CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP050133	Streptococcus cristatus ATCC 51100 chromosome, complete genome	4 crisprs	cas3,DEDDh,csm6,cas1,cas6,DinG,csx1,cas10,csm3gr7,csx19,RT,WYL	0	4	6	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP050133_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050133_1

352275-352370

Orphan

Consensus_repeat	Method
CTCCAGCAGCCAGTGCAGCCCCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050133_1

>merge|NZ_CP050133|1|352275-352370|CRISPRCasFinder
CTCCAGCAGCCAGTGCAGCCCCTGTTGTAGCTCCAGTGCAGCCAGCAAGTGCACCTGTAGCTGAGACGGTTTCCCCAGCAGCCAGTGCAGCCCCTG

>NZ_CP050133|1|1|352275-352370|CRISPRCasFinder
CTCCAGCAGCCAGTGCAGCCCCTG	TTGTAGCTCCAGTGCAGCCAGCAAGTGCACCTGTAGCTGAGACGGTTT
CCCCAGCAGCCAGTGCAGCCCCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050133.1\|WP_045500616.1\|350911_352144_+\|beta-ketoacyl-ACP-synthase-II	unknown	unknown	gnl\|CDD\|235987
NZ_CP050133.1\|WP_009659051.1\|356322_356871_+\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NZ_CP050133.1\|WP_045500641.1\|360884_361646_+\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|183513
NZ_CP050133.1\|WP_045500633.1\|357118_357697_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP050133.1\|WP_045500636.1\|358377_359529_+\|FtsX-like-permease-family-protein	unknown	unknown	unknown
NZ_CP050133.1\|WP_045500602.1\|343885_345253_-\|aspartate-kinase	unknown	unknown	gnl\|CDD\|236364
NZ_CP050133.1\|WP_005591707.1\|348225_349200_+\|enoyl-[acyl-carrier-protein]-reductase-FabK	unknown	unknown	gnl\|CDD\|132195
NZ_CP050133.1\|WP_045500604.1\|345498_346290_+\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|180910
NZ_CP050133.1\|WP_045500638.1\|359556_360024_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240044
NZ_CP050133.1\|WP_005591721.1\|360145_360895_+\|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl\|CDD\|234577
NZ_CP050133.1\|WP_008809611.1\|352635_353058_+\|3-hydroxyacyl-ACP-dehydratase-FabZ	unknown	unknown	gnl\|CDD\|234568
NZ_CP050133.1\|WP_045500627.1\|355369_356140_+\|acetyl-CoA-carboxylase-carboxyl-transferase-subunit-alpha	unknown	unknown	gnl\|CDD\|183435
NZ_CP050133.1\|WP_045500614.1\|350125_350860_+\|3-oxoacyl-[acyl-carrier-protein]-reductase	unknown	unknown	gnl\|CDD\|235500
NZ_CP050133.1\|WP_005591706.1\|347871_348096_+\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|179197
NZ_CP050133.1\|WP_045500624.1\|354509_355373_+\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	unknown	unknown	gnl\|CDD\|235547
NZ_CP050133.1\|WP_045500600.1\|342907_343819_+\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|273359
NZ_CP050133.1\|WP_045500609.1\|346842_347817_+\|ketoacyl-ACP-synthase-III	unknown	unknown	gnl\|CDD\|236475
NZ_CP050133.1\|WP_045500607.1\|346408_346843_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP050133.1\|WP_045500612.1\|349192_350113_+\|ACP-S-malonyltransferase	unknown	unknown	gnl\|CDD\|223408
NZ_CP050133.1\|WP_045500622.1\|353076_354444_+\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	unknown	unknown	gnl\|CDD\|236307

Protein	Function_ID	Function_description	E-value
NZ_CP050133.1\|WP_045500616.1\|350911_352144_+\|beta-ketoacyl-ACP-synthase-II	gnl\|CDD\|235987	PRK07314, PRK07314, beta-ketoacyl-ACP synthase II.	0
NZ_CP050133.1\|WP_009659051.1\|356322_356871_+\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	1.2101e-29
NZ_CP050133.1\|WP_045500641.1\|360884_361646_+\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl\|CDD\|183513	PRK12413, PRK12413, bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase.	3.40177e-170
NZ_CP050133.1\|WP_045500633.1\|357118_357697_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.11095e-05
NZ_CP050133.1\|WP_045500638.1\|359556_360024_-\|NUDIX-domain-containing-protein	gnl\|CDD\|240044	cd04688, Nudix_Hydrolase_29, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	5.11623e-31
NZ_CP050133.1\|WP_045500602.1\|343885_345253_-\|aspartate-kinase	gnl\|CDD\|236364	PRK09034, PRK09034, aspartate kinase; Reviewed.	0
NZ_CP050133.1\|WP_005591707.1\|348225_349200_+\|enoyl-[acyl-carrier-protein]-reductase-FabK	gnl\|CDD\|132195	TIGR03151, enACPred_II, putative enoyl-[acyl-carrier-protein] reductase II. This oxidoreductase of the 2-nitropropane dioxygenase family (pfam03060) is commonly found in apparent operons with genes involved in fatty acid biosynthesis. Furthermore, this genomic context generally includes the fabG 3-oxoacyl-[ACP] reductase and lacks the fabI enoyl-[ACP] reductase.	1.43972e-173
NZ_CP050133.1\|WP_045500604.1\|345498_346290_+\|enoyl-CoA-hydratase	gnl\|CDD\|180910	PRK07260, PRK07260, enoyl-CoA hydratase; Provisional.	3.19293e-178
NZ_CP050133.1\|WP_005591721.1\|360145_360895_+\|tRNA-pseudouridine(38-40)-synthase-TruA	gnl\|CDD\|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	5.15961e-129
NZ_CP050133.1\|WP_008809611.1\|352635_353058_+\|3-hydroxyacyl-ACP-dehydratase-FabZ	gnl\|CDD\|234568	PRK00006, fabZ, 3-hydroxyacyl-ACP dehydratase FabZ.	5.3371e-87
NZ_CP050133.1\|WP_045500627.1\|355369_356140_+\|acetyl-CoA-carboxylase-carboxyl-transferase-subunit-alpha	gnl\|CDD\|183435	PRK12319, PRK12319, acetyl-CoA carboxylase subunit alpha; Provisional.	0
NZ_CP050133.1\|WP_045500614.1\|350125_350860_+\|3-oxoacyl-[acyl-carrier-protein]-reductase	gnl\|CDD\|235500	PRK05557, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Validated.	5.38446e-125
NZ_CP050133.1\|WP_005591706.1\|347871_348096_+\|acyl-carrier-protein	gnl\|CDD\|179197	PRK00982, acpP, acyl carrier protein; Provisional.	2.85946e-20
NZ_CP050133.1\|WP_045500624.1\|354509_355373_+\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	gnl\|CDD\|235547	PRK05654, PRK05654, acetyl-CoA carboxylase carboxyltransferase subunit beta.	5.76391e-174
NZ_CP050133.1\|WP_045500600.1\|342907_343819_+\|EamA-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	9.4339e-29
NZ_CP050133.1\|WP_045500609.1\|346842_347817_+\|ketoacyl-ACP-synthase-III	gnl\|CDD\|236475	PRK09352, PRK09352, beta-ketoacyl-ACP synthase 3.	3.12159e-175
NZ_CP050133.1\|WP_045500607.1\|346408_346843_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	5.06433e-20
NZ_CP050133.1\|WP_045500612.1\|349192_350113_+\|ACP-S-malonyltransferase	gnl\|CDD\|223408	COG0331, FabD, (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism].	7.82477e-127
NZ_CP050133.1\|WP_045500622.1\|353076_354444_+\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	gnl\|CDD\|236307	PRK08591, PRK08591, acetyl-CoA carboxylase biotin carboxylase subunit; Validated.	0

>NZ_CP050133.1|WP_045500616.1|350911_352144_+|beta-ketoacyl-ACP-synthase-II
MKLNRVVVTGYGLTSPIGNTPEEFWNSLKEGKIGIGPITKFDHSDFAVHNAAEVQDFPFDKYFIKKDTNRFDNYSLYALYAAQEAVTNANLDVEAIDKDRFGVIVASGIGGIKEIEDQVIRLHEKGPKRVKPMTLPKALPNMASGNVAMRFGANGICKSINTACASSNDAIGDAFRSIKFGFQDVMLVGGSEASITPFAIAGFQALTALSTTEDPTRASIPFDKDRNGFVMGEGSGMLVLESLEHAEKRGATILAEVVGYGNTCDAYHMTSPHPEGQGAIKAIKLALEEAEISPEQVAYVNAHGTSTPANEKGESGAIVAVLGKEVPVSSTKSFTGHLLGAAGAVEAIATIEAMRHNFVPKTAGTSELSDYIEANVVYGQGLEQEIPYAISNTFGFGGHNAVLAFKRWEG
>NZ_CP050133.1|WP_045500614.1|350125_350860_+|3-oxoacyl-[acyl-carrier-protein]-reductase
MELKNKNVFITGSSRGIGLAIAHKFASAGANIVLNGRGQISDDVLAEFAGYPVKVVAISGDVSDGADAKRMIDEAIVALGSVDVLVNNAGITRDKIMLKMTEEDFEQVLKVNLTGAFNMTQAVLKPMTKARQGAIINLSSVVGLTGNVGQANYAASKAGLIGFSKSVAREVAGRSIRVNVIAPGFIESDMTDGLSEKIKEASLAQIPMKRFGNTEEVADVALFLAGQEYLTGQVIAIDGGLTMQ
>NZ_CP050133.1|WP_045500612.1|349192_350113_+|ACP-S-malonyltransferase
MTKTAFLFAGQGAQYLGMARDLYEQYDVVKATFEEASQVLGYDVRALIDQDEEKLNQTRYTQPAILTTSLSIYRLLAEKGIQPDMVAGLSLGEYSALVAAGALDFKTAVALVAKRGAFMEEAAPAGSGKMVAVLNADVALIEEACQTASQLGVVSPANYNTPGQIVIGGDVAAVDKAVELLKEAGVKRLIPLNVSGPFHTALLKPASEQLARVLAETEFADFQLPLVGNTEADIMETDRIKELLTRQVMEPVRFYDSIAKMQEAGVTEFIEIGPGKVLSGFLKKIDKSAVVYHVESVETLTTLLEK
>NZ_CP050133.1|WP_005591707.1|348225_349200_+|enoyl-[acyl-carrier-protein]-reductase-FabK
MQTRITELLDIKYPIFQGGMAWVADGDLAGAVSKAGGLGIIGGGNAPKEVVKANIDKIKSLTDRPFGVNIMLLSPFVDDIVDLVIEEGVKVVTTGAGNPSKYMARFHEAGITVIPVVPSVALAKRMEKIGADAVIAEGMEAGGHIGKLTTMTLVRQVVEAVNIPVIAAGGIADGSGAAAGFMLGAEAVQVGTRFVVAKESNAHQNYKDMILKARDIDTTISAQHFGHAVRALKNKLTRDFEKAEKEAFKQENPDLTVFENLGAGALANAVVRGDVENGSVMSGQIAGLVSKEETVEEILKDIYYGAAEKIQQEAKRWAGVTRND
>NZ_CP050133.1|WP_005591706.1|347871_348096_+|acyl-carrier-protein
MAVFEKVQEIIVEELGKEPSEVTLESTFDDLEADSLDLFQVISEIEDAFDIQIETEEGLKTVGDLVAYVEEKTK
>NZ_CP050133.1|WP_045500609.1|346842_347817_+|ketoacyl-ACP-synthase-III
MNYARITQVAHYAPEQIVTNDDLAKMMDTSDEWISSRTGIKQRHLSRTESTSDLATKVAEQLLEKAQLSADQLDFIIVATITPDSMMPSTAARVQANIGATKAFAFDLTAACSGFIFALSTGEKFISSGRYQRGLVIGSETLSKVVDWSDRATSVLFGDGAGGVLLEVAEKQHFWAESQFTDGLRGQSLTCGGLGLSSPFSEKQVDDRYLKMEGRAIFDFAIRDVAQSIKNTIEESPFSVEELDYLLLHQANIRILDKMAKKLGVSREKLPANMMEYGNTSAASIPILLSECVQQDLIKLNGDQTILLSGFGGGLTWGTLIVTI
>NZ_CP050133.1|WP_045500607.1|346408_346843_+|MarR-family-transcriptional-regulator
MNYQLVNDYLTSIFNNVLVIEESSLRGSQFKDVSIKEMHTIDVIGTMPNATPSDISKELLVTLGTVTTSLNNLERKGYIERRRSSIDRRVVHLSLTKKGRLLYRLHKRFHNRMVMQVVEGMSSEEKNAMQKGLQNLYNFLEELK
>NZ_CP050133.1|WP_045500604.1|345498_346290_+|enoyl-CoA-hydratase
MTFNGILYKVVDEVATITFNRPEVSNGFNIPMCEEILEAIELAANDEAVNFLVINANGKVFSVGGDLAEMQRAVSADDIQSLVKIAELVNDISFAIKRLPKPVIMSVDGPVAGAAANMVVAADFCIATEKSRFIQAFVGVGLAPDAGGLYLLTRAIGVTRATHLVMTGEALTAEKALDYGLLYKVCEAEKLEKTTEQLLKKLKRGSLNSYRAMKEMVWKSLFSGWKEYAELELALQKSLAFTEDFKEGVQAYTEKRRPQFTGK
>NZ_CP050133.1|WP_045500602.1|343885_345253_-|aspartate-kinase
MKVVKFGGSSLASASQLEKVLHIVKSDAERRFVVVSAPGKRDDQDTKVTDALIKYYRQYIAGNDVSKEQNWIIKRYSDMVSELGLKSAIIEKISKSIISLATLPIENNEFLYDTFLAAGENNNAKLIAAYFNHNGIPARYVHPREAGLVVSSEPGNARILPSSYDKLEELIHSDEVLVIPGFFGVTQDGQICTFSRGGSDITGSIIAAGVKADVYENFTDVDGIFAAHPGIIHKPRSIAELTYREMRELAYAGFTVLHDEALLPAYRGKIPLVIKNTNNPEHPGTRIVHKHSEDHPPVVGIAGDSGFVSINMSKYLMNREVGFGRKALQILEDLNIGWEHMPTGIDDLSIILRERELTPIKEEEILRQLVQKAEVDYAEIEHDLSIIMIVGEKMKSHIGVTATATRALSDNKINIQMMSQGSSEVSIMFVVNKNQEKEAIRALYKAFFGSSESDE
>NZ_CP050133.1|WP_045500600.1|342907_343819_+|EamA-family-transporter
MSKVLRGTLYTLAAGIAWGLSGTSGQYLMEHGFSALSLTNVRLLLAGLVLMMLAYATNKESFKKIWKDKSSLLHILIFAVLGLFINQYAYLAAIHETNAGTATVLQYLCPVGVLAYTCIKDRVTPTVAQVCSMILAIGGTFLIATHGQVNQLSMTPKGLFLGVFSAFTYALYILLPIGLIKKWGSMLVIGIGMTIAGILLLPFSGIFQHQWQVRSDILLALVGIIVIGTIFAYTVFLKGTSLVGPVKSSLLASIEPISAVFFAFVIMNERFYLLDFVGMGMILLAVLLISVKDLILEKKKGLL
>NZ_CP050133.1|WP_008809611.1|352635_353058_+|3-hydroxyacyl-ACP-dehydratase-FabZ
MIDINAIKEALPHRYPMLLVDRVLEVSEDEIVALKNVTINEPFFNGHFPQYPVMPGVLIMEALAQTAGVLELSKEENKGKLVFYAGMDKVKFKKQVVPGDQLIMTAKFVKRRGTIAVVEAKAEVDGKLAASGTLTFAIGQ
>NZ_CP050133.1|WP_045500622.1|353076_354444_+|acetyl-CoA-carboxylase-biotin-carboxylase-subunit
MFRKILIANRGEIAVRIIRAARELGIDTVAVYSTADKEALHTLLADEAVCIGPAKSTDSYLNMNAVLSAAVLTGAEAIHPGFGFLSENSKFATMCEEVGIKFIGPSGAVMDLMGDKINARAQMIKAKVPVIPGSDGEVHTSEEALEVAEKIGYPVMLKASAGGGGKGIRKVEKPEDLVAAFESASSEAKAAFGNGAMYMERVIYPARHIEVQILADQQGHVVHLGERDCSLQRNNQKVLEESPSVAIGKTLRQQIGEAAVRAAESVGYENAGTIEFLLDEAKGEFYFMEMNTRVQVEHPVTEFVTGVDIVKEQIKIADGQELSFSQEDVEIRGHAIECRINAENPAFNFAPSPGKISNLYLPSGGVGLRVDSAVYPGYTIPPYYDSMIAKIIVHGENRFDALMKMQRALYELEIDGVVTNSSFQLDLISDPNVIAGDYDTAFLMEKFLPAYQEKK
>NZ_CP050133.1|WP_045500624.1|354509_355373_+|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta
MPLFSKKDKYIRINPNRSSRALPQPKPEVPDELFSKCPGCKHTIYQKDLGAERVCPSCGYTFRISAFERLSLTVDEGSFEELFTGIETTDPLHFPNYQEKLAKMREKTGLDEAVLTGIALIKGQKLALGIMDSNFIMASMGTIVGEKITRLFEYATEHQLPVVLFTASGGARMQEGIMSLMQMAKTSAAVQRHSKAGLFYLTVLTDPTTGGVTASFAMEGDIILAEAQALVGFAGRRVIESTVREKLPDDFQKAEFLLEHGFVDAIVKRGELRDRIATLLRFHGGDQ
>NZ_CP050133.1|WP_045500627.1|355369_356140_+|acetyl-CoA-carboxylase-carboxyl-transferase-subunit-alpha
MTKISQIIKAARDQSRLTALDFAQGIFDDFVELHGDRGFRDDGAVIGGIGTLNGQPVTVVGIQKGRNLQDNLRRNFGQPHPEGYRKALRLMKQAEKFGRPVVTFINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGGALALAVADKVWMLENSMYAILSPEGFASILWKDGSRAMEAAEMMKITSHELLQMGVVDKVIPERGFNKNELLAAVKQEISTELAELSKLSLEQLLEDRYQRFRKY
>NZ_CP050133.1|WP_009659051.1|356322_356871_+|carboxymuconolactone-decarboxylase-family-protein
MSEFTIHTIESAPAEVKEVLETVQKDNGGYIPNLIGLLANAPTALETYRTVGAINRRNSLTPTEREVVQITAAVTNGCAFCVAGHTAFSIKQIQMNDDLLEALRNRTPIDTDPKLDTLAKFTIAVINTKGRVGDEALADFLEAGYTHENALDVVLGVSLATLCNYANNLANTPINPELQPYA
>NZ_CP050133.1|WP_045500633.1|357118_357697_+|TetR/AcrR-family-transcriptional-regulator
MPPKNKFTRDEIIQAALGIVREDGLAGLTARSLAERLQSSPKVIFGQFENMEDLSHSVVRAAEFVLVQYIRSALERAKPFRAVGMAYILFASQEPQLFKILYLNPHKHPIESFKDFLPQKDHSYQQILESIVEDYPMPIESAEFVYQHLFIYSHGLASMIASGIYSFSQEEVTERLTQVFTALLKEMKGKQE
>NZ_CP050133.1|WP_045500636.1|358377_359529_+|FtsX-like-permease-family-protein
MFSIKDLYRLVVVSIISFCAVFVTNLFLNFYLDIRLLDQTNWLPEIRAAYDAQVAISWLIASISGAVLSLTSILLLFFYIRQFIDQHKPELGVLKALGYKNWEIARKFWLFSLPIGLGTGTGYFSSFAMMPHFYQLRNQSGVLPEITIRQHWSLFLFLVVLPTLSFAALAVLYASYCLRLPALDLLKRVSPSRKPPKRKTVKQIRKDRPFLKDLSASLLWSRKLLIFFVIFGSMCFSAMIQLSFGMKELTDETIQIMMMSIGTVLSVAILYLSLGVLLQENQETLAIMKVFGYSRNECHKSLFAPYRILAFLGFVLGTGYQYGIMQLLLRLMEKSIAQKVDYDFDFGVCLMTLLVFVLVYESLIYLSNRRIDQLTIKQVMLGE
>NZ_CP050133.1|WP_045500638.1|359556_360024_-|NUDIX-domain-containing-protein
MAKDISYTQGQERFRYRAAAIIIEEEALCVMSSSSEDYFYSVGGAVRFGETSKEAVQREVFEETGQKYEIEKLAFVHENLFSNSTGILKGLDCHEICFYYLMKPHGKQFDYQHKQEQVYWIPLTDLENYKVFPKEITHILKHLQTGIQHIISKKE
>NZ_CP050133.1|WP_005591721.1|360145_360895_+|tRNA-pseudouridine(38-40)-synthase-TruA
MTRYKALISYDGHDFAGFQRQPHARSVQEEIEKTLTRINKGQPIVIHGAGRTDSGVHALGQVIHFDLPSARDEEKLRFALDTQTPEDIDVISVEEVTEDFHARYKPHSKTYEFLVDIGRPKNPMMRHYATHYPYPLEIPLMEQAIKALEGTHDFTGFTASGTSVENKVRTITKASLTFDAQRNFLVFTFSGNGFLYKQIRNMVGTLLKIGNKRMPVNQIERILEEKDRQLAGPTAAPNGLYLKEIIYEE
>NZ_CP050133.1|WP_045500641.1|360884_361646_+|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MKNKLILALSGNDIFSGGGLHADLATYTVHGLHGFVAVTCLTAMTDKGFEVLPTDEQVFAQQLSSLKDVPFSAIKLGLLPTVAIADQALDFIKKQAGIPAVLDPVLVCKETHDVEVSALRDELIKFFPYTTIITPNLPEAEILTQSDIKSLDDLKAAAVTLHELGAQNVVIKGGNRFNQDQALDLFYDGKDFVLLESPVLPNNNTGAGCTFASSIASQLLAGQSPLEAVNYSKDFVYRAIQRSDQYGVIQYEK

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Crispr_ID: NZ_CP050133_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050133_2

582743-582834

Orphan

Consensus_repeat	Method
TTAAATCAACACTTTGTTGATTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050133_2

>merge|NZ_CP050133|2|582743-582834|CRISPRCasFinder
TTAAATCAACACTTTGTTGATTTTTGATTATTGCTTTTTGTCTAAGCTCATTATATAATATCTGTGATTTAGAATCAACACTTTGTTGATTT

>NZ_CP050133|2|2|582743-582834|CRISPRCasFinder
TTAAATCAACACTTTGTTGATTT	TTGATTATTGCTTTTTGTCTAAGCTCATTATATAATATCTGTGATT
TAGAATCAACACTTTGTTGATTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050133.1\|WP_045501067.1\|588867_589374_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|223427
NZ_CP050133.1\|WP_045501049.1\|579790_580633_+\|C39-family-peptidase	unknown	unknown	gnl\|CDD\|379241
NZ_CP050133.1\|WP_045501045.1\|577975_578755_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
NZ_CP050133.1\|WP_045501057.1\|582867_583569_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224059
NZ_CP050133.1\|WP_037586201.1\|592821_593622_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293819
NZ_CP050133.1\|WP_045501055.1\|582161_582725_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP050133.1\|WP_045501071.1\|590770_591472_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP050133.1\|WP_045501047.1\|578767_579163_+\|DUF948-domain-containing-protein	unknown	unknown	gnl\|CDD\|227109
NZ_CP050133.1\|WP_045501065.1\|587974_588832_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|225312
NZ_CP050133.1\|WP_045501044.1\|577047_577983_+\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
NZ_CP050133.1\|WP_045501042.1\|576412_576904_+\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239217
NZ_CP050133.1\|WP_045501061.1\|586389_587238_+\|metallophosphoesterase-family-protein	unknown	unknown	gnl\|CDD\|378975
NZ_CP050133.1\|WP_045501053.1\|581102_582032_+\|U32-family-peptidase	unknown	unknown	gnl\|CDD\|223896
NZ_CP050133.1\|WP_045501069.1\|589425_590508_-\|aminopeptidase-P-family-protein	unknown	unknown	gnl\|CDD\|223085
NZ_CP050133.1\|WP_005589465.1\|579178_579610_+\|YtxH-domain-containing-protein	unknown	unknown	gnl\|CDD\|378938
NZ_CP050133.1\|WP_045501059.1\|583570_586294_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|223650
NZ_CP050133.1\|WP_005589490.1\|591464_592829_+\|cell-wall-metabolism-sensor-histidine-kinase-VicK	unknown	unknown	gnl\|CDD\|380162
NZ_CP050133.1\|WP_002931101.1\|587295_587748_+\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224870
NZ_CP050133.1\|WP_080940906.1\|575977_576271_+\|PspC-domain-containing-protein	unknown	unknown	gnl\|CDD\|224894
NZ_CP050133.1\|WP_045501051.1\|580682_580973_-\|DUF3270-domain-containing-protein	unknown	unknown	gnl\|CDD\|371663

Protein	Function_ID	Function_description	E-value
NZ_CP050133.1\|WP_045501067.1\|588867_589374_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl\|CDD\|223427	COG0350, Ada, Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	1.23537e-49
NZ_CP050133.1\|WP_045501049.1\|579790_580633_+\|C39-family-peptidase	gnl\|CDD\|379241	pfam13529, Peptidase_C39_2, Peptidase_C39 like family.	7.71886e-19
NZ_CP050133.1\|WP_045501045.1\|577975_578755_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	2.80113e-97
NZ_CP050133.1\|WP_045501057.1\|582867_583569_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	1.82975e-102
NZ_CP050133.1\|WP_037586201.1\|592821_593622_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293819	cd07733, YycJ-like_MBL-fold, uncharacterized subgroup which includes Bacillus subtilis YycJ and related proteins; MBL-fold metallo hydrolase domain. Includes the uncharacterized Bacillus subtilis YycJ protein. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	1.21045e-83
NZ_CP050133.1\|WP_045501055.1\|582161_582725_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	4.53848e-09
NZ_CP050133.1\|WP_045501071.1\|590770_591472_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	5.42215e-93
NZ_CP050133.1\|WP_045501047.1\|578767_579163_+\|DUF948-domain-containing-protein	gnl\|CDD\|227109	COG4768, COG4768, Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only].	2.92743e-33
NZ_CP050133.1\|WP_045501065.1\|587974_588832_+\|VOC-family-protein	gnl\|CDD\|225312	COG2514, COG2514, Predicted ring-cleavage extradiol dioxygenase [General function prediction only].	1.19228e-94
NZ_CP050133.1\|WP_045501044.1\|577047_577983_+\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	5.37228e-168
NZ_CP050133.1\|WP_045501042.1\|576412_576904_+\|NUDIX-hydrolase	gnl\|CDD\|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	6.34851e-14
NZ_CP050133.1\|WP_045501061.1\|586389_587238_+\|metallophosphoesterase-family-protein	gnl\|CDD\|378975	pfam12850, Metallophos_2, Calcineurin-like phosphoesterase superfamily domain. Members of this family are part of the Calcineurin-like phosphoesterase superfamily.	6.6717e-17
NZ_CP050133.1\|WP_045501053.1\|581102_582032_+\|U32-family-peptidase	gnl\|CDD\|223896	COG0826, COG0826, Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones].	3.38165e-90
NZ_CP050133.1\|WP_045501069.1\|589425_590508_-\|aminopeptidase-P-family-protein	gnl\|CDD\|223085	COG0006, PepP, Xaa-Pro aminopeptidase [Amino acid transport and metabolism].	1.87155e-124
NZ_CP050133.1\|WP_005589465.1\|579178_579610_+\|YtxH-domain-containing-protein	gnl\|CDD\|378938	pfam12732, YtxH, YtxH-like protein. This family of proteins is found in bacteria. Proteins in this family are typically between 100 and 143 amino acids in length. The N-terminal region is the most conserved. Proteins is this family are functionally uncharacterized.	7.28592e-11
NZ_CP050133.1\|WP_045501059.1\|583570_586294_+\|FtsX-like-permease-family-protein	gnl\|CDD\|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	1.10995e-17
NZ_CP050133.1\|WP_005589490.1\|591464_592829_+\|cell-wall-metabolism-sensor-histidine-kinase-VicK	gnl\|CDD\|380162	NF033093, HK_VicK, cell wall metabolism sensor histidine kinase VicK. This model describes the protein VicK (or WalK) as found in Streptococcus pneumoniae, This protein is shorter than the WalK of Staphylococcus aureus, although apparently is functionally similar. Compare to model NF033092 (HK_WalK). VicK is a sensor histidine kinase involved in regulating cell wall metabolism. Its two component system partner is the response regulatory VicR.	0
NZ_CP050133.1\|WP_002931101.1\|587295_587748_+\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	1.13339e-32
NZ_CP050133.1\|WP_080940906.1\|575977_576271_+\|PspC-domain-containing-protein	gnl\|CDD\|224894	COG1983, PspC, Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms].	1.41485e-17
NZ_CP050133.1\|WP_045501051.1\|580682_580973_-\|DUF3270-domain-containing-protein	gnl\|CDD\|371663	pfam11674, DUF3270, Protein of unknown function (DUF3270). This family of proteins with unknown function appears to be restricted to Streptococcus.	2.23088e-17

>NZ_CP050133.1|WP_045501055.1|582161_582725_-|TetR/AcrR-family-transcriptional-regulator
MVQKRKTSTKEDIKEALIQLLSEERFDNISISKLCKRAGINRGTFYLHYQDKYQMVESLKSDIISQLYSYSLFEEEGEYSKRFMIAKFHILRANERLINALTRSHYIDFRGAIREFITSIILSDKQKAATQRFLEENFHIPQKYALEIFLSSVEGIISLWIAGGAQEKPEEITQMILATYNYDYWKS
>NZ_CP050133.1|WP_045501053.1|581102_582032_+|U32-family-peptidase
MKKIIITATAESIEQVQALLEAGVDRIYVGEEKYGLRLPHNFTYDELNRISQMVHQAGKEVTVAVNALMHQDMMDQIKPYLDFLQEIEVDYITVGDAGVFYVLQRDGYKLKTIYDASTMVTSSRQINFWGKNAGVSEAVLAREIPSAELFKMPEILEIPAEVLVYGASVIHHSKRPLLQNYYNFTHIDDAKSRERDLFLAEPSDPQSHYSIFEDKHGTHIFANNDLDLMTKLIELVDHGFTHWKLEGLYTPGQNFVEIAKLFVQARDLIEKGEFSHDQAFLLDEPLHKLHPKNRFLDTGFYDYDPDMVK
>NZ_CP050133.1|WP_045501051.1|580682_580973_-|DUF3270-domain-containing-protein
MAVRDFKQFESAPLHDSTEQTKEVSYQEYLPQAESASQLRELFFFINIALFCILTVFFSFIFLSAKISTFLSFTLAVVLSLMVIQGYRTVRRKKRR
>NZ_CP050133.1|WP_045501049.1|579790_580633_+|C39-family-peptidase
MKNLKVLALLGLGCCLLACSRQKASESPQSRSSDSSSKASSTSQARSKTASSSQSSANQSIPSQSSTSTESESSSQTSEKAREEETQPSSKEASSPIRKRLEVPMQIQRAWNTCAPTSVSMILAYRGVQASQEELARAMGTDETFGTHNVNVIRVLNQYLFGYAEVPAGQAGYHLGTVTSSASNSEDMRLFKERLRKNIDDGYPLYYTIDNASIYPGHKGEHNVVGTGYELSADGSDILAVYYIDPSYTVQDPVYGGLKKVTPEELLAAMCACQEPNYAW
>NZ_CP050133.1|WP_005589465.1|579178_579610_+|YtxH-domain-containing-protein
MGKISSLLLGAVSGAAAAYFLTSKKGKEITEKVQDFVVDYREDPDKTHEAVVQSVKDFSDQAVKAINQTKEKVENGEITAETVLESVKDTTKSVVDYSQDKFQEIKEKFEKEEEILEEEISDIVVEEGEKAPSEEIIIDLEDK
>NZ_CP050133.1|WP_045501047.1|578767_579163_+|DUF948-domain-containing-protein
MLEIAYTLVAVALIVFLIYLTLTVKTLGDKAAKMLDETENTIKVLTSDVNVTLHQTNDLIAKVNVLTDDINHKVATIDPLFNAVADLSESVSDLNDQARVLGKKAVAAGSTTAKTTAGLTALRLFTKLFKK
>NZ_CP050133.1|WP_045501045.1|577975_578755_+|prolipoprotein-diacylglyceryl-transferase
MLDPVAFSVGPFSIRWYAICIVTGLILAVYLAMKEAPRKKMIPDDILDFILIAFPLAILGARLYYVIFEWSYYGKHSLIEIFQIWNGGLAIYGGLITGALVLYFFSQRRLINPVDFLDIAAPSVLIAQSIGRWGNFFNQEAYGAVVKNLNYLPSFIRNNMYIDGAYRQPTFLYESLWNLLGFALLLILRRRPKFFHQGELAAFYLIWYGFGRMIIEGMRTDSLMFLGIRVSQWLSAALILLGIGIMIYQRKKQAPYYQE
>NZ_CP050133.1|WP_045501044.1|577047_577983_+|HPr-kinase/phosphorylase
MSVKVKDLIEKVRLRIVYGSDDLLEKEISTSDISRPGLEMTGYFDYYTPERIQLIGMKEWSYLMKMTSHNRHQVLLKMFQPETPVAIVARNLEIPEEMRRAAEEKQIAILTSRTSTSRLSGEISSFLDSRLAVRTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDIFAKDEMTLWGEPAEILRHLLEIRGVGIIDVMSLYGASAVKDSSQVQIAVYLENYDTNKTFDRLGNNAEELEVSGVRIPRIRIPVKTGRNISVVIEAAAMNYRAKEMGFDATKIFEERLTNLISQNEVKDA
>NZ_CP050133.1|WP_045501042.1|576412_576904_+|NUDIX-hydrolase
MTEVWNAYDLNRNQLPHLLVRGENIPEGQFHLCVNVLVRHQDGDILFMRRSANKSLYPGYYEFGAGGSVLAGEDSLTAALRELEEETGLVPDSIRLLEQVCSVEDQCHFDFYEAVVSSDKNQVRYQAGETDAHLWLPLNEIPVFIESHPCFQNQKRILKKWIG
>NZ_CP050133.1|WP_080940906.1|575977_576271_+|PspC-domain-containing-protein
MRVEVIIMKTKFYKLRRNRVISGVLSGLADKFNFDLGLLRFLFIIFTVSNLGLGILIYILLAVVMPYKEDVEAEMYGTGPRKMKDAEPINDNDGWFW
>NZ_CP050133.1|WP_045501057.1|582867_583569_+|ABC-transporter-ATP-binding-protein
MAYIEMKHSFKRYQVGDTGIVANHDISFEIEKGELVIILGASGAGKSTVLNILGGMDTNDEGDILIDGQNIADYNSHQLTDYRRNDVGFVFQFYNLVPNLTAKENVELASEIVKDAQDPVAALTAVGLEKRLNNFPAQLSGGEQQRVSIARAVAKNPKILLCDEPTGALDYNTGKQVLQILQDMSRNQGATVIIVTHNAALAPIADRVIRMHDARVKSVTVNEEPQDISTLEY
>NZ_CP050133.1|WP_045501059.1|583570_586294_+|FtsX-like-permease-family-protein
MKRKIYWKDILRSFTSSKGRFLSILILMMLGSLALVGLKFAPPNMRRTATDYLKEQRTMDLAVMADYGLDKADQKELEAIKGADVEFGYLTDVTVDEEALRVFSDTKDISNFQVTSGRLPKNEQEIALASFWSKKYKLGQEIDLTEKAGSRSVLKNKTYKIVGFVNSAELWSDRNLGNTTSGSGALSAYAVVSPKAFDTDVYSIARLRYHDLEKLAPFSESYQEHLEQHQTALDKSLEDNGVARFKRLEADAKSTIQKGQDKIAQAESELTQGKKQLEQAQSQLDQQKSQLEVAQAASILAPDQLGQSRQQIQEAESQLNQKKSELAQAEKDLSANKDKLADAKANLSRLKEPAYHSYDRKSLPGGNGYHMYKNSMNSIASIGNIFPVVLYLVAAMVTFTTITRFVDEERTNAGVFKALGYHSRDIIRKFALYGLVAGSLGTLIGILLGHYFLSGVISSIITRGMVLSVPHAYFYVSYSILALGLSLLSSVLPAYLVARRELTEEAAHLLLPKPPVKGSKIFLERLPFIWRRLSFTQKVTARNIFRYKQRMFMTIFGVAGSVALLFAGLGLQSSIGGIPKRQFEEILRYDLIVAANPGENQAEQDKLKKMLADDSIAAYQEIHSETLTEKYKGKKETESVTLMVTDKENFKPFISMESPDSRQKLSLKDGAVVSDKLARIAGVSPGGSIELGGKSVKLAAVNENHFGHFAFMKATDYQKIYGKKPEKNAYLVRLKDSSSKNIVDKANEFMSLKSVKSVSQNASMVQQFNVLANSLNNTMMILVLISILLAVVILYNLTNINVAERIRELSTIKVLGFHNKEVTLYIYRETIILSVIGMAVGLLGGFFLHRFLIEKVAPSIISLNPQVSPSVYLFPLTAVTLILTLLGFFVNYRFRRVDMLEALKSVD
>NZ_CP050133.1|WP_045501061.1|586389_587238_+|metallophosphoesterase-family-protein
MTRKIALLSDVHGNSTALEAVLADAESQQVTDYWFLGDLLLPGTGRRNILDRMEQLPISLQVRGNWEDSLWHALHQKLDLDRPSHLYLTRLCHFVLEKIRPEEIDHMQELPLQILTEVEGLKIAVSHHLPDKNWGRELIHIGEQSDFDRLFEGNDCAVAVYGHIHQQFLRYGTKGQLIINPGSIGQPFFLDSTLRQDLRAQYAILEIDETGLADVDLRRVAYDVEQELRLARELHLPYYEIYRESLVNGIHHTHNHDLLREISEREGYADEIAAFLKSGRNS
>NZ_CP050133.1|WP_002931101.1|587295_587748_+|Rrf2-family-transcriptional-regulator
MQISSRFTIATHMLIVLALEGKKQKLTSDILAGSVGVNPVIIRKTLSQLKNAGMITVARGTGGAEIAKDLKDISLLDVYSAVECLGKSGQLFSFHDKPNPDCPIGKNIHNVLDDRLAAIQAAMEAELAQTSLDEVVAATEKEIKEQSVSQ
>NZ_CP050133.1|WP_045501065.1|587974_588832_+|VOC-family-protein
MTFEYQSKIYLGEVALYVADLARQKDFYQRVLGLELLEEQDGQVALGRDGQVLVRLLATSDRQTVKSAYGLYHLALLLPSRQALADILKHLSENKVPMVGGADHGYSEAIYLEDPEGNGIELYRDKPQADWDIREDGRIIGVTEALAAQEIYELGQEIQPFSIAEGTRMGHVHLSVKNSRAASHFYQKLLGLEDKFSVPSASWLASGNYHHHLAVNEWGGSHLNHRQPKQLGLAYFEAQVEGKEDLVAIYENAQVLQAPVRWISSQELEVTDPDGIVAKIKTRVV
>NZ_CP050133.1|WP_045501067.1|588867_589374_+|methylated-DNA--[protein]-cysteine-S-methyltransferase
MYKTYYTSPIGRILILTDSNALLGLWLEGQKYFGAGYDLEQAEEEETEVSRRVFAWLDAYFKGENPAINEIPLAPQVTEFRSKVLTVLQKIPYGQTATYSDILRELQAEYGKIGSARAVGGAIGHNPISLLIPCHRIVGSDGKLTGYAGGLDKKAFLLKLEAGEKTTG
>NZ_CP050133.1|WP_045501069.1|589425_590508_-|aminopeptidase-P-family-protein
MTKINQIITYLENEKQDVAVISDPVTIHYLTGFYSDPHERQMFLFVYTDHEPLLFVPALEVERASSTVDFQVIGYVDSENPWEKIKASLPSQSFKQVAVEFDNLILTKYHGLRTVFNGAEFVNLTPYINRLRLIKSADEIQKMLVAGQYADKAVNIGFDNISLENTETDIIAQIDFAIKREGYEMSFETMVLTGNNAANPHGIPGANKIENNALLLFDLGCMVNGYASDMTRTVAVGQPDQFKKDIYYLTLEAQQAALDFIKPGVTAHEVDRAAREVIEKAGYGEYFNHRLGHGIGMDVHEFPSIMEGNDMVIEEGMCFSVEPGIYIPGKVGVRIEDCGYVTKNGFELFTETSKDLLYFD
>NZ_CP050133.1|WP_045501071.1|590770_591472_+|response-regulator-transcription-factor
MKKILVVDDEKPISDIIKFNMAKEGYEVLTAFDGKEALEMFEAEQPDILILDLMLPEVDGLDVARTIRKTSNVPIIVLSAKDSEFDKVIGLEIGADDYVTKPFSNRELLARVKALLRRSELVPDSHVDESSPKELFIGDLQILPDAFVVKKHGKELELTHREFELLHHLATHVGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYIRNND
>NZ_CP050133.1|WP_005589490.1|591464_592829_+|cell-wall-metabolism-sensor-histidine-kinase-VicK
MIETLKEFVLSPDFVFSLIVVGFIIVVALLLLENRRDTQKLVQLNQKIKGLIAGDYSEVLDMQGSPEITDMTNSINDLSEVIRLTHENLEQETKRLSSILSYMTDGVLATNRRGQIITINDMATKQLGVKRDDVLNTSILDLLDIADEYDLRELITKVPELTIDSQDENGEYVSLRVRFALIRRESGFISGLVAVLHDTTEQDKEERERRLFVSNVSHELRTPLTSVKSYLEALDDGALSEPVAPEFVKVSLTETNRMMRMVTDLLSLSRIDNNTSHLDVELTNFTAFITYILNRFDKIKNQDETKKYEIIRDYSITPIWVEIDTDKMTQVIDNIMNNAIKYSPDGGTITVSVRTTDVQLILSISDEGLGIPKQDLPKIFDRFYRVDKARSRAQGGTGLGLAIAKEIIKQHHGFIWAKSEYGKGSTFTIVLPYDNDAVRVDDWENEENVESEHD
>NZ_CP050133.1|WP_037586201.1|592821_593622_+|MBL-fold-metallo-hydrolase
MTKGFQYSILASGSSGNCFYLETDQKRLLVDAGLSGKKITSLLSEIDRKPEDLDAILVTHEHKDHIHGVGVLARKYNLDIYANEATWRAMEKDLGKLDASQKHIFEMGKMKTFGDLDVESFGVSHDAAAPQFYRFMKDGKSFVMLTDTGYVSDRMAGVIENADAYLIESNHDIEILRSGAYPWSLKQRILSDLGHLSNEDGAETMIRTLGNRTKRIYLGHLSKENNIKELAHMTMVNQLAQADLPVGHDFQVFDTSPDTATPLVNI

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Crispr_ID: NZ_CP050133_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050133_3

710261-711094

TypeIII-A

Consensus_repeat	Method
GNTNNNANCCCCCTAANCCTCGNGAGGGGACGGAAAC	CRT
CTAATCCTCGCGAGGGGACGGAAAC	CRISPRCasFinder

11 spacers

cas1,csm6,cas6

The CRISPR arrays of NZ_CP050133_3

>merge|NZ_CP050133|3|710261-711094|CRT,CRISPRCasFinder
GTTAGACCCCCCCTAAACCTCGAGAGGGGACGGAAACTTCCTGTTCTACCGTCAATCCAGCCGCTTTCGCTTTGGTTAGCCCCCCCCTAAACCTCGCGAGGGGACGGAAACAATCATCTTTGTAATGCTAAAGTGAAATTCCTTATCGGTTAGAACCCACTAATCCTCGCGAGGGGACGGAAACCCAGCCTCGTCAGTTTGACCGATGGCCATGTAATTGGTTAGAACCCCCTAATCCTCGAGAGGGGACGGAAACTCATTAAGCCTGTTAATCTTGATGATTGCTGCCATCGTTAGAACCCCCTAATCCTCGAGAGGGGACGGAAACGAAACGTATAGTCTCGCACAGATACCATTTCAAACGTTAGACCCCCCTAATCCTCGCGAGGGTACGGAAACGGAGCACGGCGGACATTGATAGCATCCACAGTCAGGTTAGACCCCCCTAAACCTCGCGAGGGGACGGAAACAATCATCTTTGTAATGCTAAAGTGAAATTCCTTATCGGTTAGAACCCACTAATCCTCGCGAGGGGACGGAAACAAATTGACGACGACCATTGATGATGACAGGGCGCTTTGTTAGAACCCCCCTAATCCTCGCGAGGGGACGGAAACTCAACTGCTCTAGAGTGAGTATCATTGTAGTAAGAGTTAGAACCCTCCATATCCTCGAGAGGGAACGGAAACGGATTTGCTGATTTTGCTTGTCGATAGTCTGCATGCTGTTAGATCCCCCAAACCCTCGCGAGGGGACGGAAACTCATTTTGGTAATCGGTCATTGGTTTACCGATTTTGTTAGCCCCCTCCTAAACCTCGAGAGGGGACAGAGTA

>NZ_CP050133|3|1|710261-711094|CRT
GTTAGACCCCCCCTAAACCTCGAGAGGGGACGGAAAC	TTCCTGTTCTACCGTCAATCCAGCCGCTTTCGCTTTG
GTTAGCCCCCCCCTAAACCTCGCGAGGGGACGGAAAC	AATCATCTTTGTAATGCTAAAGTGAAATTCCTTATC
GGTTAGAACCCACTAATCCTCGCGAGGGGACGGAAAC	CCAGCCTCGTCAGTTTGACCGATGGCCATGTAATT
GGTTAGAACCCCCTAATCCTCGAGAGGGGACGGAAAC	TCATTAAGCCTGTTAATCTTGATGATTGCTGCCAT
CGTTAGAACCCCCTAATCCTCGAGAGGGGACGGAAAC	GAAACGTATAGTCTCGCACAGATACCATTTCAAA
CGTTAGACCCCCCTAATCCTCGCGAGGGTACGGAAAC	GGAGCACGGCGGACATTGATAGCATCCACAGTCA
GGTTAGACCCCCCTAAACCTCGCGAGGGGACGGAAAC	AATCATCTTTGTAATGCTAAAGTGAAATTCCTTATC
GGTTAGAACCCACTAATCCTCGCGAGGGGACGGAAAC	AAATTGACGACGACCATTGATGATGACAGGGCGCTTT
GTTAGAACCCCCCTAATCCTCGCGAGGGGACGGAAAC	TCAACTGCTCTAGAGTGAGTATCATTGTAGTAAGA
GTTAGAACCCTCCATATCCTCGAGAGGGAACGGAAAC	GGATTTGCTGATTTTGCTTGTCGATAGTCTGCATGC
TGTTAGATCCCCCAAACCCTCGCGAGGGGACGGAAAC	TCATTTTGGTAATCGGTCATTGGTTTACCGATTTT
GTTAGCCCCCTCCTAAACCTCGAGAGGGGACAGAGTA

>NZ_CP050133|3|3|710273-711094|CRISPRCasFinder
CTAAACCTCGAGAGGGGACGGAAAC	TTCCTGTTCTACCGTCAATCCAGCCGCTTTCGCTTTGGTTAGCCCCCCC
CTAAACCTCGCGAGGGGACGGAAAC	AATCATCTTTGTAATGCTAAAGTGAAATTCCTTATCGGTTAGAACCCA
CTAATCCTCGCGAGGGGACGGAAAC	CCAGCCTCGTCAGTTTGACCGATGGCCATGTAATTGGTTAGAACCCC
CTAATCCTCGAGAGGGGACGGAAAC	TCATTAAGCCTGTTAATCTTGATGATTGCTGCCATCGTTAGAACCCC
CTAATCCTCGAGAGGGGACGGAAAC	GAAACGTATAGTCTCGCACAGATACCATTTCAAACGTTAGACCCCC
CTAATCCTCGCGAGGGTACGGAAAC	GGAGCACGGCGGACATTGATAGCATCCACAGTCAGGTTAGACCCCC
CTAAACCTCGCGAGGGGACGGAAAC	AATCATCTTTGTAATGCTAAAGTGAAATTCCTTATCGGTTAGAACCCA
CTAATCCTCGCGAGGGGACGGAAAC	AAATTGACGACGACCATTGATGATGACAGGGCGCTTTGTTAGAACCCCC
CTAATCCTCGCGAGGGGACGGAAAC	TCAACTGCTCTAGAGTGAGTATCATTGTAGTAAGAGTTAGAACCCTC
CATATCCTCGAGAGGGAACGGAAAC	GGATTTGCTGATTTTGCTTGTCGATAGTCTGCATGCTGTTAGATCCCC
CAAACCCTCGCGAGGGGACGGAAAC	TCATTTTGGTAATCGGTCATTGGTTTACCGATTTTGTTAGCCCCCTC
CTAAACCTCGAGAGGGGACAGAGTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050133.1\|WP_045496603.1\|719630_721157_+\|membrane-protein	unknown	unknown	gnl\|CDD\|274774
NZ_CP050133.1\|WP_045496587.1\|713177_713993_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050133.1\|WP_045496598.1\|717006_717945_+\|dihydroorotate-dehydrogenase	unknown	unknown	gnl\|CDD\|235982
NZ_CP050133.1\|WP_045496595.1\|716187_716994_+\|dihydroorotate-dehydrogenase-electron-transfer-subunit	unknown	unknown	gnl\|CDD\|234601
NZ_CP050133.1\|WP_045496576.1\|707110_707887_+\|hypothetical-protein	csm6	cd09746_csm6_CAS-III-A	gnl\|CDD\|312974
NZ_CP050133.1\|WP_045496563.1\|703501_704179_+\|ribose-5-phosphate-isomerase-RpiA	unknown	unknown	gnl\|CDD\|234816
NZ_CP050133.1\|WP_166492631.1\|708667_709618_+\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187766
NZ_CP050133.1\|WP_045496555.1\|700877_701063_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050133.1\|WP_005589648.1\|718888_719518_+\|orotate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234771
NZ_CP050133.1\|WP_045496579.1\|707879_708611_+\|NAD-dependent-protein-deacylase	unknown	unknown	gnl\|CDD\|234777
NZ_CP050133.1\|WP_045496592.1\|715011_715977_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050133.1\|WP_045496590.1\|714138_714984_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050133.1\|WP_045496569.1\|705429_706242_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|236183
NZ_CP050133.1\|WP_045496572.1\|706400_707108_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NZ_CP050133.1\|WP_045496601.1\|718148_718841_+\|orotidine-5'-phosphate-decarboxylase	unknown	unknown	gnl\|CDD\|234695
NZ_CP050133.1\|WP_052687620.1\|702657_703272_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367814
NZ_CP050133.1\|WP_045496566.1\|704192_705404_+\|phosphopentomutase	unknown	unknown	gnl\|CDD\|235430
NZ_CP050133.1\|WP_045496558.1\|701064_702438_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	unknown	unknown	gnl\|CDD\|235392
NZ_CP050133.1\|WP_045496584.1\|711313_712048_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	pfam10040_cas6_CAS-III:CAS-IV	gnl\|CDD\|227838
NZ_CP050133.1\|WP_005589634.1\|712158_713067_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656

Protein	Function_ID	Function_description	E-value
NZ_CP050133.1\|WP_045496603.1\|719630_721157_+\|membrane-protein	gnl\|CDD\|274774	TIGR03766, hypothetical_protein_lp_2141, conserved hypothetical integral membrane protein. Models TIGR03110, TIGR03111, and TIGR03112 describe a three-gene system found in several Gram-positive bacteria, where TIGR03110 (XrtG) is distantly related to a putative transpeptidase, exosortase (TIGR02602). This model describes a small clade that correlates by both gene clustering and phyletic pattern, although imperfectly, to the three gene system. Both this narrow clade, and the larger set of full-length homologous integral membrane proteins, have an especially well-conserved region near the C-terminus with an invariant tyrosine. The function is unknown.	1.41867e-130
NZ_CP050133.1\|WP_005589648.1\|718888_719518_+\|orotate-phosphoribosyltransferase	gnl\|CDD\|234771	PRK00455, pyrE, orotate phosphoribosyltransferase; Validated.	1.98352e-76
NZ_CP050133.1\|WP_045496598.1\|717006_717945_+\|dihydroorotate-dehydrogenase	gnl\|CDD\|235982	PRK07259, PRK07259, dihydroorotate dehydrogenase.	1.24496e-177
NZ_CP050133.1\|WP_045496595.1\|716187_716994_+\|dihydroorotate-dehydrogenase-electron-transfer-subunit	gnl\|CDD\|234601	PRK00054, PRK00054, dihydroorotate dehydrogenase electron transfer subunit; Reviewed.	3.53318e-120
NZ_CP050133.1\|WP_045496576.1\|707110_707887_+\|hypothetical-protein	gnl\|CDD\|312974	pfam09659, Cas_Csm6, CRISPR-associated protein (Cas_Csm6). Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	1.35374e-19
NZ_CP050133.1\|WP_045496563.1\|703501_704179_+\|ribose-5-phosphate-isomerase-RpiA	gnl\|CDD\|234816	PRK00702, PRK00702, ribose-5-phosphate isomerase RpiA.	2.26826e-120
NZ_CP050133.1\|WP_166492631.1\|708667_709618_+\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187766	cd09634, Cas1_I-II-III, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.0908e-84
NZ_CP050133.1\|WP_045496579.1\|707879_708611_+\|NAD-dependent-protein-deacylase	gnl\|CDD\|234777	PRK00481, PRK00481, NAD-dependent deacetylase; Provisional.	5.56975e-122
NZ_CP050133.1\|WP_045496569.1\|705429_706242_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|236183	PRK08202, PRK08202, purine nucleoside phosphorylase; Provisional.	2.33342e-164
NZ_CP050133.1\|WP_005589634.1\|712158_713067_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	2.23781e-35
NZ_CP050133.1\|WP_045496572.1\|706400_707108_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	4.57722e-152
NZ_CP050133.1\|WP_052687620.1\|702657_703272_-\|hypothetical-protein	gnl\|CDD\|367814	pfam04103, CD20, CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.	8.49615e-06
NZ_CP050133.1\|WP_045496566.1\|704192_705404_+\|phosphopentomutase	gnl\|CDD\|235430	PRK05362, PRK05362, phosphopentomutase; Provisional.	0
NZ_CP050133.1\|WP_045496558.1\|701064_702438_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	gnl\|CDD\|235392	PRK05291, trmE, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE.	0
NZ_CP050133.1\|WP_045496584.1\|711313_712048_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|227838	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	2.97361e-15
NZ_CP050133.1\|WP_045496601.1\|718148_718841_+\|orotidine-5'-phosphate-decarboxylase	gnl\|CDD\|234695	PRK00230, PRK00230, orotidine-5'-phosphate decarboxylase.	1.22278e-131

>NZ_CP050133.1|WP_166492631.1|708667_709618_+|CRISPR-associated-endonuclease-Cas1
MADLYIQNSSCSLSVREQRVLVRNEEQILLKEISFNLIDNILVFGNAQLSTQLLKAWANRDIFVFYFSSKGEFLFSFDSFRKEDFEKQRSQARASFDSDFCLGIARKIAAAKIGNQLNLLQAFDENDLLDQEDFKRFGDALVNLEQARSIAEIMGIEGRLAKSYFYLLNLLVIDGFHFSGRSRRPALDKFNTLLNFGYSILYSCFMGLIRKNGLSLGFGVMHQPHDHHAVLASDLMEEWRPVIVDDTVLGLINRQEILEEHFIEKEDGIFLTPEGIEIFSRAMRERIFEIHHYVELDKNRYTFLYAADQQILDPEL
>NZ_CP050133.1|WP_045496579.1|707879_708611_+|NAD-dependent-protein-deacylase
MDKIQQLQDMIDQSQHIVFFGGAGVSTESNIPDFRSSDGIYSVKLGRHFTAEQLVSHTMFERYPQEFFDFYKKYLLYPDAKPNAAHAYLAHLEKTGKLKTVVTQNIDSLHEMAGSKNVLKLHGSADRNFCLNCQRFYDLEAFLALSGTVPYCPDCGGVIKPDVTLYEESLDMETFQQAAQAIHQADLLIIGGTSLVVYPAASLIQYFAGKHLVVINKTSIPQDKQADLVIEGKIGEVFAQLRQ
>NZ_CP050133.1|WP_045496576.1|707110_707887_+|hypothetical-protein
MNLDLKEEILFAISRYDYAYAYKLAQQLMSGSPVLTKLLHILAERRELNILPAMDEELKTALQTQSGFQLFCHTDLADEQLANYLYDLEAKLRNEQIIDFVRAVSPAIYRIFMRLIKLEIPDIEHFIHNSRKASYDRWKFERMRESDYAALHDFHAESTVNSSSLTELILHLDLPESVKEEVRQLRELEKSVRNPLAHLIKPFDEAELYRTTGFSSQHFMEILVDLARFTGIVYDREQFYFDEANRLVKALLTGEENG
>NZ_CP050133.1|WP_045496572.1|706400_707108_+|purine-nucleoside-phosphorylase
MSIHIAAKQGEIADKILLPGDPLRAKFIAENFLEDAVCFNEVRNMFGYTGTYKGQRVSVMGTGMGMPSISIYARELIVDYGVKKLIRVGTAGSLNADVHVRELVLAQAAATNSNIIRNDWPHYDFPQIASFDLLDKAYHIAKDLGMTTHVGNVLSSDVFYSNYFEKNIELGKWGVKAVEMEAAALYYLAAQHQVDALAIMTISDSLVNPDEDTTAEERQNTFTDMMKVGLETLID
>NZ_CP050133.1|WP_045496569.1|705429_706242_+|purine-nucleoside-phosphorylase
MATLSEKIKATAAFLKEKGMTEPEFGLILGSGLGELASEIENAVSLDYADIPNWGRSTVVGHAGKLVYGDLAGRKVLALQGRFHFYEGNPLEVVTFPVRVMKALGATGVIVTNAAGGIGYGPGTLMAISDHINMTGQNPLIGENLDEFGPRFPDMSKSYTPEYRVTAHQVADKLGIKLDDGVYIGVTGPTYETPAEIRAYKTLGADAVGMSTVPEVIVAAHSGLKVLGISCITNHAAGFQEELNHEEVVEVTERVKGDFKRLLKAILAEL
>NZ_CP050133.1|WP_045496566.1|704192_705404_+|phosphopentomutase
MSKFNRIHLVVMDSVGIGAAPDANNFVNAGVPDGASDTLGHISKAVGLDVPNMAKLGLGNIEREQALKTVPAEENPSGYYTKLEEVSLGKDTMTGHWEIMGLNITEPFDTFWNGFPEEILTKIEEFSGRKVIREANKPYSGTAVIDDFGPRQMETGELIIYTSADPVLQIAAHEEVIPLDELYRICEFARSITLERPALLGRIIARPYVGEPGNFTRTPNRHDYAVSPFEPTVLDKLNEAGIDTYSVGKINDIFNGAGINHDMGHNQSNNHGVDNLVKAIQSEDFKYGFSFTNLVDFDALYGHRRNPHGYRDCLQEFDARLPEIIENMREDDLLMITADHGNDPTYAGTDHTREYIPLLVFGKSLKGNGHLPVGHFADISATIADNFGVDKAMIGESFLDKLV
>NZ_CP050133.1|WP_045496563.1|703501_704179_+|ribose-5-phosphate-isomerase-RpiA
METLKKLAGIKAAEFVEDGMVVGLGTGSTAYYFVEEIGRRIKEEGLQITAVTTSSVTSKQAEGLGIPLKSIDEVDQVDVTVDGADEVDPQFNGIKGGGGALLMEKVVATPTKDYIWVVDESKLVQKLGAFKLPVEVVQYGAEQVFRRFAEAGYKPSFREKNGQRFITDMQNFIIDLDLGVIENPVEFGRELDHIVGVVEHGLFTKMVNKVIVAGQGGVNILETDN
>NZ_CP050133.1|WP_052687620.1|702657_703272_-|hypothetical-protein
MQQENKVLGILAIVFGAIALLGSWIPIINYLSFFIGTIALILAIIGLIINQKKPKTLAIIGSVISFFSLIIALVTLSFYSRMFNEMGKRFDTLSSTYRSYIDSSEREEEKEKEESTTFTWTKAEFDALKEGDILKRGAGGTKYDDVIRDHGKPTDETTSTVSGSELKTITYLPGGSKYQAVILTFSKNEDGSFLLTSKIGTGLE
>NZ_CP050133.1|WP_045496558.1|701064_702438_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE
MITREFDTIAAISTPLGEGAIGIVRLSGTDSFAIAQKIFRGKDLSKVASHTLNYGHIVDPQNQEILDEVMVGAMRSPKTFTREDIIEINTHGGIAVTNEILQLAIREGARLAEPGEFTKRAFLNGRVDLTQAEAVMDIIRAKTDKAMNNAVKQLDGSLSDLINSTRQEILNTLAQVEVNIDYPEYDDVEEATTEIIREKTLEFEQLLTHLLKTARRGKILREGISTAIIGRPNVGKSSLLNNLLREDKAIVTDIEGTTRDVIEEYVNINGVPLKLIDTAGIRETDDLVEQIGVERSKKALQEADLVLLVLNASEPLTDQDKQLLEISQDSNRIVLLNKTDLEEKIELDQLPTDAIKISVLHNQNIDKIEDRINQLFFENAGIVEQDATYLSNARHISLIEKAVESLQAVNQGLELGMPVDLLQVDLTRTWEILGEITGDAAPDELITQLFSQFCLGK
>NZ_CP050133.1|WP_045496555.1|700877_701063_-|hypothetical-protein
MGITEFIKSKNLGEYLESRKNGQVRERLKERSWLEVLLHKARTTKINPENHQKMKKTKHGS
>NZ_CP050133.1|WP_045496584.1|711313_712048_+|CRISPR-associated-endoribonuclease-Cas6
MKKVELHLSKTRLKDEELISKLQGFLMAQISPDFATFLHEQETNPYSLNLSSRHDESVWVVNLLSEEAEQQMLAPLLNLETIKLESYAEEILVKKVEIHSLSQQNLLDIYQDDDASHLIRVHFYTPTTFKRQGQFVLFPDTRLIFQSLMQKYSRLVEGRAEIEEETLQFLADHSQITSYHLKSHYFPIHGRKYPAFEGRVTIQIKGASTLKAYAQMLLRFGEYAGVGTKCSLGMGGMRIEERKG
>NZ_CP050133.1|WP_005589634.1|712158_713067_-|LysR-family-transcriptional-regulator
MRIQQLHYIIKIVETGSMNEAAKQLFITQPSLSNAVRDLENEMGIEIFIRNPKGITLTKDGMEFLSYARQVVEQTQLLEERYKNPVAHRELFSVSAQHYAFVVNAFVSLLKKSDMEKYELFLRETRTWEIIDDVKNFRSEIGVLFLNSYNRDVLSKMLDDSHLIATHLFTAQPHIFVSKSNPLAKKKLVQLSDLEDFPYLSYDQGTHNSFYFSEEILSQEHHKKSIVVSDRATLFNLLIGLDGYTIATGILNSNLNGDNIVSIPLDIDDPIELVYIQHEKASLSKMGERFIEYLIEEVQFDK
>NZ_CP050133.1|WP_045496587.1|713177_713993_+|hypothetical-protein
MAKEDDYKNRSVGLPITIFIVFLTICLMIPLGKVMIMWGLKSAYEGLGRSSVSSTVRQKSSEELRLEEKVLERGNHRFTWTTDDIINLQIKDTTAGQNGASLDQILEKHGKASSFFYTESNENIELNYTSEITQGHHSSLRLTFEKDGSGYHLIGKSANILDEAYPRLPQGDSPHLWTKDDIAGLQVRDESTGNLGMSYDEIIQLFGLPRESEVVISHLDVADSQHIGLELKYLTSDERYNNEWVHLIFHRQEDGVFRLTTVTSHIDRRER
>NZ_CP050133.1|WP_045496590.1|714138_714984_+|hypothetical-protein
MKRQEDSFEDIAFELEKETHKSKFLPFMVVAIVVFSLIGTVFLTLSLSEKSKAKQTPTPSSQISSSSNSLEDEKAEAEQFAKSLIVSPEKSGPFLWTVEKAVALPMNKYKGGAVLEDVLKEFGKPVQGGAWIDFLPNHKVQKHIRLVWESKNGSTGYVSLTFAEFDGVYKVISKYHFSLSSDKIQVDNNPKRSFLWTQAYIDSLVIGAREGTAKGTPYDEIVLKVGLPLYQTISGDDNQLKMRVDYVNPHSWQNPEQLKRVHLEFYKQGDGRWRLVSKESE
>NZ_CP050133.1|WP_045496592.1|715011_715977_+|hypothetical-protein
MRRSSKKKRDLHSFREIKRDLYRQQKLKREELSTMTMQEERKRISLAFTLLCVAISFALFFGFYYLSQQVPNKAELKYKYDDKSSSVSGDSSASQQNDDESKLTQEQKELKKKIVEEDEEKFAFNWTLDNFVELKVENGGTNSPTLEEVIAKYGKGSNVSFTENGLTLTYKTRIVDVPRYGSSGHPQEINLVFYDPDSNGKNYYLISKSAVYLDDSNYPSATKDEFVFKWKPEDMDTLKIGDSQHGKGGMTYQEVVGRFGLPSELNIYGSGMSDSPLSLRANYRNFRNLERKYDSVTLIFKRQEDGSFYLANANSEFDKSW
>NZ_CP050133.1|WP_045496595.1|716187_716994_+|dihydroorotate-dehydrogenase-electron-transfer-subunit
MVSDSCKKRFGKIMLEQMELLEQVEIAPQIFSMRLKGQMVSQMQVGQFLHIRVPDDSKLLRRPISISEIDREQGICRIIYRVEGGGTAIFSQLPVGSYLDVMGPQGNGFDLSPVEKGDKVLIIGGGIGVPPLLQTAKELHAKGAQVTAVLGFANQSAVILEEEFRECSQLFITTDDGTYGQKGYVSTIVDELTEEFAAVYSCGAPGMLQYVDRKFHDHPHAYLSMESRMACGMGACYACVVHVAGQDEAVNKRVCEDGPVFETGTIVL
>NZ_CP050133.1|WP_045496598.1|717006_717945_+|dihydroorotate-dehydrogenase
MTENRLKISLPGLELKNPIIPASGCFGFGQEYAKYYDLDLLGSIMIKATTQNPRFGNPTPRVAETPAGMLNAIGLQNPGVDAVLAEKLPWLAQHYPDLPVIANVAGFSNEEYAYVSGKISQAPNVKAIELNISCPNVDHGNAGLLIGQVPELAYEAVKAAVAASQVPVYVKLTPSVADITQVAKAAEDAGASGLTMINTLVGMRFDLKTKRPIIANGTGGMSGPAVFPVALKLIHQVAQFTKLPIIGMGGVDSAEAALEMFIAGASAIGVGTANFTDPYACPNIIEKLPQVMDKYGIESLESLRKEVRENLL
>NZ_CP050133.1|WP_045496601.1|718148_718841_+|orotidine-5'-phosphate-decarboxylase
MREERPIIALDFPSFDDVKNFLEHFPEDEKLYVKIGMEFFYAIGPEIVHYLKGLGHSIFLDLKLHDIPNTVRSAMSVLGTFGVDMVTVHAAGGVEMMQEAKKVLGDNAKLVAVTQLTSTSEEDMRDCQNIQTTVQESVVNYARKAKEAGLDGVVCSALEVELIKAATADDFLCVTPGIRPAGAEIGDQKRVMTPQEAHQIGSNYIVVGRPIIQAENPWDAYHEIKKQWNS
>NZ_CP050133.1|WP_005589648.1|718888_719518_+|orotate-phosphoribosyltransferase
MTLANDIARDLLKIKAVYLKPEEPFTWASGIKSPIYTDNRVTLAYPETRTLIENGFVEKIRAEFPDVEVIAGTATAGIPHGAIIADKMNLPFAYIRSKPKDHGAGNQIEGRVAPGQKMVVIEDLISTGGSVLDAIAAAKREGADVIGAAAIFTYELPKADKNFADAGVKLVTLSNYTELIHLAEQEGYINAEGLTLLKKFKDDQENWQN
>NZ_CP050133.1|WP_045496603.1|719630_721157_+|membrane-protein
MSKIYHITFLILQKIMLVLSLHWLFTAIFHVSQLSSLALILFGVLAILANRYRFQLKKFYHFLMRHKLAIALAALLFQLIMLLSAELLIRRDAAVVFTGAFKYLKESSISSYLTRNPNNLPLFLYERFFFNLFGDAALWIMQGLNLFYVNIASWILYKGCQRYFSQATSDAVFSLYVALVGFSPYYMSMYTDIPPLPLISLQIFLALSLLENKDDSRQIIARSLLLGILTSLAFLIRPTVMILLIAVFGVLFLRQNWKKFFLTAAVFALSFSAGYLPLHYGLAHQTEVPIIQGQGLAKGPLLFINLGLTNIGHDQEDMKEGLLQYVEPDKRADYNNGMFARENVIKEIKRRLKEYTPLTFLQHLYYKHSLTVAEGNLGWLYRSVENEKTPYISPLYEFTKDNAFAQFIRDFFLNSDKNSFRFYSLLKQAVWIIMALGLVFALWKYRPNDSLNFLILAVFGGLLFLQIFEGGKTRYLIQFLPQILILSAVGLTQYPLDLTRMKFWEKKV

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Crispr_ID: NZ_CP050133_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050133_4

816872-817696

Unclear

Consensus_repeat	Method
GTTATACCTTACCTATAAGGAATTGAGAC	PILER-CR
GTTATACCTTACCTATAAGGAATTGAGAC	CRISPRCasFinder
GTTATACCTTACCTATAAGGAATTGAGAC	CRT

11 spacers

cas1,cas6

The CRISPR arrays of NZ_CP050133_4

>merge|NZ_CP050133|4|816872-817696|PILER-CR,CRISPRCasFinder,CRT
GTTATACCTTACCTATAAGGAATTGAGACTAGTAAAACACCACCTTTTTAATAATACTTGTCTAATAAGACAGTTATACCTTACCTATAAGGAATTGAGACAAATTACTATAGCCATTATAATCACCTTCTTTCTATGTTTTGGCTATGTTATACCTTACCTATAAGGAATTGAGACGAAAAGTACTGGCATATTAGCCACCTTCTTTCTTAATTTGTTATACCTTACCTATAAGGAATTGAGACAGATTCCAAGGCGCAATATGGTAGATAGGTAAACCTTCTACCGTTATACCTTACCTATAAGGAATTGAGACGTAAAATTGGTATAAAAGTCGCAGTAAAAGACCCTCATACCGTTATACCTTACCTATAAGGAATTGAGACTTAAATTCGTGCGTTCTCTCCTCATGATAGGTATGCAAGTTACTGTTATACCTTACCTATAAGGAATTGAGACAATATTGAATATATCGGTTTATTAGTTTGTACAATTAATACTCTAAGTTATGCCTTACCTATAAGGAATTGAGACATTTTTTCAATTTTATACCGATAATCATCTTCTAGGTAAGCTACAAGGTTATACCTTACCTATAAGGAATTGAGACGAAATTCCAGTTGGTTTTTCACCATTTAAAATTTCGAAAGTTATACCTTACCTATAAGGAATTGAGACTCATATATTGACCTCATTTCTAAAAGAACTATTTATAAAAAATATGTTATACCTTACCTATAAGGAATTGGGACTTGAGTACGTTCATCAAAAATCCGCCAGAATTTTTCAAAATTTCGTTATACCTTACCTATAAGGAATTGTTTG

>NZ_CP050133|4|1|816872-817623|PILER-CR
GTTATACCTTACCTATAAGGAATTGAGAC	TAGTAAAACACCACCTTTTTAATAATACTTGTCTAATAAGACA
GTTATACCTTACCTATAAGGAATTGAGAC	AAATTACTATAGCCATTATAATCACCTTCTTTCTATGTTTTGGCTAT
GTTATACCTTACCTATAAGGAATTGAGAC	GAAAAGTACTGGCATATTAGCCACCTTCTTTCTTAATTT
GTTATACCTTACCTATAAGGAATTGAGAC	AGATTCCAAGGCGCAATATGGTAGATAGGTAAACCTTCTACC
GTTATACCTTACCTATAAGGAATTGAGAC	GTAAAATTGGTATAAAAGTCGCAGTAAAAGACCCTCATACC
GTTATACCTTACCTATAAGGAATTGAGAC	TTAAATTCGTGCGTTCTCTCCTCATGATAGGTATGCAAGTTACT
GTTATACCTTACCTATAAGGAATTGAGAC	AATATTGAATATATCGGTTTATTAGTTTGTACAATTAATACTCTAA
GTTATGCCTTACCTATAAGGAATTGAGAC	ATTTTTTCAATTTTATACCGATAATCATCTTCTAGGTAAGCTACAAG
GTTATACCTTACCTATAAGGAATTGAGAC	GAAATTCCAGTTGGTTTTTCACCATTTAAAATTTCGAAA
GTTATACCTTACCTATAAGGAATTGAGAC	TCATATATTGACCTCATTTCTAAAAGAACTATTTATAAAAAATAT
GTTATACCTTACCTATAAGGAATTGGGAC

>NZ_CP050133|4|4|816872-817696|CRISPRCasFinder
GTTATACCTTACCTATAAGGAATTGAGAC	TAGTAAAACACCACCTTTTTAATAATACTTGTCTAATAAGACA
GTTATACCTTACCTATAAGGAATTGAGAC	AAATTACTATAGCCATTATAATCACCTTCTTTCTATGTTTTGGCTAT
GTTATACCTTACCTATAAGGAATTGAGAC	GAAAAGTACTGGCATATTAGCCACCTTCTTTCTTAATTT
GTTATACCTTACCTATAAGGAATTGAGAC	AGATTCCAAGGCGCAATATGGTAGATAGGTAAACCTTCTACC
GTTATACCTTACCTATAAGGAATTGAGAC	GTAAAATTGGTATAAAAGTCGCAGTAAAAGACCCTCATACC
GTTATACCTTACCTATAAGGAATTGAGAC	TTAAATTCGTGCGTTCTCTCCTCATGATAGGTATGCAAGTTACT
GTTATACCTTACCTATAAGGAATTGAGAC	AATATTGAATATATCGGTTTATTAGTTTGTACAATTAATACTCTAA
GTTATGCCTTACCTATAAGGAATTGAGAC	ATTTTTTCAATTTTATACCGATAATCATCTTCTAGGTAAGCTACAAG
GTTATACCTTACCTATAAGGAATTGAGAC	GAAATTCCAGTTGGTTTTTCACCATTTAAAATTTCGAAA
GTTATACCTTACCTATAAGGAATTGAGAC	TCATATATTGACCTCATTTCTAAAAGAACTATTTATAAAAAATAT
GTTATACCTTACCTATAAGGAATTGGGAC	TTGAGTACGTTCATCAAAAATCCGCCAGAATTTTTCAAAATTTC
GTTATACCTTACCTATAAGGAATTGTTTG

>NZ_CP050133|4|2|816872-817696|CRT
GTTATACCTTACCTATAAGGAATTGAGAC	TAGTAAAACACCACCTTTTTAATAATACTTGTCTAATAAGACA
GTTATACCTTACCTATAAGGAATTGAGAC	AAATTACTATAGCCATTATAATCACCTTCTTTCTATGTTTTGGCTAT
GTTATACCTTACCTATAAGGAATTGAGAC	GAAAAGTACTGGCATATTAGCCACCTTCTTTCTTAATTT
GTTATACCTTACCTATAAGGAATTGAGAC	AGATTCCAAGGCGCAATATGGTAGATAGGTAAACCTTCTACC
GTTATACCTTACCTATAAGGAATTGAGAC	GTAAAATTGGTATAAAAGTCGCAGTAAAAGACCCTCATACC
GTTATACCTTACCTATAAGGAATTGAGAC	TTAAATTCGTGCGTTCTCTCCTCATGATAGGTATGCAAGTTACT
GTTATACCTTACCTATAAGGAATTGAGAC	AATATTGAATATATCGGTTTATTAGTTTGTACAATTAATACTCTAA
GTTATGCCTTACCTATAAGGAATTGAGAC	ATTTTTTCAATTTTATACCGATAATCATCTTCTAGGTAAGCTACAAG
GTTATACCTTACCTATAAGGAATTGAGAC	GAAATTCCAGTTGGTTTTTCACCATTTAAAATTTCGAAA
GTTATACCTTACCTATAAGGAATTGAGAC	TCATATATTGACCTCATTTCTAAAAGAACTATTTATAAAAAATAT
GTTATACCTTACCTATAAGGAATTGGGAC	TTGAGTACGTTCATCAAAAATCCGCCAGAATTTTTCAAAATTTC
GTTATACCTTACCTATAAGGAATTGTTTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050133.1\|WP_001287273.1\|813876_814377_+\|50S-ribosomal-protein-L10	unknown	unknown	gnl\|CDD\|234632
NZ_CP050133.1\|WP_045496825.1\|811312_812260_+\|homocysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|181899
NZ_CP050133.1\|WP_045496823.1\|810468_811176_+\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|236304
NZ_CP050133.1\|WP_045496853.1\|827778_828477_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP050133.1\|WP_080940856.1\|816203_816338_+\|hypothetical-protein	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|376633
NZ_CP050133.1\|WP_045496846.1\|821532_822216_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225917
NZ_CP050133.1\|WP_045497698.1\|823516_824848_+\|branched-chain-amino-acid-transport-system-II-carrier-protein	unknown	unknown	gnl\|CDD\|283235
NZ_CP050133.1\|WP_045496856.1\|828473_829508_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP050133.1\|WP_166492632.1\|815135_815864_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NZ_CP050133.1\|WP_052687617.1\|816365_816707_+\|hypothetical-protein	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
NZ_CP050133.1\|WP_005589795.1\|830389_830710_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050133.1\|WP_160290160.1\|815941_816100_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050133.1\|WP_005589794.1\|829651_830362_+\|thiol-disulfide-oxidoreductase-associated-membrane-protein-CcdA2	unknown	unknown	gnl\|CDD\|280792
NZ_CP050133.1\|WP_001196964.1\|814450_814819_+\|50S-ribosomal-protein-L7/L12	unknown	unknown	gnl\|CDD\|234671
NZ_CP050133.1\|WP_045496841.1\|817922_819659_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP050133.1\|WP_015604705.1\|813301_813643_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050133.1\|WP_045496844.1\|819668_821441_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP050133.1\|WP_045496848.1\|822272_823286_-\|YdcF-family-protein	unknown	unknown	gnl\|CDD\|99750
NZ_CP050133.1\|WP_166492633.1\|825085_827698_+\|YSIRK-type-signal-peptide-containing-protein	unknown	unknown	gnl\|CDD\|338196
NZ_CP050133.1\|WP_045496828.1\|812375_813173_+\|formate/nitrite-transporter	unknown	unknown	gnl\|CDD\|225027

Protein	Function_ID	Function_description	E-value
NZ_CP050133.1\|WP_001287273.1\|813876_814377_+\|50S-ribosomal-protein-L10	gnl\|CDD\|234632	PRK00099, rplJ, 50S ribosomal protein L10; Reviewed.	8.84513e-61
NZ_CP050133.1\|WP_045496825.1\|811312_812260_+\|homocysteine-S-methyltransferase	gnl\|CDD\|181899	PRK09485, mmuM, homocysteine methyltransferase; Provisional.	3.65836e-162
NZ_CP050133.1\|WP_045496823.1\|810468_811176_+\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|236304	PRK08581, PRK08581, amidase domain-containing protein.	7.36532e-59
NZ_CP050133.1\|WP_045496853.1\|827778_828477_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	6.35976e-71
NZ_CP050133.1\|WP_080940856.1\|816203_816338_+\|hypothetical-protein	gnl\|CDD\|376633	pfam01867, Cas_Cas1, CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.	4.62361e-15
NZ_CP050133.1\|WP_045496846.1\|821532_822216_-\|hypothetical-protein	gnl\|CDD\|225917	COG3382, COG3382, Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only].	1.18639e-31
NZ_CP050133.1\|WP_045497698.1\|823516_824848_+\|branched-chain-amino-acid-transport-system-II-carrier-protein	gnl\|CDD\|283235	pfam05525, Branch_AA_trans, Branched-chain amino acid transport protein. This family consists of several bacterial branched-chain amino acid transport proteins which are responsible for the transport of leucine, isoleucine and valine via proton motive force.	4.12767e-142
NZ_CP050133.1\|WP_045496856.1\|828473_829508_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.13456e-47
NZ_CP050133.1\|WP_166492632.1\|815135_815864_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	5.34386e-41
NZ_CP050133.1\|WP_052687617.1\|816365_816707_+\|hypothetical-protein	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	5.04796e-18
NZ_CP050133.1\|WP_005589794.1\|829651_830362_+\|thiol-disulfide-oxidoreductase-associated-membrane-protein-CcdA2	gnl\|CDD\|280792	pfam02683, DsbD, Cytochrome C biogenesis protein transmembrane region. This family consists of the transmembrane (i.e. non-catalytic) region of Cytochrome C biogenesis proteins also known as disulphide interchange proteins. These proteins posses a protein disulphide isomerase like domain that is not found within the aligned region of this family.	5.1938e-44
NZ_CP050133.1\|WP_001196964.1\|814450_814819_+\|50S-ribosomal-protein-L7/L12	gnl\|CDD\|234671	PRK00157, rplL, 50S ribosomal protein L7/L12; Reviewed.	6.90311e-46
NZ_CP050133.1\|WP_045496841.1\|817922_819659_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	7.86238e-162
NZ_CP050133.1\|WP_045496844.1\|819668_821441_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.81556e-177
NZ_CP050133.1\|WP_045496848.1\|822272_823286_-\|YdcF-family-protein	gnl\|CDD\|99750	cd06259, YdcF-like, YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been idenitified. The family also includes Escherichia coli sanA and Salmonella typhimurium sfiX, which are involved in vancomycin resistance; sfiX may also be involved in murein synthesis.	2.91767e-45
NZ_CP050133.1\|WP_166492633.1\|825085_827698_+\|YSIRK-type-signal-peptide-containing-protein	gnl\|CDD\|338196	pfam11966, SSURE, Fibronectin-binding repeat. Streptococcal surface repeat domain - SSURE - is a protein fragment found to bind to extracellular matrix protein fibronectin but not to collagen or submaxillary mucin in Streptococci. Anti-SSURE antibodies recognized the corresponding protein on the surface of streptococcal cells. The full-length proteins are thus fibronectin-binding surface adhesins.	4.85744e-39
NZ_CP050133.1\|WP_045496828.1\|812375_813173_+\|formate/nitrite-transporter	gnl\|CDD\|225027	COG2116, FocA, Formate/nitrite family of transporters [Inorganic ion transport and metabolism].	2.07399e-60

>NZ_CP050133.1|WP_052687617.1|816365_816707_+|hypothetical-protein
MLHASNNRPYSLHLDFADYMKPVIVDRVILSLINKHQINATDHFEEREDGSVYLNREGKYIVLRSFEEKLQTRLVMGGSTYTYAQLIQHDIRQFKRILQQDGNLKRFKPYKYY
>NZ_CP050133.1|WP_080940856.1|816203_816338_+|hypothetical-protein
MFNEILNQSGFSFVKRTKRPPRDPLNALISFCNTILYSRVLRLI
>NZ_CP050133.1|WP_160290160.1|815941_816100_+|hypothetical-protein
MTRRTNLACSFSESKVYWVLDEENFKPEKRLKTYTMDFIAQNPRLVSKTIEP
>NZ_CP050133.1|WP_166492632.1|815135_815864_+|CRISPR-associated-endoribonuclease-Cas6
MQLLIELQKIDQFILPVNYNYLLQSMIYNLLKNKEDLSAQLHERGYLLEDKYFKLFTFSLLQGQYKMQGKRIEFLDKVRFEIRTIDQSILFTIAEALSNLDELRIGRNLVKILNVKIGEKKLTGTSYKIRMISPLVVRSTDADTKKTLYYNPFDMEFHSRIMENFARKYQAYYHKVPTGKFDIEPINFSLKNKFVTKYKDFLITGWKGEFEIRGDAEVLDFLYQVGLGEKNSMGFGMFVIEE
>NZ_CP050133.1|WP_001196964.1|814450_814819_+|50S-ribosomal-protein-L7/L12
MALNIENIIAEIKEASILELNDLVKAIEEEFGVTAAAPVAVAAAGAADAGAAKDSFDVELTAAGDKKVGVIKVVREITGLGLKEAKELVDGAPGVIKEGVPTAEAEEIKAKLEEAGASVTLK
>NZ_CP050133.1|WP_001287273.1|813876_814377_+|50S-ribosomal-protein-L10
MSEAIIAKKAELVDVVAEKMKAAASIVVVDARGLTVEQDTVLRRELRGSEVEYKVIKNSILRRAAEKAGLEDLASVFVGPSAVAFSNEDVIAPAKILNDFAKNAEALEIKGGAIEGAVASKEEILALATLPNREGLLSMLLSVLQAPVRNVALAVKAVADNKEDAA
>NZ_CP050133.1|WP_015604705.1|813301_813643_+|hypothetical-protein
MNKLTIQAPDGSNVKTLSPMYSITTLLFNFFVPLFRKDWKYFGIMLGSLFVFAVIATLLIPDDFLRPVGTAYNLFWAFFYNRLWIKDRVFTDGWVPADDASKALLDKTFPKNA
>NZ_CP050133.1|WP_045496828.1|812375_813173_+|formate/nitrite-transporter
MVESTFIPKIEAACRKKEGLFDTNKGKYAVRSIFAGAFLTFSTGAGAIAADLTNKIVPGTGRFLFPFIFAWGLAYIVFLNAELVTSNMMFLTAGTFLKKIDWKKALIILFYCTFFNLIGALIAGWLFANSAAYAGLSKESFIAGVVQMKLARSNELILLEGILANVFVNIAILSFVLVKDSTAKLFLVISAIYMFVFLTNEHLAANFASFAIVKFSSAASQVANFGIGNILRHWAVTFVGNLIGGGLLIGLPYAWFNKKEEHYVD
>NZ_CP050133.1|WP_045496825.1|811312_812260_+|homocysteine-S-methyltransferase
MGAFKDLLEKQDIIILDGALGTELERQGYDVSGRLWSAKYLLENPQIIQGLHEDYVRAGSDIITTSSYQANIPAFVEEGLSLDKAYELFKETVFLAQAAIKNVWQGLSLDEQKKRSYPLIAGSVGPYAAYLADGSEYTGAYHLSEEEFKDFHRPRIQALLDAGCDLLALETIPNGAETKALVHLLSEAFPQVEAYLSFTAQTVSAISDGTLIEEVGRLAQSSPQVLAVGFNCTAPHLIAPLLEKLKQVCDKPLLSYPNSGEIYNVATNTWQDNPEQQLCLTDYSHLWKKQGVQLFGGCCRTRPEDIRRLAGELRT
>NZ_CP050133.1|WP_045496823.1|810468_811176_+|N-acetylmuramoyl-L-alanine-amidase
MKKRISKERKKLLTGLTGLAVMASTVVFGLALSKQIKPASANDAVQQPLNQTEYFISQISEPARQLAQDNDLYASVMIAQAILESGSGQSGLSGYPHYNLFGIKGAYAGQSATMETLEEDGQGNTYAINDQFRSYSSYAESLQDYVYVLRQSHFAGAWKSNAPTYQDATAALTGVYATDSHYYAKLNYLIEAYNLTQFDSPSYQTGASNMVYNPYRGQYTTQDVLETDQAWASHN
>NZ_CP050133.1|WP_045496841.1|817922_819659_+|ABC-transporter-ATP-binding-protein
MLYIWSYLKRYPKWLVLDFVSAIFFVVVNLGLPTVLARMIDEGINQGNQERLYFWGFIMLLVIILGILGRIVLSYAAGKLTTSMVRDMRNDLYDKLQEYSHHEYEQIGVSSLVTRITSDAFVLMQFAEQTLKMGAITPIMMLSSILMIFLTSPSMAWIVAISVPFLAIVVWYVAVKTRPLSEKQQKTLDKINQYARENLTGLRVIRAFAREEFLEERFANENEIYAENSNRLFKLTGLTEPLFVQIIIAMIVAIVWFALKPLGSGELKIGDLVAFIEYSFHALLSFLLLSSLFTMYPRTAVSSERLKEVMDMPISIDPNENGITETATRGYLEFDNVTFAYPGETENPVLHNISFKAKPGETIAFIGSTGSGKSSLVQLIPRFYDVTLGKILVDGVDVRAYNLKALRQKIGFIPQKALLFTGTIAENIRYGKEDASSEELNQAADVAQARDFIESREERFETHLAEGGSNLSGGQKQRLSIARAVVKEPDIYIFDDSFSALDYKTDATLRRRLKEVTQDATVLIVAQRVGTIMDADQIIVLDKGEIVGRGRHEELMENNAIYREIANSQLNSQSLTEE
>NZ_CP050133.1|WP_045496844.1|819668_821441_+|ABC-transporter-ATP-binding-protein
MKENSFVRLWGYLKVYKAAVLLAVFLKIVSVVMSVLEPFVLGLAITELTQNLLDMAKGVPGAAINSSYVAWIMLLYFIRALFYEIGAYFSNYFMTNAVQSTVRDMRNELSRKINRIPVSYFDKHQFGDLIGRFTSDVETVSNALQQSFLQVVNAVMTLILVIGMVLYLNIQLALIVIVSIPLTYLGARFILKKSQPYFKQQADVLGAMNGFVQENLSGFNVLKLYGREETSAEDFRAITQNLQEVGFKASFISGLMMPVLNGISDLTYLIVALVGGLQVIAGQLTIGNMQAFVQYVWQVNQPIQNLTQLAGQLQSAKSSLDRIFQILDEPDEVMDNTVRLDKDLTGQVSFKDVDFQYVADKPLIRNFNLEVQPGEMVAIVGPTGAGKTTLINLLMRFYDVTKGSISVDGHDIRQLSRQDYRKQFGMVLQDAWLYEGTIKENLRFGNLDATDEEIVEAAKSANVDHFIRTLPGGYNMEMNQESSNISLGQKQLLTIARALLADPKILILDEATSSVDTRLELLIQKAMKTLMQGRTSFVIAHRLSTIQEADKILVLKDGQIIEQGNHESLLADKGFYHDLYMSQFSDKKED
>NZ_CP050133.1|WP_045496846.1|821532_822216_-|hypothetical-protein
MKFTIDKSLAELGITSVVLGIARNVDPQAPLSEDFLQKQKEAENWALNCNLAEITDHPTIQGYCDLLQKVGRSVKKNPPTVPALIRNIQHRGSIPRINSVIDIYNVESLHSLLAIGGHDLDKIGDEIEFTVSQKDDIFLPILSKEKHVAPTDYVYRDEKGILAWLDVRDSDLYKFDNSTKNAIFIIQGNAHTSIQMRLEALERIHQDLAAAMPNLEFETHVIQVDDL
>NZ_CP050133.1|WP_045496848.1|822272_823286_-|YdcF-family-protein
MLLHLIWLIPAAIFTFLFYREPGSLFNAYLLTFTLVMMGIVLAGLTIVSLERFIGYTPAMISFYILLLAIPISIFASTAYLIFNGRQMLQLEGLRLANLLSLLYGLAIVGIGLLHFLAPRSFLAILISLADLLLFYGTFLYLSYIIYAFFLNIFPVKKEPQTIIILGAGLFGDKVPPLLAQRLDKGRAIYEKFNQKPVIIVSGGQGDDEWISEAEAMAGYLMEKGVPADSIFLENKSRTTLENLIFSKELMLAHGLEQDRVLLVTNSFHALRAGIYMRQVGLKGRSIGSRTAFYFLPSAWIRETAGLIRIYWKWHAFIIGILLLPFLFSLFHAYFSL
>NZ_CP050133.1|WP_045497698.1|823516_824848_+|branched-chain-amino-acid-transport-system-II-carrier-protein
MIKKGSLTGLLLFGMFFGAGNLIFPPQLGLESGQNFWPAIGGFVLSGVGIAILTLIIGTLNPKGYIDEISKKIAPWFAVVYLVALYLAIGPFFAIPRTATTAFSVGIEPMLPAGSHAIWLFGFTLVYFAFAYLIALNPSKILDSIGRYLTPIFALLIVVLVVLGAAKYGSTAPQGATAEYAASAFGAGFLQGYNTLDALASVAFSVVAVTTLNQLGFKNKKEYISTIWVVGILVALGFSVLYIGLAFLGNHFPLNLANLPKGANVGASVLSSATQAIFGPMAQVFLAIMVTVTCFTTTAGLIVSTGEFFHNTFPKVSYKVYATIFTLVGFAIANLGLNAIIQYSVPALEILYPITITIVMIVMVNRFLPLSKPGMQLTIAVVTLIAFASILGRQFKLTAILNLVNALPFAQASLPWLLPALVGILLSLLLPNKQISDAFEFEA
>NZ_CP050133.1|WP_166492633.1|825085_827698_+|YSIRK-type-signal-peptide-containing-protein
MKFNLNQKYARWSIRRLSVGVASVVVASGFFLLVGQPNTVHADVLTTTPTEVLQTDSSSLEKNELPETVLKEGVDSNLPENQSASKEVADETISLDKSSLTPKEEVTKTKEEQNITEVTDQKEETKPVATLDVVSNQAREAAISQSVTTQDEVKKGVEENTKDSVDVPASYLEKANVPGPFLAGVNQVIPYEAFGGDGMLTRLLLKSSDKAPWSDNGTANNPALLPLEGLAKGQYFYEVDLNGNTTGKDGQALLDQLRTNGTYAYQATVKVYGAKDGKADLTNLVATKNVTVSLNGLISKEAVKDSVTKNIKDHIDVPASYLEKANVPGPFLAGVNQVIPYEAFGGDGMLTRLLLKSSDKAPWSDNGTAKNPALLPLEGLAKGQYFYEVDLNGNTTGKDGQALLDQLRANGTHSYQATVKVYGAKDGKADLTNLVATKNVTVSLNGLISKEAVKDSVTKNIKDHIDVPASYLEKANVPGPFLAGVNQVIPYEAFGGDGMLTRLLLKSSDKAPWSDNGTAKNPALLPLEGLAKGQYFYEVDLNGNTTGKDGQALLDQLRANGTHSYQATVKVYGAKDGKADLTNLVATKNVTVNLNGLVSKEAVKDSVTKNIKDHIDVPASYLEKANVPGPFLAGVNQVIPYEAFGGDGMLTRLLLKSSDKAPWSDNGSANNPALLPLEGLAKGQYFYEVDLNGNTTGKDGQALLDQLRTNGTHTYQATVKVYGAKDGKPDLTNLIATRQVTIQLRGKEMATIPSQEGQMNMKPSTTPSQEGQMNMKPSTTPSQEGQMNKKPSATDSMSTAEGTKEVDHRMTDVKGQHPTSKPMADTMKKNDKATLPTTGEAQTATATIGFLGLALAGILSLLGLKEKQKD
>NZ_CP050133.1|WP_045496853.1|827778_828477_+|response-regulator-transcription-factor
MGKTILLVDDEMDILDIQKRYLMQDGYHVLVARDGVEGLDLFRKKSVDLIITDIMMPNMDGYEFISEVQYIAPDQPFLFTTAKTSDQDKIYGLSLGADDFIAKPFSPRELVLRVNNILRRLHRGGEIEQIELGDLVMNHAVHEARIGEHFLELTVKSFELLWILASNPERVFSKTELYEKVWQEDFVDDTNTLNVHIHALRQELTRYASSDTPAVKTVWGLGYKMEGARGIK
>NZ_CP050133.1|WP_045496856.1|828473_829508_+|HAMP-domain-containing-histidine-kinase
MKLKSYILVGYLISSLLTILLVFWAVQRMLIVKSEIYFLVGMTLIASFIGAAVSLFLLSPVFSSLRHLKKQAQNIADKDFSTEIDAKGPIEFQELGQAFNDMSHNLQETFESLDESEREKGMMIAQLSHDIKTPITSIQSTVEGILDGVIEEEEQIHYLTTISRQTERLNKLVEELDVLTLNAQPRIESDGEAEIVFLDQLLIEVMSEFQLLIEQEERDIYIQVSPESAKIKSHYDKLSRILVNLLNNAFKYSDPGTKIEVVAQLTEPILTISVKDEGQGIAPEDLDKIFKRLYRVETSRNMKTGGHGLGLAIARELAHQLGGEITVESQCGLGSTFTFALNLT
>NZ_CP050133.1|WP_005589794.1|829651_830362_+|thiol-disulfide-oxidoreductase-associated-membrane-protein-CcdA2
MATSFLFFISVFLAGILSFFSPCILPLMPVYVGILLDSDQPKTVRFMGKDISLYGLAKTLCFIAGLSTVFLVLGYGAGALGQVLYAPWFRYVLGGIVILLGIHQMGIINIQQLQKQKSIQLKKNSKRSDFLNAFLLGITFSFGWTPCVGPVLSSVLAIAASGGNGALQGGLLMLVYTLGLALPFLAMALASGWVLQRFAKLKPHMGTLKKIGGALIILMGILLMLGNLNALASLFG
>NZ_CP050133.1|WP_005589795.1|830389_830710_+|hypothetical-protein
MKKIATLTMATLSIFALAACSSQKSNSDMKKMDDSSMMKKEDMKKDDMKKEDMKDSSMSDDKMKKDDMKDSSMISESKSDMKDDMKSSDSSMKDDMKDSSEMSSEK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP050133_3	3.5\|710589\|34\|NZ_CP050133\|CRT	710589-710622	34	MK448735	Streptococcus phage Javan349, complete genome	17702-17735	0	1.0
NZ_CP050133_3	3.4\|710517\|35\|NZ_CP050133\|CRT	710517-710551	35	MN693666	Marine virus AFVG_250M158, complete genome	7591-7625	7	0.8
NZ_CP050133_3	3.16\|710589\|46\|NZ_CP050133\|CRISPRCasFinder	710589-710634	46	MK448735	Streptococcus phage Javan349, complete genome	17690-17735	8	0.826
NZ_CP050133_3	3.3\|710445\|35\|NZ_CP050133\|CRT	710445-710479	35	NZ_MK134375	Acinetobacter baumannii strain 34AB plasmid p34AB, complete sequence	704-738	9	0.743
NZ_CP050133_3	3.3\|710445\|35\|NZ_CP050133\|CRT	710445-710479	35	NZ_CP038010	Acinetobacter haemolyticus strain TJR01 plasmid pAHTJR1, complete sequence	109397-109431	9	0.743
NZ_CP050133_3	3.3\|710445\|35\|NZ_CP050133\|CRT	710445-710479	35	NZ_CP043053	Acinetobacter pittii strain AP43 plasmid pAP43-OXA58-NDM1, complete sequence	56466-56500	9	0.743
NZ_CP050133_3	3.3\|710445\|35\|NZ_CP050133\|CRT	710445-710479	35	NZ_CP033130	Acinetobacter wuhouensis strain WCHAW010062 plasmid pOXA23_010062, complete sequence	61775-61809	9	0.743
NZ_CP050133_3	3.3\|710445\|35\|NZ_CP050133\|CRT	710445-710479	35	NZ_CP029396	Acinetobacter defluvii strain WCHA30 plasmid pOXA58_010030, complete sequence	119181-119215	9	0.743
NZ_CP050133_3	3.3\|710445\|35\|NZ_CP050133\|CRT	710445-710479	35	NZ_CP048828	Acinetobacter baumannii strain ABF9692 plasmid pABF9692, complete sequence	242470-242504	9	0.743

1. spacer 3.5|710589|34|NZ_CP050133|CRT matches to MK448735 (Streptococcus phage Javan349, complete genome) position: , mismatch: 0, identity: 1.0

gaaacgtatagtctcgcacagataccatttcaaa	CRISPR spacer
gaaacgtatagtctcgcacagataccatttcaaa	Protospacer
**********************************

2. spacer 3.4|710517|35|NZ_CP050133|CRT matches to MN693666 (Marine virus AFVG_250M158, complete genome) position: , mismatch: 7, identity: 0.8

tcattaagcctgttaatcttgatgattgctgccat	CRISPR spacer
tcattatgcctcttaatcttgatgatggaagcgaa	Protospacer
****** **** ************** *  ** *

3. spacer 3.16|710589|46|NZ_CP050133|CRISPRCasFinder matches to MK448735 (Streptococcus phage Javan349, complete genome) position: , mismatch: 8, identity: 0.826

gaaacgtatagtctcgcacagataccatttcaaacgttagaccccc	CRISPR spacer
gaaacgtatagtctcgcacagataccatttcaaaagtatcatcata	Protospacer
********************************** **   *.* .

4. spacer 3.3|710445|35|NZ_CP050133|CRT matches to NZ_MK134375 (Acinetobacter baumannii strain 34AB plasmid p34AB, complete sequence) position: , mismatch: 9, identity: 0.743

ccagcctcgtcagtttgaccgatggccatgtaatt	CRISPR spacer
ttcgacttgtcagtttgatcgatggccatgtatgg	Protospacer
.. * **.**********.*************

5. spacer 3.3|710445|35|NZ_CP050133|CRT matches to NZ_CP038010 (Acinetobacter haemolyticus strain TJR01 plasmid pAHTJR1, complete sequence) position: , mismatch: 9, identity: 0.743

ccagcctcgtcagtttgaccgatggccatgtaatt	CRISPR spacer
ttcgacttgtcagtttgatcgatggccatgtatgg	Protospacer
.. * **.**********.*************

6. spacer 3.3|710445|35|NZ_CP050133|CRT matches to NZ_CP043053 (Acinetobacter pittii strain AP43 plasmid pAP43-OXA58-NDM1, complete sequence) position: , mismatch: 9, identity: 0.743

ccagcctcgtcagtttgaccgatggccatgtaatt	CRISPR spacer
ttcgacttgtcagtttgatcgatggccatgtatgg	Protospacer
.. * **.**********.*************

7. spacer 3.3|710445|35|NZ_CP050133|CRT matches to NZ_CP033130 (Acinetobacter wuhouensis strain WCHAW010062 plasmid pOXA23_010062, complete sequence) position: , mismatch: 9, identity: 0.743

ccagcctcgtcagtttgaccgatggccatgtaatt	CRISPR spacer
ttcgacttgtcagtttgatcgatggccatgtatgg	Protospacer
.. * **.**********.*************

8. spacer 3.3|710445|35|NZ_CP050133|CRT matches to NZ_CP029396 (Acinetobacter defluvii strain WCHA30 plasmid pOXA58_010030, complete sequence) position: , mismatch: 9, identity: 0.743

ccagcctcgtcagtttgaccgatggccatgtaatt	CRISPR spacer
ttcgacttgtcagtttgatcgatggccatgtatgg	Protospacer
.. * **.**********.*************

9. spacer 3.3|710445|35|NZ_CP050133|CRT matches to NZ_CP048828 (Acinetobacter baumannii strain ABF9692 plasmid pABF9692, complete sequence) position: , mismatch: 9, identity: 0.743

ccagcctcgtcagtttgaccgatggccatgtaatt	CRISPR spacer
ttcgacttgtcagtttgatcgatggccatgtatgg	Protospacer
.. * **.**********.*************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

144052 : 154362

Streptococcus_phage(50.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_045500228.1\|144052_146248_+	anaerobic ribonucleoside-triphosphate reductase	A0A0C5KKX3	Enterococcus_phage	5.4e-283	66.7
WP_005592063.1\|146249_146387_+	hypothetical protein	NA	NA	NA	NA
WP_045500230.1\|146446_146944_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_045500232.1\|146953_147460_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_045500233.1\|147469_148015_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_015605938.1\|147980_148580_+	anaerobic ribonucleoside-triphosphate reductase activating protein	A0A0C5K925	Enterococcus_phage	1.8e-55	59.4
WP_045500241.1\|148910_150368_+	LCP family protein	A0A1X9I5X1	Streptococcus_phage	3.0e-144	61.8
WP_045500243.1\|150371_151103_+	tyrosine protein phosphatase	NA	NA	NA	NA
WP_005591513.1\|151131_151827_+	capsular polysaccharide biosynthesis protein CpsC	A0A1X9I5E1	Streptococcus_phage	2.9e-57	55.0
WP_045500246.1\|151835_152534_+	tyrosine-protein kinase	A0A1X9I5D6	Streptococcus_phage	1.9e-64	56.5
WP_045500248.1\|152553_154362_+	polysaccharide biosynthesis protein	A0A1V0SAI8	Catovirus	1.9e-23	27.5

DBSCAN-SWA_2

476412 : 486212

Streptococcus_phage(88.89%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_045500831.1\|476412_477792_+	bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU	A0A2K9L4K9	Tupanvirus	1.4e-31	35.6
WP_045500833.1\|477800_478352_+	NUDIX hydrolase	NA	NA	NA	NA
WP_045500835.1\|478364_478676_+	hypothetical protein	NA	NA	NA	NA
WP_045500837.1\|478759_479452_+	5'-methylthioadenosine/adenosylhomocysteine nucleosidase	NA	NA	NA	NA
WP_045500839.1\|479504_480392_-	YitT family protein	M1Q1P6	Streptococcus_phage	3.8e-86	55.3
WP_045500841.1\|480572_481211_+	dTMP kinase	M1PSC7	Streptococcus_phage	3.1e-82	72.1
WP_045500843.1\|481207_482110_+	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	8.1e-84	56.5
WP_005591852.1\|482119_482437_+	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	7.6e-29	60.0
WP_045500845.1\|482439_483306_+	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	3.0e-112	72.9
WP_045500847.1\|483444_484536_+	3-phosphoserine/phosphohydroxythreonine transaminase	M1Q1P2	Streptococcus_phage	9.9e-169	79.6
WP_045500849.1\|484548_485724_+	phosphoglycerate dehydrogenase	M1NSB9	Streptococcus_phage	2.4e-176	80.0
WP_045500851.1\|485858_486212_+	arsenate reductase family protein	M1PLC0	Streptococcus_phage	1.5e-33	56.4

DBSCAN-SWA_3

956606 : 966208

Streptococcus_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_045497159.1\|956606_957524_+	aspartate carbamoyltransferase catalytic subunit	A7RB08	Paramecium_bursaria_Chlorella_virus	2.8e-23	29.4
WP_045497162.1\|957670_958237_-	hypothetical protein	NA	NA	NA	NA
WP_045497164.1\|958241_959219_-	nucleoside hydrolase	NA	NA	NA	NA
WP_005590207.1\|959518_959902_+	RidA family protein	NA	NA	NA	NA
WP_045497166.1\|959969_960860_+	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	3.0e-06	29.8
WP_045497168.1\|960856_961834_+	YvcK family protein	A1IMD5	Streptococcus_phage	6.2e-154	82.2
WP_045497171.1\|961830_962742_+	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	3.9e-118	72.6
WP_045497174.1\|962775_963744_-	NAD(P)/FAD-dependent oxidoreductase	Q9JRK7	Streptococcus_phage	1.4e-49	75.0
WP_045497178.1\|963854_965171_-	FAD-containing oxidoreductase	A0A2K5B2C5	Erysipelothrix_phage	3.9e-95	43.0
WP_045497181.1\|965364_965721_+	DUF1304 domain-containing protein	NA	NA	NA	NA
WP_005592027.1\|965830_966208_+	BlaI/MecI/CopY family transcriptional regulator	X5JAW5	Clostridium_phage	1.6e-12	35.0

DBSCAN-SWA_4

1292983 : 1300249

Streptococcus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_045499432.1\|1292983_1293613_-	amino acid ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.4e-29	39.2
WP_045499429.1\|1293621_1294263_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_045499426.1\|1294707_1295004_+	hypothetical protein	NA	NA	NA	NA
WP_166492637.1\|1294992_1295145_-	hypothetical protein	Q7Y4L9	Streptococcus_phage	2.4e-09	75.6
WP_045499423.1\|1295202_1295892_+	DUF4145 domain-containing protein	A0A1S5S8U0	Streptococcus_phage	1.2e-119	92.6
WP_045499420.1\|1296161_1296935_+	helix-turn-helix domain-containing protein	A0A141E0Q5	Streptococcus_phage	9.7e-78	65.7
WP_045499417.1\|1297101_1298052_+	Abi family protein	A0A1S5S8T0	Streptococcus_phage	6.0e-178	97.5
WP_005590628.1\|1299456_1299804_-	50S ribosomal protein L19	NA	NA	NA	NA
WP_045499415.1\|1299922_1300249_-	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	3.6e-10	38.9

DBSCAN-SWA_5

1499806 : 1510175

Tupanvirus(16.67%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_045498980.1\|1499806_1501348_-	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	1.8e-54	28.5
WP_045498977.1\|1501603_1502260_-	CBS domain-containing protein	M1NSC5	Streptococcus_phage	5.0e-83	73.6
WP_045498974.1\|1502537_1503392_-	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase	A0A249XZQ2	Enterococcus_phage	3.7e-38	36.7
WP_005592360.1\|1503531_1503762_-	DUF1797 family protein	NA	NA	NA	NA
WP_045498971.1\|1504003_1506277_+\|protease	ATP-dependent Clp protease ATP-binding subunit	K4FB40	Cronobacter_phage	3.3e-126	40.6
WP_045498968.1\|1507094_1508405_-	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_045498965.1\|1508405_1509095_-	response regulator transcription factor	W8CYM9	Bacillus_phage	2.6e-34	35.4
WP_008809655.1\|1509266_1510175_+	ATP-binding cassette domain-containing protein	A0A2H4PQG7	Staphylococcus_phage	1.3e-44	45.5

DBSCAN-SWA_6

1568957 : 1581675

Streptococcus_phage(75.0%)

integrase

attL 1568844:1568875|attR 1582671:1582702

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1568844:1568875	attL	NA	NA	NA	NA
WP_045498801.1\|1568957_1570103_-\|integrase	site-specific integrase	A0A1X9I5Y5	Streptococcus_phage	4.2e-101	50.5
WP_045498799.1\|1570225_1571692_-	transcriptional regulator	NA	NA	NA	NA
WP_045498797.1\|1571962_1572781_-	hypothetical protein	NA	NA	NA	NA
WP_045498796.1\|1572827_1573406_-	helix-turn-helix transcriptional regulator	A0A1W6JQE6	Staphylococcus_phage	1.4e-09	33.0
WP_045498795.1\|1573569_1573767_+	helix-turn-helix transcriptional regulator	A0A1X9I5U5	Streptococcus_phage	4.9e-18	72.3
WP_045498793.1\|1573779_1574409_+	Rha family transcriptional regulator	A0A192Y918	Salmonella_phage	3.0e-16	42.3
WP_045498786.1\|1575592_1575925_+	hypothetical protein	NA	NA	NA	NA
WP_045498782.1\|1575917_1576199_+	hypothetical protein	A0A1X9I5U9	Streptococcus_phage	1.6e-30	72.2
WP_045498779.1\|1576333_1577194_+	phage protein	A0A1X9I6L2	Streptococcus_phage	1.8e-117	71.8
WP_045498776.1\|1577213_1578716_+	DNA primase	Q9AZI5	Lactococcus_phage	3.6e-60	36.1
WP_166492639.1\|1579052_1579229_+	hypothetical protein	A0A1X9I5U0	Streptococcus_phage	5.5e-13	64.9
WP_045498773.1\|1579240_1579699_+	hypothetical protein	A0A1X9I5V5	Streptococcus_phage	3.1e-39	53.0
WP_045498769.1\|1580554_1580908_-	type II toxin-antitoxin system PemK/MazF family toxin	A0A1S5SEX8	Streptococcus_phage	1.7e-53	87.2
WP_045498766.1\|1580891_1581107_-	AbrB family transcriptional regulator	A0A1S5SET9	Streptococcus_phage	1.8e-26	85.9
WP_045498763.1\|1581240_1581675_+	DUF1492 domain-containing protein	A0A1S5S8W3	Streptococcus_phage	9.2e-09	29.2
1582671:1582702	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP050133

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection