CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP050993	Chryseobacterium sp. NEB161 chromosome, complete genome	8 crisprs	WYL,cas3,RT,PrimPol,DEDDh,PD-DExK,cas2,cas1,cas9	4	13	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP050993_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050993_1

257663-257754

Unclear

Consensus_repeat	Method
TTCAAAAAGAGGATTGCAGATGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050993_1

>merge|NZ_CP050993|1|257663-257754|CRISPRCasFinder
TTCAAAAAGAGGATTGCAGATGCGGAAAAACGTGCCAGGGAAACGGAAAAGATGCTCAATTCGCCGGAGTTCAAAAAGAGGATTGCTGATGC

>NZ_CP050993|1|1|257663-257754|CRISPRCasFinder
TTCAAAAAGAGGATTGCAGATGC	GGAAAAACGTGCCAGGGAAACGGAAAAGATGCTCAATTCGCCGGAG
TTCAAAAAGAGGATTGCTGATGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050993.1\|WP_076783477.1\|264210_265209_-\|DNA-topoisomerase-IB	unknown	unknown	gnl\|CDD\|226099
NZ_CP050993.1\|WP_076783478.1\|266403_266712_+\|DUF3098-domain-containing-protein	unknown	unknown	gnl\|CDD\|378629
NZ_CP050993.1\|WP_076783474.1\|260279_260651_-\|large-conductance-mechanosensitive-channel-protein-MscL	unknown	unknown	gnl\|CDD\|376605
NZ_CP050993.1\|WP_168637457.1\|253739_254501_-\|peroxide-stress-protein-YaaA	unknown	unknown	gnl\|CDD\|377151
NZ_CP050993.1\|WP_168637450.1\|244798_245890_+\|redox-regulated-ATPase-YchF	unknown	unknown	gnl\|CDD\|236583
NZ_CP050993.1\|WP_168637462.1\|262550_264083_+\|DASS-family-sodium-coupled-anion-symporter	unknown	unknown	gnl\|CDD\|279307
NZ_CP050993.1\|WP_168637454.1\|249319_251902_+\|DNA-gyrase/topoisomerase-IV-subunit-A	unknown	unknown	gnl\|CDD\|237192
NZ_CP050993.1\|WP_076783470.1\|254676_255288_-\|threonylcarbamoyl-AMP-synthase	unknown	unknown	gnl\|CDD\|272879
NZ_CP050993.1\|WP_168637453.1\|248819_249320_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_076783479.1\|266787_267606_+\|undecaprenyl-diphosphate-phosphatase	unknown	unknown	gnl\|CDD\|234712
NZ_CP050993.1\|WP_168637451.1\|245988_246765_+\|TIGR00266-family-protein	unknown	unknown	gnl\|CDD\|376704
NZ_CP050993.1\|WP_168637455.1\|251947_252589_+\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|366759
NZ_CP050993.1\|WP_076783490.1\|265501_266401_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|225088
NZ_CP050993.1\|WP_076783471.1\|256013_256373_+\|BlaI/MecI/CopY-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367747
NZ_CP050993.1\|WP_168637452.1\|246922_248818_+\|type-IIA-DNA-topoisomerase-subunit-B	unknown	unknown	gnl\|CDD\|235501
NZ_CP050993.1\|WP_168637460.1\|259383_260232_+\|GLPGLI-family-protein	unknown	unknown	gnl\|CDD\|273495
NZ_CP050993.1\|WP_168637459.1\|258518_259358_+\|GLPGLI-family-protein	unknown	unknown	gnl\|CDD\|273495
NZ_CP050993.1\|WP_168637463.1\|267778_268483_+\|tRNA-pseudouridine(55)-synthase-TruB	unknown	unknown	gnl\|CDD\|211339
NZ_CP050993.1\|WP_168637456.1\|252775_253675_-\|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	unknown	unknown	gnl\|CDD\|236467
NZ_CP050993.1\|WP_168637461.1\|260765_262256_+\|NAD(P)H-hydrate-dehydratase	unknown	unknown	gnl\|CDD\|238576

Protein	Function_ID	Function_description	E-value
NZ_CP050993.1\|WP_076783477.1\|264210_265209_-\|DNA-topoisomerase-IB	gnl\|CDD\|226099	COG3569, COG3569, Topoisomerase IB [DNA replication, recombination, and repair].	8.8967e-75
NZ_CP050993.1\|WP_076783478.1\|266403_266712_+\|DUF3098-domain-containing-protein	gnl\|CDD\|378629	pfam11297, DUF3098, Protein of unknown function (DUF3098). This bacterial family of proteins has no known function.	1.45117e-26
NZ_CP050993.1\|WP_076783474.1\|260279_260651_-\|large-conductance-mechanosensitive-channel-protein-MscL	gnl\|CDD\|376605	pfam01741, MscL, Large-conductance mechanosensitive channel, MscL.	1.06139e-45
NZ_CP050993.1\|WP_168637457.1\|253739_254501_-\|peroxide-stress-protein-YaaA	gnl\|CDD\|377151	pfam03883, H2O2_YaaD, Peroxide stress protein YaaA. YaaA is a key element of the stress response to H2O2. It acts by reducing the level of intracellular iron levels after peroxide stress, thereby attenuating the Fenton reaction and the DNA damage that this would cause. The molecular mechanism of action is not known.	8.75764e-101
NZ_CP050993.1\|WP_168637450.1\|244798_245890_+\|redox-regulated-ATPase-YchF	gnl\|CDD\|236583	PRK09601, PRK09601, redox-regulated ATPase YchF.	0
NZ_CP050993.1\|WP_076783479.1\|266787_267606_+\|undecaprenyl-diphosphate-phosphatase	gnl\|CDD\|234712	PRK00281, PRK00281, undecaprenyl-diphosphate phosphatase.	5.34625e-83
NZ_CP050993.1\|WP_168637454.1\|249319_251902_+\|DNA-gyrase/topoisomerase-IV-subunit-A	gnl\|CDD\|237192	PRK12758, PRK12758, DNA gyrase/topoisomerase IV subunit A.	0
NZ_CP050993.1\|WP_168637462.1\|262550_264083_+\|DASS-family-sodium-coupled-anion-symporter	gnl\|CDD\|279307	pfam00939, Na_sulph_symp, Sodium:sulfate symporter transmembrane region. There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.	1.87118e-128
NZ_CP050993.1\|WP_076783470.1\|254676_255288_-\|threonylcarbamoyl-AMP-synthase	gnl\|CDD\|272879	TIGR00057, Putative_threonylcarbamoyl-AMP_synthase, tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family. Has paralogs, but YrdC called a tRNA modification protein. Ref 2 authors say probably heteromultimeric complex. Paralogs may mean its does the final binding to the tRNA. [Protein synthesis, tRNA and rRNA base modification].	1.92686e-56
NZ_CP050993.1\|WP_168637451.1\|245988_246765_+\|TIGR00266-family-protein	gnl\|CDD\|376704	pfam01987, AIM24, Mitochondrial biogenesis AIM24. In eukaryotes, this domain is involved in mitochondrial biogenesis. Its function in prokaryotes in unknown.	1.74659e-84
NZ_CP050993.1\|WP_168637455.1\|251947_252589_+\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|366759	pfam01694, Rhomboid, Rhomboid family. This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.	3.06358e-17
NZ_CP050993.1\|WP_076783490.1\|265501_266401_+\|ABC-transporter-permease	gnl\|CDD\|225088	COG2177, FtsX, Cell division protein [Cell division and chromosome partitioning].	1.3161e-39
NZ_CP050993.1\|WP_076783471.1\|256013_256373_+\|BlaI/MecI/CopY-family-transcriptional-regulator	gnl\|CDD\|367747	pfam03965, Penicillinase_R, Penicillinase repressor. The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.	2.25933e-25
NZ_CP050993.1\|WP_168637452.1\|246922_248818_+\|type-IIA-DNA-topoisomerase-subunit-B	gnl\|CDD\|235501	PRK05559, PRK05559, DNA topoisomerase IV subunit B; Reviewed.	0
NZ_CP050993.1\|WP_168637460.1\|259383_260232_+\|GLPGLI-family-protein	gnl\|CDD\|273495	TIGR01200, conserved_hypothetical_protein, GLPGLI family protein. This protein family was first noted as a paralogous set in Porphyromonas gingivalis, but it is more widely distributed among the Bacteroidetes. The protein family is now renamed GLPGLI after its best-conserved motif.	4.38657e-44
NZ_CP050993.1\|WP_168637459.1\|258518_259358_+\|GLPGLI-family-protein	gnl\|CDD\|273495	TIGR01200, conserved_hypothetical_protein, GLPGLI family protein. This protein family was first noted as a paralogous set in Porphyromonas gingivalis, but it is more widely distributed among the Bacteroidetes. The protein family is now renamed GLPGLI after its best-conserved motif.	8.86158e-46
NZ_CP050993.1\|WP_168637463.1\|267778_268483_+\|tRNA-pseudouridine(55)-synthase-TruB	gnl\|CDD\|211339	cd02573, PseudoU_synth_EcTruB, Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). E. coli TruB and M. tuberculosis TruB make psi55 in the T loop of tRNAs. Psi55 is nearly universally conserved. E. coli TruB is not inhibited by RNA containing 5-fluorouridine.	1.82686e-95
NZ_CP050993.1\|WP_168637456.1\|252775_253675_-\|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	gnl\|CDD\|236467	PRK09328, PRK09328, N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional.	2.68904e-79
NZ_CP050993.1\|WP_168637461.1\|260765_262256_+\|NAD(P)H-hydrate-dehydratase	gnl\|CDD\|238576	cd01171, YXKO-related, B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.	9.07011e-85

>NZ_CP050993.1|WP_076783471.1|256013_256373_+|BlaI/MecI/CopY-family-transcriptional-regulator
MNKLTKAEEQVMQYLWQIEKGFLKDVLELFPEPKPHTNTISTILKILMEKGFVNYKTFGRQHEYFPIVSKESYSGRSIRSLVKNYFEGSYTNAVSFLVEENEISVQDLELLLNELKNKE
>NZ_CP050993.1|WP_076783470.1|254676_255288_-|threonylcarbamoyl-AMP-synthase
MAKILKIYPQNPQENLIDEAVKVLQNGGVIIYPSDTIYTIGCDIYNHKAMERLAQIKGIKLDKHQFSIICNDLSHLSEFTKPIETSTFRFLKNHLPGAFTFILEANRNLPTTYKGRKTVGIRVPDHIVPQMLVEKLGHPIVSTSIHDDDEILEYSTDPELIAEKYDKLVDIVIDSGYGDNNASTIVDLTTGEPEIIRQGKGIL
>NZ_CP050993.1|WP_168637457.1|253739_254501_-|peroxide-stress-protein-YaaA
MKFITSPAKLMNVENSTELLKTTTPKFIKDAELIQSFLKGKSPKFLAELMEISPKLADENWERNQKWSAKPTAKNSAPAMFAFTGEVYRGLDAKTLDEKAVKYLEKNYRILSGLYGLLKPSDKIMLYRLEMGRPFQFDTFKNLYAFWTEKVTDQLNSELKKNELLINLASNEYGKVIDRKKLKTKVVDFDFKQIQPDGKLKTIVVYTKHARGLMLRFCAENQVETLDELKAFNYENYLLDEKLSSETKLVFTR
>NZ_CP050993.1|WP_168637456.1|252775_253675_-|peptide-chain-release-factor-N(5)-glutamine-methyltransferase
MKLSEIKLLFQKELSELYSKSEIEELFVIFCGHFLELNKIDLRQNLEKGLAESDSNQFYDAISELKTGKPFQQILGETEFFGMKFFVNDQVLIPRPETEELLELATNKIQESRKKNQERLGEPQPGNQQPTTNKHFRILDIGTGSGIIPIILKKYFPEAEVTSIDISRDALEMAKKNADFHQTEISFIQKDYLNEKLDDVYDIIISNPPYIGIEENVEIEDSVKGFEPNLALFSPTSDALIFYRKISEDAEKHLAENGLIFLEINQKLGKETLELYSQFAYSELLKDISGNDRIIYVKK
>NZ_CP050993.1|WP_168637455.1|251947_252589_+|rhomboid-family-intramembrane-serine-protease
MNIVLIIIIAITCITSYIGFQKPEVFQKYKFEVGAIQRRKEYIRLLSAGFLHGDWMHLFFNMLTLYFFAPIAIYGFGVVGFLIIYIASIILGNLFCLIVYKNVPFYSAIGASGGVSGVLFAAVALAPKEIEVNFLPGYLFGALYFGYSVYMMLNPRAHDNIGHAAHLGGAFFGLVYAVAVYPQVAMQNAVYLGVMALPLIYLAYQIFVNKRIG
>NZ_CP050993.1|WP_168637454.1|249319_251902_+|DNA-gyrase/topoisomerase-IV-subunit-A
MEESTHNEESLKKVSGLYKDWFLDYASYVILDRAIPSIFDGFKPVQRRIMHSMRELEDGRYNKVANIVGNTMKYHPHGDASITDAMVQLGQKELLIDTQGNWGNIYTGDSAAAARYIEARLTPFALDVVFNPKTTHWTKSYDGRNNEPVDLPVKFPLLLAQGVEGIGVGLSTKIMPHNFNELIAASILYLKGKKFELYPDFLTGGMLDVAGYNDGKRGGKIRARARISQKEKHTLTITELPFSKNTGDLIDSILKANERGKIKIKKIEDNTSDNVEINIHLHPDVSPDKTIDALYAFTDCEVPISPNACVIVGDKPMFLSVSEILKHNTDHTVSLLKKELEIELHELQESWHFSSLERIFIENRIYHDIEEVISWEDVISTIDEGLKPHTAHLLRAVTEEDIVRLTEIRIKRISRFDLDKFKENILALEGKIEQVKHHLVHLIPYAIDYYTNIQKKYGKGKERRTELRIFDTIDATKVAVANEKFYVNREEGFIGTSLKKDEYLFDCSDIDDIITFQKDGTMKVVKVEGKTFIGKNIVHVAIWKKNDKRTVYNMIYREGREGPFYMKRFSVTGVTRNTDYKLASDKKGSEMLYFSANPNGEAELVSVLLKPNARVRKNKIDIDFSELAIKGRDSKGNLVTKYAVKKVDLKEEGVSTLAPRKIWFDDSVRRLNADGRGTLLGSFKGDDKILTINSQGEAKLVSFDLMNRFDDDYLILQKWNPEQPITCIYFDGEKDKYFVKRFLLEATPNIQIFFGNENPKSFIEFVTTDAGAKAEIIFPKIKDRQKDPEIVDLDEFITVKGIKAIGNQLTKDKVKTINITIPEPPEIVEEEIEIDIRPADESDEEGGTIGNLFDENTESI
>NZ_CP050993.1|WP_168637453.1|248819_249320_+|hypothetical-protein
MRLSNREKKPFYSFIYSLGGIIFLLGLIAYILEISKFDVFGSRSWILLIIPLVLFAFLYLMGRPIFEYDSDGEALNFRNSHILYLLAKKDARDEFPKYKIIKYNIISVLFFKRLYVYILSKKNQVIILKYEISYLNRKQIEDLKFSLNKVVKYNSENRKQDNTVTD
>NZ_CP050993.1|WP_168637452.1|246922_248818_+|type-IIA-DNA-topoisomerase-subunit-B
MSEVNSANYSEDNIRTLEPREHVRLRPGMYIGKLGDGSSVDDGIYILLKEVLDNSIDEFRMKAGKRIDVKIKDGTVTVRDYGRGIPLGKIVDVVSIMNTGGKYDDGAFKKSIGLNGVGTKAVNFLSTYFRVKSVREGRMRIAEFREGRLDILHDEAETTERNGTEITFVPDNSIFVNFKFRNEYVEKMLRNYTYLNLSLKIYFNGEVFESQNGLKDLLEEEIDGEIVYPIIHIKDEDMELAITHSDKSQSETYFSFVNGQYTSQGGTHLSAFKEAYVKTIREFFNKNFEATDIRKAIIAAVYINVGNPVFESQTKTKLGSTTMGQDKDGKELETIKTFVINYLKSKLDNYLHKNPEIAEAIHKKILISERERKELSGIQKLARERAKKVSLHNKKLRDCRHHYNDQKAARKSETMIFITEGDSASGSITKSRDVETQAVFSLKGKPLNCYGLTKKIVYENEEFNLLQAALNIEESLEDLRYNQVIIATDADVDGMHIRLLMITFFLQFFPDLIKNGHLYILQTPLFRVRNKKETRYCYSDAERLKALNELGKNPEITRFKGLGEISPDEFKHFIGKDIRLEPVVVGRDQTIDQLLEFYMGKNTQDRQLFILDNLVVEDDSEIDKKKTLESA
>NZ_CP050993.1|WP_168637451.1|245988_246765_+|TIGR00266-family-protein
MKNHEIDFKIYGEELQCVEIELDPNEAVIAEPGSFMMMNDGIRMETMFGDGSNSGLMNKLFTAGRRMLTGESLFMTVFTNISSQKRQVSFAAPYTGKIIPLNLSDYGEKIICQKDSFLCAAKGVSIGIEFQRKLGTGLFGGEGFIMQKLEGDGMCFVHSGGYVMEKELQHGEILKIDTGCIVAFTQSVSYDIQFIGGIENTLFGGEGLFFAELRGPGKVWVQTLPISRLAGKILQYGSGSRREEGSILGKLGDIIDGN
>NZ_CP050993.1|WP_168637450.1|244798_245890_+|redox-regulated-ATPase-YchF
MKCGIVGLPNVGKSTLFNCLSNAKAQSANYPFCTIEPNLGTVSVPDTRLFELEKLVNPERVLPAVVEIVDIAGLVKGASKGEGLGNQFLANIRECEAIIHVLRCFDNGNIVHVEGSVDPLRDKEIIDIELQLKDLETIGKAVDKAKKFIKSGKKEDILAYETLQNLQKFVEDGKNAREFPVDDFTKSIIDDVQLLTKKPVLYVCNVDENSIKNGNSWIGEIEEMAQKESAEVVVLAAQIEADINELETFEERQMFLEELGLEEPGVNRLIRKAYDLLKLQTYFTAGVKEVRAWTIGQGWTAPQAAGVIHTDFEKGFIRAEVIAYDDFVNYGSEAKVKEAGKMRVEGKEYIVKDGDIMHFRFNV
>NZ_CP050993.1|WP_168637459.1|258518_259358_+|GLPGLI-family-protein
MNKLFTIYFIMLCTLMFGQNKRFIYEYQLIPDSANVADVKKEMMYLDTSKDGSKYYSYTVFNSDSLMKADIERQVKANGTINITAPMKAGSVRYSVTKTYPDYKVNLHRRLGMDAYNISEDRKINWKIASDKEKIGEWNAQKAEADFAGRHWIAWFSTDIPIQDGPYKFYGLPGLIVKIEDKTGSHKMELRGIKNINSNLDINVFNAKEVSVNQKQFQKVVADYENDPTKGIRQIQMGGTTVIMTGKDSNSVKFAKEQEERLKNQIKKDNNRIELDIVK
>NZ_CP050993.1|WP_168637460.1|259383_260232_+|GLPGLI-family-protein
MRQIILLTVVLRSAFLFSQNQRFYYDYTFQTDSTDADTEKSELMVLDINKKGSQYYSEYVFQNDSIMDAQFKKNRAAHNNDVIAMSGKQGVVGYKILKTYPDFKINHIVTLDMTPYNASQQVKFDWKILPEKTKIGNWNVQKAETDFAGRHWIAWFSAEIPIQDGPYKFYGLPGLIVKIEDRSGSHLMELKGIKNNVIERDLFSFASKKPVAIDYKKYQSAYKAYRKDPLANFKKKTLAGEIYMTDESGNRLNGADYIKSQEKLMSERMKKNNNVLEIDLLK
>NZ_CP050993.1|WP_076783474.1|260279_260651_-|large-conductance-mechanosensitive-channel-protein-MscL
MGFVKEFKEFAFKGNVVDLAVGVIIGGAFGAIVKSLVDDVITPLLLTPALKAAGAENIKELSWNGVTYGNFLSSVISFLVIAFVLFWLIKLANKVTKKPEEAPAGPSSTDALLMEIRDELKKK
>NZ_CP050993.1|WP_168637461.1|260765_262256_+|NAD(P)H-hydrate-dehydratase
MKILSAPQIKECDQTTIRTGISSIQLMEKAANACASWIVNNMKNIKKVQVFCGKGNNGGDGFAVARLLYEKAIDVEVYIDRGKQDFSEDAKINYKKIRKNSGIVFKYFSEFLPDNNENSLIIDALFGYGLNRNLSGRVKAVVDQLNSSRQPKLAIDIPSGLYADKMTDDNSTVFKADITLTFQFYKRSFMHPETGRFCGTIELLDIGLDLQFIDDAKTDFFVADRQMIRSIYRPRADFSNKGTFGKSILVGGSYGKMGSVLMSTLAALRTGSGLTFTMAPDCGYGILQSQVPEAMFVNSGDNYIDKLEIQEKSVYGIGPGLGKEKLTQQALFDFLKSYKNPVVLDADALNILAESKKQNLIPKNSVITPHPLEFGRLFGKTHDSFERLDLAKKKAKEHQIFIVLKDHHTAVVTPQGQVFYNITGNSGMAKGGSGDVLTGILTSLISQKYEPESACILGVWLHGMAGDLAAEQFSKEAMLPTDLIHKIADVFKLLSK
>NZ_CP050993.1|WP_168637462.1|262550_264083_+|DASS-family-sodium-coupled-anion-symporter
MKDFQQEVKEKFYLHFNLVPAILSLVSFVLVLLIPKPDALSQGAWTMLAIFVASIVAIIGKASSVGVVSLFGIALVAIFKATAPHLDANGAALPVTSKMAIQDALASYSNELIWLIVIAIMISRGIIKTRLGERIGYYFISVFGKKTLGIGYALALCETLLAPLTPSNTARGGAIIHPIMRSIALAFNSKPEDGTQNRIGRYLALVNYHANPISSAMFLTATAPNPLVMEYVNKVAGTSLHITWSTWALTMLVPGLVAMFLMPLVIFFLAKPEVTETPNATSFAKDKIKELGPLSLNEKLMLGIFALLLILWADVPAMLFGNMFIVNPTTTAIIGLFLLIITGILDWDEILGQKSAWDTLFWFGALVMMADQLNKHGIISWFSDNFQVWLLSMHLGSLLVFAILVCVFFYSHYFFASTTAHISAMMLAFLIVGSQTIEPGLRVPFYLMMMAAGSLMMCLTHYATGTSPIIFGSGYVTMGSWWGIGFVMSIVNLIVFAVVGAVWWKILGLY
>NZ_CP050993.1|WP_076783477.1|264210_265209_-|DNA-topoisomerase-IB
MKITRRASGKNFVYLDKNKDRLKDPETIDYIKSLVIPPAWKDVEITTNKRAKILAYGRDQKGRKQYIYNPRFRARKDADKFDRILHFAENLEHMRRVTGQHLRKKKMSREKVLAAMVRLLDSAYFRPGSPKYTQQNKSYGLTTIRKKHLTIEGDEMIFSYKGKSGKFQEKHVINSKLSKVIKQLEALPGYRLFKYYDENDALIFVESQDLNQYIKEVMGEEFSAKDFRTWAGTMIAAGILDELGICEKKQQKELKIRVRNAIVAVSEKLGNTPSVARDSYIDPRIFEHYKNGHTIHYFQKEIKKLLKKNENLSETEVGVLYMLKSKLKTSKS
>NZ_CP050993.1|WP_076783490.1|265501_266401_+|ABC-transporter-permease
MPKTVDDFNKSRLRSSNITVVISISLVLFLVGLFGLILINAQKYSDYIKEQLVVEAYFDEYLDPRDSAKTLKFQEETFAKIKEQNYVKQARYISKQQATVLAKKQLGIDANALFEEDIFPASVEVTLKPEFVDPAKIDGVVSQLKAIPGVKDVANDNQLTIDVYNNLNRILTWILAFSILFLIVAIVLINNSIRLKIFSKRFIIKTMQLVGAKRRFILKPFIKEALILGLIGAFIGLAALGGVWYYFTSQIGTPFVQDTNQYIVLIFIILFVGIFITVASTIFATWRFLRSNVDDLYYS
>NZ_CP050993.1|WP_076783478.1|266403_266712_+|DUF3098-domain-containing-protein
MAKKTTNKFSADQFGKPTKTEEKKAFYFGNKNFKLMLIGLGLILLGFVLMMGSDANTTPDGKFDPNYWNEAIFSFRRIRLAPILVIAGFIIQVVAILKRNKD
>NZ_CP050993.1|WP_076783479.1|266787_267606_+|undecaprenyl-diphosphate-phosphatase
MDLIKAIIIAIVEGLTEYLPISSTAHMGFTASLMGLEETEFLKMFQVSIQFGAILSVVVAYWKKFFDFSNFQFYIKLAFAVLPALIIGFFLDDKIEAVLGNQIAISSVLVLGGIVLLFADNWFKNPVIHDEKEITIKKAITIGFWQCLAMMPGTSRSAASIIGGMTQGLSRKAAAEFSFFLAVPTMLAVTLYSVFVKTWGKETPNPQKGYEMILASQDHILIFIVGNLVAFIVAWIAIKSFIALLNKYGFRPWGWYRIFVGLALLIYFYWFK
>NZ_CP050993.1|WP_168637463.1|267778_268483_+|tRNA-pseudouridine(55)-synthase-TruB
MTAEDLQSGYVFLLDKPLDWTSFQAVNKLKYKLKREFRELPKKFKIGHAGTLDPRATGLLIVCTGKFTKKIPEIQDAPKEYWTEIKIGVQTESYDTEKPEILPTDFSHITEGQIHQALEKFLGEIDQKPPIFSAIKIDGNRAYDLARKGEEVEMKTRKTTIHYINDIEINLPFISFTVGCSKGTYIRSLAHDIGQELGVGAYLTQLRRTKIGDYSVENATQDYLDNDYHFSENL

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Crispr_ID: NZ_CP050993_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050993_2

1183177-1183288

Orphan

Consensus_repeat	Method
CAGGAGTTCAAATCCGAAAACATTGAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050993_2

>merge|NZ_CP050993|2|1183177-1183288|CRISPRCasFinder
CAGGAGTTCAAATCCGAAAACATTGAAAATATCTACCTCGTTTTAACATTTCTTTAACTCCTTGGAGTGCAATTCCGAATTCAGCAGGAGTTCAAATCCGAAAACTTTGAAA

>NZ_CP050993|2|2|1183177-1183288|CRISPRCasFinder
CAGGAGTTCAAATCCGAAAACATTGAAA	ATATCTACCTCGTTTTAACATTTCTTTAACTCCTTGGAGTGCAATTCCGAATTCAG
CAGGAGTTCAAATCCGAAAACTTTGAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050993.1\|WP_076784279.1\|1176069_1176579_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_076784278.1\|1176696_1177026_-\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238042
NZ_CP050993.1\|WP_168638078.1\|1190882_1191239_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378935
NZ_CP050993.1\|WP_168638070.1\|1180653_1181532_+\|IS982-family-transposase	unknown	unknown	gnl\|CDD\|376573
NZ_CP050993.1\|WP_168638075.1\|1187140_1187785_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274153
NZ_CP050993.1\|WP_168638068.1\|1175566_1176079_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
NZ_CP050993.1\|WP_124986562.1\|1181745_1183059_-\|IS1380-family-transposase	unknown	unknown	gnl\|CDD\|379340
NZ_CP050993.1\|WP_168638069.1\|1178755_1179946_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379871
NZ_CP050993.1\|WP_168638074.1\|1185532_1186666_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271185
NZ_CP050993.1\|WP_168638066.1\|1173896_1174928_-\|ACR3-family-arsenite-efflux-transporter	unknown	unknown	gnl\|CDD\|213563
NZ_CP050993.1\|WP_159435880.1\|1180016_1180463_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|273804
NZ_CP050993.1\|WP_168638065.1\|1173419_1173800_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168638076.1\|1189213_1190602_-\|DUF3987-domain-containing-protein	unknown	unknown	gnl\|CDD\|379041
NZ_CP050993.1\|WP_168638080.1\|1192285_1193428_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271185
NZ_CP050993.1\|WP_168638072.1\|1184388_1184676_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378935
NZ_CP050993.1\|WP_168638073.1\|1184764_1185529_-\|folate/biopterin-family-MFS-transporter	unknown	unknown	gnl\|CDD\|341037
NZ_CP050993.1\|WP_168638071.1\|1183290_1184382_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168638077.1\|1190605_1190893_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168638067.1\|1174931_1175543_-\|protein-tyrosine-phosphatase	unknown	unknown	gnl\|CDD\|319973
NZ_CP050993.1\|WP_168638079.1\|1191348_1192263_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP050993.1\|WP_076784278.1\|1176696_1177026_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.71002e-15
NZ_CP050993.1\|WP_168638078.1\|1190882_1191239_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	3.98323e-13
NZ_CP050993.1\|WP_168638070.1\|1180653_1181532_+\|IS982-family-transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	1.47906e-14
NZ_CP050993.1\|WP_168638075.1\|1187140_1187785_-\|hypothetical-protein	gnl\|CDD\|274153	TIGR02479, RNA_polymerase_sigma_factor_WhiG, RNA polymerase sigma factor, FliA/WhiG family. Most members of this family are the flagellar operon sigma factor FliA, controlling transcription of bacterial flagellar genes by RNA polymerase. An exception is the sigma factor WhiG in the genus Streptomyces, involved in the production of sporulating aerial mycelium.	0.00928637
NZ_CP050993.1\|WP_168638068.1\|1175566_1176079_-\|N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	1.51249e-45
NZ_CP050993.1\|WP_168638073.1\|1184764_1185529_-\|folate/biopterin-family-MFS-transporter	gnl\|CDD\|341037	cd17484, MFS_FBT, Folate-biopterin transporter of the Major Facilitator Superfamily of transporters. The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	0.000937995
NZ_CP050993.1\|WP_168638069.1\|1178755_1179946_-\|hypothetical-protein	gnl\|CDD\|379871	pfam16670, PI-PLC-C1, Phosphoinositide phospholipase C, Ca2+-dependent. PI-PLC-C1 is a family of calcium 2+-dependent phosphatidylinositol-specific phospholipase C1 enzymes from bacteria and fungi. The enzyme classification number is EC:3.1.4.11. This enzyme is involved in part of the myo-inositol phosphate metabolic pathway.	3.93586e-144
NZ_CP050993.1\|WP_168638074.1\|1185532_1186666_-\|site-specific-integrase	gnl\|CDD\|271185	cd01185, INTN1_C_like, Integrase IntN1 of Bacteroides mobilizable transposon NBU1 and similar proteins, C-terminal catalytic domain. IntN1 is a tyrosine recombinase for the integration and excision of Bacteroides mobilizable transposon NBU1 from the host chromosome. IntN1 does not require strict homology between the recombining sites seen with other tyrosine recombinases. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	1.28847e-43
NZ_CP050993.1\|WP_168638066.1\|1173896_1174928_-\|ACR3-family-arsenite-efflux-transporter	gnl\|CDD\|213563	TIGR00832, Uncharacterized_transporter_slr0944, arsenical-resistance protein. The Arsenical Resistance-3 (ACR3) Family (TC 2.A.59) The first protein of the ACR3 family functionally characterized was the ACR3 protein of Saccharomyces cerevisiae. It is present in the yeast plasma membrane and pumps arsenite out of the cell in response to the pmf. Similar proteins are found in bacteria, often as part of a four gene operon with an regulatory protein ArsR, a protein of unknown function ArsH, and an arsenate reductase that converts arsenate to arsenite to facilitate transport. [Cellular processes, Detoxification, Transport and binding proteins, Anions].	1.2856e-142
NZ_CP050993.1\|WP_159435880.1\|1180016_1180463_-\|TonB-dependent-receptor	gnl\|CDD\|273804	TIGR01782, TonB-dependent_receptor, TonB-dependent receptor. This model represents a family of TonB-dependent outer-membrane receptors which are found mainly in Xanthomonas and Caulobacter. These appear to represent the expansion of a paralogous family in that the 22 X. axonopodis (21 in X. campestris) and 18 C. crescentus sequences are more closely related to each other than any of the many TonB-dependent receptors found in other species. In fact, the Crescentus and Xanthomonas sequences are inseparable on a phylogenetic tree using a PAM-weighted neighbor-joining method, indicating that one of the two genuses may have acquired this set of receptors from the other. The mechanism by which this family is shared between Xanthomonas, a gamma proteobacterial plant pathogen and Caulobacter, an alpha proteobacterial aquatic organism is unclear. [Transport and binding proteins, Porins].	5.20761e-25
NZ_CP050993.1\|WP_168638076.1\|1189213_1190602_-\|DUF3987-domain-containing-protein	gnl\|CDD\|379041	pfam13148, DUF3987, Protein of unknown function (DUF3987). A family of uncharacterized proteins found by clustering human gut metagenomic sequences.	2.09024e-64
NZ_CP050993.1\|WP_168638080.1\|1192285_1193428_-\|site-specific-integrase	gnl\|CDD\|271185	cd01185, INTN1_C_like, Integrase IntN1 of Bacteroides mobilizable transposon NBU1 and similar proteins, C-terminal catalytic domain. IntN1 is a tyrosine recombinase for the integration and excision of Bacteroides mobilizable transposon NBU1 from the host chromosome. IntN1 does not require strict homology between the recombining sites seen with other tyrosine recombinases. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	3.22337e-46
NZ_CP050993.1\|WP_168638072.1\|1184388_1184676_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	2.52896e-07
NZ_CP050993.1\|WP_124986562.1\|1181745_1183059_-\|IS1380-family-transposase	gnl\|CDD\|379340	pfam13701, DDE_Tnp_1_4, Transposase DDE domain group 1. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	6.87863e-37
NZ_CP050993.1\|WP_168638067.1\|1174931_1175543_-\|protein-tyrosine-phosphatase	gnl\|CDD\|319973	cd16345, LMWP_ArsC, Arsenate reductase of the LMWP family. Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).	2.77876e-08

>NZ_CP050993.1|WP_124986562.1|1181745_1183059_-|IS1380-family-transposase
MKFDLSFTNKEITPWGGMVFLKQMLDKIGFREQIEKCESLPVSLSNNSYKKEVLLESFITSIWCGANRFLHTEITRADKALGEIFDWRKTPAQDAYKRYFGKFTQHINQQVGHHFFSWFFQNLNLNYFTLDIDSSVITRYGEQEGAKKGYNPKKKGRNSHHPIIAFVNDVKMVANFWLRSGDTSSANNFVGFLEETLLNFGDKKVGLVRLDSGFFQKDIMDYLELKTLQYIIAAKFTHPIQHLIDQQDFWIKVDEGIEICDKYYQAKNWEKPRRIVIVRQKTAQRPNAAGRILSLFPEDEIHRNYRYSAYITNQEQSATDVWRTYRNRGDAENRIKELKADFGAESFNLKGFFPTEAALIFSMIAYNLMSIFRLFVLQEKTQKTLSTLRYRTFAIGAYFEKVGDTLKLKIALTKKRRKWFVGIWDYPIDLSQKISTA
>NZ_CP050993.1|WP_168638070.1|1180653_1181532_+|IS982-family-transposase
MNNLIQNYKIILKELTNTCKYITTSKQIRLPKMSDLELVALNLTAEYMSINSELQLFRCISGTDLEGRIERSVYNKRKRKLFPYIEKIRETLSSKFSDFTDVFIVDSTPIEICKISRANRSAICSTDEIKPAYGYCAAQKSRYFGYKLHAVCDKNGIFHSFDFSPANVHDVNYLHDIKENFENCLLIGDRGYISKEYQLDLFNYSKINLSVPMRKNQHDFVEFSKTKSKIRKRIETNISQLCGQFLININLAKTFQGLATRIVSKITSFTMIQYLDFFVFKRSLNKLKINLC
>NZ_CP050993.1|WP_159435880.1|1180016_1180463_-|TonB-dependent-receptor
MFGLEANISKRFTALPGFLQYFGIEGNYTYVDSGTKIPVYTNGVEASTIDSSLPKQAKHIFNISLFYETNQLMIRVAGNYKGNYLNAIRSLAGPDHYQWFDKNFTLDATASYAFSKKVRAFIEMNNIFNEPNRFYHGTQARTESISYT
>NZ_CP050993.1|WP_168638069.1|1178755_1179946_-|hypothetical-protein
MAVLMPFSFFTQTKKEFSNYPKGLKINQIQVLGTHNSYAKPVDPKVLKMASDIFNQYKGSFLDKMPADEKAKFQEYHPNGMDFTEALNYNHPDFDEQLNAGLRNLEIDVYYDPTGNRFTKPASYELLKKQGITDLYPFSTDGMDQPGFKVLHIADIDFRTHYTTLKKALTALKTWSDAHPKHIPVYIQIEAKDMAIPIFPNSSQVLPFDSKAYEDLDQEILSILGRQKIITPDDVKGNYKSLNQAVLHQNWPTVNASLGKFIFVLLPGSAGMKSGESAYLEGHPQLEGRMMFLHSEPGKDYAAFLLYDNAIVRQNEIRKAVKEGYLVRSRSDIETYEAKVNNPARKEAAFRSGAQIISTDFFRPGNTYGTPYFVELPGGETARCNPINAPADCKVK
>NZ_CP050993.1|WP_076784278.1|1176696_1177026_-|winged-helix-turn-helix-transcriptional-regulator
MGLTRSDIFSDEQNKLASLFKVLGHPARIAILQYIINQKACICNDLVDELGLAQATISQHLKELKNIGIIKGTIEGKSVCYCIEEKKWKEVQGLFNQFFEQEVKVNQCC
>NZ_CP050993.1|WP_076784279.1|1176069_1176579_-|hypothetical-protein
MKLSNIKEILPALDNVEFQLEDGTFVPEHFHVTEVGVITKHFIDCGGTIRNEKVVNFQLWNANDFEHRLKPAKLLNIIKLSEEKLGIEDAEIEVEYQSAIADSQTPNQTINGLQTIGKYDLDFNGNHFILKNKQTACLAQDACGIPFEKQKVKLSDLNNACCTPNSGCC
>NZ_CP050993.1|WP_168638068.1|1175566_1176079_-|N-acetyltransferase
MLLNTVTMEIRPITKDNFSEAVEIYKQGLATNIATFQNDLPQWEDWNKGHLDFCRISIYENNKMLGWTALTPVSSRCVYAGVAEVSVYIAQKERGKGIGKILLNELITQSEANGIWMLQSGIFSENQSSIKLHEKCGFRMVGYREKIGKKNGIWKDNILMEYRSKNIGID
>NZ_CP050993.1|WP_168638067.1|1174931_1175543_-|protein-tyrosine-phosphatase
MYPTLSKTIEQLPLQNISEERKTILQPLIDFIQQKVNDRQDININFICTHNSRRSHLSQVWAQAASAHFNIPNVYCYSGGTEETALFPKVAETLSNQGFNIFKINDGTNPLYAIKYSDNSQPIIGFSKKYDSPFNPVSAFAAIMTCSQADGGCPFIAGAEKRIPITFEDPKISDNRSEQSQVYAERSLQIATEMFYVFSKISQ
>NZ_CP050993.1|WP_168638066.1|1173896_1174928_-|ACR3-family-arsenite-efflux-transporter
MQPKLKFLDRYLTLWIFLAMAVGIGLGYFFPGISKITNALSVGTTNIPLAIGLILMMYPPLAKVDYSLLPQAFKDKKVIGISLLLNWIIGTVLMFGLAVLFLRDEPDYMTGLILIGLARCIAMVIVWSDLAKANREYTAMLVALNSVFQVLSYSFLVWLFINVLPNKLGLANFNVTVSMKDVTESVLIYLGIPFLAGFISRYTLVKSKGIEWYNRKFVPRISPITLYALLFTIVLMFSLKGDKIVELPIDVVKVAIPLIIYFVLMFFVSFFINKSLKVPYDKNASIAFTATGNNFELAIAVAIAVFGIHSPQAFVGVIGPLVEVPVLILLVRASLWLKKKYYY
>NZ_CP050993.1|WP_168638065.1|1173419_1173800_-|hypothetical-protein
MKKWFAIILLSFYLCSTTELYQFLKIPILVEHYFEHKSENPEMTVFAFLKMHYDNPVKDADWQTDQKLPFITHHEHSIIVFILNPLFSLEINENQQPIRSRKIIAYNDAVLDSDIINAVWQPPKFC
>NZ_CP050993.1|WP_168638071.1|1183290_1184382_-|hypothetical-protein
MNPIFDDKKIRKRYNWDDSNVDFIRFPNELLDDFLMDAGKFVDIPINALRVIFNIIFIVRNDQFRPEDRPRQLSLFEEEFETENNVFVQLSIKNARISPSGSTLTVIKAYEFLTKFKMEWHKALNSKGEEIKTFGGLISNPSYNKRGETTFLISRYWLRKIVVISEYNPLLYNLVYNVKNNKHILFALWLKKIPFQGTSILLTTFNKKFDLNYANSGDFCTKFLSEVRKSLNQYSDLSFNYKYSRQLIFILPYLTKKIVDLSISEETTVLIRIKQRLRYFKSRFEIEDHHFLKFENEYYKFPFHRELIEKAYRELKMSCRKKRLAVTIYKGKMFLEEMQRILIEFYQVSESGRKFPNGFPVIV
>NZ_CP050993.1|WP_168638072.1|1184388_1184676_-|helix-turn-helix-domain-containing-protein
MATIENELILHKLNRIEKHIFGLKSILNVEELAEYTGFKKSYIYKLVHENLIPFSKPNGKVLFFERKKIDEFLLQNASKSKDEISKEALEFSLKK
>NZ_CP050993.1|WP_168638073.1|1184764_1185529_-|folate/biopterin-family-MFS-transporter
MNETLNYVLVIYLWVAIGTQIGFIFYYYIKFFYEFLGGNKISWNSKYDRLLLTGSIFFLLLSIFLYSHLLDNNSYYNAALYIIVITLLSLLTVIMLKNGIKESKNNDLAKSEIVNKTIQEKEYSFKLNYSKIELMQIYHKMVDNSFIEILIKNPHMNDNDYFVDILFNGKLPEQTFFKLNFDNIQTKTFWDHLKSREIGLKQEKKMSREKFAKIFENNNGKIKVNSLSASKSKATSEAKKIEIINSLFDFIKKG
>NZ_CP050993.1|WP_168638074.1|1185532_1186666_-|site-specific-integrase
MKISLNKRKLKDGRISLSIEYYRGSEVNSEGKRRHLRSFENLDTYLFSEPKTPAEKKHNKEGLSFAESVLAIKKAEYVQGKFDLKNTTKSKRTFLAFFSELTDEKMKQDSSNNYGNWFSTLQHLKKIVSPSFTFDEVDENFIKRVKNYFEKEALTKSNLPLSQNSKYSYFNKFKASLRRAFDDGYLTINYASKVKSFEQAESQREYLTFDELQSLAKSECKYPILKSAFMFSCLSGLRWSDVNTLIWSEVRDEGDFSKVNFRQEKTDGVEYLYISAQARELLGERKDPEDRVFRGLKYGMTYNTELVRWCNRAGVAKHITFHSARHTNAVLLLENGIDIYTVSKRLGHREIRTTAIYAKIVDKKMKEAAEMIPNIIL
>NZ_CP050993.1|WP_168638075.1|1187140_1187785_-|hypothetical-protein
MTKKDLQKFTDFETKFEKLLSKNQIEIEDLKVFESDEQTQLNERFVGLLEEKKDIDFDELIYKLDKVMPESTKNQIWERNHNTITATISELMQDYGRMPTVTEIANKSAISRQTITKHLKDYVNNPLYRAKKEQFKFMTDKVLAKVFRFAVNGDIAAAKLYFNVMGCLNNGSNKTIQNNNFIQINNTILKQETVEQLEPEQIKEIEAIVLKNRN
>NZ_CP050993.1|WP_168638076.1|1189213_1190602_-|DUF3987-domain-containing-protein
MSNKINPKFEDLRNPEIIQQHINELTKVCASGFPVEVFPEAIQEVIKATNETLLYPIDFIGSAILYAISVATGNTHTVEVKKGWRETCAIYISIVGRPGTSKTHPISYALKPIHNTDSENFKEYQLKYKQYDKIKKLSQKERDAKGIDEPDKPIWKQHLVSDFTPEALTDTHKVNLRGIGVYVDELASWFNNFNRYNNGSEEQFWLSVWSGATIRINRKTSEPTFIQKPFISVMGTIQPGVLNELANNRKDNGFLDRLLFVVPDNLKKEYWNDKELEDRITDNWDAIISKLTQIKVLQTENGSVQPDVLTFTHESKRILSDYQRTLTDRSNSAPDAEAAIYAKIEVYAIRLALILEMSFYACDESNKKNIGTKAVEGAIKLCEFFLENAFNVHSILNGNSNKYENLPQIKQDVYDNLPDIFTTQEGWQIAEKFGMKERTYQRFIKEKELFNEVKHGEYSKKL
>NZ_CP050993.1|WP_168638077.1|1190605_1190893_-|hypothetical-protein
MESKLNNPKFFKGQGKDKKISGQMTKVFNAFSTQPKTMKMVSRQTGIDRANICRYVAEWKEQNSIQEVRKGLCRITKHRAGYLTTDPTLFNNVNS
>NZ_CP050993.1|WP_168638078.1|1190882_1191239_-|helix-turn-helix-domain-containing-protein
MEALTFEQLPTAVTLLTKEVSELKALLLKNSDQQPSQPQDELLTIQQASELLNLSVPTLYSKVSKGELPVMKRSKRLYFSRTELIDYLKAGKKKTFAELEAEADAYLSNNKKGLNNGI
>NZ_CP050993.1|WP_168638079.1|1191348_1192263_-|hypothetical-protein
MEKLNLITEFDEFYKGSDLQKIVSHKPLPIKYTIDGFDFYFYNADLFGLFEWNIKKDGLTTSDFIDDYKKGFEAGLLHLKTSEEIELKDLKSKDLREGTISQLKYILHEREFQFGSKGLLDLVFNKLPLIFTKKIIFDYGYWNGIIYSIDKISEKAGLSPNELKALPPQQMEVKNSNIKPTITINSEAKETVFSILKDFFETEQQDEFKEVLATFGTVKNKLIFKSYSNQFTDTFKKLFENNFILGCQKTDLINWIVSNFNFMYRKEVKEFKTKTVEQIISGNQTPCKSPIIEIKNGQILKIDY
>NZ_CP050993.1|WP_168638080.1|1192285_1193428_-|site-specific-integrase
MGIKVSLRQKTISDNRKSLYLDFYPAVYNSESGKETRREFLKMYIYENPKGKAEKDHNKNTLVTAEAIRQKRQNYFDKPEVYSEFEKEVLKQKKKDELNFVEYFEKLANKRKASNYDNWISALNYLKNFTNGHLKFADLSEIFLEEFKEYLLTTKANKRTKATLSQNSAVSYFNKVKATLKQAYKDGILKQDLNAKIEPIKAAETRREYLTINELNELVKTPCNNPLLKNAALFSALTGLRFSDIQKMVWSEIVFIEGQGYFLNFSQKKTKGIETLPISDQAVSLCGERRDPADKVFDGLEYSAYSNKHLAQWIGAAGITKEITFHCFRHTFATLQLFNGTDIYTVSKMLGHKDLKTTQVYAKIVDDAKRTAANKIKLEL

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Crispr_ID: NZ_CP050993_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050993_3

1627790-1627921

Orphan

Consensus_repeat	Method
TTCTTCGAGAGCCTCAGACTGACA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP050993_3

>merge|NZ_CP050993|3|1627790-1627921|CRISPRCasFinder
GTCTTCGAGAGCCTCAGACTGACATTTCTTCGAGAGCCTCAGACTGACATCTTTTTGAGAGCCTCAGGCTAACAATATTAATACTAAAATTGAAACTTCAAATTAGAATTCTTCGAGAGCCTCAGACTGACA

>NZ_CP050993|3|3|1627790-1627921|CRISPRCasFinder
GTCTTCGAGAGCCTCAGACTGACA	TTTCTTCGAGAGCCTCAGACTGACAT
CTTTTTGAGAGCCTCAGGCTAACA	ATATTAATACTAAAATTGAAACTTCAAATTAGAA
TTCTTCGAGAGCCTCAGACTGACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050993.1\|WP_168638417.1\|1619332_1620121_+\|aminotransferase-class-I-and-II	unknown	unknown	unknown
NZ_CP050993.1\|WP_168638430.1\|1640036_1641116_-\|ketoacyl-ACP-synthase-III	unknown	unknown	gnl\|CDD\|238426
NZ_CP050993.1\|WP_168638423.1\|1627993_1630801_+\|M1-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341067
NZ_CP050993.1\|WP_168638416.1\|1616629_1618957_-\|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|275036
NZ_CP050993.1\|WP_168638421.1\|1623095_1624637_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP050993.1\|WP_168638424.1\|1630853_1631636_-\|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|275036
NZ_CP050993.1\|WP_168638426.1\|1635868_1636696_-\|sulfurtransferase	unknown	unknown	gnl\|CDD\|225450
NZ_CP050993.1\|WP_168638425.1\|1631720_1632425_-\|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|275036
NZ_CP050993.1\|WP_168638420.1\|1621682_1622726_-\|bifunctional-transcriptional-activator/DNA-repair-protein-Ada	unknown	unknown	gnl\|CDD\|223427
NZ_CP050993.1\|WP_168638431.1\|1641274_1641871_+\|YigZ-family-protein	unknown	unknown	gnl\|CDD\|376491
NZ_CP050993.1\|WP_168638422.1\|1625919_1627278_+\|orotate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223537
NZ_CP050993.1\|WP_168638418.1\|1620098_1620482_+\|DUF3037-domain-containing-protein	unknown	unknown	gnl\|CDD\|378608
NZ_CP050993.1\|WP_168639687.1\|1632613_1635820_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_159435858.1\|1615545_1615851_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378935
NZ_CP050993.1\|WP_168638419.1\|1621024_1621558_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NZ_CP050993.1\|WP_076783158.1\|1627430_1627727_-\|GIY-YIG-nuclease-family-protein	unknown	unknown	gnl\|CDD\|198403
NZ_CP050993.1\|WP_168638428.1\|1637937_1638690_+\|polysaccharide-deacetylase	unknown	unknown	gnl\|CDD\|200566
NZ_CP050993.1\|WP_168638429.1\|1638742_1639948_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277331
NZ_CP050993.1\|WP_076783156.1\|1624887_1625439_+\|DNA-3-methyladenine-glycosylase	unknown	unknown	gnl\|CDD\|225374
NZ_CP050993.1\|WP_168638427.1\|1636888_1637857_+\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187580

Protein	Function_ID	Function_description	E-value
NZ_CP050993.1\|WP_168638430.1\|1640036_1641116_-\|ketoacyl-ACP-synthase-III	gnl\|CDD\|238426	cd00830, KAS_III, Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP. KASIII initiates this process by specifically using acetyl-CoA over acyl-CoA.	1.23535e-80
NZ_CP050993.1\|WP_168638423.1\|1627993_1630801_+\|M1-family-metallopeptidase	gnl\|CDD\|341067	cd09604, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains bacterial M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	2.2195e-06
NZ_CP050993.1\|WP_168638416.1\|1616629_1618957_-\|T9SS-type-A-sorting-domain-containing-protein	gnl\|CDD\|275036	TIGR04183, hypothetical_protein, Por secretion system C-terminal sorting domain. Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber average twenty or more copies of a C-terminal domain, represented by this model, associated with sorting to the outer membrane and covalent modification.	4.72717e-09
NZ_CP050993.1\|WP_168638421.1\|1623095_1624637_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.29721e-62
NZ_CP050993.1\|WP_168638424.1\|1630853_1631636_-\|T9SS-type-A-sorting-domain-containing-protein	gnl\|CDD\|275036	TIGR04183, hypothetical_protein, Por secretion system C-terminal sorting domain. Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber average twenty or more copies of a C-terminal domain, represented by this model, associated with sorting to the outer membrane and covalent modification.	1.92118e-08
NZ_CP050993.1\|WP_168638426.1\|1635868_1636696_-\|sulfurtransferase	gnl\|CDD\|225450	COG2897, SseA, Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism].	2.66684e-81
NZ_CP050993.1\|WP_168638425.1\|1631720_1632425_-\|T9SS-type-A-sorting-domain-containing-protein	gnl\|CDD\|275036	TIGR04183, hypothetical_protein, Por secretion system C-terminal sorting domain. Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber average twenty or more copies of a C-terminal domain, represented by this model, associated with sorting to the outer membrane and covalent modification.	5.8961e-09
NZ_CP050993.1\|WP_168638420.1\|1621682_1622726_-\|bifunctional-transcriptional-activator/DNA-repair-protein-Ada	gnl\|CDD\|223427	COG0350, Ada, Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	5.56726e-64
NZ_CP050993.1\|WP_168638431.1\|1641274_1641871_+\|YigZ-family-protein	gnl\|CDD\|376491	pfam01205, UPF0029, Uncharacterized protein family UPF0029.	7.61257e-52
NZ_CP050993.1\|WP_168638422.1\|1625919_1627278_+\|orotate-phosphoribosyltransferase	gnl\|CDD\|223537	COG0461, PyrE, Orotate phosphoribosyltransferase [Nucleotide transport and metabolism].	2.20541e-61
NZ_CP050993.1\|WP_168638418.1\|1620098_1620482_+\|DUF3037-domain-containing-protein	gnl\|CDD\|378608	pfam11236, DUF3037, Protein of unknown function (DUF3037). This bacterial family of proteins has no known function.	8.83344e-55
NZ_CP050993.1\|WP_159435858.1\|1615545_1615851_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	2.10499e-08
NZ_CP050993.1\|WP_168638419.1\|1621024_1621558_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	4.87152e-22
NZ_CP050993.1\|WP_076783158.1\|1627430_1627727_-\|GIY-YIG-nuclease-family-protein	gnl\|CDD\|198403	cd10456, GIY-YIG_UPF0213, The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1. This family contains a group of uncharacterized proteins found mainly in bacteria and several in dsDNA viruses. Although their function roles have not been recognized, these proteins show significant sequence similarities with the N-terminal GIY-YIG endonuclease domain of structure-specific endonuclease subunit SLX1, which binds another structure-specific endonuclease subunit SLX4 to form an active heterodimeric SLX1-SLX4 complex. This complex functions as a 5' flap endonuclease in yeast, and has also been identified as a Holliday junction resolvase in human.	1.11397e-26
NZ_CP050993.1\|WP_168638428.1\|1637937_1638690_+\|polysaccharide-deacetylase	gnl\|CDD\|200566	cd10941, CE4_PuuE_HpPgdA_like_2, Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA). This family contains many uncharacterized prokaryotic polysaccharide deacetylases (DCAs) that show high sequence similarity to the catalytic domain of bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA). PuuE allantoinase appears to be metal-independent and specifically catalyzes the hydrolysis of (S)-allantoin into allantoic acid. Different from PuuE allantoinase, HpPgdA has the ability to bind a metal ion at the active site and is responsible for a peptidoglycan modification that counteracts the host immune response. Both PuuE allantoinase and HpPgdA function as homotetramers. The monomer is composed of a 7-stranded barrel with detectable sequence similarity to the 6-stranded barrel NodB homology domain of DCA-like proteins in the CE4 superfamily, which removes N-linked or O-linked acetyl groups from cell wall polysaccharides. In contrast to typical NodB-like DCAs, PuuE allantoinase and HpPgdA do not exhibit a solvent-accessible polysaccharide binding groove and might only bind a small molecule at the active site.	5.90878e-15
NZ_CP050993.1\|WP_168638429.1\|1638742_1639948_-\|metallophosphoesterase	gnl\|CDD\|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	3.41147e-52
NZ_CP050993.1\|WP_076783156.1\|1624887_1625439_+\|DNA-3-methyladenine-glycosylase	gnl\|CDD\|225374	COG2818, Tag, 3-methyladenine DNA glycosylase [DNA replication, recombination, and repair].	6.08163e-53
NZ_CP050993.1\|WP_168638427.1\|1636888_1637857_+\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187580	cd05272, TDH_SDR_e, L-threonine dehydrogenase, extended (e) SDRs. This subgroup contains members identified as L-threonine dehydrogenase (TDH). TDH catalyzes the zinc-dependent formation of 2-amino-3-ketobutyrate from L-threonine via NAD(H)-dependent oxidation. This group is distinct from TDHs that are members of the medium chain dehydrogenase/reductase family. This group has the NAD-binding motif and active site tetrad of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.8271e-159

>NZ_CP050993.1|WP_076783158.1|1627430_1627727_-|GIY-YIG-nuclease-family-protein
MKRYYVYILLCTDNSYYTGVTNDLETRFLYHQMGYDPNAYTYNRRPVEIVYYTEFDDINQAIAFEKQLKGWSRKKKEAVINDEWEKLPNLSKRKFPNQ
>NZ_CP050993.1|WP_168638422.1|1625919_1627278_+|orotate-phosphoribosyltransferase
MESKKEFFLECYKLGIIKFGRFTLKSGIESPFYVDLRPLASDPKILKKLANYLLDMLPLDNFDIICGVPYAALPMATAMSLESYLPLIIKRKEAKAYGTKKLIEGIYEKGQNCLLVEDVITSGKSLVETIDEVENEGINVSDIVVVLDREQGGKEKLEEKGYKVHSLFNISEVVEILREVNYIDEEEVARIRDFVNGNQVVFQEKKRLSYEQKLEITEHSFAKKILEIAIEKRSNLIASADFITTQELLNFADIVGPHIVALKTHIDILNNFDADETILPLKDLAAKHNFLLMEDRKFADIGNTQELQFSYGTFKISNWADLITSHVIGGSKSLDCFVNAGIVAILGMSSEGTLTDSHYREEALKIIENHPNIVGCVAQNKVPDNILLFTPGVNLGTSGDGKGQQYNSPEHVIKNYNTDFIIVGRGIYKADDPELEALRYKTEGWQAYQDAL
>NZ_CP050993.1|WP_076783156.1|1624887_1625439_+|DNA-3-methyladenine-glycosylase
MSYCQAIETMQPEERKALHKNYHDNHYGFPIHNDDELFGRLIMEINQAGLSWETILKKEASFRKAYSNFSIEKIAAYTEKDRERLLSDAGIIRNKLKVNAAIENAKTILELKKEFVSFEKWLEHHHPKTKEEWVKLFKKTFRFTGGEIVGEFLMSIGFLKGAHSENCTINEKIFAANPKWKEK
>NZ_CP050993.1|WP_168638421.1|1623095_1624637_-|serine-hydrolase
MNKSLSFLFLLFSFCLIDAQIEDKKLDELIQNSLKTFDVPGMSVGIVKDGKLIYAKGFGFRSLNNNQPMDASTLVGIASNSKGFTCTALAILADEGKLNWDDKVTKYIPEFQMADPYVSQNITIKDLITHRAGLGLGQGDLMFFPEGGNLNVNDIVHNVRFLKPENPFRTTLDYNNIMFIVAGEVIHRVSGLQWADFIEQRIMKPVGMTASFGSYKRAIAANSQNIIDAHAPVDGKAIVVPHDWNETANAAGGILSNINDMTTWANFLLNGFVTKDGKRLVSEKNAHELWSLQIPDKVALTSPYDTHFYGYGLGWFLSDVKGHLQVQHSGGLIGTVTHFTLIPDMKLGIVVLTNQQSGAAFSTITNSVKDAYLGIENRDWLKIYGDRNKKNEDTFAKQKKEVYDKASKFRSELKDDQFIGWYKDDWFGIVEVSKLGKGYRIISKSSPKLKGDLIPYSANSFVAKWDDRSYDADAFFILNFDENGKAISARMKPISDATDFSFDFEDLDLKKIN
>NZ_CP050993.1|WP_168638420.1|1621682_1622726_-|bifunctional-transcriptional-activator/DNA-repair-protein-Ada
MNLSFDQMYQASFDKNPDFEGVFWMGVKTTGIFCRPTCTARKPKPENVEFFDNTKSAILKGYRPCKVCKPLENPDETPAAIQKLLDELSENPGLKFKDYDLVKRGLEPATVRRWFLKHHGMTFHAFQRMFKINSAFKKLQQGDNVLDVALDNGYESLSGFTDSFKNIFGVSPKNSKSEKIVDLKRIETPLGTMIACATENGICMLEFSDRKALPTELKDIAKHFNANIVQGDNPHFKILEKELQEYFEGKRLDFTVPLAPVGTDFQKKVWEILRTIPYGTTRSYQQQADILGNPKAVRAVANANGLNKISIIIPCHRVIGTNGTLTGYGGGIWRKQKLLELEKAILF
>NZ_CP050993.1|WP_168638419.1|1621024_1621558_-|GNAT-family-N-acetyltransferase
MNFSIQPILKNDDVKLIPLQENDFEQLFSVASDPLVWEQHPNKDRYKRDVFERFFEGAIESGGAFKIIEKNTGEIAGSTRFYNYNAADNSIFIGYTFYARKFWGSKMNPQVKKLMLDYIFQFVDKVNFHVGKDNLRSQKAMEKLGAKKVDEVTVAYYGEPDRLNVVFEILKTDYNIN
>NZ_CP050993.1|WP_168638418.1|1620098_1620482_+|DUF3037-domain-containing-protein
MQEPKLYEYAVIRLVPKPEREEFFNVGLIMFSKKEKFIRVKIHLCEDKFRLMHSKTEFGEVLKHLESFEKIALGERSSGSIAQLDIPERFRWLTAVKSSIIQTSRPHPGSSQDLDKTFDRLFEELVM
>NZ_CP050993.1|WP_168638417.1|1619332_1620121_+|aminotransferase-class-I-and-II
MDLSLRTVTVTRYILPLREGGSLPALAEADDDFKYVLKFRGAGHGVKALISELIGGKIAQVLGFRIPELVFANLSEDFGRSEGDEEIQDLLKASCGLNLALHYLSGAITFDPAAVKIDPKLSSEIVWLDAYLTNIDRTFRNTNMLMWHKELWLIDNGASLYFHHSWDNWEKNAVSPFTMIKDHVLLPQASELDAANEKFKAILTDDILREIVELIPEDWLQWHDTELSPAEIKAVYFQFLTRRRTHSDNFLNEAKNARAKVI
>NZ_CP050993.1|WP_168638416.1|1616629_1618957_-|T9SS-type-A-sorting-domain-containing-protein
MTVVLILLFTKVFFAQAFTENFDDITTLTGSGWYQHNNSTPAGINPVWFQGNPPSNGGPFTAYNGAANAYIACNFNSTSGGTGTISNWLLTPNRTFRNGDVITFYTRKYDVGQDYPDRMEVRLSTNGASTNVGSGATATGDFTTLLLSINPSLTVGGYPRQWTLYTITISGLPAPTSGRIAFRYFVTAAGPTGTNSDYIGLDNVVYTPYVCSVIALTPASSVLTDGTVGTPYSVTFGQSGGLGSATYTITSGSLPAGLALSSNGTLSGTPTTVGNYTFTVSATDSSGCSGSRTYSVKVSNMLQLVGSQVNISCNGSSTGSATVVATGGTAPYSYSWDTTPVQTASTATNLAAGTYQVTVTDAANVSKTLSFTITEANPINVSVSGNTTCANTAATVSAIGADEFLWYNQQADVSPYFTGQIFTTPVLQASTTYYTQGVSLSPQKVLQTTLAGGNNHRGNMFNVTAQKDLVINSFDVSPMGNTTVEVYYKEGTYVGYEFAPAAWKKLGSADVVYTGSPVNITVGKLTIPAGKTYALYVTSNQAGVALNYSNGSVGEAFSDDNMTITTGAGIEYPFSNNTSQIYTPRTWNGRINYKLIDCSGSRQAVQVTVNSTPAPTGIATQTFNQGDQLSVLNVTGVGIKWYASASDAENHINALPATTTIVHDEIYYATQTVDGCESVSSLAVHALDQTLAAGDVDKTTILTIYPNPVHDILKISSGTKINKVVITDYSGRNVLERITKGNIRENIDVRQLSQGNYIIQIFTDQEVKALKFIKN
>NZ_CP050993.1|WP_159435858.1|1615545_1615851_-|helix-turn-helix-domain-containing-protein
MAVNGFFNIKHKMTMGNHNGKRPTYRKPNFEKQDQSPGLVKKYYDNADMMQLFNVSGRTLQRWRDKGIVPYKRLGGKIYYLSQKVDELMEGNDGQDESYLG
>NZ_CP050993.1|WP_168638423.1|1627993_1630801_+|M1-family-metallopeptidase
MKRLLLCLILLFSNFWAKAQQDSILLKVKLNDDQRTIAVQQTLVYHNPHKKPIRQIKLLNWVTAYQNRQTALLKRKVEDRKKELYFAKENQLGKLESLEYSFGNVSAEILGTNHENLLIPLSEPLEYGQEIKINLRYQIRLPDARFTAYGSDAKHILLKYFFLVPETFENDNQDPSFYRDIEETANAGSYWKVDFDLAQNWKCYSNLNQTSDSEFEGLSVNDPEFLLSREIYPHFSAEIDGQKIEVQLGFQISEFQRQTLNFILPTQLKFIKSRTGNLPNKLFITQKFFNKEEFIGIDDIKWWKFKFQLFTDYEKTDLDYFSILSKKVMDDYFITDKSNDHWLKNGIKSYLEIQYLNNFYPNHKLLGNLPDNAKILGMKPLKLFHASDLKLTERYGLAYHYIYTQNLDQKITTPYGALSNFNTTAISQFEMGSLLNYISEYQGSQSFDFFLKEYLMANYEKKTTGTAFLNHLENFTQGKSAFLTPMINEKHRINFNLRHIREKESSYQVRITHKNASEIPLKIETINKSGERKTYWRDKIADTVSVAKDDVDKVVINDDYIFPETNFRDNYLYTKGLFANTKKLKLKLVKDIQNPEFNEVFLTPRLTFNAYDKVLLGLNFKNQGIFDQKFDYSVTPYYSTGTGKLTGSGALGYSILPPDSFFRSWNFAVSGSYFHYDKDLAYKKFGAATSFIFNKNPRSAIGRSLYFSYNYFERELTPQMVFNQEYDKYNLWNLGYSYSDNRLIHEKYIGTNIQWMEDFRKISAEAFYRWEYAKDKKISFRWFAGYFLKNDTKNSLFNYGISRVSNYSFSYGLLGQSATSGILSQQFILAEGGFKSFFNTSVNQFITSVNIDSHVWKWFNLYADAGVYKNKNRSAEFIWDSGVKVKVIPDFLEIYFPVASSLGFEPSFKNYGYRVRYTLVLNLGALVNNLRRGIF
>NZ_CP050993.1|WP_168638424.1|1630853_1631636_-|T9SS-type-A-sorting-domain-containing-protein
MKKIFTILSIAAVSLVSAQNLLPNPGFETWTDTTTKPDGWNATAGGTLETVNKHSGNNSIKLIPVSATTNANIAAVDVAADANALYTVGYWVLDNATNSRARHWIQFRSESANIAPASGDPFQPSTYTSDGASWVFVTAASTTPAGTTKLRFDYRVYAQNSIATDPIYLDDVTLVKGTLAVTDVKDYDKAVQFNTVVNDQIVFKLPARATVNVYSAEGKLISSNRVDNGGSVNTQNLVKGAYIVTVDNGSAKISRKVIKN
>NZ_CP050993.1|WP_168638425.1|1631720_1632425_-|T9SS-type-A-sorting-domain-containing-protein
MKKFYSLLAVVAMTAAVNAQSETITISGTNNTALANGVQGDVTYSWDKGSNSNPPKWFNSGSSARMYAKNTLTLTVPANNKITKVTLKGSAGGDYLDSVYSIDGGAALEAPKTGTVDYEILPSADGKTLVFTAGPTVSSGHSRIVSITVVYTSTLAVVDATKTKANLVKNTIVSNELIFGAAAKVSVYNAAGQVVKTAEVAENSRLDVSSLTKGTYIVAGVVNGQTVSQKIIKK
>NZ_CP050993.1|WP_168639687.1|1632613_1635820_+|hypothetical-protein
MFFALTTVNAQIFSWKNPNTPQDSLKKDSILISKINHDFFTKDTLDFIKKQNRIVYDEEVLVKNDKKRILGELSSKGSIIRGITFGNNQGSSVQSSMDMQISGKLSPDVSILASISDHNLPIQADGYTQTLQEFDKIYIQLNIKNHSIIRAGHLDLNDETTYFGRYQRRSMGLQFLTNWEKNGNKTSVDVSGGVARSEFFRMRFQGIEGNQGPYRLTGKNGELFITIISGSEQVYIDGILMKRGENQDYTINYNTGEITFTSFRPIYKQNFINVSYNYTNRNYTRFLITGSIKHQREKLKAGFSWFMENDNKNAPLSLNLSDDDRQTLVSAGNNPDAMFSPSGVETEYDVNKILYKRIFSGDTYHYEFSTDQSQKLYQVSFTYFGTGKGDYQLQQTTNNGRVFQYVGSGLGDYMAVRKLPAPEKSQVYSANVEYALDNGVIGTDVSMSNYDLNTFSSKDNRQNIGYAARVYANKTFRKNTWTGTPMVEYQVIQKNFHILDRINNVDFWRDFNLTNEFSQITQNRFIFSFLNDFNKSSKINYKLNYLEETDTYKGVKNDIDAVWKIGKFNNLAAVSYLDTKSTDLNTTFIRGAVSTELAGKKGSWMLGGSMEHNEKKYNATQLLDVTSFSWKEVFIQKKIADSARTKLLTKIYLRSNDSVQNNMLQKMNNILGLMAESQIIKTEKTQLSTLVHYRKFFYETPTIANNQNQDFVVGNMLYNQQLFKNGMRLQLFYELGNGQEAQREFQYIKVTDGQGIYKWTDYNNDGVQQLDEFEVAEYADLAQYIRVYTNSVNYLASNKNKLQVALFVNPSVIISSENAFLKRWNFNLSLLSQNSYLKGSQVLVWNPFARQSDQLLRTQNILASALFTSNDKSGWNGSYRYTDNDNLVNANFSNEAHAQKSHFMNVGYSFTKAFRADWENTVQNVSNSSQVYESRNYLLQNWETKPKATYKLTETLQTELFGALRQKKRTDGEELLKTYEISGTLQWERTKTSVRAQFSFINNQFDGNNYSIVGNQMLEGLKPGKNQVWTLYIQQAINSFIQLNVNYEGRNSGDRTIHIGSMQVRASF
>NZ_CP050993.1|WP_168638426.1|1635868_1636696_-|sulfurtransferase
MKIIPIIRPDELIRKFQTKNFKLYDVRTGPDAKGKYLEKHLKNATFVDLNSDLASIDDPKNGGRHPLPGFQHFIKTLGELGIDRDTHLVIYDDKNGANAAARFWWMLRAVGHKNVQVLDGGLQYAESQGYPLSSGNESYPETQYVSDYQNWQLPQVWIDEVKLATQNPDFVIVDVRESQRYQGITEPIDLVAGHISNAENIPFSENLDNSGLFKSPELLKTIYSDLFENYDRDKIIFHCGSGVTACHSLLALDYAGFEIPNLYVGSWSEWSRNAL
>NZ_CP050993.1|WP_168638427.1|1636888_1637857_+|NAD-dependent-epimerase/dehydratase-family-protein
METHTEKILITGALGQIGTELTAKLAEIYGKENVIASGLDKWKEGITEAGYYERLDVTNFQAVTEVIKEHNITTVYHLASLLSGTSEKQPLFAWKLNLEPLIHLCELAKEGLIKKIFWPSSIAVFGKGIPKENVGQEVVLNPTTVYGISKMAGEKWCEYYFEKYGVDIRSIRYPGLISWKAPAGGGTTDYAVEIFYEAVENGKYTSFISENTAMPMLYMDDAIDATIKLMTAPKEEVKIRYSYNLGGMSFTPAELASEIKKTIPDFEIKYEPDFRQAIADSWPASIDDSAAKQDWGLNYQFDISSMSIDMINNLKHKLKKEE
>NZ_CP050993.1|WP_168638428.1|1637937_1638690_+|polysaccharide-deacetylase
MILLTFNIAMPTYQYSEKQNIDQDQLIKTIEKKLGIILQKLELNGFLATFFIEISLVKLLEKQLKNIVYAGHEVAFFNADSDTETIEKTKIVAEQFLQKPIRGLRQKYHQIDYPEIKKMNFSYVSNIEESSINFLWRKLSSKTEIHYKNDLTIIPESQSPYSQLPFNDFVFQVTPMRYYESMITESLKSSEYVMIYTNIWQYMTAEELPYKLPFYKRLNIGTNTEKRLEKLLQYIDESEIAVSRIKDYLF
>NZ_CP050993.1|WP_168638429.1|1638742_1639948_-|metallophosphoesterase
MQKTILTLLVLFLFLELYVYQAFKTAFNTFNSKLIYWILTILVYMFLFYSVITFNKASHNYLRLQIVFSVILIFVLPKILVAVFLLLEDIVRLLGFGYQYITKEETHYPSRRRFISLVGLGSGAVLAGMFLDGIIFGKYRHRARIVRLKLKNLPESFKGYKIVQISDVHSGSFQNPKHLQHAIDLINKQDADLILFTGDMVNNYADEFVPFIDLFSQIKSRDGKLAVLGNHDYGEYGVWKSVDDRKNNIPRLIENEKKAGFEMLRNESRVIERNGEKLYIIGVENWGIPPFPQFGDLDKAAAGIPVDAVKILMSHDPSHFDAIVKHHPSNVQLTLSGHTHGMQFGIDLKNFRWSPVEYKYPKWADLYESKGKYLYVNRGFGVIGYPGRVGVLPEITVFELS
>NZ_CP050993.1|WP_168638430.1|1640036_1641116_-|ketoacyl-ACP-synthase-III
MPNTLIIGSGSYIPENIIEGSYFKDAVFYDDNNELIEKPTEEIVQKFVDITEIERRRYINAEDCNSDLALRASVEAIEDAGIDKEEIDYIIYATNFGEVDVNGIPNFMPSMSARLKGKLGIKRRDCINYDMIFGCPGWVEALILADTLIKAGKAKTVLVVGGETLSRITDPFDRNKMIFADGAGAVVVKATEDTTVGVLADNTLCDNGEELCYLENGPSLNPDFDEKRLYIRMRGRKIYEYALKNVPDAIKATIDKAGLDISDISKILIHQANAKMDYAMIGRLFRLYGQREYDHSISPMTIQELGNSSVATVPTLFDLIRKGKLEGQQFIPGSYILFTSVGAGMNINCVVYKFPEGKI
>NZ_CP050993.1|WP_168638431.1|1641274_1641871_+|YigZ-family-protein
MFEFQTISKAIEDILLKEKGSKFIGFAYPVNSESEIKEKLSHLRALHPKATHHCYAYRLGLNGENYRANDDGEPSGSAGLPIYNQLLAHQVTNILLVVIRYYGGTKLGVGGLVKTYKESAKYTLEQAKIITKELESGLEVRFKFSQQNLIFTLLNKYDAKIIDFDAKEICVIKAHIKTSKKESISDELSEMLLEFNFS

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Crispr_ID: NZ_CP050993_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050993_5

2143634-2143721

Orphan

Consensus_repeat	Method
TTTTAGGGTGAGCGCAATTCCGAATTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050993_5

>merge|NZ_CP050993|5|2143634-2143721|CRISPRCasFinder
TTTCGGAGTGAGCGCAATTCCGAAATATCACTCAAAAATTTTGGCACTTTAACACTTTCTTAACCTCAGTGACCGCAATTCCGAATTC

>NZ_CP050993|5|5|2143634-2143721|CRISPRCasFinder
TTTCGGAGTGAGCGCAATTCCGAAATA	TCACTCAAAAATTTTGGCACTTTAACACTTTCTT
AACCTCAGTGACCGCAATTCCGAATTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050993.1\|WP_066439468.1\|2147635_2148481_-\|RteC-domain-containing-protein	unknown	unknown	gnl\|CDD\|378161
NZ_CP050993.1\|WP_034975977.1\|2138022_2138235_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_034976002.1\|2145955_2146207_-\|DUF3853-family-protein	unknown	unknown	gnl\|CDD\|372411
NZ_CP050993.1\|WP_034975966.1\|2136252_2136471_-\|PRTRC-system-protein-C	unknown	unknown	gnl\|CDD\|316934
NZ_CP050993.1\|WP_168638736.1\|2150508_2151594_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236875
NZ_CP050993.1\|WP_066439471.1\|2146213_2146756_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168638735.1\|2148532_2149174_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP050993.1\|WP_168638734.1\|2145201_2145954_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|260010
NZ_CP050993.1\|WP_066439493.1\|2134173_2134920_-\|PRTRC-system-protein-B	unknown	unknown	gnl\|CDD\|373078
NZ_CP050993.1\|WP_034975972.1\|2137520_2138009_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375832
NZ_CP050993.1\|WP_168638731.1\|2137082_2137520_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168639704.1\|2134963_2135887_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_066439470.1\|2146772_2147036_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378935
NZ_CP050993.1\|WP_034975986.1\|2140351_2142454_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224125
NZ_CP050993.1\|WP_034975989.1\|2142455_2143313_-\|DNA-primase	unknown	unknown	gnl\|CDD\|273595
NZ_CP050993.1\|WP_034975981.1\|2138249_2138645_-\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|239942
NZ_CP050993.1\|WP_168638732.1\|2143742_2144873_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168638730.1\|2136488_2137031_-\|PRTRC-system-protein-E	unknown	unknown	gnl\|CDD\|274758
NZ_CP050993.1\|WP_124986562.1\|2149198_2150512_-\|IS1380-family-transposase	unknown	unknown	gnl\|CDD\|379340
NZ_CP050993.1\|WP_168638733.1\|2144946_2145153_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP050993.1\|WP_168638736.1\|2150508_2151594_-\|hypothetical-protein	gnl\|CDD\|236875	PRK11189, PRK11189, lipoprotein NlpI; Provisional.	0.00329003
NZ_CP050993.1\|WP_034976002.1\|2145955_2146207_-\|DUF3853-family-protein	gnl\|CDD\|372411	pfam12964, DUF3853, Protein of unknown function (DUF3853). A family of uncharacterized proteins found by clustering human gut metagenomic sequences.	4.24097e-19
NZ_CP050993.1\|WP_034975966.1\|2136252_2136471_-\|PRTRC-system-protein-C	gnl\|CDD\|316934	pfam14454, Prok_Ub, Prokaryotic Ubiquitin. A Ubiquitin-superfamily protein that is present across several bacterial lineages, and found in gene neighborhoods with components of the ubiquitin modification system such as the E1, E2 and JAB proteins, and a novel alpha-helical protein, which is predicted to be enzymatic.	7.02511e-24
NZ_CP050993.1\|WP_168638735.1\|2148532_2149174_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	2.74908e-06
NZ_CP050993.1\|WP_168638734.1\|2145201_2145954_-\|hypothetical-protein	gnl\|CDD\|260010	cd09278, RNase_HI_prokaryote_like, RNase HI family found mainly in prokaryotes. Ribonuclease H (RNase H) is classified into two evolutionarily unrelated families, type 1 (prokaryotic RNase HI, eukaryotic RNase H1 and viral RNase H) and type 2 (prokaryotic RNase HII and HIII, and eukaryotic RNase H2). RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. RNase H is involved in DNA replication, repair and transcription. RNase H is widely present in various organisms, including bacteria, archaea and eukaryotes and most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site (DEDD), residues and have the same catalytic mechanism and functions in cells. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. Prokaryotic RNase H varies greatly in domain structures and substrate specificities. Prokaryotes and some single-cell eukaryotes do not require RNase H for viability.	0.00229097
NZ_CP050993.1\|WP_066439493.1\|2134173_2134920_-\|PRTRC-system-protein-B	gnl\|CDD\|373078	pfam14460, Prok-E2_D, Prokaryotic E2 family D. A member of the E2/UBC superfamily of proteins found in several bacteria. Members of this family lack the conserved histidine of the classical E2-fold. However, they have an absolutely conserved histidine carboxyl-terminal to the conserved cysteine. Members of this family are usually present in a conserved gene neighborhood with genes encoding members of the Ub modification pathway such as the E1, Ub and JAB proteins. These neighborhoods also contain a gene encoding a rapidly diverging alpha-helical protein.	4.20537e-35
NZ_CP050993.1\|WP_034975972.1\|2137520_2138009_-\|hypothetical-protein	gnl\|CDD\|375832	pfam18406, DUF1281_C, Ferredoxin-like domain in Api92-like protein. This domain has a ferredoxin like fold. It is often found to the C terminus of pfam06924.	2.1681e-08
NZ_CP050993.1\|WP_066439468.1\|2147635_2148481_-\|RteC-domain-containing-protein	gnl\|CDD\|378161	pfam09357, RteC, RteC protein. Human colonic Bacteroides species harbor a family of large conjugative transposons, called tetracycline resistance (Tcr) elements. Activities of these elements are enhanced by pregrowth of bacteria in medium containing tetracycline, indicating that at least some Tcr element genes are regulated by tetracycline. An insertional disruption in the rteC gene abolished self-transfer of the Tcr element to Bacteroides recipients, indicating that the gene was essential for self-transfer.	3.98095e-79
NZ_CP050993.1\|WP_066439470.1\|2146772_2147036_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	2.10237e-06
NZ_CP050993.1\|WP_034975986.1\|2140351_2142454_+\|hypothetical-protein	gnl\|CDD\|224125	COG1204, COG1204, Superfamily II helicase [General function prediction only].	1.32129e-24
NZ_CP050993.1\|WP_034975989.1\|2142455_2143313_-\|DNA-primase	gnl\|CDD\|273595	TIGR01391, DNA_primase, DNA primase, catalytic core. Members of this family are DNA primase, a ubiquitous bacteria protein. Most members of this family contain nearly two hundred additional residues C-terminal to the region represented here, but conservation between species is poor and the C-terminal region was not included in the seed alignment. This protein contains a CHC2 zinc finger (pfam01807) and a Toprim domain (pfam01751). [DNA metabolism, DNA replication, recombination, and repair].	2.78818e-08
NZ_CP050993.1\|WP_034975981.1\|2138249_2138645_-\|single-stranded-DNA-binding-protein	gnl\|CDD\|239942	cd04496, SSB_OBF, SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date oligomerize to bring together four OB folds in their active state. The majority (e.g. Escherichia coli SSB) have a single OB fold per monomer, which oligomerize to form a homotetramer. However, Deinococcus and Thermus SSB proteins have two OB folds per monomer, which oligomerize to form a homodimer. Mycobacterium tuberculosis SSB varies in quaternary structure from E. coli SSB. It forms a dimer of dimers having a unique dimer interface, which lends the protein greater stability. Included in this group are OB folds similar to Escherichia coli PriB. E.coli PriB is homodimeric with each monomer having a single OB fold. It does not appear to form higher order oligomers. PriB is an essential protein for the replication restart at forks that have stalled at sites of DNA damage. It also plays a role in the assembly of primosome during replication initiation at the bacteriophage phiX174 origin. PriB physically interacts with SSB and binds ssDNA with high affinity.	3.82902e-21
NZ_CP050993.1\|WP_168638730.1\|2136488_2137031_-\|PRTRC-system-protein-E	gnl\|CDD\|274758	TIGR03741, PRTRC_E, PRTRC system protein E. A novel genetic system characterized by six or seven major proteins, included a ParB homolog and a ThiF homolog, is designated PRTRC, or ParB-Related,ThiF-Related Cassette. It is often found on plasmids. This protein family averages about 150 amino acids in length, but the last third contains low-complexity sequence that complicates sequence comparisons. This model does not include the low-complexity region.	0.000675484
NZ_CP050993.1\|WP_124986562.1\|2149198_2150512_-\|IS1380-family-transposase	gnl\|CDD\|379340	pfam13701, DDE_Tnp_1_4, Transposase DDE domain group 1. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	6.87863e-37

>NZ_CP050993.1|WP_034975989.1|2142455_2143313_-|DNA-primase
MNCEEVKEKVNIRTVLESFSLFPVKENRKTALYFALDREEKIPSFSVDFVKNKAFDFGTGKSYDVISIVQQMNRCSVSDALKYLEKFDFSVQNHIRIEDTVQVKNYQIIKVNEIKHPALIQYLKSRKVCEQKDLVKQIEYMLNGKKYFGIGFFNNSGGVEIRSKYSKICLGKKDVTLIKNDLNTSNEIVVFEGFFDYLTFKNLESAESSISDCLILNSTAMLFRVEESLKEYDRISLFLDNDPNGNATRETIQKKYKNVEDCSLVYKDFIDLNEWFCMNTTENKF
>NZ_CP050993.1|WP_034975986.1|2140351_2142454_+|hypothetical-protein
MQEQVFDRCHIINGLLIDNQENEARQELIKLLDFHNTNQLAYNPLVNHLIRETGLFPYLELETSNWEERFIYNAFKVDVGEENPLTLHREQSFLLKKLLEGKNIAVSAPTSFGKSFVIDAYIKIKKPNNVLIIVPTLALTDETRRRLYKKFAHEYKIITTSDVELSDKNIFIFPQERAMNYINIVESFDIMIVDEFYKASSKFDKERSPSLIRAMIKLGAKSNQKYYLAPNITSLENNPFTDDMEFIRLDFNTVFLEKHELYNQIKNNDEKSEVLLEILSKNKGKSLIYAGTYSNIDSLTILFLATYEPVKNELLEMFANWLSKNYDFNWSLTKLVSREIGVHNGRLHRSLSQIQVKLFEEGEGIRNLISTSSIIEGVNTSAENVIIWRNRKGSAKLDDFTYKNIIGRGGRMFKHFIGKIYILEQPPEEGLTQLSIPFPDEILGDLEESKYDGLLTKEQVAKLKFYNDEMAELVGAKVYEELKSESIFQSSNSDLIKAIAIDLTKNPDEWNGLYYLNEFKPENWDRLLYKVIKLQPGNWDCSYKTFVEFIKIMAYNWTKSIPELLKELEDYDVGIDTFFLLERNVTYKFSALLNDLNTLQKRILKNKQYDISKFIKWCSNAFLPKVVFQLEEYGLPRMISKKIHESKVIDFYDSDLTIHKVVEKFNEIGKEMTIEKTNNLDEFDKYILNYFFDGIKIMNA
>NZ_CP050993.1|WP_034975981.1|2138249_2138645_-|single-stranded-DNA-binding-protein
MNIVGRITRNAEINHLKDDKQVVNFSVAINDSYKTKQGERREQTTYYNCSYWLSPNVAKILTKGTLVELTGRASSSGWIGKDGEIKSGLNFHTSNIKVHGGGKKSDTDEQPASQPQKSNVFAEDTDDDLPF
>NZ_CP050993.1|WP_034975977.1|2138022_2138235_-|hypothetical-protein
MEAQYNFQMKPKSDKNDWEKVEVFSQFYCERTTAIRYAKSLSRKFKSEIRLTEGKDPLKTSGTYIYENNN
>NZ_CP050993.1|WP_034975972.1|2137520_2138009_-|hypothetical-protein
MANWCNNKVTFNGDKDSLNKVLALFKEMIEKESKGNIGQLPDFIESKNGYFFEIYCDETDECSFHYETRWSPNIESLWMVATHYNVGFVLDYEESGCMVYGKTIYENEILQDYFLNQCDFQDCIYNVDTDCYEFEGTSYDYQDEIMRILLDRKINNNKQKIA
>NZ_CP050993.1|WP_168638731.1|2137082_2137520_-|hypothetical-protein
MKRSLQQTEYLLIKTMTNSGWDNGDFAIIHITGEWKETQKKRLEAVKPLENDYDLKWLNYADTNVEFFRFSEETHPEIEEWLSEKDSVFIELETDELKKLFQSENNLNCYQMQVFKNGNAIYNAFGKHTGEEFWTKEFSLWELTK
>NZ_CP050993.1|WP_168638730.1|2136488_2137031_-|PRTRC-system-protein-E
MQTNFFRQIAKLNLKGDLQITLRQSTENSFVLSVLLNNEQCADEARKTIPPLNLRGTAEDLDNGFFEHISTPLQTASGLMVDMESFMKQVEEAKKKSAMEKEKSDKEKKEKEAKDKKYGEALQKAEELEKEGKYKEAWSALPKGSEFPEYAEKIRKKQDEYEGHFAPSLFSENQPQSTEI
>NZ_CP050993.1|WP_034975966.1|2136252_2136471_-|PRTRC-system-protein-C
MLLATLLDRVFILKDNGQEIRLTDPEPKWSVEAVMNFYANTYPILTTSKISAPKIKDDAVEYQFESVVGTKG
>NZ_CP050993.1|WP_168639704.1|2134963_2135887_-|hypothetical-protein
MERDFYKSLSQLAKHYDITTMPTQHFNYPYNISLALRDIEAQLKTKSENWQSIRLIKKASKTYFAIEERCNTGATLFYVPVVPLYQFLHNKVHRKAACLLLSVCAYLYRNADVPYYRLEDTYLYYNYEMLNDWLEQDEEIEDSHNSKKELQRAEIIGDMMGQKISNHKNVLFFEQRLKRFRPKDRFDKECLQLAEKAFKLYCDYPNESIKRNAHYNNAVKSEDMDEDDYYNEETVVAMDKYISFFAESDGLIYDNLMSCVNNEFNEYAETQEPIIFKTFNGSDITDKNLDFENQLFKVLNEFCRLLN
>NZ_CP050993.1|WP_066439493.1|2134173_2134920_-|PRTRC-system-protein-B
MRNTANTIENEEIDITNNFGTLYHPKSALVFYETEDYNPDGYVEHFDIDRNGNPINAHPLTVREAQRLSKMLNIQNKKDKDFLRPSGVISESILFIDTSENGKVVWYTKAQERHLLFTDKLSIPNGLAYLPPLVWCANKQGMKIFALETNQRPSEETPLFHAPFFNVYESGSVCMGTVDVKIKSSTSLEEFTNKWEDYFFNSYFSHLVNNHNPTKGNCVNLWKNLIQSKEVFPTDILINSNLTLKNLL
>NZ_CP050993.1|WP_168638732.1|2143742_2144873_-|hypothetical-protein
MAVPEKDLRLIRKEFENNDEINTERIRLGNGFVDDFILEGYEAADIPINALRVIFNIVSTISNEQFRPEDRPKQLSLFDEEFETENNIFASLKIRNSKISPSGSTKQVVDAYEFLTKFKMSWYKSTNSKGKEIKTFGGLISIPSYDQRGYTTFLISSYWLKKLMVIPQYNYVLYNLVYNIRNNKHIIFAIWLAKLPENGAVLKLSTLNKKFGLKYKTSKDFCFKFLKPARISLNTFNTLSFNYNYRGDSIFIIPYLTKTILNNNLSLNTREQLESNEAYLDHREKTAQRLSYIKKRYGLHENEMLQFSHQYRNVPQTRVLIEKAFKEFIRTARLNESKSTEFQGKLFLNEIQEHLIQIYRCTKMGELLPNGYPIII
>NZ_CP050993.1|WP_168638733.1|2144946_2145153_-|hypothetical-protein
MTLSDLKPGQKVTINGMLAEYKGIQKVKIPNFGKVEKRVFQGQGINIYKYYNLNEGAKTLVSEKIELI
>NZ_CP050993.1|WP_168638734.1|2145201_2145954_-|hypothetical-protein
MHHLELMQRFWDFNQKKSIGTTGISMYLYLLKIGSDNDSCDFQISDVVISIELGVTRKTVKSTKEKLRNLGLIQYQTTSGLACKYRLIGDYPSQISEPEMVRKKEIGKEESIQKTVESGVSLLTDRPVQNFSENTIDQEIESYLSQSIQSLQPQPTNQKGNDENIPSLEEFMTYAETLKIYEPELDSEIQSKYENWKKNGWKNSSDRPITNWRSSLKSTLPFMKSQTESHQLSLQSIPDIKRPKSQNGNL
>NZ_CP050993.1|WP_034976002.1|2145955_2146207_-|DUF3853-family-protein
MKNIDPKTPIWRLTVEEFLEVSKKINSEKKYEYGLKGLAKMLGCSISKASEIKSSGLLDDAIIQKGNIIIIDKEKALALFAQK
>NZ_CP050993.1|WP_066439471.1|2146213_2146756_-|hypothetical-protein
MKNNRNIIVFFERVIEDDRLYPSHISMYVSLFQFWSLNRFQNPFRISREDVMNLSKIRSIATYHKCIRELYRAGFIRYSPSYNSYKGSLIEIIDFDSEKVGEKKISHNQNFLPQDDIRFLVPVFNEVELYFTERDFPSAEADRFFSFYRSKNWKLSNEKPMKCWRAAARNWISALKNAIN
>NZ_CP050993.1|WP_066439470.1|2146772_2147036_-|helix-turn-helix-domain-containing-protein
MAISIITKEDLQQFKIELLEGIEILLKGKTTEQKLWLRSSEVKKLLNISSGTLQNLRINGTLSYSKIGGSLYYNYKDIQKLLSDVKH
>NZ_CP050993.1|WP_066439468.1|2147635_2148481_-|RteC-domain-containing-protein
MNGQNFKKKVDQLWKDLTTAVDQINRSENDIVIRAEEILMETDASIRQLKDLLRQYQFPDWSNEIYFFKNTKPQFVAVYIYYSKVLAVEASKPYADSQALRSYYENERSNLLYFYNEQREFISYYRRKSTYLDKKYFVRFKFDFKLKLSPELYSYDEEFSTSHDHIVSQIMANDLLEQYLTNKIDSKDSKENSIAHIKNLEWTAPKVALIELLYALHQTKCFNGGHSDLAEIFRWAENSLNIGLGNYHKTLSEIRLRKTDRTKFLSLLQQNFNQYLDDLDL
>NZ_CP050993.1|WP_168638735.1|2148532_2149174_-|helix-turn-helix-transcriptional-regulator
MLTDKIYSEYDKENLLEEKKQMIRGHQVILYSSIGAGLVILFFLIWRFRKREKELNARYQEVLEKLNTSKDTISFDVIAPASSDENILELYSSEIIEDIKTNLKIFEDEKQFLQQNLTLDIVAKMIGSNRTHLSYVLNVHFYVTFPTYLKALRIRYITNLLVEETIYLSYKIETLAKICGMANRQIFSAHFLEINSIRPRDFIRMRQEELKKT
>NZ_CP050993.1|WP_124986562.1|2149198_2150512_-|IS1380-family-transposase
MKFDLSFTNKEITPWGGMVFLKQMLDKIGFREQIEKCESLPVSLSNNSYKKEVLLESFITSIWCGANRFLHTEITRADKALGEIFDWRKTPAQDAYKRYFGKFTQHINQQVGHHFFSWFFQNLNLNYFTLDIDSSVITRYGEQEGAKKGYNPKKKGRNSHHPIIAFVNDVKMVANFWLRSGDTSSANNFVGFLEETLLNFGDKKVGLVRLDSGFFQKDIMDYLELKTLQYIIAAKFTHPIQHLIDQQDFWIKVDEGIEICDKYYQAKNWEKPRRIVIVRQKTAQRPNAAGRILSLFPEDEIHRNYRYSAYITNQEQSATDVWRTYRNRGDAENRIKELKADFGAESFNLKGFFPTEAALIFSMIAYNLMSIFRLFVLQEKTQKTLSTLRYRTFAIGAYFEKVGDTLKLKIALTKKRRKWFVGIWDYPIDLSQKISTA
>NZ_CP050993.1|WP_168638736.1|2150508_2151594_-|hypothetical-protein
MTQGKEIQQQSYKEISRLVDSYSENDERAMVFVKMYIDKAKNDHNHKKLIRGYEEAIYYSKETSRKLSYADSAIVTALKSNDQDQIARAYAGKGIIYYYNLRQYKKALEEYLIAFKYSKNSKDGYLKNKIIYHLGMIKSYLGYYKYAALHFEEAADFFEKNAKESLDRNIRYNNESGYFNSIYRLSTCYKNLKLYHKEDSLINIGLERLHNNSELVIEFGYFQKGKGAQLLRKGKADEALKHFKVSQDILSSNQDYASLTSVYFYIGKLYRSKGNRAESLNYFNKVDSLVNKFWFITPEIRSSYLYLIDDAKKNGDSERKMYFGDQLLKADSIINPNSAIEKKEYFSILISNCVAVEKNKR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP050993_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050993_4

2143441-2143547

Orphan

Consensus_repeat	Method
TTTTAGGGTGAGCGCAATTCCGAATTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050993_4

>merge|NZ_CP050993|4|2143441-2143547|CRISPRCasFinder
TTTTAGGGTGAGCGCAATTCCGAATTCTGGTGAGTGCAATTCCGAAAATAGAGTGACCGTAATTCCGAAAAGACAACTGTTTTAGGGTGAGTGCAATTCCGAATTCA

>NZ_CP050993|4|4|2143441-2143547|CRISPRCasFinder
TTTTAGGGTGAGCGCAATTCCGAATTC	TGGTGAGTGCAATTCCGAAAATAGAGTGACCGTAATTCCGAAAAGACAACTG
TTTTAGGGTGAGTGCAATTCCGAATTCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050993.1\|WP_066439468.1\|2147635_2148481_-\|RteC-domain-containing-protein	unknown	unknown	gnl\|CDD\|378161
NZ_CP050993.1\|WP_034975977.1\|2138022_2138235_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_034976002.1\|2145955_2146207_-\|DUF3853-family-protein	unknown	unknown	gnl\|CDD\|372411
NZ_CP050993.1\|WP_034975966.1\|2136252_2136471_-\|PRTRC-system-protein-C	unknown	unknown	gnl\|CDD\|316934
NZ_CP050993.1\|WP_168638736.1\|2150508_2151594_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236875
NZ_CP050993.1\|WP_066439471.1\|2146213_2146756_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168638735.1\|2148532_2149174_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP050993.1\|WP_168638734.1\|2145201_2145954_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|260010
NZ_CP050993.1\|WP_066439493.1\|2134173_2134920_-\|PRTRC-system-protein-B	unknown	unknown	gnl\|CDD\|373078
NZ_CP050993.1\|WP_034975972.1\|2137520_2138009_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375832
NZ_CP050993.1\|WP_168638731.1\|2137082_2137520_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168639704.1\|2134963_2135887_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_066439470.1\|2146772_2147036_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378935
NZ_CP050993.1\|WP_034975986.1\|2140351_2142454_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224125
NZ_CP050993.1\|WP_034975989.1\|2142455_2143313_-\|DNA-primase	unknown	unknown	gnl\|CDD\|273595
NZ_CP050993.1\|WP_034975981.1\|2138249_2138645_-\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|239942
NZ_CP050993.1\|WP_168638732.1\|2143742_2144873_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168638730.1\|2136488_2137031_-\|PRTRC-system-protein-E	unknown	unknown	gnl\|CDD\|274758
NZ_CP050993.1\|WP_124986562.1\|2149198_2150512_-\|IS1380-family-transposase	unknown	unknown	gnl\|CDD\|379340
NZ_CP050993.1\|WP_168638733.1\|2144946_2145153_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP050993.1\|WP_168638736.1\|2150508_2151594_-\|hypothetical-protein	gnl\|CDD\|236875	PRK11189, PRK11189, lipoprotein NlpI; Provisional.	0.00329003
NZ_CP050993.1\|WP_034976002.1\|2145955_2146207_-\|DUF3853-family-protein	gnl\|CDD\|372411	pfam12964, DUF3853, Protein of unknown function (DUF3853). A family of uncharacterized proteins found by clustering human gut metagenomic sequences.	4.24097e-19
NZ_CP050993.1\|WP_034975966.1\|2136252_2136471_-\|PRTRC-system-protein-C	gnl\|CDD\|316934	pfam14454, Prok_Ub, Prokaryotic Ubiquitin. A Ubiquitin-superfamily protein that is present across several bacterial lineages, and found in gene neighborhoods with components of the ubiquitin modification system such as the E1, E2 and JAB proteins, and a novel alpha-helical protein, which is predicted to be enzymatic.	7.02511e-24
NZ_CP050993.1\|WP_168638735.1\|2148532_2149174_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	2.74908e-06
NZ_CP050993.1\|WP_168638734.1\|2145201_2145954_-\|hypothetical-protein	gnl\|CDD\|260010	cd09278, RNase_HI_prokaryote_like, RNase HI family found mainly in prokaryotes. Ribonuclease H (RNase H) is classified into two evolutionarily unrelated families, type 1 (prokaryotic RNase HI, eukaryotic RNase H1 and viral RNase H) and type 2 (prokaryotic RNase HII and HIII, and eukaryotic RNase H2). RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. RNase H is involved in DNA replication, repair and transcription. RNase H is widely present in various organisms, including bacteria, archaea and eukaryotes and most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site (DEDD), residues and have the same catalytic mechanism and functions in cells. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. Prokaryotic RNase H varies greatly in domain structures and substrate specificities. Prokaryotes and some single-cell eukaryotes do not require RNase H for viability.	0.00229097
NZ_CP050993.1\|WP_066439493.1\|2134173_2134920_-\|PRTRC-system-protein-B	gnl\|CDD\|373078	pfam14460, Prok-E2_D, Prokaryotic E2 family D. A member of the E2/UBC superfamily of proteins found in several bacteria. Members of this family lack the conserved histidine of the classical E2-fold. However, they have an absolutely conserved histidine carboxyl-terminal to the conserved cysteine. Members of this family are usually present in a conserved gene neighborhood with genes encoding members of the Ub modification pathway such as the E1, Ub and JAB proteins. These neighborhoods also contain a gene encoding a rapidly diverging alpha-helical protein.	4.20537e-35
NZ_CP050993.1\|WP_034975972.1\|2137520_2138009_-\|hypothetical-protein	gnl\|CDD\|375832	pfam18406, DUF1281_C, Ferredoxin-like domain in Api92-like protein. This domain has a ferredoxin like fold. It is often found to the C terminus of pfam06924.	2.1681e-08
NZ_CP050993.1\|WP_066439468.1\|2147635_2148481_-\|RteC-domain-containing-protein	gnl\|CDD\|378161	pfam09357, RteC, RteC protein. Human colonic Bacteroides species harbor a family of large conjugative transposons, called tetracycline resistance (Tcr) elements. Activities of these elements are enhanced by pregrowth of bacteria in medium containing tetracycline, indicating that at least some Tcr element genes are regulated by tetracycline. An insertional disruption in the rteC gene abolished self-transfer of the Tcr element to Bacteroides recipients, indicating that the gene was essential for self-transfer.	3.98095e-79
NZ_CP050993.1\|WP_066439470.1\|2146772_2147036_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	2.10237e-06
NZ_CP050993.1\|WP_034975986.1\|2140351_2142454_+\|hypothetical-protein	gnl\|CDD\|224125	COG1204, COG1204, Superfamily II helicase [General function prediction only].	1.32129e-24
NZ_CP050993.1\|WP_034975989.1\|2142455_2143313_-\|DNA-primase	gnl\|CDD\|273595	TIGR01391, DNA_primase, DNA primase, catalytic core. Members of this family are DNA primase, a ubiquitous bacteria protein. Most members of this family contain nearly two hundred additional residues C-terminal to the region represented here, but conservation between species is poor and the C-terminal region was not included in the seed alignment. This protein contains a CHC2 zinc finger (pfam01807) and a Toprim domain (pfam01751). [DNA metabolism, DNA replication, recombination, and repair].	2.78818e-08
NZ_CP050993.1\|WP_034975981.1\|2138249_2138645_-\|single-stranded-DNA-binding-protein	gnl\|CDD\|239942	cd04496, SSB_OBF, SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date oligomerize to bring together four OB folds in their active state. The majority (e.g. Escherichia coli SSB) have a single OB fold per monomer, which oligomerize to form a homotetramer. However, Deinococcus and Thermus SSB proteins have two OB folds per monomer, which oligomerize to form a homodimer. Mycobacterium tuberculosis SSB varies in quaternary structure from E. coli SSB. It forms a dimer of dimers having a unique dimer interface, which lends the protein greater stability. Included in this group are OB folds similar to Escherichia coli PriB. E.coli PriB is homodimeric with each monomer having a single OB fold. It does not appear to form higher order oligomers. PriB is an essential protein for the replication restart at forks that have stalled at sites of DNA damage. It also plays a role in the assembly of primosome during replication initiation at the bacteriophage phiX174 origin. PriB physically interacts with SSB and binds ssDNA with high affinity.	3.82902e-21
NZ_CP050993.1\|WP_168638730.1\|2136488_2137031_-\|PRTRC-system-protein-E	gnl\|CDD\|274758	TIGR03741, PRTRC_E, PRTRC system protein E. A novel genetic system characterized by six or seven major proteins, included a ParB homolog and a ThiF homolog, is designated PRTRC, or ParB-Related,ThiF-Related Cassette. It is often found on plasmids. This protein family averages about 150 amino acids in length, but the last third contains low-complexity sequence that complicates sequence comparisons. This model does not include the low-complexity region.	0.000675484
NZ_CP050993.1\|WP_124986562.1\|2149198_2150512_-\|IS1380-family-transposase	gnl\|CDD\|379340	pfam13701, DDE_Tnp_1_4, Transposase DDE domain group 1. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	6.87863e-37

>NZ_CP050993.1|WP_034975989.1|2142455_2143313_-|DNA-primase
MNCEEVKEKVNIRTVLESFSLFPVKENRKTALYFALDREEKIPSFSVDFVKNKAFDFGTGKSYDVISIVQQMNRCSVSDALKYLEKFDFSVQNHIRIEDTVQVKNYQIIKVNEIKHPALIQYLKSRKVCEQKDLVKQIEYMLNGKKYFGIGFFNNSGGVEIRSKYSKICLGKKDVTLIKNDLNTSNEIVVFEGFFDYLTFKNLESAESSISDCLILNSTAMLFRVEESLKEYDRISLFLDNDPNGNATRETIQKKYKNVEDCSLVYKDFIDLNEWFCMNTTENKF
>NZ_CP050993.1|WP_034975986.1|2140351_2142454_+|hypothetical-protein
MQEQVFDRCHIINGLLIDNQENEARQELIKLLDFHNTNQLAYNPLVNHLIRETGLFPYLELETSNWEERFIYNAFKVDVGEENPLTLHREQSFLLKKLLEGKNIAVSAPTSFGKSFVIDAYIKIKKPNNVLIIVPTLALTDETRRRLYKKFAHEYKIITTSDVELSDKNIFIFPQERAMNYINIVESFDIMIVDEFYKASSKFDKERSPSLIRAMIKLGAKSNQKYYLAPNITSLENNPFTDDMEFIRLDFNTVFLEKHELYNQIKNNDEKSEVLLEILSKNKGKSLIYAGTYSNIDSLTILFLATYEPVKNELLEMFANWLSKNYDFNWSLTKLVSREIGVHNGRLHRSLSQIQVKLFEEGEGIRNLISTSSIIEGVNTSAENVIIWRNRKGSAKLDDFTYKNIIGRGGRMFKHFIGKIYILEQPPEEGLTQLSIPFPDEILGDLEESKYDGLLTKEQVAKLKFYNDEMAELVGAKVYEELKSESIFQSSNSDLIKAIAIDLTKNPDEWNGLYYLNEFKPENWDRLLYKVIKLQPGNWDCSYKTFVEFIKIMAYNWTKSIPELLKELEDYDVGIDTFFLLERNVTYKFSALLNDLNTLQKRILKNKQYDISKFIKWCSNAFLPKVVFQLEEYGLPRMISKKIHESKVIDFYDSDLTIHKVVEKFNEIGKEMTIEKTNNLDEFDKYILNYFFDGIKIMNA
>NZ_CP050993.1|WP_034975981.1|2138249_2138645_-|single-stranded-DNA-binding-protein
MNIVGRITRNAEINHLKDDKQVVNFSVAINDSYKTKQGERREQTTYYNCSYWLSPNVAKILTKGTLVELTGRASSSGWIGKDGEIKSGLNFHTSNIKVHGGGKKSDTDEQPASQPQKSNVFAEDTDDDLPF
>NZ_CP050993.1|WP_034975977.1|2138022_2138235_-|hypothetical-protein
MEAQYNFQMKPKSDKNDWEKVEVFSQFYCERTTAIRYAKSLSRKFKSEIRLTEGKDPLKTSGTYIYENNN
>NZ_CP050993.1|WP_034975972.1|2137520_2138009_-|hypothetical-protein
MANWCNNKVTFNGDKDSLNKVLALFKEMIEKESKGNIGQLPDFIESKNGYFFEIYCDETDECSFHYETRWSPNIESLWMVATHYNVGFVLDYEESGCMVYGKTIYENEILQDYFLNQCDFQDCIYNVDTDCYEFEGTSYDYQDEIMRILLDRKINNNKQKIA
>NZ_CP050993.1|WP_168638731.1|2137082_2137520_-|hypothetical-protein
MKRSLQQTEYLLIKTMTNSGWDNGDFAIIHITGEWKETQKKRLEAVKPLENDYDLKWLNYADTNVEFFRFSEETHPEIEEWLSEKDSVFIELETDELKKLFQSENNLNCYQMQVFKNGNAIYNAFGKHTGEEFWTKEFSLWELTK
>NZ_CP050993.1|WP_168638730.1|2136488_2137031_-|PRTRC-system-protein-E
MQTNFFRQIAKLNLKGDLQITLRQSTENSFVLSVLLNNEQCADEARKTIPPLNLRGTAEDLDNGFFEHISTPLQTASGLMVDMESFMKQVEEAKKKSAMEKEKSDKEKKEKEAKDKKYGEALQKAEELEKEGKYKEAWSALPKGSEFPEYAEKIRKKQDEYEGHFAPSLFSENQPQSTEI
>NZ_CP050993.1|WP_034975966.1|2136252_2136471_-|PRTRC-system-protein-C
MLLATLLDRVFILKDNGQEIRLTDPEPKWSVEAVMNFYANTYPILTTSKISAPKIKDDAVEYQFESVVGTKG
>NZ_CP050993.1|WP_168639704.1|2134963_2135887_-|hypothetical-protein
MERDFYKSLSQLAKHYDITTMPTQHFNYPYNISLALRDIEAQLKTKSENWQSIRLIKKASKTYFAIEERCNTGATLFYVPVVPLYQFLHNKVHRKAACLLLSVCAYLYRNADVPYYRLEDTYLYYNYEMLNDWLEQDEEIEDSHNSKKELQRAEIIGDMMGQKISNHKNVLFFEQRLKRFRPKDRFDKECLQLAEKAFKLYCDYPNESIKRNAHYNNAVKSEDMDEDDYYNEETVVAMDKYISFFAESDGLIYDNLMSCVNNEFNEYAETQEPIIFKTFNGSDITDKNLDFENQLFKVLNEFCRLLN
>NZ_CP050993.1|WP_066439493.1|2134173_2134920_-|PRTRC-system-protein-B
MRNTANTIENEEIDITNNFGTLYHPKSALVFYETEDYNPDGYVEHFDIDRNGNPINAHPLTVREAQRLSKMLNIQNKKDKDFLRPSGVISESILFIDTSENGKVVWYTKAQERHLLFTDKLSIPNGLAYLPPLVWCANKQGMKIFALETNQRPSEETPLFHAPFFNVYESGSVCMGTVDVKIKSSTSLEEFTNKWEDYFFNSYFSHLVNNHNPTKGNCVNLWKNLIQSKEVFPTDILINSNLTLKNLL
>NZ_CP050993.1|WP_168638732.1|2143742_2144873_-|hypothetical-protein
MAVPEKDLRLIRKEFENNDEINTERIRLGNGFVDDFILEGYEAADIPINALRVIFNIVSTISNEQFRPEDRPKQLSLFDEEFETENNIFASLKIRNSKISPSGSTKQVVDAYEFLTKFKMSWYKSTNSKGKEIKTFGGLISIPSYDQRGYTTFLISSYWLKKLMVIPQYNYVLYNLVYNIRNNKHIIFAIWLAKLPENGAVLKLSTLNKKFGLKYKTSKDFCFKFLKPARISLNTFNTLSFNYNYRGDSIFIIPYLTKTILNNNLSLNTREQLESNEAYLDHREKTAQRLSYIKKRYGLHENEMLQFSHQYRNVPQTRVLIEKAFKEFIRTARLNESKSTEFQGKLFLNEIQEHLIQIYRCTKMGELLPNGYPIII
>NZ_CP050993.1|WP_168638733.1|2144946_2145153_-|hypothetical-protein
MTLSDLKPGQKVTINGMLAEYKGIQKVKIPNFGKVEKRVFQGQGINIYKYYNLNEGAKTLVSEKIELI
>NZ_CP050993.1|WP_168638734.1|2145201_2145954_-|hypothetical-protein
MHHLELMQRFWDFNQKKSIGTTGISMYLYLLKIGSDNDSCDFQISDVVISIELGVTRKTVKSTKEKLRNLGLIQYQTTSGLACKYRLIGDYPSQISEPEMVRKKEIGKEESIQKTVESGVSLLTDRPVQNFSENTIDQEIESYLSQSIQSLQPQPTNQKGNDENIPSLEEFMTYAETLKIYEPELDSEIQSKYENWKKNGWKNSSDRPITNWRSSLKSTLPFMKSQTESHQLSLQSIPDIKRPKSQNGNL
>NZ_CP050993.1|WP_034976002.1|2145955_2146207_-|DUF3853-family-protein
MKNIDPKTPIWRLTVEEFLEVSKKINSEKKYEYGLKGLAKMLGCSISKASEIKSSGLLDDAIIQKGNIIIIDKEKALALFAQK
>NZ_CP050993.1|WP_066439471.1|2146213_2146756_-|hypothetical-protein
MKNNRNIIVFFERVIEDDRLYPSHISMYVSLFQFWSLNRFQNPFRISREDVMNLSKIRSIATYHKCIRELYRAGFIRYSPSYNSYKGSLIEIIDFDSEKVGEKKISHNQNFLPQDDIRFLVPVFNEVELYFTERDFPSAEADRFFSFYRSKNWKLSNEKPMKCWRAAARNWISALKNAIN
>NZ_CP050993.1|WP_066439470.1|2146772_2147036_-|helix-turn-helix-domain-containing-protein
MAISIITKEDLQQFKIELLEGIEILLKGKTTEQKLWLRSSEVKKLLNISSGTLQNLRINGTLSYSKIGGSLYYNYKDIQKLLSDVKH
>NZ_CP050993.1|WP_066439468.1|2147635_2148481_-|RteC-domain-containing-protein
MNGQNFKKKVDQLWKDLTTAVDQINRSENDIVIRAEEILMETDASIRQLKDLLRQYQFPDWSNEIYFFKNTKPQFVAVYIYYSKVLAVEASKPYADSQALRSYYENERSNLLYFYNEQREFISYYRRKSTYLDKKYFVRFKFDFKLKLSPELYSYDEEFSTSHDHIVSQIMANDLLEQYLTNKIDSKDSKENSIAHIKNLEWTAPKVALIELLYALHQTKCFNGGHSDLAEIFRWAENSLNIGLGNYHKTLSEIRLRKTDRTKFLSLLQQNFNQYLDDLDL
>NZ_CP050993.1|WP_168638735.1|2148532_2149174_-|helix-turn-helix-transcriptional-regulator
MLTDKIYSEYDKENLLEEKKQMIRGHQVILYSSIGAGLVILFFLIWRFRKREKELNARYQEVLEKLNTSKDTISFDVIAPASSDENILELYSSEIIEDIKTNLKIFEDEKQFLQQNLTLDIVAKMIGSNRTHLSYVLNVHFYVTFPTYLKALRIRYITNLLVEETIYLSYKIETLAKICGMANRQIFSAHFLEINSIRPRDFIRMRQEELKKT
>NZ_CP050993.1|WP_124986562.1|2149198_2150512_-|IS1380-family-transposase
MKFDLSFTNKEITPWGGMVFLKQMLDKIGFREQIEKCESLPVSLSNNSYKKEVLLESFITSIWCGANRFLHTEITRADKALGEIFDWRKTPAQDAYKRYFGKFTQHINQQVGHHFFSWFFQNLNLNYFTLDIDSSVITRYGEQEGAKKGYNPKKKGRNSHHPIIAFVNDVKMVANFWLRSGDTSSANNFVGFLEETLLNFGDKKVGLVRLDSGFFQKDIMDYLELKTLQYIIAAKFTHPIQHLIDQQDFWIKVDEGIEICDKYYQAKNWEKPRRIVIVRQKTAQRPNAAGRILSLFPEDEIHRNYRYSAYITNQEQSATDVWRTYRNRGDAENRIKELKADFGAESFNLKGFFPTEAALIFSMIAYNLMSIFRLFVLQEKTQKTLSTLRYRTFAIGAYFEKVGDTLKLKIALTKKRRKWFVGIWDYPIDLSQKISTA
>NZ_CP050993.1|WP_168638736.1|2150508_2151594_-|hypothetical-protein
MTQGKEIQQQSYKEISRLVDSYSENDERAMVFVKMYIDKAKNDHNHKKLIRGYEEAIYYSKETSRKLSYADSAIVTALKSNDQDQIARAYAGKGIIYYYNLRQYKKALEEYLIAFKYSKNSKDGYLKNKIIYHLGMIKSYLGYYKYAALHFEEAADFFEKNAKESLDRNIRYNNESGYFNSIYRLSTCYKNLKLYHKEDSLINIGLERLHNNSELVIEFGYFQKGKGAQLLRKGKADEALKHFKVSQDILSSNQDYASLTSVYFYIGKLYRSKGNRAESLNYFNKVDSLVNKFWFITPEIRSSYLYLIDDAKKNGDSERKMYFGDQLLKADSIINPNSAIEKKEYFSILISNCVAVEKNKR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP050993_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050993_6

2300753-2301046

orTypeII

Consensus_repeat	Method
ATTTCAATTCAAGTATTGTACGATTAAAAG	PILER-CR
ATTTCAATTCAAGTATTGTACGATTAAAAG	CRISPRCasFinder
ATTTCAATTCAAGTATTGTACGATTAAAAG	CRT

4 spacers

cas2,cas1,cas9

The CRISPR arrays of NZ_CP050993_6

>merge|NZ_CP050993|6|2300753-2301046|PILER-CR,CRISPRCasFinder,CRT
ATTTCAATTCAAGTATTGTACGATTAAAAGGATTAGGACACGATATTCTTTCAGAAGCTGAGAAAAATTTCAATTCAAGTATTGTACGATTAAAAGTGTTTTATGAGTTGTTCCGTGAACTCAAATAGTTCTTATTTCAATTCAAGTATTGTACGATTAAAAGTTTCTTTACTCGTCTAATAATGAAGGTTGATGATTAATTTCAATTCAAGTATTGTACGATTAAAAGAAATAGAAATAAAATGACAAATTTATTAAAAGCATATTTCAATTCAAGGATTGTAGGTGCTTTTA

>NZ_CP050993|6|1|2300753-2300981|PILER-CR
ATTTCAATTCAAGTATTGTACGATTAAAAG	GATTAGGACACGATATTCTTTCAGAAGCTGAGAAAA
ATTTCAATTCAAGTATTGTACGATTAAAAG	TGTTTTATGAGTTGTTCCGTGAACTCAAATAGTTCTT
ATTTCAATTCAAGTATTGTACGATTAAAAG	TTTCTTTACTCGTCTAATAATGAAGGTTGATGATTA
ATTTCAATTCAAGTATTGTACGATTAAAAG

>NZ_CP050993|6|6|2300753-2300981|CRISPRCasFinder
ATTTCAATTCAAGTATTGTACGATTAAAAG	GATTAGGACACGATATTCTTTCAGAAGCTGAGAAAA
ATTTCAATTCAAGTATTGTACGATTAAAAG	TGTTTTATGAGTTGTTCCGTGAACTCAAATAGTTCTT
ATTTCAATTCAAGTATTGTACGATTAAAAG	TTTCTTTACTCGTCTAATAATGAAGGTTGATGATTA
ATTTCAATTCAAGTATTGTACGATTAAAAG

>NZ_CP050993|6|1|2300753-2301046|CRT
ATTTCAATTCAAGTATTGTACGATTAAAAG	GATTAGGACACGATATTCTTTCAGAAGCTGAGAAAA
ATTTCAATTCAAGTATTGTACGATTAAAAG	TGTTTTATGAGTTGTTCCGTGAACTCAAATAGTTCTT
ATTTCAATTCAAGTATTGTACGATTAAAAG	TTTCTTTACTCGTCTAATAATGAAGGTTGATGATTA
ATTTCAATTCAAGTATTGTACGATTAAAAG	AAATAGAAATAAAATGACAAATTTATTAAAAGCAT
ATTTCAATTCAAGGATTGTAGGTGCTTTTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050993.1\|WP_168638831.1\|2308014_2312418_-\|DUF4011-domain-containing-protein	unknown	unknown	gnl\|CDD\|379066
NZ_CP050993.1\|WP_168638835.1\|2314190_2318480_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|375967
NZ_CP050993.1\|WP_168638828.1\|2301230_2304116_+\|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|316139
NZ_CP050993.1\|WP_168638824.1\|2296829_2297273_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168638833.1\|2312862_2313765_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|274694
NZ_CP050993.1\|WP_168638830.1\|2307685_2308063_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350195
NZ_CP050993.1\|WP_168638834.1\|2313772_2314219_-\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350259
NZ_CP050993.1\|WP_076554317.1\|2288429_2289770_+\|IS5-family-transposase	unknown	unknown	gnl\|CDD\|377531
NZ_CP050993.1\|WP_168639709.1\|2301057_2301180_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168638827.1\|2299026_2300259_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|369468
NZ_CP050993.1\|WP_168638829.1\|2306609_2307728_-\|DUF3320-domain-containing-protein	unknown	unknown	gnl\|CDD\|380141
NZ_CP050993.1\|WP_168638836.1\|2318882_2319086_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168638825.1\|2297306_2298149_+\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224995
NZ_CP050993.1\|WP_168638826.1\|2298167_2299019_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224278
NZ_CP050993.1\|WP_168638820.1\|2291153_2291909_+\|GLPGLI-family-protein	unknown	unknown	gnl\|CDD\|273495
NZ_CP050993.1\|WP_168638822.1\|2294555_2295209_-\|TraM-recognition-domain-containing-protein	unknown	unknown	gnl\|CDD\|378923
NZ_CP050993.1\|WP_168638832.1\|2312481_2312820_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NZ_CP050993.1\|WP_168638819.1\|2290810_2291140_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168638823.1\|2295233_2295629_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238624
NZ_CP050993.1\|WP_168638821.1\|2291886_2294559_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|372685

Protein	Function_ID	Function_description	E-value
NZ_CP050993.1\|WP_168638831.1\|2308014_2312418_-\|DUF4011-domain-containing-protein	gnl\|CDD\|379066	pfam13195, DUF4011, Protein of unknown function (DUF4011). This family of proteins is found in archaea and bacteria. Many members are annotated as being putative DNA helicase-related proteins.	2.08239e-50
NZ_CP050993.1\|WP_168638833.1\|2312862_2313765_-\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274694	TIGR03639, cas1_NMENI, CRISPR-associated endonuclease Cas1, subtype II/NMENI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.	8.36908e-96
NZ_CP050993.1\|WP_168638830.1\|2307685_2308063_-\|hypothetical-protein	gnl\|CDD\|350195	cd18808, SF1_C_Upf1, C-terminal helicase domain of Upf1-like family helicases. The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.	2.04067e-16
NZ_CP050993.1\|WP_168638834.1\|2313772_2314219_-\|PIN-domain-containing-protein	gnl\|CDD\|350259	cd18692, PIN_VapC-like, uncharacterized subfamily of the VapC-like nuclease family of the PIN domain superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.49234e-22
NZ_CP050993.1\|WP_076554317.1\|2288429_2289770_+\|IS5-family-transposase	gnl\|CDD\|377531	pfam05598, DUF772, Transposase domain (DUF772). This presumed domain is found at the N-terminus of many proteins found in transposons.	6.03473e-16
NZ_CP050993.1\|WP_168638835.1\|2314190_2318480_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|375967	pfam18541, RuvC_III, RuvC endonuclease subdomain 3. Cas9 proteins are abundant across the bacterial kingdom, but vary widely in both sequence and size. All known Cas9 enzymes contain an HNH domain that cleaves the DNA strand complementary to the guide RNA sequence (target strand), and a RuvC nuclease domain required for cleaving the noncomplementary strand (non-target strand), yielding double-strand DNA breaks (DSBs). The crystal structures of type II-A and II-C Cas9 proteins highlight the features in Cas9 enzymes that support their function as RNA-guided endonucleases. Cas9 enzymes adopt a bilobed architecture composed of a nuclease lobe containing juxtaposed RuvC and HNH nuclease domains and a variable alpha-helical lobe likely to be involved in nucleic acid binding. The RuvC domain forms the structural core of the nuclease lobe, a six-stranded beta sheet surrounded by four alpha helices, with all three conserved subdomains (I, II, III) contributing catalytic residues to the active site.	8.8048e-54
NZ_CP050993.1\|WP_168638827.1\|2299026_2300259_-\|MFS-transporter	gnl\|CDD\|369468	pfam07690, MFS_1, Major Facilitator Superfamily.	2.63985e-23
NZ_CP050993.1\|WP_168638829.1\|2306609_2307728_-\|DUF3320-domain-containing-protein	gnl\|CDD\|380141	pfam18741, MTES_1575, REase_MTES_1575. Vsr REase Fold. Fused to HEPN (SWT1/Abi2 family), along with Transglutaminase and wHTH.	1.95715e-27
NZ_CP050993.1\|WP_168638825.1\|2297306_2298149_+\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|224995	COG2084, MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism].	2.70717e-90
NZ_CP050993.1\|WP_168638826.1\|2298167_2299019_+\|hypothetical-protein	gnl\|CDD\|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	1.93541e-15
NZ_CP050993.1\|WP_168638820.1\|2291153_2291909_+\|GLPGLI-family-protein	gnl\|CDD\|273495	TIGR01200, conserved_hypothetical_protein, GLPGLI family protein. This protein family was first noted as a paralogous set in Porphyromonas gingivalis, but it is more widely distributed among the Bacteroidetes. The protein family is now renamed GLPGLI after its best-conserved motif.	5.09155e-33
NZ_CP050993.1\|WP_168638822.1\|2294555_2295209_-\|TraM-recognition-domain-containing-protein	gnl\|CDD\|378923	pfam12696, TraG-D_C, TraM recognition site of TraD and TraG. This family includes both TraG and TraD as well as VirD4 proteins. TraG is essential for DNA transfer in bacterial conjugation. These proteins are thought to mediate interactions between the DNA-processing (Dtr) and the mating pair formation (Mpf) systems. This domain interacts with the relaxosome component TraM via the latter's tetramerisation domain. TraD is a hexameric ring ATPase that forms the cytoplasmic face of the conjugative pore.	3.93767e-23
NZ_CP050993.1\|WP_168638832.1\|2312481_2312820_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	6.52259e-21
NZ_CP050993.1\|WP_168638828.1\|2301230_2304116_+\|T9SS-type-A-sorting-domain-containing-protein	gnl\|CDD\|316139	pfam13583, Reprolysin_4, Metallo-peptidase family M12B Reprolysin-like. This zinc-binding metallo-peptidase has the characteristic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.	4.5644e-33
NZ_CP050993.1\|WP_168638823.1\|2295233_2295629_+\|amidohydrolase-family-protein	gnl\|CDD\|238624	cd01299, Met_dep_hydrolase_A, Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	1.80372e-29
NZ_CP050993.1\|WP_168638821.1\|2291886_2294559_+\|TonB-dependent-receptor	gnl\|CDD\|372685	pfam13715, CarbopepD_reg_2, CarboxypepD_reg-like domain. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.	9.08362e-07

>NZ_CP050993.1|WP_168638827.1|2299026_2300259_-|MFS-transporter
MTSNKQLNFLKSPFFIPWILALLFYALEYGVRSSPSVMIPQLTGNFNLSTTEVSAIISAYYITYSVGSLAAGLLLDRIGAKHPLAIGIIILALGCVLFISSNYFWGYTGRLLQGLGSAIAFPASVFLAVKAFSGKNLATAIGVTQTLGMLGGSAGQKLSNSYLTSGNSYNSLWIIFGVSSLVLGVLAFVFTPKTNTDEFTEVRKQPLLANYKIVFSNWQSWLCGFASGLLFAPTTIFAMIWGVDFLEQARHLTHGQATVACALVPIGWAIGCPLFGWLADKFEKRIPVLAGGAVVMILCLLQLAFLPHLMGPGMSLFFMGVGSGAAMLPYSTIKEVNPDKVKGSATGAINFLVFGVTSLLSPVFTHLFASKLDMAVNKNAIFQQSCFFFIIAIGIAIFLCTFLRETGKEK
>NZ_CP050993.1|WP_168638826.1|2298167_2299019_+|hypothetical-protein
MKKAILMTVLISALSVSQTITAQMPTPTPNNISLEYQLEKEAAGIAVSDDHRVFIALPRGGENHQLPSVVEMVGQKMIAFPNEEINKNTNSDYNSHLVSILGITIYKNTLWILDQGKRAGVDGIPDGSTKVVAVDINSKKVIKNIPIPKPFFRETIQLNDLRFDPTHGKEGTIYISNNGFAKPDQSLIVMDVATGKLRELFKDIPEVSPAKGFISYVDHKEQGCVQYDLHQDQDRPEVFFFYERWESREILEQHLKTDHLNTWGDQQKELLAAPMEVFIMDKL
>NZ_CP050993.1|WP_168638825.1|2297306_2298149_+|NAD(P)-dependent-oxidoreductase
MSTEKLGFIGLGNMGHPMAKNLEKAGFPLFVYNRTEEKAEDFRSKSTVCQSVADLVNEADIIFTMLTNDQAVEAVYKDILKNDLSGKLFVDMSTISQKVSREVGDAVKIEEAHFIDAPVAGSTKPAAEGTLIIMVGGENDDVQRATPYLEKLGKIKHLGENGKGLAAKISINYFLAMIYEGLAETVLLSDKLGIDRKAMLEIINESASGSGATKVKTPLLLDDNFAPAFALDLMLKDIRLAKDAGADYPTGTSILKTYTEASEKGFGKDDVIGIINYLKK
>NZ_CP050993.1|WP_168638824.1|2296829_2297273_+|hypothetical-protein
MNLSYLAGVWYIVLSNFPMWTKGDKIKPNFNYNIETKNGIRGLSDEVKFLKNGKTKSIKGWDRPTDQENTKFIWRGSGLLSIAKSQWEILYRSEDFSWMVIHFEKTLFTPEGYDVVCKDPKDFLRNKDLIFKKLTELKITGLQEIPQ
>NZ_CP050993.1|WP_168638823.1|2295233_2295629_+|amidohydrolase-family-protein
MSLKNSPLFETNIKAFQTSLKNVKRVYDAGIPVAFGTDSGAMFLRAQGFSEHLELQLLVEAGLTPNQAITIATKNAAKAIGIDKDFGTLEVGKTADFLILDANPLNNIKNTEKINALYKAGKLVSKGPLAQ
>NZ_CP050993.1|WP_168638822.1|2294555_2295209_-|TraM-recognition-domain-containing-protein
MGNDSTLPQVYAPIISLIISVGMRQMNKPRQQKSVVLLDEAPTIYIPNIEQIPATARSNKIATIFGVQDFSQLVDNYGEDKAQIIISNLGNQFFGRVTNGRTAEMVGKLFSKEDRTYINKNTGTGTSGQLVHTQSNQSSGKSESIQERDRVKVSDLINLNTGEFYGIIAEGQPKEFFKTQFLTDFAESRENDKRAVTDMEMQENYYRIIEEAKRIVI
>NZ_CP050993.1|WP_168638821.1|2291886_2294559_+|TonB-dependent-receptor
MSGKMLSNYIKKISHLFFLLIFINSYSQITIKGSVFSNSEPIYHANIVLLDNQNQIETFVFSNQDGSFSLNTQFRGIGKIKVSAPGFVNVEKEIHIKTESIDISKINLKESVKEIEEVIIKNKNPITVKKDTIEYKAASFANGTENNLEDLLKKLPGIDIDKDGKIKIGQKSIEKVLIENDDLFEKGYQILTQNMPSAPIEKIQVISKYSKNKLLKNIENSEAMVLNITLKDKSSNRWMGSYHIASSSYIEKLRQLKVNLMNFSKKKKIYLLFNTNNIGINEMKGVEYFIKNSTENSVENIGNIENSTKIINLHVYNSLFEEKRTNFNNDYLGAFNYIKNYEGGYHLKIAGIYNKIGNENQINSVYNFDYNGLKFSNKEEKIWKLKQQNIVTKIELIKDFKNNSSINFYNKLSWINNNNDNNFIFNNDYNPQQGLNKIFSNENKLVFTKKIDSSTAIVGVGRFMLQDRPYLLTEKNNLVQKIFNHPTAEFLQQDIDSKYSYGGFKISYIKSLDKHNIELPIGAENQRDKLTSKIQLLDSSQNQVWINEDKIFSNNLEVVKTNFFINPTYQYKVEKWKVKLSGNTSFLNIKSYDKNTFKDFLFSPTFTVRYENKSTGNFALEYIKTFSNTEITDMYNGYIYLGNRIFAKSNTDFNLLPNYSINFDYQLGNVLKESMSFNINYLHNNDYISSNFIVNPDYTFNQKIILKNNYYLNVNLELKKYINLINSRFSLINKLSKSSYENSVNDSRIQKTKSTNYTLGFELKSGWLKSVNYELGYNWVFNYLTSANNKRDYINQNGYFNLYYNLSSKLFIDSNIEYYLFGQSNQKHTTFVDLKASYKLIDSKMNIFIQGRNLLNTKYISGYSINNVSESFYTQKLLPLSILIGFNKNF
>NZ_CP050993.1|WP_168638820.1|2291153_2291909_+|GLPGLI-family-protein
MKKQLCLILLFCLVLLKAQDNFILYNKITDDTGQTKASQNYLLSYKNNSSIFCFYKDDIAKDLKSFLSENIPLRGSEIIRNTGKNFEIRSTGFTKEPLYTIDNYQDFNWVISKKDVKDIMGYKCFKATGKFRGRTYIAWFTPDLPNDIGPWKFRGLPGIILSISDTDNIFTFQAIEIHLNAINKFPISERVNFDKNQNYISYKDFINKENSHINDMRKRIEANRSTGTVVLSRSNNRDFKIEKSFEWENAK
>NZ_CP050993.1|WP_168638819.1|2290810_2291140_+|hypothetical-protein
MKKFLFTAVLLAGTTLGFAKDNAQNEVLAVSNESATTTVVIENKEAEKAEDIFSCTMSFITREYNNCGEYQGSYVDSIELPSALCGDMDNGIIMHVSNMNNGFGDCWNG
>NZ_CP050993.1|WP_076554317.1|2288429_2289770_+|IS5-family-transposase
MLGKIKQDLQQNLFKTRLTELINMDHPLVKLAHEISWDKIEAEFEGLFSKEGRPSIAVRKIAGMLLLKEMFKESDESVVERWIENAYWQYFTGEDFFQTEQPFDPSNFVHFRKRIGERGLEFLLGQSVSLHPKAKTEDEVQIDTTVQEKNITFPTDAKLAKKVIDNCVKIAEKEGVVQRQSYKRVSKQLLRSAYFGHHPKRQKNARMARKKLRTIGKRLLRELERKLPESVLKDYREIFAIYLKALTQEKTTKDKIYSLHESQVACIAKGKSGKNYEFGTKVAVVRGRKTGIISSVKRFSGNPHDSKTLEESLSQSERVRKSVGGTRPKKAATDRGFRGIKEVEGTLILLPTKKEKTRYGQQVARLRFRARAAIEPCISHLKRNHSLGLNFLKGVAGDIHNALLAGIGYNLKMRLNQIKQQILFWLEVVLKIFLGKYNFQNEKLAF
>NZ_CP050993.1|WP_168639709.1|2301057_2301180_+|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MGTYVLGWGDVDSFWSPRSWLLAIGGSVLLLFIYSMLTKK
>NZ_CP050993.1|WP_168638828.1|2301230_2304116_+|T9SS-type-A-sorting-domain-containing-protein
MKKIFTTLLSFGMVAGALAQWTPTAMKGENLRQNGATKFYSLDVNAIRTQLQNAQLTGKESKPVIISVPTLNGKIERFKVYSLPVVVQSLADRYQLGSYVGTGVDDPEKYIRFSVAPDDFQSMIIKNGVYEFVEPQNKEKTVYGVHPKTNKTSGASGYWLCNSTEPLVTKKEIEKLANGSNFTNSATDFSKASDKKYRTMRLAMSVNGEYTAYHGGTVAGALTAINATLTRCNGIFENDFALHLILQDFPSVIYTDASTDPYSTNLNEWNQQLQTTLTTNVGNDNYDIGHMFGASGGGGNAGCIGCVCINPTTTTPLGKGSGITSPADGIPQGDNFDIDFVAHEMGHQLGANHTFSMSLEGTGQNVEPGSGSTIMGYAGITGATDVQAHSDPYFHINSIIQVQDNLTSKTCDIETAVANQPPVIVAMPDITIPKSTAFVLTAQATDAEGNPITYCWEQTDSATSTTSTSNLGNNTNGPTFRSWNPTTEPVRYFPKLSTVLAGNLKSTTDWEAVSTVARTTNYKVTVRDNNPDKTQQQTQYGTQRVVVGTAGPFKVTSTKVYNNGVAAFTWDPVGTTAAPYNVANVKIDYTTDNGNTWTVLAASTPNDGTEELNFNTFATNSQLTIRVSALGNVFYAVGKVTVSEMMNCNGTAPAGLAASEISQTGAKIDWDAVANATYTLRYKKAADTNWTEVNNLTTNTYTISGLELSTAYDVSVANVCSGSTGAYATTNFTTKDIEYCTAEASSTSYEKISNVTFAGINNNSTSTAGYEDFTAVTGNVNAGQTYNFSASFSGASYDEDQVLVWIDLNQDGDFDDAGERVLVTTAKKSPWTGSIAIPATAKIGQTRMRVRLQDTSSGPNATPCGTSDYGQVEDYTLNVGQLAVSDVKKNSVNVYPNPAKDIINISNVSSKAQFEIYSVGGQLVNQGITDGKVNVSKLTKGVYILTVESNGEKSQTKFIKN
>NZ_CP050993.1|WP_168638829.1|2306609_2307728_-|DUF3320-domain-containing-protein
MHLFATLQTDQIDLSRTSAEGVAGLKAFLHFAEKGHLSIRPEDIQETRNKQHLSETISKRLKEKGVEVKCNIGTSGFKVDIGIVHPDKPEQYILGIVVDGHYYYNARTTNDREMVMPSVLKALGWNIHRVWTIDWYENSEKIVDTIIEKVKQLQTRSEDYEEKITEPVVLPEFEPIKAMPDAPINTVSMQKPYIAHILIPVPNANSETIYEFQNRNIIRQQIQSLVDTEAPVSKGLLYRKVLQIWNTSRVGAKLDRYLEGIIKEMNLVQTVHHQPFYWSNGTALNYYRINDTEKRNMEDIAPEEILVALQEVITDNLSIEEDELLRYLARTFGFAKLGKQIDAILRYTVDLAEKENIVKKENGRIILTIPKE
>NZ_CP050993.1|WP_168638830.1|2307685_2308063_-|hypothetical-protein
MEFIKSHYNNSQKRKLSLGVVTFSQTQQNLIEDKLQKLFMSDPRLEEFAHESDEPLFVKNLENVQGDERDIILFSICYAPDEEGKMSMNFGPLNRNGGWRRLNVAVTRAVMKCIFLLHCRRIRSI
>NZ_CP050993.1|WP_168638831.1|2308014_2312418_-|DUF4011-domain-containing-protein
MEQNATLIIHKQTLPFLNISLYLNGIKPVQSLILENTSEKDTSPLEVNITADLPCVEPFRYTVPFIPAQKGIKIPLENLKFNRDFINRLSETEKANITIGITGENAITINEIFELDIHPLEYFGGFQILPELIAAYVTPNHPYIYHLKRKAVEILEKQNLKTAFEGYQANDPERVLQMMSAIYSAVQNEGIVYSALPPGYEATGQRLRLLNTIQQEKFGNCIDLSLLFAACLEAIDLNPILILVKGHAFVGCWLQDDKFSEVINDDKTAITKRLSKGIREMAAFEATSICKGNNLKFSDALNAGEAQLVQQEDFLLSVDIKRARTLRIRPLPLLTNVSEIQLDEEIIRQTETAEMENHFELGTIYQDDLLQGNKPKTKQKIWERKLLDLSLRNNLLNLRMTRNMLQLVDIDISNLEDTLSEGKSFSVIPNPNAEVLRKYNLFTQPLHSSSPLYQLANDELKYNRLLTHYHQQDLDSILTYIHKNAKQAIEESGSSTLYLAVGLLKWFDRKTPDQPRYSPVLLLPVEISRRSVNSKFILKSREEETMINITLIEFLRQEYELNLSALEQLPYDEKGVDVAKVMGILRRAVMQLKGWDVEEQLVLGNFSFSKLILWKDIVAHQEDLLKSDMVRSLVEGKLSFSENYETISASDFDNIHSQSLALPIPTDVSQMEAVLTAQQGHSFILHGPPGTGKSQTITNIIADALYHGKRVLFVAAKKAALDVVQRRLEQIGLAPFTLELHSNKSKKSDVLEQLAKSIETAKLVRTADFEQEAQRLDAAKKAISDYVNILHQKQQVGWSLYDSITALENDHDENFPKNFIPEEVLQQLDAALWQQWTDWIPQFQSVVKFIIHPSENPLSAFNLPHYSPVVNDEIAKQTQQLLQLLPDVQSKLKSLASAIHFPFSVQTKTEWGQFIQVIDSLQNLPDIPLELILYLSDKENYQMYEEWKSAFQQYQNSLNNILKNYKRNVLNTDISATEVQWKKAQQSWFLPKWLKSGKIKKELTAFRNAAFTNDHEVEQLFSDNNQLQEAQRLLQQRRFAELQKALKNLYKDEQTDLGDIDKKATFTQHLSNITNIWGRNALGQWIQILQQENMQYSDEIKQKHSTLIDEFLQLTAIFNEQEKNYGTLTGTNFQQKENWLERTVAQLQDIQENLPQLKNWMNYVQLRNQGEDLHLKWLINAYENKVCNAENISDYFYYAVHASVVQHVISQHESLSLFNAGLFESKVEQYKKIAKEFQALTIQELRVKLAAQLPNTTAEAMQSSEIGILQRAIKNRGRGLSIRKLFDQIPALLPRIAPCMLMSPISAAQYFDVDASHFDMVIFDEASQLPTCEAVSALARAKQAVIVGDPKQMPPTSFFSSVKLDEENMDVEDLESILDDCLSLSVPSKYLLRHYRSKHESLIAFSNVNYYENKLLTFPSADDLNRKVKFHHIEGFYDKGKTRTNKFEADALWNSSNLITIIHRNGN
>NZ_CP050993.1|WP_168638832.1|2312481_2312820_-|CRISPR-associated-endonuclease-Cas2
MNAERFNAYRIMWVLVLYDLPTETKANMKDANRFRKALLDDGFTLFQFSMYVRHCPSRENAEVHIKRVKFMLPKAGKVAIMCITDKQFGDIEIFFARNKEEPPPTFQQLELF
>NZ_CP050993.1|WP_168638833.1|2312862_2313765_-|type-II-CRISPR-associated-endonuclease-Cas1
MITRSIYIGNPAYLKLKDGQMYILCPETKQAKGKVPVEDLGLLMLDHFQITLSHQLIQKMMGNNVVVVSCDDHHLPHGIMLPLYGHTEHSDRVKDQLEASEPLKKQLWKQTIECKIENQKEVLRRLGNYYEPMLDYQNNVKSGDSTNMEGIAAQHYWKYLISLDFLRQRLGDSPNQFFNFGYAVLRSIVARAIVETGLLPVLGIFHKNKYNPYCLADDLMEPYRPFIDLLVMQWLKINPDTEELNKEFKAHILQIATKDVMIDDKTRPLLVAVKTTATSLYKCYTGEKRLISYPELIGIG
>NZ_CP050993.1|WP_168638834.1|2313772_2314219_-|PIN-domain-containing-protein
MISEKFSSDKDNDFKKIKYSIDTNILVYAYEKSNHAISETAINLINQEANISNYAYQEFLFNLKEKGLLKGEISKMGIELLNILNLNRIDKDTYRYAHYLMIKHNFQLGDSIVIADAILNNCNVLYSQDDMGHHGLVDKKLRIINPFK
>NZ_CP050993.1|WP_168638835.1|2314190_2318480_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MTKNILGLDLGTNSIGWALIQQDFQNKQGEILGMGSRIIPMSQDVLGDFGKGNSVSQTASRTGYRGVRRLRERFLLRRERLHRVLNILNFLPEYYASQIDFEKRFGKFREETEPKLAYSKEGFIFKNSFEEMLTDFKNHQPQILQNDKKVPYDWTIYYLRKKALSQKIEKEELAWILLNFNQKRGYYQLRGEDFEEEKDKMFVRLKVDRIVDSGENVKGKILYDVYFDNGWKYDKQIVKTEDWIERVKEFIVTESFLKNGDIKRTFKAVDSEKDWIAIKTKIEQEIDNSDKTVGTYIYETLLQNPKQKIKGKLVRTIERKFYKEELKQILETQKEFHPELNNESLYNDCVRELYRNNEAHQLTLSKKDFVHLFMDDIIFYQRPLRSQKSSISNCSLEFRKYKDENGVEHTQYLKAIPKSNPYYQEFRIWQWIYNLNIYKKEDDANVTKEFLNTTKDYENLFEFLNNRKEVDQKALLKHFKLNDKTHRWNFVEDKKYPCNETKTMIYERLKKVENISNDFLTREIEQKIWHIIYSVNDKIEYEKALKSFARKNHLDENSFFEAFKKFPPFKNEYGSFSEKAIKKLLPLMRLGKYWNYADIDKYSRERIQKIITGEYDENIKDKVREKAVHLTTENDFQGLQLWLAQYIVYGRHSEASMIGKWNSADDLEEFLKEFKQHSLRNPIVEQVITETLRVVKDIWMKYGNGAKDFFDEIHIELGREMKLPAEERDRLTRQISENENTNLRIKALLAEMMNDGAVENVRPYSPMQQEILKIYEDGVLNSGIEIEDEYLKISKTAQPSSSDLKRYKLWLEQKYKSPYTGQIIPLNKLFTPEYEIEHIIPQSRYFDDSFSNKIICESAVNKLKDNYIGFGFIKQFGGTIVECGFGKSVKVFESEEYEDFIKKHYANNRSKRNKLLLEDIPEKMIERQMNDTRHISKYISGILSNIVRVEDGTDEGVNSKNIVPGNGKITTQLKQDWGLNDVWNDLILPRFERMNQLTNSNDFTAWNENHQKFLPTVPIEYSKGFSKKRIDHRHHAMDALVIACATKDHVNLLNNQSAKSDTKRYDLKKKLMKFEKVVYNHPQTGDRIEREVPKQFFKPWDNFTVGAKNSLEKIIVSFKQNLRVINKATNHYEKYVEKDGVKTKERVEQTGTNWAIRKPMHKETVSGKVDLPWVKVPKGKILTATRKSLDTSFDLKTINSITDTGIQKILKNYLEFKGSPELAFSPEGIEDMNKNIEKYNDGKPHQPINKVRIFELGSKFPLGQSGNKKDKYVEAAKGTNLFFAVYEGKNEKRSYETIPLNIVVERQKQGLLACPETNEKGERLLFYLSPNDLVYLATEEENDIAPSINFNNINKEQINNLYKIVSFTGNRLYAIPLSVATTIVNKVEYTQLNKIEFTKEKEFLLKLNVNRLGDVKTFTANDIRKIFIG
>NZ_CP050993.1|WP_168638836.1|2318882_2319086_-|hypothetical-protein
MAPKLTRLCIYPKDIQLITGRSERHCREIMYIIRRSLNKQDHQFITIDEFCTWAGLDPAAVRQILHN

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Crispr_ID: NZ_CP050993_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050993_7

2305645-2306466

orTypeII

Consensus_repeat	Method
TTATTGTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	PILER-CR
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	CRISPRCasFinder
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	PILER-CR

10 spacers

cas2,cas1,cas9

The CRISPR arrays of NZ_CP050993_7

>merge|NZ_CP050993|7|2305645-2306466|PILER-CR,CRISPRCasFinder,PILER-CR
TTATTGTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAACTAATAACAAAAAGGTATAATGTACCTTTTTGTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAACCTATTGAGCTGGTGAAGCAAATGCAGGAATGTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAACAATATCGCCGTAAAGGCAAATTAATTGGCTGTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAACTAGGATATGTTTATCCTGATGCACGAAGTAGTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAACGAAGCAGCTCAAAGAGACTACAGGAACTACGTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAACGCTGCGCAGCTTGTAATTATTTCGAATCTTGTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAACAACTCGAGATAACATTTGTAAAAAAACATAGTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAACTAAAAAATATTGCAAAAGTAGGCGATTCCGGTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAACAAGCTTATTTACTTGATATGGCTACACCTAGTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAACATGTTCAACGTTCAACCTTACGATTATCGCGTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC

>NZ_CP050993|7|2|2305645-2305850|PILER-CR
TTATTGTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	TAATAACAAAAAGGTATAATGTACC
TTTTTGTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	CTATTGAGCTGGTGAAGCAAATGCAGGAA
TGTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAACAATATCGCCGTAAAGGCAAATTAATTGGCTGTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAACTAGGATATGTTTATCCTGATGCACGAAGTAGTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	GAAGCAGCTCAAAGAGACTACAGGAACTAC
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	GCTGCGCAGCTTGTAATTATTTCGAATCTT
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	AACTCGAGATAACATTTGTAAAAAAACATA
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	TAAAAAATATTGCAAAAGTAGGCGATTCCG
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	AAGCTTATTTACTTGATATGGCTACACCTA
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	ATGTTCAACGTTCAACCTTACGATTATCGC


>NZ_CP050993|7|7|2305650-2306466|CRISPRCasFinder
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	TAATAACAAAAAGGTATAATGTACCTTTTT
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	CTATTGAGCTGGTGAAGCAAATGCAGGAAT
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	AATATCGCCGTAAAGGCAAATTAATTGGCT
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	TAGGATATGTTTATCCTGATGCACGAAGTA
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	GAAGCAGCTCAAAGAGACTACAGGAACTAC
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	GCTGCGCAGCTTGTAATTATTTCGAATCTT
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	AACTCGAGATAACATTTGTAAAAAAACATA
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	TAAAAAATATTGCAAAAGTAGGCGATTCCG
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	AAGCTTATTTACTTGATATGGCTACACCTA
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	ATGTTCAACGTTCAACCTTACGATTATCGC
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC

>NZ_CP050993|7|3|2305958-2306466|PILER-CR
	TAATAACAAAAAGGTATAATGTACC
TTTTTGTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	CTATTGAGCTGGTGAAGCAAATGCAGGAA
TGTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAACAATATCGCCGTAAAGGCAAATTAATTGGCTGTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAACTAGGATATGTTTATCCTGATGCACGAAGTAGTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	GAAGCAGCTCAAAGAGACTACAGGAACTAC
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	GCTGCGCAGCTTGTAATTATTTCGAATCTT
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	AACTCGAGATAACATTTGTAAAAAAACATA
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	TAAAAAATATTGCAAAAGTAGGCGATTCCG
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	AAGCTTATTTACTTGATATGGCTACACCTA
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC	ATGTTCAACGTTCAACCTTACGATTATCGC
GTTGTGAATTGCTTTCATTTTTGAGTATCTTTGAGATATCACACAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050993.1\|WP_168638831.1\|2308014_2312418_-\|DUF4011-domain-containing-protein	unknown	unknown	gnl\|CDD\|379066
NZ_CP050993.1\|WP_168638835.1\|2314190_2318480_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|375967
NZ_CP050993.1\|WP_168639709.1\|2301057_2301180_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168638833.1\|2312862_2313765_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|274694
NZ_CP050993.1\|WP_168638830.1\|2307685_2308063_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350195
NZ_CP050993.1\|WP_168638834.1\|2313772_2314219_-\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350259
NZ_CP050993.1\|WP_168638826.1\|2298167_2299019_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224278
NZ_CP050993.1\|WP_168638824.1\|2296829_2297273_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168639710.1\|2319409_2319922_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378161
NZ_CP050993.1\|WP_168638820.1\|2291153_2291909_+\|GLPGLI-family-protein	unknown	unknown	gnl\|CDD\|273495
NZ_CP050993.1\|WP_168638829.1\|2306609_2307728_-\|DUF3320-domain-containing-protein	unknown	unknown	gnl\|CDD\|380141
NZ_CP050993.1\|WP_168638836.1\|2318882_2319086_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168638825.1\|2297306_2298149_+\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224995
NZ_CP050993.1\|WP_168637941.1\|2320571_2321918_+\|IS5-family-transposase	unknown	unknown	gnl\|CDD\|377531
NZ_CP050993.1\|WP_168638827.1\|2299026_2300259_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|369468
NZ_CP050993.1\|WP_168638822.1\|2294555_2295209_-\|TraM-recognition-domain-containing-protein	unknown	unknown	gnl\|CDD\|378923
NZ_CP050993.1\|WP_168638832.1\|2312481_2312820_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NZ_CP050993.1\|WP_168638828.1\|2301230_2304116_+\|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|316139
NZ_CP050993.1\|WP_168638823.1\|2295233_2295629_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238624
NZ_CP050993.1\|WP_168638821.1\|2291886_2294559_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|372685

Protein	Function_ID	Function_description	E-value
NZ_CP050993.1\|WP_168638831.1\|2308014_2312418_-\|DUF4011-domain-containing-protein	gnl\|CDD\|379066	pfam13195, DUF4011, Protein of unknown function (DUF4011). This family of proteins is found in archaea and bacteria. Many members are annotated as being putative DNA helicase-related proteins.	2.08239e-50
NZ_CP050993.1\|WP_168638833.1\|2312862_2313765_-\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274694	TIGR03639, cas1_NMENI, CRISPR-associated endonuclease Cas1, subtype II/NMENI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.	8.36908e-96
NZ_CP050993.1\|WP_168638830.1\|2307685_2308063_-\|hypothetical-protein	gnl\|CDD\|350195	cd18808, SF1_C_Upf1, C-terminal helicase domain of Upf1-like family helicases. The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.	2.04067e-16
NZ_CP050993.1\|WP_168638834.1\|2313772_2314219_-\|PIN-domain-containing-protein	gnl\|CDD\|350259	cd18692, PIN_VapC-like, uncharacterized subfamily of the VapC-like nuclease family of the PIN domain superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.49234e-22
NZ_CP050993.1\|WP_168638826.1\|2298167_2299019_+\|hypothetical-protein	gnl\|CDD\|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	1.93541e-15
NZ_CP050993.1\|WP_168638835.1\|2314190_2318480_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|375967	pfam18541, RuvC_III, RuvC endonuclease subdomain 3. Cas9 proteins are abundant across the bacterial kingdom, but vary widely in both sequence and size. All known Cas9 enzymes contain an HNH domain that cleaves the DNA strand complementary to the guide RNA sequence (target strand), and a RuvC nuclease domain required for cleaving the noncomplementary strand (non-target strand), yielding double-strand DNA breaks (DSBs). The crystal structures of type II-A and II-C Cas9 proteins highlight the features in Cas9 enzymes that support their function as RNA-guided endonucleases. Cas9 enzymes adopt a bilobed architecture composed of a nuclease lobe containing juxtaposed RuvC and HNH nuclease domains and a variable alpha-helical lobe likely to be involved in nucleic acid binding. The RuvC domain forms the structural core of the nuclease lobe, a six-stranded beta sheet surrounded by four alpha helices, with all three conserved subdomains (I, II, III) contributing catalytic residues to the active site.	8.8048e-54
NZ_CP050993.1\|WP_168639710.1\|2319409_2319922_-\|hypothetical-protein	gnl\|CDD\|378161	pfam09357, RteC, RteC protein. Human colonic Bacteroides species harbor a family of large conjugative transposons, called tetracycline resistance (Tcr) elements. Activities of these elements are enhanced by pregrowth of bacteria in medium containing tetracycline, indicating that at least some Tcr element genes are regulated by tetracycline. An insertional disruption in the rteC gene abolished self-transfer of the Tcr element to Bacteroides recipients, indicating that the gene was essential for self-transfer.	3.79489e-52
NZ_CP050993.1\|WP_168638827.1\|2299026_2300259_-\|MFS-transporter	gnl\|CDD\|369468	pfam07690, MFS_1, Major Facilitator Superfamily.	2.63985e-23
NZ_CP050993.1\|WP_168638829.1\|2306609_2307728_-\|DUF3320-domain-containing-protein	gnl\|CDD\|380141	pfam18741, MTES_1575, REase_MTES_1575. Vsr REase Fold. Fused to HEPN (SWT1/Abi2 family), along with Transglutaminase and wHTH.	1.95715e-27
NZ_CP050993.1\|WP_168637941.1\|2320571_2321918_+\|IS5-family-transposase	gnl\|CDD\|377531	pfam05598, DUF772, Transposase domain (DUF772). This presumed domain is found at the N-terminus of many proteins found in transposons.	1.63944e-16
NZ_CP050993.1\|WP_168638825.1\|2297306_2298149_+\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|224995	COG2084, MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism].	2.70717e-90
NZ_CP050993.1\|WP_168638820.1\|2291153_2291909_+\|GLPGLI-family-protein	gnl\|CDD\|273495	TIGR01200, conserved_hypothetical_protein, GLPGLI family protein. This protein family was first noted as a paralogous set in Porphyromonas gingivalis, but it is more widely distributed among the Bacteroidetes. The protein family is now renamed GLPGLI after its best-conserved motif.	5.09155e-33
NZ_CP050993.1\|WP_168638822.1\|2294555_2295209_-\|TraM-recognition-domain-containing-protein	gnl\|CDD\|378923	pfam12696, TraG-D_C, TraM recognition site of TraD and TraG. This family includes both TraG and TraD as well as VirD4 proteins. TraG is essential for DNA transfer in bacterial conjugation. These proteins are thought to mediate interactions between the DNA-processing (Dtr) and the mating pair formation (Mpf) systems. This domain interacts with the relaxosome component TraM via the latter's tetramerisation domain. TraD is a hexameric ring ATPase that forms the cytoplasmic face of the conjugative pore.	3.93767e-23
NZ_CP050993.1\|WP_168638832.1\|2312481_2312820_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	6.52259e-21
NZ_CP050993.1\|WP_168638828.1\|2301230_2304116_+\|T9SS-type-A-sorting-domain-containing-protein	gnl\|CDD\|316139	pfam13583, Reprolysin_4, Metallo-peptidase family M12B Reprolysin-like. This zinc-binding metallo-peptidase has the characteristic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.	4.5644e-33
NZ_CP050993.1\|WP_168638823.1\|2295233_2295629_+\|amidohydrolase-family-protein	gnl\|CDD\|238624	cd01299, Met_dep_hydrolase_A, Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	1.80372e-29
NZ_CP050993.1\|WP_168638821.1\|2291886_2294559_+\|TonB-dependent-receptor	gnl\|CDD\|372685	pfam13715, CarbopepD_reg_2, CarboxypepD_reg-like domain. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.	9.08362e-07

>NZ_CP050993.1|WP_168638828.1|2301230_2304116_+|T9SS-type-A-sorting-domain-containing-protein
MKKIFTTLLSFGMVAGALAQWTPTAMKGENLRQNGATKFYSLDVNAIRTQLQNAQLTGKESKPVIISVPTLNGKIERFKVYSLPVVVQSLADRYQLGSYVGTGVDDPEKYIRFSVAPDDFQSMIIKNGVYEFVEPQNKEKTVYGVHPKTNKTSGASGYWLCNSTEPLVTKKEIEKLANGSNFTNSATDFSKASDKKYRTMRLAMSVNGEYTAYHGGTVAGALTAINATLTRCNGIFENDFALHLILQDFPSVIYTDASTDPYSTNLNEWNQQLQTTLTTNVGNDNYDIGHMFGASGGGGNAGCIGCVCINPTTTTPLGKGSGITSPADGIPQGDNFDIDFVAHEMGHQLGANHTFSMSLEGTGQNVEPGSGSTIMGYAGITGATDVQAHSDPYFHINSIIQVQDNLTSKTCDIETAVANQPPVIVAMPDITIPKSTAFVLTAQATDAEGNPITYCWEQTDSATSTTSTSNLGNNTNGPTFRSWNPTTEPVRYFPKLSTVLAGNLKSTTDWEAVSTVARTTNYKVTVRDNNPDKTQQQTQYGTQRVVVGTAGPFKVTSTKVYNNGVAAFTWDPVGTTAAPYNVANVKIDYTTDNGNTWTVLAASTPNDGTEELNFNTFATNSQLTIRVSALGNVFYAVGKVTVSEMMNCNGTAPAGLAASEISQTGAKIDWDAVANATYTLRYKKAADTNWTEVNNLTTNTYTISGLELSTAYDVSVANVCSGSTGAYATTNFTTKDIEYCTAEASSTSYEKISNVTFAGINNNSTSTAGYEDFTAVTGNVNAGQTYNFSASFSGASYDEDQVLVWIDLNQDGDFDDAGERVLVTTAKKSPWTGSIAIPATAKIGQTRMRVRLQDTSSGPNATPCGTSDYGQVEDYTLNVGQLAVSDVKKNSVNVYPNPAKDIINISNVSSKAQFEIYSVGGQLVNQGITDGKVNVSKLTKGVYILTVESNGEKSQTKFIKN
>NZ_CP050993.1|WP_168639709.1|2301057_2301180_+|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MGTYVLGWGDVDSFWSPRSWLLAIGGSVLLLFIYSMLTKK
>NZ_CP050993.1|WP_168638827.1|2299026_2300259_-|MFS-transporter
MTSNKQLNFLKSPFFIPWILALLFYALEYGVRSSPSVMIPQLTGNFNLSTTEVSAIISAYYITYSVGSLAAGLLLDRIGAKHPLAIGIIILALGCVLFISSNYFWGYTGRLLQGLGSAIAFPASVFLAVKAFSGKNLATAIGVTQTLGMLGGSAGQKLSNSYLTSGNSYNSLWIIFGVSSLVLGVLAFVFTPKTNTDEFTEVRKQPLLANYKIVFSNWQSWLCGFASGLLFAPTTIFAMIWGVDFLEQARHLTHGQATVACALVPIGWAIGCPLFGWLADKFEKRIPVLAGGAVVMILCLLQLAFLPHLMGPGMSLFFMGVGSGAAMLPYSTIKEVNPDKVKGSATGAINFLVFGVTSLLSPVFTHLFASKLDMAVNKNAIFQQSCFFFIIAIGIAIFLCTFLRETGKEK
>NZ_CP050993.1|WP_168638826.1|2298167_2299019_+|hypothetical-protein
MKKAILMTVLISALSVSQTITAQMPTPTPNNISLEYQLEKEAAGIAVSDDHRVFIALPRGGENHQLPSVVEMVGQKMIAFPNEEINKNTNSDYNSHLVSILGITIYKNTLWILDQGKRAGVDGIPDGSTKVVAVDINSKKVIKNIPIPKPFFRETIQLNDLRFDPTHGKEGTIYISNNGFAKPDQSLIVMDVATGKLRELFKDIPEVSPAKGFISYVDHKEQGCVQYDLHQDQDRPEVFFFYERWESREILEQHLKTDHLNTWGDQQKELLAAPMEVFIMDKL
>NZ_CP050993.1|WP_168638825.1|2297306_2298149_+|NAD(P)-dependent-oxidoreductase
MSTEKLGFIGLGNMGHPMAKNLEKAGFPLFVYNRTEEKAEDFRSKSTVCQSVADLVNEADIIFTMLTNDQAVEAVYKDILKNDLSGKLFVDMSTISQKVSREVGDAVKIEEAHFIDAPVAGSTKPAAEGTLIIMVGGENDDVQRATPYLEKLGKIKHLGENGKGLAAKISINYFLAMIYEGLAETVLLSDKLGIDRKAMLEIINESASGSGATKVKTPLLLDDNFAPAFALDLMLKDIRLAKDAGADYPTGTSILKTYTEASEKGFGKDDVIGIINYLKK
>NZ_CP050993.1|WP_168638824.1|2296829_2297273_+|hypothetical-protein
MNLSYLAGVWYIVLSNFPMWTKGDKIKPNFNYNIETKNGIRGLSDEVKFLKNGKTKSIKGWDRPTDQENTKFIWRGSGLLSIAKSQWEILYRSEDFSWMVIHFEKTLFTPEGYDVVCKDPKDFLRNKDLIFKKLTELKITGLQEIPQ
>NZ_CP050993.1|WP_168638823.1|2295233_2295629_+|amidohydrolase-family-protein
MSLKNSPLFETNIKAFQTSLKNVKRVYDAGIPVAFGTDSGAMFLRAQGFSEHLELQLLVEAGLTPNQAITIATKNAAKAIGIDKDFGTLEVGKTADFLILDANPLNNIKNTEKINALYKAGKLVSKGPLAQ
>NZ_CP050993.1|WP_168638822.1|2294555_2295209_-|TraM-recognition-domain-containing-protein
MGNDSTLPQVYAPIISLIISVGMRQMNKPRQQKSVVLLDEAPTIYIPNIEQIPATARSNKIATIFGVQDFSQLVDNYGEDKAQIIISNLGNQFFGRVTNGRTAEMVGKLFSKEDRTYINKNTGTGTSGQLVHTQSNQSSGKSESIQERDRVKVSDLINLNTGEFYGIIAEGQPKEFFKTQFLTDFAESRENDKRAVTDMEMQENYYRIIEEAKRIVI
>NZ_CP050993.1|WP_168638821.1|2291886_2294559_+|TonB-dependent-receptor
MSGKMLSNYIKKISHLFFLLIFINSYSQITIKGSVFSNSEPIYHANIVLLDNQNQIETFVFSNQDGSFSLNTQFRGIGKIKVSAPGFVNVEKEIHIKTESIDISKINLKESVKEIEEVIIKNKNPITVKKDTIEYKAASFANGTENNLEDLLKKLPGIDIDKDGKIKIGQKSIEKVLIENDDLFEKGYQILTQNMPSAPIEKIQVISKYSKNKLLKNIENSEAMVLNITLKDKSSNRWMGSYHIASSSYIEKLRQLKVNLMNFSKKKKIYLLFNTNNIGINEMKGVEYFIKNSTENSVENIGNIENSTKIINLHVYNSLFEEKRTNFNNDYLGAFNYIKNYEGGYHLKIAGIYNKIGNENQINSVYNFDYNGLKFSNKEEKIWKLKQQNIVTKIELIKDFKNNSSINFYNKLSWINNNNDNNFIFNNDYNPQQGLNKIFSNENKLVFTKKIDSSTAIVGVGRFMLQDRPYLLTEKNNLVQKIFNHPTAEFLQQDIDSKYSYGGFKISYIKSLDKHNIELPIGAENQRDKLTSKIQLLDSSQNQVWINEDKIFSNNLEVVKTNFFINPTYQYKVEKWKVKLSGNTSFLNIKSYDKNTFKDFLFSPTFTVRYENKSTGNFALEYIKTFSNTEITDMYNGYIYLGNRIFAKSNTDFNLLPNYSINFDYQLGNVLKESMSFNINYLHNNDYISSNFIVNPDYTFNQKIILKNNYYLNVNLELKKYINLINSRFSLINKLSKSSYENSVNDSRIQKTKSTNYTLGFELKSGWLKSVNYELGYNWVFNYLTSANNKRDYINQNGYFNLYYNLSSKLFIDSNIEYYLFGQSNQKHTTFVDLKASYKLIDSKMNIFIQGRNLLNTKYISGYSINNVSESFYTQKLLPLSILIGFNKNF
>NZ_CP050993.1|WP_168638820.1|2291153_2291909_+|GLPGLI-family-protein
MKKQLCLILLFCLVLLKAQDNFILYNKITDDTGQTKASQNYLLSYKNNSSIFCFYKDDIAKDLKSFLSENIPLRGSEIIRNTGKNFEIRSTGFTKEPLYTIDNYQDFNWVISKKDVKDIMGYKCFKATGKFRGRTYIAWFTPDLPNDIGPWKFRGLPGIILSISDTDNIFTFQAIEIHLNAINKFPISERVNFDKNQNYISYKDFINKENSHINDMRKRIEANRSTGTVVLSRSNNRDFKIEKSFEWENAK
>NZ_CP050993.1|WP_168638829.1|2306609_2307728_-|DUF3320-domain-containing-protein
MHLFATLQTDQIDLSRTSAEGVAGLKAFLHFAEKGHLSIRPEDIQETRNKQHLSETISKRLKEKGVEVKCNIGTSGFKVDIGIVHPDKPEQYILGIVVDGHYYYNARTTNDREMVMPSVLKALGWNIHRVWTIDWYENSEKIVDTIIEKVKQLQTRSEDYEEKITEPVVLPEFEPIKAMPDAPINTVSMQKPYIAHILIPVPNANSETIYEFQNRNIIRQQIQSLVDTEAPVSKGLLYRKVLQIWNTSRVGAKLDRYLEGIIKEMNLVQTVHHQPFYWSNGTALNYYRINDTEKRNMEDIAPEEILVALQEVITDNLSIEEDELLRYLARTFGFAKLGKQIDAILRYTVDLAEKENIVKKENGRIILTIPKE
>NZ_CP050993.1|WP_168638830.1|2307685_2308063_-|hypothetical-protein
MEFIKSHYNNSQKRKLSLGVVTFSQTQQNLIEDKLQKLFMSDPRLEEFAHESDEPLFVKNLENVQGDERDIILFSICYAPDEEGKMSMNFGPLNRNGGWRRLNVAVTRAVMKCIFLLHCRRIRSI
>NZ_CP050993.1|WP_168638831.1|2308014_2312418_-|DUF4011-domain-containing-protein
MEQNATLIIHKQTLPFLNISLYLNGIKPVQSLILENTSEKDTSPLEVNITADLPCVEPFRYTVPFIPAQKGIKIPLENLKFNRDFINRLSETEKANITIGITGENAITINEIFELDIHPLEYFGGFQILPELIAAYVTPNHPYIYHLKRKAVEILEKQNLKTAFEGYQANDPERVLQMMSAIYSAVQNEGIVYSALPPGYEATGQRLRLLNTIQQEKFGNCIDLSLLFAACLEAIDLNPILILVKGHAFVGCWLQDDKFSEVINDDKTAITKRLSKGIREMAAFEATSICKGNNLKFSDALNAGEAQLVQQEDFLLSVDIKRARTLRIRPLPLLTNVSEIQLDEEIIRQTETAEMENHFELGTIYQDDLLQGNKPKTKQKIWERKLLDLSLRNNLLNLRMTRNMLQLVDIDISNLEDTLSEGKSFSVIPNPNAEVLRKYNLFTQPLHSSSPLYQLANDELKYNRLLTHYHQQDLDSILTYIHKNAKQAIEESGSSTLYLAVGLLKWFDRKTPDQPRYSPVLLLPVEISRRSVNSKFILKSREEETMINITLIEFLRQEYELNLSALEQLPYDEKGVDVAKVMGILRRAVMQLKGWDVEEQLVLGNFSFSKLILWKDIVAHQEDLLKSDMVRSLVEGKLSFSENYETISASDFDNIHSQSLALPIPTDVSQMEAVLTAQQGHSFILHGPPGTGKSQTITNIIADALYHGKRVLFVAAKKAALDVVQRRLEQIGLAPFTLELHSNKSKKSDVLEQLAKSIETAKLVRTADFEQEAQRLDAAKKAISDYVNILHQKQQVGWSLYDSITALENDHDENFPKNFIPEEVLQQLDAALWQQWTDWIPQFQSVVKFIIHPSENPLSAFNLPHYSPVVNDEIAKQTQQLLQLLPDVQSKLKSLASAIHFPFSVQTKTEWGQFIQVIDSLQNLPDIPLELILYLSDKENYQMYEEWKSAFQQYQNSLNNILKNYKRNVLNTDISATEVQWKKAQQSWFLPKWLKSGKIKKELTAFRNAAFTNDHEVEQLFSDNNQLQEAQRLLQQRRFAELQKALKNLYKDEQTDLGDIDKKATFTQHLSNITNIWGRNALGQWIQILQQENMQYSDEIKQKHSTLIDEFLQLTAIFNEQEKNYGTLTGTNFQQKENWLERTVAQLQDIQENLPQLKNWMNYVQLRNQGEDLHLKWLINAYENKVCNAENISDYFYYAVHASVVQHVISQHESLSLFNAGLFESKVEQYKKIAKEFQALTIQELRVKLAAQLPNTTAEAMQSSEIGILQRAIKNRGRGLSIRKLFDQIPALLPRIAPCMLMSPISAAQYFDVDASHFDMVIFDEASQLPTCEAVSALARAKQAVIVGDPKQMPPTSFFSSVKLDEENMDVEDLESILDDCLSLSVPSKYLLRHYRSKHESLIAFSNVNYYENKLLTFPSADDLNRKVKFHHIEGFYDKGKTRTNKFEADALWNSSNLITIIHRNGN
>NZ_CP050993.1|WP_168638832.1|2312481_2312820_-|CRISPR-associated-endonuclease-Cas2
MNAERFNAYRIMWVLVLYDLPTETKANMKDANRFRKALLDDGFTLFQFSMYVRHCPSRENAEVHIKRVKFMLPKAGKVAIMCITDKQFGDIEIFFARNKEEPPPTFQQLELF
>NZ_CP050993.1|WP_168638833.1|2312862_2313765_-|type-II-CRISPR-associated-endonuclease-Cas1
MITRSIYIGNPAYLKLKDGQMYILCPETKQAKGKVPVEDLGLLMLDHFQITLSHQLIQKMMGNNVVVVSCDDHHLPHGIMLPLYGHTEHSDRVKDQLEASEPLKKQLWKQTIECKIENQKEVLRRLGNYYEPMLDYQNNVKSGDSTNMEGIAAQHYWKYLISLDFLRQRLGDSPNQFFNFGYAVLRSIVARAIVETGLLPVLGIFHKNKYNPYCLADDLMEPYRPFIDLLVMQWLKINPDTEELNKEFKAHILQIATKDVMIDDKTRPLLVAVKTTATSLYKCYTGEKRLISYPELIGIG
>NZ_CP050993.1|WP_168638834.1|2313772_2314219_-|PIN-domain-containing-protein
MISEKFSSDKDNDFKKIKYSIDTNILVYAYEKSNHAISETAINLINQEANISNYAYQEFLFNLKEKGLLKGEISKMGIELLNILNLNRIDKDTYRYAHYLMIKHNFQLGDSIVIADAILNNCNVLYSQDDMGHHGLVDKKLRIINPFK
>NZ_CP050993.1|WP_168638835.1|2314190_2318480_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MTKNILGLDLGTNSIGWALIQQDFQNKQGEILGMGSRIIPMSQDVLGDFGKGNSVSQTASRTGYRGVRRLRERFLLRRERLHRVLNILNFLPEYYASQIDFEKRFGKFREETEPKLAYSKEGFIFKNSFEEMLTDFKNHQPQILQNDKKVPYDWTIYYLRKKALSQKIEKEELAWILLNFNQKRGYYQLRGEDFEEEKDKMFVRLKVDRIVDSGENVKGKILYDVYFDNGWKYDKQIVKTEDWIERVKEFIVTESFLKNGDIKRTFKAVDSEKDWIAIKTKIEQEIDNSDKTVGTYIYETLLQNPKQKIKGKLVRTIERKFYKEELKQILETQKEFHPELNNESLYNDCVRELYRNNEAHQLTLSKKDFVHLFMDDIIFYQRPLRSQKSSISNCSLEFRKYKDENGVEHTQYLKAIPKSNPYYQEFRIWQWIYNLNIYKKEDDANVTKEFLNTTKDYENLFEFLNNRKEVDQKALLKHFKLNDKTHRWNFVEDKKYPCNETKTMIYERLKKVENISNDFLTREIEQKIWHIIYSVNDKIEYEKALKSFARKNHLDENSFFEAFKKFPPFKNEYGSFSEKAIKKLLPLMRLGKYWNYADIDKYSRERIQKIITGEYDENIKDKVREKAVHLTTENDFQGLQLWLAQYIVYGRHSEASMIGKWNSADDLEEFLKEFKQHSLRNPIVEQVITETLRVVKDIWMKYGNGAKDFFDEIHIELGREMKLPAEERDRLTRQISENENTNLRIKALLAEMMNDGAVENVRPYSPMQQEILKIYEDGVLNSGIEIEDEYLKISKTAQPSSSDLKRYKLWLEQKYKSPYTGQIIPLNKLFTPEYEIEHIIPQSRYFDDSFSNKIICESAVNKLKDNYIGFGFIKQFGGTIVECGFGKSVKVFESEEYEDFIKKHYANNRSKRNKLLLEDIPEKMIERQMNDTRHISKYISGILSNIVRVEDGTDEGVNSKNIVPGNGKITTQLKQDWGLNDVWNDLILPRFERMNQLTNSNDFTAWNENHQKFLPTVPIEYSKGFSKKRIDHRHHAMDALVIACATKDHVNLLNNQSAKSDTKRYDLKKKLMKFEKVVYNHPQTGDRIEREVPKQFFKPWDNFTVGAKNSLEKIIVSFKQNLRVINKATNHYEKYVEKDGVKTKERVEQTGTNWAIRKPMHKETVSGKVDLPWVKVPKGKILTATRKSLDTSFDLKTINSITDTGIQKILKNYLEFKGSPELAFSPEGIEDMNKNIEKYNDGKPHQPINKVRIFELGSKFPLGQSGNKKDKYVEAAKGTNLFFAVYEGKNEKRSYETIPLNIVVERQKQGLLACPETNEKGERLLFYLSPNDLVYLATEEENDIAPSINFNNINKEQINNLYKIVSFTGNRLYAIPLSVATTIVNKVEYTQLNKIEFTKEKEFLLKLNVNRLGDVKTFTANDIRKIFIG
>NZ_CP050993.1|WP_168638836.1|2318882_2319086_-|hypothetical-protein
MAPKLTRLCIYPKDIQLITGRSERHCREIMYIIRRSLNKQDHQFITIDEFCTWAGLDPAAVRQILHN
>NZ_CP050993.1|WP_168639710.1|2319409_2319922_-|hypothetical-protein
MDDELDYLHYFFSDQREFVAYYKRGATYLDDKYFLRRRYDLYTPLETDLHSFDSRFATSHDHVAARILAFEEYEAFLRQWLAKHSKNRQEEDSFAGMVTWSASKAALTELLFSLHLTGCFNGGNIELAEVIRWAEASLHTDLGNYHKTLAEVRNRKTRRTKFLDLILRNF
>NZ_CP050993.1|WP_168637941.1|2320571_2321918_+|IS5-family-transposase
MLGKNPEKKPELFRPMLVDFINHEHELVLLSEKIDWNYFEKEFSPLYSKVGNPSHPIRFMVGCLLLKHLYNLGDETLEKAWIMNPYMQYFCGRVFFEHEFPCDPSNFVHFRKRIGEKGIEKIFAYSVRMHDAKTNTSNFVLSDTTVQENNTSFPTDAKLCKKVIDYCNKIAGNEGIKQRQRYTKVSKQMVRNTYNGKHPKRAKAARKSQRQLKTIAMRLIRELQRNFNAEQQEFYKDLMTLYTKVVTQKRNDADKIYSIHKPFTRCIAKGKAHSQYEFGNKVGLITTANKGKKIILGIKAFLQTPYDGHTIEPLLEQMETGGQKLPKELLYDRGGRGKSEIKGVKISIPSTPRKKDTAYQKQTKRKKFRTRAAIEPIIGHLKTDFRLAKNYFMGETGPQINALLAATAWNMKKMMELLKQKIIFLFYKIQIMLFSNPVFKNKLNSGFC

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Crispr_ID: NZ_CP050993_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050993_8

3295411-3295500

Orphan

Consensus_repeat	Method
GCTTCGACTCCGCTCAGCATGACAGTGTGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050993_8

>merge|NZ_CP050993|8|3295411-3295500|CRISPRCasFinder
GCTTCGACTCCGCTCAGCATGACAGTGTGGGGTTGGGAGTTGGAAGAAGGGGCAGAGATGCTTCGACTCCGCTCAGCATGACAGTGTGGG

>NZ_CP050993|8|8|3295411-3295500|CRISPRCasFinder
GCTTCGACTCCGCTCAGCATGACAGTGTGGG	GTTGGGAGTTGGAAGAAGGGGCAGAGAT
GCTTCGACTCCGCTCAGCATGACAGTGTGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050993.1\|WP_168639465.1\|3302326_3304081_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP050993.1\|WP_168639454.1\|3291751_3292780_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|132997
NZ_CP050993.1\|WP_076782251.1\|3297447_3297681_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|284291
NZ_CP050993.1\|WP_168639451.1\|3288311_3289418_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340847
NZ_CP050993.1\|WP_168639461.1\|3299058_3299628_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168639457.1\|3294644_3295124_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168639453.1\|3290513_3291686_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340847
NZ_CP050993.1\|WP_168639466.1\|3304351_3304600_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168639463.1\|3300971_3301250_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168639450.1\|3287196_3288243_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227372
NZ_CP050993.1\|WP_168639462.1\|3300097_3300301_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168639452.1\|3289417_3290509_+\|EpsG-family-protein	unknown	unknown	gnl\|CDD\|379716
NZ_CP050993.1\|WP_168639460.1\|3298330_3298534_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168639458.1\|3296286_3297045_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168639449.1\|3286197_3287196_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|366154
NZ_CP050993.1\|WP_168639448.1\|3285207_3286197_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|182223
NZ_CP050993.1\|WP_168639459.1\|3297046_3297451_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050993.1\|WP_168639455.1\|3292781_3293660_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|132997
NZ_CP050993.1\|WP_168639456.1\|3293656_3294634_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|366154
NZ_CP050993.1\|WP_168639464.1\|3301442_3302294_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378161

Protein	Function_ID	Function_description	E-value
NZ_CP050993.1\|WP_168639465.1\|3302326_3304081_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	0.000322956
NZ_CP050993.1\|WP_168639454.1\|3291751_3292780_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|132997	cd00761, Glyco_tranf_GTA_type, Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold. Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.	4.95132e-31
NZ_CP050993.1\|WP_076782251.1\|3297447_3297681_+\|hypothetical-protein	gnl\|CDD\|284291	pfam06826, Asp-Al_Ex, Predicted Permease Membrane Region. This family represents five transmembrane helices that are normally found flanking (five either side) a pair of pfam02080 domains. This suggests that the paired regions form a ten helical structure, probably forming the pore, whereas the pfam02080) binds a ligand for export or regulation of the pore. Tetragenococcus halophilus aspT is described as a aspartate-alanine antiporter. In conjunction with aspD it forms a 'proton motive metabolic cycle catalyzed by an aspartate-alanine exchange'. The general conservation of domain architecture in this family suggests that they are functional orthologues.	0.0045042
NZ_CP050993.1\|WP_168639451.1\|3288311_3289418_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340847	cd03820, GT4_AmsD-like, amylovoran biosynthesis glycosyltransferase AmsD and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.	1.65599e-88
NZ_CP050993.1\|WP_168639453.1\|3290513_3291686_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340847	cd03820, GT4_AmsD-like, amylovoran biosynthesis glycosyltransferase AmsD and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.	2.02476e-103
NZ_CP050993.1\|WP_168639450.1\|3287196_3288243_+\|hypothetical-protein	gnl\|CDD\|227372	COG5039, COG5039, Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	1.64735e-55
NZ_CP050993.1\|WP_168639452.1\|3289417_3290509_+\|EpsG-family-protein	gnl\|CDD\|379716	pfam14897, EpsG, EpsG family. This family of proteins are related to the EpsG protein from B. subtilis. These proteins are likely glycosyl transferases belonging to the membrane protein GT-C clan.	8.08883e-08
NZ_CP050993.1\|WP_168639449.1\|3286197_3287196_+\|glycosyltransferase	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	1.28235e-35
NZ_CP050993.1\|WP_168639448.1\|3285207_3286197_+\|glycosyltransferase	gnl\|CDD\|182223	PRK10073, PRK10073, putative glycosyl transferase; Provisional.	7.06247e-31
NZ_CP050993.1\|WP_168639455.1\|3292781_3293660_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|132997	cd00761, Glyco_tranf_GTA_type, Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold. Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.	7.23526e-30
NZ_CP050993.1\|WP_168639456.1\|3293656_3294634_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	8.9415e-35
NZ_CP050993.1\|WP_168639464.1\|3301442_3302294_-\|hypothetical-protein	gnl\|CDD\|378161	pfam09357, RteC, RteC protein. Human colonic Bacteroides species harbor a family of large conjugative transposons, called tetracycline resistance (Tcr) elements. Activities of these elements are enhanced by pregrowth of bacteria in medium containing tetracycline, indicating that at least some Tcr element genes are regulated by tetracycline. An insertional disruption in the rteC gene abolished self-transfer of the Tcr element to Bacteroides recipients, indicating that the gene was essential for self-transfer.	5.22781e-66

>NZ_CP050993.1|WP_168639457.1|3294644_3295124_-|hypothetical-protein
MTTDYTWKQNAWTGNYTLYRSNQPVGYLKKRNFFSAMMEAFTGSMTYTIGPAKWWLQQPLIIDQQDNKIGYIRYNKWGNRATVNLHGKAYRWQYSNGLNTRWEIKNADGTAIGSSTGTPDEGALLAAGLYIHSRLRHRTTAIVILVLYVPMLLRFFMNR
>NZ_CP050993.1|WP_168639456.1|3293656_3294634_+|glycosyltransferase-family-2-protein
MSHPYFSIIIPVYNVEDYLPKCLESVLVQSFQHFEIILVDDGSPDHSGKICDENSEKDLRITVIHQSNGGLSDARNEGLAAAMGEYIIFLDSDDYWDDPAALGQLHQSLTERPSDILLFNCKDFDCIQNQMFKNRSDYDLRVFSESKDDILRYLVQSNLFPGAAWILSVKKSLLKQNNIEFVKGHKAEDVDWLLRIFYHAEKINAINADFYVYLKNRNGSITSNVDDKGVNGIFYAIEQWKTRFIKSGNPMISVLQYQYLILVMNLYKAGMLNHYETLLKAHRDLLDKRFSASKNNKIASLVVKIFGFRLGAKFLSLLYQFKKRV
>NZ_CP050993.1|WP_168639455.1|3292781_3293660_+|glycosyltransferase-family-2-protein
MSRLTIFTPAYNRADLLPRLYDALKRQTNSFFEWIVVDDGSTDDTLALLEGWKTENIIPIRYYHKENGGIHTAYNVGIEKADTELWMCIDSDDFPPDDAVEKILQLWDQKGSEKYAGIVGLDYGMDGHPLKNLTLPDVEALRIMDLTTTYQFRADTKMVHRAELLKAVAPMQVFAGEKNFNPIYLFLKIDQLYPLLVLNENLCFVDYQETGMANNIMKQYVNSPQSFAELRRMMMGLSHAPYSFVFRNAVHHVSSSLFARQNFLKDSPKKLTSILAFPFGVLLYFYIRKKQS
>NZ_CP050993.1|WP_168639454.1|3291751_3292780_+|glycosyltransferase-family-2-protein
MNEIKISVIIPCYNVQNYVGQCLQSIVSQNYRHLEIICINDGSTDDTLSVLNSYAVNDSRIIIVDQDNKGLSETRNKGISIATGEYLMFVDGDDWVGVGYFDTFVSPLKEDVDLVIGSYTREFATKSLSRDLKIEGKYAADFFQRRLIGLVDEELRDPSQADSIVTIWSKLYKFEIIKDHAITFDPIEKIGTAEDLLFNLKYSKYCDKIFVIDQPLYHYRKTDNSFTNNYKSHLFNQWKNLFECIQTYCDSAQKMKAYHNRVALSIIGLGLTEIRNPAGSQVIKNNLNNFLSDQLYRDAFSKFDTHYLPLHWKLFFFLAKNRFSGFLYQLLLIMNKLINKNN
>NZ_CP050993.1|WP_168639453.1|3290513_3291686_+|glycosyltransferase-family-4-protein
MNIVYCINSINYAGGTERVTVTKANELSNIGGNKVFLVVTDDNGDYPFLLDRKVKVINLSVNYYLDDWHTGIKAKFSQFRKKLKHRKMLRMMLESLSPDIVISTGQSEKLFLSRNFLKKRDVVFIREFHFSTNYRLLFAKSTFDFILAKIKNFIDFKFISKRFDAIICLTPKDISENWEGYKNVYFIPNPLTIPIKKTSKIRHEYKRIITVGRLTAIKNYSSLIRSYALIAHKYLDWTLEIYGDGDQREKLNAEINGFGLSNQIILKGYSSDIASKLANADIFVMTSLTEGFPLVLFEAMSNNLPVVSYDCPYGPSYIIDENINGFLVELNNEVGLADKIELLINNEELRIKMGINGFDKTLNYLPELIALKWMAFFTELQKKHQIHKKM
>NZ_CP050993.1|WP_168639452.1|3289417_3290509_+|EpsG-family-protein
MFDWIPIASYTSLYHQVLLVTGLLVLLHGYVYDIHNASSLLFFKILGGLLLCWLILYIGQRPINGGFGDTGTYARSYNLFARSAEVSIDGDYMFNYLQKFCSKIMNVQSFFTLVAFIYVMPCYLFSRKYFGRYWFFAFYMFIGSFSFWAYGVNGIRNGMATSVFILALVFYNQKILCYALMYLAYGFHNSMAIPLAAFLFADLYKNPRWYLYIWLAAIPLSLVAGSMFQALLGSLFSDNERSVGYLTKGNVNNDTFSSTGFRWDFVLYSGSAVFAGWYYIFKKKITDQFYIHLYGTFIIANAFWILVIKANFSNRFAYLSWFLMAPVVIYPLTKYKLAEDQYKVLGLVVMAYYFFTYFMFIKS
>NZ_CP050993.1|WP_168639451.1|3288311_3289418_+|glycosyltransferase-family-4-protein
MTRLLYITNGVNGVGGLERVLSVKTKLFIEKKRYEIHIAGLKGTDSNFFYEFDPSIVFHSMQISGNPIVYMYRYISEIHRLIKKVQPDIVIVCDDGLKAFITPFIRGKKIPIVYERHVSNHIFFNDNQSFLEKLMVNIKVGIMNYLSTYFSVFVVLNEGNKEEWSNKGNIRVIENILSFSPKTVSSLENKKVIAVGKQSYQKNYERMIDIWKDIAADYPDWQLHIYGKKNDNINLEEKIISHHLENKVVLCDPDKNIMERYLESSIFLMTSRYEGQPMVLLEAMACGLPSVCFDFDHGPREIIGNGKDGFVVPYKDDKEFTDCLKSLLGSLALRKQLGRNAKISSEKFSRESVFMKWDHLFKSLMRKS
>NZ_CP050993.1|WP_168639450.1|3287196_3288243_+|hypothetical-protein
MARKYLGFRFKYRILLLLQYFKPANYFKQVKPDHTRNQAYVFLAADYGNLGDVAITYAQKKFLEEYSHFQVIEVPISKSLEGLWFVKKNIKKGDVVTTVGGGNMGDLYDQIEYIRQLTIQFFPHNRIISFPQTFDFAETKSGRRYLKKAQDVYQRHKDLHLIAREQTSFELMNTYFPSAHILKTPDIVLSLDERNSSVNRKGVVICMRQDDEKSLTKEQTEFVIKIAKTRFTNVRFYDTHIGKDHLSEDDRTRELHKIWDIFKSAELVITDRLHGMIFCHITGTPVLVFQNNNHKVRETYDWIKENKSITLMKEFQEKDVSAFIEEYTVLESFSLDLQKKYLPLIQII
>NZ_CP050993.1|WP_168639449.1|3286197_3287196_+|glycosyltransferase
MPIFSVILPCYNVERFLPRAIESVLSQSYTDFELLVVIDGSPDNSCQIVESYAQKDHRIKVFEKENGGLSDARNYGLERATGQFIYFMDSDDWIEPDLLAENLKIIETENIDLVIFGYIQDDEDEQGNVLQSTSVAPQISRLTKGNENIALDEHHLGLMGYAWNKIYRKSFIDQYHLRFEKGISLVEDVLFNALIYRSSNVIRFNPKTYYHYINRPVVTLMKTFHYGSFELQKKKLTAIKLFLEEWNVQNQKEVLSFIQVQGIRYCIHNLFSYQNQLSTSEKLNFIRLMYNDADTVKLIEDYNPDFLNGKIYKFLIKYKGIRATYIMAKILK
>NZ_CP050993.1|WP_168639448.1|3285207_3286197_+|glycosyltransferase
MNISVVIPVYNTELYLERCLNSLIAAQVEGLENEIILINDGSTDQSLDICNTFVEKYSNISVFTQINQGLSSARNFGISKANGLFISFVDSDDTVDLNYFSALKPFLISKNSVINFGYNRVQNNVKKSEHPFWNQEIITKEILDIAIVNSSKNNMLWLVWRRVYNREFLQNYNIKFAQELKYGEDSVFSLEVFKNVNEIINIDHCLYNYYDNENSLTTTRIKVDLLQKFELQYKKRIEVEREISVKRGIDLSKIHKNIADNYLNHALFILIINIKNSKCDKTLKLNNVRNSIIYKELFPYYKYDVNRIKRSIIIKLFQLRLFSLIFKLL
>NZ_CP050993.1|WP_168639458.1|3296286_3297045_+|hypothetical-protein
MARQKSIIKLHGTLGDITFYRSKDGYMARERGGISASRINSDPKFQRTRENMAEFGRAGKAGKLLRNSIQSLLRTSADPRMVSRLTQQFVKVIQEDAVNPRGLRNVIDGEAELLQGFEFNNQSQLSTTIVAPMTYSIDRATGQATVALEAYVPTDSIIAPTGSTHYQLVSAAMDIDFEAVSYTTDHAETAILPLDPVSTTASQLSNSLPAGSARPMFLIFGVNFYQEVNSQFYELKNGSYNALQIVKVSGTP
>NZ_CP050993.1|WP_168639459.1|3297046_3297451_+|hypothetical-protein
MEVLLIRRYAPQGTNGELLIHGARVCYTIELPWRQNARRISCIPEGCYALRLRYSARYGEHLEVTGVPGRSAILIHAANDALKELQGCIAPVTELTGAGKGQASRLALERLKAHVCPLLKQGTPVCLTIKTPSS
>NZ_CP050993.1|WP_076782251.1|3297447_3297681_+|hypothetical-protein
MKSTPLMRRLQSPTPRFFKRLRNYGLLLTAISAVLTTAPIALPAILIKIAGYAAVAGGIASAVCQATTADSQPGDER
>NZ_CP050993.1|WP_168639460.1|3298330_3298534_+|hypothetical-protein
MRVQGSGFWMMGVGSWKKGWEESRGKKKETRKKKQEKREKKQEKRIKMNGGGRWKLDDGGFDSRFRV
>NZ_CP050993.1|WP_168639461.1|3299058_3299628_-|hypothetical-protein
MTIHKILLIGAILLSAVIQSQETKKLKKPTDTPYLKTDTIPKVVKEQPWELNKPILILDNHPVPYETILTLQSDKIESVKIEKQANQAESVDKKSTLIINMKPVPKTILIPVTALISKYTEIKDGKYIVSIDGEPVNLQQDQLLVDEKNIMQIRITKLDQLGLAPNLYQVRLLTRNNKNLQKANTIIIR
>NZ_CP050993.1|WP_168639462.1|3300097_3300301_-|hypothetical-protein
MKQGITRLCIYPKDIQLITGRSERHCREIMYIIRRSLNKQDHQFITIDEFCTWAGLDPAAVRQILPN
>NZ_CP050993.1|WP_168639463.1|3300971_3301250_+|hypothetical-protein
MGGGSWMLDVGKNQEKREKKKEERGKMKGEGCVGGFEGSRFRVQSSGFLGMDVGSWMMGEGCFESLSMTVGRFKVQGSRFRVQSWEVRVRMR
>NZ_CP050993.1|WP_168639464.1|3301442_3302294_-|hypothetical-protein
MNSNDLIAKVGRLWLDLDHKLKDHNTHKKPDLPQAQLALMETDEAIRTLKSWVITHQFDSWQKEIHFFKYLKPKFVAKFIFLSKVVAFYSGLPYGGDRLVKKKIETEFETMRIFSEDNSEFINYYRRQSTYLDKKYFLRFQYDLYVRLSLDLHSFDDRFSTAQDYLVAHILSNDDYEGFLKKHWQQVKKAQEWPDTPAAHALQWTGSKAALTELVFALALSGSFNHGNTDLAEMVRHIEKAFATDLGNYHKTFSEIRARKSSPVKFLTHLSDILRNHIDNTDD
>NZ_CP050993.1|WP_168639465.1|3302326_3304081_-|helix-turn-helix-transcriptional-regulator
MVRHFLICFCILFLAQDVSGSNTLPDYDSWQARYAHLKKNDPAALPWIRRSIATAKITGNARHLMLAYEDAIFYNAQRDIKQRYADSTIQAAQRLDSPDDLAKAFLGKGIIWYFNYRDFPKALQEYTTAYALITDSGNQYLRHKVAYHMGVVKNHLGLYDEALPLFTGAADYFNSHRNNPSDPNAAYNNTRGYLNTLHQLAIIYRSTGKALELQNILEIWEPLVKGSDAFSQERAYFLKEKGIQHYNQRAWHSAALMLQQAAAMLQNADDAASLGSVWYYQGRVAQAMHGTATAKAYFLKTDSLYTRLHLVTCEIRAGYEGLLAIPSLPRADILCYTHRLLEIDSIFKKDYPALVSRITAKYDQLNLIRENSQLEKDRLAGKQRTRYAVGLAILVIILLSFLFCRERLLSKRFSRCWNAYRHKEEQTGLQKQSKNSADERFSETIINEALAKLEKFEEKELFKKKDLTFSKMSDITDIRRQLLTYILKTKKVSYYRYLHGLRIRYMTRLMLQDRRYLAYTLDTLADLCGYQSRQVFAKQFREINGITAQEFIKRELARVNEQGHSAPVAEDGSRPPEIAQSKEL
>NZ_CP050993.1|WP_168639466.1|3304351_3304600_+|hypothetical-protein
MKTSISLICILLLGTMISCRMEEDGSYIPNTAVPLNGIAGKASSPANSPSPPHGTVKRDGDDAEDKDKTRKDNQDWKHEPGQ

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP050993_7	7.1\|2305697\|25\|NZ_CP050993\|PILER-CR	2305697-2305721	25	NZ_CP050993.1	588375-588399	0	1.0
NZ_CP050993_7	7.3\|2305697\|30\|NZ_CP050993\|CRISPRCasFinder	2305697-2305726	30	NZ_CP050993.1	588370-588399	0	1.0
NZ_CP050993_8	8.1\|3295442\|28\|NZ_CP050993\|CRISPRCasFinder	3295442-3295469	28	NZ_CP050993.1	3295897-3295924	0	1.0
NZ_CP050993_7	7.5\|2305851\|30\|NZ_CP050993\|CRISPRCasFinder	2305851-2305880	30	NZ_CP050993.1	584243-584272	2	0.933
NZ_CP050993_8	8.1\|3295442\|28\|NZ_CP050993\|CRISPRCasFinder	3295442-3295469	28	NZ_CP050993.1	3298796-3298823	2	0.929

1. spacer 7.1|2305697|25|NZ_CP050993|PILER-CR matches to position: 588375-588399, mismatch: 0, identity: 1.0

taataacaaaaaggtataatgtacc	CRISPR spacer
taataacaaaaaggtataatgtacc	Protospacer
*************************

2. spacer 7.3|2305697|30|NZ_CP050993|CRISPRCasFinder matches to position: 588370-588399, mismatch: 0, identity: 1.0

taataacaaaaaggtataatgtaccttttt	CRISPR spacer
taataacaaaaaggtataatgtaccttttt	Protospacer
******************************

3. spacer 8.1|3295442|28|NZ_CP050993|CRISPRCasFinder matches to position: 3295897-3295924, mismatch: 0, identity: 1.0

gttgggagttggaagaaggggcagagat	CRISPR spacer
gttgggagttggaagaaggggcagagat	Protospacer
****************************

4. spacer 7.5|2305851|30|NZ_CP050993|CRISPRCasFinder matches to position: 584243-584272, mismatch: 2, identity: 0.933

aatatcgccgtaaaggcaaattaattggct	CRISPR spacer
aatatcaccgtaaaggcatattaattggct	Protospacer
******.*********** ***********

5. spacer 8.1|3295442|28|NZ_CP050993|CRISPRCasFinder matches to position: 3298796-3298823, mismatch: 2, identity: 0.929

gttgggagttggaagaaggggcagagat	CRISPR spacer
gttgggagttagaagaagggccagagat	Protospacer
**********.********* *******

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP050993_7	7.1\|2305697\|25\|NZ_CP050993\|PILER-CR	2305697-2305721	25	MN032614	Aeromonas phage PS1, complete genome	171294-171318	4	0.84
NZ_CP050993_7	7.2\|2305774\|29\|NZ_CP050993\|PILER-CR	2305774-2305802	29	JQ768459	Pseudomonas phage Lu11, complete genome	256067-256095	4	0.862
NZ_CP050993_7	7.4\|2305774\|30\|NZ_CP050993\|CRISPRCasFinder	2305774-2305803	30	JQ768459	Pseudomonas phage Lu11, complete genome	256066-256095	5	0.833
NZ_CP050993_8	8.1\|3295442\|28\|NZ_CP050993\|CRISPRCasFinder	3295442-3295469	28	LQ581860	Sequence 19 from Patent WO2016102829	763-790	5	0.821
NZ_CP050993_8	8.1\|3295442\|28\|NZ_CP050993\|CRISPRCasFinder	3295442-3295469	28	LQ581858	Sequence 17 from Patent WO2016102829	763-790	5	0.821
NZ_CP050993_3	3.1\|1627814\|26\|NZ_CP050993\|CRISPRCasFinder	1627814-1627839	26	NZ_CP049159	Caballeronia sp. SBC1 plasmid pSBC1_3, complete sequence	590668-590693	6	0.769
NZ_CP050993_3	3.1\|1627814\|26\|NZ_CP050993\|CRISPRCasFinder	1627814-1627839	26	NZ_CP049320	Caballeronia sp. SBC2 plasmid pSBC2-4, complete sequence	142822-142847	6	0.769
NZ_CP050993_7	7.2\|2305774\|29\|NZ_CP050993\|PILER-CR	2305774-2305802	29	NZ_AP014659	Bradyrhizobium diazoefficiens strain NK6 plasmid pNK6a, complete sequence	13952-13980	6	0.793
NZ_CP050993_7	7.2\|2305774\|29\|NZ_CP050993\|PILER-CR	2305774-2305802	29	NZ_CP027149	Klebsiella pneumoniae strain AR_0363 plasmid unnamed8	12148-12176	6	0.793
NZ_CP050993_7	7.2\|2305774\|29\|NZ_CP050993\|PILER-CR	2305774-2305802	29	NZ_CP049701	Bradyrhizobium sp. 1S5 strain 323S2 plasmid pB323S2b, complete sequence	73330-73358	6	0.793
NZ_CP050993_7	7.5\|2305851\|30\|NZ_CP050993\|CRISPRCasFinder	2305851-2305880	30	NZ_LR134403	Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence	270731-270760	6	0.8
NZ_CP050993_7	7.7\|2306005\|30\|NZ_CP050993\|CRISPRCasFinder,PILER-CR	2306005-2306034	30	NC_042010	Streptomyces phage Paradiddles, complete genome	15487-15516	6	0.8
NZ_CP050993_7	7.11\|2306313\|30\|NZ_CP050993\|CRISPRCasFinder,PILER-CR	2306313-2306342	30	MN693439	Marine virus AFVG_25M521, complete genome	22340-22369	6	0.8
NZ_CP050993_7	7.11\|2306313\|30\|NZ_CP050993\|CRISPRCasFinder,PILER-CR	2306313-2306342	30	MN693531	Marine virus AFVG_25M28, complete genome	21633-21662	6	0.8
NZ_CP050993_6	6.4\|2300982\|35\|NZ_CP050993\|CRT	2300982-2301016	35	NZ_CP013709	Clostridium botulinum strain F634 plasmid pRSJ2_2, complete sequence	88549-88583	7	0.8
NZ_CP050993_6	6.4\|2300982\|35\|NZ_CP050993\|CRT	2300982-2301016	35	NZ_CP013844	Clostridium botulinum strain A634 plasmid pRSJ19_2, complete sequence	133986-134020	7	0.8
NZ_CP050993_7	7.4\|2305774\|30\|NZ_CP050993\|CRISPRCasFinder	2305774-2305803	30	NZ_AP014659	Bradyrhizobium diazoefficiens strain NK6 plasmid pNK6a, complete sequence	13952-13981	7	0.767
NZ_CP050993_7	7.4\|2305774\|30\|NZ_CP050993\|CRISPRCasFinder	2305774-2305803	30	NZ_CP027149	Klebsiella pneumoniae strain AR_0363 plasmid unnamed8	12148-12177	7	0.767
NZ_CP050993_7	7.4\|2305774\|30\|NZ_CP050993\|CRISPRCasFinder	2305774-2305803	30	NZ_CP049701	Bradyrhizobium sp. 1S5 strain 323S2 plasmid pB323S2b, complete sequence	73330-73359	7	0.767
NZ_CP050993_7	7.10\|2306236\|30\|NZ_CP050993\|CRISPRCasFinder,PILER-CR	2306236-2306265	30	NZ_CP049157	Caballeronia sp. SBC1 plasmid pSBC1_1, complete sequence	1529552-1529581	7	0.767
NZ_CP050993_7	7.10\|2306236\|30\|NZ_CP050993\|CRISPRCasFinder,PILER-CR	2306236-2306265	30	NZ_CP049317	Caballeronia sp. SBC2 plasmid pSBC2-1, complete sequence	114862-114891	7	0.767
NZ_CP050993_7	7.11\|2306313\|30\|NZ_CP050993\|CRISPRCasFinder,PILER-CR	2306313-2306342	30	AP013716	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C22-MedDCM-OCT-S38-C22, * SEQUENCING IN PROGRESS *	7470-7499	7	0.767
NZ_CP050993_6	6.4\|2300982\|35\|NZ_CP050993\|CRT	2300982-2301016	35	MN693725	Marine virus AFVG_250M494, complete genome	5103-5137	8	0.771
NZ_CP050993_6	6.4\|2300982\|35\|NZ_CP050993\|CRT	2300982-2301016	35	AP013655	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C24-MedDCM-OCT-S28-C120, * SEQUENCING IN PROGRESS *	7897-7931	8	0.771
NZ_CP050993_7	7.2\|2305774\|29\|NZ_CP050993\|PILER-CR	2305774-2305802	29	NZ_KY000061	Agrobacterium tumefaciens strain CFBP2413 plasmid pTi_CFBP2413, complete sequence	68934-68962	8	0.724
NZ_CP050993_7	7.2\|2305774\|29\|NZ_CP050993\|PILER-CR	2305774-2305802	29	NZ_CP026926	Agrobacterium tumefaciens strain 1D1609 plasmid pTi1D1609, complete sequence	152359-152387	8	0.724
NZ_CP050993_7	7.2\|2305774\|29\|NZ_CP050993\|PILER-CR	2305774-2305802	29	NZ_CP011249	Agrobacterium tumefaciens strain Ach5 plasmid pTi, complete sequence	93560-93588	8	0.724
NZ_CP050993_7	7.2\|2305774\|29\|NZ_CP050993\|PILER-CR	2305774-2305802	29	NC_002377	Agrobacterium tumefaciens plasmid Ti, complete sequence	93554-93582	8	0.724
NZ_CP050993_7	7.2\|2305774\|29\|NZ_CP050993\|PILER-CR	2305774-2305802	29	NZ_CP032920	Agrobacterium tumefaciens strain 15955 plasmid pTi15955, complete sequence	180505-180533	8	0.724
NZ_CP050993_7	7.2\|2305774\|29\|NZ_CP050993\|PILER-CR	2305774-2305802	29	NZ_CP033030	Agrobacterium tumefaciens strain A6 plasmid pTiA6, complete sequence	180505-180533	8	0.724
NZ_CP050993_7	7.2\|2305774\|29\|NZ_CP050993\|PILER-CR	2305774-2305802	29	NZ_KY000030	Agrobacterium genomosp. 1 strain CFBP5767 plasmid pTi_CFBP5767, complete sequence	59752-59780	8	0.724
NZ_CP050993_7	7.7\|2306005\|30\|NZ_CP050993\|CRISPRCasFinder,PILER-CR	2306005-2306034	30	NZ_CP039285	Leptospira interrogans strain FMAS_AW1 plasmid pLiSL2, complete sequence	89984-90013	8	0.733
NZ_CP050993_7	7.9\|2306159\|30\|NZ_CP050993\|CRISPRCasFinder,PILER-CR	2306159-2306188	30	NZ_CP015284	Streptococcus salivarius strain ATCC 25975 plasmid, complete sequence	64412-64441	8	0.733
NZ_CP050993_7	7.10\|2306236\|30\|NZ_CP050993\|CRISPRCasFinder,PILER-CR	2306236-2306265	30	NZ_CP020526	Enterobacter cloacae strain 109 plasmid unnamed1, complete sequence	16955-16984	8	0.733
NZ_CP050993_7	7.10\|2306236\|30\|NZ_CP050993\|CRISPRCasFinder,PILER-CR	2306236-2306265	30	NZ_CP021898	UNVERIFIED_ORG: Enterobacter cloacae strain AR_0050 plasmid unitig_3_pilon, complete sequence	58805-58834	8	0.733
NZ_CP050993_6	6.4\|2300982\|35\|NZ_CP050993\|CRT	2300982-2301016	35	CP013001	Bacillus thuringiensis strain XL6 plasmid, complete sequence	100628-100662	9	0.743
NZ_CP050993_7	7.4\|2305774\|30\|NZ_CP050993\|CRISPRCasFinder	2305774-2305803	30	NZ_KY000061	Agrobacterium tumefaciens strain CFBP2413 plasmid pTi_CFBP2413, complete sequence	68933-68962	9	0.7
NZ_CP050993_7	7.4\|2305774\|30\|NZ_CP050993\|CRISPRCasFinder	2305774-2305803	30	NZ_CP026926	Agrobacterium tumefaciens strain 1D1609 plasmid pTi1D1609, complete sequence	152359-152388	9	0.7
NZ_CP050993_7	7.4\|2305774\|30\|NZ_CP050993\|CRISPRCasFinder	2305774-2305803	30	NZ_CP011249	Agrobacterium tumefaciens strain Ach5 plasmid pTi, complete sequence	93560-93589	9	0.7
NZ_CP050993_7	7.4\|2305774\|30\|NZ_CP050993\|CRISPRCasFinder	2305774-2305803	30	NC_002377	Agrobacterium tumefaciens plasmid Ti, complete sequence	93554-93583	9	0.7
NZ_CP050993_7	7.4\|2305774\|30\|NZ_CP050993\|CRISPRCasFinder	2305774-2305803	30	NZ_CP032920	Agrobacterium tumefaciens strain 15955 plasmid pTi15955, complete sequence	180505-180534	9	0.7
NZ_CP050993_7	7.4\|2305774\|30\|NZ_CP050993\|CRISPRCasFinder	2305774-2305803	30	NZ_CP033030	Agrobacterium tumefaciens strain A6 plasmid pTiA6, complete sequence	180505-180534	9	0.7
NZ_CP050993_7	7.4\|2305774\|30\|NZ_CP050993\|CRISPRCasFinder	2305774-2305803	30	NZ_KY000030	Agrobacterium genomosp. 1 strain CFBP5767 plasmid pTi_CFBP5767, complete sequence	59752-59781	9	0.7
NZ_CP050993_7	7.8\|2306082\|30\|NZ_CP050993\|CRISPRCasFinder,PILER-CR	2306082-2306111	30	NZ_CP018001	Rhizobium sp. Y9 plasmid pY9, complete sequence	28445-28474	9	0.7
NZ_CP050993_3	3.2\|1627864\|34\|NZ_CP050993\|CRISPRCasFinder	1627864-1627897	34	NC_024991	Tetragenococcus halophilus plasmid pTDC-B DNA, complete sequence, strain: TyrB	18254-18287	10	0.706
NZ_CP050993_3	3.2\|1627864\|34\|NZ_CP050993\|CRISPRCasFinder	1627864-1627897	34	NC_024990	Tetragenococcus halophilus plasmid pTDC-A DNA, complete sequence, strain: TyrA	18254-18287	10	0.706

1. spacer 7.1|2305697|25|NZ_CP050993|PILER-CR matches to MN032614 (Aeromonas phage PS1, complete genome) position: , mismatch: 4, identity: 0.84

taataacaaaaaggtataatgtacc	CRISPR spacer
taataacaaaaaggtgaaatgtaga	Protospacer
***************. ******

2. spacer 7.2|2305774|29|NZ_CP050993|PILER-CR matches to JQ768459 (Pseudomonas phage Lu11, complete genome) position: , mismatch: 4, identity: 0.862

-ctattgagctggtgaagcaaatgcaggaa	CRISPR spacer
gctatc-agcaagtgaagcaaatgcaggaa	Protospacer
 ****. *** .******************

3. spacer 7.4|2305774|30|NZ_CP050993|CRISPRCasFinder matches to JQ768459 (Pseudomonas phage Lu11, complete genome) position: , mismatch: 5, identity: 0.833

-ctattgagctggtgaagcaaatgcaggaat	CRISPR spacer
gctatc-agcaagtgaagcaaatgcaggaaa	Protospacer
 ****. *** .******************

4. spacer 8.1|3295442|28|NZ_CP050993|CRISPRCasFinder matches to LQ581860 (Sequence 19 from Patent WO2016102829) position: , mismatch: 5, identity: 0.821

gttgggagttggaagaaggggcagagat	CRISPR spacer
gttgggaggtggcagaaggggcagccac	Protospacer
******** *** ***********  *.

5. spacer 8.1|3295442|28|NZ_CP050993|CRISPRCasFinder matches to LQ581858 (Sequence 17 from Patent WO2016102829) position: , mismatch: 5, identity: 0.821

gttgggagttggaagaaggggcagagat	CRISPR spacer
gttgggaggtggcagaaggggcagccac	Protospacer
******** *** ***********  *.

6. spacer 3.1|1627814|26|NZ_CP050993|CRISPRCasFinder matches to NZ_CP049159 (Caballeronia sp. SBC1 plasmid pSBC1_3, complete sequence) position: , mismatch: 6, identity: 0.769

tttcttcgagagcctcagactgacat	CRISPR spacer
gttcatcgagagcctcagactgcgtc	Protospacer
 *** *****************   .

7. spacer 3.1|1627814|26|NZ_CP050993|CRISPRCasFinder matches to NZ_CP049320 (Caballeronia sp. SBC2 plasmid pSBC2-4, complete sequence) position: , mismatch: 6, identity: 0.769

tttcttcgagagcctcagactgacat	CRISPR spacer
gttcatcgagagcctcagactgcgtc	Protospacer
 *** *****************   .

8. spacer 7.2|2305774|29|NZ_CP050993|PILER-CR matches to NZ_AP014659 (Bradyrhizobium diazoefficiens strain NK6 plasmid pNK6a, complete sequence) position: , mismatch: 6, identity: 0.793

ctattgagctggtgaagcaaatgcaggaa	CRISPR spacer
ccgttgagctggtgaagaatatgcaggct	Protospacer
*..************** * *******

9. spacer 7.2|2305774|29|NZ_CP050993|PILER-CR matches to NZ_CP027149 (Klebsiella pneumoniae strain AR_0363 plasmid unnamed8) position: , mismatch: 6, identity: 0.793

ctattgagctggtgaagcaaatgcaggaa	CRISPR spacer
ccgttgagctggcgaagcaactgcagggg	Protospacer
*..*********.******* ******..

10. spacer 7.2|2305774|29|NZ_CP050993|PILER-CR matches to NZ_CP049701 (Bradyrhizobium sp. 1S5 strain 323S2 plasmid pB323S2b, complete sequence) position: , mismatch: 6, identity: 0.793

ctattgagctggtgaagcaaatgcaggaa	CRISPR spacer
ccgttgagctggtgaagaatatgcaggct	Protospacer
*..************** * *******

11. spacer 7.5|2305851|30|NZ_CP050993|CRISPRCasFinder matches to NZ_LR134403 (Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence) position: , mismatch: 6, identity: 0.8

aatatc----gccgtaaaggcaaattaattggct	CRISPR spacer
----tcgtaagccgtaaaggtaaattacttggct	Protospacer
    **    **********.****** ******

12. spacer 7.7|2306005|30|NZ_CP050993|CRISPRCasFinder,PILER-CR matches to NC_042010 (Streptomyces phage Paradiddles, complete genome) position: , mismatch: 6, identity: 0.8

gaagcagctcaaagagactacaggaactac	CRISPR spacer
gagtcagttcaaagagactacagggactgg	Protospacer
**. ***.****************.***.

13. spacer 7.11|2306313|30|NZ_CP050993|CRISPRCasFinder,PILER-CR matches to MN693439 (Marine virus AFVG_25M521, complete genome) position: , mismatch: 6, identity: 0.8

aagcttatttacttgatatggctacaccta	CRISPR spacer
atggtagtttacttgctatggctactccta	Protospacer
* * * .******** ********* ****

14. spacer 7.11|2306313|30|NZ_CP050993|CRISPRCasFinder,PILER-CR matches to MN693531 (Marine virus AFVG_25M28, complete genome) position: , mismatch: 6, identity: 0.8

aagcttatttacttgatatggctacaccta	CRISPR spacer
atggtagtttacttgctatggctactccta	Protospacer
* * * .******** ********* ****

15. spacer 6.4|2300982|35|NZ_CP050993|CRT matches to NZ_CP013709 (Clostridium botulinum strain F634 plasmid pRSJ2_2, complete sequence) position: , mismatch: 7, identity: 0.8

aaatagaaataaaatgacaaatttattaaaagcat-	CRISPR spacer
aaatataaataaaatgataaattta-tattaatata	Protospacer
***** ***********.******* **  *..**

16. spacer 6.4|2300982|35|NZ_CP050993|CRT matches to NZ_CP013844 (Clostridium botulinum strain A634 plasmid pRSJ19_2, complete sequence) position: , mismatch: 7, identity: 0.8

aaatagaaataaaatgacaaatttattaaaagcat-	CRISPR spacer
aaatataaataaaatgataaattta-tattaatata	Protospacer
***** ***********.******* **  *..**

17. spacer 7.4|2305774|30|NZ_CP050993|CRISPRCasFinder matches to NZ_AP014659 (Bradyrhizobium diazoefficiens strain NK6 plasmid pNK6a, complete sequence) position: , mismatch: 7, identity: 0.767

ctattgagctggtgaagcaaatgcaggaat	CRISPR spacer
ccgttgagctggtgaagaatatgcaggctg	Protospacer
*..************** * *******

18. spacer 7.4|2305774|30|NZ_CP050993|CRISPRCasFinder matches to NZ_CP027149 (Klebsiella pneumoniae strain AR_0363 plasmid unnamed8) position: , mismatch: 7, identity: 0.767

ctattgagctggtgaagcaaatgcaggaat	CRISPR spacer
ccgttgagctggcgaagcaactgcaggggc	Protospacer
*..*********.******* ******...

19. spacer 7.4|2305774|30|NZ_CP050993|CRISPRCasFinder matches to NZ_CP049701 (Bradyrhizobium sp. 1S5 strain 323S2 plasmid pB323S2b, complete sequence) position: , mismatch: 7, identity: 0.767

ctattgagctggtgaagcaaatgcaggaat	CRISPR spacer
ccgttgagctggtgaagaatatgcaggctg	Protospacer
*..************** * *******

20. spacer 7.10|2306236|30|NZ_CP050993|CRISPRCasFinder,PILER-CR matches to NZ_CP049157 (Caballeronia sp. SBC1 plasmid pSBC1_1, complete sequence) position: , mismatch: 7, identity: 0.767

taaaaaatattgcaaaagtaggcgattccg	CRISPR spacer
aagaaaatattgcaaatggaggcgattgtc	Protospacer
 *.************* * ******** .

21. spacer 7.10|2306236|30|NZ_CP050993|CRISPRCasFinder,PILER-CR matches to NZ_CP049317 (Caballeronia sp. SBC2 plasmid pSBC2-1, complete sequence) position: , mismatch: 7, identity: 0.767

taaaaaatattgcaaaagtaggcgattccg	CRISPR spacer
aagaaaatattgcaaatggaggcgattgtc	Protospacer
 *.************* * ******** .

22. spacer 7.11|2306313|30|NZ_CP050993|CRISPRCasFinder,PILER-CR matches to AP013716 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C22-MedDCM-OCT-S38-C22, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.767

aagcttatttacttgatatggctacaccta-	CRISPR spacer
aagcttatgtacttgatatgg-aatactggg	Protospacer
******** ************  *.**. .

23. spacer 6.4|2300982|35|NZ_CP050993|CRT matches to MN693725 (Marine virus AFVG_250M494, complete genome) position: , mismatch: 8, identity: 0.771

aaatagaaataaaatgacaaatttattaaaagcat	CRISPR spacer
aaaactaaataaaatgaaagatttattaaaaccta	Protospacer
***   *********** *.*********** *

24. spacer 6.4|2300982|35|NZ_CP050993|CRT matches to AP013655 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C24-MedDCM-OCT-S28-C120, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 8, identity: 0.771

aaatagaaataaaatgacaaatttattaaaagcat	CRISPR spacer
aaaggaaaataaaatgataaattttttaaaattaa	Protospacer
*** ..***********.****** ****** .*

25. spacer 7.2|2305774|29|NZ_CP050993|PILER-CR matches to NZ_KY000061 (Agrobacterium tumefaciens strain CFBP2413 plasmid pTi_CFBP2413, complete sequence) position: , mismatch: 8, identity: 0.724

ctattgagctggtgaagcaaatgcaggaa	CRISPR spacer
tccttgagctgttgaagcaactgcagcgc	Protospacer
.. ******** ******** ***** .

26. spacer 7.2|2305774|29|NZ_CP050993|PILER-CR matches to NZ_CP026926 (Agrobacterium tumefaciens strain 1D1609 plasmid pTi1D1609, complete sequence) position: , mismatch: 8, identity: 0.724

ctattgagctggtgaagcaaatgcaggaa	CRISPR spacer
tccttgagctgttgaagcaactgcagcgc	Protospacer
.. ******** ******** ***** .

27. spacer 7.2|2305774|29|NZ_CP050993|PILER-CR matches to NZ_CP011249 (Agrobacterium tumefaciens strain Ach5 plasmid pTi, complete sequence) position: , mismatch: 8, identity: 0.724

ctattgagctggtgaagcaaatgcaggaa	CRISPR spacer
tccttgagctgttgaagcaactgcagcgc	Protospacer
.. ******** ******** ***** .

28. spacer 7.2|2305774|29|NZ_CP050993|PILER-CR matches to NC_002377 (Agrobacterium tumefaciens plasmid Ti, complete sequence) position: , mismatch: 8, identity: 0.724

ctattgagctggtgaagcaaatgcaggaa	CRISPR spacer
tccttgagctgttgaagcaactgcagcgc	Protospacer
.. ******** ******** ***** .

29. spacer 7.2|2305774|29|NZ_CP050993|PILER-CR matches to NZ_CP032920 (Agrobacterium tumefaciens strain 15955 plasmid pTi15955, complete sequence) position: , mismatch: 8, identity: 0.724

ctattgagctggtgaagcaaatgcaggaa	CRISPR spacer
tccttgagctgttgaagcaactgcagcgc	Protospacer
.. ******** ******** ***** .

30. spacer 7.2|2305774|29|NZ_CP050993|PILER-CR matches to NZ_CP033030 (Agrobacterium tumefaciens strain A6 plasmid pTiA6, complete sequence) position: , mismatch: 8, identity: 0.724

ctattgagctggtgaagcaaatgcaggaa	CRISPR spacer
tccttgagctgttgaagcaactgcagcgc	Protospacer
.. ******** ******** ***** .

31. spacer 7.2|2305774|29|NZ_CP050993|PILER-CR matches to NZ_KY000030 (Agrobacterium genomosp. 1 strain CFBP5767 plasmid pTi_CFBP5767, complete sequence) position: , mismatch: 8, identity: 0.724

ctattgagctggtgaagcaaatgcaggaa	CRISPR spacer
tccttgagctgttgaagcaactgcagcgc	Protospacer
.. ******** ******** ***** .

32. spacer 7.7|2306005|30|NZ_CP050993|CRISPRCasFinder,PILER-CR matches to NZ_CP039285 (Leptospira interrogans strain FMAS_AW1 plasmid pLiSL2, complete sequence) position: , mismatch: 8, identity: 0.733

gaagcagctcaaagagactacaggaactac	CRISPR spacer
aaagcatctcaaagagactaaaggtctcaa	Protospacer
.***** ************* ***  ..*

33. spacer 7.9|2306159|30|NZ_CP050993|CRISPRCasFinder,PILER-CR matches to NZ_CP015284 (Streptococcus salivarius strain ATCC 25975 plasmid, complete sequence) position: , mismatch: 8, identity: 0.733

aactcgagataacatttgtaaaaaaacata	CRISPR spacer
ttatagatataacatttgtaaaaaaagagc	Protospacer
   * ** ****************** *

34. spacer 7.10|2306236|30|NZ_CP050993|CRISPRCasFinder,PILER-CR matches to NZ_CP020526 (Enterobacter cloacae strain 109 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

taaaaaatattgcaaaagtaggcgattccg	CRISPR spacer
acagaaatattgcaaatgtcggcgattgtc	Protospacer
  *.************ ** ******* .

35. spacer 7.10|2306236|30|NZ_CP050993|CRISPRCasFinder,PILER-CR matches to NZ_CP021898 (UNVERIFIED_ORG: Enterobacter cloacae strain AR_0050 plasmid unitig_3_pilon, complete sequence) position: , mismatch: 8, identity: 0.733

taaaaaatattgcaaaagtaggcgattccg	CRISPR spacer
acagaaatattgcaaatgtcggcgattgtc	Protospacer
  *.************ ** ******* .

36. spacer 6.4|2300982|35|NZ_CP050993|CRT matches to CP013001 (Bacillus thuringiensis strain XL6 plasmid, complete sequence) position: , mismatch: 9, identity: 0.743

aaatagaaataaaatgacaaatttattaaaagcat	CRISPR spacer
ttaatgaaataaaatgccaaatttatgaaacacag	Protospacer
  *  *********** ********* *** .**

37. spacer 7.4|2305774|30|NZ_CP050993|CRISPRCasFinder matches to NZ_KY000061 (Agrobacterium tumefaciens strain CFBP2413 plasmid pTi_CFBP2413, complete sequence) position: , mismatch: 9, identity: 0.7

ctattgagctggtgaagcaaatgcaggaat	CRISPR spacer
tccttgagctgttgaagcaactgcagcgcg	Protospacer
.. ******** ******** ***** .

38. spacer 7.4|2305774|30|NZ_CP050993|CRISPRCasFinder matches to NZ_CP026926 (Agrobacterium tumefaciens strain 1D1609 plasmid pTi1D1609, complete sequence) position: , mismatch: 9, identity: 0.7

ctattgagctggtgaagcaaatgcaggaat	CRISPR spacer
tccttgagctgttgaagcaactgcagcgcg	Protospacer
.. ******** ******** ***** .

39. spacer 7.4|2305774|30|NZ_CP050993|CRISPRCasFinder matches to NZ_CP011249 (Agrobacterium tumefaciens strain Ach5 plasmid pTi, complete sequence) position: , mismatch: 9, identity: 0.7

ctattgagctggtgaagcaaatgcaggaat	CRISPR spacer
tccttgagctgttgaagcaactgcagcgcg	Protospacer
.. ******** ******** ***** .

40. spacer 7.4|2305774|30|NZ_CP050993|CRISPRCasFinder matches to NC_002377 (Agrobacterium tumefaciens plasmid Ti, complete sequence) position: , mismatch: 9, identity: 0.7

ctattgagctggtgaagcaaatgcaggaat	CRISPR spacer
tccttgagctgttgaagcaactgcagcgcg	Protospacer
.. ******** ******** ***** .

41. spacer 7.4|2305774|30|NZ_CP050993|CRISPRCasFinder matches to NZ_CP032920 (Agrobacterium tumefaciens strain 15955 plasmid pTi15955, complete sequence) position: , mismatch: 9, identity: 0.7

ctattgagctggtgaagcaaatgcaggaat	CRISPR spacer
tccttgagctgttgaagcaactgcagcgcg	Protospacer
.. ******** ******** ***** .

42. spacer 7.4|2305774|30|NZ_CP050993|CRISPRCasFinder matches to NZ_CP033030 (Agrobacterium tumefaciens strain A6 plasmid pTiA6, complete sequence) position: , mismatch: 9, identity: 0.7

ctattgagctggtgaagcaaatgcaggaat	CRISPR spacer
tccttgagctgttgaagcaactgcagcgcg	Protospacer
.. ******** ******** ***** .

43. spacer 7.4|2305774|30|NZ_CP050993|CRISPRCasFinder matches to NZ_KY000030 (Agrobacterium genomosp. 1 strain CFBP5767 plasmid pTi_CFBP5767, complete sequence) position: , mismatch: 9, identity: 0.7

ctattgagctggtgaagcaaatgcaggaat	CRISPR spacer
tccttgagctgttgaagcaactgcagcgcg	Protospacer
.. ******** ******** ***** .

44. spacer 7.8|2306082|30|NZ_CP050993|CRISPRCasFinder,PILER-CR matches to NZ_CP018001 (Rhizobium sp. Y9 plasmid pY9, complete sequence) position: , mismatch: 9, identity: 0.7

gctgcgcagcttgtaattatttcgaatctt	CRISPR spacer
tatgcgcagattgtaattattacgatgagc	Protospacer
  ******* *********** ***    .

45. spacer 3.2|1627864|34|NZ_CP050993|CRISPRCasFinder matches to NC_024991 (Tetragenococcus halophilus plasmid pTDC-B DNA, complete sequence, strain: TyrB) position: , mismatch: 10, identity: 0.706

atattaatactaaaattgaaacttcaaattagaa	CRISPR spacer
tggttaatactgaaattgaatcttcaaaacgtca	Protospacer
  .********.******** ******* ..  *

46. spacer 3.2|1627864|34|NZ_CP050993|CRISPRCasFinder matches to NC_024990 (Tetragenococcus halophilus plasmid pTDC-A DNA, complete sequence, strain: TyrA) position: , mismatch: 10, identity: 0.706

atattaatactaaaattgaaacttcaaattagaa	CRISPR spacer
tggttaatactgaaattgaatcttcaaaacgtca	Protospacer
  .********.******** ******* ..  *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

678532 : 723543

Paramecium_bursaria_Chlorella_virus(14.29%)

transposase,integrase

attL 685334:685351|attR 728085:728102

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_076781753.1\|678532_678958_-\|transposase	transposase	NA	NA	NA	NA
WP_168637755.1\|679118_679673_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_168637756.1\|679689_680883_+	argininosuccinate synthase	NA	NA	NA	NA
WP_168637757.1\|681145_682111_+	N-acetyl-gamma-glutamyl-phosphate reductase	NA	NA	NA	NA
WP_168637758.1\|682238_683411_+	aminotransferase class III-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_168637759.1\|683546_684524_+	acetylornithine carbamoyltransferase	NA	NA	NA	NA
WP_168637760.1\|684676_685468_+	acetylglutamate kinase	NA	NA	NA	NA
685334:685351	attL	NA	NA	NA	NA
WP_168637761.1\|685442_686525_+	M20 family metallo-hydrolase	NA	NA	NA	NA
WP_168637762.1\|686976_688281_+	argininosuccinate lyase	NA	NA	NA	NA
WP_168637763.1\|688388_688850_-	Lrp/AsnC family transcriptional regulator	NA	NA	NA	NA
WP_168637764.1\|689102_690005_+	aspartate carbamoyltransferase catalytic subunit	A7RB08	Paramecium_bursaria_Chlorella_virus	3.7e-28	31.0
WP_168637765.1\|690120_691194_+	glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit	R4TGJ8	Halovirus	1.2e-54	34.8
WP_168637766.1\|691414_694594_+	carbamoyl-phosphate synthase large subunit	NA	NA	NA	NA
WP_168637767.1\|694719_695985_+	sugar MFS transporter	NA	NA	NA	NA
WP_076781739.1\|696041_696350_+	hypothetical protein	NA	NA	NA	NA
WP_168637768.1\|696464_698606_-	DNA mismatch repair protein MutS	NA	NA	NA	NA
WP_168637769.1\|699045_699249_+	DUF2945 domain-containing protein	NA	NA	NA	NA
WP_168637770.1\|699322_700690_+	aldehyde dehydrogenase	NA	NA	NA	NA
WP_168637771.1\|700735_700966_-	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_168637772.1\|700994_702302_-	voltage-gated chloride channel family protein	A0A1X9I5Z9	Streptococcus_phage	9.1e-36	30.6
WP_168637773.1\|702500_703358_-	GLPGLI family protein	NA	NA	NA	NA
WP_168639647.1\|703630_705265_-	MFS transporter	NA	NA	NA	NA
WP_168637774.1\|705367_706489_-	HlyD family secretion protein	NA	NA	NA	NA
WP_168637775.1\|706509_707820_-	TolC family protein	NA	NA	NA	NA
WP_076784491.1\|707912_708755_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_088263489.1\|709151_710705_+\|transposase	IS1182 family transposase	NA	NA	NA	NA
WP_055041555.1\|713338_713623_-	putative addiction module antidote protein	A4JWV1	Burkholderia_virus	5.2e-13	45.5
WP_124784682.1\|713626_713926_-	type II toxin-antitoxin system RelE/ParE family toxin	A0A141GEX6	Brucella_phage	2.6e-15	42.3
WP_088263489.1\|714328_715882_+\|transposase	IS1182 family transposase	NA	NA	NA	NA
WP_168637776.1\|716027_716525_-	hypothetical protein	NA	NA	NA	NA
WP_168637777.1\|716508_716934_-	hypothetical protein	NA	NA	NA	NA
WP_088263489.1\|717036_718590_+\|transposase	IS1182 family transposase	NA	NA	NA	NA
WP_168639648.1\|718843_719746_+\|integrase	tyrosine-type recombinase/integrase	S5W9T9	Leptospira_phage	1.8e-35	33.1
WP_168637778.1\|721206_721878_-	hypothetical protein	NA	NA	NA	NA
WP_168637779.1\|722325_723543_+\|integrase	site-specific integrase	H7BUI8	unidentified_phage	2.8e-15	25.7
728085:728102	attR	NA	NA	NA	NA

DBSCAN-SWA_2

1056754 : 1080871

uncultured_Mediterranean_phage(33.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_168637986.1\|1056754_1057228_+\|transposase	IS200/IS605 family transposase	NA	NA	NA	NA
WP_076782103.1\|1057477_1057981_+	hypothetical protein	NA	NA	NA	NA
WP_168637987.1\|1058018_1061714_+	phosphoribosylformylglycinamidine synthase	NA	NA	NA	NA
WP_168637988.1\|1061888_1062767_+\|transposase	IS982 family transposase	NA	NA	NA	NA
WP_168637989.1\|1062805_1064206_-	TolC family protein	NA	NA	NA	NA
WP_168637990.1\|1064189_1065494_-	HlyD family efflux transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_168637991.1\|1065502_1067170_-	ABC transporter ATP-binding protein	NA	NA	NA	NA
WP_168637992.1\|1067309_1067789_-	hypothetical protein	NA	NA	NA	NA
WP_088263489.1\|1069834_1071388_+\|transposase	IS1182 family transposase	NA	NA	NA	NA
WP_168637993.1\|1071537_1072152_-	HNH endonuclease	NA	NA	NA	NA
WP_168637994.1\|1072338_1072569_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_089770588.1\|1072648_1073530_+\|transposase	IS982 family transposase	NA	NA	NA	NA
WP_168639664.1\|1074061_1076584_-	excinuclease ABC subunit UvrA	A0A1B1IVR3	uncultured_Mediterranean_phage	1.1e-159	35.3
WP_168637995.1\|1076996_1077731_+\|transposase	transposase	Q9MBP7	Staphylococcus_prophage	3.2e-22	34.8
WP_168637996.1\|1077752_1078082_+	hypothetical protein	A0A146ICT8	Staphylococcus_phage	5.1e-12	54.8
WP_168637997.1\|1078353_1078986_-	NAD(P)H-dependent oxidoreductase	NA	NA	NA	NA
WP_168639665.1\|1078993_1079362_-	DUF1304 domain-containing protein	NA	NA	NA	NA
WP_168637998.1\|1079370_1079793_-	organic hydroperoxide resistance protein	NA	NA	NA	NA
WP_168637999.1\|1079992_1080871_-\|transposase	IS982 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

2288429 : 2365387

Leptospira_phage(33.33%)

transposase,integrase

attL 2325710:2325769|attR 2336475:2336564

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_076554317.1\|2288429_2289770_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_168638819.1\|2290810_2291140_+	hypothetical protein	NA	NA	NA	NA
WP_168638820.1\|2291153_2291909_+	GLPGLI family protein	NA	NA	NA	NA
WP_168638821.1\|2291886_2294559_+	TonB-dependent receptor	NA	NA	NA	NA
WP_168638822.1\|2294555_2295209_-	TraM recognition domain-containing protein	NA	NA	NA	NA
WP_168638823.1\|2295233_2295629_+	amidohydrolase family protein	NA	NA	NA	NA
WP_168638824.1\|2296829_2297273_+	hypothetical protein	NA	NA	NA	NA
WP_168638825.1\|2297306_2298149_+	NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_168638826.1\|2298167_2299019_+	hypothetical protein	NA	NA	NA	NA
WP_168638827.1\|2299026_2300259_-	MFS transporter	NA	NA	NA	NA
WP_168639709.1\|2301057_2301180_+	GlsB/YeaQ/YmgE family stress response membrane protein	NA	NA	NA	NA
WP_168638828.1\|2301230_2304116_+	T9SS type A sorting domain-containing protein	NA	NA	NA	NA
WP_168638829.1\|2306609_2307728_-	DUF3320 domain-containing protein	NA	NA	NA	NA
WP_168638830.1\|2307685_2308063_-	hypothetical protein	NA	NA	NA	NA
WP_168638831.1\|2308014_2312418_-	DUF4011 domain-containing protein	NA	NA	NA	NA
WP_168638832.1\|2312481_2312820_-	CRISPR-associated endonuclease Cas2	NA	NA	NA	NA
WP_168638833.1\|2312862_2313765_-	type II CRISPR-associated endonuclease Cas1	NA	NA	NA	NA
WP_168638834.1\|2313772_2314219_-	PIN domain-containing protein	NA	NA	NA	NA
WP_168638835.1\|2314190_2318480_-	type II CRISPR RNA-guided endonuclease Cas9	NA	NA	NA	NA
WP_168638836.1\|2318882_2319086_-	hypothetical protein	NA	NA	NA	NA
WP_168639710.1\|2319409_2319922_-	hypothetical protein	NA	NA	NA	NA
WP_168637941.1\|2320571_2321918_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_168638837.1\|2322006_2322267_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_168638838.1\|2322469_2323249_+	hypothetical protein	NA	NA	NA	NA
WP_168639711.1\|2324774_2325677_-\|integrase	tyrosine-type recombinase/integrase	S5W9T9	Leptospira_phage	1.6e-34	32.4
2325710:2325769	attL	NA	NA	NA	NA
WP_168638839.1\|2326080_2327181_+	AccI family restriction endonuclease	NA	NA	NA	NA
WP_168638840.1\|2327180_2328806_+	methyltransferase	NA	NA	NA	NA
WP_124802118.1\|2330256_2331159_-\|integrase	tyrosine-type recombinase/integrase	S5W9T9	Leptospira_phage	5.3e-35	33.1
WP_123280865.1\|2331482_2332697_+	peptidase M1	NA	NA	NA	NA
WP_168638841.1\|2334805_2335633_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_076784530.1\|2335712_2336321_+	YkgB family protein	NA	NA	NA	NA
WP_076784583.1\|2336962_2337214_+	type II toxin-antitoxin system ParD family antitoxin	NA	NA	NA	NA
2336475:2336564	attR	NA	NA	NA	NA
WP_168638842.1\|2337206_2337506_+	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_076784580.1\|2337691_2337946_+	type II toxin-antitoxin system prevent-host-death family antitoxin	NA	NA	NA	NA
WP_168638843.1\|2337947_2338205_+	Txe/YoeB family addiction module toxin	NA	NA	NA	NA
WP_168638844.1\|2338874_2339057_+	hypothetical protein	NA	NA	NA	NA
WP_168638845.1\|2339544_2341284_+	ubiquinone-dependent pyruvate dehydrogenase	NA	NA	NA	NA
WP_168638846.1\|2341340_2341862_+	DUF1440 domain-containing protein	NA	NA	NA	NA
WP_168639712.1\|2342194_2342698_+	cupin domain-containing protein	NA	NA	NA	NA
WP_168638847.1\|2342704_2343373_+	NAD(P)-binding domain-containing protein	NA	NA	NA	NA
WP_168639713.1\|2343386_2343776_+	DoxX family membrane protein	NA	NA	NA	NA
WP_168638848.1\|2343803_2344310_+	DNA-binding protein	NA	NA	NA	NA
WP_168638849.1\|2344365_2345358_+	alpha/beta hydrolase	A0A2K9KZN8	Tupanvirus	9.7e-14	37.4
WP_168638850.1\|2345370_2346165_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_168638851.1\|2346191_2347136_+	aldo/keto reductase	NA	NA	NA	NA
WP_168638852.1\|2347199_2348372_+	MFS transporter	NA	NA	NA	NA
WP_168638853.1\|2348493_2349237_+	dienelactone hydrolase family protein	NA	NA	NA	NA
WP_168638854.1\|2349266_2350397_-	ATP-binding protein	NA	NA	NA	NA
WP_168638855.1\|2350604_2351855_-	CinA family nicotinamide mononucleotide deamidase-related protein	NA	NA	NA	NA
WP_168638856.1\|2352037_2353252_+	dicarboxylate/amino acid:cation symporter	NA	NA	NA	NA
WP_168638857.1\|2353530_2353920_-	DUF779 domain-containing protein	NA	NA	NA	NA
WP_168638858.1\|2354140_2355175_-	alcohol dehydrogenase AdhP	A0A2K9L339	Tupanvirus	7.0e-39	29.7
WP_168638859.1\|2355416_2356946_-	aldehyde dehydrogenase	NA	NA	NA	NA
WP_168638860.1\|2357156_2358080_+	AraC family transcriptional regulator	NA	NA	NA	NA
WP_168638861.1\|2358168_2359500_-	hydroxymethylglutaryl-CoA synthase family protein	NA	NA	NA	NA
WP_168638862.1\|2359654_2360998_-	ammonium transporter	H8ZJB2	Ostreococcus_tauri_virus	2.8e-32	28.9
WP_076784405.1\|2361170_2361359_+	hypothetical protein	NA	NA	NA	NA
WP_076784607.1\|2361566_2362793_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_168638863.1\|2362957_2364244_-	adenylosuccinate synthase	L7Y4J5	Megavirus	6.2e-69	35.3
WP_168638864.1\|2364508_2365387_-\|transposase	IS982 family transposase	NA	NA	NA	NA

DBSCAN-SWA_4

2452433 : 2507024

Hokovirus(11.11%)

tRNA,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_168637941.1\|2452433_2453780_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_168638932.1\|2453866_2454712_-	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_076781958.1\|2454716_2455061_-	phosphomannose isomerase type II C-terminal cupin domain	A0A1V0SH58	Hokovirus	3.2e-25	52.3
WP_168638933.1\|2455217_2456726_+\|tRNA	glutamate--tRNA ligase	NA	NA	NA	NA
WP_089768879.1\|2456791_2457748_+	acetyl-CoA carboxylase carboxyltransferase subunit alpha	NA	NA	NA	NA
WP_089768881.1\|2458018_2458780_-	30S ribosomal protein S2	NA	NA	NA	NA
WP_089768883.1\|2458988_2459375_-	30S ribosomal protein S9	NA	NA	NA	NA
WP_089768885.1\|2459381_2459837_-	50S ribosomal protein L13	NA	NA	NA	NA
WP_124986562.1\|2460469_2461783_+\|transposase	IS1380 family transposase	NA	NA	NA	NA
WP_124986562.1\|2462026_2463340_-\|transposase	IS1380 family transposase	NA	NA	NA	NA
WP_168639718.1\|2463468_2463801_-	hypothetical protein	NA	NA	NA	NA
WP_076781951.1\|2464177_2465356_+	nicotinate phosphoribosyltransferase	A0A2L0UZQ6	Agrobacterium_phage	5.7e-37	29.9
WP_168638934.1\|2465488_2466013_-	DUF4252 domain-containing protein	NA	NA	NA	NA
WP_168638935.1\|2466016_2467342_-	DUF4252 domain-containing protein	NA	NA	NA	NA
WP_168638936.1\|2467387_2468089_-	hypothetical protein	NA	NA	NA	NA
WP_168638938.1\|2468054_2468573_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_168639719.1\|2468827_2470045_-	beta-lactamase family protein	Q19XB5	Mycobacterium_phage	5.9e-13	27.6
WP_168638940.1\|2470200_2471130_-	hydroxyacid dehydrogenase	A0A1V0SBV6	Catovirus	8.5e-36	32.4
WP_168639720.1\|2471175_2471556_-	GxxExxY protein	A0A0P0YNF4	Yellowstone_lake_phycodnavirus	3.3e-10	37.5
WP_076781944.1\|2471596_2472118_-	acyl-CoA thioesterase	NA	NA	NA	NA
WP_168638941.1\|2472089_2472788_-	hypothetical protein	NA	NA	NA	NA
WP_168638942.1\|2472939_2475063_-	TonB-dependent receptor	NA	NA	NA	NA
WP_168638944.1\|2475299_2475965_-	WG repeat-containing protein	NA	NA	NA	NA
WP_168638945.1\|2475979_2476405_-	DUF2752 domain-containing protein	NA	NA	NA	NA
WP_168638947.1\|2476678_2479462_+	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase	NA	NA	NA	NA
WP_168638948.1\|2479713_2481984_+	aconitate hydratase	NA	NA	NA	NA
WP_168639721.1\|2482038_2482365_-	hypothetical protein	NA	NA	NA	NA
WP_168638949.1\|2482416_2482992_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_168638950.1\|2483124_2485284_+	outer membrane beta-barrel protein	NA	NA	NA	NA
WP_168637941.1\|2485396_2486743_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_168638952.1\|2486808_2487501_-	RNA pseudouridine synthase	NA	NA	NA	NA
WP_076781930.1\|2487505_2487832_-	hypothetical protein	NA	NA	NA	NA
WP_076781928.1\|2487921_2488737_-	3-methyl-2-oxobutanoate hydroxymethyltransferase	NA	NA	NA	NA
WP_168638953.1\|2488845_2489559_-	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
WP_168638954.1\|2489654_2492033_+	HAD-IC family P-type ATPase	A0A218MNH6	uncultured_virus	3.0e-53	26.3
WP_168638955.1\|2492142_2492331_+	cbb3-type cytochrome oxidase assembly protein CcoS	NA	NA	NA	NA
WP_076781924.1\|2492346_2494632_+	cytochrome-c oxidase, cbb3-type subunit I	NA	NA	NA	NA
WP_076781923.1\|2494643_2494856_+	cytochrome C oxidase Cbb3	NA	NA	NA	NA
WP_168638956.1\|2494874_2495753_+	c-type cytochrome	NA	NA	NA	NA
WP_076781921.1\|2495868_2497323_+	cytochrome c oxidase accessory protein CcoG	NA	NA	NA	NA
WP_168638957.1\|2497331_2497781_+	nitrogen fixation protein FixH	NA	NA	NA	NA
WP_076781919.1\|2497771_2498509_+	sulfite exporter TauE/SafE family protein	NA	NA	NA	NA
WP_168638958.1\|2498553_2499027_-	M penetrans family 1 protein	NA	NA	NA	NA
WP_076781917.1\|2499079_2499790_-	TIGR00730 family Rossman fold protein	A0A1D8KUT5	Synechococcus_phage	9.1e-22	38.5
WP_076781916.1\|2499786_2500500_-	NTP transferase domain-containing protein	NA	NA	NA	NA
WP_168638959.1\|2500496_2500922_-	ATP-binding protein	NA	NA	NA	NA
WP_168638960.1\|2501072_2502245_+	hypothetical protein	NA	NA	NA	NA
WP_168638961.1\|2502246_2502783_+	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	4.9e-20	34.1
WP_076781912.1\|2502864_2503569_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_168638962.1\|2503573_2504065_+	6,7-dimethyl-8-ribityllumazine synthase	NA	NA	NA	NA
WP_076781910.1\|2504228_2505080_+\|protease	metalloprotease	A0A1I9SA48	Rhodococcus_phage	7.5e-39	40.3
WP_076781909.1\|2505118_2505676_+	TlpA family protein disulfide reductase	NA	NA	NA	NA
WP_168638963.1\|2505683_2507024_-\|transposase	IS5 family transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP050993

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CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection