQIDRIDVEYK
>NZ_CP046028.1|WP_151364418.1|85008_86547_-|YSIRK-type-signal-peptide-containing-protein
MRENFKLRKMKVGLVSVAIAAMYITIQGQAEASENVAEVNQPTAKQSIVEKQVETNPQLNTETQVNPTVHSPEQVDSKQKETKADTQENFVRLNQVQPGDTKITGKTVPNQIVSLTLDGKSVGSVEGENIGFVMASESGDFEFDLKDRKIVYNQKVDVSSSNLNFELEDEGSEDEMMEEEIAEATDTTTTGRYDKAYEIPTQQLEKKNGHHQVLVEPIIQDSGIIKGHTSVKGRVALAINNKFVDLGFDDFDKNTPLEKAKSRNEGIWKFIDAKGYFEFDFKRKPFENYHLKKDDLVSLTFKPDDEEEALNPLIFNVKVSDFDTVASATTTYRPDDVKKVVTLNNDADDLEVENIHGFVYESDRGIDKPVEGGQGTRIIKGKTKFANAVVNVTSSLGEGNEFPDLQVNDRGEFSFNASEAGYRLNNGEKLHFTVVNPLNGNILSKLVTKEVQVAESEEQKKERVFDELLEVTPAYYQLVGDEIRGYDTLGNVLTYFNAYDKKELAHNIYKGH
>NZ_CP046028.1|WP_107363795.1|83915_84875_+|amidohydrolase
MSDVKAIDTHAHLWSEAYLEKLGALGSQGTEVAKGIHQSESDDDLNKRFKMMDDAGVDLQILSATPQSPQWGTKEEAHQSANEINTLYEALVEKHPDRFLAYGAVSLPYVDQAIEEAKALLKKDAFVGIAIPTLVKDKVSIADHQFEDFFKAMNALQATLYIHPTGCGAQSPLINDYGLEWVIGAPLESTFITLHLIKNEIPQKYPNIQFHISHLGGALPFFMTRIKDNYEDWNAFNADPYELLNRQFWFDTANFQGSSLVNAIETFGEDKFMMGSDFPYFQDEKYTRGVQYIKESGLDMEAVEGVLRGNAIQFYNFNH
>NZ_CP046028.1|WP_103159031.1|82492_83836_+|multidrug-efflux-MFS-transporter
MIGAFIGVLNQTLLATILPEIMHDFQISSNTVQWLTTIFMLVNGIMIPVTAFLIERFTLRQLFFTATGFVVVGSFLCFIGPNFSILLVGRAVQALGAGMLMPLTQTLLFIIFPPEKRGLAMGMFGLVIGFAPAIGPTASGWFVNFFDWRYLFLIVLLIAVADFIFGYVTLQNMTQLTHPNFDVLSVIETTLGFGGLLYGFSVAGQLGWTHPVVYVTLILSIVILILFVLRQLRLETPLLEFRVFKYRNFTISMMLIILMFMLFIGSMTILPIFMQNTLHWSPLLSGLILLPGGLVMGLLSPVMGKVFDKMGGRSLSILGMSIILIGALLLAQIHVSTPILYIIFSFSVMMLGNAMIMTPMTTAALNALPMKYIAHGTAMNNTMRQISAAIGTGLLVTAMTSLAQGTSRSGTASVVFGLNMTYYIVALVALIGVGLAFFVKNEVPTTK
>NZ_CP046028.1|WP_151364416.1|81716_82250_+|anaerobic-ribonucleoside-triphosphate-reductase-activating-protein
MSALDIVEGRGYIAKIEQQSFVDGEGVRVSVYVSGCPFQCEGCYNVAAQKFTYGEPFTDEVLSEILKACEPDYIAGLSILGGEPFCNVDITLKLAEAFRKRFGPRKTLWVWTGFLLEYLARDTGLRYQLLSLIDVLVDGPFIQPLYQPNLAYKGSLNQRVIDVPQSLESGLPLSYIE
>NZ_CP046028.1|WP_145399881.1|79867_81730_+|anaerobic-ribonucleoside-triphosphate-reductase
MKQLEVALQGLITKDPTVVNENANKDSNTFSTMRDLTAGVVSKSYALEHLLPQRVAEAHINGDIHFHDLDYHPFQPLTNCCLIDAESMLAHGFEIGNANVTSPKSIQTATAQLVQIIANVSSSQYGGCTVDRVDELLSTYARHNEVHHREVAEQFVKAEAQEAYIDQQVTKDIHDAIESLEYEINTLYTSNGQTPFVTLGFGLGTDALSRKIQTAILKTRIKGLGKNRMTAIFPKLVFSIKKGVNFSKDDPNYDIKQLALECSTKRMYPDILNYDALVDILGDFKAPMGCRSFLPAWRDAEGHFENNGRCNLGVVTLNLPRIAIESQGDKHAFWQLFHERMDLLHEALLYRIERVLQATPQNAPILYKSGAFKYKLQAEEAVAKLFKHQRATVSMGYIGLYEVATVFYGPNWETNAEAKAFTLEILKEMKDYQEQWTEETEIWFSIYSTPSESLTDRFCRLDYEKFGAIPNITDKGYYTNSFHYDVRKDVTPFEKIDFEKDYAHYASGGFIHYCEYPKLNHNLKALEAVWDYAYDKVGYLGTNIPIDRCYECGFEGDFETTAQGYTCPHCGNHDPKTIDVVKRTCGYLGNPVQRPVIEGRQKEICARVKHLKETDPHERS
>NZ_CP046028.1|WP_145399879.1|78688_79612_+|lactate-dehydrogenase
MKLGIIGVGKVGSQILTDVQSTNLFSSIVVIDSNETLAYGEVLDHHHTQGLKTTNHIEIIQGTYDDLKDADVVAVTASVPMDPEISDRTALTKGNISLIEDIMNQINAVTQQPLVIFISNPVDAMTYIATQANDYPNEKIMGTGTLLESARFRTLIADHYDIDPKSVEAFVIGEHGKNAVPVWSKVTISGMSLTEFETLSQKPAINKEAITQKVDKVAFDVLKNKGWTNAAISKTTVDLIKRLMLNEKSILPLTSLNEEKALAIGLPTLTNRSGVAHVFDIELDADERTHFEQAEKYIKATIDVKNQ
>NZ_CP046028.1|WP_145399877.1|77629_78523_+|5'-nucleotidase,-lipoprotein-e(P4)-family
MNKWTKTATTLLALGVMTSTVPANTFAGTQQAPTQQTQAQHEHDYAKQLGDQNVMSVAWYQNSAEAKALYAQGYNSAKETLSKKIKHHKGGKKLAIVLDIDETVLDNSPYQAASTLKGQSFPTGWHEWVKSAQAKPVYGAKDFLTYADKHDVEIFYVSDRSHEKDLDATIKNLKKEKLPQADKKHVLLKKEGDKSKEERRDKVRTDYNLVMLFGDNLLDFDEPKSATPKSRDELVRQHEDEFGSKYIIFPNPMYGSWEATLYNNDYSIDAKQKLEKRKQSLKYFDMKTNKVKTYQGE
>NZ_CP046028.1|WP_107363800.1|76180_77332_+|N-acetylglucosamine-6-phosphate-deacetylase
MSYAIVNGSIYTETGRIPKGYLIIENDTIKEIKEGPYTGDLETIDAEGQHILPGFIDIHIHGGYGEDAMDASYTGLQHLASQLLSEGTTSFLATTMTQSTQAIERALKNIVKVQHDQKGTEAADIIGVHLEGPFISEHKIGAQNPKFIQRPTPDQLQHLQNVAQGQIKIVTIAPEVEGAEETIKAMKNDVIFSMGHSEVTFDQANHASEIGVKHVTHLYNAGTPFVHRDPGMFGAAWLNPNINCEIIGDGVHSHPASVKIAYKQKGADHLYLITDAMRAKGMPDGCYDLGGQDVIVKDNEAHLKTGSLAGSILKMNEGLRNLMAFTEDSLETLWRCTSFNQAQVLGIDDQKGSIKEGKLADLVILDEHMDVKQTIKSGCVHQF
>NZ_CP046028.1|WP_105986918.1|75755_76151_+|PTS-sugar-transporter-subunit-IIA
MEKLILVSHGSFCEGIKDSVEMILGPQENIYTVALTPEQGQEDFESHFKALVHEGDDIVVFADLQGGTPANTVSKMIMQGEQYQLYTGMNLPMIISYINAQMIGQEEDYAQKAKDGIIHINDLLTSDDEDE
>NZ_CP046028.1|WP_165885333.1|91141_92890_+|hypothetical-protein
MKKVRDTYWNKSNHLSRSLKMSSATLIIITGILGNQFTPIAHAEQVTQGERPTSLEAYIQKSQADIQKLKTLSAQQKAQLNTDIHQAQSIDEIDRLLKEAHVELLSTEEGNQASSLRQSPSEMNQKLEELRSNHEQINQNIDRFFTEVDSSTHKVDGGKLSDVNLNDDATLSARHLAETLNQKEPDTSNLKKNLHQLLSVSDENQGALDHYVATKEEGLKAFESKLATEPNLSEERKALLNKEIQSIQRELNEQNDVVHQRLNTADNKPEAVRALIGETLNDKEAANVLKRIQTDGKSNAQIANQIVSQLDRFTTLTSDDLLRSMLENTTQRKDLIETLLSTRFDSTEASKIADDILKGNPTNAQILERLKQRYGPDMTADDILENVFDQAHNQRQALETILKSKFSPDVAHALAERLENKANARGELLKLLKSDADTHLNKLIKANNDIQRLKSKIHGMFNPLDRMQDLFNPSHSRLLEGGLLRGQSNLFNPLGLLDQLLNGKSLLDNIPDLPNPTQGRALSLLKPTDSFLSGLFDHNGNFDLPAAGQIAKQRLLPLGILMIVIGGFLFWGLKRRHSHKSS
>NZ_CP046028.1|WP_165885334.1|92942_94973_-|amidase-domain-containing-protein
MKTQKLLICMLSSTLVLPSLPVSHVHAETVKHISETPQSEETPSDETTSSNEKSKTEKQSSSNKKEENTKSSKTKDTPRATQKEQRDEDSSRPSSYLNDHFSNDYDFINPSPFKSLSLSNMWHTWFSSDHQATESEQPSTETPSSEAPTTENTTSTDEAQSAPTSQAESSPETPATESTPSRDNSHLSESDKAIADELDRISDSTAPSQTSDEQNHTSQEPSSTEETTEPSTTQGATEETSETPETNADTDVSSNETPSTEAETSQPSSDEDASASSSDDHVIDAVLDEYSEKSKDTASHYENQKNQITETSKDQSNTQTKNPQLPSEEAYQKRETPKQSFEDDFKDANLRSTATFETLPGFSGSDDSQDFVIAENKNTRDFIKKIAKDAHDIGQKEDIYASVMMAQAILESNSGNSALARAPHYNLFGIKGAYKGQSATFNTLEDNGGQMYQISASFRSYPNQKASLQDYADLMKNGIDGNPDIYKPTWKSEAPSYRSATEHLSTTYATDSHYADKLNSIIKHYDLTRFDKKQMPDLTHDTTTPEEAGSDYKPFVETDGTSPYPHGQCTWYVYNRMAQYGLHIGGDLGDARNWDNRAEDDGYDISMTPKAHSAVVFEAGQQGADSVYGHVAFVEKVNRDGSIVISESNVKGLGVISYRTIDAQEAKDLTYIQGKH
>NZ_CP046028.1|WP_165885335.1|95183_98012_+|YhgE/Pip-domain-containing-protein
MKNAIKLFLMDLKKIMKAPAVFVILAGLSLLPSFYAWFNLDATWDPYGNTKNIKIAVVNEDEGDKVRGKHINVGNTVVDQLKKDDHFDWEFVSREKADHDLKMGKYYAAMYIPKPFTHEITGTLRKKPQRANIEYKVNQKLNAIAPKMTDAGTSAIVQKANDKFNETVTKALLKEANRLGVKLENEIPTINKIKDAVSTANHAVPKINEIAKKVLYLDSHQDEIDQYANEFRNLGRHKGDVLNAVDKLNQVNAAVPALNERAKLILALDAYMPNIKRALNVASNDVPNAFPRINRGVDVASQGVDTGLQGLNDAESYLNAIDQRLQRIQGNVQNAQNTNQNVTNRLENNVQTAPQSASAHQHIQTAQMSTSSSDAPSGSPYDANDLNAMESALSKALLTMSQQADTQAESSQKDISALKNVLYGVLSSDQPKDFVPTLDHLKSRLELTSQTNQQLIDTMKELENKEGIDLSAPIKELESTNNQVNNVIKKLNQLSTSLSNGSTGKAEAVDILKALPDLNDTLGQLRQYIQSDLNQILVDVSKTITAALADGNQKLSTVQSKLDTIHQVIQDGQSLLTTVKERLNVIQSELPLIEQRYMDAMAVAQRYYPTLENNVSRAASFVRNDLPRLEQRLADTTATVNQNVPALFSRYDQLVQLLDENQPQAKQQLHLLAQFIRNDLPGVERDLAKADKLFKEIDKNDTVDRLVDLLKNDLKKQADVIANPIKINQEDIFPVKDYGSASTPFYTALAVWVGALLMVSLLTTDNKHKELDSILTKRQIYLGKLGLFYLIGTIQALIVSIGDIVILNAQVESVPWFIGITVLSSFVFVTIVYTLVSLLGNPGKALAIILLVLQIAGGGGTFPIEVTPEFFQKLHPLIPFSYAIDALREAVGGYVPAILTQKLVILIAFGLVFLIIGIILKPITDPIMRKVAERAEKSEVME
>NZ_CP046028.1|WP_103159608.1|98078_98663_-|TetR/AcrR-family-transcriptional-regulator
MNKQDLRVLKTQKALMQAFTDLLKTKEFDRITVQDLCDVAVIQRSTFYRHYNDKYHLLASATKTALEHIKQAQISEQHAQNHRLRLEQYIDNLLTFVCENKAIIQHVISHNLHDEVTTIIYKQVYQTVYQQTLADMRAGKQLDINLNIYSHFLAGGLISIIINWTYTSDNLQSVESVKSNIVALMDSARKAHLK
>NZ_CP046028.1|WP_145399897.1|98827_100603_+|oleate-hydratase
MYYSKGNYEAFARPKKPENVEKKSAYLVGSGLAALAAACFLIRDGQMQGSQIHILEELPKPGGSLDGDQLPMKGYVVRGGREMENYFECLWDLFRSIPSLEIKDASVLDEFYWLNKEDPNYSRCRVIEKQGHELPTDGDFKLTSKAQKEILKLCLTNEEDLNDVKITDVFTQDFFDSNFWTYWKTMFAFEPWHSAMEMRRYLMRFVHHIGGLSDFSALKFTKYNQFESLVMPMVHYLRDHNVQFEYDVEVEDIKVDVTTSQKVAREIVMKRDGKRESISLTPDDLVFVTNGSITESSTYGDNDTPAPPTEEIGGSWQLWQNLAKQSPEFGNPEKFYRNIPKKSWFVSATATTSNKTVIQAIEKLCKRDPLAGKTVTGGIITVDDSNWQMSFTVNRQQQFKSQPKDQVSTWIYALYSDVNGDYIKKPNTECSGHEICQEWLYHMGVPVDQIEQLAKEEVNTIPVYMPYITAYFMPRAQGDRPLVVPHQSRNLAFIGNFAETERDTVFTTEYSVRTAMEAVYQLLNIDRGVPETIGTEFDVRELMNAMYHLNDRQSLDEVMQDSKVQRTLLKGVKRKIKGTYVETLLKDYHLL
>NZ_CP046028.1|WP_165885336.1|100708_102340_-|hypothetical-protein
MKIQNISRLLMGAATITLATMVANGEAKASEETPTQSPVQQTQQTPVQQTQRAQATFDSQHVSDAQRAFYHTLHINGITDSQRQGYIKQLRQNPNHETTAQNVFSESTKDSNNPDRRLAQRNAYFEIIHNPKLSSQERERYIGQLIENPDHSQLIWIESNRVPSGNSGNTASEADFLNFTQSKPLQLNQHTPKYQQKHHLPSQNQYNTATEAEFEKFVYPNHNIKLEHQQKHHKYLTNLNRDNTLVDEDLHKIIDTFKPIPVAQNAKAETPSVKLAPLFPYKDLSNEEIFSHLRHLRDTKQISNADLESLLKWFPPIGVNQNKTVQLSTLFPDNNLSGERLLNDLRELYKVNRISKADLEKLLSYFPPIPVKNEASATNGQTQSATSAVKTSTAHVAQAPKVTPSVQSEKASTSYYQSVKNFFSESYNKIANTFNGYKTKYENTKYYVSTYFKYKNTIDKFVLTTLGDGASSHIRPLKVRPNDNVAYNALLHARNFFTEGINTGKVLHAFYKHPTTVKNVIATADTASALKNIASAFVSNWWK
>NZ_CP046028.1|WP_103159605.1|103095_103926_+|CPBP-family-intramembrane-metalloprotease
MKWIKVLCLVIIGFLIMALGQAVASIWDVFIPYYGIGALLFGITYILVSLWMIRLIIKKVFKEDLVDYRITPFKWNKTAFLIALALPIGIYAVYILFVPGEWITHLNGSNSELLNQLSWSIFVNAMGAAVVEECICRGLLMGYIEKQWNIQIAIMMTSVFFASIHLLNGVSDFYDVLLLLMSGSLVGFMFGLLVYVFKTIWASIIVHFFWNLFQVIQFSTNPHEAAPLIYLMKLQVRWITGGDYGIETSVISILGYLMVIMILMFYYFKQREQRIH
>NZ_CP046028.1|WP_165885337.1|103975_104863_+|alpha/beta-hydrolase
MKNRGGYVKKRIIGLSILLVAVLIIAVIAVSLFQKRAHWEEQNKKQYVQAPTPTLFLHGYGGTKNSMKYLINQAEARGVTKDIVVAHVSRDGDVTFDGKISKGATNPIVQIVLDDNTQGDLNENALWIRQVLEKLQHDYHVKQFNFVAHSMGNVSFAQYMVDYGRDTSLPQLKKEVNLAGTFNGVLGMNEEVNEIQVDRNGKPSHMNPPYQEFMQLKSIYKDKNIDVLNMYGDLLDGTHSDGRVSNSSSKSLKYLLGDSPKSYQEVKYEGKEAQHSALHENEEVAQQMIRFLWGK
>NZ_CP046028.1|WP_103159643.1|105084_105582_+|hypothetical-protein
MYKVAKVFLATSILITGVSFTALPTESNVAQAAVTPYYTYNGYAGYNAKFVTDKTFINALRYNNITMNNVKVDAKIRKFEASNDYFFKKKYDQVIEYINHKPTAITFSVTNKSLKLSDVKKAYAKYQMSSDKVHRAIIYNVNGQQISFVYNGNDVTSVIIGRYHS
>NZ_CP046028.1|WP_165885338.1|105683_107123_-|6-phospho-beta-glucosidase
MSKLPKDFLWGGALAANQFEGGYREGGKGLSVIDVMTSGTHETPRQITKEIHPHLYYPNHEAIDFYHHYKEDIALFANMHLKCLRTSIAWTRIFPNGDEEEPNEEGLQFYDAVIDELLKHHIEPVITLSHFEMPLHLAQEYGGFRSREVVHHFVKFAKVVFERYQHKVTYWMTFNEINNQMETRHPIYLWTNAGVLLQKDENPEEVMYQVAHHQLIASALAVKVGKSINPNFKIGNMISHVPIYPYSCHPKDMMEAEINNRLRFFFPDVQVRGYYPNYAQKMFEHKQYHIGILEGDEEILAEGTVDFIGFSYYMSTTVQHHKTLTSNEHEVFGDLLNSVPNPYLEKSSWGWAIDPIGLRYTLNTLFNRYQIPLFVVENGLGAVDEMDDNGQINDDYRINYLRQHIQAIVEAIDMDGVDVLGYTPWGIIDCVSFTTGEMKKRYGLIHVDRDNDGKGTLKRTRKKSFYWYRDVIDSNGQNL

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Crispr_ID: NZ_CP046028_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046028_2

159299-159731

TypeII

Consensus_repeat	Method
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	PILER-CR
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	CRISPRCasFinder
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	CRT

6 spacers

cas9,cas1,cas2

The CRISPR arrays of NZ_CP046028_2

>merge|NZ_CP046028|2|159299-159731|PILER-CR,CRISPRCasFinder,CRT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTCTCTAACTGCATTCTCCAGCGTCCTTGATGAGTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTCTGGCCAGAACGAGCAAAACAACAAGGCTACGTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTCTTAGTGAAAGAAGAGGACAAAGAAGAGGCGGTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTCCGTTCCCACTCAGCAATTGCCCCGACAAGCGTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTCTCTCTCCTCGAAAAATTGGAGGAGAAAGGTGTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTCCTTCATTTGGCTTGAATGATTGGATAACTACGTTTTAGTACTCTGTAATTTTAGGTATTTTTAGCAT

>NZ_CP046028|2|1|159299-159664|PILER-CR
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	TCTAACTGCATTCTCCAGCGTCCTTGATGA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	TGGCCAGAACGAGCAAAACAACAAGGCTAC
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	TTAGTGAAAGAAGAGGACAAAGAAGAGGCG
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	CGTTCCCACTCAGCAATTGCCCCGACAAGC
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	TCTCTCCTCGAAAAATTGGAGGAGAAAGGT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC

>NZ_CP046028|2|1|159299-159731|CRISPRCasFinder
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	TCTAACTGCATTCTCCAGCGTCCTTGATGA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	TGGCCAGAACGAGCAAAACAACAAGGCTAC
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	TTAGTGAAAGAAGAGGACAAAGAAGAGGCG
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	CGTTCCCACTCAGCAATTGCCCCGACAAGC
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	TCTCTCCTCGAAAAATTGGAGGAGAAAGGT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	CTTCATTTGGCTTGAATGATTGGATAACTAC
GTTTTAGTACTCTGTAATTTTAGGTATTTTTAGCAT

>NZ_CP046028|2|2|159299-159731|CRT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	TCTAACTGCATTCTCCAGCGTCCTTGATGA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	TGGCCAGAACGAGCAAAACAACAAGGCTAC
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	TTAGTGAAAGAAGAGGACAAAGAAGAGGCG
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	CGTTCCCACTCAGCAATTGCCCCGACAAGC
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	TCTCTCCTCGAAAAATTGGAGGAGAAAGGT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	CTTCATTTGGCTTGAATGATTGGATAACTAC
GTTTTAGTACTCTGTAATTTTAGGTATTTTTAGCAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046028.1\|WP_037576676.1\|153297_153924_-\|FMN-dependent-NADH-azoreductase	unknown	unknown	gnl\|CDD\|234675
NZ_CP046028.1\|WP_107363653.1\|155367_156951_+\|acyl--CoA-ligase	unknown	unknown	gnl\|CDD\|341276
NZ_CP046028.1\|WP_165885360.1\|150802_151552_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046028.1\|WP_107367998.1\|151574_152477_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP046028.1\|WP_165885364.1\|167858_169208_+\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	unknown	unknown	gnl\|CDD\|273109
NZ_CP046028.1\|WP_165885361.1\|154159_154480_-\|SPIN-family-peroxidase-inhibitor	unknown	unknown	unknown
NZ_CP046028.1\|WP_165885359.1\|149894_150803_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP046028.1\|WP_105967372.1\|152537_152972_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|225356
NZ_CP046028.1\|WP_165885358.1\|149143_149812_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP046028.1\|WP_037576666.1\|157907_158549_+\|hydrolase	unknown	unknown	gnl\|CDD\|238494
NZ_CP046028.1\|WP_107399113.1\|171041_172634_-\|L-lactate-permease	unknown	unknown	gnl\|CDD\|224535
NZ_CP046028.1\|WP_107367024.1\|167191_167884_+\|dethiobiotin-synthase	unknown	unknown	gnl\|CDD\|223210
NZ_CP046028.1\|WP_145399957.1\|164336_165341_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046028.1\|WP_037576664.1\|158636_159059_-\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|107228
NZ_CP046028.1\|WP_165885363.1\|165617_166940_-\|Nramp-family-divalent-metal-transporter	unknown	unknown	gnl\|CDD\|234815
NZ_CP046028.1\|WP_107366678.1\|164014_164323_+\|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0206_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|226043
NZ_CP046028.1\|WP_145399955.1\|163107_164010_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851
NZ_CP046028.1\|WP_037576653.1\|170314_170995_+\|6-carboxyhexanoate--CoA-ligase	unknown	unknown	gnl\|CDD\|179280
NZ_CP046028.1\|WP_165885362.1\|159940_163108_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187774
NZ_CP046028.1\|WP_165885365.1\|169209_170322_+\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223234

Protein	Function_ID	Function_description	E-value
NZ_CP046028.1\|WP_107363653.1\|155367_156951_+\|acyl--CoA-ligase	gnl\|CDD\|341276	cd05972, MACS_like, Medium-chain acyl-CoA synthetase (MACS or ACSM). MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes.	0
NZ_CP046028.1\|WP_107367998.1\|151574_152477_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.19911e-27
NZ_CP046028.1\|WP_165885364.1\|167858_169208_+\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	gnl\|CDD\|273109	TIGR00508, hypothetical_protein_DESPIG_00326, adenosylmethionine-8-amino-7-oxononanoate transaminase. All members of the seed alignment have been demonstrated experimentally to act as EC 2.6.1.62, an enzyme in the biotin biosynthetic pathway. Alternate names include 7,8-diaminopelargonic acid aminotransferase, DAPA aminotransferase, and adenosylmethionine-8-amino-7-oxononanoate aminotransferase. The gene symbol is bioA in E. coli and BIO3 in S. cerevisiae. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin].	0
NZ_CP046028.1\|WP_037576676.1\|153297_153924_-\|FMN-dependent-NADH-azoreductase	gnl\|CDD\|234675	PRK00170, PRK00170, azoreductase; Reviewed.	3.85483e-107
NZ_CP046028.1\|WP_165885359.1\|149894_150803_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.19604e-75
NZ_CP046028.1\|WP_105967372.1\|152537_152972_-\|VOC-family-protein	gnl\|CDD\|225356	COG2764, PhnB, Uncharacterized protein conserved in bacteria [Function unknown].	7.43935e-27
NZ_CP046028.1\|WP_165885358.1\|149143_149812_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.25592e-67
NZ_CP046028.1\|WP_037576666.1\|157907_158549_+\|hydrolase	gnl\|CDD\|238494	cd01012, YcaC_related, YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.	3.04248e-63
NZ_CP046028.1\|WP_107399113.1\|171041_172634_-\|L-lactate-permease	gnl\|CDD\|224535	COG1620, LldP, L-lactate permease [Energy production and conversion].	1.47214e-103
NZ_CP046028.1\|WP_107367024.1\|167191_167884_+\|dethiobiotin-synthase	gnl\|CDD\|223210	COG0132, BioD, Dethiobiotin synthetase [Coenzyme metabolism].	3.60876e-50
NZ_CP046028.1\|WP_037576664.1\|158636_159059_-\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|107228	cd06471, ACD_LpsHSP_like, Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits. Transcription of the genes encoding Lp HSP 18.5, 18.55 and 19.3 is regulated by a variety of stresses including heat, cold and ethanol. Early growing L. plantarum cells contain elevated levels of these mRNAs which rapidly fall of as the cells enter stationary phase. Also belonging to this group is Bifidobacterium breve (Bb) HSP20 and Oenococcus oenis (syn. Leuconostoc oenos) (Oo) HSP18. Transcription of the gene encoding BbHSP20 is strongly induced following heat or osmotic shock, and that of the gene encoding OoHSP18 following heat, ethanol or acid shock. OoHSP18 is peripherally associated with the cytoplasmic membrane.	1.63617e-39
NZ_CP046028.1\|WP_165885363.1\|165617_166940_-\|Nramp-family-divalent-metal-transporter	gnl\|CDD\|234815	PRK00701, PRK00701, divalent metal cation transporter MntH.	0
NZ_CP046028.1\|WP_107366678.1\|164014_164323_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	6.27556e-30
NZ_CP046028.1\|WP_145399955.1\|163107_164010_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	5.10016e-94
NZ_CP046028.1\|WP_037576653.1\|170314_170995_+\|6-carboxyhexanoate--CoA-ligase	gnl\|CDD\|179280	PRK01322, PRK01322, 6-carboxyhexanoate--CoA ligase; Provisional.	5.17205e-89
NZ_CP046028.1\|WP_165885362.1\|159940_163108_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|187774	cd09643, Csn1, CRISPR/Cas system-associated protein Cas9. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Very large protein containing McrA/HNH-nuclease related domain and a RuvC-like nuclease domain; signature gene for type II.	2.2599e-121
NZ_CP046028.1\|WP_165885365.1\|169209_170322_+\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	gnl\|CDD\|223234	COG0156, BioF, 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism].	9.36997e-108

>NZ_CP046028.1|WP_037576664.1|158636_159059_-|Hsp20/alpha-crystallin-family-protein
MAFQMKPFNNSIFDMNPSDLFRDFGQGLLNTNDFKTDITERDDAYIVSAELPGMDKSDISVDFNNNILTIAASHSEDNKEENDEGVIIHRERHTSSVKRQFSFNDVRRDNIEASYDKGVLHITLPKNQNENDSSSRITIN
>NZ_CP046028.1|WP_037576666.1|157907_158549_+|hydrolase
MAKNQDLYQRLNKDDAVVLLVDHQTGLISSLVRDYGVDEFKNNVVALAETAKFFDLPVILTTSFEEGANGPLMKEITDIFPDATKIPRPGQINAWDNEDFVEAVKKTGKKQIIIAGVVTDVCVAHPALSAINEGFEVFAVVDASGTVSKQVADAALMRMQQGGVQLTNWFSVASELQRDWRNDPDGFGALLTNNLPGYQNVMGSYLAAQSQQK
>NZ_CP046028.1|WP_107363653.1|155367_156951_+|acyl--CoA-ligase
MNKAELVAPKNYNIVDEIEKHSQNPQKLALIYEKGFDAPEKVTYTELIKQANRVGHVLTKSGLKKGDRILVMLPRAIETYEIYIAALKLGLTIIPSSEMLRTKDLQYRITHGSVAAVITMPEYIKEFERVEEYETLIKLLANGEHEDWTAIASEKMKQPEELESVSTTRDDLAILSYTSGTTGNPKAVMHTHGWGFAHMQLAPKQWLNIQEDDLVWATAAPGWQKWVWSPFLSIMGSGATAFVYNGKFKASRYLELLQDFKINVICCTPTEYRMMAKLNNLDSYDLSHLRSAVSAGEPLNRDVVDKFEQHFGLTVRDGYGQTESTLLIGFLEDTPKRPGAMGKAIPGTGVTIIDDDGTELGPNEEGNIAVPLDLPALFKGYLNDEARTKEARLAGYHITGDLAQKDADGYFWFEGRKDDIIISSGYTIGPFEVEDALTHHEAVKECAVVASPHPERGNIVKAFVILQEGYEASDALIHDMQQFVKQSVAPYKYPRAIEFVDHLPKTNSGKIRRVVLRNEEKKKHQSK
>NZ_CP046028.1|WP_165885361.1|154159_154480_-|SPIN-family-peroxidase-inhibitor
MNVNKVILTAVTIGVLATGLFVAVPHEKADAAVKSQNGIVLQDDSRILEHELDYVGIIVDKKADKKIKANLKAYLKLQGCNSVSDFVKKAKSQGLDTSKYDYLIKK
>NZ_CP046028.1|WP_037576676.1|153297_153924_-|FMN-dependent-NADH-azoreductase
MSKLLYITAHPLDELVSNSMAAGTAFIESYKENHPEDEIVHIDLFKDYIPFIDGDVFSGWGKLQNGEALTSEEEKKVSRLNELSDQFVSADKYVFVTPMWNLSFPPVMKAYIDSVAVAGKTFKYTSEGSVGLLTDKKALHIQSRGGYYNEGPAKDLEHGDSYLRAMMTFFGVPTYENVIVEGHNKAPERSEEIKSAAILKAKELGQTF
>NZ_CP046028.1|WP_105967372.1|152537_152972_-|VOC-family-protein
MKAVTYFNFGNALEALTFYEEKLGAEIVSKTMGDDEMFKNLPEEYKMPDEVAKRFVMNAEFKILGQHFMVSSTQGERPVNNEGMNVCFTFDGNDEEDVKAATTFYQRALDAGCQETMPLGETEWSKLYGMFQDPFGVTWMINAC
>NZ_CP046028.1|WP_107367998.1|151574_152477_+|HAMP-domain-containing-histidine-kinase
MAYGIGAVLVVIIVFLGLRYFRLKKEVEYFTQQLIKINQDVETNQYMRSATGLKQSQALLNELNTYMNQLRNYRYFYRKKELMLNKEINNVSHDLRTPLTAIKGYTEIIKETDNKEELLKYIQVIDEKTTHLIKSVNLFHELTYLNAFDYELDLETMDIVEFIKAQFMSYFKQFDNKGIQITFENSNVLEVLAHKEAMIRVVNNIIQNVLRYGKNQAKVRFVETQEFINIHIENDTEYRMNDAQVQKLFERAYTLDESRTNQTTGVGLYIVKNLLERQRGQVSLQFEKPMFAIIMSLRKV
>NZ_CP046028.1|WP_165885360.1|150802_151552_+|hypothetical-protein
MINLLKSQCYLILRTKKFYIFAIICFLLIILAGVVLYVSGKQEATFPYDNARFYYINVLGFSGLLILLCIMVNQFVHSKEFQQSEKVSIAYDISKQAIYFGKFLAVLCYFSIVSIIAYVILLTLGINLFEDGWRYSLDITISFLNMAPIIFGALATSHALYSSRYKTIGVLMWILFIFLFSKQIFYGLMTLNKAFAPIYRLTPQYLLDQNMQMYMLDKVHIDLKCWLVGLSIGIFSLILGYVKFKKVEY
>NZ_CP046028.1|WP_165885359.1|149894_150803_+|ABC-transporter-ATP-binding-protein
MSDVIETKQLCKKYDNQFALYPVDFTLKKGEICALIGRNGAGKSTFIKLIANQISPSDGQIKLFGKSDKVKNEMRKRIGFLIDTSVFIPQFNAKQNLEYFAIQNGGVNQSHIQDVLLKVGLGEETKKVKSYSLGMKQRLGIALALLNGPDVLVLDEPINGLDVEGIRDFRNLVIQLNKEYGITILIASHILSELQQIATQFVFIEKGKIVESVSRDVLFKKVTKSILIKVDRTSKAVQVLDFCDKNLEYKVLSDDTISIKSNVMNASEINDLLWKSDIRVYQIQEKGFDLEDYFFIEERGEI
>NZ_CP046028.1|WP_165885358.1|149143_149812_+|response-regulator-transcription-factor
MKYKALIIEDNVEIAHIISLYLARLDTQSTIVYTGRDGLEKVQSEVFDLIILDLMLPEKSGDEIIEDLKQLSQARVIVVSAKSEVNDKVNLLLLGADDYIIKPFDKEEFSARIQVQLRNIRTESSNRTITWKGLKLNKTKRCLTLNDHTIELTNTEFDLLKLLMSKPETPFTKKQIYESIQGMYIGDDNTINVHISNLRKKLAQYSNDSYIKTVWGIGFMLV
>NZ_CP046028.1|WP_165885362.1|159940_163108_+|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MTNYILGLDIGITSVGYGIVNSETREIIGAGVRLFPEADVNNNEGRRSKRGARRLKRRRIHRLERVKQLLAEYELLNSSSIPQSTNPYEIRVRGLRNELSKDELVIALLHIAKRRGIHNVNVVIDDNESNNELSTKDQLKKNAKALEDKYVCELQLERFKQEGKVRGERNRFKTEDFVKEARQLLKTQTQFHPIEQNFIDQYIHLIETRREYFEGPGEGSPYGWEGNIKKWYEQMMGHCTYFPDELRSVKYAYSADLFNALNDLNNLVITRDEDSKLNYGEKFQIIENVFKQKKTPNLKQIAKEIGVNETDIKGYRVNKSDKPQFTSFKLYHDLKEIFEHTEYLKDAQLMDNIAEIITIYQDPESIISALNELPELLTENEKQQISQLTGYSGTHRLSLKCINLLIDDLWESSLNQMELFTKLNLKPKKVDLSRQNKIPTNLVDEFILSPVVKRAFIQSIEVVNAVIEKYGLPDDIIIELARENNSDDRRKFLKKLQKQNEETRKLVEKVLKEYGNDNAKRMVQKIKLHNMQEGKCLYSLKDIPLDDLLRNPTHYEVDHIIPRSVAFDNSIHNKVLVRAEENSKKGNRTPYQYLNSSESSLSYKEFKQHILNLSKTKDRISKKKREYLLEERDINKFDVQKEFINRNLVDTRYATRELTSLLKAYFSANQLDVKVKTINGSFTNYLRKVWKFDKDRNKGYKHHAEDALIIANADFLFKHDKKLKNVSKILDAPGQEVDSSRTSVQSEDEFNEMFENTQKATAIQKFEIQKFSHRVDKKPNRQLINDTLYSTRNIEGTEYVVQTLKNIYSKDNKDVKKLIEKDPSKFLMYQHDPKTFEKIQMIMKQYSDESNPLAKYYEEKQEFITKYAKRGDGPPVKALKYIGKKVGIHLDVTSDYENSKNKLVKLSKKSFRFDIYQTPEGYKMVPITYLDIKKKDTYFVIPHEVYKNILSRKKVDDTARFVGSFYYNDLIKFEDNIYKVLGVNDAEGNIIELDMVDIKYKEFCELNDIKSTPRIRKTIGKSTTNIEKYTTDILGNLYKATPPKKPQLIFKRGME
>NZ_CP046028.1|WP_145399955.1|163107_164010_+|type-II-CRISPR-associated-endonuclease-Cas1
MSWRIVYASDVSKMSLNLNSLKVTKGDLEVKIPLSDIFAVVIEDLTVTLTARLLVELSDYNILVILCNQKHLPECMLQPISGHFSQYGQMKEQLSWNQAQKDELWKRLVQQKISNQIECMRHVQVNPIRIEKMQQLQASVKLFDRENIEGQAAKYYFNSFFTGFTRDNDDLLENAVLNYGYTILNSAIARTIVAKGLIPAIGIHHIGGRNHFNLASDLIEPFRPLVDLFLLKHPPEDFMTKSYRLNLVNLLHARIEIDGKMQTVIRAIDIMIQSMIEYFREGRIDLLKFPNLYKYEFYEL
>NZ_CP046028.1|WP_107366678.1|164014_164323_+|CRISPR-associated-endonuclease-Cas2
MRVLLMFDLPVETKQQRRIYSKFRKRLLENGFLMMQYSIYIKSVANKDAANFSVNQVKQFLPPDGHVRVLIITEKQYEKMQILLGEEDQNIALLGDNRTILF
>NZ_CP046028.1|WP_145399957.1|164336_165341_+|hypothetical-protein
MNEMTWEIKCEDFENVTLNIGQYTSIYNEHDTKEEDILKVIHHYFQKRNSNKNEVIIYDTQNQETVSHASYQCWTLNHEIIEKEHALATNAILTKKILRKLGNHLEMESYFNSINALHEDILATVQEELPLCVKRFDYKAFLKLLEFQYEVCEDYDRLIVRLEKLLPLLIEEMNALSNQRTLLIYQYPEANLSPKEQQRFRKCLENLGVPIIVLTGSTHFLSSKLTNNNYLRKGQQMLTKAFLHHLVWNAPLNFDENQIKHSLNAFIQLYQEKVELTPVISNYRLADIMLFDTIDLYVGITYMKHINQSYQLDINYHQLNDPMIKFIQSYDKTS
>NZ_CP046028.1|WP_165885363.1|165617_166940_-|Nramp-family-divalent-metal-transporter
MSKSLEDINNTVSFDDQGSYLSRLSKFIGPGLLVAVGYMDPGNWITSIGGGASYGYILLFVIFISSISAMFLQSMCARLGIASGMDLAQVTRHMISKKMAVIAWIIAELAIMATDIAEVIGSTIALNLLFHIPLIIGAVITIVDVFLLLLIMKFGFRKIEAIVGVLIFTILIIFLFEVYMAQPGVSDILKGFIPQKEIVTRNGILYMSLGIIGATIMPHNLYLHSSIVQSRKYDRNSVSAKKSAIQFAQIDSNIQLSIAFVVNCLLLILGAALFYGTSQDLGRFYELYDALKTSHVASAIGGGVTSTLFAVALLAAGQNSTITGTLSGQIVMEGFIHLKMQPWVRRVVTRLLAILPVFFCLLIYGANAQKIEDLLVFTQVFLSLALPLSMIPLILATNNKTIMGDAFINTRWVNIVGWLLTLVLCILNIYLIISTLMEMM
>NZ_CP046028.1|WP_107367024.1|167191_167884_+|dethiobiotin-synthase
MKIFITGTNTDVGKTYVVTRLWQWLNHRGISTVIFKPFQTEELEEGLYPDLEAYRTLCGLDYELTGLYTFHEAVSPHLAFKQEPHQQFDLNKVLSKLAYLETQYDVVLIEGAGGIAVPIYIENETFFMTTDLIKATADVVLSVVPAKLGAISETLVHQSYLDTHECPPNIILMNRYTDTVIEQDNRLTLQSYLKTPIVTFPENGKMTDIPETIFNYFKEVTFHETSNTRR
>NZ_CP046028.1|WP_165885364.1|167858_169208_+|adenosylmethionine--8-amino-7-oxononanoate-transaminase
MKHQTLVDKNLEYVWHPFTQMGVYRQQDPIIIEKGKGSYLYDTKGRRYLDGYASLWVNVHGHHNKRLNKAIEKQLKSIAHSTLLGSSNIPSILLAEKLVDITPRTLRKVFYSDTGSAAVEIAIKMAYQYWKNVDPVKYRKKNKFITLKNGYHGDTIGSVSVGGIETFHQIFNDLIFENIQVTCPSFYHSTYDTEEDLKEAVLNQIERVLRTRGDEIVGVVMEPLIQGATGLFVHPKGFLNGVEQLCRQYDVLMIVDEVATGFGRTGELFACEHEQVEPDIMCLGKAITGGYLPLAATVTSQRIYDAFLSDAHGQKTFFHGHTYTGNQVVCALALENIQMIEEKHLIRHIQKTSQVLEKQLRQLETLPHVGNVRGRGLMFAVELVSDRQKKSPLAIATVERIIAECKKRGLMIRNLEHIITFVPVLSMSKREVKKMTHIFKKVLEDILGD
>NZ_CP046028.1|WP_165885365.1|169209_170322_+|pyridoxal-phosphate-dependent-aminotransferase-family-protein
MQFQSYLEQLQQQDQYRQLREVKTARKQRLYRDGQAWINFTANDYLGLGQRSIKMDELERAIQKYGAHLGSSRLVSGHSTLYAEIEQDISEAYGFEGSLLLGSGYEANLAVFQMFKKQDVIIFSDALNHASIIDGIQLARVKKVVFPHLDYARLKMEMAKYPHQLKVIVTDTIFSTNGHMADLHQLRRLKSEFPGTLLVVDDAHGFGLGYGTGYENIDIVTTSLSKAMGAHGGLILCSYVIREMLINTARPLIYSNCLPTMNLFLIQEQFRALQNADFERRQLHQNIQYFNEMNENTEHTLTAIKTVTYENVHTAKAMHSQLLDSGFWVSLFRPPTVATPALRMSLSAFHEQEDIMRLHTILKKGDTPHV
>NZ_CP046028.1|WP_037576653.1|170314_170995_+|6-carboxyhexanoate--CoA-ligase
MYSIKMRASEDNQHISGAETICEAKDIEQVIAAYFHKGFQHENGDADFLNLKIEKITSPLVQLQALPIIEVQSQTFKQLALDRKITDKAMEQAWRYITNPTCYRGAIILDATTGERLDNFGERGCRVTHFCFQHQSSKSPLNERVRDALSIASIIQSNEGVVGEMCVSDDVNYTTGYFADAKGYHRLHNVKMKGSRVGGRIIFVNQKFQLESFLYFCQQQPKRVIY
>NZ_CP046028.1|WP_107399113.1|171041_172634_-|L-lactate-permease
MLMLVALSAVIVPFIFLVLLRMSALVGMTISAIVVTILGMFAWGIEAGVIAASFLQGIHKTLTIILILFGALTLLNTLRETSAVDRINAGFQNVSGDMRVQVIIVAFLFGSLIEGASGFGTPAMVTAPLMVALGFKPLTSVATALIADSVAVSFGAVGTPVIVGLSTLKNANAHLFSETAIRITMLDLLSGILIPSIIVITMIVFFGKSNKLKAILEILPWTLLIGVTYVLSALAYALLTGPEFVSILSSLTTIIVAVFTAKKGWLVPKNEWKDALSEVYESKPQTTHQMSLLSAWSPYLIVVALLLLTRVVAPVKAFTTSVFNLSWNNILGYESISSSWEVLYSPGTILVVAAFLAVLIQRKSMKNFTKACKDSIKTIRITGITLIATLAMVHVFSNSGINTKDLISMPEYIANGMASTFGQMWLFVAPFLGALGSFITGSATVSTLTFAPVQANIAAAIEGNTTTVLAAQIIGAAAGNMICVHNVVAVCAVVNMAGKEGSVIRKTLGPALLYCLLAGISAYLFTTFFL

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Crispr_ID: NZ_CP046028_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046028_3

962427-962534

Orphan

Consensus_repeat	Method
GTGGGTTCGATTCCCATCAGCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046028_3

>merge|NZ_CP046028|3|962427-962534|CRISPRCasFinder
GTGGGTTCGATTCCCATCAGCCGCCCATATCGTAAAATGCGGGTGTAGTTTAATGGCAAAACCTCAGCCTTCCAAGCTGATGTTGTGGGTTCGATTCCCATCACCCGC

>NZ_CP046028|3|2|962427-962534|CRISPRCasFinder
GTGGGTTCGATTCCCATCAGCCGC	CCATATCGTAAAATGCGGGTGTAGTTTAATGGCAAAACCTCAGCCTTCCAAGCTGATGTT
GTGGGTTCGATTCCCATCACCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046028.1\|WP_165885591.1\|952939_953470_-\|HTH-type-transcriptional-regulator-Hpr	unknown	unknown	gnl\|CDD\|237501
NZ_CP046028.1\|WP_165885595.1\|955298_956513_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|377581
NZ_CP046028.1\|WP_165885600.1\|965829_966534_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|119397
NZ_CP046028.1\|WP_105986546.1\|956769_957306_-\|signal-transduction-protein-TRAP	unknown	unknown	gnl\|CDD\|225209
NZ_CP046028.1\|WP_165885602.1\|966953_967196_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046028.1\|WP_165885599.1\|963027_964059_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NZ_CP046028.1\|WP_165885596.1\|957502_958546_+\|uroporphyrinogen-decarboxylase	unknown	unknown	gnl\|CDD\|234644
NZ_CP046028.1\|WP_165885593.1\|954010_954436_-\|HIT-family-protein	unknown	unknown	gnl\|CDD\|223611
NZ_CP046028.1\|WP_165885592.1\|953569_953926_-\|YtxH-domain-containing-protein	unknown	unknown	gnl\|CDD\|227313
NZ_CP046028.1\|WP_060551362.1\|964252_964969_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|367091
NZ_CP046028.1\|WP_165885598.1\|961227_961782_+\|serine-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|226075
NZ_CP046028.1\|WP_145400705.1\|958567_959500_+\|ferrochelatase	unknown	unknown	gnl\|CDD\|183526
NZ_CP046028.1\|WP_060551361.1\|965073_965265_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046028.1\|WP_165885604.1\|967708_968596_+\|DUF3102-domain-containing-protein	unknown	unknown	gnl\|CDD\|371455
NZ_CP046028.1\|WP_165885597.1\|959505_960903_+\|protoporphyrinogen-oxidase	unknown	unknown	gnl\|CDD\|237009
NZ_CP046028.1\|WP_060551356.1\|969196_969511_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046028.1\|WP_165885601.1\|966697_966940_+\|DUF739-family-protein	unknown	unknown	gnl\|CDD\|283090
NZ_CP046028.1\|WP_165885594.1\|954564_955302_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP046028.1\|WP_165885603.1\|967152_967653_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046028.1\|WP_165885605.1\|968598_969186_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP046028.1\|WP_165885591.1\|952939_953470_-\|HTH-type-transcriptional-regulator-Hpr	gnl\|CDD\|237501	PRK13777, PRK13777, HTH-type transcriptional regulator Hpr.	1.29581e-55
NZ_CP046028.1\|WP_165885595.1\|955298_956513_+\|ABC-transporter-permease	gnl\|CDD\|377581	pfam05975, EcsB, Bacterial ABC transporter protein EcsB. This family consists of several bacterial ABC transporter proteins which are homologous to the EcsB protein of Bacillus subtilis. EcsB is thought to encode a hydrophobic protein with six membrane-spanning helices in a pattern found in other hydrophobic components of ABC transporters.	9.59994e-80
NZ_CP046028.1\|WP_165885600.1\|965829_966534_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|119397	cd06529, S24_LexA-like, Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The LexA-like proteins contain two-domains: an N-terminal DNA binding domain and a C-terminal domain (CTD) that provides LexA dimerization as well as cleavage activity. They undergo autolysis, cleaving at an Ala-Gly or a Cys-Gly bond, separating the DNA-binding domain from the rest of the protein. In the presence of single-stranded DNA, the LexA, UmuD and MucA proteins interact with RecA, activating self cleavage, thus either derepressing transcription in the case of LexA or activating the lesion-bypass polymerase in the case of UmuD and MucA. The LexA proteins are serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases. LexA sequence homologs are found in almost all of the bacterial genomes sequenced to date, covering a large number of phyla, suggesting both, an ancient origin and a widespread distribution of lexA and the SOS response.	2.96994e-18
NZ_CP046028.1\|WP_105986546.1\|956769_957306_-\|signal-transduction-protein-TRAP	gnl\|CDD\|225209	COG2329, COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only].	0.00193126
NZ_CP046028.1\|WP_165885599.1\|963027_964059_-\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.94971e-32
NZ_CP046028.1\|WP_165885596.1\|957502_958546_+\|uroporphyrinogen-decarboxylase	gnl\|CDD\|234644	PRK00115, hemE, uroporphyrinogen decarboxylase; Validated.	0
NZ_CP046028.1\|WP_165885593.1\|954010_954436_-\|HIT-family-protein	gnl\|CDD\|223611	COG0537, Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only].	6.67135e-52
NZ_CP046028.1\|WP_165885592.1\|953569_953926_-\|YtxH-domain-containing-protein	gnl\|CDD\|227313	COG4980, GvpP, Gas vesicle protein [General function prediction only].	4.04871e-14
NZ_CP046028.1\|WP_060551362.1\|964252_964969_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	2.46959e-06
NZ_CP046028.1\|WP_165885598.1\|961227_961782_+\|serine-hydrolase-family-protein	gnl\|CDD\|226075	COG3545, COG3545, Predicted esterase of the alpha/beta hydrolase fold [General function prediction only].	2.69275e-37
NZ_CP046028.1\|WP_145400705.1\|958567_959500_+\|ferrochelatase	gnl\|CDD\|183526	PRK12435, PRK12435, ferrochelatase; Provisional.	0
NZ_CP046028.1\|WP_165885604.1\|967708_968596_+\|DUF3102-domain-containing-protein	gnl\|CDD\|371455	pfam11300, DUF3102, Protein of unknown function (DUF3102). This family of proteins has no known function.	6.82121e-10
NZ_CP046028.1\|WP_165885597.1\|959505_960903_+\|protoporphyrinogen-oxidase	gnl\|CDD\|237009	PRK11883, PRK11883, protoporphyrinogen oxidase; Reviewed.	0
NZ_CP046028.1\|WP_165885601.1\|966697_966940_+\|DUF739-family-protein	gnl\|CDD\|283090	pfam05339, DUF739, Protein of unknown function (DUF739). This family contains several bacteriophage proteins. Some of the proteins in this family have been labeled putative cro repressor proteins.	4.94252e-08
NZ_CP046028.1\|WP_165885594.1\|954564_955302_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	4.1397e-86

>NZ_CP046028.1|WP_165885598.1|961227_961782_+|serine-hydrolase-family-protein
MTNVYIVYGYHANENKHWFKWLKNALELEGHDVKIIDLPNPDAPDVEEWLTALKTQATAIDGDTLFVAHSLGVITTLKFINDLNVSHIGGIAMVSGFKDYLQHLPELNPFMDQNIDFENLKQKLNHRFCIASKNDETVPYSYTEELSHSLDAKLYTIEQGGHFCEEDGYETFSFLKQKIILKLD
>NZ_CP046028.1|WP_165885597.1|959505_960903_+|protoporphyrinogen-oxidase
MTKIAIVGAGITGLSSAYFIKKHYPHIDVTVYEATDQPGGKIKTVQRDGYTIELGPESYLGRKTIMTELAKDIGIKDEEIITNKTGQSFIFARNKLYPIPGGAILGVPTDIKPFMSTKLISMKGKLRALKDLKRKPIEMKEDLSVGSFFRYRLGDEILENLIEPLLSGIYGTDIDQLSLMSTFPNFKTLEDTHGSIIKGMQKVRLDREKKHSHNTEGPQGQFKQFRNGLFSFIEQLEKWLKQNNVHFKYQTPVTDLISEQKGYNVETAQEAPTFYDGVIVATPHQVFHKWFETDPGFDYFSRLEASSVATIVFAFDEKNIKNTSNGTGFVIARTSDTSITACTWTTKKWPHTTPKGKVLIRAYVGKPGDDIVETNSDEELVEIAKKDLSQMMTFYGEPDFTIVNKMPHASPQYHVGHIHEIKKIQEHIYREYPHLQITGAPFEAVGLPDCIRQAQDAVQRLIPRI
>NZ_CP046028.1|WP_145400705.1|958567_959500_+|ferrochelatase
MKKEVGLLVMAYGTPYQKSDIEPYYTDIRHGRKPSEEELNDLISRYEAIGGLSPLAKITERQAEAIRDALNERYEDIEFKLYIGLKHIHPFIEDAVEKMNNDGITEAVTVVLAPHYSNFSVGSYNRRAEEKANEYGIRLFHVKHYYQQPKFQEYWTMRVDEILANIPQEEHAKTVLVVSAHSLPEKMIKESNDPYPMELENTAKAIQQQSVIQNVAIGWQSEGNTGTPWLGPDVQDLTKALYKENKYEHFIYTPVGFVAEHLEVLYDNDYECKVVCDEIGATYHRPPMPDIHSLFIGAIVDEISNIYEKV
>NZ_CP046028.1|WP_165885596.1|957502_958546_+|uroporphyrinogen-decarboxylase
MNTPFNDTILRAIKGDTITHTPVWFMRQAGRSQPEYRKLKEKYSLFDITHQPELCAYVTALPVEQYQTDAAVLYKDIMTPLKAIGVDVDIKSGIGPVISNPIKSLSDVEKLGQIDPKRDVPFVLETIKLLTTEKLNVPLIGFTGAPFTLASYMIEGGPSKNYNKTKALMYSDETTWFKLMDTLAEMSITYVGAQVEAGAQLIQVFDSWVGALNQADYDYYIKPCMEKLINGIKAFQVPVIMFGVGASHLITSWNALPIDVLGLDWRTSILEAHHQGVSKTIQGNLDPSILLAPWPVIEERLKPILDQGLTHGKHIFNLGHGVFPEVQPETLQRVSKFVHDYTGAKLK
>NZ_CP046028.1|WP_105986546.1|956769_957306_-|signal-transduction-protein-TRAP
MKLYITYGTYGYIHQIQLNNKDRNLMIFSSEDRSVLIEETDKESVFQQPKSFRSLTRVGDISEEDFQAVISIPTSEDHKYQLEKKLDSYYPNLSEYEGYKSFRLLKPLKDNVYKVMFGFESRTAFEDFKKSSVFRENFSKEAVRALAGVTSTHSSYLERYFYPITEEEIANQQQNDEQ
>NZ_CP046028.1|WP_165885595.1|955298_956513_+|ABC-transporter-permease
MNNAKQLYVKRRQKDQKEKQYYNKFIFNGHFSVFLVILLGAFILGYGQWLRTIPTGINYSLIISIVLGLSSIFPLKTLLQKADELFLLPFEKQMRQYIQQSVYTSYFKRLPLQIVLLIIFYPLLNALHPNELFSFIVLVLLAFVLPFIGLQLRWQWFLFGLENASINLLLFIFYVSSYYVWLDGQSYMAMGSLVFIIILIYMFKSFNDKKHFPWELMLNQAKQHQSNYYKFVNMFTDVKGIEAPASRRKYLDVFLKKPKEFNQKGMYLYLFKRNFLRGKDAFHLTIRLFIIVAALMIWLHQPIISIIIAVLGMYIIILQMSQFYTQEAYGLWPQVWPASELLVIKGYEQFLYRTVIIVGILFSLIYIIMNPTELYLVMFIFAVGIATVKSTIRKLKYQESLLKD
>NZ_CP046028.1|WP_165885594.1|954564_955302_+|ABC-transporter-ATP-binding-protein
MTVQVTDLTGGYGQTPVIKNISFTLQPGEIVGLIGLNGAGKSTTIKHLLGLLTPMEGEMSISDINIKENIEAYRKRLSYIPESPVIYDTLTLKEHIEMTAMAYGIDAETAMKRAKPLLKNFRLESQLDVFPSHFSKGMKQKVMIICAFIVDPELYIIDEPFLGLDPLGIQSMLDLMESKKKEGRTVLMSTHILATAERYCDRFIILDQGEIVAMGDLEELRAQTKMPHQTLDEIYIKVTERGITT
>NZ_CP046028.1|WP_165885593.1|954010_954436_-|HIT-family-protein
MSETIFSKIIAGEIPSYKIYENEYVYAFLDISQLSKGHTLLIPKKASPNIYETDAETMQHIGEALPIVANAIKEAFNPDGLNIVQNNGEYASQSVFHIHFHLIPRYKEGMDGFDYQGETHEDAFTDEEKAAIAKQIADQIK
>NZ_CP046028.1|WP_165885592.1|953569_953926_-|YtxH-domain-containing-protein
MRALQISLGLAAGVATGLGVALTQRSKSTRIESTTVERPKSELELEVDNIKRSVSDILGYVNDIKTESQSVAGTIGDEIKTMISEFQSDINPNIERLQSHIENLQNRGEEITNFPSKK
>NZ_CP046028.1|WP_165885591.1|952939_953470_-|HTH-type-transcriptional-regulator-Hpr
MTAKQKQIESILFTHKAAMLSKVIWKNAERDWQNWLRKSGITMNEHLILMTIYAFDRVTISDISRYGVMHVSTAYNFAKRLEQQGLLTLEKDTHDKRNTFIHLTDKGTVLIENIFEQYNIDNNSVYQASEQFSSEMFHKPNFSDAHYLVAKIHGKDFIDDVNACHDHLRKHLLDAE
>NZ_CP046028.1|WP_165885599.1|963027_964059_-|site-specific-integrase
MNVTKRGNKWQYDFRLNGKRHRKSGFKTKKEATQAMNEAYNILNNGTNLTSDMPFVDFFENWIEIHKAPYLTDKSLQTYYNAKNIFEKKFGNMPLDKITRMNYQELINDYAETHTSESVRKLNYCLRSALSDAFYEGMIQKDPTYKVIVQGKKEAQAEEDKFMQLSYFYKLKEFSKEKDQLSYLFIYLCIVTGARFSEVQKLKYQDFNLSDETVHIRGTKTKNADRIIKITKEDIKHVRKVLNNFPNNIQGNIFTTGANLITHNAVTKVLQRFCLDNKLGNYTLHSLRHTHCSMLIHNGISIYYISKRLGHADITTTLSIYSHLLEETRSVEENKTLEALRSM
>NZ_CP046028.1|WP_060551362.1|964252_964969_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MSKFNFNQRIHKLKTSGNFKFKNIDYQLHYLLRKFESEKKHKGYFPKFKQGDIVFVDFGLNINHEFSNSHFAIILNHNDSNQEDIINVVPLSSKYNSKYLKINIDMKLKYITNAIDTLNDKKKEYETLLNELNEFNPHVMSDEEIQLKFTEFIKWENSSSQKIDKIDKDVSRTKDAITKLKKLKNTTYACVNSFQPISKFRIKNIYPKEISNVSVDAITLLTIINQINSDLLSLPRIE
>NZ_CP046028.1|WP_060551361.1|965073_965265_-|hypothetical-protein
MDKKEIVNETGWSLVEILKRINSLPYVTETITEESLKTMSKEEFNNLLHGDIKGAIQSEKQQI
>NZ_CP046028.1|WP_165885600.1|965829_966534_-|helix-turn-helix-domain-containing-protein
MNSFRDRLKQIMDERNISQSELSRRTKIGRNSISDYLNGKYEAKQDKVYELAKVLNVNEAWLMGFNIDKKREIDNDITSIYNKLTPPRQQNVLNYAHGQLEEQNAKNDNVIQMVTLSRIHASAAGVVGEELFDDIYEEEVEFEADKVPKGADYCVLVNGDSMEPMIRDGSCAFIKKTDTVADGTIALVIVDGAGYIKRVDIYDNVIRLVSLNPKYEDIIVQSHHDMKVCGKVVL
>NZ_CP046028.1|WP_165885601.1|966697_966940_+|DUF739-family-protein
MSYEFDYSLLYERMAEYRYSQSSLANAIPISRTSINHKLQGKNLFTQWEIKRICEILEIPPTKVGKYFFEQSVRKTVQTT
>NZ_CP046028.1|WP_165885602.1|966953_967196_+|hypothetical-protein
MQENQEYMNDAEWRIYGLISNYEKAMKAAKEENTQRTFEMHDKILKELKKEALTYREAYAVLQLVHLTLKHESEFVNLHQ
>NZ_CP046028.1|WP_165885603.1|967152_967653_-|hypothetical-protein
MDIKFLQSLDFLIQKANKERKTKNWNIVFKLNNELFTANFIKDTTSENAVFSSIESDDDKEKIALLSINSYRKLRTGNDFEGLETPLKKIIRYLENKDSFDVYRLLKFYIEKFDVDSAQLDNFAFNVKNLKTGEYFSFIEIDESSRVQFVTLATDEDLQTLIHASK
>NZ_CP046028.1|WP_165885604.1|967708_968596_+|DUF3102-domain-containing-protein
MNKLQLSNNLTTIETEIKSYQNLAGQSVFEIGRRLKHVKENDLAHGEWSNWLKSVNLNRTQATKFIKVSEEFSDDSTWNQIGLSAMYMIATLPEEERTIEHKTSNGEFKKPIDMTNRELEDLKRQIKQRDEQNAQLQSQVEQAQRSESIARKQLEEVENREPEIKREVKEVIPAHVKAQLSDRQQMIDAKDKEIQQLQERLSKAEEQKQIFEKQDYLEEDEQIASLNFQVESTVLEIKDNINRFLNENASTAFREAAIARASEKTKNQIYDGVEELEAFCRTMRRSLNSNVIVGG
>NZ_CP046028.1|WP_165885605.1|968598_969186_+|hypothetical-protein
MLLDIFKSNEEKAQQLSKETGLAPQQINQIVNATVTTMLGEIKGIFEQQQENHESTQKALRATYKQNTQLSNKLDETNERIKNVEGEFFEGKEEKALKHTIEKKAKQIIDKKGSQMSIDLNIEENYLDIYQQVDAKEKRDAQYKRDLGKCKNKVLKSTLKYMGYKGNASYRDIKKRDLDRMLKYILSLRPSDIEI
>NZ_CP046028.1|WP_060551356.1|969196_969511_+|hypothetical-protein
MTNEDAIKVIKLQREHSRLLGQIEAYNSALSKIEESRELFNGLFDETRDKGVFAGIAVIENKVVIGCQQAIKEIKKVSKEIDALAGIDTDDTVTNLEEWKMLNQ

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP046028_2	2.5\|159599\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159599-159628	30	NZ_KX520649	Staphylococcus epidermidis strain 14-01514 plasmid p14-01514, complete sequence	4222-4251	0	1.0
NZ_CP046028_2	2.5\|159599\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159599-159628	30	NZ_KX149096	Staphylococcus aureus strain WG260 plasmid pWBG4, complete sequence	24335-24364	0	1.0
NZ_CP046028_2	2.5\|159599\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159599-159628	30	NZ_KM521837	Staphylococcus epidermidis strain 12-02300 plasmid p12-02300, complete sequence	3281-3310	0	1.0
NZ_CP046028_2	2.5\|159599\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159599-159628	30	NZ_AP019752	Staphylococcus aureus strain JRA307 plasmid pJRA307-1, complete sequence	43695-43724	0	1.0
NZ_CP046028_2	2.5\|159599\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159599-159628	30	NZ_MH587576	Staphylococcus aureus strain WG512 plasmid pWBG14, complete sequence	5226-5255	0	1.0
NZ_CP046028_2	2.5\|159599\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159599-159628	30	NZ_KU521355	Staphylococcus aureus subsp. aureus strain M12/0145 plasmid pSAM12-0145 clone ST22, complete sequence	14891-14920	2	0.933
NZ_CP046028_2	2.5\|159599\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159599-159628	30	NZ_CP028164	Staphylococcus aureus strain CFSAN064038 plasmid pGMI17-006, complete sequence	16502-16531	2	0.933
NZ_CP046028_2	2.5\|159599\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159599-159628	30	NC_021076	Staphylococcus aureus strain 004-737X plasmid pSA737, complete sequence	12587-12616	2	0.933
NZ_CP046028_2	2.5\|159599\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159599-159628	30	NZ_KY436023	Staphylococcus aureus strain NRL 11/608 plasmid pETB608, complete sequence	10746-10775	2	0.933
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	NC_007055	Staphylococcus phage 37, complete genome	8394-8423	3	0.9
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	AY954958	Bacteriophage 37, complete genome	8394-8423	3	0.9
NZ_CP046028_2	2.5\|159599\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159599-159628	30	NZ_KX149097	Staphylococcus aureus strain WBG7410 plasmid pWBG707, complete sequence	30718-30747	3	0.9
NZ_CP046028_2	2.5\|159599\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159599-159628	30	NZ_CP029628	Staphylococcus aureus strain MOK042 plasmid unnamed, complete sequence	19409-19438	3	0.9
NZ_CP046028_2	2.5\|159599\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159599-159628	30	NZ_MH587577	Staphylococcus aureus strain WBG10513 plasmid pWBG707, complete sequence	5297-5326	3	0.9
NZ_CP046028_1	1.1\|87865\|30\|NZ_CP046028\|CRT	87865-87894	30	NZ_CP023283	Nostoc sp. CENA543 plasmid pCENA543d, complete sequence	23225-23254	6	0.8
NZ_CP046028_2	2.5\|159599\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159599-159628	30	MN693474	Marine virus AFVG_25M212, complete genome	1432-1461	6	0.8
NZ_CP046028_2	2.5\|159599\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159599-159628	30	NZ_CP013054	Sinorhizobium americanum CCGM7 plasmid C, complete sequence	1560317-1560346	6	0.8
NZ_CP046028_2	2.5\|159599\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159599-159628	30	NZ_CP027301	Serratia marcescens strain SGAir0764 plasmid unnamed_1	42295-42324	6	0.8
NZ_CP046028_3	3.1\|962451\|60\|NZ_CP046028\|CRISPRCasFinder	962451-962510	60	NC_020451	Vibrio coralliilyticus strain ATCC BAA-450 plasmid, complete sequence	1965-2024	6	0.9
NZ_CP046028_1	1.1\|87865\|30\|NZ_CP046028\|CRT	87865-87894	30	MT104122	Sporosarcina phage Lietuvens, complete genome	6785-6814	7	0.767
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	NZ_CP023674	Escherichia coli strain SMN013SH2 plasmid pO177A2, complete sequence	12494-12523	7	0.767
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	KR131710	Fusobacterium phage Funu1, complete genome	19740-19769	7	0.767
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	HM144387	Bacillus phage W.Ph., complete genome	12373-12402	7	0.767
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	KM236245	Bacillus phage Mater, complete genome	128835-128864	7	0.767
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	HQ634191	Cyanophage Syn10 genomic sequence	14471-14500	7	0.767
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	DQ149023	Synechococcus cyanophage syn9, complete genome	135553-135582	7	0.767
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	NC_008296	Synechococcus phage syn9, complete genome	135553-135582	7	0.767
NZ_CP046028_1	1.1\|87865\|30\|NZ_CP046028\|CRT	87865-87894	30	NC_028247	Citrobacter phage Michonne, complete genome	1872-1901	8	0.733
NZ_CP046028_1	1.1\|87865\|30\|NZ_CP046028\|CRT	87865-87894	30	MH920362	Citrobacter phage Maleficent, complete genome	1908-1937	8	0.733
NZ_CP046028_1	1.1\|87865\|30\|NZ_CP046028\|CRT	87865-87894	30	NC_041977	Citrobacter phage Mordin, complete genome	486-515	8	0.733
NZ_CP046028_2	2.1\|159335\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159335-159364	30	NZ_CP054025	Rhizobium sp. JKLM12A2 plasmid pPR12A204, complete sequence	136823-136852	8	0.733
NZ_CP046028_2	2.2\|159401\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159401-159430	30	MN204493	Streptomyces phage Zuko, complete genome	40815-40844	8	0.733
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	NZ_CP038392	Escherichia coli O157:H7 strain DEC5B plasmid pDEC5B-4, complete sequence	42117-42146	8	0.733
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	NZ_CP041427	Escherichia coli strain STEC388 plasmid pSTEC388_2, complete sequence	15370-15399	8	0.733
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	NZ_CP013929	Alteromonas mediterranea strain UM8 plasmid pAMEDUM8_300, complete sequence	54430-54459	8	0.733
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	CP013931	Alteromonas mediterranea strain U10 plasmid pAMED10_300, complete sequence	54436-54465	8	0.733
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	NC_019394	Alteromonas mediterranea DE1 plasmid pAMDE1, complete sequence	54808-54837	8	0.733
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	NZ_CP018322	Alteromonas macleodii strain Te101 plasmid pTE101a, complete sequence	55005-55034	8	0.733
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	NC_027341	Lactococcus phage WRP3, complete genome	33373-33402	8	0.733
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	KF926093	Lactococcus phage phiL47, complete genome	34467-34496	8	0.733
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	LR745207	uncultured phage genome assembly, chromosome: 1	223374-223403	8	0.733
NZ_CP046028_2	2.4\|159533\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159533-159562	30	MN693864	Marine virus AFVG_250M734, complete genome	4904-4933	8	0.733
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	NZ_CP053953	Bacillus cereus strain FDAARGOS_798 plasmid unnamed2, complete sequence	5973-6002	9	0.7
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	NZ_CP053953	Bacillus cereus strain FDAARGOS_798 plasmid unnamed2, complete sequence	5997-6026	9	0.7
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	NZ_CP053953	Bacillus cereus strain FDAARGOS_798 plasmid unnamed2, complete sequence	6021-6050	9	0.7
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	NZ_CP030780	Escherichia albertii strain 05-3106 plasmid unnamed2, complete sequence	55391-55420	9	0.7
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	NZ_CP053950	Bacillus cereus strain FDAARGOS_799 plasmid unnamed2, complete sequence	228343-228372	9	0.7
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	NZ_CP053950	Bacillus cereus strain FDAARGOS_799 plasmid unnamed2, complete sequence	228367-228396	9	0.7
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	NZ_CP053950	Bacillus cereus strain FDAARGOS_799 plasmid unnamed2, complete sequence	228391-228420	9	0.7
NZ_CP046028_2	2.3\|159467\|30\|NZ_CP046028\|PILER-CR,CRISPRCasFinder,CRT	159467-159496	30	MG744354	Lactobacillus phage Satyr, complete genome	46369-46398	9	0.7
NZ_CP046028_3	3.1\|962451\|60\|NZ_CP046028\|CRISPRCasFinder	962451-962510	60	NC_004604	Bacillus megaterium QM B1551 plasmid pBM400, complete sequence	46415-46474	10	0.833
NZ_CP046028_3	3.1\|962451\|60\|NZ_CP046028\|CRISPRCasFinder	962451-962510	60	CP031730	Stenotrophomonas rhizophila strain GA1 plasmid unnamed1, complete sequence	5218-5277	11	0.817
NZ_CP046028_3	3.1\|962451\|60\|NZ_CP046028\|CRISPRCasFinder	962451-962510	60	NZ_CP033045	Bacillus foraminis strain Bac44 plasmid unnamed, complete sequence	483786-483845	12	0.8

1. spacer 2.5|159599|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_KX520649 (Staphylococcus epidermidis strain 14-01514 plasmid p14-01514, complete sequence) position: , mismatch: 0, identity: 1.0

tctctcctcgaaaaattggaggagaaaggt	CRISPR spacer
tctctcctcgaaaaattggaggagaaaggt	Protospacer
******************************

2. spacer 2.5|159599|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_KX149096 (Staphylococcus aureus strain WG260 plasmid pWBG4, complete sequence) position: , mismatch: 0, identity: 1.0

tctctcctcgaaaaattggaggagaaaggt	CRISPR spacer
tctctcctcgaaaaattggaggagaaaggt	Protospacer
******************************

3. spacer 2.5|159599|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_KM521837 (Staphylococcus epidermidis strain 12-02300 plasmid p12-02300, complete sequence) position: , mismatch: 0, identity: 1.0

tctctcctcgaaaaattggaggagaaaggt	CRISPR spacer
tctctcctcgaaaaattggaggagaaaggt	Protospacer
******************************

4. spacer 2.5|159599|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP019752 (Staphylococcus aureus strain JRA307 plasmid pJRA307-1, complete sequence) position: , mismatch: 0, identity: 1.0

tctctcctcgaaaaattggaggagaaaggt	CRISPR spacer
tctctcctcgaaaaattggaggagaaaggt	Protospacer
******************************

5. spacer 2.5|159599|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_MH587576 (Staphylococcus aureus strain WG512 plasmid pWBG14, complete sequence) position: , mismatch: 0, identity: 1.0

tctctcctcgaaaaattggaggagaaaggt	CRISPR spacer
tctctcctcgaaaaattggaggagaaaggt	Protospacer
******************************

6. spacer 2.5|159599|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_KU521355 (Staphylococcus aureus subsp. aureus strain M12/0145 plasmid pSAM12-0145 clone ST22, complete sequence) position: , mismatch: 2, identity: 0.933

tctctcctcgaaaaattggaggagaaaggt	CRISPR spacer
tctctcctcaaaaaattggaggagaaaggc	Protospacer
*********.*******************.

7. spacer 2.5|159599|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP028164 (Staphylococcus aureus strain CFSAN064038 plasmid pGMI17-006, complete sequence) position: , mismatch: 2, identity: 0.933

tctctcctcgaaaaattggaggagaaaggt	CRISPR spacer
tctctcctcaaaaaattggaggagaaaggc	Protospacer
*********.*******************.

8. spacer 2.5|159599|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NC_021076 (Staphylococcus aureus strain 004-737X plasmid pSA737, complete sequence) position: , mismatch: 2, identity: 0.933

tctctcctcgaaaaattggaggagaaaggt	CRISPR spacer
tctctcctcaaaaaattggaggagaaaggc	Protospacer
*********.*******************.

9. spacer 2.5|159599|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_KY436023 (Staphylococcus aureus strain NRL 11/608 plasmid pETB608, complete sequence) position: , mismatch: 2, identity: 0.933

tctctcctcgaaaaattggaggagaaaggt	CRISPR spacer
tctctcctcaaaaaaatggaggagaaaggt	Protospacer
*********.***** **************

10. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NC_007055 (Staphylococcus phage 37, complete genome) position: , mismatch: 3, identity: 0.9

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
ttagtgaaggaagaggacaaagaagaagcc	Protospacer
********.*****************.**

11. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to AY954958 (Bacteriophage 37, complete genome) position: , mismatch: 3, identity: 0.9

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
ttagtgaaggaagaggacaaagaagaagcc	Protospacer
********.*****************.**

12. spacer 2.5|159599|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_KX149097 (Staphylococcus aureus strain WBG7410 plasmid pWBG707, complete sequence) position: , mismatch: 3, identity: 0.9

tctctcctcgaaaaattggaggagaaaggt	CRISPR spacer
tctctcctcaaaaaaatggaggagaaaggc	Protospacer
*********.***** *************.

13. spacer 2.5|159599|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029628 (Staphylococcus aureus strain MOK042 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.9

tctctcctcgaaaaattggaggagaaaggt	CRISPR spacer
tctctcctcaaaaaaatggaggagaaaggc	Protospacer
*********.***** *************.

14. spacer 2.5|159599|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_MH587577 (Staphylococcus aureus strain WBG10513 plasmid pWBG707, complete sequence) position: , mismatch: 3, identity: 0.9

tctctcctcgaaaaattggaggagaaaggt	CRISPR spacer
tctctcctcaaaaaaatggaggagaaaggc	Protospacer
*********.***** *************.

15. spacer 1.1|87865|30|NZ_CP046028|CRT matches to NZ_CP023283 (Nostoc sp. CENA543 plasmid pCENA543d, complete sequence) position: , mismatch: 6, identity: 0.8

caggact-tggttctggagttgggttaggat	CRISPR spacer
-ggcattatggctctggagttgggtttggat	Protospacer
 .* *.* ***.************** ****

16. spacer 2.5|159599|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to MN693474 (Marine virus AFVG_25M212, complete genome) position: , mismatch: 6, identity: 0.8

tctctcctcgaaaaattggaggagaaaggt	CRISPR spacer
ttcctcctcgataaattgaaggagaaagag	Protospacer
*..******** ******.*********.

17. spacer 2.5|159599|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013054 (Sinorhizobium americanum CCGM7 plasmid C, complete sequence) position: , mismatch: 6, identity: 0.8

tctctcctcgaaaaattggaggagaaaggt	CRISPR spacer
tcgctcctcgaaaaattggaggcggagaga	Protospacer
** ******************* *.*..*

18. spacer 2.5|159599|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027301 (Serratia marcescens strain SGAir0764 plasmid unnamed_1) position: , mismatch: 6, identity: 0.8

tctctcctcgaaaaattggaggagaaaggt	CRISPR spacer
tatgtgctcgaaaaattggaggggaaattt	Protospacer
* * * ****************.****  *

19. spacer 3.1|962451|60|NZ_CP046028|CRISPRCasFinder matches to NC_020451 (Vibrio coralliilyticus strain ATCC BAA-450 plasmid, complete sequence) position: , mismatch: 6, identity: 0.9

-ccatatcgtaaaatgcgggtgtagtttaatggcaaaacctcagccttccaagctgatgt	CRISPR spacer
gccataac-taaaatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatga	Protospacer
 ***** * ********************.***.*************************

20. spacer 1.1|87865|30|NZ_CP046028|CRT matches to MT104122 (Sporosarcina phage Lietuvens, complete genome) position: , mismatch: 7, identity: 0.767

caggacttggttctggagttgggttaggat	CRISPR spacer
tcggacttggttcgggcgttgggttatcgt	Protospacer
. *********** ** *********  .*

21. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP023674 (Escherichia coli strain SMN013SH2 plasmid pO177A2, complete sequence) position: , mismatch: 7, identity: 0.767

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
gaacggaaagaagaggaaaaagaagaggaa	Protospacer
  *  ************ ********** .

22. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to KR131710 (Fusobacterium phage Funu1, complete genome) position: , mismatch: 7, identity: 0.767

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
aacctgaacgaataggacaaagaagaggag	Protospacer
    **** *** *************** *

23. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to HM144387 (Bacillus phage W.Ph., complete genome) position: , mismatch: 7, identity: 0.767

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
gaagtgaaagaagaggaaaaagcagaagaa	Protospacer
  *************** **** ***.* .

24. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to KM236245 (Bacillus phage Mater, complete genome) position: , mismatch: 7, identity: 0.767

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
tctgagaaggaagaggacaaagaagagaaa	Protospacer
*. * ***.******************. .

25. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to HQ634191 (Cyanophage Syn10 genomic sequence) position: , mismatch: 7, identity: 0.767

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
aaaaagaaagaagagaaaaaagaagaggag	Protospacer
  *. **********.* ********** *

26. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to DQ149023 (Synechococcus cyanophage syn9, complete genome) position: , mismatch: 7, identity: 0.767

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
aaaaagaaagaagagaaaaaagaagaggag	Protospacer
  *. **********.* ********** *

27. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NC_008296 (Synechococcus phage syn9, complete genome) position: , mismatch: 7, identity: 0.767

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
aaaaagaaagaagagaaaaaagaagaggag	Protospacer
  *. **********.* ********** *

28. spacer 1.1|87865|30|NZ_CP046028|CRT matches to NC_028247 (Citrobacter phage Michonne, complete genome) position: , mismatch: 8, identity: 0.733

caggacttggttctggagttgggttaggat	CRISPR spacer
aaccgtttggttctgtagttgggttagtag	Protospacer
 *  ..********* *********** *

29. spacer 1.1|87865|30|NZ_CP046028|CRT matches to MH920362 (Citrobacter phage Maleficent, complete genome) position: , mismatch: 8, identity: 0.733

caggacttggttctggagttgggttaggat	CRISPR spacer
aaccgtttggttctgtagttgggttagtag	Protospacer
 *  ..********* *********** *

30. spacer 1.1|87865|30|NZ_CP046028|CRT matches to NC_041977 (Citrobacter phage Mordin, complete genome) position: , mismatch: 8, identity: 0.733

caggacttggttctggagttgggttaggat	CRISPR spacer
aaccgtttggttctgtagttgggttagtag	Protospacer
 *  ..********* *********** *

31. spacer 2.1|159335|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP054025 (Rhizobium sp. JKLM12A2 plasmid pPR12A204, complete sequence) position: , mismatch: 8, identity: 0.733

tctaactgcattctccagcgtccttgatga	CRISPR spacer
cgcgtgtgctttctccggcgtccttgatga	Protospacer
. ..  *** ******.*************

32. spacer 2.2|159401|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to MN204493 (Streptomyces phage Zuko, complete genome) position: , mismatch: 8, identity: 0.733

tggccagaacgagcaaaacaacaaggctac	CRISPR spacer
caccaccaacgagcagtacaacaaggctac	Protospacer
.. *   ********. *************

33. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP038392 (Escherichia coli O157:H7 strain DEC5B plasmid pDEC5B-4, complete sequence) position: , mismatch: 8, identity: 0.733

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
gaatggaaagaagaggaaaaagaagaagaa	Protospacer
  *  ************ ********.* .

34. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP041427 (Escherichia coli strain STEC388 plasmid pSTEC388_2, complete sequence) position: , mismatch: 8, identity: 0.733

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
gaacggaaagaagaggaaaaagaagaagaa	Protospacer
  *  ************ ********.* .

35. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013929 (Alteromonas mediterranea strain UM8 plasmid pAMEDUM8_300, complete sequence) position: , mismatch: 8, identity: 0.733

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
gaggccgaagaagaggacgaagaagaggag	Protospacer
  .*. .***********.********* *

36. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to CP013931 (Alteromonas mediterranea strain U10 plasmid pAMED10_300, complete sequence) position: , mismatch: 8, identity: 0.733

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
gaggccgaagaagaggacgaagaagaggag	Protospacer
  .*. .***********.********* *

37. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NC_019394 (Alteromonas mediterranea DE1 plasmid pAMDE1, complete sequence) position: , mismatch: 8, identity: 0.733

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
gaggccgaagaagaggacgaagaagaggag	Protospacer
  .*. .***********.********* *

38. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP018322 (Alteromonas macleodii strain Te101 plasmid pTE101a, complete sequence) position: , mismatch: 8, identity: 0.733

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
gaggccgaagaagaggacgaagaagaggag	Protospacer
  .*. .***********.********* *

39. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NC_027341 (Lactococcus phage WRP3, complete genome) position: , mismatch: 8, identity: 0.733

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
attgtgaaagaagaagtcaaagaagaaaaa	Protospacer
 * ***********.* *********.. .

40. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to KF926093 (Lactococcus phage phiL47, complete genome) position: , mismatch: 8, identity: 0.733

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
attgtgaaagaagaagtcaaagaagaaaaa	Protospacer
 * ***********.* *********.. .

41. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to LR745207 (uncultured phage genome assembly, chromosome: 1) position: , mismatch: 8, identity: 0.733

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
aaggtcaaagaagaagacaaagaagaagta	Protospacer
  .** ********.***********.*..

42. spacer 2.4|159533|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to MN693864 (Marine virus AFVG_250M734, complete genome) position: , mismatch: 8, identity: 0.733

cgttcccactcagcaattgccccgacaagc	CRISPR spacer
aaagcgctatcagcaattgcccccacaagc	Protospacer
 .  * *  ************** ******

43. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP053953 (Bacillus cereus strain FDAARGOS_798 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.7

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
gaggaagaagaagaggacgaagaagaggaa	Protospacer
  .* ..***********.********* .

44. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP053953 (Bacillus cereus strain FDAARGOS_798 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.7

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
gaggaagaagaagaggacgaagaagaggaa	Protospacer
  .* ..***********.********* .

45. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP053953 (Bacillus cereus strain FDAARGOS_798 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.7

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
gaggaagaagaagaggacgaagaagaggac	Protospacer
  .* ..***********.*********

46. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP030780 (Escherichia albertii strain 05-3106 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.7

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
gaatggaaagaagaggaaaaagaagaacaa	Protospacer
  *  ************ ********.  .

47. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP053950 (Bacillus cereus strain FDAARGOS_799 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.7

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
gaggaagaagaagaggacgaagaagaggaa	Protospacer
  .* ..***********.********* .

48. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP053950 (Bacillus cereus strain FDAARGOS_799 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.7

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
gaggaagaagaagaggacgaagaagaggaa	Protospacer
  .* ..***********.********* .

49. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP053950 (Bacillus cereus strain FDAARGOS_799 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.7

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
gaggaagaagaagaggacgaagaagaggac	Protospacer
  .* ..***********.*********

50. spacer 2.3|159467|30|NZ_CP046028|PILER-CR,CRISPRCasFinder,CRT matches to MG744354 (Lactobacillus phage Satyr, complete genome) position: , mismatch: 9, identity: 0.7

ttagtgaaagaagaggacaaagaagaggcg	CRISPR spacer
aaagtgaaagacgaagacaaagaagcccta	Protospacer
  ********* **.**********   ..

51. spacer 3.1|962451|60|NZ_CP046028|CRISPRCasFinder matches to NC_004604 (Bacillus megaterium QM B1551 plasmid pBM400, complete sequence) position: , mismatch: 10, identity: 0.833

ccatatcgtaaaatgcgggtgtagtttaatggcaaaacctcagccttccaagctgatgtt	CRISPR spacer
ttttaagaaaacatgcgggtgtagtttaatggtaaaacctcagccttccaagctgatgtc	Protospacer
.. **  . ** ********************.**************************.

52. spacer 3.1|962451|60|NZ_CP046028|CRISPRCasFinder matches to CP031730 (Stenotrophomonas rhizophila strain GA1 plasmid unnamed1, complete sequence) position: , mismatch: 11, identity: 0.817

ccatatcgtaaaat---gcgggtgtagtttaatggcaaaacctcagccttccaagctgat	CRISPR spacer
---tttttaaaaataaagcgggtgtagtttaatggtaaaacctcagccttccaagctgat	Protospacer
   * *.  *****   ******************.************************

53. spacer 3.1|962451|60|NZ_CP046028|CRISPRCasFinder matches to NZ_CP033045 (Bacillus foraminis strain Bac44 plasmid unnamed, complete sequence) position: , mismatch: 12, identity: 0.8

ccatatcgtaaaatgcgggtgtagtttaatggcaaaacctcagccttccaagctgatgtt	CRISPR spacer
aaacttttaaccatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgat	Protospacer
  *. *.  *  ****************.***.************************* *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

963027 : 1047919

105

Staphylococcus_phage(58.44%)

capsid,portal,protease,head,tRNA,transposase,terminase,tail,integrase

attL 956715:956736|attR 1034172:1034193

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
956715:956736	attL	NA	NA	NA	NA
WP_165885599.1\|963027_964059_-\|integrase	site-specific integrase	U3PJ31	Staphylococcus_phage	4.2e-137	70.0
WP_060551362.1\|964252_964969_-	type II toxin-antitoxin system PemK/MazF family toxin	H9A0K1	Staphylococcus_phage	3.8e-76	64.4
WP_060551361.1\|965073_965265_-	hypothetical protein	NA	NA	NA	NA
WP_165885600.1\|965829_966534_-	helix-turn-helix domain-containing protein	A0A2I6PDG6	Staphylococcus_phage	3.5e-82	68.5
WP_165885601.1\|966697_966940_+	DUF739 family protein	Q9G038	Staphylococcus_virus	1.1e-35	91.2
WP_165885602.1\|966953_967196_+	hypothetical protein	NA	NA	NA	NA
WP_165885603.1\|967152_967653_-	hypothetical protein	NA	NA	NA	NA
WP_165885604.1\|967708_968596_+	DUF3102 domain-containing protein	A0A2H4JAH5	uncultured_Caudovirales_phage	1.6e-36	64.2
WP_165885605.1\|968598_969186_+	hypothetical protein	NA	NA	NA	NA
WP_060551356.1\|969196_969511_+	hypothetical protein	S4V9P0	Staphylococcus_phage	4.0e-14	38.6
WP_060551355.1\|969552_969786_+	hypothetical protein	A0A2H4JBS5	uncultured_Caudovirales_phage	2.1e-12	50.0
WP_060551354.1\|969771_970107_-	hypothetical protein	M9NS98	Staphylococcus_phage	2.3e-15	40.7
WP_060551353.1\|970155_970398_+	hypothetical protein	A0A2H4J7P2	uncultured_Caudovirales_phage	1.6e-23	77.9
WP_060552492.1\|970522_970720_+	hypothetical protein	A0A1J0MFJ7	Staphylococcus_phage	1.2e-05	45.3
WP_165885606.1\|970732_971059_+	DUF771 domain-containing protein	Q4ZC28	Staphylococcus_virus	5.3e-09	34.3
WP_165885607.1\|971308_971575_+	DUF1108 family protein	A0A1J0MFD3	Staphylococcus_phage	8.9e-07	33.3
WP_165885608.1\|971574_972111_+	hypothetical protein	A0A0H3U480	Staphylococcus_phage	1.4e-59	67.8
WP_165885609.1\|972111_972753_+	single-stranded DNA-binding protein	A0A1J0MF78	Staphylococcus_phage	1.0e-72	63.0
WP_165885610.1\|972752_973172_+	single-stranded DNA-binding protein	A0A1J0MFD7	Staphylococcus_phage	1.0e-49	86.5
WP_165885611.1\|973183_973858_+	hypothetical protein	A0A1J0MFX6	Staphylococcus_phage	1.6e-113	87.8
WP_165885304.1\|973854_974058_+	hypothetical protein	NA	NA	NA	NA
WP_165885612.1\|974096_974885_+	DnaD domain protein	A0A223LFI6	Staphylococcus_phage	1.4e-76	79.6
WP_165885613.1\|974881_975223_+	hypothetical protein	Q4ZC18	Staphylococcus_virus	1.1e-41	72.6
WP_165885614.1\|975215_976454_+	AAA family ATPase	Q4ZC17	Staphylococcus_virus	8.2e-228	97.8
WP_165885615.1\|976655_977078_+	RusA family crossover junction endodeoxyribonuclease	Q4ZC15	Staphylococcus_virus	5.7e-72	92.9
WP_165885616.1\|977079_977499_+	hypothetical protein	Q4ZC14	Staphylococcus_virus	5.9e-21	41.6
WP_165885617.1\|977495_977687_+	hypothetical protein	Q4ZC13	Staphylococcus_virus	1.9e-19	71.9
WP_165885962.1\|977760_977985_+	DUF3310 domain-containing protein	Q4ZC12	Staphylococcus_virus	7.2e-34	93.2
WP_165885618.1\|977984_978197_+	hypothetical protein	Q4ZC11	Staphylococcus_virus	4.6e-22	71.4
WP_060550729.1\|978208_978613_+	hypothetical protein	A0A0U1ZWJ6	Staphylococcus_phage	3.5e-10	36.7
WP_165885305.1\|978609_978954_+	hypothetical protein	A0A2H4J207	uncultured_Caudovirales_phage	1.1e-25	57.4
WP_165885619.1\|979007_979169_+	hypothetical protein	Q4ZC05	Staphylococcus_virus	1.5e-20	90.6
WP_165885620.1\|979180_979699_+	dUTPase	A0A2H4JA54	uncultured_Caudovirales_phage	7.2e-77	84.8
WP_165885621.1\|979890_980100_+	hypothetical protein	NA	NA	NA	NA
WP_060551333.1\|980378_980894_+	hypothetical protein	NA	NA	NA	NA
WP_165885622.1\|980957_981176_+	hypothetical protein	A0A2H4J460	uncultured_Caudovirales_phage	2.5e-23	72.2
WP_165885623.1\|981193_981589_+	hypothetical protein	A0A2H4J610	uncultured_Caudovirales_phage	3.0e-59	85.5
WP_165885624.1\|981805_981991_+	type II toxin-antitoxin system HicA family toxin	A0A0D4DC32	Acinetobacter_phage	7.1e-19	75.4
WP_060551331.1\|982025_982421_+	antitoxin HicB	M1PG28	Streptococcus_phage	7.5e-26	44.0
WP_060552489.1\|982903_983203_+	HNH endonuclease	A0A1W6JQ75	Staphylococcus_phage	4.8e-33	70.0
WP_060551330.1\|983339_983723_+	hypothetical protein	A0A1X9H0I2	Staphylococcus_phage	4.1e-29	65.5
WP_165885625.1\|983709_985377_+\|terminase	terminase large subunit	A0A059T7Q8	Listeria_phage	1.4e-198	60.4
WP_060551328.1\|985396_986575_+\|portal	phage portal protein	A8AT96	Listeria_phage	8.6e-102	49.6
WP_060552488.1\|986537_987251_+\|protease	Clp protease ClpP	A0A2H4J8Y7	uncultured_Caudovirales_phage	1.2e-50	53.5
WP_060551327.1\|987262_988462_+\|capsid	phage major capsid protein	A0A2H4JHT8	uncultured_Caudovirales_phage	5.5e-88	47.3
WP_060551326.1\|988479_988767_+\|head,tail	phage gp6-like head-tail connector protein	A0A2H4JAA9	uncultured_Caudovirales_phage	3.4e-20	57.8
WP_060551325.1\|988750_989119_+	hypothetical protein	NA	NA	NA	NA
WP_060551324.1\|989108_989498_+	hypothetical protein	A0A2H4J7V9	uncultured_Caudovirales_phage	9.6e-34	56.8
WP_060552487.1\|989518_989914_+	hypothetical protein	A0A2H4JBV0	uncultured_Caudovirales_phage	1.5e-21	43.3
WP_060551323.1\|989926_990550_+\|tail	phage tail protein	A0A2H4JDS5	uncultured_Caudovirales_phage	1.6e-70	62.9
WP_165885963.1\|990561_990747_+	hypothetical protein	A0A0N9STM6	Staphylococcus_phage	2.4e-11	55.7
WP_060551322.1\|990814_991186_+	hypothetical protein	A0A2H4JH57	uncultured_Caudovirales_phage	1.5e-36	62.6
WP_165885626.1\|991245_991389_+	hypothetical protein	A0A2H4JAE7	uncultured_Caudovirales_phage	1.0e-09	68.2
WP_165885627.1\|991405_996211_+\|tail	phage tail tape measure protein	A0A1J0MFP9	Staphylococcus_phage	1.0e-281	59.1
WP_165885628.1\|996207_997695_+\|tail	phage tail protein	Q4ZD64	Staphylococcus_phage	1.1e-109	41.9
WP_165885629.1\|997696_1001179_+	hypothetical protein	A0A1Q1PW30	Staphylococcus_phage	1.4e-163	35.9
WP_156407408.1\|1001188_1001338_+	hypothetical protein	NA	NA	NA	NA
WP_060551318.1\|1001380_1001695_+	hypothetical protein	NA	NA	NA	NA
WP_060551317.1\|1001743_1002088_+	hypothetical protein	NA	NA	NA	NA
WP_060551316.1\|1002227_1002476_+	hypothetical protein	Q4ZD59	Staphylococcus_phage	2.0e-37	92.7
WP_165885630.1\|1002477_1003947_+	peptidoglycan DD-metalloendopeptidase family protein	A0A1J0MFY3	Staphylococcus_phage	9.4e-231	81.0
WP_060551314.1\|1004528_1005266_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_060551313.1\|1005556_1005781_+	hypothetical protein	NA	NA	NA	NA
WP_060551312.1\|1005770_1006214_+	DUF2335 domain-containing protein	NA	NA	NA	NA
WP_037574540.1\|1008840_1009026_+	hypothetical protein	NA	NA	NA	NA
WP_145400712.1\|1009888_1010743_+\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_037574536.1\|1011255_1012002_-	SDR family oxidoreductase	Q06VL0	Trichoplusia_ni_ascovirus	7.6e-19	29.8
WP_103158796.1\|1012314_1012866_+	alkaline shock response membrane anchor protein AmaP	NA	NA	NA	NA
WP_037574531.1\|1012886_1013129_+	DUF2273 domain-containing protein	NA	NA	NA	NA
WP_145400714.1\|1013176_1013671_+	Asp23/Gls24 family envelope stress response protein	NA	NA	NA	NA
WP_165885631.1\|1013920_1015330_+	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	1.2e-129	49.9
WP_165885632.1\|1015326_1016316_+	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	1.2e-75	43.8
WP_037574520.1\|1016312_1016543_-	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	8.5e-30	78.1
WP_037574517.1\|1016605_1017070_+	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	2.6e-38	51.6
WP_151365244.1\|1017080_1017842_+	prolyl oligopeptidase family serine peptidase	A0A2H4PQM6	Staphylococcus_phage	3.9e-87	61.9
WP_165885633.1\|1017877_1019458_-	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	1.3e-241	75.8
WP_165885634.1\|1019890_1021090_+	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	9.8e-178	80.6
WP_165885635.1\|1021179_1022088_+	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	1.5e-90	66.9
WP_165885636.1\|1022336_1023173_+	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	1.0e-112	69.3
WP_037574506.1\|1023304_1023679_-	CrcB family protein	NA	NA	NA	NA
WP_165885637.1\|1023675_1024041_-	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	3.1e-18	43.8
WP_165885638.1\|1024058_1024361_-	hypothetical protein	NA	NA	NA	NA
WP_165885639.1\|1024510_1025221_+	transaldolase	M1PR54	Cyanophage	1.2e-21	37.0
WP_165885640.1\|1025321_1025774_+	hypothetical protein	NA	NA	NA	NA
WP_165885641.1\|1025753_1026182_-	hypothetical protein	NA	NA	NA	NA
WP_145400721.1\|1026199_1026667_-	sigma-70 family RNA polymerase sigma factor	A0A2H4PQT5	Staphylococcus_phage	5.6e-20	44.0
WP_037574491.1\|1026862_1027087_+	hypothetical protein	NA	NA	NA	NA
WP_037574490.1\|1027249_1028116_+	autolysin	A0A1W6JQU5	Staphylococcus_phage	9.3e-37	37.9
WP_105965364.1\|1028647_1030276_+	FAD-dependent oxidoreductase	A0A2H4PQX2	Staphylococcus_phage	7.9e-13	61.7
WP_037574486.1\|1030665_1031712_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	7.9e-107	52.9
WP_037574483.1\|1031716_1032346_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.2e-57	55.7
WP_037574481.1\|1032359_1033541_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	6.5e-150	65.4
WP_037574478.1\|1033558_1034017_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	2.2e-53	68.0
WP_151364883.1\|1034279_1035326_-	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	2.4e-124	68.3
1034172:1034193	attR	NA	NA	NA	NA
WP_145400724.1\|1035853_1036186_+	hypothetical protein	NA	NA	NA	NA
WP_145401813.1\|1036417_1037716_+\|transposase	ISL3 family transposase	A0A2D1GQC1	Lysinibacillus_phage	4.2e-09	20.9
WP_037574472.1\|1037879_1038701_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_145400725.1\|1038821_1039778_+	L-lactate dehydrogenase	NA	NA	NA	NA
WP_145400726.1\|1039922_1040333_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_037574463.1\|1040450_1041023_-	methyltransferase domain-containing protein	A0A2H4PQV0	Staphylococcus_phage	1.8e-60	58.3
WP_145400727.1\|1041019_1041979_-	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	2.2e-63	80.3
WP_145400728.1\|1042090_1043272_+	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	4.5e-135	63.4
WP_145400729.1\|1043635_1046047_+\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	80.2
WP_037574451.1\|1046073_1046385_+	rhodanese-like domain-containing protein	A0A2H4PQR9	Staphylococcus_phage	7.7e-34	69.9
WP_145400731.1\|1046656_1047919_-	aminoacetone oxidase family FAD-binding enzyme	A0A2H4PQX1	Staphylococcus_phage	3.1e-33	77.8

DBSCAN-SWA_2

1158388 : 1167565

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_037574221.1\|1158388_1159384_+	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	7.5e-06	29.9
WP_145400799.1\|1159401_1160427_+\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_165885665.1\|1160445_1161585_+\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.3e-88	45.5
WP_037574211.1\|1161600_1161864_+	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.0e-08	52.6
WP_165885666.1\|1162232_1164512_+	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.4e-28	32.4
WP_165885667.1\|1164752_1167035_+	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	5.3e-71	30.5
WP_037574204.1\|1167046_1167565_+	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	1.2e-26	48.0

DBSCAN-SWA_3

1692613 : 1701040

Prochlorococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_145401094.1\|1692613_1693180_-	phosphoribosylglycinamide formyltransferase	E3SNR5	Prochlorococcus_phage	1.8e-28	38.5
WP_145401095.1\|1693182_1694211_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.0e-61	42.2
WP_145401096.1\|1694215_1695637_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.9e-50	33.4
WP_145401097.1\|1695615_1697805_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	2.1e-133	38.5
WP_145401098.1\|1697797_1698469_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_037571855.1\|1698468_1698738_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_037571857.1\|1698739_1699447_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3HWF9	Synechococcus_phage	2.1e-47	41.6
WP_105963381.1\|1699443_1700571_-	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_145401099.1\|1700557_1701040_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	6.8e-21	43.3

DBSCAN-SWA_4

1850195 : 1902910

Staphylococcus_virus(50.0%)

capsid,portal,head,transposase,holin,plate,terminase,tail,integrase

attL 1865234:1865251|attR 1890889:1890906

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_165885819.1\|1850195_1851653_-	CHAP domain-containing protein	Q4ZCC3	Staphylococcus_virus	3.7e-227	76.0
WP_165885820.1\|1851642_1852068_-\|holin	phage holin	Q8SDS8	Staphylococcus_phage	7.0e-46	66.9
WP_165885821.1\|1852112_1853426_-\|plate	BppU family phage baseplate upper protein	Q4ZC48	Staphylococcus_virus	1.7e-50	57.9
WP_165885822.1\|1853441_1855349_-	CHAP domain-containing protein	Q4ZC50	Staphylococcus_virus	3.6e-283	75.9
WP_165885823.1\|1855488_1855776_-	DUF2951 family protein	A0A1J0MFW4	Staphylococcus_phage	1.6e-25	67.4
WP_165885824.1\|1855822_1855960_-	XkdX family protein	Q4ZCD1	Staphylococcus_virus	7.5e-10	62.8
WP_165885825.1\|1855960_1856305_-	hypothetical protein	Q4ZCD2	Staphylococcus_virus	5.3e-28	52.7
WP_165885826.1\|1856306_1857848_-\|plate	BppU family phage baseplate upper protein	A1BU69	Staphylococcus_virus	2.7e-111	45.0
WP_165885827.1\|1857847_1860511_-	peptidase G2	A0A1W6JQM0	Staphylococcus_phage	0.0e+00	74.8
WP_165885828.1\|1860522_1862376_-	peptidase	Q4ZC57	Staphylococcus_virus	0.0e+00	88.5
WP_165885829.1\|1862387_1863323_-\|tail	phage tail protein	Q4ZC58	Staphylococcus_virus	1.3e-148	83.0
WP_165885830.1\|1863335_1866272_-\|terminase	terminase	Q4ZC60	Staphylococcus_virus	6.8e-265	87.8
1865234:1865251	attL	NA	NA	NA	NA
WP_165885831.1\|1866275_1866560_-	hypothetical protein	Q4ZC61	Staphylococcus_virus	4.9e-43	94.6
WP_165885832.1\|1866604_1867108_-	hypothetical protein	Q4ZC62	Staphylococcus_virus	2.0e-87	96.4
WP_165885833.1\|1867172_1867715_-\|tail	phage major tail protein, TP901-1 family	Q4ZC63	Staphylococcus_virus	2.3e-97	98.3
WP_165885834.1\|1867718_1868141_-	DUF3168 domain-containing protein	Q4ZC64	Staphylococcus_virus	1.7e-71	95.7
WP_165885835.1\|1868152_1868560_-	HK97 gp10 family phage protein	Q4ZC65	Staphylococcus_virus	7.6e-74	95.6
WP_165885836.1\|1868546_1868882_-\|head	phage head closure protein	Q4ZC66	Staphylococcus_virus	5.5e-54	91.0
WP_107370744.1\|1868892_1869243_-\|head,tail	phage head-tail adapter protein	A0A0N6WMR1	Staphylococcus_phage	6.2e-56	88.8
WP_165805170.1\|1869248_1869392_-	hypothetical protein	A0A059T673	Staphylococcus_phage	3.2e-11	76.6
WP_165885837.1\|1869384_1870320_-\|capsid	phage major capsid protein	A0A059T7K3	Staphylococcus_phage	4.4e-165	96.7
WP_165885838.1\|1870336_1870921_-	DUF4355 domain-containing protein	M9NRJ1	Staphylococcus_phage	7.1e-65	86.1
WP_165885839.1\|1871025_1871250_-	hypothetical protein	Q4ZC71	Staphylococcus_virus	2.7e-28	83.6
WP_165885840.1\|1871251_1872205_-\|capsid	minor capsid protein	Q4ZC73	Staphylococcus_virus	2.7e-162	90.8
WP_165885970.1\|1872167_1873598_-\|portal	phage portal protein	A0A0N9BB70	Staphylococcus_phage	2.3e-250	89.7
WP_165885841.1\|1873594_1874818_-\|terminase	PBSX family phage terminase large subunit	A0A059T7K2	Staphylococcus_phage	6.2e-220	88.7
WP_165885842.1\|1874810_1875305_-\|terminase	terminase	A0A0N9BAX3	Staphylococcus_phage	1.1e-53	71.3
WP_165885843.1\|1875758_1876178_-	transcriptional regulator	I1W651	Staphylococcus_phage	3.4e-45	66.2
WP_165885844.1\|1876177_1876327_-	hypothetical protein	Q4ZC01	Staphylococcus_virus	4.8e-18	91.8
WP_107378810.1\|1876448_1876655_-	hypothetical protein	NA	NA	NA	NA
WP_107377318.1\|1876845_1877349_-	dUTPase	A0A1J0MF52	Staphylococcus_phage	4.7e-57	68.7
WP_165885845.1\|1877349_1877709_-	nuclease	Q4ZC06	Staphylococcus_virus	2.2e-56	89.9
WP_165885971.1\|1877695_1877926_-	hypothetical protein	Q4ZC08	Staphylococcus_virus	5.3e-24	84.4
WP_165885846.1\|1878021_1878420_-	hypothetical protein	A0A1J0MFF1	Staphylococcus_phage	1.2e-10	39.9
WP_165885847.1\|1878432_1878645_-	hypothetical protein	Q4ZC11	Staphylococcus_virus	1.5e-20	65.7
WP_165885972.1\|1878644_1878872_-	DUF3310 domain-containing protein	Q4ZC12	Staphylococcus_virus	9.6e-34	94.4
WP_105985981.1\|1878945_1879137_-	hypothetical protein	Q4ZC13	Staphylococcus_virus	1.3e-15	64.1
WP_165885848.1\|1879133_1879553_-	hypothetical protein	Q4ZC14	Staphylococcus_virus	1.4e-22	43.8
WP_037567959.1\|1879554_1879863_-	VRR-NUC domain-containing protein	A0A1X9I642	Streptococcus_phage	1.3e-30	69.0
WP_037567961.1\|1879859_1880063_-	hypothetical protein	H9A0M1	Staphylococcus_phage	4.9e-05	47.3
WP_165885849.1\|1880356_1882675_-	DNA primase	Q8W5V7	Listeria_phage	6.7e-207	48.8
WP_165885850.1\|1882706_1883207_-	DUF669 domain-containing protein	Q8W5V8	Listeria_phage	2.8e-33	44.5
WP_165885851.1\|1883223_1884558_-	DEAD/DEAH box helicase	Q9T1H9	Lactobacillus_phage	1.8e-108	45.5
WP_165885852.1\|1884541_1885252_-	AAA family ATPase	A0A2H4JHD3	uncultured_Caudovirales_phage	2.3e-110	81.9
WP_165885853.1\|1885251_1885470_-	DUF2483 family protein	Q4ZC24	Staphylococcus_virus	2.1e-30	84.7
WP_157950523.1\|1885466_1885733_-	DUF1108 family protein	NA	NA	NA	NA
WP_165885854.1\|1885814_1885991_-	hypothetical protein	Q4ZC27	Staphylococcus_virus	6.3e-09	68.1
WP_107362511.1\|1885980_1886160_-	hypothetical protein	A0A2H4J149	uncultured_Caudovirales_phage	4.3e-13	68.5
WP_057510934.1\|1886260_1886500_+	hypothetical protein	Q4ZC34	Staphylococcus_virus	7.0e-43	98.7
WP_057510935.1\|1886489_1886669_-	hypothetical protein	Q4ZC35	Staphylococcus_virus	4.6e-23	93.2
WP_107372884.1\|1886681_1886927_-	helix-turn-helix transcriptional regulator	A0A1J0MFJ4	Staphylococcus_phage	5.5e-35	92.2
WP_107372887.1\|1887118_1887448_+	helix-turn-helix transcriptional regulator	A0A2H4J641	uncultured_Caudovirales_phage	2.8e-50	92.7
WP_165885855.1\|1887460_1887925_+	ImmA/IrrE family metallo-endopeptidase	A0A2K9VBR7	Staphylococcus_phage	2.0e-54	66.9
WP_165885856.1\|1887940_1888477_+	hypothetical protein	NA	NA	NA	NA
WP_165885857.1\|1888595_1889111_+	hypothetical protein	I6TJR6	Staphylococcus_virus	1.3e-14	65.5
WP_165885858.1\|1889172_1890222_+\|integrase	tyrosine-type recombinase/integrase	A0A1J0MF14	Staphylococcus_phage	2.0e-187	92.0
WP_037572364.1\|1890289_1891687_-	Fe-S cluster assembly protein SufB	NA	NA	NA	NA
1890889:1890906	attR	NA	NA	NA	NA
WP_037572365.1\|1891761_1892211_-	SUF system NifU family Fe-S cluster assembly protein	NA	NA	NA	NA
WP_037573049.1\|1892200_1893442_-	cysteine desulfurase	Q2XUY6	environmental_halophage	1.1e-118	48.7
WP_165885859.1\|1893557_1894865_-	Fe-S cluster assembly protein SufD	NA	NA	NA	NA
WP_037572369.1\|1894886_1895657_-	Fe-S cluster assembly ATPase SufC	A0A2R8FG22	Brazilian_cedratvirus	6.2e-08	28.8
WP_151365144.1\|1895960_1896812_+	DUF368 domain-containing protein	NA	NA	NA	NA
WP_145401258.1\|1897108_1897939_-	methionine ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_037572375.1\|1897963_1898659_-	ABC transporter permease	NA	NA	NA	NA
WP_145401260.1\|1898651_1899680_-	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	1.1e-28	39.0
WP_037572379.1\|1899918_1900239_-	thioredoxin family protein	NA	NA	NA	NA
WP_037572380.1\|1900204_1900600_-	topiosmerase	NA	NA	NA	NA
WP_105985886.1\|1900682_1901063_-	glycine cleavage system protein GcvH	NA	NA	NA	NA
WP_165885860.1\|1901133_1901487_-	arsenate reductase family protein	M1PLC0	Streptococcus_phage	2.2e-21	52.4
WP_145401262.1\|1901656_1901977_+	thioredoxin family protein	NA	NA	NA	NA
WP_145401264.1\|1902068_1902575_-\|transposase	IS3 family transposase	A0A0C5AEA5	Paenibacillus_phage	3.2e-37	50.6
WP_145401266.1\|1902568_1902910_-\|transposase	IS3 family transposase	NA	NA	NA	NA

DBSCAN-SWA_5

1967070 : 1976676

uncultured_Caudovirales_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_145401364.1\|1967070_1969176_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	86.0
WP_037572538.1\|1969147_1969537_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	1.0e-43	64.3
WP_037572541.1\|1970219_1971092_+	DMT family transporter	NA	NA	NA	NA
WP_037572545.1\|1971114_1971615_+	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	2.7e-52	71.5
WP_165885871.1\|1971791_1973303_+	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	1.2e-68	34.6
WP_165885872.1\|1973541_1974468_+	diacylglycerol kinase family lipid kinase	A0A1V0SBJ0	Catovirus	7.5e-08	21.3
WP_037572553.1\|1975028_1975556_-	5'-3'-deoxyribonucleotidase	NA	NA	NA	NA
WP_165885873.1\|1975626_1976676_-	histidinol-phosphate transaminase	A0A1X6WGT4	Pacmanvirus	3.3e-20	26.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP046030

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP046028

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection