CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP053109	Streptomyces sp. Z423-1 chromosome	15 crisprs	csa3,DEDDh,DinG,cas3,RT,c2c9_V-U4,WYL,Cas9_archaeal,Cas14u_CAS-V,cas4	1	12	11	1

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP053109_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053109_1

1534061-1534236

Orphan

Consensus_repeat	Method
AGGGGGCTTCAGCCGACCGGCC	CRT

3 spacers

The CRISPR arrays of NZ_CP053109_1

>merge|NZ_CP053109|1|1534061-1534236|CRT
GGGGGGCTTCGGCCGACCGGCACCTGAGGGGCCTCAGCTGAGAGGCCTCAGGTGAGGGGGCTTCAGCCGACCGACCGGGCCTGAGGGCTTTCAGCTGAGAGGGCTCCAGCCGACCGGCCGCATCTGAGGGACCTTGACTGAGGGGCCTCGGCCAAAGCGGCTTCAGCCGACCGGCC

>NZ_CP053109|1|1|1534061-1534236|CRT
GGGGGGCTTCGGCCGACCGGCA	CCTGAGGGGCCTCAGCTGAGAGGCCTCAGGTG
AGGGGGCTTCAGCCGACCGACC	GGGCCTGAGGGCTTTCAGCTG
AGAGGGCTCCAGCCGACCGGCC	GCATCTGAGGGACCTTGACTGAGGGGCCTCGGCCA
AAGCGGCTTCAGCCGACCGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053109.1\|WP_171116826.1\|1522564_1523833_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP053109.1\|WP_171116860.1\|1541658_1544166_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP053109.1\|WP_171116850.1\|1537528_1538440_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270694
NZ_CP053109.1\|WP_171116838.1\|1530455_1531580_-\|allantoicase	unknown	unknown	gnl\|CDD\|237319
NZ_CP053109.1\|WP_171116830.1\|1525594_1527664_+\|RICIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|373145
NZ_CP053109.1\|WP_171116839.1\|1531612_1532947_-\|allantoinase-AllB	unknown	unknown	gnl\|CDD\|163175
NZ_CP053109.1\|WP_171116828.1\|1524004_1524205_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171116852.1\|1538505_1539579_-\|NAD(+)/NADH-kinase	unknown	unknown	gnl\|CDD\|223139
NZ_CP053109.1\|WP_171119052.1\|1534251_1534566_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171116846.1\|1535557_1537183_+\|malate-synthase-A	unknown	unknown	gnl\|CDD\|236432
NZ_CP053109.1\|WP_171116843.1\|1534761_1535364_+\|nucleotidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|133025
NZ_CP053109.1\|WP_171116854.1\|1539725_1540376_-\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224103
NZ_CP053109.1\|WP_171116841.1\|1533231_1534026_+\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_CP053109.1\|WP_171116858.1\|1541186_1541627_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171116836.1\|1529608_1530376_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235500
NZ_CP053109.1\|WP_171119050.1\|1524327_1525326_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380488
NZ_CP053109.1\|WP_171116856.1\|1540499_1540871_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP053109.1\|WP_171116848.1\|1537199_1537475_-\|SelT/SelW/SelH-family-protein	unknown	unknown	gnl\|CDD\|378415
NZ_CP053109.1\|WP_171116834.1\|1528683_1529508_-\|AIM24-family-protein	unknown	unknown	gnl\|CDD\|376704
NZ_CP053109.1\|WP_171116832.1\|1527958_1528585_-\|dihydrofolate-reductase-family-protein	unknown	unknown	gnl\|CDD\|334719

Protein	Function_ID	Function_description	E-value
NZ_CP053109.1\|WP_171116826.1\|1522564_1523833_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	3.32301e-35
NZ_CP053109.1\|WP_171116860.1\|1541658_1544166_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.53887e-31
NZ_CP053109.1\|WP_171116850.1\|1537528_1538440_-\|hypothetical-protein	gnl\|CDD\|270694	cd05124, AFK, Catalytic domain of Actin-Fragmin Kinase. AFK is found in slime molds, ciliates, and flowering plants. It catalyzes the transfer of the gamma-phosphoryl group from ATP specifically to threonine residues in the actin-fragmin complex. The phosphorylation sites are located at a minor contact site for DNase I and at an actin-actin contact site. Fragmin is an actin-binding protein that functions as a regulator of the microfilament system. It interferes with the growth of F-actin by severing actin filaments and capping their ends. The phosphorylation of the actin-fragmin complex inhibits its nucleation activity and results in calcium-dependent capping activity. Thus, AFK plays a role in regulating actin polymerization. The AFK catalytic domain is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.21179e-07
NZ_CP053109.1\|WP_171116838.1\|1530455_1531580_-\|allantoicase	gnl\|CDD\|237319	PRK13257, PRK13257, allantoicase; Provisional.	0
NZ_CP053109.1\|WP_171116830.1\|1525594_1527664_+\|RICIN-domain-containing-protein	gnl\|CDD\|373145	pfam14587, Glyco_hydr_30_2, O-Glycosyl hydrolase family 30.	1.62376e-17
NZ_CP053109.1\|WP_171116839.1\|1531612_1532947_-\|allantoinase-AllB	gnl\|CDD\|163175	TIGR03178, allantoinase, allantoinase. This enzyme carries out the first step in the degradation of allantoin, a ring-opening hydrolysis. The seed members of this model are all in the vicinity of other genes involved in the processes of xanthine/urate/allantoin catabolism. Although not included in the seed, many eukaryotic homologs of this family are included above the trusted cutoff. Below the noise cutoff are related hydantoinases.	0
NZ_CP053109.1\|WP_171116854.1\|1539725_1540376_-\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|224103	COG1182, AcpD, Acyl carrier protein phosphodiesterase [Lipid metabolism].	8.02859e-44
NZ_CP053109.1\|WP_171116852.1\|1538505_1539579_-\|NAD(+)/NADH-kinase	gnl\|CDD\|223139	COG0061, nadF, NAD kinase [Coenzyme metabolism].	5.8056e-55
NZ_CP053109.1\|WP_171116846.1\|1535557_1537183_+\|malate-synthase-A	gnl\|CDD\|236432	PRK09255, PRK09255, malate synthase; Validated.	0
NZ_CP053109.1\|WP_171116843.1\|1534761_1535364_+\|nucleotidyltransferase-family-protein	gnl\|CDD\|133025	cd04182, GT_2_like_f, GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	1.26268e-56
NZ_CP053109.1\|WP_171116841.1\|1533231_1534026_+\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	2.3284e-72
NZ_CP053109.1\|WP_171116836.1\|1529608_1530376_+\|SDR-family-oxidoreductase	gnl\|CDD\|235500	PRK05557, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Validated.	2.77922e-85
NZ_CP053109.1\|WP_171119050.1\|1524327_1525326_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380488	cd01574, PBP1_LacI, ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators. Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators. The ligand-binding domain of LacI is structurally homologous to the periplasmic sugar-binding domain of ABC-type transporters and both domains contain the type 1 periplasmic binding protein-like fold. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the type 1 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	5.27373e-110
NZ_CP053109.1\|WP_171116856.1\|1540499_1540871_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	1.76503e-32
NZ_CP053109.1\|WP_171116848.1\|1537199_1537475_-\|SelT/SelW/SelH-family-protein	gnl\|CDD\|378415	pfam10262, Rdx, Rdx family. This entry is an approximately 100 residue region of selenoprotein-T, conserved from plants to humans. The protein binds to UDP-glucose:glycoprotein glucosyltransferase (UGTR), the endoplasmic reticulum (ER)-resident protein, which is known to be involved in the quality control of protein folding. Selenium (Se) plays an essential role in cell survival and most of the effects of Se are probably mediated by selenoproteins, including selenoprotein T. However, despite its binding to UGTR and that its mRNA is up-regulated in extended asphyxia, the function of the protein and hence of this region of it is unknown. Selenoprotein W contains selenium as selenocysteine in the primary protein structure and levels of this selenoprotein are affected by selenium.	3.08756e-37
NZ_CP053109.1\|WP_171116834.1\|1528683_1529508_-\|AIM24-family-protein	gnl\|CDD\|376704	pfam01987, AIM24, Mitochondrial biogenesis AIM24. In eukaryotes, this domain is involved in mitochondrial biogenesis. Its function in prokaryotes in unknown.	7.22715e-58
NZ_CP053109.1\|WP_171116832.1\|1527958_1528585_-\|dihydrofolate-reductase-family-protein	gnl\|CDD\|334719	pfam01872, RibD_C, RibD C-terminal domain. The function of this domain is not known, but it is thought to be involved in riboflavin biosynthesis. This domain is found in the C-terminus of RibD/RibG, in combination with pfam00383, as well as in isolation in some archaebacterial proteins. This family appears to be related to pfam00186.	5.29237e-19

>NZ_CP053109.1|WP_171116841.1|1533231_1534026_+|IclR-family-transcriptional-regulator
MPTSSASTTDSAKSANGGGVQSLERAFDLLERMADAGGEVGLSELSATSGLPLPTIHRLMRTLVACGYVRQQPNRRYALGPRLIRLGESASRLLGTWARPYLARLVEETGETANMALLDGDEIVYVAQVPSKHSMRMFTEVGRRVLPHSTGVGKALLAGFPDEEVRSLLARTGMPAATEKTITTPEGFLAALDDVRRLGYALDDNEQEIGVRCLAVSVPDSPTAAAISISGPAGRVTEAATDRIVPVLQQVATELSEALASSGA
>NZ_CP053109.1|WP_171116839.1|1531612_1532947_-|allantoinase-AllB
MSDAELVLRSTRVITPEGTRPASVAVADGKITAVLPYDAPVEAVRVEDVGDDVLLPGLVDTHVHVNDPGRTEWEGFWTATRAAAAGGITTLVDMPLNSLPPTTTVDHLRTKQEVARAKAHIDVGFWGGALPDNGKDLRPLHDAGVFGFKAFLSPSGVDEFPHLDQEQLAGSMAEIASFGGLLIVHAEDPHHLAAAPQQGGPKYAHFLASRPRDAEDTAIAHLIAQAKRLHARVHVLHLSSSDALPLIAAARAEGVRVTVETCPHYLTLTAEEVPDGASEFKCCPPIREAANQDLLWQALADGTIDCVVTDHSPSTADLKTNDFATAWGGISGLQLSLPAVWTEARKRGHTLEDVVRWMSTRTAELVGLAQKGAIEAGRDADFAVLAPDETFTVDPAALQHRNRVTAYAGRTLSGVVKSTWLRGQRIVADGEFTDPKGRLLTRTP
>NZ_CP053109.1|WP_171116838.1|1530455_1531580_-|allantoicase
MTAIPSFTGDASPYGGGDPYADYRTADFPFTQYANLADRRLGAGVIAANDEFFAQRENLLVPERAEFDPEHFGHKGKIMDGWETRRRRGASAEHPWPTAEDHDWALVRLGAPGVIRGIVVDTAHFRGNYPQSVSIEGASVPGSPSPEELLADDVKWTTLVPRTPVGGHAANGFAVAAEQRFTHLRVNQHPDGGIARLRVYGEVVPDPEWLSVLGTFDVVALENGGQVEDASNLFYSPATNTIQPGRSRKMDDGWETRRRRDQGHDWIRYRLVAQSQIRAIEIDTAYLKGNSAGWASVSVRDGEDGENGEWTEVLPRTRLQPDTNHRFVLPTPAVGTHARVDIFPDGGISRLRLFGSLTEEGATRLAARHQELGG
>NZ_CP053109.1|WP_171116836.1|1529608_1530376_+|SDR-family-oxidoreductase
MTSQATHNPTSRTILQGKVALVTGGSRGIGAATAVRLAREGADVALTYVNGKEAAQDVVRAVEALGRRAVALWADSADAAEAAGAVERAAEALGGLDVLVNNAGVGVLGPLESLSLADVDRVLAVNVRGVFLASQAAAARMTEGGRIITIGSCMTQRVPGPGGTLYATSKAALIGLTKALARELGGRGITANIVHPGPIDTDMNPADGPYAAGQAALTALGRFGTAEEVASMVAHLAGTSYVTGAEFSIDGGHAA
>NZ_CP053109.1|WP_171116834.1|1528683_1529508_-|AIM24-family-protein
MTLRQEIVGNAMQMAVVTLRPGQTVYCEAGKFLFKTANVTMETRLTGPSAGGAAQGGASGAAAAGMGGLLRQAMGTAMQVGQRALAGESLAFQYFTAQGGEGTVGFAGVLPGEMRALELDGTRAWFAEKDAFVAAESTVEFGIAFQGGRTGMKGGEGFILEKFTGHGTVVIAGAGNFIDLNPADFGGRIEVDTGCVVAFEEGIEYGVQRVGGLNRQGLMNAVFGGEGLSLATLEGNGSVILQSMTIEGLANALKKAQGGDKQGPTGGLFSTHAG
>NZ_CP053109.1|WP_171116832.1|1527958_1528585_-|dihydrofolate-reductase-family-protein
MGKLVLNSFVTLDGVYQAPGGPQEDTRDGFEQGGWVFPYADDDFGQFIDDVFQHVGAFLLGRRTYEIFAAYWPKVTDPDNLIASRLNSMPKYVASASLTDPEWSGTTVISGDLAKEVTALKENTEGELQVHGSGALAQSLLNLGLVDTVHLLTFPVVLGAGRRLFTEGIVPTAFRHTGGRITSTGVSIQTYDLAGRPEYGSFDLPENA
>NZ_CP053109.1|WP_171116830.1|1525594_1527664_+|RICIN-domain-containing-protein
MAHRTRKRRLLGTIGITALATGTVLATTSLPAAHAETTAAAASVTVRPDPSYQQQRFEGWGTSLVWFANATGDYPPEIREKLAQLLFGDDGLALNIARYNIGGGNAPDVKDYLRPGGAVEGWWKAPAGTTREDVDWWDADDPADWNKNADATQRWWVDRIKKDITHWEAFSNSPPWFMTVSGYVSGGFDSSKDQLKTESVEDFAEYLVGATERLEKAHGIKVDTLDPFNEPNTPYWGTRLGEDGEPVGGRQEGAHMGPELQQQVLRALAPALEKSRTDADISAMDETNPGTFATNWNSYPQEVRDLVGQMNVHTYGTGQRTTVRDLAKAADKPLWMSEVEGDWGDGQSFTDMRPGLGLAQRIVDDLRELEPRAWVFWQPVEDYDNMKPGGESAKGGNWGEIQIPFNCTSKDTLETCPIRTNTKFDTARNFTHYIKPGDRLIKTNDTSSTAALSKKGDAATVVHVNSTTEARDVTLDLSKFGRVSSRATVTPVVTSADGKLARQKPVRVTGKQATVTVPAQSVTSFLVKGVSGVAKDAAELKKGHTYRLTGVQSGKDLTIADNGTGLVIKSADAADPSGQHWRLEQISGTDNRKRYVFTEAAEGKRLAVRDGALVAEPDEGRRDRAAQWIMSTTGDGTWTLVNAATGQLPDVFGQSTSDGATVGVWWPNSGSNQRWKVTDVTGDAGARTE
>NZ_CP053109.1|WP_171119050.1|1524327_1525326_-|LacI-family-DNA-binding-transcriptional-regulator
MADVARLAGVSSQTVSRVSNGFPGVTEETRRQVLAAMRELGYRPNSAARALRRGEFRTLGVITFSLSTMGNIRTLEAIATSAAQHGYAVTLLPVAVPTQDEVNGAFSRLGELAVDAVIVIMEIHLLDAATVSLPPGVQVVVADSDAGDRYTVVDTDQAGGARDAVRHLLDLGHDTVWHLAGPEDSFAAQRRANAWRGTLTEAGRVPPPLVRGDWSAESGYRAGLRLADRPDCTAVFAANDQMALGLLRALHERGRRVPDDVSVVGFDDISEAASFLPPLTTIHQDFAEVGRLCVEKVLSKMRQAGPHGTEHGTTLVPTRLVLRHSTAPPPAR
>NZ_CP053109.1|WP_171116828.1|1524004_1524205_+|hypothetical-protein
MKQLLEFLGLIALVQGVMGLVHEFTDWHIGLVQRVGFLDGYEIYASVALVVLAFALFAAAESRRPG
>NZ_CP053109.1|WP_171116826.1|1522564_1523833_-|sensor-histidine-kinase
MSTVKSDRTAQTASAFEGRRWLFPSALIHALDPDAGRPGRRPRRTARDWLVDFCCFFVAIFVGLLAADSITPENTPRALLVVDQWLGALSCAAVWLRRRWPVGLAIAMIPVGFISNTAGGVGLVALFTLAVHRPFRYVAWIGGISTALIPLFFWLRPEPDLPYPVAVAFTVLLGVCVIGWGMLVRSKRQLVFSLRDRAQRAETEAHLRAEQAQRLAREAIAREMHDVLAHRLTLLSVHAGALEFRPDAPREEVARAAGVIRESAHEALQDLREIIGVLRAGEPDDAGRPQPTLAALDALVAESREAGTKVTLDLRVTDPAAVPASIGRTAYRIAQEGLTNARKHAPGTEVTVSVTGAPGEGLTISVHNPAPDGDVPHVPGSGQGLIGLTERATLAGGRLEHGARPDGGFEVRAWLPWGTPGP
>NZ_CP053109.1|WP_171119052.1|1534251_1534566_-|hypothetical-protein
MLRSLGQRPVTGSDEDPRVAELRTAVSRLRRELAAHPVEFPDRAVAEDELAALAAMTADGTPEVPRLRRSLLLIAGAIGSVSALSRGLSEVRYAVELFGEPPRS
>NZ_CP053109.1|WP_171116843.1|1534761_1535364_+|nucleotidyltransferase-family-protein
MTDQNERPVAALLLAAGGGRRLGGRPKALLEHRGRPLIEHAVAVLRAGGCARVHVVLGARADVVRERAELSGCVLVENPEWEQGMGSSLRAGLNSFAGTGARAALVSLVDQPGIGPEAVARVLAAYTDESSLVSAAYDGVRGHPVLFGAAHWADIAATATGDRGARAYLNEHASGIRLVECGDVARPYDIDTAADLKHLE
>NZ_CP053109.1|WP_171116846.1|1535557_1537183_+|malate-synthase-A
MSAPAPSPLAIVDAEPLPRQEEVLTDAALAFVAELHRRFTPRRDELLARRAERRAEIARTSALDFLPETAQIREDPTWRVAPAPAALNDRRVEITGPTDRKMTINALNSGAKVWLADFEDASAPTWENVLLGQLNLIDAYTRNIDFTDPGSGKSYALKADEELATVVMRPRGWHLNERHLVDANGTQVPGALVDFGLYFFHNAQRLLDLGKGPYFYLPKTESHLEARLWNEVFVFAQDYVGIPQGTIRATVLIETITAAYEMEEILYELRDHASGLNAGRWDYLFSIVKNFRDGGPKFVLPDRNAVTMTAPFMRAYTELLVRTCHKRGAHAIGGMAAFIPSRKDPEVNKVAFEKVRADKDREANDGFDGSWVAHPDLVPIAMESFDRVLGDKPNQKDRLREDVEVKAEDLIAVDSLDAKPTYAGLVNAVQVGIRYIEAWLRGLGAVAIFNLMEDAATAEISRSQIWQWINAGVVLDNGEQVTAELARKVAAEELAAIRAEIGEEAFAAGNWQQAHDLLLKVSLDEDYADFLTLPAYEQLKG
>NZ_CP053109.1|WP_171116848.1|1537199_1537475_-|SelT/SelW/SelH-family-protein
MGEDQRVQIEYCTQCRWLPRAAWLAQELLTTFEAELTELSLKPGTGGVFVVRVNDEVVWDRREQGFPEPTAVKRLVRDRVAPGKSLGHSDE
>NZ_CP053109.1|WP_171116850.1|1537528_1538440_-|hypothetical-protein
MRDVTATRYIEPLRSGGSVPGVVEADDLGTYVVKFTGSAQGRKALVAEVIVGELARALGLRFPELVLVHFDPAIAGHEEHQEVRDLHTSSVGVNLGMDYLPGARDFTPEVAKTFRVDPLEAGRIVWLDALTVNVDRTVHSSNLMIWPTLGIAPPRLWLIDHGAALVFHHRWDLSAPEKAYDFRHHALGHYAPDVRAANAELAPKVTEELLREIVSEVPDAWLLGELDFATPAEVREAYVGYLHARVRASDVWLPTDFPTREEIAAEEALRAARTQRGRPNWLKQVPDLHGKPAAEQDWSVHPG
>NZ_CP053109.1|WP_171116852.1|1538505_1539579_-|NAD(+)/NADH-kinase
MRVSRLGLVVHGGRPEALEAARVVRSWSTEHAVRCTDIDVWQDGGRRSAREEVEAAGDPELIVTLGGDGTFLRGARLAAVNDALLLGVNVGRVGFLTEVPASDVGTALDAVRDDRLGIDSRMLLALRASRRLEVPAGMEAWVRYGRGPLLPPPQVRPDCAVDDEWGTPLDVTALNDVVLEKLARDRQVSVGVYVSGRLLASYSADALLVATPTGSTAYSFAAGGPVVSPRVDALVFTPVAPHMAFDRSVVTAPDEPVGLRILERSGPAAVSIDGQLRGVLDSGDWIGVYAAPQRLRAVRLGPMDFYGRLRERMNLTDAPAAVADGSPAPLWSVTTPPPGDLAHLALLTVQDGSSPLL
>NZ_CP053109.1|WP_171116854.1|1539725_1540376_-|NAD(P)H-dependent-oxidoreductase
MATLLHIDSSVFPGEASSSRAVTDAFRKTWQEQHPDGTVIYRDLAANPVPHITAHAHTAGFADPDTHTAEQAAAFAARVKLIEEVEQADALLIGAPMYNYTIPSTLKAWLDNVILFGRTVGENPSAKGTPVTVVASRGGSYAPGTPKEPFEYVQNYLRAILSDSLALDLDFIVPELTMAPHNPAMTQLIPLFEASRDRAFEEATYKAKQLAERLAA
>NZ_CP053109.1|WP_171116856.1|1540499_1540871_+|helix-turn-helix-transcriptional-regulator
MTDVQSHDAGACKRVDEGITRVFQLLGKRWTGPIVSVLVTQPAHFADLRRAIPGISERMLSDRLSELGTAGLVVRQVDEGPPLRVSYRLTEAGAALEPALQELGEWAKKHLPATRPAAASTHK
>NZ_CP053109.1|WP_171116858.1|1541186_1541627_+|hypothetical-protein
MSKLIRRVATSTVSVALAGIALVGTAGSASAEPLSTSRDRQDTGVGVTERRTADHHVAVRYGERHDRDGRRHDRNGQRRWHQQKDDRGYWYYSPDRRHHYRYDGHRLVRWVDGRWVVIMVTDRLHDVDDWYFDQLRYADQHDGHKG
>NZ_CP053109.1|WP_171116860.1|1541658_1544166_-|SpoIIE-family-protein-phosphatase
MSATHSTGSGRPVHGPVTRERIHVLVDRQGRLVRWSPAAERLLGYPEDAVQGRSALGLLAGPAADGRSPVSGEDFAVALRHRDGGLVRCRLAVRPQRAGDAGTGWEVLLAPAEEDGTAEAERALLETLFTLSPMGLFLLDPQLRLLRFNPAAEGMQGTSVAEAVGRRPTEVWPGLAVQTVERAMKEVLATGRPAIGVEKRVRPPGDPHHDHVYSASLFRLQDAQGRILGVADATVDVTERHLAHERLTVLAQASTRIGATLDALDTARGLAEVSVPVPADSVAVEVLAGVLAGEELEAGPVRPGTVLRRAACHSRDDEPSGTAAGHDGPLSAAASGEALADLEPRLVDPLCSLGQEILRCMRTPAGAGEDADAGKDADAGKGKNADARQEVHSLIVAPLVAQDRALGLATFCRWGERRPFGPDDLTLVAQLARRTAESLDNARRHLREHNSLAALQHILRPGGLPPQQALEVAHAHVSAGSGGDWVDALPLSGARLALVAGRVRGRGIQSAAAAGRLRAAVHTLSDLDLEPDELLARLDDIVRGPGRANGFAGSGDRPSPARDTERSAHGQLCGATCLYLIYDPVSRRCSVSTAGHPWPVVVHPDGTVRRVLAPVADALCCPGGPFGREDFDVPEHSTLVLYTPGLLQPERPAPGEEREQEPDDAGRDRLTALLTHAPDSVQATCRTLTDALVPPVPRDDAAVLVARTHALDRSHVASWDLPSDPAMVSTARSLATRQLAAWDMSEAAFVTELIVSELVTNAIRYGEPPVTLRLIRSHVLTCEVSDGSSTAPRLRHARTTDEGGRGLLLVARSSDRWGTRYTEDGKIVWVEQSTD

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Crispr_ID: NZ_CP053109_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053109_2

2571122-2571343

Orphan

Consensus_repeat	Method
CAACAATAACAACAACAA	CRT

5 spacers

The CRISPR arrays of NZ_CP053109_2

>merge|NZ_CP053109|2|2571122-2571343|CRT
CAACAATAACAACAATAACGGCGGTGGTGGGGGCGCCAACAACAATAACAACAACAATAATAATGGGGGCGGTGGCGCGAACAATAACAACAACAATAACAACGGGGGTGGCGGCGCGAACAACAACAACAATAACAACAACGGGGGTGGCGGCGCGAACAACAACAATAACAACAACAATGGCGGCGGTGGGGGTGCGAACAACAACAATAATAACAACAA

>NZ_CP053109|2|2|2571122-2571343|CRT
CAACAATAACAACAATAA	CGGCGGTGGTGGGGGCGCCAA
CAACAATAACAACAACAA	TAATAATGGGGGCGGTGGCGC
GAACAATAACAACAACAA	TAACAACGGGGGTGGCGGCGCGAACAACAA
CAACAATAACAACAACGG	GGGTGGCGGCGCGAACAA
CAACAATAACAACAACAA	TGGCGGCGGTGGGGGTGCGAACAA
CAACAATAATAACAACAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053109.1\|WP_171112769.1\|2587549_2589745_-\|NAD-dependent-DNA-ligase-LigA	unknown	unknown	gnl\|CDD\|236137
NZ_CP053109.1\|WP_171112775.1\|2581269_2582784_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	unknown	unknown	gnl\|CDD\|235489
NZ_CP053109.1\|WP_171112786.1\|2569600_2569948_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171111891.1\|2570028_2570295_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171112792.1\|2563829_2564030_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171112799.1\|2557068_2560113_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|236645
NZ_CP053109.1\|WP_171112790.1\|2564067_2567142_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226415
NZ_CP053109.1\|WP_004925108.1\|2584537_2584834_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	unknown	unknown	gnl\|CDD\|178810
NZ_CP053109.1\|WP_171112788.1\|2567222_2567408_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171112771.1\|2585055_2587290_-\|bifunctional-diguanylate-cyclase/phosphodiesterase	unknown	unknown	gnl\|CDD\|238923
NZ_CP053109.1\|WP_171112794.1\|2562626_2563829_+\|PQQ-dependent-sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|369642
NZ_CP053109.1\|WP_171112772.1\|2583035_2584532_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	unknown	unknown	gnl\|CDD\|234572
NZ_CP053109.1\|WP_171112783.1\|2576728_2577295_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171112777.1\|2580393_2581173_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|225139
NZ_CP053109.1\|WP_141311504.1\|2582799_2583039_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171112779.1\|2577931_2580190_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP053109.1\|WP_171112781.1\|2577330_2577954_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_CP053109.1\|WP_171112797.1\|2560531_2561482_-\|2-hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240643
NZ_CP053109.1\|WP_171112795.1\|2561557_2562556_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381302
NZ_CP053109.1\|WP_171112801.1\|2554977_2556825_-\|acetolactate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|236098

Protein	Function_ID	Function_description	E-value
NZ_CP053109.1\|WP_171112769.1\|2587549_2589745_-\|NAD-dependent-DNA-ligase-LigA	gnl\|CDD\|236137	PRK07956, ligA, NAD-dependent DNA ligase LigA; Validated.	0
NZ_CP053109.1\|WP_171112775.1\|2581269_2582784_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	gnl\|CDD\|235489	PRK05477, gatB, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB.	0
NZ_CP053109.1\|WP_171112799.1\|2557068_2560113_-\|EAL-domain-containing-protein	gnl\|CDD\|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	4.50971e-67
NZ_CP053109.1\|WP_171112790.1\|2564067_2567142_-\|AAA-family-ATPase	gnl\|CDD\|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	2.01665e-37
NZ_CP053109.1\|WP_004925108.1\|2584537_2584834_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	gnl\|CDD\|178810	PRK00034, gatC, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC.	4.2316e-38
NZ_CP053109.1\|WP_171112771.1\|2585055_2587290_-\|bifunctional-diguanylate-cyclase/phosphodiesterase	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	3.48829e-103
NZ_CP053109.1\|WP_171112794.1\|2562626_2563829_+\|PQQ-dependent-sugar-dehydrogenase	gnl\|CDD\|369642	pfam07995, GSDH, Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.	1.01189e-82
NZ_CP053109.1\|WP_171112772.1\|2583035_2584532_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	gnl\|CDD\|234572	PRK00012, gatA, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA.	0
NZ_CP053109.1\|WP_171112777.1\|2580393_2581173_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|225139	COG2230, Cfa, Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane].	5.43424e-24
NZ_CP053109.1\|WP_171112779.1\|2577931_2580190_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	9.91259e-97
NZ_CP053109.1\|WP_171112781.1\|2577330_2577954_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	6.92865e-26
NZ_CP053109.1\|WP_171112797.1\|2560531_2561482_-\|2-hydroxyacid-dehydrogenase	gnl\|CDD\|240643	cd12166, 2-Hacid_dh_7, Putative D-isomer specific 2-hydroxyacid dehydrogenases. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	3.11395e-142
NZ_CP053109.1\|WP_171112795.1\|2561557_2562556_+\|aldo/keto-reductase	gnl\|CDD\|381302	cd19076, AKR_AKR13A_13D, AKR13A and AKR13D families of aldo-keto reductase (AKR). Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.	1.29249e-132
NZ_CP053109.1\|WP_171112801.1\|2554977_2556825_-\|acetolactate-synthase-large-subunit	gnl\|CDD\|236098	PRK07789, PRK07789, acetolactate synthase 1 catalytic subunit; Validated.	0

>NZ_CP053109.1|WP_171111891.1|2570028_2570295_+|hypothetical-protein
MTTLPADPQLSSRTEYEAALQTLSEASQAYYGDGDSPLDRVPGRTTASARFRSDSAAWPSRLRSSAAPPVQYEVTALTCGWAARRLVS
>NZ_CP053109.1|WP_171112786.1|2569600_2569948_+|hypothetical-protein
MTTAPARLNPEQLAERLDALGDTAGAVFVRALAREAEVLRGERDALATFARTIAALSGNGRTANTDLSGQAHEALDTLRVTGRCPVSESRRHSAKRSGSSGLTRCGHCHARLRRS
>NZ_CP053109.1|WP_171112788.1|2567222_2567408_-|hypothetical-protein
MYAYELQQIRSAELIRRAEHERLVREVIRSGRAARREAAERAAGNEADTRRPRRNRSPRTA
>NZ_CP053109.1|WP_171112790.1|2564067_2567142_-|AAA-family-ATPase
MLGLVETRSVSPVFVGRAEELDTLNDALARAAGGGTSQALSTGGEPQALLLGGEAGVGKTRLVEEFSTAAARKGAVVALGGCVEIGADGLPFAPFSTALRALRRELPDELAAAAAGQEEELARLLPELGDTGTGRPDEEGMARLFELTARLLERVAADRTVVVALEDLHWADASTRHLLAYLFRTLRTGRLVVLATYRSDDIHRRHPLRPLLAELDRLRTVQRIELARFNRAEVARQIAGIHAAEPDPAQVDEIFQRSDGNAFFVEELAVAAHEGCRTGLTDSLRDLLLVRVEALPESAQRVVRIVAEGGSTVEYRLLAAVAGLAEDDLIEALRAAVNANILLAAATGDGYRFRHSLVREAVADDLLPGERSRLNRRYAEALEADPGLVPADQRVMRLASYWYHAHDAAKALPAVLDASVAARRRHAYSEQLRLLERAMELWDPAPEDVRAALRPAGYTDVYRAPDGGDQANTALRYLDLMAAAAVASRFCGERERALKITKRALRLLEDEDDPLLAAWFWVQRSRLVQAKARDDGWKELATAQELVRGLPPSEVHAEVLTNVAGWSMLHQPGAEALAAAERAVEYARMVEAREVELNARVTRGVLLVDAGDIEAGLAEMYEVKEQSLAGSFTHVAGRTYVNLPSELEAVGRSLEAAGILEEGTGFARKYGLLDTEAWVWGNLSDSLFSLGRWDESAEAASNALRRGHSAKPQGTAALCLANVALARGDAAEAGRQLAAAHGYFGTHDPMPQQWLPLAFIAIGVAASEGRILDARGELDRALDAGIPPGTQRYGWKLLLAAATAEADSRSLPAARQGREETLERIFSTVKRLTTGAPIWVAHEKWVRAELQRAEGIADPDTWSEVVTAFERLERPYDLARVRHRLAEALLTAGGEDDRDRAIELLRLAHAVADHLGARPLADAACLLAQRARLSLRQAPQQSPAADPVQALGLTSRERDVLRLVSIGRTNRQIAEELFISPKTASVHVSNILGKLGVSGRGEAAALAHRLGLFPPETLGAPTAG
>NZ_CP053109.1|WP_171112792.1|2563829_2564030_-|hypothetical-protein
MFNVFEELFAPGRKHTRDEQNRLELTREDVGDGDPGRGPIDLASGKVVVRPPEPTENEQPASEGPR
>NZ_CP053109.1|WP_171112794.1|2562626_2563829_+|PQQ-dependent-sugar-dehydrogenase
MTSRTRRVEGTMIVQRRAVTAVLAAATLLLTAGCSSDDGRGGPPQGGATPSGTSAQASPSGAAAEEPPPAKGSVKVVRTVTEGLNSPWGLAALPDGDLLVSSRDEATITRVDTETGRKTEVGEVPGVSPAGEGGLMGLALSPDYASDHMVYAYFTSASDNRIVRMLYDEQKPSGEQLGAPDTVFRGIPKGFIHNGGRIAFGPDKMLYAGTGESGEEGLSQDRESLGGKILRMTPEGEPAPGNPFPDSTVYSYGHRNVQGLAWDSKQRLFAAEFGQDTWDELNAIEPGGNYGWPEVEGRSDDSAYRNPIAQWSTDEASPSGIAYAEGSIWMAGLGGERLWRIPLDGTQTSADPQAFLEGEYGRLRTVLAADGNKLWLTTSETDGRGSPGEGDDRILELEVS
>NZ_CP053109.1|WP_171112795.1|2561557_2562556_+|aldo/keto-reductase
MEGRTIGAAALAVGAVGLGCMPMSWAYSTSRQRGDESLRAVHRALDLGSTLLDTADMYGPFTNELLVGRVLKERRSDAFVSTKVGLLVGEQHIVANGRPGYVKRACDASLRRLQTDVIDLYQLHRADPEVPVEETWGAMAELVRAGKVRALGLCAVGARGGRRSGTRLHDATIRQLQRVQQVFPVSAVEAELSVWSPEALDALLPWCEARGIGFLAAMPLGNGFLTGTLTPGEGFEPDDMRARHPRFTAEMMAANQPIVAGLRRVAARHGEDVTPAQVALAWVLAQGRHVVPVPGTKRERWVTENARAVGVRLTAEDLAEVSGLPGAQGSWD
>NZ_CP053109.1|WP_171112797.1|2560531_2561482_-|2-hydroxyacid-dehydrogenase
MTADVWLPIPPEDIEGLPDGPEYRFWNGGETFPADPADCSFYVVPYMKPTGVGVRPMPEMTSVQVVQTLSAGIDHVEPGLGHLPPGVRLCNARGVHEASTAELALALILASLRGIPDFVRAQDRGEWIGGFRPALADRTVLIVGYGSIGAAIEDRLAPFELARVARVARSERTTARGPVHPLTELPVLLPEADVVILSTPLTETTRGLVNDEFLSRMKDGALLVNIARGPVVDTKALLTELESGRITAALDVTDPEPLPPSHPLWQAPGLLISPHVGGPTSAFLPRAKRLLVDQLHRFVNREPLRNVILTTGARGA
>NZ_CP053109.1|WP_171112799.1|2557068_2560113_-|EAL-domain-containing-protein
MNAPSPSTTTLDRALRPQRARGALLPRPQGVRSGSGMYPQLVLVLLCAGYAVGSAVGWGSGQLALIMGDFGLSAAAGAAAVSCFLYAHSRRVRFRSAWLLFALSSAMAALGNGVWGWYEVVLGQPVPSPSYADLFFLCFAPPAIVGLLVLAKRPVTKAGWVCLALDAWLIGGSLVTLSWSLALAQAAKGGGAGVAHTALSLAYPLLDIALVSMVLALHFRRSGANRSAVNTAIGALALTVMCDALFTSPLMHNNYHSGQLLDAGWFAGSLLLAYAPWTAPRPGQPGDEPHTRVVHEHLPGQRGTTHPHPPAQQGEPGRYPATRPLTGSLAALTPYLAAAVCTLGILYNVLNGRSVDRVVLLTGGTVVLALVVRQGIMLLDNITLTQELAQKENHFRSLVQGSSDVIMIAAPNGILRYVSPAAAGVYGRPADELVGTELAELIHPEDLGCVVHEVRRFLAASPLEEPTTRIECRFRSGEGGWLNVESTVNRHHGGLIFNSRDVTERVRLQAQLQHNAEHDPLTDLPNRALFTRRVQQALSGRRSTDRGAALRGTAVLFIDLDGFKAVNDTIGHQAGDELLVQAAHRLQEAVRQGDTASRLGGDEFAALIVGDGTRDRAARERNILELADRLRVTLSQPYLIDGNDVRVAASIGVAFAEPGLGAGELLRNADLAMYRAKSAGKGRVELYKPQMQQDVVRKAELATRLRAALHDGEFTLLHQPVVCLEDGRITSVTAQARWRSSQGVLFTPAEFLRVAEDSDKTAELGRWTLAEAVERAAERAATGHAVPVAVRMAARRLLDRSMPLGSVEALLTRHGLPSGALVIELSDIDAKIPLDDLERRLGTLRRLGVRIALDGFGSGSPAAITALRRLPLDVLKLDRGLVEGVVESARLHKITSGLLRIAGDLGLQSVADGVDLPEQVVALRAMGCTHGQGMAFSGPLDEYRLRRALGSGHFPVPHGPAEPAFAGGGAGTYSGGVTTVFGGGTPVGTPVATPVGPSLVTPLRSHNETPVPPT
>NZ_CP053109.1|WP_171112801.1|2554977_2556825_-|acetolactate-synthase-large-subunit
MTEQATGAHHPQPRPRSGGQQSAPEHVTGAQSLIRSLEEVGADTVFGIPGGAILPAYDPLMDSGKVRHVLVRHEQGAGHAATGYAQATGKVGVCMATSGPGATNLVTPIADAHMDSVPLVAITGQVASKAIGTDAFQEADIVGITMPITKHNFLVTKAEDIPRVIAQAFHIAATGRPGPVLVDIAKDALQAKTTFSWPPTMDLPGYRPVTKPHAKQIREAAKLITSAKRPVLYVGGGVIKAKATGELKVLAELTGAPVTTTLMALGAFPDGHPLHVGMPGMHGAVAAVTALQKADLIVALGARFDDRVTGKLDSFAPYAKIVHADIDPAEIGKNRAADVPIVGDAREVIADLIQAVQKEHSEGHRGDYAAWWKDLNRWRDTYPLGYDQPEDGSLSPQQVIERIGQLAPEGTIFAAGVGQHQMWAAHFIQYDKPATWLNSGGAGTMGYAVPAAMGAKAGVPERTVWAIDGDGCFQMTNQELTTCALNNIPIKVAVINNGALGMVRQWQTLFYNQRYSNTVLHSGPDDVNPQARGTRVPDFVKLSEAMGCYAIRCEDPADLDKVIEEANSINDRPVVIDFIVHEDAMVWPMVAAGTSNDEIMAARDVRPDFGDNEDD
>NZ_CP053109.1|WP_171112783.1|2576728_2577295_-|hypothetical-protein
MGTKTVDETPAETGAEAGAKTDEERVEEAADATTTEADTDPGTEDGDAQPEASHDAGPSGVGQGAGAVVAVALGIVSLTGSWVGTVASARESLIGQLQTSQSSSVATMVKEGYGDAWAANALWAGVFALAALIVGVVVLARPAFGAPGRPQAPWIKSVAWAGVSLGVIGLFLAVLKYTGVLLGLPATG
>NZ_CP053109.1|WP_171112781.1|2577330_2577954_-|GNAT-family-N-acetyltransferase
MYAISLGDDDGARLRPLEPWHAEEFLAHLDRGRDFITRHIPFGSKATDLDSARALLQAYADKRAADSGSLHGIWLDGKLVGGVLFRVFDAATGVCEIGVWLEPAATGRGLVTRASRVLIDWAFDERGMHRVEWHAASDNTASINVARRLGMTREGVLRESYPWRGVRQDYEIWAVLAPEWAKARARGDADAGTRVERSQRSFAHNDH
>NZ_CP053109.1|WP_171112779.1|2577931_2580190_-|MMPL-family-transporter
MAALARWCVRNRLVVVLLWLLACGGVTAAATATGTAYSNDYQVPGTESERAGQLLKEGFPELGGAAGTVVWHTENGSVRAADVEQTMTRTLHAIAQLPGVATVVSPYDGQGAGRISEDGRTAYATVAFRDPSQDIDESEAQAVVDTAKGAEADGLQVELGGTAIGLTDPSGGHLAEVVGVGVAAVVLFLAFGSLAASLLPIATALVGVGTAYAGIVLLGHAMTVADFAPMLGMLIGLGVGIDYALFIVTRHRRGLKRGLDVTEAATTAVATTGRAVVFAGATVCIALLGMLILRLGFLNGVAIAASLTVVLTVAASVTLLPALLSFIGMRALSRRERRRLEEHGPEPELPTGFAARWSAFVERHPKKLGAVALAVITLLALPTLSLRLGTSDQGNNPASTTTRQAYDLLADGFGPGVNGPLTLVTEIQGAEDRLAVDSLGSSLRATEGVAAVTPVTFDSGGHTAYLTVVPESSPQSASTSDLVDRLRTEVLPRAEAGTSLDVHVGGVTAAYDDFAEVIVDKLPLFVGVVIGLGCVLLLLAFRSVGIPLKAAAMNVAAVAASFGVVVAIFQWGWGSELLGLGRAGPIEPFLPVIMVSVLFGLSMDYQVFLVSRMYEEWLETGDNRRSVRVGLAETSRVINSAAVIMISVFLAFVLSGDRVIAMFGIALAAAVALDAFVLRTLLVPALMHLLGGANWWLPRWLDRHLPRISIEPPESRAEQENLTDVDAEREKLTDVVDVLEKERRSDVRDIPG
>NZ_CP053109.1|WP_171112777.1|2580393_2581173_+|methyltransferase-domain-containing-protein
MPDLTERLTNDRYPRSNQYDARWVVDHQMGPNPLWLLEWLAPALRLDSLPPHARVLDLGCGRALTSVFLAREYDVQVTAADLWIKPDENAERLAAAGVADRVLPVHAEAHDLPFGEGTFDAIVSIDAYQYFGTDDLYLPTLMRLVKPGGRIGVVVPALRDEPDGTEPPEHLKPWWEPDFWCFHSADWWRRHWTRGGAVEVESADWLNDGWRDWLLWCDVVAEESPEEFHRTMSRRVGEMLRVDEGRALGFVRLVGQRPV
>NZ_CP053109.1|WP_171112775.1|2581269_2582784_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB
MTTTTDLVSYEDALASYDPVMGLEVHVELGTKTKMFCGCSTALGQDANTQTCPVCLGLPGALPVVNATGVESAIKIGLALNCEIAEWCRFARKNYFYPDMPKNFQTSQYDEPIAFNGYLDVQLEDGETFRVEIERAHMEEDTGKSTHVGGATGRIHGALHSLLDYNRAGIPLIEIVTKPIVGAGERAPEVAKAYVRELRELIRALGVSEARMEMGQMRCDVNLSLMPKGADKFGTRSETKNVNSLRSVERAVRFEIQRHAAVLGDGGTVIQETRHFHEDTGTTTSGRTKEEAEDYRYFPEPDLVPVAPSREWVEEIRASLPELPLVRRNRLREEWGISATDMQAILNAGALDPIVATIDAGADAAAARKWWMGELARSANESGKALDELAITPAQVARVAELVSKGDLNDKLARQVIEGVLAGEGIPDEVVDKRGLKVVSDEGALTTAVEEAIAGNPGIADKIRGGKVAAAGALVGAVMKATRGQADAARVKELILQKLGVSEG
>NZ_CP053109.1|WP_141311504.1|2582799_2583039_-|hypothetical-protein
MSALSKAKGFKKSKSGTYLSMAATAFGAIGVAKQIKKARAENDTLRLVDAVVTAAGVVTGLAMLYRELKRLGDDDVLLG
>NZ_CP053109.1|WP_171112772.1|2583035_2584532_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA
MTDAIIKLTAAEIAARIASGELTAVEVTEAHLARIEAVDEKVHAFLHIDREGALAAARAVDEKRAKGEKLGPLAGVPLALKDIFTTEGIPTTVGSKILEGWIPPYDATLTKKLKDADVVILGKTNMDEFAMGSSTENSAYGPTGNPWDLTRIPGGSGGGSSAALASYQAPLAIGTDTGGSIRQPAAVTGTVGVKPTYGAVSRYGMVAFSSSLDQGGPCARTVLDAALLHEVIAGHDPLDSTSIDAPVPPVVEAARNGSVEGMRVGVVKQFRGEGYQAGVIQRFDESVTLLKELGAEIVELDCPSFDLALSAYYLIAPSECSSNLARFDGLRYGLRTGDDGSRSAEEVTSLTREAGFGAEVKRRIMLGTYALSSGYYDAYYGSAQKVRTLIKQDFDKAFEQVDVIVSPTTPTTAFPIGERADDPMAMYLADLCTIPTNLAGNAAMSLPCGLAPEDNLPVGLQIIAPAMQDDRLYKVGAAVEAAFVEKWGHPLLEEAPSL
>NZ_CP053109.1|WP_004925108.1|2584537_2584834_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC
MPGITREEVAHLARLARLELKPEELDHFAGQLDDIIGAVARVSEVADQDVPPTSHPLPLTNVMRPDEVRPSLTPEQALSGAPAQEQQRFKVPQILGEE
>NZ_CP053109.1|WP_171112771.1|2585055_2587290_-|bifunctional-diguanylate-cyclase/phosphodiesterase
MEPTESAAPYSRLRRMAGAWRGGLRSAWRASAAATRDHDAGQRIVPAGCDAAALTAGQTAGLPGVDAERHLSWPALPAAVVAAAGFALGAGFLRAFTGHHPLFPSGTAGWSLAVLTGIIVGHLVALGRARWWGGTGSGAALTLAVLLLYGWVSAGLVSLTVVVLVGIARRHRWRQGVLHGAVDILGIGAGALLLAAFGRVPSVENPWHPATWTLYTATEVILVATAYLAVSRTLLWYLHAPRPGGLPTIARTALVRHGLVAVALFGIAPLICVVAVAKPILLPLFAIPLIALDSTLWIARARAEEQLRDPLTGLPNRQWLLERIWTALDDAERIDARAALMLIDLDRFRSVNDTLGHLAGDRLLLQTADRLRLALPRGAEAARLGGDEFAVLLPVADSTTSATRIARGLVTALSSPLDLDGLTLVLEASAGVAVFPDHALDAEGLLRRADVAMYQAKRDRTGVEVYESKRDSNTPDRLGLLADLRRALDAHEVELHYQPKVRFDGQVAGLEALVRWVHPERGKVPPDEFIAIAESSGLMPQLTEYVLETALGQVAQWRSQGLFVPVAVNVSPRDVHTPGFAGSVAARLARHGVPAGALQLEITEHVLLEDPQRAADTLAGLTGHGVKMSLDDFGTGYSSLVHLKRLPVSELKIDRSFVARLAVDAEDAEIVRCTVDLAHSLGLLVVAEGVEDDETWERLRDLRCDAVQGWLVAAAMPPEETTAWLRARGARGWQRPKAALPAAD
>NZ_CP053109.1|WP_171112769.1|2587549_2589745_-|NAD-dependent-DNA-ligase-LigA
MAGDKQAESTAVPAEARERHAQLAEQVEEHRFRYYVKDAPVVSDAEFDQLLRSLEELEEEYPELRTPDSPTQKVAGSYETDFTAVEHRQRMLSLDNTFNDDELAAWADRIARELGAQDYHFLCELKVDGLAVNLTYEHGRLTRAATRGDGRTGEDITPNVRTIAEIPDRLKGDRVPDLVEIRGEVYFPMEKFEELNRRLVEAGDKPFANPRNAAAGSLRQKDPRVTATRPLHMVVHGIGALEGFSGLTRLSQAYDLLKEWGLPTSLHNKVVDDLEGVREFIAYYGENRHSVEHEIDGVVVKLDEIRLQGRLGSTARAPRWAIAYKYAPEEVNTKLVNIRVGVGRTGRVTPYAQVEPVTVAGSEVEFATLHNQDIVKAKGVLIGDTVVLRKAGDVIPEILGPVVDLRDGTEREFVMPSECPECGTALRPMKEGDVDLRCPNSRACPAQLRERLFYLAGRKALDIEHFGYVAAAALTGPLEPEEPPLKDESDLFDLTVEQLLPIKAYVLDQDSGLPKRDPKTGEEKIATVFANQQGEPKKNALAMLENIAAAKQRPLARILTGLSIRHVGPVAAEALAREFRSIDRIEQATEEELATTDGVGPIIAASLKEWFAEDWHREIIRKWKAAGVRLEEESTGEDEGPRPLEGLTVVVTGTLEHFTRDGAKEALQTRGAKVTGSVSKKTSFVVVGDSPGSKYDKAMQLKVPVLNEEGFNVLLQQGPEAASEVALPTGE

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Crispr_ID: NZ_CP053109_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053109_3

3479070-3479160

Orphan

Consensus_repeat	Method
ACCGGCGTCACCCCGGCGACCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP053109_3

>merge|NZ_CP053109|3|3479070-3479160|CRISPRCasFinder
ACGGGCTGCACATCGGCGACCACCCCGTACGCCAGCGCGGCCGCGGCGCCCACCGCGTGCCCGGCGATCGGGGCGACCCCGGCCGCGGCCC

>NZ_CP053109|3|1|3479070-3479160|CRISPRCasFinder
ACGGGCTGCACATCGGCGACCACC	CCGTACGCCAGCGCGGCCGCGGCGCCCACCGCGTGCCCGGCG
ATCGGGGCGACCCCGGCCGCGGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053109.1\|WP_171117600.1\|3466286_3468179_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP053109.1\|WP_171117602.1\|3465328_3465787_+\|peptidoglycan-binding-protein	unknown	unknown	gnl\|CDD\|366659
NZ_CP053109.1\|WP_171117587.1\|3485550_3486693_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|336785
NZ_CP053109.1\|WP_141312482.1\|3475348_3476233_-\|succinate--CoA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|180194
NZ_CP053109.1\|WP_171119168.1\|3488305_3489931_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171117604.1\|3464710_3465271_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366659
NZ_CP053109.1\|WP_171117590.1\|3476261_3477443_-\|ADP-forming-succinate--CoA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234813
NZ_CP053109.1\|WP_171117585.1\|3490228_3490645_-\|cobalamin-B12-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|239022
NZ_CP053109.1\|WP_171117582.1\|3492410_3494114_+\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NZ_CP053109.1\|WP_171117596.1\|3468579_3470145_-\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234854
NZ_CP053109.1\|WP_171117598.1\|3468192_3468438_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235300
NZ_CP053109.1\|WP_171117580.1\|3494172_3496656_-\|DNA-helicase-PcrA	unknown	unknown	gnl\|CDD\|273429
NZ_CP053109.1\|WP_171117591.1\|3474022_3475177_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|132028
NZ_CP053109.1\|WP_171117586.1\|3486826_3488182_+\|SWIM-zinc-finger-family-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171117578.1\|3497107_3498292_+\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NZ_CP053109.1\|WP_171117584.1\|3491341_3492235_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|224001
NZ_CP053109.1\|WP_171117589.1\|3481811_3482993_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|283431
NZ_CP053109.1\|WP_171117588.1\|3483033_3485460_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171117593.1\|3471126_3471921_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171117595.1\|3470141_3470780_-\|phosphoribosylglycinamide-formyltransferase	unknown	unknown	gnl\|CDD\|235544

Protein	Function_ID	Function_description	E-value
NZ_CP053109.1\|WP_171117600.1\|3466286_3468179_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	5.61085e-73
NZ_CP053109.1\|WP_171117602.1\|3465328_3465787_+\|peptidoglycan-binding-protein	gnl\|CDD\|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	8.97726e-09
NZ_CP053109.1\|WP_171117587.1\|3485550_3486693_-\|AAA-family-ATPase	gnl\|CDD\|336785	pfam07728, AAA_5, AAA domain (dynein-related subfamily). This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.	1.72885e-41
NZ_CP053109.1\|WP_141312482.1\|3475348_3476233_-\|succinate--CoA-ligase-subunit-alpha	gnl\|CDD\|180194	PRK05678, PRK05678, succinyl-CoA synthetase subunit alpha; Validated.	0
NZ_CP053109.1\|WP_171117580.1\|3494172_3496656_-\|DNA-helicase-PcrA	gnl\|CDD\|273429	TIGR01073, ATP-dependent_DNA_helicase_PcrA, ATP-dependent DNA helicase PcrA. Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP053109.1\|WP_171117604.1\|3464710_3465271_+\|hypothetical-protein	gnl\|CDD\|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	0.00526739
NZ_CP053109.1\|WP_171117590.1\|3476261_3477443_-\|ADP-forming-succinate--CoA-ligase-subunit-beta	gnl\|CDD\|234813	PRK00696, sucC, ADP-forming succinate--CoA ligase subunit beta.	0
NZ_CP053109.1\|WP_171117585.1\|3490228_3490645_-\|cobalamin-B12-binding-domain-containing-protein	gnl\|CDD\|239022	cd02071, MM_CoA_mut_B12_BD, methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom with a group attached to a neighboring carbon atom. This family is present in both mammals and bacteria. Bacterial members are heterodimers and involved in the fermentation of pyruvate to propionate. Mammalian members are homodimers and responsible for the conversion of odd-chain fatty acids and branched-chain amino acids via propionyl CoA to succinyl CoA for further degradation.	3.65919e-64
NZ_CP053109.1\|WP_171117582.1\|3492410_3494114_+\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	5.49042e-37
NZ_CP053109.1\|WP_171117596.1\|3468579_3470145_-\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	gnl\|CDD\|234854	PRK00881, purH, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional.	0
NZ_CP053109.1\|WP_171117598.1\|3468192_3468438_-\|hypothetical-protein	gnl\|CDD\|235300	PRK04447, PRK04447, hypothetical protein; Provisional.	0.00569634
NZ_CP053109.1\|WP_171117591.1\|3474022_3475177_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	8.6353e-11
NZ_CP053109.1\|WP_171117578.1\|3497107_3498292_+\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	5.3694e-34
NZ_CP053109.1\|WP_171117584.1\|3491341_3492235_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|224001	COG1075, LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only].	6.843e-18
NZ_CP053109.1\|WP_171117589.1\|3481811_3482993_-\|VWA-domain-containing-protein	gnl\|CDD\|283431	pfam05762, VWA_CoxE, VWA domain containing CoxE-like protein. This family is annotated by SMART as containing a VWA (von Willebrand factor type A) domain. The exact function of this family is unknown. It is found as part of a CO oxidising (Cox) system operon is several bacteria.	3.92829e-52
NZ_CP053109.1\|WP_171117595.1\|3470141_3470780_-\|phosphoribosylglycinamide-formyltransferase	gnl\|CDD\|235544	PRK05647, purN, phosphoribosylglycinamide formyltransferase; Reviewed.	1.6394e-111

>NZ_CP053109.1|WP_171117590.1|3476261_3477443_-|ADP-forming-succinate--CoA-ligase-subunit-beta
MDLFEYQARDLFAKHDVPVLAGEVIDTPEAAREITERLGGKSVVKAQVKVGGRGKAGGVKLAATPDEAVARATDILGMDIKGHTVHKVMIAETAPEILEEYYVSFLLDRANRTFLSIASVEGGVEIEEVAATRPEAVAKIAIDPIDGVDEAKAREIVEAAKFPAEVADKVVNVLVKLWDTFIKSDALLVEVNPLAKVASGDVIALDGKVSLDDNAEFRHPEYEELHDKAAANPLEAAAKEKNLNYVKLDGEVGIIGNGAGLVMSTLDVVAYAGEKHGNVKPANFLDIGGGASAQVMANGLEIILGDPDVKSVFVNVFGGITACDEVANGIVQALKLLEDRGENVTKPLVVRLDGNNAELGRQILTDANHPLVQRVDTMDGAADKAAELAAAAK
>NZ_CP053109.1|WP_141312482.1|3475348_3476233_-|succinate--CoA-ligase-subunit-alpha
MAIWLNKDSKVIVQGMTGATGMKHTKLMLGDGTHVVGGVNPRKAGQSVDFDGTEVPVFGTVKEAIEKTGANVSVIFVPEKFTKDAVVEAIDAEIPLAVVITEGIAVHDSASFWAYAGKKGNKTRIIGPNCPGIITPGQSNVGIIPGDITKPGRIGLVSKSGTLTYQMMYELRDIGFSTAVGIGGDPIIGTTHIDALAAFQADPDTDLIVMIGEIGGDAEERAAAFIKENVTKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAQAKKEALEAAGVKVGKTPTETAKLAREILAG
>NZ_CP053109.1|WP_171117591.1|3474022_3475177_+|helix-turn-helix-domain-containing-protein
MTESPVTPLPPPEERRRLREAGALTRAQVASRVGVSKATVRAWESGRTTPDGRKAEAYATLLASLATEAAATAVRTEEQPASGPEPSPESSPGSLPGSPPDSSPVSLPESSPERESGLEPLTPAQAFDALYAFCAPDLVRQAYVLTGRRELARESVERAFQLAWQRWPEVAVDPDPAGWVRLAAYEYALSPWHRFRPRYRHPEPPPADQRDRALLSALLELPPPYRRTLLLYDGVGLDLPETAAETEASTPATANRLMHARQAVASCLPDLADPEELQRRLTDLASTERLRAARPVAVRRGGERRAQFWTRAAIAFTVTLIGATALTLRTAPTQYEPPVPPGETVRGVPPRAAPGPLSYEQLMLREKLRQAMASGEERLVPEAR
>NZ_CP053109.1|WP_171117593.1|3471126_3471921_+|hypothetical-protein
MPDRSLRLLTFPPQSVQGRERSGVLLRERPASPADAPSGDANGDRQDDNPFAPPPEGTPDRPWQPRRPSGDSGDSAGSTGSTGSEGSQGDGGRPAWGSQWSDRQPGRSSGGGFGDRPGGGPERPGGPAPGMRWDPTDPAQRRARYALLAGMWAFFFALFTWTYVALLLGALALYWGISALRTKPRTPSPDTPAGATPARPQAAAAVSGLVTASLAIALVGASFAAQLVYRDYYTCTNDALTNEARQDCSKLLPEQLRDVLGANS
>NZ_CP053109.1|WP_171117595.1|3470141_3470780_-|phosphoribosylglycinamide-formyltransferase
MAAKPVAKRAKRLVVLVSGSGTNLQALLDAIAAEGAEAYGAEIVAVGADRDGIEGLARAERAGLPTFVRKVKDYESREAWDAALAEAVAAYEPDLVVSAGFMKIVGKEFLARYGGRFINTHPALLPSFPGAHGVRDALAYGARVTGCTVHFVDDGVDTGPIIAQGVVEVRDEDDESALHERIKEVERRLLVDVVGRLARNGYRIEGRKVVIQ
>NZ_CP053109.1|WP_171117596.1|3468579_3470145_-|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase
MTATAESNKRAIRRALVSVYDKTGLEELARGLHEAGVELVSTGSTAARIAAAGVPVTKVEELTGFPECLDGRVKTLHPKVHAGILADLRLDSHRQQLDELGVAPFDLVVVNLYPFEETVASGASPDECVEQIDIGGPSMVRAAAKNHPSVAVVTSPERYADVLAAVRDGGFDLAARKRLAAEAFRHTAEYDVAVAGWFAGEYAGEGAEFPEFIGVTYQRKQVLRYGENPHQPAALYTGGCGGLAEAEQLHGKEMSYNNYTDTDAARRAAYDHDEPCVAIIKHANPCGIAIGADVAEAHRKAHACDPLSAFGGVIAVNRPVSKEMAEQVAEIFTEVIVAPDYEEGALEALAKKKNIRVLRCPQAPETSAEFKPIDGGGLAQITDVFQAEGDDPANWTLATGEALSPEELKELAFAWRACRAVKSNAILLAKDGASVGVGMGQVNRVDSAKLAVERAGAERAQGSYAASDAFFPFPDGLEILTEAGVKAVVQPGGSVRDEQVVEAARKAGVTMYFTGTRHFFH
>NZ_CP053109.1|WP_171117598.1|3468192_3468438_-|hypothetical-protein
MLSCACFNPVDIMVAWTGYGLLGVAGLIIGFVCLVGMLLAGMAVVGHVIRRWQGDDHVPGAGGTDEERLGLASFRWESEPD
>NZ_CP053109.1|WP_171117600.1|3466286_3468179_+|protein-kinase
MTDQRPGSPYTPAAGDAALRQAGAKPLEAADPGRIGPYVPLGLLGSGGMGRVYLARPADDSPGLAAVKVIRPEYAEDPEFRRRFEREAAVQARVHTPHAPQLLGTGFDDSLLWMATQYLPGLNLADAVRECGGLGSAGLWRLVAELGQALSALAAAGVVHRDLKPSNVILSLRHAHVIDFGISQAADASSITTTGSRVGTPAFMSPEYLREGRCDTASDVFSLAGTLIYAATGTAPFGDGTGVDVMHRVAFEEPKAEIMAELTVVDPELAAFLSACLAKDPAGRPTPRQLIDAAAAAGHGHAPSWQEPLGGHLLSRQQACEVLERASARQTGHFRAPTEPVASPAPRPAFGPATPPSPYGAPPTPPGPYGTPSTPPAAYGMATPPAHYGTSPQGPPSVGNGASGTRRSGRKPYLAVAAGVAVVAVIVSAFLLTRPEFDETASASPTTSGSTASDNEPGSVSPSPSSSPSSREKEKEKEEGKEKEKGESEGQGEDEQATGGAADGSGGSSGGGTGGAQPTVTVTATSGSGTAGGTGTSPTETATTPAEPPWNTQCTYYSGTALTRYGDKNSRVTQVQCMLVKRGYSVGNAGVDGQFGDGTRAAVKKFQSAKGLDVDGIVGANTWGALRSST
>NZ_CP053109.1|WP_171117602.1|3465328_3465787_+|peptidoglycan-binding-protein
MVRGSSPHIRVGLVTGALTATLLGGALAVAPAASAASYPTCNAVKRVYLSSTVWVRQPYYSGTGSRNCILQYGNSSSAVTALQDALITCYRQDTGGKDGIYGPKTRQAVYNVQTQYRDIANDGIYGPETRKKMGWRVYNNGNATTQCTAPGV
>NZ_CP053109.1|WP_171117604.1|3464710_3465271_+|hypothetical-protein
MNIAMPRIRLTTAVVAATVAAGMLTVSAQPASANVSEGYVKGAYMYQDDFGDEGTLSTGSHAHTNATALWQWILWAEGAKKSNGDAFAHGDIDCWFGSDTKSATISLQRTLKLKSIDGIVGNETFGAVDGNIEWVSSNNDSYPYRTKLRYKGNEHAFFLYRSASGVYKVYIPNVGWKPASYTYANC
>NZ_CP053109.1|WP_171117589.1|3481811_3482993_-|VWA-domain-containing-protein
MTAEAMGVAELDDAGRERLRRWRLVLGSDAADGTGCALGGRDAAMDGALAALYGQGDKPQTGRERAAGLGASAPSVARWLGDIRTYFPSSVVQVMQRDAIDRLGLSALLLEPEMLEAVEADVHLVGTLLSLNKAMPETTKETARAVVRKVVEDLEKRLATRTRATLSGALDRSARINRPRHHDIDWNRTIAANLKHYLPEYRTVVPERLIGYGRASQSVKKEVILCIDQSGSMAASVVYASVFGAVLASMRTISTRLVVFDTAVVDLTDQLEDPVDVLFGTQLGGGTDINRALAYCQSQITRPAETVVVLISDLYEGGIRNEMLKRVAAMKGAGVQFVTLLALSDEGAPAYDREHAAALAALGAPAFACTPDLFPEVMAAAIEKRPLPIPDTA
>NZ_CP053109.1|WP_171117588.1|3483033_3485460_-|hypothetical-protein
MTGVERAGSSGLTGTEPLLFGVRHHGPGSARAVRAALDAARPRVLLIEGPPEADALIPLAGDEDMRPPVALLVHAVDEPGRSAFWPLAEFSPEWVAIRWALEQGVPARFIDLPATHTLVWGSEAEGESAGDGGGVGGGEAGPDADADAGADAGTDAAPQSDVRVDPLGVLAEAAGYDDAERWWEDVVEHRGLGEGDAFAPFAVVEEAMGALREVYGSGGHDRDLVREAYMRLQVRTAQREFGGGVAVVCGAWHVPALRQKVTVAADRALLKGLPKVKVDMTWVPWTHRRLARASGYGAGIDSPGWYGHLFSAPDRPVERWMTKVAGLLRAEDRTVSSAHVIEAVRLAETLAAMRGRPLAGLGETTDAIRAVMCEGSDVPLALVHDRLIVGDVLGEVPDAAPAVPLQRDLARLQRRLRLKPEALERELELDLRKEADAGRSRLLHRLRLLGVVWGEQVVSRGSTGTFRETWRLRWEPELSVRVAEAGVWGTTVLAAATAKAEADAMAAQGLADVTALAERCLLAELPDALPAVMRILADRAALDADVGHLAQALPALVRSLRYGDVRGTDTGALGEVAAGLAERIFVGLPPACAALDTDAAEEMRRHVDAVHTAVGLLGEAPAAGHGDLRGRWHSVLRVLSARDTVPGVIRGRAVRLLLDDGQLAQDEAARLMGLVLSPGTPPGDAAAWIEGFVGGGGGGMLLVHDERLLGLVDGWLTGVPAEAFTDVLPLLRRTFSAYEPGVRRTLGELVRREPGQRGSAAAVGSGIPGFGAGLDAERADAVLPVVRLLLGLDGAGEEDSAELAGVAG
>NZ_CP053109.1|WP_171117587.1|3485550_3486693_-|AAA-family-ATPase
MPVSEEPTFVDQTENTSVQEEAEALRPHAEDAFADELAALAAQDDRPRPARWKLSPWAVATYLLGGTLPDGTVITPKYVGPRRIVEVAVTTLATDRALLLLGVPGTAKTWVSEHLAAAVSGDSTLLVQGTAGTPEEAIRYGWNYAQLLAHGPSRDALVPSPVMRAMAEGMTARVEELTRIPADVQDTLITILSEKTLPIPELGQEVQAVRGFNLIATANDRDRGVNDLSSALRRRFNTVVLPLPDSVEAEVDIVSRRVDQIGRSLDLPAVPDGVDEIRRVVTVFRELRDGITADGRTKVKSPSGTLSTAEAISVVTNGLALAAHFGDGVLRPSDVAAGILGAVVRDPAADRVVWQEYLEAVVRERDGWKDFYRACREVSA
>NZ_CP053109.1|WP_171117586.1|3486826_3488182_+|SWIM-zinc-finger-family-protein
MTQQGVRWTAEQVLALAPDAASRKAGSKLGAAGPWSEAGSSDEGTVWGLCKGSGSRPYQTVIDIADASGPAYKCSCPSRKFPCKHALGLLLLWSGDDGAVPPGQAPDWAEQWIAGRRQRAAEKRTPGTAGSPPAAADPEAARRRAERRAERITAGATELEQRLADLLRGGLAAAEQAGYGLWEETAARMVDAQAPGLAARVRELGAIPASGPGWPVRLLEECALLHLLDQGWLHRDRLPESLAATVRSRVGLPASADGPPVRDRWLVLAQYDTADTRLTTRRIWLYGADSDRTTLLLSYGAAGRAPELALPVGLTLEAEVSAYPGAGQARAALGEQFAPPAPTSIRPPGMTTTQAAVHYGEALRADPWLDSVPATLDRVIPTPDGNSWQLADADEDAALPLTPAARARPGLWRLVALSGGAPVKVFGECGHQGFTPLTAWPQGTDTPVPLC
>NZ_CP053109.1|WP_171119168.1|3488305_3489931_+|hypothetical-protein
MLADHGHAGATAWEDLVTTALLGTDRRTPPPSLSALSAPGREAPMALLDAAAAETVRRRAGLRPARPAPRPDPAPEDSRPPLPAAAARRLALLLADRPGASGGGRRGAAPDLMELLPQWLALANAHHYAAPPETLPALLDAARGRTDLRPAALTFAGPRALWLARLNPDWRFALRATPGGGTTLPHLQDTENVQQLWQEGLFAERVSLLAALRAQDATTARDLLASTWATERAEDRLMFLDSLRTNLTAEDEPFLEQALADRSRNVRATAAELLSALPGSALAARMAVRAGACVALDHTRDTPTITVEAPHECDASMERDGVVAKAPAGRGERSWWFGQLVEAAPLATWQARLGGRRPQEIVALPVADDWQADLHAAWCRAAVRQRNADWSRALLGAPSAPEAGGPGAVSLAERAKLLDTLGADERADWVAGFIATHGLSEAFQLLGVCAVPWSAPLGRAVVDALNIARDAGSYPWSFSGVMGLAERCLDPSEANRLDGLLSIPEEPENASPGAGGYWAEAFQRLVTTLRLRAAMAEELNP
>NZ_CP053109.1|WP_171117585.1|3490228_3490645_-|cobalamin-B12-binding-domain-containing-protein
MGVAAGPIRVVVAKPGLDGHDRGAKVIARALRDAGMEVIYTGLHQTPEQIVDTAIQEDADAIGLSILSGAHNTLFAAVIDLLKERDAEDILVFGGGIIPEGDIAPLKEKGVAEIFTPGATTTSIVEWVRENVRQPAEA
>NZ_CP053109.1|WP_171117584.1|3491341_3492235_+|alpha/beta-fold-hydrolase
MKVTQVTRALLPFHPLHRHLLPIPSSLAGLSLALLKATALEIAILAGHLILYPSGIVQERRTPAPRIPAQEDAAQLPTESKPPVVLLHGFIDNRSVFLLLRRSLAQHGRHQVVSLNYSPLTCDIRAAAKLLGRHIEEICERTDSDQVDIVGHSLGGLIARYYVQRLAGDTRVRTLVTLGTPHSGTRVAPLANAHPIVRQMRPGSAVIEELALPAPGCRTRFVSFWSDLDHLMDPLETACLEHPDLRAQNVRVSGIGHLALPVHPAVASGIRQALEGAYHSSTEGAQSATRNGGLTVA
>NZ_CP053109.1|WP_171117582.1|3492410_3494114_+|M23-family-metallopeptidase
MPVSCARETCRRLSCPRTAGYSRRTALPAPVVEAKEKLVNDRHPSGTMTTPAPASEAASAHYASYGTQEAQYGDFTTYAGYSANGFDTGSHATTTTPTATTTFESDPLFGDLAGSGHGTGAYDASQWSTGSHQTVNYDPYAAQHHAAYDTGAYDTTTWTAEHQQLPLIPQQAGAVDASGQWDASAWLQPEQGGPADQTQQWEWGTQAFDTGAYDATQWNSDGGGHDTGQATEEYEQHTEAYDFAQHAEPFDHQASATFDEQANATFDQQSTATFEQVDLGEDTHGDGEPDTTGETPAATPLLLDDQEQVTSAPTGRAAARNAARSRRRTPAKRSALLTVAVPSACVMGVAGIAAASVGTLSGDDQDTSATAADTLAVKPSAANQQLNTQLESLTAEAQDFGDRVSRTQERIDLKEQQAAEKRRAAEEAARKERLRPKFALPVAQHGLSAYYGQAGINWMSVHTGIDFPVSYGTTVMAATDGTVRTEWNSAYGNMMIVTAMDGTETWYCHLSSYRVASGTTVKAGDPIAYSGNSGNSTGPHLHFEVRPGGGSSIDPLSWLRSHGLDPS
>NZ_CP053109.1|WP_171117580.1|3494172_3496656_-|DNA-helicase-PcrA
MSSLFDDSFLADLQAPRAHEEPPPPPEDDHTPESIPDDLFGGKFDVPPDRDAYYRDGAPRPAMDSAALLEGLNDNQRAAVVHSGSPLLIVAGAGSGKTRVLTHRIAYLLAERGVHPGQILAITFTNKAAGEMKERVEQLVGPRAHAMWVMTFHSACVRILRRESKKLGFTSSFSIYDAADSKRLMALVCRDLDLDPKRFPPKSFSAKISNLKNELIDEEDFAAQAADGFEKTLAQAYALYQSRLREANALDFDDLIMTTVNLLRAFPDVAEHYRRRFRHVLVDEYQDTNHAQYALVRELVGTGERAAEDIDVPPGEDDLAPAELCVVGDADQSIYAFRGATIRNILQFEEDYPDATTILLEQNYRSTQTILSAANAVIERNESRRPKNLWTNAGAGARITGYVADTEHDEAQFVADEIDRLTDAGEAKAGDVAVFYRTNAQSRVFEEIFIRVGLPYKVVGGVRFYERKEVRDVLAYLRVLANPEDSVPLRRILNVPKRGIGDRAEAMIDALSQREKISFPQALKRVDEAYGMAARSTNAVKRFNTLMEDLRTIVDSGAGPATILEAVLERTGYLAELQASTDPQDETRIENLQELAAVALEFEQERGEGEAGTLADFLEQVALVADSDQIPDEEEGEGVITLMTLHTAKGLEFPVVFLTGMEDGVFPHMRALGQTKELEEERRLAYVGITRARERLYLTRSAMRSAWGQPQYNPPSRFLEEIPAAHVDWKRTGASAAPAGRVSGVAASLSSSRSRSSASGASGFATRRTAEQPVVGLAVGDRVTHDQFGLGTVVAVKGTGANAEATIDFGDAKPKRLLLRYAPVEKL
>NZ_CP053109.1|WP_171117578.1|3497107_3498292_+|C40-family-peptidase
MASHRKSRPTGARVAGIRTPALATAALTSVALLSQTANAAPSADDNPSLEEVEKKVDDLYRQAESATEKYNAAKEKTAKQRKRVDALLDDVAQRTQKLNEAREELGTYAAAQYRTGASVPDTATFLLADSPQDYFDQTQLMGRLTSRQKDAVHEYFTEQSATMQKRQEATESLARLTESQSDLQTAKATVQKKLADARELLSKLTAEEKARLAAIEKQKQEEAERKAAELARQQAEEQRRQEAAQQQEQESAGGGASAGTGNESGSGTSVSDSAYATKAEKALAFARAQIGKPYVWGATGPDSYDCSGLTQAAWKAAGVSLPRTTYDQVDAGTTVSIAAAQPGDLIFFYDDVTHVGLYIGNGMMIHAPKPGTYVREESVYYDGESSIHSVVRPA

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Crispr_ID: NZ_CP053109_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053109_4

3479235-3479441

Orphan

Consensus_repeat	Method
ACCGGCGTCACCCCGGCGACCGCC	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP053109_4

>merge|NZ_CP053109|4|3479235-3479441|CRISPRCasFinder
ACCGGCGTCACCCCGGCGACCGCCCCGGTGACGGCCGGCGTCACACCCTGCACGGCGTGGCCGGCGACCGGCGTCACCCCGGCCACCGCCGCACCGGCGACGGGCACCGCCCCAGCCACGGCCCCCTGGGCAACCGGCCCCACTCCGCCCACGGCAGTCCCGACCACGGGCGGCACCACAGCGGCTCCCGTCTCCGCGGCAACCGCC

>NZ_CP053109|4|2|3479235-3479441|CRISPRCasFinder
ACCGGCGTCACCCCGGCGACCGCC	CCGGTGACGGCCGGCGTCACACCCTGCACGGCGTGGCCGGCG
ACCGGCGTCACCCCGGCCACCGCC	GCACCGGCGACGGGCACCGCCCCAGCCACGGCCCCCTGGGCA
ACCGGCCCCACTCCGCCCACGGCA	GTCCCGACCACGGGCGGCACCACAGCG
GCTCCCGTCTCCGCGGCAACCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053109.1\|WP_171117600.1\|3466286_3468179_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP053109.1\|WP_171117602.1\|3465328_3465787_+\|peptidoglycan-binding-protein	unknown	unknown	gnl\|CDD\|366659
NZ_CP053109.1\|WP_171117587.1\|3485550_3486693_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|336785
NZ_CP053109.1\|WP_141312482.1\|3475348_3476233_-\|succinate--CoA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|180194
NZ_CP053109.1\|WP_171119168.1\|3488305_3489931_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171117604.1\|3464710_3465271_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366659
NZ_CP053109.1\|WP_171117590.1\|3476261_3477443_-\|ADP-forming-succinate--CoA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234813
NZ_CP053109.1\|WP_171117585.1\|3490228_3490645_-\|cobalamin-B12-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|239022
NZ_CP053109.1\|WP_171117582.1\|3492410_3494114_+\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NZ_CP053109.1\|WP_171117596.1\|3468579_3470145_-\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234854
NZ_CP053109.1\|WP_171117598.1\|3468192_3468438_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235300
NZ_CP053109.1\|WP_171117580.1\|3494172_3496656_-\|DNA-helicase-PcrA	unknown	unknown	gnl\|CDD\|273429
NZ_CP053109.1\|WP_171117591.1\|3474022_3475177_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|132028
NZ_CP053109.1\|WP_171117586.1\|3486826_3488182_+\|SWIM-zinc-finger-family-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171117578.1\|3497107_3498292_+\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NZ_CP053109.1\|WP_171117584.1\|3491341_3492235_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|224001
NZ_CP053109.1\|WP_171117589.1\|3481811_3482993_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|283431
NZ_CP053109.1\|WP_171117588.1\|3483033_3485460_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171117593.1\|3471126_3471921_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171117595.1\|3470141_3470780_-\|phosphoribosylglycinamide-formyltransferase	unknown	unknown	gnl\|CDD\|235544

Protein	Function_ID	Function_description	E-value
NZ_CP053109.1\|WP_171117600.1\|3466286_3468179_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	5.61085e-73
NZ_CP053109.1\|WP_171117602.1\|3465328_3465787_+\|peptidoglycan-binding-protein	gnl\|CDD\|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	8.97726e-09
NZ_CP053109.1\|WP_171117587.1\|3485550_3486693_-\|AAA-family-ATPase	gnl\|CDD\|336785	pfam07728, AAA_5, AAA domain (dynein-related subfamily). This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.	1.72885e-41
NZ_CP053109.1\|WP_141312482.1\|3475348_3476233_-\|succinate--CoA-ligase-subunit-alpha	gnl\|CDD\|180194	PRK05678, PRK05678, succinyl-CoA synthetase subunit alpha; Validated.	0
NZ_CP053109.1\|WP_171117580.1\|3494172_3496656_-\|DNA-helicase-PcrA	gnl\|CDD\|273429	TIGR01073, ATP-dependent_DNA_helicase_PcrA, ATP-dependent DNA helicase PcrA. Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP053109.1\|WP_171117604.1\|3464710_3465271_+\|hypothetical-protein	gnl\|CDD\|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	0.00526739
NZ_CP053109.1\|WP_171117590.1\|3476261_3477443_-\|ADP-forming-succinate--CoA-ligase-subunit-beta	gnl\|CDD\|234813	PRK00696, sucC, ADP-forming succinate--CoA ligase subunit beta.	0
NZ_CP053109.1\|WP_171117585.1\|3490228_3490645_-\|cobalamin-B12-binding-domain-containing-protein	gnl\|CDD\|239022	cd02071, MM_CoA_mut_B12_BD, methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom with a group attached to a neighboring carbon atom. This family is present in both mammals and bacteria. Bacterial members are heterodimers and involved in the fermentation of pyruvate to propionate. Mammalian members are homodimers and responsible for the conversion of odd-chain fatty acids and branched-chain amino acids via propionyl CoA to succinyl CoA for further degradation.	3.65919e-64
NZ_CP053109.1\|WP_171117582.1\|3492410_3494114_+\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	5.49042e-37
NZ_CP053109.1\|WP_171117596.1\|3468579_3470145_-\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	gnl\|CDD\|234854	PRK00881, purH, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional.	0
NZ_CP053109.1\|WP_171117598.1\|3468192_3468438_-\|hypothetical-protein	gnl\|CDD\|235300	PRK04447, PRK04447, hypothetical protein; Provisional.	0.00569634
NZ_CP053109.1\|WP_171117591.1\|3474022_3475177_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	8.6353e-11
NZ_CP053109.1\|WP_171117578.1\|3497107_3498292_+\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	5.3694e-34
NZ_CP053109.1\|WP_171117584.1\|3491341_3492235_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|224001	COG1075, LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only].	6.843e-18
NZ_CP053109.1\|WP_171117589.1\|3481811_3482993_-\|VWA-domain-containing-protein	gnl\|CDD\|283431	pfam05762, VWA_CoxE, VWA domain containing CoxE-like protein. This family is annotated by SMART as containing a VWA (von Willebrand factor type A) domain. The exact function of this family is unknown. It is found as part of a CO oxidising (Cox) system operon is several bacteria.	3.92829e-52
NZ_CP053109.1\|WP_171117595.1\|3470141_3470780_-\|phosphoribosylglycinamide-formyltransferase	gnl\|CDD\|235544	PRK05647, purN, phosphoribosylglycinamide formyltransferase; Reviewed.	1.6394e-111

>NZ_CP053109.1|WP_171117590.1|3476261_3477443_-|ADP-forming-succinate--CoA-ligase-subunit-beta
MDLFEYQARDLFAKHDVPVLAGEVIDTPEAAREITERLGGKSVVKAQVKVGGRGKAGGVKLAATPDEAVARATDILGMDIKGHTVHKVMIAETAPEILEEYYVSFLLDRANRTFLSIASVEGGVEIEEVAATRPEAVAKIAIDPIDGVDEAKAREIVEAAKFPAEVADKVVNVLVKLWDTFIKSDALLVEVNPLAKVASGDVIALDGKVSLDDNAEFRHPEYEELHDKAAANPLEAAAKEKNLNYVKLDGEVGIIGNGAGLVMSTLDVVAYAGEKHGNVKPANFLDIGGGASAQVMANGLEIILGDPDVKSVFVNVFGGITACDEVANGIVQALKLLEDRGENVTKPLVVRLDGNNAELGRQILTDANHPLVQRVDTMDGAADKAAELAAAAK
>NZ_CP053109.1|WP_141312482.1|3475348_3476233_-|succinate--CoA-ligase-subunit-alpha
MAIWLNKDSKVIVQGMTGATGMKHTKLMLGDGTHVVGGVNPRKAGQSVDFDGTEVPVFGTVKEAIEKTGANVSVIFVPEKFTKDAVVEAIDAEIPLAVVITEGIAVHDSASFWAYAGKKGNKTRIIGPNCPGIITPGQSNVGIIPGDITKPGRIGLVSKSGTLTYQMMYELRDIGFSTAVGIGGDPIIGTTHIDALAAFQADPDTDLIVMIGEIGGDAEERAAAFIKENVTKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAQAKKEALEAAGVKVGKTPTETAKLAREILAG
>NZ_CP053109.1|WP_171117591.1|3474022_3475177_+|helix-turn-helix-domain-containing-protein
MTESPVTPLPPPEERRRLREAGALTRAQVASRVGVSKATVRAWESGRTTPDGRKAEAYATLLASLATEAAATAVRTEEQPASGPEPSPESSPGSLPGSPPDSSPVSLPESSPERESGLEPLTPAQAFDALYAFCAPDLVRQAYVLTGRRELARESVERAFQLAWQRWPEVAVDPDPAGWVRLAAYEYALSPWHRFRPRYRHPEPPPADQRDRALLSALLELPPPYRRTLLLYDGVGLDLPETAAETEASTPATANRLMHARQAVASCLPDLADPEELQRRLTDLASTERLRAARPVAVRRGGERRAQFWTRAAIAFTVTLIGATALTLRTAPTQYEPPVPPGETVRGVPPRAAPGPLSYEQLMLREKLRQAMASGEERLVPEAR
>NZ_CP053109.1|WP_171117593.1|3471126_3471921_+|hypothetical-protein
MPDRSLRLLTFPPQSVQGRERSGVLLRERPASPADAPSGDANGDRQDDNPFAPPPEGTPDRPWQPRRPSGDSGDSAGSTGSTGSEGSQGDGGRPAWGSQWSDRQPGRSSGGGFGDRPGGGPERPGGPAPGMRWDPTDPAQRRARYALLAGMWAFFFALFTWTYVALLLGALALYWGISALRTKPRTPSPDTPAGATPARPQAAAAVSGLVTASLAIALVGASFAAQLVYRDYYTCTNDALTNEARQDCSKLLPEQLRDVLGANS
>NZ_CP053109.1|WP_171117595.1|3470141_3470780_-|phosphoribosylglycinamide-formyltransferase
MAAKPVAKRAKRLVVLVSGSGTNLQALLDAIAAEGAEAYGAEIVAVGADRDGIEGLARAERAGLPTFVRKVKDYESREAWDAALAEAVAAYEPDLVVSAGFMKIVGKEFLARYGGRFINTHPALLPSFPGAHGVRDALAYGARVTGCTVHFVDDGVDTGPIIAQGVVEVRDEDDESALHERIKEVERRLLVDVVGRLARNGYRIEGRKVVIQ
>NZ_CP053109.1|WP_171117596.1|3468579_3470145_-|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase
MTATAESNKRAIRRALVSVYDKTGLEELARGLHEAGVELVSTGSTAARIAAAGVPVTKVEELTGFPECLDGRVKTLHPKVHAGILADLRLDSHRQQLDELGVAPFDLVVVNLYPFEETVASGASPDECVEQIDIGGPSMVRAAAKNHPSVAVVTSPERYADVLAAVRDGGFDLAARKRLAAEAFRHTAEYDVAVAGWFAGEYAGEGAEFPEFIGVTYQRKQVLRYGENPHQPAALYTGGCGGLAEAEQLHGKEMSYNNYTDTDAARRAAYDHDEPCVAIIKHANPCGIAIGADVAEAHRKAHACDPLSAFGGVIAVNRPVSKEMAEQVAEIFTEVIVAPDYEEGALEALAKKKNIRVLRCPQAPETSAEFKPIDGGGLAQITDVFQAEGDDPANWTLATGEALSPEELKELAFAWRACRAVKSNAILLAKDGASVGVGMGQVNRVDSAKLAVERAGAERAQGSYAASDAFFPFPDGLEILTEAGVKAVVQPGGSVRDEQVVEAARKAGVTMYFTGTRHFFH
>NZ_CP053109.1|WP_171117598.1|3468192_3468438_-|hypothetical-protein
MLSCACFNPVDIMVAWTGYGLLGVAGLIIGFVCLVGMLLAGMAVVGHVIRRWQGDDHVPGAGGTDEERLGLASFRWESEPD
>NZ_CP053109.1|WP_171117600.1|3466286_3468179_+|protein-kinase
MTDQRPGSPYTPAAGDAALRQAGAKPLEAADPGRIGPYVPLGLLGSGGMGRVYLARPADDSPGLAAVKVIRPEYAEDPEFRRRFEREAAVQARVHTPHAPQLLGTGFDDSLLWMATQYLPGLNLADAVRECGGLGSAGLWRLVAELGQALSALAAAGVVHRDLKPSNVILSLRHAHVIDFGISQAADASSITTTGSRVGTPAFMSPEYLREGRCDTASDVFSLAGTLIYAATGTAPFGDGTGVDVMHRVAFEEPKAEIMAELTVVDPELAAFLSACLAKDPAGRPTPRQLIDAAAAAGHGHAPSWQEPLGGHLLSRQQACEVLERASARQTGHFRAPTEPVASPAPRPAFGPATPPSPYGAPPTPPGPYGTPSTPPAAYGMATPPAHYGTSPQGPPSVGNGASGTRRSGRKPYLAVAAGVAVVAVIVSAFLLTRPEFDETASASPTTSGSTASDNEPGSVSPSPSSSPSSREKEKEKEEGKEKEKGESEGQGEDEQATGGAADGSGGSSGGGTGGAQPTVTVTATSGSGTAGGTGTSPTETATTPAEPPWNTQCTYYSGTALTRYGDKNSRVTQVQCMLVKRGYSVGNAGVDGQFGDGTRAAVKKFQSAKGLDVDGIVGANTWGALRSST
>NZ_CP053109.1|WP_171117602.1|3465328_3465787_+|peptidoglycan-binding-protein
MVRGSSPHIRVGLVTGALTATLLGGALAVAPAASAASYPTCNAVKRVYLSSTVWVRQPYYSGTGSRNCILQYGNSSSAVTALQDALITCYRQDTGGKDGIYGPKTRQAVYNVQTQYRDIANDGIYGPETRKKMGWRVYNNGNATTQCTAPGV
>NZ_CP053109.1|WP_171117604.1|3464710_3465271_+|hypothetical-protein
MNIAMPRIRLTTAVVAATVAAGMLTVSAQPASANVSEGYVKGAYMYQDDFGDEGTLSTGSHAHTNATALWQWILWAEGAKKSNGDAFAHGDIDCWFGSDTKSATISLQRTLKLKSIDGIVGNETFGAVDGNIEWVSSNNDSYPYRTKLRYKGNEHAFFLYRSASGVYKVYIPNVGWKPASYTYANC
>NZ_CP053109.1|WP_171117589.1|3481811_3482993_-|VWA-domain-containing-protein
MTAEAMGVAELDDAGRERLRRWRLVLGSDAADGTGCALGGRDAAMDGALAALYGQGDKPQTGRERAAGLGASAPSVARWLGDIRTYFPSSVVQVMQRDAIDRLGLSALLLEPEMLEAVEADVHLVGTLLSLNKAMPETTKETARAVVRKVVEDLEKRLATRTRATLSGALDRSARINRPRHHDIDWNRTIAANLKHYLPEYRTVVPERLIGYGRASQSVKKEVILCIDQSGSMAASVVYASVFGAVLASMRTISTRLVVFDTAVVDLTDQLEDPVDVLFGTQLGGGTDINRALAYCQSQITRPAETVVVLISDLYEGGIRNEMLKRVAAMKGAGVQFVTLLALSDEGAPAYDREHAAALAALGAPAFACTPDLFPEVMAAAIEKRPLPIPDTA
>NZ_CP053109.1|WP_171117588.1|3483033_3485460_-|hypothetical-protein
MTGVERAGSSGLTGTEPLLFGVRHHGPGSARAVRAALDAARPRVLLIEGPPEADALIPLAGDEDMRPPVALLVHAVDEPGRSAFWPLAEFSPEWVAIRWALEQGVPARFIDLPATHTLVWGSEAEGESAGDGGGVGGGEAGPDADADAGADAGTDAAPQSDVRVDPLGVLAEAAGYDDAERWWEDVVEHRGLGEGDAFAPFAVVEEAMGALREVYGSGGHDRDLVREAYMRLQVRTAQREFGGGVAVVCGAWHVPALRQKVTVAADRALLKGLPKVKVDMTWVPWTHRRLARASGYGAGIDSPGWYGHLFSAPDRPVERWMTKVAGLLRAEDRTVSSAHVIEAVRLAETLAAMRGRPLAGLGETTDAIRAVMCEGSDVPLALVHDRLIVGDVLGEVPDAAPAVPLQRDLARLQRRLRLKPEALERELELDLRKEADAGRSRLLHRLRLLGVVWGEQVVSRGSTGTFRETWRLRWEPELSVRVAEAGVWGTTVLAAATAKAEADAMAAQGLADVTALAERCLLAELPDALPAVMRILADRAALDADVGHLAQALPALVRSLRYGDVRGTDTGALGEVAAGLAERIFVGLPPACAALDTDAAEEMRRHVDAVHTAVGLLGEAPAAGHGDLRGRWHSVLRVLSARDTVPGVIRGRAVRLLLDDGQLAQDEAARLMGLVLSPGTPPGDAAAWIEGFVGGGGGGMLLVHDERLLGLVDGWLTGVPAEAFTDVLPLLRRTFSAYEPGVRRTLGELVRREPGQRGSAAAVGSGIPGFGAGLDAERADAVLPVVRLLLGLDGAGEEDSAELAGVAG
>NZ_CP053109.1|WP_171117587.1|3485550_3486693_-|AAA-family-ATPase
MPVSEEPTFVDQTENTSVQEEAEALRPHAEDAFADELAALAAQDDRPRPARWKLSPWAVATYLLGGTLPDGTVITPKYVGPRRIVEVAVTTLATDRALLLLGVPGTAKTWVSEHLAAAVSGDSTLLVQGTAGTPEEAIRYGWNYAQLLAHGPSRDALVPSPVMRAMAEGMTARVEELTRIPADVQDTLITILSEKTLPIPELGQEVQAVRGFNLIATANDRDRGVNDLSSALRRRFNTVVLPLPDSVEAEVDIVSRRVDQIGRSLDLPAVPDGVDEIRRVVTVFRELRDGITADGRTKVKSPSGTLSTAEAISVVTNGLALAAHFGDGVLRPSDVAAGILGAVVRDPAADRVVWQEYLEAVVRERDGWKDFYRACREVSA
>NZ_CP053109.1|WP_171117586.1|3486826_3488182_+|SWIM-zinc-finger-family-protein
MTQQGVRWTAEQVLALAPDAASRKAGSKLGAAGPWSEAGSSDEGTVWGLCKGSGSRPYQTVIDIADASGPAYKCSCPSRKFPCKHALGLLLLWSGDDGAVPPGQAPDWAEQWIAGRRQRAAEKRTPGTAGSPPAAADPEAARRRAERRAERITAGATELEQRLADLLRGGLAAAEQAGYGLWEETAARMVDAQAPGLAARVRELGAIPASGPGWPVRLLEECALLHLLDQGWLHRDRLPESLAATVRSRVGLPASADGPPVRDRWLVLAQYDTADTRLTTRRIWLYGADSDRTTLLLSYGAAGRAPELALPVGLTLEAEVSAYPGAGQARAALGEQFAPPAPTSIRPPGMTTTQAAVHYGEALRADPWLDSVPATLDRVIPTPDGNSWQLADADEDAALPLTPAARARPGLWRLVALSGGAPVKVFGECGHQGFTPLTAWPQGTDTPVPLC
>NZ_CP053109.1|WP_171119168.1|3488305_3489931_+|hypothetical-protein
MLADHGHAGATAWEDLVTTALLGTDRRTPPPSLSALSAPGREAPMALLDAAAAETVRRRAGLRPARPAPRPDPAPEDSRPPLPAAAARRLALLLADRPGASGGGRRGAAPDLMELLPQWLALANAHHYAAPPETLPALLDAARGRTDLRPAALTFAGPRALWLARLNPDWRFALRATPGGGTTLPHLQDTENVQQLWQEGLFAERVSLLAALRAQDATTARDLLASTWATERAEDRLMFLDSLRTNLTAEDEPFLEQALADRSRNVRATAAELLSALPGSALAARMAVRAGACVALDHTRDTPTITVEAPHECDASMERDGVVAKAPAGRGERSWWFGQLVEAAPLATWQARLGGRRPQEIVALPVADDWQADLHAAWCRAAVRQRNADWSRALLGAPSAPEAGGPGAVSLAERAKLLDTLGADERADWVAGFIATHGLSEAFQLLGVCAVPWSAPLGRAVVDALNIARDAGSYPWSFSGVMGLAERCLDPSEANRLDGLLSIPEEPENASPGAGGYWAEAFQRLVTTLRLRAAMAEELNP
>NZ_CP053109.1|WP_171117585.1|3490228_3490645_-|cobalamin-B12-binding-domain-containing-protein
MGVAAGPIRVVVAKPGLDGHDRGAKVIARALRDAGMEVIYTGLHQTPEQIVDTAIQEDADAIGLSILSGAHNTLFAAVIDLLKERDAEDILVFGGGIIPEGDIAPLKEKGVAEIFTPGATTTSIVEWVRENVRQPAEA
>NZ_CP053109.1|WP_171117584.1|3491341_3492235_+|alpha/beta-fold-hydrolase
MKVTQVTRALLPFHPLHRHLLPIPSSLAGLSLALLKATALEIAILAGHLILYPSGIVQERRTPAPRIPAQEDAAQLPTESKPPVVLLHGFIDNRSVFLLLRRSLAQHGRHQVVSLNYSPLTCDIRAAAKLLGRHIEEICERTDSDQVDIVGHSLGGLIARYYVQRLAGDTRVRTLVTLGTPHSGTRVAPLANAHPIVRQMRPGSAVIEELALPAPGCRTRFVSFWSDLDHLMDPLETACLEHPDLRAQNVRVSGIGHLALPVHPAVASGIRQALEGAYHSSTEGAQSATRNGGLTVA
>NZ_CP053109.1|WP_171117582.1|3492410_3494114_+|M23-family-metallopeptidase
MPVSCARETCRRLSCPRTAGYSRRTALPAPVVEAKEKLVNDRHPSGTMTTPAPASEAASAHYASYGTQEAQYGDFTTYAGYSANGFDTGSHATTTTPTATTTFESDPLFGDLAGSGHGTGAYDASQWSTGSHQTVNYDPYAAQHHAAYDTGAYDTTTWTAEHQQLPLIPQQAGAVDASGQWDASAWLQPEQGGPADQTQQWEWGTQAFDTGAYDATQWNSDGGGHDTGQATEEYEQHTEAYDFAQHAEPFDHQASATFDEQANATFDQQSTATFEQVDLGEDTHGDGEPDTTGETPAATPLLLDDQEQVTSAPTGRAAARNAARSRRRTPAKRSALLTVAVPSACVMGVAGIAAASVGTLSGDDQDTSATAADTLAVKPSAANQQLNTQLESLTAEAQDFGDRVSRTQERIDLKEQQAAEKRRAAEEAARKERLRPKFALPVAQHGLSAYYGQAGINWMSVHTGIDFPVSYGTTVMAATDGTVRTEWNSAYGNMMIVTAMDGTETWYCHLSSYRVASGTTVKAGDPIAYSGNSGNSTGPHLHFEVRPGGGSSIDPLSWLRSHGLDPS
>NZ_CP053109.1|WP_171117580.1|3494172_3496656_-|DNA-helicase-PcrA
MSSLFDDSFLADLQAPRAHEEPPPPPEDDHTPESIPDDLFGGKFDVPPDRDAYYRDGAPRPAMDSAALLEGLNDNQRAAVVHSGSPLLIVAGAGSGKTRVLTHRIAYLLAERGVHPGQILAITFTNKAAGEMKERVEQLVGPRAHAMWVMTFHSACVRILRRESKKLGFTSSFSIYDAADSKRLMALVCRDLDLDPKRFPPKSFSAKISNLKNELIDEEDFAAQAADGFEKTLAQAYALYQSRLREANALDFDDLIMTTVNLLRAFPDVAEHYRRRFRHVLVDEYQDTNHAQYALVRELVGTGERAAEDIDVPPGEDDLAPAELCVVGDADQSIYAFRGATIRNILQFEEDYPDATTILLEQNYRSTQTILSAANAVIERNESRRPKNLWTNAGAGARITGYVADTEHDEAQFVADEIDRLTDAGEAKAGDVAVFYRTNAQSRVFEEIFIRVGLPYKVVGGVRFYERKEVRDVLAYLRVLANPEDSVPLRRILNVPKRGIGDRAEAMIDALSQREKISFPQALKRVDEAYGMAARSTNAVKRFNTLMEDLRTIVDSGAGPATILEAVLERTGYLAELQASTDPQDETRIENLQELAAVALEFEQERGEGEAGTLADFLEQVALVADSDQIPDEEEGEGVITLMTLHTAKGLEFPVVFLTGMEDGVFPHMRALGQTKELEEERRLAYVGITRARERLYLTRSAMRSAWGQPQYNPPSRFLEEIPAAHVDWKRTGASAAPAGRVSGVAASLSSSRSRSSASGASGFATRRTAEQPVVGLAVGDRVTHDQFGLGTVVAVKGTGANAEATIDFGDAKPKRLLLRYAPVEKL
>NZ_CP053109.1|WP_171117578.1|3497107_3498292_+|C40-family-peptidase
MASHRKSRPTGARVAGIRTPALATAALTSVALLSQTANAAPSADDNPSLEEVEKKVDDLYRQAESATEKYNAAKEKTAKQRKRVDALLDDVAQRTQKLNEAREELGTYAAAQYRTGASVPDTATFLLADSPQDYFDQTQLMGRLTSRQKDAVHEYFTEQSATMQKRQEATESLARLTESQSDLQTAKATVQKKLADARELLSKLTAEEKARLAAIEKQKQEEAERKAAELARQQAEEQRRQEAAQQQEQESAGGGASAGTGNESGSGTSVSDSAYATKAEKALAFARAQIGKPYVWGATGPDSYDCSGLTQAAWKAAGVSLPRTTYDQVDAGTTVSIAAAQPGDLIFFYDDVTHVGLYIGNGMMIHAPKPGTYVREESVYYDGESSIHSVVRPA

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Crispr_ID: NZ_CP053109_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053109_5

3943366-3943609

Orphan

Consensus_repeat	Method
AGGCGGGGAACCGGAGCAGGTAGTGGAGGCGAGCGCGCAGCCAGCCAA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP053109_5

>merge|NZ_CP053109|5|3943366-3943609|CRISPRCasFinder
TCAAGGCCGGGCGGACCAGCCAGCGGAGGCGAGCGCGCAGCCAGCCAGCCAAGGCCGTGCGGAGGCAGCCAGCCGAGGCGGGGACGGGAGCGGGCAGTGGAGGCGGGGAACCGGAGCAGGTAGTGGAGGCGAGCGCGCAGCCAGCCAACCATAACGAGGGCAGACCAGCTAGCCGAGCCGAGGACGGAACCAGCCCAGGCGGGGAACCGGAGCAGGCAGTGGAGGCGAGCGCGCAGCCAGCCAA

>NZ_CP053109|5|3|3943366-3943609|CRISPRCasFinder
TCAAGGCCGGGCGGACCAGCCAGCGGAGGCGAGCGCGCAGCCAGCCAG	CCAAGGCCGTGCGGAGGCAGCCAGCCGAGGCGGGGACGGGAGCGGGCAGTGG
AGGCGGGGAACCGGAGCAGGTAGTGGAGGCGAGCGCGCAGCCAGCCAA	CCATAACGAGGGCAGACCAGCTAGCCGAGCCGAGGACGGAACCAGCCC
AGGCGGGGAACCGGAGCAGGCAGTGGAGGCGAGCGCGCAGCCAGCCAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053109.1\|WP_003999141.1\|3941204_3941369_-\|50S-ribosomal-protein-L33	unknown	unknown	gnl\|CDD\|179075
NZ_CP053109.1\|WP_171111589.1\|3942178_3942676_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171109670.1\|3957442_3958648_-\|DNA-polymerase-III-subunit-delta'	unknown	unknown	gnl\|CDD\|236134
NZ_CP053109.1\|WP_171109671.1\|3955580_3957188_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|312032
NZ_CP053109.1\|WP_171109682.1\|3938869_3939169_-\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
NZ_CP053109.1\|WP_171109672.1\|3953751_3954249_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171111587.1\|3947949_3951582_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276938
NZ_CP053109.1\|WP_171134039.1\|3939764_3940943_-\|GTP-binding-protein	unknown	unknown	gnl\|CDD\|214844
NZ_CP053109.1\|WP_171109683.1\|3938246_3938759_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP053109.1\|WP_171109679.1\|3941667_3941973_+\|30S-ribosomal-protein-S14	unknown	unknown	gnl\|CDD\|181574
NZ_CP053109.1\|WP_171109681.1\|3939524_3939758_-\|30S-ribosomal-protein-S18	unknown	unknown	gnl\|CDD\|184031
NZ_CP053109.1\|WP_171109674.1\|3952090_3953050_+\|D-2-hydroxyacid-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|240646
NZ_CP053109.1\|WP_171109669.1\|3958809_3962046_-\|dTMP-kinase	unknown	unknown	gnl\|CDD\|234814
NZ_CP053109.1\|WP_171109677.1\|3944148_3945345_-\|DUF2786-domain-containing-protein	unknown	unknown	gnl\|CDD\|378525
NZ_CP053109.1\|WP_141315687.1\|3941431_3941668_+\|50S-ribosomal-protein-L28	unknown	unknown	gnl\|CDD\|234736
NZ_CP053109.1\|WP_171109675.1\|3946227_3947922_+\|bifunctional-3'-5'-exonuclease/DNA-polymerase	unknown	unknown	gnl\|CDD\|237876
NZ_CP053109.1\|WP_171109676.1\|3945445_3946192_+\|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|214361
NZ_CP053109.1\|WP_171109678.1\|3942767_3943286_+\|DUF4232-domain-containing-protein	unknown	unknown	gnl\|CDD\|379419
NZ_CP053109.1\|WP_171109680.1\|3940946_3941195_-\|type-B-50S-ribosomal-protein-L31	unknown	unknown	gnl\|CDD\|234969
NZ_CP053109.1\|WP_171109673.1\|3953063_3953738_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP053109.1\|WP_003999141.1\|3941204_3941369_-\|50S-ribosomal-protein-L33	gnl\|CDD\|179075	PRK00595, rpmG, 50S ribosomal protein L33; Validated.	1.21458e-21
NZ_CP053109.1\|WP_171109670.1\|3957442_3958648_-\|DNA-polymerase-III-subunit-delta'	gnl\|CDD\|236134	PRK07940, PRK07940, DNA polymerase III subunit delta'; Validated.	0
NZ_CP053109.1\|WP_171109671.1\|3955580_3957188_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|312032	pfam08386, Abhydrolase_4, TAP-like protein. This is a family of putative bacterial peptidases and hydrolases that bear similarity to a tripeptidyl aminopeptidase isolated from Streptomyces lividans. A member of this family is thought to be involved in the C-terminal processing of propionicin F, a bacteriocidin characterized from Propionibacterium freudenreichii.	7.09147e-35
NZ_CP053109.1\|WP_171109682.1\|3938869_3939169_-\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	1.95171e-17
NZ_CP053109.1\|WP_171111587.1\|3947949_3951582_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	2.97134e-39
NZ_CP053109.1\|WP_171134039.1\|3939764_3940943_-\|GTP-binding-protein	gnl\|CDD\|214844	smart00833, CobW_C, Cobalamin synthesis protein cobW C-terminal domain. CobW proteins are generally found proximal to the trimeric cobaltochelatase subunit CobN, which is essential for vitamin B12 (cobalamin) biosynthesis. They contain a P-loop nucleotide-binding loop in the N-terminal domain and a histidine-rich region in the C-terminal portion suggesting a role in metal binding, possibly as an intermediary between the cobalt transport and chelation systems. CobW might be involved in cobalt reduction leading to cobalt(I) corrinoids. This entry represents the C-terminal domain found in CobW, as well as in P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression.	5.85217e-22
NZ_CP053109.1\|WP_171109683.1\|3938246_3938759_+\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	2.7332e-20
NZ_CP053109.1\|WP_171109676.1\|3945445_3946192_+\|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl\|CDD\|214361	CHL00095, clpC, Clp protease ATP binding subunit.	9.4113e-17
NZ_CP053109.1\|WP_171109681.1\|3939524_3939758_-\|30S-ribosomal-protein-S18	gnl\|CDD\|184031	PRK13401, PRK13401, 30S ribosomal protein S18; Provisional.	5.16314e-32
NZ_CP053109.1\|WP_171109674.1\|3952090_3953050_+\|D-2-hydroxyacid-dehydrogenase-family-protein	gnl\|CDD\|240646	cd12169, PGDH_like_1, Putative D-3-Phosphoglycerate Dehydrogenases. Phosphoglycerate dehydrogenases (PGDHs) catalyze the initial step in the biosynthesis of L-serine from D-3-phosphoglycerate. PGDHs come in 3 distinct structural forms, with this first group being related to 2-hydroxy acid dehydrogenases, sharing structural similarity to formate and glycerate dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily, which also include groups such as L-alanine dehydrogenase and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. Many, not all, members of this family are dimeric.	1.6004e-169
NZ_CP053109.1\|WP_171109680.1\|3940946_3941195_-\|type-B-50S-ribosomal-protein-L31	gnl\|CDD\|234969	PRK01678, rpmE2, type B 50S ribosomal protein L31.	2.60781e-51
NZ_CP053109.1\|WP_171109677.1\|3944148_3945345_-\|DUF2786-domain-containing-protein	gnl\|CDD\|378525	pfam10979, DUF2786, Protein of unknown function (DUF2786). This family of proteins has no known function.	1.88709e-12
NZ_CP053109.1\|WP_171109675.1\|3946227_3947922_+\|bifunctional-3'-5'-exonuclease/DNA-polymerase	gnl\|CDD\|237876	PRK14975, PRK14975, bifunctional 3'-5' exonuclease/DNA polymerase; Provisional.	0
NZ_CP053109.1\|WP_171109669.1\|3958809_3962046_-\|dTMP-kinase	gnl\|CDD\|234814	PRK00698, tmk, thymidylate kinase; Validated.	1.34158e-80
NZ_CP053109.1\|WP_171109679.1\|3941667_3941973_+\|30S-ribosomal-protein-S14	gnl\|CDD\|181574	PRK08881, rpsN, 30S ribosomal protein S14; Reviewed.	3.68367e-49
NZ_CP053109.1\|WP_171109678.1\|3942767_3943286_+\|DUF4232-domain-containing-protein	gnl\|CDD\|379419	pfam14016, DUF4232, Protein of unknown function (DUF4232). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 177 and 242 amino acids in length. Many members of this family are lipoproteins.	1.7901e-11
NZ_CP053109.1\|WP_141315687.1\|3941431_3941668_+\|50S-ribosomal-protein-L28	gnl\|CDD\|234736	PRK00359, rpmB, 50S ribosomal protein L28; Reviewed.	2.28462e-31

>NZ_CP053109.1|WP_171109678.1|3942767_3943286_+|DUF4232-domain-containing-protein
MRATSLTVGSAALAAALLLTACGGGEGDSGGQDTSACALDEVGVEVGPANAAPVAGDTGNIPVTVTNQGAECTLDGFPAVDLHADGTSATVPTDKAATAQKLTLAKDTAATFTITYVRGEAGGDGGLDATTVKIGLPGGSATQSFEWSYGPVALAAGGAPDASVGAFQQAGD
>NZ_CP053109.1|WP_171111589.1|3942178_3942676_+|hypothetical-protein
MAVAAGVVGAVVLTGCSGGGGSDSGSESESGGASASSSPSPSPGTSSVGTGGGGGSPSAAAGELEGSWLATSEGQAVALVVTGEQAGLFATGGTVCSGRVGEASDRQTIRLTCTQGKDKRGTGTVDSVSSTTLKVTWDGGLGEETYTKAEGGQMPSGLPTAGLGS
>NZ_CP053109.1|WP_171109679.1|3941667_3941973_+|30S-ribosomal-protein-S14
MAKKSKIAKNEKRQEIVARYAARRAELKEIVRRPSSTDAERLAAQRELRKQPRDASATRVRNRDQVDGRPRGYFRAFGLSRVGLREQAHAGYLPGVRKSSW
>NZ_CP053109.1|WP_141315687.1|3941431_3941668_+|50S-ribosomal-protein-L28
MSAHCMLTGAQPGFGNRISHSHRRTSRRFDPNIQTKRYWLPSEGRYVRLRLSTKGIKTVDVIGVEAAVARIRARGVKV
>NZ_CP053109.1|WP_003999141.1|3941204_3941369_-|50S-ribosomal-protein-L33
MARNELRPVIKLRSTAGTGYTYVTRKNRRNDPDRMTLRKYDPVVGRHVDFREER
>NZ_CP053109.1|WP_171109680.1|3940946_3941195_-|type-B-50S-ribosomal-protein-L31
MRKGIHPDYGPVVFRDRAANYAFLTRSTMTSDKTIEWEDGNTYPVIDVEISNVSHPFYTGTARVLDTAGRVERFERRYGKQG
>NZ_CP053109.1|WP_171134039.1|3939764_3940943_-|GTP-binding-protein
MPELSVVIVGGLHADARKAAVEQLLADVPGSVVLHHDLATAAAGTVVRTVRDADGLRDAGEAPLVNDCACCALREDLVPELERLADAGDTPLAVVELWDSVEPKAMAEVVTSGGLTVTGVITAVDPALLLPYLGNGDDLAEGGLAAAATDQRTVADTFARQLEYAPVLAVLDSPEADDEDRELLAQLHPTARQVPIGHGDLTGAQRTKGMSGAHSPLAHAALAGFDVEAAAAAQHPACALLPTEADAHGVSTLVWHRCRPFHPERLYQALEDLTCAAARSRGRFWLADKPDTLLHWDAAGGALCVESAGPWLASLPDAAWDMVPPVRRAAAALDWHPEHGDCCQHLVFTSPGLDREGLTHLLESCLLTDAEYAAGRDAWKQLPPAFDTLLEV
>NZ_CP053109.1|WP_171109681.1|3939524_3939758_-|30S-ribosomal-protein-S18
MPRKADRKPAKNRPNPLDQAGISYIDYKDTDLLRKFISDRGKIRSRRVTRVSAQQQRLLARAIKNAREMALLPYSSR
>NZ_CP053109.1|WP_171109682.1|3938869_3939169_-|DUF397-domain-containing-protein
MDHDVYDGDAYDGHVHHGAGASGVYNGMAATKLRGVAWQKSRHSNSQGSCVEFARLPGGRVAVRNSNFPDGPALVYTRAEIEAMLLGVKDGEFDHLIAG
>NZ_CP053109.1|WP_171109683.1|3938246_3938759_+|ATP-binding-protein
MGTNGSTMLEPLRQGLPPLDPTAVSNAASCALPARYEAVREARHFTRRTLDQWDVGHRFDDVCLVVSELVTNALRHALPAVAPRPADRAGEHEPPQVRLHLMRWTERMVCAVRDPSNDSPVAREADDFSAESGRGLFLVDSFCDSWGWHPLAGTLSGKVVWAMFRLQPEA
>NZ_CP053109.1|WP_171109677.1|3944148_3945345_-|DUF2786-domain-containing-protein
MDTSTVDRAFRAALYAPTDDRAALDTGASLLAADPAADAELTRRGLEFVAGAWRRGWQPADVVRIVRRELDDVHERLVSALILEQAPHDRPHDRPRGPRWAAQLAQLAEEPSGTAPRTDRFTHATAVLELYRVLLRLPTLETLDETQPPPQSQSQSSSRTKSHAHAKQTKSESRMLTRIRALLAKAEATGFPDEAEALSAKAQELMARHSIDEALLAGPAQGGGGPTAWRIGVDQPYEQAKAVLLDAVAAANHCRAVWNEPLGFSTVVGFEPDLEVVELLYTSLLVQATTAMTKAEAAQRAGGRKRTKTFRQSFLAAYAHRIGTRLATAAEQAATEALAAGDLLPVLASREVAVTERMESMFPETTTTRLRGVTDAAGWTEGSRAADRAEVRSRPRLD
>NZ_CP053109.1|WP_171109676.1|3945445_3946192_+|ATP-dependent-Clp-protease-ATP-binding-subunit
MATNPDITSSIRLDDLIAAIKKVHDEPLDQLQDAVLAGEHLGDVADHLIGHFVDQARRSGASWTDIGKSMGVTRQAAQKRFVPKESMDLDPSQGFSRYTPRARAVVMASHSAAKHARHAEGLPEHLILGLLAEPEGLAAKAITARGVTLDAVREAAEAVLPPAAEEAPELVPYGSDSKKVLELTFREALRLGHNYIGTEHILLALLEFENGEGVLSGLGLTKPATEEYLAEALAKIKATLDEQGEAQS
>NZ_CP053109.1|WP_171109675.1|3946227_3947922_+|bifunctional-3'-5'-exonuclease/DNA-polymerase
MADRWALAPAEDGGVEVAPLGPDGLPAGPVRREGDLAEAVRSRPYVTRWVWRSTAEVYPRLLATGVRVERCYDIEDAETLLLGHEGRYGEPRSAAAALARLRGGPVPPDPPPRAAEPGAQPPLFEPQGVRLPLDDLLAVYAEQQRRHDRTAHPDRMRLLTAAESAGMLVAAEMNRAGVPWSAQVHREVLHELLGERYAGGGEPRRLAELADEVSAAFGRRVRPDLPADVIKAFAQAGIKVGSTRRWEIESLDHPAVKPLVEYKKLYRIWVAHGWSWLQDWVRDGRFRPEFLAGGTVTGRWVTNGGGALQIPKVIRRAVVADPGWRLVVADADQMEPRVLAAISRDPGLMEVAGRESDLYQSVSDRAFSGDRAQAKLAVLGAIYGQTSGDGLKNLAALRRRFPKAVAYVDEAARAGEEGRLVRTWLGRTCPPAAGAGEDAAEEAGLPQEESLEPVVGGQEWVPGYASTNARARGRFARNFVVQGSAADWTLLLLAALRRACADMAAELVFFQHDEVIVHCPAEEAEAVVAAIREAGAVAARLTFGETPVRFPFTTAVVECYADAK
>NZ_CP053109.1|WP_171111587.1|3947949_3951582_-|tetratricopeptide-repeat-protein
MRCGPRFGLRFGLLGPPVLYEPCEGERYEHADDSRASYDVGGAGAGRPGLAVRAVGSPKARVLLAALLLEAGRVVPVASLKDALWGGAPPPSAHASLHNHVARLRRMLDDPGRLRAVPPGYLLRVEQRELDVHVFESHVAAARAAHAGREWERTVRECTRALALWRGAPLSGLPAEVGGYAFVQRLVEARLLVLEWRYDAELALAEPGAAGRDRLAGLVPELAALAAEYPLREAYHRQLMLALHRTGRHAEALAVHRDLRTRLVEELGVEPGAGVREAHVEVLRGGVPEGDGEGQEELSGEAVSTGSVVRTAVNAGPGVCAQAPAPLPSQLPPPPAHFTGRSAVRDALLASLTQPAALAVVSGMAGVGKSALVLHAAHALAERFSDGQLYVNLHGATPGMNPLTPGQALTALLRDLGVDPRRVPEHPDAAAALLRSLLAPTCTLMVLDDAASAAQVRPLLPAGAGCAVIVTSRSPLTALDGARRFPLTPLSSAESAALLRAVSGRDGLDADHPLVELTGRLPLALRVVAARLAARRALTPDVLAGQLAATEGRLHHLEYDDLSVRRSLAVAHDALAASDREADRDAALALRRVGALDLPTYGASLIARLTGTDERRAEAALDRLVDVALLEETAYARYAPHDLVRDFARELAAGRHSADDAGERDRAFESAPVEGEPDGLTEAGRARGAVPVEGEPDGLTGAGRARSVAPVEGERDGLTGAGRARTAAPVEGRRDEITDTTRARTAAPATGRRDEITDTTRARTAAPATGRRDEITDTTRARTPAPAEGHRDDTTDTTRPRTPAPAPHPPRTVHVGTHAARPRTPAYPHAVDDLVDTALRWYAATAERTLTAIVEPGLDQDDRRRPTVAQPPEHAAYVTTVAAFDGSEAAFAWGDGELGNVVALVEAYADGACERRAAYLSTLLRLLFPYLHRSGRVPEMELLGRAALGLARRLGDAAAEAYALGDLAGMHFLTGRQSEALALNDQALAIWRRLGVVSWIRRCLNNRGLLLEGLGRYAESEDALRQSLGYSRQLNDPYGEAVTYSHLGNLYEHTDPRAAIEQHRRSLALGAGIRAVIVQHSAHCNIGYAHLALGEPAAAVEHFEESLRVLGGHADWHGESQTRLGLVRALRQLGRTERAERECAELLRRADARSDRYTGGLGRHQYGLLLRDQGREDDAHQAWRTALADLDGTDEHAVVTELRSLLPSAS
>NZ_CP053109.1|WP_171109674.1|3952090_3953050_+|D-2-hydroxyacid-dehydrogenase-family-protein
MRYRCAVLDDYQGVATAIADWTPLGDRVEVIPFPDHFPTEDELVAALADFDFVVTLRERVPFPASLLDRLPRLKLLIASGMRNSVIDYAAAQANGVTVCGTESSPTPPVELTWALVLGLARGIVQENTALRTGGPWQSTVGADLHGRRLGLLGLGKIGSRVARIGLAFGMEVTAWSQNLTKERTDELGVHLSPTKEDLLTTSDVVSVHLALSDRTRSLLGPAELALLKPTAYLINTSRAAIIDQEALLTALHEGRIAGAAVDVYDTEPLPTDHPLRTAPHLLATPHLGYVSHANYERYYNQAIENIQAYLNGTPIRLLG
>NZ_CP053109.1|WP_171109673.1|3953063_3953738_-|hypothetical-protein
MVRECWFCGNATSASWHDRVLGLHRDTDTTMTPWIVVLRTTWRQETVHVPRCARCHTGHQIEQAAAMLSIAALIAYAASGQLDRLLGILPTSAGGRTVAAIWAAVACLPALTWIAVRHGWLPWRRLAPHRLSYARHHPEFLRLLDEGWKPRPGPFPHWGNPPNPHPPPPSRFRRLIGGVIDLVGTACVIAVPISYFQGYEELAGGFIAATAGLFFLSSKIKPEN
>NZ_CP053109.1|WP_171109672.1|3953751_3954249_-|hypothetical-protein
MNILRRPKFWVRLVSVAALLGAGWLLLVPRTAAYFVDDEGHPYDMSVLYSWDTSDQAMILPGGFFEDDDSGGQDGLVSMVRLDCGTAFTAGENEDWRPGDGEEACSEVETPRRFFGVCLILLGSAGLWAAPRLAHLRSRMPWMPWATRGSEGDEGRRLSGGPGRP
>NZ_CP053109.1|WP_171109671.1|3955580_3957188_-|alpha/beta-fold-hydrolase
MYTRRTHRRSRTMFSARSRTGATFLALVALVVSACSSGSSTSSASSPAAQAAALAALPQATPSALASYYGQKLSWRSCGVPGFECATLRAPLDYARTDAGDVRLAVARKKATGPGKRLGSLLVNPGGPGGSAVGYLQSYAGIGYPAQVRARYDMVAVDPRGVARSEPVECLDGRKMDAYTQTDVTPDDQREVDGLVDAYKGFAEGCGADAPELLRHVSTVDAARDMDILRAALGDRKLTYVGASYGTFLGATYAGLFPKRVGRLVLDGAMDPTVSARRLNLEQTAGFETAFKAFAKDCVRQAGCPLGGRGAGPEQVGRALKAFFDKVDAKPLPTGDADGRRLTESLATTGVIAAMYDEAAWQQLREALTAAMKKNDGAGLLVLSDSYYEREADGRYSNLMYANAAVNCLDLPPAFGTPDDVRKSLPAFEKASPVFGEALAWAALNCAYWPVAPTGEPHRIEARGAAPIVVVGTTRDPATPYRWAQSLSRQLSSGRLLTYDGDGHTAYGRGSECIDRTINTYLVRGTPPTDGKRCS
>NZ_CP053109.1|WP_171109670.1|3957442_3958648_-|DNA-polymerase-III-subunit-delta'
MSVWDDLVGQERVSEQLTAAARDADALVTAAAADAPLPEASKMTHAWLFTGPPGAGRTQTARAFAAALQCVSPDRALGGAPGCGFCDGCHTALVGTHADVTTVVAVGAQILVDDMRDTVRKSFTSPANGRWQIILVEDAERLNEKSANAVLKAVEEPAPRTVWLLCAPSIEDVLPTIRSRCRHLNLRTPSVEAVADMLVRREGVEPDVAAAAARATQGHVDHARRLATDPAARARRAAVLKLPLRVDDIGGCLKAAQELVDAAAEDAKQLAEEMDAKETEELKAALGAAQGGRMPRGTAGVMKELEDRQKRRRTRTQRDSLDLALTDLTAFYRDVLTLQLGSRIALANTDAEDALERLARGSAPESTLRRIEAIAACRDALDRNVAPLLAVEAMTMALRAG
>NZ_CP053109.1|WP_171109669.1|3958809_3962046_-|dTMP-kinase
MTRAEQPTAHHPAPDDALVADSRERAVRALLRRPQLKRLWSAQLVSGIGDVLALLVLVVLVLQAAIAEGSFGGGYRGVAFAVATVFGVRILATLLFGAVLLGPLSSLTSQDGPLDRRWTMVGADGLRAALLIVAPLWIDWTPDDALAVLLVTVFVTGVAERFWTVCRESAAPALLPAPPPEGATVRPLPDHMDALRRLSLRTSFVAVPLAGAALVVAGLFNNLLGAGVDWFDQHQAALASYVAAGLFAASLSVLTFLEVPGTRTPRARSPLEGLRRPRTADGGDKGRTGAMPLLVLACAAVAAAVAAVVAVSVLHAKDLGGGPVTYGLLVCLLTGGVVVGIRTAPKVLVSLSRRRLLALAIAFTGVALLAAGLVPDVATVLLIVALAGVGAGVAANTGHTLLDQEAEDFRRARTTEHLHAVVRVFVALGALIAPLVAALIGPHRLESGKFVFAHGGAAFTLMLVGALLLPVAALVLAKLDDRSGVPLRQDVRHALLGGDDPEPTPAASGFFIALEGGDGAGKSTQAEALAEWIRAKGHEVVLTREPGATPVGKRLRSILLDVSSAGLSHRAEALLYAADRAEHVDTVVRPALERGAVVISDRYIDSSVAYQGAGRDLSPTEIARINRWATHGLVPHLTVLLDVSPETARERFTEAPDRLESEPAEFHARVRSGFLTLAAADAGRYLVVDAGQESEAVTTVIRHRLDQLLPLSEAEVKAQEEARRKAEEEARRKAEEEAARKAEEERLERERQEQLARLRAEEEERKRRELEEAQRREAERQAEEARQRAEEARRRAEEERARLLAEEQARAEEEARRKAEEERRRKQAEEEARIRAEAEAQRLEKQRKAEEALLRAEEARRAAEQAAAAAAAGPRQPTAPATPTVPPDAATVPTPVVTPTNASGGPVEDTAVLRPVRPGAEGPDTGGSDAEVTAELPQPGVAPGAGDETAVLPPVERRGGAGEPSGAADETAVLPPVVPGAADETAVLPPVRGEGPADRVPPGFFRDERSGAGPDGTEDRTRELPQVDADGRPQRRQRPDWAEETPLDDLPSLADELLGPHEDDYDDEQDQRGKGRGR

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Crispr_ID: NZ_CP053109_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053109_6

4898492-4898593

Orphan

Consensus_repeat	Method
CGCGACACCGACCACGGCCCGACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP053109_6

>merge|NZ_CP053109|6|4898492-4898593|CRISPRCasFinder
CGCGACACCGACCACGGCCCGACCCTGGCCCGAGTCCTGGACCACCTCACGGAAGCGCCCCCGACCCCGGACCACAACACCGACACCGACCACGGCCCGACC

>NZ_CP053109|6|4|4898492-4898593|CRISPRCasFinder
CGCGACACCGACCACGGCCCGACC	CTGGCCCGAGTCCTGGACCACCTCACGGAAGCGCCCCCGACCCCGGACCACAAC
ACCGACACCGACCACGGCCCGACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053109.1\|WP_171119177.1\|4888980_4890528_+\|DUF3987-domain-containing-protein	unknown	unknown	gnl\|CDD\|379041
NZ_CP053109.1\|WP_171117695.1\|4901431_4902331_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|237571
NZ_CP053109.1\|WP_171117689.1\|4890870_4891098_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378935
NZ_CP053109.1\|WP_141312904.1\|4907600_4908281_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurQ	unknown	unknown	gnl\|CDD\|235140
NZ_CP053109.1\|WP_171117699.1\|4904471_4905236_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|378925
NZ_CP053109.1\|WP_171117682.1\|4886289_4886484_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171117705.1\|4910668_4911466_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|380033
NZ_CP053109.1\|WP_171117691.1\|4895659_4896913_+\|phosphoribosylamine--glycine-ligase	unknown	unknown	gnl\|CDD\|234856
NZ_CP053109.1\|WP_171117687.1\|4887291_4887801_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171134061.1\|4892870_4895297_+\|DNA-polymerase-III-subunit-gamma-and-tau	unknown	unknown	gnl\|CDD\|236090
NZ_CP053109.1\|WP_171117703.1\|4908277_4910536_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurL	unknown	unknown	gnl\|CDD\|234921
NZ_CP053109.1\|WP_171117694.1\|4899832_4901362_+\|phosphoribosylamine--glycine-ligase	unknown	unknown	unknown
NZ_CP053109.1\|WP_171119175.1\|4887950_4888808_+\|bifunctional-DNA-primase/polymerase	unknown	unknown	gnl\|CDD\|214927
NZ_CP053109.1\|WP_171117683.1\|4886499_4886967_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_141312900.1\|4906701_4907019_-\|Lsr2-family-protein	unknown	unknown	gnl\|CDD\|378714
NZ_CP053109.1\|WP_171117685.1\|4886983_4887274_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171117701.1\|4907328_4907604_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurS	unknown	unknown	gnl\|CDD\|235659
NZ_CP053109.1\|WP_171119179.1\|4891181_4892468_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NZ_CP053109.1\|WP_141316514.1\|4902469_4903078_-\|response-regulator	unknown	unknown	gnl\|CDD\|225107
NZ_CP053109.1\|WP_171117697.1\|4903074_4904364_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951

Protein	Function_ID	Function_description	E-value
NZ_CP053109.1\|WP_171119177.1\|4888980_4890528_+\|DUF3987-domain-containing-protein	gnl\|CDD\|379041	pfam13148, DUF3987, Protein of unknown function (DUF3987). A family of uncharacterized proteins found by clustering human gut metagenomic sequences.	9.62523e-106
NZ_CP053109.1\|WP_171117689.1\|4890870_4891098_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	3.9048e-10
NZ_CP053109.1\|WP_141312904.1\|4907600_4908281_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurQ	gnl\|CDD\|235140	PRK03619, PRK03619, phosphoribosylformylglycinamidine synthase subunit PurQ.	4.67807e-145
NZ_CP053109.1\|WP_171117699.1\|4904471_4905236_-\|ABC-transporter-permease	gnl\|CDD\|378925	pfam12698, ABC2_membrane_3, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	2.12152e-09
NZ_CP053109.1\|WP_171117705.1\|4910668_4911466_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|380033	pfam17844, SCP_3, Bacterial SCP ortholog. This domain is found in MSMEG_5817 gene product from M. smegmatis. It has been shown to be vital for mycobacterial survival within host macrophages. Crystal structure revealed a Rossmann-like fold alpha/beta two-layer sandwich forming a highly hydrophobic interface cavity and with high structural homology to the SCP family. Hence, it has been suggested that this domain may be involved in the interaction of apolar ligands through its hydrophobic cavity. Alanine-scanning mutagenesis of the hydrophobic cavity of MSMEG_5817 protein demonstrated that the conserved Val82 residue plays an important role in ligand binding.	2.58976e-50
NZ_CP053109.1\|WP_171117691.1\|4895659_4896913_+\|phosphoribosylamine--glycine-ligase	gnl\|CDD\|234856	PRK00885, PRK00885, phosphoribosylamine--glycine ligase; Provisional.	0
NZ_CP053109.1\|WP_171134061.1\|4892870_4895297_+\|DNA-polymerase-III-subunit-gamma-and-tau	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0
NZ_CP053109.1\|WP_171117703.1\|4908277_4910536_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurL	gnl\|CDD\|234921	PRK01213, PRK01213, phosphoribosylformylglycinamidine synthase subunit PurL.	0
NZ_CP053109.1\|WP_171119175.1\|4887950_4888808_+\|bifunctional-DNA-primase/polymerase	gnl\|CDD\|214927	smart00943, Prim-Pol, Bifunctional DNA primase/polymerase, N-terminal. Members of this family adopt a structure consisting of a core of antiparallel beta sheets. They are found in various bacterial hypothetical proteins, and have been shown to harbour both primase and polymerase activities.	1.75885e-16
NZ_CP053109.1\|WP_141312900.1\|4906701_4907019_-\|Lsr2-family-protein	gnl\|CDD\|378714	pfam11774, Lsr2, Lsr2. Lsr2 is a small, basic DNA-bridging protein present in Mycobacterium and related actinomycetes. It is a functional homolog of the H-NS-like proteins. H-NS proteins play a role in nucleoid organisation and also function as a pleiotropic regulator of gene expression.	4.07725e-50
NZ_CP053109.1\|WP_171117695.1\|4901431_4902331_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|237571	PRK13961, PRK13961, phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional.	0
NZ_CP053109.1\|WP_171117701.1\|4907328_4907604_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurS	gnl\|CDD\|235659	PRK05974, PRK05974, phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed.	1.90707e-39
NZ_CP053109.1\|WP_171119179.1\|4891181_4892468_+\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	1.03527e-26
NZ_CP053109.1\|WP_141316514.1\|4902469_4903078_-\|response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	5.68368e-61
NZ_CP053109.1\|WP_171117697.1\|4903074_4904364_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	8.57301e-35

>NZ_CP053109.1|WP_171117691.1|4895659_4896913_+|phosphoribosylamine--glycine-ligase
MKVLVIGTGAREHALCRSLSLDPAVTALHCAPGNAGIAEVAELYPVDALDGAAVSALAAQLGADLVVVGPEAPLVAGVADAVREAGIAVFGPSKEAARLEGSKAFAKDVMAAAAVPTARSYVCTTEAEVDEALDAFGPPYVVKDDGLAAGKGVVVTADLDAAKAHARACDRVVIEEYLDGPEVSLFAVTDGETVLPLQPAQDFKRALDNDEGPNTGGMGAYSPLPWADPKLVDDVLHSVLQPTVDELRRRGTPFSGLLYAGLAITGRGVRVIEFNARFGDPETQVVLARLKTPLAGILMAAATGNLANLEPLRWSDDAAVTVVVASHNYPGTPRTGDPITGLDAVAELDAPHAYVLHAGTKRDGDTVVSAGGRVLSVTATGGDLGEARERAYRAVSRIHLDGSQHRTDIAAKAATGA
>NZ_CP053109.1|WP_171134061.1|4892870_4895297_+|DNA-polymerase-III-subunit-gamma-and-tau
MSSLALYRRYRPESFAEVIGQEHVTDPLQQALRNNRVNHAYLFSGPRGCGKTTSARILARCLNCEQGPTPTPCGECQSCRDLARNGPGSIDVIEIDAASHGGVDDARELREKAFFGPASSRYKIYIIDEAHMVTSAGFNALLKVVEEPPEHLKFIFATTEPEKVIGTIRSRTHHYPFRLVPPGTLRDYLAEVCQKENIPVEDGVLPLVVRAGAGSVRDSMSVMDQLLAGAGADGVTYAMATSLLGYTDGSLLDSVVEAFATGDGAAAFEVVDRVIEGGNDPRRFVADLLERLRDLVIIAAVPDALEKGLIDAPADVLERMQAQAGTFGPAELSRAADLVNEGLTEMRGATSPRLQLELICARVLLPAAYGDERSVMARLDRLERGVNFSTGAGAPAMGYVPGPDAHGSAHAGAGAGAAVPPGGGAAAARAAVRASGGAAGTSEAAGGAVAGAPAGQGAPAGQGAPVAPGDQRGDVRPGAPGAPTPPGTGEPAQQPPAAPAPTPPAAPAPGPVATPGAWPTATPAGSGGVGRRPGGWPTAAPPGGGGRPQTAPSPSAPSPPPTPAPTPTPAPASALAASPPPTGGLDPRSLWPNILEAVKNRRRFTWILLSQNAQVTGFDGTTLQLGFVNAGARDNFASSGSEDVLRQALAEQFNVQWKIEAVVDPSGGGSAPPAPGNSGGGGYGGAGTPGGYGGGGGGATSGYSGGGTASGYGGGTPGGAGGGTATAQRSAPTQPTSAAPAQPTAVPAPAATPAPTPAPPSAPEPPPVSIEDDIPEDDDPDLDESALSGQELIVRELGATVMEEFSND
>NZ_CP053109.1|WP_171119179.1|4891181_4892468_+|site-specific-integrase
MAEEKKRTRRANGESAIYFGKDGRWHARVPMGYKDDGTPYRRHLTRQTRQKLVEAVKELEKQRDQGSTQQPGKPWTVEKWLWHWVENIAKPTVSENTYDGYEVAVRVHLVPGVGKHRLDRLQPEHLESLYRRMQANGERKAGTAHQTHRTARTALGEAVRRGYAAKNAAALAKPPRVEEDEAEVEPYSVEEVQRLLLEANKRRNSARWMLALALGLRQGETLGLRWSDVDLDNEYLKLRRNRLRPRYKHGCPEASPCGRAKAGYCPDKVQIRRETKNTKSRAGRRAVPLPGPLVAMLRAHAEEQERERKAAGDLWVESDYVFTKMLGGPLSPNTDYHDWKRLLEDAGVRDGRLHDARHTAATVLMLLGVPDRVIDQIMGWEPGTSASMRARYLHVPDAMLKDVARKIADAIWGPPETPPVDKNQDNDG
>NZ_CP053109.1|WP_171117689.1|4890870_4891098_+|helix-turn-helix-domain-containing-protein
MNDHGTPTTLTDDDPTLVLLTVEEAARRLRIGRTTCYGLIRSGELESVPVGRLRRVPADAPAAYVARLRTAHHAA
>NZ_CP053109.1|WP_171119177.1|4888980_4890528_+|DUF3987-domain-containing-protein
MDNPDLWAGLSTLEAPPGEGETAPEVWEDPIPLTGRRERPPFPARVFPTWLREFVTAVAEETQTPADLAGSIALAVLATAAGGRSVVHVRGNWREPTNLYTVVALPPANRKSAVFALLTNPLYEAEKQLKTAMKPVIVEAELTARLAKEAADKAAAKAASADPDKRDEMVAIAVGLAQTADTLTVPAEPVLLADDSTPETVTSLMAEQGGRLSVMSAEGGIFDIIAGRYSGAPNMEVFLKGHAGDRLRVNRQTRREYIDAPALTIGLAVQPDVLRDIGKVKGFDGRGLLARFLYSLPVSRVGERKIITDPIPEGTAAKYASNVVGLTLSLAEWTDPAVIQLTPEADVALIAYQERVEPMLKARGGKLGHISNWAGKLAGATARMAALLHLAEHLGDGYARPVPEATMNAAIELGEYYTAHALAVFDAMGADPVLSRARSALEALRDNEWEDVSRRDLFTAMSRAEVPTVADLEPALALLEDHGYVRTYQPERTGRRGRPPAPRLLVHPQVRRFGR
>NZ_CP053109.1|WP_171119175.1|4887950_4888808_+|bifunctional-DNA-primase/polymerase
MRTALTLATAGVPVLPLRHGKVPFGNCRACADNACGGRPNMKRAGTCRCLAPCHAWAAATTDPSVITSPEWTAAWRHAVAVAYHPGGAGLTVVDLDTPAAVAWARETLPATRTVPTTRGEHWIYRGAMRSSNGVRPGVDIKSLMNYARWLGSGTGRMTALPSAVRGLAVREDTTPAAGRVVSSVSARATWNRSVATGCRHTERYVRTGLERGLALVRARTESGAGSQTFGVAQFLAAQHAQCPGPCGLDAIAEEIVAAAVSVGVPETYARRAVINGLETAGELAA
>NZ_CP053109.1|WP_171117687.1|4887291_4887801_+|hypothetical-protein
MFEIRVICDPADADRITTALGAAFATGIVRDYPTRDGQRRRLYVTADHRPEPGLWPTPDEAYALAPSMVREIGWTAGTAADKPFGESLGREYWLRKAALLDRIALRDEEDGLSGDAAEVATEAARRLIAHDRDGEGDYHGASYWPEHPATAADPRGYVRQEYAHWAKNH
>NZ_CP053109.1|WP_171117685.1|4886983_4887274_+|hypothetical-protein
MPRLRIQVANWPRRSLVLTDTPRPDCSNCEGLGGIEHDYGDHNGEYAGTDWEPCHCWNESRRWTLLPLPRVPRWLYRHDRGRDPWGPDGYSNEPPF
>NZ_CP053109.1|WP_171117683.1|4886499_4886967_+|hypothetical-protein
MNEPTAYRRPAGPDTAAVEVHHPAPITPAHTAPLVPVQPGAIPAVASVVLPDGRVVTGYAIEPAKPERVATKPPVSRAAVNIALGGVGFLAVCGGLFLLTAFITALTALITQLIVLAAVVFGGWVAVQVLSASGHGGGTTVNIRKAVIKRNKFYG
>NZ_CP053109.1|WP_171117682.1|4886289_4886484_+|hypothetical-protein
MVITIPLVLLLAAVVLLLLRFRAVGAGAAVVVALFGFYLAGTGASDTVNQLVTAVTGALADIGR
>NZ_CP053109.1|WP_171117694.1|4899832_4901362_+|phosphoribosylamine--glycine-ligase
MGSEKIRRWDSGALAHAVTDPFGQGPLPWLRGSETYFDDTGKVVPWYLDPAPGAQQPHTSGAQQTQTQGTATPRVPAPRSGGPRAADDVHRQIKGFVSTGAVTPGEAVDFHVTVDPPQEFAVDIYRIGHYGGDGAAKITTSPRLSGIVQPPPLTADRTVSCHHWWLSWRLQIPSYWTVGAYVAVLTTADGYRSHVPFTVRDDHPADLLLLLPDVTWQAYNLYPEDGRTGASLYHAWDDNGRLLGEADAATTVSFDRPYAGAGLPLHVGHAYDFIRWAERYGYDLAYADARDLHAGRVDPTRYRGLVFPGHDEYWSANMRRTVELARENGTSLVFLSSNSMYWQVELGPSPSGTPDRLLTCRKRKGPGKPVLWREIDRPEQQLIGIQYAGRVPEPHPLIVRNAGHWLWEATGAHEGDEIAGLVAGEADRYFPRTPLPDHDERILLAHSPYTDSEGIRRHQETSLYRAPSGALVFAAGTFAWSPALDHPGHVNPVIQRATANLLDRICKRD
>NZ_CP053109.1|WP_171117695.1|4901431_4902331_+|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MSGFVEKPEPTEVPGLVHLHTGKVRELYQNEAGDLVMVASDRISAYDWVLPTEIPDKGRVLTQLSLWWFDQLADLVPSHVLSTDLPDNAPADWAGRTLVCKSLRMVPVECVARGYLTGSGLVEYNDSRTVCGLALPEGLVDGSELPAPIFTPATKAEVGEHDENVSYEEVARQVGADTAAELRQATLAVYSRARDIARDRGIILADTKFEFGFDGDTLVLADEVLTPDSSRFWPADQWQPGRAQPSYDKQYVRDWLTSPESGWDRRSEQPPPALPPQVVDATRAKYVEAYERLTGTSWS
>NZ_CP053109.1|WP_141316514.1|4902469_4903078_-|response-regulator
MTVRVLLADDEHLIRGALAALLSLEDDLMVVAEAASGPEALAMARAHEPDVAVLDLQMPGADGVKVATSLRAELPGCQVLIVTSHGRPGHLKRALAAGVRGFVPKTVSAQRLAEIIRTVHAGNRYVDPELAADAISAGDSPLTAREAEVLELAADGAPVAEIAERAALSQGTVRNYLSSAVSKLGVENRHAAVRLARERGWV
>NZ_CP053109.1|WP_171117697.1|4903074_4904364_-|sensor-histidine-kinase
MTRPGQWWRRKSTPAKVETYTRWSFHFFALIEVGVFGLPLLGQGRLPHAVWLFLLVCGHALFAALVGSRALDWTRGLRPQPLRLMWALGAVSALVAGTLLVLVDRGVGGDDTATVLGTLFAGLLGFGGGSITLGIRSRRRVLGLVLGFSAGTGLVVFALGGPAVVAVAMALTALVAMGFFAFTSVFSVWLLNAVYELDAARETRARLAVAEERLRFGRDMHDVMGRNLAVIALKSELAVQLARRGRAEAVDQMIEVQRIAQESQREVRDVVRGYREADLGAELAGAQGVLTAAGIACEVSGEGAAAGLPGEVQSALGWVVREATTNVLRHGDAGLCVVGLRMTEGRVVLTVENNGGLTMENKMENNGASEANGNGPSGATGSGGGSGLAGLRERLAAVEGTLEAGPVGDGVFRVVAEVPLTSVVHEVAR
>NZ_CP053109.1|WP_171117699.1|4904471_4905236_-|ABC-transporter-permease
MTTVTGRMNALARAELTLLGRSRATLVTAVLIPLLLPLSVRSAIDGMDLAEAGLTVGTVLLPAAIGFSLLFAVYAALTSVYVVRREELVLKRLRTGELRDGEILVGAALPASGIGLVQCVLLAAGCTVLMDLGAPPAPLLAVAGVLLGLVLCGALAAVTAAFTRTAESAQVTSLPMMFVSMLGSGVAVPLEVLPDRLASVCELLPLTPAITLVRGAWTGDLPASEALGALAVALAWIVAAVFAVRRWFRWEPRR
>NZ_CP053109.1|WP_141312900.1|4906701_4907019_-|Lsr2-family-protein
MAQKVVVTLFDDIDGSEAAETIAFGLDGKSYEIDLNEANAKKLRKALAPYVEAGRKRSKSGKAYRQTEVAPDPAAVRAWAQANKMDVPARGRIPKKVYEAFAAAQ
>NZ_CP053109.1|WP_171117701.1|4907328_4907604_+|phosphoribosylformylglycinamidine-synthase-subunit-PurS
MARVVVDVMLKPEILDPQGQAVQRALPRLGFDGISDVRQGKRFELEVDGPVDEAALTRIHQLAESFLANTVIEDFSVRVDNNEAHAAEAVK
>NZ_CP053109.1|WP_141312904.1|4907600_4908281_+|phosphoribosylformylglycinamidine-synthase-subunit-PurQ
MTARIGVVTFPGSLDDRDTQRAIRIAGAEPVALWHKDKDLKQVDAVVLCGGFSYGDYLRAGAIARFSPVMEPLIEQAKAGLPVLGICNGFQILTEAHLLPGAMLGNDHLHFICRDQKLRVESANTAFTSDFVAGQEIHIPLKNMDGRYVADARTLDMLEAEGRVVFRYLDFNPNGSLRDIAGITNEAGNVVGLMPHPEHAVEPLIGTGRTDGLPFFTSILKKLVNA
>NZ_CP053109.1|WP_171117703.1|4908277_4910536_+|phosphoribosylformylglycinamidine-synthase-subunit-PurL
MSRTPLDTVEHAAATPDVALPWAELGLKKDEYERIVEILGRRPTGAELAMYSVMWSEHCSYKSSKVHLRQFGEKAPQSDALLVGIGENAGVVDVGQGYAVTFKVESHNHPSYVEPYQGAATGVGGIVRDIIAMGARPVAVVDPLRFGAPDHPDTKRVLPGVVAGIGGYGNCLGLPNIGGEVVFDACYQGNPLVNAGCVGVMRHEDIHLAKASGAGNKVILYGARTGGDGIGGASILASETFDDAKPSKRPAVQVGDPFQEKLLIECTLEAFAEKLVVGIQDLGAAGLSCATSELASNGSGGMTVVLDDVPLRDSTLSPEEILMSESQERMCAVVEPGKVDRFLQICEKWDVIATVIGEVTDGDRLEIFWHGEKIVDVDPRTVAHEGPTYERPYARPSWQDALQADDAGKLPRPETSKELKEQVLQLVASPNQASKKWITSQYDHFVQGNTVLAQPEDSGMIRIDEKTGLGVAIATDGNGRYAKLDPYKGAQLALAEAYRNVATTGAKPLAVSDCLNFGSPEDPAVMWQFAEAVRGLADACRQLGTPVTGGNVSLYNQTGEAAIHPTPVVAVLGVIDDVARRTPVGFQEDGQLLYLLGDTREEFGGSAWSQVVHDHLGGLPPEVDLERERLLAEILISASRDGMIDSAHDLSDGGLIQAVVESALLGGKGARLIVPDGLDAFTFLFSESAGRAIVAVPRSEEVRFNDMCGARGLPATRIGVVDGDSVDVQGEFALSLEELREAHEGTIPALLA
>NZ_CP053109.1|WP_171117705.1|4910668_4911466_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MPPAKKRTRSYDPAKTRAAVLAQFGNVRQAVRVLTPEQLALPTRLGDWTVRDLVAHTGMALAAVSRLLGAPEPVRQDGRLLDWPSAIAADAPAIADTARHLAEQHPDLDAHLADVERRFLADLDAHPGTRLLPTSAGALPLADYVVTRTVELVVHTDDLNAAVPGLEIPYDRQALAAATRLLADALAARAPGGSTEVRIPPYAVVQCVEGPRHTRGTPPNVVETDPLTWIRLATGRLTWQDAVTNATVSASGERADLGRLLPLMS

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Crispr_ID: NZ_CP053109_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053109_7

5569047-5569180

Orphan

Consensus_repeat	Method
ACGGATATCCGCAGCCGCCGCAGCCG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP053109_7

>merge|NZ_CP053109|7|5569047-5569180|CRISPRCasFinder
ACGGATATCCGCAGCCGCCGCAGCCGCCGCAGCCGCCTCAGGGGCAGCCGCAGCCGGGGCACGGATATCCGCAGCCGCCGCAGCCGAATCCCTACGGGCAGCCCGGCTACGGCTATCCGCAGGCGACCGTGCCG

>NZ_CP053109|7|5|5569047-5569180|CRISPRCasFinder
ACGGATATCCGCAGCCGCCGCAGCCG	CCGCAGCCGCCTCAGGGGCAGCCGCAGCCGGGGC
ACGGATATCCGCAGCCGCCGCAGCCG	AATCCCTACGGGCAGCCCGGCT
ACGGCTATCCGCAGGCGACCGTGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053109.1\|WP_171108260.1\|5577963_5578737_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP053109.1\|WP_171108228.1\|5556380_5558126_-\|phospholipid-carrier-dependent-glycosyltransferase	unknown	unknown	gnl\|CDD\|224839
NZ_CP053109.1\|WP_171108256.1\|5576023_5577196_+\|galactokinase	unknown	unknown	gnl\|CDD\|223231
NZ_CP053109.1\|WP_171108244.1\|5567124_5568840_+\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|370723
NZ_CP053109.1\|WP_171134077.1\|5570841_5571528_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP053109.1\|WP_171108248.1\|5571776_5572097_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171108249.1\|5572118_5573798_-\|sodium:solute-symporter-family-protein	unknown	unknown	gnl\|CDD\|271372
NZ_CP053109.1\|WP_171108262.1\|5578831_5579329_-\|MarR-family-transcriptional-regulator-TamR	unknown	unknown	gnl\|CDD\|197670
NZ_CP053109.1\|WP_171108258.1\|5577204_5577666_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP053109.1\|WP_171108238.1\|5562934_5563837_+\|4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol-kinase	unknown	unknown	gnl\|CDD\|235110
NZ_CP053109.1\|WP_171108240.1\|5565094_5566897_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP053109.1\|WP_171108230.1\|5558188_5559028_+\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	unknown	unknown	gnl\|CDD\|223390
NZ_CP053109.1\|WP_171111395.1\|5560697_5562017_+\|DUF348-domain-containing-protein	unknown	unknown	gnl\|CDD\|226111
NZ_CP053109.1\|WP_171111397.1\|5564038_5565022_+\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|133475
NZ_CP053109.1\|WP_171108234.1\|5559609_5560485_+\|TatD-family-hydrolase	unknown	unknown	gnl\|CDD\|238635
NZ_CP053109.1\|WP_171108253.1\|5575033_5575996_+\|UDP-glucose-4-epimerase-GalE	unknown	unknown	gnl\|CDD\|187558
NZ_CP053109.1\|WP_171108236.1\|5562038_5562938_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	unknown	unknown	gnl\|CDD\|234708
NZ_CP053109.1\|WP_171108232.1\|5559191_5559575_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171108264.1\|5579401_5580202_+\|trans-aconitate-2-methyltransferase	unknown	unknown	gnl\|CDD\|184509
NZ_CP053109.1\|WP_171108251.1\|5573975_5575037_+\|galactose-1-phosphate-uridylyltransferase	unknown	unknown	gnl\|CDD\|238341

Protein	Function_ID	Function_description	E-value
NZ_CP053109.1\|WP_171108260.1\|5577963_5578737_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	5.97278e-45
NZ_CP053109.1\|WP_171108228.1\|5556380_5558126_-\|phospholipid-carrier-dependent-glycosyltransferase	gnl\|CDD\|224839	COG1928, PMT1, Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones].	9.17648e-28
NZ_CP053109.1\|WP_171108256.1\|5576023_5577196_+\|galactokinase	gnl\|CDD\|223231	COG0153, GalK, Galactokinase [Carbohydrate transport and metabolism].	1.50459e-125
NZ_CP053109.1\|WP_171108244.1\|5567124_5568840_+\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|370723	pfam09849, DUF2076, Uncharacterized protein conserved in bacteria (DUF2076). This domain, found in various hypothetical prokaryotic proteins, has no known function. The domain, however, is found in various periplasmic ligand-binding sensor proteins.	3.57041e-07
NZ_CP053109.1\|WP_171134077.1\|5570841_5571528_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	7.11502e-32
NZ_CP053109.1\|WP_171111395.1\|5560697_5562017_+\|DUF348-domain-containing-protein	gnl\|CDD\|226111	COG3583, COG3583, Uncharacterized protein conserved in bacteria [Function unknown].	6.85929e-55
NZ_CP053109.1\|WP_171108262.1\|5578831_5579329_-\|MarR-family-transcriptional-regulator-TamR	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.63873e-19
NZ_CP053109.1\|WP_171108238.1\|5562934_5563837_+\|4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol-kinase	gnl\|CDD\|235110	PRK03188, PRK03188, 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional.	1.49148e-155
NZ_CP053109.1\|WP_171108240.1\|5565094_5566897_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	1.31459e-165
NZ_CP053109.1\|WP_171108230.1\|5558188_5559028_+\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	gnl\|CDD\|223390	COG0313, COG0313, Predicted methyltransferases [General function prediction only].	3.50826e-110
NZ_CP053109.1\|WP_171108249.1\|5572118_5573798_-\|sodium:solute-symporter-family-protein	gnl\|CDD\|271372	cd11478, SLC5sbd_u2, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	0
NZ_CP053109.1\|WP_171111397.1\|5564038_5565022_+\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|133475	cd06583, PGRP, Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 kDa) extracellular proteins; intermediate PGRPs (PGRP-I) that are 40-45 kDa and are predicted to be transmembrane proteins; and long PGRPs (PGRP-L), up to 90 kDa, which may be either intracellular or transmembrane. Several structures of PGRPs are known in insects and mammals, some bound with substrates like Muramyl Tripeptide (MTP) or Tracheal Cytotoxin (TCT). The substrate binding site is conserved in PGRP-LCx, PGRP-LE, and PGRP-Ialpha proteins. This family includes Zn-dependent N-Acetylmuramoyl-L-alanine Amidase, EC:3.5.1.28. This enzyme cleaves the amide bond between N-acetylmuramoyl and L-amino acids, preferentially D-lactyl-L-Ala, in bacterial cell walls. The structure for the bacteriophage T7 lysozyme shows that two of the conserved histidines and a cysteine are zinc binding residues. Site-directed mutagenesis of T7 lysozyme indicates that two conserved residues, a Tyr and a Lys, are important for amidase activity.	3.32956e-25
NZ_CP053109.1\|WP_171108234.1\|5559609_5560485_+\|TatD-family-hydrolase	gnl\|CDD\|238635	cd01310, TatD_DNAse, TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.	1.50086e-101
NZ_CP053109.1\|WP_171108258.1\|5577204_5577666_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.36826e-10
NZ_CP053109.1\|WP_171108236.1\|5562038_5562938_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	gnl\|CDD\|234708	PRK00274, ksgA, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA.	2.44153e-129
NZ_CP053109.1\|WP_171108253.1\|5575033_5575996_+\|UDP-glucose-4-epimerase-GalE	gnl\|CDD\|187558	cd05247, UDP_G4E_1_SDR_e, UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	8.92428e-178
NZ_CP053109.1\|WP_171108264.1\|5579401_5580202_+\|trans-aconitate-2-methyltransferase	gnl\|CDD\|184509	PRK14103, PRK14103, trans-aconitate 2-methyltransferase; Provisional.	3.7751e-128
NZ_CP053109.1\|WP_171108251.1\|5573975_5575037_+\|galactose-1-phosphate-uridylyltransferase	gnl\|CDD\|238341	cd00608, GalT, Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme contains two identical subunits. It also demonstrates that the active site is formed by amino acid residues from both subunits of the dimer.	7.79919e-113

>NZ_CP053109.1|WP_171108244.1|5567124_5568840_+|PQQ-binding-like-beta-propeller-repeat-protein
MTQPPNQPPGGGFGAPQDPSQGTPPPPAQPPQGPPQPGYGYPQQPGPYAQPQQPGPYNTPGPYGQPQPPGPYGQQPGYGYPQPQYPGVPGTPPGSGSRNPFRGKPALAVGAAVAALLVIGGTVYAVTSGGDDDKKPVAEQSDDARPSASDTPVNPGDGSGGGADPDDLNEGRKAGEARVLWYKEAPDAPGSGAKAPGMWITDKTAVKAAYKELVAYNVGDGKPTWDPIVFPQEICAVTAQKTADDKIVVAYMNGSSDRADCNQLQLVDLNTGEKGWSGEVEDGALFDSTLSIELTLAGNTLMVGRSQSGTAYDVTTGKKLFDKKKYEGACFPSAFAGGSRLISVASCGAATDNEHNEIQELDPRTGKVKWTRAFGAGWRIMRTYSVDPLVVYSVNEDKKTWNISTLDAKGEIRSQVKIDEDFAPECGFSVLQRDLSGCQGVAADANTLYLPTEATSGANEVVAINLADGKEKWRVKSPADESMLPLRVEGDKLIAYVEASYDAGGQIVSVPTTGGSHQPTKLLQNPTGAAEVEDGFFSRDIAWVDGRFYISTTRLSGEDEAKEKLMLAYGK
>NZ_CP053109.1|WP_171108240.1|5565094_5566897_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MAVNLVNVENVSKVYGTRTLLDGISLGVSEGDRIGVVGRNGDGKTTLIRMLAKQEEADSGRVTHSGGLRLGVLTQHDSLDPEATVRHEVIRDLADHEWAGNAKIRDVLTGLFGGLDLPGFPQGLDTVIGPLSGGERRRIALAKLLIDEQDLIVLDEPTNHLDVEGIAWLAQHLRERRSALVCVTHDRWFLDQVCTRMWDVQRGVVHEYEGGYSDYVFARAERERIAATEEVKRQNLVRKELAWLRRGAPARTSKPRFRVEAANELIKDVPPPRDSSELMKFASSRLGKTVFDLEDITVQAGPKVLLKHVTWQLGPGDRIGLVGVNGAGKTSLLRAMADAARTQGEAQPAGGRIAVGKTVKLAYLSQEVAELDPNWRVLEAVQQVRERVDLGKGREMTAGQLCETFGFSKEKQWTPVGDLSGGERRRLQLLRLLMDEPNVLFLDEPTNDLDIETLTQLEDVLDGWPGSMIVISHDRFFVERTTDRVFALLGDGTLRMLPRGIDEYLERRRKMEEAAAAAVSAAVRSAPEKSAADQRAAKKELQKIERQLDKITEKETKLHAQIADNATDFAKVAELDAELRQLAGEREELEMRWLELAEDA
>NZ_CP053109.1|WP_171111397.1|5564038_5565022_+|N-acetylmuramoyl-L-alanine-amidase
MVFAATDSDTPTTGAEPGTTPETFPATRTAAATGTDSLTFAASYVAVRWTGAPDGAGIRFPDGTWQPLTAGCATVEDGGTALVAAGAATSYEVKAPAGAQRVRSLAIDCADGPGRTFRVPSQPTRMRGVRYLSRPAWGADESKRYKDGKVNSPEQYFPLQTITVHHTATPNADPDPAATVRSIYEFHAITNDWGDIGYHFLIDEAGVIYEGRYSGDDGIPAFDPDGNLVTAFHAVGFNSGNLGIALLGTLDDQGPTHAAKRSLTRLIKAIARFKGLDPQANTTFVNPVNGVTKDVPVISGHRDWLQTECPGQTMYDLLAEVRTTAAR
>NZ_CP053109.1|WP_171108238.1|5562934_5563837_+|4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol-kinase
MSVTVRVPAKVNVQLAVGAARPDGYHDLANVFLAVGLYDEVTVTEADELRVTCEGPDADQVPLDRTNLAARAAEALAARYGRTPDVHVHIAKDIPVAGGMAGGSADGAGALLACDALWGTGASRAELLDICAELGSDVPFSLIGGAALGTGRGERLTVLDVGGTFHWVFAMADRGLSTPAVFREFDRLGEGTDIPEPVASRDLLDALAKGDPDALAAAVSNDLQPAALSLFPALADTLAAGRAAGALTALVSGSGPTTAFLARDPESAAKVAEVLRASGTCRTVRTASGPAPGATVTARR
>NZ_CP053109.1|WP_171108236.1|5562038_5562938_+|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA
MSSPSPDALLSPADVRELAEALGVRPTKQRGQNFVIDANTVRRIVRTAQVRPDDVVVEVGPGLGSLTLALLEVADRVTAVEIDDVLAAALPATIAARMPARADRFALVHSDAMHVTELPGPAPTALVANLPYNVAVPVLLHMLDTFPSIERTLVMVQSEVADRLAAPPGSKVYGVPSVKANWFAEVKRAGAIGRNVFWPAPNVDSGLVSLTRRTEPIKTTASQREVFAVIDAAFAQRRKTLRAALAGWAGSAAAAEAALVAAGVSPQARGESLTVEEFARIAEAASSRGATPAPPKESQ
>NZ_CP053109.1|WP_171111395.1|5560697_5562017_+|DUF348-domain-containing-protein
MHGVPTLPDGATYATHATHTTHAAYGTYGDTYRPAYETAEPALPRQGAPEAPAAVVRPRVDRRAARRRRGRYAERPDVSVRRLLPRALVVAFLAGGTSAFVAEDKAVELNVDGEPRRLHTFADDVGELLAEEGVEVGARDVVEPAPGTELGSGDEIAVHYGRPVRLTLDGQRREVWTTARTVEGALRQLGVRAEGAYLSISRSQRIGRAGLALDVRTERSVTVMADGRARVIRTNAATVGEVVREAGIVLRGQDTTSVPPDSFPRDGQTVTVLRITGGKEIREEQIPFEVRRIQDATVLKGTEVVERAGQPGLRRVTYSVRTVNGVREKPRRLGSEVVREPTAQIVKVGTKPLPASVRGADGLDWQGLAACESGGRADAVDPSGTYGGLYQFDAHTWRSLGGTGRPQDASAAEQTYRAKKLYTRRGASPWPHCGARLHR
>NZ_CP053109.1|WP_171108234.1|5559609_5560485_+|TatD-family-hydrolase
MPTSDKNAAPPLPPPLTVPVADSHTHLDMQSGTVEEGLAKAASVGVTTVVQVGCDVHGSRWAAETAAAYENVHAAVALHPNEAPRIVHGDPDGWSRQGAREPGGDAGLDEALAEIERLAALPHVKAVGETGLDYFRTGTEGKAAQERSFRAHIEIAKRHGKALVIHDRDAHADVLRVLKEEGAPERTVFHCYSGDAEMAEVCARAGYYMSFAGNVTFKNAQNLRDALAVAPLELVLVETDAPFLTPAPYRGRPNAPYLIPVTVRAMAAVRGIDEDALATAIGSNTARAFGY
>NZ_CP053109.1|WP_171108232.1|5559191_5559575_+|hypothetical-protein
MSEITGHTGLRNGATAVVNESYSFACMRCGHGWEQSYEIEHHVDGAGHEFVLYVADGRVVPSPLSQPTCARCGGHVVRIMRPGRVSSARNAARRHEQRPPAEVPTVPRQRHHWQLSDLLHPFQRRAS
>NZ_CP053109.1|WP_171108230.1|5558188_5559028_+|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase
MTGTLVLAGTPIGDIADAPPRLSQELARADVVAAEDTRRLRRLTQALGVTPKGRVVSYFEGNEAARTPELVEELVGGARVLLVTDAGMPSVSDPGYRLVAAAVERDVRVTAVPGPSAVLTALALSGLPVDRFCFEGFLPRKAGERLSRLREVAEERRTLVYFEAPHRLDDTLAAMAEVFGAERRAAVCRELTKTYEEIRRGTLGELAVWAAEGVRGEITVVVEGAGAPPAVGPEELVRRVRVREEAGERRKEAIAAVAAEAGVPKRVVFDAVVAAKRAL
>NZ_CP053109.1|WP_171108228.1|5556380_5558126_-|phospholipid-carrier-dependent-glycosyltransferase
MTSTASSTDTRQDQAPHEQRPSWQQRLRRFGYTPAGPRSDVRDRLVPPYAEPSPRLWAALGIRYPSAERITRWSGWGGPLLVTLFAGLLRFWNLGSPKAVIFDETYYAKDAWALVHRGFEVNWDKNVNDLILSQNGNVPIPTDAAYVVHPPVGKYVIGLGELMFGFNPFGWRFMTALLGTLSVLLLCRIGRRLFRSTFLGCLAGALMAVDGLHFVMSRTALLDGVLMFFVLAAFGCLLVDRDRARAKLAAALPVDADGRVRPHAHTAEHTRIGLRPWRIAAGLMLGLAIGTKWNGLYILAAFCVMAVLWDVGARKVAGARHPYKAVLQRDLGWAFLSTVPVAIVTYIASWTGWILSATDGTGGYYRNWAATDGKDSSWAWLFPEWWRSLWHYETQVYEFHVGLSSPHTYQSNPWSWLVLGRPVSYFYESPAPGTDGCPVDAGEKCAREVLALGTPLLWWVACFALLYVLWRWFFRRDWRAGAIACGIVAGYLPWFLYQERTIFFFYAVIFVPFLCLAIAMLIGALVGPPGSTDTRRVAGATGAGVLVLLIAWNFIYFWPIYTGQAIPIDDWRSRMWLDTWV
>NZ_CP053109.1|WP_171134077.1|5570841_5571528_+|response-regulator-transcription-factor
MGVRLMVVDDHRLLAEALASALKLRGHRVLAAAAPAAGAAELVIARAPEVCLWGTATPAEAGAFDPVGRIKRERGQVAVLVLGPVPSPRGIAAAFAAGASGYVRHDERIEGVERAIMKARAGEAAVAPQLLQGAFGELLNPAAQPDDEGQRLLQMLTPREVEVLVRVADGEDTRLIAAGMGIAPSTARTHVQRVLMKLGVGSRLEAAALAARTGLLDRAGPLPGRAEG
>NZ_CP053109.1|WP_171108248.1|5571776_5572097_-|hypothetical-protein
MSEHHEYSERDVQREVTELETKSATAARLFDIRRIIGGLFVVYGVIVTIVGLTDDQAAIDKAEGVNINLWTGLGMLLLGLFFLTWLKLRPTAPPTPPITPEDTDQK
>NZ_CP053109.1|WP_171108249.1|5572118_5573798_-|sodium:solute-symporter-family-protein
MQTPTYLAVELRLPTNWLDYTILGIYFVVVLGVGFAARASVKTSLDFFLSGRSLPAWITGLAFIAANLGATEILGMAANSAQYGVYTTHWYWVGAIPAMVFLGLVMMPFYYGSKVRSVPEFLLLRFDKPAHLLSSILFAFAAVLIAGVNLYALAIVVEALLGWPEWVAIVVAGYFVLAYITLGGLSSAIYNEVLQFFVILAALIPLTILALKKAGGWDGLSDTLTAGRGENFMTAWGGTGIGDANPLGANWLTIVLGLGFVLSFGYWTTNFAEVQRALSARNLSAAQRTPLIAAFPKIFIVFLVMIPGLVAAALVPQFGTPESGYQYNDAIPYLMQDLLPNGVLGIAVTGLLAAFMAGMAANVSAFNTVFTNDIWARYTVRGRDDSYYVRFGRIITAVGVLASIGTAFLASAFSNIMAYLQTLFSFFNVPMFVVFIIGMFWKRASMKSGFWGLLAGTTAAMVNYFVIYREGIIDIPSDQGANFVSAIAGFVAGAVVMVAVSLFTAPKPMEDLQGLVYGTRSPGMAEPPAKGDEAWYRKPALLGWGAVILAAACYIPFSF
>NZ_CP053109.1|WP_171108251.1|5573975_5575037_+|galactose-1-phosphate-uridylyltransferase
MKKTSTRLADGRELIYYDLRDDAVRDAADRRPLERTVTTSEIRHDELLGDAVAIASHRQGRTYHPPADECPLCPSQGERLSEIPDSSYDVVVFENRFPSLAGDSGRCEVVCFTSDHTASFADLSEEQVQLVLDAWTDRTSELSHLPSVQQVFCFENRGAEIGVTLGHPHGQIYAYPFTTPRTALMLRSLAAHKDATGGENLFDAVLERELAGERVVLEGEHWVAFVPYAAHWPYEVHLYPRRRVPDLLALDEGARSEFPQVYLELLRRFDRIFGEGEPPTPYIAAWHQAPFGQLEDFEGVSRDDFALHLELFTIRRTSGKLKFLAGSESGMSVFINDVPPERAAERLREVASS
>NZ_CP053109.1|WP_171108253.1|5575033_5575996_+|UDP-glucose-4-epimerase-GalE
MSGKYLVTGGAGYVGSVVAQHLLEAGHEVVVLDNLSTGFREGVPSGASFIEGDIRDAAKWLDSSYDAVLHFAASSQVGESVVRPEKYWDNNVGGTMALLAAMRAAGVRKLVFSSTAATYGEPEQVPIVESAPTAPTNPYGASKLAVDHMITGEAKAHGLGAVSLRYFNVAGAYGEFGERHDPESHLIPLVLQVAQGRRDAISVYGDDYPTPDGTCIRDYIHVADLAEAHLLAVRGAVPGEHLICNLGNGNGFSVREVIETVRQVTGHPIPEVAAPRRGGDPAVLVASAQTARERLGWNPSRADLAGIVADAWEFAQRRGK
>NZ_CP053109.1|WP_171108256.1|5576023_5577196_+|galactokinase
MSEAVAEAVAERFKELYGADPQGVWAAPGRVNLIGEHTDYNDGFVMPFALPHTAVAAVSRRDDGVLRLHSADIEGDAGGVVELRVDALEPESDRNWTAYPAGVVWALRAAGHEVSGADIHLASTVPAGAGLSSSAALEVVVALALNDLHDLGLKGWQLARLCQRAENVYVGAPVGIMDQTASACCTAGHALFLDTRDLSQRQIPFDLAAAGMRLLVVDTRVKHEHSTGEYGKRRAGCEKGAALLGVDALRDIPYAELDAALERLGDDAEVRRLVRHVVTEDERVERVVSLLESGGTRAIGPVLTEGHASLRDDFRISCPELDLVVDSALSAGALGARMTGGGFGGSAIVLAEVTDVDTITKAVQEAFAAAGFTTPRVFEAVPSAGARRVR
>NZ_CP053109.1|WP_171108258.1|5577204_5577666_-|GNAT-family-N-acetyltransferase
MVSRMFRIETEVDRTRRDLLRSRLRDTNTAASPVLRALRGTPAERQAPLHIWALDATDDLAGGLVGHTWTTWLHVTYLWVGERHRGTGLGSHLLAEAERIARAERGCTAARLETWDFQAPGFYRRQGYEVVCAIPDYPPGLTEFTLTKRLRTN
>NZ_CP053109.1|WP_171108260.1|5577963_5578737_+|response-regulator-transcription-factor
MVRIRVLVVDDHRIFAESLAAALAAEPDVEVSAAGSGPAALRSLERAAAEGRRFDVLLVDADLGGNVPGIRPAVPVQEGGVDGVVDGISLVAGVRSAQPGVRVVVLAEKDDPRRAALALQAGASGWVAKDCSLSRLLTVIRGVLRDETHLPPALLTGVLRELTAARRHRTESERLVESLTPREREVLRCMVAGLGRKAVAERLYLSPHTVRTHMQNVLGKLGVHSTLAAVALARRAGVGPADLGPTGRLTPEESNSA
>NZ_CP053109.1|WP_171108262.1|5578831_5579329_-|MarR-family-transcriptional-regulator-TamR
MEDEVDRLVAAWRRERPDLDVEPLEVLSRVSRLARHLDRARRLAFSEHNLEPWEFDVLTALRRAGTPYQLSPGQLLTQTLVTSGTMTNRIDRLAKKGLVERLPDPSDRRGVLVRLTDEGRDRADQALAGLLDQERAILAELSRAQRIELAALLRQLTAPFDNIPG
>NZ_CP053109.1|WP_171108264.1|5579401_5580202_+|trans-aconitate-2-methyltransferase
MADPTWDPAQYLRHAGHRARPFTDLLAQVPDLPTDPPRIADLGCGPGNLTALLAARWPTADITGYDNSPEMLGRARAEHADPGRLDFAHADLRGWAPSEPYDLIFSNATLQWVPGHADRFADWIGGLVPGGTFAFQVPGNFDAPSHRLMRELAGSPRWRDRLADTLRHADAVLTPEAYLERLTGLGCAADVWESTYIHLLTGEDPVLDWVKGTGLRPVLTALADDPEAARAFEDEYRAALREAYPPGRHGTPFPFRRVFAVARKEA

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Crispr_ID: NZ_CP053109_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053109_8

5723333-5723483

Orphan

Consensus_repeat	Method
GGCCCGCCAGACGGACCTGCCGCCCGCGCGGATCGGGCCCGCCAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP053109_8

>merge|NZ_CP053109|8|5723333-5723483|CRISPRCasFinder
GGCGTAACGGCCTGTAGACGCGCCCGCGCGGATCAGGCCCGCCAGACAGGACCCGCCGCCCGCGCCGATCAGGCCCGCCAGACGGACCTGCCGCCCGCGCGGATCGGGCCCGCCAGACGGACCTGCCGCCCGCGCGGATCGGGCCCGCCAG

>NZ_CP053109|8|6|5723333-5723483|CRISPRCasFinder
GGCGTAACGGCCTGTAGACGCGCCCGCGCGGATCAGGCCCGCCAG	ACAGGACCCGCCGCCCGCGCCGATCAGGCCCGCCAGACGGACCTGCCGCCCGCGCGGATCG
GGCCCGCCAGACGGACCTGCCGCCCGCGCGGATCGGGCCCGCCAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053109.1\|WP_171114186.1\|5740141_5741329_-\|DUF4350-domain-containing-protein	unknown	unknown	gnl\|CDD\|379527
NZ_CP053109.1\|WP_171111420.1\|5719521_5719971_-\|metallopeptidase-family-protein	unknown	unknown	gnl\|CDD\|240574
NZ_CP053109.1\|WP_171108455.1\|5709291_5710296_-\|DNA-3-methyladenine-glycosylase-2-family-protein	unknown	unknown	gnl\|CDD\|223200
NZ_CP053109.1\|WP_171108476.1\|5727548_5729006_+\|adenosylhomocysteinase	unknown	unknown	gnl\|CDD\|377487
NZ_CP053109.1\|WP_171108466.1\|5717999_5719460_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377520
NZ_CP053109.1\|WP_171108461.1\|5712698_5713193_-\|cysteine-dioxygenase-family-protein	unknown	unknown	gnl\|CDD\|380416
NZ_CP053109.1\|WP_003975777.1\|5713868_5714132_+\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NZ_CP053109.1\|WP_171108468.1\|5721595_5722960_+\|phosphomannomutase/phosphoglucomutase	unknown	unknown	gnl\|CDD\|236557
NZ_CP053109.1\|WP_171108479.1\|5729940_5730942_-\|RDD-family-protein	unknown	unknown	gnl\|CDD\|224628
NZ_CP053109.1\|WP_171108470.1\|5723571_5724702_+\|mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|378434
NZ_CP053109.1\|WP_171108472.1\|5724862_5726014_+\|mannose-6-phosphate-isomerase,-class-I	unknown	unknown	gnl\|CDD\|380414
NZ_CP053109.1\|WP_171108457.1\|5710355_5711651_-\|coenzyme-F420-0:L-glutamate-ligase	unknown	unknown	gnl\|CDD\|183957
NZ_CP053109.1\|WP_171108474.1\|5726146_5727124_+\|cation-diffusion-facilitator-family-transporter	unknown	unknown	gnl\|CDD\|223131
NZ_CP053109.1\|WP_171108481.1\|5731072_5732080_+\|stage-II-sporulation-protein-M	unknown	unknown	gnl\|CDD\|376676
NZ_CP053109.1\|WP_171114187.1\|5737842_5739153_-\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NZ_CP053109.1\|WP_171108464.1\|5714295_5718003_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|224137
NZ_CP053109.1\|WP_171108459.1\|5711647_5712607_-\|2-phospho-L-lactate-transferase	unknown	unknown	gnl\|CDD\|237443
NZ_CP053109.1\|WP_171118769.1\|5739152_5740142_-\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NZ_CP053109.1\|WP_053760356.1\|5720265_5720688_+\|DUF3499-domain-containing-protein	unknown	unknown	gnl\|CDD\|378788
NZ_CP053109.1\|WP_171108477.1\|5729195_5729810_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP053109.1\|WP_171114186.1\|5740141_5741329_-\|DUF4350-domain-containing-protein	gnl\|CDD\|379527	pfam14258, DUF4350, Domain of unknown function (DUF4350). This domain family is found in bacteria, archaea and eukaryotes, and is approximately 70 amino acids in length.	1.00514e-07
NZ_CP053109.1\|WP_171111420.1\|5719521_5719971_-\|metallopeptidase-family-protein	gnl\|CDD\|240574	cd12954, MMP_TTHA0227_like_1, Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria. The subfamily includes some uncharacterized bacterial proteins which show high sequence similarity with Thermus thermophilus hypothetical protein TTHA0227. However, they do not contain the conserved HExxH (x could be any amino acid) motif. They may not have any zinc metallo-peptidase activity.	1.99729e-26
NZ_CP053109.1\|WP_171108455.1\|5709291_5710296_-\|DNA-3-methyladenine-glycosylase-2-family-protein	gnl\|CDD\|223200	COG0122, AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair].	6.40082e-26
NZ_CP053109.1\|WP_171108476.1\|5727548_5729006_+\|adenosylhomocysteinase	gnl\|CDD\|377487	pfam05221, AdoHcyase, S-adenosyl-L-homocysteine hydrolase.	0
NZ_CP053109.1\|WP_171108466.1\|5717999_5719460_+\|hypothetical-protein	gnl\|CDD\|377520	pfam05506, DUF756, Domain of unknown function (DUF756). This domain is found, normally as a tandem repeat, at the C-terminus of bacterial phospholipase C proteins.	0.000674063
NZ_CP053109.1\|WP_171108461.1\|5712698_5713193_-\|cysteine-dioxygenase-family-protein	gnl\|CDD\|380416	cd10548, cupin_CDO, cysteine dioxygenase, cupin domain. This family contains cysteine dioxygenase (CDO; EC 1.13.11.20), which catalyzes the conversion of cysteine to cysteine sulfinic acid, the first step in the biosynthesis of essential oxidized cysteine metabolites such as sulfate, hypotaurine, and taurine. CDO also plays an important role in the regulation of intracellular cysteine levels in mammals; CDO expression is altered in cancer cells, and abnormal or deficient CDO activity has been linked to Parkinson's disease, Alzheimer's disease, and rheumatoid arthritis. CDO is an iron-dependent thiol dioxygenase that uses molecular oxygen to oxidize the sulfhydryl group of cysteine to generate cysteine sulfinic acid. The CDO active site contains an amino acid-derived cofactor. These enzymes are found in prokaryotes as well as eukaryotes and belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.79047e-23
NZ_CP053109.1\|WP_003975777.1\|5713868_5714132_+\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	1.95518e-28
NZ_CP053109.1\|WP_171108468.1\|5721595_5722960_+\|phosphomannomutase/phosphoglucomutase	gnl\|CDD\|236557	PRK09542, manB, phosphomannomutase/phosphoglucomutase; Reviewed.	0
NZ_CP053109.1\|WP_171108479.1\|5729940_5730942_-\|RDD-family-protein	gnl\|CDD\|224628	COG1714, COG1714, Predicted membrane protein/domain [Function unknown].	7.74315e-21
NZ_CP053109.1\|WP_171108470.1\|5723571_5724702_+\|mannose-6-phosphate-isomerase	gnl\|CDD\|378434	pfam10432, bact-PGI_C, Bacterial phospho-glucose isomerase C-terminal SIS domain. This is the C-terminal SIS domain of a bacterial phospho-glucose isomerase EC:5.3.1.9 protein which is similar to eukaryote homologs to the extent that the sequence includes the cluster of threonines and serines that forms the sugar phosphate-binding site in conventional PGI. This domain contributes a good proportion of the active catalytic site residues. This PGI uses the same catalytic mechanisms for both glucose ring-opening and isomerisation for the interconversion of glucose 6-phosphate to fructose 6-phosphate. It is associated with family SIS, pfam01380.	4.14115e-18
NZ_CP053109.1\|WP_171108472.1\|5724862_5726014_+\|mannose-6-phosphate-isomerase,-class-I	gnl\|CDD\|380414	cd07011, cupin_PMI_type_I_N, type I phosphomannose isomerase in eukaryotes and bacteria, N-terminal cupin domain. This subfamily contains type I phosphomannose isomerase (PMI; E.C. 5.3.1.8; also known as mannose-6-phosphate isomerase) found in eukaryotes and some bacteria such as Salmonella enterica. PMI catalyzes the reversible isomerization of fructose-6-phosphate (F6P) and mannose-6-phosphate (M6P), the first committed step in the synthesis of mannosylated glycoproteins. The active site, located within the N-terminal jelly roll-like beta-barrel cupin fold, contains a single essential zinc atom and forms a deep, open cavity large enough to contain M6P or F6P. PMI type I also has a C-terminal beta-barrel fold which has diverged considerably from the N-terminal domain and is not included here. This subfamily contains an alpha helical domain that is found in eukaryotic and some prokaryotic PMIs but is not present in their archaeal counterparts. F6P is a substrate for glycolysis and gluconeogenesis, while M6P is a substrate for production of activated mannose donor guanosine 5'-diphosphate D-mannose, an important precursor of mannosylated biomolecules such as glycoproteins, bacterial exopolysaccharides and fungal cell wall components. PMI is also essential for survival, virulence and possibly pathogenicity of some bacteria and protozoan parasites, as well as for cell wall integrity of certain yeasts. Thus, PMI is a potential target against fungal infections causing serious illness or death.	1.55986e-108
NZ_CP053109.1\|WP_171108457.1\|5710355_5711651_-\|coenzyme-F420-0:L-glutamate-ligase	gnl\|CDD\|183957	PRK13294, PRK13294, F420-0--gamma-glutamyl ligase; Provisional.	0
NZ_CP053109.1\|WP_171108474.1\|5726146_5727124_+\|cation-diffusion-facilitator-family-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	1.76006e-38
NZ_CP053109.1\|WP_171108481.1\|5731072_5732080_+\|stage-II-sporulation-protein-M	gnl\|CDD\|376676	pfam01944, SpoIIM, Stage II sporulation protein M. SpoIIM is on e of four stage II sporulation proteins that is necessary for the forespore inside the mother-cell to be properly internalized through the breakdown of peptidoglycans trapped between the membranes of the septum separating the forespore and the mother-cell. The four proteins working in sequence are SpoIIB, pfam05036, SpoIIM, SpoIIP, pfam07454, and finally SpoIID, pfam08486. D, M and P are in a complex with each other and the complex assembles in a hierarchical manner such that M, which serves as a membrane anchor, recruits P to the septum and P, in turn, recruits D to the septum.	1.1291e-42
NZ_CP053109.1\|WP_171114187.1\|5737842_5739153_-\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	1.1116e-47
NZ_CP053109.1\|WP_171108464.1\|5714295_5718003_+\|glycosyltransferase	gnl\|CDD\|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	2.65291e-32
NZ_CP053109.1\|WP_171108459.1\|5711647_5712607_-\|2-phospho-L-lactate-transferase	gnl\|CDD\|237443	PRK13606, PRK13606, LPPG:FO 2-phospho-L-lactate transferase; Provisional.	1.63213e-174
NZ_CP053109.1\|WP_171118769.1\|5739152_5740142_-\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	2.34723e-99
NZ_CP053109.1\|WP_053760356.1\|5720265_5720688_+\|DUF3499-domain-containing-protein	gnl\|CDD\|378788	pfam12005, DUF3499, Protein of unknown function (DUF3499). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 125 to 163 amino acids in length.	5.13242e-58

>NZ_CP053109.1|WP_171108468.1|5721595_5722960_+|phosphomannomutase/phosphoglucomutase
MAADLSQIVKAYDVRGVVPDQWDEPLAELFGAAFAQVTRADAIVIGHDMRPSSPGLSRAFARGAAARGVDVTEIGLCSTDQLYYASGVLNLPGAMFTASHNPAKYNGIKMCRAGAAPVGQDTGLAEIRELVERWSESGAPEPAAKQGTITQRDTLEDYAAHLRSLVDLTSIRPLKVVVDAGNGMGGHTVPTVFAGLPLDLVPMYFELDGTFPNHEANPLDPANIVDLQQRVRTEGADLGIAFDGDADRCFVVDENGDPVSPSAITALVASRELAKHGGEGVVIHNLITSWTVPEVVKENGGTPIRTRVGHSFIKAEMARTGAIFGGEHSAHYYFRDFWNADTGMLAALHVLAALGGQEGPLSSLVAQYDRYAGSGEINSTVDDQQDRIAALKSAYEGREGITLDELDGLTVTADDWWFNVRPSNTEPLLRLNAEARDEATMAKVRDEVLAIIRG
>NZ_CP053109.1|WP_053760356.1|5720265_5720688_+|DUF3499-domain-containing-protein
MESRRGPLKSAVPSNVVSPVRRCSRTACGRPAVATLTYVYADSTAVLGPLATYAEPHCYDLCAEHSERLTAPRGWEVVRLLDGSAPARPSGDDLEALANAVREAARPQERAAQAGGGGRAADPMEVARRGHLRVLRSPDN
>NZ_CP053109.1|WP_171111420.1|5719521_5719971_-|metallopeptidase-family-protein
MDNRVPPRAAGPGPRRRDRHGRGMRGPIAPPQVPLAASRAEAFADLVQDSVERLERRWPQLADIDFLVLEVPRLDGPGRAWNDEAVPLGGTIPAREGRPARVVVYRRPVEIRTKGRDERAALVHEVVVEQVAELLGLTPETVDPRYGED
>NZ_CP053109.1|WP_171108466.1|5717999_5719460_+|hypothetical-protein
MNRTTVSLIAGVAALAAVTGFAVLSAPEATGTDTAKAAAQLPVERTSLVCPAPSTSDLAETTYSSFTPVTEGTGNEGKGELKSAGGGKDGKPVLEPKEPGSPVSGESSGGEAPALMGTAEGKFAPGWTVQETTEVTAGAGRGLLGVNCSAPDTEFWFPGASTSDGRTDYVHLTNPDDSAAVVDIELYGKDGALESTVGEGITVAPRSSEPILLSTLTGAKETDLTVHVNVRSGRVGAAVQALDDKAGGDWLEAAAEPAGSLVVPGIPKDATAVRLVAFTPGDADADLKVRLASPTGLITPAGHETLHVKPGVTTAIDLGDVTRGEPGSLVLTPTDRAAPVVAAVQVVRGKGDSQETAFIPAARAVDTRASSAGNTEKGVTLSLAAPGEAAQVKVTASAGTEGGTAVSKTYSVKAGTTQDVEVPVPSGLKGTYALTVEPVSGGPVYASRTLIASQDGVPAFTIQTLPDDRGTVAVPEAEQDLSVLQK
>NZ_CP053109.1|WP_171108464.1|5714295_5718003_+|glycosyltransferase
MSVHSHTAAQHDAAATPEFPRHVVTAVLVSHDGARWLPDALAGLLGQERPVQYVMAADTGSADDSAQLVTEALGPDRVLHLARRTGFGQAVEEVNRTAPVLTPEDLPYLRRPSGWDPVTRSWRDDAYDMPELPHGEPVQWLWLLHDDCAPEPDALAELLRVVENELELGRDDVAVVGPKLRGWYDRRQLLEVGVTIANSGRRWTGLDRREQDQGQHDHVRPVLSVSTAGMLIRRDVFEQLGGFDRRLPLMRDDVDLCWRAHAAGHRVLVAPEAVVRHAEAASRERRTVDCAGRTAASPHKVDKAGAAYTLLVNARTATLPWVLLRLVLGTLLRTVAYLVGKVPGQAVDEIRGLLGVLLRPERIVAGRRRRGRPVVDKSELRPLFPPPGATVRATVEQAAGSVVGRSDPEVTSGAGRHGGAVESGPGGDDADFLEIEQFARLKRIARNPGPMLFLVLLFVSLVACRELLGGGSLAGGALLPAPADSGELWSRYLDSWHPVGAGGNAAAPPYLALVAMLASALFGSTGLVVTVLLVCSVPLAGFTAYFASRPLVESRLLRAWAAVVYAFLPAATGALAGGRLGTAVLAVLLPLLARAAVAASGLANPSGARGSWRATWAYALLLTVTTAFTPIVWPVALVLGIGLLAVRRGDITAYGLRFLTQLGTPLLLLAPWSLSLLPFGFFREAGLEYGDSAASALDLLGASPGGPGTVSGLMLFGIVLAALAALMRHERQSGIWTAWTAALVGLVFAVLSNSSAWAGPATLVYGIALLTAAVMGAEGARARVAEQSFGWRQPVAALIAFASAAGPLLIAAGWMIRGADGPVERRDPVQVPAFVAEESSTRDQARTLVLDSDSTAHVGYTLVRGSGARLGDAELAAADGGNAALDKVVANLVAGSGADQADQLGDFAVRYVLVHKGAPREVSRVLDATPGLSRLSQQDGSALWRVDRQVARAVIVPASGSGDPQPVAAGPVEIHTKVPDGADGRILRLADTASDGWTATLDGKPLTRTTVDGWAQGFELPTGGGTLDVTYDDPIGHTAWLWAQGFLAVVLVVLALPGRRRDVDDDLPEEPAIPAQAVAGEGRRARRLRAQAEAEEAARGEEFPSPPQEETPVSVPQQQPYDMGVPPGEDVRAWGRDTASYAGAEYGTYGGEQYQGAGQQYAAGGYGQPYQNDQYQADPYQGGQYDPYAYGGSAQQGAYEQTYDQYPQGYDATYDPTQQQGPHGSGSERPDGSQQ
>NZ_CP053109.1|WP_003975777.1|5713868_5714132_+|WhiB-family-transcriptional-regulator
MTELVQQLLVDDADEELGWQERALCAQTDPESFFPEKGGSTREAKKVCLACEVRSECLEYALANDERFGIWGGLSERERRRLKKAAV
>NZ_CP053109.1|WP_171108461.1|5712698_5713193_-|cysteine-dioxygenase-family-protein
MNSDSDLQIAGDILEVPHLLQAPREHPATVAEFVGLARSIAADRSQWEHLVQYDATSRWYHRLRTGPGYEVWLLSWVPGQGSGLHDHGPSSGVLTVLDGTLTERTRRGTRALEPGAQRVFAPGYVHEVVNDALEAAVSLHIYYPGLTQMPMHTTPHCEARAVTA
>NZ_CP053109.1|WP_171108459.1|5711647_5712607_-|2-phospho-L-lactate-transferase
MRIVVLAGGIGGARFLRGLKRAVPDADITVIGNTGDDIHLFGLKVCPDLDTVMYTLGGGINEEQGWGRADETFHLKEELAAYGVGPEWFGLGDRDFATHIVRTQMIGAGYPLSAVTEALCDRWQPGVRLIPMTDDRVETHVAVELDGERKAIHFQEYWVRLRASVPAEAVVPVGAEQAKPAPGVLEAIAQADVILFPPSNPVVSVGTILAVPGIREAIADAGVPVVGLSPIVGDAPVRGMADKVLAAVGVEATAAAVAEHYGSGLLDGWLVDTVDASAVERVEGAGIRCRAVPLLMTDEQAAAQMARDALALAEEVRAA
>NZ_CP053109.1|WP_171108457.1|5710355_5711651_-|coenzyme-F420-0:L-glutamate-ligase
MTGYRVWAIPGLPEVAPGDDLAKLIAAAEPGLADGDVLLVTSKIVSKAEGRIVQADDREAAIDAETVRVVARRGPLRIVENRQGLIMAAAGVDASNTPSGTVLLLPEDPDASARTIRNGLRDTLGVDVGVIVTDTFGRPWRSGLTDVAIGAAGIRVLDDLRGGTDAYGNPLSATVVATADELAAAGDLVKGKAAGLPVAVVRGLPHTVAEEDGEGARALVRGARDDMFRLGTSEAVREAVTQRRTVRSFTDEPVDPGAVRRAVAAAVTAPAPHHTTPWRFVLLESPEARTELLDAMRDAWIADLRQDGKTEESIAKRIRRGDVLRNAPYLVVPCLVMDGSHTYGDPRRDGAEREMFVVAAGAGVQNFLVALAGERLGSAWVSSTMFCRDVVREVLRLPADWDPMGAVAVGHPAEEPRPRPERDAGTFIEVR
>NZ_CP053109.1|WP_171108455.1|5709291_5710296_-|DNA-3-methyladenine-glycosylase-2-family-protein
MAGRFAPRPTRTTVRGGEVGVPAGVPRQVARTAGRIRTWVPDGPLDLGLVLGPLRRGPGDPTFRTTPDGSVWRACLTPAGPGTLRVSAQGTQVRGEAWGPGADWLLDQLPDLLGASDDPSLFAPRHRIVALARHRRPGLRLTRSGLVLESLIPSILEQKVTTDEAYRAWRLLVRKFGEPAPGPVPGQMYVMPPPRTWALIPSWEWHRAGVDDKRASTILRAVRVAARLEQTVGMQPPAARARLELVPGVGPWTSAETVQRSHGAPDEVTVGDLHLPGIVGWALAGDRDADDSVMLSLLEPYAGQRHRAARLILLSGRVPPRRAPRMPRGDIGRL
>NZ_CP053109.1|WP_171108470.1|5723571_5724702_+|mannose-6-phosphate-isomerase
MLDESLLDSPDGLAEADQRGLLRGAAEAGARVRTAARHATEAGVGELKPDGRPRAVLIAGPGAAATHAADLLGTLAGPGSPVTRLAPTGVAPAAGALRWELPGWAGSVDLLLITTPDGTEPGLSLLAEQAYRRGCAVAAVAPAGTPIADAVSGAAHGLFVPMATAPYEQDEPLAASAPGVLWALLTPLLALLDRIGLLTAAPDALEKVADRLDHIAERCGPAIATYSNPAKTLAAELADALPVIWTEGTSAGPAGRRFAAALAELSGQPAVVAELPEALAAHSALLAGPLAARANPDDFFRDRVEEPPALHARVVLLRDRPIGGLTAAPAARDLALSHDTPISELEPDPGGELETLAELIAITDFAAVYLALASRA
>NZ_CP053109.1|WP_171108472.1|5724862_5726014_+|mannose-6-phosphate-isomerase,-class-I
MDRLDNTIRPYAWGSTTAIPQLLGVEPTGEPQAEMWMGAHPGAPSHTDRGTLVDVIAAAPEKELGAAAVTKFGPSLPFLLKILAAGAPLSLQVHPNLEQAQEGYEEEERRGVPVDAPHRNYKDANHKPELICALTEFDGLCGFRDPRQAADLLDGLGVDSLKPYVDLLRAHPEDAALREVLTAVLTADPEEMARTVAEATAACARLGGAYTAYADLAHHYPGDPGVIAAMLLHHVRLQPGEALYLGAGIPHAYLNGLGVEIMANSDNVLRCGLTPKHVDVPELLRIVRFQPSDPGVLRPEASPDGEEVYETPIDEFRLSRYVLPEGGTTHDLTRATPQILLCTAGSVRTGEHELRPGQSVFVPAGEKAEVSGTGTLFRATVVA
>NZ_CP053109.1|WP_171108474.1|5726146_5727124_+|cation-diffusion-facilitator-family-transporter
MSASGGTKAIVAALVANLAIAVAKFVAFLFSGSSSMLAESVHSVADSGNQGLLLLGGRKAQREATPQHPFGYGRERYIYAFLVSIVLFSVGGMFAIYEGYEKIKHPHEIEHWYWPVGVLVFAIIAETFSFRTAIKESNVLRGRKSWKEFVRHAKAPELPVVLLEDLGALVGLILALGGVGLALLTGDSVWDGIGTLCIGVLLILIALVLAVETKSLLLGEAAGVEEVKKIEASIVDGDNVTGIIHMRTLHLGPEELLVAAKIAVRHDGTATEIASAIDAAEARVRESVPIARVIYLEPDIYSEAEAAKGPDREASPGGPSHTTGH
>NZ_CP053109.1|WP_171108476.1|5727548_5729006_+|adenosylhomocysteinase
MTTVENRQDFKVADLSLAEFGRKEITLAEHEMPGLMAIRKEYAEAQPLKGARITGSLHMTVQTAVLIETLVALGAQVRWASCNIFSTQDHAAAAIAVGPNGTPDNPQGIPVFAWKGETLQEYWWCTEQALTWPNTPTGGPNMILDDGGDATLLVHKGVEYEKDGKVPSPDTAESEEHRVILELLTRTVSETPQKWTQLASEIRGVTEETTTGVHRLYEMQREGTLLFPAINVNDAVTKSKFDNKYGCRHSLVDGINRATDTLIGGKTAVVCGYGDVGKGCAESLRGQGARVIVTEIDPICALQAAMDGYQVTTLDEVVDKADIFITTTGNKDIIMASDMAKMKHQAIVGNIGHFDNEIDMAGLAKVPGIVKDEIKPQVHTWTFPDGKKIIVLSEGRLLNLGNATGHPSFVMSNSFADQTLAQIELFTKPDEYPTDVYVLPKHLDEKVARLHLDALGVKLTTLRPEQAEYIGVKVEGPFKPDHYRY
>NZ_CP053109.1|WP_171108477.1|5729195_5729810_+|hypothetical-protein
MPRGRYSLHDPHDHTLLAEEHFHCAPGPSGWRYVSQLTTPSGDHRGSVDLALDELGRPIRLELHAAGWQVRGAALDGVTWVRTDPTGTDATEGNVRAHAFTGTSPAFLIATTRLLRLTPSGSATRVRLVAFTDPVLAPRTVDQSWALLKREAHGTDNGPLTVDEYQVTALDTGEQHLLHIAGDVVLAAPGIELEDLDSPPSVFP
>NZ_CP053109.1|WP_171108479.1|5729940_5730942_-|RDD-family-protein
MSELVTGEAVALELRPARLPSRALAVLLDLIVAFAAYMIVTMVLVISTASLDEAAQIAISIATFLLVLVGAPIAVETLSHGRSLGKMAFGLRVVRDDGGPIRFRHALVRGAIGVVEILLTLGVIACIASLVSERGRRLGDVFAGTLVVRERVPAARARFVPPPPPWLAGRFSGLDLSAVPDGLWLAIRQYLTRMQQLDPQVGGAMAERLAADLAERTGTPVPQGIPPAAYLAAVVQERQAREIRRAYADGAAAGGPGRDGQHGQYGRSTAPGAHSPVPAPPPAEHFPAPAQPGHETAQPGRRPEGPAQPPPGPQQDGQSPDRDRPATGFVPPA
>NZ_CP053109.1|WP_171108481.1|5731072_5732080_+|stage-II-sporulation-protein-M
MDLDVFISAHRAEWDRLEDLLRRQRRLTGAETDELVALYQRTATHLSLIQSSAPDPQLTGRLSQLVARARSAVTGTRRASWRDVTRFLAYGFPAAVYRSRHWWVPTALLSTLVAALLGWWIGTHPEVQATIAAPSELRELTRPGGEYESYYSTHPAASFAARVWTNNAQAAAMCLVFGVFLGLPVLWILFQNMLNLGIGFGLMSSAGRLDTFLGLVLPHGLLELTAVFVAAGTGLRLGWTVIDPGPRTRRKALAEEGRAALGMAIGLALVLFIAGAIEGFVTPSGLPTWARIGIGIAAELAFLAYVYVLGRRAARGGETGDVEASERSATVPTAA
>NZ_CP053109.1|WP_171114187.1|5737842_5739153_-|DUF58-domain-containing-protein
MALTGRAALLAALGSLPVGLWDPSWTGILAVNSPLAIACACDFALAAPVRHLGLTRSGDTSVRLGETADVTLTITNPSRRPLRAHLRDAWPPSSWQPGTEVMASRHRLTVPAGERRRITTRLRPTRRGDRQADRVTIRSYGPMGLFARQGTHKVPWTVRVLPPFTSRKHLPSKLARLRELDGRTSVLQRGEGTEFDSLREYVPGDDTRSIDWRATARQSSVAVRTWRPERDRHILLVLDTGRTSAGRVGDAPRLDAAMDAALLLAALASRAGDRVDLLAYDRRVRALVQGRTAGDVLPSLVNAMATVEPELIETDARGLTATALRTAPRRSLIVLLTTLDAAPVEEGLLPVLPQLTQRHTVLVASVADPHIARMATSRGNTESVYDAAAAAQAQSERHRTAEQLRRHGVTVVDATPDELAPTLADAYLALKTTGRL
>NZ_CP053109.1|WP_171118769.1|5739152_5740142_-|MoxR-family-ATPase
MDPTTDNAGQTGDPGNARAALEALRAEIAKAVVGQDPAVTGLVVALLCRGHVLLEGVPGVAKTLLVRALASALELDTKRVQFTPDLMPSDVTGSLVYDARTAEFSFQPGPVFTNLLLADEINRTPPKTQSSLLEAMEERQVTVDGIPRPLPEPFLVAATQNPVEYEGTYPLPEAQLDRFLLKLTIPLPSRQDEIDVLTRHAEGFNPRDLRAAGVRPVAGRAVLDAARAAVAKTTVSPDITAYVVDICRATRESPSLTLGVSPRGATALLATSRAWAWLTGRDYVTPDDVKALALPTLRHRVQLRPEAEMEGVTADSVINAILAHVPVPR
>NZ_CP053109.1|WP_171114186.1|5740141_5741329_-|DUF4350-domain-containing-protein
MTPEATLPSTSASRTPRQVWTRARGIALALVLLLAGAIVIALVRSDAQHGSLDPRSTAPQGSRAVAELLADRGVSTRVVTTLEEARAAAAPDTTLLVAVPDLLTDRQKSLLRSTAAASGGRTILVAAGSSSVEQLAPGVHADPATSLQSTLEPNCDFPAALRAGAADTGGLRYTTTHLGADECYPSQRLASLIRVPEATGGDTVVLGAPDILYNDRLDKQGNASLALQLLGSRPHLVWYLPSLSDATTPDDERSFFDLIPSGWLWGTLQLFIAAALAALWRARRLGPLVPEKLPVAIRASETVEGRARLYRKAAARDRAATALRSTTRTRLAPLVGVPVAQAHTPEALLPALSTHLRGDGQSLHTLLFGPPPSDDAALIALADHLDALEREVRRP

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Crispr_ID: NZ_CP053109_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053109_9

6103253-6103445

Orphan

Consensus_repeat	Method
CGCCCACGGAGCCGCCGACGGCA	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP053109_9

>merge|NZ_CP053109|9|6103253-6103445|CRISPRCasFinder
CGGCTACGGTGACGACGGCGGCTACGGTGACGACGGCGGCTACGGTGACGACTCGTCCACACCGCCCACGGAGCCGCCGACGGCACCGTCCACCACCGCTCCACCGGTGACAAGGACGCCCACGGAGCCGCCGACGTCAGGGCCACACACCACTCCGCCGGCGACAAGGACGCCCATGGAGCCGCCGGCGGCC

>NZ_CP053109|9|7|6103253-6103445|CRISPRCasFinder
CGGCTACGGTGACGACGGCGGCT	ACGGTGACGACGGCGGCTACGGTGACGACTCGTCCACAC
CGCCCACGGAGCCGCCGACGGCA	CCGTCCACCACCGCTCCACCGGTGACAAGGA
CGCCCACGGAGCCGCCGACGTCA	GGGCCACACACCACTCCGCCGGCGACAAGGA
CGCCCATGGAGCCGCCGGCGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053109.1\|WP_171116464.1\|6117143_6117704_+\|tyrosinase-co-factor-protein	unknown	unknown	gnl\|CDD\|368807
NZ_CP053109.1\|WP_171134082.1\|6098556_6098763_+\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NZ_CP053109.1\|WP_171116476.1\|6110021_6110702_-\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|213023
NZ_CP053109.1\|WP_171116469.1\|6113735_6115217_-\|exopolysaccharide-biosynthesis-polyprenyl-glycosylphosphotransferase	unknown	unknown	gnl\|CDD\|274398
NZ_CP053109.1\|WP_171116474.1\|6110772_6112413_-\|murein-biosynthesis-protein-MurJ	unknown	unknown	gnl\|CDD\|240528
NZ_CP053109.1\|WP_171116290.1\|6093365_6095450_+\|ISAzo13-family-transposase	unknown	unknown	gnl\|CDD\|369439
NZ_CP053109.1\|WP_171116466.1\|6115213_6116428_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340837
NZ_CP053109.1\|WP_171116490.1\|6100930_6101242_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171116501.1\|6092111_6092456_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171116492.1\|6100125_6100386_+\|transposase	unknown	unknown	gnl\|CDD\|372671
NZ_CP053109.1\|WP_171116480.1\|6106885_6108151_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379214
NZ_CP053109.1\|WP_171116503.1\|6090149_6091358_-\|S8-family-peptidase	unknown	unknown	gnl\|CDD\|173790
NZ_CP053109.1\|WP_171116488.1\|6101945_6102161_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171116504.1\|6088034_6088250_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171116499.1\|6096521_6096743_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171116478.1\|6108827_6109994_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340836
NZ_CP053109.1\|WP_171116483.1\|6105787_6106987_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226609
NZ_CP053109.1\|WP_171119006.1\|6108147_6108765_-\|lipopolysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|367147
NZ_CP053109.1\|WP_171116472.1\|6112409_6113729_-\|O-antigen-ligase-family-protein	unknown	unknown	gnl\|CDD\|132141
NZ_CP053109.1\|WP_171116496.1\|6096755_6097265_+\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853

Protein	Function_ID	Function_description	E-value
NZ_CP053109.1\|WP_171116464.1\|6117143_6117704_+\|tyrosinase-co-factor-protein	gnl\|CDD\|368807	pfam06236, MelC1, Tyrosinase co-factor MelC1. This family consists of several tyrosinase co-factor MELC1 proteins from a number of Streptomyces species. The melanin operon (melC) of Streptomyces antibioticus contains two genes, melC1 and melC2 (apotyrosinase). It is thought that MelC1 forms a transient binary complex with the downstream apotyrosinase MelC2 to facilitate the incorporation of copper ion and the secretion of tyrosinase indicating that MelC1 is a chaperone for the apotyrosinase MelC2.	2.76811e-22
NZ_CP053109.1\|WP_171134082.1\|6098556_6098763_+\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	1.5112e-07
NZ_CP053109.1\|WP_171116476.1\|6110021_6110702_-\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|213023	cd10918, CE4_NodB_like_5s_6s, Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, hemin storage system HmsF protein in gram-negative species, intercellular adhesion proteins IcaB, and many uncharacterized prokaryotic polysaccharide deacetylases. It also includes a putative polysaccharide deacetylase YxkH encoded by the Bacillus subtilis yxkH gene, which is one of six polysaccharide deacetylase gene homologs present in the Bacillus subtilis genome. Sequence comparison shows all family members contain a conserved domain similar to the catalytic NodB homology domain of rhizobial NodB-like proteins, which consists of a deformed (beta/alpha)8 barrel fold with 6 or 7 strands. However, in this family, most proteins have 5 strands and some have 6 strands. Moreover, long insertions are found in many family members, whose function remains unknown.	2.69964e-53
NZ_CP053109.1\|WP_171116469.1\|6113735_6115217_-\|exopolysaccharide-biosynthesis-polyprenyl-glycosylphosphotransferase	gnl\|CDD\|274398	TIGR03025, EPS_sugtrans, exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase. Members of this family are generally found near other genes involved in the biosynthesis of a variety of exopolysaccharides. These proteins consist of two fused domains, an N-terminal hydrophobic domain of generally low conservation and a highly conserved C-terminal sugar transferase domain (pfam02397). Characterized and partially characterized members of this subfamily include Salmonella WbaP (originally RfbP), E. coli WcaJ, Methylobacillus EpsB, Xanthomonas GumD, Vibrio CpsA, Erwinia AmsG, Group B Streptococcus CpsE (originally CpsD), and Streptococcus suis Cps2E. Each of these is believed to act in transferring the sugar from, for instance, UDP-glucose or UDP-galactose, to a lipid carrier such as undecaprenyl phosphate as the first (priming) step in the synthesis of an oligosaccharide "block". This function is encoded in the C-terminal domain. The liposaccharide is believed to be subsequently transferred through a "flippase" function from the cytoplasmic to the periplasmic face of the inner membrane by the N-terminal domain. Certain closely related transferase enzymes, such as Sinorhizobium ExoY and Lactococcus EpsD, lack the N-terminal domain and are not found by this model.	1.80003e-104
NZ_CP053109.1\|WP_171116480.1\|6106885_6108151_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379214	pfam13480, Acetyltransf_6, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions.	1.36654e-16
NZ_CP053109.1\|WP_171116290.1\|6093365_6095450_+\|ISAzo13-family-transposase	gnl\|CDD\|369439	pfam07592, DDE_Tnp_ISAZ013, Rhodopirellula transposase DDE domain. These transposases are found in the planctomycete Rhodopirellula baltica, the cyanobacterium Nostoc, and the Gram-positive bacterium Streptomyces.	0
NZ_CP053109.1\|WP_171116466.1\|6115213_6116428_-\|glycosyltransferase	gnl\|CDD\|340837	cd03808, GT4_CapM-like, capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.	1.95654e-65
NZ_CP053109.1\|WP_171116492.1\|6100125_6100386_+\|transposase	gnl\|CDD\|372671	pfam13683, rve_3, Integrase core domain.	9.12224e-11
NZ_CP053109.1\|WP_171116474.1\|6110772_6112413_-\|murein-biosynthesis-protein-MurJ	gnl\|CDD\|240528	cd13123, MATE_MurJ_like, MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	1.90107e-76
NZ_CP053109.1\|WP_171116503.1\|6090149_6091358_-\|S8-family-peptidase	gnl\|CDD\|173790	cd04077, Peptidases_S8_PCSK9_ProteinaseK_like, Peptidase S8 family domain in ProteinaseK-like proteins. The peptidase S8 or Subtilase clan of proteases have a Asp/His/Ser catalytic triad that is not homologous to trypsin. This CD contains several members of this clan including: PCSK9 (Proprotein convertase subtilisin/kexin type 9), Proteinase_K, Proteinase_T, and other subtilisin-like serine proteases. PCSK9 posttranslationally regulates hepatic low-density lipoprotein receptors (LDLRs) by binding to LDLRs on the cell surface, leading to their degradation. The binding site of PCSK9 has been localized to the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR. Characterized Proteinases K are secreted endopeptidases with a high degree of sequence conservation. Proteinases K are not substrate-specific and function in a wide variety of species in different pathways. It can hydrolyze keratin and other proteins with subtilisin-like specificity. The number of calcium-binding motifs found in these differ. Proteinase T is a novel proteinase from the fungus Tritirachium album Limber. The amino acid sequence of proteinase T as deduced from the nucleotide sequence is about 56% identical to that of proteinase K.	2.95311e-114
NZ_CP053109.1\|WP_171116478.1\|6108827_6109994_-\|glycosyltransferase	gnl\|CDD\|340836	cd03807, GT4_WbnK-like, Shigella dysenteriae WbnK and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.	1.39137e-90
NZ_CP053109.1\|WP_171116483.1\|6105787_6106987_+\|hypothetical-protein	gnl\|CDD\|226609	COG4124, ManB, Beta-mannanase [Carbohydrate transport and metabolism].	3.13524e-05
NZ_CP053109.1\|WP_171119006.1\|6108147_6108765_-\|lipopolysaccharide-biosynthesis-protein	gnl\|CDD\|367147	pfam02706, Wzz, Chain length determinant protein. This family includes proteins involved in lipopolysaccharide (lps) biosynthesis. This family comprises the whole length of chain length determinant protein (or wzz protein) that confers a modal distribution of chain length on the O-antigen component of lps. This region is also found as part of bacterial tyrosine kinases.	0.0099602
NZ_CP053109.1\|WP_171116472.1\|6112409_6113729_-\|O-antigen-ligase-family-protein	gnl\|CDD\|132141	TIGR03097, PEP_O_lig_1, probable O-glycosylation ligase, exosortase A-associated. These proteins are members of the O-antigen polymerase (wzy) family described by pfam04932. This group is associated with genomes and ususally genomic contexts containing elements of the exosortase/PEP-CTERM protein export system, specificially the type 1 variety of this system described by the Genome Property, GenProp0652.	1.29202e-10
NZ_CP053109.1\|WP_171116496.1\|6096755_6097265_+\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	4.44005e-41

>NZ_CP053109.1|WP_171116488.1|6101945_6102161_+|hypothetical-protein
MRKSMKRGAASTLVAVALLAGSASAASAFGEDDYGNGDSIVIVNVNNNSNTNSNTNTNTATATATVPAPAA
>NZ_CP053109.1|WP_171116490.1|6100930_6101242_+|hypothetical-protein
MRKSMKRGAASTLAAVAILAGSASVASASEGEYQLEGDGPGIVIINDNENTNSNTNTNENTATATATVTLPAPEPAPEPAPAPAAVGAAGSAVAPTLLGVLGL
>NZ_CP053109.1|WP_171116492.1|6100125_6100386_+|transposase
MGATPSMGAVGTSADNAACESFHATLKRETFRGAHYYPGAELSRRTVFRWLTRYNTRRRHSANGHLSPVDYEHQHQQQFDKLTLAS
>NZ_CP053109.1|WP_171134082.1|6098556_6098763_+|IS3-family-transposase
MSEAFNSVLKVECVHRHTFRTRTEARIKIATLITDFYNTGRLHSVCGFKSPIDYERDYRATLAEGLAA
>NZ_CP053109.1|WP_171116496.1|6096755_6097265_+|IS3-family-transposase
MFVELVRRGWRVSVNTVAKLMAELGVAGRRVRRRRSVTRPGKRLAAPDFVKRDFTAEEPDLVWAGDMTEIDTGEGKLYLATVIDLFSRRLLGYAMGTRHDAELVVASLNVAAATRGGDVRGVIMHTDRGSEYCSRKLQRACRKLGITQSMGRVGSCFDGEDGVTAAVVA
>NZ_CP053109.1|WP_171116499.1|6096521_6096743_+|hypothetical-protein
MGEVADADPVVAVGVISSCKAEQKIPYRIACRALGVSESWFYKWRERLPTARETRRQRLAEDIEEIFRGSGGT
>NZ_CP053109.1|WP_171116290.1|6093365_6095450_+|ISAzo13-family-transposase
MSFAADVLDQLALRFQVVLPHLNERQRRLMLAQEARLLGHGGVRAVARVAGVSESTVRNGVFELEAGGDPLPDGAVRRPGGGRKPAEEQDPSLVPALLKLVEPDERGDPMSPLRWTTKSLRNLAEELTRQGHPVSAPTVGRLLKVQGFSLQASAKTLEGKQHPDRDAQFRYINEQVKEHQSSGQPVISIDAKKKEQLGQLPNPGRQWRPAGDPVQVEDHSFYFIGPDVDVAIPFGIYDLAHDSGWVNVGTDHDTSVFAVESIRRWWRARGRMDHPDADRLLITADCGGSNSYRYRLWKAELAAFAAQMGLTVTVCHFPPGTSKWNKVEHRLFSHITMNWRGRPLTSHEVVVNSIAATRTRTGLRVHAELDTGTYPVGISVSREHLRSLPITPHDQHGSWNYTITPAGAASNCAVNTSDRDQSRLRVLAMLADPRLSGMTSSELEALCARLAPAQAAQAEQRKFQQRGGRRLKAPGAHGRPLLSNADRILVTVIYLRRVCSQKVLVDLLAINPVTIGQVIGETRTLIDAQKITVSQTAHYFSSAQELRDWAEGGATTSRMDLSQTLSHPALTGMPRPDFQALIDRITVPYQATIEQRRHRKRGGGRRPGTRGGVFRQKITDADRILATVLSQRNLCDQQTLADLFGVSRGTIRNAIEDVRPLLEQDPYIPTLAERRFTTAADVLASVTRDSETPC
>NZ_CP053109.1|WP_171116501.1|6092111_6092456_+|hypothetical-protein
MPHRMLRSAATALLASAPLVAAVPAQAAPQQVFPCDVSLQKLSNNTTTVISASFTCSQDLSVSVKIAAGDIVFVNVQKAVRTGVQESVTVAVPRTTAEVCATLKAGDQSTEVCS
>NZ_CP053109.1|WP_171116503.1|6090149_6091358_-|S8-family-peptidase
MRETFTVRRRIVAAIATTAATIAIGCGTALPVEAAPAAGRILHENSPNAVDNSYIVVLKESAGFKANSTQGELLAAKYGATVDRTYDAALNGYAVRVGASGARSLAEDPAVEFVEQDQEVRLNATQINPPWGLDRIDQARLPLSRTYTYPNTAGNSATVYVIDTGVRITHTEISGRARYGYDFVDRDVVASDGNGHGTHVATTVAGRTYGVAKLTRIVSVRVLNNSGVGTLSNVVAGVDWVTSRRVGPAVANMSLGASASRALDTAVRNSIASGVTYAVAAGNSNVNAAYFSPARVGSALTVGASTWLDTRSSFSNYGSVLDMFAPGSWITAGWHTSDTARATLSGTSMAAPHVAGAAAVYLTSHPTAGPGTVRSALVSGATTGALRNVGPGSPNRLLRLVP
>NZ_CP053109.1|WP_171116504.1|6088034_6088250_-|hypothetical-protein
MVLFFSGVAMLLCITQAPKTLTGISAAALPAIAALTCFQQLVRQITLTRAPHKNAPRHRYASPSSKWAVRI
>NZ_CP053109.1|WP_171116483.1|6105787_6106987_+|hypothetical-protein
MAVQHRRRRGWFACGAVGVGVATALALGPGDTSSVGAGKTIARPVPSAMFTGEPSVLPAPPARSATLPAYGAYLDYSPRGVVLMGRLSRWLRGADLRVGHTYLPGDRWSNIEGAPRFLDYWAAWRRESADRILVLNVPMLERNEERASDAEVRHLLRRGAAGEFDVHYRRLAERLVELRVPDTVLVLGWEMNGTTYTHRCGPDPQAWKRYWNRIVTTMRSVAGQRFRFDFAPSRGRDAIPWTECYPGDDTVDIIGMDSYDQPQGMSFDEQVMEPYGLQEHVDFAKAHGKPISYPEWGLFRNSDNAEYMRRMLAWIDRHKPLYNTLTDYCPHGVWQCRENPRAAVVFRSALLGRTEPGSMPEPTPVPLPPNCSPLDLGDWTEYWLGGKLCLDLSWWSRIR
>NZ_CP053109.1|WP_171116480.1|6106885_6108151_-|GNAT-family-N-acetyltransferase
MSGVVQARHDTLWADLCTDEREFAALGPLWERLYRRCGTATPFQSHTWLHSWWTSYGRPGRLRLVLVRDGGELRGAAPLMRVGPPLPRLVPLGGAISDFGDVLLDDEYADRAAALLAEALSAAARTTLIDFREVRPGSAVERVHEHWRGPRRRVRDSLCLELPAVPMEGLVARLPGGKAQRVKSKLRKLNALGVVRRIAAPDEAGTALRRLLALHRLQWQGRRVTPEHLRERFAEHLVRAGGAMVRAGDAVVTEFLLDGEVVAVDLTLLSPRLAGCYLYGVHPLLREVKADIAVMLLDASARHAATGERGTLSLLRGDEPYKHRWCPEAVVNQRLLMARRRTSPLLSAVACHVAARSRVRELVRGSRNGVTAGPEPPAAVGSAGGTAGSPNARPPAQVKAQLSAQPVLGPVAQVQRRAVRG
>NZ_CP053109.1|WP_171119006.1|6108147_6108765_-|lipopolysaccharide-biosynthesis-protein
MFQRLGALPPWSLLAVGTLAGGLAGGAYGALTPPAYSATAYVVAVPAAKSDPQAALGVAQAYGRVATQLAVLADAQVWAGVPVRTLRQSVRSATSPDAPMVAVTATAARADLAVDMANAVTRAMIHHADRTKHATQIGLKQFSRAVRPTEPSSASPVLTGLVGASAGGLLGGLALLIGPRRTTAGDTRPAVVPAPATAADAHSHS
>NZ_CP053109.1|WP_171116478.1|6108827_6109994_-|glycosyltransferase
MKALHVITGLGVGGAEQQLRLLLRHLPARCDVVTLTNPGAVAEGLKADGVRVVHLGMTGNRDVSVLPRLVHLIRSGGYDLVHTHLYRAGVYGRVAARLAGVRAVVTTEHSLGGTQMEGRALSFGVRALYLAGERLGRVTVAVSAAVADRLLHWGVPESRIRIVPNGIDVARFRFDLAVREHTRRRLGLPQSAYVIGGIGRLACGKRFDVLIGALARLPADCWLLLVGGGPQESQLRHAAQRAGVADRVLFTGERPYVPDGSRGPDLPALTSAMDVLASPSPDEAFGLAVVEGLAAGLPVLYASCPAVEDLPPHLAAGARQVRGGADAFARALTEARVPGETGRSLPPSRPASPAAHHYCITRSAVRLMDVYTAAVSCSSPSPLEVKTR
>NZ_CP053109.1|WP_171116476.1|6110021_6110702_-|polysaccharide-deacetylase-family-protein
MYHSVSNCSNDPYRVTVSPGRLDRQLGWLRRRGLRGVGVRELLTARARGAGQDLVGLTFDDGYADFVAHALPLLRRHGCGATLFVLPGRLGRDNAWDPLGPRKPLLSALGIRHAAAAGIEIGSHGLTHVDLTKADDALLRSEVSDSKTLLSEVIGADVHGFCYPYGRLDRRAVAAVRAAGYAYGCATDPDHLGGRFAIPRVHVGENDTAWRLYLKHRLRRRPVEGV
>NZ_CP053109.1|WP_171116474.1|6110772_6112413_-|murein-biosynthesis-protein-MurJ
MTLIPPRTDAPVPPARAGHPDADDARPLSQGFLARAALVTVAFSLIGAVLGLGRDQVLAQLFGAGSETDAFLVAWTVPEFAATLLIEDGLAFALVPAFSAALARRARSGAGDPVRALVRATLPRLSLAFAVVSVLLVCGAPYLVKALAPGLTDPRFAVDCTRLTATCVLTFGLAGYCSAALRAHRRFVAPAAIYVAYNSAVIAAMFLLGARWGVRAAAVGVAVGGVLMVVTQLPPLVRQLRRTPKTSEAAAAAGEASRRVMGYVLVGTVVLFALCRQSQVLVERFLASTLPSGAISHLNYAQKVAQMPMQLALTLCTVTFPVVAQALAEGDTERARDRVERDLEVVSRVVLLGAAAIVACGPQLVHLLFQRGAFTAHDTAATAAVMRVYALGLLGHTLVGALVRSYFSARRPTWYPVAAMTAGVAVTSLSGAATVGSWGVLGIAAANAAGITLTALLLLHGMEARSVPISTRRLLAGMGRPIRAAAGACGIGWLCTNSISSPSFGLAAGGTAVTVVFLLLARAPGEQGLLCALRTVSQRFPHARVR
>NZ_CP053109.1|WP_171116472.1|6112409_6113729_-|O-antigen-ligase-family-protein
MRHAYALPAKRALTPVLPVVAVIALLARPIALGGEGGTTSADAASGVVVLCCAVRLLYLRRRDLSPTAAVVLGLPVVGITVAAVAAGVPDAAVTGLLRHLQIFVLVPAAVLLLVRDRRDVRLLAWAMVALAMWQGSIGVHQYATGTGASYMGRELRAVGTYGPGDIMAMATVVALGLVCAVGLVLGSAPERQRVWALACALLLVVPLAVSFSRGAWIATALACTAQLVLAGLRRAVRVSAVVAAVTVILVGGFGVGSALFQERLSSIGQVAEAPDQSVADRYALWAAATGMWRERPLTGVGLKGFPEHRDGHASLALSSGSDTEGAGATYRKQPLLSPHSMYLLVLGEQGLIGVLTLAGSWLALLVLGLRNLLRARRAQDPGLDCALVACGLLIWHLINFAYADIGGPATILTAVCLGLSAWWALTRPGPGVPEKAAAR
>NZ_CP053109.1|WP_171116469.1|6113735_6115217_-|exopolysaccharide-biosynthesis-polyprenyl-glycosylphosphotransferase
MTAERTVPPPGGPSDRPPEQTGPPVSVIHPRSAADGLRLPAGRRTARRRATGLPLLTMDAAAALTAAPALPHPLLTAPLLLAVLCLNAQAALYRSLATPTVLDELPAVCARIAVSWCALASLVAALSPAHALSARTLLTGCALQSAASWAGRGAVHWHRRRTLARHPAAALVVGPAATAQRVAAAFLRHPACGLRPVGVLSGCAAGGEGLPVLSTEEEAQRAVVQNNVKAVLMVGSAGEHASFLGKLAETGCVLWEVDAEVPVYDRDAGMAYGKAGHTPCGRLPRERIAGFSCRRLAVGRWPDSPAKRALDVLASGILLLLTGPVLLVCAIVLRGSDGPQVIFRQERVGRDGRPFTMLKFRTHRPADPHEAATRWSVAGERNMRPFCRFLRRTSLDELPQLWNVFRGDMTLVGPRPERPYFVATFSQRYPGYAARHRMRTGLTGLAQIHGLRGDTSIEDRARFDNAYIDDWSLWQDVCILLRTATALVRPTGS
>NZ_CP053109.1|WP_171116466.1|6115213_6116428_-|glycosyltransferase
MAGRSSGSPRGATRPEVSRRVLHATQPVDGGVARVVTELVRAQRAVGLDLTVACPDGELRQALGKLGADVRHWPATRAPGPALASGVLRLARLVEQVRPDVLQAHSAKAGLAARLAVRGRIPTVFQPHAWSFEAVGGLTAAVATAWERWAARWTTHVVCVSKAEHARGEQAGVHARWRVIPNNIDPERFHPAAVGAARPALAPLADLDPAALLVVCVGRLCRQKGQDVLLQAWSSVQRRVPGARLALVGNGPQKRPLRSRAPKGVLFTGAVADTVPWYQAADVVVLPSRWEGMALAPLEAMACGRPTVVTNVAGARESLPPDHGAHCLVPAGQPGPLADALTRMLLDPPLRESLGDQGRRHVLAAHNVRHSADAVTDLYLELLDARRTVTHRAEPTECRESIRS
>NZ_CP053109.1|WP_171116464.1|6117143_6117704_+|tyrosinase-co-factor-protein
MALTTAAPSAPDCVAARPVAKSSAAHPAGVTVRRRVLQGLFASALGLAFAPALVASGSALSASRSAGRAPAPAGDEERFDETYRGCRIIGVRYDRRPGGDGSCTWRVTVDGRPLHLMRRADGTWMSMVDHYQSYATPLAATRAAVDELGSTARLGAPGNRRNRTADSRTASVSKGNEGEHHHGVHP

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Crispr_ID: NZ_CP053109_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053109_10

6176396-6176473

Orphan

Consensus_repeat	Method
TGGTTCAAGTCCTCCTACAGCGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP053109_10

>merge|NZ_CP053109|10|6176396-6176473|CRISPRCasFinder
TGGTTCAAGTCCTCCTACAGCGACGGGACGGGAACCAACTGCCTCGAAGCCGCCTGGATCAAGTCCTCCTACAGCGAC

>NZ_CP053109|10|8|6176396-6176473|CRISPRCasFinder
TGGTTCAAGTCCTCCTACAGCGAC	GGGACGGGAACCAACTGCCTCGAAGCCGCC
TGGATCAAGTCCTCCTACAGCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053109.1\|WP_171118998.1\|6168579_6168963_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171116402.1\|6163835_6164735_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176115
NZ_CP053109.1\|WP_171118995.1\|6175347_6176046_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171116398.1\|6165406_6167989_-\|aminopeptidase-N	unknown	unknown	gnl\|CDD\|274121
NZ_CP053109.1\|WP_171116386.1\|6177903_6178359_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|240040
NZ_CP053109.1\|WP_171116370.1\|6188933_6189575_-\|superoxide-dismutase	unknown	unknown	gnl\|CDD\|223678
NZ_CP053109.1\|WP_171116371.1\|6188152_6188791_+\|DsbA-family-protein	unknown	unknown	gnl\|CDD\|376526
NZ_CP053109.1\|WP_171118996.1\|6169266_6169506_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171116380.1\|6182814_6183261_+\|DUF1772-domain-containing-protein	unknown	unknown	gnl\|CDD\|378020
NZ_CP053109.1\|WP_171116378.1\|6183556_6184090_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171116396.1\|6168101_6168590_+\|DUF1203-domain-containing-protein	unknown	unknown	gnl\|CDD\|377693
NZ_CP053109.1\|WP_171134148.1\|6169558_6173092_-\|chemotaxis-protein	unknown	unknown	gnl\|CDD\|235334
NZ_CP053109.1\|WP_171134083.1\|6164773_6165307_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_CP053109.1\|WP_171116384.1\|6178586_6181889_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173796
NZ_CP053109.1\|WP_171116392.1\|6174740_6175283_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NZ_CP053109.1\|WP_171116376.1\|6184168_6185215_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171116374.1\|6185428_6188005_-\|aminopeptidase-N	unknown	unknown	gnl\|CDD\|274121
NZ_CP053109.1\|WP_171116388.1\|6176614_6177757_-\|beta-lactamase-family-protein	unknown	unknown	gnl\|CDD\|365903
NZ_CP053109.1\|WP_171116382.1\|6182144_6182723_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379115
NZ_CP053109.1\|WP_171116394.1\|6173496_6174513_-\|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|237845

Protein	Function_ID	Function_description	E-value
NZ_CP053109.1\|WP_171116402.1\|6163835_6164735_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176115	cd08423, PBP2_LTTR_like_6, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.47787e-44
NZ_CP053109.1\|WP_171116398.1\|6165406_6167989_-\|aminopeptidase-N	gnl\|CDD\|274121	TIGR02412, Aminopeptidase_N, aminopeptidase N, Streptomyces lividans type. This family is a subset of the members of the zinc metallopeptidase family M1 (pfam01433), with a single member characterized in Streptomyces lividans 66 and designated aminopeptidase N. The spectrum of activity may differ somewhat from the aminopeptidase N clade of E. coli and most other Proteobacteria, well separated phylogenetically within the M1 family. The M1 family also includes leukotriene A-4 hydrolase/aminopeptidase (with a bifunctional active site).	0
NZ_CP053109.1\|WP_171116386.1\|6177903_6178359_-\|NUDIX-hydrolase	gnl\|CDD\|240040	cd04684, Nudix_Hydrolase_25, Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	3.61957e-38
NZ_CP053109.1\|WP_171116370.1\|6188933_6189575_-\|superoxide-dismutase	gnl\|CDD\|223678	COG0605, SodA, Superoxide dismutase [Inorganic ion transport and metabolism].	2.76969e-82
NZ_CP053109.1\|WP_171116371.1\|6188152_6188791_+\|DsbA-family-protein	gnl\|CDD\|376526	pfam01323, DSBA, DSBA-like thioredoxin domain. This family contains a diverse set of proteins with a thioredoxin-like structure pfam00085. This family also includes 2-hydroxychromene-2-carboxylate (HCCA) isomerase enzymes catalyze one step in prokaryotic polyaromatic hydrocarbon (PAH) catabolic pathways. This family also contains members with functions other than HCCA isomerisation, such as Kappa family GSTs, whose similarity to HCCA isomerases was not previously recognized. Some members have been annotated as dioxygenases, dehydrogenases, or putative glycerol-3-phosphate transfer proteins, but are most likely HCCA isomerase enzymes.	5.36998e-08
NZ_CP053109.1\|WP_171116380.1\|6182814_6183261_+\|DUF1772-domain-containing-protein	gnl\|CDD\|378020	pfam08592, DUF1772, Domain of unknown function (DUF1772). This domain is of unknown function.	3.20874e-12
NZ_CP053109.1\|WP_171116374.1\|6185428_6188005_-\|aminopeptidase-N	gnl\|CDD\|274121	TIGR02412, Aminopeptidase_N, aminopeptidase N, Streptomyces lividans type. This family is a subset of the members of the zinc metallopeptidase family M1 (pfam01433), with a single member characterized in Streptomyces lividans 66 and designated aminopeptidase N. The spectrum of activity may differ somewhat from the aminopeptidase N clade of E. coli and most other Proteobacteria, well separated phylogenetically within the M1 family. The M1 family also includes leukotriene A-4 hydrolase/aminopeptidase (with a bifunctional active site).	0
NZ_CP053109.1\|WP_171116396.1\|6168101_6168590_+\|DUF1203-domain-containing-protein	gnl\|CDD\|377693	pfam06718, DUF1203, Protein of unknown function (DUF1203). This family consists of several hypothetical bacterial proteins of around 155 residues in length. Family members are present in Rhizobium, Agrobacterium and Streptomyces species.	1.61685e-47
NZ_CP053109.1\|WP_171134148.1\|6169558_6173092_-\|chemotaxis-protein	gnl\|CDD\|235334	PRK05035, PRK05035, electron transport complex protein RnfC; Provisional.	1.11981e-18
NZ_CP053109.1\|WP_171134083.1\|6164773_6165307_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	9.32749e-11
NZ_CP053109.1\|WP_171116384.1\|6178586_6181889_+\|S8-family-serine-peptidase	gnl\|CDD\|173796	cd04857, Peptidases_S8_Tripeptidyl_Aminopeptidase_II, Peptidase S8 family domain in Tripeptidyl aminopeptidases_II. Tripeptidyl aminopeptidases II are member of the peptidase S8 or Subtilase family. Subtilases, or subtilisin-like serine proteases, have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure (an example of convergent evolution). Tripeptidyl aminopeptidase II removes tripeptides from the free N terminus of oligopeptides as well as having endoproteolytic activity. Some tripeptidyl aminopeptidases have been shown to cleave tripeptides and small peptides, e.g. angiotensin II and glucagon, while others are believed to be involved in MHC I processing.	1.00243e-63
NZ_CP053109.1\|WP_171116392.1\|6174740_6175283_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	1.45131e-25
NZ_CP053109.1\|WP_171116388.1\|6176614_6177757_-\|beta-lactamase-family-protein	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.39047e-54
NZ_CP053109.1\|WP_171116382.1\|6182144_6182723_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379115	pfam13305, WHG, WHG domain. This presumed domain is around 80 amino acids in length. It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. The domain is named WHG after three conserved residues near the C-terminus of the domain.	6.54596e-11
NZ_CP053109.1\|WP_171116394.1\|6173496_6174513_-\|aspartate-semialdehyde-dehydrogenase	gnl\|CDD\|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	0

>NZ_CP053109.1|WP_171118995.1|6175347_6176046_+|hypothetical-protein
MAVLTDQPLPDAARADAAFMAEHRSAAADVALLREQLGILGEALTEVPEVPEVSEEPAKSPSPPVRVRPHRRRPFALALGAVGVAAAGAMVVGLGWLLGQAGGGVTETSGAAADSAESDSSSAAGPLGSAEYLACARLVAEGEVTSARPVPGTGEERVTLEVTHSYKPARTDTEVRFVIPTSAGLDEGEQVLVVIRRDSASPDFWLVGEAAIAGQRPLLIRTLPQAGATPCE
>NZ_CP053109.1|WP_171116392.1|6174740_6175283_+|sigma-70-family-RNA-polymerase-sigma-factor
MLRGKARRGQGGDVHGDVGDPLDAAQERRVRAVLALGGVPQADLPDGVQQVRLRLLERAADGREAPRDVSAWAAVVASNLAMDWHRAKRRQERLGERLASLRQPEHAPSGEDTSLLSLAVAQGLDELPDAQRQVLVLRFYADLPVRSIAEELGIPEGTVKSRLHTAVRALRARLHEDEVV
>NZ_CP053109.1|WP_171116394.1|6173496_6174513_-|aspartate-semialdehyde-dehydrogenase
MRVGIVGATGQVGTVMRRILTERDFPVTELRLFASARSAGTVLDGVTVEDAATADYTGLDIVLFSAGGATSKALAEKVAGQGAVVIDNSSAWRRDPEVPLVVSEVNPHAIASRPKGIIANPNCTTMAAMPVLQPLHAEAGLEALVVATYQAVSGSGLAGVDELFEQVKKVGEDAPKLTHDGSAAEFPAPNKYVAPIAYNVLPLAGSIVDDGLNETDEEQKLRNESRKILEIPELKVSGTCVRVPVFSGHSLQVNARFARPISVERAKELLAGAPGVALTDVPTPLQAAGQDPSYVGRIRRDETVENGLALFISNDNLRKGAALNAVQIAELVAAELSA
>NZ_CP053109.1|WP_171134148.1|6169558_6173092_-|chemotaxis-protein
MVVDLYKSGGPGVKAAAEAALTGSDADVENLLSTARELGIQDNRVAAAQLAGIGGSELLDAARTALSGTPEDLETFLSSGWETPLHQDQRVLVAQIISVGGPNVQEAGQAALSGTPEDVQAFLATTQYEAREQDNRVLVAQIISTGGTNVQAAGRLALRGTPEDIQEFLDVGQYIARSRDQERATVAQLAAQAKEAGRQAAKETSAAKEASAKAVKASALAKEAAEKAAEEASLAQQDSVDAAAAAGRAAKAAKEAATAAQQAIAAANAANNSARIAANAAAQAAAAAAGAAQASSRARSAAADAARDAANADAARQAAQQARNAAKGADAAADAADEASKAAAAAGSAALSAISAGANADLAAAAAVEASNFADQSSAQAAEARRAAAAAKRHAAEANRAATAAEALARRAATAAAEARDEARSAAAHANASAAAAEEAADHAGDAATAADKATAHANAATTAANTASKAVTKAQAVFQLAREVEAEELKGRTNAGIEQARDVKEAYDLQQAERASAVQDAKDRDAEAQRLAAAAAQPDADPAQIATDGRKLALLAMQYGDAWSRAAAEVALASPDEYVVDYIRNGWQEARAQDERFRVERLAEDSIVKAVRDAAEVALAGDDATVHAFLTQGQYEVGAQDFRVEIARIADAGGPVQTDEARAALAAGTPAAYREFLATTQYTARTQDERVMAAQLVSAGGPEVQAAARIALEGSPTALHAFIVRGRYMAERKDLLATTHIAQVQQLIAEAAGVAAKAHQDAAEAQESAALARKAAAEAAEYARQADAAAADAQVYADEADRHARDAEASAAQAAESAKTARAAANSANVAANDAALSAATATVSSEMAQTSASIAWSAANEARAMAQAAKQDSAAALAAAKDAYSIAVEKVRAEQEALRKAAVAAKEKAANDAGARAREIYRCNFVGCDEYYNNHPRWCQHNEVLCELEVFGREFASAMEQLHNVTKELTGLGELESCADNLDVQSCWMLLADVTVKSKIKWVELGYDTLRKLFKVNRVCKGATVVDATTSSAQGMSTQLVTAASSSRRWACGEFIKKYDGNGMIMADAQDGVLEIAVERNDSTTRGYQMFDDVMSHFGAENIQKIEGKWVPAMPTNLNKFNQLIREGMTVEEAAAQTFTGRNAARYGFTKISKVTLEGEPGNYKNVRIDFERPS
>NZ_CP053109.1|WP_171118996.1|6169266_6169506_-|hypothetical-protein
MAAEGAGLLAMIEALRSDETFTLTPLHLLRVLNEAFGIPLRESRTLLEFFDPDLRPLVPDAEADRRAAAVLAPYVSRGR
>NZ_CP053109.1|WP_171118998.1|6168579_6168963_-|hypothetical-protein
MEDFNYPGAQKVLETKGILLKRGDGHIVLADCDYNRDQIRVMTVKDASVNRDELYCFEASGTSGWLTLELERVFALETESHPISADLVGTTSGTTVKVDVAKNGFKSVGEGTVDGERSVLVELRVTG
>NZ_CP053109.1|WP_171116396.1|6168101_6168590_+|DUF1203-domain-containing-protein
MTTYIARPIEPPVLKELRSADDAGREMVPVTDEEGGAPLRCCLRRSEPGERIALVSYAPLRRWAAQTGADPGAYDEQGPVFIHAEECPGPQGSALPFTNAHRTLRRYSAEGRIVGGRLVDNGFEAALANAFDDPEVALVHVRAVEYGCFLYEVRRVFGRISR
>NZ_CP053109.1|WP_171116398.1|6165406_6167989_-|aminopeptidase-N
MPGTNLTREEAQQRAKLLTVDSYEIDLDLSGAQEGDTFRSVTTVRFDVAENGVESFIDLVAPAVHEITLNGDPLDPGAVFKDSRIALPGLLQGRNVLRVVADCAYTNTGEGLHKFVDPVDDQAYLYTQFEVPDARRVFTSFEQPDLKATFQFTVRAPEGWTVISNSPTPEPKDSVWVFEPTPRISTYITALIVGPYHSVHSVYEKDGQSVPLGIYCRPSLAEYLDSDAIFEVTRQGFEWFQEKFDYAYPFQKYDQLFVPEFNAGAMENAGAVTIRDQYVFRSKVTDAAYETRAETILHELAHMWFGDLVTMEWWNDLWLNESFATYTSIACQAAAPASRWPHAWTTFANSMKTWAYRQDQLPSTHPIMAEIRDLDDVLVNFDGITYAKGASVLKQLVAYVGQDEFFRGVQAYFKRHAYRNTRLTDLLTALEETSGRDLKTWSRKWLETAGINILRPEIETDPNGVITSFAIRQEAPALPTGAKGEPTLRPHRIAVGLYEMDYDAGKLVREERVELDVDGELTAVPQLVGRPRPSVVLLNDDDLSYAKVRLDEQSLAFVTDHLGDFESSLPRALCWASAWDMTRDAELATRDYLSLVLSGIGKESDIGVVQSLQRQVKLAIELYADPAAREALLTRWTDATLAHLRAAEPGGDHQLAWARAFAATARTPEQLDLLQALLDGSQTITGLVVDTELRWAFVERLAAVGRFEEAEIAGEYERDKTAAGERHAATARAARPTPEAKAEAWASVVESDKLPNAVQEAVISGFVQTDQRELLAPYTDKYFESVKGVWDSRSHEMAQQIAVGLYPSVQVTAHTLAKTDEWLSTAEPSAALRRLVSESGAGIERALRAQGADAAAGAQG
>NZ_CP053109.1|WP_171134083.1|6164773_6165307_-|GNAT-family-N-acetyltransferase
MGDWEIRPASGADVEAVAELRAVVLRGDLERLGRYDERRVRQRLRDGFVPEHTWVIEVGGTFAGCVSLRPTEDAHWLEHFYLAPHLQGAGIGGAVLRTLLQRCDRDGVLLRLNVLQGSPARRLYERHGFAVESEDPVDVFMVRAPGGGGWGSGVCVGAGSRTAGVARVGAAVSRRCG
>NZ_CP053109.1|WP_171116402.1|6163835_6164735_+|LysR-family-transcriptional-regulator
MVEWDIRKLQILRTLRERGTVTATAEALRMTPSAVSQQLTNLSRQLGVPLLEAQGRRVRLTDAARLVLRHAEAVFEQLERADAELAAYVQGEAGEVRVGAFSTAVPALVVPAVRALRAVHPGVSVRVREVEAGEAYELLAAGEVDVALSLAAQAPTVADGRFGVVRLLSDPLDLALPRGHALAGAEGVRLADLAAEPWIFGGSGPWSDITRAACEAAGFQPVQGHSAAGWTAILAMVEAGMGVALVPRMVQVRTDGVVMRELAMERPRRHVVAAVRKGAELGAAGKVLGALREVAAGLG
>NZ_CP053109.1|WP_171116388.1|6176614_6177757_-|beta-lactamase-family-protein
MRSVRVTVVAATAVALSVALAGPALAAPTGGGHDATREALRAAVKDGVPGVTATAKDAHGAWRATEGVGNLRTGEPRSTADRYRVGSITKTFVATVLLQLEAEGTLSLDDTVDEWLPGAVRGNGHDGRKITLRQLLNHTSGIYDYTSDEEFGRTYFLKDGFFEHRYDTKKPAELVAIAMAHKPDFAPGTSWSYSNTNYVLAGMVIEKATGRPYGAEIRDRILRPLHLNATSVPGTRVTVPRPSSRAYSKLAETATGPTYDVTRLNPSLAYAAGEMISDSADLNRFYRALLGGKLLPPEQLKAMKTTVAIDGAPNVGYGLGLLDRELSCGVHVWGHGGGIHGSLSEAVTTPDARHSLAFNFNGDWAGDSEAVIEAEFCGDR
>NZ_CP053109.1|WP_171116386.1|6177903_6178359_-|NUDIX-hydrolase
MRKTLRVAAYAICVRDGQVLLARSPAPDGTPEWVLPGGGMEHGEDPYDTVRREVREETGYRIEVTGILGVHSLHRTFPGRRFRPATDHHGVRLVYEGTVVGGELRHEIGGSTDMAAWHDLDAVSGLRRIGLVDLGLRLWRERPAAGRVDLT
>NZ_CP053109.1|WP_171116384.1|6178586_6181889_+|S8-family-serine-peptidase
MTLTPQSDAIPGTRRVARIAVAAGLVAALAAAGPIPVALAADQAPSAADPSVKSAHDKLGSDDAELLAEAKADGDKSVTMMVATAPGKTEQVAEQLDSVDGGLVGRTYDKLGYVRATVPTGKADAAIAAATKLSSVHGIDLKQEIPLEDPRPNAGSTKGTGATASYPAPGKNTPAKNPYNPSYETGAVDFVEDHPKADGRGITIGILDSGVDLGHPALQKTTTGERKIVDWVTATDPVVDGDGTWRRMTTSVSGPTFSITTPTLGTETFKAPEGSYKFSYFAESATTGGDMAGDLNRDGDTTDVWGVLYDAASGTARVDLDDDLDFTDDTAMKPYKDGFQIGYFGTDNPATEIVERIPFVVEIRKDVVYNAAGAKADYVNIGVIEGSHGTHVAGITAANSLFGGKMNGAAPGAKLVSSRACTWSGGCTNVALTEGMIDLVVNRGVDIVNMSIGGLPALNDGNNARAELYTRLIDEYGVQLVISAGNSGPGANTIGDPSLADKVISVGATISKQTWAANYGSKVEKRYAMLPFSSRGPREDGGFTPTLSAPGAAINTTQTWSPGGPVAEAGYSLPPGYSMLQGTSMASPQATGAAALLLSAAKQKGIELTPATLRTALTSTADHIKGVQAYEEGAGLVDIEDAWDAIRDGASAHTYAVKAPVDTAIDQFLKTPGYGTGLYDREGGLKAGQKKTYEITITRTSGADRAIWHKLDFENNAGRTFRIVGSDWVRLPLNEPVTVKVQAAPRSAGLKSAILEVDDPRTEGIDKQILNTVVVSQPLKYTYSASGSVQRNSTKSYFVTVPEGAKSLEVALGGLKGKSQTRFIAIHPYGVPFDPTSTINCYPNYDNPANTCRPDVRSYADPQPGVWEIEVESRRTSPLLDNPYKLDVTVLGAAFDPETVTVPEAKVGTPAAASWKVTNGYAAIDGKLVGGPLGSSKTTRPTIQQGETQTSTVEVPEGAASLDVVIGNVSDAAADLDLTVYDASGKQVGQSADGDSEEQVTVASPKAGTYTIEVYGYGVPAGSTAYDYRDVFFSAALGSVSVDGSAAVKLGTGDSATVSASVTAAAAAPEGREFFGQVRLVNARGTDAGIGSVKIEKVVP
>NZ_CP053109.1|WP_171116382.1|6182144_6182723_-|TetR/AcrR-family-transcriptional-regulator
MSVQERKQRERADRERLIVATARELAEQQGWDAVTTRRLAERIEYSQPVLYSHFRGKREIIGAVALEGAAEMAAAVRAAASAADDPRTRVAALARTYLDFAARNPAVYDAMFQLDGGLAFANEDTPLPLKDAFAALLETLGEVAGDGVHPALFTELFWAALHGLATLTRAGRLPPGDAERRVELLVDRLAMV
>NZ_CP053109.1|WP_171116380.1|6182814_6183261_+|DUF1772-domain-containing-protein
MLNALEVFTTVVVGVMVGVEFSVAFVINPILNALPEDSGQLGRAHGGRMLGAVMPVWYITSLVLVVVWAIAGWHHHGTGLVVTAGALLILSVIMSLLLLVPINNRGKTWTPENRPEDWKEQMNRWDRFHYVRVAVIIAAFALLVAALI
>NZ_CP053109.1|WP_171116378.1|6183556_6184090_+|hypothetical-protein
MSSPCDPEHAPVGDVGAALMMVDSRLKAIYDDKTQTDTEQQALTEQAVASLGPGGVDDLLDGVCTLIYMFMQWLRRAHEDHDRDVIEYVVPSLVASMRMMRKSVRPEAIPTMAGLVIAAGTGLSPSLWRMQYGDWTDDEMNALEATALLLAEHINRITDDRDFAARLIANALSGVDQ
>NZ_CP053109.1|WP_171116376.1|6184168_6185215_-|hypothetical-protein
MNHDTPLSPRPLHHLSDGRRRVMTAAQLRAHGVSAAETNDHCKPGGPWQQLLPGVYLLHPGPPTSEERLHAVLMYAARQPSPAVPAQPGAEEQRPPYPEAMITGLAALNLHGFAAVPPLPSLDRIDVLVPRLRRLRSTGCVRVLRTTALPTPQVRTGLPVAPVPRALADAVADLADAGAVRRLLTEAVRGGHCEPAAVVRALNQARLLSRPHVVDAVDSLLAEGRAIAEDRLYTMVREYGLPDPVWNVDLRLPGGPHLGGLDAYWPEHAVALELDTRAPRPGHQQEDDALWSEYARKREHLERLGITVVHITPKKLRDAMEQQATVVRTALMASAERDPAAYVVVLPR
>NZ_CP053109.1|WP_171116374.1|6185428_6188005_-|aminopeptidase-N
MPGENLSRDEARERAALLAVDGYDVFLDVRSAVGDGNGEPRTFRSVTTIRFRCAEPGAASFADLIAPSVTALSLNGRDLDPSEVFDGSRILLEDLAADNELTVDAQCAYSRTGEGLHRFVDPEDGEVYLYTQYEPADARRVFAGFEQPDLKAPFRFEVRAPEGWTVWSNGVGERTDGVWRFAETKPISTYITCVVAGPYHYVTDSYTRTFDDGTKLEIPLGAMCRKGLAPYFDADDVFLVTKQGLDFFHDHFDYPYPFGKYDQAFVPEYNLGAMENPGLVTFREEFIFRGKVTQASYENRANVVLHEMAHMWFGDLVTMEWWDDLWLKESFADFMGAFSLVGATRFKDGWITFANRRKAWAYRADQLPSTHPITADIRDLQDAKLNFDGITYAKGASVLKQLVAYVGQDAFLEGARRYFKRHAYGNTRLADLLSVLEETSGRDMAAWARSWLQQAGVNSLTPQVLLDAQGRIDELAVVQEAAESHPELRPHRVAIGLYRRTDAGALQRYARAEVDVHGARTVVAELAGADAPELVLVNDDDLTYCKIRLDETSLDTLRQHLGALTDPLARALCWSALWNMTRDALLPARDFVDLVLRFAGRESEIGVLQMLHAWAESALQHYAAPDWRETGGRLLAEGARRELYDAEPGSEHQLAWARFYARVAEDPVGLKLLRDLLDGAAAIAGLDVDQELRWAFLEPLAAHGVADEKVLAAELARDDTASGKRHQVRCLAARPSQAVKAQAWAQVVESDALSNALVEATIAGFAQASQRELLAPYAEKYFAAIERVWTERSIQIGMDVVRGLFPALQDSPETLAATDAWLAAHEGAAPALRRLVLEARDDLARALRGQACDAAADS
>NZ_CP053109.1|WP_171116371.1|6188152_6188791_+|DsbA-family-protein
MSDKTPVDFWFDPLCPWAWMTSRWVLEVEKVRDVEVRWHLMSLAVLNEDKLDELPEEYREMLATKAWGPVRVVIAAQQEHGAEVLGDLYTALGTRIHNEGQGAEKETVAAALKDVGLPESLMDHWDSTPYEPELRASHKEGIDKVGQEVGTPVISVPGPDGQEVAFFGPVVTPAPKGEEAARLWDGTLAVASVPGFYEIKRTRTKGPDFSNL
>NZ_CP053109.1|WP_171116370.1|6188933_6189575_-|superoxide-dismutase
MPVYTLPDLPYDYSALAPVISPEIIELHHDKHHAAYVKGANDTLEQLAEARDKEQWGSINGLEKNLAFHLSGHILHSIYWHNMTGDGGGEPLEKDGVGELAGAIAESFGSFANFKAQLSKAAATTQGSGWGVLAYEPLSGRLIVEQVYDHQGNVGQGATPILVFDAWEHAFYLQYRNQKVDFIEAMWQVVNWQDVARRYEAAKSRTDVLLLAP

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Crispr_ID: NZ_CP053109_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053109_11

6588245-6588550

Orphan

Consensus_repeat	Method
GACGCGGACGGAACCGTCGCCGGT	CRISPRCasFinder

5 spacers

The CRISPR arrays of NZ_CP053109_11

>merge|NZ_CP053109|11|6588245-6588550|CRISPRCasFinder
CACCTTGACCGCGCCGTCGCCGGTGTCGGTGGACACGCGGTAGGTGGCCCGGGGCACCGAGACGGTGACGGAGCCGTCGCCGCTGCGGGAGTCCACCAGGTCGGGTACGGCGCCGAGTTCGAGGTGGGTGGAGCCGTCGGCGGTGTGGGTGCGGACCTGGCGGGAAGTGACGTCGGCGCGGATGGAACCGTCCTGGGTGCGCAGGTCAAGCGGTCCGGTGGCGGCATCGACGCGGACGGAACCGTCGCCGGTGTGGACGTTCACGGCGCCGGTGGTGTTGTTGACGCGGACGGATCCGTCGCCGGT

>NZ_CP053109|11|9|6588245-6588550|CRISPRCasFinder
CACCTTGACCGCGCCGTCGCCGGT	GTCGGTGGACACGCGGTAGGTGGCCCGGGGCACCGA
GACGGTGACGGAGCCGTCGCCGCT	GCGGGAGTCCACCAGGTCGGGTACGGCGCCGAGTTC
GAGGTGGGTGGAGCCGTCGGCGGT	GTGGGTGCGGACCTGGCGGGAAGTGACGTC
GGCGCGGATGGAACCGTCCTGGGT	GCGCAGGTCAAGCGGTCCGGTGGCGGCATC
GACGCGGACGGAACCGTCGCCGGT	GTGGACGTTCACGGCGCCGGTGGTGTTGTT
GACGCGGACGGATCCGTCGCCGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053109.1\|WP_171112145.1\|6579133_6580021_-\|TerD-family-protein	unknown	unknown	gnl\|CDD\|376767
NZ_CP053109.1\|WP_171112143.1\|6581455_6584146_+\|phosphoribosyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|378594
NZ_CP053109.1\|WP_171112133.1\|6595066_6595534_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NZ_CP053109.1\|WP_171112147.1\|6577080_6578217_+\|DUF475-domain-containing-protein	unknown	unknown	gnl\|CDD\|237583
NZ_CP053109.1\|WP_171112142.1\|6584145_6584958_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319822
NZ_CP053109.1\|WP_171112146.1\|6578339_6579077_+\|Tellurium-resistance	unknown	unknown	gnl\|CDD\|226595
NZ_CP053109.1\|WP_141312282.1\|6576345_6576921_+\|TerD-family-protein	unknown	unknown	gnl\|CDD\|376767
NZ_CP053109.1\|WP_171112137.1\|6589881_6590622_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171112134.1\|6594312_6594942_-\|VTT-domain-containing-protein	unknown	unknown	gnl\|CDD\|223659
NZ_CP053109.1\|WP_171112136.1\|6592438_6593341_-\|2-dehydropantoate-2-reductase	unknown	unknown	gnl\|CDD\|235821
NZ_CP053109.1\|WP_171112132.1\|6595613_6597515_-\|FAD/NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|379196
NZ_CP053109.1\|WP_171112131.1\|6597810_6599451_-\|alkaline-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|277335
NZ_CP053109.1\|WP_171112140.1\|6586694_6588086_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
NZ_CP053109.1\|WP_171112141.1\|6585927_6586512_-\|DUF4383-domain-containing-protein	unknown	unknown	gnl\|CDD\|379556
NZ_CP053109.1\|WP_171112129.1\|6600654_6601236_+\|TMEM165/GDT1-family-protein	unknown	unknown	gnl\|CDD\|225030
NZ_CP053109.1\|WP_171112130.1\|6599603_6600248_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|377857
NZ_CP053109.1\|WP_171112138.1\|6589391_6589742_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_141312291.1\|6585696_6585918_-\|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl\|CDD\|274226
NZ_CP053109.1\|WP_171112144.1\|6580230_6581400_+\|HpcH/HpaI-aldolase/citrate-lyase-family-protein	unknown	unknown	gnl\|CDD\|379744
NZ_CP053109.1\|WP_171112135.1\|6593497_6593731_+\|DUF2277-domain-containing-protein	unknown	unknown	gnl\|CDD\|378364

Protein	Function_ID	Function_description	E-value
NZ_CP053109.1\|WP_171112145.1\|6579133_6580021_-\|TerD-family-protein	gnl\|CDD\|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	4.84213e-65
NZ_CP053109.1\|WP_171112143.1\|6581455_6584146_+\|phosphoribosyltransferase-domain-containing-protein	gnl\|CDD\|378594	pfam11202, PRTase_1, Phosphoribosyl transferase (PRTase). This PRTase family is fused to a C-terminal RNA binding Pelota domain, pfam01248. These genes are found in the biosynthetic operon associated with the Ter stress response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response.	3.46357e-143
NZ_CP053109.1\|WP_171112133.1\|6595066_6595534_-\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	1.18995e-13
NZ_CP053109.1\|WP_171112147.1\|6577080_6578217_+\|DUF475-domain-containing-protein	gnl\|CDD\|237583	PRK14013, PRK14013, hypothetical protein; Provisional.	0
NZ_CP053109.1\|WP_171112142.1\|6584145_6584958_+\|HAD-family-hydrolase	gnl\|CDD\|319822	cd07520, HAD_like, uncharacterized family of the haloacid dehalogenase-like (HAD) hydrolase superfamily. The haloacid dehalogenase-like (HAD) hydrolases are a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members include 2-L-haloalkanoic acid dehalogenase (C-Cl bond hydrolysis), azetidine hydrolase (C-N bond hydrolysis); phosphonoacetaldehyde hydrolase (C-P bond hydrolysis), phosphoserine phosphatase and phosphomannomutase (CO-P bond hydrolysis), P-type ATPases (PO-P bond hydrolysis) and many others. Members are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.7665e-07
NZ_CP053109.1\|WP_171112146.1\|6578339_6579077_+\|Tellurium-resistance	gnl\|CDD\|226595	COG4110, COG4110, Uncharacterized protein involved in stress response [General function prediction only].	4.03664e-50
NZ_CP053109.1\|WP_141312282.1\|6576345_6576921_+\|TerD-family-protein	gnl\|CDD\|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	1.64083e-119
NZ_CP053109.1\|WP_171112134.1\|6594312_6594942_-\|VTT-domain-containing-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	2.60046e-13
NZ_CP053109.1\|WP_171112136.1\|6592438_6593341_-\|2-dehydropantoate-2-reductase	gnl\|CDD\|235821	PRK06522, PRK06522, 2-dehydropantoate 2-reductase; Reviewed.	7.47534e-48
NZ_CP053109.1\|WP_171112132.1\|6595613_6597515_-\|FAD/NAD(P)-binding-protein	gnl\|CDD\|379196	pfam13454, NAD_binding_9, FAD-NAD(P)-binding.	5.45276e-47
NZ_CP053109.1\|WP_171112131.1\|6597810_6599451_-\|alkaline-phosphatase-family-protein	gnl\|CDD\|277335	cd07389, MPP_PhoD, Bacillus subtilis PhoD and related proteins, metallophosphatase domain. PhoD (also known as alkaline phosphatase D/APaseD in Bacillus subtilis) is a secreted phosphodiesterase encoded by phoD of the Pho regulon in Bacillus subtilis. PhoD homologs are found in prokaryotes, eukaryotes, and archaea. PhoD contains a twin arginine (RR) motif and is transported by the Tat (Twin-arginine translocation) translocation pathway machinery (TatAyCy). This family also includes the Fusarium oxysporum Fso1 protein. PhoD belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	5.80061e-32
NZ_CP053109.1\|WP_171112140.1\|6586694_6588086_-\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	1.03474e-06
NZ_CP053109.1\|WP_171112141.1\|6585927_6586512_-\|DUF4383-domain-containing-protein	gnl\|CDD\|379556	pfam14325, DUF4383, Domain of unknown function (DUF4383). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 137 and 164 amino acids in length.	3.06661e-07
NZ_CP053109.1\|WP_171112129.1\|6600654_6601236_+\|TMEM165/GDT1-family-protein	gnl\|CDD\|225030	COG2119, COG2119, Predicted membrane protein [Function unknown].	1.48077e-24
NZ_CP053109.1\|WP_171112130.1\|6599603_6600248_-\|HNH-endonuclease	gnl\|CDD\|377857	pfam07510, DUF1524, Protein of unknown function (DUF1524). This family of uncharacterized proteins contain a conserved HXXP motif. A similar motif is seen in protein families in the His-Me finger endonuclease superfamily which suggests this family of proteins may also act as endonucleases.	1.51202e-11
NZ_CP053109.1\|WP_141312291.1\|6585696_6585918_-\|zinc-ribbon-domain-containing-protein	gnl\|CDD\|274226	TIGR02605, CxxC_CxxC_SSSS, putative regulatory protein, FmdB family. This model represents a region of about 50 amino acids found in a number of small proteins in a wide range of bacteria. The region begins usually with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One member of this family is has been noted as a putative regulatory protein, designated FmdB (SP:Q50229, ). Most members of this family have a C-terminal region containing highly degenerate sequence, such as SSTSESTKSSGSSGSSGSSESKASGSTEKSTSSTTAAAAV in Mycobacterium tuberculosis and VAVGGSAPAPSPAPRAGGGGGGCCGGGCCG in Streptomyces avermitilis. These low complexity regions, which are not included in the model, resemble low-complexity C-terminal regions of some heterocycle-containing bacteriocin precursors. [Regulatory functions, DNA interactions].	1.13392e-10
NZ_CP053109.1\|WP_171112144.1\|6580230_6581400_+\|HpcH/HpaI-aldolase/citrate-lyase-family-protein	gnl\|CDD\|379744	pfam15617, C-C_Bond_Lyase, C-C_Bond_Lyase of the TIM-Barrel fold. This family of TIM-Barrel fold C-C bond lyase is related to citrate-lyase. These genes are found in the biosynthetic operon, with other enzymatic domains, associated with the Ter stress response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response.	1.34034e-173
NZ_CP053109.1\|WP_171112135.1\|6593497_6593731_+\|DUF2277-domain-containing-protein	gnl\|CDD\|378364	pfam10041, DUF2277, Uncharacterized conserved protein (DUF2277). Members of this family of hypothetical bacterial proteins have no known function.	3.16183e-25

>NZ_CP053109.1|WP_171112140.1|6586694_6588086_-|hypothetical-protein
MTATPPQPDSPSMPRAHRSPRVSTAIRDTLTLLSVPLVAALVLPASFAGGGTRRWFGGRAESQRAEAQAAKDAAAAAFYELDTAQRDLRISIETIAAVDASPAARRAAADFEALGRRIDEVSHRYINAVDAHDLDRDDLEASAATRARTELTQAKDELGRVKQDLDRFADGLGPLLGKAETQLARLAPAVERARQSLLAASNALDAVRGSGLKADDLAARLAALAPELTKLNQGAGQHGVPQTLERAERVAREAEAIRAEAERLPERAAEIDRRLVSLRTRAQALTTRAGQVEPVLSELRRRFTVACWQDLQRVPEQAAESVRQAELKLTEAQTARQAQRWPDATALLSTARALLNSTDEAVSAAGDRLKRLNAVQKDPQQEIERTRFAIRDAQRLAMAGRNTPDPRHARPLDDSVGRLERAIATLDGRHPDYWHFLTETEAVRQTVARVVAQIREERGTTAH
>NZ_CP053109.1|WP_171112141.1|6585927_6586512_-|DUF4383-domain-containing-protein
MATHAAHGGERRRIRFDEHLPVDHRLNQVYRFGAGLMGLVLIAFGILGLIGKVGFFDTRGDQVAGLNTNGALSVLSICVGVLLFVGMVIGGNFASTLNMVVGIAFILSGFVNLGLLDTDYNFLAFRIQNVLFSFVFGVVLMFFGMYGRVGSALPHDNPYWRARHPDLVEPEPREQGRGRAVALDESRRPQEDTR
>NZ_CP053109.1|WP_141312291.1|6585696_6585918_-|zinc-ribbon-domain-containing-protein
MPRYEYRCRTCGDTFELSRPMAESSAPATCPTGHDDTVKLLSTVAVGGSASAPAPRAGGGGGGGGCCGGGCCG
>NZ_CP053109.1|WP_171112142.1|6584145_6584958_+|HAD-family-hydrolase
MPVLVASDLDRTLIYSSAALSLTMPDARAPRLLCVEVHESKPLSYMTETAAGLLTDLADAAVFVPTTTRTRKQYQRINLPGPPPRYAICANGGHLLVDGVSDPDWHASVTARLADECASLAEVQEHLLRAADPVWVRKHRVADDLFAYLVVERELLPEDWVKELAVWAENRGWTVSLQGRKIYAVPKPLTKSAAVHEVARRTGADLTLAAGDSLLDADLLLAADKGWRPSHGELADSGWTAPDITSLPERGVLAGERILREFLHASGDRP
>NZ_CP053109.1|WP_171112143.1|6581455_6584146_+|phosphoribosyltransferase-domain-containing-protein
MDKAVNDGVNGANGASGANQVGQSRGIWSGSWVAERLGVELLGDDSLTDLLGLALRRNPKRAHLLVSNVLGKHVPQSPSVVYGSGFALGRRVRELLGATGARSVVVVGYAETATGLGHAVADGLGHAPYLHSTRRPVPGVARAGGFEESHSHATSHLLLPEDPNLLSGDGPLVLVDDEFSTGNTILNTIRALHERHPRDRYVVVALVDMRSTADQNRLTDFATEIGTRIDLVTAARGTVRLPDGVLEKGQALVAAHERGAVGVAEVGQSVAVAGEPDPAGAVVAGADAAGAVVAGADSAGAVVAGAEQQVGPVVAERGWVTRVDLRWPVGVPDGGRHGFTAAHRRRLETALPAMGARLAEALPPGARRVLVLGCEELMYAPLRLARELEHLVSPADIRFSTTTRSPVLAVDDPGYAIRTRLVFPAHDNPADGPGERYAYNVAGGAFDAVVAVVDSTADTPALHAPDGLLAQLAQHTPHILLAVVPSYVPAASPAPERPAMLPEPLRGPAFSSYAPEEVGWLLQDLSDVTLEAPTEEREEAIQSGGAHYAESLPVEYQPSEQYQALFHAALETSAARIAHAVGVVTETVLAELPHSRLRSGGGTPIPRPVLVSLARAGTPVGVLMRRWAQHRHGLDLPHYAVSIVRGRGIDANALRWLADRHDPRDVVFVDGWTGKGAITRELAAGLREFEESEGITGFDPEIAVLADPGSCVRTYGTREDFLIPSACLNSTVSGLISRTVLRADLVGPHDYHGAKFYRELAGADVSTAFLDAISARFDEVTDAVDAATKELLSADRTPTWEGWAAVERISEEYGIHDVNLVKPGVGETTRVLLRRVPWRILARAGAGPDLDHVRLLAEQRGVPVEEVGELPYTCVGLIHPKYTRGATGADGKAVAV
>NZ_CP053109.1|WP_171112144.1|6580230_6581400_+|HpcH/HpaI-aldolase/citrate-lyase-family-protein
MRHFGHIAPEVRQRLFHREPCEFTADSPARLLSAALGATLYSPATRPRLAEDIVKQTDRGVVSMVLCLEDSIGDGDVPAGEENLVRQFSDLAERASGAELPLLFIRVRTPEQIPDLVRRLGPAVRLLSGFVLPKFTEERGIPFLEALALTETASGRRLFAMPVLESPELLYRESRVETLEGIFRAVDKYRDRVLALRLGVTDFCSSYGLRRAPDMTAYDVQIVASVIADVVNMLGRADGTGFTVTGPVWEYFRVQERMFKPQLRRSPFLEGQAEELREALIEHAMDGLLREITLDQANGLLGKTCIHPSHVLPVHALSVVSHEEFSDAQDILRPERLGGGVLRSAYTNKMNEVKPHRAWAERTLLRAEVFGVANEDIGFVELLAAGIPG
>NZ_CP053109.1|WP_171112145.1|6579133_6580021_-|TerD-family-protein
MTHAMLKGSNVPLEATTVRAVLRWTPGQGVPDVDASALLLGPDGRVRSDEDFVFYNQPRHPSGKVWRLGKKRVAEGLTDTIQTDLSGVESDVSQILLVASADGVTFDRVRALRIMLYDAAAPEAEPLAYFEVKPETGQETALICGELYRRGEGWKFRALGEGYSNGLKGLATDFGISVDESEAAAEESADADGTSAAAQAGPEVSRPLPPEQPTAVVPQQTTQPAYGYPQQQQQPAATQPAYGYPHPTSRPAYGYPQASPETAQSGYGYPPPVPVPAAPDPDFRLPPQGPQFIGR
>NZ_CP053109.1|WP_171112146.1|6578339_6579077_+|Tellurium-resistance
MGLFDGLWRGRTTEFDSGSAASNAIELTKRHSQVSLTKQGAATGNLRINLAWRMRSSDIGGPQRESLLRHPFRALKPPEVLGHSQSMVNVDLDLGCLYELQDGTKGVVQPLGGYLGDVNAPPYVKLSGDDRFGSASGETIYVNLDQREAIKRLLVFVYIYDQTPAFDRTHAIVTLYPSNGPRIEIHLDERHPQARSCAVVMIENVKNEVWVRREVKFVYGFQAELDRLYGWGLQWGRGHKVKSQR
>NZ_CP053109.1|WP_171112147.1|6577080_6578217_+|DUF475-domain-containing-protein
MVLKTFGWSFAVTALGLVAAVFYGGWTAFGIVAILCILEISLSFDNAVVNAGILKKMNAFWQRIFLTIGILIAVFGMRLVFPVVIVAVSAQLGPIEAVDLALTDKDRYQELVTDAHPAIAAFGGMFLLMIFLDFIFEEREIKWLGWLERPLAKLGKIDMLSVCIALIVLLITAMTFATHAHLHAGPADKSATVLLSGVAGLITYMIVGGLSGYFEEKLEEEEEREHEQEEEARRTGKPVMLLAGKAAFFMFLYLEVLDASFSFDGVIGAFAITNDIVMMALGLGVGAMYVRSLTVYLVRQGTLDDYVYLEHGAHYAIGALAMILLVTIQYEISEIITGLIGVVLIAWSFWSSVRRNRALAAAEGKAGSDDKTEVASGV
>NZ_CP053109.1|WP_141312282.1|6576345_6576921_+|TerD-family-protein
MGVTLAKGGNVSLSKAAPNLTQVMIGLGWDARSTTGAPFDLDASALVCSSGRVLGDEWFVFYNQLKSPDGSVEHTGDNLTGEGDGDDESLLIDLSKVPAQCDKIVFPVSIHMADERGQTFGQVSNAFIRVVNQADGQELARYDLSEDASTETAMIFGEVYRYQGEWKFRAVGQGYASGLRGIALDFGVNVS
>NZ_CP053109.1|WP_171112138.1|6589391_6589742_-|hypothetical-protein
MATTYDFPSDLRAGQEELHQVRAELSALLKRLPWSVEPLDGFSDAGGWRKIERPASPGWTTDEQAEVEKLRRRERELAIFVSTHRYWSELTGPDHVDARAKLKHADETPPDPERDA
>NZ_CP053109.1|WP_171112137.1|6589881_6590622_+|hypothetical-protein
MPAPPDPAVLYSDVVASGSLAAALQAEAESCLGAVPVTSPGFAPLLHATVASTLRHREPLQISAWSHERRWSIRGTESFQGMPLIDGRTDDLAEVARAARAWRDGAALDDIRRAAPFVHRTGRFEVPDLDPVRLTESEWQGMRQEAGELEYDWQGTYQAMIEAAHAEPTLLALYPFTSHWALRFSTTTRPRLTVVGPCLTANTDGTYGVGRGFISDDLGRFTSVHEAVALAVRQLPSGLGPVTLGV
>NZ_CP053109.1|WP_171112136.1|6592438_6593341_-|2-dehydropantoate-2-reductase
MAHNKLTVAVLGPGGVGGLLAALLARAGHRVICLAGDTTAHTLRTTGIHVRSPRYGDFTTPVEADTELREPVDACLITVKHTTLDAALPRIPAPTLGDALLVPFLNGVEHPAHLRSRYRPHQVAPAVIRVESSRVTPGEIEHTSPFAEIDLTGDLVPRHRLDTLATAFTTAGLTTRVLDDEAAALWAKMSFLAPFALLTTRYSLPLGDIRTHHRDELTALVAESAAVSRACGGPADPAEALARFDAFPPGTKSSMQRDAEAGRTLELDAIGGALLRAAEQHDVPTPVAAKLVRELREAGH
>NZ_CP053109.1|WP_171112135.1|6593497_6593731_+|DUF2277-domain-containing-protein
MCRSIKTLRPPVLPEEATEAEIRAAALQYVRKVSGFREPAAHNREVFDRAVDVIAEATAELLGGLEVRGQGVARKAG
>NZ_CP053109.1|WP_171112134.1|6594312_6594942_-|VTT-domain-containing-protein
MLESVGSLTGSPWIYAMVAASILLDVFVPVLPSGVLVIMAATAAAAGSGAATGQVPTDVPDILLLTLCATTASVLGDLVAYRLAWRGGARLDRALARSPRLSTAQERLGTALARGGGALVVLARFAPAGRSVVSLTAGAARRRPRDFVPWSALAGLTWATYSVALGYFGAHWLGTTWLATAVSTLALVGAGAAATYLMRRPRTSEGDPA
>NZ_CP053109.1|WP_171112133.1|6595066_6595534_-|DoxX-family-protein
MTERLHTAQPYAIGLFRIVTGLLFLCHGAASLFGVLGGAAGTDGGTIPAGTWPGWYAAVIQLIGGGLVMLGLGTRVAACVASGSMAYAYFYVHQPAGLWPMANGGEAAAMFCWALFLLVFTGSGALGLDALFARRAEAKRNPGASTEAQESPVAA
>NZ_CP053109.1|WP_171112132.1|6595613_6597515_-|FAD/NAD(P)-binding-protein
MAIALVGAGPRGTSVLERLCASASELLPPGTPLTVHVIDPAPPGPGRVWRTAQSAELLMNTVASQVTLFTDESVDCSGPIRPGPSLYEWADGALGPDDYPTRAQYGRYLEWVFAQVVRDSPPGVRVETHTARAVRLDDGSDGCQVLTLDDGRVLTGLAAVVLAQGHLPTAPDAEQRQQTSYAARNGLRYIPPANPADVDLAPLSPGEPVLLRGLGLNFFDHMALLTTGRGGRFVRTGDVLRYLPSGREPRLYAGSRRGIPYQARGDNAKGPYGRHEPLVLTPEVIAGFRKRADSGEAPDFLAEVWPLVAKEVETVYYAAVLGGDARLPDGDATPLGGPREFVERYLAVPHGDPLEARLLDEFGVSVADRWSWERISRPFAGRAFDGPGSWRDWLLSYLREDAAQAALGNVRGPLKAALDVLRDLRNEIRLIVDHAGLSGVSRRDHLDRWYTPLNAFLSIGPPRRRIEELTALMEAGVVEVLGPRLEVRCAEGAWVAHSPEVPGSAMRVTTLIEARLPEPDLRRTADELLARLLRTGQCRPHTIDGYETGGLDVTGRPYRLMDRQGQPHEGRFAFGVPTEGVHWVTAAGARPGVDSVTLSDADAVARAVLRVAAGPEAGAGPHQRENVEVASID
>NZ_CP053109.1|WP_171112131.1|6597810_6599451_-|alkaline-phosphatase-family-protein
MAGLRLGPLLRYVGDSTATVWVEASRPCTAEVRCADGAHGTARTFQVAGHHYALVPVTGLTAGTTTSYEVLLDGTRVWPQPGSPFPPSVIRAGFVGDTVKVAFGSCRWAAPPADGKDPVGPDALDTLAARIAAAPTAERPDVLLLLGDQVYADETSRATQRRLAARRDLKEPPGSGVADYEEYTQLYYESWLDSQVRWLLSTVPTCMIFDDHDVIDDWNTSASWLADMRATDWWQERVLSGLMSYWVHQHLGNLSPAELAADPLYAAVRDTPDATDLLRAFAHEADADPTSVRWSYRRDFGRVRLLMVDTRAARVLAEGKRAMLDAGEEAWLRSEALDEPGSYDHLLIGASLPWLLPHLAHDAEGWNAALCRGEKGERWARWGEKMRRAADLEHWSAFPESFDALAALIAEVGSGDRAPATVCVLSGDVHHAYVAEPTWPSGGPHARVLQLTCSPVHNSIPAVLKWGFRFGWSGVARFLGRRIAGHGKVPQPSIDWRCTGGPWFGNQLMTLTMTGRSARLLLEHTRDDGRGGARLTTVEESVLTTA
>NZ_CP053109.1|WP_171112130.1|6599603_6600248_-|HNH-endonuclease
MPRFYARRRLSTVAAISAFVASVALFNAPTASAALPTPVSGATARSYLAQLTVRSEDRTGYSRDLFNHWITISGSCNTRETVLKRDGSNVVTNSSCAATSGSWYSPYDGATWYAASDVDIDHLVPLAEAWDSGADSWSSSRRQAFANDLTRPQLLAVTDNVNQSKGDQDPATWMPSRTAYRCIYVRAWVQVKYYYDLSVDSAEKNALTNYLASC
>NZ_CP053109.1|WP_171112129.1|6600654_6601236_+|TMEM165/GDT1-family-protein
MISLTVTALVFGVVFLAELPDKTALAGLVLGTRYRASYVFAGVAAAFALHVALAVAAGSALTLLPQQLVHALTGVLFLGGAAMLLLKKGDGEEEIRRPQDQSFWKVSGAGFMLILVAEFGDLTQIMTANLAARYDDPLSVGLGAVLALWAVAGLGIVGGRALMKRVPLGLITKIAALLMLGLGVWSLWEAVTG

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Crispr_ID: NZ_CP053109_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053109_13

6623609-6623697

Orphan

Consensus_repeat	Method
GCCGACGCCGCGCAGTCCGCCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP053109_13

>merge|NZ_CP053109|13|6623609-6623697|CRISPRCasFinder
GCCGCGGACGCCCAGTCCTCGGCGACGGCTGCCCGGAAGGCGTCGATCCAGGCGGGAAAGGACGCCGCCGCCGCTGCCCAGGCCGCGTT

>NZ_CP053109|13|11|6623609-6623697|CRISPRCasFinder
GCCGCGGACGCCCAGTCCTCGGC	GACGGCTGCCCGGAAGGCGTCGATCCAGGCGGGAAAGGACGCC
GCCGCCGCTGCCCAGGCCGCGTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053109.1\|WP_171112110.1\|6619230_6619872_-\|IS5/IS1182-family-transposase	unknown	unknown	gnl\|CDD\|372577
NZ_CP053109.1\|WP_171110963.1\|6630392_6631628_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP053109.1\|WP_171110967.1\|6628741_6629020_+\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
NZ_CP053109.1\|WP_171112116.1\|6613484_6614321_-\|nitroreductase	unknown	unknown	gnl\|CDD\|380313
NZ_CP053109.1\|WP_171112112.1\|6618086_6618869_-\|RICIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|379501
NZ_CP053109.1\|WP_171110965.1\|6629003_6630173_-\|steroid-3-ketoacyl-CoA-thiolase	unknown	unknown	gnl\|CDD\|181145
NZ_CP053109.1\|WP_171112111.1\|6618953_6619250_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171110957.1\|6634618_6635545_-\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|378961
NZ_CP053109.1\|WP_171118535.1\|6612468_6613440_-\|patatin-like-phospholipase-family-protein	unknown	unknown	gnl\|CDD\|132848
NZ_CP053109.1\|WP_171112118.1\|6610759_6611248_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171112115.1\|6614460_6615111_+\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224103
NZ_CP053109.1\|WP_171112113.1\|6616019_6618056_+\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|379588
NZ_CP053109.1\|WP_171112117.1\|6611248_6612472_-\|oleandomycin-glycosyltransferase	unknown	unknown	gnl\|CDD\|273616
NZ_CP053109.1\|WP_171110970.1\|6627933_6628782_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262
NZ_CP053109.1\|WP_171110962.1\|6631802_6633857_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP053109.1\|WP_171111843.1\|6626628_6627045_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171111842.1\|6627406_6627787_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP053109.1\|WP_171134089.1\|6624450_6626580_-\|VCBS-repeat-containing-protein	unknown	unknown	gnl\|CDD\|365866
NZ_CP053109.1\|WP_171110960.1\|6633941_6634358_-\|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl\|CDD\|380090
NZ_CP053109.1\|WP_171112114.1\|6615167_6615644_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759

Protein	Function_ID	Function_description	E-value
NZ_CP053109.1\|WP_171112110.1\|6619230_6619872_-\|IS5/IS1182-family-transposase	gnl\|CDD\|372577	pfam13359, DDE_Tnp_4, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	8.80661e-20
NZ_CP053109.1\|WP_171111842.1\|6627406_6627787_-\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	1.99985e-17
NZ_CP053109.1\|WP_171110963.1\|6630392_6631628_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	3.93195e-97
NZ_CP053109.1\|WP_171110967.1\|6628741_6629020_+\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	9.77418e-16
NZ_CP053109.1\|WP_171112116.1\|6613484_6614321_-\|nitroreductase	gnl\|CDD\|380313	cd02136, PnbA_NfnB-like, nitroreductase similar to Mycobacterium smegmatis NfnB. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.	3.73834e-48
NZ_CP053109.1\|WP_171112112.1\|6618086_6618869_-\|RICIN-domain-containing-protein	gnl\|CDD\|379501	pfam14200, RicinB_lectin_2, Ricin-type beta-trefoil lectin domain-like.	2.61622e-20
NZ_CP053109.1\|WP_171110965.1\|6629003_6630173_-\|steroid-3-ketoacyl-CoA-thiolase	gnl\|CDD\|181145	PRK07850, PRK07850, steroid 3-ketoacyl-CoA thiolase.	0
NZ_CP053109.1\|WP_171110957.1\|6634618_6635545_-\|ECF-transporter-S-component	gnl\|CDD\|378961	pfam12822, ECF_trnsprt, ECF transporter, substrate-specific component. Energy-coupling factor (ECF) transporters consist of a substrate-specific component (known as the S component), and an energy-coupling module. The substrate-binding component is a small integral membrane protein which captures specific substrates and forms an active transporter in the presence of the energy-coupling AT module.	9.11379e-15
NZ_CP053109.1\|WP_171118535.1\|6612468_6613440_-\|patatin-like-phospholipase-family-protein	gnl\|CDD\|132848	cd07209, Pat_hypo_Ecoli_Z1214_like, Hypothetical patatin similar to Z1214 protein of Escherichia coli. Patatin-like phospholipase similar to Z1214 protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.	7.106e-43
NZ_CP053109.1\|WP_171112115.1\|6614460_6615111_+\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|224103	COG1182, AcpD, Acyl carrier protein phosphodiesterase [Lipid metabolism].	4.1277e-48
NZ_CP053109.1\|WP_171112113.1\|6616019_6618056_+\|phosphatase-PAP2-family-protein	gnl\|CDD\|379588	pfam14378, PAP2_3, PAP2 superfamily.	1.64951e-42
NZ_CP053109.1\|WP_171112117.1\|6611248_6612472_-\|oleandomycin-glycosyltransferase	gnl\|CDD\|273616	TIGR01426, Glycosyl_transferase, glycosyltransferase, MGT family. This model describes the MGT (macroside glycosyltransferase) subfamily of the UDP-glucuronosyltransferase family. Members include a number of glucosyl transferases for macrolide antibiotic inactivation, but also include transferases of glucose-related sugars for macrolide antibiotic production. [Cellular processes, Toxin production and resistance].	1.19486e-144
NZ_CP053109.1\|WP_171110962.1\|6631802_6633857_+\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.33083e-48
NZ_CP053109.1\|WP_171110970.1\|6627933_6628782_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	8.53963e-09
NZ_CP053109.1\|WP_171134089.1\|6624450_6626580_-\|VCBS-repeat-containing-protein	gnl\|CDD\|365866	pfam00089, Trypsin, Trypsin.	7.70147e-16
NZ_CP053109.1\|WP_171110960.1\|6633941_6634358_-\|transglycosylase-SLT-domain-containing-protein	gnl\|CDD\|380090	pfam18013, Phage_lysozyme2, Phage tail lysozyme. This domain has a lysozyme like fold. It is found in the tail protein of various phages probably giving them the ability to degrade the host cell wall peptidoglycan layer.	5.35459e-05
NZ_CP053109.1\|WP_171112114.1\|6615167_6615644_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	1.78833e-15

>NZ_CP053109.1|WP_171112110.1|6619230_6619872_-|IS5/IS1182-family-transposase
MHCLARDAGISQATCYRYLHEGIGVLAAQAPDLYEALDLCRAEGMTHVVLDGTLIACDRLAGVRENGNDLWSSQKHKSFGGNIQFLAAPDATPLWVSDVEPGSTPDITAAPIHVLPALYKAAADRLPTLADKGYIGAGIGIHVPVRRPKGHSETALDRGTPATNALIRHLRARGERTAAELKERWRALKHVTLSPSRIGDIARAALVLNGQWK
>NZ_CP053109.1|WP_171112111.1|6618953_6619250_+|hypothetical-protein
MTTASVDTNGKRTDAVHDGLGRVIKVWLPGWSKSGHAGQPSAEYTYKVSKTAANAVATKTLRYVRTPPATSSTTARIVLGFSLAGSEVFPVEIISIAR
>NZ_CP053109.1|WP_171112112.1|6618086_6618869_-|RICIN-domain-containing-protein
MNSQLRSRTRTGRPFHTSRVTVPTTAPEILSGVGRSGCPTGCIPARSPSPASAAWSWTSTARTAPRSARGDAGGPVVRAGTAGDELVGVSSRSWQGGCFGSEETRTGAVASRADDLATWVTTAVTAPHTLTNKATGKCLAVPQASTDNGTKLIQWTCTGNSEQQWHLEKVAGGNGDRYRVRNQNSNRCLAIPQAGLDNGTQAIQWTCSGSNDQIWINDSIGRLRNLNSDKCLAIPQANPAIGTGAVQWTCSTNTDQRWTW
>NZ_CP053109.1|WP_171112113.1|6616019_6618056_+|phosphatase-PAP2-family-protein
MANAEHSGRPVGVLGPTVGARLRAARLALWLVATILGVRQIAVVLSTPRGERLTDLETWVGPDGVLHVEGSLYDSTRFTGTPFGGLVLKPLTRSAEQALGWGWTFGTLLLVVVLGLVAARALPPPISRRTSLVAAPVAICLLMLSLPVRNAFWLGQTSIIPVLLVLLGCFAVRGERAGGALIGVAAAFQPTVLLFAPLLWFTGRKKAAASLGVTFASCTALAWAAMPQDSYTYWVHHLAGVGLGGRADDLANQSLHGALLRLGLSGPLEIVLFLVLGAAVATLGLRRAVRYARDGQLLLAVAITGCAAIVVAPTAWQHQLLWVLLAVVGRVGRRASDRLVWPVAVVLVMTLPAKMLLPNMAALHPLRDNVVLLAAIAAATAVPFLSRTSPYYRAPIPTDYAPPVPGRWKHIPLLPFLRRVLGRPNLLLELLLIRVTYAAYSKVRLAATGGTISGGRERAEEHGEQILSLERVLHLDIEHTLNHAIVKVDWLRQFFDFYYTSFHFTIPLTVLAVLYWRRPVDYRWARSTLGLTTLLALIGFWLYPLAPPRLMPDLGIIDTVHGVQDFSQPDYGTLTALTNQYAAMPSLHFGWSLWCGVVIAIVAPKGWMKALGLLHPTLTVTAIVVTGNHWVLDAVGGALVVGAGFGLAYLFQGPRARAVTAVAASPEREPEPTAGKIG
>NZ_CP053109.1|WP_171112114.1|6615167_6615644_-|MarR-family-transcriptional-regulator
MTADVPHRNAASRVTDRPGDTSPFALGLLLRRAHWRAAAVMEEALRPLGIELRHFAVLIVLVERGPTVQRDLVAATGSDKAGIMRVVDDLERKGLAVRKSVPGDRRVRAVEITPAGVELFDAAHVAAEPLAERLVAELGPGEAEQLRELLTRFAHPGS
>NZ_CP053109.1|WP_171112115.1|6614460_6615111_+|NAD(P)H-dependent-oxidoreductase
MATLLHIDSSVLPGEASASRSVAAAFRKAWEEQHPEGTVIHRDLAADPVPHITADAWSAGFTAPSERTPEQAAAFAARVRLIEELEQADAVLIGAPMYNYSIPSTLKAWLDNVILLGRTWGENPSAQGTPVTVVASRGGSYAPGTPREDFEFVQNYLEAVLKRTLGLDVDFIVAELTMAPRNPDMAELIPLYEASRERAFRDATTKAKELAERLAA
>NZ_CP053109.1|WP_171112116.1|6613484_6614321_-|nitroreductase
MDVYEAVRSRRAVRGFTDRHVPREVLERALSAAAWAPSASNLQPWHAYVVTGAPLAELRKRAAERLAAGEPWDEPEYEQYPPALKSPYRERRSAFGEQRYGALGIPREDLEARQRAAAANWDCFGAPAALFCYIDRDMGPAQWSDVGMYLQTVMLLLRAEGLHSCPQMAWAKYHRTVAEVLSPPDEFMLVCGMSIGFEDIRVGCTRTGRAPLGDTVTFVDTVDTADRTRLPTETAAACSPSRAPHGRRRPRVVARLGDGFTRHLGRLASQIGLPPGAG
>NZ_CP053109.1|WP_171118535.1|6612468_6613440_-|patatin-like-phospholipase-family-protein
MIAHERRRTMPSEASPSRDSASAGLHALPRPVAVVVGAGGVLGAAHVGVGYALEERGFVPDMIIGTSVGALNGAIAAAHPDRAAPWLDHVWTRLRRREVYPLGYPSSRAGIFTDRGLRRLIARSGLPSRIEELAVPFTAVAMDLGTGAAALLDHGDLESALLAGAAIPGILPPVDREGRTLVDGGVIAYVPVLAARQAGAASVVVVVTGPESSPLSPTVPRRRAGAIAARARQLMLHHQIERDLHEVSRHIPTVVLPTGVDTWPAPWDFGHTRRLISTASGTAGRFLDGLRVCGPGLYRVEDAPAVPAGPGEPSTSSASGAAL
>NZ_CP053109.1|WP_171112117.1|6611248_6612472_-|oleandomycin-glycosyltransferase
MSTVAFLNIAMHGRVNPTLPVVAELVRRGHSVTYHTSPAFREEIEAVGATVCLYAGGDQPLPDPPTPVTLIEGLAGTAVRLLPAVLADLRRIRPDLIVHDNACPWGAVAARELEVPAASSFTTFAFNRHVPSPTRGSWDLLAAAMARPRRVQGYLRSRWELRRRFDASGLPWVDLGNIRQPLNLVYTSRAFQPAVEEFDQSYRFVGPSIGARPDDPSFPADRLRDPVLYASLGTVFNADPRLLRSFATGLASLGGTVIVSTGQTDPAALGPLPEHVLARRFVPQPEVLARAALFVTHGGMNSVNEAMYAGVPMLVVPQGADQPMVARRIVELGAGLSIRTEDVTEGSVRALAGHLLHEPRFRAAAATLRVAQHEAGGHRRAADELERYLHAAGSVGRPAPVDPSQWG
>NZ_CP053109.1|WP_171112118.1|6610759_6611248_-|hypothetical-protein
MMSLVVFLLLLAGVSEAAGRIVPLAVRRPGMSRPLVAGLLVAGGLVEAAVFTLWPLTAWTLAELVLPSEPPGAGLAWTPDLVAPLVLAAVLAFPLLGPLLHLLLFVGVGAGLAGPLAAATGLGWWGAAGCVAVAGAGLGVAVEAVRRLVVRISATEGRESTA
>NZ_CP053109.1|WP_171134089.1|6624450_6626580_-|VCBS-repeat-containing-protein
MSLPQRHLRRAALLAVGAVLLAPVPVAQAVVGTPAPDDGTFAFTAHLSIGNGARSCSAALVDPEWLVSAASCFAADPQSGTAPAAGKPALKTVATIGRVDLTATDGGHVTEVTHIVPRAGRDLAFARLATPATGITPVKLATTPPAAGDELTALGFGRTKTEWVPDRLHQADFNLDSVADGTLAMTGKTADDSVCKGDTGGPVLRTTGSGSYELVAVNSRSWQGGCHGTTETRTGAVAARADGSPGGATLTAGQTLRPGDSLLSKSAKVTMGTDGNLTVASNAGKTLWSSGTAGHPGATATFSETGNLAVKAADGTTLWESKTSAPGGSAILGDVGDLVVYNAQNQSQWSSNSAPRHDYNGDGRSDMAAWYNFTAGTDNIYTFLAATDGGISTPKRGFTFPVGAWEAKNHKLVTGDFNGDGRGDIAALLGYSDTTVKLWTFLGKPDGTFAEPVEAWSSPAGGPFHKTYMTPQSGDFNGDGRDDIAVWYAYPDGTTKIWTYLSTASGTFNAPTSSWSAPTGTWARTRAKIITGDFNGDGRDDLSVFYGQGDDSIKTYVFNAQPNGGFAAPTVWWRTLALDWNRAYPHSGDFNGDGRDDATIWYDYPDGSDKTSTILSENVDGTDRFGSAKVTLNSPGGLDITRSQLVVGDYNGDGRDDLSIMHHLADDGVKMWTWTARPDTLFNSGLAGYTVPATSWDYTLSRFANTYNY
>NZ_CP053109.1|WP_171111843.1|6626628_6627045_-|hypothetical-protein
MFNGASIATADDVPPVAVEDFAYPDADQIYADTGIRLISGDGHILLADCGPTGLIEVFARNMDMSKFCFSVKGTSGRIAMEVPQVFGIKGNDYQIVADMTVDGTETSYEITRNQWTPVGETADPEARDHTLVELRATQ
>NZ_CP053109.1|WP_171111842.1|6627406_6627787_-|ATP-binding-protein
MSLTVGEHSARHIRRIVRSLLTEWEMPDLADAVELGVTELVANVVRHVPDRRCTLLLVRQKTGARVEVSDGSPQLPCPSTTLSPDAENGRGLVLLDAVADKWGVEPRSGGGKTVWFECESADAPLL
>NZ_CP053109.1|WP_171110970.1|6627933_6628782_+|helix-turn-helix-domain-containing-protein
MTHINVLDPGASPLDYYGYELRRHREAAGLTQRQLGEIVNYTGSLIGQIETARKLPTPAFSERVDAALGTGGLLSRLTELVLRSQLPAWFQQVAELEARAVEICAFQTHMVHGLLQTAAYARGVLGALDQSNLDDRTAVRLARQRIFKKEEPPVFWAILSEAALYQQIGNPETMREQLAHLLSFEGDPRINMQVLPFSVGAHAGLTGSFNLYRFPSDPTIVYTEGYGSGHPTANPDTVKNCSLRYDHLQAAALSLRDSAELIRRVMEERYGEQRDSDGGPVA
>NZ_CP053109.1|WP_171110967.1|6628741_6629020_+|DUF397-domain-containing-protein
MASNAIPTVAQWRKSSYSSDQGGQCVECAPVGLAWRKSTYSSDQGGDCIEIAESPCATIAIRDSKTPTGPMLTVAPAAFTTFVSWSAATAAE
>NZ_CP053109.1|WP_171110965.1|6629003_6630173_-|steroid-3-ketoacyl-CoA-thiolase
MAAEPVIVEAVRTPIGKRGGALANLHPAYLLGETYRELLGRTGIPADCVEQVVGGTVTHAGEQSMNPARTAWLTMGLPYETAATTVDCQCGSSQQASHMTANLIAAGVIDVGISCGVESMSRVPLGSGSKHGPGKPFPDEWNVDLPNQFEAAERIARHRGLTRENVDTLGLLSQQRAANAWSEERFKRETFAVQVPTTEEEQHAGQGMWRLVDRDEGLRDTSMEALSGLKPIMPTAVHTAGNSSQISDGAAAIMWASKRMARALKLKPRARIVAQALVGADPHFHLDGPIDATRAVLGKAGMTLKDIDIVEINEAFASVVLSWAQVFEQDLEKVNVNGGAIALGHPVGATGARLITTALHELERADKEFALVTMCAGGGLATGTIIQRL
>NZ_CP053109.1|WP_171110963.1|6630392_6631628_+|cytochrome-P450
MPCPALPDGFDFTDPDLLHHRVPLPEFAELRRVEPVTWIAQPPGLAGFQDEGYWAVTRHADVKYVSTHPELYSSYLNTAIIRFNEHIERDAIDAQRLILLNMDPPEHTRVRQIVQRGFTPRAIRALEERLRARAHAIVESARAHSGPFDFVTEVACELPLQAIAELIGVPQDDRAKLFDWSNKMIAYDDPEYAITEEVGKESATELIAYAMNMAADRKQCPAQDIVSTLVAAEDEGNLGSDEFGFFVLMLAVAGNETTRNAITHGMHAFLTHPEQWELYKRERPSTAAEEIVRWATPVASFQRTATQDTELGGKLIRKGDRVGLFYSSANHDPEVFDSPDAFDITRDPNPHLGFGGGGPHFCLGKSLAVLEIDLIFNAIADAMPELRLEGDPRRLRSAWINGVKELRIRAG
>NZ_CP053109.1|WP_171110962.1|6631802_6633857_+|serine-hydrolase
MPTRRDFIARSLGVTAGLAGLPGGISAPRSAELPGGTSVALQAPLIQPWVARHNMTDAQYRAEFHRLERENYRLMDVCGYQAGDQARFAAIWEQRAGPEQFSLHAIPLAEYTREFDLRKENFQLVRLNGYNIAGNVFFAAIWDGRSGAGLKWWSEKNSEPKWWSRHDVPQSELHAVINEREARGYRLVDISAYPGQDFRGTQFAMIWELADGRRWGWIPPRVREYYQRDFEKVLKQEYRPVRVSAFLPGGSGQTAYYTAALEKSVRCPLYARHGIDSRMYQHEVEHQGRTYRPVFVGGFTADYGGGKNATPGFCPIWRRCEADSMVRHLVDAFMKELEVPGLSVAFAQQGGLVYAQGFGLADKDTGEKVTPSSLFRVASVSKTITSAAIMQLTEERELRLTDTVFGERGILGTTFGAQPYGAGIESITVQNLLEHTAGPGWSNKAPDPVQEHPEMNQAELISWVLNERPLNNAAGTAPGAEFDYSNFGYVVLGRIIERVTDQRYDEYVRQHILAPCGITGMRLAGNTRADRRPGEVTYYDQNKEDPYGILITRKDAEGGWLATAVDLMRFVARVDHFAAPPDILTSASVRAMTTPSTAKGANGYAKGWATHPATETWWHTGGVPGSSSVLVRTRHGFCWAALANTRKTDANDRADVGKNTDAALYKLMWDIHDQVDAWPERQNL
>NZ_CP053109.1|WP_171110960.1|6633941_6634358_-|transglycosylase-SLT-domain-containing-protein
MSVSILRRIATPKKALTGIAVAAATAGMALSAAPAHAASGASPAQAKAIAKKMIPDAAQFNAFSKIVQHESNWDIDATNPSSGAYGLVQALPGNKMAAAGSDWKTNAQTQIKWGLDYMKSRYGSPVGAWNFWQANGWY
>NZ_CP053109.1|WP_171110957.1|6634618_6635545_-|ECF-transporter-S-component
MRGPVTKGPVMKGPVHLGPRSLAALAFTTAVGVAAFFWPFLAPPTSQVAAHAQDAPWLFAGLLVLLIAVVAATISESGLGPKAVAMLGVLAATGAALRPIGAGTAGIEPMFFLMVLSGRVLGPGFGFVLGAITMFASALLTGGVGPWMPFQMLAMGWFTMAAGLLPAGDRLRGRAELLLLAAYGFLAAFAYGTIMNLAGWPFMSALASNIAFDPDAPVSANLARFVAYCLATSLGWDLGRAIVTVVLTLTLGPAVLRALRRATRRAAFETPVTFAPPTRSPAGEPSRADGHPDREAPHMTYVTNDPRS

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Crispr_ID: NZ_CP053109_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053109_12

6623330-6623509

Orphan

Consensus_repeat	Method
GCCGACGCCGCGCAGTCCGCCGA	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP053109_12

>merge|NZ_CP053109|12|6623330-6623509|CRISPRCasFinder
GAGGACGCGGCGCGGGCCTCCGAAGCGGCAGCCATCGCACGCCAGGCCGCTGCCGAAGCGACCCAGTGGGCCGAGCTAGCCGAGGGCTACGCCGCCGACGCCGCGCAGTCCGCCGAAGAAGCACGCAAGAACGCCGAGGCCGCCGAAGCTTCCGCGGCCGACGCCGCGCGGTCCGCCGAG

>NZ_CP053109|12|10|6623330-6623509|CRISPRCasFinder
GAGGACGCGGCGCGGGCCTCCGA	AGCGGCAGCCATCGCACGCCAGGCCGCT
GCCGAAGCGACCCAGTGGGCCGA	GCTAGCCGAGGGCTACGCC
GCCGACGCCGCGCAGTCCGCCGA	AGAAGCACGCAAGAACGCCGAGGCCGCCGAAGCTTCCGCG
GCCGACGCCGCGCGGTCCGCCGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053109.1\|WP_171112110.1\|6619230_6619872_-\|IS5/IS1182-family-transposase	unknown	unknown	gnl\|CDD\|372577
NZ_CP053109.1\|WP_171110963.1\|6630392_6631628_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP053109.1\|WP_171110967.1\|6628741_6629020_+\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
NZ_CP053109.1\|WP_171112116.1\|6613484_6614321_-\|nitroreductase	unknown	unknown	gnl\|CDD\|380313
NZ_CP053109.1\|WP_171112112.1\|6618086_6618869_-\|RICIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|379501
NZ_CP053109.1\|WP_171110965.1\|6629003_6630173_-\|steroid-3-ketoacyl-CoA-thiolase	unknown	unknown	gnl\|CDD\|181145
NZ_CP053109.1\|WP_171112111.1\|6618953_6619250_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171110957.1\|6634618_6635545_-\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|378961
NZ_CP053109.1\|WP_171118535.1\|6612468_6613440_-\|patatin-like-phospholipase-family-protein	unknown	unknown	gnl\|CDD\|132848
NZ_CP053109.1\|WP_171112118.1\|6610759_6611248_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171112115.1\|6614460_6615111_+\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224103
NZ_CP053109.1\|WP_171112113.1\|6616019_6618056_+\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|379588
NZ_CP053109.1\|WP_171112117.1\|6611248_6612472_-\|oleandomycin-glycosyltransferase	unknown	unknown	gnl\|CDD\|273616
NZ_CP053109.1\|WP_171110970.1\|6627933_6628782_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262
NZ_CP053109.1\|WP_171110962.1\|6631802_6633857_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP053109.1\|WP_171111843.1\|6626628_6627045_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171111842.1\|6627406_6627787_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP053109.1\|WP_171134089.1\|6624450_6626580_-\|VCBS-repeat-containing-protein	unknown	unknown	gnl\|CDD\|365866
NZ_CP053109.1\|WP_171110960.1\|6633941_6634358_-\|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl\|CDD\|380090
NZ_CP053109.1\|WP_171112114.1\|6615167_6615644_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759

Protein	Function_ID	Function_description	E-value
NZ_CP053109.1\|WP_171112110.1\|6619230_6619872_-\|IS5/IS1182-family-transposase	gnl\|CDD\|372577	pfam13359, DDE_Tnp_4, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	8.80661e-20
NZ_CP053109.1\|WP_171111842.1\|6627406_6627787_-\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	1.99985e-17
NZ_CP053109.1\|WP_171110963.1\|6630392_6631628_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	3.93195e-97
NZ_CP053109.1\|WP_171110967.1\|6628741_6629020_+\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	9.77418e-16
NZ_CP053109.1\|WP_171112116.1\|6613484_6614321_-\|nitroreductase	gnl\|CDD\|380313	cd02136, PnbA_NfnB-like, nitroreductase similar to Mycobacterium smegmatis NfnB. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.	3.73834e-48
NZ_CP053109.1\|WP_171112112.1\|6618086_6618869_-\|RICIN-domain-containing-protein	gnl\|CDD\|379501	pfam14200, RicinB_lectin_2, Ricin-type beta-trefoil lectin domain-like.	2.61622e-20
NZ_CP053109.1\|WP_171110965.1\|6629003_6630173_-\|steroid-3-ketoacyl-CoA-thiolase	gnl\|CDD\|181145	PRK07850, PRK07850, steroid 3-ketoacyl-CoA thiolase.	0
NZ_CP053109.1\|WP_171110957.1\|6634618_6635545_-\|ECF-transporter-S-component	gnl\|CDD\|378961	pfam12822, ECF_trnsprt, ECF transporter, substrate-specific component. Energy-coupling factor (ECF) transporters consist of a substrate-specific component (known as the S component), and an energy-coupling module. The substrate-binding component is a small integral membrane protein which captures specific substrates and forms an active transporter in the presence of the energy-coupling AT module.	9.11379e-15
NZ_CP053109.1\|WP_171118535.1\|6612468_6613440_-\|patatin-like-phospholipase-family-protein	gnl\|CDD\|132848	cd07209, Pat_hypo_Ecoli_Z1214_like, Hypothetical patatin similar to Z1214 protein of Escherichia coli. Patatin-like phospholipase similar to Z1214 protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.	7.106e-43
NZ_CP053109.1\|WP_171112115.1\|6614460_6615111_+\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|224103	COG1182, AcpD, Acyl carrier protein phosphodiesterase [Lipid metabolism].	4.1277e-48
NZ_CP053109.1\|WP_171112113.1\|6616019_6618056_+\|phosphatase-PAP2-family-protein	gnl\|CDD\|379588	pfam14378, PAP2_3, PAP2 superfamily.	1.64951e-42
NZ_CP053109.1\|WP_171112117.1\|6611248_6612472_-\|oleandomycin-glycosyltransferase	gnl\|CDD\|273616	TIGR01426, Glycosyl_transferase, glycosyltransferase, MGT family. This model describes the MGT (macroside glycosyltransferase) subfamily of the UDP-glucuronosyltransferase family. Members include a number of glucosyl transferases for macrolide antibiotic inactivation, but also include transferases of glucose-related sugars for macrolide antibiotic production. [Cellular processes, Toxin production and resistance].	1.19486e-144
NZ_CP053109.1\|WP_171110962.1\|6631802_6633857_+\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.33083e-48
NZ_CP053109.1\|WP_171110970.1\|6627933_6628782_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	8.53963e-09
NZ_CP053109.1\|WP_171134089.1\|6624450_6626580_-\|VCBS-repeat-containing-protein	gnl\|CDD\|365866	pfam00089, Trypsin, Trypsin.	7.70147e-16
NZ_CP053109.1\|WP_171110960.1\|6633941_6634358_-\|transglycosylase-SLT-domain-containing-protein	gnl\|CDD\|380090	pfam18013, Phage_lysozyme2, Phage tail lysozyme. This domain has a lysozyme like fold. It is found in the tail protein of various phages probably giving them the ability to degrade the host cell wall peptidoglycan layer.	5.35459e-05
NZ_CP053109.1\|WP_171112114.1\|6615167_6615644_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	1.78833e-15

>NZ_CP053109.1|WP_171112110.1|6619230_6619872_-|IS5/IS1182-family-transposase
MHCLARDAGISQATCYRYLHEGIGVLAAQAPDLYEALDLCRAEGMTHVVLDGTLIACDRLAGVRENGNDLWSSQKHKSFGGNIQFLAAPDATPLWVSDVEPGSTPDITAAPIHVLPALYKAAADRLPTLADKGYIGAGIGIHVPVRRPKGHSETALDRGTPATNALIRHLRARGERTAAELKERWRALKHVTLSPSRIGDIARAALVLNGQWK
>NZ_CP053109.1|WP_171112111.1|6618953_6619250_+|hypothetical-protein
MTTASVDTNGKRTDAVHDGLGRVIKVWLPGWSKSGHAGQPSAEYTYKVSKTAANAVATKTLRYVRTPPATSSTTARIVLGFSLAGSEVFPVEIISIAR
>NZ_CP053109.1|WP_171112112.1|6618086_6618869_-|RICIN-domain-containing-protein
MNSQLRSRTRTGRPFHTSRVTVPTTAPEILSGVGRSGCPTGCIPARSPSPASAAWSWTSTARTAPRSARGDAGGPVVRAGTAGDELVGVSSRSWQGGCFGSEETRTGAVASRADDLATWVTTAVTAPHTLTNKATGKCLAVPQASTDNGTKLIQWTCTGNSEQQWHLEKVAGGNGDRYRVRNQNSNRCLAIPQAGLDNGTQAIQWTCSGSNDQIWINDSIGRLRNLNSDKCLAIPQANPAIGTGAVQWTCSTNTDQRWTW
>NZ_CP053109.1|WP_171112113.1|6616019_6618056_+|phosphatase-PAP2-family-protein
MANAEHSGRPVGVLGPTVGARLRAARLALWLVATILGVRQIAVVLSTPRGERLTDLETWVGPDGVLHVEGSLYDSTRFTGTPFGGLVLKPLTRSAEQALGWGWTFGTLLLVVVLGLVAARALPPPISRRTSLVAAPVAICLLMLSLPVRNAFWLGQTSIIPVLLVLLGCFAVRGERAGGALIGVAAAFQPTVLLFAPLLWFTGRKKAAASLGVTFASCTALAWAAMPQDSYTYWVHHLAGVGLGGRADDLANQSLHGALLRLGLSGPLEIVLFLVLGAAVATLGLRRAVRYARDGQLLLAVAITGCAAIVVAPTAWQHQLLWVLLAVVGRVGRRASDRLVWPVAVVLVMTLPAKMLLPNMAALHPLRDNVVLLAAIAAATAVPFLSRTSPYYRAPIPTDYAPPVPGRWKHIPLLPFLRRVLGRPNLLLELLLIRVTYAAYSKVRLAATGGTISGGRERAEEHGEQILSLERVLHLDIEHTLNHAIVKVDWLRQFFDFYYTSFHFTIPLTVLAVLYWRRPVDYRWARSTLGLTTLLALIGFWLYPLAPPRLMPDLGIIDTVHGVQDFSQPDYGTLTALTNQYAAMPSLHFGWSLWCGVVIAIVAPKGWMKALGLLHPTLTVTAIVVTGNHWVLDAVGGALVVGAGFGLAYLFQGPRARAVTAVAASPEREPEPTAGKIG
>NZ_CP053109.1|WP_171112114.1|6615167_6615644_-|MarR-family-transcriptional-regulator
MTADVPHRNAASRVTDRPGDTSPFALGLLLRRAHWRAAAVMEEALRPLGIELRHFAVLIVLVERGPTVQRDLVAATGSDKAGIMRVVDDLERKGLAVRKSVPGDRRVRAVEITPAGVELFDAAHVAAEPLAERLVAELGPGEAEQLRELLTRFAHPGS
>NZ_CP053109.1|WP_171112115.1|6614460_6615111_+|NAD(P)H-dependent-oxidoreductase
MATLLHIDSSVLPGEASASRSVAAAFRKAWEEQHPEGTVIHRDLAADPVPHITADAWSAGFTAPSERTPEQAAAFAARVRLIEELEQADAVLIGAPMYNYSIPSTLKAWLDNVILLGRTWGENPSAQGTPVTVVASRGGSYAPGTPREDFEFVQNYLEAVLKRTLGLDVDFIVAELTMAPRNPDMAELIPLYEASRERAFRDATTKAKELAERLAA
>NZ_CP053109.1|WP_171112116.1|6613484_6614321_-|nitroreductase
MDVYEAVRSRRAVRGFTDRHVPREVLERALSAAAWAPSASNLQPWHAYVVTGAPLAELRKRAAERLAAGEPWDEPEYEQYPPALKSPYRERRSAFGEQRYGALGIPREDLEARQRAAAANWDCFGAPAALFCYIDRDMGPAQWSDVGMYLQTVMLLLRAEGLHSCPQMAWAKYHRTVAEVLSPPDEFMLVCGMSIGFEDIRVGCTRTGRAPLGDTVTFVDTVDTADRTRLPTETAAACSPSRAPHGRRRPRVVARLGDGFTRHLGRLASQIGLPPGAG
>NZ_CP053109.1|WP_171118535.1|6612468_6613440_-|patatin-like-phospholipase-family-protein
MIAHERRRTMPSEASPSRDSASAGLHALPRPVAVVVGAGGVLGAAHVGVGYALEERGFVPDMIIGTSVGALNGAIAAAHPDRAAPWLDHVWTRLRRREVYPLGYPSSRAGIFTDRGLRRLIARSGLPSRIEELAVPFTAVAMDLGTGAAALLDHGDLESALLAGAAIPGILPPVDREGRTLVDGGVIAYVPVLAARQAGAASVVVVVTGPESSPLSPTVPRRRAGAIAARARQLMLHHQIERDLHEVSRHIPTVVLPTGVDTWPAPWDFGHTRRLISTASGTAGRFLDGLRVCGPGLYRVEDAPAVPAGPGEPSTSSASGAAL
>NZ_CP053109.1|WP_171112117.1|6611248_6612472_-|oleandomycin-glycosyltransferase
MSTVAFLNIAMHGRVNPTLPVVAELVRRGHSVTYHTSPAFREEIEAVGATVCLYAGGDQPLPDPPTPVTLIEGLAGTAVRLLPAVLADLRRIRPDLIVHDNACPWGAVAARELEVPAASSFTTFAFNRHVPSPTRGSWDLLAAAMARPRRVQGYLRSRWELRRRFDASGLPWVDLGNIRQPLNLVYTSRAFQPAVEEFDQSYRFVGPSIGARPDDPSFPADRLRDPVLYASLGTVFNADPRLLRSFATGLASLGGTVIVSTGQTDPAALGPLPEHVLARRFVPQPEVLARAALFVTHGGMNSVNEAMYAGVPMLVVPQGADQPMVARRIVELGAGLSIRTEDVTEGSVRALAGHLLHEPRFRAAAATLRVAQHEAGGHRRAADELERYLHAAGSVGRPAPVDPSQWG
>NZ_CP053109.1|WP_171112118.1|6610759_6611248_-|hypothetical-protein
MMSLVVFLLLLAGVSEAAGRIVPLAVRRPGMSRPLVAGLLVAGGLVEAAVFTLWPLTAWTLAELVLPSEPPGAGLAWTPDLVAPLVLAAVLAFPLLGPLLHLLLFVGVGAGLAGPLAAATGLGWWGAAGCVAVAGAGLGVAVEAVRRLVVRISATEGRESTA
>NZ_CP053109.1|WP_171134089.1|6624450_6626580_-|VCBS-repeat-containing-protein
MSLPQRHLRRAALLAVGAVLLAPVPVAQAVVGTPAPDDGTFAFTAHLSIGNGARSCSAALVDPEWLVSAASCFAADPQSGTAPAAGKPALKTVATIGRVDLTATDGGHVTEVTHIVPRAGRDLAFARLATPATGITPVKLATTPPAAGDELTALGFGRTKTEWVPDRLHQADFNLDSVADGTLAMTGKTADDSVCKGDTGGPVLRTTGSGSYELVAVNSRSWQGGCHGTTETRTGAVAARADGSPGGATLTAGQTLRPGDSLLSKSAKVTMGTDGNLTVASNAGKTLWSSGTAGHPGATATFSETGNLAVKAADGTTLWESKTSAPGGSAILGDVGDLVVYNAQNQSQWSSNSAPRHDYNGDGRSDMAAWYNFTAGTDNIYTFLAATDGGISTPKRGFTFPVGAWEAKNHKLVTGDFNGDGRGDIAALLGYSDTTVKLWTFLGKPDGTFAEPVEAWSSPAGGPFHKTYMTPQSGDFNGDGRDDIAVWYAYPDGTTKIWTYLSTASGTFNAPTSSWSAPTGTWARTRAKIITGDFNGDGRDDLSVFYGQGDDSIKTYVFNAQPNGGFAAPTVWWRTLALDWNRAYPHSGDFNGDGRDDATIWYDYPDGSDKTSTILSENVDGTDRFGSAKVTLNSPGGLDITRSQLVVGDYNGDGRDDLSIMHHLADDGVKMWTWTARPDTLFNSGLAGYTVPATSWDYTLSRFANTYNY
>NZ_CP053109.1|WP_171111843.1|6626628_6627045_-|hypothetical-protein
MFNGASIATADDVPPVAVEDFAYPDADQIYADTGIRLISGDGHILLADCGPTGLIEVFARNMDMSKFCFSVKGTSGRIAMEVPQVFGIKGNDYQIVADMTVDGTETSYEITRNQWTPVGETADPEARDHTLVELRATQ
>NZ_CP053109.1|WP_171111842.1|6627406_6627787_-|ATP-binding-protein
MSLTVGEHSARHIRRIVRSLLTEWEMPDLADAVELGVTELVANVVRHVPDRRCTLLLVRQKTGARVEVSDGSPQLPCPSTTLSPDAENGRGLVLLDAVADKWGVEPRSGGGKTVWFECESADAPLL
>NZ_CP053109.1|WP_171110970.1|6627933_6628782_+|helix-turn-helix-domain-containing-protein
MTHINVLDPGASPLDYYGYELRRHREAAGLTQRQLGEIVNYTGSLIGQIETARKLPTPAFSERVDAALGTGGLLSRLTELVLRSQLPAWFQQVAELEARAVEICAFQTHMVHGLLQTAAYARGVLGALDQSNLDDRTAVRLARQRIFKKEEPPVFWAILSEAALYQQIGNPETMREQLAHLLSFEGDPRINMQVLPFSVGAHAGLTGSFNLYRFPSDPTIVYTEGYGSGHPTANPDTVKNCSLRYDHLQAAALSLRDSAELIRRVMEERYGEQRDSDGGPVA
>NZ_CP053109.1|WP_171110967.1|6628741_6629020_+|DUF397-domain-containing-protein
MASNAIPTVAQWRKSSYSSDQGGQCVECAPVGLAWRKSTYSSDQGGDCIEIAESPCATIAIRDSKTPTGPMLTVAPAAFTTFVSWSAATAAE
>NZ_CP053109.1|WP_171110965.1|6629003_6630173_-|steroid-3-ketoacyl-CoA-thiolase
MAAEPVIVEAVRTPIGKRGGALANLHPAYLLGETYRELLGRTGIPADCVEQVVGGTVTHAGEQSMNPARTAWLTMGLPYETAATTVDCQCGSSQQASHMTANLIAAGVIDVGISCGVESMSRVPLGSGSKHGPGKPFPDEWNVDLPNQFEAAERIARHRGLTRENVDTLGLLSQQRAANAWSEERFKRETFAVQVPTTEEEQHAGQGMWRLVDRDEGLRDTSMEALSGLKPIMPTAVHTAGNSSQISDGAAAIMWASKRMARALKLKPRARIVAQALVGADPHFHLDGPIDATRAVLGKAGMTLKDIDIVEINEAFASVVLSWAQVFEQDLEKVNVNGGAIALGHPVGATGARLITTALHELERADKEFALVTMCAGGGLATGTIIQRL
>NZ_CP053109.1|WP_171110963.1|6630392_6631628_+|cytochrome-P450
MPCPALPDGFDFTDPDLLHHRVPLPEFAELRRVEPVTWIAQPPGLAGFQDEGYWAVTRHADVKYVSTHPELYSSYLNTAIIRFNEHIERDAIDAQRLILLNMDPPEHTRVRQIVQRGFTPRAIRALEERLRARAHAIVESARAHSGPFDFVTEVACELPLQAIAELIGVPQDDRAKLFDWSNKMIAYDDPEYAITEEVGKESATELIAYAMNMAADRKQCPAQDIVSTLVAAEDEGNLGSDEFGFFVLMLAVAGNETTRNAITHGMHAFLTHPEQWELYKRERPSTAAEEIVRWATPVASFQRTATQDTELGGKLIRKGDRVGLFYSSANHDPEVFDSPDAFDITRDPNPHLGFGGGGPHFCLGKSLAVLEIDLIFNAIADAMPELRLEGDPRRLRSAWINGVKELRIRAG
>NZ_CP053109.1|WP_171110962.1|6631802_6633857_+|serine-hydrolase
MPTRRDFIARSLGVTAGLAGLPGGISAPRSAELPGGTSVALQAPLIQPWVARHNMTDAQYRAEFHRLERENYRLMDVCGYQAGDQARFAAIWEQRAGPEQFSLHAIPLAEYTREFDLRKENFQLVRLNGYNIAGNVFFAAIWDGRSGAGLKWWSEKNSEPKWWSRHDVPQSELHAVINEREARGYRLVDISAYPGQDFRGTQFAMIWELADGRRWGWIPPRVREYYQRDFEKVLKQEYRPVRVSAFLPGGSGQTAYYTAALEKSVRCPLYARHGIDSRMYQHEVEHQGRTYRPVFVGGFTADYGGGKNATPGFCPIWRRCEADSMVRHLVDAFMKELEVPGLSVAFAQQGGLVYAQGFGLADKDTGEKVTPSSLFRVASVSKTITSAAIMQLTEERELRLTDTVFGERGILGTTFGAQPYGAGIESITVQNLLEHTAGPGWSNKAPDPVQEHPEMNQAELISWVLNERPLNNAAGTAPGAEFDYSNFGYVVLGRIIERVTDQRYDEYVRQHILAPCGITGMRLAGNTRADRRPGEVTYYDQNKEDPYGILITRKDAEGGWLATAVDLMRFVARVDHFAAPPDILTSASVRAMTTPSTAKGANGYAKGWATHPATETWWHTGGVPGSSSVLVRTRHGFCWAALANTRKTDANDRADVGKNTDAALYKLMWDIHDQVDAWPERQNL
>NZ_CP053109.1|WP_171110960.1|6633941_6634358_-|transglycosylase-SLT-domain-containing-protein
MSVSILRRIATPKKALTGIAVAAATAGMALSAAPAHAASGASPAQAKAIAKKMIPDAAQFNAFSKIVQHESNWDIDATNPSSGAYGLVQALPGNKMAAAGSDWKTNAQTQIKWGLDYMKSRYGSPVGAWNFWQANGWY
>NZ_CP053109.1|WP_171110957.1|6634618_6635545_-|ECF-transporter-S-component
MRGPVTKGPVMKGPVHLGPRSLAALAFTTAVGVAAFFWPFLAPPTSQVAAHAQDAPWLFAGLLVLLIAVVAATISESGLGPKAVAMLGVLAATGAALRPIGAGTAGIEPMFFLMVLSGRVLGPGFGFVLGAITMFASALLTGGVGPWMPFQMLAMGWFTMAAGLLPAGDRLRGRAELLLLAAYGFLAAFAYGTIMNLAGWPFMSALASNIAFDPDAPVSANLARFVAYCLATSLGWDLGRAIVTVVLTLTLGPAVLRALRRATRRAAFETPVTFAPPTRSPAGEPSRADGHPDREAPHMTYVTNDPRS

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Crispr_ID: NZ_CP053109_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053109_14

7059240-7059474

Orphan

Consensus_repeat	Method
AGGAGGCGGCGTCGGTCAAGAAGGCCGGGGCAAAGAAGGTGGCGTCGGCCAAGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP053109_14

>merge|NZ_CP053109|14|7059240-7059474|CRISPRCasFinder
AGGAGGCTGCGGCATCGAAGGAAGCCGTGGCAAAGAAGGCGGCGTCGGCCAAGGAGGCCGCGGTCGAGGAGGCGGCGTCGGTCAAGAAGGCCGGGGCAAAGAAGGTGGCGTCGGCCAAGGAAGCTGCGGTCGAGGAGGCGGCGGTGTCTGCGCGGGCGGCGGCTGAGGGGACCGTCGCCAAGGAGGCGGCGTCGGTCAAGAAGGCCGGGGCAAGGAAGGTGGCGTCGGCCAAGGA

>NZ_CP053109|14|12|7059240-7059474|CRISPRCasFinder
AGGAGGCTGCGGCATCGAAGGAAGCCGTGGCAAAGAAGGCGGCGTCGGCCAAGGA	GGCCGCGGTCGAGGAGGCGGCGTCGGTCAAGAAGGCCGGGGCAAAGAAGGTGGCGTCGGCCAAGGAAGCTGCGGTCGAGGAGGCGGCGGTGTCTGCGCGGGCGGCGGCTGAGGGGACCGTCGCCA
AGGAGGCGGCGTCGGTCAAGAAGGCCGGGGCAAGGAAGGTGGCGTCGGCCAAGGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053109.1\|WP_171115281.1\|7066221_7067022_-\|DsbA-family-protein	unknown	unknown	gnl\|CDD\|372611
NZ_CP053109.1\|WP_171115278.1\|7067874_7069239_-\|DUF2252-domain-containing-protein	unknown	unknown	gnl\|CDD\|313268
NZ_CP053109.1\|WP_171115285.1\|7063856_7064426_+\|dienelactone-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223489
NZ_CP053109.1\|WP_171115294.1\|7060310_7060973_+\|signal-peptidase-II	unknown	unknown	gnl\|CDD\|237810
NZ_CP053109.1\|WP_171115292.1\|7061044_7061989_+\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|161659
NZ_CP053109.1\|WP_171115309.1\|7049439_7050630_+\|cell-division-protein-FtsZ	unknown	unknown	gnl\|CDD\|236468
NZ_CP053109.1\|WP_171115307.1\|7050626_7051358_+\|peptidoglycan-editing-factor-PgeF	unknown	unknown	gnl\|CDD\|376831
NZ_CP053109.1\|WP_171115280.1\|7067105_7067795_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171115313.1\|7047242_7048340_+\|undecaprenyldiphospho-muramoylpentapeptide-beta-N-acetylglucosaminyltransferase	unknown	unknown	gnl\|CDD\|234825
NZ_CP053109.1\|WP_171115290.1\|7061985_7062453_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|225064
NZ_CP053109.1\|WP_171115302.1\|7052213_7052855_+\|cell-division-protein-SepF	unknown	unknown	gnl\|CDD\|377370
NZ_CP053109.1\|WP_171115298.1\|7054614_7057752_-\|isoleucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235681
NZ_CP053109.1\|WP_171115311.1\|7048366_7049161_+\|FtsQ-type-POTRA-domain-containing-protein	unknown	unknown	gnl\|CDD\|224505
NZ_CP053109.1\|WP_171115315.1\|7045877_7047236_+\|putative-lipid-II-flippase-FtsW	unknown	unknown	gnl\|CDD\|274232
NZ_CP053109.1\|WP_171115287.1\|7062628_7063750_-\|mechanosensitive-ion-channel	unknown	unknown	gnl\|CDD\|366370
NZ_CP053109.1\|WP_007448661.1\|7052935_7053220_+\|YggT-family-protein	unknown	unknown	gnl\|CDD\|376765
NZ_CP053109.1\|WP_171115305.1\|7051364_7052084_+\|YggS-family-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|223402
NZ_CP053109.1\|WP_171115283.1\|7064433_7066095_-\|alkaline-phosphatase-D-family-protein	unknown	unknown	gnl\|CDD\|226070
NZ_CP053109.1\|WP_171115288.1\|7062467_7062623_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171115300.1\|7053273_7054410_+\|DivIVA-domain-containing-protein	unknown	unknown	gnl\|CDD\|377456

Protein	Function_ID	Function_description	E-value
NZ_CP053109.1\|WP_171115281.1\|7066221_7067022_-\|DsbA-family-protein	gnl\|CDD\|372611	pfam13462, Thioredoxin_4, Thioredoxin.	3.43376e-43
NZ_CP053109.1\|WP_171115278.1\|7067874_7069239_-\|DUF2252-domain-containing-protein	gnl\|CDD\|313268	pfam10009, DUF2252, Uncharacterized protein conserved in bacteria (DUF2252). This domain, found in various hypothetical bacterial proteins, has no known function.	4.40349e-136
NZ_CP053109.1\|WP_171115285.1\|7063856_7064426_+\|dienelactone-hydrolase-family-protein	gnl\|CDD\|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	1.05762e-20
NZ_CP053109.1\|WP_171115294.1\|7060310_7060973_+\|signal-peptidase-II	gnl\|CDD\|237810	PRK14764, PRK14764, lipoprotein signal peptidase; Provisional.	1.95289e-93
NZ_CP053109.1\|WP_171115292.1\|7061044_7061989_+\|RluA-family-pseudouridine-synthase	gnl\|CDD\|161659	TIGR00005, Ribosomal_large_subunit_pseudouridine_synthase_D, pseudouridine synthase, RluA family. In E. coli, RluD (SfhB) modifies uridine to pseudouridine at 23S RNA U1911, 1915, and 1917, RluC modifies 955, 2504 and 2580, and RluA modifies U746 and tRNA U32. An additional homolog from E. coli outside this family, TruC (SP\|Q46918), modifies uracil-65 in transfer RNAs to pseudouridine. [Protein synthesis, tRNA and rRNA base modification].	7.85138e-104
NZ_CP053109.1\|WP_171115309.1\|7049439_7050630_+\|cell-division-protein-FtsZ	gnl\|CDD\|236468	PRK09330, PRK09330, cell division protein FtsZ; Validated.	0
NZ_CP053109.1\|WP_171115307.1\|7050626_7051358_+\|peptidoglycan-editing-factor-PgeF	gnl\|CDD\|376831	pfam02578, Cu-oxidase_4, Multi-copper polyphenol oxidoreductase laccase. Laccases are multi-copper oxidoreductases able to oxidize a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms.	1.51965e-83
NZ_CP053109.1\|WP_171115313.1\|7047242_7048340_+\|undecaprenyldiphospho-muramoylpentapeptide-beta-N-acetylglucosaminyltransferase	gnl\|CDD\|234825	PRK00726, murG, undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional.	1.03668e-139
NZ_CP053109.1\|WP_171115290.1\|7061985_7062453_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|225064	COG2153, ElaA, Predicted acyltransferase [General function prediction only].	5.84827e-20
NZ_CP053109.1\|WP_171115302.1\|7052213_7052855_+\|cell-division-protein-SepF	gnl\|CDD\|377370	pfam04472, SepF, Cell division protein SepF. SepF accumulates at the cell division site in an FtsZ-dependent manner and is required for proper septum formation. Mutants are viable but the formation of the septum is much slower and occurs with a very abnormal morphology. This family also includes archaeal related proteins of unknown function.	4.16486e-31
NZ_CP053109.1\|WP_171115298.1\|7054614_7057752_-\|isoleucine--tRNA-ligase	gnl\|CDD\|235681	PRK06039, ileS, isoleucyl-tRNA synthetase; Reviewed.	0
NZ_CP053109.1\|WP_171115311.1\|7048366_7049161_+\|FtsQ-type-POTRA-domain-containing-protein	gnl\|CDD\|224505	COG1589, FtsQ, Cell division septal protein [Cell envelope biogenesis, outer membrane].	6.00368e-23
NZ_CP053109.1\|WP_171115315.1\|7045877_7047236_+\|putative-lipid-II-flippase-FtsW	gnl\|CDD\|274232	TIGR02614, Putative_lipid_II_flippase_FtsW, cell division protein FtsW. This family consists of FtsW, an integral membrane protein with ten transmembrane segments. In general, it is one of two paralogs involved in peptidoglycan biosynthesis, the other being RodA, and is essential for cell division. All members of the seed alignment for this model are encoded in operons for the biosynthesis of UDP-N-acetylmuramoyl-pentapeptide, a precursor of murein (peptidoglycan). The FtsW designation is not used in endospore-forming bacterial (e.g. Bacillus subtilis), where the member of this family is designated SpoVE and three or more RodA/FtsW/SpoVE family paralogs are present. SpoVE acts in spore cortex formation and is dispensible for growth. Biological rolls for FtsW in cell division include recruitment of penicillin-binding protein 3 to the division site. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	5.33689e-135
NZ_CP053109.1\|WP_171115287.1\|7062628_7063750_-\|mechanosensitive-ion-channel	gnl\|CDD\|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	2.3368e-29
NZ_CP053109.1\|WP_007448661.1\|7052935_7053220_+\|YggT-family-protein	gnl\|CDD\|376765	pfam02325, YGGT, YGGT family. This family consists of a repeat found in conserved hypothetical integral membrane proteins. The function of this region and the proteins which possess it is unknown.	0.000237172
NZ_CP053109.1\|WP_171115305.1\|7051364_7052084_+\|YggS-family-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|223402	COG0325, COG0325, Predicted enzyme with a TIM-barrel fold [General function prediction only].	5.74728e-79
NZ_CP053109.1\|WP_171115283.1\|7064433_7066095_-\|alkaline-phosphatase-D-family-protein	gnl\|CDD\|226070	COG3540, PhoD, Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism].	9.99603e-146
NZ_CP053109.1\|WP_171115300.1\|7053273_7054410_+\|DivIVA-domain-containing-protein	gnl\|CDD\|377456	pfam05103, DivIVA, DivIVA protein. The Bacillus subtilis divIVA1 mutation causes misplacement of the septum during cell division, resulting in the formation of small, circular, anucleate mini-cells. Inactivation of divIVA produces a mini-cell phenotype, whereas overproduction of DivIVA results in a filamentation phenotype. These proteins appear to contain coiled-coils.	3.60953e-16

>NZ_CP053109.1|WP_171115298.1|7054614_7057752_-|isoleucine--tRNA-ligase
MTTPTYRQVPAQVDLPALEHAVLDFWREQKIFAKSLEQSEGRPEWVFYEGPPTANGMPGAHHIEARVFKDVFPRFRTMRGYHVARKAGWDCHGLPVELAVEKELGFSGKKDIEAYGIAEFNAKCRESVLRHTDAFAELTTRMGYWVDLDEAYVTMEPEYIESVWWSLKEIFNKGLLVQDHRVAPWCPRCGTGLSDHELAQGYETVVDPSVYVRFPLTSGPLAGDAALLVWTTTPWTLVSNTAVAAHPEVTYVVATNGEEQLVVAEPLVEKALGEGWETTGQTFTGAEMERWTYQRPFELVEFPAPAHFIVNAEYVTTEDGTGLVHQSPAFGEDDLKVCRAYGLPVVNPVRPDGTFEEDLPLVGGAFFKKADEKLTEDLGNRGLLFKHLPYEHSYPHCWRCHTALLYYAQPSWYIRTTAIKDRLLEENERTNWYPDTVKHGRYGDWLNNNIDWALSRNRYWGTPLPIWRCEDDHLTVVGSRAELTELTGTDQSGLDPHRPFIDEVTFACPHCRQTATRVPEVIDAWYDSGSMPFAQWGYPYKNKDLFESRYPAQFISEAIDQTRGWFYTLMAVGTLVFDKSSYENVVCLGHILAEDGRKMSKHLGNILQPIPLMDQHGADAVRWFMAAGGSPWAARRVGHGTIQEVVRKTLLTYWNTVAFQALYARTSNWAPSAADPAPADRPLLDRWLLSELHALTDQVTQSLEAYDTQRAGKLLSAFVDDLSNWYVRRSRRRFWQGDKAALRTLHEVVETVTKLMAPLTPFITERVWQDLIVPVTPGAPESVHLSSWPEADLTAIDPELSKQMVLVRRLVELGRATRAESGVKTRQPLRRALIAATGFAALSPELHTQITEELNVESLASLSEVGGSLVDTTAKANFRALGKRFGKRVQDVAKAIANADAAALSLALREGTASVEVDGETITLAPDEVIITETPREGWSVASDSGATVALDLEITEELRRAGLARDAIRLIQEARKNSGLDVADRIALRWTATDPATIAALGDHATLIADEVLATDFAQGEADDSYGSPFTDEPLTLTFRLRKA
>NZ_CP053109.1|WP_171115300.1|7053273_7054410_+|DivIVA-domain-containing-protein
MPLTPEDVRNKQFTTVRLREGYDEDEVDAFLDEVEAELTRLLRENEDLRAKLAAATRAAAQNQQNMRKPPEGQDQQQGMPQQGGMPQQGMPQQGMRGPGAPVPAGISGPPQQQMGGPMGGPPQLPSGAPQLPAGPGGQGPQGPGPMGQGPMGQGPMQGQMGPGPMGGPMGGPGMPGQGPGGDSAARVLSLAQQTADQAIAEARSEANKIVGEARSRAEGLERDARAKADALERDAQEKHRVAMGSLESARATLERKVEDLRGFEREYRTRLKSYLESQLRQLETQADDSLAPPRTPATASLPPSPAPSMAPAGASAPSYGGNQTMGGGPSPSGPSYGSQQQMSPAMTQPMAPVRPQGPSPMGQAPSPMRGFLIDEDDN
>NZ_CP053109.1|WP_007448661.1|7052935_7053220_+|YggT-family-protein
MSVVLDVVYIALMCFLIVLIFRLVMDYVFQFARSWQPGKAMVVVLEATYTVTDPPLKLLRRFIPPLRLGGVALDLSFFVLMIIVYILISIVSRL
>NZ_CP053109.1|WP_171115302.1|7052213_7052855_+|cell-division-protein-SepF
MAGAMRKMAVYLGLVEDDGYDGRGFDPDDDFEPELDPEPERDHRRHDSSHQSHGAHQSQRDEPVRVVQPPAPREPVSHSASLPAESGRPARIAPVASITQERASLEKNAPVIMPKVVSEREPYRITTLHPRTYNEARTIGEHFREGTPVIMNLTEMDDTDAKRLVDFAAGLVFGLHGSIERVTQKVFLLSPANVDVTAEDKARIAEGGFFNQS
>NZ_CP053109.1|WP_171115305.1|7051364_7052084_+|YggS-family-pyridoxal-phosphate-dependent-enzyme
MTDRKDELARNLGQVEERIAAACAAAGRRREEVTLIVVTKTYPAADVRILSELGVRHVAENRDQDAAPKAAECSDLPLTWHFVGQLQTNKVRSVVGYADLVQSVDRSRLVTALSKEAVRAGREVGCLIQVALDAGESARGERGGVAPSGIGELADLVAGAPGLRLDGLMTVAPLTGEYAGHELAAFERMMDLSTDLRRTHPAATMVSAGMSADLEQAVAAGATHVRVGTAVLGVRPRLG
>NZ_CP053109.1|WP_171115307.1|7050626_7051358_+|peptidoglycan-editing-factor-PgeF
MIGQRDTVNGAHFGFTDRWGGVSAVPYEELNLGGAVGDDPGAVRTNRELAAKSLGLDAGRVVWMNQVHGDDVAVVDGPWDSAEPIPSVDAIVTRHRGLALAVLTADCVPVLLADPVAGVAAAAHAGRPGMVAGVVPAALRAMMELGAEPDRIVARTGPAVCGRCYEVPEAMRAEVAAVEPEAYAETSWGTPAVDVAAGVHAQLARLGVRDRAQSPVCTLESGDHFSYRRDRTTGRLAGYVWLE
>NZ_CP053109.1|WP_171115309.1|7049439_7050630_+|cell-division-protein-FtsZ
MAAPQNYLAVIKVIGVGGGGVNAINRMIEVGLKGVEFIAINTDAQALLMSDADVKLDVGRELTRGLGAGANPAVGRKAAEDHREEIEEVLKGADMVFVTAGEGGGTGTGGAPVVANIARSLGALTIGVVTRPFTFEGRRRANQAEDGIAELREEVDTLIVIPNDRLLSISDRQVSVLDAFKSADQVLLSGVQGITDLITTPGLINLDFADVKSVMSEAGSALMGIGSARGDDRAVAAAEMAISSPLLEASIDGARGVLLSISGGSDLGLFEINEAAQLVSEAAHPEANIIFGAVIDDALGDEVRVTVIAAGFDGGQPPARRDNVLGSSSAKREEPTPVRQTESRPSFGALGSVKPKEEPEPAPEPVSEIQAPPPVPPSRSYAESAAEELDVPDFLK
>NZ_CP053109.1|WP_171115311.1|7048366_7049161_+|FtsQ-type-POTRA-domain-containing-protein
MAGPTTAERGARQQESSGPPLVRRLRRFRLRTIIILAIVLILLGTGAGWLLYGSQWTRVERVTVSGTRVLTPAQVREAADVPVGAPLISVDTDGIEARLRQKLPRIDAVQVVRSWPHGIGLKVTERTPVLLVKKGTKFVEVDDEGVRFATVSEAPKGVPLLELTVSRTGSAVPSHRRFGESRLMREAVRAAGAVPAAVAHQTRVVKVRSYDDISLELSDGRTVAWGSSEKGRAKARTLTALMKAAPGARHFDVSVPTAPASSGS
>NZ_CP053109.1|WP_171115313.1|7047242_7048340_+|undecaprenyldiphospho-muramoylpentapeptide-beta-N-acetylglucosaminyltransferase
MHVVLAGGGTAGHIEPALALADALRRQDPTVGITALGTERGLETRLVPERGYELALIPAVPLPRKPTPELITVPGRLRGTIKAAEQILERTKADAVVGFGGYVALPGYLAAKRLGVPIVVHEANARPGLANKIGSRYAAQVAVSTPDSKLRGARYIGIPLRRAIATLDRAAARPEARHMFGLDPNLPTLLVSGGSQGARRLNEVVQQVAPYLQQAGIQILHAVGPKNELPQVHQMPGMPPYIPVSYLDRMDLAYAAADMMLCRAGAMTVAELSAVGLPAAYVPLPIGNGEQRLNAQPVVKAGGGLLVDDAELTPEWVQQNVLPVLADPHRLYEMSRAAGEFGRRDADELLVGMVYEAIAAHRAHR
>NZ_CP053109.1|WP_171115315.1|7045877_7047236_+|putative-lipid-II-flippase-FtsW
MSGSRTGRPPVPRTVRAPAAPRPPRENPFVRFSTRAKRAWDRPLTAYYLILGGSLLITVLGLVMVYSASQITALQMSLPGSYFFRKQMLAAVIGAVLLYVACRMPVKLHRALAYPILAGAVFLMALVQVPGIGLAVNGNQNWIALGGSFQIQPSEFGKLALVLWAADLLARKQERNLLAQWKHMLVPLVPMAFLLLGLIMLGGDMGTAIILTAILFGLLWLAGAPTRLFVGVLGVAAALGAILIQSSSNRLGRFRCIGATEMGPDGSCWQAVHGIYALASGGLFGSGLGASVEKWGQLPEAHTDFIFAVTGEELGLAGTLSVLALFAALGYAGIRVAGRTEDPFVRYAAGGVTTWITAQAVINIGAVLGLLPIAGVPLPLFSYGGSALLPTMFAIGLLIAFARDEPAARAALAMRQPRFGRKRGAGGTASNRSPRSWNTMRRRATARSSGER
>NZ_CP053109.1|WP_171115294.1|7060310_7060973_+|signal-peptidase-II
MAEAERIIGMPGTPDAARAEQERPGDDAASQERSGAEAAAAAAGASGTDERDAPAERPRGKRRIAVLFAVAGFAYALDLISKMIVVAKLEHHEPIEVIGDWLRFEAIRNAGAAFGFGEAFTVIFTVIAAAVIVVIARLARKLYSLPWAIALGLLLGGALGNLTDRIFRSPGVFQGAVVDFIAPKHFAVFNLADSAIVCGGILIVLLSFKGLDPDGTVHKD
>NZ_CP053109.1|WP_171115292.1|7061044_7061989_+|RluA-family-pseudouridine-synthase
MSTIPEIRTLPVPDGLEGERVDAAISRMFGFSRTKAAELAAAGKVLVDGTAVGKSERVRGGAWLEVEMPQAAPPVQVVAEPVEGMEIVHDDEDVVVIVKPVGVAAHPSPGWTGPTVIGGLAAAGYRISTSGAAERQGIVHRLDVGTSGLMVVAKSERAYTSLKRQFKQRTVDKRYHTLVQGHPDPTSGTIDAPIGRHPNHDYKWAVTADGKPSVTHYDLIEAFRAASLLDVKLETGRTHQIRVHMAAHRHPCVGDLTYGADPTLAKRLRLTRQWLHAVRLGFEHPGDGEWVEFACDYPDDLQSALDKVREETYG
>NZ_CP053109.1|WP_171115290.1|7061985_7062453_+|GNAT-family-N-acetyltransferase
MSPGYVVRVAEEEADREACFAVRKEVFVAEQGVPEDVEYDAYDAGALHVLAVREDGVPLGTGRLLYGAAAAAKTGGDPSVGSLGRLAVTREARGLGVGGALVRAIEDAARARGLSAVDLHAQTHALGFYERLGYVAYGPEFPDAGIPHRAMRRSL
>NZ_CP053109.1|WP_171115288.1|7062467_7062623_-|hypothetical-protein
MADNNRTSRTSTTTPTIAAGQPSSSPHRPDAVRIASSSASTMPTLNGQDRR
>NZ_CP053109.1|WP_171115287.1|7062628_7063750_-|mechanosensitive-ion-channel
MENLLRPLIVIGGSVGLGLLIGWATDRLLRKADERHPETPLWGLLRRGRIPYQLVLCAALLRASYDEAQLLQDHRVGVGQTLTLVMIGSAAWLVIRIAAAVVETSYTRYASSRAQRDPARVRRVRTQVTLIMRVVAAVVGVVAIAAMLLTFPAFRAAGASLLASAGILGIVAGVAAQSTLSNMFAGLQIAFGDMVRIGDTVVVDGEWGTVEEITLTYLTVRTWDERRITMPVSYFTSKPFENWSRGSPQMTGIVYWHLDHTAPVEAMREQLRDILRECPAWDGRHYGVDVTDTTPNTMEVRALVTAKDADDVWKVRVTVRERMIAWLIREHPYALPRVNTADALLPPGSTPHRPSPDGTPQRRAVDTPRPDRG
>NZ_CP053109.1|WP_171115285.1|7063856_7064426_+|dienelactone-hydrolase-family-protein
MNIMLFHSTYGLRPAVRAAADRLRTAGHEVWTPDLFEGRTFETAEDGMAFKEEIGKDELLKRAVLAAAPYSERGLVYAGFSFGASVAQTLALGDEKARGLLLLHGTSDLAPNVSVDDLPVQLHVAEPDPFETDDWLSAWYLQMRRAGADVEIYRYAGAGHLYTDTDLPDYDEEAAEATWRVALGFLDSL
>NZ_CP053109.1|WP_171115283.1|7064433_7066095_-|alkaline-phosphatase-D-family-protein
MTSRNRPITGLNFPAPRRRTVVKAAAAGAVLAAPLAGALPARAATETPAFLHGVASGDPLPDGILLWTRVTPTAEATPGSGLGPDTEVSWIVARDKAFTNIVAKGSTTATAASDHTVKADIRGLAPATDYWFRFSAGGTDSPAGRARTAPATDAAVAGLRFGVVSCANWEAGYFAAYRHLAARGDLDAWLHLGDYIYEYAAGEYGTRGTSVRAHAPAHEILTLADYRVRHGRYKTDPDLQALHAAAPVVAIWDDHEIANDAWSGGAENHTEGAEGTWAARQAAAKQAYFEWMPVRPAVAGTTYRRLRFGKLADLSLLDLRSFRSQQAAFGNGDVDDPDRTLTGRAQLDWLKAGLKSSDTTWRLVGNSVMISPFAVGSLSAELLKPLAKLLGLPQEGLAINTDQWDGYTDDRRELLAHLRSNAIRNTVFLTGDIHMAWANDVPVNAGTYPLSASAATEFVVTSVTSDNLDDLVKVPEGTVSAVASPIIRAANRHVHWVDTDRHGYGVLDITAERAQMDYYVLSNRTKADATASWSRSYRTRSGTQKVERTYDPV
>NZ_CP053109.1|WP_171115281.1|7066221_7067022_-|DsbA-family-protein
MSKRNSQAAKTAARERLRAEREREAKRAKVRRQIIVACSVVGVLAVAGGIGYAVVQTNQPSKWEEAADAKVVAPANTSGKNGTTVLIGDSKSDNVVHLYEDPRCPACASFEQTIGETVDKGMEDGAYKLSFTIGTFLDGNLGGEGSKNALSALGAALNVSPEAFLDYKAALYSAEYHPQESTDEFAKDSYLIKVANTVDALKNNKKFQDAVEQGTYDAWAMKMSDSFDNTKDVKSTPTIKINDKVIQNPSTVAEWETALKDAGVTK
>NZ_CP053109.1|WP_171115280.1|7067105_7067795_-|hypothetical-protein
MDISRTQLRAVRAALFTAIVVTLSTASHVLLSRAPLPLGTVAAIAAAVFVIAYALAGRERGFGRIAALLIPLELAADTVFTTGQHACYGRAGGPVAGPLRSVGLDVLCGGEVGTPLARMAGTSGTDRIAAVLAHAHPSTAWLLLGAHVGVGLLAAAWLRRGERALAQLLSAMAATTFRPLLLAAAAGTARPSAPAPRLPRPAHRTAPARDLLLTHSLGRRGPPCSLALV
>NZ_CP053109.1|WP_171115278.1|7067874_7069239_-|DUF2252-domain-containing-protein
MSFPQLNDEQRGEEILAVFGTAFGELLAADPAAFRVKFRKMAASAFAFYRGTACLFYHDLDAENAEENAERAGGTIYGGPFLDERTSRVWIHGDLHAENFGTYMDSNGRLIFNVNDFDEAYVGPFTWDLKRFAASIALIGYAKALSDEQITELVTIYATAYRERVHALATGAKSDEVPPFTLDTAEGPLLDALRDARSLTRFGLLDSMTEIRDFERRFAAGGGSIELDAATRYKVLAAFDGYLETLPESSLARPDSYRVKDVVGRRGIGIGSAGLPSYNILLEGNSDALENDVVIYVKQAQTPAVSRHITDPAIREYFQHEGHRTVISQRALQAHADPWLGWTELDGAGQLVAEVSPYAVDLDWGDIDDPEEIAAVVADLGRATATMHSAADDDSGHSDLVPFSTERAIDAAIAADEEGLAPLLVDFAHSYGARARADHQIFVDLFRNGRIPGL

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Crispr_ID: NZ_CP053109_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053109_15

9198050-9198131

Orphan

Consensus_repeat	Method
GCCTGGCGTCAGCCCGACGCCTGGCGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP053109_15

>merge|NZ_CP053109|15|9198050-9198131|CRISPRCasFinder
CGCGCGGCTCAGCCCGACGCCTGGCGTCACCGCGGCGCCCGGTGTCACCCCCGATGCCCGGCGTCAGCCCGACGCCTGGCGT

>NZ_CP053109|15|13|9198050-9198131|CRISPRCasFinder
CGCGCGGCTCAGCCCGACGCCTGGCGT	CACCGCGGCGCCCGGTGTCACCCCCGAT
GCCCGGCGTCAGCCCGACGCCTGGCGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053109.1\|WP_171134128.1\|9204760_9206734_-\|alpha-1,4-glucan--maltose-1-phosphate-maltosyltransferase	unknown	unknown	gnl\|CDD\|200482
NZ_CP053109.1\|WP_171116036.1\|9188725_9189184_-\|cyclic-nucleotide-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|237999
NZ_CP053109.1\|WP_171116054.1\|9199379_9201617_-\|1,4-alpha-glucan-branching-enzyme	unknown	unknown	gnl\|CDD\|235445
NZ_CP053109.1\|WP_171116052.1\|9198183_9199272_-\|glutamate--cysteine-ligase	unknown	unknown	gnl\|CDD\|237408
NZ_CP053109.1\|WP_171116038.1\|9190612_9190834_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171118967.1\|9187506_9188718_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP053109.1\|WP_171116050.1\|9195542_9197447_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|341233
NZ_CP053109.1\|WP_171116040.1\|9191166_9191610_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP053109.1\|WP_171116046.1\|9194390_9194762_+\|PRC-barrel-domain-containing-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171108845.1\|9210116_9210917_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319911
NZ_CP053109.1\|WP_171116042.1\|9191794_9192646_+\|SigB/SigF/SigG-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274373
NZ_CP053109.1\|WP_171116048.1\|9194807_9195242_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP053109.1\|WP_141310848.1\|9197600_9197834_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053109.1\|WP_171111455.1\|9210984_9211374_+\|ANTAR-domain-containing-protein	unknown	unknown	gnl\|CDD\|198080
NZ_CP053109.1\|WP_171108851.1\|9206803_9207100_-\|DUF5133-domain-containing-protein	unknown	unknown	gnl\|CDD\|375043
NZ_CP053109.1\|WP_171134127.1\|9203033_9204752_-\|maltose-alpha-D-glucosyltransferase	unknown	unknown	gnl\|CDD\|274140
NZ_CP053109.1\|WP_171116044.1\|9192734_9194111_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NZ_CP053109.1\|WP_171108847.1\|9207908_9210092_+\|glycogen-debranching-protein-GlgX	unknown	unknown	gnl\|CDD\|131155
NZ_CP053109.1\|WP_171108849.1\|9207399_9207912_+\|pep-a2	unknown	unknown	unknown
NZ_CP053109.1\|WP_171116056.1\|9201622_9203005_-\|maltokinase	unknown	unknown	gnl\|CDD\|237794

Protein	Function_ID	Function_description	E-value
NZ_CP053109.1\|WP_171134128.1\|9204760_9206734_-\|alpha-1,4-glucan--maltose-1-phosphate-maltosyltransferase	gnl\|CDD\|200482	cd11344, AmyAc_GlgE_like, Alpha amylase catalytic domain found in GlgE-like proteins. GlgE is a (1,4)-a-D-glucan:phosphate a-D-maltosyltransferase, involved in a-glucan biosynthesis in bacteria. It is also an anti-tuberculosis drug target. GlgE isoform I from Streptomyces coelicolor has the same catalytic and very similar kinetic properties to GlgE from Mycobacterium tuberculosis. GlgE from Streptomyces coelicolor forms a homodimer with each subunit comprising five domains (A, B, C, N, and S) and 2 inserts. Domain A is a catalytic alpha-amylase-type domain that along with domain N, which has a beta-sandwich fold and forms the core of the dimer interface, binds cyclodextrins. Domain A, B, and the 2 inserts define a well conserved donor pocket that binds maltose. Cyclodextrins competitively inhibit the binding of maltooligosaccharides to the S. coelicolor enzyme, indicating that the hydrophobic patch overlaps with the acceptor binding site. This is not the case in M. tuberculosis GlgE because cyclodextrins do not inhibit this enzyme, despite acceptor length specificity being conserved. Domain C is hypothesized to help stabilize domain A and could be involved in substrate binding. Domain S is a helix bundle that is inserted within the N domain and it plays a role in the dimer interface and interacts directly with domain B. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NZ_CP053109.1\|WP_171116036.1\|9188725_9189184_-\|cyclic-nucleotide-binding-domain-containing-protein	gnl\|CDD\|237999	cd00038, CAP_ED, effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels.	5.78836e-20
NZ_CP053109.1\|WP_171116054.1\|9199379_9201617_-\|1,4-alpha-glucan-branching-enzyme	gnl\|CDD\|235445	PRK05402, PRK05402, 1,4-alpha-glucan branching protein GlgB.	0
NZ_CP053109.1\|WP_171116052.1\|9198183_9199272_-\|glutamate--cysteine-ligase	gnl\|CDD\|237408	PRK13517, PRK13517, glutamate--cysteine ligase.	2.96316e-151
NZ_CP053109.1\|WP_171111455.1\|9210984_9211374_+\|ANTAR-domain-containing-protein	gnl\|CDD\|198080	smart01012, ANTAR, ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.	4.85214e-13
NZ_CP053109.1\|WP_171116050.1\|9195542_9197447_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|341233	cd05907, VL_LC_FACS_like, Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases. This family includes long-chain fatty acid (C12-C20) CoA synthetases and Bubblegum-like very long-chain (>C20) fatty acid CoA synthetases. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Drosophila melanogaster mutant bubblegum (BGM) have elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene later named bubblegum. The human homolog (hsBG) of bubblegum has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.	0
NZ_CP053109.1\|WP_171116040.1\|9191166_9191610_+\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	7.83854e-10
NZ_CP053109.1\|WP_171108845.1\|9210116_9210917_-\|VOC-family-protein	gnl\|CDD\|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	4.61358e-22
NZ_CP053109.1\|WP_171116042.1\|9191794_9192646_+\|SigB/SigF/SigG-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274373	TIGR02980, SigBFG, RNA polymerase sigma-70 factor, sigma-B/F/G subfamily. This group of similar sigma-70 factors includes clades found in Bacilli (including the sporulation factors SigF:TIGR02885 and SigG:TIGR02850 as well as SigB:TIGR02941), and the high GC gram positive bacteria (Actinobacteria) where a variable number of them are found depending on the lineage.	1.18757e-100
NZ_CP053109.1\|WP_171116048.1\|9194807_9195242_-\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	5.93754e-19
NZ_CP053109.1\|WP_171118967.1\|9187506_9188718_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.30679e-57
NZ_CP053109.1\|WP_171108851.1\|9206803_9207100_-\|DUF5133-domain-containing-protein	gnl\|CDD\|375043	pfam17196, DUF5133, Protein of unknown function (DUF5133). This protein of unknown function is part of the Borrelidin synthesis genomic cluster. Borrelidin is a polyketide antibiotic.	3.39293e-16
NZ_CP053109.1\|WP_171134127.1\|9203033_9204752_-\|maltose-alpha-D-glucosyltransferase	gnl\|CDD\|274140	TIGR02456, Trehalose_synthase, trehalose synthase. Trehalose synthase interconverts maltose and alpha, alpha-trehalose by transglucosylation. This is one of at least three mechanisms for biosynthesis of trehalose, an important and widespread compatible solute. However, it is not driven by phosphate activation of sugars and its physiological role may tend toward trehalose degradation. This view is accentuated by numerous examples of fusion to a probable maltokinase domain. The sequence region described by this model is found both as the whole of a trehalose synthase and as the N-terminal region of a larger fusion protein that includes trehalose synthase activity. Several of these fused trehalose synthases have a domain homologous to proteins with maltokinase activity from Actinoplanes missouriensis and Streptomyces coelicolor (). [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NZ_CP053109.1\|WP_171116044.1\|9192734_9194111_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	2.3003e-94
NZ_CP053109.1\|WP_171108847.1\|9207908_9210092_+\|glycogen-debranching-protein-GlgX	gnl\|CDD\|131155	TIGR02100, Glycogen_operon_protein_GlgX_homolog, glycogen debranching enzyme GlgX. This family consists of the GlgX protein from the E. coli glycogen operon and probable equivalogs from other prokaryotic species. GlgX is not required for glycogen biosynthesis, but instead acts as a debranching enzyme for glycogen catabolism. This model distinguishes GlgX from pullanases and other related proteins that also operate on alpha-1,6-glycosidic linkages. In the wide band between the trusted and noise cutoffs are functionally similar enzymes, mostly from plants, that act similarly but usually are termed isoamylase. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NZ_CP053109.1\|WP_171116056.1\|9201622_9203005_-\|maltokinase	gnl\|CDD\|237794	PRK14705, PRK14705, glycogen branching enzyme; Provisional.	1.55254e-72

>NZ_CP053109.1|WP_141310848.1|9197600_9197834_+|hypothetical-protein
MSHTNPDPEPDRSTGLEPGGSVPPGETPPAESSMPGALPRETHNPPKGWAKAPLTLIIVVAVLVAAFFLAYGLMLML
>NZ_CP053109.1|WP_171116050.1|9195542_9197447_-|long-chain-fatty-acid--CoA-ligase
MRDFALAPPTVSSMTGGLADSLFETAADNPTLPLIARRPDPSATEWEEVTAIELRDEVVDLAKGLVASGITPGHRVAIMARTRYEWTVLSYALWAVGAEVVPIYPTASRDQVEWILRDANCVAVVVEDEQGVMTVGPVCARLPMLRHVWQLDAGALQELAERGEFLPALTVDSLRRIVLPDSTAVIAYTSGTSGRPLGCALSHRGLASPCDILLAGWRQTAAPPGEQGRVLAFLPFSHAYGLMIQGLCIRGGLLMAHEPNLGQEALASALRSFRPTYFYAVPSVFEKMYKNFLRTAQQAGRGALFERAAETARAFAAATERQRLGRGSGPGLELRLHHALYERTVYRRLRAALGGQVCRGTSGGSPLHRELSLFYEGIGIYVHDGYGLTETCGGVTMQPLGREKSGTVGQALPGTEIRLADDGEILVRGPSVFQGYINDEAATRAALWGGWLATGDLGRLDSEGYLTITGRKKDIIITSSGKSVAPAALEQRLRMHPLIHQAVVVGDDRPCVGALITLDPEFLAHWRAALALPGDAPVREAREENALREEVARAVAAANSAVSRSESIRVFRVLPEPFDVTNGLLTPSMKLRRDAIVRHYAAEIDAMYEARSRPPRLAAPEEPAGWDDSDDVFR
>NZ_CP053109.1|WP_171116048.1|9194807_9195242_-|ATP-binding-protein
MATEPRWDETLAGQGIPSRTAGFAGVRQDVTGARLAAEGFLRDLARSAPPATPESWHDILLVVTELAANAVQYAPGPFHLRIRRTYDGVHITVHDTSSTPPAPRPFHPNTGGGGIGWHLIQTLCDQVSVVSDDHGKDIHVFLPW
>NZ_CP053109.1|WP_171116046.1|9194390_9194762_+|PRC-barrel-domain-containing-protein
MTIDRIWSYAPGTGHVEGQDLTGFTVDGTDGTLGRVDRLADPHGMSHLVVDTGVWVFGRSVLVPVGLVTGIDTEHRTVSLACTKSEVKAAPRFRTDSETLDPHYLTTVGDYYTHLPPGEPSTA
>NZ_CP053109.1|WP_171116044.1|9192734_9194111_-|NAD(P)/FAD-dependent-oxidoreductase
MDIVTRPRILVVGAGFAGVGCVRRLERRLAPDEASVTLVTPYSYQLYLPLLPQVASGVLTPQSIALSLRRSRKYRTRIIPGGAIGVDLKAKICVIRTITDEIVNERYDYIVLAPGSVTRTFDIPGLVDNAFGMKTLAEAAYIRDHVISQLDLADASHDPAERTSRLQFVVVGGGYAGTETAACLQRLTRNAVKRYPRLDPRLIRWHLIDIAPKLMPELGEKLGRSAQEVLRRRGIEVSLGVSIKQAGPHEVTFTDGRVVPTRTLIWTAGVVASPLIATLGAETVRGRLAVASEMNLPGHDGVFAVGDAAAVPDRAKDEEGAICPPTAQHAMRQGKRVADNVIATLRNQPMQPYVHKDLGLVVDLGGRDAVSKPLGIELHGLPAQAVARGYHWGALRTNVAKTRVMTNWLLNAVAGDDFVRTGFQARRPAKLKDSEYTDSYLTPEQVRAHVEGAGPVQG
>NZ_CP053109.1|WP_171116042.1|9191794_9192646_+|SigB/SigF/SigG-family-RNA-polymerase-sigma-factor
MLIDMSTSRPGTPDSSASPAHARRRHDDAPETADLFARLHALEDGPERDAVRDELVAAWLPMAHRIAGRFRDRGESLEDLRQVAALGLVKAIDRYDPTRGAFESYAVPTITGEVKRHFRDRMWALRVPRRVQELRNKVRLARRELTQNPGAPEPTVADMAAHTGLTEDEVSTGVEALESFSTLSLDAELSSDDDGYSLADTLGAPDGSYDVVVDRESAKQSLRNLPERERAILYMRFFEDMTQSRIADRLGISQMHVSRLISRSCARVRDEALGHRPPGSAAA
>NZ_CP053109.1|WP_171116040.1|9191166_9191610_+|ATP-binding-protein
MSAQQWTAPEGEPAGQVRPGRGGGCRPADVRRAVRHAVAGRCRATGNPCDEERLSDALLVASELTTNAILHGGGITGVDVDVVGHEVRVSVSDRSDRLPVVVAPVDEEGRRRTGGRGWPIVCRLACDVRVADLPTGGKRITAAVPVF
>NZ_CP053109.1|WP_171116038.1|9190612_9190834_-|hypothetical-protein
MTDVVDSDELLRRIQRGRACAEQEERSWRARSEALEPTDPAGAREAAVRRLAYEAVLRVLDEILTPGRHAEVG
>NZ_CP053109.1|WP_171116036.1|9188725_9189184_-|cyclic-nucleotide-binding-domain-containing-protein
MTRATKLLPALPPPQRERLMTLAREVSFPEDSRIFEAGGTADRFWVIRSGAVSLDQQVTSVQRVTVASLGAGDLLGWSWLFPPHQWDFGAEAFSPVRAYEFEAGPVLALCEQDPQLGMSLVRIVAEILAYRLEMTRGQLMEQYTMHRRGGSH
>NZ_CP053109.1|WP_171118967.1|9187506_9188718_+|MFS-transporter
MDTRPLRRPAYRRLWASTVVTAVGSQLTAVAVPKQIYDITGSSAWVGYASLAGLLPLVVFALWGGAVADSMDRRKLLLITNSGIAVTSVLFWLQAATGLDSVAVLMVLLAAQQAFFGLNAPARSASIARLVPEHELAAANALGSTVMQTGLVAGPLLAGALIPVIGLPELYLIDALALCFAVWAVLRLPALPPLAATVTRRAGVREIVAGFRYIALHKVLLLSFLADVVAMVLGMPRALFPQLAAQTYAPYGEGLALGLLFAAIPIGAVAGGLFSGTFSRARRHGWMVIGAVVAWGVAVTGFGLSASLWVAVAFLAAAGVADMVSMVFRGAILLSAATDEMRGRMQGVFTVVVAGGPRLADALHGTAGSAFGARTAVVGGGVLVVAVMLTLAAAVPDLRRYRV
>NZ_CP053109.1|WP_171116052.1|9198183_9199272_-|glutamate--cysteine-ligase
MRTVGVEEELLLVDPESGEPRARSAAVLARAAHDHADGFVFEKELHDQMLEFNTHPQTDMADLGAEIVRCREEAARNAGEIGCSVAALATSPLPVKPAVGAHYRYQWMAQEYGIATQEQLVLGCHVHVAVESDEEGVAVIDRVRPWLAVLSALSANSPYWQGKDTSYSSYRSRVWQRWPSAGPTELFGSAERYRRRVADMMATGTLLDEAMVYFDARLSRNYPTVEVRVADVCLHADTAVLIAALVRGLVETAAREWRAGRGPAEHSVSVLRLAAWRAARSGLTGELLHPAVMRAAPAETVVRALLEHVGDALKDTGDLARAQDSCAELLRRGNGARVQRELLARTGSLRDVVLQCTRHTQG
>NZ_CP053109.1|WP_171116054.1|9199379_9201617_-|1,4-alpha-glucan-branching-enzyme
MALRDITPPKRPGPLPSARTPGGSAPEPDPADRERLLAGAHHDPHALLGAHPVPGGIAVRALRPFASAVSVLTDGKRVALTSEGDGLFSAVLPMKTIPDYTLLVAYGEDEYEVHDPYRFLPALGELDLHLIREGRHEQLWQALGAEPMTHQGVTGTRFTVWAPNARGVRVAGDFCHWDGTAFPMRSLGASGVWELFLPGIGEGTRYKFEITSQYGHRFLKADPMARRTEVPPDTASIVTASHYEWGDQEWMAHRGDRPVHQAPFSVYEVHLPSWRPGLTYRQLAEELPQYVKDLGFTHVELMPVAEHPFGGSWGYQVTGFYAPTARLGSPDDFRYFVDACHRAGIGVIMDWVPAHFPKDDWALARFDGDALYEPGNAQRAEHPDWGTYEFDFGRTEVRNFLVANAVYWCEEFHIDGLRVDAVASMLYLDYSRESGQWTPNVHGGREDLDAVAFLQEMNATVYRRAPGVVTIAEESTAWGGVTRPTDSGGLGFGLKWNMGWMHDSLEYMSKDPIHRKYHHHEMTFSMIYAYSENYVLPISHDEVVHGKQALVTKMPGDWWQRRANHRAYLGFMWAHPGKQLLFMGQEFAQGGEWSQEHGPEWWLLEPGYCAAGDHRGVQDLVRDLNARYLATPALWQRDTDPGGFQWVECDAADDNVFAFLRYDEQGSPLLAISHFSPAVRHDYRIGVPGDVPAWQEILNTDASRYGGGDITHPDPVKAEAQESHGRPASIRLTLPPLATVWLRPA
>NZ_CP053109.1|WP_171116056.1|9201622_9203005_-|maltokinase
MTKTASLLPSDSGLTASMSSLDGLLREWLPRQRWFAGKDRPVTDLRLLSLTELFPGCLHLLVHAGHAGGHSALAGVPSPWGTPPPGDCYQLFLGVREHPSPRLGRALIGQAQDGPLVGMTVYDALQDLRSAQLLLERLRHPGTAGPLRFEADPAKPVPAGLVPRVLDAEQSNSSLVYGDEFILKVFRRIQPGINPDLEVPGALAGQGCDRVPAPVAWFHTTQPQEATLGVLQPFLRNASDGWTLALHALATGSDFTAEARALGRATAEVHLALAAAFTAGGRCENGRMAAAMTERLDAAAHSVPALRPFVPGLRSAFSALLTCDAGPPAQRIHGDLHLGQVLRAGREWFVIDFEGEPSRPLAERRSAQSPVRDIAGMLRSFDYAARQRRPWRPQWARRCREAYCAGYAARAGWDPRKKHGLLRAYETDRAVYEALYEARHRPDWLPVPMAAIERLAVRGD
>NZ_CP053109.1|WP_171134127.1|9203033_9204752_-|maltose-alpha-D-glucosyltransferase
MTVNEPVPDTFEDTPAKDRDPQWFKRAVFYEVLVRSFQDSNGDGVGDLKGLTAKLDYLQWLGVDCLWLPPFFKSPLRDGGYDVSDYTAVLPEFGDLADFVEFVDAAHQRGIRVIIDFVMNHTSDQHPWFQESRRDPDGPYGDYYMWADDDKQYQDARIIFVDTEVSNWTFDPVRKQYFFHRFFSHQPDLNYENPAVQEEILAALRFWLDLGIDGYRLDAVPYLYAEEGTNCENLPATHEFLQRVRREIDALYPDTVLLAEANQWPEDVVDYFGDYTSGGDECHMAFHFPVMPRIFMAVRRESRYPVSEILAKTPAIPSGCQWGIFLRNHDELTLEMVTDEERDYMYAEYAKDPRMRANIGIRRRLAPLLDNDRHTIELFTALLLSLPGSPILYYGDEIGMGDNIWLGDRDAVRTPMQWTPDRNAGFSTCDPGRLTLPTIMDPVYGYQVTNVEASMASPSSLLHWTRRMIEIRKQNPAFGLGSYTELQSSNPAVLAFLREYEDDLVLCVSNFARFAQPTELDLREFAGRHPVELFGGVRFPAIGELPYLLTLGGHGFYWFRLVRVASRIGRRL
>NZ_CP053109.1|WP_171134128.1|9204760_9206734_-|alpha-1,4-glucan--maltose-1-phosphate-maltosyltransferase
MSMTEAIGRIPVRDVHPAVDCGRRPAKAVPGETFQVTATVFREGHDAVAANVVLRDPQGRPGPWTPMRELAPGTDRWGADVTPDAVGLWTYSVEAWSDPITTWRRVAGIKVPAGIDTGLVLEEGAGLYERAAADVPDRAAREVVLAAARTLRDDSLPIATRLAAALTPEVDAVLAVYPLRELVTASEPLPLLVERERALFGSWYEFFPRSEGTPERPHGTFRTAARRLAAIAAMGFDVVYLPPIHPIGSTFRKGPNNTLSAGPDDVGVPWAIGSPEGGHDAVHPDLGTLEDFDWFVTQAKSHGLEIALDFALQCSPDHPWVDKHPDWFHHRPDGSIAHAENPPKKYQDIYPIAFDRDMDGLVTETLRVLRHWMAHGVRVFRVDNPHTKPVMFWERVIADVNRTDPDVIFLAEAFTRPAMMHTLAQIGFQQSYTYFTWRNTKQELTEYLTELSGEAAAYMRPNFFVNTPDILHAYLQHGGRPAFEARAVLAATLSPTWGVYSGYELCENTPLREGSEEYLDSEKYQLKPRDWDDPNSIAPLITQLNTIRRNHPALRRLRNLRFHHTDNDALIAYSKRTGSDTVLVVVNLDPHHTQEATVSLDMPHLGLDWHDSVSVRDELTGETYQWGSTNYVRLEPGRAPAHVLHVQWPPVSPQNGG
>NZ_CP053109.1|WP_171108851.1|9206803_9207100_-|DUF5133-domain-containing-protein
MLLPARAEVTRQLRRYRAWERAMLAAPADSAVRTGFEDSGYTLCVLMGKRCAREAAEAAERYLRTTLATYLRDETCRPRPGRVPRRGPPKGRRSRAGR
>NZ_CP053109.1|WP_171108849.1|9207399_9207912_+|pep-a2
MKTAVPCYYHLDVEVSPERVGQVSRILAAHLKYWDLETLVTPVCRSAELLLKAIDEHATDKHTSIEMWWNGQHLITAVGDNDQDLRPDQDLRACLEHIAAVSDGWGCCATDTGSKVIWFSQRARAGQRVPLVPKAPAPSLREGLQVPREIPVAALATPPRPADGALEDAR
>NZ_CP053109.1|WP_171108847.1|9207908_9210092_+|glycogen-debranching-protein-GlgX
MTKQPNRKDGVPAWSGHPYPLGAAYDGKGTNFALFSEVAERVELVLVDDGGRHRDVPLTEVDGFVWHGYLPDVGPGQRYGYRVHGPWHPAAGQRCNPAKLLLDPYATAVDGQIDNHPSLYERSASGPDPADSAGHTMLGVVTDPAFDWGHDRPIRRPYADTVIYEAHVRGLSRTHPDVPPELRGTYAGLAHPAIVDHLTSLGVTAVELMPVHQFVQDGVLQDRGLSNYWGYNTIGFFAPHNAYAAHGTRGRQVAEFKSMVKALHAAGLEVILDVVYNHTAEGNEKGPTLSFRGIDNSSYYRLVDGDFRHYYDTTGTGNSLLMRHPYVLQLIMDSLRYWVTEMHVDGFRFDLAATLARQFHEVDRLSAFFDLIQQDPVISRVKLIAEPWDVGEGGYQVGNFPPLWSEWNGKYRDAVRDFWRGEEHTLGEFASRLTGSSDLYQHSRRRPRASVNFVTAHDGFTLRDLVSYNDKHNEANGEGNRDGESDNRSWNCGAEGDSDDPAVLDLRARQQRNFLATLLLSQGIPMLCHGDEIGRTQGGNNNAYCQDNEVSWIDWRLTEEQRDLRDFARYVIALRAAHPVLRRRRFFRGETVTHAGQPLPDLVWLQPDATEMSDEDWQRSDAHSVGVFLNGDAIAEPDAYGRRVTDDSFLLLLNSYWEPVDFRLPDRTYGERWTTLIDTADPQGPPDETEHKAGTGLTVEARSLVLLSRPSRNQPPARKRGWARERR
>NZ_CP053109.1|WP_171108845.1|9210116_9210917_-|VOC-family-protein
MQHDTTPTTRTTDVVSTHTAFGAPCWVSLTSRDLRATEEFYTAVLGWEWRKAKLGDHFRIALANGAPVAGIAAVAAMWHMAVAWTPYFAVRSADEAVGRAQERGGTAAVGPIALPPGRAALLADRDGATFGIWEGELVTDWETWRRASPAFIRLHTRDAFDAAIFYGEVLEWAASRGCCEVNYEGEEVVLRSGGDVVARIESGALGAAPDPTIRPHWQIHFAVGDVAACARAAEHHGGSVLRLDADEAVLRDPDGAQFTVTARRQR
>NZ_CP053109.1|WP_171111455.1|9210984_9211374_+|ANTAR-domain-containing-protein
MPPAEYPGGTRQSRWEDVRVARVPHEPAGDTDRLRALEDEVAQLKEAMTSHAVVDQAIGMVVALGRVTPDQGWAVLKEVSQHTNIKLRTIAELILIWGRDGEMPPEIRAELEDALDRYGPTQIPGAPVE

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP053109_12	12.2\|6623404\|19\|NZ_CP053109\|CRISPRCasFinder	6623404-6623422	19	NZ_CP053109.1	7642283-7642301	2	0.895
NZ_CP053109_12	12.2\|6623404\|19\|NZ_CP053109\|CRISPRCasFinder	6623404-6623422	19	NZ_CP053109.1	7952240-7952258	2	0.895

1. spacer 12.2|6623404|19|NZ_CP053109|CRISPRCasFinder matches to position: 7642283-7642301, mismatch: 2, identity: 0.895

gctagccgagggctacgcc	CRISPR spacer
gctcgccgagggcgacgcc	Protospacer
*** ********* *****

2. spacer 12.2|6623404|19|NZ_CP053109|CRISPRCasFinder matches to position: 7952240-7952258, mismatch: 2, identity: 0.895

gctagccgagggctacgcc	CRISPR spacer
gctcgccgaggcctacgcc	Protospacer
*** ******* *******

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP053109_1	1.2\|1534137\|21\|NZ_CP053109\|CRT	1534137-1534157	21	NZ_CP015744	Shinella sp. HZN7 plasmid pShin-08, complete sequence	27839-27859	1	0.952
NZ_CP053109_2	2.5\|2571302\|24\|NZ_CP053109\|CRT	2571302-2571325	24	KR080198	Mycobacterium phage Cambiare, complete genome	24802-24825	2	0.917
NZ_CP053109_2	2.5\|2571302\|24\|NZ_CP053109\|CRT	2571302-2571325	24	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	567440-567463	3	0.875
NZ_CP053109_2	2.5\|2571302\|24\|NZ_CP053109\|CRT	2571302-2571325	24	NZ_CP016354	Prauserella marina strain DSM 45268 plasmid pPmarDSM45268, complete sequence	85019-85042	3	0.875
NZ_CP053109_4	4.3\|3479391\|27\|NZ_CP053109\|CRISPRCasFinder	3479391-3479417	27	NZ_CP050953	Rhodococcus sp. DMU1 plasmid unnamed	625707-625733	5	0.815
NZ_CP053109_4	4.3\|3479391\|27\|NZ_CP053109\|CRISPRCasFinder	3479391-3479417	27	NC_023286	Streptomyces sp. F12 plasmid pFRL6, complete sequence	173604-173630	5	0.815
NZ_CP053109_4	4.3\|3479391\|27\|NZ_CP053109\|CRISPRCasFinder	3479391-3479417	27	NC_023286	Streptomyces sp. F12 plasmid pFRL6, complete sequence	159036-159062	5	0.815
NZ_CP053109_4	4.3\|3479391\|27\|NZ_CP053109\|CRISPRCasFinder	3479391-3479417	27	NC_023283	Streptomyces sp. FR1 plasmid pFRL3, complete sequence	240787-240813	5	0.815
NZ_CP053109_4	4.3\|3479391\|27\|NZ_CP053109\|CRISPRCasFinder	3479391-3479417	27	NC_023284	Streptomyces sp. F2 plasmid pFRL4, complete sequence	314673-314699	5	0.815
NZ_CP053109_9	9.1\|6103276\|39\|NZ_CP053109\|CRISPRCasFinder	6103276-6103314	39	KT809302	Haloarcula californiae icosahedral virus 1, complete genome	11044-11082	6	0.846
NZ_CP053109_11	11.4\|6588443\|30\|NZ_CP053109\|CRISPRCasFinder	6588443-6588472	30	NC_047851	Brevibacterium phage LuckyBarnes, complete genome	10761-10790	6	0.8
NZ_CP053109_11	11.5\|6588497\|30\|NZ_CP053109\|CRISPRCasFinder	6588497-6588526	30	MN204503	Arthrobacter phage Linus, complete genome	51641-51670	6	0.8
NZ_CP053109_12	12.1\|6623353\|28\|NZ_CP053109\|CRISPRCasFinder	6623353-6623380	28	NZ_CP038636	Cupriavidus oxalaticus strain X32 plasmid unnamed1, complete sequence	1032255-1032282	6	0.786
NZ_CP053109_12	12.1\|6623353\|28\|NZ_CP053109\|CRISPRCasFinder	6623353-6623380	28	NC_042031	Mycobacterium phage Anaya, complete sequence	43357-43384	6	0.786
NZ_CP053109_15	15.1\|9198077\|28\|NZ_CP053109\|CRISPRCasFinder	9198077-9198104	28	NZ_AP017656	Sphingobium cloacae strain JCM 10874 plasmid pSCLO_2, complete sequence	80416-80443	6	0.786
NZ_CP053109_15	15.1\|9198077\|28\|NZ_CP053109\|CRISPRCasFinder	9198077-9198104	28	NZ_CP018821	Sphingomonas koreensis strain ABOJV plasmid tig00000001, complete sequence	175715-175742	6	0.786
NZ_CP053109_15	15.1\|9198077\|28\|NZ_CP053109\|CRISPRCasFinder	9198077-9198104	28	NZ_CP018821	Sphingomonas koreensis strain ABOJV plasmid tig00000001, complete sequence	253964-253991	6	0.786
NZ_CP053109_15	15.1\|9198077\|28\|NZ_CP053109\|CRISPRCasFinder	9198077-9198104	28	NZ_CP018821	Sphingomonas koreensis strain ABOJV plasmid tig00000001, complete sequence	273439-273466	6	0.786
NZ_CP053109_15	15.1\|9198077\|28\|NZ_CP053109\|CRISPRCasFinder	9198077-9198104	28	NZ_CP029986	Sphingomonas sp. FARSPH plasmid p01, complete sequence	7081-7108	6	0.786
NZ_CP053109_15	15.1\|9198077\|28\|NZ_CP053109\|CRISPRCasFinder	9198077-9198104	28	NZ_CP029986	Sphingomonas sp. FARSPH plasmid p01, complete sequence	262962-262989	6	0.786
NZ_CP053109_15	15.1\|9198077\|28\|NZ_CP053109\|CRISPRCasFinder	9198077-9198104	28	NZ_AP014706	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_2p, complete sequence	137054-137081	6	0.786
NZ_CP053109_15	15.1\|9198077\|28\|NZ_CP053109\|CRISPRCasFinder	9198077-9198104	28	NZ_CP013265	Sphingobium baderi strain DE-13 plasmid pDE1, complete sequence	143318-143345	6	0.786
NZ_CP053109_15	15.1\|9198077\|28\|NZ_CP053109\|CRISPRCasFinder	9198077-9198104	28	NZ_CP009453	Sphingopyxis sp. 113P3 plasmid unnamed, complete sequence	86008-86035	6	0.786
NZ_CP053109_15	15.1\|9198077\|28\|NZ_CP053109\|CRISPRCasFinder	9198077-9198104	28	NZ_CP054616	Azospirillum oryzae strain KACC 14407 plasmid unnamed2, complete sequence	378835-378862	6	0.786
NZ_CP053109_15	15.1\|9198077\|28\|NZ_CP053109\|CRISPRCasFinder	9198077-9198104	28	NC_008247	Sphingobium yanoikuyae plasmid pYAN-2 DNA, complete sequence	240-267	6	0.786
NZ_CP053109_15	15.1\|9198077\|28\|NZ_CP053109\|CRISPRCasFinder	9198077-9198104	28	NZ_CP025188	Roseomonas mucosa strain AD2 plasmid p1-AD2, complete sequence	119646-119673	6	0.786
NZ_CP053109_15	15.1\|9198077\|28\|NZ_CP053109\|CRISPRCasFinder	9198077-9198104	28	NZ_CP025188	Roseomonas mucosa strain AD2 plasmid p1-AD2, complete sequence	141011-141038	6	0.786
NZ_CP053109_15	15.1\|9198077\|28\|NZ_CP053109\|CRISPRCasFinder	9198077-9198104	28	NZ_CP025188	Roseomonas mucosa strain AD2 plasmid p1-AD2, complete sequence	282998-283025	6	0.786
NZ_CP053109_15	15.1\|9198077\|28\|NZ_CP053109\|CRISPRCasFinder	9198077-9198104	28	NZ_CP025188	Roseomonas mucosa strain AD2 plasmid p1-AD2, complete sequence	354563-354590	6	0.786
NZ_CP053109_15	15.1\|9198077\|28\|NZ_CP053109\|CRISPRCasFinder	9198077-9198104	28	NZ_CP025188	Roseomonas mucosa strain AD2 plasmid p1-AD2, complete sequence	355817-355844	6	0.786
NZ_CP053109_11	11.5\|6588497\|30\|NZ_CP053109\|CRISPRCasFinder	6588497-6588526	30	NZ_CP035709	Sphaerotilus natans subsp. sulfidivorans strain D-507 plasmid pSna507_unt12, complete sequence	22149-22178	7	0.767
NZ_CP053109_2	2.3\|2571218\|30\|NZ_CP053109\|CRT	2571218-2571247	30	NC_012586	Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence	757819-757848	8	0.733
NZ_CP053109_2	2.3\|2571218\|30\|NZ_CP053109\|CRT	2571218-2571247	30	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	3312915-3312944	8	0.733
NZ_CP053109_7	7.1\|5569073\|34\|NZ_CP053109\|CRISPRCasFinder	5569073-5569106	34	NC_021347	Rhodococcus phage E3, complete genome	103621-103654	8	0.765
NZ_CP053109_10	10.1\|6176420\|30\|NZ_CP053109\|CRISPRCasFinder	6176420-6176449	30	NZ_CP049734	Rhizobium leguminosarum strain A1 plasmid unnamed1, complete sequence	57795-57824	8	0.733
NZ_CP053109_10	10.1\|6176420\|30\|NZ_CP053109\|CRISPRCasFinder	6176420-6176449	30	CP049734	Rhizobium leguminosarum strain A1 plasmid pRLa11, complete sequence	175034-175063	8	0.733
NZ_CP053109_10	10.1\|6176420\|30\|NZ_CP053109\|CRISPRCasFinder	6176420-6176449	30	NZ_CP054035	Rhizobium sp. JKLM13E plasmid pPR13E04, complete sequence	25821-25850	8	0.733
NZ_CP053109_10	10.1\|6176420\|30\|NZ_CP053109\|CRISPRCasFinder	6176420-6176449	30	NZ_CP054024	Rhizobium sp. JKLM12A2 plasmid pPR12A203, complete sequence	151200-151229	8	0.733
NZ_CP053109_11	11.1\|6588269\|36\|NZ_CP053109\|CRISPRCasFinder	6588269-6588304	36	NZ_CP015203	Rhodococcus sp. 008 plasmid pR8L1, complete sequence	484485-484520	8	0.778
NZ_CP053109_11	11.5\|6588497\|30\|NZ_CP053109\|CRISPRCasFinder	6588497-6588526	30	NZ_CP032695	Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence	1814919-1814948	8	0.733
NZ_CP053109_11	11.5\|6588497\|30\|NZ_CP053109\|CRISPRCasFinder	6588497-6588526	30	MH155873	Microbacterium phage Paschalis, complete genome	43381-43410	9	0.7
NZ_CP053109_11	11.5\|6588497\|30\|NZ_CP053109\|CRISPRCasFinder	6588497-6588526	30	MH590600	Microbacterium phage KaiHaiDragon, complete genome	43282-43311	9	0.7
NZ_CP053109_11	11.5\|6588497\|30\|NZ_CP053109\|CRISPRCasFinder	6588497-6588526	30	MK977698	Microbacterium phage Busephilis, complete genome	43297-43326	9	0.7
NZ_CP053109_11	11.5\|6588497\|30\|NZ_CP053109\|CRISPRCasFinder	6588497-6588526	30	MT818415	Microbacterium phage Scumberland, complete genome	43599-43628	9	0.7
NZ_CP053109_11	11.5\|6588497\|30\|NZ_CP053109\|CRISPRCasFinder	6588497-6588526	30	NC_047993	Microbacterium phage Quhwah, complete genome	43974-44003	9	0.7
NZ_CP053109_11	11.5\|6588497\|30\|NZ_CP053109\|CRISPRCasFinder	6588497-6588526	30	MN062719	Microbacterium phage PiperSansNom, complete genome	43666-43695	9	0.7
NZ_CP053109_11	11.5\|6588497\|30\|NZ_CP053109\|CRISPRCasFinder	6588497-6588526	30	MN444877	Microbacterium phage Antares, complete genome	43590-43619	9	0.7
NZ_CP053109_11	11.5\|6588497\|30\|NZ_CP053109\|CRISPRCasFinder	6588497-6588526	30	NZ_CP039231	Piscirickettsia salmonis strain SR1 plasmid unnamed4, complete sequence	24781-24810	10	0.667
NZ_CP053109_11	11.5\|6588497\|30\|NZ_CP053109\|CRISPRCasFinder	6588497-6588526	30	NZ_CP039237	Piscirickettsia salmonis strain BI1 plasmid unnamed3, complete sequence	33151-33180	10	0.667
NZ_CP053109_11	11.5\|6588497\|30\|NZ_CP053109\|CRISPRCasFinder	6588497-6588526	30	NZ_CP039244	Piscirickettsia salmonis strain MR5 plasmid unnamed4, complete sequence	24782-24811	10	0.667
NZ_CP053109_11	11.5\|6588497\|30\|NZ_CP053109\|CRISPRCasFinder	6588497-6588526	30	NZ_CP039220	Piscirickettsia salmonis strain NVI 5692 plasmid unnamed1, complete sequence	57025-57054	10	0.667
NZ_CP053109_11	11.5\|6588497\|30\|NZ_CP053109\|CRISPRCasFinder	6588497-6588526	30	NZ_CP039233	Piscirickettsia salmonis strain SR1 plasmid unnamed6, complete sequence	34065-34094	10	0.667
NZ_CP053109_7	7.1\|5569073\|34\|NZ_CP053109\|CRISPRCasFinder	5569073-5569106	34	NZ_CP031166	Euzebya sp. DY32-46 plasmid pEDY32-46I, complete sequence	514943-514976	11	0.676
NZ_CP053109_7	7.1\|5569073\|34\|NZ_CP053109\|CRISPRCasFinder	5569073-5569106	34	NZ_CP032156	Mycobacterium sp. ELW1 plasmid pELW1-1, complete sequence	187485-187518	11	0.676

1. spacer 1.2|1534137|21|NZ_CP053109|CRT matches to NZ_CP015744 (Shinella sp. HZN7 plasmid pShin-08, complete sequence) position: , mismatch: 1, identity: 0.952

gggcctgagggctttcagctg	CRISPR spacer
gggcctgagcgctttcagctg	Protospacer
********* ***********

2. spacer 2.5|2571302|24|NZ_CP053109|CRT matches to KR080198 (Mycobacterium phage Cambiare, complete genome) position: , mismatch: 2, identity: 0.917

tggcggcggtgggggtgcgaacaa	CRISPR spacer
tggcggcggtggcggggcgaacaa	Protospacer
************ ** ********

3. spacer 2.5|2571302|24|NZ_CP053109|CRT matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 3, identity: 0.875

tggcggcggtgggggtgcgaacaa	CRISPR spacer
tggcggcggtgggggcgggaacac	Protospacer
***************.* *****

4. spacer 2.5|2571302|24|NZ_CP053109|CRT matches to NZ_CP016354 (Prauserella marina strain DSM 45268 plasmid pPmarDSM45268, complete sequence) position: , mismatch: 3, identity: 0.875

tggcggcggtgggggtgcgaacaa	CRISPR spacer
tggcggcggtgggggtgcgcagca	Protospacer
******************* *  *

5. spacer 4.3|3479391|27|NZ_CP053109|CRISPRCasFinder matches to NZ_CP050953 (Rhodococcus sp. DMU1 plasmid unnamed) position: , mismatch: 5, identity: 0.815

gtcccgaccacgggcggcaccacagcg	CRISPR spacer
gtcccgaccacgggcggcaccgtcggc	Protospacer
*********************.. *

6. spacer 4.3|3479391|27|NZ_CP053109|CRISPRCasFinder matches to NC_023286 (Streptomyces sp. F12 plasmid pFRL6, complete sequence) position: , mismatch: 5, identity: 0.815

gtcccgaccacgggcggcaccacagcg	CRISPR spacer
gcaccgtccacgggcggcaccacatcc	Protospacer
*. *** ***************** *

7. spacer 4.3|3479391|27|NZ_CP053109|CRISPRCasFinder matches to NC_023286 (Streptomyces sp. F12 plasmid pFRL6, complete sequence) position: , mismatch: 5, identity: 0.815

gtcccgaccacgggcggcaccacagcg	CRISPR spacer
gccccgaccaccggaggcaccacaggc	Protospacer
*.********* ** **********

8. spacer 4.3|3479391|27|NZ_CP053109|CRISPRCasFinder matches to NC_023283 (Streptomyces sp. FR1 plasmid pFRL3, complete sequence) position: , mismatch: 5, identity: 0.815

gtcccgaccacgggcggcaccacagcg	CRISPR spacer
gcaccgtccacgggcggcaccacatcc	Protospacer
*. *** ***************** *

9. spacer 4.3|3479391|27|NZ_CP053109|CRISPRCasFinder matches to NC_023284 (Streptomyces sp. F2 plasmid pFRL4, complete sequence) position: , mismatch: 5, identity: 0.815

gtcccgaccacgggcggcaccacagcg	CRISPR spacer
gcaccgtccacgggcggcaccacatcc	Protospacer
*. *** ***************** *

10. spacer 9.1|6103276|39|NZ_CP053109|CRISPRCasFinder matches to KT809302 (Haloarcula californiae icosahedral virus 1, complete genome) position: , mismatch: 6, identity: 0.846

acggtgacgacggcggctacggtgacgac-tcgtccacac	CRISPR spacer
acggtgacgacggcggcgacggtgacgacggcgacgacg-	Protospacer
***************** ***********  ** * **.

11. spacer 11.4|6588443|30|NZ_CP053109|CRISPRCasFinder matches to NC_047851 (Brevibacterium phage LuckyBarnes, complete genome) position: , mismatch: 6, identity: 0.8

gcgcaggtcaagcggtccggtggcggcatc	CRISPR spacer
gcgcagctcaagcggtccggtggtctggtc	Protospacer
****** ****************.   .**

12. spacer 11.5|6588497|30|NZ_CP053109|CRISPRCasFinder matches to MN204503 (Arthrobacter phage Linus, complete genome) position: , mismatch: 6, identity: 0.8

gtggacgttcacggcgccggtggtgttgtt	CRISPR spacer
gtggaggttcacggcgcccgtggcgacgct	Protospacer
***** ************ ****.* .*.*

13. spacer 12.1|6623353|28|NZ_CP053109|CRISPRCasFinder matches to NZ_CP038636 (Cupriavidus oxalaticus strain X32 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.786

agcggcagccatcgcacgccaggccgct	CRISPR spacer
ccaggcggccatcgcacgccaggccgtc	Protospacer
   ***.*******************..

14. spacer 12.1|6623353|28|NZ_CP053109|CRISPRCasFinder matches to NC_042031 (Mycobacterium phage Anaya, complete sequence) position: , mismatch: 6, identity: 0.786

agcggcagccatcgcacgccaggccgct	CRISPR spacer
cccggcagcaatcgcgcgccaggccgac	Protospacer
  ******* *****.********** .

15. spacer 15.1|9198077|28|NZ_CP053109|CRISPRCasFinder matches to NZ_AP017656 (Sphingobium cloacae strain JCM 10874 plasmid pSCLO_2, complete sequence) position: , mismatch: 6, identity: 0.786

caccgcggcgcccggtgtcacccccgat	CRISPR spacer
gtccgcggcgccccgtgtcatccccaaa	Protospacer
  *********** ******.****.*

16. spacer 15.1|9198077|28|NZ_CP053109|CRISPRCasFinder matches to NZ_CP018821 (Sphingomonas koreensis strain ABOJV plasmid tig00000001, complete sequence) position: , mismatch: 6, identity: 0.786

caccgcggcgcccggtgtcacccccgat	CRISPR spacer
gtccgcggcgccccgtgtcatccccaaa	Protospacer
  *********** ******.****.*

17. spacer 15.1|9198077|28|NZ_CP053109|CRISPRCasFinder matches to NZ_CP018821 (Sphingomonas koreensis strain ABOJV plasmid tig00000001, complete sequence) position: , mismatch: 6, identity: 0.786

caccgcggcgcccggtgtcacccccgat	CRISPR spacer
gtccgcggcgccccgtgtcatccccaaa	Protospacer
  *********** ******.****.*

18. spacer 15.1|9198077|28|NZ_CP053109|CRISPRCasFinder matches to NZ_CP018821 (Sphingomonas koreensis strain ABOJV plasmid tig00000001, complete sequence) position: , mismatch: 6, identity: 0.786

caccgcggcgcccggtgtcacccccgat	CRISPR spacer
gtccgcggcgccccgtgtcatccccaaa	Protospacer
  *********** ******.****.*

19. spacer 15.1|9198077|28|NZ_CP053109|CRISPRCasFinder matches to NZ_CP029986 (Sphingomonas sp. FARSPH plasmid p01, complete sequence) position: , mismatch: 6, identity: 0.786

caccgcggcgcccggtgtcacccccgat	CRISPR spacer
gtccgcggcgccccgtgtcatccccaaa	Protospacer
  *********** ******.****.*

20. spacer 15.1|9198077|28|NZ_CP053109|CRISPRCasFinder matches to NZ_CP029986 (Sphingomonas sp. FARSPH plasmid p01, complete sequence) position: , mismatch: 6, identity: 0.786

caccgcggcgcccggtgtcacccccgat	CRISPR spacer
gtccgcggcgccccgtgtcatccccaaa	Protospacer
  *********** ******.****.*

21. spacer 15.1|9198077|28|NZ_CP053109|CRISPRCasFinder matches to NZ_AP014706 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_2p, complete sequence) position: , mismatch: 6, identity: 0.786

caccgcggcgcccggtgtcacccccgat	CRISPR spacer
cgccgccgcgcgcggtgtcaccccctcg	Protospacer
*.**** **** *************

22. spacer 15.1|9198077|28|NZ_CP053109|CRISPRCasFinder matches to NZ_CP013265 (Sphingobium baderi strain DE-13 plasmid pDE1, complete sequence) position: , mismatch: 6, identity: 0.786

caccgcggcgcccggtgtcacccccgat	CRISPR spacer
gtccgcggcgccccgtgtcatccccaaa	Protospacer
  *********** ******.****.*

23. spacer 15.1|9198077|28|NZ_CP053109|CRISPRCasFinder matches to NZ_CP009453 (Sphingopyxis sp. 113P3 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.786

caccgcggcgcccggtgtcacccccgat	CRISPR spacer
gtccgcggcgccccgtgtcatccccaaa	Protospacer
  *********** ******.****.*

24. spacer 15.1|9198077|28|NZ_CP053109|CRISPRCasFinder matches to NZ_CP054616 (Azospirillum oryzae strain KACC 14407 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.786

caccgcggcgcccggtgtcacccccgat	CRISPR spacer
ggcggcggcgcccggtgacaccccccag	Protospacer
 .* ************* ******* *

25. spacer 15.1|9198077|28|NZ_CP053109|CRISPRCasFinder matches to NC_008247 (Sphingobium yanoikuyae plasmid pYAN-2 DNA, complete sequence) position: , mismatch: 6, identity: 0.786

caccgcggcgcccggtgtcacccccgat	CRISPR spacer
gtccgcggcgccccgtgtcatccccaaa	Protospacer
  *********** ******.****.*

26. spacer 15.1|9198077|28|NZ_CP053109|CRISPRCasFinder matches to NZ_CP025188 (Roseomonas mucosa strain AD2 plasmid p1-AD2, complete sequence) position: , mismatch: 6, identity: 0.786

caccgcggcgcccggtgtcacccccgat	CRISPR spacer
gtccgcggcgccccgtgtcatccccaaa	Protospacer
  *********** ******.****.*

27. spacer 15.1|9198077|28|NZ_CP053109|CRISPRCasFinder matches to NZ_CP025188 (Roseomonas mucosa strain AD2 plasmid p1-AD2, complete sequence) position: , mismatch: 6, identity: 0.786

caccgcggcgcccggtgtcacccccgat	CRISPR spacer
gtccgcggcgccccgtgtcatccccaaa	Protospacer
  *********** ******.****.*

28. spacer 15.1|9198077|28|NZ_CP053109|CRISPRCasFinder matches to NZ_CP025188 (Roseomonas mucosa strain AD2 plasmid p1-AD2, complete sequence) position: , mismatch: 6, identity: 0.786

caccgcggcgcccggtgtcacccccgat	CRISPR spacer
gtccgcggcgccccgtgtcatccccaaa	Protospacer
  *********** ******.****.*

29. spacer 15.1|9198077|28|NZ_CP053109|CRISPRCasFinder matches to NZ_CP025188 (Roseomonas mucosa strain AD2 plasmid p1-AD2, complete sequence) position: , mismatch: 6, identity: 0.786

caccgcggcgcccggtgtcacccccgat	CRISPR spacer
gtccgcggcgccccgtgtcatccccaaa	Protospacer
  *********** ******.****.*

30. spacer 15.1|9198077|28|NZ_CP053109|CRISPRCasFinder matches to NZ_CP025188 (Roseomonas mucosa strain AD2 plasmid p1-AD2, complete sequence) position: , mismatch: 6, identity: 0.786

caccgcggcgcccggtgtcacccccgat	CRISPR spacer
gtccgcggcgccccgtgtcatccccaaa	Protospacer
  *********** ******.****.*

31. spacer 11.5|6588497|30|NZ_CP053109|CRISPRCasFinder matches to NZ_CP035709 (Sphaerotilus natans subsp. sulfidivorans strain D-507 plasmid pSna507_unt12, complete sequence) position: , mismatch: 7, identity: 0.767

gtggacgttcacggcgccggtggtgttgtt	CRISPR spacer
gtgggcgtgcacggcgccggtggacatgcg	Protospacer
****.*** **************   **.

32. spacer 2.3|2571218|30|NZ_CP053109|CRT matches to NC_012586 (Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence) position: , mismatch: 8, identity: 0.733

taacaacgggggtggcggcgcgaacaacaa	CRISPR spacer
cggcaacgggggtggcggcgtgaccatgca	Protospacer
...*****************.** **   *

33. spacer 2.3|2571218|30|NZ_CP053109|CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 8, identity: 0.733

taacaacgggggtggcggcgcgaacaacaa	CRISPR spacer
aaggtgcggtggtggcggcgcgaacagcag	Protospacer
 *.  .*** ****************.**.

34. spacer 7.1|5569073|34|NZ_CP053109|CRISPRCasFinder matches to NC_021347 (Rhodococcus phage E3, complete genome) position: , mismatch: 8, identity: 0.765

ccgcag-ccgcctcaggggcagccgcagccggggc	CRISPR spacer
-tacggcccgccgcagggccagccgcagccgcagc	Protospacer
 ..*.* ***** ***** ************ .**

35. spacer 10.1|6176420|30|NZ_CP053109|CRISPRCasFinder matches to NZ_CP049734 (Rhizobium leguminosarum strain A1 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

gggacgggaaccaactgcctcgaagccgcc	CRISPR spacer
cgcttcggaaacacctgcctcgaagccgct	Protospacer
 *  . **** ** ***************.

36. spacer 10.1|6176420|30|NZ_CP053109|CRISPRCasFinder matches to CP049734 (Rhizobium leguminosarum strain A1 plasmid pRLa11, complete sequence) position: , mismatch: 8, identity: 0.733

gggacgggaaccaactgcctcgaagccgcc	CRISPR spacer
cgcttcggaaacacctgcctcgaagccgct	Protospacer
 *  . **** ** ***************.

37. spacer 10.1|6176420|30|NZ_CP053109|CRISPRCasFinder matches to NZ_CP054035 (Rhizobium sp. JKLM13E plasmid pPR13E04, complete sequence) position: , mismatch: 8, identity: 0.733

gggacgggaaccaactgcctcgaagccgcc	CRISPR spacer
cgcttcggaaacacctgcctcgaagccgct	Protospacer
 *  . **** ** ***************.

38. spacer 10.1|6176420|30|NZ_CP053109|CRISPRCasFinder matches to NZ_CP054024 (Rhizobium sp. JKLM12A2 plasmid pPR12A203, complete sequence) position: , mismatch: 8, identity: 0.733

gggacgggaaccaactgcctcgaagccgcc	CRISPR spacer
cgcttcggaaacacctgcctcgaagccgct	Protospacer
 *  . **** ** ***************.

39. spacer 11.1|6588269|36|NZ_CP053109|CRISPRCasFinder matches to NZ_CP015203 (Rhodococcus sp. 008 plasmid pR8L1, complete sequence) position: , mismatch: 8, identity: 0.778

gtcggtggacacgcggtaggtggcccggggcaccga	CRISPR spacer
gcagctggacacgcggtaggtggccggcggcactac	Protospacer
*. * ******************** * *****..

40. spacer 11.5|6588497|30|NZ_CP053109|CRISPRCasFinder matches to NZ_CP032695 (Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence) position: , mismatch: 8, identity: 0.733

gtggacgttcacggcgccggtggtgttgtt	CRISPR spacer
actgacggtcacggcgccggtgctgttcgg	Protospacer
.. **** ************** ****

41. spacer 11.5|6588497|30|NZ_CP053109|CRISPRCasFinder matches to MH155873 (Microbacterium phage Paschalis, complete genome) position: , mismatch: 9, identity: 0.7

gtggacgttcacggcgccggtggtgttgtt	CRISPR spacer
caggacgttcacggcgacggcggtgggcac	Protospacer
  ************** ***.****    .

42. spacer 11.5|6588497|30|NZ_CP053109|CRISPRCasFinder matches to MH590600 (Microbacterium phage KaiHaiDragon, complete genome) position: , mismatch: 9, identity: 0.7

gtggacgttcacggcgccggtggtgttgtt	CRISPR spacer
caggacgttcacggcgacggcggtgggcac	Protospacer
  ************** ***.****    .

43. spacer 11.5|6588497|30|NZ_CP053109|CRISPRCasFinder matches to MK977698 (Microbacterium phage Busephilis, complete genome) position: , mismatch: 9, identity: 0.7

gtggacgttcacggcgccggtggtgttgtt	CRISPR spacer
aaggacgttcacggcgacggcggtgggaac	Protospacer
. ************** ***.****  . .

44. spacer 11.5|6588497|30|NZ_CP053109|CRISPRCasFinder matches to MT818415 (Microbacterium phage Scumberland, complete genome) position: , mismatch: 9, identity: 0.7

gtggacgttcacggcgccggtggtgttgtt	CRISPR spacer
caggacgttcacggcgacggcggtgggcac	Protospacer
  ************** ***.****    .

45. spacer 11.5|6588497|30|NZ_CP053109|CRISPRCasFinder matches to NC_047993 (Microbacterium phage Quhwah, complete genome) position: , mismatch: 9, identity: 0.7

gtggacgttcacggcgccggtggtgttgtt	CRISPR spacer
caggacgttcacggcgacggcggtgggcac	Protospacer
  ************** ***.****    .

46. spacer 11.5|6588497|30|NZ_CP053109|CRISPRCasFinder matches to MN062719 (Microbacterium phage PiperSansNom, complete genome) position: , mismatch: 9, identity: 0.7

gtggacgttcacggcgccggtggtgttgtt	CRISPR spacer
aaggacgttcacggcgacggcggtgggcac	Protospacer
. ************** ***.****    .

47. spacer 11.5|6588497|30|NZ_CP053109|CRISPRCasFinder matches to MN444877 (Microbacterium phage Antares, complete genome) position: , mismatch: 9, identity: 0.7

gtggacgttcacggcgccggtggtgttgtt	CRISPR spacer
caggacgttcacggcgacggcggtgggcac	Protospacer
  ************** ***.****    .

48. spacer 11.5|6588497|30|NZ_CP053109|CRISPRCasFinder matches to NZ_CP039231 (Piscirickettsia salmonis strain SR1 plasmid unnamed4, complete sequence) position: , mismatch: 10, identity: 0.667

gtggacgttcacggcgccggtggtgttgtt	CRISPR spacer
aatcctattcacggcgccggtggtggtggc	Protospacer
.    ..****************** ** .

49. spacer 11.5|6588497|30|NZ_CP053109|CRISPRCasFinder matches to NZ_CP039237 (Piscirickettsia salmonis strain BI1 plasmid unnamed3, complete sequence) position: , mismatch: 10, identity: 0.667

gtggacgttcacggcgccggtggtgttgtt	CRISPR spacer
aatcctattcacggcgccggtggtggtggc	Protospacer
.    ..****************** ** .

50. spacer 11.5|6588497|30|NZ_CP053109|CRISPRCasFinder matches to NZ_CP039244 (Piscirickettsia salmonis strain MR5 plasmid unnamed4, complete sequence) position: , mismatch: 10, identity: 0.667

gtggacgttcacggcgccggtggtgttgtt	CRISPR spacer
aatcctattcacggcgccggtggtggtggc	Protospacer
.    ..****************** ** .

51. spacer 11.5|6588497|30|NZ_CP053109|CRISPRCasFinder matches to NZ_CP039220 (Piscirickettsia salmonis strain NVI 5692 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.667

gtggacgttcacggcgccggtggtgttgtt	CRISPR spacer
aaaatgattcacggcgccggtggtggtggc	Protospacer
. ..  .****************** ** .

52. spacer 11.5|6588497|30|NZ_CP053109|CRISPRCasFinder matches to NZ_CP039233 (Piscirickettsia salmonis strain SR1 plasmid unnamed6, complete sequence) position: , mismatch: 10, identity: 0.667

gtggacgttcacggcgccggtggtgttgtt	CRISPR spacer
aaaatgattcacggcgccggtggtggtggc	Protospacer
. ..  .****************** ** .

53. spacer 7.1|5569073|34|NZ_CP053109|CRISPRCasFinder matches to NZ_CP031166 (Euzebya sp. DY32-46 plasmid pEDY32-46I, complete sequence) position: , mismatch: 11, identity: 0.676

ccgcagccgcctcaggggcagccgcagccggggc	CRISPR spacer
ccgcagccgcctcagaggcatccgtcatcttcaa	Protospacer
***************.**** ***. ..*   .

54. spacer 7.1|5569073|34|NZ_CP053109|CRISPRCasFinder matches to NZ_CP032156 (Mycobacterium sp. ELW1 plasmid pELW1-1, complete sequence) position: , mismatch: 11, identity: 0.676

ccgcagccgcctcaggggcagccgcagccggggc	CRISPR spacer
ccgcagccgccgcaggggcggccgaggtgacatg	Protospacer
*********** *******.**** .*. . .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

25180 : 60516

Gordonia_phage(25.0%)

transposase,integrase

attL 31446:31462|attR 44406:44422

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_171116290.1\|25180_27265_+\|transposase	ISAzo13 family transposase	NA	NA	NA	NA
WP_171110551.1\|27988_28636_+	dihydrofolate reductase family protein	NA	NA	NA	NA
WP_171117725.1\|30050_30365_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
31446:31462	attL	NA	NA	NA	NA
WP_171117728.1\|31543_32962_-\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_171117730.1\|34030_34342_+\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	2.2e-17	53.3
WP_171117732.1\|34338_34752_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_171133957.1\|34846_35128_+\|transposase	transposase	NA	NA	NA	NA
WP_171133947.1\|35631_36027_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A0P0I4A4	Acinetobacter_phage	2.3e-14	41.8
WP_171118606.1\|36044_36536_-\|transposase	transposase	NA	NA	NA	NA
WP_171112835.1\|36539_37424_-\|transposase	transposase domain-containing protein	NA	NA	NA	NA
WP_171112837.1\|37633_38128_+\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	2.6e-44	56.5
WP_171112839.1\|38559_39291_+	hypothetical protein	NA	NA	NA	NA
WP_171112841.1\|39489_40188_-	response regulator transcription factor	NA	NA	NA	NA
WP_171112842.1\|41785_42463_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_171112844.1\|42560_43865_+	serine hydroxymethyltransferase	A0A219Y950	Aeromonas_phage	5.3e-92	49.7
WP_171112846.1\|43861_45082_+	sarcosine oxidase subunit beta family protein	NA	NA	NA	NA
44406:44422	attR	NA	NA	NA	NA
WP_171112848.1\|45092_45389_+	sarcosine oxidase subunit delta	NA	NA	NA	NA
WP_171112850.1\|45385_48250_+	sarcosine oxidase subunit alpha family protein	NA	NA	NA	NA
WP_171112852.1\|48242_48878_+	sarcosine oxidase subunit gamma family protein	NA	NA	NA	NA
WP_171112854.1\|49129_51454_-	family 43 glycosylhydrolase	NA	NA	NA	NA
WP_171112856.1\|51821_52901_-	Ldh family oxidoreductase	NA	NA	NA	NA
WP_171112858.1\|52921_54640_-	thiamine pyrophosphate-binding protein	NA	NA	NA	NA
WP_171112860.1\|54653_55514_-	amidohydrolase	NA	NA	NA	NA
WP_171112862.1\|55671_56889_-	L-2-hydroxyglutarate oxidase	NA	NA	NA	NA
WP_171112864.1\|56931_58380_-	aldehyde dehydrogenase	NA	NA	NA	NA
WP_171112866.1\|58611_58899_+	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_171133958.1\|59446_59989_+	winged helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_171133959.1\|59913_60516_+\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_2

868420 : 880096

Mycobacterium_phage(37.5%)

capsid,portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_171110631.1\|868420_868597_-	hypothetical protein	A0A2P1CJ82	Mycobacterium_phage	8.2e-09	54.9
WP_171110630.1\|868654_869296_-	hypothetical protein	NA	NA	NA	NA
WP_171110629.1\|869273_870254_-	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_171110628.1\|870250_870754_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_171110627.1\|870756_871008_-	hypothetical protein	NA	NA	NA	NA
WP_171107100.1\|871019_872540_-	hypothetical protein	A0A166Y926	Gordonia_phage	8.1e-36	49.7
WP_171110626.1\|872603_873575_-\|capsid	phage major capsid protein	I3NL99	Bifidobacterium_phage	2.8e-66	41.8
WP_171110625.1\|873652_874222_-	DUF4355 domain-containing protein	A0A088FQ73	Mycobacterium_phage	3.3e-14	43.2
WP_171110624.1\|874327_874642_-	hypothetical protein	NA	NA	NA	NA
WP_171110623.1\|874647_875361_-	hypothetical protein	A0A2I2MPD0	Mycobacterium_phage	4.7e-10	30.5
WP_171110622.1\|875365_876763_-\|portal	phage portal protein	A0A1C9LXM1	Streptomyces_phage	1.7e-72	37.2
WP_171110621.1\|876767_878483_-	Terminase	A0A1B3AY92	Gordonia_phage	4.0e-108	40.7
WP_171110620.1\|878472_878655_-	hypothetical protein	NA	NA	NA	NA
WP_171110619.1\|878668_879205_-	hypothetical protein	NA	NA	NA	NA
WP_171110618.1\|879244_879490_-	hypothetical protein	NA	NA	NA	NA
WP_171110617.1\|879502_880096_-	DNA primase	Q6VY59	Streptomyces_phage	1.1e-36	50.9

DBSCAN-SWA_3

1302167 : 1320385

Enterobacteria_phage(20.0%)

protease,integrase,transposase

attL 1319718:1319735|attR 1323090:1323107

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_171109377.1\|1302167_1304702_+\|protease	ATP-dependent Clp protease ATP-binding subunit	H6X3M6	Enterobacteria_phage	5.0e-131	41.1
WP_171133992.1\|1304731_1306534_-	gamma-glutamyltransferase	NA	NA	NA	NA
WP_171109376.1\|1306649_1307402_+	hypothetical protein	NA	NA	NA	NA
WP_171109375.1\|1307527_1309096_+	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_171109374.1\|1309224_1309632_-	hypothetical protein	NA	NA	NA	NA
WP_171109373.1\|1309813_1311574_+	SGNH/GDSL hydrolase family protein	NA	NA	NA	NA
WP_171109372.1\|1311605_1312385_-	exodeoxyribonuclease III	NA	NA	NA	NA
WP_171109371.1\|1312435_1313068_-	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_171109370.1\|1313102_1314401_-	4-carboxymuconolactone decarboxylase	A0A1C9LYC8	Mycobacterium_phage	5.5e-09	30.1
WP_171111513.1\|1314582_1315776_-\|integrase	site-specific integrase	A0A160DFA7	Gordonia_phage	3.2e-19	25.4
WP_171109369.1\|1317323_1317797_+	hypothetical protein	NA	NA	NA	NA
WP_171109368.1\|1317865_1318699_+\|transposase	transposase	NA	NA	NA	NA
WP_171133957.1\|1319203_1319485_+\|transposase	transposase	NA	NA	NA	NA
WP_171133993.1\|1319498_1320077_+\|transposase	IS3 family transposase	Q716C2	Shigella_phage	2.7e-08	28.6
1319718:1319735	attL	NA	NA	NA	NA
WP_171133994.1\|1320073_1320385_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A0P0I4A4	Acinetobacter_phage	5.2e-14	41.8
WP_171133994.1\|1320073_1320385_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A0P0I4A4	Acinetobacter_phage	5.2e-14	41.8
1323090:1323107	attR	NA	NA	NA	NA

DBSCAN-SWA_4

4321565 : 4356978

Saccharomonospora_phage(25.0%)

tail,transposase,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_171109587.1\|4321565_4322105_-\|transposase	transposase	NA	NA	NA	NA
WP_171109588.1\|4322451_4323513_+	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_171111573.1\|4323648_4325016_+	sugar ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_171109589.1\|4325023_4326028_+	sugar ABC transporter permease	NA	NA	NA	NA
WP_171109590.1\|4326024_4326903_+	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_171109591.1\|4326951_4328424_+	glycoside hydrolase family 32 protein	NA	NA	NA	NA
WP_171109592.1\|4328613_4330407_+	coagulation factor 5/8 type domain-containing protein	NA	NA	NA	NA
WP_171109593.1\|4330439_4330604_-	hypothetical protein	NA	NA	NA	NA
WP_171115766.1\|4333680_4334343_-	hypothetical protein	NA	NA	NA	NA
WP_171118937.1\|4335772_4336099_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_171115768.1\|4336455_4337097_+	NAD(P)H-dependent oxidoreductase	NA	NA	NA	NA
WP_171115770.1\|4337204_4337510_+	hypothetical protein	NA	NA	NA	NA
WP_171115772.1\|4337545_4337686_+	hypothetical protein	NA	NA	NA	NA
WP_171115774.1\|4338518_4339094_+	dCTP deaminase	I4AZP2	Saccharomonospora_phage	1.4e-76	70.9
WP_171115776.1\|4339127_4339625_+	phosphoribosyltransferase	NA	NA	NA	NA
WP_171115778.1\|4339766_4340768_-	YIP1 family protein	NA	NA	NA	NA
WP_171115780.1\|4340976_4341318_+	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_171118939.1\|4341511_4342231_+	flavodoxin family protein	NA	NA	NA	NA
WP_171134047.1\|4342305_4343055_-	zinc ribbon domain-containing protein	NA	NA	NA	NA
WP_171117318.1\|4344118_4344682_-\|tail	phage tail protein	NA	NA	NA	NA
WP_171117316.1\|4344783_4346745_-\|plate	putative baseplate assembly protein	NA	NA	NA	NA
WP_171117314.1\|4346744_4347167_-	GPW/gp25 family protein	A0A1D8KT65	Synechococcus_phage	5.8e-08	32.3
WP_171117312.1\|4347449_4347791_-	PAAR domain-containing protein	NA	NA	NA	NA
WP_171117310.1\|4347825_4349649_-	VgrG-related protein	NA	NA	NA	NA
WP_171117308.1\|4349645_4350368_-	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_171117306.1\|4350420_4350846_-\|tail	phage tail protein	A0A059XEM3	uncultured_phage	6.0e-05	28.3
WP_171117305.1\|4350875_4354259_-	hypothetical protein	NA	NA	NA	NA
WP_171117303.1\|4354263_4354422_-	hypothetical protein	NA	NA	NA	NA
WP_171117302.1\|4354418_4354913_-	hypothetical protein	NA	NA	NA	NA
WP_171117300.1\|4354909_4355350_-\|tail	phage tail protein	NA	NA	NA	NA
WP_171117298.1\|4355409_4356978_-\|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	3.7e-68	34.1

DBSCAN-SWA_5

6741488 : 6789059

uncultured_virus(12.5%)

transposase,integrase

attL 6754011:6754031|attR 6786161:6786181

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_171111782.1\|6741488_6743123_-\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_171110553.1\|6743455_6743737_-	metal-sensitive transcriptional regulator	NA	NA	NA	NA
WP_171110554.1\|6743764_6746026_-	copper-translocating P-type ATPase	A0A218MNH6	uncultured_virus	4.8e-85	35.6
WP_171110555.1\|6746106_6746382_-	heavy-metal-associated domain-containing protein	NA	NA	NA	NA
WP_171110556.1\|6746556_6747522_+	hypothetical protein	NA	NA	NA	NA
WP_171111784.1\|6748389_6748728_+	hypothetical protein	NA	NA	NA	NA
WP_171110557.1\|6748869_6750012_+	PLP-dependent cysteine synthase family protein	A0A1W6JHY1	Lactococcus_phage	3.1e-32	30.4
WP_171110558.1\|6750008_6751310_+	MFS transporter	NA	NA	NA	NA
WP_171110559.1\|6751392_6752613_+	DUF1015 domain-containing protein	NA	NA	NA	NA
6754011:6754031	attL	NA	NA	NA	NA
WP_171110560.1\|6754919_6755711_+	ATP-binding protein	U5N3V8	Enterobacteria_phage	1.8e-26	32.2
WP_171110561.1\|6755735_6756407_-	DUF3784 domain-containing protein	NA	NA	NA	NA
WP_171110562.1\|6756493_6756865_-	hypothetical protein	NA	NA	NA	NA
WP_171134092.1\|6757237_6758164_-	hypothetical protein	NA	NA	NA	NA
WP_171110564.1\|6758379_6758820_-	hypothetical protein	NA	NA	NA	NA
WP_171110565.1\|6759230_6761129_+	copper resistance protein CopC/CopD	NA	NA	NA	NA
WP_171110566.1\|6761301_6761940_+	DUF3105 domain-containing protein	NA	NA	NA	NA
WP_171110567.1\|6762025_6762619_-	histidine phosphatase family protein	NA	NA	NA	NA
WP_171110568.1\|6762885_6763107_+	CbtB-domain containing protein	NA	NA	NA	NA
WP_171110569.1\|6763123_6763888_+	CbtA family protein	NA	NA	NA	NA
WP_171110570.1\|6764182_6764401_-	heavy-metal-associated domain-containing protein	NA	NA	NA	NA
WP_171111786.1\|6764568_6764901_+	NADH-quinone oxidoreductase subunit A	NA	NA	NA	NA
WP_171110571.1\|6764891_6766325_+	hypothetical protein	NA	NA	NA	NA
WP_171110572.1\|6766317_6767259_+	NADH-quinone oxidoreductase subunit H	NA	NA	NA	NA
WP_171110573.1\|6767266_6767836_+	NADH-quinone oxidoreductase subunit J	NA	NA	NA	NA
WP_171110574.1\|6767832_6768138_+	NADH-quinone oxidoreductase subunit NuoK	NA	NA	NA	NA
WP_171110575.1\|6768134_6769985_+	NADH-quinone oxidoreductase subunit L	NA	NA	NA	NA
WP_171111788.1\|6769990_6771499_+	NADH-quinone oxidoreductase subunit M	NA	NA	NA	NA
WP_171111790.1\|6771504_6772926_+	NADH-quinone oxidoreductase subunit N	NA	NA	NA	NA
WP_171133996.1\|6773379_6774198_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_171111883.1\|6774262_6775291_-	C40 family peptidase	A0A222YZ81	Streptomyces_phage	9.4e-12	37.2
WP_171111881.1\|6775437_6776352_-	M56 family metallopeptidase	NA	NA	NA	NA
WP_171111879.1\|6776348_6776717_-	BlaI/MecI/CopY family transcriptional regulator	NA	NA	NA	NA
WP_171111869.1\|6777023_6777194_-	hypothetical protein	NA	NA	NA	NA
WP_171111877.1\|6777376_6777697_+	hypothetical protein	NA	NA	NA	NA
WP_171111875.1\|6777896_6779273_+	hypothetical protein	NA	NA	NA	NA
WP_171111873.1\|6779269_6779836_+	hypothetical protein	NA	NA	NA	NA
WP_171111871.1\|6779832_6781764_+	hypothetical protein	NA	NA	NA	NA
WP_171133994.1\|6782084_6782396_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A0P0I4A4	Acinetobacter_phage	5.2e-14	41.8
WP_171133993.1\|6782392_6782971_-\|transposase	IS3 family transposase	Q716C2	Shigella_phage	2.7e-08	28.6
WP_171134068.1\|6782967_6783267_-\|transposase	transposase	A9YX41	Burkholderia_phage	4.2e-05	36.2
WP_171111164.1\|6783336_6783492_+	hypothetical protein	NA	NA	NA	NA
WP_171111166.1\|6783615_6783912_-	hypothetical protein	NA	NA	NA	NA
WP_171111167.1\|6783908_6784352_-	hypothetical protein	NA	NA	NA	NA
WP_171111169.1\|6784348_6785062_-	ParA family protein	NA	NA	NA	NA
WP_171111172.1\|6785251_6785839_-	helix-turn-helix domain containing protein	NA	NA	NA	NA
WP_171111174.1\|6785820_6787140_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
6786161:6786181	attR	NA	NA	NA	NA
WP_171111855.1\|6787808_6789059_+\|transposase	IS21 family transposase	A0A2L1IVA1	Escherichia_phage	6.7e-28	35.2

DBSCAN-SWA_6

7599206 : 7668930

Bacillus_phage(14.29%)

tail,protease,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_171113324.1\|7599206_7601075_+\|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	1.6e-46	36.4
WP_141309194.1\|7601115_7601640_+\|tail	phage tail protein	NA	NA	NA	NA
WP_171113326.1\|7601662_7602385_+	hypothetical protein	NA	NA	NA	NA
WP_171134102.1\|7602377_7603139_+	hypothetical protein	NA	NA	NA	NA
WP_171113328.1\|7603203_7604031_+	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_171118649.1\|7604064_7606068_+	AAA family ATPase	A0A109WUE1	Acidianus_tailed_spindle_virus	1.9e-08	34.8
WP_171113330.1\|7606058_7606331_+	hypothetical protein	NA	NA	NA	NA
WP_171113334.1\|7612950_7614174_+	hypothetical protein	NA	NA	NA	NA
WP_171113335.1\|7614194_7614878_+	hypothetical protein	NA	NA	NA	NA
WP_171113337.1\|7614886_7615264_+	hypothetical protein	NA	NA	NA	NA
WP_171113339.1\|7615256_7616396_+	hypothetical protein	NA	NA	NA	NA
WP_171113341.1\|7616418_7616955_+\|plate	baseplate assembly protein	NA	NA	NA	NA
WP_171113343.1\|7616978_7617323_+	hypothetical protein	NA	NA	NA	NA
WP_171113345.1\|7617309_7617489_-	hypothetical protein	NA	NA	NA	NA
WP_171134152.1\|7617596_7618013_+	GPW/gp25 family protein	NA	NA	NA	NA
WP_171134103.1\|7618009_7621102_+\|plate	putative baseplate assembly protein	A0A1Q1PVP2	Phage_DP-2017a	6.3e-11	23.8
WP_171113347.1\|7621098_7624839_+\|plate	putative baseplate assembly protein	NA	NA	NA	NA
WP_171113349.1\|7624838_7626992_+	hypothetical protein	NA	NA	NA	NA
WP_171113351.1\|7627077_7628607_+	hypothetical protein	NA	NA	NA	NA
WP_171113353.1\|7628606_7629503_+	N-acetylmuramoyl-L-alanine amidase	A0A142K646	Streptomyces_phage	1.7e-94	60.2
WP_171113355.1\|7629610_7630630_-	aldo/keto reductase	NA	NA	NA	NA
WP_171113357.1\|7630747_7631338_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_171118654.1\|7631349_7632720_-	M1 family metallopeptidase	A0A0P0IY26	Acinetobacter_phage	1.6e-14	23.4
WP_171113359.1\|7632779_7636646_-	amino acid adenylation domain-containing protein	A0A2K9KZV5	Tupanvirus	3.4e-38	25.8
WP_171113361.1\|7637169_7638495_+	M20/M25/M40 family metallo-hydrolase	NA	NA	NA	NA
WP_141309216.1\|7638652_7638886_+	DUF320 domain-containing protein	NA	NA	NA	NA
WP_171113363.1\|7638997_7639816_+	DUF320 domain-containing protein	NA	NA	NA	NA
WP_171113365.1\|7639906_7640095_-	hypothetical protein	NA	NA	NA	NA
WP_171113366.1\|7640142_7640862_+	hypothetical protein	NA	NA	NA	NA
WP_171113368.1\|7640935_7643155_-	ATP-binding domain-containing protein	NA	NA	NA	NA
WP_171113370.1\|7643151_7644138_-	aldo/keto reductase	NA	NA	NA	NA
WP_171113372.1\|7644263_7645319_+	LLM class F420-dependent oxidoreductase	NA	NA	NA	NA
WP_171113374.1\|7645546_7646335_+	ferritin-like domain-containing protein	NA	NA	NA	NA
WP_171113376.1\|7646466_7647153_+	MSMEG_4193 family putative phosphomutase	NA	NA	NA	NA
WP_171113378.1\|7647274_7647865_+	DUF3090 domain-containing protein	NA	NA	NA	NA
WP_171113380.1\|7647828_7648647_+	SCO1664 family protein	NA	NA	NA	NA
WP_171113382.1\|7648780_7650010_+	cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase	NA	NA	NA	NA
WP_171113384.1\|7650065_7651040_-	PAC2 family protein	NA	NA	NA	NA
WP_171113385.1\|7651358_7652975_-	glycerol-3-phosphate dehydrogenase/oxidase	NA	NA	NA	NA
WP_171113387.1\|7653024_7654566_-	glycerol kinase GlpK	NA	NA	NA	NA
WP_171113389.1\|7654647_7655442_-	aquaporin family protein	M1HWZ0	Paramecium_bursaria_Chlorella_virus	1.9e-23	30.7
WP_171113391.1\|7655792_7656557_-	IclR family transcriptional regulator	NA	NA	NA	NA
WP_171113393.1\|7656904_7660417_+	methionine synthase	NA	NA	NA	NA
WP_171113395.1\|7660546_7661239_+	HAD family phosphatase	NA	NA	NA	NA
WP_171113396.1\|7661668_7663270_+	peptide-binding protein	NA	NA	NA	NA
WP_171113398.1\|7663341_7664922_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_141309237.1\|7665000_7665672_-	response regulator	NA	NA	NA	NA
WP_171113400.1\|7665908_7666967_-	RecB family exonuclease	NA	NA	NA	NA
WP_171113401.1\|7667142_7668930_+\|protease	site-2 protease family protein	NA	NA	NA	NA

DBSCAN-SWA_7

7900400 : 7911765

Gordonia_phage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_171117891.1\|7900400_7901237_+	phage antirepressor	A0A1L6BZH6	Pasteurella_phage	4.5e-44	37.9
WP_171117889.1\|7901233_7901479_+	hypothetical protein	NA	NA	NA	NA
WP_171117887.1\|7901475_7901730_+	hypothetical protein	NA	NA	NA	NA
WP_171117884.1\|7901726_7902464_+	hypothetical protein	A0A249XTW9	Mycobacterium_phage	8.3e-18	30.5
WP_171117882.1\|7902400_7902796_-	hypothetical protein	NA	NA	NA	NA
WP_171117880.1\|7902779_7903232_+	hypothetical protein	NA	NA	NA	NA
WP_171117878.1\|7903228_7903603_+	hypothetical protein	NA	NA	NA	NA
WP_171117876.1\|7903766_7904114_+	hypothetical protein	NA	NA	NA	NA
WP_171117875.1\|7904110_7904935_+	hypothetical protein	A0A0R8VB90	Thermobifida_phage	1.6e-54	42.7
WP_171117873.1\|7904946_7905714_+	AAA family ATPase	A0A160DER9	Gordonia_phage	7.7e-51	44.7
WP_171117871.1\|7905775_7906150_+	hypothetical protein	NA	NA	NA	NA
WP_171117869.1\|7906274_7907114_+	hypothetical protein	A0A2P1A0S7	Gordonia_phage	1.0e-11	30.7
WP_171117867.1\|7907113_7908832_+	DNA cytosine methyltransferase	A0A0K1LMQ3	Caulobacter_phage	5.1e-10	28.0
WP_171117865.1\|7908918_7909803_+	hypothetical protein	A0A1J0MCP9	Streptomyces_phage	5.6e-21	54.4
WP_171117863.1\|7909783_7910404_+	ATP-binding protein	NA	NA	NA	NA
WP_171119201.1\|7910418_7911765_+	AAA family ATPase	C7BGG1	Burkholderia_phage	3.3e-49	33.4

DBSCAN-SWA_8

8056280 : 8130106

Burkholderia_phage(13.33%)

protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_171107251.1\|8056280_8057081_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_171107253.1\|8057088_8057898_-	PhzF family phenazine biosynthesis protein	NA	NA	NA	NA
WP_171107254.1\|8058083_8058722_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_171107256.1\|8058789_8059218_-	SRPBCC family protein	NA	NA	NA	NA
WP_171107258.1\|8059543_8060089_+	peptidase	NA	NA	NA	NA
WP_171107260.1\|8060166_8061168_+	EamA family transporter	NA	NA	NA	NA
WP_171111315.1\|8061475_8062474_+	EamA family transporter	NA	NA	NA	NA
WP_171111316.1\|8062534_8063239_-	pyridoxamine 5'-phosphate oxidase family protein	NA	NA	NA	NA
WP_171107262.1\|8063296_8064619_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_171107264.1\|8064664_8064997_+	VOC family protein	NA	NA	NA	NA
WP_171107266.1\|8065097_8066039_-	DMT family transporter	NA	NA	NA	NA
WP_171107268.1\|8066102_8067005_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_171107269.1\|8067012_8067480_-	pyridoxamine 5'-phosphate oxidase family protein	NA	NA	NA	NA
WP_171107272.1\|8067610_8068252_+	cysteine hydrolase	NA	NA	NA	NA
WP_171107274.1\|8068255_8068717_-	Rieske (2Fe-2S) protein	NA	NA	NA	NA
WP_171107276.1\|8068844_8069600_+	hypothetical protein	NA	NA	NA	NA
WP_171111318.1\|8069605_8070022_+	DUF3037 domain-containing protein	NA	NA	NA	NA
WP_171107278.1\|8070157_8070919_+	3-oxoacyl-ACP reductase FabG	NA	NA	NA	NA
WP_171107280.1\|8070930_8071692_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_171107283.1\|8071920_8073501_+	peptide-binding protein	NA	NA	NA	NA
WP_171107285.1\|8073582_8074275_+	uracil-DNA glycosylase	V5NWU7	Chelonid_alphaherpesvirus	3.9e-46	42.5
WP_171107287.1\|8074391_8074913_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_171107289.1\|8074939_8075416_-	hypothetical protein	NA	NA	NA	NA
WP_171107291.1\|8075528_8076041_-	DinB family protein	NA	NA	NA	NA
WP_171107294.1\|8076082_8076700_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_171107296.1\|8076785_8077979_+	FAD-dependent monooxygenase	NA	NA	NA	NA
WP_171107298.1\|8077989_8078904_+	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_171107300.1\|8078818_8080378_-	apolipoprotein N-acyltransferase	NA	NA	NA	NA
WP_171107302.1\|8080485_8080965_-	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_171111320.1\|8081094_8081727_+	DUF4291 domain-containing protein	NA	NA	NA	NA
WP_171107304.1\|8081723_8082464_+	glucose 1-dehydrogenase	NA	NA	NA	NA
WP_171107306.1\|8082471_8082957_-	chloramphenicol phosphotransferase	NA	NA	NA	NA
WP_171107308.1\|8082956_8083136_-	hypothetical protein	NA	NA	NA	NA
WP_171134068.1\|8083787_8084087_+\|transposase	transposase	A9YX41	Burkholderia_phage	4.2e-05	36.2
WP_171134108.1\|8084083_8084971_+\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	6.4e-33	30.4
WP_171107243.1\|8085664_8086243_-	low molecular weight phosphatase family protein	NA	NA	NA	NA
WP_171107241.1\|8086239_8087712_-	polysaccharide biosynthesis tyrosine autokinase	A0A1X9I5E1	Streptococcus_phage	1.1e-08	27.8
WP_171114532.1\|8089810_8090362_+	glutaminyl-peptide cyclotransferase	NA	NA	NA	NA
WP_171134109.1\|8090438_8091572_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_171114534.1\|8091670_8092465_+	FkbM family methyltransferase	A0A291AUV0	Sinorhizobium_phage	1.1e-10	29.0
WP_171114535.1\|8092650_8093658_+	NAD-dependent epimerase/dehydratase family protein	A0A1V0SKV4	Klosneuvirus	8.6e-26	31.4
WP_171114536.1\|8093673_8094426_+	FkbM family methyltransferase	NA	NA	NA	NA
WP_171114537.1\|8094472_8095660_-	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_171114538.1\|8095660_8096404_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_171114539.1\|8096581_8097721_-	glycosyltransferase	NA	NA	NA	NA
WP_171114540.1\|8097717_8098416_-	WbqC family protein	NA	NA	NA	NA
WP_171118827.1\|8098412_8099063_-	PIG-L family deacetylase	NA	NA	NA	NA
WP_171114541.1\|8099080_8099575_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_171114542.1\|8099821_8101180_+	O-antigen ligase family protein	NA	NA	NA	NA
WP_171134110.1\|8101173_8102382_+	glycosyltransferase	NA	NA	NA	NA
WP_171114544.1\|8102378_8103326_+	NAD-dependent epimerase/dehydratase family protein	A0A0E3FNQ3	Synechococcus_phage	7.3e-27	33.0
WP_171114545.1\|8103354_8104830_-	hypothetical protein	NA	NA	NA	NA
WP_171118831.1\|8104856_8106119_-	nucleotide sugar dehydrogenase	A0A127AXI2	Bacillus_phage	4.7e-21	27.2
WP_171114546.1\|8106399_8107473_+	NAD-dependent epimerase/dehydratase family protein	A0A2H4UUK0	Bodo_saltans_virus	1.8e-29	33.3
WP_171114547.1\|8107469_8108669_+	undecaprenyl/decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase	NA	NA	NA	NA
WP_171114548.1\|8108741_8109887_+	glycosyltransferase	NA	NA	NA	NA
WP_171114549.1\|8109932_8111507_-	DUF4012 domain-containing protein	NA	NA	NA	NA
WP_171118832.1\|8112768_8113884_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_171072378.1\|8114866_8115175_+\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	2.9e-17	51.0
WP_171114550.1\|8115171_8115777_+\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	4.5e-22	38.5
WP_171114551.1\|8115773_8116091_+\|transposase	IS3 family transposase	Q6H9S3	Enterobacteria_phage	2.5e-11	44.6
WP_171134111.1\|8116157_8116700_+	winged helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_171134112.1\|8116624_8117227_+\|transposase	transposase	NA	NA	NA	NA
WP_171117373.1\|8117362_8118739_+\|transposase	IS1380 family transposase	A0A222ZN33	Mycobacterium_phage	7.0e-119	53.8
WP_171119119.1\|8119113_8120208_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_171134113.1\|8123370_8124258_-\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	6.4e-33	30.4
WP_171134068.1\|8124254_8124554_-\|transposase	transposase	A9YX41	Burkholderia_phage	4.2e-05	36.2
WP_171134114.1\|8124577_8124739_-	hypothetical protein	NA	NA	NA	NA
WP_171107312.1\|8124859_8126254_+	hypothetical protein	NA	NA	NA	NA
WP_171134153.1\|8126330_8126852_-	DUF4145 domain-containing protein	NA	NA	NA	NA
WP_171113162.1\|8129356_8130106_-\|transposase	transposase family protein	NA	NA	NA	NA

DBSCAN-SWA_9

8215709 : 8233632

Streptomyces_phage(78.57%)

tail,capsid,portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_171113031.1\|8215709_8216714_-	LysM peptidoglycan-binding domain-containing protein	A0A1J0MCQ0	Streptomyces_phage	3.3e-41	37.2
WP_171113029.1\|8216713_8217019_-	hypothetical protein	A0A142K8R1	Gordonia_phage	1.3e-25	59.8
WP_171134116.1\|8217083_8218850_-	right-handed parallel beta-helix repeat-containing protein	A0A1B1PAA2	Streptomyces_phage	2.3e-29	31.8
WP_171134117.1\|8218851_8219784_-	hypothetical protein	A0A291LI15	Streptomyces_phage	3.7e-15	31.0
WP_171110605.1\|8219787_8220942_-	hypothetical protein	A0A0K1Y9X6	Streptomyces_phage	1.0e-22	27.8
WP_171110604.1\|8220957_8221935_-\|tail	phage tail family protein	NA	NA	NA	NA
WP_171134118.1\|8221949_8224481_-\|tail	phage tail tape measure protein	A0A2H5BLS1	Streptomyces_phage	3.3e-58	45.6
WP_171111795.1\|8224541_8224751_-	hypothetical protein	A0A2K9VH90	Gordonia_phage	2.1e-11	54.7
WP_171110602.1\|8224747_8225281_-	hypothetical protein	NA	NA	NA	NA
WP_171110601.1\|8225280_8225754_-	hypothetical protein	NA	NA	NA	NA
WP_171110600.1\|8225763_8226207_-	hypothetical protein	A0A1J0MBT6	Streptomyces_phage	6.1e-08	36.1
WP_171111793.1\|8226203_8226503_-	hypothetical protein	A0A1V0E617	Streptomyces_phage	5.0e-22	57.1
WP_171110599.1\|8226566_8226887_-	hypothetical protein	K4I2V6	Streptomyces_phage	2.0e-13	40.2
WP_171110598.1\|8226886_8227552_-	hypothetical protein	A0A1J0MC98	Streptomyces_phage	1.1e-16	48.3
WP_171110597.1\|8227638_8228148_-	hypothetical protein	NA	NA	NA	NA
WP_171110596.1\|8228147_8228450_-	hypothetical protein	NA	NA	NA	NA
WP_171110595.1\|8228465_8228819_-	hypothetical protein	NA	NA	NA	NA
WP_171110594.1\|8228902_8229817_-	hypothetical protein	A0A222ZRM6	Mycobacterium_phage	3.2e-19	26.7
WP_171110593.1\|8229834_8230653_-	hypothetical protein	NA	NA	NA	NA
WP_171110592.1\|8230750_8231002_+	hypothetical protein	NA	NA	NA	NA
WP_171110591.1\|8230998_8232102_-\|capsid	capsid protein	A0A1J0MC53	Streptomyces_phage	5.4e-90	53.3
WP_171110590.1\|8232117_8233632_-\|portal	phage portal protein	A0A1J0MCC3	Streptomyces_phage	1.4e-104	43.9

DBSCAN-SWA_10

8244045 : 8257579

Streptomyces_phage(36.36%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_171108625.1\|8244045_8244612_-	3'-5' exoribonuclease	A0A0M5M6E2	Streptomyces_phage	6.7e-44	52.9
WP_171108627.1\|8244739_8244946_-	hypothetical protein	NA	NA	NA	NA
WP_171108629.1\|8245052_8245295_-	hypothetical protein	NA	NA	NA	NA
WP_171108631.1\|8245291_8246461_-	hypothetical protein	NA	NA	NA	NA
WP_171108633.1\|8246537_8246969_-	DUF4326 domain-containing protein	A0A142K9N0	Gordonia_phage	2.3e-28	48.3
WP_171108635.1\|8246965_8247337_-	hypothetical protein	NA	NA	NA	NA
WP_171108637.1\|8247392_8247590_-	hypothetical protein	NA	NA	NA	NA
WP_171108639.1\|8247593_8249375_-	AAA family ATPase	Q1WDH9	Streptomyces_phage	8.4e-133	48.1
WP_171108641.1\|8249386_8249695_-	hypothetical protein	NA	NA	NA	NA
WP_171108643.1\|8249694_8250513_-	DUF2303 family protein	C5IHK3	Burkholderia_virus	1.5e-28	36.2
WP_171108645.1\|8250515_8250884_-	hypothetical protein	A0A142K8T9	Gordonia_phage	1.8e-10	40.2
WP_171108647.1\|8251022_8251490_-	hypothetical protein	NA	NA	NA	NA
WP_171108649.1\|8251489_8251690_-	transcription factor WhiB	NA	NA	NA	NA
WP_171108650.1\|8251689_8252340_-	hypothetical protein	A0A0R8VCP1	Thermobifida_phage	1.9e-18	38.8
WP_171111438.1\|8252336_8253659_-	DNA cytosine methyltransferase	A0A142KCP3	Gordonia_phage	3.4e-62	40.8
WP_171111440.1\|8253658_8254282_-	hypothetical protein	Q1WDI4	Streptomyces_phage	3.3e-36	47.1
WP_171108652.1\|8254293_8254575_-	hypothetical protein	NA	NA	NA	NA
WP_171108654.1\|8254571_8255015_-	hypothetical protein	NA	NA	NA	NA
WP_171108656.1\|8255014_8255767_-	DNA polymerase III subunit epsilon	Q1WDI5	Streptomyces_phage	5.2e-44	43.2
WP_171108658.1\|8255763_8256537_-	ERF family protein	A0A0M4RQK0	Mycobacterium_phage	1.1e-31	44.2
WP_171134121.1\|8256538_8257579_-	YqaJ viral recombinase family protein	A0A142K7H9	Mycobacterium_phage	4.4e-17	30.2

DBSCAN-SWA_11

9410388 : 9437773

Burkholderia_phage(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_171118531.1\|9410388_9411597_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_171134068.1\|9411689_9411989_+\|transposase	transposase	A9YX41	Burkholderia_phage	4.2e-05	36.2
WP_171134108.1\|9411985_9412873_+\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	6.4e-33	30.4
WP_171117736.1\|9412924_9415153_+	RHS repeat-associated core domain-containing protein	NA	NA	NA	NA
WP_171117738.1\|9416159_9416411_-	hypothetical protein	NA	NA	NA	NA
WP_171117740.1\|9416437_9416884_+	SRPBCC family protein	NA	NA	NA	NA
WP_171119181.1\|9417274_9417511_-	hypothetical protein	NA	NA	NA	NA
WP_171117743.1\|9417802_9418339_-	hypothetical protein	NA	NA	NA	NA
WP_171134108.1\|9419509_9420397_-\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	6.4e-33	30.4
WP_171134068.1\|9420393_9420693_-\|transposase	transposase	A9YX41	Burkholderia_phage	4.2e-05	36.2
WP_171134134.1\|9420744_9421422_-	hypothetical protein	NA	NA	NA	NA
WP_171109924.1\|9421469_9421697_-	hypothetical protein	NA	NA	NA	NA
WP_171109923.1\|9422317_9422785_-	hypothetical protein	NA	NA	NA	NA
WP_171109922.1\|9422825_9423434_-	hypothetical protein	NA	NA	NA	NA
WP_171109921.1\|9423478_9423712_+	hypothetical protein	NA	NA	NA	NA
WP_171109920.1\|9423949_9424723_-	LuxR family transcriptional regulator	NA	NA	NA	NA
WP_171109919.1\|9424754_9426458_-	amidohydrolase	NA	NA	NA	NA
WP_171109918.1\|9426962_9427520_-	XRE family transcriptional regulator	NA	NA	NA	NA
WP_171107095.1\|9427802_9428201_+	hypothetical protein	NA	NA	NA	NA
WP_171111642.1\|9429487_9430606_+	beta-lactamase family protein	A0A1D8EXR7	Mycobacterium_phage	6.9e-24	31.2
WP_171109917.1\|9431567_9431840_-	hypothetical protein	NA	NA	NA	NA
WP_171109916.1\|9432403_9433945_+	von Willebrand factor type A domain-containing protein	NA	NA	NA	NA
WP_171109915.1\|9434613_9435066_-	MerR family transcriptional regulator	NA	NA	NA	NA
WP_171109914.1\|9435179_9436007_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_171109913.1\|9437040_9437367_-	hypothetical protein	NA	NA	NA	NA
WP_171134068.1\|9437473_9437773_+\|transposase	transposase	A9YX41	Burkholderia_phage	4.2e-05	36.2

Anti-CRISPR protein detection

Acr_ID: NZ_CP053109.1|WP_171113365.1|7639906_7640095_-|hypothetical-protein

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Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_CP053109.1|WP_171113365.1|7639906_7640095_-|hypothetical-protein

7639906_7640095_-

62 aa aa

7599206-7668930

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP053109_12	Orphan	12.2\|6623404\|19\|NZ_CP053109\|CRISPRCasFinder	6623404-6623422	19	7642301-7642283	2

1. spacer 12.2|6623404|19|NZ_CP053109|CRISPRCasFinder matches to NZ_CP053109 position: 7642301-7642283, mismatch: 2

gctagccgagggctacgcc	CRISPR spacer
gctcgccgagggcgacgcc	Protospacer
*** ********* *****

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP053109

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

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