CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP050994	Aeromonas hydrophila strain NEB724 chromosome, complete genome	24 crisprs	DEDDh,WYL,DinG,csa3	1	2	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP050994_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_1

208448-208547

Orphan

Consensus_repeat	Method
CTTACAGACCCAACTTCTTGTGCAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_1

>merge|NZ_CP050994|1|208448-208547|CRISPRCasFinder
CTTACAGACCCAACTTCTTGTGCAGATGGTGGCTGTTAATGCCACCGTGCGGCAAGTTATCGGGTCCTGGCACCTCTTACAGACCCAACTTCTTGTGCAG

>NZ_CP050994|1|1|208448-208547|CRISPRCasFinder
CTTACAGACCCAACTTCTTGTGCAG	ATGGTGGCTGTTAATGCCACCGTGCGGCAAGTTATCGGGTCCTGGCACCT
CTTACAGACCCAACTTCTTGTGCAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_168234507.1\|201644_202523_-\|50S-ribosomal-protein-L11-methyltransferase	unknown	unknown	gnl\|CDD\|283886
NZ_CP050994.1\|WP_168234506.1\|200818_201388_-\|sugar-O-acetyltransferase	unknown	unknown	gnl\|CDD\|100047
NZ_CP050994.1\|WP_168234514.1\|218829_219993_-\|pentaheme-c-type-cytochrome-TorC	unknown	unknown	gnl\|CDD\|184992
NZ_CP050994.1\|WP_168234504.1\|197690_199718_+\|NADPH-dependent-2,4-dienoyl-CoA-reductase	unknown	unknown	gnl\|CDD\|239240
NZ_CP050994.1\|WP_168234515.1\|221997_224829_+\|TMAO-reductase-system-sensor-histidine-kinase/response-regulator-TorS	unknown	unknown	gnl\|CDD\|274362
NZ_CP050994.1\|WP_168234505.1\|199861_200410_+\|NAD(P)H-nitroreductase	unknown	unknown	gnl\|CDD\|182761
NZ_CP050994.1\|WP_168234512.1\|211111_213058_-\|acetate--CoA-ligase	unknown	unknown	gnl\|CDD\|234677
NZ_CP050994.1\|WP_168234509.1\|204159_205032_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NZ_CP050994.1\|WP_106887644.1\|215541_216210_-\|molecular-chaperone-TorD	unknown	unknown	gnl\|CDD\|235326
NZ_CP050994.1\|WP_168234508.1\|203042_204059_-\|zinc-binding-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|176214
NZ_CP050994.1\|WP_005326561.1\|210377_210827_-\|type-II-3-dehydroquinate-dehydratase	unknown	unknown	gnl\|CDD\|235443
NZ_CP050994.1\|WP_168234516.1\|224832_225159_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_168234511.1\|206545_208003_-\|sodium/pantothenate-symporter	unknown	unknown	gnl\|CDD\|236519
NZ_CP050994.1\|WP_168234510.1\|205032_206457_-\|PTS-transporter-subunit-EIIC	unknown	unknown	gnl\|CDD\|273920
NZ_CP050994.1\|WP_106887645.1\|215165_215534_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_139745181.1\|220144_220858_+\|two-component-system-response-regulator-TorR	unknown	unknown	gnl\|CDD\|182711
NZ_CP050994.1\|WP_025326015.1\|209879_210341_-\|acetyl-CoA-carboxylase-biotin-carboxyl-carrier-protein	unknown	unknown	gnl\|CDD\|235777
NZ_CP050994.1\|WP_041204435.1\|208086_208335_-\|YhdT-family-protein	unknown	unknown	gnl\|CDD\|377626
NZ_CP050994.1\|WP_168234503.1\|195420_197265_-\|signal-peptide-peptidase-SppA	unknown	unknown	gnl\|CDD\|182860
NZ_CP050994.1\|WP_168234513.1\|216309_218802_-\|trimethylamine-N-oxide-reductase-TorA	unknown	unknown	gnl\|CDD\|237909

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_168234507.1\|201644_202523_-\|50S-ribosomal-protein-L11-methyltransferase	gnl\|CDD\|283886	pfam06325, PrmA, Ribosomal protein L11 methyltransferase (PrmA). This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.	6.49907e-140
NZ_CP050994.1\|WP_168234506.1\|200818_201388_-\|sugar-O-acetyltransferase	gnl\|CDD\|100047	cd03357, LbH_MAT_GAT, Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6 position of the nonreducing end glucosyl moiety. GAT specifically acetylates galactopyranosides. Furthermore, MAT shows higher affinity toward artificial substrates containing an alkyl or hydrophobic chain as well as a glucosyl unit. Active MAT and GAT are homotrimers, with each subunit consisting of an N-terminal alpha-helical region and a C-terminal left-handed parallel alpha-helix (LbH) subdomain with 6 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X).	3.78551e-89
NZ_CP050994.1\|WP_168234514.1\|218829_219993_-\|pentaheme-c-type-cytochrome-TorC	gnl\|CDD\|184992	PRK15032, PRK15032, pentaheme c-type cytochrome TorC.	0
NZ_CP050994.1\|WP_168234504.1\|197690_199718_+\|NADPH-dependent-2,4-dienoyl-CoA-reductase	gnl\|CDD\|239240	cd02930, DCR_FMN, 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the flavin and iron-sulfur cofactors. Metabolism of unsaturated fatty acids requires auxiliary enzymes in addition to those used in b-oxidation. After a given number of cycles through the b-oxidation pathway, those unsaturated fatty acyl-CoAs with double bonds at even-numbered carbon positions contain 2-trans, 4-cis double bonds that can not be modified by enoyl-CoA hydratase. DCR utilizes NADPH to remove the C4-C5 double bond. DCR can catalyze the reduction of both natural fatty acids with cis double bonds, as well as substrates containing trans double bonds. The reaction is initiated by hybrid transfer from NADPH to FAD, which in turn transfers electrons, one at a time, to FMN via the 4Fe-4S cluster. The fully reduced FMN provides a hydrid ion to the C5 atom of substrate, and Tyr and His are proposed to form a catalytic dyad that protonates the C4 atom of the substrate and completes the reaction.	0
NZ_CP050994.1\|WP_168234515.1\|221997_224829_+\|TMAO-reductase-system-sensor-histidine-kinase/response-regulator-TorS	gnl\|CDD\|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	0
NZ_CP050994.1\|WP_168234505.1\|199861_200410_+\|NAD(P)H-nitroreductase	gnl\|CDD\|182761	PRK10828, PRK10828, putative oxidoreductase; Provisional.	8.60314e-87
NZ_CP050994.1\|WP_168234512.1\|211111_213058_-\|acetate--CoA-ligase	gnl\|CDD\|234677	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional.	0
NZ_CP050994.1\|WP_168234509.1\|204159_205032_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.84739e-73
NZ_CP050994.1\|WP_106887644.1\|215541_216210_-\|molecular-chaperone-TorD	gnl\|CDD\|235326	PRK04976, torD, chaperone protein TorD; Validated.	3.62743e-60
NZ_CP050994.1\|WP_168234508.1\|203042_204059_-\|zinc-binding-alcohol-dehydrogenase-family-protein	gnl\|CDD\|176214	cd08252, AL_MDR, Arginate lyase and other MDR family members. This group contains a structure identified as an arginate lyase. Other members are identified quinone reductases, alginate lyases, and other proteins related to the zinc-dependent dehydrogenases/reductases. QOR catalyzes the conversion of a quinone and NAD(P)H to a hydroquinone and NAD(P+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	0
NZ_CP050994.1\|WP_005326561.1\|210377_210827_-\|type-II-3-dehydroquinate-dehydratase	gnl\|CDD\|235443	PRK05395, PRK05395, type II 3-dehydroquinate dehydratase.	2.51838e-97
NZ_CP050994.1\|WP_168234511.1\|206545_208003_-\|sodium/pantothenate-symporter	gnl\|CDD\|236519	PRK09442, panF, sodium/pantothenate symporter.	0
NZ_CP050994.1\|WP_168234510.1\|205032_206457_-\|PTS-transporter-subunit-EIIC	gnl\|CDD\|273920	TIGR01998, N-acetylglucosamine_and_glucose_PTS, PTS system, N-acetylglucosamine-specific IIBC component. This model represents the combined B and C domains of the PTS transport system enzyme II specific for N-acetylglucosamine transport. Many of the genes in this family also include an A domain as part of the same polypeptide and thus should be given the name "PTS system, N-acetylglucosamine-specific IIABC component". This family is most closely related to the glucose-specific PTS enzymes. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	1.18187e-91
NZ_CP050994.1\|WP_168234513.1\|216309_218802_-\|trimethylamine-N-oxide-reductase-TorA	gnl\|CDD\|237909	PRK15102, PRK15102, trimethylamine-N-oxide reductase TorA.	0
NZ_CP050994.1\|WP_139745181.1\|220144_220858_+\|two-component-system-response-regulator-TorR	gnl\|CDD\|182711	PRK10766, PRK10766, two-component system response regulator TorR.	4.22238e-133
NZ_CP050994.1\|WP_025326015.1\|209879_210341_-\|acetyl-CoA-carboxylase-biotin-carboxyl-carrier-protein	gnl\|CDD\|235777	PRK06302, PRK06302, acetyl-CoA carboxylase biotin carboxyl carrier protein.	1.76857e-79
NZ_CP050994.1\|WP_041204435.1\|208086_208335_-\|YhdT-family-protein	gnl\|CDD\|377626	pfam06196, DUF997, Protein of unknown function (DUF997). Family of predicted bacterial membrane protein with unknown function.	1.06978e-20
NZ_CP050994.1\|WP_168234503.1\|195420_197265_-\|signal-peptide-peptidase-SppA	gnl\|CDD\|182860	PRK10949, PRK10949, signal peptide peptidase SppA.	0

>NZ_CP050994.1|WP_041204435.1|208086_208335_-|YhdT-family-protein
MNRFALARREAALCLLLTLLYFVAWYGTAYFIPEELELWDMPLWFLLSCMLMPLLFIGLCALMVDRLFIDIPLDTEEPPHES
>NZ_CP050994.1|WP_168234511.1|206545_208003_-|sodium/pantothenate-symporter
MNLELMLPLVIYLVLVLGVGFWAGRHRAGGDFVQEYFIGNRSMGGLVLAMTLVATYTSASSFIGGPGAAYKIGLGWVLLAMIQLPTVWLTLGVLGKKFAIIARRVNAVTINDMLWARYRSKWVVVLGSVTIILAFIATMVVQFIGGARLLETATGLSYQQGLFLFASCVLLYTVIGGFRAVVMTDALQGIIMLIGTGALLAGILIAGDGLPNLIHQLKVIDPKLVSPTGAGDMLTQPFMLSFWILVCVGVVGLPHSALRCFGYRDSKALHRGILIGTVVSALLMLGMHLAGALGRAILPGMDSPDKIMPSLMMEVLPPWLAGVFLAAPMAAIMSTIDSQLIQASATLVKDLYLNYLNPRQEKLEVRIPRLSLLCTLILGTLVLLAALQPPEMIIWLNLLAFGGLQAVFLWPLVLGLYWSRANGPGALASMVSGIVCYGALSQWGIKLAGLHAIVPSLGLGLAAFILVSLLTPPPDQSVRRLFDQK
>NZ_CP050994.1|WP_168234510.1|205032_206457_-|PTS-transporter-subunit-EIIC
MPVQNARKILTQSLQRLGYALLLPVSILPLAALLYRLGQPDVLDLAVLSLAGRALFSQMPLIYAVAIAFGLSRQGQGAQALAGAVNFLLLSSALATLQPGLHADMICGLLAGLTTAMVCSWTRNLSLPGWLRPLQEELPGLLLSALASLLLVVPLALLWPLLEQGITLLASDLLTTPFGAFCYGVLNRLLIPLGLHQVLGSLMGLGESNLLALSAAQPLHEGYVAGLYPVIMFGLPGACFAIWLHRQRMRRLPQGGLLLTLALTSALVGITEPIEFLFAFTAPWLFLAHALLTGLSLAICSGLGIQVGSYFSAGLLDLVLSYGSGEHSFWLIPLGILFFVIYALVFSRLLEYAPLSLPSKPIAEDLPQLAAVAPTDPQMLAIQYLKMLGGMDNLQAMSVCLTRLSLRVREMALVDQSRLARLGCLSWIVLNEHQLVLVLGPSAGLIEGQIRMLAERQSVPLGLEPSQAPLSQSL
>NZ_CP050994.1|WP_168234509.1|204159_205032_+|LysR-family-transcriptional-regulator
MNNVELELMGLFATVVEQGSFTGAAEVLGMPKSSVSQKISRLESRLGVRLLQRTTRRLSLTPQGEVYVEHCQSLLALARSANLAMARLRSAPAGRVRITAPEATGTLLLGRILAQFRALYPEVVLELTLSDEQLDLVGEGYDLALRAAPLKDSSLICRRIGQVARHLVAAPGYLASHGTPQQLTELGGHACLVHGALPVWPLQEGGWRPQGACLSNSLLALRELALHEGGIALLPDHVCRDDLSAGRLLKVLPDHPIPPNPFYLIYPSREHLAPALRSLMDFVAERLPFA
>NZ_CP050994.1|WP_168234508.1|203042_204059_-|zinc-binding-alcohol-dehydrogenase-family-protein
MKAIALTHYLPSDHPHCFIETELPDPTPGPRDLLIRVKATSINPVDTKVRAPKAKVEATPRVLGWDAVGEVVAVGSEVTLFKAGDRVWYAGDISRPGSNSALQLVDERIAALAPKTLSDLEAAALPLTAITAWETLFERIGLNRESTGRLLIIGGAGGVGSIAIQLARQLTRMEVIATASRPETRDWCLAMGAHQVVSHHKLQEELAGLGISQLDAIFCTNATEQHWNAMASLIRPFGHICTIAESSEPWDLGLLKAKSVTFSQEFMFTRSLFQTPDMIEQHKLLGRVAALLDQGVLKSTLTRTLPELTPASLAQAHRELEAGRMVGKLVIDMSGFAS
>NZ_CP050994.1|WP_168234507.1|201644_202523_-|50S-ribosomal-protein-L11-methyltransferase
MPWIQIRINATAKTADKVSNMLLGRGAQAVTFMDAQDVPVYEPLPGETPLWGETEVMGLFDAETDPAPTIAFFQQIFGEDVGYKVEQLEDKDWVREWMDHFHPMQFGERLWICPSWRDVPNPDAVNVMLDPGLAFGTGTHPTTALCLQWLDGLDLAGKTVVDFGCGSGILGIAALKLGAARVIGIDIDPQAIQASHDNAERNGVAGQIELYLPADQPQDVEADVVVANILAGPLRELAPLIADHGKPGSLMALSGVLESQAPELETIYGQWFDMDPTAVKEEWCRLSGRKHD
>NZ_CP050994.1|WP_168234506.1|200818_201388_-|sugar-O-acetyltransferase
MTEYEKMIASQPYNCMAPELDVLRRETARRYRRLNLSEDETEQRALLAELVGELAENAFICPPLYCTYGRHIHLGKRSYINMGATLLDNAPIRIGADVMIGPNVQIYTAAHALDADERIQGVETALPVTIEDRVWIGGGAILLPGITIGREAIVGAGAVVTRDVPAGARVVGNPARILPARDKMPVTES
>NZ_CP050994.1|WP_168234505.1|199861_200410_+|NAD(P)H-nitroreductase
MDALSLLLNRHSCGRLTTPAPSGEVLDNILKAGLRAPDHGTLTPWQFILFEGEGRERLGALLADAARARGEDDESIKKCSEAPLRAPLVVAVATRYQAHPKVPRLEQELSAGCALMAMQMAAQAQGFNGIWRSGWFIFDEVINQGLGLAPEDQLVGFLYLGTPMLEARKLRELPVADFVRRF
>NZ_CP050994.1|WP_168234504.1|197690_199718_+|NADPH-dependent-2,4-dienoyl-CoA-reductase
MSLYPTLLTPLDLGFTQLKNRVLMGSMHTGLEEEKGGFDKLAAFYAERARGGVGLIVTGGIAPNLRGRLVPHGSQLSFPWQVAKHKKVTGAVHQEGGKIALQILHAGRYAYHPFSLAPSAIRAPISPFKPRAMSERQIRGTIRDFASTAALAKAAGYDGVEVMGSEGYLINQFICERTNQRSDGWGGSSENRMRFPLEIVRAIRERVGTDFIIIFRLSMLDLVEKGSSLEEVIALGKALEQAGVSLINTGIGWHEARIPTIATSVPRGAFSWVTAELKKHLTVPLITTNRINTPEVAERILAQGEADMVSMARPFLADPEFVIKAAENRADEINTCIACNQACLDHVFKQKRASCLVNPRACFETELTFGRVPQPKKLAVVGAGPAGLAFACYAAERGHQVSLFDQAPTIGGQFNFAKQIPGKEEFHETLRYFARRLEKCGVELYLGQRQSAESLLGGGFDEVILATGIRPRTPNIPGIDHPKVLSYLDVLRDGKPVGQKVAVIGAGGIGFDVAEFLVEKKAEGSADHHRDHWLKEWGIDKSLGERGGLIAPVIDAPERQIWLLQRKESKVGDGLGKTTGWIHRTVLKNRKVQMLSGVQYLRIDDEGLHIQVGEARQCLPVDQVIICAGQEPLRELQAGLQAAGKPVHIIGGADVAAELDAKRAIRQGAELASVI
>NZ_CP050994.1|WP_168234503.1|195420_197265_-|signal-peptide-peptidase-SppA
MSIFKGLGWLFRSLWRLLNFTRLMLVNLLFLIVVLVIAFSLNQSETPSTPIEGALTLNLAGVLVEQRTQTDPTVQLLRQMEKSDDQPSEIVLSDLLWAIKSAGDDDRIKALVIKPQGLQGASLSKLQEVASAIDAFKESGKPVIAMADYYSQGAYLLAAHADHVLLNQSGAVLIEGFGVYQTYFKSALEKLNVTPHVFKVGTYKSFVEPYTRDEMSPESKEANQRWLDQLWQSYVTDVAEQREIEPDAVAPDKDHFLELLRKAGGNAASYALDNGLVDQLATRDEMTQAVIKEVGESEDHGWKGVGLKEYLAAIPEQYPQSGKDEVGLITASGAIMDGIQPAGTIGGDSLSELLAEARRDDLVKAVVLRVDSPGGSAFAAEQIRAELLALKQAGKPVVISMGSYAASGGYWISADADKIFASPTTLTGSIGVFGMFATIDKALSQYGVHTDGVGTTDFVGVGLTRALPEHVGQAIQLSVEDTYQRFVGLVGKGRGLSPEEAEKAAEGRVWTGQDAKELGLVDEFGNLDDALKAAAELANLKSWQVTPIAPEESARDKFLRELFDSSAQALAPHLQSWLPAGLGKALVEMNRSLDPLTRFNDPQGTYAFCPVCVP
>NZ_CP050994.1|WP_025326015.1|209879_210341_-|acetyl-CoA-carboxylase-biotin-carboxyl-carrier-protein
MDIRKIKKLIELVEESGIAELEISEGEESVRISRNFSGQVSVAPQMMMQPAQVQQAAAPVAAAAQAAAPAADAAPSGHLMRSPMVGSFYRSSSPEAKPFVEVGQHVNVGDTLCIVEAMKMMNQIESDKAGVIKAILVENGQAVEFDEPLFIIE
>NZ_CP050994.1|WP_005326561.1|210377_210827_-|type-II-3-dehydroquinate-dehydratase
MSQHHRILLLNGPNLNLLGKREPGIYGSKTLDEIVADLSQYANELGVTLEHLQSNAEHELVGRIHQAMGQVDFIIINPAAFTHTSVALRDALLGVAIPFIEVHLSNVHAREPFRHHSYLSDVAKGVICGLGADGYQFALTAAVHQLRAA
>NZ_CP050994.1|WP_168234512.1|211111_213058_-|acetate--CoA-ligase
MSESKVYPVKAHIGSDALLDKEGYEAMYLASVQNPDAFWGEQGKILDWMTPYTRVKNTSYDPGHVSIKWYEDGLLNVSANCLDRHLAERGDKVAIIWEGDNPAEDRKLTYRELHGEVCKFANVLKAQGVKRGDMVCLYMPMVPEAAIAMLACTRIGAVHSIVFGGFSPEALSGRIIDSGSSIVITADEGLRGGRPIPLKKNVDEALTHPDTRVNKVIVLKRTGGKVAWHDHRDIWWHDAVAAASPDCPPEAMGAEDPLFVLYTSGSTGKPKGVLHTTGGYLVYAALTFKYVFDYHEEDIYWCTADVGWVTGHSYLVYGPLANGATTLMFEGVPNYPATNRMSQVVDKHQVSILYTAPTAIRALMAKGKEAIEGTSRASLRIMGSVGEPINPEAWEWYYRTIGDERCPIVDTWWQTETGGILISPLPGVTALKPGSATRPFFGVQPALVDNLGEPLEGATEGNLVITDSWPGQMRTVFGDHERFEQTYFSTFPGRYFTGDGARRDQDGYYWITGRVDDVLNVSGHRMGTAEIESALVAHPKIAEAAVVGVPHEIKGQGIYAYVTLIAGEEPSRELHKEVKEWVRKEIGAIATPDVIHWAEGLPKTRSGKIMRRILRKIATGETDSLGDISTLADPGVVDKLIREKSEAA
>NZ_CP050994.1|WP_106887645.1|215165_215534_-|hypothetical-protein
MKTALLLIACWLLALIPLDQGLTPLAVLLFHPDRELYGAAQLTGFAGILLTLYLANLGVEVVLRRRFQIAGMLTLLVAWIDFINSSGSESHFLLLYLLALPFHLLGWLVLVRGIQAFGRQKG
>NZ_CP050994.1|WP_106887644.1|215541_216210_-|molecular-chaperone-TorD
MQEFMATSERRAQLYWWFSTLFAAELSDEQIAEYDTYDVRSFLKSLSTLDPMREAVAELNDAIARLLVRTDRQLELAADFAGLFLVDPKQGALPYESLYRGEAKLLMQAPMAEMQARLDRLGINVSDKYKEPADHLAIELDLMGNLIIHAAEATTAAQRESWLGEQEALLHEHLLAWFPRFEAACRAADQFGFYGASARLLGVFLTMDANYLSLVKPAQSAD
>NZ_CP050994.1|WP_168234513.1|216309_218802_-|trimethylamine-N-oxide-reductase-TorA
MINISRRGFLGGLLASGASALIGPSLLGRAVMAAESGDKLVQSGSHWGAFRARVVDGRWVETLPFEHDKHPTEMLKALSEVVYNPSRIRYPMVRLDWLRKGHQSDTSERGQNRFVRVTWSQALDFFYHELERVQKTHGPSALYAGHSGWQSVGKLHSAGAMLGRAMNLHGTYLAKAGDYSTGAAQVILPHVAGAMEVYEQQTSWPLVLEHSKTIVIWGSDPIKNLQVGWLVPDHSVYDYWAQLKEKVAKGEIRVISVDPVKSKTQKYLNCDQITLNPQTDVPLMLGIAHSLYSEKRHDEAFLKNYTTGFDKFLPYLLGTSDGQVKDAEWAAAICGVPAETIRELARAMTSGRTQLIGGWCVQRMHHGEQYAWMLVVLASMIGQIGLPGGGYGFGWHYNGAGTITSSGPIMSGFSSVIPGVKPIHDGDWKGYSKYIPVARFVDCILNPGKQIAFNGQTITYPHMKMAVFCGNNPFHHQQDRNKMVAAWRKLETVVSIDHQWTASCRFADIVLPATTTYERDDIEQWGSHSNAGILAMYKVVEPLFEARDDYDIFADLCRRFGREAEFTGGKSKLEWIQSIYDDARLQGRGIGIRLPRFSQFWHGEGFVTFPAGQSWVRHASFRQEPDLEPLGTPSGLIEIYSKTIADYGYGDCPGHPVWIEPYERSHGGPGSKQYPLHLQSCHPDKRLHSQLCSSDNYRATYTVQGREPVYMNPQDAHSRGLKDGDLVRVFNGRGQVLAGLVVSEDYAPGVVRIQEGAWYGPQEGGKVGTLCTYGDPNVLTADIGSSSLAQATTAHTALVEIEKFRGQAPAVTAFGAPESAKGIDPMFPAL
>NZ_CP050994.1|WP_168234514.1|218829_219993_-|pentaheme-c-type-cytochrome-TorC
MKKLWHFLRTPSRRWSVLALLLAGVGVTLAGTVGLHYGFEKTSSLEFCISCHSMKDTVYPEYKESIHFKNASGVQAVCTDCHQPKDFVGKVARKMEAANDLYQEYIGHSIDTQEKFEDRRLHLAEKVWARMSSQNSKTCKSCHSYDNMDHAKQSPAAALAMKDAAAKNMNCIECHKGIAHELPNMAGGFRATYATLASEAQQAPAGDTLYTLGEKDLYASEQSTDPVGKLLPASRIDVIARSGDRLQVTIEGWREREGKGRVLSEYMGKRVFVATVRDELKANEKVLKQETDSATHIQWEQVQVQAWVDGKGLEPSLKPIWDYAGEMYKSTCNSCHGAPDPAHFTANGWISGLKAMSAYYRLSKEEERTLLKYLQNHAADTGGQGSH
>NZ_CP050994.1|WP_139745181.1|220144_220858_+|two-component-system-response-regulator-TorR
MSYHILVVEDDAVTREKLTGYFEREGYRVTAVENGQEMRAVLAQQEVDLVMLDINLPGEDGLLLTRELRARSTVGIILVTGRSDAVDRIVGLEMGADDYVTKPFELRELLVRVKNLLWRISLAAPATRVAEPLDDAVYFGPWRFDIPRRQLSKDGVPVRLTKAEYEVLVAFVAHPGRVLSRERILTLISHRGDGPSDRTIDVLIRRLRGKMELDPRDPQLFVTVHGEGYLFAGELAP
>NZ_CP050994.1|WP_168234515.1|221997_224829_+|TMAO-reductase-system-sensor-histidine-kinase/response-regulator-TorS
MRIFSGLGGRLLLAFSLMALLTLSASLLGWIGLTHLRQLEQGVQQTLADQERARTLARLSGEIQSASHLLATATSEAEREHQGRLLTLQGQQMQRLLAQLGGEGERQVQEQLHPLSQAIIGNLGQQGWLVGERLTLMAQGDALRARLVAAAGEVAELARSQMENAETVMVAGLGSLYPLQGRAAAAAAIDRLLEQDLDWLEQMTELRHRTLMQQQRIEEIWRGERQDRLQALLRDGQRELAILQLRAGAVTDPARRQGVEQALAVLAQSDKLVQLRSDWLGKGEALRVLASANDALMSSLNQQVDDLVNRARDSLGESQQALSQRLKLLEQALMGIGLLTLVLLMLLMWRMVYGRIVWPLQHAVAGMSRLARGDLAPLDPIVGAGRDELAELGRALQVFRDNAVELGRYQRELESRVVERTRQLSHANLRLNEEVENQRLARAEAEQANRAKSVFLATMSHEIRTPMNGILGGLTLLEDTHLSETQRRYLAAIEHSGESLLEILNDILDYSKIEAGHLEARREPFPLHQLVDELSALFRPKAEARGVALVLEYAPAQPPVVEGDLGKLRQVLGNLLGNAVKFTARGRICLEVSPLPCGGPCAEPCILFVVSDTGPGIPEQEQEAVFEAFRQRKRDMGHQGGTGLGLAISRKLVAAMGGELRLDSRPGEGCRFSFSLPLQRSAAQLPAAAQPLHLGQPRDILLVEDNEINRLVAQGMLVRLGHSVTLAEDGRSALARVTERGFDLALLDINLPDMDGLTLREDLAAISEEVHERPLPAIAISAQMYPEDIRLCLEAGFADFVGKPVRLAALASAIDRQFQGETTQAPPGAREGAVSPPAPQAANPVLDADLALLGSQRIRQLIGLFESQGAALVAALVRCEGEERKGMAHKLKGSALALGLDDFAAQCAALEAGEGDPAGLAGEFDTAVATLKVWQDRQLPTPA
>NZ_CP050994.1|WP_168234516.1|224832_225159_-|hypothetical-protein
MDHLMLFVIVAVFAIFYWVYYTGSRKGACTTSWETLPTRAQYLTAHPEAVDGDIIFCVHCGHHQQLEVGVVHQADYRRQHICPRCKQALYRDEEQEESGGETVGSRPG

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Crispr_ID: NZ_CP050994_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_2

273880-273988

Orphan

Consensus_repeat	Method
GTCACTTGCCTGCGACATTCAAGCCACCGAAACG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_2

>merge|NZ_CP050994|2|273880-273988|CRISPRCasFinder
GTCACTTGCCTGCGACATTCAAGCCACCGAAACGGATGGATGGAGGAGCATAGAACTCCTTGTCATCCCTTGGTTGTCACTTGCCAGCGACATTCAAGCCACCGAAACG

>NZ_CP050994|2|2|273880-273988|CRISPRCasFinder
GTCACTTGCCTGCGACATTCAAGCCACCGAAACG	GATGGATGGAGGAGCATAGAACTCCTTGTCATCCCTTGGTT
GTCACTTGCCAGCGACATTCAAGCCACCGAAACG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_163157531.1\|283151_283655_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|225695
NZ_CP050994.1\|WP_106887606.1\|273353_273731_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319911
NZ_CP050994.1\|WP_163147844.1\|283872_284265_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_025326072.1\|270293_270542_-\|YfhL-family-4Fe-4S-dicluster-ferredoxin	unknown	unknown	gnl\|CDD\|235941
NZ_CP050994.1\|WP_005326662.1\|272360_273287_+\|L,D-transpeptidase-family-protein	unknown	unknown	gnl\|CDD\|182294
NZ_CP050994.1\|WP_163154249.1\|264218_265178_+\|tRNA-pseudouridine(55)-synthase-TruB	unknown	unknown	gnl\|CDD\|235333
NZ_CP050994.1\|WP_168234532.1\|275295_276696_-\|TldD/PmbA-family-protein	unknown	unknown	gnl\|CDD\|223389
NZ_CP050994.1\|WP_163146997.1\|269301_269655_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224470
NZ_CP050994.1\|WP_168234536.1\|285090_285597_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP050994.1\|WP_168234535.1\|281928_283110_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133416
NZ_CP050994.1\|WP_042649628.1\|284442_285042_+\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-E	unknown	unknown	gnl\|CDD\|235074
NZ_CP050994.1\|WP_168234534.1\|280042_281773_+\|single-stranded-DNA-specific-exonuclease-RecJ	unknown	unknown	gnl\|CDD\|182944
NZ_CP050994.1\|WP_005326646.1\|265337_265607_+\|30S-ribosomal-protein-S15	unknown	unknown	gnl\|CDD\|180170
NZ_CP050994.1\|WP_162627203.1\|269814_270207_+\|DUF1090-family-protein	unknown	unknown	gnl\|CDD\|368932
NZ_CP050994.1\|WP_168234533.1\|277707_278619_+\|site-specific-tyrosine-recombinase-XerD	unknown	unknown	gnl\|CDD\|234713
NZ_CP050994.1\|WP_025326077.1\|276990_277509_-\|flavodoxin-FldB	unknown	unknown	gnl\|CDD\|183471
NZ_CP050994.1\|WP_106887607.1\|270543_271905_-\|tRNA-5-hydroxyuridine-modification-protein-YegQ	unknown	unknown	gnl\|CDD\|237969
NZ_CP050994.1\|WP_163147846.1\|279360_280077_+\|thioredoxin-fold-domain-containing-protein	unknown	unknown	gnl\|CDD\|182802
NZ_CP050994.1\|WP_106887611.1\|265787_267929_+\|polyribonucleotide-nucleotidyltransferase	unknown	unknown	gnl\|CDD\|236995
NZ_CP050994.1\|WP_168234530.1\|268080_269298_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340887

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_163157531.1\|283151_283655_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|225695	COG3153, COG3153, Predicted acetyltransferase [General function prediction only].	5.50907e-51
NZ_CP050994.1\|WP_106887606.1\|273353_273731_-\|VOC-family-protein	gnl\|CDD\|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	3.51954e-29
NZ_CP050994.1\|WP_025326072.1\|270293_270542_-\|YfhL-family-4Fe-4S-dicluster-ferredoxin	gnl\|CDD\|235941	PRK07118, PRK07118, Fe-S cluster domain-containing protein.	2.85879e-07
NZ_CP050994.1\|WP_005326662.1\|272360_273287_+\|L,D-transpeptidase-family-protein	gnl\|CDD\|182294	PRK10190, PRK10190, L,D-transpeptidase; Provisional.	1.9553e-145
NZ_CP050994.1\|WP_163154249.1\|264218_265178_+\|tRNA-pseudouridine(55)-synthase-TruB	gnl\|CDD\|235333	PRK05033, truB, tRNA pseudouridine synthase B; Provisional.	0
NZ_CP050994.1\|WP_168234532.1\|275295_276696_-\|TldD/PmbA-family-protein	gnl\|CDD\|223389	COG0312, TldD, Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only].	1.73916e-121
NZ_CP050994.1\|WP_163146997.1\|269301_269655_-\|hypothetical-protein	gnl\|CDD\|224470	COG1553, DsrE, Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism].	5.7151e-41
NZ_CP050994.1\|WP_168234536.1\|285090_285597_-\|N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.01493e-13
NZ_CP050994.1\|WP_168234535.1\|281928_283110_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133416	cd04789, HTH_Cfa, Helix-Turn-Helix DNA binding domain of the Cfa transcription regulator. Putative helix-turn-helix (HTH) MerR-like transcription regulator; the N-terminal domain of Cfa, a cyclopropane fatty acid synthase and other related methyltransferases. Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	6.47899e-44
NZ_CP050994.1\|WP_042649628.1\|284442_285042_+\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-E	gnl\|CDD\|235074	PRK02830, PRK02830, Na(+)-translocating NADH-quinone reductase subunit E; Provisional.	2.56744e-113
NZ_CP050994.1\|WP_168234534.1\|280042_281773_+\|single-stranded-DNA-specific-exonuclease-RecJ	gnl\|CDD\|182944	PRK11070, PRK11070, single-stranded-DNA-specific exonuclease RecJ.	0
NZ_CP050994.1\|WP_005326646.1\|265337_265607_+\|30S-ribosomal-protein-S15	gnl\|CDD\|180170	PRK05626, rpsO, 30S ribosomal protein S15; Reviewed.	1.62223e-53
NZ_CP050994.1\|WP_162627203.1\|269814_270207_+\|DUF1090-family-protein	gnl\|CDD\|368932	pfam06476, DUF1090, Protein of unknown function (DUF1090). This family consists of several bacterial proteins of unknown function and is known as YqjC in E. coli.	4.63972e-27
NZ_CP050994.1\|WP_168234533.1\|277707_278619_+\|site-specific-tyrosine-recombinase-XerD	gnl\|CDD\|234713	PRK00283, xerD, tyrosine recombinase.	7.05361e-179
NZ_CP050994.1\|WP_025326077.1\|276990_277509_-\|flavodoxin-FldB	gnl\|CDD\|183471	PRK12359, PRK12359, flavodoxin FldB; Provisional.	6.62949e-121
NZ_CP050994.1\|WP_106887607.1\|270543_271905_-\|tRNA-5-hydroxyuridine-modification-protein-YegQ	gnl\|CDD\|237969	PRK15452, PRK15452, putative protease; Provisional.	0
NZ_CP050994.1\|WP_163147846.1\|279360_280077_+\|thioredoxin-fold-domain-containing-protein	gnl\|CDD\|182802	PRK10877, PRK10877, protein disulfide isomerase II DsbC; Provisional.	3.19995e-27
NZ_CP050994.1\|WP_106887611.1\|265787_267929_+\|polyribonucleotide-nucleotidyltransferase	gnl\|CDD\|236995	PRK11824, PRK11824, polynucleotide phosphorylase/polyadenylase; Provisional.	0
NZ_CP050994.1\|WP_168234530.1\|268080_269298_+\|MFS-transporter	gnl\|CDD\|340887	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.23061e-67

>NZ_CP050994.1|WP_106887606.1|273353_273731_-|VOC-family-protein
MDNTLVWADIPTRDLDRAMDFYSALLDVQVTPIQEEEMRFAMLRYDGSNAAACLGPMDKYHQPGGAGPLIYLSLGDRLQEAEQLVPRLGGRVLEPLHSIGSGHGSRVIIEDTEGNWLALYAPPAP
>NZ_CP050994.1|WP_005326662.1|272360_273287_+|L,D-transpeptidase-family-protein
MNPLRIAASALFCTLTLVSQQAAAVEYALPAANSRLIGENQEYVVPADNRPLEQIAADFQLGLTNIMEANPGVDPYLPTPGSKLTIPHQLILPNAPREGIVINVAEMRLYYYPKGKNVVQVLPIGIGQLGVNTPENWITKVERKRANPTWTPTENIRRRYAAQGKTLPAVWPAGPDNPMGLHALYIGNLYAIHGTNATFGIGLRVSSGCVRLRADDIKYLFDNVPVGTRVQFVNQPVKTTVEPDGGRYMEVHEPLSRTEEEFNSTASVPLPMTPATTRFIAHMDSDSNVVKQVLEQRTGMPTRLNPEA
>NZ_CP050994.1|WP_106887607.1|270543_271905_-|tRNA-5-hydroxyuridine-modification-protein-YegQ
MFRPELLSPAGTLKNMRYAYAYGADAVYAGQPRYSLRVRNNEFDHENLQLGINEAHALGKQFYVVANIQPHNSKLKTFIRDMRPVVDMKPDALIMSDPGLIMMMREAFPEMPIHLSVQANAVNWATVKFWHQMGLTRAILSRELSLDEIEEIRMQVPEMELEVFVHGALCMAYSGRCLLSGYINKRDPNQGTCTNSCRWEYKVHEGKEDDVGQIVHRQEPIAVRPDNTLGLGKPSDALVLLEESNRPGEYMTAFEDEHGTYIMNSKDLRAVEHVERLTKMGVHSLKIEGRTKSFYYCARTAQVYRKAIDDAVAGRPFDPTLMGTLENLAHRGYTEGFLRRHNHSEYQNYDYGYSVSDTQQFVGEITGRQGDMVEVEVKNKFLVGNSLELMTPQGNVSFNLEQMQNRKGELIDTAPGNGHVVYVPVPKEIDINYGILLRNLGDRQDTRQPHSAA
>NZ_CP050994.1|WP_025326072.1|270293_270542_-|YfhL-family-4Fe-4S-dicluster-ferredoxin
MALLITDKCINCDMCDPECPNQAISLGDKIYEIDPDRCTECVGHYEKPTCISVCPIDCIIWDPAHVETEEQLMDKFVLMHRQ
>NZ_CP050994.1|WP_162627203.1|269814_270207_+|DUF1090-family-protein
MWKIAGIGLLLLAGQAYGSENVGCKARHQAVTEQLSFARAHDNAQQVAGLEQALRNIEAHCTDAGLVEEQQEKVAKQKQEVEERLADLQSARVSGKPDKIAKKQAKLEESQAELLEAQRELEALQKLIKP
>NZ_CP050994.1|WP_163146997.1|269301_269655_-|hypothetical-protein
MKQEIVIIANGAPYGSESLFNALRLGIALNEQEGVILKIFLMSDAVGAALAGQSPAEGYNLRQMLEILLAQGTLIRLCKSCTDARGISSLPLIEGIKIGTLPLLAQWTLAADKVLTF
>NZ_CP050994.1|WP_168234530.1|268080_269298_+|MFS-transporter
MSWAYLRQFPPLVWIVILGTFMVRTTFFMVWPFLSILLYRDYGLSATLIGLILGATAALSTLVSFYGGWLSDKWGRRNILLFGCLVSALSVALLGLSHQVIWLAMGVIGSGLSYGLIDSPGKALMADSLAEPKARELALHLRYFLLNLGAAIGPLLGVSYGLSARQETFLLLSVSYLVLGFIFFIGFRLAACQASHAAGPGMRVVLRVLWQDRGFLLLTLANVLLMLVYVQFESPLIQYLTRAGTPEVERLIGWLVSTNALTIVILQFPLLHLTARWPTKRRLQLGVALFLGAQLLFALGNTAIWWHWIVAVILLSVGECILFPLLNVLIDQMAPSHLKGSYFGAASMSGLGVAIGALLGGWILSNWGGGLLYALMALLCLVILMLYGLSTRIPRPALARVGAGS
>NZ_CP050994.1|WP_106887611.1|265787_267929_+|polyribonucleotide-nucleotidyltransferase
MNPIVKSFQYGQHTVTLETGVMARQATAAVMVSMDDTCVFVTVVGKKEADHGRDFFPLTVNYQERTYAAGRIPGGFFRREGRPSEGETLISRLIDRPIRPLFPEGFLNEVQVVATVMSVNPAVSPDIVAMIGASAALAISGIPFGGPIAAARVGYMNGQYVLNPTTTELPQSDLDLVVAGTANAVLMVESEAAILSEEVMLGAVVYGHEQMQVVINAINEFAADVGTQPWDWTPPAVNEALKAKVAELATAELGEAYRITEKAVRYAAIGAIKSRVVEQVIASGVEEDAKKIGEEFHSLESRIVRGRVVRGEPRIDGRDPEMIRALSVGTGILPRAHGSALFTRGETQAIVVATLGTERDAQNIDELAGHRADRFMLHYNFPPYCVGETGMMGSPKRREIGHGRLAKRGVAAVMPSAAEFPYVVRVVSEITESNGSSSMASVCGSSLALMDAGVPIKASVAGIAMGLVKEEEGFVVLSDILGDEDHLGDMDFKVAGTTQGITALQMDIKIEGITKEIMEIALKQARGARLHILKVMDEAIQAPRAEISDFAPRIHTIKINPEKIKDVIGKGGSVIRALTEETGTNIELDDDGTVRISAVANEAAMEAIRRIEAITAEIEVNRIYEGKVVRLADFGAFVNILPGKDGLVHISQITDARVQNVADFLKIGDVVKVKVLEVDRQGRVRLSIKEANAPTEAAAPVADVAVAEEPAAE
>NZ_CP050994.1|WP_005326646.1|265337_265607_+|30S-ribosomal-protein-S15
MSLNAEIKASIVADNARCANDTGSPEVQVALLTAQINHLQGHFKEHSKDHHGRRGLLRMVSQRRKLLDYLKRKDVQRYAALIAKLGLRR
>NZ_CP050994.1|WP_163154249.1|264218_265178_+|tRNA-pseudouridine(55)-synthase-TruB
MSRRRRFKGRDVHGILLLDKPTGLTSNDVLQKVKRIYNAAKAGHTGALDPLATGMLPICLGEATKFSQYLLEADKRYEVTAKLGERTNTSDSDGEVVSTRPVNVAVGTLIEALDQFRGPIMQVPSMYSALKHNGRPLYEYAREGIEIEREARPITVFELKLLSFEGDEVRLEVHCSKGTYIRSLVDDLGEVLGCGAHVTQLRRTQVASYPYDRMLTLDQLECIFEQAKAESIPPREQLDPLLLPMDTAVASLPEVNMLTAVAAYVNQGQAVQVAGAPQSGQVRMTVGPEREFIGVGEIDDEGRVAPKRLVRYHDDNNEE
>NZ_CP050994.1|WP_168234532.1|275295_276696_-|TldD/PmbA-family-protein
MTSFSLLAPTIARDVLDHALRLGADFAELFVERKRRSQLSLLSSQIENISGGLDFGIGVRLCYGHKVLYGYTNLASRDELLRIVSLLAAKDRRDPVVTATAFDFTPITDRNPVALPLSADKQLEQKIAYLHAMDAVARAESGKVSQFSGNVLGWEQEVEIFNSEGLQVSDRRHYNRIMAQTIAVEGSEQSVGYEAPGALMGWEHAERIDPRELALTATRQALVKLGAAPCPSGTLPVIMESGFGGVIFHEACGHLLETTSVAKKASVFHDKMGQLIANPAVSAVDEGLQSNAWGSINVDDEGMATQHTQLIKDGVLTGFLVDRMGAIKTGHARTGSGRRESYKFAPTSRMRNTYIEPGSHSLDDMLATVEHGIYAKKMGGGSVQPGTGEFNFNVQEAYLIEHGKITRPLKSATLIGTGPQVLKEISMVGRNLALAAGMCGSVSGSVPTSVGQPALKVDKILVGGNA
>NZ_CP050994.1|WP_025326077.1|276990_277509_-|flavodoxin-FldB
MKIGLFYGSTTCYTEMAAEKIRALIGPELVDLHNIKDVPLARMQEYDILILGISTWDFGELQEDWESRWEDIKDVPLEGRIIALFGMGDQLGYGEWYQDALGLLHDQLVPKGVRLVGYWPNEGYEFDASKALIDDGRHFVGLALDDANQYDQTESRIEQWVDQILNEIHELL
>NZ_CP050994.1|WP_168234533.1|277707_278619_+|site-specific-tyrosine-recombinase-XerD
MTKPAPAVHNHPLIEPFLDALWLERGLSDNTVSSYRTDLEKFALWLDGQGGSLLLAGMDDIQHYLAWRVDKQFAASSTARFLSALRRFYQYLNREKLRGDDPTVLLEGPKLPKKLPSDLSEAEVDALLTAPQVDDPLELRDKAMLELLYATGLRVSELVGLTAEHVSLRQGLVRVVGKGNKERLVPMGEEAVHWLERYYREARTLLLGGTSSDVVFPSKQARMMTRQTFWHRIKLYAQRAGIRGELSPHTLRHAFATHLLNHGADLRVVQMLLGHADLSTTQIYTHVANERLKALHGEHHPRA
>NZ_CP050994.1|WP_163147846.1|279360_280077_+|thioredoxin-fold-domain-containing-protein
MRHLLLGMMLLCTFAASAGMDPQLLKQTIGQRLGVQVFLVDETPVPGLYLLGTAQGLLYSDARGNYVLQGSMLDLAHDMQNLTRLSQQQQRRLALAQVGEARLWLKAPNERYRVTLFTDLGCRRCHAVLDDLPQLQARGVSVQLLPLVAPFAELAETQALWCDPALLGELSLSDRLPAAGCNEILAHHIGLSQWLGIKASPSWVLPNGDLVRGYQSPEQLLKILDHINAPANPSSSAS
>NZ_CP050994.1|WP_168234534.1|280042_281773_+|single-stranded-DNA-specific-exonuclease-RecJ
MPLQIRRRPRVDDSHLPATLHPLLRQIFASRGVEDPALLERSASQLLPPQRLFGMEQAVPLLADALTAQQRILIVGDFDCDGATSSALCVLALRAMGGHHVDFLVPNRFEFGYGLTPEIVELAVARGAEFLITVDNGISSIAGVAAAKAAGMRVLVTDHHLPGQELPDADAIVNPNQRGCDFPSKSLAGVGVAFYLMAALNTHLRQSGWYERQGIRAPNVADYLDLVALGTVADVVALDGNNRILVHQGLQRIRAGRCRPGIQALVDVSGRDGRRLCAADLGFALGPRLNAVGRLDDMSLGVACLLSDDLNLARQLAAEMDSLNQERKEIEQGMQQEALATLEQIRFRDGEVPSGIVLHRDEWHQGVVGLVASKIKEKYYRPVIAFAQSSDTELKGSGRSIPGVHLRDALELLDTRHPGLMGKFGGHAMAAGLTLPKANIEAFGRAFEAVIAELVNPELLTGVLLTDGELLPDELSLELAELIRASGPWGQAFPEPLFDGEFVLVQQRLVGEKHLKLMLTTDSGHAVDAIAFGVDLKRWPDASVKRVRLVYRLDVNEWRGNRSVQLLVEHLEAAGL
>NZ_CP050994.1|WP_168234535.1|281928_283110_+|MerR-family-transcriptional-regulator
MKISELAQRCGLARSTLLYYEKLGIIEGKRAANGYRHYDEGDLQRLQMVQALQAGGLSLKQCLACLAGDIDQGALQARVKELDDELVRMQRARDLLADLAGMSTHSGDAFKDWQLQLQREAPEAYFEWVMKQGFGEKDRYHLQWLSKDMNEHQSYIRDFKQLLYGMSHWGPGDRAFTQQQFAALPIQPRRILDMGCGRGASTLALAQVTNAAIVAIDLDEEALAALARSASAAGYDKVTTLRANMAALPADLAPADLIWAEGSAYVMGVAKALNAWRSLLAGPDACIVLSDAVWLTDVPPEEAQAFWQQAYPAMQTLAGLLETVRAAGYRCLSHTLLPMGAWNNYLDPIERNLARHSAELGESTAYQDLTRELAMHRQYLGSYGYVICCLQLT
>NZ_CP050994.1|WP_163157531.1|283151_283655_+|GNAT-family-N-acetyltransferase
MNILIRPETSADHDAIEQLTIAAFLTAPHTDHNEQLIVCDLRKAGALSLSLVAELEGKVVGHLCFSPVSITDGSEKWFGLGPISVSPEMQGKRVGSRLMKAGLAALEANGAAGCVVLGDPGFYSRFGFVADAHLVLPGVPAEYFMVRRFDDERARGEVSYHAAFTQG
>NZ_CP050994.1|WP_163147844.1|283872_284265_+|hypothetical-protein
MALAVACLLWLAVSAAAGLSAPALSDQGTSTSSMQLHEPPAPGLADNLSLPPASQWRLSFEQGRRLEGARDPDLYQMLLAWFQHEILGLLCGLLFFLPLIYLRQWPNCLGHLHQRQLLCHHLQFRFCHGD
>NZ_CP050994.1|WP_042649628.1|284442_285042_+|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-E
MDYYVNLFIQSIFVENLALAFFLGMCTFLAVSKNINTAFGLGMTVLVVMVIAIPLNNLIYRHILRPDSTFLGEFDLSFLDFIIYIGVLAALVQVMEMVLDKHFPALHQALGIYLPLLTVHCAIFGGVMFMAQRDYDFIESVVYGAGSGLGWLLAIVAIAGLRQKMKYSDVPEGLRGIGITFIVAGLMSLGFMSFSGISL
>NZ_CP050994.1|WP_168234536.1|285090_285597_-|N-acetyltransferase
MPTPIVRLIPMDEAAFPAYRDYFIDDYAQDLASNHGLTLADARQQAEASLLQHLPQGAATPGQSLLCIIPVSDNVGSAVATTAGIAGYLWHSIDSAAHTTFIYDFYTLPTHRGLGYGKAAMAVLEADLKCLGVSQIKLRVAYDNPRARALYEEIGFHITGYNMAKTLA

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Crispr_ID: NZ_CP050994_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_3

304352-304518

Orphan

Consensus_repeat	Method
TCGTCGTCGAGGTAGGGATCCGCAAAGCCGAGCTCCTGCATGATGTCGCGCTCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_3

>merge|NZ_CP050994|3|304352-304518|CRISPRCasFinder
TCGTCGTCGAGGTAGGGATCCGCAAAGCCGAGCTCCTGCATGATGTCGCGCTCGACTCTTGAACCGCACCATCTCCTCGGCTTCTCATTCACCTTATCCTTATCCTTCGACTTCGTCGTCGAGGTAGGGATCCGCAAAGCCGAGCTCCTGCATGATGTCGCGCTCGA

>NZ_CP050994|3|3|304352-304518|CRISPRCasFinder
TCGTCGTCGAGGTAGGGATCCGCAAAGCCGAGCTCCTGCATGATGTCGCGCTCGA	CTCTTGAACCGCACCATCTCCTCGGCTTCTCATTCACCTTATCCTTATCCTTCGACT
TCGTCGTCGAGGTAGGGATCCGCAAAGCCGAGCTCCTGCATGATGTCGCGCTCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_168234544.1\|308881_309460_+\|cysteine-hydrolase	unknown	unknown	gnl\|CDD\|238245
NZ_CP050994.1\|WP_168234539.1\|295780_296434_-\|nicotinate-nucleotide-adenylyltransferase	unknown	unknown	gnl\|CDD\|234611
NZ_CP050994.1\|WP_025326108.1\|310562_310787_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_163157494.1\|296498_297533_-\|DNA-polymerase-III-subunit-delta	unknown	unknown	gnl\|CDD\|235511
NZ_CP050994.1\|WP_168234547.1\|312379_313927_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_CP050994.1\|WP_168234548.1\|314171_314666_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377558
NZ_CP050994.1\|WP_168234541.1\|301629_303159_-\|apolipoprotein-N-acyltransferase	unknown	unknown	gnl\|CDD\|234721
NZ_CP050994.1\|WP_005329815.1\|294757_295225_-\|23S-rRNA-(pseudouridine(1915)-N(3))-methyltransferase-RlmH	unknown	unknown	gnl\|CDD\|129349
NZ_CP050994.1\|WP_163157492.1\|297668_298151_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225527
NZ_CP050994.1\|WP_111910358.1\|311495_312098_-\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|226090
NZ_CP050994.1\|WP_106887585.1\|306025_307459_-\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	unknown	unknown	gnl\|CDD\|237673
NZ_CP050994.1\|WP_168234540.1\|298270_300847_-\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234743
NZ_CP050994.1\|WP_111910428.1\|301081_301564_+\|zinc-ribbon-containing-protein	unknown	unknown	gnl\|CDD\|182915
NZ_CP050994.1\|WP_163157498.1\|295231_295567_-\|ribosome-silencing-factor	unknown	unknown	gnl\|CDD\|272901
NZ_CP050994.1\|WP_168234545.1\|309558_310449_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176106
NZ_CP050994.1\|WP_168234546.1\|310783_311503_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|319829
NZ_CP050994.1\|WP_168234542.1\|304917_305976_-\|PhoH-family-protein	unknown	unknown	gnl\|CDD\|224616
NZ_CP050994.1\|WP_106887593.1\|292727_294656_-\|penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|274573
NZ_CP050994.1\|WP_005329827.1\|303357_304239_-\|CNNM-family-magnesium/cobalt-transport-protein-CorC	unknown	unknown	gnl\|CDD\|226910
NZ_CP050994.1\|WP_168234543.1\|307684_308848_+\|NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|181564

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_168234544.1\|308881_309460_+\|cysteine-hydrolase	gnl\|CDD\|238245	cd00431, cysteine_hydrolases, Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.	3.54239e-40
NZ_CP050994.1\|WP_168234539.1\|295780_296434_-\|nicotinate-nucleotide-adenylyltransferase	gnl\|CDD\|234611	PRK00071, nadD, nicotinate-nucleotide adenylyltransferase.	8.5156e-78
NZ_CP050994.1\|WP_111910358.1\|311495_312098_-\|nitroreductase-family-protein	gnl\|CDD\|226090	COG3560, FMR2, Predicted oxidoreductase related to nitroreductase [General function prediction only].	1.15532e-111
NZ_CP050994.1\|WP_163157494.1\|296498_297533_-\|DNA-polymerase-III-subunit-delta	gnl\|CDD\|235511	PRK05574, holA, DNA polymerase III subunit delta; Reviewed.	2.15181e-104
NZ_CP050994.1\|WP_168234547.1\|312379_313927_+\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	3.02019e-42
NZ_CP050994.1\|WP_168234548.1\|314171_314666_+\|hypothetical-protein	gnl\|CDD\|377558	pfam05818, TraT, Enterobacterial TraT complement resistance protein. The traT gene is one of the F factor transfer genes and encodes an outer membrane protein which is involved in interactions between an Escherichia coli and its surroundings.	0.00109702
NZ_CP050994.1\|WP_168234541.1\|301629_303159_-\|apolipoprotein-N-acyltransferase	gnl\|CDD\|234721	PRK00302, lnt, apolipoprotein N-acyltransferase; Reviewed.	0
NZ_CP050994.1\|WP_005329815.1\|294757_295225_-\|23S-rRNA-(pseudouridine(1915)-N(3))-methyltransferase-RlmH	gnl\|CDD\|129349	TIGR00246, Ribosomal_RNA_large_subunit_methyltransferase_H, rRNA large subunit m3Psi methyltransferase RlmH. This protein, in the SPOUT methyltransferase family, previously designated YbeA in E. coli, was shown to be responsible for a further modification, a methylation, to a pseudouridine base in ribosomal large subunit RNA. [Protein synthesis, tRNA and rRNA base modification].	4.50094e-91
NZ_CP050994.1\|WP_163157492.1\|297668_298151_-\|hypothetical-protein	gnl\|CDD\|225527	COG2980, RlpB, Rare lipoprotein B [Cell envelope biogenesis, outer membrane].	2.30285e-30
NZ_CP050994.1\|WP_106887585.1\|306025_307459_-\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	gnl\|CDD\|237673	PRK14325, PRK14325, (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional.	0
NZ_CP050994.1\|WP_168234540.1\|298270_300847_-\|leucine--tRNA-ligase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0
NZ_CP050994.1\|WP_111910428.1\|301081_301564_+\|zinc-ribbon-containing-protein	gnl\|CDD\|182915	PRK11032, PRK11032, zinc ribbon-containing protein.	1.04439e-52
NZ_CP050994.1\|WP_163157498.1\|295231_295567_-\|ribosome-silencing-factor	gnl\|CDD\|272901	TIGR00090, rsfS_iojap_ybeB, ribosome silencing factor RsfS/YbeB/iojap. This model describes a widely distributed family of bacterial proteins related to iojap from plants. It includes RsfS(YbeB) from E. coli. The gene iojap is a pattern-striping gene in maize, reflecting a chloroplast development defect in some cells. The conserved function of this protein is to silence ribosomes by binding the ribosomal large subunit and impairing joining with the small subunit in response to nutrient stress. Note that RsfS (starvation) is an author-endorsed change from the published symbol RsfA, which conflicted with previously published gene symbols. [Protein synthesis, Translation factors].	4.1438e-51
NZ_CP050994.1\|WP_168234545.1\|309558_310449_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176106	cd08414, PBP2_LTTR_aromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LTTRs involved in degradation of aromatic compounds, such as CbnR, BenM, CatM, ClcR and TfdR, as well as that of other transcriptional regulators clustered together in phylogenetic trees, including XapR, HcaR, MprR, IlvR, BudR, AlsR, LysR, and OccR. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	6.5036e-43
NZ_CP050994.1\|WP_168234546.1\|310783_311503_+\|HAD-IA-family-hydrolase	gnl\|CDD\|319829	cd07527, HAD_ScGPP-like, subfamily of beta-phosphoglucomutase-like family, similar to Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p). This subfamily includes Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p). GPP1p and GPP2p are involved in glycerol biosynthesis, GPP1 is induced in response to both anaerobic and hyperosmotic stress, GPP2 is induced in response to hyperosmotic or oxidative stress, and during diauxic shift; overexpression of DOG1 or DOG2 confers 2-deoxyglucose resistance. These belong to the beta-phosphoglucomutase-like family whose other members include Lactococcus lactis beta-PGM, a mutase which catalyzes the interconversion of beta-D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), and Escherichia coli 6-phosphogluconate phosphatase YieH. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.77098e-61
NZ_CP050994.1\|WP_168234542.1\|304917_305976_-\|PhoH-family-protein	gnl\|CDD\|224616	COG1702, PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms].	1.64775e-165
NZ_CP050994.1\|WP_106887593.1\|292727_294656_-\|penicillin-binding-protein-2	gnl\|CDD\|274573	TIGR03423, pbp2_mrdA, penicillin-binding protein 2. Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NZ_CP050994.1\|WP_005329827.1\|303357_304239_-\|CNNM-family-magnesium/cobalt-transport-protein-CorC	gnl\|CDD\|226910	COG4535, CorC, Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism].	3.32693e-145
NZ_CP050994.1\|WP_168234543.1\|307684_308848_+\|NAD(P)-binding-protein	gnl\|CDD\|181564	PRK08849, PRK08849, 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional.	0

>NZ_CP050994.1|WP_005329827.1|303357_304239_-|CNNM-family-magnesium/cobalt-transport-protein-CorC
MTDDHPSTGSPKKTWLDKLSQLFQGEPKDRNDLVEVIADAEERDLIDQDTKDMIEGVLEIAELRVRDIMIPRSQMVTIEKSQPVDDFLPVIIESGHSRFPVINEDKDHVEGILLAKDLLPFGFGGHHASEPLQLEKILRPTVIVPESKRVDRLLKEFREERYHMAIVVDEFGGVSGLVTIEDILELIVGEIDDEFDDIEDEPEEIRRISKRVFSVSALTEIEDFNDFFGTQFSDEEVDTVGGLVMHAFSHLPKKGEEIELDGYLFKVMHADRRRLQQLQVKIPENHAAAQPES
>NZ_CP050994.1|WP_168234541.1|301629_303159_-|apolipoprotein-N-acyltransferase
MKSKLLTSLFALASGAIAVLAFSPFGYWPLVILSLLGLYALLDKANPKQAAWRGFGYAMGLFLPGQWWIHVSMTEFGGIPLPAAFVLLAGLCAYLSLYPTLACWAFARFFGGRHWSRWLLAFPALWLMADWLRGWVMTGYPWLWFGYTQIDGPLKGFAPILGVQGITLALLLTTSALWLTWQSRKPAWLLLPVVLVGAAQGLMQLNWVTRGEPVKVALVQGNIAQSLKWDPEALIPTVRTYQDLSRENQDADIIIWPESAIPAIEKEMGTYLESLDKAMKVNDTGLLAGIIHYDLKQQRFYNTVLGMGVQDLDGKESYHYEHKNRYYKYHLLPIGEFVPFEDLLRPIAPFFNLPMSSFSRGDEVQPNLIAKGLKFAAAICYEIIFPDEVRRNVQPDTDFLLTVSNDAWFGTSIGPWQHMEIARMRALELARPLLRDTNTGITIVTEIDGSIIGQIPQFEAGVLRAEVRPAHGSTPYLRFGSWPMYALAALLLGLALVLRPRAHPWARQR
>NZ_CP050994.1|WP_111910428.1|301081_301564_+|zinc-ribbon-containing-protein
MDKRRQGYEAFIAQLKKQWEETEEFQGERLNRMIAKVQAYLEAAGDLTQDELALIAEYVKRDLGNYDESRAEVPESAFMLALKDTVWSWLADVTDRAQVEWSELADELEHKGVYRAGDWVGLGVLVCDHCEWRHTVLHPEQLGTCPECGANEYHREPLSP
>NZ_CP050994.1|WP_168234540.1|298270_300847_-|leucine--tRNA-ligase
MQEQYVPQSIEPAVQKHWDAKKTFKAVEKVDKEKFYCLSMFPYPSGRLHMGHVRNYTIGDVISRYQRLNGKNVLQPIGWDAFGLPAENAAIKNATAPAPWTYENIEYMKNQLKMLGLGYDWDRELATCKPDYYRWEQWFFTKLYEKGLVYKKTSSVNWCPNDMTVLANEQVIDNCCWRCDTPVEQKEIPQWFIKITDYAEELLNDIDNLEGWPEMVKTMQRNWIGRSEGVNISFNIDGQDEQLEVYTTRPDTFMGVTYVGIAAGHPLAAQAAASNPELAAFIEECKHTKVAEADMATMEKKGMATGLYAIHPLNGRKVPVWVANFVLMNYGTGAVMAVPGHDQRDFEFATKYGLDIKAVIKPADGEVDVSEAAYTEKGVLFNSGEFDGLDFQGAFDAIANKLEALGHGKRTVNFRLRDWGVSRQRYWGAPIPMLTLADGTVVPTPEDQLPVLLPEDVVMDGIQSPIKADPEWAKTTYNGQEAFRETDTFDTFMESSWYYARYCSPDYDKGMLDPAAANHWLPVDQYIGGIEHACMHLLYARFFHKLLRDTGLVNSDEPFKRLLCQGMVLADAFYYKDEKGGNVWVSPTDVKVERDDKGRITKAVDLEGREVIHSGMTKMSKSKNNGIDPQLMVERYGADTVRLFMMFASPADMTLEWSDSGVEGAQRFLRRLWRTTFEHVSGGAVAALDVAALSNEQKAVRRELHKTIAKVSDDVGRRQTFNTAIAAIMELMNNLAKLGSDEQDRALMQEALEAVVVMLYPITPHIGFELWKMLGKEGDIDVAAWPVADEAAMVETEKLVVVQINGKMRGKLTVPAEISQADVEKLAMADASVQKFTEGLTVRKVVYVPGKLLNIVAN
>NZ_CP050994.1|WP_163157492.1|297668_298151_-|hypothetical-protein
MGMPLTRWIAIMLTGLLLQACGFQMRGTAIPPELMTMKVVGDNKSDFYRLVTTRLKASGVTLADKEGIPVLTLSGVSSSSQVASVDSIGQDREYLLGYSTQFTVSMPGKPTQVFPITFNRSFLNKPDAALASSREQEQLGKEMQEQAANLVIRQLSQVKF
>NZ_CP050994.1|WP_163157494.1|296498_297533_-|DNA-polymerase-III-subunit-delta
MRIYPEQFADHLKAGLKPCYLVFGDEPLLKLEAIDAVRQVARKQGFDERHSFVVEAGLDWNQVYDACQAMSLFSARQIIELELPAKVDKDLAARITEIGKQLHPDLLLVLSGGRLNQTQMKAAWFDKLSQSGTYVPVNHPEPRFFPRWMSARFQRFGLKALPDAVNFMCHAFEGNLLAASQEIEKLTLLGPPQPISVAYLQETIIRHAHFTPFQLVDTLLEGKVNRAQRILLALRAEGTEPGMLAWTLCRELEQLTELALAARAGQPLVEHFSRLRIWQSRQQLIQQALTRLPVGKIQQLWQLMARLDDAQRRFDTEQAWLMLQTIALGFRDGTPLPLLEAEPC
>NZ_CP050994.1|WP_168234539.1|295780_296434_-|nicotinate-nucleotide-adenylyltransferase
MLKAPIGILGGTFDPIHIGHLRPAIEARDALGLAEVRLLPNHIPPHRANPFCSSEQRLAMVALAAAENPGFVVDERELQRDTPSWTIDTLIELKQELPDTPVCFLMGMDSLLGLPGWHRWQELLEHAHLVVSKRPGWQPDYPGEVASLLARHQTRDVQDLHRHRQGHVWIADNLPIELSATRLRALLAAGQDPRYLLPAPVADYIRRHRLYQPSPSR
>NZ_CP050994.1|WP_163157498.1|295231_295567_-|ribosome-silencing-factor
MQGQELLAFIVDKIDDMKGRDIITLDVRGKSSITDTMIICSGNSSRHVSSIAHHLASEARHAGIALLSVEGQLTGEWVLVDMGSVIVHVMQDEYRDFYQLEKLWGGTQVQA
>NZ_CP050994.1|WP_005329815.1|294757_295225_-|23S-rRNA-(pseudouridine(1915)-N(3))-methyltransferase-RlmH
MKIQLIAVGTKMPAWVEHGFEEYRRRFPKDMPFELVEIGAGKRGKNADIPRILQKEGEAMLAAAGRSRIVTLDIPGKPWTTEQLAVSLEAWKLDGRDVALLVGGPEGLSPECKAAAEQSWSLSPLTLPHPLVRVLVAESLYRAWSITTNHPYHRE
>NZ_CP050994.1|WP_106887593.1|292727_294656_-|penicillin-binding-protein-2
MLKNRIEMRDHSAEGRLFFRRTLVAYIGMVVLMLVLLGNLYYLQVESYETYQTRSNDNRIRVVPVAPPRGLIYDANGVLLAENRPVYSLEIVPEETEDLEKTADELITLLALPEGTKERFLAEVKRQRRFKPVPLFEKLTEYQVALFSVNQHNYPGASIEAYLKRYYPFGDTLTHALGYVAKINTRDVERLDKEDKLANYAATKDIGKQGVEKFYEDQLHGVAGYQEVEVNNRGRVVRTLKFQPPEPGKDIYLNIDIRLQLKAQELLAGRRGAIVMMDPNTGAILAMESSPSYDPNLFVTGISNTNYSALLNDPARPLVNRTTQGIYAPASTVKPMMAVMGLNEGAITPNYRYFGGPSFSIPGTTKKFRDWRRWGHGWLDVYRAIEVSADTYFYDLAYRVGIDKIHAYMTKFGFGQYSGVDLYEETKGVMPSRDWKMARWRQPWYQGDTISIGIGQGYWSSTPIQLAKAISILTQNGHDVTPHLLKSTASVDGVVNAPINPNVAIAAKSDTYWQVAKDGMWRVINGHEGTGRRAFAGTPYKAAGKSGTAQVVGLKENQVYNAATTKVEHRDNALFVAFAPFEAPKAVVALVLENAGGGSAMGAPVARHMLDAYLLPPEPQLPPAPDKPSTPGPDQREAVPNE
>NZ_CP050994.1|WP_168234542.1|304917_305976_-|PhoH-family-protein
MSRHISTLNLHLEPADNLRLASLCGPFDDNLKQLERRLGIEISYRDNHFQLLGKQAQIDAAAVILKHLYVETQPLKGGKVTDITPEMVHLTVQESRVLEQDDDEAPSQPYGKEVTVKTKRGLIKPRSPNQAQYISNIVRHDISFGIGPAGTGKTYLAVAAAVDALERQEIRRILLTRPAVEAGEKLGFLPGDLSQKVDPYLRPLYDALFEMLGFERVEKLMERNIIEVAPLAYMRGRTLNDAFIILDEAQNTTTEQMKMFLTRIGFNSKAVVTGDITQVDLPRSTKSGLRHALEVLQGVDGLSFNFFESKDVVRHPVVARIVQAYEAFDAQQAAEKSAPNTRNENTSKESAQ
>NZ_CP050994.1|WP_106887585.1|306025_307459_-|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB
MSKKLHIKTWGCQMNEYDSSKMADLLDASNGYTLTEEPEEADVLLLNTCSIREKAQEKVFHQLGRWKKLKLKKPGLVIGVGGCVASQEGEALRQRAPYVDIVFGPQTLHRLPAMIKQVQEGRGAQVDIAFPEIEKFDNLPEPRAEGVTAFVSIMEGCSKYCSFCVVPYTRGEEVSRPLDDVLYEIAQLAQQGVREVNLLGQNVNAYRGPTFDGNDCTFAELLRLVAAIDGIDRIRYTTSHPIEFTDDIIEVYKDTPEVVSFLHLPVQSGSDRILTMMKRPHTVLEYKSKIRRLRAARPDITMSSDFIVGFPNETDEDFEATMKLIEEINFDMSFSFIYSPRPGTPAADLPDDVDMEVKKARLTRLQNQINHQSMLIGRAMLGSVQRILVEGPSKMDPMQLSGRTENNRVVNFEGPHRLIGGFADVEITDVRPYSLRGRFIRGEDEMNLRIATAPSEILARRPDNVPDDLGVAAFRPH
>NZ_CP050994.1|WP_168234543.1|307684_308848_+|NAD(P)-binding-protein
MEQCDIAIVGAGMVGAATACLLAAEGLNVRVIETRLPEHYAPDQPLDLRVSAISQASVALLDKAGAWSHLQQMRLCPYRRLETWELDGFATRFDSADLGLPQLGYIIENRLVQLALLRRMEDFPNIQTHTPAAVKSLRQSADEAVLTLDDGTELQARWVLACDGAESLTRRLAGIGVSRFEYRQHCMLINIDTEFEQEDITWQQFTPSGPRAFLPLPGRHGSLVWYDSPARIRALAAMGNEALAAEVRRHFPARLGGFQVTGKGSFPLVRRHANHYHAGRVVLLGDAAHTINPLAGQGVNLGFKDVACWAELLGKAGADWHDITLASRYERRRRPDNLLMQSGMDLFYGVFSNDIGPLRLTRNLALTLADKAGPLKEMALRYALGLV
>NZ_CP050994.1|WP_168234544.1|308881_309460_+|cysteine-hydrolase
MNKALLVIDFINDIAHPDGRIAASAAHVQEQDAITHANQALAHARARGWLVVLIKVGFDGGYLLQPKGSPMFGRAHQQGALSLADSGTDFHPELDVAPGDLVLTKPRVSPFYGTALEPALRANHIDHLYLCGVSTGWAIQAAARDGHDRDYAITILEDACAAADANEHHASLRQLGRIAEVIKVAKLLSDPG
>NZ_CP050994.1|WP_168234545.1|309558_310449_-|LysR-family-transcriptional-regulator
MKLDLRQLQAFVMLAETANYREAASRLFITQPALTKQIQGLELALGSTLFNRGRHGAELTAIGTQLLPQARALVEHGKGFEHHALALASGAAGRLKIGFGLSSFALAPSLVARFKQQAPDVMVHLQDMTSAVQHDLLLAGRLQIGFMRRPEAPQLREHRLLTDRLVLAVPSQMTGPDPAAFDVERALTTQPLLQMVGHRCPGLSQQIARFLGANRLTGMIQEAEDIQTLVALVAAGIGNAILPRSVGFIAGKDVTLYPLSGPWSEWEISLVWNPDFADPIRDRFLTLVRAMHPEAE
>NZ_CP050994.1|WP_025326108.1|310562_310787_+|hypothetical-protein
MSSERYLFLIKGSLVMAQPLAAPETGELLTSLLQQGFAVGPLPVWASNTEQALACYEQSAQRQAFVDVLAGRTA
>NZ_CP050994.1|WP_168234546.1|310783_311503_+|HAD-IA-family-hydrolase
MTMLTLRAEALLLDMDGTLVHSTTEVETVWRLWCQGHRLDPAPVLAMCHGVRSREVIRALAPQLDLAREVALLDELEIQHAGVAEPIAGARTLLAALAPDRWALVTSASLRVARHRLASAGLPLPKLLIGAEEVERGKPDPEPYLLAARWLGLAPADCLVFEDAPAGILSALQAGCPVVQIGGGRRLDPAVVAVIPDWRQVTVVAKEAGPLLVTLPTREAGNKKPPASEGLSGRDPGTI
>NZ_CP050994.1|WP_111910358.1|311495_312098_-|nitroreductase-family-protein
MSSPFIEQIKVRRTIYALGDQVTHSEAQLTALIKDAIKHSPSSFNSQSSRAVILFGEQHHKLWDIVKAELKKIVPPEAYPQSEAKVNGSFRAGFGTVLFFEDTAVIKDLQQKFALYADNFPIWSEHATGIAQFAVWTTLAQEGIGASLQHYNPLIDEAVRKEWDLPASWLLRAQMPFGSIEQPAGDKTFMDDEVRFRVFK
>NZ_CP050994.1|WP_168234547.1|312379_313927_+|diguanylate-cyclase
MPATIIKERYYILTPLSFLLGALVLIATLLLAAASYLRSIDKTLAGYDHMLTSIDATLIHEMVLANRRQLGVLEASLDKQAIARGDSAINGIWAIAHQFKHDAHFLYFYNARFDRLDSYPDWPVPTDYQAQRRPWYQALASDSDELIWFGPYQEFGSDAEVLTLIKRVKDDEGQLLGLLMVDMSFNSLQAALQRAMGSDQAALYITERKDGRLVVGHNLSLLPAVSDASSQGAGLSVIRKGCHLRLPLSDIDWDLNIYLPPAHFRGNLQDTLLMVVLPALALLAIWLCSLLFLVRIFRQEQTLVQRSLCGLVQDEALMEIQLRQRTWFVHGSLGEIHQVRNSLQQGQDALLHDPLTGIMNRRAFEQDRARLAKEERPHWLVLFDVDSFKRVNDSWGHGVGDGVLFRVATIMARTLGEAQVYRIGGDEFAALLPWEQEEVEDRLTHLLARVRALKWREFEECITLSAGGARYPDDADALLDRADECLYQSKRQGRDCWHLSATSPPSKGAVVTVSV
>NZ_CP050994.1|WP_168234548.1|314171_314666_+|hypothetical-protein
MEMNKYGISAVALLGALLLGNGQAQASETLNTILGGGVGGVAGTMIGKQLGGDTGALVGAAVGGAAGGAATADRGNKNEAALGGAVGALGGAAIGKSVGGDTGRLIGAGIGGAGGSAIGARTGDSHESKNDYRGGHRYRGDNGYHNGHHKHHKKYKKRRWHDDD

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Crispr_ID: NZ_CP050994_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_4

623439-623597

Orphan

Consensus_repeat	Method
GTCACCATTACCTGTCTGAGCGTGATGATGTCGGTGGACTTCCAGCCGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_4

>merge|NZ_CP050994|4|623439-623597|CRISPRCasFinder
GTCACCATTACCTGTCTGAGCGTGATGATGTCGGTGGACTTCCAGCCGGACGCAACGCCTGTATTGGTGAGCATGCTGCCCTGACTCAGGAGCTGACATGTTCTCCATCGTCACCATTACTTGTCTGAGCGTGATGATGTCGGTGGACTTCCAGCCGGA

>NZ_CP050994|4|4|623439-623597|CRISPRCasFinder
GTCACCATTACCTGTCTGAGCGTGATGATGTCGGTGGACTTCCAGCCGGA	CGCAACGCCTGTATTGGTGAGCATGCTGCCCTGACTCAGGAGCTGACATGTTCTCCATC
GTCACCATTACTTGTCTGAGCGTGATGATGTCGGTGGACTTCCAGCCGGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_168234690.1\|626922_627816_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NZ_CP050994.1\|WP_106887897.1\|621593_622289_+\|cytochrome-o-ubiquinol-oxidase-subunit-III	unknown	unknown	gnl\|CDD\|182628
NZ_CP050994.1\|WP_168234692.1\|629283_629526_-\|DUF3297-family-protein	unknown	unknown	gnl\|CDD\|371696
NZ_CP050994.1\|WP_025327639.1\|622288_622618_+\|cytochrome-o-ubiquinol-oxidase-subunit-IV	unknown	unknown	gnl\|CDD\|182568
NZ_CP050994.1\|WP_168236510.1\|629624_630926_-\|type-II-toxin-antitoxin-system-HipA-family-toxin	unknown	unknown	gnl\|CDD\|341494
NZ_CP050994.1\|WP_168234685.1\|616604_617513_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NZ_CP050994.1\|WP_168236509.1\|627982_628405_+\|EamA-like-transporter-family-protein	unknown	unknown	gnl\|CDD\|225778
NZ_CP050994.1\|WP_163154040.1\|616184_616514_+\|DUF3634-family-protein	unknown	unknown	gnl\|CDD\|315081
NZ_CP050994.1\|WP_168234693.1\|632191_633088_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_168234689.1\|625239_625608_+\|DUF1428-domain-containing-protein	unknown	unknown	gnl\|CDD\|377795
NZ_CP050994.1\|WP_163147912.1\|613805_614246_+\|azurin	unknown	unknown	gnl\|CDD\|259989
NZ_CP050994.1\|WP_163135290.1\|619696_621673_+\|cytochrome-o-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|131890
NZ_CP050994.1\|WP_052100950.1\|630912_631209_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|213767
NZ_CP050994.1\|WP_168234684.1\|615123_616092_+\|nucleoside-hydrolase	unknown	unknown	gnl\|CDD\|239116
NZ_CP050994.1\|WP_139744965.1\|625670_626774_-\|DUF218-domain-containing-protein	unknown	unknown	gnl\|CDD\|99750
NZ_CP050994.1\|WP_168234683.1\|612466_613504_-\|FAD:protein-FMN-transferase-ApbE	unknown	unknown	gnl\|CDD\|182478
NZ_CP050994.1\|WP_168234687.1\|618574_619693_+\|cytochrome-o-ubiquinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|182518
NZ_CP050994.1\|WP_168234686.1\|617631_618075_+\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NZ_CP050994.1\|WP_168234691.1\|628593_629028_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377396
NZ_CP050994.1\|WP_168234688.1\|623820_625182_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341025

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_168234690.1\|626922_627816_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.18007e-96
NZ_CP050994.1\|WP_106887897.1\|621593_622289_+\|cytochrome-o-ubiquinol-oxidase-subunit-III	gnl\|CDD\|182628	PRK10663, PRK10663, cytochrome o ubiquinol oxidase subunit III; Provisional.	9.69133e-130
NZ_CP050994.1\|WP_168234692.1\|629283_629526_-\|DUF3297-family-protein	gnl\|CDD\|371696	pfam11730, DUF3297, Protein of unknown function (DUF3297). This family is expressed in Proteobacteria and Actinobacteria. The function is not known.	1.0164e-45
NZ_CP050994.1\|WP_025327639.1\|622288_622618_+\|cytochrome-o-ubiquinol-oxidase-subunit-IV	gnl\|CDD\|182568	PRK10582, PRK10582, cytochrome o ubiquinol oxidase subunit IV; Provisional.	5.41089e-54
NZ_CP050994.1\|WP_168236510.1\|629624_630926_-\|type-II-toxin-antitoxin-system-HipA-family-toxin	gnl\|CDD\|341494	cd17809, HipA_So_like, type II toxin-antitoxin sytem toxin HipA from Shewanella oneidensis and similar proteins. This family contains type II toxin-antitoxin (TA) system HipA family toxins similar to Shewanella oneidensis HipA, a serine/threonine-protein kinase that phosphorylates Glu-tRNA-ligase (GltX), preventing it from being charged, leading to an increase in uncharged tRNA(Glu). This induces amino acid starvation and the stringent response via RelA/SpoT and increased (p)ppGpp levels, which inhibits replication, transcription, translation and cell wall synthesis, reducing growth and leading to persistence and multidrug resistance. HipA is the toxin component of the HipA-HipB TA module that is a major factor in persistence and bioflim formation; its toxic effect is neutralized by its cognate antitoxin HipB. HipA, with HipB, acts as a a corepressor for transcription of the hipBA promoter. In the Shewanella oneidensis HipAB:DNA promoter complex, HipB forms a dimer that binds the duplex operator DNA, with each HipB monomer interacting with separate HipA monomers. The HipAB component of the complex is composed of two HipA and two HipB subunits.	2.58699e-160
NZ_CP050994.1\|WP_168234685.1\|616604_617513_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.83868e-77
NZ_CP050994.1\|WP_168236509.1\|627982_628405_+\|EamA-like-transporter-family-protein	gnl\|CDD\|225778	COG3238, COG3238, Uncharacterized protein conserved in bacteria [Function unknown].	2.15166e-18
NZ_CP050994.1\|WP_163154040.1\|616184_616514_+\|DUF3634-family-protein	gnl\|CDD\|315081	pfam12321, DUF3634, Protein of unknown function (DUF3634). This family of proteins is found in bacteria. Proteins in this family are typically between 103 and 114 amino acids in length.	7.98062e-23
NZ_CP050994.1\|WP_168234689.1\|625239_625608_+\|DUF1428-domain-containing-protein	gnl\|CDD\|377795	pfam07237, DUF1428, Protein of unknown function (DUF1428). This family consists of several hypothetical bacterial and one archaeal sequence of around 120 residues in length. The function of this family is unknown. The structure of this family shows it to be part of the Dimeric-alpha-beta-barrel superfamily. Many members are annotated as being RNA signal recognition particle 4.5S RNA, but this could not be verified.	2.03877e-57
NZ_CP050994.1\|WP_163147912.1\|613805_614246_+\|azurin	gnl\|CDD\|259989	cd13922, Azurin, Azurin is a redox partner for enzymes such as nitrite reductase or arsenite oxidase. Azurin is a bacterial blue copper-binding protein. It serves as a redox partner to enzymes such as nitrite reductase or arsenite oxidase. The copper of Azurin is tetrahedrally coordinated by a cysteine, 2 histidines, and a methionine residue. The electron transfer reactions are carried out with the Cu center transitioning between the oxidized Cu(II) form and the reduced Cu(I) form. Azurin can function as a tumor suppressor; it forms a complex with p53 that triggers apoptosis in various human cancer cells.	3.09214e-75
NZ_CP050994.1\|WP_163135290.1\|619696_621673_+\|cytochrome-o-ubiquinol-oxidase-subunit-I	gnl\|CDD\|131890	TIGR02843, Cytochrome_bo3_ubiquinol_oxidase_subunit_1, cytochrome o ubiquinol oxidase, subunit I. Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain which reacts with oxygen, reducing it to water with the concomitant transport of 4 protons across the membrane. Also known as the cytochrome bo complex, cytochrome o ubiquinol oxidase contains four subunits, two heme b cofactors and a copper atom which is believed to be the oxygen active site. This complex is structurally related to the cytochrome caa3 oxidases which utilize cytochrome c as the reductant and contain heme a cofactors, as well as the intermediate form aa3 oxidases which also react directly with quinones as the reductant. [Energy metabolism, Electron transport].	0
NZ_CP050994.1\|WP_052100950.1\|630912_631209_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|213767	TIGR03070, couple_hipB, transcriptional regulator, y4mF family. Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions].	2.37495e-07
NZ_CP050994.1\|WP_168234684.1\|615123_616092_+\|nucleoside-hydrolase	gnl\|CDD\|239116	cd02650, nuc_hydro_CaPnhB, NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. .	7.08193e-136
NZ_CP050994.1\|WP_139744965.1\|625670_626774_-\|DUF218-domain-containing-protein	gnl\|CDD\|99750	cd06259, YdcF-like, YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been idenitified. The family also includes Escherichia coli sanA and Salmonella typhimurium sfiX, which are involved in vancomycin resistance; sfiX may also be involved in murein synthesis.	2.02275e-27
NZ_CP050994.1\|WP_168234683.1\|612466_613504_-\|FAD:protein-FMN-transferase-ApbE	gnl\|CDD\|182478	PRK10461, PRK10461, thiamine biosynthesis lipoprotein ApbE; Provisional.	3.19795e-149
NZ_CP050994.1\|WP_168234687.1\|618574_619693_+\|cytochrome-o-ubiquinol-oxidase-subunit-II	gnl\|CDD\|182518	PRK10525, PRK10525, cytochrome o ubiquinol oxidase subunit II; Provisional.	0
NZ_CP050994.1\|WP_168234686.1\|617631_618075_+\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	4.17764e-19
NZ_CP050994.1\|WP_168234691.1\|628593_629028_+\|hypothetical-protein	gnl\|CDD\|377396	pfam04657, DMT_YdcZ, Putative inner membrane exporter, YdcZ. DMT_YdcZ is a family of putative inner membrane exporters from both Gram-positive and Gram-negative bacteria.	6.01806e-14
NZ_CP050994.1\|WP_168234688.1\|623820_625182_+\|MFS-transporter	gnl\|CDD\|341025	cd17472, MFS_YajR_like, Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.16869e-156

>NZ_CP050994.1|WP_025327639.1|622288_622618_+|cytochrome-o-ubiquinol-oxidase-subunit-IV
MSHSVDNHGASHGSVKSYMTGFVLSLILTAIPFWMVMDGSASHAMVLGTVVAMAVVQIFVHLIYFLHMNTSSEERWNLVALVFTVLIIAIVVVGSLWIMYNLNINMMVH
>NZ_CP050994.1|WP_106887897.1|621593_622289_+|cytochrome-o-ubiquinol-oxidase-subunit-III
MWTTTYRLTKSSASKVSISTISTRWLNSMATDVLHHSHGAHEDGHHDAGATKVFGFWIYLMSDCILFATLFATYAVLVNGTAGGPAGKDIFELPFVFAETMLLLLSSITFGFGMLAMNKNKVSAVNTWLLVTFILGAGFIAMEIYEFHHLIVNDAGPDRSGFLSAFFTLVGTHGIHVTSGLIWIIVMMVLISKKGLTERNRTRLMCLSLFWHFLDVVWICVFTVVYLMGVM
>NZ_CP050994.1|WP_163135290.1|619696_621673_+|cytochrome-o-ubiquinol-oxidase-subunit-I
MFGKLTLEAVPYHEPIIMVTIAGIILGGLAIAGLITYYSKWQYLWKEWFTSVDHKRLGIMYLILGMVMLLRGFADAVMMRGQQVMASAGSEGYLNAHHYDQIFTAHGVIMIFFVAMPLVIGLMNIVVPLQIGARDVAFPFLNNLSFWFTAAAVVLINVSLGVGEFAQTGWLAYPPLSGLEFSPGVGVDYWIWSLQISGLGTLLTGVNFFATIIRMRAPGMTMMRLPVFTWTALCANILIIASFPILTVTIALLTADRYLGTHFFTNDMGGNMMMYINLIWAWGHPEVYILVLPVFGIFSEIVATFCKKKLFGYTSLVWATVAITVLSFVVWLHHFFTMGSGANVNAFFGITTMIISIPTGVKIFNWLFTMYRGRIEFSSPMLWTVGFIITFTVGGMTGVLLSVPAANFVLHNSLFLIAHFHNVIIGGVVFGCFAGITYWFPKAFGFKLDDVWGKRAFWFWITGFFVAFMPLYVLGFMGMTRRVSQNIDPEFHGWLVVAACGAGLIAIGVLCQLIQVVVSIRDREKNRDWTGDPWGGRTLEWATSSPPPFYNFAIEPKVTGLDAFWEAKEDGSAYRQPAKYAPIHMPKNSGAGVIIAAFSVVFGFAMIWHIWWMAIAGFVGMIATWIIHSFNDDVDYYVQVDEIERIEGQHFDNINKVA
>NZ_CP050994.1|WP_168234687.1|618574_619693_+|cytochrome-o-ubiquinol-oxidase-subunit-II
MRPFEVKRGLGALLLMATAGLLSGCDMALMSPKGQVGLEQKSLILTALGLMLIVVIPVIIMTVAFARKYRASNTTAKYTPDWSHSNKIEAVVWTVPVIIVAILAVITWKTSHSLDPYKPLESDVKPIQVDVISLDWKWLFVYPELGIASVNELAFPVNTPINFRVTSDTVMNSFFIPQLGGQIYAMAGMQTKLHLIANEAGQYKGISGSYSGAGFSGMKFKAIATQDQAGFDAWVAKVKQSPKMLSTMGEFDALAKKSENHPVEYFASADPKLFVNVINKFMGGMSHGGHDAAKDGAMDHEAMKHDAAKDGAMDHKAMNHESAKEGSMDHKAMNHDAANEETMDHAAMSHGEHAGHMATSMADKSVKAGSEE
>NZ_CP050994.1|WP_168234686.1|617631_618075_+|carboxymuconolactone-decarboxylase-family-protein
MSERIQLANQVPAAISAMMGLESYLGGTDIPLSLKELIKLRASMLNGCAYCIEMHAEVAMKHGESPQRLLALSAWRESPLFDARERAVLAMTDEVTLIAENGLTEETYQQALALLGETLLAQCLMQVVTINAWNRIAVATRMEHKYP
>NZ_CP050994.1|WP_168234685.1|616604_617513_-|LysR-family-transcriptional-regulator
MLDRVRILAQVVESGSFSRAARALNLAPSSVTRTIDALEQQLGIPLFKRSTRQLVLTEQGEYFLARSVRLLEEADQLVQSLQPLQVAPEGPLRVSVFESFGTSWLAPRLPAFLARYPGVRLEIELDNRLVDLDAENVDVAVRVGRPVDSGLHSRHLLTNRTLLVASPAYLARHGEPTHPDELAHHNCLIRGHGRQRQHWYFRQGAQRHRVAVRGNLASVGGTPLLCAAEAGSGILLLSSWMVQQGLDNGTLQPLLSEWQASPYEDRHDEIHAVFRGGRFLKPQTRAFIDFLIEVMKPLQGPR
>NZ_CP050994.1|WP_163154040.1|616184_616514_+|DUF3634-family-protein
MAWLSLLVAVALIGWLMTLGRGALFEIRLAPGKVQVKRGSVPPRFLAQAKQILQQEPVRGRILGQRDGNGVRLVFSRSIPEPVAQRLRNVFPYGDYRGAAQTPDGRHSR
>NZ_CP050994.1|WP_168234684.1|615123_616092_+|nucleoside-hydrolase
MTHKIILDTDPGIDDAMAILFAEAHPAIDLLAITTVFGNATIENGTRNALWLKQKYGMKADVAQGATAPLLREPVGPTTVVHGPSGLGDVEAGEVTLTPDPRPAWQYIVETLKANPGEITLVTIGPLTNLALALEAAPEITALVKQVVVMGGAFGVNGHRGNVTPYAEANIHDDPEAADRVFTAPWPVVIIGLDVTQQSFFSSAYLDALRDDAGEPGRFLWAVSRFYLRFYSERIGLNGCHVHDPSAIAYVIDPELFTLREGPVRVIDHGPAIGHTLQKFDGKSHPHDEWADYPAQRVGVAVRDQALLALYRDTLVAWGKDC
>NZ_CP050994.1|WP_163147912.1|613805_614246_+|azurin
MKKVLTLLLLSSLAAPALADECALVIEGNDAMQFNLKEMSVPATCKEVTITLNHTGKLPVANMGHNWVLASTADYQAVATAGMSAGADHDYLPKDDARILAHTKLVGGGESTSVTFKTEGLAGKDLTFFCSFPGHFAMMKGAFKVG
>NZ_CP050994.1|WP_168234683.1|612466_613504_-|FAD:protein-FMN-transferase-ApbE
MKTLSLAPRGLLLSLMLLLTACQPAPTQTRIQGNTMGTYYAVTLSDPFPGGQAALQGELDTLLARINQEISTYDPDSLISRFNQGSGKAPMVIPASMARIVQQGMDAGRLTQGKLDVTVGPLVNLWGFGPDKRPVKRPTAEQIAKARERVGIDKLSLTPQGEHFLLGKAIPDLYLDLSTLGEGAASDDIAALLERKGVHNYLVEVAGAVRSKGHNDKGNPWRVAIVEPSDRPGAIEDVVTPNGMALSTAGSYRNYYELDGRRYSHIIDPATGEPVTHKLVSASVITPTALEADALDTALMVMGPEQAMAFATEHKLAVYLIEKTSTGFAAKHTPEFAPYLVRSKP
>NZ_CP050994.1|WP_168234688.1|623820_625182_+|MFS-transporter
MNDFTMTRGERRATWALGSVFSLRMLGMFMVLPVLTTYGMSLAGASEALIGLAIGIYGMTQALFQIPFGLLSDRIGRKPLIVGGLLMFALGSVIAALSDSIWGVIVGRALQGSGAISAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVTGPLITQAVGLSGLFWLIALLALAAIAMVIWVVPTPAAHLQNRESAMVRGGFRTVLTNGRLLKLNLGILCVHTLLMSSFVALPPLLEQAGLAREHQWQAYLVTMLIAFVSVVPFIIYAEKHRQMKRVFQACVLVMLVAELVLWQAGLQLWGLLAGLQLFFVGFNVMEALLPSLISKESPPGYKGTAMGVYSTSQFLGVAIGGSLGGLLYSLGGGPLVFGGCAVLALLWFGVSLTMAEPPYVSSLRIVLPEGVAATPALEQKIRACDGVSDVLLVPEEHSLYVKVDSKRLTRSDLERLVAL
>NZ_CP050994.1|WP_168234689.1|625239_625608_+|DUF1428-domain-containing-protein
MSYVDGFVIAVPTVNKQALIDHAGLFDPIFLEYGATRVLECWGDDVPHGKQTDFYRAVAAKEDESVVFSWVEWPSKAVRDEAMTKMMKDPRMDPASPMHQTMPFDGARMIFGGFTTVLELKG
>NZ_CP050994.1|WP_139744965.1|625670_626774_-|DUF218-domain-containing-protein
MKKTAIALTLASLLALPVVTASDAWAAPVRSLQKEQNYDQYISKRQVVDQLLADAARIFHSPARVSDAGFTAKMPSNMEQVTELLLQAHQLEPYRTDLLISAANAQIYNGNVDRAIALFEQALSTAPDDLDLNTYLATWQRFKGDQAKSDGYVKRVGELNAGRAADLQRLFDTVDRVIATPLKERQGRGEKKGRQAIVTLGYALNPDGSMHEILLGRLETTRALAQANPAALIILTGGVPQNRQTEGKLMADWLAKKGIDRSRIIEENYATSTVENALYSGYALARHEIEYATLVSSASHVRRGQTLLEIACWQSGPANIRIDSVAYPDKPLSALAKASPEELLGIYRDALRTYGLWSYRSAPLLER
>NZ_CP050994.1|WP_168234690.1|626922_627816_-|LysR-family-transcriptional-regulator
MNQDAFALLPAFVAVVEAGTFSGAARQLGLSKSVLSKKVSQLEQTLGCQLIYRTTRSLALTEAGERYFETVRHAVRLASEGEDAIGALQSAPRGLLRVTVPMVYGRRHIAPLIPEFLALYPELQLQLEMSDALQDLVAEGLDVAVRIGELEDSSLVARRLAPCHSTLCAAPAYLARAGTPRTPADLERHNCLFYSLFRGGTQWRLQGPEGEVAITPRGNFEVNNSDAIHTALLAGLGIGNMPDFIVERDLATGRLVPLLPDHALPEHGIWCLYPKRRHLPAKVEAWLGFLHERLSLR
>NZ_CP050994.1|WP_168236509.1|627982_628405_+|EamA-like-transporter-family-protein
MGALAAFAAGLLLALMIAQNGALARATDPWLGSWLAHGVGTLVAALLWCLAPRSPTPEAAPPWAWLGGLPGALTVVLAALCLNSPLDMAGTLALLLLGQLLFGALCDARGWFGLTRRLPSGKDALAALLVMAGALCIVLH
>NZ_CP050994.1|WP_168234691.1|628593_629028_+|hypothetical-protein
MTLLILLGLLNGVAVSLSRTLNGRLASARGAMTASLANHLLGFGLLGALLILKGAPWERLAGLDPWLLVGGVLGALFVAISSWAIGRVGALACALLIVAGQLLGGALLDALAGRLAASDLLGTLLVLAGAALQRWQAGKPRSSP
>NZ_CP050994.1|WP_168234692.1|629283_629526_-|DUF3297-family-protein
MSDNKPALPDHLAANPRSPHHVAECFEHEIGIRVNGKERTNVEEYCISEGWVKIPSPKAKDRYGNPMLITVKGTVEAFYA
>NZ_CP050994.1|WP_168236510.1|629624_630926_-|type-II-toxin-antitoxin-system-HipA-family-toxin
MSGSEHHRLELRLGNQLIGHLEYDSSRDAFQLGYTPEWQARGFPLSPPLTLDGSASSAQIRAYLGNLLPENRGLEHLIEALSVSRSNLFALIHGIGRDVSGAVTFTLPAESNVPTRFRPITPEELLLRLDQPEIWPLEIWDGRPRLSVAGVQAKLNLLRLEGALGFGEGALCSTHLLKFEHHPHLVINEFVTMRLATLLGLAVARVELHSTGQHRGLLVERFDRRLDEDGQRVRRRHMIDACQALGFPVARKYERNFGDGRDVAHIREGVSLPRLFSLSALCVNPALARLDMLQWLLFNLCVNNHDAHGKNYSFFVSKTGLMPTPWYDLVNVGLYPEFNQHLAMAIGDEFAPEAVNAWQLLEMAEACDLPKRLLQQTLHKMANDILHHLDAAIAMVETDNPAELAYLAGYRDDVERRCHHFQAQAALLPELQL
>NZ_CP050994.1|WP_052100950.1|630912_631209_-|helix-turn-helix-domain-containing-protein
MMADASLQTGPKELDPASLGLAIRERRKAAKMTQEVTASLCGISKKTLIKIEKGGDVYLSTLLQVMKALGLRLQLVQETGSQVASGNSQPEVGDDEWF
>NZ_CP050994.1|WP_168234693.1|632191_633088_-|hypothetical-protein
MINNIPSPDDFFTTGKGLLAYSWGIIAKLLIELENAHDYLEDVQEVSDDYWSLADKNLAISLTIAQQGVEFLLKGKIAEVSPFLLLSEPPSRWPKPNKDKNVDFSEYRTIDAQDLTIVYDTVSTAPLPKEFVIKFDEMRKKRNKIMHSIDNSDIPNFIEIMESILLMHHILFPDETFGPVRVGSLCETPDTQLGSDEWLYNNVNQEFSLIINQMNPAKVKRFFKIDKKKRAYYCPKCVSEANHDIDFEYQLARLIDGKQAVFCPICNLEYEVTRAECEYNDCLGNVIDIDGRCLTCGN

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Crispr_ID: NZ_CP050994_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_5

985374-985491

Orphan

Consensus_repeat	Method
CCGCCGTGGCTTAACTGGATTTCTCTCAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_5

>merge|NZ_CP050994|5|985374-985491|CRISPRCasFinder
CCGCCGTGGCTTAACTGGATTTCTCTCATCGAGTCTGGTTCTCCACAAGATTGCCGAAACAGGCTGGTTCATCTCTCCTCATCACCCGACCGCCGTGGCTTAACTGAATTTCTCTCAT

>NZ_CP050994|5|5|985374-985491|CRISPRCasFinder
CCGCCGTGGCTTAACTGGATTTCTCTCAT	CGAGTCTGGTTCTCCACAAGATTGCCGAAACAGGCTGGTTCATCTCTCCTCATCACCCGA
CCGCCGTGGCTTAACTGAATTTCTCTCAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_168234872.1\|993942_994917_+\|ferrochelatase	unknown	unknown	gnl\|CDD\|234585
NZ_CP050994.1\|WP_168234862.1\|977735_979364_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173883
NZ_CP050994.1\|WP_168236521.1\|997074_998655_+\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910
NZ_CP050994.1\|WP_106887064.1\|995560_996865_+\|inosine/guanosine-kinase	unknown	unknown	gnl\|CDD\|185033
NZ_CP050994.1\|WP_168234863.1\|979375_980353_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_CP050994.1\|WP_025326665.1\|990079_990679_+\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NZ_CP050994.1\|WP_168234870.1\|986856_989274_-\|carbamoyltransferase-HypF	unknown	unknown	gnl\|CDD\|223146
NZ_CP050994.1\|WP_163149108.1\|994981_995374_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226311
NZ_CP050994.1\|WP_168234860.1\|976589_977120_+\|HyaD/HybD-family-hydrogenase-maturation-endopeptidase	unknown	unknown	gnl\|CDD\|182481
NZ_CP050994.1\|WP_168234866.1\|981936_982578_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224049
NZ_CP050994.1\|WP_059168076.1\|983991_984333_-\|hydrogenase-maturation-nickel-metallochaperone-HypA	unknown	unknown	gnl\|CDD\|376468
NZ_CP050994.1\|WP_168234871.1\|993143_993788_+\|adenylate-kinase	unknown	unknown	gnl\|CDD\|234711
NZ_CP050994.1\|WP_168234865.1\|981148_981937_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224048
NZ_CP050994.1\|WP_168234864.1\|980342_981155_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_CP050994.1\|WP_106887068.1\|990972_992886_+\|molecular-chaperone-HtpG	unknown	unknown	gnl\|CDD\|235366
NZ_CP050994.1\|WP_168234859.1\|974886_976590_+\|hydrogenase-2-large-subunit	unknown	unknown	gnl\|CDD\|182482
NZ_CP050994.1\|WP_167556337.1\|986599_986851_-\|HypC/HybG/HupF-family-hydrogenase-formation-chaperone	unknown	unknown	gnl\|CDD\|223375
NZ_CP050994.1\|WP_168234867.1\|982868_983990_-\|hydrogenase-nickel-incorporation-protein-HypB	unknown	unknown	gnl\|CDD\|182479
NZ_CP050994.1\|WP_168234861.1\|977101_977632_+\|hydrogenase-2-assembly-chaperone	unknown	unknown	gnl\|CDD\|182480
NZ_CP050994.1\|WP_010674427.1\|998769_999132_+\|DUF2750-domain-containing-protein	unknown	unknown	gnl\|CDD\|378546

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_168234872.1\|993942_994917_+\|ferrochelatase	gnl\|CDD\|234585	PRK00035, hemH, ferrochelatase; Reviewed.	1.99875e-158
NZ_CP050994.1\|WP_168234862.1\|977735_979364_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173883	cd08518, PBP2_NikA_DppA_OppA_like_19, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NZ_CP050994.1\|WP_168236521.1\|997074_998655_+\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	9.95083e-67
NZ_CP050994.1\|WP_106887064.1\|995560_996865_+\|inosine/guanosine-kinase	gnl\|CDD\|185033	PRK15074, PRK15074, inosine/guanosine kinase; Provisional.	0
NZ_CP050994.1\|WP_168234863.1\|979375_980353_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	2.95485e-99
NZ_CP050994.1\|WP_025326665.1\|990079_990679_+\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	2.645e-110
NZ_CP050994.1\|WP_168234870.1\|986856_989274_-\|carbamoyltransferase-HypF	gnl\|CDD\|223146	COG0068, HypF, Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP050994.1\|WP_163149108.1\|994981_995374_+\|hypothetical-protein	gnl\|CDD\|226311	COG3788, COG3788, Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only].	3.39558e-22
NZ_CP050994.1\|WP_168234860.1\|976589_977120_+\|HyaD/HybD-family-hydrogenase-maturation-endopeptidase	gnl\|CDD\|182481	PRK10466, hybD, HyaD/HybD family hydrogenase maturation endopeptidase.	2.18447e-91
NZ_CP050994.1\|WP_168234866.1\|981936_982578_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224049	COG1124, DppF, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.84518e-68
NZ_CP050994.1\|WP_059168076.1\|983991_984333_-\|hydrogenase-maturation-nickel-metallochaperone-HypA	gnl\|CDD\|376468	pfam01155, HypA, Hydrogenase/urease nickel incorporation, metallochaperone, hypA. HypA is a metallochaperone that binds nickel to bring it safely to its target. The targets for Hypa are the nickel-containing enzymes [Ni,Fe]-hydrogenase and urease. The nickel coordinates with four nitrogens within the protein. The four conserved cysteines towards the C-terminus bind one zinc moiety probably to stabilize the protein fold.	9.15014e-47
NZ_CP050994.1\|WP_168234871.1\|993143_993788_+\|adenylate-kinase	gnl\|CDD\|234711	PRK00279, adk, adenylate kinase; Reviewed.	2.27974e-139
NZ_CP050994.1\|WP_168234865.1\|981148_981937_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	5.35779e-62
NZ_CP050994.1\|WP_168234864.1\|980342_981155_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.7981e-54
NZ_CP050994.1\|WP_106887068.1\|990972_992886_+\|molecular-chaperone-HtpG	gnl\|CDD\|235366	PRK05218, PRK05218, heat shock protein 90; Provisional.	0
NZ_CP050994.1\|WP_168234859.1\|974886_976590_+\|hydrogenase-2-large-subunit	gnl\|CDD\|182482	PRK10467, PRK10467, hydrogenase 2 large subunit; Provisional.	0
NZ_CP050994.1\|WP_167556337.1\|986599_986851_-\|HypC/HybG/HupF-family-hydrogenase-formation-chaperone	gnl\|CDD\|223375	COG0298, HypC, Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones].	8.26096e-28
NZ_CP050994.1\|WP_168234867.1\|982868_983990_-\|hydrogenase-nickel-incorporation-protein-HypB	gnl\|CDD\|182479	PRK10463, PRK10463, hydrogenase nickel incorporation protein HypB; Provisional.	3.49876e-144
NZ_CP050994.1\|WP_168234861.1\|977101_977632_+\|hydrogenase-2-assembly-chaperone	gnl\|CDD\|182480	PRK10465, PRK10465, hydrogenase-2 assembly chaperone.	1.0307e-86
NZ_CP050994.1\|WP_010674427.1\|998769_999132_+\|DUF2750-domain-containing-protein	gnl\|CDD\|378546	pfam11042, DUF2750, Protein of unknown function (DUF2750). This family is conserved in Proteobacteria. The function is not known.	3.8262e-36

>NZ_CP050994.1|WP_059168076.1|983991_984333_-|hydrogenase-maturation-nickel-metallochaperone-HypA
MHEMSLAMAAIDLAAEQATQRGFNKVTALWLEVGSFSCVDPDTIAFCFEAAAKGTVVEGAQLHFQHQAAEAWCYDCNKTVTLTERGQACPECGGYKLRVAQGDSLRITDIEVS
>NZ_CP050994.1|WP_168234867.1|982868_983990_-|hydrogenase-nickel-incorporation-protein-HypB
MCSVCGCGQARIAGHKEDHDHAHPHAHDHEHHHHHEHEHGHPHTHEAQHDHEQSTPRTLIIHHHYHHQGDVHHHYHGVRAPMSHEGHDQPYEHHHDHPHDHHHDHAHSHDHGHSHTHPHDHSHDHDHDHDHDHDHDHDHQQGELHYGKGEAGLSVPGMEQRQLIAIEMDVLAKNNALAAHNREHFDEAAQLVLNLVSSPGSGKTTLLCETLRQLADKRPCAVIEGDQQTSRDADRIRATGVPAVQINTGKGCHLDAKMVHDACHQLPANEGGILFIENVGNLVCPASFDLGEKYKVAILSVTEGEEKPLKYPDMFAAAQLMVINKIDLLPYVSFDVARCIENAKRVNPYIQVIQVSATTGEGMDAWLNWLASA
>NZ_CP050994.1|WP_168234866.1|981936_982578_+|ATP-binding-cassette-domain-containing-protein
MLEVRNLTIAQGERPLWQGLSLAVKAGERLGISAPSGYGKTTLGRVLAGWQPVRGSGEMLLDGQPVPEQVKGYNPIQLVPQHPELTFNPYRTTGQALWDVWRPDEAMLARFMVKPEWLGRKPGQLSGGELARIALLRALDPRTRLLIADEVTAQLDPQIQCHIWRELMVECEQRGLGMLVFSHQQALLRQICHRVLRFSEAPAEQEAMARSVA
>NZ_CP050994.1|WP_168234865.1|981148_981937_+|ATP-binding-cassette-domain-containing-protein
MLSFDHVTIEAAHYSWLGRRSWQPLLTDISLQLAPGEIVALVGGSGEGKSLLLQSALTLLPDNLRMRGAISLDGTPLCDASRARLRGHTLCYVPQGVSALNPLLTVERQLGRAARLCGQNGSRERLGEQLLRYQLPAATLDRYPRQLSGGMVKRILACTAALGGARYILADEITAWLDEGLACLLLSQLRELANQGSGILWVTHDLALAARFADRIVALHQGKVSDTLSSHHLRQGQGSEMLRAHWQALPEFNALFSVPEVS
>NZ_CP050994.1|WP_168234864.1|980342_981155_+|ABC-transporter-permease
MLFNPLPSILRLGFALLGLALLAAYGWNLSHQDVPMDLLARQQPPSLAHWFGTDQMGRDLWLRAFQGTLTSLELGISTALCSGLLAMVAASVSLIHPRCDVAVRLLIDAMLALPHMLLLILICFTVGGGMRGVILAVALTHWPKLALILCAEARRIACSDYVVLARCQGMGALRRWRTHLLPGLLPQWFIGTLLMFPHAVLHSAALSFLGFGLAAHEASLGLLLADALRYLAGGGWWLALFPGLMLLLLVLLFDQATRALQQLWFGSEPC
>NZ_CP050994.1|WP_168234863.1|979375_980353_+|ABC-transporter-permease
MMTASLKALLRLAGLLCLVSVATFVLLSYSPIDPIKAYIGNDLLHVPPEQYARIAARWGLDQPLWLRYWHWFGQVLKGDLGYSMLYNAPVGEVIGQRFAASFLLLAGAWLLSGFFGILLGLCAGRYLNRWPDRLICRFAYLLASLPTFWVGLLLLALFAVHWPLLPVCCAWTPGLAADEADWFMRLRHLLLPVTTLALLGVGNIALHTRGRVAEVLESDFIRYARAQGDGGWPMLRFHVLRHALTPALCLQFASLGELIGGSLLAEKVFSYPGLGQATVDAGLRGDIPLLMGIVLFCTLLVFIGNTVASLLLARINRGWEGEHAV
>NZ_CP050994.1|WP_168234862.1|977735_979364_+|ABC-transporter-substrate-binding-protein
MTIPRHARIQVRPYGAPVVATLLLALLSGMFHSVQAAQPVPAELKLAIGAEPTEGFDPLLGWSHGSYLLLHSPLLKQIAGDSADLGWQDLLTESVTPNQDGKGWLITLKPDLKFSNGAPLTAEDVAFTYNSAAKGGGKIDMGNFVKAEVVSPTEVAIVLSAPQSTFVNVLGSLGIVSKRDYDAKAYAQKPVGAGPYRLVSFLPGQQLVVEENPHYAGGSNDFKRLVFVFIDEESAYAAAQSSQLDLVRIAPSLAPTEPASLKLWVRPSVENRGIVFPIPPAGGKDAKGYAIGNDVTADVAVRRAINYAIDRQLLADQLLEGHAIPAYSAVEGLPWNNPAAAFKDGDVTHANALLDEAGWKMGSDGIRHKGNLRAAFTLWYTSGDSTRRDLAEVVRAMLKPIGLEVSLKSGSWEQVEREMHANPVLMGWGSLDPMELYHHYQSGSGGVEFYNPGYYSNPVVDGHLKQALDAPNWQAAVPFWQQVEWDGKTGAGVQGDAAWAWLLNVQHTYLANRCIDLGKGAPEIHGSWSLLNNLSDWRWTCR
>NZ_CP050994.1|WP_168234861.1|977101_977632_+|hydrogenase-2-assembly-chaperone
MAQSHLSELDDVQEFIGFASNPATLLVAQYELIAREQMQGLPFYHATMPIVAECVLFEGQWLGCVLTPWMLSLVVLPGPDQLWPVRSSSDRLALQLPCGNMTFMVGELPETGQLLACSLMSPLDPHLGAEQGRALVSSTLKMLLSLPVQQGAGGVDLGRRRLFGARRSQGLEATES
>NZ_CP050994.1|WP_168234860.1|976589_977120_+|HyaD/HybD-family-hydrogenase-maturation-endopeptidase
MNTLILGVGNLLLSDEAVGVRIVEALGREYRFAPGIELLDGGTAGMELLEAMASRDHIILADAVRSGNPPGTVVTLQGEEIPTLFGRKISPHQLGLADVLSALHMTGESPKRLTLIGIEPESLEPRIGLTPLVAAAMGEAKDRILTLLASVGAPAMPLSEQEKAKQEQEGLWRSPI
>NZ_CP050994.1|WP_168234859.1|974886_976590_+|hydrogenase-2-large-subunit
MSQRITIDPITRIEGHLRIDCEIEGGIVTKAWSSGTMWRGMEEIVKGQDPRDAWMIVQRICGVCTSIHAIASVRAVENAIGAKVPVNAQFIRNLIIAAHNIHDHIVHFYQLSALDWVDITAALQANPQKAADILKGVSTWSLNSAEELTKVQDKIRALVASGQLGIFANGYWGHKEMKLSPEVNLIAVAHYLQALECQRDANRIVAILGGKSPHIQNLAVGGVANPINLDAPSVLNLERLMYVKSFIDRLGEFIEQVYKVDAAIIAAHYPEWLALGQGAKHYLSVPELPTDADGGSFLMPGGYIENGNLAGYRPIESHQDAWLMDGIAESNKHAWYKDDEPLKPWEGKTEPNYTGWQDDGKYSWVKSPTFYGKVVEVGPLADLLVKLAAKHPETVAHFDQLNGIYKALTGSAIKTEQLHSTMGRIIGRAVRCCVLKDTLAHQWKALIDNIGKGDFTAYIKAEIPADKEFRGVGFEEAPRGMLSHWIVIKEGKIANYQAVVPSTWNSGPRNFNDEPGPYEQALVGTPVADPAKPLEVVRTIHSFDPCMSCAVHVVDTQNGETTQVKVL
>NZ_CP050994.1|WP_167556337.1|986599_986851_-|HypC/HybG/HupF-family-hydrogenase-formation-chaperone
MCLSIPSQVVQLHPEDNCVTVDTLGVQRRVSCMLLEEPLQVGDYVLLHIGFVMSKIDEAEAQASLESFRQMVALMPEQDILPC
>NZ_CP050994.1|WP_168234870.1|986856_989274_-|carbamoyltransferase-HypF
MTARTQTPSRLRREFHMDGIVQGVGFRPFVYGLALRHGLAGYVLNDANGVTIGVEGEPEQLAAFARELRELAPPLSRIDHFSQRDLPFAHDPDYDGAFHGQFRIKASQQQSAATVAISPDQGMCEACATDVANPADRHHHYPFTNCTHCGPRYTIIRRLPYDRPHTAMADFAMCPRCAAAYENPLDRRYHAQPVSCPECGPHLTWRSGHGDALAEREDALQAAARALQAGALIAVKGMGGYHLICDARNELSVARLRTLKRRERKPLAVMMGSLAEAKLHVTGCEAEWKLLASQARPITLLRKRTNDDRLSESRPSAAPLAEGIAPGIPYLGVMLPYTPLHQLLLDACAMPLVATSANGRGSPILIECEAVVRELSSEIDGILDHNRPILHPCDDSLVQWAGGRRQTLRLARGYAPCTPSLKEAVNLPLLAVGAQQKNQLALAFGRQRIYSPYIGDLHSLPMQGHFEQTLATFRDLYDLKPELLVSDLHPGYLSHQWAKGYCQDQGATHLEVQHHHAHLLAVMAEHDITGPVLGVAFDGTGLGDDGTLWGGELLLADVKGFTRVAHLQPFKLIGGEAAIREPVRQLLGLLFESHSPEEISALDIPLINKLPPERINNLHQLWHLGRNTPHTSSIGRLFDAVAALLGVIDTPDYEGEAGLLLEAAALQLAPDEQPFPLAFGLSQSAEGPLHIEWAELLNTLVGERRKGTSTASLAAGFIRAISALVVALAERFPGYPVALGGGVFQNRVLMDEIVPALEAAGRQVLTSETLPLNDGGIAAGQLWFAIHHIATHQPATTGCATLSES
>NZ_CP050994.1|WP_025326665.1|990079_990679_+|recombination-protein-RecR
MKFSPLLDEMMKALQVLPGVGPKSAQRMAFTLLERERSGGLRLASLLNRALTEIGHCSHCRTFTENDRCEICANPKREENGLLCVVESPADVAAIEQTGQFSGRYFVLMGHLSPLDGIGPEELGLEILERRLKDEHIKELILATNPTIEGDATAWYIADMARAAGVEVSRIAHGVPVGGELELVDGTTLSHSLMGRQRI
>NZ_CP050994.1|WP_106887068.1|990972_992886_+|molecular-chaperone-HtpG
MTQSVHAETHGFQTEVKQLLSLMAHSLYSNKEVFLRELISNASDAADKLRFKALSDASLFENDGQLRVRLVVDKENKTLTISDNGIGMTRDQVIEHLGTIAKSGTAEFFKHLSGDQGKDSQLIGQFGVGFYSAFIVADKVTVISRAAGTEPGQGVQWESEGEGSFTVADVTKEGRGTDVILHLRAEEEEFLDDWRLRAVVAKYSDHISVPVEMYKEGTPDREEDGETIVGTPGEWEQVNRATALWTRNPKDIKDEEYQEFYKHVAHDFEDPLLWGHNRVEGAQEYTSLLYIPARAPFDLYNREQKHGLKLYVQRVFIMDDAEQFMPTYLRFVKGVLDSNDLPLNVSREILQDNKVTASLRKACSKRVLTMLNKLAKDDSEKYAKFWSEFGNVLKEGPAEDYANREEIAKLLRFASTAGEGEAQTVSLEDYVGRMKEGQQKIYYITADSYAAAKNSPHLEIFRKKGVEVLLMWERVDEWLMSHLTEFDGKQLVSVTRGELDLGELEDEASKQAQEEAEKANAGLVARVKQSLADAVKEVRVTHRLTDSPSCIVTDDHGMSTQMIKLMRAAGQPVPEQKYILELNPDHALVKKLDTIEDEALFGEWVSLLHEQAQLAEQGGLNDPASFVSRINRLLLQA
>NZ_CP050994.1|WP_168234871.1|993143_993788_+|adenylate-kinase
MRIVLLGAPGAGKGTQAQFIMEKHGIPQISTGDMLRAAIKAGTELGLKAKAVMDAGQLVSDDIIIGLVKERIAQPDCANGFLLDGFPRTIPQAQAMKDAGVVVDFVLEFAVPDEEIVKRMSGRRVHSGSGRTYHVVFNPPKVEGKDDVTGEDLVIRADDEETTVRKRLDVYHQQTAPLIGFYGKEAEAGNTRYVKIDGTQPVDKVSQQLAAILG
>NZ_CP050994.1|WP_168234872.1|993942_994917_+|ferrochelatase
MTTKTGILLVNLGTPAAPTSAAVKAFLSQFLQDPRVVEIPRLLWAPLLTFAILPFRAPRVAKLYQQVWTEQGSPLMAISQRQRAALEQELKREGVDVPVVLAMTYGSPSLDEGWQALKAQGVNRVILLPLYPQYAASTTAAVFDGWARVMKKERHLPVMRLIRDYHNHPEYIQALAMSVRRQWEQQGQGEHLLMSFHGIPQRSEDEGDPYGHQCRRTAALLAEALGLSPEQWSASFQSRFGKQEWLKPYTDVTIAQLGAQGVKRLDVICPAFSADCLETLEEIQVENRTVFMDAGGEQFHYIPALNSDQAHIRMMVSLICRELA
>NZ_CP050994.1|WP_163149108.1|994981_995374_+|hypothetical-protein
MMHITLIYGGLLGLLFLLLSFWVVKRRAQFKVMIGEGEAPEMLSAIRAHGNFAEYVPLTLLLMALCELAGVGALWLHLGGGLLLLGRILHAIGIQIPKAPNKPRLFGTLFFWLSLGLFSVLALVQGLSFG
>NZ_CP050994.1|WP_106887064.1|995560_996865_+|inosine/guanosine-kinase
MKFPGQRKSKHYFPVDRRDPLIPQNPQLTELGKAYVVGIDQTLVDIEAHVDEDFLNRYGLSKGHSMLISDDVAERVYEELKANNMVVSEFAGGTIGNTMHNYSVLADSHSILLGVMSQDIRIGSYAYRYLCNTSSRVNLDYLQPVDGPVGRCFTFITEGGERSFGINAGKMDHLDVAHIPEAIIKDSSALVITAYLVRGADGTPMKEAAMAAVRYAREAGVPVVLTLGTRFVIDENPQWWRDFISENVTVLAMNEDEAEALTGIKDPLGAADKALDWADMVLCTAGPIGLYMASYTEEDYKRETTHTLLPGVIPEFNMYEFSRPMAREKCRNPARIYSHISPYMGGPEKIKNTNGAGDGALSAVLHDMVANAYHRMNVPNSAKHLSEFLTYSSLAQVCKYANRVSYEVLAQSSPRLSRGLPEKEDSLEEVYWER
>NZ_CP050994.1|WP_168236521.1|997074_998655_+|methyl-accepting-chemotaxis-protein
MVLALLGLLLFFCLQIYQQGLMGGKSRQTQAQVETAYSLVAGFEARVRKGELDEGRAKAEALAAIKGLRYGEEDYFWINDSHPTMVMHPMKPELDGKDLSGVEDKQGLRLFVAFADLAKAQGAGEVAYYWPKPGVEEPVRKISYIKRFAPWDWIIGTGVYVDDVEAQYQEVLRTLLGIGLVLAILLFAVVGLIVRSIVVPLSQSVSALGNIARGEGDLRFRLPESGRDELSQLSVNFNLFAGQMAQLVGRSQQITAQNREQAHQLAQIVDRTGAIVTGQEQDTLRVASAMEQMTVSSREVGQHAAQAAEAADSALNLAQHGRQVVAQTRETISQLADEMVETVQAVSQLEQETQQIGSVLDVIRGVAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRTLATRTHSSTDEIRQMILRLQEGAGRVVSGITQLQQLSRSTADRAGDADGAIHAIDGSVHTINAMNSQIATAAAEQSRAAEEINQRLVAITELAADALAQNRLTEQAASQLALSCDELGALVAQYRT
>NZ_CP050994.1|WP_010674427.1|998769_999132_+|DUF2750-domain-containing-protein
MSKLTDNLDANFQLFIEEVRESGQVWGLRYGEDWVVCRSAEFEDADVMPLWSAEGDARLHCVDEWADYEPEVIELEEFLDIWINDLDEDDVLVGPNWNADLEGQELEPIELAKALVELDA

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Crispr_ID: NZ_CP050994_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_6

1619069-1619221

Orphan

Consensus_repeat	Method
TGAGGGTCATGACGACAGCGCTACATTGGCGCTCATTGCCAATCCACAAGGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_6

>merge|NZ_CP050994|6|1619069-1619221|CRISPRCasFinder
TGAGGGTCATGACGACAGCGCTACATTGGCGCTCATTGCCAATCCACAAGGGGTGCACATTTGGCTGTTCACTCCCTTCCCCGGGGATTGCCAGCAACCCTGAGGGTCATGATGACAGCGCTACATTGGCGCTCATTGCCAATCCACAAGGGG

>NZ_CP050994|6|6|1619069-1619221|CRISPRCasFinder
TGAGGGTCATGACGACAGCGCTACATTGGCGCTCATTGCCAATCCACAAGGGG	TGCACATTTGGCTGTTCACTCCCTTCCCCGGGGATTGCCAGCAACCC
TGAGGGTCATGATGACAGCGCTACATTGGCGCTCATTGCCAATCCACAAGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_168235171.1\|1604665_1604911_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_168235176.1\|1617673_1618459_-\|DTW-domain-containing-protein	unknown	unknown	gnl\|CDD\|225690
NZ_CP050994.1\|WP_025327090.1\|1616562_1617342_-\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|182593
NZ_CP050994.1\|WP_168235178.1\|1621364_1621841_+\|glutathione-peroxidase	unknown	unknown	gnl\|CDD\|223463
NZ_CP050994.1\|WP_168235181.1\|1625056_1625902_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_168236543.1\|1624589_1624922_-\|YnfA-family-protein	unknown	unknown	gnl\|CDD\|235016
NZ_CP050994.1\|WP_168235183.1\|1626741_1627134_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240046
NZ_CP050994.1\|WP_168235174.1\|1614649_1615567_+\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|273359
NZ_CP050994.1\|WP_168235182.1\|1626172_1626745_+\|class-IV-adenylate-cyclase	unknown	unknown	gnl\|CDD\|143628
NZ_CP050994.1\|WP_168235172.1\|1605570_1606827_+\|M20-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|349915
NZ_CP050994.1\|WP_168235179.1\|1622118_1623519_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|236722
NZ_CP050994.1\|WP_111911892.1\|1606899_1607580_-\|pyrimidine-5'-nucleotidase	unknown	unknown	gnl\|CDD\|181865
NZ_CP050994.1\|WP_106886690.1\|1610883_1611603_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_168236542.1\|1624092_1624554_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP050994.1\|WP_168235180.1\|1623593_1624034_-\|acetyltransferase	unknown	unknown	gnl\|CDD\|182510
NZ_CP050994.1\|WP_139434330.1\|1613603_1614491_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225117
NZ_CP050994.1\|WP_111911876.1\|1619346_1620333_-\|D-alanine--D-alanine-ligase	unknown	unknown	gnl\|CDD\|234993
NZ_CP050994.1\|WP_168235184.1\|1627249_1627756_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_CP050994.1\|WP_168235173.1\|1607609_1609094_-\|leucyl-aminopeptidase-family-protein	unknown	unknown	gnl\|CDD\|238247
NZ_CP050994.1\|WP_168235175.1\|1615619_1616555_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_168235176.1\|1617673_1618459_-\|DTW-domain-containing-protein	gnl\|CDD\|225690	COG3148, COG3148, Uncharacterized conserved protein [Function unknown].	3.38036e-81
NZ_CP050994.1\|WP_025327090.1\|1616562_1617342_-\|TSUP-family-transporter	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	7.85103e-101
NZ_CP050994.1\|WP_168236543.1\|1624589_1624922_-\|YnfA-family-protein	gnl\|CDD\|235016	PRK02237, PRK02237, YnfA family protein.	4.76666e-46
NZ_CP050994.1\|WP_168235183.1\|1626741_1627134_+\|NUDIX-domain-containing-protein	gnl\|CDD\|240046	cd04690, Nudix_Hydrolase_31, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	2.10628e-39
NZ_CP050994.1\|WP_168235174.1\|1614649_1615567_+\|EamA-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	7.97215e-14
NZ_CP050994.1\|WP_168235182.1\|1626172_1626745_+\|class-IV-adenylate-cyclase	gnl\|CDD\|143628	cd07890, CYTH-like_AC_IV-like, Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily. This subgroup contains class IV ACs and similar proteins. AC catalyzes the conversion of ATP to 3',5'-cyclic AMP (cAMP) and PPi. cAMP is a key signaling molecule which conveys a variety of signals in different cell types. In prokaryotes, cAMP is a catabolite derepression signal which triggers the expression of metabolic pathways including the lactose operon. Six non-homologous classes of ACs have been identified (I-VI). Class IV ACs are found in this group. In bacteria, the gene encoding Class IV AC has been designated cyaB and the protein as AC2. AC-IV occurs in addition to AC-I in bacterial pathogens such as Yersinia pestis (plague disease). The role of AC-IV is unknown but it has been speculated that it may be a factor in pathogenesis, perhaps providing cAMP for a secondary internal signaling function, or for secretion and uptake into host cells, where it may disrupt normal cellular processes. This subgroup belongs to the CYTH/triphosphate tunnel metalloenzyme (TTM)-like superfamily, whose enzymes have a unique active site located within an eight-stranded beta barrel.	8.9707e-48
NZ_CP050994.1\|WP_168235172.1\|1605570_1606827_+\|M20-family-metallo-hydrolase	gnl\|CDD\|349915	cd05665, M20_Acy1_IAAspH, M20 Peptidases aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase. Peptidase M20 family, bacterial and archaeal aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase (IAA-Asp hydrolase; IAAspH; IAAH; IAA amidohydrolase; EC 3.5.1.-) subfamily. IAAspH hydrolyzes indole-3-acetyl-N-aspartic acid (IAA or auxin) to indole-3-acetic acid. Genes encoding IAA-amidohydrolases were first cloned from Arabidopsis; ILR1, IAR3, ILL1 and ILL2 encode active IAA- amino acid hydrolases, and three additional amidohydrolase-like genes (ILL3, ILL5, ILL6) have been isolated. In higher plants, the growth regulator indole-3-acetic acid (IAA or auxin) is found both free and conjugated via amide bonding to a variety of amino acids and peptides, and via an ester linkage to carbohydrates. IAA-Asp conjugates are involved in homeostatic control, protection, storing and subsequent use of free IAA. IAA-Asp is also found in some plants as a unique intermediate for entering into IAA non-decarboxylative oxidative pathway. IAA amidohydrolase cleaves the amide bond between the auxin and the conjugated amino acid. Enterobacter agglomerans IAAspH has very strong enzyme activity and substrate specificity towards IAA-Asp, although its substrate affinity is weaker compared to Arabidopsis enzymes of the ILR1 gene family. Enhanced IAA-hydrolase activity has been observed during clubroot disease in Chinese cabbage.	0
NZ_CP050994.1\|WP_168235179.1\|1622118_1623519_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|236722	PRK10590, PRK10590, ATP-dependent RNA helicase RhlE; Provisional.	0
NZ_CP050994.1\|WP_111911892.1\|1606899_1607580_-\|pyrimidine-5'-nucleotidase	gnl\|CDD\|181865	PRK09449, PRK09449, dUMP phosphatase; Provisional.	4.03853e-77
NZ_CP050994.1\|WP_168235178.1\|1621364_1621841_+\|glutathione-peroxidase	gnl\|CDD\|223463	COG0386, BtuE, Glutathione peroxidase [Posttranslational modification, protein turnover, chaperones].	6.15906e-91
NZ_CP050994.1\|WP_168236542.1\|1624092_1624554_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	9.82209e-16
NZ_CP050994.1\|WP_168235180.1\|1623593_1624034_-\|acetyltransferase	gnl\|CDD\|182510	PRK10514, PRK10514, putative acetyltransferase; Provisional.	2.64822e-45
NZ_CP050994.1\|WP_139434330.1\|1613603_1614491_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	4.27195e-31
NZ_CP050994.1\|WP_111911876.1\|1619346_1620333_-\|D-alanine--D-alanine-ligase	gnl\|CDD\|234993	PRK01966, ddl, D-alanine--D-alanine ligase.	8.43236e-140
NZ_CP050994.1\|WP_168235184.1\|1627249_1627756_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.04036e-11
NZ_CP050994.1\|WP_168235173.1\|1607609_1609094_-\|leucyl-aminopeptidase-family-protein	gnl\|CDD\|238247	cd00433, Peptidase_M17, Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and play a key role in protein degradation and in the metabolism of biologically active peptides. They do not contain HEXXH motif (which is used as one of the signature patterns to group the peptidase families) in the metal-binding site. The two associated zinc ions and the active site are entirely enclosed within the C-terminal catalytic domain in leucine aminopeptidase. The enzyme is a hexamer, with the catalytic domains clustered around the three-fold axis, and the two trimers related to one another by a two-fold rotation. The N-terminal domain is structurally similar to the ADP-ribose binding Macro domain. This family includes proteins from bacteria, archaea, animals and plants.	5.49575e-137
NZ_CP050994.1\|WP_168235175.1\|1615619_1616555_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	3.48126e-30

>NZ_CP050994.1|WP_168235176.1|1617673_1618459_-|DTW-domain-containing-protein
MKPIPDHAVNRLRIWRKSISTRPFLARGGSVPRCEACQLRHAWCACEWRPELKAEAGFCLLMYDSEPMKPSNTGRLIADVLPQTTWAFLWKRTQPHPELLTLLADPAWQPYVVFPACEKNPARVTERVALAPGKKPLFILLDGTWPEARKMFNMSPYLDGFPVLSVRPDALSTYGMRVAHCDEHLCTAEVAACVLEVAGELQAGQALQHWFNLFSSRYMAGRVSRAPGEDETSLLQALEAIKGEVAESAADRGEASVATLV
>NZ_CP050994.1|WP_025327090.1|1616562_1617342_-|TSUP-family-transporter
MELELLTLVALFGVALIAGFIDAIAGGGGLLTVPALLATGMPPALVLGTNKLQSSFGSFSATWFYARKGLLEWAIIWPAVICTFIGAAIGTLAVQTIDAAILERLLPFLLMAFACYFYFSPRVSDAESQRRLTPMLFALLVGGGVGFYDGFFGPGTGSFFAIGFVALAGFGMARATAHTKLLNFTSNIASLLFFALGGKVVWSVGFCMALGQFIGARFGSKLVLKKGVKLIKPLLVTVSLVMSAKLVWSQYPELFSWLV
>NZ_CP050994.1|WP_168235175.1|1615619_1616555_+|LysR-family-transcriptional-regulator
MLLEGLETLCLLASEGTMAKVASRLYISQSAVSKRITQLEQRLGKRLIEPDGRQTRLTPQARELLARVAPSLAEMKGVLADSQTLTDQTPLPVACSETLLAGYLARFMHDYLEQDPHLALSTHHTPVILTRVRGGDALLGICAGRLPPGHGLCAELLLEEPFYLVGDDQEAAAQPDHRVASPDRASGKPLTQRDLGEETLVQEKVRKILTMDLENPSNRYLRDPLAALGLVPAMALDSYLALIELAKAGIGPVLLPAGLLALVGDQGKRARALPGLARPLHLVYRPSSLKRARIQRLVEGIRAHFARVSQG
>NZ_CP050994.1|WP_168235174.1|1614649_1615567_+|EamA-family-transporter
MNLLLYVSTVLIWGSTWIAIAWQLGPIPIEVSVLYRFALAALALFALLTLSGKFPRLPWAGQRYAALLGALLFSTNFLCFYHATLYIPSGLSAVIFASASIFNGLNLWLFEGKRPGMRWLQGSLLGLMGTLLLFWHVLADAQLGANGWKGLLFACAGTLCFSLGNLVSARGQRQGYQVLQMVPWGMVYGVALLLGWVMVLGQSLTLPTEPRYLAAMVYLAIFGSVIAFTAYLTLVGRIGASKAAYATVLFPLVALSLSTLYEGFVWQTVSILGVVVSLIGNLVIFAPPVKTWRWPLSRVTDGTCP
>NZ_CP050994.1|WP_139434330.1|1613603_1614491_-|helix-turn-helix-domain-containing-protein
MQQRRQAGVFDALVSTGARLEDSCWLEPGLGVASWRNRYDQTRYHKPGHHTISVYLQGGEQTERLDGPGGHGGTGKVCIMPDHHRSEWLVREEFRFFHLYFTPEHLCRIAEQVCDKEGRHLVLQDKTFIEDPQAAALVQAQLMKLDWQHGVDRMALSHGAWMLMLHAYRHHTREAPGLPEVRGGLAPAVIRRVQEYLLAHLAEPVTLSELAREAGLSEYHFARMFGQSLGCPPHRYLQGLRLQRAKQLLAGSDPLASIAAQCGFSSQAHFGNRFREAFGLSPGQWRAQLSFSCHR
>NZ_CP050994.1|WP_106886690.1|1610883_1611603_-|hypothetical-protein
MFVQLPFWLFSLTGLMALGALIALGIVLWRGDLCPGQRSRITNQLFSIWVITGLSLMLGIEAGVTGWLIWCGGAALILGIVLSLAQSRLEGKRAIPASLLWLPAMPLALYGLGLLQIQGWLNGALQMVLLGSAFAHLMLLRARHRLQAFNLLLPLAGLLAAMLSLIWLAVLVSGQDNGAGLDALIPGVLTQAGLLIAALLLWFSPIYRQQETAPVVLSVTLCGLIIAQIAATSVLHQLV
>NZ_CP050994.1|WP_168235173.1|1607609_1609094_-|leucyl-aminopeptidase-family-protein
MMHAFNYLAPKITMQTSTLNEVMASDIPVKLLLVAETGRDALLAQPAFAGVTAQIALGLPAPYRLADGQGLQLVLFVDSAPVLDHRLYKQIRTWTAPLAGLKVAQLALHLEGFDEAPRALLAELVLATLLAADVPLPTHKRANEAPIGYQSLTLSPPCALDLARIEAEAQGNGLARHLAVLPASELSAGSYRAFARQLAQAEGWQWEEFDETALAKLGAGAFLAVARGSEDNQAAIVRLSYCPANPVRRIALVGKGICHDSGGYNLKVGGSMYGMHLDMGGSAAALGTLHAISRAKLPYEVHCWLAIAENHIGPRAYRPGEVVTALNGTTIEVVDTDAEGRMVLADALSLAAKGEPDLLIDYATLTGACKRALGSRYSGAFTNRPDWLPELIRLGQQSGERIWPFPLDEDFDDNLDSEWADLLQCAPGSSPDHIDAARFLSRFVPGQTPWLHLDLSGFRNKGGNGVVGSEVTGFGVRLSLTLLASPLGMAEPAT
>NZ_CP050994.1|WP_111911892.1|1606899_1607580_-|pyrimidine-5'-nucleotidase
MKQASYDWVLFDLDETLLDFPVAKALERTLQIYGVTPTPPRMAAYHELNHRLWQQYNSGEIDATWLQQTRFSMFAEQVDVAPMAMNDTFLQQIIALSVPLEGVEETLLALKSRVRMGIITNGFSLPQRGRLDKLGWNEWFEPLVISDEVQVTKPAAAIFQHALDLMGQPSPARVLMVGDNPKTDIAGAAAQGLATCWYNPARQQGPCEATHEIHHFAHLSDIVLGR
>NZ_CP050994.1|WP_168235172.1|1605570_1606827_+|M20-family-metallo-hydrolase
MTQDALRHWRRDLHRLPEAAWCEFRTSALIAHHLSELGFSVMLGDKLLASNLIMGREIDVAAQKERALRQGAHPDWLARIDEITGVMGVWDSGRPGPTLGFRFDIDAVEVEESREPAHQPCQEGWHSANPGWMHACAHDGHTAIGLVLAERISALAERLNGRIKLFFQPAEEGCRGGKALAAGGQLDDVDALLALHIGIHANSGELVVNPTEFLCSTKFDVEFMGRAAHAGLEPNAGSNALAAACMATTAMLGIARHRDGMTRMNIGQLNGGSGRNVIPGHARLQGETRGATPALNDYMFGQVQQIVEGAAMMQGASYLIRKQGEAIGIENSPALLEEIVPLAEALKLETIHSRRFGASEDAGFLIERVQQNGGQAAYLILGANLAAPHHHPEFDFDEAVLAPGVALLEAWLLSRLGT
>NZ_CP050994.1|WP_168235171.1|1604665_1604911_-|hypothetical-protein
MRLKVSPMMGWLAGITISLVSSLLPARHGISPVWAVLYRHHLPAEFQFTEENRAKQQTFGRRKTRSTARQVALFGHYWLQV
>NZ_CP050994.1|WP_111911876.1|1619346_1620333_-|D-alanine--D-alanine-ligase
MKNMHVLLLCGGGGAEHEVSLRSANFLEQQLGLLPGVEVTRVEMFADRWLSADGRECKLGLDKLLSFDSVARPVDYVVPCIHGYPGETGDLQSFLELAGLPYLGCDAEASKICFNKISTKLWLSAIGIPNTPYLFLTEQGDEALSEARAALAKWGKVFIKAASQGSSVGCYSASNEAELVQGIKDAFGYSEQVLIEKAVKPRELEVAVYQYGDELVATYPGEICVPQDKFYTYEEKYSSASHTETALKAEGLTQAQSDAIHAYSLKAFRQLKLTHLSRIDFFLTEDGEILLNEINTFPGMTSISMFPKLLEHHGHSFARFLEQNLRPV
>NZ_CP050994.1|WP_168235178.1|1621364_1621841_+|glutathione-peroxidase
MPLPTIPLQRLDGSEFPGDALQGKVLLVVNVASRCGFTPQYTGLEALYRQFGEQGLVVLGFPCDQFGHQEPGDAEEIARFCSLDYPVSFPLMAKCEVNGEQAHPFYRWLKQQKPGLLGSEAIKWNFTKFLLDREGRVVDRFAPQTKPEDLAGAIQGLL
>NZ_CP050994.1|WP_168235179.1|1622118_1623519_+|DEAD/DEAH-box-helicase
MSFNELGLSPHILRAVKELGYEQPTPIQQQAIPAILAGQDVLGGAQTGTGKTAGFTLPMLHRLLANHGRGGRRKVRALVLTPTRELAAQVGESIIKYAHHLPFRTLIAYGGVSIKPNLDAIKLGVDILVATPGRLLDLLTQGALTLSSLEVLVLDEADRMLDMGFITDIRRIMKALPDERQTLLFSATFSNDIKALADDLLNDPTLIEVDPSNTAADQVTQRVIQVDRERRREMLSHMIGRGNWQRVLVFVRTKQIADRLAQQMQKDGLNTVAIHGDKSQGARNRALADFREGKVRVLVATDIAARGLDIDQLPHVINFELPQMAEDYIHRIGRTGRAGRGGEAISLVSQDELGQLKDIEALIGQSLTVEILEGYEPSGKPSRQTLPGSKPVQNPPRDRGHANAKSNNAKGKPDAAKGKGKAKGDGPKKPAPARKREVVGEDIGFTPMRRLPKAQRDDYQDNSSEE
>NZ_CP050994.1|WP_168235180.1|1623593_1624034_-|acetyltransferase
MKIEQADAGDYQALIAPWEASVRATHHFLQEADITALKPLILEHYFAAVDLVCARGEEGEIAGFCGVHDGNIEMLFIAPEARGSGVGRLLVAHAIQRQGARRVDVNEQNAQALGFYQHLGFEVTGRSPLDGQGKPYPLLHMALAAE
>NZ_CP050994.1|WP_168236542.1|1624092_1624554_-|GNAT-family-N-acetyltransferase
MVVIRECREEDLAGLLSLYAELRPRDPVLAPSVAREALRRLLAEPGVRLLVAEVEGQLAATCQLGVIPTLSNGGRPFAIIEHVVTASAFRRRGLSQQLLAQALTLAWELDCYKVMLLSGEGREGAHRLYEKLGFKAGIEKGFVIKQAEARATP
>NZ_CP050994.1|WP_168236543.1|1624589_1624922_-|YnfA-family-protein
MLEFKTIGLFLITALAEIVGCYLPYLWLTQGRSVWLLLPAGLSLALFAWLLSLHPTAAGRVYAAYGGVYIFVAILWLWAVDGIRPTVWDWVGSGVALTGMAIIMFAPRSA
>NZ_CP050994.1|WP_168235181.1|1625056_1625902_-|hypothetical-protein
MQITELSNFIGLGVAGNFAGHLEQAGEAADFVAVKVADKVAPKALFPFYVPGHPGQLGVFPLSGEAIFLPEAAVSGDEKVQIEPEVALWCELEYAGEQVVAIHPKAFGAYNDCSIRRPNARKISEKKNWGEESKGLAATLLPLSHFAPGCELDDYRIACYLERDGELHGYGVDSAAVDYSYFHQQLLDWAIDKFNHQQDEGPAEHIQGLLAQAGRPAHALISIGATRYTPFGETHFLSPGDTSCVVVYPASRYGEADIREAIRARTFGPDVSALLQAVRVR
>NZ_CP050994.1|WP_168235182.1|1626172_1626745_+|class-IV-adenylate-cyclase
MTTHFQGRFEVEFKYRLTDSAAFLRALEALGPELMVADNHEQDCYFDTADSALAREQKSLVIRTMAPSGIRLWIVKGPGPDRCEAVNITDADKAISMVRTLGYQRVLTIAKRRSIYFLGPFHLTLDSLAGIGDFAELAIMTDEEAALPAYREQLLALAARLGLCPEMRETRSYRTLCEQSAHLLQEESAP
>NZ_CP050994.1|WP_168235183.1|1626741_1627134_+|NUDIX-domain-containing-protein
MIDKLAWLTFKEGKLLCARSHGKALYYIPGGKREPSESDEAALVREIAEELAVSLKPETLHLACEFSAQADGKPQGVQVRLRCYTGEADGSPTASAEIAELRWLDSSHLNEVSPVSRLLFQWLAEQGLIR
>NZ_CP050994.1|WP_168235184.1|1627249_1627756_+|GNAT-family-N-acetyltransferase
MEILEVDSTRGIKPALITLLQDCVASGASVGFLPPLPEELGLEYWQGIEADLADGVRRLWVAFDQHHLVGALQLSLCTKANGGHRAEVEKLMVHSQARGKGVGRALMNAMEQGARDAKRTLLVLDSRVGDVASTLYRQLGYQEAGQIPDFARNADGTLAATQFFYKQL

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Crispr_ID: NZ_CP050994_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_7

1774903-1774976

Orphan

Consensus_repeat	Method
AACAAGATCATGCATATGCTCTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_7

>merge|NZ_CP050994|7|1774903-1774976|CRISPRCasFinder
AACAAGATCATGCATATGCTCTAGCGGTGTTATTCCATCGCCAGCATCAATAACAAGTTCATGCATATGCTCTA

>NZ_CP050994|7|7|1774903-1774976|CRISPRCasFinder
AACAAGATCATGCATATGCTCTA	GCGGTGTTATTCCATCGCCAGCATCAAT
AACAAGTTCATGCATATGCTCTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_168235245.1\|1767513_1768239_-\|oxygen-insensitive-NADPH-nitroreductase	unknown	unknown	gnl\|CDD\|182710
NZ_CP050994.1\|WP_168235251.1\|1781564_1782287_+\|TPM-domain-containing-protein	unknown	unknown	gnl\|CDD\|224429
NZ_CP050994.1\|WP_042650272.1\|1766589_1767354_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_111913393.1\|1780977_1781568_+\|LemA-family-protein	unknown	unknown	gnl\|CDD\|224618
NZ_CP050994.1\|WP_106886607.1\|1763136_1763730_+\|GTP-cyclohydrolase-II	unknown	unknown	gnl\|CDD\|234745
NZ_CP050994.1\|WP_025327205.1\|1777418_1777826_-\|transcriptional-regulator	unknown	unknown	unknown
NZ_CP050994.1\|WP_168235249.1\|1778004_1778904_+\|aldo/keto-reductase-family-oxidoreductase	unknown	unknown	gnl\|CDD\|227322
NZ_CP050994.1\|WP_111913365.1\|1772133_1772835_+\|DUF2982-domain-containing-protein	unknown	unknown	gnl\|CDD\|378593
NZ_CP050994.1\|WP_106886596.1\|1780176_1780920_+\|penicillin-insensitive-murein-endopeptidase	unknown	unknown	gnl\|CDD\|236511
NZ_CP050994.1\|WP_042650274.1\|1768306_1769869_-\|AbgT-family-transporter	unknown	unknown	gnl\|CDD\|225525
NZ_CP050994.1\|WP_042650276.1\|1775036_1775468_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|312075
NZ_CP050994.1\|WP_168235243.1\|1764807_1766028_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340882
NZ_CP050994.1\|WP_168235242.1\|1763802_1764714_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP050994.1\|WP_168235250.1\|1779470_1780013_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_168235248.1\|1776637_1777345_-\|short-chain-dehydrogenase	unknown	unknown	gnl\|CDD\|181609
NZ_CP050994.1\|WP_168235247.1\|1775534_1776551_-\|low-specificity-L-threonine-aldolase	unknown	unknown	gnl\|CDD\|178323
NZ_CP050994.1\|WP_081805676.1\|1778980_1779259_-\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|240845
NZ_CP050994.1\|WP_111913367.1\|1772912_1773857_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP050994.1\|WP_168235244.1\|1766041_1766596_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|368781
NZ_CP050994.1\|WP_168236546.1\|1769954_1771964_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|236645

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_168235245.1\|1767513_1768239_-\|oxygen-insensitive-NADPH-nitroreductase	gnl\|CDD\|182710	PRK10765, PRK10765, oxygen-insensitive NADPH nitroreductase.	2.76934e-157
NZ_CP050994.1\|WP_168235251.1\|1781564_1782287_+\|TPM-domain-containing-protein	gnl\|CDD\|224429	COG1512, COG1512, Beta-propeller domains of methanol dehydrogenase type [General function prediction only].	1.52643e-60
NZ_CP050994.1\|WP_081805676.1\|1778980_1779259_-\|RNA-binding-protein	gnl\|CDD\|240845	cd12399, RRM_HP0827_like, RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins. This subfamily corresponds to the RRM of H. pylori HP0827, a putative ssDNA-binding protein 12rnp2 precursor, containing one RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain). The ssDNA binding may be important in activation of HP0827. .	2.66511e-36
NZ_CP050994.1\|WP_106886607.1\|1763136_1763730_+\|GTP-cyclohydrolase-II	gnl\|CDD\|234745	PRK00393, ribA, GTP cyclohydrolase II RibA.	1.03789e-136
NZ_CP050994.1\|WP_168235249.1\|1778004_1778904_+\|aldo/keto-reductase-family-oxidoreductase	gnl\|CDD\|227322	COG4989, COG4989, Predicted oxidoreductase [General function prediction only].	3.88837e-170
NZ_CP050994.1\|WP_111913365.1\|1772133_1772835_+\|DUF2982-domain-containing-protein	gnl\|CDD\|378593	pfam11201, DUF2982, Protein of unknown function (DUF2982). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	3.52147e-70
NZ_CP050994.1\|WP_106886596.1\|1780176_1780920_+\|penicillin-insensitive-murein-endopeptidase	gnl\|CDD\|236511	PRK09429, mepA, penicillin-insensitive murein endopeptidase; Reviewed.	1.95925e-126
NZ_CP050994.1\|WP_042650274.1\|1768306_1769869_-\|AbgT-family-transporter	gnl\|CDD\|225525	COG2978, AbgT, Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism].	0
NZ_CP050994.1\|WP_042650276.1\|1775036_1775468_+\|PAS-domain-containing-protein	gnl\|CDD\|312075	pfam08448, PAS_4, PAS fold. The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.	0.000143922
NZ_CP050994.1\|WP_168235243.1\|1764807_1766028_+\|MFS-transporter	gnl\|CDD\|340882	cd17324, MFS_NepI_like, Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily. This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.48691e-60
NZ_CP050994.1\|WP_168235242.1\|1763802_1764714_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	6.29785e-50
NZ_CP050994.1\|WP_168235248.1\|1776637_1777345_-\|short-chain-dehydrogenase	gnl\|CDD\|181609	PRK09009, PRK09009, SDR family oxidoreductase.	3.37648e-33
NZ_CP050994.1\|WP_168235247.1\|1775534_1776551_-\|low-specificity-L-threonine-aldolase	gnl\|CDD\|178323	PLN02721, PLN02721, threonine aldolase.	3.41646e-145
NZ_CP050994.1\|WP_111913393.1\|1780977_1781568_+\|LemA-family-protein	gnl\|CDD\|224618	COG1704, LemA, Uncharacterized conserved protein [Function unknown].	6.49068e-82
NZ_CP050994.1\|WP_111913367.1\|1772912_1773857_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.21399e-43
NZ_CP050994.1\|WP_168235244.1\|1766041_1766596_-\|VOC-family-protein	gnl\|CDD\|368781	pfam06185, YecM, YecM protein. This family consists of several bacterial YecM proteins of unknown function.	1.88918e-24
NZ_CP050994.1\|WP_168236546.1\|1769954_1771964_-\|EAL-domain-containing-protein	gnl\|CDD\|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	3.05126e-104

>NZ_CP050994.1|WP_111913367.1|1772912_1773857_+|LysR-family-transcriptional-regulator
MKYIEEFYLFVKVVQEGGFSHAAAALGMPTGTISRRISQLEEQLGCALLHRSTRKLRLTDEGLRYYERLCTPLAEIEQATGEIQGQERDISGLIRLAAPIALSNTILVDMLADFGLRYPGVQFDISQTNDHAPLCDQDRDLVFFNGELSQTLPNALCLGHIEYGLFASPLYLEKMGIPSHPAQLEEHDLIYCWPHQHWQLSGRDQQTVQIKRTPRLNVNQTQAAVRAARRHLGIVNAPLHYVHPFLQDEQLVAVLPDWQSGKRPFYMLHCQPQFTPLRVKMFADFVEKYSARYRHHQRDDQFLPAMPLPVASDG
>NZ_CP050994.1|WP_111913365.1|1772133_1772835_+|DUF2982-domain-containing-protein
MKTLHVIPMVRRNGLTLVLLGMVITIAMIFILFFFPEQLLMPVIFLLLTGLMTILVGALKLAEPHFSLSLCQDCLQYHHKYGGWILKWRNIQRIDQPRIHLGWDLVPLPYIGLKIKDYDDFLTLITPRLAVRLLTEQRAVLLQAISSERPDCLTGGCGSGLLGEGLLEESRFRSPSGQQYDGVIAMLGNRMARLRDLLGYDLLVPDNSLDRPPADFVHLLNQYQRESNLIQIN
>NZ_CP050994.1|WP_168236546.1|1769954_1771964_-|EAL-domain-containing-protein
MDVLHTPIWVYDIQRHHIYWANGSALGLWEASSLAELQSRDFSADMAAAIDLLLQRYLGDFQQDRSYNEWWTLSPKGVKKQVYLRLSGIQLAGRQMMMTEAVIDADTLYQESSLATGDTLACLFDNEGALESGNHHFDMCFGTGITRLAQVFSGDDEAFYTRLSRVGEAVAEGECRTQKGMRWFQYQFRHIQQGARILLTMRDITDRKLEELEHRHLAWHDSLTGLLNRYGLMKSLEAYCGLGGRFALVFMDLDNFKLVNDNYGHKAGDRLLERVAGRLKQICPRDVELARLGGDEFTALVPLSQASERAQEVADLMLSQMSKPLQLSGVPEVTIGGSIGIAIYPDDADDGDNLITRADMAMYQAKQMGRLRWQRFTPSMQQSLHRKLTLKQFLAKAVGRGELSLRYQPQVDVAQGKLIGLEALLRWYNPVLGHVSPAEFIPLAEEMGLIREIGSWVLSTALAQMGEWQRQWQVRVPVSVNLSGFQLSASLPGQVAQQLRESEVEAGLLTLELTETVLMLDMKGCIEILDALSEQGIKIAIDDFGTGYSSLAYLNRLPIDTIKLDRSFVVGLNLPVIRATVAMATSLGLGILAEGVEDEHELAALRAQGCHVFQGFLFSPPHDPGGGGGGRLRDPVQAWSLSADRRLSPPLTMCGMSHFRSATCQIKHN
>NZ_CP050994.1|WP_042650274.1|1768306_1769869_-|AbgT-family-transporter
MSQAAVNERPASPNGWLNRFLNGVEKAGNKLPDPAMLFLYALLIVWVGSWIGSQFSFDLVNPRTGEAVVVNNLLTGAGLAEFLASMVTTFTGFAPLGIVLVAMLGVGVAEQSGFINTGLKKLLKVTPARFLTPMLILVAIVSHTAADAGYVLVIPIGGIIFHAAGRHPLAGIAAAFAGVSGGFAANFLPSGGDALLQGFTQSAAQLLDPDYMVNTLCNIIFTGASSLLIICVGWFVTEKIVEPRLKQVPLNEDLESADEMGRYSAQESRAFNWAGFAMLAAVVLLGLALSPDDSPMRAPDGSLTTFAAPVMKSIVPLIFLLFILPGIVYGFVAGSFKSGKDVIDAMSATMNKMGSYMVMAFFCALFIKAFGDSNLGTLLALSGAEVLHALALPGEVTIVGMILLTASVNLVVGSASAKWALISPILVPMLMAVGISPELTQAAYRVGDSASNIITPLMVFFPLVVVYCQQYVKSTGIGTLVSMMLPYSLAFLVSWTCFLLLYWALGFPLGLQAPYVYPAP
>NZ_CP050994.1|WP_168235245.1|1767513_1768239_-|oxygen-insensitive-NADPH-nitroreductase
MNPTIDLILSHRSIRQFTPEPISASQLDQILSAAQSASSSSFLQANSLIRVTDKGLRATLAELAGHQAYVAEAAEFLLFCADYQRHGQIVPEAQTGFVEQLMIGAIDGALMAQNALLAAQSLGLGGVYIGGIRNNPAAVSELLGLPHQVIPLFGLCLGHPAQQPEQKPRLPRALVVHENRYPETLDRALLAQYDSQIHDYYLARSSNNKVQTWSGQIKAILGKEARPFMLGFLQSKGFCLK
>NZ_CP050994.1|WP_042650272.1|1766589_1767354_-|hypothetical-protein
MILTLILLSIGALLFLVIAYNVVQQYKQKAEADKRQAIARHKAVADETEEVLLNVNLVPFSKNMVLLLQHRILDAYRAIVQVMPNPQVKQRIIDVQTQIKNVQENYSSQDEGHFKTPESDRQAIQMLQLAKKMRAVLRVEHNKGKIDPQGFAQEDRRLELMQLKINIANLIKRAMDAQIQGQYGTCRQLYTKGLGALANVSDKDPYLLAREEDMRQGMRQLEEHLQQHSEKELQNIKDKEADELDVLFQPKKKW
>NZ_CP050994.1|WP_168235244.1|1766041_1766596_-|VOC-family-protein
MVIMSHPLDTTLGPMAPFVCQLLTEMHALMGECDAPVVDHLCYRAATLPEYLALKETLARHGVLLVEGMIGGRPIATYRLHQPVCWQQVTVPCIELAAPKAGRAHQAGLEHIELVVPSLPALVAAHSGLAFKTANMGDGRNPDVGLMLPSGQIKFHLRPLSEVIDEELHTGAVVPVPADYYDSL
>NZ_CP050994.1|WP_168235243.1|1764807_1766028_+|MFS-transporter
MIEVGSREWIRATLALSLGSFLVFLNLYQTHPLLPLLAQVFSVSSLSAGWTLAGCTAGLAGSLLICARLADRFGRRRIMLWTLTCAILLSLCIPWVTRFDLLVCLRILQGALLAGLPATAIAYMGEEFSKRALLSAVGVYIAANSLGGIAGRVVGGLLAGWFGDWQHTFLGIGLISLALLPLVIWLLPAQTRFVAVEAAPGQLRSAIQSHLGNPLLLGAYLIGGLNFMVFLNQYSYLTFLLAKAPFSLPTQWLGMLFLTYLTGTLASSLSGRCAHRWGAQRLLLAGIALMALGSLALLQGTLAAIIGGLLVSSFGFFLAHACASAWVGQHVEHNRALASSLYLVGYYLGASLGGLYLHPFWERGGLWGLVLGIELVLCVTAALSLWLGHLKGRVAPPLSSHAPSRQ
>NZ_CP050994.1|WP_168235242.1|1763802_1764714_-|LysR-family-transcriptional-regulator
MDLKQLGYLLAVRDTGSFTKAAQVLHVAQPAVSMAIAKLEQQLELRLFDRQDRSVRLTPEGEVLCRHAERLLLQMHQAEAEMAELKGLERGEVRIGIPYMMGSYYFPPILMAFKHSYPGLKIRVEEAGTRELLSRMVDGSLDLAILITSDLPPALEGAQLLREEMLMVVGEEHPLRGASAVSLPQFFSQELAMFRRGFYHREHMEALAQGLGIEPNIGFESNLIPLLKAVVRQGFAVTTFLRMVLEEETALCGIPFAPPIFLDLCVAWRRGDPLSMANRALRDFLLAQANPESAPDGALMDNQ
>NZ_CP050994.1|WP_106886607.1|1763136_1763730_+|GTP-cyclohydrolase-II
MSSISLVAKSKLPTPWGTFTLVGFQETGTGKDHAALVMGDIADGEPVLGRIHSECLTGDALFSLRCDCGFQLQAAMEKIAKAGRGVLLYVRQEGRGIGLLNKIRAYHLQDQGADTVEANVALGFAADMRDYTICADMLKALEVKSLRLMTNNPRKLKAMESFGIPVAERVPLQEGRNPHNEFYLSTKANKLDHLFKK
>NZ_CP050994.1|WP_042650276.1|1775036_1775468_+|PAS-domain-containing-protein
MEIREFHWLMNIVQNLDVGLVVLDKGYRVQVWNGFMESHSGRLAGEVRDQVLFDLFPDVDRAWLERKANMVFKLNNRAFSTWEQRPYLLRFSNYRPITGSAPHMYQNLTLVPLADFGGEVTHLAIMIYDATDEAMLITGQRQG
>NZ_CP050994.1|WP_168235247.1|1775534_1776551_-|low-specificity-L-threonine-aldolase
MRYIDLRSDTVTQPTEAMRQSMLHAEVGDDVYGEDPSINALEHKGAELLGKEAALFVPSGTMSNLLAMMSHCQRGEGAVLGSASHIYRYEAQGSAVLGSVALQSVPMQADGTLALSDVRAAIAPDDAHFVQTRLVCLENTHNGKVLPLHYLREMRDFVDEHGLLLHLDGARLFNAVAASGEPVAAIAAPFDSISVCLSKGLGAPVGSLLVGSHGFIARARRLRKMLGGGMRQGGILAQAALFALDQHVTRLADDHRRARRLAEGLAPLPGIALNMEEVQTNMVFLRLTRGDPATLLGFMKERGILFSGYGELRLVTHLQITDDDIDEVIDAFTEFLNG
>NZ_CP050994.1|WP_168235248.1|1776637_1777345_-|short-chain-dehydrogenase
MSYLILGSGGLGGALAHELASRGEEWLLAGRQLPKGLDPACYFPLQEVDPLSFEALFTLYDATTLPRVVINTIGLLHDLNHMPERRVEEVSPQWLGESLQANAWPHLALGASLSRLMTPESRLWLCSLSDLAGSLGTGNLEAVGRYSYRMSKAALNMGARILAAEWAERFPGAGVITVHPGLMDTPMQQPFRQGLDPALLQDPALVAPQLLDLLASLTLAHSGRFVDLRGQPLPW
>NZ_CP050994.1|WP_025327205.1|1777418_1777826_-|transcriptional-regulator
MEGFAARLQSLIGEGSVSAFARKVGLSEALIRKYLKGAEPGLGKANQIAMGANCSLEWLATGCGYLYRQAEVVDRDALAAAGALVQEKLPGQPLPDEQHLVTLLAYYQFLRSHKQADGFLDLARAREFGRHLAEA
>NZ_CP050994.1|WP_168235249.1|1778004_1778904_+|aldo/keto-reductase-family-oxidoreductase
MSVSRLALHHQGPTFSRLIMGYWRLMEWQLSPAALLDLMKYHLDLGVTTIDHADIYGGYQCEEAFGQALRLEPSLRSRMELVSKCGIALTAKPEHALNHYNTSKDHIVASAEASLQKLGTDHLDLLLIHRPDPMMNADEVAEAFISLKQAGKIKHAGVSNFTPHQFALLQSRLPFPLVTNQLEISPLHQEGTLDGALDQCQQLGIKPMAWSCLGGGRLFNDPAYAPLRAELEQIRHEVGAQHIEQVVYAWVMMLPSQPLPLIGSGKRERIAAAVAAESIQLNRQQWFRIRKAALGYDVP
>NZ_CP050994.1|WP_081805676.1|1778980_1779259_-|RNA-binding-protein
MKIYVGNLSYRMTADELTNVFSQFGQVDKVDIIIDRDTGQSKGFGFIEMPVNGDAEKAIAELHGTEIGGRTITVNQAKPKTDAPRGRPQRHR
>NZ_CP050994.1|WP_168235250.1|1779470_1780013_-|hypothetical-protein
MRVSELASRGGVNWLMPPARRFYGVMICLLLASLGTVVAALLLGYPEMGLLPWVGLVFGGIVLVMMVLPRNWQRWRLAELAWDDHHLYLLNGGEDRALALPRAALVGIERDRKVGHDGQWLDFSLDLGLDGETLADATALLGLTREGTHEVAPSVYRFGFKRAWHSRRALSSLLAVLQPV
>NZ_CP050994.1|WP_106886596.1|1780176_1780920_+|penicillin-insensitive-murein-endopeptidase
MFATALLFTTSALYAEAIGGYAAGCLKNGVSLPLTGPGYQVIRTKRLRYYGHPDLIHYLQGLANQTRLAGMPDLYIADLAMARGGPFTSGHRSHQTGLDADIWFRMANRPISKWEQDAPKEWALIDEPSYKMLPGRFGPQQLNLLRLAASKPEVARIFVNPVIKAEVCKRAADEPWVAKLRPWVGHFSHFHVRLRCPANSPDCQPQAPIPPGNGCDAELASWLKDKPQLPKVSMSYRAPVLPRRCEG
>NZ_CP050994.1|WP_111913393.1|1780977_1781568_+|LemA-family-protein
MATSLRHRATQCLLTFTLLLGLTGCGMNNIPTLDEQVKASWGQVENQYQRRADLIPNLVATVKGYASHEQETLKAVTDARARVGSVQVSDPSQLKTFEAAQDQLSSALSRLMVVVERYPDLKADQQFLTLQAQLEGTENRIAVARRDYIEAVRQFNTEIRTFPGVIWSKLLYSDLEAKPSFSAKPGADEAPKVSFQ
>NZ_CP050994.1|WP_168235251.1|1781564_1782287_+|TPM-domain-containing-protein
MTMMLRALLPLLLLWTAALQAAPVFPTLSGRVVDEAALMSRKQAHQLTQQLAAFEKRSGIQLVVVSVDNLDGETIEEYGYQLGRHWGIGQKGKNNGVLLLIAQDERKVRIEVGYGLEGALPDAIAANIIQTRILPAFKRGDMVAGVVAGSQSIMKALAGEYQPVEQPKSDSDGGPWLFILVVIAMIVLHNLRGGGGGPGGRRRAAYMAGGFGAGSFGGRSGGGFRGGGGSFGGGGASGGW

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Crispr_ID: NZ_CP050994_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_8

2007898-2008057

Orphan

Consensus_repeat	Method
CAATAAGGCATCTGCCATGGTCGGCGTGATCACCAACGATCTATCTTCCGCCCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_8

>merge|NZ_CP050994|8|2007898-2008057|CRISPRCasFinder
CAATAAGGCATCTGCCATGGTCGGCGTGATCACCAACGATCTATCTTCCGCCCACCACCGCGGCGCTGATGTGGTATTGATTGGCACGCCAGAGGGCGTAGTCACGCAATAAGGCATCTGCCATGGTCGGCGTGGTCACCAACGATCTATCTTCCGCCCA

>NZ_CP050994|8|8|2007898-2008057|CRISPRCasFinder
CAATAAGGCATCTGCCATGGTCGGCGTGATCACCAACGATCTATCTTCCGCCCA	CCACCGCGGCGCTGATGTGGTATTGATTGGCACGCCAGAGGGCGTAGTCACG
CAATAAGGCATCTGCCATGGTCGGCGTGGTCACCAACGATCTATCTTCCGCCCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_168235350.1\|2016068_2017340_+\|glucose-1-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|234824
NZ_CP050994.1\|WP_168235345.1\|2005002_2006349_+\|Na+/H+-antiporter-NhaC-family-protein	unknown	unknown	gnl\|CDD\|224671
NZ_CP050994.1\|WP_025327397.1\|2008362_2009595_+\|phosphoglycerate-dehydrogenase	unknown	unknown	gnl\|CDD\|236985
NZ_CP050994.1\|WP_163153789.1\|2006482_2007079_+\|5-formyltetrahydrofolate-cyclo-ligase	unknown	unknown	gnl\|CDD\|182385
NZ_CP050994.1\|WP_168235341.1\|1994514_1995420_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NZ_CP050994.1\|WP_106886451.1\|2002063_2003200_-\|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|237139
NZ_CP050994.1\|WP_168235343.1\|1997710_1998673_-\|IS1595-family-transposase	unknown	unknown	gnl\|CDD\|372298
NZ_CP050994.1\|WP_168235348.1\|2012269_2013277_-\|vitamin-B12-ABC-transporter-permease-BtuC	unknown	unknown	gnl\|CDD\|235159
NZ_CP050994.1\|WP_168235340.1\|1993202_1994372_-\|DUF1615-domain-containing-protein	unknown	unknown	gnl\|CDD\|369501
NZ_CP050994.1\|WP_168235344.1\|1998822_2002047_-\|carbamoyl-phosphate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|235393
NZ_CP050994.1\|WP_106886448.1\|2009805_2010186_-\|diacylglycerol-kinase	unknown	unknown	gnl\|CDD\|260133
NZ_CP050994.1\|WP_139751447.1\|2017443_2017686_-\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|370243
NZ_CP050994.1\|WP_163137947.1\|2003868_2004681_-\|4-hydroxy-tetrahydrodipicolinate-reductase	unknown	unknown	gnl\|CDD\|234595
NZ_CP050994.1\|WP_168235349.1\|2013363_2014113_-\|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|366132
NZ_CP050994.1\|WP_010675200.1\|2014225_2014582_+\|DMT-family-protein	unknown	unknown	gnl\|CDD\|377316
NZ_CP050994.1\|WP_106886447.1\|2010327_2011392_+\|3-deoxy-7-phosphoheptulonate-synthase	unknown	unknown	gnl\|CDD\|183726
NZ_CP050994.1\|WP_168235342.1\|1995690_1997349_-\|2-isopropylmalate-synthase	unknown	unknown	gnl\|CDD\|235154
NZ_CP050994.1\|WP_106886444.1\|2014637_2015777_+\|PilT/PilU-family-type-4a-pilus-ATPase	unknown	unknown	gnl\|CDD\|227341
NZ_CP050994.1\|WP_168235339.1\|1992894_1993134_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_168235347.1\|2011497_2012283_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|235150

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_168235350.1\|2016068_2017340_+\|glucose-1-phosphate-adenylyltransferase	gnl\|CDD\|234824	PRK00725, glgC, glucose-1-phosphate adenylyltransferase; Provisional.	0
NZ_CP050994.1\|WP_168235345.1\|2005002_2006349_+\|Na+/H+-antiporter-NhaC-family-protein	gnl\|CDD\|224671	COG1757, NhaC, Na+/H+ antiporter [Energy production and conversion].	8.05919e-77
NZ_CP050994.1\|WP_025327397.1\|2008362_2009595_+\|phosphoglycerate-dehydrogenase	gnl\|CDD\|236985	PRK11790, PRK11790, phosphoglycerate dehydrogenase.	0
NZ_CP050994.1\|WP_163153789.1\|2006482_2007079_+\|5-formyltetrahydrofolate-cyclo-ligase	gnl\|CDD\|182385	PRK10333, PRK10333, 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional.	5.37796e-68
NZ_CP050994.1\|WP_168235341.1\|1994514_1995420_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	9.69993e-54
NZ_CP050994.1\|WP_106886451.1\|2002063_2003200_-\|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	gnl\|CDD\|237139	PRK12564, PRK12564, carbamoyl-phosphate synthase small subunit.	0
NZ_CP050994.1\|WP_168235343.1\|1997710_1998673_-\|IS1595-family-transposase	gnl\|CDD\|372298	pfam12762, DDE_Tnp_IS1595, ISXO2-like transposase domain. This domain probably functions as an integrase that is found in a wide variety of transposases, including ISXO2.	2.09714e-13
NZ_CP050994.1\|WP_168235348.1\|2012269_2013277_-\|vitamin-B12-ABC-transporter-permease-BtuC	gnl\|CDD\|235159	PRK03784, PRK03784, vtamin B12-transporter permease; Provisional.	2.04879e-141
NZ_CP050994.1\|WP_168235340.1\|1993202_1994372_-\|DUF1615-domain-containing-protein	gnl\|CDD\|369501	pfam07759, DUF1615, Protein of unknown function (DUF1615). This is a family of proteins of unknown function expressed by various bacterial species. Some members of this family are thought to be lipoproteins. Another member of this family is thought to be involved in photosynthesis.	0
NZ_CP050994.1\|WP_168235344.1\|1998822_2002047_-\|carbamoyl-phosphate-synthase-large-subunit	gnl\|CDD\|235393	PRK05294, carB, carbamoyl-phosphate synthase large subunit.	0
NZ_CP050994.1\|WP_106886448.1\|2009805_2010186_-\|diacylglycerol-kinase	gnl\|CDD\|260133	cd14264, DAGK_IM, Integral membrane diacylglycerol kinase. This mostly bacterial family of homo-trimeric integral membrane enzymes, the products of the dgkA gene, catalyzes the ATP-dependent phosphorylation of diacylglycerol to phosphatidic acid. Escherichia coli DAGK participates in the membrane-derived oligosaccharide cycle (MDO cycle) by recycling lipids to restore phosphatidylglycerols that were used up in the biosynthesis of MDOs. DAGK also recycles diacylglycerols that are produced during the biosynthesis of lipopolysaccharides (LPS) back to phospholipids. DAGK is not the main source of phosphatidic acid in de-novo biosynthesis of glycerophospholipids. Escherichia coli DAGK has low activity as an undecaprenol kinase.	2.62054e-50
NZ_CP050994.1\|WP_139751447.1\|2017443_2017686_-\|LuxR-family-transcriptional-regulator	gnl\|CDD\|370243	pfam09012, FeoC, FeoC like transcriptional regulator. This family contains several transcriptional regulators, including FeoC, which contain a HTH motif. FeoC acts as a [Fe-S] dependant transcriptional repressor.	1.82253e-22
NZ_CP050994.1\|WP_163137947.1\|2003868_2004681_-\|4-hydroxy-tetrahydrodipicolinate-reductase	gnl\|CDD\|234595	PRK00048, PRK00048, dihydrodipicolinate reductase; Provisional.	1.95366e-139
NZ_CP050994.1\|WP_168235349.1\|2013363_2014113_-\|amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|366132	pfam00497, SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3.	4.04297e-26
NZ_CP050994.1\|WP_010675200.1\|2014225_2014582_+\|DMT-family-protein	gnl\|CDD\|377316	pfam04342, DMT_6, Putative member of DMT superfamily (DUF486). This family contains several proteins of uncharacterized function. The family is represented in the Transport classification database as 2.A.7.34, though the exact nature of what is transported is not known.	2.68815e-61
NZ_CP050994.1\|WP_106886447.1\|2010327_2011392_+\|3-deoxy-7-phosphoheptulonate-synthase	gnl\|CDD\|183726	PRK12756, PRK12756, Trp-sensitive 3-deoxy-7-phosphoheptulonate synthase AroH.	0
NZ_CP050994.1\|WP_168235342.1\|1995690_1997349_-\|2-isopropylmalate-synthase	gnl\|CDD\|235154	PRK03739, PRK03739, 2-isopropylmalate synthase; Validated.	0
NZ_CP050994.1\|WP_106886444.1\|2014637_2015777_+\|PilT/PilU-family-type-4a-pilus-ATPase	gnl\|CDD\|227341	COG5008, PilU, Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion].	3.15512e-178
NZ_CP050994.1\|WP_168235347.1\|2011497_2012283_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|235150	PRK03695, PRK03695, vitamin B12-transporter ATPase; Provisional.	8.13337e-68

>NZ_CP050994.1|WP_163153789.1|2006482_2007079_+|5-formyltetrahydrofolate-cyclo-ligase
MPDTQPERQSLRQLIRQRRKSLSQAEQQAAAQQLVTRFQEHPEIQGARRIALYLANDGELDPLPAIHWLWSQRKEVYLPVLHPFTPGHLLFLRYTATSPMTRNRYGIAEPELDVQQVLPHSMLDLICTPLVAFDAEGNRLGMGGGYYDRTLACWHEHGLGPRPLGLAHDCQQVESVPQAQWDVPLPQIITPARCWRFS
>NZ_CP050994.1|WP_168235345.1|2005002_2006349_+|Na+/H+-antiporter-NhaC-family-protein
MIQTQPSARALLPLLVFLALFIGTGTWLTLQGVEFAFYQLPAPVAALPAVMLALMLGKEGFNKNLETFFKGVGDSNIMAMCLIYLLAGAFATVAKATGGVDATVALGLSLIPGWFLLPGLFLISAFIATAMGTSMGTIGAVAPVALGVAQATGIDPVLMAGTILSGAMFGDNLSIISDTTIAATRSQGCEMKDKFRENVKIAAPAAVLVILLYLLLGSTGDAPTATASADLLKVMPYLLILVLALGGMNVFVVLGLGILTAGGVGMIGGYPLGQFSKDIYQGFTSMQEIFLLSMLIGGLGALMERQGGLAWISARIAALIARFTRHHDGEQNEKAAELGIAGVVGLTNLCTANNTVAIIVASKVARDLAEHHGVTPRRAASMLDIFSCVVQGLIPWGAQALLLGSIFALSPLAVVSMSFYPMALGLAAIIAVFVKHQLRTAAEPSPQS
>NZ_CP050994.1|WP_163137947.1|2003868_2004681_-|4-hydroxy-tetrahydrodipicolinate-reductase
MDNPIRVAVMGCNGRMGKVLLEAITNAEGVVVGAALERPGSAVIGLDAGELNGLGRLGVIISDSLDKVRDEFDLIIDFTRPEVTLANLAFALAHGKQMVIGTTGFDEAGKAALQEAGKQIGIVFASNYSVGVNLVFKLLEQAAKVMGDYTDIEIIEGHHRHKVDAPSGTALSMGEVVAKTLGRDLKECAVYGREGITGERDRNTIGFATIRAGDLVGEHTVMFADIGERVEISHKASSRLTFANGAVRAGKWLGQQGAGLYDMQDVLDLK
>NZ_CP050994.1|WP_106886451.1|2002063_2003200_-|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit
MNHTALLVLEDGTVFKGVSIGAEGCSVGEVVFNTSMTGYQEILTDPSYSRQIVTLTYPHIGNTGTNSEDEESSQIHAQGLIIRDLPILASNFRNQQSLSDYLKSHNIVGIADIDTRKLTRILREKGAQAGCILAGKQLDEAHALSQARAFPGLKGMDLAKEVTVSDAYAWTEGSWQLGKGHVTPAADELKYHVVAYDFGVKRNILRMLVDRGCRLTVVPAKTPAAEVLAMNPDGIFLSNGPGDPEPCDYAIEAIKTFLGTNTPVFGICLGHQLLGLASGAKTVKMKFGHHGANHPVKSLDDNTVMITAQNHGFAVDENSLPECLRATHVSLFDGSLQGIHRTDRPAFSFQGHPEASPGPHDCAGLFDHFIELIKQYRA
>NZ_CP050994.1|WP_168235344.1|1998822_2002047_-|carbamoyl-phosphate-synthase-large-subunit
MPKRNDLQSILILGAGPIVIGQACEFDYSGAQACKALREEGYRVILVNSNPATIMTDPEMADATYIEPITWEVVREIIKKERPDAVLPTMGGQTALNCALDLEKHGVLAEFGVEMIGATADAIDKAEDRRRFDIAMKSIGLECPRAGIAHNMEEAWGVQQMVGFPCIIRPSFTMGGSGGGIAYNTEEFVEICERGLDLSPTKELLIDESLIGWKEYEMEVVRDRNDNCIIVCAIENFDPMGIHTGDSITVAPAQTLTDKEYQLMRNASMAVLREIGVETGGSNVQFGINPKDGRMVIIEMNPRVSRSSALASKATGFPIAKIAAKLAIGYTLDELMNDITGGRTPASFEPAIDYVVTKIPRFNFEKFAGANDRLTTQMKSVGEVMAIGRNFQESLHKALRSLETGKTGFDPMVDLNAPDSLTRIRHELQDAGCDRIWYIADAFRAGLSMDGIFKLTKIDPWFLVQIEELVKLEEEVKERGMAGLDADFLRALKRKGFADARLAKILGVAEGEVRKARARHNIFPVYKRVDTCAAEFATNTAYMYSSYDEECEAAPTNRDKIMIIGGGPNRIGQGIEFDYCCVHAALALREDGYETIMVNCNPETVSTDYDTSDRLYFEPVTLEDVLEIVRVEQPKGVIVQYGGQTPLKLARALEANGVPVIGTSPDAIDRAEDRERFQSAVERLGLKQPENGTVTALEQAVQVAARITYPLVVRPSYVLGGRAMEIVYDEQDLRRYFAEAVSVSNESPVLLDRFLDDATEVDVDAICDGVDVVIGGIMEHIEQAGIHSGDSACSLPPHTLSKAIQDEMREQVRKLALELGVVGLMNVQFAVKDNEIYLIEVNPRAARTVPFVSKATGAPLAKIAARVMAGQSLQDQGFTTEIIPPYYSVKEVVLPFAKFPGVDPLLGPEMRSTGEVMGVGSSFAEAYAKAQLGAGHQVPSEGRALLSVRHGDKERVVNLAAKLLELGYDLDATHGTAVTLGEASINPRLVNKVHEGRPHILDRIKNGEYTYIVNTAEGRQAIQDSKQLRRGALQHKVAYTTTLHAAFATCMAISVDATANVNSVQELHHKVKHR
>NZ_CP050994.1|WP_168235343.1|1997710_1998673_-|IS1595-family-transposase
MDTQAFQHLLSLFPLLTLRQRRLAQHELTAPHPITSLATQLPPCQCCPHCQAEAAQLAPWGWSRGLRRYRCKQCLRTSSVLTKTPLARLRKAQCWEDYAQALIDGLTVRQAAVRCGVCKNTAFLWRHRFLKAMASHQAVREEGIVEVDETFFLESFKGQRGLPRPARHRGGKGRTRGTGSDYIPVMVVQDRAGHHADFQLEKMNAETVIAVLTPLVSPDAVLCSDGAGVYASFSKAQGVTHQVVRNRQGKRVIGAYHIQHVNGYHRRLKEWMERFHGVATHYLRNYLGWRRMLERYGREVNIPRCLQEALGRPMQHVIGT
>NZ_CP050994.1|WP_168235342.1|1995690_1997349_-|2-isopropylmalate-synthase
MSFDHRKYRPAPVIALADRQWPNRVMTQAPLWCAVDLRDGNQALVEPMTVAQKLQMWALMTHVGFKHIEVGFPAASQPDFDFVRELIERNLIPDDVTIQVLVQAREDLIARTFDSLKGAKRAIVHVYNSVNPTQRNYVFNTDREGVKGIAVQGARWVREYAARNPGTEWSFQYSPESFSSTEVEFAVEVCDAVIDEWRTASRPMILNLPATVEVSTPNVFADQVEWFCRHLKARPEVSISIHTHNDRGCGVAAAELAVLAGADRIEGTLLGNGERTGNMDIVTMAMNLYSQGIDPELDLSDMDAIVATVGACTQIALHPRHPYAGELVYTAFSGSHQDAIRKSLAAEKPDPYWDVAYLPIDPADLGRSYEAVIRINSQSGKGGVTYLLERDLGLQLPRWLQIDFSRRVQAEAEASSSEISPEQIRALFEQHYLEPLHGYRIGRFQLGHDSQETLRLELQTPDGSLQLCGEGEGAITALVNGWERQTGMHIDVLDYSEHALCAGTESRAAAYVLLSVDGVRMCGVAIGRDVVNASLQAVINGAAQIRALRQSA
>NZ_CP050994.1|WP_168235341.1|1994514_1995420_-|GGDEF-domain-containing-protein
MMKTPLRLSVHPARFFSLSPGRRLALLSLLCLLLLTGGLDAASFERLPEHNLYTIGALAEAINVLTLLFMFWVVQCAQISNRTYLFLCAGLGSWLVSGTIDLVDEAYFQPWWLSTVEDSLRTLGMLATAWGVLLMVQQMYGVQTRLASLAMSDELTGLSNRRAFRAVLEAHLDQGTPLLLLDLDHFKQINDRYGHGIGDNVLQEFSALLCQHCPPDGVVARLGGEEFAIWLPGMLSDKAQALAEQIRAATEALIACEEIRFTVSIAVGIGQAGEAVEALVKRTDLALYRAKHLGRNRVELA
>NZ_CP050994.1|WP_168235340.1|1993202_1994372_-|DUF1615-domain-containing-protein
MIPSRPLSFSPWRLCALLAAAVLAGCASEPTPPTPTVEEAAAIAKQPKAMQPRKPADMKSRIVRFLPRQVPDKPGWANDVVTALSTQGLTVNDHNVCSVLAVAEQEATYQADPVVPGLGKIAWKEINARAAKLLIPEFVVRTALSIKSPTGKSYAARIDALRTEREMSEIFEDMIGAVPMGKQLFGNLNPVRTGGPMQVSVAFAEANARGYPYPVKESIRHEVFTRRGGIWFGTKHIFGYPADYPDTLYRFADFNAGWYASRNAAFQAAVSRVSGKPLALDGDLVRYDSDLPGKTELAVHSIASRVNMSKQAIHQSLLKGDSSDFAQTDLYHRVFTLADKQAGKRQPRAVLPGIQLKSPKITRNLTTAWFAKRVDDREQACVRKMATIR
>NZ_CP050994.1|WP_168235339.1|1992894_1993134_+|hypothetical-protein
MNIKKTSVIAAVASMSMLVASCASDPQPTWKKEGVSHDDTLTAFSQCKYEIRLNNISDEEKNAVITDCMQAKGFRWRAY
>NZ_CP050994.1|WP_025327397.1|2008362_2009595_+|phosphoglycerate-dehydrogenase
MTAKFSLDKDKIKVLLLEGVHPNTVETFRAAGYTNVEYLKTSLSEEELIERIRDVHFVGLRSRTQITEKVLDAAGKLVAIGCFCIGTNQVSLDAAHVRGIPVFNAPFSNTRSVAELVLGEILLLLRGIPEKNAKCHRGVWEKLANRSVEARGKKLGIIGYGHIGTQLGIIAEMIGMKVYYYDIENKLSLGNAIQVPNLVELLNMSDVISLHVPETASTKDLIGAEQLRMMKPGAIFINASRGTVVDIDALADVIKSGHLSGAAIDVFPSEPKSNDEEFLTPLRGLDNVILTPHIGGSTQEAQENIGLEVANKLVKYSDNGSTLSAVNFPEVSLPGHKGSSRLLHIHRNQPGVMNQINQIFADEGINIAGQYLQTSSEIGYVVIDVETEHSEKALSRLKEINGTIRARILH
>NZ_CP050994.1|WP_106886448.1|2009805_2010186_-|diacylglycerol-kinase
MAKPGATGVTRIINATGYSMKGLKSAWINEAAFRQELVLVLALMPLAGWLGDSLNEILLLICISWLVVIVEVLNSAIEAVVDRIGSEHHELSGRAKDLGSAAVFIALALNALVWGALIGRNLLGWW
>NZ_CP050994.1|WP_106886447.1|2010327_2011392_+|3-deoxy-7-phosphoheptulonate-synthase
MSIHTDELRTRRLESLITPSELAHAFPLNDTVAQNLLDARHDVEAILAGEDQRLLVIVGPCSIHDPAAAREYAQRLNTLREQYKESLCIVMRTYFEKPRTIVGWKGLINDPRLDGSFDVNEGLKLARQLLVDINEMGMPTATEFLDMVTGQYISDLITWGAIGARTTESQVHREMASALSCPVGFKNGTDGNTRIAIDAVRAARHSHIFYSPDKDGKMTIYRTAGNPYGHVILRGGHRPNYDTASIDEACEALADVGLPERLVVDFSHGNSMKDHRRQLLVAQDICDQLRRGRTGIAGIMAESFLVEGRQDVENGCAVTFGQSITDACLSWEDTETLLAMLAEAAQVRLDKQKA
>NZ_CP050994.1|WP_168235347.1|2011497_2012283_-|ATP-binding-cassette-domain-containing-protein
MSPVNSSPNPLWLLEARALGIPARLAPLDLAWAGGQLVALLGPNGSGKSTLLGALAGILPAEGAVLLGGEVLTDLSWPELARRRAMLPQRQPQLFHIPVFQVLSLGLEEGGLPESQGRAVAEICAALELDALLARDFSRLSGGEQQRVLIARTLLQLWPGLNTDGRVLLLDEPLAGLDLHHQLALLRLLKRLSRQGLLVVIAIHDINLAIDWADRILCLQQGRVVSEGGVDVIDEALLERVFQIRTDRIEAGGRVWFMPSL
>NZ_CP050994.1|WP_168235348.1|2012269_2013277_-|vitamin-B12-ABC-transporter-permease-BtuC
MYLALIHRQQRWQRHWLLALSLLVLSLFLLSLALGEFVLLPWQPLGELELRILLDLRLPRALLALLAGAALACGGAVLQVMLHNPVAEPGLLGVSSGAGLAAMVAMAVAKSLGVYLPGWGLSLAAFGGALVVTMLLIHLARRARLGHTRLLLFGVAIGILTNAAMTWLMYFADDGSLREFMFWMMGSLSYGSQQLGWWWLVLPLTLGWLCWQGRALQQLLLGETQARLMGMNVDRMRVRLVLAVCLLTGVAVSLCGVIGFVGLVVPHLLRLCGGSDQRFLLPASALGGGALLLGADLVARSALQAGELPIGVITASVGAPLFIYLLLRQDADVSR
>NZ_CP050994.1|WP_168235349.1|2013363_2014113_-|amino-acid-ABC-transporter-substrate-binding-protein
MGKTSWGVLCLLFACMAPVTAMANGAPTLTVVTDVWPPFRMLAQNDEFHGLDIDILRQLQARSGIALTLKRVPWGRALKQMQTGQADLMIGLAHTPERAAFIDYLQPAYYQCRPAFYGKAAAVATLKTYEDLRGREIGYVLNSAYFAPFDDDGQLDKHGVPTEDQLQRMVERGHLPLMIGTDCQVDYALSQRNDAGLIKADYRPPHPVVLYLGMSKHSPHHDLGPALAQALQTMVESGEIEALAKPYQP
>NZ_CP050994.1|WP_010675200.1|2014225_2014582_+|DMT-family-protein
MNPIMTSIGLLICSNVFMTFAWYAHLKSMNHKPWIIAALVSWGIALFEYLLQVPANRIGHTVLSVGQLKILQEVITLTVFVPFSIFYLKEDLKWDYLWAGLCILGAVFFVFREKLTGA
>NZ_CP050994.1|WP_106886444.1|2014637_2015777_+|PilT/PilU-family-type-4a-pilus-ATPase
MELRDMLQILAKQDGSDLYLSTGAPPCAKFNGALRPLNEVPLEPGEVARIAAELMDSEQKQQFEKELEMNLAISLPQIGRFRVNIFKQRNEVSLVARNIKTEIPRFEDLKLPPVLLDTIMEKRGLVLFVGGTGSGKSTSLAALIDHRNRNSGGHIITIEDPVEFVHRHRKSIINQREVGVDTRSFHAALKNTLRQAPDVILIGEIRDRETMEHALAFSETGHLAISTLHANNANQALDRIINFFPEERRPQLLNDLGNNLKAFVSQRLVKTTDGGRRAAVEVMLGTHTIRDLIKRGEFGGLKEIMEKSRALGMVTFDSTLFDLVVEGVIDEEEAVKNADSQNNLRLKIKLWREKGQIGNSAAASGWSLEPTKDDNNDLF
>NZ_CP050994.1|WP_168235350.1|2016068_2017340_+|glucose-1-phosphate-adenylyltransferase
MLLQPANTARSRQLLNETMALVLAGGRGSRLQQLTDSRAKPAVHFGGKFRIIDFVLSNCINSGIRRIGVVTQYKSHSLLRHLQSGWSFLRYQMNEFIELLPAQQRIDEVSWYRGTADAVYQNMDIIREHGPKYVVVLAGDHIYKMDYAAMLLDHVNLGSRVTVACIEVPRQEASAFGVMAVDESRKINAFVEKPADPPAMPGKPDTALASMGVYIFDADYLYQLLEEDLANEQSHHDFGMDVIPRVVKEGTAYAHPFSLSCVGCCPQKRPYWRDVGTVDSFWEANMDLASVTPELDIYDQDWPIWTSQKMTAPAKFVQDQNGQHGMTINSLFAGGTIVSGSFIVSSVLFNNVRVDSFCTLDQAVIFPGVEIGAGCRLRRVVIDKGCRLPEGLVVGENACEDARRFYRSEQGIVLVTQEMLASL
>NZ_CP050994.1|WP_139751447.1|2017443_2017686_-|LuxR-family-transcriptional-regulator
MILRELGDYLAAQQKVSRRDLARHFHTSEDAVEAMLGVWMRKGRVTKRETRVCGGSCCGKSEEVMFEWCEPGRIGLVQQR

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Crispr_ID: NZ_CP050994_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_9

2047445-2047579

Orphan

Consensus_repeat	Method
CCATCTCCCTCACCCTTCCTCAAAGGGAAATGACGGATTATTGCCCT	CRISPRCasFinder

1 spacers

DinG

The CRISPR arrays of NZ_CP050994_9

>merge|NZ_CP050994|9|2047445-2047579|CRISPRCasFinder
CCATCTCCCTCACCCTTCCTCAAAGGGAAATGACGGATTATTGCCCTGGCCAAAGCGCAGGATTACACCAGGCGTTGCCATAGCCTGGCCATCTCCCTCACCCTTCCTCAAAGGAAAATGACGGATTATTGCCCT

>NZ_CP050994|9|9|2047445-2047579|CRISPRCasFinder
CCATCTCCCTCACCCTTCCTCAAAGGGAAATGACGGATTATTGCCCT	GGCCAAAGCGCAGGATTACACCAGGCGTTGCCATAGCCTGG
CCATCTCCCTCACCCTTCCTCAAAGGAAAATGACGGATTATTGCCCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_163147247.1\|2038892_2039102_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_168235368.1\|2050457_2050952_+\|DUF2062-domain-containing-protein	unknown	unknown	gnl\|CDD\|378263
NZ_CP050994.1\|WP_168235366.1\|2044602_2045598_-\|tetraacyldisaccharide-4'-kinase	unknown	unknown	gnl\|CDD\|234808
NZ_CP050994.1\|WP_005331987.1\|2044248_2044449_-\|Trm112-family-protein	unknown	unknown	gnl\|CDD\|225391
NZ_CP050994.1\|WP_025327477.1\|2042647_2043292_-\|UvrY/SirA/GacA-family-response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|236538
NZ_CP050994.1\|WP_106886404.1\|2049945_2050464_+\|DUF2062-domain-containing-protein	unknown	unknown	gnl\|CDD\|378263
NZ_CP050994.1\|WP_168235365.1\|2043502_2044252_-\|3-deoxy-manno-octulosonate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|235473
NZ_CP050994.1\|WP_168235373.1\|2056579_2058667_+\|ATP-dependent-DNA-helicase-DinG	DinG	COG1199_DinG_CAS-IV-A	gnl\|CDD\|236966
NZ_CP050994.1\|WP_168235374.1\|2058811_2059471_+\|DUF2057-domain-containing-protein	unknown	unknown	gnl\|CDD\|378258
NZ_CP050994.1\|WP_168235372.1\|2055135_2056194_-\|porin	unknown	unknown	gnl\|CDD\|225744
NZ_CP050994.1\|WP_139436951.1\|2039818_2040373_-\|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	unknown	unknown	gnl\|CDD\|182763
NZ_CP050994.1\|WP_168235376.1\|2060599_2061748_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|179614
NZ_CP050994.1\|WP_168235370.1\|2052656_2053847_-\|aspartate/tyrosine/aromatic-aminotransferase	unknown	unknown	gnl\|CDD\|181731
NZ_CP050994.1\|WP_168235375.1\|2059543_2060440_+\|histone-deacetylase	unknown	unknown	gnl\|CDD\|212519
NZ_CP050994.1\|WP_168235363.1\|2038528_2038690_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_168235369.1\|2051078_2052584_+\|DUF853-family-protein	unknown	unknown	gnl\|CDD\|283518
NZ_CP050994.1\|WP_163135033.1\|2038106_2038256_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_168235371.1\|2053993_2054935_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_168235364.1\|2040666_2042520_-\|excinuclease-ABC-subunit-UvrC	unknown	unknown	gnl\|CDD\|234792
NZ_CP050994.1\|WP_168235367.1\|2045597_2047367_-\|lipid-A-ABC-transporter-ATP-binding-protein/permease-MsbA	unknown	unknown	gnl\|CDD\|183016

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_168235375.1\|2059543_2060440_+\|histone-deacetylase	gnl\|CDD\|212519	cd09993, HDAC_classIV, Histone deacetylase class IV also known as histone deacetylase 11. Class IV histone deacetylases (HDAC11; EC 3.5.1.98) are predicted Zn-dependent enzymes. This class includes animal HDAC11, plant HDA2 and related bacterial deacetylases. Enzymes in this subfamily participate in regulation of a number of different processes through protein modification (deacetylation). They catalyze hydrolysis of N(6)-acetyl-lysine of histones (or other proteins) to yield a deacetylated proteins. Histone deacetylases often act as members of large multi-protein complexes such as mSin3A or SMRT/N-CoR. Human HDAC11 does not associate with them but can interact with HDAC6 in vivo. It has been suggested that HDAC11 and HDAC6 may use non-histone proteins as their substrates and play a role other than to directly modulate chromatin structure. In normal tissues, expression of HDAC11 is limited to kidney, heart, brain, skeletal muscle and testis, suggesting that its function might be tissue-specific. In mammals, HDAC11 proteins are known to be involved in progression of various tumors. HDAC11 plays an essential role in regulating OX40 ligand (OX40L) expression in Hodgkin lymphoma (HL); selective inhibition of HDAC11 expression significantly up-regulates OX40L and induces apoptosis in HL cell lines. Thus, inhibition of HDAC11 could be a therapeutic drug option for antitumor immune response in HL patients.	1.71462e-133
NZ_CP050994.1\|WP_168235368.1\|2050457_2050952_+\|DUF2062-domain-containing-protein	gnl\|CDD\|378263	pfam09835, DUF2062, Uncharacterized protein conserved in bacteria (DUF2062). This domain, found in various prokaryotic proteins, has no known function.	1.93298e-27
NZ_CP050994.1\|WP_005331987.1\|2044248_2044449_-\|Trm112-family-protein	gnl\|CDD\|225391	COG2835, COG2835, Uncharacterized conserved protein [Function unknown].	2.27803e-17
NZ_CP050994.1\|WP_025327477.1\|2042647_2043292_-\|UvrY/SirA/GacA-family-response-regulator-transcription-factor	gnl\|CDD\|236538	PRK09483, PRK09483, response regulator; Provisional.	1.10462e-164
NZ_CP050994.1\|WP_168235370.1\|2052656_2053847_-\|aspartate/tyrosine/aromatic-aminotransferase	gnl\|CDD\|181731	PRK09257, PRK09257, aromatic amino acid transaminase.	0
NZ_CP050994.1\|WP_168235365.1\|2043502_2044252_-\|3-deoxy-manno-octulosonate-cytidylyltransferase	gnl\|CDD\|235473	PRK05450, PRK05450, 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional.	3.97469e-157
NZ_CP050994.1\|WP_168235373.1\|2056579_2058667_+\|ATP-dependent-DNA-helicase-DinG	gnl\|CDD\|236966	PRK11747, dinG, ATP-dependent DNA helicase DinG; Provisional.	0
NZ_CP050994.1\|WP_168235374.1\|2058811_2059471_+\|DUF2057-domain-containing-protein	gnl\|CDD\|378258	pfam09829, DUF2057, Uncharacterized protein conserved in bacteria (DUF2057). This domain, found in various prokaryotic proteins, has no known function.	1.95786e-49
NZ_CP050994.1\|WP_168235372.1\|2055135_2056194_-\|porin	gnl\|CDD\|225744	COG3203, OmpC, Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane].	2.28246e-37
NZ_CP050994.1\|WP_106886404.1\|2049945_2050464_+\|DUF2062-domain-containing-protein	gnl\|CDD\|378263	pfam09835, DUF2062, Uncharacterized protein conserved in bacteria (DUF2062). This domain, found in various prokaryotic proteins, has no known function.	1.9465e-47
NZ_CP050994.1\|WP_168235376.1\|2060599_2061748_-\|MFS-transporter	gnl\|CDD\|179614	PRK03633, PRK03633, putative MFS family transporter protein; Provisional.	0
NZ_CP050994.1\|WP_168235369.1\|2051078_2052584_+\|DUF853-family-protein	gnl\|CDD\|283518	pfam05872, DUF853, Bacterial protein of unknown function (DUF853). This family consists of several bacterial proteins of unknown function. BMEI1370 is thought to be an ATPase.	0
NZ_CP050994.1\|WP_139436951.1\|2039818_2040373_-\|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	gnl\|CDD\|182763	PRK10832, PRK10832, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase.	2.29498e-83
NZ_CP050994.1\|WP_168235366.1\|2044602_2045598_-\|tetraacyldisaccharide-4'-kinase	gnl\|CDD\|234808	PRK00652, lpxK, tetraacyldisaccharide 4'-kinase; Reviewed.	2.15685e-168
NZ_CP050994.1\|WP_168235364.1\|2040666_2042520_-\|excinuclease-ABC-subunit-UvrC	gnl\|CDD\|234792	PRK00558, uvrC, excinuclease ABC subunit UvrC.	0
NZ_CP050994.1\|WP_168235367.1\|2045597_2047367_-\|lipid-A-ABC-transporter-ATP-binding-protein/permease-MsbA	gnl\|CDD\|183016	PRK11176, PRK11176, lipid A ABC transporter ATP-binding protein/permease MsbA.	0

>NZ_CP050994.1|WP_168235367.1|2045597_2047367_-|lipid-A-ABC-transporter-ATP-binding-protein/permease-MsbA
MQQETSQESWPVFKRLLGYVRDRKLGLVGGIIGMLGYAAVDTTFVYSIKPLIDQGLNGNDSSVLKWMPFFVLGIVALRGCAAFLSNYCMAWVGNHVVMRLQQQVFSHLMAMPMSFFDRQNTGNLLSKVTYDAGQVSSAASSTLVSLVREGATVIGLLGLMFWHSWQLSVIFLVVGPVVGVLIGLISRRFRKISRHIQQAVGDITTSTEQMLKGHKEVLMFGGQQVEDKRFFTVSNRMRQQTMKMVAADAIGSPIVQMVASVALAVFLYVATIDSVKATLTAGTFTVMVTSMMMLLKPLKSLTDVNNQFQRGITACQSLFGLLDSTPEQDTGTRTLERARGEIEFRNVTFTYPTKDTPALHNISFKVEAGKSVALVGRSGSGKSTIASLLTRFYDIEQGEILLDGVNIREYKLSELRKQYALVSQHVHLFNDSVANNIAYAAEDKYSREEIQHAARIAHADEFVRKMPEGYDTVIGENGASLSGGQRQRIAIARALLRDSPVLLLDEATSALDTESERHIQAAIDELCKARTSLVIAHRLSTIEKADEILVIDEGHIVERGNHDALMAQQGTYAQLRAIQFGNVAVSNKG
>NZ_CP050994.1|WP_168235366.1|2044602_2045598_-|tetraacyldisaccharide-4'-kinase
MLERLWYGKSGWRWALAPLALLFALVSGGRRFAYRRGWFTRYRASLPVIVVGNISVGGNGKTPVVVWLVEQLQARGWRPGVVSRGYGGKAPHYPYRLDATSTTAQAGDEPVLIARRCGCPVVVAPKRADAVRLLEQSGEVDIIITDDGLQHYALARDIELVVVDGARRFGNGCLLPMGPLREPMTRLKRVDAIICNGGTPALGEYPMALVAAAPRRVCDDAPLEAPLAGPVDALAGIGHPPRFFATLTGLGYELVQSAGYADHQAFDRDELLARFGERPLLMTEKDAVKCRAFAPAHWWYLPVSAELPASLLDTLLQRLTPPQAPGHERSY
>NZ_CP050994.1|WP_005331987.1|2044248_2044449_-|Trm112-family-protein
MALDIKLLDIIACPVCKGKLHYQPQSDKAAHELICRFDRLAYPLEEGIPVLLENRARHLPLEELKP
>NZ_CP050994.1|WP_168235365.1|2043502_2044252_-|3-deoxy-manno-octulosonate-cytidylyltransferase
MSFVVVIPARYASTRLPGKPLADIHGKPMVQHVVEKALQSGADRVIVATDDERVQQALQTTGVEVCMTSKDHQSGTERLAEVCRHYGFAADTIVVNVQGDEPLIPPAIIRQVADNLAAATAPMATLSVPIQDAEEAFNPNAVKVVTDKDGYALYFSRASIPWDRDRFAKSREQIGSHYQRHIGIYAYRAGFIQRYVDWAPSALEQVEALEQLRVLWYGEKIHVAQALEAPPVGVDTQQDLDKVRALLAH
>NZ_CP050994.1|WP_025327477.1|2042647_2043292_-|UvrY/SirA/GacA-family-response-regulator-transcription-factor
MINVFLVDDHELVRTGIRRILEDVRGIKVVGEAQSGETAVAFCRQHHPDVILMDMNMPGIGGLEATRKILRLRPDVRIIVLTIHSENPFPTKVMQAGAAGYLTKGAAPDEMIHAIRLVHSGQRYISPEIAQQMALSQFASADENPFKSLSERELQIMMMITKGQKVTDISEQLNLSPKTVNSYRYRLFSKLGINGDVELTHLAIRYGMLDADTL
>NZ_CP050994.1|WP_168235364.1|2040666_2042520_-|excinuclease-ABC-subunit-UvrC
MTLSPEPLFDSKAFLSAVTHQSGVYRMYDGGGTVIYVGKAKDLKKRLASYFRTNVDSIKTRTLVRQIADIQVTVTHTETEALILEHNLIKQYQPRYNVLLRDDKSYPWIIITAHLHPRIGVHRGARKVKGEYFGPYPSGGAVRESLHLMQKIFPVRQCEDAVYANRTRPCLLYQLKRCAGPCVAGLVSEAEYAQQVELAKLFLAGKNQQVIGELVGKMESASGDLRFEEAARYRDQIQALRRVTEQQSVSGNVLDELDVVGVAFDQGAACIHVLFIRQGKVLGSRSYFPKVPADTPLDEVVQSFLLQFYLSGQGGRQIPSEVLLDVALEDEAVIAETLSQTAGYKVRVQSRTRSERARFIKLASINAQTALRSRLAHKSTITARYDQLEELLELERPIARMECFDISHTMGERTVASCVVFNREGPLSSEYRRFNIDGITGGDDYAAMEQALERRFGKQQEPDKVPDVLFIDGGLGQLRRAEEILARQLEFLGGKYPLLVGIAKGVTRKAGLETLIMGESHEELHLPADMPALHLIQHIRDESHRFAITGHRARRAKARTTSTLEDIPGVGPKRRQALLKYLGGLQEVKKAGVDELAKVPGISQELAQSIHDALHSL
>NZ_CP050994.1|WP_139436951.1|2039818_2040373_-|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase
MTNIPNLLTFFRILLIPVFVILFYLPYQWSYLAAALVFILAAATDWFDGYLARKLNQSTAFGAFLDPVADKIMVAAALVVIVEHYNTIWVTIPAMTMIGREIIISALREWMAELGKRSSVAVSWIGKWKTMIQMVSLTGLIWQYDIWMVWLAYVLLYVATVLTFWSMFQYMKAAWGDLTYHSRF
>NZ_CP050994.1|WP_163147247.1|2038892_2039102_+|hypothetical-protein
MTENARERLKMLITHSGKSLEECGHDGVLEELVEDSTLFGSDHNEILCVLEAWSGSSRRTQLLGFLFDE
>NZ_CP050994.1|WP_168235363.1|2038528_2038690_+|hypothetical-protein
MDIAKYQSKTAVVIFIRLFPLFDFIGEFPDRWRNNWLISCSLVATEKHNHPNR
>NZ_CP050994.1|WP_163135033.1|2038106_2038256_+|hypothetical-protein
MKIWKICLIAAQLMLVACASSDGSGPPPTGDDGSNAGGKSGGGSSYLTY
>NZ_CP050994.1|WP_106886404.1|2049945_2050464_+|DUF2062-domain-containing-protein
MPKRLIKRWLPDQDKLKEHKHLRLFGKLLLDANLWHLNRRSAAGAFAVGLFMAWIPLPCQMLLAAGGAILFRVNLPLSVALVWLSNPFTMPPLFYGAYLVGCQLLGHPAQHIDIQFTWEWLVSVFETLAPPLLLGSLVLALLSALMGYAFIRTFWRINTVRQWQKRKEARAC
>NZ_CP050994.1|WP_168235368.1|2050457_2050952_+|DUF2062-domain-containing-protein
MLSRWLARLKIDPDTLRQQKWFALFGERLLTPALWQGGTRALSGAVAAGLFASWIPIPMHSLVAVGLALAFSLNLPLALLAVWFNNPLTLPFMYLYAYRTGCLVLHQTPEPFHLTWSLHWLEHEAATLVPPFLLGSLLLAVLTAATGALLTLLMLQLGRLTAAR
>NZ_CP050994.1|WP_168235369.1|2051078_2052584_+|DUF853-family-protein
MAQPLTLAYANGQPISLLPAMANRHGLITGATGTGKTVTLQVLAEGFSRLGVPVFLADVKGDLSGLGAAGTPSSKLDARLAQLGIPAPAFAPSPTLFWDLFAEQGHPVRATVSDMGPLLLARLLGLNDTQSGVLELVFKVADDEGLLLLDLKDLRAMVQFAGDNAKSLTTRYGNVSTASIGAILRNLLTLESAGGDHFFGEPMLDIQDLLQTDGAGHGHINVLAAGKLTQSSRLYACFLLWLLSELFEQLPEVGDPDKPVLVFFFDEAHLLFNDAPKALLEKIELVVRLIRSKGVGVYFVTQSPADIPDSVLGQLGNRVQHALRAFTPSDQKAVRIAANTLRANPAFDAAGVITELGVGEALASLLDEKGRPSVVERAFIAPPASRIGPLSDAERQALIQGSVLHGRYETREDRESAFERLNGGAPAASDDVSQTPSEQGGGLLDALNGILFGRTGPRGGQHDGVVQTAAKSVARTLGNEVGRQLVRGVLGSLLGGSKRRR
>NZ_CP050994.1|WP_168235370.1|2052656_2053847_-|aspartate/tyrosine/aromatic-aminotransferase
MFEKVVAAPADPILGLTEAFRADSRSHKINLGVGIYKDETGATPILHCVKKAEQKLLTDEKTKNYLGIEGNIEYGRIVQQLLFGQDSALIASGRAKTAQAPGGTGALRIAAEFVVRNGLAKTIWISDPTWANHVSVFQAAGLTVKWYKYYDAATKGLDFAAMQASLSEAQAGDLVLLHGCCHNPTGIDPTADQWRALAKQSAAAGWLPLFDFAYQGFARGIEEDAEGLRIFAECHDELLVASSFSKNFGLYNERVGAFTLVSATKEIADVAFTQVKTVIRANYSNPPSHGAAVVTTIVSDPALYAEWVEEVAAMRVRIREMRELLVEKLAALGVSQDFSFIREQNGMFSFSGLSKDQVERLKSEFAIYIVGSGRISVAGITRANIDPLCDAIAKVL
>NZ_CP050994.1|WP_168235371.1|2053993_2054935_-|hypothetical-protein
MIDFSHPEWRALAQQLLDEAPQVIRGRQWQPLIGMLRDNQLLLPLGNHRYELTPAGRRYLTRELMLAELACAPPEPEEWLHAQGWQLGERVNERVLAALYRKGEASFSPVEQINFEDKGIRLCSDLPLRLRAARPFSLFFSGGTLLDAAPWLHTLGEVALPARTLAGLGKILWGEGEIQRVISTDSVGVFAELSLPDDALLVWLPAEDPGALQPLIAALPPQTLWSHLTALDPAGVDRVLVLAQRLGRPASWWLPRDLAPIKEAYAAPLQGARPWEPSRIPRPLRALCSDLVESNRGLSAEVCALASGWHAIG
>NZ_CP050994.1|WP_168235372.1|2055135_2056194_-|porin
MKKTILAIAIPALFASAANAAVVYDKDGTSFDIYGRVQANYYADHNEADDKAPSGYSDVDGELVGSSRLGWSGKVALNNTWSGIAKTEWQVASENSNAGDKEFDARHVYVGFDGTQYGKIIFGQTDTAFYDVLEPTDIFNEWGDVGNFYDGRQEGQVIYSNTYGGFKGKLSYQTNDENAEKISDVGGSIKKTVFTDVKRNYGYAAAAGYDFDFGLGLNAGYAYSDLESKANVDSGDKSEWALGAHYAINGFYFAGMYTQGELNNDTTNFEGKGRGYELAASYNVDAWTFLAGYNFTEAKNNTNQTSYKDQVDETLLGVQYAFTSKFKAYTEYKIQGIDELDDEFTVALQYNF
>NZ_CP050994.1|WP_168235373.1|2056579_2058667_+|ATP-dependent-DNA-helicase-DinG
MLSTRLKATIRNTYRQIADGLPGFVPRKEQNFLVAEIAKTLTGEYEKSRRILVAEAGTGIGKSLSYAQGAIPVARLTQKKLVISTATVALQEQLIHKDLPFYHRHSELPFRFMLVKGRQRYCCEHLLEQAASGADMANFELDFFLQNTGSLSKHKPSDSDKERYQALWQAYTEGKWDGDRDNWPKPIPDLCWDRIAADRHSCNKALSHHQHCPFHRARNDMDAADVLVVNHALLLSDLTMGGGIILPPPDECIYVLDEAHHLPTIARDHGAASASVKGSRRWLEKLVQSAGKLARALNKESLLDPQLKLQDALASLQPDLKALEQWLAGNDQLFGSEQHHRFAEGVLPDPLPMLAENLKEASKKALRALDRMQGAIGEALKDGEIRRKEAEPLLAESGFHLQRLESFCALWEMLSRHVPTGKTPLARWMARSEDGDIWLHASPIEVGYLLEEWLWSRCLGAVLVSATLTALSSFSYFRHQVGLKEHDGTRYLRLRSPFEYHKAELYLPKMTHEPSAPGFTQELVDTLPRLLAGKEASLVLFSSYRQMNEVAVGLRAKGLSLLVQGEASRNALLTLHKQKCDGGQASILFGTGSFSEGLDLPGHYLTNLVITKLPFAVPNSPVEEATAEWVEKRGGNPFLQLTVPEASRKLIQACGRLIRKEADRGRVTILDRRLLTKRYGKGLLDALPPFTRRIE
>NZ_CP050994.1|WP_168235374.1|2058811_2059471_+|DUF2057-domain-containing-protein
MKLTVLVPALAGLLWAGSALADSQLEIQNPYVVQLIDGESINPKLLEKTSSFPISAGKHQLVVAFEGNYSNRNDIKLVTAEPLVINFTAADNQTLVLDFKKPRNEDEAKAFVKEQKVVLKDKVSGQALASEQFVMPKVGGFQLTRDYQQELLKMGKAFNQPATVAVSTAAVMAAASAPVEVAPSKAQSNPEALTQLQNWYNKADAETRKAFQIWVIQQQ
>NZ_CP050994.1|WP_168235375.1|2059543_2060440_+|histone-deacetylase
MSLRIFYHPHYSSLTLPERHRFPLAKYQALYQILATQGYPLAEAPAASREQITRVHDADYVAAALVGTLDDGAIRRLGFPWSPMLIERTLRSVGATIAASRHALEQGCGLQVSGGYHHAHRDFGSGFCLFNDLVIAARACLDEGRCERVLIVDLDVHQGDGSAALCTGSRDIITLSLHGEHNFPHHKPASHLDFALPSGMQDDAYLETLTQALSLALRLYRPDLILYQAGVDVHQADELGYLSLSDAGVRQRDAMVFDCAISHGLPIAAVPGGGYRRDWRQLIPLHLSLFEEAKKRYG
>NZ_CP050994.1|WP_168235376.1|2060599_2061748_-|MFS-transporter
MTTYSRPVPLLLCGLLLLTLAIAVLNTLVPLWLAHDKLPTWQVGMVGSAYFCGNLLGTLLAGALIKHAGFNRSYYLASALFAAACVGLGLTLGFWSWLIWRFIAGIGCAMIWVVVESALMCSGNARNRGRLLAAYMMVYYMGTVLGQLLVSTLPTGLMDVLPWVTGLVLAAILPLLFTRIVNEQGEQQGATRVWPMLRLRQARLGVNGCIISGIVLGSLYGLMPLYLNHQGVSDAGIGYWMAVMVSAGILGQWPAGRLADRFGRLPVLRLQVLVVILGALAMFGNLAMGPALFILGAAGFTLYPVAMAWACEKVEQHQLVAMNQALLLSYTIGSLLGPAYTSLLMQHLSDKLLFIMIASVSFIYLLMLLRPVGEHPTPVAHA

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Crispr_ID: NZ_CP050994_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_10

2083218-2083322

Orphan

Consensus_repeat	Method
ATGCCTTAGCCGTTGAACCGACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_10

>merge|NZ_CP050994|10|2083218-2083322|CRISPRCasFinder
ATGCCTTAGCCGTTGAACCGACCGGTAATCTGTTTATTGATGCTCATCTTGTTCATACCAATAACCCTTGTTGCACCAACCATGCCTTAGCCGTTGAACCAACCG

>NZ_CP050994|10|10|2083218-2083322|CRISPRCasFinder
ATGCCTTAGCCGTTGAACCGACCG	GTAATCTGTTTATTGATGCTCATCTTGTTCATACCAATAACCCTTGTTGCACCAACC
ATGCCTTAGCCGTTGAACCAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_025327511.1\|2082481_2083192_-\|phosphate-signaling-complex-protein-PhoU	unknown	unknown	gnl\|CDD\|182974
NZ_CP050994.1\|WP_168235388.1\|2090063_2090249_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_168235385.1\|2080407_2080950_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_163135110.1\|2075437_2076181_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP050994.1\|WP_111910109.1\|2092244_2093558_+\|isocitrate-lyase	unknown	unknown	gnl\|CDD\|237893
NZ_CP050994.1\|WP_168235387.1\|2088968_2089130_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|182786
NZ_CP050994.1\|WP_163135409.1\|2074388_2075348_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223836
NZ_CP050994.1\|WP_163135108.1\|2071912_2073040_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_CP050994.1\|WP_163135114.1\|2079229_2080132_-\|homocysteine-S-methyltransferase-family-protein	unknown	unknown	gnl\|CDD\|376828
NZ_CP050994.1\|WP_111910105.1\|2085990_2088228_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|226956
NZ_CP050994.1\|WP_163135121.1\|2089720_2089861_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_106886380.1\|2084289_2085939_-\|phosphate-ABC-transporter-permease-PstA	unknown	unknown	gnl\|CDD\|227318
NZ_CP050994.1\|WP_106886381.1\|2080969_2082289_-\|HlyC/CorC-family-transporter	unknown	unknown	gnl\|CDD\|224173
NZ_CP050994.1\|WP_162520047.1\|2093668_2094370_-\|DnaA-inactivator-Hda	unknown	unknown	gnl\|CDD\|181224
NZ_CP050994.1\|WP_005328825.1\|2083363_2084182_-\|phosphate-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|184582
NZ_CP050994.1\|WP_163135112.1\|2076908_2077748_+\|sterol-desaturase-family-protein	unknown	unknown	gnl\|CDD\|225546
NZ_CP050994.1\|WP_168235384.1\|2077819_2079220_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|129983
NZ_CP050994.1\|WP_168235389.1\|2090564_2092172_+\|malate-synthase-A	unknown	unknown	gnl\|CDD\|236432
NZ_CP050994.1\|WP_168235386.1\|2088432_2088972_-\|tRNA-adenosine(34)-deaminase-TadA	unknown	unknown	gnl\|CDD\|182786
NZ_CP050994.1\|WP_168235383.1\|2073503_2074292_+\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270347

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_025327511.1\|2082481_2083192_-\|phosphate-signaling-complex-protein-PhoU	gnl\|CDD\|182974	PRK11115, PRK11115, phosphate signaling complex protein PhoU.	7.56791e-161
NZ_CP050994.1\|WP_111910109.1\|2092244_2093558_+\|isocitrate-lyase	gnl\|CDD\|237893	PRK15063, PRK15063, isocitrate lyase; Provisional.	0
NZ_CP050994.1\|WP_163135110.1\|2075437_2076181_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	1.99989e-153
NZ_CP050994.1\|WP_162520047.1\|2093668_2094370_-\|DnaA-inactivator-Hda	gnl\|CDD\|181224	PRK08084, PRK08084, DnaA inactivator Hda.	1.05495e-110
NZ_CP050994.1\|WP_168235387.1\|2088968_2089130_-\|hypothetical-protein	gnl\|CDD\|182786	PRK10860, PRK10860, tRNA-specific adenosine deaminase; Provisional.	0.00140457
NZ_CP050994.1\|WP_163135409.1\|2074388_2075348_+\|ABC-transporter-permease-subunit	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	3.67358e-88
NZ_CP050994.1\|WP_163135108.1\|2071912_2073040_-\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	5.17758e-51
NZ_CP050994.1\|WP_163135114.1\|2079229_2080132_-\|homocysteine-S-methyltransferase-family-protein	gnl\|CDD\|376828	pfam02574, S-methyl_trans, Homocysteine S-methyltransferase. This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases also known EC:2.1.1.13; Betaine--homocysteine S-methyltransferase (vitamin B12 dependent), EC:2.1.1.5; and Homocysteine S-methyltransferase, EC:2.1.1.10,.	7.32966e-73
NZ_CP050994.1\|WP_111910105.1\|2085990_2088228_-\|ABC-transporter-permease-subunit	gnl\|CDD\|226956	COG4590, COG4590, ABC-type uncharacterized transport system, permease component [General function prediction only].	0
NZ_CP050994.1\|WP_106886380.1\|2084289_2085939_-\|phosphate-ABC-transporter-permease-PstA	gnl\|CDD\|227318	COG4985, COG4985, ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism].	1.9928e-93
NZ_CP050994.1\|WP_106886381.1\|2080969_2082289_-\|HlyC/CorC-family-transporter	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	6.50811e-134
NZ_CP050994.1\|WP_005328825.1\|2083363_2084182_-\|phosphate-ABC-transporter-ATP-binding-protein	gnl\|CDD\|184582	PRK14236, PRK14236, phosphate transporter ATP-binding protein; Provisional.	0
NZ_CP050994.1\|WP_163135112.1\|2076908_2077748_+\|sterol-desaturase-family-protein	gnl\|CDD\|225546	COG3000, ERG3, Sterol desaturase [Lipid metabolism].	6.94805e-38
NZ_CP050994.1\|WP_168235384.1\|2077819_2079220_-\|amino-acid-permease	gnl\|CDD\|129983	TIGR00905, Arginine/ornithine_antiporter, transporter, basic amino acid/polyamine antiporter (APA) family. This family includes several families of antiporters that, rather commonly, are encoded next to decarboxylases that convert one of the antiporter substrates into the other. This arrangement allows a cycle that can remove proteins from the cytoplasm and thereby protect against acidic conditions. [Transport and binding proteins, Amino acids, peptides and amines].	1.3754e-159
NZ_CP050994.1\|WP_168235389.1\|2090564_2092172_+\|malate-synthase-A	gnl\|CDD\|236432	PRK09255, PRK09255, malate synthase; Validated.	0
NZ_CP050994.1\|WP_168235386.1\|2088432_2088972_-\|tRNA-adenosine(34)-deaminase-TadA	gnl\|CDD\|182786	PRK10860, PRK10860, tRNA-specific adenosine deaminase; Provisional.	1.31627e-89
NZ_CP050994.1\|WP_168235383.1\|2073503_2074292_+\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270347	cd13629, PBP2_Dsm1740, Amino acid-binding domain of the type 2 periplasmic binding fold superfamily. This subfamily includes the periplasmic binding protein type II (BPBII). This domain is found in solute binding proteins that serve as initial receptors in the ABC transport, signal transduction and channel gating. The PBPII proteins share the same architecture as periplasmic binding proteins type I (PBPI), but have a different topology. They are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBPII proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the family includes ionotropic glutamate receptors and unorthodox sensor proteins involved in signal transduction.	7.33164e-132

>NZ_CP050994.1|WP_025327511.1|2082481_2083192_-|phosphate-signaling-complex-protein-PhoU
MDNMNLNKHISGQFNAELENVRNQVLVMGGLVEQQLTDAISAIHIQDLDAARKIVANDHKVNAMEVAIDEECTRIIAKRQPTASDLRLVMAIIKTITDLERIGDVADKIARMLTDNANKPQPPLVSLENMGRRTIKMLHDVLDAFARMDLEAAIAVYKEDDKVDREYESIIRELMTYMMEDPRTIPQVLNVLWAARAIERVGDRCQHICEYIVYYVKGKDVRHTKADELSDLLGKH
>NZ_CP050994.1|WP_106886381.1|2080969_2082289_-|HlyC/CorC-family-transporter
MSFADSLFFLMLLVAGSVFFSLSEISLAASRKIKLQVMADEGNRHAEKVLALQAQPGNFFTVVQIGLNTVAILGGILGESALNPAIKSLISGFYQGPWLSQISSIASFVFVTGMFILIADLMPKRLAMTMPERVAVVVVRPMLLCVTLLMPLVWFFNGLANALFRLLRVSMVRNDEITSDDIYAVMDAGAEAGVIQREEHQLIENVFELQSLGVTSAMTARESLIYFTLQEGEESIKAKIAEHPHNKFLVCDHNLDSIKGFVDAKELLIRVISGQSIDLNSGSLVQNVIIIPDTLNLYEAMEYFKNHRGDFAVVMNEYALVVGIVTMNDLMSTVMGEWATHAMEEQIVQRDENSWLVDGVTPISDVMRAFDIEEFPGNQNYETIAGFIMFMLRKIPKRTDSVKYAGYKFEVVDIDSYKIDQLLVTRVEPVLAEKPALES
>NZ_CP050994.1|WP_168235385.1|2080407_2080950_-|hypothetical-protein
MKMPSYSRALSCVALALALGACSQSAPRKPAAVPKPVAPKAAVVAPQPDPDAVVQSAVAEPSPVFDEEYHGPDQGSLESVTALFARGYIESAMRETMLAAVHSDYPLLGMRDVRLTDPVAKFLTSAQARTTAHDYLYAGVQRRLGRPLSPAQWEQIWQGFPQQGRVSDWVKQTKRVLAGR
>NZ_CP050994.1|WP_163135114.1|2079229_2080132_-|homocysteine-S-methyltransferase-family-protein
MDTKDLWVLDGGMGRELARRGAPFRQPEWSALALMEAPETVREVHQAYVASGARVITTNSYALVPFHIGDERFAADGERLAALAGQLARDVADGQAGAVQVAGSLPPLFGSYRADLFEADRVSELATPLIRGLSPHVDIWLAETMSLIAEPLALKALLPGDGKPFWVSFTLEDEAPGSEPRLRSGERVADAVTALASAGVSAILFNCCQPEVIEGALKVASARLQALGRTDIRLGAYANAFPPQPKEATANDGLDEIRADLGPQDYLGWAERWRGAGASLIGGCCGIGPEHIQALSSQLR
>NZ_CP050994.1|WP_168235384.1|2077819_2079220_-|amino-acid-permease
MKESKIGLWSLTALVFSSMVGAGIFSLPQNMAEVAGARAVLIGWGVTGVGILALAASFLYLSRLRPDLDGGIYSYARAGFGDLVGFFSAWGYWLCATIGVVGYLVIAFAALGSFVDTPEQIWFGDGNTLAAFIGESCILWAVHLLVARGVQQAALFNLVATLAKSLPLLLFILFACCWFDPVTFAADQQGSTLAVPVSEQVRNTMLITLWVFTGIEGAAVLSARARNKRDVGTATVLGVVLALLLYVLISVLALGILSRPELAALPNPSMAGLMTQMTGSWGKVLISVGLIVSVLASYVSWTLFSAEVPFSAARHGAFPAIFRRQNRNGTPIASLWLTSLTVQGCLLLVWLLGKGYTNLLLISTSMILVPYLLIGLFLLKLSLSGQGNGLVRAVALVSSGYGFWLLYAAGVEYLLLSLLLYGPGLLLFLYSRRQLGADQRLSLRERLLAGITLVSLVPAIWSFAHV
>NZ_CP050994.1|WP_163135112.1|2076908_2077748_+|sterol-desaturase-family-protein
MDVQLLLLYLSPLFLAFVGWEMLYLRKHGAAFPTASYQWRDLFANAALALMHQGGDALAAIAIAYLYEGLWGWRLFDIELNLWSLLLLFLLQDLCYWLFHFASHHVRWLWASHVVHHSSERLNLSTAFRQSLMYPVSGMWLFWIPMILIGFPPEAVVATVLLSLGFQFFVHTQVVGKLGWLERVFNTPSHHRVHHASNPKYIDRNFAGVLIIWDRLFGTFVEEDLGEPCRFGITKPVHSFNPLTLTFHEWRDMLHDARGLPWSEKLKVLFGKPAGPGGA
>NZ_CP050994.1|WP_163135110.1|2075437_2076181_+|ATP-binding-cassette-domain-containing-protein
MRTATDPIIKASGVEKFYGTEVHALKNVSTQVAEGEVVVIVGPSGSGKSTFLRTLNQLETINDGHIEVDGISLTEPGDVNKLREEVGMVFQSFNLFPHLNVLDNISLAPQKVRGLSRKDAEERAKALLLKVGLSNKAQSYPSQLSGGQQQRVAIARALAMQPRIMLFDEPTSALDPEMVGEVLDVMKGLAREGMTMVVVTHEMGFAREVADRVLFMESGELLVDEKPTDFFDNPPSPRLRQFLSQVL
>NZ_CP050994.1|WP_163135409.1|2074388_2075348_+|ABC-transporter-permease-subunit
MEKQPNLLLWHGVFLLMLLAAIFGIYKAVQAVDYTWRWERIPQYIAYQAEQKQYAEFDGTVVAGTTAAEKGQLFLQDDLDPNRRQAIASTGAQVAEGDTVFQGDTLDTQLSWTAGPIAWGVWVTVKLSLVAGVFAILLGTLAGLARLSPNPALRNLAVTYVELIRGTPLLVQIFIVYFFIGTVLNLDRFTAGVAALAVFTGAYVAEIVRAGISSIHKGQMEAGRSLGLTSAQTMRYVILPQAFKRVLPPLAGQFINLIKDSSLVSVISITDLTKAGREVVSSTFSPFEVWFTVALLYLVLTGTLSFLVRRLEVKYARSN
>NZ_CP050994.1|WP_168235383.1|2073503_2074292_+|transporter-substrate-binding-domain-containing-protein
MIKKLILSTLLLCGLANAAPSSTLDAVLERGVLRVGFDAGYQPFEMTNKQGQYIGFDVDLAKMVAKEMGVKVEFVNTAWDGIIPALLTDKFDVIMGGMTVTPQRNLRVNFADPYIVVGQTIVLRKDKAGEIKSFSDLNDPKYKIAVKLGTTGEQAVKRLIPKATLLQFETQGDAKLEVINGKVDAFVYDLPYNAIFASQNTGAVVHLDKPFTFEPLAWAIRKGDQDTLNWFNNYLRQIKGDGSYDRLYKKWFESNAWLNQLK
>NZ_CP050994.1|WP_163135108.1|2071912_2073040_-|diguanylate-cyclase
MDTSILLNLDVFTLMLMALGGYSLGFITLSIIWSTHREIPGLGLWWWSSLCALAAQSLFFMQAFAPHIAGIWLANLLITLCIALMPLALQRFFGEPPNWRAFALFMLVYLLILCWSVLFNDEMAPRVLLACLSYMVLGAVVVLLIWRHGYPAYLPAVLVFTVVNILLYGFNLVRMGALLSGEVRVLMDPHVVNVLPFLSMLMGNYLSTFGVLLLCTQYRALALRRQASQDPLTGLLNRRGFMERCVTAPKQGALVVLDLDDFKQINDRHGHEAGDRVLAAVGAYLAGQGDLVASRFGGEEFVLLLPEGDALAQQARCEQIRQGIATLPLDGIQVTASLGLVPYARGWHLDTLFGQADRALYQAKRSGKNRVCLPA
>NZ_CP050994.1|WP_005328825.1|2083363_2084182_-|phosphate-ABC-transporter-ATP-binding-protein
MINVTPTSTQHTALDLLNLSPEQTALEVKDLNLYYGNKQALFNVNMKIPKGQVTAFIGPSGCGKSTLLRCINRMNDLVEICRIEGEIQLHGHNIYDKSVDVSALRRQVGMVFQRPNPFPKSIYENVVYGLRLQGINDRRTLDEAAERSLRGAALWEEVKDRLHDNAFGLSGGQQQRLVIARAIAIEPEVLLLDEPTSALDPISTLTIEELINELKSQFTVVIVTHNMQQAARVSDQTAFMYMGELIEYSNTNTIFTTPAKKKTEDYITGRYG
>NZ_CP050994.1|WP_106886380.1|2084289_2085939_-|phosphate-ABC-transporter-permease-PstA
MGKWFKSGAPWIWMTGGAVSLSLVAVLGLLLLIGWRGLVYFWPHPIYEWQLEDASGNKSVLIGEINDREMVPVERLRAAGQALEGEERELLTRYLVKTGNREFVDLDFRWVLETDIKSQSQPAELAMVERATNGNFYGYITSVKEDGKELTADLHPALQRVLARANALSEQANDLQKGDIGGINYQLERLRLKERKAELEGELTDALKADLAAQRQALNDRYLVLEKELFSLRAQADRDAITVKDMRGELVTMPMSKVLDVVWPNDMSLPAKVGHWFHQIGKFVSDDPREANTEGGVFPAIFGTVFMVLLMAIIVTPLGVVAAVYLHEYAGKNSLTKIIRIAVINLAGVPSIVYGVFGLGFFVYTLGGSLDQLFYPEALPSPTFGSPGVIWSALTLAILTLPVVIVSTEEGLARIPSTIRQGSLALGATQAETLWRIVLPMASPAIMTGLILAIARAAGEVAPLMLVGVVKLAPTLPMDGNFPYLHVERKFMHLGFHIYDVGFQSPNVEAARPLVYATSFLLVTVIVGLNLTAIGIRNHLREKFRSLEH
>NZ_CP050994.1|WP_111910105.1|2085990_2088228_-|ABC-transporter-permease-subunit
MSSESLNLVMAGSRKRRIKDKLAKYGVTTGGALVLVALLLIFFYLLYVVKPIFNGASVEATSSFTLPTQGKTAWLGVEEQNEIGYRFNDQGQVSFFAVKADGGVKVGQVLGQASVAGDVTAVAVPAPGQKLIAYGFADGKATVVQPSFKVSYPNDVRVIEPSLQYPFGEEPVVIDPQGKALTRMVFEATKDKMATAAVTEDGRGVMTVMSGEENFLSGEVEWSSQNYAIPSLPRHVDQMLLTPNLRILFVREGNRLSVYDIHNLSDISLRDVMEINAPNADVTQVALLSGASSLLVGNDNGVISQWFEVAKDGKRQFTQIRDFKGDGPVALLTPEHFRKGFISAAKDGTINFFHATGEAKLLGETIEGGALAALAISPRHNLLLTQQGNDFKVFEVENDHPEVTWSALWQEVWYEGYPEPMYVWQSTSASNDFEAKLSLVPLVFGTLKASFYAMLFAVPLGVAGAIYTAYFMSAGLRKYVKPTVEIMAALPTVILGFLAGLWLAPIIEGALPGVILLLLLLPMGMLLTALVWNYLPERGKSWLPEGWHAILLIPVLLLIGWGAFALSPLIENAFMHGDSRIWLTHEMGIKFDQRNSLVVGIAMGFAVIPTIFSIAEDAVFSVPKHLTQGSLALGATPWQTLSRVVILTASPGIFSAVMMGLGRAVGETMIVLMATGNTPIMDFSMFQGLRTLAANIAVEMPESEVGSSHYRVLFLAAFVLFVFTFMFNTLAEFIRQRLREKYSSL
>NZ_CP050994.1|WP_168235386.1|2088432_2088972_-|tRNA-adenosine(34)-deaminase-TadA
MTPSENNDVFDQARQDEHWMRHAMALAARAEGIGEIPVGAVLVLGDEVVGEGWNRSISAHDACAHAEIMAIRAAGITQQNYRLLDTTLYVTLEPCCMCAGALIHSRVKRVVYGARDLKTGAAGSVFDILQDPRHNHRVALTGGVLAEACSAQLSDFFKRRRAEKKAAREALKQSGGPTL
>NZ_CP050994.1|WP_168235387.1|2088968_2089130_-|hypothetical-protein
MNAAEMQITQDERWMRHAMALAAKAEGETSEILVGTVLLSEVRRLHSDREVRA
>NZ_CP050994.1|WP_163135121.1|2089720_2089861_+|hypothetical-protein
MNQAVDTQPDQPLLSSPHSDPESTDTGLGGTVHLDVIDLAAPDDDY
>NZ_CP050994.1|WP_168235388.1|2090063_2090249_-|hypothetical-protein
MQKQIPTLLQALRKQLYEMPAANTVGIWHVKSLTGELLFKTKWSNLAKRGQRRACGGNDEQ
>NZ_CP050994.1|WP_168235389.1|2090564_2092172_+|malate-synthase-A
MSAPAQTISSTRLRIQGEMLPDYAQILTPDAVALVSELVERFAPQRNELLKQRVARQARIDGGELPDFLPETAHIREGSWTVRGIPADLQDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPAWNKVIEGQINLRDAVNGTVSYTSPEGKAYTLNPDPAVLICRVRGLHLPEKHVTFDGDAIPGGLFDFALYFLHNHKALLAKGSGPYFYLPKLQSHLEGRWWSEVFAWTEDKFGLPRGTIKATVLIETLPAVFEMDELLYQMKDHIVALNCGRWDYIFSYIKTLKNHPDRVLPDRQVVTMDKPFLSAYSRLLIKTCHKRGALAMGGMAAFIPAKDPAVNAEVFAKVKADKEREANNGHDGTWVAHPGLADTAMAVFNAAIPAGTKNQIGVLREQDAPITAAELLTPCEGERTEAGMRTNIRVALQYLEAWINGNGCVPIYGLMEDAATAEISRTSIWQWIRHGKSLSNGQVVTKALFRQMLAEEQQVVKAELGDARWQAGRFAEASELMEQITCADTLIDFLTLPGYERL
>NZ_CP050994.1|WP_111910109.1|2092244_2093558_+|isocitrate-lyase
MALTREQQIQAIEKDWAENPRWKGIKRGYSAEDVVNLRGSLQPAHTLAQRGADKLWELIHGGAKKGYVNCLGALTGGQAVQQAKAGIEAIYLSGWQVAADNNLSSTMYPDQSLYPANSVPSVVERINNSFARADQIQWANKVGPQDAGFIDYFLPIVADAEAGFGGVLNAFELMKGMIEAGAAGVHFEDQLASVKKCGHMGGKVLVPSQEAVQKLIAARLAADVCGTTTLVIARTDANAADLLTTDADPYDAGFLTGERTAEGFYKVQAGIEQAISRGLAYAPYADMVWCETAKPDLDEARQFAEAIKAQYPDKILAYNCSPSFNWKKNLDDATIARFQQELSDMGYKYQFITLAGIHNMWFHMYELAYQYARGEGMKHYVEMVQQPEFAAAERGYTFVAHQQEVGTGYFDKVTTVIQGGQSSVTALTGSTEEDQFH
>NZ_CP050994.1|WP_162520047.1|2093668_2094370_-|DnaA-inactivator-Hda
MKQPAQLSLAVQLPDDETFVSFYPGNNAHLITALKNAAIGQGAPFLYFWGAKGSGRSHLLHATCAEVNARDAAAAYLSLDQFEQLDPSMLDALESLPLVCLDSLEAIAGNGLWERALFDFYNRWREKGEGTLVVTGCSAPRKLGLQLPDLASRLDWGVSFHLDELDDEGKLSALQLRAELRGFKLPIDVGRFLLNRLSRDMRTLLTTLNQLDNASFRAKRKLTIPFVKEILEL

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Crispr_ID: NZ_CP050994_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_11

2535289-2535378

Orphan

Consensus_repeat	Method
GTAACTCGCTCATCACGCCTCCTGTTCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_11

>merge|NZ_CP050994|11|2535289-2535378|CRISPRCasFinder
GTAACTCGCTCATCACGCCTCCTGTTCATACAGAACATGAATAGGGCCGGGGCTGGATTGGGGTAACTCGCTCATCACGCCTCCTGTTCA

>NZ_CP050994|11|11|2535289-2535378|CRISPRCasFinder
GTAACTCGCTCATCACGCCTCCTGTTCA	TACAGAACATGAATAGGGCCGGGGCTGGATTGGG
GTAACTCGCTCATCACGCCTCCTGTTCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_042648621.1\|2526677_2527184_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP050994.1\|WP_106886121.1\|2529410_2530706_-\|phosphate-regulon-sensor-histidine-kinase-PhoR	unknown	unknown	gnl\|CDD\|182895
NZ_CP050994.1\|WP_025327848.1\|2528146_2529121_-\|phosphate-ABC-transporter-substrate-binding-protein-PstS-family-protein	unknown	unknown	gnl\|CDD\|270284
NZ_CP050994.1\|WP_025327844.1\|2524896_2525622_-\|copper-homeostasis-protein-CutC	unknown	unknown	gnl\|CDD\|225684
NZ_CP050994.1\|WP_042649487.1\|2537169_2537964_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP050994.1\|WP_168235593.1\|2542878_2544189_-\|2-hydroxycarboxylate-transporter-family-protein	unknown	unknown	gnl\|CDD\|377030
NZ_CP050994.1\|WP_106886112.1\|2544881_2545937_+\|HlyD-family-secretion-protein	unknown	unknown	gnl\|CDD\|224482
NZ_CP050994.1\|WP_139744978.1\|2524105_2524717_-\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|183207
NZ_CP050994.1\|WP_168235589.1\|2532046_2533327_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_CP050994.1\|WP_168235591.1\|2538060_2538948_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|273359
NZ_CP050994.1\|WP_168235595.1\|2547461_2548334_+\|beta-1,6-N-acetylglucosaminyltransferase	unknown	unknown	gnl\|CDD\|367100
NZ_CP050994.1\|WP_163153480.1\|2523078_2523960_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP050994.1\|WP_042648620.1\|2527171_2527981_-\|M48-family-metallopeptidase	unknown	unknown	gnl\|CDD\|320690
NZ_CP050994.1\|WP_042040713.1\|2544406_2544880_+\|transcriptional-regulator-SlyA	unknown	unknown	gnl\|CDD\|179596
NZ_CP050994.1\|WP_168235588.1\|2530714_2531404_-\|phosphate-regulon-transcriptional-regulatory-protein-PhoB	unknown	unknown	gnl\|CDD\|131209
NZ_CP050994.1\|WP_168235590.1\|2535591_2537109_+\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143434
NZ_CP050994.1\|WP_168235592.1\|2541305_2542856_-\|NAD-dependent-malic-enzyme	unknown	unknown	gnl\|CDD\|237414
NZ_CP050994.1\|WP_163147730.1\|2531506_2531917_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319924
NZ_CP050994.1\|WP_168235594.1\|2545947_2546976_+\|DUF2955-domain-containing-protein	unknown	unknown	gnl\|CDD\|371403
NZ_CP050994.1\|WP_042649489.1\|2539025_2539718_-\|response-regulator	unknown	unknown	gnl\|CDD\|226931

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_042648621.1\|2526677_2527184_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.19453e-12
NZ_CP050994.1\|WP_106886121.1\|2529410_2530706_-\|phosphate-regulon-sensor-histidine-kinase-PhoR	gnl\|CDD\|182895	PRK11006, phoR, phosphate regulon sensor histidine kinase PhoR.	0
NZ_CP050994.1\|WP_025327848.1\|2528146_2529121_-\|phosphate-ABC-transporter-substrate-binding-protein-PstS-family-protein	gnl\|CDD\|270284	cd13566, PBP2_phosphate, Substrate binding domain of putative ABC-type phosphate transporter, a member of the type 2 periplasmic binding fold superfamily. This subfamily contains uncharacterized phosphate binding domains found in PstS proteins that serve as initial receptors in the ABC transport of phosphate in eubacteria and archaea. After binding the ligand, PstS interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The PstS proteins belong to the PBPII superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.02933e-86
NZ_CP050994.1\|WP_025327844.1\|2524896_2525622_-\|copper-homeostasis-protein-CutC	gnl\|CDD\|225684	COG3142, CutC, Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism].	3.60288e-85
NZ_CP050994.1\|WP_042649487.1\|2537169_2537964_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	4.59185e-26
NZ_CP050994.1\|WP_168235593.1\|2542878_2544189_-\|2-hydroxycarboxylate-transporter-family-protein	gnl\|CDD\|377030	pfam03390, 2HCT, 2-hydroxycarboxylate transporter family. The 2-hydroxycarboxylate transporter family is a family of secondary transporters found exclusively in the bacterial kingdom. They function in the metabolism of the di- and tricarboxylates malate and citrate, mostly in fermentative pathways involving decarboxylation of malate or oxaloacetate.	1.57329e-162
NZ_CP050994.1\|WP_106886112.1\|2544881_2545937_+\|HlyD-family-secretion-protein	gnl\|CDD\|224482	COG1566, EmrA, Multidrug resistance efflux pump [Defense mechanisms].	1.36431e-66
NZ_CP050994.1\|WP_139744978.1\|2524105_2524717_-\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|183207	PRK11570, PRK11570, peptidyl-prolyl cis-trans isomerase; Provisional.	5.55844e-81
NZ_CP050994.1\|WP_168235589.1\|2532046_2533327_-\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.9771e-49
NZ_CP050994.1\|WP_168235591.1\|2538060_2538948_+\|DMT-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.08823e-18
NZ_CP050994.1\|WP_168235595.1\|2547461_2548334_+\|beta-1,6-N-acetylglucosaminyltransferase	gnl\|CDD\|367100	pfam02485, Branch, Core-2/I-Branching enzyme. This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme and core-2 branching enzyme. I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development. Core-2 branching enzyme forms crucial side-chain branches in O-glycans. This is a fmmily of glycosyl-transferases that are Type II membrane proteins that are found in the endoplasmic reticulum (ER) and Golgi apparatus.	1.17078e-39
NZ_CP050994.1\|WP_163153480.1\|2523078_2523960_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.76165e-90
NZ_CP050994.1\|WP_042648620.1\|2527171_2527981_-\|M48-family-metallopeptidase	gnl\|CDD\|320690	cd07331, M48C_Oma1_like, Peptidase M48C, integral membrane endopeptidase. This subfamily contains peptidase M48C Oma1 (also called mitochondrial metalloendopeptidase OMA1) protease homologs that are mostly uncharacterized. Oma1 is part of the quality control system in the inner membrane of mitochondria, with its catalytic site facing the matrix space. It cleaves and thereby promotes the turnover of mistranslated or misfolded membrane proteins. Oma1 can cleave the misfolded multi-pass membrane protein Oxa1, thus exerting a function similar to the ATP-dependent m-AAA protease for quality control of inner membrane proteins; it cleaves a misfolded polytopic membrane protein at multiple sites. It has been proposed that in the absence of m-AAA protease, proteolysis of Oxa1 is mediated by Oma1 in an ATP-independent manner. Oma1 is part of highly conserved mitochondrial metallopeptidases, with homologs present in higher eukaryotes, eubacteria and archaebacteria, all containing the zinc binding motif (HEXXH). It forms a high molecular mass complex in the inner membrane, possibly a homo-hexamer.	1.83072e-85
NZ_CP050994.1\|WP_042040713.1\|2544406_2544880_+\|transcriptional-regulator-SlyA	gnl\|CDD\|179596	PRK03573, PRK03573, transcriptional regulator SlyA; Provisional.	3.8264e-33
NZ_CP050994.1\|WP_168235588.1\|2530714_2531404_-\|phosphate-regulon-transcriptional-regulatory-protein-PhoB	gnl\|CDD\|131209	TIGR02154, PhoB, phosphate regulon transcriptional regulatory protein PhoB. PhoB is a DNA-binding response regulator protein acting with PhoR in a 2-component system responding to phosphate ion. PhoB acts as a positive regulator of gene expression for phosphate-related genes such as phoA, phoS, phoE and ugpAB as well as itself. It is often found proximal to genes for the high-affinity phosphate ABC transporter (pstSCAB; GenProp0190) and presumably regulates these as well. [Regulatory functions, DNA interactions, Signal transduction, Two-component systems].	2.62733e-134
NZ_CP050994.1\|WP_168235590.1\|2535591_2537109_+\|aldehyde-dehydrogenase	gnl\|CDD\|143434	cd07116, ALDH_ACDHII-AcoD, Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like. Included in this CD is the NAD+-dependent, acetaldehyde dehydrogenase II (AcDHII, AcoD, EC=1.2.1.3) from Ralstonia (Alcaligenes) eutrophus H16 involved in the catabolism of acetoin and ethanol, and similar proteins, such as, the dimeric dihydrolipoamide dehydrogenase of the acetoin dehydrogenase enzyme system of Klebsiella pneumonia. Also included are sequences similar to the NAD+-dependent chloroacetaldehyde dehydrogenases (AldA and AldB) of Xanthobacter autotrophicus GJ10 which are involved in the degradation of 1,2-dichloroethane. These proteins apparently require RpoN factors for expression.	0
NZ_CP050994.1\|WP_168235592.1\|2541305_2542856_-\|NAD-dependent-malic-enzyme	gnl\|CDD\|237414	PRK13529, PRK13529, oxaloacetate-decarboxylating malate dehydrogenase.	0
NZ_CP050994.1\|WP_163147730.1\|2531506_2531917_-\|VOC-family-protein	gnl\|CDD\|319924	cd07263, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	4.03464e-37
NZ_CP050994.1\|WP_168235594.1\|2545947_2546976_+\|DUF2955-domain-containing-protein	gnl\|CDD\|371403	pfam11168, DUF2955, Protein of unknown function (DUF2955). Some members in this family of proteins with unknown function annotate the proteins as membrane protein. However, this cannot be confirmed.	4.19093e-45
NZ_CP050994.1\|WP_042649489.1\|2539025_2539718_-\|response-regulator	gnl\|CDD\|226931	COG4565, CitB, Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms].	1.25452e-62

>NZ_CP050994.1|WP_168235589.1|2532046_2533327_-|diguanylate-cyclase
MTPSYSRVTNMLFWSLLLGSLLAILVFEFGPERRLDILSQASLVARAQDDRAHGGQSVTTLIPGGDKPAIDCKLRAGHSSPFCELILTLSAPEWGLDLSHFNGVRVKLRAEGSEPQSWRLYLRNYDPAYSIAGDEISHKFNEVLFRPDDYGRIQDVPLKVFAPSSWWVQQYRIPLAQQGADLHHVYAIELATDDRMQPGDYRLILEKLEFYGRWGKPGDFYRQLLLGWLIYGILLFLTQYLLMGDKLRKAREARLAAEALSQSLSEQYRRTEEEARYDPLTGALNRLGGEKLLSELGEMPLSFIYIDIDHFKGVNDTHGHPMGDEVLKHMVSELLRHCDSLCRLVRWGGEEFVLVCLHHEQARAERLAERLRGALEAYRDWPLGLRITASFGVAERRGDPLELTLKRADEALYQAKERGRNRVEVG
>NZ_CP050994.1|WP_163147730.1|2531506_2531917_-|VOC-family-protein
MSQHLGALTLLVADYDQAIRFFTEGLGFELLEDTPLDEPGKPGKRWVRVAPKGAPGSALLLAQAANAQQQAAIGQQGGGRVFLFLETDDFWGDYQRMQQYGVHFCEQPRHEPYGTVVVFEDISGNRWDLLQRIAAN
>NZ_CP050994.1|WP_168235588.1|2530714_2531404_-|phosphate-regulon-transcriptional-regulatory-protein-PhoB
MAKRILVVEDEAPIREMLCFVLEQKGYETVEAEDYADGLAKVREPYPELIVLDWMMPGGSGIQFIKQLKQDEVTRQIPVVMLTARGEEEDKVRGLEAGADDYITKPFSPKELTARLHAVMRRVSPTSVDEVIEVQGLKLDPVSHRVSAEEKALDMGPTEFKLLHFFMTHPERVYSREQLLNNVWGTNVYVEDRAVDVHIRRLRKAIEETGHDRLIQTVRGAGYRFSTRL
>NZ_CP050994.1|WP_106886121.1|2529410_2530706_-|phosphate-regulon-sensor-histidine-kinase-PhoR
MLQPYAWRRQLWRMAFFYAPFVLVGWLIEHLSLCLLVATVLHLGWHYRFQKRLSDWLWHDRSLVPPHGSGSWEYIFNGIYKLQQRHRARRRELAGLIRRFREGAEALPDAAVVFRTDGSILWCNRLAEQLLGFRWPEDAGQHIGNLIRHPGFVAYLGKGQYDEPFEMSSPINEEKFLEFRIMPYAEDQAMLVVRDVTRLRSLEKTRKHFVSNVSHELRTPLTVLKGYLEMTEEPPPPAMWAKAHRVMMEQTIRMDNLVNQLLTLSRIEAAPTVDLSHLVDMPAMLGLLEQEARALSGESAHQIEFQVQSNLFVKGDRDQLRSAVSNLVYNAIHYTPAGRKITVEWRKQGAMALFVVQDQGEGIAPEHLARLTERFYRVDKARSRHTGGSGLGLAIVKHALSHHDAQLEIESRVGQGSRFSFLIPARMVVVK
>NZ_CP050994.1|WP_025327848.1|2528146_2529121_-|phosphate-ABC-transporter-substrate-binding-protein-PstS-family-protein
MKLNKLAGVIGFTAATLFSVSALAAGVDKDLPDYTPTSGISGNLSSVGSDTLANMMTLWAEEFKRVYPNVNVQIQAAGSSTAPTALTEGVAQFGPMSRAMKAGEEEAFEKRYGYKPTAIRVAVDALAVFVNKDNPIKGLTMEQVDSVFSSTLKCGEAKAATKWSDLGLDGNWSSKDLQLFGRNSVSGTYGYFKEHALCNGDFKSGVNEQPGSASVVQSVSASLNGIGYSGIGYVTSGVRAVPLSKDGKTFVEATAENALTGKYPLSRFLYVYVNKAPNKPLSPMEQEFVKMMLSKAGQTIVAKDGYVPVPAKIVQADLKKLGIM
>NZ_CP050994.1|WP_042648620.1|2527171_2527981_-|M48-family-metallopeptidase
MRASSLSKFGLAALCSALLASCAQSPTGRSQMLLFSPQQMNQLGADSFEQMKKQEKVSKDAKVNAYVSCVAKAVTAQVPASYGITSWEVVVFDSKEVNAFALPGGKIGVYSGLLKVAKNQDQLATVIGHELTHVLAQHSNERLSRDQLTGIGLAVADAAIGSSQGGGATMAALGLGVQVGIALPYGRAQESEADRLGLDLMARAGFNPAEAIPLWQNMSAAAGGKAPPQLLSTHPSDENRITELQAQQAQAEPLYRQARAAGLTPQCKA
>NZ_CP050994.1|WP_042648621.1|2526677_2527184_-|GNAT-family-N-acetyltransferase
MQGITLRLARPADAAAMTVMQRASWLAAYGGVLGEDLLAQLAVTEHLQIWRRRLAEPAPIPMLLCQDEVVIGLLYWHPAHEEGLMTARIRALYLHPDHWRRGHGKRLWQAVAVQMRRAGCECVRLWLLDGNHIGEGFYLRRGFVFDGQERTLTSLGQPCLQRQMFRLL
>NZ_CP050994.1|WP_025327844.1|2524896_2525622_-|copper-homeostasis-protein-CutC
MTRLEICIDNLESLFTAQQAGADRIELCSALGLGGLTPSYGFMQQVARHATIPVYAMIRPRAGDFCFSAAEFELMLLDIAAARAAGLQGVVVGLLDEGGRVPAAQLQQLVEAAGPLGVTFHRAIDLSSNWRADLETIVAAGCERILSSGHAPTALAGLETLQAMQQTLAGRASLMPGAGVNADNVRTILEFTGVSEVHMSGMGWRGGMVPHGVNMGTSDDGRVNITDGAKVAAVRALLDRA
>NZ_CP050994.1|WP_139744978.1|2524105_2524717_-|FKBP-type-peptidyl-prolyl-cis-trans-isomerase
MSQYDSIEQKASYGIGRNMGDQLAQQAFAGLDIPALQQGLADALNGLEFAVSRDDINDAFQVITARMQEEQEAVAKAAAADGEAFLADNAKRADVKVTDSGLQYEVMVEGKGAVPVAGQSVRVHYHGTFTHGGVFDSSVARGQPAEFPVTGVIAGWVEALQMMPVGSKWKLYIPQDLAYGARGAGSIPPYSALVFEVELLDIL
>NZ_CP050994.1|WP_163153480.1|2523078_2523960_-|ATP-binding-cassette-domain-containing-protein
MAAIIEVVDLIKHFPGVRAVDGLSFAIPAGSCFGLLGPNGAGKTTTIELLEGILTPDSGQILFHGAPRGPDYRSRIGIQFQHTALQDFLTVRDTLRLFASLYPNPLPRELLIELCALGEFIDRDSRKLSGGQRQRLLLALALLGDPELLFLDEPTTGLDPQARHHFWQRIEAIKAQGKTVVLTTHYMDEAQQLCDRIAIVDHGHLLSLDTPAALLARHFDGVLVRLADHPALASLGYPLLPHGDQVELSCPDVAALLPRLLSLGVPLTGMQVRSPNLEDLFLHLTGHSLRSGA
>NZ_CP050994.1|WP_168235590.1|2535591_2537109_+|aldehyde-dehydrogenase
MIYTAPGQAGALVSFKSRYDNFIGGDWVAPRAGRYFENVSPVDGKVFCEVARSDAADIELALDAAHKAFASWSKTSVTERSNLLLRIADRIEQNIEVLAVAETWENGKAVRETLAADLPLVVDHFRYFAGCIRAQEGSAAELDQHTVSYHFKEPIGVVGQIIPWNFPLLMAAWKLAPVLAAGCCSVLKPAEQTPVTIMLMMDLIKDILPPGVVNVVNGFGAEAGQALATSDRIQKLAFTGSTEVGAHILRCAADKLIPSTVELGGKSPNIYFADVMQHESSYIDKAVEGMLMTFFNQGEVCTCPSRALVQASIYDDFMDRVLARARTIVQGNPLDTATQVGAQASREQFDKILSYMEIGRGEGAKMLIGGGPAKVNGLEGGFYIQPTIFSGQNKMRVFQEEIFGPALGVTTFKDEADALAIANDTQYGLGAGLWTRDSNLAWRMGRGIQAGRVWVNCYHAYPAHAAFGGYKKSGIGRETHKMMLDHYQNTKNLLVSHDINPPGFF
>NZ_CP050994.1|WP_042649487.1|2537169_2537964_-|AraC-family-transcriptional-regulator
MGSLTLAEQDRLLADPNPLYFRYRQIQGGNACAEHTHPWGQLSLISLGVMVVEVGGERLVAPADYLIWVPANLPHSAFNEQTLDYTSIYVSHALAPRLPREPQLLELTPLLRALLEDFTQRRVGHLEDEWDARQGELFIEKLARTRCQPSYLPQSRDRLLAPLLAALHAAPEDNRTLAEWAKVLHTTERTLARRCQKELGMSLGQWRTRLRMVKALDWLRGEMPVQEIAWRLGYTSTSAFIAMFQREQGCAPQRYRQQLGQPGG
>NZ_CP050994.1|WP_168235591.1|2538060_2538948_+|DMT-family-transporter
MPFLFPLLAILIWAANTVVSKAAAGVLDPAAISFYRWVIAALALSPFCLPQLWRRRAEIRPWLGKLLVLAALGMVLYQCLAYYAAHSTSATNMGVIGSLIPLLTLLQSALFFGQRPGKQALLGMSLSLFGVLWLLGQGNPLALLHDGINPGDGLMLLGSASYALYGLLIRRWQLPFGPWLNLYLQILLAVLLLIPVALSADSLAVPAEGWGLVLFAGLASSLLAAYCWMRGLAAMGAERTSVFMNLMPLCTALIAVITLGEPIHGHHLLGGGLILTGVMISQFKPRARPALVEGA
>NZ_CP050994.1|WP_042649489.1|2539025_2539718_-|response-regulator
MKPIFTLVIEDDERIGAILAELISSTPGYSLLGRAESLAQADLMMRATEPQLLVVDISLPDGSGLEWVNRLRSHNREVFVVMVTASCDVETIQQALNLGVQDYIIKPLRLFRIQQSLDEILTLHRRLCERGLLEQSDLDRLMGKGRIQPREVRDTPKGIDAITLRQVLELLAGEPDTAFSTDTVALRLSLSRTTARRYLEFLESEDKLDVDLNYGQRGRPERRYHWRRSS
>NZ_CP050994.1|WP_168235592.1|2541305_2542856_-|NAD-dependent-malic-enzyme
MNDIMMGTSLPYAERKRQGLMGRMPHKEESLSQQRRRIYRLVSAMQSPFDQHLLLRQLQEDNPVLFYDLVRHHLPELLPIIYTPVVGEACQRHSDLYLRSHGLYLSWHDRDELDAIFAAVEQEVDVIVISDGERVLGLGDLGIGGMGICIGKLALYSAAGGINPARTLPLCVDVGTNNPALLEDDSYLGWQAPRIDGETYYHFMDKVVAAIHKRWPQVVLQFEDFAGKHAANLLARYRDELCMFNDDIQGTAAVASACVLAGLQQAGSTLADTPVLIVGAGSAGCGIAAMLARLAGSPERVQLFDQDGLVCLDRANLTPSQQPFARPAEEACGSLPELIARLRPGVLIGVSGQGGLFTEQVLGAMGEACERPVILPLSNPTRSAEATPEQVWRATGGRALLATGSPFAPVEVGGEARVVSQCNNVNVFPGIGLGACAVKARRISDGMLLAAVRAVGAYPLVTGRLLPPIEQVGEVARAVARAVALTAHEEGLADFDGDPAPLIDQTWWRPHYWSAS
>NZ_CP050994.1|WP_168235593.1|2542878_2544189_-|2-hydroxycarboxylate-transporter-family-protein
MKNLSTSEVQMKGAWSDQQIAGMPMMIFLGLATCVLYAGWNGSLPLGMVGALALMFVLGTLLSELGERIPPIREYLGGGTILAIFGGAALFEYRILPVEAGEVITRFMKEGGFLNFFIASLVTGSVFGMSGALLKNAAMRYLPVILGGVALALLSVGLVGSLMGYGFKNAVLLIGLPIMGGGMGAGAVPLVEILSGPLQMSSADLLSRMVPAVVIANTLAILVGSLLARLGRRYPSLTGNGKLMVKENSQSVADEQAEAPTLQSLGLGLFISSSMFVLGSLLGNFIPMHPFALMILAVAFIKVSGVLPRRYEQAAADWYQFVVSNLTPSLLVGIGVAYTSIPELIGAFSVNYFIMVLTTVVGGALGAALVGRMIGFYPIEAAITGGLCMANMGGTGDVAVLSAAQRMKLMPFAQISSRLGGAVMLILATALISLLA
>NZ_CP050994.1|WP_042040713.1|2544406_2544880_+|transcriptional-regulator-SlyA
MKKDLEMLRELSLAEQLGRLHRLWRTVADIELAPLGLTHPRWTALWKLSRLGGHLSQKTLAEALEIELPSLMRTLGQLEELALIERHCCSQDKRARIVTLTPAGKALLDKIEDRIMEVRRDLLAGISQQELAQFEEIVHRISANALGKIGAQHEERE
>NZ_CP050994.1|WP_106886112.1|2544881_2545937_+|HlyD-family-secretion-protein
MTPDQQFKRWIKWAMACFILVFGYFLLADIKMPLTPQAMATRVVTKMAPQVSGKVVEVAVVNNQHVKQGDLLFVLDPAPFELAVEQARLALDQAEQQNRQLDATLNAAAADFSSLQTQTAQKQREAERIDTLYRRHMVSEQQKDDADSAARTARANLLASQARMEQARVNRGLAGDDNLLLRQARNRLAQAELNLTYSQVHASQDGIITNLQLKPGSVATAGSPLLALVSEQVDVIADFREKSLRNITPQSRALVAFDGEPGRLYPARVASLDAGVSAGQFDANGLLANPIESDRWVRDAQRLRLHLTLDQLPAHLPAGARATVQLLPDNALSALFARGQIRLLSLLHYIY
>NZ_CP050994.1|WP_168235594.1|2545947_2546976_+|DUF2955-domain-containing-protein
MNLWHRPLTANELRQCLRIAFGCTLGFVLCKIFGWSNGVFFTVTPVLLLGMIPVMNGHAARQLIASAAMCGLEVGLLGGLFGSHPGLMTPLVFLLFLYRFAAMSRGSLFLFGANGVLSLSIMLHFASYPGTDLNDLIFSNLWASILSVLIAYLMTALIPDVEARPAPTPSPKAPHRMRHEALLGASIATLSFLVFQLFDLRDSMSAQATTLLVLFPMHWDGALSYARKRAMGTLLGVSFGILGQLVLYDWSGLLLLVTPLLWLGAMLFSHAHVKEASGSGVGFGALTTLGILFGQYLTPGNDLVFSALYRVSSIMFAIVATLLACYLIHRLLNRFEATRFGY
>NZ_CP050994.1|WP_168235595.1|2547461_2548334_+|beta-1,6-N-acetylglucosaminyltransferase
MIAYLILVHRYPGQFKRLFKAIYHHSNHYLIHVDKRSGPELQQEIADFLADYPNAAMLPSKNALWGGYSLVDAELRGIAALLEQNQEWEFFINLSAQDFPLRSQRDIHDFLRDHRGKDFLKVADQRQHRPDTLHRIDHYVTETAQELLCEPVKTRPYLDDVTPYIGNQWMILSRAFCEFVSHSPEVDRFKAFYRHTLIADEGFFQTVIMNTSYQGQIVNDDKRAIDWIPMGDIKLRPRDYTVDDADALQQSEHLFARKFDETIDSDILDILERAMMCPLATPDIRQPVPA

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Crispr_ID: NZ_CP050994_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_12

2549806-2549927

Orphan

Consensus_repeat	Method
CGCCAGGCGTCGAGGTCGTGAATGATCTGGTTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_12

>merge|NZ_CP050994|12|2549806-2549927|CRISPRCasFinder
CGCCAGGCGTCGAGGTCGTGAATGATCTGGTTGCCGCTATCGTCACGCCAGCAGCTGGCAGGGGATCCGGCTCTTATGCTTCCGCTCCCGCCAGGCGTCGAGGTCGTGGATGATCTGGTTGC

>NZ_CP050994|12|12|2549806-2549927|CRISPRCasFinder
CGCCAGGCGTCGAGGTCGTGAATGATCTGGTTGC	CGCTATCGTCACGCCAGCAGCTGGCAGGGGATCCGGCTCTTATGCTTCCGCTCC
CGCCAGGCGTCGAGGTCGTGGATGATCTGGTTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_025327872.1\|2561821_2562436_+\|trimeric-intracellular-cation-channel-family-protein	unknown	unknown	gnl\|CDD\|225415
NZ_CP050994.1\|WP_111909957.1\|2548443_2548803_+\|MliC-family-protein	unknown	unknown	gnl\|CDD\|226411
NZ_CP050994.1\|WP_139746297.1\|2560922_2561687_+\|sulfate-transporter-CysZ	unknown	unknown	gnl\|CDD\|179898
NZ_CP050994.1\|WP_106886104.1\|2556294_2557422_-\|cell-division-protein-ZipA	unknown	unknown	gnl\|CDD\|235124
NZ_CP050994.1\|WP_106886112.1\|2544881_2545937_+\|HlyD-family-secretion-protein	unknown	unknown	gnl\|CDD\|224482
NZ_CP050994.1\|WP_168235599.1\|2557437_2560812_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|274008
NZ_CP050994.1\|WP_168235595.1\|2547461_2548334_+\|beta-1,6-N-acetylglucosaminyltransferase	unknown	unknown	gnl\|CDD\|367100
NZ_CP050994.1\|WP_025327864.1\|2549426_2549597_-\|YqaE/Pmp3-family-membrane-protein	unknown	unknown	gnl\|CDD\|376592
NZ_CP050994.1\|WP_168235598.1\|2554188_2556195_-\|NAD-dependent-DNA-ligase-LigA	unknown	unknown	gnl\|CDD\|236137
NZ_CP050994.1\|WP_042040713.1\|2544406_2544880_+\|transcriptional-regulator-SlyA	unknown	unknown	gnl\|CDD\|179596
NZ_CP050994.1\|WP_106886101.1\|2562528_2562780_-\|DUF3862-domain-containing-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_106886109.1\|2548865_2549261_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367555
NZ_CP050994.1\|WP_106886099.1\|2563535_2565017_-\|L,D-transpeptidase-family-protein	unknown	unknown	gnl\|CDD\|225536
NZ_CP050994.1\|WP_168235592.1\|2541305_2542856_-\|NAD-dependent-malic-enzyme	unknown	unknown	gnl\|CDD\|237414
NZ_CP050994.1\|WP_168235600.1\|2562841_2563387_-\|YcbK-family-protein	unknown	unknown	gnl\|CDD\|283577
NZ_CP050994.1\|WP_168235597.1\|2550604_2552722_-\|anaerobic-ribonucleoside-triphosphate-reductase	unknown	unknown	gnl\|CDD\|236436
NZ_CP050994.1\|WP_168235593.1\|2542878_2544189_-\|2-hydroxycarboxylate-transporter-family-protein	unknown	unknown	gnl\|CDD\|377030
NZ_CP050994.1\|WP_168235594.1\|2545947_2546976_+\|DUF2955-domain-containing-protein	unknown	unknown	gnl\|CDD\|371403
NZ_CP050994.1\|WP_168236564.1\|2553154_2554129_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_042649489.1\|2539025_2539718_-\|response-regulator	unknown	unknown	gnl\|CDD\|226931

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_025327872.1\|2561821_2562436_+\|trimeric-intracellular-cation-channel-family-protein	gnl\|CDD\|225415	COG2860, COG2860, Predicted membrane protein [Function unknown].	2.9371e-70
NZ_CP050994.1\|WP_111909957.1\|2548443_2548803_+\|MliC-family-protein	gnl\|CDD\|226411	COG3895, COG3895, Predicted periplasmic protein [General function prediction only].	7.73196e-20
NZ_CP050994.1\|WP_139746297.1\|2560922_2561687_+\|sulfate-transporter-CysZ	gnl\|CDD\|179898	PRK04949, PRK04949, putative sulfate transport protein CysZ; Validated.	8.30343e-142
NZ_CP050994.1\|WP_106886104.1\|2556294_2557422_-\|cell-division-protein-ZipA	gnl\|CDD\|235124	PRK03427, PRK03427, cell division protein ZipA; Provisional.	2.85619e-63
NZ_CP050994.1\|WP_106886112.1\|2544881_2545937_+\|HlyD-family-secretion-protein	gnl\|CDD\|224482	COG1566, EmrA, Multidrug resistance efflux pump [Defense mechanisms].	1.36431e-66
NZ_CP050994.1\|WP_168235599.1\|2557437_2560812_-\|AAA-family-ATPase	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0
NZ_CP050994.1\|WP_168235595.1\|2547461_2548334_+\|beta-1,6-N-acetylglucosaminyltransferase	gnl\|CDD\|367100	pfam02485, Branch, Core-2/I-Branching enzyme. This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme and core-2 branching enzyme. I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development. Core-2 branching enzyme forms crucial side-chain branches in O-glycans. This is a fmmily of glycosyl-transferases that are Type II membrane proteins that are found in the endoplasmic reticulum (ER) and Golgi apparatus.	1.17078e-39
NZ_CP050994.1\|WP_025327864.1\|2549426_2549597_-\|YqaE/Pmp3-family-membrane-protein	gnl\|CDD\|376592	pfam01679, Pmp3, Proteolipid membrane potential modulator. Pmp3 is an evolutionarily conserved proteolipid in the plasma membrane which, in S. pombe, is transcriptionally regulated by the Spc1 stress MAPK (mitogen-activated protein kinases) pathway. It functions to modulate the membrane potential, particularly to resist high cellular cation concentration. In eukaryotic organisms, stress-activated mitogen-activated protein kinases play crucial roles in transmitting environmental signals that will regulate gene expression for allowing the cell to adapt to cellular stress. Pmp3-like proteins are highly conserved in bacteria, yeast, nematode and plants.	1.10136e-11
NZ_CP050994.1\|WP_168235598.1\|2554188_2556195_-\|NAD-dependent-DNA-ligase-LigA	gnl\|CDD\|236137	PRK07956, ligA, NAD-dependent DNA ligase LigA; Validated.	0
NZ_CP050994.1\|WP_042040713.1\|2544406_2544880_+\|transcriptional-regulator-SlyA	gnl\|CDD\|179596	PRK03573, PRK03573, transcriptional regulator SlyA; Provisional.	3.8264e-33
NZ_CP050994.1\|WP_106886109.1\|2548865_2549261_-\|hypothetical-protein	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	3.82603e-08
NZ_CP050994.1\|WP_106886099.1\|2563535_2565017_-\|L,D-transpeptidase-family-protein	gnl\|CDD\|225536	COG2989, COG2989, Uncharacterized protein conserved in bacteria [Function unknown].	1.82234e-114
NZ_CP050994.1\|WP_168235592.1\|2541305_2542856_-\|NAD-dependent-malic-enzyme	gnl\|CDD\|237414	PRK13529, PRK13529, oxaloacetate-decarboxylating malate dehydrogenase.	0
NZ_CP050994.1\|WP_168235600.1\|2562841_2563387_-\|YcbK-family-protein	gnl\|CDD\|283577	pfam05951, Peptidase_M15_2, Bacterial protein of unknown function (DUF882). This family consists of a series of hypothetical bacterial proteins of unknown function.	2.45676e-71
NZ_CP050994.1\|WP_168235597.1\|2550604_2552722_-\|anaerobic-ribonucleoside-triphosphate-reductase	gnl\|CDD\|236436	PRK09263, PRK09263, anaerobic ribonucleoside triphosphate reductase; Provisional.	0
NZ_CP050994.1\|WP_168235593.1\|2542878_2544189_-\|2-hydroxycarboxylate-transporter-family-protein	gnl\|CDD\|377030	pfam03390, 2HCT, 2-hydroxycarboxylate transporter family. The 2-hydroxycarboxylate transporter family is a family of secondary transporters found exclusively in the bacterial kingdom. They function in the metabolism of the di- and tricarboxylates malate and citrate, mostly in fermentative pathways involving decarboxylation of malate or oxaloacetate.	1.57329e-162
NZ_CP050994.1\|WP_168235594.1\|2545947_2546976_+\|DUF2955-domain-containing-protein	gnl\|CDD\|371403	pfam11168, DUF2955, Protein of unknown function (DUF2955). Some members in this family of proteins with unknown function annotate the proteins as membrane protein. However, this cannot be confirmed.	4.19093e-45
NZ_CP050994.1\|WP_042649489.1\|2539025_2539718_-\|response-regulator	gnl\|CDD\|226931	COG4565, CitB, Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms].	1.25452e-62

>NZ_CP050994.1|WP_025327864.1|2549426_2549597_-|YqaE/Pmp3-family-membrane-protein
MNNLLKILLAIFLPPVCAFIQVGLSLHFFINIVLTLLGGLPGMVHALWLVVSDKRA
>NZ_CP050994.1|WP_106886109.1|2548865_2549261_-|hypothetical-protein
MGLKIVLLGAALMLGGCASPSPTVKLNQPPREVSEEELCLYWVQEGEVTQFNLRLKRPMKAPVEGFVDIRYLIDSNGNLFSPEILAAEPAGMLELAALTALSKMRYRVAEQNPEAIPVQVVQRFRLKGTPQ
>NZ_CP050994.1|WP_111909957.1|2548443_2548803_+|MliC-family-protein
MKQANLALLGLGTLTLLSGCDLGAGKLGVTGGDPVTYLCEQNQKVQVRYFSLSDESLNFVKLSLPDGKDYTLPQAVSASGARYTDDHEVVWWNKGKEGFVEMRDEAGEWQSRYNDCKEQ
>NZ_CP050994.1|WP_168235595.1|2547461_2548334_+|beta-1,6-N-acetylglucosaminyltransferase
MIAYLILVHRYPGQFKRLFKAIYHHSNHYLIHVDKRSGPELQQEIADFLADYPNAAMLPSKNALWGGYSLVDAELRGIAALLEQNQEWEFFINLSAQDFPLRSQRDIHDFLRDHRGKDFLKVADQRQHRPDTLHRIDHYVTETAQELLCEPVKTRPYLDDVTPYIGNQWMILSRAFCEFVSHSPEVDRFKAFYRHTLIADEGFFQTVIMNTSYQGQIVNDDKRAIDWIPMGDIKLRPRDYTVDDADALQQSEHLFARKFDETIDSDILDILERAMMCPLATPDIRQPVPA
>NZ_CP050994.1|WP_168235594.1|2545947_2546976_+|DUF2955-domain-containing-protein
MNLWHRPLTANELRQCLRIAFGCTLGFVLCKIFGWSNGVFFTVTPVLLLGMIPVMNGHAARQLIASAAMCGLEVGLLGGLFGSHPGLMTPLVFLLFLYRFAAMSRGSLFLFGANGVLSLSIMLHFASYPGTDLNDLIFSNLWASILSVLIAYLMTALIPDVEARPAPTPSPKAPHRMRHEALLGASIATLSFLVFQLFDLRDSMSAQATTLLVLFPMHWDGALSYARKRAMGTLLGVSFGILGQLVLYDWSGLLLLVTPLLWLGAMLFSHAHVKEASGSGVGFGALTTLGILFGQYLTPGNDLVFSALYRVSSIMFAIVATLLACYLIHRLLNRFEATRFGY
>NZ_CP050994.1|WP_106886112.1|2544881_2545937_+|HlyD-family-secretion-protein
MTPDQQFKRWIKWAMACFILVFGYFLLADIKMPLTPQAMATRVVTKMAPQVSGKVVEVAVVNNQHVKQGDLLFVLDPAPFELAVEQARLALDQAEQQNRQLDATLNAAAADFSSLQTQTAQKQREAERIDTLYRRHMVSEQQKDDADSAARTARANLLASQARMEQARVNRGLAGDDNLLLRQARNRLAQAELNLTYSQVHASQDGIITNLQLKPGSVATAGSPLLALVSEQVDVIADFREKSLRNITPQSRALVAFDGEPGRLYPARVASLDAGVSAGQFDANGLLANPIESDRWVRDAQRLRLHLTLDQLPAHLPAGARATVQLLPDNALSALFARGQIRLLSLLHYIY
>NZ_CP050994.1|WP_042040713.1|2544406_2544880_+|transcriptional-regulator-SlyA
MKKDLEMLRELSLAEQLGRLHRLWRTVADIELAPLGLTHPRWTALWKLSRLGGHLSQKTLAEALEIELPSLMRTLGQLEELALIERHCCSQDKRARIVTLTPAGKALLDKIEDRIMEVRRDLLAGISQQELAQFEEIVHRISANALGKIGAQHEERE
>NZ_CP050994.1|WP_168235593.1|2542878_2544189_-|2-hydroxycarboxylate-transporter-family-protein
MKNLSTSEVQMKGAWSDQQIAGMPMMIFLGLATCVLYAGWNGSLPLGMVGALALMFVLGTLLSELGERIPPIREYLGGGTILAIFGGAALFEYRILPVEAGEVITRFMKEGGFLNFFIASLVTGSVFGMSGALLKNAAMRYLPVILGGVALALLSVGLVGSLMGYGFKNAVLLIGLPIMGGGMGAGAVPLVEILSGPLQMSSADLLSRMVPAVVIANTLAILVGSLLARLGRRYPSLTGNGKLMVKENSQSVADEQAEAPTLQSLGLGLFISSSMFVLGSLLGNFIPMHPFALMILAVAFIKVSGVLPRRYEQAAADWYQFVVSNLTPSLLVGIGVAYTSIPELIGAFSVNYFIMVLTTVVGGALGAALVGRMIGFYPIEAAITGGLCMANMGGTGDVAVLSAAQRMKLMPFAQISSRLGGAVMLILATALISLLA
>NZ_CP050994.1|WP_168235592.1|2541305_2542856_-|NAD-dependent-malic-enzyme
MNDIMMGTSLPYAERKRQGLMGRMPHKEESLSQQRRRIYRLVSAMQSPFDQHLLLRQLQEDNPVLFYDLVRHHLPELLPIIYTPVVGEACQRHSDLYLRSHGLYLSWHDRDELDAIFAAVEQEVDVIVISDGERVLGLGDLGIGGMGICIGKLALYSAAGGINPARTLPLCVDVGTNNPALLEDDSYLGWQAPRIDGETYYHFMDKVVAAIHKRWPQVVLQFEDFAGKHAANLLARYRDELCMFNDDIQGTAAVASACVLAGLQQAGSTLADTPVLIVGAGSAGCGIAAMLARLAGSPERVQLFDQDGLVCLDRANLTPSQQPFARPAEEACGSLPELIARLRPGVLIGVSGQGGLFTEQVLGAMGEACERPVILPLSNPTRSAEATPEQVWRATGGRALLATGSPFAPVEVGGEARVVSQCNNVNVFPGIGLGACAVKARRISDGMLLAAVRAVGAYPLVTGRLLPPIEQVGEVARAVARAVALTAHEEGLADFDGDPAPLIDQTWWRPHYWSAS
>NZ_CP050994.1|WP_042649489.1|2539025_2539718_-|response-regulator
MKPIFTLVIEDDERIGAILAELISSTPGYSLLGRAESLAQADLMMRATEPQLLVVDISLPDGSGLEWVNRLRSHNREVFVVMVTASCDVETIQQALNLGVQDYIIKPLRLFRIQQSLDEILTLHRRLCERGLLEQSDLDRLMGKGRIQPREVRDTPKGIDAITLRQVLELLAGEPDTAFSTDTVALRLSLSRTTARRYLEFLESEDKLDVDLNYGQRGRPERRYHWRRSS
>NZ_CP050994.1|WP_168235597.1|2550604_2552722_-|anaerobic-ribonucleoside-triphosphate-reductase
MKPVVIKRDGCRAPFNGQLIAEAVSRAAEAVNQANPALAERISSAVSQELEGRGEVDIHEIQNRVENHLMASDDKAIARAYIEYRHDRDQAREARGRLAQEIRGLVEQTNAALLNENANKDSKVIPTQRDLLAGIVAKHYAISHMLPREVVQAHESGDLHFHDLDYSPFFPMFNCMLIDLQGMLTHGFKMGNAEIDTPKSISTATAVTAQIIAQVASHIYGGTTINRIDEVLAPYVTISWQKHREVAEEWGIADVDAYAMARTEKECYDAFQSLEYEVNTLHTANGQTPFVTFGFGLGDSWESRMIQGAILGNRIAGLGKNKKTAVFPKLVFAIKDGLNHKPGDPNYDIKQLALECASKRMYPDILNHDQVVKVTGSFKTPMGCRSFLGAYEENGELIHEGRNNIGVVSLNLPRIALKSRDEADFWDKLDAALRVAKQALMYRIERLDGVKARVAPILYMEGACGVRLKADDNVSEIFKNGRASISLGYIGVHETINALFGTDTHLFDSEVLREKAIAIIARLKAATDEWKEETGYGFSLYSTPSENLCTRFCRIDAKEFGVVAGVTDKGYYTNSFHLDVEKQVNPYDKLDFEAPYPPIASGGFICYGEYPNIQHNLEALENVWDYSYDKVPYYGTNTPIDECYDCGFTGEFECTSKGFTCPRCGNHDPAKVSVTRRVCGYLGSPDARPFNAGKQEEVKRRVKHM
>NZ_CP050994.1|WP_168236564.1|2553154_2554129_+|hypothetical-protein
MNVTKVLLLIALFPLQLMAAEILVISSYHQANLWDQSYSAGLKKHLKGEHHISHFYLDTKRQPHQTREQLVSQGLAAYQAHKPALVVLGDDNAINALARPIAALGTPVVFLGMNENPRPKGLVGHPQITGVLERPLLKRNISEMSQLMGRLGKALVLFDASEVSRTAIEDEFTTPDEQRVGQTRVNNQQIDDYRRWQEVVLASRQNGYEAIFLGLYHTLKDEQGLHVSEQQVLAWTSANSPVPLFGFWEFAVGPHRTIGGLVLDGHTQGEKAAELANAILAGTAPQALSPRAAQRGEYLFSKSELARWQLEAPSRWQGRVTYVD
>NZ_CP050994.1|WP_168235598.1|2554188_2556195_-|NAD-dependent-DNA-ligase-LigA
MSDILSRHRQLCELLTEYGHQYYVLDNPTVPDAEYDRLMRELIALETEHPELKTPASPSVRVGGQPLSAFSQVRHEIPMLSLDNVFSAEELQAFEQRMRDRLKREISFTFCCEPKLDGLAVSLLYVDGQLMQAATRGDGTTGEEITENVRTIKAIPLVLRGSGWPARLEVRGEVFMPKAGFEAMNAKALAAGEKVFVNPRNAAAGSLRQLDSRITASRPLSFYAYGVGVGGDELGNSHYRRLTQLNAWGLPLSPEVKLKEGAAGCQAFHDDILARRGELPYEIDGVVYKVDDIGLQQELGFVARAPRWATAHKFPAEEEMTLLENVEFQVGRTGAVTPVAKLKPVFVGGVTVSNATLHNADEIERLGVMIGDTVIVRRAGDVIPQIVAVVEAQRPADARAILFPTQCPVCGSAVERLEGEAVTRCSGGLFCEAQRKEAIKHFAARRAMDVDGLGDKIVEQLVDKGLVKTPADLFSLNAIQLAGLERMGQKSALNLVAAIDKARSTTLPRFLFALGIREVGEATALNLANHFLTLDALRTASVEQLLEVADVGDIVAKHVYYFLRQPHNIEVLEALLAAGIHWPAIEKKEASDQPFAGKTFVLTGTLTTLSRNDAKAALQALGAKVAGSVSAKTDVLVAGEAAGSKLAKAQELGITVWTEAELQAAIQP
>NZ_CP050994.1|WP_106886104.1|2556294_2557422_-|cell-division-protein-ZipA
MQELRYILVALGGIAIAALLIHGLWSNRKNRQAPIKEKPLGRMESKSRDRDSDAFDSDGIGQVRVVSGGRRAEPKLRSDEAHQPEPRRAATVPAFDDDEDDELPPPVVRKPAPRPVTPPPVYEEEDEYEEPSAEPVEEVPAAPVRKPAQVIRRTPVHRSRPQREPMMQPLDDEPLVEPAYAQAPTFGAREPAPQQQARYAQPVSAYEEPDYDDEPAYEEPVQVAEPVQELPPVEKIWQDVYVINLMARPGHDLQGATLLSSLLALGFKFGEMDIFHRHEDLNGKGEVLFSMINMVKPGTFNPYRMEQFSTPGVSLFMQLPLRSNAAFAFEHMLQAADQLASDLDAMLTDASRSPLSDDDIARYRHELAAYEASRD
>NZ_CP050994.1|WP_168235599.1|2557437_2560812_-|AAA-family-ATPase
MRLKLIKLAGFKSFVEPTRIELSADMTAVVGPNGCGKSNVIDAVRWVLGESSARHLRGENMTDVIFNGSINRSPHGRASVELVFDNPHNRVPGEFGRYTEISVRREVLRDGSNHYQINGQKCRRKDVTDLFLGTGLGPRSYAIIEQGTVSRLVESRPADLKLFMEEAAGVSRYKERRRETEQRIRHTQENLERLGDIRGELGSRLEHLKSQAETAERYKQLKGRSRAARAELIGSELWALETRLGEAKSELAQAEQALAALDAKRTQDEGRHVTLSVARQEAQAEQASRQQQIFLGGQAIARLEQQQLHQTELGRDWQVRRQALGERIDGIKAQLASQQEQQAEGVLQGELESARLEQCEQLLADQQAVRLAAGERLELARQRQQQWQQQLGQAQGRLNQTRTQVNGLQELQAKTRLARLKLADEQAGPLGGEGESLQPALDALSAELALSRARHGELEAQWQASVASHEALKGERDRQGGLLRELGARLTTLNQMLGEQMQGATLADRLQVAPEWAQALDKVLGRWLTAQPGDQCNLEQGGLWIGPAHPAVPGTLAARLEGDHIPAFLSVIWLADDREAALARQSSLLAGESVLTPVGEWFGPNWADLGQGGALGTLALLGERERLHTELTAGEQALVQLDAQLKAADTDRAHLHSAFEASQRTLREQEQQWQQLREAWSLQQGQRQERLLRLGQLGEELIRLDKEQAEEAERLAAAQQRLELEEAHLAELQEQGEPLAEALLLAQEGVTSAERVLEEARARREQQQASCQRWQLAQQNLAQLIALREQELARLGLELAELKGPDAQAVQDISPLLAEQRNLEAQQLACHQRLAELERQLTELEQARSADHKQLVTLQEKLAQLRLERERNLTRRQGLHEQFEELGVRLVDLDQAVLIAADRGKLRQEIQTLETQVEALGAINLAALEEYEEAKTRASYLENQCQDLEQALETLSQAIKRIDKETQIRFRDTFDKVNEDLKSLFPKVFGGGSAWLELTSDDLLEAGVSIMARPPGKKNATIALLSGGEKALTALALVFAIFRLNPAPFCLLDEVDAPLDEVNVGRFCSLVKEMSSTVQFVYISHNKVSMEMAEQLIGVTMQEPGVSRIVSVDIGEAVALAEQN
>NZ_CP050994.1|WP_139746297.1|2560922_2561687_+|sulfate-transporter-CysZ
MSQSPHMVKDSVSGADYFLRGFSLIRQPGIRTFVLIPLLVNFVLFAGAFYALLLQLDGLFAWLHQQIPAWLSWLDYLLWPIALITILVVFSFIFSSVINWIAAPFNGLLAEKVEQILTGEAVSDTGMLDVVKDVPRTFSREWTKLKYYLPKAIGCLILFLIPVVGQTLAPVLWFLFSAWMMAIQYIDYPFDNHKISFITMRDALKQRRGKCLSFGALVTLFSAIPVVNLFVMPVAICGATAMWVDQYRSEQLRR
>NZ_CP050994.1|WP_025327872.1|2561821_2562436_+|trimeric-intracellular-cation-channel-family-protein
MLHALFLLGLVAEGMTGALAAGRRRMDLFGVVIIASATAIGGGTIRDVLLGHYPLLWVEHPEYVVLVAGAAMVGVISAPLMRYLGKLFLALDALGLVVFSIFGAARALEMGHGAGIACIMAVVTGVFGGVLRDLLCQRIPLVFKRELYAAVSLVTAALYCFALDQGLPNDWAAFGAIGIGFVLRLLAVRFKWGLPTFNYQYATH
>NZ_CP050994.1|WP_106886101.1|2562528_2562780_-|DUF3862-domain-containing-protein
MKHILLGGLIALLLTGCSKLNRENYDKLKMGITYAEASAILGKAERCDDALGTTSCVWGGDGKNIKIRFIADKATFFSSEGIN
>NZ_CP050994.1|WP_168235600.1|2562841_2563387_-|YcbK-family-protein
MLEQEISRRRLLLGAGCLMGASLLSFPAAASRSTTGRELSFFNLNTGERVNASYWENGRYLNDGLAELNHIFRDYRLNEVFNIDRKLFDQLFLLQHKLGRKGEIQLISGYRSPATNRQKRQHSRGVAKHSYHTLGQAVDVRIPGVQLAHLRKAALNLKVGGVGYYPSDNFVHLDTGPVRSW
>NZ_CP050994.1|WP_106886099.1|2563535_2565017_-|L,D-transpeptidase-family-protein
MGKKYWLALANLIWLGCWPAGMVHASTEQMVVASPSIQHDWYQNSTAEQARHELELQLQEAVLAQLHPDFYRLWQQLQKTPADRRGALYDEAFGKLARFQQAWRAMDLVAREQMQTLKLDLTKPLAHEPLGDNLLDQVKQLRPQVAEYEAVRDEVRKLLAMPMAKHWPTLDMPTLRAGESATELGQIRSILNELGDGAPTHQDSLYDADTEQAIKQFQRRHGLTADGIIGRQTRSWLNTGPQVRASLLLRNLWRRDLVDHLAGRYVLVNIPDYRLSVVESGSEVFTSRVIVGKEQRATPILASEIRSIVLNPAWHVPRSILSKDILPKLGRDPAYLDREQFEVIDGEGNPVQFSEDGWHHALASGFPYRLRQKPGDHNALGRYKFYLPNNDAIYLHSTPRKALFEQGARAFSSGCIRVEHADDLAELLLADSRYQPDKVASILKETQTKWLPLTTPIPVFTVYWSSWIDEEGRQQLRNDIYGFDRVSFQSRLL

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Crispr_ID: NZ_CP050994_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_13

2710523-2710633

Orphan

Consensus_repeat	Method
AGCCCGTAACGCAGCTTGAGCGTATCGGGATG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_13

>merge|NZ_CP050994|13|2710523-2710633|CRISPRCasFinder
AGCCCGTAACGCAGCTTGAGCGTATCGGGATGCGGGTCTCTGGATAGACCTGAACCCACGTAATCAGCCCAATATTCAAAGCCCGTAGCGCAGCTTGAGCGTATCGGGATG

>NZ_CP050994|13|13|2710523-2710633|CRISPRCasFinder
AGCCCGTAACGCAGCTTGAGCGTATCGGGATG	CGGGTCTCTGGATAGACCTGAACCCACGTAATCAGCCCAATATTCAA
AGCCCGTAGCGCAGCTTGAGCGTATCGGGATG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_168235660.1\|2717924_2719079_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379855
NZ_CP050994.1\|WP_168235658.1\|2714147_2714744_-\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|319790
NZ_CP050994.1\|WP_163153659.1\|2706968_2707703_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|180399
NZ_CP050994.1\|WP_163148776.1\|2703222_2703702_-\|DUF2878-family-protein	unknown	unknown	gnl\|CDD\|378555
NZ_CP050994.1\|WP_168235655.1\|2709562_2710450_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133379
NZ_CP050994.1\|WP_168235657.1\|2712527_2713082_-\|DUF3157-family-protein	unknown	unknown	gnl\|CDD\|371487
NZ_CP050994.1\|WP_168235662.1\|2722774_2724076_-\|TolC-family-protein	unknown	unknown	gnl\|CDD\|273829
NZ_CP050994.1\|WP_168235649.1\|2702508_2703051_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|374318
NZ_CP050994.1\|WP_025327995.1\|2703007_2703226_-\|TIGR02450-family-Trp-rich-protein	unknown	unknown	gnl\|CDD\|370527
NZ_CP050994.1\|WP_111909878.1\|2715069_2716242_+\|prephenate-dehydratase	unknown	unknown	gnl\|CDD\|182594
NZ_CP050994.1\|WP_168235650.1\|2703704_2704961_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|225139
NZ_CP050994.1\|WP_168235659.1\|2716579_2717005_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225563
NZ_CP050994.1\|WP_168235652.1\|2705712_2706972_-\|NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|225459
NZ_CP050994.1\|WP_106886012.1\|2717018_2717639_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379995
NZ_CP050994.1\|WP_168235653.1\|2707699_2708128_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|378915
NZ_CP050994.1\|WP_168235651.1\|2704960_2705716_-\|DUF1365-domain-containing-protein	unknown	unknown	gnl\|CDD\|377778
NZ_CP050994.1\|WP_168235656.1\|2711715_2712345_-\|autotransporter	unknown	unknown	unknown
NZ_CP050994.1\|WP_168235654.1\|2708129_2709566_-\|deoxyribodipyrimidine-photo-lyase	unknown	unknown	gnl\|CDD\|236734
NZ_CP050994.1\|WP_168236566.1\|2720613_2722746_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|274550
NZ_CP050994.1\|WP_168235661.1\|2719406_2720624_-\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|130902

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_168235660.1\|2717924_2719079_+\|hypothetical-protein	gnl\|CDD\|379855	pfam16539, FlgT_M, Flagellar assembly protein T, middle domain. FlgT_M is the middle region of a family of flagellar proteins that make up part of the basal body of the flagellum. The flagellum is a large macromolecular assembly composed of three major parts: the basal body, the hook, and the filament. The basal body has two unique ring structures, the T ring and the H ring. FlgT is required to form and stabilize both ring structures. FlgT-N and FlgT-M are thought to be involved in the H-ring and the T-ring formation, respectively. and FlgT-M is also required for the stable association of FlgT with the basal body.	3.24672e-39
NZ_CP050994.1\|WP_168235658.1\|2714147_2714744_-\|HAD-family-phosphatase	gnl\|CDD\|319790	cd02603, HAD_sEH-N_like, N-terminal lipase phosphatase domain of human soluble epoxide hydrolase, Escherichia coli YihX/HAD4 alpha-D-glucose 1-phosphate phosphatase, and related domains, may be inactive. This family includes the N-terminal phosphatase domain of human soluble epoxide hydrolase (sEH). sEH is a bifunctional enzyme with two distinct enzyme activities, the C-terminal domain has epoxide hydrolysis activity and the N-terminal domain (Ntermphos), which belongs to this family, has lipid phosphatase activity. The latter prefers mono-phosphate esters, and lysophosphatidic acids (LPAs) are the best natural substrates found to date. In addition this family includes Gallus gallus sEH and Xenopus sEH which appears to lack phosphatase activity, and Escherichia coli YihX/HAD4 which selectively hydrolyzes alpha-Glucose-1-P, phosphatase, has significant phosphatase activity against pyridoxal phosphate, and has low beta phosphoglucomutase activity. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	8.79035e-47
NZ_CP050994.1\|WP_163153659.1\|2706968_2707703_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|180399	PRK06101, PRK06101, SDR family oxidoreductase.	1.9897e-82
NZ_CP050994.1\|WP_163148776.1\|2703222_2703702_-\|DUF2878-family-protein	gnl\|CDD\|378555	pfam11086, DUF2878, Protein of unknown function (DUF2878). This bacterial family of proteins has no known function. Some members annotate the proteins as the permease component of a Mn2+/Zn2+ transport system however this cannot be confirmed.	1.02333e-18
NZ_CP050994.1\|WP_168235655.1\|2709562_2710450_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133379	cd01104, HTH_MlrA-CarA, Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA. Helix-turn-helix (HTH) transcription regulator MlrA (merR-like regulator A), N-terminal domain. The MlrA protein, also known as YehV, has been shown to control cell-cell aggregation by co-regulating the expression of curli and extracellular matrix production in Escherichia coli and Salmonella typhimurium. Its close homolog, CarA from Myxococcus xanthus, is involved in activation of the carotenoid biosynthesis genes by light. These proteins belong to the MerR superfamily of transcription regulators that promote expression of several stress regulon genes by reconfiguring the spacer between the -35 and -10 promoter elements. Their conserved N-terminal domains contain predicted HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules. Many MlrA- and CarA-like proteins in this group appear to lack the long dimerization helix seen in the N-terminal domains of typical MerR-like proteins.	1.36395e-26
NZ_CP050994.1\|WP_168235657.1\|2712527_2713082_-\|DUF3157-family-protein	gnl\|CDD\|371487	pfam11355, DUF3157, Protein of unknown function (DUF3157). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	9.38038e-35
NZ_CP050994.1\|WP_168235649.1\|2702508_2703051_-\|hypothetical-protein	gnl\|CDD\|374318	pfam16036, Chalcone_3, Chalcone isomerase-like. Chalcone_3 is a family of largely bacterial members.	0.00174785
NZ_CP050994.1\|WP_025327995.1\|2703007_2703226_-\|TIGR02450-family-Trp-rich-protein	gnl\|CDD\|370527	pfam09493, DUF2389, Tryptophan-rich protein (DUF2389). Members of this family are small hypothetical proteins of 60 to 100 residues from Cyanobacteria and some Proteobacteria. Prochlorococcus marinus strains have two members, other species one only. Interestingly, of the eight most conserved residues, four are aromatic and three are invariant tryptophans. It appears all species that encode this protein can synthesize tryptophan de novo.	8.04473e-12
NZ_CP050994.1\|WP_111909878.1\|2715069_2716242_+\|prephenate-dehydratase	gnl\|CDD\|182594	PRK10622, pheA, bifunctional chorismate mutase/prephenate dehydratase; Provisional.	0
NZ_CP050994.1\|WP_168235650.1\|2703704_2704961_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|225139	COG2230, Cfa, Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane].	4.60028e-106
NZ_CP050994.1\|WP_168235659.1\|2716579_2717005_-\|hypothetical-protein	gnl\|CDD\|225563	COG3018, COG3018, Uncharacterized protein conserved in bacteria [Function unknown].	1.97678e-13
NZ_CP050994.1\|WP_168235652.1\|2705712_2706972_-\|NAD(P)-binding-protein	gnl\|CDD\|225459	COG2907, COG2907, Predicted NAD/FAD-binding protein [General function prediction only].	6.34e-163
NZ_CP050994.1\|WP_106886012.1\|2717018_2717639_-\|hypothetical-protein	gnl\|CDD\|379995	pfam17680, FlgO, FlgO protein. This entry represents the FlgO protein. Mutation of this protein in Vibrio cholerae has been shown to reduce motility. FlgO is an outer membrane protein that localizes throughout the membrane and not at the flagellar pole. Although FlgO and FlgP do not specifically localize to the flagellum, they are required for flagellar stability. Proteins in this family mostly contain an N-terminal lipoprotein attachment motif.	1.03518e-46
NZ_CP050994.1\|WP_168235653.1\|2707699_2708128_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	1.08959e-13
NZ_CP050994.1\|WP_168235651.1\|2704960_2705716_-\|DUF1365-domain-containing-protein	gnl\|CDD\|377778	pfam07103, DUF1365, Protein of unknown function (DUF1365). This family consists of several bacterial and plant proteins of around 250 residues in length. The function of this family is unknown.	1.6571e-101
NZ_CP050994.1\|WP_168235662.1\|2722774_2724076_-\|TolC-family-protein	gnl\|CDD\|273829	TIGR01844, Proteases_secretion_protein_PrtF, type I secretion outer membrane protein, TolC family. Members of this model are outer membrane proteins from the TolC subfamily within the RND (Resistance-Nodulation-cell Division) efflux systems. These proteins, unlike the NodT subfamily, appear not to be lipoproteins. All are believed to participate in type I protein secretion, an ABC transporter system for protein secretion without cleavage of a signal sequence, although they may, like TolC, participate also in the efflux of smaller molecules as well. This family includes the well-documented examples TolC (E. coli), PrtF (Erwinia), and AprF (Pseudomonas aeruginosa). [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Porins].	2.85437e-27
NZ_CP050994.1\|WP_168235654.1\|2708129_2709566_-\|deoxyribodipyrimidine-photo-lyase	gnl\|CDD\|236734	PRK10674, PRK10674, deoxyribodipyrimidine photolyase; Provisional.	0
NZ_CP050994.1\|WP_168236566.1\|2720613_2722746_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|274550	TIGR03375, type_I_sec_LssB, type I secretion system ATPase, LssB family. Type I protein secretion is a system in some Gram-negative bacteria to export proteins (often proteases) across both inner and outer membranes to the extracellular medium. This is one of three proteins of the type I secretion apparatus. Targeted proteins are not cleaved at the N-terminus, but rather carry signals located toward the extreme C-terminus to direct type I secretion. This model is related to models TIGR01842 and TIGR01846, and to bacteriocin ABC transporters that cleave their substrates during export. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	0
NZ_CP050994.1\|WP_168235661.1\|2719406_2720624_-\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|130902	TIGR01843, Hemolysin_secretion_protein_D_plasmid, type I secretion membrane fusion protein, HlyD family. Type I secretion is an ABC transport process that exports proteins, without cleavage of any signal sequence, from the cytosol to extracellular medium across both inner and outer membranes. The secretion signal is found in the C-terminus of the transported protein. This model represents the adaptor protein between the ATP-binding cassette (ABC) protein of the inner membrane and the outer membrane protein, and is called the membrane fusion protein. This model selects a subfamily closely related to HlyD; it is defined narrowly and excludes, for example, colicin V secretion protein CvaA and multidrug efflux proteins. [Protein fate, Protein and peptide secretion and trafficking].	3.09311e-88

>NZ_CP050994.1|WP_168235655.1|2709562_2710450_-|MerR-family-transcriptional-regulator
MSDLPQDDAAKPDEGIYPIREVSRLTGVNAVTLRAWQRRYGLVQPARTDKGHRLYSEQDIRQIGEILSWLERGVSIGQVKGLLSEPQFQPVSDHWQQTLEQFSQALLAFNQRKVEAELNDLLASYPFELVRSRVLQPLVERLLGLWRERPDGELLQQVWLGWLHTRFARHLIEQEKGVPVTLASWGQVGPLDLVWAAYELIGQGYEVQLLGAVEPRHVALLEGRAATPWRVLLGAGLGKPALAADWPAGTRLFGELGRLYDADWLAAHGWRATLAEVMADKPAARGLSGRGSKKS
>NZ_CP050994.1|WP_168235654.1|2708129_2709566_-|deoxyribodipyrimidine-photo-lyase
MRLVWFRNDLRLADNPALRSCCGNAGADEEPVAALFVISPTQWRQHKMAPIRQRFILAQVDALGLELAALGIELHLLRVETFAETPAALASLCRELGVTRLYANQAIEIDEQRRDLTVSAMLAEQEVSCHWLNGCCVLPPGRVLTGSREMFKVFTPFSRAWLKALDEDGFVIHRAPAPRGQPLPWQPLAERAFIDEALGETTPDPRWPVGEAEALRRLHAFLDQGVLDYGETRDFPAMAGTSVLSPYLAAGIISPRQCVAALQQRLGGRPQSKAQPGFVWLNELIWREFYRHLLVLVPSLSMNRPFKPETAALPWSWDPDAFAAWCEGRTGYPIVDAAMRCLNATGWMHNRLRMIVASFLTKDLHIHWRLGEDYFMSRLIDGDLAANNGGWQWAAGTGADAAPYFRVFNPTTQGQRFDPQGDFIRTWVSELADLPATYVHQPHDWLRLKGRQCYPAPMVDHAVARVRAIEMFRDLEKK
>NZ_CP050994.1|WP_168235653.1|2707699_2708128_-|nuclear-transport-factor-2-family-protein
MNDALAHFIVLYLQLDKHQLHRLPEIYADQVVFIDPAHRIEGLAALTRYFSSLYGRLKECRFEITSRQQQGNEAWLSWVMIFAHPRIAGGRPVRVEGATRLQFDAWGKVCLHRDYFDLGAMLYEQLPLLGPVVRTIKGRLGT
>NZ_CP050994.1|WP_163153659.1|2706968_2707703_-|SDR-family-NAD(P)-dependent-oxidoreductase
MSGRVLITGATSGIGRQLALDYRRSGWQVWGCGRDGERLQALAHEGITPLQFDARDSAAMAEVAAGLPRLDLLILNAGNCEYMDVAEGFDSALFARVIETNLVATGHTLAAFLPRLASGSRLAIVSSSVSWLPLPRAEAYGASKAALDYLAATLRLDLAALGIGVTLIRPGFVQTPLTAKNDFPMPCLVTVEEASRAIMGGLAAGRHQIHFPRRFIWLLRLLGALPTGLWLRLGRTLISKGSPS
>NZ_CP050994.1|WP_168235652.1|2705712_2706972_-|NAD(P)-binding-protein
MKKKIAIIGSGISGLSAGFLLHKLHDITLFEAAPLLGGHTATVDVSLAGRSYAIDTGFIVFNDRTYPNFLKLLERIGVARQPTEMSFSVKSPQGLEYNGHNLDTLFAQRSNLLSPRFYRFVAEILRFNREARAWLAELGRHGGGSEPTLGDFLQLGEFSDYFARHYILPMGAAIWSSTLADMRAFPLGFFLRFFANHGLLDVANRPQWYVIPGGSREYIGPLTAGWLPRIRLACPVQGIRRTAEGVLVQSGYGEEQFDEVILACHSDQALALLTDASEGEQAILGDMAYQANDVWLHTDVSCLPARQKAWASWNYQLGDDDEARPLVSYNMNILQGISSPQPFCVSLNPQGRVDESKVLRRFVYHHPVFNQASIAAQQRRAEICGRQHTHFCGAYWYNGFHEDGARSALDVASRFGASL
>NZ_CP050994.1|WP_168235651.1|2704960_2705716_-|DUF1365-domain-containing-protein
MKAAGDTMDTISAIWQGSVRHRRFAPRSHAFSYGLFMLGLDLDELPGLSQGRWFGVERAGLLSFRRSDYLSGSEGSLKQAVWDKVAALGGSAEPGGRVLLLGNVRCLGFYFSPVNFYFCYREGEARYLLAEVSNTPWNERHYYLLDLAALAPHDKDFHVSPFMGLAMRYHWRIRAPARETLIHIESHPRSGEAKLFDATLALRREPLSRQGLVALLARWPWMTLKVLLGIYWQALRLFIKRTPIFSHPESR
>NZ_CP050994.1|WP_168235650.1|2703704_2704961_-|class-I-SAM-dependent-methyltransferase
MELAQSTLSASFIDKGARQLLLSLLGRLEQGQLLLRDGNERHSFGVAGTDLHAEVIVQDPAFYRRLLLGGSIAAGETWVEGLWTSPDPVALVRLLARNLTLLDTLERRLGWLSFPFNKVRHWLNRNTLAGSRSNIAAHYDLGNTLYQGFLDSHMQYSSAIYPSAEATLEQGQQAKLRTICERLELRPEDHLLEIGTGWGGLAVYAARHYGCRVTTTTISQAQHDYAKEWIAREGLGDRITLLLEDYRKLEGSFDKLVSIEMIEAVGHAFLPDYFRQLSRLLRPGGRLLIQAITIADQRHAQYVRGVDFIQRYIFPGGCLPSVSQMAGLLARETDMQLVRLHDHGHHYARTLAHWCERFLALAPELPRLGYSQDFIRLWHFYFAYCEGGFWERAISLVQLEAAKPGPLGWSGDLPVSSH
>NZ_CP050994.1|WP_163148776.1|2703222_2703702_-|DUF2878-family-protein
MWQWAHLLGFNLYWLLAVKWQQPGPLLLMLLLHFLFSPRRRQDWRLIPVALAGCLLDILLWLLGLFQFPSGFPLWLLLLWCGFALTLSHGLRWLRPLPRWQQALFGMVGGASSYVAGAAMGAVHLPWGIWISTALLAVIWMWWLPVLLWVTVTLEGEPR
>NZ_CP050994.1|WP_025327995.1|2703007_2703226_-|TIGR02450-family-Trp-rich-protein
MNTFSTDALLFSKWTKESQYELADRFYLVVACQRDARGQLASVVMQDINTLQEQEMDWHELEDPAHWHMGWN
>NZ_CP050994.1|WP_168235649.1|2702508_2703051_-|hypothetical-protein
MNWKIPPIGTWGGISTLLAALTLLVATAVQASAAPWQQLRPVGQGEMSWLWFKLYDATLYSESGRYEPGRYPQALTLTYARAIEREDLLSATAAEWQRLGLGSETDRERWLGRLAALWPDVGAGDRLTFYVDSAGAGHFWWQDKPLGSLADPQFSAAFLAIWLADNSRDPALTRRLRGQP
>NZ_CP050994.1|WP_168235656.1|2711715_2712345_-|autotransporter
MQKLALSVLVLACLSSTSVLAQDAFSYAKGAATWAHTKSDYVGGKDSNNRDFGGLSLDLSKSFGSNFYGRFGSEYSSRNSGNDSMAISNLGMGVFTPLSTGLNLYGEAGLMGYSMERELASNVNDSGWDNITRKSSGSLYGEVGLRYDIGAVELSTGYRYANMTDDMHDFKAGAAYKVSQNLALTADYTYRNWDLQKGSITSLGVKYSF
>NZ_CP050994.1|WP_168235657.1|2712527_2713082_-|DUF3157-family-protein
MKPLSRLLLALCLSPMLAQAAPLTQVTLADGRQVQLNDDFTWEYLLVKPAEASPGKTVTASVAAPVLTEQALANPDLLAQATRDGITVTLNQVEGEDPLRLQFMVSNTGSRNVVRVNGSLTLFSAEGVQLSTQPVRFWVGENRLPESYLRKGEQRPSRAIELARPANLAGKPLVRVQIDEVEFR
>NZ_CP050994.1|WP_168235658.1|2714147_2714744_-|HAD-family-phosphatase
MAIIFDLGRVVVSWDPVGIVRSVRGPDGAEALAELLFNHPDWLEVDRGTLSLHAMARQAEERTGLPAAENLAILQAVPASLLPDPAMVALIEALHSAGHRLYALSNMGHASIDWLEQQEFWRFFSGKVVSARVRMLKPEPDIYRYLLVSFDLKAGECFFIDDSPANVAAARALGLQGTVFTDAPACRRQLVEQGYLPA
>NZ_CP050994.1|WP_111909878.1|2715069_2716242_+|prephenate-dehydratase
MATLDEIRQDITQLDQELLALLAKRKTLSIEVARAKQANPRPIRDTQREQDLLVALIQKGRALGLDAQYITRIYHTIIEDSVLSQQAYLQSLLNPQQQEPMTSVAYLGPRGSYSSLAARKYLARYKDQVIEVNCQNFREVLDTVESGRAAFGVLPIENTSSGSINEVYDVMQHTTLSIVGELTYPIEHCILTAVPTELGRIKTFYAHPQVFQQCSHYLSKLEGARHEICDSSSSAMMKVKELGSPDAAAIGSAAGGELYGLDVLAEQLANQKENYSRFIVVARKPIDVAPQIPAKTTLIMSTSQKPGSLVEALLVLRSHEINMTKLESRPVQGNPWEEMFYLDVSANLQTPAMQAALLELTKITRYVKVLGCYPSEDVKPTAVPPVLMGS
>NZ_CP050994.1|WP_168235659.1|2716579_2717005_-|hypothetical-protein
MRIVFGLMMALLLTACSGNRVVNYDVAEKPDDFPVLKAVGYAVIDIQPGPSQAEKMLQAIRASKMDAYRELAEQLNGQQVRGQSSYKDLTQTSNSLDVSVAGMVRGARVVATYPRGNTYATELELDTRNLYHLNQLMAGQF
>NZ_CP050994.1|WP_106886012.1|2717018_2717639_-|hypothetical-protein
MNRIITALAVALALAGCGSADPINRDQGDPRQAAKGMELNWLVARMTDQLMERKSLTTLSEPIAVASFVDLDTLKDTNWMGLQIEESFIYELNRRGEVVVDFKTTGSIQVTPSGDFVMSRNYRDLSARLPISRILTGTFSRNQQGILVNARIIDLRTKMVETTAQSLIPQQYLSGASNSFGRASVNRGYLMRGGQSASGHLVNLTP
>NZ_CP050994.1|WP_168235660.1|2717924_2719079_+|hypothetical-protein
MKVVLLSTLLLASLSARAELIEAQGSAAILGGDEVYAREQATRDALRQALLASGASVSSIQRLENGSLRSEQIQIRSGGDIRQYRLKREEVRNGRMYITLVADIQAERQICLTQHYAKDLTLVRLRMRYPDQASTGALDDMPADLSRRLFETLAAAPQGVVARQWLDENLRIDPLHLQQGDRSALEEIKALSLRTDSQYLVLGSIDDLSLEPQGNQLTSWYKDPIRNFRMQLYLFDGINGSLLGRKEYQGRANWTFSRRELVGSNSGQFWQSSYGQEVSYQLKEAAQDIIAELACAPVTARIVAQHERGPHISLGRRNGVKLGDQFRVQHSADFIDPYGKSRVMRNPADGLFEVVQVFEDGAIISSQNKYSPFNVQIGDLAVLE
>NZ_CP050994.1|WP_168235661.1|2719406_2720624_-|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit
MWSDRFLQDDDARTQARIRKLQNSHRGRQGWLLMAALVTVATFAVWASWFRIDEVARATGEVIASSRVQIIQSVDGGVLEQLLVKEGDRVAPGQLLARLEQTRVGASVGEVEARLFALEARATRLRAEVIGEQRLTFSPDLLARSPETARVEEALFKQRQTGLSEELRTMRVAVSLAQKELRLVEQLYADGDASGSELLRVQRGLNEAEARLVNRRNQFLEEARLELAKAEDDIAQGRQTLTLRKQEQQDSMFTAMVPGIVKNIRVTTVGGVLRPGEELMQIIPVDDDLMIEAKVSTADIARVVPGLEATVRFDTFDYTIFGGVKGEVAYVSADSLKEETSRGMDIYYRVRIKPASYPVTSTTGRVIDVLPGMTAQVDIRTGDRTVMDYLLKPLRKTLGESFGER
>NZ_CP050994.1|WP_168236566.1|2720613_2722746_-|ATP-binding-cassette-domain-containing-protein
MAPALVKQLLVSLQIPCDSNALQQACAQTAHSSTSPGPAQWLRQVLIQAGLKNLTPVQLPWRRLDQRRLPALVWTGDEWWLVERDAAGRLTLINAAGERRGADDTELQDTLVVWLRSPTRRSAEADSVLSGNLATRLVWRELFRERGWLWKVMVATVLVNLLAVGTSIFAMQVYDRVVPTLAYATLTTLVTGMMLIILLDWLLKTTRARILDSLSCAVDKRVSQQVFEHLLHLRLDQQPRSLGTLAAQVGGLDAVRQFFSSGVVFALVDLPFAILFLAFIAIIGGAVGWVYALLLPVALLLGYVTQWRLRALLAQQMLRSNERQGLLVDTIRGAETIRANNAGWRFAQEWQNVTASIDGYSIQQRAVSSFSSVSTGSLSTLAYVAAVVVGVWQIEAGLLTMGGLIACSILGGRVIAPIAQSVQYLAQWQQVRQALQMVHQVLSLARDRRIDQQLLLPDMLPNEVALERVRFAYPESPVCQLDIDRLQFKSGERVLLVGPIGCGKSTLLKMLAGLYGPSEGRVRLGDADLWEIDPQLVASQVGYLPQAVQLFKGTLRSNLALTGVTSDSRLLQITRELGIDGIAASSPQGMDLAISEGGEGLSGGQRQLVALARVLINQPRIWLLDEPTSSLDSESEQRVWAALQEAVQPEDILIVATHRPMAAARLATRVIVMLQGQVVKDGAPDRVLTQMLARPVASSQIGKGGRLDVV
>NZ_CP050994.1|WP_168235662.1|2722774_2724076_-|TolC-family-protein
MVTTLPRLGRQGLLVLSLAALALPVSAQQADGLQAALQAALSLHPAVSGKQAQIEAREYSADAARSQRYPSLTAQVQQYSESSRDATTGEDLSTPVTLRARQPLWAFGRIDNSIAFADADTDVERVDLLRVRRQLLEQTAVAYASVLGSRQRLQVVEASLAAHQSLFEQISRREQGQLASAADVRLAATRLAQAKARVERYAGELEIARSDLLALTQAPLPALQPVASDLLQVSEGEALHQAALNGSAEVRFKKQEIERARASVDQVRTASMPTLYLQAEQDYDQPSYRDETRVSLVLEGTLEGMGFATRGRTDAAVAQQSAAEEDLAYAVSELERSVRRLQRSRELQTGLIRVQSESLAELGAVLGSYQRQYVAGTKSWLDVLNIQREFSEQQLQLVQSKSDWEIYSLQLAALTGGLDPLVTLNGEEFQPHG

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Crispr_ID: NZ_CP050994_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_14

2733939-2734063

Orphan

Consensus_repeat	Method
CTCTGGCTCACCCCTTGCTCTGCTCCCTCACGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_14

>merge|NZ_CP050994|14|2733939-2734063|CRISPRCasFinder
CTCTGGCTCACCCCTTGCTCTGCTCCCTCACGCCCTGCTCTGCTGATACTGGCAAATCACCGGCCTGACATTGAACAGGACATTGGGGAAGCTCTGGCTCGCCCCTTGCTCTGCTCCCTCACGCC

>NZ_CP050994|14|14|2733939-2734063|CRISPRCasFinder
CTCTGGCTCACCCCTTGCTCTGCTCCCTCACGCC	CTGCTCTGCTGATACTGGCAAATCACCGGCCTGACATTGAACAGGACATTGGGGAAG
CTCTGGCTCGCCCCTTGCTCTGCTCCCTCACGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_168235668.1\|2738480_2739389_+\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224995
NZ_CP050994.1\|WP_168235665.1\|2731901_2732357_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_168235661.1\|2719406_2720624_-\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|130902
NZ_CP050994.1\|WP_168235663.1\|2724069_2726706_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|379204
NZ_CP050994.1\|WP_163156899.1\|2743024_2744530_+\|GntP-family-permease	unknown	unknown	gnl\|CDD\|308194
NZ_CP050994.1\|WP_106886006.1\|2737437_2738226_-\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP050994.1\|WP_168235664.1\|2726777_2731466_-\|cadherin-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|206637
NZ_CP050994.1\|WP_106886012.1\|2717018_2717639_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379995
NZ_CP050994.1\|WP_168235672.1\|2742077_2743028_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187549
NZ_CP050994.1\|WP_168235670.1\|2740631_2741264_+\|aldolase	unknown	unknown	gnl\|CDD\|181241
NZ_CP050994.1\|WP_168235671.1\|2741260_2742034_+\|hydroxypyruvate-isomerase-family-protein	unknown	unknown	gnl\|CDD\|226149
NZ_CP050994.1\|WP_168235667.1\|2736158_2737220_+\|PQQ-dependent-sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|369642
NZ_CP050994.1\|WP_163148764.1\|2737262_2737418_+\|entericidin-A/B-family-lipoprotein	unknown	unknown	gnl\|CDD\|227797
NZ_CP050994.1\|WP_168235659.1\|2716579_2717005_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225563
NZ_CP050994.1\|WP_168236566.1\|2720613_2722746_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|274550
NZ_CP050994.1\|WP_168235660.1\|2717924_2719079_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379855
NZ_CP050994.1\|WP_106887873.1\|2733094_2733919_+\|polyphosphate-kinase-2	unknown	unknown	gnl\|CDD\|213852
NZ_CP050994.1\|WP_168235666.1\|2734238_2735879_-\|SulP-family-inorganic-anion-transporter	unknown	unknown	gnl\|CDD\|223732
NZ_CP050994.1\|WP_168235669.1\|2739385_2740639_+\|four-carbon-acid-sugar-kinase-family-protein	unknown	unknown	gnl\|CDD\|225930
NZ_CP050994.1\|WP_168235662.1\|2722774_2724076_-\|TolC-family-protein	unknown	unknown	gnl\|CDD\|273829

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_168235668.1\|2738480_2739389_+\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|224995	COG2084, MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism].	3.46534e-92
NZ_CP050994.1\|WP_163148764.1\|2737262_2737418_+\|entericidin-A/B-family-lipoprotein	gnl\|CDD\|227797	COG5510, COG5510, Predicted small secreted protein [Function unknown].	2.02294e-05
NZ_CP050994.1\|WP_168235661.1\|2719406_2720624_-\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|130902	TIGR01843, Hemolysin_secretion_protein_D_plasmid, type I secretion membrane fusion protein, HlyD family. Type I secretion is an ABC transport process that exports proteins, without cleavage of any signal sequence, from the cytosol to extracellular medium across both inner and outer membranes. The secretion signal is found in the C-terminus of the transported protein. This model represents the adaptor protein between the ATP-binding cassette (ABC) protein of the inner membrane and the outer membrane protein, and is called the membrane fusion protein. This model selects a subfamily closely related to HlyD; it is defined narrowly and excludes, for example, colicin V secretion protein CvaA and multidrug efflux proteins. [Protein fate, Protein and peptide secretion and trafficking].	3.09311e-88
NZ_CP050994.1\|WP_168235663.1\|2724069_2726706_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|379204	pfam13469, Sulfotransfer_3, Sulfotransferase family.	1.02266e-43
NZ_CP050994.1\|WP_163156899.1\|2743024_2744530_+\|GntP-family-permease	gnl\|CDD\|308194	pfam02447, GntP_permease, GntP family permease. This is a family of integral membrane permeases that are involved in gluconate uptake. E. coli contains several members of this family including GntU, a low affinity transporter, and GntT, a high affinity transporter.	3.09241e-138
NZ_CP050994.1\|WP_106886006.1\|2737437_2738226_-\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	1.43115e-91
NZ_CP050994.1\|WP_168235664.1\|2726777_2731466_-\|cadherin-repeat-domain-containing-protein	gnl\|CDD\|206637	cd11304, Cadherin_repeat, Cadherin tandem repeat domain. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.	2.18028e-15
NZ_CP050994.1\|WP_106886012.1\|2717018_2717639_-\|hypothetical-protein	gnl\|CDD\|379995	pfam17680, FlgO, FlgO protein. This entry represents the FlgO protein. Mutation of this protein in Vibrio cholerae has been shown to reduce motility. FlgO is an outer membrane protein that localizes throughout the membrane and not at the flagellar pole. Although FlgO and FlgP do not specifically localize to the flagellum, they are required for flagellar stability. Proteins in this family mostly contain an N-terminal lipoprotein attachment motif.	1.03518e-46
NZ_CP050994.1\|WP_168235672.1\|2742077_2743028_+\|SDR-family-oxidoreductase	gnl\|CDD\|187549	cd05238, Gne_like_SDR_e, Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs. Nucleoside-diphosphate-sugar 4-epimerase has the characteristic active site tetrad and NAD-binding motif of the extended SDR, and is related to more specifically defined epimerases such as UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), which catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. This subgroup includes Escherichia coli 055:H7 Gne, a UDP-GlcNAc 4-epimerase, essential for O55 antigen synthesis. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	7.32625e-135
NZ_CP050994.1\|WP_168235670.1\|2740631_2741264_+\|aldolase	gnl\|CDD\|181241	PRK08130, PRK08130, putative aldolase; Validated.	3.5798e-134
NZ_CP050994.1\|WP_168235671.1\|2741260_2742034_+\|hydroxypyruvate-isomerase-family-protein	gnl\|CDD\|226149	COG3622, Hfi, Hydroxypyruvate isomerase [Carbohydrate transport and metabolism].	3.69366e-134
NZ_CP050994.1\|WP_168235667.1\|2736158_2737220_+\|PQQ-dependent-sugar-dehydrogenase	gnl\|CDD\|369642	pfam07995, GSDH, Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.	8.02522e-171
NZ_CP050994.1\|WP_168235659.1\|2716579_2717005_-\|hypothetical-protein	gnl\|CDD\|225563	COG3018, COG3018, Uncharacterized protein conserved in bacteria [Function unknown].	1.97678e-13
NZ_CP050994.1\|WP_168236566.1\|2720613_2722746_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|274550	TIGR03375, type_I_sec_LssB, type I secretion system ATPase, LssB family. Type I protein secretion is a system in some Gram-negative bacteria to export proteins (often proteases) across both inner and outer membranes to the extracellular medium. This is one of three proteins of the type I secretion apparatus. Targeted proteins are not cleaved at the N-terminus, but rather carry signals located toward the extreme C-terminus to direct type I secretion. This model is related to models TIGR01842 and TIGR01846, and to bacteriocin ABC transporters that cleave their substrates during export. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	0
NZ_CP050994.1\|WP_168235660.1\|2717924_2719079_+\|hypothetical-protein	gnl\|CDD\|379855	pfam16539, FlgT_M, Flagellar assembly protein T, middle domain. FlgT_M is the middle region of a family of flagellar proteins that make up part of the basal body of the flagellum. The flagellum is a large macromolecular assembly composed of three major parts: the basal body, the hook, and the filament. The basal body has two unique ring structures, the T ring and the H ring. FlgT is required to form and stabilize both ring structures. FlgT-N and FlgT-M are thought to be involved in the H-ring and the T-ring formation, respectively. and FlgT-M is also required for the stable association of FlgT with the basal body.	3.24672e-39
NZ_CP050994.1\|WP_106887873.1\|2733094_2733919_+\|polyphosphate-kinase-2	gnl\|CDD\|213852	TIGR03707, PPK2_P_aer, polyphosphate kinase 2, PA0141 family. Members of this protein family are designated polyphosphate kinase 2 (PPK2) after the characterized protein in Pseudomonas aeruginosa. This family comprises one of three well-separated clades in the larger family described by pfam03976. PA0141 from this family has been shown capable of operating in reverse, with GDP preferred (over ADP) as a substrate, producing GTP (or ATP) by transfer of a phosphate residue from polyphosphate. Most species with a member of this family also encode a polyphosphate kinase 1 (PPK1). [Central intermediary metabolism, Phosphorus compounds].	3.66266e-137
NZ_CP050994.1\|WP_168235666.1\|2734238_2735879_-\|SulP-family-inorganic-anion-transporter	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	2.83694e-111
NZ_CP050994.1\|WP_168235669.1\|2739385_2740639_+\|four-carbon-acid-sugar-kinase-family-protein	gnl\|CDD\|225930	COG3395, COG3395, Uncharacterized protein conserved in bacteria [Function unknown].	2.30028e-152
NZ_CP050994.1\|WP_168235662.1\|2722774_2724076_-\|TolC-family-protein	gnl\|CDD\|273829	TIGR01844, Proteases_secretion_protein_PrtF, type I secretion outer membrane protein, TolC family. Members of this model are outer membrane proteins from the TolC subfamily within the RND (Resistance-Nodulation-cell Division) efflux systems. These proteins, unlike the NodT subfamily, appear not to be lipoproteins. All are believed to participate in type I protein secretion, an ABC transporter system for protein secretion without cleavage of a signal sequence, although they may, like TolC, participate also in the efflux of smaller molecules as well. This family includes the well-documented examples TolC (E. coli), PrtF (Erwinia), and AprF (Pseudomonas aeruginosa). [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Porins].	2.85437e-27

>NZ_CP050994.1|WP_106887873.1|2733094_2733919_+|polyphosphate-kinase-2
MASKKKSKAEQPVPVAEPKPLGNKAYEKELRRLHVELVKLQQWVVHKGLKVCIVFEGRDGAGKGGTIKAITERVSPRVFRVIALPAPTEREKSQLYFQRYIPHLPAAGEIIIFDRSWYNRAGVERVMGFCSQEASDKFLAGAPMVEQAMVDSGIILLKYWLEVTPEEQERRLRDRIDDGRKIWKLSPMDIKSFDRWDDYTRARDAMFTATDTAWAPWFLARSEDKKRVRLNIISHLLSHIPYEELPAEPVKLPKRKIGKVKASEHPFRVIPELF
>NZ_CP050994.1|WP_168235665.1|2731901_2732357_+|hypothetical-protein
MNLVISQGTEDVKINGDCGIRLRHHLHREQLSVKVFASLSRFIQIISTGASVNDPRNDHAKVISNLNRKCAIWIDPSRSQQGDAVSLVNLDTQVITRHNRTAHYGPGNLVDYAGIGATIAIATSAAAGRQSNPTQAQSPQPNVHGGEEVAI
>NZ_CP050994.1|WP_168235664.1|2726777_2731466_-|cadherin-repeat-domain-containing-protein
MQSIYTAAASDAGIVTYSLKVAGDHDAFTINAATGAVTLIGNPDHETKPSYSFTVVATDAAGNASEQAVTLNINDLDEVAPTITSGATASAIDENSGAGQLVYTVASTDSADVSTGSTSYSLKAGADAALLSIDAATGAVTLIGNPDHETKPSYSFTVVATDAAGNASEQAVTLNINDLDDLAPTITSGATASAIDENSGAGQLVYTVTSTDSGDVATGNTSYSLKAGADAALFSIDAATGAVTLTGNPDHESKASYSFTVVATDAAGNASEQAVTLNINDLDEVAPTITSAATASAIDENSGAGQLVYTVTSTDSADVSTGSTSYSLKAGADAALLSIDAATGAVTLTGNPDHESKPSYSFTLVATDAAGNASEQVVTLNITDLDEVAPTITSGTTASAIDENIGAGQLVYTVTSTDNGDVSTGSTSYSLKAGADAALFSIDAATGAVTLTGNPDHESKASYSFTVVATDAAGNASEQAVTLNINDLGDLAPTITSGATASAIDENSGAGQLVYTVTSTDSADVSTGSTSYSLKAGADAALLSIDAATGAVTLIGNPDHESKASYSFTVVATDAAGNASEQVVTLDVNDLDEVAPTITSGVTASAIDENSGAGQVVYTVTSTDSGDVATGNTSYSLKAGADAALFSIDAATGAVTLTGNPDHESKPSYSFTLVAMDAAGNASEQLVTLNVNDLDEVAPTITSAATASAIDENSGAGQLVYTVTSTDGGDVSSGNTSYSLKAGADAALFSIDAATGAVTLIGNPDHESKAIYSFTVVATDAAGNASEQTVTLNINDLDEVAPTITSAATASAIDENSGAGQVVYTVTSTDNGDVSTGSTSYSLKAGADAALFSIDAATGAVTLIGNPDHESKASYSFTVVATDAAGNASEQTVTLDINNLDDVAPTITSGTTASAINENSGAGQVVYTVTSTDSADVSTGSTSYSLKAGADAALFSIDAATGAVTLTANPDYETKPNYSFTVVATDAAGNASEQLVTLAINDLIDEVAPAVGSIAISGASGAQNSRLNAGDVVNITVTMDEATLVDTTGGTPRVALNIGGSTVYADYVSGSGTASLVFQYTVLAGQTDVNGISLDANALQANGGTLRDAAGNAATLGHGAVADNTSYLVDTTAPGVSSVAITSASGVQSSTLNAGDLVSVTVAMNEATVVNTAGGTPRLALNIGGSTVYADYVSGSGTAALVFQYTVLPGQTDANGISIAAGALAANGGTLRDSAGNDANLNHSLVADNASFLVDTTAPVVSGVSSSTAAGTYGVGEVISIQVSFSEAVTVTGMPQLTLETGTTDRTIDYVSGSGSNTLTFNYTVQAGDTSADLDYLSSGALGLNGGTIRDAAGNLAALTLPASGTAGSLGANEAIVIDTSGPVVNNSIVVFDMVQGVSSDHSSRTFDANTSYTIYIKVHSNTSMLSTAGTGPGTWGTWSGANNLGGDDKIVLVGNGSLPEGYSGYPATVHYNLLINGPGGPGDLVHDGIAWLGTSPVAELRRYGDFVRQYNLNHNTVDLWNGSWAVNANPNAEHIHNSGLNLGQVYMAAMPAGILTSQGLV
>NZ_CP050994.1|WP_168235663.1|2724069_2726706_-|tetratricopeptide-repeat-protein
MSSTPLLRRLALQQQFELLQEACGVPQSPAEQVLLALACAQLGESDAARHALAGLDLAVLDVDGRVDLAAVQLLLGELDMAQELLEIALHDAPDHALLLARLATCQLRRQQTAVARQLYERSLALAPNTLIYQQLLRLYLQEGAIEEGERLLTQAEAFWVGEREQWPEPQAIWHGQQLRGLRLELWLAAEQYAAADAWLDEQQSELEEEPWCDLLGSYAQRLAERGRHAQAEDALRRGLRHYPQQQRLLQQLAQLATLQGRTPQAMALLRRALWLASQGQEPTLALRLKLASIATQSYSTLAREVAQQAIEEAQALQPSKDVGPAQIAHWLAQAQVALAGVEAQEQQYAEAETRYREVLATYPQLLIALQGLGQLYMQLGRINDAIALFEQVKALDPVRGHSALINARRFPDDDTTLQRLEALARVPSLEGPVQPGLLLQLAAAWEKRKDYAKAFALADEANSASRALLGYDPAAHRQACARIRHAFSRSLYEHRRGIGNDSTLPVFVLGMPRSGTTLVEQILAGHSQIHGAGELGLIPGVIAGLERWERHVGSGRHYPDCVDDLDAKVIAGITDNMLKELQEYAPEARHVVDKLPHNFENIGLIKLLFPHARIISVRRDPRDIAISNYFTDYAAKHGGMGFAYDLTWIGEQLADHNLLMHHWNQLFPGEILEVCYEDVLDDPEREARRMLDYIGVAWEPQVLNFSELQRPVKTASVWQVRQPLYKSSMAKWVRYEAHLAPLLRGTNAPIQWQSITDMAALPVPGLLETGVALYREGKLDEAEYHFKQLLHHLPDHAAATFMLGLVYVRKGYLDEGIALMRKAHELCPWQSQWRDDLARAYGLSGEPEKAAQLMRKAPPVAQTALPHNEQEIDGEFSW
>NZ_CP050994.1|WP_168235662.1|2722774_2724076_-|TolC-family-protein
MVTTLPRLGRQGLLVLSLAALALPVSAQQADGLQAALQAALSLHPAVSGKQAQIEAREYSADAARSQRYPSLTAQVQQYSESSRDATTGEDLSTPVTLRARQPLWAFGRIDNSIAFADADTDVERVDLLRVRRQLLEQTAVAYASVLGSRQRLQVVEASLAAHQSLFEQISRREQGQLASAADVRLAATRLAQAKARVERYAGELEIARSDLLALTQAPLPALQPVASDLLQVSEGEALHQAALNGSAEVRFKKQEIERARASVDQVRTASMPTLYLQAEQDYDQPSYRDETRVSLVLEGTLEGMGFATRGRTDAAVAQQSAAEEDLAYAVSELERSVRRLQRSRELQTGLIRVQSESLAELGAVLGSYQRQYVAGTKSWLDVLNIQREFSEQQLQLVQSKSDWEIYSLQLAALTGGLDPLVTLNGEEFQPHG
>NZ_CP050994.1|WP_168236566.1|2720613_2722746_-|ATP-binding-cassette-domain-containing-protein
MAPALVKQLLVSLQIPCDSNALQQACAQTAHSSTSPGPAQWLRQVLIQAGLKNLTPVQLPWRRLDQRRLPALVWTGDEWWLVERDAAGRLTLINAAGERRGADDTELQDTLVVWLRSPTRRSAEADSVLSGNLATRLVWRELFRERGWLWKVMVATVLVNLLAVGTSIFAMQVYDRVVPTLAYATLTTLVTGMMLIILLDWLLKTTRARILDSLSCAVDKRVSQQVFEHLLHLRLDQQPRSLGTLAAQVGGLDAVRQFFSSGVVFALVDLPFAILFLAFIAIIGGAVGWVYALLLPVALLLGYVTQWRLRALLAQQMLRSNERQGLLVDTIRGAETIRANNAGWRFAQEWQNVTASIDGYSIQQRAVSSFSSVSTGSLSTLAYVAAVVVGVWQIEAGLLTMGGLIACSILGGRVIAPIAQSVQYLAQWQQVRQALQMVHQVLSLARDRRIDQQLLLPDMLPNEVALERVRFAYPESPVCQLDIDRLQFKSGERVLLVGPIGCGKSTLLKMLAGLYGPSEGRVRLGDADLWEIDPQLVASQVGYLPQAVQLFKGTLRSNLALTGVTSDSRLLQITRELGIDGIAASSPQGMDLAISEGGEGLSGGQRQLVALARVLINQPRIWLLDEPTSSLDSESEQRVWAALQEAVQPEDILIVATHRPMAAARLATRVIVMLQGQVVKDGAPDRVLTQMLARPVASSQIGKGGRLDVV
>NZ_CP050994.1|WP_168235661.1|2719406_2720624_-|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit
MWSDRFLQDDDARTQARIRKLQNSHRGRQGWLLMAALVTVATFAVWASWFRIDEVARATGEVIASSRVQIIQSVDGGVLEQLLVKEGDRVAPGQLLARLEQTRVGASVGEVEARLFALEARATRLRAEVIGEQRLTFSPDLLARSPETARVEEALFKQRQTGLSEELRTMRVAVSLAQKELRLVEQLYADGDASGSELLRVQRGLNEAEARLVNRRNQFLEEARLELAKAEDDIAQGRQTLTLRKQEQQDSMFTAMVPGIVKNIRVTTVGGVLRPGEELMQIIPVDDDLMIEAKVSTADIARVVPGLEATVRFDTFDYTIFGGVKGEVAYVSADSLKEETSRGMDIYYRVRIKPASYPVTSTTGRVIDVLPGMTAQVDIRTGDRTVMDYLLKPLRKTLGESFGER
>NZ_CP050994.1|WP_168235660.1|2717924_2719079_+|hypothetical-protein
MKVVLLSTLLLASLSARAELIEAQGSAAILGGDEVYAREQATRDALRQALLASGASVSSIQRLENGSLRSEQIQIRSGGDIRQYRLKREEVRNGRMYITLVADIQAERQICLTQHYAKDLTLVRLRMRYPDQASTGALDDMPADLSRRLFETLAAAPQGVVARQWLDENLRIDPLHLQQGDRSALEEIKALSLRTDSQYLVLGSIDDLSLEPQGNQLTSWYKDPIRNFRMQLYLFDGINGSLLGRKEYQGRANWTFSRRELVGSNSGQFWQSSYGQEVSYQLKEAAQDIIAELACAPVTARIVAQHERGPHISLGRRNGVKLGDQFRVQHSADFIDPYGKSRVMRNPADGLFEVVQVFEDGAIISSQNKYSPFNVQIGDLAVLE
>NZ_CP050994.1|WP_106886012.1|2717018_2717639_-|hypothetical-protein
MNRIITALAVALALAGCGSADPINRDQGDPRQAAKGMELNWLVARMTDQLMERKSLTTLSEPIAVASFVDLDTLKDTNWMGLQIEESFIYELNRRGEVVVDFKTTGSIQVTPSGDFVMSRNYRDLSARLPISRILTGTFSRNQQGILVNARIIDLRTKMVETTAQSLIPQQYLSGASNSFGRASVNRGYLMRGGQSASGHLVNLTP
>NZ_CP050994.1|WP_168235659.1|2716579_2717005_-|hypothetical-protein
MRIVFGLMMALLLTACSGNRVVNYDVAEKPDDFPVLKAVGYAVIDIQPGPSQAEKMLQAIRASKMDAYRELAEQLNGQQVRGQSSYKDLTQTSNSLDVSVAGMVRGARVVATYPRGNTYATELELDTRNLYHLNQLMAGQF
>NZ_CP050994.1|WP_168235666.1|2734238_2735879_-|SulP-family-inorganic-anion-transporter
MSSPASAPRRSLSDLLAGVTAAAVVLPKAMAYASVAGLPVAVGLYTALVPMLLYALLGSSRVLSVSSTSTLAILTATQLGLVVPDGDPGRLLTVTATLTLLVGAMLMLAAVLRLGFVANFISLPVLVGFKSGIGLVIILDQLPKLFGVHIQKENFFLDLYHLGQALPQTSWLTLVVALVTLVVLVFMEWRFPHSPAPLLGVGIGIALVWGFGLNEAGVAIVGSIPTGLPALTMPDLTLVLQLLPGAAGIALMSFTETIAAGRAFVGKEEPEINPNRELVATGLANLGGAFCGSMPAGGGTSQTAVVRSVGGLSQWASAVTAAMALATMIFLAPLLSWLPSATLAVVVIVYSVGLIQPGEFRKIGQIRMMEFRWAAIACLGVLLFGTLEGIVVAILASLLGLASQTAQPPVYVIGRKPGEDVLRPLAARHPDDETIPGLLILRPEGRLFFINVQHVAARIRELTETHQPEVVVLDMSRVQDVEYSALMMLMEGEQQARARGVTLWLAGLNPGVLENVRRSGLADQLGESRMLFNARAAIRQYQQSRE
>NZ_CP050994.1|WP_168235667.1|2736158_2737220_+|PQQ-dependent-sugar-dehydrogenase
MLRLLVLLLICLVSPLRALTLTPLVEGLNHPWGLALLPEGGYLIGERPGRLLRIDAGGERHVISGLPPIANQGQGGLLDLALDHEGWVYLSYSEPGDGGAGTAVARARLQKDALVDWQLLFRQQPKVAGGAHFGSRLVLTDDGYLFITLGDRYSERARAQTLDNHLGKTVRLHKDGRVPADNPFVKTAGVLPEIWSLGHRNMQGAALRPVSQQFWAHEHGPQGGDEVNLILPGHNYGWPVVTFGEEYGGGKIGVGQSAPGMTPPLWVWVPSIAPSGMTFYQGALFKEWQGDLLVGALRGQALLRLRLAGDKIISEERLLTDLGERIRTIREGADGALYLLTDSGKGRLLKLTP
>NZ_CP050994.1|WP_163148764.1|2737262_2737418_+|entericidin-A/B-family-lipoprotein
MNMNRTLLVLCASLWLLGCNTIHGVGRDIEKAGEVIQGSANLTSESQAGKE
>NZ_CP050994.1|WP_106886006.1|2737437_2738226_-|DeoR/GlpR-transcriptional-regulator
MIPVERQQRILQLLAERGVVSIVELTEWLQVSHMTIRRDIQKLEEQGRVLSVSGGVSLSQRIKSEPSHATKRSLMQGAKLAIARLAADQVAEGSTVYLDAGTTSLELARELALREDLMIVTNDFMVCAYLIEHGRCRLYHTGGQVIRENQSCAGEATAHFLRNLHLDVAFLSASSWDGQGISTPSEQKVPVKRAVVESAASRILICDSSKYGKVGTFNVVGWDAIDQVITDEQLPQSAREALAQHGVRVTMAPLASLASGVE
>NZ_CP050994.1|WP_168235668.1|2738480_2739389_+|NAD(P)-dependent-oxidoreductase
MSTSYHVAVIGLGAMGMGAARSCLRAGLTTYGIDLSEQARSQLQQAGAAAVMADARPLAETLDAVLLLVVNATQVRRILLGEEGLARHLKPGTAIMVSSTIAAEEASALAAELAQLGLQMLDAPVSGGAIKADAGEMTVMAAGSDAAFDKLAPVLDAVAGKLYRVGSEPGQGSTVKIIHQLLAGVHIAVAAEAMALASRAGVPLDLMYDVVTHAAGNSWMFENRMPRVLTGDYQARSAVDIFVKDLTLVADTAKALRFPLPLASTALNMFLSASNAGHGQEDDSAVIKTFSGITLPGQEERP
>NZ_CP050994.1|WP_168235669.1|2739385_2740639_+|four-carbon-acid-sugar-kinase-family-protein
MKLGVIADDFTGATDIAGFLVENGLSTLQLSGVPEHDGDLPQVDAVVISLKSRSCPAGEAVRDSLAALAWFQARGCPRIYQKYCSTFDSTAAGNIGPVTDALLAALGQDFTLICPALPVNGRTVYQGNLFVGALPLAESGMRHHPITPMQDSNLLRLMERQAQGRAGLVPFATIDKGAAAIAGAFEQLAEDGVRYAVVDTLTEQHLLDIATAALHLPLVTGGSGLAIGLARQLGSGDLQGAREAGWPRGSRAVVLSGSCSEMTNRQVARYRQHAPALALDVARCLEDADYPAELAQWVLAQPLTPAPLVYATTSPGELARIQESHGQQAASDAVEHCFARLAQLLQGAGVDRFIIAGGETSSRVTQALGVKAFHIGPQIAPGVPWVRAIDAPLSLALKSGNFGDEDFFDKAQEYFHD
>NZ_CP050994.1|WP_168235670.1|2740631_2741264_+|aldolase
MTEQALRDTMVMLGASLFQRGYATGGAGNLSALLPDGTLIATPTGSCLGRLSADRLSHVNLQGEHLGGDRPSKEVAFHLAIYHNNPNCRAVVHLHCTHLTALSCLEGLDPANVIRPFTPYYVMRVGQLPLIPYYKPGDARIAEELGRRAPEGNAFLLANHGPVVTGKDLVDAVNNMEELEETARLALMLHGQSIRYLSEHEIDELRRMKP
>NZ_CP050994.1|WP_168235671.1|2741260_2742034_+|hydroxypyruvate-isomerase-family-protein
MSKFAANLTMLFTELPFLERFAAAREAGFAAVEFLFPYEWQAAELGRRLREHGLSQALFNMPPGNWGAGERGMAAIPGREAEFRAHLPCVRDYALALGCTKVHAMSGIVDPAHSLAAHRQTLVDNIRFAADFLAADGIRVLLEPLNDRDVPGYFLAHQLDALALVQEIDRPNVGVQLDLYHAQIMDGDLTRLIGKLGQAIGHVQIASVPDRHEPDEGELAYPHLFKVLAQTGYHDWIGCEYNPRAGTREGPGWLTQQ
>NZ_CP050994.1|WP_168235672.1|2742077_2743028_+|SDR-family-oxidoreductase
MQIIITGGGGFLGQKLARALLQGPQPFTELLLVDIQQPQAPMADPRVRCLQADLTEAGVAESLITERTAVVYHLAAIVSSHAEQDFDLGWKVNLDTTRTLLEACRHTRPGIRFIFTSSLAVYGGSLPALVDDGTALTPTSSYGAQKAMGELLVNDYSRKGYVDGLVLRLPTICVRPGKPNRAASSFVSSIIREPLQGENAICPVSPDLRLWLSSPATVVANFLLAARLPTTGDWRSVNLPGISVTVGEMLETLAKAGGQGARDRVQFAADPAVERIVASWPGRIDNQRASALGFVADRTFADIIDSFITHDMQEAS
>NZ_CP050994.1|WP_163156899.1|2743024_2744530_+|GntP-family-permease
MSDIPTPIIGLVIAVFVLVFLVVRTRVHALIAMLAAACIAGITGGMTIDKTLTVITQGFGSTLGSIGIVIGLGVMMGRLLEVSGAAEQIAYSFIKWLGKRREEWALAITGYIVSIPIFVDSAFVILYPVAKALAKSGKRSILTLGVALAGGLVVTHHTVPPTPGPLGVAGLFGVDIGAMLLMGMALAIPCVLGIVFYAQWLDKKYPEFGAKAAQTPDELQSTYEQYIKEKEGKSLPSLTLSLLPILVPIVLIFVKAIFTTLATLEGMGGLMENPLVQGVNFIGTPIIALAISVLLAVYTLVPHMDRHATAARLEEGLQSAGIILLVTGAGGALGAVLRDSGAGQQLAEQIAQLPISPILIPFIVATLVRLIQGSGTVAMVTAASISAPILAQIPGVNMLLAAQAATMGSLFFGYFNDSLFWVVNRMMGISDVKQQMIVWSIPTTIAWAIGGTGVALLNLVFGSGGTWFDPVLPLLVLALIVWYVRGQSLTPAASVVPSRES

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Crispr_ID: NZ_CP050994_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_15

2955018-2955153

Orphan

Consensus_repeat	Method
CTGGCCCTTTCAATCCCTGTTTCTTTGACCTATCCGAAGGTGAACTGTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_15

>merge|NZ_CP050994|15|2955018-2955153|CRISPRCasFinder
CTGGCCCTTTCAATCCCTGTTTCTTTGACCTATCCGAAGGTGAACTGTTGGTGATGTTGCTCGTGAACTATCCCGTGCCATCCACGCTGGCCCTTTCAATCCCTGTTTCTTTGACCTATCCGAAGGTGAACTGTTG

>NZ_CP050994|15|15|2955018-2955153|CRISPRCasFinder
CTGGCCCTTTCAATCCCTGTTTCTTTGACCTATCCGAAGGTGAACTGTTG	GTGATGTTGCTCGTGAACTATCCCGTGCCATCCACG
CTGGCCCTTTCAATCCCTGTTTCTTTGACCTATCCGAAGGTGAACTGTTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_168235774.1\|2949655_2950393_+\|DNA/RNA-nuclease-SfsA	unknown	unknown	gnl\|CDD\|234733
NZ_CP050994.1\|WP_168235773.1\|2949113_2949659_+\|RNA-2',3'-cyclic-phosphodiesterase	unknown	unknown	gnl\|CDD\|274058
NZ_CP050994.1\|WP_163155882.1\|2953654_2954152_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|223872
NZ_CP050994.1\|WP_163137728.1\|2943865_2946187_-\|penicillin-binding-protein-1B	unknown	unknown	gnl\|CDD\|273952
NZ_CP050994.1\|WP_025328199.1\|2957204_2958122_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP050994.1\|WP_168235780.1\|2960268_2961633_-\|UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl--meso-diaminopimelate-ligase	unknown	unknown	gnl\|CDD\|130153
NZ_CP050994.1\|WP_111910555.1\|2962423_2962759_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235188
NZ_CP050994.1\|WP_168235775.1\|2951081_2951984_+\|tRNA-glutamyl-Q(34)-synthetase-GluQRS	unknown	unknown	gnl\|CDD\|274810
NZ_CP050994.1\|WP_168235778.1\|2958966_2959581_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP050994.1\|WP_005329022.1\|2961866_2962397_+\|inorganic-diphosphatase	unknown	unknown	gnl\|CDD\|179262
NZ_CP050994.1\|WP_168235771.1\|2943413_2943824_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319940
NZ_CP050994.1\|WP_163155880.1\|2954170_2954965_+\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	unknown	unknown	gnl\|CDD\|234723
NZ_CP050994.1\|WP_025328200.1\|2958234_2958765_-\|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223707
NZ_CP050994.1\|WP_025328198.1\|2956434_2957208_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|237896
NZ_CP050994.1\|WP_168235777.1\|2956028_2956376_+\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|224278
NZ_CP050994.1\|WP_162520155.1\|2952171_2953644_+\|polynucleotide-adenylyltransferase-PcnB	unknown	unknown	gnl\|CDD\|236939
NZ_CP050994.1\|WP_168235772.1\|2946442_2948890_-\|ATP-dependent-helicase-HrpB	unknown	unknown	gnl\|CDD\|236950
NZ_CP050994.1\|WP_168235779.1\|2959660_2960272_-\|UbiX-family-flavin-prenyltransferase	unknown	unknown	gnl\|CDD\|180312
NZ_CP050994.1\|WP_005329052.1\|2950518_2950968_+\|RNA-polymerase-binding-protein-DksA	unknown	unknown	gnl\|CDD\|182722
NZ_CP050994.1\|WP_111910454.1\|2962897_2963776_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_168235774.1\|2949655_2950393_+\|DNA/RNA-nuclease-SfsA	gnl\|CDD\|234733	PRK00347, PRK00347, DNA/RNA nuclease SfsA.	5.69684e-134
NZ_CP050994.1\|WP_168235773.1\|2949113_2949659_+\|RNA-2',3'-cyclic-phosphodiesterase	gnl\|CDD\|274058	TIGR02258, UPF0097_protein_AF_2157, 2'-5' RNA ligase. This protein family consists of bacterial and archaeal proteins with two tandem copies of Pfam domain pfam02834. Members for which activity has been measured perform a reversible, ATP-independent 2'-5'-ligation of what is presumably a non-phyiological substrate: half-tRNA splice intermediates from an intron-containing yeast tRNA. The physiological substrate(s) in prokaryotes may include small 2'-5'-link-containing oligonucleotides, perhaps with regulatory or biosynthetic roles. [Transcription, RNA processing].	1.58075e-32
NZ_CP050994.1\|WP_163155882.1\|2953654_2954152_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|223872	COG0801, FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism].	1.98792e-67
NZ_CP050994.1\|WP_163137728.1\|2943865_2946187_-\|penicillin-binding-protein-1B	gnl\|CDD\|273952	TIGR02071, Includes:_Penicillin-insensitive_transglycosylase, penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NZ_CP050994.1\|WP_025328199.1\|2957204_2958122_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	6.53719e-102
NZ_CP050994.1\|WP_168235780.1\|2960268_2961633_-\|UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl--meso-diaminopimelate-ligase	gnl\|CDD\|130153	TIGR01081, mpl, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase. Alternate name: murein tripeptide ligase [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NZ_CP050994.1\|WP_111910555.1\|2962423_2962759_-\|hypothetical-protein	gnl\|CDD\|235188	PRK03987, PRK03987, translation initiation factor IF-2 subunit alpha; Validated.	0.00641609
NZ_CP050994.1\|WP_168235775.1\|2951081_2951984_+\|tRNA-glutamyl-Q(34)-synthetase-GluQRS	gnl\|CDD\|274810	TIGR03838, queuosine_YadB, glutamyl-queuosine tRNA(Asp) synthetase. This protein resembles a shortened glutamyl-tRNA ligase, but its purpose is to modify tRNA(Asp) at a queuosine position in the anticodon rather than to charge a tRNA with its cognate amino acid. [Protein synthesis, tRNA and rRNA base modification].	9.16778e-151
NZ_CP050994.1\|WP_168235778.1\|2958966_2959581_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	9.30666e-11
NZ_CP050994.1\|WP_005329022.1\|2961866_2962397_+\|inorganic-diphosphatase	gnl\|CDD\|179262	PRK01250, PRK01250, inorganic diphosphatase.	1.00447e-128
NZ_CP050994.1\|WP_168235771.1\|2943413_2943824_-\|VOC-family-protein	gnl\|CDD\|319940	cd08352, VOC_Bs_YwkD_like, vicinal oxygen chelate (VOC) family protein Bacillus subtilis YwkD and similar proteins. uncharacterized subfamily of vicinal oxygen chelate (VOC) family contains Bacillus subtilis YwkD and similar proteins. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	7.06291e-70
NZ_CP050994.1\|WP_163155880.1\|2954170_2954965_+\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	gnl\|CDD\|234723	PRK00311, panB, 3-methyl-2-oxobutanoate hydroxymethyltransferase; Reviewed.	9.20496e-164
NZ_CP050994.1\|WP_025328200.1\|2958234_2958765_-\|hypoxanthine-phosphoribosyltransferase	gnl\|CDD\|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	1.02418e-92
NZ_CP050994.1\|WP_025328198.1\|2956434_2957208_-\|ABC-transporter-permease	gnl\|CDD\|237896	PRK15066, PRK15066, inner membrane transport permease; Provisional.	1.63403e-172
NZ_CP050994.1\|WP_168235777.1\|2956028_2956376_+\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	1.09975e-14
NZ_CP050994.1\|WP_162520155.1\|2952171_2953644_+\|polynucleotide-adenylyltransferase-PcnB	gnl\|CDD\|236939	PRK11623, pcnB, poly(A) polymerase I; Provisional.	0
NZ_CP050994.1\|WP_168235772.1\|2946442_2948890_-\|ATP-dependent-helicase-HrpB	gnl\|CDD\|236950	PRK11664, PRK11664, ATP-dependent RNA helicase HrpB; Provisional.	0
NZ_CP050994.1\|WP_168235779.1\|2959660_2960272_-\|UbiX-family-flavin-prenyltransferase	gnl\|CDD\|180312	PRK05920, PRK05920, aromatic acid decarboxylase; Validated.	3.02304e-126
NZ_CP050994.1\|WP_005329052.1\|2950518_2950968_+\|RNA-polymerase-binding-protein-DksA	gnl\|CDD\|182722	PRK10778, dksA, RNA polymerase-binding protein DksA.	2.61102e-75

>NZ_CP050994.1|WP_163155880.1|2954170_2954965_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase
MSKITITDLQKMKQDGQKITAITAYDATFAKLFDDEGAQVLLIGDSLGMVLQGGDDTLAVSMDEMVYHTRCVVRGTSKALVVTDMPFMSYATPEQTYQNAARLMAAGARMVKMEGGDWLCESIRHLTRNGVPVCGHLGLTPQSVHVFGGFKVQGRDEFHAQEIYRQALELQAAGIQLLVLECVPVALAERISKALRIPVIGIGAGPATDGQILVMHDAFGITSGYVPKFTKNFLAETGDMRAAIRLYVQQVSEGTFPGPEHCFN
>NZ_CP050994.1|WP_163155882.1|2953654_2954152_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MIEVFVAIGSNLGNPVAQARQAVAALGRLPESELQQTSQLYGSRPMGPADQPDYVNAVVRLHTRLGPLALLDQLQKIEREQGRVRKDERWGPRTLDLDLLLYGEQVIQHERLIVPHYGMKEREFVLLPLAEIAPALVLPCGTPLTELVARCPRNGLEILACATGE
>NZ_CP050994.1|WP_162520155.1|2952171_2953644_+|polynucleotide-adenylyltransferase-PcnB
MKRCTIFSQIANFCRKVLGKEDGEQSMESPIPARVAGQRRTLSRDQHPISRKEISENALKVLYRLNKGGYEAYLVGGGVRDILLGRTPKDFDIATDATPEQIKALFSNCRLIGRRFRLAHIVFGRDVIEVATFRGHHHQVNTSKHVSAQSDEGMLLRDNVYGTIEEDAERRDFTVNALYYSAKDFTLHDFEGGIEDLAERKLELIGDPETRYREDPVRMLRAVRFAAKLEMTISPRTAAPIRELAPLLQDIPAARLFEETLKLFLAGDGLATYKLLREYGLFQPLFPQVAALFTPNGNSPYEQFIELALMDTDTRVREDKRVTPAFLYATLLWGAVEARARVLENESGLPWHDAFMLAINEVLDAQVRIIAVPRRFTTDVRDIWALQQRLTRRQGRHPERAMEHPKFRAAFDFLLLRNRVERGLGELASWWERYVASNPDVRPQLQREATRRPASGERAPAAEPRGDGEKRSSNSRNRRRPRRRKPKAAE
>NZ_CP050994.1|WP_168235775.1|2951081_2951984_+|tRNA-glutamyl-Q(34)-synthetase-GluQRS
MAMTPSSPVRPHIGRFAPSPSGPLHFGSLVAALGSFLQARTLQGRWLVRIEDIDPPREMAGASGLILQTLEAYGLGWDGEVMYQSARHGRYDEIIEGLYRAGDLYWCRCTRREIMAAGGFYNGHCRTLGLTAEGCAARLRQHNPVYHFEDELQGHIAVPAALAEEDFIVRRRDGLYAYNLAVVVDDMDSGITEIVRGADLLEPTVRQIALYQTLGADVPAWVHLPLAVLADGNKLSKQNHAPALALDDVRPALWQALAFLGQCPPPCLRENTVDEIIAWGIAHWQLARVPRQQKIVLGAR
>NZ_CP050994.1|WP_005329052.1|2950518_2950968_+|RNA-polymerase-binding-protein-DksA
MPTGENRKSLGPLAIAGVEPYQVKAGEEYMNDQQKVHFRKILGAWRNQLMQEVDRTVDHMKDEAANFPDPVDRAAQEEEFALELRTRDRERKLIKKIEKTLLLLEEDDFGYCEHCGIEIGIRRLEARPTADLCVDCKTLAEIKEKQMAG
>NZ_CP050994.1|WP_168235774.1|2949655_2950393_+|DNA/RNA-nuclease-SfsA
MIFDPPLQSGLLIARYKRFLTDVQLADGETITIHCANTGAMTGCADPGTRVWYSTSNNPKRKLAHSWEIAQSPAGHFICVNTARANQIARELIEQGALAPLAGYARLRTEVKYGEENSRIDLLLEDDHRPSCYIEVKSVTLLDEREQAGMGYFPDAVTARGAKHLRELMAMKAAGHRAVLLFMVLHSGIARMRPAAHIDPHYSQLVEQAMAAGVEILCYRPHVGVQGMVAQDFIPFESDHLLPEG
>NZ_CP050994.1|WP_168235773.1|2949113_2949659_+|RNA-2',3'-cyclic-phosphodiesterase
MPRLFFALPLHQLAPALIDWRERRPWPGLPVSERNLHLTLAFLGEADEATRDRLIAAAAQQRCPPFSVHLDHIGWFQRARAAWVGPSEWPNELNVLARALRRHGEKLGLGNGEQGYRPHVTLSRKAGEAPEALPAPDLVLQADSFCLYQSVSTPQGVGYEPIACWPLRARIKETNSEELTP
>NZ_CP050994.1|WP_168235772.1|2946442_2948890_-|ATP-dependent-helicase-HrpB
MSQLPIVSVLPELFDAIDSHASVILQAPPGAGKSTLLPLELVRLNRLPGRIIMLEPRRLAARNIAGFLARQLGEKVGERIGLRVRGESRTSAATRLEIVTEGVLTRMLQQDPELTGVSLVIFDEFHERSLHADTALAFAIESQQGLREDLKLLIMSATLEGMALEALLPDAPVIRSEGRGFPIDYHYRPTNRQQWLEPQVGAVVLEALASHTGSALVFLPGQGEIERLAQWLEGRLPDDVRLAPLYGRLDMAAQQAAIEPAPAGSRKLVLTTNVAETSLTIEGVSVVIDSGLERRATFDLRSGVTRLETRQIARASATQRAGRAGRLGPGVCYRLWSSEVQERLAEQSPPDILTQELTGLLLDAAQWGARVESLPLLDMPPAAAVASARRLLVALGAMKAEGEPQLTPAGRTMAAFGTHPRLARMLLRARELEAEGLTGIVADGAFLVALLEEDLRGSERLSVLFHRRLGALRQGAARWFERLGARPATAQGQWLGLLCALAWPDRIGKLRSGSRYQLSGGIGCDLVEGHPCQGQGALIAIEMGQNDRGSRIFIAEPVALDELVRQLPELVSERQWFDWDEREERVRAERQQMLGELVLGQRPLTDLSDEQKGRCLLQGIRRKGLHVLPWDDASEGLLARLRCARDWLPDEGWPAMDEESLLARLEEWLLPALSGMTRLEQLKKLNLSDLLRQSLPWPLPKRLDEALPSHFSAPTGSRVRIRYQPGQAPVIPVRIQEMFGQGTTPCVADGRVPLVVELLSPAQRPLQITADLAAFWAGSYEQVKKEMKGRYPRHYWPDNPLEAMPTKVTKKKMGM
>NZ_CP050994.1|WP_163137728.1|2943865_2946187_-|penicillin-binding-protein-1B
MATQRRKSPPKKAAPKRTIWRKLFWLGFKLSLVVAAFMVVFGIYLDTKVRERFDGEKWQLPVMVYSRPLELYPSQRLSQTQMLRELNMLSYKQVRQPHTPGEYAVNGNRIELVRRPFEFHDGADGARGLRLTFNGARLEGIQSLENQRQLGYAQMDPVLLDRLNTEDREDRLLVRIAEVPDSLLVTLLTTEDRDFYQHGGVSPVAIMRAMVANVLAGRTVQGGSTLTQQLAKNFFLTRERSLWRKAQEAYMAVLIDYRYSKDEILEAYLNEVYLGQNFSQGVYGFGLASYFYFGIPVNELDIDQVALLVGMVKGPSYYDPWRFPERAKARRDLVLKLLMEHGSLTQAEYELASKQPLGIITRGQMSYGRTPAFMGLLKREIQNRFGPDLLKQSGLKIFTSLDPIAQHAAEQAVETGLATIEKQRGKKKLEAAMVVSDWHKGEVVAMVGGRDPRYAGFNRALDARRQIGSLVKPAVYLTGLSNGLTLGTPLKDQPIRIRGQDGQIWTPQNYDRKFRQSVPLMEALASSLNVPTVNLGLQVGLDKVVDTLHKLGVQQEIQPYPSLVLGAVALSPMEVNQMYLPIANQGLTQPLSAIRAVVNSDGSQLYQHDETAKRVTDPQASWLTLFAMTKTVSQGTARALGAKFPGATMAAKTGTTNELRDSWFAGMDNNELVSVWVGRDDNQPAGLTGASGALQLFSGYMSQRGVNSLGLKMPEGVSWASFSRASGARVASDCPGSLQVPAKLAGLGEPMSCASPVSNPVNALDQWFGGFFN
>NZ_CP050994.1|WP_168235771.1|2943413_2943824_-|VOC-family-protein
MTLPLLGGIHHVAIIASDYERSRHFYHQVLGLPILAETLREARHSWKLDLALPDGSQLELFSFPAPPPRPSRPEACGLRHLAFRVTALDPVIAHLEHHGVAVEPVRVDELTGSRFTFFADPDGLPLELYEVDAEPA
>NZ_CP050994.1|WP_168235777.1|2956028_2956376_+|antibiotic-biosynthesis-monooxygenase
MSKKVYCIAQFQPKPGKEQALFQVLQGLEPNTLREDGCLQYRVTRHIPSPFAEGESFPIVFNEIWQDMASFEAHCQRAEIKAFFERYCLAEEGLAAKWNVCVYSDEPADYDAPAL
>NZ_CP050994.1|WP_025328198.1|2956434_2957208_-|ABC-transporter-permease
MNPMTYYIAFKSILAKEVSRFTRIWIQTLVPPAITMSLYFVIFGNLIGSRIGDMGGFSYMEFIVPGLIMMSVITNSYSNVASSFYSAKFQRNVEELLVAPVPNYIIIAGYVGGGVARGLCVGLIVTLVSLFFVPLQVHHLFSVCFTVLLTSILFSLGGLINAVFAKSFDDISIIPTFILTPLTYLGGVFYSISLLPPFWQGVSQVNPIIYMVNAFRYGFLGISDVPLGTAYLIIIGFIVALYGLAWWLISRGTGLRH
>NZ_CP050994.1|WP_025328199.1|2957204_2958122_-|ABC-transporter-ATP-binding-protein
MNALEISGLKKTYQGGVEALKGIDLTVKQGDFFALLGPNGAGKSTTIGVISSLVNKSAGKVKVFGYDIDTDLELAKAQLGLVPQEFNFSQFEKVSQIVTHQAGFYGVPRAEAKVRAEKYLRQLDLWDKRDMAARTLSGGMKRRLMIARALMHEPRLLILDEPTAGVDIEIRRSMWSFLKDLNEQGVTIILTTHYLEEAEMLCRNIGIIDKGRLIENTSMKNLLGKLGRETFLLDLVPGSQVPTLPEFNGRMQDEHTLEVELDKSQSLNSLFEQLSAQGVQVLSMRNKANRLEELFVNLVEEGRKA
>NZ_CP050994.1|WP_025328200.1|2958234_2958765_-|hypoxanthine-phosphoribosyltransferase
MKHNVEVMISEADVAARIAKLGEEITARYQGSDEVVMIGLLRGSCVFLADLCRQCQLPITLDFMTASSYGSGMHSTRDVRILKDLDDDIKGKDVVIVEDIIDTGYTLNKVREILSLREPKSLAICTLLDKPSRREVQVPVDWIGFAIPDEFVVGCGIDYAQKYRNLPFIGKVVPQE
>NZ_CP050994.1|WP_168235778.1|2958966_2959581_+|TetR/AcrR-family-transcriptional-regulator
MEPRAEIRRRTRLSPEARRDQLMECAIEVFSRRGIGRAGHAEIAEQAKVSVATVFNYFNTREDLVDEVLAEIEGFVQQILEQAYNGQGSVRDSIHRHVKLFVDAAYDKPDHASIWLEWSSSVREEVWPRYTRLLDKALERIAPHLQAAMDSGEIRSVLSAQDLARSLTGFGYVMMQMINQPQRPSREEVTDFLFKYVTAPLQVV
>NZ_CP050994.1|WP_168235779.1|2959660_2960272_-|UbiX-family-flavin-prenyltransferase
MNKQITLALTGASGAPYALRLLQCLVQADYKVYLLASSAARVVLKTEQQQEWPGSPKELSAFLCRQYGAREGQIVACGKEEWFSPVASGSAAPRQMVVCPCSMGTVSAIANGASDNLLERAADVVIKERGQLILVPRESPFSAIHLENMLKLARLGVTIMPAAPGFYHEPKSIEDLVDFMVARILDHLGVEHALTERWGYAKS
>NZ_CP050994.1|WP_168235780.1|2960268_2961633_-|UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl--meso-diaminopimelate-ligase
MHIHILGICGTFMGGLAVLAKQLGYRVTGSDANVYPPMSTQLEQQGIELTEGYDPSQLDPAPDLVVIGNAMSRGNPCVEYVLDRNLPYISGPQWLLEHVLQDRWVLAVAGTHGKTTTASMLAWVLEYAKLEPGFLIGGVPGNFPVSARLGSAPFFVIEADEYDSAFFDKRSKFVHYHPRTLVMNNLEFDHADIFPDLAAIQRQFHHLMRTVPSNGRVLFPQADANLGTVREMGCWSEVELVGQDDAKWKAVKLADDGSAFEVWLDGVKQGEVHWECIGEHNVSNGLMAIAAARHAGVMVEYGIAALCQFKSPKRRMELKGEVAGISVYDDFAHHPTAIETTLGGLRAKVGKARILAVLEPRSNTMKLGVHKEELAGCFDGADEVFFFQPANIGWDLGEVTAHMSRPAQVFDDLEALINRLVAESRAGDHILIMSNGGFGGIHDKLIARLRQGTS
>NZ_CP050994.1|WP_005329022.1|2961866_2962397_+|inorganic-diphosphatase
MSLNLVPAGKSLPDDIYVIIEIPQNADPIKYEVDKDSGAIFVDRFMSTPMFYPCNYGYVNATLSLDGDPVDVLVPTPYPLLAGSVIRCRPVGVLKMTDESGEDAKIVAVPHSKLTKQYDHIQDVNDLPELLKAQIQHFFERYKELEAGKWVKVEGWGDKAAAEAEILTSAERYAAK
>NZ_CP050994.1|WP_111910555.1|2962423_2962759_-|hypothetical-protein
MKPVSMCLLILLSLPALAGQVIVNQGMSTADTFALRDQLAREHEWQEWLRFQQAVKWLEVLPVNCDLVGGAGQEYRCGDNYYRPYRQNGRDLYIQGDPPGQSPQRPIKKAP
>NZ_CP050994.1|WP_111910454.1|2962897_2963776_+|hypothetical-protein
MKLAQGLMWSLLFGSAAMANEVNLSWQWQSADGQRKHLQLSTDERVLSASRHEMTLLDASLNYPLETLYSYISPRLYNSINQINQNSPETATKFRNLEQAFTLHDDSLESTQFWQAYEQYQEDAFYEMRVLPCVHPANRQLPCVRPNYSQLFYQFKGDLKPLARQFSAKDLATSVNLLQEWLSAIPTPPEQMDHFAPPLQALQDNKADSDEKALLMASLLAELAPQYNLSIIYPGISIGSVSPAWLAITADSGLEGDTLVIDNQRHVLLTGSPLLAQQMTMAQIPLISEPLY

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Crispr_ID: NZ_CP050994_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_16

3030636-3030775

Orphan

Consensus_repeat	Method
ACCCGGACATGCAGCCAAACCCCAAGCCGACAGTGCTGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_16

>merge|NZ_CP050994|16|3030636-3030775|CRISPRCasFinder
ACCCGGACATGCAGCCAAACCCCAAGCCGACAGTGCTGACGCCGGATCGGGAGTGATCCGGCACAAGCCAGAGGCGGACTGCACAGCCTGCCCCCGGACGACCCGGACATGCAGCCGAACCCCAAGCCGACAGTGCTGAC

>NZ_CP050994|16|16|3030636-3030775|CRISPRCasFinder
ACCCGGACATGCAGCCAAACCCCAAGCCGACAGTGCTGAC	GCCGGATCGGGAGTGATCCGGCACAAGCCAGAGGCGGACTGCACAGCCTGCCCCCGGACG
ACCCGGACATGCAGCCGAACCCCAAGCCGACAGTGCTGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_168235807.1\|3030835_3031246_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_111910478.1\|3020087_3020825_-\|pyridoxine-5'-phosphate-synthase	unknown	unknown	gnl\|CDD\|235380
NZ_CP050994.1\|WP_168235811.1\|3034930_3036706_+\|protein-disulfide-reductase-DsbD	unknown	unknown	gnl\|CDD\|234717
NZ_CP050994.1\|WP_025328262.1\|3026707_3027688_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236525
NZ_CP050994.1\|WP_106885812.1\|3036836_3037262_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_168235812.1\|3037299_3038604_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223737
NZ_CP050994.1\|WP_111910479.1\|3022592_3023264_-\|ribonuclease-III	unknown	unknown	gnl\|CDD\|234633
NZ_CP050994.1\|WP_025328270.1\|3034080_3034422_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_168235809.1\|3033565_3034003_+\|PACE-efflux-transporter	unknown	unknown	gnl\|CDD\|226610
NZ_CP050994.1\|WP_163137646.1\|3031252_3031522_-\|succinate-dehydrogenase-assembly-factor-2	unknown	unknown	gnl\|CDD\|225489
NZ_CP050994.1\|WP_106885821.1\|3027709_3028297_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|182789
NZ_CP050994.1\|WP_168235808.1\|3031635_3032547_+\|tRNA-modifying-protein-YgfZ	unknown	unknown	gnl\|CDD\|236567
NZ_CP050994.1\|WP_139745765.1\|3020968_3021676_-\|DNA-repair-protein-RecO	unknown	unknown	gnl\|CDD\|234622
NZ_CP050994.1\|WP_106885820.1\|3028320_3028902_-\|RNA-polymerase-sigma-factor-RpoE	unknown	unknown	gnl\|CDD\|171347
NZ_CP050994.1\|WP_168235810.1\|3034616_3034934_+\|divalent-cation-tolerance-protein-CutA	unknown	unknown	gnl\|CDD\|376987
NZ_CP050994.1\|WP_163137686.1\|3026155_3026617_-\|SoxR-reducing-system-RseC-family-protein	unknown	unknown	gnl\|CDD\|377263
NZ_CP050994.1\|WP_025328275.1\|3038816_3039896_-\|class-II-fructose-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|236406
NZ_CP050994.1\|WP_042648729.1\|3023264_3024188_-\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|182787
NZ_CP050994.1\|WP_042648728.1\|3024191_3025985_-\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NZ_CP050994.1\|WP_106885825.1\|3021690_3022596_-\|GTPase-Era	unknown	unknown	gnl\|CDD\|234624

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_111910478.1\|3020087_3020825_-\|pyridoxine-5'-phosphate-synthase	gnl\|CDD\|235380	PRK05265, PRK05265, pyridoxine 5'-phosphate synthase; Provisional.	2.7997e-156
NZ_CP050994.1\|WP_168235811.1\|3034930_3036706_+\|protein-disulfide-reductase-DsbD	gnl\|CDD\|234717	PRK00293, dipZ, thiol:disulfide interchange protein precursor; Provisional.	0
NZ_CP050994.1\|WP_025328262.1\|3026707_3027688_-\|hypothetical-protein	gnl\|CDD\|236525	PRK09455, rseB, anti-sigma E factor; Provisional.	1.44496e-89
NZ_CP050994.1\|WP_168235812.1\|3037299_3038604_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	5.90335e-68
NZ_CP050994.1\|WP_111910479.1\|3022592_3023264_-\|ribonuclease-III	gnl\|CDD\|234633	PRK00102, rnc, ribonuclease III; Reviewed.	2.54243e-124
NZ_CP050994.1\|WP_168235809.1\|3033565_3034003_+\|PACE-efflux-transporter	gnl\|CDD\|226610	COG4125, COG4125, Predicted membrane protein [Function unknown].	4.84403e-51
NZ_CP050994.1\|WP_163137646.1\|3031252_3031522_-\|succinate-dehydrogenase-assembly-factor-2	gnl\|CDD\|225489	COG2938, COG2938, Uncharacterized conserved protein [Function unknown].	5.6339e-32
NZ_CP050994.1\|WP_106885821.1\|3027709_3028297_-\|transcriptional-regulator	gnl\|CDD\|182789	PRK10863, PRK10863, anti-sigma-E factor RseA.	8.91506e-52
NZ_CP050994.1\|WP_168235808.1\|3031635_3032547_+\|tRNA-modifying-protein-YgfZ	gnl\|CDD\|236567	PRK09559, PRK09559, putative global regulator; Reviewed.	1.38062e-98
NZ_CP050994.1\|WP_139745765.1\|3020968_3021676_-\|DNA-repair-protein-RecO	gnl\|CDD\|234622	PRK00085, recO, DNA repair protein RecO; Reviewed.	5.64937e-58
NZ_CP050994.1\|WP_106885820.1\|3028320_3028902_-\|RNA-polymerase-sigma-factor-RpoE	gnl\|CDD\|171347	PRK11923, algU, RNA polymerase sigma factor AlgU; Provisional.	1.07564e-115
NZ_CP050994.1\|WP_168235810.1\|3034616_3034934_+\|divalent-cation-tolerance-protein-CutA	gnl\|CDD\|376987	pfam03091, CutA1, CutA1 divalent ion tolerance protein. Several gene loci with a possible involvement in cellular tolerance to copper have been identified. One such locus in eubacteria and archaebacteria, cutA, is thought to be involved in cellular tolerance to a wide variety of divalent cations other than copper. The cutA locus consists of two operons, of one and two genes. The CutA1 protein is a cytoplasmic protein, encoded by the single-gene operon and has been linked to divalent cation tolerance. It has no recognized structural motifs. This family also contains putative proteins from eukaryotes (human and Drosophila).	2.27934e-48
NZ_CP050994.1\|WP_163137686.1\|3026155_3026617_-\|SoxR-reducing-system-RseC-family-protein	gnl\|CDD\|377263	pfam04246, RseC_MucC, Positive regulator of sigma(E), RseC/MucC. This bacterial family of integral membrane proteins represents a positive regulator of the sigma(E) transcription factor, namely RseC/MucC. The sigma(E) transcription factor is up-regulated by cell envelope protein misfolding, and regulates the expression of genes that are collectively termed ECF (devoted to Extra-Cellular Functions). In Pseudomonas aeruginosa, de-repression of sigma(E) is associated with the alginate-overproducing phenotype characteristic of chronic respiratory tract colonisation in cystic fibrosis patients. The mechanism by which RseC/MucC positively regulates the sigma(E) transcription factor is unknown. RseC is also thought to have a role in thiamine biosynthesis in Salmonella typhimurium. In addition, this family also includes an N-terminal part of RnfF, a Rhodobacter capsulatus protein, of unknown function, that is essential for nitrogen fixation. This protein also contains an ApbE domain pfam02424, which is itself involved in thiamine biosynthesis.	2.13915e-35
NZ_CP050994.1\|WP_025328275.1\|3038816_3039896_-\|class-II-fructose-bisphosphate-aldolase	gnl\|CDD\|236406	PRK09197, PRK09197, fructose-bisphosphate aldolase; Provisional.	0
NZ_CP050994.1\|WP_042648729.1\|3023264_3024188_-\|signal-peptidase-I	gnl\|CDD\|182787	PRK10861, PRK10861, signal peptidase I.	3.25109e-151
NZ_CP050994.1\|WP_042648728.1\|3024191_3025985_-\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NZ_CP050994.1\|WP_106885825.1\|3021690_3022596_-\|GTPase-Era	gnl\|CDD\|234624	PRK00089, era, GTPase Era; Reviewed.	0

>NZ_CP050994.1|WP_106885820.1|3028320_3028902_-|RNA-polymerase-sigma-factor-RpoE
MSDQNLLDEQLVERVQRGDKNAFNLLVKKYQHKVVNLVARYVNNPGDVPDVAQEAFIKAYRALPTFRGESAFYTWLYRIAVNTAKNYLTSQGRRPPSSDVEADEAEYYGGGEALQEVATPENLALTDEIKRTVFAAIEALPEDLRTAITLREMEGLSYEEIAEIMDCPVGTVRSRIFRAREAIDKKLQPLIEN
>NZ_CP050994.1|WP_106885821.1|3027709_3028297_-|transcriptional-regulator
MANKEQLSALMDGDLSDMEVLNELGTDPALQDTWARYHLIGDAMRGDLPVNLQLDLSDSIMLALEDEPVILAPKPVQPVAPQVKPAGKVVPLIRRFGQQMGQYAIAASVAAAVIFGVQQYQGNDGMPANPVLNTIPVGGSATPVSVHYPQEGNRATPRQQGLNEQQMQEQRERINAFLRDHQLQQRLLQDKQIQE
>NZ_CP050994.1|WP_025328262.1|3026707_3027688_-|hypothetical-protein
MRQSSLILLASLLLICAKASADDLSAEALLQQMQSAVSQQNFELSMVKARQGRLEPIRFSHGVIDGKEVAHLSYLDGKAVEYLQRQNEYTFFENTHEPYTLKGARFPGVWSSLVKMPLPRVLESYDPVLAGRSRVAGLVAQVVRLVPKEADKYGFVLWVDEQSHLLLRVDMVDKEGNLVEQVLGVDLDRQPAPAPWLVTLARSKLPDALALEDAYPAPQQTLNWHLTWLPGGFKVLSQDRHQLVSTSLPVDYMMLSDGVVDLSVYVSRVDPKQAVRQQLIRQGATSLVSFVNEVGVEITVVGEVPTETAKRIAESVQPLARNEAVQ
>NZ_CP050994.1|WP_163137686.1|3026155_3026617_-|SoxR-reducing-system-RseC-family-protein
MSEELATVVAVEGAYAWVECERRSACSGCHQQSNCGTGTVAKAFPLKSQRLRVALTAEVLVGQQIRLGIPQASILRGAALVYVLPLFCLLLGALLGQLWLAPLLSAGEGVTILSCLLGGTVGFLLVRYFSARLEQGEYGPRMLGVVLNTRHLS
>NZ_CP050994.1|WP_042648728.1|3024191_3025985_-|elongation-factor-4
MKHIRNFSIIAHIDHGKSTLSDRLIQTCGGLSDREMQAQVLDSMDLERERGITIKAQSVTLNYQAQDGNTYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAMEMELEVVPILNKIDLPAAEPERVAEEIEDIVGIDAIDAVRCSAKTGLGVDLVLEEIVARIPSPEGDPDAPLQALIIDSWFDSYLGVVSLVRIKNGSLKKNDKIKVMSTGQVWGVDRIGIFTPKQVDTMGLGCGEVGWVVCGIKDIHGAPVGDTLTQAKNGADKALAGFKKVKPQVYAGLFPISSDDYESFRDALDKLSLNDASLFFEPESSTALGFGFRCGFLGMLHMEIIQERLEREYDLDLITTAPTVVYEIELNNGETIHIDSPAAMPPVNNIKEMREPIAECNILLPQEYMGNVITLCIEKRGVQTNMVYHGKQVALTYEIPMAEVVLDFFDRLKSTSRGYASLDYGFKRFETSEMVRLDIMINGERVDALAIITHKENAQYRGRQVVEKMRELIPRQMFDIAIQASIGNQIIARSTVKALRKDVTAKCYGGDVSRKKKLLNKQKEGKKRMKSLGRVDVPQEAFLAILHVGKD
>NZ_CP050994.1|WP_042648729.1|3023264_3024188_-|signal-peptidase-I
MASTFSLILAIVTLLTGIIWTVDKLVWSKQRAAKIAAARANAGSNIDEKTLAKVAPMPVWIEQTGGVFPVIALVLILRSFIFEPFQIPSGSMMPTLLVGDFILVEKFAYGLRDPVTNTKFLETGSPERGDVVVFKYPLDTRVDYIKRVVGMPGDRVIYRNKELMIRPKCEEQEGKTCPGFKKLDVKFEQRGEFSQMGIPLDRYTEQLGTVSHETLRNPLMPDLVDRYYRQPGTYPDEWVVPEGHYFVMGDNRDNSTDSRFWGFVPEQNLVGKAVAIWISFEFEREEGSSLPSWVPTGVRFNRIGGIK
>NZ_CP050994.1|WP_111910479.1|3022592_3023264_-|ribonuclease-III
MNIKMNRLQSRLGHVFQDQELLTRALTHRSAGSRHNERLEFLGDSILSLVIADDLFHRFPQAAEGDLSRMRATLVREKTLAELGREFDLGDHLILGPGELKSGGFRRESILADTVEAVIGAVYLDTDLERVRTLLLGWYASRLDEIKPGIEQKDPKTRLQEILQGSRKSLPTYTVTNVKGEAHNQEFTVQCDVDGLDGPLVGVGTSRRKAEQAAAQQALEKLS
>NZ_CP050994.1|WP_106885825.1|3021690_3022596_-|GTPase-Era
MTDTDTTYCGFVAIVGRPNVGKSTLLNKLLGQKVSITSKKPQTTRHRILGIDTEDNHQTIYVDTPGLHIEEKRAINRLMNRAATSSLGDVAMVVFMVDGTHWTKDDEMVLGKLRHLPCPVVLAVNKVDNVKEKEDLLPHLEWLGQQMNFAHILPISAEKGTNVEKIREWAKDLLPENNFFFPEDYVTDRSSRFMASEIIREKLMRFTGEELPYSVTVEIERFKVEENGLYHIHGLILVERDGQKKMVIGNKGEKIKTIGTEARLDMERLFQNKVHLELWVKVKSGWADDERALRSLGYGDD
>NZ_CP050994.1|WP_139745765.1|3020968_3021676_-|DNA-repair-protein-RecO
MLNPAFVIHSRPYRETSQLVEVFTQDSGRFTLVARGSRGPRSPLKGLLQPFTLLTMSWRGKGDLKNLAQVECPDHSLRLGGDRLFYGLYLNELVYYLLEAHTPFPEVFDAYARALMALADGETPELPLRRFEFLLLQALGYAVDFEYAADDDSPIQPELLYGFERELGFVACERAPDPRTLFLGAHLLAFAEGRFDTPPLLQAAKRFSRLALQPYLGKRQLKSRELFLKRRSSLG
>NZ_CP050994.1|WP_111910478.1|3020087_3020825_-|pyridoxine-5'-phosphate-synthase
MSEIYLGVNIDHIATLRNARGTQYPDPVQAAFVAEQAGADGITVHLREDRRHITDRDVEILRQTIQTRMNLEMAVTEEMIGIACRIQPQFVCLVPEKRTEVTTEGGLDVAGQLDKITDAVTRLAAVGAQVSLFIDADPIQIDAAAESGAPFIEIHTGRYADATTDAERNAEFKRIAAGASYAAGKGLKVNAGHGLHYHNVKAIAAIPELYELNIGHAIIGRAAFDGLAKAVSDMRLLMQEARQGI
>NZ_CP050994.1|WP_168235807.1|3030835_3031246_-|hypothetical-protein
MRVLMPVIPSRRQRLLLLALFLLLLWPVAALIHGWQWGLFLPCWLLGLWLAWRPVTQGGETLLWDGEWLEWRGRRHRLDDRSRILPGVLWLRLQTEEGAERHLWLFSDALAPEHYRALARAIHLAPSNPPASPHNR
>NZ_CP050994.1|WP_163137646.1|3031252_3031522_-|succinate-dehydrogenase-assembly-factor-2
MLSPIEKSRLKWACRRGMLELDVIFMPFFEHEFDSLSEAQQQTFIRLLACEDPELFRWSMGHGVPSDPDFAAMIPLILERNQARHDRLS
>NZ_CP050994.1|WP_168235808.1|3031635_3032547_+|tRNA-modifying-protein-YgfZ
MSLPTPVLPAEPTLFPLTDLAITRLTGNDRVKYLQGQVTCDVNALQPGQSTLGGHCEPKGKLWSDFRLLCLDESLLLLTKPSVLARQLPELKKFAVFAKVEIGEFQGQVVGLAGQGTDAWIAGQYGLQETGLVEGGMAVRVEADRWLLASESPLALSLPVGDEALWWGLDIKAGIPHLEAVHQGEYIPQMLNLQALDGISFTKGCYMGQEIVARAKYRGANNRALFVLAGQASGPVASGDTLEIQLGDNWRRSGMVLNAWQQDGQLWLTAVLPKDTEADASFRLKQEEGSRLSLQPLPYSLTE
>NZ_CP050994.1|WP_168235809.1|3033565_3034003_+|PACE-efflux-transporter
MRNTRDRLRHAIGFELIGLLIAAPLASWVTGVGLNHMGPLALFFSVVATVWNYVYNIGVDRLLLRLQGHTHKTLWQRVLHTFGFEGGLLIVALPVMSWWLDIGLLEALVLDLGFVLFYLVYAFVYNWSYDKVFPIPGQRAQRVTG
>NZ_CP050994.1|WP_025328270.1|3034080_3034422_-|hypothetical-protein
MTQQNEQQRNRMLSLLREGERRMLVQLAGLLRTSVDEINAELEKEELLSALEQPITVEYLNGVVQHHLFERLHKGDMVAAQRMLNQYQSDLEAMLNQEAAQTEAPADEVKAQA
>NZ_CP050994.1|WP_168235810.1|3034616_3034934_+|divalent-cation-tolerance-protein-CutA
MTDAILVLCTCPDEASADHLCEQLLNQRLAACINQLPGLTSAYRWQGKIERAREIQLIIKSRQQLFAELERCILAHHPYQVPEILAIPASQGHQAYLDWLTQETS
>NZ_CP050994.1|WP_168235811.1|3034930_3036706_+|protein-disulfide-reductase-DsbD
MTLRSLLSLLLLLLSLLAPPAQASSQDLLSSLGIEASAQPKFLKVDEAFVLESEQQGNKLLLTLRLADGYYLYRHSISVKGENLAFEPLALPAGTEHEDDFFGKTRVFYQELQIPLTLTQVGDSASLQISYQGCTEGLCYPPTDKRIPVQPLAATGDAGQTDPADATEAPTGSQQDRLAAALGSQGFWLSIAAFFALGLGLALTPCVFPMYPILTGIIAGAGQHLSTRRAFLLSFVYVQGMAVTYTLLGLVVASAGLKFQAALQHPYVLIGLSVMFVLLALSMFGLYTLQLPSSLQTRLSGLSNRQQGGSVVGVAIMGMISGLVCSPCTTAPLSGALIYVAQSGDLWLGGAALYALSLGMGLPLLLLGTSGGKLLPKAGAWMDVIKQLFGFALLAVPILLLSRLLSDQVATLLWLGWALLLCGYLYHHNQHRPHSVGKSLGGFVLLLAMMSLVVVGKDLLLPEPGVKASTGAEAPRFIRIKTLDDLKTRLEAARGKPVLLDLYADWCVACKEFEHKTFSAPAVRARFADMVLLQADVTANDDADVDLLNGLNVLGLPTLIFFDAAGNEVSGQRVTGFMGPAEFLGQLDKLR
>NZ_CP050994.1|WP_106885812.1|3036836_3037262_+|hypothetical-protein
MKKWFIPLLACWLYGCNSGPGEEAIQSQVTARLQADTDPALFEISDFAILGKEERMEGVYLVKVSYRLHFKQGLDQLQVLHDEDLVYDRVGPFQQEMALMELERKYGEFEAGQALAQESQVWMMKTEQGWRLAEPDPAQQG
>NZ_CP050994.1|WP_168235812.1|3037299_3038604_-|FAD-binding-oxidoreductase
MQTGRHNGHQEHVASYYAATRNDHQQWPELSGELDADVCIIGGGFTGLNTAINLAEAGYKVVLLEANRIGWGASGRNGGQLIRGIGHDTSQFARWIGEQGVRELDLMGLEAVQLVRERVARFNIDCDLTWGYCDLATKPRHLKGFEEDAEHLASLGYRHELKLVPKGEIRSVVGSDRYIGGMIDMGSGHLHPLNLALGEARAAASLGVALFEQSRVAHIEYGDRVEVTTAHGRCRASYLVIGCNAYLNELNPELGGKVLPAGSYILATQVLEKRLRQRLLPQNMAVCDQNVALDYYRLSADGRLLFGGACNYSGRDPHDIKAFMLPKLLRVFPELAGTAIEFQWGGMIGIGANRLPQIGRLKEYPNVFYAQAYSGHGLNATHMAGKLVAEAIRGESRGFDLFSRVPHMTFPGGPALRSPLLALGMLWHRMKDLL
>NZ_CP050994.1|WP_025328275.1|3038816_3039896_-|class-II-fructose-bisphosphate-aldolase
MSKKIFDFVKPGVITGDDVQKVFAIAKENGFALPAVNCVGTDSVNAVLEAAAKVKAPVIVQFSNGGAVFTAGKGLKLEGQQAAIIGAISGAKHVHAVAEAYGVPVILHTDHAAKKLLPWIDGLLEAGEKHFAETGKPLFSSHMLDLSEESLEENIDICCEYLTRMAKMNMTLELELGCTGGEEDGVDNSHMDQSALYTQPEDVAYAYERLSKISPRFTIAASFGNVHGVYKPGNVKLTPSILDASQKFVSEKFGLPAKSLDFVFHGGSGSTLEEIRESISYGVVKMNIDTDTQWATWEGLLNFYKTNEAYLQGQLGNPEGADKPNKKFYDPRVWLRAGQTSMIARLEKAFSDLNAINVL

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Crispr_ID: NZ_CP050994_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_17

3097975-3098193

Orphan

Consensus_repeat	Method
CCGCCTTCCCCAGCATGTTCCGCAACTACGCCGAGTTATTGCCGCTGGC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP050994_17

>merge|NZ_CP050994|17|3097975-3098193|CRISPRCasFinder
CCGCCTTCCCCAGCATGTTCCGCAACTACGCCGAGTTATTGCCGCTGGCCGTGTGAATCGGCATTTTGCGCATCAATGGGGAAATCACTGGCCGCCTTCCCCAGCATGTTCCGCGACTACGCCGAGTTATTGCCGCTGGCTATTTGATACAGATACGGGGACAGGATTCACCGCCCTCCCCGATGTATTCCGCGACTATGCCGAACTGCTGCCGCTGAT

>NZ_CP050994|17|17|3097975-3098193|CRISPRCasFinder
CCGCCTTCCCCAGCATGTTCCGCAACTACGCCGAGTTATTGCCGCTGGC	CGTGTGAATCGGCATTTTGCGCATCAATGGGGAAATCACTGG
CCGCCTTCCCCAGCATGTTCCGCGACTACGCCGAGTTATTGCCGCTGGC	TATTTGATACAGATACGGGGACAGGATTCA
CCGCCCTCCCCGATGTATTCCGCGACTATGCCGAACTGCTGCCGCTGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_168235843.1\|3093980_3095249_-\|HAAAP-family-serine/threonine-permease	unknown	unknown	gnl\|CDD\|273283
NZ_CP050994.1\|WP_168235848.1\|3101470_3102817_-\|6-phospho-beta-glucosidase	unknown	unknown	gnl\|CDD\|133432
NZ_CP050994.1\|WP_168235852.1\|3107968_3108727_-\|GspN-family-type-II-secretion-system-protein-ExeN	unknown	unknown	gnl\|CDD\|376490
NZ_CP050994.1\|WP_162520147.1\|3096515_3097124_-\|ADP-compounds-hydrolase-NudE	unknown	unknown	gnl\|CDD\|183303
NZ_CP050994.1\|WP_168235845.1\|3098302_3099571_-\|tyrosine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235645
NZ_CP050994.1\|WP_168235841.1\|3087678_3088368_+\|LrgB-family-protein	unknown	unknown	gnl\|CDD\|224265
NZ_CP050994.1\|WP_111910522.1\|3090903_3092082_-\|cystathionine-gamma-synthase	unknown	unknown	gnl\|CDD\|131135
NZ_CP050994.1\|WP_042648380.1\|3087284_3087686_+\|CidA/LrgA-family-protein	unknown	unknown	gnl\|CDD\|224298
NZ_CP050994.1\|WP_106885762.1\|3095661_3096474_-\|3'(2'),5'-bisphosphate-nucleotidase-CysQ	unknown	unknown	gnl\|CDD\|130398
NZ_CP050994.1\|WP_163137615.1\|3088435_3090904_-\|bifunctional-aspartate-kinase/homoserine-dehydrogenase-II	unknown	unknown	gnl\|CDD\|236530
NZ_CP050994.1\|WP_168235851.1\|3107049_3107370_-\|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|182499
NZ_CP050994.1\|WP_042041464.1\|3102970_3103798_-\|transcriptional-regulator-ChbR	unknown	unknown	gnl\|CDD\|182362
NZ_CP050994.1\|WP_168235847.1\|3100651_3101422_-\|chitin-disaccharide-deacetylase	unknown	unknown	gnl\|CDD\|235007
NZ_CP050994.1\|WP_168235849.1\|3104240_3105623_-\|glycoside-hydrolase-family-1-protein	unknown	unknown	gnl\|CDD\|225343
NZ_CP050994.1\|WP_168235842.1\|3093568_3093907_+\|tRNA-binding-protein	unknown	unknown	gnl\|CDD\|182232
NZ_CP050994.1\|WP_168235850.1\|3105677_3107039_-\|PTS-N,N'-diacetylchitobiose-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|182363
NZ_CP050994.1\|WP_005327165.1\|3092376_3092700_+\|met-regulon-transcriptional-regulator-MetJ	unknown	unknown	gnl\|CDD\|179982
NZ_CP050994.1\|WP_168235846.1\|3099716_3100598_+\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NZ_CP050994.1\|WP_168235844.1\|3097270_3097939_+\|GMP/IMP-nucleotidase	unknown	unknown	gnl\|CDD\|237882
NZ_CP050994.1\|WP_106885756.1\|3103830_3104184_-\|PTS-N,N'-diacetylchitobiose-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|182472

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_168235843.1\|3093980_3095249_-\|HAAAP-family-serine/threonine-permease	gnl\|CDD\|273283	TIGR00814, membrane_transport_protein_YhjV, serine transporter. The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family- serine/threonine subfamily (TC 2.A.42.2) The HAAAP family includes well characterized aromatic amino acid:H+ symport permeases and hydroxy amino acid permeases. This subfamily is specific for hydroxy amino acid transporters and includes the serine permease, SdaC, of E. coli, and the threonine permease, TdcC, of E. coli.//added GO terms, none avaialbelf or ser/thr specifically [SS 2/6/05] [Transport and binding proteins, Amino acids, peptides and amines].	5.34347e-140
NZ_CP050994.1\|WP_168235848.1\|3101470_3102817_-\|6-phospho-beta-glucosidase	gnl\|CDD\|133432	cd05296, GH4_P_beta_glucosidase, Glycoside Hydrolases Family 4; Phospho-beta-glucosidase. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases such as the phospho-beta-glucosidases. Other organisms (such as archaea and Thermotoga maritima ) lack the PEP-PTS system, but have several enzymes normally associated with the PEP-PTS operon. The 6-phospho-beta-glucosidase from Thermotoga maritima hydrolylzes cellobiose 6-phosphate (6P) into glucose-6P and glucose, in an NAD+ and Mn2+ dependent fashion. The Escherichia coli 6-phospho-beta-glucosidase (also called celF) hydrolyzes a variety of phospho-beta-glucosides including cellobiose-6P, salicin-6P, arbutin-6P, and gentobiose-6P. Phospho-beta-glucosidases are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	0
NZ_CP050994.1\|WP_168235852.1\|3107968_3108727_-\|GspN-family-type-II-secretion-system-protein-ExeN	gnl\|CDD\|376490	pfam01203, T2SSN, Type II secretion system (T2SS), protein N. Members of the T2SN family are involved in the Type II protein secretion system. The precise function of these proteins is unknown.	4.52925e-53
NZ_CP050994.1\|WP_162520147.1\|3096515_3097124_-\|ADP-compounds-hydrolase-NudE	gnl\|CDD\|183303	PRK11762, nudE, adenosine nucleotide hydrolase NudE; Provisional.	1.81613e-120
NZ_CP050994.1\|WP_168235845.1\|3098302_3099571_-\|tyrosine--tRNA-ligase	gnl\|CDD\|235645	PRK05912, PRK05912, tyrosyl-tRNA synthetase; Validated.	0
NZ_CP050994.1\|WP_168235841.1\|3087678_3088368_+\|LrgB-family-protein	gnl\|CDD\|224265	COG1346, LrgB, Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane].	1.07356e-86
NZ_CP050994.1\|WP_111910522.1\|3090903_3092082_-\|cystathionine-gamma-synthase	gnl\|CDD\|131135	TIGR02080, Cystathionine_gamma-synthase, O-succinylhomoserine (thiol)-lyase. This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family].	0
NZ_CP050994.1\|WP_042648380.1\|3087284_3087686_+\|CidA/LrgA-family-protein	gnl\|CDD\|224298	COG1380, COG1380, Putative effector of murein hydrolase LrgA [General function prediction only].	7.48566e-31
NZ_CP050994.1\|WP_106885762.1\|3095661_3096474_-\|3'(2'),5'-bisphosphate-nucleotidase-CysQ	gnl\|CDD\|130398	TIGR01331, 3'2'5'-bisphosphate_nucleotidase_CysQ, 3'(2'),5'-bisphosphate nucleotidase, bacterial. Sulfate is incorporated into 3-phosphoadenylylsulfate, PAPS, for utilization in pathways such as methionine biosynthesis. Transfer of sulfate from PAPS to an acceptor leaves adenosine 3'-5'-bisphosphate, APS. This model describes a form found in bacteria of the enzyme 3'(2'),5'-bisphosphate nucleotidase, which removes the 3'-phosphate from APS to regenerate AMP and help drive the cycle. [Central intermediary metabolism, Sulfur metabolism].	2.62258e-97
NZ_CP050994.1\|WP_163137615.1\|3088435_3090904_-\|bifunctional-aspartate-kinase/homoserine-dehydrogenase-II	gnl\|CDD\|236530	PRK09466, metL, bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional.	0
NZ_CP050994.1\|WP_168235851.1\|3107049_3107370_-\|PTS-sugar-transporter-subunit-IIB	gnl\|CDD\|182499	PRK10499, PRK10499, PTS sugar transporter subunit IIB.	7.20797e-59
NZ_CP050994.1\|WP_042041464.1\|3102970_3103798_-\|transcriptional-regulator-ChbR	gnl\|CDD\|182362	PRK10296, PRK10296, DNA-binding transcriptional regulator ChbR; Provisional.	6.26401e-158
NZ_CP050994.1\|WP_168235847.1\|3100651_3101422_-\|chitin-disaccharide-deacetylase	gnl\|CDD\|235007	PRK02134, PRK02134, chitin disaccharide deacetylase.	1.14379e-120
NZ_CP050994.1\|WP_168235849.1\|3104240_3105623_-\|glycoside-hydrolase-family-1-protein	gnl\|CDD\|225343	COG2723, BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism].	0
NZ_CP050994.1\|WP_168235842.1\|3093568_3093907_+\|tRNA-binding-protein	gnl\|CDD\|182232	PRK10089, PRK10089, chaperone CsaA.	7.46078e-69
NZ_CP050994.1\|WP_168235850.1\|3105677_3107039_-\|PTS-N,N'-diacetylchitobiose-transporter-subunit-IIC	gnl\|CDD\|182363	PRK10297, PRK10297, PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional.	0
NZ_CP050994.1\|WP_005327165.1\|3092376_3092700_+\|met-regulon-transcriptional-regulator-MetJ	gnl\|CDD\|179982	PRK05264, PRK05264, met regulon transcriptional regulator MetJ.	3.84266e-75
NZ_CP050994.1\|WP_168235846.1\|3099716_3100598_+\|LuxR-family-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	1.28971e-15
NZ_CP050994.1\|WP_168235844.1\|3097270_3097939_+\|GMP/IMP-nucleotidase	gnl\|CDD\|237882	PRK14988, PRK14988, GMP/IMP nucleotidase; Provisional.	5.17521e-95
NZ_CP050994.1\|WP_106885756.1\|3103830_3104184_-\|PTS-N,N'-diacetylchitobiose-transporter-subunit-IIA	gnl\|CDD\|182472	PRK10454, PRK10454, PTS N,N'-diacetylchitobiose transporter subunit IIA.	2.22569e-54

>NZ_CP050994.1|WP_168235844.1|3097270_3097939_+|GMP/IMP-nucleotidase
MPTPLPWHQIDTVLLDMDGTLIDLHFDSHLWQQLVPERYAARLGLPLADAKAQIEAHYQAVSGTLDWYCVDYWSRTLGLDIRALKQEILDKIQWRPHVIPFLAALRAAGKQLVLFTNAHPASLSVKDARLGLADHLDLMVSTHELGWSKESQHCWQALAERLAFDPARTLFVDDSERILRAAADYGIGYQLAIQNPDSRQPEQQITAFPAIRDYAELLPLTL
>NZ_CP050994.1|WP_162520147.1|3096515_3097124_-|ADP-compounds-hydrolase-NudE
MSDPHKCKPEHVRVEAMAHDKRKPEIIKAELVAESRLFKVESLHLKFSNGEERVYERMRGGNRGAVMVVPLFDAHTLLLVREYAAGTHSYELGFPKGLIDPGEDAFEAGNRELMEEAGFGARDLIPLKQVSLAPGYFSSRMDILLARDLYPEQRIGDEPEPLEVIPWPLNRIDELLARPDFTESRSISALLLASKWLAEQES
>NZ_CP050994.1|WP_106885762.1|3095661_3096474_-|3'(2'),5'-bisphosphate-nucleotidase-CysQ
MQELLAWIPGVKEIAREAGRILHEIYHGGQFERQLKEDATPVTSADLAADAYLKQALSALTPHVPVLTEEAADVPFSQRANWRQYWLVDPLDGTGEFIAGSGDFATLIALVRDNVPVLGVIYAPEADVLYWAVRGHGAFKEVNGEVHPISAMHHEHDQPDSLVVAISRRQKLENLTRRLNPAINYELIPLGSSSLKSCLVAEGAADCYVRLGPTGEWDTAAAQCIVEAAGGRILSLALQPLSYNETESLENPDFIVMGDPDLAWGKILTH
>NZ_CP050994.1|WP_168235843.1|3093980_3095249_-|HAAAP-family-serine/threonine-permease
MSSSVEVSRELSGSHSTTASTGWRRHDTHWVISLFGTAVGAGILFLPINLGLGGIWPLVIVAVLAGPMTFLAHRGLARFVLSSSRPHADFTEVAEEHFGKMAGRLISALYFLSIFPILLIYGVGLTNTVESFMINQLGMDAPNRVMLSGLLVFAMIAVMMAGEKAMLRAFAFMVYPLAAILAALSCYLIPQWQWPQMTAFEGTSFLNTVWLALPVTVFAFSHAAAISGFANVQRREYGEQAEAKSGLILRNTTVMLVGFVLFFVFSCVLSLSPAQLAEAKAQNVSVLSYLANITDNPVIVTLGPLIAFIAISSSFLGHFLGARESLKSLIAKPTGLSLAKSDWLGIALMFFAIWGAAVINPGILGLMETLSGPVIAMILFIMPVVAIYKVEALARFRQGWVNGFILLTGSLAVSALVFSLLK
>NZ_CP050994.1|WP_168235842.1|3093568_3093907_+|tRNA-binding-protein
MQTISWQEFEMVELRVGTLVRVEPFPEARKPAYKVWADFGPELGVRKSSAQITDLYQPDDLVGRQIVAVVNFPAKQIGPIQSEFLLTGFYRADGAVVMAIPEQAVENGAKLG
>NZ_CP050994.1|WP_005327165.1|3092376_3092700_+|met-regulon-transcriptional-regulator-MetJ
MGTEWNGDYVSPYAEHGKKSEQVKKITVSIPLKVLKVLTDERTRRQVNNLRHATNSELLCEAFLHAFTGQPLPCDDDLRKDHPDSVPAEARAIMEALGKEIEDFDAE
>NZ_CP050994.1|WP_111910522.1|3090903_3092082_-|cystathionine-gamma-synthase
MSHKATLAVRTGIETDTQHGAVVPPIYLSSNYTFADFGEPRQYDYARSGNPTRTNLADALAALEGGAGAVVTGTGMGAVHLVTTALLKAGDLLIAPHDCYGGTWRLFEYLAAKGHYRVQFVDQGDEAALAEALAQQPALVWVETPSNPLLRVVDVAAIAAASHEVGAKVVVDNTFLSPLLQQPLSLGADVVVHSTTKYINGHSDVVGGVAIAKDQTLAESLVWWANCLGLTSGAFDSYLTLRGLRTLAPRLRAHQENTDRILAFLQQQPLVKKIYHPSLPSHPGHEIARRQQSGFGAMLSFELDCNETGLRAFLAALRLFSVAESLGGVESLVAHPASMTHRAMTPAAQQAAGISAQLLRLSVGIEHGEDLVADLAQGFEQAQLAQQAEQVK
>NZ_CP050994.1|WP_163137615.1|3088435_3090904_-|bifunctional-aspartate-kinase/homoserine-dehydrogenase-II
MEQQQQGESAVAAERALKRRHVHKFGGSSLADPVCYRRVASILEQQAEQQGGGRELVVVSAAGKTTNRLIQLVELAEAGDEAAGEAITALHAYQQSLIDGLLEGELLLDLSQQLTDDMQQIAKTLEGQFDRFERNGLLAFGEVWSARLLAALLTSRGDKAIWLDARSFLRAEDGALVKVDAAISGELLKARLAEHPGRIVVTGFIAADMEGRSLLLGRNGSDYSASLLAALADGESTTIWSDVAGVYSADPRRVKEARLLERLSLAEANELARLGSSVLHSRTLQPVADSRQRLTLRCSYNPDEGCTHILRRAPRSGGARIVSSVDQIALIELKVLPQTGYEQTVAAIEAHLARHRLNPLTLQRQPDRRVLRLAYTLEVAEGAFEILRDFQLQGSFTGLIQKEGFSLVALVGAGVTDNAEQCHRFYQLLADQPLEFVQVARDGLSLVAVVRQVVLEPLLIALHSALFSRPTRVGLVVFGKGNIGGHWLALYAREKARLEHELNMALTLYGVFSSEGGLLDEEGLDPLKVRDNFNPRPLIWPELLGQLEQHGFDALIALDMTASETVSRYYPDFAQLGIHIIAANKFAGAADSEFYQRIKQSCRDHQVQWRYNATVGAGLPIQSSIQMLRQSGDRIQGVSGIFSGTLSWLFQQYDGTRPFSELVDEAWQHGLTEPDPREDLSGQDVRRKLLILAREAGFELDSADIELENLVPVSLRKVSTDQFMDRLKDLDDPIQTAFEGARRVGKVLRYVARFEHDGKARVGLETLEPHHPFANLLPCDNVFAIESDSYRTNPLVIQGPGAGREVTAAAIQYDLWQICASL
>NZ_CP050994.1|WP_168235841.1|3087678_3088368_+|LrgB-family-protein
MSDTLLGLLCFALTLLFYYASKWLYGKKRILPLMPLLLAPALLVAVVVLFHIPYQDYMAESHWLLWLLGPATVAFAVPVYENRALMRRHWLSLSVGVFASVLMAVGSTVLLARWLNLSELLQRSMAMRSITTPFAVEATRSVGGNADLTALFVVLTGVIGMAVGESVLTVLAIRSRLGKGAGFGASAHGAGTARAYQMGNEEGVVSSMVMMIAGMATVLLAPLLGKLFW
>NZ_CP050994.1|WP_042648380.1|3087284_3087686_+|CidA/LrgA-family-protein
MKAFCLRWLQTPFQIALLAAIWLLADTAVRTFHLPLPANLTGMLLLLVCILLGVVKAQWFSAGARWLLAEMLLFFVPAVVAVVNYQDLLLQEGWRIMVVLVTSTVLVLGTTALVVDRVYRLELKLARRSRRHV
>NZ_CP050994.1|WP_168235845.1|3098302_3099571_-|tyrosine--tRNA-ligase
MIDPHLLTDLTERGLVAQMSDPAALASHLATARTLYCGFDPTAGSLHIGHLVPLLMLRRFQLAGHTPVALVGGATGLIGDPSFKATERSLNSAETVQGWVASLSAQIRALLPASEGLAAPVLVNNADWMGQMSALDFLRDIGKHFSVNAMLARESVRQRLARPDQGISFTEFSYALLQSQDFAVLNQRLGCTLQIGGNDQWGNITSGMDLTRRLHQAQVHGMTLPLITKADGTKFGKTEGGAIWLDPALTSPYAFHQFWLGTADEDVYRFLRYYSFMSLAEIVALEAEDAGRQGRKQAQQVLADELTELVHGKGALAAARRIGELLFCGDVARLGEGDLAQLAQDGMPSCRIEEQRDLVTLLVESGLASSKRVARELLGAGAISLNGEIRQDEQLSAEDRLFERYLLLRRGKKQYRLVEWVD
>NZ_CP050994.1|WP_168235846.1|3099716_3100598_+|LuxR-family-transcriptional-regulator
MSQPLATDSLTQSLTAVVDALHSPAFAAALVRLIQQQVAFDCALLLGVGQRPVYLYDNLNHQRALLFDSYLTSHFSRDPFMQALKDGLPAGVWTLAQVSKGRLDPEYRHHFYQATGWQEEVGLILPVRGGLTLMLFLGRLDKRQSLRQEERARLEALFPLVHSLCCQQWREAVPLLAQRAATRATDSTAKSAAKSTAKDTVQGAPASLDGASLKAAVEQAMTSVGGDRLTRRERQVASLLLQGLDTEAIAAELGIGSGTVKNHRKHLYGKLRLGSRAELFSLFLNHLITTSTS
>NZ_CP050994.1|WP_168235847.1|3100651_3101422_-|chitin-disaccharide-deacetylase
MHKRLIINADDFGLCPAQSYGIVEAFEHGVVSSTTAMVNSPAIEHAAWLAKRFPDLPIGLHFVLSWGKPLSPLSCLVNAQGELDKSIWQKNEQGLLVAREIMEELRQQFDRFVTLFGRSPSHIDSHHHVHMLPSLYPLVEAFARQQGIAMRIDREEVRRHGLTVNHELSCQRFDSRFYGESLTRELLLQLLDDANEQGVNSLEIMCHPAFIDLEVQRSAYHQPRLTELAILTDPALPELIAARGYCLTSYQGWQPS
>NZ_CP050994.1|WP_168235848.1|3101470_3102817_-|6-phospho-beta-glucosidase
MNKTLKVVTIGGGSSYTPELVDGFIKRYAELPIDELWLVDVPEGQGKLDIIFDLCQRMIQKAGIPMTLHKTLDRRAALQGASFVTTQLRVGQLQAREKDERIPLSHGLLGQETNGAGGLFKGLRTIPVIFDIIRDVEEICPDAWLINFTNPAGMVTEAVHRHTHFRRFIGVCNIPVGMQMFVRDALKVSAEDSLSIDIFGLNHLVFIGDVLVNGVSRFDELLEGVIDGSLTSASSVKNIFDLPFDASLMRGLRLLPCSYLRYYFKEKEMLGIEMGEFYKGGARAQVVQQVEKTLFELYQNPELNEKPKELELRGGAYYSDAACEVISAIHNDKRSEQYVIIPHHGHVTNIPADWTVEMTCLVGRDGAIPHPRLTRFDDKVNGLIYLIKSFEIAASQAALSGSFDDLLLAMNLNPLIHSDNEAKIVAQELLLAHREHLPKFAAAIADLA
>NZ_CP050994.1|WP_042041464.1|3102970_3103798_-|transcriptional-regulator-ChbR
MSVKTIRENELFNNRPFHMFIYNKQVSGTGLHQHDYYEFTLVLTGRYYQEVNGKRVLLERGDLVFIPLGSSHQSFYEFGTTRIFNVGISRSYFDEHFKYLLPEHFVASQAYPLKHEFLSYIESVLVSPGFREEALTEFLEVVTYSVMNRLRHHKDASASEDLPLWLHEAVERMHDRPLFAEDALANLIHLSGKSQEYLTRATRRYYNKTPMQIINEIRVNYAKMQLEVTNDSVADIAFETGYNDVSLFIKNFKKLTSFTPGSYRKYLYPKFETPA
>NZ_CP050994.1|WP_106885756.1|3103830_3104184_-|PTS-N,N'-diacetylchitobiose-transporter-subunit-IIA
MFDMDHIEAETTTCDDMEEVVMGLIINSGQARSLAYSALKKAKEGDMAAARQLMTQSREALNAAHQVQTQLIESDQGEGKIPVTLVLVHAQDHLMTSMLARELINELIDVHEKLLGK
>NZ_CP050994.1|WP_168235849.1|3104240_3105623_-|glycoside-hydrolase-family-1-protein
MMYRFADDFWWGSASSAPQTEGASSRDGKSDNIFDYWHTIEPTRFHQGIGPAQASTFYDRFESDIALLKQLNHNSFRTSISWSRLIPDGTGEVNQQAVVFYHAVFDRLLAEGITPFINLYHFDMPLCMQEQGGWESRDVVAAYVRYASICFELFGSRIQHWFTFNEPIVPVECGYLGHFHYPCVVDFRRAVIVAYHTALAHAGAVKAFRDAHASGEIGIILNLSPTYPRSDSAVDRQAARWADLLLNKSFLDPALKGSYDPELVALLRQHDLLPEVEAGDKALLSAGRVDWLGINYYQPRRVKAKEQPCAGAPHTPEDLFDFYQMPGRKMNPHRGWEIYEKGVYDILTELRLGYGNPRCYISENGMGVEGEERFIGPEGRVEDDYRIDFIRGHLEWLHRGLQEGSACCGYHLWTFIDNWSWLNAYKNRYGLVRLDLESQTRTIKKSGYWFAEVARNHGFN
>NZ_CP050994.1|WP_168235850.1|3105677_3107039_-|PTS-N,N'-diacetylchitobiose-transporter-subunit-IIC
MSTMIASLEKAILPIAIKLGKQPHVNAIKNGFIKLMPLTLAGAMFVLINNVFLSFGEGSFFYSMGVRLDPATIATLDGFKSIGGSVYNGTLGIMSLMAPFFIGHAMAEERKVDPLSAGLLSVAAFMTVTPFSVGEAYAVGANWLGGANIISGMIIGLVSAEMFAFVIRRNWVIRLPDSVPTSVARSFSALIPGFIILSIMGIVAYLLQTEGTNFHQIIMDTISTPLSNMGGLVGWVYVLFSPLLWFFGVHGSLALSALENGILVPFTLENVALYTQYGSVEAAIAAGKTFHVWTKPMLDSYIFLGGTGATLGLILAVFMVSRRDDYRQVAKLGMPAGIFQINEPILFGLPVIMNPVLLIPFVMVQPVLATITLFAYNTGFIPPITNMAPWTMPAGLGAFFNTNGSIAAALLAIFNLGIATLMYVPFVLIANKAQAVIEEEQESEEDIALALKF
>NZ_CP050994.1|WP_168235851.1|3107049_3107370_-|PTS-sugar-transporter-subunit-IIB
MGKKRIYLFCSAGMSTSLLVSKMKAQAEKYDVPVEIDAYPETLAGEKGQDADLILLGPQIAYMLPEIQALLPGKPVEVIDSLLYGKVDGLGVLKAAVASIKKSLAQ
>NZ_CP050994.1|WP_168235852.1|3107968_3108727_-|GspN-family-type-II-secretion-system-protein-ExeN
MKQKVLIAALFLVAYLGFLLVTLPATLVVRHLPLPPNLVQLEGVSGTLWSGQIARLQYASESLTQLRWELDGWSLLRLAPEVSVRFGDRAGLNGQGVIGWNGAAFGRDITLNAPAPWLLARVPTRLPFPLTAAGQLQLKVDQFAQGKPWCEELYGNLNWYGAEADTPAGKLLLGDPELKLTCLDSRLVAELKQGSEAVQVQGKLELQANRQYLFQGTLKPGPALPDQMKQGLPFLGQPDGQGRFPLRYQGRI

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Crispr_ID: NZ_CP050994_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_18

3274985-3275079

Orphan

Consensus_repeat	Method
TGTTGAGGATGGAATTGAAGAGCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_18

>merge|NZ_CP050994|18|3274985-3275079|CRISPRCasFinder
TGTTGAGGATGGAATTGAAGAGCTGGATTTGATTGGTGCTGATACTCATGCCGGCCACCTCATCAGAACATGTTCAGGATGGAATTGAAGAGCTG

>NZ_CP050994|18|18|3274985-3275079|CRISPRCasFinder
TGTTGAGGATGGAATTGAAGAGCTG	GATTTGATTGGTGCTGATACTCATGCCGGCCACCTCATCAGAACA
TGTTCAGGATGGAATTGAAGAGCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_168236579.1\|3272182_3272986_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_168235921.1\|3267426_3267765_-\|LafX	unknown	unknown	unknown
NZ_CP050994.1\|WP_168235924.1\|3269713_3270580_-\|lateral-flagellin-LafA	unknown	unknown	gnl\|CDD\|139237
NZ_CP050994.1\|WP_168235934.1\|3282938_3283739_+\|lateral-flagellar-basal-body-P-ring-formation-protein-LfgA	unknown	unknown	gnl\|CDD\|180794
NZ_CP050994.1\|WP_168235930.1\|3276772_3277879_-\|lateral-flagellar-basal-body-P-ring-FlgIL	unknown	unknown	gnl\|CDD\|235399
NZ_CP050994.1\|WP_168235922.1\|3267885_3268278_-\|lateral-flagellar-export-chaperone-LafC	unknown	unknown	gnl\|CDD\|376819
NZ_CP050994.1\|WP_025328471.1\|3265860_3266319_-\|lateral-flagellar-basal-body-associated-protein-LafF	unknown	unknown	gnl\|CDD\|377123
NZ_CP050994.1\|WP_139745583.1\|3278558_3279344_-\|lateral-flagellar-basal-body-rod-protein-LfgG	unknown	unknown	gnl\|CDD\|183687
NZ_CP050994.1\|WP_168235933.1\|3280178_3281372_-\|lateral-flagellar-hook-protein-FlgEL	unknown	unknown	gnl\|CDD\|235862
NZ_CP050994.1\|WP_025328489.1\|3282074_3282500_-\|lateral-flagellar-basal-body-rod-protein-FlgCL	unknown	unknown	gnl\|CDD\|180702
NZ_CP050994.1\|WP_168235925.1\|3270774_3271635_-\|lateral-flagellin-LafA	unknown	unknown	gnl\|CDD\|139237
NZ_CP050994.1\|WP_163155602.1\|3282502_3282886_-\|lateral-flagellar-basal-body-rod-protein-LfgB	unknown	unknown	gnl\|CDD\|183682
NZ_CP050994.1\|WP_168235927.1\|3274066_3274966_-\|lateral-flagellar-hook-associated-protein-LfgL	unknown	unknown	gnl\|CDD\|235956
NZ_CP050994.1\|WP_163155604.1\|3281390_3282074_-\|flagellar-hook-capping-protein	unknown	unknown	gnl\|CDD\|235847
NZ_CP050994.1\|WP_168235931.1\|3277887_3278559_-\|flagellar-basal-body-L-ring-protein-FlgH	unknown	unknown	gnl\|CDD\|183507
NZ_CP050994.1\|WP_168235932.1\|3279433_3280168_-\|lateral-flagellar-basal-body-rod-protein-LfgF	unknown	unknown	gnl\|CDD\|183642
NZ_CP050994.1\|WP_168235920.1\|3266359_3267436_-\|flagellar-hook-length-control-protein-FliK	unknown	unknown	gnl\|CDD\|350657
NZ_CP050994.1\|WP_168235929.1\|3276365_3276764_-\|peptidoglycan-hydrolase	unknown	unknown	gnl\|CDD\|139168
NZ_CP050994.1\|WP_168235926.1\|3273045_3274047_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|197874
NZ_CP050994.1\|WP_168235923.1\|3268316_3269600_-\|lateral-flagellar-capping-protein-LafB	unknown	unknown	gnl\|CDD\|224264

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_168235933.1\|3280178_3281372_-\|lateral-flagellar-hook-protein-FlgEL	gnl\|CDD\|235862	PRK06803, flgE, flagellar basal body protein FlaE.	0
NZ_CP050994.1\|WP_168235924.1\|3269713_3270580_-\|lateral-flagellin-LafA	gnl\|CDD\|139237	PRK12802, PRK12802, flagellin; Provisional.	9.39105e-54
NZ_CP050994.1\|WP_168235934.1\|3282938_3283739_+\|lateral-flagellar-basal-body-P-ring-formation-protein-LfgA	gnl\|CDD\|180794	PRK07018, flgA, flagellar basal body P-ring formation protein FlgA.	1.84169e-39
NZ_CP050994.1\|WP_168235930.1\|3276772_3277879_-\|lateral-flagellar-basal-body-P-ring-FlgIL	gnl\|CDD\|235399	PRK05303, flgI, flagellar basal body P-ring protein FlgI.	0
NZ_CP050994.1\|WP_168235922.1\|3267885_3268278_-\|lateral-flagellar-export-chaperone-LafC	gnl\|CDD\|376819	pfam02561, FliS, Flagellar protein FliS. FliS is coded for by the FliD operon and is transcribed in conjunction with FliD and FliT, however this protein has no known function.	4.03553e-45
NZ_CP050994.1\|WP_025328471.1\|3265860_3266319_-\|lateral-flagellar-basal-body-associated-protein-LafF	gnl\|CDD\|377123	pfam03748, FliL, Flagellar basal body-associated protein FliL. This FliL protein controls the rotational direction of the flagella during chemotaxis. FliL is a cytoplasmic membrane protein associated with the basal body.	1.24763e-11
NZ_CP050994.1\|WP_139745583.1\|3278558_3279344_-\|lateral-flagellar-basal-body-rod-protein-LfgG	gnl\|CDD\|183687	PRK12693, flgG, flagellar basal body rod protein FlgG; Provisional.	1.46008e-146
NZ_CP050994.1\|WP_025328489.1\|3282074_3282500_-\|lateral-flagellar-basal-body-rod-protein-FlgCL	gnl\|CDD\|180702	PRK06802, flgC, flagellar basal body rod protein FlgC; Reviewed.	7.04837e-74
NZ_CP050994.1\|WP_168235925.1\|3270774_3271635_-\|lateral-flagellin-LafA	gnl\|CDD\|139237	PRK12802, PRK12802, flagellin; Provisional.	5.33848e-58
NZ_CP050994.1\|WP_163155602.1\|3282502_3282886_-\|lateral-flagellar-basal-body-rod-protein-LfgB	gnl\|CDD\|183682	PRK12685, flgB, flagellar basal body rod protein FlgB; Reviewed.	6.79496e-52
NZ_CP050994.1\|WP_168235927.1\|3274066_3274966_-\|lateral-flagellar-hook-associated-protein-LfgL	gnl\|CDD\|235956	PRK07192, flgL, flagellar hook-associated protein FlgL; Reviewed.	5.19955e-68
NZ_CP050994.1\|WP_163155604.1\|3281390_3282074_-\|flagellar-hook-capping-protein	gnl\|CDD\|235847	PRK06655, flgD, flagellar hook assembly protein FlgD.	2.51901e-38
NZ_CP050994.1\|WP_168235931.1\|3277887_3278559_-\|flagellar-basal-body-L-ring-protein-FlgH	gnl\|CDD\|183507	PRK12407, flgH, flagellar basal body L-ring protein FlgH.	1.97668e-88
NZ_CP050994.1\|WP_168235932.1\|3279433_3280168_-\|lateral-flagellar-basal-body-rod-protein-LfgF	gnl\|CDD\|183642	PRK12640, flgF, flagellar basal body rod protein FlgF; Reviewed.	1.0888e-110
NZ_CP050994.1\|WP_168235920.1\|3266359_3267436_-\|flagellar-hook-length-control-protein-FliK	gnl\|CDD\|350657	cd17470, T3SS_Flik_C, C-terminal domain of flagellar hook-length control protein FliK and similar domains. The flagellar hook-length control protein FliK is a soluble cytoplasmic protein that is secreted during flagellar formation. It controls hook elongation by two successive events: by determining hook length and by stopping the supply of hook protein. It contains an N-terminal domain that determines hook length and a C-terminal domain that is responsible for switching secretion from the hook protein to that of the filament protein, by interacting with FlhB, the switchable secretion gate.	6.68032e-18
NZ_CP050994.1\|WP_168235929.1\|3276365_3276764_-\|peptidoglycan-hydrolase	gnl\|CDD\|139168	PRK12708, flgJ, peptidoglycan hydrolase; Reviewed.	1.00859e-42
NZ_CP050994.1\|WP_168235926.1\|3273045_3274047_-\|hypothetical-protein	gnl\|CDD\|197874	smart00787, Spc7, Spc7 kinetochore protein. This domain is found in cell division proteins which are required for kinetochore-spindle association.	0.00901011
NZ_CP050994.1\|WP_168235923.1\|3268316_3269600_-\|lateral-flagellar-capping-protein-LafB	gnl\|CDD\|224264	COG1345, FliD, Flagellar capping protein [Cell motility and secretion].	5.75937e-46

>NZ_CP050994.1|WP_168235927.1|3274066_3274966_-|lateral-flagellar-hook-associated-protein-LfgL
MRISTNQIQLSMLDNLQHGFGEYARLDRQISSNKRILQPSDDPVGSVQLLGLKKEQAAMEQYQKNIANAKSQLSQGEIQLETMTNMLSRMRDLTQTAATGSLSEDDRRAVSSELAIIKDGLLDLANARNESGSSLFSGSQVDKTPIVKGPGGDYLYQGDALVREVGIARGVTVELNHTADKLFIQNGDFFKQLDSMVAAFDSGAADAADQARAMLDRSLTLQDDISQMVSTIGARINLLDQVDEGHAEKSTYSKEVSNRIESLDYEKAVTQQAHVLMALQVQQQAFAKVNGLSLFNYMP
>NZ_CP050994.1|WP_168235926.1|3273045_3274047_-|hypothetical-protein
MQIQQTRPGGVAETPAQPRLHGRSTAQASSQQTPRNERQPNVIRLDRWALIGTAQQRIAHAQGGEQALSQVWGELKRLEQQLGQHKTASGDLVSRLKLLEEKLTQPKAPLTSELKPRLLASATDSRVHYGAERLDLLSPRASAERLVFSFPQTSSAVEVLLPADASESEAASRLDRALRKEHIQARLNELGKLELSVPDQHRRKLDEPVLLSGEGIRIPAGNPVPVQFKQRAGQLTQLGEGLDKGELKQEQQRLKRLLGEIEQSVRELKQFRQKMVKQLDRVKSRSQSMPQEELAQLQGKLSLQLKEGGFMGTMSGLLAQANVSRQNVVALLT
>NZ_CP050994.1|WP_168236579.1|3272182_3272986_+|hypothetical-protein
MLSCPEVCRQLLLDPLAMQTEVTELAQPLPFATPPSTAMATLHSLSIHVLAATDVPVEIRLWLIGMLIHRDPSALSHESFLDQVAALAERGELNTMFEQLPALPQFQWWGLRTITGQLLAYSQGRRGRQTMQHCLDKINLVLEGVYDEGKLARLQQTWHDRVAPFLAERPHIMDNYLLYYVYHHNFPLLQSGRIQAYQLLVIDYFLLRNYLCLLAMDKELDEQDVINLFYSYHTIRQHNASFLKTIEQGLSESGFASDLSLYALLKP
>NZ_CP050994.1|WP_168235925.1|3270774_3271635_-|lateral-flagellin-LafA
MGLSIHTNFASLTTQNQLNSTNKMLGTAMQRLGTGLRINSAADDAAGLQMATRLQAQSNGQKVGMRNAQDAVSMMQTAEGAMDEMTNIVQRMKDLATQGANGTTSADDYTALNAEFGELTKELGNIVGNTSFGGQKLLKGGSFEAATGVTFQIGGSSTETLKVDVATAMKALTGTTATSGIADADIVAGIGDQTKASDAITATSNLLDQIGSVRSSFGANINRLEHTVNNLSNMKENTDMANGRIMDADFAQESTNMTKNQMLMQAGMSVLSNSNQMTGMVTSLLR
>NZ_CP050994.1|WP_168235924.1|3269713_3270580_-|lateral-flagellin-LafA
MGLSIHTNFASLTTQNQLNSTNKMLGTAMQRLGTGLRINSAADDAAGLQMATRLQAQSNGQKVGMRNAQDAVSMMQTAEGAMDEMTNIVQRMKDLATQGANGTSSAEDRLAMGTEMKALSAELKNISDNTKFGGQDLISDAGKFGVAAVTFQIGGSATEKLDVDATANVQAVNAAIDAAETDFGTADVAATALASTAFNTQITKMEDALDAIGTARSQFGANINRLEHTVNNLSNMKENTDMANGRIMDADFAQESTNMTKNQMLMQAGMSVLSNSNQMTGMVTSLLR
>NZ_CP050994.1|WP_168235923.1|3268316_3269600_-|lateral-flagellar-capping-protein-LafB
MQIDPASTARQLVTIERQNMEKLLKKQLDSVKGQQSAISSLTTKLSSFQTLLKDLNKATNLQAQKATMSQEGIMTVTSNGKASSGQYNFFVEQLAQSHQVGLQLDSDTAPLPADGVFSLTVKGKTMEIDLATLPAGATAKDLVSQINNAKDNPGVKATLVRTDGKVSMVLTSKDSGVENAITLDYSGDATNPLGMAVGSKTDITLAQDAKLRMGGDKPLTITSASNKIENVVDGLTFQLTKAQKADDAPLLVTVDQDKEAVTGSLKKFVDSYNELVDELAKMTSSDPKAPGALSSDSGVRSLKSMLARSVRDLPGDLTLGSLGIKTDKTGKLSFSETDFNKALEKDPELLGKALMGDDGLLKRMSNSLDPYTKRDGALKGRKTGLEANEKRINERMEALDRRMDSAYKRYLNQFTTMNQMLQTMGAL
>NZ_CP050994.1|WP_168235922.1|3267885_3268278_-|lateral-flagellar-export-chaperone-LafC
MFEPQEGYDAYQFAATQAKAASADPHQLVLMLMDGLLDEIARAEGHILVKQYERKGQSINKCLQILGGLDSALDMDKGGELATNLHRLYDYCGQRLFEISVGNDVAGFAEVRRILLELKEGWEAMARHPR
>NZ_CP050994.1|WP_168235921.1|3267426_3267765_-|LafX
MSMTGAVPPSTERETRQRQLLGLGRLILQQARAGQWDAVRLADHRLAQLVDHLRQQPALWQSLVPARDQVRHWHQEALALCQQETAQRKQEWDALSLKREGLQAYDEAQAWA
>NZ_CP050994.1|WP_168235920.1|3266359_3267436_-|flagellar-hook-length-control-protein-FliK
MGMIPFVGSDPAPNLDTTGFTRLARQPEGQEGQYQPLEFQQEAPVILPLDEASAPESEVEEADLPEQDPTEQLHAFTHMQPVFVRPDEGGRLLPLRQTPGMSSSLAPDAGGVQDDAPAVSPALRALVRHERLETDRHPPMDLVSGRREMSASLTGEFARQLMQPAAQVESSLLHGKSMAGLPSLPGADGSSERESLVSDLRGMSALAPSPLTRTADYQWAPARLTDNQTQWGQQLVDVLKDKLELQVNHGIKQAHIRLDPPELGRLELTVRVEGDRLSVQLNVTNPAVREAMIQSMERLRMSLAPHHAGGVEVNVGQGGEQERGDRWQQEKILAGRRQWQEEQDASGGAGQDWLNTLV
>NZ_CP050994.1|WP_025328471.1|3265860_3266319_-|lateral-flagellar-basal-body-associated-protein-LafF
MRRVMKWMMLMVMALCLLAALAYGAYLKRDTVAVWLGLAEAKPELSKTPLFKPMERFVISLEGDTEPHYLVLELALVTHNPQQLETLNELTPLIRNAMVQYFSHRSHDAVKLELQNISALQTSLLGKLVATLQGYGYKPYLDEVLVTKVLVQ
>NZ_CP050994.1|WP_168235929.1|3276365_3276764_-|peptidoglycan-hydrolase
MTRITSEPGFYQDLNELQQIKSNPDQRAALEAAAGQFEVSFLQTVLKHMRSASDAMQDEDDKLIKGEALYRDMYDSQLAMSMVKRGGMGLKEQMVNQLAPTLKNAEPVVASEPQTLAAFSQPLNSAKMRKVD
>NZ_CP050994.1|WP_168235930.1|3276772_3277879_-|lateral-flagellar-basal-body-P-ring-FlgIL
MNRWYIALLCLSLSGVAGAAAPAKRALLDIADVQGMRTNQLVGYGLVVGLSGTGDRSQVKFTGQSMANMLKQFGVQLPDDIDPKLKNVAAVSVQATLPALAGKGQLVDVTVTSIGDAKSLRGGSLLLTPMRGIDGEVYAVAQGNLVVAGVKAEGQSGSSVTINVPTAGIIPNGAIIEREAVSNFSDKPEVTLNLHQPNFKTARNVEREINRQLGPVAKAVSAGRIQIAAPRDDSQRISFMALLQDIQVDMGKERPRVVFNSRTGTVVMGLGVKVRKAAVSHGSLTVTIGESQTVSQPNAFSNGRTTTTPNSQVQVDRERNNMFVWPDGTSLEVIVKAVNSLGATPDDVMAILQALDEAGALEGELVVI
>NZ_CP050994.1|WP_168235931.1|3277887_3278559_-|flagellar-basal-body-L-ring-protein-FlgH
MMRAMWRCVVVSLLLGGCSTYELQAPEPGDEKWAPSRSEMTKTGKGEDGSLYRNDYMMTLFQDRRAYRIGDILTVMLEERTQSSKKANTSMNKNSSLNVPAPSIGGVSRPDWGASVTADRDFDGGATSSQQNTLAGAITVTVAEVMPNGVLGIRGEKWIRLNQGDEYIRLGGMVRVEDIDQSNRISSQRIADARITYAGRGALADSNQMGWLSRFFSSAFAPL
>NZ_CP050994.1|WP_139745583.1|3278558_3279344_-|lateral-flagellar-basal-body-rod-protein-LfgG
MHAALWVSKTGLSAQDAKMASISNNLANVNTVGFKRDRVAFEDLFYQVQRQPGAQQDQQNLSPIGIQMGNGVRVVGTQKVFTPGQFQNTNQELDMAVVGAGFFGVERPDGETAYTRNGQWHRNAEGLLVNADGLPMLPQIQIPDNATKIAIGTDGTVSATLPGQQENVELGRITLTNFSNPAGLEALGGNLYRATGASGEAIEGVPGEEAMGAIKQFTLESSNVNVVEEMVDMITTQRAYEMNAKVVSSADQMLKFVTQAL
>NZ_CP050994.1|WP_168235932.1|3279433_3280168_-|lateral-flagellar-basal-body-rod-protein-LfgF
MEKLIYTAMSGAQHTLMAQQIRANNLANVNTAGFRADFERASAYALAGDGYQSRVMAREEQAGTDFRAGALMQTGRKLDVAVRGEGFITVQTADGKEAYTRAGNLEVDGEGLLTLNGRPVLGDGGEMVLPAYRDLSFGKDGSLSITPPGGGARLDVGRLKLVNPDPADLVKGPDGLFRQRQGGDAEISEQVVLASGFLEGANVNAVDELISSMSLTRNFELQVKLMKAADDQARQGARLISGQG
>NZ_CP050994.1|WP_168235933.1|3280178_3281372_-|lateral-flagellar-hook-protein-FlgEL
MSFSIGLSGLRAVNQELSVISNNVANASTAGFKSSRAEFAAIYGGGQAGGVEMNNVSQNFDRNGDVTRTGRGLDLAISGNGFFVLKDGNGQTSYTRAGMFQRDASNYLTTASGTRLQGYTTNEAGELQSGVVGDIQVKTGSLPAKPSDSLEFVANLKADASVIDQAVHPFDPAKSDSFSYSQSSKVYDSLGVEHTVTQYFVKTGDNSWQVNYAFNGAKTGTPVAMEFNTNGTLKTPTTAPVLNLAPAGADPISLKADLAKVSQYASDFNATRNQSNGYTSGDLTGVRVDADGGVYATFTNGQSLLQGQVVMANFTNPNGLLQTNNTTWQQSFSSGQPVLGAPGTGTLGGLTAGAYEASNVDLTGELVSLMTSQRNYQANAKTISSADKMTQVLFNSF
>NZ_CP050994.1|WP_163155604.1|3281390_3282074_-|flagellar-hook-capping-protein
MSLPQVSGLDTARSASQYSATPDIASNNTTAGQGVQLRNEFLQMMVAQIQNQDPTNPLDGAQYVTQLAQFSMVEGVEGLKVLQQKSINMMDTQQVLQSTNLIGQEVMVPSQTLNQQKEGVIRGQLELAGAADTVELKVYDKHGTLVATKGWGESKAGALDYALPTLPAGEYSFEVKASLAGVATTTKNYVASEVERVNLPGTGEIMLQVAGVGDVPLFSAVQFGKSA
>NZ_CP050994.1|WP_025328489.1|3282074_3282500_-|lateral-flagellar-basal-body-rod-protein-FlgCL
MSFNRIYDIAGSAMRAQTVRLDTVASNLANVDSAAGSEDAAFRAIKPVFSTLYQRVQDAEGLGAAQVQIAGIVQSDRQVEKRLEPTNPLADGDGFVYYSNVNAVEEMADMMSASRGFETSVEVINRINSMQQGLLRLGQGA
>NZ_CP050994.1|WP_163155602.1|3282502_3282886_-|lateral-flagellar-basal-body-rod-protein-LfgB
MSISFDSALGVHPYALDVRADRARILAGNLANVDTPGYLARDVDYKSILGRVARQVAAGEQGSAISQGDTDMQHPLYRIPYQVSMDGNTAELSVEQSKFASNATDFQTSLTFLNMKITGIAKAIEGR
>NZ_CP050994.1|WP_168235934.1|3282938_3283739_+|lateral-flagellar-basal-body-P-ring-formation-protein-LfgA
MPIVKIPYFRWSGHRLRPRAQAKGEALFPTWKRGGLLALLILALPLRAEPEPLAQRLTDGLKEDAALALRDYLQQQGWPDTQADYQVWLSPAVAHLPPCQQAVRYQAGGQYRQPWGRRPYLVECTEPAWQLRARVEVTLMLPVWVTAQEIQKGQTIGPGDLLEKSLDVSRLQRGFVPSNESLVGSKSTRHLRMGQLIGELDLQLAWAVRAGEGVLIRAGQQGFSATTRGTALTNAAIGEGVRVRNLSSGKEIQAWVIDKGEVETRF

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Crispr_ID: NZ_CP050994_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_19

4063460-4063549

Orphan

Consensus_repeat	Method
TATTCGTGTTCGAACATCAGGAACAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_19

>merge|NZ_CP050994|19|4063460-4063549|CRISPRCasFinder
TATTCGTGTTCGAACATCAGGAACAGCTAGACCACGAACGCCACCGCTGAGCGCTGGCGCCGGCTATTCGTGTTCGAACATCAGGAACAG

>NZ_CP050994|19|19|4063460-4063549|CRISPRCasFinder
TATTCGTGTTCGAACATCAGGAACAG	CTAGACCACGAACGCCACCGCTGAGCGCTGGCGCCGGC
TATTCGTGTTCGAACATCAGGAACAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_168236237.1\|4061854_4063387_+\|histidine-ammonia-lyase	unknown	unknown	gnl\|CDD\|236484
NZ_CP050994.1\|WP_168236235.1\|4059145_4060084_+\|formimidoylglutamase	unknown	unknown	gnl\|CDD\|237500
NZ_CP050994.1\|WP_106887810.1\|4071281_4071929_+\|MSHA-biogenesis-protein-MshJ	unknown	unknown	gnl\|CDD\|309474
NZ_CP050994.1\|WP_005323432.1\|4053929_4054883_+\|cell-division-protein-FtsX	unknown	unknown	gnl\|CDD\|182910
NZ_CP050994.1\|WP_168236246.1\|4074149_4075040_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|132060
NZ_CP050994.1\|WP_025325421.1\|4055347_4056202_+\|RNA-polymerase-sigma-factor-RpoH	unknown	unknown	gnl\|CDD\|235838
NZ_CP050994.1\|WP_025325422.1\|4056386_4057046_+\|carbonate-dehydratase	unknown	unknown	gnl\|CDD\|238448
NZ_CP050994.1\|WP_106885210.1\|4053160_4053832_+\|cell-division-ATP-binding-protein-FtsE	unknown	unknown	gnl\|CDD\|225438
NZ_CP050994.1\|WP_106887812.1\|4057057_4057762_+\|histidine-utilization-repressor	unknown	unknown	gnl\|CDD\|188194
NZ_CP050994.1\|WP_168236241.1\|4068808_4069756_-\|1-aminocyclopropane-1-carboxylate-deaminase/D-cysteine-desulfhydrase	unknown	unknown	gnl\|CDD\|225313
NZ_CP050994.1\|WP_168236240.1\|4066828_4068748_+\|RNase-E-specificity-factor-CsrD	unknown	unknown	gnl\|CDD\|236833
NZ_CP050994.1\|WP_168236243.1\|4070688_4071282_+\|PilN-domain-containing-protein	unknown	unknown	gnl\|CDD\|377469
NZ_CP050994.1\|WP_168236236.1\|4060149_4061853_+\|urocanate-hydratase	unknown	unknown	gnl\|CDD\|235448
NZ_CP050994.1\|WP_168236242.1\|4069825_4070692_+\|MSHA-biogenesis-protein-MshI	unknown	unknown	gnl\|CDD\|227306
NZ_CP050994.1\|WP_168236245.1\|4072306_4073986_+\|pilus-(MSHA-type)-biogenesis-protein-MshL	unknown	unknown	gnl\|CDD\|274176
NZ_CP050994.1\|WP_168236247.1\|4075036_4076179_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NZ_CP050994.1\|WP_168236234.1\|4057917_4059153_+\|imidazolonepropionase	unknown	unknown	gnl\|CDD\|236478
NZ_CP050994.1\|WP_168236239.1\|4064789_4066343_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NZ_CP050994.1\|WP_168236233.1\|4051214_4052963_+\|signal-recognition-particle-docking-protein-FtsY	unknown	unknown	gnl\|CDD\|236686
NZ_CP050994.1\|WP_168236244.1\|4071921_4072236_+\|general-secretion-pathway-protein-GspB	unknown	unknown	gnl\|CDD\|339769

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_168236237.1\|4061854_4063387_+\|histidine-ammonia-lyase	gnl\|CDD\|236484	PRK09367, PRK09367, histidine ammonia-lyase; Provisional.	0
NZ_CP050994.1\|WP_168236235.1\|4059145_4060084_+\|formimidoylglutamase	gnl\|CDD\|237500	PRK13776, PRK13776, formimidoylglutamase; Provisional.	0
NZ_CP050994.1\|WP_106887810.1\|4071281_4071929_+\|MSHA-biogenesis-protein-MshJ	gnl\|CDD\|309474	pfam04350, PilO, Pilus assembly protein, PilO. PilO proteins are involved in the assembly of pilin. However, the precise function of this family of proteins is not known.	0.00380035
NZ_CP050994.1\|WP_005323432.1\|4053929_4054883_+\|cell-division-protein-FtsX	gnl\|CDD\|182910	PRK11026, ftsX, cell division ABC transporter subunit FtsX; Provisional.	1.13138e-77
NZ_CP050994.1\|WP_168236246.1\|4074149_4075040_+\|AAA-family-ATPase	gnl\|CDD\|132060	TIGR03015, pepcterm_ATPase, putative secretion ATPase, PEP-CTERM locus subfamily. Members of this protein are marked as probable ATPases by the nucleotide binding P-loop motif GXXGXGKTT, a motif DEAQ similar to the DEAD/H box of helicases, and extensive homology to ATPases of MSHA-type pilus systems and to GspA proteins associated with type II protein secretion systems. [Protein fate, Protein and peptide secretion and trafficking].	2.11615e-74
NZ_CP050994.1\|WP_025325421.1\|4055347_4056202_+\|RNA-polymerase-sigma-factor-RpoH	gnl\|CDD\|235838	PRK06596, PRK06596, RNA polymerase factor sigma-32; Reviewed.	0
NZ_CP050994.1\|WP_025325422.1\|4056386_4057046_+\|carbonate-dehydratase	gnl\|CDD\|238448	cd00883, beta_CA_cladeA, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	3.19406e-122
NZ_CP050994.1\|WP_106885210.1\|4053160_4053832_+\|cell-division-ATP-binding-protein-FtsE	gnl\|CDD\|225438	COG2884, FtsE, Predicted ATPase involved in cell division [Cell division and chromosome partitioning].	1.51758e-124
NZ_CP050994.1\|WP_106887812.1\|4057057_4057762_+\|histidine-utilization-repressor	gnl\|CDD\|188194	TIGR02018, Histidine_utilization_repressor, histidine utilization repressor, proteobacterial. This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions].	1.65918e-96
NZ_CP050994.1\|WP_168236241.1\|4068808_4069756_-\|1-aminocyclopropane-1-carboxylate-deaminase/D-cysteine-desulfhydrase	gnl\|CDD\|225313	COG2515, Acd, 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism].	9.13305e-60
NZ_CP050994.1\|WP_168236240.1\|4066828_4068748_+\|RNase-E-specificity-factor-CsrD	gnl\|CDD\|236833	PRK11059, PRK11059, regulatory protein CsrD; Provisional.	0
NZ_CP050994.1\|WP_168236243.1\|4070688_4071282_+\|PilN-domain-containing-protein	gnl\|CDD\|377469	pfam05137, PilN, Fimbrial assembly protein (PilN).	0.00175381
NZ_CP050994.1\|WP_168236236.1\|4060149_4061853_+\|urocanate-hydratase	gnl\|CDD\|235448	PRK05414, PRK05414, urocanate hydratase; Provisional.	0
NZ_CP050994.1\|WP_168236242.1\|4069825_4070692_+\|MSHA-biogenesis-protein-MshI	gnl\|CDD\|227306	COG4972, PilM, Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion].	4.28997e-05
NZ_CP050994.1\|WP_168236245.1\|4072306_4073986_+\|pilus-(MSHA-type)-biogenesis-protein-MshL	gnl\|CDD\|274176	TIGR02519, related_to_type_II_protein_secretion_protein, pilus (MSHA type) biogenesis protein MshL. Members of this family are predicted secretins, that is, outer membrane pore proteins associated with delivery of proteins from periplasm to the outside of the cell. Related families include GspD of type II secretion (TIGR02517), the YscC/HrcC family from type III secretion (TIGR02516), and the PilQ secretin of type IV pilus formation (TIGR02515). Members of this family are found in gene clusters associated with MSHA (mannose-sensitive hemagglutinin) and related pili, and appear to be the secretin of this pilus system. [Cell envelope, Surface structures].	1.15536e-85
NZ_CP050994.1\|WP_168236247.1\|4075036_4076179_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	2.24151e-08
NZ_CP050994.1\|WP_168236234.1\|4057917_4059153_+\|imidazolonepropionase	gnl\|CDD\|236478	PRK09356, PRK09356, imidazolonepropionase; Validated.	0
NZ_CP050994.1\|WP_168236239.1\|4064789_4066343_-\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	2.87973e-83
NZ_CP050994.1\|WP_168236233.1\|4051214_4052963_+\|signal-recognition-particle-docking-protein-FtsY	gnl\|CDD\|236686	PRK10416, PRK10416, signal recognition particle-docking protein FtsY; Provisional.	0
NZ_CP050994.1\|WP_168236244.1\|4071921_4072236_+\|general-secretion-pathway-protein-GspB	gnl\|CDD\|339769	pfam16537, T2SSB, Type II secretion system protein B. This is the B protein from some operons of bacterial secretion systems of type II. The exact function of the B protein is not known, though in the case of Vibrio cholerae there is a fusion protein between proteins A and B that includes an AAA domain, a PG_binding domains well as this domain at the C-terminus. Many of the other species have no A or B domain genes in this operon. The type II secretion pathway is conserved in Gram-negative bacteria that are prevalent in bacterial pathogens of plants (Pseudomonas fluorescens, Erwinia or Xanthomonas species), animals (Aeromonas hydrophila) and humans (Klebsiella oxytoca, Pseudomonas aeruginosa, Vibrio cholerae or Legionella pneumophila). Typical type II secretion systems (T2SSs) are encoded by a set of 12 to 16 gsp (general secretion pathway) genes organized into large operons including the conserved 'core' genes denoted C to O and in some bacterial species, as indicated above, extra gsp genes such as gspAB, gspN or gspS. A different nomenclature is used for Pseudomonas T2SSs, so the B gene is referred to as the P protein.	0.00231542

>NZ_CP050994.1|WP_168236237.1|4061854_4063387_+|histidine-ammonia-lyase
MFELNLQPGKLCLATLRRVSREPVHVSLDSSALPGIHASAAVVTKVIEQNRVVYGINTGFGLLANTRIPVEQLDELQRSIVLSHAAGIGEYMDDATVRLMMVLKVNSLARGFSGIRLTVLEALMTLINAEVYPVVPKKGSVGASGDLAPLAHMSCLLIGEGKARHKGELIDAATALKIAGLEPIALAPKEGLALLNGTQASTAFALEGLFHAEDLFAGAITIGAMSVEAALGSRRPFDARIHEVRGQRGQIDAAACYRHLLVDGSEIGMSHHNCEKVQDPYSLRCQPQVMGACLAQIRHAAEVLVCEANAVSDNPLVFAEDEEILSGGNFHAEPVAFAADNLALAIAEIGSLSERRMALLIDSRMSGLPAFLVNNGGVNSGFMIAQVASAALASENKTLAHPASVDSLPTSANQEDHVSMATFAGRRLADMAENTRGILAVELLAAAQGLDFRAPLRSTELIELAKGRLREEVSFYDKDRYFSPDIEAAAALLGRASYNDLIPAGILPSL
>NZ_CP050994.1|WP_168236236.1|4060149_4061853_+|urocanate-hydratase
MSVQHQDPRHDPSRVIRAPRGTELTAKSWLTEAPLRMLMNNLDPEVAEHPQSLVVYGGIGRAARNWACYDKIVEVLTRLEEDQTLLVQSGKPVGVFQTHKDAPRVLIANSNLVPHWANWEHFNELDKKGLMMYGQMTAGSWIYIGTQGIVQGTYETFFAVANQHFNGEPKGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKAHSLDEALAMVEEAKRSGSAVSVGLLGNAADVFAELVARGITPDVVTDQTSAHDPIHGYLPQGWSVAQWRELQKSAPQEVNQAARHSMARQVEAMLTLQARGAATLDYGNNIRQMALEEGVKNAFDFPGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYKTDQKVKELIPDDPHLHNWLDMARERIAFQGLPARICWVGVKDRVRLGLAFNEMVKNGELKAPVVIGRDHLDSGSVASPNRETESMMDGSDAVSDWPLLNALLNTAGGATWVSLHHGGGVGMGFSQHSGVVIVCDGSDDAARRVGRVLRNDPATGVMRHADAGYEIAINCAQEAKLDLPMLNTAGKGVK
>NZ_CP050994.1|WP_168236235.1|4059145_4060084_+|formimidoylglutamase
MDKFNVADMSVWQGRQDPEDGELALRWHNKVQPWQADSEPGVVLIGFACDEGVRRNKGRVGAAAAPLAVRKLLANSAWHLGRPVHDGGDVRCENGDLDAAHDRLAERVARALDLGHFPLVLGGGHEVAFGSWSGLNRHLGGKGRVGIINFDAHFDLRMKQEQASSGTPFFQIAEQCAAQGTPFTYACLGVAETANTQALFVRADQLGVWYALDEAMTQAALPEILNGLDAFIARCDHLYLTIDLDVLPAAVMPGVSAPAARGVELTVIEPLIAHIRASGKLRLADLAEYNPSLDLDNRSARVAARLVHQLTK
>NZ_CP050994.1|WP_168236234.1|4057917_4059153_+|imidazolonepropionase
MNKELLNCERVWLNVTPATLRSDLADYGLLEPHALGVHEGRIHTLVPMQDLKGPHPAHWRDMKGRLVTPGLIDCHTHLIFAGSRAEEFELRQQGVPYSDIARKGGGILSTVRATRAASEDQLYELAVPRIKSLIREGVTTVEIKSGYGLTLADELKMLRVARRLGEALPIRVKTTLLAAHAVPPEYRDDPDSWVETICQEIIPAAAEAGLADAVDVFCEHIGFSLAQTEQVYLAADQYNLAVKGHMEQLSNLGGSTLAANFGALSVDHLEYLDQDGIQALAHRGVVATLLPTAFYFLKETKLPPVAALRKAGVPMAVSSDINPGTAPIVSLRMAMNMACTLFGLTPVEAMAGVTRHAARALGEQERLGQLRVGMQADFLVWNCAHPSEISYLIGVDQLVSRVLNGEETLHG
>NZ_CP050994.1|WP_106887812.1|4057057_4057762_+|histidine-utilization-repressor
MAPALYLQIKQHILDGIRERHYQAGDRIPTEAALCEQFAVSRMTVNKALRELVAEGWLNRTAGSGSFVADRRAESPLLAIRNIADEIAERGSQYSARVIRLQRQAADEKVAVRLGLRVGAPTFHSLIVHQADGEPLQLEERFVDAERLPGYGEQDFTKQTPNSYLMEVCPLSEMEHVVEAVLPSAGEAGLLQVRVDTPCLLLHRRTWSDGFLVSYARLLSPGSRYKLSSKTRLT
>NZ_CP050994.1|WP_025325422.1|4056386_4057046_+|carbonate-dehydratase
MKLLNDLFTNNREWAERIKAEDPDFFATLSAQQAPEYLWIGCSDSRVPANQLMGLLPGDVFVHRNVANLVVHTDFNCLSVLQYAVEVLKVKHIIVCGHYGCGGVKAAMQNQELGLIDNWLRNIKDVYFKYGEQLEAIEDEHERFDYLCELNVAEQVANVCHTTIIQNAWRKGQELAVHGWIYGIKDGLLHDLDLCISGPDQIPDVYRAWPDMRPPHRRR
>NZ_CP050994.1|WP_025325421.1|4055347_4056202_+|RNA-polymerase-sigma-factor-RpoH
MGTSLQRTMALIPQGSLEGYIQAVNSIPVLSAEEERELAMRLQQGGDLEAARQLVMSHLRFVVHVAKSYSGYGLPQADLVQEGNIGLMKAVKRFDPSVGVRLVSFAVHWIKAEIHEYVLRNWRMVKVATTKAQRKLFFNLRKSKKRLGWLNHEEVQAVAADLGVSAADVTEMEARMSNYDQAFDLVGDDEDEGGFAPVHYLEDKSSDLAATIENDNWDSHATRRLSAAMATLDERSQHIIRARWLDEESKTTLQELADNYGVSAERVRQLEKNALKKLKDAMAA
>NZ_CP050994.1|WP_005323432.1|4053929_4054883_+|cell-division-protein-FtsX
MAIVRHKQPPLRRLMMYGVDHVRQAFASLGELWRNPLASLMTLAVLGVSLALPSCFHVLLKNAEVVEGSWQTSSQISLYLRKDLPEQSILDMKQRILLYPEVESVTYMNRDEALKEFREISGFGDALDYLDSNPLPPVLSVIPDPRWQNPEGAAELLAKLENEPGIEQGKLDLQWLTRLQGIMNLLRHTITGIAVLLLSAVLLIVGNTLRLNILNQRSEIEVLKLVGATDAFIHRPFLYTGIWFGVIGGMLAWWLTEVMVIWSEGVVKELAGLYNSNFRLVGMGAFDGFNLILLGALLGLIASWFSVHRHIRDIEPS
>NZ_CP050994.1|WP_106885210.1|4053160_4053832_+|cell-division-ATP-binding-protein-FtsE
MIRFDKVSKVYSGGHQALQKVSFHLRKGEMAFLTGHSGAGKSTLLKLISVMERPTDGRVFFHGDDVSQIQRSQIPYVRRQIGMIFQDHRLLMDRTVFDNVALPLVIDGYSHADINKRVAAALDKVGLLGKERYQPRMLSGGEQQRVGIARAIVNKPPLLLADEPTGNLDPQLSMDIMRLFEEFNRFGVSVLIATHDLGLIARMRYRTLTLKAGRMYSQEQEES
>NZ_CP050994.1|WP_168236233.1|4051214_4052963_+|signal-recognition-particle-docking-protein-FtsY
MAKGLFSWLGFGRKKEEAEAVQSQAPDATPAVAESEATAAPAPVADVSLTEAPAVPHEAPLATPDEGPLVVEEPASELEPVIVNEALIAAEAEAQAAEAASVAAEAQAVEAARVAAEAQAAEAARVAAEAQAAEAARIAAEAQAAEAARVAAEAEAAEAARIAAEAQAAEAARVAAEAQAAEAARIAAEAEAAEVARVAAEARAAEEARIAAEARAAEEARIAAEAQAAEEARIAKEAQRAEDLRLVAEMEAEAAALAALPLAAKVDDDTQDKPQREGFFARLKRSLVRTKENIGSGFFGLFRGKKIDDELFEELETQLLTADLGVDTTTRIIEGLVQHADRKQLKDAEALYGLLKQDMGAMLTQVEQPLVIDTSKKPYVILMVGVNGVGKTTTIGKLAKQFQADGKSVMLAAGDTFRAAAVEQLQVWGQRNNIPVIAQHTGADSASVIYDAIEAARSRGADVLIADTAGRLQNKSNLMEELKKVVRVMKKLDEEAPHEIMLTLDAGTGQNALSQAKLFSEAVGLTGITLTKLDGTAKGGVIFAVADKFQIPIRYIGVGEGIDDLRPFVANDFIEALFSRDE
>NZ_CP050994.1|WP_168236239.1|4064789_4066343_-|EAL-domain-containing-protein
MHPSGRYPLRRASPFWISLLLLCLPVLASLPLSQLLGNPLAHQLLQQKKAQIEAALAERHEALDQSIRSQLSRFAFDCGPADMALLRDPRFYSRHIRLQGLKLASGGGCSSLGEDFPLATVELPPYPEQEQFGLAATQPRFNTEQEVVAYYRKGGNVAYWVLNNSWSHDQLQSPCTGCFYLEFGQQSTGKVTTFFPRGDKSIKQEPGNQSLSFFDPDPQIRQTLWAGKALEEYAKRQARHYGLLYGGALGLLLVAAYWVLRNYRRSLKGLLQAALVRREFVPFYQPIVDSRSKKVVGFEALLRWQRGRELVPPGTFIDYAEEQGLILPMTEQLLERVIADLPWLEPTQWVSVNIVAAHLEQPNLRPLLQRHDWPSPARLTFELTERKPITDIKAAMGEIAQLQEKGYHFKLDDFGTGYGGFAYLQRLGIRQIKIDKMFVDTIGTDDLKRTLLDSIIAFGHESNMEMIAEGVETLEQVDYLHRHGVHLIQGYVYAKPMALTKLKIWLLAWRQSQPGGQ
>NZ_CP050994.1|WP_168236240.1|4066828_4068748_+|RNase-E-specificity-factor-CsrD
MKLTTQLVSFITLCVISAMAVVMLGGVFSFRQMGMELQQNRVDSLVEIIDKQLGVTDDQQALARWLPSLLRASHVVELEIRQDSQRVYWFRDVQQQTDESLLIPYSKAIPNQAGMQAEFKLDRPFKEFEYSMQAMFGISLGVFIVVFGLWYSIRWLRQQLRGAELLAERAQLILDGKLTKLAHDPADEWPLSASQALTHLLAELADARKERSRFDNFIRSNAFVDKTTGIGNRLFFDNRLENAIMEASVISGGVLLIELAGLEELDPELNGRPSQDLLMEASASIGTFVRKHSGALQARYAGQVFAVLLPNMSESEMVDGASQLLKSLQRLHWPESVNLETAVYLGAVCYQAEDSLLKVQEEAELALKSARLQGHSGWFLYEKSLDEEASNKGTVRWRTLINRRIEEQGISFYLQSVQQERDQVVLQQELLIRLHDEQGRELQAGVFMPMAEKAGLLLPLDRLVVTQTLRLLRQRPESSCPVSLSLSAQNLLNREFQRELFFELFQLPRSINEGLILQLSESQVTRHYEALKRPLRALRMLGCRLAIDHAGQDVVSTQYIKEFEIHFLKLHPSLVREIHLRQVNQMAVRSLVGGCANTQARVIAVGVESGDEWKMLRHLGVHAGQGPWFAEPERLVMPA
>NZ_CP050994.1|WP_168236241.1|4068808_4069756_-|1-aminocyclopropane-1-carboxylate-deaminase/D-cysteine-desulfhydrase
MTNDALTAKRASLGDAILAPAQLPSPLHPIHHPLLDAQGVRLWCKRDDLIHPTLSGNKWRKLKYHLQQAQAQGKTHLLSFGGAYSNHIHALAAAGLRSGLRTTGIIRGEADTVSNATLSAAKGWGMDLVFVDRQSYRRRQDPDWLAQFEAPDTLIVPEGGSSPLAIPGVAELVAEVPFSPDLWVLPCASGGTLAGLIAGKRERERILAIAVLKGGAFLHDEVCRLNPAAATTSGWRIAQDHHDGGYARFSPALWQWVQAFSAHTGLPLEPIYSGKAMWGLFRELAAGRIPRGSQVVFIHTGGLQGLAGLREQGRL
>NZ_CP050994.1|WP_168236242.1|4069825_4070692_+|MSHA-biogenesis-protein-MshI
MKSLFRRSPPSHQVGLLLASDRILLACVEPVPIFTSRAINGPNDWPKAMGELFAQHGLAKSKVRVALAASLYQQIQIDKPAVPDAEMAGALPWAIKDFVNEPVLQLAMDYVDLPTPPAGRPRINVICVPKSRVQQLADAVNGVATLEAIVSDELAMTALYEADQTVRMLLWQPKGQELQLLVFYRGGLCFSRPLRGFVSLTGAHEPDQGMLDGLTLEIQRSLDYLAGQLKLPEPGQMQLAIGSPFIGTLVRHLEQAFGFPVSAMANKAVLAGVEYLSAYGAALGRSEG
>NZ_CP050994.1|WP_168236243.1|4070688_4071282_+|PilN-domain-containing-protein
MKHHINLYGAEFRPRRLWASLNQMALVWGGCLLLLIAATFFYGWQQRGVDRELAQVRALLDVQRSEASRLDAALARHQADGQLQQQLVNKREELAAKQALIRQLGSLSLQKSQGYASVMADLARLRDARLSLQRIEISDGHINLSGVAERSQDVPAWVNRFKQTPSLAGKQFGELTLSRDKAGQLAFQLSGIARETP
>NZ_CP050994.1|WP_106887810.1|4071281_4071929_+|MSHA-biogenesis-protein-MshJ
MEMTAQWRAWAQRVAALSLRERVLILLTGTILLGAAGIYGWLDAADTRLSQERQALTAAQRDLEILTLENQGKQARLGRDPNAQVRQQLAGVEASLGRLDAELKAQTVDLIPAHEMPAVLEALLSRSANLHMLALTSLKPEPLMAGEQKANLFKHGIRLQLEGGYFDVYQYLKALEALPRHFYWKGFDYRVVEHPKAAVEMEIYTLSTSKEFIRG
>NZ_CP050994.1|WP_168236244.1|4071921_4072236_+|general-secretion-pathway-protein-GspB
MAKWLTLLCCLLGPLAQAEVLQDPTAPLAGSGVAASPSKGAGLPRLQSVILGNGPALAVLNGQSYRVGQRIDGFLLVGISADAVVLEKAGKRQTLTLFGSKIRM
>NZ_CP050994.1|WP_168236245.1|4072306_4073986_+|pilus-(MSHA-type)-biogenesis-protein-MshL
MKKHHFCLLPLALAVAACTSYQHPEPVQAKDALKQAMKEQTPTAPLTTLPPSVQSELLQLNRPQQPLAVPEKRLRIAAHDVDAVEFFGSLFKGSRYSVAVHPGVAGAISVELKDVTLQEALATVGDMYGFDVQRKGNVFHVYPAGLRTETIPVNYLMMARRGLSRTSVSTGGVTANDNNNNGNNNFDSSGNNNNGNNNLGSSNGDNGSSNNSNGTQIETDSNNDYWSDLRDALQTLIGTGEGRAVITSPQAGLVTVRAYPKELKAVREFLDQSGEHLKRQVVLEARILEVALNEGYEQGVDWSGLSASWDGNKGITGGGSLLDSPIASTPNQIFRALGGGAGFTISDGNFNVAVSLLKTQGDVNTLSSPRVTATNNQKAVIKVGTDEYFVTNASTTTTTSGNSAPIVTPNVELTPFFSGIALDVTPQIDEAGRVLLHIHPSVIDTEEQSKTINVGTADPLVLPLAKSSIRESDTVVQANNGDIIVIGGPMKTDKQEIVSKVPLLGDIPWVGEAFTNRRESTKKVELVILLKPTVVEKDTWQKELQRSSELLDKWYPPKG
>NZ_CP050994.1|WP_168236246.1|4074149_4075040_+|AAA-family-ATPase
MYLNHFGLQEAPFGLTPNTGFYYGLPPHEEAMQVLNWALAQGEGFIKVTGEVGTGKTLLCRKLLSELGSEACPVRLAWLPNPHLSPGELRTALALELGLAVQGDSELDLTDRIHRHLIALHQQGSRVVVLIDEAQALPDETLEAIRLFGNLETESSKLLQIVLFGQPELDVRLARPHLRQLRQRIGFSYCLRPLRCDETRAYLEHRLHVSGYRGATLFGGLALRLLWRASRGIPRLINVLAQKCLMLAYGRGERRIGSRLVRLAIRDTDDASHLSFIRWWPLLLLLGGALVYGVWS
>NZ_CP050994.1|WP_168236247.1|4075036_4076179_+|tetratricopeptide-repeat-protein
MSVINQMLRDLEQRQGGTEAAVYVAPVRRQGWWMLVLTLLCGLAIGILGWRTWIYWQQSQRVQIPTAMADVLQSYDAASHTKAASSSVTAPAVMPLSAALALSTSEAATVADTPAAGTREPVALADLPAADDEPPAPQLEPEERVDDEVVPSDEELQPDLQAELAAEQEAIAAAPPRKPGVLKIETVDLSEPELAALAERKATTAMAKGQMREAQDNYYQVLAHDPHNQGAREQLAGLLYGEGRLTEAGQVLEEGLRLAPQQADFRLLLARVAIGEGDRQKALDWLTGYQPDLAANLDYYATWAGLAQELGQPAQASELYVKLLRQQPDQGRWWLGLGVAEDGQGHRQRALDAYGNAQLHGNLGEASTRWLEQRIAELTP

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Crispr_ID: NZ_CP050994_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_20

4074070-4074195

Orphan

Consensus_repeat	Method
ATGTACCTGAACCATTTCGGTTTGCAGGAGGCACCCTTTGGCCTGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_20

>merge|NZ_CP050994|20|4074070-4074195|CRISPRCasFinder
ATGTACCTGAACCATTTCGGTTTGCAGGAGGCACCCTTTGGCCTGATCGGCGTTGGCCGTGACGGGGACTGGGAGGGGATATGTACCTGAACCATTTCGGTTTGCAGGAGGCGCCCTTTGGCCTGA

>NZ_CP050994|20|20|4074070-4074195|CRISPRCasFinder
ATGTACCTGAACCATTTCGGTTTGCAGGAGGCACCCTTTGGCCTGA	TCGGCGTTGGCCGTGACGGGGACTGGGAGGGGAT
ATGTACCTGAACCATTTCGGTTTGCAGGAGGCGCCCTTTGGCCTGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_168236237.1\|4061854_4063387_+\|histidine-ammonia-lyase	unknown	unknown	gnl\|CDD\|236484
NZ_CP050994.1\|WP_106887810.1\|4071281_4071929_+\|MSHA-biogenesis-protein-MshJ	unknown	unknown	gnl\|CDD\|309474
NZ_CP050994.1\|WP_168236250.1\|4081519_4082095_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|227302
NZ_CP050994.1\|WP_168236252.1\|4082904_4083324_+\|MSHA-biogenesis-protein-MshP	unknown	unknown	unknown
NZ_CP050994.1\|WP_168236248.1\|4078023_4079244_+\|type-II-secretion-system-F-family-protein	unknown	unknown	gnl\|CDD\|224376
NZ_CP050994.1\|WP_168236238.1\|4063522_4064620_-\|calcium:proton-antiporter	unknown	unknown	gnl\|CDD\|182580
NZ_CP050994.1\|WP_168236247.1\|4075036_4076179_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NZ_CP050994.1\|WP_168236249.1\|4081050_4081533_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|225076
NZ_CP050994.1\|WP_106885194.1\|4079324_4079786_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_168236241.1\|4068808_4069756_-\|1-aminocyclopropane-1-carboxylate-deaminase/D-cysteine-desulfhydrase	unknown	unknown	gnl\|CDD\|225313
NZ_CP050994.1\|WP_139744580.1\|4079862_4080522_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|225076
NZ_CP050994.1\|WP_168236251.1\|4082094_4082865_+\|type-II-secretion-system-protein	unknown	unknown	gnl\|CDD\|225076
NZ_CP050994.1\|WP_168236240.1\|4066828_4068748_+\|RNase-E-specificity-factor-CsrD	unknown	unknown	gnl\|CDD\|236833
NZ_CP050994.1\|WP_168236243.1\|4070688_4071282_+\|PilN-domain-containing-protein	unknown	unknown	gnl\|CDD\|377469
NZ_CP050994.1\|WP_163137281.1\|4080540_4080984_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|225076
NZ_CP050994.1\|WP_168236242.1\|4069825_4070692_+\|MSHA-biogenesis-protein-MshI	unknown	unknown	gnl\|CDD\|227306
NZ_CP050994.1\|WP_168236245.1\|4072306_4073986_+\|pilus-(MSHA-type)-biogenesis-protein-MshL	unknown	unknown	gnl\|CDD\|274176
NZ_CP050994.1\|WP_163148094.1\|4076310_4078020_+\|Flp-pilus-assembly-complex-ATPase-component-TadA	unknown	unknown	gnl\|CDD\|225363
NZ_CP050994.1\|WP_168236239.1\|4064789_4066343_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NZ_CP050994.1\|WP_168236244.1\|4071921_4072236_+\|general-secretion-pathway-protein-GspB	unknown	unknown	gnl\|CDD\|339769

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_168236237.1\|4061854_4063387_+\|histidine-ammonia-lyase	gnl\|CDD\|236484	PRK09367, PRK09367, histidine ammonia-lyase; Provisional.	0
NZ_CP050994.1\|WP_106887810.1\|4071281_4071929_+\|MSHA-biogenesis-protein-MshJ	gnl\|CDD\|309474	pfam04350, PilO, Pilus assembly protein, PilO. PilO proteins are involved in the assembly of pilin. However, the precise function of this family of proteins is not known.	0.00380035
NZ_CP050994.1\|WP_168236250.1\|4081519_4082095_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl\|CDD\|227302	COG4967, PilV, Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion].	6.93404e-06
NZ_CP050994.1\|WP_168236248.1\|4078023_4079244_+\|type-II-secretion-system-F-family-protein	gnl\|CDD\|224376	COG1459, PulF, Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion].	6.22355e-126
NZ_CP050994.1\|WP_168236238.1\|4063522_4064620_-\|calcium:proton-antiporter	gnl\|CDD\|182580	PRK10599, PRK10599, sodium-potassium/proton antiporter ChaA.	2.19269e-99
NZ_CP050994.1\|WP_168236247.1\|4075036_4076179_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	2.24151e-08
NZ_CP050994.1\|WP_168236249.1\|4081050_4081533_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl\|CDD\|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	2.92429e-08
NZ_CP050994.1\|WP_168236241.1\|4068808_4069756_-\|1-aminocyclopropane-1-carboxylate-deaminase/D-cysteine-desulfhydrase	gnl\|CDD\|225313	COG2515, Acd, 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism].	9.13305e-60
NZ_CP050994.1\|WP_139744580.1\|4079862_4080522_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl\|CDD\|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	3.92092e-08
NZ_CP050994.1\|WP_168236251.1\|4082094_4082865_+\|type-II-secretion-system-protein	gnl\|CDD\|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	1.41621e-06
NZ_CP050994.1\|WP_168236240.1\|4066828_4068748_+\|RNase-E-specificity-factor-CsrD	gnl\|CDD\|236833	PRK11059, PRK11059, regulatory protein CsrD; Provisional.	0
NZ_CP050994.1\|WP_168236243.1\|4070688_4071282_+\|PilN-domain-containing-protein	gnl\|CDD\|377469	pfam05137, PilN, Fimbrial assembly protein (PilN).	0.00175381
NZ_CP050994.1\|WP_163137281.1\|4080540_4080984_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl\|CDD\|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	1.5142e-10
NZ_CP050994.1\|WP_168236242.1\|4069825_4070692_+\|MSHA-biogenesis-protein-MshI	gnl\|CDD\|227306	COG4972, PilM, Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion].	4.28997e-05
NZ_CP050994.1\|WP_168236245.1\|4072306_4073986_+\|pilus-(MSHA-type)-biogenesis-protein-MshL	gnl\|CDD\|274176	TIGR02519, related_to_type_II_protein_secretion_protein, pilus (MSHA type) biogenesis protein MshL. Members of this family are predicted secretins, that is, outer membrane pore proteins associated with delivery of proteins from periplasm to the outside of the cell. Related families include GspD of type II secretion (TIGR02517), the YscC/HrcC family from type III secretion (TIGR02516), and the PilQ secretin of type IV pilus formation (TIGR02515). Members of this family are found in gene clusters associated with MSHA (mannose-sensitive hemagglutinin) and related pili, and appear to be the secretin of this pilus system. [Cell envelope, Surface structures].	1.15536e-85
NZ_CP050994.1\|WP_163148094.1\|4076310_4078020_+\|Flp-pilus-assembly-complex-ATPase-component-TadA	gnl\|CDD\|225363	COG2804, PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion].	0
NZ_CP050994.1\|WP_168236239.1\|4064789_4066343_-\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	2.87973e-83
NZ_CP050994.1\|WP_168236244.1\|4071921_4072236_+\|general-secretion-pathway-protein-GspB	gnl\|CDD\|339769	pfam16537, T2SSB, Type II secretion system protein B. This is the B protein from some operons of bacterial secretion systems of type II. The exact function of the B protein is not known, though in the case of Vibrio cholerae there is a fusion protein between proteins A and B that includes an AAA domain, a PG_binding domains well as this domain at the C-terminus. Many of the other species have no A or B domain genes in this operon. The type II secretion pathway is conserved in Gram-negative bacteria that are prevalent in bacterial pathogens of plants (Pseudomonas fluorescens, Erwinia or Xanthomonas species), animals (Aeromonas hydrophila) and humans (Klebsiella oxytoca, Pseudomonas aeruginosa, Vibrio cholerae or Legionella pneumophila). Typical type II secretion systems (T2SSs) are encoded by a set of 12 to 16 gsp (general secretion pathway) genes organized into large operons including the conserved 'core' genes denoted C to O and in some bacterial species, as indicated above, extra gsp genes such as gspAB, gspN or gspS. A different nomenclature is used for Pseudomonas T2SSs, so the B gene is referred to as the P protein.	0.00231542

>NZ_CP050994.1|WP_168236245.1|4072306_4073986_+|pilus-(MSHA-type)-biogenesis-protein-MshL
MKKHHFCLLPLALAVAACTSYQHPEPVQAKDALKQAMKEQTPTAPLTTLPPSVQSELLQLNRPQQPLAVPEKRLRIAAHDVDAVEFFGSLFKGSRYSVAVHPGVAGAISVELKDVTLQEALATVGDMYGFDVQRKGNVFHVYPAGLRTETIPVNYLMMARRGLSRTSVSTGGVTANDNNNNGNNNFDSSGNNNNGNNNLGSSNGDNGSSNNSNGTQIETDSNNDYWSDLRDALQTLIGTGEGRAVITSPQAGLVTVRAYPKELKAVREFLDQSGEHLKRQVVLEARILEVALNEGYEQGVDWSGLSASWDGNKGITGGGSLLDSPIASTPNQIFRALGGGAGFTISDGNFNVAVSLLKTQGDVNTLSSPRVTATNNQKAVIKVGTDEYFVTNASTTTTTSGNSAPIVTPNVELTPFFSGIALDVTPQIDEAGRVLLHIHPSVIDTEEQSKTINVGTADPLVLPLAKSSIRESDTVVQANNGDIIVIGGPMKTDKQEIVSKVPLLGDIPWVGEAFTNRRESTKKVELVILLKPTVVEKDTWQKELQRSSELLDKWYPPKG
>NZ_CP050994.1|WP_168236244.1|4071921_4072236_+|general-secretion-pathway-protein-GspB
MAKWLTLLCCLLGPLAQAEVLQDPTAPLAGSGVAASPSKGAGLPRLQSVILGNGPALAVLNGQSYRVGQRIDGFLLVGISADAVVLEKAGKRQTLTLFGSKIRM
>NZ_CP050994.1|WP_106887810.1|4071281_4071929_+|MSHA-biogenesis-protein-MshJ
MEMTAQWRAWAQRVAALSLRERVLILLTGTILLGAAGIYGWLDAADTRLSQERQALTAAQRDLEILTLENQGKQARLGRDPNAQVRQQLAGVEASLGRLDAELKAQTVDLIPAHEMPAVLEALLSRSANLHMLALTSLKPEPLMAGEQKANLFKHGIRLQLEGGYFDVYQYLKALEALPRHFYWKGFDYRVVEHPKAAVEMEIYTLSTSKEFIRG
>NZ_CP050994.1|WP_168236243.1|4070688_4071282_+|PilN-domain-containing-protein
MKHHINLYGAEFRPRRLWASLNQMALVWGGCLLLLIAATFFYGWQQRGVDRELAQVRALLDVQRSEASRLDAALARHQADGQLQQQLVNKREELAAKQALIRQLGSLSLQKSQGYASVMADLARLRDARLSLQRIEISDGHINLSGVAERSQDVPAWVNRFKQTPSLAGKQFGELTLSRDKAGQLAFQLSGIARETP
>NZ_CP050994.1|WP_168236242.1|4069825_4070692_+|MSHA-biogenesis-protein-MshI
MKSLFRRSPPSHQVGLLLASDRILLACVEPVPIFTSRAINGPNDWPKAMGELFAQHGLAKSKVRVALAASLYQQIQIDKPAVPDAEMAGALPWAIKDFVNEPVLQLAMDYVDLPTPPAGRPRINVICVPKSRVQQLADAVNGVATLEAIVSDELAMTALYEADQTVRMLLWQPKGQELQLLVFYRGGLCFSRPLRGFVSLTGAHEPDQGMLDGLTLEIQRSLDYLAGQLKLPEPGQMQLAIGSPFIGTLVRHLEQAFGFPVSAMANKAVLAGVEYLSAYGAALGRSEG
>NZ_CP050994.1|WP_168236241.1|4068808_4069756_-|1-aminocyclopropane-1-carboxylate-deaminase/D-cysteine-desulfhydrase
MTNDALTAKRASLGDAILAPAQLPSPLHPIHHPLLDAQGVRLWCKRDDLIHPTLSGNKWRKLKYHLQQAQAQGKTHLLSFGGAYSNHIHALAAAGLRSGLRTTGIIRGEADTVSNATLSAAKGWGMDLVFVDRQSYRRRQDPDWLAQFEAPDTLIVPEGGSSPLAIPGVAELVAEVPFSPDLWVLPCASGGTLAGLIAGKRERERILAIAVLKGGAFLHDEVCRLNPAAATTSGWRIAQDHHDGGYARFSPALWQWVQAFSAHTGLPLEPIYSGKAMWGLFRELAAGRIPRGSQVVFIHTGGLQGLAGLREQGRL
>NZ_CP050994.1|WP_168236240.1|4066828_4068748_+|RNase-E-specificity-factor-CsrD
MKLTTQLVSFITLCVISAMAVVMLGGVFSFRQMGMELQQNRVDSLVEIIDKQLGVTDDQQALARWLPSLLRASHVVELEIRQDSQRVYWFRDVQQQTDESLLIPYSKAIPNQAGMQAEFKLDRPFKEFEYSMQAMFGISLGVFIVVFGLWYSIRWLRQQLRGAELLAERAQLILDGKLTKLAHDPADEWPLSASQALTHLLAELADARKERSRFDNFIRSNAFVDKTTGIGNRLFFDNRLENAIMEASVISGGVLLIELAGLEELDPELNGRPSQDLLMEASASIGTFVRKHSGALQARYAGQVFAVLLPNMSESEMVDGASQLLKSLQRLHWPESVNLETAVYLGAVCYQAEDSLLKVQEEAELALKSARLQGHSGWFLYEKSLDEEASNKGTVRWRTLINRRIEEQGISFYLQSVQQERDQVVLQQELLIRLHDEQGRELQAGVFMPMAEKAGLLLPLDRLVVTQTLRLLRQRPESSCPVSLSLSAQNLLNREFQRELFFELFQLPRSINEGLILQLSESQVTRHYEALKRPLRALRMLGCRLAIDHAGQDVVSTQYIKEFEIHFLKLHPSLVREIHLRQVNQMAVRSLVGGCANTQARVIAVGVESGDEWKMLRHLGVHAGQGPWFAEPERLVMPA
>NZ_CP050994.1|WP_168236239.1|4064789_4066343_-|EAL-domain-containing-protein
MHPSGRYPLRRASPFWISLLLLCLPVLASLPLSQLLGNPLAHQLLQQKKAQIEAALAERHEALDQSIRSQLSRFAFDCGPADMALLRDPRFYSRHIRLQGLKLASGGGCSSLGEDFPLATVELPPYPEQEQFGLAATQPRFNTEQEVVAYYRKGGNVAYWVLNNSWSHDQLQSPCTGCFYLEFGQQSTGKVTTFFPRGDKSIKQEPGNQSLSFFDPDPQIRQTLWAGKALEEYAKRQARHYGLLYGGALGLLLVAAYWVLRNYRRSLKGLLQAALVRREFVPFYQPIVDSRSKKVVGFEALLRWQRGRELVPPGTFIDYAEEQGLILPMTEQLLERVIADLPWLEPTQWVSVNIVAAHLEQPNLRPLLQRHDWPSPARLTFELTERKPITDIKAAMGEIAQLQEKGYHFKLDDFGTGYGGFAYLQRLGIRQIKIDKMFVDTIGTDDLKRTLLDSIIAFGHESNMEMIAEGVETLEQVDYLHRHGVHLIQGYVYAKPMALTKLKIWLLAWRQSQPGGQ
>NZ_CP050994.1|WP_168236238.1|4063522_4064620_-|calcium:proton-antiporter
MKSFIRQEIALPVGLLTLLFFKTLGSDLLTEATPLAVYLPVSLALLAIVTWAIFSVVRHSDALAIKLGEPFGTLILTLSVISLEVVMISSVMLTGDPNPTMARDTMFAVVMLVTNGLVGFTLLFGGWRYHTQNFNLDGVKSYLVAIIPLALLCLVLPNFTRGGTLGSMSSPMSWMLIIISVLLYGVFLLIQTRSHSHFFVDSDHEDHEEHHGILRSNVYHTLLLLAYLVLVILLAKTLAIPINYGVHVLEAPAALGGFIVACIVLAPEAVGAIKAAFNNQLQRAMNLYFGSVLATIALTVPSVLFIGSLLGQEVRLGLSAADMVLLITTLMVCKVTFSSGRTNVLHGATHLVLFVVYLFLMFEHE
>NZ_CP050994.1|WP_168236237.1|4061854_4063387_+|histidine-ammonia-lyase
MFELNLQPGKLCLATLRRVSREPVHVSLDSSALPGIHASAAVVTKVIEQNRVVYGINTGFGLLANTRIPVEQLDELQRSIVLSHAAGIGEYMDDATVRLMMVLKVNSLARGFSGIRLTVLEALMTLINAEVYPVVPKKGSVGASGDLAPLAHMSCLLIGEGKARHKGELIDAATALKIAGLEPIALAPKEGLALLNGTQASTAFALEGLFHAEDLFAGAITIGAMSVEAALGSRRPFDARIHEVRGQRGQIDAAACYRHLLVDGSEIGMSHHNCEKVQDPYSLRCQPQVMGACLAQIRHAAEVLVCEANAVSDNPLVFAEDEEILSGGNFHAEPVAFAADNLALAIAEIGSLSERRMALLIDSRMSGLPAFLVNNGGVNSGFMIAQVASAALASENKTLAHPASVDSLPTSANQEDHVSMATFAGRRLADMAENTRGILAVELLAAAQGLDFRAPLRSTELIELAKGRLREEVSFYDKDRYFSPDIEAAAALLGRASYNDLIPAGILPSL
>NZ_CP050994.1|WP_168236247.1|4075036_4076179_+|tetratricopeptide-repeat-protein
MSVINQMLRDLEQRQGGTEAAVYVAPVRRQGWWMLVLTLLCGLAIGILGWRTWIYWQQSQRVQIPTAMADVLQSYDAASHTKAASSSVTAPAVMPLSAALALSTSEAATVADTPAAGTREPVALADLPAADDEPPAPQLEPEERVDDEVVPSDEELQPDLQAELAAEQEAIAAAPPRKPGVLKIETVDLSEPELAALAERKATTAMAKGQMREAQDNYYQVLAHDPHNQGAREQLAGLLYGEGRLTEAGQVLEEGLRLAPQQADFRLLLARVAIGEGDRQKALDWLTGYQPDLAANLDYYATWAGLAQELGQPAQASELYVKLLRQQPDQGRWWLGLGVAEDGQGHRQRALDAYGNAQLHGNLGEASTRWLEQRIAELTP
>NZ_CP050994.1|WP_163148094.1|4076310_4078020_+|Flp-pilus-assembly-complex-ATPase-component-TadA
MAQPRLKMRLGDLLVQEQIISDDQLQLALQQQRQTGRKLGTTLIDLGFISEVQLLQFLARQLDVPFFDLNNLTIDASAVTLLPEVQARRYRALAVNLSDDKVTVAMSDPADLSALDAIAALLSPREMVLAVAREGQLLEYFDRLYRRTREIESFAEQLHEEYQDAGFELGSSNLGAGDEGEATVAKLLRSLFEDAVQVGASDIHIEPDEKVLRIRQRIDGVLHENILNEVRIAQALVLRLKLVAGLDISEKRLPQDGRFAMKVRGRDVDVRMSTMPVQYGESVVMRLLDQSSGILSLAETGMPPAILSRFRRQLKRPHGMILVTGPTGSGKTTTLYGALSELNQASHKIITVEDPVEYRLPRVNQVQVNPKIGLTFSQVLRSTLRQDPDILLVGEMRDNETVEIGLRGAITGHLVLTTLHTNDAVTSALRLIDMGAPGYLVASALRAVVAQRLVRRVCEHCACETAPDQGQATWLTMLSGEAPGQHLYRKGRGCQSCNFTGYAGRIGVYELLELDQPMMDALRRNDAEGFARAAREHEHYRPLALTALDYAREGITSVDEVLRLAEDLG
>NZ_CP050994.1|WP_168236248.1|4078023_4079244_+|type-II-secretion-system-F-family-protein
MGSFNYKGRDSQGQAVSGMVEAASELAAAEQLMRRGVMPTELKAGKAKSAGIDWSLLLEGSVKLEELVVFSRQMYALTRAGIPILRAIAGLEESAHSKPLKRALHTLGEDLGNGRPLSSSMQAHPKVFNSLFVAIIHVGENTGQLEEAFLQLANYFDLELETRKRIKTAMRYPSFVMIAIGIAMVILNIMVIPVFAGMFAKFGVELPLATRILLATSHFFVHYWWLLLAILAGMVFGWRRWVASPQGKLTWHRWQLRLPIVGTIIERSLLARFARSFSMMLKAGVPLNTALTLVADAVDNAYMAGQIRDMRAGIERGESLLRTAGASGLFTPLVMQMIAVGEETGQVDELLHEAAEYYEREVDYDLKSLTARIEPILIGIVAVMVLVLALGIFTPMWDMMRAVRGQ
>NZ_CP050994.1|WP_106885194.1|4079324_4079786_+|hypothetical-protein
MSRQSEQDERWLGGYRRMVACLLLLVILATLALSYRSHREEALAVSLSLLGEQFAERAQRLHGRWLDERRPEVLHAEGVAWQFDGRGWPLAVLPLQSPSANCRQLWLTLIGPEDPGLPSWQALASQHGDGCEFGWEGHWLFYRFSDGRVLAKP
>NZ_CP050994.1|WP_139744580.1|4079862_4080522_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MAAKRVSAGQGPGQMAGFSLIELVIVIVILGILAVTALPRFLDVTDEAKKASVEGVSGGFATAVSLVRAQWEAEGRAKQDSLNTVLYDGSRFYLTTPTDSQVSNGELSPGYPMDTAASGAPDVDPANLTAARCLNIWEGLLQNPPKATANFDEVRGSGNDLKFYATVSNNGLDSVCRYYLVNSLSKGSDGRYQDPQGSTDAYMSFSYRPASGQVTTNIN
>NZ_CP050994.1|WP_163137281.1|4080540_4080984_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MKKQAGFTLIELVIVIIILGILAVTAAPKFLNLQDDARLAAANGVKASLQSSSQLVYSKAAILGVEGSSSGAVSVAGATVKTNYGYPVNTDAGKTVALDGWSGAMSGSIATFKPSNEPNSKCAVTYDNAITAAGGVPSIAVSTDCGK
>NZ_CP050994.1|WP_168236249.1|4081050_4081533_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MTTAKGFTLIELVIVILLLGILAAFAVPKWLGKGGFETHTLRDELVTRLRLVQTMNMHEGEARCTQLVLEQSRFAHLTQTGNCAPGSIIDNWSADERSRGRVVTASGDISLPQGSFSFDKRSGRPLSPSTCVNGCNLVVSSGQESARLRIEPEGYIHALP
>NZ_CP050994.1|WP_168236250.1|4081519_4082095_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MPSLKARRGFTLIEFVVGIVLLAIALTGILGLLINQAPQGVDPVQQVRGAQLAQRILGEVLQKSFDEHSDHNGGRFRCGERVGTPAVTYPACTPVADYGPDGGETRPYEFNDVDDFDTAGNWVDANQFTQTNAEGVSDEEYRHYQVRIAVTPDTLFGSSGLGAESIGKRVALTVRLPDQSELAFTLYRGNY
>NZ_CP050994.1|WP_168236251.1|4082094_4082865_+|type-II-secretion-system-protein
MRATKGFTLVELVMVILLLGVMATFSSQFIGIGTQIYGDASRREQLMSDARFALERLNRELRDAVPGSVRIEDAAGIPLDQGACLRFWPIATASRYLGSAASGGLTIVEPEVLPREEDEAIIYPLADPALNLEQGCLHGNCVARVISVGSPVSGALPLTVDGAFTKESPGQRIYFARQQVRYCVMNAALTRASAAIGTDFHGSTPALMAEHVRPAPYYFYREPAAFSQSEVGLRMELEQRGERVLFNHKLETLNVP
>NZ_CP050994.1|WP_168236252.1|4082904_4083324_+|MSHA-biogenesis-protein-MshP
MVALFVIVIMALLAAGMGRFLVDSGEKNTVEVRGVRALMAAQSGLEIALYQLFPNRSGAELPAACTRVAASHTFDKDPGLSGCRVSVSCNEIQASQGGETSTTYRLTSLGTCGTEAAGANPGFAVSRTLVAEAFDGVTP

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Crispr_ID: NZ_CP050994_21

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_21

4168713-4168811

Orphan

Consensus_repeat	Method
TGAAGGGCAAGGGGTTCGGCGACTAGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_21

>merge|NZ_CP050994|21|4168713-4168811|CRISPRCasFinder
TGAAGGGCAAGGGGTTCGGCGACTAGCCGACCCTCTGCCCCTGCGCTCTGCTCGCGGGGCCCTGCCCAAGTTGAAGGGCAAGGGGGTCGGCGACTAGCC

>NZ_CP050994|21|21|4168713-4168811|CRISPRCasFinder
TGAAGGGCAAGGGGTTCGGCGACTAGCC	GACCCTCTGCCCCTGCGCTCTGCTCGCGGGGCCCTGCCCAAGT
TGAAGGGCAAGGGGGTCGGCGACTAGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_163135810.1\|4175322_4176561_-\|DUF3391-domain-containing-protein	unknown	unknown	gnl\|CDD\|225116
NZ_CP050994.1\|WP_168236300.1\|4169301_4170072_-\|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|336781
NZ_CP050994.1\|WP_168236302.1\|4173608_4174124_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|183256
NZ_CP050994.1\|WP_162627239.1\|4165697_4166378_+\|DUF484-family-protein	unknown	unknown	gnl\|CDD\|225701
NZ_CP050994.1\|WP_168236605.1\|4171530_4173159_-\|DUF342-domain-containing-protein	unknown	unknown	gnl\|CDD\|377177
NZ_CP050994.1\|WP_106885145.1\|4163024_4163231_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|338858
NZ_CP050994.1\|WP_168236305.1\|4179098_4181063_-\|LTA-synthase-family-protein	unknown	unknown	gnl\|CDD\|224287
NZ_CP050994.1\|WP_106885148.1\|4159356_4161876_+\|class-I-adenylate-cyclase	unknown	unknown	gnl\|CDD\|236522
NZ_CP050994.1\|WP_106885146.1\|4162636_4162951_-\|iron-donor-protein-CyaY	unknown	unknown	gnl\|CDD\|274572
NZ_CP050994.1\|WP_168236304.1\|4177891_4178410_-\|protein-tyrosine-phosphatase	unknown	unknown	gnl\|CDD\|350355
NZ_CP050994.1\|WP_168236296.1\|4158104_4159034_-\|hydroxymethylbilane-synthase	unknown	unknown	gnl\|CDD\|234612
NZ_CP050994.1\|WP_111910712.1\|4176705_4177653_+\|homoserine-O-succinyltransferase	unknown	unknown	gnl\|CDD\|235433
NZ_CP050994.1\|WP_168236297.1\|4161968_4162622_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|334855
NZ_CP050994.1\|WP_025325515.1\|4178570_4179041_+\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_CP050994.1\|WP_168236303.1\|4174131_4175295_-\|competence/damage-inducible-protein-A	unknown	unknown	gnl\|CDD\|179629
NZ_CP050994.1\|WP_042649014.1\|4163251_4164502_+\|diaminopimelate-decarboxylase	unknown	unknown	gnl\|CDD\|273415
NZ_CP050994.1\|WP_168236301.1\|4170437_4171247_-\|sugar-phosphatase	unknown	unknown	gnl\|CDD\|182509
NZ_CP050994.1\|WP_106885144.1\|4164663_4165494_+\|diaminopimelate-epimerase	unknown	unknown	gnl\|CDD\|234768
NZ_CP050994.1\|WP_168236298.1\|4166370_4167327_+\|tyrosine-recombinase-XerC	unknown	unknown	gnl\|CDD\|234698
NZ_CP050994.1\|WP_168236299.1\|4167531_4168242_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|182696

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_163135810.1\|4175322_4176561_-\|DUF3391-domain-containing-protein	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	1.66945e-51
NZ_CP050994.1\|WP_168236300.1\|4169301_4170072_-\|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	gnl\|CDD\|336781	pfam07722, Peptidase_C26, Peptidase C26. These peptidases have gamma-glutamyl hydrolase activity; that is they catalyze the cleavage of the gamma-glutamyl bond in poly-gamma-glutamyl substrates. They are structurally related to pfam00117, but contain extensions in four loops and at the C-terminus.	1.44559e-87
NZ_CP050994.1\|WP_168236302.1\|4173608_4174124_+\|hypothetical-protein	gnl\|CDD\|183256	PRK11648, PRK11648, metal-dependent hydrolase.	9.52588e-66
NZ_CP050994.1\|WP_162627239.1\|4165697_4166378_+\|DUF484-family-protein	gnl\|CDD\|225701	COG3159, COG3159, Uncharacterized protein conserved in bacteria [Function unknown].	8.5592e-38
NZ_CP050994.1\|WP_168236605.1\|4171530_4173159_-\|DUF342-domain-containing-protein	gnl\|CDD\|377177	pfam03961, FapA, Flagellar Assembly Protein A. Members of this family include FapA (flagellar assembly protein A), found in Vibrio vulnificus. The synthesis of flagella allows bacteria to respond to chemotaxis by facilitating motility. Studies examining the role of FapA show that the loss or delocalization of FapA results in a complete failure of the flagellar biosynthesis and motility in response to glucose mediated chemotaxis. The polar localization of FapA is required for flagellar synthesis, and dephosphorylated EIIAGlc (Glucose-permease IIA component) inhibited the polar localization of FapA through direct interaction.	1.17272e-148
NZ_CP050994.1\|WP_106885145.1\|4163024_4163231_+\|hypothetical-protein	gnl\|CDD\|338858	pfam13627, LPAM_2, Prokaryotic lipoprotein-attachment site. In prokaryotes, membrane lipoproteins are synthesized with a precursor signal peptide, which is cleaved by a specific lipoprotein signal peptidase (signal peptidase II). The peptidase recognizes a conserved sequence and cuts upstream of a cysteine residue to which a glyceride-fatty acid lipid is attached.	0.000215164
NZ_CP050994.1\|WP_168236305.1\|4179098_4181063_-\|LTA-synthase-family-protein	gnl\|CDD\|224287	COG1368, MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane].	9.51651e-94
NZ_CP050994.1\|WP_106885148.1\|4159356_4161876_+\|class-I-adenylate-cyclase	gnl\|CDD\|236522	PRK09450, cyaA, class I adenylate cyclase.	0
NZ_CP050994.1\|WP_106885146.1\|4162636_4162951_-\|iron-donor-protein-CyaY	gnl\|CDD\|274572	TIGR03421, FeS_CyaY, iron donor protein CyaY. Members of this protein family are the iron-sulfur cluster (FeS) metabolism protein CyaY, a homolog of eukaryotic frataxin. ISC is one of several bacterial systems for FeS assembly; we find by Partial Phylogenetic Profiling vs. the ISC system that CyaY most like work with the ISC system for FeS cluster biosynthesis. A study of of cyaY mutants in Salmonella enterica bears this out. Although the trusted cutoff is set low enough to include eukaryotic frataxin sequences, a narrower, exception-type model (TIGR03421) identifies identifies members of that specific set. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	2.46932e-54
NZ_CP050994.1\|WP_168236304.1\|4177891_4178410_-\|protein-tyrosine-phosphatase	gnl\|CDD\|350355	cd14505, CDKN3-like, cyclin-dependent kinase inhibitor 3 and similar proteins. This family is composed of eukaryotic cyclin-dependent kinase inhibitor 3 (CDKN3) and related archaeal and bacterial proteins. CDKN3 is also known as kinase-associated phosphatase (KAP), CDK2-associated dual-specificity phosphatase, cyclin-dependent kinase interactor 1 (CDI1), or cyclin-dependent kinase-interacting protein 2 (CIP2). It has been characterized as dual-specificity phosphatase, which function as a protein-serine/threonine phosphatase (EC 3.1.3.16) and protein-tyrosine-phosphatase (EC 3.1.3.48). It dephosphorylates CDK2 at a threonine residue in a cyclin-dependent manner, resulting in the inhibition of G1/S cell cycle progression. It also interacts with CDK1 and controls progression through mitosis by dephosphorylating CDC2. CDKN3 may also function as a tumor suppressor; its loss of function was found in a variety of cancers including glioblastoma and hepatocellular carcinoma. However, it has also been found over-expressed in many cancers such as breast, cervical, lung and prostate cancers, and may also have an oncogenic function.	1.22407e-42
NZ_CP050994.1\|WP_168236296.1\|4158104_4159034_-\|hydroxymethylbilane-synthase	gnl\|CDD\|234612	PRK00072, hemC, porphobilinogen deaminase; Reviewed.	0
NZ_CP050994.1\|WP_111910712.1\|4176705_4177653_+\|homoserine-O-succinyltransferase	gnl\|CDD\|235433	PRK05368, PRK05368, homoserine O-succinyltransferase; Provisional.	0
NZ_CP050994.1\|WP_168236297.1\|4161968_4162622_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|334855	pfam02230, Abhydrolase_2, Phospholipase/Carboxylesterase. This family consists of both phospholipases and carboxylesterases with broad substrate specificity, and is structurally related to alpha/beta hydrolases pfam00561.	5.59808e-37
NZ_CP050994.1\|WP_025325515.1\|4178570_4179041_+\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	4.77279e-36
NZ_CP050994.1\|WP_168236303.1\|4174131_4175295_-\|competence/damage-inducible-protein-A	gnl\|CDD\|179629	PRK03673, PRK03673, nicotinamide mononucleotide deamidase-related protein YfaY.	8.27308e-90
NZ_CP050994.1\|WP_042649014.1\|4163251_4164502_+\|diaminopimelate-decarboxylase	gnl\|CDD\|273415	TIGR01048, Diaminopimelate_decarboxylase, diaminopimelate decarboxylase. This family consists of diaminopimelate decarboxylase, an enzyme which catalyzes the conversion of diaminopimelic acid into lysine during the last step of lysine biosynthesis. [Amino acid biosynthesis, Aspartate family].	0
NZ_CP050994.1\|WP_168236301.1\|4170437_4171247_-\|sugar-phosphatase	gnl\|CDD\|182509	PRK10513, PRK10513, sugar phosphate phosphatase; Provisional.	3.72526e-106
NZ_CP050994.1\|WP_106885144.1\|4164663_4165494_+\|diaminopimelate-epimerase	gnl\|CDD\|234768	PRK00450, dapF, diaminopimelate epimerase; Provisional.	2.38516e-154
NZ_CP050994.1\|WP_168236298.1\|4166370_4167327_+\|tyrosine-recombinase-XerC	gnl\|CDD\|234698	PRK00236, xerC, site-specific tyrosine recombinase XerC; Reviewed.	1.94793e-156
NZ_CP050994.1\|WP_168236299.1\|4167531_4168242_+\|HAD-IA-family-hydrolase	gnl\|CDD\|182696	PRK10748, PRK10748, 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB.	4.86614e-59

>NZ_CP050994.1|WP_168236299.1|4167531_4168242_+|HAD-IA-family-hydrolase
MQFYRRWQPVAAISFDLDDTLYDNGPAIARAEQWMLSHLRSEYLATAMLDKPRWLELKRNLLLARPELGQDVSLARQLGIREAMVQGGMAASRAEQEAERVFAAFLAERSKIEVSQGTHQLLAKLAERYPLAVITNGNLDLVQAGLADYFTLVCKAGAGARMKPAPDMFVQVQQALGLAPGQILHVGDHPETDVLGARLHGFKAAWLNERRLPWQSLQLLPDVELATLDELAGLLL
>NZ_CP050994.1|WP_168236298.1|4166370_4167327_+|tyrosine-recombinase-XerC
MAKAPLPAADPLPASLAGELTAFIEYLRVERQLSPHTRSNYQAHLEAMAAELVRLGVDDWARLEASQVRSLVTRMHKAGLAPRSLATKVSALRSFCDWQVRQGRLPANPARGIVTPKQGRPLPKNLDVDEMYQLLNITDEQDPLAVRDRAIMELMYSSGLRLAELVGLNLADVKLDERQLRVTGKGSRERVLPMGRMAVEWLQKWLKVRPLLAGGEGEALFVSRRRQRLSARSVQERLDGWGNKQALNAHVHPHKLRHSFATHMLESSGDLRAVQELLGHADLSTTQIYTHLDFQHLAKVYDSAHPRAKRDPATPEDE
>NZ_CP050994.1|WP_162627239.1|4165697_4166378_+|DUF484-family-protein
MSELKRQESLMDEATVLEYLARYPEFFQRHGAMLDRIRIPHEHKGTISLVERQLDRQRERIEQLEQEITELMGIASENERIFRVYADLYGELYGCQTLFELSAVMGKAFVQRLRLTGLRLWLSPKKFQLTGPEQRFLADGKQLDQLLGQRLPGTDYYFGRLNQSEKQALFGSDVLVNSVALMRLGDLGVLAFASSDPSHFTPHNDTLLLGQLGRLLQLRLPELVRG
>NZ_CP050994.1|WP_106885144.1|4164663_4165494_+|diaminopimelate-epimerase
MLIEFSKMHGLGNDFMVVDGVTQKVFFSNDVIKKLADRHFGIGFDQLLLVEPPYDPELDFHYRIFNADGSEVEQCGNGARCFARFVRLKGLINRDRIAVSTARGRITLQLEGENQVTVNMGVPQFEPGKIPFRAQKAEKTYLLRAQDHTVMCGAVSMGNPHCVIEVPSVADAPVETLGPIMERHERFPERVNVGFMEMVSASEIKLRVFERGVGETLACGTGACAAVVLGISQGKLRERVTVTLPGGKLTIAWKGPGQPVYMTGPAEHVFDGQIEL
>NZ_CP050994.1|WP_042649014.1|4163251_4164502_+|diaminopimelate-decarboxylase
MDHFNYDADGQLQAEQLPLQQLADQYGTPLYVYSRATLERHWHAFDQAAGDIPHLICYAVKANSNLALLNLLARLGSGFDIVSGGELSRVLAAGGDPAKVVFSGVAKSEAEMRLALEKEILCFNLESEAELERLNRVAGSMGKKARVSVRVNPDIDAGTHPYISTGLKQNKFGIPIEQAPAIYRKAAAMAHIEIKGVDCHIGSQLTELNPFMEAADKLLKLIDELAAEGIHIHHLDVGGGLGVNYGAEQPPHPTEYAEALKQKLAGRDLTLLFEPGRAIVANAGVLLTRVEFLKPGETRNFALIDAGMNDLLRPSLYGAWMNIIEVDSRTTHEKALYDVVGPVCETGDFLGKERTLAIAEGSLLAVRSAGAYGFTMSSNYNTRPRAAEVLVDGDQAHLIREREQLADLWRGEHLLP
>NZ_CP050994.1|WP_106885145.1|4163024_4163231_+|hypothetical-protein
MITQFTKCLFAASLSFGLAACGLTGPLYMPPAEQPASTEQAPAQPKTESTPQAASPATATPASEAAPQ
>NZ_CP050994.1|WP_106885146.1|4162636_4162951_-|iron-donor-protein-CyaY
MKDHEYHALTDAFFQYVEDVIDEGYPDIDCERAGGVLTLSFENKTKVIINKQEPLHQIWVATRENGFHFELRGDSWIDNRFGDELKALLTRACTTQAGEPVQFP
>NZ_CP050994.1|WP_168236297.1|4161968_4162622_-|alpha/beta-fold-hydrolase
MMDLHPQGARHAVIWLHGLGDSGAGLAPLVDALALPATLPVRHLLPDAPERPITINMGYKMRGWYDIKSFDDPADRAVESHVRESADRIAALLDRLVAEGFAPGNIVLAGFSQGGVIASFTALRYQAKLAGLLCMSTYLAAPERLIEEMSEAARALPICYMHGIYDDVVSLSMGWDAKNRLEAAGLSLEWHEYPMRHEICRPQLADIRHWLLARLGA
>NZ_CP050994.1|WP_106885148.1|4159356_4161876_+|class-I-adenylate-cyclase
MLVKLDTLVARYDELNRLKTQRALDLMSRYGQQVFQLLPVMLHFNHPLLPGYVAGDVPHGIWSFVANEAQQAFIQDLCQNANCQGGLSTHDKSIQGLYSMGSTSSIGQCCHSDLDIWVCHVAGLSQERLALLEQKCQHLSLWAEQRGVDLNFFLIPEDKFRQRNDAQMQGESCGSAQHLLLLDEFYRSAMHIAGKRLLWYLVPAEYDDHYDDYVNGLFAHGKLSQDDWLDLGGFDRIPAEEYFGSALWQLYKGIDSPYKAVLKSVLMEAYSHEYPNTRLLSVTSRDWFQHNEGMHYRLDNYCLMLDKVTNYLKSIGDMQRLDLVRRCFYLKVCDGLSHPKEEHSPDWRREQMAQLVAYWGWSPERLHHLDHRQEWKVEDVKVAYAELLEALMQSYRNLIQFARRNNISESINPEDIGILSRKLYAAFESLPGKVQRINLKIAPDLGEPDLSLVQVPHGRLNRAGWYLYKHSLEPADIIGRAPLEYNGYISKLVAWAYFNGLLTPQSRVHLFNQGSDLHIDNLHQFCRDLSGTFPVKYPRATNLALSRPCEIHQLSIFLNLETDPSSHWVGQVIEFDANAADVFSFGRNQECLVGSVDLVYRNSWSEIRTLHFQGEEAVVDALTTILGKMHQDAAAPEMIEVFCYSQHFRSLVRTRFQQLVAECIELRLARDKQQLVKTLALGREKYGIFFERRGVSVKKLENAIDFYRHISHNKLDHLPLRLDKTHSQHLPGIVDTYASEGLVQFFFDTRDAGTNIYILDEANRVEIYQHFAGNKDELVQGVNRFYTSGHERFSDAGQFSNFNLPQYYEIVQMGDKLEVIPYRSQNPQRDNPGAAREVG
>NZ_CP050994.1|WP_168236296.1|4158104_4159034_-|hydroxymethylbilane-synthase
MAARTLRIATRKSPLALWQANFVKDRLEALYPDLRVELVPMSTQGDKILDTPLAKVGGKGLFVKELETAMLEGRADIAVHSMKDVPVEFPEGLGLHTICEREDPRDAFVSNRFKQIDELPQGAVVGTSSLRRQCQLRAARPDLVIRDLRGNVNTRLAKLDAGEYDAIILAAAGLKRLEMAHRITAFIEPEQSLPANGQGAVGIECRQDDHELHALLAPLEHAETRIRVLTERAMNRALQGGCQVPIGAYALVQGDEVWLRGLVGSPDGTQVIRDEIRGPQADGEALGHALAQRLLAAGADLILAEVYRA
>NZ_CP050994.1|WP_168236300.1|4169301_4170072_-|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein
MPNPSSHSKPVVLMTMGAQARSGHAYQVMTHKYITPLVELSGCVPLLVPTCCGTADLEQYLDLVDGVYLSGAGSNIDPALYGQENLTPEKAQDRDRDLFDIALVRATLDRGLPLLGICRGMQEINVALGGDIHQKVYCEPGYADHREDADDPVEEQYGHSHQVSLVPGSWFADLMGEAQIPVNSLHGQGIRRLGEGLAPLAHAEDGLIEAIHAPALSPFLLAVQWHPEWKAKENPHSIKLFSAFGDACRQYRQRAG
>NZ_CP050994.1|WP_168236301.1|4170437_4171247_-|sugar-phosphatase
MYKLIALDMDGTLLNPHGQITPRTHAAIAAARAQGVTVVLTSGRPLEGMTPYLAELGLTGQDDYVICYNGALVQQVADQRILRSQLLTGSDASAIAHLASELGVNVHGFSVRQGLISPRISTYTEHESQLIKMPINLVDFATLTADEQIMKVMMIDPEPQLSRAIAQLPAELYERYTVVRSSPYFLEFMNKRSNKGTGVAALAEHLGLTASQVIAVGDAGNDRHMIEYAGLGVAMGNATDEIKTLAQHTTARNDEDGVARVIEQFILNA
>NZ_CP050994.1|WP_168236605.1|4171530_4173159_-|DUF342-domain-containing-protein
MTYVCLRITPGLTEPVQEQHVLALLRLSNCRRYQPLDEGIRQAVALLNTLLTQPDAPSHPPVPIAQRQDARLLVLVDKDQMSASAQITADWGGNPLTLAQLQEAVAASPIKQGVSERLLAAAIKAASEAAPGARLNPVIALGKAARHGQDTRLERLVETAAERILKPQEVDHGKVDMRDLGTLLTVKAGAPLMRRHPATQGIDGFTVTGQVLPARSGKESAMTAGEGTCFSPEDPDLLLATRAGLPCQERAGMRVDEVLSVKQVDIRHGHVMFEGSLLVTGDVMPGMRIKTSGDVVIGGFVEGGYIESGGTITVRNGIIGRKLEGDQYLCHLNAGGEIHASYAQYARLEADGDIHIQSQLSHSYCRSGQDIRVGDSAMRKGHLIGGINIANRLIMAPVLGASAANRTRLQILGGYFSHKEQEQALRQRKQACREQLDKLQDLILRLLQLPGDKRNPETLKKIKELRTRQLDESKSLDEQLAEAQRELQALMANMDIIATQRLFPGVEVEMAHHHNRVDIEHGPIHFAIREDQLQLTPYESQH
>NZ_CP050994.1|WP_168236302.1|4173608_4174124_+|hypothetical-protein
MTAQGHLLFSVTCALLAHKVELTPALAEGSLWHIVPIALASALLPDLDHPQSLLGRQLPWISGPLSRLFGHRGFTHSLLAVGLGIWGLAQFQAPGPLSGVMKGALIVGYLSHLLGDWLTPAGIPLFWPWRRRFRLPGLPLKSGGGYEKAFCLLTLALAGYWVHGSAGLGAF
>NZ_CP050994.1|WP_168236303.1|4174131_4175295_-|competence/damage-inducible-protein-A
MRIEIISTGDEIVTGLVVDTNAAWLSALLLEQGWQVRRRLTVGDNLADLKAALQESASRAEVVLVCGGLGPTADDLTAQAAAEAFDQPLTLFPDWLATMAERYASRGRTMAQSNSKQAWLPRGCEILDNPVGTACGFLVSHPASHGQSRLFFTPGVPFEFKQMVREQILPRLKALAGEETDTELRRFYTFGISESALSDKLDAAPWPAGIELGYRSSMPLIELKLIGHGASAADMAAAEARLLGEISPWLVGRGNEDPAQQILALLGERPLWLQEGESRGALLAMCHPHPVLEASFSHNLPSELDHLTCSGREPSLTIGSTGHDGVPLLLCADGQRIGQRVKLSHPDPESGRRILAFAALDMLRRHLQGLPVLADYLTLTRTASRID
>NZ_CP050994.1|WP_163135810.1|4175322_4176561_-|DUF3391-domain-containing-protein
MTGIKISVDRLQVGNYVSLPLGWREHPFLFSSFKLKSEEEIELIRRLGLKLVTIIPDKSDAPPKPLDQVQPAPDGTDDLVGRQQEMQQEKARRIEQLQRYRRDLQQCEKHFQQSLAQVRNLMGKIQSRPLNAINEAQELINAMTEQLLSVDEMVLHLVSDSADGNSLQFHSLNVSVLSMLLARECKLPAEAIRQVGMGALFHDIGKLKIPSQILRKTSPLTKPEQNLMAQHPRYGLELLSLASGFPEPAKRIVQYHHEYLDGSGPQGLRGDQLDPLTQIVSLINEYDNLCHLQAKVPYSALGNLYKQRKAQFNTDHLGMLIRLMGIYPPGSVVQLSNGQVGLVMSVNASRLLYPAVLVYDPRIPRQEAAIIDLEQAELTIAKVIHPKRLPPAVFEYLNPRTRISYYFEHNKP
>NZ_CP050994.1|WP_111910712.1|4176705_4177653_+|homoserine-O-succinyltransferase
MPIKIPDQLPAAEVLGQENIFVMTESRAVTQNIRPLRVLILNLMPKKIETEIQLMRMLSNSPLQVDVDLLRIDDRESKNTPQAHLENFYHDFEQVRGNNYDGMIITGAPLGLVEFEEVVYWPRIVEIIEWSHQHVTSTLFLCWAVQAALKALYGMEKQTHGEKLSGVYRHHRLDEHEPLLRGFDDEFVAPHSRYAAFDGDLIRAHTDLQIFAESEEAGVYLAATKDCRQVFVTGHPEYDALTLDGEYQRDLAAGLTPVIPVNYYPDDNPGQTPRATWRSHGHLLFSNWLNYYVYQLTSYRLEDIGKVFTYEQPKG
>NZ_CP050994.1|WP_168236304.1|4177891_4178410_-|protein-tyrosine-phosphatase
MLSAHPFWSLEVPRLDGQLLLTPCPGNQQVAMPLALAQLQLAGAGGVLTLMTKDELAARGAGSLGSLVRARGMAWFHLPIADDEAPDEAFEQAWPPVLPQLLALLSEGRHLAIHCHGGSGRTGLVAALLLLTLGQPQPEAMAAIRARRPGAFTLACHRHWLDTRGRRLAGAD
>NZ_CP050994.1|WP_025325515.1|4178570_4179041_+|Lrp/AsnC-family-transcriptional-regulator
MRNLDQLDLDILAHLFRDAGMTNKDLAALVGVAPSTCLERVRKLQQDGVLKGAHCEVDYQALGGHIQAMVSLQLARHSRQIIDAFRDAILALPEVISLFHMGGKDDFLVHLCVADTEHLRNFVFDHFTSREEVVHLETSLVFEHRFSRSLPCFTHP
>NZ_CP050994.1|WP_168236305.1|4179098_4181063_-|LTA-synthase-family-protein
MTKIRDWLGPFWPIAIFSVIALIALSASRAGLGLWQQERVDAVAGWSQLLLQGIRVDLATLCWLWGVPAVFTLLLAGPHALGRAWLQLIRVWLTLGLWLMLFLEISTPAFVTEYGVRPNRLYIEYLIYPKEVLAMLWAGRKGELLLALVFSLLTLGGGWWLSGRLMRHLSFPRWHLRPAFALLILAIGFLGARSSLGHRALNPAMVAFASDPLVNALTVNSAYSLFFAIKQMSNEESAGEFYGELPRERILELVREESGRPGQDFNSEILPSQTFNEASHGGKPKNLVILLQESLGAQFVGSLGGLPLTPNIDALSREGWAFEQLYATGTRSVRGIEAVLTGFTPTPAQAVVKLGKSQTNFFTIADLLKQRGYDTSFIYGGESHFDNMRSFFLGNGFTTIVEQKDFKNSVFEGSWGASDEDLMAKANDTFEALHKQGKPFFSLVFSSSNHDPFEFPDDRISLYEQPRATRNNAAKYADYAVGEFFRKAKASDYWKDTLFLVIADHDSRVGGASLVPIPRFHIPGVIVGEGIAPKQDRRIVSQIDMAPTLLSLMGISADYPMLGKDLTRMPADWPGRAIMQYDKNFALMRGKDVVILQPERAAEGFVYDDASETLTPAPQPDAMKGAALGLVLWGNLAYQQGLYQTAPDDRLALN

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Crispr_ID: NZ_CP050994_22

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_22

4355766-4355883

Orphan

Consensus_repeat	Method
GTTGTGAACGGGATGCCACCGGCTAACCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_22

>merge|NZ_CP050994|22|4355766-4355883|CRISPRCasFinder
GTTGTGAACGGGATGCCACCGGCTAACCAGGGGTCAGGGAGTCAGCGTGAAGTGGTCGACAGTCTGCTGTGCCAATGCCAGCAGCAAGCGTTGTGAACGGGATGCCGCCGGCTAACCA

>NZ_CP050994|22|22|4355766-4355883|CRISPRCasFinder
GTTGTGAACGGGATGCCACCGGCTAACCA	GGGGTCAGGGAGTCAGCGTGAAGTGGTCGACAGTCTGCTGTGCCAATGCCAGCAGCAAGC
GTTGTGAACGGGATGCCGCCGGCTAACCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_025325677.1\|4351524_4352061_+\|glutathione-peroxidase	unknown	unknown	gnl\|CDD\|238207
NZ_CP050994.1\|WP_025325672.1\|4346338_4346713_-\|YacL-family-protein	unknown	unknown	gnl\|CDD\|377595
NZ_CP050994.1\|WP_168236383.1\|4349565_4350699_+\|glycerate-kinase	unknown	unknown	gnl\|CDD\|376844
NZ_CP050994.1\|WP_106885004.1\|4363286_4364027_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|182980
NZ_CP050994.1\|WP_005308670.1\|4362615_4363086_-\|transcriptional-regulator-ArgR	unknown	unknown	gnl\|CDD\|179922
NZ_CP050994.1\|WP_168236388.1\|4358655_4360281_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224099
NZ_CP050994.1\|WP_111912149.1\|4355887_4356382_-\|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|234860
NZ_CP050994.1\|WP_005332293.1\|4345991_4346288_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_005332325.1\|4357027_4357366_+\|P-II-family-nitrogen-regulator	unknown	unknown	gnl\|CDD\|223424
NZ_CP050994.1\|WP_168236385.1\|4356409_4356826_-\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|181730
NZ_CP050994.1\|WP_168236387.1\|4357608_4358616_+\|Fe(3+)-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270260
NZ_CP050994.1\|WP_168236390.1\|4361631_4362537_+\|Dyp-type-peroxidase	unknown	unknown	gnl\|CDD\|273607
NZ_CP050994.1\|WP_163154448.1\|4348293_4349556_+\|GntP-family-permease	unknown	unknown	gnl\|CDD\|225330
NZ_CP050994.1\|WP_168236386.1\|4357451_4357676_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_111913744.1\|4354537_4355391_+\|IS5-family-transposase	unknown	unknown	gnl\|CDD\|379129
NZ_CP050994.1\|WP_111912147.1\|4353261_4354458_+\|NupC/NupG-family-nucleoside-CNT-transporter	unknown	unknown	gnl\|CDD\|224883
NZ_CP050994.1\|WP_041204171.1\|4352143_4353079_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NZ_CP050994.1\|WP_168236382.1\|4347058_4348174_+\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226355
NZ_CP050994.1\|WP_168236384.1\|4350901_4351465_+\|NnrU-family-protein	unknown	unknown	gnl\|CDD\|377807
NZ_CP050994.1\|WP_168236389.1\|4360515_4361550_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_025325677.1\|4351524_4352061_+\|glutathione-peroxidase	gnl\|CDD\|238207	cd00340, GSH_Peroxidase, Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per subunit, which is involved in catalysis. Different isoenzymes are known in mammals,which are involved in protection against reactive oxygen species, redox regulation of many metabolic processes, peroxinitrite scavenging, and modulation of inflammatory processes.	5.06534e-60
NZ_CP050994.1\|WP_025325672.1\|4346338_4346713_-\|YacL-family-protein	gnl\|CDD\|377595	pfam06062, UPF0231, Uncharacterized protein family (UPF0231). Family of uncharacterized Proteobacteria proteins.	8.34732e-51
NZ_CP050994.1\|WP_168236383.1\|4349565_4350699_+\|glycerate-kinase	gnl\|CDD\|376844	pfam02595, Gly_kinase, Glycerate kinase family. This is family of Glycerate kinases.	0
NZ_CP050994.1\|WP_106885004.1\|4363286_4364027_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|182980	PRK11124, artP, arginine transporter ATP-binding subunit; Provisional.	1.20736e-132
NZ_CP050994.1\|WP_005308670.1\|4362615_4363086_-\|transcriptional-regulator-ArgR	gnl\|CDD\|179922	PRK05066, PRK05066, transcriptional regulator ArgR.	6.54499e-113
NZ_CP050994.1\|WP_168236388.1\|4358655_4360281_+\|iron-ABC-transporter-permease	gnl\|CDD\|224099	COG1178, ThiP, ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism].	3.39755e-109
NZ_CP050994.1\|WP_111912149.1\|4355887_4356382_-\|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl\|CDD\|234860	PRK00901, PRK00901, methylated-DNA--protein-cysteine methyltransferase; Provisional.	3.17771e-62
NZ_CP050994.1\|WP_168236382.1\|4347058_4348174_+\|XRE-family-transcriptional-regulator	gnl\|CDD\|226355	COG3835, CdaR, Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms].	1.50178e-147
NZ_CP050994.1\|WP_005332325.1\|4357027_4357366_+\|P-II-family-nitrogen-regulator	gnl\|CDD\|223424	COG0347, GlnK, Nitrogen regulatory protein PII [Amino acid transport and metabolism].	1.42647e-58
NZ_CP050994.1\|WP_168236387.1\|4357608_4358616_+\|Fe(3+)-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270260	cd13542, PBP2_FutA1_ilke, Substrate binding domain of ferric iron-binding protein, a member of the type 2 periplasmic binding fold superfamily. FutA1 is the periplasmic component of an ABC-type iron transporter and serves as the primary receptor in Synerchosystis species. The periplasmic iron binding protein plays an essential role in the iron uptake pathway of Gram-negative pathogenic bacteria and is critical for survival of these pathogens within the host. After binding iron with high affinity, FutA1 interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The iron- and thiamine-binding proteins belong to the PBPI2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.09378e-157
NZ_CP050994.1\|WP_168236390.1\|4361631_4362537_+\|Dyp-type-peroxidase	gnl\|CDD\|273607	TIGR01413, Probable_deferrochelatase/peroxidase_EfeN, Dyp-type peroxidase family. A defined member of this superfamily is Dyp, a dye-decolorizing peroxidase that lacks a typical heme-binding region. A distinct, uncharacterized branch (TIGR01412) of this superfamily has a typical twin-arginine dependent signal sequence characteristic of exported proteins with bound redox cofactors.	3.49464e-79
NZ_CP050994.1\|WP_163154448.1\|4348293_4349556_+\|GntP-family-permease	gnl\|CDD\|225330	COG2610, GntT, H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism].	4.99718e-65
NZ_CP050994.1\|WP_168236389.1\|4360515_4361550_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	1.14094e-125
NZ_CP050994.1\|WP_111913744.1\|4354537_4355391_+\|IS5-family-transposase	gnl\|CDD\|379129	pfam13340, DUF4096, Putative transposase of IS4/5 family (DUF4096).	1.28892e-26
NZ_CP050994.1\|WP_111912147.1\|4353261_4354458_+\|NupC/NupG-family-nucleoside-CNT-transporter	gnl\|CDD\|224883	COG1972, NupC, Nucleoside permease [Nucleotide transport and metabolism].	8.57294e-161
NZ_CP050994.1\|WP_041204171.1\|4352143_4353079_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.82278e-76
NZ_CP050994.1\|WP_168236385.1\|4356409_4356826_-\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|181730	PRK09256, PRK09256, aminoacyl-tRNA hydrolase.	1.79473e-55
NZ_CP050994.1\|WP_168236384.1\|4350901_4351465_+\|NnrU-family-protein	gnl\|CDD\|377807	pfam07298, NnrU, NnrU protein. This family consists of several plant and bacterial NnrU proteins. NnrU is thought to be involved in the reduction of nitric oxide. The exact function of NnrU is unclear. It is thought however that NnrU and perhaps NnrT are required for expression of both nirK and nor.	6.3458e-41

>NZ_CP050994.1|WP_111913744.1|4354537_4355391_+|IS5-family-transposase
MSRRYQLTDVQWGLIEPLFPHHRISGRPTREPRQVLDGILWILHTGAPWRDLPERFGPWSSVYNTFRRWQSTGRIDAILEALQLYLNEEGLIDFDLWCIDGSNVRASKDAAGARKKNTPVNQALGRSRGGFGSKIHLVTDGNGLPLGFCLSPGQSAEIRYATSALAMARIPTSSGRYRTRPAHLAADKAYSSRAFRAELRRRRIKAVIPQRRDQQRHHKGRPLVLDKARYRRRNVVERCFGWLKKFRRFSTRYEKLAVSFSAFIKLAFCLRYLRELLVDRKPAF
>NZ_CP050994.1|WP_111912147.1|4353261_4354458_+|NupC/NupG-family-nucleoside-CNT-transporter
MIALLGILSILALAALCSDNRRRIPLRTVGLALCLQVLFAALVLWLPAGQSVLNGVSESVSSVIGYGQEGIAFLFGDLAKFKLGFIFAFNVLPVIIFFSAVIAILYHIGIMPRVIALLGGGLQKLLGTGRAESLSATANIFVGMVEAPLVVKPYLSKMSDSQFFAVMSCGLASVAGGTLVGYASIGVELKYLIAAAFMSAPAGLAMAKILVPPGADEVDHHQDVEIPRATNVIEAAADGAMSGLNIAVAVGATLLAFVGVIAMLNGLLGWAGDLVGLDLSFQIILGWLFAPVSWLIGVPWDQAQAAGALIGTKIVINEFVAFIALVQDQTLDESSKAIVTFALCGFANISSMAILIGGLGAMVPERKSFIARYGMRAILAGVLANLMSASLAGLFLAL
>NZ_CP050994.1|WP_041204171.1|4352143_4353079_+|LysR-family-transcriptional-regulator
MVIFDALVREQGISAAARRLGVSKSHISKQLAQLETELGAQLVQRTTRRFSLTELGQEYARHCRALVAVALEADSMVAERRGKVSGVLHLGVGQSFGRLHVIPRLKAFQARYPDLELEVSLFDHRTNLVDEGLDLWITTYEDKPEGLVGQRLADIGFVLVASPDYLLSHGTPLHPRDLARHNCITYQSRERRYHEWSFRQGKERQTVQVAGNYRVDLAEAVRDAALAGLGIAYVANYLLDKELQSGQLIPLLPQWRPNQKMAVHAVYARREHLDPKIRLFIDFLKESFGPEPYWAQRLAPWLGGRLSGVEE
>NZ_CP050994.1|WP_025325677.1|4351524_4352061_+|glutathione-peroxidase
MKWFTLLLLLGSGAASAACPDYFNVEMRELNNTQRHNLCQLTEGKVVLVVNTASYCGYSGQFRDLEALYQSYKDKGLMVLGFPSNDFWQEAGNENKTAEVCRRDYGVTFPMFNRVSVRGADAVPLFKGLAAAADGDAPNWNFHKYLVGRDGKLIASYGANQNPADDPLKEQLIQALGR
>NZ_CP050994.1|WP_168236384.1|4350901_4351465_+|NnrU-family-protein
MILLTLGVLLFTLIHLYPCFAAAHRARMCDRLGENRYKGLFSLLVFVAIGCILAGWRSASPMPLYFPPAWGPMLVMAVMPVALILLCAGQGANHLRRWLVHPQLLGTLLWACAHLAVNSEARSLVLFGGLGAWALVSIVWISVRDWHTKPRPAATWQGTGISVGAGLALTALLIFWGHGWLTGIPLH
>NZ_CP050994.1|WP_168236383.1|4349565_4350699_+|glycerate-kinase
MKIVIAPDSFKESLSAMAVADAIEAGFKLVLPDATYVKLPMADGGEGTVQSLVDATGGHILPVEVTAPLGNKVQGFVGLLGDGERAVIEMAAASGIHLVAPEQRNPLLTSSLGTGELILAALEMGVTHLILGIGGSATNDGGAGMIQALGGKLLKADGSPIALGGGALSELTRIDLSGLDPRLTGLTIEVACDVDNPLCGPKGASAVFGPQKGATPEMVAQLDANLAHYADCIEQALGKQVKELPGAGAAGGMGAALVGLLGAELKPGIQIVIEALKLADEVADADLVITGEGRIDSQTIHGKTPIGVARCAKQFGKPVIGIAGCLTDDCGVVHDHGIDAVFAVVNRAMSLPEAIATATTNLQLTARNVAALYLLRR
>NZ_CP050994.1|WP_163154448.1|4348293_4349556_+|GntP-family-permease
MIPVSALGALAALSIAIFLILKKVPPAYGMIVGALAGGLIGGADLTQTVALMIGGAQGITTAVMRILAAGVLAGVLIESGAATTIAETIVRKLGETRALLALALATLILTAVGVFVDVAVITVAPIALAIARRADLSKAAILLAMIGGGKAGNVMSPNPNAIAASDAFHLPLTSVMAAGIIPGLFGLVMAYWLAKRLNKRGSKVAADEVVNFDGGKLPGFFAAISAPLVAILLLALRPIAGIVVDPLIALPLGGLVGALMMGKFSKVNQFAVSGLARMAPVAIMLLGTGTLAGIIANSGLKDVLISGLTASGLPSYLLAPISGALMSLATASTTAGTVVASNVFSSTLIELGISSLAGAAMIHAGATVFDHMPHGSFFHATGGSVHMGVGERLKLIPYETAVGLTIATVSTLMFGVFGLA
>NZ_CP050994.1|WP_168236382.1|4347058_4348174_+|XRE-family-transcriptional-regulator
MQLNDTLARQIVSRAMKILSFSVNVMDERGLIIASGNPERLHQRHEGAVLALTENRVVEISEATAQQLKGVRPGINLPIAYQGELLGVIGISGDPEEVRAYAELVRMTAELILEQAALTEQLQWDKRHKEELVLQLIRGEGRADQLQQAARFLDLDLAQPRVVAVLALEEADPARLRELVHLLENPERDNLVAINGLDEIVVLKPAQLSDGIWQSAQERSRIKLLLARIPHFKVRIGVGDYFAGTGGLARSYQTARDTLRRGMSQAPRKQVYFFEDYRLPVLLGSLADSWQADQLRAPLLKLAKEDAKGTLQKTLRQYFLQDCDLHPCAETLFIHPNTLRYRLTRIEQITGLSFNKLDDKFLLYLGLNLDG
>NZ_CP050994.1|WP_025325672.1|4346338_4346713_-|YacL-family-protein
MDYEFRRDPFGGYRARFSMGHEAIGQWLIDEVGKDEETLDELFSIIDQLSNRTRTEYRRHGGDYSLLLTPEEAEVKANVLNIELDEDLDDLAYYDDEQLAMCGLEDFAQVLGSWRAFIRNEDMG
>NZ_CP050994.1|WP_005332293.1|4345991_4346288_-|hypothetical-protein
MSIYDFDDELPEDEEQESSQKAAVPAKKKGKQVMNTQVNLSPRDASRLNGLHVEAITTLDDVSLPKNVIFKAGLIALGELEATKRADIIARVIAESGR
>NZ_CP050994.1|WP_111912149.1|4355887_4356382_-|methylated-DNA--[protein]-cysteine-S-methyltransferase
MRYSFCDSAQGPLLVAIDQDGLRFVEFVRGEQPVTPRAQWQRDDVALAPYLEQFEAYFAGRLRRFTLPLAARGTPFQQSVWRALCDIPYGETVSYLEIAQAIGNPKAVRAVGAANGRNPLSIIVPCHRVIGSSGALTGYAGGIPIKRWLLALEQQTVDHFTLTP
>NZ_CP050994.1|WP_168236385.1|4356409_4356826_-|aminoacyl-tRNA-hydrolase
MLVISNSVIIPWHELQFQTMRAQGAGGQHVNKTDSAVWLRFDYRDSPSLPDLYKEGLEKLSDSRVHDGFIQIRVETHRSQDMNRKEAMSRLTDLLKKAAWRPKARHATKPTRSSQRKRVDAKKRKGEIKSARGKPGME
>NZ_CP050994.1|WP_005332325.1|4357027_4357366_+|P-II-family-nitrogen-regulator
MKLITAIIKPFKLDDVREAIANLGVEGLTVSEVKGFGRQKGHTELYRGAEYQVDFLPKVKLEIATADENVEGVIEAICKAAYTGKIGDGKIFVYDLLQAVRIRTGESDDEAL
>NZ_CP050994.1|WP_168236386.1|4357451_4357676_+|hypothetical-protein
MERLGGIPSGLFVLATIKYVALPLQTALILSSRFMQNANENSYHYMHKQGMDDENEDVGAGVLLADRPVGLCRR
>NZ_CP050994.1|WP_168236387.1|4357608_4358616_+|Fe(3+)-ABC-transporter-substrate-binding-protein
MKMKMLALVFSSLIAQSAFAAAEVNVYSNRQDELIKPIIQQFEKETGIKVNVVFAKEGLNERLEREGKLSPADLMLTVDISRLTDLVDKDLVQPVDSKTLQENIPSIYRDPDNKWFALTTRVRAIYSSKDRLGKLDTIRYEDLVKPEFKGKICTRSGKHEYNVALVSSMIAHHGMADTKTWLEGIKANLARKPQGNDRDQVKAIKDGICDVSLGNSYYLGAMLKDPAQKSWAEAVYINFPNQADRGAHVNVSGVAMTKYAKNKEAAQKLMEFLSGDTAQHMYADVNAEYPVKAGVEPSAMVKSWGSFKSDPMPVSDYAKHRKDALQLLDEVKFDL
>NZ_CP050994.1|WP_168236388.1|4358655_4360281_+|iron-ABC-transporter-permease
MKNFGWIAGSWATALLLGLPVLALIFSAFSADGDLFRHLADTVLLDYLGNTSGLVLGVVLLSLLFGVPTAWLVAMCQVPGRRALQWALMLPMAMPSYIVAYVYTDLLDYSGPLQAGLRSLFDWQSPADYWFPAIRSLGGAAWVLALVLFPYVYLLARASFLEQSVSLIHSSRLLGCTPWQSFRRLSLPLARPAIMVGASLVAMETLADFATVHFFAINTLTTAIYDTWLGYGSLATAARLSCLMLLAVVLLIALGRRSRQRQQVFQKSMGHEQPLRYPLKGASRLLAGLWCWGLVLAGFGLPFAILLDYGVRYFELSWTPEFVRFAGNSLLISALTALLAMAIALLLGFFRRLDGGTRSLLPLRIAATGYAMPGTVLAIGVLVPLTALDFGLNDLAEWLGMQGPGLLLTGTLTAIVFGYLVRFVAIAIGSVESSMGKISPSLDMAARSLGQGTGGMLRRVHLPLVRRGLFAGAMLVFIESMKELPAALLLRPFNFETLATHVYQFVSDEMLERGALGAIVIVLVGLVPLIWVNRSLDSPGH
>NZ_CP050994.1|WP_168236389.1|4360515_4361550_+|ABC-transporter-ATP-binding-protein
MSCLQVEKVSCRYNGQNVLEQLSLTVADNEIVCLLGASGCGKTTLLKAVAGLLPLAEGSIRLGETLLDGPGVTVSPERRHIGMIFQDYALFPHLTVAENIGFGLTRVPRDSRQQQIDEALTLVNLQGLGDRYPHQLSGGQQQRVAIARALVCKPKLMLLDEPFSNIDTQVRMKLILEIRALLKRQGIGAIFVSHSKEEAFAFADRLALFRAGHIEQVGQPEQLYRRPENRFVAEFLGGVNYLAAEVVDSHCVQTALGVICGHEPHGRAPGERLQLMLRPQQLALAAAADGDLLVREQQFLGHHCRVLVECAGQVLEASIGEPLEGERARVTVAPHALVLFEQMP
>NZ_CP050994.1|WP_168236390.1|4361631_4362537_+|Dyp-type-peroxidase
MKAQAGICAEPNLHALYLMFNRTGDGAELAARLAKLPVLWDAVSADFPDAGFSGLVAVGAEGWDAIYPAARPPQFRGFMAQSANGQEAPNTPFDLFVQLRADRVDVLHHAGQRVMALLAGLVELAEEVRGFRNLDCRDLTGFVDGTENPQDEHRAEVALLEGGEFAGGSYVHVQRWVHAMSDWEKLALKEQEDIIGRTKADNIEYESADKPLTSHIKRVNLKTPKGESMEILRQSMPWGTMTEQGLYFISCCRTPQHFNAMLASMYKGEGSHFDHLLRFTRAVTGAAFFAPSIDFLVAQGK
>NZ_CP050994.1|WP_005308670.1|4362615_4363086_-|transcriptional-regulator-ArgR
MKHNDKQEKLAKAFKALLKEERFGSQAEIVTALQEMGFENINQSKVSRMLSRFGAVRTRNAKMEMVYCLPVELGVPTTSSPLKNLVLDVDHNGALVVIHTSPGAAQLIARLLDSLGKAEGILGTIAGDDTIFITPTSDTDIEELYLSALELFEQTP
>NZ_CP050994.1|WP_106885004.1|4363286_4364027_+|ATP-binding-cassette-domain-containing-protein
MGIELIGIEKSWHKVPVLQQVSFRTAPGETLVLLGPSGAGKSSLLRMMNLLDTPDAGVLRIADSEFSFPSSLSAAEFNRQAQALRRKVGMVFQQYNLWPHLTVMENLIEAPIKVLGMSREAAIEKGAYLLAQLQLADKRDAWPARLSGGQQQRVAIARTLMMDPQVLLFDEPTAALDPEITKEVAEIIRTLSQTGITQVVVTHEVEFARKVASQVIYLEKGRIIESGTAAIFQSPQTSRFAEFLMH

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Crispr_ID: NZ_CP050994_23

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_23

4518828-4518924

Orphan

Consensus_repeat	Method
GTCGGCTGGCCCGGCTGTGGCAGATAGCAGTGCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_23

>merge|NZ_CP050994|23|4518828-4518924|CRISPRCasFinder
GTCGGCTGGCCCGGCTGTGGCAGATAGCAGTGCCCCGCCAGCCAGTGCACTATGGGGATTAGGTCGGCTGGCCCGGCTGTGGCAGATAGCAGCGCCC

>NZ_CP050994|23|23|4518828-4518924|CRISPRCasFinder
GTCGGCTGGCCCGGCTGTGGCAGATAGCAGTGCCC	CGCCAGCCAGTGCACTATGGGGATTAG
GTCGGCTGGCCCGGCTGTGGCAGATAGCAGCGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_168236465.1\|4523079_4523703_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|225222
NZ_CP050994.1\|WP_005324594.1\|4521901_4522219_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225653
NZ_CP050994.1\|WP_106884903.1\|4526211_4526775_-\|DUF2799-domain-containing-protein	unknown	unknown	gnl\|CDD\|378521
NZ_CP050994.1\|WP_168236462.1\|4517553_4518693_-\|chromate-efflux-transporter	unknown	unknown	gnl\|CDD\|273350
NZ_CP050994.1\|WP_025325819.1\|4522293_4522770_-\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_CP050994.1\|WP_168236459.1\|4512632_4514810_+\|1,4-alpha-glucan-branching-protein-GlgB	unknown	unknown	gnl\|CDD\|235445
NZ_CP050994.1\|WP_168236457.1\|4506882_4507956_+\|quinolinate-synthase-NadA	unknown	unknown	gnl\|CDD\|236489
NZ_CP050994.1\|WP_168236463.1\|4519866_4520871_-\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176190
NZ_CP050994.1\|WP_168236456.1\|4504544_4505351_+\|tol-pal-system-protein-YbgF	unknown	unknown	gnl\|CDD\|182745
NZ_CP050994.1\|WP_168236458.1\|4508044_4508911_-\|D-hexose-6-phosphate-mutarotase	unknown	unknown	gnl\|CDD\|185697
NZ_CP050994.1\|WP_005331552.1\|4503861_4504386_+\|peptidoglycan-associated-lipoprotein-Pal	unknown	unknown	gnl\|CDD\|182744
NZ_CP050994.1\|WP_005324617.1\|4526973_4527813_+\|isopenicillin-N-synthase-family-oxygenase	unknown	unknown	gnl\|CDD\|226022
NZ_CP050994.1\|WP_168236467.1\|4525352_4526174_+\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|182523
NZ_CP050994.1\|WP_168236461.1\|4517090_4517483_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	unknown	unknown	gnl\|CDD\|376583
NZ_CP050994.1\|WP_168236464.1\|4521526_4521757_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_168236460.1\|4514809_4516951_+\|glycogen-debranching-protein-GlgX	unknown	unknown	gnl\|CDD\|131155
NZ_CP050994.1\|WP_162627388.1\|4521070_4521496_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP050994.1\|WP_163149201.1\|4510360_4512550_+\|4-alpha-glucanotransferase	unknown	unknown	gnl\|CDD\|236831
NZ_CP050994.1\|WP_168236466.1\|4523870_4525109_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340888
NZ_CP050994.1\|WP_033129683.1\|4509019_4510015_-\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|185323

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_168236465.1\|4523079_4523703_-\|transcriptional-regulator	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	8.28711e-56
NZ_CP050994.1\|WP_005324594.1\|4521901_4522219_+\|hypothetical-protein	gnl\|CDD\|225653	COG3111, COG3111, Periplasmic protein with OB-fold [Function unknown].	0.000215846
NZ_CP050994.1\|WP_106884903.1\|4526211_4526775_-\|DUF2799-domain-containing-protein	gnl\|CDD\|378521	pfam10973, DUF2799, Protein of unknown function (DUF2799). Some members in this family of proteins are annotated as yfiL which has no known function.	1.11133e-24
NZ_CP050994.1\|WP_168236462.1\|4517553_4518693_-\|chromate-efflux-transporter	gnl\|CDD\|273350	TIGR00937, Chromate_transport_protein, chromate transporter, chromate ion transporter (CHR) family. Members of this family probably act as chromate transporters, and are found in Pseudomonas aeruginosa, Alcaligenes eutrophus, Vibrio cholerae, Bacillus subtilis, Ochrobactrum tritici, cyanobacteria and archaea. The protein reduces chromate accumulation and is essential for chromate resistance. [Transport and binding proteins, Anions].	2.03407e-66
NZ_CP050994.1\|WP_025325819.1\|4522293_4522770_-\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	4.14903e-47
NZ_CP050994.1\|WP_168236459.1\|4512632_4514810_+\|1,4-alpha-glucan-branching-protein-GlgB	gnl\|CDD\|235445	PRK05402, PRK05402, 1,4-alpha-glucan branching protein GlgB.	0
NZ_CP050994.1\|WP_168236457.1\|4506882_4507956_+\|quinolinate-synthase-NadA	gnl\|CDD\|236489	PRK09375, PRK09375, quinolinate synthase NadA.	0
NZ_CP050994.1\|WP_168236463.1\|4519866_4520871_-\|NADP-dependent-oxidoreductase	gnl\|CDD\|176190	cd05288, PGDH, Prostaglandin dehydrogenases. Prostaglandins and related eicosanoids are metabolized by the oxidation of the 15(S)-hydroxyl group of the NAD+-dependent (type I 15-PGDH) 15-prostaglandin dehydrogenase (15-PGDH) followed by reduction by NADPH/NADH-dependent (type II 15-PGDH) delta-13 15-prostaglandin reductase (13-PGR) to 15-keto-13,14,-dihydroprostaglandins. 13-PGR is a bifunctional enzyme, since it also has leukotriene B(4) 12-hydroxydehydrogenase activity. These 15-PGDH and related enzymes are members of the medium chain dehydrogenase/reductase family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES.	8.03261e-166
NZ_CP050994.1\|WP_168236456.1\|4504544_4505351_+\|tol-pal-system-protein-YbgF	gnl\|CDD\|182745	PRK10803, PRK10803, tol-pal system protein YbgF; Provisional.	6.76939e-66
NZ_CP050994.1\|WP_168236458.1\|4508044_4508911_-\|D-hexose-6-phosphate-mutarotase	gnl\|CDD\|185697	cd09020, D-hex-6-P-epi_like, D-hexose-6-phosphate epimerase-like. D-Hexose-6-phosphate epimerase Ymr099c from Saccharomyces cerevisiae belongs to the large superfamily of aldose-1-epimerases. Its active site is very similar to the catalytic site of galactose mutarotase, the best studied member of the superfamily. It also contains the conserved glutamate and histidine residues that have been shown in galactose mutarotase to be critical for catalysis, the glutamate serving as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen. In addition Ymr099c contains 2 conserved arginine residues which are involved in phosphate binding, and exhibits hexose-6-phosphate mutarotase activity on glucose-6-P, galactose-6-P and mannose-6-P.	3.72404e-115
NZ_CP050994.1\|WP_005331552.1\|4503861_4504386_+\|peptidoglycan-associated-lipoprotein-Pal	gnl\|CDD\|182744	PRK10802, PRK10802, peptidoglycan-associated lipoprotein Pal.	6.18448e-77
NZ_CP050994.1\|WP_005324617.1\|4526973_4527813_+\|isopenicillin-N-synthase-family-oxygenase	gnl\|CDD\|226022	COG3491, PcbC, Isopenicillin N synthase and related dioxygenases [General function prediction only].	1.02692e-36
NZ_CP050994.1\|WP_168236461.1\|4517090_4517483_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	gnl\|CDD\|376583	pfam01641, SelR, SelR domain. Methionine sulfoxide reduction is an important process, by which cells regulate biological processes and cope with oxidative stress. MsrA, a protein involved in the reduction of methionine sulfoxides in proteins, has been known for four decades and has been extensively characterized with respect to structure and function. However, recent studies revealed that MsrA is only specific for methionine-S-sulfoxides. Because oxidized methionines occur in a mixture of R and S isomers in vivo, it was unclear how stereo-specific MsrA could be responsible for the reduction of all protein methionine sulfoxides. It appears that a second methionine sulfoxide reductase, SelR, evolved that is specific for methionine-R-sulfoxides, the activity that is different but complementary to that of MsrA. Thus, these proteins, working together, could reduce both stereoisomers of methionine sulfoxide. This domain is found both in SelR proteins and fused with the peptide methionine sulfoxide reductase enzymatic domain pfam01625. The domain has two conserved cysteine and histidines. The domain binds both selenium and zinc. The final cysteine is found to be replaced by the rare amino acid selenocysteine in some members of the family. This family has methionine-R-sulfoxide reductase activity.	7.56371e-71
NZ_CP050994.1\|WP_168236467.1\|4525352_4526174_+\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|182523	PRK10530, PRK10530, pyridoxal phosphate (PLP) phosphatase; Provisional.	2.4164e-81
NZ_CP050994.1\|WP_168236460.1\|4514809_4516951_+\|glycogen-debranching-protein-GlgX	gnl\|CDD\|131155	TIGR02100, Glycogen_operon_protein_GlgX_homolog, glycogen debranching enzyme GlgX. This family consists of the GlgX protein from the E. coli glycogen operon and probable equivalogs from other prokaryotic species. GlgX is not required for glycogen biosynthesis, but instead acts as a debranching enzyme for glycogen catabolism. This model distinguishes GlgX from pullanases and other related proteins that also operate on alpha-1,6-glycosidic linkages. In the wide band between the trusted and noise cutoffs are functionally similar enzymes, mostly from plants, that act similarly but usually are termed isoamylase. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NZ_CP050994.1\|WP_162627388.1\|4521070_4521496_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	5.63339e-21
NZ_CP050994.1\|WP_163149201.1\|4510360_4512550_+\|4-alpha-glucanotransferase	gnl\|CDD\|236831	PRK11052, malQ, 4-alpha-glucanotransferase; Provisional.	0
NZ_CP050994.1\|WP_168236466.1\|4523870_4525109_+\|MFS-transporter	gnl\|CDD\|340888	cd17330, MFS_SLC46_TetA_like, Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.32369e-40
NZ_CP050994.1\|WP_033129683.1\|4509019_4510015_-\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|185323	PRK15425, gapA, glyceraldehyde-3-phosphate dehydrogenase.	0

>NZ_CP050994.1|WP_168236462.1|4517553_4518693_-|chromate-efflux-transporter
MGQVFLQFLWLGCISFGGPAAHIGYFQRTFVQRLGWLSQAEYAQLLALCQLLPGPASSQLGFAIGRHRAGLGGALAAFIGFTLPSFLLLLAAAIGLGQLTNNLWLDAALHGLKLLALVVVADAVLTMSRQFCKTVLQQGVMVATAAALWWQPGLLTQLGMLLGAALLCAQRETVGASPATPQARRVPHWPTLLLFALLFAGLPLLTQGPASQLVADFYRAGSLVFGGGHVVLPLLQESVGHSLSQQQFLTGYGLAQLVPGPMFTLASYLGAQLLPATPLTGALLATLALFLPGFLLLWALGPCWQSWLAHPRLAGAVAGINAAVVGLLLAALYQPVWQSAVLAPADLALAAVAFYLLRVIRLPILALAALLVGASLLLI
>NZ_CP050994.1|WP_168236461.1|4517090_4517483_+|peptide-methionine-(R)-S-oxide-reductase-MsrB
MSGNNPEQWRSKLSAEQFHVCWEKGTGRPYSGALLHNRKSGDYLCVCCKSVLFHADAKFDSGCGWPSFDRAIEGTVTYTEDRSHGMARVEITCSQCGSHLGHVFPDGPTETGQRYCVNSLSLDFEPDTDA
>NZ_CP050994.1|WP_168236460.1|4514809_4516951_+|glycogen-debranching-protein-GlgX
MFVMENGVDYPLGARLDEAGCHFCVWAPQSDKVELCLFDEQEQELVRLALPGRRGQYRFGYVRGVKAGQRYGYRVHGMPQEGMLFDPDKLLIDPYARALSRATRWNDDLYQGDSAAMVAKSVVVDDAFDWQGVGKPGIPPERVVLYETHVKGFTRQHPGVPEALRGTYLGVSYPLMIEHLLSLGVTSVQLMPVAAFMSEPRLEQLGLTNYWGYNPIAFFAPEPRYGAGEAVAEFKTMVRELHRVGLEVILDVVYNHTAESGVDGPMLSLKGFDNAGYYAFETGAHGPDYHRHANVTGCGNSVNLDHPNSLRLVLDALRYWVTEMQVDGFRFDLAVTLAREAGEFDPMSAFFKALLADPVLARVRLIAEPWDIGPFGYRLGQFPSQWLEINDRYRDTVRAFWRGDAGKMGDFATRLAGSRDLFPKNWRSPHTSVNYLCYHDGFTLEDLVSYNQRHNQANGEDNRDGHGNNLSYNHGVEGPTLDPRVNNLRQQQKRNLIATLLLSQGTPHFLAGDEMGRSQLGNNNAYCQDNQISWVNWQLRPEDERLLAFTRQMMALRAESGVFANLQLSDDSWNGTSTSCHSVNWYHPDGHQLTDQDWHAPMGQAFAMDIGMLACGGERWYVLFNASDYDIQFRLPPPGEGLEWIQTIDTATNDGLPFLPDDIKRQVAVGRAHSLKLLERVSLPGVALAKEGVVATPDVAAVLPTGSQFPLAG
>NZ_CP050994.1|WP_168236459.1|4512632_4514810_+|1,4-alpha-glucan-branching-protein-GlgB
MPVERLVAARCADPFSHLGLLANPDGPGLKLTAWLPDALEVRVRDLKSGKIVATLTAADEAGLFETVFTRRKNPFPYQLIASYPDASAESIDPYQFQAAAWEGLAELSFQPENLYHTLGAQLRTVEHLGQQVAGVRFAVYAPSATAVSLIGDFNFWDGRRHPMQRSQCGHWVLFVPGLKTGDRYKFELKDPAGHRLPHKSDPVGFYCEQYPSFASVIHDHEQYQWQDAAWRESQRNDKREQPLSIYELHVGSWKRHPNGDSLNWRELAVELVNYVTEMGYTHIELMPVSEHPFSGSWGYQPVGMFSPTSRYGSVDDFKHFVDACHQAGIGVILDWVPAHFPADAHGLARFDGTPLYEYEDPRRGWHPDWNSYIYDFGRNNVRQFLVASALFWLDKFHIDGLRVDAVASMLYLDYSRNAGEWVPNVDGGNHNYEAISLLKWTNEEVYGKYPHTMTIAEESTAFAGVSRPTFLGGLGFGFKWNMGWMHDTLSYMQKEPIHRRYHHNEMTFSMVYHYDENFILALSHDEVVHGKHSLLYKMPGDEWQQAANLRAYMGFMYGHPGKKLNFMGTEIAQSNEWNHDAQLPWHLLQFPKHGGQQRLIRDLNRLYRHEAALYQADYEQSGFRWLDHNDADNSIFAWLRADKQGANPVVIASNFTPVPRLAYRLGVPEAGRYAVVLNTDSEHYWGSNYDVGLTLVAEPTPWQGMAHSIVLDLPPLATLFIKQES
>NZ_CP050994.1|WP_163149201.1|4510360_4512550_+|4-alpha-glucanotransferase
MTTLIEQLAAAKGIASEYVDAWGHPAQVSEESKAAMLGAMGYRVDDEAALTEQLEQEHRQHWLRPLDPVMVVRSGDPISLEVRLPIEFVNDALHWQIVLEQGALLSGQLTPIEGELVGVAEFEEMECQAYRVALDVQPELGYHQLVLLEEGNDEPLATMRLIVAPKSCYKQAPIANGRKVWGPSVQLYCLRSRHNWGIGDFSDLGQLVEQAAAWGAHFVGLNPIHALYPANPESASPYSPSSRRWLNVAYINVEAVPEFLANERLKADVASPAFQQHLASLRAKENVDYTGVIETKIGMLRQVFDEARLSAERQAAFDAFVAAGGDSLQQQAAFDALQAHFYGKGENAWGWPVWPDAFRDYHNPEVAAWMQEHSQDVNFYLYLQFLADEQLAQADARAKAAGMVMGIYRDLAVGVSEGSTEIWANRDLYCPKASVGAPPDILGPLGQNWGLPPMNPNQLFEAAYQPMVDLFRANMRACGALRIDHVMALLRLWWVPPGASAAKGAYIYYPVNDLLGILALESHRNQCLLIGEDLGTVPEGIDVTLKENGVHSYKVFFFERSKGDGGFISPAHYTEQAMSALTTHDMPTLKGFWHCDDLALGRELGLYPDEEVLKTLYADRHQAKQRILDSLHAHGVISGNISHDVNWVGMNTELNHGLQLHMSRGSCALFSTQLEDWLEMDKPVNVPGTSYEYPNWRRKLSKDLEDIFADEALKALAGKMSQARDEASR
>NZ_CP050994.1|WP_033129683.1|4509019_4510015_-|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MTIKVGINGFGRIGRFVFRLAAERADIEVVGINDLIDVDYMAYMLKYDSTHGRFNGTVEVKDGNLVVNGKTVRVTAERDPANLKWDAIGVDVVAEATGLFLDDATARKHIAAGAKKVVLTGPSKDATPMFVMGVNDSTYAGQDIVSNASCTTNCLAPIAKVLNDTFGIESGLMTTVHATTATQKTVDGPSAKDWRGGRGAAQNIIPSSTGAAKAVGVVIPELNGKLTGMAFRVPTPDVSVVDLTVNLKKAATYAEICAAMKAASEGSMKGVLGYTEDQVVSTDFLGERQTSVFDAKAGIALNDKFVKVVSWYDNEMGYSSKVLDLIAHISK
>NZ_CP050994.1|WP_168236458.1|4508044_4508911_-|D-hexose-6-phosphate-mutarotase
MQPTRTLTAHCTLSHPADGQPLLTINNEHARAEISLFGAHVLRYQRHGEPASLWLSDKAVLDGSKPIRGGIPLCWPWFGPSPARVGSGKPSHGFARTSLWTLDGVSDHGDGTLVHLSLRDTDASRALWPHAFELELDVLVGKELSLVLTTRNTGKTPLTYNAALHTYLQISAPEAVSVTGLGEPYADKLTGQDGQQQGALTLTAAIDRVYQQAEAMVMVKDGDRTTKVVSGNNDSVVVWTPWLEGATAMADMSDDGYRTMLCVEAAITAEAGVVIAPDEEHSFSTVII
>NZ_CP050994.1|WP_168236457.1|4506882_4507956_+|quinolinate-synthase-NadA
MSNALSSVPPVIEMDYPFPVKPAPLTADQKAALIIEIKALLEARQAVLVAHYYTDPEIQALAEATGGFVGDSLEMARFGRDHAAQTLIVAGVRFMGETSKILSPHKRVLMPTLEAECSLDLGCPIDQFSAFCDAHPDHIVVVYANTSAAVKARADWVVTSSIALEIVEHLDSQGHKIIWGPDRHLGAYIEKKTGAQMLRWQGHCIVHDEFKAKALRELKAQNPDAAVLVHPESPASVIELADAVGSTSQLIKAARELPQQKLIVATDRGIFYKMQQACPDKEMVEAPTGGDGATCRSCAHCPWMAMNGLVAIKEALTDGAERHEILVDEELRVKALIPLDRMLNFAAELKLKTQGNA
>NZ_CP050994.1|WP_168236456.1|4504544_4505351_+|tol-pal-system-protein-YbgF
MKSVYKQAVVALAVLVALNAHAAAPVSDLGGDSGGGVVLSGNNGAIVPTGSLEDRVALLERTLNARLRLQAELQQQVDSLQGEVSELRGQLEQQTYQMEQPQERQRQLYQELDKVANSQPAAAAPATPAAGATTPAAAANYSTNQDENQAYDAAVNMVLKEKNYDKAIPAFEGFIKQFPSSSYVPNAHYWLGQLMFNKGDRAGAASQFSTVANKYSKSPKRADALLKLGMLAQLDGKKAEAKTFYEQVIKGYPNTSPAQLAKQSLGKL
>NZ_CP050994.1|WP_005331552.1|4503861_4504386_+|peptidoglycan-associated-lipoprotein-Pal
MQLNKLLKGLAIALPLFTLAACSSSSDSDAAGAESGMTDGMGGVQTGGANGMLSPEEQMRQKFEALQRDNVIYFPYDGYDIQGQYADLLDAHASYLRERPSVKVLIEGHADERGTPEYNIALGERRAKAVAKYLQTLGVQAEQLSIVSYGEEKPLDLSHTEDAFAKNRRAVLVY
>NZ_CP050994.1|WP_168236463.1|4519866_4520871_-|NADP-dependent-oxidoreductase
MTPISHQIQLLRRPTGLPVQSDFILKEVPLPALQEGEVQVANQWLSVDPYMRGRMSEAKSYVPPFPLNGPLDGGAIGTVQASRHPDFKVGDQVSSMLGWRDAFVAKGEQLTRLPATALPSQLFLGALGMPGMTAWAGLHKVARLQAGETLLVSAASGAVGTMAVQLAKRAGARVIGSTGSADKVAYLKTLGADAVINYRETPDLDAELARLAPEGIQVYFENVGGAMLDAALNNMALHGRIVLCGLIEQYNSNGQGSGPRNLSQMIRKRILMQGLLVSDHWQHYGDFLAEAIPAFEAGALQAEETISEGLASMPQAFIGLFEGRNTGKMLVKLG
>NZ_CP050994.1|WP_162627388.1|4521070_4521496_+|MarR-family-transcriptional-regulator
MSELKKQVCFALYSASNAVMRAYRPLLDKLDLTYTQYLVMLSLWARDEVSLKEIGQETGLDAGTLTPIVKRLESKGWLTRTVSSEDERQKCIRLTEAGRQLQQGVRECCLADNLRNQVDLADAELAELKRLCDRVATQLGR
>NZ_CP050994.1|WP_168236464.1|4521526_4521757_+|hypothetical-protein
MKPWLPLLALLLSACVDTSYPRSELQIDDADAWQALCKDGVRVRAISEEGICADHRGLAMWTNKPRAVRMAEEAAK
>NZ_CP050994.1|WP_005324594.1|4521901_4522219_+|hypothetical-protein
MQSSIVGLSILWGLASFGVQGDFIESRDSVAPSWQAESRVEMEGYLIESLGEDRWVFDNGSESLLVSLPEGQWVSEGERLRLSGEPQQEQAGWLLQVQDVSQVGV
>NZ_CP050994.1|WP_025325819.1|4522293_4522770_-|Lrp/AsnC-family-transcriptional-regulator
MLKLDRIDRHILELMQENGRISNLELAELVGLSPSPCSRRVKALEDAGLIDTHVTLLNARQLGLTLTAYIHISMDRHTPERFENFDRAIQDLPEVLECDLITGNDADYQLKVVVRDMEHYQHFLLDKLTHISGVTGVRSSFVLRRIKHKTALPLNHLG
>NZ_CP050994.1|WP_168236465.1|4523079_4523703_-|transcriptional-regulator
MNASTDKILYLLKTHGPQSAAALGEQLQMTSMGARQHLTALEADGWVGFSDEARGRGRPIRLWHLTDQAWQRFPDTHSELTLQLIDDVQQLFGESGLDQLIARREQQMLSRYQARLTQPALADRLTALKELRSREGYMADMSQEEDGSWLWWESHCPICAAARACRGFCRSELALFRQLLAPAGVEREQYLLDGDRRCLYRIRPPQA
>NZ_CP050994.1|WP_168236466.1|4523870_4525109_+|MFS-transporter
MEGIKGQATLWVLVMTVTLAMAGFSLPSPVLAPLMLDPAQGMLTPQASDWSRKLWLGVIMGLYPLFQLLGAPWLGKLSDRHGRKPVLTLCLVGVLAGYVLMALGIAWRSLPLLLLSRVVEGFFNGDIAIVQAMAADMSTTRTKARNFARINIGMNLGWVLGPMIGGYAAVVSGDYSLAAWLAVAMTVGNLLLVLWLLPNRPPVPAEQELASLSTRQLLLQPRLLPYFVLTLLSYGAVQLYFTYFNVWLVERLAWDPVQLAQAAVLVSVPMMLGSWLGEQLARHWRGSSLGIVGHLVMAAGMLMFILPTQWWGLALTFIPAGIGMSLGELATSVAISNRSHASQQGQAMGIYRGLAVGSEILAVVLGSLALLAGTEWPFYLAALCGVICALGFYGLRRRADRRSAVAACAEPG
>NZ_CP050994.1|WP_168236467.1|4525352_4526174_+|Cof-type-HAD-IIB-family-hydrolase
MSRFQAIALDMDGTLLTRDHKISSATRAALAQARAHGIKVLLVTGRHFMTARPFHHELALDTPLICSNGAYLYDPAQGRILAGDPLAVAPLTALLAEVQAQQMGALFHLDGGIGYLGCEEHVGRMRRWSANQPDHLKISLLPAQDLAAWLQRPIWKLELFSQDPIRLHRFVSEVVQGLPFTQDWAAPYAVELVQPGCSKGNRLAQWAASEGIAMEKVVAFGDNNNDISMFEQVGLAVAMGNAAPQIQAHADRVTADHNEDGIALALQRWVLPS
>NZ_CP050994.1|WP_106884903.1|4526211_4526775_-|DUF2799-domain-containing-protein
MSPKILLLTLPLLLAGCSSLSEEECRAMSWYNQGYQDGEQGKTRTATRDYKQTCGEYGLRVDEDEWQRGYAKGLELYCIPELAYSKGREGNEYLGVCPNDTSFLTQFERGRKEFLLEQRLGELQQELERTERTIYQLDQQIRGESDSKQRDYYRAQRERAIRHYEGVRRDYNRIRFPDRVIQFSFGS
>NZ_CP050994.1|WP_005324617.1|4526973_4527813_+|isopenicillin-N-synthase-family-oxygenase
MKVLTVDYRSPDAAERFTESLRTTGFGVLTHHPIPKELVQSIYDNWYRFFMSEQKQDFLFNRETQDGYFPPSVSEVAKGNTQKDIKEYFHLYPWGQMPEELRAQAMEYYRLANDLAAELLSWVEQYTPADIAAHYSCPLSSMIEESQKTLLRVLHYPPFDGTEAPGAIRAAAHEDINLLTILPAASEPGLQVKGSDGEWMDVPCDFGTLIINIGDMLQEASHGYYPSTTHRVINPTGGSVSKSRISLPLFLHPRPDVVLSERHTAHSYLMERLRELGVI

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Crispr_ID: NZ_CP050994_24

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP050994_24

4525258-4525359

Orphan

Consensus_repeat	Method
ACAGTTCTTGGAGGTGATATGAGTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP050994_24

>merge|NZ_CP050994|24|4525258-4525359|CRISPRCasFinder
ACAGTTCTTGGAGGTGATATGAGTCATTATCAAGCCATTGCGCTGGACGCGGGATTGTACGGTGCCGCATTCGTTTCGACATTCTTGGAGGTGATATGAGTC

>NZ_CP050994|24|24|4525258-4525359|CRISPRCasFinder
ACAGTTCTTGGAGGTGATATGAGTC	ATTATCAAGCCATTGCGCTGGACGCGGGATTGTACGGTGCCGCATTCGTTTC
GACATTCTTGGAGGTGATATGAGTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP050994.1\|WP_163137780.1\|4518885_4519326_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240034
NZ_CP050994.1\|WP_106884903.1\|4526211_4526775_-\|DUF2799-domain-containing-protein	unknown	unknown	gnl\|CDD\|378521
NZ_CP050994.1\|WP_168236466.1\|4523870_4525109_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340888
NZ_CP050994.1\|WP_168236471.1\|4535581_4536172_+\|LysE-family-translocator	unknown	unknown	gnl\|CDD\|224199
NZ_CP050994.1\|WP_025325819.1\|4522293_4522770_-\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_CP050994.1\|WP_168236472.1\|4536259_4536952_+\|aspartate/glutamate-racemase-family-protein	unknown	unknown	gnl\|CDD\|224707
NZ_CP050994.1\|WP_168236463.1\|4519866_4520871_-\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176190
NZ_CP050994.1\|WP_168236469.1\|4532898_4533363_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_162627388.1\|4521070_4521496_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP050994.1\|WP_005324594.1\|4521901_4522219_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225653
NZ_CP050994.1\|WP_168236470.1\|4533392_4534766_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP050994.1\|WP_168236473.1\|4537202_4538417_+\|aldose-1-epimerase-family-protein	unknown	unknown	gnl\|CDD\|379620
NZ_CP050994.1\|WP_168236474.1\|4538492_4540283_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|223953
NZ_CP050994.1\|WP_168236461.1\|4517090_4517483_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	unknown	unknown	gnl\|CDD\|376583
NZ_CP050994.1\|WP_168236464.1\|4521526_4521757_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP050994.1\|WP_168236465.1\|4523079_4523703_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|225222
NZ_CP050994.1\|WP_168236462.1\|4517553_4518693_-\|chromate-efflux-transporter	unknown	unknown	gnl\|CDD\|273350
NZ_CP050994.1\|WP_005324617.1\|4526973_4527813_+\|isopenicillin-N-synthase-family-oxygenase	unknown	unknown	gnl\|CDD\|226022
NZ_CP050994.1\|WP_106884898.1\|4534882_4535479_+\|LysE-family-translocator	unknown	unknown	gnl\|CDD\|224199
NZ_CP050994.1\|WP_168236468.1\|4529760_4531074_+\|sodium-dependent-transporter	unknown	unknown	gnl\|CDD\|271367

Protein	Function_ID	Function_description	E-value
NZ_CP050994.1\|WP_163137780.1\|4518885_4519326_-\|NUDIX-domain-containing-protein	gnl\|CDD\|240034	cd04678, Nudix_Hydrolase_19, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	3.12625e-51
NZ_CP050994.1\|WP_106884903.1\|4526211_4526775_-\|DUF2799-domain-containing-protein	gnl\|CDD\|378521	pfam10973, DUF2799, Protein of unknown function (DUF2799). Some members in this family of proteins are annotated as yfiL which has no known function.	1.11133e-24
NZ_CP050994.1\|WP_168236466.1\|4523870_4525109_+\|MFS-transporter	gnl\|CDD\|340888	cd17330, MFS_SLC46_TetA_like, Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.32369e-40
NZ_CP050994.1\|WP_168236471.1\|4535581_4536172_+\|LysE-family-translocator	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	1.66388e-28
NZ_CP050994.1\|WP_025325819.1\|4522293_4522770_-\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	4.14903e-47
NZ_CP050994.1\|WP_168236463.1\|4519866_4520871_-\|NADP-dependent-oxidoreductase	gnl\|CDD\|176190	cd05288, PGDH, Prostaglandin dehydrogenases. Prostaglandins and related eicosanoids are metabolized by the oxidation of the 15(S)-hydroxyl group of the NAD+-dependent (type I 15-PGDH) 15-prostaglandin dehydrogenase (15-PGDH) followed by reduction by NADPH/NADH-dependent (type II 15-PGDH) delta-13 15-prostaglandin reductase (13-PGR) to 15-keto-13,14,-dihydroprostaglandins. 13-PGR is a bifunctional enzyme, since it also has leukotriene B(4) 12-hydroxydehydrogenase activity. These 15-PGDH and related enzymes are members of the medium chain dehydrogenase/reductase family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES.	8.03261e-166
NZ_CP050994.1\|WP_162627388.1\|4521070_4521496_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	5.63339e-21
NZ_CP050994.1\|WP_005324594.1\|4521901_4522219_+\|hypothetical-protein	gnl\|CDD\|225653	COG3111, COG3111, Periplasmic protein with OB-fold [Function unknown].	0.000215846
NZ_CP050994.1\|WP_168236470.1\|4533392_4534766_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	5.08149e-99
NZ_CP050994.1\|WP_168236473.1\|4537202_4538417_+\|aldose-1-epimerase-family-protein	gnl\|CDD\|379620	pfam14486, DUF4432, Domain of unknown function (DUF4432).	6.32533e-148
NZ_CP050994.1\|WP_168236474.1\|4538492_4540283_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|223953	COG1022, FAA1, Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism].	0
NZ_CP050994.1\|WP_168236461.1\|4517090_4517483_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	gnl\|CDD\|376583	pfam01641, SelR, SelR domain. Methionine sulfoxide reduction is an important process, by which cells regulate biological processes and cope with oxidative stress. MsrA, a protein involved in the reduction of methionine sulfoxides in proteins, has been known for four decades and has been extensively characterized with respect to structure and function. However, recent studies revealed that MsrA is only specific for methionine-S-sulfoxides. Because oxidized methionines occur in a mixture of R and S isomers in vivo, it was unclear how stereo-specific MsrA could be responsible for the reduction of all protein methionine sulfoxides. It appears that a second methionine sulfoxide reductase, SelR, evolved that is specific for methionine-R-sulfoxides, the activity that is different but complementary to that of MsrA. Thus, these proteins, working together, could reduce both stereoisomers of methionine sulfoxide. This domain is found both in SelR proteins and fused with the peptide methionine sulfoxide reductase enzymatic domain pfam01625. The domain has two conserved cysteine and histidines. The domain binds both selenium and zinc. The final cysteine is found to be replaced by the rare amino acid selenocysteine in some members of the family. This family has methionine-R-sulfoxide reductase activity.	7.56371e-71
NZ_CP050994.1\|WP_168236472.1\|4536259_4536952_+\|aspartate/glutamate-racemase-family-protein	gnl\|CDD\|224707	COG1794, RacX, Aspartate racemase [Cell envelope biogenesis, outer membrane].	5.31156e-108
NZ_CP050994.1\|WP_168236465.1\|4523079_4523703_-\|transcriptional-regulator	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	8.28711e-56
NZ_CP050994.1\|WP_168236462.1\|4517553_4518693_-\|chromate-efflux-transporter	gnl\|CDD\|273350	TIGR00937, Chromate_transport_protein, chromate transporter, chromate ion transporter (CHR) family. Members of this family probably act as chromate transporters, and are found in Pseudomonas aeruginosa, Alcaligenes eutrophus, Vibrio cholerae, Bacillus subtilis, Ochrobactrum tritici, cyanobacteria and archaea. The protein reduces chromate accumulation and is essential for chromate resistance. [Transport and binding proteins, Anions].	2.03407e-66
NZ_CP050994.1\|WP_005324617.1\|4526973_4527813_+\|isopenicillin-N-synthase-family-oxygenase	gnl\|CDD\|226022	COG3491, PcbC, Isopenicillin N synthase and related dioxygenases [General function prediction only].	1.02692e-36
NZ_CP050994.1\|WP_106884898.1\|4534882_4535479_+\|LysE-family-translocator	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	4.27836e-25
NZ_CP050994.1\|WP_168236468.1\|4529760_4531074_+\|sodium-dependent-transporter	gnl\|CDD\|271367	cd10336, SLC6sbd_Tyt1-Like, solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain. SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter. An arrangement of 12 transmembrane (TM) helices appears to be as a common topological motif for eukaryotic and some prokaryotic and archaeal NTTs. However, this subfamily which contains the majority of bacterial members and some archaeal members, appears to contain only 11 TMs; for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.	3.23224e-167

>NZ_CP050994.1|WP_168236466.1|4523870_4525109_+|MFS-transporter
MEGIKGQATLWVLVMTVTLAMAGFSLPSPVLAPLMLDPAQGMLTPQASDWSRKLWLGVIMGLYPLFQLLGAPWLGKLSDRHGRKPVLTLCLVGVLAGYVLMALGIAWRSLPLLLLSRVVEGFFNGDIAIVQAMAADMSTTRTKARNFARINIGMNLGWVLGPMIGGYAAVVSGDYSLAAWLAVAMTVGNLLLVLWLLPNRPPVPAEQELASLSTRQLLLQPRLLPYFVLTLLSYGAVQLYFTYFNVWLVERLAWDPVQLAQAAVLVSVPMMLGSWLGEQLARHWRGSSLGIVGHLVMAAGMLMFILPTQWWGLALTFIPAGIGMSLGELATSVAISNRSHASQQGQAMGIYRGLAVGSEILAVVLGSLALLAGTEWPFYLAALCGVICALGFYGLRRRADRRSAVAACAEPG
>NZ_CP050994.1|WP_168236465.1|4523079_4523703_-|transcriptional-regulator
MNASTDKILYLLKTHGPQSAAALGEQLQMTSMGARQHLTALEADGWVGFSDEARGRGRPIRLWHLTDQAWQRFPDTHSELTLQLIDDVQQLFGESGLDQLIARREQQMLSRYQARLTQPALADRLTALKELRSREGYMADMSQEEDGSWLWWESHCPICAAARACRGFCRSELALFRQLLAPAGVEREQYLLDGDRRCLYRIRPPQA
>NZ_CP050994.1|WP_025325819.1|4522293_4522770_-|Lrp/AsnC-family-transcriptional-regulator
MLKLDRIDRHILELMQENGRISNLELAELVGLSPSPCSRRVKALEDAGLIDTHVTLLNARQLGLTLTAYIHISMDRHTPERFENFDRAIQDLPEVLECDLITGNDADYQLKVVVRDMEHYQHFLLDKLTHISGVTGVRSSFVLRRIKHKTALPLNHLG
>NZ_CP050994.1|WP_005324594.1|4521901_4522219_+|hypothetical-protein
MQSSIVGLSILWGLASFGVQGDFIESRDSVAPSWQAESRVEMEGYLIESLGEDRWVFDNGSESLLVSLPEGQWVSEGERLRLSGEPQQEQAGWLLQVQDVSQVGV
>NZ_CP050994.1|WP_168236464.1|4521526_4521757_+|hypothetical-protein
MKPWLPLLALLLSACVDTSYPRSELQIDDADAWQALCKDGVRVRAISEEGICADHRGLAMWTNKPRAVRMAEEAAK
>NZ_CP050994.1|WP_162627388.1|4521070_4521496_+|MarR-family-transcriptional-regulator
MSELKKQVCFALYSASNAVMRAYRPLLDKLDLTYTQYLVMLSLWARDEVSLKEIGQETGLDAGTLTPIVKRLESKGWLTRTVSSEDERQKCIRLTEAGRQLQQGVRECCLADNLRNQVDLADAELAELKRLCDRVATQLGR
>NZ_CP050994.1|WP_168236463.1|4519866_4520871_-|NADP-dependent-oxidoreductase
MTPISHQIQLLRRPTGLPVQSDFILKEVPLPALQEGEVQVANQWLSVDPYMRGRMSEAKSYVPPFPLNGPLDGGAIGTVQASRHPDFKVGDQVSSMLGWRDAFVAKGEQLTRLPATALPSQLFLGALGMPGMTAWAGLHKVARLQAGETLLVSAASGAVGTMAVQLAKRAGARVIGSTGSADKVAYLKTLGADAVINYRETPDLDAELARLAPEGIQVYFENVGGAMLDAALNNMALHGRIVLCGLIEQYNSNGQGSGPRNLSQMIRKRILMQGLLVSDHWQHYGDFLAEAIPAFEAGALQAEETISEGLASMPQAFIGLFEGRNTGKMLVKLG
>NZ_CP050994.1|WP_163137780.1|4518885_4519326_-|NUDIX-domain-containing-protein
MSTPYPRVGVGVILVNHQGQVLLGKRKGSHAPYWSIAGGHLELGESFESAAIREVAEETGFLITNPSVIAVTNNLETWRESGLHYISVTLLAEVEGEPQLLEPDKCEGWVWCDPHALPEPHFDASRQSIACWLAGRCYLPQPGQPT
>NZ_CP050994.1|WP_168236462.1|4517553_4518693_-|chromate-efflux-transporter
MGQVFLQFLWLGCISFGGPAAHIGYFQRTFVQRLGWLSQAEYAQLLALCQLLPGPASSQLGFAIGRHRAGLGGALAAFIGFTLPSFLLLLAAAIGLGQLTNNLWLDAALHGLKLLALVVVADAVLTMSRQFCKTVLQQGVMVATAAALWWQPGLLTQLGMLLGAALLCAQRETVGASPATPQARRVPHWPTLLLFALLFAGLPLLTQGPASQLVADFYRAGSLVFGGGHVVLPLLQESVGHSLSQQQFLTGYGLAQLVPGPMFTLASYLGAQLLPATPLTGALLATLALFLPGFLLLWALGPCWQSWLAHPRLAGAVAGINAAVVGLLLAALYQPVWQSAVLAPADLALAAVAFYLLRVIRLPILALAALLVGASLLLI
>NZ_CP050994.1|WP_168236461.1|4517090_4517483_+|peptide-methionine-(R)-S-oxide-reductase-MsrB
MSGNNPEQWRSKLSAEQFHVCWEKGTGRPYSGALLHNRKSGDYLCVCCKSVLFHADAKFDSGCGWPSFDRAIEGTVTYTEDRSHGMARVEITCSQCGSHLGHVFPDGPTETGQRYCVNSLSLDFEPDTDA
>NZ_CP050994.1|WP_106884903.1|4526211_4526775_-|DUF2799-domain-containing-protein
MSPKILLLTLPLLLAGCSSLSEEECRAMSWYNQGYQDGEQGKTRTATRDYKQTCGEYGLRVDEDEWQRGYAKGLELYCIPELAYSKGREGNEYLGVCPNDTSFLTQFERGRKEFLLEQRLGELQQELERTERTIYQLDQQIRGESDSKQRDYYRAQRERAIRHYEGVRRDYNRIRFPDRVIQFSFGS
>NZ_CP050994.1|WP_005324617.1|4526973_4527813_+|isopenicillin-N-synthase-family-oxygenase
MKVLTVDYRSPDAAERFTESLRTTGFGVLTHHPIPKELVQSIYDNWYRFFMSEQKQDFLFNRETQDGYFPPSVSEVAKGNTQKDIKEYFHLYPWGQMPEELRAQAMEYYRLANDLAAELLSWVEQYTPADIAAHYSCPLSSMIEESQKTLLRVLHYPPFDGTEAPGAIRAAAHEDINLLTILPAASEPGLQVKGSDGEWMDVPCDFGTLIINIGDMLQEASHGYYPSTTHRVINPTGGSVSKSRISLPLFLHPRPDVVLSERHTAHSYLMERLRELGVI
>NZ_CP050994.1|WP_168236468.1|4529760_4531074_+|sodium-dependent-transporter
MSQVQWSSRLGHVLAAAGTAIGLGAIWKFPYVTATNGGGAFLLVFLLFSFTLGVAVLVGETLLGSRSQRGVLGAFHRLVGPNWRWMGYMGILCGFFIYSFYSVVGGWTVGYAALAVMGKLNLGEGSALTALFNGYVSHPWWPVLTHLVFAGLTWWFVQGGIQKGVERALRWMMPALFVMMLLLVGVGLSMPGAMAGVRQLLLPDFSMLTGQSVLDALGLAFFSLSIGLGVHTTYGAYLPNSEGVLRSGVWVVTLASLISVLAGLMIFPALASTGIDPTAGPGLTFMTMPAVFSHLPFGQGLGVVFFLLLLVAALSSSISMLEHLVRFTCEEWGWSRRGACRVLTLMIMASGIPVSLSFGPWADYTLFGKTIFDLLDYLTSNLMMPLFGLVLTLLLGWRLGDTILPEGLSPALRLCLLWCWRLVAPLLIAGILVRGLL
>NZ_CP050994.1|WP_168236469.1|4532898_4533363_-|hypothetical-protein
MLPVRPALLLITLLLGGCASPAHRQLGQALSGLEGELQRLEEELAAMNGLHYQKAIDAPLALRRYLSTPSPTAEGLVPAQSQLQDGPLLRYDYHLPAPMTLLPTDNPCLRYEFELRHLGRLGQLELVWQGSGHQGSQLIRQRDCPFSARGPGLQ
>NZ_CP050994.1|WP_168236470.1|4533392_4534766_-|PLP-dependent-aminotransferase-family-protein
MTIWTPNLTPFEGPLYLKLVKAIEQAIADGALPPQTRLPTHRALADRLGVTVGTITRAYTEAERRGLLAARVGHGTWVRAAADPANEWVIRNEDNQRIELWQNLPVQLDRAAIIKPMLTELADGDLNGLLGYDKEAGRAPQRQLFVDWLAEQGIRGSEERLLFSHGAQHGIMLALLATGCVGETLFCEGLSYPGMLGNARQLKNQVMGLAMDEEGLLPAALEAACRQRRAKLLYLTPTLQNPTTATMSLARREEIVAIARRHDLLIVEDDVNGLLPEEMLPPLVNLAPERVIYLGSLAKIACGGLRVGFVLAPPALRHGFAQAMRLSSWMVSPLLIELACKLVSQHQIMPLIEQQRRILARRGELLRHLLPGARWQPGAMHAWLPLPEPWRSQEFAEAANALDVGVASGEHFAAGQFAAPQGVRLSLSQPATDARVAEGLERLAGLLRAAPPTNPLL
>NZ_CP050994.1|WP_106884898.1|4534882_4535479_+|LysE-family-translocator
MTIEWYATLFGFALLTCGTPGPNNLMLTASGANFGVRRTLPHLIGVVVGQPVLQLVLALGFYPLFERWPLLKLSLQVLGSLYLLWLAWRIAVAGAPGDPARRARPLTLLEGLGFQFLNPKAWMMGISAISLFSLPGSDYWASMWGIMSVFPMAGLPVCFAWVLFGHQLSRWINSDRGWRRLNGSLGALTALCVVMLWY
>NZ_CP050994.1|WP_168236471.1|4535581_4536172_+|LysE-family-translocator
MDLNWLFPLVGFALITCGTPGPNNMLLTSAGAAQGFRRSIPLLVGVVGGINLMILATALGLGVVFEKVPLLHDGLKLVGSAYLLWLAWKVATASGPADGSRPLIPAHQGAMLQLLNPKAWMMALSAISGFTLAGEAYWPSAGWVLGIFFVTGLYTGAFWVLFGAQVRRLIRTARGWRRFNLGMGIATAACVLMIWI
>NZ_CP050994.1|WP_168236472.1|4536259_4536952_+|aspartate/glutamate-racemase-family-protein
MKCIGLLGGMSWESTVSYYQALNRGVRARLGGLHSARVLLNSVDFAEIERLQHAGDWPATARLLAAEARALQAGGADFLMIGTNTMHKVAPEIAAAIEIPLLHIADATARRLQADGVTRVGLLGTRFTMEQDFYKGRLQELFGLEVLVPGDAARERVHSIIYDELCLGQIRESSRAEYLAIIADLARAGAQAVILGCTEIALLVGECQAAVPLYDTTAIHADAAVAWALE
>NZ_CP050994.1|WP_168236473.1|4537202_4538417_+|aldose-1-epimerase-family-protein
MLKRLSIAVLLALGASSAQAAEFLLTDSQQGLDVGDWKITSDKLGIKSPVPFSIEKKRLHGGRQEGVDLLIVDNGVMKITLVPTRGMGIKEVKGADVRLGWDSPVKEVVNPAFIDLESRAGLGWLDGFNEMLVRCGYEWTGHPGVDDDGRLKSLHGRVQNIPASVVSVTVDEEPPYAIHVRGRVDERTFKMSELVTWTQLSVVPGQAEFALQDKLTNHADYENEYQIIYHGNFGAPILEEGARVSTPVKQISPFNDYAKAGLKGWQSYLGPTKGFDEMVFNLVPYSDAEGNTLAVLNNKAGNVGVAVGYNTHQLPVLTLWKNTDTRAQGYVTGIEPGTSYAYSTKYQRPLGLVPRIQPGETKTFDLTYRLLQNADEVTQALAQVEKIQAGRPTELREQPLVKLP
>NZ_CP050994.1|WP_168236474.1|4538492_4540283_-|long-chain-fatty-acid--CoA-ligase
MSQLHLVRVMRERIARLGNKAALRVQQDGQWRAIGWRTLGQAMDYCAQALIRAGHQPTEMVGIYARNMPEWTQADLGILAARGVSVPIYPTSTLDQLRYIVKDAGIKLLFVGEQPQFDQALLLLESGEINQIVTLDGTVDLRGCEQASHFQTFLSSGNHQPSELALRMREQHYRMDDLLTLIYTSGTTGEPKGVMLDFNNIAACFEMHDRRLDLGEQDVSLCMLPLSHVFERAWSYYVLYCGAENVYIRDPQKVMDVIGEVQPTVMCAVPRLYEKAYAMIQAKVAQAPRLRRALFGWATGVGKRMVATRQAGKSASPLLYLQLALAERLVFRKLRARFGGRTRFLPVAGARLADDVNLFFQAMGLNLKYGYGMTETTATVCCYEDSQFKLGSIGTVMDGIEVKLGENNELLVRSPTVMRGYYNKPEATAEVMTADGFLRTGDAGELDDEGNIYFTERLKELMKTSNGKYVAPQLVEGTLGKDRFIEQIAIVADARHFVSALIVPCFESLEEYARSINLQYQCKTELLRHSKVVEFFEARIADLQQELAKFEQVKKFTLLPSAFSMELGEITPTMKLRRKIIESKYQSEIEAMYSHV

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP050994_8	8.1\|2007952\|52\|NZ_CP050994\|CRISPRCasFinder	2007952-2008003	52	NZ_CP050994.1	2008055-2008106	2	0.962

1. spacer 8.1|2007952|52|NZ_CP050994|CRISPRCasFinder matches to position: 2008055-2008106, mismatch: 2, identity: 0.962

ccaccgcggcgctgatgtggtattgattggcacgccagagggcgtagtcacg	CRISPR spacer
ccatcgcggcgctgacgtggtattgattggcacgccagagggcgtagtcacg	Protospacer
***.***********.************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP050994_23	23.1\|4518863\|27\|NZ_CP050994\|CRISPRCasFinder	4518863-4518889	27	NZ_LN907828	Erwinia gerundensis isolate E_g_EM595 plasmid pEM01, complete sequence	423680-423706	5	0.815
NZ_CP050994_7	7.1\|1774926\|28\|NZ_CP050994\|CRISPRCasFinder	1774926-1774953	28	NC_009426	Novosphingobium aromaticivorans DSM 12444 plasmid pNL1, complete sequence	64032-64059	6	0.786
NZ_CP050994_7	7.1\|1774926\|28\|NZ_CP050994\|CRISPRCasFinder	1774926-1774953	28	NC_002033	Novosphingobium aromaticivorans plasmid pNL1, complete sequence	7425-7452	6	0.786
NZ_CP050994_7	7.1\|1774926\|28\|NZ_CP050994\|CRISPRCasFinder	1774926-1774953	28	AP018399	Xanthomonas phage XacN1 DNA, complete genome	303099-303126	7	0.75
NZ_CP050994_7	7.1\|1774926\|28\|NZ_CP050994\|CRISPRCasFinder	1774926-1774953	28	NZ_CP044308	Escherichia coli strain C27A plasmid pC27A-3, complete sequence	28165-28192	7	0.75

1. spacer 23.1|4518863|27|NZ_CP050994|CRISPRCasFinder matches to NZ_LN907828 (Erwinia gerundensis isolate E_g_EM595 plasmid pEM01, complete sequence) position: , mismatch: 5, identity: 0.815

cgccagccagtgcactatggggattag	CRISPR spacer
cgccagccagagcactatggtgatgtt	Protospacer
********** ********* ***

2. spacer 7.1|1774926|28|NZ_CP050994|CRISPRCasFinder matches to NC_009426 (Novosphingobium aromaticivorans DSM 12444 plasmid pNL1, complete sequence) position: , mismatch: 6, identity: 0.786

gcggtgttattccatcgccagcatcaat	CRISPR spacer
gaggcgttattccatcgccagcattccg	Protospacer
* **.*******************.

3. spacer 7.1|1774926|28|NZ_CP050994|CRISPRCasFinder matches to NC_002033 (Novosphingobium aromaticivorans plasmid pNL1, complete sequence) position: , mismatch: 6, identity: 0.786

gcggtgttattccatcgccagcatcaat	CRISPR spacer
gaggcgttattccatcgccagcattccg	Protospacer
* **.*******************.

4. spacer 7.1|1774926|28|NZ_CP050994|CRISPRCasFinder matches to AP018399 (Xanthomonas phage XacN1 DNA, complete genome) position: , mismatch: 7, identity: 0.75

gcggtgttattccatcgccagcatcaat	CRISPR spacer
agaacggtattccatcgccagcatcaac	Protospacer
. ...* ********************.

5. spacer 7.1|1774926|28|NZ_CP050994|CRISPRCasFinder matches to NZ_CP044308 (Escherichia coli strain C27A plasmid pC27A-3, complete sequence) position: , mismatch: 7, identity: 0.75

gcggtgttattccatcgccagcatcaat	CRISPR spacer
cgcctgttattcgatcgccagcttcaaa	Protospacer
    ******** ********* ****

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

671378 : 679480

Enterobacteria_phage(42.86%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_042649691.1\|671378_672053_-	response regulator	W8CYM9	Bacillus_phage	1.2e-26	32.9
WP_168234708.1\|673027_674113_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	2.9e-96	51.6
WP_168234709.1\|674112_675000_+	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	1.8e-27	34.5
WP_168234710.1\|675113_675992_+	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	1.8e-104	63.1
WP_168234711.1\|675997_676555_+	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	2.7e-53	58.6
WP_139744465.1\|676545_676947_+	WxcM-like domain-containing protein	NA	NA	NA	NA
WP_139744466.1\|676946_677414_+	N-acetyltransferase	NA	NA	NA	NA
WP_139744467.1\|677410_678529_+	aminotransferase class V-fold PLP-dependent enzyme	E5ES42	Bathycoccus_sp._RCC1105_virus	1.1e-42	31.0
WP_139744468.1\|678532_679480_+	glycosyltransferase	A0A0F7L2F7	uncultured_marine_virus	2.5e-06	34.3

DBSCAN-SWA_2

802688 : 818648

Vibrio_phage(28.57%)

head

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_168234767.1\|802688_803309_+	DUF3164 family protein	A0A2I7S9B0	Vibrio_phage	6.0e-62	59.4
WP_168234768.1\|803322_803517_+	hypothetical protein	NA	NA	NA	NA
WP_168234769.1\|803598_803811_+	hypothetical protein	NA	NA	NA	NA
WP_168234770.1\|803912_804143_+	hypothetical protein	NA	NA	NA	NA
WP_168234771.1\|804129_804297_+	hypothetical protein	NA	NA	NA	NA
WP_168234772.1\|804293_804872_+	regulatory protein GemA	A0A2I7S9B8	Vibrio_phage	3.9e-23	37.1
WP_168236517.1\|804873_805311_+	transcriptional regulator	NA	NA	NA	NA
WP_168234773.1\|805388_806471_+	DNA cytosine methyltransferase	M1PSQ0	Streptococcus_phage	1.4e-37	31.5
WP_168234774.1\|806497_807448_+	HNH endonuclease	NA	NA	NA	NA
WP_168234775.1\|807577_808177_+	secretion activator protein	A2I317	Vibrio_virus	2.2e-16	32.8
WP_168234776.1\|808173_808476_+	hypothetical protein	NA	NA	NA	NA
WP_168234777.1\|808468_808690_+	hypothetical protein	NA	NA	NA	NA
WP_168234778.1\|808711_808939_+	TraR/DksA family transcriptional regulator	NA	NA	NA	NA
WP_168234779.1\|808919_809222_+	DUF2730 family protein	M4M9P7	Vibrio_phage	3.3e-05	33.0
WP_168234780.1\|809218_809515_+	ArsR family transcriptional regulator	A0A0C4UR00	Shigella_phage	1.1e-16	57.0
WP_168234781.1\|809517_810093_+	DUF3486 family protein	A0A0C4UQU5	Shigella_phage	4.4e-59	67.6
WP_168234782.1\|810092_811637_+	hypothetical protein	A0A2I7S9C5	Vibrio_phage	1.1e-165	61.5
WP_168234783.1\|811636_813208_+	DUF935 domain-containing protein	J9SVY0	Pseudomonas_phage	2.5e-120	47.9
WP_168234784.1\|813207_814677_+	F protein	A0A2H4IYU7	uncultured_Caudovirales_phage	1.1e-61	50.4
WP_168234785.1\|814696_814897_+	hypothetical protein	NA	NA	NA	NA
WP_168234786.1\|814896_815343_+	phage virion morphogenesis protein	Q5ZQY1	Pseudomonas_phage	2.6e-14	32.8
WP_168234787.1\|815545_816688_+	hypothetical protein	A0A0C4UQU6	Shigella_phage	9.4e-61	42.4
WP_168234788.1\|816747_817656_+\|head	head protein	A0A0C4UQR9	Shigella_phage	1.9e-104	59.9
WP_168234789.1\|817775_818231_+	hypothetical protein	NA	NA	NA	NA
WP_168234790.1\|818234_818648_+	DUF1320 family protein	B7SDP4	Haemophilus_phage	1.2e-13	36.2

DBSCAN-SWA_3

1531599 : 1542720

Hokovirus(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_168236537.1\|1531599_1535523_-	transporter substrate-binding domain-containing protein	A0A1V0SGX0	Hokovirus	2.7e-30	35.2
WP_005300715.1\|1535577_1535874_-	integration host factor subunit alpha	A0A0H3UZA0	Geobacillus_virus	3.0e-11	35.6
WP_168235140.1\|1535877_1538265_-\|tRNA	phenylalanine--tRNA ligase subunit beta	A0A1L3IZU3	BeAn_58058_virus	6.2e-06	25.5
WP_106886730.1\|1538277_1539261_-\|tRNA	phenylalanine--tRNA ligase subunit alpha	A0A2H4UW22	Bodo_saltans_virus	5.3e-36	38.2
WP_010674800.1\|1539585_1539942_-	50S ribosomal protein L20	NA	NA	NA	NA
WP_005315535.1\|1539956_1540154_-	50S ribosomal protein L35	NA	NA	NA	NA
WP_041204270.1\|1540239_1540788_-	translation initiation factor IF-3	A0A2L0UZ54	Agrobacterium_phage	1.8e-14	37.2
WP_043131783.1\|1540791_1542720_-\|tRNA	threonine--tRNA ligase	A0A2K9L297	Tupanvirus	9.7e-127	38.0

DBSCAN-SWA_4

2994813 : 3004790

uncultured_Mediterranean_phage(25.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_106885841.1\|2994813_2996679_-	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	1.1e-34	32.6
WP_163155825.1\|2996892_2998680_-	DNA primase	A0A0K1LMQ9	Caulobacter_phage	3.0e-74	41.4
WP_042653031.1\|2998769_2999213_-	GatB/YqeY domain-containing protein	A0A292GL36	Xanthomonas_phage	1.5e-27	48.6
WP_005309452.1\|2999227_2999443_-	30S ribosomal protein S21	NA	NA	NA	NA
WP_043131995.1\|2999622_3000636_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	3.1e-108	58.6
WP_043131996.1\|3000723_3001707_-	RNA polymerase sigma factor RpoS	F4YCU2	Synechococcus_phage	4.9e-34	33.7
WP_139745772.1\|3001753_3002818_-	LysM peptidoglycan-binding domain-containing protein	A0A0A7NU10	Lactobacillus_phage	6.3e-11	36.2
WP_005332743.1\|3003406_3004024_-	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	2.4e-34	46.4
WP_139745771.1\|3004028_3004790_-	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	5.6e-70	53.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP050994

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection