CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP047055	Clavibacter michiganensis subsp. michiganensis strain VL527 plasmid pVL1, complete sequence	0 crisprs	NA	0	0	0	0
NZ_CP047054	Clavibacter michiganensis subsp. michiganensis strain VL527 chromosome, complete genome	3 crisprs	csa3,DEDDh,WYL,cas3	0	6	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP047054_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP047054_1

589412-589593

Orphan

Consensus_repeat	Method
TCGGCATCGCCGGATCCGCCG	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP047054_1

>merge|NZ_CP047054|1|589412-589593|PILER-CR
CGGCATCGCCGCATCCGCCACGACCGCGTACGTCCTCCTCCTCGGCGCCGGGGGCATCGGCTCCGGCGCGAGCCTCGCGGCGTTCAGCATCGCCGGATCCGCCGGGCTCCTCGCCGGTGCCGCGTTCGTCGCCGCGCGCGGGGACCGGACCCCGCGGCTCGTCGCCATCGCCGGGTCCGCCG

>NZ_CP047054|1|1|589412-589593|PILER-CR
CGGCATCGCCGCATCCGCCAC	GACCGCGTACGTCCTCCTCCTCGGCGCCGGGGGCATCGGCTCCGGCGCGAGCCTCGCGGCGTT
CAGCATCGCCGGATCCGCCGG	GCTCCTCGCCGGTGCCGCGTTCGTCGCCGCGCGCGGGGACCGGACCCCGCGGCTCGT
CGCCATCGCCGGGTCCGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP047054.1\|WP_087197895.1\|599825_600920_-\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_CP047054.1\|WP_011931694.1\|581083_581671_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047054.1\|WP_011931706.1\|591885_592056_-\|CsbD-family-protein	unknown	unknown	gnl\|CDD\|283241
NZ_CP047054.1\|WP_160444588.1\|596146_597412_+\|DUF4190-domain-containing-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP047054.1\|WP_087197214.1\|592240_592660_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379161
NZ_CP047054.1\|WP_086505250.1\|583681_584236_-\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|236608
NZ_CP047054.1\|WP_087197212.1\|592748_594923_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223588
NZ_CP047054.1\|WP_011931704.1\|589979_590777_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319832
NZ_CP047054.1\|WP_079533626.1\|583034_583685_-\|Asp23/Gls24-family-envelope-stress-response-protein	unknown	unknown	gnl\|CDD\|377129
NZ_CP047054.1\|WP_086505903.1\|594942_595950_-\|site-specific-DNA-methyltransferase	unknown	unknown	gnl\|CDD\|334588
NZ_CP047054.1\|WP_011931705.1\|590906_591812_+\|metallophosphatase	unknown	unknown	gnl\|CDD\|277347
NZ_CP047054.1\|WP_079531436.1\|597570_598470_+\|DUF4190-domain-containing-protein	unknown	unknown	gnl\|CDD\|379388
NZ_CP047054.1\|WP_011931699.1\|584368_584842_+\|Asp23/Gls24-family-envelope-stress-response-protein	unknown	unknown	gnl\|CDD\|377129
NZ_CP047054.1\|WP_160444587.1\|586510_588604_+\|large-membrane-associated-protein	unknown	unknown	gnl\|CDD\|237057
NZ_CP047054.1\|WP_086506891.1\|581759_582596_-\|exodeoxyribonuclease-III	unknown	unknown	gnl\|CDD\|197320
NZ_CP047054.1\|WP_079531411.1\|582655_583051_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047054.1\|WP_086505898.1\|585956_586511_+\|orotate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234771
NZ_CP047054.1\|WP_087197897.1\|598547_599792_+\|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|226363
NZ_CP047054.1\|WP_011931693.1\|580096_580954_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP047054.1\|WP_167604198.1\|585014_585890_+\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224995

Protein	Function_ID	Function_description	E-value
NZ_CP047054.1\|WP_087197895.1\|599825_600920_-\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	2.79066e-18
NZ_CP047054.1\|WP_011931706.1\|591885_592056_-\|CsbD-family-protein	gnl\|CDD\|283241	pfam05532, CsbD, CsbD-like. CsbD is a bacterial general stress response protein. It's expression is mediated by sigma-B, an alternative sigma factor. The role of CsbD in stress response is unclear.	0.000177598
NZ_CP047054.1\|WP_160444588.1\|596146_597412_+\|DUF4190-domain-containing-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	5.46235e-10
NZ_CP047054.1\|WP_087197214.1\|592240_592660_+\|hypothetical-protein	gnl\|CDD\|379161	pfam13396, PLDc_N, Phospholipase_D-nuclease N-terminal. This family is often found at the very N-terminus of proteins from the phospholipase_D-nuclease family, PLDc, pfam00614. However, a large number of members are full-length within this family.	4.25371e-08
NZ_CP047054.1\|WP_086505250.1\|583681_584236_-\|RNA-polymerase-sigma-factor	gnl\|CDD\|236608	PRK09652, PRK09652, RNA polymerase sigma factor RpoE; Provisional.	3.72255e-36
NZ_CP047054.1\|WP_087197212.1\|592748_594923_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|223588	COG0514, RecQ, Superfamily II DNA helicase [DNA replication, recombination, and repair].	6.32254e-124
NZ_CP047054.1\|WP_011931704.1\|589979_590777_-\|HAD-family-hydrolase	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.27441e-124
NZ_CP047054.1\|WP_079533626.1\|583034_583685_-\|Asp23/Gls24-family-envelope-stress-response-protein	gnl\|CDD\|377129	pfam03780, Asp23, Asp23 family, cell envelope-related function. The alkaline shock protein Asp23 was identified as an alkaline shock protein that was expressed in a sigmaB-dependent manner in Staphylococcus aureus. Following an alkaline shock Asp23 accumulates in the soluble protein fraction of the S. aureus cell. Asp23 is one of the most abundant proteins in the cytosolic protein fraction of stationary S. aureus cells, with a copy-number of >25000 per cell. A second Asp23-family protein, AmaP, which is encoded within the asp23-operon, is required to localize Asp23 to the cell membrane. The overall function for the family is thus a cell envelope-related one in Gram-positive bacteria.	1.44331e-07
NZ_CP047054.1\|WP_086505903.1\|594942_595950_-\|site-specific-DNA-methyltransferase	gnl\|CDD\|334588	pfam01555, N6_N4_Mtase, DNA methylase. Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.	3.70998e-48
NZ_CP047054.1\|WP_011931705.1\|590906_591812_+\|metallophosphatase	gnl\|CDD\|277347	cd07402, MPP_GpdQ, Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain. GpdQ (glycerophosphodiesterase Q, also known as Rv0805 in Mycobacterium tuberculosis) is a binuclear metallophosphoesterase from Enterobacter aerogenes that catalyzes the hydrolysis of mono-, di-, and triester substrates, including some organophosphate pesticides and products of the degradation of nerve agents. The GpdQ homolog, Rv0805, has 2',3'-cyclic nucleotide phosphodiesterase activity. GpdQ and Rv0805 belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.54512e-47
NZ_CP047054.1\|WP_079531436.1\|597570_598470_+\|DUF4190-domain-containing-protein	gnl\|CDD\|379388	pfam13828, DUF4190, Domain of unknown function (DUF4190). This integral membrane domain is functionally uncharacterized. One of the membrane helices contains two GXXG motifs that are usually associated with dimerization.	1.36315e-07
NZ_CP047054.1\|WP_160444587.1\|586510_588604_+\|large-membrane-associated-protein	gnl\|CDD\|237057	PRK12323, PRK12323, DNA polymerase III subunit gamma/tau.	2.04227e-12
NZ_CP047054.1\|WP_086506891.1\|581759_582596_-\|exodeoxyribonuclease-III	gnl\|CDD\|197320	cd09086, ExoIII-like_AP-endo, Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases. This subfamily includes Escherichia coli ExoIII, Neisseria meningitides NExo,and related proteins. These are ExoIII family AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiencies. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity. For example, Neisseria meningitides Nape and NExo, and exonuclease III (ExoIII) and endonuclease IV (EndoIV) in Escherichia coli. NExo and ExoIII are found in this subfamily. NExo is the non-dominant AP endonuclease. It exhibits strong 3'-5' exonuclease and 3'-deoxyribose phosphodiesterase activities. Escherichia coli ExoIII is an active AP endonuclease, and in addition, it exhibits double strand (ds)-specific 3'-5' exonuclease, exonucleolytic RNase H, 3'-phosphomonoesterase and 3'-phosphodiesterase activities, all catalyzed by a single active site. Class II AP endonucleases have been classified into two families, designated ExoIII and EndoIV, based on their homology to the Escherichia coli enzymes ExoIII and endonuclease IV (EndoIV). This subfamily belongs to the ExoIII family; the EndoIV family belongs to a different superfamily.	6.45212e-113
NZ_CP047054.1\|WP_011931699.1\|584368_584842_+\|Asp23/Gls24-family-envelope-stress-response-protein	gnl\|CDD\|377129	pfam03780, Asp23, Asp23 family, cell envelope-related function. The alkaline shock protein Asp23 was identified as an alkaline shock protein that was expressed in a sigmaB-dependent manner in Staphylococcus aureus. Following an alkaline shock Asp23 accumulates in the soluble protein fraction of the S. aureus cell. Asp23 is one of the most abundant proteins in the cytosolic protein fraction of stationary S. aureus cells, with a copy-number of >25000 per cell. A second Asp23-family protein, AmaP, which is encoded within the asp23-operon, is required to localize Asp23 to the cell membrane. The overall function for the family is thus a cell envelope-related one in Gram-positive bacteria.	3.41505e-23
NZ_CP047054.1\|WP_086505898.1\|585956_586511_+\|orotate-phosphoribosyltransferase	gnl\|CDD\|234771	PRK00455, pyrE, orotate phosphoribosyltransferase; Validated.	1.44562e-64
NZ_CP047054.1\|WP_087197897.1\|598547_599792_+\|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl\|CDD\|226363	COG3844, COG3844, Kynureninase [Amino acid transport and metabolism].	9.21912e-110
NZ_CP047054.1\|WP_011931693.1\|580096_580954_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	6.05595e-65
NZ_CP047054.1\|WP_167604198.1\|585014_585890_+\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|224995	COG2084, MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism].	5.05127e-64

>NZ_CP047054.1|WP_160444587.1|586510_588604_+|large-membrane-associated-protein
MSGAPGGGSGHGHDDDDPFAVRPATDADRERPAQPLAPIGWGRPAGREPVPAEQDAAEQDDAGVDPAPADAPQPPDADILAGIVPLDPTEDDARVAPLDQVDPDQDAHDHDADLDAPAPEPGIADAPIDAGDVEFPGEPDPGYVPDPAADGTGEAMSGEVEADPAPGDDAPAEMVLEPVDDAQDGAALPVVPADAPVVDAELVEDPAAPADPDDDDAVQLTPLRDDMTDEDAEVVHDPADEVEPEPLGELDVDAEAAPAPLAPAAAAARAAAMAWASGSAPAAAPAAAAPAAPPATPADAAPIADRPDAAPEPEPEPEPEPEPEPEPEPAPAPEPETAVLSSPVVAPSDAERAPDHDAEPRDEVAPTDPTPAPSSFAPPDATDADHDAEPVDAISLLFGDVAVDPESDRADADADDRRTAPEGADDRTRILPAAAPAAAPRPDRDAPTAAVPAASPRPDPTPRPAPVPPPYAAPPAPRAPAPRAPVLDTVRMPAPPAAAPPRGPRGPRRTGLWVGGAILLVLLLVGLFYLGQRLGSAAAPDAAPVATATPEATPTPSPTPTDPVQGPAAAGVQVWDALLGGECIDPYTTPWEEEFTVVDCGSEHHAQMVARVALPQTGDTFPGEEAVRDSADELCIADTVIDYAAARGYSDVQYQSAYPISQDEWTAGDRDAYCFVSRAGGGTFTNSIGKPQPPVVP
>NZ_CP047054.1|WP_086505898.1|585956_586511_+|orotate-phosphoribosyltransferase
MTTSDARQQLIAHIKEDAVFHGDFTLTSGKKATYYVDLRRVSLDHRVAPLIGQVMLDLIADVPDVAAVGGLTMGADPIAAAILHQGAAVGRGYDAFVVRKEPKDHGRGRQVEGPDLKGKRVIVVEDTSTTGGSPLKAIEALEKVGAEIAAVAVVVDRSTDAREVIEAAGHRYLYAIGLEDLGLA
>NZ_CP047054.1|WP_167604198.1|585014_585890_+|NAD(P)-dependent-oxidoreductase
MALLGAGVMGSGMSRSILRAGLPLTVWNRSAEKAAPLADAGATVAETAADAVRDADVVVVMLFDADAVLEVLAEVAPALRPGAVVLQSSTVGVEGTRRIAALAAEHGVRLVDAPVLGTRGPAEQGLLVHLVSGSEDDIAVSRPVLEATGSRTVVAGSDAGPGSALKLACNAWIASITAATGQSLGLARLLGVEPRLFLDAIAGGAADTPYAHLKGGAMLAGELAPSFALDGLLKDVTLMLAALDGADAHDFDTAMLEALRETYAEASSAGHGGDDVAAVGTVFGLPTGPDA
>NZ_CP047054.1|WP_011931699.1|584368_584842_+|Asp23/Gls24-family-envelope-stress-response-protein
MSDQNTSTPADVARVSPASTGASTGATGSVLAEGDTTVTDAVIAKVAGLAVRDIPGVHALGGGAARVIGQLRDRIGQTDLTQGIAVDAQEAGVAFEVTLVAEYGVPLQDVAAGVRAAISDAVTELVGRRVTRVDVTIADIVLPGEGSDDDASAAPAV
>NZ_CP047054.1|WP_086505250.1|583681_584236_-|RNA-polymerase-sigma-factor
MALSSSLQDAGDGILAERAADGDARAFEVLVRRHAPYMRAFAIRLTGSRADADDAVQEALITAWDRLPTLEKPDRVKSWLLQIVSRKSIDRIRARRPADDIDDHEIADRLTSPERDAETSSQMRALAAVLDALPREQREVWMLREVGGFSYEEIAEKLGSTPSTVRGRLSRARTTVMTSMEEWR
>NZ_CP047054.1|WP_079533626.1|583034_583685_-|Asp23/Gls24-family-envelope-stress-response-protein
MSGTGPGDPGERLPVDPAPALDADGAPLDMAALADYLDRGRTPRIAAYEDDPETRNALRALEHMRDLGRELVQVEAEEQEAPGDDFFRGVLAHISRESRAGRDIPLSHPDPAVRLALTEGAVRTLVRQAGDEVPGVLVGRCTLDGDVTRAGEPVRVELTLSVVWGEPLPELAQRVRERVHAALLRHTELRVEAIDVTVVDVQARPVQEEAGDDPRR
>NZ_CP047054.1|WP_079531411.1|582655_583051_-|hypothetical-protein
MTLDDDASAAPAPVPVPLPAPADLSRDLTAVLRAVAGVADVYAPRSPILLAAQQVVEGVVAGSSTAVEQLVTVETGEGTVLVEASIAVDASGRASDTARAAVDAIRARLAESMGAEAAERAAVTVRIGSIG
>NZ_CP047054.1|WP_086506891.1|581759_582596_-|exodeoxyribonuclease-III
MRVATWNVNSIRTRVGRVVDWLVREDVDVLAMQEIKCKPEQFPMQAFEEAGYEVAVHGLSQWNGVAIASRLPLEDVVTTFEGMPRFGKPDASGQPPLEARAMGATVAGVRLWSLYVPNGRALDDPHYSYKLEWLGALAADTRAWLASDPATPLALMGDWNVAPLDTDVWDPALFEGKTHTSEPERAAFAAFLDAGLADVVRPSIPEGYTYWDYQQLRFPRNEGMRIDFILGNDRFQELVGSPRIHRDERKGDGPSDHVPVAVDLDVETELDDDRPMIF
>NZ_CP047054.1|WP_011931694.1|581083_581671_-|hypothetical-protein
MTPDDDATPERGRRASRGRRSATPPARRRRLPEVPRIALPTLPRGRGRADDRSETRAAARSAARDDDPAGPDWVPRWILRIDRRILVTTLVSMLVAAVVGGSIAAMGLGLIFVTDACDVDAYVCRDSLFTIGYGIAVAGPLFLTGIAVIVALVGMIRGRTRPWLVLLIGVGASLAAYVLGAVLVLVAVPGSSPIT
>NZ_CP047054.1|WP_011931693.1|580096_580954_-|response-regulator-transcription-factor
MDSGRVALVIEDDGDIRQLLEVVLRQGGFEVHSAGTATEGVRLAEEVSPDVITLDVGLPDFDGFEAARRIRLVSDAYIVMLTAQGEEVDTLLGLEAGADDYIVKPFRPRELRARISAMMRRPRGGGDATATPAAGIPAAADASGTAADADEPVQAAAVATTAVVSPAMPTEAAPDDADVLRHNGLELDEGTRHVTVDGAPVDLTRTEFDLLASILASGGRVRTKGDLVRDIRSGSYAVASSTEPEERAVEVHLGNLRRKLHDDPREARWIQTVRGVGYRLAPPRG
>NZ_CP047054.1|WP_011931704.1|589979_590777_-|HAD-family-hydrolase
MATRDEMDCWLTDMDGVLVHENQALPGAAALIQQWQDQGKPFLVLTNNSIFTPRDLSARLRASGLHVPEESIWTSALATAAFLEQQMPGGSAFVIGEAGLTTALHEAGFIMTDTKPDFVVIGETRNYSFEAITRAIRLINGGARYIATNPDATGPSAEGVLPATGAVLALISKATGKEPYIVGKPNPMMFRSALNKIGAHSESTGMIGDRMDTDIIAGIEAGLHTVLVLTGISDRAEIERYPFRPDEVLSGVTELLDPEPVESEL
>NZ_CP047054.1|WP_011931705.1|590906_591812_+|metallophosphatase
MHALPPGSLRLVHLSDTHLLRDGGLHQGVVDTGAALERVLVEADRVPEVRLLVGSGDLSEDGTAESYALLRERLVPWTSSRGAALVLTPGNHDVRSAFRLVLGDGHGAPGTDDGRDPAAVPPVDGVTIVDGWRIATLDTSVPGKGYGALREQQLDGLRELLATPAEHGTVLVLHHPPVPAPTTLHESLALQGPERLAEIVRGSDVRVILSGHYHHHIVGSLAGVPVLVAPGVANETDVAAEPGTERIVRGSGFLVVDVRPDGRVTSVVVRAHAEDDGDEVALLDAGLVQRIIADSGAPAAP
>NZ_CP047054.1|WP_011931706.1|591885_592056_-|CsbD-family-protein
MGLDDKIKNAAQDIAGKAKEALGDHKGDENLKAEGQKDQAAASAKKAGEDVKDVFK
>NZ_CP047054.1|WP_087197214.1|592240_592660_+|hypothetical-protein
MILFGLLPLLVAVCALVDVITRPDDQVKHLPKLVWILLIVFLPLTGSIVWFCVGHDWDARREPVGPPDRSAAYERAAAAVDLRVRSTEQQLADLEEEERHYARIARMRQLQAEQAVQAARAAGPARAPRAIEPGSTPEP
>NZ_CP047054.1|WP_087197212.1|592748_594923_+|DEAD/DEAH-box-helicase
MPDTATPPSSAAPSDLRSAAREHLSRLVGVAGADFHDGQFEAIEALVQDRSRALVVQRTGWGKSAVYFVATLLLRQQGLGPTLLVSPLLALMRDQVAAARRAGVRAVAMNSSNAHEWDDLLRALDADEVDLLLVSPERLNNPRFRDEQLPALRARLGLLVVDEAHCISDWGHDFRPDYRRLRDLISSVDERVPVLATTATANSRVVADVEEQLSVGSAGAGVVETDRVPVVTIRGPLARRSLRLGVLRLENSRDRLGWLLSHLDALPGSGIIYALTVSAAQDTARLLRDAGHAVKAYTGRDDPADREQAEGELQRNEVKALVATSALGMGFDKPDLGFVVHLGAPSSPVSYYQQVGRAGRGSADADVLLLPGREDPDIWQYFATASMPDEQQAAAVIQALGESDRPLSVPALESRVSLSRSRLDLLLKVLDVDGAVRRDTSGWSATGVPWVYDRARYEQVAAARVREQQAMLDYETTLGCRMEFLQRQLDDDTAAPCGRCDRCAGAWYPSSLDQQASATASQALDRVGLPIEPRLRWPTGASTVGVPLSGAIAAGEQVDEGRALARLTDLGWGGRLRTVFAAGAEDAPVDDALVAACVRVLAEWGWAERPRAVIHVPSASRPQLVGSLAQRIAEVGRLPFLGSLDLVDPGAPGAARGNSVYRLGRVHPRFQVPAHLADDLAGDPRPVLLVDDLVDTRWTLTVAGRLLRKAGATRVLPFALAQQG
>NZ_CP047054.1|WP_086505903.1|594942_595950_-|site-specific-DNA-methyltransferase
MIHAENLEAVRALPDGAFQLIYLDPPFNTGRTQERQNLTVTRTPDPAAGPDADAESVADPAIALDAAAAPAPGTAAERATPVALAPASTATPEPVRPPGARLGFHGRSYDSVKGMLYGFDDSFADYWDFLEPRLIEAWRLLDPTGTLYLHLDYREVHYAKVVLDALFGRRSFLNEIVWAYDYGAKSRRRWPAKHDTILVYVKDPVRYRFDSEGVDREPYMAPGLVTPEKRERGKLPTDVWWHTIVSPTGREKTGYATQKPLGVLRRIVQASSRPGDWVLDFFAGSGTTGAAARELGRRFVLVDENPQAVEVMRARLAGGGTVFVEPETEPDPVAG
>NZ_CP047054.1|WP_160444588.1|596146_597412_+|DUF4190-domain-containing-protein
MSDDRDPGRTDGPHPDEPRGGDPAAEEPAAAGPAAERPAAEGPAAEPAAAGPAQGEASAAGATADPVSPYGPPAVPPAAAPEPAAAPEPADEPAHPAPPQPPAGYDAATGSAGAGSGSGSGAGPGFAAPGPSYAPPVGAAPPAAPAPPYVSGPPPRPRGGKGLAIAALVVGIAGVLGAFIPFLNYVTAIPALVAVVLGIVSLARRMDGKPLALTGLILGAVGFVLSIVLAFVYTFAFVSTVTDAVESAGTDPGFASPAPTYGSGGDDAAAQPGTSPDDPLPIGTPVTGEGVDGPEWRVTLGTPILDATAAVLAADPTNGPPEEGMQYAVVPVTATYLGSSTGDPLSELALGFLAPDGTQYSAADSFVQAPAPAFTDASAMLEPQGTASGNVVVEIPIDGAADGLWATAPGMIADAYYFRAG
>NZ_CP047054.1|WP_079531436.1|597570_598470_+|DUF4190-domain-containing-protein
MTDARDPNSTPEQHSYPAPPPAPEGGYATPYAPAAPAGPSGGKGLAIASLIVAIVAFLGAFVPFLNYVVFIPAIVAIVLAIVALARHKAGKPLALGGLIVGVLALVLSIILAVVYTLGFAAAVSESLPRSEGGSGSSAAPLDETEEEAGPAVGTRENPAPIGTVVTGLSGGSPQWEVTLGAPVLDANAAVTSENMFNDPAPAGTQYAMVPVTVKYVGTESASPMFEIGVEYVSAAGTTHTTSDSFAVAPEPQFDSINELFPGASGTGNVVIAIPSADAAAGTWAVRPGILADPYYFAAQ
>NZ_CP047054.1|WP_087197897.1|598547_599792_+|aminotransferase-class-V-fold-PLP-dependent-enzyme
MTPDARGTDAPSRPLPSAAELDARDPLARFRDLFVQSDDVVAYLDGNSLGRPTLASVDRVADFVRDWWGGRLIRGWDEDWLAMPTRIGDDLGRVTYGAAPGQTFVGDSTTVILYKLVRAAVRARPGRDELVIDTDNFPTDRFVLEGVAEECGMTIRWIDVAPDAGVTPELVADAVGERTALVVLSQVAYRSGFLADVSAITRLVHDAGALVLWDTCHSVGVIPTELDAWGVDLAVGCSYKYLDGGPGAPAHGYVRSDLQAELRQPIQGWMGAQDVFAMGPEYVPADGIRRFLSGTPPIVGMLAMQDMLALIEEAGMPAIRAKSLALTGFALDLVERDLVPLGARVASPREEARRGSHVSVDHPRFREIVGALWAEGVIPDFRAPSGLRLGLSPLTTSFREVEVGVDAIRRHLAG
>NZ_CP047054.1|WP_087197895.1|599825_600920_-|Gfo/Idh/MocA-family-oxidoreductase
MPHPAPTAPQIRFGIVGSGWRSAFFLRIARALPERFAVTGLVTRSADTGRALEEEWGIRTFRTAAELLAAEAPSFVVVSVPRSAAPDVIADLVDRGVAVLTETPPGATVADLERLDALVRQGARIEVAEQYPLSPLLAAQLAIAAGGRLGRISQATVAQCHDYHGVRVMRRALGIGFEDATITASRFSSPIVAGPDRDGDPVREEIVTAEQTTARFDFGDRLGVYDFSDRQYFSWIRRNRLLVRGERGEIVDEHVSWLLDATTPTWADITRVETGQGGNLEGHHLRGLLLGSEWIYENPFAPGRLADDEIAIAQCLVEMHAHAAGGPSTNPLAEASQDHHLALLMHEAAATGKPVRSTRRAWAD

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Crispr_ID: NZ_CP047054_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP047054_2

2262743-2263011

Orphan

Consensus_repeat	Method
GACCAGGGCTTGCGCTCCCCGTC	CRISPRCasFinder
CGACCAGGGCTTGCGCTCCCCATCACG	PILER-CR

4 spacers

The CRISPR arrays of NZ_CP047054_2

>merge|NZ_CP047054|2|2262743-2263011|CRISPRCasFinder,PILER-CR
GACCACGGCTTCCGCTCCCCGTCCCTCGCCGGACGCGGCGCACCCGACCCGCCATCACGCGACCAGGGCTTGCGCTCCCCATCACGCTGCGGCCGGGACGCCCCTCCACCTTCCTTCGACCAGGGCTTGCGCTCCCCGTCCCGAGCGGGACGAGCCGACCCGCCGGCACCGCCGCCATCACGAGACCAGGGCTTGCGCTCCCCATCACGCTGCGGCCGACCTGCGGCTCCACCACCGTCCTTCGACCAGGGCTTGCGCTCCCCGTCACG

>NZ_CP047054|2|1|2262743-2263008|CRISPRCasFinder
GACCACGGCTTCCGCTCCCCGTC	CCTCGCCGGACGCGGCGCACCCGACCCGCCATCACGC
GACCAGGGCTTGCGCTCCCCATC	ACGCTGCGGCCGGGACGCCCCTCCACCTTCCTTC
GACCAGGGCTTGCGCTCCCCGTC	CCGAGCGGGACGAGCCGACCCGCCGGCACCGCCGCCATCACGA
GACCAGGGCTTGCGCTCCCCATC	ACGCTGCGGCCGACCTGCGGCTCCACCACCGTCCTTC
GACCAGGGCTTGCGCTCCCCGTC

>NZ_CP047054|2|2|2262802-2263011|PILER-CR
CGACCAGGGCTTGCGCTCCCCATCACG	CTGCGGCCGGGACGCCCCTCCACCTTCCTT
CGACCAGGGCTTGCGCTCCCCGTCCCG	AGCGGGACGAGCCGACCCGCCGGCACCGCCGCCATCACG
AGACCAGGGCTTGCGCTCCCCATCACG	CTGCGGCCGACCTGCGGCTCCACCACCGTCCTT
CGACCAGGGCTTGCGCTCCCCGTCACG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP047054.1\|WP_087196366.1\|2273023_2274517_-\|argininosuccinate-lyase	unknown	unknown	gnl\|CDD\|179143
NZ_CP047054.1\|WP_087198283.1\|2259463_2260267_-\|TlyA-family-RNA-methyltransferase	unknown	unknown	gnl\|CDD\|224110
NZ_CP047054.1\|WP_012038683.1\|2274521_2275760_-\|argininosuccinate-synthase	unknown	unknown	gnl\|CDD\|234785
NZ_CP047054.1\|WP_087197066.1\|2269410_2270715_-\|tyrosine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235645
NZ_CP047054.1\|WP_079534678.1\|2271637_2272237_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047054.1\|WP_012038671.1\|2256832_2258548_-\|DNA-repair-protein-RecN	unknown	unknown	gnl\|CDD\|223571
NZ_CP047054.1\|WP_012038668.1\|2253359_2254346_-\|site-specific-tyrosine-recombinase-XerD	unknown	unknown	gnl\|CDD\|234713
NZ_CP047054.1\|WP_012038674.1\|2260334_2260544_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047054.1\|WP_050976310.1\|2278095_2279031_-\|acetylglutamate-kinase	unknown	unknown	gnl\|CDD\|239783
NZ_CP047054.1\|WP_012038675.1\|2260553_2261594_-\|HAD-IIA-family-hydrolase	unknown	unknown	gnl\|CDD\|319832
NZ_CP047054.1\|WP_012038680.1\|2272267_2272882_-\|DNA-3-methyladenine-glycosylase	unknown	unknown	gnl\|CDD\|234840
NZ_CP047054.1\|WP_012038684.1\|2275808_2276732_-\|ornithine-carbamoyltransferase	unknown	unknown	gnl\|CDD\|234835
NZ_CP047054.1\|WP_167604173.1\|2276881_2278099_-\|acetylornithine-transaminase	unknown	unknown	gnl\|CDD\|235112
NZ_CP047054.1\|WP_167435217.1\|2272889_2273027_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047054.1\|WP_086507473.1\|2270933_2271641_+\|DNA-binding-protein	unknown	unknown	unknown
NZ_CP047054.1\|WP_050976309.1\|2258540_2259500_-\|NAD-kinase	unknown	unknown	gnl\|CDD\|235121
NZ_CP047054.1\|WP_087196778.1\|2261583_2262573_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047054.1\|WP_012038669.1\|2254342_2255020_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239516
NZ_CP047054.1\|WP_012038667.1\|2252405_2253290_-\|ParA-family-protein	unknown	unknown	gnl\|CDD\|224113
NZ_CP047054.1\|WP_087198281.1\|2255016_2256759_-\|CTP-synthase	unknown	unknown	gnl\|CDD\|235437

Protein	Function_ID	Function_description	E-value
NZ_CP047054.1\|WP_087196366.1\|2273023_2274517_-\|argininosuccinate-lyase	gnl\|CDD\|179143	PRK00855, PRK00855, argininosuccinate lyase; Provisional.	0
NZ_CP047054.1\|WP_087198283.1\|2259463_2260267_-\|TlyA-family-RNA-methyltransferase	gnl\|CDD\|224110	COG1189, COG1189, Predicted rRNA methylase [Translation, ribosomal structure and biogenesis].	7.58978e-93
NZ_CP047054.1\|WP_087197066.1\|2269410_2270715_-\|tyrosine--tRNA-ligase	gnl\|CDD\|235645	PRK05912, PRK05912, tyrosyl-tRNA synthetase; Validated.	0
NZ_CP047054.1\|WP_012038671.1\|2256832_2258548_-\|DNA-repair-protein-RecN	gnl\|CDD\|223571	COG0497, RecN, ATPase involved in DNA repair [DNA replication, recombination, and repair].	9.6433e-161
NZ_CP047054.1\|WP_012038668.1\|2253359_2254346_-\|site-specific-tyrosine-recombinase-XerD	gnl\|CDD\|234713	PRK00283, xerD, tyrosine recombinase.	3.26601e-141
NZ_CP047054.1\|WP_050976310.1\|2278095_2279031_-\|acetylglutamate-kinase	gnl\|CDD\|239783	cd04250, AAK_NAGK-C, AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the non-acetylated, cyclic route of ornithine biosynthesis. In this pathway, glutamate is first N-acetylated and then phosphorylated by NAGK to give phosphoryl NAG, which is converted to NAG-ornithine. There are two variants of this pathway. In one, typified by the pathway in Thermotoga maritima and Pseudomonas aeruginosa, the acetyl group is recycled by reversible transacetylation from acetylornithine to glutamate. The phosphorylation of NAG by NAGK is feedback inhibited by arginine. In photosynthetic organisms, NAGK is the target of the nitrogen-signaling protein PII. Hexameric formation of NAGK domains appears to be essential to both arginine inhibition and NAGK-PII complex formation. NAGK-C are members of the Amino Acid Kinase Superfamily (AAK).	2.26055e-139
NZ_CP047054.1\|WP_012038675.1\|2260553_2261594_-\|HAD-IIA-family-hydrolase	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	9.9605e-77
NZ_CP047054.1\|WP_012038680.1\|2272267_2272882_-\|DNA-3-methyladenine-glycosylase	gnl\|CDD\|234840	PRK00802, PRK00802, DNA-3-methyladenine glycosylase.	6.23127e-83
NZ_CP047054.1\|WP_012038684.1\|2275808_2276732_-\|ornithine-carbamoyltransferase	gnl\|CDD\|234835	PRK00779, PRK00779, ornithine carbamoyltransferase; Provisional.	0
NZ_CP047054.1\|WP_167604173.1\|2276881_2278099_-\|acetylornithine-transaminase	gnl\|CDD\|235112	PRK03244, argD, acetylornithine transaminase.	0
NZ_CP047054.1\|WP_012038683.1\|2274521_2275760_-\|argininosuccinate-synthase	gnl\|CDD\|234785	PRK00509, PRK00509, argininosuccinate synthase; Provisional.	0
NZ_CP047054.1\|WP_050976309.1\|2258540_2259500_-\|NAD-kinase	gnl\|CDD\|235121	PRK03372, ppnK, inorganic polyphosphate/ATP-NAD kinase; Provisional.	1.65727e-170
NZ_CP047054.1\|WP_012038669.1\|2254342_2255020_-\|NUDIX-hydrolase	gnl\|CDD\|239516	cd03424, ADPRase_NUDT5, ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, for its activity. It also contains a highly conserved 23-residue Nudix motif (GX5EX7REUXEEXGU, where U = I, L or V) which functions as a metal binding site/catalytic site. In addition to the Nudix motif, there are additional conserved amino acid residues, distal from the signature sequence, that correlate with substrate specificity. In humans, there are four distinct ADPRase activities, three putative cytosolic enzymes (ADPRase-I, -II, and -Mn) and a single mitochondrial enzyme (ADPRase-m). Human ADPRase-II is also referred to as NUDT5. It lacks the N-terminal target sequence unique to mitochondrial ADPRase. The different cytosolic types are distinguished by their specificities for substrate and specific requirement for metal ions. NUDT5 forms a homodimer.	2.05618e-48
NZ_CP047054.1\|WP_012038667.1\|2252405_2253290_-\|ParA-family-protein	gnl\|CDD\|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	5.2064e-83
NZ_CP047054.1\|WP_087198281.1\|2255016_2256759_-\|CTP-synthase	gnl\|CDD\|235437	PRK05380, pyrG, CTP synthetase; Validated.	0

>NZ_CP047054.1|WP_087196778.1|2261583_2262573_-|hypothetical-protein
MRSVRPRHEDPEIPEDVKPGDLDRIARNELKTLSKDNAEGVAQHLVMAARLIEEDPELAHRHATSAARRAGRIAVVRESLAITAYAVGDYALALRELRTYRRISGKDDQLALMVDSERGQGRPDKALELGRSVPKETLPAAEQVALAIAMSGARLDLGQTEAALDELSIAQLNRDVAYSYSADLFHAYAEVLEELGRSAEADAWRQRADAAEAAFADPDEGWDDMVEVVEEDLELEDAGNDSSEHDGPGDASAVGSDGAADDAVDSSGDPLVTDEPSPPSEEGDSEEIAVDVDDELEVDGDAGDESPATDAEDEDPRADDAGEADRDVR
>NZ_CP047054.1|WP_012038675.1|2260553_2261594_-|HAD-IIA-family-hydrolase
MFARASKGSAPLEGVDVILADLDGVVYAGPDSIPHAVDALNRAAGDGIRLGYITNNASRTDASVAEHLSSLGLTVAPEDVVTSPQAALRLLADRVPAGSTVLVVGGDGLVHELEKAGYVVTRSTEDSPAAVVQGFSPDVGWAQLAEAAFALADPDVVWVATNTDWTIPVARGIAPGNGTLVSAVHTAVGRLPVVAGKPETPIFDVARERFDAQRPVFLGDRLDTDILGATRAGMASVHVLTGIDRAKQLLAAEEDQRPTFILEHLGQLHEPYPETRFSQEGRVATVGKSSVRIAGDRVEVVKDGGSTIDTLRAACAVIWNSGRPIYGLDVQESLYVAAGAAGAGRA
>NZ_CP047054.1|WP_012038674.1|2260334_2260544_-|hypothetical-protein
MSDDPDDSARAGSAPGPDSDDGRDVAEELVSRLQLIEEQPLGDRAAAFALLHDELRARLEGGDGAATRG
>NZ_CP047054.1|WP_087198283.1|2259463_2260267_-|TlyA-family-RNA-methyltransferase
MRLDAALPALGLARSRTHAARLIADGLVTVDGRGVVKASFRVMPGSVVEVAGSDAYVSRGAHKLIGALDAFPGVAVAGRLALDVGASTGGFTQVLLERGARRVVALDVGHGQLDPLIREDPRVDVVEGFNVRDLTPESLAGVTPADLAGERPGLVVGDLSFISLGLVLPAIARTAADGADVVLLIKPQFEVGRTGIREGIVHDPGLRDDAVMRVLWAAWDLGLGTAGLVSSPIVGGAGNHEYLAWFSGRAGSNPTQWRSTSNEITGA
>NZ_CP047054.1|WP_050976309.1|2258540_2259500_-|NAD-kinase
MEIDVERDHRSVSEVAGPARHILVVSHTGRRDSIDAALSVCAQLAEADVHLVLTADEKADILPFAPEMDGVAVLGEDVQTADLEIVIVLGGDGTILRSAEIVRGTSVPLLGVNLGHVGFLAESEREDLTATVRRVLDRDYTVEERMTLDVTLKVGADIVYRTWALNEATVEKASRERMLEVVVEIDGRPLASYGCDGMVVSTPTGSTAYAFSAGGPIVWPSLEAMLVVPLSPHTLFARSLVVGPESTVAVEVLSRTSGSGVLWCDGRRTRDMPPGARVEARRSAIPVRLARLKQSPFTDRLVNKFELPVTGWRGPIDRD
>NZ_CP047054.1|WP_012038671.1|2256832_2258548_-|DNA-repair-protein-RecN
MIEEITIRDLGVIGQATLPLGPGFTAVTGETGAGKTMVVTALGLLLGARADSGAVRQGSERAVVEGRWIIAADGPVPERVRDAGGDVDPFGDGSRGELIVTRQLSSEGRSRASVGGRGAPAALLTEIGEQLVVVHGQSDQMRLRSSTAQRQALDRFAGSALAPVLGEYQEVFRRWQAARAELDRLVTEQDARTREAEELRIAIDAIEAVAPQPGEDEELRERIDRLTNLEDLRAAASAAHELMSSEDASGEMADAASVLDTAHRRLDRVAAHDPGLAEIIESLDSARILVSEIAVQLSGYLAGLDADGARELETLQDRRAELAALTRAHGPTVEDALAFLDTGSARLLELDGDTDRIDLLRVEVERDELLVGELAARVTAVREEAGARLAAAVTTELGALAMADASLEVRVSPREEPALSGADRVEILLRPHAGAEARPLGRGASGGELSRVMLAIEVVVAGDDPVPTFVFDEVDAGVGGAAAIEIGRRLARLAERAQVIVVTHLAQVAAFSTNHLRVVKGGDGQVTASSVTQLEGDARIQEMARLLSGLPDSESGLAHARELVETAASLR
>NZ_CP047054.1|WP_087198281.1|2255016_2256759_-|CTP-synthase
MADINSADTDSGTTDSNTSTTGAAKTTRHIFVTGGVVSSLGKGLTAASLGNLLTARGVRVVMQKLDPYLNVDPGTMNPFQHGEVFVTDDGAETDLDIGHYERFLDIELDQAANVTTGQIYSEVIAKERRGEYLGDTVQVIPHITDEIKRRMRLQASDEPQPDVIITEIGGTVGDIESQPFIEAARQVRHELGRNNVFFVHVSLVPYMGASGEQKTKPTQHSVAALRSIGIQPDALVLRSDRPVSDSNKKKIALMCDVDEQAVVNAVDVPSIYDIPEMLHGQGLDSYIIDHLGLTAADAVDWSGWSDLLDAVHDPKHEVTVGLVGKYIDLPDAYLSVTEALRAGGFAHSARVKLRWVASDECETPEGAAKKLGDLDALCVPGGFGIRGIEGKLGALKFARDNMIPVLGLCLGLQCMVIEYARNEAGLAGASSSEFDPESEFPVVATMAEQVDIIAGGDLGGTMRLGLYEAALAPGSLAAELYGAPVSHERHRHRYEVNNQYRDRIQDAGLVFSGTSPDGTLVEYVELPREVHPFYIGTQAHPELRSRPNRAHPLFAGLIRAALDRQAASTLFVEDDAEAVA
>NZ_CP047054.1|WP_012038669.1|2254342_2255020_-|NUDIX-hydrolase
MTDAVAGSPAGGLHDDAVAYEVTSSERVFQGKIWDIRRETFAYGDGEITREFVDHTGAVAVLAIDDEDRVLLIKQYRHPVRMREWEIPAGLLDITGEPPLTAVQRELAEEADLVAAEWSVLAEYYTTPGGSDEAIRVYLARGLTPTAEAFARTDEEADIEVRWVDLDEVVTAVLERRIQNPSTVIAVLQAHVARSRGWSTLGPADAPWPRHPKLRDGDGGGASGS
>NZ_CP047054.1|WP_012038668.1|2253359_2254346_-|site-specific-tyrosine-recombinase-XerD
MTDVAEGSGGAAPDAVPEVPVALRRAVDRWLRHVEVERGLSRNTLQAYRRDLARYTAHLADEGVADPADASAAHIAAFAQRVRDPEHGGLTASSLARMLSSVRSFHRFLVEEGIVEVDVSAEQRPPKLPSRLPKAVSIETMGRILDATDGDEPLRVRDKALLELLYATGARVSEITALTVDDVLGADGAAAELVRVLGKGGKQRIVPVGSFARRAVDAYLVRVRPILAARGSATPALFLGLRGHALSRQNAWLVIKAAAERAGVAEEISPHTFRHSFATHLIAGGADVRVVQELLGHSSVATTQIYTRVTVDTLRDVYTTAHPRARRA
>NZ_CP047054.1|WP_012038667.1|2252405_2253290_-|ParA-family-protein
MTRKPDVTELPGMDVPVLGPTGRELREFAEPEPLQGHGPAKIISLCNQKGGVGKTTTAINLGASLASYGRRVLAVDFDPQGALSAGLGVQTHDAVTIYDLLLGTVKDPREAIQTTGFEGLDVIPANIDLSAAEVHLVNEVAREQILASVLRKVSADYDVILIDCQPSLGLLTVNALTASHGVLIPLECEFFALRGVALLVETIEKVKDRLNPGLALDGILATMYDSRTLHSREVLQRVVEAFDDSVLETVIGRTVKFPDASVAGKPIIQFAPEHPAALAYRKVARELIARGAVA
>NZ_CP047054.1|WP_087197066.1|2269410_2270715_-|tyrosine--tRNA-ligase
MTNADPDRLSSQRNDPSFEDVWEEIVWRGYVHVSTDQDALKELLSGPPITYYCGFDPTAPSLHLGNLVQLLLMRRLQLAGHRPLGLVGGSTGLIGDPRPTAERTLNDPEVVADWVGRVQAQVSAFLSPEGDNAVRIVNNLDWTAPMSAIDFLREVGKHFRVGTMLKKDAVSARLNSDEGISYTEFSYQILQGLDFRELHRTYGCVLQTGGSDQWGNLTSGTDLIRRSERTTAHAIGTPLITNSDGTKFGKSEGNAIWLDAELTSPYAFYQFWLNTEDGDVIQRLRLFTFLDRARIEELARAVESEPFRREAQRTLAWEVTSLVHGIEATESAIAAAQALFGQGELTALDEPTLRAAMGELPSAQIPAGTTVIQALIDTGLVSSSGEARRAITQGGVYVNNVAVGDAAAVVDALLHGRFAVIRRGKKTLAGVTVA
>NZ_CP047054.1|WP_086507473.1|2270933_2271641_+|DNA-binding-protein
MFVITADQKGSRTDVDRAGTGRDDLASRFEGRLVLPVDRTSGDELQALVADADTALDMALVLTRAGHWSVGLGIGTVRTPLPRATREATGPAFIAARDAVGAAKRSATRFALAVDPPAPPRPDGPGSDLPGSGLPGPDEVEALITLLLLARDRRTAQGWDVVDRMADGSTQREVAAALGVTPQAVSTRLRTSAWRAERAAIPGLVALLAHLDAQATRGAGAVASAPRSTRAGTRS
>NZ_CP047054.1|WP_079534678.1|2271637_2272237_+|hypothetical-protein
MIPVGTPGEITAWIALCVLVTAALVLALLTVRAPRTGRVVAAAGTLACALALGLALSGPASPLVVGFTGLVAVVLAVLGGGSASTVVLALATRGSVPPGAFGGILVAPRGHEDDASASRRPTREVLRGGATIGMLERLAVVAVILAGYPEALAVIIAIKGVGRFSELGEAAEARERFIIGTLVSWLWAATCAAVVLVVR
>NZ_CP047054.1|WP_012038680.1|2272267_2272882_-|DNA-3-methyladenine-glycosylase
MIDAAFFARDAVEVAPALLGGILSRESEEGRVSVRLTEVEAYRGVGEDPGSHAFRGKRARNATMFGPPAHLYAYFTYGMHTCANIVCGPEGTSAGVLLRAGEVVEGAELARRRRGAAVRDRDLARGPARLAVALGIPLSDDGAALDAPPYRLVLPDEPLALPAAGPRVGVSGPGGSGELFPWRFWVPGDPTVSAYRAHVPRVRR
>NZ_CP047054.1|WP_167435217.1|2272889_2273027_-|hypothetical-protein
MTLSNGRRPERPEPRHRWLLPLVIGVAVAVLVFVVVVASINGELI
>NZ_CP047054.1|WP_087196366.1|2273023_2274517_-|argininosuccinate-lyase
MTESTDPSTRAGEAGALWGGRFAGGPSPELVALSRSTHFDWQLAPYDIAGSRAHARALASAGYLSEAERQAMLQALDTLEDRVRSGALVASEADEDVHGALERGLMDIAGTELGGKLRAGRSRNDQIATLVRMYLRDHAAVIHAMLVRLVDALAAQAEAAGGAIMPGRTHLQHAQPVLLAHHLLAHCWPLVRDLERLADWDARADVSPYGSGALAGSTLGLDAGAVARDLGFARSSENSIDGTAARDVVAEFAFVLAQVGIDLSRLSEEIILWNTREFGFVTLSDSFSTGSSIMPQKKNPDIAELARGKSGRLIGNLSGLLATLKGLPLAYNRDLQEDKEPVFDSVQTLEVLLPAFTGMIATLRFDTDRMAELAPQGFSLATDVAEWLVKHRVAFRDAHEITGGLVKAAESRGVGLEDLTDDDLRAVSPHLVPEVREVLSIEGSVASRDGAGGTARVRVDEQRAELVRRVAELRARADAAAERRAAAAASASGEASE
>NZ_CP047054.1|WP_012038683.1|2274521_2275760_-|argininosuccinate-synthase
MAERVVLAYSGGLDTSVGIGWLKDATGKEVVALAVDVGQGGEDMEVIRQRALDCGAVEAVVVDAKDEFADDYIVPALKANALYQKRYPLVSGLSRPLIAKHLARVAHELGANSVAHGCTGKGNDQVRFEAAVAALAPDLTSIAPVRDLALTRDKAIVYANEHDLPIEQSKKSPYSIDKNVWGRAVETGFLEDPWNGPIEDLYEYTQDPDVLRDATEVTITFEAGVPVAIDGVRYSPLRIVQELNAAAGAHGIGRIDVVEDRLVGIKSREVYEAPAAMTLIEAHEELESLTIERDLGRYKRGVEKDWANLVYDGLWFSGLKRSLDAFIEDSQRHVSGDIRMTLRGGRAVVTGRRSESSLYDFDLATYDTGDTFDQSLSKGFIELWSLPSKISARRDLAVEQAALAADPAPAAE
>NZ_CP047054.1|WP_012038684.1|2275808_2276732_-|ornithine-carbamoyltransferase
MTRHFLRDDDLSPAEQAEVLDLAVQLKRERWSERPLAGPQTVAVIFDKSSTRTRVSFAVGIADLGGVPLIISTANSQLGGKETASDTARVLERQVAAIVWRTYGQAGLEEMAAGTTVPVVNALSDDFHPCQLLADLLTIREHRGDPAGQTLTFLGDGACNMAQSYLLAGATAGMHVRIAAPAGYVPSEAVVADAERIAASTGGSVRVLTDPVEAVSGADVVVTDTWVSMGREEEKAQRLAELGAYQVTTELMEHAVDDAIFLHCLPADREYEVASEVIDGPRSVVWDEAENRLHAQKALLVWLLRQS
>NZ_CP047054.1|WP_167604173.1|2276881_2278099_-|acetylornithine-transaminase
MTTTQPERRTTQTESEWSDRFQAAMMRSSPPPLAMLVRGEGCRVWDSTGREYLDFLAGIAVNSLGHAHPALIRAVTEQVSTLAHVSNYFATPPQIALAERLRRITGAGDTGRVYFGNSGAEANEAAFKLARRNGSAHRTRVITLQGSFHGRTMGALALTGQPALQAPFLPLPGGVEHIAPTLEALEAAIDDTVQALILEPIQGEAGVVDLPAGFLRRARELTREHGALLILDEIQTGVGRTGRWFAYEHEGVRPDAVTIAKGIAGGVPIGALVAFDAAADLLQKGQHGSTFGGNPLATAAGNAVLAEIEDAGLVENAARRGEEIRAAITGLDSPLIAEVRGRGLLIGVGLHHEDAGRIAAAALGEGLIINAPNARSLRIAPPLIVGDDEVRDFRERFGRALAHLR
>NZ_CP047054.1|WP_050976310.1|2278095_2279031_-|acetylglutamate-kinase
MGDADGTDVTAITQDAAERDQAQAESKAATLIESLSWLQRFHDRIVVVKFGGNAMVDEELTRTFAEDVVYLRYAGLRPVVVHGGGPQISAMLTRLGIESEFRGGYRVTTPEVLEVVRMVLTGQVSRDVVRGINAHGPLAAAVSGEDAGLFTGRRRGAVVDGVEVDLGLVGDVVAVDPTAVLAQLDAGRIPVVSSIAPDESDPAVSLNVNADAAAAALAVALGAEKLVILTDVAGLYRDWPDRGSLVSDIRSDELRALLPSLESGMIPKMAACLEAVDGGVPKAAIIDGRIPHSMLLEIFTTNGIGTEVVPA

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Crispr_ID: NZ_CP047054_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP047054_3

2352907-2353085

Orphan

Consensus_repeat	Method
CTTCGCCGTCGACTTCTTCGCGC	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP047054_3

>merge|NZ_CP047054|3|2352907-2353085|CRISPRCasFinder
CTTCGTGGTGGTCTTCTTCGCGCTCGCCTTCTTCGCCGTCGACTTCTTCGCGCTCGCCTTCTTCTCGGTCGTCGACTCCGCGCCCGAGGACTTCGCCGTCGACTTCTTCGCGGCGCCCTTCGTCGCGGTGCTCGCCTCGGCCCCGCTCGCCTTCTCCTTGGCGGCCGTCCTCTTCGCCG

>NZ_CP047054|3|2|2352907-2353085|CRISPRCasFinder
CTTCGTGGTGGTCTTCTTCGCGC	TCGCCTTCTTCGCCGTCGACTT
CTTCGCGCTCGCCTTCTTCTCGG	TCGTCGACTCCGCGCCCGAGGA
CTTCGCCGTCGACTTCTTCGCGG	CGCCCTTCGTCGCGGTGCTCGCCTCGGCCCCGCTCGCCTTCTC
CTTGGCGGCCGTCCTCTTCGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP047054.1\|WP_086507503.1\|2362064_2362586_+\|GtrA-family-protein	unknown	unknown	gnl\|CDD\|377229
NZ_CP047054.1\|WP_087196950.1\|2346518_2347904_-\|D-alanyl-D-alanine-carboxypeptidase	unknown	unknown	gnl\|CDD\|334815
NZ_CP047054.1\|WP_012038767.1\|2361128_2361875_-\|polyprenol-monophosphomannose-synthase	unknown	unknown	gnl\|CDD\|133062
NZ_CP047054.1\|WP_012038765.1\|2358637_2360155_-\|aspartate-ammonia-lyase	unknown	unknown	gnl\|CDD\|237031
NZ_CP047054.1\|WP_160444693.1\|2353947_2356467_+\|ATP-dependent-DNA-ligase	unknown	unknown	gnl\|CDD\|236599
NZ_CP047054.1\|WP_012038763.1\|2357464_2357602_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047054.1\|WP_160444694.1\|2351919_2352855_+\|DNA-3-methyladenine-glycosylase-2-family-protein	unknown	unknown	gnl\|CDD\|223200
NZ_CP047054.1\|WP_087196160.1\|2350439_2351861_-\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|273050
NZ_CP047054.1\|WP_012038769.1\|2362605_2363883_-\|Nramp-family-divalent-metal-transporter	unknown	unknown	gnl\|CDD\|334596
NZ_CP047054.1\|WP_012038755.1\|2348012_2348645_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|239737
NZ_CP047054.1\|WP_087198120.1\|2360261_2361113_+\|DUF429-domain-containing-protein	unknown	unknown	gnl\|CDD\|226778
NZ_CP047054.1\|WP_086506059.1\|2345818_2346481_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP047054.1\|WP_087196944.1\|2343488_2344286_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_CP047054.1\|WP_087196949.1\|2344574_2345822_+\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP047054.1\|WP_012038756.1\|2348746_2349025_-\|DUF3072-domain-containing-protein	unknown	unknown	gnl\|CDD\|371445
NZ_CP047054.1\|WP_079534592.1\|2363980_2365456_-\|NCS2-family-permease	unknown	unknown	gnl\|CDD\|225161
NZ_CP047054.1\|WP_104294356.1\|2349126_2350311_-\|PrsW-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|379143
NZ_CP047054.1\|WP_086507502.1\|2356557_2357436_+\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223257
NZ_CP047054.1\|WP_012038751.1\|2344285_2344495_+\|DUF2945-domain-containing-protein	unknown	unknown	gnl\|CDD\|378576
NZ_CP047054.1\|WP_086506065.1\|2357645_2358560_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366645

Protein	Function_ID	Function_description	E-value
NZ_CP047054.1\|WP_086507503.1\|2362064_2362586_+\|GtrA-family-protein	gnl\|CDD\|377229	pfam04138, GtrA, GtrA-like protein. Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.	3.05436e-17
NZ_CP047054.1\|WP_087196950.1\|2346518_2347904_-\|D-alanyl-D-alanine-carboxypeptidase	gnl\|CDD\|334815	pfam02113, Peptidase_S13, D-Ala-D-Ala carboxypeptidase 3 (S13) family.	7.23259e-39
NZ_CP047054.1\|WP_012038767.1\|2361128_2361875_-\|polyprenol-monophosphomannose-synthase	gnl\|CDD\|133062	cd06442, DPM1_like, DPM1_like represents putative enzymes similar to eukaryotic DPM1. Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.	1.90906e-90
NZ_CP047054.1\|WP_012038765.1\|2358637_2360155_-\|aspartate-ammonia-lyase	gnl\|CDD\|237031	PRK12273, aspA, aspartate ammonia-lyase; Provisional.	0
NZ_CP047054.1\|WP_160444693.1\|2353947_2356467_+\|ATP-dependent-DNA-ligase	gnl\|CDD\|236599	PRK09632, PRK09632, ATP-dependent DNA ligase; Reviewed.	0
NZ_CP047054.1\|WP_160444694.1\|2351919_2352855_+\|DNA-3-methyladenine-glycosylase-2-family-protein	gnl\|CDD\|223200	COG0122, AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair].	1.92633e-44
NZ_CP047054.1\|WP_087196160.1\|2350439_2351861_-\|FAD-binding-protein	gnl\|CDD\|273050	TIGR00387, Glycolate_oxidase_subunit_glcD., glycolate oxidase, subunit GlcD. This protein, the glycolate oxidase GlcD subunit, is similar in sequence to that of several D-lactate dehydrogenases, including that of E. coli. The glycolate oxidase has been found to have some D-lactate dehydrogenase activity. [Energy metabolism, Other].	2.69099e-111
NZ_CP047054.1\|WP_012038769.1\|2362605_2363883_-\|Nramp-family-divalent-metal-transporter	gnl\|CDD\|334596	pfam01566, Nramp, Natural resistance-associated macrophage protein. The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1, Nramp2, and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functional related proteins defined by a conserved hydrophobic core of ten transmembrane domains. This family of membrane proteins are divalent cation transporters. Nramp1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis. By controlling divalent cation concentrations Nramp1 may regulate the interphagosomal replication of bacteria. Mutations in Nramp1 may genetically predispose an individual to susceptibility to diseases including leprosy and tuberculosis conversely this might however provide protection form rheumatoid arthritis. Nramp2 is a multiple divalent cation transporter for Fe2+, Mn2+ and Zn2+ amongst others it is expressed at high levels in the intestine; and is major transferrin-independent iron uptake system in mammals. The yeast proteins Smf1 and Smf2 may also transport divalent cations.	7.2594e-26
NZ_CP047054.1\|WP_012038755.1\|2348012_2348645_-\|recombinase-family-protein	gnl\|CDD\|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	2.46816e-25
NZ_CP047054.1\|WP_087198120.1\|2360261_2361113_+\|DUF429-domain-containing-protein	gnl\|CDD\|226778	COG4328, COG4328, Predicted nuclease (RNAse H fold) [General function prediction only].	1.31304e-23
NZ_CP047054.1\|WP_086506059.1\|2345818_2346481_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	3.54565e-64
NZ_CP047054.1\|WP_087196944.1\|2343488_2344286_+\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.54065e-69
NZ_CP047054.1\|WP_087196949.1\|2344574_2345822_+\|two-component-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.15395e-18
NZ_CP047054.1\|WP_012038756.1\|2348746_2349025_-\|DUF3072-domain-containing-protein	gnl\|CDD\|371445	pfam11272, DUF3072, Protein of unknown function (DUF3072). This bacterial family of proteins has no known function.	3.35337e-19
NZ_CP047054.1\|WP_079534592.1\|2363980_2365456_-\|NCS2-family-permease	gnl\|CDD\|225161	COG2252, COG2252, Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism].	8.9218e-115
NZ_CP047054.1\|WP_104294356.1\|2349126_2350311_-\|PrsW-family-intramembrane-metalloprotease	gnl\|CDD\|379143	pfam13367, PrsW-protease, Protease prsW family. This is a family of putative peptidases, possibly belonging to the MEROPS M79 family. PrsW, appears to be a member of a widespread family of membrane proteins that includes at least one previously known protease. PrsW appears to be responsible for Site-1 cleavage of the RsiW anti-sigma factor, the cognate anti-sigma factor, and it senses antimicrobial peptides that damage the cell membrane and other agents that cause cell envelope stress, The three acidic residues, E75, E76 and E95 in Aflv_1074, appear to be crucial since their mutation to alanine renders the protein inactive. Based on predictions of the bioinformatics programme TMHMM it is likely that these residues are located on the extracytoplasmic face of PrsW placing them in a position to act as a sensor for cell envelope stress.	1.70289e-42
NZ_CP047054.1\|WP_086507502.1\|2356557_2357436_+\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	1.89663e-84
NZ_CP047054.1\|WP_012038751.1\|2344285_2344495_+\|DUF2945-domain-containing-protein	gnl\|CDD\|378576	pfam11160, DUF2945, Protein of unknown function (DUF2945). This family of proteins has no known function.	7.64326e-17
NZ_CP047054.1\|WP_086506065.1\|2357645_2358560_+\|hypothetical-protein	gnl\|CDD\|366645	pfam01442, Apolipoprotein, Apolipoprotein A1/A4/E domain. These proteins contain several 22 residue repeats which form a pair of alpha helices. This family includes: Apolipoprotein A-I. Apolipoprotein A-IV. Apolipoprotein E.	1.24312e-07

>NZ_CP047054.1|WP_160444694.1|2351919_2352855_+|DNA-3-methyladenine-glycosylase-2-family-protein
MDSPGAVAHVARTVLEVPGPFDGGGVIRFLSWHAVTGAEEGDATSFTQSARLAHGAGTVTVRLLEAEPGDVGGARVEVTTRVERAADAGELLAGTRRLLGLDVDAARIDADLARDPALAAVVRATPGLRIPGTLDPRSTLFRTIVGQQISVASARATHGRMTADLGEDLPASVAHGSVTRLPPTAARIARDGGELLRGPARRTATLIRIAEALETGELVIEPGVPRAELRAALVAFHGVGPWTADYVAMRALGEPDILLSGDLIVRRGGAALGLPDEARALDARAAAWSPWRSYATLHLWRVMTDGMPAAG
>NZ_CP047054.1|WP_087196160.1|2350439_2351861_-|FAD-binding-protein
MIDDDVVRTPPTPAAAVRAELVAALGDVVATDPASLDDARSDRSGYRSPADPIAVVRATEVDHVVQTLRIAHATRTPVVTRGAGTGLAGGATATAGEIVLSVRGMDRILEVSEADELAVVEPGVLNDDLNARLAPLGLWYSPDPASKAISTIGGNIATNAGGLLCAKYGVTREAVLALTVVLADGRVVDTGHRTVKGVTGYDLTALMIGSEGTLGVIVRATVRLRPLPTAIPSTVAAFFPDSTTAAAAASAITAARIRPAAMELLDAGALEAIDAFLGTDHSTRGSAHLLVRCDGPDAAEEAARVVEVVVAGGGTADVTDDAEEGERLLAIRRAFHPALAARGRVLIEDVAVPRSRLADMLARIRGIERETGLAIPTVAHAGDGNLHPNFCIPEDPTTPDGDATGIPDEVWRAADLLFRAAVDLGGTLTGEHGVGLLKRRWLADELGDDVMGLAAGIRRVFDPRGILNPGKAA
>NZ_CP047054.1|WP_104294356.1|2349126_2350311_-|PrsW-family-intramembrane-metalloprotease
MTVHRPSPASPPPSMELPAPHASSRITASAVLGVVGVAVLLLVGLVVAAYLVLSLGIQAVAICALLALIPLAGVLLAIRWVDRWEPEPRLALLFALLWGAAASVAIALLFDLVAQYARLAIGVPTRYTEFLQLAVQAPVVEESAKAIGLLLIFWVARRHFDGPVDGVVYGATIAAGFAFTENIVYFGGPLVSGTTGTLVGTFVLRGLFSPFAHVTFTMITGIAIGYGARRGPGAALGSGALGLVGAIVLHALWNTGVTITGDFLSFYVLLQVPIFAFLVTVVILLRRYEIHLTRRRLREYAAVGWFTPAEVEMLSTWQGRRRARLWARTRGGEAGRAMGLFTRDATRLAFARQRMLSERPAASGRSEAGHLDDERRLLRAVTEHREALLRGARG
>NZ_CP047054.1|WP_012038756.1|2348746_2349025_-|DUF3072-domain-containing-protein
MSDANQDTTGGDEKEMLGSSTPTPPQSAEKDPSTWVTGDEPMTGAQRSYLDSLATQAGEEIPADLNKAEASEQIERLQEKKDTASPQSDDAS
>NZ_CP047054.1|WP_012038755.1|2348012_2348645_-|recombinase-family-protein
MTTLVGYVRVARSEEPYQDQVDALDAAGCERIFVDVAGGRRAPRPGLQDALDYLRENDELLVVSLDRLGPGAADVVRILNGLEARGIAFRAIRDGLEAGTAAGRGLFAATLALATVEATTEAERHRKRSADRSAGSAPEGAPEAAPATPAAPALPSLPKGITRRKLQIAVEERSKGRDTAEIARVLDVSERVVTRALAWAESGRQGGMLR
>NZ_CP047054.1|WP_087196950.1|2346518_2347904_-|D-alanyl-D-alanine-carboxypeptidase
MTGSRPAPARRPPGRSRSVRRRRDAVLAAVVATAVVGVGLVTGILPSPAGGASADPASCTVDALTGGWSTGTLHLSAAEVDGDAGRALLDVRGDVPAATASTMKVLTAAAAVEGLGPDRRIATRVVQGARADTVVLVGGGDPTLSRLPSGTDGVYPDAPHLDDLARQVLDARRADPDLAGVPIRRLQVDSGLFTGPAWLPEWPLEARRGGSMSNITALMVDGDRDDPAEAYSRRGEKAVARAADAFAALLGDDVAADGPLVTAAPGSAVLGTVESAPVRDLVGYMLTHSDDTLAETLARLVAIETGAGSAAADIRSGTPAALADLDLPTDGVVLVDGSGLSDANRVPAALLTRLMVRVAEHRGDLAIVDAGLAVAGRTGTLAEGGRFTGEADAAAGRIRGKTGTLERMHGLTGIADAEDGTEVAFTIWAEDVDPSVPAESARAEIDALATDLHRCGGALGG
>NZ_CP047054.1|WP_086506059.1|2345818_2346481_+|response-regulator-transcription-factor
MIRIVLVDDQELFRGGVRVALDAQPDLEVVGEAGDGRQGLAVIDEVRPDVVLLDMRMPVMDGLETVRALFDGTRDAPPRVIVLTTFALDRASATAIRGGASGFLLKDATPAFLAAAIRAVHAGSAVLAPDELTQLFTSDATAAPAPPAPPAFRSLSAREKDVFGHVARGLSNAEVAALEFVSESTVKTHVSSILAKLALRDRVQVVVYAHDHRLVERAGS
>NZ_CP047054.1|WP_087196949.1|2344574_2345822_+|two-component-sensor-histidine-kinase
MDTGTAAVTRSTSTASPRRRSGAELAIDAIAGLLIAGLAVVPPVDVQEASLLVAALAFAAIIVRSVLPGTALVLAWAMALAQWQLGERPGFADVALLLVLYSTARRGSRPTAVLGAASALVGGSVATVYLLQTGARFSVLTQPGGPGGVIFAAAPVLALLLAWLTGLVVRVIRSRTAESRLRVQAEDTAVKAVDLAQAETLRASMARDVHDIVGHSLAVIIAQADSVQFLDDEERIRGVSATIADTARRSLAEVREVLSGTSTAEADDGPEDLDAVVAQVRAAGVDLAHEVRGVRRPVDPARQVVIRRVAQEMTTNAMRHGEPGGRIRLRETWRTADVVLEVENPVALRGPAPDHVDPLGLGALRVGTGVEGMRARLAAVGGDLEAEPVDDLFTARARIPLPAAHPIPTVPGGRP
>NZ_CP047054.1|WP_012038751.1|2344285_2344495_+|DUF2945-domain-containing-protein
MAGLKKGDHVTWNTPQGETHGKVVEEKTKDFQHDGQHFTASGDEPAYIVESDKSGKTAAHKGSALTKKK
>NZ_CP047054.1|WP_087196944.1|2343488_2344286_+|SDR-family-oxidoreductase
MDLGITGKTALITGADSGIGWETARILLAEGATVVLSDQDQGSLDEAAAKLDGGDRVHAFAADVTSVESLAALHDKVQEAVGDIDILVQSAGITGAQGLFHEIDDEGWTNTIEVDLMGPVRLVKRFLPSLRKGGWGRIVFLASEDAVQPYEDELPYCAAKAGILALSKGLSRSYAKEGLLVNAVSPAFIHTPMTDAMMEKRADQLGTSTDDAIESFLDEERPYMELKRRGEPTEVANVVAFLCSDLASFVNGSNYRVDSGSVATI
>NZ_CP047054.1|WP_160444693.1|2353947_2356467_+|ATP-dependent-DNA-ligase
MAGAKQQVEVDGHRIALTNLDKVLYPATGTTKGDVIAYYAAIAPHMLPHLRDRPVTRKRWVDGVGTDEAPGKMFFQKDLDAHTPEWVQRRAIQHRDHANDYPLVGDVATLTWLGQIAALELHVPQWRFGRTGDERRPDRLVLDLDPGPGAGLPECVEVAKAARAILRDMGLEPYPVTSGSKGIHLYAALDGRHDASRVSEVAHELARALEADHPDLVVSDMRKALRQGKVLVDWSQNNPNKTTVAPYSLRGRSRPTVAVPRTWRELSSPTLRHLELDEVIARMRRRADPLAPVEEGHRESLEPTRERLAGFERKEPADDADAADDRLATYRSKRDAAKTSEPVPAESPAPSEGSSFVIQEHHARALHWDFRLEHDGVLVSWALPKGVPTEHGTNHLAVQTEDHPLEYGSFEGTIPAGEYGGGEVTIWDAGTFELEKWRDGEEVIATLHGRGDGTGIDGPRRYALIHTGGHGKADANWLIHLMEPADAPATARAKPTRPASLEKAGGRTRVGARRKGGAASAPAPMLATAATAAGLDPDEEWAVEMKWDGYRAIAVVADGRATITSRNGVDLTPAFPELADLPDSLDVDAAVLDGEIVVLGDGGHPDFGLLQTRLGLTGEKEIARARKAAPVHLMLFDALAIGDRVLVEEPYRDRRAALLDAVRSPGRGRIQVPPAFDGDLDGALATSRELGLEGVVAKRVDAPYESGRRSSAWIKIKHHRAQEVVVGGWRPGSGSRASGIGSLLVGVPGPDGLEYAGRVGTGFTERDLADALRRFGPLARKTSPFADVPAADARDAHWITPRLVGEVEFAEWTSTGRLRQASWRGWRHDKSPDEVVRED
>NZ_CP047054.1|WP_086507502.1|2356557_2357436_+|fumarylacetoacetate-hydrolase-family-protein
MKFAHLLADDGVTPRLAAIVSEGEALFLDEVLDDSPRDLQDLIERGDDEMARVRATVERAVASRTSTTPVDGLTHASAILRPPAVYAVGLNYSAHAEELNITSASAPTVFALWPNSLSGHEGTTSWPRSLSEEVDYEVELGVIIGKAARDVSEADALDHVFGYTVVNDITARNLQFSEQQWSRCKSFDGFSPTGPVVVTRDEVPDPQDLRITTVLDGETVQDGRTSGMVRTVARLVSYLSTSSTLQPGTLISTGTTSGAGYSRDPQIFLKDGSTVTVSVEGIGSLTTHTRIL
>NZ_CP047054.1|WP_012038763.1|2357464_2357602_+|hypothetical-protein
MTDQQQDPIHDHSIPEDADVSAPDAVDPETDELHDATGRRGEKDA
>NZ_CP047054.1|WP_086506065.1|2357645_2358560_+|hypothetical-protein
MINRLLFLAGIGTGYVLGARAGRKRYEGIARTSRSVWSSEPVQRGVRQAQTVLDEKGPVVVERTVETAREVADFVGHAVQGAAVAVGRTAHTVGERIGTTTQDVAGRVGSTTQDIAGRVGDTAKDLGTRTADQTKHVVDRVGQQATEVGHRVAETAEDVRDRVVETAEEARTRVQATAEDLRERGEEAGRRAVFTAAEARDEALASFDDEDETGPVPIPRDGAPDEAPAPAEPVAAAPAPAPAKPKAAAKKPAPKPKAAPKASDAPHVPTPGDIAGSVHREEPAHAPADDATGTTPARTSGDEA
>NZ_CP047054.1|WP_012038765.1|2358637_2360155_-|aspartate-ammonia-lyase
MTPVSPNDDRIPTPDGHPVRTETDSLGSMDVPADAYWGIHTARALENFPISLRPLSVYPEFVVALAQVKQAAARANVQIGVLDARKAKQIDEVCTEIIAGQLHDQFVVGVIQGGAGTSTNMNTNEVIANRALERAGHALGDYRHMHPLDDVNRSQSTNDTYPTALKVALIHSLLQTLDELDLLRRSFLAKGAQFSQVLKVGRTQLQDAVPMTLGQEFHGFATTLGEDHARLGELVPLLSEINLGATAIGTGITADPNYAAAVRGHLSAITGYTLVTASDLIEATSDAGVFMTLSSTLKRSAIKLSKICNDLRLLSSGPQAGLGEINLPPRQAGSSIMPGKVNPVIPEVVNQVAFSIAGADVTVTMAAEGGQLQLNAFEPVIAHSLLQSLSWLRNAAKTLRVNCIDGITANTERLAAQVESSVGVVTALTPYIGYAASSSLAKTALMTSASIPDLVVEAGLMTRTQVEKILAPDRLSGLEPVTAAMSVITPEMLAAHAAEEGGQAD
>NZ_CP047054.1|WP_087198120.1|2360261_2361113_+|DUF429-domain-containing-protein
MRRFLGIDLAWAEGTATRPARETGLACIDAAGRVLDLATGRGIDEVVDWIARWDGPGAVAAVDGPLVVANATGSRLAEKEVASRYGRLGISAYPSNTGRPAQGAVALRRRLEDAGWEYDDGSASARDADARTMIECYPYTTLVGAPELGFDAMKPRYKRLAPLLATADRRPHRAAEFRMVLDAVAGLAHADPPLDVSTHPRAAALVADGPAIVERQHKHLEDLLDGLICAWTAAYWTRHGLARSQVLGATDPVVDERGRRGTIVAPARPHQRAPGDPLHAPEA
>NZ_CP047054.1|WP_012038767.1|2361128_2361875_-|polyprenol-monophosphomannose-synthase
MSSLTIVIPTYEEARNVGELLPRLAAMAAENPDFRITAMIVDDSSPDGTADLARSIAPSVETDAFRVRVETRAEKAGLGAAYIWAFERLLGADEPPTHILQMDADLSHDPSYITEMLRRVRGGADLVVASRYIRGGATPDWNLKRRFLSVGGNLYTRLFLGSRITDYTGGFNLYETELLRRITPSTITTTGYGFQIEMKQRALKLAERPTEVAIVFMDRTEGESKIPSDTLVKNLLLVLQLRFGLRRG
>NZ_CP047054.1|WP_086507503.1|2362064_2362586_+|GtrA-family-protein
MTRLLADRRVRFLIAGLLNTALDFVLLNALILAAHMPVLAANLISVTVGITISYFLNHFFVFRHGEAVTIGRFLKFFAVTGFSSLLLQSGVIWLFERGFDTTFGRSLLMFGTSAEQEFLEINIAKATAVLIGLVWNFTLYRLVVFRTPTPAAGAGADAAADGSPAVRQAASAD
>NZ_CP047054.1|WP_012038769.1|2362605_2363883_-|Nramp-family-divalent-metal-transporter
MTDLDTRGDVREPQESAKRWRIVGPGLVVAATGIGAGDLVATLVAGSRFGYALLWAAVLGVIIKIFLVEGAGRYSLATGKTIFEGWRTVGRWTTWYFGPYILIWGLVYGAAAMSSSALPLAALFPGVDLKVFAIACGLVGAVVVWFGRYSAFEKIIAVFVGLMFVTVVGAAIVTVPNVPALLTGLVPTIPEGGLVVALSIAGGVGGTITLAAYGYWLREKGWVAPRWMKVMRIDNSVAYVMSGIFVLSMLVVGAELLYSADIALADGEGGLVQLADVLGERYGAFMTWFFLLGFFATSFSSILGVWNGVSLMFADFLGTVRGLDVEDPRRRLGGSYYRAFIVWLTIPPIGLLFLDQPIGLIIAYGVLGALFMPFLAITLLVLLNTDRTPRAWRNRPLSNTVMGLSALLFVVLGVQQLVTEVGKLL
>NZ_CP047054.1|WP_079534592.1|2363980_2365456_-|NCS2-family-permease
MTEARTSSPAPETTDGRGALDRFFEITKRGSTYAREIRGGVLTFVTMAYIVVLNPLILGGFSADAATLDVEGNWLRASQVGAATALTAGVMTILFGLVARLPFAFAAGLGINSFLAVSVVGEVTWPEAMGLVVINGLVIVLLATTGLRTLIFRAVPRELKTAITVGIGLFIAFIGFVDSGFVRGTGVPASPLALGIDGSIASLPTVVFILGLVIMGVLMARRVPGALLIGIVATTLIAIVVEQVFHIGPSNTSGATGWNLNAPVLPGTPVALPDLGLVGAFDFGAFGRIGIISSLMLVFTLVFTNFFDAMGTMTGLAKAADLSDERGDFPRLKGALVVEGFGAVAGGATSSSSNTVFIESASGIGEGARTGLASMVTGVLFLLAMFFTPLTQVVPLEVAAAALVIVGTLMASQIRDIVWTDFSVALPVFLTVLVMPLTYSIANGIGVGFLSWVLVRSFSGRIREVSPLLWVVSAGFLIFFARGPIEQLLGV

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP047054_3	3.1\|2352930\|22\|NZ_CP047054\|CRISPRCasFinder	2352930-2352951	22	NC_008269	Rhodococcus jostii RHA1 plasmid pRHL1, complete sequence	122336-122357	2	0.909
NZ_CP047054_3	3.1\|2352930\|22\|NZ_CP047054\|CRISPRCasFinder	2352930-2352951	22	NC_008269	Rhodococcus jostii RHA1 plasmid pRHL1, complete sequence	387077-387098	2	0.909
NZ_CP047054_3	3.1\|2352930\|22\|NZ_CP047054\|CRISPRCasFinder	2352930-2352951	22	NZ_CP022567	Rhizobium leguminosarum bv. viciae strain BIHB 1148 plasmid pSK03, complete sequence	180166-180187	2	0.909
NZ_CP047054_3	3.2\|2352975\|22\|NZ_CP047054\|CRISPRCasFinder	2352975-2352996	22	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	217187-217208	2	0.909
NZ_CP047054_3	3.2\|2352975\|22\|NZ_CP047054\|CRISPRCasFinder	2352975-2352996	22	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	205311-205332	2	0.909
NZ_CP047054_3	3.2\|2352975\|22\|NZ_CP047054\|CRISPRCasFinder	2352975-2352996	22	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	206192-206213	2	0.909
NZ_CP047054_3	3.2\|2352975\|22\|NZ_CP047054\|CRISPRCasFinder	2352975-2352996	22	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	708322-708343	2	0.909
NZ_CP047054_3	3.2\|2352975\|22\|NZ_CP047054\|CRISPRCasFinder	2352975-2352996	22	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	1424058-1424079	2	0.909
NZ_CP047054_2	2.5\|2262829\|30\|NZ_CP047054\|PILER-CR	2262829-2262858	30	NZ_CP045296	Paenibacillus cellulositrophicus strain KACC 16577 plasmid unnamed1, complete sequence	15695-15724	6	0.8
NZ_CP047054_2	2.5\|2262829\|30\|NZ_CP047054\|PILER-CR	2262829-2262858	30	NZ_CP021767	Ralstonia solanacearum strain RS 489 plasmid unnamed, complete sequence	791839-791868	7	0.767
NZ_CP047054_2	2.5\|2262829\|30\|NZ_CP047054\|PILER-CR	2262829-2262858	30	NZ_CP026091	Ralstonia solanacearum strain IBSBF 2570 plasmid unnamed, complete sequence	1107823-1107852	8	0.733
NZ_CP047054_2	2.5\|2262829\|30\|NZ_CP047054\|PILER-CR	2262829-2262858	30	NZ_CP026093	Ralstonia solanacearum strain SFC plasmid unnamed, complete sequence	1107945-1107974	8	0.733
NZ_CP047054_2	2.7\|2262952\|33\|NZ_CP047054\|PILER-CR	2262952-2262984	33	NZ_CP029211	Aquabacterium olei strain NBRC 110486 plasmid pTB101, complete sequence	253635-253667	8	0.758
NZ_CP047054_2	2.7\|2262952\|33\|NZ_CP047054\|PILER-CR	2262952-2262984	33	NC_010604	Mycobacterium marinum M plasmid pMM23, complete sequence	4254-4286	9	0.727
NZ_CP047054_2	2.7\|2262952\|33\|NZ_CP047054\|PILER-CR	2262952-2262984	33	NC_017805	Deinococcus gobiensis I-0 plasmid P1, complete sequence	335075-335107	9	0.727
NZ_CP047054_2	2.7\|2262952\|33\|NZ_CP047054\|PILER-CR	2262952-2262984	33	NZ_CP034180	Mycobacteroides abscessus strain GZ002 plasmid pMabS_GZ002, complete sequence	12207-12239	9	0.727
NZ_CP047054_2	2.7\|2262952\|33\|NZ_CP047054\|PILER-CR	2262952-2262984	33	NC_010394	Mycobacterium abscessus plasmid, complete sequence	13954-13986	9	0.727
NZ_CP047054_2	2.4\|2262949\|37\|NZ_CP047054\|CRISPRCasFinder	2262949-2262985	37	NZ_CP029211	Aquabacterium olei strain NBRC 110486 plasmid pTB101, complete sequence	253634-253670	10	0.73
NZ_CP047054_2	2.2\|2262826\|34\|NZ_CP047054\|CRISPRCasFinder	2262826-2262859	34	NZ_CP021767	Ralstonia solanacearum strain RS 489 plasmid unnamed, complete sequence	791838-791871	11	0.676

1. spacer 3.1|2352930|22|NZ_CP047054|CRISPRCasFinder matches to NC_008269 (Rhodococcus jostii RHA1 plasmid pRHL1, complete sequence) position: , mismatch: 2, identity: 0.909

tcgccttcttcgccgtcgactt	CRISPR spacer
tcgccttcttcggcgtcgactg	Protospacer
************ ********

2. spacer 3.1|2352930|22|NZ_CP047054|CRISPRCasFinder matches to NC_008269 (Rhodococcus jostii RHA1 plasmid pRHL1, complete sequence) position: , mismatch: 2, identity: 0.909

tcgccttcttcgccgtcgactt	CRISPR spacer
tcgccttcttcggcgtcgactg	Protospacer
************ ********

3. spacer 3.1|2352930|22|NZ_CP047054|CRISPRCasFinder matches to NZ_CP022567 (Rhizobium leguminosarum bv. viciae strain BIHB 1148 plasmid pSK03, complete sequence) position: , mismatch: 2, identity: 0.909

tcgccttcttcgccgtcgactt	CRISPR spacer
tcgccttcatcgccgtcgactg	Protospacer
******** ************

4. spacer 3.2|2352975|22|NZ_CP047054|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 2, identity: 0.909

tcgtcgactccgcgcccgagga	CRISPR spacer
ccgtcgacaccgcgcccgagga	Protospacer
.******* *************

5. spacer 3.2|2352975|22|NZ_CP047054|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 2, identity: 0.909

tcgtcgactccgcgcccgagga	CRISPR spacer
ccgtcgacaccgcgcccgagga	Protospacer
.******* *************

6. spacer 3.2|2352975|22|NZ_CP047054|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 2, identity: 0.909

tcgtcgactccgcgcccgagga	CRISPR spacer
ccgtcgacaccgcgcccgagga	Protospacer
.******* *************

7. spacer 3.2|2352975|22|NZ_CP047054|CRISPRCasFinder matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 2, identity: 0.909

tcgtcgactccgcgcccgagga	CRISPR spacer
acgtcgactcctcgcccgagga	Protospacer
 ********** **********

8. spacer 3.2|2352975|22|NZ_CP047054|CRISPRCasFinder matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 2, identity: 0.909

tcgtcgactccgcgcccgagga	CRISPR spacer
acgtcgactcctcgcccgagga	Protospacer
 ********** **********

9. spacer 2.5|2262829|30|NZ_CP047054|PILER-CR matches to NZ_CP045296 (Paenibacillus cellulositrophicus strain KACC 16577 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.8

ctgcggccgggacgcccctccaccttcctt	CRISPR spacer
cggcatccgggacacccttccaccttcctc	Protospacer
* **. *******.***.***********.

10. spacer 2.5|2262829|30|NZ_CP047054|PILER-CR matches to NZ_CP021767 (Ralstonia solanacearum strain RS 489 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.767

ctgcggccgggacgcccctccaccttcctt	CRISPR spacer
gtgcggccggaacgccccgccacctcgccg	Protospacer
 *********.******* ******. *.

11. spacer 2.5|2262829|30|NZ_CP047054|PILER-CR matches to NZ_CP026091 (Ralstonia solanacearum strain IBSBF 2570 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

ctgcggccgggacgcccctccaccttcctt	CRISPR spacer
gcgcggccggaacgccccgccacctcgccg	Protospacer
 .********.******* ******. *.

12. spacer 2.5|2262829|30|NZ_CP047054|PILER-CR matches to NZ_CP026093 (Ralstonia solanacearum strain SFC plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

ctgcggccgggacgcccctccaccttcctt	CRISPR spacer
gcgcggccggaacgccccgccacctcgccg	Protospacer
 .********.******* ******. *.

13. spacer 2.7|2262952|33|NZ_CP047054|PILER-CR matches to NZ_CP029211 (Aquabacterium olei strain NBRC 110486 plasmid pTB101, complete sequence) position: , mismatch: 8, identity: 0.758

ctgcggccgacctgcggctccaccaccgtcctt	CRISPR spacer
ctgcggccgagctgcggcaccaccacttcagct	Protospacer
********** ******* *******. .  .*

14. spacer 2.7|2262952|33|NZ_CP047054|PILER-CR matches to NC_010604 (Mycobacterium marinum M plasmid pMM23, complete sequence) position: , mismatch: 9, identity: 0.727

ctgcggccgacctgcggctccaccaccgtcctt	CRISPR spacer
aggtggccgacctgcgccgccaccaccgcaccg	Protospacer
  *.************ * *********. *.

15. spacer 2.7|2262952|33|NZ_CP047054|PILER-CR matches to NC_017805 (Deinococcus gobiensis I-0 plasmid P1, complete sequence) position: , mismatch: 9, identity: 0.727

ctgcggccgacctgcggctccaccaccgtcctt	CRISPR spacer
ctgcggccgaccggcggctacacccagacccgc	Protospacer
************ ****** ****   ..** .

16. spacer 2.7|2262952|33|NZ_CP047054|PILER-CR matches to NZ_CP034180 (Mycobacteroides abscessus strain GZ002 plasmid pMabS_GZ002, complete sequence) position: , mismatch: 9, identity: 0.727

ctgcggccgacctgcggctccaccaccgtcctt	CRISPR spacer
aggtggccgacctgcgccgccaccaccgcaccg	Protospacer
  *.************ * *********. *.

17. spacer 2.7|2262952|33|NZ_CP047054|PILER-CR matches to NC_010394 (Mycobacterium abscessus plasmid, complete sequence) position: , mismatch: 9, identity: 0.727

ctgcggccgacctgcggctccaccaccgtcctt	CRISPR spacer
aggtggccgacctgcgccgccaccaccgcaccg	Protospacer
  *.************ * *********. *.

18. spacer 2.4|2262949|37|NZ_CP047054|CRISPRCasFinder matches to NZ_CP029211 (Aquabacterium olei strain NBRC 110486 plasmid pTB101, complete sequence) position: , mismatch: 10, identity: 0.73

acgctgcggccgacctgcggctccaccaccgtccttc	CRISPR spacer
tcgctgcggccgagctgcggcaccaccacttcagctt	Protospacer
 ************ ******* *******. .  .*.

19. spacer 2.2|2262826|34|NZ_CP047054|CRISPRCasFinder matches to NZ_CP021767 (Ralstonia solanacearum strain RS 489 plasmid unnamed, complete sequence) position: , mismatch: 11, identity: 0.676

acgctgcggccgggacgcccctccaccttccttc	CRISPR spacer
ggcgtgcggccggaacgccccgccacctcgccga	Protospacer
.   *********.******* ******. *.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

983724 : 993661

Pandoravirus(25.0%)

protease,tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_087197850.1\|983724_984258_+	O-acetyl-ADP-ribose deacetylase	F1SVT2	Red_sea_bream_iridovirus	3.7e-28	49.0
WP_087197852.1\|985065_986361_+	peptidoglycan DD-metalloendopeptidase family protein	G9BW84	Planktothrix_phage	1.0e-15	45.2
WP_086505198.1\|986374_987748_+	hypothetical protein	A0A0A8WIF2	Clostridium_phage	4.5e-09	40.0
WP_012037526.1\|987884_988412_-	inorganic diphosphatase	A0A1B1ISK6	uncultured_Mediterranean_phage	3.3e-29	44.4
WP_086505197.1\|988466_989492_+\|tRNA	tRNA lysidine(34) synthetase TilS	NA	NA	NA	NA
WP_087197171.1\|989493_990045_+	hypoxanthine phosphoribosyltransferase	A0A1V0SEQ1	Hokovirus	1.2e-08	30.8
WP_012037529.1\|990202_992203_+\|protease	ATP-dependent zinc metalloprotease FtsH	E5EQ50	Micromonas_sp._RCC1109_virus	1.3e-105	45.6
WP_012037530.1\|992207_992792_+	GTP cyclohydrolase I	A0A0B5J000	Pandoravirus	8.5e-26	40.1
WP_050976350.1\|992818_993661_+	dihydropteroate synthase	S4VNV0	Pandoravirus	1.8e-24	35.4

DBSCAN-SWA_2

1179630 : 1186527

Escherichia_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_087198027.1\|1179630_1180770_-	glycosyltransferase family 4 protein	J7Q7I8	Aeropyrum_coil-shaped_virus	2.5e-05	28.6
WP_012037693.1\|1180861_1181608_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	4.0e-12	27.4
WP_012037694.1\|1181591_1182461_-	ABC transporter permease	NA	NA	NA	NA
WP_087198029.1\|1182555_1183410_-	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	3.5e-28	37.3
WP_012037696.1\|1183406_1184396_-	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	6.4e-74	42.2
WP_012037697.1\|1184576_1185029_+	GtrA family protein	NA	NA	NA	NA
WP_012037698.1\|1185054_1185660_+	dTDP-4-dehydrorhamnose 3,5-epimerase family protein	A0A1D7XFA9	Escherichia_phage	3.7e-24	35.4
WP_086505675.1\|1185663_1186527_+	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	2.8e-94	59.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP047054

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection