CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP051184	Bermanella marisrubri strain RED65 plasmid pBma45, complete sequence	1 crisprs	NA	0	2	0	0
NZ_CP051183	Bermanella marisrubri strain RED65 chromosome, complete genome	8 crisprs	csa3,DEDDh,cas3,WYL,DinG	0	0	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP051184_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP051184_1

8652-8836

Orphan

Consensus_repeat	Method
GAGTTCCCGCATGCGGGAATT	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP051184_1

>merge|NZ_CP051184|1|8652-8836|PILER-CR
AGTTCCCGCATGCGGGAATTATTTTCCTTTGTTGTTTCTCTTCTAAAAATAACAGTTAAAACTTTTTTTAAAGCCAATTTTAGAAGAATGTTTGAGAGTTCCCGCATGCGGGAATTTCTCAAATATCAGGGCTTAAAAAATCGGTTCTTAACTCGAAATTGGGTGAGTTCCCGCATGCGGGAACT

>NZ_CP051184|1|1|8652-8836|PILER-CR
AGTTCCCGCATGCGGGAATTA	TTTTCCTTTGTTGTTTCTCTTCTAAAAATAACAGTTAAAACTTTTTTTAAAGCCAATTTTAGAAGAATGTTTGAG
AGTTCCCGCATGCGGGAATTT	CTCAAATATCAGGGCTTAAAAAATCGGTTCTTAACTCGAAATTGGGTG
AGTTCCCGCATGCGGGAACT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP051184.1\|WP_040298375.1\|14782_15178_+\|TraV-family-lipoprotein	unknown	unknown	gnl\|CDD\|370611
NZ_CP051184.1\|WP_168367089.1\|3194_3503_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051184.1\|WP_007019388.1\|9562_10327_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051184.1\|WP_007019386.1\|6499_8515_-\|type-IV-secretion-system-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|274760
NZ_CP051184.1\|WP_007019393.1\|12261_12846_+\|type-IV-conjugative-transfer-system-protein-TraE	unknown	unknown	gnl\|CDD\|377500
NZ_CP051184.1\|WP_007019389.1\|10622_11057_+\|lytic-transglycosylase-domain-containing-protein	unknown	unknown	gnl\|CDD\|381603
NZ_CP051184.1\|WP_168367091.1\|12838_13543_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368991
NZ_CP051184.1\|WP_007019384.1\|4708_5911_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376986
NZ_CP051184.1\|WP_007019391.1\|11631_11919_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051184.1\|WP_007019392.1\|11971_12259_+\|type-IV-conjugative-transfer-system-protein-TraL	unknown	unknown	gnl\|CDD\|377786
NZ_CP051184.1\|WP_168367090.1\|3674_4562_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051184.1\|WP_168367088.1\|972_3066_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236078
NZ_CP051184.1\|WP_007019348.1\|15178_17728_+\|type-IV-secretion-system-protein-TraC	unknown	unknown	gnl\|CDD\|274279
NZ_CP051184.1\|WP_007019346.1\|13542_14790_+\|TraB-pilus-assembly	unknown	unknown	gnl\|CDD\|319756
NZ_CP051184.1\|WP_165837050.1\|11235_11616_+\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|143586

Protein	Function_ID	Function_description	E-value
NZ_CP051184.1\|WP_168367091.1\|12838_13543_+\|hypothetical-protein	gnl\|CDD\|368991	pfam06586, TraK, TraK protein. This family consists of several TraK proteins from Escherichia coli, Salmonella typhi and Salmonella typhimurium. TraK is known to be essential for pilus assembly but its exact role in this process is unknown.	4.14504e-34
NZ_CP051184.1\|WP_007019384.1\|4708_5911_+\|hypothetical-protein	gnl\|CDD\|376986	pfam03090, Replicase, Replicase family. This is a family of bacterial plasmid DNA replication initiator proteins. pfam01051 is a similar family. These RepA proteins exist as monomers and dimers in equilibrium: monomers bind directly to repeated DNA sequences and thus activate replication; dimers repress repA transcription by binding an inversely repeated DNA operator. Dimer dissociation can occur spontaneously or be mediated by Hsp70 chaperones.	2.10441e-42
NZ_CP051184.1\|WP_007019393.1\|12261_12846_+\|type-IV-conjugative-transfer-system-protein-TraE	gnl\|CDD\|377500	pfam05309, TraE, TraE protein. This family consists of several bacterial sex pilus assembly and synthesis proteins (TraE). Conjugal transfer of plasmids from donor to recipient cells is a complex process in which a cell-to-cell contact plays a key role. Many genes encoded by self-transmissible plasmids are required for various processes of conjugation, including pilus formation, stabilisation of mating pairs, conjugative DNA metabolism, surface exclusion and regulation of transfer gene expression. The exact function of the TraE protein is unknown.	8.12452e-43
NZ_CP051184.1\|WP_007019392.1\|11971_12259_+\|type-IV-conjugative-transfer-system-protein-TraL	gnl\|CDD\|377786	pfam07178, TraL, TraL protein. This family consists of several bacterial TraL proteins. TraL is a predicted peripheral membrane protein which is thought to be involved in bacterial sex pilus assembly. The exact function of this family is unclear.	6.95596e-12
NZ_CP051184.1\|WP_165837050.1\|11235_11616_+\|OmpA-family-protein	gnl\|CDD\|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	2.79478e-24
NZ_CP051184.1\|WP_040298375.1\|14782_15178_+\|TraV-family-lipoprotein	gnl\|CDD\|370611	pfam09676, TraV, Type IV conjugative transfer system lipoprotein (TraV). This entry includes TraV, which is a component of conjugative type IV secretion system. TraV is an outer membrane lipoprotein that is believed to interact with the secretin TraK. The alignment contains three conserved cysteines in the N-terminal half.	3.01739e-10
NZ_CP051184.1\|WP_007019386.1\|6499_8515_-\|type-IV-secretion-system-DNA-binding-domain-containing-protein	gnl\|CDD\|274760	TIGR03743, SXT_TraD, conjugative coupling factor TraD, SXT/TOL subfamily. Members of this protein family are the putative conjugative coupling factor, TraD (or TraG), rather distantly related to the well-characterized TraD of the F plasmid. Members are associated with conjugative-transposon-like mobile genetic elements of the class that includes SXT, an antibiotic resistance transfer element in some Vibrio cholerae strains. [Mobile and extrachromosomal element functions, Other].	5.54827e-11
NZ_CP051184.1\|WP_168367088.1\|972_3066_-\|hypothetical-protein	gnl\|CDD\|236078	PRK07726, PRK07726, DNA topoisomerase 3.	0
NZ_CP051184.1\|WP_007019348.1\|15178_17728_+\|type-IV-secretion-system-protein-TraC	gnl\|CDD\|274279	TIGR02746, hypothetical_protein, type-IV secretion system protein TraC. The protein family described here is common among the F, P and I-like type IV secretion systems. Gene symbols include TraC (F-type), TrbE/VirB4 (P-type) and TraU (I-type). The protein conyains the Walker A and B motifs and so is a putative nucleotide triphosphatase.	0
NZ_CP051184.1\|WP_007019346.1\|13542_14790_+\|TraB-pilus-assembly	gnl\|CDD\|319756	cd16430, TraB, TraB is a homolog of VirB10 which forms part of core complex in Type IV secretion system (T4SS). This family contains TraB (VirB10 homolog) and a component of the type IV secretion system (T4SS), and similar proteins. T4S system is employed by pathogenic bacteria to export virulence DNAs and/or proteins directly from the bacterial cytoplasm into the host cell. It forms a large multiprotein complex consisting of 12 proteins termed VirB1-11 and VirD4. VirB10, interacts with VirB7 and VirB9, forming the membrane-spanning 'core complex' (CC), around which all other components assemble. The CC is inserted in both the outer and inner membranes, playing a fundamental role as a scaffold for the rest of the T4SS components and actively participating in T4S substrate transfer through the bacterial envelope via conformational changes regulating channel opening and closing. TraB is localized similarly to related proteins in other systems, but unlike in other systems, Neisseria gonorrhoeae TraB does not require the presence of other T4SS components for proper localization. It has been shown to be expressed with TraK (VirB9 homolog) at low levels in wild-type cells, suggesting that gonococcal T4SS may be present in single copy per cell and the small amounts of these proteins are sufficient for DNA secretion.	3.34042e-95
NZ_CP051184.1\|WP_007019389.1\|10622_11057_+\|lytic-transglycosylase-domain-containing-protein	gnl\|CDD\|381603	cd13400, LT_IagB-like, Escherichia coli invasion protein IagB and similar proteins. Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.	1.06243e-49

>NZ_CP051184.1|WP_007019386.1|6499_8515_-|type-IV-secretion-system-DNA-binding-domain-containing-protein
MSDLDRRYIEWIQSIASDMAELTNPYWFYVLTISLFLAALFSMSPLNTKADSKFSEHILVKERKLIILTWFLLFCYPLLNMWLYAASNNDYSIEGITPFLTFYLELTKQQWPLPIMGLISGLLINFMYQRYMVSLISKFKRALRFKQSNDELSDIRNEKKRFKAKDFLPSKHYDKNGIVVGLDENNKPLYIDNDTWYETNMQVVGPTRYGKGVILGGLIDQAIRRNDTVFYIDPKEDKFLPYIMYNACKEMGRKFVYVSLKDGEIGSYSPFTGGNEFDARDRIITAFDLALTGHPGTDFYKTQEQEEIDKYFSETKTIKGLASKINPDAASKLKAQLESWKRHESLCPKSGKGFSVEQALLDNAVVYIRGSLTSDILKKATKTLIIEVIQESMRLQKERQAHLSFFIDEVRFLASKQLADAMATAIGFRVNMVLAYQSILDTMTPDDQTLNGKSLTQSINVNSQVKAIYGGADTETAEWGASLSGERLKTITRLEKTEIKSGGGESWEPSRMLGSQAEHLIPANVFLSMPPRVCALYRPMHQAQICFTSFVPVKETDSLDTYIASKQPKKQYDQVKDKSPRDLKDTNAPTENNQKEKEKDSETKMNNLASVLPAPQKAEKGKRKQRRSKQKEKKQADRNIIGHEDLETGFEIDEQQITDFMSESYVDELDN
>NZ_CP051184.1|WP_007019384.1|4708_5911_+|hypothetical-protein
MEALLQNYKNDSALSRIEEFLPYKPFCSDNKTAALIRVAYSALRYDYIQVNPPEMLAWMVFDLDNHPTTGKEADPFIWQWEGLPPPNLIVTNLDNSKSHLYYAVAPVCRSKKARIKPQQYFKAVRKKLGARLGADPDFTSPVSKNPFSKNFRTLEIHNDEYSLCELDVALDEPKANAFYELPGAATEVSIGRNTTVFNWLRYWAYEAVDEARKHDFDTWTRRCHVQARRFAIKASDALGKECLKDSEIKAIAKSVSGWVWNNYNGDNIDRGIMGLNDSGLDLKKKQSLAAHRTNSMSRERNKKAVKRVILALKRAGFSNSEITRSRVAKIVGLGRKALYTTYKAVFDRYIAFPSKKASESTRKLAGALFELRTPLDLTAISVIARKIHTSATWGLDPPPD
>NZ_CP051184.1|WP_168367090.1|3674_4562_+|hypothetical-protein
MAKKIEKTQLEMPLEELLLRDISKDPEYPTLFASLPIFLPTMHRKKYDTKDWDDNSEFTYKTPFGSVSRFGPGLNIFDEDTLIGLMHIARDKKLDGHPTKMPAQLTGDGSVVVHVGETSALELNRFLRRGVSEPELEATRASVSRLSKTTLQIYSSTTDVEGDTKFFDYVGQRNVKGKFLVQFRPEVVKLFEQYVVLDFDLRTALSDTGKAVHRFLCSINKNRFSIKLDDLATAISYSGRKTDFKNTLFGTKTKPSQLEMMQKKGFIVDYELQGTGRKIPYSLSVTLNRSAELPS
>NZ_CP051184.1|WP_168367089.1|3194_3503_+|hypothetical-protein
MEFVFDAQSFKNFGLKLVVEDYGYKKELVVLSQGGSQSLSRLFESDDGFFRFSIGSQKFAIGKKDVILLVEKSEVRYYRQSSLVRLNNDRPTQVASVMKAHS
>NZ_CP051184.1|WP_168367088.1|972_3066_-|hypothetical-protein
MKLYIAEKPALANAIAKAIGIQSKCDGYYKCNNNTVVAYTAGHALELAPPDFYDEGLKQWCIADLPIVPQRFKRVVSRDKKKLYSTIKKLADKATLIVNAGDPDPEGSYIVDSLIENIGYKGPIGRVLINDLNVEAAKRGLAKESATNTTINESVSAKVRSESDWVYGLNMTRLYTCKNEIAGGEKRVLSIGRVQTSLLSIIVNRENEIKNFNPHDFYELVAEAQGIAFKCDTSEMKVSFKDPQGRVINKIEFQKFIETKPKNGTIVKKEEKERRTAPPLPYDLSNLQKECYERLKLTSSETLEIAQSLYIKHNLITYPRTDCRYVDEDCYKTSNVRISNLEQFLNITITDKIVDNYKSPAFNEQETTAHIAIIPTEKSPSDSKLNDKEKAVYKIVGERFLAQFLGPSVAAETMLTMKIDGLCYPFIAKGTVKKEIGHEWLTGIKKDKLLPDLEEGHHIPLEGVHIKTKKTSPPSYFDEKSIIDAMENAAKFIDDTEIKKLLKEAQGLGTPATQSKMVDTLEKRKYINRGKQIRPTEAGMTLFNSLAPEMQRIDMTAIWEGMLKQVRKGQLSGSAVLNSVVTHTRNLIDRSHEFQIKIGDRGPIHNCPKCDSELKRIKGQDGYFWGCSGFKSGCKYTAQDKEGKPSEKKIELSTCKLCDQTIERKYSKTKDFHFWMHQEENHECTKFIKDEKGNPVF
>NZ_CP051184.1|WP_007019388.1|9562_10327_+|hypothetical-protein
MIVHKRDADLKYPLAIKEEKTKLVLSWLLEFRFSTFEVLAGRLGQPVANANRFFNSLLDDGFIRTFKNSMVPNTRFVMLTSKGGERLSILLGEEVRPYTRLSTFAKSTKIAHDLSVQFMVLRWIDDVDEVVWDHNIAGVHELPSYSRPDALMKSTKGFWWALELERTRKSESRVFFSLYNHVLNIRNGCYVGVRYVFNSHAVCDFYRKVFEQDAWPLFDRDGRSGRLKRTSGFFKPSNVKNIDKIFDFKVGEFW
>NZ_CP051184.1|WP_007019389.1|10622_11057_+|lytic-transglycosylase-domain-containing-protein
MHKSLFLSLFFCLFSLEAQSFDACFDDAGRRFEIDPNLLRAIAHVESSMNPTAINDRGSERDIGLMQINSWWLPHLKRFGIAEKDLFHACTNIEVGSWILSENIKRHGARWDSVGVYNVGTGRGLESLKRDYVNRVYEFYSRLQ
>NZ_CP051184.1|WP_165837050.1|11235_11616_+|OmpA-family-protein
MQEGQSLLAANDDESPKQTFLSAVQFDFDSSELTGKARMKLLAKMADLQKQGVSSVSVFGFTDNVGAEAYNKNLAKDRASTVARFLANGGVQINEVVGKPLCCYLVDNESDQNRHVNRRAEIHLGN
>NZ_CP051184.1|WP_007019391.1|11631_11919_+|hypothetical-protein
MKRSVGFVIFFALSFLALSASASTTGQEFQAFYDWVFGAATGFLGRGIAITAGIIGLAIGAGMGKAIPALMGVLLAIIGSIGPTIINSLFGSALI
>NZ_CP051184.1|WP_007019392.1|11971_12259_+|type-IV-conjugative-transfer-system-protein-TraL
MAVSENYWIPRTLEDPPLFFVWEMDTAVVFLTSMIIFLLFSSPIIGFFVSLWLSKSYARVKEQGGVSLFGSFLYWYLPVDLSKRYPSFIREYVGH
>NZ_CP051184.1|WP_007019393.1|12261_12846_+|type-IV-conjugative-transfer-system-protein-TraE
MNRDVYKSVIAQMNVSRLFWASLSSLLIVSNVLLAYFVVTADTSEKTTLVPIGFESEFWVHNEEVDPEYLEQMSLFFLDLYTDYHPSNVESRFKMILKYVEPSAHGLLERRFDSEAQRIRNSSLSSTFHPSAIKIRETTVFVHGILQGLVAGKATDPDLDAVFRIDFEHDHGRLFIKTIERVIETQSGEYLAYE
>NZ_CP051184.1|WP_168367091.1|12838_13543_+|hypothetical-protein
MNNIVVFLLVALISSTAFSIQTYSVSDGDSIQIKVSSKDLTRIRMDSGRLDGAWGLDENFTHKADRSKGEIFVRPKPGAPTTSSFFIKDGNGSVYSVTAVQHAIPSDTVVLKSLDYTAKRDSSQSSRKASSDVKRIKRLVKAMARGEGLSGYSRSSKKAEVELWKNIEIVQVDSYVGRDFEGEVYAIRNSDEKDHVFHESEFRNFGEHVRFAGLDKLKIVPNETTTLYVVREAK
>NZ_CP051184.1|WP_007019346.1|13542_14790_+|TraB-pilus-assembly
MSEQEFNESNDSIDTNEDSRKKQIRNFSLVGIGLFLMVLLGLYYSDNQIKKDRQSLSAEIEEQRKKDNEILKRYKFNPSEVVKPEEKWMAKSETEFKVLKEENDSLKERLQRLEEMMEKGPDTSNNTDESVIANTQQSTPVENDQPKVKLSSPLSVESVKASVADGVAEPSIKNKKSTEIGYVDLSPMGSSNQKDKVKKNIETYMPAGAFAKVLVLSGVDAPTGGMAESNPLPVILKVLDSAILPNFFDSDIRNCHVVGAATGDLAAERVMIRTEVLSCVLANGDIIEVPIKGYIAGEDGKNGFRGRVVSKQGAVLAKSLFAGVASGLSNSINSQYQQIQTSALGTVTSIDPDKVAESGAAQGATTTLEKIADFYFKRANEIYPIIEMAPNRIGELVIIKGAKLENALVQDDGNE
>NZ_CP051184.1|WP_040298375.1|14782_15178_+|TraV-family-lipoprotein
MNRFLIVFFLIAAVGCSDKYSCNGYPDMPCASISGVYDRTKDGVRDYRSASNYDEEGNWISEEDKPSVSPNNITVSDTYNALNYVSVGDPILSEPRILRGLLFPWEDSEKDLQAGGYIYLRVEEPKWIMVE
>NZ_CP051184.1|WP_007019348.1|15178_17728_+|type-IV-secretion-system-protein-TraC
MIELLEGLNYRFKQFLTKALTVNPPGYAYAAGHEIPTIQQQKAFMNRYNLSSLFPWESYDETRGIFFNEDSVGFCLEASPSTGLSEADFKTLEGVISRKHEADSTIQFTIVADSNVDGIYKSWERSRTRNFDDPAYEIFQTLSENRRKYLLQGKWKSLFSGMPYVVRNFRLIISFTIPKPRGGNISQTTVDALSSKRESIIASLKGAKVHSKLVHPQDLINLVSALLHPTDDGYKPVNYDENSLIKDQIVSSETAFLPGRDGSSIIYRDKKVSVLPWSVRQYPQYWKGSNSDELIGSFLDNVRQIPCPFITTMSINFPDRVDEGGKIKQKTMRATQMADSAVSKFVPQWKKRASDWRYIEEKFQNGSSLVKTLYQVVLFAPQGEEESCEQALQDLYESYGWNLQKDRFIPVHGFLSALPMIFGREFVDDTNRLRRYRRMLTWNAINVSPLFGEWQGDGNNSLLMHGRRGQVMTIDPYQNKAGNFNIACSASSGAGKSFFTHEMIFSVLGEGGKVIVFDSGRSYEETVTLLGGQYLDFGDKTRTICLNPFTNIPLDEGGLKDHLPLLKILISNMASPSEDIPQIMKSALEQAIAKAFAKFRNKCSVTRVIEELLEMNSDESIELSKMLYPYSRDGVYGEYFEGDANIDLQDRFVVLELDDLAKKPGLQEIVLLILMMNINEVFYHSDRSQKKLCIIDEAWRLLQGRAGDFIEEGYRVARKYGGAFMTVTQRIADYYTSPVAQAAYANADHTWLLRQKTDELRSSIERGEIDGSKGKFEVFNSLKTEQGKYSEIAFMSPAGLGVGRLIVDPVTEKLYSTKAEEVQFLRNKRKEGVDLMTALTELAGKNNSR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP051184_1	1.2\|8769\|48\|NZ_CP051184\|PILER-CR	8769-8816	48	NZ_CP051184	Bermanella marisrubri strain RED65 plasmid pBma45, complete sequence	8768-8815	0	1.0
NZ_CP051184_1	1.1\|8673\|75\|NZ_CP051184\|PILER-CR	8673-8747	75	NZ_CP051184	Bermanella marisrubri strain RED65 plasmid pBma45, complete sequence	8672-8746	15	0.8

1. spacer 1.2|8769|48|NZ_CP051184|PILER-CR matches to NZ_CP051184 (Bermanella marisrubri strain RED65 plasmid pBma45, complete sequence) position: , mismatch: 0, identity: 1.0

tctcaaatatcagggcttaaaaaatcggttcttaactcgaaattgggt	CRISPR spacer
tctcaaatatcagggcttaaaaaatcggttcttaactcgaaattgggt	Protospacer
************************************************

2. spacer 1.1|8673|75|NZ_CP051184|PILER-CR matches to NZ_CP051184 (Bermanella marisrubri strain RED65 plasmid pBma45, complete sequence) position: , mismatch: 15, identity: 0.8

attttcctttgttgtttctcttctaaaaataacagttaaaactttttttaaagccaattt	CRISPR spacer
attttcctttgttgtttctcttctaaaaataacagttaaaactttttttaaagccaattt	Protospacer
************************************************************

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP051183_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP051183_1

416253-416390

Unclear

Consensus_repeat	Method
TGGATTCTCAGTCAAGCTGAGAATGACTTCCGACGTTGTCATACCCGACT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP051183_1

>merge|NZ_CP051183|1|416253-416390|CRISPRCasFinder
TGGATTCTCAGTCAAGCTGAGAATGACTTCCGACGTTGTCATACCCGACTTGATCGCGTATCCATTTTCCAGTTTGAAATCAATTAGGTGGATTCTCAGTCAAGCTGAGAATGACTGCCGACGTTGTCATACCCGACT

>NZ_CP051183|1|1|416253-416390|CRISPRCasFinder
TGGATTCTCAGTCAAGCTGAGAATGACTTCCGACGTTGTCATACCCGACT	TGATCGCGTATCCATTTTCCAGTTTGAAATCAATTAGG
TGGATTCTCAGTCAAGCTGAGAATGACTGCCGACGTTGTCATACCCGACT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP051183.1\|WP_007017915.1\|404492_405386_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NZ_CP051183.1\|WP_007017914.1\|403442_404384_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182990
NZ_CP051183.1\|WP_007017923.1\|419393_420569_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP051183.1\|WP_133308484.1\|428541_428955_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_007017927.1\|424629_426723_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NZ_CP051183.1\|WP_007017912.1\|401554_402022_-\|DUF4124-domain-containing-protein	unknown	unknown	gnl\|CDD\|379230
NZ_CP051183.1\|WP_007017918.1\|408169_409357_-\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383
NZ_CP051183.1\|WP_007017919.1\|409945_412660_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274612
NZ_CP051183.1\|WP_040297833.1\|426907_427870_-\|DUF1722-domain-containing-protein	unknown	unknown	gnl\|CDD\|225811
NZ_CP051183.1\|WP_007017929.1\|428139_428469_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_007017920.1\|412713_414705_+\|DUF1302-domain-containing-protein	unknown	unknown	gnl\|CDD\|377751
NZ_CP051183.1\|WP_007017924.1\|420601_421537_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NZ_CP051183.1\|WP_007017926.1\|423635_424535_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_007017921.1\|414761_416126_+\|DUF1329-domain-containing-protein	unknown	unknown	gnl\|CDD\|377764
NZ_CP051183.1\|WP_168367030.1\|402323_403436_+\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NZ_CP051183.1\|WP_007017922.1\|416596_419290_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225461
NZ_CP051183.1\|WP_007017931.1\|429104_430478_-\|PhoH-family-protein	unknown	unknown	gnl\|CDD\|224787
NZ_CP051183.1\|WP_007017916.1\|405580_406426_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|238182
NZ_CP051183.1\|WP_007017925.1\|421867_423355_+\|aromatic-hydrocarbon-degradation-protein	unknown	unknown	gnl\|CDD\|367457
NZ_CP051183.1\|WP_007017917.1\|406448_407933_-\|SulP-family-inorganic-anion-transporter	unknown	unknown	gnl\|CDD\|223732

Protein	Function_ID	Function_description	E-value
NZ_CP051183.1\|WP_007017915.1\|404492_405386_+\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	2.25418e-08
NZ_CP051183.1\|WP_007017914.1\|403442_404384_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|182990	PRK11139, PRK11139, DNA-binding transcriptional activator GcvA; Provisional.	2.27521e-59
NZ_CP051183.1\|WP_007017923.1\|419393_420569_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.56942e-08
NZ_CP051183.1\|WP_007017927.1\|424629_426723_-\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	1.96932e-19
NZ_CP051183.1\|WP_007017912.1\|401554_402022_-\|DUF4124-domain-containing-protein	gnl\|CDD\|379230	pfam13511, DUF4124, Domain of unknown function (DUF4124). This presumed domain is found in a variety of bacterial proteins. It is found associated at the N-terminus associated with other domains such as the SLT domain and glutaredoxin domains in some proteins. The function of this domain is unknown, but it may have an Ig-like fold.	0.00307233
NZ_CP051183.1\|WP_007017918.1\|408169_409357_-\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	0
NZ_CP051183.1\|WP_007017919.1\|409945_412660_+\|hypothetical-protein	gnl\|CDD\|274612	TIGR03502, lipase_Pla1_cef, extracellular lipase, Pla-1/cef family. Members of this protein family are bacterial lipoproteins largely from the Gammaproteobacteria. Characterized members are expressed extracellularly and have esterase activity. Members include the lipase Pla-1 from Aeromonas hydrophila (AF092033) and CHO cell elongation factor (cef) from Vibrio hollisae.	7.82554e-42
NZ_CP051183.1\|WP_040297833.1\|426907_427870_-\|DUF1722-domain-containing-protein	gnl\|CDD\|225811	COG3272, COG3272, Uncharacterized conserved protein [Function unknown].	4.22948e-54
NZ_CP051183.1\|WP_007017920.1\|412713_414705_+\|DUF1302-domain-containing-protein	gnl\|CDD\|377751	pfam06980, DUF1302, Protein of unknown function (DUF1302). This family contains a number of hypothetical bacterial proteins of unknown function that are approximately 600 residues long. Most family members seem to be from Pseudomonas.	0
NZ_CP051183.1\|WP_007017924.1\|420601_421537_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.56836e-89
NZ_CP051183.1\|WP_007017921.1\|414761_416126_+\|DUF1329-domain-containing-protein	gnl\|CDD\|377764	pfam07044, DUF1329, Protein of unknown function (DUF1329). This family consists of several hypothetical bacterial proteins of around 475 residues in length. The majority of family members are from Pseudomonas species but the family also contains sequences from Shewanella oneidensis and Thauera aromatica.	0
NZ_CP051183.1\|WP_168367030.1\|402323_403436_+\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	5.84184e-68
NZ_CP051183.1\|WP_007017922.1\|416596_419290_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225461	COG2909, MalT, ATP-dependent transcriptional regulator [Transcription].	2.42024e-106
NZ_CP051183.1\|WP_007017931.1\|429104_430478_-\|PhoH-family-protein	gnl\|CDD\|224787	COG1875, COG1875, NYN ribonuclease and ATPase of PhoH family domains [General function prediction only].	0
NZ_CP051183.1\|WP_007017916.1\|405580_406426_-\|universal-stress-protein	gnl\|CDD\|238182	cd00293, USP_Like, Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, athough Usp lacks ATP-binding activity.	1.26551e-15
NZ_CP051183.1\|WP_007017925.1\|421867_423355_+\|aromatic-hydrocarbon-degradation-protein	gnl\|CDD\|367457	pfam03349, Toluene_X, Outer membrane protein transport protein (OMPP1/FadL/TodX). This family includes TodX from Pseudomonas putida F1 and TbuX from Ralstonia pickettii PKO1. These are membrane proteins of uncertain function that are involved in toluene catabolism. Related proteins involved in the degradation of similar aromatic hydrocarbons are also in this family, such as CymD. This family also includes FadL involved in translocation of long-chain fatty acids across the outer membrane. It is also a receptor for the bacteriophage T2.	2.45172e-100
NZ_CP051183.1\|WP_007017917.1\|406448_407933_-\|SulP-family-inorganic-anion-transporter	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	1.13925e-145

>NZ_CP051183.1|WP_007017921.1|414761_416126_+|DUF1329-domain-containing-protein
MLLNKKIIGSAIALALSAGLAHGAVPASEAAKLGKSLTPIGAEKDGNGGAIPAWNGAIKVPASYKGDGDYVDPFAGDKVKFTITAQNYEQYKANLTDGQIAMFKKYPETYKMPVYQTRRSAGYPQKVYDETKKNATNTTLIEGGNGMANYELGVPFPIPADGLEAIWNHIVRYRGGSVSRVIGQVTPQPNGQYTIVKFNDEFTFKNKLADYDPNTMADNNILFYFKQDVVSPARLAGNVLLVHETLNQVKEPRKAWIYNAGQRRVRRAPQVAYDGPGTASDGLRTSDNFDMYNGAPDRYDWKLVGKKEVYIPYNSYKLNSKDITYDQIVKAGHINQDLTRYELHRVWKVEATLKDGARHIYAKRTFYLDEDTWQASQIDHYDGRGQLWRVAEAHNVFFYDEMVPWYTIETLYDLQSGRYLALGLDNEETDSYDFGFTREEKDYTPAALRRAGRR
>NZ_CP051183.1|WP_007017920.1|412713_414705_+|DUF1302-domain-containing-protein
MTKITKSLGFKLLPLAVAVTAGNASALQMSIGPVDTTVSTSISYGVAIRTEDPDPSVIARHGTSELVPNASGSTYNFDDGNLNYEKGDIYTNVLKANADLEFNYDNKAGAFFRAKAYYDSAIMDGDPAWKEYTDATKDAAGQGYDLLDAYLWYNFDIGSVPVSARIGRQVISWGESTFIQGGINSINPIDASAARKPGVEVKEVLLPVNLAYASFGLTYELTLEAFYQLEWEKTRIDPCGTFFSTADFVADGCGPVVLGGPAGEKAYLNVRDIELASGAPLGDRSAPIAERMPDADPSDNGQYGIALRWYSEALGDTEFGFYHMNIHSRVPLISGKAANPYTDTDNDGVDDSVTNTNNPAAAFPSYQIQFPEDIKLSGISFNTTTAGGWSLGGEVSLTQDRPVQHNSLELLLAGNLVPSSKMFKQRYDEATGGDLDVNNPAEVAAAKAALAGNAFNGYDLYDIAQAQMTFVKFYDQVMGASRLTFATEIGMTHVLDLRSKDEARYGRSGVYGVGSFDPIAVGNGAFYTCDANDISAGPTTAGSTDGTNGTNGAGGSNENPANCTNDGYVDETSGGIRVRASLDYNNAFFGANLRPKIALGYDMNNGPEPGSQFVDGRIQASLGLDFVYLNRYSGGIAYSMFDGGDYNVTSDRDNVSLNLKVTF
>NZ_CP051183.1|WP_007017919.1|409945_412660_+|hypothetical-protein
MLKKSLLSIAIAASVVGVSGCDISSTTDNNEVDTAPLEIGTPEYIEENRGNISTTYAIFNPSRATPVGLRETPVISDLLFQGDADEDGTDGTIPLTLGDPGLGDEGYNPIFSAAADLDGFSTTAQIDIPFSGALDQTTISTSGTDANVLLIPLDYDDPLTGSLQAGKFKQSGPAAIKASAIAYASGDDNAQSGQGNVLRISPTEPLLPATRYLVVVTNGIHDAYGMPVTGSNTYKALTADFEFLIGDDAETQQKIDLSNNLKQFQSLAEAYADVASLSYDKEDIVYSFTFTTGGTTTVLESMAAPANFVEGAVTGAGAAFNITLPSQYRYIVEEHVDAQRAADGNLDAAGLTAAVGAIYSDGDFAAVLPSLGGSPAEQQAAIGGIVSIHNAIPSPAPRLSDFSSTIDEAGDDGAGDALDLDTLLGVAATSGTGKVANGTIKVPYYGGIPNLGLSPATAAFVLNKWDADDSLETDLGDVLDGAQVSAENQAKFTPRSTNVTRLFPIAKPQGYLEIPVSVVYSTACGGSYTPVIFQHGITSNRSSSFGVAAQLFAANPCYATVAIDLPMHGLTNEDDAGLLGLLSAEGQSDQRHFGLTLNPLTLEPQAMTGTDDQSGSLFIQLLSFQGTRDNMRQAIMDLMNLNASLEFMDFTDGNAGTDFDVSEVHFIGHSLGAILGTGFVAVNNTVGSEAYSNGCTTCNLTLPKITTATLANGGGQVTKLLENSNIGTNLVIPGLAGLGSKAGLDLGQGSSLFELTLQIFQATVDSADPLNFAEKLNATGTPVLAFEIAGNNDNPSDQTVPVDAVDNRLEPALPAPLAGTEPLATALELTGTSADITAGPESVKAIVRFNNGVHSSFAGISNDGEDGSPTTVFNEMMVQLRSFIDSDGASLDVSDTNVVVSSAE
>NZ_CP051183.1|WP_007017918.1|408169_409357_-|thiolase-family-protein
MSKQDSVVIVSGVRTPMGGFQGSLAPLSAPELGSIVIKEAVERAGLKPEDIQEVIMGNVLPAGLKQGPARQAMRKAGLPDATGATTINKLCGSGMKATMFAHDLIKAGTNDVMIAGGMESMTNAPYILPNARSGYRMGHGDQAMDHMFLDGLEDAETGRLMGSFAQEVADKRNISREDMDNYAIQSLTRAKDAIEKGLLKDEIVPVTVKTRRSETVVEHDEQPFNANIDKIPSLRPAFAKDGTITAANASSISDGASALLLMRESEAEARGLKPMARILGHATQSQHPSEFTIAPVGAVENLLKKLEWSASDVDLWEINEAFAMVAMMPIMDLGLDPETVNIFGGACAQGHPVGSTGSRLIVTLMNALKQKGKNKGVAALCIGGGEATAMAIELL
>NZ_CP051183.1|WP_007017917.1|406448_407933_-|SulP-family-inorganic-anion-transporter
MIETMQREWFSNIKNDLLAGTVVALALIPEAIAFSIIAGVDPKVGLYASFCIAVIIAFVGGRPGMISAATGAMALLMVTLVKEHGLQYLLAATLLTGVLQIAAGYLKLGSLMRFVSRSVVTGFVNALAILIFMAQLPELTDVTWHVYAMTAAGLGIIYLFPLIPGIGKSVPSPLVCIVSLTALSMIVGLDIRTVGDMGELPDTLPIFLWPDVPLNLETLMIIAPYSIGLAIVGLLESMMTATIVDDLTDTESDKNRECKGQGIANIGSGLLGGMAGCAMIGQSIINVKSGGRGRLSTFTAGLLLLIMVVFLDEWIGQIPMAALVAVMIMVSIGTFSWESVINLKKHPLSTNIVMVSTVAVVVATHNLALGVFVGVLLASLFFANKISRFMVVKSVNEDNKRVYQVTGQVFFASADKFVDAFDFKEAAEHVILDLSHAHLWDISAVSALDKVVIKFRREGANVEIIGMNEATATVVDKFAIHDDPAEVEKMMAGH
>NZ_CP051183.1|WP_007017916.1|405580_406426_-|universal-stress-protein
MKKITACIDGSALSTSVCDAAAWASKQLNVPLKLLHVLEKTNIPAREDFSGAIGLGSREHLLDELVELDAQRGKIALEHGKHMLEDAEARVREHGVDQVEKQQRHGDLLESLQDLQDENRIFVLGRLGEGHDLNSGAIGAHIERVVRGIQTPLLLNIGEFSAPQNFMIAYDGSQTAQDALKRFADSPLLKGIKGHIVMVGSDKEQATLDNAVDTLKQNGLDIEGHLLNGDVLDALDAFKQNHKIELMVMGAYGHTRLREFFVGSNTSKMIASSKIPLLVLR
>NZ_CP051183.1|WP_007017915.1|404492_405386_+|DMT-family-transporter
MSGKTVNSAILLLIIGNALALISDVFIKLLEPGAPIFQFAFVRCVISVLLLLPLASKLDRDNLFAGFKIHIVRAHVHLVGLLCMVIALAHLPLATANAVFYAAPLLVMVLSAVFFSEKLTPLSVTAVFSGFAGIIVILRPIEFNWAAIAALGSAFTLAISAVMVRRLPKEQSTTHKLFLNYLLILPAAGALAWWEGAAWSTEILLSALGSAVFILGYNMTVLLAYHQVDANQVTSAEYTGLIWAVAIGWVFFAEVPDIWFLVGSLMIVVPLLLIGLQHGRRKQPARGFNGATEQVSV
>NZ_CP051183.1|WP_007017914.1|403442_404384_-|LysR-family-transcriptional-regulator
MKLPPLKALPVFEAVARLNSFSLAADELAVSQSAISHQIKQLETYLGEQLFWRNGRTLSLTDEGRQYLDGISTALLQIERASEQLLGHEESRLRLSVFSSFAVRWLVPRLPDLQRLHPQVELSLEMSIESPVLSDRVADCFITIHKESPAYSYELLYVERLFPVCSQDYWQKMRRELGRESAEAETLPLSTDDISQFPLLSTHSIFDKTAGDWQAWYKAVDASIPKHANVQHFSHMLLALEAARFHQGIVLTNDYMLSTTKDSEDFVRLPCHLVMTGDEFYFAWKTSRRKERGLQLLRKWLLDEAISSGLRSA
>NZ_CP051183.1|WP_168367030.1|402323_403436_+|Fic-family-protein
MQQWIWQKAAWPHFTWSKDQVAEKLNQTEAQLQSLLSKAGALSDEDILLDTLLQNVLSSSAIEEEFLNAESVRSSLAKRLDVSANAPVSDRSEGVAQLMMDVVDNVNEELTLDRLFHWHRWLFPESVYSLAKLRVGQLRGDEPMQVVSGRLDRPVVHFEAPPKSQLVSDLSVFIKWFEESRQDNALPDLVRVALVHFWFITLHPFDDGNGRIARALTDLALGQAYPNSTRLLSLSLSILNDRKGYYEILERCQKSGLDVSEWIQWFLDSVLSSIQHSEKQIERSRFKARFWKQHVHHGLNKEQIKVLNRLLDGGEKGFEHGISASQYQKVAKVSKATATRHLSDLVRRECLQKLPGGGRSTRYHIKGWIL
>NZ_CP051183.1|WP_007017912.1|401554_402022_-|DUF4124-domain-containing-protein
MKYHAVLILLLSFQAHGEVHKCVDPTGAVSYQANPCQSDNNSISYQPQAIETEYKTIPNVTIKQSKPAKKNQKQSTCPFIPSYELRNLRVKDKYKVGMKKQDIRKRLGQPTSMKRNKWTYLGDHVNRIFNFKHGCLTQWKEKWKGKESQISKYRN
>NZ_CP051183.1|WP_007017922.1|416596_419290_+|helix-turn-helix-transcriptional-regulator
MVTIEHSVVKTLEQFDLKVLAMKMQLPSLPLAHVKRTSLIQYLDSQESNVVLVYAAAGYGKSLMFSEYMFSKKHIQESVAWLSLDAKENDERRFLTYLLACLHGVDDQIFNQALEKLLGGEDCEAVFLNIVDAIAQLQRKIHLVLDDCHEIRNEKVLDWIETLVLYTPENLRLYLLSRVCLPFSLSKLRHTNGVVEITENELAFTSDEMQLWFEQAQLVRLNRSEQEQFHSISQGWPVGLTMLKALYDQFEEIDLSRPNTLMQEYFHEQWRPHLSNSQYELCRQIALLKEVSPEYLLAAYQDDAIQDELTNLLNSHKLVMPVAIYQTWVCLHPMLQAYLQWQGLESVKTVYQQACDWLHDNGFQVAAVEMALKAEDKLKAASLLQQTAESILEDQDIAQLLEWRRQIPDDVIIASPRLVIIFSWSLALALQLDDSERLMAQMARIEGVPGTMTDEISGQLFAIRAYIARCRGNIDNAASLAHQALEKLPKRNFVARAVTYFNLSNVCMTQQSLVDARKYNRLSFETARAAGSIHLEMLAIHEHARLEQVKGNLNLAIKLLDEGLHLSHRLDNRMMAPAYGRLLIYKGYMLLLQNQTAQARQLLLKGLGVCKATHDSYVIMAFVLKSQLFRQSGDIEKAFDYLAEAEAQMQRWNIPSFIYMPWLSTVRCNLLIDQGKVDVALSNIKDLYQQAELAPYLLTPEHFPALKGLLDIFYVRAKSIAGQHKDALRLLDQTLESGKLEQHGFTLLFIYLMRALLRYQLGHEDDALHDFRKALTMAEPDECIMPFIEYSAGMGQLYQQLPDQYKHKPFVQAILKNIELTEDASPNKEFAKMRLVLSQREMAVLKLIAEGLSNQEIAERLFISLHTVKTHARRINGKLDVKSRTQAILKAKEVGIL
>NZ_CP051183.1|WP_007017923.1|419393_420569_+|response-regulator-transcription-factor
MDVKHAIYILSSESGFLSETLGKQYPVHRSTDGEKLLSEVGSDCTLLLMDFRQTGYERLDLIESIRSRSELEHVPIAVLFGDDMESSRVKAFELGCDDYIHRSASDDEIALRCEKLIFNRIANEQLQAQVIQANELAFIAMSDTSDLGINIQFLLDVHTCNNMDELGMRLLQAVGSYGLKASLQLRSELGVKNMDPSGMSKDLEATLLWELRNNGRYVDFGKRSVMNYEQVSLLVKNMPVDDDKKYGAVKDNIFSLLQGADARLKALENISQVTDQQQLMKALSKRMQSMMEDIDEGYQGVVKEIADVVEDMSDRINMVIQNLGLHEDQEKALEEIMNYGINKTNNVFSSGLRLDEQFKGVVKELGGFLSSDKVKLNKEQRLKLLNIVEDM
>NZ_CP051183.1|WP_007017924.1|420601_421537_-|LysR-family-transcriptional-regulator
MEQFDLNEIAIFVKVVDAGSFTGAAKSLGLPKSTVSRKITQLEERLGVRLLQRTTRTLSLTDTGSAYYNQCSRIIGDVEEANIAVTEMQSKPKGLLRITAPMLFGSRVLSDMVSEFLQKNPEIQVEMMLTDQQLDLIQEGIDVAFRVGHLADSSLIARPLGEIKTIVCASPEYIKKHGSPNHPSELINHSTLGWSPKGNWEFDSPEQFSAEINPRVRVNDILSMRMLAINGVGIARLPTFLCAEDINEGRLNPVLCDWSYSGVPIHALYASNRHLSVKVRTFVDFIVDGLRQSQPWAVEFDQFINCSALHK
>NZ_CP051183.1|WP_007017925.1|421867_423355_+|aromatic-hydrocarbon-degradation-protein
MISTKNLLRSAIIAAAVAPAVSMASGYKINEQSAAGMGTAHAGRAAMAEDASVVFYNPAAMTQLDKAQISGGFTYINGYGEFEGNGTDVAGNQITGANDSDPFNDGGNFLGEKFIPFFYYANPISDKLAVGLGVYTPFGTETNYDENFVGGGFADETSLISLELQPSIAYKINDQLSIGGGLDIIYMEGTLSKSVDSVPYNQAVNDNIGSGVVLGNPEYQGFEGFYEVTGDDWGVGWNIALHYQLSEKTNLGVTYRSEIDVDLEGDSTFRDNTFALYNNNGTAADPFDDTVTPVPVQPQASKVPLTTPESLTLSVTHQATDKLLLQAGATWTGWSSFQNFDVIATERATPNQADGLDISDISYGDGVTGLDAGYIGHIDERWVDVWAVAVGATYQLNDQIKLRAGYAYDESPVRDEFRTARVPSSDRQWLTFGAGYKVDQNLSFDLAAGYLFMYPMDLSEINKQNDNTPTDSKASVTGEYEIDVFGLALQANYQF
>NZ_CP051183.1|WP_007017926.1|423635_424535_+|hypothetical-protein
MNTDLSTIVKQPMNSVNQQAESLAQLHHNQQLRLKALDLIKALYELVRVIQQHRAATNAALAGNPFFESKTSPLSREINARMKELERQQDNLEELAREEQWQEIKMAWRTVHQQWHQDEVIENFELHSHLVKLVLLYIADLGESAETLIETHFQYQALGHYVFHDLPWFIELLGQIRALGTSTAVTGQLNKDIEMRLQFLLNQMLKQQVTVKQQAQRLSKEALDITSSLIDALLCEPKLERLTQLLNNDLLSGGDIVTTADEFYTLATAIIDAHYKVMNEGLRLLRLSMDKRIQAWVKR
>NZ_CP051183.1|WP_007017927.1|424629_426723_-|TonB-dependent-receptor
MQRRMLATLLLASSLPLQTAYAQEETNKTTAQKDEDVAELNAVQVQGAEVSGPEITTEKLLKVPGAGNDPLKAIEALPGVVLGGFGPFSIPAIRGSSPRDNIYITDFIPVGYVFHNDGNSTYNANLVENFSLKAGAWGPEYSNAIGAVLATKLRDPYREPLTTTLDLSFLRAGAMIEGALSEDSAFYLSYRRSLLEFYVESFIDEDELTFTEVPRNSDYQFKYHWQPTATTNVRLIATGAEDSVGIEFGPENDALETEPALAGGLDADTYYHSQGILVDTLFDNGTSSMFSLSRKEEKTDFVVGTLFDLDAVNYEYRFKNYYNTPLDNGDTLRYGFDLSQTDIDYTAAGLYSPCNDEIGETCDPASLGEPFGPLGEVLTINGAYSFIAYDWFATPLWEITLGLGNSYNDFNEQNIVQPRLSTRYELNPAWTLTAAVGRHSQFIREFRFIADELGNPELEQPDAMHYVVGFEHEIDESLSSKLEVYYKDIDKLVATNPAYTYDPNNTNNPEQPYLNEATGEAYGIEFLLNKNLTDKWYGWFSLAYSQTKRTNEITGKEIDFELDRPWIVNLVASYQKDERTTYGFKWRYQSGSLITPVEGAIPFDEDGNVIAGNPDPETVYIYDPIEGEPNSERLPAYHRLDFRMDYKLSARSDFYFEIINLYNRANVSDYSYNKDYSEREKVESLPTIFSVGAKLVF
>NZ_CP051183.1|WP_040297833.1|426907_427870_-|DUF1722-domain-containing-protein
MMKIQVAISSCLLGEEVRYNGGHKRSRYIESVLSEYFSFTPICPEVGIGMGTPRPPIHLITTSGNNEEGIEAAQVDDHSKRFTQQLKDYAKQQADQIKDVRGYIFMQKSPSCGYTKVKLYHENGNPLDTAQGIYAAEIERLLPLIPKEEAGRLSDPMLRENFITRVMAYNDWKENVEADLSKKALMDFHTRHKYLLMAHHIPSYQNLGRLMADLKAKPLQQIADEYIMEFMSAIKHVANRKKNTNVLQHLQGYVKQHLTSQERQEMTNVIHQYRQGIIPLVAPLTLLNHHIQKHTEQDGYLLQQKYLNPHPYELGLRNAI
>NZ_CP051183.1|WP_007017929.1|428139_428469_+|hypothetical-protein
MSLSNQQSAQVLFQFDSSFDVSYVNYHRGNELADPQLIVTLERDNERQSFAFMHPHFNDVDRNLISAQGIAISSVKLSPFGQNQIEVSDLKDGLVYFTARVVKNITPTA
>NZ_CP051183.1|WP_133308484.1|428541_428955_-|hypothetical-protein
MVFALGAAFVSPLTLAAEGDPIIYELSVSTDSDWTSIKIRDDAEWVNAPPGKTISLNGRDGVKAMTISPKKVYLRAAGRDEITMNLFVESKNSVLGLELCKGRSSSYVWISSEQSVQKNDTKEREYCSKYALVLKLH
>NZ_CP051183.1|WP_007017931.1|429104_430478_-|PhoH-family-protein
MPNRRRTKAYVIDTNVLIHDPTAIYKFEEHHVVIPMTVLEELDKLKLSKSGVSLECRQAIRNIDSVLGEASPEEISEGIALPSATKQHGHLSILMDKPVQQSTLLPNDLNDNKIINSLIFLQQQRPKTQIILVTKDINMRLKARGCGIAAEDYHNTQLVSDIESLTQGFHKYPGSFWETIEKVDTQHEPGRTVHRIARQSMDQEVFTNQYILDDQNFIARVIEVDDQHIKLWDKSKDGLMQNEAWGLVPRDIYQAAALDLLLDEDIDLVTLTGSAGSGKTILALAAAIEMTVAQNRFNRIIATRSIRGLDEDIGFLPGTETEKMEPWLGAITDNLEALHMDDENTHGSIDYILQKVPLQFKSLNYIRGRSFQKSLIIIDESQNLTPHQMKTIITRAGAGSKVVCLGNLAQIDTPYLNATSSGLTYLNERFKGFSLGGSIELQGVPRSALAEYAESHL

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Crispr_ID: NZ_CP051183_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP051183_2

495152-495278

Orphan

Consensus_repeat	Method
ATCAATTGGATGGATTCTCAGTCAAGCTGAGAATGACGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP051183_2

>merge|NZ_CP051183|2|495152-495278|CRISPRCasFinder
ATCAATTGGATGGATTCTCAGTCAAGCTGAGAATGACGACAGCGGTTGTCATCCTCAACTCGATTGAGGATCCATTATTCGGTTTAACATCAATTGGATGGATTCTCAGTCAAGCTGAGAATGACGA

>NZ_CP051183|2|2|495152-495278|CRISPRCasFinder
ATCAATTGGATGGATTCTCAGTCAAGCTGAGAATGACGA	CAGCGGTTGTCATCCTCAACTCGATTGAGGATCCATTATTCGGTTTAAC
ATCAATTGGATGGATTCTCAGTCAAGCTGAGAATGACGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP051183.1\|WP_007018682.1\|494489_494972_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|376515
NZ_CP051183.1\|WP_133308516.1\|500317_500947_+\|LPP20-family-lipoprotein	unknown	unknown	gnl\|CDD\|376738
NZ_CP051183.1\|WP_007018674.1\|486242_486857_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_007018678.1\|491672_492122_-\|GatB/YqeY-domain-containing-protein	unknown	unknown	gnl\|CDD\|370480
NZ_CP051183.1\|WP_007018672.1\|483338_484775_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223650
NZ_CP051183.1\|WP_007018679.1\|492145_492361_-\|30S-ribosomal-protein-S21	unknown	unknown	gnl\|CDD\|234707
NZ_CP051183.1\|WP_007018680.1\|492626_493652_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	unknown	unknown	gnl\|CDD\|236585
NZ_CP051183.1\|WP_007018689.1\|502278_503850_-\|SpoVR-family-protein	unknown	unknown	gnl\|CDD\|236973
NZ_CP051183.1\|WP_083771936.1\|497466_499167_-\|conjugal-transfer-protein-TraF	unknown	unknown	gnl\|CDD\|372693
NZ_CP051183.1\|WP_007018686.1\|499318_500239_+\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|273359
NZ_CP051183.1\|WP_007018681.1\|494047_494470_+\|dihydroneopterin-aldolase	unknown	unknown	gnl\|CDD\|214902
NZ_CP051183.1\|WP_007018676.1\|487615_489436_-\|RNA-polymerase-sigma-factor-RpoD	unknown	unknown	gnl\|CDD\|235549
NZ_CP051183.1\|WP_007018677.1\|489590_491576_-\|DNA-primase	unknown	unknown	gnl\|CDD\|235551
NZ_CP051183.1\|WP_007018691.1\|505167_507090_-\|PrkA-family-serine-protein-kinase	unknown	unknown	gnl\|CDD\|185352
NZ_CP051183.1\|WP_040298154.1\|496056_497304_-\|multifunctional-CCA-addition/repair-protein	unknown	unknown	gnl\|CDD\|182810
NZ_CP051183.1\|WP_007018692.1\|507499_507814_-\|thiosulfate-sulfurtransferase-GlpE	unknown	unknown	gnl\|CDD\|178908
NZ_CP051183.1\|WP_007018690.1\|503846_505139_-\|YeaH/YhbH-family-protein	unknown	unknown	gnl\|CDD\|377280
NZ_CP051183.1\|WP_007018673.1\|485230_486232_+\|acid-phosphatase	unknown	unknown	gnl\|CDD\|376695
NZ_CP051183.1\|WP_007018683.1\|495332_496064_-\|pteridine-reductase	unknown	unknown	gnl\|CDD\|181668
NZ_CP051183.1\|WP_007018688.1\|500977_502186_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379855

Protein	Function_ID	Function_description	E-value
NZ_CP051183.1\|WP_007018682.1\|494489_494972_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|376515	pfam01288, HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK).	1.73453e-43
NZ_CP051183.1\|WP_133308516.1\|500317_500947_+\|LPP20-family-lipoprotein	gnl\|CDD\|376738	pfam02169, LPP20, LPP20 lipoprotein. This family contains the LPP20 lipoprotein, which is a non-essential class of lipoprotein.	5.21113e-10
NZ_CP051183.1\|WP_007018692.1\|507499_507814_-\|thiosulfate-sulfurtransferase-GlpE	gnl\|CDD\|178908	PRK00162, glpE, thiosulfate sulfurtransferase GlpE.	6.17139e-40
NZ_CP051183.1\|WP_007018678.1\|491672_492122_-\|GatB/YqeY-domain-containing-protein	gnl\|CDD\|370480	pfam09424, YqeY, Yqey-like protein. The function of this domain found in the YqeY protein is uncertain.	5.45674e-55
NZ_CP051183.1\|WP_007018672.1\|483338_484775_+\|ABC-transporter-permease	gnl\|CDD\|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	4.11545e-13
NZ_CP051183.1\|WP_007018679.1\|492145_492361_-\|30S-ribosomal-protein-S21	gnl\|CDD\|234707	PRK00270, rpsU, 30S ribosomal protein S21; Reviewed.	1.87708e-15
NZ_CP051183.1\|WP_007018680.1\|492626_493652_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	gnl\|CDD\|236585	PRK09604, PRK09604, tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD.	0
NZ_CP051183.1\|WP_007018689.1\|502278_503850_-\|SpoVR-family-protein	gnl\|CDD\|236973	PRK11767, PRK11767, SpoVR family protein; Provisional.	0
NZ_CP051183.1\|WP_083771936.1\|497466_499167_-\|conjugal-transfer-protein-TraF	gnl\|CDD\|372693	pfam13729, TraF_2, F plasmid transfer operon, TraF, protein.	2.97722e-22
NZ_CP051183.1\|WP_007018686.1\|499318_500239_+\|EamA-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	6.05532e-11
NZ_CP051183.1\|WP_007018681.1\|494047_494470_+\|dihydroneopterin-aldolase	gnl\|CDD\|214902	smart00905, FolB, Dihydroneopterin aldolase. Dihydroneopterin aldolase catalyses the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate. In the opportunistic pathogen Pneumocystis carinii, dihydroneopterin aldolase function is expressed as the N-terminal portion of the multifunctional folic acid synthesis protein (Fas). This region encompasses two domains, FasA and FasB, which are 27% amino acid identical. FasA and FasB also share significant amino acid sequence similarity with bacterial dihydroneopterin aldolases. This region consists of two tandem sequences each homologous to folB and which form tetramers.	2.77615e-43
NZ_CP051183.1\|WP_007018676.1\|487615_489436_-\|RNA-polymerase-sigma-factor-RpoD	gnl\|CDD\|235549	PRK05658, PRK05658, RNA polymerase sigma factor RpoD; Validated.	0
NZ_CP051183.1\|WP_007018677.1\|489590_491576_-\|DNA-primase	gnl\|CDD\|235551	PRK05667, dnaG, DNA primase; Validated.	0
NZ_CP051183.1\|WP_007018691.1\|505167_507090_-\|PrkA-family-serine-protein-kinase	gnl\|CDD\|185352	PRK15455, PRK15455, PrkA family serine protein kinase; Provisional.	0
NZ_CP051183.1\|WP_040298154.1\|496056_497304_-\|multifunctional-CCA-addition/repair-protein	gnl\|CDD\|182810	PRK10885, cca, multifunctional CCA addition/repair protein.	0
NZ_CP051183.1\|WP_007018690.1\|503846_505139_-\|YeaH/YhbH-family-protein	gnl\|CDD\|377280	pfam04285, DUF444, Protein of unknown function (DUF444). Bacterial protein of unknown function. One family member is predicted to contain a von Willebrand factor (vWF) type A domain (Smart:VWA).	0
NZ_CP051183.1\|WP_007018673.1\|485230_486232_+\|acid-phosphatase	gnl\|CDD\|376695	pfam01975, SurE, Survival protein SurE. E. coli cells with the surE gene disrupted are found to survive poorly in stationary phase. It is suggested that SurE may be involved in stress response. Yeast also contains a member of the family. Yarrowia lipolytica PHO2 can complement a mutation in acid phosphatase, suggesting that members of this family could be phosphatases.	2.77985e-32
NZ_CP051183.1\|WP_007018683.1\|495332_496064_-\|pteridine-reductase	gnl\|CDD\|181668	PRK09135, PRK09135, pteridine reductase; Provisional.	6.30769e-98
NZ_CP051183.1\|WP_007018688.1\|500977_502186_+\|hypothetical-protein	gnl\|CDD\|379855	pfam16539, FlgT_M, Flagellar assembly protein T, middle domain. FlgT_M is the middle region of a family of flagellar proteins that make up part of the basal body of the flagellum. The flagellum is a large macromolecular assembly composed of three major parts: the basal body, the hook, and the filament. The basal body has two unique ring structures, the T ring and the H ring. FlgT is required to form and stabilize both ring structures. FlgT-N and FlgT-M are thought to be involved in the H-ring and the T-ring formation, respectively. and FlgT-M is also required for the stable association of FlgT with the basal body.	1.62374e-36

>NZ_CP051183.1|WP_007018682.1|494489_494972_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MAVVYVSIGSNIDREKNIKGCLQSLAQTFGGLTLSPIYESEAVGFDGDNFYNLVAKFDTDLSVGELNQALKEIEDEYGRDRSGPRFSGRTLDIDILTYDDLVGTFDGVELPRDEITKNAFVLLPMVDLAPDEKHPELDVTYARLWFFYDKEKQNLWQVEL
>NZ_CP051183.1|WP_007018681.1|494047_494470_+|dihydroneopterin-aldolase
MDKVFINQLTIETIIGIYDWEREIKQRVVLDLEMAWDNKPAAQSENIELALNYKAVCDRLQDFIGNNGFLLVETMAEAVAQLLMHEFNVGWLRLKVTKPDAIPQAHGVGVEIERNEKDKLAADAYLNTYTAKPEVLAAKK
>NZ_CP051183.1|WP_007018680.1|492626_493652_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD
MRVLAIESSCDETGIAIYDSEQGLLSHALYSQIEMHAIYGGVVPELASRDHIRKAIPLIKQVMAEANTTSDDLDGIAYTSGPGLAGALLVGACLARSLAWSWDIPALAVHHMEGHLLAPLLEDPAPEFPFVALLVSGGHTQLVDVQGIGQYEVLGESIDDAAGEAFDKTAKMMDLPYPGGPHISKLAEKGTEGRFKFPRPMTDRPGLDFSFSGLKTFARNTITQCREESGLTEQDKADIALAFEQAAVDTLVIKCRRALKETGRKRLVIAGGVSANRYLRERLQQELKKLDGEVFYPRPEFCTDNGAMIAYAGCQRLMAGQRDGEEIVVHPRWPMDELSAV
>NZ_CP051183.1|WP_007018679.1|492145_492361_-|30S-ribosomal-protein-S21
MPQVKVKENEPFDVALRRFKRSCEKAGVLSEVRRREQFEKPTAERKRKKAAAVKRHQKKVMREQRKMTRLY
>NZ_CP051183.1|WP_007018678.1|491672_492122_-|GatB/YqeY-domain-containing-protein
MSNGLVEELKAAVKDAMRAKDKPRLQTLRTIQAELKRVEVDERIELDDARVLVILDKMTKQRRDSIKQYEEAGRDELAEVEQYEISVIQDFLPEALTEQELAAIVDKAVADSDAAGMQDMGKVMALVKPQVQGRADMGIVSKLVKEKLA
>NZ_CP051183.1|WP_007018677.1|489590_491576_-|DNA-primase
MAGLIPQSFIDDLLHRVNIVDVVDSRIKLKKAGKNHSACCPFHNEKTPSFTVSSDKQFYYCFGCGAKGNAVGFVMEYDNVDFPQAVEMLADSVGMEVPREEVSPQQAKKQEERTNLYELMGSANEFYQRQLRYHDAKQAAVDYLKNRGLSGKAAKFFNIGFAPPGWQNLQDSLANDDESLAAMVTAGLTIKNDQGRHYDRFRNRIIFPIRDVRGRTIGFGARTLGDDKPKYLNSPETPIFNKGQELYGLYECRQIRQPLKRFLIVEGYMDVVALHEFGIHYAVATLGTATSDTHLQKLFKIAPEIVFCFDGDEAGRRAAKRGLELVLPIIEDGQQIRFMFLPEGEDPDSLVRKEGKDGFELRMQDADGLSEFLLQTLKDDIDDPASLEGRARLAKLAAPLIKNIPGIALRSLFWQDLKEHTHIDVDELKQLAESEAKPELAPAPNPMVQSSAASHHHEHYESSYSSYDEEMGESREQPIQSTTSGSQEPRLIRQAIAILLHAPQALETFGDTGFLQEFQGPNTQLLQQMITALRQSPRQDLLGVLSLLNKEVDAEAYRQFKELAEYHNKQEGHLSQQQVAMDCLVQLRLKAAKNIKARMIKKAAQFGGMRQLPEQDMQLYQWAAAIVELDLLQAKLTKAGGKFETLTPQEQEKYRQLTGQS
>NZ_CP051183.1|WP_007018676.1|487615_489436_-|RNA-polymerase-sigma-factor-RpoD
MAVTQQSRLKELIAKGKEQGYLTYAQVNDHLPDDIATPEQVEDIIRMINDIGITVSEVAPDADELNMGEVTTDEAAIEEAAAALAAVETDVGRTTDPVRMYMREMGTVELLTREGEIVIAKRIEEGIREVMAALSYFPGAVRTVLDAVEESMADEEINRLGDVFNGFIDASDDDPEPATPVSAEAAADKDSDDDDDDSSDAPSGPDPEEVKRRMAEIEKQLDKTEKAIEKHGRGSKQADKEGEKLAELFAPIKLSPKYFDDLVGTARDNLDFIRVQERQIMVICTRKAKMKRQEFIKSFQGNEGNDSWIDDLINAGKDYSQIIENHGYDLKRAQKKIRQVKDRVGLEISDIKEINRRVSIGEARARRAKKEMVEANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINKLNRVSRQMLQEMGREATPEELAERMDMPEDKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDVNGHSPIDTATETGLTDATRSVLSGLTARESKVLRMRFGIDMNTDHTLEEVGKQFDVTRERIRQIEAKALRKLRHPSRSDHLRSFLDE
>NZ_CP051183.1|WP_007018674.1|486242_486857_+|hypothetical-protein
MRRILFIVISVAILAGCNDYLLEHQGTYQTAYMVNNQAMLARLSINKFGAVLVVTDALEQSSSVNATITHDMEQLDFAGVSECIDVADRFECTLEGQTITLNKTVPMAGTSLEELAGEYQLLNDYGVATIVVADSGKFSTNINGCELKGRLSIDADALVIKKLKDSCDKKVEFGVAFNSTENSAPESLEVFVSDHVLTGDWVKR
>NZ_CP051183.1|WP_007018673.1|485230_486232_+|acid-phosphatase
MKLSRIIASAIIATGFSLPASALNIILTNDDSWATDNIQILFTELKAAGHDVLMATPCLGQSGKGGAMNVIKEVNVDRSIVDQGQVCVGDTDESVPYDDFVAGTPVMAVLYGIDVLAEETWGQAPDLVISGPNEGNNLGYITNNSGTLGAANIAIARGIPAIAISADDGDAEKAVLVASAVNQLIAELEANRGESEPLLPKFTGLNVNTPEDMANNLGFKFANVGWNASDIGLKFFTDLSKSRIAIHFVALSLLKDGHANNYEEATGIAKYLYKDKPGVSFVRDAELIDDNNENSEGVLVDQGYITISTIEANVQASRAKTALTAIKLHGLTQ
>NZ_CP051183.1|WP_007018672.1|483338_484775_+|ABC-transporter-permease
MMRLFFSTVWQSLLHRPVAIGMTIVSIFMSVYLLIAIEHLRGQSQENFKNTVSGVDLLVGPRGSGTNLLLYSIFQIGYPSVNISWDTYEALSKHPQMDWTIPISLGDSHRGFRVIGTTEDYFKHYRYGRKQNLAFQQQGQNSHEHHDHDHEHDHVEDHQAENQANHLDFHGAVIGAYVAQKLDYQVGHEITLSHGLSEASFHHHDDHPIKIQAILEPTGTPVDKLVLVPLAVIEDIHEPASNKKSAASGESSIQSKASFSAGYLTSKQTKQQIKTPKKEEHDHHGHDHESHDDHDHGSHKTPENITAFMLGLNNKMMTFQLQHYINNYKGEALTATLPGVALTQLWQSMNIMENTLRSIAVLVLIASLIGMSATLLASMDARKQELKIFRTMGAHPRFVFAFILTEGFIITFVGIVLALAAILISIPIANQYLIQYLGMTLSFNFLSLSTGIVLIVILLASLLMSCIPAWNAYRKVLV
>NZ_CP051183.1|WP_007018683.1|495332_496064_-|pteridine-reductase
MSKQFALITGGAHRIGAATAQTLHQAGYDILLHYGKSEEAAKTLQARLNEERSNSCHVYSAQLNMGSLPELITWVNSITDELAVLVNNASAFYPTPWESASPEQWQQLMTVNLQVPFFLTQALLPNLKRAKGNIINLIDIHAERSLEEHPIYSATKAALKSLTLSLAKDMGNKVRANGVSPGAILWPEKDDVSDAVKEEILNKVPMQRLGDVRNIAQTILFLCENDYINGQIINVDGGRTVHS
>NZ_CP051183.1|WP_040298154.1|496056_497304_-|multifunctional-CCA-addition/repair-protein
MKTYLVGGAVRDQLLNIAIKDRDWVVVGSTPEDMQGKGYKQVGADFPVFLHPKTQEEYALARTERKSGKGYQGFTVDFTSDVTLEEDLIRRDLTINAMAQDESGEIIDPFNGRLDIKDKVLRHVSPAFSEDPLRVLRVARFAARFHHLGFTVADETLSLMTELSDSGELATLTAERVWVETQRALSEKSPWIYFQVLKDCHALKACFKELDDLFGVPQPEKHHPEIDTGLHSLMVLEQASLLSTDTEVRFAALVHDLGKGKTPKEEWPRHIGHEKKGLKPIKALCDRLRVPNKHKELALKASEFHTHVHRAFELKPSTVFKVFKQTDALRKPERFEQLLLVCKADSRGRTSFENVPYKQMDYLDYLLRCVQQVDTKTIASSGLKGPEIGAAIEAAYVEAIQQGQKNKSDYECLNE
>NZ_CP051183.1|WP_083771936.1|497466_499167_-|conjugal-transfer-protein-TraF
MPLHTDKIQWIPTLSTMLVIMANISKGTTMHLPNKKLLLGAAISLATLQAQAVPFMPTDARAMGMGGTGVSSAEVASTVQFNPALLSLTRDDDHFGLKIPQISIVVADDDGFIDEVEDFDEESELDNSGLSNVDLLSNVLDESTGPLGLEKLNQALTDLETAVLPAQYEAAETKLEESVNYLDTRLFSKNPNIDPELVVYSEAVANDLDDLNNKALRMNFGANMALAIPSKKFSLALSAGGQGTFSGRVLVSSDDSDILRRYPDATSKYLTAVANLQSTLKDFNDGVGGVSAQDVADAEEAVSDFAYGGPNRPADEGDTIIFENGDLAEGADDGSLNSQVEMVGVAIADLGLTASRVFNIKGHDIAFGVTPKLQKVTVFDYLYDLDGEDENGNEVEFDGDTITENSEEYTEINVDLGAAYQFGAEKQFQAGLVVKNLLGKEFESPRYVESNGTAGTIVEVSPQVRAGISHKTSWTKVAFDLDLMENDPVAFEDPTQYASIGAELNVWRTLQLRAGYRANLAGSDQDVVTAGLGISPLAVHLDIGLMANASDPEKEAGIALEFGVEF
>NZ_CP051183.1|WP_007018686.1|499318_500239_+|EamA-family-transporter
MLPVIAVYAAVVLIWSTTPLAIRLSVDSVDFVQGSALRMWISLALCLLLLPLFRLKLSFNKLAMQRYMASALGICFAMLCVYWSAQTLPSGLIAVLWGLTPILVSLQSRCLIAGTRLDGLRLLSMAIAVLGLYVIFAQQIALSPTMAVALAVLLLAVNFHSLSAVLLQKLQLKQQSSEDERMHPLVQTTGGLLVSAPIYAIVWLLMSGPLPEVMSWTSIGAIAYLSIIGSAVGFIGYFYLLTKMSAADASLITLMTPVIALFLGTSIANETLSDRTLMGAGIILFALFIYHLKNIRLVLVRLAQKD
>NZ_CP051183.1|WP_133308516.1|500317_500947_+|LPP20-family-lipoprotein
MKVVTIAIMLSLTAGCSTISNMFGFGDEEEEKVSDVQHSESMLKPVQTNVDPVAPLILRVVGYGAINPRAKNMSDVQKRLMAIRASRLDAYRSMAERVYGTKLTGSSTVRDLVVKNDNFRTYVDTFIHGARVVSSDVMEDGSVETVLEMVIDAGFRNCLVTENSMRFNSDCRSKVMQNGSNSMRTSRYQNINRIQSQSAIPETNHYFVD
>NZ_CP051183.1|WP_007018688.1|500977_502186_+|hypothetical-protein
MKHWILAIVMMLAAMLITVSSYAVELTSVGSAAVGKDLIESRDNAIRDALRQASLQMGGSIHSSQMLVDGLVTRDQVNLKSNGQFRHVRVLEEKIAHGIIQVKIRAEFLEGGQCETNQGNGYRKAVAVAGFALQNPKDSVLGGLGNIEQRLSGVLANTINGRHRLHAMDSGHVLLFTSVDRAPSSQNNLQRLTNSVELAKELGAQFVVSGVIRDLSMVNPNADLPSIWDTPLSYVGIEKDKRHRNFVLDVYVHDGISGSLMFQNTYATMGEWNYDDHRRTGFATPVYWKSDFGQKSKELISKVVRDLNSNLGCQPYMAKIIDARGDFIRIDTGSSVGMRPGDELTVFRTSTFYNLDQQGLTQLQGTEIKAKITQVQPRFAVAKLEKTAARFAIQREDVVVAW
>NZ_CP051183.1|WP_007018689.1|502278_503850_-|SpoVR-family-protein
MTAAKKSAKKKPYEPISQGSDWNFDLLREYDSHIARIAEGYRLDTYPNQIEVITAEQMMDAYASVGMPISYHHWSYGKQFLQTQTHYQRGQMGLAYEIVINSDPCIAYLMEENTITMQALVIAHACYGHNSFFKGNYLFRTWTDASAIIDYLVFARQYIKECEERHGVDAVEDVLDAAHALMNYGVDRYKRPRPISAHEEKERQKNREDILQQQVNDLWRTIPGKEKVKEEKERRYPQEPQENLLYFLEKNAPLLRPWQREVIRIVRKLAQYFYPQRQTQVMNEGWATFWHYTLLNTMYDEGLVSDGFIMEFLNSHTNVVYQPPYDSPYYSGINPYALGFSMFTDIRRICENPTEEDRRWFPDIAGSDWLDTVHFAMQNFKDESFVLQYLSPKVMRDMRLFSIMDDERKMHIQIDAIHDDEGYHQVRENLARQYDLSYREPNIQVYKVDVEGDRSLTLHHYRQDNVPLGDDSNEVLKHLRRLWGFDVYLHSIDDQGKVAKTYSCTNDKEKPYDVDIQLDLSVP
>NZ_CP051183.1|WP_007018690.1|503846_505139_-|YeaH/YhbH-family-protein
MSYIIDRRLNGKNKSMVNRQRFLRRYKSHIKKAVTDAVNKRSITDMERGEKISIPTRDTNEPTFHHGQGGARQRVLPGNKEFHAGDKILRPKGEGQGGGAGEGNASNQGEGIDDFSFYISKEEFLDYVFEDLALPNMVKKTLTEHDAMEYRRAGYTATGTPNNLAVVKSMRSAQARRIALSASSRRKLRAAKKELGEELEKDEDLRNPIKIKELEERIQKLEEKIQRIPFIDTFDIHYRNLVKEPTPSTKAVMFCVMDVSGSMTQQIKDIAKRFYILLYLFLERNYERTEVVFIRHHTSAKEVNEEEFFYSRETGGTIVSSALELMADIIEARYNPAEWNIYGAQASDGDNWDDDSPQCAEILSQRIMPLLQYFAYIEITPHAHQALWRAYEELAPQLGERFAMEQITGAEEIFPVFRDLFSQKDIKEAV
>NZ_CP051183.1|WP_007018691.1|505167_507090_-|PrkA-family-serine-protein-kinase
MTIFNHYQDRYKVTQEEVMTLQEYLQLCKEDPTAYATAPERMLQAIGEPELINTSDDPRLSRIFSNKVIKRYPAFSEFYGMEEAVEQIVSYFRHAAQGLEERKQILYLLGPVGGGKSSLAERLKHLVQKVPFYAIQGSPVFESPLGLFDPDEDATILEEDYGIPKRYVRGIMSPWAAKRLREFKGDISQFKVVKLYPSIIDQIAVAKTEPGDENNQDISSLVGKVDIRQLEDHSQDDPDAYSFSGALCRANQGMMEFVEMFKAPIKVLHPLLTATQEGNYNGTEGMGAIPFDGIVMAHSNESEWQTFKNNKTNEAFIDRVYIVKVPYCLRIKEEMQIYEKLLKNSSLNRAPCAPDTLHMLAQFSILSRVKEPENSSVYSKMRIYDGENLKDTDPKAKSIQEYRDAAGVNEGMSGLSTRFAFKILSRVFNFDASEVAANPVHLMYVLEKQIEQEQFPQETADRYLNFIKEYLAPKYVDFIGKEIQTAYLESYSEYGQNIFDRYVTYADFWIQDQEYRDPETGEILDRAAINEELEKIEKPAGISNPKDFRNEVVNFVLRAKANNQGKNPSWQSYEKMRSVIEKKMFANTEDLLPVISFNAKGSSDEKKKHDNFVARMVERGYTEKQVRLLSEWYLRVRKSQ
>NZ_CP051183.1|WP_007018692.1|507499_507814_-|thiosulfate-sulfurtransferase-GlpE
MFKHMNIAELRDIMDSEAVKIVDIRDLISFQQGHIPSSLRLDNDNVQQFITDTPKDSKVVVCCYHGNSSQSAAQFLAEQGFSDVYSLDGGFTMWQSLYPDRVSS

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Crispr_ID: NZ_CP051183_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP051183_3

535285-535435

Orphan

Consensus_repeat	Method
GAATATTAAAACCCAGACTTCGCAAGAGATCTGGGTTTTTTCGTTATGGGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP051183_3

>merge|NZ_CP051183|3|535285-535435|CRISPRCasFinder
GAATATTAAAACCCAGACTTCGCAAGAGATCTGGGTTTTTTCGTTATGGGACTGTGTCCCAGGTTCACTGTTTGGGTATCTGGCGGTGTAGCCACCAACGAATATTAAAACCCAGACTTCGCAAGAGATCTGGGTTTTTTCGTTCTGGGAC

>NZ_CP051183|3|3|535285-535435|CRISPRCasFinder
GAATATTAAAACCCAGACTTCGCAAGAGATCTGGGTTTTTTCGTTATGGGAC	TGTGTCCCAGGTTCACTGTTTGGGTATCTGGCGGTGTAGCCACCAAC
GAATATTAAAACCCAGACTTCGCAAGAGATCTGGGTTTTTTCGTTCTGGGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP051183.1\|WP_007018715.1\|530728_531259_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NZ_CP051183.1\|WP_040298101.1\|526703_528074_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP051183.1\|WP_133308511.1\|531248_532076_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_007018725.1\|539028_540621_-\|cation:proton-antiporter	unknown	unknown	gnl\|CDD\|226998
NZ_CP051183.1\|WP_007018709.1\|524364_526692_-\|FecR-domain-containing-protein	unknown	unknown	gnl\|CDD\|377406
NZ_CP051183.1\|WP_007018711.1\|528115_528700_+\|cyclic-nucleotide-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|237999
NZ_CP051183.1\|WP_040298104.1\|534255_534999_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_133308512.1\|536239_537364_-\|sensor-domain-containing-diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_CP051183.1\|WP_007018714.1\|530474_530711_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_165837043.1\|541727_541973_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_007018718.1\|533378_534110_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_165837044.1\|541981_542134_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|225110
NZ_CP051183.1\|WP_007018730.1\|544482_545454_-\|NADPH:quinone-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|176203
NZ_CP051183.1\|WP_007018724.1\|538150_539032_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182768
NZ_CP051183.1\|WP_007018713.1\|529107_530304_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|367519
NZ_CP051183.1\|WP_007018726.1\|540764_541535_+\|ferredoxin--NADP-reductase	unknown	unknown	gnl\|CDD\|99792
NZ_CP051183.1\|WP_007018721.1\|535604_536234_+\|cyclic-nucleotide-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|237999
NZ_CP051183.1\|WP_007018717.1\|532231_533128_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_007018723.1\|537494_538043_-\|DUF1415-domain-containing-protein	unknown	unknown	gnl\|CDD\|377792
NZ_CP051183.1\|WP_007018729.1\|542112_544407_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|236645

Protein	Function_ID	Function_description	E-value
NZ_CP051183.1\|WP_007018711.1\|528115_528700_+\|cyclic-nucleotide-binding-domain-containing-protein	gnl\|CDD\|237999	cd00038, CAP_ED, effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels.	8.92456e-18
NZ_CP051183.1\|WP_040298101.1\|526703_528074_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.2937e-07
NZ_CP051183.1\|WP_007018730.1\|544482_545454_-\|NADPH:quinone-oxidoreductase-family-protein	gnl\|CDD\|176203	cd08241, QOR1, Quinone oxidoreductase (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	8.30224e-155
NZ_CP051183.1\|WP_007018725.1\|539028_540621_-\|cation:proton-antiporter	gnl\|CDD\|226998	COG4651, RosB, Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism].	1.41977e-56
NZ_CP051183.1\|WP_007018709.1\|524364_526692_-\|FecR-domain-containing-protein	gnl\|CDD\|377406	pfam04773, FecR, FecR protein. FecR is involved in regulation of iron dicitrate transport. In the absence of citrate FecR inactivates FecI. FecR is probably a sensor that recognizes iron dicitrate in the periplasm.	8.67347e-14
NZ_CP051183.1\|WP_007018715.1\|530728_531259_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	0.000298054
NZ_CP051183.1\|WP_007018726.1\|540764_541535_+\|ferredoxin--NADP-reductase	gnl\|CDD\|99792	cd06195, FNR1, Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently bound FAD as a prosthetic group) are present in chloroplasts, mitochondria, and bacteria in which they participate in a wide variety of redox metabolic pathways. The C-terminal domain contains most of the NADP(H) binding residues and the N-terminal domain interacts non-covalently with the isoalloxazine rings of the flavin molecule which lies largely in a large gap betweed the two domains. Ferredoxin-NADP+ reductase first accepts one electron from reduced ferredoxin to form a flavin semiquinone intermediate. The enzyme then accepts a second electron to form FADH2 which then transfers two electrons and a proton to NADP+ to form NADPH.	5.83337e-112
NZ_CP051183.1\|WP_007018713.1\|529107_530304_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|367519	pfam03486, HI0933_like, HI0933-like protein.	0
NZ_CP051183.1\|WP_165837044.1\|541981_542134_-\|EAL-domain-containing-protein	gnl\|CDD\|225110	COG2200, Rtn, c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms].	6.23068e-22
NZ_CP051183.1\|WP_007018724.1\|538150_539032_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|182768	PRK10837, PRK10837, putative DNA-binding transcriptional regulator; Provisional.	3.01335e-95
NZ_CP051183.1\|WP_133308512.1\|536239_537364_-\|sensor-domain-containing-diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	2.93687e-63
NZ_CP051183.1\|WP_007018729.1\|542112_544407_-\|diguanylate-cyclase	gnl\|CDD\|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	1.2118e-88
NZ_CP051183.1\|WP_007018721.1\|535604_536234_+\|cyclic-nucleotide-binding-domain-containing-protein	gnl\|CDD\|237999	cd00038, CAP_ED, effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels.	4.07161e-18
NZ_CP051183.1\|WP_007018723.1\|537494_538043_-\|DUF1415-domain-containing-protein	gnl\|CDD\|377792	pfam07209, DUF1415, Protein of unknown function (DUF1415). This family consists of several hypothetical bacterial proteins of around 180 residues in length. The function of this family is unknown.	1.54742e-75

