CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP046172	Nocardia arthritidis strain AUSMDU00012717 chromosome, complete genome	19 crisprs	cas3,WYL,csa3,c2c9_V-U4,DinG,DEDDh,casR,cas4	1	4	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP046172_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046172_1

284524-284622

Orphan

Consensus_repeat	Method
CGGCTGCCCGCCTTGCGGATACTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046172_1

>merge|NZ_CP046172|1|284524-284622|CRISPRCasFinder
CGGCTGCCCGCCTTGCGGATACTGTCCGCCCTGCGGATATTGCTGGCCGCCGCCTTGGGGGTACGGCTGCCCGTACGGCTGCCCGCCCTGCGGATACTG

>NZ_CP046172|1|1|284524-284622|CRISPRCasFinder
CGGCTGCCCGCCTTGCGGATACTG	TCCGCCCTGCGGATATTGCTGGCCGCCGCCTTGGGGGTACGGCTGCCCGTA
CGGCTGCCCGCCCTGCGGATACTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046172.1\|WP_167471468.1\|285764_286262_-\|DUF309-domain-containing-protein	unknown	unknown	gnl\|CDD\|377120
NZ_CP046172.1\|WP_167471461.1\|276207_276801_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP046172.1\|WP_167471464.1\|281127_282381_+\|tRNA-guanosine(34)-transglycosylase-Tgt	unknown	unknown	gnl\|CDD\|234642
NZ_CP046172.1\|WP_167471219.1\|291861_292032_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167471471.1\|288765_290508_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274360
NZ_CP046172.1\|WP_167471466.1\|283369_283876_+\|DUF4190-domain-containing-protein	unknown	unknown	gnl\|CDD\|379388
NZ_CP046172.1\|WP_167471474.1\|293985_294900_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223730
NZ_CP046172.1\|WP_167471459.1\|271199_273506_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP046172.1\|WP_167471469.1\|286679_286889_+\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
NZ_CP046172.1\|WP_167471463.1\|277424_279158_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP046172.1\|WP_167478905.1\|279166_281077_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP046172.1\|WP_167471473.1\|292426_293959_+\|glycosyltransferase-family-39-protein	unknown	unknown	gnl\|CDD\|379080
NZ_CP046172.1\|WP_167471472.1\|290741_291857_-\|YeiH-family-protein	unknown	unknown	gnl\|CDD\|281584
NZ_CP046172.1\|WP_167471460.1\|273689_275999_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP046172.1\|WP_167478904.1\|270913_271141_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167471462.1\|276836_277355_+\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224870
NZ_CP046172.1\|WP_167471475.1\|294942_295782_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|181334
NZ_CP046172.1\|WP_167478906.1\|284695_285613_-\|tRNA-glutamyl-Q(34)-synthetase-GluQRS	unknown	unknown	gnl\|CDD\|235573
NZ_CP046172.1\|WP_167471470.1\|286965_288597_-\|cytochrome-bc-complex-cytochrome-b-subunit	unknown	unknown	gnl\|CDD\|224209
NZ_CP046172.1\|WP_167471465.1\|282465_283242_-\|queuosine-precursor-transporter	unknown	unknown	gnl\|CDD\|376842

Protein	Function_ID	Function_description	E-value
NZ_CP046172.1\|WP_167471468.1\|285764_286262_-\|DUF309-domain-containing-protein	gnl\|CDD\|377120	pfam03745, DUF309, Domain of unknown function (DUF309). This domain is found in eubacterial and archaebacterial proteins of unknown function. The proteins contain a motif HXXXEXX(W/Y) where X can be any amino acid. This motif is likely to be functionally important and may be involved in metal binding.	1.48382e-22
NZ_CP046172.1\|WP_167471461.1\|276207_276801_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.64547e-13
NZ_CP046172.1\|WP_167471464.1\|281127_282381_+\|tRNA-guanosine(34)-transglycosylase-Tgt	gnl\|CDD\|234642	PRK00112, tgt, queuine tRNA-ribosyltransferase; Provisional.	5.26633e-179
NZ_CP046172.1\|WP_167471471.1\|288765_290508_+\|hypothetical-protein	gnl\|CDD\|274360	TIGR02946, Putative_diacyglycerol_O-acyltransferase_Mb3115, acyltransferase, WS/DGAT/MGAT. This bacteria-specific protein family includes a characterized, homodimeric, broad specificity acyltransferase from Acinetobacter sp. strain ADP1, active as wax ester synthase, as acyl coenzyme A:diacylglycerol acyltransferase, and as acyl-CoA:monoacylglycerol acyltransferase. [Unknown function, Enzymes of unknown specificity].	4.73646e-12
NZ_CP046172.1\|WP_167471466.1\|283369_283876_+\|DUF4190-domain-containing-protein	gnl\|CDD\|379388	pfam13828, DUF4190, Domain of unknown function (DUF4190). This integral membrane domain is functionally uncharacterized. One of the membrane helices contains two GXXG motifs that are usually associated with dimerization.	3.58534e-20
NZ_CP046172.1\|WP_167471474.1\|293985_294900_+\|alpha/beta-hydrolase	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	1.07826e-29
NZ_CP046172.1\|WP_167471459.1\|271199_273506_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	1.31119e-105
NZ_CP046172.1\|WP_167471469.1\|286679_286889_+\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	5.39642e-20
NZ_CP046172.1\|WP_167471463.1\|277424_279158_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	8.01578e-157
NZ_CP046172.1\|WP_167478905.1\|279166_281077_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NZ_CP046172.1\|WP_167471473.1\|292426_293959_+\|glycosyltransferase-family-39-protein	gnl\|CDD\|379080	pfam13231, PMT_2, Dolichyl-phosphate-mannose-protein mannosyltransferase. This family contains members that are not captured by pfam02366.	1.78569e-11
NZ_CP046172.1\|WP_167471472.1\|290741_291857_-\|YeiH-family-protein	gnl\|CDD\|281584	pfam03601, Cons_hypoth698, Conserved hypothetical protein 698.	1.11491e-84
NZ_CP046172.1\|WP_167471460.1\|273689_275999_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	1.155e-103
NZ_CP046172.1\|WP_167471462.1\|276836_277355_+\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	2.48897e-39
NZ_CP046172.1\|WP_167471475.1\|294942_295782_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|181334	PRK08263, PRK08263, short chain dehydrogenase; Provisional.	2.47429e-103
NZ_CP046172.1\|WP_167478906.1\|284695_285613_-\|tRNA-glutamyl-Q(34)-synthetase-GluQRS	gnl\|CDD\|235573	PRK05710, PRK05710, tRNA glutamyl-Q(34) synthetase GluQRS.	1.94661e-128
NZ_CP046172.1\|WP_167471470.1\|286965_288597_-\|cytochrome-bc-complex-cytochrome-b-subunit	gnl\|CDD\|224209	COG1290, QcrB, Cytochrome b subunit of the bc complex [Energy production and conversion].	2.80073e-71
NZ_CP046172.1\|WP_167471465.1\|282465_283242_-\|queuosine-precursor-transporter	gnl\|CDD\|376842	pfam02592, Vut_1, Putative vitamin uptake transporter.	1.47405e-48

>NZ_CP046172.1|WP_167471466.1|283369_283876_+|DUF4190-domain-containing-protein
MTNPGDSDEWWKQYGGQGVSPESGIPSASPQQPYPPSVPQYPQQPVTPPPQQQQAYPSYPQSQPNPYGQPNYAYQAPPPYQPYGYPQQQGTNGMAIGALISSLVGFATCGIGSIVGIILGVVSLNQIKQSGQDGRGMALAGIWIGIGAVVLAVLWFLVVIISAASGSH
>NZ_CP046172.1|WP_167471465.1|282465_283242_-|queuosine-precursor-transporter
MSETRTPVDVDEGSGHPAAEHAAFADAAGGYYTPIVAVFTATLIISNICATKGVAFFTGHTVAWGPFQVLPINTDGAFFLFPLAYVIGDVLSEVYGFRATRRAVYYGFACLLLMVGCFWIAIGLPAADFYENQAAFRTVVGTTPQLVLAGLAGYFIGQFLNSVTLVLIKERTKEKHLWARLLGSTVAGEFGDTLVFCSIAATAIGIHTWPDFLNYLIVGFLWKTLVEMMILPISYRCIAFLKKREPSYAPRPTSALYN
>NZ_CP046172.1|WP_167471464.1|281127_282381_+|tRNA-guanosine(34)-transglycosylase-Tgt
MLRVSDPAHFSFTIGTRLDGRHGRTGVLSTPHGDIATPAFIPVGTKATVKAVLPETMKELGAQALLANAYHLYLQPGPDIVDEAGGLSKFMNWPGPTFTDSGGFQVMSLGVGFKKVLAMEAVDVRSDDVIAAGKERLAHVDDGGVTFRSHLDGSRHRFTPEVSMGIQHRLGADIMFAFDELTTLLNTRAYQEKSLQRTHAWAQRCIDEHERLTAERTHRPYQALFAVIQGAQYEDLRRKACRDLEAIRGSAGTGFDGYGIGGALEKHNLGTIVGWCCDELPEDKPRHLLGISEPEDLFVAVENGADTFDCVNPSRVGRNAAIYVDQGRFNINTSRFRRDFTPIDETCDCYTCANYTRAYLHHLFKAKEMLAATLCTIHNERFTVRLVDRIRESIAGGYFDDYRAEFMGAWRGRIKTP
>NZ_CP046172.1|WP_167478905.1|279166_281077_+|ABC-transporter-ATP-binding-protein
MANAGSPDSKAKSFGPSLKRLLRRLAPERGYVAVIIGLAIVSVVLNTLGPYLLGKATNLVFDGVMGKSLTQFAGQSKQEVVNQLRQGGNGTLADMLNAMNVTPGLGVDFGAVGRVLLLVLALYLGASLFGWFQALLLNLVINRTVKRLRGEIEDKIHRLPLRYFDSAPRGDVLSRVTNDVDNISQSLQQTMSQLITSVLTVLGVLVMMFWISPLLAVIALLIVPAAIIVSTQIAKRSKPHFVNQWRYTGLVNAQVEEAYTGHEVVTAFGRNREVGEEFDKRNEELFNASFRAQFISGLIMPAIMFLGNLNFVLIALVGGLRVATGNISLGEVQAFIQYSRSFSQPLTQIGAMANLLQSGVASAERIFEILDAEEQSPDPVMAETRPVDRGRVEFEAVSFRYEPETPVIERLSLVAEPGHVVAIVGPTGAGKTTLVNLLMRFYELDAGAITIDGVDITEMTRDNLRSRIGMVLQDTWLFKGTIRENIGYGNPNASEEEILAAARAAYVDRFVHALPEGYDTVIDEEGTGVSAGEKQLITIARAFLSKPSILILDEATSSVDTRTELLVQHATAALRRDRTSFVIAHRLSTIRDADLIVVMEHGRIVEHGTHERLLAERGAYYRLYNAQFAAAAAADV
>NZ_CP046172.1|WP_167471463.1|277424_279158_+|ABC-transporter-ATP-binding-protein
MLIRLLRTYLAPYRAQLAGVVALQLVSVIAMLYLPSLNADLIDRGVTKGDIGYIWTSGLWMLLVSGVQIIASASSVYLGAQTAMSAGRDLRGAVLHRVGTFSAREVGQFGAPSLITRNTNDIQQVQLLIVMSVTILVMAPIMCVGGIVMALRQDLKLSWLLLVAVPLLALCMGFLVARMVPGFRAMQARIDGVNRVLREQITGIRVVRAFVRERQETWRFGVANTELTDAALRVGRLQALMFPLVMLISNVTSVAVIWFGGHAIDSGEMQIGSLTAMLTYIMQILMAVMMASFLAMMAPRAAVSADRIGEVLATESSVLPPRLPQPFKSDPAEVDFQFAEFCFPGAQQPVLRAIRFAVQPGTTTAIVGSTGSGKTTLLNLIPRLIDVTDGAVYVGGTDVRHLDLEQLRGVIGLVPQKAYLFSGTVASNLRYGDPEATDEELWRCLEIAQAADFVRDMPQGLETPVAQGGTTVSGGQRQRLAIARALVRKPRIYLFDDSFSALDVATDARLREALRPETRNAAVIIVAQRITTIRDADQILVLEDGEMVGLGTHEQLLRDCPCYQEIVESQLSAEEVR
>NZ_CP046172.1|WP_167471462.1|276836_277355_+|Rrf2-family-transcriptional-regulator
MHITAKVDYAVRTLLEIARTPRLRAASVPVVDSLHSCPSPATTLTTKADAISSAQQIPPKVLETVLSELRRAGLVVSRRGPDGGYWLAKPPKEISVADVIRAIEGPLASVRGQRPEDVSYPGIAEPLQKVWIALRVNIRAVLENVSIEDIAEGRLPAFVESLTEDPGAWARR
>NZ_CP046172.1|WP_167471461.1|276207_276801_+|TetR/AcrR-family-transcriptional-regulator
MVVRDASDTVAAGGSTKLAIRDAAVKLFGSKGFEQTSLREVADAVGITKASLYYHYASKLDLLQAIIDPIIDHLRTIVDDLPAIVRDDDGVRTVLRRHLHGMLSHRAAGALIVRDTVAIVNAMADRHPDFIDTTEVLREWLAGPNASEEARLRAAGALEVVGMALVSGEFVPDATDQLIEDTLLDMATGVLIPCHTA
>NZ_CP046172.1|WP_167471460.1|273689_275999_-|MMPL-family-transporter
MSVYLYRWGKFAFRRKWVVLPVWLLLFVLLGALGFGLKKSSSDDFSLPNLPSERATQILDKHFPGMSAGFKADAVTGTYVIGAPAGQKLTDPANRAAIDAFIAKLGGLDIVDHSKPLANPVAIAEQMGCVSADRAGDDFRSRCSAAPLSVLSQDKQDAVAVLNVPFGIKKFTDVTDADRTAAYDIAAEARNAGLTVEMSGTIAMKPGAGSSGQAEQLGYLVAFITMMVAFGALIAAFVPILTGIIGVGAASSLIFMGTSVINIPSFTLILGSMIGIALSIDYALFIVSRYKHELSVQDSPEEAAGVAIGTAGSAVVFAGMTVIIALVGLSIVGVSFLTWMGLGGAVAAFFAILVATTLLPAIMGAFGRFLFKPKIPFVARHDPENDAVVTNGMRVARLIGKAPAVALILSILVLGGLAAPAAGINLGLPGDDSQPKNTTIRKAYDLRKDGFGEGSNGILQVAVDLSNVAPDQRDAALTDLHDKLAAYDGMDYVTAPKKSEDGAGALMSGVPKSGPNNQATQDLVKHARDAEGALKDKYGIEYGVTGTTAIYADVSDVLLSKIAPYMAIVAGAAFILLVLVFRSILVPLTAALGFLLSMAATFGATVLIFQEGKLGLIADPHPLISFLPIMLIGLVFGLAMDYQVFLVTRMREEYVRGKSPKEAMISGYHHGARVVTSAAIIMISVFGGFLLESDVTAKSMGFALAAGVLLDAFVVRMVLIPSLLVLMGKWAWWMPKWLDRILPNIDIEGTKLRELQQRSARPIEEPVHV
>NZ_CP046172.1|WP_167471459.1|271199_273506_-|MMPL-family-transporter
MSVYLYRWGKFAFRRKWIVLPVWLLMLAVLGALSGQLQKPMTNDFNIPNLPSQRATEILDKHFPGMSQGFQFGAVTGTYVIAAPPGQKLTDPANRATVAALVDKLNQLGIVDHAKPLVSPLTAAEAMGCLGEDRTASSFVSKCSGAPVNVLNRTDPDSVAVLNVPFTIKEITDVTADDRKAAYDVADDARAAGLQVELSGTVAMEQQQPSGKAELIGMGVALVVMIVAFGAIVAAFVPILTAVVGLGAAMSLIFIGTSVISVPSFTTFLASMIGIALSIDYALFIVSRYKHELAVQDSPEEAAGTALGTAGSAVVFAGLTVIIALVGLSIVGIRFLTFMGLGGAIAAGFAVLTAITLMPALLGAFGRFLFTPKLPFIAQHDPEDDTSITNGMRFARLIGKAPAVALILSVLVLALLAAPATGMNLGLPGEDSMPKSSTVRKAYELRTAGFGEGANGKLQVAVDLTNVAPDRRAAALTALRDKLMSYPDMDYVTEPTMSRDGAGALLDGVPKTGPNNQDTKDLVRDARNAEGALKSEYGMEYGITGTTAIYADVDNALLSKILPYLAIVAGAAFILLILVFRSLLVPLTAALGFLLSMAATFGATVLIFQQGKFGLIAEPRPIVSFLPIMLIGLVFGLAMDYQVFLVTRMREEYVHGKPPTEAMISGYHHGARVVTSAAIIMISVFGSFLLETDATAKSMGFALAAGVLFDAFLVRMVLIPSLLALMGDKAWWIPKWLDRILPDIDVEGAKLHELRRKQSSAAPEPVHR
>NZ_CP046172.1|WP_167478904.1|270913_271141_+|hypothetical-protein
MRQRNTYERRRVLGAIVLIWILIGLVAAAQRNYLDHPTMTCPTIGTIAVNIVAGPLNYLGVNPHITDCHLPQPSQ
>NZ_CP046172.1|WP_167478906.1|284695_285613_-|tRNA-glutamyl-Q(34)-synthetase-GluQRS
MTERGAGRYAPSPSGDLHLGNLRTALLAWAFARSTGRRFLLRIDDLDRVRPGAAERQLADLTALGIDWDGPVVRQSDRLEKYAAAIDRLTAAGRTYECFCTRREIQQAATAPHGPMGAYPGTCRALTADARAEFIAAGRTPALRLRADISEFDIIDELHGPYRGPVDDVVLRRTDGVPAYNLAVVVDDADQGIDQVVRGDDLLPSTPRQAYLATLLDLPVPRYAHVPLVLNAKGQRLAKRDGAVTLADQFALGETPEQVVSALTASLGLRAGTSAELLEQFDPARLPAEPWILDENGLLQPSRYP
>NZ_CP046172.1|WP_167471468.1|285764_286262_-|DUF309-domain-containing-protein
MVERARDESGRARNARPRDSFGRPLPPGSVGVERIPDDLELPPQQTLTFAQQLLDQGLAFNAHEVLEAAWKNGPFAERMLWQGLAQLAVGLTHIQRGNRKGARTLLTRAVTRLSSYTSEEGVPYEIDQPGLINYADALLNAIDSDKKIDAEQLKPRLRVAGADPA
>NZ_CP046172.1|WP_167471469.1|286679_286889_+|DUF397-domain-containing-protein
MKVDSTGAAWRKSSHSGPDGNCVEVAFLVDGNVAVRDTKDNGIGPMLAFTPGEWDAFLSDISVGEFRRA
>NZ_CP046172.1|WP_167471470.1|286965_288597_-|cytochrome-bc-complex-cytochrome-b-subunit
MAGTVGRIAGAQANDFDERYKAAAFVKRSINKVFPTHWSFLLGEIALYSFIILILSGIYLTLFFDPSMSDVVYNGAYQPLRGVNMSRAYETALNISFEVRGGLFVRQVHHWAALLFAASIIVHLFRIFFTGAFRKPREANWVIGSILLILAMFEGYFGYSLPDDLLSGTGLRAAFSSITLGLPIIGTWMHWLIFGGDYPGNIIIPRLFIAHVLLIPGIMLALIAAHVALVWYQKHTQFPGPGRSEKNVIGVRIVPVFSLDQGAFFAFTLGVLALMGGLLQINPIWNMGPYNPSQVSAGSQPDFYMMWTDGMMRLVPAWEIYIGGHTVPGPVWGALTMGLVFTLLITYPWIERRLTRDYARHNLLQRPRDVPVRTAIGAMVIAFYLTLTLSCVNDIVAYKFNVSLNATTWVGRIGILVLPPLAYFAAYRFCIGLQRSDRAVLEHGIETGVIRRLPDGEYIELHQPLGPVDDHGHPIPLEYQGAPVPKKMNKLGLAGKPGTGAFFRADPVAESERNLAEDHAQERNQLAVLRRVQDETTGNGSRH
>NZ_CP046172.1|WP_167471471.1|288765_290508_+|hypothetical-protein
MNAVTAQDATMFWLSRRIRNDQFLLYCFADAGAPTERLREFVARRVAGIPDLGVRLRELPWNLGYPSWVRCAFAAEQFVEHELVQPDWTHLTDAIGEFLGTGVDAAVRPWRLHIFRGVRGAPGFGDEPALVAVLQISHALVDGRGAALIARALFAAEPCEVDKCEAGSCSVGSPEAGSCGTGSCEAGSCGRGSCDAGSCSASSCATDSCGTGSCSASSCGMDSCGTGSCEQVAAARGGVETAAPPDTGSGRDSSTGWSMACRVFRQAVALSSARSGASDRKALWRLPIDVPPLSRMVAAGALGIRVVPAVLSIPPRMAQTIVRGFGADRARRRLAELTAAGVVPSAAPSFEPSAVNFRDPSEVAGHRVRMIVCRADELRVPGSTVTVVVLTAISAALARYLAGRGEPVERLGAQVPMALPSATLARNNYRSLGIDLHISEPDLGARTELISKELAARRIRARHPLLNAPERVTAAVPAPLLHRDVARYPVDTVPESIAGHTVVSSVHRGAADLFFGGGVVRFTAGFPAVGSVMRLTHGVHGLGDTVTISLHADAALPDLDGYAELLRAALSEVRAMCLRY
>NZ_CP046172.1|WP_167471472.1|290741_291857_-|YeiH-family-protein
MSTATIDEDSAVDQPFTGGNVLAYLPGILLLIAVGVLGKYAQIWWNALAKHQHWTVPDIEYVLWAILIGLVITNTIGLHPIFRPGVATYEFWLKIGIVALGSRFVLGDVAKLGGTSLVQILVDMTVAGAIILTVARLLGLSGKLGSLLAIGTSICGVSAIVAGKGAIRARNSDVGYAIAAILALGAVALFALPPLGHALGLSDHEFGLWAGLAVDNTAETTATGYLYSDAAGKTAVLVKSTRNALIGFVVLGFAAYWAARGEADAVAPGLRAKASFVWAKFPKFVLGFLAVSAIATLGWLTKQQTANLANVSKWAFLLTFAGVGLNTNIRELARTGWRPLVVAVIGLLTVAVVSLGLVLFTSRVLHWGVPG
>NZ_CP046172.1|WP_167471219.1|291861_292032_-|hypothetical-protein
MNVSEPAPDQSGAAQPGASPPWLDALGKLGVDWLAVLVAGVIALLAVLDWLPKVPW
>NZ_CP046172.1|WP_167471473.1|292426_293959_+|glycosyltransferase-family-39-protein
MTTVNSPERIESREVPPFARSGVIAVALLLAAAYLISLGRPGFWGDELYFIAAGRRPSISYADQGPLVPAVAWLMDVLAPDSPFALRLPAALASVAAVAIPALIAREFGGGRRAQVLAAIGYATSVFVVASKPLCTLAFDLPLTATAVWLLIRWVRVRADWLLIMAGLAAALAIQVKWLVPGCWAALGVAVLLAGPRELLLRPALWLGSAIFAAAWAPSLIWQANHGWPQLRMARAIGTETGDFGEGPLFYVPQVILLAGLVGGALFVYGVWHILRSPALRPYRFLVVALALLTVFFIATSGRPYYGAGIVPAFIAAGAVGLGNRDYERLPKIAGAALITVSAVLVLIPLSVLPLPESGIHEPAVTTKQAIQRGFLYGQTGWAKLAAATATAYGELPPDERDTAVIVAESYWQASAVDHYRRALPAVYSPNRGYGYFGSPPDSATTVVYIGGDPAKLRTEFADVRLLVELNDRLGFPGVTSGVTIWKCGRPTRPWSQAWPDMLELDQHYL
>NZ_CP046172.1|WP_167471474.1|293985_294900_+|alpha/beta-hydrolase
MRRMLAAGAIALLMSPIGHVARAEPVATVLPAITYATADGRDLLLDLYLPATGPAPAPLIVYIHGGAWKFGSRTNDGNAMPWGTVAGMAATLTARGYAVASVEHRFSTQVRWPAQLYDVKAAVRWLRANAGEYHLNPEKVAAWGDSSGGQLAAMLGVTGDDRRFEGDLGNADQSSRVQAVVDWFGPTDLRTMDRQRAPFGLRHDAAGSPESDLLGCVPSSCPELAGDASPIDHISDRTPPFLIEHGRFDHIVPFGQSPEFYDALTAAGVPAEFHAYDTDHEFLGPTPMAEILDPFYRFLDRELR
>NZ_CP046172.1|WP_167471475.1|294942_295782_-|SDR-family-NAD(P)-dependent-oxidoreductase
MTRTWFITGANRGLGRAFTLAALAHGDRVVATARDPRGMADIADPRLTVLPLDVRERDRVFATVDQAFELAGSIDVIVNNAGYGLVGALEELDERRIRDQMDTNFYGALWVSQAAIPHLRKQGSGHIVQISTVGAVGSLPLFSMYNASKWALEGFASSLADELRPFGIRVTMAQLGGFDTDWAKSSMKFAEPLPAYDELRSGILGMSGYPDPAAPPPAVDSEWVEAAPEVAAAELISLVEMAEPPVRKIIGPGAHQMVAMALDQRRLDYATDPEFTWPS

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Crispr_ID: NZ_CP046172_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046172_2

826491-826579

Orphan

Consensus_repeat	Method
GCCCGCTGTTCCGGCTCCGATCACTGAGAGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046172_2

>merge|NZ_CP046172|2|826491-826579|CRISPRCasFinder
GCCCGCTGTTCCGGCTCCGATCACTGAGAGCCACTGCTCCGAAAGCCGGGTCGATGTGCCCGCTGTTCCGGCTCCGATCACCGAGAGCC

>NZ_CP046172|2|2|826491-826579|CRISPRCasFinder
GCCCGCTGTTCCGGCTCCGATCACTGAGAGCC	ACTGCTCCGAAAGCCGGGTCGATGT
GCCCGCTGTTCCGGCTCCGATCACCGAGAGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046172.1\|WP_167471895.1\|825139_825991_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167471892.1\|823078_823684_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP046172.1\|WP_167471902.1\|832504_834136_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366675
NZ_CP046172.1\|WP_167478971.1\|827948_828317_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167478972.1\|834895_835552_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP046172.1\|WP_167471898.1\|829323_830538_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167471900.1\|831068_831491_-\|SnoaL-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|378915
NZ_CP046172.1\|WP_167471897.1\|828444_829188_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|377092
NZ_CP046172.1\|WP_167471903.1\|834272_834899_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP046172.1\|WP_167471891.1\|820378_821386_-\|adenylate/guanylate-cyclase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143636
NZ_CP046172.1\|WP_167471888.1\|818428_818863_-\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NZ_CP046172.1\|WP_167471901.1\|831625_832498_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182137
NZ_CP046172.1\|WP_167471889.1\|818913_819525_+\|TIGR03086-family-protein	unknown	unknown	gnl\|CDD\|274424
NZ_CP046172.1\|WP_167478968.1\|821481_822282_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP046172.1\|WP_167471890.1\|819589_820357_-\|RNA-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|211346
NZ_CP046172.1\|WP_167471893.1\|823804_824263_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167471894.1\|824414_825140_+\|ParA-family-protein	unknown	unknown	gnl\|CDD\|349760
NZ_CP046172.1\|WP_167471896.1\|827296_827815_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP046172.1\|WP_167471899.1\|830574_831024_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167478969.1\|822286_822955_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP046172.1\|WP_167471892.1\|823078_823684_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	1.31109e-11
NZ_CP046172.1\|WP_167471888.1\|818428_818863_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	1.54541e-15
NZ_CP046172.1\|WP_167471902.1\|832504_834136_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|366675	pfam01494, FAD_binding_3, FAD binding domain. This domain is involved in FAD binding in a number of enzymes.	2.86041e-95
NZ_CP046172.1\|WP_167471900.1\|831068_831491_-\|SnoaL-like-domain-containing-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	6.87296e-15
NZ_CP046172.1\|WP_167471896.1\|827296_827815_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	8.25147e-37
NZ_CP046172.1\|WP_167471903.1\|834272_834899_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	5.7524e-13
NZ_CP046172.1\|WP_167478968.1\|821481_822282_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.85083e-24
NZ_CP046172.1\|WP_167471901.1\|831625_832498_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|182137	PRK09906, PRK09906, DNA-binding transcriptional regulator HcaR; Provisional.	1.3867e-40
NZ_CP046172.1\|WP_167471891.1\|820378_821386_-\|adenylate/guanylate-cyclase-domain-containing-protein	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	6.49301e-34
NZ_CP046172.1\|WP_167471890.1\|819589_820357_-\|RNA-pseudouridine-synthase	gnl\|CDD\|211346	cd02869, PseudoU_synth_RluA_like, Pseudouridine synthase, RluA family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and TruA. Pseudouridine synthases catalyze the isomerization of specific uridines in a n RNA molecule to pseudouridines (5-ribosyluracil, psi) requiring no cofactors. E. coli RluC for example makes psi955, 2504 and 2580 in 23S RNA. Some psi sites such as psi1917 in 23S RNA made by RluD are universally conserved. Other psi sites occur in a more restricted fashion, for example psi2819 in 21S mitochondrial ribosomal RNA made by S. cerevisiae Pus5p is only found in mitochondrial large subunit rRNAs from some other species and in gram negative bacteria. The E. coli counterpart of this psi residue is psi2580 in 23S rRNA. psi2604in 23S RNA made by RluF has only been detected in E.coli.	3.80424e-52
NZ_CP046172.1\|WP_167471889.1\|818913_819525_+\|TIGR03086-family-protein	gnl\|CDD\|274424	TIGR03086, TIGR03086, TIGR03086 family protein. This family, like pfam07398 and TIGRFAMs family TIGR030834, belongs to the larger set of probable enzymes defined in family TIGR03083. Members are found primarily in the Actinobacteria (Mycobacterium, Streptomyces, etc.). The family is uncharacterized.	2.61832e-32
NZ_CP046172.1\|WP_167471894.1\|824414_825140_+\|ParA-family-protein	gnl\|CDD\|349760	cd02042, ParAB_family, partition proteins ParAB family. ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the initiation of DNA replication. ParB regulates the ParA ATPase activity by promoting nucleotide exchange in a fashion reminiscent of the exchange factors of eukaryotic G proteins. ADP-bound ParA binds single-stranded DNA, whereas the ATP-bound form dissociates ParB from its DNA binding sites. Increasing the fraction of ParA-ADP in the cell inhibits cell division, suggesting that this simple nucleotide switch may regulate cytokinesis. ParA shares sequence similarity to a conserved and widespread family of ATPases which includes the repA protein of the repABC operon in Rhizobium etli symbiotic plasmid. This operon is involved in the plasmid replication and partition.	1.0898e-17
NZ_CP046172.1\|WP_167471897.1\|828444_829188_-\|ABC-transporter-permease	gnl\|CDD\|377092	pfam03649, UPF0014, Uncharacterized protein family (UPF0014).	1.61278e-35
NZ_CP046172.1\|WP_167478972.1\|834895_835552_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	8.01118e-39

>NZ_CP046172.1|WP_167471895.1|825139_825991_+|hypothetical-protein
MPPQRRKGSIGGAPNSAARTVNPLSDKAEHTPPVSPLRDAEWRPAKITPAAEDAIFTGVNVLTMPLPAAGDGPLSDQEQAQLSACESSIDKLRMAFWAAGRALQIVRDGRLYRQSHGTFDDYVEQRWDMQRSYAHKLIRAWPLAARLHPVAPAINEGQVRELLPVAAEYGEDAAVTVYTTIANSGDAKVTASKLRAAVSVLPDHFDETEVVERLRAWLRGDLVDEPRGESGERVLDLFSTVESRLAALTRRVVRGSSNDPAAAREFAAKLRTLAEQIEEQITA
>NZ_CP046172.1|WP_167471894.1|824414_825140_+|ParA-family-protein
MTNSVAQLDLPKPLVITLGNLKGGVGKTTSAFFLASYFALVHELRVLVIDADPLSQTGYSWYRRLQKGEVEVPFELIAFPSRHVNDCITDNSAKFDVVIVDAGGESAEIFKAAIPQSDELILLTSVSPSEVKRVPSTYKAAEEAAAGSGREIRVRVLMTKVPVTMKNGVNVSTEYRVQRANLEDAGYDVFDSYLSAWKWYREAADGEVGDGAENPIADLGEYRQVGDELLSPYRAVMEVSA
>NZ_CP046172.1|WP_167471893.1|823804_824263_+|hypothetical-protein
MTTETVKIHVDHETTKRLGDWTSATGFDVKARYGSVVIDLRSPRIEGDEPIEVHVNLDHAMVKLLVPEYAVIDQTELEWTGRGRVKDFARPQQAAGRVIRLTGTSAKSEFRVHRGGIAILSALFSREFLEDARRANKEGRTPTLLDPENAPR
>NZ_CP046172.1|WP_167471892.1|823078_823684_-|PadR-family-transcriptional-regulator
MTASTQFKRSPLAMALLGILHLEPMHPYAIQRRIKEWGKDKVVNVAQRAALYKTITRLQEAGLVAVRETGRDQQYPERTVYEITDAGRAACLGWITEMIGEPRYEFPEFPAALSFVMLLGPDAARVELDRRAKALRANLTELDNDAAKVAAIGLPRVTMLEDEYNRAVMEAELRWLEGVVADLASGELTWSWESLAQYQNS
>NZ_CP046172.1|WP_167478969.1|822286_822955_-|hypothetical-protein
MSRIAAVAALVLVPMVTQVQAQAGPASCAAGNPLRPTAELFATDNTSTITDPADERLRTRLDGFELQVDGIVAANIALPVGSTLVSGVFWSEDQRQTTYERSREFHLACVTGPDLHNLADQVRAQFRQESVLTFEPLPADAPGVDGFTATVPGIDVRRFHDALVADPVARQRLVGGSVTEDNRLIVVADIADYALAQRFVTELGGDWNAADVRFGDREFVGS
>NZ_CP046172.1|WP_167478968.1|821481_822282_+|alpha/beta-hydrolase
MNVRSDGPADAATVLLIHGFAGSLHWFDRVTELLVPAYRVLRVDLRGHGRTGGRSGFDPESQSRAIISALDALDIRDAVALGHSFGADVALAVGRRSERVSGVGIIGQAPDFSYSKLPAAGVLLTLPVLGALLHRLTPAAAIRFGMRTAFARGFAARDAFDRPDRPVLDYRAMHPGMFREVLVDRPARLRGEPLDAQLRAIAKPALVIHGSADQLYDTARTVARYTAAGARVEVVDGAGHSPNIERPNEFARLVGEFRTETGLRAG
>NZ_CP046172.1|WP_167471891.1|820378_821386_-|adenylate/guanylate-cyclase-domain-containing-protein
MVDNQMAELVQSVVESYLLGGTRRYNRAEVAERSGVSPEVSKRLWMALGFPANPDDTDDYTDADVAAVRDFRSLSVVASSDIRQQSAAARTLGQSMARLAEWQADLVLAEIETRITSARAAEPDRDPAEIARTATEATIAVLEELQTYAWRRHLAAALARSFDGAVIAEDSTRELAVGFADMVGYTRLTRHLHPDELSMLLEAFESTTTAAITENGGWVIKNVGDEVMFAAEHAIDAARIALAIQESTMMVAGTPELRVAIAYGPVLQRFGDLYGSVVNIASRLTGVARPGTILVDDHAAAELANEPEFTIRNLRSVRVRGFSRLRPHLLRADEK
>NZ_CP046172.1|WP_167471890.1|819589_820357_-|RNA-pseudouridine-synthase
MDIDWSQLRARCLLLEDAGVLALNKPAGISVTGERHDTDIVELAAASGETLYPVHRIDKVTSGLVLLAKELPAHGELTRQFNKQTATKAYLAVVDSTGLPDRGVIDLPLSVGRKNRVRIAAPRESIRTEDDRWFVRQSDLLSGKNYPSITEFATLLRTESRTVLALRPITGRRHQIRVHLAWIGYPIVGDPLFDRTGTQPRTHLHSWRLGLTASWRTPPVLDMEAVPGEDFWVPVGVGADEAAGLLEQGAALLAG
>NZ_CP046172.1|WP_167471889.1|818913_819525_+|TIGR03086-family-protein
MSTITDADLVAMHARSLRLTTDLVETVTPDQLNNETPCAGWNLRDLLTHMTIENHGFAESARGRGGDISLWQTRELADPIGEYLTASADLLDAFGVDDISEREFLLPGIMPGVPFKAEHAVRFQLVDCVVHAWDVARSIGKNIELDSDPEMADETLAIARIVPGGADRLKEGAAFGPILEVPEGSGKLDEILLLLGRDPKWGN
>NZ_CP046172.1|WP_167471888.1|818428_818863_-|winged-helix-turn-helix-transcriptional-regulator
MPEVTRPDLAAMIAPLGHALMVAEQPILDRNGLSMWAYVVLLRLDDDPIYTQAALAKATRADKTRIIAILDDLQRRGLIRREPNPADRRVNMVSLTPEGRVLRDRTQREIQEQEEVLLANLPAADRRAFLRALQTLHDIVNQPE
>NZ_CP046172.1|WP_167471896.1|827296_827815_-|helix-turn-helix-transcriptional-regulator
MPRQPFGDIACSIARATGIIGERWTPLIVRDLFAGMTRFEDLRRDLGIATNVLSTRLETLERNGIVERREYRSAPVRHEYVLTAKGYDLYPIIAAIVAWGDKWAAPDGPPALVTHTDCGRHTSARMVCAECGGELNHENTYATVGPGARPGPGTALIGEFLTDPRNSSTTRT
>NZ_CP046172.1|WP_167478971.1|827948_828317_+|nuclear-transport-factor-2-family-protein
MDGMVAALAPDAELISPLSSRIVIRGRDDLRIALGVIYGSLTDLRWTEFIGSGSTRVAVSEAGIGRFGITDAMIIELAEDGRIRRIRPHLRPWLGTTVFALLGAAKLGRYPGLMRRALRPDG
>NZ_CP046172.1|WP_167471897.1|828444_829188_-|ABC-transporter-permease
MNSVATPGIALAALCTVLVAAAAAVYWFAELDSAWVPPRAAARGATQLAAVALVLAAALAHLWSSLLVLAVMFVAAVFTSARRSGSGCTAAWLALALAAGMAAVLPMMLVSGVVPIKGVALVPIGGIVLGGAMTATSLAARRALDAIEQRWGEVEAALSLGLTERDARMEVIRRTAADALLPGVDQTRTVGLVTLPGAFVGVLVASGSAYQAGAVQILVLVGLLLAQSCSVAVTIELVARTKVRRPR
>NZ_CP046172.1|WP_167471898.1|829323_830538_+|hypothetical-protein
MTRVTPSRRLVSREQSRTELISLACRLRDEWSRVALSTDPADRTAAESAIAELYRLVGASPPEFVWVPSPTAAVEVLRDDPAGSTDLTVLHRPLSSWPVRSRLVQAKSQLAQRLEDRTQRRFPTEPWAWYGPEATAMSPRALAASAESTGRILDSVVRQPLLNTLRDNLYQPMRRMLLTENGVNSPVAGHEQYDTWGLAYFGLLRDGGCLRFGHADAHHLDQWLTLARSAGWWWPGERRCVLAERPAAIHTEAFGDVRLRPHHPDRRAVEFVDGTGIFAVHGTAVPEWVITGPTVELIRRERNIEVRRVAIERFGWDAYIDAAGLELVAAAPDPGNPGGMLRLYHVPRFASSRVLLVLNGSRERDGTRRRYGINVPAAMTDPVAAAGWSYGLSGAQYAQLVRRT
>NZ_CP046172.1|WP_167471899.1|830574_831024_+|hypothetical-protein
MQKTLAELTARTGVEVLDHLEREVLVPVVAGLQAQGDLIVVPLAMADGIQLPAHGAWNPVPAAGIEVVRGATGANPHVLVADPGKCRWTTLVFDHTGLAIGCLDTSDVAYLLHPEHGGSGIAPGCYVIRRQRERTGAPGSWGATRMIAD
>NZ_CP046172.1|WP_167471900.1|831068_831491_-|SnoaL-like-domain-containing-protein
MTTTQILGAEQVVRRYFDALKAGENDIVRDSFADEATFWYPGDLPFSGTWTGRDQIVDGFLGTAFALLDPDKEVRIEVTNFFAADDQVTVEWSSWGTVRNGNPYHNKNIAVFRVADGKIVTVREYANAQNWERALRDPQA
>NZ_CP046172.1|WP_167471901.1|831625_832498_+|LysR-family-transcriptional-regulator
MELRQVRYFLTVAEELHFGRAARRLHIVQPAVSQQVRRLERELGLDLFDRTTRTVTLTPAGHAFLPHARTMLAAEQAALEEISLLRADAVLRIGTNVGLGSRLDRVLATLAEREPRLSVELVSASPAARLDLVRSGELDAAFIRGTTASSGLDLLPVWEDSLVAALPAAHPLAEGESVALAELAALPLRIVTREQNPYLVDLVVEACRATGSEPVLGPAFTTDQDTLAAIGNGKPSWTVFYAAKAEILYAPRIAFRPIVSPALTIQTYLAVRPSAAASRLAPLLAACDLA
>NZ_CP046172.1|WP_167471902.1|832504_834136_-|FAD-dependent-oxidoreductase
MTETQKTAVLIVGGGVTGLSAALFLARQGIRPILVERHPSTAIMPQARAFNPRTMEIYHALGLEPEILAHQSILLQFPEMIGAETLAGEERFRIDMAAGARIDPEVSPAQWAHIDQDELEIILRAHAERDGADVRFHSEMTSFEVTDAGVRAIVRDRATGNEYPIDADYLIAADGSRAGVRNRLGIGVDESMPSTHLAFIVFDADLTEALRGRRFTLGYFDAPTRGSVLLPLRQEGRWQLAVPYEPETGDGTDTFTEERCIEWVRAAIGAPELELTLVSPVPGWPHKVSLTTMGGWVARRYRDRRVFFAGDAAHIVPPSGSFGASTGIADAHNLAWKLTAVLKGQAGPELLDTYEDERRPVARLTLSTAIQLLHSRATAGQEDISESENILLIFGYRYNSTAVAAEQLIPDELIEDPRIPSGCPGLRAPHVWLERDGVRFSTTELCTGTFSVLIGQDGADWLAAAEKVAAATGIELNTFRVGVDVADPEGRFLDSFGITATGVTLIRPDGFVAWRAPQSVTHPENALRQVLLAILARDNAEVG
>NZ_CP046172.1|WP_167471903.1|834272_834899_+|TetR/AcrR-family-transcriptional-regulator
MPPSKPRRSPSPQDRQRDPERTRKLIIDAAVAEFAAHGYAGARVSAIAARAGVNQQLISYYFEGKEGLYQAISEKWWERADELATPDMTYAAKLRAFALEQLHNPDGVRLFAWGGLEYAGPADDPDHETRSERLRSDIDDFRDRQAAGELPAAIDPVCLSAMLMSAAMAPTLLPQVIEGTGGVDPRSPEFLEHFADQVALVARLLGLD
>NZ_CP046172.1|WP_167478972.1|834895_835552_-|GntR-family-transcriptional-regulator
MLTSFLPRRNMRDEIIEKLRGAVITGELRPGVVYSAPGLAEQFGVSPTPVREAMIDLAKEGLFETLRNKGFRVREPSDQELDNLAEIRLLIEAPTVRKVAEAGIPGPILAELRALADGIEKAAIELDFITYISIDTEFHCRLLGLAGNNELVETVRSLRARSRLYGVRPLAEQGKLIPSAHEHVEVLDLIERGDAAGAEELIRRHIGHVRGIWAANGS

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Crispr_ID: NZ_CP046172_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046172_3

1496059-1496231

Orphan

Consensus_repeat	Method
GAATCCGGCCCCTCCGCAGCCGAATT	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP046172_3

>merge|NZ_CP046172|3|1496059-1496231|CRISPRCasFinder
GAATCCGGCCCCTCCGCAGCCGAATTCGGTCCGCCGGTCGGTGAGTTCGGCCCGCCCGCAACCGAATCCGGCCCTTCCGCAGCCGAATTGCGGCACTCGACAACGGAACCCGGCCAGCCCGGAGCCGAGTTCGGGCCGCCCACAGCGGAATTCGGCGCCCCGGTGTCCGAATC

>NZ_CP046172|3|3|1496059-1496231|CRISPRCasFinder
GAATCCGGCCCCTCCGCAGCCGAATT	CGGTCCGCCGGTCGGT
GAGTTCGGCCCGCCCGCAACCGAATC	CGGCCCTTCCGCAGCCGAATTGCGGCACTCGACAACG
GAACCCGGCCAGCCCGGAGCCGAGTT	CGGGCCGCCCACAGCG
GAATTCGGCGCCCCGGTGTCCGAATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046172.1\|WP_167472353.1\|1487681_1488461_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|236183
NZ_CP046172.1\|WP_167472351.1\|1485733_1486075_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167472352.1\|1486163_1487681_-\|phospho-sugar-mutase	unknown	unknown	gnl\|CDD\|100092
NZ_CP046172.1\|WP_167472362.1\|1501849_1503094_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP046172.1\|WP_167472350.1\|1484888_1485512_+\|uracil-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234653
NZ_CP046172.1\|WP_167479020.1\|1490927_1492070_+\|amidohydrolase	unknown	unknown	gnl\|CDD\|349936
NZ_CP046172.1\|WP_167472361.1\|1500112_1501846_+\|glycerol-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|223651
NZ_CP046172.1\|WP_167472367.1\|1506667_1507240_+\|dihydrofolate-reductase-family-protein	unknown	unknown	gnl\|CDD\|334719
NZ_CP046172.1\|WP_167472357.1\|1492814_1494218_+\|NAD(P)H-quinone-dehydrogenase	unknown	unknown	gnl\|CDD\|236112
NZ_CP046172.1\|WP_167472359.1\|1497127_1498303_+\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP046172.1\|WP_167472354.1\|1488754_1489459_+\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|119339
NZ_CP046172.1\|WP_167472356.1\|1492130_1492610_-\|gamma-glutamylcyclotransferase	unknown	unknown	gnl\|CDD\|372719
NZ_CP046172.1\|WP_167472360.1\|1498459_1499959_-\|glycerol-kinase-GlpK	unknown	unknown	gnl\|CDD\|234594
NZ_CP046172.1\|WP_167472363.1\|1503135_1503795_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP046172.1\|WP_167472366.1\|1506315_1506456_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167479022.1\|1504191_1504764_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP046172.1\|WP_167472364.1\|1503889_1504096_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167479021.1\|1494737_1495721_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223021
NZ_CP046172.1\|WP_167472355.1\|1489557_1490790_+\|M20-family-metallopeptidase	unknown	unknown	gnl\|CDD\|349921
NZ_CP046172.1\|WP_167472365.1\|1504811_1506173_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274593

Protein	Function_ID	Function_description	E-value
NZ_CP046172.1\|WP_167472353.1\|1487681_1488461_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|236183	PRK08202, PRK08202, purine nucleoside phosphorylase; Provisional.	1.88578e-120
NZ_CP046172.1\|WP_167472356.1\|1492130_1492610_-\|gamma-glutamylcyclotransferase	gnl\|CDD\|372719	pfam13772, AIG2_2, AIG2-like family. This family is found in bacteria and metazoa.	5.31747e-30
NZ_CP046172.1\|WP_167472352.1\|1486163_1487681_-\|phospho-sugar-mutase	gnl\|CDD\|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NZ_CP046172.1\|WP_167472362.1\|1501849_1503094_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.9151e-34
NZ_CP046172.1\|WP_167472350.1\|1484888_1485512_+\|uracil-phosphoribosyltransferase	gnl\|CDD\|234653	PRK00129, upp, uracil phosphoribosyltransferase; Reviewed.	4.00855e-101
NZ_CP046172.1\|WP_167479020.1\|1490927_1492070_+\|amidohydrolase	gnl\|CDD\|349936	cd08014, M20_Acy1-like, M20 Peptidase aminoacylase 1 subfamily. Peptidase M20 family, uncharacterized subfamily of uncharacterized bacterial proteins predicted as putative amidohydrolases. These are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. Aminoacylase 1 (ACY1) breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	0
NZ_CP046172.1\|WP_167472361.1\|1500112_1501846_+\|glycerol-3-phosphate-dehydrogenase	gnl\|CDD\|223651	COG0578, GlpA, Glycerol-3-phosphate dehydrogenase [Energy production and conversion].	0
NZ_CP046172.1\|WP_167472357.1\|1492814_1494218_+\|NAD(P)H-quinone-dehydrogenase	gnl\|CDD\|236112	PRK07845, PRK07845, flavoprotein disulfide reductase; Reviewed.	0
NZ_CP046172.1\|WP_167472359.1\|1497127_1498303_+\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	3.39633e-113
NZ_CP046172.1\|WP_167472354.1\|1488754_1489459_+\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	8.27315e-41
NZ_CP046172.1\|WP_167472360.1\|1498459_1499959_-\|glycerol-kinase-GlpK	gnl\|CDD\|234594	PRK00047, glpK, glycerol kinase GlpK.	0
NZ_CP046172.1\|WP_167472363.1\|1503135_1503795_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.26871e-69
NZ_CP046172.1\|WP_167479022.1\|1504191_1504764_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.4072e-05
NZ_CP046172.1\|WP_167472367.1\|1506667_1507240_+\|dihydrofolate-reductase-family-protein	gnl\|CDD\|334719	pfam01872, RibD_C, RibD C-terminal domain. The function of this domain is not known, but it is thought to be involved in riboflavin biosynthesis. This domain is found in the C-terminus of RibD/RibG, in combination with pfam00383, as well as in isolation in some archaebacterial proteins. This family appears to be related to pfam00186.	1.44674e-34
NZ_CP046172.1\|WP_167479021.1\|1494737_1495721_+\|hypothetical-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	5.18363e-09
NZ_CP046172.1\|WP_167472355.1\|1489557_1490790_+\|M20-family-metallopeptidase	gnl\|CDD\|349921	cd05672, M20_ACY1L2-like, M20 Peptidase aminoacylase 1-like protein 2-like, amidohydrolase subfamily. Peptidase M20 family, aminoacylase 1-like protein 2 (ACY1L2; amidohydrolase)-like subfamily. This group contains many uncharacterized proteins predicted as amidohydrolases, including gene products of abgA and abgB that catalyze the cleavage of p-aminobenzoyl-glutamate, a folate catabolite in Escherichia coli, to p-aminobenzoate and glutamate. p-Aminobenzoyl-glutamate utilization is catalyzed by the abg region gene product, AbgT. This subfamily includes Staphylococcus aureus antibiotic resistance factor HmrA that has been shown to participate in methicillin resistance mechanisms in vivo in the presence of beta-lactams. Aminoacylase 1 (ACY1) proteins are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in the protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. ACY1 breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	4.36727e-160
NZ_CP046172.1\|WP_167472365.1\|1504811_1506173_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|274593	TIGR03467, HpnE, squalene-associated FAD-dependent desaturase. The sequences in this family are members of the pfam01593 superfamily of flavin-containing amine oxidases which include the phytoene desaturases. These sequences also include a FAD-dependent oxidoreductase domain, pfam01266. The genes of the family modeled here are generally in the same locus with genes involved in the biosynthesis and elaboration of squalene, the condensation product of the polyisoprenoid farnesyl pyrophosphate. This gene and its association with hopene biosynthesis in Zymomonas mobilis has been noted in the literature where the gene symbol hpnE was assigned. This gene is also found in contexts where the downstream conversion of squalene to hopenes is not evidence. The precise nature of the reaction catalyzed by this enzyme is unknown at this time.	6.41524e-84

>NZ_CP046172.1|WP_167479021.1|1494737_1495721_+|hypothetical-protein
MATLFAAPAGAAPQDTPTVPPTVPPTPAPQQPGSDVPTSETPAPKADNTPTPAPSQTPNPSPSQPGVTTPDPNQAPPKPQSPTQPGVTTPRIAPLPVPGQQGGDMPAVMPDQPGVQQPKQPGTQPQQPGGTQPQQPGQAKPQQPSGDANNAQPKPPADTLVQPPQQPRWQSPHLEAAPQAPVVEMTGPHLEIGANVDGGAVLPGFVANTHHFSNKDGYVGTVGYHTPTGQGEAGISVEFVDINTVKVTSYTGGEGLADSKNTTVIDTTQANIAKAAVEHWIESQPGGAAALEAARHAVPPVLPPGDIAPQTADVGGVTTQWGGSLQY
>NZ_CP046172.1|WP_167472357.1|1492814_1494218_+|NAD(P)H-quinone-dehydrogenase
MTRIAIIGGGPAGYEAALVASQHGASVTLIDCDGIGGACVLWDCVPSKTFIASTGVRTDLRRARGLGINLDPSNAEIQLGEVNARVKELALAQSSDIRSKLQAAGVQILQGRGELIDPAMGLAAHRVLAKLATGVEQTLEAEVVLIATGASPRVLPGAEPDGERILNWRQLYDLKELPETLVVVGSGVTGAEFVSAYTEMGVQVKLVASRDRVLPGEDADAALVLEDALAERGVELVKHGRADAVERTADGIVVKLADGRTVTGSHALMTVGSTPNTENLGLERVGIELDRGGYLRVDRVSRTSVPGIYAAGDCTGLLPLASVGAMQGRIAMYHALGEGVSPIRLKTVASAVFTRPEIATVGVSQTAIDNGEVPARTVMLPLNTNPRAKMSGLRRGFVKIFCRPATGVVIGGVVVAPIASELILPIAMAVQNNLTVNDLAQTFSVYPSLTGSVTEAARQLMRHDDLD
>NZ_CP046172.1|WP_167472356.1|1492130_1492610_-|gamma-glutamylcyclotransferase
MPIYAAYGSNMDSSQMLERCPHSPLAGTGWLEGWRLTFAGDDIGWEGPLATVVEDPGSRVFVVLYDVSPEDEQRLDRWEGSDFGIHKKIRLRVTRNPGADPEPTLAWLYVLDAYEGGLPSARYIGVIADAAEKAGAPEDYVHALRTRNSRNVGPGNFPG
>NZ_CP046172.1|WP_167479020.1|1490927_1492070_+|amidohydrolase
MVDRWLAEHTEDLVHWRRHIHANPELSRTEFGTTELVSTWLTKAGLTPQILPGGTGLICDIGPDGPRIGLRADMDALPLQEFTGLSFASTVPGVSHACGHDAHTAILLGTALALSEVDELPIGVRLVFQPAEEVMPGGAIDVVATGAMEGVERIFALHCDPRLEVGRIGVRVGPITSAADTVELVLDSPGGHTSRPHLTSDLVYAIGTVITGLPGLLSRRIDPRTSTVMVWGAVSAGKAPNAIPQTGMLTGTVRTGDHATWSLLEPMVREIVDGLLAPTGVRYQLNYKRGVPPVVNDEEAVRMFEDAIRRLGPDALADTMQSSGGEDFSWYLEEVPGAMARLGVWSGHGEQLDLHQPTFDIDERALAVGVRVLSNIVLNA
>NZ_CP046172.1|WP_167472355.1|1489557_1490790_+|M20-family-metallopeptidase
MPPARSGTDDEPGGAITAAAEQVSDRAIAAAAARLIDLSHSIHAEPELAFEETRSVAKTIAPLAERGFEIETGVADLPTAFRASYGSGPLTVGICAEYDALPEIGHACGHNIIAASSVGAALGLAEVADALGLTVLVLGTPAEESGGGKVLMLERGVFDDVAMAMMVHPGPFDIVGAHSLAMADLSIVFHGREAHASAAPEEGRNAGDAVTIAQVALGLLRQHLQPGQQLHGIVGNGGVAPNIVPGRAELLYYLRAVDSASLDDLMRRAFDCFAAGALATGCTHEIRTVAPTYTELTPDPALLCAYREHIVDLGRVPIAPELERQRPLGSTDMGNVTNVIPGIHPVIGIDAGGAVTHQPGFAEASVNASADRAVTDGAFALARTAITVARDEVHRDRLLQRLVQRQEDIR
>NZ_CP046172.1|WP_167472354.1|1488754_1489459_+|enoyl-CoA-hydratase/isomerase-family-protein
MPYLERDGDVFVVYLGSEGQTDSENRFHPDWIDEFHGLLDKVEASEGPAALVTTATGKFYSNGLDTDWLFGNLGEMHGYLDRVHSLYTRLLQFPLPTVAAINGHAFGAGAMLATSHDFRVMRADRGFWCLPEVHLGMPFTIGMNALLTERLSNQVCVQAMTTGHRFPADEAIAAGIVDDKADAEALLSTAVARAAALVGNRKPNLPVIKRALHAKALAGLAVATTPENLAFAAG
>NZ_CP046172.1|WP_167472353.1|1487681_1488461_-|purine-nucleoside-phosphorylase
MLAEQAAEAIAERTGVPRHRVAVVLGSGWQEAAAEIGAPTASVPMPDLPGFGTPSAQGHVGMVHSVSVGETPVLLLMGRQHLYEGYQPAEVVHPVSAAIAAGAEIVVLTNAAGGIRDGLSVGEPVLISDHINLTARTPLTGATFVDLVDAWDPELRALAREIEPGLTEGVYAGLTGPQYETPAEIRMLRTMGADLVGMSTVLEAIAARALGARVLGISLVTNLAAGVTGAHLSHAEVLAEGHAAAPRLGKLLRGVVERI
>NZ_CP046172.1|WP_167472352.1|1486163_1487681_-|phospho-sugar-mutase
MLRFGTAGLRGPLQDGPDGMNVDTVGRATAGLVDWLRGRCLGGGRVVVGRDARHGSAEFATVTAEIFAAAGFPVTLLPHPLPTPVVAYAVRELGAVAGVQITASHNPATDNGYKVYLDGGSQLIAPADTEIERCIDAVREPFDRTPVAPSDDELPQRYLARVGELPALIGGPGARASIRIALTPMHGVGGEMALEALAAAGFSDVHVVREQFAPDPDFPTVAFPNPEEPGATDLLLALAERIDADLAIALDPDADRCAVGVPGPDGWRMLRGDETGVLLADCVLRTATPNALVATTIVSSRLLSKLAPARGARYAETLTGFKWLARAGDGLVYAYEEALGHCVDPSRVRDKDGISAAVLAADLVARLKSEGRTLIDELADYAVEFGLHATGQVALRLADPAAAAAVVAQLRAAAPGEIAGEPVKYTDLAQARGRMRTDALIFDGTNTRIVIRPSGTEPKLKCYLEVVEPVAGRAALPQAEAAAAQSLSRLREFCAALADGPARRG
>NZ_CP046172.1|WP_167472351.1|1485733_1486075_-|hypothetical-protein
MRKSLWLTGFGVAAVLASAGPAAAAPTIMDHDGTYVVGTDITPGDYVTYSATGSCVWARLTSYGDVLESGNGGSGTQRIRIAAGDGAFSSTGCGVWRTENANRTGSGTGSAGS
>NZ_CP046172.1|WP_167472350.1|1484888_1485512_+|uracil-phosphoribosyltransferase
MRTDTVAHPLAAALLTTMRDARTDNPAFRAALRDLTGILVYEALREAPVTRFEVTTPVAVTEGVRLAAPPLLVPVLRAGLGMVDAAAELIPDARVGFVGIARDERTHQPVPYMESLPDDLTDLPVFVLDPMLATGGSMRHTLELLAARGATDITAVCVVAAPEGIAALEKSGLPVRLVTATVDAGLNENAYIVPGLGDAGDRQFGPR
>NZ_CP046172.1|WP_167472359.1|1497127_1498303_+|PLP-dependent-aminotransferase-family-protein
MSPTIPSLAGKLGGLQSSAIRDLLKLTVRPDIIGLAGGLPDAELMPRERIAVAADAALRDSACLQYTESPGWAPLRAVLAERESARLGRTVGLSEVFVTHGSQQALSLLAEVLLDPGALVIVEDPAYVGALQVFRAAGARIVAVPLDREGMRIDALTELLERGERPALVHTVSNFHNPGGVTMAEHRRRELAELAQRYGFWVIEDDPYGELWFDRPAPAPIASYSHNVIRLSSASKILSPALRVGWLVAPDAVCRGVELLKQGADLCGSALTHQITADLLADESWLAGHVDSVRTAYGARAKALVHAFRATFGDRASCTDAAGGMFVWADFTDGTDTADLLPRALEHGVAYVPGSAFAVDGGYRNSLRMCFTTSDEATLTEAIDRMARAVG
>NZ_CP046172.1|WP_167472360.1|1498459_1499959_-|glycerol-kinase-GlpK
MRRYVAAIDQGTTSSRCIVFDRRGHVVGVAQREHEQIFPRPGWVEHDPESIWRNTESVLGEVLERAGVRADEIAAVGVTNQRETTVVWDRKSGKPIHNAIVWQDTRTDRLAIELGGEYGPNRYQERTGLPLSTYFAGPKLRWILDHVDGAKERAEAGELCFGTMDSWVLWNLTGQHITDVTNASRTMLMNLRTLQWDSELCAEFGVPSSILPQIRSSSEVYAEINSGPLAGIPVAGILGDQQAATFGQACLTPGEAKNTYGTGNFMLLNTGTTPVPSNHGLLTTVCYRLGQEPAVYALEGSIAVTGSLVQWFRDNLGIIGSADEIEPLASSVADNGGAYIVPAFSGLFAPRWRPDARGVIAGLTRFVNKAHLARAVLESTAFQTREVVDAMRADAESQHLGLELTTLKVDGGMVGNELLMQFQSDILDVPVVRPVVNETTALGAAYAAGLAVGYWSGTDDIRANWTADKTWEPTMSEADRYNYLVAWNKAVERTYNWVD
>NZ_CP046172.1|WP_167472361.1|1500112_1501846_+|glycerol-3-phosphate-dehydrogenase
MTKKPESQALGPEQRRAAWERFGKDHFDVVVIGGGVVGAGIALDAATRGLQVALVEARDLASGTSSRSSKMFHGGLRYLEQLEFGLVREALRERELALSMLAPHLVKPLRFLYPLTHRVWERPYVASGLVLYDTMGGAKSVPGQHHLSRHGALRLAPGLKRSALIGGVTYYDTVVDDARHTMTVARTAAHYGAVIRTSTQVVGFLREADRVVGVKIRDSEDGRTGEVRAHVVINATGVWTDEVQALSNNRGRFHVRASKGVHIVVPRDRIVSDAAIILRTPTSVLFVIPWGAHWIIGTTDTDWNLDLAHPAATKADIDYLLDRVNQVLVTPLTHDDIDGVYAGLRPLLAGESDETSKLSREHAVARVAPGLVGIAGGKYTTYRVMAYDAMDEAAQDIPARVSPSITEKVPLLGADGYFALVNQTVQLAEAYGVHPYRIKHLLDRYGSLIDEVMAMAAGKPELLQPITDAPSYLQVEVVYAAAAEGALHLDDILARRTRISIEYSHRGSHCAEQVAQLVAPVLGWDEDEIDREVRTYQARVDAEVRSQTQPDDASADALRIAAPEPRPEILEPVRAEG
>NZ_CP046172.1|WP_167472362.1|1501849_1503094_-|HAMP-domain-containing-histidine-kinase
MARLRRTRWQLTALITTIAALSLIILGAVAATIDARSRDQAVDDALDRVVAGVQRALVLQDDTIDASALQGDDLANGEMAVMVLTDTSDGKWKTVYEHLNSWLPKKDGIKALADDISVPGTAGTHFKSSTDSVGRPVRLAVSPVSWPDSQVQAAIIVGTNPGAHDRDRALLLWGLIVGGLVLVTLAAIAAHLLSGRSIRQAVVMVDEQERFLGDAAHELRTPLATLRLVSEPRRRNPHELERALADARALGDRMERIVAGLLARARMQAGVTTMERVQLLLDQLTESVADEFTGKNVVVQANPSVIVGDPALLSLAIRNLIENAITHGAVNPHAPVEVYVAEGRVSVRDHGAGLNPQLSSNPFQRGVTSGRGSGIGLSLVAWIAELHGGTATMEPAPGGGTIATITLPPPGLGG
>NZ_CP046172.1|WP_167472363.1|1503135_1503795_-|response-regulator-transcription-factor
MRVLVVEDDEGLGNEVAAGLRSAGFAVDLAHHLADADLKISVNTYDCLVVDRGLPDGDGLQLVAAKRQAGQRVPVLMLTARDGLADRIAGFEHGADDYLVKPFALAELAARVRALCRRREQPAPSRLVLGDIDIDLPRRRVMRAGILRSLTPKEFAVLELLAARAGSVVSRTELIECCWDEMAEPASNVVDAVIAQLRRKLGAPPVIETIRGTGFMIGT
>NZ_CP046172.1|WP_167472364.1|1503889_1504096_-|hypothetical-protein
MQLKSAIAASALAVAALAAGTGIAHADYIGNYATLEACQADGNSPKTGGTQWECRYAQDGVSFDLYTY
>NZ_CP046172.1|WP_167479022.1|1504191_1504764_-|helix-turn-helix-transcriptional-regulator
MSATDRRAQLLDVARDIVGADGFGAVTIERVAREADVARALVYQQFTDLNGLMTALLDRETSIALSGVSSVDWAADTIDQVAEGILAYLHAAPTSWQIMLSPPDGGPPNLRARLELGRSYARAVGARHLSRFAGVEVDPNGPTERILLAALEELARLHLDNPQRYPDEVVLHYIRELVGWAAGAEARRPR
>NZ_CP046172.1|WP_167472365.1|1504811_1506173_-|FAD-dependent-oxidoreductase
MNDSRQYVVIGGGLAGLAAAVWLAEAGKRVTLLERRGRLGGRTHAMTVDAVDDPPDNGQHVIASGYDHLFRYLSTIGTRQYVKFPHQGTLRWPGGRAVIMHTKGLGALRTLSGAHPDASPVERARALLATLRLGWQCLRQPADLADLTTEQWFQRIGMPAKAREALWDWLALGVAAEPVRQESAKVLADVMATGIRLGVKHRRPATIGYPTTDLDTLYITGALRYFEKHGVEVRYRAVARRIQIADGRVTGVVLADGSVLPADAVVCAVPNSAVGGLLDDLPEHAELYAAADKLGYTPIVSTNLYLDRPLGTKSEFEALIGGTGVIDEVFDRQRMTGRDTERAWLYCLTTSGAYEQIHKSNEEIVTEQVELLRRYYPAAHDAKVVAAQVVKMPRATFSQVVGTHGLRPDQRTSVPTLVLAGDWTATDWSATMESAVQSAARAVELLLALPSHS
>NZ_CP046172.1|WP_167472366.1|1506315_1506456_-|hypothetical-protein
MLLAIAARLLAAAFAAAITAVFGYLLLHQDSPEHRNTTPPSLSVHP
>NZ_CP046172.1|WP_167472367.1|1506667_1507240_+|dihydrofolate-reductase-family-protein
MRTLISTAFISLDGVMEAPGGEPGYRNSGWTFKNIEFVPEAYEIKQREQDESTAILLGRVSYQAFSPVWPKMAEFSGYKAMPKYVVSTTLTDQDLVADWGQTTILRTLDEVAALKQTEGGPIIVHGSAALNHGLADAGLIDRYHLLVFPLLLGAGKRLFPATDKDAQKLKLVESEVYSNGLQKNVFDVVH

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Crispr_ID: NZ_CP046172_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046172_4

1784701-1784790

Orphan

Consensus_repeat	Method
GCGCACGGCCGGAGCGACTGCGGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046172_4

>merge|NZ_CP046172|4|1784701-1784790|CRISPRCasFinder
GCGCACGGCCGGAGCGACTGCGGAGATACGCCTGATGCCGCTGTGGGCGAGGACGTCCTCAGTCCGCGCACGGCCGGAGCGAATGCGGAG

>NZ_CP046172|4|4|1784701-1784790|CRISPRCasFinder
GCGCACGGCCGGAGCGACTGCGGAG	ATACGCCTGATGCCGCTGTGGGCGAGGACGTCCTCAGTCC
GCGCACGGCCGGAGCGAATGCGGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046172.1\|WP_167472577.1\|1772878_1773928_+\|mammalian-cell-entry-protein	unknown	unknown	gnl\|CDD\|224380
NZ_CP046172.1\|WP_167479059.1\|1790730_1791096_+\|DUF4345-domain-containing-protein	unknown	unknown	gnl\|CDD\|372978
NZ_CP046172.1\|WP_167472587.1\|1786890_1788126_-\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|235874
NZ_CP046172.1\|WP_167479056.1\|1779336_1780842_+\|histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP046172.1\|WP_167479058.1\|1789879_1790644_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP046172.1\|WP_167472578.1\|1773924_1774929_+\|MCE-family-protein	unknown	unknown	gnl\|CDD\|273384
NZ_CP046172.1\|WP_167472585.1\|1784809_1785670_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378976
NZ_CP046172.1\|WP_167479055.1\|1774925_1775951_+\|MCE-family-protein	unknown	unknown	gnl\|CDD\|273384
NZ_CP046172.1\|WP_167472590.1\|1791163_1791793_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167472589.1\|1788722_1789868_-\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP046172.1\|WP_167472580.1\|1777050_1778097_+\|MCE-family-protein	unknown	unknown	gnl\|CDD\|273384
NZ_CP046172.1\|WP_167472584.1\|1783783_1784629_-\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187578
NZ_CP046172.1\|WP_167472579.1\|1775950_1777054_+\|MCE-family-protein	unknown	unknown	gnl\|CDD\|273384
NZ_CP046172.1\|WP_167472583.1\|1782586_1783750_-\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP046172.1\|WP_167472586.1\|1785739_1786108_+\|ADP-ribosylation/crystallin-J1	unknown	unknown	unknown
NZ_CP046172.1\|WP_167472588.1\|1788207_1788678_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP046172.1\|WP_167472581.1\|1778093_1779050_+\|MCE-family-protein	unknown	unknown	gnl\|CDD\|224380
NZ_CP046172.1\|WP_167479057.1\|1786108_1786837_-\|VIT-family-protein	unknown	unknown	gnl\|CDD\|153123
NZ_CP046172.1\|WP_167472582.1\|1781570_1782584_+\|DUF418-domain-containing-protein	unknown	unknown	gnl\|CDD\|225193
NZ_CP046172.1\|WP_167472591.1\|1792196_1795085_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276938

Protein	Function_ID	Function_description	E-value
NZ_CP046172.1\|WP_167472577.1\|1772878_1773928_+\|mammalian-cell-entry-protein	gnl\|CDD\|224380	COG1463, Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism].	1.52854e-09
NZ_CP046172.1\|WP_167479059.1\|1790730_1791096_+\|DUF4345-domain-containing-protein	gnl\|CDD\|372978	pfam14248, DUF4345, Domain of unknown function (DUF4345). This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 125 and 141 amino acids in length. There is a single completely conserved residue E that may be functionally important.	6.50365e-08
NZ_CP046172.1\|WP_167472587.1\|1786890_1788126_-\|FAD-dependent-monooxygenase	gnl\|CDD\|235874	PRK06847, PRK06847, hypothetical protein; Provisional.	1.05567e-43
NZ_CP046172.1\|WP_167479056.1\|1779336_1780842_+\|histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	3.05992e-28
NZ_CP046172.1\|WP_167479058.1\|1789879_1790644_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.10395e-15
NZ_CP046172.1\|WP_167472578.1\|1773924_1774929_+\|MCE-family-protein	gnl\|CDD\|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	7.10558e-34
NZ_CP046172.1\|WP_167472585.1\|1784809_1785670_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|378976	pfam12852, Cupin_6, Cupin. This is a family of bacterial and eukaryotic proteins that belong to the Cupin superfamily. Some of the proteins in this family are annotated as being members of the AraC family of transcription factors, in which case this domain corresponds to the ligand binding domain.	9.35754e-38
NZ_CP046172.1\|WP_167479055.1\|1774925_1775951_+\|MCE-family-protein	gnl\|CDD\|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	1.66164e-32
NZ_CP046172.1\|WP_167472589.1\|1788722_1789868_-\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	1.74948e-49
NZ_CP046172.1\|WP_167472580.1\|1777050_1778097_+\|MCE-family-protein	gnl\|CDD\|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	4.69922e-25
NZ_CP046172.1\|WP_167472584.1\|1783783_1784629_-\|NAD(P)H-binding-protein	gnl\|CDD\|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.36087e-59
NZ_CP046172.1\|WP_167472579.1\|1775950_1777054_+\|MCE-family-protein	gnl\|CDD\|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	1.24177e-18
NZ_CP046172.1\|WP_167472583.1\|1782586_1783750_-\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	1.28512e-50
NZ_CP046172.1\|WP_167472588.1\|1788207_1788678_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.1509e-14
NZ_CP046172.1\|WP_167472581.1\|1778093_1779050_+\|MCE-family-protein	gnl\|CDD\|224380	COG1463, Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism].	3.46555e-26
NZ_CP046172.1\|WP_167479057.1\|1786108_1786837_-\|VIT-family-protein	gnl\|CDD\|153123	cd02432, Nodulin-21_like_1, Nodulin-21 and CCC1-related protein family. Nodulin-21_like_1: This is a family of proteins closely related to nodulin-21, a plant nodule-specific protein that may be involved in symbiotic nitrogen fixation. This family is also related to CCC1, a yeast vacuole transmembrane protein that functions as an iron and manganese transporter. .	1.17152e-106
NZ_CP046172.1\|WP_167472582.1\|1781570_1782584_+\|DUF418-domain-containing-protein	gnl\|CDD\|225193	COG2311, COG2311, Predicted membrane protein [Function unknown].	2.66289e-40
NZ_CP046172.1\|WP_167472591.1\|1792196_1795085_-\|hypothetical-protein	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	7.58352e-36

>NZ_CP046172.1|WP_167472584.1|1783783_1784629_-|NAD(P)H-binding-protein
MVRRRPPRLTRSMTILVLGATGKTGRRVVGRLRDEGEKVLAASRSGEVRFDWSEPDSWTAPLAEADAVYLIAPDDPAPVSPFVARAVASGVRRLVVLSGRGIEHTGGRFGHGMSAAEDAVRAAGVDWTIIRANNFDQNFDEDLWHAPLLAGRLALPIGAVGESFIDAEDVADVAAALLTRDGHAGQIYELSGPRAITFAEAVAAIAAASGRTIEYAELTPQAYEDELLAAGYPAAVATELGVMFELMRTGTNTPPTDGVQRVLGRPARDFESYVDRVWHRK
>NZ_CP046172.1|WP_167472583.1|1782586_1783750_-|cytochrome-P450
MIEVFDTGFAADPWATLDRLRADGGVHRVRTPDGPPAWLVTRYSQVRAGLLDERLTTHVRHANSDDYRGFALPPQLETSLANAAPADHARLRRIVTGELSPRRLAEWTTLAPRLVEPILRELNTDDEVDLVERLAVPLPAAVLGELLGLTEPAREALAVWANSTLMPSAEPPRARDTLDVMLSVIATTKERPRDDTVLGRLVAAHRAGHLDDDELTGLLFYLLFVWYEVLVDLVAGGILTLLDRADQRSLLGDPMNSHRAVDELLRYLSPQVLTGPRFALTDLTIGTHTIKAGQTVLLCLASANHDPEIFDAPSELDLARTRNPHLGLGYGTHACLGTALVHTVTATTIDQVFTRWPGIALTVAESTLGWRSGFRHRGPLTLPVRLA
>NZ_CP046172.1|WP_167472582.1|1781570_1782584_+|DUF418-domain-containing-protein
MRYRLAARPRIHELDAVRGFALCGILVVNIWQLTGMRETKAPGVLDQRRQVLSLLFEGRFFPIFSFLFGLSFALFLERAADRTDRPRVVLARRLIALAGFGLIHHIFQPGEALLPYAIVGLMILLPATALPRWVVLLAGLSGTIAVPLLLGGGFGLVPGLFLLGLAAARFDVVPNLNRRSWLVPLIFVVAAPAAVVAGIWQYRTPLLDLGSPAPAIAGLIGALAYLTGLLLLLRTEFGELLSDLLEPLGRMALTNYLSATALVLTAERYLRLHDSTRYGMLLALAAAIILVQTVFSYWWLRWFRYGPLEWIWRCLTWWQLVPNRLTRDERRRLAQRW
>NZ_CP046172.1|WP_167479056.1|1779336_1780842_+|histidine-kinase
MLRPDNEPPKAPAWPIPTGVTVSPTVRPTSPPPRSPRRSPRRPRSCRRYPQAESATIARTTESSRNGICATANWSACHRNRANRLSRYCPFVRPDISSDGRNRRCRWPGIIGRVFDSGVTRGVDWLLDARSLAVRTGVLLLLAVGCLALLSKDAGPVDWGIGLVAVLVTAGGVRWPLTTALAESGLLVLGFTVGHAGPLVVKVGAGIALTELAARRGGWPPLLAAAALAGAYLLHGGEFAADGYRALVMAGFPLLIGGLLRTARESADRARQAADELAQRREADIAAARAVERTAIARELHDLIAHHVSSTVLRVGVARHAVPDTPPAVRAVLDDIHASGTETLADLRLLVSVLRDPAMTGESFTAPADLPAALSVITDRAQQLGHTVDASIDDAVTGTDALRALTLLRLTQEGMTNLVKYAPDAVARLSIAVAPDGSIDFSLCDNGIRSRRAASAVAGGGLGLIGLRERVELLGGEFDAGPTDSGWRLAARLPAPVRGAA
>NZ_CP046172.1|WP_167472581.1|1778093_1779050_+|MCE-family-protein
MKVGSLASLGGIAAITVLGAGYLTFGVVRADPFAEYTNASMVLRDSGGLGAGSPILLTGIPVGKVTAVDNTASGVEVRFRVKREQRLPTDSTITIEQLSALGEPYVQFVPKGDGGPYLQDGQRLDTKSVTAPLSIPEVARLVTKTMNQLDPKVVGSLVDTMGRAISGTEATMPQLARSGDLLASTIMSRAPKIAELFNSFQQAAGDIDWAGPATSDAAPNLVQFEKSLAALVEAVGRLVNTPGNPDVYLQGNGLAPFLAKVTEWLNKVGPDIKEMLPGLRPLTDAITATGPQLDISALISQALQQTGDDAVKVRITVK
>NZ_CP046172.1|WP_167472580.1|1777050_1778097_+|MCE-family-protein
MRRNPLRRTVLALAATVGLAVGGCAFDPSSVPVPGTDVSGPTYPIKIEFANALNLPAKAKVIANGAQVGTVEKVTVVPSSQARGGYVVVDADISSSVRLPTNTVAELRQNTVLGDIHIALTTPSDGFGSLLAPGGTIGIDRTKPPVQLEDTMAALAFFVQGGAVGQIQDIMTRFNAVLPKDPKDTARISGVMGADAADLAANLDQVDKLIDGLATNAEVLHDIRPELDRILRPESVQQVTGAVQSIQGVTKVFGALGPVGDSLAWLAPLLQSQDAALQALVPLLTGGQLDLRQPSNLAMLVALLRDKIIPFAEHGPKVNLTGATVNSMPEQDQIDRIIKTLRMIGAVR
>NZ_CP046172.1|WP_167472579.1|1775950_1777054_+|MCE-family-protein
MLKRVLGSRAFMSIAGAVVVAAVAVAGYFIVFDPLKETRSYCAVMSDSIGLYPGNQVTMRGIVVGSVTSVRNEGKQVRVDFDVDAKYPVYADAAATTVSDTVVADRNLAVLNSGKDLRRWDGAQCITNTLTPKSLTETLTALAQLADQLNGPGAAQQNSLSNGLAALDAATSGTGPQFNELVRKLGSALQSPDADIAHLAGIFDTFSSVSKKVNEHWGDLRSMLTRMGPALNQASTELLGPGAELFDALRQVLPVLNDITTMFGDTILKGLDATVPLIKLLRANVGSLRDIVLMTPVLTNAFQSVTDTSTGAPGITYAPPRVRIPAQNAEQVCAAVNAVTPGRCAGAGDGMVDVELVQLVLGLAGAR
>NZ_CP046172.1|WP_167479055.1|1774925_1775951_+|MCE-family-protein
MTKWRNWFGGDRPVTDEPTRLRREVRLGVVGAVLVVIALAAAAVLYVVPFGKTTYTAELSEAQSVRAGDDIRLAGITVGSVKSLELKPDRVIMKFTVDSDVFVGDESSLDVRMLTVVGGHYVALFPAGAKPLGGKVIPADRVRLPYSLVQTFQDATTPLNQIDGSTLRKNLATLDSSLAKAPESLRTTLDTLGGYVDAINRQRTQVSNAVAVADEYISLYDGAKTDLGRLMDNSNLLETVLLDKRAELRESIALLTSVLQRVAALAPTWDDKLKPLAQQLADALPRLEQLGQQLQPMIDSVHGLQAKVRQWLPDGGVVVDQSGQTVQAPAGVCVPLPGKAC
>NZ_CP046172.1|WP_167472578.1|1773924_1774929_+|MCE-family-protein
MTVRGAAWRLGLFAAVMMVVLALVLTAIKRPVAGDTEAHDAIFTDANGLKVGDDVRMYGVQVGKVEGISLEGDKAKVRLTVKTATPIYDNSTLAIRYQNLTGQRYIDLQQQPNPGVRLAANARIDAKMTLPSFDVTSLFNGLKPVLATMSPETVNQFTESMLAVLQGDGNGLGPALDAIGKLSKYASDRQAVIGTVVRNMSDLADKVGGRVHYLVPLLARLTDIFQALQQNIGGLAEFAMSAPSVLGPVDRLLSTIGLTKDSGQDLDALIRSLFPDPKQAVEVFGRLPGLLSAIDASLPRTVAGWQPECSKGTMQAPAPLRMLIAGQQVTLCNG
>NZ_CP046172.1|WP_167472577.1|1772878_1773928_+|mammalian-cell-entry-protein
MPKYGLPGVAADRRRARTVGGLIVALVAAVAVATVVYRDMRGADGLRIALHTEQIGDGVAEGTQVRLDGVLVGKVARIAPDVLGTQRITLQLDSSRLFGIDDSLRVDYAPANLFGISELELRRGPGGSPLRADQVIDLTGRRAADVYDATMGSILRSLSQVGASVLTPQMVQVIAQVSSDVQAFTPLVQALITVARTIADNQTMKPSELAGELGPAFDGGGRFAGSVIQALDGINDINVLKGDRAHYDSGVAAMTGQILPGLATTGNTAGKYFGDGADTLAPVLRVLAQMVPRPQQSAAELRELLTRLRAAMPDTPDGPVLNVEADLRGVPGLSVPLLGLGAPIPGGAR
>NZ_CP046172.1|WP_167472585.1|1784809_1785670_+|AraC-family-transcriptional-regulator
MDPFDDLLRSVRAEGAIFGKPVLSAPFALRFTDGAALTLCVPLRGSGWLVTADQRQRIEVGEVAIVRGPDPFVFTDDPDRGDEPTDIAGWSAEQPTGDTVLLAGTYQVRRAVPARLLRVLPPLLTVPDGEDCAPLREYLEGQLVGGHPGRQIVLDRLLDWLLVCTLRDWFDATAPAWYQALSDPVIGPVLRAMHETPGAPWTLATLATEAGVSRTTLAKRFAETVGEPPLAYLTDWRMTVAADLLAEPGATVSSVARRVGYADAFGFSSAFKRVRGVSPSAYLRSA
>NZ_CP046172.1|WP_167472586.1|1785739_1786108_+|ADP-ribosylation/crystallin-J1
MEQNAVTVLWRPTGPAELALVAGTGWRAWPPRLPDQPIFYPVLSEDYAVMIARDWNVPASGAGYVTRFSVETNYLARYEVQQVGGREILEYWIPAEELDEFNAHIIGKIEVVHCFPDDAPLP
>NZ_CP046172.1|WP_167479057.1|1786108_1786837_-|VIT-family-protein
MRQVNEPTGAHPHEPHGEGLASRLNWLRAGVLGANDGIVSTAGLVVGVAAATTSTNAIFTAGIAGLSAGAISMAVGEYVSVSTQRDSERALLAKERRELRDEPGYELTELAGIYRDKGLSAETARKVAEELTAHDAFTAHAEAELGLNPNELTNPWQAAFSSAVSFTLGALLPLLAILLPPVTARIPVTFAAVLIALAITGSLSARLGGSSRGRAVLRVVIGGALAMAVTYGIGQLAGISGI
>NZ_CP046172.1|WP_167472587.1|1786890_1788126_-|FAD-dependent-monooxygenase
MKKALIIGGGIAGPVTAMALQKAGLEPVIYEAYHEVAGEQLGAYLTVAVNGLQALSQIDVDPVVTGVGHPTDTLSFFTSANKHIADVPVGGTLPDGTVTHSVKRRDLYRALTDEAVRRGIRFEFDKRMVDARPTPDGGVLVTFADGSSATADLLIGADGIRSRTREIIDPTAPKAHFLGIYGLGGFVTDRTLYKKFGLRIGDYNMVVGKQTFFGYHVAPDGEIWWFTNIPATKELSREELAASRPGDWRERLVELVGVDDTPAARIVAATGDETFVPAFNQYDMPSVQKWHNDNMVIVGDAAHAVASSSGQGVSLAVEDAVVLAQCLRDIPDTAKALAAFEASRRERVERIVRHGAATSAARSSTNAVGRWVFRQLMPIFLRKAAKQGIGSIQWMYQHRVHWDETPVPASR
>NZ_CP046172.1|WP_167472588.1|1788207_1788678_+|MarR-family-transcriptional-regulator
MSRENLDELRARVGLESQAFQAAVDDFDQAVATTLGVNRTDLRCLEVLMRGGATPGALAAELRLTSGSVTTMLDRLAKLDYIARHPEPGDRRKVLVKITPHTQNRLWEMYGPIVEEGQRELAKYTAAELKTIIAFLSGSRELQERQRGRIAGLASD
>NZ_CP046172.1|WP_167472589.1|1788722_1789868_-|cytochrome-P450
MTIGTAARGRHAEHETFRGGVRKAELPGGQEVWVVSGYDEVAGLLADSRLSLDKRNSGGGYTGFGLPAALDRNLLNMDGDTHGRVRRLAAPAFSRRSAESLRSAVNRITASVFEALPDKDSDAVDLMEKLCTPVPALVIAELLGAPSDLYAGMREVANAMMTFDARSKSSGQRLMAAIGWCTTTITELVAAKREQSGDDLLSSWIRARDDEDRLSEDELVSLAFLLLLAGLENAALLTGELIAALLETEDRRTIIADWPNRRAELIERHNPLPFAIRRFAVTDLTFGEHTIPKGGTVLLSLFGADSDPARNGRPSLMFGRGPHYCLGAQVTDLIVDAVVPAFCTRYPDARLAIPAADLVYRESWRSHGLAELPVRLSAQPI
>NZ_CP046172.1|WP_167479058.1|1789879_1790644_-|helix-turn-helix-transcriptional-regulator
MWIWPGHALYAGPALDLAPHSGSVWCLAVGVDGPITVRGAGEEQTVRSALIPPRLTHQLVCHGGRMVFCYLDPSSDHAESVIRQMVRQHAKIGAQHGREALLIAGARALCTHGSDAAAGRWLELAAPTTARHIDPRIDEVIRRIRERPADTASARELAAGVALSESRFLHLFRAATGTSLRRYRLWHRFLFAATYLTDGQTLTAAAAAAGFASPSHLADRFRATFGLAATQLLGTGVTLRPLGSEVLCRDEWER
>NZ_CP046172.1|WP_167479059.1|1790730_1791096_+|DUF4345-domain-containing-protein
MAVIAVVGLSFLAMGIHAIAAPAMLVRPFGIRLDQAVSRAEVRAVYGGFGFAMAAVLALAAFHPGSLRTGITVTVAAALGGMAFGRLLSALLGDRTPFYPNWFYCAVESIAAAALLLTDYR
>NZ_CP046172.1|WP_167472590.1|1791163_1791793_-|hypothetical-protein
MARTPRTRLRIGAVLVVIAAVEAAVFEGWILRDLLMTATFALNAAVVVVLLWGLIAEFDAAAAAPIRRFIGCALTLGLCTVIVLTNAIIVLATKGERASTPSSREFLPVPSELTVRTDENGGCGGGSATICLRRFEIQGASGAPTAEVVDTVRHHLDTNHGWSLTFDPRRKTWSECRDNGWALDRNRLCASVFTHDGLVVVEFEEWADN
>NZ_CP046172.1|WP_167472591.1|1792196_1795085_-|hypothetical-protein
MRFVVLGEVQGWRGEAPLDLGPPQRRAVLAVLLLRVGKAVAAAELVEAIWGDQPVPRAIAALRTHVAQLRRALEPDRAARGRSTLLVSVGDGYALRIPPESIDVAEVERLVTAAQRLRPSDPAAARDALVAALSAWRGPALSGLPGPFAERQRSRLEQWRLAILEDRLALDIEIGRDAEAVTELGPLIEVYPLRERFRALLMTALYHSGRQAEALDAYAHARRALVEGIGVEPGPELTAVHEKILRAEMPAPGTPSRQAEPPPAQLPPDIADFTGRGDIVEALAAQLTNDGGAVAISAVGGMGGVGKTALALHVAHNIRDHFPDGQLYVNLHGVDPVPTPPGDAVGGFLRALGVPEGDIPPSVDERAALLRTRLSGKRMLLLLDNARDSAQLAPLLAGTPGTAVLITSRSALTELPAVRRTRLDVLAADEALTLLTRILGAQRVAAEADAARAMVAHCGYLPLAVRIVGARLAVRPRWTIESFATRLADERGRLALLRTGELGVEAAFRLGYGQLNAKQAKAFRTLALAEVPDLPVEGVAAMLGVAVDEAEQVCESLVDLSLLETTTPGRYRFHDLLRLFAREVADEDESDVVVRLLGYYLASVKNLLGVIDFSNTTRLLVPTAVPGRAFTDGSYGQAWNDTERPVVIALHKQAARIGGQALAVAADLAWVMAELMDVGTAARELAGALESLLDAAVRAGNPATERRIRVALGAILQVGLGEVAASLRHLRGVARLPVRDDADRRLSVLTDILLAIAERRLGNIDASRAHFADALRLAGVLGDRSMTALLLALVTRTHCEAGQYDDAMATAEQAIALARETSNPVALGWALHEYAATMSMRGEHVRAVELGNEAVRTAQRNGVRLWEGWARTRLAQVYLQAGELTKAEEQADAALRLLAKAADPIDRARAMALRAIVLSRRGLIGPAEREFREAAEIFQRAGLTPPTIGSLFSAGSPASTPE

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Crispr_ID: NZ_CP046172_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046172_5

2576528-2576598

Orphan

Consensus_repeat	Method
GCTGAAGATGTGGGCGGCGGTTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046172_5

>merge|NZ_CP046172|5|2576528-2576598|CRISPRCasFinder
GCTGAAGATGTGGGCGGCGGTTCGTCCTCGGACCGGGCCGCTTCCTCTGCTGAAGGTGTGGGCGGCGGTTC

>NZ_CP046172|5|5|2576528-2576598|CRISPRCasFinder
GCTGAAGATGTGGGCGGCGGTTC	GTCCTCGGACCGGGCCGCTTCCTCT
GCTGAAGGTGTGGGCGGCGGTTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046172.1\|WP_167473160.1\|2581992_2582517_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167473157.1\|2575239_2576508_+\|triacylglycerol-lipase	unknown	unknown	gnl\|CDD\|367570
NZ_CP046172.1\|WP_167473158.1\|2579493_2580345_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|237571
NZ_CP046172.1\|WP_167473164.1\|2586061_2586511_+\|PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274679
NZ_CP046172.1\|WP_167473150.1\|2568842_2569154_-\|AzlD-domain-containing-protein	unknown	unknown	gnl\|CDD\|377512
NZ_CP046172.1\|WP_167473151.1\|2569150_2569855_-\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224215
NZ_CP046172.1\|WP_167473154.1\|2571992_2572397_+\|globin	unknown	unknown	gnl\|CDD\|381280
NZ_CP046172.1\|WP_167473152.1\|2569934_2570552_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP046172.1\|WP_167473156.1\|2574571_2575036_+\|DUF5130-domain-containing-protein	unknown	unknown	gnl\|CDD\|379937
NZ_CP046172.1\|WP_167473153.1\|2570555_2570867_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167473159.1\|2580466_2580973_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|226604
NZ_CP046172.1\|WP_167479122.1\|2581051_2581675_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167479120.1\|2572650_2574237_+\|glycoside-hydrolase-family-13-protein	unknown	unknown	gnl\|CDD\|200471
NZ_CP046172.1\|WP_167479123.1\|2584584_2585853_-\|IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NZ_CP046172.1\|WP_167479119.1\|2570908_2571421_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|224321
NZ_CP046172.1\|WP_167479121.1\|2576679_2579250_-\|aminopeptidase-N	unknown	unknown	gnl\|CDD\|274121
NZ_CP046172.1\|WP_167473163.1\|2584261_2584504_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167473161.1\|2582855_2583173_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|197648
NZ_CP046172.1\|WP_167473162.1\|2583314_2584076_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP046172.1\|WP_167473155.1\|2574306_2574585_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP046172.1\|WP_167473157.1\|2575239_2576508_+\|triacylglycerol-lipase	gnl\|CDD\|367570	pfam03583, LIP, Secretory lipase. These lipases are expressed and secreted during the infection cycle of these pathogens. In particular, C. albicans has a large number of different lipases, possibly reflecting broad lipolytic activity, which may contribute to the persistence and virulence of C. albicans in human tissue.	7.65111e-37
NZ_CP046172.1\|WP_167473158.1\|2579493_2580345_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|237571	PRK13961, PRK13961, phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional.	1.61589e-170
NZ_CP046172.1\|WP_167473164.1\|2586061_2586511_+\|PPOX-class-F420-dependent-oxidoreductase	gnl\|CDD\|274679	TIGR03618, Rv1155_F420, PPOX class probable F420-dependent enzyme. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity].	9.45544e-28
NZ_CP046172.1\|WP_167473150.1\|2568842_2569154_-\|AzlD-domain-containing-protein	gnl\|CDD\|377512	pfam05437, AzlD, Branched-chain amino acid transport protein (AzlD). This family consists of a number of bacterial and archaeal branched-chain amino acid transport proteins. AzlD is known to be involved in conferring resistance to 4-azaleucine although its exact role is uncertain.	3.34711e-05
NZ_CP046172.1\|WP_167473151.1\|2569150_2569855_-\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|224215	COG1296, AzlC, Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism].	2.37097e-41
NZ_CP046172.1\|WP_167473152.1\|2569934_2570552_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	3.44967e-15
NZ_CP046172.1\|WP_167473161.1\|2582855_2583173_+\|hypothetical-protein	gnl\|CDD\|197648	smart00316, S1, Ribosomal protein S1-like RNA-binding domain.	0.000281213
NZ_CP046172.1\|WP_167473156.1\|2574571_2575036_+\|DUF5130-domain-containing-protein	gnl\|CDD\|379937	pfam17174, DUF5130, Domain of unknown function (DUF5130).	8.5273e-72
NZ_CP046172.1\|WP_167473159.1\|2580466_2580973_-\|NUDIX-domain-containing-protein	gnl\|CDD\|226604	COG4119, COG4119, Predicted NTP pyrophosphohydrolase [DNA replication, recombination, and repair / General function prediction only].	3.19706e-49
NZ_CP046172.1\|WP_167479120.1\|2572650_2574237_+\|glycoside-hydrolase-family-13-protein	gnl\|CDD\|200471	cd11332, AmyAc_OligoGlu_TS, Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins. Oligo-1,6-glucosidase (EC 3.2.1.10) hydrolyzes the alpha-1,6-glucosidic linkage of isomaltooligosaccharides, pannose, and dextran. Unlike alpha-1,4-glucosidases (EC 3.2.1.20), it fails to hydrolyze the alpha-1,4-glucosidic bonds of maltosaccharides. Trehalose synthase (EC 5.4.99.16) catalyzes the isomerization of maltose to produce trehalulose. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NZ_CP046172.1\|WP_167479123.1\|2584584_2585853_-\|IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	7.54473e-142
NZ_CP046172.1\|WP_167479119.1\|2570908_2571421_-\|HNH-endonuclease	gnl\|CDD\|224321	COG1403, McrA, Restriction endonuclease [Defense mechanisms].	2.28066e-23
NZ_CP046172.1\|WP_167479121.1\|2576679_2579250_-\|aminopeptidase-N	gnl\|CDD\|274121	TIGR02412, Aminopeptidase_N, aminopeptidase N, Streptomyces lividans type. This family is a subset of the members of the zinc metallopeptidase family M1 (pfam01433), with a single member characterized in Streptomyces lividans 66 and designated aminopeptidase N. The spectrum of activity may differ somewhat from the aminopeptidase N clade of E. coli and most other Proteobacteria, well separated phylogenetically within the M1 family. The M1 family also includes leukotriene A-4 hydrolase/aminopeptidase (with a bifunctional active site).	0
NZ_CP046172.1\|WP_167473154.1\|2571992_2572397_+\|globin	gnl\|CDD\|381280	cd14771, TrHb2_Mt-trHbO-like_O, Truncated hemoglobins, group 2 (O); Mycobacterium tuberculosis hemoglobin O like. The M- and S families exhibit the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments. Truncated hemoglobins (TrHbs, 2/2Hb, or 2/2 globins) or the T family globins adopt a 2-on-2 alpha-helical sandwich structure, resulting from extensive and complex modifications of the canonical 3-on-3 alpha-helical sandwich that are distributed throughout the whole protein molecule. TrHbs are classified into three main groups based on their structural properties and named after Mycobacterium sp. genes glbN, glbO, and glbP: TrHb1s (N), TrHb2s (O) and TrHb3s (P). This group includes a Mycobacterium tuberculosis TrHb2, Mt-trHbO, encoded by the Mycobacterium tuberculosis glbO gene, which is expressed throughout the Mycobacterium growth phase. It also includes a TrHb2 from the thermophilic Thermobifida fusca ( Tf-trHb) which has a high thermostability and at the optimal growth temperature for Thermobifida fusca (between 55 and 60 degrees C ), it is capable of efficient O2 binding and release. Tf-trHb shares a relatively slow rate of oxygen binding with Mt-trHbO.	1.30223e-64
NZ_CP046172.1\|WP_167473162.1\|2583314_2584076_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	0.00061839

>NZ_CP046172.1|WP_167473157.1|2575239_2576508_+|triacylglycerol-lipase
MSARRLSMLAGLGVCVLTAVSTAVAVAQPPIPLPSERQIYPAVVPLTPPESDPWYADPPNLDSLNNGDIVRTRDVQSYVLGIPIPVSTRQILYRSTDAHGTPLVTATTVLTPGIPWIGSPRPLVSYQEAIDSTANICNPSYTLRAGLFKEIALTQYFLEQGMAVVISDFNGKRNTALSPSEGRMVLDGIRAAKRDPALGLADSAVGLYGYSGGGNASASAAELHASYAPELPILGSAQGGVPGDKNALLDEVLGPVNLGNFFAQWAVWVFVNGVAREYPDVLKPEDLLTPDGVAHFDDMGNRCLWTEIAAGMLSPPMSTYLKDPNVLRRPEIQQVLHDISFGVDPAHRPDMPLFMWQSTTDQLIPPQVIHPTIEAYCRANVDLRYLEVPISEHISADVIGWPAATAWLSWVLRGGNPGPKTC
>NZ_CP046172.1|WP_167473156.1|2574571_2575036_+|DUF5130-domain-containing-protein
MASSKWPAVVEADLPHGYAITSSGRVSGVHEAGAVFKEAPFSDPERLAMDNVLTEATRATKVRFNIYIGHLGEDPAAGADAIFPKTPEAARSVLIAVSPNDKAIEVRSGREVADRANDRVCQLGVTAALSSFRQGQLIDGLVSAVRVMAAAIGR
>NZ_CP046172.1|WP_167473155.1|2574306_2574585_+|hypothetical-protein
MSILETVLIFVGIPLVIYGVIAGLSFLGKPLAGEKPTHFDLGQEWTAEPVLWSATDEVTGSGHHDSGSSHGSHAAIESAAAELIGGRASGKF
>NZ_CP046172.1|WP_167479120.1|2572650_2574237_+|glycoside-hydrolase-family-13-protein
MPAPVDRQAQSWWRSAVFYQVYPRSFADSNGDGIGDLGGVRDKLGYLELLGVDALWICPVMRSPMADGGYDVADPRDIDPMFGGLTALDELIAEAHDRGIKVTMDLVPNHTSSEHPWFIEALAAPPGSPQRSRYIFRDGRGPDGALPPNNWPSIFGGPAWTRVTEADGRPGQWYLHIFAPEQPDVNWDNPEVWQDFEKTLRYWLDRGVDGFRLDVAHGMAKPDGLPDMVDVPAGQLTHIDDDDPRFNNPAVHQIHRRIRKVLDEYPDAVSIGEVWVDDNHRFGEYLRPDELHLAFNFRLAETPFDADSVRGAIDNSLAAVATVDANPTWTLSNHDVDREVSRYGGGVAGLARARAMALVEFALPGAVFIYNGAELGLPNVDDLPEAVLQDPTWERSGHTVRGRDGCRVPIPWEGGEPPFGFTTGQPWLPLPPSWAELTVERQLEQLGSTLSLYRAAIELRGVRPEFAGPGLDWYGSPPGCLAFRRPGGLICVLNASPAPVALPPGTVILASAPLDGGLLPPDTAAWLV
>NZ_CP046172.1|WP_167473154.1|2571992_2572397_+|globin
MTSGEQTATSFYDAVGGADTFRRLVAAFYREVKADELLRPLYPEEDLGPAERRLRMFLEQYWGGPRTYSDERGHPRLRMRHMPFKIGPLERDAWLRCMRIAVAEIEPDVLDDQHRRALLDYLEMAANSLVNSPF
>NZ_CP046172.1|WP_167479119.1|2570908_2571421_-|HNH-endonuclease
MKRRVLLLNATYEPLTALSARRAVVLLICDKADAVHHDPEGSVVHSAGSTVAIPSVIRLRTYVRVPYRARVPMTRAALMHRDRYRCGYCGGKAETIDHVIPRSRGGEHSWENCVASCAPCNHRKADKLLSELGWTLHSPLVSPKGPHWRLLSTTSELDPVWLQYLGEGAA
>NZ_CP046172.1|WP_167473153.1|2570555_2570867_-|hypothetical-protein
MRWYVKLGLVGAALFVVGVAVFGYFGSSLWSSQHCDPDGETSHVVCYHGSWMAPHLRDIERRNDWARLKLSAAGAGIGAALIPISVFEWRRAKRKERRRSIAT
>NZ_CP046172.1|WP_167473152.1|2569934_2570552_+|helix-turn-helix-transcriptional-regulator
MGDDEWVPTDRYAPVVRFEPDAAQQSPQAIIATSLRRERVRAGISLTELANRAGIAKSTLSQLESGTGNPSIETLWALCVALDIPFSRLLDPPRPTIQVIRAGEGRVVAAEQADYQAALLAAGMSNSRRDIFRITAEPGHVRRSQPHMPGVLEHVILAAGRALVGLMDDPVELGPGDYILYPADVPHVFEALEPGTWAVLVNEYP
>NZ_CP046172.1|WP_167473151.1|2569150_2569855_-|branched-chain-amino-acid-ABC-transporter-permease
MRSIWRTLGRDAVTGIGGVLLAVGVMGISYGATVVASGLPVWLPIVLSYIVLAGGAEFLFTGIIASGGNPIAAMFAGLLVNARHLPYGLSVPDVVGTGWRRLIGIHVMNDEAVAVALAQPDPERKRAAYWLCGLGVGVVWPGGAAIGALIGALVPDTGALGLDAVFPAILLALVIPAFRDRITLRAALFGAVIAVAAAPFVPAGLPVLLALSGLLVAAWELTRPSRIAEKVAAQ
>NZ_CP046172.1|WP_167473150.1|2568842_2569154_-|AzlD-domain-containing-protein
MMLAIGMVALSLGTYAFRWAGPALRDRIRFPERAVRLLEIGAMVLLTALVAVTTIPTGTGKFGFALPAGVIVAGVLAVRKAPMLVVIVAAAATTAALRLCGVS
>NZ_CP046172.1|WP_167479121.1|2576679_2579250_-|aminopeptidase-N
MSAPNLTRDQAIERAATVRVENYRIDLDLTDGAGKPGEQTFFSRSTVTFTATPGASTFVDIVARGVRSAVLNGAPVEIGDYDEAKGIALTGLAERNELVVEADCEYSHTGEGLHRFVDPTDQAVYLYSQFETADAKRMFACFDQPDLKATFDITVTAPSDWQVISNSAATQPDPGKHVFATTPRMSTYLVALIAGPYARWTDEYTDEHGTIPLGIYCRASLSEYMDAERLFTETKQGFGFYHKSFGVPYAFGKYDQLFVPEFNAGAMENAGAVTFLEDYVFRSKVTRASYERRAETVLHEMAHMWFGDLVTMKWWDDLWLNESFATFASVLCQSEATEYTSAWTTFANAEKSWAYRQDQLPSTHPIAADIPDLAAVEVNFDGITYAKGASVLKQLVAYVGLEPFLTGLRQYFTEHAYANATFDDLLGALEKASGRDLSTWGAQWLKTTGLNILRPDFTVNEAGEFTSFAVVQEGAAPGAGERRVHRLAIGVYDDQDGKLVRTKRVELDLDAVERTEVPELVGVPRGKFVLVNDDDLTYCSVRLDPDSLNVLINRIGDIAEPLPRTLAWSAAWEMTRQAEMRARDFVALVQRGIGAETEVGVVQRLLMQANTALAAYADPEWLAASGWTGYADRLLELSRAAAPGSDHQLAFVNGLLATKLSGQHIEVLRKLLDADPAEVGLAGLAVDTDLRWRIVTALAAAGEIDADGVDHPFIDAELAKDPTAAGKRQAATAGASRPIAAVKEQAWQTAMFDDAVPNITIRAIVAGFSPVGQGELLAPFVERYFAEIPGVWERRSSEVAQTVVVGLYPSWAISEEAVAVADKFLADNHPPALLRLVSEGKAGIERSLRARAFDKE
>NZ_CP046172.1|WP_167473158.1|2579493_2580345_+|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MWRSALKHVHAGKVRDLYEDGDSLLLVASDRVSVYDVTLPTPIPEKGALLTQLSNWWFDFFTDVPNHVLSATDVPAEFAGRAIRCKPLKMVQVECIARGYLVGLGLKEYQRTGAVSGVQLPPGLVEGDKLPEPIFTPTTKASEGHDEFITFDDVVAQEGREVAELLRERTLDIYSRGAAHAAQRGVIIADTKLEFGWDGDVLTLGDEVLTSDSSRFWPADEWQPGRTQRSFDKQFVRDWATSTGWNQEPPGPEIPADIVEATRKRYVQAYELITGRAWTGVPA
>NZ_CP046172.1|WP_167473159.1|2580466_2580973_-|NUDIX-domain-containing-protein
MVAKFSAGILLFRMTDTTEVLLGHMGGPFWAKKDSGAWSLPKGEYDPATEEPRAAAAREFTEELGLPVPDGEWVALGDVTYGSGKSRKQLSAWAIEGDLDAGAIVPGTFEMEWPPKSGKLAEFPEIDRAGWFDLATAADKLGAGQRPLLDRLAELIANRRTAGTVMGD
>NZ_CP046172.1|WP_167479122.1|2581051_2581675_+|hypothetical-protein
MGFDDSVNELLRRLPDIPILRNRCRAMAILDAVLSPEWEYRYYSFDSRWGDGAEMASMRNGSGDNWFIVFSGAGVYGRGFDHEAPNAPQVLDAVPPVFGPYVTEPAFAAHDGSPLATVCFWREPRDTAWGVSAADRGGRGLFELLVEGTPEAYRDWAENYYETEVSLSAVQHVYALQPLTPTVLAELDPDIEFADLEQDIIQIDYPH
>NZ_CP046172.1|WP_167473160.1|2581992_2582517_-|hypothetical-protein
MIVAGVLAGAVSFGAPGWVAPAAAKPDTVVMTCDETGNVTWLGAGITDTKAKVDWENTKHYDNCKLPDGSTPQVYPERSVAMGTELASCDAVESHEGRGEMSWSDGSTTTFKQKASKQSKFKGNGTGEFTLIIEDGNDFTGDTAIDKDTLTKKESKSCPGLTSATTKGTLTIYK
>NZ_CP046172.1|WP_167473161.1|2582855_2583173_+|hypothetical-protein
MEPQARVRYEVVRCSVYGHAPYGLLIESEDGERGFVDSSYITDNPGEPWPAVGQQLRCVVLCYTGDGRLCAAAIPLYVEMVAAADDPAAAADQWGSLTGRGRQHD
>NZ_CP046172.1|WP_167473162.1|2583314_2584076_+|GNAT-family-N-acetyltransferase
MIEPERDIETIFDSRGTALAHYEPGRRGDRQWAEDLRWADPGDQSAVTPILRALPGWGATTDADLGAALLNAGAHRVRLFHTYTRDLTGMAPIEPELPSGLRPVPASEVAPAALQDAFSAAYPSAHPDHDVDGLQTLAALYDGSLMGPLLPCSTVAWDGRRAVAAVLVQDTGGEPPLEGAWISDVFRRPGPDHAGLGALLLRVVLARAASSGIAALGLSVTDGNPARIVYERIGFHHTASWIDLIFPASQPTT
>NZ_CP046172.1|WP_167473163.1|2584261_2584504_-|hypothetical-protein
MKTAVEQLLAEEFQGGWDFNVEIKQRSESEVYVVIESLDTVIIGGNGSWTDVFDGLLRERVSAVAADAKTNTEWTWPDYP
>NZ_CP046172.1|WP_167479123.1|2584584_2585853_-|IS256-family-transposase
MTRKKKPVEASAEELAAQELVRMAKERGLSLTGPDGLLKQFTKTVLETALNEEMTDHLGYDKHEAPAERETSNVRNGTRPKTVLTESSGHVQIDVPRDREGSFEPQIVRKRQRRLTGVDEIVLSLYAKGLTTGEISAHFAEIYGASVSKETISRITDKVVAEMQEWSCRPLDEIYVAIFIDAIVVKVRDGQVANRPIYAAIGVTVSGEKDVLGLWAGTGGEGAKFWMGVLTDIRNRGVKDVFFVVCDGLKGLPEVVGNVWPLATVQTCVIHLIRNTFRLVSRQHWDALKRDVKPIYTAVNADAARAALDELTEQWGAKYGAVVRLWNNAWEQFIPFLDYDVEIRRVICSTNAIESLNARYRRAIKARGHFPTEQAALKCLYLVTRSLDPTGQGRARWTMRWKPAVNAFAITFADRWPDAQTY
>NZ_CP046172.1|WP_167473164.1|2586061_2586511_+|PPOX-class-F420-dependent-oxidoreductase
MSDALDDEIRDWLRRPWFWVMGTLNPDGGPQLTPMWAGLETIDGTEWIVVDTSRGRMKEQNLRRDPRLSLCSFSPDNPYDRVEIRGRAAGFVEGAPASRIMDRLAQKYLGTETFPWPIDGEVRVAVLIKPDYVHRTIGVEPFRPGVLPT

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Crispr_ID: NZ_CP046172_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046172_6

3289996-3290117

Orphan

Consensus_repeat	Method
CCCCAGCCGGAACACTGAGGTGCTCGCATCGTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046172_6

>merge|NZ_CP046172|6|3289996-3290117|CRISPRCasFinder
CCCCAGCCGGAACACTGAGGTGCTCGCATCGTGCGTTGCCGAGCTGTGCTGCCTCCCATTGGCCGCGATTGTGCTGGCGTGGGTGCTGCCCCAGCCGGAACGCTGAGGTGCTCGCATCGTGC

>NZ_CP046172|6|6|3289996-3290117|CRISPRCasFinder
CCCCAGCCGGAACACTGAGGTGCTCGCATCGTGC	GTTGCCGAGCTGTGCTGCCTCCCATTGGCCGCGATTGTGCTGGCGTGGGTGCTG
CCCCAGCCGGAACGCTGAGGTGCTCGCATCGTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046172.1\|WP_167479198.1\|3294590_3295478_-\|SURF1-family-protein	unknown	unknown	gnl\|CDD\|225883
NZ_CP046172.1\|WP_167473710.1\|3287880_3288765_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP046172.1\|WP_167473714.1\|3295480_3295990_-\|low-molecular-weight-phosphotyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|319971
NZ_CP046172.1\|WP_167479200.1\|3300227_3300965_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224495
NZ_CP046172.1\|WP_167473707.1\|3285490_3286006_-\|gamma-carbonic-anhydrase-family-protein	unknown	unknown	gnl\|CDD\|100051
NZ_CP046172.1\|WP_167473709.1\|3287065_3287827_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293841
NZ_CP046172.1\|WP_167473711.1\|3290356_3291472_+\|alanine-dehydrogenase	unknown	unknown	gnl\|CDD\|240630
NZ_CP046172.1\|WP_167479195.1\|3282799_3284422_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235906
NZ_CP046172.1\|WP_167473708.1\|3286015_3286993_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|181818
NZ_CP046172.1\|WP_167473715.1\|3296034_3297072_+\|threonine-phosphate-decarboxylase	unknown	unknown	gnl\|CDD\|236128
NZ_CP046172.1\|WP_167473706.1\|3285172_3285358_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167473713.1\|3293475_3294420_+\|cobalamin-biosynthesis-protein	unknown	unknown	gnl\|CDD\|234919
NZ_CP046172.1\|WP_167473703.1\|3280830_3281439_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP046172.1\|WP_167473712.1\|3291473_3292505_-\|RNA-polymerase-sigma-factor-SigJ	unknown	unknown	gnl\|CDD\|236600
NZ_CP046172.1\|WP_167473702.1\|3279892_3280843_+\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|272862
NZ_CP046172.1\|WP_167473716.1\|3297454_3298576_+\|Nif3-like-dinuclear-metal-center-hexameric-protein	unknown	unknown	gnl\|CDD\|376614
NZ_CP046172.1\|WP_167473704.1\|3281475_3281838_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167479199.1\|3299344_3299989_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167473705.1\|3284423_3285047_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP046172.1\|WP_167479197.1\|3292833_3293421_+\|MspA-family-porin	unknown	unknown	gnl\|CDD\|370360

Protein	Function_ID	Function_description	E-value
NZ_CP046172.1\|WP_167479198.1\|3294590_3295478_-\|SURF1-family-protein	gnl\|CDD\|225883	COG3346, COG3346, Uncharacterized conserved protein [Function unknown].	6.17503e-52
NZ_CP046172.1\|WP_167473710.1\|3287880_3288765_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.54361e-26
NZ_CP046172.1\|WP_167473714.1\|3295480_3295990_-\|low-molecular-weight-phosphotyrosine-protein-phosphatase	gnl\|CDD\|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	1.33154e-57
NZ_CP046172.1\|WP_167479200.1\|3300227_3300965_+\|hypothetical-protein	gnl\|CDD\|224495	COG1579, COG1579, Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only].	3.61668e-34
NZ_CP046172.1\|WP_167473707.1\|3285490_3286006_-\|gamma-carbonic-anhydrase-family-protein	gnl\|CDD\|100051	cd04645, LbH_gamma_CA_like, Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Gamma CAs are trimeric enzymes with left-handed parallel beta helix (LbH) structural domain.	8.20925e-81
NZ_CP046172.1\|WP_167473709.1\|3287065_3287827_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293841	cd16283, RomA-like_MBL-fold, Enterobacter cloacae RomA and related proteins; MBL-fold metallo hydrolase domain. Derepression of the romA-ramA locus results in a multidrug-resistance phenotype. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	9.79917e-26
NZ_CP046172.1\|WP_167473711.1\|3290356_3291472_+\|alanine-dehydrogenase	gnl\|CDD\|240630	cd05305, L-AlaDH, Alanine dehydrogenase NAD-binding and catalytic domains. Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.	0
NZ_CP046172.1\|WP_167479195.1\|3282799_3284422_+\|hypothetical-protein	gnl\|CDD\|235906	PRK07003, PRK07003, DNA polymerase III subunit gamma/tau.	5.22447e-07
NZ_CP046172.1\|WP_167473708.1\|3286015_3286993_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|181818	PRK09393, ftrA, transcriptional activator FtrA; Provisional.	2.0177e-99
NZ_CP046172.1\|WP_167473715.1\|3296034_3297072_+\|threonine-phosphate-decarboxylase	gnl\|CDD\|236128	PRK07908, PRK07908, threonine-phosphate decarboxylase.	4.4109e-166
NZ_CP046172.1\|WP_167473703.1\|3280830_3281439_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.59631e-13
NZ_CP046172.1\|WP_167473712.1\|3291473_3292505_-\|RNA-polymerase-sigma-factor-SigJ	gnl\|CDD\|236600	PRK09636, PRK09636, RNA polymerase sigma factor SigJ; Provisional.	1.99818e-110
NZ_CP046172.1\|WP_167473702.1\|3279892_3280843_+\|SAM-dependent-methyltransferase	gnl\|CDD\|272862	TIGR00027, Hypothetical_protein_Rv0893c/MT0917/Mb0917c., methyltransferase, TIGR00027 family. This model represents a set of probable methyltransferases, about 300 amino acids long, with essentially full length homology. Members share an N-terminal region described by Pfam model pfam02409. Included are a paralogous family of 12 proteins in Mycobacterium tuberculosis, plus close homologs in related species, a family of 8 in the archaeon Methanosarcina acetivorans, and small numbers of members in other species, including plants. [Unknown function, Enzymes of unknown specificity].	1.47987e-45
NZ_CP046172.1\|WP_167473716.1\|3297454_3298576_+\|Nif3-like-dinuclear-metal-center-hexameric-protein	gnl\|CDD\|376614	pfam01784, NIF3, NIF3 (NGG1p interacting factor 3). This family contains several NIF3 (NGG1p interacting factor 3) protein homologs. NIF3 interacts with the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of this interaction is unknown.	1.15551e-43
NZ_CP046172.1\|WP_167473713.1\|3293475_3294420_+\|cobalamin-biosynthesis-protein	gnl\|CDD\|234919	PRK01209, cobD, cobalamin biosynthesis protein.	4.87756e-118
NZ_CP046172.1\|WP_167473705.1\|3284423_3285047_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	8.90351e-12
NZ_CP046172.1\|WP_167479197.1\|3292833_3293421_+\|MspA-family-porin	gnl\|CDD\|370360	pfam09203, MspA, MspA. MspA is a membrane porin produced by Mycobacteria, allowing hydrophilic nutrients to enter the bacterium. The protein forms a tightly interconnected octamer with eightfold rotation symmetry that resembles a goblet and contains a central channel. Each subunit fold contains a beta-sandwich of Ig-like topology and a beta-ribbon arm that forms an oligomeric transmembrane barrel.	2.60434e-47

>NZ_CP046172.1|WP_167473710.1|3287880_3288765_-|AraC-family-transcriptional-regulator
MSIIGHEPVLNSELPAATRTRTVQAGDRIERHRHPEHQLVYLSSGVAEIRTAGGSWLAPTDRAIWIPGGYWHEHHFYGPTRFHTVAFPLDQSLGGTTPSVLAVHPLLRELIIACSMPGPLPDEELRRMRQVLLDQLRRSTEQPLRLPVATDERLRRACELIEDDLTVGWSLAELGHRVGAAERTLSRLFRTEFGMTYPQWRTQLRLHRAVQLLADAVPVTVVAHRCGWATPSAFIDVYRRTLGHTPGSYRSARESDSPSTYALPRLTREPGAQPPRGRTIAPEPDTPTAHRSPK
>NZ_CP046172.1|WP_167473709.1|3287065_3287827_+|MBL-fold-metallo-hydrolase
MSTNNVQLTALHIGGPTLRFEYGGLTWLTDPTFDEPRDYQGGVTLHKLTGPAVPVDEIGPVDVVLLSHDEHADNLDESGREFLGTVETVLSTPEAAGRMNGVRGLANWESVKIGDVTVTWVPALHGPEGCEPLTGTVTGFVLQADGQPTVYFSGDNASVDLVRQIAERFERIDVAILNIGAANVGRFGDIDLTLNGRTAVEAAELLGDAAIIAIHAEGWAHFSESLDYLERNFGYAGRATQLHVPPLGKVFAV
>NZ_CP046172.1|WP_167473708.1|3286015_3286993_-|helix-turn-helix-domain-containing-protein
MRTVAVLAFDGNSPFHLSVPALVFGRIGVEGKAPYRIEICAERPGSLSTPAGFEIVVHHGLESFATADLVVIPSWPRGQDISDELRAALHGAHARGARIVGLCLGAWVIAASGLADGREITTHWASATELARAYPAVRVRADTLWTDLGDVVTSAGVAAALDCCLHLVRADLGSRAATELARSLVTAPHRSGSQAQYIPVAVPDAADDDPIERAMVWARTHLGDPIDLDGWAAVALMSRRTFTRRFRERTGDSPQQWLLHQRADRARLLLESTDDTVDRIAAETGFGTAVSLRHHFHRILGTSPAAHRALFHLAEPNDRGTRPYR
>NZ_CP046172.1|WP_167473707.1|3285490_3286006_-|gamma-carbonic-anhydrase-family-protein
MQLEVGGFTPEIDEGAWLAPNATVIGRVTLAAEVSVWYSAVIRGDMEAIAIGERTNIQDGCVLHADPGFPLTVGSGVSVGHNAILHGCTVGDDVLVGMGATVLNGAVIGAGSLIAANALIPEGAQIPPGSLVAGVPGKVRRELSEAEQDGIRLNGAVYVHNMANHRAARTV
>NZ_CP046172.1|WP_167473706.1|3285172_3285358_-|hypothetical-protein
MAYGQDSMHRPVGRISVADIAAQPGGIEALQRRVHELRSRGVDFAANAIEQEMVALDLPRP
>NZ_CP046172.1|WP_167473705.1|3284423_3285047_-|TetR/AcrR-family-transcriptional-regulator
MPTVPSMLQRILDKPVADGEKLLESALSAFLDFGIKRTSMGEIARRAGISPATLYRRFESKNELVEAVSVREAQRFVAEIDKRVQGVQGSDEQLVEIFVAFITAIAGNELLRRLLRTEPELILPRLTTDAGPVLAVGRGYLAEKLRELRDAGGVDDFDAELVAEIMARLALSLALTPDGLIPIEDAEAGRNFARRTLLPMVGVRAPA
>NZ_CP046172.1|WP_167479195.1|3282799_3284422_+|hypothetical-protein
MNAAATTDLTSAQSCSQGGDGNLPATTDSSESHDNAAATGASAGFTVPGSAAAEPTGGADALDSADPRDEAAGTAFSAIGARAVPGCAAASAGRADAAVSAESGGTATTGGAAPGSMAGPGSMAGPGAMAGLGSVTPSAGRMDTLGAARPTDTAAAAGASAGLAVPGSAAEPIGGADALGAADPGDEATAAAFSATEYRAVPGCVAASAGRADAAVSVESGGVATTGAADALDSADPSDEVSAAVVSGRGLVRPVDALLPAVMRAGGEGAWRMSRPEVDAWLGRIGARTWRTFGEVGRIRVGIKTTADRVFISDRWGERVPRPEAALLLALITHDDVAAWRVRRAGDTRVLYPYDTARPVRTPIDLAEFPCAAEYLRTHKDTLAARGYVIAGGREWFEIWVPQRPHLWRAPKVVFPDISDRPRFALDRSGAVVNGDCYWISLTDLAQAGDAERLAYLLMGVANSALGLRFYDAVCGNRLYSGRRRWITQYVSRLPLPDPAASAAAEIIALARDLADGSAAPDADALGELDERVSAAFGLR
>NZ_CP046172.1|WP_167473704.1|3281475_3281838_-|hypothetical-protein
MSATDPVFSHAHILFTAVVTAAITAPFAVWRLGRAEWIDTVGVTIVTGAATWLWRTSANLPQLNTDGLPGFSANDWLAPVLTYVLLSLYAALRPPRDLHRYNQTRAIAVLVSLAVNVITI
>NZ_CP046172.1|WP_167473703.1|3280830_3281439_+|TetR/AcrR-family-transcriptional-regulator
MPRLTPATERERRRRIIDAALDCFAERGLHATTMQDICRRSGLSPGAVYCWYPSKEAIIDAVADERHRHERELLETALRAADPRTALRTFLDAYFDWLADPAEQRRRRVSVLVWAESLVNERMRPGVDEGIAQRTMALDAIRSGQAAGVITGRADADAITRIALALIQGFILQQAWEPDIDIAGYRRALDLVVEAVAPAAGQ
>NZ_CP046172.1|WP_167473702.1|3279892_3280843_+|SAM-dependent-methyltransferase
MRSRNPIRRVCQLSLDGDTNRIYILFVVSFTAQTMAFQRALESARPTESRLFTDPLATRFLSPPLRALAGMARIPVAGSLVARLYDLAFPGPRPSAVARTRLIDDTIVELVAGGVRDIVVLGAGFDSRPWRLPELRGARIVEVDRAGTQAVKAAAVRAAGVDTGRVGFLPVDFETDDLATALRAGGVGERRTLFVWEGVTNYLTAAAVDRTLAVLRRVGGPDGMLVFTYVHAGVIDGTATFPEAERWLRGVARVGEPWTFGLDPDRLGAFLAARGYELIWEQSTAAAGDRYFRPRGRADRASELYRVALARIACPA
>NZ_CP046172.1|WP_167473711.1|3290356_3291472_+|alanine-dehydrogenase
MKIGVPREVKEQEFRVALTPAGAGELVALGHEVLVETGAGVGSGFADSDYTAKGAALAADADRVWWAADLVLKVKEPIPVEYSRMRSEQVLFTYLHLAASRECTDAILRSGITAIAYETVRAADGSLPLLAPMSEVAGKLGAQVGAYHLMAPLGGSGVLLGGVPGVRSADVVVIGGGVAGANAAAVAAGMGARVTVLDTNLARLRELDVRFRGRVSTLASNAAELEKAVLAADLVIGSVLVPGARAPKLVSNELVAAMRPGSVLVDIAIDQGGCFAGSHPTTHANPTFRVADSLFYCVANMPGAVPHSSTVALTNATLPYVKAIATQGWKVACSANPELAHGLTADAGVLRSVEVAAAHGYSAPRPVGLVG
>NZ_CP046172.1|WP_167473712.1|3291473_3292505_-|RNA-polymerase-sigma-factor-SigJ
MSHWTVPRRHPDDPLLNSASTGQARRTATAVNSEQRPHSTDRAELARQFEEHRPYLRRLAYSTLGSLADADDVVQEAWLRLQRQQDAGKAGEIDNLRAWLTTVTGRLALDYLGSARARREQYVGEWLPEPEVTTIDDPADRVTQDERVTTALLVVLESLSPAERTAFVLQDVFGMSGPEVAKVVGRTPAAVRQLASRARKRVEEGTPRFPASADEQQKVVSAFAVAWRSGDLSALLGVLDSNVSLAADGGGKVPAIRQPVRGAELVAKMLLGWYHAPSAQGAWGRAVLVNGEPGLVVFDGTHTGVFSFTVDGGRIVAINVIRNPEKLRDLPTDGDPDWYLNAR
>NZ_CP046172.1|WP_167479197.1|3292833_3293421_+|MspA-family-porin
MLMGSGSAAAEVAADKSRTTQTDDGWDLTVTKTAETLDRYPNLASTPTTREGFVSLKGIAEYHGAGKHKVDAGDIAFGYQLGCQVDVSSGLQLGLGFSFGPNVGVTVGGTPGVTVGGSAAVIPTMQTTLKPGTITTIVFGTKPLAGQRASIAAEQVEIKVDACAGPVTLRSFATATIKTSAADHAVTVYGDPMTL
>NZ_CP046172.1|WP_167473713.1|3293475_3294420_+|cobalamin-biosynthesis-protein
MSTGTSTAAGLLLGFALDRAFGDPRRRHPVAGFGTAASKLEAITYADRRSAGVLHEAIAVGAVAGLGVLLRRGGIAATALATWTVLGGHTLARTGRAMADRLEAGDLAGARALLPSLCGRDPDVLDADGLARAALESVAENTSDAAVAPLWWGSVAGVPGLLAYRAINTLDAMIGYRNERYLRFGWAAARVDDLANLIPARITGLLTAALAPLIGGRPADALRAWRRDAVKHPSPNAGVAEAAMAGALGVRLGGRTQYRYGTELRPTLGDGPAPGISDLRRAVLISEGVQVAAVLGAALWAAVGLCPLGARINR
>NZ_CP046172.1|WP_167479198.1|3294590_3295478_-|SURF1-family-protein
MRRLSFLLRPSWVILAIIVIAFAYLCFTVLAPWQLGKNTTTSHRNQLIADSVHADPVDVLAAADGRVQVHEWQRVTANGAYLPDSTVLVRLRHLDDKPAYSVLGAFKLDDGRIVLVDRGLVAAVNGTRPPEIAAPPSGPQRIEGRIRVAEGVIPGKDPSVQDGYRQVYSIDVTQEMTTLQLPLTALPGGDRGGYLQLESGQPGAFTPDPLPQLDSGPYLSYGLQWLAFGIMAPLGLGYFVYAEIRERRKEKGSAKGESGSASTEPVNPKPEPQAPEPKPAPTATETRLADRYGRK
>NZ_CP046172.1|WP_167473714.1|3295480_3295990_-|low-molecular-weight-phosphotyrosine-protein-phosphatase
MSVVGELHVSFVCTGNICRSPMAEKIFAAQLHRAGLADRVRVSSAGTTAWHAGEEADPRTNSTLREHGYPTGHSAAKLDVDHLSADLLVALDRGHDRDLARLGVPPDRHRLLRSFDPSADGPDVPDPYYGDLSDFELVREQIEAAVPGLLAWVRAALGDTPETTKGGHR
>NZ_CP046172.1|WP_167473715.1|3296034_3297072_+|threonine-phosphate-decarboxylase
MAGNSADHAKLRYHGDVAARPGLLDFAVNVRAAAPPDWLRARLAARLGELGRYPDAAEELAARTAVAARHGRTPEQVLLLAGAAEGFAMLPRLAPRLAAVIHPSFTEPELALREAGIAVTRVLLDAPYLLDPALVPADADLVVLGNPTNPTSVQHCAATILALRRPGRVLVVDEAFADAVAGEPESLARRSFPDVLVLRSLTKTWALAGLRCGYWLGAPELLARLAHGRAHWPLGTLQLEAIAATATPSAVAETERSAKVIAAERASMIERLRELGVAVHTPAEGPFLLLRVPDGELLRKRLIDLGIAVRRADTFPGLDQNHLRVAVRDAQAVDRLIAAIAAVGL
>NZ_CP046172.1|WP_167473716.1|3297454_3298576_+|Nif3-like-dinuclear-metal-center-hexameric-protein
MTTLGELIGVLDAAYPPRLAESWDSVGLVCGDPAEEVTRVLFAVDATAGVVDEAVTWGAQALVVHHPLLLRGVDTVAADTPKGALLHRLIRAGCALFTAHTNADSADPGVSDALAGALGLTVTGPLDAKPEAPVDNWVVQVPSSHSDAVLAAMFAAGAGGSGDYRDCALRVPAVGQFRPMAEANPAIGSHGELQRVDEERLEVIAPPSVRAAVLGALRAAHPYESPAYHISERALLPAPVGIGRVGNLPEPESLRTFTERVAAALPPTVWGVRAAGDPDRAVYTVAVCGGAGDSYLDTVARLGVDAYVTADLRHHPVDERLRRGGPALVDAAHWATEFPWCAQAQSVVGNAMPELETRVSNVRTDPWTVGAKS
>NZ_CP046172.1|WP_167479199.1|3299344_3299989_+|hypothetical-protein
MNFPVEFGFVQVGLILIIVVGLALLVTAILRVRKVGLRVLIGRGASGLVLLLTAVVLLWVATLMQTYLGLTGEIKAAHVVASAVPGQDHQLKIDLTLYGDDEHPEQRKTYQVEGDLWVLQANIVELEPWVNALGFHSGYKVSRLYGQRLDGVATSQHQIFLNGDDQDFFSDMRSGKWWTDPFVRSAYGNAVISMPGDYDVYISRDAIKTRGAGH
>NZ_CP046172.1|WP_167479200.1|3300227_3300965_+|hypothetical-protein
MNVEPSVQAKLLQLAAVDAELTRIAHRRAVLPEQQEVARLEAERNAQKDAAVAVEIVLDDLDRDIRKLEGEVDAVRKREQRDRGLLDAGSVGAKQYSDIQHELGSLERRRSVLEDELLEVMERREASAADHEHAGARLSKAEADLADAERQRDEALADLEVAQGRCDGERAGLIGLFPAELLAIYDKQRAQHGVGAALLQARKCGACRIELDRGELARIAKTAPEVIVRCPECGAIMVRTRESGL

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Crispr_ID: NZ_CP046172_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046172_7

3312395-3312487

Orphan

Consensus_repeat	Method
TCGGGTGACATGCGCGGTGCGAAATGAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046172_7

>merge|NZ_CP046172|7|3312395-3312487|CRISPRCasFinder
TCGGGTGACATGCGCGGTGCGAAATGAGCGGGTGAGATGTCGACTACCGAGCGGCAACGGGTCCTCGGGTGACATGTGCGGTGCGAAATGAGC

>NZ_CP046172|7|7|3312395-3312487|CRISPRCasFinder
TCGGGTGACATGCGCGGTGCGAAATGAGC	GGGTGAGATGTCGACTACCGAGCGGCAACGGGTCC
TCGGGTGACATGTGCGGTGCGAAATGAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046172.1\|WP_167473733.1\|3322950_3323337_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167473726.1\|3316443_3317040_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376577
NZ_CP046172.1\|WP_167473725.1\|3312506_3313271_+\|DUF4111-domain-containing-protein	unknown	unknown	gnl\|CDD\|379178
NZ_CP046172.1\|WP_167473731.1\|3319467_3320355_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|225989
NZ_CP046172.1\|WP_167473729.1\|3318147_3318768_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP046172.1\|WP_167479203.1\|3304650_3305079_+\|SgcJ/EcaC-family-oxidoreductase	unknown	unknown	gnl\|CDD\|274053
NZ_CP046172.1\|WP_167473724.1\|3311847_3312225_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167473728.1\|3317405_3318110_-\|DUF4386-family-protein	unknown	unknown	gnl\|CDD\|379558
NZ_CP046172.1\|WP_167473727.1\|3317080_3317365_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167479205.1\|3306304_3306562_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274680
NZ_CP046172.1\|WP_167473723.1\|3309844_3311047_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|169028
NZ_CP046172.1\|WP_167479204.1\|3305166_3305643_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP046172.1\|WP_167479207.1\|3321910_3322759_+\|slipin-family-protein	unknown	unknown	gnl\|CDD\|259808
NZ_CP046172.1\|WP_167473722.1\|3308139_3309381_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP046172.1\|WP_167473730.1\|3318798_3319317_-\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|349964
NZ_CP046172.1\|WP_167473721.1\|3306796_3307360_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|239646
NZ_CP046172.1\|WP_167473720.1\|3306567_3306747_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167473719.1\|3305712_3306240_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239516
NZ_CP046172.1\|WP_167479206.1\|3307400_3307970_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP046172.1\|WP_167473732.1\|3320892_3321366_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181

Protein	Function_ID	Function_description	E-value
NZ_CP046172.1\|WP_167473726.1\|3316443_3317040_-\|hypothetical-protein	gnl\|CDD\|376577	pfam01619, Pro_dh, Proline dehydrogenase.	0.00415965
NZ_CP046172.1\|WP_167473725.1\|3312506_3313271_+\|DUF4111-domain-containing-protein	gnl\|CDD\|379178	pfam13427, DUF4111, Domain of unknown function (DUF4111). Although the exact function of this domain is not known it frequently appears downstream of the family Nucleotidyltransferase, pfam01909. It is also found in species associated with methicillin-resistant bacteria.	4.44275e-07
NZ_CP046172.1\|WP_167473731.1\|3319467_3320355_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|225989	COG3458, COG3458, Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism].	2.50815e-11
NZ_CP046172.1\|WP_167473729.1\|3318147_3318768_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.69462e-10
NZ_CP046172.1\|WP_167479203.1\|3304650_3305079_+\|SgcJ/EcaC-family-oxidoreductase	gnl\|CDD\|274053	TIGR02246, hypothetical_protein, conserved hypothetical protein. This family consists of uncharacterized proteins found in a number of genera and species, including Streptomyces, Xanthomonas, Oceanobacillus iheyensis, Caulobacter crescentus CB15, and Xylella fastidiosa. The function is unknown.	1.53528e-18
NZ_CP046172.1\|WP_167473728.1\|3317405_3318110_-\|DUF4386-family-protein	gnl\|CDD\|379558	pfam14329, DUF4386, Domain of unknown function (DUF4386). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 214 and 245 amino acids in length.	0.000297249
NZ_CP046172.1\|WP_167479205.1\|3306304_3306562_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274680	TIGR03619, F420_Rv2161c, probable F420-dependent oxidoreductase, Rv2161c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity].	1.72271e-10
NZ_CP046172.1\|WP_167473723.1\|3309844_3311047_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|169028	PRK07588, PRK07588, FAD-binding domain.	3.07704e-90
NZ_CP046172.1\|WP_167479204.1\|3305166_3305643_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	5.64306e-16
NZ_CP046172.1\|WP_167473722.1\|3308139_3309381_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	2.27654e-97
NZ_CP046172.1\|WP_167473730.1\|3318798_3319317_-\|RNA-methyltransferase	gnl\|CDD\|349964	cd18091, SpoU-like_TRM3-like, SAM-dependent tRNA methylase related to TRM3. Yeast tRNA (guanosine(18)-2'-O)-methyltransferase TRM3 catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs. TRM3 is similar to C-terminal domain of TAR (HIV-1) RNA binding protein 1 (TARBP1), a protein binding to TAR, which functions as a RNA regulatory signal by forming a stable stem-loop structure to which transactivator protein Tat binds. The role of TARBP1 is believed to be to disengage RNA polymerase II from TAR during transcriptional elongation. TRM3 and the C-terminal methyltransferase domain of TARBP1 are members of the SPOUT methyltransferase superfamily.	3.86354e-41
NZ_CP046172.1\|WP_167473721.1\|3306796_3307360_-\|NUDIX-domain-containing-protein	gnl\|CDD\|239646	cd03674, Nudix_Hydrolase_1, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, U=I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.60822e-19
NZ_CP046172.1\|WP_167479206.1\|3307400_3307970_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	4.89474e-10
NZ_CP046172.1\|WP_167473719.1\|3305712_3306240_-\|NUDIX-hydrolase	gnl\|CDD\|239516	cd03424, ADPRase_NUDT5, ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, for its activity. It also contains a highly conserved 23-residue Nudix motif (GX5EX7REUXEEXGU, where U = I, L or V) which functions as a metal binding site/catalytic site. In addition to the Nudix motif, there are additional conserved amino acid residues, distal from the signature sequence, that correlate with substrate specificity. In humans, there are four distinct ADPRase activities, three putative cytosolic enzymes (ADPRase-I, -II, and -Mn) and a single mitochondrial enzyme (ADPRase-m). Human ADPRase-II is also referred to as NUDT5. It lacks the N-terminal target sequence unique to mitochondrial ADPRase. The different cytosolic types are distinguished by their specificities for substrate and specific requirement for metal ions. NUDT5 forms a homodimer.	2.66666e-36
NZ_CP046172.1\|WP_167479207.1\|3321910_3322759_+\|slipin-family-protein	gnl\|CDD\|259808	cd08826, SPFH_eoslipins_u1, Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model summarizes a subgroup of the stomatin-like protein family (SLPs or slipins) that is found in bacteria and archaebacteria. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Bacterial and archaebacterial SLPs remain uncharacterized. This subgroup contains PH1511 from the hyperthermophilic archaeon Pyrococcus horikoshi.	6.76651e-97
NZ_CP046172.1\|WP_167473732.1\|3320892_3321366_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.68607e-13

>NZ_CP046172.1|WP_167473724.1|3311847_3312225_-|hypothetical-protein
MWRTILAVVTLAAVTVVGIGASGQAGAVSDKVTCGAVAQAATDMAAALGDGDVGIADVKKALHDVATKLADAAVAADEGPLKSALNADVAQLNRAATAPDDQVMNILHEQESKDARDAVNSRCGF
>NZ_CP046172.1|WP_167473723.1|3309844_3311047_+|FAD-dependent-oxidoreductase
MRILVSGASIAGPVLSYWLTRYGFTVTVVEKAPTLRKTGGHAVDLFRPSVEISEQMGVLPRIMEHATGTDYLTVHTGSRRVRLDQAKLARAASDRHVEIMRDDLSEIYYDATRNDVEYRFGDSITAITADGRVSFEHSEPREFDLVVGADGLRSNVRRLVFGQVPERFLGGYLAVASAPRELAVPGEFNARLAVGRVAGIYTAQCLTDSRILFLFRPEQELDYDHRDIDQQKRLVRKAFAGSAPEVDRWLAVLDDTPAFYFDSITQLRLDRWSRDRVTLVGDAAYCPGPAVGGSTSLAIVGAYTLAGELAAAGGDHTVALPAYEAVMAESVRRSRIFAARAAATIVPTSRLGMWALIQAGRLGTALPTGLARAATKLGARGLRFYDSMPVKDYDTPLASV
>NZ_CP046172.1|WP_167473722.1|3308139_3309381_+|cytochrome-P450
MTTTDEPIGIADYLSLIDPANRPDPYPLLARMRAAGPFRLGSAPVVVFPGYADCATVLRHPDARVDRRLSAFELSQFPDPRTGDDERGPAFLFRDPPDHTRLRRLVAKAFTPRVVQTMEPRITALVDGILDRVSGTEFDVVAELAYPLPVTVICELLGVPLEGEARLGRWSALMSRKLDPTSRSTAEFAADPAAVDQASDELYEYFEELTVRRRADPGPDLLSELIAAEEAGDKLSHDELISTCGLLLIAGHETTVNLIGNAVLALLRNPEQLAALRADPALAAAVVEETLRYDPPVQLAPRIAAADLRIGDFPVRRGEVMIMLLAAAQRDPRLNPDPDRFDPRRDIRHLAFGAGAHFCLGAPLARLEARVALTRFALRVREPRLLLDPPPYRDHVTLRGPAALPVGFTEIAP
>NZ_CP046172.1|WP_167479206.1|3307400_3307970_-|TetR/AcrR-family-transcriptional-regulator
MAPEQRRAQLLDAALRIIVEQGIHKVSMDAVARSAGVTRPVVYSQFTDTDDLLRSSLEREEQLARQQLSDIVPLRPTGDPAADVLRYLAGFLRAVTEAPDRWRAAFVLVDSATPYFRRRMEHWRRELVTALEDFVRAATTDLDVAMTARAIDALVWNAGRLTLAEPGEFPPARVIAYYTDLVRTHFDRR
>NZ_CP046172.1|WP_167473721.1|3306796_3307360_-|NUDIX-domain-containing-protein
MHPATAVIAEIVRGIEPFDALECEHIAQTLRWLDATDDVFRRAKPATPPRHLVTYAVLVDPDGRAVLLGLHRLAGLWLPTGGHVEPGEHPLAAARRETLEELGIEPDFGVVGTAPLFLTITTTIGIDAGHEDVSLWYVVRGDRTREYRLDPREFGDGRWWDIDRFAVPESDPHFGRFLGKLEAAILP
>NZ_CP046172.1|WP_167473720.1|3306567_3306747_-|hypothetical-protein
MLIGELAERIGTRTCGITNSTAWCERAARQVDATMDQLAALREQLLARLRAAPPKCEFH
>NZ_CP046172.1|WP_167479205.1|3306304_3306562_-|LLM-class-flavin-dependent-oxidoreductase
MRFAISYSSPFHGVDPDRLIAVARHAERCGFEGLYLPDHLALYPGAMFGAVELPTQLPYLEPLDALSFVAATTERILLQPPDDQS
>NZ_CP046172.1|WP_167473719.1|3305712_3306240_-|NUDIX-hydrolase
METLGSQTMYSNPWISVREDVVRRADDSTGIYGVVDLPDFAMIIPLRNNMFHLVEQFRYPLGLRRWEFPAGSCPADDPVTAAHIELREETGLRAGRLIHLGTVDSAPSMSSQRGWIYLATDLTDGAPEREHSEQDMRSAWFLRETVEAMLTSGEITDSHTVAAYTLLLLHERRGD
>NZ_CP046172.1|WP_167479204.1|3305166_3305643_+|GNAT-family-N-acetyltransferase
MIGIRRLGPDEWATFRRLRLLSLADAPHAFGATLAEAQRRTEAGWRALLAGRVQFVATVDGAEVGTIGGLADPERDGAHLISMWVAPGARGTGVGDVLVRALVDWARGAGYRRVWLEVAEGNVVAEKLYLRNGFARTGVRSIISPANPRPEFEMMLEF
>NZ_CP046172.1|WP_167479203.1|3304650_3305079_+|SgcJ/EcaC-family-oxidoreductase
MYDNTIESGDRAALLALERAQAAAWAAGDGAAFAATCTEDVDFVSVIGEFIRGRSELAKVMQDGFDGFMKGTRWSEPREVTIRFPAPDLAVMVTNGVCVLRDGAETCRPEDLSIQTRTAVKADGSWLFTSFQNTRIRPSGPA
>NZ_CP046172.1|WP_167473725.1|3312506_3313271_+|DUF4111-domain-containing-protein
MDAASDRYAGDLASAMAAVFGSRLVGVYLHGSAVLGGFDARRSDIDVLVVCANSLTVAERSAVAVGLSEERLPCPAHGLELSVVTLPVTRHPTALPRFELHVTTAPDDSKVVDGHEHAGDPDLVLHFAVCRQAGRRIGSGRPASEVFAPVATELVLAQLVRELRWAAEHAAGEYAVLNACRAWRFAVDSTLVSKIDGGRWAMDRVPQPDRELIRTALNRQRCLPAAELSPSAVEQFVHQTLARVTSGSTCGPIA
>NZ_CP046172.1|WP_167473726.1|3316443_3317040_-|hypothetical-protein
MRVRFIRSQPAARFAHRGTGAIEVFLVSSARRQAIIHILDYLGEGIIEIGQARDTVAHYLRLLAEMPPVKDTESVRPLEVPLKLSAVRPHCISWTRGWSVEADADDLVASACDWDLGRGDPVRRDGRCSPRYRTALFSLPVSEVLRRCSCGELRRSRRIRSARRIRCRSGGRRSVPAGRPAGTNMKLATKWFMPVYSV
>NZ_CP046172.1|WP_167473727.1|3317080_3317365_-|hypothetical-protein
MIDPLALEGRREQLLARLRELRGELADLADDYGELPASGLLIDTDGIGALTTPGYCIAGAREVFEEALLELDAAGDALGRAATYTGRLRPVVFD
>NZ_CP046172.1|WP_167473728.1|3317405_3318110_-|DUF4386-family-protein
MVSKALGGPTWPFTRIGGIGAIVFATAIIGINLILFPAGLPEGRTDIADTTRFFDDNGEIVRWALAATPVAFFAVVAFGAGAFAALREFERADISAWSLVGLAGLVLQTAVFTVVSALRLALTTIPEHTSATAAGLFALHNAVFNLNGTFLATAMIGLSMGGLRARLIQPWHAALGFVAAALQFTWTLLTPLMLDRPSPLSLLGLVGWLIWTVWLVVYGITLIRLRANRIAVAY
>NZ_CP046172.1|WP_167473729.1|3318147_3318768_+|helix-turn-helix-transcriptional-regulator
MKERRRYDSLRRAAQAQQTSAAIADAARELFVTRGWAATTIREVATAAGVSVPTVYAAYGNKAGLARALVDAADLSADADRMLGELDSAAGDPAKQLAAMAGYDRRLYERSGDVIVLLREAGRAEPELAHAYREARDRADDAHRQVFAAWPKGTLRQGLDLDTALDIYAALCNIDIYRTFIDERGWTPERVQRWWAAALPRELLAE
>NZ_CP046172.1|WP_167473730.1|3318798_3319317_-|RNA-methyltransferase
MTAARLRTRPELRQQRRRRAHGCWNHLIAAPLWPKHGVNLGTLLRTCDAVGACLAVPRRPWIPDALAHGNTLRHRQCVHWIDGRVDRWLDRQRDGGSAVVGVELTDESIRLADLPPARRRTIMLLGHESDGIPPEGLERLDVAVEIPMVGTGHSLNVAVAGSLVLYKLAGLC
>NZ_CP046172.1|WP_167473731.1|3319467_3320355_-|alpha/beta-fold-hydrolase
MERVEVSFPSGGEQCAAWLYPPDGVPKPRPLVVMGHGLGGNREMGLDRYARRFAAAGMAVLVFDYRHFGASQGSPRQLVHIARQREDWHAAIAYARTLRGIDATRIALWGTSFGGGHVLAVAPDDAYIAAVVAQVPFTSGWASALAKGPISLTKVSTIAATDLLVGPLRRKPVRIRLAGRKRSAALMSASDVPEGYGRLAEESPRYEPKVAARIAFSALFDAPGRRAKALKMPVLYAVADHDSIAPAKSALRAAERTKHAIVKRYPVGHFDVYFDDHFERAVYDQIEFLVSVLRP
>NZ_CP046172.1|WP_167473732.1|3320892_3321366_+|GNAT-family-N-acetyltransferase
MIVRRLAVDEWKITREIRLDALRGSPRGTFATTYDIAAEWTDEQWRDWHRGRELFVAELDRSPVGCAGLIIQEGLPVLVSMWVNPVARGTGASDHLIDAVIARARETGHRELRLWVLKDNRHAEKLYERKGFVFTGRDQPSRMNNPRREREMIIDVA
>NZ_CP046172.1|WP_167479207.1|3321910_3322759_+|slipin-family-protein
MDILEFLASIVGIAAVGGGIATAASARVVAQYEKGLIFRFGRMVATRDPGLRLLIPFVDKMRKVSTRIVTMPVPAQEGITRDNVTVRVDAVVYFRVIDPERAVLEVENYLFAVGQVAQTSLRSIIGKSDLDDLLSNREELNKGLEIMIDSPALAWGVHIDRVEIKDVALPDAMKRSMSRQAEAERERRARVISAEGELQASDMLSRAAAQMAETPAALQLRLLETVVQVAAEKNSTLVLPFPVELLRFLERSSLPAADPKPEAPQPKSPDDTQATGPTGTQA
>NZ_CP046172.1|WP_167473733.1|3322950_3323337_-|hypothetical-protein
MIRTTAAIAACATAFALLLTGCGSDKASSSAPASAAATSAKPAAPAGLDNVKAGAFVVAFKNAFPKLADGKDDTKIAGVLSDTCTDIKAGKPEDAVVKGVGTRVKSASADATTEESQAIYQMAKLMCG

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Crispr_ID: NZ_CP046172_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046172_8

4976283-4976376

Orphan

Consensus_repeat	Method
AGCGCCTCGCACAGGAGCTCGGCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046172_8

>merge|NZ_CP046172|8|4976283-4976376|CRISPRCasFinder
AGCGCCTCGCACAGGAGCTCGGCCCGGCACAGACTGTCGTCAGGCTTCGCTCGGCAGCGCCTCCAGGCGAGCGCCTCGCACGGGAGCTCGGCCC

>NZ_CP046172|8|8|4976283-4976376|CRISPRCasFinder
AGCGCCTCGCACAGGAGCTCGGCCC	GGCACAGACTGTCGTCAGGCTTCGCTCGGCAGCGCCTCCAGGCG
AGCGCCTCGCACGGGAGCTCGGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046172.1\|WP_167479402.1\|4975152_4976073_-\|undecaprenyl-diphosphate-phosphatase	unknown	unknown	gnl\|CDD\|237134
NZ_CP046172.1\|WP_167475033.1\|4976452_4977412_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|223739
NZ_CP046172.1\|WP_167475031.1\|4973504_4974089_-\|DUF3090-domain-containing-protein	unknown	unknown	gnl\|CDD\|213872
NZ_CP046172.1\|WP_167475035.1\|4980132_4980849_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167475034.1\|4977473_4978583_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238569
NZ_CP046172.1\|WP_167475032.1\|4974161_4974917_-\|MSMEG_4193-family-putative-phosphomutase	unknown	unknown	gnl\|CDD\|163560
NZ_CP046172.1\|WP_167475038.1\|4982698_4984792_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP046172.1\|WP_167475029.1\|4970859_4971729_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366009
NZ_CP046172.1\|WP_167475025.1\|4967463_4967856_-\|DUF4440-domain-containing-protein	unknown	unknown	gnl\|CDD\|226769
NZ_CP046172.1\|WP_167475028.1\|4969398_4970637_-\|cysteine--1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside-ligase	unknown	unknown	gnl\|CDD\|183518
NZ_CP046172.1\|WP_167479404.1\|4980863_4981679_+\|heme-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|237422
NZ_CP046172.1\|WP_167475037.1\|4982277_4982628_-\|YrdB-family-protein	unknown	unknown	gnl\|CDD\|378498
NZ_CP046172.1\|WP_167475039.1\|4984793_4985333_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167475030.1\|4972700_4973501_-\|SCO1664-family-protein	unknown	unknown	gnl\|CDD\|274813
NZ_CP046172.1\|WP_167475040.1\|4985333_4985690_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369888
NZ_CP046172.1\|WP_167479403.1\|4978642_4979716_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NZ_CP046172.1\|WP_167475036.1\|4981988_4982126_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167475026.1\|4968058_4969111_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|234811
NZ_CP046172.1\|WP_167475027.1\|4969136_4969313_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167479401.1\|4964331_4967463_+\|isoleucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235681

Protein	Function_ID	Function_description	E-value
NZ_CP046172.1\|WP_167479402.1\|4975152_4976073_-\|undecaprenyl-diphosphate-phosphatase	gnl\|CDD\|237134	PRK12554, PRK12554, undecaprenyl pyrophosphate phosphatase; Reviewed.	4.03884e-110
NZ_CP046172.1\|WP_167475033.1\|4976452_4977412_+\|aldo/keto-reductase	gnl\|CDD\|223739	COG0667, Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion].	6.93754e-73
NZ_CP046172.1\|WP_167475031.1\|4973504_4974089_-\|DUF3090-domain-containing-protein	gnl\|CDD\|213872	TIGR03847, TIGR03847, conserved hypothetical protein. The conserved hypothetical protein described here occurs as part of the trio of uncharacterized proteins common in the Actinobacteria.	5.60963e-86
NZ_CP046172.1\|WP_167475034.1\|4977473_4978583_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238569	cd01149, HutB, Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains.	1.36291e-59
NZ_CP046172.1\|WP_167475032.1\|4974161_4974917_-\|MSMEG_4193-family-putative-phosphomutase	gnl\|CDD\|163560	TIGR03848, MSMEG_4193, probable phosphomutase, MSMEG_4193 family. A three-gene system broadly conserved among the Actinobacteria includes MSMEG_4193 and homologs, a subgroup among the larger phosphoglycerate mutase family protein (pfam00300). Another member of the trio is a probable kinase, related to phosphatidylinositol kinases; that context supports the hypothesis that this protein acts as a phosphomutase.	1.19466e-113
NZ_CP046172.1\|WP_167475038.1\|4982698_4984792_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	7.2439e-88
NZ_CP046172.1\|WP_167475029.1\|4970859_4971729_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|366009	pfam00296, Bac_luciferase, Luciferase-like monooxygenase.	1.88194e-28
NZ_CP046172.1\|WP_167475025.1\|4967463_4967856_-\|DUF4440-domain-containing-protein	gnl\|CDD\|226769	COG4319, COG4319, Ketosteroid isomerase homolog [Function unknown].	3.47963e-06
NZ_CP046172.1\|WP_167475028.1\|4969398_4970637_-\|cysteine--1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside-ligase	gnl\|CDD\|183518	PRK12418, PRK12418, cysteinyl-tRNA synthetase; Provisional.	0
NZ_CP046172.1\|WP_167479404.1\|4980863_4981679_+\|heme-ABC-transporter-ATP-binding-protein	gnl\|CDD\|237422	PRK13548, hmuV, hemin importer ATP-binding subunit; Provisional.	7.37446e-123
NZ_CP046172.1\|WP_167475037.1\|4982277_4982628_-\|YrdB-family-protein	gnl\|CDD\|378498	pfam10823, DUF2568, Protein of unknown function (DUF2568). One member in this family is annotated as yrdB which is part of a four gene operon however currently no function is known.	3.70642e-07
NZ_CP046172.1\|WP_167475030.1\|4972700_4973501_-\|SCO1664-family-protein	gnl\|CDD\|274813	TIGR03843, Phosphatidylinositol_3-_and_4-kinase, conserved hypothetical protein. This model represents a protein family largely restricted to the Actinobacteria (high-GC Gram-positives), although it is also found in the Chloroflexi. Distant similarity to the phosphatidylinositol 3- and 4-kinase is suggested by the matching of some members to pfam00454.	1.59989e-120
NZ_CP046172.1\|WP_167475040.1\|4985333_4985690_-\|hypothetical-protein	gnl\|CDD\|369888	pfam08458, PH_2, Plant pleckstrin homology-like region. This family describes a pleckstrin homology (PH)-like region found in several plant proteins of unknown function.	0.00164269
NZ_CP046172.1\|WP_167479403.1\|4978642_4979716_+\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	2.44731e-80
NZ_CP046172.1\|WP_167475026.1\|4968058_4969111_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|234811	PRK00685, PRK00685, metal-dependent hydrolase; Provisional.	1.70044e-07
NZ_CP046172.1\|WP_167479401.1\|4964331_4967463_+\|isoleucine--tRNA-ligase	gnl\|CDD\|235681	PRK06039, ileS, isoleucyl-tRNA synthetase; Reviewed.	0

>NZ_CP046172.1|WP_167479402.1|4975152_4976073_-|undecaprenyl-diphosphate-phosphatase
MTWVQALVLGLVQGLTEFLPISSSAHLRIVSAVCFGDDAGASFTAVTQLGTEAAVLVYFAKDIWRIVLAWFAGVGSRLRSRETVPLSDRVTTKLPVITDPREYADLDAQRELDYRIGWYVIIATIPIGVLGFLLKDQIRTGARNLWLISTMLIVFALVIAAAEYYGRKQRPIEQLTTRDGLVMGLAQCLALIPGVSRSGATSSAGLFAGLTRQAAVRFSFLLAIPAVTASGLFSIPDAFAPAGDGLNASGPQLIVATIVAFSVGYASIAWLLRFVADHSLGWFVGYRILLGLTVMGLLATGTVSAT
>NZ_CP046172.1|WP_167475032.1|4974161_4974917_-|MSMEG_4193-family-putative-phosphomutase
MTVILLRHGVSTSNTARTLAGRSAGVDLTDRGAEQARGVADRLAELPIEHIAASPLLRCQRTVAPLAEKFGLEPDYDDRLVEVDYGEWTGRPIAELLNEPLWKVVQRHASGATFPGGEGLAQVQTRAVAAIRETDRELAQRHSRDVLWVACTHGDVIKAVLADALGIHLDGFQRIVVEPASLSVVRYTPTAPYVVRLNDTGVDLSGLAIKPQRAVADSPPGRADDPGPVPGGELGAAAGADNGNAERSDSL
>NZ_CP046172.1|WP_167475031.1|4973504_4974089_-|DUF3090-domain-containing-protein
MARAIHVFRTPDRFVAGTVGEPGDRAFYLQAVQEPRVVSVLLEKQQVKVLADRMGLLLDEVARRFSAPVPPPADEVTDNAPLVTPIDAEFRVGTMGLGWDADAGAVVVELLAITETEVDESVVLDDTEEGPDAVRVFLTPVQAREFALRSARVIAAGRPPCPLCGEPLSARGHMCVRTNGYKRGDIFGAAELEE
>NZ_CP046172.1|WP_167475030.1|4972700_4973501_-|SCO1664-family-protein
MAQADDRFHSGELTVIGRVNVASNVTLVCDIEDSGGPLRVVYKPVRGERPLWDFPDGTLAGREVASYLISEALGWGVVPETILRDGPFGPGMVQRWVDAADNHTDQGDRLDLVDLCPAGAVPDGFREVLRAQDAAGNEVSLIHADDPRLQRMAVLDVLLNNADRKGGHALEGVDGQVYGVDHGICLHSEYKLRTVLWGWAGQPVCEDLIADIAAFAKALPNQLADTLSRHITDAEIDALAARARALVDRPIMPFPDTARPIPWPAF
>NZ_CP046172.1|WP_167475029.1|4970859_4971729_+|LLM-class-flavin-dependent-oxidoreductase
MTVLGAVSLPHLAPEQLAAVSDAAESSGLEELWLWEDCFWGGAIAAAATVLARTERVRVGIGVMPTPLRNVALNAMELSVLLRAHPGRLLPGVGHGVQEWMAQIGARVDSPLTLMREQLTALRALLSGEKVSVSGRYVHLDEVALAWPPSTPTPLIAAATGPKTLRLSGEFADGTILTSRTAPEGVRAAKQIIDEGVAKSGRAQPHRIIVNVDTVTGPDAADRLTRCQQGREGQQPGAGATGDAQSIADAVRRYAEAGADTVVLQPPVDDPDPIEFIRFVGAEVRPLVG
>NZ_CP046172.1|WP_167475028.1|4969398_4970637_-|cysteine--1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside-ligase
MQSWSEIALPTVPGAGPPLRLYDTADRQVRPVTPGPTATMYVCGITPYDATHLGHAATYLTFDLVNRVLRDAGHEVHYVQNVTDVDDPLFERAARDGVDWRDLGTREIELFREDMTALRIVPPRDYVGAIESVDEVVEFVQKLLASGAAYVVDDPEFPDVYFRADATEQFGYESGYDRDTMERLFAERGGDPDRPGKRDIIDALLWRAARPGEPSWPAPFGPGRPGWHIECAAIALNRIGPEFDIQGGGSDLIYPHHEYSAAHAEALVAGRRFARHYVHAGLIGLDGEKMSKSKGNLVLVSRLRRTGVDPAAIRLGLLAGHYRQDRMWTDAVLEAAQARLELWRRAVALSTGPAAADTVARLRQHLSDDLDTPKALDAVDHWARQALDYGGQDATAPADVRTAVDALLGVRL
>NZ_CP046172.1|WP_167475027.1|4969136_4969313_-|hypothetical-protein
MVGDLDVRYFGAAANGFIPMLDLTPQRVWDLMPLGVYSLPALGREFLPDTPIRVTTCP
>NZ_CP046172.1|WP_167475026.1|4968058_4969111_-|MBL-fold-metallo-hydrolase
MCTFPGRNLFGSTKTLNPAADPDAPRTVAARRRFFGDDAVDGKAGAVRADRVVLSWVGCTTYALALGGSVFLLDAWVPTLTSVGYVPATAQDLADLRPEAIFIGHGHFDHAADAGRIARACGAVVYGTAEHGTNIRAQVADSSFATVALGDASAKPGARHDFRVGAVEVTAIRHLHSAPTRRSPDGSARFFPLPDPRPVFRRPPTLDTLRHNLARLTDAEGGSLLYQFRVPGFALVWHDSSGPLTERAPEVLEILSGLPDTSVHIGAVQGFNQISNGLRDPRRYIEAIAPAVFVPAHHDNWLPGITAPAARYDSPLHAEFDRIPPGVRPELRLMHDPADYVNPGRLTFEL
>NZ_CP046172.1|WP_167475025.1|4967463_4967856_-|DUF4440-domain-containing-protein
MTIDHDAPLRAELAEFIARWVQLFNNNDLAALDELYEPDGITVPTAGNPARGQDRSAANAHLRGYGLPIQAHLRHCYPVGDIALLVVDWSMNGVTAQGYPLDLHGSAADVVRRDEHGRWRYLIDNPFGTK
>NZ_CP046172.1|WP_167479401.1|4964331_4967463_+|isoleucine--tRNA-ligase
MSPFTALPTRVELPELDARIIEWWRANDIFRRSLDRTREGASWVFYEGPPTANGAPGTHHVEARVFKDIFPRYRTMKGYAVPRQAGWDCHGLPVELAVEKELRLSGKPDIEKVGVEVFNARCRESVLRHVGEFELLTRRMGYWIDLENPYTTMSPEYVDSVWWSLKKIFDDGRLTGDFRVAPYCPRCGTALSEHEVAQGYETVTDPSVYVRFPLVEPLAGHAGAHLLIWTTTPWTLVANTAVAVHPDLTYVLVRTADGLFVVAEPLVATVLGEHAETLARFTGSALAGLAYRRPFDLVDIPGAHRIVRADYVTTTDGTGLVHQAPAFGADDLAVCRAAGFPVVNPIGGDGRFLDTVALVGGLFFKDANQVLVDDLTARGLLFEYQPFEHSYPHCWRCHTPLMYYAQPSWYIRTTGVRDAMRRENEHTTWFPDHIKHGRFGDWLANNVDWAVSRARYWGTPLPLWRCVSGHVTAIGSRAELGRLAGRDLSDLDPHRPYVDAVTFDCPDCGQTATRVPEVIDAWYDSGAMPFASLGYPYVAGSAAAFAKRYPAQYICEAIDQTRGWFYTLMAIGTLVFDRSPYENVVCLGHIMAEDGRKMSKHLGNVVAPIPLMDAHGADALRWFMACSGSPWSSRRVGPAPLDDITRRVLLTYWSTAAFFTLYASHTDWRPGTARPARDRPILDRWVLGELHTLTRAVEDRFDGYDTAGAGRLLAGFIDDLSNWYVRRSRSRFWDGEQDALSTLYECLDVLTRLLAPIVPFITEEIWQTVIRPGDPNAAESVHLADWPVADAALTGSDLAEQVAAARAAVEAGRAARKASGLRIRQPLARAYVGLPAHIRLPPELIDVIADELNVKEIGSLDTAGALTDISIKPEFRSLGRRFGKQTPAVADAIRTAPAAAVVEALREHGTAAVGAERFEIGRDDVLITETPRTGWLVETQRDTTIALDTTITAELAAEGIARDVVRAAQQARRDAGLDISDRITLTVATDDEVRDAIRQHREFVARETLADEIAFVAELSDGYRGTAGASEVLVRVERIGPAE
>NZ_CP046172.1|WP_167475033.1|4976452_4977412_+|aldo/keto-reductase
MEQRTVGRSGLRVSRIGLATHTWGSQTDADDAAGQLVAFAEAGGTLVDTSPAYAGGAAQGILGDLLTDLVPRDELVLSGCAGVTPPVEPPLDGPPPLRPTVDASRRAMLRQLDQTLADLGTDYLDIWNVAVWDPGTPLDEVAATLDAAVRSGRVRYAGVRGYCAWQLASIAALAPITAAQTQYSLLARAAELEFVPAAAHHGVGVIASAPLAGGILTGKYRDGVPADSRGADEATAAEIRHRLDERATRVVDAVVTAADGLGTSPLAVALAWIRDRPGIASMIVGARDIGQLTGVLAAETLELPRAIAAALDDVSARTE
>NZ_CP046172.1|WP_167475034.1|4977473_4978583_+|ABC-transporter-substrate-binding-protein
MSGRTAERISRGERPRTTGGSLVGTRIVKRRKGFARVVVAALAVTLALGTVACGGSNGPTADGQRGHTTAKLDSLDPVPIGPEPTPTLPVTVHSFDGSHVTVTDASRIVAVDQYGTLAQTVYALGLGQKLVGRSSRANFPAVQHVPNVAGGNGALNMESLLALRPSVFLTDTVTATPQLRDQLRATGVTTVYFDPSRTMDAVGPQIQAVAYALGVPDAGKALAQRTRDEIAAATAGIPKHDQSLKIAFLYLRSTAITFISGPNSGADALISALGATDAGTAAGLKEPFTSITSEAMIGAAPDVLLVMTDGLDSIGGVDGLAKIPGVAQTPAGRNKRVVDMSDTVLLGFGPNTGRVVAALGQAVYGGKSA
>NZ_CP046172.1|WP_167479403.1|4978642_4979716_+|iron-ABC-transporter-permease
MPGGVTPRRGIFRGRSKTTLVFAGAIIALVVLALASAAIGQVPTTPAEVAGSVLHRIGLDWGPLPAHPAGEVTLWQVRFPRVVLAILVGAALATAGALLQGVFANPLAEPGVIGVSAGAAVGAGTVIVVGGAFVAAWSVAATAFAAGLLTTLLVYLLSRSNGRTEVVTLVLTGVAINAFAGGLIAFLLFVASPAARDQIVFWQLGSLNGASWEAVGVVAVLCAGGLLAAVLIAPRLDLLALGESAARHLGVDVERLRRAVILVVAVLTTAGVAFTGIILFVGLIVPHLVRILVGPGHRVLIPLSAIVGAVVLLTADVCARSLVSNADLPLGMLTSLIGGPFFFWLLRRTRSRAGGWA
>NZ_CP046172.1|WP_167475035.1|4980132_4980849_+|hypothetical-protein
MSHDGKVGPAAAFERADGAGDIRACGAGDDDQADRVAGNGFDLIYIGKVGPAAAFECVSGADDIRAHGFGFDSSHIAEISPTVELEHVGEIRARDFGFDSDQIETINPTAELEPVGDIRAHGIEFNSDRVGRLDPTTQFQRMDGIRARDFGFDSRHIGKISPTAELQRVDDLRAHAFEFNSDHIGKLDPTAHFQRVDGIRVRDFGGGGDRRLAGARTAQVAGGGPVRGSWPIPGGGVR
>NZ_CP046172.1|WP_167479404.1|4980863_4981679_+|heme-ABC-transporter-ATP-binding-protein
MFVRSHSVPTRPERGAVTLRASGLGVERGSLRVLDGVEFAVAAGEIVALVGPNGAGKSTLLAALAGELTPSAGVVELDGRSLAHWSPLDMARRRAVLPQSHTVGFPFTAREVVAMGRAPWQRTELRERDTERIAAAMAAADVEHLATRPFPALSGGERARVALARVLAQDTGTLLLDEPTAALDLGHQESVLRLAAERAAAGAAVVVVLHDLGLAAAYADRVAVLESGRIAADGPPRQVLTTELLTRVYRHPVEVLDHPVTGAQLVLPVRR
>NZ_CP046172.1|WP_167475036.1|4981988_4982126_-|hypothetical-protein
MDSTTGLDQAERDGAAVSDPAPIGRGLQSFVQDPDGNVVELHQAA
>NZ_CP046172.1|WP_167475037.1|4982277_4982628_-|YrdB-family-protein
MRVLKGANLGLMFILEVCVLAGAIGWGCTLSAPIAVRVCAAVAAPAVFIVTWSLFGAGGGRNARYPLRGTARAALEIAWFGLAALLIGLAFSPIAGLVFFALWGVNAMLRLVWRQA
>NZ_CP046172.1|WP_167475038.1|4982698_4984792_-|MMPL-family-transporter
MLSSGSLRWGRFIHRRRYLVLAVFVLAVLASAWYGRDLSGRYTQEGWFDESSESVAASKLADSTFGRDTDSDVILLYTAPPGATVDDPAVRAAVTGSLAKLLAAHPDRILKIDSYWDSPFAGNAADATKQHAFASVGLRGSGTAVVENYLAVKPEFGAGRPGGGPGGTTVQLVGLQPVVEGINTGMQNDIHRAEVIALPIVAVLLYFVFGGVVGALLPVLIGGLTVLGTQGLMRVLTDHIEVNVFASAVVTLVSLGLAIDYGLFTVTRFREELAAGHTVEEATARTVATAGRTVLFSAAIIAISLGALFIFPNGVLRSVPYGGISSVLLAAVLSVTALPAVLSIIGHRIDFLGWKRFSRSKTEAQIDAGFFSRLALRAMRRPLLVVVPIVLGLLLLSLPLRDIEFGGISERYLSQENPARIAQERFDELFPSFRTEPLKLVVVGADSRQLGDIRDAASRIPGLTGRFDQSVPTTRGINVLQAGLVHRGDADRVIAALRAIPQPPGVRVMVAGVPALERDSINGLLHRLPLLVAILVVTALLMMWLAFRSMVLAVKAVVMSGLSLVATMGVLTWIFVEGHGAGIFHFTAGPLMFAVLALIVTVVFGLSTDYEVFLLSRMAEARENGAAAPEAIRYGIAHTGGVITSAAAILIVVTGAFGFSDLVLMKYIAYGMIAALLLDATVIRLLLTPAVLKLVWR
>NZ_CP046172.1|WP_167475039.1|4984793_4985333_-|hypothetical-protein
MVMPTTSFAMRRALPALAAALLLTAACGKGEDEASVAAARSSANASLSSSAAAASSAARHPLPTAAELDSQIKRALDPSLPDSERTALIEDGEAFRDAIPDMYKAMHDNPKAIYGVTDPVFDNHDGTLTATMRLDKDGTGANVRTTVVHFIYLDDRWKISRSDLCGILRSADYHTPACG
>NZ_CP046172.1|WP_167475040.1|4985333_4985690_-|hypothetical-protein
MKADHPSGFAIDDITVGPYAHGFGTAADGRPFAFRTVRGIVELELYRADLDIEVPGPDDIVALAQAPATDIDLDDERSVIALVRDMIPDAAVVAATADRDVTTVRALLGRISAVIDGM

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Crispr_ID: NZ_CP046172_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046172_9

5979168-5979261

Orphan

Consensus_repeat	Method
CCGGGCCGAGCTCCTGCGCGAGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046172_9

>merge|NZ_CP046172|9|5979168-5979261|CRISPRCasFinder
CCGGGCCGAGCTCCTGCGCGAGGCACTCGCCTACATTTACTGCCGGAAGTAGCCCGTCCCGCAGCCCACACCGGGCCGAGCTCCTGTGCGAGGC

>NZ_CP046172|9|9|5979168-5979261|CRISPRCasFinder
CCGGGCCGAGCTCCTGCGCGAGGC	ACTCGCCTACATTTACTGCCGGAAGTAGCCCGTCCCGCAGCCCACA
CCGGGCCGAGCTCCTGTGCGAGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046172.1\|WP_167479504.1\|5981080_5982586_-\|glycosyltransferase-family-39-protein	unknown	unknown	gnl\|CDD\|379080
NZ_CP046172.1\|WP_167475759.1\|5983340_5984252_-\|SMP-30/gluconolactonase/LRE-family-protein	unknown	unknown	gnl\|CDD\|369882
NZ_CP046172.1\|WP_167479503.1\|5976521_5977844_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|185378
NZ_CP046172.1\|WP_167475760.1\|5984313_5985558_-\|glycosyltransferase-family-1-protein	unknown	unknown	gnl\|CDD\|340817
NZ_CP046172.1\|WP_167475753.1\|5977840_5978299_-\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_CP046172.1\|WP_167479500.1\|5970381_5971161_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223673
NZ_CP046172.1\|WP_167475749.1\|5969242_5970385_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|378117
NZ_CP046172.1\|WP_167475762.1\|5986387_5987107_+\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|238194
NZ_CP046172.1\|WP_167475757.1\|5980277_5980772_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239217
NZ_CP046172.1\|WP_167475756.1\|5979873_5980251_+\|DUF488-family-protein	unknown	unknown	gnl\|CDD\|225730
NZ_CP046172.1\|WP_167479501.1\|5971172_5972021_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213260
NZ_CP046172.1\|WP_167475758.1\|5982600_5983278_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|132427
NZ_CP046172.1\|WP_167479502.1\|5972044_5972989_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223673
NZ_CP046172.1\|WP_167475761.1\|5985583_5986213_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP046172.1\|WP_167475754.1\|5978532_5979150_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_CP046172.1\|WP_167475750.1\|5972934_5973972_-\|TIGR03842-family-LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|163554
NZ_CP046172.1\|WP_167475751.1\|5973999_5975418_-\|dihydropyrimidinase	unknown	unknown	gnl\|CDD\|236240
NZ_CP046172.1\|WP_167475752.1\|5975434_5976274_-\|acyltransferase	unknown	unknown	gnl\|CDD\|143592
NZ_CP046172.1\|WP_167475755.1\|5979332_5979848_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|226489
NZ_CP046172.1\|WP_167479505.1\|5987146_5988973_-\|CocE/NonD-family-hydrolase	unknown	unknown	gnl\|CDD\|273375

Protein	Function_ID	Function_description	E-value
NZ_CP046172.1\|WP_167479504.1\|5981080_5982586_-\|glycosyltransferase-family-39-protein	gnl\|CDD\|379080	pfam13231, PMT_2, Dolichyl-phosphate-mannose-protein mannosyltransferase. This family contains members that are not captured by pfam02366.	1.19452e-14
NZ_CP046172.1\|WP_167475759.1\|5983340_5984252_-\|SMP-30/gluconolactonase/LRE-family-protein	gnl\|CDD\|369882	pfam08450, SGL, SMP-30/Gluconolaconase/LRE-like region. This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyze diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.	3.96354e-06
NZ_CP046172.1\|WP_167479503.1\|5976521_5977844_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|185378	PRK15481, PRK15481, transcriptional regulatory protein PtsJ; Provisional.	3.0697e-67
NZ_CP046172.1\|WP_167475760.1\|5984313_5985558_-\|glycosyltransferase-family-1-protein	gnl\|CDD\|340817	cd03784, GT1_Gtf-like, UDP-glycosyltransferases and similar proteins. This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.	5.03034e-48
NZ_CP046172.1\|WP_167475753.1\|5977840_5978299_-\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	5.73278e-38
NZ_CP046172.1\|WP_167479500.1\|5970381_5971161_-\|ABC-transporter-permease-subunit	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	2.64304e-44
NZ_CP046172.1\|WP_167475749.1\|5969242_5970385_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|378117	pfam09084, NMT1, NMT1/THI5 like. This family contains the NMT1 and THI5 proteins. These proteins are proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine. They are regulated by thiamine. The protein adopts a fold related to the periplasmic binding protein (PBP) family. Both pyridoxal-5'-phosphate (PLP) and an iron atom are bound to the protein suggesting numerous residues of the active site necessary for HMP-P biosynthesis. The yeast protein is a dimer and, although exceptionally using PLP as a substrate, has notable similarities with enzymes dependent on this molecule as a cofactor.	2.83034e-30
NZ_CP046172.1\|WP_167475762.1\|5986387_5987107_+\|peptidylprolyl-isomerase	gnl\|CDD\|238194	cd00317, cyclophilin, cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug cyclosporin (CsA). Immunosuppression in vertebrates is believed to be the result of the cyclophilin A-cyclosporin protein drug complex binding to and inhibiting the protein-phosphatase calcineurin. PPIase is an enzyme which accelerates protein folding by catalyzing the cis-trans isomerization of the peptide bonds preceding proline residues. Cyclophilins are a diverse family in terms of function and have been implicated in protein folding processes which depend on catalytic /chaperone-like activities. This group contains human cyclophilin 40, a co-chaperone of the hsp90 chaperone system; human cyclophilin A, a chaperone in the HIV-1 infectious process and; human cyclophilin H, a component of the U4/U6 snRNP, whose isomerization or chaperoning activities may play a role in RNA splicing. .	1.16895e-45
NZ_CP046172.1\|WP_167475757.1\|5980277_5980772_-\|NUDIX-hydrolase	gnl\|CDD\|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	1.91001e-13
NZ_CP046172.1\|WP_167475756.1\|5979873_5980251_+\|DUF488-family-protein	gnl\|CDD\|225730	COG3189, COG3189, Uncharacterized conserved protein [Function unknown].	8.66702e-41
NZ_CP046172.1\|WP_167479501.1\|5971172_5972021_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213260	cd03293, ABC_NrtD_SsuB_transporters, ATP-binding cassette domain of the nitrate and sulfonate transporters. NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	5.92291e-114
NZ_CP046172.1\|WP_167475758.1\|5982600_5983278_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|132427	TIGR03384, betaine_BetI, transcriptional repressor BetI. BetI is a DNA-binding transcriptional repressor of the bet (betaine) regulon. In sequence, it is related to TetR (pfam00440). Choline, through BetI, induces the expression of the betaine biosynthesis genes betA and betB by derepression. The choline porter gene betT is also part of this regulon in Escherichia coli. Note that a different transcriptional regulator, ArcA, controls the expression of bet regulon genes in response to oxygen, as BetA is an oxygen-dependent enzyme. [Regulatory functions, DNA interactions].	2.50713e-16
NZ_CP046172.1\|WP_167479502.1\|5972044_5972989_-\|ABC-transporter-permease-subunit	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	7.96987e-33
NZ_CP046172.1\|WP_167475761.1\|5985583_5986213_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	5.09227e-09
NZ_CP046172.1\|WP_167475754.1\|5978532_5979150_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	9.45961e-23
NZ_CP046172.1\|WP_167475750.1\|5972934_5973972_-\|TIGR03842-family-LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|163554	TIGR03842, F420_CPS_4043, F420-dependent oxidoreductase, CPS_4043 family. This model represents a family of putative F420-dependent oxidoreductases, fairly closely related to 5,10-methylenetetrahydromethanopterin reductase (mer, TIGR03555), both within the bacterial luciferase-like monoxygenase (LLM) family. A fairly deep split (to about 40 % sequence identity) in the present family separates a strictly Actinobacterial clade from an alpha/beta/gamma-proteobacterial clade, in which the member is often the only apparent F420-dependent LLM family member. The specific function, and whether Actinobacterial and Proteobacterial clades differ in function, are unknown. [Unknown function, Enzymes of unknown specificity].	0
NZ_CP046172.1\|WP_167475751.1\|5973999_5975418_-\|dihydropyrimidinase	gnl\|CDD\|236240	PRK08323, PRK08323, phenylhydantoinase; Validated.	0
NZ_CP046172.1\|WP_167475752.1\|5975434_5976274_-\|acyltransferase	gnl\|CDD\|143592	cd07568, ML_beta-AS_like, mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases). This family includes mammalian-like beta-AS (EC 3.5.1.6, also known as beta-ureidopropionase or N-carbamoyl-beta-alanine amidohydrolase). This enzyme catalyzes the third and final step in the catabolic pyrimidine catabolic pathway responsible for the degradation of uracil and thymine, the hydrolysis of N-carbamyl-beta-alanine and N-carbamyl-beta-aminoisobutyrate to the beta-amino acids, beta-alanine and beta-aminoisobutyrate respectively. This family belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 5. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. Beta-ASs from this subgroup are found in various oligomeric states, dimer (human), hexamer (calf liver), decamer (Arabidopsis and Zea mays), and in the case of Drosophila melanogaster beta-AS, as a homooctamer assembled as a left-handed helical turn, with the possibility of higher order oligomers formed by adding dimers at either end. Rat beta-AS changes its oligomeric state (hexamer, trimer, dodecamer) in response to allosteric effectors. Eukaryotic Saccharomyces kluyveri beta-AS belongs to a different superfamily.	2.27272e-167
NZ_CP046172.1\|WP_167475755.1\|5979332_5979848_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|226489	COG3981, COG3981, Predicted acetyltransferase [General function prediction only].	3.50185e-41
NZ_CP046172.1\|WP_167479505.1\|5987146_5988973_-\|CocE/NonD-family-hydrolase	gnl\|CDD\|273375	TIGR00976, Hypothetical_protein_Rv1835c/MT1883/Mb1866c., putative hydrolase, CocE/NonD family. This model represents a protein subfamily that includes the cocaine esterase CocE, several glutaryl-7-ACA acylases, and the putative diester hydrolase NonD of Streptomyces griseus (all hydrolases). This family shows extensive, low-level similarity to a family of xaa-pro dipeptidyl-peptidases, and local similarity by PSI-BLAST to many other hydrolases. [Unknown function, Enzymes of unknown specificity].	2.68706e-138

>NZ_CP046172.1|WP_167475754.1|5978532_5979150_+|class-I-SAM-dependent-methyltransferase
MSTQHSYDEIAAAYADRFQHELRGKPLDRALLDVFASEVEFTHPIADISCGPGHIARYLNDLGLFTIGVDLSPRMIEIAAATHPGIEFRTGDMRKLDLADHTFGGLVAFYSIIHVSPDDLPVAFAEFFRVLRPGAPLLLSFHIGDEVRHLDEMLGHAVDLDFHFYPRPAIESLLTAAGFEITATLERAHYPTEVATTRAYVYCRA
>NZ_CP046172.1|WP_167475753.1|5977840_5978299_-|Lrp/AsnC-family-transcriptional-regulator
MDELDSEIIGLLQADARQSNRELARRVGIAASTCLERVRTLTRRGVIRGYHAEIDPAALNRRVQAMVLVQVRPQSAAMIDSFQQAAAAFREVLSVFVLSGEHDFLLHVAVQDLDRLHGFLVDRLSKRREVAGFRSSVIFQQVHDTQPIPLEP
>NZ_CP046172.1|WP_167479503.1|5976521_5977844_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MSRRIRSGAIQPGTRLPTVREVARELRVSPATVNQAWRALAATGAIIARGRAGTFVGEPVATRISRPEGRYQRLHPPSDSAFRLDLSRGTPDARLLPDPSAALRALADAGTAGDLASNYLGDAVLPEFAAKLRADWPFRPETIAVLDGALDAVDRLLTAHVRLGDAVAVEDPCFPPFLDLLSRIGARPVPVRMDESGPLPADLAAAVTEYGVAALILQPRAQNPTGASLTARRVRDLAEILAPTGTLVIEDDHSTGIASAPLRSIGARLPGRTVHIRSYSKSHGADLRIAVAGGPARLLDPVVERRMLGPGWTSRLLQRLLLTMLDDQDAVRAVEHARAEYRRRSAELRRALARRGVQAPRADGINLWLPVAEENAAMISLAAAGIKVAPGGPFEVRDHPGSDHLRITVSPLGDHDFEWLATELAAATKALPTYRRIRRV
>NZ_CP046172.1|WP_167475752.1|5975434_5976274_-|acyltransferase
MAIVRAALVQTNWTGDKESMIKAHEDYARQAAAQGARVICFQELFYGPYFCQLQDAKFYDYAESVPGPTTERFAALAKELGLVMVLPVYEQEQPGLLYNTAAVIDADGSYLGKYRKHHIPHVSGFWEKFYFRPGNLGWPVFDTAVGRVGVYICYDRHFPEGWRALGLAGAEIVFNPSATSRGLSGYLWKLEQPASAVANEYYIGAINRVGIESDYGDDDFYGTSYFVDPEGKFVGEVGSDRDPELIVRDLDMDLIKTVRDRWAFYRDRRPDAYGPLVQP
>NZ_CP046172.1|WP_167475751.1|5973999_5975418_-|dihydropyrimidinase
MKTFIHGGTVVSATGSQPLDVLVDDETIVAVLQPGSTALGADLKANADVVIDATGKYVIPGGVDGHTHMQMPFGGTEASDTFETGTRAAAWGGTTTIIDFVVQKPGERVQDTLNLWHQKAAGQCAIDYGFHQIVGEVNDESLKGMAELVSEGVTSFKLFMAYPGVFYSDDGRILRAMQSAGDLGALLMMHAENGIAIDVLVAQSVARGDTAPYFHGTSRPWQLEEEATHRAIMLAQLTGAPLYVVHVSAKQALEQIAAARGNGQNVFGETCPQYLYLSLEEQLGAPGFEGAKWVCSTPLRSRAEGHQDALWRYIRTGDVTAVSTDHCPFCMKDQKELGIGDFSKIPNGIGGVEHRMDLMFQGVKNGWISPERWVEVCCTTPARMFGMYPRKGVISPGADADIVIYDPNGHTSIGYGKTHHMNMDHSAWEGFEIDGHVDTVLSRGRVIVDGGRYSGSTGHGRFVKRGLSQNLI
>NZ_CP046172.1|WP_167475750.1|5972934_5973972_-|TIGR03842-family-LLM-class-F420-dependent-oxidoreductase
MDIGVVLQCTPPASRVVELARIAETHGFSHVWTFDSHLLWQEPYVIYSQILAATRKVVVGPMVTNPATRDWTVTASTFATLNDMFGNRTICGIGRGDSAVRTLGGKPTTIATLRESIRVIRELGNGRAARIGDTQVRFPWAGDSRLEVWVAGYGPRALDLTGEVADGFILQLADPDITAWTIARVRAAAERAGRDPGSVKICVAAPAYVTDGTAAALDHAREQCRWFGGMVGNHVADIVAKYGAGSEIPAALTEYIAGRQGYDYNQHGRAGNTHAEFVPDAIVDRFCLLGTPDDQLARLRELEKLGVDQFAVYLQHDAKTATLEAYGESVLPRLAPPVTATEAVG
>NZ_CP046172.1|WP_167479502.1|5972044_5972989_-|ABC-transporter-permease-subunit
MGAAAARASGDRDGGGRVTLRGFGGRGARAGYAVAAFALLAALWELVKYLVPEQGLSVGGQRLLPRTTNAAMPHVWSVVTVLGERDGKSTVGATLLRTAGFTLGLALLALVLGTVVGVLLAVLMQRFAFVERGLLPYIVVSQTVPLIALAPLVAGWGGKIVIAGQPWQPWMSIAVIASYLAFFPVAVGMLRGLQAPAKASVELLHSYSASWWQTLVRLRFPAAVPHLLPALRLAAAASVIGAVVAEISTGTAGGIGRQIIVFAQQATGDAARLYAAVLAAALLGVVVTTVVALIEFALRRYSRPAGARDSGGTR
>NZ_CP046172.1|WP_167479501.1|5971172_5972021_-|ABC-transporter-ATP-binding-protein
MATTEGSTISAVAEPGDRVPAVELAHVGKIFQAGSVTALQDVSLTVAAGEFVSLIGPSGCGKSTLLRIIADLEEPTSGTVAVHGKTARRARIDQDYGIAFQQAGLLDWRTVQANVELPLELHKVPKRERRTRSAELLEMAGLTEFARRYPAELSGGMQQRVAIARALARKPSLLLMDEPFGALDEMTRERMQAELLRIAEETGAAVVFVTHSIPEAVFLSDRVVVMSPRPGRITEIVPTGWDRTDADADDIRSSTPFFDAVAAVRAALHGGHGARVAGRELR
>NZ_CP046172.1|WP_167479500.1|5970381_5971161_-|ABC-transporter-permease-subunit
MKSVLPPLIFGVAALVLWQVVTVAAGVPSFLLPSPTAIAHEFADNFDRICAAARATGANALIGLLIGAVSGIAAAVLAVRFHVIDGLLTPLAAAAAAVPIVALAPLLNSMYSTTTDTPRRMVVTIVVFFPMFVSTARGLRQVPQVHTDLMTSYAAGGWQVTRTVRLPAALPHLFTGLRIAAPGAVIAAIIAEYFGGLQNGLGSRITSAAANTAYPRAWAYVVGAMIVGLLFLAAVLILEQLTRRPRTKLGLLDNPRRSK
>NZ_CP046172.1|WP_167475749.1|5969242_5970385_-|ABC-transporter-substrate-binding-protein
MTVATKRLRACLALAAVVAATLTGCSTTESGSTTTADGLTKVRLQLQWFKQGQFAGYLAAVEKGFYKEQGLSVEILDGGTDIVPQTVLAQGQADYAVAWVPKALASREAGAGITDVAQIFQRSGTKQVSFKGESITGPAALRGKTVGNWGYGNEFELFAGMTKAGLDPAKDVKLVQQQFDMNAFLSKDIAAAQAMSYNEYAQVLETKNPATGNLYSPSDFNLIDWNDQGVAMLQDAIWANTAKLGDSKYQDQTVKFIAASLKGWAYCRDHVDECRDITVKAGSTLGASHQQWQINEVNKLIWPSPNGIGMVDKAAWDRTVKIAKETKNQDGATVLRKDPDTGAYTNEYVTKALDLLKNSGIEVTGTGYQPIQVTLTEGGK
>NZ_CP046172.1|WP_167475755.1|5979332_5979848_+|GNAT-family-N-acetyltransferase
MRTDTLRLRPLRPEDEAVVRAAQLALGQEVFTFALGLEPELGWADYLTRLEHNRRGIDLPDGMVASTFLAAVVDGEIVGRTSIRHELTDSLRRDGGHIGYAVIREHRRRGYGRAILRQSIVIARRLGIERILVTCDDSNIGSAKIIESCGGALDSVVARADGRPTRRYWID
>NZ_CP046172.1|WP_167475756.1|5979873_5980251_+|DUF488-family-protein
MDAHIGYRRVYDAVAPSDGTRVLVDRVWPRGLRRDDERLGEWLRDIAPSTELRQWYGHRPERFAEFERRYREELTRPDRRDSVRRLRELAASGPLTLVTATKDADHSQAAVLARWLTAQYRVAMP
>NZ_CP046172.1|WP_167475757.1|5980277_5980772_-|NUDIX-hydrolase
MVDQSLLRHLIAGAERDEIQRLVVGAIVEYGDCVLLLRRPESDCPGGIWEPPGGEIESGESIDRALIRAVTQETGLVAAEISTYLGQFDYPSAEDIPARQFNFVVRVTAPEPIRLRAHDAHGWLELTEEPPVTDAVKKILDRYRAIRLPLGDFARVRSATPEAG
>NZ_CP046172.1|WP_167479504.1|5981080_5982586_-|glycosyltransferase-family-39-protein
MEAMQGNTATARPPFAYLGVGVLLGLSAVALLFSSGRYGFFGDEMYFIAAGHRLSFGYADQGPVLPLLARLMDALAPGSLVALRLPAVLITLAAIVFSALIAREFGGSRTAQVLAAAAYATSPFLLLQGAQLSTNVIDSALWVPITWLLIRWVRTRHDVLLLLAGVVTAVDMQVKWLIPAFWIAVVLSVLACGPRELLGRPLLWAGGAITLAATAPTLVWQARHGWPQLGMTAQVAAEQSEIGGRILFVPIALIAAGGLGVFLLVTGLIALFRWEPLRPYRFLAPVQLLVVVAFLASNGRPYYVMGCYAAVMAAGAVWWTRKPARWRRIFSIALTVTSAAFVVFSLPLKPESELRQPDSDQAAGLQIGLYGKFGWPELRDATAAAYSALPAADREHAVIITGNYWQASALDVQRGRYGLPAIYSPNRGFGYFGTPPDTATTVLWVGGSQDDLRKHFDSVTPIGRVDSRLGFPDVTRDVTIWRCDRPHTPWSTAWPGMLNLG
>NZ_CP046172.1|WP_167475758.1|5982600_5983278_-|TetR/AcrR-family-transcriptional-regulator
MRSENGSDGQRKSFIEAARRKQIIAAAVEVISEVGYGNASLARIAERAGISKGVISYHFAGKDELMTELVVQLFVAGAEYMVPLIEAETGARNRLRVYLESNLRYIDENRKHIGAMVAVALNFRKPDGTPVFDGSNEEQDVIEPLAELLREGQRSGEFGEFDPKLMARSIRDSIDGAGSRAVRDPDFDMPGYSAHLCRVYGLATRGEAEIEEGRRGLAIREEELS
>NZ_CP046172.1|WP_167475759.1|5983340_5984252_-|SMP-30/gluconolactonase/LRE-family-protein
MRLVGRRIRALCVAAAVMAGVPAAPASGDIATGCGGWQVDTVVQGLEKLENLEPDGVGGFYLSGLESTLYHVDASGRVRTVLAHQGSGFGGLQLDGTTLYFAGLDGTFAEFDTTTGESTVLARQGGNGLLRLPGGDLLTTWVGTEGGPSQGITRYSHGTGAVQPNWASVPRAEGLALSPDRHAVYTDDLFSGEIYRVPLDAPSGWTVVGRLPGIATGPDDLTMTKAGDVFVAAHLQGAIHRFDPNTGTSCVVASGLSGGWTGPSSVRIGPDGDGWALYVTGFDGTLRRLRPPADIDLTPVPRA
>NZ_CP046172.1|WP_167475760.1|5984313_5985558_-|glycosyltransferase-family-1-protein
MAHIAIAAFGSRGDLVPLTDFGCRLREAGHDVVMTATPDLVDEIAACRLEVRPVDFAPDHEIDLDKPAKAAMELLSPKGMRRLGENLLAALADVPADVLLLSPFAELAGHPLAEARNIPSIGVRLQPLSTTSAFPPSLLGAWSAGPAVNRGAGRFATAMFDRIYGKTIAGFRDRLGLPRVAQRSLRRRRTNAEWPVLHGFSPSVVPRPGDWRPGLTVTGYWWPRRPIGWEPPGELVSFLESGSPPVFFGLGSLMLSKSQTTHVSELVRQALHTVGVRGVVQAGGAGLHVRDDTVITIGAVPHDWLFGKVATVAHSCGAGTTAAGLRAGLPTVAIPSPGGDQPFWARRLHELGVSPATLPRPKLTAERLARAIDTALTEPSHRTHAEQLATRIAEEDGAAAVVAKVEELVDKHLG
>NZ_CP046172.1|WP_167475761.1|5985583_5986213_-|TetR-family-transcriptional-regulator
MRSRGGESTFTEVARRSQIVDCAIETIAELGYHQASVRKIADRVGVAMSVVLYHFGNKDELVAAIVTECYRSVIEIMLPVVERETTAAGKLAAHIRAHTEYIATHRSHQIALTEIAANYRSRAGRRLHELTVDLAPDQRTDLAKLELEAIFERGVESNEFRSLSPVSMALAVRSAIGGALLNSTTDPDFDVRAYGEDLVTAFLLAAENR
>NZ_CP046172.1|WP_167475762.1|5986387_5987107_+|peptidylprolyl-isomerase
MSNEVRGKRNYGRIDRSSQILKGATVFAATIGAVAFAAGGAGAVERPALTGVSVPGCQDPKAGQPNGKQWPAEPALTVDQGAQYTATLETSCGTVTIALDAAKAPHTVNSFAFLSGENYFDHTRCHRLTTQGIYVLQCGDPTATGTGGPGYRFGDENLPGASYAAGTVAMANSGPDTNGSQFFLVYKDTQLPPNYTPFGKVTAGLDVLQNIANAGVQGGGADGAPAVDVSLDSVATVRN
>NZ_CP046172.1|WP_167479505.1|5987146_5988973_-|CocE/NonD-family-hydrolase
MTAQPAAWPPDTDRGDCAVEKQPDVPATMRDGTVLRADVYRPKTDQPVPVILMRTQYLKSSAQIQPSRYRAPDWFASHCYLVVIQDTRGLGKSDGVFSEFTNDQRDGYDSVEWAAQLPGSNGKVGMYGSSYVGATQWLAATETPPHLAAIVPANTSSDYYDGWNYEGGAFRLAFVEPWAMLTIGIEAAQRRGDKAAEDQLKAALTDVTSWMNFRPYKDFPPFQPTNPAVAPWFYDWIRNSTRNDYWKQWSIRDRYQNVKVPVLDMAGWYDVFLAGGVENFTGMVERGGSQEAKDNQRLVIGPWDHVGWGRKDSVIAPRLENLGPVADSPMNELMLAWYDHFLKGVDNGVAGKPRVDYYVMGANRWKSAPSWPLPQTKWTEYFFTDTGTISSAGRVGKLMPQPPTGDGSDRYRYDPADPAPSVGGHSCCGIGIGVQGPYDQTSVEQRTDVLTYTTDPLTADTEVTGPVTVKLWASSTAPDTDFVARLEVVTQDGSAVNLNNGILRAAFRDSLSDPSPIEPGKPYQFTIKIWPTSYQFKAGDRIRVAVSSSDYPQYAPNPNTGERFGDSARTQPATQTVYRDSQHPSSVVIPVIPAGDNGSDTFPLKPGR

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Crispr_ID: NZ_CP046172_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046172_10

6114360-6114439

Orphan

Consensus_repeat	Method
GAATTCGGTCACAGGCCAAGACCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046172_10

>merge|NZ_CP046172|10|6114360-6114439|CRISPRCasFinder
GAATTCGGTCACAGGCCAAGACCATCCGCGGCTCTTGCGGAATCGGCAGCTGTCCCGAATTCGGTCACAGGCCGAGACCA

>NZ_CP046172|10|10|6114360-6114439|CRISPRCasFinder
GAATTCGGTCACAGGCCAAGACCA	TCCGCGGCTCTTGCGGAATCGGCAGCTGTCCC
GAATTCGGTCACAGGCCGAGACCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046172.1\|WP_167475852.1\|6107546_6107981_-\|SgcJ/EcaC-family-oxidoreductase	unknown	unknown	gnl\|CDD\|274053
NZ_CP046172.1\|WP_167475851.1\|6106639_6107275_-\|urease-accessory-protein-UreF	unknown	unknown	gnl\|CDD\|223900
NZ_CP046172.1\|WP_167475855.1\|6111310_6111997_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP046172.1\|WP_167475864.1\|6118832_6119237_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167475850.1\|6105892_6106606_-\|urease-accessory-protein-UreG	unknown	unknown	gnl\|CDD\|349776
NZ_CP046172.1\|WP_167475861.1\|6116259_6117084_+\|DUF3097-domain-containing-protein	unknown	unknown	gnl\|CDD\|378628
NZ_CP046172.1\|WP_167475867.1\|6122358_6123078_-\|3-oxoacyl-ACP-reductase-FabG	unknown	unknown	gnl\|CDD\|187594
NZ_CP046172.1\|WP_167475866.1\|6121440_6122277_-\|enoyl-ACP-reductase-FabI	unknown	unknown	gnl\|CDD\|236124
NZ_CP046172.1\|WP_167475863.1\|6118091_6118832_+\|serine-protease	unknown	unknown	gnl\|CDD\|238113
NZ_CP046172.1\|WP_167475853.1\|6109013_6109430_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|379639
NZ_CP046172.1\|WP_167475859.1\|6114527_6115778_-\|SPFH/Band-7/PHB-domain-protein	unknown	unknown	gnl\|CDD\|223407
NZ_CP046172.1\|WP_167479516.1\|6108028_6108871_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235962
NZ_CP046172.1\|WP_167475862.1\|6117141_6117957_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167475857.1\|6113067_6113640_+\|exonuclease-domain-containing-protein	unknown	unknown	gnl\|CDD\|99836
NZ_CP046172.1\|WP_167475856.1\|6112030_6113017_+\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176206
NZ_CP046172.1\|WP_167475858.1\|6113643_6114321_-\|O-methyltransferase	unknown	unknown	gnl\|CDD\|226607
NZ_CP046172.1\|WP_167479517.1\|6119309_6120092_-\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP046172.1\|WP_167475860.1\|6115777_6116209_-\|NfeD-family-protein	unknown	unknown	gnl\|CDD\|224501
NZ_CP046172.1\|WP_167475854.1\|6109735_6111211_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|184957
NZ_CP046172.1\|WP_167475865.1\|6120398_6121493_-\|ferrochelatase	unknown	unknown	gnl\|CDD\|234585

Protein	Function_ID	Function_description	E-value
NZ_CP046172.1\|WP_167475852.1\|6107546_6107981_-\|SgcJ/EcaC-family-oxidoreductase	gnl\|CDD\|274053	TIGR02246, hypothetical_protein, conserved hypothetical protein. This family consists of uncharacterized proteins found in a number of genera and species, including Streptomyces, Xanthomonas, Oceanobacillus iheyensis, Caulobacter crescentus CB15, and Xylella fastidiosa. The function is unknown.	1.98189e-07
NZ_CP046172.1\|WP_167475851.1\|6106639_6107275_-\|urease-accessory-protein-UreF	gnl\|CDD\|223900	COG0830, UreF, Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones].	2.5057e-30
NZ_CP046172.1\|WP_167475855.1\|6111310_6111997_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	6.12029e-08
NZ_CP046172.1\|WP_167475850.1\|6105892_6106606_-\|urease-accessory-protein-UreG	gnl\|CDD\|349776	cd05540, UreG, urease accessory protein UreG. UreG is one of the four accessory proteins of urease. Urease is an enzyme which catalyzes the decomposition of urea to form ammonia and carbon dioxide. Bacterial urease is a trimer of three subunits which are encoded by genes ureA, ureB, and ureC. Up to four accessory proteins (ureD, ureE, ureF, and ureG) are required for urease catalytical function. UreG may play an important role in nickel incorporation of the urease metallocenter. UreG is a member of the Fer4_NifH superfamily which contains an ATP-binding domain. Proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.	2.5889e-112
NZ_CP046172.1\|WP_167475861.1\|6116259_6117084_+\|DUF3097-domain-containing-protein	gnl\|CDD\|378628	pfam11296, DUF3097, Protein of unknown function (DUF3097). This family of proteins with unknown function appears to be restricted to Actinobacteria.	3.55267e-160
NZ_CP046172.1\|WP_167475867.1\|6122358_6123078_-\|3-oxoacyl-ACP-reductase-FabG	gnl\|CDD\|187594	cd05333, BKR_SDR_c, beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs. This subgroup includes the Escherichai coli K12 BKR, FabG. BKR catalyzes the NADPH-dependent reduction of ACP in the first reductive step of de novo fatty acid synthesis (FAS). FAS consists of four elongation steps, which are repeated to extend the fatty acid chain through the addition of two-carbo units from malonyl acyl-carrier protein (ACP): condensation, reduction, dehydration, and a final reduction. Type II FAS, typical of plants and many bacteria, maintains these activities on discrete polypeptides, while type I FAS utilizes one or two multifunctional polypeptides. BKR resembles enoyl reductase, which catalyzes the second reduction step in FAS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet) NAD(P)(H) binding region and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H) binding pattern: TGxxxGxG in classical SDRs. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P) binding motif and an altered active site motif (YXXXN). Fungal type type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P) binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr-151 and Lys-155, and well as Asn-111 (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	3.36791e-107
NZ_CP046172.1\|WP_167475866.1\|6121440_6122277_-\|enoyl-ACP-reductase-FabI	gnl\|CDD\|236124	PRK07889, PRK07889, enoyl-[acyl-carrier-protein] reductase FabI.	1.92004e-153
NZ_CP046172.1\|WP_167475863.1\|6118091_6118832_+\|serine-protease	gnl\|CDD\|238113	cd00190, Tryp_SPc, Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.	4.00955e-43
NZ_CP046172.1\|WP_167475853.1\|6109013_6109430_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|379639	pfam14534, DUF4440, Domain of unknown function (DUF4440).	0.005193
NZ_CP046172.1\|WP_167475859.1\|6114527_6115778_-\|SPFH/Band-7/PHB-domain-protein	gnl\|CDD\|223407	COG0330, HflC, Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones].	2.09936e-65
NZ_CP046172.1\|WP_167479516.1\|6108028_6108871_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|235962	PRK07201, PRK07201, SDR family oxidoreductase.	1.75577e-101
NZ_CP046172.1\|WP_167475857.1\|6113067_6113640_+\|exonuclease-domain-containing-protein	gnl\|CDD\|99836	cd06133, ERI-1_3'hExo_like, DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins. This subfamily is composed of Caenorhabditis elegans ERI-1, human 3' exonuclease (3'hExo), Drosophila exonuclease snipper (snp), and similar proteins from eukaryotes and bacteria. These are DEDDh-type DnaQ-like 3'-5' exonucleases containing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. ERI-1 has been implicated in the degradation of small interfering RNAs (RNAi). 3'hExo participates in the degradation of histone mRNAs. Snp is a non-essential exonuclease that efficiently degrades structured RNA and DNA substrates as long as there is a minimum of 2 nucleotides in the 3' overhang to initiate degradation. Snp is not a functional homolog of either ERI-1 or 3'hExo.	3.54418e-62
NZ_CP046172.1\|WP_167475856.1\|6112030_6113017_+\|zinc-binding-dehydrogenase	gnl\|CDD\|176206	cd08244, MDR_enoyl_red, Possible enoyl reductase. Member identified as possible enoyl reductase of the MDR family. 2-enoyl thioester reductase (ETR) catalyzes the NADPH-dependent dependent conversion of trans-2-enoyl acyl carrier protein/coenzyme A (ACP/CoA) to acyl-(ACP/CoA) in fatty acid synthesis. 2-enoyl thioester reductase activity has been linked in Candida tropicalis as essential in maintaining mitiochondrial respiratory function. This ETR family is a part of the medium chain dehydrogenase/reductase family, but lack the zinc coordination sites characteristic of the alcohol dehydrogenases in this family. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. Candida tropicalis enoyl thioester reductase (Etr1p) catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis. Etr1p forms homodimers, with each subunit containing a nucleotide-binding Rossmann fold domain and a catalytic domain.	7.58003e-121
NZ_CP046172.1\|WP_167475858.1\|6113643_6114321_-\|O-methyltransferase	gnl\|CDD\|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	1.34251e-53
NZ_CP046172.1\|WP_167479517.1\|6119309_6120092_-\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	6.90436e-11
NZ_CP046172.1\|WP_167475860.1\|6115777_6116209_-\|NfeD-family-protein	gnl\|CDD\|224501	COG1585, COG1585, Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].	2.98176e-24
NZ_CP046172.1\|WP_167475854.1\|6109735_6111211_-\|MFS-transporter	gnl\|CDD\|184957	PRK14995, PRK14995, SmvA family efflux MFS transporter.	5.56277e-77
NZ_CP046172.1\|WP_167475865.1\|6120398_6121493_-\|ferrochelatase	gnl\|CDD\|234585	PRK00035, hemH, ferrochelatase; Reviewed.	5.58434e-150

>NZ_CP046172.1|WP_167475858.1|6113643_6114321_-|O-methyltransferase
MSGTEWAEVDDYVVSALVTDPETEAALQANAEAGLPPIDVSEAQGKFLELIARTAGARRVLEIGTLGGYSTIWLARAVGEKGKVITLEYQQKHAEVARENLDRAGVGERVEIRVGAALDTLPVLAQEQPEPFDLVFIDADKVNNSNYVRWALRLTRPGSVIIVDNVVRNGGVADADSDDAAIKASREVIELFGTDIGASATVLQTVGRKGWDGFIYAVVDGEPTV
>NZ_CP046172.1|WP_167475857.1|6113067_6113640_+|exonuclease-domain-containing-protein
MGMNTLLNVVDVEATCWDGPIPSGAIHEIIEIGLTVVDSAAGTRIAKHRILVRPERSTVSEFCTELTGLTQAEVDTGISFAEACRMLADEYDAHARPWASWGDYDRKQFLRQCENTGVAYPFGRRHTNAKQIFAEAYGLRRRQGMAGALHIAGLPLEGRHHCGADDAWNIAALVLDPKVRNAWRTTTFAT
>NZ_CP046172.1|WP_167475856.1|6112030_6113017_+|zinc-binding-dehydrogenase
MHAIQLHAFGPAENLRYDLVPDPQPGPGQVRIAVAAAGVHLVDTTLRAGQPGPFPLPDLPTIPGREVAGSVDRVGPDIDPAWLGKRVVAHLGAAPGGYAELAVTEAARLHEVPDGMAAADAVAMIGTGRTTLGILQFAELGPDSVAIVSAAAGGIGTLLVQYAKNAGAYVVGLAGGPAKVELVQRNGADIAADYTRDDWADTVRAALDDRRATVLFDSVGGEFARAAIDLLGKGGQRLVYGWSGSDEEPLKFSETELAARGITSEIVLGPAMLRPVGGDIRVLEDRAMAEAAAGRLRPAVQRFSLAEAAEAHRALETRATVGKVVLVP
>NZ_CP046172.1|WP_167475855.1|6111310_6111997_+|TetR/AcrR-family-transcriptional-regulator
MTESKLTRAAIVDTAITLADTEGLDALSMRRIADRMNVGAMSLYRHVANKDELLALMTDEVARQNPYPSPDGKDWTWRDRVRIAAEIDWALYQQHPWVLLTFATPRYSFGPQSLACLAWLVEGFRELNVSTREATTMSFTVWNYISGATLPHISAALMARKEMNPEGTNGLRSLLEGRSQYPVPAALADLDGAGVSDLTQEDLLFLGLTALCDGFEARAGQLTRANDS
>NZ_CP046172.1|WP_167475854.1|6109735_6111211_-|MFS-transporter
MTDLDTARSAAPTAPSSRRAWFGLAVLLLPVLLVSMDISVLFLALPTLTADLDPTAAEQLWILDIYGFLIAGLLITMGNLGDRIGRRNILLAGATVFGIASVVAALAPNPEVLIGARALMGIGGATLLPSSLALISSLFPDARERAAAIGVWTAFFAGGSAIGPVIGGLLLHQFWWGSVFLINIPVLLILLALGPFVLPEHRSGVRGPLDLPSVALSIGGILPVVYAIKHTAAEGFDPLAIVIGVIGVVVLAAFVRRQTHIDEPLLDLRLFRRAQFSVAIGSSLTGMMSLAATSYLTSIYLQSVTGRDALHAALFGIPGAVVVFLCSMFGARVGQRFGVRATFVFALSASAVGNLLLLGVGVDGGLAWYLIGSVVGGVGYGLAFTMVSDVAVSAVPPERAGSAVGISETSFELGNALGLALLGSLAALVFRSGGSYGATLGETIDAAGGNTGLIHAARESFVSGMHVAIVVGAVVLAAMAVVTWFAARAER
>NZ_CP046172.1|WP_167475853.1|6109013_6109430_-|nuclear-transport-factor-2-family-protein
MFSHDDSAVRAFILRYDANMKAGDFAALPSYFDDQLLVVTPNTARCVGRAEFLAAAEKRAGAMAWAVPRTEFAEQTVTDFGGQYWMVAARWTLSLSRSGETLDLRSDLLVRRADDGLRICAYLTRQDIGEYERATAAP
>NZ_CP046172.1|WP_167479516.1|6108028_6108871_-|SDR-family-NAD(P)-dependent-oxidoreductase
MLYPTSRPREKALRAAVSGRIVLVTGASHGIGKASARKFAAAGATVLLVARTAADLESVAAEIRADGGTAAVYPTDMTDMAAVEGLARQLLDEHGHIDVVINNAGKSIRRSIDESYDRFHDFTRTIDVNYLGPVRLMLTLLPAMRERRRGHIVNISTWGVLMPPMPKWAAYSASKAAFDVWLRSVAAEIAADGLTTSSIYMPLVHTRMSAPTDFSRMPGLTVDEASDLVCHAVVARPREIAPWWSGAVQAWSGLTRGQAQRLMERATRLTPWSGSGSASS
>NZ_CP046172.1|WP_167475852.1|6107546_6107981_-|SgcJ/EcaC-family-oxidoreductase
MNTEDELSIRSALTGQTELWIRHEMDAWGEYFTDDADFITHRGIWWRTREENVQGHKDVPESVLRQKSNYSQRIVSIDAITPDVALVHTTWTWPEHRLPGAARAEDRGGLITLIMVKRDGVWLVRAAHNTRVNGLHDFDAEAAE
>NZ_CP046172.1|WP_167475851.1|6106639_6107275_-|urease-accessory-protein-UreF
MTSLATLLALADSRLPIGGHVHSGGVEEAVASGLVRDIATVELYLRRRIETSGLVAASLAAAVCAGELDPARAEAEADARTPSPGARTASRAQGRGLLRLAKQLWPQRDWSELGVRPHLSTVFGAVGAACGVTPAELAGIVVYTTLTGAATAAQRLLALDPAAIAACTFRLTGLCDRTAAAAVTGLAALSDPLQDVLAQRHLDRAIPLFAS
>NZ_CP046172.1|WP_167475850.1|6105892_6106606_-|urease-accessory-protein-UreG
MPPHLIDGEPHDHSHDRPKRVRTPGEPLRIGIGGPVGSGKTALVAALCRQLRDELSLAVLTNDIYTTEDADFLRRHAVLPDERIAAVQTGGCPHTAIRDDITANLDAIDDLIAANPPLDLILVESGGDNLTATFSSGLIDVQIFVVDVAGGDKVPRKGGPGVTFSDLLVVNKTDLAPLVGADLGVMERDAAKVRDGRPTALISLTADPAATPVLAWVREQLRIVAEADSGAESAVAH
>NZ_CP046172.1|WP_167475859.1|6114527_6115778_-|SPFH/Band-7/PHB-domain-protein
MAVLIVAAVLVLLVVVVVFKSIALVPQAEAAVIERLGRYSRTVSGQLTFLVPFADRVRAKVDLRERVVSFPPQPVITEDNLTLHIDTVVYFQVTSPQAAVYEISNYIAAVEQLTVTTLRNVVGGMTLEQTLTSRDQINGQLRGVLDEATGRWGLRVARVELKSIDPPPSIQESMEKQMKADREKRAMILTAEGTRESQIKTAEGAKQAQILSAEGSKQAAILSAEGERQSRILRAQGERAAAYLQAQGQAKAIEKVFAAIKSGKPTPELLAYQYMQTLPLVAKGDANKVWLVPSDFGKALEGFAKSFGTQGEDGVFRYEPPTADGAETKAAEDDSEVADWFDTSSDPNIERAVRAAEASARVPVEGLVPQVPQVPNATPPQPPAQQPEAYQPPPPPAYRPEDPHGRPWQPPSGYQQ
>NZ_CP046172.1|WP_167475860.1|6115777_6116209_-|NfeD-family-protein
MAAIFFLVAGALLAAAEMLTGDFTLLMLGGGALITAGIGFGAGTPVVADAVIFAVASLLLLFVVRPVLLRRFATPPPVATNVAALTGKSGLVLERVAEHSGRIKLGGEVWTARPLDPTEEYPEGETVYVMKIDGATAVVWKGP
>NZ_CP046172.1|WP_167475861.1|6116259_6117084_+|DUF3097-domain-containing-protein
MSSRDRYGDIFSGHPRKQRRAVPTVVAERDLVVEDAATGFCGAVVGFERSYDGEFVKLEDARGAVRLFALREAAFLIDGEPVTLVRPTVRQPKQPARSASGSTRVEGLRAKVAKASRIWVEGVHDAALVERVWGHDLRVEGVVVEHLEGLDNLAERLTEFGPGPGRRVGVLVDHLVTGSKETRLSTGLGPHVLVTGHPYIDVWQAVRPSAVGIAAWPDIPRGEDWKTGVCRRLGWGTPQDGWRRVYDAVESFRDLETPLIGAVERLIDFVTEPE
>NZ_CP046172.1|WP_167475862.1|6117141_6117957_+|hypothetical-protein
MCSPSATLTVWAGSWLAGSSAPDDVLEALHAWAPKHTIAAGDPVTGGRTDLPWSSRGNLPGTGVMALLKVIRETMTEPGALLRLVLPVPGDVRGLPAGTAFAADAIDAGEGLLIGVPGAEGTGLIPQWADEDTLQWTVYSTPIPPAPGPDMSLGEAEYAMREAVRDAADALMQLHTTSVGNSDTDPRELIEAELADYARHDYPDSIPLRARRILDTADHVAAILTVAQREPASAPTSASAIVTQETLLRPLWDAIRAARLAAVHAPARGRA
>NZ_CP046172.1|WP_167475863.1|6118091_6118832_+|serine-protease
MINRRRIAAAFATAPLGLASFTAPAAAVIGGAPADAASYPWLAAIGSPLFATRADGQFCAGVLIAPDRLLTAAHCAVIAQFAPIPPAITFGRTELAAPGGDNVRVKEIRVDPDFRVSLVDGDLAFQNDLAILTLDRPLPGPIAETGAPHGDSGAVVGWGATTPDNWSNTALHTATVPIVPDDRCGTAYGPTYDPATMLCAGSTAADTGQFDSGGPLLVDGRVIAILSWGKSGDHPGVYMRIPALNF
>NZ_CP046172.1|WP_167475864.1|6118832_6119237_-|hypothetical-protein
MKTTSRRVTLAMAAAAATGTALIAGAGNAAADDWPVQQPNSPVSVFETKNFLTPSDPGYWNPFDGSYRLTSPFGTSTRIVCAGFHGVTMQCWQADQDGNPHELKKLPFNAIAGWGQPGGGPSHFVYPGYIPFIS
>NZ_CP046172.1|WP_167479517.1|6119309_6120092_-|CPBP-family-intramembrane-metalloprotease
MVVRGGVVFVAVVVWWLVLTRGVSAVFGAEYTHGLHILRALGATLVTVPLIYAARRWLDRRPWSGLEWTSFARGWRQFLFGAACWAVPAGVTAAVLLGLGWADIDPRTSLPRTLLSLAGLVVLVLLFEAIPEELIFRGYFFANLRERYSAAVTVVGQAALFTAWGVLHGSATTIDRIVLFFVFALVLGALRAKTGSLWTSIGFHAAFQVTTQFLATNHWNNIALHDPDLAMGGLAFVVAPFLATAAVLLAAQGIRGWSRS
>NZ_CP046172.1|WP_167475865.1|6120398_6121493_-|ferrochelatase
MVAPATTPGSPRISRQTEVMAYDALLLLSFGGPERPEDVMPFLENVTRGRGVPPERLAEVAQHYLHFGGVSPINALNRDIIKAVEGEFASRGIDLPVYFGNRNWHPMVEDTVERMRADGIRSALVFPTSAWGGYSGCLQYQEDIVRARASVGPDAPEMLKLRQYFDHPLLIEAFADAIRAAVAELPRDVRDAARLVFTAHSIPVRADAVAGPPGTGELYSRQVAEAARLCAAATGFDDYDLVWQSRSGPPQVPWLEPDIVDHLDRIAESGVRAVVVCPVGFVSDHLEVIWDLDNEARDRAAELGIAFARAATPGTDPRFAQLVAELVDEQLTGSAAAHLSTFESLGCTLNGAPCAIGCCGSRRE
>NZ_CP046172.1|WP_167475866.1|6121440_6122277_-|enoyl-ACP-reductase-FabI
MGGLLAGKTILITGIITDSSIAFHAAAVAQEQGAKVIITGIPERLRLIDRIAKRLPQEVPPAIGLDVTSEEDLATLAERVREHAPEGVDGVLHSIAFAPKTLMGPDAVPFLDGPGPDAAKAFEISAWSYASLARAVLPVMNEGGSIVGMDFDPRTAMPFYNWMGVAKAALESVNRYVAREVGNAKRIRSNLIAAGPIKTLAAKAIAGTATDDAAKLNQLNTYWDGASPIGWDVDDPTVVARSICALLSDWLPGTTGSIIYVDGGASHNTWFPENFSAN
>NZ_CP046172.1|WP_167475867.1|6122358_6123078_-|3-oxoacyl-ACP-reductase-FabG
MSNLTSRSVLVTGGNRGIGLAVAQRLHADGHKVAVTHRGSGAPDGLFGVKCDVTDAESIDRAFSEVEAHQGAVEVVVANAGITDNTLLMRMSEEQFSRVIDANLTGAFRVAKRANRAMLRARWGRIIFLGSVIGQMGAPGSVNYAASKAGLVGMARAITREIGSRNITANVVAPGLIDSDMTREDMTEEMRETALKVIPAGRMGQAEEVAAAISFLASDEASYITGAIIPVDGGMGMGH

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Crispr_ID: NZ_CP046172_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046172_11

6243163-6243276

Orphan

Consensus_repeat	Method
TCACAGCTCGATGGCCGCGCGCAGCTTGTCGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046172_11

>merge|NZ_CP046172|11|6243163-6243276|CRISPRCasFinder
TCACAGCTCGATGGCCGCGCGCAGCTTGTCGGCGCGCATCAGATGCGGCTTCCCACGGCAGATCGACACATCCACCCGTCCTCACAGCCCGATGGCCGCGCGCAGCTTGTCGGC

>NZ_CP046172|11|11|6243163-6243276|CRISPRCasFinder
TCACAGCTCGATGGCCGCGCGCAGCTTGTCGGC	GCGCATCAGATGCGGCTTCCCACGGCAGATCGACACATCCACCCGTCC
TCACAGCCCGATGGCCGCGCGCAGCTTGTCGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046172.1\|WP_167475977.1\|6255174_6256134_-\|aspartate-carbamoyltransferase-catalytic-subunit	unknown	unknown	gnl\|CDD\|234849
NZ_CP046172.1\|WP_167479529.1\|6256935_6257745_-\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|272862
NZ_CP046172.1\|WP_167475966.1\|6235824_6236520_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167475968.1\|6237286_6238048_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225382
NZ_CP046172.1\|WP_167475969.1\|6238280_6239369_+\|beta-lactamase-family-protein	unknown	unknown	gnl\|CDD\|365903
NZ_CP046172.1\|WP_167475975.1\|6253302_6253821_-\|transporter	unknown	unknown	unknown
NZ_CP046172.1\|WP_167475972.1\|6246032_6246314_-\|DNA-directed-RNA-polymerase-subunit-omega	unknown	unknown	gnl\|CDD\|224672
NZ_CP046172.1\|WP_167475963.1\|6233317_6233977_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379115
NZ_CP046172.1\|WP_167475974.1\|6252193_6253306_-\|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|237139
NZ_CP046172.1\|WP_167479526.1\|6231813_6233253_-\|carotenoid-oxygenase	unknown	unknown	gnl\|CDD\|226196
NZ_CP046172.1\|WP_167475973.1\|6248849_6252194_-\|carbamoyl-phosphate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|235393
NZ_CP046172.1\|WP_167475964.1\|6233986_6234565_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP046172.1\|WP_167475962.1\|6231061_6231712_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP046172.1\|WP_167479527.1\|6248014_6248839_-\|orotidine-5'-phosphate-decarboxylase	unknown	unknown	gnl\|CDD\|234651
NZ_CP046172.1\|WP_167475965.1\|6234642_6235488_+\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187578
NZ_CP046172.1\|WP_167475976.1\|6253821_6255138_-\|dihydroorotase	unknown	unknown	gnl\|CDD\|236479
NZ_CP046172.1\|WP_167471238.1\|6241367_6241745_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167479528.1\|6256130_6256694_-\|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase-PyrR	unknown	unknown	gnl\|CDD\|235365
NZ_CP046172.1\|WP_167475967.1\|6236516_6237122_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP046172.1\|WP_167475971.1\|6244745_6245993_-\|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC	unknown	unknown	gnl\|CDD\|235513

Protein	Function_ID	Function_description	E-value
NZ_CP046172.1\|WP_167475977.1\|6255174_6256134_-\|aspartate-carbamoyltransferase-catalytic-subunit	gnl\|CDD\|234849	PRK00856, pyrB, aspartate carbamoyltransferase catalytic subunit.	1.52592e-174
NZ_CP046172.1\|WP_167479529.1\|6256935_6257745_-\|SAM-dependent-methyltransferase	gnl\|CDD\|272862	TIGR00027, Hypothetical_protein_Rv0893c/MT0917/Mb0917c., methyltransferase, TIGR00027 family. This model represents a set of probable methyltransferases, about 300 amino acids long, with essentially full length homology. Members share an N-terminal region described by Pfam model pfam02409. Included are a paralogous family of 12 proteins in Mycobacterium tuberculosis, plus close homologs in related species, a family of 8 in the archaeon Methanosarcina acetivorans, and small numbers of members in other species, including plants. [Unknown function, Enzymes of unknown specificity].	2.35807e-54
NZ_CP046172.1\|WP_167475968.1\|6237286_6238048_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	9.48275e-10
NZ_CP046172.1\|WP_167475969.1\|6238280_6239369_+\|beta-lactamase-family-protein	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	5.26869e-59
NZ_CP046172.1\|WP_167475972.1\|6246032_6246314_-\|DNA-directed-RNA-polymerase-subunit-omega	gnl\|CDD\|224672	COG1758, RpoZ, DNA-directed RNA polymerase, subunit K/omega [Transcription].	1.08699e-17
NZ_CP046172.1\|WP_167475963.1\|6233317_6233977_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379115	pfam13305, WHG, WHG domain. This presumed domain is around 80 amino acids in length. It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. The domain is named WHG after three conserved residues near the C-terminus of the domain.	8.49607e-14
NZ_CP046172.1\|WP_167479526.1\|6231813_6233253_-\|carotenoid-oxygenase	gnl\|CDD\|226196	COG3670, COG3670, Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	5.56554e-139
NZ_CP046172.1\|WP_167475973.1\|6248849_6252194_-\|carbamoyl-phosphate-synthase-large-subunit	gnl\|CDD\|235393	PRK05294, carB, carbamoyl-phosphate synthase large subunit.	0
NZ_CP046172.1\|WP_167475964.1\|6233986_6234565_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	5.5227e-11
NZ_CP046172.1\|WP_167475962.1\|6231061_6231712_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	9.24625e-22
NZ_CP046172.1\|WP_167479527.1\|6248014_6248839_-\|orotidine-5'-phosphate-decarboxylase	gnl\|CDD\|234651	PRK00125, pyrF, orotidine 5'-phosphate decarboxylase; Reviewed.	1.02326e-115
NZ_CP046172.1\|WP_167475965.1\|6234642_6235488_+\|NAD(P)H-binding-protein	gnl\|CDD\|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.78935e-51
NZ_CP046172.1\|WP_167475976.1\|6253821_6255138_-\|dihydroorotase	gnl\|CDD\|236479	PRK09357, pyrC, dihydroorotase; Validated.	0
NZ_CP046172.1\|WP_167475974.1\|6252193_6253306_-\|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	gnl\|CDD\|237139	PRK12564, PRK12564, carbamoyl-phosphate synthase small subunit.	0
NZ_CP046172.1\|WP_167479528.1\|6256130_6256694_-\|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase-PyrR	gnl\|CDD\|235365	PRK05205, PRK05205, bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR.	6.47995e-85
NZ_CP046172.1\|WP_167475967.1\|6236516_6237122_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.25302e-12
NZ_CP046172.1\|WP_167475971.1\|6244745_6245993_-\|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC	gnl\|CDD\|235513	PRK05579, PRK05579, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated.	0

>NZ_CP046172.1|WP_167471238.1|6241367_6241745_-|hypothetical-protein
MSAAQQLGKRESIGGTEVRRGLLRLMRRNPRLGHRSAVPGGTGMHQEPLRASRFRREMIAAEPLGRCGPSGWIKRRYRLFRLMRRGLRSRRTMTLVWMVRELVWGSRFRRKASVVWLGDRCVFRH
>NZ_CP046172.1|WP_167475969.1|6238280_6239369_+|beta-lactamase-family-protein
MNTTGHTATVQHVLEQAVTQQNYPGAFAQIRDGESTSFLSAGVADTGSGRPAGPRDQFRVGSITKTFTATLILQLAAEYKLSLDDTVEQWLPGLVQGNGHDGRKITIRQLLNHTSGIFGYTMDERLLESHWTPELLEHRFDKFTPEELVRIAVSHPADFEPGTQWGYSNTNFVVAAMIVERASGLSYAEAIEYRISRALKLTDTYAPGSDTGFRGPHVRNYSTLMVTDPQAPIHDVTEISPSYAFGVGEIISTADDLTTFLGALLGGRILPPAQLDEMLTMTPVPDGTWLDGYSYGLGISSVMLPNGTTVYGHGGMIFGTWSYLYGTKDGHRTVAQNVNGDWGMPPMGIFIDLLDAAFTTNE
>NZ_CP046172.1|WP_167475968.1|6237286_6238048_-|helix-turn-helix-domain-containing-protein
MPGSRLTHRDRRAIAEGLAADLSYTEIAKRLDRPTSTVTREVMRNGGPNDYRPDRAQRAAQQRTRRRRNTTTAPPRTPVAHVPGRDPEAVEEFTARLTELLTGTGMPRMTAAVLSCLYTTDTGSLSSAELVDRLRVSPASISKAVGYLENQELIRRTRDAGRRDRYVIDDDVWLRATLASARMNEVLADVARDGVDVFGAATPAGARLLDMGNFLNQVCRDLIRTAEQWRHTSGSPVDLREEATWDETPSSGS
>NZ_CP046172.1|WP_167475967.1|6236516_6237122_-|TetR/AcrR-family-transcriptional-regulator
MARSVDPNRVAERRASIVRVAANLFATHGYDRTTAAQIAKAAGLSSGSVFYYFQDKAAVFRAIFESSIPEHAQLISRHIDRIDCVAAILDLVEELAAEALDPAAPGLMVELLRRIDHDPDLTAVVLEDARRSAEALTVLLRRGSDQGQLDPGFPPEETARWILAVVDAAFLNADPAHPHDPRPLVRATVSRLLRPIGTEDR
>NZ_CP046172.1|WP_167475966.1|6235824_6236520_-|hypothetical-protein
MTTSTAPTTLRLPRVWAWVFTLAGLMLGAGVGAALPPIGHWLVDTIEIAPGWLRLALTVPSVWLMPIGAAVGLIGGLILAGIAHEESLVLTVSPDHVELSQNGRERFVPRDRVAAVFREDDDLVLVDRNRMRLARFGAGDLGRGDVETAFRLHGYPWVGENDPYATEFTRWMDGRPEIDDAVHCLLRARRRAIADKKPLEVEALDEKLAEHGVDVRDRKGVQQIRLIADRT
>NZ_CP046172.1|WP_167475965.1|6234642_6235488_+|NAD(P)H-binding-protein
MIVVTGATGNIGSNLVRILAESGARVTAISRGSKDFRLPDGVRHHTADLAEPQTLAPALDGAEALFVLISGDQLIDGPAPERLLDLARAGGVRRVVFVSSLGVVTRPDADGYARLAAFEKALRASDFTWTILRPGGFYTNTYAWAESVRTARTVAAPFGDIGLPSVDPADIAAVAAAALRTDDHAGQTYTLTGPAVVTPREQSADLGAALGDSVRFVELTRDQAQAGMRQFMPAAVVEHTLSILGEPTPEELAVSIDIERILGRPATGYAEWARRNRAAFA
>NZ_CP046172.1|WP_167475964.1|6233986_6234565_-|TetR/AcrR-family-transcriptional-regulator
MANSAASSKVGKRERLAAAAAEVFHRQGVEKTTIADIARAAEVPVGNVYYYFKTKDQLVQAAIGTHERTIRGIIAELEKHATPRDRLRALVRCWVEQRGLAVEFGCPSGTLATELDKRADGLDRELAEVIRVLVDWAEEQFAAMGRADARELAVALVAAYQGISLLTNTFRDPELMRTEGARLERWIDSLAA
>NZ_CP046172.1|WP_167475963.1|6233317_6233977_+|TetR/AcrR-family-transcriptional-regulator
MVKHASRQTNTRERLLAAGLRLLEDAGPEALQARRVAAEIGASTMAVYTHFGGMTGLLESVAEEAFSRFSAAMAAVPRSDDPMADLFRVGRAYREYALANPQRYRLMFGPTAPGTPYRPGVDLTTARTPNPLRDPAFGQLLELIERMIAAGRIRADPALDVAGRLWSLTHGVVTLEITGYFGTGGNTFGQILGPAFVDLFVGMGDERARVESSLRSALA
>NZ_CP046172.1|WP_167479526.1|6231813_6233253_-|carotenoid-oxygenase
MGNRYLEGAFAPIRDEYTLTDLEVSGTIPGYLDGRYLRNGPNPVGDLDPALYHWFAGDGMVHGIRIRDGKAEWYRNRFVRGPVTSKALGEDFVVDPTTTSGVGANTNVIGHAGKTLALVEAGFAPYELDEELDTLGICDFDGTLTGGYTAHPKRDPGTGELHAVSYSFGRRNLVQYTVIGADGRARRAVDVEVTGNPMMHDFSLTEKYVVFYDLPVTFDTGLIVERMNVPRALRLPARLLLSALIGRVKLPNPPGSAEVTVPRDRRVPFRWNPKYPARVGVMPRAGGNADVRWFDIDPCFVFHPMNAYDDGETVVLDVVRYPKMFDVDRLGPNDGAPSLDRWIVDLADGKVRQTRLDDRPQEFPRIDERLVGRRYRYGYATGVTEGVAPDSVLLKHDLRGGTAVKSFGEGKHLGEFVFQPSAPDAAEDDGVLMGYVYDATTDRSDLAILDAATLETVASIHLPHRVPAGFHGNWVPTAS
>NZ_CP046172.1|WP_167475962.1|6231061_6231712_-|PadR-family-transcriptional-regulator
MENKEYPDFGRRGRRRGPGHEEWEQFARHRHGRRGFGPEFGPGFGPGFGPGFGPHFGRGRGRGGRGRRGDVRAAVLLLLAERPMHGYELIQQIRERSEDIWRPSPGSIYPALAQLEDEGLVLIEKVAGRKTAQLTEAGTEYVEAHREELGDPWADVTQDVGAQAIDLRGLIGQLMGAVAQVAAAGTPEQAEKAAEVLTEARRSLYRILAEDDTPEN
>NZ_CP046172.1|WP_167475971.1|6244745_6245993_-|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC
MTTSGAAGAATRIVVGVSGGIAAYKACSIVRRFTETGHSVRVIPTESALQFVGKATFEALSGNPVHTEVFADVPEVPHVRLGQEADLVVIAPATADLMARAASGRADDLLTATLLTARCPVLFAPAMHTEMWEHPATRANVATLRAHGAIVMEPASGRLTGTDTGPGRLPEPEEIFGLATLLLERADAIPRDLEGRRIVITAGGTREPLDPVRFLGNRSSGKQGYALARVAAQRGAHVTLIAGNTIEMAAPAAVDLVHITTAEQLKTAVDKHAVGADAVIMAAAVADFRPTNVAAAKIKKGAGEPDTIPLTKTTDILAGLVQARRDGHLTGTAIVGFAAETGDEHGDVLTHARAKLARKGCDLLVVNAVGEGKAFEVDNNDGWLLGADGTEQALDHGSKALLASRVLDALGPLLS
>NZ_CP046172.1|WP_167475972.1|6246032_6246314_-|DNA-directed-RNA-polymerase-subunit-omega
MSSTDIKTAPAYDTPVGLTNPPIDELLERTSSKYALVIYAAKRARQINDYYNQLGDGILEYVGPLVEPGLQEKPLSVAMREIHADLLEHSEGE
>NZ_CP046172.1|WP_167479527.1|6248014_6248839_-|orotidine-5'-phosphate-decarboxylase
MHTFGTRLRGAMRHFGPLCVGIDPHPGLLRAWDLTADVDGLEAFAEICVEAFDGRVALIKPQVAFFETYGSGGIAVLERTIGVLRGSGTLVLADAKRGDIGSTMDAYARAWLGDGPLGSDALTVSPYLGFGSLAPALDLADANGRGLFVLAATSNPEGAQVQRGLAADGHTIAQTMVDAAAAHNAGQEFGSVGVVVGATLTDAPDLSALNGPILMPGVGAQGGGPETIRRLLPESMLPAAVPNVSREVLAAGPSVPALRAKVDELRDQFAFLQS
>NZ_CP046172.1|WP_167475973.1|6248849_6252194_-|carbamoyl-phosphate-synthase-large-subunit
MPRREDLKHILVIGSGPIVIGQACEFDYSGTQACRVLRAEGLRVSLVNSNPATIMTDPEFADSTYVEPITPEFVEKVIEKERPDAILATLGGQTALNTAVALHERGVLEKYNVELIGADFEAIQRGEDRQKFKDIVAKVGGESARSRVCFTMDEVRETVAELGFPVVVRPSFTMGGLGSGMAYDHDDLDRIAGGGLAASPTANVLIEESILGWKEYELELMRDGRDNVVVVCSIENVDPMGVHTGDSVTVAPAMTLTDREYQRLRDLGIAILREVGVDTGGCNIQFAVNPADGRLIVIEMNPRVSRSSALASKATGFPIAKIAAKLAIGYTLDEIVNDITKETPACFEPTLDYVVVKAPRFAFEKFPGADPTLTTTMKSVGEAMSLGRNFAEALGKVLRSLETKAASFWTLSDGAWAPSNPDDPQSVSAAIEAILADLRVPTEGRIYQVERALRYGASIPDVAAASGIDPWFVAEVAGLVELRREVIDAPVLDEPLLRRAKHHGLSDRQIAALRPELAGESGVRALRHRLGVRPVFKTVDTCAAEFEAKTPYHYSAYELDPAAESEVAEQKERAKVIILGSGPNRIGQGIEFDYSCVHAAQTLSRAGYETVMVNCNPETVSTDYDTADRLYFEPLTFEDVLEVYHAECESGTVAGVIVQLGGQTPLGLAQRLTDAGVPVVGTSAAAIDLAEDRGEFGDVLVAAGLPAPKYGTATTFEQARKIAGNIGYPVLVRPSYVLGGRGMEIVYDEKSLEGYISRATELSPEHPVLVDRFLEDAIEIDVDALCDGVEVYLGGVMEHIEEAGIHSGDSACALPPITLGRSDIEAVRRSTVALAKGIGVKGLLNVQYALKDDVLYVLEANPRASRTVPFVSKATAVPLAKAAARIMLGATIAELRKEGMLPGEGDGGHVALDAPVAVKEAVLPFHRFRRADGTGVDSLLSPEMKSTGEVMGIDADFGTAFAKSQSAAYGSLPTEGTVFVSIANRDKRAMVFPVKRLHDLGFRILATEGTAEMLRRNGIPCERVRKHSEDGPADEPTIVEQIRDGEIDMVFNTPYGNSGPRVDGYEIRTAAVATNIPCITTVQGAAAAVQGIEATINGGIGVRSLQELHSVLRG
>NZ_CP046172.1|WP_167475974.1|6252193_6253306_-|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit
MTQEAALVLEDGRVFRGTAFGAVGETLGEAVFCTAMTGYQETLTDPSYHRQIVVAAAPQIGNTGWNDEDDESQKIWVAGYAVRDPARRASNWRATGTLQDELERQHVVGIAGIDTRALVRHLRTRGSMKAGIFSGAALADADELLARVNGQPSMLGADLAEEVSTDALYTIDPKGERRFTVVAVDLGIKTNTPRMFAERGMRVHVVPSNTTLDQIMELKPDGVFLSNGPGDPATQDGAVALTKGVLEKGLPLFGICFGNQILGRALGRETYKMKFGHRGINIPVVEHETGRISITAQNHGFALEGEMGERFDTPFGKAEVSHVCANDGTVEGVRLVDGRAFSVQYHPEAAAGPHDAAYLFDRFAGLMEGA
>NZ_CP046172.1|WP_167475975.1|6253302_6253821_-|transporter
MERTLWVLGLLLLFALCLFLMYLGWRNRARRQLDRIGELPTVPGDLGAQLLEPTTGLYLGSTIAPSWQDRIAVGDLGFRATAELTRFERGILLERDGATVIWIPQESITAVRTERGHAGKVMTENGVLVIRWKLPTGTEIDTGFRGDDKTVYPAWVADHSTGPASTTTGDDE
>NZ_CP046172.1|WP_167475976.1|6253821_6255138_-|dihydroorotase
MGEVLIKGARPYGEEPVDVLIRDGVIAAIGAVEAAEDAEVIEASGQILLPGFVDLHTHLREPGREDTETIETGSAAAALGGYTAVFAMANTNPVADSVVVTDHVWRRGQEVGLVDVFPVGAVTVGLAGKQLAEMGTMAAGIGRVRMFSDDGHCVYDPLIMRRALEYANSLGVLIAQHAEEPRLTIGAVAHEGPNAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASTEGTVELVKWAKAQGISITAEVTPHHLLLDDSRLETYDAVNKVNPPLREATDAAALRQALADGVIDCVATDHAPHAEQDKCCEFAAARPGMLGLETALSIIVQTMVQPGLLDWRGVARVMSERPAEIVGLDEHGRPIAVGEPGNLTLVDPEATWTVRGNELASIANNTPFEAMTFPARVTATLLRGRVTAREGKAVGDRRWDAGGP
>NZ_CP046172.1|WP_167475977.1|6255174_6256134_-|aspartate-carbamoyltransferase-catalytic-subunit
MRHLLTVTDLDRDTATQLLDEAERFEQALLGREVKKLPTLRGRTVMTVFYENSTRTRVSFEVAGKWMSADVINVSASSSSVSKGESLRDTALTLHAAGADALIVRHPASGAAHQIARWMDAWAVSSGRATGPAIINAGDGTHEHPTQALLDALTLRQRLGDIAGKRVVIVGDILHSRVARSNVFLLNTLGAEVVLVAPRTLLPVGVDAWPARVSHALDAELPGADAVLMLRVQAERMNGGFFPSAREYSVNYGLSERRLALLDEQAVVLHPGPMLRGMEIAHAVADSSKAAILQQVTNGVHMRMAVLFRLLVGTQEAIA
>NZ_CP046172.1|WP_167479528.1|6256130_6256694_-|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase-PyrR
MAAGRELLSASDVGRTIARIAHQIIEKTALDSGEPDTPRVVLIGIPTRGTTLATRLTDKIEEFAGVRPALGSLDITLYRDDLRSRPHRPLERTSVPEGGIEDALVVLVDDVLFSGRTVRSALDGLRDLGRPRAVQLAVLIDRGHRELPIRADYVGKNVPTSRSEDISVLLTETDGRDGVYLHQGDEA
>NZ_CP046172.1|WP_167479529.1|6256935_6257745_-|SAM-dependent-methyltransferase
MTAVGVAVIRARESQRPDRLYDDPLARTFVEAARAGFAETEGGVDRWSRIEAVADAFYAGRSVAVRLVDDAVRAGIESGCRQVVLIGAGLDTRAFRMPLPAGTRWFEIDLPELFAFKEPVLAAAGAVPGCVRAVIAQDLRGDWAKSLREQGFRPDEPTQWVDEGAIPYLPHEDALRVVATITELSAPGSRFGVARLKADLNQPHYHELAELVGGDPEWTPHGLGPGAEDWLREHGWRTEFRGWDEMVAGLDRPAALNDPDVGTVLAIRE

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Crispr_ID: NZ_CP046172_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046172_12

6963614-6963721

Orphan

Consensus_repeat	Method
CTCCGGCATGACCGAGCGGCTCGGCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046172_12

>merge|NZ_CP046172|12|6963614-6963721|CRISPRCasFinder
CTCCGGCATGACCGAGCGGCTCGGCTGCGCCTTTTGATCGCCCGCTGCGCTCGCTCATACCTCCGCCTCGCAGGCGCTCAGCTCCGGCATGACCGAGCGGCTCGGCTG

>NZ_CP046172|12|12|6963614-6963721|CRISPRCasFinder
CTCCGGCATGACCGAGCGGCTCGGCTG	CGCCTTTTGATCGCCCGCTGCGCTCGCTCATACCTCCGCCTCGCAGGCGCTCAG
CTCCGGCATGACCGAGCGGCTCGGCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046172.1\|WP_167479598.1\|6957324_6959115_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226715
NZ_CP046172.1\|WP_167476522.1\|6950641_6950848_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167476532.1\|6966872_6967877_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NZ_CP046172.1\|WP_167476537.1\|6972119_6972944_-\|siderophore-interacting-protein	unknown	unknown	gnl\|CDD\|99790
NZ_CP046172.1\|WP_167476539.1\|6974950_6975355_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167476528.1\|6959170_6960388_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|340883
NZ_CP046172.1\|WP_167476529.1\|6960387_6961749_-\|lysine-N(6)-hydroxylase/L-ornithine-N(5)-oxygenase-family-protein	unknown	unknown	gnl\|CDD\|226017
NZ_CP046172.1\|WP_167479599.1\|6963748_6965218_-\|aspartate-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|99743
NZ_CP046172.1\|WP_167476531.1\|6965273_6966698_-\|diaminobutyrate--2-oxoglutarate-transaminase-family-protein	unknown	unknown	gnl\|CDD\|235892
NZ_CP046172.1\|WP_167476533.1\|6967978_6968998_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NZ_CP046172.1\|WP_167476536.1\|6970792_6972025_+\|type-III-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|143510
NZ_CP046172.1\|WP_167476523.1\|6950844_6951759_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366397
NZ_CP046172.1\|WP_167476525.1\|6953337_6954366_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378890
NZ_CP046172.1\|WP_167476526.1\|6955000_6955678_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167476521.1\|6949442_6950240_+\|signal-protein	unknown	unknown	gnl\|CDD\|225837
NZ_CP046172.1\|WP_167476535.1\|6969818_6970793_+\|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
NZ_CP046172.1\|WP_167476524.1\|6951857_6952742_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
NZ_CP046172.1\|WP_167476527.1\|6955963_6957313_-\|glutamine-synthetase	unknown	unknown	gnl\|CDD\|223252
NZ_CP046172.1\|WP_167476534.1\|6968994_6969816_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
NZ_CP046172.1\|WP_167476538.1\|6973864_6974797_+\|haloalkane-dehalogenase	unknown	unknown	gnl\|CDD\|235135

Protein	Function_ID	Function_description	E-value
NZ_CP046172.1\|WP_167479598.1\|6957324_6959115_-\|hypothetical-protein	gnl\|CDD\|226715	COG4264, RhbC, Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism].	1.51264e-136
NZ_CP046172.1\|WP_167479599.1\|6963748_6965218_-\|aspartate-aminotransferase-family-protein	gnl\|CDD\|99743	cd06450, DOPA_deC_like, DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.	2.62947e-94
NZ_CP046172.1\|WP_167476532.1\|6966872_6967877_+\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	2.32829e-75
NZ_CP046172.1\|WP_167476537.1\|6972119_6972944_-\|siderophore-interacting-protein	gnl\|CDD\|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	7.88364e-72
NZ_CP046172.1\|WP_167476528.1\|6959170_6960388_-\|hypothetical-protein	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.45334e-05
NZ_CP046172.1\|WP_167476529.1\|6960387_6961749_-\|lysine-N(6)-hydroxylase/L-ornithine-N(5)-oxygenase-family-protein	gnl\|CDD\|226017	COG3486, IucD, Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism].	0
NZ_CP046172.1\|WP_167476533.1\|6967978_6968998_+\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	1.67965e-63
NZ_CP046172.1\|WP_167476531.1\|6965273_6966698_-\|diaminobutyrate--2-oxoglutarate-transaminase-family-protein	gnl\|CDD\|235892	PRK06938, PRK06938, diaminobutyrate--2-oxoglutarate aminotransferase; Provisional.	0
NZ_CP046172.1\|WP_167476523.1\|6950844_6951759_+\|hypothetical-protein	gnl\|CDD\|366397	pfam00975, Thioesterase, Thioesterase domain. Peptide synthetases are involved in the non-ribosomal synthesis of peptide antibiotics. Next to the operons encoding these enzymes, in almost all cases, are genes that encode proteins that have similarity to the type II fatty acid thioesterases of vertebrates. There are also modules within the peptide synthetases that also share this similarity. With respect to antibiotic production, thioesterases are required for the addition of the last amino acid to the peptide antibiotic, thereby forming a cyclic antibiotic. Thioesterases (non-integrated) have molecular masses of 25-29 kDa.	7.00428e-05
NZ_CP046172.1\|WP_167476525.1\|6953337_6954366_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|378890	pfam12625, Arabinose_bd, Arabinose-binding domain of AraC transcription regulator, N-term. AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].	9.22325e-32
NZ_CP046172.1\|WP_167476524.1\|6951857_6952742_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	7.50878e-23
NZ_CP046172.1\|WP_167476521.1\|6949442_6950240_+\|signal-protein	gnl\|CDD\|225837	COG3300, COG3300, MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms].	2.21702e-36
NZ_CP046172.1\|WP_167476535.1\|6969818_6970793_+\|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	1.95746e-76
NZ_CP046172.1\|WP_167476536.1\|6970792_6972025_+\|type-III-PLP-dependent-enzyme	gnl\|CDD\|143510	cd06843, PLPDE_III_PvsE_like, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE. This subfamily is composed of PvsE from Vibrio parahaemolyticus and similar proteins. PvsE is a vibrioferrin biosynthesis protein which is homologous to eukaryotic ornithine decarboxylase (ODC) and diaminopimelate decarboxylase (DapDC). ODC and DapDC are fold type III PLP-dependent enzymes that contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. It has been suggested that PvsE may be involved in the biosynthesis of the polycarboxylate siderophore vibrioferrin. It may catalyze the decarboxylation of serine to yield ethanolamine. PvsE may require homodimer formation and the presence of the PLP cofactor for activity.	4.14323e-152
NZ_CP046172.1\|WP_167476527.1\|6955963_6957313_-\|glutamine-synthetase	gnl\|CDD\|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	2.09264e-126
NZ_CP046172.1\|WP_167476534.1\|6968994_6969816_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	2.33997e-125
NZ_CP046172.1\|WP_167476538.1\|6973864_6974797_+\|haloalkane-dehalogenase	gnl\|CDD\|235135	PRK03592, PRK03592, haloalkane dehalogenase; Provisional.	1.61632e-136

>NZ_CP046172.1|WP_167476529.1|6960387_6961749_-|lysine-N(6)-hydroxylase/L-ornithine-N(5)-oxygenase-family-protein
MTSAVPDDVYDLVGVGIGPFNLALAALAEPTGLRTLFLDGRPRFAWHEGMLIDGTTLQVPFLADLVTLADPTSRWSFLNYLRTRDRLFPFVFAERWHVPRTEYDDYCRWVAESLPSCRFDARVTSCEWDGARRVFVVEHAGGRVLARNVVLGVGTEPVIPAPFADLVGERVFHTAEYRMRRESLCGATDVTVIGSGQSGGEVFLDLLRAQRDTGWRLRWLTRTPAFAPMEYSKLGLEHFTPDYIHYFRGLPDAVRERLIPQQWQLYKGMSAQTIADIYDELYDRRIGGGWADAMMCPGMEVTAAARTADGYALSCKHIQLGETFEVVTDRVLLAAGYAPRRPDFLEPLAALVDWDAQGRYRIDGDYRVTTDPSVTGGLYAQNSDMHTHGVGAPDLTLGAWRAATILNSVAGRPVAPVPATTAFTTFGPPRAGAHPSGGFGRLPSPSARPDSAR
>NZ_CP046172.1|WP_167476528.1|6959170_6960388_-|hypothetical-protein
MAAPEVVAPPDDTRAAGRRVLIGVVGLHLIGETALTPFYPELFRALFATDDLAATGTYLWVCRVIGFAALPLWGLAARRWPLHRLVFAGLCASAIFDAALGLAPNLATFTAVSAAVVATNSALLLAYPALISTYDGGDRIRGVRAYVAVFHAAMVASTLVGAAVLALPDPRWGISAFALLDGALALLCYRLLTRTGAVRTDAEQAPVRRSATLGAVVTVAALAVVFEIAGSMIRPFFVDYAVTLGATTAIAALLFLLPHAAALAAMPWTRRAHRVLGGRLLPATFVTAAVGLAVQALATEPITLTVGRLIFGVGLGLGQVALDLRMFSATGTAGPVYTVVETARVGALFVAPIAAATAASHRLGLPIAVACVLYLAAALVVPCLGGRPPGRAAEFDTDRKIPSAS
>NZ_CP046172.1|WP_167479598.1|6957324_6959115_-|hypothetical-protein
MEYPNLAPALWRRAGRALVVKMLAELAYEQVVAPVSDDAGYRLCLPGGAVYRFRARRGCFGSWRIESGSVSREFGGDTVTADDPQQLLLDLREILGLDGAVLCEAVGELIATQAADSRLLRDVLPVAELAELPYEELEAYQTGHPCLILNKGRLGFSAADIAHYTPESGRSLRLRWIAVHPELATYADVGGLTMRRLLEEELGVEQIARFRAVLTARLAEVADRTDPGDYVWLPVHPWHWDEVVQTLFAPYLADRRIIALGEAEDRLRPLQSIRTLTNVDQPRRRNTKLALLIRNTLVWRGIAAEPTRAAPVITAWVQRIRAADPFLHAESGIILLGEVASVAVAHPMFGQVPGAPYRYHELLGAVWREPVSWYLEPGQRARTMAALLYEDPHGGALVAELVRRSGLSATAWLDRFLHALLPGLLHYLCRYGIAFCPHGENTVIVYDDNEIPVRVAVKDFAEDINLLTEDLPEYADLPPAADAVLHRWAAPDLLHSIQSAIFTGHFRYLADITDRHLGVPEARFWDLVRTEVLAYQRRFPELADRFALFDLFTPTFERIALNREQLRAFGDHDRPERDGEFDLSHGVVDNPLHQRA
>NZ_CP046172.1|WP_167476527.1|6955963_6957313_-|glutamine-synthetase
MSVQIPRYSIDQLRRDIIAGSVEEVVLALPVLHGDPKGQRIAADHFLTEVIDNGLGACVYLLAADIDMRTGPGYAIDVAGAGFGDFVLRPDLATVRRLPWDDATAYVLADATWRDGTVVPVAPRRILRDQLDRLAGMGLRAFAGTELEFLVFRDSYQDAHDHGYRELRPATRYNADYALTGLDGVTPLVRDITRAMTAAGMRVETARAECHPGQYEIVFRYDDPLTTCDNHVLYKVGAKQLAAQRGAALTFMAKYDAGEGNSCHVHLSLRAEDGAAVFADPDRDGGMSRLMDHFVAGQLACMADLMLLFAPNVNSYKRLQPGSFAPVTCSWGRDDRTAPVRVLGAGHSLRLEHRVPGGDANPYLAVAAMIAAGLYGIEHELELPPPSEGGERLPSTLRAALDRWESSPVAHTLFGDDIVAHYANSARLELATFDAAVTDWERVRGFERN
>NZ_CP046172.1|WP_167476526.1|6955000_6955678_-|hypothetical-protein
MTVAAAGANAAPSRDAGPVGVVDNKLRTDVIGYRARIEGKSVALTTDSGSLSVVDDTLRVTTSDGRLVATFPMSYQRDGLKYPIAAEINGGTALLTPSTDRAGATPGEHRPVALRDIAIDPQSDKFNDAVSNFSTQSGLGVSIGALLGTVVGATVGCLGGGLFGGAALAGLTIGTLAVPGFLGGCLVTAAALGAIGAVVGTVVVGGPVAVASALLFADALGKQAG
>NZ_CP046172.1|WP_167476525.1|6953337_6954366_+|AraC-family-transcriptional-regulator
MSTEIPAPLAQLPQHRSGNGTAILVEVGAERGVPTERILRGTGLTEWDLRDTTVDIEPWQEFSAGRNLVAAAGEPGLGLIAGTRHHINSYGVWGFALISSPTVRDAIRVGLRYLALTSAFCRMTLEEDAVEARFCFDPAAIPADVRTLFVERDTAAAFTLFQEMLPGAEPLRWDFAYPAPRCVQRYQETFGVPTEFEVARTYAVLDPGLLASPLPRANERIARRYEERCRQLLDRRNPGSPLLNRIRILLLRTPDRLPSMDDVAAQLNMGTRTLRRRLTEEGTSFRGVLADFRMELAEELLRTGVTVKDVGQRLGYSDPASFHRAFRSRTGMAPGQYARRIR
>NZ_CP046172.1|WP_167476524.1|6951857_6952742_-|helix-turn-helix-transcriptional-regulator
MDTIFDSVLWDYPPGPSAPRVEFGGLRMVSMSAGHGTSASLEPAEWVHSGVECWYRVRIPLRESARVAEPRCAAIVSSVPRVGLPVSMCWDPGEDVVIVRFAPELMRSYLLSRFGRIPAEPLLFYLEVLIEHSGTESWPTLVRLVMTTRAERPESGTGGAERLLTAHLMLSPPRDRPAEPSRRSITMAPRSIRRAAELIEKHSAEPLTIADIAEAVGVGTRTIQAGFRRYLHTTPIAYLREIRLRRAHSVLLAADDRVTTVSEIATECGFAHLGRFATLYRRRYGEPPSATLRR
>NZ_CP046172.1|WP_167476523.1|6950844_6951759_+|hypothetical-protein
MNLPTDLLLPLTSDFASRTTSRHPAPTTAPMMLVQPGGFPANSFRRLAQKLAPRISLTVVDLDGIPEHRMATLTGRPCPLTVDEVAERIRAALANRGLFAAPMWLLSGWSFGGVIAYALYTALPIGERPRGLLLLDSVAPVPPYLPAGDRLPFALILPWFASYLGARSGRALDLPAQLFVRADGESGLRIVLDAALAAEALPPETTLPGLRKLFHAYVDNVLRHVRMSRMWQPRPTSGPITVVRPDRGLFGTRDALGWERLGDNVQVRWTSANHYSLLSDRVAIDAIADTALACLCGIRARMPS
>NZ_CP046172.1|WP_167476522.1|6950641_6950848_+|hypothetical-protein
MSNALDVSDAVDAASLTTARVRDRPTHEIARQLDLHPSEIDADKPFDQFGSAAIDQPARYLAGDREAR
>NZ_CP046172.1|WP_167476521.1|6949442_6950240_+|signal-protein
MHHDIHHFAMGRWLLLLAYVVSVAGSFTGLACTRRAVAAGDGPHRTRWLLIAAISIGGVGIWLMHFIAMLGFTVPGVALRYDLWWTAGSAALSISAVFIGLLVLGPTVRAGRLLIGGLITGLAVNLMHYTGMRAIRFQGRIHYDTRLVALSVLIAVVAATAALLFTLILESTPLRLIGGAVMGVAVVGMHYTGMAAVRVEVDPALPAPVGMAVFSFLFPVFVLGLLGLAVPITALLTTTPAAPSARPRSTAPSRRTSRARLPKSA
>NZ_CP046172.1|WP_167479599.1|6963748_6965218_-|aspartate-aminotransferase-family-protein
MTGGVSDTARLRQLLEAALTALDESAVLRAGPLPAGGPDAVARRIRTAVDDLVPAEGIGEIAALTRFARVMAAESVDPTDPACQAHLHCPPLAVAVAADAVASVLNPSLDSWDQAPAATVLESRLVAELAGLVGYDPNTAGGVFTSGGTESNLMGLLLAREAVLAERFGVDTVRDGLPAVVLGRMRVYTSAAAHFSMQRSVALLGLGESAVVAIPVDHRQRMDLSVLRRELGRGDTVPLVIAATAGTTDFGSIDPLPELAELARQHRTRLHVDAAYGGGALFSTRLAGLLDGIARADSIALDFHKFGWQPIAAGLFLAGRSADLAPLARQVAYLNPADDEDAGYTSLLHRSLRTSRRPDMLKVAVTLSALGRNGIGELVDACHELARYAADRIDAHDRLELTASPVLSTVVFRYRGPRYPDAAAIDAINAALRRELLATGTAIIGRTDLGAESGGVRLKFTLLNPHTTRADVDTLIAAVVAAGDREAGR
>NZ_CP046172.1|WP_167476531.1|6965273_6966698_-|diaminobutyrate--2-oxoglutarate-transaminase-family-protein
MPERSILSVSTVQPFTTSPEMAEILDRQDRRESSARTYARSFPVVPVRAKGIHIEGADGRHYLDCLSGAGTLALGHNHPVVVQALRRILDSGAPLHILDLATAEKDDFTTALYDVLPGDFARDARVHFCGPSGADAVEAALKLARTVTGRRTVLTFTGGYHGMTAGALAVTGNVAPKERVAGIASDVVRLPYPDPYRCPFGVGGAESARISAEYIERLLGDPAGGVVSPAAMILEVVQGEGGVVVADSEWLRRIRRITDDHGILLIADEVQTGVGRTGTYWAVQHSGVVPDMMVLSKAIGGSQPLAVLAYRGHYDGWAPGAHIGTFRGNTLAMAAGAATLRFVAAEGLDRRAAVLGARMLDRFRALATEFACIGDVRGRGLMIGLEFVDPDGAADACGARPAASALAAAVRAECLARGVIVELGGRHDAVLRLLPPLTVSEAELDTVFERTAEAVAAADRRYRPIADERGVRRG
>NZ_CP046172.1|WP_167476532.1|6966872_6967877_+|iron-ABC-transporter-permease
MSRMPYRTVAVLTALVACLGVAVLLSLLIGARAIDPAAALEALVRGDGSREGLVIRDIRLPRTALGVLAGAGLAVAGALLQGLTRNPLAEPGVLGVSSGAAFAVVLAIYVAGVGTPLGTAGSALLGAGVASAVVYAGYAGRGAVTPIRLALIGAALSVMLSSWSYTLMSLDKRTADEARFWLTGSLAGRPMTVSLAVAPFIVAGLVLAIALARPLNLLALGDDAATALGARPVPVRVIGGIAVALLAGGAVAGAGPIAFVGLAVPHLMRLLLGRDHRILLAGCALAGPVLLLGADIVGRILLRPMEIEAGIVTALMGAPVLIGLAIRARAGRTA
>NZ_CP046172.1|WP_167476533.1|6967978_6968998_+|iron-ABC-transporter-permease
MSTQGNAVRRPRVLRRYAAVAVCIALPLVAIWALTLGDIPIPVPDAAAAALGRGAPGDVLVVQQWRAPRVLAALVVGAALALSGALLQALLRNPLAAPDVLGVTDAAALCLVLATVAGLPAVALPPAAFAGALLAAGALVLLTHRRGLAEETTVLVGIGLHAVFAAATLFLVVRFPVEVAQQTVRWTVGTLYASAWPQAGIGLAVLAVLTPVALLLTRRLAVLQLGVDLATGLGLSVRRTRLAVTAVAVALAAVAVAIGGPVSFVALAVPQAARRLAGPLGVHTLLLSAGLGALVVLAADIAAQHAFAVVLPVGAITATVGAPIFLWLLLRSPRRRGAK
>NZ_CP046172.1|WP_167476534.1|6968994_6969816_+|ABC-transporter-ATP-binding-protein
MTNVRDDPNRALRTDGLTLAYDGREVVRELNAALPDGGFTAIIGPNGCGKSTLLRGLARLLMPRRGAAYLDGQPIHRLPTRTVARRIGLLPQSPIAPEAITVEDLVWRGRYPHRRLLRAADTADRAAVEAALTSTGLLELRGRPVDELSGGQRQRAWIALALAQQTPLLLLDEPTTYLDLRHQLDVLDLLAHLHRDAGRTVVAVLHDLDQACRYATHLVVLADGRLVAAGEPARIMTAELVEQVFDVPCEIIPDPFTGTPMVVPRPRGARGKE
>NZ_CP046172.1|WP_167476535.1|6969818_6970793_+|iron-siderophore-ABC-transporter-substrate-binding-protein
MARLRLGRRRFGLALAGVLTAGLLTGCAEAQQNPSGPSVTVEHAMGRTVVPAHPARVVVLDTPELDAVTALGVRPVGAAVVDPGTLDLPGYLRAELQGTERVGSMDEPSLEKIATLKPDLILSSKTRHEQIYPQLARIAPTVFAETPGYSWKDNFRLYAKALGKDSEADALLATYQRRATGLGSAFAAANGGVPPTVSVVRFIDGPTRLYQKKTFSGVVLSDLGVRRPPAEDVDDFSLDVGPELADKADADYVFTMSYGDPAKSQQQSFTASPLWHTLNAVRTHRVFPVSDEVWMLGIGVQGANLVLDDIARAAAVDPMRGPIR
>NZ_CP046172.1|WP_167476536.1|6970792_6972025_+|type-III-PLP-dependent-enzyme
MTIELPRSAAPLRALPATTLAAAVVERLCAADRPVNAYLYDTERAAERARRLRACLPDWAEIFYAVKANSFEPMLTALAAEVDGFEVASVREIELAGKAATAAGRTARLVAAGPAKTAPVLSALVAAGAEAVNVESVAELYRLDEAAVQAGVRMPVALRVNPDRVPVTGSLTMGGAATVFGTPESDVPEVLSVAATLPSVQVVGFHIHAVCNNLDAAAHAAYVRWCLDYSTRTAAVHGIELRLVDTGGGIGVAFGDEQPFDLDRFGDELSGIRPPDGVRVLFEPGRWPVTECGYYAAEVVDIKHAYGTWFAVLRGGINHFQLPTSWDIVHNFTVVPIEPWTHRWPRRELIDTPVTVVGELCTPEDTLARDITVDRIRIGDIVVFPNAGSYGWEFAMPEFLGHPPAPRWVL
>NZ_CP046172.1|WP_167476537.1|6972119_6972944_-|siderophore-interacting-protein
MARCTKYVKPEERQILTAEVVASKRISPNFVRVTLGGTGLACFTPMGFDQWFRLFLPGRHGLRLPSSAVGDLWWAQCRMMSEEQRPVVRNYTVREHRPAGAGQFGETAEIDIDFAMHGEHTPACGWASGATPGAPVGLLDEGIMYQVPQHCSWSLLAGDESALAAIAGALRSAPRDQHGAAYIEIAHPDDSQDLGEPEGVQVNWLVRDDPHAPVGSMALDVVRAADLPSQGVYGFVAGEQKLAGGVRRHLVADRGIPKADVTFTGYWRFGRSVD
>NZ_CP046172.1|WP_167476538.1|6973864_6974797_+|haloalkane-dehalogenase
MAAVAVLDSFMHYTDTGFGDTPVVFLHGNPTSSYLWRNVIPYIADHTRCLAPDLIGMGASGKPDIEYRFADHARYLDAWFEGLGIDRAVIVGHDWGGALGMDWAARHPGRVRGVALVETFLRPMHSDDLSAPMARIFGRLRGPEGERMVLADNMFIESDLAAVPGLSAADLEIYRAPYPTPESRRPMLAWAREYPLDGEPADVVQRVFDYDYWMDRTPEVPKLVLAGMNSATDLGSPKVIGWARAYFANVEVESIGPAGHHAPEYQPDAIGSVLARWLHRHALTPAGIDLGSWMNGFGPLTYSNLDLPPC
>NZ_CP046172.1|WP_167476539.1|6974950_6975355_+|hypothetical-protein
MDVEFADVRGRTECPASYGVRTRQGAFTIWNQQQGPESLLTTRIRGLSIGRADRPARGSGVFISGGGDERFGTRGRVEADLVELGEIYIDGGIATGARNLITSVASLRPESWPVRLPGAGQGRHPGGGLRTAHL

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Crispr_ID: NZ_CP046172_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046172_13

7376085-7376187

Orphan

Consensus_repeat	Method
CGCTCACGACTGCGCCTCGCTGACGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046172_13

>merge|NZ_CP046172|13|7376085-7376187|CRISPRCasFinder
CGCTCACGACTGCGCCTCGCTGACGCTCGGCTCCGTCGCGAGCGAGGCTGCTGTGCCTATGGTTCGCTCGCTACGCTCGCTCACGACTGCGCCTCGCCGACGC

>NZ_CP046172|13|13|7376085-7376187|CRISPRCasFinder
CGCTCACGACTGCGCCTCGCTGACGC	TCGGCTCCGTCGCGAGCGAGGCTGCTGTGCCTATGGTTCGCTCGCTACGCT
CGCTCACGACTGCGCCTCGCCGACGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046172.1\|WP_167479640.1\|7368300_7368924_-\|ANTAR-domain-containing-protein	unknown	unknown	gnl\|CDD\|377145
NZ_CP046172.1\|WP_167476829.1\|7376474_7376732_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377212
NZ_CP046172.1\|WP_167476822.1\|7370040_7370985_-\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|377085
NZ_CP046172.1\|WP_167476825.1\|7372962_7374765_-\|NADH-dehydrogenase	unknown	unknown	gnl\|CDD\|223724
NZ_CP046172.1\|WP_167476826.1\|7374764_7375112_-\|dehydrogenase	unknown	unknown	gnl\|CDD\|236258
NZ_CP046172.1\|WP_167476820.1\|7369037_7369646_-\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223728
NZ_CP046172.1\|WP_167476834.1\|7387330_7388284_+\|TIGR03557-family-F420-dependent-LLM-class-oxidoreductase	unknown	unknown	gnl\|CDD\|274645
NZ_CP046172.1\|WP_167476835.1\|7388289_7390428_-\|catalase	unknown	unknown	gnl\|CDD\|236886
NZ_CP046172.1\|WP_167479642.1\|7377213_7377780_-\|hemerythrin-domain-containing-protein	unknown	unknown	gnl\|CDD\|376622
NZ_CP046172.1\|WP_167479643.1\|7383724_7384288_-\|superoxide-dismutase-family-protein	unknown	unknown	gnl\|CDD\|376292
NZ_CP046172.1\|WP_167476833.1\|7385477_7387289_-\|glycoside-hydrolase-family-15-protein	unknown	unknown	gnl\|CDD\|366266
NZ_CP046172.1\|WP_167476824.1\|7371450_7372962_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|239559
NZ_CP046172.1\|WP_167476821.1\|7369783_7369990_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167476831.1\|7379735_7382606_+\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|223354
NZ_CP046172.1\|WP_167476832.1\|7382602_7383709_+\|mandelate-racemase	unknown	unknown	gnl\|CDD\|239444
NZ_CP046172.1\|WP_167476836.1\|7390433_7391000_-\|hemerythrin-domain-containing-protein	unknown	unknown	gnl\|CDD\|213983
NZ_CP046172.1\|WP_167476823.1\|7371092_7371335_-\|CsbD-family-protein	unknown	unknown	gnl\|CDD\|283241
NZ_CP046172.1\|WP_167476830.1\|7376731_7377217_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376653
NZ_CP046172.1\|WP_167476819.1\|7367066_7368260_-\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|279875
NZ_CP046172.1\|WP_167479641.1\|7375108_7375852_-\|sodium:proton-antiporter	unknown	unknown	gnl\|CDD\|237140

Protein	Function_ID	Function_description	E-value
NZ_CP046172.1\|WP_167479640.1\|7368300_7368924_-\|ANTAR-domain-containing-protein	gnl\|CDD\|377145	pfam03861, ANTAR, ANTAR domain. ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.	1.24325e-16
NZ_CP046172.1\|WP_167476829.1\|7376474_7376732_-\|hypothetical-protein	gnl\|CDD\|377212	pfam04066, MrpF_PhaF, Multiple resistance and pH regulation protein F (MrpF / PhaF). Members of the PhaF / MrpF family are predicted to be an integral membrane proteins with three transmembrane regions, involved in regulation of pH. PhaF is part of a potassium efflux system involved in pH regulation. It is also involved in symbiosis in Rhizobium meliloti. MrpF is part of a Na+/H+ antiporter complex, also involved in pH homeostasis. MrpF is thought to be an efflux system for Na+ and cholate. The Mrp system in Bacilli may also have primary energisation capacities.	0.000195764
NZ_CP046172.1\|WP_167476822.1\|7370040_7370985_-\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	6.02857e-55
NZ_CP046172.1\|WP_167476825.1\|7372962_7374765_-\|NADH-dehydrogenase	gnl\|CDD\|223724	COG0651, HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism].	6.09311e-71
NZ_CP046172.1\|WP_167476826.1\|7374764_7375112_-\|dehydrogenase	gnl\|CDD\|236258	PRK08389, PRK08389, putative monovalent cation/H+ antiporter subunit C; Reviewed.	3.95677e-16
NZ_CP046172.1\|WP_167476820.1\|7369037_7369646_-\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	1.10527e-10
NZ_CP046172.1\|WP_167476834.1\|7387330_7388284_+\|TIGR03557-family-F420-dependent-LLM-class-oxidoreductase	gnl\|CDD\|274645	TIGR03557, F420_G6P_family, F420-dependent oxidoreductase, G6PDH family. Members of this protein family include F420-dependent glucose-6-phosphate dehydrogenases (TIGR03554) and related proteins. All members of this family come from species that synthesize coenzyme F420, with the exception of those that belong to TIGR03885, a clade within this family in which cofactor binding may instead be directed to FMN. [Unknown function, Enzymes of unknown specificity].	8.91074e-174
NZ_CP046172.1\|WP_167476835.1\|7388289_7390428_-\|catalase	gnl\|CDD\|236886	PRK11249, katE, hydroperoxidase II; Provisional.	0
NZ_CP046172.1\|WP_167479642.1\|7377213_7377780_-\|hemerythrin-domain-containing-protein	gnl\|CDD\|376622	pfam01814, Hemerythrin, Hemerythrin HHE cation binding domain. Iteration of the HHE family found it to be related to Hemerythrin. It also demonstrated that what has been described as a single domain in fact consists of two cation binding domains. Members of this family occur all across nature and are involved in a variety of processes. For instance, in Nereis diversicolor hemerythrin binds Cadmium so as to protect the organism from toxicity. However Hemerythrin is classically described as Oxygen-binding through two attached Fe2+ ions. And the bacterial NorA is a regulator of response to NO, which suggests yet another set-up for its metal ligands. In Staphylococcus aureus the iron-sulfur cluster repair protein ScdA has been noted to be important when the organism switches to living in environments with low oxygen concentrations; perhaps this protein acts as an oxygen store or scavenger.	1.77534e-08
NZ_CP046172.1\|WP_167479643.1\|7383724_7384288_-\|superoxide-dismutase-family-protein	gnl\|CDD\|376292	pfam00080, Sod_Cu, Copper/zinc superoxide dismutase (SODC). superoxide dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the human SOD1 gene cause familial amyotrophic lateral sclerosis (Lou Gehrig's disease). Structure is an eight-stranded beta sandwich, similar to the immunoglobulin fold.	1.95637e-08
NZ_CP046172.1\|WP_167476833.1\|7385477_7387289_-\|glycoside-hydrolase-family-15-protein	gnl\|CDD\|366266	pfam00723, Glyco_hydro_15, Glycosyl hydrolases family 15. In higher organisms this family is represented by phosphorylase kinase subunits.	4.17169e-34
NZ_CP046172.1\|WP_167476824.1\|7371450_7372962_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|239559	cd03477, Rieske_YhfW_C, YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. It is commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes. YhfW is found in bacteria, some eukaryotes and archaea.	2.87167e-32
NZ_CP046172.1\|WP_167476831.1\|7379735_7382606_+\|FAD-binding-protein	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	9.67638e-73
NZ_CP046172.1\|WP_167476832.1\|7382602_7383709_+\|mandelate-racemase	gnl\|CDD\|239444	cd03328, MR_like_3, Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues, a Lys-X-Lys motif and a conserved histidine-aspartate dyad. This subgroup's function is unknown.	4.43224e-144
NZ_CP046172.1\|WP_167476836.1\|7390433_7391000_-\|hemerythrin-domain-containing-protein	gnl\|CDD\|213983	cd12108, Hr-like, Hemerythrin-like domain. Hemerythrin (Hr) like domains have the same four alpha helix bundle and a similar, but slightly different active site structure than hemerythrin. They are non-heme diiron binding proteins mainly found in bacteria and eukaryotes. Like Hr, they may be involved in oxygen transport or like human FBXL5 (F-box and leucine-rich repeat protein 5), a member of this group, play a role in cellular iron homeostasis.	5.74391e-08
NZ_CP046172.1\|WP_167476823.1\|7371092_7371335_-\|CsbD-family-protein	gnl\|CDD\|283241	pfam05532, CsbD, CsbD-like. CsbD is a bacterial general stress response protein. It's expression is mediated by sigma-B, an alternative sigma factor. The role of CsbD in stress response is unclear.	8.81164e-05
NZ_CP046172.1\|WP_167476830.1\|7376731_7377217_-\|hypothetical-protein	gnl\|CDD\|376653	pfam01899, MNHE, Na+/H+ ion antiporter subunit. Subunit of a Na+/H+ Prokaryotic antiporter complex.	8.26326e-05
NZ_CP046172.1\|WP_167476819.1\|7367066_7368260_-\|AI-2E-family-transporter	gnl\|CDD\|279875	pfam01594, AI-2E_transport, AI-2E family transporter. This family includes four different proteins from E. coli alone. One of them, YdgG or TqsA, has been shown to mediate transport of the quorum-sensing signal autoinducer 2 (AI-2). It is not clear if TqsA enhances secretion of AI-2 or inhibits AI-2 uptake. By altering the intracellular concentration of AI-2, TqsA affects gene expression in biofilms and biofilm formation. TsqA belongs to the AI-2 exporter (AI-2E) superfamily.	3.59597e-48
NZ_CP046172.1\|WP_167479641.1\|7375108_7375852_-\|sodium:proton-antiporter	gnl\|CDD\|237140	PRK12567, PRK12567, putative monovalent cation/H+ antiporter subunit B; Reviewed.	1.28337e-30

>NZ_CP046172.1|WP_167479641.1|7375108_7375852_-|sodium:proton-antiporter
MRWSVRLIVFLAGAAGIAVLLGLAVVRLPEFGAREHPYRDATVAVAQRQHAPNVVSSINFDQRGFDTVGEEAILVAAVVGAATLLRLDRDESEEVSRATEKPRLLAATKLSGYLLLPVTLLVGADVVVHGHLTPGGGFQGGVVLATGIHLLYVAGDYPALRRMRPLPWYEFGESGGMGAVVLLGIAGVLSGAGFLANVLPLGSTGQLASAGTVPVFSIAVGLAVGSGMIVLLAQFFRQYLSATGESR
>NZ_CP046172.1|WP_167476826.1|7374764_7375112_-|dehydrogenase
MTVFPYVVAVWLLLFGILGVVRSRHLVHTVVCVSIAQSSTYVLLLAIGYQRGATAPIFGSANPPGSPVVDPVVQAMALTDIVVSATVTALLLALVIQTAKRHGTVVPDELHALRG
>NZ_CP046172.1|WP_167476825.1|7372962_7374765_-|NADH-dehydrogenase
MSADSLAPLIITLPIGGACALLALGRLLPRAAIDSIALAAAVAVTALAVLLVRATGGGAVVTWAGGWRPAPGATVGIVLVADRLSAVLVLLITGLTTVALLFGWHYFDNLRAHYPALVLLFTAGMTGFALTGDLFDMFVFFELMSVAAYALTGMEVEDPESVQGGLNFGVINSLGAYLCLFGIGLLYAHTGQLGLPQLGVALAGQHRDLLALIAFGLIATGWLVKAAAAPFHFWLADAHAVAPAPVCVLFSGVMAPLGVYGLARIYWSAFDVVLPRPGVHRMIMVLAVATALLGTVMCLLQRHIKRLLAYSTIAHIGLFLLGVGSLSAAGVASATLYLAGHAAVKGALFLLAGILLSHYSSLDEHRLYHRGSRHRVLGALFVLAALLLAGLPISGAGLGKALLEESAGSMWSIALVVLVSALTGGAVLRAGLRIYFGSGAKPSAQSAADETTGAHEHPDTETPRGRVPATMFASICALLLVALALGFPSALTTAIGSAATEFTEPTGYRAAALLGTTPATAAGTHIEWSTGGVLLGGLSTVLAVLVAALALYGRKLLPDTPARLSAVIGALHRAHSGHLGDYAAWLLFGAAAVTGLLMTG
>NZ_CP046172.1|WP_167476824.1|7371450_7372962_+|FAD-dependent-oxidoreductase
MTPLWLTDVSTPARLRVTPGLRFDTVVIGGGLTGLVTALLLAENGIEVAVVEARRIGAGTTGASTAKVSLLQGIRAQQIRRHRSGDTLRAYLDANLAAQRWIVDYCDTRGVPFQRADAFTYAQSESEIDSARAEYEVLRAAGVPVEFVERLDVPFPAHGAVRLADQVQLDPMTLLAALAADIEAHAAPIYESSPVRSVRNGADGDFVIGTEHAELRAGAIVLATGTPILDRGGFFARLVPQRSYLTAFRVAEPIPHGMYISAGEPTRSLRYTPAADGAILLVGGNGHVVGRATNTAELMDDLVAWTRRWFPTAEPVTAWSAQDYAPADELPYIGPLLPGNDGIRLGTGYAKWGMTNGVAAALALAGHSIGKTPEWAGALASWRPAEVKALPAVISANASVAQQFSKGWLCAGRADAQPPAEGCGRIERHLPHPTAVATVDGTATEVSAVCPHLYGIVRWNSAEKSWDCPLHGSRFAADGTLLEGPATRSLPQVCPPIPVLEHR
>NZ_CP046172.1|WP_167476823.1|7371092_7371335_-|CsbD-family-protein
MSEHRSGPREGIEGVVEDVKGKAKEAAGIVTGDEGLEGEGRAQQDKAASQRAAAAKEAAAEKARTQADIDEQRERARQGR
>NZ_CP046172.1|WP_167476822.1|7370040_7370985_-|YihY/virulence-factor-BrkB-family-protein
MARRRISNPVQLRWRTWRGVLGRTLMAVWSDELTDWAAALTYYSVLSLFPGLLLLTSLLGLLGHGATDSLIDTVHRLGPGSGTALMVDAINELHGARSLSGPLAIAGFGTAVWTSSGYVGAFIRAANSLYEVCEGRSIWKTLPLRFGLTAAMVVLVAACAIGVVVTGDLARGVGRWLGIGSAGVWLWEVLKWPVLALLVSVVCAVLYWVAPNVRQPGFRWLTPGSVLAVLVWIAASAGFAVYVANFGSYNRVYGSLAAAVIFLVWLWLTNLAVLLGAKFDAELVRGRGIEEGRPPDHKPVLPPRDLPETGSATA
>NZ_CP046172.1|WP_167476821.1|7369783_7369990_+|hypothetical-protein
MPDPKNPGQFGNRPDTQEQASKGGKASSGSFGSENAADPHEAGRKGAEAQPTEAKQKGGQHSHSGSQS
>NZ_CP046172.1|WP_167476820.1|7369037_7369646_-|NAD(P)H-dependent-oxidoreductase
MNELTAVALVCTLKQSPADSSSDLIARQVLDELVGYGVKGEVLRVVDYDVHPGVTDNEGPRDQWPVLLEQIRSARIVLLATPTWLGHMSSVAQRVLERLDAELSRTDEAGRPALTGKVGVVAVVGNEDGAHKIVADVFQALNDLGFSIPAQGCTYWNDHAMGSTDYRDLDEVPEAVGKTNATVARNAAHLARLLAADNYPAP
>NZ_CP046172.1|WP_167479640.1|7368300_7368924_-|ANTAR-domain-containing-protein
MRTTGTFRFWFTDHRWEWSDEVMAIHGYSPGSVTPTTELMLKHKHPDDREQVADAITEAVTNGRPFSSSHRIIDTAGRVHQVLVLSSSMLDADGKVIGLEGYYVDLTDTVDERIQESLDETIADVVSARAVIEQAKGVLMRVYRINAEQAFRVLRWRSQETNVKLRALAAQLIAELTTMPPSTAEEQTAFDHMLLTLHERVDPHCDR
>NZ_CP046172.1|WP_167476819.1|7367066_7368260_-|AI-2E-family-transporter
MKRSTRAAADGGAEAGHDDVVGQPHTAAEGGPLLEAEAQAAQDSTPTHPLGRPGRPFDRRSPFMIGLTGAAGVATTYALIQAVLAAGQVLTLILVALFLAIGMEPAISWLVRPWFPRWAAVTLVCLVALGLFAGFLAILIPPLVEQGTALAHKAPDYVSHLAQRYPVIHDLDSRFHLEDKVQHWLSESSGLTGGVLDVGRALFSAVTSTVIVLVLTVYFMANFRRVRAVIYRLFPRARRPRAILIGDQIFAKVGGYILGNLLISLITGTLTFIWLLIFDVPYALVLAVLVAVLDLIPVVGSTAAGIVVALVALTVSVPVTIATVAFFIALRLVEDYLLVPPIIGRTVQVPAVVTVVAVLLGGALLGIVGALLAIPVAAALLLILRETVLPALDRGPA
>NZ_CP046172.1|WP_167476829.1|7376474_7376732_-|hypothetical-protein
MPVWLLVTGALLAGALPPGLALSARGPAEHRLVGLQLVSSVVVIVLVTASLGVGRPDYLIVPLVLVLLGFAGTLVFTRLAGESDD
>NZ_CP046172.1|WP_167476830.1|7376731_7377217_-|hypothetical-protein
MSRIASAVEAGAWWVVCVLIWLATVTVFTVQELLAACVFGVPCALVAQRARLAVRGSWRPPPELPRLLPALVAAVAADSAGALRLAVRTGREFGERTEIPLAETDSGARRSGREAAATMLFSATPGTIVVDSVEDGKKLVAHAFPLPETRLARSLRRAEAD
>NZ_CP046172.1|WP_167479642.1|7377213_7377780_-|hemerythrin-domain-containing-protein
MATKPEQDVVDLLTAQHEEIRTLLRRLRSGHEDKQELFSELVRLLAVHESAEEGVVHPVAKRAVFGAEEVVQPRLEEESEAKRALSELYDLGVDHPEFDARLAEFADAVDRHAAHEEREEFTLLRKQYSATQLERMAGSLRAAEAVAPTRPHPHAGESRMANLVVGPPLALFDRARDAVRDWRQSQGE
>NZ_CP046172.1|WP_167476831.1|7379735_7382606_+|FAD-binding-protein
MAAGSGREKFPMDALAQELTRRCAGEVRFDPGSRATYSTDASNYRAVPLGVVVPHTPDDAVAAIAVCREHDVPVLSRGGGTSLAGQCCNNGVVLDWTKYCHRLIAVDPQARSAIVEPGIALDDLNRQLAQYDLMVGPKPATHVSCTIGGMIGNNSCGSTAQAYGKIVDSVLRMEVLTYDGVRAWVGGPKADCDNEFAELRERLLTLGDRYADDIRAAYPDIPRRVSGYNLDSLLPERGCDLAKLLVGSESTLVTVLRAEIQLVPRPAAIAMAVLGFPDVYAAADAVPLVLEHRPAALEGLDHRLVELEHSRHLAEKAIQQLPAGKGWLMAQFDGADQKEADAKANAMIDELRERTGAEATMLDDPRREAEIWAAREAGLGATAFPQDGPETHEGWEDAAVPPERLGDYLRDFERLLKQFGYESSSLYGHFGHGCVHTRIPFDLRTSTGIARYREFVTAAAHLVAGYGGSLSGEHGDGQSRGELLPIMFGDTVVGAFRELKRILDPRNRMNPGKIVDAYPLDSRLRQGSDYRPWEPVTHFAFPDNSHRFSEAAGRCVGIGKCRGASGGVMCPSYRATREEEHSTRGRARLLFEMLNGEVITDGWRSTEVRDALDLCLSCKGCRSDCPVDVDMATYKAEFLSHHYRHRPRPLAHYSMGWIPLWARLATGMAPVANALAQGPTRRLLARAGGIDPRRQLPRFANRRFTRTFDGPTGSGARGKVLLWPDTFTNNFEPGIADAAVTVLRAAGFDIEIPARTVCCGLTWISTGQLPTAKRVLRRTLRQLAPQLRAGTPVVVLEPSCAAVFRADLPELLHGDEDAHRLAGQTHTLAELLAERAPEWKPPSRAGSALLQPHCHQHAILHHQHEQDLLSGIGVDVDVLDAGCCGLAGNFGFERGHYDVSVACAEDKLLPAIRAADPETMVLADGFSCRTQIRQLTPGARPRHTAEVLADAIGGAS
>NZ_CP046172.1|WP_167476832.1|7382602_7383709_+|mandelate-racemase
MNDDLRIGDAIDVAAYRFPTPQPEADGTLAWDQTTAVVVTIDAGGRRGTGWTYSGPATAAVIETELVPVLRELSPFDIGRCRNLMWRHCRNIGSTALVAHALSAVDIALWDLKARLLGVALTTLFGAVRPVTPVYGSGGFINLDDDQLGEQIDGWRAAGCRAVKIKIGADPGRDLARTALATKLIGPDTQLMVDANGAYSVGQARRVGAELDRLGVSWFEEPVTSDDPPGLAQVRAAVHCDIAAGEYAYGAYDAAALIGAVDCLQLDVTRCGGYTGFLACAAVAAAHGLDVSAHCAPALSAPVTAAIPNLRHIEWFIDHARLEPLLAEGVPRVAAGAIRPHADDPADPCGHGMRIAETAAPYRLPTHG
>NZ_CP046172.1|WP_167479643.1|7383724_7384288_-|superoxide-dismutase-family-protein
MNCKPYFLGAVAAVLLSPAIPANACDPVVSEGTFEPWQEGMVAVTYDTTLAPAGSRARIEIDNDGQTTTATFTVSGLLPNRVYGTHAHTKACGAKPADSGFHYQNVEDPNAKGKMSTDARYANPQNELWLDFTTDESGSATQVSNVDWVFRDGEPGSIVVHEKKTDTTDGKAGMAGARVACLSIPQP
>NZ_CP046172.1|WP_167476833.1|7385477_7387289_-|glycoside-hydrolase-family-15-protein
MIPDSASEPHVLREYALLADGQRGALVGPRGDISWLCLPGWDGDAVFATLLGGRGMYTVTPARRSVWGGYYETGSLIWHSHWVAGSALIECREALAFPGDPRRAVLLRRIIALHEDAEVDVLLRPAADFGTAKLRSAHRVQRGWRARLGPIRLRWTGAGSARLSGPPGDRCWTDHLRIAAGERHDLVLELADTELPDEPPDPEHLWAATESAWHREVPDLADAAAPRDAMQAYAVLRGMTGRSGGMVAAATTSLPERADQGENYDYRYVWIRDQCFAGQAAAAHGPHPLLDDAVQFTAARLLTDGPKLAPAYTMSGEIVPRARELDLPGYPGGFTVVGNQVRDQFQLDIFGEALLLFAAAGRHDRLTEEHRRAIGAAISAIAEHRNRPDAGIWEIEERRWAHSRLTCAAGLRAVAACTATGVDAGRCAALADSLVAEVSLDSVHPTGRWQRAPDTPGVDAALVLPMIRGAVPPHDPRSMATFRAIRRELTVDFHVYRYRHDDRPLESVEGAFLFCGFTMALAAAQLGQPVTALRFFERNRAACGTPGLFAEEFDVAQRQLRGNLPQAFVHALLLESAIRLAPLQEWPDPEPAVGRPIHGKEAI
>NZ_CP046172.1|WP_167476834.1|7387330_7388284_+|TIGR03557-family-F420-dependent-LLM-class-oxidoreductase
MVSFGYFLASEQFGPKELVDQARRAERAGFERLWISDHFHPWTDAQGHSPFVWGTIGALSQATALPVTTAVTCPTVRIHPAVIAQAAATAAVQLDGGFVLGVGSGEALNEHIFGDRWPAPAVRLEMLEEAVQLIRRMHRGGTVNHRGKHYEVQDARIYTLPDQPVPIYLSGFGPQATQLAARIGDGFCTVVPDADLVETFRAAGGGDKPVQAGTKLSWSRDEESGLDAAHQLWATDLLPGQLNQTLPRPRDFEDAMSLVDRETVRTNIASGPDPERHIRQLRQYLDAGVDELYVQQIGPDLDGFFTAWEKEIMPALQ
>NZ_CP046172.1|WP_167476835.1|7388289_7390428_-|catalase
MDGAAKDRGDGAQNEKQRQLDNYRVDRETGYLTTQQGVRVDSTDDAVKVGERGPTLLADFHAREKVTHFDHERIPERVVHARGAGAYGHFRPYNGWLAEFTSARFLIDPSVETPVFVRFSTVAGSRGSADTVRDVRGFATKFYTAQGNYDLVGNNFPVFFIQDGIKFPDFVHAVKPEPHNEIPQAQSAHDTLWDFVAQQPETLHAIMWLMSDRALPRSYRMMQGFGVHTFRLVNGEGRGTFVKFHWKPKLGVHSLLWDECQQIAGYDPDFNRRDLWDCIEAGQYPEWELGVQLVSDEREYAFDFDLLDPTKIIPEEQVPVQPVGSMVLDRNPDNFFAETEQVAFHTANLVPGIDFTDDPLLQLRNFSYLDTQLIRLGGPNFAQLPINRPIADVRNHQQDGYGQHAIPRGEAAYTKNTIGGGCPALADAGMFSHYAEPVTGAAIRQRASSFREYYRQPRMFWRSMSAPEADHIVAAFAFELGKVEREAIRLRIVEHLAFIDADLAVRVAGELGLPAPPPVPGTEDAVVSPALSQLAMNKVADTIATRKVAILAADGVDAAGVRRVRAWLTEHGAVTEILAPHGGTLRGDGDNGETLKVDRALPTMASVLYDGVIVAGGPQAADILASAGTAVHFVLGAFKHGKPVGGFGGGVTVLRLAGVVPDGSTDGDVGVANGVITTPVAGSGIPEDFIREFAAVLAQHRVWQRATAAVPA
>NZ_CP046172.1|WP_167476836.1|7390433_7391000_-|hemerythrin-domain-containing-protein
MTTEQREDVVTLLLAQHEQIKGLIERVETTHGEAKREAFEDLVRMLAIHETAEEEVVHPASRRASVSDSVVDSRLHEENEAKHVLSELYDMGVLHEGFDTKFRTFANSVVEHAEMEEKEEFGQLAQQTSADERKKLSDAVRVAEAVAPTRPHPHAGESAIANIIAGPPLALFDRVRDAVRDWRRKTEE

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Crispr_ID: NZ_CP046172_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046172_14

8274668-8274796

Orphan

Consensus_repeat	Method
CCGAGATTCTGAGCATCGTGCGCTCCTGACTGGAAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046172_14

>merge|NZ_CP046172|14|8274668-8274796|CRISPRCasFinder
CCGAGATTCTGAGCATCGTGCGCTCCTGACTGGAATCATGGAATCACATGCACGGGATTCGACAACCGAGGATGTAGACGGCTGTGCCCGATGCCGAGATTCTGAGCATCGTGCGCTCCTGACTGGAAT

>NZ_CP046172|14|14|8274668-8274796|CRISPRCasFinder
CCGAGATTCTGAGCATCGTGCGCTCCTGACTGGAAT	CATGGAATCACATGCACGGGATTCGACAACCGAGGATGTAGACGGCTGTGCCCGATG
CCGAGATTCTGAGCATCGTGCGCTCCTGACTGGAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046172.1\|WP_167479745.1\|8282547_8284083_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225827
NZ_CP046172.1\|WP_167477521.1\|8267138_8268377_-\|alkane-1-monooxygenase	unknown	unknown	gnl\|CDD\|239589
NZ_CP046172.1\|WP_167479743.1\|8270356_8271487_-\|2-phospho-L-lactate-transferase	unknown	unknown	gnl\|CDD\|237443
NZ_CP046172.1\|WP_041561325.1\|8271841_8272075_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NZ_CP046172.1\|WP_167477523.1\|8269013_8270360_-\|coenzyme-F420-0:L-glutamate-ligase	unknown	unknown	gnl\|CDD\|183957
NZ_CP046172.1\|WP_167477518.1\|8266114_8266738_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|375982
NZ_CP046172.1\|WP_167477533.1\|8281178_8281781_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_CP046172.1\|WP_167479744.1\|8272727_8273114_+\|DUF3499-domain-containing-protein	unknown	unknown	gnl\|CDD\|378788
NZ_CP046172.1\|WP_167477524.1\|8272145_8272625_+\|metallopeptidase-family-protein	unknown	unknown	gnl\|CDD\|240574
NZ_CP046172.1\|WP_167477527.1\|8276082_8277303_+\|mannose-6-phosphate-isomerase,-class-I	unknown	unknown	gnl\|CDD\|380414
NZ_CP046172.1\|WP_167477530.1\|8279746_8280325_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379115
NZ_CP046172.1\|WP_167477528.1\|8277373_8278288_+\|cation-diffusion-facilitator-family-transporter	unknown	unknown	gnl\|CDD\|223131
NZ_CP046172.1\|WP_167477522.1\|8268495_8269017_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|239646
NZ_CP046172.1\|WP_167477520.1\|8266968_8267142_-\|rubredoxin	unknown	unknown	gnl\|CDD\|366011
NZ_CP046172.1\|WP_167477532.1\|8280959_8281175_+\|DUF4287-domain-containing-protein	unknown	unknown	gnl\|CDD\|379478
NZ_CP046172.1\|WP_167477519.1\|8266789_8266972_-\|rubredoxin	unknown	unknown	gnl\|CDD\|366011
NZ_CP046172.1\|WP_167477534.1\|8281849_8282551_-\|response-regulator	unknown	unknown	gnl\|CDD\|226931
NZ_CP046172.1\|WP_167477531.1\|8280427_8280823_+\|DUF4267-domain-containing-protein	unknown	unknown	gnl\|CDD\|372907
NZ_CP046172.1\|WP_167477526.1\|8274880_8276083_+\|tobH-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167477529.1\|8278272_8279736_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224154

Protein	Function_ID	Function_description	E-value
NZ_CP046172.1\|WP_167479745.1\|8282547_8284083_-\|sensor-histidine-kinase	gnl\|CDD\|225827	COG3290, CitA, Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms].	3.91219e-115
NZ_CP046172.1\|WP_167477521.1\|8267138_8268377_-\|alkane-1-monooxygenase	gnl\|CDD\|239589	cd03512, Alkane-hydroxylase, Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes in Pseudomonas oleovorans encode conversion of alkanes to acyl CoA. The alkane omega-hydroxylase (AlkB) system is responsible for the initial oxidation of inactivated alkanes. It is a three-component system comprising a soluble NADH-rubredoxin reductase (AlkT), a soluble rubredoxin (AlkG), and the integral membrane oxygenase (AlkB). AlkB utilizes the oxygen rebound mechanism to hydroxylate alkanes. This mechanism involves homolytic cleavage of the C-H bond by an electrophilic metal-oxo intermediate to generate a substrate-based radical. As with other members of this superfamily, this domain family has extensive hydrophobic regions that would be capable of spanning the membrane bilayer at least twice. The active site structure of AlkB is not known, however, spectroscopic and genetic evidence points to a nitrogen-rich coordination environment located in the cytoplasm with as many as eight histidines coordinating the two iron ions and a carboxylate residue bridging the two metals. Like all other members of this superfamily, there are eight conserved histidines seen in the histidine cluster motifs: HXXXH, HXXXHH, and HXXHH. These histidine residues are reported to be catalytically essential and proposed to be the ligands for the iron atoms contained within the homolog, stearoyl CoA desaturase. Also included in this CD are terminal alkane hydroxylases (AlkM), xylene monooxygenase hydroxylases (XylM), p-cymene monooxygenase hydroxylases (CymAa), and other related proteins.	8.94168e-147
NZ_CP046172.1\|WP_167479743.1\|8270356_8271487_-\|2-phospho-L-lactate-transferase	gnl\|CDD\|237443	PRK13606, PRK13606, LPPG:FO 2-phospho-L-lactate transferase; Provisional.	1.39855e-174
NZ_CP046172.1\|WP_041561325.1\|8271841_8272075_+\|transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	2.15093e-28
NZ_CP046172.1\|WP_167477523.1\|8269013_8270360_-\|coenzyme-F420-0:L-glutamate-ligase	gnl\|CDD\|183957	PRK13294, PRK13294, F420-0--gamma-glutamyl ligase; Provisional.	0
NZ_CP046172.1\|WP_167477518.1\|8266114_8266738_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|375982	pfam18556, TetR_C_35, Bacterial Tetracyclin repressor, C-terminal domain. This is the C-terminal tetracyclin repressor domain found in bacteria. Family members include TetR family transcriptional regulators Rv3249c and Rv1816 found in Mycobacterium tuberculosis. Palmitic acid (a fatty acid) and isopropyl laurate (a fatty acid ester), were identified as binding ligands to Rv3249c and Rv1816 respectively. Similar to other TetR family regulators, these proteins are alpha-helical dimeric proteins consisting of a smaller N-terminal DNA-binding domain and a larger C-terminal regulatory domain.	7.15476e-33
NZ_CP046172.1\|WP_167477533.1\|8281178_8281781_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	8.51948e-23
NZ_CP046172.1\|WP_167479744.1\|8272727_8273114_+\|DUF3499-domain-containing-protein	gnl\|CDD\|378788	pfam12005, DUF3499, Protein of unknown function (DUF3499). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 125 to 163 amino acids in length.	1.74508e-62
NZ_CP046172.1\|WP_167477524.1\|8272145_8272625_+\|metallopeptidase-family-protein	gnl\|CDD\|240574	cd12954, MMP_TTHA0227_like_1, Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria. The subfamily includes some uncharacterized bacterial proteins which show high sequence similarity with Thermus thermophilus hypothetical protein TTHA0227. However, they do not contain the conserved HExxH (x could be any amino acid) motif. They may not have any zinc metallo-peptidase activity.	1.16668e-25
NZ_CP046172.1\|WP_167477527.1\|8276082_8277303_+\|mannose-6-phosphate-isomerase,-class-I	gnl\|CDD\|380414	cd07011, cupin_PMI_type_I_N, type I phosphomannose isomerase in eukaryotes and bacteria, N-terminal cupin domain. This subfamily contains type I phosphomannose isomerase (PMI; E.C. 5.3.1.8; also known as mannose-6-phosphate isomerase) found in eukaryotes and some bacteria such as Salmonella enterica. PMI catalyzes the reversible isomerization of fructose-6-phosphate (F6P) and mannose-6-phosphate (M6P), the first committed step in the synthesis of mannosylated glycoproteins. The active site, located within the N-terminal jelly roll-like beta-barrel cupin fold, contains a single essential zinc atom and forms a deep, open cavity large enough to contain M6P or F6P. PMI type I also has a C-terminal beta-barrel fold which has diverged considerably from the N-terminal domain and is not included here. This subfamily contains an alpha helical domain that is found in eukaryotic and some prokaryotic PMIs but is not present in their archaeal counterparts. F6P is a substrate for glycolysis and gluconeogenesis, while M6P is a substrate for production of activated mannose donor guanosine 5'-diphosphate D-mannose, an important precursor of mannosylated biomolecules such as glycoproteins, bacterial exopolysaccharides and fungal cell wall components. PMI is also essential for survival, virulence and possibly pathogenicity of some bacteria and protozoan parasites, as well as for cell wall integrity of certain yeasts. Thus, PMI is a potential target against fungal infections causing serious illness or death.	2.21658e-100
NZ_CP046172.1\|WP_167477530.1\|8279746_8280325_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379115	pfam13305, WHG, WHG domain. This presumed domain is around 80 amino acids in length. It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. The domain is named WHG after three conserved residues near the C-terminus of the domain.	3.97911e-11
NZ_CP046172.1\|WP_167477528.1\|8277373_8278288_+\|cation-diffusion-facilitator-family-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	8.70452e-39
NZ_CP046172.1\|WP_167477522.1\|8268495_8269017_-\|NUDIX-domain-containing-protein	gnl\|CDD\|239646	cd03674, Nudix_Hydrolase_1, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, U=I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	7.56003e-28
NZ_CP046172.1\|WP_167477520.1\|8266968_8267142_-\|rubredoxin	gnl\|CDD\|366011	pfam00301, Rubredoxin, Rubredoxin.	1.99265e-19
NZ_CP046172.1\|WP_167477532.1\|8280959_8281175_+\|DUF4287-domain-containing-protein	gnl\|CDD\|379478	pfam14117, DUF4287, Domain of unknown function (DUF4287). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 70 and 180 amino acids in length.	1.49488e-21
NZ_CP046172.1\|WP_167477519.1\|8266789_8266972_-\|rubredoxin	gnl\|CDD\|366011	pfam00301, Rubredoxin, Rubredoxin.	8.18193e-22
NZ_CP046172.1\|WP_167477534.1\|8281849_8282551_-\|response-regulator	gnl\|CDD\|226931	COG4565, CitB, Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms].	1.2507e-55
NZ_CP046172.1\|WP_167477531.1\|8280427_8280823_+\|DUF4267-domain-containing-protein	gnl\|CDD\|372907	pfam14087, DUF4267, Domain of unknown function (DUF4267). This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 126 and 142 amino acids in length.	1.75646e-21
NZ_CP046172.1\|WP_167477529.1\|8278272_8279736_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	6.90306e-82

>NZ_CP046172.1|WP_167479744.1|8272727_8273114_+|DUF3499-domain-containing-protein
MRRCCRPGCKNPAVATLTYVYSDSTAVVGPLATVAEPHSWDLCETHGSRITAPKGWELVRHEGGFSSSTPDDDDLTALAEAVREAGLRRRAPEPERQQRGYTGYPPPAQRAQRTGRRGHLRVLPDPPS
>NZ_CP046172.1|WP_167477524.1|8272145_8272625_+|metallopeptidase-family-protein
MARSRKRRPPTARSVIRRGRGVRGPMLPPTVPAWRTRGQKFDRLVLEAFAPLDTRWHDRLTKLDIAVDDVPKIRPLHPDSVTWPDEVVADGPVPLSRLIPAGVDRHGAATRARVVLFRKPLELRASDPDDLVDLLREVLVQQVATYLGVDPDVIDPEAE
>NZ_CP046172.1|WP_041561325.1|8271841_8272075_+|transcriptional-regulator
MFESIEEQWQERALCAQTDPEAFFPEKGGSTREAKRICMGCEVRDECLEYALAHDERFGIWGGLSERERRRLKRGIS
>NZ_CP046172.1|WP_167479743.1|8270356_8271487_-|2-phospho-L-lactate-transferase
MVKPPTLFRYYPRPHSSSILKCHSANDQQIWGESRFGGYRIGCADVSGQHAGTAPASGPRIAVLVGGVGGARFLQGVRELLPQADISAIVNVGDDVWMHGLRICPDLDTCMYTLGGGIDTERGWGRVGETWHAKEELANYRAQPDWFGLGDRDIATHLIRSEMLRAGYPLSAVTEALCKRWQPGVKLVPATDDRCETHVVVTDPENPGERKAIHFQEWWVRYRAGIETHGFATIGAEQAKPAPNVTEIISAADAVLLAPSNPVVSIGSILAVPGIRGALRTTEAKVVGLSPVIDGKPLRGMADECLSVIGVETSAEAVGRYYGARSETGILDGWLVHTTDSAEVPGVEVRSVPLLMTDPQTTAEMAREALELAGVK
>NZ_CP046172.1|WP_167477523.1|8269013_8270360_-|coenzyme-F420-0:L-glutamate-ligase
MTALPDHAASELRILPVVGLPEFRPGDDLVAQLADKAPWLADGDILVVTSKIVAKAEGRIVAAPLDPEERDAARRELVAREAVRVLARKGRTLITENRLGIVQAASGVDGSNVEQGELVLLPTDPDASAKALREGLAARLGVNVAVVITDTMGRAWRSGQIDAAIGAAGLRVLHDYNGAVDGQGNELHVTQVAIADELAAAADLVKGKLGGVPVAVVRGLPVTDDGSTAADLLRTGTDDLFWLGTAEAIDKGRREAVLLRRSIRQFADTPVDPERIRAAVAVALTAPAPHHTRPVRFVWVREPGLRKQLLEAMADKWRADLGGDGRTPDSIERRVARGRILFDAPEMIIPFCVPDGAHDYPDERRRAAERTMFTVAVGAAVQGLLVALATEGIGSCWIGSTIFAPEITRAVLGLEADWNPLGAIAIGYPPEELAPRPVPAPDFGLVEL
>NZ_CP046172.1|WP_167477522.1|8268495_8269017_-|NUDIX-domain-containing-protein
MSAESLHKSAVVLLETWQPPTDSDRALTVALLAFLDSAPRGCLREYAPGHITASALVFSHDEREVLLTLHPRVGLWIQLGGHCEEFDETVSDAALREAIEESGIPGLELDPGLYGVQAHSITCSLGVPTRHLDLLFRIRAPKGAEPVHSAESTDLRWWPVDALPKDAEVPLRG
>NZ_CP046172.1|WP_167477521.1|8267138_8268377_-|alkane-1-monooxygenase
MSTDTDRSGARITAPAWRDRKRYLWLWGLFAPTGLFTIGLPLVWAFNEIGWHRAAQVPFWLGPILVYLLIPLADICFGPDGDNPPDEVMEYLENDKYYRYLTYLYLPFQYATLIMACYLIAAPNLGWLGIDGGLHLVDKIGLAVTVGMIGGIGINTAHELGHKKVDLERWLSRIALAQSFYGHFYIEHNRGHHVRVATPDDPASSRVGETFWAFWPRTVFGSLRSAWRLERARLARLGKRPLSPRNEVLSAWAMSAVLWAALVAVFGIGVLPYLALQAVVGFSLLEAVNYLEHYGLVRQRTASGRYERPAPVHSWNSDHIVTNIFLYHLQRHSDHHAYPTRRYQTLRSWDGAPNLPSGYASMILLAYFPPLWRRVMDKRVLAHYGGDITRANIDPAKRDKVIARYGHAGVRS
>NZ_CP046172.1|WP_167477520.1|8266968_8267142_-|rubredoxin
MSAYRCPVCGYVYDEAKGAPREGFPAGTAWAAVPDDWCCPDCGVREKVDFEPVGIVK
>NZ_CP046172.1|WP_167477519.1|8266789_8266972_-|rubredoxin
MTEYKLYQCVQCGFEYDEAKGWPEDGIAPGTRWEDIPDNWSCPDCGAAKSDFYMVEIERS
>NZ_CP046172.1|WP_167477518.1|8266114_8266738_-|TetR/AcrR-family-transcriptional-regulator
MPRTGTRIPYQEAARELLRTSVLDAMRELLTERDWSKITLGDVAARAGVSRQTLYNEFGSRAGLAQAYALRLADDLVDHVDSAIANNVGDARAAFKEGLAGFFLDAAADPLVRSLLAGEVKLDLLRLITLDAGPLLDRATERLSVAFQQSWVAATAEESDVIAHALVRIALSYIPTPPAPGRNAPAELSALLSPYVEAILAAREASR
>NZ_CP046172.1|WP_167477526.1|8274880_8276083_+|tobH-protein
MIAGTPVLDLDDAASLQAADAGGALRSAASGGAQVRATAAAVGEDALARLKDLRPRSVVLVSGSGRATRAAGLLVAALGDRVGLPIVPVAALPPWVGPLDVVLVSGDDAGDPRLIDAVDRALRRGAEVVVAAPHEGPLRAAAAGRAALLEPRIQVLDHNRLLRFLAAGIAVLAAVDPGRAGAAVPDLTELADVLDAEALRDGPQNEVFHNPAKTLAARMQQRGIVLAGDSPAATQLAEHGAEVLLAAAGKVATAVNLAEAVAANPQMTEAAGQSAPGFDPLFHDEQLDGPAPVERLRVFVLSTDPDQVAARRRLAVFGGGPGLVDADLVSADVDLLHTEFTDPGAPAPTEEPRPATGRGSELEQLAVLALRLEMAAAYLRLIGSRGAATTGSGDYDGGRY
>NZ_CP046172.1|WP_167477527.1|8276082_8277303_+|mannose-6-phosphate-isomerase,-class-I
MHELVGALRNYAWGSRTALAQLCGRPVPSAHPEAELWFGAHPADPALVRIGGRKRSLLELVSDDPERELGSAAPEFGGKLPFLLKILAAEEPLSLQAHPSLAQALEGYQRENRARVPLDSPLRNYRDENHKPELVVALERFEALAGFREPRRTVDLLRALDVPGLAQYADLLAEAPDSSGLRTLFTTWITLPQPALATLLPAVLDGCVRYLSGKGRRAFGAEARTALELAEAYPGDAGVLAALLLNRVTLEPGQGLYLAAGNLHAYLRGLGVEIMANSDNVLRGGLTPKHVDVPELLRVLDFEPIDVPFVLPEPAGDGSVRYRTPAPEFELRRFDLAAGSGQVPLTAAGPGIVLCTSGAVRLLQNGAELLVERGGAAWISAADSDIRAQAVDGAAQLFCACVGAGN
>NZ_CP046172.1|WP_167477528.1|8277373_8278288_+|cation-diffusion-facilitator-family-transporter
MSAGGGKKAIIAALSANAGIAAAKFVGAALTGSGSMLAEAVHSVADTANQGLLLLGQRRAAREADELHPFGYGRNRYFYSFIVALVLFTLGSIYAIYEGVHKVQHPEELSNPLVAVVILVIAIALEGFSFTTAMRESAPLKGSASWWRFIRNSRSPELPVVLLEDTGALIGLLFAFAGVGLTMLTGDPVWDGIGTLAIGALLGVIALVLIVEMQSLLIGEGATPDEDRAIRANLVDGTRIDRVIHLKTQYLGPEEILVAAKVSIVPGLDIADIAAAIDDAEARVRAAVPAARVMYLEPDLYRTR
>NZ_CP046172.1|WP_167477529.1|8278272_8279736_-|NAD(P)/FAD-dependent-oxidoreductase
MPDVVVVGSGPNGLAAAVILAKAGLSVEVFEAQPTAGGGSRTAELTLPGYRHDVCAGAHPMALASPVFRAFDLTAHGVELLAPEVSYAHPLDDGRAGLAWRDLDRTVDGLGPDGPAWRSLFGPLVRHWTEVVDVAMGDLRHIPRAIPSAIRFGLRLLEQGSPLWNTRFRDDAAPAMLSGIATHAITPPRALPAVGAGLLLGTLAHVGGWVLPRGGSQAIPDALIGELERLGGKVHLGHRVDSLDEFGTARAVVLDTAPAELLRLAGDRLPQRYAKQLNRFRYGGAACKVDFALSGPVPWRAAGCELAGTLHLVGTRAEAMAAEKTVAAGQHAERPYVLAVQPGVVDPTRAPAGGHTLYSYTHVPNGSTRDVSEAVIAQIERFAPGFRDLIVAKHVYTAAELPAHNANYIGGDISAGAMSLRQVPFRPAARWNPYGTPLPGVYLCSAATPPGPGVHGMNGLHATRHVLRERFGIRTDPLDLLAGQRVR
>NZ_CP046172.1|WP_167477530.1|8279746_8280325_-|TetR/AcrR-family-transcriptional-regulator
MSTQTRKERERAERHQRIIDAARELAEADGWEAVTVRKLAERIEYSQPVLYSHFAGKSAIVAAVAVQGCVDLTRELRKAKAGTETHAATLTAMARGYLDFAAANPALYDAMFVLNVDLVFGLDAPQPLRDAFAEIENPFRPYITDPDELGARAETAWSTLHGLATLERSGRLRPELRDRRLEIVVGEWLAAG
>NZ_CP046172.1|WP_167477531.1|8280427_8280823_+|DUF4267-domain-containing-protein
MTTSRIATGLAIVGAAFILYIGISYLVAPESTASSFGLPAWPTGDADGFLNVKGVRDTVTGILVIALLVAKQRFALGVTLLAVALIPVGDMLTVLARHGSTAAAFGIHGLTAALVALTGVLLVRERRSVTA
>NZ_CP046172.1|WP_167477532.1|8280959_8281175_+|DUF4287-domain-containing-protein
MANQPKGPASYFPAIEAKYGKTIDEWKSLIRESGLTAHKELVEWLKNTHGFGHGHANAIVQHHLHPEKWAA
>NZ_CP046172.1|WP_167477533.1|8281178_8281781_-|GNAT-family-N-acetyltransferase
MSEWSEHTELVGTHVRLTPLGQEHAKGLLEAGRDPGIWTWLSRRAPVDLADAEQMVAETLADPERRAFAQIDLVSGQVAGTTSYYEISERHRSISIGYTWLGPAWQRSALNTEAKLLLLRHAFETLGAQRVSWHTDIRNLRSQRAIERLGALREGVLRAHRIRPDGTSRDTVLYSMLAPEWPSARDRLTQRLNTFRAEAA
>NZ_CP046172.1|WP_167477534.1|8281849_8282551_-|response-regulator
MIRVLIVEDEPLIAEAHRAYVERIPGFVPVAVAHTGREAMRATADAAAEGAPIDLVLMDIGLPDASGLDVAAAMTGLAPRPDVIAITSARDLALVRTAVSYGVVLYLLKPFTFAAFRDKLERYRDFRAALPAGEAAVSQQDIDRALGALRTPDQRATAPKGVAPQTLDEISRAVRGAPDGITAADTATTVGVSRITAWRYLEKLAEDGLVTRRSDYGRAGRPKTRYVWRPSER
>NZ_CP046172.1|WP_167479745.1|8282547_8284083_-|sensor-histidine-kinase
MSLAGQTFVLQLIVLALVIGAGAGLAVLEERSSRDDATRQQVIAVAVSVAQAPSTIAAVQSPDPTAQLQPVTERIRKQTGMDFIVVMAPDRTRYTHTVPERIGHAFTGNIDRALKGETFTEIFPGTLGPSIRAVTPVYAGDRIVALVSAGVTRAKIGDQVGAQLPLILGVTAIGLIVATIGSLLLSRRLRRLTHGLAPDELRTMYEHHDAVLHSIREGLLVFGAAGDRADVVNDEARRLLDLPPGEIRRDDLPVSFQRLGPGLVRDEMHVTDSRILLVNQDPVTWEGRPLGTVLTIRDHTELRGVLGELDSVRSFAESLRAQAHESANRLHTVVTMVELGRYREAVEFATAELQLSQALIDRLLAAVGDPALAALLLGKVNQAAERGIELTVTQDTALDSTAPLTAHEAVTLVGNLIDNALDAATDNAAGWVEVTVRHDDSVLYVRVADSGPGMSPETFARAAERGYSTKADHQGLGLALVHRVVSRYGGVIETVVRPESAVTARIPRGDR

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Crispr_ID: NZ_CP046172_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046172_15

8376705-8376828

Orphan

Consensus_repeat	Method
GCCGACGTAATCCCCGACGGCGCAACGGGATACCCATC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046172_15

>merge|NZ_CP046172|15|8376705-8376828|CRISPRCasFinder
GCCGACGTAATCCCCGACGGCGCAACGGGATACCCATCAATCACCGTCCAGGTCTCCTGACCAGCCCTGTCGGCACCGCCGCACGCGCCGACGTAATCCCCGACGGCGCAACGGGATATCCATC

>NZ_CP046172|15|15|8376705-8376828|CRISPRCasFinder
GCCGACGTAATCCCCGACGGCGCAACGGGATACCCATC	AATCACCGTCCAGGTCTCCTGACCAGCCCTGTCGGCACCGCCGCACGC
GCCGACGTAATCCCCGACGGCGCAACGGGATATCCATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046172.1\|WP_167477603.1\|8378505_8379144_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367559
NZ_CP046172.1\|WP_167479757.1\|8379304_8380180_-\|transporter	unknown	unknown	gnl\|CDD\|270324
NZ_CP046172.1\|WP_167477596.1\|8366582_8368373_+\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|223953
NZ_CP046172.1\|WP_167477608.1\|8385013_8386330_-\|DUF1800-domain-containing-protein	unknown	unknown	gnl\|CDD\|378055
NZ_CP046172.1\|WP_167477597.1\|8368427_8369168_-\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_CP046172.1\|WP_167477602.1\|8376928_8378413_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|129794
NZ_CP046172.1\|WP_167477600.1\|8370904_8374102_+\|phosphoenolpyruvate--protein-phosphotransferase	unknown	unknown	gnl\|CDD\|224006
NZ_CP046172.1\|WP_167477594.1\|8364753_8365587_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187598
NZ_CP046172.1\|WP_167477598.1\|8369283_8370285_+\|dihydroxyacetone-kinase-subunit-DhaK	unknown	unknown	gnl\|CDD\|237724
NZ_CP046172.1\|WP_167477607.1\|8383808_8384996_-\|DUF1501-domain-containing-protein	unknown	unknown	gnl\|CDD\|226587
NZ_CP046172.1\|WP_167477595.1\|8365605_8366529_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|369561
NZ_CP046172.1\|WP_167477593.1\|8363218_8364757_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224983
NZ_CP046172.1\|WP_167477599.1\|8370287_8370908_+\|dihydroxyacetone-kinase-subunit-L	unknown	unknown	gnl\|CDD\|274099
NZ_CP046172.1\|WP_167479756.1\|8374219_8374876_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|381691
NZ_CP046172.1\|WP_167479759.1\|8386447_8387656_-\|NADP-dependent-malic-enzyme	unknown	unknown	gnl\|CDD\|223358
NZ_CP046172.1\|WP_167477606.1\|8383108_8383795_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224095
NZ_CP046172.1\|WP_167477592.1\|8362516_8363149_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP046172.1\|WP_167477605.1\|8382443_8383112_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224095
NZ_CP046172.1\|WP_167477604.1\|8381296_8382439_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224050
NZ_CP046172.1\|WP_167479758.1\|8380399_8381284_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270324

Protein	Function_ID	Function_description	E-value
NZ_CP046172.1\|WP_167477603.1\|8378505_8379144_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|367559	pfam03551, PadR, Transcriptional regulator PadR-like family. Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.	4.36584e-09
NZ_CP046172.1\|WP_167479757.1\|8379304_8380180_-\|transporter	gnl\|CDD\|270324	cd13606, PBP2_ProX_like, Bacterial substrate-binding protein ProX of ABC-type osmoregulated transporter and its related proteins; the type 2 periplasmic-binding protein fold. This group includes periplasmic substrate-binding component of ABC transport systems from gram-negative and -positive bacteria that are involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	4.19559e-51
NZ_CP046172.1\|WP_167477596.1\|8366582_8368373_+\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|223953	COG1022, FAA1, Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism].	0
NZ_CP046172.1\|WP_167477608.1\|8385013_8386330_-\|DUF1800-domain-containing-protein	gnl\|CDD\|378055	pfam08811, DUF1800, Protein of unknown function (DUF1800). This is a family of large bacterial proteins of unknown function.	2.29917e-100
NZ_CP046172.1\|WP_167477597.1\|8368427_8369168_-\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	4.79245e-49
NZ_CP046172.1\|WP_167477602.1\|8376928_8378413_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.51831e-84
NZ_CP046172.1\|WP_167477600.1\|8370904_8374102_+\|phosphoenolpyruvate--protein-phosphotransferase	gnl\|CDD\|224006	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism].	0
NZ_CP046172.1\|WP_167477594.1\|8364753_8365587_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187598	cd05339, 17beta-HSDXI-like_SDR_c, human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs. 17-beta-hydroxysteroid dehydrogenases (17betaHSD) are a group of isozymes that catalyze activation and inactivation of estrogen and androgens. 17betaHSD type XI, a classical SDR, preferentially converts 3alpha-adiol to androsterone but not numerous other tested steroids. This subgroup of classical SDRs also includes members identified as retinol dehydrogenases, which convert retinol to retinal, a property that overlaps with 17betaHSD activity. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	2.90889e-56
NZ_CP046172.1\|WP_167477598.1\|8369283_8370285_+\|dihydroxyacetone-kinase-subunit-DhaK	gnl\|CDD\|237724	PRK14481, PRK14481, dihydroxyacetone kinase subunit DhaK; Provisional.	0
NZ_CP046172.1\|WP_167477607.1\|8383808_8384996_-\|DUF1501-domain-containing-protein	gnl\|CDD\|226587	COG4102, COG4102, Uncharacterized protein conserved in bacteria [Function unknown].	6.22788e-55
NZ_CP046172.1\|WP_167477595.1\|8365605_8366529_+\|alpha/beta-hydrolase	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.55605e-57
NZ_CP046172.1\|WP_167477593.1\|8363218_8364757_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224983	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism].	6.91736e-105
NZ_CP046172.1\|WP_167477599.1\|8370287_8370908_+\|dihydroxyacetone-kinase-subunit-L	gnl\|CDD\|274099	TIGR02365, dha_L_ycgS, dihydroxyacetone kinase, phosphoprotein-dependent, L subunit. Two types of dihydroxyacetone kinase (glycerone kinase) are described. In yeast and a few bacteria, e.g. Citrobacter freundii, the enzyme is a single chain that uses ATP as phosphoryl donor and is designated EC 2.7.1.29. By contract, E. coli and many other bacterial species have a multisubunit form (EC 2.7.1.-) with a phosphoprotein donor related to PTS transport proteins. This family represents the subunit homologous to the E. coli YcgS subunit.	9.80611e-74
NZ_CP046172.1\|WP_167479756.1\|8374219_8374876_+\|transcriptional-regulator	gnl\|CDD\|381691	cd16099, TenA_PqqC-like, TenA-like proteins including TenA_C and TenA_E proteins, as well as pyrroloquinoline quinone (PQQ) synthesis protein C. TenA proteins participate in thiamin metabolism and can be classified into two classes: TenA_C which has an active site Cys, and TenA_E which does not; TenA_E proteins often have a pair of structurally conserved Glu residues in the active site. TenA_C proteins (EC 3.5.99.2) catalyze the hydrolysis of the thiamin breakdown product amino-HMP (4-amino-5-amino-methyl-2-methylpyrimidine) to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) in a thiamin salvage pathway; the role of TenA_E proteins is less clear. Arabidopsis thaliana TenA_E hydrolyzes amino-HMP to AMP, and the N-formyl derivative of amino-HMP to amino-HMP, but does not hydrolyze thiamin. Bacillus subtilis TenA_C can hydrolyze amino-HMP to AMP and can catalyze the hydrolysis of thiamin. Saccharomyces cerevisiae THI20 includes a C-terminal tetrameric TenA-like domain fused to an N-terminal ThiD domain, and participates in thiamin biosynthesis, degradation and salvage; the TenA-like domain catalyzes the production of HMP from thiamin degradation products (salvage). Bacillus halodurans TenA_C participates in a salvage pathway where the thiamine degradation product 2-methyl-4-formylamino-5-aminomethylpyrimidine (formylamino-HMP) is hydrolyzed first to amino-HMP by the YlmB protein, and the amino-HMP is then hydrolyzed by TenA to produce HMP. Helicobacter pylori TenA_C is also thought to catalyze a salvage reaction but the pyrimidine substrate has not yet been identified. It has also been suggested that TenA proteins act as transcriptional regulators based on changes in gene-expression patterns when TenA is overexpressed in Bacillus subtilis, however this effect may be indirect; Pyrococcus furiosus TenA_E lacks appropriate surface charges for DNA interactions. This family also includes bacterial coenzyme pyrroloquinoline quinone (PQQ) synthesis protein C (PQQC), an oxidase involved in the final step of PQQ biosynthesis, and CADD, a Chlamydia protein that interacts with death receptors.	0.0013769
NZ_CP046172.1\|WP_167479759.1\|8386447_8387656_-\|NADP-dependent-malic-enzyme	gnl\|CDD\|223358	COG0281, SfcA, Malic enzyme [Energy production and conversion].	6.02324e-164
NZ_CP046172.1\|WP_167477606.1\|8383108_8383795_+\|ABC-transporter-permease	gnl\|CDD\|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	3.16642e-57
NZ_CP046172.1\|WP_167477592.1\|8362516_8363149_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	9.30557e-09
NZ_CP046172.1\|WP_167477605.1\|8382443_8383112_+\|ABC-transporter-permease	gnl\|CDD\|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	6.45896e-43
NZ_CP046172.1\|WP_167477604.1\|8381296_8382439_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224050	COG1125, OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism].	3.2842e-128
NZ_CP046172.1\|WP_167479758.1\|8380399_8381284_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270324	cd13606, PBP2_ProX_like, Bacterial substrate-binding protein ProX of ABC-type osmoregulated transporter and its related proteins; the type 2 periplasmic-binding protein fold. This group includes periplasmic substrate-binding component of ABC transport systems from gram-negative and -positive bacteria that are involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.56463e-123

>NZ_CP046172.1|WP_167479756.1|8374219_8374876_+|transcriptional-regulator
MTGSARELLDEIQTELAPQDEDNRLVPLIVAGKAPRAVFAAIATEEHRITGSDWRSFHALAARADEPNARAFFGALAPGEQQALGMIDELLAAAGPDPGRQRPRAGCQAYPAFMAWLALNAESAAAAAGIFANFKAFGRYCKDVAAGMREHYGFDDKACGFFDFFAADVPEIEQQALAAIQAGLDSGRLIRADAHLYARLFQSYELMFWNTLADEFGG
>NZ_CP046172.1|WP_167477600.1|8370904_8374102_+|phosphoenolpyruvate--protein-phosphotransferase
MIGIVVVSHSRPLARAAVALATEMQGERPVRVEIAAGLDEETLGTDAVAVAEAIAAADSGDGVLLLMDLGSAVLSAELAIDLLESPHEVKLCAAPIVEGLVAAVVTAGSGASLDEVAAEAENALLGKRSQLGMDGQAQPATDATPEHDTHPRPSEKASGQPQPAADATPEHDTHPRPSEKASGQPRPAADITPGQDTHLRPGDEPGEHHPIVTNSGAQHDNSIQRTTIVVRNEHGLHARPAARLVAALRGIDTDVRLRNLTTGAGPVSGRSLTRIAALGVLTGHQIEVSATGTDAATAIDRIRALADRWFDEEPTEAERNASHTRSTESARPATESPDAASGSLHAADSAAGPSDAAPTDYEPGQSAAPVGTSSAFNNASESIRTTPEPTDQSGSPTKRSDATPNGREPRLSTASVSAPASSDASESIRTTPESADHPGSSAEQPGATPTDSESARSAASRGAPRSTSPATGSNRVAPEVLAGTQGGIESVGGAIESTDAGGSRPPGTEPEGRRTGPYPASAGIGIGPVWHLATTEFTLPEHPAGAPVDEQRALDDAIGRVREQLTADIARSDGGRSPEADIFEAHLILLDDEDLTDEVRRRIADGAPAATAFAAVFDGAAAELARLPDEYQRARAADVRAVRDQVLVVLLGYSSEFVTRPGILVAADLTPGQLAALDRSLLDGIVLAQGSPTAHSAILARSKGIPAVVGAGAEVLRIPEDTVVALDGGTGRLVVAPKPSVLAEFETRAREQDEQRRAAEAAAQERAVTENGTEIHVAANVGSVADAVDAVRAGADLAGLVRTEFLFLGREHAPTVAEQTEVYRELAKVFDGRRIILRTLDVGGDKPLPYIDQRPEANPFLGLRGIRLALAHPDLLRDQLRAVAAVAADHPVSVMFPMVTGLDELQAARKILNEVAPQDLSLEIGIMIEVPAAAVKAAVLAEYVDFFSIGTNDLTQYAMAVDRGNDTIAALADPLDPGVLRLIDLVCRGAGDTRVAVCGEIAADPAAVPLLLGLGVTELSVAPPAVAMVKAQVRTLDTTRCRALAVEALGCESAAQVRGLVRRQA
>NZ_CP046172.1|WP_167477599.1|8370287_8370908_+|dihydroxyacetone-kinase-subunit-L
MTVIDPVAWVREFAALIDENADTLTELDAAIGDADHGSNMRRGTAAVVAAFAEAEPDSAAAALKQTSMVLIRSVGGASGPLYGTFFLRFAAAVGQDGVDASTFAKAFRAGLDGVVARGKAEAGDKTMFDALAPAADAFDEKLAAGGEFADALDAALAAAEAGRDATIPLQARKGRASYLGERSVGHQDPGATSAALLVRAARRALR
>NZ_CP046172.1|WP_167477598.1|8369283_8370285_+|dihydroxyacetone-kinase-subunit-DhaK
MKKLINDPAEVVDDALAGMAAAHPELRIDEKNRLVLRAEPPKPGKVGLVSGGGSGHEPLHGGFVGPGMLDAACAGEVFTSPVPDQIVAATTAVDAGAGVLHIVKNYTGDVMNFDMAAELAAAETGGEVVAVVVNDDVAVQDSLYTAGRRGVGGTVLVEKIAGAAAEQGRSLAEVAAVARTVNENSRSMGMALTSCTVPAAGKPTFQLGDGEMEIGVGIHGEPGRERVPLAPARAVAEMLVAPILSDLPFRQGDSVICFVNGMGGTPLIELYVMYNEVARLLRGHGIEVARSLVGPYITSLEMAGCSVTLTKIDDELLRLWDAPVRTPALRWGV
>NZ_CP046172.1|WP_167477597.1|8368427_8369168_-|IclR-family-transcriptional-regulator
MIQSVDRAVRILFALQGARRMTLSELAAELGLPATTVHGIVRTLAAHGVVVQERGGGRYQLGPAVLRLGNVYLDTLDLRARSLTWAHELARRTGLAVRVGVLFGDDVVIIHHEPRQDGSRQMPELGIEIPAHASALGKAVLAFHPPAAPGPLRSMTGETIIASEVLAECLTAVRESGLAYERDEAVLGESSIAGAIFDRTGTAVGAVGVVLPTADWPAAPDIVDAVRATARTISRELGSAKWPVLP
>NZ_CP046172.1|WP_167477596.1|8366582_8368373_+|long-chain-fatty-acid--CoA-ligase
MREFEVPASYTIPEDANMSDGAFRHAEQTPGLVVFNKPDGKGGWTDITAKEFAATVTGVAKGFIAAGIELGDRVAILAPTQYEWVVLDFAIWAAGGCTVAIYDSSSAEQAKWILQDSATKLLIVENAKHRATISEIEGDLPALRETLLLEKGAIADLTARGADLDDQVVHDRRAQVKAASPATLIYTSGTTGRPKGVMLSHANMYAESAADRSAMSEFLRPGNKSLLFLPLAHVFARAVALAAFDAGVTVAHSADWSTLVEQFGAYKPDFILSVPRVFEKVFNAAKQKAHDGGKGKIFDAAADTAVAYSEALQSGGPGLVLKLKHALFDRLVFGKLREALGGRCLSAVSGGGPLGARLGHFFRGAGVTIYEGYGLTESTAAFSVNTPKHIRVGTVGRPLPGHAAAVAEDGELLLRGPVVFNGYWGNAEATEDAFVDGWFKTGDLGAIDDEGFITITGRKKEIIVTAGGKNVSPGMLEDDLRTAPLISQVMVVGDGEPFIAALITLDPEALPGWKERNNVAADTPIEQVIENPALVAEINAAVAEANKKVSHAEAIKKIRILPVDWTQETGELTPKMSLKRAVVMKKYADEVAKIYS
>NZ_CP046172.1|WP_167477595.1|8365605_8366529_+|alpha/beta-hydrolase
MRDIALPLPVAKAVLRPIYGVTLNKRLPWRTQRLLLELSSRAQPVPSGTVVHKLRLGGRPAERLTAGSGIPDAAILYLHGGGYAVGSPLTHRSMTARLARETDCAVYALDYRLAPEHPFPAALDDAEAAFAELVAIGYPPERIAIAGDSAGGGLSLATAQRLIAEHDQTPAALGLIAPWTDPNEIPSGERDLVINKGWSRACAAAYLGENPSTAAGYAPLHGRLAGLPPTYVQVDVSELLHGQCVTFVAALRAAGVPVTFTESRGLWHVAQIQAALVTGAAAALSELAEFLRDAVHPVNRRSDQAAR
>NZ_CP046172.1|WP_167477594.1|8364753_8365587_+|SDR-family-NAD(P)-dependent-oxidoreductase
MSKDAYFRGKVCVITGAGSGIGRALAENLARRGAKLALSDIDTEGLAETVRRCEKFGAEVKSDRLNVAEREAVLLYADEVKKHFGVVHQIYNNAGIAHYGDVMKSSFKDVERIMDVDFWGVVNGTKAFLPYLVESGAGHVVNVSSLFGIIAIPGQSAYNAAKFAVRGFTEALRQEMLVEKAPVKVTCVHPGGIKTAVARNSTVVEGVDQRSAAALFDKYLAIHTPEMAAETITEGVRKGHGRVLIGWEARLLDALVRTTGAGYHRLVAFTTRGFLPR
>NZ_CP046172.1|WP_167477593.1|8363218_8364757_+|NAD(P)/FAD-dependent-oxidoreductase
MSRKVTDNAVGNRPTRHAKTIIIGSGFAGLGLAIRLAQQGRTDFLVLERGSEVGGTWRDNTYPGAACDVPSHLYSYSFALNPNWSRSFSKQGEIQEYIRGVAKRHRVLDKHIFDCDVTAARWNDAAAHWEIESSQGSFTAETVISAVGALCEPALPDIKGINAFEGQICHSARWNHDADLTGKRVAIIGTGASAIQIVPSIAPKVAHLDVYQRTAPWLLPRMDRPYLLPERLAFKYLPGVQRLSRAAIYAIRETQVVGLAKFPPLMQAFELVAKAKLRAEIHDPELRAKVTPNFRIGCKRMLISNDYYPALSRDNVDVVTDGIREIRAHSVVTKDGTERDIDALIVATGFHVTDSPTYNTISGRDGRTLAEVFDEIGQQGYKGSAINNFPNMFFLLGPNVGLGHTSMIYMIESQINYIADALATVDRMGLCTVEVRREVQDTYNRDLRRKMANSVWMNGGCSSWYLDKHGNNTTLWPDFTFEFRRLTKKFDVTAYDTTTVASRPDLKVVAAQ
>NZ_CP046172.1|WP_167477592.1|8362516_8363149_-|TetR/AcrR-family-transcriptional-regulator
MSGRGAGENGRRVRLSPEERRLQLITLGVEMLGDRALEDISISEIAEQAGISRGLLFHYFPTKQDFQLAIVQHANGQLLERIAPDRSLPIPEMLRDSIARYVDYVGENRAPYTALLRGPASTSPELLGLVDQTRDTIIGIILTEAPVSASADQPRLKLAMRGWIAFVEETTLTWLRSEPIPRASLIDLLVESLLALALSLNPELAAALRG
>NZ_CP046172.1|WP_167477602.1|8376928_8378413_-|DHA2-family-efflux-MFS-transporter-permease-subunit
MSTQRNPWLALFALVVGFFMILLDMTIVAVANPAIMTSLQTDINKVIWVTSAYLLTYAVPLLVTGRLGDRYGPKNLYLIGLTVFTAASLWCGLSRSIDMLIAARAVQGLGAALMTPQTMAVITRTFPPDRRGAAMGLWGGVAGLATLVGPILGGVLVDGLGWEWIFYVNVPIGIIAFGLAMWLVPALPTHPHKFDIPGVVLSALGMFLLVFGIQEGNTRDWDGVIWALIAAGVLVLVAFVYYQSRSTGEPLVPLGLFKDRNFALSSVAIATMGAAVTSMMVPSYFFLQGVRDMSPTRSALVFAPMAIITGVLAPGIGKAADRLHPRIVPTIGFALYAASVFWFAALMKPHTSIGWFLVAAAVAGVANACIWAPLASTATHNLPVQQAGAGAGIYNTTRQVGSVLGSAAISSLISARLTANGLGGGKISEAGAAHMTMPEFIKEPFSTALGQSLLLPAGVLLIGVIASALFVRHGKSATNGSKQDSPVKADTFAH
>NZ_CP046172.1|WP_167477603.1|8378505_8379144_-|PadR-family-transcriptional-regulator
MGQQERNAVTPLAIAVLGLLEERPMHPYEMYQLLVSRQQNVLVKVRPGSLYHTVARLADLELVRAEGTGREGNRPERTTYRITERGRTAMRERIAEILRAPAAEYPAFPIGIAEAHNLPMPEVIALLNERLELLHRELAEIDIAGDWAGSRGVPRRYWLVLPYLRAMLTAEIAWVDEFLADLTSGAMEWEQFDATTGDRHGEPCDGHSSKAG
>NZ_CP046172.1|WP_167479757.1|8379304_8380180_-|transporter
MVLAASRRLLVRALVIATAVLAVSCGNGVESGPVVAVGAGDSAESNLLAQIYSGALARAGARTSVVSGLGGRADRLTALDANRVQLFGEHTGALLAELDSSSDARTPGEVNQALNRALPAGTVVADAADGTDMRPRVLTTAAVGVHSVAELAAHCDGRAIGVAPVPGLLELPAELLRIPGCAAPVPLPDPAALRKALLDGSIQVGLLSGPPIDPADTDGLVVLADADYAVRAENVIPLFRKGLLDDRRVKKLNYVAGELNTGDLSAMVRRMRDERAQPADLARDWLDQHGL
>NZ_CP046172.1|WP_167479758.1|8380399_8381284_+|ABC-transporter-substrate-binding-protein
MILSACGNSNPLANKGDCSGDGIKVGSANFPESETVADVYAEALRANGFNVDTKLGIGSREAYVPAVKSCAISVIPDYTGNLLQYLDKNSTASDATAIDAALRTALGSDLSIGTPAPGQDSDAVVVTKATADRWNLHTIADLAPHSAEVKFGAPAEFAERAGGLPGLKKNYGLDVAAGNFVPILDGGGPATVKALVDGQVTAANIFTTSPAIKQNNLVVLDDPKHNFPAQNVVPLISTAKKTDKLLTVLNAVSAKLTTDELVKLNEAVSGDSKTEPKAAAAAWVAAQGLNKPVG
>NZ_CP046172.1|WP_167477604.1|8381296_8382439_+|ATP-binding-cassette-domain-containing-protein
MSDIEFRGISKTYPDGTHAVTDLDLRIESGSFTVFVGPSGCGKTTSMRMINRMIQPTAGSITVAGQDISTVDPVKLRLGIGYVIQSGGLLPHRTVVDNVATVPVLRGDSRRAARAAALEVLDRVGLDRSLAGRYPAQLSGGQQQRVGVARALAADPPVLLMDEPFSAVDPVVRAELQTEMQRLQAELQKTIVFVTHDIDEAITLGDRVAVFGRGGVLQQYDAPQEVLAQPATDFVAGFVGRDRGYRGLSFRSADSVPLHEIQTATAETIAAHRLERGDWVLVVDADRRPMGWVDVTGVEGLRAGQPLADSMSAGGSLFTPTGDLRQALDAAISSPSGIGVAVDDSGAVRGGVLATEVVEQLAGQRATEDAERNRHYFDKG
>NZ_CP046172.1|WP_167477605.1|8382443_8383112_+|ABC-transporter-permease
MRYLIDNFAEIMGFTRTHLYLALVPLILGLVIAIPLGALLRRVPWLRRVTVTAASLAYTVPSLALFVIIPPLIGTSTIDPLNVIIALTVYSTALLVIAVPAALDSVPATVLDAADAVGFGALRRMLTVDMPLAVPVFVSSLRVVVVTNIAMVSVGALIGVGGLGKLFTQGYQRDYPDEIIAGIIVTLALALIADRLVYVLGRIATPWTRADARATRVKGTQA
>NZ_CP046172.1|WP_167477606.1|8383108_8383795_+|ABC-transporter-permease
MNLFLDAWHYLTDGANWGGSTGIETRIGQHIWYSFLAVALSAVVAVPLGLVIGHTRRGSALLVGFANAMRALPTLGLLTFLVLLLGLGLIPPLLALITVGIPPLLAGAYAGIANVPADVVDASRAMGMNERQILFRVEIPNALPILLTGLRGATLQVVATATIAAYVNLGGLGRYIFDGISLYRYDRVLVGALLVAVLAMLLDGLLAFATWATTPGTGRLRRAPRANS
>NZ_CP046172.1|WP_167477607.1|8383808_8384996_-|DUF1501-domain-containing-protein
MPHVSRRQFLVGSGVLGALGLAGGSLVSWEELRHRAQTSPLPPNSGILVVLTLYGGNDGINTVIPYADNAYHDARPELSYRPDEVLHLDDQLGLNPAMKGFTELWKQRNLAIVRGVGYPHPDHSHFRSMDIWQTASPDSPVSTGWIGRWLDATGDDPIRAVNIGPVLPQLALGEKHTAAALDPNSAPLSPDMSAVLAGLAATDQRDTPSQAAVCLGYRGEQTVAQTFSKLVAGKKNANPLAAQLDLVGKCIKAGVPTRVYSVSLGGFDTHADERRTQQELLGRFDEAVSAFLKDIAGHPRGRDVVLMAYSEFGRRVAANASQGTDHGTAGPMFVAGQSIKGGFYGDEPSLKDLDNGDLKTTVDFRDVYAELMHRVIDTDPGPAVGGPRHDLGLIA
>NZ_CP046172.1|WP_167477608.1|8385013_8386330_-|DUF1800-domain-containing-protein
MGTQSAQWIHTARMLRRAGFGATGPEIDAVQRQNPADYLRAALAADPDADPGAQATPLPVYAKPKAPGKAAQVVERKQYRAQLTDQLTGITVWWLRRMAAVRQPVHEKLTLLWHNHFATSAAKVRDARALVAQNQKFRTLGTGDFGALAYAMLTDAAMLRWLDGTSNSAKAPNENLSREFMELFALGHGNGYTETDVREGARALTGWTIDGNDAVTLNAKRHDSGSKTLLGVTGSLGAREFCDIVLARPESARYVAGRMWQQLGSDAPPSAQALDRAVAAYGPGRNGAALVVAILTDDEFAAAHNTVVHGPIEWLVGAVRALGVPLTADADAQKLTGVLRSLGQLPFYPPNVGGWPRGQAWMSTAAAQIRLTAATALVKKADLSRISSTAPADRIDAVGYQLGIGAWSDRSAKVLATMRDDPAKLTAVALNTPEYLTS
>NZ_CP046172.1|WP_167479759.1|8386447_8387656_-|NADP-dependent-malic-enzyme
MTDAPNATASLSEITHDEIFAGHLGGKLSVELSAPLDNQRDLSIAYTPGVAQVSRAIAKDDALAKRYTWTDRLVVVVSDGTAVLGLGDIGPRASLPVMEGKAALFKKFAGLNSIPIVLDTKDVDEIVETLIRLRPSFGAVNLEDISAPRCFEIERRVIEALDCPVMHDDQHGTAIVVLAALNGAAKVQGRAINGLKVVVSGAGAAGVACTNILLAAGVEDVTVLDSKGIVSRDRGDLNAVKAELAQRTNPRGLTGGAAEALAGADVFLGLSAGLIAEELIASMAPESIVFAMSNPDPEIHPEVARKYAAIVATGRSDFPNQINNVLAFPGVFKGALDAGARRITEGMKIAAADAILSVVADELGPEKIVPSPLDPRVARPSPRPSRPPPARRALRNKPFSAK

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP046172_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046172_16

8647837-8647956

Orphan

Consensus_repeat	Method
CGGTCACGGCGCGGCCGAGCCCAGCGAGGACGCGACGTGACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046172_16

>merge|NZ_CP046172|16|8647837-8647956|CRISPRCasFinder
CGGTCACGGCGCGGCCGAGCCCAGCGAGGACGCGACGTGACCGAGCGCAGCGAGGGCACCAATAGGCGCAGCACCAGCGGTCACGGCGCGGCCGAGCCCAGCGAGGACGCGTCGTGACCG

>NZ_CP046172|16|16|8647837-8647956|CRISPRCasFinder
CGGTCACGGCGCGGCCGAGCCCAGCGAGGACGCGACGTGACCG	AGCGCAGCGAGGGCACCAATAGGCGCAGCACCAG
CGGTCACGGCGCGGCCGAGCCCAGCGAGGACGCGTCGTGACCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046172.1\|WP_167477817.1\|8643199_8644342_-\|cystathionine-gamma-synthase	unknown	unknown	gnl\|CDD\|236104
NZ_CP046172.1\|WP_167477818.1\|8644446_8645622_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173840
NZ_CP046172.1\|WP_167477824.1\|8651293_8651743_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP046172.1\|WP_167477820.1\|8646149_8647034_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377524
NZ_CP046172.1\|WP_167477816.1\|8642610_8643105_+\|transcription-elongation-factor-GreA	unknown	unknown	gnl\|CDD\|234693
NZ_CP046172.1\|WP_167477821.1\|8647233_8647656_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167477813.1\|8639764_8640619_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167477822.1\|8649249_8649726_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167477814.1\|8640615_8640891_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167479792.1\|8648021_8649197_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167477825.1\|8651886_8652369_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167477815.1\|8641875_8642310_+\|DUF4307-domain-containing-protein	unknown	unknown	gnl\|CDD\|379491
NZ_CP046172.1\|WP_167477823.1\|8649890_8651027_-\|AbrB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|377472
NZ_CP046172.1\|WP_167479791.1\|8640887_8641754_-\|mycothiol-conjugate-amidase-Mca	unknown	unknown	gnl\|CDD\|132487
NZ_CP046172.1\|WP_167477828.1\|8653771_8655160_-\|cystathionine-beta-synthase	unknown	unknown	gnl\|CDD\|273464
NZ_CP046172.1\|WP_167477830.1\|8655840_8656719_+\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238874
NZ_CP046172.1\|WP_167477829.1\|8655264_8655753_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167477819.1\|8645725_8646082_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167477827.1\|8653361_8653766_+\|SgcJ/EcaC-family-oxidoreductase	unknown	unknown	gnl\|CDD\|274053
NZ_CP046172.1\|WP_167477826.1\|8652421_8653234_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293813

Protein	Function_ID	Function_description	E-value
NZ_CP046172.1\|WP_167477817.1\|8643199_8644342_-\|cystathionine-gamma-synthase	gnl\|CDD\|236104	PRK07811, PRK07811, cystathionine gamma-synthase; Provisional.	0
NZ_CP046172.1\|WP_167477818.1\|8644446_8645622_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173840	cd01151, GCD, Glutaryl-CoA dehydrogenase. Glutaryl-CoA dehydrogenase (GCD). GCD is an acyl-CoA dehydrogenase, which catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and carbon dioxide in the catabolism of lysine, hydroxylysine, and tryptophan. It uses electron transfer flavoprotein (ETF) as an electron acceptor. GCD is a homotetramer. GCD deficiency leads to a severe neurological disorder in humans.	0
NZ_CP046172.1\|WP_167477820.1\|8646149_8647034_-\|hypothetical-protein	gnl\|CDD\|377524	pfam05552, TM_helix, Conserved TM helix. This alignment represents a conserved transmembrane helix as well as some flanking sequence. It is often found in association with pfam00924.	2.77518e-11
NZ_CP046172.1\|WP_167477816.1\|8642610_8643105_+\|transcription-elongation-factor-GreA	gnl\|CDD\|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	2.7742e-63
NZ_CP046172.1\|WP_167477828.1\|8653771_8655160_-\|cystathionine-beta-synthase	gnl\|CDD\|273464	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase. Members of this family closely resemble cysteine synthase but contain an additional C-terminal CBS domain. The function of any bacterial member included in this family is proposed but not proven. [Amino acid biosynthesis, Serine family].	0
NZ_CP046172.1\|WP_167477815.1\|8641875_8642310_+\|DUF4307-domain-containing-protein	gnl\|CDD\|379491	pfam14155, DUF4307, Domain of unknown function (DUF4307). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 132 and 153 amino acids in length. There is a single completely conserved residue C that may be functionally important.	1.48871e-37
NZ_CP046172.1\|WP_167477824.1\|8651293_8651743_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	8.00955e-26
NZ_CP046172.1\|WP_167479791.1\|8640887_8641754_-\|mycothiol-conjugate-amidase-Mca	gnl\|CDD\|132487	TIGR03446, mycothiol_Mca, mycothiol conjugate amidase Mca. Mycobacterium tuberculosis, Corynebacterium glutamicum, and related species use the thiol mycothiol in place of glutathione. This enzyme, homologous to the (dispensible) MshB enzyme of mycothiol biosynthesis, is described as an amidase that acts on conjugates to mycothiol. It is a detoxification enzyme. [Cellular processes, Detoxification].	0
NZ_CP046172.1\|WP_167477830.1\|8655840_8656719_+\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238874	cd01836, FeeA_FeeB_like, SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it turn are loaded onto the acyl carrier protein FeeL. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	5.98104e-50
NZ_CP046172.1\|WP_167477823.1\|8649890_8651027_-\|AbrB-family-transcriptional-regulator	gnl\|CDD\|377472	pfam05145, AbrB, Transition state regulatory protein AbrB. Bacillus subtilis respond to a multitude of environmental stimuli by using transcription factors called transition state regulators (TSRs). They play an essential role in cell survival by regulating spore formation, competence, and biofilm development. AbrB is one of the most known TSRs, acting as a pleotropic regulator for over 60 different genes where it directly binds to their promoter or regulatory regions. Many other genes are indirectly controlled by AbrB since it is a regulator of other regulatory proteins, including ScoC, Abh, SinR and SigH. Hence, AbrB is considered a global regulatory protein controlling processes such as Bacillus subtilis growth and cell division as well as production of extracellular degradative enzymes, nitrogen utilization and amino acid metabolism, motility, synthesis of antibiotics and their resistant determinants, development of competence, transport systems, oxidative stress response, phosphate metabolism, cell surface components and sporulation. AbrB is a tetramer consisting of identical 94 residue monomers. Its DNA-binding function resides solely in the N-terminal domain (AbrBN) of 53 residues. Although it does not recognize a well-defined DNA base-pairing sequence, instead, it appears to target a very weak pseudo consensus nucleotide sequence, TGGNA-5bp-TGGNA, which allows it to be rather promiscuous in binding. The N-terminal domains of very similar sequences are present in two more Bacillus subtilis proteins, Abh and SpoVT. Mutagenesis studies suggest that the role of the C-terminal domain is in forming multimers.	9.80144e-62
NZ_CP046172.1\|WP_167477827.1\|8653361_8653766_+\|SgcJ/EcaC-family-oxidoreductase	gnl\|CDD\|274053	TIGR02246, hypothetical_protein, conserved hypothetical protein. This family consists of uncharacterized proteins found in a number of genera and species, including Streptomyces, Xanthomonas, Oceanobacillus iheyensis, Caulobacter crescentus CB15, and Xylella fastidiosa. The function is unknown.	2.05655e-24
NZ_CP046172.1\|WP_167477826.1\|8652421_8653234_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293813	cd07727, YmaE-like_MBL-fold, uncharacterized subgroup which includes Bacillus subtilis YmaE and related proteins; MBL-fold metallo hydrolase domain. Includes the uncharacterized Bacillus subtilis YmaE and Nostoc all1228 proteins.Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry. .	2.24706e-28

>NZ_CP046172.1|WP_167477821.1|8647233_8647656_-|hypothetical-protein
MPPAPVSPAERTAGTPTAIGILRQDISGRHRRRDERIVEWLAQRWGYELPALLIVDDTELAPTLLLIEHIRAAAADAVIAPDREHIWPARRAVTELCDLILAGSEKTWPRGYHWPPFGYAEDELTVARPRGLTTGYRILG
>NZ_CP046172.1|WP_167477820.1|8646149_8647034_-|hypothetical-protein
MHTSSLAIDFQRGMSDAWSSVATFVPKLAGFLVIMLAGWIIARVVAAVVRRVLDRVGFDRLVERGGIRQLLSRSRYDASDLLAKLAYYAILLIALQLGFGVFGPNPVSSMLNGIVAWLPRAAVAIVVVVIAGAIAHAVREMVTNMLGGLSYGAMLGRIASVFIWGVGIVAALNQVGVATSVTMPILITVLATIGGILIVGIGGGMISPMQQRWESWLSGLEQEMPEVKGHAEAYRRGREDVAREQLWMDQQATRGQQWQEPMTSSGFAQGGQYGQGQQYAQGGYQQYGNPQERR
>NZ_CP046172.1|WP_167477819.1|8645725_8646082_+|hypothetical-protein
MFLLGPALLEVSAHRILTRLHRTHGVPALAAAAQMPALLARLDQHAAAVRDILDVGVPDSAKVPAGVLLAGYVRGLLDEARTGTGMGRAPSDLDEWAEADWLQLRLAGVCLHAARQAA
>NZ_CP046172.1|WP_167477818.1|8644446_8645622_+|acyl-CoA-dehydrogenase
MVTVEELFAIDSLLSDDEREIRDTVAAFAAQRLRPHIAEWFEAGTFPARELAPELGRLGLLGMHLDGYGCAGMSATMYGLACQELEAVDSGVRSMVSVQGSLAMTAIHKFGSEEQKQRWLPEMAAGRAIGCFGLTEPDFGSNPGGMRTRAKRDGADWVLNGSKMWITNGSVADVAVVWAQTEDEGKQVIRGFLVPAGTPGFAAREMHHKLSLRASITAELDLDDVRLPADAVLPESRGLNAPLSCLSEARFGIIFGALGAARDCLAATIEYARTREVFDKPLAAYQLTQAKLADMALEFGKGQLLAVHLGRLKDAHRIRPEQVSAGKLNSTREAIAIARECRTILGANGITLDYPVLRHANNLESVLTYEGTAEVHQLVLGKALTDANAFR
>NZ_CP046172.1|WP_167477817.1|8643199_8644342_-|cystathionine-gamma-synthase
MSELGFSTRAVHAGFDPDPQTGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEANLAALESGSYGRAFASGMAATDCALRAILRPGDHIVIPDDAYGGTFRLIDKVFSQWGIEHSPAHIFNTDEVRAAIRPNTKLIWIETPTNPLLSIGDIPALAEIAHAGGAKLVVDNTFATPYLQQPLLLGADIVVHSTTKYLGGHSDVVGGALITNDKDLDAAFAFLQNGAGAVPGPFDAYLTMRGAKTLALRMERHCDNAEKLAEFLSSHPKISQVIYPGLPEHPGHLLADKQMRRYGGMISVRLHGGRDAAHDFCSRTRIFTLAESLGGIESLIEHPAAMTHASTAGSQLEVPVDLVRLSVGIEDGSDLLADIEQALG
>NZ_CP046172.1|WP_167477816.1|8642610_8643105_+|transcription-elongation-factor-GreA
MTETQVTWLTPESHDRLKSELDALIANRPVIAAEINERREEGDLKENGGYHAAREEQGQQEARIRQLQELLNNAKVGVAPTKSGVALPGSVVKVYYDGDESDTETFLIATREEGLSDSKLETYSPASPLGGALIDAKVGETREYTLPSGKTMKVTLISAEPYHS
>NZ_CP046172.1|WP_167477815.1|8641875_8642310_+|DUF4307-domain-containing-protein
MTESAGGTDLRADRYGIKPRARRRWIPLVLGVIVLLGGFGVAYAYYQNFGPSDIDPEQLGYVVDDDSTITVHLKVTRKNPEQPVVCWVRAMSRDGSEVGRREVLIEPSSSGTVELTTVVKASARPSAGNIYGCSSHVPGYLRAG
>NZ_CP046172.1|WP_167479791.1|8640887_8641754_-|mycothiol-conjugate-amidase-Mca
MAVHAHPDDESSKGAATTARYADEGHEVLIVTLTGGERGSILNPAMDTPGVLERIQEIRREEMAEAARALGVRQHWLGFVDSGLPEGDPPPPLPEGCFALVPLEEATEALVRVVREFKPHVITTYDENGGYPHPDHIRCHEVSMAAFEAAGDPTRFPDAGEPWTPLKLYYDHGFTLARLDTFAAEYERIGEPYPLQEWLDRMRQFRSGRPDGMSRVTTRIECAKYFPQRDDALRAHATQIDPNGVFFAIPMEMQQRLWPTEEFELAKSRVETSLPETDLFAGIEDDIK
>NZ_CP046172.1|WP_167477814.1|8640615_8640891_-|hypothetical-protein
MIMVVLAQTPANPTGPEFGKASPIALVIILILLAGTVLLIRSMNRHIKKLPATFEPEHPEPDQEADEGTEHGVARRESENGADSDHPAGTG
>NZ_CP046172.1|WP_167477813.1|8639764_8640619_+|hypothetical-protein
MPDATEELREVLRRSPFRHRLRTVLHRWYAGYDAPAMPREYQGELVTDDFTIVRPPQFPVRTVTGRAAYLDSLTTAYIGQRNAHHLRGLELAPDMSHATVTHDFETIGPQLTGTIRMRYEIDLVQDPAERLPRFHRLTETILGTDDTPFVDGYGENRVRSFVHYWLSLLEEPAASAAPLRELIADELTPRLDEIATRTTAELGAHHPADLRIDLADPENYRVTMDFEWVGIDASDRPSTARTRHDWTLRESGERYPRLHRYEAEVIEPSTPIPAEDALARALRN
>NZ_CP046172.1|WP_167479792.1|8648021_8649197_+|hypothetical-protein
MTRRELADAVNDHVFRVTNKPGAVDERHVGKWERGETTWPRKHYRAALRAVLNVATDAELGFVRHRQSTDDEDVNRKQFIQGALVIGTGAALSNAAPTEAELIETLGGPTTHFRRMESSVASDRLAPAVEAHLNLVAGVVRDRLRTSNGFRTLSEIAGLAAWLAADRGDDAMARRHYIEAIRYAERTHHPLLVSYMTASLGHYAVETGDGRAGLTLLHRAAAQLGADAPDSASAWLASLLAVAHASTGDRNGALAALQRAERLAERQHGEPQWPWVFAFDGTKAARYQASTLARLGDHRAAKVAFAAAAPALLAEKPRALVQVEHAYVLARSGDIEAGCALAAQSLTIGLAFHSERITRLARDFRASLPGKTAEARPLDEALATLYRPDEP
>NZ_CP046172.1|WP_167477822.1|8649249_8649726_+|hypothetical-protein
MTRVAITGHRGLPADTTALVDRMLRGAVLRRAADLVGVSCLADGPDSLFARAVLDYGGRLIAVVPARTYRAALPVEHHRVYDELLSAAIKVIELDRDESNAEAHLAAGLRMLDEADELLAVWDGAPARGVGGTADVVAAARRRGLPVTVIWPGGATRD
>NZ_CP046172.1|WP_167477823.1|8649890_8651027_-|AbrB-family-transcriptional-regulator
MNRWQIFGWMALLIGVLAAAELLDRVHFPAPQMILAMVVGAVLALSGRLPAPMPRQISVGAQAMLGVLMGSYLEISLLSSIGLAVFPVLAVTLATLVVSVLVAWVFARVSGVDLPTATLGLLAGGSAAVVACADEMDADPRRVAFMQYLRVAMVALSAPALASMLSHGDGLAANARSVTASVTNPDLPHWMLFGRGDQVAGLSIAVMLCVAGIWLGRRLNMPSPALIGPMLITALLTALGVTHGYAPTNLLKDLLFVIIGFEVGTRFTRGVVIEMARMIPGMTLTIVALSGAVAALAFTVALFVDLELSDIYLATTPGGINAVLATAESMNANLPLITSVQSLRLLLMVFALPVLLRLFRYLSDRRAVRERPRELVAH
>NZ_CP046172.1|WP_167477824.1|8651293_8651743_-|helix-turn-helix-transcriptional-regulator
MRYAELADFPCSITRPLVIFGDRWTLLILKFAFAGVRRFNGFQTALGISRGRLQDRLDRLVEHGILEKRRIDGGAYEEYRLTRKGHDIYPVLMAIKDWGDRYMAPDGPPVHYAHRDCSGEARVRLECDCCATEITARDVVPTPGPGIGG
>NZ_CP046172.1|WP_167477825.1|8651886_8652369_+|hypothetical-protein
MGTMIHRVATGLGIAVLLTGCQSADHASVSPSPTTVASHPVDTTPVGATWNVPKAFLGQWKGDAVNGPAITMSIGAGKNSEEIATTSTVDRQSGNRCEHAQRVILVTETELTFSARLLGGAGCAADGATTIVDLRPDGALDYTAPAGPTGTITAVLRRTP
>NZ_CP046172.1|WP_167477826.1|8652421_8653234_-|MBL-fold-metallo-hydrolase
MWKICTTCGVEHDAAAEVCRICADERQWVPAEGQQWTTLAELAATEHRVEVRELEPDLFGLTTAPNIGIGQQALLVRTPEGNLLWDPTAYVDDEAVRRVRELGDAVAIVASHPHMYGVQVAWSHALGGVPVLVAAPDMEWVARPDPVIRPWSGQVDLLPGVILRQVGGHFPGSAVVHWSAGAGGRGVLFSADTIKANPDRVTVSFLRSYPNRIPLSAAVVDRITKSVEEFEFDRLYDNFGMTIDTDARAAVRRSADRHIAWVRGDFDHLT
>NZ_CP046172.1|WP_167477827.1|8653361_8653766_+|SgcJ/EcaC-family-oxidoreductase
MAGMTSATAELDAIHAVVAAVDRAQRAEDADAFIELFHPDAIWTTGAGKFLDGRDEIAAFTRTVLPGATKDGYATYEPFLVRFIRTDVAVVKVRQRYWSNDGELQSEGSPLYGMTKENGRWLLTFCQNTPVADH
>NZ_CP046172.1|WP_167477828.1|8653771_8655160_-|cystathionine-beta-synthase
MRIADHVVDLVGNTPLVRLNSVVEPEAGLVAAKIEYLNPGGSSKDRIAVKMVDAAEKSGQLRPGGTIVEPTSGNTGVGLALVAQRRGYKCVFVCPDKVSEDKRNVLRAYGAEVVVCPTAVPPDHPDSYYSVSDRLVREIPGAWKPDQYSNPNGPDSHYETTGPEIWRDTEGKVTHFVAGVGTGGTITGTGRYLKEVSGGKVKIIGADPEGSVYSGGTGRPYLVEGVGEDFWPSAYDPSIPDEIIAVSDADSFDMTRRLAREEGLLVGGSCGMAVVAAIEVARREPDAVIVVLLPDSGRGYLSKIFNDQWMSSYGFLRTRLDGSIAEPLVGDVLRGKSGALPDLVHTHPQETLRDAIEILREYGVSQMPVVGAEPPVMAGEVAGSVSERDLLSAVFEGRAHLTDSVAQHMSPSFPLIGAGEPISAATKALSDTDALMVVEDGKPVGVITRHDLLGFLSTGSIG
>NZ_CP046172.1|WP_167477829.1|8655264_8655753_+|hypothetical-protein
MRLPNLVCAATVLAGSAVAAAVGSGADAAAATVQLPQVPTLAHGGLCWTTIRTWADTSPAWPGRAIINVRADPVSGIGPGDYPLAPLCEIPTRVSWRNTSTGATGVYENDVVTGIYGSLQYALFQDTGPGHVELTVTTDAPSIPANGSIEVPGPPPAPPAPR
>NZ_CP046172.1|WP_167477830.1|8655840_8656719_+|SGNH/GDSL-hydrolase-family-protein
MGAPRIGWRTAAVTSAATVLAGSGAGTGAWAAYRLLMSQAGVARGVIGQDTSKPPEADGIYTAGCLAPQRWRIGLHADLHMMIFGDSTAAGVGCLTAEEVPGVRLARGLAEATGQRIRLSTKAISGATSKGLSGQVDAMFVAGPPPDVAVILIGANDITKKHSVLQSARRLRSAVARLRQAGAVVVVGTCPDLGTVTAIPQPLRTVVHSWSVRLARAQTAATLAAGGQPVKMGRLIGREFLAEPDRLFAADGFHPSAAGYELAAAHLLPVLVGALAQWDSRAAAVPSQPAAT

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP046172_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046172_17

9418633-9418730

Orphan

Consensus_repeat	Method
ACCCGGGCGATCATGACTGCCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046172_17

>merge|NZ_CP046172|17|9418633-9418730|CRISPRCasFinder
CCGCCGGTGATCATGACCGTCGCCCTTCGTCAGCGGCCGGACAGCAGGCCTCCGATTGTCCAGCGGGCTCGACACCGCCGGCGACCACGACTGCCGCC

>NZ_CP046172|17|17|9418633-9418730|CRISPRCasFinder
CCGCCGGTGATCATGACCGTCGCC	CTTCGTCAGCGGCCGGACAGCAGGCCTCCGATTGTCCAGCGGGCTCGACA
CCGCCGGCGACCACGACTGCCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046172.1\|WP_167478414.1\|9413259_9413769_+\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|281995
NZ_CP046172.1\|WP_167478417.1\|9415761_9416205_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP046172.1\|WP_167478411.1\|9408927_9409200_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167478421.1\|9418803_9419220_-\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238780
NZ_CP046172.1\|WP_167478413.1\|9411032_9413105_-\|phosphate-acetyltransferase	unknown	unknown	gnl\|CDD\|235537
NZ_CP046172.1\|WP_167478418.1\|9416234_9416873_-\|glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153234
NZ_CP046172.1\|WP_167478425.1\|9422493_9422640_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167478430.1\|9427121_9427466_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167478426.1\|9422857_9423952_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|224717
NZ_CP046172.1\|WP_167478427.1\|9423994_9424801_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223377
NZ_CP046172.1\|WP_167478424.1\|9421615_9422488_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238636
NZ_CP046172.1\|WP_167478428.1\|9424934_9425510_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP046172.1\|WP_167478423.1\|9420166_9421555_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|215457
NZ_CP046172.1\|WP_167478419.1\|9416933_9417377_+\|RpiB/LacA/LacB-family-sugar-phosphate-isomerase	unknown	unknown	gnl\|CDD\|376799
NZ_CP046172.1\|WP_167478416.1\|9414961_9415759_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319832
NZ_CP046172.1\|WP_167478412.1\|9409703_9410909_-\|acetate-kinase	unknown	unknown	gnl\|CDD\|234680
NZ_CP046172.1\|WP_167478429.1\|9425553_9427059_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP046172.1\|WP_167478422.1\|9419385_9419832_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167478415.1\|9413817_9414828_-\|glucose-6-phosphate-dehydrogenase-(coenzyme-F420)	unknown	unknown	gnl\|CDD\|213827
NZ_CP046172.1\|WP_167471253.1\|9409274_9409562_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP046172.1\|WP_167478414.1\|9413259_9413769_+\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	gnl\|CDD\|281995	pfam04075, F420H2_quin_red, F420H(2)-dependent quinone reductase. This family of proteins is found in the genera Mycobacterium and Streptomyces. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. Rv1558 is an F420H(2)-dependent quinone reductase involved in oxidative stress protection.	5.72216e-25
NZ_CP046172.1\|WP_167478417.1\|9415761_9416205_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	5.63431e-13
NZ_CP046172.1\|WP_167478421.1\|9418803_9419220_-\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238780	cd01522, RHOD_1, Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins.	1.05688e-42
NZ_CP046172.1\|WP_167478424.1\|9421615_9422488_+\|amidohydrolase-family-protein	gnl\|CDD\|238636	cd01311, PDC_hydrolase, 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most important intermediate metabolites in the bacterial pathways for various phenolic compounds, including lignin, which is the most abundant aromatic material in nature.	5.09926e-45
NZ_CP046172.1\|WP_167478413.1\|9411032_9413105_-\|phosphate-acetyltransferase	gnl\|CDD\|235537	PRK05632, PRK05632, phosphate acetyltransferase; Reviewed.	0
NZ_CP046172.1\|WP_167478426.1\|9422857_9423952_+\|CoA-transferase	gnl\|CDD\|224717	COG1804, CaiB, Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion].	1.54334e-103
NZ_CP046172.1\|WP_167478427.1\|9423994_9424801_-\|SDR-family-oxidoreductase	gnl\|CDD\|223377	COG0300, DltE, Short-chain dehydrogenases of various substrate specificities [General function prediction only].	1.37071e-90
NZ_CP046172.1\|WP_167478428.1\|9424934_9425510_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.67963e-07
NZ_CP046172.1\|WP_167478423.1\|9420166_9421555_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|215457	PLN02852, PLN02852, ferredoxin-NADP+ reductase.	5.89063e-132
NZ_CP046172.1\|WP_167478418.1\|9416234_9416873_-\|glutamine-amidotransferase	gnl\|CDD\|153234	cd03140, GATase1_PfpI_3, Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. PfpI is an ATP-independent intracellular proteases which may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.	1.55822e-62
NZ_CP046172.1\|WP_167478419.1\|9416933_9417377_+\|RpiB/LacA/LacB-family-sugar-phosphate-isomerase	gnl\|CDD\|376799	pfam02502, LacAB_rpiB, Ribose/Galactose Isomerase. This family of proteins contains the sugar isomerase enzymes ribose 5-phosphate isomerase B (rpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB).	2.95161e-35
NZ_CP046172.1\|WP_167478416.1\|9414961_9415759_+\|HAD-family-hydrolase	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.64605e-118
NZ_CP046172.1\|WP_167478412.1\|9409703_9410909_-\|acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NZ_CP046172.1\|WP_167478429.1\|9425553_9427059_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	3.32276e-82
NZ_CP046172.1\|WP_167478415.1\|9413817_9414828_-\|glucose-6-phosphate-dehydrogenase-(coenzyme-F420)	gnl\|CDD\|213827	TIGR03554, F420_G6P_DH, glucose-6-phosphate dehydrogenase (coenzyme-F420). This family consists of the F420-dependent glucose-6-phosphate dehydrogenase of Mycobacterium and Nocardia. It shows homology to several other F420-dependent enzymes rather than to the NAD or NADP-dependent glucose-6-phosphate dehydrogenases. [Energy metabolism, Pentose phosphate pathway].	0

>NZ_CP046172.1|WP_167478419.1|9416933_9417377_+|RpiB/LacA/LacB-family-sugar-phosphate-isomerase
MRIAVAADERVGVATELSAELEKRGHETTLHGALSATERDDWAWASEAAAREVAEGRADQAIVCCWTGTGASIAANKVSGIRAALCADGATAAGARNWNDANVLALSLRSTSSAELREILDAWFGAAPSADAADQANIAHLADIENS
>NZ_CP046172.1|WP_167478418.1|9416234_9416873_-|glutamine-amidotransferase
MMKTVHMAVYDTLADWEVGAAVAHINGNHQWHREPGAFQVKTVGPTREPVTTMGAVRIVPDLALDELRPGDSEMLILAGAQTWESGALAQFTHKAREFLDAGVPVAGMCGATFGLAAAGILDDIAHTSNAPEYLAYSGYSGGAHFVRQPAVTDRNVITASGTAPFEFAREVLGRLDVYEPHILDAWYGVYGKGDAAAYAVLADYAAGQRAHA
>NZ_CP046172.1|WP_167478417.1|9415761_9416205_-|MarR-family-transcriptional-regulator
MTEQRLFSTAAITTFKLNGQFLAIAEELARPAGLTAAWWQVLGAVLHTPLPVAGIAREMGITRQSVQRIADLLVDKGLAEYRDNPAHRRAKLVAITDAGRAAIARITPRHAVLADRLATELGAEQFALTVEVLTKLSAALDAIGEPD
>NZ_CP046172.1|WP_167478416.1|9414961_9415759_+|HAD-family-hydrolase
MTAAAEPILSYLTDMDGVLVHEDHLVPGADKFLAELRDNGTPFLVLTNNSIRTPRDLQARLRHTGLDIPEEAIWTSALATATFLDEQRPHGTAYVVGESGLTTALHDIGYVLTDSDPDYVVLGETRTYSFEAITTAIRLVERGARFIATNPDPTGPSREGSLPATGSVAALITRATGRDPYYVGKPNPLMMRSALRRIGAHSQSAVMIGDRMDTDVVAGLEAGMRTILVTSGISTRGSVEQFPYRPTMVLDSVADLVGRTANPFD
>NZ_CP046172.1|WP_167478415.1|9413817_9414828_-|glucose-6-phosphate-dehydrogenase-(coenzyme-F420)
MGELKLGYKASAEQFGPRELVEIAVLAEEHGLESATVSDHFQPWRHKGGHAPFSLAWMAAVGERTKRIQLGTSVLTPTFRYNPAVIAQAFATMGLLYPQRVMLGVGSGEALNEIATGYTGEWPEFKERFGRLREAVDLMRALWTGERTDFDGQYYKTVGASIYDVPKGGIPVYIAAGGPLVARYAGRAGDGFICTSGKGMDLYTEKLMPAVAEGAAKAGRTVDDIDRMIEIKLSYDTDPELALENTRFWAPLSLTAEQKHSITDPIEMEAAADALPIEQIAKRWIVASDPDQAVEQIKPYIDAGLNHLVFHAPGQDQKRFLELFERDLAPRLRALG
>NZ_CP046172.1|WP_167478414.1|9413259_9413769_+|nitroreductase-family-deazaflavin-dependent-oxidoreductase
MADQFPDRQWGSRTNAVSRLANKFAATKPGSWLIRKITPLDRAVLERTDAKYTVLGPIGAPVILLTTTGRKSGAARTQPLLYVHGGDVLYVIGSNFGQAHHPAWTANLLANPAATVAIAGQRIPVTATLLEDDAEKERIFALFADITDAYAAYRNRTTRDLRIFALHRA
>NZ_CP046172.1|WP_167478413.1|9411032_9413105_-|phosphate-acetyltransferase
MSENAPSTVYIASPEGDTGKSTVALGVLQMLCATTARVGVFRPITRSTTEPDYILELLLEHSTADIDYQQAIGVTYEDVHADPDAAISDIVMRFHDVAKVCDAVVVVGSDYTDVASPSELRFNGRIAANLGAPTLLVLRGSGRTPEAVKQLAELCTAELVHEHAELAAIVVNRCDPRQLDEVTAVLKPFGVPSWSLPEVPLLFAPTMAELCQAIDGEMYSGDQELLQREALEVMVGGMTAEHILERLVDGVVVIAPGDRSDVLLSVMNAHEAEGFPSLSGIIMNGGMLPHPAVARLMAGLRAKLPILTTALGTYETTSAVHGTRGRMSAGSPRKVDTALALMEQHVDAPELLRRIEVRLSNVVTPQMFEYQLIERARADRKRIVLPEGDDDRILRAAGRVLQRKIADLVILGDEATVRARAAELGVDIRAAEVLDPRNSGYLEEFAAEYTKLRAHKGMTLERARETISDISYFGTMMVHRGIADGMVSGAAHTTAHTIRPSFEIIKTVPGVSTVSSVFLMCLADRVLAYGDCAVVPDPTSEQLADIAISSAGTAARFGIEPRVAMLSYSTGESGSGADVDKVRVATKLVRERAPELLVEGPIQYDAAIDATVANTKLPDSQVAGRATVFVFPDLNTGNNTYKAVQRSAGAIAIGPVLQGLRKPVNDLSRGALVADIVNTIAITAIQAQQD
>NZ_CP046172.1|WP_167478412.1|9409703_9410909_-|acetate-kinase
MGAENLVLVINSGSSSIKYQLLDPGSGVLAASGIVERIGEDTGGIEHHADGRTIEHSGRIADHTAGLRSVFDMFAETGHDLRRAGVHAVGHRVVHGGEVFYRPTLIDDAVVAAISELSALAPLHNPANVAGIESARQLLPGVPQVAVFDTAFFHGLPAAAKTYAIDAKVAAAHGIRRYGFHGTSHEYVSGQAAALLGRDPAELNQIVFHLGNGASASAVRGGRPIDTTMGLTPLEGLVMGTRSGDLDPGIVPHLMRSAHLSIDEVDALLNRDSGIKGLSGVNDFRELQRLIDAGDEQARLAYDVYIHRLRRYLGAYLIELGGVDAITFTAGVGENSPQVRADALAGLGHFGIEVDQTRNTAKNRAARYISPDGAPIAVLVVPTNEELAIARAAAQVVAETA
>NZ_CP046172.1|WP_167471253.1|9409274_9409562_+|hypothetical-protein
MRRSRPDDEPLDYREHLQAEFNIQFTNAMAGKGVSMCTDLDLETQEVLARIAGHYPDIPPELIDAAHAVFAGQLDGSRDDEDIVPSFVTGRATNE
>NZ_CP046172.1|WP_167478411.1|9408927_9409200_+|hypothetical-protein
MSRASRYLSESQLRATFDRELSRALRGEGARNHSGLDFDTYRALARVAGAYPNIPPELIEAARTAFSGQLDGSNRAARPKLSFEPGELNS
>NZ_CP046172.1|WP_167478421.1|9418803_9419220_-|rhodanese-like-domain-containing-protein
MSYAGDITPRQAWEILRENPEAVLVDVRTEAEWKFVGVPDTSSIDRPTVLVEWVDSRGARNPEFAEELNKALAGRGADAPVVFICRSGQRSANAARVATSLGIEPSYNVLEGFEGGLDADGHRGSEGWRAAGLPWRQS
>NZ_CP046172.1|WP_167478422.1|9419385_9419832_-|hypothetical-protein
MTDKQPAADDGEVIEIDQTDRRSLWPFIAAACFAAVVLVAIVLGGLLSPAEKNVTTADRVAGSVRDFVSGVNNTDSPAAPGSVCQGFDPKRSPLADRPSGKTVEITKIENPIADGDRAKADVTVKIDGNERTTTWNLTRSGDRWLVCD
>NZ_CP046172.1|WP_167478423.1|9420166_9421555_+|FAD-dependent-oxidoreductase
MTEQSVGPRPLRIAIVGAGPAGIYAADALMKSDADVSIDLFERMPAPFGLIRYGVAPDHPRIKGIITALHKVLDKPQVRLLGNIDYGVDITLDDLRVYYDAVIFSTGANADRALDIPGIELDGSFGAADFVSWYDGHPDVPRTWPLDAEKVAVLGVGNVALDVARVLAKTGDELLPTEIPPNVYAGLRANKAVEVHVFGRRGPAQAKFTPLELRELDHSPTIEVIVDPEDIDYDEGSEAARRHSKQVDMVANTLEQWAIRDQGDRPHKLFLHFFESPAEVLGADGKVVGLRTERTQLDGTGNVKGTGEFREWDVQAVYRAVGYLSQNITNLPFDEQAGTVPNEAGRVLLDENADGAARYLSATYVTGWIKRGPVGLIGHTKGDANETVACLLDDSPNFTPAAKPDPEAVVEFLEGKGIPFTTWDGWYRLDAHERALGEPEGRERVKVVEREDMLRASEPHKV
>NZ_CP046172.1|WP_167478424.1|9421615_9422488_+|amidohydrolase-family-protein
MFDAHVHIIDPRFPLVENEGYLPKPYTIADYRKRMSRFDIAGGAVVSGSFQGTDQTFMKAALAELGEGWVGVIALDLDATDSEIVELDRIGVRALRFNLKRAAADITEMTLQALRAHDLVGWHVEVYIDGQMLASLQPVISKLPVFCVDHLGMSDACLDYLLDLVDQGARVKASGFGRVSMNVADTLRRIHAVNPGALMFGTDLPGTRAGRPFRDADIDLICDVVGTDMHAVLEDNAREFYRLPARERPTPADPEPTLPLPGAYQPTLPLRRDELPKPEAADTIPFRAID
>NZ_CP046172.1|WP_167478425.1|9422493_9422640_-|hypothetical-protein
MRSRLVPAFVAAVVLGLFAAASAYIRICTRAFRSAAAVHGPGSWYDRR
>NZ_CP046172.1|WP_167478426.1|9422857_9423952_+|CoA-transferase
MTTPSTRQGPLAGIRVVELAGIGPGPHAALLLADLGADVVRVQRPNLLPGFMERPQWRGRTIVEANLKDPADIERVLGLIAKADVLIEGFRPGVTERMGLGPDEALARNPRLVYGRMTGWGQSGPLADRAGHDINYISLTGVLNAIGHKGERPVPPLNMVGDFGGGSMFLVFGILAALVERQTSGKGQVIDAAMIDGALALSHMIWGMRGMGLWSDERGANLLDTGMAFYDTYETADGKYMAVGAIEPQFYAELLRGLEIDPDGLPMQIDPNGQEQLKKLFTEKFKTKTRDEWTAIFDGTDACTTPVLTFTEAERNPHIVARTGLIEIDGVVQHAPAPRFSRTPAGTPTPPPNEATPIESIWAD
>NZ_CP046172.1|WP_167478427.1|9423994_9424801_-|SDR-family-oxidoreductase
MTQSTKTALVTGASSGIGAEFAAALVARGDAVILVARSADRLEAVAAQLRSRYHGEVHVIAQDLTEPDAAERIANELAARSISIDILVNSAGFGSAGRFEELSADGEQAQLMVNVVALAALTRRLVPGMLTRGAGEIINVASTAAFQPAPYFATYAAGKAFVLNFSLALWSEYRGRGIKVLAVCPGPTETAFFDVVGTRDAAIGGRIGTAAQVVSASLRALERDRGYVVPGFQNFASAHLMPRRPRAMVARIAKQITRGVADAATRAA
>NZ_CP046172.1|WP_167478428.1|9424934_9425510_+|TetR/AcrR-family-transcriptional-regulator
MTRTSTRPMRADAERTVRTILAAAERVLGQNPSATLEQIAEAAGVARTTVHRRFANRDDLLRTMSRNSWQRIVAAVDAARPNTAPPLVALHQATANVIEIKYGAKFALDQADPADREVVALQADVFAKCDVVLTRAQESGAIAPDADLDWVRRVYLALIAETVHGAAEPTSDPDALAGRVIETLLHGFGPR
>NZ_CP046172.1|WP_167478429.1|9425553_9427059_-|PLP-dependent-aminotransferase-family-protein
MATRVIGASSLARDLGHWRSAEDGERGEVTRRSARPAYLALAEGIRLLIHDGRAPLGVALPSERDLATTLGVSRTTITSTYALLRENGYLISRQGSRSTVALPPAVPHDGMKPTRGIMATMPHSALPTIDMTYAAMAAPLEMQDAYAAALEGIPAYLCTHGMDPVGIVALREALARRYTERGLPTEPDQILVTLGAQHGLRLLLNVLASPAARVLIDHPTYPNAIEAIRDVGARPIPVPVRPELPGSGWDLDGIRSAARQTAATLAYLVPDYNNPTGLLMNNEDRAELAAIARETRMTVVIDESMVDLRLTAAEPPLPVAAFAKGSEIVTIGSASKSFWGGLRVGWIRTNQALITKLLGIRSTVDLGTPVMDQLAVGYLLEHAETILDRRRGQLRSQRAALLSALAEELPDWRVTDTAGGMSVWAQLPAPVSTALAATAPNHGILLAAGPRFGVQGAFERFLRLPFTHQEHDLRLAVKAIAAAYEALTPRAADPLNPLTCY
>NZ_CP046172.1|WP_167478430.1|9427121_9427466_+|hypothetical-protein
MEALAALLLIALFIYLTRPLRGTGYRLERYRPDPAGLSYYEEQRRYSELVAIYGRNDASDTETLPGSARPVADTSAETGAAKVNPTWPRRPTSDTPARRTTSACPRRPNPLAAG

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Crispr_ID: NZ_CP046172_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046172_18

9741525-9741622

Orphan

Consensus_repeat	Method
CGACTGCGGCACAGAACCACCCGGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046172_18

>merge|NZ_CP046172|18|9741525-9741622|CRISPRCasFinder
CGACTGCGGCACAGAACCACCCGGCGAGCCGGACGACGACGCGTCAGCACCCGACGGTTGGCCCGCTGAACCCGACTGCGGCACAGAACCACCCGGCG

>NZ_CP046172|18|18|9741525-9741622|CRISPRCasFinder
CGACTGCGGCACAGAACCACCCGGCG	AGCCGGACGACGACGCGTCAGCACCCGACGGTTGGCCCGCTGAACC
CGACTGCGGCACAGAACCACCCGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046172.1\|WP_167478678.1\|9732397_9732700_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167479929.1\|9735981_9736707_+\|phosphohydrolase	unknown	unknown	gnl\|CDD\|188314
NZ_CP046172.1\|WP_167478685.1\|9745364_9746177_+\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NZ_CP046172.1\|WP_167478687.1\|9752218_9753739_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167479930.1\|9739562_9741047_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167478683.1\|9743013_9743796_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|236210
NZ_CP046172.1\|WP_167478682.1\|9737449_9739282_-\|phosphoenolpyruvate-carboxykinase-(GTP)	unknown	unknown	gnl\|CDD\|235256
NZ_CP046172.1\|WP_167478686.1\|9746155_9746899_+\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|376672
NZ_CP046172.1\|WP_167478679.1\|9732910_9734356_+\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143457
NZ_CP046172.1\|WP_167478680.1\|9734906_9735851_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|181818
NZ_CP046172.1\|WP_167478688.1\|9753946_9754585_+\|DUF4097-domain-containing-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167479932.1\|9755122_9756781_-\|DUF2339-domain-containing-protein	unknown	unknown	gnl\|CDD\|378390
NZ_CP046172.1\|WP_167478684.1\|9743969_9745316_+\|lipase	unknown	unknown	gnl\|CDD\|367570
NZ_CP046172.1\|WP_167478676.1\|9730265_9731432_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NZ_CP046172.1\|WP_167478677.1\|9731610_9732396_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NZ_CP046172.1\|WP_167479931.1\|9741822_9742932_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167478681.1\|9736764_9737295_-\|DinB-family-protein	unknown	unknown	gnl\|CDD\|368218
NZ_CP046172.1\|WP_167478690.1\|9758211_9759405_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197775
NZ_CP046172.1\|WP_167479928.1\|9734352_9734547_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167478689.1\|9757580_9758027_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP046172.1\|WP_167478682.1\|9737449_9739282_-\|phosphoenolpyruvate-carboxykinase-(GTP)	gnl\|CDD\|235256	PRK04210, PRK04210, phosphoenolpyruvate carboxykinase (GTP).	0
NZ_CP046172.1\|WP_167479929.1\|9735981_9736707_+\|phosphohydrolase	gnl\|CDD\|188314	TIGR03401, Uncharacterized_protein_YFL061W/YNL335W, HD domain protein, cyanamide hydratase family. Members of this protein family are known, so far, in the Ascomycota, a branch of the Fungi, and contain an HD domain (pfam01966), found typically in various metal-dependent phosphohydrolases. The only characterized member of this family, from the soil fungus Myrothecium verrucaria, is cyanamide hydratase (EC 4.2.1.69), a zinc-containing homohexamer that adds water to the fertilizer cyanamide (NCNH2), a nitrile compound, to produce urea (NH2-CO-NH2). Homologs are likely to be nitrile hydratases.	2.39576e-11
NZ_CP046172.1\|WP_167478685.1\|9745364_9746177_+\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	9.48422e-92
NZ_CP046172.1\|WP_167478690.1\|9758211_9759405_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	2.12613e-09
NZ_CP046172.1\|WP_167478683.1\|9743013_9743796_-\|SDR-family-oxidoreductase	gnl\|CDD\|236210	PRK08267, PRK08267, SDR family oxidoreductase.	1.41262e-124
NZ_CP046172.1\|WP_167478676.1\|9730265_9731432_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	3.56983e-55
NZ_CP046172.1\|WP_167478686.1\|9746155_9746899_+\|NYN-domain-containing-protein	gnl\|CDD\|376672	pfam01936, NYN, NYN domain. These domains are found in the eukaryotic proteins typified by the Nedd4-binding protein 1 and the bacterial YacP-like proteins (Nedd4-BP1, YacP nucleases; NYN domains). The NYN domain shares a common protein fold with two other previously characterized groups of nucleases, namely the PIN (PilT N-terminal) and FLAP/5' --> 3' exonuclease superfamilies. These proteins share a common set of 4 acidic conserved residues that are predicted to constitute their active site. Based on the conservation of the acidic residues and structural elements Aravind and colleagues suggest that PIN and NYN domains are likely to bind only a single metal ion, unlike the FLAP/5' --> 3' exonuclease superfamily, which binds two metal ions. Based on conserved gene neighborhoods Aravind and colleagues infer that the bacterial members are likely to be components of the processome/degradsome that process tRNAs or ribosomal RNAs.	0.000164364
NZ_CP046172.1\|WP_167478679.1\|9732910_9734356_+\|aldehyde-dehydrogenase	gnl\|CDD\|143457	cd07139, ALDH_AldA-Rv0768, Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like. The Mycobacterium tuberculosis NAD+-dependent, aldehyde dehydrogenase PDB structure, 3B4W, and the Mycobacterium tuberculosis H37Rv aldehyde dehydrogenase AldA (locus Rv0768) sequence, as well as the Rhodococcus rhodochrous ALDH involved in haloalkane catabolism, and other similar sequences, are included in this CD.	0
NZ_CP046172.1\|WP_167478680.1\|9734906_9735851_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|181818	PRK09393, ftrA, transcriptional activator FtrA; Provisional.	9.92844e-107
NZ_CP046172.1\|WP_167479932.1\|9755122_9756781_-\|DUF2339-domain-containing-protein	gnl\|CDD\|378390	pfam10101, DUF2339, Predicted membrane protein (DUF2339). This domain, found in various hypothetical bacterial proteins, has no known function.	5.30162e-09
NZ_CP046172.1\|WP_167478677.1\|9731610_9732396_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	3.20674e-19
NZ_CP046172.1\|WP_167478684.1\|9743969_9745316_+\|lipase	gnl\|CDD\|367570	pfam03583, LIP, Secretory lipase. These lipases are expressed and secreted during the infection cycle of these pathogens. In particular, C. albicans has a large number of different lipases, possibly reflecting broad lipolytic activity, which may contribute to the persistence and virulence of C. albicans in human tissue.	2.88482e-64
NZ_CP046172.1\|WP_167478681.1\|9736764_9737295_-\|DinB-family-protein	gnl\|CDD\|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	8.97408e-45

>NZ_CP046172.1|WP_167479930.1|9739562_9741047_-|hypothetical-protein
MSPEIEAVVSRWNPQGVALLKAVRRAGDASAVTLIGPDDANTTLLRTELARYEPRIALGDPVADAHAAVESTSPSGQAPAAVALVLLDAGTTLGGDTLRMLQRLRQDGTRILLAMNGIHAHQDWRSVRELNLGLLAGAGLGDIDVLPVSGRLAVAARASGDPGLMDRAGLGALHAELTAAAMGADAAGADRTAAITVRVLAETRRRIEDQIEQLRSGGEIARLREERATLLAGRDGGRATSLSTLRGQLHLARVDLLTDVGGRVRALHTAARGELDRLRPNRLGDYPDRLQQAVTELTGQLDAEIDQRLAELAHRVDELSPAEPAPYRRRDPAPRVGPDPDPRHRGVEDHLMIALGASAGVGLGRLLVSPLALVPALDVASVPFTLLLGAGAAAWVVRARGQVADRNHVRQWVSEALVNVKAQLEQRVTTALVETETAFSDRVVRASATAMVETDRRIAELEARIRRMAAEQPGQLAACQRDIECLDRWVPPSD
>NZ_CP046172.1|WP_167478682.1|9737449_9739282_-|phosphoenolpyruvate-carboxykinase-(GTP)
MTSATIPGLRGSDGKAPTEHSELLAWVQEVAELTQPDRVVWADGSDEEWDRLTEQLVAAGTFKKLDEKKKPNSFLALSDPSDVARVESRTYICSKTEADAGPTNNWVDPAEMRATMTELYRGSMKGRTMYVVPFCMGPLGAEDPKLGVEITDSEYVVVSMRVMTRMGAAAMEKLGTDRPFVKALHSVGAPLADGQADVPWPCNDTKYITHFPEDREIWSYGSGYGGNALLGKKCYSLRIASAMAHDEGWLAEHMLILKLISPENKAYYIAAAFPSACGKTNLAMIQPTVPGWRAETLGDDIAWMRFGKDGRLYAVNPEYGFFGVAPGTNRSSNPNAMATMDAGNTVYTNVALTDNNDVWWEGLEGEPDHLIDWKGNDWYFRETETLAAHPNSRYCTPMAQCPILAPEWEDPQGVPISAILFGGRRKTTVPLVTESFDWQHGVFMGATLSSEQTAAAEGKVGTVRRDPMAMLPFMGYHVGDYLGHWINIGKNADAAKLPKIFYVNWFRRGADGRFLWPGFGENSRVLEWIVDRIEGRAEAVETAIGNVPTATHLDLDGLKVETADVDEALAVNADEWRKEIPLIEEWFEFIGDKLPSGIRDEFEALKQRLG
>NZ_CP046172.1|WP_167478681.1|9736764_9737295_-|DinB-family-protein
MGEAEAIRAESVIDAPPKVQFETFIDQHRAYLNACLDGLTEEQARRRLVSSKTTLLGLVKHVTFAEQVWFDEAITGRTRAEIGIPETPDETFVLTEQDTIESVRAAHRAACAASRRMTANLGIDDIVSGNRRGPLPLRWVYMHVLRELAQHCGHADILREQILHPIESVSAPDDLG
>NZ_CP046172.1|WP_167479929.1|9735981_9736707_+|phosphohydrolase
MDWDWAIDTGGNLSGSQRRQQLGLFLAAAPQLIAGRVKLAMGRRGNGRCDLGDVPDSKLAKAAEIEARECLTPHVLEHSYRTYFFGRALYEFVGAPYDDELAYVASLLHDLKLEHPTPGRCFAVTGAERAVDFVKAHGATPEQAATIGAGIAAHLTVGVAQQLGDLGFVSAGAGTDVFGTGLAEMSPDWVAALLRQHPRHDFKRHMRAAVAAESAAVPGGRTKWLSTVGFQQLIQLAPFAE
>NZ_CP046172.1|WP_167478680.1|9734906_9735851_-|helix-turn-helix-domain-containing-protein
MRKVVALALDGLITYDLTCAVQAFRYCPGKDGAPLGFRFDTCGVRPGPVASPDGFELHVEHGLAALADADIVIVPGRAPGPVPDAALEALRAAAARGATMVSICIGAYVLAEAGLLDGRPATTHWAFCDDFAARYPAVRLDPGALYVDDGDVLTSAGLSAGWDLCLHIVRKELGAAIAAELARWNVRPPHREGGQAQYLPNPRQRNDIHDSLAPTLAWAAADPAVELAVPDLARHALMSERTFIRKFKAEVGTTPRRWLDAQRAARARELLETTDLPVEVVAAQAGFGSVTALRAHLRAATGATPAGYRRSRRR
>NZ_CP046172.1|WP_167479928.1|9734352_9734547_-|hypothetical-protein
MPFRVPAVPLVAGLELATASTPLRRAAGRLQAVLPPGWRVEVVDAPERPGRERESILRVVMPEN
>NZ_CP046172.1|WP_167478679.1|9732910_9734356_+|aldehyde-dehydrogenase
MHYDSLFIGGRWTAPTSSERLQVVSPATVEPVGSVPVVERADVDAAVAAARRAFDSGPWPSTPPEERAEVLSRAARLIEQRSADLLGALTAEMGATATIGLTLNQIPAVAALDTYAGLAKSFPWKETRTGLFGTSRVSREPLGVVAAITAWNVPLFLAANKLAPALLAGCTVVLKPAPLTPLSANIVADIFTEAGLPEGVLSVLPAEAEVAEYLVRHPGVDKLTFTGSTAVGRRIGAIATEQLKRVSLELGGKSAAILLPDMDLAASIPVLAFSGLMNSGQGCVAQTRILAPRSRYDEILDALVEYVKTMRVGDPSDPNVQLGPLISERQRDRVEGYIAKGKADGARLVLGGGRPAGIDRGWFVEPTIFADVDNGSTIAQEEIFGPVLSVIPYETEDEAVAIANDSVYGLAGSVWTQDIEHGAEIAARVRTGTYAINWYAFDPSSPFGGYKSSGLGRENGPEGLDAFCEQKSLLMPMGWTG
>NZ_CP046172.1|WP_167478678.1|9732397_9732700_-|hypothetical-protein
MAVQVVGRSLMTSDQTEHQAKSVGGGGWVVSFLPGRTLTIEQATAAMQAAEAVAVVGMLADQVGLTTLETVGLAIQESPWGEPVREICGRRHWRRGRLEQ
>NZ_CP046172.1|WP_167478677.1|9731610_9732396_+|class-I-SAM-dependent-methyltransferase
MLRAKTSSPDRAVPSFARRATLRRSLRLLASFKFEQTDPAHFYGGIATDSAELIADYYADLTGRTLCGATVLDVGGGPGYFADEFGAAGARYIPVEPDPSELHAAGLSVSGAVRGSGMALPFRDNAVDICFSSNVAEHVPQPWLMAEEMVRVTRPGGLIVLSYTVWLGPFGGHETGPWHYLGGEYAARRYRRKYGREPKNRFGESLFAVRASDGLRWAATTSAEVLAVFPRYHPRWAWWLVRMPLLREFLVSNLVVVATKV
>NZ_CP046172.1|WP_167478676.1|9730265_9731432_-|glycosyltransferase-family-4-protein
MREVLLLCWRDTGHPQGGGSERYLEQVGARLSARGVKVTLRTARYPGAPRRERIDGIEISRGGGRYTVYPRALAAILFGRLGLGPLRGLRPDAVIDTQNGIPFFATAATGAPSVVLVHHGHREQWPVAGRLVGRIGWWIESRLSPRVHRRNQYLTVSLPSAEELATLGVDRARIAVVRNGAEPVPADAPTGAAETRSARPRVVVLSRLVPHKQIEDALAAVARLRTRIPDLHLDVVGGGWWADNLAADAAALGIADAVTFHGHVDERRKHELLSRAWVHVLPSRKEGWGLAVIEAAQHGVPTIGYRASRGLTDSVVDGVTGILVDDIAQLTDAVGELLDDPATRTVMGEKARARAREFSWEQTGNGVYEVLAAAARGEYRSGLIPPAP
>NZ_CP046172.1|WP_167479931.1|9741822_9742932_-|hypothetical-protein
MRERGVPGREHDQLEQLLNDLLVAGGADTQLGYYVGAAVNEWRKPPRIQVTGRAHSGRTTVLQALALMSAVETEPVDAPGNPDPVLDADIIVYVLAGTPTAADRRVLGELPADRAIVAVNKADAIGSRWADAVAAADQIGRELGVPALPVVASLAVRTRAGAITDADLRTLRRHAANTDPALTLSPDLFTARTAGPDVAERVELLNRWDLYGVACALTALRHDPAITPQALLQLMHAASGIDALHRLLHRRYEQVQALRGGDLLDELTRLAARAVPVDGSRGRALLEDYLSGDEASWLGLCAGLACPAVAHLAAGYPRPAPDDADDAMVRAARWRVIVSGDMPPAACRAALRVHNGYVRLWDRLTSAGL
>NZ_CP046172.1|WP_167478683.1|9743013_9743796_-|SDR-family-oxidoreductase
MTRPSMFITGAAAGIGRATALLFAAQGYRVGAYDIDEVGLTRLAAEITASGGSIRTGVLDVTNATHWAERLADFHADVGRLDILVNNAGILRAGPFEKLDLAGHQAIIDINLGGVVIGTHTAFPYLRDTPGAQVVNLCSASALYGQPELASYGATKSAVKSLTEALDLEWERHDIRVIAVWPLFVGTGMVEGVDTGTTRSLGIRLTADDVANGIWSATSKRGRLPRVHYEIGTQAKVLATVAKYSPNWAVRTVNKYFSGS
>NZ_CP046172.1|WP_167478684.1|9743969_9745316_+|lipase
MTLDVVDAEPEPIAQPATGKPLLPSKDPFHRPPKGFASKPAGTILRARRIELALFGIVPQQVSAWQLLYRSCDLHGTPEAAITTVLLPLDADPREDRPLLAFQTAMDAVTERCAPSYALRLGAHALGSITQLEWLLVANALRRGWAVSIADHEGPHGNFGAPREPGYRALDGIRAALRFEPLGLHSGTRVAVWGYSGGGMASSWAVEMAPTYAPEIDIAGAVLGAPVGDPGQVFMRLNGSHFAGLPAIVIAALRRLYPALGALIEDELTGEGLRMVARAESTNPILAVLTLTGKKFDDYLGRPLTEVLAAPAFLAMFDELRLGNSVPDCPLLVVQPVHDQVIHMDGIDGQVDRYRRGGAIVSYVRDRLSEHFSLLPLATPMSLDWLNERLAGQPVSDEETRTVWSVVASPAGVRGLWEMATTAVLCALGRPLRQESAPVARISRVRAA
>NZ_CP046172.1|WP_167478685.1|9745364_9746177_+|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MDAVNDAANHTAESVPGQPSTAAAPTAAARRQGSGSRLYPRVTSFRSRRGALTATQQQSWDRMWPSIGREVADEPLDAAAWFGREAPLVIEIGCGTGTATAAMAQAEPHLNLIGIEVYQPGLAQLVQRVERERIPNIRLLRGDAVDVLENMIAEQSLTGVRVFFPDPWPKARHHKRRLLQPATVKLIASRLRPGGVLHVATDHADYAEQILEVGSAEPQLIGLNETTGGVSAEHRDTAPIGFERPVTKFEGKAHRAGSAITELIWGKIDI
>NZ_CP046172.1|WP_167478686.1|9746155_9746899_+|NYN-domain-containing-protein
MGEDRHMSVSEMAHEVVDVAGEVHGTVPEGMNPTPDVRRVLLVWDAPNLDMGLGAILGGRPTAAYRPRFDALGRWLLARTAELSVGSPTRVEPEATVFTNIAPGTADVVRPWVEALRNVGYAVFAKPKIDEDSDVDADMLAHIELRRRGAGLAGIMVASADGQAFREPLEAIAAAGIPVQVLGFREHASWAVTSDTLEFIDLEDIPGVFREPLPRVSLDSLPDEGAWLQPFRPLSALLTSRPAQGVA
>NZ_CP046172.1|WP_167478687.1|9752218_9753739_-|hypothetical-protein
MLESSWTDTAGAVAVVSEAAEFDWTWARGDIDRFCSRMGWEEPREWWDDRAIWWARTDIEIEDAVATFRLVGDRLISVTVPVSENGRGAGEFGADAVSGTVAALVEEFDEPTAEWISARYGPSWDFGSVVAGVVHGAAIDVVLVSPMEQNHWIEYRDWREDIRTRAAERLGDKEICFTDAVSGLLRAEFGAWSRAEIDATLAGLGLKSDDPSGKRSDITVEPADDEQRAAFGYGETAYLELAHGCSDILLDNVFQTIFATCRELLGVPDLIGGGADLFVIWNGADTTVELTRRASRYGYGAMGVAVRLSPTDPTQNWLAHEAAALEGDDYDDYDSYDECHYDYYNPDPHQRWHFRPDPARPVRPHFGRATDPTWAVNKWDHFADNLRLLFDSFADELRFVPDIDEIGWAIGIYDELAPIAHGWFSATGCGVHTYDAGGLRTWTYPAERLSGRLVANKAITAIRAPGTMPKELWCEAWLPGRPHGFTAIRFGTRGDRPAARDLPLHW
>NZ_CP046172.1|WP_167478688.1|9753946_9754585_+|DUF4097-domain-containing-protein
MYKFQTSDPIAVAVDVLSGNVTVIASDRTDTVVEVRPADESKKSDVRAAEQAKVDFAAGKLTVQTPKDWRTYSPFGGNPTIEVVIEVPAGSGFQGSTSMGRLLGSGELGECELEVAAGDIIVERPLGSVTAKTSKGDIRIGEASRGVLRLETSTGELEIGISAGSAAQLEVNAHGSVQNLMQPVDPSKGNGDTVQVYARNSFGNVIIRHATA
>NZ_CP046172.1|WP_167479932.1|9755122_9756781_-|DUF2339-domain-containing-protein
MAGAPVGLWGVQRPMPPVRREPRTPWWQRDGVISRLLAVAGVAVTLIGVVMLLVLAAQAGFFGPVLRVVAGAVFSVGLLAVGMRVFGRAGGRTGGIALAATGIAGAYLEVVAVTAIYHWVPAELGLVLALMVAAGGVALAMRWGAQALAVLVVSGAALLSPALTGELVLLAFLIVLQGAFLPVQLRRDWPLLHIARTLPVALGVLFYMAGTAFETPGRDRLYWLLAAAVAVAAIGLIGALLAVRTRPRDFTATAAFALSTLPLLAAPALFDAATAAIVSGSFAAVLLALAAASFVTKLAASLRIPAHTTVVAAIAGSFALFEACLGVTRVQTLPIALFLVALGYFAIAGQLHAKVPAAIGIAFAALGAMLFVGQASPATLASQHLASENLGISTALAAVLALAVAATALWSLRRLPGVADPGTESGLWITASLTGLYAVTAATVSLGVASATRDGFRIGHTAATILWMIAATAALLFGLRMLAHSAALAKTALVSGLLVTAAALAKLFLFDLATLDGLLRAAAFLVVGVLLLLAGTRYARAFADANNDSARN
>NZ_CP046172.1|WP_167478689.1|9757580_9758027_-|hypothetical-protein
MFESCHSPHDIAHLLRHRYGLPVQVIAGRPMITTGSILGAMVMPAELGQRVLAAVEPGYSTPVVADPGERTWTFLVDPVLSVDVEVRRDLAEHHVTVVPSGRNVMLPATDSPLGWHWAGEPESGVLRLPPRAAVIAAVHQTTERQLAS
>NZ_CP046172.1|WP_167478690.1|9758211_9759405_+|helix-turn-helix-transcriptional-regulator
MDDSSIGVRIRQFRGKALTQRQLADQAGVSVDLVRKLEQGGRQTASIASLQKIARALDVDIADLIGRRHGIPSSNPDAGIVAIRRALTPVDDLLGETREETAVGHAEGSRAVEYAWGAYWAGRYELLTTILPQGLTQLRATVHAAHNGAVAAANELLARMYWVTGCTLVHLGQTDPAFMAIRHALTAAAKGDDPLLLATIRGSVAWQLLVQGRYEESHGVALTAAAALEPDGDATPAHLSAYGSLVLQGATAAGRAQRVPEALSLIETASAIALRIGVDRRDYETYFGPSQVIMQTVDVNVCAERYPEALSAAKAMPPTGGGLPQAARARHLTDTAVALTRTGQHERAFSALLDAERVGGADWIKYQTLPRHIVAELIDQDRRAPLRAFATRLGMKV

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Crispr_ID: NZ_CP046172_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046172_19

10002648-10002841

Orphan

Consensus_repeat	Method
CGCCGCCCGCTGATCGCCGCTGCCCGCTGGTC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP046172_19

>merge|NZ_CP046172|19|10002648-10002841|CRISPRCasFinder
CCCCGTCCGCCGCACGCCGCTGCCAACTGACCGCCCGCCACCCCGCCACCGCGTGTGGCTCCTGACCGCCCGCCGCCCTCCGGCCATAACTCGCCGCTCTCCCCGCCACCCGCCCGCTGCCCGCTGATCGCCGCTGCCCGCTGATCGCCGCCCGCTGATCGCCGCTGCCCGCTGGTCGCCCCCGCCCGCTGGTC

>NZ_CP046172|19|19|10002648-10002841|CRISPRCasFinder
CCCCGTCCGCCGCACGCCGCTGCCAACTGACC	GCCCGCCACCCCGCCACCGCGTGTGGCTCCTGACCGCCCGCCGCCCTCCGGCCATAACTCGCCGCTCTCCCCGCC
ACCCGCCCGCTGCCCGCTGATCGCCGCTGCCC	GCTGATCGCCGCCCGCTGATCGC
CGCTGCCCGCTGGTCGCCCCCGCCCGCTGGTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046172.1\|WP_167478867.1\|9995015_9995819_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167478877.1\|10012751_10013198_-\|ribonuclease-P-protein-component	unknown	unknown	gnl\|CDD\|235126
NZ_CP046172.1\|WP_167478872.1\|10000900_10001908_-\|ParA-family-protein	unknown	unknown	gnl\|CDD\|379293
NZ_CP046172.1\|WP_167478873.1\|10008304_10008880_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|179433
NZ_CP046172.1\|WP_167479975.1\|10010592_10011090_-\|protein-jag	unknown	unknown	gnl\|CDD\|224760
NZ_CP046172.1\|WP_058854877.1\|10013219_10013363_-\|50S-ribosomal-protein-L34	unknown	unknown	gnl\|CDD\|366117
NZ_CP046172.1\|WP_167472021.1\|10003766_10004582_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|224401
NZ_CP046172.1\|WP_167479971.1\|9987092_9989606_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046172.1\|WP_167478875.1\|10011230_10012349_-\|membrane-protein-insertase-YidC	unknown	unknown	gnl\|CDD\|179580
NZ_CP046172.1\|WP_167478869.1\|9996910_9997234_+\|thioredoxin	unknown	unknown	gnl\|CDD\|200072
NZ_CP046172.1\|WP_167478876.1\|10012353_10012755_-\|membrane-protein-insertion-efficiency-factor-YidD	unknown	unknown	gnl\|CDD\|376620
NZ_CP046172.1\|WP_167479974.1\|9998747_9999479_-\|GNAT-family-N-acetyltransferase	unknown	unknown	unknown
NZ_CP046172.1\|WP_167478870.1\|9997472_9998660_+\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|223929
NZ_CP046172.1\|WP_167472022.1\|10004578_10006126_-\|IS21-family-transposase	unknown	unknown	gnl\|CDD\|226950
NZ_CP046172.1\|WP_167479972.1\|9990268_9994006_+\|peptidoglycan-biosynthesis-protein-MviN	unknown	unknown	gnl\|CDD\|240528
NZ_CP046172.1\|WP_167479973.1\|9994345_9994906_+\|RNA-polymerase-sigma-factor-SigM	unknown	unknown	gnl\|CDD\|236604
NZ_CP046172.1\|WP_167478874.1\|10009717_10010485_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	unknown	unknown	gnl\|CDD\|234637
NZ_CP046172.1\|WP_167478868.1\|9995895_9996879_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NZ_CP046172.1\|WP_167478871.1\|9999809_10000847_-\|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl\|CDD\|275105

Protein	Function_ID	Function_description	E-value
NZ_CP046172.1\|WP_167478877.1\|10012751_10013198_-\|ribonuclease-P-protein-component	gnl\|CDD\|235126	PRK03459, rnpA, ribonuclease P; Reviewed.	5.46066e-45
NZ_CP046172.1\|WP_167478873.1\|10008304_10008880_+\|AAA-family-ATPase	gnl\|CDD\|179433	PRK02496, adk, adenylate kinase; Provisional.	1.65907e-25
NZ_CP046172.1\|WP_167479975.1\|10010592_10011090_-\|protein-jag	gnl\|CDD\|224760	COG1847, Jag, Predicted RNA-binding protein [General function prediction only].	2.78717e-54
NZ_CP046172.1\|WP_058854877.1\|10013219_10013363_-\|50S-ribosomal-protein-L34	gnl\|CDD\|366117	pfam00468, Ribosomal_L34, Ribosomal protein L34.	5.53987e-08
NZ_CP046172.1\|WP_167472021.1\|10003766_10004582_-\|ATP-binding-protein	gnl\|CDD\|224401	COG1484, DnaC, DNA replication protein [DNA replication, recombination, and repair].	2.78816e-34
NZ_CP046172.1\|WP_167478872.1\|10000900_10001908_-\|ParA-family-protein	gnl\|CDD\|379293	pfam13614, AAA_31, AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	4.69121e-85
NZ_CP046172.1\|WP_167478875.1\|10011230_10012349_-\|membrane-protein-insertase-YidC	gnl\|CDD\|179580	PRK03449, PRK03449, putative inner membrane protein translocase component YidC; Provisional.	0
NZ_CP046172.1\|WP_167478869.1\|9996910_9997234_+\|thioredoxin	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	3.5126e-45
NZ_CP046172.1\|WP_167478876.1\|10012353_10012755_-\|membrane-protein-insertion-efficiency-factor-YidD	gnl\|CDD\|376620	pfam01809, Haemolytic, Haemolytic domain. This domain has haemolytic activity. It is found in short (73-103 amino acid) proteins and contains three conserved cysteine residues.	2.24753e-32
NZ_CP046172.1\|WP_167478870.1\|9997472_9998660_+\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|223929	COG0860, AmiC, N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane].	2.08451e-43
NZ_CP046172.1\|WP_167472022.1\|10004578_10006126_-\|IS21-family-transposase	gnl\|CDD\|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.04425e-12
NZ_CP046172.1\|WP_167479972.1\|9990268_9994006_+\|peptidoglycan-biosynthesis-protein-MviN	gnl\|CDD\|240528	cd13123, MATE_MurJ_like, MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	1.66495e-100
NZ_CP046172.1\|WP_167479973.1\|9994345_9994906_+\|RNA-polymerase-sigma-factor-SigM	gnl\|CDD\|236604	PRK09643, PRK09643, RNA polymerase sigma factor SigM; Reviewed.	3.57413e-89
NZ_CP046172.1\|WP_167478874.1\|10009717_10010485_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	gnl\|CDD\|234637	PRK00107, gidB, 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG.	6.18711e-64
NZ_CP046172.1\|WP_167478868.1\|9995895_9996879_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	6.10167e-156
NZ_CP046172.1\|WP_167478871.1\|9999809_10000847_-\|ParB/RepB/Spo0J-family-partition-protein	gnl\|CDD\|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	1.44043e-78

>NZ_CP046172.1|WP_167478872.1|10000900_10001908_-|ParA-family-protein
MSSGPANVSRETTSRVPGMLDSSNFDADAFGSTPFGHISPSETPIAAEAQRASQILHPGKVTVPKPHEQRIITIANQKGGVGKTTTAVNLAAALAHQGMTVLVIDLDPQGNASTALGIEHHSGVPSSYELLIGEVSVKDAIQQSPHSERLLCIPATIDLAGAEIELVSMVAREGRLKAAIQEANIAGYDIDYVMIDCPPSLGLLTVNALVAAKEVLIPIQCEYYALEGVGQLLRNIGLVQAHLNPELHVSTVILTMYDGRTKLADQVAEEVRGHFGDVVLRSVIPRSVKVSEAPGYGMTVLDYDPGSRGAMSYLDAGREMAARAMAQQSGAGGAA
>NZ_CP046172.1|WP_167478871.1|9999809_10000847_-|ParB/RepB/Spo0J-family-partition-protein
MSQAKSQAKKGGLGRGLGALIPTGPAGAPGAPGLSASAASVIGINPIGPQPATSYLHRVPDIDETAELAAGGAVYREIPADQIEPNPKQPRQYFEEEALKELVHSIREFGLMQPIVVRKIDGDADKYQLVMGERRWRACQVAGLTTIPAIVRETTDDSMLRDALLENIHRVQLNPLEEGAAYQQLLEEFDVTHEELAKRIGRSRSVVTNMIRLLNLPIAVQGRVATGILSAGHARALLGLNAGPAAQEEMAKRIVAEGLSVRTTEEAVRLANLEPEPEPRNADPAPRRKPIEMPRLQDVAERLSHSFDTRVIVSMGKRKGKIVVEFGSVGDLERIVSLMEQQLGS
>NZ_CP046172.1|WP_167479974.1|9998747_9999479_-|GNAT-family-N-acetyltransferase
MSTSVTALTLGGLDKLPGHARRCVFWEIDPAIAENCREFSDPVFEKEAWLSTVMLEWGSCGQVATVDGNPAGCALYAPPSAVPRAAVFPTSPVSPDAVLLTTLRAEFPHHEGDIPHRLIQAVVADLVRRGVRALEAFGIRRTPPATALTERAIGSMKLMERIDSVRDTLVSAGAATACSPETCMIDADFLEDFGFKVVAPHHRFPRLRLELNSDHGWKEDVERALDQLLAAASMTAPTRVGAR
>NZ_CP046172.1|WP_167478870.1|9997472_9998660_+|N-acetylmuramoyl-L-alanine-amidase
MHRLRHGDTGPAVAEVRSTLASLGFLHAHGTDHADAQYWKDTEASFDHHLDSAVRAFQQHRGLLVDGVVGPATYRALKEASYRLGARTLIYQLSAPLYGDDVATLQRRLQDLGYYVHRIDGYFGPHTHDALSTFQREIGLSADGICGPDTLRSLELLGARVTGGNPHRIAEEEVVHRAGPQLTGKRIVIDPGLGGPDKGFAVPTEFGDVYESEILWDLASRLEGRMAATGMETFLSRPWGANPTDAERAETSNAFDADLMISLRCATNPSPSANGVASFHFGNSHGSTSMIGQVLAGFIQREVVARTSLQDCRTHPRTWDLLRLTKMPTVQVDIGYMTNEYDASVLTNPRMRDVIAEAILISVKRLYLLGQDDQPTGTYTFAELLAEELAAADRM
>NZ_CP046172.1|WP_167478869.1|9996910_9997234_+|thioredoxin
MSKTVTVTDASFADDVLLNEKPVLVDFWADWCGPCKMVAPVLAEIADAYADKLVVAKLDVDANPNTARDYKILSLPTMMLFRGGKPVKQIVGAKGKAALLRELEGVI
>NZ_CP046172.1|WP_167478868.1|9995895_9996879_+|thioredoxin-disulfide-reductase
MSNVRDLIIVGSGPAGYTAAVYAARAELQPLVFEGTQFGGALMTTTEVENFPGFRTGIMGPDLMEEMREQAKRFGAEIRTEDVEAIDLSGPIKSVTVGGQTYQAYSIILAMGSAARYLNVPGEQELLGHGVSACATCDGFFFKGQDIVVVGGGDSAMEEATFLTKFASSVTIVHRREEFRASRIMLERAKANEKIKFVLNTEVVSVNGESSVTSLTLRDTKTGETSELAATGLFVAIGHDPRSELVRGQIDIDENGYVQVQDPSTATKIPGVFAAGDLVDHTYRQAITAAGTGCRAAIDAERWLAEQGDITANTLDHAGQAVAVSAN
>NZ_CP046172.1|WP_167478867.1|9995015_9995819_+|hypothetical-protein
MATRSVPQPPFSPELLADLHADNVAPELRAELLPAVQRDPEAMRFLNSLDAVGAELRALGRDERIIHPMPDDVLARLTRFVDDLDISEGPTERVATVHRLPVAAPPESTAGPTDSEPMGFAEPIDLTARRNRRFRWLAAAAAAVAVVGAATFAITMTTDRSVPPTAMPSATATGSNNADLTPAAALSALGRFDVTGPLSGPNALNRCAAAAGYEHRTPLGAVNWTYEGKDAVLVLLTGPVAPKITALIVGTGCTAGDPQYLYATDIG
>NZ_CP046172.1|WP_167479973.1|9994345_9994906_+|RNA-polymerase-sigma-factor-SigM
MLDELTDVELLKAHVGGQRHAFAELLRRHNDHLWQTALRTSYTREDAADSLQDALLSAHRTAASFRAEAEVRSWLHAIVVNACLDRIRRNKTRYAISLSPETMPEPSDDRDEFAELEMSLVVDRALFSLPPDQRTALVAIDLEGYSVSEAAAMLGVPEGTIKSRCARARQRLQERLEFLRDPGNRK
>NZ_CP046172.1|WP_167479972.1|9990268_9994006_+|peptidoglycan-biosynthesis-protein-MviN
MVERADSPADHTVTGELSQVKAPEKPQNANARLVRDSGSIAVATLISRITGFVKQLLLLTVLGPAIASAFTSANLIPTMITELVLGAVLTAMVVPTLVRAEQEDEDGGVAFVRRLVTIAFSILFVATVLAMAAAPVLASKILLSAEGQVNTQLTTALTFLLLPAILFYGMSALLMAILNTRQVFRPGAWAPVLNNVVVLGVLALYALTPGEITLDPVRMSDPKLLVLGCGITIGVAVQALSMLPAIRRNGIDLRPLWGIDQRLKQFGRMGGAIILYVLISQIGLIVANHISSSADEAGPAIYANAWALLQVPYGVLGVTLLTAIMPRLSRNAAADDTPAVVDDLSVATRLTMISLVPVVTFMTVAGPQLGEALFGYARFAHKAQELGHAVSWSAFALIPYALVLIHLRVFYARGQAWTPTWIVLGITTVKILLSALAPMIASDGKQVVVILGFANGLGYATGAIIGGYLLHRSLGDLRMVNVGRTVTRVVLASLAGAAVMYIFDRVVGLDRLHGGPGALIRVTLSAIVMFGVAFGLMRLAGIPEIVAITVAISRRLGFTPPAPELDLESPVEDEYATTVLRRPDYYAYPAFDPVMDTQTMVLPVIRPDTVDNTRVGQFPYPVRQRSTSGEFTGTSTHQGEGGTRVSDDAVGGVPAADSSATTAGGLSTDVPPVAGDASDPASVQEPDTGPPGMPDAPEEEQPEEHDPVYDTGMHPVASQLPPMGGGEPAGSRRTPRGPKLIPGASVAGGRYRLLAGHGGARGLKFWQALDIKLDREVALTFVDADQKATENAGHDGPQAILSRTLRLGRINSPGLARVLDVVRGSSGGIVVAEWTPGRSLREMAETVPSPIGAARAIRALASAAELAHRGGGSLSIDHPDRVRISASGDAVLAFPGTLSDSDAQSDVRGLGAMLYALITARWPIRTGGMTGTAATVGGLRLADFGPDGTPIEPRQIRPEVPFEISAVAVRSLESNKGVRTAATVQHVLEQASVVDQKTDFIPVLRLGQRQGTRESDDSLADPELLAAERERSQRMMWIMVGLGVLAALVVGIVIWWMVSVFAPGASDAPLNEQRNIGLTTASAPPPAPPVSGPSPTVASGVPVPITSVSVFSPEGTPDNPGGVAAVLDSNPSTTWRTDQYFQQFPALKKGVGIMATLPSPAKLTTVAITSPSPGTQVEIRTSPTESPTLDQTQLIGSTRLNDGVTEIPVRTDQAARYVLVWITGLANNGGQFQSAIAEIRFDAAP
>NZ_CP046172.1|WP_167479971.1|9987092_9989606_+|hypothetical-protein
MLLRLVTALLAVLGSVTLAGPAGAQPSSTTNAPTAPEFLKLTLDSVSPTAVTANSDPLLTVSGTVTNIGNRVVKDIIIRLQRGAAISTPANLRATLRYDQVNFDIPAPWEDISNELSPGQRQQFTLSVPLRGKPNQSLEITKPGVYPLLLNVNGQPDFGLPARLDDARFLLPVLGLPPTPDSSDPGPVLPPTDAPIATTMIWPLADRPRMVGGQLGTVDRHVELTDDELAASFGKGGRLDQLLGALESVVGSNTGRDRPAVANAICIAIDPDLVRTAQAMIKGYRVLASPSDPGGPTRPGTGADAAQAWLDRLRALAESMCTIALPFAQVDPSALAAVNDPDLSAEALNAPADIVDEALGVRSLRGVSLPDSGSIDTGAGMLLRGRGFGTTVLADSAVTAVGDPSTKDTSASAGSGHGSGTASPAASQSVVETGTPDMVRLPDITGPAAHPDTPATPPADPALRAATFDIWSATALAAIGSNPPTPSFTPAKVRYDVAADSRAARLQDALGAVSWAALNPQPNHPRTLLLMPPQQWGANRDEAITLLRHLDLMIHGNLATARPFTELLATPPDPQPYELDYLHRAQQDAVPGGFVLPVRDQAARITDLQRALLDVPEAKPTPHDYLTPLRDDLIRALTLSDRRTGDTAQPDTFAQRRIAQTTRALDDLYGGVTVLPPGGVYTLATEQSPLLLVVRNKLPVTVRVKFKITAPPETKITDLPEQQLPPNSTRSFQIPTEVTYSTSLRIPISLTTPDGIALGAPTEVSVRSNAYGQAFAIITACAGILLFLLVGRRLWRRFRGQPDPADEGVDPSTQRRVYRYWRARNRVLQQEQEHQEV
>NZ_CP046172.1|WP_167472021.1|10003766_10004582_-|ATP-binding-protein
MSATRRPAADPAVKPIEITPELKSLMRRLKLGQLLDTLPERLALARSNRLPHHDFLEMLFADEVARRDRQSEQRRAKTAHLDPQMHLAAWDDSTAVTFDRELWAELTSMRFLADAYNVLIMGPVGVGKTFLANALGHIAVRRHHTVHTERADKLFKRLRGARLDSSYEDEMRKLHRVDLLIIDDLALHRLEAPETNDFYELIVERHRKASTVITSNREPPEILTMMADPLLAQSAMDRLQSAAYELVVEGESYRQRQKPRRGKPADPAHSD
>NZ_CP046172.1|WP_167472022.1|10004578_10006126_-|IS21-family-transposase
MSYREVSVIEIREMLRLWLQGRGLREVARLSGTDRKTVRRYVERAQSCGVDRDEGVEQLTDELLAAVIAGVRRSRPNGKSDVWETLAGQSEQIKQWLDQGLTLTKIHILLARRGVVVSYRTLNRYATTELGFGKRRTTVRVADCEPGAEVQVDFGRLGLLTDVEGRRRVVKGLIFTAVYSRHMFVFPTYRETLNDVIAGFEAAWVFFDGVFAVAIPDNMKAIVDRANATDPRLNDSFREYAESRGFVVDPARIRSPQDKPRVERCVPYARSNFFAGEQFRDLADCRERAQRWCRETAGMRIHGTTRLRPAEVFTTDEHPKLKPLPDTAFDIPTWVNPKVAPDRHVQICQALYSIPGDLVGQRLSARVDSQTVKLYFRGELIKVHPRVGAGRRQTDPADLPSELTAYAMRDLNTLQRKAFDHGAHVGSYAAAVLEHPLPWTKMRQVYRLLGLVRRHGADAVDDACRRALDAEVVDVGVIDRMLTRATTGQQLTLLPPPAPSRFVRSTTDFAVRRPS
>NZ_CP046172.1|WP_167478873.1|10008304_10008880_+|AAA-family-ATPase
MLKVVFIGGPGTLVHAHAESFAEAAQLAVLNPGDVMRTHLREQSPFGLRLDQYIDADELVPSELVLEMMLESLASVKGGWVLANFPRTVTQAESLARHGHAPTAVIELSVTDEQVRGRLRERDERLGQCTEHDSAVMRRLVQHRELAAYYQFKGNLHSVSGQGGSPGFGDYEDVEERLKPVHRHLLAKGHG
>NZ_CP046172.1|WP_167478874.1|10009717_10010485_-|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG
MFHVERDLGGTALPAELEPPDTAATVFGDRLDLARRYCAALATAGVERGLIGPREVPRLWDRHILNCAVIGELIGEGAAVVDIGSGAGLPGIPLAIARPDLRITLVEPLLRRTVFLSEFIDAAGLDVTVVRGRAEQSGVLKEAGGADVVTSRAVAPLAKLAQWSLPLLRDHGRMLALKGVSAAEELARDSDALIRAGAGNPAVLECGAGVVSTPTLVISAERLTRAERAPLRRAERAKSRAGEKGRTRRVVRRAE
>NZ_CP046172.1|WP_167479975.1|10010592_10011090_-|protein-jag
MAGAEPDVVNDAEEALIEEGEIAGDYLEQLLDVLDFDGDIDLDVEGDRAVVSIDGGKDLSKLVGRNGEVLDALQELTRLAVQQATGVRSRLMLDVAGWRAKRRSELSALGTATAKRVLESGAPESLAPMTPFERKIVHDAVAAIDGVSSESEGVEPNRHVVVVRS
>NZ_CP046172.1|WP_167478875.1|10011230_10012349_-|membrane-protein-insertase-YidC
MLDIIYYAVSAILWFWHRVFAAVPGLGKDSGIAWALAVVFLVFTLRLVLYKPFVKQVRTTKQMQELQPQIKELQKKYKNDRQKMATEMQKLQKENGFNPLMGCLPILAQVPVFLGLFHVLRSFNRTGHGLGQLGMSPEQNANTPNYLFSVDDVQSFLHARLFGAPISAFITTPTNELQAFALHGDVPSKLSIALVAIPLMVIAGIATHMNARASVARQTPEAAANPQAAIMNKLALYVFPLGVLVGGPFLPIAILIYWVSNNIWTYGQQHLVFGRMAKEEEEKKKLLMEKRAQNAPKPGAKPVDTRKKAQRPDPSQLKDAAELQDAAELQDAPSSTNGTSAAHTPNKSGGQRRPSGQKRPGGRGRANQKRRR
>NZ_CP046172.1|WP_167478876.1|10012353_10012755_-|membrane-protein-insertion-efficiency-factor-YidD
MNRRSIGVIARWPANILIFLIELYRTYVSPTRMPVCRFTPTCSEYAVTALRTRGLFIGLGLTAVRLAKCAPWHPGGWDPVPERRRSTVRTAPDEATADLAPQDIDLPSAAASEPKACKGSPRAVIGDTNDGSS
>NZ_CP046172.1|WP_167478877.1|10012751_10013198_-|ribonuclease-P-protein-component
MLPEPYRLHHRADFSRTVRRGQRIGRRDLVVHVLVHGYDGSVGASGREDGPAPAGPLVRVGGPRFGLIVSKAVGSAVVRHRVARRLRHMCARVIPELPVEADVVIRALPGAADAGSDELLRQLRGALRKLGVARDPGTAVGAGSGGRS
>NZ_CP046172.1|WP_058854877.1|10013219_10013363_-|50S-ribosomal-protein-L34
MAKGKRTFQPNNRRRARVHGFRLRMRTRAGRAIVSARRRKGRGTLTA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP046172_19	19.2\|10002787\|23\|NZ_CP046172\|CRISPRCasFinder	10002787-10002809	23	NZ_CP046172.1	5299864-5299886	2	0.913
NZ_CP046172_19	19.2\|10002787\|23\|NZ_CP046172\|CRISPRCasFinder	10002787-10002809	23	NZ_CP046172.1	10002852-10002874	2	0.913

1. spacer 19.2|10002787|23|NZ_CP046172|CRISPRCasFinder matches to position: 5299864-5299886, mismatch: 2, identity: 0.913

gctgatcgccgcccgctgatcgc	CRISPR spacer
gccgatcgctgcccgctgatcgc	Protospacer
**.******.*************

2. spacer 19.2|10002787|23|NZ_CP046172|CRISPRCasFinder matches to position: 10002852-10002874, mismatch: 2, identity: 0.913

gctgatcgccgcccgctgatcgc	CRISPR spacer
gctgcccgccgcccgctgatcgc	Protospacer
**** .*****************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP046172_5	5.1\|2576551\|25\|NZ_CP046172\|CRISPRCasFinder	2576551-2576575	25	CP042595	Streptomyces albogriseolus strain LBX-2 plasmid pSALBX2, complete sequence	146045-146069	3	0.88
NZ_CP046172_2	2.1\|826523\|25\|NZ_CP046172\|CRISPRCasFinder	826523-826547	25	NZ_CP021071	Mesorhizobium sp. WSM1497 plasmid pWSM1497, complete sequence	379559-379583	4	0.84
NZ_CP046172_2	2.1\|826523\|25\|NZ_CP046172\|CRISPRCasFinder	826523-826547	25	NZ_CP015065	Mesorhizobium ciceri biovar biserrulae strain WSM1284 plasmid pMc1284, complete sequence	382914-382938	4	0.84
NZ_CP046172_2	2.1\|826523\|25\|NZ_CP046172\|CRISPRCasFinder	826523-826547	25	NZ_CP015063	Mesorhizobium ciceri strain CC1192 plasmid pMc1192, complete sequence	495834-495858	4	0.84
NZ_CP046172_2	2.1\|826523\|25\|NZ_CP046172\|CRISPRCasFinder	826523-826547	25	NC_014918	Mesorhizobium ciceri biovar biserrulae WSM1271 plasmid pMESCI01, complete sequence	140149-140173	4	0.84
NZ_CP046172_5	5.1\|2576551\|25\|NZ_CP046172\|CRISPRCasFinder	2576551-2576575	25	NZ_CP016618	Microvirga ossetica strain V5/3m plasmid unnamed3, complete sequence	4943-4967	4	0.84
NZ_CP046172_5	5.1\|2576551\|25\|NZ_CP046172\|CRISPRCasFinder	2576551-2576575	25	MF766045	Streptomyces phage Daudau, complete genome	38584-38608	4	0.84
NZ_CP046172_5	5.1\|2576551\|25\|NZ_CP046172\|CRISPRCasFinder	2576551-2576575	25	NZ_CP016620	Microvirga ossetica strain V5/3m plasmid unnamed4, complete sequence	464597-464621	4	0.84
NZ_CP046172_10	10.1\|6114384\|32\|NZ_CP046172\|CRISPRCasFinder	6114384-6114415	32	NZ_CP026517	Deinococcus sp. NW-56 plasmid unnamed1, complete sequence	149405-149436	8	0.75
NZ_CP046172_10	10.1\|6114384\|32\|NZ_CP046172\|CRISPRCasFinder	6114384-6114415	32	NC_016585	Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence	171951-171982	9	0.719
NZ_CP046172_16	16.1\|8647880\|34\|NZ_CP046172\|CRISPRCasFinder	8647880-8647913	34	NC_022590	Brevibacterium sp. Ap13 plasmid pAP13, complete sequence	89844-89871	10	0.706

1. spacer 5.1|2576551|25|NZ_CP046172|CRISPRCasFinder matches to CP042595 (Streptomyces albogriseolus strain LBX-2 plasmid pSALBX2, complete sequence) position: , mismatch: 3, identity: 0.88

gtcctcggaccgggccgcttcctct	CRISPR spacer
gacctcggaccgggccggtccctct	Protospacer
* *************** *.*****

2. spacer 2.1|826523|25|NZ_CP046172|CRISPRCasFinder matches to NZ_CP021071 (Mesorhizobium sp. WSM1497 plasmid pWSM1497, complete sequence) position: , mismatch: 4, identity: 0.84

actgctccgaaagccgggtcgatgt	CRISPR spacer
gctgctccgaaattcgggtcgatgg	Protospacer
.*********** .**********

3. spacer 2.1|826523|25|NZ_CP046172|CRISPRCasFinder matches to NZ_CP015065 (Mesorhizobium ciceri biovar biserrulae strain WSM1284 plasmid pMc1284, complete sequence) position: , mismatch: 4, identity: 0.84

actgctccgaaagccgggtcgatgt	CRISPR spacer
gctgctccgaaattcgggtcgatgg	Protospacer
.*********** .**********

4. spacer 2.1|826523|25|NZ_CP046172|CRISPRCasFinder matches to NZ_CP015063 (Mesorhizobium ciceri strain CC1192 plasmid pMc1192, complete sequence) position: , mismatch: 4, identity: 0.84

actgctccgaaagccgggtcgatgt	CRISPR spacer
gctgctccgaaattcgggtcgatgg	Protospacer
.*********** .**********

5. spacer 2.1|826523|25|NZ_CP046172|CRISPRCasFinder matches to NC_014918 (Mesorhizobium ciceri biovar biserrulae WSM1271 plasmid pMESCI01, complete sequence) position: , mismatch: 4, identity: 0.84

actgctccgaaagccgggtcgatgt	CRISPR spacer
gctgctccgaaattcgggtcgatgg	Protospacer
.*********** .**********

6. spacer 5.1|2576551|25|NZ_CP046172|CRISPRCasFinder matches to NZ_CP016618 (Microvirga ossetica strain V5/3m plasmid unnamed3, complete sequence) position: , mismatch: 4, identity: 0.84

gtcctcggaccgggccgcttcctct	CRISPR spacer
ttcctcggacggggccgcttcgtcg	Protospacer
 ********* ********** **

7. spacer 5.1|2576551|25|NZ_CP046172|CRISPRCasFinder matches to MF766045 (Streptomyces phage Daudau, complete genome) position: , mismatch: 4, identity: 0.84

gtcctcggaccgggccgcttcctct	CRISPR spacer
gtcctcgtaccgggccgcctcctgc	Protospacer
******* **********.**** .

8. spacer 5.1|2576551|25|NZ_CP046172|CRISPRCasFinder matches to NZ_CP016620 (Microvirga ossetica strain V5/3m plasmid unnamed4, complete sequence) position: , mismatch: 4, identity: 0.84

gtcctcggaccgggccgcttcctct	CRISPR spacer
ttcctcggacggggccgcttcgtcg	Protospacer
 ********* ********** **

9. spacer 10.1|6114384|32|NZ_CP046172|CRISPRCasFinder matches to NZ_CP026517 (Deinococcus sp. NW-56 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

tccgcggctcttgcggaatcggcagctgtccc	CRISPR spacer
tgcgcggctcttgcggaatcagccgcaccagc	Protospacer
* ******************.** **  .  *

10. spacer 10.1|6114384|32|NZ_CP046172|CRISPRCasFinder matches to NC_016585 (Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence) position: , mismatch: 9, identity: 0.719

tccgcggctcttgcggaatcggcagctgtccc	CRISPR spacer
gatcctggccttgcggattcggcggctgtccc	Protospacer
  . * * .******** *****.********

11. spacer 16.1|8647880|34|NZ_CP046172|CRISPRCasFinder matches to NC_022590 (Brevibacterium sp. Ap13 plasmid pAP13, complete sequence) position: , mismatch: 10, identity: 0.706

agcgcagcgagggcaccaataggcgcagcaccag	CRISPR spacer
agcgcagcgagtgaaccaataggcacgg------	Protospacer
*********** * **********.*.*

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

9496419 : 9577264

Mycobacterium_phage(54.29%)

integrase,protease,tail

attL 9500247:9500261|attR 9573891:9573908

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_167478481.1\|9496419_9497778_+\|protease	protease	NA	NA	NA	NA
WP_167478482.1\|9497901_9499221_+\|protease	trypsin-like serine protease	NA	NA	NA	NA
WP_167478483.1\|9499319_9500174_+	NRDE family protein	Q6VZQ3	Canarypox_virus	1.9e-21	29.6
9500247:9500261	attL	NA	NA	NA	NA
WP_167479903.1\|9500315_9500672_+	MarR family transcriptional regulator	NA	NA	NA	NA
9500247:9500261	attL	NA	NA	NA	NA
WP_167479904.1\|9500689_9501058_+	hypothetical protein	NA	NA	NA	NA
WP_167478484.1\|9501239_9502469_+	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_167478485.1\|9502468_9503608_+	pimeloyl-CoA dehydrogenase small subunit	NA	NA	NA	NA
WP_167478486.1\|9503647_9504115_+	hypothetical protein	NA	NA	NA	NA
WP_167478487.1\|9504111_9504471_+	hypothetical protein	NA	NA	NA	NA
WP_167478488.1\|9504535_9507583_-	(Fe-S)-binding protein	NA	NA	NA	NA
WP_167478489.1\|9508052_9508748_+	hypothetical protein	NA	NA	NA	NA
WP_167478490.1\|9508819_9509524_-	hypothetical protein	NA	NA	NA	NA
WP_167478491.1\|9509525_9510413_-	hypothetical protein	A0A2L0HL30	Mycobacterium_phage	2.5e-08	71.1
WP_167478492.1\|9510409_9510742_-	hypothetical protein	A0A2P1CHP2	Mycobacterium_phage	2.5e-06	31.8
WP_167478493.1\|9510731_9510905_-	hypothetical protein	NA	NA	NA	NA
WP_167478494.1\|9511078_9511675_-	hypothetical protein	NA	NA	NA	NA
WP_167478495.1\|9511674_9512703_-	hypothetical protein	NA	NA	NA	NA
WP_167478496.1\|9512699_9513122_-	DUF2744 domain-containing protein	G9FH98	Rhodococcus_phage	1.9e-19	42.3
WP_167478497.1\|9513124_9514768_-\|tail	phage tail protein	A0A222ZIF0	Rhodococcus_phage	2.6e-165	51.0
WP_167478498.1\|9514775_9515693_-\|tail	phage tail protein	G9FH96	Rhodococcus_phage	4.9e-68	44.2
WP_167478499.1\|9515736_9519570_-\|tail	phage tail tape measure protein	A0A0M3UKA7	Mycobacterium_phage	3.8e-66	58.6
WP_167478500.1\|9519646_9519898_-	DUF5361 domain-containing protein	A0A2H4PEX5	Gordonia_phage	3.9e-12	47.0
WP_167478501.1\|9520047_9520305_-	hypothetical protein	A0A160DDA7	Gordonia_phage	1.5e-14	53.4
WP_167478502.1\|9520450_9521008_-	hypothetical protein	A0A2H4PEW8	Gordonia_phage	1.1e-46	52.7
WP_167478503.1\|9521070_9521490_-	hypothetical protein	NA	NA	NA	NA
WP_167478504.1\|9521815_9522517_-	YdcF family protein	NA	NA	NA	NA
WP_167478505.1\|9522539_9523862_+	UDP-glucose/GDP-mannose dehydrogenase family protein	A0A127AXI2	Bacillus_phage	8.6e-66	34.9
WP_167479905.1\|9524134_9525421_+	Hsp70 family protein	NA	NA	NA	NA
WP_167478506.1\|9525462_9526737_-	YibE/F family protein	NA	NA	NA	NA
WP_167478507.1\|9527122_9528370_-	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_167478508.1\|9528462_9529803_-	XRE family transcriptional regulator	NA	NA	NA	NA
WP_167478509.1\|9530335_9530785_+	hypothetical protein	NA	NA	NA	NA
WP_167478510.1\|9531220_9531820_-	dCTP deaminase	I4AZP2	Saccharomonospora_phage	1.7e-77	76.9
WP_167478511.1\|9531931_9533200_-	amidohydrolase family protein	NA	NA	NA	NA
WP_167478512.1\|9533252_9533804_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_167478513.1\|9534019_9534343_+	hypothetical protein	NA	NA	NA	NA
WP_167478514.1\|9534339_9535071_+	hypothetical protein	NA	NA	NA	NA
WP_167478515.1\|9535067_9535541_+	hypothetical protein	NA	NA	NA	NA
WP_167478516.1\|9535537_9536146_+	hypothetical protein	NA	NA	NA	NA
WP_167478517.1\|9536246_9536690_+	SnoaL-like domain-containing protein	NA	NA	NA	NA
WP_167478518.1\|9536873_9537407_-	hypothetical protein	NA	NA	NA	NA
WP_167479906.1\|9537765_9539268_+	APC family permease	NA	NA	NA	NA
WP_167478519.1\|9539536_9541138_+	hypothetical protein	NA	NA	NA	NA
WP_167478520.1\|9541967_9543443_-	hypothetical protein	NA	NA	NA	NA
WP_167479907.1\|9543928_9544792_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_167478521.1\|9546173_9546863_+	hypothetical protein	NA	NA	NA	NA
WP_167478522.1\|9547009_9547756_+	DUF4261 domain-containing protein	NA	NA	NA	NA
WP_167478523.1\|9548673_9550143_+	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_167478524.1\|9550458_9551661_-\|integrase	tyrosine-type recombinase/integrase	A0A2P1JS61	Mycobacterium_phage	1.6e-10	27.9
WP_167478525.1\|9551714_9551900_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_167479908.1\|9552163_9553447_-	hypothetical protein	V5R8V2	Mycobacterium_phage	8.8e-116	48.6
WP_167478526.1\|9553454_9554354_-	AAA family ATPase	A0A222Z0F2	Streptomyces_phage	2.3e-62	42.7
9553864:9553878	attR	NA	NA	NA	NA
WP_167478527.1\|9555196_9557002_-	DNA polymerase	U5P015	Mycobacterium_phage	1.9e-196	57.7
9553864:9553878	attR	NA	NA	NA	NA
WP_167479909.1\|9557002_9557221_-	helix-turn-helix domain-containing protein	A0A142K6D0	Mycobacterium_phage	1.3e-08	49.3
WP_167478528.1\|9557313_9557571_-	hypothetical protein	NA	NA	NA	NA
WP_167478529.1\|9557671_9558142_-	hypothetical protein	R9R4A1	Mycobacterium_phage	1.1e-20	43.6
WP_167478530.1\|9558208_9558448_-	hypothetical protein	NA	NA	NA	NA
WP_167478531.1\|9558482_9558686_-	hypothetical protein	NA	NA	NA	NA
WP_167479910.1\|9558678_9558852_-	hypothetical protein	A0A2P1JYR1	Mycobacterium_phage	1.1e-08	52.4
WP_167478532.1\|9558920_9559304_-	hypothetical protein	NA	NA	NA	NA
WP_167479911.1\|9560485_9560713_-	DUF3310 domain-containing protein	U5PXJ2	Clavibacter_phage	1.1e-05	42.2
WP_167478524.1\|9561218_9562421_-\|integrase	tyrosine-type recombinase/integrase	A0A2P1JS61	Mycobacterium_phage	1.6e-10	27.9
WP_167478525.1\|9562474_9562660_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_167479908.1\|9562923_9564207_-	hypothetical protein	V5R8V2	Mycobacterium_phage	8.8e-116	48.6
WP_167478526.1\|9564214_9565114_-	AAA family ATPase	A0A222Z0F2	Streptomyces_phage	2.3e-62	42.7
WP_167479909.1\|9567760_9567979_-	helix-turn-helix domain-containing protein	A0A142K6D0	Mycobacterium_phage	1.3e-08	49.3
WP_167478528.1\|9568071_9568329_-	hypothetical protein	NA	NA	NA	NA
WP_167478529.1\|9568429_9568900_-	hypothetical protein	R9R4A1	Mycobacterium_phage	1.1e-20	43.6
WP_167478530.1\|9568966_9569206_-	hypothetical protein	NA	NA	NA	NA
WP_167478531.1\|9569240_9569444_-	hypothetical protein	NA	NA	NA	NA
WP_167479912.1\|9569436_9569877_-	hypothetical protein	A0A2P1JYR1	Mycobacterium_phage	2.7e-08	52.4
WP_167478533.1\|9570209_9570980_-	hypothetical protein	A0A2P1N265	Mycobacterium_phage	2.3e-95	62.1
WP_167478534.1\|9570976_9571444_-	DUF3310 domain-containing protein	U5PXJ2	Clavibacter_phage	4.4e-09	47.8
WP_167478535.1\|9571588_9571858_-	NrdH-redoxin	X2KRY7	Enterococcus_phage	5.7e-09	41.3
WP_167478536.1\|9571854_9572496_-	topoisomerase	A0A088FWB0	Mycobacterium_phage	1.6e-73	59.5
WP_167478537.1\|9572777_9573428_-	hypothetical protein	NA	NA	NA	NA
WP_167479913.1\|9573424_9573880_-	hypothetical protein	U5P3X1	Mycobacterium_phage	2.0e-38	56.7
WP_167479914.1\|9573907_9574717_-	AAA family ATPase	A0A088FWM7	Mycobacterium_phage	7.5e-105	70.8
WP_167478538.1\|9574728_9575514_-	phage antirepressor Ant	A0A2H4J297	uncultured_Caudovirales_phage	1.1e-36	40.9
WP_167479915.1\|9575670_9576447_-	PD-(D/E)XK nuclease family protein	R9R4J9	Mycobacterium_phage	5.5e-89	59.2
WP_167478539.1\|9576437_9576665_-	hypothetical protein	NA	NA	NA	NA
WP_167478540.1\|9576757_9577264_-	XRE family transcriptional regulator	A0A222ZIZ0	Rhodococcus_phage	7.3e-42	52.8

DBSCAN-SWA_2

9591623 : 9605167

Gordonia_phage(40.0%)

portal,head,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_167478551.1\|9591623_9592337_+	hypothetical protein	A0A161C3Y8	Propionibacterium_phage	3.8e-52	49.1
WP_167478552.1\|9592303_9593047_+	hypothetical protein	G1D580	Mycobacterium_phage	7.5e-35	37.7
WP_167478553.1\|9593090_9594557_+\|portal	phage portal protein	A0A159B6N0	Tsukamurella_phage	1.2e-129	52.3
WP_167478554.1\|9594553_9595261_+	hypothetical protein	A0A166XYN9	Gordonia_phage	1.2e-45	38.4
WP_167478555.1\|9595323_9595869_+	hypothetical protein	R4JQP4	Mycobacterium_phage	2.0e-13	37.1
WP_167478556.1\|9595887_9596289_+\|head	head decoration protein	A0A162E0Z2	Gordonia_phage	1.8e-27	50.0
WP_167478557.1\|9596304_9597342_+	hypothetical protein	A0A159B6B2	Gordonia_phage	2.7e-91	53.3
WP_167478558.1\|9597955_9598321_+	hypothetical protein	A0A2H4J5S1	uncultured_Caudovirales_phage	1.1e-15	38.7
WP_167478559.1\|9598323_9598503_+	hypothetical protein	NA	NA	NA	NA
WP_167478560.1\|9598502_9598772_+	hypothetical protein	NA	NA	NA	NA
WP_167478561.1\|9598755_9599166_+	hypothetical protein	NA	NA	NA	NA
WP_167478562.1\|9599213_9599807_+\|tail	phage tail protein	A0A2H4PEW8	Gordonia_phage	2.4e-20	34.5
WP_167478563.1\|9599904_9600216_+	hypothetical protein	NA	NA	NA	NA
WP_167478564.1\|9600404_9600599_+	hypothetical protein	NA	NA	NA	NA
WP_167478565.1\|9600727_9605167_+	hypothetical protein	A0A2H4JDP5	uncultured_Caudovirales_phage	5.4e-96	27.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP046172

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection