CRISPRimmunity

Please click to download your results

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP049838	Streptomyces cacaoi subsp. asoensis strain H2S5 chromosome, complete genome	20 crisprs	WYL,csa3,DEDDh,cas4,c2c9_V-U4,Cas9_archaeal,cas3,DinG	6	9	4	6

Results visualization

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP049838_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049838_1

2246703-2246809

Orphan

Consensus_repeat	Method
CCGACGTTTGAGGACGAGGCCGTTCAGGCCGAAGGGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049838_1

>merge|NZ_CP049838|1|2246703-2246809|CRISPRCasFinder
CCGACGTTTGAGGACGAGGCCGTTCAGGCCGAAGGGGGTCTCGGCAGCGGCGCATCCACCCAGCCCGTCCCGACGTTTGAGGACGAGGCCGTTCAGGCCGAAGGGGG

>NZ_CP049838|1|1|2246703-2246809|CRISPRCasFinder
CCGACGTTTGAGGACGAGGCCGTTCAGGCCGAAGGGGG	TCTCGGCAGCGGCGCATCCACCCAGCCCGTC
CCGACGTTTGAGGACGAGGCCGTTCAGGCCGAAGGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049838.1\|WP_171396210.1\|2235354_2236368_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|379138
NZ_CP049838.1\|WP_171396211.1\|2236411_2237620_-\|type-VII-secretion-associated-serine-protease-mycosin	unknown	unknown	gnl\|CDD\|274856
NZ_CP049838.1\|WP_171401931.1\|2242322_2243708_-\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|365919
NZ_CP049838.1\|WP_171396219.1\|2248944_2249664_-\|cobalamin-binding-protein	unknown	unknown	gnl\|CDD\|238564
NZ_CP049838.1\|WP_171396220.1\|2249663_2250260_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP049838.1\|WP_171396213.1\|2241534_2242326_-\|3-oxoacyl-ACP-reductase	unknown	unknown	gnl\|CDD\|180371
NZ_CP049838.1\|WP_171396225.1\|2255843_2256620_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|130314
NZ_CP049838.1\|WP_171396208.1\|2234058_2234436_+\|DUF1844-domain-containing-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171396226.1\|2256616_2257633_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|130256
NZ_CP049838.1\|WP_171396224.1\|2254924_2255770_+\|siderophore-interacting-protein	unknown	unknown	gnl\|CDD\|99790
NZ_CP049838.1\|WP_171396221.1\|2250723_2252538_-\|ABC-transporter-permease/substrate-binding-protein	unknown	unknown	gnl\|CDD\|226644
NZ_CP049838.1\|WP_171396222.1\|2252530_2253616_-\|glycine-betaine/L-proline-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213261
NZ_CP049838.1\|WP_171396214.1\|2243761_2245126_-\|glutamine-synthetase	unknown	unknown	gnl\|CDD\|223252
NZ_CP049838.1\|WP_171396209.1\|2234471_2235203_-\|SseB-family-protein	unknown	unknown	gnl\|CDD\|377787
NZ_CP049838.1\|WP_171396218.1\|2247866_2249033_+\|TDT-family-transporter	unknown	unknown	gnl\|CDD\|187760
NZ_CP049838.1\|WP_171396215.1\|2245230_2245965_+\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_CP049838.1\|WP_171396217.1\|2246866_2247796_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176112
NZ_CP049838.1\|WP_171396212.1\|2240311_2241514_+\|amino-acid-deaminase/aldolase	unknown	unknown	gnl\|CDD\|143488
NZ_CP049838.1\|WP_171401930.1\|2237616_2238417_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171396223.1\|2253820_2254762_+\|5'-3'-exonuclease	unknown	unknown	gnl\|CDD\|214682

Protein	Function_ID	Function_description	E-value
NZ_CP049838.1\|WP_171396210.1\|2235354_2236368_+\|serine-hydrolase	gnl\|CDD\|379138	pfam13354, Beta-lactamase2, Beta-lactamase enzyme family. This family is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	0.000124005
NZ_CP049838.1\|WP_171396211.1\|2236411_2237620_-\|type-VII-secretion-associated-serine-protease-mycosin	gnl\|CDD\|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	5.7548e-109
NZ_CP049838.1\|WP_171401931.1\|2242322_2243708_-\|aldehyde-dehydrogenase	gnl\|CDD\|365919	pfam00171, Aldedh, Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.	0
NZ_CP049838.1\|WP_171396220.1\|2249663_2250260_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	9.56921e-11
NZ_CP049838.1\|WP_171396213.1\|2241534_2242326_-\|3-oxoacyl-ACP-reductase	gnl\|CDD\|180371	PRK06057, PRK06057, short chain dehydrogenase; Provisional.	0
NZ_CP049838.1\|WP_171396225.1\|2255843_2256620_-\|ABC-transporter-permease	gnl\|CDD\|130314	TIGR01247, drrB, daunorubicin resistance ABC transporter membrane protein. This model describes daunorubicin resistance ABC transporter, membrane associated protein in bacteria and archaea. The protein associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	5.19305e-24
NZ_CP049838.1\|WP_171396226.1\|2256616_2257633_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|130256	TIGR01188, drrA, daunorubicin resistance ABC transporter ATP-binding subunit. This model describes daunorubicin resistance ABC transporter, ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	4.50793e-106
NZ_CP049838.1\|WP_171396224.1\|2254924_2255770_+\|siderophore-interacting-protein	gnl\|CDD\|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	8.18887e-97
NZ_CP049838.1\|WP_171396221.1\|2250723_2252538_-\|ABC-transporter-permease/substrate-binding-protein	gnl\|CDD\|226644	COG4176, ProW, ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism].	5.45461e-126
NZ_CP049838.1\|WP_171396222.1\|2252530_2253616_-\|glycine-betaine/L-proline-ABC-transporter-ATP-binding-protein	gnl\|CDD\|213261	cd03294, ABC_Pro_Gly_Betaine, ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system. This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporters is the obligatory coupling of ATP hydrolysis to substrate translocation. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	7.09198e-163
NZ_CP049838.1\|WP_171396215.1\|2245230_2245965_+\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	9.61919e-39
NZ_CP049838.1\|WP_171396209.1\|2234471_2235203_-\|SseB-family-protein	gnl\|CDD\|377787	pfam07179, SseB, SseB protein N-terminal domain. This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon. This entry contains the presumed N-terminal domain of SseB.	2.39532e-19
NZ_CP049838.1\|WP_171396218.1\|2247866_2249033_+\|TDT-family-transporter	gnl\|CDD\|187760	cd09320, TDT_like_2, The Tellurite-resistance/Dicarboxylate Transporter (TDT) family. The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane alpha-helical spanners (TMSs).	3.25544e-99
NZ_CP049838.1\|WP_171396219.1\|2248944_2249664_-\|cobalamin-binding-protein	gnl\|CDD\|238564	cd01144, BtuF, Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains. In addition, these proteins sometimes have a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence).	1.00498e-54
NZ_CP049838.1\|WP_171396217.1\|2246866_2247796_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176112	cd08420, PBP2_CysL_like, C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold. CysL, also known as YwfK, is a regular of sulfur metabolism in Bacillus subtilis. Sulfur is required for the synthesis of proteins and essential cofactors in all living organism. Sulfur can be assimilated either from inorganic sources (sulfate and thiosulfate), or from organic sources (sulfate esters, sulfamates, and sulfonates). CysL activates the transcription of the cysJI operon encoding sulfite reductase, which reduces sulfite to sulfide. Both cysL mutant and cysJI mutant are unable to grow using sulfate or sulfite as the sulfur source. Like other LysR-type regulators, CysL also negatively regulates its own transcription. In Escherichia coli, three LysR-type activators are involved in the regulation of sulfur metabolism: CysB, Cbl and MetR. The topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.55043e-64
NZ_CP049838.1\|WP_171396212.1\|2240311_2241514_+\|amino-acid-deaminase/aldolase	gnl\|CDD\|143488	cd06813, PLPDE_III_DSD_D-TA_like_2, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2. This subfamily is composed of uncharacterized bacterial proteins with similarity to eukaryotic D-serine dehydratases (DSD) and D-threonine aldolases (D-TA). DSD catalyzes the dehydration of D-serine to aminoacrylate, which is rapidly hydrolyzed to pyruvate and ammonia. D-TA reversibly catalyzes the aldol cleavage of D-threonine into glycine and acetaldehyde, and the synthesis of D-threonine from glycine and acetaldehyde. DSD and D-TA are fold type III PLP-dependent enzymes, similar to bacterial alanine racemase (AR), which contains an N-terminal PLP-binding TIM barrel domain and a C-terminal beta-sandwich domain. AR exists as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Based on their similarity to AR, it is possible members of this family also form dimers in solution.	0
NZ_CP049838.1\|WP_171396214.1\|2243761_2245126_-\|glutamine-synthetase	gnl\|CDD\|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	7.06525e-142
NZ_CP049838.1\|WP_171396223.1\|2253820_2254762_+\|5'-3'-exonuclease	gnl\|CDD\|214682	smart00475, 53EXOc, 5'-3' exonuclease.	6.60643e-82

>NZ_CP049838.1|WP_171396215.1|2245230_2245965_+|FadR-family-transcriptional-regulator
MSVDADGGPDDRLTPVLRPVRAGNGFEEALEQILQVVRLGLVPGGERLPAERDLAERLGISRVTLREVLKVLQDQGLVESRRGRYGGTFVLPRTDAGGEDELRRRIAEVDIEDVLRFREVLEVGAAGLCATHGLTDEQAERLREALARTADAPLADYRRLDTMLHLTLAELCGSPSLTAQYAAVRATVNDLLDCIPLLVRNLEHSQRQHLALVEAVLDGDADGAREMMREHCAGTAALLRGFLT
>NZ_CP049838.1|WP_171396214.1|2243761_2245126_-|glutamine-synthetase
MADRTPPLSVEELHAHVASGEIDTVVLAFPDMQGRLQGKRFAAGFFLDEVLQHGTEGCNYLLAVDTEMNTVDGYAMSSWERGYGDFAMRPDLSTLRRVPWNAGTALLIADLAWNDGSPVVAAPRQILRRQLERLAGHGFTAQVGTELEFIVFKDSYEAAWDANYRGLTPVNQYNVDYSVLGTGRVEPLLRRIRNEMAGAGLTVESAKGECNPGQHEIAFRYDEALVTCDQHAIYKTGAKEIAAQEGVSLTFMAKYNEREGNSCHIHLSLTDADGTNVMAGDGEGGMSDVMRHFLAGQLAALRDFSLLYAPNINSYKRFQPGSFAPTAVAWGYDNRTCSLRVVGHGRSMRFENRLPGGDVNPHLAVAGLVAAGLYGIEQKLELPEACPGNAYTAEYAHVPTTLREAAELWANSPIALAAFGEEVVAHYRNMARVELEAFDAAVTDWELRRSFERL
>NZ_CP049838.1|WP_171401931.1|2242322_2243708_-|aldehyde-dehydrogenase
MSDPQSLAHELIVLNPATEEIVATVPAADAADVDRAVARASTAQKAWAAAAPADRARLLRRFADVVDAHVEELALLEVREAGHLLGNARWEAGNARDLLLYAAGGVERLLGRQIPVPGGWNVTFQEPLGVVGVIAPWNFPMPIAAWGSFPALAAGNAVVLKPAETTPLTALRLAELALEAGLSEHLFQVLPGHGAVAGRALVDHPGVAKIVFTGSTRTGREVMERCARQVKPVTLELGGKSPNIVFADADLKAAVDPFSFLDNSGQDCCARTRVLVQESVYEEVADHLARELAAVTVGDPADEKTRMGPLISRQQVDRVRSFVPDDAEALRGTAPDGPGFWFPPTVLTGVAPDSPAAREEIFGPVAVLLPFTDEADAIRLADDTPYGLSGSIWTRDVGRALRVSQAVRAGNLSVNSHSSVRYWTPFGGYKQSGVGRELGPDALTAFTETKNVFISTEGPAQ
>NZ_CP049838.1|WP_171396213.1|2241534_2242326_-|3-oxoacyl-ACP-reductase
MTASPDEIICRRLVGRTAVITGAGSGIGLATARRLASEGAHVVCGDVDETRGKAAAEEVGGTFVKVDVTDPEQVEALFQAAYDTYGSVDIAFNNAGISPPDDDSILETGLEAWKRVQEVNLTSVYLCCKAAIPYMRRQGRGSIINTASFVARMGAATSQISYTASKGGVLAMSRELGVQFAREGIRVNALCPGPVNTPLLQELFAKDPERAARRLVHIPVGRFAEAEEIAAAVAFLASDDSSFVNASDFLVDGGISGAYVTPL
>NZ_CP049838.1|WP_171396212.1|2240311_2241514_+|amino-acid-deaminase/aldolase
MTARAADRARYDRATAHLDAPLALVDLDAFDANAEDLVRRAGGKPIRVASKSVRCRTLLERVLAKDGFAGIMSFTLAESLWLARSGFEDILLAYPSADRTAFAELAADPKLAAAVTVMVDDVSQLDLIDGARGEGREVIRVCLELDTALKLLGGRVRVGALRSPLHSPAQVADVARAVARRPGFKLVGIMAYEGHIAGVGDAVAGRPFRSRAIRLMQATARRELAERRAAVVRAVRAVVPDLEYVNGGGTGSVQHTAAEDAVTEIAAGSGLYVPRLFDNYTSFSGRPAALFAQPVVRRPGVGIVTVLGGGYPASGAAGPDRLPVPYLPEGLRYDPQEGPGEVQTPLLGSPADDLLIGDKVWFRHAKAGELCERFDVLHLVEGDAVTATVPTYRGEGQTFL
>NZ_CP049838.1|WP_171401930.1|2237616_2238417_-|hypothetical-protein
MTFARPEVYRDTPRTFGRRGRVAAAAACVVLGMGLIGGAVTGSWLVGDSADAAERSTYTTAGGLWHNVPVDQLFPPTVDGQGAGPGGADRTWTRIAVAPDGGCADAFDPLLLKALAPVGCQRLLRATYTDATQSYVTTVGLLFTTADAAAMRSLDTRFTKEKLAERTDLMPRPYAAKGTVAAAFGDKQRAAWTVSVLTDAPVVVYAVSGWADGRVVDTPQPAPVATAAGATTAPAQAGLGNEAQGLADRIERGLRKTAVTPSEQPS
>NZ_CP049838.1|WP_171396211.1|2236411_2237620_-|type-VII-secretion-associated-serine-protease-mycosin
MSTRTTRTTRRAGLLCCLLAATVALVPPSTAYADGIRAKQWALEALHTEEAWQTTKGGGITVAVLDTGVEADHPDLTGNVLTGKDMVGFGAGPGDRAWARHGTAMAGIIAGHGHGNGNADGVLGIAPEAKILPVRVILEDGDPQRTKARNTRGNALAEGIRWAADQGADVINLSLGDDSASAHPEPAEDEAVQYALKKGSVVVASAGNGGEKGDHISYPAAYPGVIAATAVDRYGTRASFSTRRWYATVSAPGVDVVIADPDHKYYEGWGTSAASAFVSGAVALIKGAHPGLTPAQIKKLLEDTARNSPTGGRDDSRGYGLIDPAAAITAAADLKPEGLQSAAYGEQYFGSGPDEPKADDDPAGWAGLLAGGAGGVLLVTAVFLWRGRRERDRPEAYEALQP
>NZ_CP049838.1|WP_171396210.1|2235354_2236368_+|serine-hydrolase
MESSRARRGRRAHPSRRRPLLYTALAAVAVLGATAGGTVYVKAQAHSGTGAVSSSSATPSASGSGSGSGSGKVSVETVAAPEVDHDALLASAMKSVTVPGDAAVSAAVLDLDSGDDATYGESAFDTASIVKVDILATLLLQAQDADRYLTAAEKTYATAMIENSDNDSASALWRIIGKAEGLDAANERFGLTDTAGGDDMLWGLTQTTAADQLILLRQVFGDDSELSEASRTYLQGLMGQIAVDQRWGVSAAADGSSWALKNGWLARSTTGLWDINSIGRVTVDGHDCLVAVLSNGNATQTAGISLVEQVARAAVSTLRDGGASASASASASPSAAD
>NZ_CP049838.1|WP_171396209.1|2234471_2235203_-|SseB-family-protein
MANKNIPDSGFSDDDGSADPRLSAALAAWAEDRTAVGPVLAALKGARLLVPVVAVLGEVEEDEKGLRREKTSDMAVPTLKAGARTALPAFTSTDSLARWDPEARPVAVPLHQALQAAAHEKADTVVLDLAGPVAFELTGPALLALAEGRTSIDPLADPAVRAAVRAAVAAEPEVLSAHLGPGQADGTLALVLDPAAVPAEAARAVAGRLAADETLRARLVRGLDLALLPAGTTPPGEPLYVKS
>NZ_CP049838.1|WP_171396208.1|2234058_2234436_+|DUF1844-domain-containing-protein
MSETSPAGSAETPGTPDFDEMTRDIAEVPAVEVIVTVAVNLMSAAAVKLGLTEEGDKYKDLDEARKLIHALAGLLDGSATEISSFHAAPLRDGLKSLQLAFREASLVPDEPGQGPGEKYTGPIYG
>NZ_CP049838.1|WP_171396217.1|2246866_2247796_-|LysR-family-transcriptional-regulator
MGSVEEQPADTASGSIAHRVPDLGALELLLAVARLGSLGAAARELGITQPAASSRIRSMERQLGVALVDRSPRGSRLTDTGALVTDWAGRVVEAARAFDAGAQALRVRRDSRLRVAASMTIAEYLLPGWLLALRAGRPDTAVSLLAGNSAAVAERLLSGEADLGFVEGLTVPPGLDSAVIAHDHLIVVVAPAHPWARRRRPLPAAELASTPLILREKGSGTRQVLDTALGGLARPLIELSSTTAVKAAAVSGAGPAVLSELAVGEELGLRRLVKVPVEGVALARDLRAVWPTGHRPAGPARELLSLTRG
>NZ_CP049838.1|WP_171396218.1|2247866_2249033_+|TDT-family-transporter
MVTAAQPLYALPRVRAGAVRHLGPNWYATVMGTAILATAGAALPVRPPGLRPLLTACWVLALVLLLALLGARALHWRHHRDQARAHLLDPATAPFYGCLAMALLAVGGGALTVGRDWIGIRAAVALDAVLFTVGTAVALAAAVSVPYLMAVRHRVRASQATPVWLLPLVAPMVSAALGPLLVPYLPAGQPRQTLLLACFALFGLSLLATLVMLPVVFARLVTGGPLPLVLTPTLFLVLGPLGQSTTAVGKFAEVAPGVLPGPDSRGLAVLAVLYGVPVMGFALFWLCLATAHVVRARRHGMGFAMTWWAFTFPVGTCVTGAAALARHTGLVAYDVLACALYVVLVAAWIVAATHTVRGLLSGVLLAAPRPAPSAPRRATGRTTSGAVR
>NZ_CP049838.1|WP_171396219.1|2248944_2249664_-|cobalamin-binding-protein
MRIVSLVPSLTEAVASSVPGALIGATDWCTHPAGLDVTRIGGTKNPRVDRIVALAPDLVIANEEENREPDLAALRTAGLEVLVTDIRDVPQAFGELARVLRACGVPSRPKWLDEAEEAWAAPLPPTRRRTAVVPIWRRPWMVLGRDTFAGDALARLGVDQLYAGHAERYPRIPVEELIAAAPDLVVLPDEPYRFTADDGPEAFPGLPCALLSGRHLTWYGPSLAEAPKVLGEALRAAHR
>NZ_CP049838.1|WP_171396220.1|2249663_2250260_-|helix-turn-helix-transcriptional-regulator
MGDHKEQPLRVGAAVRRRRRSLELTLAVVAERSGLSVPFLSQIENERARPSTSSLEKVADALRTTAVELLAAADPACSVDVVRAEVTEPGPGPEPEPEPRSRSLVRGHHQMHASEFTGDHDAGREFQYRNDQLMYVADGAVEIEAEGRAYRLGRGDTLYLTGGVRHRWRATVPDTRVVVVAVAEHIEAVRDRDRGRKR
>NZ_CP049838.1|WP_171396221.1|2250723_2252538_-|ABC-transporter-permease/substrate-binding-protein
MPRLHLGDWVDSGVDWLVTHMSWLFDAIKTVVEGMYDGLDTVLTAPEPLLLAGILAVLAWWLRGLVAGVLAFAGFALIDSLGLWDEAMSTLSLVLVATVIALAVSLPLGIWAARSKAVSATLRPVLDLLQTMPSMVLLIPAILFFGMGVPAGVIATLIFALAPGVRMTELGIRQVDAELVEAAEAFGTTPRDTLLRVQLPLALPTIMAGINQVIMLGLSMVVIAGMVGTGGLGGAVNEAIGQLDIGLGFEAGLGIVVLAIYLDRMTGALGTRISPLGRRAAAKARGTVWTYRPRPAVAVVGVVVLALVAGGMNVFGPSSGTAEASATDIGKGKEVKIGYIPWDEGIASTYLWKELLEERGFDVTTTQYTAGPLYTGVATGQIDFQTDAWLPTTHNEYWKKYGEQLDDLGSWYGPTSLELAVPSYVKDVGSLADLKSHAAEFDGKITGIEPSAGMMGLLKDKVLGQYGLDGAYTVVDGSTPAMLAELKRAYAAKKPIVVTLWSPHWAYSDYDLKKLEDPKGAWGKGDGVHTVARKDFAADNPEVGKWLKDFRMTEAQLTGLEARIQKAGKGKEQDAVRTWLKENPGLVEKWVPVADSGQESRAAR
>NZ_CP049838.1|WP_171396222.1|2252530_2253616_-|glycine-betaine/L-proline-ABC-transporter-ATP-binding-protein
MSSRLEAEHLHKVFGRRPQQAVERLREGADREELRADGTTAAVIDASFAVEPGEIFVVMGLSGSGKSTLLRMLNGLLEPTAGRVLFDGQNLTALADRELRAVRAKKISMVFQHFALFPHRSVLDNAAYGLAVQGVPRREREERAVEALRLCGLAGWEKSWPDELSGGMQQRVGLARALATDADLLLMDESFSALDPLIRRDMQDQLLTLQQTLKKTIVFITHDLNEAMRLGDRIAVMRDGRIVQTGTAEDILIRPANDYVASFIQDVDRSRVLTASAVMDTVVRGDEADCGCETATSDTPFAALCALSARLTHPVAVLDGKRKLVGVVSGERLVRFLGDEQGQVTACDSPRDGGRKVLTRA
>NZ_CP049838.1|WP_171396223.1|2253820_2254762_+|5'-3'-exonuclease
MMRGVTGRLMLLDTASLYFRAYFGVPDSVKAPDGTPVNAVRGLLDFIDRLVKDHRPDELVACMDADWRPQWRVDLIPSYKAHRVAEERETGPDEEEVPDTLSPQVPIIEAVLDALGIARVGVAGYEADDVIGTFTGRSKGPVDIVTGDRDLYQLVDDARGVRVLYPLKGVGTLQLTDEAWLREKYGVDGSGYADLALLRGDPSDGLPGVPGIGEKTAAKLLAEFGDLAGIVAAVDDPRAKLTPSQRSRLDESRPYLAVAPKVVKVADDVPLPDVDTALPHAPRDGATLEALARRWGLGGSLQRLLTTLGAPPA
>NZ_CP049838.1|WP_171396224.1|2254924_2255770_+|siderophore-interacting-protein
MAERPARKPRKPHSAQVVRTERLTPHMQRVVLGGEGLADFTAGTCTDHYVKLLFGPEGVTYPEPFDLERIRAEFPREQWPVTRTYTVRNWDAELRELTLDFVVHGDEGLAGPWAARVQPGETVRFMGPGGAYAPDTAADWHLLAGDESALPAIAAALESLPAGSVAHAFIEVSGPEEEQKVDSDVEVVWLHRGDRPVGERLVEAVRALEFPEGRLHAFVHGEAACVKELRKLLRVELQIPREDLSISGYWRLGHNEDGWQASKRDWNARVEAEQEGAAPAA
>NZ_CP049838.1|WP_171396225.1|2255843_2256620_-|ABC-transporter-permease
MSTAIVQTWYMTQRQLMVFARQPAYAVITLIQPVIWLFLFGSLFKNVVALGGFGTASYLDYLVPGVVVMSALASNLWAGMGTLEEIQRGTLNRFLTTPASRAALMNGNVVHNGIVTALQSAVIVLLGLAGGAEYPGGVVGVVVLVVASVLLGTVFGALSNALGMLVRERESIIGVNTFLLLPLTFLSSAFMAPDRMPGWIRQVARFNPLDWAMVAGRSALSADPDWGAVLLRGGALLGLATAAVWLSIRTFRSYQRSV
>NZ_CP049838.1|WP_171396226.1|2256616_2257633_-|ATP-binding-cassette-domain-containing-protein
MSNTSAPAVEARRLVKTYPGGVTALNGLEITVEPGTVFGLLGPNGAGKSTAVKILTTLARPDSGSATVAGHDVLRHPDRVRRAIGVVAQNSGADPVATGRDNLRLQGRLYGVRGAALDRRVDELLERFALSEAARRPVKGYSGGMRRRLDVALGLVHRPEVLFLDEPTTGLDPEARTAMWDEIGRLAGEEGLTILLTTHYLEEADRLAERVAIVDRGRIVVTGTPDSLKGELRGDAVHVELRTALGESGRVLLEGALGGLPGVHEVVFDGPRVSVRAEDGAAAVPALLGALERAGVAVATATVARPSLDDVYLRYAGRRYAEAESGTADALVLAGGAR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP049838_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049838_2

2685132-2685256

Orphan

Consensus_repeat	Method
CTCGAACTGACCGGCAAGGAGCTGCGCTGATGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049838_2

>merge|NZ_CP049838|2|2685132-2685256|CRISPRCasFinder
CTCGAACTGACCGGCAAGGAGCTGCGCTGATGATCCCGGCTCACACACGGACCCGCTGGGGGTCCGGGGGTCGCCCCCCGGGAAGACACAGTCTCGAACTGACCGGCAAGGAGCTGCGCCGATGA

>NZ_CP049838|2|2|2685132-2685256|CRISPRCasFinder
CTCGAACTGACCGGCAAGGAGCTGCGCTGATGA	TCCCGGCTCACACACGGACCCGCTGGGGGTCCGGGGGTCGCCCCCCGGGAAGACACAGT
CTCGAACTGACCGGCAAGGAGCTGCGCCGATGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049838.1\|WP_171396562.1\|2680996_2682418_-\|Fe-S-cluster-assembly-protein-SufB	unknown	unknown	gnl\|CDD\|131035
NZ_CP049838.1\|WP_171396574.1\|2695653_2696787_+\|glucose-6-phosphate-dehydrogenase-assembly-protein-OpcA	unknown	unknown	gnl\|CDD\|213538
NZ_CP049838.1\|WP_171396561.1\|2679758_2680940_-\|Fe-S-cluster-assembly-protein-SufD	unknown	unknown	gnl\|CDD\|223791
NZ_CP049838.1\|WP_171396563.1\|2682414_2683158_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|225222
NZ_CP049838.1\|WP_171401950.1\|2694133_2695657_+\|glucose-6-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|235579
NZ_CP049838.1\|WP_020130533.1\|2678669_2679434_-\|Fe-S-cluster-assembly-ATPase-SufC	unknown	unknown	gnl\|CDD\|223473
NZ_CP049838.1\|WP_171396560.1\|2677416_2678673_-\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|131034
NZ_CP049838.1\|WP_171396569.1\|2687911_2689018_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|368185
NZ_CP049838.1\|WP_062649697.1\|2676930_2677398_-\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	unknown	unknown	gnl\|CDD\|273918
NZ_CP049838.1\|WP_171396575.1\|2696783_2697566_+\|6-phosphogluconolactonase	unknown	unknown	gnl\|CDD\|273494
NZ_CP049838.1\|WP_171396567.1\|2686080_2687091_+\|COX15/CtaA-family-protein	unknown	unknown	gnl\|CDD\|224528
NZ_CP049838.1\|WP_171396572.1\|2690890_2692978_+\|transketolase	unknown	unknown	gnl\|CDD\|223100
NZ_CP049838.1\|WP_171396571.1\|2689548_2690472_-\|protoheme-IX-farnesyltransferase	unknown	unknown	gnl\|CDD\|235293
NZ_CP049838.1\|WP_171396559.1\|2675678_2676518_+\|AbfB-domain-containing-protein	unknown	unknown	gnl\|CDD\|377497
NZ_CP049838.1\|WP_171396573.1\|2693011_2694130_+\|transaldolase	unknown	unknown	gnl\|CDD\|235117
NZ_CP049838.1\|WP_020130530.1\|2676601_2676934_-\|metal-sulfur-cluster-assembly-factor	unknown	unknown	gnl\|CDD\|225062
NZ_CP049838.1\|WP_171396568.1\|2687146_2687893_-\|nucleotidyltransferase	unknown	unknown	unknown
NZ_CP049838.1\|WP_171396570.1\|2689093_2689450_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171396564.1\|2683341_2684142_+\|AAC(3)-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|376807
NZ_CP049838.1\|WP_020130534.1\|2679441_2679759_-\|non-heme-iron-oxygenase-ferredoxin-subunit	unknown	unknown	gnl\|CDD\|239604

Protein	Function_ID	Function_description	E-value
NZ_CP049838.1\|WP_171396562.1\|2680996_2682418_-\|Fe-S-cluster-assembly-protein-SufB	gnl\|CDD\|131035	TIGR01980, UPF0051_protein_slr0074, FeS assembly protein SufB. This protein, SufB, forms a cytosolic complex SufBCD. This complex enhances the cysteine desulfurase of SufSE. The system, together with SufA, is believed to act in iron-sulfur cluster formation during oxidative stress. Note that SufC belongs to the family of ABC transporter ATP binding proteins, so this protein, encoded by an adjacent gene, has often been annotated as a transporter component. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_CP049838.1\|WP_171396574.1\|2695653_2696787_+\|glucose-6-phosphate-dehydrogenase-assembly-protein-OpcA	gnl\|CDD\|213538	TIGR00534, Putative_OxPP_cycle_protein_OpcA, glucose-6-phosphate dehydrogenase assembly protein OpcA. The opcA gene is found immediately downstream of zwf, the glucose-6-phosphate dehydrogenase (G6PDH) gene, in a number of species, including Mycobacterium tuberculosis, Streptomyces coelicolor, Nostoc punctiforme, and Synechococcus sp. PCC 7942. In the latter, disruption of opcA was shown to block assembly of G6PDH into active oligomeric forms. [Protein fate, Protein folding and stabilization].	2.00916e-95
NZ_CP049838.1\|WP_171396561.1\|2679758_2680940_-\|Fe-S-cluster-assembly-protein-SufD	gnl\|CDD\|223791	COG0719, SufB, Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones].	2.53851e-88
NZ_CP049838.1\|WP_171396563.1\|2682414_2683158_-\|transcriptional-regulator	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	2.75996e-53
NZ_CP049838.1\|WP_171401950.1\|2694133_2695657_+\|glucose-6-phosphate-dehydrogenase	gnl\|CDD\|235579	PRK05722, PRK05722, glucose-6-phosphate 1-dehydrogenase; Validated.	0
NZ_CP049838.1\|WP_020130533.1\|2678669_2679434_-\|Fe-S-cluster-assembly-ATPase-SufC	gnl\|CDD\|223473	COG0396, sufC, Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones].	1.51284e-142
NZ_CP049838.1\|WP_171396560.1\|2677416_2678673_-\|cysteine-desulfurase	gnl\|CDD\|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_CP049838.1\|WP_171396569.1\|2687911_2689018_-\|amidohydrolase-family-protein	gnl\|CDD\|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	2.74712e-10
NZ_CP049838.1\|WP_062649697.1\|2676930_2677398_-\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	gnl\|CDD\|273918	TIGR01994, Iron-sulfur_cluster_assembly_scaffold_protein_IscU, SUF system FeS assembly protein, NifU family. Three iron-sulfur cluster assembly systems are known so far. ISC is broadly distributed while NIF tends to be associated with nitrogenase in nitrogen-fixing bacteria. The most recently described is SUF, believed to be important to maintain the function during aerobic stress of enzymes with labile Fe-S clusters. It is fairly widely distributed. This family represents one of two different proteins proposed to act as a scaffold on which the Fe-S cluster is built and from which it is transferred. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	3.36922e-62
NZ_CP049838.1\|WP_171396575.1\|2696783_2697566_+\|6-phosphogluconolactonase	gnl\|CDD\|273494	TIGR01198, 6-phosphogluconolactonase_6PGL., 6-phosphogluconolactonase. This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway].	3.56617e-85
NZ_CP049838.1\|WP_171396567.1\|2686080_2687091_+\|COX15/CtaA-family-protein	gnl\|CDD\|224528	COG1612, CtaA, Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones].	4.68121e-27
NZ_CP049838.1\|WP_171396572.1\|2690890_2692978_+\|transketolase	gnl\|CDD\|223100	COG0021, TktA, Transketolase [Carbohydrate transport and metabolism].	0
NZ_CP049838.1\|WP_171396571.1\|2689548_2690472_-\|protoheme-IX-farnesyltransferase	gnl\|CDD\|235293	PRK04375, PRK04375, protoheme IX farnesyltransferase; Provisional.	1.42993e-147
NZ_CP049838.1\|WP_171396559.1\|2675678_2676518_+\|AbfB-domain-containing-protein	gnl\|CDD\|377497	pfam05270, AbfB, Alpha-L-arabinofuranosidase B (ABFB) domain. This family consists of several fungal alpha-L-arabinofuranosidase B proteins. L-Arabinose is a constituent of plant-cell-wall poly-saccharides. It is found in a polymeric form in L-arabinan, in which the backbone is formed by 1,5-a- linked l-arabinose residues that can be branched via 1,2-a- and 1,3-a-linked l-arabinofuranose side chains. AbfB hydrolyzes 1,5-a, 1,3-a and 1,2-a linkages in both oligosaccharides and polysaccharides, which contain terminal non-reducing l-arabinofuranoses in side chains.	1.34668e-53
NZ_CP049838.1\|WP_171396573.1\|2693011_2694130_+\|transaldolase	gnl\|CDD\|235117	PRK03343, PRK03343, transaldolase; Validated.	0
NZ_CP049838.1\|WP_020130530.1\|2676601_2676934_-\|metal-sulfur-cluster-assembly-factor	gnl\|CDD\|225062	COG2151, PaaD, Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only].	5.29297e-33
NZ_CP049838.1\|WP_171396564.1\|2683341_2684142_+\|AAC(3)-family-N-acetyltransferase	gnl\|CDD\|376807	pfam02522, Antibiotic_NAT, Aminoglycoside 3-N-acetyltransferase. This family consists of bacterial aminoglycoside 3-N-acetyltransferases EC:2.3.1.81, these catalyze the reaction: Acetyl-Co + a 2-deoxystreptamine antibiotic <=> CoA + N3'-acetyl-2-deoxystreptamine antibiotic. The enzyme can use a range of antibiotics with 2-deoxystreptamine rings as acceptor for its acetyltransferase activity, this inactivates and confers resistance to gentamicin, kanamycin, tobramycin, neomycin and apramycin amongst others.	1.47682e-103
NZ_CP049838.1\|WP_020130534.1\|2679441_2679759_-\|non-heme-iron-oxygenase-ferredoxin-subunit	gnl\|CDD\|239604	cd03528, Rieske_RO_ferredoxin, Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable microorganisms to tolerate and even exclusively utilize aromatic compounds for growth. ROs consist of two or three components: reductase, oxygenase, and ferredoxin (in some cases) components. The ferredoxin component contains either a plant-type or Rieske-type [2Fe-2S] cluster. The Rieske ferredoxin component in this family carries an electron from the RO reductase component to the terminal RO oxygenase component. BPDO degrades biphenyls and polychlorinated biphenyls. BPDO ferredoxin (BphF) has structural features consistent with a minimal and perhaps archetypical Rieske protein in that the insertions that give other Rieske proteins unique structural features are missing. CARDO catalyzes dihydroxylation at the C1 and C9a positions of carbazole. Rieske ferredoxins are found as subunits of membrane oxidase complexes, cis-dihydrodiol-forming aromatic dioxygenases, bacterial assimilatory nitrite reductases, and arsenite oxidase. Rieske ferredoxins are also found as soluble electron carriers in bacterial dioxygenase and monooxygenase complexes.	8.13961e-51

>NZ_CP049838.1|WP_171396564.1|2683341_2684142_+|AAC(3)-family-N-acetyltransferase
MPTPPPTGPLVTRDTLAAELRALGVEPGEILLVHSSLSSLGWVCGGAVAVVRGLLDAVGPDGTLVVPTQSGDLSDPALWSNPPVPADWWERIRATMPAYDPLITPALGVGVIPETVRTWPGALRSAHPQTSFAALGARAAELVEGHAPDCRLGEHSPLARLEKAGARVLLLGAGYATCTSFHLAEYRIPAPLVAVGRPGPGGTWEVVTEVSIDSDRFDELGHDFERDRDVVRGTVGAADVRLFPVADAVAYAQRWLPLHRSREEEL
>NZ_CP049838.1|WP_171396563.1|2682414_2683158_-|transcriptional-regulator
MKYVGEARETPTGTPQEEIATGERSTRNRVARSILDHGPSTVAELAGRLGLTQAAVRRHLDALVADDVVAAREQRVYGARTRGRPAKAFALTDCGRDAFDQSYDKLAADALRWIQERFGGDEAVVAFARARIAEQAAGYREAIEAAAPEERTEALAKALSADGYAATARSAPVGEQLCQHHCPVAHVAEKFPQLCEAETEIFSQLLGTHVQRLATIAHGDGVCTTFIPKVSTATHNASASTAGRNPA
>NZ_CP049838.1|WP_171396562.1|2680996_2682418_-|Fe-S-cluster-assembly-protein-SufB
MTLPTETAHPELEGLGKYEYGWADSDTAGASAKRGINEDVVKDISAKKSEPEWMTKLRLKGLRLFGKKPMPNWGSDLSGIDFDNIKYFVRSTEKQAESWEDLPEDIKNTYDKLGIPEAEKQRLVAGVAAQYESEVVYHQIREDLEEQGVIFLDTDTALKEHPELFKEYFGTVIPVGDNKFASLNTAVWSGGSFIYVPKGVHVEIPLQAYFRINTENMGQFERTLIIVDEGAYVHYVEGCTAPIYKSDSLHSAVVEIIVKKNARCRYTTIQNWSNNVYNLVTKRAVAYEGATMEWIDGNIGSKVTMKYPAVYLMGEHAKGETLSIAFAGEGQHQDAGSKMVHMAPNTSSNIVSKSVARGGGRTSYRGLVEIGEGAHGSKSNVLCDALLVDTISRSDTYPYVDVREDDVSMGHEATVSKVSDDQLFYLMSRGMTEFEAMAMIVRGFVEPIAKELPMEYALELNRLIELQMEGAVG
>NZ_CP049838.1|WP_171396561.1|2679758_2680940_-|Fe-S-cluster-assembly-protein-SufD
MAEAQNIPVGSTTAGQIAVAAESTVATRMSAPASFDVADFPVPHGREEEWRFTPLERLRGLHDGTAVATGEGVKVAVEAPEGVTVELVDRDDPRLGKAGTPVDRVAAQAYSAFEKAGVVTVPKETVLTEPIRIAVHGEGGVSYGHQVIELGAFAEAVVVIDHTGDAVLAANVDYVLGDGAKLTVVSVQDWDDKAVHVAQHNALVGRDATFKSVVVTFGGDLVRLHPRVAYAGPGAEAELFGLYFTDAGQHQEHRLLVDHNVPHCKSNVVYKGALQGEGAHAVWIGDVLIEAKAEGTDTYEMNRNLVLTDGARVDSVPNLEIETGEIVGAGHASATGRFDDEQLFYLMARGIPADEARRLVVRGFFAELVQQIGVDDIEERLLARIETELEATV
>NZ_CP049838.1|WP_020130534.1|2679441_2679759_-|non-heme-iron-oxygenase-ferredoxin-subunit
MAYVRACGLSELEEDTPTRVELDGTPVSVVRTEGEVFAIHDICSHANVSLSEGEVEDCQIECWLHGSSFDLRTGKPSGLPATRPVPVYPVKIEGDDVLVSLTQES
>NZ_CP049838.1|WP_020130533.1|2678669_2679434_-|Fe-S-cluster-assembly-ATPase-SufC
MATLEIRDLHVTVEADNATKEILKGVDLTVKQGETHAIMGPNGSGKSTLAYSLAGHPKYTITGGTVLLDGEDVLEMSVDERARAGLFLAMQYPVEVPGVSVSNFLRTSATAIRGEAPKLRTWVKEVKEAMERLHMDTSFAERNVNEGFSGGEKKRHEILQLELLRPKVAILDETDSGLDVDALRIVSEGVNRVRETGEVGTLLITHYTRILRYIKPDFVHVFSAGRIVESGGAELADKLENEGYEAYTKGGVSA
>NZ_CP049838.1|WP_171396560.1|2677416_2678673_-|cysteine-desulfurase
MTQLPGLLDTEAIRKDFPILDRQVHDGRKLVYLDNAATSQKPRQVLDALNEYYERYNANVHRGVHVLAEEATALYEGARDKVAAFINAPSRDEVIFTKNASESLNLVANMLGWADEPYRVDSETEIVITEMEHHSNIVPWQLLSQRTGAKLKWFGLTDDGRLDLSNIDEIITEKTKIVSFVLVSNILGTVNPVEAIVRRAQEVGALVLIDASQAAPHMPMDVQALQADFVAFTGHKMCGPTGIGVLWGRQELLEDLPPFLGGGEMIETVSMHSSTYAPAPHKFEAGTPPIAQAVGLGAAIDYLSAIGMDKILAHEHAITEYAVRRLTEVPDLRIIGPATAEDRGAAISFTLGDIHPHDVGQVLDEQGIAVRVGHHCARPVCLRYGIPATTRASFYLYSTPAEIDALVDGLEHVRNFFG
>NZ_CP049838.1|WP_062649697.1|2676930_2677398_-|SUF-system-NifU-family-Fe-S-cluster-assembly-protein
MKLDSMYQEVILDHYKHPHGRGLRDGDAEVHHVNPTCGDEITLRVKYDGTKIEDVSYEGQGCSISQASASVLNDLLVGKDLAEAQKIQETFLELMQSKGRIEPDDAMEEVLEDAIAFAGVSKYPARVKCALLSWMAWKDATAQALGGADAERKTA
>NZ_CP049838.1|WP_020130530.1|2676601_2676934_-|metal-sulfur-cluster-assembly-factor
MSETLEMKPASEEEVREALYDVVDPELGIDVVNLGLIYGIHIDDANIATIDMTLTSAACPLTDVIEDQAKSATDGLVNELRINWVWMPPWGPDKITDDGREQLRALGFNV
>NZ_CP049838.1|WP_171396559.1|2675678_2676518_+|AbfB-domain-containing-protein
MPDNKSRPSQEQPWENGWAPDTSRAPGTRRLWLAGGLAVATIVACVTAIALNDKPVDDKSEAGQGQTLSDDETGGGLISFATPSASGSTTPTGKKSTTASASASPKTSSSPEAQGSSTPHAPASPAASSTTKPSTPKPAATQRSVRSVNYPDRYWHVSGGLVKLDQVGGSESREDSTFTVVKGLADSSCSTFVTADGRYLRHRDFVLRAERNDGSTLFKQDATFCAVPSSYSSGAVMLESVNYPGRFLRHKNFALRLDAYGYGSNHREDFSFNLVDGLA
>NZ_CP049838.1|WP_171396567.1|2686080_2687091_+|COX15/CtaA-family-protein
MGRVPNVTRADAVAAVRNPLAFIAERWTPTRRTVQRAALYPLVMSVVIVVTGGAVRLTGSGLGCPTWPKCTDDSLTATGAMGFHGAIEFGNRMLTYVLCAAVGWAIIAARSEKPYRRSLTRLGWAQFWLVMSNAVLGGIVVLVGLNPYTVAAHFLAATALLAVAAVMWQRAREGDGEPRPLVGKPVQQLVWFLVVASTLLIAVGTVVTGAGPHAGDSSEVERMPLDWETIAKLHAVLAWIVVTLTFALWFILKAVDAPKNPLDRTRDLFLVLLGQGVIGYVQYFTDLPEALVGLHMFGSCLVWIAVLRVLLALRERPETTIDLPGPAAEVTVGTRA
>NZ_CP049838.1|WP_171396568.1|2687146_2687893_-|nucleotidyltransferase
MTSRTESLLDRFLAGLPALDPVALWAHGSLAGGDYQEGRSDLDLIAVLAGPLTPRAVWHLGRLHARLRNEPLAPLLHCTYLTPDRAADPERRHLTWAHSRLFRRTVTPVTRRELHDFGRVLYGKPPGALLPPVPDRALGDFVVRDQRDFWRPAVDKAHLWHQNVWVDLGLLTFARATVTVRDGRLISKREALDELPALGAPSEVVSDIARRRYDEGGAPADEGWPARRAELTRDYLGPVIDGLVTSYR
>NZ_CP049838.1|WP_171396569.1|2687911_2689018_-|amidohydrolase-family-protein
MIETPSLVDQYCHGVLRTELGLGTFEAQLARTEGPPAPGTTLFDTQTGFAVRRWCPPLLGLEPHAPPARYLARRRELGVLEAGRRLLRGSGITTYLVDTGLPGDLTGPSELASAGAAEAREIVRLEPLAEQVADTSGTVESFLANLAESVHGAAANAVAFTSVAGVRHGLALAPEPPGPGEVRGAAGRWLAGRRVGGELSDPVLLRHLLWIAVASGLPLQLHAGLGEPGARVDRTDPVLLTDFVRATAGLGTDLVLLHGYPYHRHAAHLAGVFPHVYADSGAALVRTGARAATILAEILELAPFGKILFSSGAGGLPELHVVGARLFREALARVLGTWVAEGAWSPGDAQRVAGLIAAGNARRVYGLG
>NZ_CP049838.1|WP_171396570.1|2689093_2689450_-|hypothetical-protein
MADTKQVDETADAKQAAKAERKAARLAKRISAFAKRHGGAEGQIAYIGERGARIVLVGEDGGWGDLVAPSVAVAELAVGKAGITVHETFDGEFAAKVKTGPYEWTRMAGIQVGGPKNG
>NZ_CP049838.1|WP_171396571.1|2689548_2690472_-|protoheme-IX-farnesyltransferase
MGEIGTSQSPSRRPFGARVKAFVALTKPRIIELLLITTVPVMFLAQQGVPDLGLVVLTCLGGYLSAGGANALNMYIDRDIDALMDRTSQRPLVTGMVSPRECLAFGITLAVVSTLLFGLTVNWLSAWLALGALLFYVVVYTMILKRRTSQNIVWGGIAGCMPVLIGWSAVTDSVSWAPVVLFLVMFFWTPPHYWPLSMKVKDDYARVGVPMLPVVASNKTVAKQIVLYSWVMVAVSLLLTPLGYTGWFYTSVALVAGGWWLWEAHGLQSRAKAEVTGGKLKEMRLFHWSITYVSLLFVAVAVDPFLR
>NZ_CP049838.1|WP_171396572.1|2690890_2692978_+|transketolase
MSTKPTTTDLEWTELDQRAVDTARVLAADAVQKVGNGHPGTAMSLAPAAYTLFQKVMRHDPADADWVGRDRFVLSAGHSSLTLYTQLYLAGFGLELDDLKSFRTWGSKTPGHPEYGHTTGVETTTGPLGQGVANAVGMAMAARYERGLFDPETPAGESPFDHFVYAIAGDGCLQEGISAEASSLAGHQKLGNLVLLWDDNHISIEGDTETAVSEDTAKRYEAYGWHVQRVAPKPDGDLDPHALYDAIEAAKQVTDKPSFIAMRSIIAWPAPNAQNTEAAHGSALGDDEVAATKRVLGFDPEKSFEVADEVIAHTRGALERGQAARAVWEKSFQQWRDNNPDRAAEFERVAAGELPTGWEEKLPVFEPGKGVATRAASGKVLQALGAVIPELWGGSADLAGSNNTTIDKTSSFLPADNPLPEADPYGRTVHFGIREHSMAAEMNGIALHGNTRIYGGTFLVFSDYMRNAVRLSALMHVPVTYVWTHDSIGLGEDGPTHQPVEHLASLRAIPGLNIVRPADANETTIAWREILKRWTKVFGKGAPHGLVLTRQGVPTYEPDENAAKGGYVLFEASTGTPEVLLIATGSEVHVAVEARERLEADGVPTRVVSMPSVEWFEEQDQGYRDSVLPPSVKARVSVEAGIGLTWHKYVGDAGRIVSLEHFGASADGKVLFQEYGFTAENVADKARESLAAAQR
>NZ_CP049838.1|WP_171396573.1|2693011_2694130_+|transaldolase
MTDALKRLSEEGVAIWLDDLSRKRITSGNLAELIDQQHVVGVTTNPSIFQKAISQGDGYDQQLSDLAARKVTVEEAIRMITTADVRDAADILRPVFDATGGQDGRVSIEVDPRLAHHTKPTVAEAKQLAWLVDRPNTLIKIPATMGGLPAITEVIGLGISVNVTLIFSLERYRQVMDAYLAGLEQAKERGLDLSKIHSVASFFVSRVDTEIDKRLDALGTDEAKAARGKAGLANARLAYQAYEEVFAGERWAALEKAGANKQRPLWASTGVKDPAYKDTLYVDDLVAPNTVNTMPEATLFATEDHGQITGNTVAGTYEQARAEIDAVEKLGISYDDVVQLLEDEGVDKFEASWNDLLKSTEAELQRLAPSEG
>NZ_CP049838.1|WP_171401950.1|2694133_2695657_+|glucose-6-phosphate-dehydrogenase
MSSSNPLRDPADRRLPRIAGPSGLVIFGVTGDLSRKKLMPAVYDLANRGLLPPGFSLVGFARREWEHEDFAQEVHDAVKEHARTPFREEVWQQLVQGMRFVQGTFDDDDAFERLRGTIEELDKAQGTGGNFAFYLSVPPRSFPVVIQQLKKHGLADQKNGSWRRAVIEKPFGHDLASAEELNKVVHEVFGSDQVFRIDHYLGKETVQNIMALRFANTMFEPIWNRSFVDHVQITMAEDIGIGGRAGYYDGIGAARDVIQNHLLQLMALTAMEEPASFDADALAAEKTKVLGAVRLPKDLGRATVRAQYAAGWQGGEKAVGYLEEDGIDPKSKTDTYAAVKLEVDNRRWAGVPFYLRTGKRLGRRVTEIAVVFQRAPHSPFDSTATEELGANAIVIRVQPDEGITVRFGSKVPGTSMEIRDVSMDFAYGESFTESSPEAYERLILDVLLGDSNLFPRTEEVELSWKILDPIEQYWDKNGKPAQYPSGTWGPVEADEMLERDGRSWRRP
>NZ_CP049838.1|WP_171396574.1|2695653_2696787_+|glucose-6-phosphate-dehydrogenase-assembly-protein-OpcA
MKTDLTDTTASKINKALVQGRRAIGTPAVGMVLTLVVVTDEENAYDALKAANDASHEHPSRTLVVIKRVSRSPRGRTQSRLDAEVRLGADAGSGETVILRLYGEVSDHAQSVVLPLLLPDAPVVVWWSVDAPRDPAGDPLGALGQRRVTDSYAAEKPINELRARAESYEPGDTDLAWARITPWRSMLAAALDQVSCEIVSAEVAGEEANPSVELLAMWLADRLHVHVRRAISAGPGLTQVRMETTGGPITLHRSDGAMATLALPGQPDRAVALKRRETSELLAEELRRLDPDDTYASALRFGVDRLGGIQSAAEREAERAEAAGQPTPSLPVRAVPEPAATGPDSASAPPATAPAGHGDADRPTPAQMPPVRKADPQ
>NZ_CP049838.1|WP_171396575.1|2696783_2697566_+|6-phosphogluconolactonase
MSTPQLVVHHDKELMAQAAAARLITKIVDAQASRGQASVVLTGGRNGNGLLAALATAPARDAVDWARLDLWWGDERFVPEGDPERNVTQAREALLDSVPVDPKRVHAMPASDGPYGADVEAAAAAYAEELARAAGPENHGNVPAFDVLMLGVGPDTHVASLFPELPAVRETERTVVGVRGAPKPPPTRVTLTLPAIRAAREVWLLAAGEDKAQAAAIALSGAGEIQAPAAGARGRSRTLWLLDTAAASRLPRSLYPPASA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP049838_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049838_3

2771533-2771665

Orphan

Consensus_repeat	Method
AGGTCCAGCGGCACGGAGGTCCAGCGGCC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP049838_3

>merge|NZ_CP049838|3|2771533-2771665|CRISPRCasFinder
AGGCCCACAGGCCCGGAAGCCCAGAGGTCCAGCGGCACGGAGGTCCAGCGGCACGGAGGTCCAGCGGCCCGGAGGTCCAGCGGCCCGGAAGCCCGGAAGGTCACAGGTCCAGCGGCACGGAGGTCCAGCGGCC

>NZ_CP049838|3|3|2771533-2771665|CRISPRCasFinder
AGGCCCACAGGCCCGGAAGCCCAGAGGTC	CAGCGGCACGGAGGTCCAGCGGCACGG
AGGTCCAGCGGCCCGGAGGTCCAGCGGCC	CGGAAGCCCGGAAGGTCAC
AGGTCCAGCGGCACGGAGGTCCAGCGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049838.1\|WP_171401956.1\|2768798_2769530_-\|uracil-DNA-glycosylase	unknown	unknown	gnl\|CDD\|381681
NZ_CP049838.1\|WP_171396635.1\|2780744_2782481_-\|lytic-murein-transglycosylase	unknown	unknown	gnl\|CDD\|381602
NZ_CP049838.1\|WP_171396622.1\|2763934_2764180_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171396634.1\|2780442_2780577_-\|SPW_0924-family-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171401958.1\|2776882_2779420_+\|ATP-dependent-helicase-HrpB	unknown	unknown	gnl\|CDD\|273901
NZ_CP049838.1\|WP_171396632.1\|2772843_2773782_-\|PAC2-family-protein	unknown	unknown	gnl\|CDD\|378251
NZ_CP049838.1\|WP_171396633.1\|2779409_2780402_-\|DUF3068-domain-containing-protein	unknown	unknown	gnl\|CDD\|371444
NZ_CP049838.1\|WP_171396630.1\|2771681_2772062_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP049838.1\|WP_171396627.1\|2769772_2770213_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|379266
NZ_CP049838.1\|WP_171396625.1\|2766577_2767276_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP049838.1\|WP_171396628.1\|2770400_2771084_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_CP049838.1\|WP_171396624.1\|2764945_2766424_-\|NCS1-family-nucleobase:cation-symporter-1	unknown	unknown	gnl\|CDD\|271404
NZ_CP049838.1\|WP_171396631.1\|2772112_2772733_-\|dephospho-CoA-kinase	unknown	unknown	gnl\|CDD\|179560
NZ_CP049838.1\|WP_171396629.1\|2771258_2771525_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171396626.1\|2767333_2768791_+\|LamG-domain-containing-protein	unknown	unknown	gnl\|CDD\|379155
NZ_CP049838.1\|WP_054242950.1\|2774073_2775582_-\|30S-ribosomal-protein-S1	unknown	unknown	gnl\|CDD\|236126
NZ_CP049838.1\|WP_171396623.1\|2764217_2764931_-\|Asp/Glu/hydantoin-racemase	unknown	unknown	gnl\|CDD\|226611
NZ_CP049838.1\|WP_171401957.1\|2775962_2776784_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NZ_CP049838.1\|WP_171396636.1\|2782836_2783748_+\|DUF4184-family-protein	unknown	unknown	gnl\|CDD\|379379
NZ_CP049838.1\|WP_171396621.1\|2763329_2763713_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP049838.1\|WP_171401956.1\|2768798_2769530_-\|uracil-DNA-glycosylase	gnl\|CDD\|381681	cd10031, UDG-F5_TTUDGB_like, Uracil DNA glycosylase family 5, includes Thermotoga maritima TTUDGB and similar proteins. Uracil DNA glycosylase family 5 includes Thermus thermophilus HB8 TTUDGB (also called UDGb) which is not only a UDG acting on double-stranded uracil-containing DNA, but also a hypoxanthine DNA glycosylase acting on double-stranded hypoxanthine-containing DNA (except for the C/I base pair), as well as a xanthine DNA glycosylase acting on both, double-stranded and single-stranded xanthine-containing DNA. TTUDGB also excises thymine from G:T mismatched DNA, and removes analogs of uracil from DNA, including 5-hydroxymethyluracil (hmU) and 5-fluorouracil (fU). This subfamily also contains Bradyrhizobium diazoefficiens family 5 homolog Blr5068 (UdgB) which has been found to efficiently excise uracil from ssDNA and dsDNA. Uracil-DNA glycosylases (UDGs) initiate repair of uracils in DNA. Similar to family 4 UDGs, members of this family possess four conserved cysteine residues required to coordinate the [4Fe-4S] iron-sulfur cluster. Uracil in DNA can arise as a result of mis-incorporation of dUMP residues by DNA polymerase or via deamination of cytosine. Uracil in DNA mispaired with guanine is one of the major pro-mutagenic events, causing G:C->A:T mutations. Thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other.	1.18713e-117
NZ_CP049838.1\|WP_171396635.1\|2780744_2782481_-\|lytic-murein-transglycosylase	gnl\|CDD\|381602	cd13399, Slt35-like, Slt35-like lytic transglycosylase. Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).	5.74324e-29
NZ_CP049838.1\|WP_171396630.1\|2771681_2772062_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	6.16613e-09
NZ_CP049838.1\|WP_171401958.1\|2776882_2779420_+\|ATP-dependent-helicase-HrpB	gnl\|CDD\|273901	TIGR01970, ATP-dependent_RNA_helicase_HrpB, ATP-dependent helicase HrpB. This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity].	0
NZ_CP049838.1\|WP_171396632.1\|2772843_2773782_-\|PAC2-family-protein	gnl\|CDD\|378251	pfam09754, PAC2, PAC2 family. This PAC2 (Proteasome assembly chaperone) family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 247 and 307 amino acids in length. These proteins function as a chaperone for the 26S proteasome. The 26S proteasome mediates ubiquitin-dependent proteolysis in eukaryotic cells. A number of studies including very recent ones have revealed that assembly of its 20S catalytic core particle is an ordered process that involves several conserved proteasome assembly chaperones (PACs). Two heterodimeric chaperones, PAC1-PAC2 and PAC3-PAC4, promote the assembly of rings composed of seven alpha subunits.	8.87767e-40
NZ_CP049838.1\|WP_171396633.1\|2779409_2780402_-\|DUF3068-domain-containing-protein	gnl\|CDD\|371444	pfam11271, DUF3068, Protein of unknown function (DUF3068). Some members in this family of proteins with unknown function are annotated as membrane proteins however this cannot be confirmed.	7.46411e-95
NZ_CP049838.1\|WP_171396627.1\|2769772_2770213_-\|DoxX-family-protein	gnl\|CDD\|379266	pfam13564, DoxX_2, DoxX-like family. This family of uncharacterized proteins are related to DoxX pfam07681.	6.90242e-10
NZ_CP049838.1\|WP_171396625.1\|2766577_2767276_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	2.27145e-49
NZ_CP049838.1\|WP_171396628.1\|2770400_2771084_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.71635e-15
NZ_CP049838.1\|WP_171396624.1\|2764945_2766424_-\|NCS1-family-nucleobase:cation-symporter-1	gnl\|CDD\|271404	cd11555, SLC-NCS1sbd_u1, uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).	0
NZ_CP049838.1\|WP_171396626.1\|2767333_2768791_+\|LamG-domain-containing-protein	gnl\|CDD\|379155	pfam13385, Laminin_G_3, Concanavalin A-like lectin/glucanases superfamily. This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.	7.46534e-30
NZ_CP049838.1\|WP_054242950.1\|2774073_2775582_-\|30S-ribosomal-protein-S1	gnl\|CDD\|236126	PRK07899, rpsA, 30S ribosomal protein S1; Reviewed.	0
NZ_CP049838.1\|WP_171396623.1\|2764217_2764931_-\|Asp/Glu/hydantoin-racemase	gnl\|CDD\|226611	COG4126, COG4126, Hydantoin racemase [Amino acid transport and metabolism].	9.49964e-53
NZ_CP049838.1\|WP_171401957.1\|2775962_2776784_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	4.7742e-23
NZ_CP049838.1\|WP_171396636.1\|2782836_2783748_+\|DUF4184-family-protein	gnl\|CDD\|379379	pfam13803, DUF4184, Domain of unknown function (DUF4184). This domain of unknown function contains several highly conserved histidines.	3.57546e-47
NZ_CP049838.1\|WP_171396631.1\|2772112_2772733_-\|dephospho-CoA-kinase	gnl\|CDD\|179560	PRK03333, coaE, dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional.	9.83246e-91

>NZ_CP049838.1|WP_171396629.1|2771258_2771525_+|hypothetical-protein
MRTGSEPVTARSALRMRLWLTLWGLAWAIFGTAAFALVGRPGWAAACGVLWLVITVDLTMILRHRRQGPHYQPGRDIPPYRPPEHRHP
>NZ_CP049838.1|WP_171396628.1|2770400_2771084_-|class-I-SAM-dependent-methyltransferase
MRDGYKGTGPGAITPDGCAVELYSRLPVGNEPEVIAEAVPAGAHILELGSGVGRVTHALLERGFTVTAVDESAEMLERVRGARTICSPIEDLALAETFDVVMLASFLVHNGDVELRRRMLRACARHVAKGGCVLIQREGEDYHSNVPRERVDPSGFTIRIVSDEPVGDGVHSVRAEYDFPDAVWTQTFRSRPLTKDQFEEALAEAGLRVERYLTEDRMWVRAVPVTE
>NZ_CP049838.1|WP_171396627.1|2769772_2770213_-|DoxX-family-protein
MSETTASLAATTSAAASTRGRRARIALRGLQVLLALFYGIVSALPKLIAHPSAADAFDEMGWGSGGMYTIGALELAGAVALLIPVLQSVAAVALGALMVGAFVVQVVVFDGQNAATPLILLVPLALIAWKRRESNVELLRLARRGA
>NZ_CP049838.1|WP_171401956.1|2768798_2769530_-|uracil-DNA-glycosylase
MVVLDRRVGGCRACPRLVDWREEVARTKRAAFADWTYWGRPVPGFGPSDARLLIVGLAPAAHGGNRTGRMFTGDRSGDVLYQALYDVGLASQPTAVSVDDGLELYGVRITSPVHCAPPANKPTPGERDTCRPWLVQELRLLRPTLRAVVVLGAFGWQAALPAFAEAGWTVPRPRPAFGHGTRVQLDGPDRPGGQGGPGGPGGADGLDVFGCFHVSQRNTFTGRLTPEMLRDVLRTAAGAAGLR
>NZ_CP049838.1|WP_171396626.1|2767333_2768791_+|LamG-domain-containing-protein
MVSRRRLLSGAALVGAGAVTGVLGAAGSAAADASLDTPFTPVAAPHLAQAEQMVRYQRLLAAGYLPTGLTGHWPLDGSGADRSGRDHPVSPGTGASWTTLRAGGELTLDAAYAATASVLDTTTPFTVSAWVRLADDATLTTMYTAVSQDGTGCSRFLLQYDDTAGAWAFKVRAEDQSVKISALATTAPVPGKWTHLTGVWDGTRVHLYVNGVPEGTADATLSWAATQGFNIGRARWNGAYVNHFKGSVDDVRAYGRALSADEISLISGRTARLNNVYLIGSPSTVTWGTPDDLSSWIARARCSSFVTWVLKHTYGWATDAYFTQYFEDRVPEAADYRQAFADGTAGPRFQQIRKVADLRPGDLIAVDYSGQVEGNTGHIVMVREVKGVFSGVADFTGETQYAVEVVDCTAEPHGVYALTNYPKYPDTRMVSLAAEEQFEGVGIGHMMFYASSTTGEFSRYRWSVNTARDKAYPVASRPVTAARIV
>NZ_CP049838.1|WP_171396625.1|2766577_2767276_+|GntR-family-transcriptional-regulator
MTKIEPLGAVRERVLGSLRQEIIAGRLRPGDRLVERELADRFGVSRVPVREAIRALVAEGFVLFETPRRTVVRPLSPTDVKELFELREALEVYAAGLAAARATPEDLAELRELLASAARATDAGDAEAITDINTHFHDRLLAMAGNTLLISVMEPVAGRLQWLTRRNEEWPQLLTEHQDLYDAIASGDPARARAHALDHVQANYRSTVRHLFGETNSPEAPPLPDHAPPRIP
>NZ_CP049838.1|WP_171396624.1|2764945_2766424_-|NCS1-family-nucleobase:cation-symporter-1
MSLADSAEATGAPAFVPDPRLTNEDLAPAEKRNWKVFDLFAMWMSDVHNLGNYTFAAGLLVLGMNVWQIFTSLLVGFVLIYVGMNWMGRIGQRHGVPFPVVSRISFGVWGANIPALIRAVIAIMWYGIQTYLASVAVNVMLLAAWPGLESWTHSSFLGLDALGWLSFVSLWLVQAMIISQGMESVRKFQDFCGPAIWLVMIALAVWVLSKAGWTISLTSTPHPVSVGEQWRQWFGAIGLILATYGTLMLNFCDFSRFAPDYRTVRRGNFWGLPLNSTAFVVVSVIVTAGSLEVFGEAITDPAELVAKVGNTWVLVLGALTFAVATMGVNIVANFVSPAYDLANVWPQKITFKVGGMISTVAALVVTPWNLFSNPTVVNYFLGGLGAFLGPLFGVIMVDYYWVKRGRVDVNELFDATPGSRYYYRKGVNPKALWAFLPSAAVAAVLALVKTFSDVAPYSWFIGTALGAGLYVLLCRSERTAGSVVAAEKPVEV
>NZ_CP049838.1|WP_171396623.1|2764217_2764931_-|Asp/Glu/hydantoin-racemase
MRIVVTNCNTTQEMTEEIVRGARAAAGPGTTVTGLTPGWGPESAEGWLDSFLSAAAVMDALRTYDGAPYDAVVMAGFGEHGREGVRELVDVPVVDITEAAAHLACLLGRRYGVVTTLERSCGQIEDSLELAGVGRNCAAVVGTGLGVLDLGDRDRTEAAFLAAAEQIRAAGAEVLVLGCAGMTGLERMVGDKLGLPVVDGVGAAVKLAEGLVGLGLTTSRAGSFAKPVPKRRVWGAE
>NZ_CP049838.1|WP_171396622.1|2763934_2764180_+|hypothetical-protein
MVRYREDGRQYVSLAGLRMRGWTGPLVLRLLGPPDRLGIDPRARAAPQLRLYRVERVEAAERSEEFLTQCAPRIRGPEESP
>NZ_CP049838.1|WP_171396621.1|2763329_2763713_-|hypothetical-protein
MSRTVHHVRLRHRVRPDDRPSQRWGWSTGHRLGELRYSARELARARRERRRPVPVPLVCAFRSYTFPRSLNARIDGPYESRARAALSVFRSTARNELRAAPSGALLSAAEDLDHPPTRHRHRNVWDC
>NZ_CP049838.1|WP_171396630.1|2771681_2772062_-|tetratricopeptide-repeat-protein
MPDTSGSTGRTPETHVIDFRAAEHLLAARDPRGAVKLLDGVIAAHPENTAARLLRARAFFAAAQLRPAELEFTIVLEREPDNAFAHFALGRTYERQGRGDQAKRHFRLAAALDPNPQYLKAARFES
>NZ_CP049838.1|WP_171396631.1|2772112_2772733_-|dephospho-CoA-kinase
MLKVGLTGGIGAGKSEVSRLLVECGAVLIDADRIAREVVAPGTPGLAAVVDAFGADVLAPDGSLDRPRLGSVVFADPAKLAVLNSIVHPLVGARSRELEAAAPEDAVVVHDVPLLTENALGPLYDVVVVVDAAPETQLDRLVRLRGMTEEDARARMAAQATRDKRRDIADIVIDNDVPLAELHRRVKDVWADLTRRAHAPHGTSPE
>NZ_CP049838.1|WP_171396632.1|2772843_2773782_-|PAC2-family-protein
MLDPQGLYAWEPKGLAVVDMALAQESAGLVMLYHFDGYIDAGETGDQIVDRLLDSLPHQVVARFDHDRLVDYRARRPLLTFKRDRWTEYEEPTIEVRLVQDTTGAPFLLLSGPEPDVEWERFAVAVKQIVERLGVRLSVNFHGIPMGVPHTRPVGLTPHGNRTDLMPGHRSPFDEAQVPGSAEALVEYRLMEAGHDILGVAAHVPHYIARSAYPDAALTVLEAITAATGLVLPGIAHALRTDAHRTQTEIDRQIQEGDEELTSLVQGLEHQYDAAAGAETRGNMLAEPVDIPSADEIGQEFERFLAEREGEG
>NZ_CP049838.1|WP_054242950.1|2774073_2775582_-|30S-ribosomal-protein-S1
MTSSTETTSTTPQVAVNDIGNEEAFLAAIDETIKYFNDGDIVDGVIVKVDRDEVLLDIGYKTEGVIPSRELSIKHDVDPNEVVAVGDEIEALVLQKEDKEGRLILSKKRAQYERAWGTIEKIKEEDGIVTGTVIEVVKGGLILDIGLRGFLPASLVEMRRVRDLQPYVGKELEAKIIELDKNRNNVVLSRRAWLEQTQSEVRQTFLTTLQKGQVRSGVVSSIVNFGAFVDLGGVDGLVHVSELSWKHIDHPSEVVEVGQEVTVEVLDVDMDRERVSLSLKATQEDPWQQFARTHQIGQVVPGKVTKLVPFGAFVRVDEGIEGLVHISELAERHVEIPEQVVQVNDEIFVKVIDIDLERRRISLSLKQANESFGADPASVEFDPTLYGMAASYDDQGNYIYPEGFDPETNDWLEGFESQREVWENQYAEAQTRFEQHQAQVIKSREADEKAAAEGGDTAGAAPAASGGSGGGSYSSEGADTSGALASDEALAALREKLAGGQS
>NZ_CP049838.1|WP_171401957.1|2775962_2776784_+|class-I-SAM-dependent-methyltransferase
MQEPESSEPAFEPEATRRDADVTESSRANRGWWDRNADEYQIEHGTFLGDDRFVWGPEGLDEVEAELLGPPEELKGKSVLEIGAGAAQCARWLTAQGARPVALDLSHRQLQHALRIGGSFPLVCADAGALPFADASFDLACSAYGALPFVADPVLVLKEVRRVLRPGGRFVFSVTHPIRWAFPDEPGPEGLTVSSSYFDRTPYVEQDDQGRAVYVEHHRTLGDRVRDIVAGGFRLVDLVEPEWPAWNSSEWGGWSPLRGNLIPGTAVFVCERD
>NZ_CP049838.1|WP_171401958.1|2776882_2779420_+|ATP-dependent-helicase-HrpB
MPRYDALDALPVRSALPALNDALDGHGTAVLAAPPGTGKTTLVPLALAGLLGEGPARRVLVAEPRRIAARAAARRMAWLLGERPGESVGHTVRGERVVGRHTRVEVVTTGVLLQRLQRDQELSGVDVVVLDECHERHLDADTSAAFLWDVRETLRPELRLVAASATTDTAGWSRLLGGAPVVEARGSVFGVEVVWAPPARPVRPPHGMRVDPALLAHVASVVRRALAERSGDVLCFLPGVGEIARVAGLLGEPAGVDVLQVHGRAPAAVQDAVLAPGQRRRVVLATSVAESSLTVPGVRVVVDSGLAREPRVDHARGLSALATVRASQAAGRQRAGRAGREAPGAVYRCWAEAEDARLPSFPAPEIRVADLTAFALQAACWGDPDASGLALLDPPPGGAMAAARSLLTAIGAVDSSGRATARGLRLARLGLHPRLGRALLDGAASVGVERAVEVVALLSEEAPREYGDDLAAALRSARRGGDAYGARWRAEVRRLRAVVEDSAPTGPAGAGGKGNRSGDAAGSDARAGLVVALAFPERLARADGGSYLMVSGTRAEVREGTDLRGASWLAVAVADRPVGKGHARVQLAAVVDEEVARFAAGALLGEGDEVHWADGDVVARRVERLGAVELAVRPLRDADAGLVRGALVEGLEKDGLRLLRWSPEADVLRQRLAFLRWHLGEPWPDVSDASLHARVDEWLEPELSRARRRSDLGRIAAGEALGRLLPWASGEAARLEELAPERIAVPSGSRIRIDYADPERPVLAVKLQEMFGLQESPRVAGVPLLVHLLSPAGRPAAVTADLASFWKDGYKGVRAELRGRYPKHPWPEDPAGAEPTRFTNARLRR
>NZ_CP049838.1|WP_171396633.1|2779409_2780402_-|DUF3068-domain-containing-protein
MRRKASLILLALAVFFAALSPLLRWYAFPHLAKIPANEYQTMVLEAKNATLLDYDGLVARTVPKVTIVQTLKGDVEASEKIEKTAGRDVVVWDGLSYVQGPDGKMVSKVPERYIFDAHTQEPVHATGEMVDGDPVRREGIEFKWPFLTEKRDYEYFDAQTRTTAPIHYKGTQNFRGLEVYYFEQTVPWTKVAMPRTMPVKGITPQDIAKTGTTRWYTTVRKFWVEPVTGAPVYGEEIHKEELRGGTLLGGRAKVTAFAGHVKMREDYIEHTVSVIKSNRTLVLLLTAYLPWGFLLLGALLMSLSLYLEARARRPDEPTAAEPAAPQPVTA
>NZ_CP049838.1|WP_171396634.1|2780442_2780577_-|SPW_0924-family-protein
MRALIAAATGLAVALALVLTLAALGTPAGKTSPKPLLTTVPAHP
>NZ_CP049838.1|WP_171396635.1|2780744_2782481_-|lytic-murein-transglycosylase
MSAHFGTRLRKGAVNTTVAALAVAALAASQAPDVTADGHGRQTAADTPSAADDGSGIGDSATGNSPYYTDLPPLNSPLPAPSESSSTTPAATGTTEAGIPATVLDAYKKAEAELAQSKPGCNLPWQLLAAIGKVESGQARGGNVTADGTTVSPILGPVLNGVGFANISDTDNGAYDGDSTYDRAVGPMQFIPSTWAWAGRDGNADGKKDPNNIYDAALAAGHYLCRYDWDMSATSGMRSAILSYNNSTDYLNTVLSWLEYYRKGTHEIADGTGTVPDNRSDDGTGSTPASPSTPSTPSTPSTPSTPSKPSKPSTPNTPSTPSTPTPTPTPTPTETVGHLEDAGTASLTAMAGDTFTERISTRAETAAGKAVAKVRIRFTIVGDTDATFTGGESVATISTGANGVALAPALVAGEKTGGFTVRATVLGRTLSALDYKATVTARAADTLARTSATALTCTAGGEFADQVEVKATYKGAVADKVAATATLIKSADDATTNDKGPYFKDAAGNPVRTLDLQTDANGLLELPKLYADDTAGTYLLRITTTGGATLTVELTVTAAETSTPSPTPSESESTTTGS
>NZ_CP049838.1|WP_171396636.1|2782836_2783748_+|DUF4184-family-protein
MPFTLSHAAAVLPAVRADGTGRGSLVPGALVAGSLAPDMTYYAASVVSGAMEFGDVTHSLPGVFTVDVLVAWVLVGLWLLVREPLVALLPRSRQGRTAALTRCGVPRARVRPSTALWWYVSAALGALTHVVWDAFTHLDRWGMRLFPVLGEDIAGSPLYWYLQYGGSAVAAVVLAAFVTHALRRAPAGEPVGVAVLSVRDRWWAGAVIGGCALVAAVRRAMRWWEYWGAREAKPWELVPTLCFGAGAGLVLGVLLYAVGVRLWRPARPAHPAHPAALDARAGQPEAGAGADGVSVRRSRPGVR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP049838_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049838_4

3479356-3479469

Orphan

Consensus_repeat	Method
GCCGCCGTCCGAGTTGCTGTAGCTGCTCTTGCGCCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049838_4

>merge|NZ_CP049838|4|3479356-3479469|CRISPRCasFinder
GCCGCCGTCCGAGTTGCTGTAGCTGCTCTTGCGCCAGGCGGCGGCACTGAGGAGGTCGTCGGAGACCTCGAGGCACTGGCCGCCATCCGAGTTGCTGTAGCTGCTCTTGCGCCA

>NZ_CP049838|4|4|3479356-3479469|CRISPRCasFinder
GCCGCCGTCCGAGTTGCTGTAGCTGCTCTTGCGCCA	GGCGGCGGCACTGAGGAGGTCGTCGGAGACCTCGAGGCACTG
GCCGCCATCCGAGTTGCTGTAGCTGCTCTTGCGCCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049838.1\|WP_171402003.1\|3479480_3480323_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262
NZ_CP049838.1\|WP_028806487.1\|3486492_3486912_+\|transcriptional-repressor	unknown	unknown	gnl\|CDD\|133478
NZ_CP049838.1\|WP_020127702.1\|3488457_3489309_-\|isoprenyl-transferase	unknown	unknown	gnl\|CDD\|237826
NZ_CP049838.1\|WP_171397135.1\|3476305_3476902_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380062
NZ_CP049838.1\|WP_171397137.1\|3478126_3479239_+\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|197338
NZ_CP049838.1\|WP_171397144.1\|3485530_3486433_+\|metal-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224033
NZ_CP049838.1\|WP_171397139.1\|3480488_3480878_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171397130.1\|3471065_3472511_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP049838.1\|WP_171397132.1\|3473609_3475040_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP049838.1\|WP_171397140.1\|3481122_3482094_+\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238861
NZ_CP049838.1\|WP_171397128.1\|3467450_3469718_+\|CDP-alcohol-phosphatidyltransferase	unknown	unknown	gnl\|CDD\|293739
NZ_CP049838.1\|WP_171397145.1\|3487020_3488376_-\|histidine-type-phosphatase	unknown	unknown	gnl\|CDD\|366031
NZ_CP049838.1\|WP_171397134.1\|3475403_3476306_-\|UTP--glucose-1-phosphate-uridylyltransferase	unknown	unknown	gnl\|CDD\|133021
NZ_CP049838.1\|WP_171397143.1\|3484709_3485531_+\|metal-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224046
NZ_CP049838.1\|WP_171397141.1\|3482176_3483559_-\|glycine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235240
NZ_CP049838.1\|WP_171397142.1\|3483732_3484692_+\|zinc-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|376518
NZ_CP049838.1\|WP_171397129.1\|3469737_3470892_-\|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl\|CDD\|129820
NZ_CP049838.1\|WP_171397136.1\|3476927_3477938_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381302
NZ_CP049838.1\|WP_171397133.1\|3475154_3475373_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171397131.1\|3472500_3473508_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|375319

Protein	Function_ID	Function_description	E-value
NZ_CP049838.1\|WP_171402003.1\|3479480_3480323_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	1.48591e-05
NZ_CP049838.1\|WP_028806487.1\|3486492_3486912_+\|transcriptional-repressor	gnl\|CDD\|133478	cd07153, Fur_like, Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators. Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.	8.05588e-43
NZ_CP049838.1\|WP_020127702.1\|3488457_3489309_-\|isoprenyl-transferase	gnl\|CDD\|237826	PRK14829, PRK14829, undecaprenyl pyrophosphate synthase; Provisional.	2.42623e-134
NZ_CP049838.1\|WP_171397135.1\|3476305_3476902_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|380062	pfam17935, TetR_C_27, Tetracyclin repressor-like, C-terminal domain. This is the C-terminal domain present in putative TetR transcriptional regulators.	9.93497e-40
NZ_CP049838.1\|WP_171397137.1\|3478126_3479239_+\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|197338	cd10283, MnuA_DNase1-like, Mycoplasma pulmonis MnuA nuclease-like. This subfamily includes Mycoplasma pulmonis MnuA, a membrane-associated nuclease related to Deoxyribonuclease 1 (DNase1 or DNase I, EC 3.1.21.1). The in vivo role of MnuA is as yet undetermined. This subfamily belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.	1.82697e-11
NZ_CP049838.1\|WP_171397144.1\|3485530_3486433_+\|metal-ABC-transporter-permease	gnl\|CDD\|224033	COG1108, ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism].	3.98054e-60
NZ_CP049838.1\|WP_171397145.1\|3487020_3488376_-\|histidine-type-phosphatase	gnl\|CDD\|366031	pfam00328, His_Phos_2, Histidine phosphatase superfamily (branch 2). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches.The smaller branch 2 contains predominantly eukaryotic proteins. The catalytic functions in members include phytase, glucose-1-phosphatase and multiple inositol polyphosphate phosphatase. The in vivo roles of the mammalian acid phosphatases in branch 2 are not fully understood, although activity against lysophosphatidic acid and tyrosine-phosphorylated proteins has been demonstrated.	5.03367e-15
NZ_CP049838.1\|WP_171397130.1\|3471065_3472511_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	3.81577e-78
NZ_CP049838.1\|WP_171397132.1\|3473609_3475040_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	8.2661e-47
NZ_CP049838.1\|WP_171397140.1\|3481122_3482094_+\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238861	cd01823, SEST_like, SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles two of the three components of typical Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxylic acid.	2.73487e-57
NZ_CP049838.1\|WP_171397128.1\|3467450_3469718_+\|CDP-alcohol-phosphatidyltransferase	gnl\|CDD\|293739	cd16015, LTA_synthase, Lipoteichoic acid synthase like. Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.	8.09186e-14
NZ_CP049838.1\|WP_171397134.1\|3475403_3476306_-\|UTP--glucose-1-phosphate-uridylyltransferase	gnl\|CDD\|133021	cd02541, UGPase_prokaryotic, Prokaryotic UGPase catalyses the synthesis of UDP-glucose. Prokaryotic UDP-Glucose Pyrophosphorylase (UGPase) catalyzes a reversible production of UDP-Glucose and pyrophosphate (PPi) from glucose-1-phosphate and UTP. UDP-glucose plays pivotal roles in galactose utilization, in glycogen synthesis, and in the synthesis of the carbohydrate moieties of glycolipids , glycoproteins , and proteoglycans. UGPase is found in both prokaryotes and eukaryotes, although prokaryotic and eukaryotic forms of UGPase catalyze the same reaction, they share low sequence similarity.	4.17342e-122
NZ_CP049838.1\|WP_171397143.1\|3484709_3485531_+\|metal-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224046	COG1121, ZnuC, ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism].	9.22165e-77
NZ_CP049838.1\|WP_171397141.1\|3482176_3483559_-\|glycine--tRNA-ligase	gnl\|CDD\|235240	PRK04173, PRK04173, glycyl-tRNA synthetase; Provisional.	0
NZ_CP049838.1\|WP_171397142.1\|3483732_3484692_+\|zinc-ABC-transporter-substrate-binding-protein	gnl\|CDD\|376518	pfam01297, ZnuA, Zinc-uptake complex component A periplasmic. ZnuA includes periplasmic solute binding proteins such as TroA that interacts with an ATP-binding cassette transport system in Treponema pallidum. ZnuA is part of the bacterial zinc-uptake complex ZnuABC, whose components are the following families, ZinT, pfam09223, pfam00950, pfam00005, all of which are regulated by the transcription-regulator family FUR, pfam01475. ZinT acts as a Zn2+-buffering protein that delivers Zn2+ to ZnuA (TroA), a high-affinity zinc-uptake protein. In Gram-negative bacteria the ZnuABC transporter system ensures an adequate import of zinc in Zn2+-poor environments, such as those encountered by pathogens within the infected host.	2.42634e-94
NZ_CP049838.1\|WP_171397129.1\|3469737_3470892_-\|tRNA-dihydrouridine-synthase-DusB	gnl\|CDD\|129820	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family. This model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). This branch includes NifR3 itself, from Rhodobacter capsulatus. It excludes a broadly distributed but more sparsely populated subfamily that contains sll0926 from Synechocystis PCC6803, HI0634 from Haemophilus influenzae, and BB0225 from Borrelia burgdorferi. It also excludes a shorter and more distant archaeal subfamily.The function of nifR3, a member of this family, is unknown, but it is found in an operon with nitrogen-sensing two component regulators in Rhodobacter capsulatus.Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase. [Unknown function, General].	5.00594e-130
NZ_CP049838.1\|WP_171397136.1\|3476927_3477938_-\|aldo/keto-reductase	gnl\|CDD\|381302	cd19076, AKR_AKR13A_13D, AKR13A and AKR13D families of aldo-keto reductase (AKR). Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.	7.87251e-144
NZ_CP049838.1\|WP_171397131.1\|3472500_3473508_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	4.84375e-42

>NZ_CP049838.1|WP_171397137.1|3478126_3479239_+|endonuclease/exonuclease/phosphatase-family-protein
MSIRIATFNMENLFRRPTAFRIEDPVQRKEILDDFATLVALLDRPLYTDDDKTKIADLIKKHRAYDVDPTDPPPIFVNQARPGKDSGLFKTTGSGKSTRVEVTAKGRFAWAGWAELGQDDFELDVVRNTGRVVSEVDADVLLTVEVEDRLTLERFNTQVLAGALGRRPYPYALLIDGNDPRGIDIGILSRHPITSVRSHLFETDPERPNRRLFSRDCPEFEIQLNGTPLVILGNHLKSKFQDDPELRLAQAKRVAEIYRDALERTPHVIVGGDLNDDPDSETAAALGATGLRDVMSHRSYSGLPGTHGDCKSERNKLDYLLLSPELWQEVQHVGLETRGIFANGIKSFDTVTSKADEASDHASLYVDVDL
>NZ_CP049838.1|WP_171397136.1|3476927_3477938_-|aldo/keto-reductase
MTMRTRSLGTTGPQVSALGLGCMGMSALYGDADRTEGIATIHAALEAGVTLLDTGDFYGMGHNELLIGEALRSAPAARREQAQVSVKFGALRDPDGGWSGYDGRPQAVKNFAAYSLQRLGVDHIDVYRIARLDPDVPIEETVGAIAELVEKGYVRHIGLSEVGAETIRKAAATAPIADLQIEYALISRGIERSILPVTRELGISITAYGVLSRGLISGHFTADRKLAANDFRLYSPRFQGDNLQHNLNLVEALRKIAEQKGVSVAQIAIAWVLAQGEDIVPLIGARTRERLAESLGALDVVLEAADLAAIEDAVPADAAAGDRYSAAAMAHLDSER
>NZ_CP049838.1|WP_171397135.1|3476305_3476902_-|TetR-family-transcriptional-regulator
MSPTTETLTAERILEATEEVLRRHGPAKATVVDVARALGVSHGSVYRHFRTKAALREAVTKRWLDRMSETLSVITADETRTPETRLRDWLAALFAAKRRKAGEDPELFATYMVLAGESGEAVGEHLADLTGQLTRIIEAGVASGDFATPHPRISAVAVFQATGRFHDPGYQRLWERPEAQKDFAALMDLLLRGLRGPA
>NZ_CP049838.1|WP_171397134.1|3475403_3476306_-|UTP--glucose-1-phosphate-uridylyltransferase
MSPTIRRAVIPAAGLGSRLLPLTKAIPKEMLPVGDKPVIEHTVRELVDSGITDITIVVSGGKSLIQDHFRPNPALVEQLRADGKTAYADAVEEVAELARKGHITYLDQHGPYGNGTPVLNAARSFGDEPVLVLWPDDVFVAETPRAQQLIRAYEQTGCPVLALLPMDPADSQRYGVPVVKEDLGDGTLRITGLVEKPDPARAPSSYAAIGGYVITPGIIDELREQTRRWYEHRTGEIYLTDAINAYARGRAVYGQVIQGRWYDTGNPADYLVAQLAHALAHPEYGPVLRGLVSGLDARGD
>NZ_CP049838.1|WP_171397133.1|3475154_3475373_+|hypothetical-protein
MLEINTSKVSRWDQHGREHVVRVRRAGVQRTIRCDTCGWRKGAQFLPWLKAEEHLAEAHQATVDPAEGREPR
>NZ_CP049838.1|WP_171397132.1|3473609_3475040_+|MFS-transporter
MTETITTKAAARTVAAPRALGSLGLFTVLLGAALPLIDFFIVNVALPTMGRDLAASESVLELVVAGYGLAYAVLLVLGGRLGDLFGRRRLFLGGMAAFGLTSLACGLAPDAWSLVAARVAQGASAAAMVPQVLATIQSSTEGPRRAKAMSLYGATAGLAMVAGQILGGVLVAADLAGSGWRSVFLVNVPVVVVGLVLAVRTVPETRSQHPEPADGPGTVLLAAALLTLLAPLTEGRAAGWPLWTWLSLAAFPLVTGAFLAVERRADRQGRTPLVPPSLFALTTLRRGLTIMVPFAIGFSGFMFVIAVALQSGAGLGPVPAGLALAPMALAFFLVSLAGPRLVARFGARVVTAGSVVQGVGVVLILLAVRADWPDVGFVALLPGAAVAGAGQALQLPVVMRIVMSEVPPARAGVGSGVMVTTQQASLALGVATLGTLFLSLVPGMGMRDALVTTLVVQLGGVVVTGLLSLRLPRKVG
>NZ_CP049838.1|WP_171397131.1|3472500_3473508_-|helix-turn-helix-domain-containing-protein
MTTMAQEARARETQAMRRAQGTREAQEARATEEARELQRARESRGAGGSEIRRHELAAFLRSRRERITPEQVGLPRGARRRTPGLRREEVAHLSAVGVTWYTWLEQSRDIQVSVQVLDALARTLLLDPSERAHLFQLAAATDPTPASSCAGVTDAVREVLDQLDPLPACVQNSRYDILAYNRTYAHLLCDLDAIPPEDRNCMVLIHTHPQWRESVVHLDETMRLMAAKLRASMAGHLTEPAWKMLVKRLQSESPEFRENWERYEVVATRSKTKQFRNPHVGLLDLTHTDLWLSPELGARLVTYAPADEVSRERLEKLYAFARVPSAETAESGVRR
>NZ_CP049838.1|WP_171397130.1|3471065_3472511_+|MFS-transporter
MPELSPRRRLLVLAICCMSLLIVSLDVTVLNVALPAMQSDLHASTAGLQWTIDAYTLVLAVLLMLAGSTADRIGRKKVFMAGLVVFTIGSLLCSLAPNLELLVAARMVQAVGGSMLNPVAMSIITNTFTDPRERARAIGVWGAVVGISMAAGPLLGGLLVESVGWRSIFWLNLPIGLVALLATLRYVPESRAPKARRPDPVGQLLVIALFGPLTYAIIEAPEAGAATSVPFAAVALAALIGLLWYEPRRDDPLVDLRFFRSVPFSGATVVAVGAFAALGGFLFLSTLYLQNVRGLDALHAGLWMLPMAVPMFLCAPLSGRLVGSRGPRLPLLISGAAITTSGLLFAVFEAETSDVTLFLGYVLFGVGFGFVNAPITNTAVSGMPRGQAGVAAAVASTSRQLGQTLGVAVIGAVLAAGVSTSAYRDTFVSAAVPGWWILTGCGVVVLVLGAVTTGSWARRTAERTARRLESPEVREAASLSA
>NZ_CP049838.1|WP_171397129.1|3469737_3470892_-|tRNA-dihydrouridine-synthase-DusB
MPTTAPTKNATLRIGPHTVTPPVVLAPMAGITNAPFRTLCREFSGGKGLFVSEMITTRALVERNEKTMQLIHFDATEKPRSIQLYGVDPATVGKAVRMIAEEGLADHIDLNFGCPVPKVTRKGGGSALPFKRHLLRAILREAVSGAGDLPVTMKMRKGIDDDHITYLDAGRIAVEEGVTAIALHGRTAAQHYGGTADWEAIARLKEHVPEIPVLGNGDIWSAEDALRMVRETGCDGVVVGRGCLGRPWLFADLVAAFEGRTEDIARPSLREVADIMVRHATLLGEWIGDEPRGVIDFRKHVAWYLKGFAVGSEMRKRLAITSSLAELRAGLDELDLDQPWPTGADGPRGRTSGNNRVVLPDGWLKDPYDCSGISEDAELDTSGG
>NZ_CP049838.1|WP_171397128.1|3467450_3469718_+|CDP-alcohol-phosphatidyltransferase
MPVTTRSSQPPTPQDPEDNTTEAVEPTESEDPAQTGEPAPPSAPAKAGDPAKTGELAPPGDPAKTGDPAETGDPAKAGDPAETGEPAPPGDPAETGEPAPPGEPAPPGDPAKAGEPAETGDPAKAGEPAETGEPAPPGDPADTGEPAKAEASAAASEGPSGAPSGVTSEDRSGVTSEDPPGVTSGDASSESAPRGLRARVAHWRAWRTRHPRAAQVLWWTVTVLSLVLVLGALVLPNRLVALQVNRFTRLPGEAILGAALLLALPRRPRVVVAATGGVFLGALTVLNLLDMGFVEYLGRDFDLVLDWGLLDDAQSYVADSMGRATAVGAAVGLVLLIVLLFAGMAMATVRISNLMVRNTRVATRATLIAATVWVTCSVVGLQNAGVPVASYRTANALANEARQVRDTLRDEAAFGKVARSDTFGATPAAQLVPDLRGKDVIFTFIESYGRSAIEDPGMAPGVDETLETGTAALTKAGFSAKSGWLTSATYGGSSWLGHSTTLSGLWVDNQQRYRTVMASDHLSLTKAFQKTGAWDTVGIMPGVQKGWPEQEFYGLDKVYNAFQMGYQGPKFSWSTMPDQYALEAFQRLEHGRTDRDKPLMSEIILTSSHQPWAPIPKMVGWDELGDGSVFKDIEADGEKASDVIADSDRSKKEYGKSIQYSVTALTQWLARYGTDDTVLVFLGDHQPISRVSGNNASRDVPISIVAKDPKVLDKIAAWNWTDGLKPAHDAPVWKMSSFRDRFLKAYGSTPHPSSG
>NZ_CP049838.1|WP_171402003.1|3479480_3480323_-|helix-turn-helix-domain-containing-protein
MPSRRVITGRSQEPRRRFAEELRLLRTEKGDSLRQLEVVLGWNASTFGKMEGGQSLGSPEIVEALDQHYGTAPMLLTLWELAVADPSQFKEQYRRYMLLEAEAIGLWHYGVSRPPGMLHTAGYAREALAAGGLKGEELEQQVEARIGRRKVLEGVDAPPFRMILAEAVLRNSLRDPREWREQLECLLEAAERPNVTLHVLPFGTGLHSLDTTDIMFLRLVDGRTVAYTENDVRGELVDETSRVERLHRTYDAVRDLALNPAESRTFILRMLEELPCEPST
>NZ_CP049838.1|WP_171397139.1|3480488_3480878_+|hypothetical-protein
MHDTQHEPGALFYDPATDKVGEYQERSGPYAMLRPVGGGREWQADPAALRPATAEQRLSAGVRAANRRARTDAPFMVGIGTPRPPVPEPDCAECDDLASRRESARAAHDRSAETDANVLLRSHRRERHE
>NZ_CP049838.1|WP_171397140.1|3481122_3482094_+|SGNH/GDSL-hydrolase-family-protein
MARFRTRLALLGSAAALTAGALAPAQLAGAQPAAAASYEWVALGDSYTAGVIPAAGEVFEVPRDGCERTDRSYPQVIDRDLGSLIELTNVSCGAATIEDITFNAQHPIGRHLPPFSEDPDYPFPPVPPQSEAVRSGTDVITVGVGGNTLGFADILFTCLQLGSGSGGVGTPCRDDLADNIPGRLAKVSGDYDDMLATLHERAPHAKIVTVGYPTVIPEDTSKCRYNDWEQFASITPGDLDWLRDDVLNPLNATIEKRAGEHGDAFVDLAPSTRNHSVCDAGRWVEGVFSTFPSEVAFVHPNAKGHKNAADHVSAAILNALGVN
>NZ_CP049838.1|WP_171397141.1|3482176_3483559_-|glycine--tRNA-ligase
MAADKIDTIVSLSKRRGFVFPCSEIYGGQKAAWDYGPLGVELKENLKRQWWRYMVTSREDVVGIDSSVILAPEVWVASGHVATFSDPLTECTSCHKRFRADHLEEAYEAKHHRQPENGLADVNCPNCGNKGQFTEPKQFSGLLSTHLGPTQDTGSIAYLRPETAQGIFTNFAQVQTTSRRKPPFGIAQMGKSFRNEITPGNFIFRTREFEQMEMEFFVKPGEDETWQEYWMEQRWNWYTGLGLREENMRWYDHPKEKLSHYSKRTADIEYRFQFGGNEWGELEGVANRTDYDLSAHAKASGQDLSYFDQDAQERWTPYVIEPAAGVGRAMLAFLLDAYVEDEAPNAKGKMEKRTVLRLDHRLAPVKVAVLPLSRNPELSPKAKGLAAALRQNWNIEFDDAGAIGRRYRRQDEIGTPYCVTVDFDTLDDNAVTVRERDSMKQERVSLDQIESYLAGRLIGA
>NZ_CP049838.1|WP_171397142.1|3483732_3484692_+|zinc-ABC-transporter-substrate-binding-protein
MNVRRRLISGTAIAAATALGLGTLSACSSDSAAATNTDKFDVVASFYPMAFLAEQIGGAHVNVSSLTEPGQEPHDLEISAQQTAALQKSDAVLYLKNLQPSVDDAVAQSEVKTKIDAASLTTLEKHGNEVGGHAAEHDDHENEELSGLDPHIWLDPVRYSQVAEGVGKAFEKADPDHAADYKANTAALVKKLDALNTQFKDGLANTKTKVFVTTHAAFGYLAERYGLTEEAINGLDPESEPSAARVKELEKMAKADGVTTVFYETLVSDKTAKTIASDANLETDVLDPIEGITKKSRGTDYFSVQEANLKALKTALGTK
>NZ_CP049838.1|WP_171397143.1|3484709_3485531_+|metal-ABC-transporter-ATP-binding-protein
MDASVTGAKAESVSSESVSSESVISLRGVRAELGSRPVLRGIDLTVRRGEVVALLGANGSGKSTAVRTVIGQVPVSAGEVELFGTPQRRFRDWARIGYVPQRTTAAGGVPATVTEVVSSGRLSRTRFGVFRKADREAVRHALDLVGMADRAKDNVDALSGGQHQRVLIARALAAEPELLIMDEPMAGVDLASQEVLARTLKDQVAAGTTVLLVLHELGPLEPLIDRAVVLRDGCVLHDGPPPQALGQHALPGHDHVHPHAPAGAEPIRTGLLS
>NZ_CP049838.1|WP_171397144.1|3485530_3486433_+|metal-ABC-transporter-permease
MDFLNYAFMQRALLAAVLVGITAPAVGIYLVQRRQALMGDGIGHVAMTGVGLGFLLSWSPVWMATAVSVVGAVTMELIRWYGKTRGDIALAMLFYGGMAGGVMFINLAPGGSNANLTSYLFGSLSTVSESDVTAICLLAAFVVVVTLGLRRQLFAVSQDEEFARVTGLPVRALNLLTAITAAVTVTVAMRVVGLLLVSALMVVPVAAAQQLSRSFAATFAIAVAIGVTVTTGGTVTSYYQDVPPGATIVLLTIGAFIALSVLAAPLARRRARALAAAQPAGDPAECAIPATRAAGDEVGV
>NZ_CP049838.1|WP_028806487.1|3486492_3486912_+|transcriptional-repressor
MTTAGPPVKGRSTRQRAAVAAALDEVDEFRSAQDLHDMLKHKGDSVGLTTVYRTLQSLADAGEVDVLRTSDGESVYRRCSTGEHHHHLVCRVCGKAVEVEGPAVEKWAEAIAAEHGYVNVAHTVEIFGTCSDCAGASGG
>NZ_CP049838.1|WP_171397145.1|3487020_3488376_-|histidine-type-phosphatase
MNRVTPALATALGALVLTALPAHAADTGGSGTHLAHRDSYGTKATYAPEQSARSYQRPPAGFTPVFTENVSRHGSRSATDSEDGDLILALWDKAEATGQLTGKGEEFGPKVRALQAAMAKIGYGNLSGLGKEEIQDTATRTAARLPSLFAGIARDGEKIDVVSSGQGRAVDSANLYAGALADADPALEPLIGTTRTDKDLLYFHKADGGAAYRDYIANDQRLADTLAKITDQPKTHKAAYSVLRRLFKAAFVEQLGSADQVAAAQAVYNLYAIAPAMSEESPGGKGWGMQRYISTSDAAWFGYLSDAEDFYEKGPGFADSDITYKMADVLLDDFFQQVEAKRSGTSTLGAELRFTHAEEIIPLAALMGLPGSTKPVTAAKPYTYASNPWRGADVAPLASNIQWDVYEKNGRFLVRMLYNEQETSFKAACTPISKGSKFYDLDELERCFGRG
>NZ_CP049838.1|WP_020127702.1|3488457_3489309_-|isoprenyl-transferase
MVVRGFLGRQRREYRTPEPHPSGARPPKLPGELVPEHVAIVMDGNGRWAKERGLPRTEGHKVGAEQVLDVLQGAVEMGVRNISLYAFSTENWKRSPDEVRFLMNFNRDFIRKTRDQLDELGIRVRWVGRMPKLWKSVAKELQVAQEQTKDNDRLTLYFCMNYGGRAEIADAAQALAEDVKAGRLDPSKVNEKTLAKYLYYPDMPDVDLFLRPSGEQRTSNYLLWQSAYAELVFQDVLWPDFDRRDLWRACVEFASRDRRFGGAVTNEELLAMEGKTPDQEATS

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP049838_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049838_5

4231842-4232055

Orphan

Consensus_repeat	Method
GGATTNNCGCACCCCCGCCC	CRT

5 spacers

The CRISPR arrays of NZ_CP049838_5

>merge|NZ_CP049838|5|4231842-4232055|CRT
GGATTTACGCACCCTTGCCCACAAGCCACCGCACGGGCCGCTCTACGTACCCCCGCCCACAGGGCGCCGGACGGGCTGGATTTACGCACCCCCGCCCCCAAGCCACCCCACCGGCCGGATTCCCGCACCCCCGCCCACAGGGCGCCGGACGGGCTGGATTTACGCACCCCCGCCCCCAAGCCACCCCACCGGCCGGATTCCCGCACCCCCAGCC

>NZ_CP049838|5|1|4231842-4232055|CRT
GGATTTACGCACCCTTGCCC	ACAAGCCACCGCACGGGC
CGCTCTACGTACCCCCGCCC	ACAGGGCGCCGGACGGGCT
GGATTTACGCACCCCCGCCC	CCAAGCCACCCCACCGGCC
GGATTCCCGCACCCCCGCCC	ACAGGGCGCCGGACGGGCT
GGATTTACGCACCCCCGCCC	CCAAGCCACCCCACCGGCC
GGATTCCCGCACCCCCAGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049838.1\|WP_171397648.1\|4223610_4224570_+\|2-phospho-L-lactate-transferase	unknown	unknown	gnl\|CDD\|237443
NZ_CP049838.1\|WP_171397656.1\|4240450_4241731_-\|LCP-family-protein	unknown	unknown	gnl\|CDD\|367673
NZ_CP049838.1\|WP_020128538.1\|4240008_4240371_+\|four-helix-bundle-copper-binding-protein	unknown	unknown	gnl\|CDD\|153434
NZ_CP049838.1\|WP_171397649.1\|4224566_4225913_+\|coenzyme-F420-0:L-glutamate-ligase	unknown	unknown	gnl\|CDD\|183957
NZ_CP049838.1\|WP_171402056.1\|4229027_4230608_-\|peptidoglycan-recognition-protein	unknown	unknown	gnl\|CDD\|128941
NZ_CP049838.1\|WP_171397658.1\|4242563_4243670_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173847
NZ_CP049838.1\|WP_171397652.1\|4230963_4231722_+\|TIGR03089-family-protein	unknown	unknown	gnl\|CDD\|274426
NZ_CP049838.1\|WP_171397655.1\|4238510_4239878_+\|LCP-family-protein	unknown	unknown	gnl\|CDD\|367673
NZ_CP049838.1\|WP_171397646.1\|4216484_4218032_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171397647.1\|4218028_4221733_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|224137
NZ_CP049838.1\|WP_171402057.1\|4232219_4233407_+\|LCP-family-protein	unknown	unknown	gnl\|CDD\|367673
NZ_CP049838.1\|WP_171397651.1\|4227712_4228795_-\|NDP-sugar-synthase	unknown	unknown	gnl\|CDD\|224129
NZ_CP049838.1\|WP_171397657.1\|4241851_4242412_+\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|224523
NZ_CP049838.1\|WP_171397654.1\|4237241_4238285_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133016
NZ_CP049838.1\|WP_171397650.1\|4226534_4227539_+\|DNA-3-methyladenine-glycosylase-2-family-protein	unknown	unknown	gnl\|CDD\|223200
NZ_CP049838.1\|WP_020128550.1\|4222944_4223490_+\|cysteine-dioxygenase-family-protein	unknown	unknown	gnl\|CDD\|380416
NZ_CP049838.1\|WP_171402058.1\|4235689_4237156_+\|LCP-family-protein	unknown	unknown	gnl\|CDD\|367673
NZ_CP049838.1\|WP_171397653.1\|4233649_4235428_+\|LCP-family-protein	unknown	unknown	gnl\|CDD\|367673
NZ_CP049838.1\|WP_171397659.1\|4243921_4245265_+\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223936
NZ_CP049838.1\|WP_020128551.1\|4221940_4222210_-\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791

Protein	Function_ID	Function_description	E-value
NZ_CP049838.1\|WP_171397648.1\|4223610_4224570_+\|2-phospho-L-lactate-transferase	gnl\|CDD\|237443	PRK13606, PRK13606, LPPG:FO 2-phospho-L-lactate transferase; Provisional.	7.16596e-174
NZ_CP049838.1\|WP_171397656.1\|4240450_4241731_-\|LCP-family-protein	gnl\|CDD\|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	2.64908e-56
NZ_CP049838.1\|WP_020128538.1\|4240008_4240371_+\|four-helix-bundle-copper-binding-protein	gnl\|CDD\|153434	cd08026, DUF326, Cysteine-rich 4 helical bundle widely conserved in bacteria. This functionally uncharacterized protein forms a 4-helical bundle with a bromodomain-like topology. It is present in major bacterial lineages and contains highly conserved cysteines in a repeated pattern, whose sidechains appear buried. Some family members have been (mis)annotated as putative ferredoxins.	8.5956e-19
NZ_CP049838.1\|WP_171397649.1\|4224566_4225913_+\|coenzyme-F420-0:L-glutamate-ligase	gnl\|CDD\|183957	PRK13294, PRK13294, F420-0--gamma-glutamyl ligase; Provisional.	0
NZ_CP049838.1\|WP_171402056.1\|4229027_4230608_-\|peptidoglycan-recognition-protein	gnl\|CDD\|128941	smart00701, PGRP, Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine.	1.56522e-53
NZ_CP049838.1\|WP_171397652.1\|4230963_4231722_+\|TIGR03089-family-protein	gnl\|CDD\|274426	TIGR03089, conserved_hypothetical_protein, TIGR03089 family protein. This protein family is found, so far, only in the Actinobacteria (Streptomyces, Mycobacterium, Corynebacterium, Nocardia, Propionibacterium, etc.) and never more than one to a genome. Members show twilight-level sequence similarity to family of AMP-binding enzymes described by pfam00501.	1.26012e-75
NZ_CP049838.1\|WP_171397655.1\|4238510_4239878_+\|LCP-family-protein	gnl\|CDD\|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	5.48854e-52
NZ_CP049838.1\|WP_171397658.1\|4242563_4243670_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	0
NZ_CP049838.1\|WP_171397647.1\|4218028_4221733_-\|glycosyltransferase	gnl\|CDD\|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	3.80872e-31
NZ_CP049838.1\|WP_171402057.1\|4232219_4233407_+\|LCP-family-protein	gnl\|CDD\|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	6.26278e-60
NZ_CP049838.1\|WP_171397651.1\|4227712_4228795_-\|NDP-sugar-synthase	gnl\|CDD\|224129	COG1208, GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis].	9.14015e-98
NZ_CP049838.1\|WP_171397657.1\|4241851_4242412_+\|acyl-CoA-thioesterase	gnl\|CDD\|224523	COG1607, COG1607, Acyl-CoA hydrolase [Lipid metabolism].	3.92161e-50
NZ_CP049838.1\|WP_171397654.1\|4237241_4238285_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|133016	cd02525, Succinoglycan_BP_ExoA, ExoA is involved in the biosynthesis of succinoglycan. Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.	3.15336e-93
NZ_CP049838.1\|WP_171397653.1\|4233649_4235428_+\|LCP-family-protein	gnl\|CDD\|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	4.64373e-54
NZ_CP049838.1\|WP_020128550.1\|4222944_4223490_+\|cysteine-dioxygenase-family-protein	gnl\|CDD\|380416	cd10548, cupin_CDO, cysteine dioxygenase, cupin domain. This family contains cysteine dioxygenase (CDO; EC 1.13.11.20), which catalyzes the conversion of cysteine to cysteine sulfinic acid, the first step in the biosynthesis of essential oxidized cysteine metabolites such as sulfate, hypotaurine, and taurine. CDO also plays an important role in the regulation of intracellular cysteine levels in mammals; CDO expression is altered in cancer cells, and abnormal or deficient CDO activity has been linked to Parkinson's disease, Alzheimer's disease, and rheumatoid arthritis. CDO is an iron-dependent thiol dioxygenase that uses molecular oxygen to oxidize the sulfhydryl group of cysteine to generate cysteine sulfinic acid. The CDO active site contains an amino acid-derived cofactor. These enzymes are found in prokaryotes as well as eukaryotes and belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	7.27011e-24
NZ_CP049838.1\|WP_171402058.1\|4235689_4237156_+\|LCP-family-protein	gnl\|CDD\|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	5.2309e-42
NZ_CP049838.1\|WP_171397650.1\|4226534_4227539_+\|DNA-3-methyladenine-glycosylase-2-family-protein	gnl\|CDD\|223200	COG0122, AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair].	2.59954e-24
NZ_CP049838.1\|WP_171397659.1\|4243921_4245265_+\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	gnl\|CDD\|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	0
NZ_CP049838.1\|WP_020128551.1\|4221940_4222210_-\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	1.34516e-28

>NZ_CP049838.1|WP_171397652.1|4230963_4231722_+|TIGR03089-family-protein
MTATDRTPADLLRSALAADPARPLVTFYDDATGERVELSVATFANWVAKTANLLQDGLSAEPGDRVALLLPAHWQTAVWLLACSSVGVVADVAGDPARADFVVAGPGSFEAGLACRGERYALSLAPLGRRFVPGPPEGYDDYAVNVPTFGDRFVPYVPVDPEEPALIVAGAEYTGAEVVERARAEASGLGLTGPGSRLLSGLAYDTWEGLSAGLYAPLASGGSVVLCRNLAEAGEEAVAKRVESERVTATAR
>NZ_CP049838.1|WP_171402056.1|4229027_4230608_-|peptidoglycan-recognition-protein
MPDLPDVPDLPDLPGSTQSLPLTALARDRALGGAGTDQGLPRRDVRQFSLLGVVWDDPAAELHGRVQVRTRTSGTGTWSGWQDVETHNADHGADPGTPESASGRVRGATAPLWVGDSDGVEIRVHPDTERRTEETARDTGTLSTATLLPSGLRLELVDPGSAPPEHVPAGPPRSRTLTTGSGPAAAPEAVDPPDAATEKTAETATTAEEAGAAEEAEAGERAETSEEAQGVETSEEAQGVETSEEAKGVETSEEAKGVETSDEADGAEPAAMTAMTAEATAASAANVPLAPLGATEIPALDRLGTERELLALRGDELTSAQQAKPYIGPRPSIVTRRGWGADEKLREKRFVYTTKVKAAFVHHTASGNSYKCSQAPSVIRGIYRYHVKSMGWRDIGYNFLVDKCGKIYEGRAGGVAKPVLGAHTLGFNTNSMGIAVLGTFTSAKPTTATVNAVARLTAWKLGLYGANPKGKTYLKSGGGNLYGKGKNVRLNVISGHRDGFATECPGRQLYGKLGSARSTSARYQGR
>NZ_CP049838.1|WP_171397651.1|4227712_4228795_-|NDP-sugar-synthase
MTEAILLVGGKGTRLRPLTVHTPKPMVRAAGVPFLTHQLARARAAGVDHIVLATSYLAEVFEPYFGDGSALGLHIEYVTEDEPLGTGGAIRNVASRLHSGPDDPVLIFNGDILTGLDIRRLVATHEATAADVSLHLTKVTDPRAYGLVPTDETGKVLAFLEKPQTPEEIVTDQINAGAYVFRRSVIDTIPQGRPVSVERETFPDLLSAGAHLQGMVDSTYWLDLGTPAAFVRGSADLVLGRAPSPAVPGRCGDRLVLPTARVAPDAKLTGGTVVGEGAFVAEGARVFGSTILPGAVIEPGAVITDSLIGTRARVGERSVLTGTVIGDGAIVGPDNELRDGARVWCDARIPAGAVRFSSDQ
>NZ_CP049838.1|WP_171397650.1|4226534_4227539_+|DNA-3-methyladenine-glycosylase-2-family-protein
MSGRFSPRPTRTTVRGGHVGVPVGVPRQASAAGRVRNWVPEGPLDLGLVLGPLRRGPGDPTFRALPDGSVWRASLTPAGPGTLRVAPADGAVRGEAWGPGAEWLLDRLPELLGASDAPEAFVPRHRVVATARHRRPGLRLTRTGLVLESLIPSVLEQKVTTDEAYRAWRLLVRKFGEPAPGPAAGGRLWVMPAPRTWALIPSWEWHRAGVDNKRASTILRAVRVAGRMEEAVRMTPAEAQARLEVVPGIGPWTSAETVQRSHGAADAVTVGDLHLPGIVGWALAGDREADDSVMLELLEPYAGQRHRAARLILLSGRVPPRRAPKMPRGDIGKL
>NZ_CP049838.1|WP_171397649.1|4224566_4225913_+|coenzyme-F420-0:L-glutamate-ligase
MSGSFETGYRVWAVNGLPEVRPGDDLAKLIAAAEPGLADGDVLLVTSKIVSKAEGRIVRADDREAAIDAETVRVVARRGALRIVENRQGLIMAAAGVDASNTPAGTVLLLPEDPDASARAIRAGLRDALGVDVGVVVTDTFGRPWRAGLTDVAIGAAGVRVLDDLRGGTDAYGNPLSATVVATADELAGAGDLVKGKAAGLPVAVVRGLGHVVVAENAELADAGADGGGLAGARVMVRGARDDMFRLGTSEAVRLAVTQRRTVRAFTDEPVDPGAVRRAVAAAVTAPAPHHTTPWRFVLLESAESRVRLLDAMRDAWVADLRRDGKSEESIAKRVRRGDVLRNAPYLVVPCLVMDGSHTYGDARRDAAEREMFVVATGAGVQNFLVALAGERLGSAWVSSTMFCRDVVREVLELPESWDPMGAVAVGHAAEEPRARGEREVGDFVEVR
>NZ_CP049838.1|WP_171397648.1|4223610_4224570_+|2-phospho-L-lactate-transferase
MRIVVLAGGIGGARFLRGLKQAVPDADITVIGNTGDDIHLFGLKVCPDLDTVMYTLGGGINEEQGWGRADETFHLKEELAAYGAGPGWFGLGDRDFATHIVRTQMIGAGYPLSAVTEALCDRWQPGVRLIPMTDDRVETHVAVVADGERKAVHFQEYWVRLRASVPAEAVVPVGAEQAKPAPGVLEAIAAADVILFPPSNPIVSVGTILAVPGIREAIAEAGVPVVGLSPIVGDAPVRGMADKVLAAVGVESTAAAVAEHYGSGLLDGWLVDTVDAGTVERVEAAGIRCRAVPLMMSDLDATARMAQEALALAEEVRGA
>NZ_CP049838.1|WP_020128550.1|4222944_4223490_+|cysteine-dioxygenase-family-protein
MNSDSDLQIAGDILEVPHLLQAPREHPATVAEFVGLARSIAADRAQWEHLVRYDATTRWYHRLRTGPGYEVWLLSWVPGQGSGLHDHGGSSGVLTVLDGELTERTERGKRVLGAGVQRVFAPGYAHEVVNDALEPAVSLHVYFPGLTDMPMHPRSRLHPAGRAPIACAALDTYEQVDAVSS
>NZ_CP049838.1|WP_020128551.1|4221940_4222210_-|WhiB-family-transcriptional-regulator
MTELVQQLLVDVDDADEELGWQERALCAQTDPESFFPEKGGSTREAKKVCLACEVRSECLEYALANDERFGIWGGLSERERRRLKKAAV
>NZ_CP049838.1|WP_171397647.1|4218028_4221733_-|glycosyltransferase
MSVHSHTAAHQDRAATPEFPRHVVTAVIVAHDGARWLPDALAGLLGQERPVQSVMAADTGSSDDSARLVTEALGDDRVLHLARRTGFGQAVEEANRTAPVLTPEELPYLKRPSGWDPVTRTWRDDTYDLPELPHGEPVQWLWLLHDDCAPEPDALAELLRVVDNELELGRDDVAVVGPKLRGWYDRRQLLEVGVTIAHSGRRWTGLDRREQDQGQHDHVRSVLSVSTAGMLIRRDVFEQLGGFDRRLPLMRDDVDLCWRAQAAGHRVLIAPEAVVRHAEAASRERRTVDCAGRTSASPHKVDKAGAVYTLLVNSRTALLPWILVRLVLGTLLRTVAYLVGKVPGQAVDEIRGLLGTLLRPERIIAGRRRRGKPAVDKDELRPLFPPPGATVRATVEQVAGDFFGSSDPEATSGAGRHGGAVESGPGGDDADFLEIEQFARLKRIARKPGPVLFLVLLLVSLVACRNLLGGGALAGGALLPAPADASELWSRYLDAWHPIGAGGTPSAPPYLAIIATLATLLFGSTGLALTVLLVCSVPLAGVTAYFASRPLVESRLLRAWAAVVYAFLPAATGALAGGRVGTAVLAVLLPLIARAGVAASGLTHASGARGSWRATWAYALLLTIATAFTPIVWPLALVLGVAVLAVRRREITAYGLRFLAQLGTPLLILAPWSLSLLPFGFFTQAGLDYGASTATALDLLGASPGGPGTVDGLMLIGIVLAALAALLRSERHFGVWAAWAVALLGLVFAILSNSSTWAGPATLVYGIALLAAAVIGADGARTRVAEQSFGWRQPVAALIAFASAAGPLLVAAGWMIGGADGPLERRDPVQVPAFVAEEAGNRDQARTLVLDSDSAAHVAYMLVRGSGARLGDAELAAADGENKQLDKVVANLVAGSGADQADQLGKFAVGYVLVHKGAPREVTRVLDATPGLKRLSQQDGSALWRVDQEVSRAAVVADSGKGTATPVAAGPVDIHTTVPDGSGSRVLRLADTAAEGWTATLDGKPLTPTTVDGWAQGFELPASGGKLDVTYDDPFTHTAWLWAQGFLALVLVVLALPGRRRDVDDDLPEEEPIPAQAADGEGRRARRLRAQAEAEEPGQHEEFPSPPQEGTPVAVPQQQSYDMGVPPDGQGGDWGRDQSYAGAEYGGYTGEQYQGAQQYPSGGYDQQAYDPYQTGQYDPYAYDGQAQQAPYDQTYQQQQGYDPSAYDQGGHDPAYDPDRHPHGTGSERPDGSQQ
>NZ_CP049838.1|WP_171397646.1|4216484_4218032_-|hypothetical-protein
MNRTTLSLIAGTAALAAVTGFATLNQPDAATADTAQAAAELPVERTSLLCPSPSTSDLADTSYTSFTPVTKGTDGDGTAELAAATAESAAATTDKTTDKTTDKTTDKTTDKTSSKKKATKPVVTPKAPGTPAVGDTSGGETPALLGTAEGKFAPGWTVQETTEVTAGSGRGLQGVTCTAPDTEFWFPGVSTAADRTDYVHLTNPDDSAAVADIELYGKDGALSTTVGEGITIPAHSSEPILLSTLTGEKQEDLTVHVNVRSGRVGAAVQALDEKLGGDWLAASTDPAGTQVIPGIPKDATAVRLIAYAPGDADADLKVQLASPSGLITPAGHETLHVKAGMTTSVDLGDVTRGEAGSLVLTPTGQSVPVVAAVRVLRGKGAQQESAFITATAPVGTRASAADNSAKGSTLSLTAPKGTAKVKVTASAGSGGGTAVSKTYTVKAGTTQDVELPVPTGLKGTYALTVEPLTDTPVYASRTLTATQEGVPGFTIQTLPDDRGTVAVPEADEDVAVLQK
>NZ_CP049838.1|WP_171402057.1|4232219_4233407_+|LCP-family-protein
MGASADGRGLVRRRRRRWVRYGVGAVGVVVLGVGIAGWVAYAKLDGNITPDDAAAAELARYARERPTSLVKDAQNILLIGSDSRSGDGNRKYGRDSGTERSDTTILLHLAAGRRSATAVSVPRDLMVDVPGCLRPDGKRTEPIFAMFNYAFQSGGSACTIRTVEKLTGVRIDHHVVVDFSGFKDMVDAVDGVEVCLKEPIDDKAAKLRLPAGKVTLDGEQALGYVRARKSLGNGSDTDRMDRQQRFLGALVNKVQSNDVLLNPVKLYPLLDSATSSLTTDPDLASLRGLYELVRGLRDIPTEHVQFLTVPRESYVYNANRDQLVEPEAEKLFERLRTDAPVVVSQEIPTNSAPAESGDYGPFGFRAPGPAASGAVSPTPPAPTFRGNTAAEDGCG
>NZ_CP049838.1|WP_171397653.1|4233649_4235428_+|LCP-family-protein
MDAQGRGRADNIDPADQWVLNPNTGEYELRLTPSAPQSSVPGPRRSDSGKTGGGGAARGRTAAPGGGSASSSPEETPDPEVPSPRRRRGAPPEEPAANRRGRRPVKKKSKAKKILLWTGGIMAFVLVGTAGAAYLYLEHLNDNITSVSDDGASTGGFSKDKAINLLVIGTDKRTGSGNEGYGDSGSVGHADTTILLHVSKDRTNATALSIPRDLIVDVPDCETKQEDGSTKVIKGSDGVRFNTSLGQDDRTPSCTVRTVTELTGIQADNFMVADFNAVKTLTTAVGGVEVCLAKDIDDEDSHLKLSKGTHTIEGEQALAFVRTRHSVGFGGDLSRIELQQQFLSALMRKLKSNDTLTSPTKMIKLAEAGTKALTVDSQLDTIDKLKDLGLELGKLNVKNLTFTTVPVVDNPAEKVAATVVVNASTAPTVFQMIKDDVSFTEVKEQAAASKNAAAAAAAARLKGTQSAASAVRVQVMNGGAPAGSAQETLNWLQNDEGVTKSENAGNAPAELSKTTLEYAPDQADQARKLAAIMGLPGTALKPGKSVENSQGLPTMTLTLGKDFKGAGVSLTAPTTVPDTVQKSTADKVECAK
>NZ_CP049838.1|WP_171402058.1|4235689_4237156_+|LCP-family-protein
MRWSATVLALVILGGAGAGYLYYEHLNANIKSDDLNIGDAKDRAAKTEANSAGQTALNILLIGSDARDTAENQKLGGAKDTFDGPPLADVQMLLHISADRSNMSVVSMPRDTLLDIPKCTDPDDGTTYGALTDEMTNVSLGRGGPGCTVATWEKLTDIHIDHFMMIDFSGVVSMADAIGGVPVCVDANVYSHTSTGKGSGLKLEEGTHAVKGKQALQWLRTRYGFEDDTDLARAKAQHMYMNSMVRELRANAKLTNPNKLRKLAEAATKAITVDDGLDTITKMYDLAGELKKVPTERITMTTMPNRYQGSRVVPTDDAKQLFRLVREDIALDGKDAKKATASPTPTVTDPAAAIGEIAVQVHNGTSTSALGPVSGRAKAVTQVLTGKGFTEAVADTSAATAVGATVVRYPSADLEGDAEVVAKALGIPTGQVKKSTEVSGVTVVVGADWRSGTAYKAPVKDDTTPDTAGAINASDTSQCMHVDPNYTW
>NZ_CP049838.1|WP_171397654.1|4237241_4238285_-|glycosyltransferase-family-2-protein
MNAKPDVQLPAVSVIMPVLNEERHLRGAVQAILAQEYAGEMEVVIAIGPSTDRTEEIAAELVAETASGNKRVHTVPNPSGRTPAALNAAIKASRHPIVVRVDGHGMLSPNYIATAVRLLEETGAQNVGGIMHAEGENDWEHAVAAAMTSKIGVGNAAFHTGGQAGPAETVYLGVFRRAALEQQGGYNEEFIRAQDWELNFRIREAGGLIWFSPELKVSYRPRPSVKALAKQYKDYGRWRHVVARYHEGSINLRYLAPPTAVCAIAAGIVVGAALTPLGFVIPGGYLAAIVAGSLPAGKGLPLKARLQIPVALATMHMSWGFGFLTSPKALARKVIASRRPAVLTDAH
>NZ_CP049838.1|WP_171397655.1|4238510_4239878_+|LCP-family-protein
MRATTTLSVVLLAAAGIGHSVVAGLDAEITRVDPFKDMKNRPRAGHGMNVLLVGTDGRDDITEAERRRYRLGGAPCHCTDTIMIVHISDDRERASVVSLPRDSYAETPPHTDQVTGKEHSGHPIRINSAYAEGGPQLTVRTVENMTHVKIDHYLEVDFTSFMKTVDVLGGVKICTAEPLKDAYTGLDLAPGAHTLKGGQALQYVRSRHTDASSDLGRMKHQQRFLAALVDRATSSGVLLNPLRFRDVTRAVLGSVRADRGFGTDELLDLGRAMRTFSPSSSEFTTVPIGRMNYVVKGLGSTLKWDPVKAQRLFRALREDEPLATAGARPRGDGTRVDVAPQQIHVQVENGTRTAGLGKRVDAALAATGFRTTRQPVSAADPSTRRTVVAYDPRWDRSAKSLATALPGSELRAVKGLGSTLKVIAGTDFRKVRKVRAAQVEQGESGVVRGDEVGCS
>NZ_CP049838.1|WP_020128538.1|4240008_4240371_+|four-helix-bundle-copper-binding-protein
MTQPGTMTAMSKEMQDCVEACMSCHSMCEETMSSCMQMGGQAQMQIMRALMDCSETTRMCADMMMRRSPMSAEMCAMCAKACDMCAEACMAMPDDPQMMRCAESCRRCAEMCRTMAGATM
>NZ_CP049838.1|WP_171397656.1|4240450_4241731_-|LCP-family-protein
MNDWPEGWSDSDRGNRYGGGSANAQPESPRVMRQVRRGPAAPPQGAGVPQQPSYVNGQGHGDYTNAQNTGYDSGYSSGEVYGGGGDSGGPGGLGTRAPRPAPNWRRRIKWTAITVLTVLVVTSVGTYFWADGKLNREVDLSKVIDRPEAGEGTNYLIVGSDSREGMSAEEKKELHTGSAEGKRTDSMMILHTGSNGDTLISLPRDSDVEIPTFVGSESGKTYKGTGRHVKLNAAYAEDGPELLVRTVEFNTGLRIDHYVEIGFAGFANIVDSVGGVEIDIPQDIKDTKSGADFKKGKQTLNGEEALAFVRTRYALAGSDLDRTKNQQKFLAALANQVATPGTVLNPFKLYPTMSAGLDTLIVDKDMGLYDLGSMFFAMKGVNSGDGKSMNMPISGSTGGNLVWDKAKVKTLVSQLKNDEKVTVSGN
>NZ_CP049838.1|WP_171397657.1|4241851_4242412_+|acyl-CoA-thioesterase
MTDQVTAADSGSTPDIPGKPTSASRTTLSHIMSHNDTNLLGTVHGGVIMKLVDDAAGAVAGRHSGGPAVTASMDEMAFLEPVRVGDLVHVKAQVNWTGRTSMEVGVRVLAERWNESAPPTQVGSAYLVFAAVDADGKPRVVPPVLPETERDKRRYQEAQIRRTHRLARRRAIRELRERRVAEGLED
>NZ_CP049838.1|WP_171397658.1|4242563_4243670_-|acyl-CoA-dehydrogenase-family-protein
MLRDAIRSLSEAKIAPYAAAVDEEARFPQEALDALVASDLHAVHVPESYGGAGADALATVIVIEEVARACVSSSLIPAVNKLGSLPVILSGSEDLKKKYLTPLAKGDAMFSYALSEPDAGSDAAGMKTKAVRDGDHWILNGVKRWITNAGVSEYYTVMAVTDPTKRSKGISAFVVEKSDEGVSFGAPEKKLGIKGSPTREVYFDNVRIPADRMIGEEGTGFLTAMKTLDHTRITIAAQALGVAQGAFDYAKGYVQERKQFGKAIADFQGIQFMLADMAMKIEAARQLTYAAAAKSERLDADLTFQGAAAKCFASDVAMEVTTDAVQLLGGYGYTRDYPVERMMRDAKITQIYEGTNQVQRIVMARNLP
>NZ_CP049838.1|WP_171397659.1|4243921_4245265_+|UDP-glucose/GDP-mannose-dehydrogenase-family-protein
MALKITVIGTGYLGATHAAAMAELGFEVLALDVVREKIEMLERGETPMYEPGLEELLRRHVPGFEGSSGRLRFTQDWAEVGAFGDVHFVCVNTPQKHGEYACDMSYVESAIGSLAPHLARPALVVGKSTVPVGSADRLARTIAELAPAGADAELAWNPEFLREGLAVQDTLHPDRIVVGVRSERAEALLRQVYETPIGEGSPFVVTDFPTAELVKTSANSFLATKISFINAMAEVCEAADGDVAKLAEAIGYDDRIGKKFLRAGIGFGGGCLPKDIRAFMARAGELGADQALTFLREIDSINMRQRGQMVELARQALGGGSFLGKRIAVLGATFKPDSDDVRDSPALNVAGQIHLQGGQVTVYDPKGMANARRVFPTLGYADSALEAVRGADAVLHLTEWQEFRELDPAQLGEVATTRLILDGRNALDPVLWRKAGWTYRAMGRPTA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP049838_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049838_6

4675120-4675206

Orphan

Consensus_repeat	Method
TACAGCGGCGGCGAGGGCGGCAACTGCCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049838_6

>merge|NZ_CP049838|6|4675120-4675206|CRISPRCasFinder
TACAGCGGCGGCGAGGGCGGCAACTGCCTGAAGGTCGCCCGCTGGCGCAAGTCGACGTACAGCGGCGGCGACGGCGGCAACTGCCTG

>NZ_CP049838|6|5|4675120-4675206|CRISPRCasFinder
TACAGCGGCGGCGAGGGCGGCAACTGCCTG	AAGGTCGCCCGCTGGCGCAAGTCGACG
TACAGCGGCGGCGACGGCGGCAACTGCCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049838.1\|WP_171397989.1\|4671728_4672856_-\|NADH:flavin-oxidoreductase	unknown	unknown	gnl\|CDD\|240095
NZ_CP049838.1\|WP_171397986.1\|4667440_4669012_-\|carboxylesterase-family-protein	unknown	unknown	gnl\|CDD\|365897
NZ_CP049838.1\|WP_171397990.1\|4673022_4673691_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|372616
NZ_CP049838.1\|WP_054243903.1\|4676749_4677001_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|224937
NZ_CP049838.1\|WP_171397984.1\|4665143_4666658_+\|PTS-transporter-subunit-EIIC	unknown	unknown	gnl\|CDD\|181971
NZ_CP049838.1\|WP_171397995.1\|4676477_4676753_+\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	unknown	unknown	gnl\|CDD\|376852
NZ_CP049838.1\|WP_171398001.1\|4684177_4685050_-\|trehalose-phosphatase	unknown	unknown	gnl\|CDD\|319767
NZ_CP049838.1\|WP_171402090.1\|4675605_4676439_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171397991.1\|4673675_4673903_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171397996.1\|4677110_4678733_-\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
NZ_CP049838.1\|WP_171397987.1\|4669160_4670651_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP049838.1\|WP_171397998.1\|4680044_4681361_-\|threonine-synthase	unknown	unknown	gnl\|CDD\|236065
NZ_CP049838.1\|WP_171397992.1\|4673899_4674133_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398000.1\|4682777_4684190_+\|trehalose-6-phosphate-synthase	unknown	unknown	gnl\|CDD\|340820
NZ_CP049838.1\|WP_171397993.1\|4674239_4675082_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP049838.1\|WP_171397985.1\|4666845_4667418_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_007493268.1\|4679067_4679274_-\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_CP049838.1\|WP_171397988.1\|4670845_4671700_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277347
NZ_CP049838.1\|WP_171397999.1\|4681715_4682660_+\|glucosyl-3-phosphoglycerate-synthase	unknown	unknown	gnl\|CDD\|237556
NZ_CP049838.1\|WP_171397997.1\|4679772_4680048_-\|MoaD/ThiS-family-protein	unknown	unknown	gnl\|CDD\|340594

Protein	Function_ID	Function_description	E-value
NZ_CP049838.1\|WP_171397989.1\|4671728_4672856_-\|NADH:flavin-oxidoreductase	gnl\|CDD\|240095	cd04747, OYE_like_5_FMN, Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Other members of OYE family include trimethylamine dehydrogenase, 2,4-dienoyl-CoA reductase, enoate reductase, pentaerythriol tetranitrate reductase, xenobiotic reductase, and morphinone reductase.	0
NZ_CP049838.1\|WP_171397986.1\|4667440_4669012_-\|carboxylesterase-family-protein	gnl\|CDD\|365897	pfam00135, COesterase, Carboxylesterase family.	3.4229e-121
NZ_CP049838.1\|WP_171397990.1\|4673022_4673691_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|372616	pfam13489, Methyltransf_23, Methyltransferase domain. This family appears to be a methyltransferase domain.	8.4344e-09
NZ_CP049838.1\|WP_054243903.1\|4676749_4677001_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|224937	COG2026, RelE, Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning].	1.39597e-07
NZ_CP049838.1\|WP_171397984.1\|4665143_4666658_+\|PTS-transporter-subunit-EIIC	gnl\|CDD\|181971	PRK09586, murP, PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed.	3.00246e-103
NZ_CP049838.1\|WP_171397995.1\|4676477_4676753_+\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	gnl\|CDD\|376852	pfam02604, PhdYeFM_antitox, Antitoxin Phd_YefM, type II toxin-antitoxin system. Members of this family act as antitoxins in type II toxin-antitoxin systems. When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin. This domain complexes with Txe toxins containing pfam06769, Fic/DOC toxins containing pfam02661 and YafO toxins containing pfam13957.	3.65345e-09
NZ_CP049838.1\|WP_171398001.1\|4684177_4685050_-\|trehalose-phosphatase	gnl\|CDD\|319767	cd01627, HAD_TPP, trehalose-phosphate phosphatase similar to Escherichia coli trehalose-6-phosphate phosphatase OtsB and Saccharomyces cerevisiae trehalose-phosphatase TPS2. Trehalose biosynthesis in bacteria is known through three pathways - OtsAB, TreYZ and TreS. The OtsAB pathway, also known as the trehalose 6-phosphate synthase (TSP)/ Trehalose-6-phosphate phosphatase (TPP) pathway, is the most common route known to be involved in the stress response of Escherichia coli. It involves converting glucose-6-phosphate and UDP-glucose to form trehalose-6-phosphate (T6P), catalyzed by TPS, the product of the otsA gene, this step is followed by the dephosphorylation of T6P to yield trehalose and inorganic phosphate, catalyzed by a specific TPP, the product of otsB gene. This OtsAB (or TSP/TPP) pathway, is also the most common route known to be involved in the stress response of yeast In Saccharomyces cerevisiae, the corresponding enzymes, TPS1p and TPS2p, form a multimeric synthase complex together with additional regulatory subunits encoded by Tsl1 and Tps3. Trehalose is a common disaccharide accumulated by organisms as a reservation of carbohydrate and in response to unfavorable growth conditions. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.16398e-33
NZ_CP049838.1\|WP_007493268.1\|4679067_4679274_-\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	2.3447e-34
NZ_CP049838.1\|WP_171397996.1\|4677110_4678733_-\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NZ_CP049838.1\|WP_171397998.1\|4680044_4681361_-\|threonine-synthase	gnl\|CDD\|236065	PRK07591, PRK07591, threonine synthase; Validated.	0
NZ_CP049838.1\|WP_171398000.1\|4682777_4684190_+\|trehalose-6-phosphate-synthase	gnl\|CDD\|340820	cd03788, GT20_TPS, trehalose-6-phosphate synthase. Trehalose-6-Phosphate Synthase (TPS, EC 2.4.1.15) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a nonreducing disaccharide present in a wide variety of organisms and may serve as a source of energy and carbon. It is characterized most notably in insect, plant, and microbial cells. Its production is often associated with a variety of stress conditions, including desiccation, dehydration, heat, cold, and oxidation. This family represents the catalytic domain of the TPS. Some members of this domain family coexist with a C-terminal trehalose phosphatase domain.	7.15308e-140
NZ_CP049838.1\|WP_171397993.1\|4674239_4675082_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	3.80459e-08
NZ_CP049838.1\|WP_171397987.1\|4669160_4670651_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.12608e-46
NZ_CP049838.1\|WP_171397988.1\|4670845_4671700_-\|metallophosphoesterase	gnl\|CDD\|277347	cd07402, MPP_GpdQ, Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain. GpdQ (glycerophosphodiesterase Q, also known as Rv0805 in Mycobacterium tuberculosis) is a binuclear metallophosphoesterase from Enterobacter aerogenes that catalyzes the hydrolysis of mono-, di-, and triester substrates, including some organophosphate pesticides and products of the degradation of nerve agents. The GpdQ homolog, Rv0805, has 2',3'-cyclic nucleotide phosphodiesterase activity. GpdQ and Rv0805 belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	3.75655e-48
NZ_CP049838.1\|WP_171397999.1\|4681715_4682660_+\|glucosyl-3-phosphoglycerate-synthase	gnl\|CDD\|237556	PRK13915, PRK13915, putative glucosyl-3-phosphoglycerate synthase; Provisional.	1.39302e-177
NZ_CP049838.1\|WP_171397997.1\|4679772_4680048_-\|MoaD/ThiS-family-protein	gnl\|CDD\|340594	cd17074, Ubl_CysO_like, ubiquitin-like (Ubl) domain found in Mycobacterium tuberculosis CysO and similar proteins. CysO, also termed 9.5 kDa culture filtrate antigen cfp10A, together with CysM (Cysteine synthase M), forms a protein complex CysM-CysO that represents a new cysteine biosynthetic pathway in Mycobacterium tuberculosis. The replacement of the acetyl group of O-acetylserine by CysO thiocarboxylate to generate a protein-bound cysteine is catalyzed by CysM in a pyridoxal 5?-phosphate (PLP)-dependent manner. The family also includes QbsE that functions as the sulfide donor for the biosynthesis of thioquinolobactin in Pseudomonas fluorescens. A JAMM motif protein QbsD catalyzes removal of the carboxy-terminal dipeptide from QbsE. Both CysO and QbsE are similar to prokaryotic sulfur carrier proteins such as ThiS and MoaD, containing the beta-grasp ubiquitin-like fold.	1.60149e-43

>NZ_CP049838.1|WP_171397993.1|4674239_4675082_+|helix-turn-helix-transcriptional-regulator
MPGPKGLDPSSSPRALLGAELRHAREKKGLSQSELGEPLFVSGSFIGQLEAGTRRLHLEYAVQVDEILGTNGFFERNCKALAKSRYPDHFVEAAEAEAIATAISEYAQMLIPGLLQTKAYATGVFRAYKPTALDGEIDDLVATRLERASLLADPTTPLLWVILDEAVLRREVGSGTVMAEALRHVADLARRRRIIVQVLPFGAGAHASMHGSLKLMEFEDAPPLSFVEAPDMGKLLDDPAAVARHTLMFNLLQATALSPQQSLALLESVAQDYEHGEEHP
>NZ_CP049838.1|WP_171397992.1|4673899_4674133_-|hypothetical-protein
MGEMGTTTGDRPARTVQEAVEQLRAALHDAGIILPSLRIDPVSGAHGDPYALVDLGRCNLRVASRLAAALRGAGGDA
>NZ_CP049838.1|WP_171397991.1|4673675_4673903_-|hypothetical-protein
MSGEYVLDARSGRIGEVMERLEGRVVLRPVGGGREWECLPEDVEEAAPAEVLRERVRRLNRETRSREEAVGQEAV
>NZ_CP049838.1|WP_171397990.1|4673022_4673691_+|methyltransferase-domain-containing-protein
MPKPPLLSSPELERSSVVANNTMNRERGLTGVNSYARELGVDLLAHLAHRPAPSWLDLCSGEGRALREAASALPAEAVLTAVDLVGPLAPRSAPPALEEIVASVSSWTPPRTYDLITCVHGLHYIGDQLGLLTRAASWLTEDGLLAAHFDPESVRHADGSPAARPALSALRAAGYSYSPRHHRLTLRGGRPVQLPFHYLGADPTAGPNYTGQPAIASYYTAS
>NZ_CP049838.1|WP_171397989.1|4671728_4672856_-|NADH:flavin-oxidoreductase
MSITPPAASRAADILARPVSINGLTVPNRIAMAPMTRMFSPDGVPGEDVVSYYGRRAAAGVGLIVTEGTYVGHESAGQSDRVPRFHGAEQLAGWAKVAEAVHAGGGTIVPQLWHIGMVRNQGEPPFADAPAVGPSGIRVDGTEGTGKAMTQRDLDDVIGAFAEAAAAAERIGFDGVELHGAHGYLLDQFLWAGTNRRTDAYGGDAVARAKFAAEIVAAVRETVSADFPIIFRYSQWKQEAYDARLAETPEELEAILAPLAAAGVDAFHASTRRYWLPEFDGSDLNLAGWTKKLTGKPTITVGSVGLDGDFLKGFAGEGAPVKGIDDLLDRLERDEFDMVAVGRALLQDPEWAAKVLDGRLDELKPYDAAALRTLS
>NZ_CP049838.1|WP_171397988.1|4670845_4671700_-|metallophosphoesterase
MRILHLSDTHIGRVDGPDGRRVDAADSLRLLLGELRHLRDVDAVVVTGDLADDGSVEAYTTVRELIGGFARSLDAPVFYTTGNHDERSAFTKVLGSGHPDAVLDFPGAERAAVSTVGGWRLVTLDSLVPEKVYGRLGAGQLDWLRSVLSTPAELGTVVAFHHPPISLDISATQQVFGLRDPEGLAEVIRGSDVRVLLTGHFHLQLFGLLAAVPVWVTPGVVNRIDLTTAPGTERAVRGASASLVELGGATGPMFHTLHARDPRAHETVYELDEERTREVIARHG
>NZ_CP049838.1|WP_171397987.1|4669160_4670651_-|MFS-transporter
MSDALARPAAAGTSAPPRSNAVVAVLALAGIVVSLMQTLVIPIVPELPKLLDAPASDTAWAVTATLLAAAVATPVVGRLGDMVGKRRMLLTSIVLLVSGSVVCALADSLVPMIAGRALQGLSAAVVPLGISILRDTVSAEKLAGSTAVMSASLGVGGALGLPTAAFIADNWDWHILFWTSATLGVVSFLLVLVFVPESQNRVGGRFDLVGSLGLSAGLVSLLLAVSKGADWGWTSGTTLGLGAAAVLILAAWGWWELRAKQPLVDLRTTAKPQVLFTNLASIALGFSMFAMSLVLPQLLQLPEQTGYGLGRSMLTVGLVLAPQGLVMMVMSAVSAKITKAKGPKVTLMIGALIVASGYGLNILLMSEVWHLILVSCIIGAGVGFTYGALPALIMGAVDPSQTGAANSLNTLMRSLGTSFASAIAGVILAQMTTDFGGYALPSENGFKVVMAIGAGAALAAFLLATFIPKRKAPAGLSVVEDAAGTEGAEEAAPVKA
>NZ_CP049838.1|WP_171397986.1|4667440_4669012_-|carboxylesterase-family-protein
MTTPDATATDRLVARTAAGAVRGRREEDLTVFRGIPFAAPPVGEARFQAPRPPHPWDGIREAYAFGPPPPQEAGIQGRAGILDAPTGDDWLTVNVWTPDTEPDPSAARPVMVWIYGGAYKLGHSGSPGYDAQHLARAGDLVIVTFNYRVGIEGFARIEGAPANRGLLDQVAALEWVRDNIAAFGGDPGRVTVFGESAGAGSVAALLAMPSARGLFGRAIAQSVPGTYFSDELARDLASAIAAEAGLRPTAADLATVDPRTLTEAGAALGAKMAQRVDRWGQAAPTVTPFSPVVDGEILPTTPWQALAAGAARDVELIVGHNAQEFRLFLVLGGLLGKVTEEQATAVLRLFAPGGGAEGEQAYRSAFPDADPGELYERVQSDWLFHLPSLHLAEAQVAGGGRAHVYELTWPAPGAGGTLGACHGLDIPLLFGTYAADLGNLLFAGAEVTDEARALTANFQRSWTSFARTGDPGWPAYDPERRLIQVLDAEPEVRPYPEETSRRLWEGHGFPPLPLLDGGVRDRA
>NZ_CP049838.1|WP_171397985.1|4666845_4667418_+|hypothetical-protein
MNHAQLTALGRALRLLGEHGEALAADTPDTRLHEVKADLRRALDLLDDSVVGATPTTRCAEHPHGPVDEAAPDLCLLCETRRRAARRAEFNGPAPQAPYTPTPSTSRYGTRADRPQPQQRWLAELWTGQEWQLCGTPRRDRREAELYIAALRRGSRPAMAYRLVHEFTDYEVLRIWGTPVKVDIEPLGNL
>NZ_CP049838.1|WP_171397984.1|4665143_4666658_+|PTS-transporter-subunit-EIIC
MRRAAEPHARGVRIDSSSTAAAILPLVGGPANVTSVAHCMTRLRLGLADPSRADEEALRALPGVLGVVVDDGSYQVVLGPGVVTRVTADFEQLLARPSTADELGARGAELREERRRGNATPFKAGLRRLAAVFVPLIPALIGCGILAGINGLLLNAGWLPGLTPALTAVASAFMALIAVFVGHNTAKEFGGTPILGGAVAAIVVYPGVAKVTAFGVTLAPGQGGVLGALAAALLATRVEKWCRGRVPEALDVLLTPTLTVLVAGLGTLYGLMYAAGAVSAAIGTGANWLLATTGAFAGLVLGGLFLPLVMLGLHQALIPIHTTLIDQQGYTVLLPVLAMAGAGQVGAAVAVYVRLRHDTSIRTTIRSALPAGLLGVGEPLIYGVSLPLGRPFLTACAGGAAGGAFVGFFAMLGDKVGATAIGPSGWALFPLLAGNRGLGPTAAVYAGGLLTGYAVGFAATYAFGVTDRVTARVTAGATSRGSEGGSKSEGGSGGPGGPTPRRSG
>NZ_CP049838.1|WP_171402090.1|4675605_4676439_+|hypothetical-protein
MANPGYGKRSAPGQLRRTRHDFAHLPPREAAIAAYIDRLPDGTDISVKTLAKQLPYGQCALRTALNRIQQAGHLRRGRERMETASGESRWITRTWFTRTARDDGWWVTFTRGDVPEDAPDPERTRPATRSRAHILLAALGRTTPALSLSAADCAQLAPLVEEWFARGATEGTLLAALTAGLPTPVHSPAALLHRRLTDKIPPEPPAPRPPRRILECAECGVPGQPEALPGGVCSGCRGECRPAHPPAPVPTSTIHAHAAGIRAAMSQRRPERTATSR
>NZ_CP049838.1|WP_171397995.1|4676477_4676753_+|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin
METYPLVEARNQLGQLVGRVRHGQEHILITEYGRPAAALIPISELEELQRLRDEADIAEARAREAVPSGRSMSHDAFMDQLEAEDRQEASS
>NZ_CP049838.1|WP_054243903.1|4676749_4677001_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MTHAVVWEQHAMAEFRRLRAIDPVGAKATAAAVRALADEPRPEAASALGTSGYYRLHIGNWRVLYRPDGDTVTVYVLKVGRSN
>NZ_CP049838.1|WP_171397996.1|4677110_4678733_-|chaperonin-GroEL
MAKIIAFDEEARRGLERGMNQLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVKEGLRNVAAGANPMALKRGIEKAVEAVSGALLEQAKDVETKEQIASTASISAADTQIGELIAEAMDKVGKEGVITVEESQTFGLELELTEGMRFDKGYISAYFATDMERMEAVLDDPYILIANSKIANVKDLLPLLEKVMQGGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLNDIAILTGGEVISEEVGLKLENTSIDLLGKARKVVITKDETTIVDGAGSSDQVAGRVNQIRAEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVALIQASAVFEKLELEGDEATGANAVRIALEAPLKQIAVNGGLEGGVVVEKVRNLPIGHGLNAATGEYVDMIAEGIIDPAKVTRSALQNAASIAALFLTTEAVIADKPEKASAPAGGGMPGGDMDF
>NZ_CP049838.1|WP_007493268.1|4679067_4679274_-|cold-shock-protein
MAQGTVKWFNAEKGYGFIAVDGGADVFVHYSAIQMDGYRTLEEGQRVDFEISQGQKGPQADMVRLATG
>NZ_CP049838.1|WP_171397997.1|4679772_4680048_-|MoaD/ThiS-family-protein
MSVNVRIPTILRTYTGGQAEVKAEGATLGEVIADLEKNHTGIAARVLDDQGKLRRFVNVYVNDDDVRFEQGLETATPDGAGVSIIPAVAGG
>NZ_CP049838.1|WP_171397998.1|4680044_4681361_-|threonine-synthase
MAAQTVASTTDASTTDSTTSSAVDLGPAAALTCRECGHRVPLGPVFACEECFGPLEIAYDFSSYDTEELRKRIEAGPANIWRYAPLLPVPADVADKPNINPGWTKLVQADNLARELGVDAGKLFVKDDSGNPTHSFKDRVVAQAIEAARAFGFTTLSCSSTGNLAGAVGAAAARAGFRSCVFIPHDLEQGKVVMAAIYGGELVGIEGNYDDVNRFCSELIGDSAGEGWGFVNVNLRPYYAEGSKTLAYEICEQLGWRLPDQLVVPIASGSQLTKIDKGLQELIKLGLVEDKPYKIFGAQAEGCSPVSVAYKAGHDVVRPQKPNTIAKSLAIGNPADGPYVLDIARRTGGAVEDVNDEQVVDAIKLLARTEGIFAETAGGVTVGVTRKLIENGLLDPTKTTVVLNTGDGLKTLDAVAGTGLTATIRPNLDSFREAGLAS
>NZ_CP049838.1|WP_171397999.1|4681715_4682660_+|glucosyl-3-phosphoglycerate-synthase
MLQETERWLATRSWSATDRPLHRILAAKRATNQSVSVVLPALNEEETVGDIVAIIRHDLMHQVPLVDEIVVVDSGSTDRTSEVAAAAGARVVHRDDILPRIPAVPGKGEVLWRSLLVTTGDIVCFIDADLREFSSDFVSGIVGPLLTDPGVDLVKGMYDRPLGGAAGQGGRVTELMARPLLNMHWPQLAGFVQPLGGEYAARRSLLEQLPFPVGYGVELGMLVDALHLVGLDALAQVDIGVRKHRHQDGQALGRMAAAIYRTAQLRLARGHLIRPSLTQFERSTDGFEPRTYSVDTEERPPMAEIAEYATRKVA
>NZ_CP049838.1|WP_171398000.1|4682777_4684190_+|trehalose-6-phosphate-synthase
MASTHDTPARAAEVLVASNRGPVSYEVREDGTLHAKRGGGGLVSGLSAIGPDTGALWVCSALSDGDREAVRRGVGEEGVRMLAVPADVHEDAYNGIANSVLWFVHHLLYQTPLEPTFDAEFRRQWASYETYNRAFAEALAQEAADGAAVLVQDYHLCLVPGMLRELRPDLRIGHFSHTPWAPVDYFALLPGDVRERLLHGMLGADRLGFLTRRWADAFTACCTEFAGGPGKTQIGVHGLGADAEFLRERSHRPDVDERMAALRAEIGEGRKAIVRVDRTELSKNIVRGLLAYRQLLDDHPEWRERVVHVAFAYPSRQDLAVYRDYMAEVQRLAEEINARYGTPGWTPVLLNLKDDFARSLAAYRLADVALVNPIRDGMNLVAKEIPVVSDEGCALVLSREAGAYWELREDAITVNPYDVLETARALYEGLTMKAEERAERTKRLSAAATALPPAQWFLDQLNALREIQPS
>NZ_CP049838.1|WP_171398001.1|4684177_4685050_-|trehalose-phosphatase
MGTHETHSTDSEPLSLPVPVTPAGRAALDAILDRPSTTLVALDFDGTLAPIVENPEDARAHPDAVPALTALAPKVAAVAVITGRPAEVAVRHGGFAGAEGLEHLSVLGHYGAERWDARTGALSAPAPHPGVAAVRAELPRVLAAAGDRPGVSVEEKGGRAVAVHTRRADDPRAAFEALRAPLTDLAGRHGLIVEPGRMVLELRPPGMDKGVALLEHVRETGARSVLYAGDDLGDLPAFAAVEKLRADGVPGLLVCSGSSEVGELAERADLVVDGPAGVVRLLRELVAQLG

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP049838_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049838_7

4931181-4931369

Orphan

Consensus_repeat	Method
GCCGCCCTGCTGGTTCTGGCC	CRT

3 spacers

The CRISPR arrays of NZ_CP049838_7

>merge|NZ_CP049838|7|4931181-4931369|CRT
ACCGCCCTGCTGGTTCTGGCCCTGGCCCTGCGTGTTGCCGTTGCCGTTCTGGGTGCCGCCGTTGCCGTTCTGCTGGTTCTGGCCGGGCATGCCCCCGCCGGGGAAGCCGCCGGTGCCGCCACCCTGCTGGTTCTGGCCCTGGCCCTGACCCTGGTTCTGCGTGTTGCCGTTGCCGTTCTGGTTCTGGCC

>NZ_CP049838|7|2|4931181-4931369|CRT
ACCGCCCTGCTGGTTCTGGCC	CTGGCCCTGCGTGTTGCCGTTGCCGTTCTGGGTGCCGCCGTT
GCCGTTCTGCTGGTTCTGGCC	GGGCATGCCCCCGCCGGGGAAGCCGCCGGTGCC
GCCACCCTGCTGGTTCTGGCC	CTGGCCCTGACCCTGGTTCTGCGTGTTGCC
GTTGCCGTTCTGGTTCTGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049838.1\|WP_171398161.1\|4920855_4921767_+\|RNA-polymerase-sigma-factor-SigF	unknown	unknown	gnl\|CDD\|274373
NZ_CP049838.1\|WP_171398172.1\|4937563_4938439_-\|DUF2797-domain-containing-protein	unknown	unknown	gnl\|CDD\|378524
NZ_CP049838.1\|WP_171398171.1\|4937101_4937452_-\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|225209
NZ_CP049838.1\|WP_171398170.1\|4934559_4936185_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|274368
NZ_CP049838.1\|WP_171398174.1\|4938899_4939397_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP049838.1\|WP_171398166.1\|4928163_4928928_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367243
NZ_CP049838.1\|WP_171398164.1\|4926772_4927594_+\|YceI-family-protein	unknown	unknown	gnl\|CDD\|377274
NZ_CP049838.1\|WP_171398160.1\|4919643_4920552_+\|RNA-polymerase-sigma-factor-SigF	unknown	unknown	gnl\|CDD\|274373
NZ_CP049838.1\|WP_171398167.1\|4929063_4930548_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|184957
NZ_CP049838.1\|WP_171398177.1\|4941309_4945881_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP049838.1\|WP_020131327.1\|4936181_4936922_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP049838.1\|WP_054242211.1\|4923574_4924102_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP049838.1\|WP_171398165.1\|4927643_4928114_+\|PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274679
NZ_CP049838.1\|WP_171398169.1\|4933003_4934545_-\|bifunctional-glycosyltransferase-family-2/GtrA-family-protein	unknown	unknown	gnl\|CDD\|133031
NZ_CP049838.1\|WP_171398173.1\|4938359_4938785_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398175.1\|4939616_4939832_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398163.1\|4924115_4926692_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP049838.1\|WP_171398176.1\|4940440_4940971_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_054242212.1\|4922705_4922903_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398162.1\|4921821_4922592_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030

Protein	Function_ID	Function_description	E-value
NZ_CP049838.1\|WP_171398161.1\|4920855_4921767_+\|RNA-polymerase-sigma-factor-SigF	gnl\|CDD\|274373	TIGR02980, SigBFG, RNA polymerase sigma-70 factor, sigma-B/F/G subfamily. This group of similar sigma-70 factors includes clades found in Bacilli (including the sporulation factors SigF:TIGR02885 and SigG:TIGR02850 as well as SigB:TIGR02941), and the high GC gram positive bacteria (Actinobacteria) where a variable number of them are found depending on the lineage.	2.26272e-126
NZ_CP049838.1\|WP_171398172.1\|4937563_4938439_-\|DUF2797-domain-containing-protein	gnl\|CDD\|378524	pfam10977, DUF2797, Protein of unknown function (DUF2797). This family of proteins has no known function.	3.16987e-43
NZ_CP049838.1\|WP_171398171.1\|4937101_4937452_-\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|225209	COG2329, COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only].	9.44035e-12
NZ_CP049838.1\|WP_171398170.1\|4934559_4936185_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|274368	TIGR02966, Phosphate_regulon_sensor_protein_PhoR, phosphate regulon sensor kinase PhoR. Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems].	2.12365e-61
NZ_CP049838.1\|WP_171398174.1\|4938899_4939397_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	3.97906e-18
NZ_CP049838.1\|WP_171398166.1\|4928163_4928928_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|367243	pfam02909, TetR_C, Tetracyclin repressor, C-terminal all-alpha domain.	3.86254e-12
NZ_CP049838.1\|WP_171398164.1\|4926772_4927594_+\|YceI-family-protein	gnl\|CDD\|377274	pfam04264, YceI, YceI-like domain. E. coli YceI is a base-induced periplasmic protein. The recent structure of a member of this family shows that it binds to poly-isoprenoid. The structure consists of an extended, eight-stranded, antiparallel beta-barrel that resembles the lipocalin fold.	1.29513e-55
NZ_CP049838.1\|WP_171398160.1\|4919643_4920552_+\|RNA-polymerase-sigma-factor-SigF	gnl\|CDD\|274373	TIGR02980, SigBFG, RNA polymerase sigma-70 factor, sigma-B/F/G subfamily. This group of similar sigma-70 factors includes clades found in Bacilli (including the sporulation factors SigF:TIGR02885 and SigG:TIGR02850 as well as SigB:TIGR02941), and the high GC gram positive bacteria (Actinobacteria) where a variable number of them are found depending on the lineage.	2.52029e-114
NZ_CP049838.1\|WP_171398167.1\|4929063_4930548_-\|MFS-transporter	gnl\|CDD\|184957	PRK14995, PRK14995, SmvA family efflux MFS transporter.	1.54596e-65
NZ_CP049838.1\|WP_171398177.1\|4941309_4945881_+\|PAS-domain-containing-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	4.23997e-20
NZ_CP049838.1\|WP_020131327.1\|4936181_4936922_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.19106e-82
NZ_CP049838.1\|WP_054242211.1\|4923574_4924102_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.27409e-17
NZ_CP049838.1\|WP_171398165.1\|4927643_4928114_+\|PPOX-class-F420-dependent-oxidoreductase	gnl\|CDD\|274679	TIGR03618, Rv1155_F420, PPOX class probable F420-dependent enzyme. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity].	2.60901e-38
NZ_CP049838.1\|WP_171398169.1\|4933003_4934545_-\|bifunctional-glycosyltransferase-family-2/GtrA-family-protein	gnl\|CDD\|133031	cd04188, DPG_synthase, DPG_synthase is involved in protein N-linked glycosylation. UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.	9.91461e-79
NZ_CP049838.1\|WP_171398163.1\|4924115_4926692_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.23619e-57
NZ_CP049838.1\|WP_171398162.1\|4921821_4922592_+\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.00019143

>NZ_CP049838.1|WP_171398167.1|4929063_4930548_-|MFS-transporter
MTTPPSLPGSSPGHPQRWLILGVICLAQLTVLLDNTVLNVAIPSLTRELDATTADIQWMINAYSLVQSGLLLTAGSAADRYGRKKMLIAGLALFGVGSLAAGLSDTTAQLIAARAGMGVGGALLFTTTLAVVMQVFVTEEQPKAIGIWAAVNSLGFATGPLIGGFVLNHFWWGAIFLINLPVAALGLVAVVALVPETKNPQGDRPDLLGAFLSTVGMTSLVFAIISGPSHGWTSSRVLVSGGLAVVVLALFAYWESRIPYPMLDLAFFRDRRFTGAVAGAVLVTFGMGGALFLLTQQLQFVLGYGPLEAGLRTAPLALTVVALNFTGLSAKVMVRLGGPVSVLVGMALVAGGLTAIATLASGGYSGMLIGLLLIGAGTSVASPAMAYAIMSSIPPAKAGVGAGVNGTLAEFGTGLGVAVLGAVLNARFAAVSLPVALAAANSVAEKARVIDSFSSGLEVSLLIGAAAVLLGGVVAAALLTRAERKEEPSVPVAS
>NZ_CP049838.1|WP_171398166.1|4928163_4928928_-|TetR/AcrR-family-transcriptional-regulator
MAETAKGAAHRSVWLEGKARRRGRGGGQPSGLDRDRITETTVRLLDAEGLAKFSMRRLAAELNVTAMSVYWYVDTKDDLLELALDAAFGELTALPDPTDEDADWREQLRALATEYRGLLVRHPWLSPLAGHYLNIGPNSLVFSRTVQQVVIRTGLPARGITGAISAVFQFVYGYGTIEGHFFARVADTGLTPDEYFHQAMTATAGAPQTAEIIEESKTLMAARGGDTVEEMMSRDFTFALDLLIAGIEAMVKRG
>NZ_CP049838.1|WP_171398165.1|4927643_4928114_+|PPOX-class-F420-dependent-oxidoreductase
MAPNIATNTKVSLDELLDFVRPRHRAILLTRRADGSSQASPLTCGVDDSGRIVVSTYPERAKTRNAKRDERVGVLVLSDDWNGPWVQIDGTAEVIDTPDSVEPLVEYYRNIAGEHPDWDEYRKAMLKQGKSIIRITPERWGPVATGGFPARLVTDQ
>NZ_CP049838.1|WP_171398164.1|4926772_4927594_+|YceI-family-protein
MGLTAKIRTRDGWAVSHAVVTVTDMAGGQVLRAEADGEGAVRDATALAPGAYTVIVTAVGYAPAASSAIVTASGRAEVGTVTLARQGGTELPPPGPWTVDPAHSAVGAVAQHLGISSVRGRFTEFSAAIEVAPDDIAKSRVEAVIRAASIDTGNAMRDTHLRSADFLDVETYPEITYRSSGLTPAGPDRWTVHGELSLHGVARPVDLDLAYLGTGSDPWGGTRAAFRATAELHREDFAMNYNQVVQAGIAAIGTTLKVELDVQAVQGGALPQA
>NZ_CP049838.1|WP_171398163.1|4924115_4926692_+|MFS-transporter
MATTTPAGVRAHAKHGGGSHGSAEATPMTHRQIMEALSGLLLGMFVAILSSTIVSNALPEIIGDLGGGQSAYTWVVTATLLSMTATTPLWGKLADLYPKKALVQIALVIYVLGSAAAGLSQNPGMLIACRVVQGVGVGGLSALAQIVMAAMISPRERGRYSGYLGATFAVATVGGPLLGGVITDTSWLGWRWCFYVGVPFAVIALIVLQKTLHLPVVKRDVKVDWAGAFFISAAVSLLLVWVTFAGDKYDWLSWQTYAMVAGSIALGLIFVLVESKATEPIIPLRLFRNRTITLSSIASMFVGVAMFSGTVFFAQYFQLARDKSPTMSGVMTIPMIGGLFVSSTVSGQFITKTGKWKAWLVSGGVLITAGLGLLGTIRYDTDYWKTAVFMALLGLGVGMMMQNLVLSTQNQVEPKDLGSASSTVTFFRSLGGAMGVSALGAVMANRITDYAKDGITDLGPKYASLASGSSSSSSIPDMDKLPAPLRTVMESAYGHGIADVFLIASVLALLALLITLFIKEVPLRTKGALAQAATAEAETPATATTPATATTAAAAAPAAVTAPAEEHVPSWAVADTAAEPGQEAGPQGTQRLAAVATAEPLQAPSGGIPVHGFVRGAESAPVPQAAVTLISLAGRQLGRSVAQADGSYGLDAPGTGSYVLIASADGFQPQASTIVVNGEPVAYDILLSGTSGLSGVVRAAESGEVVKDAMVIVTDVRGDLLATAATGDQGEFSFAELVPGAVTVAVNAVGFRPRALPVEVGATGVTRAEVVLEAGAQLQGVVRAPYGPLADARVTLVDAAGNVVGTATTGADGAYAFADLDGGEYTVIATGYPPVATALTVAGVGVDGHDIELAHPGE
>NZ_CP049838.1|WP_054242211.1|4923574_4924102_+|MarR-family-transcriptional-regulator
MAGQAQYEELARQLSAVGAVKRDLGRILPPDCSAGSAGVLALLGRHGDMRMSALSELLAVDMSVTSRHAAHLADRGWIERSPDPADKRSRILHLTPEGHAMLVELSRRSTELLAERLGDWTDAEVGRLIALLTRLRASFGDCRTVTHRPPAPPAPPPPVPVSEQTPTTRTPAQAT
>NZ_CP049838.1|WP_054242212.1|4922705_4922903_-|hypothetical-protein
MANTQGPQGNHDPAGSTQMFRAFVDDGAPRAAQPAPTQSGPRIGLIVGIVAAVVIVAAVAWLALK
>NZ_CP049838.1|WP_171398162.1|4921821_4922592_+|hypothetical-protein
MRSPTRARGRRGAVWGASAAAVVMAAAGLAAGCGGDGRTGGYVAIGGAGDTALPDARTGDSADPTGGVRLVPLDDESGSPAGKAGPGVPARETAGHGPEDTAGGGAGSGAPGTAAPAVPGASGTPSAEGGSSAGHTPPDAPSPAPTAPSSTAPAGPASLAVSDPVHAGTDQRWCEDVTLTFRNSGGTAVRSGTVTFGTHVIDALGIDWATRESTAALPTPIAAGARKEKTWTVCVDAWRVPLGMHIETRDVSVRWE
>NZ_CP049838.1|WP_171398161.1|4920855_4921767_+|RNA-polymerase-sigma-factor-SigF
MSADQGSSKVLTLTKSESAPSAPVEPAVLDVLDDVTAPEATPAPALTTTGAIDTRTLSRSLFLRLATLAEDSPERMYVRDTLIELNLPLVRYAAARFRSRNEPMEDIVQVGTIGLIKAIDRFDCERGVEFPTFAMPTVVGEIKRFFRDTSWSVRVPRRLQELRLALTKASDELSQKLDRSPTVAELAAVLGVSEEDVVDGLAVGNAYTASSLDSPAPEDDGGEGSLADRLGYEDTALEGVEYRESLKPLLAKLPPRERRIIMLRFFANMTQSQIGEEVGISQMHVSRLLTRTLAQLREGLISD
>NZ_CP049838.1|WP_171398160.1|4919643_4920552_+|RNA-polymerase-sigma-factor-SigF
MTVSASTAPPQQEAPPAPAPAPALEVVPEAPTEAPTEAPTEDVQPPERRRGADTRALTQLLFGELKELQPGTPEHNRVRGALIEANLPLVRYAAARFRSRNEPMEDVVQVGTIGLINAIDRFDPERGVQFPTFAMPTVIGEIKRYFRDNVRTVHVPRRLHELWVQVNSATEDLTTAFGRTPTTAEIAERLRIGEDEVLSCIEAGRSYHATSLEAAQEGDGLPGLLDRLGYEDPALDGVEHRDLVRHLLVQLPEREQRILLLRYYSNLTQSQISAELGVSQMHVSRLLARSFQRLRSANRIEA
>NZ_CP049838.1|WP_171398169.1|4933003_4934545_-|bifunctional-glycosyltransferase-family-2/GtrA-family-protein
MRTDSSPGTLPAREHLPAATAGTPVLDVVIPVYNEEKDLQPCVRRLHDHLTRTFPYSFRITIADNASTDTTPVVAQRLEARIPEVRNFRLEQKGRGRALRTVWSASDAPILAYMDVDLSTDLNALLPLVAPLISGHSDLAIGSRLARSSRVVRGPKREFISRAYNLILRGSLQARFSDAQCGFKAIRRDVAQILLPLVEDTGWFFDTEMLVLAERAGLRIHEVPVDWVDDPNSTVHIVKTATDDLKGVWRVGRALATGSLSLDRLTRPFGDDPRDRDIMDVPKGLARQLVGFCVVGGLSTLFYLLLYTVFRQFGGSQVANALALLVSAVANTAANRRLTFGVRGRGGAVKHQAQGLVVFGIGLALTSGSLFALNTATSSPAHSTELAVLIAANLAATVLRFLLFRVWVFSDRREGDEPTNGVTAAPGASAPAPGASFPHASSPTYPTGAPQTGAPQTGGPSAPLPQRHIVHPHDHNTTTQFRAGEAADGSWRDATMQMLPVRRPHDTDPGDAR
>NZ_CP049838.1|WP_171398170.1|4934559_4936185_-|HAMP-domain-containing-histidine-kinase
MSGRRRPRAQKRRAGQPRTLRTRLVVASVVLIAVVCAVIGTVTTLALRSHLYDQLGDKLKDVSSRAAGMGGPPGGIKESQPGQNTTGTSGTVDLKEFVTRGPQPQGTVIAKVVNGSISDSKVGKKDSTSTDINPMVDKDLSEAQEAALGTVAQDRSSHSIELPGLGDYLVQYVSGDKGSYYVAIPTQDTDSTITTLILVELSVTAAGLVAAGIAGYVMVGVATRPLRRVAATATRVSELPLHTGEVNLSERVPEAETDPHTEVGQVGAALNRMLNHVHGALHARQESEMRVRQFVADASHELRTPLASIRGYAELTRRGREEVGPDTRHALGRIESEAGRMTFLVEDLLLLARLDAGRPLQFEQTDLVPLVIDTISDARAAGRDHVWRLELPDEPALVSADAARLQQVLVNLLANARTHTAPGTTVTARVQRRGPWLCVDVQDNGQGIPADLLPHVFERFARGDSARSRTTGSTGLGLAIVQAVATAHGGAVTVDSVPGQTVFTVHLPALAPAVPQPSPETNWQLDSQVEHSATTWVQQGA
>NZ_CP049838.1|WP_020131327.1|4936181_4936922_-|response-regulator-transcription-factor
MTTTSPQGRTELLRPDGSPVRVLVVDDELSITELLSMALRYEGWQIRSAGDGTGAIQTAREFRPDAVVLDMMLPDMDGLTVLGRLRRELPEVPVLFLTAKDAVEDRIAGLTAGGDDYVTKPFSLEEVVARLRGLIRRSGAADRRSDSVLVVGDLTLDEDSHEVSRAGDNIHLTATEFELLRFLMRNPRRVLSKAQILDRVWSYDFGGQANVVELYISYLRRKIDAGREPMIHTRRGAGYLIKPAVS
>NZ_CP049838.1|WP_171398171.1|4937101_4937452_-|antibiotic-biosynthesis-monooxygenase
MSEQRVAPVAAFQPPYYAVVFTSLRTEGDAGYGETAERMGELVKDVPGFLGEDSARTPGGLAITVAYFRDLDGIEQWRTHTEHRAAKEYGRAHWYERYSLHIAKVEHSHGFERTPR
>NZ_CP049838.1|WP_171398172.1|4937563_4938439_-|DUF2797-domain-containing-protein
MAQAWKCAGLRWSAEGPELMWDGGRRSPLSWGKRVSFGVVEGGVRECAGARGHACPRRVVVPGRSAGGRCEECARLDRAHSVAADRVADDPRPYRVYLAWFGPGLVKVGITAVERGSVRLLEQGAVCFSWLGSGPLMAARRTEELLRAALRVPDRIPYAEKRAVRAALPQAEGERAEEMSEVYARAVELGGWPESLERAPFRPVDHVRAFGLAGAPAALGEVGQLVPGGAVSGELVAAAGPDLHLATPGGVVVLDTRLMRGWQLVPVAGGEPAFPVRHFEVGADHRQDGLF
>NZ_CP049838.1|WP_171398173.1|4938359_4938785_-|hypothetical-protein
MAGHLYDEGHTVAGWTGVGIATVGTAVVGVGVCAVSGVLLAGGLVIVGLGALVTWGLHLAGWGKPPGVRPKAEWGMRVRDPWARDGHPGCVGCRLAGRAPKALPVVSVPGPTVAGDGTGMEVRGAAVVGGGAGADVGRGAS
>NZ_CP049838.1|WP_171398174.1|4938899_4939397_+|MarR-family-transcriptional-regulator
MPAEPTPPHHGRPAATPAQALAAMDDLIAASMVGQQEMAQRLGLNVTDLTCFAYVLQAGEDLLTAGDLATRVHVTTGAVTGILNRLERAGYVTRRPDPEDRRRVRVAAIPSAVARVHALYEPYYVRLNALFADYSPQETAVLTDWFTRATTLAHTYREELRLHDS
>NZ_CP049838.1|WP_171398175.1|4939616_4939832_+|hypothetical-protein
MTAPTLVRRTAVRTTTVAVLTAGLLIVSIAGAQAADAPALGSLVPQVNNILSGLLSGNAVSSLLPNGILGG
>NZ_CP049838.1|WP_171398176.1|4940440_4940971_+|hypothetical-protein
MFQVTPLRRLAVAASAACAAVVAPSATGPVPAHATGTAEAVTAVAGVTPLTPLSPPPVREEDQVSGDHLTVTVRHAGGRADGTFEVYCHPGGGSHPDVGSACRTVDRNTRWGRDAFAPAPDGGVCTMRYGGPATAHVTGRWAGRAVDATYDRSNGCQIERWDRLVPLLPDLRPAAR
>NZ_CP049838.1|WP_171398177.1|4941309_4945881_+|PAS-domain-containing-protein
MSSRPSRGAARLAAILDALPDALLLVNANGTVVNANTIALEAFETPGTALVGRGLLDLLPQFDSKLIPGSMRRPDHMDPRGRTKPTRMVARRTDGSEFPVEVTSANLENGQQAYDGYGYSSASDELLMLVVRDLSGTVDTEAELARSQRQTEMILRAASEGVVGTDTDGRIVLVNPAAAQILGYRASDLGAKELHTLVLHSRADGSPFPYDESPLADTLRSGRKHRVRGQVLWSKSGDRVAVDLTTAPVRDGDQLVGAVMTFTDRRPYDALAEEKDGVEKRHADELEKLSEEHASDLTALRQQHVTELEELRERHEEELAAGEERYASLGEREKDRYEALAGRHEQLLTLLGESLRGPLDELRRELAALAADDAGQLWPEANQVLHHLSAGYSRITTLIDNVLGYQRLDTGSEVIARTKVMLDAVVAAGVDGAVDLIGPGRVQFAVHAPPIEAEVDARLLATALAHLVADVAGVDATGNAPVSAGGYMDNTVVVAAAQRGEVVRIEVRGPYAGGDPVHEPIVRGIVRAHGGVLQTHEVPGMSGSAYVLEVPLGGGAGAMAAPAAMALPALAAGGGAASAAPVAAMASEEDAPGEYGAGGRRRARRSSVDAFLEGDVPGVESGAEAEAAVPTGRRRRRAGAAALEETPAEVAPAVDEAEGPEGSGGTGRRRGRSAEVAVVGADAGMPAALDGGVSEGAVVTAAEHAAGTAASGTGLGGTVPPQGVPAPGGQRAPHHAPDGRQPQNALPPALPALAGAPAEAEAEDGQPTGRRRRALAAANERAAAQEAGPRAVFALPPAEADRVPDGSVGTTSTPQAPQAPQAPQTAPAASAASVARAVGPIPVPGSVPGSVPAPAPGAVQALGAVQVPAQAPVPAQAQAPVPAQAPIQAQAPVPAQAPVPAQAQAPVPAQAPVQGSAEDSAIDHGRHDAVPHDQADDHTPPQPHPTNAPTGRRRRAVAQAAEVAVPAQVQHQPQPQSQPQQVGQPAAAAAQPVPAAAPVPGQPLPGQSAAGRPLPAQVAPGQAAPNSVPNAPGQGQPLPAEAAPAPAPAVAQPAPAAATPSGGTPLPPEAAVGQPRAAQPLPAEAAAGRPMDPNSTQGRAISVRTLGQGVPFTRQAAQVQQAQQLQHAQQAQAMRHSQPGLPSAQSTATPAPNTPGGSGRRRKLGTPPDPTTRPEQTARPHPSAEQPVVAQAPAQAQAVVAPAPQPGAAPTPVAAPVPNPVPHSSLAGQSRLVPGGPGTEGAGRSYAIGAPDENAAEGPEPLDGPGGAVEVADPPRPQPLDDELPPEPLDNPRRLLVWPAPDVSTQQALSDRGYRPVIVHSREEVDAQIAAFPAALFVDPLTGPITRTALQSLRTAAVAAEVPVLVTAGLGQATREAAYGADPAVLLKALAPRDSEQHPPRVLLIEEHAEIALALTSTLERRGMQVARAASDADAVTLAGQLRPNLVVMDLMQVHRHQSGILDWLRANGQLNRTPLVVYTAAVDQADLPRLASGETVLFLAERSTSAEVQSRIVDLLARIGTN

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP049838_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049838_8

5150822-5150923

Orphan

Consensus_repeat	Method
GCTGCTGAGCTACACGTCGATGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049838_8

>merge|NZ_CP049838|8|5150822-5150923|CRISPRCasFinder
GCTGCTGAGCTACACGTCGATGAGCCGACGTGGCAGGTTCCGCCCCTGCGCCCTCCGGGTCCGAAGCCCGGCGCTCTGGCTACTGAGCTACACGTCGATGAG

>NZ_CP049838|8|6|5150822-5150923|CRISPRCasFinder
GCTGCTGAGCTACACGTCGATGAG	CCGACGTGGCAGGTTCCGCCCCTGCGCCCTCCGGGTCCGAAGCCCGGCGCTCTG
GCTACTGAGCTACACGTCGATGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049838.1\|WP_171398321.1\|5155284_5156112_+\|carbon-nitrogen-family-hydrolase	unknown	unknown	gnl\|CDD\|143607
NZ_CP049838.1\|WP_171398320.1\|5154277_5155102_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|274422
NZ_CP049838.1\|WP_171398318.1\|5152345_5153017_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP049838.1\|WP_171398323.1\|5157119_5159480_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398311.1\|5136788_5137781_+\|NAD(P)H-quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|176180
NZ_CP049838.1\|WP_171398317.1\|5151035_5152349_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|349949
NZ_CP049838.1\|WP_171398316.1\|5148443_5150765_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398319.1\|5153297_5154200_+\|D-alanyl-D-alanine-carboxypeptidase	unknown	unknown	gnl\|CDD\|224600
NZ_CP049838.1\|WP_171402122.1\|5141127_5142699_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP049838.1\|WP_171402121.1\|5138506_5139052_+\|bacterial-proteasome-activator-family-protein	unknown	unknown	gnl\|CDD\|378489
NZ_CP049838.1\|WP_171398315.1\|5146839_5148384_+\|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl\|CDD\|237001
NZ_CP049838.1\|WP_171402123.1\|5142774_5144001_-\|phosphotransferase	unknown	unknown	gnl\|CDD\|270702
NZ_CP049838.1\|WP_171398325.1\|5160519_5160864_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_054242050.1\|5160947_5161196_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398324.1\|5159640_5160357_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398322.1\|5156148_5156643_-\|LURP-one-related-family-protein	unknown	unknown	gnl\|CDD\|367978
NZ_CP049838.1\|WP_171398313.1\|5144611_5145835_+\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	unknown	unknown	gnl\|CDD\|213783
NZ_CP049838.1\|WP_171402120.1\|5137794_5138313_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP049838.1\|WP_171398312.1\|5139137_5140772_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP049838.1\|WP_171398314.1\|5145836_5146829_+\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101

Protein	Function_ID	Function_description	E-value
NZ_CP049838.1\|WP_171398321.1\|5155284_5156112_+\|carbon-nitrogen-family-hydrolase	gnl\|CDD\|143607	cd07583, nitrilase_5, Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases). The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.	1.29498e-121
NZ_CP049838.1\|WP_171398320.1\|5154277_5155102_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	3.70836e-24
NZ_CP049838.1\|WP_171398311.1\|5136788_5137781_+\|NAD(P)H-quinone-oxidoreductase	gnl\|CDD\|176180	cd05276, p53_inducible_oxidoreductase, PIG3 p53-inducible quinone oxidoreductase. PIG3 p53-inducible quinone oxidoreductase, a medium chain dehydrogenase/reductase family member, acts in the apoptotic pathway. PIG3 reduces ortho-quinones, but its apoptotic activity has been attributed to oxidative stress generation, since overexpression of PIG3 accumulates reactive oxygen species. PIG3 resembles the MDR family member quinone reductases, which catalyze the reduction of quinone to hydroxyquinone. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	0
NZ_CP049838.1\|WP_171398317.1\|5151035_5152349_-\|MFS-transporter	gnl\|CDD\|349949	cd06174, MFS, Major Facilitator Superfamily. The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.	4.23436e-34
NZ_CP049838.1\|WP_171398319.1\|5153297_5154200_+\|D-alanyl-D-alanine-carboxypeptidase	gnl\|CDD\|224600	COG1686, DacC, D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane].	1.35048e-51
NZ_CP049838.1\|WP_171402122.1\|5141127_5142699_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.75526e-120
NZ_CP049838.1\|WP_171402121.1\|5138506_5139052_+\|bacterial-proteasome-activator-family-protein	gnl\|CDD\|378489	pfam10759, DUF2587, Protein of unknown function (DUF2587). This is a bacterial family of proteins with no known function.	6.33495e-91
NZ_CP049838.1\|WP_171398315.1\|5146839_5148384_+\|2-oxo-acid-dehydrogenase-subunit-E2	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	5.82314e-153
NZ_CP049838.1\|WP_171398313.1\|5144611_5145835_+\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	gnl\|CDD\|213783	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	0
NZ_CP049838.1\|WP_171402123.1\|5142774_5144001_-\|phosphotransferase	gnl\|CDD\|270702	cd05153, HomoserineK_II, Type II Homoserine Kinase. This subfamily is composed of unusual homoserine kinases, from a subset of bacteria, which have a Protein Kinase fold. These proteins do not bear any similarity to the GHMP family homoserine kinases present in most bacteria and eukaryotes. Homoserine kinase catalyzes the transfer of the gamma-phosphoryl group from ATP to L-homoserine producing L-homoserine phosphate, an intermediate in the production of the amino acids threonine, methionine, and isoleucine. The Type II homoserine kinase subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	8.25869e-21
NZ_CP049838.1\|WP_171398322.1\|5156148_5156643_-\|LURP-one-related-family-protein	gnl\|CDD\|367978	pfam04525, LOR, LURP-one-related. The structure of this family has been solved. It comprises a 12-stranded beta barrel with a central C-terminal alpha helix. This helix is thought to be a transmembrane helix. It is structurally similar to the C-terminal domain of the Tubby protein. In plants it plays a role in defense against pathogens.	3.67574e-31
NZ_CP049838.1\|WP_171398318.1\|5152345_5153017_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	1.10545e-44
NZ_CP049838.1\|WP_171402120.1\|5137794_5138313_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0.000424112
NZ_CP049838.1\|WP_171398312.1\|5139137_5140772_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.58394e-122
NZ_CP049838.1\|WP_171398314.1\|5145836_5146829_+\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	4.85787e-161

>NZ_CP049838.1|WP_171398316.1|5148443_5150765_-|hypothetical-protein
MNDDADQQHLAEANPGYASGQLARALRTALTHEDPDTRRRAGERQRAWRSVLAGMANGLLTIGSRTPVRDLPAWVTPEVIRGGFATGAPSAGGPLTEYEAEAACRAGVPPDRQALFAYWLSEDGLAQLYELLDGGRYEVTVPEEAALLTVAWLARAGETDAALGLVEELAPFAERLRFTPRPSTRPAPDAGTVHRRTVAEAGESLARRRTSEAVETQREALAVWQPFGDELLAHWLETADAGQPARVLTRAPDAAWHGRGAELLCRYRDLAGRHTHCTKHLKPKENLGILRGALEETVAGRELDARRLGLLRHAVTSMVRRRGLPGSTELTALRREQAAQAALPSHHALAQLVLRRLSGLDQQAGVADVAPLVAAVGEEEARETGLPVGAVIPAGVRRPVEAALSAPLSTLVERGVVPSAEVLAELVPRLVAATTAQAYPDPALRTLAAAHHRAFAGRRSLLLLNLQRQVRAEELPWVRAVAGQRTDGEAGAVSAVALRQLGELAVQAFPGTILPNSLIRELSVLARQAELGAPLVEELAADIFMGTFTPKFLAAARIAAELLGGGSLYERYYAIDYRAVRNLAIVEAGEALTRSYGARTSPGFAKLCVARAEAGSSRSRRGGGSVAANGKVIEQAQILTTHNLATLVHRVGIDPAVGWADLARRCFVTVCRLTGRVHGNPRPLSTIKDVAYAWRQLVFHLSLCTPGERARTLAGLSEELTRHPGHVAGRLAPALTGLYQVAEGGRADEGTGRLLLGWTTDGHWLRPDPASAG
>NZ_CP049838.1|WP_171398315.1|5146839_5148384_+|2-oxo-acid-dehydrogenase-subunit-E2
MTTMTEASVREFKMPDVGEGLTEAEILKWYVQPGDTVTDGQVVCEVETAKAAVELPIPYDGVVRALHFPEGTTVDVGMSIIAVDVSGGAGDAPVAAPVAEVPAQAAVQPPAQAPAAPEKKPEAAQAEAPQAEAPQAAAPQAAAPQAEAAKPVGSGRQPVLVGYGVAASSTKRRPRKGPETAVSQVPDTIQAELNGHGGAPAVRERPLAKPPVRKLAKDLGVDLATVVPSGPDGIITREDVHAAVAPAAPATQAAPVAEPAPQVTQAPVTTPAAVPVPSYDTARETRVPVKGVRKATAAAMVGSAFTAPHVTEFVTIDVTRTLKLVEELKQDKDMQGLRVNPLLLIARALLVAVKRNPEINASWDEAAQEIVVKHYVNLGIAAATPRGLLVPNIKDAHAKTLPQLAESLGELVSTAREGRTSPAAMQGGTVTITNVGVFGVDTGTPILNPGESAILAIGAIKLQPWVHKGKVKPRQVTTLALSFDHRLVDGELGSKVLADVAAILEQPKKLITWG
>NZ_CP049838.1|WP_171398314.1|5145836_5146829_+|alpha-ketoacid-dehydrogenase-subunit-beta
MAETVTSKNLALAKAINESLRRALETDPKVLIMGEDVGKLGGVFRVTDGLQKDFGESRVIDTPLAESGIVGTAIGLALRGYRPVVEIQFDGFVFPAYDQIVTQLAKMHARSLGKVKLPVVVRIPYGGGIGAVEHHSESPEALFAHVSGLKIVSPSNASDAYWMMQQAIQSDDPVIFFEPKRRYWDKGEVNPEAIPGPLHKARVVREGTDLTLVAYGPMVKLCQEVAAAAAEEGKNLEVLDLRSVSPMDFDAIQASVEKTRRLVVVHEAPVFFGSGAEIAARITERCFYHLEAPVLRVGGYHAPYPPARLEEEYLPGLDRVLDAVDRALAY
>NZ_CP049838.1|WP_171398313.1|5144611_5145835_+|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha
MTVESTAARKPRRSAGSKAGTTSTERTTRTTARKSAEPELVQLLTPEGKRVKNAKNAEYAKYVAGVTPEELRGLYRDMVLTRRFDAEATALQRQGELGLWASLLGQEAAQIGSGRALRDDDYVFPTYREHGVAWCRGVDPTNLLGMFRGVNNGGWDPNGNNFHLYTIVIGSQTLHATGYAMGVAKDGADSAVIAYFGDGASSQGDVAESFTFSAVYNAPVVFFCQNNQWAISEPTEKQTRVPLYQRAQGYGFPGVRVDGNDVLACLAVTRWALDRARDGEGPTLVEAYTYRMGAHTTSDDPTKYRADEEREAWEAKDPILRLRRHLEASNHTDEGFFAELEVESEALGRRVREAVRAMPDPDRFAIFENVYADGHALVDEERAQFAAYQASFVTESDSGFAAGSGGN
>NZ_CP049838.1|WP_171402123.1|5142774_5144001_-|phosphotransferase
MLHAPPLGALLRRYAAGTALTCEPVDEGLLNRGYRLRTTRGRYFLKHHFDPDTADPASIARQHRATERLADLGVPVAPPLPGHDGRTVAVVGGHAYALHPWIDGRHRHGAQLTPGQCGRLGALLGVVHASLEHVMRAAHAEHLPPGRGGHVPRGLGVNAPQARDPERDPEHAPERAPARRTTPPERPARATAAVPAEHTSPAERTTHVETTTHVETTVPAPSPDPADTFVLIDDLLARVRRHRPADSFDELARHRLLERRTLLERHADRRPPHSGPVGWVHGDFHPFNLLYRGDAPAAIVDWDRLGVQPRAEEAVRAAAIFFVRPDGSLDLPKAREYARAYRRAAGATPSELTAAVHRVWWERLNDFWMLRWHYERGDTRADSQFPAASALAVWWTREYDAVCGAFAD
>NZ_CP049838.1|WP_171402122.1|5141127_5142699_+|serine/threonine-protein-kinase
MMAQQRAQGPSDPEATGGGMSDAPENWGNGGLVGDGRYRLTHRLGRGGMAEVFAAEDVRLGRTVAVKLLRADLAEDPVSKARFTREAQSVAGLNHHAIVAVYDSGEDFVGGQSVPYIVMEIVEGRTIRDLLLNAEAPGPEQALIITSGVLEALAYSHQHGIVHRDIKPANVIITHNGAVKVMDFGIARALHGASTTMTQTGMVMGTPQYLSPEQALGKAVDYRSDLYATGCLLYELLALRPPFTGETPLSVVYQHVQDIPVPPSQTSDGVCPPELDGLVMRSLAKDPDDRFQTAEEMRGLVQYGLQMLYDQGGHTGTWNTGPVGAHDGRGTPAGGFASTTALAHGADGSSTSQIPQPILPTGYGGGDDGGFEGHGNKGSGRGKLWILAVFAVIAIAAGVALALNGQGKGSGDTDTSPSPSTSQSATDDASTATPSDEATDTSTDDTSDDNSGSNSDSNWTPSYSPSYSPSYSPSESASSEPTDEETETQPSDDPTDTQPSDDPTDVEPSDPATEGGTLGSIGN
>NZ_CP049838.1|WP_171398312.1|5139137_5140772_-|protein-kinase
MSQDGAQGRYAGRALAAGRYQLRDLLGEGGMASVHLAYDAVLDRQVAVKTLHTELGREQAFRERFRREAQAVAKLTHTNIVSVFDTGEDDVEGLTTPYIVMEYIEGRPLGSVLDEDVRQQGAMPADKALKITADVLAALEISHEMGLVHRDIKPGNVMMTKRGVVKVMDFGIARAMQSGVTSMTQTGMVVGTPQYLSPEQALGRAVDARSDLYSVGIMLFQLVTGRLPFEADSPLAIAYAHVQEEPVAPSSVNRALPPAVDALIARALKKNPNERFPTAVAMRDECLRVAASFHAAPPSIVPGAHTSSGAGVGSAVFPPVGQSTPPPQAGVQTPYQPAPTPNPYGTPTPSASYGYPQQGYQTPAPAYGHQQAPHTPPAYNLSPQPSTAVSSGGGGRRNSKAVLIGSAVVAVVAVGGLIASLAVSGGDDDDAKGGTTSSSPSATKAADYRAPDTSKTIESTECSEPQESYNDPDKIRVPNFKFKYIGSVKECFQAAGWPYKITKVDENTYGDGAVMDQFPSAGTDVDPKDMPEIEIKVSTGNPAS
>NZ_CP049838.1|WP_171402121.1|5138506_5139052_+|bacterial-proteasome-activator-family-protein
MEMPRNERSPENAQKILVVGQDGMALGDIDADDDSREIPVTEQVEQPAKVMRIGSMIKQLLEEVRAAPLDEASRVRLKEIHSSSVKELEDGLAPELVEELERLSLPFNEDSTPSDAELRIAQAQLVGWLEGLFHGIQTTLFAQQMAARAQLEQMRRALPPGVSHEGVDDPRAGGRSGGPYL
>NZ_CP049838.1|WP_171402120.1|5137794_5138313_-|hypothetical-protein
MRSGVGVGVGVLGVLVLPYGGVSSYAAVSSYAPVSASATPAPSPSSSEPDRAGSRAGEGRQRPGRAGDHAEEEADEEADGDAQDTEGEDGTGEDAGEGSGDGDLSDDTAASESPEAAAPVPSGAPRDAARRPVAQPEGSDGPVLQILPLGSGLVLIGLGIALALAALRLRRT
>NZ_CP049838.1|WP_171398311.1|5136788_5137781_+|NAD(P)H-quinone-oxidoreductase
MHAITIPEPGGPEALVWDEVPDPVPGAGEVLVEVVAGAVNRADILQRQGFYDPPPGASRYPGLECSGRIVEVGPGVSGWAVGDEVCALLAGGGYAEKVAVPAGQLLPVPDGVDLRRAAALPEVTSTVWSNVFMIAHLRPGETLLVHGGSSGIGTMAIQLAKAVGARVAVTAGTKEKLDQCAELGADILINYREQDFVAELKQATDGAGADVILDNMGAKYLDRNVQALAVNGRLAIIGMQGGIKAELNIGALLGKRAAISATSLRARPLGEKTAIVAAVREHVWPLLAAGHVRPVVDREVPMSDAAEAHRIVEASSHVGKVLLVTPEGRP
>NZ_CP049838.1|WP_171398317.1|5151035_5152349_-|MFS-transporter
MSAGSPSVNSTLPGDPPGGRRAMAVWGIGVSVYFVAVIFRTSLGVAGLDAAERFQVNASALSTFSILQLLVYAGMQIPVGLLVDRLGTKKVLTIGVVLFTAGQLGFAFSPSYGTALASRALLGCGDAMTFISVLRLGSRWFPARRGPMVAQLAGLAGMAGNLVSTLVLARLLHGIGWTAAFAGSAAAGVVVLVLLLLFLKDHPEGHEPEPFPHRGAAYVRRQIAASWREPGTRLGLWVHFTTQFPAMVFLLLWGLPFLVEAQGLSRATAGELLTLVVLSNMVVGLIYGQVVARHHEARLPLALSTVGATALMWAATLAYPGDRAPMWLLVALCAVLGACGPASMLGFDFARPANPPERQGTASGITNMGGFVASMTTLFAVGVLLDATGDDYTIAFSCVFVLQALGVSQILRLRSRAARRERERLVASRVETVHVPA
>NZ_CP049838.1|WP_171398318.1|5152345_5153017_-|GntR-family-transcriptional-regulator
MPSSAPPAPAPVKQPPAADRVYAHIKQGVLDRRYEGGALLTEGELAEAVGVSRTPVREALLRLEVEGLIKLYPKKGALVLPVSAQEIADVVETRLLVEEHAARKAVPASAALIERLEELLAKQKAQAAAGDLAAAAVTDRCFHAEIVRSGGNDILSRLYDQLRDRQLRMGVAVMHSHPDRIAKTLGEHEEILQALRSGDAEAAVEIVHRHVGWFSHLARGEVR
>NZ_CP049838.1|WP_171398319.1|5153297_5154200_+|D-alanyl-D-alanine-carboxypeptidase
MITATKGIRVRRAASVAVTVGAVLATGALTAAPAQAVTTPTITAKGGYLMNSATGATLYSKAADTRRLTASTTKVMTAKVVLSQANLNLDAKVTISKAVSDYMVAEGYPSSAKLIVGDKLTVRQLLYGMMLPSGCDAAMALADKFGTGTTVAARTKNFISKMNTTAKALGMTNTHFDSFDGLSNGANYSTPRDLTKLARSVMKSSTFKTVVKAKSYTAKTITKTGATRTMSAWTNTNTLLGWNGTLGVKTGSGTQAKYCLIFAATLNGESVMGTVLTSPDAANRTADVKKLINYGYAKIS
>NZ_CP049838.1|WP_171398320.1|5154277_5155102_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MSLHPTLQPYADAWTHSIEAISELVLPLVEADWNRRTPCPGWSVRDIVSHVIGLDCEMYGDPRPIHTLPRDLYHVTNDIQRYMEMQVDVRRHHTAPEMTSELEYTVIRRNRQLRNETRQPTTMVRGPLGTELTLEESMRKHAFNVWAHEQDLRAALGRPGNLDSPGAHIARDALLAELPAVVAEKADAPRSSAVVFDVHGPIEFLRTIRVDIQGRGTLETAPALGPAAAFTLDWETYVRLACGRVTAEAVADRVKAEGDPELTAAILRNFAVTR
>NZ_CP049838.1|WP_171398321.1|5155284_5156112_+|carbon-nitrogen-family-hydrolase
MRASLIQIAVEEGESVESRRVRVAALVREQAGAADLVVLPELWTTGAFAYEEFGSEAEPLEGPTYEAMAKAASDAGVWLHAGSIPERAPSGDSAAGEGPLYNTSLVFSPSGELAAAYRKIHRFGFDKGEAVLMGAGEELVTVRLPGTTVGVATCYDLRFPELFRGLVDAGAETLVIPAGWPERRRAHWTLLARARAVENQAFVLACGTAGTHAGVPQAGHSIVVDPWGEVLAEAGSGEEVLTVEFDPSRVATTREQFPALKDRVLGLRTPERRQP
>NZ_CP049838.1|WP_171398322.1|5156148_5156643_-|LURP-one-related-family-protein
MRFLVRDRLLGFGDDYWIEDDHGNKVYLVDGKAMRLRDTFELKDTHGRVLIDIHQKMFALRDTMVIERDGEPLATIRRKRLSLLRNHYRVALADGRTELDVSGKILDREFAVEYDGELLAVVSRRWLHVRETYGVDVVREDADPALLIAVAVCVIHLADKERED
>NZ_CP049838.1|WP_171398323.1|5157119_5159480_-|hypothetical-protein
MPLHSPRSLTVQWGSDSVLVSNIEPTLPGSPGERDIAKVVEAGNANPATPLPDAAWQAVARSTTGPDGLAVQLRSTEEEPNGLLMVENVEGATLRSVVTRVRLNEMLPGIQPRTGMEVMEIADPQVQGITSEGRPCAVIGYRYKDLQHLRDHMWQTIHGTLSLNSYAASILARGVTRNVITHPVEITFEDGTDPLYSLVVRDGITRMASSWAVLAGPGAEPAEAATLAVDSLLGKPGAAPTTGSSPLGERLAASRERWRQGLREEFAQEMAAPEPGVRAAQIAQTFVLPAQIAVGAEGHPDHLLASEDIFDDAIRSVLASVHVEFKQWDTAAQNVEVATRALKRVIQLGDAQVRKSDLQVVYGLAVGRITVEELPQVFAGDPPGTALWRGVYLVHALSRPELLERLKDQAKAIKGGRRMGLKGFAELLGPLIDLPWRSRKKLVTAQARNAWNNGGVLTADVVGEWEPHPTGDFTSLVAPALAGDIDARCTLAVAGGMALIADKLLTRNVGSALSAPREKGGVPFRADVSLVIEGLSEEGNELGLWTLALAADRFRSDDLPENAVTMRQLTRKEKSQDGTDTPYVHFKVDLEAEDKIARDADGVPVTLHQWDVVWASDPARALKAHPPRTVVVPQQYVPVPPEPGATGTSTGPGAGVAATEGTGTEQTDAADHGSDTDQADSTRSPWGAVPPPLLSRPASQRAADHRHVLRQSVTAARDALDHLHALEPEVGGHTPIVPLSVLDELHELLIGLQTDVENLRRRTVRGGEPSAEGEETDEESQEAAGV
>NZ_CP049838.1|WP_171398324.1|5159640_5160357_-|hypothetical-protein
MDADENRSIKFANANLHNALYLGVLSGDRDVSVVGWLRTTPDALSKAAAAWGEFRQGLHADPALNIRPHDRLRARKLAAGQGRSRGTSGRPGPSKAEKWSYRYVLRRGIDVIAALPGTTVGTACGHGLHATATTDALLKTLARRQAVEETTALAVIRMSSAVTAYHRLTPGLEPTSLDALPYGTAEVDSLLEPAEFVAYCAYRHWARLHNRRLLPNWFPELLPGADGPLEFGSEAASR
>NZ_CP049838.1|WP_171398325.1|5160519_5160864_-|hypothetical-protein
MNFTVIAHAVEVDHGIKRLSMRFIKKYAAPERSRLSTELCEQITEAFDDLGLITLPRRLPTSENEFVFVIAKASPLGQVIDVATSLVLLDRLGQNPLPRLFENYPEARAQLTVN
>NZ_CP049838.1|WP_054242050.1|5160947_5161196_-|hypothetical-protein
MGLGGCIILIAVGAILTFATDWDMQGVNLDLVGVILMIVGLIGVTTFSSIARRRRVMVPPTSTTVVETERHQRDGYNGGYGV

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP049838_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049838_9

5175901-5175995

Orphan

Consensus_repeat	Method
TGGGACAACCGGCCTCGGCGGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049838_9

>merge|NZ_CP049838|9|5175901-5175995|CRISPRCasFinder
TGGGACAACCGGCCTCGGCGGTGCGTGGGGCGGCGGTGGGACAACCGGCCTCGGCGGTGCGTGGGGCGGCGGTGGGACAACCGGCCTCGGCGGTG

>NZ_CP049838|9|7|5175901-5175995|CRISPRCasFinder
TGGGACAACCGGCCTCGGCGGTG	CGTGGGGCGGCGGTGGGACAACCGGCCTCGGCGGTGCGTGGGGCGGCGG
TGGGACAACCGGCCTCGGCGGTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049838.1\|WP_171402125.1\|5184422_5185667_+\|polysaccharide-lyase-family-1-protein	unknown	unknown	gnl\|CDD\|214765
NZ_CP049838.1\|WP_171398326.1\|5161289_5162612_-\|M18-family-aminopeptidase	unknown	unknown	gnl\|CDD\|235073
NZ_CP049838.1\|WP_171398342.1\|5185729_5186221_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398338.1\|5179096_5179612_-\|toxin-antitoxin-system-HicB-family-antitoxin	unknown	unknown	gnl\|CDD\|310261
NZ_CP049838.1\|WP_171398329.1\|5166604_5167534_-\|Bro-N-domain-containing-protein	unknown	unknown	gnl\|CDD\|376797
NZ_CP049838.1\|WP_171398336.1\|5177044_5178061_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|130256
NZ_CP049838.1\|WP_171398341.1\|5181877_5182690_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398337.1\|5178121_5178970_-\|DUF4097-family-beta-strand-repeat-protein	unknown	unknown	gnl\|CDD\|372574
NZ_CP049838.1\|WP_171402124.1\|5182694_5184158_-\|FG-GAP-repeat-protein	unknown	unknown	gnl\|CDD\|214549
NZ_CP049838.1\|WP_171398328.1\|5165542_5166514_+\|pirin-family-protein	unknown	unknown	gnl\|CDD\|224655
NZ_CP049838.1\|WP_171398339.1\|5180079_5181117_+\|dioxygenase	unknown	unknown	gnl\|CDD\|239540
NZ_CP049838.1\|WP_171398334.1\|5174059_5175427_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340877
NZ_CP049838.1\|WP_171398333.1\|5172904_5173882_+\|intradiol-ring-cleavage-dioxygenase	unknown	unknown	gnl\|CDD\|239540
NZ_CP049838.1\|WP_171398331.1\|5168722_5170864_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP049838.1\|WP_171398327.1\|5162732_5164574_-\|acyl-CoA-dehydrogenase-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|173842
NZ_CP049838.1\|WP_171398330.1\|5167706_5168759_+\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP049838.1\|WP_171398340.1\|5181160_5181838_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171394949.1\|5176256_5177048_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|366444
NZ_CP049838.1\|WP_171398332.1\|5171008_5172772_+\|aspartate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234775
NZ_CP049838.1\|WP_028806966.1\|5164781_5165264_+\|SseB-family-protein	unknown	unknown	gnl\|CDD\|377787

Protein	Function_ID	Function_description	E-value
NZ_CP049838.1\|WP_171402125.1\|5184422_5185667_+\|polysaccharide-lyase-family-1-protein	gnl\|CDD\|214765	smart00656, Amb_all, Amb_all domain.	1.51031e-50
NZ_CP049838.1\|WP_171398326.1\|5161289_5162612_-\|M18-family-aminopeptidase	gnl\|CDD\|235073	PRK02813, PRK02813, putative aminopeptidase 2; Provisional.	0
NZ_CP049838.1\|WP_171398338.1\|5179096_5179612_-\|toxin-antitoxin-system-HicB-family-antitoxin	gnl\|CDD\|310261	pfam05534, HicB, HicB family. This family consists of several bacterial HicB related proteins. The function of HicB is unknown although it is thought to be involved in pilus formation. It has been speculated that HicB performs a function antagonistic to that of pili and yet is necessary for invasion of certain niches.	0.00120941
NZ_CP049838.1\|WP_171398329.1\|5166604_5167534_-\|Bro-N-domain-containing-protein	gnl\|CDD\|376797	pfam02498, Bro-N, BRO family, N-terminal domain. This family includes the N-terminus of baculovirus BRO and ALI motif proteins. The function of BRO proteins is unknown. It has been suggested that BRO-A and BRO-C are DNA binding proteins that influence host DNA replication and/or transcription. This Pfam domain does not include the characteristic invariant alanine, leucine, isoleucine motif of the ALI proteins.	3.89255e-18
NZ_CP049838.1\|WP_171398336.1\|5177044_5178061_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|130256	TIGR01188, drrA, daunorubicin resistance ABC transporter ATP-binding subunit. This model describes daunorubicin resistance ABC transporter, ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	6.66072e-113
NZ_CP049838.1\|WP_171398337.1\|5178121_5178970_-\|DUF4097-family-beta-strand-repeat-protein	gnl\|CDD\|372574	pfam13349, DUF4097, Putative adhesin. This has a putative all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif. It may form part of a bacterial adhesin.	0.000176815
NZ_CP049838.1\|WP_171398328.1\|5165542_5166514_+\|pirin-family-protein	gnl\|CDD\|224655	COG1741, COG1741, Pirin-related protein [General function prediction only].	2.38838e-66
NZ_CP049838.1\|WP_171398339.1\|5180079_5181117_+\|dioxygenase	gnl\|CDD\|239540	cd03457, intradiol_dioxygenase_like, Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the extradiol-cleaving enzymes which break the C2-C3 or C1-C6 bond and utilize Fe2+ and Mn+. The family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases. The specific function of this subgroup is unknown.	7.17673e-77
NZ_CP049838.1\|WP_171398334.1\|5174059_5175427_+\|MFS-transporter	gnl\|CDD\|340877	cd17319, MFS_ExuT_GudP_like, Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily. This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.896e-89
NZ_CP049838.1\|WP_171398333.1\|5172904_5173882_+\|intradiol-ring-cleavage-dioxygenase	gnl\|CDD\|239540	cd03457, intradiol_dioxygenase_like, Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the extradiol-cleaving enzymes which break the C2-C3 or C1-C6 bond and utilize Fe2+ and Mn+. The family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases. The specific function of this subgroup is unknown.	9.91016e-75
NZ_CP049838.1\|WP_171398331.1\|5168722_5170864_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	3.14342e-49
NZ_CP049838.1\|WP_171398327.1\|5162732_5164574_-\|acyl-CoA-dehydrogenase-C-terminal-domain-containing-protein	gnl\|CDD\|173842	cd01153, ACAD_fadE5, Putative acyl-CoA dehydrogenases similar to fadE5. Putative acyl-CoA dehydrogenase (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	0
NZ_CP049838.1\|WP_171398330.1\|5167706_5168759_+\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	1.20655e-45
NZ_CP049838.1\|WP_171402124.1\|5182694_5184158_-\|FG-GAP-repeat-protein	gnl\|CDD\|214549	smart00191, Int_alpha, Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.	0.000584167
NZ_CP049838.1\|WP_171394949.1\|5176256_5177048_-\|ABC-transporter-permease	gnl\|CDD\|366444	pfam01061, ABC2_membrane, ABC-2 type transporter.	5.15666e-16
NZ_CP049838.1\|WP_171398332.1\|5171008_5172772_+\|aspartate--tRNA-ligase	gnl\|CDD\|234775	PRK00476, aspS, aspartyl-tRNA synthetase; Validated.	0
NZ_CP049838.1\|WP_028806966.1\|5164781_5165264_+\|SseB-family-protein	gnl\|CDD\|377787	pfam07179, SseB, SseB protein N-terminal domain. This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon. This entry contains the presumed N-terminal domain of SseB.	5.63469e-05

>NZ_CP049838.1|WP_171398334.1|5174059_5175427_+|MFS-transporter
MSEPESGAEAGAESRAVGKFLRRMMPILVLMLLVNNLDRTNVGFVQDELQADVGISATAYGLGAGLFFIGYALFEVPSNMLLERFGARVWLTRIMITWGLVIVAMCFIHDVTTFYTLRFLLGVAEAGFFPGAMLYITQWLPDASRGRATAIFLGGSAAAGIVTGPVTGALLELHGAGGVAGWRWMFGLEGVFSVVVGIVAGFFLVSRIEDARWLTREEKDALGAAVAEDREARSRAPHMSRFKLLFHPQVALLTGAFFAMTLTGYAITFWLPSLIEDIGGLSSFQVGLLSAIPAVCSMIAMYSMSHFTDRAPDRRPYLAITLVLSATGTYLATLGSPWFGLAAITLAGVGSKCAATLFWPMAQSGLDLRIAAPGLALVNSIGNLGGFFSPTLFGYLKDTTGSTNGGLYTLSAASLLAVVAARFIRSARAASDPLLGTSPEAHRKPEGGAQRRVVS
>NZ_CP049838.1|WP_171398333.1|5172904_5173882_+|intradiol-ring-cleavage-dioxygenase
MTGSQKPHSEQDLSRRKVVAVAAGGIAAAGLGGTAFAASAADGHGRPAPAGADTDGEVCYRLTSETVEGPYYIDADKIRRDVTEDRAGIPLLLGLKVIDSETCRPIRNAAVDIWHCDAAGVYSGYEDQGNGGGGGPAPTGEPPTGEPPTGAPTGAPPGGGHQEPTDDSRYLRGTWRTDRHGQVAFRTVFPGWYRGRCVHIHVKVHVDGEWTDAGYEGGHTCHTGQFFFDEESVLASAVVEPYASNAAERTTLTEDTIYDQSGTQGGLLKLRYDKRDIARGVHGSITVGVDPDATEDGQGAPPQPSASASASDSASASASPSVSDS
>NZ_CP049838.1|WP_171398332.1|5171008_5172772_+|aspartate--tRNA-ligase
MHRYRSHTCGELRASDVGTDVRLSGWLHNRRDLGGILFIDLRDHYGITQLVARPGTPAYEALDRLTKESTVRIDGKVVSRGSENVNADLPTGEIEVEVGEVELLGAAQPLPFTINAEDGVNEERRLEYRFLDLRRERMHRNIMLRTSVISAMRHKMTALGFNEMATPILSATSPEGARDFVVPSRLHAGRFYALPQAPQQFKQLLMISGFDRYFQIAPCFRDEDARADRSPGEFYQLDVEMSFVEQEDVFQPIEKLMTELFEEFGGGRHVTSPFPRIPFRESMLKYGSDKPDLRAQLELFDITDIFEGSEFKAFAGKHVRALPVPDVSAQPRKFFDQLGDFAVTLGAKGLAWVRVAEDGSLTGPIAKFLTEENVAELTKRLSLVAGHAVFFGAGEFDEVSKIMGAVRVEAAKRAGHFEENVFRFCWIVDFPMYEKDEETGKIDFSHNPFSMPQGGLEALETQDPLDILGWQYDIVCNGVELSSGAIRNHEPEIMLKAFEIAGYDHETVEEKFAGMLRAFRFGAPPHGGIAPGVDRIVMLLADEPNIRETIAFPLNGNAQDLMMGAPTELEEARLRELHLSVRKPQPK
>NZ_CP049838.1|WP_171398331.1|5168722_5170864_-|SpoIIE-family-protein-phosphatase
MRTGEPLPAVGEVLASLATGLWHWDTATGLVTVDAEAARLLGLPQEETVLTEAQTRARLHPVDWNEITGVIQLAVAEGTLAEVRIRIMDYRGRVVRVVRSRSRPSFDPVKKAYELIGTLQEVTEPTPGTPAGRTAVTGDWRRSREAFLLDAGRALAEARSTEEVLRVAAALSMPGFSPDGLAVFGVEGERLTIIGHHGHPSGDEDPFSHMSIHTDYPAAEVVRTGRAVYLSSPERYMERYPLTWPLAAHFGRHSWAFLPLTVAGRTMGAWMAAFAYPVAFTPDERSVLTTVARMLAQALTRAGLAETQRELTDGLQRSMLPTLGPEIPGMTLAARYIPTGGGLQVGGDWYDMIPLPRGRFALVIGDVQGHDVRAAGLMGQLRIAVRAYAAEGHRPDAVLSRASGFFHGLTDTDGGAGADPRFATCLYIEVDPVTGVLEAARAGHLDPTIRMSDGTVLVRATAGGLPLGIDPDADYPTTRLALEPGEALMLCTDGLLETGGHDLDTGWRRVRKILEAHEGDLEELADALVQAVHGPSSHHTTGPLADRREDDIAVLLLCRQDEGGCGPGAAPVPVRRPVRRSMLTVAQAEPERIAVARQQLRDLLHDWTCEDQIDSAVLLVSETLTNVLVHTDADALLVAEVTGAPGERRLRIEVTDAGDDLPHMRRPGELASSGRGLVLIELLADTWGVAPRGEGKSIWFELYEFGEPSAGAP
>NZ_CP049838.1|WP_171398330.1|5167706_5168759_+|AI-2E-family-transporter
MHLLPLPARRFAAWCAVILLAAGVGYVGIRLCAELRTAVTPVLLALLGTALLRPLFRRLVEVGVPRSVSAGVTCVAVVAVVGGAVYIVVAALIDSGDQIVAALRSAARGIAEHFGAAGTSLDDLASNAKELLTKFGGTAASNVISGVSVVGESIAMAVLALLLVFFFLRDSHRAIGALRSVAPRGTGDTLEAMARRAFRAVEGFMRGTTFIAFIDAVCITVGLLVLDVPGAVGLGALVFVGAYIPYLGAFLSGAVAVLVALADRGFVIALWALGVVLAVQVLEGHVLQPMIQSRTVQMHPAVVMVAITAGASVAGILGMLLAVPVTAAAFGVLHELRTRHGAPAEGSPNS
>NZ_CP049838.1|WP_171398329.1|5166604_5167534_-|Bro-N-domain-containing-protein
MYEQNNTQPPDRSAAQQDAIDINDFVFAATGARVRRLTTPGGEHWFPAVDVAAQLGYANTRDALRQSVAEQHTTSLDDLARSVGTADASCNIAGHRLKKSMKMVNLQGLIQLVNGCTKPEAQPFKTWVAGVIATLQRDGSYSLEPAPVQPAPAVGTAYVMPEQVVEAIVRLEERNLYADEMLAAAAGERNDLLRQITDSQNRMADALRDIAEALRRPSHSAPAPGLTAQQLLDTWKKRHLLVTDDVHTVAAVLAPALARGEARYHVEEIAARTGMSQDRVHDCLRMLLKRGCMRQTGCSADGAPVYVLP
>NZ_CP049838.1|WP_171398328.1|5165542_5166514_+|pirin-family-protein
MPAVTVENPLTLPRVTASADAVARPVLTVTTAPSGFEGEGFPVRRAFAGINYRHLDPFIMMDQMGEVEYAPGEPKGTPWHPHRGFETVTYIIDGIFDHQDSQGGGGTITNGDTQWMTAGSGLLHIEAPPESLVMSGGLFHGLQLWVNLPARDKMMAPRYQDIRGGHVQLLTSPDGGALLRVIAGELDGHAGPGITHTPITMVHATLAPGAELTLPWREDFNGLAYVMAGRGSVGAERRPIHLGQTAVFGAGSSLTVRADEKQDSHTPDLEVVLLGGQPIREPMAHYGPFVMNTKDELQQAFDDFQKGRLGTIPAVHGMTAEGI
>NZ_CP049838.1|WP_028806966.1|5164781_5165264_+|SseB-family-protein
MYGYGQPMDGGAAQQQYAPPQQQMPGGHGGYGQQPPLYPEPSPPSLADAVRAFTTGQLAAEDFQQVFATSKVYCPRGDNPGFLALHNTQQPVIPMFTSLKELRRYAGKESKYFVITGSEMIDLLPTGYGFVLDMEGEHRMVFDAKAVEQMVEFAMRRMYG
>NZ_CP049838.1|WP_171398327.1|5162732_5164574_-|acyl-CoA-dehydrogenase-C-terminal-domain-containing-protein
MGHYKSNLRDIEFNLFEVLGRDKLYGTGPFGEMDTETAKSILEELTRLAENELAESFTDADRNPPVFDPETNTAPVPASFKKSYQAFMDSEYWRLGLPEEIGGTTAPPSLIWAYAELILGANPAVWMYSSGPAFAGILFDEGNDVQKKIAQIAVDRQWGSTMVLTEPDAGSDVGAGRTKAVQQEDGSWHIEGVKRFITSGEHDMSENILHYVLARPEGAGPGTKGLSLFMVPKTLFDFETGELGERNGVYATNVEHKMGLKASNTCEMTFGDRHPAKGWLIGDKHDGIRQMFRIIEFARMMVGTKAISTLSTGYLNALEYAKERVQGPDLANFMDKAAPKVTITHHPDVRRSLITQKAYAEGMRALVLYTASVQDAIAVKEANGEDAKTEHALNDLLLPIVKGYGSEKGYEQLAQSLQTFGGSGFLQEYPIEQYIRDAKIDTLYEGTTAIQGQDFFFRKIVRNQGAALNSLAEDIKKFLALGTGGEELAGAREHLAKAAVELEAIVGLMLTDLAATEQDVKNIYKVGLNTTRLLLASGDVIVGYLLLKGAAIAAEKLESAATKAVSAKDVAFYTGKIAAAKFFAADVLPGVTLARKIAAGVELDLMELDEAAF
>NZ_CP049838.1|WP_171398326.1|5161289_5162612_-|M18-family-aminopeptidase
MSAPSRFDRGHTDDLMTFLTASPSPYHAVANAAERLEKAGFRQVSETDAWDAETSAASAAGSGGRYVLRGGAIVAWYVPEGAAPHTPFRIIGAHTDSPNLRVKPLPDTGAHGWRQVAVEIYGGPLLNSWLDRDLGLAGRLTLRDGSTRLVDIGRPLLRVPQLAIHLDRAVNTDGLKLDKQRHLQPVWGLANDVRDGDLIAFLEQEAGLAAGQVTGWDLMAHSVEPPAYLGRDEELVAGPRMDNLLSVHAGTAALTAVATGGEGLPYIPVLAAFDHEENGSQSDTGADGPLLGSVLERSVFARGGSYEDRARAFAGTVCLSSDTGHAVHPNYAERHDPTHHPRVNGGPILKVNVNNRYATDGSGRAIFAAACEKAGVPFQNFVSNNSMPCGTTIGPITAARHGIRTVDIGVAILSMHSARELCGDADPYLLANALVAFLEG
>NZ_CP049838.1|WP_171394949.1|5176256_5177048_-|ABC-transporter-permease
MSSLSLAVRDSSTMLRRNLLHARRYPSMTLNLLLTPVMLLLLFVYVFGDAMSAGIGGDGADRSDYIAYLVPGLLLMTIGSTTIGTAVSVSMDMTEGIIARFRTMAIHRGSVLFGHVVGSVIQCVMSVTLAGAVGVAIGFRSTDATALEWLAAFALLVLFATALTWLAVGMGLSSPNPEAASNNAMPLIFLPLISSAFVPVDAMPGWFQPIAEYQPFTPAIETLRGLLLGSEIGHNGWLAVAWCLGLAVLGYFWSKSLFDRDPK
>NZ_CP049838.1|WP_171398336.1|5177044_5178061_-|ATP-binding-cassette-domain-containing-protein
MPSSVMPTPSLGDGHPSPIAVSTIGLRKSYGDKTVLDGIDLRIPAGSVFALLGPNGAGKTTAVKILSTLITADGGQAQVAGHDLTTSPDGVRAAIGVTGQFSAVDGLITGEENMLLMADLHHLSRAEGRRVAAELLERFDLVDAAKKPAATYSGGMKRRLDIAMTLVGSPRIIFLDEPTTGLDPRSRHNMWQIIRELVSDGVTVFLTTQYLEEADELADRIAVLNDGRIAAEGSAEELKRLIPGGHVRLRFSDPAAYQDAASTLREVTRDDEALALQIPSDGSQRELRSILDRLDSAGIEADELTVHTPDLDDVFFALTGSTVPVRSSRPDQPKEAVR
>NZ_CP049838.1|WP_171398337.1|5178121_5178970_-|DUF4097-family-beta-strand-repeat-protein
MPSFDTPEPISVTARVDAGSLQFTAGDRPDTVVEVRPRDPEKDLDTRAAAQTEVTYASGVLTIRTPKPTLFGLGRTGTVDVTVDLPTGSRVDTTGAWTQVIGDGRLGEVRVKNSAGDVRLDTTGPLELTASHGTITVDRVEGSAEITASSGSMRVGFVDGPAVLKNSHGSTTVGAVTGELRVSGANGDIDITRAEDSVTATTAHGTLRVGEVVRGTVQLETSYGAIDVGIREGTAAWLDVSSDSGQVRNTLTASESPEKTEDTVKIRARTRFGNIHVRRAKA
>NZ_CP049838.1|WP_171398338.1|5179096_5179612_-|toxin-antitoxin-system-HicB-family-antitoxin
MDLTPYVDTLRRELAVAAEAGGDEARELAERLTAPLESATRLTMLHVLSAATDEITRDLAPGSVDVRLRGLDPHFVVTLPPRDGGAITEPVAPAEPLKAPADGDEGGTARVNLRLPAHLKARAEEAATREGLSVNAWLVRAVSAAVEGGARPPRTTEKTQTLGQSFTGWVR
>NZ_CP049838.1|WP_171398339.1|5180079_5181117_+|dioxygenase
MTGNSGNTANTAGAEHDQQGPRHKRDLTRRKVVVAGAGAAVAVGAGGALAAGAFAGEKGGNKPKAAASASAGEVCYKLTSETTEGPYYIDADKLRQDITEDKEGIPLTLALKVIDSETCKPIANAAVDVWHCDALGIYSGYESLSTGGGGGAPTDAPSGTPTGTPTDVPTGTPTGEPPSGGGGGGGHEEPTDDERYLRGTWKTDRQGRVTFKTIFPGWYRGRTVHIHTKVHVNGEWTDAGYEGGNTCHTGQFFFDEESVLASAEVEPYSTSTTERTTLTEDTIYDQSGVQGGLLKLKYNKKNIAKGVVGSITMGVEPDATHDGTDDAVQPGASETASAEASASSS
>NZ_CP049838.1|WP_171398340.1|5181160_5181838_-|hypothetical-protein
MDLLEPHLRLLAEVFDVAAPGAPWALAGGYALQAHELLQRPHANVDLATESAEAMPRLAEALGAALTSRGVHEATVRDTDPLSAHLAVLDRTTDTVLRLALHKETFWSPPVPTPYGPALSLPDAVGTKVRALYDRGLAVDLIDARAASARFTHPDLEELARRHARDDFDLPTLQTRLTGTDHYPDTAFTAYGLTEDQLTDLRAWAQSWSTDIAERLLEEGASPDE
>NZ_CP049838.1|WP_171398341.1|5181877_5182690_-|hypothetical-protein
MSPTPSPTSPLPSFQDGSIDAILGHAARATLPYKRANRDEGHATAFWFNELIPSEGAAGDGEVVRQYLVTAAEPTRVDLAEITLRPELCDPAPSAERLVMTGFADGWTPLPGLGVAVLPASVLHTYADRKGWSWSTDEITDGVAARAEDLAGIGADPVRAYVLGHDTGEGGEREQAVVVGVLVRAGDGSIRWGGELPQGCVGAPVFTSVILKKNQFRLVCAGVALPADGRSPGHHPVATFDRIRTALDPDAHPETAEGGSTRRWWRRRAH
>NZ_CP049838.1|WP_171402124.1|5182694_5184158_-|FG-GAP-repeat-protein
MRVNELVFRRGWRGAVVLLAGLLGAAALPAAPAVAVHGAVPGDFNGDGYRDAVLPAPGANVAGKERAGAVVVLYGAKTGLSATRRALITQNTAGVPDTAEAGDGFGSATATADLNRDGYADLVVGAPFESTAKGAEAGSVTVLWGSRSGLTTGTDLPASATAGMDPYHYGADLAATRGASAARSEVLVASWGGAVRFTGPFTRTGGYGASAVAADSSWGDSVALGDFDGDGSPEHVNVTYGQGGETGGFVFVDPEDQDHVGLPSRLTHGNGHIAATGDVNGDGYDDLVVGDPDEPEVAGVDGASGGRVLVWRGSAAGIAPDAVPEQITQDTAGVPDASEKGDVFGGALTVADLNRDGLADLVIGAPRESVGTKAQAGQVTVVPGRRTGVLGTGSYAFTQDTAGVPDASEAGDGFGTTVAVGDVNRDARPELFVSASGENESTGAVWTFPGFTTGPTAARSRVFTAPSVGLTQQNSVLLGGYGLGWVI
>NZ_CP049838.1|WP_171402125.1|5184422_5185667_+|polysaccharide-lyase-family-1-protein
MNANAGTVDLYHQTLAAKDGWASSGTGTTGGTKADAAHTFTVSTRAQLVKALGSASDTTPRIIKIKGTIDANTDDAGKKLTCADYASGTGYSLSAYLKAYDPSSYGTSKLPSGTQEKARAAAQTKQAKNIVFKVPANTSVVGVPGTNAGISGGMLQIQSVDNVVVRNLTFAATEDCFPQWDPTDGDDGNWNSNYDSVTLRGATHVWADHNTFTDAPHLDGANPKYYGREYQIHDGALDITKSSDLVTVSRNQFTNHDKTMLIGSSDSEPSGKLRVSIHHNIWKGIVQRAPLARVGQVHIYNNYYDVTTLNGYATQYSINSRAKAQVVAENNYWKVPTGGKVAKLLSGDGTGAIKGSGNLVNGTVTDVVAAYNAASSKDLKTTVNWTPALTSGLETSAKNLPTTLGTTTGASVLK
>NZ_CP049838.1|WP_171398342.1|5185729_5186221_-|hypothetical-protein
MAVPNVIPIAYEPRHRTESIGRYADGQFLASVTYAFPEGFRLDDGWEEHKRLYTVLHTFDADGTYRDSDIWCAGTWAEQQRNPHGDDSVLTRARVRLATLLRSLPRRSYTDIAVRPFRLTFEGVLFGLVIREDKDEDGTPETWAELYPDRLAFADPWDGTYDT

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP049838_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049838_10

5259141-5259368

Orphan

Consensus_repeat	Method
CGACCGCGTCGGTGTCGG	PILER-CR

3 spacers

The CRISPR arrays of NZ_CP049838_10

>merge|NZ_CP049838|10|5259141-5259368|PILER-CR
CGACCGCGTCGGTGTCGGCTGCGGCCGGGCCGACGGCGGCCGCGAGCAGACCGGCGTCGGCCACGATCGCGTCGGTGTCGGTCACGGGCGCCCCGGTGGCGGCTGCCGAAGCACCGGATCCCCGATGTGTCCCATGCCCCACAGAGCCGACCGCGTCGGTGTCGGCTGCGGCCGGGCCGACGGCGGCCGCGAGCAGACCGGCGTCGGCCACGATCGCGTCGGTGTCGG

>NZ_CP049838|10|1|5259141-5259368|PILER-CR
CGACCGCGTCGGTGTCGG	CTGCGGCCGGGCCGACGGCGGCCGCGAGCAGACCGGCGTCGGCCA
CGATCGCGTCGGTGTCGG	TCACGGGCGCCCCGGTGGCGGCTGCCGAAGCACCGGATCCCCGATGTGTCCCATGCCCCACAGAGC
CGACCGCGTCGGTGTCGG	CTGCGGCCGGGCCGACGGCGGCCGCGAGCAGACCGGCGTCGGCCA
CGATCGCGTCGGTGTCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049838.1\|WP_171402131.1\|5245727_5246339_-\|extensin	unknown	unknown	gnl\|CDD\|237864
NZ_CP049838.1\|WP_171398391.1\|5249600_5249759_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398398.1\|5264707_5265070_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398395.1\|5259485_5260160_-\|DUF4255-domain-containing-protein	unknown	unknown	gnl\|CDD\|379449
NZ_CP049838.1\|WP_020133270.1\|5267004_5267208_-\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_CP049838.1\|WP_171402133.1\|5267576_5267870_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398397.1\|5261307_5264265_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|197715
NZ_CP049838.1\|WP_171398401.1\|5267892_5268255_+\|DUF952-domain-containing-protein	unknown	unknown	gnl\|CDD\|377607
NZ_CP049838.1\|WP_020132884.1\|5245244_5245670_-\|phage-tail-protein	unknown	unknown	gnl\|CDD\|377718
NZ_CP049838.1\|WP_020132886.1\|5249755_5250280_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398402.1\|5268368_5271404_+\|M4-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341060
NZ_CP049838.1\|WP_171398399.1\|5265126_5265339_+\|DUF4287-domain-containing-protein	unknown	unknown	gnl\|CDD\|379478
NZ_CP049838.1\|WP_171402132.1\|5257137_5259135_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|223540
NZ_CP049838.1\|WP_171398392.1\|5250784_5252377_-\|phage-tail-sheath-family-protein	unknown	unknown	gnl\|CDD\|226028
NZ_CP049838.1\|WP_020132887.1\|5250279_5250723_-\|phage-tail-protein	unknown	unknown	gnl\|CDD\|274049
NZ_CP049838.1\|WP_171398394.1\|5254244_5255630_+\|ricin-type-beta-trefoil-lectin-domain-protein	unknown	unknown	gnl\|CDD\|238092
NZ_CP049838.1\|WP_171398393.1\|5252690_5254115_+\|hydrolase	unknown	unknown	gnl\|CDD\|214791
NZ_CP049838.1\|WP_171398400.1\|5265364_5266873_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223587
NZ_CP049838.1\|WP_171398396.1\|5260299_5260959_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP049838.1\|WP_171398390.1\|5246790_5248563_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090

Protein	Function_ID	Function_description	E-value
NZ_CP049838.1\|WP_171398397.1\|5261307_5264265_+\|AAA-family-ATPase	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	5.66338e-14
NZ_CP049838.1\|WP_171398396.1\|5260299_5260959_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.42231e-21
NZ_CP049838.1\|WP_171398402.1\|5268368_5271404_+\|M4-family-metallopeptidase	gnl\|CDD\|341060	cd09597, M4_TLP, Peptidase M4 family including thermolysin, protealysin, aureolysin, and neutral protease. This peptidase M4 family includes several endopeptidases such as thermolysin (EC 3.4.24.27), aureolysin (the extracellular metalloproteinase from Staphylococcus aureus), neutral protease from Bacillus cereus, protealysin, and bacillolysin (EC 3.4.24.28). Typically, the M4 peptidases consist of a presequence (signal sequence), a propeptide sequence, and a peptidase unit. The presequence is cleaved off during export while the propeptide has inhibitory and chaperone functions and facilitates folding. The propeptide remains attached until the peptidase is secreted and can be safely activated. All peptidases in this family bind a single catalytic zinc ion which is tetrahedrally co-ordinated by three amino acid ligands and a water molecule that forms the nucleophile on activation during catalysis. The active site is found between two sub-domains; the N-terminal domain contains the HEXXH zinc-binding motif while the helical C-terminal domain, which is unique for the family, carries the third zinc ligand. These peptidases are secreted eubacterial endopeptidases from Gram-positive or Gram-negative sources that degrade extracellular proteins and peptides for bacterial nutrition. They are selectively inhibited by Steptomyces metalloproteinase inhibitor (SMPI) as well as by phosphoramidon from Streptomyces tanashiensis. A large number of these enzymes are implicated as key factors in the pathogenesis of various diseases, including gastritis, peptic ulcer, gastric carcinoma, cholera and several types of bacterial infections, and are therefore important drug targets. Some enzymes of the family can function at extremes of temperatures, while some function in organic solvents, thus rendering them novel targets for biotechnological applications. Thermolysin is widely used as a nonspecific protease to obtain fragments for peptide sequencing. It has also been used in production of the artificial sweetener aspartame.	9.09943e-76
NZ_CP049838.1\|WP_020133270.1\|5267004_5267208_-\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.10954e-34
NZ_CP049838.1\|WP_171398401.1\|5267892_5268255_+\|DUF952-domain-containing-protein	gnl\|CDD\|377607	pfam06108, DUF952, Protein of unknown function (DUF952). This family consists of several hypothetical bacterial and plant proteins of unknown function.	1.34752e-21
NZ_CP049838.1\|WP_020132884.1\|5245244_5245670_-\|phage-tail-protein	gnl\|CDD\|377718	pfam06841, Phage_T4_gp19, T4-like virus tail tube protein gp19. This family consists of several tail tube protein gp19 sequences from the T4-like viruses. This family also contains bacterial members which suggest lateral transfer of genes.	2.99551e-36
NZ_CP049838.1\|WP_171402131.1\|5245727_5246339_-\|extensin	gnl\|CDD\|237864	PRK14950, PRK14950, DNA polymerase III subunits gamma and tau; Provisional.	9.8842e-09
NZ_CP049838.1\|WP_171398390.1\|5246790_5248563_+\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	1.39143e-06
NZ_CP049838.1\|WP_171398399.1\|5265126_5265339_+\|DUF4287-domain-containing-protein	gnl\|CDD\|379478	pfam14117, DUF4287, Domain of unknown function (DUF4287). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 70 and 180 amino acids in length.	9.67068e-28
NZ_CP049838.1\|WP_171402132.1\|5257137_5259135_-\|ATP-binding-protein	gnl\|CDD\|223540	COG0464, SpoVK, ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones].	1.98745e-27
NZ_CP049838.1\|WP_171398392.1\|5250784_5252377_-\|phage-tail-sheath-family-protein	gnl\|CDD\|226028	COG3497, COG3497, Phage tail sheath protein FI [General function prediction only].	1.10549e-60
NZ_CP049838.1\|WP_020132887.1\|5250279_5250723_-\|phage-tail-protein	gnl\|CDD\|274049	TIGR02241, hypothetical_protein_SCD8A.25c, conserved hypothetical phage tail region protein. This family consists of uncharacterized proteins. All members so far represent bacterial genes found in apparent phage or otherwisely laterally transferred regions of the chromosome. Tentatively identified neighboring proteins tend to be phage tail region proteins. In some species, including Photorhabdus luminescens TTO1, several members of this family may be encoded near each other.	1.50515e-39
NZ_CP049838.1\|WP_171398394.1\|5254244_5255630_+\|ricin-type-beta-trefoil-lectin-domain-protein	gnl\|CDD\|238092	cd00161, RICIN, Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ligand binding occurs on exposed surfaces of the compact domain sturcture.	1.35228e-32
NZ_CP049838.1\|WP_171398393.1\|5252690_5254115_+\|hydrolase	gnl\|CDD\|214791	smart00728, ChW, Clostridial hydrophobic, with a conserved W residue, domain.	1.66613e-10
NZ_CP049838.1\|WP_171398400.1\|5265364_5266873_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	1.19734e-122
NZ_CP049838.1\|WP_171398395.1\|5259485_5260160_-\|DUF4255-domain-containing-protein	gnl\|CDD\|379449	pfam14065, DUF4255, Protein of unknown function (DUF4255). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 190 and 320 amino acids in length.	3.13031e-45

>NZ_CP049838.1|WP_171402132.1|5257137_5259135_-|ATP-binding-protein
MGPRPDSRDGAAALLVRLGGLRDRVGALVDRRAAVDPTAADPLRGLYLSEEAVRHLLSGGPATGPVDAVAPDPAPADSLSALAARLRLTELDTAILLIALAPDLDRDFEPLYGYLNDDVSRRRATVGLALELCGAPAHAAAARARFHSSAPLRAYGLLDVEEPERPFLSRSLRVPDRLLAHLLGDDTPDAALHGHLHPLPPPLPADDEDFVRLLAHRMREGGPLIAYLREHREGDGLAAITSALRAAGVGALRFTGPEDRVPGLLREARLGGRAVVLSGLPDQPGPLIGALADATDVTVLLTDPRPYDPHWSTHDPLVLEAPRRRAGGTAAWAAALDSAGPLDTAPGFDLAATVAPYRLGGERVARAARAASVLAAFEGGPLTADHVRLAARQQSASGLERHARRIRPDVGWQDLVLPERPLTQLHELALRARHRDRVLGDWRLSAGGGRGRGVLGLFAGESGTGKTLSAEVVAAELGLDLYVVQLSSVVDKYVGETEKNLERIFSEADRTDAVLLFDEADAVFGKRSEVKDAHDKYANMESAYLLQRLESFDGIALLTTNLRANIDEAFTRRLDLVVDFPFPDAGQRLALWRHGLCHVPCAADVDPGPLAKDFELAGGSIRSAVVTAAYLAAGRDEPVGDGDLLEGARREYRKAGRLVPGEANW
>NZ_CP049838.1|WP_171398394.1|5254244_5255630_+|ricin-type-beta-trefoil-lectin-domain-protein
MTLWTSLEPAAATVDPGGTTTVRLRVRNTGDVVDEYRFEPVGAVAPWTTVEPQTLRLYPGTTGTVELTFAPPRTPDATAGPNPYAVRITPTEHPDAVTVPEGNLTITPFTEVRAELVPPTVKGRFRGRPRLAIDNIGNTRLTASVAGTDMGDHLGYEFRPGSVQIEPGRAVFVDTTLRPRQIIWFGSKEQRPYALSVQRSGAVPLSVDGTFVQRGFLPRWLATALSLTVALAIAFVMIWLAYKPQVNTSASEKLAEAGSTALPSPSVSAPSAPKADASAAPLPEQQTSSAPAKEEDGSGGSTSGGSSGSGSGSGSGSGSGGSGGTKTTAPVPGAVIIGQASDRCIDITGAQNGKGKDGTPLQLWDCAGSANQKWVFKSDGTVRALGLCMDVAWGSKDDGAVIQVANCSGNPAQQWVLSQYGDLVNPQADKCIDAKDQGTGNGTKLQLWTCSGTPNQKWRAD
>NZ_CP049838.1|WP_171398393.1|5252690_5254115_+|hydrolase
MSLWTSLEPASVTVDPGSRATVRLRVRNTGDVVDEYRFEPVGAVAPWTTVEPQTLRLYPGTTGTVELTFAPPRTPDATAGPNPYAVRITPTEHPEAVTVPEGNLTITPFTEVRAELVPPTVKGRFRGRPRLAIDNIGNTKLTASLTGSDQGDRLSYELQPANVQIEPGRAVFVNTTLRPRQIIWFGSKEEQRYSLAVRRSGAQALEVDGTFVQRGFLPRWLATALSLTVALAIAFVMIWLAYKPQVNTSANEKLAEAGVSTLAPSPSATPSAPALVPTPTAPVVVEAPASSQAPADSGSGSGGGDGGGGSESKAPVKPKQETAADAVNKLAARSDGRHICYRAYVADKGWQDPVCDGAIAGTTGKNLPIKALNIATARTGGVTGNAAHVVGGWLTGDKWSKAGDGVNMWMGSSKPAVAAMEGYTIKTIEGSVCQNAHVKDRGWLGNGCTKAGDWIYGGSPMEQKLQLEAVRFTV
>NZ_CP049838.1|WP_171398392.1|5250784_5252377_-|phage-tail-sheath-family-protein
MPSYLSPGVYVEEVASGSRPIEGVGTSVAAFVGLAPTGPLNEPTLVTNWTQYVAAFGDFTDGYYLAHSVYGFFNNGGSAAYVVRVGGTSAGAAGDAKSPAAVTGSGSAPAALPAGEPKQLGTFTVTAVAPGENGGPLSVEVADAEGEGPAERFKLIVKDGDKAVETFDVSAKKGNRSYVVTQVKERSKLITVAEAAPAAQLARPDNQTVALAAPPAGAPAGAVEAAQPVGPAQYLGDSSDRTGFGGLEAVDEVSMVAVPDLMAAYQRGAIDLESVKAVQLGLIAHCELMGDRVAIIDPPPGLNARQIRVWRQETAGYDSKYAALYYPWIKSFDPSAGKARLIPPSGHVAGVWARNDSERGVHKAPANEVVRGAVDLEIQITRGEQDLLNPIGVNCIRAFPGRGIRIWGARTLSSDPAWRYLNVRRYFNYLEESILIGTQWVVFEPNDHALWARIRRNVSAFLVNEWRGGALFGARPEEAFYVKCDEESNPPESVDLGRVICEIGIAPVKPAEFVIFRLAQFSSGNGELEE
>NZ_CP049838.1|WP_020132887.1|5250279_5250723_-|phage-tail-protein
MSLQPGDALTSHNFGLQIDGVMVEYLAEVSGLSLEQDVIEYQQVSAQGKPVTKKLPGVKKAGTCTVVRGMTQSAAFNQWITESINGVMGTARKNATIMVMDYQNNPVKRYNMRNAWCSKIDTSSVKAGEASALTETVTITFEELVIE
>NZ_CP049838.1|WP_020132886.1|5249755_5250280_-|hypothetical-protein
MRRTAVRAAAASGEPQEALPATAVPESASLSGAASAFSAPGAAAAPAPAPYRLQTEFPFELPRGYVDEAGTVHRDGVMRLATARDELVPLRDIRVQENPAYLSVVLLGRVITRLGSLPLVHDGVVENMFASDLAFLQDFYRQVNAEGHTRASVQCPHCSEPFEVELGGSRLGES
>NZ_CP049838.1|WP_171398391.1|5249600_5249759_-|hypothetical-protein
MTYATDRLHEEIAYVAYHFHWGQDEILDLEHHDRRRYADQIAALVTRGGAEG
>NZ_CP049838.1|WP_171398390.1|5246790_5248563_+|hypothetical-protein
MAARCTGAPRGVERRSGGSGSVRALGAPALWADAGVPTGAGVAGGVGDATGGLSGVAGPGRPEGRLVGAPRPARRRGAAAPEAARWTLVAAWDAGADTGAGAGAEPVVGAGELATERAGSAGPVCAGTELLPPPGAGVAGRAGGVTGTGADTARCTSVGAVRRPAGAGAGVGTGVVVGRDGVEAGAGAVAACCTLGVDARPPSPEPGVGPGIEAVPEPGPGAEVEAGVVAARCTLGVGVRPPSCEDAVGPGIEAVPEPGPGAEVEAGVVAARCTLGVGVRPPSCEDAVGPGVEAGPAPEAALAPAPGPGPGGEVGAVAARCTLGIDARPPSREDAVGPEVESGVVAARCTLGDDVRPPPPEDEPGRVGEPWPAPGPEPSAGPEAGVEAGPGEDTEPEPGRRPEPEPDPEAELRAADDPVGTSAVGVERASVAGRLLTGTGATVPERGAVAAGGPGVDVGDGPRSVPPGGGAAGPLPGECVPVPPGAPPGEEDGAVRAGTARCTLWPALAEGGPADPAEPADGAAAPDAPAEAEPADAAGDFADNGRAEPVCVAGVAPPTADGPGTVAPASPAPGTARCTRTGAPPGAEPS
>NZ_CP049838.1|WP_171402131.1|5245727_5246339_-|extensin
MVSPAPVQRHAVKAPVPLRRTTPGATAGGPVARPYPTPGLTPMPAPATAPSTPPAPPAPVVQRRSLPAPGAAATAPVRPAAPPAQASPIPVPVPLPVPTPAPLPLPAAPTPPAPVVQRRHAAPPPTLRTPPRGTGGTPPGGDQGAADPAHAHPQAHPGFDPRALTDFQLDELTHRLTGRITRLLRTELRLDRERIGRLRDPRH
>NZ_CP049838.1|WP_020132884.1|5245244_5245670_-|phage-tail-protein
MPSDLDPGSTIFFTLTIDGESLGFFNGCEGLSSQVEIEHRQEGGNNGFVWQLPSRVTFSTIRLTRPLTPDTTKVAKWISSVTTGVTRPTAQIAALRADGSEVARWGLIDVLPVSWQGPSLSPDSPGVATEVLEITHHGFTD
>NZ_CP049838.1|WP_171398395.1|5259485_5260160_-|DUF4255-domain-containing-protein
MIHEVDEVLKELLGGGALAGSGIDVSFEAPTRDWAARRNAPVINTYLYDIREDVTRRQRGQMAVRDERDIVVKRRQPPRWFRLSYLVTAWTRTPQDEHRLLSAVLATLLPREMLTADELPGSLGALGLAMPVTVAGIQTESRSLAEIWSALGGELKPSLDLVVTAPFPAYPEYDAGPPVTEGAAVRLRGMDGDPPESGERAHRPHQVAAARAAREAATRRPDQR
>NZ_CP049838.1|WP_171398396.1|5260299_5260959_-|response-regulator-transcription-factor
MGAALPGTAIGTRRRIPVAVQAPDPISREGAVSQLRGRPEVEVREEVSAAAGTVALLIEDTLDEGALGRLRRIVRSEGARAVLVVGTIRETELLDVIECGVGAIVWRREATAHRLVQAVLAAHRGDGDLPADLLGRLISQVGTLHRGAAGRPGAPSLGLAPREVDVLRLVAEGLDTGEIASKLSYSERTVKNVMHGLTTRLHLRNRAHAVAYALREGYI
>NZ_CP049838.1|WP_171398397.1|5261307_5264265_+|AAA-family-ATPase
MTGPLREREDAHALLTAEAERARAGGGRLVLLRGATGTGRSAVLEAAAAHATHLGLRVLRARCSPDDTALPFSSVLHLLGSVPEFADVGPGDDDRGSAARLWRLLRSYADETPLMVAVDDVHLADEASRRWFVEAARRIDRLPVLLVVTERSQYDIDPRPAGLTHALSPSVVRTHTLAPLTDNASADLVRAAFPTASDRWTADCVRAGAGSPLLLRALLDDLDGAPPPTAVPRTCAALYPGSYPAAVSWWLDSAGPATAEVARTLAALEQAERTDRKDREARTERLERTEEMQRAGRAERAEGSVARNAAPAPVPVLAPVPVPDTAHEVLPAAEATAAATTETATEAATDTLAALVADASGADPARVSGWFTAMTRLGVLRPDRAGRPRYAHPLLQDAVLGGWSTARRQDAHRAVAQAMLRRGDHLDAVARQLLGSAPAGLRWALRVLRDAATVAARDARPGDAVRYLRRALQEPLPDDLRQRLLTELGSLEYASADTPAGIPRLAEALDLPAEPRDQVRTAIALGTALVGRGEVRTAVEVLRRLEARLAGHPDLARALQTASALLSDQDQTVRREAYRWLTDTAERSPELVGASGQALLVRYAATAGELPAQEAMRRLRTLLTEPADPLAEPFLLGTAAAVAQWADELDEAERLVERGLAGQRPTLLHPMEQALLDTRWDIAAARGAYGTLLAALPDAARARRTGGGPVNADAHTLLALVETGRTQEARRLADTFDLRDTPDSWELNRFLYARGVLRFTEGDVAGALHDFLECGRRQSARAVLSPVVTPWRTAAAECRLALGNPQEALALATEELRLARVWNTPRTTGRALRVLGRATRGRRGLELGAEAVAVLRDSPAEAELVASLLAHGRQLTDAGERGRGRDHLREGAERAERLGSVRLLNHAEQALRTAGGRRTTPAHTGSGALTGSERRIAELAADGRTNTEIADLLHVARRTVETHLTSAYRKLGIRRRGELRGVLDD
>NZ_CP049838.1|WP_171398398.1|5264707_5265070_+|hypothetical-protein
MRTALSVLRGYLPPLLVHLLIGLPTAVVVLCARWYITYGHCTYEDLGRHDLDHCTYDQIENSGFALIALVLFAAFVALLLVLFDGLRPLRTGRSFRPRLLTLPAILLPYAVYATYAANVG
>NZ_CP049838.1|WP_171398399.1|5265126_5265339_+|DUF4287-domain-containing-protein
MTEPVKGPASYFPSIEKKYGRPIAEWKTLIRASPLTRHMELVSWLKTEHGLGHGHANALVAHTLAEDAGV
>NZ_CP049838.1|WP_171398400.1|5265364_5266873_-|DEAD/DEAH-box-helicase
MNRNSSVRSRTDRRQGAPSRSAKPGRSGRGSRPAASGGEFALPVTLTPGLPAVETFAELDMPEKLLTALGAEGVTTPFPIQAATLPNSLAGRDVLGRGRTGSGKTLAFGLAMLARTAGQRAEPRQPLALVLVPTRELAQQVNDALTPYARALRLRIATVVGGLSIGRQASALRGGAEVVVATPGRLKDLIDRADCRLDRVAITVLDEADQMADMGFMPQVTQLLDQVRPDGQRMLFSATLDRNVDRLVRNYLHDPVVHSVDPSAGAVTTMEHHVLHVEDEDKHATTTEIAARDGRVIMFLDTKHAADRLAKKLLAVGVRAASLHGGKSQNQRTRTLAQFKDGHVTVLVATNVAARGIHVDNLDLVVNVDPPSDHKDYLHRGGRTARAGESGTVVTLVLPHQRREMTRLMVDAGITPQTTRVRSGEAELSRITGAQAPSGVPVVLTPPPAEERPARSASTARSRRGRPAAQGGGRPTAQGGRPTSQGRRRSPAKGNGNTANGR
>NZ_CP049838.1|WP_020133270.1|5267004_5267208_-|cold-shock-protein
MASGTVKWFNSEKGFGFIEQDGGGADVFAHYSNIATSGFRELQEGQKVTFDVTQGQKGPQAENIQPA
>NZ_CP049838.1|WP_171402133.1|5267576_5267870_+|hypothetical-protein
MGRTLAGVAVAAAVAVATLTGCSLQIEEASCGGGEYPVLAVNSGGSDCVPDGEEPAQGWARYPEGKVPEKVGDQWDTYWSTHTLDESGKIIELPEGQ
>NZ_CP049838.1|WP_171398401.1|5267892_5268255_+|DUF952-domain-containing-protein
MIYHVVPLDDWNTAPERPYAPASLAEDGFVHCSPDEGTTLAVVNAFYRTGPRPLLALVLDEERLTATCAWEAAAPAPPPGVAEGTLFPHVFGPIDRDAVTRVLEVRWDENGTATGLTDIG
>NZ_CP049838.1|WP_171398402.1|5268368_5271404_+|M4-family-metallopeptidase
MAVPGGRPPPVRIPRGNGGTVRQSRASRQRPAESRAESSAGLPAASPAGLPVALRNGAAALIGVAALVVSAVPAVAVTPVPPSPGEVVPGPDTATPALVDGLRERAPAAPNAADAARAHLAAQRARYRIADPGRDLRPAGTVTAEDGREVVRLRQTYHGVPVLGGQYIVRMERQSDGGRVVTGTSGKYFTGLRADTTAAEVDDALAVERAVDAVLNELGAQGFTAYERGAAGGDGTESGEGEADGPPLTGTSHGLVVLPTGTGVLTRHITVRGADPARGEPVLREVYIDARAGYPVLQYSGIQTFGTPVTAAAGSAAGPAGSVRAAAAAAAAADDEPGTDTDTDTDTGSGVRLDGTTVPLRITHDETRDAYVLRDRSRIQNETEDVLATWDARGTWASEVSGSWPAGIQEFASPTPAFGADATEAGAVDAHWAAGQVYDYYKAGHGRDSLDGHGMSINSLVGTTDYGQPYVNAFWDGRKMVYGNGDAEYRPLSAGLDVVGHEMTHGVIGHSAELVYAGQSGAMNEALADYFGNAVQTDVLGVAMDDPQAGLLGETLCRTKSPADCAIRDLNDGRTTAKSFLGVGFGTDNGGVHLNSTIFSGALWDIREDLGPALADRIVYKALTEYLTPLDGFTQGRDAVIAAAKALGVGGSDLSAVQRAFNAHGIVPNWELALGVDSELLLERVNTFDSHLGAGGGWWTASTSNEEGSEAYSVWAGRTDGTGQLKLMSPNDGRYHVNPVTDGKTVVWQAYSAGSVAVLARPLAGGPVKTLFSGRSMGPDLAVEGDVVAFDYMARAGLRNVVHLRMSDPANEVRLGGGRYHRTSFPSLSHGRIAYQEVQRVTLAATYEYNTRVLDLATGEDRVIQQAASGTGLGPTAITGGHVYWLLDEIDQNGVTTLRRAALDGSGVTDLSPETGPDALNVSDVTASEEAVTMTARTPDTQVRNATLSKLWQFTPTSGNDGAVRRSRVSCNRGEQLSAAAASGTRVLWLDATTGISDVVTRARPAGTCED

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP049838_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049838_11

5323676-5323769

Orphan

Consensus_repeat	Method
CAAGTACAACCACGGTCAGGACGAGCACGGCAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049838_11

>merge|NZ_CP049838|11|5323676-5323769|CRISPRCasFinder
TAAGCCGGACCACGGCAAGTACGACCACGGTCAGAACGACCACGGCAAGTACAACCACGGTCAGGACGAGCACGGCAAGTACGACCAGGGCCAG

>NZ_CP049838|11|8|5323676-5323769|CRISPRCasFinder
TAAGCCGGACCACGGCAAGTACGACCACGGTCAG	AACGACCACGGCAAGTACAACCACGG
TCAGGACGAGCACGGCAAGTACGACCAGGGCCAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049838.1\|WP_171398441.1\|5316409_5317282_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262
NZ_CP049838.1\|WP_171398451.1\|5329363_5330200_+\|ABC-transporter-permease	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398447.1\|5324176_5324746_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398449.1\|5326345_5327119_+\|DUF2637-domain-containing-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398453.1\|5331628_5332294_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP049838.1\|WP_171398440.1\|5313844_5316214_+\|histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP049838.1\|WP_171398443.1\|5318678_5319920_-\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP049838.1\|WP_171398450.1\|5328443_5329364_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213235
NZ_CP049838.1\|WP_171398444.1\|5320184_5320448_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398438.1\|5311454_5312516_-\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|377085
NZ_CP049838.1\|WP_171398454.1\|5332381_5333740_-\|exo-alpha-sialidase	unknown	unknown	gnl\|CDD\|271234
NZ_CP049838.1\|WP_171398437.1\|5310402_5311092_+\|GAF-and-ANTAR-domain-containing-protein	unknown	unknown	gnl\|CDD\|377145
NZ_CP049838.1\|WP_171398445.1\|5321559_5322249_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398448.1\|5324735_5325872_+\|HTTM-domain-containing-protein	unknown	unknown	gnl\|CDD\|214802
NZ_CP049838.1\|WP_171394573.1\|5321419_5321563_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398439.1\|5312600_5313707_-\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP049838.1\|WP_171402138.1\|5336365_5336842_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398442.1\|5317336_5318416_-\|acyl-CoA-desaturase	unknown	unknown	gnl\|CDD\|239583
NZ_CP049838.1\|WP_171398452.1\|5330225_5331632_+\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP049838.1\|WP_171398455.1\|5335021_5335204_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP049838.1\|WP_171398441.1\|5316409_5317282_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	1.10987e-10
NZ_CP049838.1\|WP_171398453.1\|5331628_5332294_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.70842e-65
NZ_CP049838.1\|WP_171398437.1\|5310402_5311092_+\|GAF-and-ANTAR-domain-containing-protein	gnl\|CDD\|377145	pfam03861, ANTAR, ANTAR domain. ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.	5.29591e-14
NZ_CP049838.1\|WP_171398443.1\|5318678_5319920_-\|serine/threonine-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	2.50482e-38
NZ_CP049838.1\|WP_171398450.1\|5328443_5329364_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	9.52508e-98
NZ_CP049838.1\|WP_171398454.1\|5332381_5333740_-\|exo-alpha-sialidase	gnl\|CDD\|271234	cd15482, Sialidase_non-viral, Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.	1.74267e-12
NZ_CP049838.1\|WP_171398440.1\|5313844_5316214_+\|histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.03667e-27
NZ_CP049838.1\|WP_171398438.1\|5311454_5312516_-\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	2.63743e-67
NZ_CP049838.1\|WP_171398448.1\|5324735_5325872_+\|HTTM-domain-containing-protein	gnl\|CDD\|214802	smart00752, HTTM, Horizontally Transferred TransMembrane Domain. Sequence analysis of vitamin K dependent gamma-carboxylases (VKGC) revealed the presence of a novel domain, HTTM (Horizontally Transferred TransMembrane) in its N-terminus. In contrast to most known domains, HTTM contains four transmembrane regions. Its occurrence in eukaryotes, bacteria and archaea is more likely caused by horizontal gene transfer than by early invention. The conservation of VKGC catalytic sites indicates an enzymatic function also for the other family members.	7.76994e-71
NZ_CP049838.1\|WP_171398439.1\|5312600_5313707_-\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	8.55079e-14
NZ_CP049838.1\|WP_171398442.1\|5317336_5318416_-\|acyl-CoA-desaturase	gnl\|CDD\|239583	cd03506, Delta6-FADS-like, The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases are required for the synthesis of highly unsaturated fatty acids (HUFAs), which are mainly esterified into phospholipids and contribute to maintaining membrane fluidity. While HUFAs may be required for cold tolerance in bacteria, plants and fish, the primary role of HUFAs in mammals is cell signaling. These enzymes are described as front-end desaturases because they introduce a double bond between the pre-exiting double bond and the carboxyl (front) end of the fatty acid. Various substrates are involved, with both acyl-coenzyme A (CoA) and acyl-lipid desaturases present in this CD. Acyl-lipid desaturases are localized in the membranes of cyanobacterial thylakoid, plant endoplasmic reticulum (ER), and plastid; and acyl-CoA desaturases are present in ER membrane. ER-bound plant acyl-lipid desaturases and acyl-CoA desaturases require cytochrome b5 as an electron donor. Most of the eukaryotic desaturase domains have an adjacent N-terminal cytochrome b5-like domain. This domain family has extensive hydrophobic regions that would be capable of spanning the membrane bilayer at least twice. Comparison of sequences also reveals the existence of three regions of conserved histidine cluster motifs that contain the residues: HXXXH, HXX(X)HH, and Q/HXXHH. These histidine residues are reported to be catalytically essential and proposed to be the ligands for the iron atoms contained within the homolog, stearoyl CoA desaturase.	5.6723e-63
NZ_CP049838.1\|WP_171398452.1\|5330225_5331632_+\|two-component-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.32062e-35

>NZ_CP049838.1|WP_171398445.1|5321559_5322249_+|hypothetical-protein
MTAPRGREQSLHGDGRTPSAMDALRLRRLNRWQAETLKEDLADLYVESSRARPGEGYRGREAFLRRLTGAIRRPGFALLIAESTAFAGCVYGFPVRREGTWWRGFDGPLPRSVEQLTASGHVFAITETVVHPHTDDKGLARRLQYRLLADHHASLGATLVEQSDSAICKAFLSWGWQDIGLVRRPSDQQVLRPSDPVVLRALVLPLGLGPRTAAHPDGLAHENRTQRPG
>NZ_CP049838.1|WP_171394573.1|5321419_5321563_+|hypothetical-protein
MTLPQLNVYRHERGTRIRSIDVDLTVVTFCDVGGRSCGIPVVMGGAP
>NZ_CP049838.1|WP_171398444.1|5320184_5320448_-|hypothetical-protein
MESPEPPAAGNVDVRLVASSPEAARQVAEVLRRCFASSEQRSYPVGTAAGGTRLHLTVDTARAAEPARSWLVTSRSSGDGRTQTDEI
>NZ_CP049838.1|WP_171398443.1|5318678_5319920_-|serine/threonine-protein-phosphatase
MTDGGRKPNRIGVDRSEGFGERLLGVLLDRAHEMPPELIAPLVAEEVARVGGREVSILLQDYEQVLLVPLPGRRLKVGGPEPVEGSPAGEAFLSRRTVEVPQDGSVRMYLPLLDGSDQIGAMALTLDSVDDDDRRLLRRLAGLVADMIVTKDAYTDQFFQARRSSPMSVAAEIQWSLLPPLTMTVPQVEVAGILEPAYDVAGDSFDYALNGDILHVAMLDAMGHGLDAATMATVAVGAYRHTRRAHTDLSQVYAFMDRAINEQFGPDHFVTAQMMILDITSGRLQWVNAGHPAPFLIRDRVVVDRLESPTTLPVGFGGEEPVVSERMLQPGDRLLCFTDGLIEEHQAGGAQFGEEQLIEWTNRILHARTAVRAVVRGLSHALKQERGGTTTDDATIFLIEWRGGDADHLATLD
>NZ_CP049838.1|WP_171398442.1|5317336_5318416_-|acyl-CoA-desaturase
MTTNTSVRPPPSGTSGSDFARLSRKIADAGLMGRRPGYYALRITVVTGLYVGGWAAVALVGDSWWTLAVAVFLAVVFGQVALLAHDAAHRQVFRRRRASEASGRIAGAGVGMGYGWWHDKHTRHHANPNHAELDPDLDPNLLVWSQDQARAAKGLPRLLGRRQAVLFFPLLTLEGFNLHVSSVRALADRSLKHRTLDGTLLFAHFAVYLTVLLWLLPPGMAIAFLAVHQCLFGVYLGSLFAPNHKGMPILTGEDRPDFLRRQVLTSRNVRGGRFTDIALGGLNHQIEHHLFPSMPSPNLRRARTIVRRYCEELGLDYVETGLITSYRQALASLHQAGAPLRQARVPAQAPASAIGGSDV
>NZ_CP049838.1|WP_171398441.1|5316409_5317282_+|helix-turn-helix-domain-containing-protein
MAAKNNPTVRRRRLGAELRRLRVASGLKSTEAAERLMVSQPKISHMENGNRAISPRDVRDLCAIYEVTDQQVIESLMEMARESGQRGWWHPYGDLYDSVYIGLETDAASLHTYAPMVVPGLLQTPAYAQAVIGETIPRLTGEQAVTHLKVRLRRQHRIYDPACPLRLWVILDESALRRVVGGPDVMREQLEHLNALGAEPHITVQVLPYTAGAHPGLAGQFSLLRFADSPEAGVVYLERFTSDLYLEKPSDVRHFSVMYDHLQAQALTPDSSRDFITCTARTYGDAAINS
>NZ_CP049838.1|WP_171398440.1|5313844_5316214_+|histidine-kinase
METIRNWLLPALLATGQIAWLWPGAGLAGEGVPGAAALVAVLGAVVAETAALGRRRRAPVRALAWSLGALLVGQAAWPDGYFGVGAPVALYSVAVRCPVPVTVRAVPAAVGVEWLLSLVHVGVRPALASEWVLGALLYVVCAGLGEARRQWLRGRSLATRLLAGAEEARRRAGDTERRRLARELHDVSAHHLTSVVITADAARRLGDSRPELTSEALSFAERTGTETLTALQRLVGLLRDVDRPDPPPMTARIEELIAGFGRLGRPIDAVLPDDLAGPAAEAVHGIVREALTNALRHAPGAAAHVSVLRGEGVLELSVDNAPPRGSAPDGIDAVDGLGSGRGVAGMRERAAAVGGELTAGPAPGGGWRVRATLPDATGPWGPPEGAGRRDVLREQRLADPALVFTATLLPLVFALVTAEEWTGASLRAAVPGLLVVTVLLTAHAVPLLWRRRAPWPAFLGVLATSWLWPAAVAAAALPSRVSEFFAGGALAELLAVYAVAVYGREAARTWPAWGAAAVSLSGTLVATAGADGELSGEGSMWPAAVLMFVPLAVVLAAVFAGLWGAGLAVRRRRLRILAWDDFALAGALWHAERAADAERHRLAAKLRDAVLHPTAALVEQARQGRLEEVAAKARSALAAMRELLHSLGESEEDTGPGLAPAPTAADLDTLCRTVRTAGRDVTLRGLPEAARDLPPAVALSAYRIVEAALGAGDRGPARVTLRRRRDTLRVTVSGVPLAVTGPVAERLKVRVGRGTGHIALEQAGVVRVLLSTRPDPAPAQEEASPSSHA
>NZ_CP049838.1|WP_171398439.1|5312600_5313707_-|CPBP-family-intramembrane-metalloprotease
MTNPLAAPIPALLPEVLPYHRMARVSARHRWWRPVLGTGFVAVACVLVAGLLYGLGSALGAARGYPEAPDGTVEFGPVSGTALDLLAIATALPVVLLAVRWTGRRPAGTVSSVTGGLRWRWLGLCVLAALPVLAVTTGAMLLLPVDDATPSRWAGWEVFGPALAMLIVLVPLQAAAEEYVFRGWLTQAVGAFLRSPWWALVPQAVLFAAAHGWGTPWGFADLAVYGVVAGRLTVRTGGLEAAIGLHAVNNLLAFGVSAAVVDGLKSDDTAADLPWQLAAVDLAGIALYTAAVLWLARRRTPTRTVPAPAPVPPPLPFPAAYPQALAAHAPAPAPWIPVPYADRPDAPALPLGAAPSAPPPGDADRTPR
>NZ_CP049838.1|WP_171398438.1|5311454_5312516_-|YihY/virulence-factor-BrkB-family-protein
MVRTLKPHKRHGERTDDREGETGQDPAAVGPDEQVERQAPDKPTDLPKRSWGAVLKGTLKEFKKDELADRAAALTYYSILALFPALLALVSLLGIVGQSATQAVLDNIQKLAPGAAQDILRNAVQQMQGKGGVGSIMAIVGLVLAVWSASGYVAAFIRSANAVYDIPEGRPVWKVLPVRVGVTVVLMVMAVISALIVVFTGSLARQVGTTLGVGDAALTVWSIAKWPVLVVLVTVMIAVLYWATPNARVRGFRWVTPGSFLALLIWMAASAGFALYVANFSSYNKTYGTLAGVIIFLVWLWITNLAILLGLEFDAEMVRQRAVAGGHPADDEPYVQPRDTRTWDEEDRRRLGS
>NZ_CP049838.1|WP_171398437.1|5310402_5311092_+|GAF-and-ANTAR-domain-containing-protein
MDWERFALKLASMARDLLAQDSVGDTLGRIAASATELVEGCDEAGILILRGTKVETVAATDRLVVDSDRLQERMGEGPCFDSARTAQGERVFRIADFTHEEPRWPAYAPRARALGVGSMMGFLLFTEDEDLGALNLYSRRPGAFTEASETAGWLLASHAAVAFASARAHAQMQAAVATRHVIGEAMGILMGGHRLTEDEAFDVLRRFSQENNIKLREVARRVCEQGGLT
>NZ_CP049838.1|WP_171398447.1|5324176_5324746_+|hypothetical-protein
MFLCLAVSVVHVMLVFLHVAPANTVSKRYSPLINAWVYPFFEQNWRLFAPDPESVNRQILARTARTGSDGSVQVSPWFDLTAVDRSAVEHQPFPSHTAQNMLRRAWAGYVDSHGGDDKARTERALMMQKYLSNIAADRAAAHSSGTFDFIQLRVVALPIAAPGPAAGNRPPTPVENRLLPWWKVTRHGK
>NZ_CP049838.1|WP_171398448.1|5324735_5325872_+|HTTM-domain-containing-protein
MENEAQRTASVGVDRWLADRITAVWELLTGRPVSLYAASVLRIGYGLLYLTFLLREFPHRAEIWGPGSPWTPALARQLFEQTGWLSVLTLSDSRACFELCYVLALVTSALFMLGWRTRVLSVLFAVVVTSFHGRAIFMTDGGDNLVLLMSLYLVLTACGRRWSLDARRHRLKTVRAGGAPTSARSPFACQLRDARATLITVVHNCGMFVIAAQVCFLYGSAGLYKVQGASWGGGTALHYVLNLELFRPWPAISHFVDEHTLAVAVAGYMTVLLQVAFPFVLFGRLKYPVLVMLLGMHIGIAVLMGLPLFSGAMIVADAVFLPDRFYTFLPRLCRRAVRRTDSGRPAPGRAAGPGAVPAQGGPGDSRGSKRRVTFEDQY
>NZ_CP049838.1|WP_171398449.1|5326345_5327119_+|DUF2637-domain-containing-protein
MNHDYADPSFARHDWHSDPYPYAPSAGWHGGPVDGLGSGTPLAPPDSGWDPVEELAYLLQEAVPAEQTVGVVPPPRSESSSGVDFADPMENLAQITAQLPPIRRSSVGHRKIRARKLRLKWLRTGSFVIVAFVAAIVAMVSVFGGMVAYGPLQNISSGTKSGMIPQWPLLVYGPWMVASLSILRTALHQRRALHSWFIVLLFSSVAIMLCVAQAEKTFTGIAGAALPALASLACFQQLVRQITLTLPPRQESPRHRQ
>NZ_CP049838.1|WP_171398450.1|5328443_5329364_+|ABC-transporter-ATP-binding-protein
MIEVRGLTKRYGDRTAVDDLSFTAPAGQVTGFLGPNGAGKSTTMRMIVGLDAPTSGTALVNGKPYAQHRAPLQEVGVLLEAKAVHPGRSAFNHLMALAYTHGVPKRRVEEVIDVAGLHDVAHKRVGAFSLGMGQRLGIAAALLGDPAVVMLDEPVNGLDPEGVRWVRELLRGLAAEGRTVMLSSHLMSEMAQTADRLVVVGRGRLLAETTVDALVEQSEEKGVRVATGEPARLRSLLAAPGVTVTSTGAERLMVSGLDTRRIGQVAAEHQVPLYELVTESVSLEEAFMNLTQDAVEYHSSDTRRAA
>NZ_CP049838.1|WP_171398451.1|5329363_5330200_+|ABC-transporter-permease
MTADTITSPTTTSSPAHPVYRVTGRRVVRSEWSKFWSLRSSWITLGVAVLFLVAIGAIAAALYSPSGPLGGKDAESGAALTLALAGTNLAALAVGALGVLLSAGEYSTGMVRSTFAAVPGRLPVLWAKCAVYGPIAFVTSTVGALVSFGLGSAALHGEKIALSLGDAGVFRCLLGAGLYLGLVGVYGVTVGLLVRNNAGGIAILAGVVLVLPGLTGLLPSSLGDTVSRYLPSNAGQSVMTLHESSDSLVSPGAGMTALLVWAVLLLAGAAYRLRRSDV
>NZ_CP049838.1|WP_171398452.1|5330225_5331632_+|two-component-sensor-histidine-kinase
MDHTRSGHPGRAGTASPSAGSAKPGAALPSEPTLGRGDVRPGPEAVWAHPVMRTLLRVLGRLRAADRRRPWLLDTAVVVLVAAAAPPDLLVHSPGHPVSRPVGAGLPVGVVLAIAAVLVVPLWWRRRAPAEVFGVCLVVCPVMWSLGLGPAAAAVLLIALFDLALHASPRAICWALPATVAGWVLIVVTVIPAASPVAFLFLSTGTGIGAVALGLTFRISRLYLSALRDRAARLEIERDQRARLTAAAERSRIAREMHDIVGHNLSVMVNLADGAAVLTTRDPDRTEQALHLIGDTGRQAMDELRRVLGVLRESSEPEDDSSPRSPQPGVRDLETLLDRVRAAGLPVVYRTVGPVDRLGRGVQLAVFRVVQEALTNTLKHVGPGATADVTVAIEGRLLRVRVADTGSLSRRPPTAHRGDSGHGLVGIRQRASLYDGTVTIGPRDDGQGWIVDVLMDPSASATSGEPTP
>NZ_CP049838.1|WP_171398453.1|5331628_5332294_+|response-regulator-transcription-factor
MTTILIADDQPLPRMGFRMLLDGSPGVSVVGEADNGAQAVRMAAELSPDVVLMDVRMPGLDGIEATRRIVAAGGRTRVLILTTFDLDDYAYAGLRAGASGFLLKDVRPTELLAGIQAVATGDAVVSPRLTRRLLDAHAHDVLAPDAGPRTDPRLAALTEREHEVLVAIGTGWTNAEIAERFVLTESTVKKHVGRVLAKVGARDRIQAVILAYDAGLVAPRQ
>NZ_CP049838.1|WP_171398454.1|5332381_5333740_-|exo-alpha-sialidase
MVLFRSSSATLSAAAFSALFLLSGTPAAVASPNGVGDAAIHEVDVTNMPATKEGQPTVAVNPRNPKNLVFVSTIFPPSPGLEPIDGGCFLAYSNDRGDTWTQVAWPLGTAAPKCGEPSVQFDAKGTVYVDNNQVSSGLAANLLNHNQVAKSTDGGRTWTDPVSTPLLLGGAPKMRVDVATGKVYAVAGAAWEYPSAVSVSADGGKTFSNDSRVIPGPMPCIEVAPGIPLVCGYPGREIAVYGGILVSASQEAGKPVNFHVSRNDGKTWTNTTVNDGTGTPVPAGTGSLVPVPALGAAADPVPWVAADTSHRGRFAVMVPRDSNTLDVYTTPDAGRTWTGPATISTPGAVRPAIDFGANGDLGVMWRTTAGDGFSVVSFDHGRSFSAPVQVNHVTEPVGETGPPGDRWSGIEIAGGYAYVTWADGRNNSSLDSIISRVPLKLYKERTASKSTN
>NZ_CP049838.1|WP_171398455.1|5335021_5335204_+|hypothetical-protein
MATVGWAAVIVTSIGGLIFVLSYLLEQVPPLSDKAVEAIAAVRRLIDAWRGGEQGPPPGM
>NZ_CP049838.1|WP_171402138.1|5336365_5336842_+|hypothetical-protein
MGGSLLTQRGSERAKRLEIELVRDHEEVREARSLRRTCYVELNRDARQFTTALNRHLHVMRERGVAEGDSDALEEAKNAHRDRYSEAQMIAPEEVLRRASVVNQALNKVYGQVKRLERGAPEPGETMETAAQAQYEVWEMLRTMRTAMRYDLGVSHED

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP049838_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049838_12

5790145-5790279

Orphan

Consensus_repeat	Method
CGTCCGGCCTTTCAGGACGAGGGCCGACCAGCCGACGGCGTCGGGCTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049838_12

>merge|NZ_CP049838|12|5790145-5790279|CRISPRCasFinder
CGTCCGGCCTTTCAGGACGAGGGCCGACCAGCCGACGGCGTCGGGCTCGCCGCTGCCCTGTTGAGCGCCGGGCGGGGAAATCCAGCCCGTCCGGCCTTTCAGGACGAGGGCCGACCAGCCGGCGGCGTCGGGCTC

>NZ_CP049838|12|9|5790145-5790279|CRISPRCasFinder
CGTCCGGCCTTTCAGGACGAGGGCCGACCAGCCGACGGCGTCGGGCTC	GCCGCTGCCCTGTTGAGCGCCGGGCGGGGAAATCCAGCC
CGTCCGGCCTTTCAGGACGAGGGCCGACCAGCCGGCGGCGTCGGGCTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049838.1\|WP_171398776.1\|5785004_5785766_+\|TIGR03943-family-protein	unknown	unknown	gnl\|CDD\|274870
NZ_CP049838.1\|WP_171398773.1\|5782942_5783425_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398772.1\|5782467_5782806_-\|YnfA-family-protein	unknown	unknown	gnl\|CDD\|235016
NZ_CP049838.1\|WP_171398789.1\|5799786_5800650_-\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|252734
NZ_CP049838.1\|WP_171398778.1\|5786338_5787220_+\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176191
NZ_CP049838.1\|WP_171398786.1\|5794265_5794979_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398779.1\|5787442_5788240_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378964
NZ_CP049838.1\|WP_171402172.1\|5795122_5795746_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|137458
NZ_CP049838.1\|WP_171398777.1\|5785796_5786204_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP049838.1\|WP_171398783.1\|5791236_5792679_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP049838.1\|WP_171398787.1\|5795985_5797365_+\|MHS-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340927
NZ_CP049838.1\|WP_171398774.1\|5783493_5783967_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NZ_CP049838.1\|WP_171398785.1\|5793376_5793988_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP049838.1\|WP_171398780.1\|5788355_5789465_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274934
NZ_CP049838.1\|WP_171402173.1\|5798862_5799696_+\|PaaX-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225864
NZ_CP049838.1\|WP_171398788.1\|5797361_5798771_+\|prolyl-oligopeptidase-family-serine-peptidase	unknown	unknown	gnl\|CDD\|366030
NZ_CP049838.1\|WP_171398775.1\|5783973_5785008_+\|permease	unknown	unknown	gnl\|CDD\|223773
NZ_CP049838.1\|WP_171398784.1\|5792797_5793181_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398781.1\|5789461_5790091_+\|FMN-reductase	unknown	unknown	gnl\|CDD\|274935
NZ_CP049838.1\|WP_171398782.1\|5790478_5791204_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816

Protein	Function_ID	Function_description	E-value
NZ_CP049838.1\|WP_171398776.1\|5785004_5785766_+\|TIGR03943-family-protein	gnl\|CDD\|274870	TIGR03943, TIGR03943, TIGR03943 family protein. Members of this occur in gene pairs with members of pfam03773. The N-terminal region contains several predicted transmembrane helix regions while the few invariant residues (G, CxxD, and W) occur in the C-terminal region.	3.42347e-49
NZ_CP049838.1\|WP_171402172.1\|5795122_5795746_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|137458	PRK09649, PRK09649, RNA polymerase sigma factor SigC; Reviewed.	6.62368e-44
NZ_CP049838.1\|WP_171398772.1\|5782467_5782806_-\|YnfA-family-protein	gnl\|CDD\|235016	PRK02237, PRK02237, YnfA family protein.	2.54051e-48
NZ_CP049838.1\|WP_171398789.1\|5799786_5800650_-\|SAM-dependent-methyltransferase	gnl\|CDD\|252734	pfam04672, Methyltransf_19, S-adenosyl methyltransferase. This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure Structure 3giw suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22. The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN).	2.18149e-125
NZ_CP049838.1\|WP_171398778.1\|5786338_5787220_+\|NADP-dependent-oxidoreductase	gnl\|CDD\|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	3.03977e-81
NZ_CP049838.1\|WP_171398779.1\|5787442_5788240_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|378964	pfam12833, HTH_18, Helix-turn-helix domain.	1.18288e-13
NZ_CP049838.1\|WP_171398777.1\|5785796_5786204_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	3.68424e-36
NZ_CP049838.1\|WP_171398775.1\|5783973_5785008_+\|permease	gnl\|CDD\|223773	COG0701, COG0701, Predicted permeases [General function prediction only].	8.68672e-41
NZ_CP049838.1\|WP_171398787.1\|5795985_5797365_+\|MHS-family-MFS-transporter	gnl\|CDD\|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.90895e-169
NZ_CP049838.1\|WP_171398774.1\|5783493_5783967_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	9.63152e-12
NZ_CP049838.1\|WP_171398785.1\|5793376_5793988_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.20141e-34
NZ_CP049838.1\|WP_171398780.1\|5788355_5789465_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274934	TIGR04036, family_protein, putative luciferase-like monooxygenase, FMN-dependent, CE1758 family. This tightly conserved subfamily of the bacterial luciferase-like monooxygenase (LLM) family, with members showing > 60 % pairwise sequence identity, includes proteins from both species with and species without the ability to make coenzyme F420. Therefore, the like cofactor is FMN rather than F420. The presence of three members in Kineococcus radiotolerans SRS30216 and two in Saccharopolyspora erythraea NRRL 2338 suggest closely related (subfamily) rather than exactly conserved (equivalog) function. Gene neighborhoods around members are not conserved. [Unknown function, Enzymes of unknown specificity].	0
NZ_CP049838.1\|WP_171402173.1\|5798862_5799696_+\|PaaX-family-transcriptional-regulator	gnl\|CDD\|225864	COG3327, PaaX, Phenylacetic acid-responsive transcriptional repressor [Transcription].	1.17632e-37
NZ_CP049838.1\|WP_171398788.1\|5797361_5798771_+\|prolyl-oligopeptidase-family-serine-peptidase	gnl\|CDD\|366030	pfam00326, Peptidase_S9, Prolyl oligopeptidase family.	1.77332e-05
NZ_CP049838.1\|WP_171398783.1\|5791236_5792679_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.3e-43
NZ_CP049838.1\|WP_171398781.1\|5789461_5790091_+\|FMN-reductase	gnl\|CDD\|274935	TIGR04037, predicted_flavoprotein, LLM-partnered FMN reductase, CE1759 family. This family represents a distinct clade within pfam03358. That family includes enzymes such as the NADH-dependent FMN reductase MsuE. Members of the present family regularly co-occur in genomes, typically as gene pairs, with members of TIGR04036, a probable FMN-dependent member of the bacterial luciferase-like monooxygenase (LLM) family. At least one member, RF\|YP_001509627.1 from Frankia sp. EAN1pec, is fused to the LLM protein. The function of these gene pairs is unknown.	3.35476e-89
NZ_CP049838.1\|WP_171398782.1\|5790478_5791204_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.87213e-83

>NZ_CP049838.1|WP_171398781.1|5789461_5790091_+|FMN-reductase
MRLVVVSAGLSVPSSTRLLADRLAAATAGRTSAGADVEVEVVELRDLAVEIAHNFTNGFPGRKLAAALAAVTAADGLIVVTPVFSASYSGLFKSFFDVIDPDALAGKPVLIGATGGSARHSLVLEHALRPLFSYLRAVIVPTAVYAASEDWGAEGLPERIERAAGELATLMTGLSTPSGPAKTEKAEKAEKDEFTVVPFADQLAALAAR
>NZ_CP049838.1|WP_171398780.1|5788355_5789465_+|LLM-class-flavin-dependent-oxidoreductase
MQFGIFSVGDVTPDPTTGRTPTERERIKAMVAIAQKAEEVGLDVFATGEHHNPPFVPSSPTTMLGYIAARTERLVLSTSTTLITTNDPVKIAEDFAMLQHLADGRVDLMMGRGNTGPVYPWFGQDIRQGINLAIENYALLRRLWREDVVDWEGKFRTALQGFTSTPRPLDDVPPFVWHGSIRSPEIAEQAAFYGDGFFHNNIFWPADHTKRMVELYRARYAHYGHGTPEQAIVGLGGQVFMRKNSQDAVREFRPYFDNAPVYGHGPSLEDFTDQTPLTVGTPEQVIEKTLKFREYAGDYQRQLFLLDHAGLPLKTVLEQLDLLGEEVVPVLRKEFAVGRPAEVPDAPTHESMLKAAQAGKATQEGVNVA
>NZ_CP049838.1|WP_171398779.1|5787442_5788240_-|AraC-family-transcriptional-regulator
MATPRRDTRGIVDAADFLARVRFRRPEPAPPLRPYVEHYWLIDWDLTEPYVSHVVPHPAVHLVFQRFEGQEPFVEIAGVQQGLFTQKLEGRGRVCGVKFRPGGFRPFAPEHPVSHWTGRRVHLTGTDPAPVLDPAGEEARVAALDAHLLAARIPRPDPQADLAMTLVDRIRTDRAIRKVADLASDEGLSVRLIQRLFAAYVGVGPKWVILRYRIHEALERAEAEQTVDWAALAADLGYADQAHLVRDFTTTVGVPPATYARHRSS
>NZ_CP049838.1|WP_171398778.1|5786338_5787220_+|NADP-dependent-oxidoreductase
MRAAVVRTFGGPEAVEIVDAELPEPAARQVRIKVAAAALNPVDAGVRSGVFGGAGKQVGLGWDVAGTVDAVGVASAWNVGEEVVALDYGMVKPLGTHAEYVVVDADAVALAPASVDAVHAATLPLNALTAAQALDLLALSPGDSLLVTGGAGAVGGYAVQLAARRGVTVAALARAQDEEFVRSLGATRFPGGEGRFDAVLDAAVLGSEALALVRDGGAYVGVIPQAQPASERGVRTEAVEVSADGARLAELVRSVDAGELTLRVAETFTLEDTAKAHARLAEGGVRGRLVLVP
>NZ_CP049838.1|WP_171398777.1|5785796_5786204_-|helix-turn-helix-transcriptional-regulator
MATTTAAQRREQARTEYDAFLRDCPTNQLLDRLSDKWVSLVVSALAPGPQRYSDLARRIAGVSPKMLTQTLRTLERDGILTRTVTPSVPVRVDYELTPLGSNLALLLTAVKNWAEIHFDEVHAARRRYDTDSTDV
>NZ_CP049838.1|WP_171398776.1|5785004_5785766_+|TIGR03943-family-protein
MRRFAQVGLLVLGGLGLLHTSLFTDEYLRYVKEGMRPLLVASGVLLVVLGVAEAWAAPPKEEPGEPGHGHEGHGHEGHGHDHSGVPRVAWLLFLPVLSLLFYAPPALGSYTASREPAKAVAVQEDAFDPLPATSPLPITLTDFTQRVQQDRSRAIRGRAVVMTGFVTPAPRKRDGWYLTRIIVSCCAADASSVKVLVQGIAAPKADTWVNVTGTWQGSGTLGTASATVALDARGVQKVRKPSNAYMDALPLTS
>NZ_CP049838.1|WP_171398775.1|5783973_5785008_+|permease
MQETDVRPSAEAAEGVRAADARPAGALPRHWPLLLLGAAVVPGVLLVLVGRSLDAPAMQAWRTVCLAVTVQALPFLLLGTALSGAINAFVPARVFSRLLPKRAALAVPVAGMAGVVLPGCECASVPVANSLIGRGVTPAAAFAFLLSAPAVNPVVLTATAVAFPGSPEMVVARLLASLVTAAAMGWLWLWLGREEWLKPTVVRHTGHVPGRSRFTEFRRGFQHDFLHAGGFLVVGAMAAATFNVAVPRTLLDTFAGSPWLSVLFLAALAIVLAVCSEADAFVAASLTGFSPVARLAFMVVGPMVDLKLIALQAGTFGRAFALRFSAATAVVAVVCSAVIGGVLL
>NZ_CP049838.1|WP_171398774.1|5783493_5783967_+|winged-helix-turn-helix-transcriptional-regulator
MSGNVRSRLLDELGVVSRRYAAAYALFNQALADRLGLHPTDLQCLNLLMLEREPVTTGRVAELTGLTTGSATRLVDRLEKAGYVVRERDAADRRRVLVVTVPERIAEFTRMWERLGGDCMPLFEDLADSELAVIVRHMRRTVEFGAEQVARLREGRV
>NZ_CP049838.1|WP_171398773.1|5782942_5783425_+|hypothetical-protein
MRWMRGLAVWGAVLAVGVGVAPARAAGTAGEATEADLSYHGSAVMRGGRVDVGLTPRNHGPADVSDSTVRLRWSVPLAAGAQRLPAGCARTGRQEVVCRTGALAADGLGERIELRVWLRGRPIEVTMAVDTLWGGGAVDRNRSNDRQQVLVLDTGDAYFF
>NZ_CP049838.1|WP_171398772.1|5782467_5782806_-|YnfA-family-protein
MFVLRSAALFVVAALFEIGGAWLVWQGVREHRGWLWATGGVLALGAYGFVATFQPDAHFGRILAAYGGIFVAGSLLWGAVADGYRPDRWDVTGALVCLAGMAVIMWAPRNGG
>NZ_CP049838.1|WP_171398782.1|5790478_5791204_+|response-regulator-transcription-factor
MPPTVLLAEDDRAIRNALERALALEGYRVTAVADGVEALAHAHKNPPDVLVLDVMMPGIDGLQVCRVLRAEGDRTPILMLTALVETADRIAGLDAGADDYVVKPFDVEEVFARLRALLRRTTPDAAPEAAVPVLDAPKRSTERDVEAAGLRMDPQARRAWRGGRELELTRTEFELLELLARNAGIVLDHSTIYDRIWGYDFGPGSKNLAVYVGYLRRKLDQPGAPQLIHTVRGVGYVLRED
>NZ_CP049838.1|WP_171398783.1|5791236_5792679_+|HAMP-domain-containing-histidine-kinase
MSRLRRLLSRPRPKLVSLRTTFAVSFAAVTAAVTVLVGVLSYSAAARLVRVDQESVFDEVVQDLRDEVRDHRMAPEDFSSSAPGHDIVRPARTDVQVLGADGSVVDSGSPGLPVVSADHTIAAAAAAGRITEHKDVDVGSDVYRIATVSLGGGRGAVQVAQEFSDTEDLLRALQQRTLILMIAVVTAAGLFGWWLARRITHRLVILTTAAEDVARTRRLGVQVPVTGHDEVGRLGRAFDRMLGRLAQSEEDQRRLVQDAGHELRTPLTSLRTNISLLRRIDELPPDTRDELVADLTQEARELTDLVNELVDLAAGQSDTEPPRRLDLADIAEEVAGLARRRTGRPVLIRTSGDTTLYGRPAMLQRAVSNLVENATKFDRGGGAPVEIAVTGPSRPGVVRVEVLDRGPGIAETDLTRVFDRFYRAADARSLPGSGLGLSIVREVALTHGGAPFAFRRAGGGSVIGFTVGGGLPDGPGADGG
>NZ_CP049838.1|WP_171398784.1|5792797_5793181_-|hypothetical-protein
MRNRLAIIAAAAVLPMTAAISLAAATQAGADPNSKTVVVTGAVEDCPNGTPPNKVTITTTKSKEVRTDKTDVDDTGEYSVKFTKIAKAGDNGTAKVTCTGDSYTDTFKIKRPTDPNSLTQEQDIESP
>NZ_CP049838.1|WP_171398785.1|5793376_5793988_-|response-regulator-transcription-factor
MSVCAERVRIAVIGDCPVFRHGISNLIGAAPDLHLVAAAPSIESADGSLRGAQVVLMDLQQSAPRLAATVTKLRRRGHAVLVVSSSPYLDAVQAIQAGASGYLSRQAEANEMLTAIRTVGSGRSYVSAPASHLVGPAPRFTDREQEILRLLANGSTDHEIAAALGISKHTVHSHLDRIGEKTGSRRRPDLTRIAVEHGLTSLE
>NZ_CP049838.1|WP_171398786.1|5794265_5794979_+|hypothetical-protein
MTAGWCTRTLRAALFAAVCVLLAALGHVMMSGSEVPAWALAAGVAVTGIAGWCLAGRERGLALIVTVVVAAQTALHSAFSLAGPESGDAASAGMGVMGMGSMRMDSMDMDMGHMAHVSHLDHASHTGHMGHMSHMSHVGEAAGEGGSSSFGMLAAHLLAALLCGLWLAHGEKAAFRILRAVAGRLAAPLRLLLALPVTPDRPRVRFRRRGSARAPRLLLLTHAITTRGPPSGTAAAV
>NZ_CP049838.1|WP_171402172.1|5795122_5795746_+|sigma-70-family-RNA-polymerase-sigma-factor
MKAPQAPQAPQASHASQAALDESITAWALAARAGDADAVERFVRALHRDVLRYVSHLCADPQAVDDLAQDTFLRALGSLHRFEGRSSARSWLLSIARRAVIDSYRYAATRPRLSDVPDWQLAAERAQPRDLPGFDDGVVLLDLLASLPAERREAFVLTQLAGLPYAEAAEASDCPVGTVRSRVARARATLVDLLEEEPAGEPAPLAA
>NZ_CP049838.1|WP_171398787.1|5795985_5797365_+|MHS-family-MFS-transporter
MPPSPVASPSPSPSTSTSAERTRQLRVVAASGLLGTAVEFYDFLVYGTVAALVFGELFFPGADPAVGTIAAFGTFAAGYVARPLGGILFGHFGDRLGRKSMLLLTMGLMGGASFLVGLLPTYDTIGVWAPVLLITLRVVQGIAIGGEWGGATLMVVEHAGERRRGLWSSFTQMGAPLGSLLSTAVVALVVALPKDEFAAWGWRVPFLLSVVLLGVGLFVRLKVVESPLFTEVKKDRAESRLPILDVLRRPRPVLLACCVGIGAFTAQSLLTSYLIAYATGIGYARPQVLTALTVSAAVALVVLPCASALSDRVGRRPVVLAGALASAALAFPVLALVDSGSPGLLILAVVLGHGIAQSTMYGPLGALLTEMFGTRVRYTGASLGYQGATLIGAGFSPMIAGSLVAGSGNSTPVSLLLCGGAVVTAVTVLFVRETSRTSLADTADPAEGSDAPHTQEITA
>NZ_CP049838.1|WP_171398788.1|5797361_5798771_+|prolyl-oligopeptidase-family-serine-peptidase
MTPPTPTPTPTRSRTRTAWAAAVLLAVTALPASTAAAAADTSHVEGRLPSGAAYMMDVPAGWNGTVLLFSHGYTSGPANPAQDAPDAATKTLLLEKGYALVGSSYATTGWAVTDAVPDQLAALAAFTDRFGAAGRTIAWGRSYGGLVTTAIAERHPDRIDGSVALCGLVQGGVANWNNTLDPAFAVKTLLAPGSDVPLVDLADQTAATEAANTLTAAVDSAQTTAAGRARIALAAALHNIPVWNQPTQPRPAATDWDAQQANQYDAVKGLLKIAAFNRRQEAEVRAGGNMSWNTGVDYAKLLGRSSVRKEVTELYRKAGLSLTADLTTLNRAPRIAADPAAVAWMSGTSSFTGELAKPQLSVHTIGDALVPVQTESALRRAVTAAGSSALLRQAYVDNAGHCTFSPAEQLAALHTLEDRLTTGHWRGTDPAALNSRATAADPTTPTRYVPYRPTPYLRPYDLAHPADRR
>NZ_CP049838.1|WP_171402173.1|5798862_5799696_+|PaaX-family-transcriptional-regulator
MPDTSDGGAPQLRPQSLMLAFFGNHVLEEGDLCVYSGSIIDVLGRVGVGEQAVRSTLTRMVSRGLLRRQREGRKMYFGLTEQATRVLRDGRTRIWREGAVNDDWDGDWTLLGFSLPESRQRERHDLRSRLAWSGFGALYSGLWIAPGKVDVAAVVAELGLTAHVKIFHASADEATDIGLMIRDTWDLESVAARYVSFDKRWTAHLNAGPGEDPIGTRLRLVSEWLWTIRTDPRLPSRHLPPDWPARPAQDTFRRVAGQTETPAHHLAHRLLETTPLR
>NZ_CP049838.1|WP_171398789.1|5799786_5800650_-|SAM-dependent-methyltransferase
MTSPLSGSSDAGSGGTGSPFLKIDTSKPHPARMYDYFLGGKDNYEVDRDAAEQFIKAAPEVRDGVRANRHFMHRAVRHVVAEGGVRQILDIGTGLPTEPNVHQIAHSIAPATRVAYVDNDPIVSTHSMALMADADTDSGTDAHTSVVLADLRDPRAVLDHPDVRKIIDFDEPVALLLVAVVHFLADADDPDAVVATLRDALPVGSYLVLSHATGDVHEDRREDAASVYNKASASLNLRPHARVLDLFGDFTLLDPGLVPVPDWRPEEPPKRDAPPIGIYGGVARKNG

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP049838_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049838_13

5979951-5980481

Orphan

Consensus_repeat	Method
GGGNNCNTGNGNNGGCGGGNCTGCGGGC	CRT

9 spacers

The CRISPR arrays of NZ_CP049838_13

>merge|NZ_CP049838|13|5979951-5980481|CRT
GGGCACCTGAGCAGGCGCGGCTGCGGGCTCGCGTGCCGGCGCGGCTGCGCGGCTGCGCGGCTCCGCGGCTGCGGGCACCTGCGCAGGCGAACCTGCGGGGCACCTGCGCGGGCAGACCTGCGGGCTCGTGTGCGGGCAGGCCTGCGGGCTCGTGTGCCGGCGCGGCTGCGGGTTCCTGGGTGGGCGGGCCTGCGGGCGCCTGCGCGGGCGGGCCTGCGGGCTCGTGTGCCGGCGCGGCTGCGGGTTCCTGGGTGGGCGGGCCTGCGGGCTCGCGTGCTGGCGCGCGGCTGCGGGTTCCTGGGTGGGTGGGCCTGCGGGCGCCTGGGTGGGCGGGCCTGCGGGCGTGTGCCGGCGGGGCTGCGGGCTCGCGTGCTGGCGCGCGGCTGCGGGTTCCTGGGTGGGCGGGCCTGCGGGCGCCTGCGCGGGCAGACCTGCGGGCGTGTGCCGGCGGGGCTGCTGGTTCGTGTGCCGGCGGGGTTGAGGGCGCCTGGGTGGGCGGGCCTGCGGGCGTGTGCCGGCGGGGCTGCGGGT

>NZ_CP049838|13|3|5979951-5980481|CRT
GGGCACCTGAGCAGGCGCGGCTGCGGGC	TCGCGTGCCGGCGCGGCTGCGCGGCTGCGCGGCTCCGCGGCTGC
GGGCACCTGCGCAGGCGAACCTGCGGGG	CACCTGCGCGGGCAGACCTGC
GGGCTCGTGTGCGGGCAGGCCTGCGGGC	TCGTGTGCCGGCGCGGCTGC
GGGTTCCTGGGTGGGCGGGCCTGCGGGC	GCCTGCGCGGGCGGGCCTGCGGGCTCGTGTGCCGGCGCGGCTGC
GGGTTCCTGGGTGGGCGGGCCTGCGGGC	TCGCGTGCTGGCGCGCGGCTGC
GGGTTCCTGGGTGGGTGGGCCTGCGGGC	GCCTGGGTGGGCGGGCCT
GCGGGCGTGTGCCGGCGGGGCTGCGGGC	TCGCGTGCTGGCGCGCGGCTGC
GGGTTCCTGGGTGGGCGGGCCTGCGGGC	GCCTGCGCGGGCAGACCTGCGGGCGTGTGCCGGCGGGGCTGC
TGGTTCGTGTGCCGGCGGGGTTGAGGGC	GCCTGGGTGGGCGGGCCT
GCGGGCGTGTGCCGGCGGGGCTGCGGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049838.1\|WP_171398915.1\|5982998_5983694_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398919.1\|5987859_5988273_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398910.1\|5976335_5977550_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398906.1\|5972133_5972874_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398909.1\|5975121_5976309_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398914.1\|5981794_5982988_-\|phage-tail-protein	unknown	unknown	gnl\|CDD\|227699
NZ_CP049838.1\|WP_171398905.1\|5970543_5971443_-\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|376556
NZ_CP049838.1\|WP_171398907.1\|5972873_5974019_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398917.1\|5984518_5984728_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398904.1\|5970267_5970528_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398918.1\|5985044_5986139_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP049838.1\|WP_171398913.1\|5980517_5981798_-\|tape-measure-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398920.1\|5988749_5989250_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197775
NZ_CP049838.1\|WP_171398916.1\|5983722_5984400_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_054238759.1\|5970010_5970271_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_054238774.1\|5986711_5987002_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398911.1\|5977623_5978940_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398908.1\|5974055_5975078_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171398912.1\|5978944_5979865_-\|phage-tail-family-protein	unknown	unknown	gnl\|CDD\|368574
NZ_CP049838.1\|WP_171402193.1\|5989478_5989790_+\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791

Protein	Function_ID	Function_description	E-value
NZ_CP049838.1\|WP_171398918.1\|5985044_5986139_+\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0.000192583
NZ_CP049838.1\|WP_171398920.1\|5988749_5989250_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	0.000160666
NZ_CP049838.1\|WP_171402193.1\|5989478_5989790_+\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	0.00230101
NZ_CP049838.1\|WP_171398914.1\|5981794_5982988_-\|phage-tail-protein	gnl\|CDD\|227699	COG5412, COG5412, Phage-related protein [Function unknown].	1.28033e-12
NZ_CP049838.1\|WP_171398905.1\|5970543_5971443_-\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|376556	pfam01510, Amidase_2, N-acetylmuramoyl-L-alanine amidase. This family includes zinc amidases that have N-acetylmuramoyl-L-alanine amidase activity EC:3.5.1.28. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala). The structure is known for the bacteriophage T7 structure and shows that two of the conserved histidines are zinc binding.	3.98825e-19
NZ_CP049838.1\|WP_171398912.1\|5978944_5979865_-\|phage-tail-family-protein	gnl\|CDD\|368574	pfam05709, Sipho_tail, Phage tail protein. This family consists of several Siphovirus and other phage tail component proteins as well as some bacterial proteins of unknown function.	4.25195e-11

>NZ_CP049838.1|WP_171398912.1|5978944_5979865_-|phage-tail-family-protein
MAEITTTAYTDDVAPGSLITRDGQMQWAGLLMGPGTPYEIDRGGLSGWEDLPEYDSSDADHPTAHGAWPGARYAKPRKVGGTVWTVPAQDDTASSLAATRVLRQALLLGDAERWLAVRLHGETLAVRARVSQRVLAADRTYTTQGVSRASVQWYATDPRRYSVTEQTAVTGAPQPESGLTWPLTWPLYWGQAASTGDVNADNGGSAPTHPVITFTGPCANPTVTDRTSAQRLRYEIALASGDELVVDTSAGTVTLNSTASRRHTAAADSSPEELFAFAPGRAQLAFRPDTYGTGAQMTVRWREAEW
>NZ_CP049838.1|WP_171398911.1|5977623_5978940_-|hypothetical-protein
MTVRAAWLTETGQTREDTRVTLSGLLTPNALVAENIPLKARGGIVPGGFALSGATGGMTLTIGTGRAFVQGGRTNQGTYPVAVTEPESLTIDDGDPTHQRIDLVELVVQDSTYDGTADTVARVRLVKGTPAATPQQPVGPDGSTLPLYRILVPAGASAGSGGLAWDSAVTNLRYATVALGGIVPAAGFSGAYAGQYRDNAGVLERWDGTAWVAYPKGVGGIPPAGTLTAGSYAGQYQEDPTGPLQRWNGSAWVAYPKSVGGIAPSGTVATGGYPGQYREDSAGLLQRWNGSAWSYAEGRTTLLLSVSQISMQSMAHGTWTQVSMPSTDVDDAAGWSGSNTYTVPRAGWWRVAANVSWSTESTSGSRGARLHLNGTGVPRATWLVGAGPAITSVGGTALFRCAAGDKLALYAFQNSGSAVSTLGGSGYSTNLTAEWIKS
>NZ_CP049838.1|WP_171398910.1|5976335_5977550_-|hypothetical-protein
MNLRSSWVAETGQTREDTRLTQLGATTPANPLDVRSGILPGSYDGQYRLSGFWMEGGAGTMTATVHEGRAVVQADSNQGAYPVTLAEPISLTFADGDASYGRIDVVVLRVYDDLYDDSGFTKAAVEIVRGTPAATPVVPALPEIALPVYQVAVRAGISAGKGGINWSTDVTDLRTPTVAVGGILPVYGDTGNGAYPGQYRDSGGALQRWDGSAWVSYPSALGGIAPSGTVTTASYTGQYRDSPAGLQRWNGTAWVTYQPVPTWTNYTPVWRCETGAAPTLGNGTLAGAYVKTGTVVTFRIYLKIGSTTNLSAQDTNGDWTFSLPATPVSTAWKLDGRVLNAEAFDDSAVLMYQGSGLLAVANGGVVRSLRDTLKTGTSPWDKSAPFAWAVNDILSIHGTYESAS
>NZ_CP049838.1|WP_171398909.1|5975121_5976309_-|hypothetical-protein
MTVRSAWLSPDGQSREDTRVTQIGAVTPVTDIKGRSGVLPGSENGLYRVTGLWLNGTTGGMTATVGVGRAVIQTSVARGAYPVAVTEPVPLTFDAGDPQFGRVDLVVLRIYDDDYDGSDRTEAAVEIVKGTAAATPVAPAAPDASLVLFTVAVAKNAGAGSGGIDWDNARVDLRPTTVPLGGILPTRSDDTAPGGYPGHYRDVNDTLQRWSSTAWVPYPKGVGGVVPAGVLATGGYVGQYRDSSLGQLQRWNGSAWQPAVPGPAFVQSLDAGTTASTTYTAALASTTVTALTLNFTAPPSGAVIIGLGARMSSGGETAQAHMSPQVTLGSTVIWAADDERAASGSGAVSKSTSTQLRLNSLTAGSTYTVTAMHRSSNASYTCAFDNIFLRVDPIA
>NZ_CP049838.1|WP_171398908.1|5974055_5975078_-|hypothetical-protein
MPVRSGWLSPDGQSREDTRLVSLGALTPTSPVATRSGVLPGSSDGASRISGFTLTGTANSMSGTVSPGRAVLQSTDVRGAYPIALTEYLPVTFADGNAQYNRIDLLVLRIYDDAYDGSGRTEAVVEIVPGTAAAAPTVPAAPGLSLPLYEVTVPANASAGTGGIAWASALVGRRTATVGVGGILPVTTDTSNGAYPGQYRDLNGVIQRWSGTAWADYQPPLVVETTNTGITAQGNWSLSWFGARRTRGVCSFTVGLTRITSALTATAAGTTNPGNVGDELICALPAGWRPVVETYASASDGFADGAVRIAADGSVQLISWSTSGVIQVGNVLRFSACFVL
>NZ_CP049838.1|WP_171398907.1|5972873_5974019_-|hypothetical-protein
MTTTTTPYRAIFCDLRTDDTIDILPLRDVTVDDYIGKAGSLSGTVPVPNAEMAARVRRIEEGRTSVYLQRGNDLWWGGIIWTSTLQSDDRGVLTLGIQAATFESYAGRRRIRQDLTFSGSDDQLEVARRLWRHLQTGELVDDGTPPAPTGGDIGVTFGEDLSGVTRSVSYRDGDETVYLEAIDALAALENGFEHYIAVYRDPVSGTRVRRLRLGSPKITTGSTDLVMDRPGTILSYTFPRDATRGGTTARARGATDNTNQAVESRPLFADADIPDGEALIKVGYPRIDLASDHNDIASTTILRSLANAELAEGTGAVVIPEISVRLDDLVPSALLGRSVRLRITDEWWTEGLDARYRIIGVKVSPAQRGRPDTAELYLEEA
>NZ_CP049838.1|WP_171398906.1|5972133_5972874_-|hypothetical-protein
MPQLPEDIIDRLTQMERRIQQLSTAVNTRPALNTITGGEVEIKDGTLKVTDGGTLLVQRPGSTDTMFRVGSWKDAEYGLEIHRQTGSLAMTLFNGDGSAGSLQPLRIYDNGNREIFSDDVNSGGLARPWLAMLPPQDSTQTRWPQTTSTSWATIAMSYNPVWQPKMRLRLSTAASSGAAGQVRVLVNSAQWGPAVAAGTEFDYTDLISTTFSSVYTTTLKVEIQAIVTSTSGTVYATPVLMHGRQS
>NZ_CP049838.1|WP_171398905.1|5970543_5971443_-|N-acetylmuramoyl-L-alanine-amidase
MANPLSADALVSALRAEGVTVVEHSGWRTNNRNQKGSWGPVNGVIVHHTVTSGTSNSVSLCFNGHSALPGPLCHGVIAKDGTVHLVGNGRANHAGSGDGDVLRAVVAEKALPAPNENDTDGNVHFYGFECVNLGDGKDPWPDVQLEAMVRASAALCRAHGWSAASVIGHKEWTSTKIDPRGFAMADFRARVATRLGKPTTPSTGTGTGTGTGTGKPQYQPFPGAAWFRKNPKSAIVTALGKRLVAVGCSAYTSGPGPQWTEADRLSYAKWQRKLGYTGSSADGWPGAKSWAALKVPYSS
>NZ_CP049838.1|WP_171398904.1|5970267_5970528_-|hypothetical-protein
MSEAAKRTLRTVLQTAVGLCVLLPTVVDAAGIPGTLPWVAAALTAAAGVTRVMALPAVQTLLPSWLRTDTTADAGDGEKPSEKSAA
>NZ_CP049838.1|WP_054238759.1|5970010_5970271_-|hypothetical-protein
MNEPFSDPAAVALELERLRGTVEAGFARVDGSLALLVQRSDQTDKQIADHEQRLDALERSRWPLASIGALAALATVAVTAWELTGR
>NZ_CP049838.1|WP_171398913.1|5980517_5981798_-|tape-measure-protein
MSTAALPAGGGVADLFAGVAPALQAFRSRLGQNTATARSLVGRIRSAATGVDAVRSAASQGATAVRQVKAGADAASRSVAKTGRTATEAASGIKSAGTRAKGAGKPLGALNSAFGGVLAIVGALIEASGVLGDLMGAFGTAMTIGSGVMLIINALTRANPIGFVTGLLLPVAGWLIDLALNSETGQRLMEQLATLVLKYVEGYLTVMTPLLKGIASAVNTYVTGYLGVITTALTAIVGTGFAVLKALTTGDTRALSGRVSSVWRGFKDAVRPALEWITRDVPRMFTRIKEATSRTLDAMGKFVTTGTQTVAGVVKGPIQGLIAFANWVIDGLNSLSFSILGKKFGIHLDKIPMLAEGGIAVPGASRGAGRVLPLTALERQRALARRHRTPTPPSPYRVKEFHESAGTGARGTAEDLLFLAAAHACA
>NZ_CP049838.1|WP_171398914.1|5981794_5982988_-|phage-tail-protein
MSLSSAASRAANSLQQFKAQATGVATATQNLSRAAQSGKGEIGKLRSASQETTKQLKDLRTASDQAEKSLGKAGKTGSSAGTNLGKYETGAGKAAKGQDKMNKSMKGNFFGMLMDLLAPLIEKVVEMATKSKTMQKVLKTAFDVIKSVISTVMKAIGPIMKNAAKLIKSVWDGIKKAISAVVKAVATVIKTYVAIWKKVITTALNAIKTVVSSVWKGIKAVISPVVNWVKSAIPNAFKAVKDKLSSIWGGLKGIAGRAFDGIKSAVKGPINAVIGIINRAIGALNGIKVSIPGWVPGVGGKTFGVSLPRIPMLATGGVVMPRSGGVPAILAEAGEAEAVLPLSKLDRLLRRAAAQGSAYAGTSGSGGALHIEHYYAAESSSPQRTADALMFLAKARG
>NZ_CP049838.1|WP_171398915.1|5982998_5983694_-|hypothetical-protein
MGRDLKKIDEDLKNLEDNTTTSIAGINTRLGVHTTDIAGINTKLGTHSTDITKLQQSYKGLRTTHSGISTSLSWMSNSIAAHTNGLTGLAASLTLLTVGLSIFKIDEKGITFLGATREFPWKKHIDELQKWRLMESQTQKESREKKERREKVVDDNFQHIEKLKETEQTVEKLKQRLLVVRDAADAERRRLEANPRMRTDRGIDDPVPLVRGVASEVTVLRRALRELTAAL
>NZ_CP049838.1|WP_171398916.1|5983722_5984400_+|hypothetical-protein
MPSDDVRVVLAVPTSWNWYFEPKRKGSIAWFAERALRIADGFHPGRGVDVFLYGESKDPEESTDSNYGDAGTEVIRTRLERGSLSEWIGDWAVRPNMDRGLFEDSGPASKVEERLGVGDAPWYGRPLPAVRAIGEWNAGHEGTTLVLFWLDRMTQAEEMAQFIGRYDDDATFWQLFGDADDIHYSFWTRQGMHQGKVLPQLNFHIGRRWSRRAILRGFSRWTKNG
>NZ_CP049838.1|WP_171398917.1|5984518_5984728_-|hypothetical-protein
MVTGTSNSPKQPIDTYTRLAHLLHTTPPDREALLDRVYEELLARESRAYAAGWSDALTEARRARGGRRP
>NZ_CP049838.1|WP_171398918.1|5985044_5986139_+|hypothetical-protein
MGPGDESKAYGVDGDASNVRREHVIDWLEQAPDLPHLIARVSELVLRLGHEPDDLVVLPRSELDRRELAAYSAGWADVVDEQLPAIRRAYEERITAAYLQGQEDARTGHRPRRARRAEGEHEHERGGEVIPLPYVELLRPPSAWTRVEERGERERSVADGTPVPTPPPAGETDGGEEAPYGDPGTANVVGTTSPTGPTGASSPARGSHEGDRDVDDEVGGAGGAEAGSGAEGDILLSAREVRGKRVTPSDRRPVVMRNGRPSVPPLALPGEIGATGRERARRPDGSGTAERPPQEQPERADVERTDDVEQPEPVEPVEPADPQGARDEPRRRLLSDKARALADELEGRAGGRRRDEQNGPPGSR
>NZ_CP049838.1|WP_054238774.1|5986711_5987002_-|hypothetical-protein
MARFDVNAARAQRLEALGRTWSFELDDESFTLPTELTRATAKALRELDDNDVDGLLGLLMGEQQFARFERHEVTMQDIAAILEAYGKETGLGLGEG
>NZ_CP049838.1|WP_171398919.1|5987859_5988273_-|hypothetical-protein
MTTPTPPSAFPDVEALVVDILEADSALSTALVAVEPPANFDGTTAAVLVNRRGGAWIGELHVDQPLIELEVYGPTKQAAHVLANSARRALLAAAGNRYGTNLITEVEEQDGPRWLPDYLYSAANRYVGVLKVFLDVY
>NZ_CP049838.1|WP_171398920.1|5988749_5989250_-|helix-turn-helix-transcriptional-regulator
MTNQGLDAFAAWVEDLMRERGYDIDSPRGGGKSRIADEAGVHRAAVTRLLQRQSMPDLETTRRLARVLGVPVRDMLIRSGRLTAEELADPHDYLASPAPGADFGRRPTLEEVADLLGVPAERREMFVRVVEQFLPSEAEAEVAHVREVREDRRVLVETAAAAPTAD
>NZ_CP049838.1|WP_171402193.1|5989478_5989790_+|WhiB-family-transcriptional-regulator
MPETSSCPSAPGWQSAAACTGLSPRVVFSKKAKVAAPALRACAGCRVRRACEEAVAPADNWFDGVCGGRLWRSGRPVPVPAHLLPPAPAVGLAHLPAQGDTRG

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP049838_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049838_14

6067361-6067500

Orphan

Consensus_repeat	Method
CACATTAGGGGCGGACACTCCGTGATCCATCCTGGAGCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049838_14

>merge|NZ_CP049838|14|6067361-6067500|CRISPRCasFinder
CACATTAGGGGCGGACACTCCGTGATCCATCCTGGAGCCTTCCGCAGTGGCCACTGTGGTGGGCTCCACCTGTTTCGGATGGTGAGCGGCCGCCCCCAACCACATTAGGGGCGGACATTCCGTGATCCATCCTGGAGCCT

>NZ_CP049838|14|10|6067361-6067500|CRISPRCasFinder
CACATTAGGGGCGGACACTCCGTGATCCATCCTGGAGCCT	TCCGCAGTGGCCACTGTGGTGGGCTCCACCTGTTTCGGATGGTGAGCGGCCGCCCCCAAC
CACATTAGGGGCGGACATTCCGTGATCCATCCTGGAGCCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049838.1\|WP_171398966.1\|6058192_6058900_-\|ester-cyclase	unknown	unknown	gnl\|CDD\|377824
NZ_CP049838.1\|WP_171398978.1\|6081127_6082735_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP049838.1\|WP_171398972.1\|6069170_6070877_+\|glycerol-3-phosphate-dehydrogenase/oxidase	unknown	unknown	gnl\|CDD\|223651
NZ_CP049838.1\|WP_171398977.1\|6079382_6081035_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP049838.1\|WP_171398974.1\|6072319_6074542_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP049838.1\|WP_171398970.1\|6064190_6065696_+\|IMP-dehydrogenase	unknown	unknown	gnl\|CDD\|376340
NZ_CP049838.1\|WP_171398965.1\|6056461_6058087_+\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
NZ_CP049838.1\|WP_171398969.1\|6060666_6061602_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176115
NZ_CP049838.1\|WP_171398967.1\|6058989_6059763_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223377
NZ_CP049838.1\|WP_171398971.1\|6067606_6068815_-\|nucleotide-sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|223749
NZ_CP049838.1\|WP_003948568.1\|6062393_6063005_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP049838.1\|WP_171398976.1\|6077609_6079310_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP049838.1\|WP_171398979.1\|6082970_6084851_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP049838.1\|WP_020132149.1\|6065823_6066948_+\|GuaB3-family-IMP-dehydrogenase-related-protein	unknown	unknown	gnl\|CDD\|236322
NZ_CP049838.1\|WP_028807228.1\|6063448_6064036_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|236607
NZ_CP049838.1\|WP_171398980.1\|6084973_6086617_+\|succinate-semialdehyde-dehydrogenase-(NADP(+))	unknown	unknown	gnl\|CDD\|236501
NZ_CP049838.1\|WP_171398968.1\|6059881_6060586_-\|MOSC-domain-containing-protein	unknown	unknown	gnl\|CDD\|225167
NZ_CP049838.1\|WP_171398973.1\|6071023_6072067_-\|beta-lactamase-family-protein	unknown	unknown	gnl\|CDD\|365903
NZ_CP049838.1\|WP_020132152.1\|6061684_6062014_-\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NZ_CP049838.1\|WP_171398975.1\|6074689_6077440_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916

Protein	Function_ID	Function_description	E-value
NZ_CP049838.1\|WP_171398966.1\|6058192_6058900_-\|ester-cyclase	gnl\|CDD\|377824	pfam07366, SnoaL, SnoaL-like polyketide cyclase. This family includes SnoaL a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486. The proteins in this family adopt a distorted alpha-beta barrel fold. Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalyzing intramolecular aldol condensation.	1.08146e-38
NZ_CP049838.1\|WP_171398978.1\|6081127_6082735_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	6.55668e-104
NZ_CP049838.1\|WP_171398972.1\|6069170_6070877_+\|glycerol-3-phosphate-dehydrogenase/oxidase	gnl\|CDD\|223651	COG0578, GlpA, Glycerol-3-phosphate dehydrogenase [Energy production and conversion].	1.05282e-163
NZ_CP049838.1\|WP_171398977.1\|6079382_6081035_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.5075e-105
NZ_CP049838.1\|WP_171398974.1\|6072319_6074542_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.6121e-99
NZ_CP049838.1\|WP_171398970.1\|6064190_6065696_+\|IMP-dehydrogenase	gnl\|CDD\|376340	pfam00478, IMPDH, IMP dehydrogenase / GMP reductase domain. This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains pfam00571 are inserted in the TIM barrel. This family is a member of the common phosphate binding site TIM barrel family.	0
NZ_CP049838.1\|WP_171398965.1\|6056461_6058087_+\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NZ_CP049838.1\|WP_171398969.1\|6060666_6061602_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176115	cd08423, PBP2_LTTR_like_6, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.18865e-54
NZ_CP049838.1\|WP_171398967.1\|6058989_6059763_-\|SDR-family-oxidoreductase	gnl\|CDD\|223377	COG0300, DltE, Short-chain dehydrogenases of various substrate specificities [General function prediction only].	1.2148e-80
NZ_CP049838.1\|WP_171398971.1\|6067606_6068815_-\|nucleotide-sugar-dehydrogenase	gnl\|CDD\|223749	COG0677, WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane].	5.17118e-128
NZ_CP049838.1\|WP_003948568.1\|6062393_6063005_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.73082e-50
NZ_CP049838.1\|WP_171398976.1\|6077609_6079310_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.14733e-103
NZ_CP049838.1\|WP_171398979.1\|6082970_6084851_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.76541e-93
NZ_CP049838.1\|WP_020132149.1\|6065823_6066948_+\|GuaB3-family-IMP-dehydrogenase-related-protein	gnl\|CDD\|236322	PRK08649, PRK08649, GuaB3 family IMP dehydrogenase-related protein.	0
NZ_CP049838.1\|WP_028807228.1\|6063448_6064036_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|236607	PRK09648, PRK09648, RNA polymerase sigma factor ShbA.	1.002e-89
NZ_CP049838.1\|WP_171398980.1\|6084973_6086617_+\|succinate-semialdehyde-dehydrogenase-(NADP(+))	gnl\|CDD\|236501	PRK09407, gabD2, succinic semialdehyde dehydrogenase; Reviewed.	0
NZ_CP049838.1\|WP_171398968.1\|6059881_6060586_-\|MOSC-domain-containing-protein	gnl\|CDD\|225167	COG2258, COG2258, Uncharacterized protein conserved in bacteria [Function unknown].	7.56574e-58
NZ_CP049838.1\|WP_171398973.1\|6071023_6072067_-\|beta-lactamase-family-protein	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	3.23505e-39
NZ_CP049838.1\|WP_020132152.1\|6061684_6062014_-\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	1.28755e-27
NZ_CP049838.1\|WP_171398975.1\|6074689_6077440_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.6727e-18

>NZ_CP049838.1|WP_020132149.1|6065823_6066948_+|GuaB3-family-IMP-dehydrogenase-related-protein
MTEIEIGRGKRGRRAYAFDDIAVVPSRRTRDPKEVSIAWQIDAYRFELPFLAAPMDSVVSPATAIRIGELGGLGVLNLEGLWTRHEDPQPLLDEIVELDAETATRRLQEIYAAPIKEELIGQRIKEVRDSGVVTAAALSPQRTAQFSKAVVDAGVDIFVIRGTTVSAEHVSGSHEPLNLKQFIYELDVPVIVGGCATYTAALHLMRTGAAGVLVGFGGGAAHTTRNVLGIQVPMATAVADVAAARRDYMDESGGRYVHVIADGGVGWSGDLAKAIACGADSVMMGSPLARATDAPGRGHHWGMEAVNEELPRGQKVDLGTVGTIEEVLTGPSHTPDGSMNLFGALRRAMATTGYSELKEFQRVEVTVADSVHRR
>NZ_CP049838.1|WP_171398970.1|6064190_6065696_+|IMP-dehydrogenase
MTANVDGVPGKFATLGLTYDDVLLLPGASDMAPDEIDTASYVSKNVRVNIPLLSAAMDKVTESRMAIAMARQGGVGVLHRNLSIEDQANQVDLVKRSESGMVTDPITIHPEATLAEADALCGKFRISGVPVTDGNKRLLGIVTNRDIAFETDRTRRVHEVMTPMPLVTGKVGISGVEAMELLRKHKIEKLPLVDDEGVLKGLITVKDFVKAEKYPHAAKDSEGRLLVGAAVGVAGDSFERAQALIERGVDFIVVDTAHGHSRLVGDMIAKIKSNHTRVDVIGGNIATRDGAKSLVDAGADAIKVGVGPGSICTTRVVAGIGVPQVTAIYEAALAAKEAGVPVIGDGGLQYSGDIAKALVAGADTVMLGSLLAGCEESPGELLFINGKQFKSYRGMGSLGAMQTRGERKSFSKDRYFQEGVASDEQLIPEGIEGQVPYRGPLSSVVHQLVGGLRQSMFYVGGRTVPELQDNGRFVRITSAGLKESHPHDIQMTVEAPNYSRK
>NZ_CP049838.1|WP_028807228.1|6063448_6064036_+|sigma-70-family-RNA-polymerase-sigma-factor
MRDDEAVTAVGTIGSLVHRAVDGDEQATHDLLAHVHPLALRYCRTRLSRLPGDARHFVEDLAQEVCVAVLLALPRYRDTGRPFEAFVFAIAAHKVADLQRAAMRHPGSTAVPSDEMPERPDDSLGPEERALLSSDAEWAKKLMANLPENQRELLLLRIAVGLTAEETGQMLGMSPGAVRVAQHRALSRLRALAEQ
>NZ_CP049838.1|WP_003948568.1|6062393_6063005_+|response-regulator-transcription-factor
MTSVLVCDDSPLAREALRRAVATVPGVERVTTAANGEEVLRRWGADRSDLILMDVRMPGLGGVETVRRLLSADPGARIIMLTVAEDLDGVALAVAAGARGYLHKDASRAELRATVTQALADPTWRLAPRRLRSAEMGAAPTLTAREIQVLEGMSHGRSNAEIGRELFLSEDTVKTHARRLFKKLGASDRAHAVALGFRWGLVR
>NZ_CP049838.1|WP_020132152.1|6061684_6062014_-|WhiB-family-transcriptional-regulator
MADFSRLPGPNADLWDWQLLAACRGVDSSLFFHPEGERGAARSARENSAKEVCMRCPVRAQCAAHALAVREPYGVWGGLTEDEREELMGRARNRLVSASSGARDASSNT
>NZ_CP049838.1|WP_171398969.1|6060666_6061602_+|LysR-family-transcriptional-regulator
MIEARHLRVLRAVAATGSFSAAGRELGCTQPAVSQQMKALEASVGTPLLIRSGREMRLTQAGEALVRHAAGILSGLTAAEEEVAAIAGLRAGRVRLVSFPSGSSTLVPTALAALRAAHPGTRVSLEEAEPPKSVELLREGDCDIALAFRYERATGTGGAEQAGEGEWDDLVVRPLLTDRLVALVPERHRLARTGPSGSVAIGDLAAEPWIAGCPRCRGQLIQVCESAGFTPRIDFATDDYPAVVGLVGAGLGVAVLPQLAIESVRPRGARAVTLEPAVRREIVALTLPDLAQVPAVSATLEQLGRAAARVG
>NZ_CP049838.1|WP_171398968.1|6059881_6060586_-|MOSC-domain-containing-protein
MRLLSVNLGRPKAVPYTDQPQGLTGIDKRPVEGPVRVAAPGPKGVGASGLAGDTVCHLRHHGGDDQAVYAVAREDLDDWERELGRTLANGAFGENLTTTGLDVSGARIGERWQIGPDLVLEVTAGRIPCRTFQGHVGEKRWVRRFTEKAATGAYLRVVVPGEIRAGDPVRIVHLPEHEVTARMQFQAATTHRELLPRLLAAGEALHSESLAAAREYVAKYGDGSGAKHTETSGG
>NZ_CP049838.1|WP_171398967.1|6058989_6059763_-|SDR-family-oxidoreductase
MTTALITGSTAGIGAAFARRLAADGHDLVLVARDIKRLREQATELHDRHGIEAEVLTADLATDKGIEAVAARLGDRKNPVDLLINNAGFGNKGRYLDVSMADELKMLKVHCEAVLRLTSAATAAMRERGRGGVVNVASVAAFVPRGTYGASKAWVVQFTQGAAKDLAGSGVRLMALCPGFVRTEFHERAGMGTDNIPGWMWLDADKLVAAALHDLARGKSLSIPDPRYKALMGLVKVTPRSLLGGISSRTGRKYGPQ
>NZ_CP049838.1|WP_171398966.1|6058192_6058900_-|ester-cyclase
MTFVQLIDCKTSRFDEMDRLMDTWVEQTRGKRTASHAVVGKDRSDASHFIEIVEFPSYEEAMRNSNLPETDKVFRELVALCDEMPTFTDLDVVRDEQLYAGTARRFFETIGTRGELPPLDGLLAEDYHDHDPANEQDTMGMDAMRREVEMWRGGFDFAFSLDDQIEQGDRVCNRWSWSGTHKGDFMGIPATGKRVTMTGTTVFRCREDGKIAEAWWQYDRLGLMEQLGALDGLER
>NZ_CP049838.1|WP_171398965.1|6056461_6058087_+|chaperonin-GroEL
MAKILKFDEDARRALERGVNKLADTVKVTIGPKGRNVVIDKKFGAPTITNDGVTIAREVELDDPYENLGAQLVKEVATKTNDIAGDGTTTATVLAQALVREGLKNVAAGASPAALKKGIDAAVKAVSEELLATARPIDDKADIAAVAALSAQDQQVGELIAEAMDKVGKDGVITVEESNTFGLELDFTEGMAFDKGYLSPYFVTDQERMEAVLEDPYILINQGKISSIADLLPLLEKVIQTNSSRPLLIIAEDLEGEALSTLVVNKIRGTFNAVAVKAPGFGDRRKAMLQDLAVLTGATVISEEVGLKLDQVGIDVLGSARRVTVTKDDTTVVDGAGDSAEVQGRVGQIKAEIENTDSDWDREKLQERLAKLAGGVCVIKVGAATEVELKEKKHRLEDAISATRAAVEEGIVSGGGSALVHAAKVLEGGLGKTGDEATGVAVVRRAVVEPLRWIAENAGLEGYVITSKVAELDKGQGFNAATGEYGDLVKAGVIDPVKVTRSALENAASIASLLLTTETLVVEKKEEEEPAAAGHGHGHSH
>NZ_CP049838.1|WP_171398971.1|6067606_6068815_-|nucleotide-sugar-dehydrogenase
MPADLAVIGLGPFGLPLAQAAVAAGIPTIGYRTGPEAGSLSPAELRRMLSGGFRAATNPAELGRVRTAVICAPTPRDADGGLDLSQLETAARTLAGHLRPHTTVILESPVYPGATEEFLRPLLEETSGLRAGRDFHLAYSPSRVDPGSRAFNPANTPKVIGGLTPACTESAAAFYGRLTDKVVRARGLREAETVQLLETNFRHVNIALVNEMAVLCHDLGVDLWDVVRCAETKPFGFEAFRPGPGVGGHSVPLDRTGHPGSPLRLVELAQQVNSRMPRYVVQRAAALLNEHGKSARGARVLLLGVTYKPDLADQQNTPAREIAIRLMELGAAVSYNDPHVPSWSVLDRPVPRADSLYEAAADADLTILLQQHRTYDLQGLSVKAQLLLDTRGATPTGAAHRL
>NZ_CP049838.1|WP_171398972.1|6069170_6070877_+|glycerol-3-phosphate-dehydrogenase/oxidase
MRTATLGPAQRAESLAAMAERELDVLVVGAGVVGAGTALDAVTRGLSTGLVEARDWASGTSSRSSKLIHGGLRYLEMLDFALVREALKERGLLLERLAPHLVKPVPFLYPLQHKGWERLYAGSGVALYDAMSMARGHGRGLPTHRHLTRGHALRVAPALKKDALVGALQYYDAQMDDARFVATLVRTAVAYGAKAANRARVTGFLREGERVVGARVQDAEGGGEYEIRARQVVNATGVWTDDTQAMVGERGQFHVRASKGIHLVVPRDRISSSSGLILRTEKSVLFVIPWGRHWIIGTTDTDWDLDKAHPAASSADIDYLLEHVNSVLRVPLSRDDVEGVYAGLRPLLAGESDATSKLSREHTVAHPVPGLVVVAGGKYTTYRVMAKDAVDEAVRGLDQRVADCVTEDVPLMGAEGYRALWNARARIAARTGLHVVRVEHLLNRFGAMAEEVLDLIATDPTLGEPLQAADDYLRAEIVYAASHEGARHLDDVLTRRTRISIETFDRGTRSAREAAELMAPVLGWDKDQIEREVQHYEKRVEAERESQRQPDDLTADAARLGAPDIVPL
>NZ_CP049838.1|WP_171398973.1|6071023_6072067_-|beta-lactamase-family-protein
MRPLRSMVAIPVALALLGLFATGSQAAPVPPTDSLLPLLLTRGKAPAAALLAREESGTRYAEAGPGISRSDHFRAGSVTKTFLATVVLQLAAEHRLSLSDTVESHLPGLVRGAGNDGRALTLRSLLTHTSGLYDFTRDTEGTVPVLPLQAVRIAVTHPPADRGRFAYSNTNYVLLGLVVEQVTGRSYATEAERRIISPLRLTGTSFPGSRTSLPSPHGRAYDPDGTDVTELDPRVAGAAGELVTTLTDLDRFYAALLGGELLPPRRLREMLDTRTAHGSYGMGLFPAKLPCGVTVWGHNGRISGSYVRTAATVDGRRVLTFRVNTTAIADPALEPALLAAEFCPRNP
>NZ_CP049838.1|WP_171398974.1|6072319_6074542_+|serine/threonine-protein-kinase
MSEAERAGASRQDKSARLLAGRYRLGDVLGRGGMGTVWRAEDETLGRTVAVKELRFPGNIDEDEKRRLITRTLREAKAIARIRNNSAVTVFDVVEEDDRPWIVMELVEGKSLAEVIREDGVLEPKRAAEVGLAILDVLRSAHREGILHRDVKPSNVLIAEDGRVVLTDFGIAQVEGDPSITSTGMLVGAPSYISPERARGHKPGPAADLWSLGGLLYAAVEGSPPYDKGSAIATLTAVMTEQLEEPKNAGPLRDVIYGLLTKDPARRLDDAGARAMFNAVLHAPEPRHAEPADATKVVPLPALPDAAGGRGGSAGAEAGEKLRGAFRSVRKAAVAAGAATSAAAARAKSANGTSASGSVGAPEAQKSEAYKGEARKGGAARGTGAAASAAAPSAAPPAAPASRATTGSASTSAPGPTSRPTSRPVSGAARPSASVPAARSGSGSGSGTGAGVGAGAGAGAGSGGNGGGAGRSSGWPVMTPPDLPPRSVPRAPLTDVVPKRTLVIIAVVVALAVLGTVLALTLGGGDDTAGGAKGGAGSGAVAGGSASASADTKEDEDSGTRTDGSSSSQPAASSASASGDTSAAGGAGSGVTASGDSKAVTTHKGGQGYSIGLPTGWKYQSAGSAGDRFTGPDGQKLLVAWTTTPKDDPVADWNNQERGMKRSQYKKIRIEKADYRGWNTADWEFTYTDGGTAYRTIDRGFVVNDSLGYALMYTAKSAAWGTDLRQTTWTTLTDTFTPKK
>NZ_CP049838.1|WP_171398975.1|6074689_6077440_+|protein-kinase
MTDRAAGGGNVDDYAGRVLVDRYRLPLPPSDEYELTETRAFDTYSGQEVLVRQVPLPEVVEAEVLDAEGLPEGFTARERGARRPRPRGVGVGEGTRRPADPVVRRALEAAQATASIPDHPRLDQVFDVFAEGGSLWIVSELVAARPLAALLAEKPLTPYRAAEVASDVLMALRVLHGHGWVHRNITARTVLVCDDGRVMLTGLAVGAAEEALCGYDPVPAPDAAEREQGAAGRENGGAGHGGSVVGPRASASPPRQDGPGALAGPAGPAGPGGSGGFAGSGGSVEAGSGSSGGGLGAGAVDPEAARRAAIEARASGALPVPAGEPSGGGGASGAVARRAPIETGGDIRAARAGAIAAYRAGARAAARVQEAQEAQQNGRAALPGARTPADDGHGIPGGNPPGQIADPYGVSGAPVPGPAGYGQGQPAHVHTAGSGPGGAPYAAPPASHPPLMPVPGTQVPVQGQGQGPSGEVRGGARWDELVAGAPGSVARRGPATALAAERARQARMAVVGPVTERWAPEQAGPVHENWQLAAPIGPATDLWALGALLFRAVQGHAPYPEESTAELVQMVCAEPPAFAEECGPLRPVVESLLRQDPTERLGYEELRGWLRSLVRSAPEPEAGTYVVAAPPTDPRRLPIVRRRGELVRRRRAGLPATHGRHKRGRPETSGSPRSLGRTLLVLILLLLAGAIAYALLFMPKADEEGAAGTDGSQRTGATGTPGGQAPEASSEPRPDQTSPGTGASPSSASSGAEATQTQTGGAGTDVADGFTVRADDAGFRVAVANGWDRTPKNGRGQVVYAHGDFELIVVPGRDSASSNGSDPMVYQREKESELQPYRDSSWATASGLRTTTVGTRTMAEGQFTWTDGDGRALYVRNVAILISGRYHIVQVRGPEAERDEVTRLFEQASATYQYTG
>NZ_CP049838.1|WP_171398976.1|6077609_6079310_+|protein-kinase
MQGLLLAGRYRLADAIGSGGMGRVWRAHDELLHRAVAIKELTAALYVAEGDQAVLLARTRAEARAAARINHSAVVTVHDVLEHDGRPWIVMELVEGRSLADAVKEDGRVEPTEAARIGLWVLRALRAAHSAGVLHRDVKPGNVLLSHDGRVLLTDFGIAQIEGDSTITRTGEVVGSVDYLAPERVRGQDPGPSSDLWALGATLYTAVEGRSPFRRTSPLTTLQAVVEEEAADPGYAGPLGPVITALLRKDPATRPDTAETEQLLAEAAEGRRPDGAQAYVPTQYGGPDRASGDRHPAGHPLSHPTAGTAYVPVAPEAATPVPGHPVTAATAVGPTHIGGGPDTRPSRQSQPPRRRRRVLALVVVLAALVGGGTAVAWQKWDEGRQDTGGSASTSPSPSTPAGTSTPGEQGADSWQEINDPLGFGLSLPKGWEREVYQDDGDLKQIDYTPDGGEHFIRIALDKSPDFSDPYAHQVDLEQQLKRLVAYNRVTLERNVYRDRDGSEWEYTWTALAKDTDFPGPRRAIEETYVARDGSEYVIYMSSPAEDWTEAAKQFKSVLQSWREPTS
>NZ_CP049838.1|WP_171398977.1|6079382_6081035_+|serine/threonine-protein-kinase
MGTEGTEGSGDGVRVIAGRYRLDARLGRGGMGVVWGATDQLLGRRVAVKELTRDDTLSDEEARGRRDRTLREARAVAQLSHPHIIVVHDVVEDGERPYIVMELIDGGSLADRIAARGPIEPAEAARIGIALLGALRAAHAAGVLHRDIKPANVLLEGDSDRVVLTDFGIAQVAGATTLTETGSFVGSPEYTAPERMSGTRTGAEADLWSLGALLCTALSGESPFRRDSLGGILHAVVFAEIRTPAQAEPLLPVVRGLLERDPDRRLGAAEAERLLRAYLDTGCTPTPVSSGYTPTQADLPRPRWEPPARERSTRGVLVAALLVAAMAGAGVSAAALLLNGDGDGGRTPTSSAPGFSASGSTSPTPTGTPSATRSPSGSSTSPTSSRPSPSASPASDDRPGTPTAPSGYRVAVDPAGFSLAVPEDFTRLPQGERVFYMSPGQVFRLGIKVAAAPPGGPLAVMESAAAKGPDTNPGYHDGRVTETGHGGRPAALWEFTWNGFTAAEGPRHTYDLCWEEGGLLYDVWVSAPVGKVREAREYFDVAVDTFAVST
>NZ_CP049838.1|WP_171398978.1|6081127_6082735_+|serine/threonine-protein-kinase
MSFDGGAGHEADETTSFVLQPPRPAPQQAAVPVQVAPPQEPGVGRLIAGRYRLLAKLGHGGMGTVWRAKDETVDREVAVKEPRVPDHLPERERANAFERMRREARAAARLDHPAVVNVHDVAVVDGRPWIVMELVHGRSLGDALQEGTLSAREAARVGLEVLGALEAAHAAGILHRDVKPDNILLGRHDRIVLTDFGIAQIEGETNLTDTGGIVGSPEYIAPERVLGQRPGPAADLWSLGVVLYAATEGVSPFRRSNTPATLQSVLNAVPAPPAAAQGPLAEAVNGLLEKDPARRPAAARVRALLEAAANPPAPQPTQVVRQVEVPRARRRFGRAVWTGLGAAVVAAAVTAYLVVADPFAGPLPDDWKTPHVKDVTAKVAVPDSYKQGLPDRESDDSHWVSYTDPSGAISVVLSVARKAEDTGKEIKASAAAEMYADDGDFKENGSYNLDMPKSPKTQPDDNTTFHEQKAAGNTVSYTTDDTQDPRPRELRILYYKSAAGDMYRLTIAYPGAGDFTARGREVARTAIANLDLDKL
>NZ_CP049838.1|WP_171398979.1|6082970_6084851_+|serine/threonine-protein-kinase
MSNDGGPGGAESRTVGGRYRLLERIGSGGMGTVWRARDELMEREVAVKQPRLPGDPEDDFHRRAAHRLHREARAAARVDHPSAVAIHDVVVEEGTGADAEGGLPWIVMELVRGESLHEVLKRGPLEPAEAARIGLAVLGALRAAHAVGIVHRDVKPANVLVGPHGRVVLTDFGIAHIQGEESLTVSGEFVGSLEFVAPERMSGRGGGPASDLWSLGVLLYAAVEGWSPFRRTTVESTLAAIIAADPPEPKQAGPLGPLVVRLLVRDPVQRPDPAEVAEILAAVTEGRPVPAPAGERGEDTEAVERGERGEHGEYRTGEAEKAERAEEAAKAPEEEKTEDEEKAEEAEPQDVRALQEFGEDAGTVRVGAARRDPAQPSAPPTATDRPGPQPDPASASASAPASAPAPATEPGSVGAGRVRRSLRRRSPVLAVLGGLLVGGTWWGSAWLGGADSGAGERPVTYAGSASTEPSASAVTGARWVAHREAGLDAVLSLPSRYRQSARQGGADQQPRLVVYSAGSVDVRLTLWDQAPAAPMARAAQAHETWNGYALDARTQTTRSSFHGDEAALADTTYGLDATPTRVMELFVLTADARMYELRVDMPKGTPEEKQGTAVFKEARDRLEIGK
>NZ_CP049838.1|WP_171398980.1|6084973_6086617_+|succinate-semialdehyde-dehydrogenase-(NADP(+))
MTDSQAPEKTGTEISGKTTTGTNPLAPAPTGVRTAEDVVTPELVAQLTKGVTGSGRTANHTPFTGGKLADLPESTPDDVLKAFEAARKAQAVWERTPVRERAAVLLRFHDLVLERQAEVLDLIQLETGKARLHAHEEVQAVAVAARHYGRKAPAYLRPKRHAGAMPTLTKVTELRHPRGVVGQIAPWNYPLELSVGDALPAFVAGNAVVMKPDTETCLTALWARDLLVEAGLPAEVFQVVLGEGPVVGPEVVRHADYVSFTGSTRTGREVAQGAAARLVGVSLELGGKNAMLVLEDADIEKAAAGAVRACFSSAGQLCISIERLYVHESIADAFVERFAARTKAMRLGTSLAYGADMGSLVGERQLETVTRHVEEAVAKGAKVVAGGVARPDIGPYFFEPTILDGVTEPMSVCTEETFGPVVSIYRFKTDDEAVEQANSTPYGLNSSVWTKDGRRGREVASRLRTGTVNVNEGYAPAYGSVQSPMGGMKDSGLGRRHGSEGILKYTEAQTVAQQRLLPMAPALGMNDEKYAEFMSRSLRLMKAFRFR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP049838_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049838_15

6250138-6250649

Orphan

Consensus_repeat	Method
NGNGNGCNGGGNGCGGGG	CRT

7 spacers

The CRISPR arrays of NZ_CP049838_15

>merge|NZ_CP049838|15|6250138-6250649|CRT
TGAGGGCGGGGTGCGGGGTGCCTAGTGCCGGTGGGGTGCGGGGTGCGGGGTGCCTAGTGCCGGTGGGGTGCTGGGCGCTGAGGGTCAGGTGCCGGGCGCTGAGTGCGGGGTGCCGAGGTGCGGGGCGCGGGGTGCTAGTGCCGGTGGGGTGCGGGGTGCGGGGTGCGGGGTGCTGGGCGCTGAGGGTCGGGTGCCGGGCGCTGAGTGCGGGGTGCCGAGGTGCGGGGTGCGGGGTGCAGGGTGCCGAGGATCGGGTGCCGGGCGCGGGGCGCCTACCGCGTGCCGGGCGCTAAGTGCCCGATGCGGGGTGCCGAGGTGCGGGGCGCGGGGTGCTAGTGCCGGTGGGGTGCGGGGTGCTGGGCGCTGAGGGTCGGGTGCCGGGCGCGGGGCCGCCTACCTAATGCCGGGCGCTGAGTGCCGGGTGCGGGGTGCCGAGGGCCGGGCGCGGGGTGCCTAGTGCGGGGTGCCGAGGGGCGGGCGTGGGGGTGAGGGCTCGGAGGCCCGGGGTGGGT

>NZ_CP049838|15|4|6250138-6250649|CRT
TGAGGGCGGGGTGCGGGG	TGCCTAGTGCCGGTGGGGTGCGGGGTGCGGGGTGCCTAGTGCCGGTGGGGTGCTGGGCGCTGAGGGTCAGGTGCCGGGCGC
TGAGTGCGGGGTGCCGAG	GTGCGGGGCGCGGGGTGCTAGTGCCGGTGGGGTGCGGGGTGCGGGGTGCGGGGTGCTGGGCGCTGAGGGT
CGGGTGCCGGGCGCTGAG	TGCGGGGTGCCGAGGTGCGGGGTGCGGGGTGCAGGGTGCCGAGGAT
CGGGTGCCGGGCGCGGGG	CGCCTACCGCGTGCCGGGCGCTAAGTGCCCGATGCGGGGTGCC
GAGGTGCGGGGCGCGGGG	TGCTAGTGCCGGTGGGGTGCGGGGTGCTGGGCGCTGAGGGT
CGGGTGCCGGGCGCGGGG	CCGCCTACCTAATGCCGGGCGCTGAGTGCCGGGTGCGGGGTGC
CGAGGGCCGGGCGCGGGG	TGCCTAGTGCGGGGTGCCGAGGGGCGGGCGTGGGGGTGAGGGCT
CGGAGGCCCGGGGTGGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049838.1\|WP_171399106.1\|6259964_6261737_-\|biotin/lipoyl-binding-protein	unknown	unknown	gnl\|CDD\|227111
NZ_CP049838.1\|WP_171399096.1\|6245976_6246891_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|365919
NZ_CP049838.1\|WP_171399105.1\|6256598_6258047_+\|NAD(P)H-quinone-dehydrogenase	unknown	unknown	gnl\|CDD\|236112
NZ_CP049838.1\|WP_171399092.1\|6240755_6242381_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP049838.1\|WP_078889947.1\|6258235_6259201_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP049838.1\|WP_171399093.1\|6243697_6244441_+\|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028
NZ_CP049838.1\|WP_171399100.1\|6250844_6252539_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171399107.1\|6262110_6262605_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171399091.1\|6239393_6239945_-\|VanZ-family-protein	unknown	unknown	gnl\|CDD\|377417
NZ_CP049838.1\|WP_028807033.1\|6242377_6243055_-\|two-component-system-response-regulator-AfsQ1	unknown	unknown	gnl\|CDD\|223816
NZ_CP049838.1\|WP_171399102.1\|6254806_6255631_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|236183
NZ_CP049838.1\|WP_171399097.1\|6246880_6248332_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143429
NZ_CP049838.1\|WP_171399104.1\|6256063_6256501_-\|gamma-glutamylcyclotransferase	unknown	unknown	gnl\|CDD\|372719
NZ_CP049838.1\|WP_171399098.1\|6248337_6249300_-\|deoxyribose-phosphate-aldolase	unknown	unknown	gnl\|CDD\|188646
NZ_CP049838.1\|WP_171402213.1\|6240132_6240750_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171399095.1\|6245463_6245892_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171399103.1\|6255729_6256011_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171399094.1\|6244699_6245407_-\|uridine-kinase	unknown	unknown	gnl\|CDD\|223645
NZ_CP049838.1\|WP_171399108.1\|6262573_6263179_-\|septum-formation-inhibitor-Maf	unknown	unknown	gnl\|CDD\|178901
NZ_CP049838.1\|WP_171399101.1\|6253120_6254752_-\|phospho-sugar-mutase	unknown	unknown	gnl\|CDD\|100092

Protein	Function_ID	Function_description	E-value
NZ_CP049838.1\|WP_171399106.1\|6259964_6261737_-\|biotin/lipoyl-binding-protein	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NZ_CP049838.1\|WP_171399096.1\|6245976_6246891_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|365919	pfam00171, Aldedh, Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.	9.86909e-41
NZ_CP049838.1\|WP_171399092.1\|6240755_6242381_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	6.86586e-54
NZ_CP049838.1\|WP_078889947.1\|6258235_6259201_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	2.38209e-81
NZ_CP049838.1\|WP_171399093.1\|6243697_6244441_+\|SigE-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	5.00888e-63
NZ_CP049838.1\|WP_171399091.1\|6239393_6239945_-\|VanZ-family-protein	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	1.50836e-21
NZ_CP049838.1\|WP_028807033.1\|6242377_6243055_-\|two-component-system-response-regulator-AfsQ1	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.45006e-81
NZ_CP049838.1\|WP_171399102.1\|6254806_6255631_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|236183	PRK08202, PRK08202, purine nucleoside phosphorylase; Provisional.	1.13764e-133
NZ_CP049838.1\|WP_171399097.1\|6246880_6248332_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143429	cd07111, ALDH_F16, Aldehyde dehydrogenase family 16A1-like. Uncharacterized aldehyde dehydrogenase family 16 member A1 (ALDH16A1) and other related sequences are present in this CD. The active site cysteine and glutamate residues are not conserved in the human ALDH16A1 protein sequence.	0
NZ_CP049838.1\|WP_171399104.1\|6256063_6256501_-\|gamma-glutamylcyclotransferase	gnl\|CDD\|372719	pfam13772, AIG2_2, AIG2-like family. This family is found in bacteria and metazoa.	8.40379e-24
NZ_CP049838.1\|WP_171399098.1\|6248337_6249300_-\|deoxyribose-phosphate-aldolase	gnl\|CDD\|188646	cd00959, DeoC, 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family. 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family. DERA belongs to the class I aldolases and catalyzes a reversible aldol reaction between acetaldehyde and glyceraldehyde 3-phosphate to generate 2-deoxyribose 5-phosphate. DERA is unique in catalyzing the aldol reaction between two aldehydes, and its broad substrate specificity confers considerable utility as a biocatalyst, offering an environmentally benign alternative to chiral transition metal catalysis of the asymmetric aldol reaction.	9.65187e-77
NZ_CP049838.1\|WP_171399105.1\|6256598_6258047_+\|NAD(P)H-quinone-dehydrogenase	gnl\|CDD\|236112	PRK07845, PRK07845, flavoprotein disulfide reductase; Reviewed.	0
NZ_CP049838.1\|WP_171399094.1\|6244699_6245407_-\|uridine-kinase	gnl\|CDD\|223645	COG0572, Udk, Uridine kinase [Nucleotide transport and metabolism].	2.63374e-11
NZ_CP049838.1\|WP_171399108.1\|6262573_6263179_-\|septum-formation-inhibitor-Maf	gnl\|CDD\|178901	PRK00148, PRK00148, Maf-like protein; Reviewed.	2.02992e-94
NZ_CP049838.1\|WP_171399101.1\|6253120_6254752_-\|phospho-sugar-mutase	gnl\|CDD\|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0

>NZ_CP049838.1|WP_171399098.1|6248337_6249300_-|deoxyribose-phosphate-aldolase
MPTNTPTAADALTDVTASDSSLRRFLHGLPGVDTVGLEARAAALGTRSIKTTAKAYAIDLAISMVDLTTLEGADTPGKVRALGAKAVHPDPTDRTTPTTAAVCVYPDMVATAKAAVAGSGVKVASVATAFPAGRAALEVKLADVRDAIAAGADEIDMVIDRGAFLAGKYLKVYDEITAVREACGTSARLKVIFETGELSTYDNIRRASWLGMLAGADFIKTSTGKVAVNATPPNTLLMLEAVRDFRAQTGVQVGVKPAGGIRTTKDAIKFLVLVNETAGEDWLDNHWFRFGASSLLNDLLMQRQKLATGRYSGPDYVTVD
>NZ_CP049838.1|WP_171399097.1|6246880_6248332_-|aldehyde-dehydrogenase-family-protein
MASTTASAFEYAPAPESRSVVDIAPSYGLFIDGEFTEAAEGKVFKTVSPSTEEVLSEIAQAGEADVDRAVRAARKAFGKWSALPGSERAKYLFRIARIIQERSRELAVLETLDNGKPIKETRDADLPLVAAHFFYYAGWADKLDHAGFGASPRPLGVAGQVIPWNFPLLMLAWKIAPALATGNTVVLKPAETTPLSALFFADICRQAGLPKGVVNILPGYGDAGAALVAHPDVNKVAFTGSTAVGKAIARQVAGSHKKVTLELGGKGANIVFDDAPIDQAVEGIVSGIFFNQGQVCCAGSRLLVQESIQDELLESLKRRLATLRLGDPLDKNTDIGAINSAEQLSRITSLVEQGEAEGAERWSPACELPTSGYWFAPTLFTNVTQAHTVARDEIFGPVLSVLSFRTPEEAVAKANNTPYGLSAGIWTEKGSRILAVASKLRAGVIWSNTFNKFDPTSPFGGYKESGFGREGGRHGLEAYLDVR
>NZ_CP049838.1|WP_171399096.1|6245976_6246891_-|aldehyde-dehydrogenase-family-protein
MSDKTDKTEQQQRLSVFKTYKLYVGGKFPRSESGRVYEVTDAKGKWLANAPQSSRKDARDAVVAARKAFGGWSGATAYNRGQILYRVAEMLEGRKGQFVTEVAEAEGLSKSKAADQVEATIDRWVWYAGWTDKIAQVVGGGNPVAGPYFNLSSPEPTGVVAVLAPQESSFLGLVSVLAPVIATGNTAIVIASERSPLPALSLGEVLATSDVPGGVVNVLSGRTAEIAAPLAAHQDVNAIDLAGADDVLAKELEIAAADNLKRVLRPQPVDDWSAAPGTDRMTAFLETKTVWHPTGSLGASGSSY
>NZ_CP049838.1|WP_171399095.1|6245463_6245892_+|hypothetical-protein
MARHASPQTSTGRRALAALATAGVALGAGAGTAAAATGEPAVDVVRTRPTSVGQLDPQAGVQGVLGSLTYVTGSVAGLKPNPLAGTGVDPLDNGVGTQLADFKPLTSQMLTGPVAQAQSIGSVPVLGDVTKALGGVTKVLGG
>NZ_CP049838.1|WP_171399094.1|6244699_6245407_-|uridine-kinase
MTRASKPTRGVVDGRGDASHWCPVTSPPPIPTRVVLLCGPSGSGKSLLAARSGLPVLRLDDFYKEGDDPTLPLVAGSSDIDWDDPGSWDADTAVASIVELCGTGRTNVPVYDISLSARTGADAIEIGRTPLFIAEGIFAAEIVNRCRELGVLADALCLSRGPVKTFRRRFLRDLKEGRKSVPFLLRRGWRLMRAERSIVARQTALGAHACDRDEAMGRLASAAAGRRAPTARTAA
>NZ_CP049838.1|WP_171399093.1|6243697_6244441_+|SigE-family-RNA-polymerase-sigma-factor
MNTLHGMSANAVAVVTRLHDVHRGSEKSGAVSGRGCARGTGRQHTTFMTVVDTGEQAAHGGATYREDTGERRSLTEAEFTAYVQERRASLYATAYHLTGDRFEAEDLLQSALFSTYRAWDRISDKAAVGGYLRRTMTNLHISAWRRRKLNEYPTEELPETAGDTDAMRGTELRAVLWQALARLPELQRTMLVLRYYEGRTDPEIAEILDISVGTVKSSIWRSLRRLREDEVLSFGRDEEDAFGELVA
>NZ_CP049838.1|WP_028807033.1|6242377_6243055_-|two-component-system-response-regulator-AfsQ1
MPSLLLIEDDDAIRTALELSLTRQGHRVATAASGEDGLKLLREQRPDLIVLDVMLPGIDGFEVCRRIRRTDQLPIILLTARSDDIDVVVGLESGADDYVVKPVQGRVLDARIRAVLRRGERESSDSATFGSLVIDRAAMTVTKNGEDLQLTPTELRLLLELSRRPGQALSRQQLLRLVWEHDYLGDSRLVDACVQRLRAKVEDVPSSPVLIRTVRGVGYRLDAPQ
>NZ_CP049838.1|WP_171399092.1|6240755_6242381_-|HAMP-domain-containing-histidine-kinase
MTQRQGGLRGWSAARKGRLSRLRFTSLRLRLVVVFGAVALTAAVSASGIAYWLNREAVLTRTQGAVLRDFEQEMENRAGSLPEHPSQDELQHTAGQMANSSQRFSVLLVGEDSSGKTVYGNSGGLNGFSLEDVPGALRTAVNKRQDVTGGNKSPYHLYWQRVVDHGTPYLVAGTQVNGGGPTGYMRKSLEPEAKDLNSLAWSLGIATGLALIGAALLAQAAGTTVLKPVHRLGVAARRLGEGRFDTRLRVSGTDELADLSRTFNRAAESLEKRVADMAARDNASRRFVADMSHELRTPLTAITTVAEVLEEELDAESGSIDPMIEPAVRLVVSETRRLNNLVENLMEVTRFDAGTARLVLDDVDVADQITHCIDARAWLDAVDLDAERGIHALLDPRRLDVILANLIGNALKHGGSPVRVSVSAADDAVVISVRDHGPGIPEEVLPHVFDRFYKASASRPRSEGSGLGLSIALENAHIHGGEITAANSPEGGAVFTLRLPRGVLEAADQGGEEDERAVRPAHSVQSMPVQSGKSVQDKGDA
>NZ_CP049838.1|WP_171402213.1|6240132_6240750_-|hypothetical-protein
MRRATVRRLLAVPVLAGLLAGCGIRATEVPTDFGPAPSRARCSLTEPDVTSQSARAGVPVQVFLLCGSSLVTVDRSVRVPNGAADFERRVLVAQGLLDQLAESPSAAEKEAGYTTDVRGGMTVGGPGAKDPDDALRLSTPPGNLTSYALAQLVCTFSDSAAAEGDGSVILGGPGSDPLRRYGCTDEVRSRPGSAEPPSSAVTDSG
>NZ_CP049838.1|WP_171399091.1|6239393_6239945_-|VanZ-family-protein
MQRQGSIGGSAAIRIRATGILLLAAHLVFVAWVALRPLNVPWVVPANLHPFDGIRADLRLGWPEAARRIGEGLGLLAPLGFLLPLVHGRLRVSPLASLIRTVTAGALLSLGIELLQTGVPGQVVDVDSMLLNTLGVALAHVAVVPAVRGWLRRRDERRGRAAVRQEEAAQGLTPRITRVGVAP
>NZ_CP049838.1|WP_171399100.1|6250844_6252539_+|hypothetical-protein
MSTHSAEVLRLPEAAVPEGCRSWDAEQAGRWTRGLPPRWVPVRARTSVFVALPVVALAGAGLLHLSAGLPAWAAALVALNVVWLVLRPEAALVLVPFAAAVVLTPGDFAWPVRLGLLTALVGVWAAVGLRLAARKRQRAAGLDAAGGVTAEVPRAPGAAGGRAERGTFLLWSGLVTVVAGGSLYATAGLWDLAEDRQAVPAAGWCLAGLGLTVLLSSALARRRAVGLRWAPVPVLRVLVRENGDVETEVFAADDLAALRPLFTVSTVELAGRAEGDDDDDDDDENEDNADDESLRELISRIDDERAGPLREAVLYGAPYDGAEVVFLAAADKAGEPPVVEASVGPVRPVTGVAFRWRARTEKGKALREARQEALRGAAAAVVAERIGQEAAAVGVRRWRAGWADWFAVGLVLLFVSLYWEDSGWWRYGYALVATLLAALLLPRRIAWRVTADREGLWFNGLGGTRHLAWDHVRAVECEGVRLRIHGRQASFEEWRVASPRWPWLESRFGLVHPYERTAAEITAMWRDPAARPADLADERQRGRALWPLGLVIGIVGTATVALLP
>NZ_CP049838.1|WP_171399101.1|6253120_6254752_-|phospho-sugar-mutase
MHDDLIARAQTWLAEDPDPETRAELAELLDAGDVTELAERFGGTLQFGTAGLRGELGAGPMRMNRSVVIRAAAGLAAYLTENGGTGGVVVIGYDARHKSEDFARDTAAVMTGAGFRAAVLPRPLPTPVLAFAIRHLGAVAGVEVTASHNPPRDNGYKVYLGDGSQIVPPADAEIAAEIDAIAALKDVPRPEAGWQTLDDAVLDAYLARTDAVLAADSPRTARTVYTAMHGVGKDVLLAAFARAGFPEPVLVAEQADPDPDFPTVAFPNPEEPGAMDLAFARARETGPDLIIANDPDADRCAVAVPHEGDWRMLRGDEVGSLLAAHLVRRGARGTFAESIVSSSLLGRIAEKAGLPYEETLTGFKWIARVDGLRYGYEEALGYCVDPEGVRDKDGITAALLITELASTLKSEGRTLLDLLDDLAVEHGLHATDQLSVRVQDLSLIARAMERLREQPPTSLAGLAITRAEDLTLGTDKLPPTDGLRYTLDGARVIVRPSGTEPKLKCYLEVVVPVPAHADLPTAHSTANALLTAIKHDLSAAAGI
>NZ_CP049838.1|WP_171399102.1|6254806_6255631_-|purine-nucleoside-phosphorylase
MNASLLPDDIQGDPHAAADAAAARLRELTGAETHDVALVMGSGWAPAVDALGAPDAEFQVTELPGFPPPAVEGHGGKIRSYQIGAKRALVFLGRTHYYEGRGVAAVAHGVRTAVAAGCKTIVLTNGCGGLREGMRPGQPVLISDHINLTATSPIVGANFVDLTDLYSPRLRTLCKEIDATLEEGVYAQFPGPHYETPAEIRMARTIGADLVGMSTVLEAIAAREAGAEVLGISLVTNLAAGMTGEPLNHEEVLQAGRDSATRMGSLLAQVLGRL
>NZ_CP049838.1|WP_171399103.1|6255729_6256011_-|hypothetical-protein
MTGRTAYTVFYTEQAAAARDRLDEQQRAAFEKGIMMLAADPFPDLSRPISSTGDDRTIRLTQNILIEYTVSIGRLLIFIVEVFNDKDIFVTGE
>NZ_CP049838.1|WP_171399104.1|6256063_6256501_-|gamma-glutamylcyclotransferase
MSLYAAYAGNLDARLMTRRAPHSPLRATGWLNGWRLTFGGEQLGWEGALATVAEDPGAQVFVALYDVAPMDEDSLDRWEGVSLGIYRRARVRVQTLDREESAWMFVLNGYEGGLPAARYLGEIADAAESAGAPHDYVMELRKRPC
>NZ_CP049838.1|WP_171399105.1|6256598_6258047_+|NAD(P)H-quinone-dehydrogenase
MEYVTRIVIIGGGPGGYEAALVAAQLGAEVTVVDCDGLGGASVLTDCVPSKTLIATAEVMTTFDSSYEELGIIVADDTPPLEQAARVVGVDLGKVNRRVKRLALAQSHDITASVTRAGARVLRGRGRLAGMQALDGSRKVVVSAADGTEETLTADAVLLATGAHPRELPDAQPDGERILNWTQVYDLGELPEELIVVGSGVTGAEFAGAYQALGSKVTLVSSRDRVLPGEDPDAAAVLEDVFRRRGMNVMARSRAESAKRVGDRVEVTLSDGRVITGSHCLMAVGAIPNSEGMGLEEAGVKVRESGHIWTDKVSRTTAPGVYAAGDVTGIFALASVAAMQGRIAMYHFLGDAVAPLNLKTVSSNVFTDPEIATVGYSQADVDGGKIDARVVKLPLLRNPRAKMQGIRDGFVKIFCRPGTGIVVGGVVVSPRASELIHPISIAVDNNLTVEQIANAFTVYPSLSGSIAEVARQLHTRKTTGEV
>NZ_CP049838.1|WP_078889947.1|6258235_6259201_+|DeoR/GlpR-transcriptional-regulator
MFAAERRQLILEMVRANGAVSLRELARVVQTSEVTVRRDVRALEAEGLLDRRHGGAVLPGGFTRESGFPQKSHLATAEKTAIADLAANFVEEGEAIVVGAGTTTQELARRLARVPGLTVVTNSLLVAQALAHANRVEVVMTGGTLRGSNYALVGSGAEQSLQGLRVSRAFISGSGLTAERGLSTSNMLSASVDRALVQAAAEVVVLADHTKLGTDTMFQTVPTDVITRLVTDEPPAHDDRAATELQALADQGVQIAVAGASGSPGGDAVPARHQQQRRDVPLPAPRRGQVPGAAAGLRAASMLGEQAPGGERARVADLRRR
>NZ_CP049838.1|WP_171399106.1|6259964_6261737_-|biotin/lipoyl-binding-protein
MRKVLIANRGEIAVRVARACRDAGIASVAVYADPDRDALHVRAADEAFALGGDSPATSYLDIEKVLNAARESEADAVHPGYGFLSENADFAQAVLDAGLIWIGPPPQAIRDLGDKVAARHIAQRAGAPLVAGTPDPVSGADEVVAFAEEHGLPIAIKAAFGGGGRGLKVARTLEEVPELYDSAVREAVAAFGRGECFVERYLDKPRHVETQCLADSHGNVVVVSTRDCSLQRRHQKLVEEAPAPFLSEAQVAELYASSKAILKEAGYVGAGTVEFLVGVDGTISFLEVNTRLQVEHPVTEEVAGIDLVREMFRIADGEELGYGDPELRGHSFEFRINGEDPGRGFLPAPGTVTTFAAPSGPGVRLDAGVESGSVIGPAWDSLLAKLIVTGATREQALQRAARALAEFQVEGMATAIPFHRAVVRDPAFAPELTGSQDPFTVHTRWIETEFVNEIPAFSAPADSEAEDDTDRETIVVEVGGKRLEVSLPSSLGMSLARTGLAAGAKPKRRAAKKSGPMASGDTLASPMQGTIVKIAVEEGQEVKEGDLIVVLEAMKMEQPLNAHRSGTIKGLAAEVGASITSGAAICEIKD
>NZ_CP049838.1|WP_171399107.1|6262110_6262605_+|hypothetical-protein
MVRRPVAWIVAVVLFAEALGVAALNWFMGVVVDRQDMSLAGMDPDVMSTSSKVGGILFGLYFGLCAVVALLVALRDRAPAGLGRVLLISAAVVHALLGAFAWGLLGWTQFLFMVVVLALIVLLLMTYDAQQRPVAPQPEDSKGDGGGPPVAPAPVTPPTAPTTP
>NZ_CP049838.1|WP_171399108.1|6262573_6263179_-|septum-formation-inhibitor-Maf
MRRLVLASQSPARLNLLRQAGLAPEVIVSGVDEDAVTAPTPADLALALAEAKASVVAAKPEVKGALVIGCDSVLDLDGEALGKPADAAEATARWKAMRGRAGTLQTGHCVYDTVSGRYTSATASTVVRFGEPTDEEIAAYVASGEPLYVAGAFTLDGRSAPFIEGIEGDHGNVIGISLPLVRRLLAQLGVGITELWAPSEA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP049838_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049838_16

6474794-6474887

Orphan

Consensus_repeat	Method
CGCGCCCCTGGGGGTGGTTCCGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049838_16

>merge|NZ_CP049838|16|6474794-6474887|CRISPRCasFinder
CGCGCCCCTGGGGGTGGTTCCGGCTGTCGTGTCGGGTGCGGGGCCGTCGTGGCTGGTCGCGCAGTTCCCCGCGCCCCCTGGGGGTGGTTCCGGC

>NZ_CP049838|16|11|6474794-6474887|CRISPRCasFinder
CGCGCCCCTGGGGGTGGTTCCGGC	TGTCGTGTCGGGTGCGGGGCCGTCGTGGCTGGTCGCGCAGTTCCCC
GCGCCCCCTGGGGGTGGTTCCGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049838.1\|WP_171399267.1\|6471432_6472413_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_CP049838.1\|WP_171399272.1\|6476809_6480172_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276938
NZ_CP049838.1\|WP_171399276.1\|6483694_6485650_+\|FAD/NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|379196
NZ_CP049838.1\|WP_171399268.1\|6472445_6473507_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_CP049838.1\|WP_171399263.1\|6463422_6465666_+\|ABC-transporter-family-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173866
NZ_CP049838.1\|WP_171399269.1\|6473554_6474676_+\|dipeptide-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|236898
NZ_CP049838.1\|WP_171399279.1\|6488508_6490974_+\|protein-kinase/lanthionine-synthetase-C-family-protein	unknown	unknown	gnl\|CDD\|271199
NZ_CP049838.1\|WP_171399277.1\|6485650_6486325_+\|2OG-Fe(II)-oxygenase	unknown	unknown	gnl\|CDD\|379319
NZ_CP049838.1\|WP_171399261.1\|6459990_6461928_-\|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit	unknown	unknown	gnl\|CDD\|236101
NZ_CP049838.1\|WP_171399278.1\|6486426_6488025_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP049838.1\|WP_171399262.1\|6461945_6462779_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_054242666.1\|6462813_6463104_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171399275.1\|6482849_6483698_+\|DUF692-domain-containing-protein	unknown	unknown	gnl\|CDD\|377459
NZ_CP049838.1\|WP_171399266.1\|6469503_6471309_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173871
NZ_CP049838.1\|WP_171399273.1\|6480178_6480964_-\|AfsR/SARP-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|276938
NZ_CP049838.1\|WP_171399274.1\|6481884_6482694_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171399265.1\|6468403_6469438_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_CP049838.1\|WP_171399270.1\|6475160_6475901_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379312
NZ_CP049838.1\|WP_171399271.1\|6475998_6476505_+\|DinB-family-protein	unknown	unknown	gnl\|CDD\|368218
NZ_CP049838.1\|WP_171399264.1\|6465824_6467732_+\|translational-GTPase-TypA	unknown	unknown	gnl\|CDD\|273597

Protein	Function_ID	Function_description	E-value
NZ_CP049838.1\|WP_171399267.1\|6471432_6472413_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.69981e-90
NZ_CP049838.1\|WP_171399272.1\|6476809_6480172_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	3.77948e-37
NZ_CP049838.1\|WP_171399276.1\|6483694_6485650_+\|FAD/NAD(P)-binding-protein	gnl\|CDD\|379196	pfam13454, NAD_binding_9, FAD-NAD(P)-binding.	4.64937e-27
NZ_CP049838.1\|WP_171399268.1\|6472445_6473507_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	4.7376e-176
NZ_CP049838.1\|WP_171399263.1\|6463422_6465666_+\|ABC-transporter-family-substrate-binding-protein	gnl\|CDD\|173866	cd08501, PBP2_Lpqw, The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold. LpqW is one of key players in synthesis and transport of the unique components of the mycobacterial cell wall which is a complex structure rich in two related lipoglycans, the phosphatidylinositol mannosides (PIMs) and lipoarabinomannans (LAMs). Lpqw is a highly conserved lipoprotein that transport intermediates from a pathway for mature PIMs production into a pathway for LAMs biosynthesis, thus controlling the relative abundance of these two essential components of cell wall. LpqW is thought to have been adapted by the cell-wall biosynthesis machinery of mycobacteria and other closely related pathogens, evolving to play an important role in PIMs/LAMs biosynthesis. Most of periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the LpqW protein. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	7.85416e-88
NZ_CP049838.1\|WP_171399269.1\|6473554_6474676_+\|dipeptide-ABC-transporter-ATP-binding-protein	gnl\|CDD\|236898	PRK11308, dppF, dipeptide transporter ATP-binding subunit; Provisional.	6.06271e-146
NZ_CP049838.1\|WP_171399279.1\|6488508_6490974_+\|protein-kinase/lanthionine-synthetase-C-family-protein	gnl\|CDD\|271199	cd04791, LanC_SerThrkinase, Lanthionine synthetase C-like domain associated with serine/threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown.	1.29884e-45
NZ_CP049838.1\|WP_171399277.1\|6485650_6486325_+\|2OG-Fe(II)-oxygenase	gnl\|CDD\|379319	pfam13661, 2OG-FeII_Oxy_4, 2OG-Fe(II) oxygenase superfamily. This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily.	3.73938e-10
NZ_CP049838.1\|WP_171399261.1\|6459990_6461928_-\|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit	gnl\|CDD\|236101	PRK07803, sdhA, succinate dehydrogenase flavoprotein subunit; Reviewed.	0
NZ_CP049838.1\|WP_171399264.1\|6465824_6467732_+\|translational-GTPase-TypA	gnl\|CDD\|273597	TIGR01394, GTP-binding_protein_TypA/BipA_homolog, GTP-binding protein TypA/BipA. This bacterial (and Arabidopsis) protein, termed TypA or BipA, a GTP-binding protein, is phosphorylated on a tyrosine residue under some cellular conditions. Mutants show altered regulation of some pathways, but the precise function is unknown. [Regulatory functions, Other, Cellular processes, Adaptations to atypical conditions, Protein synthesis, Translation factors].	0
NZ_CP049838.1\|WP_171399278.1\|6486426_6488025_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	9.98369e-103
NZ_CP049838.1\|WP_171399266.1\|6469503_6471309_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173871	cd08506, PBP2_clavulanate_OppA2, The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold. Clavulanic acid (CA), a clinically important beta-lactamase inhibitor, is one of a family of clavams produced as secondary metabolites by fermentation of Streptomyces clavuligeru. The biosynthesis of CA proceeds via multiple steps from the precursors, glyceraldehyde-3-phosphate and arginine. CA possesses a characteristic (3R,5R) stereochemistry essential for reaction with penicillin-binding proteins and beta-lactamases. Two genes (oppA1 and oppA2) in the clavulanic acid gene cluster encode oligopeptide-binding proteins that are required for CA biosynthesis. OppA1/2 is involved in the binding and transport of peptides across the cell membrane of Streptomyces clavuligerus. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	2.74399e-166
NZ_CP049838.1\|WP_171399273.1\|6480178_6480964_-\|AfsR/SARP-family-transcriptional-regulator	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	4.43786e-31
NZ_CP049838.1\|WP_171399265.1\|6468403_6469438_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	4.66239e-73
NZ_CP049838.1\|WP_171399270.1\|6475160_6475901_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	2.58185e-17
NZ_CP049838.1\|WP_171399275.1\|6482849_6483698_+\|DUF692-domain-containing-protein	gnl\|CDD\|377459	pfam05114, DUF692, Protein of unknown function (DUF692). This family consists of several uncharacterized bacterial proteins.	6.44022e-90
NZ_CP049838.1\|WP_171399271.1\|6475998_6476505_+\|DinB-family-protein	gnl\|CDD\|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	2.55263e-41

>NZ_CP049838.1|WP_171399269.1|6473554_6474676_+|dipeptide-ABC-transporter-ATP-binding-protein
MKKEELVLPAPREAGADGEGEQLLVVQGLTKHFPVKGGFPIRRTVGQVQAVDGIDLSVRAGESFGLVGESGCGKSTTGRLITRLLEPTAGTITYRGQDISHASRRQLAPIRSEIQMIFQDPYSSLNPRQTVGKIISGPMEVNGIEPAGGREKRVRELLEIVGLNPEHYNRFPHEFSGGQRQRIGVARALALEPKLIVADEPVSALDVSIQAQVVNLLQQVRQELGIAFLFIAHDLAVVRHFSQRVAVMYLGKIIEVGDRDSIYTRPRHPYTHALLSAVPEVNVAGGEAASRERIRLAGDVPSPIAPPSGCRFRTRCWKAQDKCAAEEPPLVQISGNHEGHLTACHFPEEPTIEGREEDIVLDPALAALEEGNG
>NZ_CP049838.1|WP_171399268.1|6472445_6473507_+|ABC-transporter-ATP-binding-protein
MTTVTKEAGAPVPAGAGAFLSVRDLHVSFTTEDGAVRAVDGLSFDLERGRTLGIVGESGSGKSVTNLTVLGLHNPMFTTVEGEILLEGQELTTARESELEKLRGNKVAMIFQDPLTALSPYYTVGRQIAEPYMKHRGASKKAAWERTVEMLGKVGIPNPRERAKDYPHQFSGGMRQRAMIAMALVCDPDLLIADEPTTALDVTVQAQILDLLKDLQREFGTAIIFITHDLGVIADMADDIMVMYAGGAVERGTTEQVLRSPQHPYTWGLLNSMPRLDSDLGTPLAPIPGAPPSLLNPPSGCRFHPRCTFRDRVGGNRCVTERPLLAPDRASACHLTAEQKRTIFMDEIKPRLG
>NZ_CP049838.1|WP_171399267.1|6471432_6472413_+|ABC-transporter-permease
MLRFLLRRALGSLVILVLLTVVAFLLFFGMPRDPALLMCGKTCTPDALANIHRTLGIDKSVPEQFWIFLQGLVAGRDDFAQGPCPAPCFGYSYHTNEQVWSTLMDRLPLTVSLALGATVVFLFVGLGTGMLAAWRRGTLIDKSFTAGSMVLSSMQIYFLGPLALAVLVYQTHIFDEPRYTELTQDPVAWFTGLMIPWVVLSTIFAAQYTRMARSSMIEQLQEEHIRTARAKGMSRRYVFFRYAWRGSLIPIVTILGIDLSSMLGGAIITEYTFGLPGLGHLAVESVQFSDLPLLLGVMLFAAAVILLCNIVVDAAYAFIDPRVRLS
>NZ_CP049838.1|WP_171399266.1|6469503_6471309_+|ABC-transporter-substrate-binding-protein
MGKGGRRAYAALSLVAAGALVLSGCSEGGSKEGSNKDDKENAQRQQSSIDFGDVKASTGPAAEVPGAKPGGAVTVLQRDSYAHIDPAQIYVSDEMALSQLIHRGLTGYKATSEDGKKHEVVGDLATDSGTSTDGGKTWKYTLKDGIKWADGSAITATDVRHTFERLFAPFVANGPTYIQQWLADTPGTEYRNLLKDGPYGGKHLPDTILETPDAKTVVFKFKKPKPDLPYALAMAGYSLVSKAKDTKEKYDKAPMTSGPYKIQDFKSGKSMVLVKNTNWDPKTDPIRHQYIDQFTFAFNKQFEDSTKAILDDSGANATAVSFNNEVDAGNLSKILADATLKSRTVSGYQPYVGQIDINMSQKEMQDKTVREAIAYALPITPFVRAFGGTAAREVAGGLISPTVSGYNPNFDPFGKKKKPAGDPAKAKELLEKAGKTGLKLTFGYINTPEGQQYSTAMAAGLEKAGFDVQRQEIPAETYYDQVGKVSNNFDIYHTAWGADWPSSSTVIPPLYDGRQIQDGAANYSHINDPKVNADIDKASTITDPIKAAEAWNKINEYIVKDVVSNIPTAYYKQTQIAGSKIGGLVYDDVIGGIDPRRLFVK
>NZ_CP049838.1|WP_171399265.1|6468403_6469438_+|ABC-transporter-permease
MTSPTDIEGGGTSVVVDGDQEPRPAPEAKVPVGRSPGQLMWLRFKRDRTGVISAYVVLLFFLVGLLAPLISKLYGNNPYTVYADERPELFDSAGVPVQPNGGISGEFWFGLEPGNGYDVFTKLLYGIRNSLGISLAVTLATVLTGIVLGVAAGYLGGRTDFLISRVIDFLLAIPAQLFFIASMPVVVSLFVSPRDETPVYVRVVALISVQWVLGWMSLGRILRGTSLALREREFIEAAKVSGAPPGRIIRKEILPNVVTPILVQATYMLPNFVTAEAGLSFLGVGLVEPTPDWGQMFSKAATELVMQNDITYMFFPGVSMIIFIVAFNLLGDSVRDAFDPKTAR
>NZ_CP049838.1|WP_171399264.1|6465824_6467732_+|translational-GTPase-TypA
MATRHDIRNVAIVAHVDHGKTTLVDAMLKQAGAFAAHAAESLDDRMMDSNDLEREKGITILAKNTAVKYHPKDGGDVITINIIDTPGHADFGGEVERGLSMVDAVVLLVDASEGPLPQTRFVLRKALQQRLPVILCINKTDRADSRIDEVVNETYDLFLDLDADEDQIEFPIVYACARDGVASLTKPEDGTVPQDSDSLEPFFSTILSHVPAPEYDEEAPLQAHVTNLDADNFLGRIALLRVEQGELRKGQTVTWIKRDGTLSNVRITELLMTEALTRKPAEMAGPGDICAVAGIPDIMIGETLADPENPIALPLITVDEPAISMTIGTNTSPLVGRGGTGKGASAKAAVKDRKVTARQVKDRLDRELVGNVSLRVLDTERPDAWEVQGRGELALAILVEQMRREGFELTIGKPQVVTQEIDGKVHEPVERMTIDVPEEHMGAVTQLMGVRKGRMDNMSNHGSGWVRLEFVVPSRGLIGFRTEFLTGTRGTGIAHSIHEGHEPWFGVLTTRNNGSLVADRAGAVTAFAMTNLQERGVLFTDPGTEVYEGMIVGENSRADDMDVNITKEKKLTNMRSAAADSFEAIVPPRKLSLEQSLEFCRDDECVEVTPEAVRIRKVVLDQRDRARTASRAKHG
>NZ_CP049838.1|WP_171399263.1|6463422_6465666_+|ABC-transporter-family-substrate-binding-protein
MSHDGVGPRAVMRSVAFLTAGALAVPLLSGCGSADEAGKPLARQDIAPAGRAQVAEGGTLRWAVDAVPDTFNTFQSDADATTTRVAQAVLPSMYRLDATGRPQRDSDYLESAKVVDTEPKQVVLYKLNQQAVWSDGREIGAADFAAQWRALAGKDSAYWTARNAGYERIEKIERGANDLEVRVTFKRTYADWRSLFSPLYPKDVMGTPDAFNDAARRKLKVTAGPFVVKKVDRKKDQVRLTRNTRWWGRPAKLSEIVLTAVPRDERASALAEGKIDLAEIDPATVQRIDGAANGTAGPLAGPGSGRTAAKALRSWALAHGSDEDTAEDEVEARTELSKAIAKWEQQQEALRDFEVRRSLEPAYTQLALNGADGLLADERVRRAVARALDRRELAEVVLKPLGLPAEPVGSHLALAGQDAYADNSGALGGQDTTEAQALLADAGWVPGGPVKKQEKGEKAAGSEGKKAGSKESDSDDDSADGDGTYIVGADDKARAGTDHEEKRDVTKGESAGRDDDGPRQLAQDGKQFKQVHQGGAPGAYAPKGTAAPAGAPAKALAKDGKALSLRFVLPSGPGSEPLAAVAARITRMLAKVGIGTDITKVSDESYFKDHIASGQYDLALYSWPASAFPATDARPIYAKPVPAADGSLSVEQNYTRIGTDQVDQLFERAVSTLDDGEKRSLIRKADSRIWAAAGSIPLYQRPQLTAVRKNVVNAGAFGFQTPVYEDMGFLKKGAKKGAKASASPSEK
>NZ_CP049838.1|WP_054242666.1|6462813_6463104_-|hypothetical-protein
MSVHDDLTTAQRCLDDLSRSVGRLEQQLGSTGLEMRRVRADADHLRESVALLREAASQPGSSRRPELVTIPDTPYDDSLWIDTDDEGLGARGRHAP
>NZ_CP049838.1|WP_171399262.1|6461945_6462779_-|hypothetical-protein
MATGTEPSPTDHRPPSGVRGAGRAAIAAPHLRTDRWWLAPAATAAGLLAFVVYSTWRAFANADYYAAPYVSPLFSPCLAENCQTMRSGPNWDLFGSWWSLSPAIIILIFPLGFRLTCYYYRKAYYRGFWASPPACAVAEPHKKYTGETRFPLILQNVHRYFFYAAIVVAGILTYDTALAFRDEHYAWGHMGLGTLVFLVNIVLIWAYTISCHSCRHIVGGQLKHFSRHPVRYRAWRFVGKLNAHHMLLAWVSLVSVSLADLYVYLVASGAFDDPRFF
>NZ_CP049838.1|WP_171399261.1|6459990_6461928_-|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit
MSVVDRQEWDVVVVGAGGAGLRAAIEARERGARTAVICKSLFGKAHTVMAEGGIAAAMANANEHDNWQVHFRDTLRGGKFLNQWRMAELHAQEAPDRVWELETWGALFDRTKDGRISQRNFGGHEYPRLAHVGDRTGLELIRTLQQKIVSLQQEDHRETGDYESRLKVFQECTVTRVLKDGSRVSGVFAYERETGRFFVLQAPAVVIATGGIGKSFKVTSNSWEYTGDGHALALLAGAPLLNMEFVQFHPTGMVWPPSVKGILVTESVRGDGGVLRNSEGKRFMFDYVPDVFKEKYAESEEEGDRWYEDPDHNRRPPELLPRDEVARAINSEVKAGRGSPHGGVFLDVSTRMPAEVIKRRLPSMYHQFKELADVDITAEAMEVGPTCHYVMGGIAVDSESAAARGVPGLFAAGEVAGGMHGSNRLGGNSLSDLLVFGRRAGLHAAQYTAGAGAGRPEVDDEQVDAAAAEALRPFSAEGPGDQADHAPENPYTLHQELQQTMNDLVGIIRREGEMEHALEKLAELRVRAWRAGVEGHRQFNPGWHLALDLRNMLLVSECVARAALERTESRGGHTREDHPTMDRAWRNVNLLCAPVEPTDGPAATDPVRGRIALTRETTEPIRPDLLALFEKEELVKYLTEEELYE
>NZ_CP049838.1|WP_171399270.1|6475160_6475901_-|methyltransferase-domain-containing-protein
MVDHSFADLTLAALYDSINPWGPDDDFYLNLVRSADSVLDVGCGTGRLLARAASDGHPGRLTGLDPAAAMLVQARRRAPGVEWLLGDLTTRLWQGDFDLVVMTGHAFQVLLGDEELRGALRAVRSALGDGGRFVFETRNPGARAWETWTPDRVREVTDADGRVVRVWHEVADEPSGDRVTFTETFDSPGWPRRHTGRATLRFLTPGSLTGFLAEAGLRVEEQYGNWDRRPLTRTSPEIITVATPSE
>NZ_CP049838.1|WP_171399271.1|6475998_6476505_+|DinB-family-protein
MTRTDDMPSAWDERTQLTTFLDYARDTARAKCEDLSDTDAARAPLPGSPLMTPSGLVNHLRWVEYYWFRVVFLGEEDEGPWTDEDPDREMRIAVDLPLAQVLDEYAEHAERHRKLVAEHDLDTTAQRATRDGRHVDLRWILLHLIEETARHNGHLDILRELIDGRTGV
>NZ_CP049838.1|WP_171399272.1|6476809_6480172_+|tetratricopeptide-repeat-protein
MLTPRPRFRLLGPLDVEIDGRVVVLTGRQRALCAVLLLHANHVVSVDRLIQCLWDDRPPGAGAARVRALVAEVRRALGPAGTELLTTRRPGYVMHAGPDELDLLAFENLIRDASRAAADGDWRTARRSGEQALALWRDEPLSDLSEVAVREAERQRLAELHLVAREGVAEAGIETGRHREAIAELLRLTAAHPLRERPHGLLMRALHQDGRSAEALELYTALRRRMVDELGMEPSADLRDLHQRLLRGGGVSAGAPPERPAPASERPVPRQLPPTPRRFVGRDRELDRLESCLRTSEPLALIVGPAGVGKSALALNWAHRVADRFPDGQLFLDMRGFDNAEPMTPGEALPLLLQGLGCAPRDIPLGAEAQTALYRTLLADRRVLVVLDDVADASYVRRLLPASAGSLTLVTSRDKLSGLVTLDGAYRVSCDVLDSAAALELISGAVGVEAVAADPEAAAQLVELCDHLPLALCVAGSWIGDRPGSIRAYVRDLADRGRLARLHVEGEESVAVRAALDLSYGVLPEEARRAFRSLGALPGTGRSVPAAAAAAGTDEHRLADLLRLAQRVHLLRDVEHGRPAWHDLVHEYARDRTAAEDSPEERAAAVTRVLDHYLQSVVNAAATAGLYVMRTRPPAVEGSLPREFAGPEEAYAWFDGEWDDIAAAIGHAAEHGPAPYVWWLVDALQDLFHHRRPLSDWMRLATLAREVAARGGDEVGQASMCLSLGSARWRNGDLRGALTEYEEAEELARRAGWTYGEAGSLQGKGVTLKLLGELRRALPCYDRALALYRTLDNVKNVEIMLINTASLNLALGRLDAAEEAACAALDLIGDTVHHNRAMALVNLALVRQKQARFDEATAALRTCFLVSRDSGSTYTEAVALEALGRVRADSGRDDRALLAYEDALAVSRRVENRNCQVDSLVGVASVKLRAGRAEETAEHLDAAFEIAEHTGHRAGLVEVLLARADLARAQGRPADALDHLERAERLAADGNPLTLPRVHLTTALTLLDTDTDTDTDTDDTAITRARDAATLAAALARSSGQRLLHARATAALASAHEAHGDTGPAHEARTEATALYATLGVRHPPGAPAPHRPLPHHRHRELPPDAESRLTLYLTEHFDG
>NZ_CP049838.1|WP_171399273.1|6480178_6480964_-|AfsR/SARP-family-transcriptional-regulator
MEIQLLGCVEARARSGDKLPLPHGTKLLLAALAWTPGTFVADETLIERVWQERRPQHPRDALYIQATRLRKALRADGQLTEGFELIRKRGGYVLAIDERRVDTARFRALVRQAQQEARAGDTETALGLYTRALELWRGEPLSDVRTAWAESTRVTLRREHREALVGSSELYLRVGRHEECLPQLHWLAEMHPFDEKVTGLLMLALHRGGRQADALDCFQLLRLRMIDLLGCEPGPELRSLHERILARDPRLRLGSAYATSV
>NZ_CP049838.1|WP_171399274.1|6481884_6482694_+|hypothetical-protein
MLFKIYLNPGYRLAHRMDPGSFADLMGLSGANADLVRNLSPSEAEQFADGLKWKQLDSLNVHMPTTYRWLQTARPEILREFQENSTFSRLAQWGGPAKQLVDFVRECHDFYDGVPAALSDVAQLEFLLMSARREQEMRSGRTDGSAPAPSVFSWASLYWKPSYTSLAHFSVDAFAILLGKKEMVDEGDPIWVVIAPSHSGRMPTILRVAEPAYRLLGEMGEPVTAGKLLEYAREQGLNVSAQALQALLSRLAQSRAIGSYHLRDENVGV
>NZ_CP049838.1|WP_171399275.1|6482849_6483698_+|DUF692-domain-containing-protein
MASNHSTDSPISVSGAGLGYRKELSNEFSLHSAEIDVVEILADQWFGYDNPRRLREVADEFSTVLHGVGMSLAGAGRIPDDYLEEIRKVTDACGASYYSEHLAMTHVPGADAGHLCPPVISEEGLRACIRNVDRAQTALGVPLALENITYSFSLGADHVDAATFFTQLVAATGCYMLLDVANLYINSKNHSFDPLSYLDKLPTDRIVQVHLAGGVVTSTGQHIDSHSETIGDEIWRLAADTAERCSPSAVIVERDDNFPDFEALIKEVAMARDIFFPKAERR
>NZ_CP049838.1|WP_171399276.1|6483694_6485650_+|FAD/NAD(P)-binding-protein
MIEVAVRGHPYVVAVVGVGLYGLSTLERLVANIPEYVPKKDREIHIHLIDPCLDRGSRTWAVDQPSELWMNSHAGMMTLFTDDSSSCEGPVRKGPTLQEWAASAGEVLSSDETLNGLVDAFSPYRWASRSVMGKYMGWFLDHVVQNAPSNVRIHRHGKLAVEVSSASDSLQEGESVKLADDPVPLVCHRVILAQGRPATEPTPEQQELRRTMSSYGGSHEPPGQASLSKTAHIKPGDRVLLRGLGLTFFDYLQLLTTVRGGTFHRAANGSLTYEPSGNEPRIFAISRTGVLAHPVRWWPMTGSLVMCPVPRFTSPQIFSELALRCDTAVALKEATARMSSELLYFYYSDTLSADPERSSSAWHRFQQTYPSLEPGSPAQEELIASLFPMEERIDLDRMMDPLQGETFSTLESLQTWMRRHIAQITNRTLTKEHSRDLALRTALAYITASLQEASRSRGFEANPDFYKGIWDWAWAKMAILTGGAPWPRQLELQALSRCGVVTFLGKESGVAHAPEAGTVKCVSETVPVTVGIDHLIEARHSMPTVTQTSDALLRNLVQRGEISWRGFDRTSSPRAPGPQRVTVTRYGSLVTTDNRVSRTIYAVGADTSNPILTPGLPRVGTDSDVFHLTDRVARHLLESLIRGYPDTSTEE
>NZ_CP049838.1|WP_171399277.1|6485650_6486325_+|2OG-Fe(II)-oxygenase
MTPSFKTETYAVFDDFLSIDILRSVRDRMADERFVYLKNVWQPKNFYRLVEGDPLVGQTVYYNHPKVPKGFASHPSGKSADAVVEALLGAEESLATWIGLRGSAWDFFTCTPYLYPAGSGLSWHDDAKDRVGSYVLYVHDDWKSSWGAELLIATDVGDRRASVERYQGVNTDLGHYVTAVPNRLVVIKAGTPHAVRSVSTRAGENLRMSMTGFFQPLPQSLREA
>NZ_CP049838.1|WP_171399278.1|6486426_6488025_+|ABC-transporter-ATP-binding-protein
MALTMTSTVLLKRVVDVALPRHDVRLLSILCSVMLLAVVLTSLCMVVTARLNHTIGQGLVHRLRGDIFRATQRMPLEHFSTHSVSGVQTRIANDVEGISNVVTFAAQGMVASAAALVTSAAIMFILSWPIALVSLSVAVALNILNNRYAKKRRSLTHAQQGKASDMVHFIGEHLSLSGVLLGRTLGREHWQLERFEGMSREAADTAIQERLAGRTALATISMTLAVLPILAYWAAGTVLHGISLGAVIVITALQAQISMPIQQLMQLSADVQSSRALFERIFHLIDLPDSSPRQQASIAEAKQRAPVADIRVIDAEFSYAGRTGKALDSINLTLPAGSRVFVTGESGSGKSTLALLLAGLITPQAGSVSAYWASGHAAESVRAVATLVPQESTLFNLSIRENLAFGDPSCTLERMTAALRTVELDRLLARLPDGLDTIVGDRGAKVSGGERQRIAVARALLADYPILVFDEFSSGLDGATSEAVFEGLLQRIQDKTLIVVAHRLPTLREGDTILTMHAGRVTEVSTWQGARR
>NZ_CP049838.1|WP_171399279.1|6488508_6490974_+|protein-kinase/lanthionine-synthetase-C-family-protein
MLDFRFLEFCRPDKIFYDVPDTEKAEDDFEVSLPQGWGIERGRDWTVCRPSDPTGRPEQGWKIHVAGTLDTAHELLGAVVPYLVERGVMFKFIRSAAVLRRRNSKNGERTASGKFITVYPHGDRHTEQLLHGMEELVGGTPGPYILTDLRWKQGPLYVRYGAYVWKSTRDVRGVMVPAMTGPDGSLVPDERRPVFRPPSWLEIPAFLHEALEARKQGTLADFPFRIRAALHFSNGGGIYRATEIGTGRDVLLREARPWAGVDAEWGDAVTRMKREHWALERLRGLPCIPEVIAYVTGHEHDYLAREYVEGASLTPLMATRHPYATGDRSAEACRAYRTWALNVLRRVEDGLNAMHERGVVFGDLSLANVLVTDSDQVRFIDLETATPADEAKPQTLGSLGFRAPEHLTGCDIDRYALAVLKLALFIPVPQAVPWGARKVRQLVDQMVRDFEVPAEFVDSILAWLSPENLPTRNECAVTWPERAEHSDLEARIAGSVVAAATTDRMDRLYPGDPMQFMNPGGGIAFAFGAAGTLWALSRTGHTVPADHVQWLVDRVKTGEDGDGPGFTGGLAGLSHALDALGEHELATDVLERALARADEQGVTDSFATGRSGLALAALFHHQVTRDAKWLDAAVDLAARMEQGPHHARRVGLLHGRTGPALLHMHLHRATGDPASLAWAAAELSRDLQILNRARRIGPGLDGTGGMAVVARAAVRFGADELRDAHEKLVRSLDQIATGFGLWGGRAGTVLARADHGLPTDAHVHSLGWDAVFLRDDSVDFIGDRRFRLSTDLSTGSVAALLALASTREQTTVFPFLGRDLE

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP049838_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049838_17

6550004-6550217

Orphan

Consensus_repeat	Method
GGCGGCCGTCTTGCGGGTGCGGCGCGGCTTGGCCACGGTC	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP049838_17

>merge|NZ_CP049838|17|6550004-6550217|PILER-CR
GGCGGCGGTCTTGCGGGTGCGGCGCGGCTTGGTGGCTTCCGCTTCCTGGGTGGCCTGGGCCGGGATGTCGGCCGTGGTGGCCGTCGTCTCGGGCGCGGTGGCCTTGCGGGTGGTGCGGCGGGGCTTGGCCTCGGTCGCTTCGGCCGTGTCGACGGCGGCTTCGGCCGGGGCCGCGGCTGCCGTCTTGCGGGTGCGACGCGGCTTGACCACGGTC

>NZ_CP049838|17|2|6550004-6550217|PILER-CR
GGCGGCGGTCTTGCGGGTGCGGCGCGGCTTGGTGGCTTCC	GCTTCCTGGGTGGCCTGGGCCGGGATGTCGGCCGTGGTGGCCGTCGTCTCGGGCGCGGTGGCCTTGCGGGTGGTGCGGC
GGGGCTTGGCCTCGGTCGCTTCGGCCGTGTCGACGGCGGC	TTCGGCCGGGGCCGCGGCTGCCGTCTTGCGGGTGCGAC
GCGGCTTGACCACGGTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049838.1\|WP_171399334.1\|6558269_6559988_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173871
NZ_CP049838.1\|WP_020130830.1\|6554254_6554896_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP049838.1\|WP_171399332.1\|6555536_6556514_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP049838.1\|WP_171399321.1\|6540825_6541956_-\|magnesium-and-cobalt-transport-protein-CorA	unknown	unknown	gnl\|CDD\|213364
NZ_CP049838.1\|WP_171399335.1\|6561038_6562046_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_CP049838.1\|WP_171399329.1\|6552616_6553354_+\|tRNA-2-methylthio-N6-isopentenyl-adenosine(37)-hydroxylase-MiaE-like-protein	unknown	unknown	gnl\|CDD\|205967
NZ_CP049838.1\|WP_171399320.1\|6540273_6540792_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171399326.1\|6547025_6547178_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171399324.1\|6544488_6545130_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171399330.1\|6553385_6553655_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171399323.1\|6543093_6544317_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341027
NZ_CP049838.1\|WP_171399331.1\|6555076_6555295_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_020127905.1\|6546326_6546932_+\|MarC-family-protein	unknown	unknown	gnl\|CDD\|225006
NZ_CP049838.1\|WP_020130831.1\|6553880_6554108_-\|DUF3107-domain-containing-protein	unknown	unknown	gnl\|CDD\|378634
NZ_CP049838.1\|WP_171399333.1\|6556821_6557916_+\|DUF3152-domain-containing-protein	unknown	unknown	gnl\|CDD\|371483
NZ_CP049838.1\|WP_171402228.1\|6560031_6561042_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_CP049838.1\|WP_171399322.1\|6542447_6543032_+\|suppressor-of-fused-domain-protein	unknown	unknown	gnl\|CDD\|377450
NZ_CP049838.1\|WP_171402227.1\|6547374_6548271_+\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350235
NZ_CP049838.1\|WP_171399325.1\|6545414_6546272_+\|PHP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223686
NZ_CP049838.1\|WP_171399327.1\|6548293_6549175_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669

Protein	Function_ID	Function_description	E-value
NZ_CP049838.1\|WP_171399323.1\|6543093_6544317_-\|MFS-transporter	gnl\|CDD\|341027	cd17474, MFS_YfmO_like, Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily. This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.04895e-91
NZ_CP049838.1\|WP_171399332.1\|6555536_6556514_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.66395e-26
NZ_CP049838.1\|WP_171399321.1\|6540825_6541956_-\|magnesium-and-cobalt-transport-protein-CorA	gnl\|CDD\|213364	cd12830, MtCorA-like, Mycobacterium tuberculosis CorA-like subfamily. This bacterial subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporter Mycobacterium tuberculosis CorA (which also transports Co2+). Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.	1.30109e-169
NZ_CP049838.1\|WP_171399335.1\|6561038_6562046_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.77286e-93
NZ_CP049838.1\|WP_171399329.1\|6552616_6553354_+\|tRNA-2-methylthio-N6-isopentenyl-adenosine(37)-hydroxylase-MiaE-like-protein	gnl\|CDD\|205967	pfam13794, MiaE_2, tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like.	2.24303e-92
NZ_CP049838.1\|WP_171402228.1\|6560031_6561042_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	5.05811e-77
NZ_CP049838.1\|WP_020130831.1\|6553880_6554108_-\|DUF3107-domain-containing-protein	gnl\|CDD\|378634	pfam11305, DUF3107, Protein of unknown function (DUF3107). Some members in this family of proteins are annotated as ATP-binding proteins however this cannot be confirmed. Currently no function is known.	1.51375e-34
NZ_CP049838.1\|WP_171399325.1\|6545414_6546272_+\|PHP-domain-containing-protein	gnl\|CDD\|223686	COG0613, COG0613, Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only].	1.03597e-48
NZ_CP049838.1\|WP_020127905.1\|6546326_6546932_+\|MarC-family-protein	gnl\|CDD\|225006	COG2095, MarC, Multiple antibiotic transporter [Intracellular trafficking and secretion].	1.24594e-40
NZ_CP049838.1\|WP_171399334.1\|6558269_6559988_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173871	cd08506, PBP2_clavulanate_OppA2, The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold. Clavulanic acid (CA), a clinically important beta-lactamase inhibitor, is one of a family of clavams produced as secondary metabolites by fermentation of Streptomyces clavuligeru. The biosynthesis of CA proceeds via multiple steps from the precursors, glyceraldehyde-3-phosphate and arginine. CA possesses a characteristic (3R,5R) stereochemistry essential for reaction with penicillin-binding proteins and beta-lactamases. Two genes (oppA1 and oppA2) in the clavulanic acid gene cluster encode oligopeptide-binding proteins that are required for CA biosynthesis. OppA1/2 is involved in the binding and transport of peptides across the cell membrane of Streptomyces clavuligerus. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NZ_CP049838.1\|WP_171399333.1\|6556821_6557916_+\|DUF3152-domain-containing-protein	gnl\|CDD\|371483	pfam11350, DUF3152, Protein of unknown function (DUF3152). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	5.39302e-76
NZ_CP049838.1\|WP_171399322.1\|6542447_6543032_+\|suppressor-of-fused-domain-protein	gnl\|CDD\|377450	pfam05076, SUFU, Suppressor of fused protein (SUFU). SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumor-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems.	4.80222e-30
NZ_CP049838.1\|WP_171402227.1\|6547374_6548271_+\|NYN-domain-containing-protein	gnl\|CDD\|350235	cd10911, PIN_LabA, PIN domain of Synechococcus elongatus LabA (low-amplitude and bright) and related proteins. This subfamily contains Synechococcus elongatus PCC 7942 LabA which participates in cyanobacterial circadian timing, it is required for negative feedback regulation of the autokinase/autophosphatase KaiC, a central component of the circadian clock system, and appears to be necessary for KaiC-dependent repression of gene expression. This subfamily belongs to the LabA-like domain family which includes the N-terminal domain of limkain b1, a human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes. Also included in the LabA-like domain family are human ZNF451, uncharacterized Bacillus subtilis YqxD, uncharacterized Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously Pseudomonas putida S16 NicB , which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.74575e-06
NZ_CP049838.1\|WP_020130830.1\|6554254_6554896_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	3.20586e-16
NZ_CP049838.1\|WP_171399327.1\|6548293_6549175_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	8.99521e-14

>NZ_CP049838.1|WP_171399327.1|6548293_6549175_-|alpha/beta-hydrolase
MTRPSTSSPFPPPSGALSYPLRTERGEFAVVDAPVPAGVEQRGVALLMPGFTGSKEDFHRMHEPLAARGYRTIAVDGRGQNESDGPAVDESAYAREELAQDVLAQAAALDAPAHLVGHSLGGQIARAAVLLDHSPFASFTLVASGPAEISDSQKQRVKLLHDALAVMTMPEVWEAILAMGPPEEVGGPASGYGERELLRRRWLNHKPAQLLVTGRQLCVEPNRVGELAAVPLPFHVLSGARDDTWPVPLLDEMARELGAHRTVVPGAEHSPNQDQPLPTAHALADFWDRHPAL
>NZ_CP049838.1|WP_171402227.1|6547374_6548271_+|NYN-domain-containing-protein
MNDDLPALAARIDRTNELLTRMLAEVAKTPSTHAIFVDAGYLYAAAGRLVAGTEDRRAFDLDAEGLIEALIDRARSIFADSRLLRVYWYDGARRRIHTSEQQSIAELPDVKVRLGNLNANNQQKGVDSLIRTDLESLARHRAISDAALLGGDEDLVSAVEAAQGYGARVHLWGIEAPEGRNQAEPLLWEVDSQRTLDLDFFKPYVSRRIAPAYEGPGANRPTREAVRFVGAQVAAKWLAARGRESLAELLPGHPYLPGSVDQDLLVEAEGILQYSLRGQADLRRALRDGFWEHVQTQY
>NZ_CP049838.1|WP_171399326.1|6547025_6547178_-|hypothetical-protein
MRFEIMRLDDVDGTPVDCTVVDAASVNRIVQQAAAIGQRLWIRPADTSAS
>NZ_CP049838.1|WP_020127905.1|6546326_6546932_+|MarC-family-protein
MFDVAVFGSLFLTLFVIMDPPGITPIFLALTAGRPGKVQKRMAFQAVCVAGGVITVFGLLGHQILDYLHVSVPALMIAGGLLLLLIALDLLTGKTDEPKQTKDVNVALVPLGMPLLAGPGAIVSVILAVQKADSAAMQVSVWVAILAIHVVLWLVMRYSLLIIRVIKDGGVVLVTRLAGMMLSAIAVQQIINGITQVIRAG
>NZ_CP049838.1|WP_171399325.1|6545414_6546272_+|PHP-domain-containing-protein
MRIDLHCHSTASDGTDTPAELVRNAGAAGLDVVALTDHDTTRGYAEAVAALPRGLTLVTGAELSCRIDGISMHMLAYLFDPEEPALLAERELVRDDRVPRARSMVARLNELGVPVTWEQVARIAGEGSVGRPHVATALVELGVVPTVNDAFTGHWLADGGRAHVEKHETDPFEAIRLVKGAGGVTVFAHPSAGKRGRTVPESVIAELAAAGLDGIEVDHMDHDADTRARLRGLAADLGLLVTGSSDYHGSRKTCVLGEYTTDPEVYGEITRRATGAFPVPGTGGA
>NZ_CP049838.1|WP_171399324.1|6544488_6545130_+|hypothetical-protein
MRGEPSCPKCGGRVRAPGLFADSWQCDVHGTVHPLQPVIPPSVEALSVVVHRTQVPVWMPWPLPVGWLFTGVTYAGDDRSGGRATAVACSGPGPLGGMGELILVAEELGVGLGARYAGVDGPDPGPYMSVEKPPQAKVLAAGRPTPLWHVSATPDDRAVFAGEACGLWLWAVVWPEQSGLLMYDELVLTDLRDAGAELELVPCGALSPRLLKP
>NZ_CP049838.1|WP_171399323.1|6543093_6544317_-|MFS-transporter
MDPFDAGAGSILRQPKAVWATAGASVVAFMGIGLVDPILPSIAQGLDATAGQVSLLFTSYFLITAFAMLVTGFVSSRIGGRRTLLVGLALVVVFAALAGTSGSVGELVGFRAGWGLGNALFVSTALAVIVGAAAGGSAAAILLYESALGLGMACGPLLGALLGDASWRYPFFGTAFLMAIGFLCITVFLKDQPKPARKISVLDPIKALGHGGLASAAASAFFYNYTFFTVLAFTPFVLNMTPYKSGAVFFAWGVLLAVFSVLVAPRLQERFGSLKVLGGSLVLLAVDVFVLGYGDHTTAIVCTILSGAFIGVNNTVYTELALGVSDAPRPVASAGYNFVRWFAAAAAPYFAPKIEEWTDIHVPFVVAAVTALLGAVVVVVRRKALTHEAEELEPQHATEDGVTVFAD
>NZ_CP049838.1|WP_171399322.1|6542447_6543032_+|suppressor-of-fused-domain-protein
MVDVLPLVEARLRSALGEPDARAAVTFLGTDRLEVLRFHEGDVVRYATLGMSAQPMSDPTAMLADPVEGPRAELVLSVRPGASDTDKVLRPLAVLAASPQVEGVVVAPGSSLDVGEPLWPGAPFTSVLVAEPGGLVEDLDLDEPLDPVRFLPLLPMTPNEAAWKRVHGAQALQERWLTSGTDLRDPSRKSVPLD
>NZ_CP049838.1|WP_171399321.1|6540825_6541956_-|magnesium-and-cobalt-transport-protein-CorA
MSMIRDLRAVVRPARPSLRKGGGRMDTGAYDTTRDPATPSAVVDCAVYRDGSRVAYPQPPTPQEAMRQVRRDGGFVWIGLHEPTEAEFAGIASEFGLHPLAVEDAVQAHQRPKLERYDDSLFTVFKTIHYIEHDRLTANSEVVETGEVMCFTGKDFFITVRHGGQGSLRALRHRLQDDPELLAKGPSAVLHAIADHVVDGYIAVADAVQDDIDEVETEVFSPGRKGTPRGTDAGRIYQLKREVLEFKRAVSPLLRPMQLLSERPMRLVDPDIQKYFRDVADHLARVQEQVIGFDELLNSILQANLAQASVAQNEDMRKITSWAAIIAVPTMVCGVYGMNFDYMPELHSKFGYPVVMSAMVALCIGIHRTLKRNGWL
>NZ_CP049838.1|WP_171399320.1|6540273_6540792_-|hypothetical-protein
MTRELLLDQALVEEATKKSGLVWVQGAGEPAARALWHVWHEGAVCLVGDGPGEQPLAGLTEGGSAEVTVRSKDKGGRLVSWTAKVVSLAPGSQAWQAAVAELKGKRLNAPDGEAMTERWARECRVLRLEPTGATLPLPDGDLAARPVPSPATTREPAPAGLPKLLLRKRRRA
>NZ_CP049838.1|WP_171399329.1|6552616_6553354_+|tRNA-2-methylthio-N6-isopentenyl-adenosine(37)-hydroxylase-MiaE-like-protein
MRFMTTSDKPENTATGIAAQDWATASADPQYRAAVVDLLGALAYGELAAFERLAEDAKLAPTLEDKAELAKMASAEFHHFERLRNRLTEIGEEPTLAMEPFVAALDGFHRQTAPSDWLEGLVKAYVGDSIASDFYREVAVRLDTDSRALVLAVLDDTGHAGFAVDRVRGAIDADPRVGGRLALWARRLMGEALSQSQRVVADRDALSTMLVGGVADGFDLAEVGRMFSRITEAHTKRMAALGLAA
>NZ_CP049838.1|WP_171399330.1|6553385_6553655_-|hypothetical-protein
MILEALGSAVLGLVLAWAAIHRFSHRLPLRTLVFATGVAGALFGDFVTHSALGPGTALASLLGAAIVSAASLSLLLRPAGRLRRRSAPA
>NZ_CP049838.1|WP_020130831.1|6553880_6554108_-|DUF3107-domain-containing-protein
MEVKIGVLHAPREIVLESGQTPEEVERVVAEALAGKSQLLSLVDQHGRKVLVPADRLAYVELGEPAPRKVGFGAL
>NZ_CP049838.1|WP_020130830.1|6554254_6554896_-|TetR/AcrR-family-transcriptional-regulator
MTAIEQTEAARPRGTRLPRRARRNQLLGAAQEVFVAQGYHSAAMDDIAERAGVSKPVLYQHFPGKLDLYLALLDQHCESLIQAVRGALASTTDNKQRVRATMDAYFAYVEDDGGAFRLVFESDLTNEPAVRERVDKVTTECAEAICEVIAEDTGLSRAESMLLASGLGGLAQVVARSWLHSDRSVPRDQAVQLLASLAWRGIAGFPLHGTDQH
>NZ_CP049838.1|WP_171399331.1|6555076_6555295_-|hypothetical-protein
MAVDPTDPETFEEDDDFGEIDVEAPENDAAEQYKDVTPERDDSLEDVDPTRANEADLVEQARVVSLDEDDYR
>NZ_CP049838.1|WP_171399332.1|6555536_6556514_+|alpha/beta-hydrolase
MSSTELPSVPPTSVLPKAIAVRVAEGERLRSVGLPGVTLTVRSRPPAREGLEPALYVHGLGGSSQNWSALMALLDGVVASEAVDLPGFGDSPPPDDGNYSITAHARAVIRYLDAVDRGPVHLFGNSLGGAVSTRVAAVRPDLVRTLTLVSPALPELRVQRTAVPTGLVGLPGVAALFTRFTREWTAEQRVRGVTALCYGDPGRVSPDAFRHAVEELERRLQLPYFWDALTRSTRGLLSAYTLGGQHGLWRQAERVLAPTLLVYGGRDQLVGFRMAQRAARTFRDSRLLTLPDAGHVAMMEYPETVATAFRELLADTATATETSGG
>NZ_CP049838.1|WP_171399333.1|6556821_6557916_+|DUF3152-domain-containing-protein
MIPRQRPMPQDGPRQGPRQGSRQGPRQEYLDAFGEDDEDVFTRARTPSAAIRVREQDPYSAATDRETAFRTTTPAVVDGDDDAPPASEPVTAQGAKGRAFTGIAAAAVTTVLAVVVAGQVATGRDDDSVRSQSASGQTREAVDDAARGGDRPSPSVSGAPGGAATLTYAQRMDTKYALSATLKGSGKFDAVAGVDKAPGKGQKYTYRVDVEQGLGLDGELFAQAVQNTLNDARSWAHDGARTFERIQSGEADFVITLASPGTTAVWCAKSGLDTTEDNVSCDSASTERVMINAYRWAQGSETFGDKMYAYRQMLINHEVGHRLGYSHVTCDKDGELAPVMQQQTKFLDHDGIHCLPNAWPYPGS
>NZ_CP049838.1|WP_171399334.1|6558269_6559988_+|ABC-transporter-substrate-binding-protein
MRQPSLIARRVAAASVSLVVAAGAAACGPEDNDAKASGGDSAPHQGGTLTILNRNPQQDFDPARLYTSGGGKVPTLVFRTLTTRNRENGAPGTDVVPDLATDTGRPNKDATEWTYTLKEGLKYEDGTAITSADIKYGIERSFAPELSGGAPYLRDWLVGAADYQGPYKDSKGLAAIETPDSRTIVFHLNKPEGEFPYLATQTQFAPVPKAKDTGTKYEEHPVSSGPYKVVKNENDGERLTLERNTYWSAKTDAERKAYPDKIDVRSGLDSSVINQRLSASQGADATAITTDTNLGPAELAKVSGDKELAARVGTGHFGYTNYIAFNPNVKPFDDIRVRQAISYAIDRSSVVNAAGGSSLAEAATTYLPNQKSFGYEPYDLFPAGKTGDAAKAKELLKEAGHPNGLTITLTHSNSQDFETSPEIATAIQDALKKAGITVKLQGLEDNDYSDTIHDVKTEPGFFLAHWGADWPSGGPFLAPIFDGRQIVKDGANFNTGFLNDKSVNAEIDAINKLTDLDAAAKRWGALDKKIGEQALTVPLFHPVYKRLYGEDIRNIVISDWDGVLDPSQVAVK
>NZ_CP049838.1|WP_171402228.1|6560031_6561042_+|ABC-transporter-permease
MAAQAPGTDPASVPGASGARQFWRRLRAQRAALVAAVVVALLVLVALAAPLLTAIEGQDPTSYHPSLIDSARGGVPVGQLGGIGGDHWLGVEPQTGRDLFARLVHGARVSLGVALAATVIQVAIGVTLGIAAALGNRWVDQLLSRITDIFVALPLMIMSLALLAIVPASFPRPILVTLVIGLLSWGNVAKVVRAQTLTLKGLDYVSAARLSGWGTWRIARRELLPGLAAPVITYAALLVPQNISVEAALSFLGVGVKPPTPSWGQMLTAADVWYQAAPQYLLLPAGALFVTVLALTVLGDGVRTALDPRAASRLRVGTGRRREHRADTAVEKETSS
>NZ_CP049838.1|WP_171399335.1|6561038_6562046_+|ABC-transporter-permease
MSGFGGFGGFVLRRGIGTILTLFAISVIVYVVFYVTPGDVAQITCGPRCSPAQVHQVAEQLRLDEPLYVRYWHFLEGLVVGQDYSTGTSVEHCSAPCLGLSYQSDQQVTQLILTKLPVSLSLVFGAMVVWLILGVGTGVLSAWRRGRLTERVLTAVTLAGTATPVFVIGLILMIVVCGELQLLPFPQYVNLTDDPEQWAWNLLLPWLSLALIEAASFARLTRSSMLETLAEDHIRTFRAYGVGERSIIGRHALRGAFAPVIALNANNFGSAVGGAVLTETLFGLPGIGQELVHAVNVVDLPVVVGMVLVIGFFVVLANAVADVLYAVADRRVVLA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP049838_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049838_18

7038379-7038485

Orphan

Consensus_repeat	Method
GCGTACGGCTACCAGCAGCAGGCGGACCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049838_18

>merge|NZ_CP049838|18|7038379-7038485|CRISPRCasFinder
GCGTACGGCTACCAGCAGCAGGCGGACCCCTACGGCGGCTACCAGCAGCAACCGCAGCAGGGCTACGGCCAGCAGGACGCGTACGGCTACCAGCAGCAGGCCGACCC

>NZ_CP049838|18|12|7038379-7038485|CRISPRCasFinder
GCGTACGGCTACCAGCAGCAGGCGGACCC	CTACGGCGGCTACCAGCAGCAACCGCAGCAGGGCTACGGCCAGCAGGAC
GCGTACGGCTACCAGCAGCAGGCCGACCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049838.1\|WP_013000438.1\|7026742_7026928_-\|50S-ribosomal-protein-L28	unknown	unknown	gnl\|CDD\|234736
NZ_CP049838.1\|WP_171399651.1\|7041413_7041815_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP049838.1\|WP_007493396.1\|7039480_7039654_+\|50S-ribosomal-protein-L32	unknown	unknown	gnl\|CDD\|237038
NZ_CP049838.1\|WP_020128723.1\|7044548_7044752_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171399653.1\|7042555_7043689_-\|CAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|349398
NZ_CP049838.1\|WP_171399640.1\|7022196_7023402_-\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|169028
NZ_CP049838.1\|WP_171402257.1\|7038824_7039478_+\|DUF177-domain-containing-protein	unknown	unknown	gnl\|CDD\|376863
NZ_CP049838.1\|WP_171399649.1\|7039673_7040498_+\|ribonuclease-III	unknown	unknown	gnl\|CDD\|234633
NZ_CP049838.1\|WP_171399655.1\|7045027_7048585_+\|chromosome-segregation-protein-SMC	unknown	unknown	gnl\|CDD\|274008
NZ_CP049838.1\|WP_171399652.1\|7041921_7042509_+\|flavodoxin-family-protein	unknown	unknown	gnl\|CDD\|223728
NZ_CP049838.1\|WP_171399646.1\|7036397_7036982_+\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	unknown	unknown	gnl\|CDD\|367574
NZ_CP049838.1\|WP_171399647.1\|7036978_7037488_+\|pantetheine-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|234674
NZ_CP049838.1\|WP_171399645.1\|7034009_7036244_+\|ATP-dependent-DNA-helicase-RecG	unknown	unknown	gnl\|CDD\|236794
NZ_CP049838.1\|WP_171399643.1\|7028992_7031986_-\|tetratricopeptide-repeat-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171399641.1\|7023492_7026549_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|226418
NZ_CP049838.1\|WP_171399642.1\|7027206_7028934_+\|DAK2-domain-containing-protein	unknown	unknown	gnl\|CDD\|274671
NZ_CP049838.1\|WP_171399650.1\|7040580_7041441_+\|bifunctional-DNA-formamidopyrimidine-glycosylase/DNA-(apurinic-or-apyrimidinic-site)-lyase	unknown	unknown	gnl\|CDD\|234899
NZ_CP049838.1\|WP_171399644.1\|7031985_7033842_-\|HSP90-family-protein	unknown	unknown	gnl\|CDD\|237603
NZ_CP049838.1\|WP_171399654.1\|7043887_7044169_+\|acylphosphatase	unknown	unknown	gnl\|CDD\|237712
NZ_CP049838.1\|WP_171399639.1\|7021406_7022222_+\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|180561

Protein	Function_ID	Function_description	E-value
NZ_CP049838.1\|WP_013000438.1\|7026742_7026928_-\|50S-ribosomal-protein-L28	gnl\|CDD\|234736	PRK00359, rpmB, 50S ribosomal protein L28; Reviewed.	2.84054e-23
NZ_CP049838.1\|WP_171399651.1\|7041413_7041815_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	3.15945e-35
NZ_CP049838.1\|WP_007493396.1\|7039480_7039654_+\|50S-ribosomal-protein-L32	gnl\|CDD\|237038	PRK12286, rpmF, 50S ribosomal protein L32; Reviewed.	1.69982e-26
NZ_CP049838.1\|WP_171399653.1\|7042555_7043689_-\|CAP-domain-containing-protein	gnl\|CDD\|349398	cd05379, CAP_bacterial, Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins. Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.	1.63138e-41
NZ_CP049838.1\|WP_171399640.1\|7022196_7023402_-\|FAD-dependent-monooxygenase	gnl\|CDD\|169028	PRK07588, PRK07588, FAD-binding domain.	8.59817e-98
NZ_CP049838.1\|WP_171402257.1\|7038824_7039478_+\|DUF177-domain-containing-protein	gnl\|CDD\|376863	pfam02620, DUF177, Uncharacterized ACR, COG1399. This family is nearly universally conserved in bacteria and plants except the Chlorophyceae algae. Thus far, mutantional analysis in bacteria have not established a function. In contrast, mutants have embryo lethal phenotypes in maize and Arabidopsis. In maize, the mutant embryos arrest at an early transition stage.It has been suggested that family members specifically affect 23S rRNA accumulation in plastids as well as bacteria.	8.30362e-27
NZ_CP049838.1\|WP_171399649.1\|7039673_7040498_+\|ribonuclease-III	gnl\|CDD\|234633	PRK00102, rnc, ribonuclease III; Reviewed.	2.26712e-118
NZ_CP049838.1\|WP_171399655.1\|7045027_7048585_+\|chromosome-segregation-protein-SMC	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0
NZ_CP049838.1\|WP_171399646.1\|7036397_7036982_+\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	gnl\|CDD\|367574	pfam03602, Cons_hypoth95, Conserved hypothetical protein 95.	1.29791e-66
NZ_CP049838.1\|WP_171399647.1\|7036978_7037488_+\|pantetheine-phosphate-adenylyltransferase	gnl\|CDD\|234674	PRK00168, coaD, phosphopantetheine adenylyltransferase; Provisional.	3.47894e-100
NZ_CP049838.1\|WP_171399645.1\|7034009_7036244_+\|ATP-dependent-DNA-helicase-RecG	gnl\|CDD\|236794	PRK10917, PRK10917, ATP-dependent DNA helicase RecG; Provisional.	0
NZ_CP049838.1\|WP_171399652.1\|7041921_7042509_+\|flavodoxin-family-protein	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	1.99878e-32
NZ_CP049838.1\|WP_171399641.1\|7023492_7026549_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|226418	COG3903, COG3903, Predicted ATPase [General function prediction only].	6.0179e-50
NZ_CP049838.1\|WP_171399642.1\|7027206_7028934_+\|DAK2-domain-containing-protein	gnl\|CDD\|274671	TIGR03599, YloV, DAK2 domain fusion protein YloV. This model describes a protein family that contains an N-terminal DAK2 domain (pfam02734), so named because of similarity to the dihydroxyacetone kinase family family. The GTP-binding protein CgtA (a member of the obg family) is a bacterial GTPase associated with ribosome biogenesis, and it has a characteristic extension (TIGR03595) in certain lineages. This protein family described here was found, by the method of partial phylognetic profiling, to have a phylogenetic distribution strongly correlated to that of TIGR03595. This correlation implies some form of functional coupling.	2.19277e-140
NZ_CP049838.1\|WP_171399650.1\|7040580_7041441_+\|bifunctional-DNA-formamidopyrimidine-glycosylase/DNA-(apurinic-or-apyrimidinic-site)-lyase	gnl\|CDD\|234899	PRK01103, PRK01103, bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase.	2.62586e-145
NZ_CP049838.1\|WP_171399644.1\|7031985_7033842_-\|HSP90-family-protein	gnl\|CDD\|237603	PRK14083, PRK14083, HSP90 family protein; Provisional.	0
NZ_CP049838.1\|WP_171399654.1\|7043887_7044169_+\|acylphosphatase	gnl\|CDD\|237712	PRK14422, PRK14422, acylphosphatase; Provisional.	1.72898e-50
NZ_CP049838.1\|WP_171399639.1\|7021406_7022222_+\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl\|CDD\|180561	PRK06427, PRK06427, bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed.	3.7612e-123

>NZ_CP049838.1|WP_171399647.1|7036978_7037488_+|pantetheine-phosphate-adenylyltransferase
MTGLESEGPQVRRAVCPGSFDPITNGHLDIISRASRLYDEVYVAVMINKAKKGLFEIDERIDLIRQVTAEYGNVRVEAFHGLLVDFCKQRDIPAIVKGLRAVSDFDYELQMAQMNNGLSGVETLFVPTNPTYSFLSSSLVKEVATWGGDVSHLVPPLVLEALGERLRKD
>NZ_CP049838.1|WP_171399646.1|7036397_7036982_+|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD
MTRVIAGAAGGRRLAVPPGTGTRPTSDRAREGLFSTWQSLLGGPLGGERVLDLYAGSGAVGLEALSRGAGHTLLVEADARAARTVRENVKALGLPGAEVRAGKAQQIIQTPPADPYDLVFLDPPYAVSNDDLREILLTLRSGGWLAADALVTVERSTRGGEFPWPDGFEALRARRYGEGTFWYGRAASTCEDAR
>NZ_CP049838.1|WP_171399645.1|7034009_7036244_+|ATP-dependent-DNA-helicase-RecG
MDLVPALKEPLEQPLKSVLGPATAKVMAEHLGLHTVGDLLHHYPRRYEERGQLTHLADLPMDEHVTVVAQVADARLHSFASAKAPRGKGQRLEVTITDGSGRLQLVFFGSGVHKPHKELLPGTRAMFSGKVSVFNRRLQLAHPAYELLRADTDESVETWAGALIPLYPATAKLESWKIGKAIQTVLPTAQEALDPLPDSLRDGRGLVSLPEALLKIHRPHTKADIADARARLKWDEAFVLQVALARRRHADAQLPAVPRVPAADGLLTSFDARLPFTLTEGQQKVSKEIFDDLATDHPMHRLLQGEVGSGKTLVALRAMLAVVDAGGQAAMLAPTEVLAQQHHRSVVEMMGELAEGGMLGGSERATKVVVLTGSMGTAARRQALLDLVTGEAGIVIGTHALIEDKVRFHDLGLVVVDEQHRFGVEQRDALRSKGKQPPHLLVMTATPIPRTVAMTVFGDLETSVLDQLPAGRSPIASHVVPAADKPHFLARAWERVREEVGNGHQAYVVCPRIGDDADEAADAKKAGRTKKKSPEDEAEKRPPLAVLDIAEQLAKGPLHGLGVEVLHGRMPPDDKDAVMRRFAAGDTDVLVATTVIEVGVNVPNATAMVIMDADRFGVSQLHQLRGRVGRGSAPGLCLLVSEMPEASAARRRLDAVAATLDGFELSRIDLEQRREGDVLGQAQSGARSSLRVLAVIEDEEVIAEAREEAARLVAADPELETLPGLRTALDALLDEEREQYLDKG
>NZ_CP049838.1|WP_171399644.1|7031985_7033842_-|HSP90-family-protein
MDSQTSQSSQASQQPHTFQVDLRGLVDLLSHHLYSSPKVYLRELLQNAVDAITARRAEEPDAPARVRLFAADGGLRVEDSGVGLTEADVHDLLATIGRSSKRAEGLQEVRSDFLGQFGIGLLACFVVAERIRVVSRSARTPDAPPVEWTARDDGSYTVRTLPHEERPEPGTTVHLVARAGAGEWLTEPRVLALARDFGSLLPYDVRVGDEAVTDLPAPWNRSYASPANRRVALARHCHELFGFTPLDSVELDLPVAGVRGVAYVLPSAVSPAQRAGHRVHLKGMLLTERGEQLLPDWAFFVRCVLDTDSLRPTASRESLYEDETLAAVREALGERIRSWLTGLAAGDPQRLAAFLEVHHLGVKSLARHDEEMLRTMLPWLPFETTDGRLSLEEFAQRHPVVHFTRTVEEYRQVAPIASAQGIGVVNGGYTYDSELVEALPSVRPGTVVAELDADTVTAHLDTVAAADELALAGFLAAARAKLDPLGCDVVLRAFLPLSVPALHLDDRGARHEQARAQAEAQADDLWAGILGSLRGSAPRARLVLNHLNPLIRRISSLNDPELIGTATESLYGQALLMAQRPLRPADSALLNRAFIGLLEWATHGESAHGEPTEEQGGH
>NZ_CP049838.1|WP_171399643.1|7028992_7031986_-|tetratricopeptide-repeat-protein
MSEITDFDSLRRAMAENGEQPEGPARNARAEQLLLEAERLDIPLAVIEALGHQLKVYNYSSEKAKMFVPFARLLRMWDERPEDFDEYETHSLHWVFKWMSAGMLDQPHVPLASVEKWLGEMEHRYRLAGHSARAVRSAEFSVAAHVGDVERAERAFTAWLAADRDTMADCHACELHGQGWWQAERGRDAEALAVWAPVLEGEYTCAHEPHTVLASSLLPLLRLSRVEEARAHHLRGFRLVRSMESMRGAYADHVEFCALTGNEARGLELLAERPAYFTDEGHPHSKLEFLSVVVLLMERLSELGLAGQRVPGPAGREWTAVELAGHARAEALALAARFDERNGTSYVSGRARARMAQRPLVERLPLGVRAARPAAAAAAPGATAPAPAAVQEAVEPDLAVLLAEAQRLSDTLQPHAVEAWARVARLAEEVEGVELEARDRAEIADHEAIGLGPEGAEAFEHAAELYAQAGDPGEALAARARAAYVRALAGEIDEALAAVAEPYDRVLALYAEGDTEVPQAAGVLMGRARILMRRVHEAEGEVVDEAVLAEAEAAVRELLALVDGRAGNDVRLAARVAEGHAMLAELATHSGNPEAGAELFARAAAEFIETGLPWFAVEYEARLAGLAHQLGDMREAERALRAALEHGGPYLEAVGRAQLHLQLAEVVGGRGEAEEAAEHALEAAHWADEAGAGPTLGAWARHQLGGFLVRQGRWAEAAEVLESALAELTAETHGDGAVVQTQWWLGDCLSELGEHRDAAERRLQAAEIARHWPEQHDHATLAHLAAESLGQAGLRTEADQAYARAGELWRGLGNVHGLVRSLRARAWLALRTEDGTDAARDLMTSAVEECADAFDAADDDEARLRLVAELGHTHRQFGDLLARSAAEDADDDSIRATLDEALSQMSEAVAVFVALGEDAVHARTGAELAAGWLETDLGRPVAAAARARAVLRAYADAEDDADTAADLGGEEAEDETARARRAEAEQLLHATEEQKDR
>NZ_CP049838.1|WP_171399642.1|7027206_7028934_+|DAK2-domain-containing-protein
MAQVPQTFFDALAVRTWCGLALTALGRAREEIDAINVYPVADGDTGTNLYLTVESATTAVEAVFAGYAAGSGAGSAPAGKPSLADAARAMAHGALIGARGNSGTILAQLLRGMAQVLTAEGETPHTDGDGLRLALRHAADSARQAVAHPVEGTVLSVASAAAEAAEGAEGDCGTVARAAYRGACAALAATPGQLAVLEHAGVVDAGGRGLVAVLAALVETFTGEVPELSGAVSAAAAAAAAHGRVEAVHMADCADDGPDGAGGEDGEGGPAFEVIYLLEAEDTAVARLRQRLDALGDSLVVVGGDGLWNVHVHVDDAGAAVEAGVEAGRPYRIRITHFGADDAHTRGGERPPRERVQRAVVAVVPGEGLAGLYTEAGATTVLARPGEPPASGELVEAVRRAHAREVVLLPNDADLRHTAAAAAEQARTEGIRVALIPTRSAVQGIAALAVHEPDRRFDEDVVSMTSAAGATRYAEVTVAERQSWTMAGICQAGDVLGLIDGDVAVIGSDVTAAAETVLNRMLAAGGELVTLVLGDEAPEGVAEHLEARVREAYLAVDTVVYRGGRQGALVLIGVE
>NZ_CP049838.1|WP_013000438.1|7026742_7026928_-|50S-ribosomal-protein-L28
MAANCDVCGKGPSFGNNISHSHRRTSRRWNPNIQRVRTVVGGTPKRVNACTSCIKAGKVSR
>NZ_CP049838.1|WP_171399641.1|7023492_7026549_-|tetratricopeptide-repeat-protein
MRFGILGTLDLRADDGTPVDPGGPRPRALLSLLLLEAGRGVSLARLTDGLYGTEPPSGAGNALQSQVSRLRRRLAPHAEIEATPAGYRLAVPPDAVDLHRFERLTGQGRAALAAGDHATAATLLREALALWRGPALPDLPDAHAERARLDALRLSAVQDRVDADLLLGGGPDLVPELRGLLTAHPLSERLYGQLMRALHADGRPAEALTVFEEARHALADQLGADPSPELAALHLELLRGGGPGRSSVPVQLTRFIGRESELACIAEALSEARLVTLTGPGGAGKTRLAIEAARARTEAPHLPSSSATPEDVCFVELAPLADGTRIPYAVLAALGVREGFRTPAGDGAGRLSAVLEDRELLLVLDNCEHLVEDAARLSALLLASCPGVRVLATSRESLGITGEVLVPVPPLPPDPALRLFLDRARAVRPGFEGHARVPAVCAALDGLPLAIELAAARLRTLTPDELADRLDDRFRLLSRGDRSKAPRHRTLRAVVEWSWDLLDEEERELARRFTVFSGGATLDAVETVCGLPYPEDLLASLVEKSFLEVTESPATAESRYRMLETIRVFAAEGCAAEPALRDAHARYFLRLAERAEPYLRGRDQLPWLARLDAEHDNLDAAMGLLTATDPAAALRLMATLTWFRRLRGLHGEQLPQARALLAAVGDEPPGEPTEEYALCLMNTVAGRGDDPGEAARIASAVAVMRSLDRPLRLPFTVIVWSLTGGPLLAADEHVRVQVGEEPWGHALLDLGLAYQELYSGRATAAEASFARSLEGFRATGDRWGMANCLDPLALFADGRGDHTRALELLDEGLAYVRELEAPEEIADLLRSRAAVLLHRGAAEEAAALFTRSAALARTAGVPDKVAGARRGLGDVARLSGDTAHARVHYESGLELCTATWFSTSETVRLLVGLGRTAAAEGQVETAREWFEQARAPALESFDVLALADLADALASVAARPERAAELLGAAAGLRGTVLLGDPDVVRTVNDVRGRLSPQAYETAFALGRSRRSAAVGEP
>NZ_CP049838.1|WP_171399640.1|7022196_7023402_-|FAD-dependent-monooxygenase
MTKTRSSLSHLSVLISGASVAGPALALHLVRYGARVTVVERSPDLRAGGFAVDFRGHVHREILTSMGIWDEIHARQTHMGRQIVVAEDGSPRVDLPAEMMSGDVEILRGDLAQIMYERTRDHVDYVFGDSIATLTDTAAGVDVTFEENAPRRFDLVIGADGLHSNTRRLVFGDESRYLRFFDHYVAAFEVPNDLGLDRTGRLYSEPGRAIALGNYDGDPDRAGALLVFRSEQLAYDRQDIAAQKRILAERFAGMGWEAPRVLEALTDADRLYFDAIAQIHVDRLAEGRVALLGDAGYGATMGGMGTGAAIVGAYVLAGELALAGGDHRRAFAEYESRIRSFAKGCQKISGNAGPFFAPPTERRIRSRDRMYRLLGSRLLAGVFKRLTEKAATDIRLRPYPG
>NZ_CP049838.1|WP_171399639.1|7021406_7022222_+|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MSALGTPPRVLTVAGSDSGGGAGIQADLKTMLALGVHGMSVVTAVTAQNSQGVQGAWELPVEAVRAQYRSVVDDIGVQAVKTGMLASAELVETVAELLAGTGAPVVVDPVGVSKHGDPLLAASALDSVRTKLLPVATVATPNLDEVAQLTGVRVESEEQLRDAAAAVLAYGPRWALIKGGHLPGAAVDLLTDGREEHWLRAPRYDNRHTHGTGCTLASAIAAQLAKGSPVPEAVAAAKRYVTGAIAAGFALGAGIGPVDHGWDLSRGTAGA
>NZ_CP049838.1|WP_171402257.1|7038824_7039478_+|DUF177-domain-containing-protein
MALNARLDHRKPLVFDTHELGRRPGALQRLTREFDAPQDLGIQGVIGVPEGAPVELELRLESVMEGVLVTGTARAQAEGECVRCLEPLELELEADFQEMFSYPDADDRGRPKAEPVDDAEEDEDRLFIEDGLFDLEPVLRDAVVLALPMQPVCQDDCLGLCSECGARLTDDPDHHHDATDIRWAALQGLAGSLEDGEKDEMSGEAPRSARANEKQEK
>NZ_CP049838.1|WP_007493396.1|7039480_7039654_+|50S-ribosomal-protein-L32
MAVPKRKMSRSNTRHRRSQWKAAVPTLVACERCHEPKLQHIACPSCGTYNKRQVLEV
>NZ_CP049838.1|WP_171399649.1|7039673_7040498_+|ribonuclease-III
MSDAKADTTAKKKAENTASSHTLLEGRLGYQLESALLVRALTHRSFAYENGGLPTNERLEFLGDSVLGLVVTDTLYRTHPDLPEGQLAKLRAAVVNSRALAEVGRGLDLGSFIRLGRGEEGTGGRDKASILADTLEAVIGAVYLDQGLDAASELVHRLFDPLIEKSSNLGAGLDWKTSLQELTATEGLGVPEYLVTETGPDHEKTFTAAARVGGVSYGTGTGRSKKEAEQQAAESAWRSIRAAADERAKAAKAVEVVEAVQAADGSPDPESASA
>NZ_CP049838.1|WP_171399650.1|7040580_7041441_+|bifunctional-DNA-formamidopyrimidine-glycosylase/DNA-(apurinic-or-apyrimidinic-site)-lyase
MPELPEVEVVRRGLERWVAHRTVAEAEVLHPRAVRRHIAGSDDFAHRLKGHRIGTPGRRGKYLWLPLTDTHQAVLAHLGMSGQLLVQPHEAPDEKHLRVRVRFADAVNTELRFVDQRTFGGLSLHDTTSDGLPDVIAHIARDPLDPLFDDEAFHQALRRKRTTIKRALLDQSLISGVGNIYADEALWRARLHYDRPTANFTRPRTLELLGHVRDVMNAALAVGGTSFDSLYVNVNGESGYFDRSLDAYGREGLPCRRCATPMVRRPWMNRSSYFCPKCQKVPRVPS
>NZ_CP049838.1|WP_171399651.1|7041413_7041815_-|helix-turn-helix-transcriptional-regulator
MDITQERAEDQDLPFNVFAKACPSRGTLEHVTGRWGGLTLGALYEGSLRFNELRRRVDGVSEKMLSQTLHALERDGLVHREAQPTNPPRVDYELTPLGREVAERLLSLIHCVEGRMGDVLAARERYDGTRGTF
>NZ_CP049838.1|WP_171399652.1|7041921_7042509_+|flavodoxin-family-protein
MSTPVIAVAYHSGYGHTAVLAEAVRAGAADAGAEVRLIKVDEITEEQWTLLDGSDAIVFGSPTYMGTASGAFHAFAEATSARWATQAWKDKLAAGFTNSGSKSGDKLHTLQFFQILAAQLGMHWVNLGLLPGWNSSTASEHDLNRLGVFLGAAAQTNVDEGPDAVHKADVATAEHLGRRVAETAKVFLAGRAQAA
>NZ_CP049838.1|WP_171399653.1|7042555_7043689_-|CAP-domain-containing-protein
MGRHRRSAAGSAATSRATGVTQTHGSHADSHTPQDPYADERPTMGIAPYLNPEAYADSVARSREYLYATGDEYAHADTAVFAMDGFRPDDGDLRPGSNRATAGRRRKRKVATPVKTGLLGVSAAVAIGTVAVATGVVPGLDNYQLGGGSGSGDKVQAADSPTNSASEQGGTSGSADTERGGTSTSRDAGRSTSPSASPTPSPSTSTASASPTETATKKPQATPSKEPKTTPSKSKTATKAPEKSESPVTVSAEAQAAAEVLKLVNEERAKVGCSAVSANSALSKLAEKFSDDMAARGFFDHTDPDGATPWDRAAKAGIADLGGENIARGQADAAAVMEAWMNSPGHKANILNCDFKTLGVGVHLGSGGPWWTQDFGY
>NZ_CP049838.1|WP_171399654.1|7043887_7044169_+|acylphosphatase
MNEDVRLVAWVRGRVQGVGFRWFTRAKALEIGGLSGFALNLADGRVQIVAEGAREGCEGLLGWLLGDDTPGRVDGVTEIWDTPRGGYDGFAIR
>NZ_CP049838.1|WP_020128723.1|7044548_7044752_+|hypothetical-protein
MAKALLGYVGGSDPRLLAEMRRLQQRVQDLESELGRIQAENDALTAAASHESLLESIDARQAEPALT
>NZ_CP049838.1|WP_171399655.1|7045027_7048585_+|chromosome-segregation-protein-SMC
MHLKALTLRGFKSFASATTLRFEPGITCVVGPNGSGKSNVVDALSWVMGEQGAKSLRGGKMEDVIFAGTTGRPPLGRAEVSLTIDNSDGALPIEYAEVTITRIMFRNGGSEYQINGDTCRLLDIQDLLSDSGIGREMHVIVGQGQLDSVLHADPMGRRAFIEEAAGVLKHRKRKEKALRKLDAMQANLARVQDLTDELRRQLKPLGRQAAVARRAAVIQADLRDARLRLLADDLVRLREALQTEVADEAALKERKEAAEQELRKALQREALLEDEVRRLAPRLQRAQQTWYELSQLAERVRGTISLADARVKSATSAPPEERRGRDPEDMEREAARVREQEAELEAALEAAQHALDDTVAHRADLERELAVEERRLKDVARAIADRREGLVRLNGQVNAARSRAASAQAEIDRLAAARDEAQERAVTAQEEYEELKAEVDGLDAGDQELGEQHETAKRRLVEAEAALTAAREAVTGAERRRAATQARHETLAMGLRRKDGTGALLGARDRLSGLLGPAAELLTVRQGYEVPLAAAFGAAADALAVTTPAAAAEAIRFLRKQDGGRAALLLSGAPDDVPQEPGETEGPRYAADLVQGPDDLLPAVRRLLRGIVVVSTLEDAEEVVYARPDLTAVTAEGDLLGAHFAHGGSAGAPSLLEVQASVDEAAAELEELAVRCEELTGAQHAAGERRKECAALVEEAGERRRAADREKSAVAQQLGRLAGQARGAAGEAERSTAAAARAQEALDRAVEEAEELAERLAVAEEMPVEEEPDTSARDRLAADGANARQTEMEARLQVRTHEERVKGLAGRADSLDRAARAEREARARAEQRRARLRHEAAVAEAVASGARGLLTHVEVSLGRAEAERVAADAAKARREQELAAARTAGRDLKAELDKLTDSVHRGEVLGAEKRMRIEQLETKALEELGVEPAGLVSEYGPHQPVPPSPPAEGEVLPEDPEDPRNQPRRFLRAEQEKRLRAAERAYQQLGKVNPLALEEFSALEERHKFLSEQLEDLKKTRADLLQVVKEVDERVEQVFTEAFRDTARQFEGVFSRLFPGGEGRLILTDPDNMLTTGVDVEARPPGKKVKRLSLLSGGERSLTAVAMLVSIFKARPSPFYVMDEVEAALDDTNLQRLIRIMQELQESSQLIVITHQKRTMEVADALYGVSMQGDGVSKVISQRLR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP049838_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049838_19

7945444-7945568

Orphan

Consensus_repeat	Method
GGACACCGCGCCCGTGGTGGACTCGACCCCCGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049838_19

>merge|NZ_CP049838|19|7945444-7945568|CRISPRCasFinder
GGAACCCGTGCCCGCGAAGGACACCGCGCCCGTGGTGGACTCGACCCCCGCGGAAGCCGCCCCGGTCGCCGACGCAGCTTCCACCGTGGCCCCCGCCGCGCCCGCGGCGGACACCGCGCCCGTGG

>NZ_CP049838|19|13|7945444-7945568|CRISPRCasFinder
GGAACCCGTGCCCGCGAAGGACACCGCGCCCGTGG	TGGACTCGACCCCCGCGGAAGCCGCCCCGGTCGCCGACGCAGCTTCCACCGTGGC
CCCCGCCGCGCCCGCGGCGGACACCGCGCCCGTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049838.1\|WP_171400313.1\|7936350_7937535_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP049838.1\|WP_171402312.1\|7951320_7951956_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|316044
NZ_CP049838.1\|WP_171400319.1\|7949360_7949936_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|340879
NZ_CP049838.1\|WP_171400325.1\|7956760_7958572_+\|gamma-glutamyltransferase	unknown	unknown	gnl\|CDD\|366419
NZ_CP049838.1\|WP_171400314.1\|7937605_7938622_-\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|275173
NZ_CP049838.1\|WP_171400324.1\|7955870_7956617_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171400321.1\|7951995_7952775_+\|exodeoxyribonuclease-III	unknown	unknown	gnl\|CDD\|197320
NZ_CP049838.1\|WP_171400323.1\|7953427_7954171_+\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP049838.1\|WP_171400312.1\|7935590_7936271_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP049838.1\|WP_171400318.1\|7947686_7948949_+\|sulfite-oxidase	unknown	unknown	gnl\|CDD\|239028
NZ_CP049838.1\|WP_171402311.1\|7942298_7945133_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223627
NZ_CP049838.1\|WP_171400322.1\|7952891_7953311_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171402310.1\|7938750_7939488_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NZ_CP049838.1\|WP_171400315.1\|7940313_7941462_+\|ROK-family-glucokinase	unknown	unknown	gnl\|CDD\|273246
NZ_CP049838.1\|WP_171400309.1\|7933344_7933731_-\|ribonuclease	unknown	unknown	gnl\|CDD\|238340
NZ_CP049838.1\|WP_171400311.1\|7934241_7935504_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP049838.1\|WP_171400320.1\|7949966_7951277_+\|4-carboxymuconolactone-decarboxylase	unknown	unknown	gnl\|CDD\|131480
NZ_CP049838.1\|WP_171402313.1\|7954219_7955773_-\|CocE/NonD-family-hydrolase	unknown	unknown	gnl\|CDD\|334820
NZ_CP049838.1\|WP_171400316.1\|7941573_7942170_+\|sugar-kinase	unknown	unknown	unknown
NZ_CP049838.1\|WP_171400310.1\|7933841_7934042_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP049838.1\|WP_171400313.1\|7936350_7937535_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	2.07606e-89
NZ_CP049838.1\|WP_171402312.1\|7951320_7951956_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|316044	pfam13483, Lactamase_B_3, Beta-lactamase superfamily domain. This family is part of the beta-lactamase superfamily and is related to pfam00753.	2.0232e-26
NZ_CP049838.1\|WP_171400325.1\|7956760_7958572_+\|gamma-glutamyltransferase	gnl\|CDD\|366419	pfam01019, G_glu_transpept, Gamma-glutamyltranspeptidase.	0
NZ_CP049838.1\|WP_171400314.1\|7937605_7938622_-\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|275173	TIGR04380, hypothetical_protein_HOLDEFILI_04020, inositol 2-dehydrogenase. All members of the seed alignment for this model are known or predicted inositol 2-dehydrogenase sequences co-clustered with other enzymes for catabolism of myo-inositol or closely related compounds. Inositol 2-dehydrogenase catalyzes the first step in inositol catabolism. Members of this family may vary somewhat in their ranges of acceptable substrates and some may act on analogs to myo-inositol rather than myo-inositol per se. [Energy metabolism, Sugars].	4.23011e-97
NZ_CP049838.1\|WP_171400321.1\|7951995_7952775_+\|exodeoxyribonuclease-III	gnl\|CDD\|197320	cd09086, ExoIII-like_AP-endo, Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases. This subfamily includes Escherichia coli ExoIII, Neisseria meningitides NExo,and related proteins. These are ExoIII family AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiencies. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity. For example, Neisseria meningitides Nape and NExo, and exonuclease III (ExoIII) and endonuclease IV (EndoIV) in Escherichia coli. NExo and ExoIII are found in this subfamily. NExo is the non-dominant AP endonuclease. It exhibits strong 3'-5' exonuclease and 3'-deoxyribose phosphodiesterase activities. Escherichia coli ExoIII is an active AP endonuclease, and in addition, it exhibits double strand (ds)-specific 3'-5' exonuclease, exonucleolytic RNase H, 3'-phosphomonoesterase and 3'-phosphodiesterase activities, all catalyzed by a single active site. Class II AP endonucleases have been classified into two families, designated ExoIII and EndoIV, based on their homology to the Escherichia coli enzymes ExoIII and endonuclease IV (EndoIV). This subfamily belongs to the ExoIII family; the EndoIV family belongs to a different superfamily.	2.26289e-113
NZ_CP049838.1\|WP_171400311.1\|7934241_7935504_+\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	7.05833e-32
NZ_CP049838.1\|WP_171400312.1\|7935590_7936271_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.33266e-66
NZ_CP049838.1\|WP_171400318.1\|7947686_7948949_+\|sulfite-oxidase	gnl\|CDD\|239028	cd02110, SO_family_Moco_dimer, Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). .	9.02797e-106
NZ_CP049838.1\|WP_171402311.1\|7942298_7945133_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|223627	COG0553, HepA, Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair].	7.19014e-117
NZ_CP049838.1\|WP_171402310.1\|7938750_7939488_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	1.66482e-64
NZ_CP049838.1\|WP_171400309.1\|7933344_7933731_-\|ribonuclease	gnl\|CDD\|238340	cd00607, RNase_Sa, RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate specific endoribonuclease which belongs to the superfamily of microbial ribonucleases. Typical of this sub-family, the enzyme hydrolyses the phosphodiester bonds of RNA at the 3' oxygen end of guanosine residues to yield oligonucleotides with the guanosine-2',3'-cyclophosphate at the 3' end and the hydroxyl group at the 5' end. The terminal guanosine-2,3'-cyclophosphate is hydrolysed by guanyl RNAses to give guanosine-3'-phosphate.	1.72892e-44
NZ_CP049838.1\|WP_171400319.1\|7949360_7949936_+\|hypothetical-protein	gnl\|CDD\|340879	cd17321, MFS_MMR_MDR_like, Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.29879e-06
NZ_CP049838.1\|WP_171400320.1\|7949966_7951277_+\|4-carboxymuconolactone-decarboxylase	gnl\|CDD\|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	1.52564e-73
NZ_CP049838.1\|WP_171402313.1\|7954219_7955773_-\|CocE/NonD-family-hydrolase	gnl\|CDD\|334820	pfam02129, Peptidase_S15, X-Pro dipeptidyl-peptidase (S15 family).	9.52588e-38
NZ_CP049838.1\|WP_171400323.1\|7953427_7954171_+\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	4.75368e-152
NZ_CP049838.1\|WP_171400315.1\|7940313_7941462_+\|ROK-family-glucokinase	gnl\|CDD\|273246	TIGR00744, Glucokinase_Glucose_kinase., ROK family protein (putative glucokinase). This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General].	4.79216e-89

>NZ_CP049838.1|WP_171402311.1|7942298_7945133_+|DEAD/DEAH-box-helicase
MADGTAAAEPGSVSVRLAAVFLPAPLPREGRVAFWDPAEGPLPTTADVEHTELTVVRRHGSAIRRDQTPALSLPLDKALPLLVRARRDPAAHPATACWGAAALHALRLTARGRLLPGLTPSGHDAWRAGPLDPEDIAHLRAVAAALPHEGHAVPLPGAGPLRLPRPEALMRSFLDAVADTLPRTPAAPYACGKPFADRRPQRLPGAHDWAAEVAAGMDAGVRISLRLDLSAYDMFDRLDDGERTRRAGAAIVQVHSLADPTLMTDAAALWAGEADAAFGARARVDAALAVRRAARVWPPLARLAEQDAPDVLALSEDELSDLLGVAATRLAATGVAVHWPRDLAQDLSAAAVVRTAPGSATDGTGFFESEELLQFRWQLALGGDPLSEAEMDTLAEAHRPVVRLRDQWVLVDPALVRKARKRELGLLDPVDALSVALSGTAEVDGESVEAVPVGALAALRDRLTSGVHPADPPAGLHATLRDYQLRGLAWLDLMTSLGLGGCLADDMGLGKTITVIALHLKRARTEPTLVVCPASLMGNWQREINRFAPGVPVRRFHGPDRSLADLGGGFVLTTYGTMRSAAPTLAGQPWGMVVADEAQHVKNPYSATAKALRTIPTPARVALTGTPVENNLSELWALLDWTTPGLLGPLKSFRARHARAVENGEDDQAVERLARLVRPFLLRRKKSDPGIVPELPPKTETDHPVPLTREQAALYEAVVRESLLAIETADGIARRGLVLKLLGALKQICDHPALYLKEETASVGDALAARSGKLALLDELLDTLLAEDGSALVFTQYVGMARLITAHLTARAVPVDLLHGGTPIPERERMVDRFQAGATPVLVLSLKAAGTGLNLTRAGHVVHFDRWWNPAVEEQATDRAYRIGQTQPVQVHRLITEGTVEDRIAEMLQAKRALADAILGSGESALTELTDRELSDLVRLRREA
>NZ_CP049838.1|WP_171400316.1|7941573_7942170_+|sugar-kinase
MTASLPRQGAPPPDEPHRPPEDRRHVIRRRALTLLIIVLLIGVPAGYLVISANQSRDSGKDKEAKYSATGLTEGWPSKVQRRLYQVPIPHPSNQVAYYETNNWKTSRLYAQFQTTQAGLDEFLAGIGVSRGDLKKGDITISARDQEVTGWKFTGPGSRPGDDFGIVHEQKNPKPTLDVVVNTGNAIYPFVYVVSRTVP
>NZ_CP049838.1|WP_171400315.1|7940313_7941462_+|ROK-family-glucokinase
MSTYGNFTAPIGSRRAPALRTVGTRERRSHLTAPRVPTVGIDIGGTKVMAGVVDADGNILEKVRTETPDKSKSPKVVEDTIVELVLDLSDRHDVHAVGVGAAGWVDADRNRVLFAPHLSWRNEPLRDRLSSRLAVPVLVDNDANTAAWAEWRFGAGRGEDHLVMITLGTGIGGAILEDGQVKRGKYGVAGEFGHMQVVPGGHRCPCGNRGCWEQYSSGNALVREARELAAADSPVAYGIIEHVKGNIGDITGPMITELAREGDAMCIELLQDIGQWLGVGIANLAAALDPSCFVIGGGVSAADDLLISPARDAFKRQLTGRGYRPEARIVRAQLGPEAGMVGAADLARLVARRFRRAKRRRVERYERFERFTEAARRTQDTA
>NZ_CP049838.1|WP_171402310.1|7938750_7939488_+|GntR-family-transcriptional-regulator
MQLELRVDRSSPVPLYFQLAQQLEAAIEHGSLTPGSLLGNEIELAARLGLSRPTVRQAIQSLVDKGLLVRRRGVGTQVVHSQVKRPLELSSLYDDLEAAGQRPATTVLVNTVVPASAEVAAALAVAEGSDVHRVERLRLAHGEPMAYLCNHLPSGLLDLDTGQLQATGLYRLMRSAGITLHSARQSIGARAATTAEAERLAEEEGAPLLTMQRTTFDDTGRAVEFGDHIYRPTRYSFEFQLLVRP
>NZ_CP049838.1|WP_171400314.1|7937605_7938622_-|Gfo/Idh/MocA-family-oxidoreductase
MRIGVIGTGRIGTIHANTLSRHREVGSLILTDADHARAQELAHRLGETAAPGVDEIFRWGVDAVVITTATSAHAELIGRAARSGLPVFCEKPIALDLAGTLQAIAEVETAGTILHMGFQRRFDAGYTGAREAVLSGRLGRLHTVRALTSDQSAPPAAWLPVSGGIYRDALLHDFDCLRWVTGREVTEVYAAGSDAGPAMFREAGDVDTAAAVLTLDDGTLATATATRLNGAGYDVRMELAGELDQIVVGLDDRTPIASTEPTGPPAADKPWTGFLERFEPAYAAELNAFVDVVRGERANPCDGREALEALRIAEACEVSRRDRRAVWLEEIPVTSAAG
>NZ_CP049838.1|WP_171400313.1|7936350_7937535_+|cytochrome-P450
MTDVIDLGEFGDDFRRNPHPVYARLRERGPVHRVRLPVPDAHHVTWLVVGHEEARAALADPRPAKDSERIGVTFLDEQLIGKHLLTADPPRHTRLRALVSRAFTVRRVEELRPRIQRITDHLLDAMLPHGRADLVESLAHPLPLTVICELLGVPEVDRTAFRKLSGEAVAPTSSETEYDAFVRLGTYLTELIEDKRCAGPSGDLLDDLIRTTAQDGDRLSPAELRGMAFILLIAGHETTVNLITNAVHALLTHPDQLAALRADMTLLDGTVEEALRYEGPVENATYRFAAEPLEIAGTSVAQGEAVMIGLTAADRDPGRCPAPDDFDIRRDSRGHLAFGHGIHYCLGAPLARLEARTAIRTLLDRTPALALDGPPGDWLPGPLMRGMRSLPVRW
>NZ_CP049838.1|WP_171400312.1|7935590_7936271_+|response-regulator-transcription-factor
MTAIRLLLVDDDPLVRAGLAFMMGGADDIEIVGEAADGSEVEGLVERTRPDVVLMDIRMPTVDGLTATERLRGREDAPQVVVLTTFHADEQVLRALRAGAAGFVLKDTPPVEILDAVRRVAAGDPVLSPTVTRQLMDHAAGTAADTRRPHARVRLAALGEREREVAVAVGRGLSNADIAAELFMSVATVKAHVSRVLAKLGLNNRVQIALLAYDAGLLEEGADGPG
>NZ_CP049838.1|WP_171400311.1|7934241_7935504_+|sensor-histidine-kinase
MRADDNTAPAAPGFTGRRWLLPSAVVAELAPDAGHPGRPHRRTARDWIVDFLCFLVAVAVGLTVADSFPGERDLPEVVAAADQLLGALACAAVWLRRRWPLGLAIAMVPLGFLSTTSAGACTVALFTLAVHRPFRYVAWVGGAQVALIPLLAWARPDPTLAYLPSVAWSVLFTVTAIGWGMFVRSRRQLMVSLRDRARRAETEARLRAEQAQRLAREAIAREMHDVLAHRLTLLSVHAGALEFRPDAPREEVARAAGVIRESAHEALQDLREIIGVLRAAEPDDAGRPQPTLAALDTLVAESREAGMKVTLDQRVTDAGAVPASVGRTAYRIAQECLTNARKHAPGAEVAVTVVGGPGEGLDVTVRNPAPEGDVPPVPGSGQGLIGLTERATLTGGRLEHGTWGDGGFEVRAWLPWPATP
>NZ_CP049838.1|WP_171400310.1|7933841_7934042_-|hypothetical-protein
MKELLGVLGFLALVQGALGLLHEFTRWHVGLVQRLGLLDGYEVYASVALIVLAFALFAAAESRKPG
>NZ_CP049838.1|WP_171400309.1|7933344_7933731_-|ribonuclease
MRFPPRITRTVTSAAVLSALLVGGAVSATTAHAAVGSVCYTKLPSQAYDTLELIDAGGPFPYSQDGAVFQNREGVLPSQTTGYYHEYTVKTPGSSTRGARRIVTGKKSAEDYYTADHYVTFNLINYGC
>NZ_CP049838.1|WP_171400318.1|7947686_7948949_+|sulfite-oxidase
MPMSPTPESAYDRRRLHQWLAGEARADGVSRRDLLRLVAAAGLATAVAPAFSAPAAAATSPGIVKALPDDWFTVRGTNAETKFASLAGTGYHTPVDHFFVRNHTSTPVLDAADWTLTVHGDGLTHATPVEFTLDDLRKFPSVTRTAFVECAGNGRSFFTSQQGQTVTGTAWTLGAIGTARWRGVRLADVLRRAGLARDAVDVLPRGLDPDYVTADGTDLGRVRRPLPVSKALDDVLLAYEMNGEPLPYDHGFPVRVLVPNWIGIASIKWVGDIEVSAQPLYSPWNTDFYRLFGSAHPEGGSAPLTRQTVKSAWELPWDASLGAGAVHRLTGRSWSGAGAVVRVDVSTDGGTSWRRARLHDAPRRAGWVRWSTDWHPSAPGGYTLLARATDSTGRTQPETTVPNTQGYLFDAVVRHPVRAV
>NZ_CP049838.1|WP_171400319.1|7949360_7949936_+|hypothetical-protein
MGAAGFSLGVVTAGQLLYTTVEQGAYTTHLLPAALLVGTGIAIAHPAAVMLASAAASLDDQGTASGFLVTCQQAGGATGVAAVTAIRSVAPGTFWSGPYSLWGCFAFAAASLPGCLLLLPPGEDPRERCDDPGPAHRAPRGTNSLTPLGSPGRHPPWAVRHLRSSLRRWQDEFLFTGRRERTRPARFAPAT
>NZ_CP049838.1|WP_171400320.1|7949966_7951277_+|4-carboxymuconolactone-decarboxylase
MSETPPNTLQYRFDGPEDAPVLILGPSLGTTWHMWDRQVPELAQQWRIFRYDLPGHGGAPAYPVGSVSDLAGRLLATLDGLGVQRFGYAGCAFGGAVGVELALRHPERVASLALIAASPRFGTADEFRQRGVIVRTNGLDPIARSSPDRWFTSGFAAAQPAITEWAVQMVRTTDPGCYIAACEALASFDVRAEIGLVGVPTLVLVGSDDQVTGPAEARTLVAGIPDARLAVVPGASHLVPVEQPAAVTDLLVRHFSTAWQPAYDSGTGQTAVPGIPVRAVPIAPQQPPQPVAIAEIAPAPVLEPVQVMGRPDPYDAGLKVRREVLGDAHVDRALSQADDFSGEFQEFITRYAWGEIWDRPGLDRRSRSCVTLTALVAGGHLEELAFHIRAALRNGLTPDEIKEVLLQAAVYCGVPAANSAFKVAQQVIREETTPTE
>NZ_CP049838.1|WP_171402312.1|7951320_7951956_+|MBL-fold-metallo-hydrolase
MKLTKKSHACVRLEKDGRTLVLDPGGFSEADAAVGADAILVTHEHPDHFDEKRLRAALEADPAVELWTLRSVAEKLSAAFPGRVHTVGHGDTFTAAGFDVQVHGELHAVIHPDLPRVTNVGFLVDEGRVFHPGDALTVPEHPVETLLAPVQAPWNKISEVIEYIREVRPQRVYDIHDALLTDLARPIYDTHLGNLGGADHGRLAPGASAEV
>NZ_CP049838.1|WP_171400321.1|7951995_7952775_+|exodeoxyribonuclease-III
MRIATWNVNSITARLPRLLAWLESSGTDVLCLQEAKVAEAQFPLDQLRELGYEAAVHATGRWNGVAVISRVGLADVVKGLPGDPGYDGAPEPRAIAATCGPVRVWSVYVPNGREVDHPHYAYKLQWFEALKAAVAGDAAGSRPFAVMGDYNVAPTDDDVHDVAAFEGLTHVTPAERAALASLREAGLSDVVPRPLKYDHPFTYWDYRQLCFPKNRGMRIDLVYGNEPFAKAVKDAYVDREERKGKGASDHAPVVVDLEV
>NZ_CP049838.1|WP_171400322.1|7952891_7953311_+|hypothetical-protein
MNIPFLGNRSKKYRAAVLAEDPEGIAELLSECELLRSQAAREGIGLDDTAASLEALDQLPPRWRDDEETLPWFGHDAGLYLGTVVVRTVPGAVWVIWPGGEPVVRLASGREVDVVAAGRDWAATGTPELSQLYAEVAEN
>NZ_CP049838.1|WP_171400323.1|7953427_7954171_+|amino-acid-ABC-transporter-ATP-binding-protein
MAVDPLIELRDVNKYFGELHVLQDVNLTVGRGEVVVVIGPSGSGKSTLCRAINRLEPIHSGSITLDGQPLPEEGKALAKLRSEVGMVFQSFNLFAHKTVLQNISLGQVKVRRRKKHEADRRSRELLDRVGLADQADKFPAQLSGGQQQRVAIARALAMDPKALLFDEPTSALDPEMINEVLEVMQQLAQEGMTMVVVTHEMGFARSAANRVVFMADGRIVEDRTPEEFFTAPRSDRAKDFLSKILKH
>NZ_CP049838.1|WP_171402313.1|7954219_7955773_-|CocE/NonD-family-hydrolase
MALRTTAMGAVSATLVAGGVLGLTPAARAATGGVRYVDIAGDGGTVLKANVVTPAGADGTRRHPLIVLPTSWGFPQVEYLAQAQRLADSGYVVLSYNVRGFWQSGGEIDVAGPHDVADAAKVVDWALAHTPSDPENVGMAGVSYGAGISLLAAAHDPRVKAVASLSGWGDLIDSIYSGRTQHVQAAAALDTVGTVTGRRSAESQEVFSAFYSSDLSKEKDIVAWGQKRSPATYLDQLNKNGAAIMLAGAWGDTIFAPNQSAAFYEELTGPKRLEFRPGDHATAELPGLFGLPNDVWTDTERWFDHYLKGEDNGIDREQPVRLKSRSTSGYEGYPDWKSVNATRQKIALAGSTTIHTNVDSGADGGIVFLSSILDQVAKLPPVAAIPLLPRRWAAVWQSGKYATAQQVRGTAKVHTTVTPTEESGTLVAYLYDVGPLGLGKLVANAPYTFHGHTPGKPFGVDLDLFSTAYDVPAGHRLALVVDTVDPLYIEHNPSGARLTFSSPVNDPSYVSVPLRGQ
>NZ_CP049838.1|WP_171400324.1|7955870_7956617_-|hypothetical-protein
MNDDVRNIVLGVVAAGISAALGWLTRTYLWKRRLRRKQAFFGLPENSECLLVVNRDAGSPDLAVHRHDVFALLELAALIKDCGAGAEVVTQDVARQGFGERTEFCVGGPGSNRRMAAHIQAMLPGVRVNTDREPGPDRLAFQIGGEHHRMDPGVTEYVLLARLTAGRRREARPVFLFCGQRAINNQAATRYLVRNHERLARKHGNGSFVLLLKVVNSQAYGPDVVELVDDVTRAAQAPLPDTTIVTAT
>NZ_CP049838.1|WP_171400325.1|7956760_7958572_+|gamma-glutamyltransferase
MRRPVARKLSVLAVSAAVVTVGAAAPPAAERTTVAKVPVAVGYGGAVASVDADASAAGIEVLRKGGNAVDAAVATAAALGVTEPYSSGIGGGGYFVYYDAESRAVHTIDGRETAPLTADSGLFLENGKPLAFADAVSSGLGVGTPGTPATWATALKEWGSEKLGTVLKPAQRIARDGFTVDDTFRTQTAANETRFRYFPDTAKLFLPGGQLPVVGSTFKNPDLARTYEELARKGVGAIYRGDLGKDIVSTVNKPPVDPGSGWNARPGDLSAKDLAAYRAKLQAPTKTSYRGLGVYSIAPSSSGGTTVGEALNILEKTDLSKASEVQYLHRYLEASRIAFADRGRWVGDPAFEDVPTKQLLSQKYADSRACLIKDDAVLTSPVAPGDPRNPAACDTGGTAAPTTYEGENTTHLTVADKWGNVVSYTLTIEQTGGSGITVPGRGFLLNNELTDFSFAPAGPAVHDPNLPGPGKRPRSSISPTIVLDRHDKPVVALGSPGGATIITTVLQTLTEFLDRGLPLVDAIAAPRASQRNAAQTELEPALYDDTSPDGLRARLEAIGHSFKLNPEIGAATAVQRLPNGKWLAAAETVRRGGGSAQVVRPAP

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP049838_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049838_20

8414583-8414687

Orphan

Consensus_repeat	Method
ATCACGCCGGTTCGAATCCGGTCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049838_20

>merge|NZ_CP049838|20|8414583-8414687|CRISPRCasFinder
ATCACGCCGGTTCGAATCCGGTCGTCCGGATGCGTGCGCGGTCCCGTAGAGCAGAGGCAGACTCGCCACCTTCTCAGGGTGGATACGCCGGTTCGAATCCGGTCG

>NZ_CP049838|20|14|8414583-8414687|CRISPRCasFinder
ATCACGCCGGTTCGAATCCGGTCG	TCCGGATGCGTGCGCGGTCCCGTAGAGCAGAGGCAGACTCGCCACCTTCTCAGGGTG
GATACGCCGGTTCGAATCCGGTCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049838.1\|WP_171400673.1\|8414221_8414467_+\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NZ_CP049838.1\|WP_020129430.1\|8421690_8422665_-\|acyl-ACP-desaturase	unknown	unknown	gnl\|CDD\|153109
NZ_CP049838.1\|WP_171402344.1\|8425686_8426046_-\|SsgA-family-sporulation/cell-division-regulator	unknown	unknown	gnl\|CDD\|377399
NZ_CP049838.1\|WP_171400675.1\|8416098_8417304_+\|ribonuclease-inhibitor	unknown	unknown	gnl\|CDD\|238064
NZ_CP049838.1\|WP_171400674.1\|8414737_8416102_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187627
NZ_CP049838.1\|WP_171400672.1\|8413110_8413902_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319911
NZ_CP049838.1\|WP_171400665.1\|8401048_8402035_-\|DUF3048-domain-containing-protein	unknown	unknown	gnl\|CDD\|378618
NZ_CP049838.1\|WP_171400677.1\|8419160_8420567_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226382
NZ_CP049838.1\|WP_171400671.1\|8411970_8412996_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP049838.1\|WP_171400678.1\|8420761_8421604_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049838.1\|WP_171400679.1\|8422881_8423658_-\|N(G),N(G)-dimethylarginine-dimethylaminohydrolase	unknown	unknown	gnl\|CDD\|224747
NZ_CP049838.1\|WP_171400681.1\|8426387_8427443_+\|oxidoreductase	unknown	unknown	gnl\|CDD\|226855
NZ_CP049838.1\|WP_171402343.1\|8406005_8408150_-\|DUF1080-domain-containing-protein	unknown	unknown	gnl\|CDD\|368908
NZ_CP049838.1\|WP_171400666.1\|8402356_8403547_+\|glutathione-dependent-formaldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|176243
NZ_CP049838.1\|WP_171400670.1\|8410889_8411888_+\|multicopper-oxidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|259991
NZ_CP049838.1\|WP_171400676.1\|8417328_8419152_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NZ_CP049838.1\|WP_171400668.1\|8404934_8405972_+\|DNA-polymerase-domain-containing-protein	unknown	unknown	gnl\|CDD\|240135
NZ_CP049838.1\|WP_171400680.1\|8423796_8425419_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP049838.1\|WP_171400667.1\|8403747_8404824_-\|ATP-dependent-DNA-ligase	unknown	unknown	gnl\|CDD\|236191
NZ_CP049838.1\|WP_171400669.1\|8408212_8410690_-\|ThuA-domain-containing-protein	unknown	unknown	gnl\|CDD\|377643

Protein	Function_ID	Function_description	E-value
NZ_CP049838.1\|WP_171400673.1\|8414221_8414467_+\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	1.17521e-23
NZ_CP049838.1\|WP_020129430.1\|8421690_8422665_-\|acyl-ACP-desaturase	gnl\|CDD\|153109	cd01050, Acyl_ACP_Desat, Acyl ACP desaturase, ferritin-like diiron-binding domain. Acyl-Acyl Carrier Protein Desaturase (Acyl_ACP_Desat) is a mu-oxo-bridged diiron-carboxylate enzyme, which belongs to a broad superfamily of ferritin-like proteins and catalyzes the NADPH and O2-dependent formation of a cis-double bond in acyl-ACPs. Acyl-ACP desaturases are found in higher plants and a few bacterial species (Mycobacterium tuberculosis, M. leprae, M. avium and Streptomyces avermitilis, S. coelicolor). In plants, Acyl-ACP desaturase is a plastid-localized, covalently ACP linked, soluble desaturase that introduces the first double bound into saturated fatty acids, resulting in the corresponding monounsaturated fatty acid. Members of this class of soluble desaturases are specific for a particular substrate chain length and introduce the double bond between specific carbon atoms. For example, delta 9 stearoyl-ACP is specific for stearic acid and introduces a double bond between carbon 9 and 10 to yield oleic acid in the ACP-bound form. The enzymatic reaction requires molecular oxygen, NAD(P)H, NAD(P)H ferredoxin oxido-reductase and ferredoxin. The enzyme is active in the homodimeric form; the monomer consists mainly of alpha-helices with the catalytic diiron center buried within a four-helix bundle. Integral membrane fatty acid desaturases that introduce double bonds into fatty acid chains, acyl-CoA desaturases of animals, yeasts, and fungi, and acyl-lipid desaturases of cyanobacteria and higher plants, are distinct from soluble acyl-ACP desaturases, lack diiron centers, and are not included in this CD.	1.3316e-138
NZ_CP049838.1\|WP_171402344.1\|8425686_8426046_-\|SsgA-family-sporulation/cell-division-regulator	gnl\|CDD\|377399	pfam04686, SsgA, Streptomyces sporulation and cell division protein, SsgA. The precise function of SsgA is unknown. It has been found to be essential for spore formation, and to stimulate cell division.	3.3237e-35
NZ_CP049838.1\|WP_171400675.1\|8416098_8417304_+\|ribonuclease-inhibitor	gnl\|CDD\|238064	cd00116, LRR_RI, Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).	7.87032e-15
NZ_CP049838.1\|WP_171400674.1\|8414737_8416102_+\|SDR-family-oxidoreductase	gnl\|CDD\|187627	cd05369, TER_DECR_SDR_a, Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR. TTER is a peroxisomal protein with a proposed role in fatty acid elongation. Fatty acid synthesis is known to occur in the both endoplasmic reticulum and mitochondria; peroxisomal TER has been proposed as an additional fatty acid elongation system, it reduces the double bond at C-2 as the last step of elongation. This system resembles the mitochondrial system in that acetyl-CoA is used as a carbon donor. TER may also function in phytol metabolism, reducting phytenoyl-CoA to phytanoyl-CoA in peroxisomes. DECR processes double bonds in fatty acids to increase their utility in fatty acid metabolism; it reduces 2,4-dienoyl-CoA to an enoyl-CoA. DECR is active in mitochondria and peroxisomes. This subgroup has the Gly-rich NAD-binding motif of the classical SDR family, but does not display strong identity to the canonical active site tetrad, and lacks the characteristic Tyr at the usual position. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	1.11862e-10
NZ_CP049838.1\|WP_171400672.1\|8413110_8413902_-\|VOC-family-protein	gnl\|CDD\|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	7.62679e-29
NZ_CP049838.1\|WP_171400665.1\|8401048_8402035_-\|DUF3048-domain-containing-protein	gnl\|CDD\|378618	pfam11258, DUF3048, Protein of unknown function (DUF3048) N-terminal domain. Some members in this bacterial family of proteins are annotated as YerB. However currently no function is known. This entry represents the N-terminal domain.	1.80668e-41
NZ_CP049838.1\|WP_171400677.1\|8419160_8420567_-\|hypothetical-protein	gnl\|CDD\|226382	COG3864, COG3864, Uncharacterized protein conserved in bacteria [Function unknown].	2.94857e-10
NZ_CP049838.1\|WP_171400671.1\|8411970_8412996_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	4.85741e-99
NZ_CP049838.1\|WP_171400679.1\|8422881_8423658_-\|N(G),N(G)-dimethylarginine-dimethylaminohydrolase	gnl\|CDD\|224747	COG1834, COG1834, N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism].	2.27558e-39
NZ_CP049838.1\|WP_171400681.1\|8426387_8427443_+\|oxidoreductase	gnl\|CDD\|226855	COG4447, COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only].	1.25849e-19
NZ_CP049838.1\|WP_171402343.1\|8406005_8408150_-\|DUF1080-domain-containing-protein	gnl\|CDD\|368908	pfam06439, DUF1080, Domain of Unknown Function (DUF1080). This family has structural similarity to an endo-1,3-1,4-beta glucanase belonging to glycoside hydrolase family 16. However, the structure surrounding the active site differs from that of the endo-1,3-1,4-beta glucanase.	2.64046e-34
NZ_CP049838.1\|WP_171400666.1\|8402356_8403547_+\|glutathione-dependent-formaldehyde-dehydrogenase	gnl\|CDD\|176243	cd08283, FDH_like_1, Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1. Members identified as glutathione-dependent formaldehyde dehydrogenase(FDH), a member of the zinc-dependent/medium chain alcohol dehydrogenase family. FDH converts formaldehyde and NAD(P) to formate and NAD(P)H. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. MDH family uses NAD(H) as a cofactor in the interconversion of alcohols and aldehydes, or ketones. Like many zinc-dependent alcohol dehydrogenases (ADH) of the medium chain alcohol dehydrogenase/reductase family (MDR), these FDHs form dimers, with 4 zinc ions per dimer. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.	0
NZ_CP049838.1\|WP_171400670.1\|8410889_8411888_+\|multicopper-oxidase-domain-containing-protein	gnl\|CDD\|259991	cd14449, CuRO_1_2DMCO_NIR_like_2, The cupredoxin domain 1 of a two-domain laccase related to nitrite reductase. The two-domain laccase (small laccase) in this family differs significantly from all laccases. It resembles the two domain nitrite reductase in both sequence and structure. It consists of two cupredoxin domains and forms trimers, and hence resembles the quaternary structure of nitrite reductases more than that of large laccases. There are three trinuclear copper clusters in the enzyme localized between domains 1 and 2 of each pair of neighbor chains. Laccase is a blue multi-copper enzyme that catalyzes the oxidation of a variety of organic substrates coupled to the reduction of molecular oxygen to water. It displays broad substrate specificity, catalyzing the oxidation of a wide variety of aromatic, notably phenolic, and inorganic substances. Laccase has been implicated in a wide spectrum of biological activities. This subfamily has lost the type 1 (T1) copper binding site in domain 1 that is present in other two-domain laccases.	2.36712e-69
NZ_CP049838.1\|WP_171400676.1\|8417328_8419152_-\|AAA-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	3.7593e-05
NZ_CP049838.1\|WP_171400668.1\|8404934_8405972_+\|DNA-polymerase-domain-containing-protein	gnl\|CDD\|240135	cd04865, LigD_Pol_like_2, LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-homologous end joining (NHEJ)-mediated repair of DNA double-strand breaks (DSB). NHEJ-mediated DNA DSB repair is error-prone. It has been suggested that LigD Pol contributes to NHEJ-mediated DNA DSB repair in vivo, by filling in short 5'-overhangs with ribonucleotides; the filled in termini would then be sealed by the associated LigD ligase domain, resulting in short stretches of RNA incorporated into the genomic DNA. The Pol domains of PaeLigD and Mycobacterium tuberculosis (Mt)LigD are stimulated by manganese, are error-prone, and prefer adding rNTPs to dNTPs in vitro; however PaeLigD and MtLigD belong to other subgroups, proteins in this subgroup await functional characterization.	2.18381e-126
NZ_CP049838.1\|WP_171400680.1\|8423796_8425419_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	2.1564e-125
NZ_CP049838.1\|WP_171400667.1\|8403747_8404824_-\|ATP-dependent-DNA-ligase	gnl\|CDD\|236191	PRK08224, ligC, ATP-dependent DNA ligase; Reviewed.	0
NZ_CP049838.1\|WP_171400669.1\|8408212_8410690_-\|ThuA-domain-containing-protein	gnl\|CDD\|377643	pfam06283, ThuA, Trehalose utilisation. This family consists of several bacterial ThuA like proteins. ThuA appears to be involved in utilisation of trehalose. The thuA and thuB genes form part of the trehalose/sucrose transport operon thuEFGKAB, which is located on the pSymB megaplasmid. The thuA and thuB genes are induced in vitro by trehalose but not by sucrose and the extent of its induction depends on the concentration of trehalose available in the medium.	3.82156e-78

>NZ_CP049838.1|WP_171400673.1|8414221_8414467_+|WhiB-family-transcriptional-regulator
MYTDTIPTPDLGWQREALCAQTGAEFFFPEPGSSVREAKRICGMCEMRSACLEYALANDERFGVWGGMSEKERLNLRRPAR
>NZ_CP049838.1|WP_171400672.1|8413110_8413902_-|VOC-family-protein
MLTTRFVNGAPNWIDVGTSDIDGATSFYGALFDWRFRSAGPDAGGYGFFQLDGKTVAGGMQTAPGQGPPSWTVYFRTPDAQATAQAAEQKHGTVLFAPMDVMGQGTMAVLADQAGVPFGLWQPGRTKGVDVANEPGALCWVELYTPDVAAAAAFYNATLGLETSAAPFPGGTYTCVNPAGAGEEAMFGGIVPLADDPSEAETGAYWLPYFEVADADTIVAKAEELGGRVRMPATDVEGVGRIAKLADPYGARFAVIKSVPQEM
>NZ_CP049838.1|WP_171400671.1|8411970_8412996_+|LacI-family-DNA-binding-transcriptional-regulator
MTETASRPTLEAVAARAGVSRATVSRVVNGGDGVREPLVERVRRAVEELGYVPNQAARSLVTKRHDAVAVVIAEPETRVFADPFFALQLRGISKELTAHDNQLVLLLTEGRDDHARVARYLAGGHVDGALVFSLHLDDPLPGLIQGAGVPTVFGGRPGWSDGTRDVVYVDSDNRGGAREAVRLLAGLGRTRIAHITGPLDQTSAADRLDGYREVMGENDPRLVVESDFTPGGAERAMRELLDRCPDLDAVFAANDLAASGALRVLRERGRRVPEDVAVVGFDDMLPVAEQSDPPLTTVRQDIEEMGRIMARLLLRRLDRRVADEAPGGVVLPTTLVRRASA
>NZ_CP049838.1|WP_171400670.1|8410889_8411888_+|multicopper-oxidase-domain-containing-protein
MDRRGFNRRVLLGGAAAATSLSLGPRAVSADGPAKTAPAGGAVRHLKLYAEKLADGQLGYGFEKGKATIPGPLIEVNEGDTVHIEVENTLDVTASLHVHGLDYEISSDGTKLNRSDIEPGGTRTYTWRTHAPGRRADGTWRAGSAGYWHYHDHVVGTEHGTGGIRKGLYGPVIVRRKGDILPDATHTIVFNDMTINNRPAHSGPDFEATVGDRVEFVMITHGEYYHTFHMHGHRWADNRTGLLTGPDDPSQVVDNKIVGPADSFGFQVIAGEGVGAGAWMYHCHVQSHSDMGMVGLFLVKKPDGTIPGYEPHEPHESHESLEPDETGDAHEH
>NZ_CP049838.1|WP_171400669.1|8408212_8410690_-|ThuA-domain-containing-protein
MHLRGLSTRGRIRVTAVACATLVAGLLSAPAAGARPAPEPPLTTMSIKSPPGGANVRVLIFHGSAAAGDESPVVNAGIEAIERIGLSGPADQRFEVEATDDASVFTSGTRLGSYNAVVFLTGGGDVLDPEQEAGLEAYMEAGGGFLGVHDAARAEPYSDWFTGLIGARPATSSPTAVQRATVEVGDRRHPATGGLPLEWKRPDLWPNWVKNPSGEVHTVARVRESTYQPGTSANGADHPVSWCRDYDGGRSFYTGMGGTVSSYDETDFRTHLRGALLWTSRLVQADCKATITGNYKAERLTPANQPGQNDQIGEPHGLVTAPDGRVLYIGRGGADSSRPVITDWNNPDVGKGKGQIHVYDPATKKVTLAGELTVFGNKGGGDELVKVEEGLLGIELDPRFEQNGWVYLHYTPHSGVNRDTRMAERRVSRFTLDLATNRLDPGSEKVLLKWPVQVHSCCHAGGGLAWDSKGNLYIATGDNNSSGFSGGYSGNNPQPNFKGVSFADARRTAGNTHNLNGKILRIHPEPDGTYTLPAGNLFTGRETDEGGGKTRGEIYVMGVRNPARIFVDRTTDILYAGWVGPDAGEPSPVWGPAKYDTFAVITQASNRGWPYCMGNKQPYRDRNLPDPSQPLGWYDCDHPKNESPNNDGLVNLPPVTGNNIWYSPQGGAPDYPRDASGIPSYRQDQATYRLPWLKGGGQAAMNGPVYRYDAAGTSTAKWPAYWDGKWFVGDFYDADQPRNAVVMDPRTQGSGGLPVHSESLKRIVPVGNDGIKNLMDWKFGPDGALYVLDYGRGFFTSDAKSALWKVTYKGGGPTPTADGLARGAQ
>NZ_CP049838.1|WP_171402343.1|8406005_8408150_-|DUF1080-domain-containing-protein
MMLGLQAAPTAAQSEPAAAAQVLTWTAGDDITKYGSAPATAVAGQATIVFENSVATGNTMGMPHTLTFATSDPEFNDDVTLNILANPNDDLGGRHTAEVTLTPGRYFYHCTIPGHGQMQGILVVTEGGGEDTTPPETAAQVTGTQNAQGEYVGSASVAIGATDDGGSGVDGIQYAVGTAGDWIPYTAPVVVDQVGSHRIRYRAFDKAGNVSAEKTAAFTVVARPSDDTTPPDTSGTVSGEQNPDGTYIDMATVTVSASDTGSGVNTIEYTVGSGAWQPYTAPVMVHQVGTHTVRYRATDKAGNAAAEKSVRFTVVAATPQDTTPPVTGVTVEGTKNSGGAYVGNAKVTVSATDEHGSGVDRIEYSLDGGPYIAYSIPVVVDRAGPHTLVYRATDKAGNTSTARTVTFTVVSSQVPAPNCPEYDERLTVIVGTVDSGVPNRLTDKRCRINELIEDEKEWTSHALFLKHVKTVLDGLFGEGVVDQREYDAVQEAASRSGIGKPGQTEGYRTILDGSAGSFAKWQQVGGGSFAQNADGSITSGTTREGLGMLWFPERKYGDFSLKLQWRDDAPGTGNANSGVFVRFPWVHDHAEESRPEWVAIKYGHEVQVLDRPDGDMYKTGSVYGFDRVGLAGAGVTQKGTWNDYEIRVVDQHYSVYRNGVLINEFDNTGGQEFSPPRADDPGTDGRRFASGYLGLQVHGTTDVVSYRDIRIKEL
>NZ_CP049838.1|WP_171400668.1|8404934_8405972_+|DNA-polymerase-domain-containing-protein
MGDAVELEVAGRTVRLSSPDKVFFPERGFTKLDLARYYQAVAPGILRALRNRPTTLERYPDGVGGESFFQKRAPKNMPDWIPTAHITFPSGRSADEMCPTEEAAVLWAAQYGTLTFHPWPVRRDDVDRPDELRIDLDPQPGTDYDDAVHAAHELRAVLEEFGGLRGWPKTSGGRGLHVFVPIEPRWTFTQVRRAAIAVGREMERRLPERVTIKWWKEERGERIFIDYNQTARDRTIASAYSVRPRPHAPVSAPLRWEEVGDAHPGDFDLATMPARYAELGDVHADMDDHAFSLEALLELARRDEHDHGLGDLPYPPEYPKMPGEPKRVQPSRARHEDAPGGPGAS
>NZ_CP049838.1|WP_171400667.1|8403747_8404824_-|ATP-dependent-DNA-ligase
MDLPVMPPVKPMLAKSVAAIPPGMQYEAKWDGFRAIVFRDGAEIELGSRTGKPLTRYFPELVEALRERVPQRCVLDGEIVIAREGRLDFDALTERIHPADSRVRTLAERTPASFVAFDLLALDDRSLLDVPLSDRRELLTGALAGVPAPVHVAPATTDAEVAQRWFEEYEGAGLDGVIAKPLTLRYRQDERAMFKVKHERTADVVVAGYRFHKSGPVVGSLLLGLYDDRGALQHVGVSAAFSMKRRAELIEELEPLRMEDAAGHPWAAWAEEAAHETARLPGAPSRWSGKKDLSWVPLRPERVVEVAYDHMENGARFRHTARFRRWRPDRTPDSCTYAQLEEPVRYDLAEILGAPPAT
>NZ_CP049838.1|WP_171400666.1|8402356_8403547_+|glutathione-dependent-formaldehyde-dehydrogenase
MKAVTWQGKRDVRVDTVPDPTIQEPTDAVIRITSTGLCGSDLHLYEVLTPFMTPGDILGHEPMGIVEEVGAGVPDLRAGDRVVVPFQIACGNCWMCLSALPTQCETTQVTGEGMGAALFGYTRLYGAVPGAQAEYLRVPQAQFGPIKVPEGPPDDRFVYLSDVLPTAWQAVAYADIPQGGTVAVLGLGPIGDMACRIAQVRGAGRVFGVDLVGDRLRRARARGVETYDLRSFDSEKELVAAIRDETDGRGPDAVIDAVGTEAHGSAAARMIQNASALLPRKLSGPLAERFSVDRLAALHTAIELVRRGGTLSLVGVYGGMADPLPMLTMFDKQLQIRMGQANVRRWSDEILPYLTDEDPLGVDDFATHRLPLSDAPHAYEMFQHKQDGAVKVLMTP
>NZ_CP049838.1|WP_171400665.1|8401048_8402035_-|DUF3048-domain-containing-protein
MRTGPSAVAAALLTALLAIALAAGCTTTREPPTNDDGRSASQKPSPSGSTSPTAVAGSVLAVKIDNAPGARPQTGLDSADIVYVEQVEGGLSRLMAVYATRVPKAVGPVRSARESDLELLGQFERPVLAFSGAQGKLLPLIDRAPLDAVTPEDAAGDGAYYRGTDRAAPHNLYLRPSRLLPSAPGSAALTTGFRYGTAPSGGTAQASLTVRYPAARFSFSWSASRSRWLVSTDGAPTVTDGGQRVAPATVVVQYVKVRASGFHDFLGNNTPYTETVGSGKARVLRDGRVHDVNWKRATATDGTDFTTADGTPVAFAEGQVWVVFAQAP
>NZ_CP049838.1|WP_171400674.1|8414737_8416102_+|SDR-family-oxidoreductase
MGEDNGGAAFGPSVTDAELAAFHDVVGRLRALPVDDPVRLRAEQVAASFARDGRLRRRKGRGAEVAAADAAAMAATATGALDRREDAPLPAAGRGGRFHRPRACYVCKSAYQEVDTFYHRLCPDCAADNAARRSLSTDLSGRRVLLTGGRVKIGFQLALMMLRDGAQTVVTSRFPHDTVRRFRAEPGSGQWLDRLTVVAVDLRDPRQVLGLCEELRREGEPLDILVNNAAQTVRRPPESYALLAAGERDALPEGTRRAPGFTPMRMLEGLGGSVSALPAALREADEAGLLPDPSPENSWSARLGALDPAEVLETQLVNALAPALLCDRLLPLLLASPHPRRYVVNVTAVEGRFAVRNKMPGHPHTNMAKAALNMLTRTSAAALADQGVHMCAVDTGWITDENPAPKKARMAGAGFRTPLDIVDGAARVYDPIVRGEAGHPVSGVFLKDYREAQW
>NZ_CP049838.1|WP_171400675.1|8416098_8417304_+|ribonuclease-inhibitor
MSEENAAGPERAGFAGVPHVVPRPLADLAPLLDWLRAGRPAGERLDFAAGTALPDGRLDLCKQGLGAEGAALVAEALADGPSPVRHLLLGTDALGDDGAATVAGTSAPVETLYLGCNGITAGGACRIADQLRASPQVVTGVWLKRNPLGRGGGRAAAELIESVRTLRTLDLVQTGLDAAGVTVLADALPAAAGNGRRVERLFVGGNPLGEAGAEALAAVVAAGAIDELYVSAARLGDGGALRIADALERAPYGRLTRLSVASNGIGPSAAARLVGAATVAGVTLLDLGRVRAAAVLGAVDNRLDLASAESIGRTLAAGEHRLAHLVLRHTGLRSREAHRILDHAPRAVTATRFVLGQGVAATVKRRLAALSADVPAPAVPPDVAAVRSVHRTAAPEASAED
>NZ_CP049838.1|WP_171400676.1|8417328_8419152_-|AAA-family-ATPase
MSTRTEYPHDTGDRPAPGEVSRLEGFIDAMIDLGQTGQVFGEHGIGKTATFFSHVARAHPGTELVYVPAANLTPDDLLVNAPVRDPRSGQLVLRQLVMSQLKPGRPFVLLIDDSLQAGDTIQSQLMQIACDWTLGEHDLRALGCVGVFLTDNESQAETSARRSDLALLDRMVTMRISANDTSWRRHLAVKYRPWDLRPVFAVWASLSPALRELLSPRTLDHVLANAREGFPLRWGLPLIDGERLRLAEPGPDGRPGQNRTAEILDRLAQALGVANPATVPDPVRQVVRAALRNRWTVLLQGPPGCGKTELVRETVRAGLGRDALYFSLPVTNVEDLCAPVPSPDGTLDNLLAAKFTGPEPKAIVWDEYNRPKDKAAFAKLMEITQEWSLAGKRIENLRAQIAVQNPPYHLGRKLLVSRNNIAQATRFTASLEVAPEDIPANEWLLARYGADAETVLEWWKHDIDEEGRAWITKRTLERLIKLHRRGLPLEMATVYLGDGEYAPVPLTALIDRLKGRPVTGLRELARDADAWEARLRRAAARSDEGGDDSDVVHQILANAELSQLRRHHAVVARLVAHLPAKLRATYLVGASEQQQKFWMGVFTGMRR
>NZ_CP049838.1|WP_171400677.1|8419160_8420567_-|hypothetical-protein
MGYGERGRRRPPVVDLADRRALEAYRPAEPEVVARARQLKEAALLDFGLTESAVASWLYTKCHHQIPTTAVDTAAVVASGDGTCLLLYNPDFFVGLGLDGVKFVLFHEARHLVHRHLLAEPELREDPVFELAAEVSINHVALVRLGREELPLLNGRPTGVDPRQVHELYVEDLTAHGLEPVSYGTFTRTDTRVYGELKRMRHPPVPEERLCVHLGAGAVPADQETVDAVTSSALLNSLLAARRGHAGAERELLDLMGRTEGDSARAARLWGRLGAGTLRGGTTRTRTVDWWQRWLVDVLGSKLRDGERLVYPKKRGALLAALGQDPMLARRGPVRDKVLVIAYDTSGSMPHHVVHWLTELVGRIDGVEAHWLSFDGVVMPFRPGERVYGGGGTSFQAVADHVEGRTEVNGRRFDERPDAVVVLTDGYAPPITPAEPDRWIWLITEGGHEWPETHTPAMDCHRVTTGSR
>NZ_CP049838.1|WP_171400678.1|8420761_8421604_-|hypothetical-protein
MGDSDTVQQAVGFLLGLTDEDTADRIRARIGLPPATAENAATIQRRLNRAWTWPTAPASVVLWVLEQDDPALNAVVWRFVGNDLGLRRALARGVPFGPGRTKPLAVRSIHERQEPDIPESYVRYGLVGALRKANSMPAARAAASMVLTRGDWATVGAAHDEFALPGYPRWALSVRPDCPPALRARFGSHPKFTHRLRQAGVLDSPAQYATAHGPASRVLEVLSLGHVMFPARVREAEDALRPLVRDHLGGREEAWAVLAQLIDTFHGTAPELVVTAGAIA
>NZ_CP049838.1|WP_020129430.1|8421690_8422665_-|acyl-ACP-desaturase
MTITSPHLGSPAVWTDAKLLHALEEVVETELNRHLKVTKDWMPHEYVPWSDGRNFPGFFEDGEAWEKGQSKVTEIGRIALVVNLLTEDNLPSYHHEIASLFGRDGAWGTWVHRWTAEEGRHGIVMRDYLLASRAVDPDKLEQFRMSHMSEGFESDNRHSMLHSVAYVAFQELATRVSHRNTGHQSGDPVCDRMLARIATDENLHMVFYRNLLKAAFELAPDLTMQAVRDVLVNFRMPGHGMPGFERFAAQMAIGEVYNLRIHHDDVIQPVLRFLKVMEVDGLGPEGQKAQEEIGLYMGGLDSEASKFDEKLAARKARMAARAAG
>NZ_CP049838.1|WP_171400679.1|8422881_8423658_-|N(G),N(G)-dimethylarginine-dimethylaminohydrolase
MPSKKALIRRPSPRLAEGLVTHVEREKVDVELALEQWEAYAEALRAHGWETVEVDPADDCPDSVFVEDTVVMYKNVALIARSGAESRRDETLGVEEAVARLGCSVNWIWEPGTLDGGDVLKVGDTIYVGRGGRTNAAGVQQVRAAFEPLGARVVAVPVSKVLHLKSAVTALPDGTVIGHIPKVDRPSLFPRFLSVPEEAGSHVVLLGGPQVLISAAAPKTADLLADLGHEPVVVDIGEFEKLEGCVTCLSVRLRELYA
>NZ_CP049838.1|WP_171400680.1|8423796_8425419_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MTHSITCTSLAFSWPDGTPVFDGLDVAFGPGRTGLVGVNGSGKSTLLKLIAGELTPSDGTVRLAGEVGHLPQNVTLDTTLKVDAALGIAPQRAALHAIEAGDASARHFETVGDDWDVEERALATLGELGLGHIDLDRTIGEVSGGESVLLRLAALLLRRPDVLLLDEPTNNLDLYARRRLYSAVTSWPGVLIVVSHDRELLDLVDQIADLRAGEVTWYGGNFSAYEEALATEQEAAERMVRVAEADLKKQKRELVDAQVTLARRKRYGQKMSDQKREPKIVMGARKRAAQESAGKYRIMHEEKLAKAKERLDDAVEAVRDDDEIRVELPYTAVPPGREVLLLQDLRLAYGARVDGGFDLRGPERVALVGRNGAGKTTLLRTIAGELAPEAGEAHAHVPLRFLPQRLDLLDGELTVAENVARFAPGATNNRIRARLARFLFRGARADQKAATLSGGERFRASLAALMLAEPAPQLLMLDEPTNSLDMASVRQLTTALESYEGALIVASHDLPFLESIGITRWLLLDGELRETTASEVTDPA
>NZ_CP049838.1|WP_171402344.1|8425686_8426046_-|SsgA-family-sporulation/cell-division-regulator
MQSIPATLSYDRQDPFAVRMTFPAPATLEGVEVCWTFARDLLAAGLHDAEGHGDVRVRPYGYGRTVLEFHAPEGTAVVHVHTEKILDFLRATSELVPAGTEYRQLDLDHDLAELMRDAR
>NZ_CP049838.1|WP_171400681.1|8426387_8427443_+|oxidoreductase
MVAAACGAAALALLTALPAEAHTPRPAAPHWDLKDTGTTAVRFRGLAAVDRHTAWVSGTEGTVLRTTDGGENWRNVSPPGAADLQFRDIEAFDARRAVVLAIGEGEASRVYRTEDGGTTWTESFRNTDAHAFYDCLTFFDRRHGLAMSDPVGGKFRILSTADGGRSWKVLPNDGMPAALDGEAGFAASGQCLVASGTKDVWLATGGAARARVLHSSDRGLTWTAADTPIPAGDPARGVFAVAFRDRTQGLAVGGDYRADQPSPRAAAATGDAGRTWRPAATPPPAYRSGVAWLPHSRSAALAVGPTGTDLTTDAGRTWRTLDTGSYDTVDCTPDLGCWAAGEQGRVARLES

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP049838_17	17.2\|6550163\|38\|NZ_CP049838\|PILER-CR	6550163-6550200	38	NZ_CP049838.1	6549549-6549586	0	1.0
NZ_CP049838_3	3.2\|2771618\|19\|NZ_CP049838\|CRISPRCasFinder	2771618-2771636	19	NZ_CP049838.1	8234075-8234093	2	0.895
NZ_CP049838_5	5.2\|4231900\|19\|NZ_CP049838\|CRT	4231900-4231918	19	NZ_CP049838.1	7428202-7428220	2	0.895
NZ_CP049838_5	5.2\|4231900\|19\|NZ_CP049838\|CRT	4231900-4231918	19	NZ_CP049838.1	8612045-8612063	2	0.895
NZ_CP049838_5	5.4\|4231978\|19\|NZ_CP049838\|CRT	4231978-4231996	19	NZ_CP049838.1	7428202-7428220	2	0.895
NZ_CP049838_5	5.4\|4231978\|19\|NZ_CP049838\|CRT	4231978-4231996	19	NZ_CP049838.1	8612045-8612063	2	0.895
NZ_CP049838_10	10.2\|5259222\|66\|NZ_CP049838\|PILER-CR	5259222-5259287	66	NZ_CP049838.1	5259369-5259434	6	0.909
NZ_CP049838_17	17.1\|6550044\|79\|NZ_CP049838\|PILER-CR	6550044-6550122	79	NZ_CP049838.1	6549442-6549520	19	0.759

1. spacer 17.2|6550163|38|NZ_CP049838|PILER-CR matches to position: 6549549-6549586, mismatch: 0, identity: 1.0

gcttcggccgtgtcgacggcggcttcggccggggccgc	CRISPR spacer
gcttcggccgtgtcgacggcggcttcggccggggccgc	Protospacer
**************************************

2. spacer 3.2|2771618|19|NZ_CP049838|CRISPRCasFinder matches to position: 8234075-8234093, mismatch: 2, identity: 0.895

cggaagcccggaaggtcac	CRISPR spacer
cggaagcacggaagggcac	Protospacer
******* ******* ***

3. spacer 5.2|4231900|19|NZ_CP049838|CRT matches to position: 7428202-7428220, mismatch: 2, identity: 0.895

acagggcgccggacgggct	CRISPR spacer
acagggcgctgtacgggct	Protospacer
*********.* *******

4. spacer 5.2|4231900|19|NZ_CP049838|CRT matches to position: 8612045-8612063, mismatch: 2, identity: 0.895

acagggcgccggacgggct	CRISPR spacer
accgggcgccggaccggct	Protospacer
** *********** ****

5. spacer 5.4|4231978|19|NZ_CP049838|CRT matches to position: 7428202-7428220, mismatch: 2, identity: 0.895

acagggcgccggacgggct	CRISPR spacer
acagggcgctgtacgggct	Protospacer
*********.* *******

6. spacer 5.4|4231978|19|NZ_CP049838|CRT matches to position: 8612045-8612063, mismatch: 2, identity: 0.895

acagggcgccggacgggct	CRISPR spacer
accgggcgccggaccggct	Protospacer
** *********** ****

7. spacer 10.2|5259222|66|NZ_CP049838|PILER-CR matches to position: 5259369-5259434, mismatch: 6, identity: 0.909

tcacgggcgccccggtggcggctgccgaagcaccggatccccgatgtgtcccatgcccca	CRISPR spacer
tcacgggcgccccggtggcggctgccgaagcaccggatccccgatgtgtcccatgcccca	Protospacer
************************************************************

8. spacer 17.1|6550044|79|NZ_CP049838|PILER-CR matches to position: 6549442-6549520, mismatch: 19, identity: 0.759

tggcttccgcttcctgggtggcctgggccgggatgtcggccgtggtggccgtcgtctcgg	CRISPR spacer
tggcttccgcttcctgggtggcctgggccgggatgtcggccgtggtggccgtcgtctcgg	Protospacer
************************************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP049838_13	13.5\|5980220\|22\|NZ_CP049838\|CRT	5980220-5980241	22	NZ_CP024907	Paraburkholderia caledonica strain PHRS4 plasmid pPHRS4, complete sequence	296162-296183	2	0.909
NZ_CP049838_13	13.5\|5980220\|22\|NZ_CP049838\|CRT	5980220-5980241	22	NZ_CP054028	Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence	1555635-1555656	2	0.909
NZ_CP049838_13	13.7\|5980316\|22\|NZ_CP049838\|CRT	5980316-5980337	22	NZ_CP024907	Paraburkholderia caledonica strain PHRS4 plasmid pPHRS4, complete sequence	296162-296183	2	0.909
NZ_CP049838_13	13.7\|5980316\|22\|NZ_CP049838\|CRT	5980316-5980337	22	NZ_CP054028	Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence	1555635-1555656	2	0.909
NZ_CP049838_1	1.1\|2246741\|31\|NZ_CP049838\|CRISPRCasFinder	2246741-2246771	31	NZ_CP018001	Rhizobium sp. Y9 plasmid pY9, complete sequence	260143-260173	5	0.839
NZ_CP049838_1	1.1\|2246741\|31\|NZ_CP049838\|CRISPRCasFinder	2246741-2246771	31	NC_022536	Rhizobium sp. IRBG74 plasmid IRBL74_p, complete sequence	453791-453821	5	0.839
NZ_CP049838_1	1.1\|2246741\|31\|NZ_CP049838\|CRISPRCasFinder	2246741-2246771	31	CP036360	Agrobacterium sp. 33MFTa1.1 plasmid p_JBx_073812, complete sequence	279771-279801	5	0.839
NZ_CP049838_3	3.1\|2771562\|27\|NZ_CP049838\|CRISPRCasFinder	2771562-2771588	27	NZ_CP032323	Azospirillum brasilense strain MTCC4035 plasmid p2, complete sequence	813913-813939	5	0.815
NZ_CP049838_3	3.1\|2771562\|27\|NZ_CP049838\|CRISPRCasFinder	2771562-2771588	27	NZ_CP049359	Deinococcus wulumuqiensis R12 plasmid unnamed2, complete sequence	88972-88998	5	0.815
NZ_CP049838_3	3.1\|2771562\|27\|NZ_CP049838\|CRISPRCasFinder	2771562-2771588	27	NZ_CP007795	Azospirillum brasilense strain Az39 plasmid AbAZ39_p2, complete sequence	293363-293389	5	0.815
NZ_CP049838_3	3.1\|2771562\|27\|NZ_CP049838\|CRISPRCasFinder	2771562-2771588	27	NZ_CP032341	Azospirillum brasilense strain MTCC4038 plasmid p2, complete sequence	517358-517384	5	0.815
NZ_CP049838_3	3.1\|2771562\|27\|NZ_CP049838\|CRISPRCasFinder	2771562-2771588	27	NZ_CP012916	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p2, complete sequence	531254-531280	5	0.815
NZ_CP049838_3	3.1\|2771562\|27\|NZ_CP049838\|CRISPRCasFinder	2771562-2771588	27	NZ_CP043960	Streptomyces tendae strain 139 plasmid unnamed1, complete sequence	138583-138609	5	0.815
NZ_CP049838_6	6.1\|4675150\|27\|NZ_CP049838\|CRISPRCasFinder	4675150-4675176	27	NC_017326	Sinorhizobium meliloti SM11 plasmid pSmeSM11d, complete sequence	391564-391590	5	0.815
NZ_CP049838_6	6.1\|4675150\|27\|NZ_CP049838\|CRISPRCasFinder	4675150-4675176	27	NC_018701	Sinorhizobium meliloti Rm41 plasmid pSYMB, complete sequence	386503-386529	5	0.815
NZ_CP049838_6	6.1\|4675150\|27\|NZ_CP049838\|CRISPRCasFinder	4675150-4675176	27	NZ_CP021802	Sinorhizobium meliloti strain USDA1021 plasmid psymB, complete sequence	1018430-1018456	5	0.815
NZ_CP049838_6	6.1\|4675150\|27\|NZ_CP049838\|CRISPRCasFinder	4675150-4675176	27	NZ_CP021820	Sinorhizobium meliloti strain M162 plasmid psymB, complete sequence	746204-746230	5	0.815
NZ_CP049838_6	6.1\|4675150\|27\|NZ_CP049838\|CRISPRCasFinder	4675150-4675176	27	NZ_CP021810	Sinorhizobium meliloti strain Rm41 plasmid psymB, complete sequence	1175297-1175323	5	0.815
NZ_CP049838_6	6.1\|4675150\|27\|NZ_CP049838\|CRISPRCasFinder	4675150-4675176	27	NZ_CP021218	Sinorhizobium meliloti RU11/001 plasmid pSymB, complete sequence	540420-540446	5	0.815
NZ_CP049838_7	7.2\|4931265\|33\|NZ_CP049838\|CRT	4931265-4931297	33	NZ_LR134446	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 4, complete sequence	52111-52143	5	0.848
NZ_CP049838_11	11.1\|5323710\|26\|NZ_CP049838\|CRISPRCasFinder	5323710-5323735	26	NZ_CP049360	Deinococcus wulumuqiensis R12 plasmid unnamed3, complete sequence	30029-30054	5	0.808
NZ_CP049838_6	6.1\|4675150\|27\|NZ_CP049838\|CRISPRCasFinder	4675150-4675176	27	NZ_CP013369	Burkholderia ubonensis strain RF23-BP41 plasmid pRF23, complete sequence	223619-223645	6	0.778
NZ_CP049838_6	6.1\|4675150\|27\|NZ_CP049838\|CRISPRCasFinder	4675150-4675176	27	NZ_CP017564	Paraburkholderia sprentiae WSM5005 plasmid pl3WSM5005, complete sequence	28023-28049	6	0.778
NZ_CP049838_1	1.1\|2246741\|31\|NZ_CP049838\|CRISPRCasFinder	2246741-2246771	31	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	263458-263488	8	0.742
NZ_CP049838_7	7.2\|4931265\|33\|NZ_CP049838\|CRT	4931265-4931297	33	NC_022995	Burkholderia sp. M701 plasmid pM7012 DNA, complete sequence	440231-440263	8	0.758
NZ_CP049838_7	7.3\|4931319\|30\|NZ_CP049838\|CRT	4931319-4931348	30	NZ_AP022338	Mameliella alba strain KU6B plasmid pKUB257, complete sequence	54371-54400	8	0.733
NZ_CP049838_7	7.3\|4931319\|30\|NZ_CP049838\|CRT	4931319-4931348	30	NZ_CP022775	Ralstonia solanacearum strain T12 plasmid unnamed, complete sequence	741727-741756	8	0.733
NZ_CP049838_7	7.3\|4931319\|30\|NZ_CP049838\|CRT	4931319-4931348	30	NC_014310	Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence	736953-736982	8	0.733
NZ_CP049838_7	7.3\|4931319\|30\|NZ_CP049838\|CRT	4931319-4931348	30	NZ_CP022762	Ralstonia solanacearum strain T95 plasmid unnamed, complete sequence	636910-636939	8	0.733
NZ_CP049838_7	7.3\|4931319\|30\|NZ_CP049838\|CRT	4931319-4931348	30	NZ_CP023017	Ralstonia solanacearum strain SL3022 plasmid unnamed, complete sequence	702674-702703	8	0.733
NZ_CP049838_7	7.3\|4931319\|30\|NZ_CP049838\|CRT	4931319-4931348	30	NZ_CP014703	Ralstonia solanacearum strain KACC 10722 plasmid, complete sequence	636025-636054	8	0.733
NZ_CP049838_7	7.3\|4931319\|30\|NZ_CP049838\|CRT	4931319-4931348	30	NZ_CP022760	Ralstonia solanacearum strain T98 plasmid unnamed, complete sequence	638857-638886	8	0.733
NZ_CP049838_7	7.3\|4931319\|30\|NZ_CP049838\|CRT	4931319-4931348	30	NZ_CP022789	Ralstonia solanacearum strain SL3175 plasmid unnamed, complete sequence	638847-638876	8	0.733
NZ_CP049838_7	7.3\|4931319\|30\|NZ_CP049838\|CRT	4931319-4931348	30	NZ_CP022771	Ralstonia solanacearum strain T51 plasmid unnamed, complete sequence	636898-636927	8	0.733
NZ_CP049838_7	7.3\|4931319\|30\|NZ_CP049838\|CRT	4931319-4931348	30	NZ_CP022777	Ralstonia solanacearum strain T11 plasmid unnamed, complete sequence	636916-636945	8	0.733
NZ_CP049838_7	7.3\|4931319\|30\|NZ_CP049838\|CRT	4931319-4931348	30	NZ_CP022799	Ralstonia solanacearum strain SL2064 plasmid unnamed, complete sequence	636895-636924	8	0.733
NZ_CP049838_7	7.3\|4931319\|30\|NZ_CP049838\|CRT	4931319-4931348	30	NZ_CP022764	Ralstonia solanacearum strain T82 plasmid unnamed, complete sequence	741791-741820	8	0.733
NZ_CP049838_7	7.3\|4931319\|30\|NZ_CP049838\|CRT	4931319-4931348	30	NZ_CP022797	Ralstonia solanacearum strain SL2312 plasmid unnamed, complete sequence	741791-741820	8	0.733
NZ_CP049838_7	7.3\|4931319\|30\|NZ_CP049838\|CRT	4931319-4931348	30	NZ_CP022758	Ralstonia solanacearum strain T101 plasmid unnamed, complete sequence	741777-741806	8	0.733
NZ_CP049838_17	17.2\|6550163\|38\|NZ_CP049838\|PILER-CR	6550163-6550200	38	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	2370954-2370991	8	0.789
NZ_CP049838_7	7.2\|4931265\|33\|NZ_CP049838\|CRT	4931265-4931297	33	MT986029	Gordonia phage Linetti, complete genome	29362-29394	9	0.727
NZ_CP049838_1	1.1\|2246741\|31\|NZ_CP049838\|CRISPRCasFinder	2246741-2246771	31	NZ_CP023524	Burkholderia gladioli pv. gladioli strain FDAARGOS_389 plasmid unnamed, complete sequence	66900-66930	10	0.677

1. spacer 13.5|5980220|22|NZ_CP049838|CRT matches to NZ_CP024907 (Paraburkholderia caledonica strain PHRS4 plasmid pPHRS4, complete sequence) position: , mismatch: 2, identity: 0.909

tcgcgtgctggcgcgcggctgc	CRISPR spacer
gctcgtgctggcgcgcggctgc	Protospacer
 * *******************

2. spacer 13.5|5980220|22|NZ_CP049838|CRT matches to NZ_CP054028 (Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence) position: , mismatch: 2, identity: 0.909

tcgcgtgctggcgcgcggctgc	CRISPR spacer
ccgggtgctggcgcgcggctgc	Protospacer
.** ******************

3. spacer 13.7|5980316|22|NZ_CP049838|CRT matches to NZ_CP024907 (Paraburkholderia caledonica strain PHRS4 plasmid pPHRS4, complete sequence) position: , mismatch: 2, identity: 0.909

tcgcgtgctggcgcgcggctgc	CRISPR spacer
gctcgtgctggcgcgcggctgc	Protospacer
 * *******************

4. spacer 13.7|5980316|22|NZ_CP049838|CRT matches to NZ_CP054028 (Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence) position: , mismatch: 2, identity: 0.909

tcgcgtgctggcgcgcggctgc	CRISPR spacer
ccgggtgctggcgcgcggctgc	Protospacer
.** ******************

5. spacer 1.1|2246741|31|NZ_CP049838|CRISPRCasFinder matches to NZ_CP018001 (Rhizobium sp. Y9 plasmid pY9, complete sequence) position: , mismatch: 5, identity: 0.839

tctcggcagcggcgcatccacccagcccgtc	CRISPR spacer
gctgagcagcgccgcatccaccctgcccgtc	Protospacer
 ** .****** *********** *******

6. spacer 1.1|2246741|31|NZ_CP049838|CRISPRCasFinder matches to NC_022536 (Rhizobium sp. IRBG74 plasmid IRBL74_p, complete sequence) position: , mismatch: 5, identity: 0.839

tctcggcagcggcgcatccacccagcccgtc	CRISPR spacer
gctgagcagcgccgcatccaccctgcccgtc	Protospacer
 ** .****** *********** *******

7. spacer 1.1|2246741|31|NZ_CP049838|CRISPRCasFinder matches to CP036360 (Agrobacterium sp. 33MFTa1.1 plasmid p_JBx_073812, complete sequence) position: , mismatch: 5, identity: 0.839

tctcggcagcggcgcatccacccagcccgtc	CRISPR spacer
gctgagcagcgccgcatccaccctgcccgtc	Protospacer
 ** .****** *********** *******

8. spacer 3.1|2771562|27|NZ_CP049838|CRISPRCasFinder matches to NZ_CP032323 (Azospirillum brasilense strain MTCC4035 plasmid p2, complete sequence) position: , mismatch: 5, identity: 0.815

cagcggcacggaggtccagcggcacgg	CRISPR spacer
cagcgggacggagggccagcggcagca	Protospacer
****** ******* *********  .

9. spacer 3.1|2771562|27|NZ_CP049838|CRISPRCasFinder matches to NZ_CP049359 (Deinococcus wulumuqiensis R12 plasmid unnamed2, complete sequence) position: , mismatch: 5, identity: 0.815

cagcggcacggaggtccagcggcacgg	CRISPR spacer
atgcggcacgcaagtccagcggcacgc	Protospacer
  ******** *.*************

10. spacer 3.1|2771562|27|NZ_CP049838|CRISPRCasFinder matches to NZ_CP007795 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p2, complete sequence) position: , mismatch: 5, identity: 0.815

cagcggcacggaggtccagcggcacgg	CRISPR spacer
cagcgggacggagggccagcggcagca	Protospacer
****** ******* *********  .

11. spacer 3.1|2771562|27|NZ_CP049838|CRISPRCasFinder matches to NZ_CP032341 (Azospirillum brasilense strain MTCC4038 plasmid p2, complete sequence) position: , mismatch: 5, identity: 0.815

cagcggcacggaggtccagcggcacgg	CRISPR spacer
cagcgggacggagggccagcggcagca	Protospacer
****** ******* *********  .

12. spacer 3.1|2771562|27|NZ_CP049838|CRISPRCasFinder matches to NZ_CP012916 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p2, complete sequence) position: , mismatch: 5, identity: 0.815

cagcggcacggaggtccagcggcacgg	CRISPR spacer
cagcgggacggagggccagcggcagca	Protospacer
****** ******* *********  .

13. spacer 3.1|2771562|27|NZ_CP049838|CRISPRCasFinder matches to NZ_CP043960 (Streptomyces tendae strain 139 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.815

cagcggcacggaggtccagcggcacgg	CRISPR spacer
gttcggcaccgaggtccagcagcacgg	Protospacer
   ****** **********.******

14. spacer 6.1|4675150|27|NZ_CP049838|CRISPRCasFinder matches to NC_017326 (Sinorhizobium meliloti SM11 plasmid pSmeSM11d, complete sequence) position: , mismatch: 5, identity: 0.815

aaggtcgcccgctggcgcaagtcgacg	CRISPR spacer
aacgtcgcccgctggcgcatgtctccc	Protospacer
** **************** ***  *

15. spacer 6.1|4675150|27|NZ_CP049838|CRISPRCasFinder matches to NC_018701 (Sinorhizobium meliloti Rm41 plasmid pSYMB, complete sequence) position: , mismatch: 5, identity: 0.815

aaggtcgcccgctggcgcaagtcgacg	CRISPR spacer
aacgtcgcccgctggcgcatgtctccc	Protospacer
** **************** ***  *

16. spacer 6.1|4675150|27|NZ_CP049838|CRISPRCasFinder matches to NZ_CP021802 (Sinorhizobium meliloti strain USDA1021 plasmid psymB, complete sequence) position: , mismatch: 5, identity: 0.815

aaggtcgcccgctggcgcaagtcgacg	CRISPR spacer
aacgtcgcccgctggcgcatgtctccc	Protospacer
** **************** ***  *

17. spacer 6.1|4675150|27|NZ_CP049838|CRISPRCasFinder matches to NZ_CP021820 (Sinorhizobium meliloti strain M162 plasmid psymB, complete sequence) position: , mismatch: 5, identity: 0.815

aaggtcgcccgctggcgcaagtcgacg	CRISPR spacer
aacgtcgcccgctggcgcatgtctccc	Protospacer
** **************** ***  *

18. spacer 6.1|4675150|27|NZ_CP049838|CRISPRCasFinder matches to NZ_CP021810 (Sinorhizobium meliloti strain Rm41 plasmid psymB, complete sequence) position: , mismatch: 5, identity: 0.815

aaggtcgcccgctggcgcaagtcgacg	CRISPR spacer
aacgtcgcccgctggcgcatgtctccc	Protospacer
** **************** ***  *

19. spacer 6.1|4675150|27|NZ_CP049838|CRISPRCasFinder matches to NZ_CP021218 (Sinorhizobium meliloti RU11/001 plasmid pSymB, complete sequence) position: , mismatch: 5, identity: 0.815

aaggtcgcccgctggcgcaagtcgacg	CRISPR spacer
aacgtcgcccgctggcgcatgtctccc	Protospacer
** **************** ***  *

20. spacer 7.2|4931265|33|NZ_CP049838|CRT matches to NZ_LR134446 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 4, complete sequence) position: , mismatch: 5, identity: 0.848

-gggcatgcccccgccggggaagccgccggtgcc	CRISPR spacer
gccgcctg-ccccgccggggaagccgccgttgcc	Protospacer
   ** ** ******************** ****

21. spacer 11.1|5323710|26|NZ_CP049838|CRISPRCasFinder matches to NZ_CP049360 (Deinococcus wulumuqiensis R12 plasmid unnamed3, complete sequence) position: , mismatch: 5, identity: 0.808

aacgaccacggcaagtacaaccacgg	CRISPR spacer
cacgacctcggcaagtacaacccaga	Protospacer
 ****** **************  *.

22. spacer 6.1|4675150|27|NZ_CP049838|CRISPRCasFinder matches to NZ_CP013369 (Burkholderia ubonensis strain RF23-BP41 plasmid pRF23, complete sequence) position: , mismatch: 6, identity: 0.778

aaggtcgcccgctggcgcaagtcgacg	CRISPR spacer
cagttcgcccgctggcgcacgtcgggc	Protospacer
 ** *************** ****.

23. spacer 6.1|4675150|27|NZ_CP049838|CRISPRCasFinder matches to NZ_CP017564 (Paraburkholderia sprentiae WSM5005 plasmid pl3WSM5005, complete sequence) position: , mismatch: 6, identity: 0.778

aaggtcgcccgctggcgcaagtcgacg	CRISPR spacer
tcggtcggccgctggagcaagtcgagt	Protospacer
  ***** ******* *********

24. spacer 1.1|2246741|31|NZ_CP049838|CRISPRCasFinder matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 8, identity: 0.742

tctcggcagcggcgcatccacccagcccgtc	CRISPR spacer
ttcgggcagcgccgcatccacccagcggcgc	Protospacer
*.. ******* **************    *

25. spacer 7.2|4931265|33|NZ_CP049838|CRT matches to NC_022995 (Burkholderia sp. M701 plasmid pM7012 DNA, complete sequence) position: , mismatch: 8, identity: 0.758

gggcatgcccccgccggggaagccgccggtgcc	CRISPR spacer
gcctgtgaccccgccggggacgccgccggtggt	Protospacer
*  ..** ************ ********** .

26. spacer 7.3|4931319|30|NZ_CP049838|CRT matches to NZ_AP022338 (Mameliella alba strain KU6B plasmid pKUB257, complete sequence) position: , mismatch: 8, identity: 0.733

ctggccctgaccctggttctgcgtgttgcc	CRISPR spacer
atggcccagaccctggttcagcgtgccaag	Protospacer
 ****** *********** *****...

27. spacer 7.3|4931319|30|NZ_CP049838|CRT matches to NZ_CP022775 (Ralstonia solanacearum strain T12 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

ctggccctgaccctggttctgcgtgttgcc	CRISPR spacer
acggccctgaccctggttctacgcggcgtt	Protospacer
 .******************.**.* .*..

28. spacer 7.3|4931319|30|NZ_CP049838|CRT matches to NC_014310 (Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence) position: , mismatch: 8, identity: 0.733

ctggccctgaccctggttctgcgtgttgcc	CRISPR spacer
acggccctgaccctggttctacgcggcgtt	Protospacer
 .******************.**.* .*..

29. spacer 7.3|4931319|30|NZ_CP049838|CRT matches to NZ_CP022762 (Ralstonia solanacearum strain T95 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

ctggccctgaccctggttctgcgtgttgcc	CRISPR spacer
acggccctgaccctggttctacgcggcgtt	Protospacer
 .******************.**.* .*..

30. spacer 7.3|4931319|30|NZ_CP049838|CRT matches to NZ_CP023017 (Ralstonia solanacearum strain SL3022 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

ctggccctgaccctggttctgcgtgttgcc	CRISPR spacer
acggccctgaccctggttctacgcggcgtt	Protospacer
 .******************.**.* .*..

31. spacer 7.3|4931319|30|NZ_CP049838|CRT matches to NZ_CP014703 (Ralstonia solanacearum strain KACC 10722 plasmid, complete sequence) position: , mismatch: 8, identity: 0.733

ctggccctgaccctggttctgcgtgttgcc	CRISPR spacer
acggccctgaccctggttctacgcggcgtt	Protospacer
 .******************.**.* .*..

32. spacer 7.3|4931319|30|NZ_CP049838|CRT matches to NZ_CP022760 (Ralstonia solanacearum strain T98 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

ctggccctgaccctggttctgcgtgttgcc	CRISPR spacer
acggccctgaccctggttctacgcggcgtt	Protospacer
 .******************.**.* .*..

33. spacer 7.3|4931319|30|NZ_CP049838|CRT matches to NZ_CP022789 (Ralstonia solanacearum strain SL3175 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

ctggccctgaccctggttctgcgtgttgcc	CRISPR spacer
acggccctgaccctggttctacgcggcgtt	Protospacer
 .******************.**.* .*..

34. spacer 7.3|4931319|30|NZ_CP049838|CRT matches to NZ_CP022771 (Ralstonia solanacearum strain T51 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

ctggccctgaccctggttctgcgtgttgcc	CRISPR spacer
acggccctgaccctggttctacgcggcgtt	Protospacer
 .******************.**.* .*..

35. spacer 7.3|4931319|30|NZ_CP049838|CRT matches to NZ_CP022777 (Ralstonia solanacearum strain T11 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

ctggccctgaccctggttctgcgtgttgcc	CRISPR spacer
acggccctgaccctggttctacgcggcgtt	Protospacer
 .******************.**.* .*..

36. spacer 7.3|4931319|30|NZ_CP049838|CRT matches to NZ_CP022799 (Ralstonia solanacearum strain SL2064 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

ctggccctgaccctggttctgcgtgttgcc	CRISPR spacer
acggccctgaccctggttctacgcggcgtt	Protospacer
 .******************.**.* .*..

37. spacer 7.3|4931319|30|NZ_CP049838|CRT matches to NZ_CP022764 (Ralstonia solanacearum strain T82 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

ctggccctgaccctggttctgcgtgttgcc	CRISPR spacer
acggccctgaccctggttctacgcggcgtt	Protospacer
 .******************.**.* .*..

38. spacer 7.3|4931319|30|NZ_CP049838|CRT matches to NZ_CP022797 (Ralstonia solanacearum strain SL2312 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

ctggccctgaccctggttctgcgtgttgcc	CRISPR spacer
acggccctgaccctggttctacgcggcgtt	Protospacer
 .******************.**.* .*..

39. spacer 7.3|4931319|30|NZ_CP049838|CRT matches to NZ_CP022758 (Ralstonia solanacearum strain T101 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

ctggccctgaccctggttctgcgtgttgcc	CRISPR spacer
acggccctgaccctggttctacgcggcgtt	Protospacer
 .******************.**.* .*..

40. spacer 17.2|6550163|38|NZ_CP049838|PILER-CR matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 8, identity: 0.789

gcttcggccgtgtcgacggcggcttcggccggggccgc	CRISPR spacer
gcttcggccgtgccgacggcggcgtcgcgcttgacctc	Protospacer
************.********** ***  *  *.** *

41. spacer 7.2|4931265|33|NZ_CP049838|CRT matches to MT986029 (Gordonia phage Linetti, complete genome) position: , mismatch: 9, identity: 0.727

gggcatgcccccgccggggaagccgccggtgcc	CRISPR spacer
agcaccgccgccgccggggaagctgccggttgc	Protospacer
.*   .*** *************.******  *

42. spacer 1.1|2246741|31|NZ_CP049838|CRISPRCasFinder matches to NZ_CP023524 (Burkholderia gladioli pv. gladioli strain FDAARGOS_389 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.677

tctcggcagcggcgcatccacccagcccgtc	CRISPR spacer
ctcgaagcgcggcgcatccacccaggccatc	Protospacer
... ..  ***************** **.**

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

224968 : 267173

Mycobacterium_phage(100.0%)

integrase,protease,transposase

attL 232337:232353|attR 263400:263416

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_171401765.1\|224968_225808_-\|transposase	transposase	NA	NA	NA	NA
WP_171401766.1\|226588_227560_-	aldo/keto reductase	NA	NA	NA	NA
WP_171394752.1\|227708_228314_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_171394753.1\|228515_228908_+	ester cyclase	NA	NA	NA	NA
WP_171394754.1\|228900_229998_+	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_171394755.1\|230175_231123_+\|integrase	site-specific integrase	NA	NA	NA	NA
232337:232353	attL	NA	NA	NA	NA
WP_171401767.1\|232463_233594_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_171394756.1\|233590_234106_+	hypothetical protein	NA	NA	NA	NA
WP_123995091.1\|234597_234948_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_171394757.1\|235036_235504_+	ester cyclase	NA	NA	NA	NA
WP_171394758.1\|236114_237212_-	NmrA family NAD(P)-binding protein	NA	NA	NA	NA
WP_171394759.1\|237635_238205_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_171394760.1\|238351_238723_-	DUF1330 domain-containing protein	NA	NA	NA	NA
WP_171394761.1\|238957_239836_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_171394762.1\|239864_240566_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_171394763.1\|240654_241098_-	hypothetical protein	NA	NA	NA	NA
WP_171401768.1\|241558_243058_+	MFS transporter	A0A0M3UL24	Mycobacterium_phage	2.7e-55	35.2
WP_171394764.1\|243363_243933_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_171394765.1\|244243_245368_+	4Fe-4S binding protein	NA	NA	NA	NA
WP_171394766.1\|245644_246214_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_171394767.1\|246239_246764_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_171394768.1\|247871_248730_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_171394769.1\|248745_249303_-	SMI1/KNR4 family protein	NA	NA	NA	NA
WP_171394770.1\|249474_250335_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_171401769.1\|250341_250719_-	hypothetical protein	NA	NA	NA	NA
WP_171394771.1\|250766_251015_-	hypothetical protein	NA	NA	NA	NA
WP_171394772.1\|251057_252554_-\|transposase	transposase	NA	NA	NA	NA
WP_171394773.1\|253021_253336_+	hypothetical protein	NA	NA	NA	NA
WP_171394774.1\|253350_257994_+\|protease	serine protease	NA	NA	NA	NA
WP_171394775.1\|259277_260085_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_171394776.1\|260117_261110_-	aldo/keto reductase	NA	NA	NA	NA
WP_171394777.1\|261236_261866_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_171394778.1\|262869_264180_-	MFS transporter	NA	NA	NA	NA
263400:263416	attR	NA	NA	NA	NA
WP_171394779.1\|264225_264837_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_171394780.1\|265974_266616_+	hypothetical protein	NA	NA	NA	NA
WP_171394781.1\|266648_267173_-\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_2

5239522 : 5303868

Catovirus(22.22%)

plate,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_171398385.1\|5239522_5240080_-\|tail	phage tail protein	NA	NA	NA	NA
WP_171398386.1\|5240111_5242070_-\|plate	putative baseplate assembly protein	NA	NA	NA	NA
WP_171398387.1\|5242069_5242513_-	GPW/gp25 family protein	A0A0E3EVV0	Synechococcus_phage	8.2e-13	32.7
WP_171398388.1\|5242562_5244464_-	VgrG-related protein	NA	NA	NA	NA
WP_171398389.1\|5244463_5245189_-	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_020132884.1\|5245244_5245670_-\|tail	phage tail protein	NA	NA	NA	NA
WP_171402131.1\|5245727_5246339_-	extensin	NA	NA	NA	NA
WP_171398390.1\|5246790_5248563_+	hypothetical protein	NA	NA	NA	NA
WP_171398391.1\|5249600_5249759_-	hypothetical protein	NA	NA	NA	NA
WP_020132886.1\|5249755_5250280_-	hypothetical protein	NA	NA	NA	NA
WP_020132887.1\|5250279_5250723_-\|tail	phage tail protein	NA	NA	NA	NA
WP_171398392.1\|5250784_5252377_-\|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	3.2e-67	34.9
WP_171398393.1\|5252690_5254115_+	hydrolase	NA	NA	NA	NA
WP_171398394.1\|5254244_5255630_+	ricin-type beta-trefoil lectin domain protein	NA	NA	NA	NA
WP_171402132.1\|5257137_5259135_-	ATP-binding protein	A0A0R6PCP6	Moraxella_phage	4.4e-21	31.2
WP_171398395.1\|5259485_5260160_-	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_171398396.1\|5260299_5260959_-	response regulator transcription factor	NA	NA	NA	NA
WP_171398397.1\|5261307_5264265_+	AAA family ATPase	NA	NA	NA	NA
WP_171398398.1\|5264707_5265070_+	hypothetical protein	NA	NA	NA	NA
WP_171398399.1\|5265126_5265339_+	DUF4287 domain-containing protein	NA	NA	NA	NA
WP_171398400.1\|5265364_5266873_-	DEAD/DEAH box helicase	A0A1V0SBR7	Catovirus	1.1e-35	27.1
WP_020133270.1\|5267004_5267208_-	cold-shock protein	A0A1X9IGI9	Lactococcus_phage	1.2e-16	61.2
WP_171402133.1\|5267576_5267870_+	hypothetical protein	NA	NA	NA	NA
WP_171398401.1\|5267892_5268255_+	DUF952 domain-containing protein	NA	NA	NA	NA
WP_171398402.1\|5268368_5271404_+	M4 family metallopeptidase	NA	NA	NA	NA
WP_171398403.1\|5271470_5271926_-	TerB family tellurite resistance protein	NA	NA	NA	NA
WP_171398404.1\|5272201_5273131_-	hypothetical protein	NA	NA	NA	NA
WP_171398405.1\|5273393_5274977_+	carbohydrate-binding protein	NA	NA	NA	NA
WP_171398406.1\|5275049_5275508_-	TIGR03618 family F420-dependent PPOX class oxidoreductase	NA	NA	NA	NA
WP_171398407.1\|5275626_5275911_+	hypothetical protein	NA	NA	NA	NA
WP_171398408.1\|5275886_5276432_+	hypothetical protein	NA	NA	NA	NA
WP_171398409.1\|5276494_5277154_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_171398410.1\|5277305_5278337_+	zinc-binding dehydrogenase	NA	NA	NA	NA
WP_171398411.1\|5278506_5279154_+	SRPBCC family protein	NA	NA	NA	NA
WP_171398412.1\|5279272_5279980_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_171398413.1\|5279976_5281074_+	CU044_5270 family protein	NA	NA	NA	NA
WP_171398414.1\|5281087_5281537_-	hypothetical protein	NA	NA	NA	NA
WP_171398415.1\|5281786_5284120_+	histidine kinase	NA	NA	NA	NA
WP_171398416.1\|5284116_5284800_+	response regulator transcription factor	NA	NA	NA	NA
WP_171398417.1\|5284927_5285278_+	hypothetical protein	NA	NA	NA	NA
WP_171398418.1\|5285280_5285619_-	MerR family transcriptional regulator	NA	NA	NA	NA
WP_171398419.1\|5286070_5286385_-	hypothetical protein	NA	NA	NA	NA
WP_171398420.1\|5286391_5286679_-	CBS domain-containing protein	NA	NA	NA	NA
WP_171398421.1\|5286734_5288219_-	DEAD/DEAH box helicase	A0A1V0SBR7	Catovirus	8.8e-35	26.4
WP_020133169.1\|5288436_5288640_-	cold-shock protein	A0A1X9IGI9	Lactococcus_phage	1.0e-15	61.2
WP_171398422.1\|5288950_5289937_-	polysaccharide deacetylase family protein	NA	NA	NA	NA
WP_171398423.1\|5289974_5290946_-	glycoside hydrolase family 11 protein	NA	NA	NA	NA
WP_171402134.1\|5291231_5292377_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_171398424.1\|5292544_5293324_-	sugar ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	6.5e-13	24.9
WP_171398425.1\|5293358_5294480_-	substrate-binding domain-containing protein	NA	NA	NA	NA
WP_171402135.1\|5294553_5295033_-	monooxygenase	NA	NA	NA	NA
WP_171398426.1\|5295155_5296010_+	polysaccharide deacetylase family protein	NA	NA	NA	NA
WP_171398427.1\|5295978_5296311_-	hypothetical protein	NA	NA	NA	NA
WP_171398428.1\|5296612_5297284_+	response regulator transcription factor	NA	NA	NA	NA
WP_171398429.1\|5297238_5297940_-	response regulator transcription factor	NA	NA	NA	NA
WP_171398430.1\|5297941_5299267_-	sensor domain-containing protein	NA	NA	NA	NA
WP_171398431.1\|5299505_5299715_+	hypothetical protein	NA	NA	NA	NA
WP_171398432.1\|5299711_5300431_+	ABC transporter ATP-binding protein	W5SAS9	Pithovirus	1.6e-18	32.5
WP_171398433.1\|5300434_5302969_+	ABC transporter permease	NA	NA	NA	NA
WP_171398434.1\|5303334_5303868_+\|tail	lamin tail domain-containing protein	NA	NA	NA	NA

DBSCAN-SWA_3

5962430 : 5982988

Streptomyces_phage(76.92%)

tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_020132669.1\|5962430_5965916_+	DNA-directed RNA polymerase subunit beta	G8DH04	Emiliania_huxleyi_virus	3.6e-31	22.0
WP_171398903.1\|5966013_5969913_+	DNA-directed RNA polymerase subunit beta'	A0A2I7QNZ7	Vibrio_phage	1.1e-55	27.3
WP_054238759.1\|5970010_5970271_-	hypothetical protein	A0A1J0MCA5	Streptomyces_phage	5.3e-28	80.2
WP_171398904.1\|5970267_5970528_-	hypothetical protein	A0A142K647	Streptomyces_phage	1.6e-16	65.2
WP_171398905.1\|5970543_5971443_-	N-acetylmuramoyl-L-alanine amidase	A0A2P1N078	Streptomyces_phage	6.8e-91	60.4
WP_171398906.1\|5972133_5972874_-	hypothetical protein	A0A1J0MC40	Streptomyces_phage	5.7e-27	34.7
WP_171398907.1\|5972873_5974019_-	hypothetical protein	A0A1J0MCX4	Streptomyces_phage	1.9e-85	45.5
WP_171398908.1\|5974055_5975078_-	hypothetical protein	A0A1V0E646	Streptomyces_phage	9.9e-70	47.1
WP_171398909.1\|5975121_5976309_-	hypothetical protein	A0A1J0MCA6	Streptomyces_phage	2.7e-47	47.3
WP_171398910.1\|5976335_5977550_-	hypothetical protein	A0A1J0MCA6	Streptomyces_phage	2.9e-52	50.5
WP_171398911.1\|5977623_5978940_-	hypothetical protein	A0A2H5BLD9	Streptomyces_phage	4.9e-45	49.3
WP_171398912.1\|5978944_5979865_-\|tail	phage tail family protein	A0A1J0MCF9	Streptomyces_phage	9.2e-51	42.6
WP_171398913.1\|5980517_5981798_-	tape-measure protein	NA	NA	NA	NA
WP_171398914.1\|5981794_5982988_-\|tail	phage tail protein	F8UBM9	Clostridium_phage	1.5e-05	44.3

DBSCAN-SWA_4

7114407 : 7124012

Streptomyces_phage(62.5%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_171399733.1\|7114407_7116234_-	AAA family ATPase	Q1WDH9	Streptomyces_phage	1.3e-136	48.9
WP_171399734.1\|7116245_7116554_-	hypothetical protein	NA	NA	NA	NA
WP_171399735.1\|7116550_7117360_-	DUF2303 family protein	I6NVL7	Burkholderia_virus	2.2e-16	30.3
WP_171399736.1\|7117362_7117743_-	hypothetical protein	NA	NA	NA	NA
WP_171399737.1\|7117878_7118025_-	hypothetical protein	NA	NA	NA	NA
WP_171399738.1\|7118021_7118357_-	WhiB family transcriptional regulator	A0A222ZPZ4	Mycobacterium_phage	1.7e-07	57.1
WP_171399739.1\|7118353_7119259_-	hypothetical protein	A0A0M4QTU3	Streptomyces_phage	8.4e-81	51.5
WP_171399740.1\|7119258_7119879_-	hypothetical protein	Q1WDI4	Streptomyces_phage	1.1e-34	48.5
WP_171399741.1\|7119875_7120013_-	hypothetical protein	NA	NA	NA	NA
WP_171399742.1\|7120009_7120843_-	DNA polymerase III subunit epsilon	A0A0M3UK53	Streptomyces_phage	1.8e-53	42.4
WP_171402259.1\|7120839_7121472_-	ERF family protein	A0A0M4RQK0	Mycobacterium_phage	7.3e-23	41.9
WP_171399743.1\|7121623_7122661_-	YqaJ viral recombinase family protein	NA	NA	NA	NA
WP_171399744.1\|7122657_7122885_-	hypothetical protein	NA	NA	NA	NA
WP_171399745.1\|7122881_7123115_-	hypothetical protein	NA	NA	NA	NA
WP_171399746.1\|7123107_7123569_-	hypothetical protein	NA	NA	NA	NA
WP_171399747.1\|7123565_7124012_-	hypothetical protein	Q6VY85	Streptomyces_phage	4.7e-24	45.7

Anti-CRISPR protein detection

Acr_ID: NZ_CP049838.1|WP_171398398.1|5264707_5265070_+|hypothetical-protein

Click the colored protein region to show detailed information

Acr_ID: NZ_CP049838.1|WP_171398413.1|5279976_5281074_+|CU044_5270-family-protein

Click the colored protein region to show detailed information

Acr_ID: NZ_CP049838.1|WP_171398414.1|5281087_5281537_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr_ID: NZ_CP049838.1|WP_171402135.1|5294553_5295033_-|monooxygenase

Click the colored protein region to show detailed information

Acr_ID: NZ_CP049838.1|WP_171398427.1|5295978_5296311_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr_ID: NZ_CP049838.1|WP_171398431.1|5299505_5299715_+|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_CP049838.1|WP_171398398.1|5264707_5265070_+|hypothetical-protein

5264707_5265070_+

120 aa aa

HTH_LUXR

Identity	Hit_domain_coverage
0.48214285714285715	0.9655172413793104

5239522-5303868

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP049838_10	Orphan	10.2\|5259222\|66\|NZ_CP049838\|PILER-CR	5259222-5259287	66	5259369-5259434	6

1. spacer 10.2|5259222|66|NZ_CP049838|PILER-CR matches to NZ_CP049838 position: 5259369-5259434, mismatch: 6

tcacgggcgccccggtggcggctgccgaagcaccggatccccgatgtgtcccatgcccca	CRISPR spacer
tcacgggcgccccggtggcggctgccgaagcaccggatccccgatgtgtcccatgcccca	Protospacer
************************************************************

NZ_CP049838.1|WP_171398413.1|5279976_5281074_+|CU044_5270-family-protein

5279976_5281074_+

365 aa aa

HTH_LUXR

Identity	Hit_domain_coverage
0.5862068965517241	1.0

5239522-5303868

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP049838_10	Orphan	10.2\|5259222\|66\|NZ_CP049838\|PILER-CR	5259222-5259287	66	5259369-5259434	6

1. spacer 10.2|5259222|66|NZ_CP049838|PILER-CR matches to NZ_CP049838 position: 5259369-5259434, mismatch: 6

tcacgggcgccccggtggcggctgccgaagcaccggatccccgatgtgtcccatgcccca	CRISPR spacer
tcacgggcgccccggtggcggctgccgaagcaccggatccccgatgtgtcccatgcccca	Protospacer
************************************************************

NZ_CP049838.1|WP_171398414.1|5281087_5281537_-|hypothetical-protein

5281087_5281537_-

149 aa aa

HTH_LUXR

Identity	Hit_domain_coverage
0.5862068965517241	1.0

5239522-5303868

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP049838_10	Orphan	10.2\|5259222\|66\|NZ_CP049838\|PILER-CR	5259222-5259287	66	5259369-5259434	6

1. spacer 10.2|5259222|66|NZ_CP049838|PILER-CR matches to NZ_CP049838 position: 5259369-5259434, mismatch: 6

tcacgggcgccccggtggcggctgccgaagcaccggatccccgatgtgtcccatgcccca	CRISPR spacer
tcacgggcgccccggtggcggctgccgaagcaccggatccccgatgtgtcccatgcccca	Protospacer
************************************************************

NZ_CP049838.1|WP_171402135.1|5294553_5295033_-|monooxygenase

5294553_5295033_-

159 aa aa

HTH_LUXR

Identity	Hit_domain_coverage
0.5689655172413793	1.0

5239522-5303868

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP049838_10	Orphan	10.2\|5259222\|66\|NZ_CP049838\|PILER-CR	5259222-5259287	66	5259369-5259434	6

1. spacer 10.2|5259222|66|NZ_CP049838|PILER-CR matches to NZ_CP049838 position: 5259369-5259434, mismatch: 6

tcacgggcgccccggtggcggctgccgaagcaccggatccccgatgtgtcccatgcccca	CRISPR spacer
tcacgggcgccccggtggcggctgccgaagcaccggatccccgatgtgtcccatgcccca	Protospacer
************************************************************

NZ_CP049838.1|WP_171398427.1|5295978_5296311_-|hypothetical-protein

5295978_5296311_-

110 aa aa

HTH_LUXR

Identity	Hit_domain_coverage
0.5689655172413793	1.0

5239522-5303868

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP049838_10	Orphan	10.2\|5259222\|66\|NZ_CP049838\|PILER-CR	5259222-5259287	66	5259369-5259434	6

1. spacer 10.2|5259222|66|NZ_CP049838|PILER-CR matches to NZ_CP049838 position: 5259369-5259434, mismatch: 6

tcacgggcgccccggtggcggctgccgaagcaccggatccccgatgtgtcccatgcccca	CRISPR spacer
tcacgggcgccccggtggcggctgccgaagcaccggatccccgatgtgtcccatgcccca	Protospacer
************************************************************

NZ_CP049838.1|WP_171398431.1|5299505_5299715_+|hypothetical-protein

5299505_5299715_+

69 aa aa

HTH_LUXR

Identity	Hit_domain_coverage
0.46938775510204084	0.8448275862068966

5239522-5303868

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP049838_10	Orphan	10.2\|5259222\|66\|NZ_CP049838\|PILER-CR	5259222-5259287	66	5259369-5259434	6

1. spacer 10.2|5259222|66|NZ_CP049838|PILER-CR matches to NZ_CP049838 position: 5259369-5259434, mismatch: 6

tcacgggcgccccggtggcggctgccgaagcaccggatccccgatgtgtcccatgcccca	CRISPR spacer
tcacgggcgccccggtggcggctgccgaagcaccggatccccgatgtgtcccatgcccca	Protospacer
************************************************************

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP049838

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information