>NZ_CP051183.1|WP_040298104.1|534255_534999_+|hypothetical-protein
MKGTMRYILLIPVLLFSLNAFSLSPLNQHTLAVGQGMSAFYMFSLSEGDQRYQQQYQQHFQAASEYLDELTEFDTMLAGELRPLWQDLKGKLKYEVIPGAGYTMSTRTRVEFRDYLTLLYTKVHQQVSSESQLHNELYLMAIDVEMMTARFFDISSSEYGVMGLSASQRAIDPLRMANAFNRQLRKLEKMGIPRNLKRQLERVETKWRFIEDSVVNYKDEAAFLTVFFNKKQIGKILTESTDLIAAT
>NZ_CP051183.1|WP_007018718.1|533378_534110_+|hypothetical-protein
MRILLCAIIFCLSFSAYSNEYLLRHIVATSQAMSSLYMKGLSQGSNRYEKDFVQYRQNAQANLQMLQQEDNKLFQDLSERWQLFSDKLALTYSEEYGWDIDSAIRRDFRGYLSNTYEIARERAQTFDSEILKRLYASVQVEAMVARFLDIASTYNGTFSLSLSDAEKLDIQQANEIFKSTLEELKGQSSAEKNMQTAARKWEFVEKNVIGEASQGAFFLVYATKTRITNILIPSLNTTVSSDF
>NZ_CP051183.1|WP_007018717.1|532231_533128_-|hypothetical-protein
MNTKTGLIGLMVAAFLSLTGCGSDDEGNPYSFELELGTVENGVAEVTVSVELTDGTALPNEQIQVSPLMIMTNSVEHGTPFESTTGTLDENGSYTATAYFLMPSNMPSGDPMGDWYIDVTYDGQMQTFPITVEMNSGDVKQLRGGANDQIMSMNGGTVSRNYYVYNRGRHIHEAMGMNNFEVYVAARESMMDYQAVAEGNVLNADSMYELDIASVVVEMCIESCDNETNWKTAMADVENKGVYKGMNLGLAGDETDIINVRLSVNNDQKDNGDSSNPETTVTFTFDGAVDDSMMHPNH
>NZ_CP051183.1|WP_133308511.1|531248_532076_-|hypothetical-protein
MLDISTGYVHYDGFWDATGNKKQDPANTTLTQQTLNTSYAMRLAEQWQANVYIPLTVNKSEYGDSTEQQTGLGDVQFGIWYEAFERVTCVYKITGWQSLKPSIYFGSQLTLPTGYSQHSDDVESNFDITGRGFYRWDISTIIEKTIYPWTLSYQYTHGYHVERPVNQEYSNPVDPYNKQLGATNSWSLGGGYTWFLPDYSMLSLTITHAEMKERDTQINNQRISDTGFSESRLSASLVWNSTSRDWLVKTSFSEAQAGSNYSKTQIVNIGASYVF
>NZ_CP051183.1|WP_007018715.1|530728_531259_-|thioredoxin-family-protein
MFSKFTFRCVLLLFLIASTACMEDLTPSNDPIQGEQNRQGLQGTVLEDIALIDNNLNKWQLSQALSEADAVAFYFTMWCPVCDSHMQHIKNHLAEDYPNVTFVFVDYVSSSQAMSRETQIASGYQSSQVLADIDSELQNNLSASMSSFAIIDKNFVVRYNQVFQSDTGIRDVLDSF
>NZ_CP051183.1|WP_007018714.1|530474_530711_+|hypothetical-protein
MRCPFCRENVVGKKSIVILAGEGPAHKHCYESHTYQSRQFDNIDLQKLDDTKLFELKDLVLMEINSRQEQEPEIELFA
>NZ_CP051183.1|WP_007018713.1|529107_530304_-|NAD(P)/FAD-dependent-oxidoreductase
MSNNHAVIIGAGAAGLMCAISAAESGVDVLVIDHANKAGKKILISGGGRCNFTNMYTEPSNYLSQNPHFCKSALKRYTQWDFIAEVDRVGLPWHEKKLGQLFSDNKSQAILDMLLNRCDELGVTIRLNCTMETVSQQENGFILNTNQGVIECHALVVASGAMSFPTMGATDFGHKLAKKFGLNITETRPGLVPFTLDARDLAPLKNLSGVAIDAMVSCRDMSFRENILFTHKGLSGPAILQISSYWKPGQSVTVCMLPDIDLAQFFKDAQQNQPNKQLNTVLRQHFPERLIEAFCQDFDLSKPLQQYKHKDLTSIAERFQNWQFIPSGTEGYKKAEVTLGGVDTDEVSSKTFEAKSVKGLYFIGEVLDVTGHLGGFNFQWAWASGHCCGKAIADSMTA
>NZ_CP051183.1|WP_007018711.1|528115_528700_+|cyclic-nucleotide-binding-domain-containing-protein
MIIKNAGWATLNERLILEGAITGLRAGLGMKKINSLTRGKMLIILNKVPFFKEFSSFERERIVDNNAAFYVANEDEFIIEQGTLDTAFYILMSGTARVVLDGRNEILAEMHPGEFFGEIAFIQNVPRSSHVIANETCIMLKVDRRLLGALNSDIREKFKDQIIYKLANMITKNNEAPKETPSQNRPNQAPFQET
>NZ_CP051183.1|WP_040298101.1|526703_528074_-|tetratricopeptide-repeat-protein
MLKSSLIMSFNSSLVLTLFFMLMVAHPSNAQDSTPDIQETEKQLKQLELLVNARQFDQAYSLASSIRNNEEGRPSFDFYYGLAAIETGHFDEALFAFERLLFYQPNNPRYRLELARVHFYLRNLKRSESEFKQVLKQNPPAPVRNNVKTFLDKIAELYRQVEPEFMLALDLAGGYDSNINSATSEDELPQEELIFPVDIVLSEDAKETASAYWSTLIHFAYLRPISKTQSLDVRAIYNKRANSETSLYDLDTLIAEGAYGFFTGPIRWRLTGRYQSVLLDSESFLSTLSFLGNGRWRQPNGASYGIGFNLGQSEYDDNPNGDIQQMQYKFTYQSPPKKSNWTISAFFGLDDAKESINKYNGKSYQGFSVQQTTLHTQRSSYYWMINITASEYDAINTALYSKLREDISLHSTLGWRYNITSKLSFRNDYSASYQDSSLEANTYQRFKAELGITYRM
>NZ_CP051183.1|WP_007018709.1|524364_526692_-|FecR-domain-containing-protein
MKVFIFIFFSLFLSIPSFSADIAARVIIAKGTVIAQNDTESRALKRRSEIYRGEIIRTGPNSSVQLRFIDKALMTIKANSELDIEEYVLKSETTASDKALLKLVKGGFRTITGSIGKGDKDAYKVSTPAASIGIRGTAYEVQQEANDSFVVGVYEGGIRVENESGSIDLGLGADYNYSRVTPNTAPKGLLAPPTAFGLNSATNKPVEGDEEENSNETEQSSDESDTELAENQEQDGQEEDADFTDSLLSDNDNEFLADIDQVIVDAVDTKLAETIEASTSSEFDFNNPYAGVNISNSSNPFAENIISDEAYALGESGKLGLVAIPSMFNFFGSGETPTIPLMEAQLESFNTMTDASIETVTYAQGSTVEIRYSILEKSGTNGDYVTRHFQYEIPIAESSNTTVTNSDDLNNIFQFTSGILYEETNNGRIVSSDPIHINIYNAATTGEFRLQIATATSDPTQAFLSSLELDIFGVNEETEQKFYQQIGSQQLADGSYSDQDWYTQAELEVFIGNGSWDPKNNQPILVENEEEQDGTTRIAIIKKDNEDNQVIDSYLAYTSASPSCGGAESSLEPCDIQVKDVGGRDNIRWGVWISEPDEPITITDIDNGSAFTEEESNILAFWIAAERADINQLSGTASFTANDLDCTDLTQCMGFADDGVVTSLSGNFSVDFNNSRISQGSINLDVSDSVNGSIVSQWDVSFQNAQIKGADFHTNQIQGSVKDSAGTEISSHIVGNIGGIFVKPGDKAVGGYNFGALDTEGIHKHATGVFQLDKQ
>NZ_CP051183.1|WP_007018721.1|535604_536234_+|cyclic-nucleotide-binding-domain-containing-protein
MQKVSREDYNTEALMRLVRSVTFFKDIYQLEPSQFELLLSVCDFVQAPSGDVVLRKGDEANTLYFLLKGQMSVFNEEQGESLNLINPGEVFGTLSMVTGRPRSATVKAESNVILLGMDFKHFNAIDDFSMFTMDTKLVAYRMVVHNVRWTLEMNKMRDPNHPFVARLLKAPVFRGEKGGKEELLSLQEQAQYLAELLGDWNECLESPAH
>NZ_CP051183.1|WP_133308512.1|536239_537364_-|sensor-domain-containing-diguanylate-cyclase
MEARLLKRTDMDFLQRSIPGVLIYAFMWPMLAWGMEFNDRAPTFSYTFSTLFIVTSILRLAHGILTQPFYAANPNAWRMTMYVLAFIHSCTLALLFILVLIIPEYRDLAMAVALIVVGLLSGASASLSPKPIFTQFYIGSLAFPATLVSFLVEEFRFLSPLFAATWIYFIFLGRRFYNEYQRAFHIEMRLKENQVKLERLNETDTLTGIYNRQYFDNALDMQWDLASRSENSLSILFLDLDHFKKINDNFGHLAGDQVLCHAAHLFSEIARRKTDMIARYGGEEFAIILPATEKQDALDLAEQIRHAIENTPCRSDQGLIHLTVSIGVNSVVPSPQGSPVTFLDQADQALYQAKNNGRNQIMFAAAQAGSTSLD
>NZ_CP051183.1|WP_007018723.1|537494_538043_-|DUF1415-domain-containing-protein
MSIETDIWQWLDNVVIDLNLCPFARKPRKAKQIRLALFTDRDLSQLDQFLLQELEYLMQTPSQTVETTLIATPYCLAVFEDYLDYLDQAQWLLERAGLEGIIQIASFHPNYQFSETQADDPSNLTNVAPYPILHLIREDSLEEVLKRYPDPEQIPENNIKLMKSLTQEDKARLFPYRAPLKS
>NZ_CP051183.1|WP_007018724.1|538150_539032_-|LysR-family-transcriptional-regulator
MRFSLRQLEVFLATAHYQNISKAADSLAMSQSAASSALKELEQQFDVLLFDRVGKRLQLNEQGRLIRSRAEALLEQAKEVESALMQHQEAGVVKVGATLTIGNYLAVNILGDLLQVHADAQVELSVANTQSIVQQVLNYDIDLGMIEGEIQHSELDIIPWREDDLCVFCAPHHPLAKKTLLSDEDIKNSHWILRESGSGTRQAFDRAMHGILPELNIMLELQHTEAIKRAVGKNLGVGCLSRIALEDAFKRGDLVELPVPQRDFIRTLYFILHKKKHRSAGIERWLAFCQRAS
>NZ_CP051183.1|WP_007018725.1|539028_540621_-|cation:proton-antiporter
MEFIWIVIAFACGFIAKQVNMPPLVGYLLAGFGLHAYGVEPHDNLETLANLGITLMLFTIGLKINIRSLLKPTVWAGSVIHMSSWVVVGSLLLKGFAMFGVTMLEGLSGESLLLIAFALSFSSTVCVVKLLEDKTEMKANHGKLAVGILIMQDIVAVGFLVLATGKIPDVYALALLLLWPARKPLGLLLTKAGHGELLPLVGLLLAFGGYELFNAVNLKGDLGALIAGLMLSQHTKANELAKSLLNFKDIFLIGFFLNIGFAALPTVDMLMPLLVISFILIIKGVLLFHILALLKAPGRSMFLGSMILTNYSEFGLIVMYLCVENSWISNEWLVIVAMAVSISFVFTSIFYEYAHRAYAFMRIYVKRFERQRPKPLYHEQLKQAEVLVIGMGRVGRSSYDVLHHYLGDKVWGVESDADKARRHQDAGRHVIIGDAEDADFWETRELWHIKLIMLAMPSITDMKDITQQLKLCNFTGQVAAIARYEDERRALVDYGVDNVFNHYAEVGAGFAEECLTLIAPESKSQQEVSP
>NZ_CP051183.1|WP_007018726.1|540764_541535_+|ferredoxin--NADP-reductase
MKGFNTETVTSVHHWNQDLFSFKVTRDAGLRFKNGHFIMIGLQVEDKPLMRAYSIASANYEDELEFFSIKVPNGPLTSRLQKIQPGDEILISKKPTGTLLVDDLLPGKHLYLLSTGTGLAPFMSVIRDPYTYEKYDKVILTHGVRYQSDLAYKDYIENHLPNHEYLGELVQEKLLYYPTVTREEADFTGRLTDAMESGKLYDDLGLPLPNKQDDRFMLCGSPSMLKDLTSILDKQGFAETRHGNLAEYVIERAFVE
>NZ_CP051183.1|WP_165837043.1|541727_541973_+|hypothetical-protein
MTAVEGKVVFDKGRYLVADTPIVGMSLQDMRKYEERQVKIQGVERESGEIEVYKISVKTDTGYQTTYDWDIVDQTYYGPGL
>NZ_CP051183.1|WP_165837044.1|541981_542134_-|EAL-domain-containing-protein
MAHKLGMKVIAEGIETEQQKQLLINSGCDFGQGYLFSKPVSAEEFEKLLS
>NZ_CP051183.1|WP_007018729.1|542112_544407_-|diguanylate-cyclase
MTSLRPWQYDLMEQSPQPCAVRGEGDDIVYINPAFTLVFGYTLDEVRNINTWYRCAYPDESYRRSVLQDWEQQLRQLEQTNSHPVHLEVTIQCKNGEKKRVELYPFKLNDGQHCQYGINFIDVTRARKAEDAVKKSEERHRLAMKSSGTRIWDWDVKQQKFYFSPDLVEELGYDGQRLEYNVDDFYNIVHPDDLKAIEKAIRQHFKYNTPYHLNYRLRHKDGHYFLYENIGQAIRNQDNLVQRFIGSSKNLSTQKALNEQAQFGRLVFDNSGEGILIADAHRVIKAVNSAYCYISGYEQHEVIGLESDFLLKENPLDEKQRDIFKSIQRNGYWRGETWYKHKEGHAIAIEMMINTQKNSNNEIENYIVLFSDITDKKQTQELIWQQAHYDNLTQLLNRHSFTQYTQNLIQKALPFALLFIDLDNFKQVNDTQGHNVGDALLIEAAKRIKQCVRESDIVARFGGDEFTVLLLGIKNVLSTKRICSDITKRLSEPFTLDKEKAYVSASIGIAQFPWDSDNLEDLYKYADQAMYEAKHLGRNRFSFFTHELQQKASERQRISLDLRQALERNEFQVYYQPIVDLKSHQVHKAEALIRWHHPRDGIISPADFIPIAEESGLIIEIGNWIFKQAAMQTKLWRKTLYPDFQISINKSPVQFYGNQEDIHQSWSQFLQIINLPGDGISVEITEGLLLDSIPIVKEKLSDFSQSGIQVSLDDFGTGYSALSYLKKFNIDYIKIDMSFVRNIVNDKYDLILCETIIAWHINSV
>NZ_CP051183.1|WP_007018730.1|544482_545454_-|NADPH:quinone-oxidoreductase-family-protein
MKQVICKEFAPIDSLTIADVDSPEPKKNQVRIKAEAMGVNFPDGLLVQGLYQMKPPTPFVPGIEVAGTIDAVGEGVDELNIGDSVAVLMPIGGYSEEVVVHKAMVQPLPNGVSPAHATALMCAYGTSHHALKQRANLQAGETLLVLGAGGSTGIAAVEIGKAMGAHVIAVASSDDKLELAKQHGADELVKNDDHLADNLKALVKNKGIDVIFDPIGGDAFDTCIRRMAWNGRYLVIGFASGRIPELSVNLALVKGFSLMGVFWGTFVQKQPQDYMTNQQELFQWYKEGKVSPHIHASYPLEQVKDALNAVLSGKVLGKVVLTP

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Crispr_ID: NZ_CP051183_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP051183_4

1015147-1015264

Orphan

Consensus_repeat	Method
TGATTCAAGACACCGTCATTCCCAACTTGATTGGGAATCCATTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP051183_4

>merge|NZ_CP051183|4|1015147-1015264|CRISPRCasFinder
TGATTCAAGACACCGTCATTCCCAACTTGATTGGGAATCCATTTTGAAATGTTGAATGCCTAATGGCGACTGATGATTCAAGACACCGTCATTCCCAACTTGATTGGGAATCCATTTT

>NZ_CP051183|4|4|1015147-1015264|CRISPRCasFinder
TGATTCAAGACACCGTCATTCCCAACTTGATTGGGAATCCATTTT	GAAATGTTGAATGCCTAATGGCGACTGA
TGATTCAAGACACCGTCATTCCCAACTTGATTGGGAATCCATTTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP051183.1\|WP_007019041.1\|1007207_1007699_-\|DUF4442-domain-containing-protein	unknown	unknown	gnl\|CDD\|373120
NZ_CP051183.1\|WP_007019059.1\|1025110_1025899_-\|META-domain-containing-protein	unknown	unknown	gnl\|CDD\|377235
NZ_CP051183.1\|WP_007019049.1\|1012402_1013188_-\|crotonase/enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl\|CDD\|180625
NZ_CP051183.1\|WP_007019058.1\|1024488_1025106_-\|trimeric-intracellular-cation-channel-family-protein	unknown	unknown	gnl\|CDD\|225415
NZ_CP051183.1\|WP_007019057.1\|1023138_1024395_-\|diaminobutyrate--2-oxoglutarate-transaminase	unknown	unknown	gnl\|CDD\|236437
NZ_CP051183.1\|WP_007019050.1\|1013206_1014997_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173842
NZ_CP051183.1\|WP_007019052.1\|1016405_1017239_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225543
NZ_CP051183.1\|WP_007019043.1\|1008290_1008890_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_007019042.1\|1007799_1008252_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_CP051183.1\|WP_007019051.1\|1015307_1016330_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|227311
NZ_CP051183.1\|WP_007019045.1\|1009838_1010723_-\|folate-binding-protein-YgfZ	unknown	unknown	gnl\|CDD\|223431
NZ_CP051183.1\|WP_040298256.1\|1011573_1012239_+\|thiopurine-S-methyltransferase	unknown	unknown	gnl\|CDD\|213871
NZ_CP051183.1\|WP_007019056.1\|1019773_1022884_+\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|226220
NZ_CP051183.1\|WP_007019055.1\|1018254_1019781_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|379862
NZ_CP051183.1\|WP_133308531.1\|1011355_1011568_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_007019044.1\|1008978_1009806_-\|HDOD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224554
NZ_CP051183.1\|WP_040298255.1\|1010861_1011125_+\|succinate-dehydrogenase-assembly-factor-2	unknown	unknown	gnl\|CDD\|225489
NZ_CP051183.1\|WP_007019060.1\|1025902_1026349_-\|DUF1851-domain-containing-protein	unknown	unknown	gnl\|CDD\|370180
NZ_CP051183.1\|WP_007019053.1\|1017269_1017683_+\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|181730
NZ_CP051183.1\|WP_007019054.1\|1017755_1018196_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP051183.1\|WP_007019041.1\|1007207_1007699_-\|DUF4442-domain-containing-protein	gnl\|CDD\|373120	pfam14539, DUF4442, Domain of unknown function (DUF4442). This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 139 and 165 amino acids in length. There is a conserved PYF sequence motif. There is a single completely conserved residue N that may be functionally important.	1.22138e-38
NZ_CP051183.1\|WP_007019059.1\|1025110_1025899_-\|META-domain-containing-protein	gnl\|CDD\|377235	pfam04170, NlpE, NlpE N-terminal domain. This family represents a bacterial outer membrane lipoprotein that is necessary for signalling by the Cpx pathway. This pathway responds to cell envelope disturbances and increases the expression of periplasmic protein folding and degradation factors. While the molecular function of the NlpE protein is unknown, it may be involved in detecting bacterial adhesion to abiotic surfaces. In Escherichia coli and Salmonella typhi, NlpE is also known to confer copper tolerance in copper-sensitive strains of Escherichia coli, and may be involved in copper efflux and delivery of copper to copper-dependent enzymes.	5.33594e-22
NZ_CP051183.1\|WP_007019049.1\|1012402_1013188_-\|crotonase/enoyl-CoA-hydratase-family-protein	gnl\|CDD\|180625	PRK06563, PRK06563, crotonase/enoyl-CoA hydratase family protein.	4.83996e-121
NZ_CP051183.1\|WP_007019058.1\|1024488_1025106_-\|trimeric-intracellular-cation-channel-family-protein	gnl\|CDD\|225415	COG2860, COG2860, Predicted membrane protein [Function unknown].	3.16256e-52
NZ_CP051183.1\|WP_007019057.1\|1023138_1024395_-\|diaminobutyrate--2-oxoglutarate-transaminase	gnl\|CDD\|236437	PRK09264, PRK09264, diaminobutyrate--2-oxoglutarate transaminase.	0
NZ_CP051183.1\|WP_007019050.1\|1013206_1014997_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173842	cd01153, ACAD_fadE5, Putative acyl-CoA dehydrogenases similar to fadE5. Putative acyl-CoA dehydrogenase (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	1.07501e-157
NZ_CP051183.1\|WP_007019042.1\|1007799_1008252_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	5.97698e-05
NZ_CP051183.1\|WP_007019052.1\|1016405_1017239_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|225543	COG2996, COG2996, Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only].	4.40785e-90
NZ_CP051183.1\|WP_007019051.1\|1015307_1016330_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|227311	COG4977, COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription].	1.23226e-75
NZ_CP051183.1\|WP_007019045.1\|1009838_1010723_-\|folate-binding-protein-YgfZ	gnl\|CDD\|223431	COG0354, COG0354, Predicted aminomethyltransferase related to GcvT [General function prediction only].	1.37743e-55
NZ_CP051183.1\|WP_040298256.1\|1011573_1012239_+\|thiopurine-S-methyltransferase	gnl\|CDD\|213871	TIGR03840, TMPT_Se_Te, thiopurine S-methyltransferase, Se/Te detoxification family. Members of this family are thiopurine S-methyltransferase from a branch in which at least some member proteins can perform selenium methylation as a means to detoxify selenium, or perform a related detoxification of tellurium. Note that the EC number definition does not specify a particular thiopurine, but rather represents a class of activity.	1.09295e-112
NZ_CP051183.1\|WP_007019056.1\|1019773_1022884_+\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|226220	COG3696, COG3696, Putative silver efflux pump [Inorganic ion transport and metabolism].	0
NZ_CP051183.1\|WP_007019055.1\|1018254_1019781_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|379862	pfam16576, HlyD_D23, Barrel-sandwich domain of CusB or HlyD membrane-fusion. HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.	5.64388e-93
NZ_CP051183.1\|WP_007019044.1\|1008978_1009806_-\|HDOD-domain-containing-protein	gnl\|CDD\|224554	COG1639, COG1639, Predicted signal transduction protein [Signal transduction mechanisms].	8.91326e-52
NZ_CP051183.1\|WP_040298255.1\|1010861_1011125_+\|succinate-dehydrogenase-assembly-factor-2	gnl\|CDD\|225489	COG2938, COG2938, Uncharacterized conserved protein [Function unknown].	1.1891e-23
NZ_CP051183.1\|WP_007019060.1\|1025902_1026349_-\|DUF1851-domain-containing-protein	gnl\|CDD\|370180	pfam08906, DUF1851, Domain of unknown function (DUF1851). This domain is found at the C-terminus of a variety of proteins that are functionally uncharacterized.	9.31146e-10
NZ_CP051183.1\|WP_007019053.1\|1017269_1017683_+\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|181730	PRK09256, PRK09256, aminoacyl-tRNA hydrolase.	2.96381e-67

>NZ_CP051183.1|WP_007019050.1|1013206_1014997_-|acyl-CoA-dehydrogenase
MSKLINNKDLSFLLYDVFNANNLSDIPAYADHDQTTYDSVIKTAQRIAEDYFANHNSKADEHEPQFDGEKVSTIPEVKEAWKHFSESGLLNARHSYDDGGMQLPALINSACCGLFTSANPGTAGYPFLTSAAANVIQAFGSDEQKAKYLPGMFNGRFSGTMALTEPDVGSSLGDLTTKAIPQEDGSYKLKGQKMYISGGDQDITENIVHLVLARVEGANKGVKGISLFITPKFLVNDDGSLAERNDVKLAGLLHKMGYRGTTSTVLSFGEEDNCTGYLIGEEGKGLGYMFKMMNEARIGVGLGAAMIGYRGYLESLDYAKNRPQGRKPSSKDSSSKPLNIVEHADVKRMLLAQKSYVEGSLALCLFASRLVDEHEAGGHADSGILLDLLTPIVKSFPSSYGLKANDYAIQVLGGAGYIREYPVEQCYRDNRLNPIHEGTYGIQSLDLLGRKLWMKNSQGLQLLMERVQNTLKQAKDLASLAPQIKRYQQKLNVFSQVVMQLGQSLQSGKVDETLANSALFLDMMGKMVVAWLWIEMASVAQQKLGDSSNQEDQDFVAGKVQACRYFIEWELGEIEHQAELLKSLDSTCADMQENWF
>NZ_CP051183.1|WP_007019049.1|1012402_1013188_-|crotonase/enoyl-CoA-hydratase-family-protein
MSDKKVLVEAKDHILTITFNRPEKYNALDPESYHILAQALYRLQHEKNLRVGIIQSHGDHFTSGLELDKWAPIFANGGEVELAADELDPYGIQGERLTKPLICAVQGLCYTSGLELLLNTDIRIATKETRFAQLEVKRGIYPCGGGTIRLPQEIGWANAQRYILTGDEFNAEQAFNWGLVQEIVARDELHNRARELATKIAKAAPLGVQAALKSSKLSRYRDHETALSTVFEDMPKIIKSKDAQEGVRSFLERREAKFVGE
>NZ_CP051183.1|WP_040298256.1|1011573_1012239_+|thiopurine-S-methyltransferase
MSQHEQEWWHERWQQNQIGFHLPDVHPWLKKYGAEVGIHQAERVFVPLCGKTHDIGFFLSLGMEVVANELNEMAIQSLFEQLDLDPVKSPWKAGTIYQAGSLTVYVGDFFELTHGDVGSVDWVYDRAAVIALPETMRSAYAKQLMAITDKAAQCLITLDYDQNEMDGPPFSVMAEEINNHYADDFKVAVIHERDILEDEPNFKQRGLSRLNQALYLLSCEL
>NZ_CP051183.1|WP_133308531.1|1011355_1011568_+|hypothetical-protein
MSHYDQQAKPISDVSVYSLWSSFLILRYIDHMGNKAWMWVHQNETSMEGFRKLKVLATIGRLEQKDKRVL
>NZ_CP051183.1|WP_040298255.1|1010861_1011125_+|succinate-dehydrogenase-assembly-factor-2
MTEQDLATEKKRLWWHSRRGMLELDVLLLPFLEEVYDDLSEEDKARYRNLLDVEDPELFKWFMQKEKPSDPDHRAIVEIILARVQPE
>NZ_CP051183.1|WP_007019045.1|1009838_1010723_-|folate-binding-protein-YgfZ
MQDLQSYSINDCDYLIIQGPDSAKFMQGQFTCDINQATSHQFLRGACCNAKGRMVASFDLSLIDKDQYLLVMAKGLADILQNHLKKYAVFFKAEIVKKQFNAYHFDTITNSDLTEDFSQSRTGERLIKRQGFNAGFDVIQLSADASGIDATVNVKQPSQDVNLARIQAGLARVTPETSEELIPQMLNLQLTNGVSFKKGCYTGQEIVARMQYLGKLKRHCYRVAFNQAAEVGDSLFAGDKSIGTLVNLAANGDGFEGLAVIEDKHLNAPLTLGSQSTPIEVLCLPYEPQQGDEE
>NZ_CP051183.1|WP_007019044.1|1008978_1009806_-|HDOD-domain-containing-protein
MASLLESVANDLIQQIRDDTLVLPSLPEVCLRVRDVAEDINATIPQLAQIISQDAALSARIVKVANSPLVRTPSEVTDIGTAISRLGINFTSNLAMGLAMEQMFQATSDAVDKRMRSIWHKSSEVASISHVLATHYTKLHPDQAMLAGLIHKIGALPVLTYAEENNALLNDAFALDKLIEKLHPVIGSHILKAWRFPKAILNVPSQYLKFDRDAEKVDYADIVMVAVLQSVANTDHPYTKLDWSTIGAFDRIGINPEVDMAEAIDLDDDLTGLLD
>NZ_CP051183.1|WP_007019043.1|1008290_1008890_-|hypothetical-protein
MAEKRDERLINKDPRAVDEDENQETGLPFFKQPAFIFVLKISLSLGVISSLLTGLFITNSRLTDVEDQILQYQEEISVFKEQQDILKQNLQTLTADHEYLVSEVNALDLSAAQGDLSKALAIYDQQADALNKQLAVTRNGLMSLSRMIKGSRVWQEDYNNQYKKLFEDNKQIQQAIDELRGVQKDKAQREEPQYLEIDF
>NZ_CP051183.1|WP_007019042.1|1007799_1008252_-|GNAT-family-N-acetyltransferase
MQYQQWSAPHFRPINHFYRSQKHKGSASADEIVFVALSSDYNQSHIEAAKEDIQAAVRLVPNDQYFWLRSLYVREELRAQGIGSALMKTVHSHIDATIYCFPYKHLEVFYKTLGYELVEIDQLPNSLLQLYQRYQRKSDDILAMKRSASC
>NZ_CP051183.1|WP_007019041.1|1007207_1007699_-|DUF4442-domain-containing-protein
MSKSNQLSRAVASIQKLPASMHQFAMSKAFGSKIKYAGHSGVRFESLSNQECVVSIKNKKKVQNHIGGVHAAAMALLAETATGFVFGMNVPDDKLPLIKKMDIDYVKRSTGDMRAVATLTEEDIARIQSDERGEVTVPVIITDEANVEPIKASMTWAWTAKKR
>NZ_CP051183.1|WP_007019051.1|1015307_1016330_+|helix-turn-helix-domain-containing-protein
MTEKETRDIWVVGFDGALATAITGVVDLLALAGVTYQRIQGQAIEPLFNLRVVAAERGPIRCINGLNLYAEHDFQSLMSNVDSEGVVAPYAVVVPTIGADIGQTLNNNHPMLAFLKWAKQNCQIISANCTGNFFLAEAGLLNGKQATTHWGFEDVFKRHYPNVDLRIDQLITQDDNIYCAGGGLAWFDMGLLMIEQHAGYEVAIQTARAFVIDYRRQSQLSYRLHRMRPNHQDSLIQSIQDYLDAAYHKPVTLDDLAKTFNISQRTLIRRFKQALDMTPHSYIQNLRMEVAQKALAETERTVETVMQQVGYEDVSAFRRLFKQHTGLTPNAYRDRFARRL
>NZ_CP051183.1|WP_007019052.1|1016405_1017239_+|GntR-family-transcriptional-regulator
MIQIGRYNDLPVVRQLPRGLQLDGGRAGEILLPKQYLTGDEQVGDVMTVFIYRDSEDRLIATTEQPKVQVGEFAYLNVVDETKHGCFLDWGLPKDLFVPFSEQRQALKKGKQALVRVYLDDSNRIAASAKIDSFLLDIDDANVYKKGDEVTIVSAAKSDLGLKVIVNGTHWGLIYESDLFEPLKRGDKRKAYIKRVRDDHKLEISLRPLGFAKVEGLAGEVLDKLKAEGGFIALSDKSSPEAIKRVFKCSKNAFKQAIGTLYKQQLIKIEKEGIRLL
>NZ_CP051183.1|WP_007019053.1|1017269_1017683_+|aminoacyl-tRNA-hydrolase
MLFISHRVQIPNDEIEMHAMRAQGSGGQNVNKNSTAIHLRFDIKASSLPDLYKDKLLAMSDHRITKDGEIVIKSQEHKSQELNKEAALARLAAMIKEANKEQKKRKPTKPSRSSQRKRMDKKTKHGQKKAMRKSVAL
>NZ_CP051183.1|WP_007019054.1|1017755_1018196_+|hypothetical-protein
MMHALRQTLQSILGTAIYVVLLCVLVLQSWLVGACPMVSGTAQLSSTSVVSETDHMMMDHRHHQDMSNVSMADHSMHNSHSIDLQQSECADKDASCPMLALLHGHHDSIVWMTPSISARTIQIELPTIATQQHPSSLYRPPIRSLI
>NZ_CP051183.1|WP_007019055.1|1018254_1019781_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MVKKFLAALILLLVGALLGWQVAPLFSSAESEASSSNEPLYWVAPMDPNYRRDSPGKSPMGMDLVPVYEESSAEDSPGLVRINPDVENNLGVRTALVEEGPLSMTLTASGIVQFNEEAIQHIHPRVEGWVEKLHVKAVGNPVEKNQPLYDLYSPQLVNAQEEFLLALKSNNASLLEASLDNLRALNFPQATIQALRKDKTVKQTVTFRAPQSGVLENLQIREGYFVGPSKTLMSIVNLDKVWVEAEVFQSQLHWLKQGLAVSVALHGFDDKLNGQVDYIYPQLNMQNRTGRVRIVLNNPQQKIKAGMYADVTFATQSSKAVTYVPREAVIRLGDSNRVVKHVADGQYKSIAVKTGVSNEQFIAIEQGLKLGERIVTSAQFLIDSESSKQSDFKRIDRGSATRLPNASVMGKVNYVDAKNSVINISRAAIEKWNRPAATMDFVLDPSIPNKLINGLHKSQSIHFMFVIDDDEFYVTEIHPMESEPADHDNMNHSEMGHGSMNHEDMNHD
>NZ_CP051183.1|WP_007019056.1|1019773_1022884_+|efflux-RND-transporter-permease-subunit
MIKQLIHWSVHNRFLVVLATVLVIAFGIFSVKNTPVDAIPDLSDVQVIIKTQYPGQSPQVVQDQVTYPLTTALLSVPGAKTVRGFSFFGDSYVYVIFDDDTDIYWARSRVLEYLNQVDLPNGVKSQLGPDASGVGWVFLYALQDKTGQLDLSQLTSLQNWFLKYELQTVPGVSEVATVGGMVKQYQVTVDPVKLRGYNIPLAHISNAIQQGNQETGASVIEMAEAEYMVSSSGYIQNQQDLREVPLGLNENGSPLLLGDVADVRLGPQMRRGIAELDGEGETVGGIIVMRSGENALQTIDGVKKKLESVKLGLPEGVEIIPVYDRSGLIYRAVDNLWNTLIEELAIVVLVCIVFLFHVRSSLVAMISLPVGILVAYIIMYLQGINANIMSLGGIAIAIGAMIDGAIVMIENMHKHMERTPLNRENRWQVVVQAAQEVGPALFFSLLIITVSFIPVFTLEAQEGRLFSPLAFTKTYAMAAAAALSITLVPVLMGYFVRGRVLPEKKNPVNRLLIAGYAPVLKRLLHYPKTVLSVALIFVLVTLWPMQKLGSEFMPPLDEGDLMYMPTTYPGLSIGKARELLQQTDKLIKTVPEVDRVFGKVGRAETATDPAPLTMIETFIQLKPREQWRDGLTTKGLIDELESLVKFPGLSNAWVMPIKTRIDMLATGIKTPVGIKVAGDDLSVIEDIGKQIEQSLAELENTASVYSERVSAGRYIKVDIRRQQAARYGLNIADVQQVIASAIGGRNITQTVEGLERYPINVRYPQTYRDSPEALEALPIIAANGMELSLGQVADIYVELGPGAIKSENARINGWSFIDIKDIDVGSYMKMAQQKIEEDIQIPAGYSLKWAGQFEYMERAKQKLMLVVPLTLIIIIVLLYLSFRRLGEVAILMTTLPFSLTGSIWLMYALDFNFSIAVGVGFIALAGVAVETGVIMLVYLNQAYDEYMKQNASQKTTLLQTVYEGASLRVRPVLMTAGATIAGLLPILFSTGTGSEIMSRLAAPMVGGMLTSIILTLFIIPVIYYSWKSLCRQKMKD
>NZ_CP051183.1|WP_007019057.1|1023138_1024395_-|diaminobutyrate--2-oxoglutarate-transaminase
MDIFNDYESEVRGYIRSFPTVFDKAIGAELFDEDGTRYIDFFAGAGTLNYGHNPEVAVEAQIKYLQDRRIAHGLDKATVAKQEFMESFVEKILKPRNLEYKLQFTGPTGTNCTEAAMKLARQAKGRPGIVAFTNAYHGHTMGALAATGNESYRDDTYGARGATSFMPFDGFLGQDIDSLHVFRRYLEDKGSGLELPAAVIIETVQGEGGINVASQEFLQGLAALCKEYDMVLIIDDIQVGNGRTGKFFSFEEAGIKPDMVCLSKSIGGGNPMAVLLINPEIDVWSPGEHTGTFRGNSLAFVAAKQLIDQYWSDDKLTQEVDRKSKVMRAALEELRDEFPSLNCDVRGRGLVLGIETKVEGFADEVSAKAFEKKLICETCGAESTVNKLFVALNIDDAIFNEGLEVFKEAFREVAKKHA
>NZ_CP051183.1|WP_007019058.1|1024488_1025106_-|trimeric-intracellular-cation-channel-family-protein
MILDIIYFAGLGGTLVFAISGALAAAENELDILGFILFATVTGIGGGTVRDLILGVEVAWAHGQHAYDLHICVAAAVVTYFLAPQFIKRMRLLVWMDAMGLAIFSAVGTAKAYELGLSPLVCVAMGMITPTFGSMIRDILSDRQPELLQPEIYVTASIVGGVSFLLSMQVLTNPQLSILLAALSAFLVRSASIVYNLRLPKFTNK
>NZ_CP051183.1|WP_007019059.1|1025110_1025899_-|META-domain-containing-protein
MRFSIILTASLLLSACSNLQHEHKANSQHTSRNSLDWATSYYGQLPCADCPGIETQIRLFDFDEEANHGHYQRLSNYLGQPNSRFFKESGTFRWTADGNSIELIKEGQVSNTWRVFEDSLLMLEQNENPIETSMSKAYRLNKLSTKQRLAGEMQPRTWVFSEILGHTLDSSSEAFLAFNVDEMRAAGFTSCNRLTGPIEVSDQQLRFGRLAMTRRACPESSIESQVLQVLHRTAHYQFQQYALVLLDSDKQTLAKLGLSVKE
>NZ_CP051183.1|WP_007019060.1|1025902_1026349_-|DUF1851-domain-containing-protein
MSDVLALIKQYWGFTGINPEKVIAENEFGNFILHDVDGRFWRLCPEDLYCEIIADNKDEYNELVQEVEFNQDWFMEVILEKAVEKYGELKPGYKFHLLEPGALGGKYAVFNIQPMPVEKIIKFSGELEHKRQRAGGKKVSYTPLSQES

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Crispr_ID: NZ_CP051183_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP051183_5

1416584-1416685

Orphan

Consensus_repeat	Method
ATTCCCGACTTGATCGGGAATCCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP051183_5

>merge|NZ_CP051183|5|1416584-1416685|CRISPRCasFinder
ATTCCCGACTTGATCGGGAATCCAGGTAAATATGAACGTCATCCTCAGCTTGACTGAGGATCCAAAAAAGAAAGCGTGATTCCCGACTCGATCGGGAATCCA

>NZ_CP051183|5|5|1416584-1416685|CRISPRCasFinder
ATTCCCGACTTGATCGGGAATCCA	GGTAAATATGAACGTCATCCTCAGCTTGACTGAGGATCCAAAAAAGAAAGCGTG
ATTCCCGACTCGATCGGGAATCCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP051183.1\|WP_007017517.1\|1416737_1417775_+\|UDP-glucose-4-epimerase-GalE	unknown	unknown	gnl\|CDD\|187558
NZ_CP051183.1\|WP_007017514.1\|1412044_1413697_+\|glucose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234679
NZ_CP051183.1\|WP_007017520.1\|1419940_1421029_+\|DegT/DnrJ/EryC1/StrS-family-aminotransferase	unknown	unknown	gnl\|CDD\|99740
NZ_CP051183.1\|WP_007017525.1\|1425507_1426548_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133039
NZ_CP051183.1\|WP_007017508.1\|1405913_1407596_+\|30S-ribosomal-protein-S1	unknown	unknown	gnl\|CDD\|235775
NZ_CP051183.1\|WP_083771902.1\|1422736_1423999_+\|polysaccharide-pyruvyl-transferase-family-protein	unknown	unknown	gnl\|CDD\|377253
NZ_CP051183.1\|WP_007017519.1\|1419062_1419944_+\|glucose-1-phosphate-thymidylyltransferase-RfbA	unknown	unknown	gnl\|CDD\|130274
NZ_CP051183.1\|WP_040297702.1\|1423988_1425506_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240533
NZ_CP051183.1\|WP_007017513.1\|1411666_1411972_+\|integration-host-factor-subunit-beta	unknown	unknown	gnl\|CDD\|178925
NZ_CP051183.1\|WP_007017516.1\|1415663_1416557_+\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	unknown	unknown	gnl\|CDD\|184021
NZ_CP051183.1\|WP_007017526.1\|1426686_1427796_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NZ_CP051183.1\|WP_007017521.1\|1421025_1422231_+\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|237195
NZ_CP051183.1\|WP_007017518.1\|1417975_1419061_+\|dTDP-glucose-4,6-dehydratase	unknown	unknown	gnl\|CDD\|236649
NZ_CP051183.1\|WP_007017510.1\|1408874_1409975_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340839
NZ_CP051183.1\|WP_133308464.1\|1410013_1411084_+\|CDP-glycerol--poly(glycerophosphate)-glycerophosphotransferase	unknown	unknown	gnl\|CDD\|224799
NZ_CP051183.1\|WP_007017515.1\|1413856_1415296_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|224157
NZ_CP051183.1\|WP_007017512.1\|1411080_1411476_+\|adenylyltransferase/cytidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|173922
NZ_CP051183.1\|WP_007017507.1\|1405076_1405757_+\|(d)CMP-kinase	unknown	unknown	gnl\|CDD\|234579
NZ_CP051183.1\|WP_007017522.1\|1422227_1422641_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP051183.1\|WP_168367052.1\|1407723_1408869_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319746

Protein	Function_ID	Function_description	E-value
NZ_CP051183.1\|WP_007017517.1\|1416737_1417775_+\|UDP-glucose-4-epimerase-GalE	gnl\|CDD\|187558	cd05247, UDP_G4E_1_SDR_e, UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	0
NZ_CP051183.1\|WP_007017514.1\|1412044_1413697_+\|glucose-6-phosphate-isomerase	gnl\|CDD\|234679	PRK00179, pgi, glucose-6-phosphate isomerase; Reviewed.	0
NZ_CP051183.1\|WP_007017520.1\|1419940_1421029_+\|DegT/DnrJ/EryC1/StrS-family-aminotransferase	gnl\|CDD\|99740	cd00616, AHBA_syn, 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.	5.35534e-118
NZ_CP051183.1\|WP_007017525.1\|1425507_1426548_+\|glycosyltransferase	gnl\|CDD\|133039	cd04196, GT_2_like_d, Subfamily of Glycosyltransferase Family GT2 of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	2.24248e-19
NZ_CP051183.1\|WP_007017508.1\|1405913_1407596_+\|30S-ribosomal-protein-S1	gnl\|CDD\|235775	PRK06299, rpsA, 30S ribosomal protein S1; Reviewed.	0
NZ_CP051183.1\|WP_083771902.1\|1422736_1423999_+\|polysaccharide-pyruvyl-transferase-family-protein	gnl\|CDD\|377253	pfam04230, PS_pyruv_trans, Polysaccharide pyruvyl transferase. Pyruvyl-transferases involved in peptidoglycan-associated polymer biosynthesis. CsaB in Bacillus anthracis is necessary for the non-covalent anchoring of proteins containing an SLH (S-layer homology) domain to peptidoglycan-associated pyruvylated polysaccharides. WcaK and AmsJ are involved in the biosynthesis of colanic acid in Escherichia coli and of amylovoran in Erwinia amylovora.	7.39975e-24
NZ_CP051183.1\|WP_007017519.1\|1419062_1419944_+\|glucose-1-phosphate-thymidylyltransferase-RfbA	gnl\|CDD\|130274	TIGR01207, Glucose-1-phosphate_thymidylyltransferase_1, glucose-1-phosphate thymidylyltransferase, short form. Alternate name: dTDP-D-glucose synthase homotetramer This model describes a tightly conserved but broadly distributed subfamily (here designated as short form) of known and putative bacterial glucose-1-phosphate thymidylyltransferases. It is well characterized in several species as the first of four enzymes involved in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	0
NZ_CP051183.1\|WP_040297702.1\|1423988_1425506_+\|hypothetical-protein	gnl\|CDD\|240533	cd13128, MATE_Wzx_like, Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	7.69716e-25
NZ_CP051183.1\|WP_007017513.1\|1411666_1411972_+\|integration-host-factor-subunit-beta	gnl\|CDD\|178925	PRK00199, ihfB, integration host factor subunit beta; Reviewed.	4.00091e-59
NZ_CP051183.1\|WP_007017516.1\|1415663_1416557_+\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	gnl\|CDD\|184021	PRK13389, PRK13389, UTP--glucose-1-phosphate uridylyltransferase GalU.	4.83946e-171
NZ_CP051183.1\|WP_007017526.1\|1426686_1427796_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	2.53668e-36
NZ_CP051183.1\|WP_007017521.1\|1421025_1422231_+\|ATP-grasp-domain-containing-protein	gnl\|CDD\|237195	PRK12767, PRK12767, carbamoyl phosphate synthase-like protein; Provisional.	5.08044e-18
NZ_CP051183.1\|WP_007017518.1\|1417975_1419061_+\|dTDP-glucose-4,6-dehydratase	gnl\|CDD\|236649	PRK10084, PRK10084, dTDP-glucose 4,6 dehydratase; Provisional.	0
NZ_CP051183.1\|WP_007017510.1\|1408874_1409975_+\|glycosyltransferase	gnl\|CDD\|340839	cd03811, GT4_GT28_WabH-like, family 4 and family 28 glycosyltransferases similar to Klebsiella WabH. This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.	1.15221e-72
NZ_CP051183.1\|WP_133308464.1\|1410013_1411084_+\|CDP-glycerol--poly(glycerophosphate)-glycerophosphotransferase	gnl\|CDD\|224799	COG1887, TagB, Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane].	5.22765e-12
NZ_CP051183.1\|WP_007017515.1\|1413856_1415296_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|224157	COG1236, YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis].	7.00839e-90
NZ_CP051183.1\|WP_007017512.1\|1411080_1411476_+\|adenylyltransferase/cytidyltransferase-family-protein	gnl\|CDD\|173922	cd02171, G3P_Cytidylyltransferase, glycerol-3-phosphate cytidylyltransferase. Glycerol-3-phosphate cytidylyltransferase,(CDP-glycerol pyrophosphorylase). Glycerol-3-phosphate cytidyltransferase acts in pathways of teichoic acid biosynthesis. Teichoic acids are substituted polymers, linked by phosphodiester bonds, of glycerol, ribitol, etc. An example is poly(glycerol phosphate), the major teichoic acid of the Bacillus subtilis cell wall. Most, but not all, species encoding proteins in this family are Gram-positive bacteria. A closely related protein assigned a different function experimentally is a human ethanolamine-phosphate cytidylyltransferase.	2.0023e-50
NZ_CP051183.1\|WP_007017507.1\|1405076_1405757_+\|(d)CMP-kinase	gnl\|CDD\|234579	PRK00023, cmk, (d)CMP kinase.	2.05307e-122
NZ_CP051183.1\|WP_007017522.1\|1422227_1422641_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.05824e-21
NZ_CP051183.1\|WP_168367052.1\|1407723_1408869_+\|hypothetical-protein	gnl\|CDD\|319746	cd16438, beta_Kdo_transferase_KpsS_like, beta-3-deoxy-D-manno-oct-2-ulosonic acid (Kdo)-transferase KpsS like. KpsS is a beta-3-deoxy-D-manno-oct-2-ulosonic acid (Kdo)-transferase. It is part of the ATP-binding cassette transporter dependent capsular polysaccharides (CPSs) synthesis pathway, one of two CPS synthesis pathways present in Escherichia coli. The poly-Kdo linker is thought to be the common feature of CPSs synthesized via this pathway. CPSs are high-molecular-mass cell-surface polysaccharides that are important virulence factors for many pathogenic bacteria.	6.18209e-120

>NZ_CP051183.1|WP_007017516.1|1415663_1416557_+|UTP--glucose-1-phosphate-uridylyltransferase-GalU
MVKKAVIPVAGLGTRMLPATKAIPKEMLPIVDKPLIQYIVEECAAAGITEIVLVTHSSKNAIENHFDTSFELESTLEKRVKRQLLEEVQSITPDGVTIMHVRQGHAKGLGHAVLCALPVVGEEPFAVVLPDVLIDQYESDLKTQNLAQMIKTFDATNVSQIMVEAVPQEKVSNYGVVDLNGESLEAGNSQAMTAIVEKPKVDEAPSNLAVVGRYVLSEKIWDLLKYTPPGAGDEIQLTDAIADLMKQERVDAFYMNGKSHDCGSKLGYMKCFVEYGLKHQADGEAFGEWLGHRHSPA
>NZ_CP051183.1|WP_007017515.1|1413856_1415296_+|MBL-fold-metallo-hydrolase
MINHHGAVSGVTGSCHELRYTHRGQEKGVLIDCGLFQGDEALNAELQNGGRPDKTQEQLLSENIPFPIDHIAALVVTHVHIDHVGRIPYLIAKGFDAPIYCTVASAHLLPLVLEDALKVGFTRNQALIDMFLSKIKQQIRPLAYNQIQHIDESLSIKLSPAGHILGSAYVTCELKSSSPPRRGTNPKETKTIIFSGDLGASQSPIIRSFQSPEACDELVLESTYGDKNHEDRVTRQQRLQKILERALEDGGTVLIPAFSIGRTQELLYEIEDILHNNERNSKHSKLNVMVDSPLAAQFTQSYRELKHLWDDEAQAKLKQGRHPLNFDELTTIESHKEHLETIDYLVRSRKPAIVIAASGMCNGGRIMNYLKAMLGENRNDLLFVGYQASGTIGRLIQKYGPKGGYVDIDGKRIIIKANIHTISGYSAHADQSDLKFFVRGMKQKPKKIRLIHGDGSAKRELRAQLNHDFPDIDVIIPEK
>NZ_CP051183.1|WP_007017514.1|1412044_1413697_+|glucose-6-phosphate-isomerase
MLTSLPEYQALSQHYSDVQQTSMRQWFEQNPNRFTEYTLQAAGITLDYSKNRVACETMQKLADLARARFIPEAIEAMFKGDLVNPSEGRPALHTALRNFSDGPVMVDGKDVMPEVRKTLTRMKEFCWRIRNQHWRGFSNKPFTDVVSIGIGGSFLGPKLASQALKPYWGKKINCHYLANIDGSNLTEVLQGLNPETTLFIVQSKSFGTQETLKNAIECRQWFLDNGGQESDLPRHFTAVTANVEKAKAFGINEKNIFPMWDWVGGRYSLWSAIGLPLMLTIGHENFKQVLQGAHEMDVHFRTAPLEQNMPVIMAMLGVWYINFFNAQSHAILPYDHYLRGLPAHIQQLDMESNGKSVDIHGSKLNYQAGPIIWGGVGSNGQHAYHQLLHQGTQFVPCDFIMPLQTHNPVDSFHELLISNCLSQSQALMQGKTLEEAKEELRKEGKSEREIAVLAPQKVIPGNRPSNTIFFDKANPKIVGALIALYEHKVFVQGKIWDINSFDQWGVELGKQLGNQVHAAIQAEGDTNIDNHFDASTLGLIKAFRSMKHKL
>NZ_CP051183.1|WP_007017513.1|1411666_1411972_+|integration-host-factor-subunit-beta
MTKSELIERITEKHPEMSAKDIELAVKTILDTMSQALSQGERIEIRGFGSFSLHFRNPRVGRNPKTGEAVPLKGKYVPHFKPGKELREQVNDLVNGDSMMV
>NZ_CP051183.1|WP_007017512.1|1411080_1411476_+|adenylyltransferase/cytidyltransferase-family-protein
MSKRVITFGTFDVFHVGHINILERAKSQGDYLIVGVSSDKLNFEKKGRYPVYSQSQRMKILSALSCVDEVFVEESLEKKPDYIQEYNANVLVMGDDWSGKFDTMKAFCDVVYLPRTPSISTTEIIEVVKNL
>NZ_CP051183.1|WP_133308464.1|1410013_1411084_+|CDP-glycerol--poly(glycerophosphate)-glycerophosphotransferase
MYFDVEELYYLPQYLPIRRILRLYGATTVFVLQGQQSNRVPRILLDEGVGIEEVRFVSSKSEALNLCIVDKPDWLILGNSFSGIDDLHPNTKTALVSHGIGPKSCYYTVSDTPTTVRFVEGPYRTARLQEMYPGQCFVDTGYAKLDPAVNGDLGGTKPSDYGLDDNKKTLLYAPTFYPSSIECFDHQFPLHFSEYNIILKPHFFSLSVSKYEKQKNILERWAKYPNVYLADVDESNILPFMVVADVLISDASSTLFEFAALNKPVVWCDFLKLRWTYRGIFSFRFRKRMDPDLYKYADIAAHAKSYRELKSVIQKQITHPDEFASQRSRYTLSLAGNVDGKASERIVQYILNYEEA
>NZ_CP051183.1|WP_007017510.1|1408874_1409975_+|glycosyltransferase
MKTKKNIVIIIDSIGGGGAERVMLDLARGIVQSGHNAFFIALEKRIDHQVYEEVPVFILYDDRDLKAITRRKKARLQSAKKLEGLVSEIETSHGKIHLFLSNLDPTNGVVALTKFDNVKYVLHSAMEKEVKRERRLGPFKYFRKIMQKRVMNDKDLVAVSQGVATEAATLGLIKPRSVTTIYNPCNVALIRTMSEQYAPEIPNKPFILHVGRVVKAKRHDILFSALALVPDQIMVCLCKDVEKAKAIADKYGVADRVVLPGFTNNPYAWMKRAELTVLSSDYEGLPTVLIESLICGTPIVSTNCTYGPSEIMTDKLSEYLCDTGDPFALSKNIKKALVDYPDLESLPILKAVELSNVVDQYLKLAN
>NZ_CP051183.1|WP_168367052.1|1407723_1408869_+|hypothetical-protein
MDVLFISSKGSQYRYYKTLAKNTLFKARVVTLFPGFGFKIFNTGLNKKVINEGLDFHLERKKRKYSNQFPNAFVMKVYTAFSALYFSLIYLKFRRYLTSHRPKNICIWNGHRLPEMAVKAAARGLDIKIFYFENGLIPNTTVMDSSGVNAFSSLPKDPNFYLEYAKQSTDKVDCLENKSLVARKPHKSRKKLRFSEADLNKRYVFVPFQVNFDSQVIVNSPVVNSMHKLYEFVELLLQETPSDLLFYIKEHPSDSHTYSELHKKHDRIQFVDENTEELIRNADAVLTLNSSVGIEASMLGKPVIVLGNACYAIQKLVYVSTSFRQVAEILNNLEQPDQKVRQAFFSYLENKYLLPGAWQNYQRNIDSKHLECFENKIKGDF
>NZ_CP051183.1|WP_007017508.1|1405913_1407596_+|30S-ribosomal-protein-S1
MSESFAELFEESLSGLDMQQGSIVTGTVVDIDSDWVIVNAGLKSEAVIPRNQFLDDNGELEVAVGDEVPVSLEAVEDGFGETKLSREKAKRAESWKELEKAFEAQEVVTGVINGKVKGGFTVDVASIRAFLPGSLVDVRPVRDTAHLEGKELEFKVIKLDQKRNNVVVSRRAVLETANSQERDELLANLQEGQEVTGIVKNLTDYGAFVDLGGVDGLLHITDMAWKRIKHPSEIVNVGDEIQVKVLKFDRERNRVSLGLKQLGEDPWVAIKARYPENTKVTAKVTNLTDYGCFAELEEGVEGLVHVSEMDWTNKNIHPSKVVQVGDDVEVMVLDIDEERRRISLGIKQCQVNPWEEFSSQFNKGDKISGKIKSITDFGIFIGLDGGIDGLVHLSDISWNEQGEDAVRNYKKGDELETIILSIDPERERISLGVKQLERDPFAEFVAENDKGTIVKGKVIEVDAKAATIEIAEGVEATLRASEISRDRVEDARNALKEGDEVEAKIISVDRKNRNIALSVKSKDEVDDKEAIKQLREKEAEQAGPTTIGDLIKEQLNSQKD
>NZ_CP051183.1|WP_007017507.1|1405076_1405757_+|(d)CMP-kinase
MSQVPVLTIDGPGGAGKGTICQMVAKKLKWHLLDSGALYRLTALAAQKHDVELDNEESVAVLAKCLDVQFLPQEEGLVNTILEGEDVSQAIRTEEAGNLASQVAAMPAVRQALLERQRDFAQAPGVVADGRDMGTVVFPDAPVKIYLTASAEERAKRRFLQLQEKGVDADIEKILMDIQARDERDMNREVAPLRPAEDALVVESTNMSIEQVLDVVITELESKNLI
>NZ_CP051183.1|WP_007017517.1|1416737_1417775_+|UDP-glucose-4-epimerase-GalE
MPKTILVTGGAGYIGSHTCVELLEAGYDVVVLDNLSNSNPKSLDRVQEITDKTLQFIEGDVRDREVLQAIFNKHDVYGVIHFAGLKAVGESCEMPMHYYDNNVYGSIVLTQEMEKAGVKNLVFSSSATVYGDPERLPLTEDMPLSATNPYGRSKLMIEDMLRDLEVADQLTEQEIKWNIAILRYFNPVGAHKSGNIGEDPNGIPNNLMPYITQVAIGKLKELQVFGGDYDTHDGTGVRDYIHVVDLAKGHVKAIEAIGHTVTGAKAINLGTGNGLSVLDLVKSFEKQNSVSIPHKITDRRPGDVAACYADSSLAQQLLDWRTEYNEEQMTKDSWHWQQKNPTGYK
>NZ_CP051183.1|WP_007017518.1|1417975_1419061_+|dTDP-glucose-4,6-dehydratase
MSKKILVTGGAGFIGSAVVRHILNDTHDSVVNLDKLTYAGNLESLNEIAGSERYAFEQVDICDRPALERVFAEHKPDAIMHLAAESHVDRSIDGPAAFIETNIVGTYTLLEVARAYWNGLPEKQKNSFRFHHISTDEVYGDLENPEDLFTEETAYAPSSPYSASKASSDHLVRAWKRTYGFPTIITNCSNNYGPYHFPEKLIPLVILNALEGKELPIYGKGDQVRDWLYVEDHARALYKVVTEGQIGETYNIGGHNEKQNIEVVQTICELLEELVPENAYSRMGGNPSGFKGLIAYVEDRPGHDLRYAIDASKIQKELGWTPLETFESGIRKTVEWYLSNKEWVQHVQDGSYQRERLGVSV
>NZ_CP051183.1|WP_007017519.1|1419062_1419944_+|glucose-1-phosphate-thymidylyltransferase-RfbA
MKGIVLAGGSGTRLYPITMGVSKQLLPIYDKPMIFYPISVLMLAGIRDILIISTPEDMTGYQRLLKDGSQFGVKFSYEIQPSPDGLAQAFIIGEEFIGDDDVALVLGDNIFYGQGFTPKLKEALENAKGGKGATVFGYQVKDPERFGVVEFNQSMKAISIEEKPKNPKSNYAVTGLYFYDNRVVDIAKTVKPSDRGELEITCINNAYLEQNSLNVELLGRGFAWLDTGTHESLLQAAQFVETIESRQGYKVACLEEIAFNNGWLSKSDLKELAKPMQKNSYGKYMLSLAKGEL
>NZ_CP051183.1|WP_007017520.1|1419940_1421029_+|DegT/DnrJ/EryC1/StrS-family-aminotransferase
MIPVTKPYLPSREKLDAYIDGIYERSWLTNNGPLLKELTKKLEEYLGVENILLVSNGTLALQVAYKTLGISNTGCTENAEAITTPFTFVATASSLQWEGVKPVFTDISADSWCLDPANIESAITEKTRAIVPVHVFGNACDVEAIDQIAEKHQLKVVYDASHAFAVNYKGNSLLNWGDAATLSLHATKLFHTIEGGAIVFKHKADLERAQQIINFGLAGPEDISGPGINAKMNEFQAAMGLCVLDEMETITNNRKQIGQSYQRELRGRVVFQKWNKHGESNHAYAPVLFESETELLAVEAKLKENNIFSRRYFYPSLDNLEHFKSEQVCANSRDIASRILCLPLFPNMTDEERSKVIKVLMK
>NZ_CP051183.1|WP_007017521.1|1421025_1422231_+|ATP-grasp-domain-containing-protein
MSQKRILFLGASAQQIPPIKYALDQGHYVITCDYLPGNPGHQLAHEWHNVSTTDKEAVLSLARELKIDGIVAYASDPAAPTQAYVAEKMELVGNPYESVEILARKDYFREFLVKNGFNTPRSESFYELDQAKKWLDTIGTPAFIKPIDSSGSKGVTNIKHRNDLEKAFNYALSFSREKKVVVEEAIARSGYQVDSDIFMSRGEIVFWIWGDQHQDILCHPYAPIAISFPSVLSAEAQVKAKNEVEAILKKLGFMFGAFNVEFVVDEKGDVWVIEIGPRNGGNLIPQVIKYVSNVDMIAATVDESIGKSFDKSVNRELNGYWSSYIVHAREDGIFKELYLSERVKPYIVEQHIYAKAGDEVRQFSGSQDTLGMMILKYPSMETMLDMTDNMENDILVLTEER
>NZ_CP051183.1|WP_007017522.1|1422227_1422641_+|GNAT-family-N-acetyltransferase
MSYSEIESLIKAEQMRQKKSFIDTDDIDKYIFKIKSNAEFITHYTSGQCAGFIAFYCNEPTKKIAFITLVLLAPEFRGKGLASNLINYVIEHCKKNKFEKCSLEVRKDNLSAIKLYEKHGFKIKQDCDAKLLMSISF
>NZ_CP051183.1|WP_083771902.1|1422736_1423999_+|polysaccharide-pyruvyl-transferase-family-protein
MEFGNIGNYYIIEPFMRELHRVFPNASIKTTMQMSERFCEGERVTLLPMNLYYGWTGNDLEIAQEELKLAEAYAESGCLKKETPYIQEVMQADLVIDFSGDIWGDNANFLGDDRFLVGLIKDRVAQLLGKKVVMLAGSPGPFSNKDNLPFAREVFKCFDLITNREPISIDLLKKDGFDTSKTLSLACPAFLFDRAEGADVDKLLSEEGLRNKDKPIVGFILCGWNFEVGPFDKENRDDEDFTKFAETVEYLTEELGVRVCLMSHSNGFDIPPAPFKLKHGRDYVITKQLEKILDERSISKDFFTLNGVYDTWTTKAIINEFDMLVSGRVHAAVSGLSQSVPTVIIDYGHEPKAHKLVGFAKVAQVEEYVADPCSLTDLKTKVFKCYSQREQYKESLNKRIPVVKKLARQNFEVLKSVLDQ
>NZ_CP051183.1|WP_040297702.1|1423988_1425506_+|hypothetical-protein
MINSNSLRKNTLANYIGQAYMMLIGIVVTPLYLQHLGAEAYGLVGFFALMQAWMNLLDMGLGPTLGRQAAYARGQVEGFETFKRLLKSFEVIFFVLAVIIVFAIYILSDWIAISWIKSESIAIETLVYCVVLMGVMIGLRWFSGLYRSGINGLEDQVWLNVANIILTSLKFLGALCLLAFISQDIRHFFEYQVLIGLIELAAFSIRFYSILPVTKTRTPLVAFYWSVVKDVAPFAVGIAYTAGTWVLITQTDKLILSGVLSLAEFGYFSMISLVAGGIVMLSGPISQAIMPRLTMLYSQDNKNELLSLYSDASQLVTVTSLSVSLMIGLYAEPLIYAWAGDREAAEWGAGVLIWFALGNGVLAIAAFQYYLQSAFGQLRLHVIGSTLSAIIQVPLIFYAATNYGAQGAGITWFAFRTIWFLCWTPVVHRQFIPGFHLRWMLKGILPIAIVTMCVALAMHFLITLDLNQNRLDLFAKLISLGLLLLSVSALSSSAIRQRIFRLLKN
>NZ_CP051183.1|WP_007017525.1|1425507_1426548_+|glycosyltransferase
MRDLRTEEEIISNWKNGIDKPVVSVCCLTFNHEPYIEDALEGFLIQETDFPFEILIHDDASEDNTANIVRRYQARYPNIIKPIYQTENKYSKGIKINLVYNFSRAKGEYIALCEGDDFWVASDKLKEQITLMKQYPHINISFHPVYQVEGFEFSKAKTLCDYSDVIRQYSPEEVILGGGIFMPTNSLMVKTAILKNLPEWFSTHAPVGDMYIQMIASLGGGAIYMPQKNGAYRTNIPGSWSSMHIKMECQKIEEYANNHIYCFTAFGAENVKFKNEILRALAFELVSCAWNSMKNNCDELAKSLVEKSTSYSECKYINFNQAVLVIFKRNFKILRFLLKLKNRIIA
>NZ_CP051183.1|WP_007017526.1|1426686_1427796_+|glycosyltransferase-family-4-protein
MKVILFSHEFPPYIGGVGRIGYDLLQLYTRTVGVEASLVTRSKPTPKLINRVKVNRVFTLPKIWFLNYALFYFFNRRLFREADVIYLNEAAPTIAAGMFFSKSDLSKCVIIAHGLEVEGVINSKQLVHRVLGLSRFYKRAVRISKKVVALSEAMRAKMCRALPSDYRRFIDVAYLGIDPEIFHYKPTLERDQRFQSVVESKVIGTCSRLIWQKGYKEMADTFAMAHKKDSSLLWYIAGDGEDALDIKDYIKFLGLENSVTFLGAFDYTELSSFYSFIDIFMLLSNYDEVFPLVYLEAQACGARSIGRNKGGTVEVVDLNTGCLVDDNIDAASFILSCPKNFDRKKVIEFTENFIIRENFKKWRDICEGL

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Crispr_ID: NZ_CP051183_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP051183_6

1434447-1434562

Orphan

Consensus_repeat	Method
ATCTAATTTATTTCGCGTCAATCAATGGATA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP051183_6

>merge|NZ_CP051183|6|1434447-1434562|CRISPRCasFinder
ATCTAATTTATTTCGCGTCAATCAATGGATACCCGATCAAGTCGGGTATGACGGGGCGTGTCATTCTCAGCTTGACTGAGGAGCCATCTAATTTATTTCGAGTCAATCAATGGATA

>NZ_CP051183|6|6|1434447-1434562|CRISPRCasFinder
ATCTAATTTATTTCGCGTCAATCAATGGATA	CCCGATCAAGTCGGGTATGACGGGGCGTGTCATTCTCAGCTTGACTGAGGAGCC
ATCTAATTTATTTCGAGTCAATCAATGGATA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP051183.1\|WP_007017541.1\|1443334_1443910_-\|YecA-family-protein	unknown	unknown	gnl\|CDD\|377099
NZ_CP051183.1\|WP_007017530.1\|1430516_1431311_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133038
NZ_CP051183.1\|WP_007017539.1\|1441334_1441637_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NZ_CP051183.1\|WP_007017531.1\|1431414_1432725_-\|sugar-transferase	unknown	unknown	gnl\|CDD\|274398
NZ_CP051183.1\|WP_133308465.1\|1436196_1437111_-\|ornithine-carbamoyltransferase	unknown	unknown	gnl\|CDD\|234835
NZ_CP051183.1\|WP_007017525.1\|1425507_1426548_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133039
NZ_CP051183.1\|WP_007017542.1\|1443974_1444904_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP051183.1\|WP_040297702.1\|1423988_1425506_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240533
NZ_CP051183.1\|WP_165837028.1\|1428058_1429033_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377422
NZ_CP051183.1\|WP_007017528.1\|1429034_1429655_+\|haloacid-dehalogenase-like-hydrolase	unknown	unknown	gnl\|CDD\|319796
NZ_CP051183.1\|WP_007017526.1\|1426686_1427796_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NZ_CP051183.1\|WP_007017540.1\|1441645_1443328_+\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|381099
NZ_CP051183.1\|WP_007017537.1\|1439438_1440836_+\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|270371
NZ_CP051183.1\|WP_007017529.1\|1429658_1430501_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_007017533.1\|1434724_1435903_-\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|235596
NZ_CP051183.1\|WP_007017538.1\|1440801_1441221_-\|YbaN-family-protein	unknown	unknown	gnl\|CDD\|377291
NZ_CP051183.1\|WP_040297673.1\|1432960_1434352_+\|O-antigen-ligase-family-protein	unknown	unknown	gnl\|CDD\|225844
NZ_CP051183.1\|WP_007017536.1\|1438915_1439242_+\|Grx4-family-monothiol-glutaredoxin	unknown	unknown	gnl\|CDD\|188046
NZ_CP051183.1\|WP_083771902.1\|1422736_1423999_+\|polysaccharide-pyruvyl-transferase-family-protein	unknown	unknown	gnl\|CDD\|377253
NZ_CP051183.1\|WP_040297705.1\|1437136_1438306_-\|aspartate-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|235056

Protein	Function_ID	Function_description	E-value
NZ_CP051183.1\|WP_007017541.1\|1443334_1443910_-\|YecA-family-protein	gnl\|CDD\|377099	pfam03695, UPF0149, Uncharacterized protein family (UPF0149). The protein in this family are about 190 amino acids long. The function of these proteins is unknown.	4.05493e-13
NZ_CP051183.1\|WP_007017530.1\|1430516_1431311_+\|glycosyltransferase	gnl\|CDD\|133038	cd04195, GT2_AmsE_like, GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis. AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.	1.15797e-90
NZ_CP051183.1\|WP_007017539.1\|1441334_1441637_+\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	2.58904e-19
NZ_CP051183.1\|WP_007017531.1\|1431414_1432725_-\|sugar-transferase	gnl\|CDD\|274398	TIGR03025, EPS_sugtrans, exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase. Members of this family are generally found near other genes involved in the biosynthesis of a variety of exopolysaccharides. These proteins consist of two fused domains, an N-terminal hydrophobic domain of generally low conservation and a highly conserved C-terminal sugar transferase domain (pfam02397). Characterized and partially characterized members of this subfamily include Salmonella WbaP (originally RfbP), E. coli WcaJ, Methylobacillus EpsB, Xanthomonas GumD, Vibrio CpsA, Erwinia AmsG, Group B Streptococcus CpsE (originally CpsD), and Streptococcus suis Cps2E. Each of these is believed to act in transferring the sugar from, for instance, UDP-glucose or UDP-galactose, to a lipid carrier such as undecaprenyl phosphate as the first (priming) step in the synthesis of an oligosaccharide "block". This function is encoded in the C-terminal domain. The liposaccharide is believed to be subsequently transferred through a "flippase" function from the cytoplasmic to the periplasmic face of the inner membrane by the N-terminal domain. Certain closely related transferase enzymes, such as Sinorhizobium ExoY and Lactococcus EpsD, lack the N-terminal domain and are not found by this model.	3.78904e-98
NZ_CP051183.1\|WP_133308465.1\|1436196_1437111_-\|ornithine-carbamoyltransferase	gnl\|CDD\|234835	PRK00779, PRK00779, ornithine carbamoyltransferase; Provisional.	0
NZ_CP051183.1\|WP_007017525.1\|1425507_1426548_+\|glycosyltransferase	gnl\|CDD\|133039	cd04196, GT_2_like_d, Subfamily of Glycosyltransferase Family GT2 of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	2.24248e-19
NZ_CP051183.1\|WP_007017542.1\|1443974_1444904_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.93186e-36
NZ_CP051183.1\|WP_040297702.1\|1423988_1425506_+\|hypothetical-protein	gnl\|CDD\|240533	cd13128, MATE_Wzx_like, Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	7.69716e-25
NZ_CP051183.1\|WP_007017528.1\|1429034_1429655_+\|haloacid-dehalogenase-like-hydrolase	gnl\|CDD\|319796	cd02612, HAD_PGPPase, phosphatidylglycerol-phosphate phosphatase, similar to Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C. This family includes Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C, PgpC (previously named yfhB) which catalyzes the dephosphorylation of phosphatidylglycerol-phosphate (PGP) to phosphatidylglycerol (PG). This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	7.58764e-12
NZ_CP051183.1\|WP_007017526.1\|1426686_1427796_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	2.53668e-36
NZ_CP051183.1\|WP_007017540.1\|1441645_1443328_+\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|381099	cd17546, REC_hyHK_CKI1_RcsC-like, phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC. This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	3.04376e-37
NZ_CP051183.1\|WP_007017537.1\|1439438_1440836_+\|OmpA-family-protein	gnl\|CDD\|270371	cd13653, PBP2_phosphate_like_1, Substrate binding domain of putative ABC-type phosphate transporter, a member of the type 2 periplasmic binding fold superfamily. This subfamily contains uncharacterized phosphate binding domains found in PstS proteins that serve as initial receptors in the ABC transport of phosphate in eubacteria and archaea. After binding the ligand, PstS interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The PstS proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	4.77265e-70
NZ_CP051183.1\|WP_165837028.1\|1428058_1429033_+\|hypothetical-protein	gnl\|CDD\|377422	pfam04932, Wzy_C, O-Antigen ligase. This group of bacterial proteins is involved in the synthesis of O-antigen, a lipopolysaccharide found in the outer membrane in gram-negative bacteria. This family includes O-antigen ligases such as E. coli RfaL.	1.55229e-05
NZ_CP051183.1\|WP_007017533.1\|1434724_1435903_-\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|235596	PRK05764, PRK05764, aspartate aminotransferase; Provisional.	0
NZ_CP051183.1\|WP_007017538.1\|1440801_1441221_-\|YbaN-family-protein	gnl\|CDD\|377291	pfam04304, DUF454, Protein of unknown function (DUF454). Predicted membrane protein.	1.45496e-49
NZ_CP051183.1\|WP_040297673.1\|1432960_1434352_+\|O-antigen-ligase-family-protein	gnl\|CDD\|225844	COG3307, RfaL, Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane].	1.80117e-11
NZ_CP051183.1\|WP_007017536.1\|1438915_1439242_+\|Grx4-family-monothiol-glutaredoxin	gnl\|CDD\|188046	TIGR00365, TIGR00365, monothiol glutaredoxin, Grx4 family. The gene for the member of this glutaredoxin family in E. coli, originally designated ydhD, is now designated grxD. Its protein, Grx4, is a monothiol glutaredoxin similar to Grx5 of yeast, which is involved in iron-sulfur cluster formation. [Energy metabolism, Electron transport].	2.25164e-65
NZ_CP051183.1\|WP_083771902.1\|1422736_1423999_+\|polysaccharide-pyruvyl-transferase-family-protein	gnl\|CDD\|377253	pfam04230, PS_pyruv_trans, Polysaccharide pyruvyl transferase. Pyruvyl-transferases involved in peptidoglycan-associated polymer biosynthesis. CsaB in Bacillus anthracis is necessary for the non-covalent anchoring of proteins containing an SLH (S-layer homology) domain to peptidoglycan-associated pyruvylated polysaccharides. WcaK and AmsJ are involved in the biosynthesis of colanic acid in Escherichia coli and of amylovoran in Erwinia amylovora.	7.39975e-24
NZ_CP051183.1\|WP_040297705.1\|1437136_1438306_-\|aspartate-aminotransferase-family-protein	gnl\|CDD\|235056	PRK02627, PRK02627, acetylornithine aminotransferase; Provisional.	0

>NZ_CP051183.1|WP_040297673.1|1432960_1434352_+|O-antigen-ligase-family-protein
MTLVCYSARAKLVYLKIWVTMLATAMGSFISLRNFVFSLYAVFFITLLVLPIVPKGIALLLLLVGIVGFAVYRGKLLIGFSPEERLLIWVFSAFTFISFISFLVFPYSRMSHYRMEDYATFMLILPMFLLLRQWRFKLNTIVVLFSFVATLLGVVSLLQLWSMQSGSGYFMTFDNPMAQFWNRPSGVVNPMRYAAISLIFFAFALNALVFVKRQSALIKTLLFVAMISAGIACALTQVRGAWLAFFALVFTYGCAFFYLGYRKRVVAFFAVAIIVVVSVAQFDFVEQRIHKTERAFEMYMEGNSGSSLGARLDMFKTAWWLINERPWFGHGLNSYSANATEIRENTPGMNPEVGRWHNPHNEILNATVEKGVIGLISMLLLFVAPGLLFLKAFLVNRGTGSVAYLSFCGISVLIVYFVAGLSVALFEHDIFNHFYVLTVLFLASQVHSHSSCSTREERKNVEL
>NZ_CP051183.1|WP_007017531.1|1431414_1432725_-|sugar-transferase
MHISNISNDAQILPLIQKPYTQSKVNTHRSKILLVRSLLAVACFSTLYAPFINSNVSSAALNSIIACMMTFIGTTYAMTKLSRYPGNSSLMSLPSLVLIHVTIAALIFISFRLEYSRLVLSIGILSVPITLFVQHHLIKRLTQASTYLVTPFGCFQSLKSNSHNQFILLSTPGFGENNIKHIDGVLFDQHEKLDGHWQQFLASSANRNIPLYDTTEVYESINGKSPLDHLPELSSGSLKPHWLYRSTKRILESLLILVTSPAWLSLVLFTALLIKLESKGPAFFIQRRVGQGGKEFSMVKLRSMRTDSEANGAQFAGEDDPRITKIGKFIRKVRIDEIPQFFNVLKGEMALIGPRPEQASFVKEFEEKIPLYSMRHVVKPGITGWAQVTHGYADDEESTKEKLAHDFYYVKNISLWLDIMVVFKTIKTMLIGFGAR
>NZ_CP051183.1|WP_007017530.1|1430516_1431311_+|glycosyltransferase
MNFSVLMSVYIKETSENLAECLDSLCRQSVKPNQVVLVEDGPISDSLHEIIEEYRQTLNIHSVTLEENQGLAKALNEGLKFCEYDLVARMDSDDISLPSRFEKQLDFMEQNPNIDASSGYIDEFDASGKVVSTRKLPILPGDVKIFAKKRSPLSHPATIFRKQAVLSVGGYPELYPEDYLLWVKMIINGSNLANIPEVLLKMRTDQAFITRRGYEFLKGEIKIYQYMRAEGFISYFEYCKIILIRSALRLSPNFLKVMFYKFAR
>NZ_CP051183.1|WP_007017529.1|1429658_1430501_+|hypothetical-protein
MPYYTVIPYAYFLKTRLIGRFQRLSWCFIYFVPSILLFFTFQESLSYAGVFNCVLGILIINYIYENGYLQNDVKTVQNEANPTMRLELATLKKLNLYWGRLISLRVFILAALLGLYYLIDLDLFKTLYLVFVSMVLQALYLVYNSCRGRINLFLILPLSYIRFYGFILPFVPVRESFEFLCFTIILYPLSKTLEFSKQEKFSLDLLSKAVGNVDVFRIKYYFFVVLLLLIFVLVGANGNRIYAVIAFYYLVYRTMGFLLITRKQSILREFETLSKSDYRK
>NZ_CP051183.1|WP_007017528.1|1429034_1429655_+|haloacid-dehalogenase-like-hydrolase
MSIFDICGTLYSCNTTFEFCKWRERRLVYRSLLWLTKTLPLKAGNRLIEKFFAIDLIRVLHLRTLKGCSESEIEISARRFVKEVLADFKVLPVHQILESKDLSSVVLVSATIEPVAKAIAEYLGVPSYLASTLCIKKGRYDGEIKNDLLGNKHSLFKGVDIDLVVTDNKSDYLLCKQAREVVIVSKRANMQYWKEKSLTNLSLIEV
>NZ_CP051183.1|WP_165837028.1|1428058_1429033_+|hypothetical-protein
MLIIFAFSLVFVSNIPLFLRHPNIVLFIHALLFSLSILIYLGITHYYKGSDFYHLFHSLESRVDVANTWYSFVFPEYGGSILRFNGYNLDPNVWGVYALFAFWFLVVLVCIAREEGYLYSKKLFLFTMVLSVISLVLTFSRGTYVAFFLSLFVYFSLTPSWIKKFKFIFFSFVFVSFIMFLYVNEATVKDFVDLKLFGEDVGDNPRILKWSFYLDRIWSSDLHEFLFGVGLIDLFDWFKGTTMHNTYLQIFLSFGLIGFFIFLLVFFLAVLGCIRSTSKELLSINFAMLSAISASVFFVDMMYSPVLWIGLAFPTMASTVLKES
>NZ_CP051183.1|WP_007017526.1|1426686_1427796_+|glycosyltransferase-family-4-protein
MKVILFSHEFPPYIGGVGRIGYDLLQLYTRTVGVEASLVTRSKPTPKLINRVKVNRVFTLPKIWFLNYALFYFFNRRLFREADVIYLNEAAPTIAAGMFFSKSDLSKCVIIAHGLEVEGVINSKQLVHRVLGLSRFYKRAVRISKKVVALSEAMRAKMCRALPSDYRRFIDVAYLGIDPEIFHYKPTLERDQRFQSVVESKVIGTCSRLIWQKGYKEMADTFAMAHKKDSSLLWYIAGDGEDALDIKDYIKFLGLENSVTFLGAFDYTELSSFYSFIDIFMLLSNYDEVFPLVYLEAQACGARSIGRNKGGTVEVVDLNTGCLVDDNIDAASFILSCPKNFDRKKVIEFTENFIIRENFKKWRDICEGL
>NZ_CP051183.1|WP_007017525.1|1425507_1426548_+|glycosyltransferase
MRDLRTEEEIISNWKNGIDKPVVSVCCLTFNHEPYIEDALEGFLIQETDFPFEILIHDDASEDNTANIVRRYQARYPNIIKPIYQTENKYSKGIKINLVYNFSRAKGEYIALCEGDDFWVASDKLKEQITLMKQYPHINISFHPVYQVEGFEFSKAKTLCDYSDVIRQYSPEEVILGGGIFMPTNSLMVKTAILKNLPEWFSTHAPVGDMYIQMIASLGGGAIYMPQKNGAYRTNIPGSWSSMHIKMECQKIEEYANNHIYCFTAFGAENVKFKNEILRALAFELVSCAWNSMKNNCDELAKSLVEKSTSYSECKYINFNQAVLVIFKRNFKILRFLLKLKNRIIA
>NZ_CP051183.1|WP_040297702.1|1423988_1425506_+|hypothetical-protein
MINSNSLRKNTLANYIGQAYMMLIGIVVTPLYLQHLGAEAYGLVGFFALMQAWMNLLDMGLGPTLGRQAAYARGQVEGFETFKRLLKSFEVIFFVLAVIIVFAIYILSDWIAISWIKSESIAIETLVYCVVLMGVMIGLRWFSGLYRSGINGLEDQVWLNVANIILTSLKFLGALCLLAFISQDIRHFFEYQVLIGLIELAAFSIRFYSILPVTKTRTPLVAFYWSVVKDVAPFAVGIAYTAGTWVLITQTDKLILSGVLSLAEFGYFSMISLVAGGIVMLSGPISQAIMPRLTMLYSQDNKNELLSLYSDASQLVTVTSLSVSLMIGLYAEPLIYAWAGDREAAEWGAGVLIWFALGNGVLAIAAFQYYLQSAFGQLRLHVIGSTLSAIIQVPLIFYAATNYGAQGAGITWFAFRTIWFLCWTPVVHRQFIPGFHLRWMLKGILPIAIVTMCVALAMHFLITLDLNQNRLDLFAKLISLGLLLLSVSALSSSAIRQRIFRLLKN
>NZ_CP051183.1|WP_083771902.1|1422736_1423999_+|polysaccharide-pyruvyl-transferase-family-protein
MEFGNIGNYYIIEPFMRELHRVFPNASIKTTMQMSERFCEGERVTLLPMNLYYGWTGNDLEIAQEELKLAEAYAESGCLKKETPYIQEVMQADLVIDFSGDIWGDNANFLGDDRFLVGLIKDRVAQLLGKKVVMLAGSPGPFSNKDNLPFAREVFKCFDLITNREPISIDLLKKDGFDTSKTLSLACPAFLFDRAEGADVDKLLSEEGLRNKDKPIVGFILCGWNFEVGPFDKENRDDEDFTKFAETVEYLTEELGVRVCLMSHSNGFDIPPAPFKLKHGRDYVITKQLEKILDERSISKDFFTLNGVYDTWTTKAIINEFDMLVSGRVHAAVSGLSQSVPTVIIDYGHEPKAHKLVGFAKVAQVEEYVADPCSLTDLKTKVFKCYSQREQYKESLNKRIPVVKKLARQNFEVLKSVLDQ
>NZ_CP051183.1|WP_007017533.1|1434724_1435903_-|pyridoxal-phosphate-dependent-aminotransferase
MDLKLSNRVQSIKPSPTLAVTNRAAELRAAGKDIIGLGAGEPDFDTPEHIKDAAKQAMDNGFTKYTAVDGTPDLKKAIIAKFKNDNGLNYEANQILVSCGGKQSFFNLSLALLNPGDEVVIPAPYWVSYPDMVKIAEGVPVIIETDASARFKITPEQLDNAITDKTKLVVLNSPSNPSGMAYTKAEFEALGDVLRKYPNVLIATDDMYEHILWTEEDFNNIVTVNPDLYERTIVLNGVSKAYSMTGWRIGYAAGPQPLIASMKKIQSQSTSSPTSIAQVAAQAALEGNQQCVKDMVTVFKKRHDFMVDALNEIDGIECLNGDGTFYLFPSFKGAQAKLNCETDTDLAEKLLEAGVALVPGSAFGTPGHMRISFATSDSNLEQSIERLKKALG
>NZ_CP051183.1|WP_133308465.1|1436196_1437111_-|ornithine-carbamoyltransferase
MQVKTPRHLLTLLDLTPAELQHITSRATELKRMHRAGEIYEPLKNKVLGMIFEKSSTRTRVSFEAGIAQLGGSAIFLSPRDTQLGRGEPIEDSAKVLSRMCDIIMIRTFGHDIVENFSANSRVPVINALTDDFHPCQLLADMQTYQEHRGSIKGKTVVWVGDGNNMCHSYINAAKQFDFNLVVNCPEGFEPMAELMEANKDRVKIIRDTKEAAKGAHLLVTDVWASMGQEEEQKEREKVFKSYQVSPAVMDLADKDALFMHCLPAHRGEEISHDMLDDPRSVVWDEAENRLHAQKALMEFLLSA
>NZ_CP051183.1|WP_040297705.1|1437136_1438306_-|aspartate-aminotransferase-family-protein
MNTYGRLPVTFSHAKGAYVYDDKGNSYLDALSGIAVCGLGHAHPAVTQAICEQADNLVHVSNLYGINRQNELAEKLTKISGMDNVFFSNSGAEANEAAIKIARKYGNEKGVELPTILVAENAFHGRTMATLTATGNKNAQAGFGPLLDGFERVPYNDLEAAKKAIEKNPNIVAVLIEPVQGEGGVTAGLDDYLTGLRKLCDQNDLLYMLDEIQTGNGRTGQYFAYQHYNWKPDVVTTAKGLGNGVPIGACLAKGKAAEVLQPGSHGSTYGGNPLACSAGCAVIDTITSANLCERVQALGERIRHQLQSHLDNQQVTEYRGKGLMIGIVLNTDEACGAIMKMALDEGLLLNVTAGNVVRLLPPFILTDEQADTVAEKTANVIKAFLAEKQ
>NZ_CP051183.1|WP_007017536.1|1438915_1439242_+|Grx4-family-monothiol-glutaredoxin
MSDIMDQIKEQIESNDVLLYMKGNPNQPQCGFSARAVQALMECGKRFAYVDVLSNPDIRSNLPIYANWPTFPQLWVKGELVGGCDIITEMGANGELKQIIDQAVPDEA
>NZ_CP051183.1|WP_007017537.1|1439438_1440836_+|OmpA-family-protein
MKYSLLFLFSWIFSSFVFASLSVEQEARLNQSLSEILVKPAPFEALVGSSEKTLFSIQGSNTIGGSLAPNLAMEYLKAKGAKNVMIRPLPTANEKLITGDLPDQGKSVNIFIAAHGSSTGFKKLVDGQAQIWAASRPVKDKEVKAAQPLANLRAPESEHVLGIDGLAIIVNPDNPVSQLSKEQVGLIYSGQISNWSQLGGQDRAITLYARDNKSGTWDSFKSMVLAKRFTLSSDAFRYESSEDLVDSVLTDPSGIGFVGLGFVKEAKLVAISDGPAQPFQPSIMTVATEDYALSRRLFLYTPGASKNKYVNEFLAFAEGIQGQRVVNAEGYISQNVEAMDVALPDELPQDYLAMVKNAKRLSINFRFKEGSAKLDNKALKDIQRLAYYMTEHPQQELVLIGFGDRRKNKERSKLLSKLRAMAVRRELSRLGIYPDEAEGYGEYNPVAAFEQSAATKNRRVEVWLR
>NZ_CP051183.1|WP_007017538.1|1440801_1441221_-|YbaN-family-protein
MNKRILHYFLIGFGWISVVLGVVGIFLPLLPTTPFLLLAAACFVRSSPRFYNWLVQHPKLGNYIIHYLEGNGIPLRGKIMAITMIWVTMGISIIWVVPVWWVKWVLAAIGLSVSIYIARQPTLNSDLPAIEARPQHDDS
>NZ_CP051183.1|WP_007017539.1|1441334_1441637_+|STAS-domain-containing-protein
MSSVIVDEQGSEVIISINGRFDFNILQEFRDAYSSLESSSKAFVVDLGKTEYIDSSALGMLLNMKNHLGSDDQGIEIRNCQPNLKKIFSIAHFDKKFLFK
>NZ_CP051183.1|WP_007017540.1|1441645_1443328_+|SpoIIE-family-protein-phosphatase
MHILVVDDQVTNREILKWLLEDEGHQVSEAQNGEEAVNEFKSGDFDLVLMDVIMPIMDGLEATKRIKEIGQEDNYVPVIFLTALDDAKALKDCLDSGGDDFLSKPYNEVILKAKIHAHLRIRELTRDISEKNAVLTHYNSLWQREQNIVSHIFNKALEHNIKNTRSLRTHIQPASTFNGDIVLSAPSLTGGLYVFVGDFTGHGLGASIGTLPLVHAFNELAIRHLSVGEIAYEFNRMLRSMLPDYMFCCATIVELNESGDSVQLWTGGLPDGYLISESEGVVDTLCSENMPLGIESDERFNKGFQVKHLKSDQKLIIITDGIIEAESQRGDFFGEKRLQQCLNQTERDSFKHVLKTLKAYTAEAKQSDDITLVEVNAGKVELEEGQHDLVNHSVVQDGIVWSMNCTLSIQDLQRGQPVEEVMSILGAQSVIRPYRDLVGLLISELYSNALEHGILGLDSALKQTTEGFQSYYQQREQHLASLEEAHLKLMIQVINGADHRLLNIRMTDSGNGFDVDKIFDASHEDSFGRGIGLIKRLCSRVEYLDGGSTVDVDFPLLLKS
>NZ_CP051183.1|WP_007017541.1|1443334_1443910_-|YecA-family-protein
MSTLAALDEDQLETLALFLEEQSEVADGLDFFALHGLLTANAVALHRLDWLALEPIVFAEPVKWSSDQDKQTILSLIDTLQKEIIELVESGQSFPVPCDLNVEADEDGEAAPLENWCVGFIMLSMEDEKSWYGEHEEQAAELLFPIVYASGVNAEAPEFAEIDEDDRLSKQVCADIPDNVVDLFLLYHGDK
>NZ_CP051183.1|WP_007017542.1|1443974_1444904_+|LysR-family-transcriptional-regulator
MRGPRVTLEQWRTLQAVIDHGGYAQAAEALHKSQSSISYTVGKLQEQLGMELLHIEGRKAVLTSAGEALLQRSRHLIEHAMELEAVAASLEQGWEAEVRLAMDAIFPKSILINAFKDFLPKSSNTKVVLREEVLSGAAEALLEKKVELSITPVVPPGFMGEKLMDIQFIAVAHPDHELQKLGRPVTMKDLESQMHIVIKDSAIKQNRDSGWLGSDLRWTVSNFESARALLASGLGFSWLPTHEACDLINEGNVKPLELDTDYRKQGSLYLVYASKEIAGPATNLLADCIQTCTKAYEATHPALEELMAK

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Crispr_ID: NZ_CP051183_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP051183_7

2236361-2236464

Orphan

Consensus_repeat	Method
TTGCGGGGGTCGCTGGGGCTCCGGCCGCACTACT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP051183_7

>merge|NZ_CP051183|7|2236361-2236464|CRISPRCasFinder
TTGCGGGGGTCGCTGGGGCTCCGGCCGCACTACTTTAGTTTTTGAAAACCGGGCAGATTTCGAAAGCCTGTTGCGGGGGTCGCTGGGGCTCCGGCCGCACTACT

>NZ_CP051183|7|7|2236361-2236464|CRISPRCasFinder
TTGCGGGGGTCGCTGGGGCTCCGGCCGCACTACT	TTAGTTTTTGAAAACCGGGCAGATTTCGAAAGCCTG
TTGCGGGGGTCGCTGGGGCTCCGGCCGCACTACT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP051183.1\|WP_007017255.1\|2242231_2243779_+\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910
NZ_CP051183.1\|WP_040297625.1\|2236867_2237992_-\|Na/Pi-cotransporter-family-protein	unknown	unknown	gnl\|CDD\|162157
NZ_CP051183.1\|WP_083771896.1\|2231623_2232094_+\|2Fe-2S-ferredoxin-like-protein	unknown	unknown	gnl\|CDD\|182668
NZ_CP051183.1\|WP_007017254.1\|2240638_2242120_-\|glycerol-kinase-GlpK	unknown	unknown	gnl\|CDD\|198361
NZ_CP051183.1\|WP_007017252.1\|2238423_2239344_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_007017245.1\|2230477_2231608_+\|ribonucleotide-diphosphate-reductase-subunit-beta	unknown	unknown	gnl\|CDD\|181647
NZ_CP051183.1\|WP_007017248.1\|2232739_2233381_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_007017247.1\|2232121_2232589_+\|thioredoxin-dependent-thiol-peroxidase	unknown	unknown	gnl\|CDD\|181857
NZ_CP051183.1\|WP_007017258.1\|2245674_2245884_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_007017250.1\|2236524_2236854_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_007017243.1\|2226922_2227654_-\|response-regulator	unknown	unknown	gnl\|CDD\|236738
NZ_CP051183.1\|WP_007017244.1\|2228133_2230404_+\|ribonucleoside-diphosphate-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|181649
NZ_CP051183.1\|WP_007017259.1\|2245921_2246752_-\|pirin-family-protein	unknown	unknown	gnl\|CDD\|224655
NZ_CP051183.1\|WP_007017253.1\|2239375_2240503_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NZ_CP051183.1\|WP_007017240.1\|2222427_2224281_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP051183.1\|WP_007017241.1\|2224438_2225356_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176132
NZ_CP051183.1\|WP_007017249.1\|2233816_2235778_-\|oleate-hydratase	unknown	unknown	gnl\|CDD\|237575
NZ_CP051183.1\|WP_007017242.1\|2225530_2226826_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|236724
NZ_CP051183.1\|WP_040297554.1\|2243847_2244360_+\|glycine-cleavage-system-protein-R	unknown	unknown	gnl\|CDD\|225337
NZ_CP051183.1\|WP_007017257.1\|2244377_2245490_-\|ATP-NAD-kinase-family-protein	unknown	unknown	gnl\|CDD\|225740

Protein	Function_ID	Function_description	E-value
NZ_CP051183.1\|WP_007017255.1\|2242231_2243779_+\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	1.09588e-59
NZ_CP051183.1\|WP_040297625.1\|2236867_2237992_-\|Na/Pi-cotransporter-family-protein	gnl\|CDD\|162157	TIGR01013, Sodium-dependent_phosphate_transport_protein, Phosphate:Na+ Symporter (PNaS) Family. [Transport and binding proteins, Cations and iron carrying compounds].	3.29636e-38
NZ_CP051183.1\|WP_083771896.1\|2231623_2232094_+\|2Fe-2S-ferredoxin-like-protein	gnl\|CDD\|182668	PRK10713, PRK10713, 2Fe-2S ferredoxin-like protein.	3.65438e-29
NZ_CP051183.1\|WP_007017254.1\|2240638_2242120_-\|glycerol-kinase-GlpK	gnl\|CDD\|198361	cd07786, FGGY_EcGK_like, Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases. This subgroup is composed of mostly bacterial and archaeal glycerol kinases (GK), including the well characterized proteins from Escherichia coli (EcGK), Thermococcus kodakaraensis (TkGK), and Enterococcus casseliflavus (EnGK). GKs contain two large domains separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The high affinity ATP binding site of EcGK is created only by a substrate-induced conformational change, which is initiated by protein-protein interactions through complex formation with enzyme IIAGlc (also known as IIIGlc), the glucose-specific phosphocarrier protein of the phosphotransferase system (PTS). EcGK exists in a dimer-tetramer equilibrium. IIAGlc binds to both EcGK dimer and tetramer, and inhibits the uptake and subsequent metabolism of glycerol and maltose. Another well-known allosteric regulator of EcGK is fructose 1,6-bisphosphate (FBP), which binds to the EcGK tetramer and plays an essential role in the stabilization of the inactive tetrameric form. EcGK requires Mg2+ for its enzymatic activity. Members in this subgroup belong to the FGGY family of carbohydrate kinases.	0
NZ_CP051183.1\|WP_007017245.1\|2230477_2231608_+\|ribonucleotide-diphosphate-reductase-subunit-beta	gnl\|CDD\|181647	PRK09101, nrdB, ribonucleotide-diphosphate reductase subunit beta; Reviewed.	0
NZ_CP051183.1\|WP_007017247.1\|2232121_2232589_+\|thioredoxin-dependent-thiol-peroxidase	gnl\|CDD\|181857	PRK09437, bcp, thioredoxin-dependent thiol peroxidase; Reviewed.	1.55981e-90
NZ_CP051183.1\|WP_007017253.1\|2239375_2240503_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	6.53433e-63
NZ_CP051183.1\|WP_007017243.1\|2226922_2227654_-\|response-regulator	gnl\|CDD\|236738	PRK10701, PRK10701, DNA-binding transcriptional regulator RstA; Provisional.	2.5276e-85
NZ_CP051183.1\|WP_007017244.1\|2228133_2230404_+\|ribonucleoside-diphosphate-reductase-subunit-alpha	gnl\|CDD\|181649	PRK09103, PRK09103, ribonucleoside-diphosphate reductase subunit alpha.	0
NZ_CP051183.1\|WP_007017259.1\|2245921_2246752_-\|pirin-family-protein	gnl\|CDD\|224655	COG1741, COG1741, Pirin-related protein [General function prediction only].	5.38843e-64
NZ_CP051183.1\|WP_007017240.1\|2222427_2224281_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	4.58102e-156
NZ_CP051183.1\|WP_007017241.1\|2224438_2225356_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176132	cd08441, PBP2_MetR, The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold. MetR, a member of the LysR family, is a positive regulator for the metA, metE, metF, and metH genes. The sulfur-containing amino acid methionine is the universal initiator of protein synthesis in all known organisms and its derivative S-adenosylmethionine (SAM) and autoinducer-2 (AI-2) are involved in various cellular processes. SAM plays a central role as methyl donor in methylation reactions, which are essential for the biosynthesis of phospholipids, proteins, DNA and RNA. The interspecies signaling molecule AI-2 is involved in cell-cell communication process (quorum sensing) and gene regulation in bacteria. Although methionine biosynthetic enzymes and metabolic pathways are well conserved in bacteria, the regulation of methionine biosynthesis involves various regulatory mechanisms. In Escherichia coli and Salmonella enterica serovar Typhimurium, MetJ and MetR regulate the expression of methionine biosynthetic genes. The MetJ repressor negatively regulates the E. coli met genes, except for metH. Several of these genes are also under the positive control of MetR with homocysteine as a co-inducer. In Bacillus subtilis, the met genes are controlled by S-box termination-antitermination system. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.23531e-120
NZ_CP051183.1\|WP_007017249.1\|2233816_2235778_-\|oleate-hydratase	gnl\|CDD\|237575	PRK13977, PRK13977, myosin-cross-reactive antigen; Provisional.	0
NZ_CP051183.1\|WP_007017242.1\|2225530_2226826_-\|HAMP-domain-containing-protein	gnl\|CDD\|236724	PRK10604, PRK10604, sensor protein RstB; Provisional.	2.20493e-66
NZ_CP051183.1\|WP_040297554.1\|2243847_2244360_+\|glycine-cleavage-system-protein-R	gnl\|CDD\|225337	COG2716, GcvR, Glycine cleavage system regulatory protein [Amino acid transport and metabolism].	1.88179e-32
NZ_CP051183.1\|WP_007017257.1\|2244377_2245490_-\|ATP-NAD-kinase-family-protein	gnl\|CDD\|225740	COG3199, COG3199, Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only].	2.05396e-80

>NZ_CP051183.1|WP_007017249.1|2233816_2235778_-|oleate-hydratase
MTKQSLKRSDLHRKFVEKDATAEFWHNSPSNTLPPPDMLSPYSRNKPLKTEDIENRKAHIIGAGIAGLAAAFYLIRDGHMPAENIFIFTSEDVEGGSLDGAGNVQEGYIVRGGREMNWNYDNLWDMFQDVPAVELPTGFSVLDEYRLLNDHDSNYSKARLLHKNGQIKDFSNFGLSKRHQWELISLLLKRKEELDDITVESYFSSSFLETNFWTFWRTMFAFQNWHSVLEMKLYMHRFLDAIDGLNDMSALVFPKYNQYETFVEPLTKMLKEQGVNFIRNQRICDLEIQDNTDAKTITGLITATGEVLAVDECDLVFALTGSMTEGTAYGDMDTVPELQRTQGYPGTNSDWVLWKNLAEKSTVFGNPNTFVGDTSRSMWESATLTCHHSPLVDKLISLSVNDPFSGKTATGGICTITDSNWLMSCTINRQPHFRNQPDDVLVVWVYALLMDKQGNKVHKTMPECTGKEILEELCHHLGLEDQFELIAENTKVRTALMPYITAEFMPRAKGDRPRIVPEGFTNLGLVGQFVETNNDVVFTMESSVRTARVAVYSLLNLSKVVPDISPTQYDVRNMLKGARALNNGKPFIGERLLHRLLDKTYYAHILPPLPEPEESKLESLEAEIKQLPAKLSVMYRSVSDQVHRLRDKIINKK
>NZ_CP051183.1|WP_007017248.1|2232739_2233381_+|hypothetical-protein
MANQTNQYNFDSWAEFLTINMAENIRRCERSQEKLKKLHIELDPHDYKPTRFKAILDSDIVATHTNTSADSEDGYSTIKNFYHCPTALADQETSAKIGRDFIDAAQKQDSAFFDDAWLLTMDGCIPHLLTQFALRSMSKMMAEQLRFVGVDINDDFYVQFHVNDNTVSLTYDELVLALKRQMGFYLTNLKVKKMACEICFRHKENKVWFMSLP
>NZ_CP051183.1|WP_007017247.1|2232121_2232589_+|thioredoxin-dependent-thiol-peroxidase
MQKPDIGKVAPAFTTLNEKGEKVALKDFRGKKVVLYFYPKAMTPGCTSQACGLRDTKKELEKHNTIALGISPDAPSRLMKFIERDNLNFSLLSDEDHKIAEKYGVWGLKKFMGKEYDGIHRTTFIIDEDGKLINIMDKFKTKTHHEDVLAYLESL
>NZ_CP051183.1|WP_083771896.1|2231623_2232094_+|2Fe-2S-ferredoxin-like-protein
MKYKDASKQDSFHLDSPQPDEIQNENQDFQLESPAPEVESGAVQNELFLPEYDPESPIDDGQLEIVGFEKPAYAVAVDGIEKPLQFHYASSLLESLEAQGVQVPYQCREGYCGGCRTDLVEGEVAYLQEPMAWINEGEILPCCCVPKSPLKLKLKG
>NZ_CP051183.1|WP_007017245.1|2230477_2231608_+|ribonucleotide-diphosphate-reductase-subunit-beta
MSYQTFNRNTFDAFSQPMFFGENVNVSRYDTQKYKIFEQLIEKQLSFFWRPEEVDLSTDRKDFAALPEHEKHIFLSNLKYQTLLDSIQGRSPNVALLPIVSLPELETWIETWSFSETIHSRSYTHIIRNVISDPSKVFDDIVSNEYITKRAESVTKYYDDLIEGVTYYQNLGEGDHEINGETIHVSLRDLKRKLYLTMASVNVLEAIRFYVSFACSFAFAERTKMEGNAKIIKLIARDEALHLTGTQHMMQIWALGKDDPEMGEIANECKKQVIEIFREAAQQEKDWAEYLFKDGSMIGLNKDILCQYVEYITNQRLGAIGLDNIFETRQNPIPWINAWLVSDNVQVAPQEAEISSYLVGAIDSEVSLEDFSDIEL
>NZ_CP051183.1|WP_007017244.1|2228133_2230404_+|ribonucleoside-diphosphate-reductase-subunit-alpha
MSSTLHVTKRDGNRAPLDLDKIHKVLTWAAEGLENVSVSEVELRAQIQFSDGISTSDIHETLIKSAADLISENTPDYQYMAARLNIFHLRKKAYGQFEPPALYEHVAKLVDMDRYDRHLLEDYTKEEFDEMEGFIEHGRDLNFAYAAVKQLEGKYLAQNRVTGEVFESPQFLYVLIGACLFANYEKSNRMDYVRRFYDAVSTFKLSLPTPIMAGVRTPTRQFSSCVLIETDDSLDSINAAAGSIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPIWHLEVESLLVLKNNRGVEENRVRHLDYGVQINKLMYERLIKGGNITLFSPSDVPGLYDAFFEDQAKFEELYVKYEQDDSIRKQTIKAMELFSILLQERASTGRIYIQNVDHCNTHSPFNPEHAPIRQSNLCLEIALPTKPLKDINDKDGEIALCTLAAFNLGALENLDELEELSDIIVRALDNLLSYQDYPMAAAEIASESRRTLGVGVINYAYYLAKNGVKYSDGSANGLTHQTFEAIQYYLLKASNQLAKEVGACAKFNETTYSQGILPIDTYKKDLDKVCEEELRYDWEALRGEIKTHGLRNSTLTALMPSETSSQISNATNGIEPPRGYISIKASKDGILKQVVPEYQKLKNNYELLWNWPSNDGYLQLVGIMQKFVDQAISANTNYDPSRFEGGKVPMKLLMKDLLTTYKLGLKTLYYHNTRDGASDAQDDMADDCAGGACKI
>NZ_CP051183.1|WP_007017243.1|2226922_2227654_-|response-regulator
MQHTEESWHIMIVEDDERLSDLTRDYLVSNGMQVSVEADGARAVDRIKDEQPDLVILDLMLPGEDGLSVCRLVRPSYKGPILMLTARDDDLDQVLGLEMGADDYLTKPVRPRVLLARIRALLRRLKDNPSVAGQNVDGEESQTRVTFANLVVDNSMREAWLNDDPIELTSAEFDLLWLLSSNAGRVLSREEIFTALRGIEYDGQDRSIDVRVSRIRPKIGDDPVNPKRIKTVRSKGYLFVKEI
>NZ_CP051183.1|WP_007017242.1|2225530_2226826_-|HAMP-domain-containing-protein
MLLVSTLLASSLWTMSHLTSNEDASRALNHIHQHLETLNHTELHQRLSSPVYSHYSASIKLPALSKLEQARLKHFQYVAVADSSLVVFRLAGNGLLSMHWEQFWDAYMTLAEAEGIVPIERQPAFTSQRLFILILVVLVATGLFVYFLVSGFEMNLEQLQRASSRIANGHLNSRVKVDEEKKNTDPFSRLGFAFNRMANQIQRLMGVQREMIRAVSHELRTPVARMRFGIQMLEDSTDDQFVHKQLHAMDNDLQELDELVDEILTYARLEEGGPILEFERNNMLDLVHQIVEETRRRTDKVTIQAHSDTVNEARIFSDIEYRYLHRAVQNLVGNACRYAKSQVHIEYHCDEQVCRIDVEDDGEGIPEKDWERVFTPFTRLDDSRTRSSGGYGLGLSIVQRIIYWHGGQASVGRSRWGGAKMSLVWPQYREH
>NZ_CP051183.1|WP_007017241.1|2224438_2225356_+|LysR-family-transcriptional-regulator
MNIELRHLKTLLALDQTGSLVEAAAHIHLTQSALSHQLKELEGRLDQPLFYRKTKPVRFTPAGQRLLELAQAVIPQIESTERDLSRIRQGRKGRLNITIECHSCYDWLMPTLNEFRGHWPEVELDMLGGFHFDSIAKLKNGELDLVVTSDPKNDDEIAYLPLFKYQAMLIVAPEHELAQKTVIEPHDLSKETLITYPVDCSSLDIFQCFLTPAGIEPGHLRQVELTMMMVQLVASGRGVCCLPNWAIYDYVRQGFVTAKPLGRHGVFRTLYAAVRAEQAENAFIQDFKTIAQRVCHQHLEGIKPA
>NZ_CP051183.1|WP_007017240.1|2222427_2224281_-|ABC-transporter-ATP-binding-protein
MFSFFERLINPYPSQEPQQPPDTLWAFCRHYTKGMWVPLVIMTVLTACLAMFEVYLFGVLGDLVDWLVDKDPKTLFQDEGDRLVLIGLMLVVVMPLLVMVHAMIVHQTLLGNFPMSIRYLAHRYLLKQSLSFYQDEFAGRIATKVLQTSLALRESIMKLLNVMVYILVYFTSMVFVVAQADWRMAMPIFGWLALYIVAQWYFIPKLKDISTKQADARSDMTGRIVDTYTNIMTVKLFSHNARETQYAKDAMDGFMGTVYKQMRLAVGLNVSVHVINYFLVFAIGALGIYLWVNNAITAGAIAIAVSLSLRLNGMAQWIMWEVSSLFENIGTVADGMKTLSKPQSIQDKLDAKPLTISQGEIHLKHVRFAYEKANSQNNAIQDWVFDDLDLRIKPGEKVGVVGRSGAGKSTLVNLLLRFYDVQEGEILIDGQNIAEVKQESLRQHIAMVTQDTSLLHRSVRDNILYGRPDATESEMLEATKQAQAFDFVQSLSDVKGGRGFDAQVGERGVKLSGGQRQRIAIARVLLKDAPILILDEATSALDSEVEAAIQESLTDLMQGKTVIAIAHRLSTIAAMDRLIVMDQGRIVDEGTHEELLAREGIYRQLWSHQTGGFLGDE
>NZ_CP051183.1|WP_007017250.1|2236524_2236854_-|hypothetical-protein
MGKKRIKKLQAQVEEAREALRELEEKTERKILKAQHKQLDKLDPNKVEGKKESLLDVGEEAFQELKELSDSLINRIKSAIRRQDEEDKKEEDQQEKLEEKEKPEEKQDK
>NZ_CP051183.1|WP_040297625.1|2236867_2237992_-|Na/Pi-cotransporter-family-protein
MQSRLIKWMILLAGVYAILLSVGMVGSGFKWASGGSEGARELFAFATNPFVALLIGILATSLVQSSSTVTSVIVGLVAGGLPIEIAIPMVMGANVGTTITNTLVSLGHVRKKSEFKRAFAAATVHDFFNLIAVIIFLPLEIIFGILQKASEWATQYLIGADSMSIKGFNFIKPLTKPVIGEIKSWLTVLPEKAAAITLIVLGIVAIFVSITIIGRVLKSLMVGRAKRILHGAIGRGPVTGIFSGSVVTVLVQSSSTTTSLMVPLVGSGVFKPKDIYPFTLGANIGTTITALLAATGLSGAGAAVGLQIALVHLFYNVSAVLIIFALPFLRNVPLYLAERLSEVATRRHSLAALYVLTVFFVIPGLCVLLMSGLD
>NZ_CP051183.1|WP_007017252.1|2238423_2239344_+|hypothetical-protein
MEIHKLINSSLKFGSVLLLSLSLANAAHSTAYIRLHYGYYGSQHAFVEDEATQQSIMQSIDINLLTWRRKRVGYLSRGPRLQWIQAEQLTQVSATLPIYQWTPDHGAYFEYRYSQWQLDTNWSTSRLYLQDNGTAVSTGIGESRIESEQTQWQLYWLEGVNQEGPINRVGLSYLQQNTPASAEISGVTADLYDADFTGWGIQLGRIKHDRGLNFQWLLDIYNLQTDFSNSVTQHRATARGESEDLRLNLQLDWHYRYRIEPYWYWVPKVGSQLTYQTQSDTNPQIVKHDAFTSVDWYASLGLEITF
>NZ_CP051183.1|WP_007017253.1|2239375_2240503_-|GGDEF-domain-containing-protein
MLQSEKQAIRLRRAILANLGTLGNVVLCAFAAYLGYFVIEWPYVVSIAAVIWLGHCVMVVAILRQWNLRLKDASMTFPQMFWVAMGISVLMFFANDIRSLLLMAYLLILSFGAFRLRRTGFYLFTLFTVVSYGLSLLMIYRTRPDAINLVQEFFIFSGFVMVIVGFAFMGSEFSSLRQALGERHRQLKGAMSKIEELAITDELTGLYNRRHVMEILNQQRALANRSQYRFTVCFLDLDHFKKVNDQYGHPFGDKVLKRFASLVRTSLREVDIGARIGGEEFILILADTCQEDAHEVVRRMAQRWQQTLFEPHESLVMTLSAGITEFHPPETLEAMIERADELLYEAKRDGRNCVKIEQVDRQATLDLTFPDGDPA
>NZ_CP051183.1|WP_007017254.1|2240638_2242120_-|glycerol-kinase-GlpK
MSQFIMAIDQGTTSSRAIIFDQHGRIQAQAQAEFPQYFPNDGWVEHNAKEILEGVIQVSREVLQKSELAASDIAAIGITNQRETTVVWDRDTGEPVYNAIVWQDRRTARVCEELTLQGKENWVNKKTGLLLDPYFSATKLQWILNNVDGARERAQAGELAFGTIDSYLLWSLTGEHKTDVTNASRTMLFNIHELTWDNELLELFDVPSSVLPEVCASSEEFGYTREDILGAPVLVGGMVGDQQGALIGQACFHEGMAKSTYGTGCFLMQNTGTQPRTSHHRLLTTIAYQVGDTVHYALEGSIFMAGATIQWIRDGLKLIGHARETLDMAKQVGANNHVYMVPAFTGLGAPYWDPDARGAIMGLTRDTGIAEIVTAGLQSVCYQTRDLLEAMAKDKAVPTRIRVDGGMVVNDWVVQFLADILQLPIERPEITETTALGAAYLAAISAGQKTCLADVAELWQQERSFEPNMERAASDQLYDGWLDAVGRVRSHRD
>NZ_CP051183.1|WP_007017255.1|2242231_2243779_+|methyl-accepting-chemotaxis-protein
MKKNFPVTQKELDYDASKRIISSTNLKGITTHVNDDFIEISGFTADELLGKSHNVVRHPDMPPAAFKLLWDRIKAGKQWKGVVKNRCKNGDHYWVDAFVTPVKENGEVVSYESVRYKPSSEEIRRAEKTYKRINAGKAPIPKKSLLRTLPVGQIASVILGILAVYIASHYSPWLALLPVVALGFTQGIELKGIKTVLKKARTITDDDLAAYIFTGRVDDVGKILMAFEHMESQLITLRERMEDSTKPIQEASQVSKNAAENSLHKLNEQLDAATMFAAAFEEVTTQFDSISDSVTSTAERMQQADQDTQSSEQQMLKAKDTLESMAQTINQASSSVQELANHAESIHSFLEVIQSIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRSLANRTSDSTEEIRRIIASLRQGAQDTTAVMNQSQEQAHDNAEQMQITHQTLEQVKAAVQEINNQMATINHAVQEQRSGSSEINTHMETIRQNAQDNQHTAEDSRAAAEKVLKLVAEQHSIIERFR
>NZ_CP051183.1|WP_040297554.1|2243847_2244360_+|glycine-cleavage-system-protein-R
MSTFLIISIMTDDRPGIVDTLSGIVKQHSGNWLESRMSQLSGKFAGIVKVQISKQTADELSTALAELKQQGWIINVEQQDTENETAKANAKLSIVGNDRPGIVKDVAQVLASHAVNVLELNTAFESAAMSAEALFKTKAKVYIPQDKDFQDVADALEQLSNDLMVEIQEI
>NZ_CP051183.1|WP_007017257.1|2244377_2245490_-|ATP-NAD-kinase-family-protein
MFRLGLIINPLAGLGGSVALKGSDGVAELALSKGAIAKAQERAKIAFDVFSELKSDIQLITCGGAMGEQLAQSLAYDFEIAYTPSNPLATTADDTKRAASAIRDAGVDLLLFAGGDGTARDVCQIVEDAFPVLGIPAGVKIHSGVYGVTPSASGEVVKLLVNGELVDLKPQDVRDIDEDAFRQNQVKAKLFGEMLVPQAGQFVQSVKQGGVEQEDLVLDDIAAYLIQELEPDVLYLIGSGKTTQYFMNQLHLPSTLLGVDALCNEEVVAQDLTESDILKLLDDYSEVKVILSVIGGQGHILGRGNQQLSAKVIERIGRDNLKIIATKTKLKALEGRPLIVDSGSLELDRNLAGHMEVITGYQDLVLYPVQ
>NZ_CP051183.1|WP_007017258.1|2245674_2245884_+|hypothetical-protein
MSDAHKKAMLAVFAVLFLLLAIATGFVAIEIQHVSVTSILAITLVIIALDIHWVLNNQDNNDTNLSSEG
>NZ_CP051183.1|WP_007017259.1|2245921_2246752_-|pirin-family-protein
MRTVQTILSAMDAMDGAGVKIKRHSPIHHGLADPFIMLDEIRSDDKDDFIAGFPPHPHRGIETLTYMRVGGIRHEDNMGNVGEVLGGGVQWMRAGKGVIHGEMPLKEHDQMHGFQLWINLNSRNKMQPAEYRDVPKNEIKHVEIRRGMVHVIAGEWQLQGQTINGPLDRLEGNSHIIDIELEAGAEFQHEIEKGHHLVVAVYDGELMADKPIKTHQMALFNDDGRLELTTDSGAKALILHGVPNKEPIANYGPFVMNTPEEIEQAIQDYQSGTLTL

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Crispr_ID: NZ_CP051183_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP051183_8

2656418-2656534

Orphan

Consensus_repeat	Method
CATGGATTCCCGATCGAGTCGGGAATGAC	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP051183_8

>merge|NZ_CP051183|8|2656418-2656534|CRISPRCasFinder
CATGGATTCCCGATCGAGTCGGGAATGACGAACTTTGCTGTCATTCTCAGCTCGACTGAGAATCTATCCAGTTGATTTCATACCGATACATGGATTCCCGATCGAGTCGGGAATGAC

>NZ_CP051183|8|8|2656418-2656534|CRISPRCasFinder
CATGGATTCCCGATCGAGTCGGGAATGAC	GAACTTTGCTGTCATTCTCAGCTCGACTGAGAATCTATCCAGTTGATTTCATACCGATA
CATGGATTCCCGATCGAGTCGGGAATGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP051183.1\|WP_007019200.1\|2648603_2650820_+\|hypothetical-protein	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|176648
NZ_CP051183.1\|WP_007019190.1\|2662244_2663468_+\|saccharopine-dehydrogenase	unknown	unknown	gnl\|CDD\|225807
NZ_CP051183.1\|WP_007016094.1\|2641408_2642980_-\|IS1182-family-transposase	unknown	unknown	gnl\|CDD\|372705
NZ_CP051183.1\|WP_007017109.1\|2647211_2648228_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|226077
NZ_CP051183.1\|WP_007019191.1\|2661338_2661806_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|334464
NZ_CP051183.1\|WP_007017105.1\|2644337_2645909_-\|IS1182-family-transposase	unknown	unknown	gnl\|CDD\|372705
NZ_CP051183.1\|WP_133308539.1\|2653333_2654413_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_007019196.1\|2656616_2658533_-\|TIGR03545-family-protein	unknown	unknown	gnl\|CDD\|274640
NZ_CP051183.1\|WP_007019202.1\|2646053_2646545_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_007019199.1\|2651029_2653198_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366534
NZ_CP051183.1\|WP_007019195.1\|2658534_2659041_-\|TIGR03546-family-protein	unknown	unknown	gnl\|CDD\|200289
NZ_CP051183.1\|WP_007016093.1\|2643116_2644163_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_007019187.1\|2664934_2665603_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376162
NZ_CP051183.1\|WP_133308537.1\|2663608_2664481_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_007019193.1\|2659979_2660570_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_007019192.1\|2660639_2661299_+\|2OG-Fe(II)-oxygenase	unknown	unknown	gnl\|CDD\|379309
NZ_CP051183.1\|WP_007019197.1\|2654469_2656245_-\|SLC13-family-permease	unknown	unknown	gnl\|CDD\|238535
NZ_CP051183.1\|WP_007019188.1\|2664547_2664931_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP051183.1\|WP_007019194.1\|2659065_2659983_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223730
NZ_CP051183.1\|WP_007019201.1\|2646635_2646947_-\|DUF2695-domain-containing-protein	unknown	unknown	gnl\|CDD\|378505

Protein	Function_ID	Function_description	E-value
NZ_CP051183.1\|WP_007019200.1\|2648603_2650820_+\|hypothetical-protein	gnl\|CDD\|176648	cd06127, DEDDh, DEDDh 3'-5' exonuclease domain family. DEDDh exonucleases, part of the DnaQ-like (or DEDD) exonuclease superfamily, catalyze the excision of nucleoside monophosphates at the DNA or RNA termini in the 3'-5' direction. These proteins contain four invariant acidic residues in three conserved sequence motifs termed ExoI, ExoII and ExoIII. DEDDh exonucleases are classified as such because of the presence of specific Hx(4)D conserved pattern at the ExoIII motif. The four conserved acidic residues are clustered around the active site and serve as ligands for the two metal ions required for catalysis. Most DEDDh exonucleases are the proofreading subunits (epsilon) or domains of bacterial DNA polymerase III, the main replicating enzyme in bacteria, which functions as the chromosomal replicase. Other members include other DNA and RNA exonucleases such as RNase T, Oligoribonuclease, and RNA exonuclease (REX), among others.	1.49383e-54
NZ_CP051183.1\|WP_007019190.1\|2662244_2663468_+\|saccharopine-dehydrogenase	gnl\|CDD\|225807	COG3268, COG3268, Uncharacterized conserved protein [Function unknown].	3.348e-90
NZ_CP051183.1\|WP_007016094.1\|2641408_2642980_-\|IS1182-family-transposase	gnl\|CDD\|372705	pfam13751, DDE_Tnp_1_6, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	6.46251e-30
NZ_CP051183.1\|WP_007017109.1\|2647211_2648228_-\|IS110-family-transposase	gnl\|CDD\|226077	COG3547, COG3547, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	6.62578e-54
NZ_CP051183.1\|WP_007019191.1\|2661338_2661806_+\|hypothetical-protein	gnl\|CDD\|334464	pfam01272, GreA_GreB, Transcription elongation factor, GreA/GreB, C-term. This domain has an FKBP-like fold.	2.72355e-06
NZ_CP051183.1\|WP_007017105.1\|2644337_2645909_-\|IS1182-family-transposase	gnl\|CDD\|372705	pfam13751, DDE_Tnp_1_6, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	3.17611e-29
NZ_CP051183.1\|WP_007019196.1\|2656616_2658533_-\|TIGR03545-family-protein	gnl\|CDD\|274640	TIGR03545, TIGR03545, TIGR03545 family protein. This model represents a relatively rare but broadly distributed uncharacterized protein family, distributed in 1-2 percent of bacterial genomes, all of which have outer membranes. In many of these genomes, it is part of a two-gene pair.	3.17745e-101
NZ_CP051183.1\|WP_007019187.1\|2664934_2665603_-\|hypothetical-protein	gnl\|CDD\|376162	pfam18739, HEPN_Apea, Apea-like HEPN. Apea-like HEPN nuclease. In epsilonproteobacteria embedded in R-M operons.	0.00038844
NZ_CP051183.1\|WP_007019199.1\|2651029_2653198_+\|hypothetical-protein	gnl\|CDD\|366534	pfam01244, Peptidase_M19, Membrane dipeptidase (Peptidase family M19).	1.22431e-08
NZ_CP051183.1\|WP_007019195.1\|2658534_2659041_-\|TIGR03546-family-protein	gnl\|CDD\|200289	TIGR03546, TIGR03546, TIGR03546 family protein. Members of this family are uncharacterized proteins, usually encoded by a gene adjacent to a member of family TIGR03545, which is also uncharacterized.	9.21081e-40
NZ_CP051183.1\|WP_007019192.1\|2660639_2661299_+\|2OG-Fe(II)-oxygenase	gnl\|CDD\|379309	pfam13640, 2OG-FeII_Oxy_3, 2OG-Fe(II) oxygenase superfamily. This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily.	8.8243e-25
NZ_CP051183.1\|WP_007019197.1\|2654469_2656245_-\|SLC13-family-permease	gnl\|CDD\|238535	cd01115, SLC13_permease, Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.	2.29923e-35
NZ_CP051183.1\|WP_007019194.1\|2659065_2659983_-\|alpha/beta-hydrolase	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	4.63749e-19
NZ_CP051183.1\|WP_007019201.1\|2646635_2646947_-\|DUF2695-domain-containing-protein	gnl\|CDD\|378505	pfam10905, DUF2695, Protein of unknown function (DUF2695). This bacterial family of proteins has no known function.	1.25604e-15

>NZ_CP051183.1|WP_007019197.1|2654469_2656245_-|SLC13-family-permease
MDWQASLTLGLMVLALGVLIFTRLAPHMVMMAVMVVLSITGILDANEALAGFSNAGLVTVAAMFVVAAGIHASGGIDLLVNKALGQPKGLRGALLRIFAPVFGLSGFLNNTPVVATMIPAIHAWSRKINIPSSKLMIPLSYCAILGGTLTLIGTSTNLLVAGMYNEITGESQLSIFSITAVGLPVALMGLVFMWYFFPKWLPDRSDKSGFANLREFTLEVAVAHHGPLVGKSVQEAGLRDLSQVYLVEIERNDTVVTAVSSEEKLQGGDRLVFAGETEAISDLLRINGIEPSTDGDYSESIAIERAERRLVEVVVSPHCDALGNTIRDSKFRNRYGAVVLAVARNGERVQGNLGSIRLEAGDTLLLEARPAFVSRQRFNKDFLLVNDLDSEPPRHERAYLSWGILALVVLLAAFGVTSMLNASLLGAGLMIVSGCCSISRAEKSLDLTVIVTIGASFALGAALQKTGAGQAIAGGIIDLSFGIPWLMLILTYITVSMLTESITNNAAAVLMLPIVLEITEKASLNHEPFVFAVMMAASASFATPLGYQTNLMVYGPGNYRFTDFLKVGLPMNVFIGVMTISVLLIGWPLTQ
>NZ_CP051183.1|WP_133308539.1|2653333_2654413_+|hypothetical-protein
MKYLPVFLPLCVSFCSMSLTSHALDKQLVTYKQTQYTPIFDNDGVFPKDSIDFNSSTFTELTYSSPSEKEFSVEVSALLNADNEVDQLKALFNWGGTVIVASQGTIEGSFEQTDEARFPGNQDPDELFQTLLPNEASFEGESSFLGLGWEMYGDRIVGLGYQKTVSPVLLSIDTFQSYEFGFNNRTGEFENYHPEGTYPYKAVDAEGTIETYGLWVRLDPLSKAFEKVERTGQSESGFFFSADVMTGIAVYTPGEQVETDYAEATEAVAASVGRPGEGTTLEVAEATSLLTSRLVYGTGYQVVFPVSSAIVGASIGVEGSLHVNLFESDYASGSGAEGEIFTESSNFGYGFFFRLAVAY
>NZ_CP051183.1|WP_007019199.1|2651029_2653198_+|hypothetical-protein
MTCAAVKVSTLAFATCLSAGVLGFSSAPEPQSQPQAPGYNGDAHSIAQQCYAIQSPENGNYLQKFNNGSPVDNGLSYRFANISKDSATRFFVKPTGLGRFMLTDRDGRYFATHLPGQIGAGRYAGKFAEWTIEKQGSERFSFHGTGLNMKLRHNYNDGGLYFFDLLNPFNFNSEDSFKLVAQTNCKPYPEVTTNVTGDVNNLKGNVNQPIRGYVDPHTHITSYEFMGGKMMAGKPFHRWGVEEALKDSKDIHGPNGSLDLIGNLYTFEDPNMRYDTRGWPDFPWWPNHKQMSHSGYYYKWIERAYLSGLRLMVTDLVENEVLCNVQKTINPASWINPNSCNTMDSIRLQAKRLHEMQDYIDAQSGGPGEGFFRLVTSPEQARQVIADGKMAVLMGVEASETFNCGLKDSCSKDSIEAQLNELYDMGIRTIYPTHKFDNQLAGSAVEDGFINLGQWLSGGRFFETKECDDHTKGRYFKSGFPLIGDVPVIRDILNGVGLNPVYDESIQHCNEHGITELGVYLVNRMIDKKMLVELDHMSNDTATAVMDIVEARNYSGVITSHSWMRDGKNGEVHSNTERLIRSGGFSAPYNSDAHNVVGSISRYLDVVEDTPYLNGVGFGTDMSGLGGQAGPRYDTDINPLEYPFTTEFGLTFEQQKSGNRVFDLNTDGIAHYGMVADHVQDIREQAPQRIYESVMNSAEAYIQMWERAEASPDTPHYDPLAD
>NZ_CP051183.1|WP_007019200.1|2648603_2650820_+|hypothetical-protein
MKELPEKYYLTHFCEFLSYLSDTCRHLLDEGDWAHLNAFKALPEEAQCVFVRMLNRKGDVIKTGDFRYAEVSDIPSALADLEHAGFIQGVTEPFFNDWLLALNKEELIALAHYRLEHHEHSSALNDFDTQPLPKKSHTKSRWLSWVQHHVSPCSLMNAPFALMQQYHVIAKADVVQYWLFLYFGHLRGRLNQFSLRDMGIMHTHQEQHINGARFDDLDQAKSAFFFSLQNQNLKLTSDDDLADFARKAKAFNEADGQQAESHRDKLFYRLGKRLLSLPLSDTFSATDRDHLAMSVLELSHDPAAIEKSIRLLYQKGEHDEVQTRLQDIIDDPSSEHLLIFAQDFLQRKFHKKRTSLLTDLLRACESPISLDEAYRGYAEGGVIDHYQRSGVRAFHSENNIWRALFTLFFWHELYEHEASGFHSEFDFKPKLIKQRQFYAVLSSAIESRLQSIRSKTDLLKCIQSNWARHYGQRNGLFHWHASLLEPLTLLIQYGSLPGLIEHLRNMAKQFHELCDGYPDLMIIDDNGIRFEEIKAPGDQLRRNQLISLQSLKRNGFDVRVQTTDWKINPEQPYVIVDVETTGGRKEQHRVTEVGMVKVLNGEIVDEWQSLINPMRHIPQSITRLTGISNEMVSNAPVFDDVADEIAEFCAGSVFVAHNVNFDYGFFRSEFERLGRRFHAPKLCTVQMSRKYLPGHSSYSLGKLCAALDIDLENHHRALDDAKAAAHVFRLIQEKRQTS
>NZ_CP051183.1|WP_007017109.1|2647211_2648228_-|IS110-family-transposase
MNQIHAIGIDLAKSVFQVCAFDEYGKKLLNKALRRNQVLKFLANIEPCLVGMEACGSAHYWAREIKKLGHKVRLMPPQYVKPYVKTNKNDSADAEAICEAVSRPTMRFVTVKSEEQQALLLLHRERDGVVRDRTSLINRIRASLHEFGISIPAGRFRLRKWFREDFGVLESKIPSMLLNHIKLMHTRLVDIEAYLEELDRQIDSASRKSEQCKKVQEIPGVGRLTSSALVASIGDAKEFKSGRQLSAWLGLVPSQHSSGGKALLLGISKRGDAYLRRMFIHGARAVIRHTKEGKPFHEWIMALLKRMHKNKVIVALANKLVRIAWAILAKQSQYCATI
>NZ_CP051183.1|WP_007019201.1|2646635_2646947_-|DUF2695-domain-containing-protein
MDKEQKKKLKAQFKQNEQDEIRASIPMSIDDLKDLLSYLNRDSAPECDHSLKESIEFIKSRKLDPEVVIPWLGEHGGFCDCEVIYNVYDDVGDIVGWHLDENS
>NZ_CP051183.1|WP_007019202.1|2646053_2646545_-|hypothetical-protein
MHLEKLEEWLRSLRQEDDLLVGEIRVPFLSQEDPIEVCFVGQQSAVTDNQLNTMRGYLERVEDYHAKAVERIFNEYQATIEISREAFREWKENPDVSAPRIDKPDELASLLVYQSMFIPAWREVGTFGMGFWAKWEVEHGVGLRFEDWQISEAGENAVHFQFG
>NZ_CP051183.1|WP_007017105.1|2644337_2645909_-|IS1182-family-transposase
MPKFIPYNYDQTSMVVINFKDQLQSGTFEYAVHYLINEKLDLSIFYPNYNNSSSGRPAYDPAILLKIILFAYSKGITSSREIQWCCETNIIFKALSCDTVPHFTTIASFVSGHSSEIENLFEQILLICHEQGLLGNELFAIDGCKMSSNAAKEWSGTFKELEEKRAKIKRLIKHHITEHKKIDKNESLGEERAKCAQQAIKTLSDAYDKIDKFLKTSSPRMGQGKRKQEVKSNITDNQSGKMTTSKGTIQGYNGVATVDKKHQIIIDAQAFGEGQEHHTLRPIIEKVRERYKRIGISKDIYKKKTIVTADTGFANEANMKYLYESGINAYVPDNQFRSRDPKFARQKRKYGKRHQNEKKKSHVRNVIPPSEFHFDPVNLICVCPAGETLSYQNTRTSESGAPKAFFNGRIMQCRNCELKTKCMQNPASADHRKGSGRQVSFTLSHKRGPTYTDWMKHRVDSQEGKQIYSHRMSVVEPVFANIGTNKGLNRFSLRGKAKVESQWQLYCMVHNIEKLTNYGQLSH
>NZ_CP051183.1|WP_007016093.1|2643116_2644163_-|hypothetical-protein
MQILELLELTFWIDRNIKSPAITQKYQQLQAVIQQNVNARNNQAKQPFEVQKNAVIDEIIDISTSSLTNEQERMLSSFGILDHLGQTGVDKLEGILFKNSLDIATAAVKVNEIVQKFNIAIQRSDQIQTNLKPLIPDYESQEEPENNENVVMRVHFQNEVSLENISDFKKLGNTWWEIGRGIAMAHDHSPEDIKVIGAQKGSIIIELAVIAAIATTTSTIILSALKVADRVLTIRKKAEEIKALKLSNQKLENDLEKEAEKEKKEGLENITKEISINLNINQNGDGEKVKVLEKSIRNLIDFVEKGGEVDFFTPDQDEESEEIEKLRVNFSEIKKLEKRVLSLEDKNS
>NZ_CP051183.1|WP_007016094.1|2641408_2642980_-|IS1182-family-transposase
MPKFIPYNYDQTSMVVINFKDQLQPGTFEYAVHYLINEKLDLSIFYPKYSNHDSGRPAYDPAILLKIILFAYSKGITSSREIQWCCETNIIFKALSCDTVPHFTTIAAFVSGHTSEIEHLFEQILLICHEQGLLGNELFAIDGCKMSSNAAKEWSGTFKELEEKRSKIKRLINHHVTEHKAIDKYDSLNEERTKRAEKAIETLSKAHEKINEFLKTSDPRMGQGKRKQEVKSNITDNQSAKMTTSKGTIQGYNGVATVDKKHQIIIDAQAFGEGQEHHTLRPILEKVQDRYKRIGISNNIYKKKTIVTADTGFANEANMKYLHESGINAYVPDNHFRSRDPKFAEQKKKYGKRHQNEKKKGSVRNVIPPSEFNFDPVNLVCVCPAGETLSYQNTRISDSGAPKAFFNGRIMQCRNCELKTKCMQNPASADHRKGSGRQVSFTLSHKRGPTYTDWMKHRVDSKEGKQIYSHRMSVVEPVFANIGTNKGLNRFSLRGKDKVESQWQLYCMVHNIEKLTNYGQLSH
>NZ_CP051183.1|WP_007019196.1|2656616_2658533_-|TIGR03545-family-protein
MLKWIRWSGIAGFLVVMALIASFWLFAAGPLVKMTIEYFGSRTAEAEVNVEDVSFAFNPLAIEITGVQVADKDAPMTNLFSFDKAVATIEPLPLLVGKAVIPELVLDGVATGTERSRSGALIEKSTESQQQAKTSQESDDNTEDKAFTYDPTTKDKLPSVDEIVTRENLLTEQRGKALEQAVKDHEMAINQAEDNLPTEDSLKDYEQRLDQILSGRFKSVEDFKQRKRQFEDLKQQFKQDKQAIRNAKQTIETAKSDLKQKWSALKRAPKEDINNIKNKYTLDAQGTANLTALLFGDDMGGYAATALKYYEMARPYLVNEELKATKTEAKAARLEGRFVHFETDRPVPDFWIKQTRFSVKLPEATDKSGQLRSMGNVKVRIQDITHQPDVINKPMTLLATGTDLTTMDALTLKGRFDHRRAVNDGRGEDKLNLTIENWRLYEMKLGLAGLSIEETNTQVSANAVLVGRDLNAQGVMTFSKSAFSSSDRTVLAKEMLAALRTIDQFNLEASAKGEFNDPDLRIASDLDRQLENAFDERIDQKQAEFEQKLKDKLNEKLLSYSGDYQAQLKDLNLAEGRLSDKQEALENLAKAEISSYQDQLKAEAKAKAEKEKAKAKAEADRKKKELEEKAKKALKDLF
>NZ_CP051183.1|WP_007019195.1|2658534_2659041_-|TIGR03546-family-protein
MLTMLAKFLKILGSDASPLQIAFGFALALFIGLTPFFSLHNLVILFIAFVTRVNLGAFFLASAIFTLIAYLIDPWSISLGEYLLTLPDLQTVWTSLYQSDFWRAFKFNHTLLMGSLAISVIAFIPVLILSYVFVVFYRHKFMAWVEKLKITKWLKASKFYKVYEEMGA
>NZ_CP051183.1|WP_007019194.1|2659065_2659983_-|alpha/beta-hydrolase
MIWAVLIALWVLLVVVILFKPLWLMNYLLSPVGATFAGVKRIKNLQYGQDARQSMDVYLPIEYSADTPWVMFVHGGAWDTGHKDEYAFAGRALAELGFACAVPTYRLYPAVKYPHFIEDIAEAVRRLPSLIDAKSIDSQGLRQNGFVMMGHSAGAHTGAMLATHEQYLQESDTSINQFIGLAGPYDLPLDDPLVVGKFDGVRVYDVSEIREDYGHEHNAHEANPINWAHENMPPCLLIHGSDDVTVGPYHSERFSRRLEQLHVKHDCIMIEEVNHRHLVGALCYGLRWLNPVYTMISDTLRTTKH
>NZ_CP051183.1|WP_007019193.1|2659979_2660570_-|hypothetical-protein
MSISNSYPWQGLGDHILHYEDAQPLPITVYTANRPPIQPFEHPNGVVPLADADISYIAQMTGNHWRKIFNVYAKLMHSAFPFYDKWQTYREHCLLQARSGTRLLFGCHDMSNQFQWDAGLHLIMGKQHAEDCGLQYENSHDFTPLSTRIFQHRQRPLWVCPYFDYRQLNNEQIEILAHAMRQYCQRMGYLKKGNIL
>NZ_CP051183.1|WP_007019192.1|2660639_2661299_+|2OG-Fe(II)-oxygenase
MDLTQERDPSVSEIYQKICDDIYAQGYSIIDNALPQALLQSLMNHIATLSSQEFKVAGTGRQDEHQVNQFVRRDEIHWLSEERECEREWFHWAQGLQTEINKRLMLGLFSYEAHMAHYEPGAFYKKHLDAFKGSRSRVLSTVLYLNPQWQSNYGGELVIYDEHNHDSELTRVSPMPGTLVVFLSEDFPHEVLPAREHRHSIAGWFRVNESVGNQIAPPQ
>NZ_CP051183.1|WP_007019191.1|2661338_2661806_+|hypothetical-protein
MDKHTLLDQLVQQLLADIDEHIKAAEQAHNAATHEQSKAETQYDTLGLEQAYLAHGQSERIDNLQQQIARLNHFDLRTFDEDDEIHLGAFVQLINSQTNKNLDVFILPCAGGYTLEKSIHTLTPDTPIAKAIMGLGIDDEFKLGNGQRYRITKVS
>NZ_CP051183.1|WP_007019190.1|2662244_2663468_+|saccharopine-dehydrogenase
MADSQYDIIIFGATSFVGDILTGYMHKTYGTNGEIKWAMAGRSESKLQAIKSKHGAQDVPHFIADASNEEQLKTLADKARVIVSTVGPYALYGEPLVKVCVESGTDYCDLTGEVQWYKRMVDKYEAKAKETGARIVHCSGFDSIPSDLGVYFTQQQAQKTFGEMCHQIDMRVAKLKGGASGGTVASMMNIAKEAAKDPKLRKELQNPYSICPSDHGFKTRQHNVGGAEFDENVDGWIGPFVMAAVNTRVVHRSNVLQDKAYGQDFKYSEAMMMGKGKKGEKRAKSMGRMLKWFMIFAAIAPTRWLLEKFVPKPGEGPSPKEQEEGMFDMRFYGQTPSGKKIIAKVVGDRDPGYGSTAKMLGQAAVCLANINKDEKAGGFWTPASIYQDDLIERLQAKSGLTFEVLGS
>NZ_CP051183.1|WP_133308537.1|2663608_2664481_+|hypothetical-protein
MRFYPLIILALSIVIIPSWADDKSDLVPRPMAMGIQYSQLDSAQLADSDLHLAIHRSRLKLPINRYALLGHTFIPHLSYEESVFQVPNPASASSLTLHTIKTPLMFIKKQDNGWLRILNITPSWHTDLKAKDEKSYSLMGLLLWRFRDESSPHSYTFGLGMNRLFGEYKPVPMVAYSYQTSTHTRYDFGFPVTKAEHRFNNSWAAFSAIAPSGGNWRYQTRNEEQRLNLSYKGWNATLGLRRHLWKKVWLTLEVGKSIDRSLDFSNDSIDSQEVKIEDTTIYKISIGLHP
>NZ_CP051183.1|WP_007019188.1|2664547_2664931_+|hypothetical-protein
MSDSVLHQRIEDALKAIIPFAQQADEIIEALKAENKAKFTAIFPQDSIFQTTANRFLPYIEELDKDYQALPEDVNDPAFEPLLKDLVKKMELIQLILQEFHNARDYDDEEESSPTIEPDSDEKPTLH
>NZ_CP051183.1|WP_007019187.1|2664934_2665603_-|hypothetical-protein
MEYADLNFETLKSSLKEKRGELSETHATRLHRAISWLKCAEEQSENPDLQLISLWIAFNACYAVDEGGSESLAEQFAFQRFVSKLVRHDQSQAIYACLWQTYSGPVKALIKNPYVYHGFWLAKRRDIEDESWSEQFDRSSVEALNFLSRQNVEGLLGIVLDRLFVLRNQVIHGGATYQSQINRTQVSDGVKLLGALVPTVLEIMLDTPEEDWGDIYYPVINQ

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1857697 : 1865800

uncultured_Caudovirales_phage(71.43%)

tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_168367061.1\|1857697_1858792_-	agmatine deiminase family protein	A7IVE6	Paramecium_bursaria_Chlorella_virus	1.0e-48	34.7
WP_007016884.1\|1859224_1859905_+	Bax inhibitor-1/YccA family protein	A0A2H4JFM9	uncultured_Caudovirales_phage	1.1e-35	44.6
WP_007016885.1\|1860001_1860391_+	sulfurtransferase complex subunit TusD	A0A2H4JA39	uncultured_Caudovirales_phage	8.2e-25	46.1
WP_007016886.1\|1860387_1860747_+	sulfurtransferase complex subunit TusC	A0A2H4J8C0	uncultured_Caudovirales_phage	8.1e-11	32.2
WP_007016887.1\|1860749_1861034_+	sulfurtransferase complex subunit TusB	NA	NA	NA	NA
WP_007016888.1\|1861037_1861352_+	TusE/DsrC/DsvC family sulfur relay protein	A0A2H4J8B6	uncultured_Caudovirales_phage	2.5e-24	52.6
WP_007016889.1\|1861365_1862361_+	glycosyl transferase family protein	A0A2H4JBY5	uncultured_Caudovirales_phage	1.6e-85	48.9
WP_007016890.1\|1862376_1862532_-	hypothetical protein	NA	NA	NA	NA
WP_007016891.1\|1862599_1862833_-	sulfurtransferase TusA	NA	NA	NA	NA
WP_007016892.1\|1862822_1863317_-	hypothetical protein	NA	NA	NA	NA
WP_007016893.1\|1863434_1865189_+\|tRNA	proline--tRNA ligase	NA	NA	NA	NA
WP_007016894.1\|1865200_1865800_+	lytic transglycosylase domain-containing protein	A0A0H3V0Q1	Geobacillus_virus	3.3e-09	39.8

DBSCAN-SWA_2

2063169 : 2075663

Shigella_phage(33.33%)

integrase,transposase

attL 2067457:2067470|attR 2077100:2077113

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_083771882.1\|2063169_2064057_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	2.0e-34	32.5
WP_007017095.1\|2064008_2064368_-\|transposase	transposase	NA	NA	NA	NA
WP_007017096.1\|2064464_2064773_-	hypothetical protein	NA	NA	NA	NA
WP_007017097.1\|2064914_2065127_-	hypothetical protein	NA	NA	NA	NA
WP_007017098.1\|2065248_2066337_-	hypothetical protein	NA	NA	NA	NA
WP_007017099.1\|2066563_2067124_-	hypothetical protein	NA	NA	NA	NA
WP_133308422.1\|2067120_2068313_-\|transposase	IS3 family transposase	A0A1P8CWQ3	Bacillus_phage	5.8e-37	34.3
2067457:2067470	attL	NA	NA	NA	NA
WP_007017102.1\|2068414_2068819_-	hypothetical protein	NA	NA	NA	NA
WP_007017103.1\|2068891_2069329_-	hypothetical protein	NA	NA	NA	NA
WP_007017104.1\|2069451_2069742_-	hypothetical protein	NA	NA	NA	NA
WP_007017105.1\|2069907_2071479_-\|transposase	IS1182 family transposase	NA	NA	NA	NA
WP_007017106.1\|2071640_2071895_-	hypothetical protein	NA	NA	NA	NA
WP_007017107.1\|2071981_2072368_-	tautomerase family protein	NA	NA	NA	NA
WP_007017108.1\|2072489_2073044_-	hypothetical protein	NA	NA	NA	NA
WP_007017109.1\|2073311_2074328_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_007017110.1\|2074703_2075663_+\|integrase	integron integrase	A0A1P8DJJ6	Virus_Rctr41k	2.4e-57	41.5
2077100:2077113	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP051184

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP051183

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CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection