CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number
NZ_CP053565	Pseudonocardia sp. Gen01 plasmid unnamed1, complete sequence	0 crisprs	csa3	0	0	0
NZ_CP053566	Pseudonocardia sp. Gen01 plasmid unnamed2, complete sequence	0 crisprs	NA	0	0	0
NZ_CP053567	Pseudonocardia sp. Gen01 plasmid unnamed3, complete sequence	0 crisprs	NA	0	0	3
NZ_CP053564	Pseudonocardia sp. Gen01 chromosome, complete genome	12 crisprs	csa3,DinG,WYL,cas3,RT,cas4,DEDDh	1	11	2

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 5872

Arthrobacter_phage(33.33%)

terminase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_172170111.1\|313_520_-	hypothetical protein	NA	NA	NA	NA
WP_172170216.1\|531_1971_-\|terminase	terminase	A0A0U4JKK7	Arthrobacter_phage	1.3e-83	39.1
WP_172170114.1\|2125_2467_-	hypothetical protein	NA	NA	NA	NA
WP_172170117.1\|2731_3004_-	hypothetical protein	NA	NA	NA	NA
WP_172170120.1\|3416_4958_-	NTP-binding protein	A0A060D5T9	Salmonella_phage	6.1e-55	37.5
WP_172170123.1\|4957_5872_-	bifunctional DNA primase/polymerase	A0A0K1LKD4	Vibrio_phage	9.0e-22	31.1

DBSCAN-SWA_2

13280 : 13961

Mycobacterium_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_172170153.1\|13280_13961_-	AAA family ATPase	A0A222ZPP5	Mycobacterium_phage	1.3e-06	30.1

DBSCAN-SWA_3

17041 : 26293

Streptomyces_phage(40.0%)

capsid,head,protease,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_172170177.1\|17041_19885_-	hypothetical protein	A0A142K644	Streptomyces_phage	8.9e-44	29.4
WP_172170180.1\|19888_21235_-	hypothetical protein	A0A2R4A0Z4	Microbacterium_phage	1.1e-07	49.3
WP_172170219.1\|21234_21633_-	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_172170183.1\|21658_21835_-	hypothetical protein	NA	NA	NA	NA
WP_172170186.1\|21815_22169_-	hypothetical protein	NA	NA	NA	NA
WP_172170189.1\|22201_22609_-	hypothetical protein	NA	NA	NA	NA
WP_172170192.1\|22610_22997_-	hypothetical protein	NA	NA	NA	NA
WP_172170195.1\|23011_23644_-\|head,tail	phage gp6-like head-tail connector protein	NA	NA	NA	NA
WP_172170198.1\|23656_23983_-	hypothetical protein	A0A142K639	Streptomyces_phage	1.4e-06	38.5
WP_172170201.1\|23982_24168_-	hypothetical protein	NA	NA	NA	NA
WP_172170204.1\|24171_25467_-\|capsid	phage major capsid protein	A0A142F2E2	Mycobacterium_phage	2.7e-16	27.4
WP_172170207.1\|25693_26293_-\|head,protease	HK97 family phage prohead protease	A0A2R4A075	Microbacterium_phage	1.4e-07	37.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP053564

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP053564_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053564_1

1530986-1531482

Orphan

Consensus_repeat	Method
NCANGGCTACGGCCAGCAG	CRT

8 spacers

The CRISPR arrays of NZ_CP053564_1

>merge|NZ_CP053564|1|1530986-1531482|CRT
GGCGGATACGGGCAGCAGACGTACGCCCCGCCCGCCTACGACCAGCGCCAGGGGGGGTACGACCAGGGCGAGCAGCCCCCGCAGGGCTACGGCCAGCAGCCGGGCTACGGCCAGCCGGGCTACGGCCAGCAGGGCGGCGCCCCCGACCCCTACGGCCAGCAGGGCTACGGCCAGCCCCAGCAGGGTGGCTACGGCCAGCAGCCCGGGTACGACCAGGGCTACGGCCAGCAGCAGCCCGGCTACGACCAGGGCTACGGGCAGCAGCAGCCCGGCTACGGCCAGCCCGGCTACGGGCAGCAGCCCGGGTACGACCAGGGCTACGGCCAGCAGCAGCCCGGCTACGGCCAGCAGGGCTACGACCAGGGTTACGGCCAGCAGCAGGGCTACGGCCAGCAGGGCTACGACCAGGGCTACGGCCAGCAGGGCTACGGGCAGCAGGGGTACGGCCAGCAGGGCTACTCCGCCACGCTGAGCCTCGACGACGGCTCGGGCCGCAA

>NZ_CP053564|1|1|1530986-1531482|CRT
GGCGGATACGGGCAGCAG	ACGTACGCCCCGCCCGCCTACGACCAGCGCCAGGGGGGGTACGACCAGGGCGAGCAGCCCCCG
CAGGGCTACGGCCAGCAG	CCGGGCTACGGCCAGCCGGGCTACGGCCAGCAGGGCGGCGCCCCCGACCCCTACGGCCAG
CAGGGCTACGGCCAGCCC	CAGCAGGGTGGCTACGGCCAGCAGCCCGGGTACGAC
CAGGGCTACGGCCAGCAG	CAGCCCGGCTACGACCAGGGCTACGGGCAGCAGCAG
CCCGGCTACGGCCAGCCC	GGCTACGGGCAGCAGCCCGGGTACGAC
CAGGGCTACGGCCAGCAG	CAGCCCGGCTACGGCCAGCAGGGCTACGACCAGGGTTACGGCCAGCAG
CAGGGCTACGGCCAGCAG	GGCTACGACCAGGGCTACGGCCAG
CAGGGCTACGGGCAGCAG	GGGTACGGCCAGCAGGGCTACTCCGCCACGCTGAGCCTCGA
CGACGGCTCGGGCCGCAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053564.1\|WP_172156030.1\|1523326_1524019_+\|haloacid-dehalogenase-type-II	unknown	unknown	gnl\|CDD\|319787
NZ_CP053564.1\|WP_172156053.1\|1531759_1532224_+\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|224630
NZ_CP053564.1\|WP_172156075.1\|1540580_1540850_+\|cell-division-protein-CrgA	unknown	unknown	gnl\|CDD\|178907
NZ_CP053564.1\|WP_172156032.1\|1524168_1524645_+\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|224991
NZ_CP053564.1\|WP_172156062.1\|1537912_1539835_+\|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP053564.1\|WP_172156038.1\|1526585_1527428_+\|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274680
NZ_CP053564.1\|WP_172156036.1\|1525404_1526538_-\|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|180601
NZ_CP053564.1\|WP_172156089.1\|1541344_1542205_-\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|366759
NZ_CP053564.1\|WP_172156055.1\|1532270_1533602_+\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|223704
NZ_CP053564.1\|WP_172156077.1\|1540912_1541359_+\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|371225
NZ_CP053564.1\|WP_172156047.1\|1529322_1529565_+\|DUF2630-family-protein	unknown	unknown	gnl\|CDD\|378515
NZ_CP053564.1\|WP_172156034.1\|1524661_1525408_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|369777
NZ_CP053564.1\|WP_172156049.1\|1529570_1530185_+\|uridine-kinase	unknown	unknown	gnl\|CDD\|180660
NZ_CP053564.1\|WP_172156060.1\|1535021_1536497_+\|penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|223839
NZ_CP053564.1\|WP_172156045.1\|1529000_1529303_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053564.1\|WP_172156041.1\|1527475_1528264_-\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_CP053564.1\|WP_172168034.1\|1536582_1537806_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP053564.1\|WP_172156064.1\|1539862_1540498_+\|aminodeoxychorismate/anthranilate-synthase-component-II	unknown	unknown	gnl\|CDD\|181107
NZ_CP053564.1\|WP_172156057.1\|1533603_1535025_+\|FtsW/RodA/SpoVE-family-cell-cycle-protein	unknown	unknown	gnl\|CDD\|223843
NZ_CP053564.1\|WP_172156043.1\|1528283_1528940_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102

Protein	Function_ID	Function_description	E-value
NZ_CP053564.1\|WP_172156030.1\|1523326_1524019_+\|haloacid-dehalogenase-type-II	gnl\|CDD\|319787	cd02588, HAD_L2-DEX, L-2-haloacid dehalogenase. L-2-Haloacid dehalogenase catalyzes the hydrolytic dehalogenation of L-2-haloacids to produce the corresponding D-2-hydroxyacids with an inversion of the C2-configuration. 2-haloacid dehalogenases are of interest for their potential to degrade recalcitrant halogenated environmental pollutants and their use in the synthesis of industrial chemicals. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	6.17648e-61
NZ_CP053564.1\|WP_172156053.1\|1531759_1532224_+\|FHA-domain-containing-protein	gnl\|CDD\|224630	COG1716, COG1716, FOG: FHA domain [Signal transduction mechanisms].	1.20525e-20
NZ_CP053564.1\|WP_172156075.1\|1540580_1540850_+\|cell-division-protein-CrgA	gnl\|CDD\|178907	PRK00159, PRK00159, putative septation inhibitor protein; Reviewed.	6.9196e-40
NZ_CP053564.1\|WP_172156032.1\|1524168_1524645_+\|(2Fe-2S)-binding-protein	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	1.18905e-56
NZ_CP053564.1\|WP_172156062.1\|1537912_1539835_+\|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.70565e-125
NZ_CP053564.1\|WP_172156038.1\|1526585_1527428_+\|LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|274680	TIGR03619, F420_Rv2161c, probable F420-dependent oxidoreductase, Rv2161c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity].	3.81869e-84
NZ_CP053564.1\|WP_172156036.1\|1525404_1526538_-\|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase	gnl\|CDD\|180601	PRK06520, PRK06520, 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.	1.15578e-158
NZ_CP053564.1\|WP_172156089.1\|1541344_1542205_-\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|366759	pfam01694, Rhomboid, Rhomboid family. This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.	3.94865e-31
NZ_CP053564.1\|WP_172156055.1\|1532270_1533602_+\|serine/threonine-protein-phosphatase	gnl\|CDD\|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	2.80678e-77
NZ_CP053564.1\|WP_172156077.1\|1540912_1541359_+\|PH-domain-containing-protein	gnl\|CDD\|371225	pfam10756, bPH_6, Bacterial PH domain. This domain has a bacterial type PH domain structure. This domain was previously known as DUF2581. This family is conserved in the Actinomycetales. Although several members are annotated as RbiX homologs, RbiX being a putative regulator of riboflavin biosynthesis, the function could not be confirmed.	7.10172e-06
NZ_CP053564.1\|WP_172156047.1\|1529322_1529565_+\|DUF2630-family-protein	gnl\|CDD\|378515	pfam10944, DUF2630, Protein of unknown function (DUF2630). This bacterial family of proteins have no known function.	2.11507e-23
NZ_CP053564.1\|WP_172156034.1\|1524661_1525408_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	1.08921e-12
NZ_CP053564.1\|WP_172156049.1\|1529570_1530185_+\|uridine-kinase	gnl\|CDD\|180660	PRK06696, PRK06696, uridine kinase; Validated.	2.18916e-12
NZ_CP053564.1\|WP_172156060.1\|1535021_1536497_+\|penicillin-binding-protein-2	gnl\|CDD\|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	8.76513e-93
NZ_CP053564.1\|WP_172156041.1\|1527475_1528264_-\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	2.0432e-41
NZ_CP053564.1\|WP_172168034.1\|1536582_1537806_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.85011e-101
NZ_CP053564.1\|WP_172156064.1\|1539862_1540498_+\|aminodeoxychorismate/anthranilate-synthase-component-II	gnl\|CDD\|181107	PRK07765, PRK07765, aminodeoxychorismate/anthranilate synthase component II.	2.33902e-124
NZ_CP053564.1\|WP_172156057.1\|1533603_1535025_+\|FtsW/RodA/SpoVE-family-cell-cycle-protein	gnl\|CDD\|223843	COG0772, FtsW, Bacterial cell division membrane protein [Cell division and chromosome partitioning].	1.06969e-84
NZ_CP053564.1\|WP_172156043.1\|1528283_1528940_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	9.2746e-08

>NZ_CP053564.1|WP_172156049.1|1529570_1530185_+|uridine-kinase
MQVTPLTPERLADEVVGLVAARPGRVRLAVDGPPPTRPEALAARVAEDLRTLGREAVVVAAADFLRPASVRLEHGREDPDELLDGWLDAGGLRREVLDPAASTGRVLPRLWDAAADRAFRDGYAQLPPDGVVVVAGALLLGRGLPFDLAVHLHMGAAALARRTPDDERWTLPAHARYAAERDPAGRADLVVLADHPDRPAVRRT
>NZ_CP053564.1|WP_172156047.1|1529322_1529565_+|DUF2630-family-protein
MDDDTLHRRIDELVAEEHRLERSHIGTALSPEEKDRLDRLGIQLDRYWDLLRQRDARRRAGQDPDGAQERDAGTVEGYRQ
>NZ_CP053564.1|WP_172156045.1|1529000_1529303_+|hypothetical-protein
MVYAFTQDVPIDAGLYRRIVDELGPEPIDGQLLHLCVRREDGGLRYIDVWESAEHCARAFDERIHPAVERAFGGARPSGEPVVHHLDVLDATGLLLQAPR
>NZ_CP053564.1|WP_172156043.1|1528283_1528940_-|TetR/AcrR-family-transcriptional-regulator
MGDDVKGRRGYRAPRRAEQAAGTRRAVLDAARALFLAQGYSATTVAQIAERAGVNVDTLYASVGRKPVLLREVVETAISGTDRAVPAEERDYVRAVRAAPTARAGIALYAAAVAEMGPRTAPVFSALRDAAARDPQCARLRTEITQRRAANMRLFAADLRATGELRPDLTDDEVADIVWSTGSAEYYVLLVQERGWTTERFGEHLADLWSRMLLAPGA
>NZ_CP053564.1|WP_172156041.1|1527475_1528264_-|IclR-family-transcriptional-regulator
MEPERSTGTSITRALRVVEAVAAAGDGVTAKAIARRLACPLPTVYRALGTLVQEGYLVRLQESRGYGLGYRIAELHRSLADQVRPPSPVRAVLHELHENLGATAHLVVFRDTDIVVAAVDDCADHPRPDGFDVGEPTPAHATAGGKVLLAPLRPARVSELIAPYGMPRLTSRTLVERRGLDRELMRVRSAGVAVEVEEYRAGTAGVAAPVTGPGGAVRSAIGVTVSRAEFTARRWELEVAVREAAGRVARAESDDVRAAGGH
>NZ_CP053564.1|WP_172156038.1|1526585_1527428_+|LLM-class-F420-dependent-oxidoreductase
MDFGVVTFLTDYGPAPVELGRAVEERGFGALMLTEHTHIPTSRESPWPGGPELPARYSHTYDPFVALAAIAATTDRIALGTAVSLVAQHDPIVLAKAVASLDRIAGGRVELGIGPGWNAEEMANHGVDPARRTARMLEHVEAMKAIWTHDEAEYHGTFVDFDPIWSWPKPTRLPPVLIGGGGPTVLDRVLSHGDGWIPLRVPVSGLDEFGGRVAELQRRAADAGRGHLPVTVYGASPKPQALESYAAAGVDRVLFELTDPGPAETDAVLRELDELAELLP
>NZ_CP053564.1|WP_172156036.1|1525404_1526538_-|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase
MTPPGAVTAPPFRADHVGSLLRPPALLAAREQHAAGSLDDAGLRAAEDAAITDVVRMQEEVGLRAATDGEFRRTSWHMDFIYRLGGITRTDEQIRVRMRNASGEGAFTSAGMAVTERVRLDEPIFADHFRYLADQVTTAVPKLTIPSPSMVYARGGSAVIDRSVYPDLEGFWADLSAAYADEVAALHGLGCRYLQLDDTALAYLNDPAHRAELAAKGDDPETQHLRYIRQINAAIADRPADLRVTTHMCRGNYRSSWAAEGGYDHVAEALFGELAVDGFFCEFDDERSGGFEPLRFVPPGKQVVLGLVTTKSGALEDADALKRRIDEAAKHVPLDQLCLSPQCGFSSTVEGNELTADEQKAKLALIVRVAQDVWGSV
>NZ_CP053564.1|WP_172156034.1|1524661_1525408_-|methyltransferase-domain-containing-protein
MSEGPRGWAAPLYARVLDATGVAAGTRVLDLGSGGGGFAAAAVARGAVVHGIDTDPSAVAVASGEVPDAVFAVGDAHDLGSLGPFDVAAAVQLLAHVVNPVLVLREAARVAPVVAVTVWGREEECDVRAFGEALAPWVGSRRAPDGPPPITEPARLRALVELAGLTVTSFDEVVCPFDYPDDDELVGPLFGTGIGRHAVNRGGPVAVRDAVLERFERHRTPGGGYRLENVFRVLTATSGGATRDGAPA
>NZ_CP053564.1|WP_172156032.1|1524168_1524645_+|(2Fe-2S)-binding-protein
MAQHTFTLNGESVTVEADDDVRLLWVIRDLLGVTGPKYGCGINVCKACTSHINGKAFNPCSVSVADISADDEITTIEGLADTVGSDLHPMQEAWIEKDVAQCGYCQPGQIMAAVAKVRQCADEGRKLDDAAIEEIRNICRCGTYNRIREAIYAGAENM
>NZ_CP053564.1|WP_172156030.1|1523326_1524019_+|haloacid-dehalogenase-type-II
MDVRALVFDVFGTVVDWRSGVAREVARLLGPGVDADAFADAWRGHYLPSMDRVRRGKRPWTGLDGLHRASLDELLEEFGAPATPEAVRVELVHAWHRLDPWPDSVEGLHRLKARHVIATLSNGNVSLLVDMARHGGLPWDTVLSAELFGHYKPDPEVYDGAARLLDVVPGQVLMVAAHLDDLAAARERGLRTAYVHRPDEKGPGVDTASSDPAADLSVGSLVELAERLGC
>NZ_CP053564.1|WP_172156053.1|1531759_1532224_+|FHA-domain-containing-protein
MPELVLQLTRAGFLALLWLFVLVALRVVRSDLYAASGLRSMLPGGGRTAPRGGGRGRMPRQLLVTAGALAGTRVSLEDSRPILIGRADDSTLVLDDDYASTRHARISLQGDEWYVEDLGSTNGTYLDRAKVTGPTRVPLGVPVRIGKTVIELRS
>NZ_CP053564.1|WP_172156055.1|1532270_1533602_+|serine/threonine-protein-phosphatase
MTLVLRYSARSDRGLVRQNNQDAVYAGPRLLALADGMGGHAAGEVASSLVISALAPLDEDDPGDDLLRELREATVEGNAAITRHVREAPDLEGMGTTLTAILFAGSRLGLVHIGDSRAYQLRGGVFTQITKDDTFVQSLIDEGRITEEEAHTHPQRSLLLRAITGQDIDPSLTIREARPGDRYLLCSDGLSGVVSDETLADTLRGYRDPRECADRMIELALRGGGPDNITCIVADVLDIEFGEDAPIVGGAAGDGRDDDGPRPDSAAARASATTLTRPAPQRVAQPAQAPAVARRSRTRIAVAAVAVLAVLVGGALLARIWVLQQYYVGADTDAVAIFQGVQGEVLGVPLHLVAERTEIALDDLPESDRSLVRGGIDAAGLEGAQGVVERLRTKMLEPCPTPTAPAPETALVPTLPDVTYPDYGSTPLPSVPPEPGINCRPVG
>NZ_CP053564.1|WP_172156057.1|1533603_1535025_+|FtsW/RodA/SpoVE-family-cell-cycle-protein
MAAPEAREQAGPPTGRTIELVLLAFAAVLVTGALVLVEANQEQTLTLDLLLIGVAYLALLVAAHIAVRWLAPYADPLILPAVALLNGLGLVMIYRLDLAKADRAVALGNDLPTLLWPRQVAWTGVGLVLFVAVLWIVRDHRKLAAYAYTAGFAGLVLLALPGVLPSSISEVNGAKIWLRLGIFSIQPGEFAKILLIIFFAAFLVQKRDLFSTAGRRFLGMELPRARDLAPLLVAWAFSVGVLVLERDLGTSLLFFGIILVLLYTATERVSWMLIGLAFFAAGGIVAYQLFGHVRTRVQIWLDPFADFDGAGFQIGQALFGLGTGGLGGTGLGAGRPELVPFAESDFMLSSLGEELGLIGLAAVMVIYLVLITRGLRSALAVRDSFGKLLATGLAFTLALQVFIVAGGASKLIPLTGLTLPFLSYGGSSLVANYALVALLLRISNAARAPLPRRPATPLPPIAEAGTELVERPS
>NZ_CP053564.1|WP_172156060.1|1535021_1536497_+|penicillin-binding-protein-2
MNTPVRRIAIAVMAMILLLMANLTYVQVVKAGDYRTDQRNQRVLLAEYSRQRGQISAQGQVLARSVETDGQYPYQREYPNGPAFASVTGYYSLIYSAGGLERAANDVLNGSDDRLFTRRLSDLITGRDPSGGNVVTTIDPAVQQAAYDELSDSGYTGAVVALQPATGAILAMASTPSYDPGPLASQSATTQQDAWAEYTEASPPVLTNRAIQEVYPPGSTFKLIDVAAALESGRYTPDSQLTAASSITLADTATQLQNFNGNQCGTGQTASLRDALQRSCNTAFAELAQQLGEEALRNQAEAFGIGTEDIAIPMTVVPSTIGDIESTAALQQTSIGQRDVALTPMQNAMVVAAIANGGRLMAPYLISEVQGQDLEALDTTAPDQLGQAVSPGVAQTLTEMMVNNENSYQGAGKIRGVQIAAKTGTAEHGADPKSTPPHVWYVAFAPAENPQVAVAVLVESGGDRNNLAATGGAVAAPIGRAVIGAALRGSQ
>NZ_CP053564.1|WP_172168034.1|1536582_1537806_+|serine/threonine-protein-kinase
MGEVWEASDTRLGRSVAVKVLRPELSDDEEFLHRFRIEARTVASLDHTGIAAVHDYGEDDPSDSGRRTAYLVMELVRGEPLSAVIARGPIDTAETLRIIEETARALQAAHERGFVHRDVKPGNILVRSDGLIKITDFGIAKAADAVPVTRSGMVMGTAHYIAPEQASGAEAGPAGDVYSLGIVGYECLAGHRPFRADSAVAVAMMQVRDEPPPLPDTIPLPARELIESVLVKDPTQRYASGGEFAEAVAAVRRGEPMPVPSGLTPHGGSAPVATPSRSRRAAAPPPVPAPDDRYAVPADRYAPDPYRVDARPADPYGPSDDGEVYIGDRPYEPVRRAPAGPTEPLRLQPTSGPGRGLLIVLFVLLTVAAVVVGIFVLRALGEDDPGAGAGMRVGPVPTVVIDTGSGR
>NZ_CP053564.1|WP_172156062.1|1537912_1539835_+|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase
MTTPRLLSERYELGDTLGYGGMSEVHHGLDTRLGRDVAIKVLRADLARDPQFQMRFRREAQNAAALNHPAIVAVYDTGEVQSEFGPLPYIVMEFVDGQTLREIVKTTGPMSQQRVIEVMADVCAALDFSHRHQIIHRDVKPANIMINNAGAVKVMDFGIARALGEGQNVTQTAAVIGTAQYLSPEQARGEAVDARSDVYAAGCVLFELLTGEPPFTGDTPVAVAYQHVREDPRRPSELNPDIPAALDSVVLKALSKNPANRYQSAAEMRSDLVRVRSGQTVMAPAVMSEDERTAMLASQTGPTRRINGGGRHTLPPSAPAYYDDEEPRRGTGRIVGIAAAVAIALALIGFVAYQIFGGPAAPEQFAMPDVVGQEQEAARTALINLSLNPTVQTEESSVDDQGRVVRTDPPATSLVEERRAVTLFVGSGPAVAAVPPLAGLSITDAETALAARGLTLGEQTPEETRDEALIGKIIRSTPAAGADAPGGSAVAVVVGTRPTTVAVPDVTGQGRDQARSALETAGFEVAETEVDGGGEGGDVLGTEPSAGTQAAPGSTVTLQLSRGNQVQVPDLVGLDRSDALRAIQQAGISLSDVNQRERGVSDNSQDGRVIEQSVAAGQSLEEGDELTITIGDAGGGFFGN
>NZ_CP053564.1|WP_172156064.1|1539862_1540498_+|aminodeoxychorismate/anthranilate-synthase-component-II
MRVLVIDNYDSFVYNLVQYLAQLGAETTVRRNDEVDLDELDDVDGVLVSPGPGTPERAGASVEAIRRCADRALPLLGVCLGHQAIGVAWGGVVERAPELLHGKTSLVHHGGDGVLAGLPDPFVATRYHSLSIRPGTVPAELEVTGRTETGVIMAVRHRELPIEGVQFHPESVLTEGGHRLLANWMTAAGHAPSPADVDALTAETAALSARA
>NZ_CP053564.1|WP_172156075.1|1540580_1540850_+|cell-division-protein-CrgA
MPKSKVRKKTVYTPPAGDRRTTTPVKVKGPTNPVYVAVFLGLMLLGLVWLVVNYLAVDYIPWMAALGPANFLIGFSLIVIGLLMTMRWR
>NZ_CP053564.1|WP_172156077.1|1540912_1541359_+|PH-domain-containing-protein
MSDHGSAVRSWSPAPGLVVLGWLAAAAATAWCVLLVTSGADPAGRLLAGCAAVGLAVAALYGTRARPRLRADADGLTVGGLLRARHHPWPLVQGVRVLRTRRFGRESSLLEVDTVTADGGERLLLFGRLDLGADPEDVAPELMDLRPR
>NZ_CP053564.1|WP_172156089.1|1541344_1542205_-|rhomboid-family-intramembrane-serine-protease
MTHPAGPPTGAPVVCVRHPDRPTGLACTRCGRPSCPECLREAAVGYQCVDCVHQGRHDVRRATTVAGAVVGSRPVVVPALVVLNLLVFAVTAAQAGSIAANTRSALFAAWALSPGTVAAGEWWRTVTSGFLHIGPVHLAFNMFALWVIGRDMEGLLGRGRFLAVYLLGMLGGAAAVMLLYGPGEYVAGASGAVFGLMGGLAVALVRLKRPLNQVGGLLAVNLALGFFVPGISWQAHVGGLLAGAAATAVLVYAPPARRAPLQAGGLAAIAVVLLVVIAVGALLAGT

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Crispr_ID: NZ_CP053564_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053564_2

2727641-2727738

Orphan

Consensus_repeat	Method
CGGTGATCACCGGCTCGTGATCGTCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP053564_2

>merge|NZ_CP053564|2|2727641-2727738|CRISPRCasFinder
CGGTGATCACCGGCTCGTGATCGTCGAGACTGTGACCTCAAGGTCGTCGCGGGGGCCGTGAGGGTGCGGTTTCGGTGATCACCGGCCCGTGATCGTCG

>NZ_CP053564|2|1|2727641-2727738|CRISPRCasFinder
CGGTGATCACCGGCTCGTGATCGTCG	AGACTGTGACCTCAAGGTCGTCGCGGGGGCCGTGAGGGTGCGGTTT
CGGTGATCACCGGCCCGTGATCGTCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053564.1\|WP_172158388.1\|2722967_2723480_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028
NZ_CP053564.1\|WP_172158386.1\|2721209_2722499_+\|glutamate-mutase-L	unknown	unknown	gnl\|CDD\|379405
NZ_CP053564.1\|WP_172158401.1\|2731768_2733499_+\|GerMN-domain-containing-protein	unknown	unknown	gnl\|CDD\|237449
NZ_CP053564.1\|WP_172158406.1\|2735414_2738420_+\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NZ_CP053564.1\|WP_172158385.1\|2719462_2721103_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|341284
NZ_CP053564.1\|WP_172158390.1\|2724033_2724393_-\|Tat-pathway-signal-sequence-domain-protein	unknown	unknown	gnl\|CDD\|235777
NZ_CP053564.1\|WP_172168302.1\|2726905_2727112_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053564.1\|WP_172158383.1\|2718939_2719413_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053564.1\|WP_172158389.1\|2723476_2724037_-\|class-F-sortase	unknown	unknown	gnl\|CDD\|320678
NZ_CP053564.1\|WP_172158397.1\|2728626_2729301_+\|dTMP-kinase	unknown	unknown	gnl\|CDD\|236133
NZ_CP053564.1\|WP_172168306.1\|2733723_2734335_+\|ComF-family-protein	unknown	unknown	gnl\|CDD\|223970
NZ_CP053564.1\|WP_172168304.1\|2729308_2729995_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP053564.1\|WP_172158387.1\|2722515_2722971_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP053564.1\|WP_172158414.1\|2740258_2740555_-\|antitoxin	unknown	unknown	gnl\|CDD\|379416
NZ_CP053564.1\|WP_172158408.1\|2738499_2739180_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP053564.1\|WP_172158394.1\|2726363_2726789_+\|ester-cyclase	unknown	unknown	gnl\|CDD\|377824
NZ_CP053564.1\|WP_172158411.1\|2739802_2740180_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|273662
NZ_CP053564.1\|WP_172158391.1\|2724681_2726184_+\|adenosylhomocysteinase	unknown	unknown	gnl\|CDD\|377487
NZ_CP053564.1\|WP_172158402.1\|2734584_2735250_+\|ribosome-associated-translation-inhibitor-RaiA	unknown	unknown	gnl\|CDD\|129824
NZ_CP053564.1\|WP_172158399.1\|2730017_2731772_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715

Protein	Function_ID	Function_description	E-value
NZ_CP053564.1\|WP_172158388.1\|2722967_2723480_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	1.01582e-29
NZ_CP053564.1\|WP_172158386.1\|2721209_2722499_+\|glutamate-mutase-L	gnl\|CDD\|379405	pfam13941, MutL, MutL protein. This small family includes, GlmL/MutL from Clostridium tetanomorphum and Clostridium cochlearium. GlmL is located between the genes for the two subunits, epsilon (GlmE) and sigma (GlmS), of the coenzyme-B12-dependent glutamate mutase (methylaspartate mutase), the first enzyme in a pathway of glutamate fermentation. Members shows significant sequence similarity to the hydantoinase branch of the hydantoinase/oxoprolinase family.	7.92685e-101
NZ_CP053564.1\|WP_172158401.1\|2731768_2733499_+\|GerMN-domain-containing-protein	gnl\|CDD\|237449	PRK13616, PRK13616, MtrAB system accessory protein LpqB.	6.28128e-107
NZ_CP053564.1\|WP_172158406.1\|2735414_2738420_+\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NZ_CP053564.1\|WP_172158385.1\|2719462_2721103_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|341284	cd12119, ttLC_FACS_AlkK_like, Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles. This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family catalyzes the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified from Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes uncharacterized FACS proteins.	0
NZ_CP053564.1\|WP_172158390.1\|2724033_2724393_-\|Tat-pathway-signal-sequence-domain-protein	gnl\|CDD\|235777	PRK06302, PRK06302, acetyl-CoA carboxylase biotin carboxyl carrier protein.	0.00034597
NZ_CP053564.1\|WP_172158389.1\|2723476_2724037_-\|class-F-sortase	gnl\|CDD\|320678	cd05829, Sortase_F, Sortase domain found in the class F family of sortases. Class F sortases are mainly present in Actinobacteria, Chlorobacteria and Firmicutes. Their functions are largely unknown.	2.41132e-57
NZ_CP053564.1\|WP_172158397.1\|2728626_2729301_+\|dTMP-kinase	gnl\|CDD\|236133	PRK07933, PRK07933, dTMP kinase.	3.90805e-92
NZ_CP053564.1\|WP_172168306.1\|2733723_2734335_+\|ComF-family-protein	gnl\|CDD\|223970	COG1040, ComFC, Predicted amidophosphoribosyltransferases [General function prediction only].	7.90926e-29
NZ_CP053564.1\|WP_172168304.1\|2729308_2729995_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	5.91618e-85
NZ_CP053564.1\|WP_172158387.1\|2722515_2722971_-\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	1.81387e-07
NZ_CP053564.1\|WP_172158414.1\|2740258_2740555_-\|antitoxin	gnl\|CDD\|379416	pfam14013, MT0933_antitox, MT0933-like antitoxin protein. This family of proteins contains the MT0933 protein, which has been identified as an antitoxin to /protein MT0934. This family of proteins is found in bacteria. Proteins in this family are typically between 61 and 90 amino acids in length.	1.14376e-09
NZ_CP053564.1\|WP_172158408.1\|2738499_2739180_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	9.71113e-18
NZ_CP053564.1\|WP_172158394.1\|2726363_2726789_+\|ester-cyclase	gnl\|CDD\|377824	pfam07366, SnoaL, SnoaL-like polyketide cyclase. This family includes SnoaL a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486. The proteins in this family adopt a distorted alpha-beta barrel fold. Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalyzing intramolecular aldol condensation.	4.08425e-35
NZ_CP053564.1\|WP_172158411.1\|2739802_2740180_+\|HAD-IA-family-hydrolase	gnl\|CDD\|273662	TIGR01509, HAD-SF-IA-v3, haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. This model represents part of one structural subfamily of the Haloacid Dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. The superfamily is defined by the presence of three short catalytic motifs. The subfamilies are defined based on the location and the observed or predicted fold of a so-called "capping domain", or the absence of such a domain. Subfamily I consists of sequences in which the capping domain is found in between the first and second catalytic motifs. Subfamily II consists of sequences in which the capping domain is found between the second and third motifs. Subfamily III sequences have no capping domain in either of these positions. The Subfamily IA and IB capping domains are predicted by PSI-PRED to consist of an alpha helical bundle. Subfamily I encompasses such a wide region of sequence space (the sequences are highly divergent) that representing it with a single model is impossible, resulting in an overly broad description which allows in many unrelated sequences. Subfamily IA and IB are separated based on an aparrent phylogenetic bifurcation. Subfamily IA is still too broad to model, but cannot be further subdivided into large chunks based on phylogenetic trees. Of the three motifs defining the HAD superfamily, the third has three variant forms: (1) hhhhsDxxx(x)D, (2) hhhhssxxx(x)D and (3) hhhhDDxxx(x)s where _s_ refers to a small amino acid and _h_ to a hydrophobic one. All three of these variants are found in subfamily IA. Individual models were made based on seeds exhibiting only one of the variants each. Variant 3 (this model) is found in the enzymes beta-phosphoglucomutase (TIGR01990) and deoxyglucose-6-phosphatase, while many other enzymes of subfamily IA exhibit this variant as well as variant 1 (TIGR01549). These three variant models were created with the knowledge that there will be overlap among them - this is by design and serves the purpose of eliminating the overlap with models of more distantly related HAD subfamilies caused by an overly broad single model. [Unknown function, Enzymes of unknown specificity].	1.9618e-21
NZ_CP053564.1\|WP_172158391.1\|2724681_2726184_+\|adenosylhomocysteinase	gnl\|CDD\|377487	pfam05221, AdoHcyase, S-adenosyl-L-homocysteine hydrolase.	0
NZ_CP053564.1\|WP_172158402.1\|2734584_2735250_+\|ribosome-associated-translation-inhibitor-RaiA	gnl\|CDD\|129824	TIGR00741, Probable_sigma54_modulation_protein_ORF3_ORF95., ribosomal subunit interface protein. This model includes a small protein encoded by one of two genes, both downstream of the gene rpoN for sigma 54, whose deletion leads to increased expression from sigma 54-dependent promoters. It also includes the N-terminal half of a light-repressed protein LtrA of Synechococcus PCC 7002 and the N-terminal region (after removal of the transit peptide) of a larger plastid-specific ribosomal protein of spinach. The member of this family from E. coli is now recognized as a protein at the interace between ribosomal large and small subunits, with about 1/3 as many copies per cell as the number of ribosomes. [Protein synthesis, Translation factors].	7.8463e-29
NZ_CP053564.1\|WP_172158399.1\|2730017_2731772_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	4.98683e-50

>NZ_CP053564.1|WP_172168302.1|2726905_2727112_+|hypothetical-protein
MRGIDGFVAYYLIDAGPGRVTTVSVFSDRAGAEESTRAGAKFVSDNLAGWAPNPPTVVQGEVALDAFP
>NZ_CP053564.1|WP_172158394.1|2726363_2726789_+|ester-cyclase
MADTAQLAAARRLLDEVWGKGNLDVTHELIAEDFVRHGPDVEGGGVTGREAFKGLVTAYRDGLPDLQVPVIEMFEFGDRVLSTWRVTGTMTGPALGQEPTGRSLDMTGQHLLRFADGRIVEEWCAYDTMGLVQQLGLQPPA
>NZ_CP053564.1|WP_172158391.1|2724681_2726184_+|adenosylhomocysteinase
MSVDTTADPTGKLQTRNGIDFAVADLSLHEFGRKEIRLAEHEMPGLMELRREYAEARPLHGARIVGSLHMTIQTAVLIETLVSLGAEVRWVSCNIFSTQDHAAAAIVVGSGTPEEPKGVPVFAWKGETLEEYWWCTEQLFLFRDDQGEIVGPNMILDDGGDATLLIHKGVEYEKTGVVPTVEDEDLTVSDEYRIILDTLRRSLTADPQRWTKVASDIRGVTEETTTGVHRLYQLAEQGALLFPAINVNDSVTKSKFDNVYGIRHSLVDGLNRATDVLIGGKVALVCGFGDVGKGSAAALAGQGARVIVSEVDPICALQALLQGFQVATLESTIEKADIIVTTTGNKDIITTDAMKRMKHQAIVANVGHFDNEIDVAGLGRIPGIIKINIKPQVDEWVFPDGHSIILLSEGRLMNLGNATGHPSFVMSNSFANQVIAQVELFTKFEEYNKDVYRLPKHLDEKVAKIHVLALGGELTKLSKDQAEYIGVDVEGPFKPEHYRY
>NZ_CP053564.1|WP_172158390.1|2724033_2724393_-|Tat-pathway-signal-sequence-domain-protein
MTPSPRRVLASSVLGIALLTAWPATASAQTPPPPPSPPVTVAPVPATPGPAVAPTAVPAVPAAPAEGGQVAVVPRGGADTGGGALATAGPDPALLGGALLLGLVGAGAAGVARTRRGRG
>NZ_CP053564.1|WP_172158389.1|2723476_2724037_-|class-F-sortase
MSRVAALVLLVLALVAGCAAGPAPASGTPAPAAARPAAGPVALDIPALGVRTPLLSLGLQPDGTVEVPPLDDVGVAGWYRHSPVPGEVGPAVLLGHVDSARDGPGVFAGLTRLRPGDAVTVVRGDGSTEAFRVDRVESFAKDAFPTQQVYGDLDHPGLRLITCGGTFDEERRSYRDNVVVFASGAP
>NZ_CP053564.1|WP_172158388.1|2722967_2723480_-|sigma-70-family-RNA-polymerase-sigma-factor
MNSGDRAAFEAFVLAHGPGLVAFARRLTLDHHRAEDVVQDVLARMAPTWPPDARDPLAYVHTAVLRQFLSWRRRFSSRERPGPDVGADVGAHGGFADDVVERHRVHRALAALPPAQRAVLVLRYHHDRADAEIAALMGCRESTVRSHARRGIAALRAAGLLDPTSEETLR
>NZ_CP053564.1|WP_172158387.1|2722515_2722971_-|hypothetical-protein
MTDHDGTADEDAVRDLLRAAAPERPVSGAALLAGVRVRVERRRRRRRTATVAAAALAAAAVVGGSGLLAARTSAPLLVPAGQPTSTPVPQAPAVPGPPAETAVPVPAPPVTTLAPVPASAVPQATPAKPPPLATTATPSPAAPPPAAVPPP
>NZ_CP053564.1|WP_172158386.1|2721209_2722499_+|glutamate-mutase-L
MTPVHPDTAAVCLDVGSTWTKAVLVRADGGLAGFAEHPTTTGDVLAGMDATVRAVSAAGGSAAEPELLACSSAGGGLRLAVVGSDTLSSTEAGHRVACSAGAHVVHVHAGPLEPADVRALRNSRPGVVLLIGGSDGDDPALLLHNASRLARARIRPPILLAGNTEGRAEALATLLATGRTVVTSENVLPRLGEVVPEPARAALAGLYQRHAIGGRGATVAPRFRRLVRVVTPDAVARGAAELARIRGGKVLLVDVGCATTDVHSVDATGAVRTVEGDLGVRAAAASVLVEGQAEGVVDPVEADLLAPTVARMASEVAFVPSDAGSAAEDRRIAALASVVAVRRHLRARADAADGLGLVVLTGGVFRQRASGNGLGSVIATLCADPVLAAALGDVEVVVDADFTVAPAGLLATHGRADAAEALLRDHLLG
>NZ_CP053564.1|WP_172158385.1|2719462_2721103_-|long-chain-fatty-acid--CoA-ligase
MLGLMQDRPLTLPHVFHRAEQYFAHKTVVTAEADGETSMTIGEWAGRVRRLATVLDTLGVSADGRVGTFCWNTGRHLELYLAAPCTGRVLHTLNIRLFPEQLVYIVDHAEDEVVFVDRSLIPVIAPLAAKMGTVRQFVVIDDGADAEVPEGWLDYEELLAAAEPFTGTFVVEDENTAAAMCYTSGTTGNPKGVVYSHRSAVLHSLITLTADAFALSERDVVLPVVPMFHANSWGLPYGCLLAGSDLVMPGPNMTPQAIASLLARHRVTVTGGVPTIWMGMLPMVGDHDLSHLRMIVCGGSAVPRSLSESYRTTVGIPLTQAWGMTETSPIATMSTPRSHHDALTEDERADIRARQGQPVPFVDMRLVDPDSGEVQPWDDTATGEIQAAGPWIAKEYYRGEGGGAQYTEDGWLRTGDVGTGDRYGFVRLVDRTKDLIKSGGEWIGSVELENEIMAHPKVAEAAVIAIPSEKWVERPLACVVVKPGETLTGEEVIEFLTPRVAKWWLPDAVEFIDEVPKTSVGKFSKKTLREKFGGYQVAGPTSHEPA
>NZ_CP053564.1|WP_172158383.1|2718939_2719413_-|hypothetical-protein
MEDEVMARVTAAVQRGQGGERTAARRELESLWDGDGRADAFHRCVIAHFLADLQDDTGDELRWDERALAAVDGVTDERAQEYGTALRVRGFLPSLLGSLADDHRRLGDAEQARGFLEQARAASDALGDDGYGDLVRGILDRVGRALDEGSTAPLPDA
>NZ_CP053564.1|WP_172158397.1|2728626_2729301_+|dTMP-kinase
MGALVVVEGLDGAGKRTLTDALSTALAARGARVARTAFPRYDDDVHAELVRDALYGRLGDLSGSVHGMTLLFALDRRAAGPLLRADLEAHDVVLVDRYAASAAAYGAARLHQDAAGEFVEWVRELEFGRFGIPVPDHHLLLAVPHAVAADRAAHRERTEAGRERDTYESDGGLQERTGAVYAGLAAASWVAPWTVLDGVAGVDADALAARLLGEEPVSARPAHG
>NZ_CP053564.1|WP_172168304.1|2729308_2729995_+|response-regulator-transcription-factor
MTRMKSRVLVVDDDPALAEMLTIVLRGEGFDTAVVADGTRALPAVRELRPDVVLLDLMLPGMNGIDVCRAIRSESGVPIVMLTAKSDTVDIVLGLESGADDYVVKPFKPKELVARIRARVRRTENEPAEQLAIGDVTIDVPAHQVVRHGEQIALTPLEFDLLVALARKPRQVFTREVLLEQVWGYRHAADTRLVNVHVQRLRSKVERDPEHPEVVLTVRGVGYKAGPP
>NZ_CP053564.1|WP_172158399.1|2730017_2731772_+|HAMP-domain-containing-histidine-kinase
MSPGRLRRGLAQARQFGGEVAEASGAVWRRSLQLRVVISTLALSTAVVLVLGLVLQTQIAQRLVQGKEADTLLRFEAGVSLLERDLSGVDPDREGAEGELNNALAQLTSADSDGEATAAGEFRAVLTTGRRDGGEEISAGPVDDVPAELRRDVGEDSTLARQYATITQNGVAVPTLVVGQPVRTAGPRGLEFYMLFPLDSEQRTLGLVQSTLIVAGLLLLLLLAGIVSIVTRLVVRPVREAAEIAERFADGHLDERMRVQGDDEVARLGESYNEMAQSIQSQIQQLEEFGALQRRFTSDVSHELRTPLTTVRMAADVLYASREELLPALRRSSELLVTELDRFEALLADLLEISRLDAGVADLVAENVDVRSVVLRAVEAVRGIADETGTELDLDLPEGILAEIDNRRVERIVRNLVANAVDHGEGRPVRVQLAADDRAVAVLVRDQGVGLRPGEAGLVFNRFWRAEESRARRSGGSGLGLSISVEDARLHGGWLQAWGEVGRGAAFRLTLPRVAGGVLVDSPLPLGPDESTPPAPMTSVPTPARGMPLVEPAVQWLPGDDVDEPDDDRGDGARPAADLAGEQR
>NZ_CP053564.1|WP_172158401.1|2731768_2733499_+|GerMN-domain-containing-protein
MRRATVALAVLLALSGVAGCASVPGSSPVQILRDVTDGETAVLPPGPVDGTDAGGLVRGFVEASGSSADDHGAARLFLAPEAQDWDAGAGFTVLDSQFDTVPSPGAPDPSSDTTRIRIRGSSVGRVTASGSFEPEQAPVQIDVTVVRRNGQWRISELPDGVVLPLDEFRTSYRDVRTWFVDPARRVVVPDLRYLPAFPSRAQASRAMELLLAGPSGALLGAVDSQLDAGARLRSNVALTETGALIVDLTRVGDLDEPGRRLLAAQVVLSLGEVNVARVRLLVDGIPLITGRPELTREDVADLNGDVQPAADVPALVVAGGRLRGLGAGSAGSEQPGPLGNGAYDVESAASSVDGQRVAAVARSSGRRLLLVGGGADGGVAEIGLSAVDMTRPSWTPTGSEVWTVMDSTTVARVLVDGAGTPRTGQVNADELAAFGPIQDLRLSRDGMRVVAVVAGGLYTAAVTRSLDGEAAVRNIRRLRPADLGEVVSADWRSAEAVVAITRRADRLVAQVSVDGLSVQGLLVNNLTPPLGAVAAAPSRAFLVTDQSGVWSFAGGDQDAWRQVLGGAPDAVPFYPG
>NZ_CP053564.1|WP_172168306.1|2733723_2734335_+|ComF-family-protein
MTDLVLPAGCAACGAPEAPWCPACASLLTGPHRVGLPGLPPTLAVGRYAGPLRTALLRYKERGRRDLAVPLAALLAAGLSGAPVDLVPAPSRAAAARARGGDHVVRLARAAAAGRAGVRVVPVLGLARGAADSVGLDAAQRTANLRGRVHVRAPLRPRPGADVLLVDDVVTSGATLRAAVGAFAAAGVRVDGALVLCDATGAC
>NZ_CP053564.1|WP_172158402.1|2734584_2735250_+|ribosome-associated-translation-inhibitor-RaiA
MEIVVTGRNVEVPEHFRVHVAEKVARLERYDHKIVGLEVELFHEPNRRQLKTCQRVELTGRGCGPVARAEACAQDFYAALDAAVAKLEARLRRSHDRRRVTGRRTQVLVGRAASNGRGTALLEEAPPLDTETDVDIPFPRDAVDDALPDHLPPEATDDDPAPGRVVRRKVHTADPMSVDEALSHMELVGHDFYLFSDSESGEPSVVYRRKGYDYGVIRLGR
>NZ_CP053564.1|WP_172158406.1|2735414_2738420_+|preprotein-translocase-subunit-SecA
MPLLDRLLRAGETKLVKRLGRIAAHIDTLEADVEGLTDAELRAKTDEFRSRYADGETLDEMLPEAFSVVREAARRTIGQRPFTVQLMGGAALHLGNIAEMKTGEGKTLTSTLPAYLNAISGEGVHLVTVNDYLAKRDAENMGRIHRFLGLSVGVILSEMPPLIRRGQYQADITYGTNNEFGFDYLRDNMAWNKADMVQRGHNFAVVDEADSILIDEARTPLIISGPAEQSARWYQEFARMAPMLKRDVHYEVDERKRTVGVTEEGVALVEDQLGIDNLYEAANTPLVGYLNNAIKVKELFKKDKDYIVRDGQVLIVDEFTGRVLAGRRYNEGMHQAIEAKEGVEVKAENQTLATITLQNYFRLYERLSGMTGTAQTEAAELNQIYKLGVVPIPTNKDMIRKDQPDLIYKTEEAKFEAVADDIAEKHAAGQPVLVGTTSVEKSEYLSKLLVKRQVPHEVLNAKQHEREAAIVAQAGHAGAVTVATNMAGRGTDIVLGGNPEFLADLELRRRGLDPVEKREEYEAAWDETVAAMKAQVAAEAEEVKAAGGLYVLGTERHESRRIDNQLRGRSGRQGDAGESRFYLSLGDDLMRRFNGHMVESIMNRFNLPDDVPIEAGMVTKAIRSAQTQVEQQNFEIRKNVLKYDEVLNQQRTVIYSERRRVLAGENIQEQIEHMLTDVVTAYVEGETGQGYSEDWDLDKLWTALGTIYPIGIRWQDLADSDDEGDLDDPGDLTKDRLLTAVLEDARGAYARREAEIDAIIGAQGGMRELERQVLLQVIDRKWREHLYEMDYLKEGIGLRAMAQRDPVIEYQREGYDMFSAMLEGIKEETVGHLFNVKVQAPAPPAAAPVDGAAPAAAAAPAAVPAAAVPAAAAPATAAPAPAAAPPAQAAPAAPAAPAAAPAASSARPSGRRRRPEPAVSAPSDDAATTSVLPTAYQGARPADLRYSGPTEDGGTATSGGGGRTARGAARSESEPSRNRPCPCGSGRKYKQCHGSATAARP
>NZ_CP053564.1|WP_172158408.1|2738499_2739180_+|MarR-family-transcriptional-regulator
MHPVPDALAAGLLLPRAGQAVDRLLRRAVAAHGLTPTSLGVLGVLARGRPASHRDLAAALGIAPATLTPAVDALERGGLVRRVRDTVDRRVVQVRATDAGLTRYAGAVDAAARELGERVPTPPGAVADAVRDYLLAVVAAAEGAAVPGQALPGAATRVDGAGAEGAAVVAARGASADPDDGPAPAPVAQVEAGGQRADPSVELDGHRDLGGVGARVAEPDPAEPGR
>NZ_CP053564.1|WP_172158411.1|2739802_2740180_+|HAD-IA-family-hydrolase
MLRALVMDYGGVLTDGPEVLDLVRRARAAGHPTALVSDAHAVSDDVAALFDVLVLGPVLGVRKPDPEVFRRTAQRLGVDVTECVVVDDLAANVRGARAAGAVVVHHVDAGTTVDEVEVLLGLPGA
>NZ_CP053564.1|WP_172158414.1|2740258_2740555_-|antitoxin
MSFLDKAKDLLNQHDDKVDQALDKGGEAAKARFAGHEGHIDGIVDQAQQRTGAGDTTQQAPPAPAQGVPADEQQFEAPAPGQNQPGEPEPGAVPPHQQ

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Crispr_ID: NZ_CP053564_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053564_3

3361205-3361275

Orphan

Consensus_repeat	Method
CCACTCACGGGTGCTCGTGAGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP053564_3

>merge|NZ_CP053564|3|3361205-3361275|CRISPRCasFinder
CCACTCACGGGTGCTCGTGAGCGGCGATCGTGGCTCTGGCCGTGGTTGCCACTCACGGGTGCTCGTGGGCG

>NZ_CP053564|3|2|3361205-3361275|CRISPRCasFinder
CCACTCACGGGTGCTCGTGAGCG	GCGATCGTGGCTCTGGCCGTGGTTG
CCACTCACGGGTGCTCGTGGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053564.1\|WP_172159623.1\|3368294_3369875_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|312032
NZ_CP053564.1\|WP_172159612.1\|3359283_3360036_+\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	unknown	unknown	gnl\|CDD\|236959
NZ_CP053564.1\|WP_172159627.1\|3371168_3371705_+\|rRNA-maturation-RNase-YbeY	unknown	unknown	gnl\|CDD\|234575
NZ_CP053564.1\|WP_172159616.1\|3361290_3361824_+\|isochorismatase-family-protein	unknown	unknown	gnl\|CDD\|238494
NZ_CP053564.1\|WP_172159608.1\|3356182_3356428_-\|ribbon-helix-helix-protein,-CopG-family	unknown	unknown	unknown
NZ_CP053564.1\|WP_172159631.1\|3373067_3374297_+\|L-2-hydroxyglutarate-oxidase	unknown	unknown	gnl\|CDD\|183292
NZ_CP053564.1\|WP_172168472.1\|3353602_3354511_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP053564.1\|WP_172159602.1\|3352775_3353606_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224196
NZ_CP053564.1\|WP_172159614.1\|3360295_3361165_+\|prolyl-oligopeptidase-family-serine-peptidase	unknown	unknown	gnl\|CDD\|224423
NZ_CP053564.1\|WP_172168474.1\|3356432_3356999_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|214979
NZ_CP053564.1\|WP_172159606.1\|3355745_3356186_-\|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl\|CDD\|224761
NZ_CP053564.1\|WP_172159619.1\|3363107_3366962_-\|amino-acid-adenylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|274093
NZ_CP053564.1\|WP_172168476.1\|3358126_3359278_+\|molecular-chaperone-DnaJ	unknown	unknown	gnl\|CDD\|237654
NZ_CP053564.1\|WP_172159618.1\|3361816_3363106_-\|M1-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341066
NZ_CP053564.1\|WP_172159604.1\|3354581_3355697_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319985
NZ_CP053564.1\|WP_172159629.1\|3371724_3373071_+\|HlyC/CorC-family-transporter	unknown	unknown	gnl\|CDD\|224173
NZ_CP053564.1\|WP_172159633.1\|3374370_3375294_+\|GTPase-Era	unknown	unknown	gnl\|CDD\|234624
NZ_CP053564.1\|WP_172159621.1\|3367193_3368210_+\|PhoH-family-protein	unknown	unknown	gnl\|CDD\|224616
NZ_CP053564.1\|WP_172159625.1\|3369903_3371127_-\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|273751
NZ_CP053564.1\|WP_172159610.1\|3357055_3358075_+\|heat-inducible-transcriptional-repressor-HrcA	unknown	unknown	gnl\|CDD\|234621

Protein	Function_ID	Function_description	E-value
NZ_CP053564.1\|WP_172159623.1\|3368294_3369875_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|312032	pfam08386, Abhydrolase_4, TAP-like protein. This is a family of putative bacterial peptidases and hydrolases that bear similarity to a tripeptidyl aminopeptidase isolated from Streptomyces lividans. A member of this family is thought to be involved in the C-terminal processing of propionicin F, a bacteriocidin characterized from Propionibacterium freudenreichii.	1.63752e-19
NZ_CP053564.1\|WP_172159612.1\|3359283_3360036_+\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	gnl\|CDD\|236959	PRK11713, PRK11713, 16S ribosomal RNA methyltransferase RsmE; Provisional.	1.38033e-68
NZ_CP053564.1\|WP_172159627.1\|3371168_3371705_+\|rRNA-maturation-RNase-YbeY	gnl\|CDD\|234575	PRK00016, PRK00016, metal-binding heat shock protein; Provisional.	1.06324e-63
NZ_CP053564.1\|WP_172159616.1\|3361290_3361824_+\|isochorismatase-family-protein	gnl\|CDD\|238494	cd01012, YcaC_related, YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.	4.39125e-53
NZ_CP053564.1\|WP_172159631.1\|3373067_3374297_+\|L-2-hydroxyglutarate-oxidase	gnl\|CDD\|183292	PRK11728, PRK11728, L-2-hydroxyglutarate oxidase.	0
NZ_CP053564.1\|WP_172168472.1\|3353602_3354511_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	3.57062e-86
NZ_CP053564.1\|WP_172159602.1\|3352775_3353606_-\|ABC-transporter-permease	gnl\|CDD\|224196	COG1277, NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only].	6.65473e-07
NZ_CP053564.1\|WP_172159618.1\|3361816_3363106_-\|M1-family-metallopeptidase	gnl\|CDD\|341066	cd09603, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains mostly bacterial and some archaeal M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	7.84843e-160
NZ_CP053564.1\|WP_172168474.1\|3356432_3356999_-\|hypothetical-protein	gnl\|CDD\|214979	smart01022, ASCH, The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain. It is thought to function as an RNA-binding domain during coactivation, RNA-processing and possibly during prokaryotic translation regulation.	0.00020943
NZ_CP053564.1\|WP_172159606.1\|3355745_3356186_-\|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl\|CDD\|224761	COG1848, COG1848, Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only].	1.77268e-13
NZ_CP053564.1\|WP_172159619.1\|3363107_3366962_-\|amino-acid-adenylation-domain-containing-protein	gnl\|CDD\|274093	TIGR02353, NON-RIBOSOMAL_PEPTIDE_SYNTHETASE, non-ribosomal peptide synthetase terminal domain of unknown function. This domain is found exclusively in non-ribosomal peptide synthetases and always as the final domain in the polypeptide. This domain is roughly 700 amino acids in size and is found in polypeptides roughly twice that size.	0
NZ_CP053564.1\|WP_172168476.1\|3358126_3359278_+\|molecular-chaperone-DnaJ	gnl\|CDD\|237654	PRK14278, PRK14278, chaperone protein DnaJ; Provisional.	0
NZ_CP053564.1\|WP_172159614.1\|3360295_3361165_+\|prolyl-oligopeptidase-family-serine-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	2.81816e-16
NZ_CP053564.1\|WP_172159604.1\|3354581_3355697_-\|hypothetical-protein	gnl\|CDD\|319985	cd16327, RseB, RseB, a sensor in periplasmic stress. This family contains the periplasmic protein RseB (also known as MucB or Mucb/RseB) which exerts a crucial role in modulating the stability of RseA, the transmembrane anti-sigma-factor that is degraded during sigma-E-dependent transcription caused by bacterial envelope stress. RseB binds to RseA and inhibits its sequential cleavage, thereby functioning as a negative modulator of this response. The protein is composed of two domains, the larger N-terminal domain resembling an unclosed beta-barrel that is remarkably similar structurally to LolA and LolB, proteins capable of binding the lipid anchor of lipoproteins, suggesting that RseA acts as a sensor of periplasmic stress with a dual functionality, detecting mislocalized lipoproteins as well as propagating the signal to induce the sigma-E-response.	1.84437e-05
NZ_CP053564.1\|WP_172159629.1\|3371724_3373071_+\|HlyC/CorC-family-transporter	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	7.2969e-109
NZ_CP053564.1\|WP_172159633.1\|3374370_3375294_+\|GTPase-Era	gnl\|CDD\|234624	PRK00089, era, GTPase Era; Reviewed.	1.39055e-164
NZ_CP053564.1\|WP_172159621.1\|3367193_3368210_+\|PhoH-family-protein	gnl\|CDD\|224616	COG1702, PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms].	6.79077e-138
NZ_CP053564.1\|WP_172159625.1\|3369903_3371127_-\|FAD-binding-protein	gnl\|CDD\|273751	TIGR01678, D-arabinono-14-lactone_oxidase, sugar 1,4-lactone oxidases. This model represents a family of at least two different sugar 1,4 lactone oxidases, both involved in synthesizing ascorbic acid or a derivative. These include L-gulonolactone oxidase (EC 1.1.3.8) from rat and D-arabinono-1,4-lactone oxidase (EC 1.1.3.37) from Saccharomyces cerevisiae. Members are proposed to have the cofactor FAD covalently bound at a site specified by Prosite motif PS00862; OX2_COVAL_FAD; 1.	4.85537e-37
NZ_CP053564.1\|WP_172159610.1\|3357055_3358075_+\|heat-inducible-transcriptional-repressor-HrcA	gnl\|CDD\|234621	PRK00082, hrcA, heat-inducible transcription repressor; Provisional.	1.81835e-154

>NZ_CP053564.1|WP_172159614.1|3360295_3361165_+|prolyl-oligopeptidase-family-serine-peptidase
MIGRVSRRSVLSRLALALPAGLLAACSTGPRPAEGTAEPVRLDYGPDASQFGELTLPAGDGPVPVVVVVHGGFWRSSYGLELGRPLAVDLANSGVAAWNVEYRRVGNGGGWTATFDDVAAAVDRLADAAASEMGARLDLDRVVAVGHSAGGHLVAWLAARPGLPAGAPGAGPRVRLRGAVSQAGVLDLVDAAERAVGASAVPDLMGGSPAELPDRYAVGSPVARVPIGVPVVCVHGTADANVPIRQSERFTAASGDELVTLPGVDHFAVIDPSTDAWRACRDAAVRLLG
>NZ_CP053564.1|WP_172159612.1|3359283_3360036_+|16S-rRNA-(uracil(1498)-N(3))-methyltransferase
MGTAPLFLVDALPAGPDAVLDGAEGRHAATVRRIRAGEVVQLGDGVGGTALAVVGSVGRDRVDLRITDRAAVAPPAPRVLLAQALVKGDRGELAVELATEAGVDGVLPWRAARCVARWEDGPRGDKALARWRSTAREAGKQARRPWLPVVEEPVTTAALARRVGSVAGALVLHESATAPLASVALPADGDLLLVVGPEGGVTDEELDVLVAAGAQPVRLGAEVLRASTAAAVALGALGVLTGRWNPLHTG
>NZ_CP053564.1|WP_172168476.1|3358126_3359278_+|molecular-chaperone-DnaJ
MARDYYGILGVSSDAGADEIKRAYRKLARELHPDVNPDPGAQERFAEVGAAYEVLSDPEKRRIVDLGGDPLGNGGGGGGGAGDFGAFGFGDIMDAFFGGQGGGRGRGPRSRVQPGADALIRMQLTLEECAVGVTRDLAVDTAVLCTECTGSGCAPGSAPTMCDICAGRGEVQSVQRSFLGQVVTSRVCPNCRGFGEVIPDPCHQCGGDGRVRSRRTVGVRIPAGVADGMRVRLAGQGEVGSGGGPAGDLYVEVEEEPHELFTRDGADLHCTVKLPMTAAALGTNLPLPTLDGTHEITIEPGTQTGAVRTLRGQGMPRLRSTGRVDGHGDLMVHVEVVTPTKLDREQTELLRRLAALREEEQPGVGSGRNGHGLFGRLRDSFGR
>NZ_CP053564.1|WP_172159610.1|3357055_3358075_+|heat-inducible-transcriptional-repressor-HrcA
MNADERRFAVLRAIVADYVSTQEPVGSKMIVERHNLGVSSATVRNDMAVLEEDGLIAQPHTSAGRVPTDKGYRMFVDRLTQVKPLSAAERRAVTAFLDGAVDLDDVMRRSVRLLAQLTRQVAVVQYPTLTRSTVRHCEVVALTPARLMLVLITDSGRVDQRVVDLGQVLTDDDVAQIRTLLGASLTGRPLAAASVAVADLPGTAPAELRDVVTTVATVLIETLVEHPEERLVLGGTGNLTRNVADFPGSLRTVLEALEEQVVVLKLLAAAQDPGTVTVRIGEENEAEEMRDTSVLSIGYGTGTVLGGMGVVGPTRMDYPGSIAAVHAVARYVGEILAGR
>NZ_CP053564.1|WP_172168474.1|3356432_3356999_-|hypothetical-protein
MLIRRPVLDAIAAGSVDMAFRRWSHARVRAGTRLRTAVGLLEVVAVDVVEESDLTAEDARRSGHDSLDALRAANARRDGALFRVTLRPAGPDPRIALRESAVLSDDDRTALDARLARMDRTAPWTGAVLRLIADHPGVRAPDLAARLGRETAPFKRDVRKLKELGLTESLEVGYRLSPRGTAYLHMLM
>NZ_CP053564.1|WP_172159608.1|3356182_3356428_-|ribbon-helix-helix-protein,-CopG-family
MLDHRLQILLDEERYQRISSLAKARGVSVAAVVRDAIDRGLPSVPARRTAAMRRVREAVPMDVGPPEDLRAELDELRGRHA
>NZ_CP053564.1|WP_172159606.1|3355745_3356186_-|type-II-toxin-antitoxin-system-VapC-family-toxin
MIVLDTTVLVYSVGTEHRFREPCARLLDAVASGMVVATTTPEVLQEFAHVRARRRDRDDAADLAEAFSDLLAPLITVDEDAFRAGLRLFRRHPRLGSFDAALAASAVAAGATTVVSADAAFAGLADVRHVVPDEAGVSGLVPTGAT
>NZ_CP053564.1|WP_172159604.1|3354581_3355697_-|hypothetical-protein
MAAPRFSRRWLLVGAGALALVGVDALPRPAGPVSDLPADALRERVLAATGPYVGVAESTARLGLPPLPQLESAVALLTGTTRIRAFVASPERFRVDELTPVGERGTYRLDGREYGWDSDADQLTVITGAAPLRLPRAADLLPPELARRLLRLAPGDPVQPIAARRVAGRTAAGLRLVPTDPATTIGRIDVWADDATGLPLRVEVAPRSAPDEPLLATAFTEVDDRTPDDADLLPEVPPGAGFVRADAGQIAGALRQLDAPDPPAALAGRALVPLTATPGSELPGVGLYGTGPAGFALFPVSREIADRAVDGAALAGGAGVAAGRGRAVVLATPLLTLAVLARGRRGTLLVGTVAADQLEQALLELPDRRRT
>NZ_CP053564.1|WP_172168472.1|3353602_3354511_-|ABC-transporter-ATP-binding-protein
MRTTGLTKRYGRVTAVDGVDLHVPTGVRFGLLGPNGSGKTTLVRMLLGLVHPTAGSVELLGSAMPRHAATVLPRVGALVENPASWAHLSGRANLRLLDAAGPGGRRRDRRARVDDALERVGLGGVDRRPVRAYSLGMRQRLGIAAALLRAPALLLLDEPTNGLDPRGIGEMRTLLTALNEGGTTVVLSSHLLSEVEALCTRVGVMDAGRLVLAEDLDALRTPTGLVTVRTPDPARAAGVLGDAVTARSGDVLTVRDADPAAVNARLVAAGVAVAGLSEQRRSLEQVVLELTGSGSDRIGSHR
>NZ_CP053564.1|WP_172159602.1|3352775_3353606_-|ABC-transporter-permease
MIGVELRLMLRRRRVWLCWGLLCALPALIAALLAGTGIAPAPGQGGAFLSAVVSNGQLFPAAALAIVLPVFLPITVAVVSGDAVAGEAGAGMLRYLLVRPVGRLRLLLAKLVSTAAFVLLAVLFVTVTAYVVGVAAFGFGPDAAAGGGGAVTSLSGTVLTPAQLAERTLFTVGYLALCMLAIGAIGLFFSTLTDSPLAAALGVLAVVVTSAALLPLEAADAIERYLPTTHWLAWIDLYRDPIAWSAVREGAGVQLAYVAVAFGAAWANFATKDITS
>NZ_CP053564.1|WP_172159616.1|3361290_3361824_+|isochorismatase-family-protein
MLLTAESSTLLLVDLQERLMPVIHDGPSVVANARRLAEGAGLLDVPVCATEQNPAGLGPTVPEVAAFPQLVMAKTSFGAVAEAGFATLLPPGTEEVVVAGCEAHVCVLQTVLGLLAKRHRVLLVADAVGSRDPRNRDLAIDRMQRHGAEVVSTEMVLFEWLRDSHHPRFREVHKLIR
>NZ_CP053564.1|WP_172159618.1|3361816_3363106_-|M1-family-metallopeptidase
MTGPEVGADPYLPGHGTTDLRVRHYDLELDYRVGANRLAARAVLTAECDAPLPRFALDLAGLTVRRVAVDGRVARFTHRGGKLRVTPARPVSGQFVVEVRYGGNPRPVRGRWGDIGWDELTDGALVASQPVGAPSWFPCNDHVGDKAAYRMTVTAEAPYTVRATGVLTGRRRSAGTRTWVFERPEPTATYLAGVQIGRYEELPLGPGQTAFVPPRLRRAAARDLGRHAAMMRTLTGWFGPYPFAEHQVVVADDDLDVPIEAQGMSVFGANHVDGRRTHERLVLHELAHQWFGNSLTIAGWRHIWLNEGFATYAEWLWSEASGGRSAAAHAAEWHAAIAPRRPDLVLADPGVGGLFDERVYKRGALTLHALRGRVGDPVFFALLRDWAVRHRHGSVTTEQFVALAGEHAGTDPSGLFDAWLHRKPLPPLT
>NZ_CP053564.1|WP_172159619.1|3363107_3366962_-|amino-acid-adenylation-domain-containing-protein
MPPPPAPQPPAPEGTVTLALAPALVPARFTAGPTPPGRTLLDVLAATAELVPHEPAVDAAGTLLTYRGLAQEVDALRAELVAAGIGVGDRVGVRRSSGTAGLYVAVLGVLAAGAAYVPVDADDPEERAALVFGEAAVCAVLTDAGLDVVGAPNGRPGRPGPDDDAWIIFTSGSTGTPKGVAVTHRSAAAFVDAEARLFLGGEEHGDEPIGPGDRVLAGLSVAFDASCEEMWLAWRHGACLVPAPRALVRTGVDLGPWLRAQRITVVSTVPTLAALWPADALEEVRLLIFGGEACPPELAARVAVEGREVWNTYGPTEATVVACAAPLHADAPVRIGLPLDGWELAVVDAAGEPVAMGGTGELVIGGVGLARYLDAAKDAEKFAPAPALGWDRAYRSGDVVRAEPEGLVFLGRADEQVKLGGRRIELGEVDAALAALPGVRGAAAAVRRTTAGNQVLVGYVAAADLDHDAAAAALRERLPAALVPLLAVVDELPTRTSGKVDRDALPWPLATASAAGLTPTEAWLAEGFAEILGAGVSGPSADFFSLGGGSLTAAQLVARIRTRHPQVAVDDLYRHPRLGALAAHVDALRGGEATVREVAPVPARTGFLQALLSLPVLLLVGLRWTAVAGAVSTVAALVGTGPGIVVPWWALALAWVALFSPAGRVAVAAGGARLLLRGVGPGTYPRAGSVHLRIWAAERLAERSGVTGVAGASWTLRYARLLGARVGADVHLHAPPPVTGLLKVGRGASVEPEVDLSGHWVDGDLVHVGRIRIGAGARVGARSTLLPGTRIGKGAEFVAGSTVEGAVPAGQRVAGSPAARTGRSRLEWPADPAPRSRAWVAVYALTSAALGLLPAVAALPGLALVVGTGSLLAVPVATLAHLVTYALLVLVAVRLLGVGMAAGYHPVHGRTGWQVWTTERLMGMARTGLFPLYASSLTPHWLRALGATVGRDVEISTVVALPRMTTVADGAFLADDTLVGTYELRGGWLHVAPSRIGKQAFLGNSGMTAPGRSVPNRGLVGVLSATPRKAKKGSSYLGLPPMPLQRSAGDADTARTFHPPRRLRLARALVELCRVVPVVLSATLAVLVLTAVLAVWQAAGVLVAAALAGPFVLVAGVLAASTAVLAKWVLVGRFRAVEHPLWSAFVWRDELADTFVEVLAVPWLVGPATGTPVLSAWLRAMGASIGRGAWVETYWLPESDLVAIGDGATVNRGCVVQTHLFHDRIMSMSPVRLADGATLGPHGIVLPGAGIGAGTTVGPGSLVTRGDEVPAGTRWRGNPITSWS
>NZ_CP053564.1|WP_172159621.1|3367193_3368210_+|PhoH-family-protein
MAVPDAALLALLGRRDETLRMAEEMLDADVHVRGNELTLSGAPADVAFAERVFTELITLAERGQQVAPDAVRRTVEMLGAGEETLGESPAEVLSLDILSRRGKTIRPKTLNQKRYVDAIDAHTIVFGIGPAGTGKTYLAMAKAVQALQAKMVNRIILTRPAVEAGERLGYLPGTLFEKIDPYLRPLYDALHDMIDPESIPKLMAAGTIEVAPLAYMRGRTLNDAFIILDEAQNTTPEQMKMFLTRLGFGSKIVVTGDVTQVDLPGGGTRSGLHVVRDILDGVDDVHFSALSSQDVVRHRLVADIVDAYSRWDAETARPDLRSAAPRNGPPQDRRARRR
>NZ_CP053564.1|WP_172159623.1|3368294_3369875_+|alpha/beta-fold-hydrolase
MRSSRRVASAVVLAAALLLPVAGPAAADPVVSPLAPALNPYFAQELTWGACTDLARTAADREAYANPQYDCAFLEVPLDYGDPAASTARIAMLRQRALDPAARIGSLFVDPGGPGGSGVSFLPALAGLLGDGEVARRFDLIGFDPRGVGVSEPSIDCSTTEEVDAERADLDLDTSPEGVAQTEAEFREFADRCAERVGLDVLENVGTRDVARDLQIAHEVVGDPQLTYLGYSYGTSIGTEFAEQFPTEVRALVLDGAVDPSLDPVASRTTQARGFQRAFDGFAAYCAAQPECPLGTDAAGASARVQELLTPLVDAPVPTSDAGRELGYADAVTGMVQALYADSLWPPLLDGLRQVARGDGTNLLILSDIYYDRAPDGSYGNLLEAFPVISCMDGDRLTDRAVAREVNEANLALAPFLDAGYGASDVLELCSFWPVPPTSDPGPVDAPGLPPVLVASSTGDPATPYEDGVSLARQLSARLLSVDNDGHTVVLQGVNACADEVTTRYLVDLVLPPADMTCARPPAPAS
>NZ_CP053564.1|WP_172159625.1|3369903_3371127_-|FAD-binding-protein
MTRARNWAGNVVFSAREVHHPRSVPELQELVAGSDRVRALGTGHSFSPIADTPGDLVVLDSLPAETDLDGDLVTVPGGMPYAELARRLHAAGRALPNLGSLPHISVAGACATGTHGSGDGNGVLATAVVSADVVRADGSLDTVSGPSSVVALGALGIVTSLTLRTVPAFDVAQWVVLDVPFHGFDHLGELLADAYSVSAFTYWERPVFDQVWLKRRVGQGPPEDHWMGGRPADGARHMTRGEPTGNCTDQGGRPGPWHERLPHFRAGFRPSSGEELQSEYLLPRAAAPAALRALEAVAGVIAPVLLVSEVRSVAADDLWLSAAQGRDSVAVHFTWVPDAAAVAPAVAAVEAALDPFDARPHWGKVFTTPPQRVRELWKHLPEFADLARGTDPTGKLRNAMLDRYLPA
>NZ_CP053564.1|WP_172159627.1|3371168_3371705_+|rRNA-maturation-RNase-YbeY
MSIEVSNESGVAMDESLIVSVARFALDAMRVSPAVELAITAVTEDAMSELHERWMEEPGPTDVMSFPMDELLDESRRPDAPDIGPALLGDIVLCPEFAKGNARKAGHPLADELHLLTVHGVLHLLGYDHGEPEEEREMFSLQARLLATWRSSREEAAARAAQRRTDSAVLGAAGLEDG
>NZ_CP053564.1|WP_172159629.1|3371724_3373071_+|HlyC/CorC-family-transporter
MNWSLIVAAVVLVPLAGLFAAADAALLSVSRARVDSLVRMGRPGARALAAVVDDRPRHVNLLLLLRLAAETAATVLLTVALVESSLFEDTAPVWPAALLAGGIMLVVSYVLIGVGPRTLGRQHPYRLAMLVAAPVRALARLLGPLTSLLILVGNAITPGQGFRQGPFSSEVELRELVDMASTTGVVDEDERQMIHSVFELGDTLVREVMVPRPDVVWTEYDTPVEKVLRLALKSGYSRIPVLGENIDDIVGVAYLKDLVAASHTGETTLSSVMRPPAFVPDSKRVDELLKEMQAQRKHMAIVVDEYGGTAGVVTIEDILEEIVGEIADEYDAEEVPDVQPLENGRLRLAARLPVDDLADLFPGIDADDNDLTEAVEAADVETVGGLLAQRLGRVPLPGAVAEVAGLRLRAEGGKDARGRIRITTVLVEQLDRPDDDTTATPTSLESTG
>NZ_CP053564.1|WP_172159631.1|3373067_3374297_+|L-2-hydroxyglutarate-oxidase
MTTPTFDVVVVGGGIVGLATAHAVARTGRSVAVVEREPRLANHQTGHNSNVIHSGLYYAPGGLKARLAVAGCAETVAFCREHDLPHQVCGKLVVATEPEELPRMAELVRRGAANGVEVTELDQAGMRRYEPNVRGIAALHVPSTGITDYRLIAEKLGELVVKEGGEVHTGRAVTQIVRRGADVVVRTERGDLLGTQVVVCGGLRCDELAVASGADPGIRIIPFRGEYSGFSDRAAALVKGLIYPVPDPAFPFLGVHATRGIDGHVHAGPNAVLALAREGYSWGTVKPKEFLSTIAYPGMLRIARTHWKYGFGEMHRSLSKKAMVKQIQRMLPDVQASDLSPAGAGVRAQAVKRDGTLVDDFLFVDQGSGAGSVLHVLNAPSPAATAALPIGREILERLTGERIAPLGAA
>NZ_CP053564.1|WP_172159633.1|3374370_3375294_+|GTPase-Era
MRFADVPDGYRSGFACFVGRPNAGKSTLTNALIGQKIAITSSRPQTTRHAIRGILHRPDAQLIVIDTPGLHKPRTLLGSRLNDVVRETWAEVDVVGFCVPADVPVGRGDEFIVNELRGVAHRTPVIGVVTKTDLAEPEQVLARLTELSQLMEFAEIVPCSAKDGYQTQLVADLLVKRLPEGMPLYPDGDLTDEPEEILVAELIREASLEGVRDELPHSIAVVIEEMAPRERHPKAEPMLNITANIYVERSSQKGIVIGKGGERLRQVGTDSRRQIEALLGTKVFLDLHVKIAKDWQRDPRQLRKLGF

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Crispr_ID: NZ_CP053564_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053564_4

4760026-4760241

Orphan

Consensus_repeat	Method
CCGCGTTCCGCGGAACGC	CRT

3 spacers

The CRISPR arrays of NZ_CP053564_4

>merge|NZ_CP053564|4|4760026-4760241|CRT
CCGTGTTCCGCGGAACGCGCTCGGGACGTGGGAACGCGTTCCGCGGAACGCTGGCAGACCGCCGAGCTGCGTTCCGCGGAACGCTTGACGACCGCCTCCCCGGGTTCCGCGAAACGCTCACACGGGGCCGGTTCGCGTTCCGCGGAACGCTCGCGCAGGGCCAGAACGCGTTCCGCGGAACGCTGGCTGAGCACGTGCCCGCGTTCCGCGGAACGC

>NZ_CP053564|4|2|4760026-4760241|CRT
CCGTGTTCCGCGGAACGC	GCTCGGGACGTGGGAACGCGTTCCGCGGAACGCTGGCAGACCGCCGAG
CTGCGTTCCGCGGAACGC	TTGACGACCGCCTCCCCGGGTTCCGCGAAACGCTCACACGGGGCCGGT
TCGCGTTCCGCGGAACGC	TCGCGCAGGGCCAGAACGCGTTCCGCGGAACGCTGGCTGAGCACGTGC
CCGCGTTCCGCGGAACGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053564.1\|WP_172168941.1\|4769779_4770280_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NZ_CP053564.1\|WP_172161931.1\|4763192_4764152_+\|lipase	unknown	unknown	gnl\|CDD\|334634
NZ_CP053564.1\|WP_172161933.1\|4764138_4765560_-\|aspartate-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|215475
NZ_CP053564.1\|WP_172161921.1\|4755823_4756786_-\|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
NZ_CP053564.1\|WP_172161939.1\|4770289_4770631_-\|Lsr2-family-protein	unknown	unknown	gnl\|CDD\|378714
NZ_CP053564.1\|WP_172168929.1\|4753733_4754402_-\|AIM24-family-protein	unknown	unknown	gnl\|CDD\|224924
NZ_CP053564.1\|WP_172161919.1\|4754491_4755139_-\|AIM24-family-protein	unknown	unknown	gnl\|CDD\|376704
NZ_CP053564.1\|WP_172161927.1\|4761763_4762645_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212494
NZ_CP053564.1\|WP_172161913.1\|4749905_4750802_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237171
NZ_CP053564.1\|WP_172161937.1\|4768403_4769702_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053564.1\|WP_172161923.1\|4756941_4757940_+\|ketoacyl-ACP-synthase-III	unknown	unknown	gnl\|CDD\|238426
NZ_CP053564.1\|WP_172161929.1\|4762718_4763150_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379279
NZ_CP053564.1\|WP_172168935.1\|4758667_4759879_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP053564.1\|WP_172168932.1\|4755150_4755744_-\|AIM24-family-protein	unknown	unknown	gnl\|CDD\|376704
NZ_CP053564.1\|WP_172161917.1\|4751734_4753714_+\|alpha-amylase	unknown	unknown	gnl\|CDD\|200463
NZ_CP053564.1\|WP_172161925.1\|4757936_4758668_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|132997
NZ_CP053564.1\|WP_172161941.1\|4770593_4771244_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP053564.1\|WP_172168938.1\|4765578_4767096_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|169098
NZ_CP053564.1\|WP_172161935.1\|4767231_4768386_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340882
NZ_CP053564.1\|WP_172161915.1\|4750888_4751698_+\|intradiol-ring-cleavage-dioxygenase	unknown	unknown	gnl\|CDD\|239540

Protein	Function_ID	Function_description	E-value
NZ_CP053564.1\|WP_172168941.1\|4769779_4770280_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	8.94209e-25
NZ_CP053564.1\|WP_172161931.1\|4763192_4764152_+\|lipase	gnl\|CDD\|334634	pfam01674, Lipase_2, Lipase (class 2). This family consists of hypothetical C. elegans proteins and lipases. Lipases or triacylglycerol acylhydrolases hydrolyze ester bonds in triacylglycerol giving diacylglycerol, monoacylglycerol, glycerol and free fatty acids. Lipase EstA is a extracellular lipase from B. subtilis 168.	1.18022e-15
NZ_CP053564.1\|WP_172161933.1\|4764138_4765560_-\|aspartate-aminotransferase-family-protein	gnl\|CDD\|215475	PLN02880, PLN02880, tyrosine decarboxylase.	6.36144e-154
NZ_CP053564.1\|WP_172161921.1\|4755823_4756786_-\|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	4.57824e-51
NZ_CP053564.1\|WP_172161939.1\|4770289_4770631_-\|Lsr2-family-protein	gnl\|CDD\|378714	pfam11774, Lsr2, Lsr2. Lsr2 is a small, basic DNA-bridging protein present in Mycobacterium and related actinomycetes. It is a functional homolog of the H-NS-like proteins. H-NS proteins play a role in nucleoid organisation and also function as a pleiotropic regulator of gene expression.	8.83452e-54
NZ_CP053564.1\|WP_172168929.1\|4753733_4754402_-\|AIM24-family-protein	gnl\|CDD\|224924	COG2013, COG2013, Uncharacterized conserved protein [Function unknown].	1.12534e-11
NZ_CP053564.1\|WP_172161919.1\|4754491_4755139_-\|AIM24-family-protein	gnl\|CDD\|376704	pfam01987, AIM24, Mitochondrial biogenesis AIM24. In eukaryotes, this domain is involved in mitochondrial biogenesis. Its function in prokaryotes in unknown.	4.95034e-34
NZ_CP053564.1\|WP_172161927.1\|4761763_4762645_+\|SDR-family-oxidoreductase	gnl\|CDD\|212494	cd08946, SDR_e, extended (e) SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.65783e-33
NZ_CP053564.1\|WP_172161913.1\|4749905_4750802_-\|hypothetical-protein	gnl\|CDD\|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	5.57217e-07
NZ_CP053564.1\|WP_172161923.1\|4756941_4757940_+\|ketoacyl-ACP-synthase-III	gnl\|CDD\|238426	cd00830, KAS_III, Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP. KASIII initiates this process by specifically using acetyl-CoA over acyl-CoA.	2.96863e-75
NZ_CP053564.1\|WP_172161929.1\|4762718_4763150_+\|ATP-binding-protein	gnl\|CDD\|379279	pfam13581, HATPase_c_2, Histidine kinase-like ATPase domain.	2.46254e-26
NZ_CP053564.1\|WP_172168935.1\|4758667_4759879_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	4.16939e-31
NZ_CP053564.1\|WP_172168932.1\|4755150_4755744_-\|AIM24-family-protein	gnl\|CDD\|376704	pfam01987, AIM24, Mitochondrial biogenesis AIM24. In eukaryotes, this domain is involved in mitochondrial biogenesis. Its function in prokaryotes in unknown.	4.37252e-40
NZ_CP053564.1\|WP_172161917.1\|4751734_4753714_+\|alpha-amylase	gnl\|CDD\|200463	cd11324, AmyAc_Amylosucrase, Alpha amylase catalytic domain found in Amylosucrase. Amylosucrase is a glucosyltransferase that catalyzes the transfer of a D-glucopyranosyl moiety from sucrose onto an acceptor molecule. When the acceptor is another saccharide, only alpha-1,4 linkages are produced. Unlike most amylopolysaccharide synthases, it does not require any alpha-D-glucosyl nucleoside diphosphate substrate. In the presence of glycogen it catalyzes the transfer of a D-glucose moiety onto a glycogen branch, but in its absence, it hydrolyzes sucrose and synthesizes polymers, smaller maltosaccharides, and sucrose isoforms. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NZ_CP053564.1\|WP_172161925.1\|4757936_4758668_+\|glycosyltransferase	gnl\|CDD\|132997	cd00761, Glyco_tranf_GTA_type, Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold. Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.	1.59495e-19
NZ_CP053564.1\|WP_172161941.1\|4770593_4771244_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.10096e-12
NZ_CP053564.1\|WP_172168938.1\|4765578_4767096_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|169098	PRK07786, PRK07786, long-chain-fatty-acid--CoA ligase; Validated.	0
NZ_CP053564.1\|WP_172161935.1\|4767231_4768386_+\|MFS-transporter	gnl\|CDD\|340882	cd17324, MFS_NepI_like, Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily. This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.17509e-31
NZ_CP053564.1\|WP_172161915.1\|4750888_4751698_+\|intradiol-ring-cleavage-dioxygenase	gnl\|CDD\|239540	cd03457, intradiol_dioxygenase_like, Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the extradiol-cleaving enzymes which break the C2-C3 or C1-C6 bond and utilize Fe2+ and Mn+. The family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases. The specific function of this subgroup is unknown.	1.26565e-61

>NZ_CP053564.1|WP_172168935.1|4758667_4759879_+|cytochrome-P450
MCGSAARERRSWLQARSPLTTGTWERRVQLGAHPVAYPLVRALARIGPVVRVPRVGVVVSDAALARAVLTDTASFAKTGPGSPAALWTPVVGPSVLLNMEGAEHAALRRALADLFTPSAVAALCARVLAGPCAELRDRLVTGEAVDLVPVAQQAAGAVIAGLVGLDARDAAGPAFAAATAVTGMVRLARPELTARQVARGRAALAGITAPAADAYRDGDPATVPGRMRELGLTEREALGAVAAFALTGTETVVSFLPRLVALLHDARLLDALAADRGRVDACVEEALRVTVPSPVMLRRVAAPARIGTVEVVPGDRVVIATVSAARAYGGFDPDRPHPPAVRRLWFGAGPHFCLGMPLATAQVRLVLDAVLDAHGERPLGLVRRRVARRVLIPAYREMVVRGG
>NZ_CP053564.1|WP_172161925.1|4757936_4758668_+|glycosyltransferase
MNLWVVVPAFDEAAGIGATLDALAAQRDRDFRLVVVDNASTDGTAEVVRAHGLPAEIVVEPQRGTGAAADTGMRWAITAGATHLARTDADCLPAPDWTARVKVAFADLDLVAGRLLPRRDEGLPAWQRGVLVGAVGVAGTFGRFRPGNRVAGALGPYVMSAGCNMAITAELYERAGGFPRTRIQDVHEDRALVNAVRPLTTRYGARRDVVVRGSSRRVRAWGLVRTLGWYADHRYRPAHVDIR
>NZ_CP053564.1|WP_172161923.1|4756941_4757940_+|ketoacyl-ACP-synthase-III
MGARIAGVEVHLPGHRVGTAEVEARIGASGWSPPAGMVHRLTGITARHVAGDHEQASDLAVAAARKLLAATGTAAEDVDLLLFASASQDMVEPATAHIVAAKLELSCPVMDVKNACNSVLNGMEVADALIATGRYGRVLVVSGETPSRAVRWDVEGIRGFLRAFPGYTLSDAGAAVLLVPGDADSGILGSGFTADSRHWEAGTLAAGGSLHPRDVEHTYFAMDSARLKAAFLAVGTGILDDTLARLDLTWDDMAVVAVHQVSLPYLEVFARGAGVPADKLVVTVAEHGNVASASLPLQLVTARELGRCGPGDLVALVGLAGGVSLGITVVRL
>NZ_CP053564.1|WP_172161921.1|4755823_4756786_-|iron-siderophore-ABC-transporter-substrate-binding-protein
MSHRSLLTRAAAALAVGAAVLAGCASPAETPATPAAPAADGAYPVTIPNAYGETTIPAEPTRVVAVGFNEADFLLALGVVPVGVRDFIGEYDETARPWAQEALAGAQPADVGGTEINVEAIAALEPDLIMGVYSFMDRATYDALSAIAPTVGPVSADGTVGWEEQTRITGTALGREEQAADAIATVEQAFADARAAHPGFAGREVTIDLPVNGVAYLLGADDLRSSVFTGVGLTVPEATTELGPETIGQLDSDALVVLGATAEDMAGDPLFQSLPVVQEGRTIFTGGYEEDFNGAIGFGSPLSLPYAVELITPQLAAVLG
>NZ_CP053564.1|WP_172168932.1|4755150_4755744_-|AIM24-family-protein
MLEIDLAGDAVRASTGSMIAYTGDVTFKNAGMGGGDGLMAGLKRRAAGESVALMHCTGHGTVWFAKDAMEVLIVELNGDTLRVESEQLLALSDKLKTDVAFAGVRGASSGQGLFTTTVTGYGTVALLSAGGPPIALEVSPQFPLVVDPDAFVASQGQLNQSFVTDVSWRNLVGESSGEAFSLRFDGSGVVYIQPEER
>NZ_CP053564.1|WP_172161919.1|4754491_4755139_-|AIM24-family-protein
MPFEQVNSKVISVGVTHGREVLARKGAMLAYTGDVHFSPVHMGPGGAGGMVGRMVSGEQVAMMVAQGNGTVHYGYRGLYVTIIELDGSGPLSVEADRLVAHDAALQSTVVFLGSQGGIRGAVRGAVSGQGLFTTQLHGYGTAAVLSHGGTIAIPVGGRPVAVDPQAYVAHIGQVNVDIAASVGWRDAVGRGSGEAVQLKCTGQGTVYVQASEQKL
>NZ_CP053564.1|WP_172168929.1|4753733_4754402_-|AIM24-family-protein
MQTGRMIAYYPAPHSQGIRFEPLTGASVGGMVATRFSAPLYTRDWVVATGAGHLILGDRGYDINSYDLDDGNLTLRAANLLAFDSTLELKQSIVPGFLTLIGTGKFLASSSGPVIFAEPPIRVDPEALVGWADCPSPSHHYDAGWMSGFLQGAMGMLGVQSGEERQFDFTGAGTVLIQSSENTMGDPHQLRQLEGQVGTLGVSGLQRMQQVVAQRLAAEQQR
>NZ_CP053564.1|WP_172161917.1|4751734_4753714_+|alpha-amylase
MWPVIATPPARSDAERARDAAAALARLRPGVVDEAGRVLEPSDAVGFVARLDLWFADLHAPLAALYPDAEALAERLVLLALRSAAQRPADLRAVDRRREIDPRWFQHQRMVGYVAYTDRFAGTLAALPGRLDHLAELGVTYLHLMPLLRPREGANDGGYAVADYRAVDPRLGTMDDLSALAAALRARDMSLCVDLVLNHTAREHPWAQGWLAGDPAYDGFYLAFPDRTLPDAFEETVVDVFPDQAPGSFTHVPGTGWVWTTFFDYQWDLDYANPAVLTAMTDTILWLANRGVEIFRMDAVPFMGKRVGTPCINQPEVHDIVQAMHAAVKLAAPATVFKAEAIVAPDELVAYLGAHERYRPECELAYHNQLMVVLWSSLATKDARLAVQSLRRLRPIPGETSWATYVRCHDDIGWAVGDVDARAVGYDPFAHRDFLNAFYAGEFPLSFARGARFGENPETGDARISGTAAALCGISDARERGDAHALELGVRRLVLLHAVAFAWGGVPLLYMGDELAQGNDTSYVDDPALAADNRWMHRPYFDDAAAAHRHDPATVEGRVFGWMRALAQARASQQALHAAAGSAVLEVDSPHVLAWWRRHPRSGNFVGMANMAEHPVTVDAHVLDGLGPLETVLSSDGPLLVQDGRLVVPGLGFVWLAEP
>NZ_CP053564.1|WP_172161915.1|4750888_4751698_+|intradiol-ring-cleavage-dioxygenase
MSDHDDHDDDHHDGDHDLGLAHDLPRLVGRRRLLGLLAGAGALTLAGCAAAATGTTASTTGAATGEIPEETAGPFPGDGSNGPNVLTESGVVRSDIRSSFGSLSGTAPGVPLTITLALVDAASGAALPGGTVYLWHCDRDGRYSLYDVADQNYLRGVQEADANGRMTFTTVFPAAYSGRWPHAHFEIYPDLAAATTPDNATVTSQLALPQDVCEAVYATDGYASSVRNLARTSLERDTVFSDGYASQLATVTGDVTTGLAATLTVGVDA
>NZ_CP053564.1|WP_172161913.1|4749905_4750802_-|hypothetical-protein
MDIDELADALYSAPPADFVATRDEAVKAARERGDKEFATAAARLRRPTRAAWLANLLARHRREQLDGLLGLAGSLADAQRTLDGPALRTLSTRRRQLVAAMAREAGRLAREAHESVNDSLLRELGDILEAALADPVVADEVRSGRLTRTISYSGFGPESDPDAVAARVAAAPAPAPSPAEQDAPAEEPAEDPAEVARREREREERRRDLADAEELEAAARERRDAAEAEHERAAQEHEQARERVATLTAELEAAQRHERESAVRNREAAQHARAAAREAGTAATRTARARARLDDAEP
>NZ_CP053564.1|WP_172161927.1|4761763_4762645_+|SDR-family-oxidoreductase
MRLAVTGAAGFVGSAVVAAARARGWEVHALTRREWDVTTGPMPHPPPVDAVVHAAAAVTDWGDPAPVWAANLHGTRHVAGTFPGARLVHVSTASVYDPFVPTVDAPESAGPAARHLTPYGASKAAAERLLAGRPDTVVLRPHAVYGPGDPTLLPRILGAVRGRTLVVAGDGGARHTLTAVATLAQACLLGCTGPPGTYNVGDAAPVTLDAALTALLHARGLDVTVRHVPVGLAWALAGAAEGAFRALRRPAPPRLTRFAVSQLGVERTLDLTAARTLLGLDPPPTSFSGADEW
>NZ_CP053564.1|WP_172161929.1|4762718_4763150_+|ATP-binding-protein
MSSPVPGHVEFVHRSWPADPAQLTVIRHELAGWLAPLSLTDDETADVVLAVDEAAANAVRHAYGPDESGAVELTLWTEAADAEGPATLCIEVVDHGHWQPPVDQPTEGGRGIPLMSTMSESVLIHYDERGSRVLLRHRIPDAA
>NZ_CP053564.1|WP_172161931.1|4763192_4764152_+|lipase
MGRGQRARWVGGAALVAALVAGLAVVPASAQEADLPVPYGALATLAAEAAAPGSSPPGSNDDDCEPTAEHPDPVVLVHGLGANRTVNWQTMSPLLANEGYCVFALTYGTALAGEQVGGLRPMEQSAEELAAFVDGVLAATGAERVDLVGHSEGTLMPQYWLQFLGGNEVVDDYVAVTPLYDGTLADPLPVDALVDALGVRDAAGAPVALACGSCPQFVSGSDYLDRMAAAGTRVEGIDYTTVMTRYDQLVVPYTSGVLEGATNIVVQDGCEIDFSDHLSIIFSERTGQIILNALDPEDAQDLPCRPVAPLLGNELISVK
>NZ_CP053564.1|WP_172161933.1|4764138_4765560_-|aspartate-aminotransferase-family-protein
MSDLDPEEFRRLGHAVVDWVAGYRAGIGEHPVRAQVEPGWVRERMPALPEQPQPFDALLAELDRVVVPATTHWQAPGFFGYFPANASLHSVLGDLLSGGLGVQGMLWSTSPAATEVEQVLLDGLADALGLDPAYTWAGGGGGTIADSASSAALVALLAALHRTSGGAWRERGVDGTERVYVTAETHSSLAKAVRVAGLGAAALRIVPPSPGSLAMSAQAFAEMAAEDVAAGLRPVLVCPTIGTTGTGAVDPVREIALAAREHGTPGREIWVHVDAAWAGVAALCPEHRDVIDGVELADSFCTDAHKWLLTAFDASLLWVRDAAALPAALSITPEYLRNSATDSGEVVDYRDWQVPLGRRFRALKLWSVLHGFGLEGVRAHLRGHVALAAELESWIVAEPGFELAVPRSLSLVCLRLSAGDEATRALLERVNATGRVLLTHTVVDGRYVIRVAIGSVATEREHVEELWGLLTSR
>NZ_CP053564.1|WP_172168938.1|4765578_4767096_-|long-chain-fatty-acid--CoA-ligase
MTMSDLVARFARTTPDRVALRDGDLTLTWAQTHERVSRMASALTRAGVVPGDRVAVLALNSVPHLEAMAAVLRVGAICVPVNFRLVAAEVAYVLGDSGASVVIADDTFAPLAQAAGASTVVTIGAGYEDLLAAGSPEHAELAVDDRAPAFIMYTSGTTGRPKGAVLSHRNLYLHAFSNLVHAGVSGPGVGMSGAPLFHIAGTSGYYNTLVAGGTTVLTPSGGFDPAGMVDLLERERVTSVFFVPAQWAAIVALPGIAERDLSALQRAIWGAAPASTTLLRTMIATFPQAEVVTAFGQTECSPVTCMLGGEDSIRKIGSIGKPILNVEVRVVDEDMRDVAPGEVGEIVYRGPTVMSGYWNKPEETAEAFRGGWFHSGDLVRADDEGYLYVVDRKKDMIISGGENIYCAEVENTLAAHPKVAEVAIIGVADERYGEAPLAVIAPRDPADPPTAADIEAFSREHLAAYKRPRDVVIVDALPRNPSGKVLKTALRTQYGATAVVSAPAV
>NZ_CP053564.1|WP_172161935.1|4767231_4768386_+|MFS-transporter
MTTGLDRRLRLLQAAALTSTCDRFAIAPLLVVISLDLGASLAAVATVASVYFLAYGLMQPVWGLVSDRIGRVRVMRIALVGAALGGVGSVLAPDLLTLGITRAVAGGSFAALIPSTLVYVGDAWPVAVRQRPLSDVLAASSLGVAAATAGAGLLADLVGWRAVPAATAAAAVVLWFALARLPEPDRELTAGNPWQSLRGVVRTPWALAVLALAFAEGVVVLGVLTFLAPAAQSLGTSATVAGLVAAGYGVGALAWSRLVRRLVGRVPPAGLAAIGGTFLVAAWIVPWVAVNLVTITVAGVLVGGAWAFLHSTLQTWVTEVVPAERASAVALFAASLFLGSAAGTALFAPLAEAGSYPLVFGLAVAAAVPVAVLSTVGRRAYART
>NZ_CP053564.1|WP_172161937.1|4768403_4769702_+|hypothetical-protein
MDVTTPVRRGTRWDLLAVAAVAGLVVAAHVVGEVLKAGGTDIFLGLPPLLAVHLPHAGPGTPVALVVAVAVVVRGPDLARRLAWRPLLLAAYAASALWTVSLALVDGWTRGVVERLTSDQEYLWDVPRVTDVPATLRTFTDFILPGADTWVTHVGAHPPGVLLLYVLLDRVGLGGGGASGVVTMLVGASACVAVAVALRALGAEETARAALPFGVLFPGAVWVGVSADGMFAAVLAWGVALLAFGAAGERVLPSVAGGVLLGSCLYLSYGLVLGGLVPLAVLGVTRSWRAGLAAAAGVALVVAAFTLAGFWWFDGFARVQVIYALSVAATRPYSYFVWANLAALALALGPAVVAGLRRLDLPRPAVWLVVAAAAAVLLADLSGLSKAEVERIWLPFAVWLVVACARLPHARAWLAAQAALALAVNHLLLTVW
>NZ_CP053564.1|WP_172168941.1|4769779_4770280_+|GNAT-family-N-acetyltransferase
MLRRWALDEVDELYRTAADSLTHLAPWMAWAAHGYSDADARHHIEQVHADWAERRGYGYAIRLADGTLVGACGMTDRIGPGGMEIGYWLHPAHTGNGYVTAAAAALTAEAFRIGADRVEIVHDVANARSGAVPRRLGFTEVARRPPQEERTSAEAGEDVVWRRTAP
>NZ_CP053564.1|WP_172161939.1|4770289_4770631_-|Lsr2-family-protein
MAKHTTVTLVDDIDGSEADESVEFAIDGKSYEIDLSTANSSRLRDALAPFVSAARRAGGRRSSGGSATSAPSRPSTDREQNQAIREWAVAQGMKISERGRIPSNVLEAYHQNH
>NZ_CP053564.1|WP_172161941.1|4770593_4771244_+|winged-helix-turn-helix-transcriptional-regulator
MSSTRVTVVCFATHVPFSGVLNCSAVTINDVRWHCRSGSPFWSGSRNQCSLDRRDGCYRRGVNADRDELVRLLQAYAGEAERLSQVFAERHALHATDLAALLAVMQADRAGDPLTPGRLGRHLGLSSGATTAVVDRLERADHVRRARDDRDRRRITLHYGAAADQVASAFFGPLGARMEEVLAGYDAAELAAARRFLGDATEMVRDYRQAVTGDPV

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Crispr_ID: NZ_CP053564_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053564_6

5011754-5011823

Orphan

Consensus_repeat	Method
CCGGGTGGTCGTGCGTTCCGCGGAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP053564_6

>merge|NZ_CP053564|6|5011754-5011823|CRISPRCasFinder
CTGGACCGGTGCGCGTTCCGCGGAACGCAGCTGGCCGAGGCGGCGCGGGCACGGGAGCGTTCCGCGGAAC

>NZ_CP053564|6|4|5011754-5011823|CRISPRCasFinder
CTGGACCGGTGCGCGTTCCGCGGAAC	GCAGCTGGCCGAGGCGGC
GCGGGCACGGGAGCGTTCCGCGGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053564.1\|WP_172162346.1\|5018120_5018942_-\|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	unknown	unknown	gnl\|CDD\|234823
NZ_CP053564.1\|WP_172162328.1\|5002286_5003888_-\|polyprenol-phosphomannose-dependent-alpha-1,6-mannosyltransferase-MptB	unknown	unknown	gnl\|CDD\|274589
NZ_CP053564.1\|WP_172169045.1\|5010280_5011198_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366009
NZ_CP053564.1\|WP_172162336.1\|5008138_5009401_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|131034
NZ_CP053564.1\|WP_172162350.1\|5023876_5026813_-\|formate-dehydrogenase-subunit-alpha	unknown	unknown	gnl\|CDD\|225918
NZ_CP053564.1\|WP_172162344.1\|5017014_5018046_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP053564.1\|WP_172162330.1\|5004731_5006159_+\|Fe-S-cluster-assembly-protein-SufB	unknown	unknown	gnl\|CDD\|131035
NZ_CP053564.1\|WP_172162332.1\|5006155_5007337_+\|Fe-S-cluster-assembly-protein-SufD	unknown	unknown	gnl\|CDD\|273908
NZ_CP053564.1\|WP_172162348.1\|5018941_5020855_-\|molybdopterin-biosynthesis-protein	unknown	unknown	gnl\|CDD\|237732
NZ_CP053564.1\|WP_172169051.1\|5014571_5015534_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP053564.1\|WP_172169054.1\|5020890_5022108_-\|molybdopterin-molybdenumtransferase-MoeA	unknown	unknown	gnl\|CDD\|237732
NZ_CP053564.1\|WP_172162334.1\|5007362_5008124_+\|Fe-S-cluster-assembly-ATPase-SufC	unknown	unknown	gnl\|CDD\|223473
NZ_CP053564.1\|WP_172169048.1\|5013687_5014428_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP053564.1\|WP_172169039.1\|5003886_5004735_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225222
NZ_CP053564.1\|WP_172162340.1\|5012239_5013691_-\|beta-glucosidase	unknown	unknown	gnl\|CDD\|274539
NZ_CP053564.1\|WP_172169042.1\|5009884_5010232_+\|metal-sulfur-cluster-assembly-factor	unknown	unknown	gnl\|CDD\|225062
NZ_CP053564.1\|WP_172162327.1\|5001353_5002277_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP053564.1\|WP_172162342.1\|5015545_5016868_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270303
NZ_CP053564.1\|WP_172169057.1\|5022139_5023846_-\|NAD(P)H-dependent-oxidoreductase-subunit-E	unknown	unknown	gnl\|CDD\|224806
NZ_CP053564.1\|WP_172162338.1\|5009402_5009846_+\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	unknown	unknown	gnl\|CDD\|273918

Protein	Function_ID	Function_description	E-value
NZ_CP053564.1\|WP_172162346.1\|5018120_5018942_-\|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	gnl\|CDD\|234823	PRK00724, PRK00724, formate dehydrogenase accessory sulfurtransferase FdhD.	4.22212e-118
NZ_CP053564.1\|WP_172162328.1\|5002286_5003888_-\|polyprenol-phosphomannose-dependent-alpha-1,6-mannosyltransferase-MptB	gnl\|CDD\|274589	TIGR03459, crt_membr, carotene biosynthesis associated membrane protein. This model represents a family of hydrophobic and presumed membrane proteins found in the Actinobacteria. The genes encoding these proteins are syntenically associated with (found proximal to) genes of carotene biosynthesis ususally including phytoene synthase (crtB), phytoene dehydrogenase (crtI) and geranylgeranyl pyrophosphate synthase (ispA).	7.40177e-62
NZ_CP053564.1\|WP_172169045.1\|5010280_5011198_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|366009	pfam00296, Bac_luciferase, Luciferase-like monooxygenase.	7.70873e-33
NZ_CP053564.1\|WP_172162336.1\|5008138_5009401_+\|cysteine-desulfurase	gnl\|CDD\|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_CP053564.1\|WP_172162350.1\|5023876_5026813_-\|formate-dehydrogenase-subunit-alpha	gnl\|CDD\|225918	COG3383, COG3383, Uncharacterized anaerobic dehydrogenase [General function prediction only].	0
NZ_CP053564.1\|WP_172162344.1\|5017014_5018046_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	7.25243e-96
NZ_CP053564.1\|WP_172162330.1\|5004731_5006159_+\|Fe-S-cluster-assembly-protein-SufB	gnl\|CDD\|131035	TIGR01980, UPF0051_protein_slr0074, FeS assembly protein SufB. This protein, SufB, forms a cytosolic complex SufBCD. This complex enhances the cysteine desulfurase of SufSE. The system, together with SufA, is believed to act in iron-sulfur cluster formation during oxidative stress. Note that SufC belongs to the family of ABC transporter ATP binding proteins, so this protein, encoded by an adjacent gene, has often been annotated as a transporter component. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_CP053564.1\|WP_172162332.1\|5006155_5007337_+\|Fe-S-cluster-assembly-protein-SufD	gnl\|CDD\|273908	TIGR01981, UPF0051_protein_Rv1462/MT1509, FeS assembly protein SufD. This protein, SufD, forms a cytosolic complex SufBCD. This complex enhances the cysteine desulfurase of SufSE. The system, together with SufA, is believed to act in iron-sulfur cluster formation during oxidative stress. SufB and SufD are homologous. Note that SufC belongs to the family of ABC transporter ATP binding proteins, so this protein, encoded by an adjacent gene, has often been annotated as a transporter component. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	1.5343e-73
NZ_CP053564.1\|WP_172162348.1\|5018941_5020855_-\|molybdopterin-biosynthesis-protein	gnl\|CDD\|237732	PRK14498, PRK14498, putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional.	0
NZ_CP053564.1\|WP_172169051.1\|5014571_5015534_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	5.62758e-84
NZ_CP053564.1\|WP_172169054.1\|5020890_5022108_-\|molybdopterin-molybdenumtransferase-MoeA	gnl\|CDD\|237732	PRK14498, PRK14498, putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional.	1.02451e-126
NZ_CP053564.1\|WP_172162334.1\|5007362_5008124_+\|Fe-S-cluster-assembly-ATPase-SufC	gnl\|CDD\|223473	COG0396, sufC, Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones].	2.19631e-143
NZ_CP053564.1\|WP_172169048.1\|5013687_5014428_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	3.00959e-71
NZ_CP053564.1\|WP_172169039.1\|5003886_5004735_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	2.69083e-54
NZ_CP053564.1\|WP_172162340.1\|5012239_5013691_-\|beta-glucosidase	gnl\|CDD\|274539	TIGR03356, BGL, beta-galactosidase.	0
NZ_CP053564.1\|WP_172169042.1\|5009884_5010232_+\|metal-sulfur-cluster-assembly-factor	gnl\|CDD\|225062	COG2151, PaaD, Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only].	4.6221e-33
NZ_CP053564.1\|WP_172162327.1\|5001353_5002277_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	3.95791e-84
NZ_CP053564.1\|WP_172162342.1\|5015545_5016868_-\|extracellular-solute-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.96995e-29
NZ_CP053564.1\|WP_172169057.1\|5022139_5023846_-\|NAD(P)H-dependent-oxidoreductase-subunit-E	gnl\|CDD\|224806	COG1894, NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion].	1.62398e-129
NZ_CP053564.1\|WP_172162338.1\|5009402_5009846_+\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	gnl\|CDD\|273918	TIGR01994, Iron-sulfur_cluster_assembly_scaffold_protein_IscU, SUF system FeS assembly protein, NifU family. Three iron-sulfur cluster assembly systems are known so far. ISC is broadly distributed while NIF tends to be associated with nitrogenase in nitrogen-fixing bacteria. The most recently described is SUF, believed to be important to maintain the function during aerobic stress of enzymes with labile Fe-S clusters. It is fairly widely distributed. This family represents one of two different proteins proposed to act as a scaffold on which the Fe-S cluster is built and from which it is transferred. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	2.61215e-59

>NZ_CP053564.1|WP_172169045.1|5010280_5011198_+|LLM-class-flavin-dependent-oxidoreductase
MLRREVPPEHTVAYARGVEALGFDELWLVEDCFYAGAVAAGAVALAATERIEVGLGVLPAVFRNPAATALEVAALARMFPGRLRPGLGHGVTGWMRQIGAFPSSQLAALEETTSALRALLRGERVTVDGRHVHLDDVVLEFPPPVVPPVATGVRGPRSLRVSGRVADGTVLTELSVPSYVRWARERIDEGRAEAGRTDPHHLTVYAYAAPDRAALLPLVADGLRGGGGAGQWGELADPIASWREAGGSGDLPDAWLDALTVSGDGARGSLAALVEAGADSVVLIPAAEDPDDALAELGALRSVLS
>NZ_CP053564.1|WP_172169042.1|5009884_5010232_+|metal-sulfur-cluster-assembly-factor
MPEPPAPAAGPSIDDLEEAMRDVVDPELGINVVDLGLVYGIQAVDGVATIDMTLTSAACPLTDVIEEQTRSALTGGGQGGLVDDIKINWVWMPPWGPDKITEDGREQLRALGFRV
>NZ_CP053564.1|WP_172162338.1|5009402_5009846_+|SUF-system-NifU-family-Fe-S-cluster-assembly-protein
MQLEQMYQEIILDHYRTPHGAGLREPFDAESFQINPTCGDEITLRVKLDGDTVAEVSHDTLGCSISQASASVLTDLVVGRSVGDSMKILQAFQEMTQGRGKVEPDEDVLGDGVAFAGVAKYPARVKCALLGWMAFKDAVVRTEGEKA
>NZ_CP053564.1|WP_172162336.1|5008138_5009401_+|cysteine-desulfurase
MDVTKIRADFPILARTVRGGRPLVYLDSGATAQRPRQVLDAERSFLEQHNAAVHRGAHQLAEEATDAYESARARIAAFVGADPGEVVFVKNATEGINLVAYAMGNAAGFPGAERFEIGPGDEIVVTDLEHHANLVPWQELCRRTGAVLKWFQVGDDGRLDLGSGSDGGDPITERTKIVAFAHQSNVLGTILPVAELSRRARAVGALVLLDACQSVPHMPVNLTELDVDFAVFSGHKMLGPSGVGVLYGRAELLAAMPPFLTGGSMIEMVRMEGSTYAPPPQRFEAGVPMTSQAVGLAAAVDYLTEIGMDAVHAHEQELTALAIEGLSSVPGVRVIGPATTDDRGGAVAFVVDGVHAHDVGQVLDDRGVAIRVGHHCAWPLHRRFGVAATARASFHVYNTPEEVTALVDGVRAAREFFGVA
>NZ_CP053564.1|WP_172162334.1|5007362_5008124_+|Fe-S-cluster-assembly-ATPase-SufC
MSTLEIKDLHVSIAVDGGTKEILTGVDLTINAGETHAIMGPNGSGKSTLAYAIAGHPKYEVTSGEILLDGADVLAMTVDERARAGLFLAMQYPVEVPGVSTANFLRSAATAVRGEAPKLRTWVKEVKTAMADLEIDAAFAERNVNEGFSGGEKKRQEVLQLSLLKPKFAVLDETDSGLDVDALRVVSAGVNRYREGGETGVLLITHYTRILQHIHPDVVHVFAGGKVVESGGPELADELEKNGYVRFTQPASV
>NZ_CP053564.1|WP_172162332.1|5006155_5007337_+|Fe-S-cluster-assembly-protein-SufD
MSEGRMTETIAGLAPELAGAKKGMGSKPLASASERFTSYDVAAFEVPSGREENWRFTPKRRLRGLWETTEFSAAPEVVVSDGASVETVGRDDARIGEGGIPADRIAAAAWSGFDRATVVTLDGTPEPVTVTVTGPGEGVVAAGHVQIRTTPHTVATVVVVNRGSGTLADNLEVVVADGSTLHLVVTEEWADDAVHAGAHHFSVGRDATLRAVAVQLGGDLVRIVSTVNYRGPGGDAELLGLGYADAEQHLEQRLLVDHGVSHCRSNVLYKNALQGTGAHTVWIGDVLIRAAAESTETFEFNRNLVLTPGARADSVPNLEIETGEIVSAGHASATGRFDDEQLFYLQSRGIPEDAARRLVVRGFFGEILSKITLPDLRERLEALVEAELAVTGV
>NZ_CP053564.1|WP_172162330.1|5004731_5006159_+|Fe-S-cluster-assembly-protein-SufB
MTTAPEALTQEETLATLGRYDFGWADPDAAGATARRGLSADVVADISALKSEPQWMLDFRLKALDMFEKKPMPRWGSDLSGIDFDNIKYFVRSSEKQAATWDDLPADIKNTYDKLGIPEAEKARLVSGVAAQYESEVVYHSIREDLEEQGVIFLDTDTALKEHPEMFREYFGSVIPSGDNKFSALNSAVWSGGSFIYVPPGVHVDIPLQAYFRINTENMGQFERTLIIVDEGAYVHYVEGCTAPIYSSDSLHSAVVEIIVKKGGRCRYTTIQNWSNNVYNLVTKRAKAEAGATMEWVDGNLGSKVTMKYPAVMLMGEYAKGEVLSIAFAGEGQHQDAGAKMTHLAPHTSSTIISKSVARGGGRTSYRGLVRVNPNAHHSRSTVKCDALLVDTISRSDTYPYVDVRNDDVSMGHEATVSKVSEDQLFYLMSRGLTEDEAMAMVVRGFVEPIARELPMEYALELNRLIELQMEGSVG
>NZ_CP053564.1|WP_172169039.1|5003886_5004735_+|winged-helix-turn-helix-transcriptional-regulator
MAGAYRGGPGVKRLTRGGGAFAVSGHIRNTGVVKSTGTPLDGHLPADGRTRESVARLLMEQGPIVAADVAARLGLSSPAVRRHLDALIADGEAEVRDAPRRGPRGRGRPAREYLLTDSGRARFGHGYDDLAVAALRYLVEHGGPDAVEGFAQSRVEQLLGDGVAKVEAAHGSGARVQALADVLTARGYAAQARDGGHGVQLCQHHCPVAHVAAEFPALCEAETHAFAELLGTHVQRLATIARGDSACTTHIPLDLPEVRRMNTTTTPGPRPGATIPRGRQSE
>NZ_CP053564.1|WP_172162328.1|5002286_5003888_-|polyprenol-phosphomannose-dependent-alpha-1,6-mannosyltransferase-MptB
MTAPGVDTTTAPGGPPPAPARDPSRTARLFGLVGSLLMAGGALGSGALPVPNPLFGIRVLSLPSRNATVAIAVTYAGIGMVVLAWLWIGKMLRANGAVAPAPDRTQLARTAVLWAIPLALAPPLFSRDVYSYLAQSATLARGLDPYTLGPAEAFGVDDPLVRSIPTIWRDTGAPYGPFFLVLGRGITALTGNDIVAGVFAHRALALLGVAMIVWVLPKLARRCGLDVGLAMWLGAANPLVLFHLVSGMHNESLMVGLMLVGFEVGLRAGDRWWDPHLLAGGVLIVLASAVKLPALLALGFLGIEWARRRGGRVRDVAVATALYTGIAVLVYAAFGIGTGLGLAWLDALDAPSLIRSWLSISTDFGLLGGQVGIILGGLGDHTDAVLGLTRTAGLVLAALLAGWLMLAVLRGRLDAITGMAAGMAAVVVLSPIVHPWYLLWAVIPLAATKAMPKARRAMLIISGILAIVVPPTGADFNFRAYQLPMSIVAGLLVIALTLLVVRRSLVGRTGVDVDAWPGHVPAGRPKEDRGAPL
>NZ_CP053564.1|WP_172162327.1|5001353_5002277_-|ABC-transporter-ATP-binding-protein
MSSQPAVSVRGLVKRYGRSTAVDGLDLELAPSSVLALLGPNGAGKTTTVEVCTGFARADAGEVRVLGVDPAGAPDALRARIGVMPQGGGAYPGVHAGEMLRVVAACAAHPLDVGWLSGVLGLDACGRTPYKRLSGGQQQRLALACAVVGRPELVFLDEPTAGMDPQGRRLVWDLISALRRDGVAVLLTTHLMEEAEALADDVVIVDHGRVVAHGTPAALTAGEQQELRFRARPGMDLAGLRTALPDGYGAAEPIAGRYLVQGRINPTVLSVITSWCAEQGALADDVQVARRSLEDVFLELTGRELRA
>NZ_CP053564.1|WP_172162340.1|5012239_5013691_-|beta-glucosidase
MTGVTTTQAQPTTLPLTFPPGFLWGSATAAYQIEGAVAEGGRTPSIWDTYAHTPGRIAGGDTGDVADDHYHRFRDDVALMKRLGLTSYRFSVSWSRITPQVTADGLGPVNAEGVAFYSGLVDALLAAGITPAVTLYHWDLPQALEDAGGWASRSTAERFGEYAGVVAAALGDRVRLFITLNEPWCTAYLGYASGVHAPGRTEDAAALAAVHHLNLAHGLGAAAVRRAVPDARVSISLNLVWVRPETPSARDVDAARRVDGLQNRVFLDPLLHGTYPSDVLVDTASVTDWGFVRPGDLDVIAAGGVDVLGVNYYSPTVVRHWTRERPKEYADGHGDGAASPWIACEDVEFPRRPGRKTDMGWGIDPRGMTELLVRMAREHPGLELMVTENGAAFPDVVGADGRVADPDRREYLRTHIAAVHAAIAAGAPVIGYCVWSLLDNFEWAWGYGKRFGIVHVDYDTQERTVKDSALFYADVIRANAVQP
>NZ_CP053564.1|WP_172169048.1|5013687_5014428_-|carbohydrate-ABC-transporter-permease
MIVAASRPMAEMNQTPPPLLPGPDLWSNIVKAVESQDIGLALMNSMIVSGVITVSTVLLCTLAGFAFAKMRFRGRNVLFGIALGTMMIPPSLGVVPLYALMATLGLAGDLSSVILPSLVQCFGVFFMRQYLIQTLPDELLDAAKVDGATSLRTFWSIVLPIARPGMAVLAMLTFMTAWNDFFWPVITLNSSNPTVQVALNNLGSGYVPDTSVIMAGTLVGTLPVIVVFLLLGRQIVGGIIAGAVKG
>NZ_CP053564.1|WP_172169051.1|5014571_5015534_-|sugar-ABC-transporter-permease
MSTPARPVPGERTPPPGSGTPRRSWRTRLFQAEERTAPYVYVAPFFLLFAAFGLFPLVQTAWISLHSYKLGSEMKWLGLENYVWLFSNPDFYNSLWKTFTIGVLSTVPQLMIALGLAHLLNYRMRGRTFFRVAMIMPYATSVAAAALVFAQLFGRDAGAVNWLLGVVGVDAVDWRNGDWTAQLAISIIVIWRWTGYNALIYLAGMQSISQDLYEAAALDGASRWQQFRHVTLPGLRPTILFTAVVSTIGASQLFGEPLIFGGGQPDGGALGQYQTLGLFMYQQGWTYGSLGRAATVAWVTFLLIIVLVLVNTAITRRRQP
>NZ_CP053564.1|WP_172162342.1|5015545_5016868_-|extracellular-solute-binding-protein
MTTTPRTTPRTTRVRTARTTLAAAVAGTLLLAACGGGGGAAADDGTTELTVSLFGTFGYEELGLFDRYEAEHPGVTITYESTQGEDKYWPALQTRLASGSGVADIQGIEVARIADVVANQAELWTDLRNTPAAGSIGNYVEWKEPAATTPDGAVLGLGTDIGPMGICYRSDLLAQAGLPTEPAALSARMTSWEDYVALGREYQAAAPAGSAWMDSAGGFYNAIVSTEQTIYYDQAGTLVHDSNPAVRAAFDTAAAAGQAGLTARLEQFVDPGWDAGFASGSFATIACPSWMIGYIKGKAGDAGSGLWNVTTLPGGAGGNWGGAYLGIPASSENVEEAAELIAWLTAPERQAEVFASAGNFPSTTGGIEMVADATDPWFNGAPIGQIFSTSTANAPVQILGPEDGVIKSAMVEALLSVEANGVAPADAWNSALSTVSNQVS
>NZ_CP053564.1|WP_172162344.1|5017014_5018046_-|LacI-family-DNA-binding-transcriptional-regulator
MSGRDGRGAPTLESVAALAGVSRATAGRVLSGSTKVGPRARDAVLAAAAELHYVTNRAARSLMTRRSDSIAFVVAESEDRFFADPYFSQVLHGAHGVVARHDMQLVFAVVSGDDTERQRFERFALGGHLDGAILVSLHGDDPLPRRLQDAGVPVVLSGRPFAHQARTPLTYVDADNVGGAMAAVRLLAQQGRRRIATITGPLDMAASVDRVDGFRAELAAHDVVDAGSADGDFSIVGGRRAMADLLAADPLIDAVFAANDLMAVGALQAVREAGRRVPEDVAVVGFDDSAIAVSAQPPLTTVRQPMVEMGRTLATLLLDQITHGGEPQAPVILPTEIVRRASA
>NZ_CP053564.1|WP_172162346.1|5018120_5018942_-|formate-dehydrogenase-accessory-sulfurtransferase-FdhD
MGRLSVRRPVVRIGPDGRRRTLDTLAAEEPLELRVDGKPLSVTMRTPGHDVELAHGFLLTEGVLGSASDVLTARYCDSFDDDGRNTYNVLDIALAAGVEPPDASLERNFYTTSSCGVCGKASLDAVRLKTRFSPAADPLVVTPAVLSALPDALRGAQKLFDSTGGLHGAGLFTADGELLVAREDVGRHNAVDKVLGWALLQDRVPAAGTVLMVSGRASFELVQKAVMAGVPLLSAVSAPSSLAVELAQDAGVTLVGFLRGETMNVYSHDARVT
>NZ_CP053564.1|WP_172162348.1|5018941_5020855_-|molybdopterin-biosynthesis-protein
MTRSGPFVSDVPTAEATAAWRAACAAAGCPERTGTEHVPVAGAVGRVLAEPVWAVRSSPAFDSAAMDGIAVRAAETVGAADTTPVLLADFAVVDTGDPMPVGYDAVVMREHVHHTADGRAELRAAVPPYEHVRSIGEDISATELLLPAGHRMRPVDVAAAAAAGAVAPAVHRRPHVVVIPTGDEIRPVGTEPGPGEILDTNSIMLVAQAREAGCTAAATEIVPDDPERITAALRAAAAGADLVVLIAGSSAGRDDHTAGVVAGAGTLAVHGVAVRPGHPVVLGVVEGGTPVLGAPGYPVSAALTFEIFALPLLAALEGAAPRERPSTTARLARKLASVIGSDDWVRVRLGRVGGEVVATPLPRGAGVLTSLVRADGLLVVPAGVEGHHAGERVRVELLRGLAEIARTIVAIGSHDLVLDMAASALRSADPLLTLASSNVGSLGGLVALRDGLCHLAGSHLLDPATGAYTLPYVDRLLGDLDVAVVRLVHRDQGLIVAPGNPLGLTGIDDLVRPGLRYVNRQRGAGTRALLDHELGARGVDPSAVPGYAREEHTHLAVAAAVAAGRADAGMGILAAARAFGLDFVPVAQEPYDLVVRADALDDPLLAPLWALLDDPAFRGGIEALGGYSCAETGRRVR
>NZ_CP053564.1|WP_172169054.1|5020890_5022108_-|molybdopterin-molybdenumtransferase-MoeA
MSGREFFTARTVAEALAGFTPARRTAVETVAAADARHRVPAEPVRAAAALPGFAKSTVDGFAVRAADTYGASEGLPSYLDLAGAVRMGRAPTVAVPPGGAVAIPTGGVLPEGADAVVMVEHTAETMPGTIEVTRPVAPGAGLVRADEDVAAGGVLVRAGRPLRAPDLGLLAAAGVTEIAVHARPRVVILSTGDEVVPPSTREPAPGQVRDATASALAALVADAGGVPELAGIVGDEPGALTAALRGVLPRADLVVVSAGSSVGTRDETAGAIAALGEVWCHGLAIRPGKPTLLAECGGVPVVGLPGNPLSALVVFGLVGVPLVWRLAGAGAPPQPATRARLARDVASAAGRLDVVQVELRDGEAHPVFGPSALLSVLTRADGYVVVPEPATGLAAGTEVIVTLHR
>NZ_CP053564.1|WP_172169057.1|5022139_5023846_-|NAD(P)H-dependent-oxidoreductase-subunit-E
MRARRVPGVEARAGKFPGPSLIPALNAIQARLGWLPREELEELAREARRPRYEIEGLVSFYPHFRTSPPPAVALHACHDLPCFLRGGEERIAELRERFGEGGRDNPGDVELVEVSCLGRCDVAPAVAVNERPAALSDVDDLVAAARAGGVGDAPARERDEPWPNDPYPAGTGVAQRYATLRALRDGEVDAATVIATLKDSGLRGMGGAGFPTGQKWDLVRGAQPGSTKYVICNADESEPGTFKDRQILATQPHLVLEGLLVAMEVVDAQEGWVFIRHEYGPEEHVLRAEIDALRAAGLVGPGRQVDVFVSPGGYILGEETALLECMEGHRGEPRNKPPFPGNYGLHGRPTLINSVETFADVPVIVQRGAQWWADQGLGDSVGWKFFAVSGHVERPDVYCVPMGTTVGALIELAGGVSEGRALGAVQPGGASSNFIGPERLGTALDFGSAAEAGTMLGSGALVVLAEGSDLLAASTNVLRFFRNESCGKCVPCRVGSTKAHELLAGRSELDDDERAQILRLEEAMRKTSICGLGQVALGPVVSVLGLDKGGAAARDHPKPGGEPAQPDR
>NZ_CP053564.1|WP_172162350.1|5023876_5026813_-|formate-dehydrogenase-subunit-alpha
MTTLQEPPAPTSAPTVTATIDGREVTVAEGTTIYDAARRAGVDIPVLCHDERYDPVGVCRMCVVDTGGRVFAAACVRPCEDGMEVVTTSEELDRSRAVLTELLVADQPPIAEDPKQTTTGDNLLLALEQGLGVERGALPCGSGRGHDSSNPVIDVDHDACILCDRCVRACDDIQGNDVIGRTGKGYATRIAFDLDDPMGASSCVTCGECVQACPTGALTNKSIRDIAIRPREELDAVESVCPYCGVGCAITYRVDREQNAISFAEGRDQPGSQSRLCVKGRYGWDYAASPQRLTVPLIRVDAAYPKGALSADVRGEGTGDRATGRGGGDNDRGRGGGGGDRSRKPGDKRGGHRKPGGLVDYDEVLPHFREATWEEALDLVARRLREIHAEGGPESIAGFGSAKCSNEEAYLFQKLIRTGFGTNNVDHCTRLCHASSVAALFEGVGSGAVSTTYGDVVNADVVIITGSNPTANHPVASSFFKQARRRGTKIIYVDPRASTVAEHADIHIQLKPGTDVAFYNAVMHEVIRLGLIDREFIASRTSNYDELARTVADYPPDRAAQITGVDADSIREVARTWGEAGAGVVYWGMGISQHTTGTDNARCLIALCSITGNVGRPGTGLHPLRGQNNVQGASDAGLIPMFYPDYQGVDREATQARFEEAWGTPLNPQRGLTVTEIISSALQPDGGVRGMYMLGENPFLSDPNINKVRKALSALDFLVVQDIFLTETAEFADVILPATSYLEKDGTYTNTDRRVQLGRKVLDAPGQARPDWEIVQDIAQRVGLDWAYGSPSEVFDEMVALMPSYANLAHGNLGSSGKLYPNSDPEHTDGTVVMFVERFNTDDGLAHLVPAQWLPPKELPDGEYPLVLNTGRLLEHWHTGSMTRRSYALDAISPVAEVYMHPKDAAERGMAHGQRVRARSRRGEIELQVRISHREQLGNVFIPFHFREAAANLLTIDEVDPFGKIPEFKFCAVQVEVL

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Crispr_ID: NZ_CP053564_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053564_7

5012080-5012203

Orphan

Consensus_repeat	Method
GCGTTCCGCGGAACGCACCGAACCG	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP053564_7

>merge|NZ_CP053564|7|5012080-5012203|PILER-CR
GCGTTCCGCGGAACGCACGGAACCGCGGTGCCACCCCGGACACCGGCCGGCGCGCGTTCCGCGGAACGCGCACCGGCCGGAGTCGCCGCGGGCACGGCTGCGTTCCGCGGAACGCACCGCACCG

>NZ_CP053564|7|1|5012080-5012203|PILER-CR
GCGTTCCGCGGAACGCACGGAACCG	CGGTGCCACCCCGGACACCGGCCGGCGC
GCGTTCCGCGGAACGCGCACCGGCC	GGAGTCGCCGCGGGCACGGCTGCGTTCCGC
GGAACGCACCGCACCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053564.1\|WP_172162346.1\|5018120_5018942_-\|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	unknown	unknown	gnl\|CDD\|234823
NZ_CP053564.1\|WP_172162328.1\|5002286_5003888_-\|polyprenol-phosphomannose-dependent-alpha-1,6-mannosyltransferase-MptB	unknown	unknown	gnl\|CDD\|274589
NZ_CP053564.1\|WP_172169045.1\|5010280_5011198_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366009
NZ_CP053564.1\|WP_172162336.1\|5008138_5009401_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|131034
NZ_CP053564.1\|WP_172162350.1\|5023876_5026813_-\|formate-dehydrogenase-subunit-alpha	unknown	unknown	gnl\|CDD\|225918
NZ_CP053564.1\|WP_172162344.1\|5017014_5018046_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP053564.1\|WP_172162330.1\|5004731_5006159_+\|Fe-S-cluster-assembly-protein-SufB	unknown	unknown	gnl\|CDD\|131035
NZ_CP053564.1\|WP_172162332.1\|5006155_5007337_+\|Fe-S-cluster-assembly-protein-SufD	unknown	unknown	gnl\|CDD\|273908
NZ_CP053564.1\|WP_172162348.1\|5018941_5020855_-\|molybdopterin-biosynthesis-protein	unknown	unknown	gnl\|CDD\|237732
NZ_CP053564.1\|WP_172169051.1\|5014571_5015534_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP053564.1\|WP_172169054.1\|5020890_5022108_-\|molybdopterin-molybdenumtransferase-MoeA	unknown	unknown	gnl\|CDD\|237732
NZ_CP053564.1\|WP_172162334.1\|5007362_5008124_+\|Fe-S-cluster-assembly-ATPase-SufC	unknown	unknown	gnl\|CDD\|223473
NZ_CP053564.1\|WP_172169048.1\|5013687_5014428_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP053564.1\|WP_172169039.1\|5003886_5004735_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225222
NZ_CP053564.1\|WP_172162340.1\|5012239_5013691_-\|beta-glucosidase	unknown	unknown	gnl\|CDD\|274539
NZ_CP053564.1\|WP_172169042.1\|5009884_5010232_+\|metal-sulfur-cluster-assembly-factor	unknown	unknown	gnl\|CDD\|225062
NZ_CP053564.1\|WP_172162327.1\|5001353_5002277_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP053564.1\|WP_172162342.1\|5015545_5016868_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270303
NZ_CP053564.1\|WP_172169057.1\|5022139_5023846_-\|NAD(P)H-dependent-oxidoreductase-subunit-E	unknown	unknown	gnl\|CDD\|224806
NZ_CP053564.1\|WP_172162338.1\|5009402_5009846_+\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	unknown	unknown	gnl\|CDD\|273918

Protein	Function_ID	Function_description	E-value
NZ_CP053564.1\|WP_172162346.1\|5018120_5018942_-\|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	gnl\|CDD\|234823	PRK00724, PRK00724, formate dehydrogenase accessory sulfurtransferase FdhD.	4.22212e-118
NZ_CP053564.1\|WP_172162328.1\|5002286_5003888_-\|polyprenol-phosphomannose-dependent-alpha-1,6-mannosyltransferase-MptB	gnl\|CDD\|274589	TIGR03459, crt_membr, carotene biosynthesis associated membrane protein. This model represents a family of hydrophobic and presumed membrane proteins found in the Actinobacteria. The genes encoding these proteins are syntenically associated with (found proximal to) genes of carotene biosynthesis ususally including phytoene synthase (crtB), phytoene dehydrogenase (crtI) and geranylgeranyl pyrophosphate synthase (ispA).	7.40177e-62
NZ_CP053564.1\|WP_172169045.1\|5010280_5011198_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|366009	pfam00296, Bac_luciferase, Luciferase-like monooxygenase.	7.70873e-33
NZ_CP053564.1\|WP_172162336.1\|5008138_5009401_+\|cysteine-desulfurase	gnl\|CDD\|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_CP053564.1\|WP_172162350.1\|5023876_5026813_-\|formate-dehydrogenase-subunit-alpha	gnl\|CDD\|225918	COG3383, COG3383, Uncharacterized anaerobic dehydrogenase [General function prediction only].	0
NZ_CP053564.1\|WP_172162344.1\|5017014_5018046_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	7.25243e-96
NZ_CP053564.1\|WP_172162330.1\|5004731_5006159_+\|Fe-S-cluster-assembly-protein-SufB	gnl\|CDD\|131035	TIGR01980, UPF0051_protein_slr0074, FeS assembly protein SufB. This protein, SufB, forms a cytosolic complex SufBCD. This complex enhances the cysteine desulfurase of SufSE. The system, together with SufA, is believed to act in iron-sulfur cluster formation during oxidative stress. Note that SufC belongs to the family of ABC transporter ATP binding proteins, so this protein, encoded by an adjacent gene, has often been annotated as a transporter component. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_CP053564.1\|WP_172162332.1\|5006155_5007337_+\|Fe-S-cluster-assembly-protein-SufD	gnl\|CDD\|273908	TIGR01981, UPF0051_protein_Rv1462/MT1509, FeS assembly protein SufD. This protein, SufD, forms a cytosolic complex SufBCD. This complex enhances the cysteine desulfurase of SufSE. The system, together with SufA, is believed to act in iron-sulfur cluster formation during oxidative stress. SufB and SufD are homologous. Note that SufC belongs to the family of ABC transporter ATP binding proteins, so this protein, encoded by an adjacent gene, has often been annotated as a transporter component. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	1.5343e-73
NZ_CP053564.1\|WP_172162348.1\|5018941_5020855_-\|molybdopterin-biosynthesis-protein	gnl\|CDD\|237732	PRK14498, PRK14498, putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional.	0
NZ_CP053564.1\|WP_172169051.1\|5014571_5015534_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	5.62758e-84
NZ_CP053564.1\|WP_172169054.1\|5020890_5022108_-\|molybdopterin-molybdenumtransferase-MoeA	gnl\|CDD\|237732	PRK14498, PRK14498, putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional.	1.02451e-126
NZ_CP053564.1\|WP_172162334.1\|5007362_5008124_+\|Fe-S-cluster-assembly-ATPase-SufC	gnl\|CDD\|223473	COG0396, sufC, Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones].	2.19631e-143
NZ_CP053564.1\|WP_172169048.1\|5013687_5014428_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	3.00959e-71
NZ_CP053564.1\|WP_172169039.1\|5003886_5004735_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	2.69083e-54
NZ_CP053564.1\|WP_172162340.1\|5012239_5013691_-\|beta-glucosidase	gnl\|CDD\|274539	TIGR03356, BGL, beta-galactosidase.	0
NZ_CP053564.1\|WP_172169042.1\|5009884_5010232_+\|metal-sulfur-cluster-assembly-factor	gnl\|CDD\|225062	COG2151, PaaD, Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only].	4.6221e-33
NZ_CP053564.1\|WP_172162327.1\|5001353_5002277_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	3.95791e-84
NZ_CP053564.1\|WP_172162342.1\|5015545_5016868_-\|extracellular-solute-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.96995e-29
NZ_CP053564.1\|WP_172169057.1\|5022139_5023846_-\|NAD(P)H-dependent-oxidoreductase-subunit-E	gnl\|CDD\|224806	COG1894, NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion].	1.62398e-129
NZ_CP053564.1\|WP_172162338.1\|5009402_5009846_+\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	gnl\|CDD\|273918	TIGR01994, Iron-sulfur_cluster_assembly_scaffold_protein_IscU, SUF system FeS assembly protein, NifU family. Three iron-sulfur cluster assembly systems are known so far. ISC is broadly distributed while NIF tends to be associated with nitrogenase in nitrogen-fixing bacteria. The most recently described is SUF, believed to be important to maintain the function during aerobic stress of enzymes with labile Fe-S clusters. It is fairly widely distributed. This family represents one of two different proteins proposed to act as a scaffold on which the Fe-S cluster is built and from which it is transferred. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	2.61215e-59

>NZ_CP053564.1|WP_172169045.1|5010280_5011198_+|LLM-class-flavin-dependent-oxidoreductase
MLRREVPPEHTVAYARGVEALGFDELWLVEDCFYAGAVAAGAVALAATERIEVGLGVLPAVFRNPAATALEVAALARMFPGRLRPGLGHGVTGWMRQIGAFPSSQLAALEETTSALRALLRGERVTVDGRHVHLDDVVLEFPPPVVPPVATGVRGPRSLRVSGRVADGTVLTELSVPSYVRWARERIDEGRAEAGRTDPHHLTVYAYAAPDRAALLPLVADGLRGGGGAGQWGELADPIASWREAGGSGDLPDAWLDALTVSGDGARGSLAALVEAGADSVVLIPAAEDPDDALAELGALRSVLS
>NZ_CP053564.1|WP_172169042.1|5009884_5010232_+|metal-sulfur-cluster-assembly-factor
MPEPPAPAAGPSIDDLEEAMRDVVDPELGINVVDLGLVYGIQAVDGVATIDMTLTSAACPLTDVIEEQTRSALTGGGQGGLVDDIKINWVWMPPWGPDKITEDGREQLRALGFRV
>NZ_CP053564.1|WP_172162338.1|5009402_5009846_+|SUF-system-NifU-family-Fe-S-cluster-assembly-protein
MQLEQMYQEIILDHYRTPHGAGLREPFDAESFQINPTCGDEITLRVKLDGDTVAEVSHDTLGCSISQASASVLTDLVVGRSVGDSMKILQAFQEMTQGRGKVEPDEDVLGDGVAFAGVAKYPARVKCALLGWMAFKDAVVRTEGEKA
>NZ_CP053564.1|WP_172162336.1|5008138_5009401_+|cysteine-desulfurase
MDVTKIRADFPILARTVRGGRPLVYLDSGATAQRPRQVLDAERSFLEQHNAAVHRGAHQLAEEATDAYESARARIAAFVGADPGEVVFVKNATEGINLVAYAMGNAAGFPGAERFEIGPGDEIVVTDLEHHANLVPWQELCRRTGAVLKWFQVGDDGRLDLGSGSDGGDPITERTKIVAFAHQSNVLGTILPVAELSRRARAVGALVLLDACQSVPHMPVNLTELDVDFAVFSGHKMLGPSGVGVLYGRAELLAAMPPFLTGGSMIEMVRMEGSTYAPPPQRFEAGVPMTSQAVGLAAAVDYLTEIGMDAVHAHEQELTALAIEGLSSVPGVRVIGPATTDDRGGAVAFVVDGVHAHDVGQVLDDRGVAIRVGHHCAWPLHRRFGVAATARASFHVYNTPEEVTALVDGVRAAREFFGVA
>NZ_CP053564.1|WP_172162334.1|5007362_5008124_+|Fe-S-cluster-assembly-ATPase-SufC
MSTLEIKDLHVSIAVDGGTKEILTGVDLTINAGETHAIMGPNGSGKSTLAYAIAGHPKYEVTSGEILLDGADVLAMTVDERARAGLFLAMQYPVEVPGVSTANFLRSAATAVRGEAPKLRTWVKEVKTAMADLEIDAAFAERNVNEGFSGGEKKRQEVLQLSLLKPKFAVLDETDSGLDVDALRVVSAGVNRYREGGETGVLLITHYTRILQHIHPDVVHVFAGGKVVESGGPELADELEKNGYVRFTQPASV
>NZ_CP053564.1|WP_172162332.1|5006155_5007337_+|Fe-S-cluster-assembly-protein-SufD
MSEGRMTETIAGLAPELAGAKKGMGSKPLASASERFTSYDVAAFEVPSGREENWRFTPKRRLRGLWETTEFSAAPEVVVSDGASVETVGRDDARIGEGGIPADRIAAAAWSGFDRATVVTLDGTPEPVTVTVTGPGEGVVAAGHVQIRTTPHTVATVVVVNRGSGTLADNLEVVVADGSTLHLVVTEEWADDAVHAGAHHFSVGRDATLRAVAVQLGGDLVRIVSTVNYRGPGGDAELLGLGYADAEQHLEQRLLVDHGVSHCRSNVLYKNALQGTGAHTVWIGDVLIRAAAESTETFEFNRNLVLTPGARADSVPNLEIETGEIVSAGHASATGRFDDEQLFYLQSRGIPEDAARRLVVRGFFGEILSKITLPDLRERLEALVEAELAVTGV
>NZ_CP053564.1|WP_172162330.1|5004731_5006159_+|Fe-S-cluster-assembly-protein-SufB
MTTAPEALTQEETLATLGRYDFGWADPDAAGATARRGLSADVVADISALKSEPQWMLDFRLKALDMFEKKPMPRWGSDLSGIDFDNIKYFVRSSEKQAATWDDLPADIKNTYDKLGIPEAEKARLVSGVAAQYESEVVYHSIREDLEEQGVIFLDTDTALKEHPEMFREYFGSVIPSGDNKFSALNSAVWSGGSFIYVPPGVHVDIPLQAYFRINTENMGQFERTLIIVDEGAYVHYVEGCTAPIYSSDSLHSAVVEIIVKKGGRCRYTTIQNWSNNVYNLVTKRAKAEAGATMEWVDGNLGSKVTMKYPAVMLMGEYAKGEVLSIAFAGEGQHQDAGAKMTHLAPHTSSTIISKSVARGGGRTSYRGLVRVNPNAHHSRSTVKCDALLVDTISRSDTYPYVDVRNDDVSMGHEATVSKVSEDQLFYLMSRGLTEDEAMAMVVRGFVEPIARELPMEYALELNRLIELQMEGSVG
>NZ_CP053564.1|WP_172169039.1|5003886_5004735_+|winged-helix-turn-helix-transcriptional-regulator
MAGAYRGGPGVKRLTRGGGAFAVSGHIRNTGVVKSTGTPLDGHLPADGRTRESVARLLMEQGPIVAADVAARLGLSSPAVRRHLDALIADGEAEVRDAPRRGPRGRGRPAREYLLTDSGRARFGHGYDDLAVAALRYLVEHGGPDAVEGFAQSRVEQLLGDGVAKVEAAHGSGARVQALADVLTARGYAAQARDGGHGVQLCQHHCPVAHVAAEFPALCEAETHAFAELLGTHVQRLATIARGDSACTTHIPLDLPEVRRMNTTTTPGPRPGATIPRGRQSE
>NZ_CP053564.1|WP_172162328.1|5002286_5003888_-|polyprenol-phosphomannose-dependent-alpha-1,6-mannosyltransferase-MptB
MTAPGVDTTTAPGGPPPAPARDPSRTARLFGLVGSLLMAGGALGSGALPVPNPLFGIRVLSLPSRNATVAIAVTYAGIGMVVLAWLWIGKMLRANGAVAPAPDRTQLARTAVLWAIPLALAPPLFSRDVYSYLAQSATLARGLDPYTLGPAEAFGVDDPLVRSIPTIWRDTGAPYGPFFLVLGRGITALTGNDIVAGVFAHRALALLGVAMIVWVLPKLARRCGLDVGLAMWLGAANPLVLFHLVSGMHNESLMVGLMLVGFEVGLRAGDRWWDPHLLAGGVLIVLASAVKLPALLALGFLGIEWARRRGGRVRDVAVATALYTGIAVLVYAAFGIGTGLGLAWLDALDAPSLIRSWLSISTDFGLLGGQVGIILGGLGDHTDAVLGLTRTAGLVLAALLAGWLMLAVLRGRLDAITGMAAGMAAVVVLSPIVHPWYLLWAVIPLAATKAMPKARRAMLIISGILAIVVPPTGADFNFRAYQLPMSIVAGLLVIALTLLVVRRSLVGRTGVDVDAWPGHVPAGRPKEDRGAPL
>NZ_CP053564.1|WP_172162327.1|5001353_5002277_-|ABC-transporter-ATP-binding-protein
MSSQPAVSVRGLVKRYGRSTAVDGLDLELAPSSVLALLGPNGAGKTTTVEVCTGFARADAGEVRVLGVDPAGAPDALRARIGVMPQGGGAYPGVHAGEMLRVVAACAAHPLDVGWLSGVLGLDACGRTPYKRLSGGQQQRLALACAVVGRPELVFLDEPTAGMDPQGRRLVWDLISALRRDGVAVLLTTHLMEEAEALADDVVIVDHGRVVAHGTPAALTAGEQQELRFRARPGMDLAGLRTALPDGYGAAEPIAGRYLVQGRINPTVLSVITSWCAEQGALADDVQVARRSLEDVFLELTGRELRA
>NZ_CP053564.1|WP_172162340.1|5012239_5013691_-|beta-glucosidase
MTGVTTTQAQPTTLPLTFPPGFLWGSATAAYQIEGAVAEGGRTPSIWDTYAHTPGRIAGGDTGDVADDHYHRFRDDVALMKRLGLTSYRFSVSWSRITPQVTADGLGPVNAEGVAFYSGLVDALLAAGITPAVTLYHWDLPQALEDAGGWASRSTAERFGEYAGVVAAALGDRVRLFITLNEPWCTAYLGYASGVHAPGRTEDAAALAAVHHLNLAHGLGAAAVRRAVPDARVSISLNLVWVRPETPSARDVDAARRVDGLQNRVFLDPLLHGTYPSDVLVDTASVTDWGFVRPGDLDVIAAGGVDVLGVNYYSPTVVRHWTRERPKEYADGHGDGAASPWIACEDVEFPRRPGRKTDMGWGIDPRGMTELLVRMAREHPGLELMVTENGAAFPDVVGADGRVADPDRREYLRTHIAAVHAAIAAGAPVIGYCVWSLLDNFEWAWGYGKRFGIVHVDYDTQERTVKDSALFYADVIRANAVQP
>NZ_CP053564.1|WP_172169048.1|5013687_5014428_-|carbohydrate-ABC-transporter-permease
MIVAASRPMAEMNQTPPPLLPGPDLWSNIVKAVESQDIGLALMNSMIVSGVITVSTVLLCTLAGFAFAKMRFRGRNVLFGIALGTMMIPPSLGVVPLYALMATLGLAGDLSSVILPSLVQCFGVFFMRQYLIQTLPDELLDAAKVDGATSLRTFWSIVLPIARPGMAVLAMLTFMTAWNDFFWPVITLNSSNPTVQVALNNLGSGYVPDTSVIMAGTLVGTLPVIVVFLLLGRQIVGGIIAGAVKG
>NZ_CP053564.1|WP_172169051.1|5014571_5015534_-|sugar-ABC-transporter-permease
MSTPARPVPGERTPPPGSGTPRRSWRTRLFQAEERTAPYVYVAPFFLLFAAFGLFPLVQTAWISLHSYKLGSEMKWLGLENYVWLFSNPDFYNSLWKTFTIGVLSTVPQLMIALGLAHLLNYRMRGRTFFRVAMIMPYATSVAAAALVFAQLFGRDAGAVNWLLGVVGVDAVDWRNGDWTAQLAISIIVIWRWTGYNALIYLAGMQSISQDLYEAAALDGASRWQQFRHVTLPGLRPTILFTAVVSTIGASQLFGEPLIFGGGQPDGGALGQYQTLGLFMYQQGWTYGSLGRAATVAWVTFLLIIVLVLVNTAITRRRQP
>NZ_CP053564.1|WP_172162342.1|5015545_5016868_-|extracellular-solute-binding-protein
MTTTPRTTPRTTRVRTARTTLAAAVAGTLLLAACGGGGGAAADDGTTELTVSLFGTFGYEELGLFDRYEAEHPGVTITYESTQGEDKYWPALQTRLASGSGVADIQGIEVARIADVVANQAELWTDLRNTPAAGSIGNYVEWKEPAATTPDGAVLGLGTDIGPMGICYRSDLLAQAGLPTEPAALSARMTSWEDYVALGREYQAAAPAGSAWMDSAGGFYNAIVSTEQTIYYDQAGTLVHDSNPAVRAAFDTAAAAGQAGLTARLEQFVDPGWDAGFASGSFATIACPSWMIGYIKGKAGDAGSGLWNVTTLPGGAGGNWGGAYLGIPASSENVEEAAELIAWLTAPERQAEVFASAGNFPSTTGGIEMVADATDPWFNGAPIGQIFSTSTANAPVQILGPEDGVIKSAMVEALLSVEANGVAPADAWNSALSTVSNQVS
>NZ_CP053564.1|WP_172162344.1|5017014_5018046_-|LacI-family-DNA-binding-transcriptional-regulator
MSGRDGRGAPTLESVAALAGVSRATAGRVLSGSTKVGPRARDAVLAAAAELHYVTNRAARSLMTRRSDSIAFVVAESEDRFFADPYFSQVLHGAHGVVARHDMQLVFAVVSGDDTERQRFERFALGGHLDGAILVSLHGDDPLPRRLQDAGVPVVLSGRPFAHQARTPLTYVDADNVGGAMAAVRLLAQQGRRRIATITGPLDMAASVDRVDGFRAELAAHDVVDAGSADGDFSIVGGRRAMADLLAADPLIDAVFAANDLMAVGALQAVREAGRRVPEDVAVVGFDDSAIAVSAQPPLTTVRQPMVEMGRTLATLLLDQITHGGEPQAPVILPTEIVRRASA
>NZ_CP053564.1|WP_172162346.1|5018120_5018942_-|formate-dehydrogenase-accessory-sulfurtransferase-FdhD
MGRLSVRRPVVRIGPDGRRRTLDTLAAEEPLELRVDGKPLSVTMRTPGHDVELAHGFLLTEGVLGSASDVLTARYCDSFDDDGRNTYNVLDIALAAGVEPPDASLERNFYTTSSCGVCGKASLDAVRLKTRFSPAADPLVVTPAVLSALPDALRGAQKLFDSTGGLHGAGLFTADGELLVAREDVGRHNAVDKVLGWALLQDRVPAAGTVLMVSGRASFELVQKAVMAGVPLLSAVSAPSSLAVELAQDAGVTLVGFLRGETMNVYSHDARVT
>NZ_CP053564.1|WP_172162348.1|5018941_5020855_-|molybdopterin-biosynthesis-protein
MTRSGPFVSDVPTAEATAAWRAACAAAGCPERTGTEHVPVAGAVGRVLAEPVWAVRSSPAFDSAAMDGIAVRAAETVGAADTTPVLLADFAVVDTGDPMPVGYDAVVMREHVHHTADGRAELRAAVPPYEHVRSIGEDISATELLLPAGHRMRPVDVAAAAAAGAVAPAVHRRPHVVVIPTGDEIRPVGTEPGPGEILDTNSIMLVAQAREAGCTAAATEIVPDDPERITAALRAAAAGADLVVLIAGSSAGRDDHTAGVVAGAGTLAVHGVAVRPGHPVVLGVVEGGTPVLGAPGYPVSAALTFEIFALPLLAALEGAAPRERPSTTARLARKLASVIGSDDWVRVRLGRVGGEVVATPLPRGAGVLTSLVRADGLLVVPAGVEGHHAGERVRVELLRGLAEIARTIVAIGSHDLVLDMAASALRSADPLLTLASSNVGSLGGLVALRDGLCHLAGSHLLDPATGAYTLPYVDRLLGDLDVAVVRLVHRDQGLIVAPGNPLGLTGIDDLVRPGLRYVNRQRGAGTRALLDHELGARGVDPSAVPGYAREEHTHLAVAAAVAAGRADAGMGILAAARAFGLDFVPVAQEPYDLVVRADALDDPLLAPLWALLDDPAFRGGIEALGGYSCAETGRRVR
>NZ_CP053564.1|WP_172169054.1|5020890_5022108_-|molybdopterin-molybdenumtransferase-MoeA
MSGREFFTARTVAEALAGFTPARRTAVETVAAADARHRVPAEPVRAAAALPGFAKSTVDGFAVRAADTYGASEGLPSYLDLAGAVRMGRAPTVAVPPGGAVAIPTGGVLPEGADAVVMVEHTAETMPGTIEVTRPVAPGAGLVRADEDVAAGGVLVRAGRPLRAPDLGLLAAAGVTEIAVHARPRVVILSTGDEVVPPSTREPAPGQVRDATASALAALVADAGGVPELAGIVGDEPGALTAALRGVLPRADLVVVSAGSSVGTRDETAGAIAALGEVWCHGLAIRPGKPTLLAECGGVPVVGLPGNPLSALVVFGLVGVPLVWRLAGAGAPPQPATRARLARDVASAAGRLDVVQVELRDGEAHPVFGPSALLSVLTRADGYVVVPEPATGLAAGTEVIVTLHR
>NZ_CP053564.1|WP_172169057.1|5022139_5023846_-|NAD(P)H-dependent-oxidoreductase-subunit-E
MRARRVPGVEARAGKFPGPSLIPALNAIQARLGWLPREELEELAREARRPRYEIEGLVSFYPHFRTSPPPAVALHACHDLPCFLRGGEERIAELRERFGEGGRDNPGDVELVEVSCLGRCDVAPAVAVNERPAALSDVDDLVAAARAGGVGDAPARERDEPWPNDPYPAGTGVAQRYATLRALRDGEVDAATVIATLKDSGLRGMGGAGFPTGQKWDLVRGAQPGSTKYVICNADESEPGTFKDRQILATQPHLVLEGLLVAMEVVDAQEGWVFIRHEYGPEEHVLRAEIDALRAAGLVGPGRQVDVFVSPGGYILGEETALLECMEGHRGEPRNKPPFPGNYGLHGRPTLINSVETFADVPVIVQRGAQWWADQGLGDSVGWKFFAVSGHVERPDVYCVPMGTTVGALIELAGGVSEGRALGAVQPGGASSNFIGPERLGTALDFGSAAEAGTMLGSGALVVLAEGSDLLAASTNVLRFFRNESCGKCVPCRVGSTKAHELLAGRSELDDDERAQILRLEEAMRKTSICGLGQVALGPVVSVLGLDKGGAAARDHPKPGGEPAQPDR
>NZ_CP053564.1|WP_172162350.1|5023876_5026813_-|formate-dehydrogenase-subunit-alpha
MTTLQEPPAPTSAPTVTATIDGREVTVAEGTTIYDAARRAGVDIPVLCHDERYDPVGVCRMCVVDTGGRVFAAACVRPCEDGMEVVTTSEELDRSRAVLTELLVADQPPIAEDPKQTTTGDNLLLALEQGLGVERGALPCGSGRGHDSSNPVIDVDHDACILCDRCVRACDDIQGNDVIGRTGKGYATRIAFDLDDPMGASSCVTCGECVQACPTGALTNKSIRDIAIRPREELDAVESVCPYCGVGCAITYRVDREQNAISFAEGRDQPGSQSRLCVKGRYGWDYAASPQRLTVPLIRVDAAYPKGALSADVRGEGTGDRATGRGGGDNDRGRGGGGGDRSRKPGDKRGGHRKPGGLVDYDEVLPHFREATWEEALDLVARRLREIHAEGGPESIAGFGSAKCSNEEAYLFQKLIRTGFGTNNVDHCTRLCHASSVAALFEGVGSGAVSTTYGDVVNADVVIITGSNPTANHPVASSFFKQARRRGTKIIYVDPRASTVAEHADIHIQLKPGTDVAFYNAVMHEVIRLGLIDREFIASRTSNYDELARTVADYPPDRAAQITGVDADSIREVARTWGEAGAGVVYWGMGISQHTTGTDNARCLIALCSITGNVGRPGTGLHPLRGQNNVQGASDAGLIPMFYPDYQGVDREATQARFEEAWGTPLNPQRGLTVTEIISSALQPDGGVRGMYMLGENPFLSDPNINKVRKALSALDFLVVQDIFLTETAEFADVILPATSYLEKDGTYTNTDRRVQLGRKVLDAPGQARPDWEIVQDIAQRVGLDWAYGSPSEVFDEMVALMPSYANLAHGNLGSSGKLYPNSDPEHTDGTVVMFVERFNTDDGLAHLVPAQWLPPKELPDGEYPLVLNTGRLLEHWHTGSMTRRSYALDAISPVAEVYMHPKDAAERGMAHGQRVRARSRRGEIELQVRISHREQLGNVFIPFHFREAAANLLTIDEVDPFGKIPEFKFCAVQVEVL

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Crispr_ID: NZ_CP053564_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053564_5

5011249-5011502

Orphan

Consensus_repeat	Method
CCGGGTGGTCGTGCGTTCCGCGGAAC	CRISPRCasFinder

4 spacers

The CRISPR arrays of NZ_CP053564_5

>merge|NZ_CP053564|5|5011249-5011502|CRISPRCasFinder
CTGAGCGCTCTCGTGTTCCGCGGAACGCGGCTTGCCGCGTTCGGTTCCGCCGGTGCTGCCGGGTGGTCGTGCGTTCCGCGGAACGCTCCTCGGCGGGGCCGGTACCCGGCGCGACCGGGCGGTCGTGCGTTCCGCGGAACTCTGCTCGCCGGGGCTGGTACCCGGCGCTGCCTGGCGTTCCTGCGTTCCGCGGAACGCGCGGTTCGCGGGGTTCGAGTTACCGCGCGCCGGGCGCTCGTGCGCTCCGCGGAACG

>NZ_CP053564|5|3|5011249-5011502|CRISPRCasFinder
CTGAGCGCTCTCGTGTTCCGCGGAAC	GCGGCTTGCCGCGTTCGGTTCCGCCGGTGCTG
CCGGGTGGTCGTGCGTTCCGCGGAAC	GCTCCTCGGCGGGGCCGGTACCCGGCGCGA
CCGGGCGGTCGTGCGTTCCGCGGAAC	TCTGCTCGCCGGGGCTGGTACCCGGCGCTG
CCTGGCGTTCCTGCGTTCCGCGGAAC	GCGCGGTTCGCGGGGTTCGAGTTACCGCGCG
CCGGGCGCTCGTGCGCTCCGCGGAACG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053564.1\|WP_172162346.1\|5018120_5018942_-\|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	unknown	unknown	gnl\|CDD\|234823
NZ_CP053564.1\|WP_172162328.1\|5002286_5003888_-\|polyprenol-phosphomannose-dependent-alpha-1,6-mannosyltransferase-MptB	unknown	unknown	gnl\|CDD\|274589
NZ_CP053564.1\|WP_172169045.1\|5010280_5011198_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366009
NZ_CP053564.1\|WP_172162336.1\|5008138_5009401_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|131034
NZ_CP053564.1\|WP_172162350.1\|5023876_5026813_-\|formate-dehydrogenase-subunit-alpha	unknown	unknown	gnl\|CDD\|225918
NZ_CP053564.1\|WP_172162344.1\|5017014_5018046_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP053564.1\|WP_172162330.1\|5004731_5006159_+\|Fe-S-cluster-assembly-protein-SufB	unknown	unknown	gnl\|CDD\|131035
NZ_CP053564.1\|WP_172162332.1\|5006155_5007337_+\|Fe-S-cluster-assembly-protein-SufD	unknown	unknown	gnl\|CDD\|273908
NZ_CP053564.1\|WP_172162348.1\|5018941_5020855_-\|molybdopterin-biosynthesis-protein	unknown	unknown	gnl\|CDD\|237732
NZ_CP053564.1\|WP_172169051.1\|5014571_5015534_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP053564.1\|WP_172169054.1\|5020890_5022108_-\|molybdopterin-molybdenumtransferase-MoeA	unknown	unknown	gnl\|CDD\|237732
NZ_CP053564.1\|WP_172162334.1\|5007362_5008124_+\|Fe-S-cluster-assembly-ATPase-SufC	unknown	unknown	gnl\|CDD\|223473
NZ_CP053564.1\|WP_172169048.1\|5013687_5014428_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP053564.1\|WP_172169039.1\|5003886_5004735_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225222
NZ_CP053564.1\|WP_172162340.1\|5012239_5013691_-\|beta-glucosidase	unknown	unknown	gnl\|CDD\|274539
NZ_CP053564.1\|WP_172169042.1\|5009884_5010232_+\|metal-sulfur-cluster-assembly-factor	unknown	unknown	gnl\|CDD\|225062
NZ_CP053564.1\|WP_172162327.1\|5001353_5002277_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP053564.1\|WP_172162342.1\|5015545_5016868_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270303
NZ_CP053564.1\|WP_172169057.1\|5022139_5023846_-\|NAD(P)H-dependent-oxidoreductase-subunit-E	unknown	unknown	gnl\|CDD\|224806
NZ_CP053564.1\|WP_172162338.1\|5009402_5009846_+\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	unknown	unknown	gnl\|CDD\|273918

Protein	Function_ID	Function_description	E-value
NZ_CP053564.1\|WP_172162346.1\|5018120_5018942_-\|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	gnl\|CDD\|234823	PRK00724, PRK00724, formate dehydrogenase accessory sulfurtransferase FdhD.	4.22212e-118
NZ_CP053564.1\|WP_172162328.1\|5002286_5003888_-\|polyprenol-phosphomannose-dependent-alpha-1,6-mannosyltransferase-MptB	gnl\|CDD\|274589	TIGR03459, crt_membr, carotene biosynthesis associated membrane protein. This model represents a family of hydrophobic and presumed membrane proteins found in the Actinobacteria. The genes encoding these proteins are syntenically associated with (found proximal to) genes of carotene biosynthesis ususally including phytoene synthase (crtB), phytoene dehydrogenase (crtI) and geranylgeranyl pyrophosphate synthase (ispA).	7.40177e-62
NZ_CP053564.1\|WP_172169045.1\|5010280_5011198_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|366009	pfam00296, Bac_luciferase, Luciferase-like monooxygenase.	7.70873e-33
NZ_CP053564.1\|WP_172162336.1\|5008138_5009401_+\|cysteine-desulfurase	gnl\|CDD\|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_CP053564.1\|WP_172162350.1\|5023876_5026813_-\|formate-dehydrogenase-subunit-alpha	gnl\|CDD\|225918	COG3383, COG3383, Uncharacterized anaerobic dehydrogenase [General function prediction only].	0
NZ_CP053564.1\|WP_172162344.1\|5017014_5018046_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	7.25243e-96
NZ_CP053564.1\|WP_172162330.1\|5004731_5006159_+\|Fe-S-cluster-assembly-protein-SufB	gnl\|CDD\|131035	TIGR01980, UPF0051_protein_slr0074, FeS assembly protein SufB. This protein, SufB, forms a cytosolic complex SufBCD. This complex enhances the cysteine desulfurase of SufSE. The system, together with SufA, is believed to act in iron-sulfur cluster formation during oxidative stress. Note that SufC belongs to the family of ABC transporter ATP binding proteins, so this protein, encoded by an adjacent gene, has often been annotated as a transporter component. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_CP053564.1\|WP_172162332.1\|5006155_5007337_+\|Fe-S-cluster-assembly-protein-SufD	gnl\|CDD\|273908	TIGR01981, UPF0051_protein_Rv1462/MT1509, FeS assembly protein SufD. This protein, SufD, forms a cytosolic complex SufBCD. This complex enhances the cysteine desulfurase of SufSE. The system, together with SufA, is believed to act in iron-sulfur cluster formation during oxidative stress. SufB and SufD are homologous. Note that SufC belongs to the family of ABC transporter ATP binding proteins, so this protein, encoded by an adjacent gene, has often been annotated as a transporter component. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	1.5343e-73
NZ_CP053564.1\|WP_172162348.1\|5018941_5020855_-\|molybdopterin-biosynthesis-protein	gnl\|CDD\|237732	PRK14498, PRK14498, putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional.	0
NZ_CP053564.1\|WP_172169051.1\|5014571_5015534_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	5.62758e-84
NZ_CP053564.1\|WP_172169054.1\|5020890_5022108_-\|molybdopterin-molybdenumtransferase-MoeA	gnl\|CDD\|237732	PRK14498, PRK14498, putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional.	1.02451e-126
NZ_CP053564.1\|WP_172162334.1\|5007362_5008124_+\|Fe-S-cluster-assembly-ATPase-SufC	gnl\|CDD\|223473	COG0396, sufC, Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones].	2.19631e-143
NZ_CP053564.1\|WP_172169048.1\|5013687_5014428_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	3.00959e-71
NZ_CP053564.1\|WP_172169039.1\|5003886_5004735_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	2.69083e-54
NZ_CP053564.1\|WP_172162340.1\|5012239_5013691_-\|beta-glucosidase	gnl\|CDD\|274539	TIGR03356, BGL, beta-galactosidase.	0
NZ_CP053564.1\|WP_172169042.1\|5009884_5010232_+\|metal-sulfur-cluster-assembly-factor	gnl\|CDD\|225062	COG2151, PaaD, Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only].	4.6221e-33
NZ_CP053564.1\|WP_172162327.1\|5001353_5002277_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	3.95791e-84
NZ_CP053564.1\|WP_172162342.1\|5015545_5016868_-\|extracellular-solute-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.96995e-29
NZ_CP053564.1\|WP_172169057.1\|5022139_5023846_-\|NAD(P)H-dependent-oxidoreductase-subunit-E	gnl\|CDD\|224806	COG1894, NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion].	1.62398e-129
NZ_CP053564.1\|WP_172162338.1\|5009402_5009846_+\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	gnl\|CDD\|273918	TIGR01994, Iron-sulfur_cluster_assembly_scaffold_protein_IscU, SUF system FeS assembly protein, NifU family. Three iron-sulfur cluster assembly systems are known so far. ISC is broadly distributed while NIF tends to be associated with nitrogenase in nitrogen-fixing bacteria. The most recently described is SUF, believed to be important to maintain the function during aerobic stress of enzymes with labile Fe-S clusters. It is fairly widely distributed. This family represents one of two different proteins proposed to act as a scaffold on which the Fe-S cluster is built and from which it is transferred. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	2.61215e-59

>NZ_CP053564.1|WP_172169045.1|5010280_5011198_+|LLM-class-flavin-dependent-oxidoreductase
MLRREVPPEHTVAYARGVEALGFDELWLVEDCFYAGAVAAGAVALAATERIEVGLGVLPAVFRNPAATALEVAALARMFPGRLRPGLGHGVTGWMRQIGAFPSSQLAALEETTSALRALLRGERVTVDGRHVHLDDVVLEFPPPVVPPVATGVRGPRSLRVSGRVADGTVLTELSVPSYVRWARERIDEGRAEAGRTDPHHLTVYAYAAPDRAALLPLVADGLRGGGGAGQWGELADPIASWREAGGSGDLPDAWLDALTVSGDGARGSLAALVEAGADSVVLIPAAEDPDDALAELGALRSVLS
>NZ_CP053564.1|WP_172169042.1|5009884_5010232_+|metal-sulfur-cluster-assembly-factor
MPEPPAPAAGPSIDDLEEAMRDVVDPELGINVVDLGLVYGIQAVDGVATIDMTLTSAACPLTDVIEEQTRSALTGGGQGGLVDDIKINWVWMPPWGPDKITEDGREQLRALGFRV
>NZ_CP053564.1|WP_172162338.1|5009402_5009846_+|SUF-system-NifU-family-Fe-S-cluster-assembly-protein
MQLEQMYQEIILDHYRTPHGAGLREPFDAESFQINPTCGDEITLRVKLDGDTVAEVSHDTLGCSISQASASVLTDLVVGRSVGDSMKILQAFQEMTQGRGKVEPDEDVLGDGVAFAGVAKYPARVKCALLGWMAFKDAVVRTEGEKA
>NZ_CP053564.1|WP_172162336.1|5008138_5009401_+|cysteine-desulfurase
MDVTKIRADFPILARTVRGGRPLVYLDSGATAQRPRQVLDAERSFLEQHNAAVHRGAHQLAEEATDAYESARARIAAFVGADPGEVVFVKNATEGINLVAYAMGNAAGFPGAERFEIGPGDEIVVTDLEHHANLVPWQELCRRTGAVLKWFQVGDDGRLDLGSGSDGGDPITERTKIVAFAHQSNVLGTILPVAELSRRARAVGALVLLDACQSVPHMPVNLTELDVDFAVFSGHKMLGPSGVGVLYGRAELLAAMPPFLTGGSMIEMVRMEGSTYAPPPQRFEAGVPMTSQAVGLAAAVDYLTEIGMDAVHAHEQELTALAIEGLSSVPGVRVIGPATTDDRGGAVAFVVDGVHAHDVGQVLDDRGVAIRVGHHCAWPLHRRFGVAATARASFHVYNTPEEVTALVDGVRAAREFFGVA
>NZ_CP053564.1|WP_172162334.1|5007362_5008124_+|Fe-S-cluster-assembly-ATPase-SufC
MSTLEIKDLHVSIAVDGGTKEILTGVDLTINAGETHAIMGPNGSGKSTLAYAIAGHPKYEVTSGEILLDGADVLAMTVDERARAGLFLAMQYPVEVPGVSTANFLRSAATAVRGEAPKLRTWVKEVKTAMADLEIDAAFAERNVNEGFSGGEKKRQEVLQLSLLKPKFAVLDETDSGLDVDALRVVSAGVNRYREGGETGVLLITHYTRILQHIHPDVVHVFAGGKVVESGGPELADELEKNGYVRFTQPASV
>NZ_CP053564.1|WP_172162332.1|5006155_5007337_+|Fe-S-cluster-assembly-protein-SufD
MSEGRMTETIAGLAPELAGAKKGMGSKPLASASERFTSYDVAAFEVPSGREENWRFTPKRRLRGLWETTEFSAAPEVVVSDGASVETVGRDDARIGEGGIPADRIAAAAWSGFDRATVVTLDGTPEPVTVTVTGPGEGVVAAGHVQIRTTPHTVATVVVVNRGSGTLADNLEVVVADGSTLHLVVTEEWADDAVHAGAHHFSVGRDATLRAVAVQLGGDLVRIVSTVNYRGPGGDAELLGLGYADAEQHLEQRLLVDHGVSHCRSNVLYKNALQGTGAHTVWIGDVLIRAAAESTETFEFNRNLVLTPGARADSVPNLEIETGEIVSAGHASATGRFDDEQLFYLQSRGIPEDAARRLVVRGFFGEILSKITLPDLRERLEALVEAELAVTGV
>NZ_CP053564.1|WP_172162330.1|5004731_5006159_+|Fe-S-cluster-assembly-protein-SufB
MTTAPEALTQEETLATLGRYDFGWADPDAAGATARRGLSADVVADISALKSEPQWMLDFRLKALDMFEKKPMPRWGSDLSGIDFDNIKYFVRSSEKQAATWDDLPADIKNTYDKLGIPEAEKARLVSGVAAQYESEVVYHSIREDLEEQGVIFLDTDTALKEHPEMFREYFGSVIPSGDNKFSALNSAVWSGGSFIYVPPGVHVDIPLQAYFRINTENMGQFERTLIIVDEGAYVHYVEGCTAPIYSSDSLHSAVVEIIVKKGGRCRYTTIQNWSNNVYNLVTKRAKAEAGATMEWVDGNLGSKVTMKYPAVMLMGEYAKGEVLSIAFAGEGQHQDAGAKMTHLAPHTSSTIISKSVARGGGRTSYRGLVRVNPNAHHSRSTVKCDALLVDTISRSDTYPYVDVRNDDVSMGHEATVSKVSEDQLFYLMSRGLTEDEAMAMVVRGFVEPIARELPMEYALELNRLIELQMEGSVG
>NZ_CP053564.1|WP_172169039.1|5003886_5004735_+|winged-helix-turn-helix-transcriptional-regulator
MAGAYRGGPGVKRLTRGGGAFAVSGHIRNTGVVKSTGTPLDGHLPADGRTRESVARLLMEQGPIVAADVAARLGLSSPAVRRHLDALIADGEAEVRDAPRRGPRGRGRPAREYLLTDSGRARFGHGYDDLAVAALRYLVEHGGPDAVEGFAQSRVEQLLGDGVAKVEAAHGSGARVQALADVLTARGYAAQARDGGHGVQLCQHHCPVAHVAAEFPALCEAETHAFAELLGTHVQRLATIARGDSACTTHIPLDLPEVRRMNTTTTPGPRPGATIPRGRQSE
>NZ_CP053564.1|WP_172162328.1|5002286_5003888_-|polyprenol-phosphomannose-dependent-alpha-1,6-mannosyltransferase-MptB
MTAPGVDTTTAPGGPPPAPARDPSRTARLFGLVGSLLMAGGALGSGALPVPNPLFGIRVLSLPSRNATVAIAVTYAGIGMVVLAWLWIGKMLRANGAVAPAPDRTQLARTAVLWAIPLALAPPLFSRDVYSYLAQSATLARGLDPYTLGPAEAFGVDDPLVRSIPTIWRDTGAPYGPFFLVLGRGITALTGNDIVAGVFAHRALALLGVAMIVWVLPKLARRCGLDVGLAMWLGAANPLVLFHLVSGMHNESLMVGLMLVGFEVGLRAGDRWWDPHLLAGGVLIVLASAVKLPALLALGFLGIEWARRRGGRVRDVAVATALYTGIAVLVYAAFGIGTGLGLAWLDALDAPSLIRSWLSISTDFGLLGGQVGIILGGLGDHTDAVLGLTRTAGLVLAALLAGWLMLAVLRGRLDAITGMAAGMAAVVVLSPIVHPWYLLWAVIPLAATKAMPKARRAMLIISGILAIVVPPTGADFNFRAYQLPMSIVAGLLVIALTLLVVRRSLVGRTGVDVDAWPGHVPAGRPKEDRGAPL
>NZ_CP053564.1|WP_172162327.1|5001353_5002277_-|ABC-transporter-ATP-binding-protein
MSSQPAVSVRGLVKRYGRSTAVDGLDLELAPSSVLALLGPNGAGKTTTVEVCTGFARADAGEVRVLGVDPAGAPDALRARIGVMPQGGGAYPGVHAGEMLRVVAACAAHPLDVGWLSGVLGLDACGRTPYKRLSGGQQQRLALACAVVGRPELVFLDEPTAGMDPQGRRLVWDLISALRRDGVAVLLTTHLMEEAEALADDVVIVDHGRVVAHGTPAALTAGEQQELRFRARPGMDLAGLRTALPDGYGAAEPIAGRYLVQGRINPTVLSVITSWCAEQGALADDVQVARRSLEDVFLELTGRELRA
>NZ_CP053564.1|WP_172162340.1|5012239_5013691_-|beta-glucosidase
MTGVTTTQAQPTTLPLTFPPGFLWGSATAAYQIEGAVAEGGRTPSIWDTYAHTPGRIAGGDTGDVADDHYHRFRDDVALMKRLGLTSYRFSVSWSRITPQVTADGLGPVNAEGVAFYSGLVDALLAAGITPAVTLYHWDLPQALEDAGGWASRSTAERFGEYAGVVAAALGDRVRLFITLNEPWCTAYLGYASGVHAPGRTEDAAALAAVHHLNLAHGLGAAAVRRAVPDARVSISLNLVWVRPETPSARDVDAARRVDGLQNRVFLDPLLHGTYPSDVLVDTASVTDWGFVRPGDLDVIAAGGVDVLGVNYYSPTVVRHWTRERPKEYADGHGDGAASPWIACEDVEFPRRPGRKTDMGWGIDPRGMTELLVRMAREHPGLELMVTENGAAFPDVVGADGRVADPDRREYLRTHIAAVHAAIAAGAPVIGYCVWSLLDNFEWAWGYGKRFGIVHVDYDTQERTVKDSALFYADVIRANAVQP
>NZ_CP053564.1|WP_172169048.1|5013687_5014428_-|carbohydrate-ABC-transporter-permease
MIVAASRPMAEMNQTPPPLLPGPDLWSNIVKAVESQDIGLALMNSMIVSGVITVSTVLLCTLAGFAFAKMRFRGRNVLFGIALGTMMIPPSLGVVPLYALMATLGLAGDLSSVILPSLVQCFGVFFMRQYLIQTLPDELLDAAKVDGATSLRTFWSIVLPIARPGMAVLAMLTFMTAWNDFFWPVITLNSSNPTVQVALNNLGSGYVPDTSVIMAGTLVGTLPVIVVFLLLGRQIVGGIIAGAVKG
>NZ_CP053564.1|WP_172169051.1|5014571_5015534_-|sugar-ABC-transporter-permease
MSTPARPVPGERTPPPGSGTPRRSWRTRLFQAEERTAPYVYVAPFFLLFAAFGLFPLVQTAWISLHSYKLGSEMKWLGLENYVWLFSNPDFYNSLWKTFTIGVLSTVPQLMIALGLAHLLNYRMRGRTFFRVAMIMPYATSVAAAALVFAQLFGRDAGAVNWLLGVVGVDAVDWRNGDWTAQLAISIIVIWRWTGYNALIYLAGMQSISQDLYEAAALDGASRWQQFRHVTLPGLRPTILFTAVVSTIGASQLFGEPLIFGGGQPDGGALGQYQTLGLFMYQQGWTYGSLGRAATVAWVTFLLIIVLVLVNTAITRRRQP
>NZ_CP053564.1|WP_172162342.1|5015545_5016868_-|extracellular-solute-binding-protein
MTTTPRTTPRTTRVRTARTTLAAAVAGTLLLAACGGGGGAAADDGTTELTVSLFGTFGYEELGLFDRYEAEHPGVTITYESTQGEDKYWPALQTRLASGSGVADIQGIEVARIADVVANQAELWTDLRNTPAAGSIGNYVEWKEPAATTPDGAVLGLGTDIGPMGICYRSDLLAQAGLPTEPAALSARMTSWEDYVALGREYQAAAPAGSAWMDSAGGFYNAIVSTEQTIYYDQAGTLVHDSNPAVRAAFDTAAAAGQAGLTARLEQFVDPGWDAGFASGSFATIACPSWMIGYIKGKAGDAGSGLWNVTTLPGGAGGNWGGAYLGIPASSENVEEAAELIAWLTAPERQAEVFASAGNFPSTTGGIEMVADATDPWFNGAPIGQIFSTSTANAPVQILGPEDGVIKSAMVEALLSVEANGVAPADAWNSALSTVSNQVS
>NZ_CP053564.1|WP_172162344.1|5017014_5018046_-|LacI-family-DNA-binding-transcriptional-regulator
MSGRDGRGAPTLESVAALAGVSRATAGRVLSGSTKVGPRARDAVLAAAAELHYVTNRAARSLMTRRSDSIAFVVAESEDRFFADPYFSQVLHGAHGVVARHDMQLVFAVVSGDDTERQRFERFALGGHLDGAILVSLHGDDPLPRRLQDAGVPVVLSGRPFAHQARTPLTYVDADNVGGAMAAVRLLAQQGRRRIATITGPLDMAASVDRVDGFRAELAAHDVVDAGSADGDFSIVGGRRAMADLLAADPLIDAVFAANDLMAVGALQAVREAGRRVPEDVAVVGFDDSAIAVSAQPPLTTVRQPMVEMGRTLATLLLDQITHGGEPQAPVILPTEIVRRASA
>NZ_CP053564.1|WP_172162346.1|5018120_5018942_-|formate-dehydrogenase-accessory-sulfurtransferase-FdhD
MGRLSVRRPVVRIGPDGRRRTLDTLAAEEPLELRVDGKPLSVTMRTPGHDVELAHGFLLTEGVLGSASDVLTARYCDSFDDDGRNTYNVLDIALAAGVEPPDASLERNFYTTSSCGVCGKASLDAVRLKTRFSPAADPLVVTPAVLSALPDALRGAQKLFDSTGGLHGAGLFTADGELLVAREDVGRHNAVDKVLGWALLQDRVPAAGTVLMVSGRASFELVQKAVMAGVPLLSAVSAPSSLAVELAQDAGVTLVGFLRGETMNVYSHDARVT
>NZ_CP053564.1|WP_172162348.1|5018941_5020855_-|molybdopterin-biosynthesis-protein
MTRSGPFVSDVPTAEATAAWRAACAAAGCPERTGTEHVPVAGAVGRVLAEPVWAVRSSPAFDSAAMDGIAVRAAETVGAADTTPVLLADFAVVDTGDPMPVGYDAVVMREHVHHTADGRAELRAAVPPYEHVRSIGEDISATELLLPAGHRMRPVDVAAAAAAGAVAPAVHRRPHVVVIPTGDEIRPVGTEPGPGEILDTNSIMLVAQAREAGCTAAATEIVPDDPERITAALRAAAAGADLVVLIAGSSAGRDDHTAGVVAGAGTLAVHGVAVRPGHPVVLGVVEGGTPVLGAPGYPVSAALTFEIFALPLLAALEGAAPRERPSTTARLARKLASVIGSDDWVRVRLGRVGGEVVATPLPRGAGVLTSLVRADGLLVVPAGVEGHHAGERVRVELLRGLAEIARTIVAIGSHDLVLDMAASALRSADPLLTLASSNVGSLGGLVALRDGLCHLAGSHLLDPATGAYTLPYVDRLLGDLDVAVVRLVHRDQGLIVAPGNPLGLTGIDDLVRPGLRYVNRQRGAGTRALLDHELGARGVDPSAVPGYAREEHTHLAVAAAVAAGRADAGMGILAAARAFGLDFVPVAQEPYDLVVRADALDDPLLAPLWALLDDPAFRGGIEALGGYSCAETGRRVR
>NZ_CP053564.1|WP_172169054.1|5020890_5022108_-|molybdopterin-molybdenumtransferase-MoeA
MSGREFFTARTVAEALAGFTPARRTAVETVAAADARHRVPAEPVRAAAALPGFAKSTVDGFAVRAADTYGASEGLPSYLDLAGAVRMGRAPTVAVPPGGAVAIPTGGVLPEGADAVVMVEHTAETMPGTIEVTRPVAPGAGLVRADEDVAAGGVLVRAGRPLRAPDLGLLAAAGVTEIAVHARPRVVILSTGDEVVPPSTREPAPGQVRDATASALAALVADAGGVPELAGIVGDEPGALTAALRGVLPRADLVVVSAGSSVGTRDETAGAIAALGEVWCHGLAIRPGKPTLLAECGGVPVVGLPGNPLSALVVFGLVGVPLVWRLAGAGAPPQPATRARLARDVASAAGRLDVVQVELRDGEAHPVFGPSALLSVLTRADGYVVVPEPATGLAAGTEVIVTLHR
>NZ_CP053564.1|WP_172169057.1|5022139_5023846_-|NAD(P)H-dependent-oxidoreductase-subunit-E
MRARRVPGVEARAGKFPGPSLIPALNAIQARLGWLPREELEELAREARRPRYEIEGLVSFYPHFRTSPPPAVALHACHDLPCFLRGGEERIAELRERFGEGGRDNPGDVELVEVSCLGRCDVAPAVAVNERPAALSDVDDLVAAARAGGVGDAPARERDEPWPNDPYPAGTGVAQRYATLRALRDGEVDAATVIATLKDSGLRGMGGAGFPTGQKWDLVRGAQPGSTKYVICNADESEPGTFKDRQILATQPHLVLEGLLVAMEVVDAQEGWVFIRHEYGPEEHVLRAEIDALRAAGLVGPGRQVDVFVSPGGYILGEETALLECMEGHRGEPRNKPPFPGNYGLHGRPTLINSVETFADVPVIVQRGAQWWADQGLGDSVGWKFFAVSGHVERPDVYCVPMGTTVGALIELAGGVSEGRALGAVQPGGASSNFIGPERLGTALDFGSAAEAGTMLGSGALVVLAEGSDLLAASTNVLRFFRNESCGKCVPCRVGSTKAHELLAGRSELDDDERAQILRLEEAMRKTSICGLGQVALGPVVSVLGLDKGGAAARDHPKPGGEPAQPDR
>NZ_CP053564.1|WP_172162350.1|5023876_5026813_-|formate-dehydrogenase-subunit-alpha
MTTLQEPPAPTSAPTVTATIDGREVTVAEGTTIYDAARRAGVDIPVLCHDERYDPVGVCRMCVVDTGGRVFAAACVRPCEDGMEVVTTSEELDRSRAVLTELLVADQPPIAEDPKQTTTGDNLLLALEQGLGVERGALPCGSGRGHDSSNPVIDVDHDACILCDRCVRACDDIQGNDVIGRTGKGYATRIAFDLDDPMGASSCVTCGECVQACPTGALTNKSIRDIAIRPREELDAVESVCPYCGVGCAITYRVDREQNAISFAEGRDQPGSQSRLCVKGRYGWDYAASPQRLTVPLIRVDAAYPKGALSADVRGEGTGDRATGRGGGDNDRGRGGGGGDRSRKPGDKRGGHRKPGGLVDYDEVLPHFREATWEEALDLVARRLREIHAEGGPESIAGFGSAKCSNEEAYLFQKLIRTGFGTNNVDHCTRLCHASSVAALFEGVGSGAVSTTYGDVVNADVVIITGSNPTANHPVASSFFKQARRRGTKIIYVDPRASTVAEHADIHIQLKPGTDVAFYNAVMHEVIRLGLIDREFIASRTSNYDELARTVADYPPDRAAQITGVDADSIREVARTWGEAGAGVVYWGMGISQHTTGTDNARCLIALCSITGNVGRPGTGLHPLRGQNNVQGASDAGLIPMFYPDYQGVDREATQARFEEAWGTPLNPQRGLTVTEIISSALQPDGGVRGMYMLGENPFLSDPNINKVRKALSALDFLVVQDIFLTETAEFADVILPATSYLEKDGTYTNTDRRVQLGRKVLDAPGQARPDWEIVQDIAQRVGLDWAYGSPSEVFDEMVALMPSYANLAHGNLGSSGKLYPNSDPEHTDGTVVMFVERFNTDDGLAHLVPAQWLPPKELPDGEYPLVLNTGRLLEHWHTGSMTRRSYALDAISPVAEVYMHPKDAAERGMAHGQRVRARSRRGEIELQVRISHREQLGNVFIPFHFREAAANLLTIDEVDPFGKIPEFKFCAVQVEVL

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Crispr_ID: NZ_CP053564_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053564_8

5417846-5417939

Orphan

Consensus_repeat	Method
GCGCCTCCGGCACCCGTGAGTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP053564_8

>merge|NZ_CP053564|8|5417846-5417939|CRISPRCasFinder
GCGCCTCCGGCACCCGTGAGTGGCAACCGTGGCCAGGGCCACGATCGCCACTCACGACCGTCACCCCACGGGCGCCTCCGGCACCCGTGAGTGG

>NZ_CP053564|8|5|5417846-5417939|CRISPRCasFinder
GCGCCTCCGGCACCCGTGAGTGG	CAACCGTGGCCAGGGCCACGATCGCCACTCACGACCGTCACCCCACGG
GCGCCTCCGGCACCCGTGAGTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053564.1\|WP_172163243.1\|5413694_5414651_-\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|376566
NZ_CP053564.1\|WP_172163213.1\|5411500_5411698_-\|DUF2795-domain-containing-protein	unknown	unknown	gnl\|CDD\|378655
NZ_CP053564.1\|WP_172163259.1\|5418796_5419567_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187629
NZ_CP053564.1\|WP_172163268.1\|5422145_5422907_+\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|180591
NZ_CP053564.1\|WP_172163271.1\|5422910_5423558_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP053564.1\|WP_172163205.1\|5408247_5408430_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053564.1\|WP_172163277.1\|5424179_5424641_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP053564.1\|WP_172163219.1\|5412927_5413698_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235546
NZ_CP053564.1\|WP_172163265.1\|5420356_5422084_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|181381
NZ_CP053564.1\|WP_172163283.1\|5425247_5426375_-\|spore-photoproduct-lyase-family-protein	unknown	unknown	gnl\|CDD\|188401
NZ_CP053564.1\|WP_172163249.1\|5415607_5416738_-\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|235874
NZ_CP053564.1\|WP_172163216.1\|5411761_5412916_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|224423
NZ_CP053564.1\|WP_172163262.1\|5419567_5420347_+\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|226098
NZ_CP053564.1\|WP_172163246.1\|5414650_5415589_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319904
NZ_CP053564.1\|WP_172163211.1\|5410132_5410468_+\|DUF3140-domain-containing-protein	unknown	unknown	gnl\|CDD\|371477
NZ_CP053564.1\|WP_172163274.1\|5423593_5424082_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053564.1\|WP_172163280.1\|5424771_5425161_+\|group-1-truncated-hemoglobin	unknown	unknown	gnl\|CDD\|381253
NZ_CP053564.1\|WP_172163256.1\|5417975_5418731_-\|2,4-dihydroxyhept-2-ene-1,7-dioic-acid-aldolase	unknown	unknown	gnl\|CDD\|226356
NZ_CP053564.1\|WP_172163252.1\|5416763_5417753_-\|cyclase-family-protein	unknown	unknown	gnl\|CDD\|377240
NZ_CP053564.1\|WP_172163208.1\|5408603_5410184_+\|polyprenol-phosphomannose-dependent-alpha-1,6-mannosyltransferase-MptB	unknown	unknown	gnl\|CDD\|274589

Protein	Function_ID	Function_description	E-value
NZ_CP053564.1\|WP_172163243.1\|5413694_5414651_-\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|376566	pfam01557, FAA_hydrolase, Fumarylacetoacetate (FAA) hydrolase family. This family consists of fumarylacetoacetate (FAA) hydrolase, or fumarylacetoacetate hydrolase (FAH) and it also includes HHDD isomerase/OPET decarboxylase from E. coli strain W. FAA is the last enzyme in the tyrosine catabolic pathway, it hydrolyzes fumarylacetoacetate into fumarate and acetoacetate which then join the citric acid cycle. Mutations in FAA cause type I tyrosinemia in humans this is an inherited disorder mainly affecting the liver leading to liver cirrhosis, hepatocellular carcinoma, renal tubular damages and neurologic crises amongst other symptoms. The enzymatic defect causes the toxic accumulation of phenylalanine/tyrosine catabolites. The E. coli W enzyme HHDD isomerase/OPET decarboxylase contains two copies of this domain and functions in fourth and fifth steps of the homoprotocatechuate pathway; here it decarboxylates OPET to HHDD and isomerises this to OHED. The final products of this pathway are pyruvic acid and succinic semialdehyde. This family also includes various hydratases and 4-oxalocrotonate decarboxylases which are involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. 2-hydroxypentadienoic acid hydratase encoded by mhpD in E. coli is involved in the phenylpropionic acid pathway of E. coli and catalyzes the conversion of 2-hydroxy pentadienoate to 4-hydroxy-2-keto-pentanoate and uses a Mn2+ co-factor. OHED hydratase encoded by hpcG in E. coli is involved in the homoprotocatechuic acid (HPC) catabolism. XylI in P. putida is a 4-Oxalocrotonate decarboxylase.	7.38278e-65
NZ_CP053564.1\|WP_172163213.1\|5411500_5411698_-\|DUF2795-domain-containing-protein	gnl\|CDD\|378655	pfam11387, DUF2795, Protein of unknown function (DUF2795). This family of proteins has no known function.	1.74237e-06
NZ_CP053564.1\|WP_172163259.1\|5418796_5419567_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187629	cd05371, HSD10-like_SDR_c, 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs. HSD10, also known as amyloid-peptide-binding alcohol dehydrogenase (ABAD), was previously identified as a L-3-hydroxyacyl-CoA dehydrogenase, HADH2. In fatty acid metabolism, HADH2 catalyzes the third step of beta-oxidation, the conversion of a hydroxyl to a keto group in the NAD-dependent oxidation of L-3-hydroxyacyl CoA. In addition to alcohol dehydrogenase and HADH2 activites, HSD10 has steroid dehydrogenase activity. Although the mechanism is unclear, HSD10 is implicated in the formation of amyloid beta-petide in the brain (which is linked to the development of Alzheimer's disease). Although HSD10 is normally concentrated in the mitochondria, in the presence of amyloid beta-peptide it translocates into the plasma membrane, where it's action may generate cytotoxic aldehydes and may lower estrogen levels through its use of 17-beta-estradiol as a substrate. HSD10 is a member of the SRD family, but differs from other SDRs by the presence of two insertions of unknown function. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.42733e-107
NZ_CP053564.1\|WP_172163268.1\|5422145_5422907_+\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|180591	PRK06494, PRK06494, enoyl-CoA hydratase; Provisional.	8.5518e-68
NZ_CP053564.1\|WP_172163271.1\|5422910_5423558_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.75661e-11
NZ_CP053564.1\|WP_172163277.1\|5424179_5424641_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	8.31409e-21
NZ_CP053564.1\|WP_172163219.1\|5412927_5413698_-\|SDR-family-oxidoreductase	gnl\|CDD\|235546	PRK05653, fabG, 3-oxoacyl-ACP reductase FabG.	1.67239e-69
NZ_CP053564.1\|WP_172163265.1\|5420356_5422084_-\|AMP-binding-protein	gnl\|CDD\|181381	PRK08316, PRK08316, acyl-CoA synthetase; Validated.	1.74521e-123
NZ_CP053564.1\|WP_172163283.1\|5425247_5426375_-\|spore-photoproduct-lyase-family-protein	gnl\|CDD\|188401	TIGR03886, hypothetical_protein_SlinDRAFT_56750, spore photoproduct lyase family protein. This uncharacterized radical SAM domain protein occurs rarely and sporadically in species that include select Alphaproteobacteria and Actinobacteria, and in Deinococcus deserti VCD115. It is a distant but full-length homolog to the Bacillus subtilis spore photoproduct lyase (spl), which monomerizes thymine dimers created as DNA damage by uv radiation.	0
NZ_CP053564.1\|WP_172163249.1\|5415607_5416738_-\|FAD-dependent-monooxygenase	gnl\|CDD\|235874	PRK06847, PRK06847, hypothetical protein; Provisional.	3.44179e-160
NZ_CP053564.1\|WP_172163216.1\|5411761_5412916_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	5.53423e-12
NZ_CP053564.1\|WP_172163262.1\|5419567_5420347_+\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|226098	COG3568, ElsH, Metal-dependent hydrolase [General function prediction only].	1.80894e-15
NZ_CP053564.1\|WP_172163246.1\|5414650_5415589_-\|VOC-family-protein	gnl\|CDD\|319904	cd07239, BphC5-RK37_C_like, C-terminal, catalytic domain of BphC5 (2,3-dihydroxybiphenyl 1,2-dioxygenase). 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC) catalyzes the extradiol ring cleavage reaction of 2,3-dihydroxybiphenyl, the third step in the polychlorinated biphenyls (PCBs) degradation pathway (bph pathway). The enzyme contains a N-terminal and a C-terminal domain of similar structure fold, resulting from an ancient gene duplication. BphC belongs to the type I extradiol dioxygenase family, which requires a metal in the active site for its catalytic activity. Polychlorinated biphenyl degrading bacteria demonstrate multiplicity of BphCs. Bacterium Rhodococcus rhodochrous K37 has eight genes encoding BphC enzymes. This family includes the C-terminal domain of BphC5-RrK37. The crystal structure of the protein from Novosphingobium aromaticivorans has a Mn(II)in the active site, although most proteins of type I extradiol dioxygenases are activated by Fe(II).	5.97503e-72
NZ_CP053564.1\|WP_172163211.1\|5410132_5410468_+\|DUF3140-domain-containing-protein	gnl\|CDD\|371477	pfam11338, DUF3140, Protein of unknown function (DUF3140). Some members in this family of proteins are annotated as DNA binding proteins. No function is currently known.	1.1739e-43
NZ_CP053564.1\|WP_172163280.1\|5424771_5425161_+\|group-1-truncated-hemoglobin	gnl\|CDD\|381253	cd00454, TrHb1_N, truncated hemoglobins (TrHbs, 2/2Hb, 2/2 globins); group 1 (N). The M- and S families exhibit the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments. Truncated hemoglobins (TrHbs, 2/2Hb, or 2/2 globins) or T family globins adopt a 2-on-2 alpha-helical sandwich structure, resulting from extensive and complex modifications of the canonical 3-on-3 alpha-helical sandwich that are distributed throughout the whole protein molecule. They are classified into three main groups based on their structural properties and named after Mycobacterium sp. genes glbN, glbO, and glbP: TrHb1s (N), TrHb2s (O) and TrHb3s (P). Typical of the TrHb1s (N) group is a protein matrix tunnel. It includes a Mycobacterium tuberculosis TrHb1, Mt-trHbN, which is encoded by the glbN gene. Mt-trHbN is expressed during the Mycobacterium stationary phase, and plays a specific defense role against nitrosative stress. The cyanobacterium Synechococcus sp. PCC 7002 TrHb1 GlbN, is constitutively expressed, and likely also protects cells from reactive nitrogen species.	9.07461e-29
NZ_CP053564.1\|WP_172163256.1\|5417975_5418731_-\|2,4-dihydroxyhept-2-ene-1,7-dioic-acid-aldolase	gnl\|CDD\|226356	COG3836, HpcH, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism].	4.51081e-40
NZ_CP053564.1\|WP_172163252.1\|5416763_5417753_-\|cyclase-family-protein	gnl\|CDD\|377240	pfam04199, Cyclase, Putative cyclase. Proteins in this family are thought to be cyclase enzymes. They are found in proteins involved in antibiotic synthesis. However they are also found in organisms that do not make antibiotics pointing to a wider role for these proteins. The proteins contain a conserved motif HXGTHXDXPXH that is likely to form part of the active site.	3.08546e-15
NZ_CP053564.1\|WP_172163208.1\|5408603_5410184_+\|polyprenol-phosphomannose-dependent-alpha-1,6-mannosyltransferase-MptB	gnl\|CDD\|274589	TIGR03459, crt_membr, carotene biosynthesis associated membrane protein. This model represents a family of hydrophobic and presumed membrane proteins found in the Actinobacteria. The genes encoding these proteins are syntenically associated with (found proximal to) genes of carotene biosynthesis ususally including phytoene synthase (crtB), phytoene dehydrogenase (crtI) and geranylgeranyl pyrophosphate synthase (ispA).	5.2052e-59

>NZ_CP053564.1|WP_172163252.1|5416763_5417753_-|cyclase-family-protein
MTHLPDRTDPEGAIAAAAKLCSNRDRWGADDVLGTLNFLDEAKRREGAALVRRGTSFSLAQSFDGNGPQKGWRRRTNPVHTMLDTGVDAERGTQGFPHGIGGADDVVFMPLQASTQWDGLGHIFDHGQAYNGRRAGDVVTSEGDRVTGIETTAGLIAGRGVLLDVGRAIGTDGELPDGFAITVEHLEATIAAQGPSAHVGRGDLLLVRTGRLTRARRDIAQGLGWGDYAGGDAPGLSFTTAEWLHASEIAGIATDTWGFEVRPNEFDVAFQPLHQVAIPHMGLFLGEMWDLDALAADCAVDGVFDFWLTAAPLPVTGAVGAPVAPIAVK
>NZ_CP053564.1|WP_172163249.1|5415607_5416738_-|FAD-dependent-monooxygenase
MPAVSTVLVVGSGLAGSAAAILLAARGVAVDVVEINPGVPDAGSGITLQGNALRELRALGVWERVAERGYGFDSLGLRAPDADGTLLAEIPDARTGGPDLPATVGMSRPELARILLDRAADAGVKTRFGVTTTALEQDATGVDVTFSDGSAQRYDLVVGADGIRSWTRRMLGIALETRATGMGIWRAFGPRPASVTRTDLFYGGRCHIAGYCPTGEDSLYAYVVEDAQDRSTLTPDERLAAMRELAAGYHGPWDDVLATLDDPERVHYTWFETHVLPAPWNRGRVVLIGDAAHSCPPTLAQGGAQALEDAAVLAELLLAADVLDEDLWDAFTARRVARATAVVEASNQLGQWLLDGERGDVPGLMGRIAALVTEPA
>NZ_CP053564.1|WP_172163246.1|5414650_5415589_-|VOC-family-protein
MTDRLITHLRHVDLAVPDLARQQDFFTNSWGLRTEHGEPGLSFLAAEGSPEQYVVRLRQSGDKRVDLVAFGAASAADVDALAARLGTDGVTLVTEPGTLQTPGGGYGFRFFDNEGRTVEVSADVAVRAHRRIEEGEPVPVRLSHVVLNSADPEGTRAFYERHLGFALSDTLTHPRMGDMMWFMRINRWHHSVAIARGPHPSLHHLSFELRGLDEYMRGTGKLLRAGVEKIWGPGRHLAGNNTFSYFLDPHGNTVEYTTELEEIDEDTWHPHVYDFTRPEVSDQWGTANAMNEFVASRSFNDVDKGLFVAPPV
>NZ_CP053564.1|WP_172163243.1|5413694_5414651_-|fumarylacetoacetate-hydrolase-family-protein
MRLATYEHAGSVGCGVVQGDGIHPFPDGTTVLDLVRSGLAAALEVGERARQTPPVPLDTVRLLPPLDPPTVRDFVAFEEHVEGVVASVGDGGGVVPQWYEAPTFYFTNPCALVGAHDDVAVPPGSELFDFELEVAAVVGRDAASPTPAEVQVFGYTVLNDWSARDLQRREMKVNLGPAKGKDSATTLGPWLVTADELEPFRDADGFLALDMRVSVNGEQVGQDLLSNMGWPFEELVAYAGRGTRVRAGDVLGSGTCGNGGCLAELWGRRGEQNPPPLRPGDVVEMTVEGIGTIRNTVVAGVDLPPVAPARPRPRRRVR
>NZ_CP053564.1|WP_172163219.1|5412927_5413698_-|SDR-family-oxidoreductase
MTGRVAGKVVVVTGAGGGQGAAEARLLAAEGASVVALDVTPAPAEDLPGVAYRRLDVTDATGWAVLAEELRRDHGRVDGLVANAGITWRARLADLDAADLARVHEVNVGGVLLGVQALLPLMGPGSSIVTVGSAAALTGHYPLAYTASKWALRGLTKAACLELGPRGIRVNAVHPGFIETPMTASAAPAFRDANVRETPLGRTGTVDEVAPLVVFLVSDDAAFVSGAEIPVDGGLTAHGGVKSISDALRPSEPSPV
>NZ_CP053564.1|WP_172163216.1|5411761_5412916_-|alpha/beta-fold-hydrolase
MFEYFPGNYVWNLGVVAALNSGGLIDEVDRACRPIREAAAQGADAGTPDFLRAWTALTDRLVAQAEEAEKDGNTRTAGQLYFRATNYLCQAERMLSHSDPDRVPTYRRVLELAQKAFDLRDPRITRVAIPYEGTTLPAYFSAAPATDDGPAPVIVLVNGLDSAKEHMYGSGHWEELAARGISCLMLDQPGTGEALRLQGLTARIDTEAWAGAAVDWLETRDDVDATRIGITGWSLGGYYAPRAAAYEERFALCVAWGANHDWGAVQRRRLEREGERPVPHYWEHVLWVWGHDDLDAFIDFADAVNLEGVVERIRVPFLVAHGENDRQIPVAYAHRSYDQAVHSPRRELRIFTPEEGATEHIGLDHLPHVSSWIADWVAARFAGR
>NZ_CP053564.1|WP_172163213.1|5411500_5411698_-|DUF2795-domain-containing-protein
MSFQVTEVQKALKGADYPMDGAALADLAESNGADKELVDALRPMREVDGPNGVMKELKGQLGGDA
>NZ_CP053564.1|WP_172163211.1|5410132_5410468_+|DUF3140-domain-containing-protein
MDDDEAKQIRADFSDAVNMSGRELREWLETDDSEAVGDHKDGGEAVGHEMGRHIVELQGTKAGDLTDEDLARMRKVVGYVHRHLAQRPKGDVTDTRWRYSLMNWGHDPLKD
>NZ_CP053564.1|WP_172163208.1|5408603_5410184_+|polyprenol-phosphomannose-dependent-alpha-1,6-mannosyltransferase-MptB
MTGPATGPATGVAADGMLRARLLGTTGALLVALGALGAGALPVPHPLAGLRLVGLPARTATLSLALAWAGAALLVLAWLQVSRRVRAGGPLAPSRAELGRTALLWALPLAIAPPVFSRDVYSYLAQGAVLARGLDPYALGPAEALGMDDPLVRSIPAMWRDTPSPYGPLFLGLARGVAVLAGDDVALGVLVHRVLALAGLALVVAALPALARRCGVDPRYALWCGAAHPLVLFHLVGGVHNDALMLGLLLAGLELGLRAGERLLDGRLLAGAVLVVAASAVKLPALVALGVLGAVRARGGGWRAVAAQTGVLGAVAVAGLAVCTAATGAGPGWLAALGVPGSIDSPFSPTTDLGYAAGVLGVLAGLGDHTATAVALVRAIGLVAGAGVVGAALLAVRGGRLDPVAGLGASLAAVVLLGPAGQPWYLLWALVPLVATPALPRLRRALLAVSVPLALVLAPTGGLFPFHGFQPALAVIAALLLVACSVWGTDRWYRPSERGIRAAGRGTRPAWTTTRRSRSAPTSPTP
>NZ_CP053564.1|WP_172163205.1|5408247_5408430_+|hypothetical-protein
MHDWLCERCGDSILPQAPCRCATPYDPVAVRRRHRDAVRLARSTDRRRAAMRRAGQRPAA
>NZ_CP053564.1|WP_172163256.1|5417975_5418731_-|2,4-dihydroxyhept-2-ene-1,7-dioic-acid-aldolase
MTQTPSASGVRAAWAAGRAARNGWITVPDPHLVEVVASRGVLDAVTLDLQHGLFDRASTAAAVRAAALHGTAVLVRLSAVDAAEAGFVLDLGVQGVIAPMVDDVATARALVDACRLPPLGRRSYGPIRTAFGGADPVAAAGQALVFAMVETAGALERAGEIAAVEGLDGLFVGPGDLGVALGLGAAQNREEPEIHDAFARVLAACGAAGGRAGVHATSADYAKARADDGFGLVTVWSDLPALAASVDASTW
>NZ_CP053564.1|WP_172163259.1|5418796_5419567_+|SDR-family-NAD(P)-dependent-oxidoreductase
MEISGASAVVTGGASGLGAATARRLAERGAHVVVLDLQEELGSAVAAEIGGVFAKADVADEEQVRAAVDAASELGPLRVLVNSAGLGRAGRIIGRDLSPIPLEQFEFVLRVNLVGTYNCSRLAASAMAATEPLADGTSRGAILHTASAAAFDGQIGQTPYSASKGGVVGMTLPMARDLARHGIRVNTIAPGLIDTPIYGTGEQAEAFKAQLGQSVVYPNRLGTADEYASMAVEILTNDYMNGETVRLDGAIRMPPK
>NZ_CP053564.1|WP_172163262.1|5419567_5420347_+|endonuclease/exonuclease/phosphatase-family-protein
MRVATLNLASGRDATGRSLDAAALAAALDGFGADVVAVQEVDRDQPRSHGVDQPAVVARALEAVDWRWAPTVAGTPGPQHTWRAVDPTALHGPGDGPAGPHYGIALFSRRPVRRWHVLDLGTGRGRLPVPTGRESPRLDWVSDEPRAAVAAELDGLTVVGTHLSFAPITAGRQLVRIRDWARGLPGPVVVAGDLNLVGPVPELVSGGTRLVRKPTFPAHDPRVQLDHVLALGDLRGGDARAWRLAFGDHRAVAVTLRPL
>NZ_CP053564.1|WP_172163265.1|5420356_5422084_-|AMP-binding-protein
MSERRSLPGLVLRPGSRDAGAVQPGASDIDVTNLRGRRAVHRWERTSVGDVLERLTWSYPDKVAITGWAGAYSDDRFRTLTFRQADELANQVAHALLERGLEPSSRVLLLCENSVEAYVAKIGIAKAGMVAMPLNPALAPDVLEHLIARAEPAFAIVDAELWPRAEQAFAARGLAVGATIPIGGGAVAGSPTFAELVDGRPVTEPDVEIHGDDVWQLLFTSGTTAMPKGVMLSHSASHLAGLNFAVSLSRGLRIESDLVVGVFLPVVYHVADQIFTFSAFLAGGSLVLGRRPVPAEVARAVEVERVTALWAGSPQFVTALTTELDAAGHDWSSLRVLVFGWGALAPATYRALLRHAGDDLVVLGIFGQTEAIACHRFWPARWPEQAATGLNYVGVPSPLLASDVVDELGESLRDRPGTAGEAVYRSPIVTAGYHLDEAATREAFRGGWFHSGDSTSVDADGLRIMVDRFKDIVKSGGENVSSLRVESVLHDHPAVERVAVVGLPHPHWGEAVTAVVVRRAGVETTEEDVIAHCRARLAGYETPKGVVFADDLPETVGGKVLKYRLRERHRDLYSG
>NZ_CP053564.1|WP_172163268.1|5422145_5422907_+|enoyl-CoA-hydratase/isomerase-family-protein
MGPVTYEVTAGVAWLTIDRPEAHNALSRPVREGLFDGVHRFNADDAARVLVLTGAGEKAFCSGGDLKEMSETALTVPPPDFLPQFGRNVEVAKPTIAAVNGIAYGGGFLLAQQCDLVVAAEHARFAVSEVKVGRGSPWAAPLSWLVPPRVALQILLTGDPLDAARAREVGLVNEVVPLPDLRATAQALAERIAANAPLSVLAAKRTAYLSASHPRAEAYDRAEEIWEPVYLSEDAQEGPRAFREKRAPVWRGR
>NZ_CP053564.1|WP_172163271.1|5422910_5423558_-|TetR/AcrR-family-transcriptional-regulator
MEPVGSGIPSRGRRDPDRKARILEAAGALIARSGYHRVAMADIGAAAGIVGSGIYRHFDSKAAILAALLQEVMDELERSAAAIVESADDDRTALGELVRNHVEIAVTDRRILQVYHREAHNLPEQSLRRLRRAQRHYVEEWVAVLGPLRRDLADGEARLTVHATIGAIQSVLFHDSGLPHARLTALLAGMAHACLGVGPERVGPERVGPERVGPE
>NZ_CP053564.1|WP_172163274.1|5423593_5424082_-|hypothetical-protein
MSECYAPEPLIETTDAVDSESTDHGSGYETGHDSSEGHDTSDSHDSGYEGDESHQSYEYADVDGDGYEETTLVDSNGDGEVDTVLSDVDGDYYDDVALFENVPGAAPFVPDVVAVALDADGLADIVLDDTDLDGIFDVVSSGYDAPLADANPYAIPAGVPGA
>NZ_CP053564.1|WP_172163277.1|5424179_5424641_-|MarR-family-transcriptional-regulator
MSRSPRSEFVLDEQLCFALYTASRAMTGAYRDGLARLGLTYTQYLVLLLLWEHGSLPMGHICERLHLDSATLSPLLKRLAGEGLITRERSQLDERVVDITCTREGHALRDRVHEVQCDVEDSTGLSADELATMRADLHRMAGRLREHPAVHRS
>NZ_CP053564.1|WP_172163280.1|5424771_5425161_+|group-1-truncated-hemoglobin
MTDASLYERLGGTYGIAGAVDVLVDRLFANASVNANAAVHDHHGDPANAAGYKFLVTAWSIEAAGGPACYPGKGMDEAHATLAISEADFDAVALEIASTLNFLGVPAGEHQEFMAIIEGYRPQVVAAAV
>NZ_CP053564.1|WP_172163283.1|5425247_5426375_-|spore-photoproduct-lyase-family-protein
MSSPSATAGAVTPPDASTTPTTAADRLLRIGAVYAEPEARDSERGQQVLSRFPGAEVIEVPSHWQIPELHGNEGNVERWVRVKSGTLVLGVKKSLSARPNGRSSDFIAPSTSNGCAMACAYCYVPRRKGYANPITVFTNIDKITRYLRGHVRRQGVKPEPDQVDPRAWVYDIGENSDCSVDALVSDNVADLVATFRELPTAKASFATKFVNRELLDLDPQGRTRVRFSLMPESDAKLLDIRTSPIPERIAAIDDFVAAGYEVHLNFSPIVLREGWERDWAELLTRLDDEVGDAAKQQAAAEIIMLTHNRDLHEVNLGWHPKAEDLLWRPDIQQPKRSQSGMWNVRYRNAPKREAVARVQDLIAAHAPWIRVRYAF

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Crispr_ID: NZ_CP053564_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053564_9

5970738-5970844

Orphan

Consensus_repeat	Method
GTCACGTCACACTCCCGGCGATCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP053564_9

>merge|NZ_CP053564|9|5970738-5970844|CRISPRCasFinder
GTCACGTCACACTCCCGGCGATCACCGCTCACCCTCTGCCCTTGATCACCGAGACCGTGACGGGAAGGTCGCGGCGAGGGCTGTCAGGTCACACTCCCGGCGATCAC

>NZ_CP053564|9|6|5970738-5970844|CRISPRCasFinder
GTCACGTCACACTCCCGGCGATCAC	CGCTCACCCTCTGCCCTTGATCACCGAGACCGTGACGGGAAGGTCGCGGCGAGGGCT
GTCAGGTCACACTCCCGGCGATCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053564.1\|WP_172164708.1\|5980998_5981298_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053564.1\|WP_172169431.1\|5975878_5976667_+\|poly(3-hydroxyalkanoate)-depolymerase	unknown	unknown	gnl\|CDD\|131294
NZ_CP053564.1\|WP_172169425.1\|5968756_5969569_-\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|227339
NZ_CP053564.1\|WP_172164702.1\|5979840_5980686_+\|ribokinase	unknown	unknown	gnl\|CDD\|238571
NZ_CP053564.1\|WP_172164699.1\|5978905_5979844_+\|pseudouridine-5'-phosphate-glycosidase	unknown	unknown	gnl\|CDD\|377251
NZ_CP053564.1\|WP_172164684.1\|5969912_5970098_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053564.1\|WP_172164675.1\|5964029_5965484_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226669
NZ_CP053564.1\|WP_172164693.1\|5978009_5978633_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|372616
NZ_CP053564.1\|WP_172164678.1\|5965483_5966257_-\|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224053
NZ_CP053564.1\|WP_172164696.1\|5978658_5978907_-\|DUF3039-domain-containing-protein	unknown	unknown	gnl\|CDD\|378609
NZ_CP053564.1\|WP_172164669.1\|5961100_5962102_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|378117
NZ_CP053564.1\|WP_172164672.1\|5962316_5962634_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053564.1\|WP_172169428.1\|5971276_5972950_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223989
NZ_CP053564.1\|WP_172164705.1\|5980675_5981002_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053564.1\|WP_172164681.1\|5966327_5967443_-\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|380650
NZ_CP053564.1\|WP_172169422.1\|5967690_5968653_+\|polyphosphate-kinase-2	unknown	unknown	gnl\|CDD\|213852
NZ_CP053564.1\|WP_172164690.1\|5974148_5975849_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|130898
NZ_CP053564.1\|WP_172169417.1\|5960285_5961092_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223673
NZ_CP053564.1\|WP_172169420.1\|5962810_5963986_-\|ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224851
NZ_CP053564.1\|WP_172164687.1\|5973114_5974152_+\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|377085

Protein	Function_ID	Function_description	E-value
NZ_CP053564.1\|WP_172164702.1\|5979840_5980686_+\|ribokinase	gnl\|CDD\|238571	cd01166, KdgK, 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources.	7.19411e-56
NZ_CP053564.1\|WP_172169425.1\|5968756_5969569_-\|EamA-family-transporter	gnl\|CDD\|227339	COG5006, rhtA, Threonine/homoserine efflux transporter [Amino acid transport and metabolism].	6.29328e-53
NZ_CP053564.1\|WP_172164699.1\|5978905_5979844_+\|pseudouridine-5'-phosphate-glycosidase	gnl\|CDD\|377251	pfam04227, Indigoidine_A, Indigoidine synthase A like protein. Indigoidine is a blue pigment synthesized by Erwinia chrysanthemi implicated in pathogenicity and protection from oxidative stress. IdgA is involved in indigoidine biosynthesis, but its specific function is unknown. The recommended name for this protein is now pseudouridine-5'-phosphate glycosidase.	2.51253e-149
NZ_CP053564.1\|WP_172164675.1\|5964029_5965484_-\|ABC-transporter-permease	gnl\|CDD\|226669	COG4214, XylH, ABC-type xylose transport system, permease component [Carbohydrate transport and metabolism].	6.57707e-64
NZ_CP053564.1\|WP_172164693.1\|5978009_5978633_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|372616	pfam13489, Methyltransf_23, Methyltransferase domain. This family appears to be a methyltransferase domain.	2.74838e-09
NZ_CP053564.1\|WP_172164690.1\|5974148_5975849_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|130898	TIGR01839, Poly3-hydroxyalkanoate_polymerase_1, poly(R)-hydroxyalkanoic acid synthase, class II. This model represents the class II subfamily of poly(R)-hydroxyalkanoate synthases, which polymerizes hydroxyacyl-CoAs, typically with six to fourteen carbons in the hydroxyacyl backbone into aliphatic esters termed poly(R)-hydroxyalkanoic acids. These polymers accumulate as carbon and energy storage inclusions in many species and can amount to 90 percent of the dry weight of cell. [Fatty acid and phospholipid metabolism, Biosynthesis].	1.11874e-172
NZ_CP053564.1\|WP_172164696.1\|5978658_5978907_-\|DUF3039-domain-containing-protein	gnl\|CDD\|378609	pfam11238, DUF3039, Protein of unknown function (DUF3039). This family of proteins with unknown function appears to be restricted to Actinobacteria.	2.08071e-26
NZ_CP053564.1\|WP_172164669.1\|5961100_5962102_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|378117	pfam09084, NMT1, NMT1/THI5 like. This family contains the NMT1 and THI5 proteins. These proteins are proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine. They are regulated by thiamine. The protein adopts a fold related to the periplasmic binding protein (PBP) family. Both pyridoxal-5'-phosphate (PLP) and an iron atom are bound to the protein suggesting numerous residues of the active site necessary for HMP-P biosynthesis. The yeast protein is a dimer and, although exceptionally using PLP as a substrate, has notable similarities with enzymes dependent on this molecule as a cofactor.	2.71334e-62
NZ_CP053564.1\|WP_172169420.1\|5962810_5963986_-\|ROK-family-transcriptional-regulator	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	4.2086e-46
NZ_CP053564.1\|WP_172169428.1\|5971276_5972950_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	3.71556e-63
NZ_CP053564.1\|WP_172164681.1\|5966327_5967443_-\|substrate-binding-domain-containing-protein	gnl\|CDD\|380650	cd19995, PBP1_ABC_xylose_binding-like, periplasmic xylose-like sugar-binding component of the ABC-type transport systems. Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes a transition from an open to a closed conformational state upon ligand binding. Moreover, the periplasmic xylose-binding protein is homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR.	9.01487e-92
NZ_CP053564.1\|WP_172169422.1\|5967690_5968653_+\|polyphosphate-kinase-2	gnl\|CDD\|213852	TIGR03707, PPK2_P_aer, polyphosphate kinase 2, PA0141 family. Members of this protein family are designated polyphosphate kinase 2 (PPK2) after the characterized protein in Pseudomonas aeruginosa. This family comprises one of three well-separated clades in the larger family described by pfam03976. PA0141 from this family has been shown capable of operating in reverse, with GDP preferred (over ADP) as a substrate, producing GTP (or ATP) by transfer of a phosphate residue from polyphosphate. Most species with a member of this family also encode a polyphosphate kinase 1 (PPK1). [Central intermediary metabolism, Phosphorus compounds].	9.74675e-154
NZ_CP053564.1\|WP_172169431.1\|5975878_5976667_+\|poly(3-hydroxyalkanoate)-depolymerase	gnl\|CDD\|131294	TIGR02240, Poly3-hydroxyalkanoate_depolymerase, poly(3-hydroxyalkanoate) depolymerase. This family consists of the polyhydroxyalkanoic acid (PHA) depolymerase of Pseudomonas oleovorans, Pseudomonas putida BM01, and related species. This enzyme is part of polyester storage and mobilization system as in many bacteria. However, species containing this enzyme are unusual in their capacity to produce aromatic polyesters when grown on carbon sources such as benzoic acid or phenylacetic acid. [Energy metabolism, Other].	7.72611e-84
NZ_CP053564.1\|WP_172169417.1\|5960285_5961092_-\|ABC-transporter-permease	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	2.1761e-63
NZ_CP053564.1\|WP_172164678.1\|5965483_5966257_-\|sugar-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	4.43824e-105
NZ_CP053564.1\|WP_172164687.1\|5973114_5974152_+\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	3.29111e-40

>NZ_CP053564.1|WP_172164684.1|5969912_5970098_+|hypothetical-protein
MQPGTLTRPELTLADRCDRCGAAAKVRAILPSGGELLFCGHHGRAHADKLRELEASVETGS
>NZ_CP053564.1|WP_172169425.1|5968756_5969569_-|EamA-family-transporter
MYVGAALAVGLFDVLPPTVVALLRLLGAAAVLLAWRRPGRAAWRGSRLARASAFGLATALMNLAFYEAIARLPLGTAVAVEFVGPVAVAAVASRRPRDVAAVALAALGVALIADVRWSGSPSGVLWALAAAGMWAAYILLGKRVATAGNGLDDMAVGFTVAAVLLSPLLMVGGPTALGALADPAVLLLAVGVGVLSSVVPYVLDQLVLRRVGQARFAVLLALLPATATVVGLVALAQVPGLLEGAGIAAVIAAVALRSRDGDVVPDADPR
>NZ_CP053564.1|WP_172169422.1|5967690_5968653_+|polyphosphate-kinase-2
MPTGDRARVDLPDLLADHSALRVDDSDDDDPVLVGPDGAHVDTWREGYPYDERLSRAEYDRGKRLLQIELLKLQNWVKETGQRVVILFEGRDAAGKGGTIKRFMEHLNPRGARVVALEKPTERESTQWYFQRYVAHLPAAGEIVLFDRSWYNRAGVERVMGFAEAREYMEFMREAPELERMFVRSGIHLVKLWFSVSQNEQRTRFTIRQVDPVRQWKLSPMDLASLDKWAAYTEAKEAMFFYTDTADAPWTVIKSNDKKRARLEAMRHVLRLFDYPGKDLDVATDPDRLIVGPAAEVFEFGERPGHFPALSARLRTPGPG
>NZ_CP053564.1|WP_172164681.1|5966327_5967443_-|substrate-binding-domain-containing-protein
MRTRRTAQLALGLGVALTLAACGQNAAAPTAAPGAEVAEDAPRVGVILPETESSARWEGFDRPLLTAAMAEAGLDADIQNAQGDEQTFTTLADGFIASGVDVLVIAAITSESGAAVAAKAKAQGIPTIDYDRLSLGGSSDYYVSFDNEGVGALQGEGLAQALTGAQGAQVIEIRGAPTDNNATLFYNGAQTVLKPLYDSGALSLVASQPIEDWDNQIGGTTFEQLLTSNGGQVGGVLAANDGLAGAIITVLQKYGLNGSVPVTGQDATPDGLQAILRGDQYMTVYKPIQEEAQATAELAAALAKDDTAAADAIATDTVDDPEGNRQVKSVLLTPQLITRDNVKTVIDDGAVPASEVCVADLAAVCTELGIS
>NZ_CP053564.1|WP_172164678.1|5965483_5966257_-|sugar-ABC-transporter-ATP-binding-protein
MSDPILQLRGVNKSFGAVQVLHDVDFTVRAGEVTALVGDNGAGKSTLVKCVAGIHPTDSGEVLFDGQPATVAAPADAAKLGIEVVYQDLALADNLDIVQNMFLGRERGKPWLLDEADMEQAARDTLASLSVRTVTSVRMPVAALSGGQRQTVAIAKAVLWDSKVVLLDEPTAALGVAQTRQVLDLVRRLAEQGLGVVLISHNMADVFEVSDRIACLYLGRMVAQVPTKDVSHGQVVELITAGRSGDLGLQRPEAVTV
>NZ_CP053564.1|WP_172164675.1|5964029_5965484_-|ABC-transporter-permease
MSAPEKPDLEKKSAAERAAPASSRAADFGIDTTARTTGQAVAAYLRGLRTGELGALPALLGLLVLLVLFSVLDSTGTFPSLLNLANLLQQGAGRTIIAMGLVFVLLTGEIDLAAGTASGLAAAVMALHLVSGGNLLGGMGTTVFVLFLLVVVLAIVLALLLRIWAGAVLSAVALLLLVIGFPPNPWLQMLLAVCVGVVIGCITGFLVARVGMPSFVVTLALFIAWQGIILALIGDGGTLGLRDPVINAVANGNLSTLGSWVLFVVAAGGYAAVLLNRQVSRRKLGLVAQPTGLVLIKVGAVVVLGAIATFLLTLNRSPGDTLIEGVPFVVPIVLALLVIGTYVLDRTRFGRHVYAVGGNREAARRAGIDVVRIRASVFVIASAFAAIGAIVYSSKVGSVSPGAGGGNTLLFAVGAAVIGGTSLFGGRGRISNAVIGGAVLATVENGLGLLRQPAAVVFVVTGLVLLLAASVDVLSRRRSAVAGR
>NZ_CP053564.1|WP_172169420.1|5962810_5963986_-|ROK-family-transcriptional-regulator
MGEHGSGSSGARPDEARRHNRAALLRRLHVDGPCTRAVLAAELGLNRSTIKAVVDGLAESGVVTEAVPARRTGAGRPSLMVLPQPESAVVLAVDVRVEQVAMSMVGLGGQVIGRHSWNLRRSTRTPGEVITHVAESAQLLAEELAVTPSGAGISVPGVVRRDDGWVHEAPNLEWRDIALGARLAAVLRLPVQVANDAEMGALAEHVRGVAREVADLVYISADKGVGGGVISSGRPLRGTRGYVGELGHLVVRPGGRPCYCGSRGCWETEVGEAALCRALGMPEDTPRGVVVAELRSLETAPVPGPLDEFAEWLATGLVTVVNMMAPELVVLGDLFTALPPGVVGHVRTLVHERSLVSRAVGGTRIETSPLGRDAKLVGAAELAFEPVLGAV
>NZ_CP053564.1|WP_172164672.1|5962316_5962634_+|hypothetical-protein
MRARVVLVVLSALLALGACTGTSRSSSCSGGVCSISLSGEQTVEVEIGSLERDLRVSAITPTAVTVSARGDSATLAPGGSAPVAGLLVRVDAIEGRDVELNVTRA
>NZ_CP053564.1|WP_172164669.1|5961100_5962102_-|ABC-transporter-substrate-binding-protein
MARALAVLLATLSLVLAACSGAPPGRTPIRVALDWTPNTNHTGLYVAQVEGWFAEAGLDVEFLPYNSTSPDTLVSAGAAEFGISFQDSFTYSKAAGADITSVMAVLQHWGSEIAVRADRADITSPADLDGSVYGGFGGPGEAPKMQAVIRGAGGVGEFETVVLGTSAYEALYSGDVDFTEPFVAWEGIEAELRGEPLKTFAYTDYGFPDAYSVLLIGNSPWLAGHPEEARAFVQAAQRGYQLGADDPARAAQLLMDANPGVFAEPELVTRSQDLLAAEYLRDESGAVGPQTLERWSGYSGFVVDSGSLTGPDGSPVTERPDFATWFTNEYLAP
>NZ_CP053564.1|WP_172169417.1|5960285_5961092_-|ABC-transporter-permease
MATTRLARSSTPTRGGVGLVWPALLLVALGLVAWQVGVDASGVRPQVLPSPLRVVEQGWAYRGPIWENTVPTLQATAVGFTVSLALAWTLAVAVDFSPWLRRALTPLLVASQTLPIIAIAPLLIIWLGFGLAPKVVVIALVTFFPMAVGLIEGFASTPRQATSLLRSMGASRWAQFRHVRLPGAMPSFFTALRIGITYAVTGAIFAEYVGATAGLGIFMSVQKNSFRTDLVLAAVVVTALLSVALFALTFLVQRLVAPWSRDGGSRDV
>NZ_CP053564.1|WP_172169428.1|5971276_5972950_-|DEAD/DEAH-box-helicase
MRAWQRKALSRYLAAGPQDFLAVATPGAGKTAFALRVASELLADRTISNITVVAPTEHLKYQWSQAAAAVGIALDPEFRNSAGGTSSDYTGIVVTYAGVAAHPLLHRARTESRRTLVVLDEVHHAGDARSWGDAVKEAFDPAARRLTLTGTPFRSDDNPIPFVDYLPDADGALRSRSDHSYGYAEALADGVVRPVVFLAYSGVSSWRTSAGEEITARLGEPLTAEQTARAWRTALDPGGEWIPAVLAAADKRLTGHRLGGMPDAGGLVIASDQTTARAYAAILTDVTGTPPVLVLSDEAGSSERIARFSASTDRWMVAVRMVSEGVDVPRLAVGVYATSASTPLFFAQAIGRFVRSRRPGETASVFVPSVPVLLGLASELEAQRDHVLGKPHRAEEQWNDEELAAANRQEDEPGEDEPSFTALGANAELDQLIYEGTSFSADEEDYLGLPGLLEPDQVRTLLNQRQTEWLSRSGRKAPAVVAPPVAEPAERPQQSVRERIAALRKELNTLVALHHHRTNKPHGKIHNELRTLCGGPPTAMANMEQLEERIATLRSWR
>NZ_CP053564.1|WP_172164687.1|5973114_5974152_+|YihY/virulence-factor-BrkB-family-protein
MSDAPTSSDPAPTWRRVVGRTLGGAWDKDIFSHSAQAAFWQALSLPPLFLALLGSLGYVGDWFGNDTVRVVEESIVTFARQVFTPEVVDEIIAPTASSILTNGRADVVSVGFVIALWAGSSAIASLVDSITEAHGQKLVRHPVWQRIFSLLVYLLALVVAIVTLPVIALGPDLLPQVLPASWRGAATSLIGAFYYPGAALITVLVLTAMYRLALPHTLPWRRLLPGALLAMVVFIASATGLRVYIAVLTSTGYTYGALATPIAFLLFGFLLGLSIVLGAHLNNAVEEAWPARPEPRPRRSDRLRAMRTHPAMPPVADEPGPDLPVTAPAAHAARTTASDSTKEPR
>NZ_CP053564.1|WP_172164690.1|5974148_5975849_+|alpha/beta-fold-hydrolase
MTAEQSADPDVATGLDMLLSDGALGPLRRILPGGAGLRMAAKLATKPVTLTRRGAGLAAELAKIGVGASALEPGPKDKRYADPAWTENPLLHRLVQTHIAAGGTAADLVEDAGLDWADHERIQFAVSNVVDALAPSNSLLNPALWQEARKTGGASIVSGVRRLVGDLATKPRVPSMVEPDAFTVGEDVACTPGAVVLRTPVFELIQYLPQTPTVREVPLLIVPPTINKYYVADLAPGRSIVENLLKSGQQVFLMSWRNPTEEHAAWDLDTYGSAILDAMTACEKISRQPSTALMAFCSGGIITSMLLGHLAATGAQERVASVTFAVTVLDQAQSGTTGALLDPDTARQAVEASQKKGYLDGRTLAEVFAWLRPNDLIWSYWVNNYLKGRPPKAFDILFWNADTTRMTAGLHRDFIDIAVANALVVPNATTMLGTPVDLSKVDRDMYVIAGIADHLCAWQSCFRTTQLLGGESRFVLSTSGHIASLVNPPGNPKASFRVAPPASRTPTPINADAWLAVAETVKGSWWPDHADWLGQRCGGEVDAPAELGGRGLPALVPAPGDYVRAT
>NZ_CP053564.1|WP_172169431.1|5975878_5976667_+|poly(3-hydroxyalkanoate)-depolymerase
MDVRGRCLRVSVRRAAGPGSRVPLLLMNGIGASLELLQPFVDELPPELEVIRFDVPGIGGSPMPRLPYHMSTFAPLIGTLVRRLGYGEVDVMGFSWGGGLAQQFAAAQRKQCRRLVLAATGTGSLMVPARPNVLAKMLTPRRHRDPEYARTIAGEIYGGTMRTHPERASEVLHTYTRKGPKRGYYYQLLAGAGWSSLPGLPLIRQPTLIVAGDDDPIIPVVNARIMHRGIPNSRLHIYSGGHLALLTEAKELAPVIDRFLTE
>NZ_CP053564.1|WP_172164693.1|5978009_5978633_-|methyltransferase-domain-containing-protein
MRGWLYDRAITGLTAGWYRAVFERLPDGARILDVGIGTGTALARGGETVRRKNLQITGLDIDRDYLCRCVEEMARAGLSEHVTPKLESVYDHRDGPYDAAYFSASLMLLPDPVAALRHVSGLLAPEGQLFFTQTFHHRRSPLREKVKPLMRHVTTIDFGTVTYEDEFRRVLAAADLQVVELVTLGTTRSSSYRLAVAVPDGGKRAAA
>NZ_CP053564.1|WP_172164696.1|5978658_5978907_-|DUF3039-domain-containing-protein
MATQVLPDVETRPEGTDSTGTDEPKMFHYVKKNRIAESAVLGNMVQALCGETFPVTRSPKPGSPVCPDCKKIFDGLRPGGDD
>NZ_CP053564.1|WP_172164699.1|5978905_5979844_+|pseudouridine-5'-phosphate-glycosidase
MSSMMPHVSRSVSFPALSRDVADALASGGAVVALESTILAHGLPAPQNRDAADELEEEVRAHGAVPATVAVLDGVPRVGLNAAELDRVCGGDLDKLSVRDLGVAVGLGRDGATTVAATAALAAAAGVPLFATGGLGGVHRGARDTWDVSADLAALARTGVLVVCSGVKSILDVAATLEVLETESVPVLGYGTDAFPGFYRRDSGHAVPWRVDSPAEAAAVWRAHRDLSPGVGAVLAQPVPVDDELDAALHDRLLTEGLALLAERGITGKDVTPALLEHFHAGSDGASLRTNLALVRANAGLAARVAVALAGG
>NZ_CP053564.1|WP_172164702.1|5979840_5980686_+|ribokinase
MTPVVVVGDLGVDVLVTPSTPPVPGADVPARIRTTAGGAGANTAAWLAHLGAPVTLVARVGDDGPGRAAVAELGASGVRVAAAVDPDAPTCTVVVLLDGDRTMLSDRGAAARLSPDDLPPLTGRGHLHLSGYVLLDPPSRPAGLAALAAARAAGWTTSVDPQAAPALTPEFLRWVRGVDLLLPNADELAALGGSARALLDVVGAVAVTDGGRGARWVDRSGTWSVVPRAVTPVDPTGAGDAFDAGLLAARLAGAGPEEALAAGCAAGAAAVRHPGARPLTP
>NZ_CP053564.1|WP_172164705.1|5980675_5981002_-|hypothetical-protein
MSLDWASVLDRYRGGRTVRPLVGSSTLRVEVDGDALVVTQRLWRAEVTRSELQVALDLLGDRGAQVGAVGFSEELRRHYSGGPQVQPTCSRTPNLSAVVLVDLGHLRV
>NZ_CP053564.1|WP_172164708.1|5980998_5981298_-|hypothetical-protein
MPLDWTRVMDRYDGGVRIPTVAGGKTLEITGVDDTGVHIRNSLWRDVLAREHLEKAAGLIESDRMSRHAGLFVEEYRALVADVRATSAAHVLKDLGYLE

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Crispr_ID: NZ_CP053564_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053564_10

6008198-6008294

Orphan

Consensus_repeat	Method
CGCGGACCATCAGCCCTTGATCG	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP053564_10

>merge|NZ_CP053564|10|6008198-6008294|CRISPRCasFinder
CGCTGACCCACCGGCCCTGATCGCCGAGACTGTCGCGTCAGGGTCGCGGCGGGGCCGCGAGGTCGCACTCCCGGCGCACACCATCAGCCCTTGATCG

>NZ_CP053564|10|7|6008198-6008294|CRISPRCasFinder
CGCTGACCCACCGGCCCTGATCG	CCGAGACTGTCGCGTCAGGGTCGCGGCGGGGCCGCGAGGTCGCACTCCCGG
CGCACACCATCAGCCCTTGATCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053564.1\|WP_172164792.1\|6007354_6007705_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053564.1\|WP_172169446.1\|6019371_6021144_+\|TerD-family-protein	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|180377
NZ_CP053564.1\|WP_172164801.1\|6010317_6011832_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|197715
NZ_CP053564.1\|WP_172169440.1\|6005559_6006519_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381324
NZ_CP053564.1\|WP_172169443.1\|6006684_6007155_-\|flavin-reductase-family-protein	unknown	unknown	gnl\|CDD\|214900
NZ_CP053564.1\|WP_172164810.1\|6012997_6015367_-\|FdhF/YdeP-family-oxidoreductase	unknown	unknown	gnl\|CDD\|273765
NZ_CP053564.1\|WP_172164816.1\|6016248_6017043_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235546
NZ_CP053564.1\|WP_172164813.1\|6015384_6016224_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP053564.1\|WP_172169437.1\|6004609_6005551_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|181169
NZ_CP053564.1\|WP_172164807.1\|6012534_6012987_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319940
NZ_CP053564.1\|WP_172164780.1\|5997966_5998392_+\|D-tyrosyl-tRNA(Tyr)-deacylase	unknown	unknown	gnl\|CDD\|235383
NZ_CP053564.1\|WP_172164789.1\|6003056_6003980_+\|DUF3141-domain-containing-protein	unknown	unknown	gnl\|CDD\|130895
NZ_CP053564.1\|WP_172164783.1\|5998518_5999973_+\|DUF222-domain-containing-protein	unknown	unknown	gnl\|CDD\|367155
NZ_CP053564.1\|WP_172164795.1\|6009226_6009769_-\|isopentenyl-diphosphate-Delta-isomerase	unknown	unknown	gnl\|CDD\|235156
NZ_CP053564.1\|WP_172153796.1\|6003889_6004312_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|225783
NZ_CP053564.1\|WP_172164798.1\|6009773_6010289_-\|DUF664-domain-containing-protein	unknown	unknown	gnl\|CDD\|368218
NZ_CP053564.1\|WP_172164819.1\|6017184_6018372_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379258
NZ_CP053564.1\|WP_172164786.1\|6000677_6001052_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP053564.1\|WP_172164804.1\|6011932_6012538_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053564.1\|WP_172169434.1\|6001076_6002840_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|213656

Protein	Function_ID	Function_description	E-value
NZ_CP053564.1\|WP_172164801.1\|6010317_6011832_-\|hypothetical-protein	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	2.83889e-16
NZ_CP053564.1\|WP_172169440.1\|6005559_6006519_+\|aldo/keto-reductase	gnl\|CDD\|381324	cd19098, AKR_unchar, uncharacterized aldo-keto reductase (AKR) superfamily protein. This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.	6.66949e-129
NZ_CP053564.1\|WP_172169443.1\|6006684_6007155_-\|flavin-reductase-family-protein	gnl\|CDD\|214900	smart00903, Flavin_Reduct, Flavin reductase like domain. This entry represents the FMN-binding domain found in NAD(P)H-flavin oxidoreductases (flavin reductases), a class of enzymes capable of producing reduced flavin for bacterial bioluminescence and other biological processes. This domain is also found in various other oxidoreductase and monooxygenase enzymes... This domain consists of a beta-barrel with Greek key topology, and is related to the ferredoxin reductase-like FAD-binding domain. The flavin reductases have a different dimerisation mode than that found in the PNP oxidase-like family, which also carries an FMN-binding domain with a similar topology.	4.04744e-56
NZ_CP053564.1\|WP_172164810.1\|6012997_6015367_-\|FdhF/YdeP-family-oxidoreductase	gnl\|CDD\|273765	TIGR01701, Hypothetical_protein_Rv2900c/MT2968/Mb2924c., oxidoreductase alpha (molybdopterin) subunit. This model represents a well-defined clade of oxidoreductase alpha subunits most closely related to a group of formate dehydrogenases including the E. coli FdhH protein (TIGR01591). These alpha subunits contain a molybdopterin cofactor and generally associate with two other subunits which contain iron-sulfur clusters and cytochromes. The particular subunits with which this enzyme interacts and the substrate which is reduced is unknown at this time. In Ralstonia, the gene is associated with the cbb operon, but is not essential for CO2 fixation.	0
NZ_CP053564.1\|WP_172164816.1\|6016248_6017043_-\|SDR-family-oxidoreductase	gnl\|CDD\|235546	PRK05653, fabG, 3-oxoacyl-ACP reductase FabG.	1.44803e-71
NZ_CP053564.1\|WP_172164813.1\|6015384_6016224_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.56036e-30
NZ_CP053564.1\|WP_172169437.1\|6004609_6005551_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|181169	PRK07921, PRK07921, RNA polymerase sigma factor SigB; Reviewed.	0
NZ_CP053564.1\|WP_172164807.1\|6012534_6012987_+\|VOC-family-protein	gnl\|CDD\|319940	cd08352, VOC_Bs_YwkD_like, vicinal oxygen chelate (VOC) family protein Bacillus subtilis YwkD and similar proteins. uncharacterized subfamily of vicinal oxygen chelate (VOC) family contains Bacillus subtilis YwkD and similar proteins. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	3.16589e-13
NZ_CP053564.1\|WP_172164780.1\|5997966_5998392_+\|D-tyrosyl-tRNA(Tyr)-deacylase	gnl\|CDD\|235383	PRK05273, PRK05273, D-tyrosyl-tRNA(Tyr) deacylase; Provisional.	2.8499e-76
NZ_CP053564.1\|WP_172164789.1\|6003056_6003980_+\|DUF3141-domain-containing-protein	gnl\|CDD\|130895	TIGR01836, Poly-beta-hydroxybutyrate_polymerase, poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit. This model represents the PhaC subunit of a heterodimeric form of polyhydroxyalkanoic acid (PHA) synthase. Excepting the PhaC of Bacillus megaterium (which needs PhaR), all members require PhaE (TIGR01834) for activity and are designated class III. This enzyme builds ester polymers for carbon and energy storage that accumulate in inclusions, and both this enzyme and the depolymerase associate with the inclusions. Class III enzymes polymerize short-chain-length hydroxyalkanoates. [Fatty acid and phospholipid metabolism, Biosynthesis].	3.97525e-12
NZ_CP053564.1\|WP_172164783.1\|5998518_5999973_+\|DUF222-domain-containing-protein	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	8.85234e-17
NZ_CP053564.1\|WP_172164795.1\|6009226_6009769_-\|isopentenyl-diphosphate-Delta-isomerase	gnl\|CDD\|235156	PRK03759, PRK03759, isopentenyl-diphosphate Delta-isomerase.	4.30474e-78
NZ_CP053564.1\|WP_172153796.1\|6003889_6004312_+\|alpha/beta-hydrolase	gnl\|CDD\|225783	COG3243, PhaC, Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism].	6.21474e-17
NZ_CP053564.1\|WP_172164798.1\|6009773_6010289_-\|DUF664-domain-containing-protein	gnl\|CDD\|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	3.83267e-12
NZ_CP053564.1\|WP_172164819.1\|6017184_6018372_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	4.31471e-19
NZ_CP053564.1\|WP_172164786.1\|6000677_6001052_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.30118e-11
NZ_CP053564.1\|WP_172169446.1\|6019371_6021144_+\|TerD-family-protein	gnl\|CDD\|180377	PRK06063, PRK06063, DEDDh family exonuclease.	2.55646e-106
NZ_CP053564.1\|WP_172169434.1\|6001076_6002840_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|213656	TIGR01838, Poly-beta-hydroxybutyrate_polymerase, poly(R)-hydroxyalkanoic acid synthase, class I. This model represents the class I subfamily of poly(R)-hydroxyalkanoate synthases, which polymerizes hydroxyacyl-CoAs with three to five carbons in the hydroxyacyl backbone into aliphatic esters termed poly(R)-hydroxyalkanoic acids. These polymers accumulate as carbon and energy storage inclusions in many species and can amount to 90 percent of the dry weight of cell. [Fatty acid and phospholipid metabolism, Biosynthesis].	0

>NZ_CP053564.1|WP_172164792.1|6007354_6007705_-|hypothetical-protein
MLKKAGILVAATAAGLLAVSPLAFAGDKGGWDGHGDSDGDRQVNRVDNDRDSAQTGLVNVGDVNALNDVNVCPAIPVAAGIGNILGILGAGGADADADGAAACVNDDSVNQANFED
>NZ_CP053564.1|WP_172169443.1|6006684_6007155_-|flavin-reductase-family-protein
MRDVLGHFVSGIVVITAAGPDGPLGFTCQSFSSLSLDPPLVSFAPARSSTTWPRIREVGAFCVNVLAADHQEISAGFARSGTDKFAGVAWRPGPSGAPLLEGVSAWVDCTLWGEHDGGDHTIAIGHVQDLGADPARMPLLFYRGRYGVTADPGDLG
>NZ_CP053564.1|WP_172169440.1|6005559_6006519_+|aldo/keto-reductase
MDTGTDRRETDRPGTDRLGIGLAAVARPAYITSGRATDLGDHRDVDALRARTHAVLDAAWAAGVRYVDVARSYGRAEEFVASWRAAHPDRAVRVGSKWGYRYVGEWRLDADVHEVKDHSLAAFTAQWAQTRAVLGVPAIYHVHSATLETGVLADAPLHGALAGLREQGVRVGVSTSGPAQADAVRRALEVVVDGEPLFTSVQSTWNVLEPSPGPALAEAHAAGALVIVKEPVANGRLAPVPDADPRAAALAQRAGVPLDRLAIAAALAQPWAGLVLSGAVDARQVASNVAALSVPGDVLDVPAEDPAAYWAARSARAWS
>NZ_CP053564.1|WP_172169437.1|6004609_6005551_+|sigma-70-family-RNA-polymerase-sigma-factor
MSAEDLDAQSPAADLVRVYLNGIGKTALLTAAQEVDLAKRIEAGVFAKHVLDSAETPLEKQYAADLRAIVRDGERARNHLLEANLRLVVSLAKRYTGRGMPLLDLIQEGNLGLIRAVEKFDYAKGFKFSTYATWWIRQAITRGMADQARTIRLPVHLVEQVNKLARIKRDLHQKLGRDATHEELAEESGIPEGKIADLLDHARDPVSLDMPVGSEEEAPLGDFIEDGEATDAETTVISHLLHDDLRRVLSTLEDREQHVIRMRYGLDDGQPRTLDQIGRRFGLSRERVRQIEREVMAKLRIGERADRLRAYAS
>NZ_CP053564.1|WP_172153796.1|6003889_6004312_+|alpha/beta-hydrolase
MFEDWFKHTQDIPGAFYLWLVEHLFHGNELISGDLVVDGRRADLANITCPLFLLAGSTDHITPPAQLFAAADAVGTPAAQVTRRTATGGHLGLFMGRDALRDDWPPLMEAVYALSAPGAPRRERAGAVADPGDTPRLPAP
>NZ_CP053564.1|WP_172164789.1|6003056_6003980_+|DUF3141-domain-containing-protein
MTAPTSTGIGDALRHLAAYNATAAARTTVELTRSAGNLWLDAVTRPRTPLANLARGALWWSTMADRREPRWHRDNTITLSTPFAHLRDFTAPADVDDDVVPTLVLPPQAGHSSHVIDFSPRQSQLAVLAAAGLTKLYALEWRAATTATRDVGVTDYLDLIDRSVRRMGGRANLVGDCQGGWLAAIYAALHPERVHTLTLAGAPIDFHAGESVIASSTRAMTGALGLAPTARWCAWAGATCPAVRCSPTSSRSSRSRRCRGSCSSWRTSTTPRTSSATACSRTGSSTPRTSPARSTCGSSSTCSTATS
>NZ_CP053564.1|WP_172169434.1|6001076_6002840_-|alpha/beta-fold-hydrolase
MDDEGVAVTRTSDPTSTLQRTASGVVDGVRDLLDPGALAARIDPVAFGGALGDVAKGLLSHPLPVARRTAGLAAGSGRAALAALARSVGGHGAGPAPLPDKDRRYADPAWEGNAYYYLLRQQHALFAEYLAAVAQGVELPPVSRRKIDFLVQQAVEATSPVNWPWSNPTMVKKAFETGGQSLFRGGRNLLRDVVGGGGMPRQTTPGEFEVGKDLAATPGVVVHRNRLMELIQYKPQTEQVHEIPLLLSPPWINKYYIMDLAPQKSLVEWAVQHGHTVFVISYRNPDESMRDVVMADYMQDGPLAALDVVQDITGSDKVNVAALCLGGTLAAATAAWLAARGDQRINSITLMNTLLDFSEPGRLGVFTDETTVNRLEHTMRRTGYLPASSMKTTFDLLRATDLVWNYVINDWLLGEEPAPFDMLAWNADSTRMPAAMQTEYLRNLYLDNQLVEGKMELAGERLDLGAVTQDAYVVSAEADHIAPWRSVYKGLRHLGGTVRFVLSNSGHIAGVVNPPSPKSKHWFGEGADLPESADDWRDDAGEHRASWWEDWSPWIGERAGEKTDPPRLGSDSYPVLQAAPGSYVLGT
>NZ_CP053564.1|WP_172164786.1|6000677_6001052_-|helix-turn-helix-transcriptional-regulator
MSAAEQPEPSGSWSINALGRFIRAQRQLAKLSLREMAAMTSVSNAYLSQVERGLHQPSLKVLHSIADALQLSTEQLLIQAGWRDAGPTPDPESTEDVIARDPRLTPAQRAALLSVYRSFVDDES
>NZ_CP053564.1|WP_172164783.1|5998518_5999973_+|DUF222-domain-containing-protein
MAPGPLLADALDEPASVVATGSETELLSLLALCEGVTRRVDAISTSAIATLDDQGAFLTRGYRSAARALSDLLSWDYVEARRRAAVAVDVHARTTLDGTPLPARLPSAAAAFAAGEIALRHVEVIGRILSTDAAGRLSPEQWAGVEAQPASDAARLNPSELQTLGTALVALLDQDGAEPDDHTPAPVNELRLTRHASGGSIKGRFEDPALYDAIAAVIDAKSAPLTADDDRPAPQRQAEALADICGYVLDHGDLPDTGGRRPLLTVIVRLEDLENRARSAMLEFGGSLTPAALRTLACDAGVIPVVMNGAGQPSTSAAPPAPSPTACAARSPPGTAAAPTPAATDPLLVGGPPHPPLGTRRTHRPAQPGDAVQGPPPPDPPHRLAGPHPGRPARVPAPEVDRPAPDTAPQSPRPPRSGLNPAQDHQEWCQAVIGDRLTPLLTIMTPARPEPRPTPPYPTPPCPTPPCPAPPGARPAPPPCPALP
>NZ_CP053564.1|WP_172164780.1|5997966_5998392_+|D-tyrosyl-tRNA(Tyr)-deacylase
MRAVAARVARASVTVDGAVVGSITGPGLLVLLGVHRDDTPAAVPVMARKLHELRILSGERSCAELGAPLLVVSQFTLYGDTRKGRRPSWSFAAPPGVAEPLVDAVVAALRERGAVVETGVFGAEMAVESVNDGPFTLLVES
>NZ_CP053564.1|WP_172164795.1|6009226_6009769_-|isopentenyl-diphosphate-Delta-isomerase
MPTPEQVVLVDDAGRPVGVAEKATVHGRRTPRHLAFSCYGFDAAGRVLVTRRARGKRAFPLVWTGTCCGHPAPGEDMADAVHRRLEHELGVRAHDLRLVLPDFSYRASDVNGVEEHEFCPVFVCSLDGDPDPRPDEVETWEWWGWERFLDAAAGGELSPWAALQAPLLADTVDPRTRRTG
>NZ_CP053564.1|WP_172164798.1|6009773_6010289_-|DUF664-domain-containing-protein
MNGIDVLADGFSRLRESAHAAVADLTPDQLTWRADPEANTVAWLLWHLARVQDDHVAGVAGSPQVWTRDGWAERFALPFDDGEIGYGQDAADVAAVRPGSADLLTGYLDAVLDRTGEHLRTLTDTDLDRVVDEDWDPPVTVGVRLVSVLNDDLQHVGQAALLRGIARRMAG
>NZ_CP053564.1|WP_172164801.1|6010317_6011832_-|hypothetical-protein
METRAADDRLAALLALAASHFREGRTGQAWEACAEAAGLARASGDAAALADAATVVRDVGPSPLAGRIHRLCVEALAALADREARGDADPVRRARVTAQLEATRSPWGRPSVPVETPDGDPDARFLALHAEHAQCRHVAHVERRLRIADEVVALGHASGSDEYTATGLAWRIEALGQSGRRWEQDAEVAALAAVVDGGRVPGWRPRLALTRACLLMADGRFADARALVAGESGFVALVVASHLAVLTGEGLDDVESEVRAAVDDLPYMARAWHAQVLAALGRLDEARELWRAIAPHVREVPRESPEWLIAGVGHAALAVLLGDAQTAAEVYDELAPWADLFVVAGADAPNEGPVALPLGRLAALLGRTAQARSHLTAALRAAERTHALPHVAQAHLELARLGGAGSGVHAEAAAALAARLGMAPLVAQVAALAPQRGPSRGPLSPRETEIAALVADGLANRAIAQRLTLSERTVENHVSHIMRKLDRPSRVAIAAWVRDSRGPL
>NZ_CP053564.1|WP_172164804.1|6011932_6012538_+|hypothetical-protein
MDTAPAVARRHPPTRTRTAGLVLLWGGIVGVVQAVVMLAVPAVVGPDRYSFPFTPGGYAIAQTTFALQHVALVVGVAVLAPMAATAVTRWALHGATAGLVLLTVMELVAITAAGSSVSDPQAELVNSLYGIPTILTGLGLLVGGFGLARGALRWVTVGLGAYVFVVLLPAIVAPYAAGRVAIGVWLLLFGVLGALLARGER
>NZ_CP053564.1|WP_172164807.1|6012534_6012987_+|VOC-family-protein
MTAPLPPFQGLSHLALSVVDVPAAIAFWVGVFGFEVLTDTPSLGLVVHRPTRVAIALTSNNGSTAGTFDERHPGLDHLAIAVPGVDDLHDWHARLTGLGVPCSPVTDSGSGHHLNLRAPDGVPVELYVIDAATVAALGLADAGEAFAGSR
>NZ_CP053564.1|WP_172164810.1|6012997_6015367_-|FdhF/YdeP-family-oxidoreductase
MDHAERRTTDYDESDLRVGEPEDWAAGATGVAVSMKRSLERMGPSRTARTLLKLNQAEGFDCMSCAWPDPDPGHRSVAEFCENGAKAVAEEATTDRATPDFFARHSIAELDARSEYWLGQQGRITHPMVKRPGDTHYRAIDWSDAFALIGDELRALDSPDEATFYTSGRASNEVAFAYQLFARAFGTNNLPDCSNMCHESTSIALQESIGIGKASVVMSDLETADLIVIAGQNPGTNHPRMLTHLEMAKDRGAKILTINPLREAGLTRFKNPQRPKGVVGPGTVLSDLHLPIRVNGDLALFQAMGALLVEWDALDHDFIDRHTTGFDAWKAHVADLDWADVVASTGLTREQITEAAQMLRDSGSTVFCWAMGITQHRNGVATIKEITNLALAQGGIGRPGAGLFPVRGHSNVQGDRTMGIWERVPDSFLDSVQEEFGFDPPREHGLDTVDSVRAMRDGKVRVFVGLGGNFAQATPDTDVTAAALRSTRLTVQISTKINRSHLVCGETALILPTLGRTEKDVQATGPQWISVEDSTCSVHSSRGPLPPASPHLRSEVAIITGIAEATIGDRHGIDWAAMRQDYRRIREHIARVVPGCESYEVNARRPGGFVLPHPPRDTRTFPTESGSAEFAVSPVEVLHVPDGHLLLQTLRSHDQFNTTIYGLSDRYRGIEGGRRVVFLHREDIAALGFDDGDHVDLTTRWDDDDVERCARDFRIVAYDTPRGTAAAYYPETNPLVPLDHTAEGSHQPASKSVIISLTRSAGPADGTGSQEGVSDDAGEKDHPQPMHLS
>NZ_CP053564.1|WP_172164813.1|6015384_6016224_-|alpha/beta-hydrolase
MPTFTTRDGVELAYEDTDPAGTGVPLVMLHGWGQTQAMFRHQLADLAPDRRVVTLDQRGHGRSAKPHHGYRIARLARDVQEFLDHLGVDEADVLGWSMGVSVWWSYLDQFGSGRIRRFVAVDQPAAVAAVPWMSTQEQQESGAIFDVAALVGLADSLAGEESEKATTAFVRGMFSGDTDPAVWDFVVSELGQIPPRAAVPLLFDHCAQDWRDVLPRIDVPTLVVGCDGSHVSPSSQRYIAEQVPGAQLYVFPVDEASSHFPFLENPARFNEVVSAFLDA
>NZ_CP053564.1|WP_172164816.1|6016248_6017043_-|SDR-family-oxidoreductase
MGRLDGRTALVFGGGHNAGGPPGTTGIGFATATTFAAHGARVVVVDRDAGAAERTVDAVREAGGRACAVVADATSPEQVEDAVARTVREHGGLDVVHNNVGVARLGGIEDLTLDEWRAAVTVNLDSVFLSARAALPHLARRRGCIVTVSSTASIRWTGYPYPGYAAAKAAVNQLTRSLAVEYAGRVRVNAILAGLIDTPLVYQQLAGADDPADVRARRDALSPTGAMGTAYDVAHAALFLASDEAAYVTGALLPVDGGLHARAV
>NZ_CP053564.1|WP_172164819.1|6017184_6018372_-|helix-turn-helix-domain-containing-protein
MTGWSGAADEVQVLVDELAEELGRSVVVNDPLVRPLCTSRHFGDADPVRIRAILQRDPGDEVRAHVLGHGVARWTAPATVPGAPALGLLPRLCAPLRVRGEYLGTLMVIDADGSVTDRERALVADAAGAVAALLAARAASAAAGRAGRERAVRALLGADPDARDAAVAELGTVLPARCVVVAVEVAGHGDPTDAALAEVALGEVVLRGTAGRGTGAVDGPRAVRVRPAADPDRLTADAAALRDAVCRALGPAARVAVGVGGAVDAGAAWQSARQAEVAVRAARRDPAGVAVWEGLRELATLLCLPDDLPPDAPAARALRALAAHDSGDRLRETLAAYLDHAGSAPRTAKALMLHRTSLYHRLRRIEEITGMDLSDGRDRLVLHLGLRLEALRPER
>NZ_CP053564.1|WP_172169446.1|6019371_6021144_+|TerD-family-protein
MDDLLDAGHTFAVVDVETTGLYPDRSRVLSVAAVGLDAAGRPDGPRFSSLVDPGCDPGPVHVHGLTRERLAGSPRFEEIAPRLLEVLDGRILVAHNAAFDHGFLAAESDRAGMKLPVDRRLCTLALSRRLGIDVPNHKLATLAEYWGVPQVGAHTADDDAHVLSRVLTHSLLLAANLGLPLPLIGCDDRTGTRYPPHVSSPPCPWAYPGRLAAGQPLVQGMKVAVTGSTGVPRLRLAARLTAAGLDVQNSVSRLTSVLVTNEPASTTRKAARARAEGIPVVDEETLLRLLDAVQPGSPVEPRALRRTGPARQVVRGPLHGRRVLVLGGTHAQAAAVRAEITGAGGAAAVNLTAGVTDVVLMAGGETDRRLPRVREAELPLHRGEVALGITLPAPCTVPDPGDYVGRHRSAAPGAGVPVLPRGAVLDLPAESVWTVNVAWRADALATGTDVDVVAFLVDADERVIADEDFVFYNAPVSEHGTVAVSTDGDSERSVRIDLDLVSAQHDRIVVAAALDGAATFGDLGAVTLSVDGDTATAATATLDAGTTERTMLLAEVYRRQGVWRVRAVGQGYDDGLAELAVRYGVVVDAG

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Crispr_ID: NZ_CP053564_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053564_11

6018967-6019072

Orphan

Consensus_repeat	Method
GTCGTCAGCAGGGCGCTCACGTCACA	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP053564_11

>merge|NZ_CP053564|11|6018967-6019072|CRISPRCasFinder
GTCGTCAGCAGGGCGCTCACGTCACATTCTCGGCGATCACCCCACCCACGGAGCCGGTGATCACCGAAAGCGCCGCCACCGTCGTCGGCAGGGCGCTCACGTCACA

>NZ_CP053564|11|8|6018967-6019072|CRISPRCasFinder
GTCGTCAGCAGGGCGCTCACGTCACA	TTCTCGGCGATCACCCCACCCACGGAGCCGGTGATCACCGAAAGCGCCGCCACC
GTCGTCGGCAGGGCGCTCACGTCACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053564.1\|WP_172164792.1\|6007354_6007705_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053564.1\|WP_172164834.1\|6024244_6024949_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380061
NZ_CP053564.1\|WP_172164819.1\|6017184_6018372_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379258
NZ_CP053564.1\|WP_172164843.1\|6027306_6028788_-\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|236203
NZ_CP053564.1\|WP_172164810.1\|6012997_6015367_-\|FdhF/YdeP-family-oxidoreductase	unknown	unknown	gnl\|CDD\|273765
NZ_CP053564.1\|WP_172164825.1\|6022070_6023315_-\|alpha/beta-hydrolase	unknown	unknown	unknown
NZ_CP053564.1\|WP_172164837.1\|6024977_6025721_-\|maleate-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|226004
NZ_CP053564.1\|WP_172164816.1\|6016248_6017043_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235546
NZ_CP053564.1\|WP_172164822.1\|6021151_6022012_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
NZ_CP053564.1\|WP_172164846.1\|6028905_6031029_+\|hydantoinase/oxoprolinase-family-protein	unknown	unknown	gnl\|CDD\|223223
NZ_CP053564.1\|WP_172164807.1\|6012534_6012987_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319940
NZ_CP053564.1\|WP_172164801.1\|6010317_6011832_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|197715
NZ_CP053564.1\|WP_172164804.1\|6011932_6012538_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053564.1\|WP_172164828.1\|6023311_6023560_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053564.1\|WP_172164831.1\|6023556_6024186_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|223423
NZ_CP053564.1\|WP_172164795.1\|6009226_6009769_-\|isopentenyl-diphosphate-Delta-isomerase	unknown	unknown	gnl\|CDD\|235156
NZ_CP053564.1\|WP_172164813.1\|6015384_6016224_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP053564.1\|WP_172164798.1\|6009773_6010289_-\|DUF664-domain-containing-protein	unknown	unknown	gnl\|CDD\|368218
NZ_CP053564.1\|WP_172164840.1\|6025717_6027310_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|223952
NZ_CP053564.1\|WP_172169446.1\|6019371_6021144_+\|TerD-family-protein	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|180377

Protein	Function_ID	Function_description	E-value
NZ_CP053564.1\|WP_172164834.1\|6024244_6024949_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|380061	pfam17932, TetR_C_24, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.	2.51305e-24
NZ_CP053564.1\|WP_172164819.1\|6017184_6018372_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	4.31471e-19
NZ_CP053564.1\|WP_172164843.1\|6027306_6028788_-\|FAD-dependent-monooxygenase	gnl\|CDD\|236203	PRK08255, PRK08255, bifunctional salicylyl-CoA 5-hydroxylase/oxidoreductase.	5.94633e-95
NZ_CP053564.1\|WP_172164810.1\|6012997_6015367_-\|FdhF/YdeP-family-oxidoreductase	gnl\|CDD\|273765	TIGR01701, Hypothetical_protein_Rv2900c/MT2968/Mb2924c., oxidoreductase alpha (molybdopterin) subunit. This model represents a well-defined clade of oxidoreductase alpha subunits most closely related to a group of formate dehydrogenases including the E. coli FdhH protein (TIGR01591). These alpha subunits contain a molybdopterin cofactor and generally associate with two other subunits which contain iron-sulfur clusters and cytochromes. The particular subunits with which this enzyme interacts and the substrate which is reduced is unknown at this time. In Ralstonia, the gene is associated with the cbb operon, but is not essential for CO2 fixation.	0
NZ_CP053564.1\|WP_172164837.1\|6024977_6025721_-\|maleate-cis-trans-isomerase	gnl\|CDD\|226004	COG3473, COG3473, Maleate cis-trans isomerase [Secondary metabolites biosynthesis, transport, and catabolism].	8.57707e-63
NZ_CP053564.1\|WP_172164816.1\|6016248_6017043_-\|SDR-family-oxidoreductase	gnl\|CDD\|235546	PRK05653, fabG, 3-oxoacyl-ACP reductase FabG.	1.44803e-71
NZ_CP053564.1\|WP_172164822.1\|6021151_6022012_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	1.20662e-31
NZ_CP053564.1\|WP_172164846.1\|6028905_6031029_+\|hydantoinase/oxoprolinase-family-protein	gnl\|CDD\|223223	COG0145, HyuA, N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	7.375e-159
NZ_CP053564.1\|WP_172164807.1\|6012534_6012987_+\|VOC-family-protein	gnl\|CDD\|319940	cd08352, VOC_Bs_YwkD_like, vicinal oxygen chelate (VOC) family protein Bacillus subtilis YwkD and similar proteins. uncharacterized subfamily of vicinal oxygen chelate (VOC) family contains Bacillus subtilis YwkD and similar proteins. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	3.16589e-13
NZ_CP053564.1\|WP_172164801.1\|6010317_6011832_-\|hypothetical-protein	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	2.83889e-16
NZ_CP053564.1\|WP_172164840.1\|6025717_6027310_-\|AMP-binding-protein	gnl\|CDD\|223952	COG1021, EntE, Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	2.02149e-142
NZ_CP053564.1\|WP_172164831.1\|6023556_6024186_-\|VOC-family-protein	gnl\|CDD\|223423	COG0346, GloA, Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism].	3.52345e-12
NZ_CP053564.1\|WP_172164795.1\|6009226_6009769_-\|isopentenyl-diphosphate-Delta-isomerase	gnl\|CDD\|235156	PRK03759, PRK03759, isopentenyl-diphosphate Delta-isomerase.	4.30474e-78
NZ_CP053564.1\|WP_172164813.1\|6015384_6016224_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.56036e-30
NZ_CP053564.1\|WP_172164798.1\|6009773_6010289_-\|DUF664-domain-containing-protein	gnl\|CDD\|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	3.83267e-12
NZ_CP053564.1\|WP_172169446.1\|6019371_6021144_+\|TerD-family-protein	gnl\|CDD\|180377	PRK06063, PRK06063, DEDDh family exonuclease.	2.55646e-106

>NZ_CP053564.1|WP_172164819.1|6017184_6018372_-|helix-turn-helix-domain-containing-protein
MTGWSGAADEVQVLVDELAEELGRSVVVNDPLVRPLCTSRHFGDADPVRIRAILQRDPGDEVRAHVLGHGVARWTAPATVPGAPALGLLPRLCAPLRVRGEYLGTLMVIDADGSVTDRERALVADAAGAVAALLAARAASAAAGRAGRERAVRALLGADPDARDAAVAELGTVLPARCVVVAVEVAGHGDPTDAALAEVALGEVVLRGTAGRGTGAVDGPRAVRVRPAADPDRLTADAAALRDAVCRALGPAARVAVGVGGAVDAGAAWQSARQAEVAVRAARRDPAGVAVWEGLRELATLLCLPDDLPPDAPAARALRALAAHDSGDRLRETLAAYLDHAGSAPRTAKALMLHRTSLYHRLRRIEEITGMDLSDGRDRLVLHLGLRLEALRPER
>NZ_CP053564.1|WP_172164816.1|6016248_6017043_-|SDR-family-oxidoreductase
MGRLDGRTALVFGGGHNAGGPPGTTGIGFATATTFAAHGARVVVVDRDAGAAERTVDAVREAGGRACAVVADATSPEQVEDAVARTVREHGGLDVVHNNVGVARLGGIEDLTLDEWRAAVTVNLDSVFLSARAALPHLARRRGCIVTVSSTASIRWTGYPYPGYAAAKAAVNQLTRSLAVEYAGRVRVNAILAGLIDTPLVYQQLAGADDPADVRARRDALSPTGAMGTAYDVAHAALFLASDEAAYVTGALLPVDGGLHARAV
>NZ_CP053564.1|WP_172164813.1|6015384_6016224_-|alpha/beta-hydrolase
MPTFTTRDGVELAYEDTDPAGTGVPLVMLHGWGQTQAMFRHQLADLAPDRRVVTLDQRGHGRSAKPHHGYRIARLARDVQEFLDHLGVDEADVLGWSMGVSVWWSYLDQFGSGRIRRFVAVDQPAAVAAVPWMSTQEQQESGAIFDVAALVGLADSLAGEESEKATTAFVRGMFSGDTDPAVWDFVVSELGQIPPRAAVPLLFDHCAQDWRDVLPRIDVPTLVVGCDGSHVSPSSQRYIAEQVPGAQLYVFPVDEASSHFPFLENPARFNEVVSAFLDA
>NZ_CP053564.1|WP_172164810.1|6012997_6015367_-|FdhF/YdeP-family-oxidoreductase
MDHAERRTTDYDESDLRVGEPEDWAAGATGVAVSMKRSLERMGPSRTARTLLKLNQAEGFDCMSCAWPDPDPGHRSVAEFCENGAKAVAEEATTDRATPDFFARHSIAELDARSEYWLGQQGRITHPMVKRPGDTHYRAIDWSDAFALIGDELRALDSPDEATFYTSGRASNEVAFAYQLFARAFGTNNLPDCSNMCHESTSIALQESIGIGKASVVMSDLETADLIVIAGQNPGTNHPRMLTHLEMAKDRGAKILTINPLREAGLTRFKNPQRPKGVVGPGTVLSDLHLPIRVNGDLALFQAMGALLVEWDALDHDFIDRHTTGFDAWKAHVADLDWADVVASTGLTREQITEAAQMLRDSGSTVFCWAMGITQHRNGVATIKEITNLALAQGGIGRPGAGLFPVRGHSNVQGDRTMGIWERVPDSFLDSVQEEFGFDPPREHGLDTVDSVRAMRDGKVRVFVGLGGNFAQATPDTDVTAAALRSTRLTVQISTKINRSHLVCGETALILPTLGRTEKDVQATGPQWISVEDSTCSVHSSRGPLPPASPHLRSEVAIITGIAEATIGDRHGIDWAAMRQDYRRIREHIARVVPGCESYEVNARRPGGFVLPHPPRDTRTFPTESGSAEFAVSPVEVLHVPDGHLLLQTLRSHDQFNTTIYGLSDRYRGIEGGRRVVFLHREDIAALGFDDGDHVDLTTRWDDDDVERCARDFRIVAYDTPRGTAAAYYPETNPLVPLDHTAEGSHQPASKSVIISLTRSAGPADGTGSQEGVSDDAGEKDHPQPMHLS
>NZ_CP053564.1|WP_172164807.1|6012534_6012987_+|VOC-family-protein
MTAPLPPFQGLSHLALSVVDVPAAIAFWVGVFGFEVLTDTPSLGLVVHRPTRVAIALTSNNGSTAGTFDERHPGLDHLAIAVPGVDDLHDWHARLTGLGVPCSPVTDSGSGHHLNLRAPDGVPVELYVIDAATVAALGLADAGEAFAGSR
>NZ_CP053564.1|WP_172164804.1|6011932_6012538_+|hypothetical-protein
MDTAPAVARRHPPTRTRTAGLVLLWGGIVGVVQAVVMLAVPAVVGPDRYSFPFTPGGYAIAQTTFALQHVALVVGVAVLAPMAATAVTRWALHGATAGLVLLTVMELVAITAAGSSVSDPQAELVNSLYGIPTILTGLGLLVGGFGLARGALRWVTVGLGAYVFVVLLPAIVAPYAAGRVAIGVWLLLFGVLGALLARGER
>NZ_CP053564.1|WP_172164801.1|6010317_6011832_-|hypothetical-protein
METRAADDRLAALLALAASHFREGRTGQAWEACAEAAGLARASGDAAALADAATVVRDVGPSPLAGRIHRLCVEALAALADREARGDADPVRRARVTAQLEATRSPWGRPSVPVETPDGDPDARFLALHAEHAQCRHVAHVERRLRIADEVVALGHASGSDEYTATGLAWRIEALGQSGRRWEQDAEVAALAAVVDGGRVPGWRPRLALTRACLLMADGRFADARALVAGESGFVALVVASHLAVLTGEGLDDVESEVRAAVDDLPYMARAWHAQVLAALGRLDEARELWRAIAPHVREVPRESPEWLIAGVGHAALAVLLGDAQTAAEVYDELAPWADLFVVAGADAPNEGPVALPLGRLAALLGRTAQARSHLTAALRAAERTHALPHVAQAHLELARLGGAGSGVHAEAAAALAARLGMAPLVAQVAALAPQRGPSRGPLSPRETEIAALVADGLANRAIAQRLTLSERTVENHVSHIMRKLDRPSRVAIAAWVRDSRGPL
>NZ_CP053564.1|WP_172164798.1|6009773_6010289_-|DUF664-domain-containing-protein
MNGIDVLADGFSRLRESAHAAVADLTPDQLTWRADPEANTVAWLLWHLARVQDDHVAGVAGSPQVWTRDGWAERFALPFDDGEIGYGQDAADVAAVRPGSADLLTGYLDAVLDRTGEHLRTLTDTDLDRVVDEDWDPPVTVGVRLVSVLNDDLQHVGQAALLRGIARRMAG
>NZ_CP053564.1|WP_172164795.1|6009226_6009769_-|isopentenyl-diphosphate-Delta-isomerase
MPTPEQVVLVDDAGRPVGVAEKATVHGRRTPRHLAFSCYGFDAAGRVLVTRRARGKRAFPLVWTGTCCGHPAPGEDMADAVHRRLEHELGVRAHDLRLVLPDFSYRASDVNGVEEHEFCPVFVCSLDGDPDPRPDEVETWEWWGWERFLDAAAGGELSPWAALQAPLLADTVDPRTRRTG
>NZ_CP053564.1|WP_172164792.1|6007354_6007705_-|hypothetical-protein
MLKKAGILVAATAAGLLAVSPLAFAGDKGGWDGHGDSDGDRQVNRVDNDRDSAQTGLVNVGDVNALNDVNVCPAIPVAAGIGNILGILGAGGADADADGAAACVNDDSVNQANFED
>NZ_CP053564.1|WP_172169446.1|6019371_6021144_+|TerD-family-protein
MDDLLDAGHTFAVVDVETTGLYPDRSRVLSVAAVGLDAAGRPDGPRFSSLVDPGCDPGPVHVHGLTRERLAGSPRFEEIAPRLLEVLDGRILVAHNAAFDHGFLAAESDRAGMKLPVDRRLCTLALSRRLGIDVPNHKLATLAEYWGVPQVGAHTADDDAHVLSRVLTHSLLLAANLGLPLPLIGCDDRTGTRYPPHVSSPPCPWAYPGRLAAGQPLVQGMKVAVTGSTGVPRLRLAARLTAAGLDVQNSVSRLTSVLVTNEPASTTRKAARARAEGIPVVDEETLLRLLDAVQPGSPVEPRALRRTGPARQVVRGPLHGRRVLVLGGTHAQAAAVRAEITGAGGAAAVNLTAGVTDVVLMAGGETDRRLPRVREAELPLHRGEVALGITLPAPCTVPDPGDYVGRHRSAAPGAGVPVLPRGAVLDLPAESVWTVNVAWRADALATGTDVDVVAFLVDADERVIADEDFVFYNAPVSEHGTVAVSTDGDSERSVRIDLDLVSAQHDRIVVAAALDGAATFGDLGAVTLSVDGDTATAATATLDAGTTERTMLLAEVYRRQGVWRVRAVGQGYDDGLAELAVRYGVVVDAG
>NZ_CP053564.1|WP_172164822.1|6021151_6022012_-|ABC-transporter-substrate-binding-protein
MLAGAGLLTVGCAAPPAPAPAAVRRVRDDLGRDVDVPADPQRVVVLDPNHLPPLLGEAASRIEAVGPLGQVSVESIVGLEPDLILFAADYQDDLDPEVLQRIVPTVAYSLRPSVQDHLRFVASVLGREGAAEDLISGFDAVLAARRAELGLADRPVAGVGMENSEAVATVDVTGPDSVFGELLTGLGVRLVPATVDGAPVEGLLEDLSAENLGTLLGEAETLIVSRRFGGDELERGFAATVDSPVWTRLPAVAAGRVAYVDNQLVYGSFGLRGFEVLLDDIAAQLG
>NZ_CP053564.1|WP_172164825.1|6022070_6023315_-|alpha/beta-hydrolase
MTTTERLGAGRYLDAGARPDATATSVHELTTADGATVRGVLATVPGATTVVCLTHPRQDLTHHPLVPVLLQAGVAVWTQHTRSVNNDLALVHEQALLDVAAGLSLMRERFASVVTLGHSGGGPLYAFYLEQAGLAPADRIATTPGGRPTGLADAVLPAVDGAVFLAPHPGQGRLLLGCIDPSVADESDPLSVVPDLDPYDPANGFAEPPHSSSYDAAFLERYRAAQRDRVARIDAVARLHLARAAEARAAAKRTGSAADRRRALAPRIMVVPRTDADPRTVDLSIDPSERPYGSLFGRRPDLINYGQVGFGRVTTPEAWLSTWSGLSSHADFVRCAPGVTAPTLFLELTGDQAAFPADSRRMVDALGAADLTHRTVRGLHFGAAIAEGEPTGNALAGEEIAAWLGERFATVPPG
>NZ_CP053564.1|WP_172164828.1|6023311_6023560_-|hypothetical-protein
MTVLYVLDVPENTPLAKVAAQDPTVTVDRIGPYFAIAADGPIVIDRRATGCRHAVWYSSVAGVERGSRITQHDKDALRVEPA
>NZ_CP053564.1|WP_172164831.1|6023556_6024186_-|VOC-family-protein
MTELDHRVQGVDHTAFPTFDPAGTVRFYRDVLGFPVVHSICAAGWGPEDHPDFIHFFFDIGNDDRIAFFYYFGLAPVHEHARGDVYAGFGPDVPEFFVRSRHLAIHVADEDDLLEYRRRLDDSDWPVEMQIKHETIESIYTHDPNGYMVEFTRAMRPVTPQEDLDANLTIDALLDVVDEGEPTFGKLLARKAELIVERAAAWELTRTPR
>NZ_CP053564.1|WP_172164834.1|6024244_6024949_-|TetR/AcrR-family-transcriptional-regulator
MSGPAERRNGRGASRRELVENEMYDHAVRLFAERGFAGTSLQDIADAMGVTRPALYYYVKSKDELLAKLAADVAGGSASEMAEIAARTDLDALGKLHAIARLTVVRLARQPDRFRLLIRSEAELPPELAASYVASRRAVLKAVADVVEQGVVAGQLRPVDARVGALAVIGMCNWVAWWFRPDRDDVDAVADQIADMALAALQRADHRTPEGEGPAAAIAMLRQDLDHLARVLDV
>NZ_CP053564.1|WP_172164837.1|6024977_6025721_-|maleate-cis-trans-isomerase
MTPLHRIGLVVPSSNVTVETEVPALLARHAGARFSFHSSRMRMHTVSPEELRAMNDQRGRCVDELADAGVDALLYACLVALMAQGPGEHRRAEEAVTAQLAAAGQAPAVLSSAGALVSGLHALGARRIGLVTPYLLPLAKQVVEYLESEGFTVRSFAALEVGDNAEVGCIPGDRVLDAARGLDLVGADALVISACVQMPSLDLVAPAEAEFGLPVLSAATAGAHALLRALELPAVLPGAGALLAAGG
>NZ_CP053564.1|WP_172164840.1|6025717_6027310_-|AMP-binding-protein
MSVPYPPEFVRRYRDAGLWGDRTIADELHAVARAHADRLAVVAAEGRLTFDELDAASDRLAAGLAARGLAPGDPVLFQVTNRLATVVAWYGVLKAGLVPVCTLAAHRGHEIGDISRRVGAVAHLVEAGTRGFDLVAFAHEQAAGHPTLRHVLVLDELHALGAGLDRAAARAVVEEVQRGIDPDDVAVFQLSGGTTGVPKVIPRRHAEYWYNAAEYARSWGWTPDTRVAHLIPVIHNAGIVCAVHGPHSAGAALVLGTADLDASLPLLADAGATHVLLGHGHFGAPDHPGFDAVARTLTQVVLSGSKVPPALFDAIERRGLWSGQLFGMGEGLFLTTRPGAAREARATTVGIPLSPHDEIRVLEPGTEDEVADGEVGELCCRGPYTLRGYLDAPEHNARAFTSDGFYRTGDLAAVRTIDGERCVSIEGRIKDLINRGGEKISAEEVELLLLRHPRVRGAAVVAVPDPRLGERSCAFLVVDGEPLGLPEVQRHFAGLQVAKFKWPERVELLTEIPRTLVGKVDKKRLTEGLR
>NZ_CP053564.1|WP_172164843.1|6027306_6028788_-|FAD-dependent-monooxygenase
MQPRRVAVLGGGPGGLYAARLLKLAQPACEVVVHEQGDRETTFGFGVGLAAGTQRKLEAADADTLRDIRAAGRRHDMTMEVGGAVARVRNDHLIGIARTELLDVLQRHAEKAGVQLEYGSRRTADDLDADVVVAADGVGSATREAGEFGTRVETGRGLYLWCGAAFALDDAVFAAVDTGHGTFVTHAYPYAPDRSTFLVETDEATWRAAGFETPDLDADGTDARSLDHLAAVFAGHLRGHALIGNRTRWTRFRTVRCDRWSDGRVVLLGDAAHTAHFSIGSGTKLAMEDAIALVAALGEEEAAAAAFARYEAERRPAVERLQELARRSRLWWESFPSRTHLPVERLMVSYMTRAGNVPLDRFAATSPDVVGAALGQYAGVAPVVPGDVTGWVLEQAAPAPGGLDVAETVVDAVVDDPWGPEADAVVAGSAGAAAVRVVGPPDRSALLTRLDLAERLRLEAGAVVTVEGPPELRDDLAAGLVSGRADRVALVAS
>NZ_CP053564.1|WP_172164846.1|6028905_6031029_+|hydantoinase/oxoprolinase-family-protein
MTYVIGVDVGGTFTDAVLDDDSGTVVAAKSPSTPPDYSRGVLDVLGLLAEQIGRTLPEMLADTHHIAHGTTSSLNALVMGNVPPVGFLTTKGHRDSIFIMNVEGRYLGRSPHELQHVLEQDKGHHLLPKRHALEVTERIDRDGTVIVALDEDGARAAIRALLDDGVRAIAISLLWSFRNPAHEQRLRELVAEQDPDVFVALSSEVSPRIREFSRNATTIMSTQIGPGLRDYLTTLEDALRAQGLAGPLLVMQSNGGAVAAAQAPAAAISTVGSVLTGGVVGSVQLGRQLGHRNIISTDVGGTTFLAGLVVDGEPVRDTTTIINHHPVNVPTLRVDAIGSGGGAIAWLDAGGNLRIGPRSAQAVPGPACYGQGGTEPTNTDANLVLGILTERGLLGGRKPLSLELARQAIDTQIAKPLGLSVEEAAAAIHAIQNAQTGDLLRKSVVEAGHDPRGFVLYAFGGAGPAHCARYAAEVGVEEVVVPLGPVASAFSAFGLAASDIVLAAELSDPTVVPFDPQRAERNFAELEQRVRDGLDRQGVSFSAVELHREIDMRYTMQLAEVTAPVPGGPLDTAAVEAAAAAFEERYAALYGAEAGFREAGIQAITFRVRGVGRLPFSPELPATGVADSPDPSDAVVGSRPVCLDAATGYVDTTIYDYRRLRAGHVLTGPAIVEVPTTTVVVPGGTTGTVDRLGNLTLRPTSTVGSPS

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Crispr_ID: NZ_CP053564_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053564_12

6164803-6165237

Orphan

Consensus_repeat	Method
GTGAGCAAGGACTGGAACTGA	CRT

7 spacers

The CRISPR arrays of NZ_CP053564_12

>merge|NZ_CP053564|12|6164803-6165237|CRT
ATGAGCAAGGACTGGAACTGAACGGCGACCCCCGGACGCGACGACGAGAGGAGCACGCCGTGAGCAAGGACTGGAACTGAGAACCGCCCGCCCCGCCCCCACGCCCCGGAGGGAGCCACCGGTGAGCAAGGACTGGAACTGACCGTCCCCACCACCCGCCCGCACCAGAGGAAGGAGCGCTACGTGAGCAAGGACTGGAACTGATCACCCCGACCGCCGCCCGCACCCACGAGAGGAGCAGCCAGTGAGCAAGGACTGGAACTGACGACCCGCACCCCGCCCCGACCAGAGGAAGGACGAGCCAGTGAGCAAGGACTGGAACTGATCACCCCGACCCCCGCCCGCACCCACGAGAGGAGCACGTCGTGAGCAAGGACTGGAACTGACCGCAAGCACCCCGACGAGAGGAACGCCGTGAGCAAGGACGGGAACTGA

>NZ_CP053564|12|3|6164803-6165237|CRT
ATGAGCAAGGACTGGAACTGA	ACGGCGACCCCCGGACGCGACGACGAGAGGAGCACGCC
GTGAGCAAGGACTGGAACTGA	GAACCGCCCGCCCCGCCCCCACGCCCCGGAGGGAGCCACCG
GTGAGCAAGGACTGGAACTGA	CCGTCCCCACCACCCGCCCGCACCAGAGGAAGGAGCGCTAC
GTGAGCAAGGACTGGAACTGA	TCACCCCGACCGCCGCCCGCACCCACGAGAGGAGCAGCCA
GTGAGCAAGGACTGGAACTGA	CGACCCGCACCCCGCCCCGACCAGAGGAAGGACGAGCCA
GTGAGCAAGGACTGGAACTGA	TCACCCCGACCCCCGCCCGCACCCACGAGAGGAGCACGTC
GTGAGCAAGGACTGGAACTGA	CCGCAAGCACCCCGACGAGAGGAACGCC
GTGAGCAAGGACGGGAACTGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053564.1\|WP_075949948.1\|6155997_6156651_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP053564.1\|WP_172165251.1\|6167152_6167593_-\|HIT-family-protein	unknown	unknown	gnl\|CDD\|223611
NZ_CP053564.1\|WP_172165263.1\|6174057_6176373_+\|malto-oligosyltrehalose-synthase	unknown	unknown	gnl\|CDD\|200475
NZ_CP053564.1\|WP_172169491.1\|6168162_6170331_+\|glycogen-debranching-protein-GlgX	unknown	unknown	gnl\|CDD\|131155
NZ_CP053564.1\|WP_172165248.1\|6166529_6167150_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_CP053564.1\|WP_172165257.1\|6170344_6171949_-\|thiamine-pyrophosphate-binding-protein	unknown	unknown	gnl\|CDD\|235931
NZ_CP053564.1\|WP_172165266.1\|6176374_6177223_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053564.1\|WP_172169494.1\|6173232_6173949_-\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_CP053564.1\|WP_172165239.1\|6161663_6162965_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NZ_CP053564.1\|WP_172165245.1\|6165241_6166468_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP053564.1\|WP_172165233.1\|6159043_6159709_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP053564.1\|WP_172165236.1\|6159708_6161628_-\|1-deoxy-D-xylulose-5-phosphate-synthase	unknown	unknown	gnl\|CDD\|235470
NZ_CP053564.1\|WP_172169488.1\|6156647_6157913_+\|ribonuclease-D	unknown	unknown	gnl\|CDD\|223426
NZ_CP053564.1\|WP_172165254.1\|6167634_6168096_+\|PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274679
NZ_CP053564.1\|WP_172165242.1\|6163046_6164405_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NZ_CP053564.1\|WP_172165221.1\|6152489_6153884_-\|protoporphyrinogen-oxidase	unknown	unknown	gnl\|CDD\|237009
NZ_CP053564.1\|WP_172165224.1\|6153880_6154966_-\|uroporphyrinogen-decarboxylase	unknown	unknown	gnl\|CDD\|234644
NZ_CP053564.1\|WP_172165260.1\|6171945_6173181_-\|aromatic-acid/H+-symport-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340923
NZ_CP053564.1\|WP_172165230.1\|6157934_6159044_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP053564.1\|WP_172165227.1\|6154964_6155702_+\|DUF3000-domain-containing-protein	unknown	unknown	gnl\|CDD\|378665

Protein	Function_ID	Function_description	E-value
NZ_CP053564.1\|WP_075949948.1\|6155997_6156651_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.98355e-54
NZ_CP053564.1\|WP_172165251.1\|6167152_6167593_-\|HIT-family-protein	gnl\|CDD\|223611	COG0537, Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only].	4.97253e-31
NZ_CP053564.1\|WP_172165263.1\|6174057_6176373_+\|malto-oligosyltrehalose-synthase	gnl\|CDD\|200475	cd11336, AmyAc_MTSase, Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase). Maltooligosyl trehalose synthase (MTSase) domain. MTSase and maltooligosyl trehalose trehalohydrolase (MTHase) work together to produce trehalose. MTSase is responsible for converting the alpha-1,4-glucosidic linkage to an alpha,alpha-1,1-glucosidic linkage at the reducing end of the maltooligosaccharide through an intramolecular transglucosylation reaction, while MTHase hydrolyzes the penultimate alpha-1,4 linkage of the reducing end, resulting in the release of trehalose. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NZ_CP053564.1\|WP_172169491.1\|6168162_6170331_+\|glycogen-debranching-protein-GlgX	gnl\|CDD\|131155	TIGR02100, Glycogen_operon_protein_GlgX_homolog, glycogen debranching enzyme GlgX. This family consists of the GlgX protein from the E. coli glycogen operon and probable equivalogs from other prokaryotic species. GlgX is not required for glycogen biosynthesis, but instead acts as a debranching enzyme for glycogen catabolism. This model distinguishes GlgX from pullanases and other related proteins that also operate on alpha-1,6-glycosidic linkages. In the wide band between the trusted and noise cutoffs are functionally similar enzymes, mostly from plants, that act similarly but usually are termed isoamylase. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NZ_CP053564.1\|WP_172165248.1\|6166529_6167150_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	5.16381e-38
NZ_CP053564.1\|WP_172165257.1\|6170344_6171949_-\|thiamine-pyrophosphate-binding-protein	gnl\|CDD\|235931	PRK07092, PRK07092, benzoylformate decarboxylase; Reviewed.	1.88784e-141
NZ_CP053564.1\|WP_172169494.1\|6173232_6173949_-\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	1.89677e-56
NZ_CP053564.1\|WP_172165239.1\|6161663_6162965_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.23159e-53
NZ_CP053564.1\|WP_172165245.1\|6165241_6166468_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.63996e-44
NZ_CP053564.1\|WP_172165233.1\|6159043_6159709_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.0739e-73
NZ_CP053564.1\|WP_172165236.1\|6159708_6161628_-\|1-deoxy-D-xylulose-5-phosphate-synthase	gnl\|CDD\|235470	PRK05444, PRK05444, 1-deoxy-D-xylulose-5-phosphate synthase; Provisional.	0
NZ_CP053564.1\|WP_172169488.1\|6156647_6157913_+\|ribonuclease-D	gnl\|CDD\|223426	COG0349, Rnd, Ribonuclease D [Translation, ribosomal structure and biogenesis].	1.67278e-83
NZ_CP053564.1\|WP_172165254.1\|6167634_6168096_+\|PPOX-class-F420-dependent-oxidoreductase	gnl\|CDD\|274679	TIGR03618, Rv1155_F420, PPOX class probable F420-dependent enzyme. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity].	8.89392e-30
NZ_CP053564.1\|WP_172165242.1\|6163046_6164405_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	7.44701e-58
NZ_CP053564.1\|WP_172165221.1\|6152489_6153884_-\|protoporphyrinogen-oxidase	gnl\|CDD\|237009	PRK11883, PRK11883, protoporphyrinogen oxidase; Reviewed.	1.89904e-145
NZ_CP053564.1\|WP_172165224.1\|6153880_6154966_-\|uroporphyrinogen-decarboxylase	gnl\|CDD\|234644	PRK00115, hemE, uroporphyrinogen decarboxylase; Validated.	0
NZ_CP053564.1\|WP_172165260.1\|6171945_6173181_-\|aromatic-acid/H+-symport-family-MFS-transporter	gnl\|CDD\|340923	cd17365, MFS_PcaK_like, 4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily. This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.12217e-93
NZ_CP053564.1\|WP_172165230.1\|6157934_6159044_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.51872e-46
NZ_CP053564.1\|WP_172165227.1\|6154964_6155702_+\|DUF3000-domain-containing-protein	gnl\|CDD\|378665	pfam11452, DUF3000, Protein of unknown function (DUF3000). This is a bacterial family of uncharacterized proteins.	9.08041e-82

>NZ_CP053564.1|WP_172165242.1|6163046_6164405_-|GGDEF-domain-containing-protein
MSPGRSTAGAGPGSGLPGFVAGWAIWNLPARLMAAVLTVEITAVALVLVLAVGEPGPDSRTIRDVVLLVVFGLLHTEIAHGVERVRRRVNGEVHVNLSSVWFFAATVLLPPVWAALVAVVVHLHLWLRSARPRNPLFKHVFSSATVVLSCMSASGVMSAVAADGTGDRGDVYVLALGVLVFLTVNTALVAGVIAVNSPQTDVASIVGEWDENLLEIATLCLGALAAAAIAINPWLVAFIFPPLLVLHRAVLVRQLEVAANTDGKTGLLNAAAWHTQAERELRRAERRSGPRAVLVIDLDHFKAVNDTHGHLAGDRVLAAVADALNAEVRDRDLVGRFGGEEFVVLLGALGEPGTGGGELQTVAERIRSRIAALRVEMPTADGPLTVAGLSASVGCALYPDDGRELRDLLQVADTALYAAKRAGRNVVRMGIQPPAPQPLLAEDSPQGRRYGQ
>NZ_CP053564.1|WP_172165239.1|6161663_6162965_-|GGDEF-domain-containing-protein
MDEPSPAPGSRTLWGLGPGPLGLALVVELTAVAVAVAGLVALPAAGQPLLLALGLTALSVVHTELATGIERVRRRASENSYFDLSSVWTFAAALLLPPGLAAVVIVLVYVHLWHRVWAPAGIPLYRHVFTTATVLLAARAAHEVVALAGGLPADPTQPGVVLAVGLAVGSYVLVNTLLVGAVIALSGPRPVLRDLFGRWDDNALEVATLCMGALAAVALASTPALVALVLPPILVLHRAVLVRQLEQEASTDAKTGLLNAAAWQTQALRVVDRARRTGSGAGVLMLDLDHFKIVNDTHGHLAGDDVLAAVAAELRAEVRSHDVVGRFGGEEFVVLLPDLPAGGTGRTELWRVAERLRDRVSRLDVGVATSGGLRTVTGLSVSIGGATVPTDGTTLDQVLTAADASLYEAKAGGRNLVRIAADAHVPSPRRPTA
>NZ_CP053564.1|WP_172165236.1|6159708_6161628_-|1-deoxy-D-xylulose-5-phosphate-synthase
MTVLRSISGPADLRRLGPDRLPELAAEIRRFLVECVSRTGGHLGPNLGVVELTIALHRVFDSPTDTVVWDTGHQAYVHKLLTGRHDGWDRLKKTGGLSGYPSRAESEHDVVESSHASSSLSWADGIARAYALTGQQRHVVAVIGDGALTGGMAWEALNNIATGDRNVVIVVNDNGRSYSPTIGGLADRLASLRLQPAYERVLDAGKAALSRTPVVGGTLYAGLHAVKAGLKDALSPQELFSDLGIKYFGPVDGHDVEAMESALHRAKRFGGPVIVHAVTRKGHGYLPAENDELEQMHSPAAFDPETGLPTGAPSVGWTSVFAEELVDIGRRRTDVVAITAAMLGPTGLAPFAAAYPDRWIDVGIAEQHALTCAAGLATGGMHPVVALYSTFLNRGFDQLLMDVALHGQAVTLVLDRAGVTGSDGPSHNGMWDLSLLGVVPGMRVAAPRDAVTLREELAEAIAVDDGPTALRFPKGSVIESVPAVRRIDGVDVLHASDDAAVLLVCAGAFGRLGVEAAQRLAAQGVAATVVDPRWVLPVPGAVVEMAREHRLVVTVSDSGRHGGFGSVVSAALRDAECDVPLRDVALPQEFLDHGSRDDVLAATGLTAQDVARRVTEWASALPSFTMPSDVDASDLGVES
>NZ_CP053564.1|WP_172165233.1|6159043_6159709_-|response-regulator-transcription-factor
MRVLVVEDEHPLADAIARGLRREGMAVDVAYDGDTGHEKSAVTRYDVVVLDRDLPGMTGDALCGEIVGSGATTRVLMLTASGTLADKVDGLSRGADDYLAKPFDFPELVARLRALGRRATPAVPPLLTAGDVALDPARRTVLRADRPVELTRKEFGVLEVLISAGGGVVSSEELLERVWDENADPFTTTVRVTVMTLRKKLGEPGVIETVVGAGYRVPAAG
>NZ_CP053564.1|WP_172165230.1|6157934_6159044_-|HAMP-domain-containing-histidine-kinase
MTGLRPRLTLLATALVALASALLLWLGWLLVGGVTQAVPALPPGSTVRVDGVTVPAEGLGDAVGRAAQEEVLRAGLVAFPLVVLAAALVSWVLVGRVLGPLHEVTATARRLTVETLDTRLGLADARGEVAELAAGFDAMLDRLQAAFDAQRRFVANASHELRTPLAVLRTEVDVTLSDPTADEAELRRMGAVVRDATRRADDLVAGLLLLARTEGAALADLHPADLAATVVPALAAVRAEAGHRGLRVQVRTAPAPVVGDPVLLERVAGNLVENAVRHNVPGGWIEVVSGVRDGCAELCVASSGREVDRVDELFEPFRRGPVERTATAPGSGLGLSIVRAVVTAHGGAVAAAPVPGGGLTVTVRLPVRP
>NZ_CP053564.1|WP_172169488.1|6156647_6157913_+|ribonuclease-D
MNPEDPDGSSVQEGPAATDEPEVPAPVPLLAPVDGLPPVVADRDALRATAAAFAAGTGPVAVDAERASGFKYSQRAYLVQLRRAGAGTALVDPIPLGSDLSDLAPALTGPEWVLHAASQDLACLAETGLAPSRLFDTELAGRLAGLPRVGLGPMVENLLGLALEKGHGAADWSRRPLPQDWLVYAALDVEVLVELRDVLTRMLDEQGKLDWAHQEFEAVRTAGPPTPRAEPWRRTSGIHKLRKPRQLAAVRGLWEARDRLAAERDIAPGRVLPDAAIVDAAVSAPESAGALGTMAVFRGRSQRRMTAYWWSALAAAERLDPADLPRPTAPTEGPPPVARWADRDPDAAARLVAARAAVAEVGAERTVPVENLLQPDLLRRLCWTPPEDGDVAGFLRKGGAREWQIALLTPALEQALTARST
>NZ_CP053564.1|WP_075949948.1|6155997_6156651_+|response-regulator-transcription-factor
MVPHPREELFSVLVVDDHPLLREAIAARLRSMGAGTVYEAASVAEARARAHANGPCDLAILDLGLPDGSGLDLVTELRSLGWNRLVVLASSDDPYAVRSAFQAGAQAYLLKSASAAIVTDGVKRVLDGGVYADPTVAPLLATGTRVPGTDNTPRELSAREVEVLQLVADGQSNKEIGEALSLSALTVKSHLSRIGRKLGTGDRAQMVALAMRAGVIR
>NZ_CP053564.1|WP_172165227.1|6154964_6155702_+|DUF3000-domain-containing-protein
MTGPSSHAVPGCLPPARDARRGGRGTRTGGPGAPVLPGVSRRLEFPLVPDATASPPPEFRRAVASLGTLRARPELIVSALDAPPRLAPWTWALSVEVADSTLGRAAADDGVDESDTSGRLILLHDPAGQDAWEGTFRLVCFVQARLEPEQLGDEMLPVVGWSWLTEALEDHGAEHVALGGTVTQTSSVRFGDIAGPRRDDDVELRASWTPIGTDLSRHAAAFCAFVASAAGLPPVGAVSLVHRTV
>NZ_CP053564.1|WP_172165224.1|6153880_6154966_-|uroporphyrinogen-decarboxylase
MVVNPSPSAAGTVAADTRRRELAAAPFLVAARGGRPAHLPVWFMRQAGRSLPEYRALRRDSGMLQACLTPDLTCEITLQPVRRHGVDAAILFSDIVVPLHVAGVDVDIVAGTGPVVASPVRTAEDVERLPVLDAGQIAPVTDAIALLLPELGETPLIGFAGAPFTLASYLIEGGPSRNHERTKALMRSAPGVWHALLGRLADMTTTFLRAQVAAGVDAVQLFDSWAGALSERDYREYVQPHSARVLAGLADAGVPRIHFGVGTGELLGAMAEAGADVVGVDWRIPLDDAARRAGGTHPVQGNLDPAVLFADAASIASEVGRIAAEGRRTPGHVFNLGHGVLPDTDPDVLTRLVDLVHRQPV
>NZ_CP053564.1|WP_172165221.1|6152489_6153884_-|protoporphyrinogen-oxidase
MTGPVRVAVVGGGISGLAAAHRLRALLGPDARITVLERRDRVGGVLHTVDLAGKPFDVGAEAFLARRPEVPALLAELGLPPAVHPTAASATVCAGGRTAPLPGGTLLGVPTSAARLDALLSGSGLAGVAAEPGIPLDWEPGSDAALGGLLRARFGDEIADRLADPLLGGVYAGRVDALGLRATIPALAAALDAGAPSLTAAADRATTPTGSAPGGPVFGAVPGGYRTLLDALAAAARADVRLGVTVRELVALDGGWRLVLGSTTEPEALDVDAVVLAVPAPAAAKLLAGVAPAAARAAGEIELASSVVVALAFRDADAATLPPTSGTLVAADEPLHVKGVTHSGTKWAHLAGDGVVRLRASLGRFGEAPALQVDDDELVARVRADLATLTGVTAAPVAVHVQRWGGGLPQYGVGHLDRVAAIEDGLPAGLAVAGAALHGVGVPACVATARAAAGRVAAGLTPPR
>NZ_CP053564.1|WP_172165245.1|6165241_6166468_-|MFS-transporter
MADRALGQVFAVREYRTVWIADLLSVGGDQLARVALAVLVYGRTGSAAWAAATYALTFLPAIVGGVLLSGLADRFPRREVLVVTDVVRAGLVAVMAIPQIPLAVLCALLVVVVLLGAPHTAARGALLPELLPGDLYERGLAVSQITGQTAQVVGFAAGGLLVAAVSPSSALLLDAVTFLVAGLLFRLGLVRRPRADAAPRSPGRDLLAGVVDVATDRRRRALVLLVWMVGLYVVPEALAAPYADQIGAGPAVVGLLMAADPLGSVLGAWLFVRFVPPDRRARLIGVLAVAAGLPLLFTALVPPVPVALLLWGVSGMASTAYVMQAQASFVRATPAAIRGRAIGVAASGIVAGQGVAVLAGGVLADLTTPSTAVALCAAAGVVVALGGALAWRSASADDQAMRPLPVTT
>NZ_CP053564.1|WP_172165248.1|6166529_6167150_-|histidine-phosphatase-family-protein
MQLVLVRHALPERVDGAAGAGTADPPLTAHGEAQARRVVDAVSGDAVEALYVSPMARARATAAPLAAALGVDPVVVHDLREYDADSPHYVPVHEMPVADPAGWARIVAGLLPEGVDVPAFTGRVTDALERIVADHPGRGTVVVVAHAGVVNCFLAHLLGIDRPLAFPLDYTGISRVVATRDGRRLVRTVNEIAHVADLLTPTAGTT
>NZ_CP053564.1|WP_172165251.1|6167152_6167593_-|HIT-family-protein
MTTVFTKIIDGDLPGRFVWADDLAVGFLSINPLAPGHVLVVPRAEVDHWVDADAALLAHLTTVAHAIGEAVRTVYDPPRVGLLVAGFEVPHLHLHVFPAADMAAFDFANAASSVDAAEQDGHRDALRAALRDAGHGAHVPADDPAA
>NZ_CP053564.1|WP_172165254.1|6167634_6168096_+|PPOX-class-F420-dependent-oxidoreductase
MARTVATNTTVDRGELLEFLRPRHHVILLTPRSDGGWQGSPVTSGVDAEGRIVIATYPERAKSRNVARHGRASVVVLSEDFDGAWVQVDGDAELLELPDAVEPLVEYFRSISGEHPDWDEYRRAMTDQGKALIRITPTRWSPIATGGFPARLA
>NZ_CP053564.1|WP_172169491.1|6168162_6170331_+|glycogen-debranching-protein-GlgX
MRPWPGHAYPLGATYDGAGTNFALFSEVAEKVELCLFDEDGDEKRVPLTEVDGFVWHGYLPTVEPGQRYGFRVHGPHDPGQGLRCNPHKLLIDPYAKALDGPVKWDEAVFGYQFSDPDTRNDADSAPFVPKSVVVNPFFDWGSDRPPKIPYNESVIYEAHVRGLTIAHPDIPEPLRGTYTGLAHPAMIEHLKNLGVTAVELMPVHEFLNDHHLQEKGLSNYWGYNTVAFLAPHHAYAMGNNRPGNQVQEFKAMVRDLHDAGIEVILDVVYNHTAEGNDMGPTLSMRGIDNHAYYRVVEDDQRYYMDYTGTGNSLNVRNPHTLQLIMDSLRYWVTEMHVDGFRFDLASTLAREFYDVDRLSVFFDLVQQDPVISQAKLIAEPWDVGPGGYQVGNFPPLWTEWNGKYRDTVRDFWRGEPGTLGEFAQRLTGSSDLYQNDGRRPFASINFVTAHDGFTLNDLVSYNEKHNEANGEDNNDGESHNRSWNCGVEGPTDDEAVLELRARQQRNIIATMLISQGVPMLLHGDELGRTQNGNNNVYCQDSEIAWVDWSLAGKNAPLIGFTAGMVALRHAHPVFRRRRFFAGRPIGPRRRADAAAALPDIAWFTPTGEEMTEQDWDSGFGKCVTVFLNGEGIFDVDARGERVVDDSFVIALNAHYEDIDVVLPGSRYGSRWAVVVDTTTGIVTTLATAPGMAAAEPDTVGAGDTFTVTARSLVVFQRTEGP
>NZ_CP053564.1|WP_172165257.1|6170344_6171949_-|thiamine-pyrophosphate-binding-protein
MTRTVRDATFDALRRHDLTTVFANPGSTEIALLTGLPPDLEFVLALHEGSVVGMATGYATARDRPALAVLHTTAGLGNAVGALATARVNRVPLVVLVGQQDRRHLAYRPFLAGDLDGLAGSYPVWVGRPERPQDVPGMVVRARHEAVTGRGPALVVVPSDDWSAPADDDERPAPAVLRHAAAADPAAVAELAALVDAAAAPALVVGSDADHPDTWAALVALVDCLGCPVWQEPFAARAGFPQDHPRFAGHLPAGRARLRAALAGHDLVLAVGAPVFRQYPYEPGPLVEPGTRVALVTDDAEDAHHSAADLALLAPPAAVCRALADAVAARPGTAVTTPDRTGPAAPGPGEPLRAAHVLAALAARLPAESVVVEETPSSRPDLHRLLPARRPLGFLSAAMGGLGFALPAAVGVRMGRPGTPVVAVVGDGSSLYGIQALWSAAHYGVGVLVVVLANGRYAVMDRLAEQHGGGRAPWPAFDEVSVSGLAESLGCPARRVEDHDDLLAVLDAEVPGLAARRTPLVLDVVVAPDAGFAP
>NZ_CP053564.1|WP_172165260.1|6171945_6173181_-|aromatic-acid/H+-symport-family-MFS-transporter
MTTESVARSQVGAGWVRPLCWAAVALEGYDIVVLGAVLPALLKSDWGLDPNSGALISVVGLLGIMVGALAIGPVADVIGRRRTMLLTVVGFSVLTLACAFAPGPEVFGLLRFLAGLGLGGVLPVALAMVTEYAPPGGSGSATTVLMTGYHVGAVATALLGIAVIPTLGWPAMFVIGALPALVLVPLLWRFLPESVDFLRAREPGRAAPDAPAPADPVRALFRDGYLRATLAFWVTSVMGLLLVYGLNTWLPQIMISAGYELNASLALLLTLNAGAVIGLLVAGRVADRIGTRLATITWFALGALFLALLSIRLPGIGVYVSVLLAGIFVFSAQVLCYAFVGQHYPAAVRGTALGSVSGVGRIGAIAGPLIGGALLTAGVAYPWGFYIFAGVAAVGALAVAVVVGGGRRAQA
>NZ_CP053564.1|WP_172169494.1|6173232_6173949_-|IclR-family-transcriptional-regulator
MGRGLAVLGTFAPDRPEQTLAAIAQASGLPSATAYRLVAELVGWGALEKVGRGRYRVGMRLWEVGSLAPVARGLRDAALPVLQELCAVTGHPVHLVVLDGEHALFLERLAGHAPLALRSQVGKRLPLHASGPGKVLLAHAPAEVLDAVLATGLPRVASGTITDPARLAAALAEIRRTGSCLSREEMTDGAASVAAPVVGPSGEVLAGISVVVPSDTENLTLLVPAVRMAAGAISRALH
>NZ_CP053564.1|WP_172165263.1|6174057_6176373_+|malto-oligosyltrehalose-synthase
MAPSSTYRLQFSKDTTFDDAVGLVPYLDALGVGALYASPLLESGAGSNHGYDVVDPTRVSAERGGEEGRRRLVDAVRAAGLGFVLDIVPNHVGVENAKANPWWWDVLRLGRESEHAGTFDIDWDAGPILLPILGDDSVDDLTDVDGELRYYEHAFPIAPGTGEGTPQEVHERQHYRLVHWKRGAAELTYRRFFDVSTLAAVRVEVPEIFEKTHREVLRWVEAGDVDGIRVDHPDGLAEPGTYMRLLRAAIGPDRWLLVEKILGVGEDLPASWPVDGTSGYEALREVQGLFVDPDGAGLLTQLAAEHTGGKQSLHAAEHDARREVAGTILAAEVRRIAATAARAWQTGPEPRFALTSVEDAVAELLCGFPVYRSYLPEGRDALDTAVSVARTHRPDLAEVLEAIRTTMLAEPGAELATRVQQTSGMVMAKGVEDTAFYRWNRFVALNEVGGDPARFGVSPREFHTALAVREASWPATMTTLSTHDAKRSEDVRARLAVLAEIPGEWADRFRRWSAAHPLPDRSLDLLAWQNLVGAWPISVERMAAYLGKASKEAKLVTSHVEAVAEVDEAVAAWPAAVMGDAALVAEIEEFVGRISGPGRVNSLGQKLLQIAAPGVPDVYQGTELFEYSLVDPDNRRPIDWDVRRDLLARLDGGWLPDVDAEGAAKLLVTIAALRLRRRRPGLFDGYRTVPAQGPAAGHAVAFSRSSSLVAVATRLPVGLAERGGWGDTVLPLPDAATDWHDVVSGTAVDGSAPALGTLLARYPVALLVRPE
>NZ_CP053564.1|WP_172165266.1|6176374_6177223_-|hypothetical-protein
MAGHRRGQDDTTWRAPAPSLPRALAVTAFVLGLLSIGLPNIAPDVDVLSAPGSPVRLFFGVSEEMNLPTFFSVMTFLAPACVLALAGVLAGGRIRAPFLVVALLLALLGFDDFAALHEHLKALGDLMAEGDLGAFEYAWVLPGAVIGAGVVWAFWRLATRLRGAPRRDLLLGIAVFFVASLGFETVNGFLDRPGLDGVPLQVGTHVEEVTEDLGMIIVLRGALGLVQVRRARGSVALRVADPSLVEGGPTGDDEPAAPAAPAAPAAVDAAETDRIPVVSARS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP053564_6	6.1\|5011780\|18\|NZ_CP053564\|CRISPRCasFinder	5011780-5011797	18	NZ_CP053564.1	4487191-4487208	1	0.944
NZ_CP053564_6	6.1\|5011780\|18\|NZ_CP053564\|CRISPRCasFinder	5011780-5011797	18	NZ_CP053564.1	4949713-4949730	1	0.944

1. spacer 6.1|5011780|18|NZ_CP053564|CRISPRCasFinder matches to position: 4487191-4487208, mismatch: 1, identity: 0.944

gcagctggccgaggcggc	CRISPR spacer
gctgctggccgaggcggc	Protospacer
** ***************

2. spacer 6.1|5011780|18|NZ_CP053564|CRISPRCasFinder matches to position: 4949713-4949730, mismatch: 1, identity: 0.944

gcagctggccgaggcggc	CRISPR spacer
gcggctggccgaggcggc	Protospacer
**.***************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP053564_1	1.7\|1531382\|24\|NZ_CP053564\|CRT	1531382-1531405	24	NZ_LR134456	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 14, complete sequence	69793-69816	2	0.917
NZ_CP053564_1	1.7\|1531382\|24\|NZ_CP053564\|CRT	1531382-1531405	24	NZ_LR134456	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 14, complete sequence	69589-69612	2	0.917
NZ_CP053564_1	1.7\|1531382\|24\|NZ_CP053564\|CRT	1531382-1531405	24	NZ_CP013423	Burkholderia sp. MSMB0852 plasmid pMSMB0852, complete sequence	18799-18822	3	0.875
NZ_CP053564_1	1.7\|1531382\|24\|NZ_CP053564\|CRT	1531382-1531405	24	NZ_CP028919	Gemmobacter sp. HYN0069 plasmid unnamed1, complete sequence	162935-162958	3	0.875
NZ_CP053564_1	1.7\|1531382\|24\|NZ_CP053564\|CRT	1531382-1531405	24	NZ_CP033582	Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence	628584-628607	3	0.875
NZ_CP053564_3	3.1\|3361228\|25\|NZ_CP053564\|CRISPRCasFinder	3361228-3361252	25	NC_047977	Microbacterium phage Hendrix, complete genome	23052-23076	3	0.88
NZ_CP053564_1	1.5\|1531271\|27\|NZ_CP053564\|CRT	1531271-1531297	27	NZ_LR134450	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 8, complete sequence	77601-77627	4	0.852
NZ_CP053564_1	1.7\|1531382\|24\|NZ_CP053564\|CRT	1531382-1531405	24	NZ_CP015882	Ensifer adhaerens strain Casida A plasmid pCasidaAB, complete sequence	1199282-1199305	4	0.833
NZ_CP053564_1	1.4\|1531217\|36\|NZ_CP053564\|CRT	1531217-1531252	36	NZ_LR134456	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 14, complete sequence	69655-69690	5	0.861
NZ_CP053564_3	3.1\|3361228\|25\|NZ_CP053564\|CRISPRCasFinder	3361228-3361252	25	NC_016115	Streptomyces pratensis ATCC 33331 plasmid pSFLA02, complete sequence	11772-11796	5	0.8
NZ_CP053564_7	7.1\|5012105\|28\|NZ_CP053564\|PILER-CR	5012105-5012132	28	NC_017957	Tistrella mobilis KA081020-065 plasmid pTM1, complete sequence	376172-376199	5	0.821
NZ_CP053564_7	7.1\|5012105\|28\|NZ_CP053564\|PILER-CR	5012105-5012132	28	NZ_CP030074	Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence	289696-289723	5	0.821
NZ_CP053564_7	7.2\|5012158\|30\|NZ_CP053564\|PILER-CR	5012158-5012187	30	MT952843	Gordonia phage Twonlo, complete genome	52777-52806	5	0.833
NZ_CP053564_7	7.2\|5012158\|30\|NZ_CP053564\|PILER-CR	5012158-5012187	30	KR053200	Gordonia phage GTE6, complete genome	53598-53627	5	0.833
NZ_CP053564_12	12.7\|6165189\|28\|NZ_CP053564\|CRT	6165189-6165216	28	NZ_CP024313	Rhizobium sp. NXC24 plasmid pRspNXC24b, complete sequence	426957-426984	5	0.821
NZ_CP053564_1	1.5\|1531271\|27\|NZ_CP053564\|CRT	1531271-1531297	27	MH976511	Gordonia phage Gaea, complete genome	47938-47964	6	0.778
NZ_CP053564_1	1.5\|1531271\|27\|NZ_CP053564\|CRT	1531271-1531297	27	MH651168	Gordonia phage Ashertheman, complete genome	48165-48191	6	0.778
NZ_CP053564_1	1.5\|1531271\|27\|NZ_CP053564\|CRT	1531271-1531297	27	NC_019326	Arthrobacter sp. 31-32 plasmid p3132-53, complete sequence	12099-12125	6	0.778
NZ_CP053564_7	7.1\|5012105\|28\|NZ_CP053564\|PILER-CR	5012105-5012132	28	NZ_CP022421	Sulfitobacter pseudonitzschiae strain SMR1 plasmid pSMR1-6, complete sequence	57684-57711	6	0.786
NZ_CP053564_7	7.2\|5012158\|30\|NZ_CP053564\|PILER-CR	5012158-5012187	30	NC_010372	Myxococcus fulvus strain 124B02 plasmid pMF1, complete sequence	4660-4689	6	0.8
NZ_CP053564_7	7.2\|5012158\|30\|NZ_CP053564\|PILER-CR	5012158-5012187	30	NZ_CP029831	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed7, complete sequence	2501-2530	6	0.8
NZ_CP053564_7	7.2\|5012158\|30\|NZ_CP053564\|PILER-CR	5012158-5012187	30	NC_013859	Azospirillum sp. B510 plasmid pAB510e, complete sequence	356776-356805	6	0.8
NZ_CP053564_7	7.2\|5012158\|30\|NZ_CP053564\|PILER-CR	5012158-5012187	30	NC_004931	Streptomyces sp. EN27 plasmid pEN2701, complete sequence	8133-8162	6	0.8
NZ_CP053564_1	1.3\|1531163\|36\|NZ_CP053564\|CRT	1531163-1531198	36	NZ_LR134465	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 23, complete sequence	144000-144035	7	0.806
NZ_CP053564_5	5.2\|5011333\|30\|NZ_CP053564\|CRISPRCasFinder	5011333-5011362	30	NZ_CP027299	Streptomyces sp. SGAir0924 plasmid unnamed_5	114454-114483	7	0.767
NZ_CP053564_7	7.1\|5012105\|28\|NZ_CP053564\|PILER-CR	5012105-5012132	28	NZ_CP015322	Mesorhizobium amorphae CCNWGS0123 plasmid pM0123d, complete sequence	931030-931057	7	0.75
NZ_CP053564_7	7.2\|5012158\|30\|NZ_CP053564\|PILER-CR	5012158-5012187	30	NC_012520	Rhodococcus opacus B4 plasmid pROB01, complete sequence	202259-202288	7	0.767
NZ_CP053564_7	7.2\|5012158\|30\|NZ_CP053564\|PILER-CR	5012158-5012187	30	NC_008270	Rhodococcus jostii RHA1 plasmid pRHL2, complete sequence	254892-254921	7	0.767
NZ_CP053564_7	7.2\|5012158\|30\|NZ_CP053564\|PILER-CR	5012158-5012187	30	NC_017958	Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence	431993-432022	7	0.767
NZ_CP053564_7	7.2\|5012158\|30\|NZ_CP053564\|PILER-CR	5012158-5012187	30	NZ_CP040452	Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence	1090074-1090103	7	0.767
NZ_CP053564_7	7.2\|5012158\|30\|NZ_CP053564\|PILER-CR	5012158-5012187	30	KX557279	Gordonia phage Hedwig, complete genome	23705-23734	7	0.767
NZ_CP053564_5	5.1\|5011275\|32\|NZ_CP053564\|CRISPRCasFinder	5011275-5011306	32	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	1191727-1191758	8	0.75
NZ_CP053564_5	5.1\|5011275\|32\|NZ_CP053564\|CRISPRCasFinder	5011275-5011306	32	NC_008043	Ruegeria sp. TM1040 megaplasmid, complete sequence	816156-816187	8	0.75
NZ_CP053564_5	5.1\|5011275\|32\|NZ_CP053564\|CRISPRCasFinder	5011275-5011306	32	NZ_CP032054	Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence	257883-257914	8	0.75
NZ_CP053564_5	5.1\|5011275\|32\|NZ_CP053564\|CRISPRCasFinder	5011275-5011306	32	NZ_CP032054	Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence	793458-793489	8	0.75
NZ_CP053564_5	5.1\|5011275\|32\|NZ_CP053564\|CRISPRCasFinder	5011275-5011306	32	NZ_CP016560	Streptomyces clavuligerus strain F613-1 plasmid pSCL4, complete sequence	450713-450744	8	0.75
NZ_CP053564_5	5.2\|5011333\|30\|NZ_CP053564\|CRISPRCasFinder	5011333-5011362	30	NZ_CP017588	Pantoea stewartii subsp. stewartii DC283 plasmid pDSJ07, complete sequence	50695-50724	8	0.733
NZ_CP053564_5	5.2\|5011333\|30\|NZ_CP053564\|CRISPRCasFinder	5011333-5011362	30	NZ_CP017590	Pantoea stewartii subsp. stewartii DC283 plasmid pDSJ09, complete sequence	61662-61691	8	0.733
NZ_CP053564_5	5.2\|5011333\|30\|NZ_CP053564\|CRISPRCasFinder	5011333-5011362	30	NZ_CP017590	Pantoea stewartii subsp. stewartii DC283 plasmid pDSJ09, complete sequence	120204-120233	8	0.733
NZ_CP053564_5	5.2\|5011333\|30\|NZ_CP053564\|CRISPRCasFinder	5011333-5011362	30	CP054909	Pantoea ananatis strain FDAARGOS_680 plasmid unnamed1, complete sequence	150643-150672	8	0.733
NZ_CP053564_5	5.3\|5011389\|30\|NZ_CP053564\|CRISPRCasFinder	5011389-5011418	30	NZ_CP022366	Azospirillum sp. TSH58 plasmid TSH58_p04, complete sequence	486063-486092	8	0.733
NZ_CP053564_5	5.3\|5011389\|30\|NZ_CP053564\|CRISPRCasFinder	5011389-5011418	30	NZ_CP032343	Azospirillum brasilense strain MTCC4038 plasmid p4, complete sequence	40136-40165	8	0.733
NZ_CP053564_5	5.3\|5011389\|30\|NZ_CP053564\|CRISPRCasFinder	5011389-5011418	30	NZ_CP032324	Azospirillum brasilense strain MTCC4035 plasmid p3, complete sequence	352881-352910	8	0.733
NZ_CP053564_5	5.3\|5011389\|30\|NZ_CP053564\|CRISPRCasFinder	5011389-5011418	30	NZ_CP007797	Azospirillum brasilense strain Az39 plasmid AbAZ39_p4, complete sequence	502844-502873	8	0.733
NZ_CP053564_5	5.3\|5011389\|30\|NZ_CP053564\|CRISPRCasFinder	5011389-5011418	30	NZ_CP033582	Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence	482657-482686	8	0.733
NZ_CP053564_5	5.3\|5011389\|30\|NZ_CP053564\|CRISPRCasFinder	5011389-5011418	30	NZ_CP032348	Azospirillum brasilense strain MTCC4039 plasmid p4, complete sequence	524913-524942	8	0.733
NZ_CP053564_5	5.3\|5011389\|30\|NZ_CP053564\|CRISPRCasFinder	5011389-5011418	30	NZ_CP012917	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p3, complete sequence	53275-53304	8	0.733
NZ_CP053564_7	7.2\|5012158\|30\|NZ_CP053564\|PILER-CR	5012158-5012187	30	NC_015178	Acidiphilium multivorum AIU301 plasmid pACMV1, complete sequence	213820-213849	8	0.733
NZ_CP053564_7	7.2\|5012158\|30\|NZ_CP053564\|PILER-CR	5012158-5012187	30	MH450129	Gordonia phage Ribeye, complete genome	47459-47488	8	0.733
NZ_CP053564_7	7.2\|5012158\|30\|NZ_CP053564\|PILER-CR	5012158-5012187	30	NZ_CP026654	Streptomyces dengpaensis strain XZHG99 plasmid unnamed2, complete sequence	6389-6418	8	0.733
NZ_CP053564_5	5.1\|5011275\|32\|NZ_CP053564\|CRISPRCasFinder	5011275-5011306	32	NZ_CP013110	Sinorhizobium americanum strain CFNEI 73 plasmid C, complete sequence	696575-696606	9	0.719
NZ_CP053564_5	5.1\|5011275\|32\|NZ_CP053564\|CRISPRCasFinder	5011275-5011306	32	NZ_CP032343	Azospirillum brasilense strain MTCC4038 plasmid p4, complete sequence	447987-448018	9	0.719
NZ_CP053564_5	5.1\|5011275\|32\|NZ_CP053564\|CRISPRCasFinder	5011275-5011306	32	NZ_CP013054	Sinorhizobium americanum CCGM7 plasmid C, complete sequence	1685971-1686002	9	0.719
NZ_CP053564_5	5.1\|5011275\|32\|NZ_CP053564\|CRISPRCasFinder	5011275-5011306	32	NZ_CP012917	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p3, complete sequence	280207-280238	9	0.719
NZ_CP053564_5	5.3\|5011389\|30\|NZ_CP053564\|CRISPRCasFinder	5011389-5011418	30	NC_020548	Azoarcus sp. KH32C plasmid pAZKH, complete sequence	401082-401111	9	0.7

1. spacer 1.7|1531382|24|NZ_CP053564|CRT matches to NZ_LR134456 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 14, complete sequence) position: , mismatch: 2, identity: 0.917

ggctacgaccagggctacggccag	CRISPR spacer
gcgtacgaccagggctacggccag	Protospacer
*  *********************

2. spacer 1.7|1531382|24|NZ_CP053564|CRT matches to NZ_LR134456 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 14, complete sequence) position: , mismatch: 2, identity: 0.917

ggctacgaccagggctacggccag	CRISPR spacer
ggctacgaccagaactacggccag	Protospacer
************..**********

3. spacer 1.7|1531382|24|NZ_CP053564|CRT matches to NZ_CP013423 (Burkholderia sp. MSMB0852 plasmid pMSMB0852, complete sequence) position: , mismatch: 3, identity: 0.875

ggctacgaccagggctacggccag	CRISPR spacer
ggctacgaccacggctacggccga	Protospacer
*********** **********..

4. spacer 1.7|1531382|24|NZ_CP053564|CRT matches to NZ_CP028919 (Gemmobacter sp. HYN0069 plasmid unnamed1, complete sequence) position: , mismatch: 3, identity: 0.875

ggctacgaccagggctacggccag	CRISPR spacer
ggctacggtcagggctacggccaa	Protospacer
*******..**************.

5. spacer 1.7|1531382|24|NZ_CP053564|CRT matches to NZ_CP033582 (Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence) position: , mismatch: 3, identity: 0.875

ggctacgaccagggctacggccag	CRISPR spacer
ggcgacgaccagggcaacggccat	Protospacer
*** *********** *******

6. spacer 3.1|3361228|25|NZ_CP053564|CRISPRCasFinder matches to NC_047977 (Microbacterium phage Hendrix, complete genome) position: , mismatch: 3, identity: 0.88

gcgatcgtggctctggccgtggttg	CRISPR spacer
gcgatcgtgactctggccgtcgtcg	Protospacer
*********.********** **.*

7. spacer 1.5|1531271|27|NZ_CP053564|CRT matches to NZ_LR134450 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 8, complete sequence) position: , mismatch: 4, identity: 0.852

ggctacgggcagcagcccgggtacgac	CRISPR spacer
ccctacgcgcagcagcccgggtacggc	Protospacer
  ***** *****************.*

8. spacer 1.7|1531382|24|NZ_CP053564|CRT matches to NZ_CP015882 (Ensifer adhaerens strain Casida A plasmid pCasidaAB, complete sequence) position: , mismatch: 4, identity: 0.833

ggctacgaccagggctacggccag	CRISPR spacer
ctctacgaccagggctacggcgtg	Protospacer
  *******************  *

9. spacer 1.4|1531217|36|NZ_CP053564|CRT matches to NZ_LR134456 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 14, complete sequence) position: , mismatch: 5, identity: 0.861

cagcccggctacgaccagggctacgggcagcagcag	CRISPR spacer
cagcccggctacgaccagggctaccagcagccggcg	Protospacer
************************ .***** *  *

10. spacer 3.1|3361228|25|NZ_CP053564|CRISPRCasFinder matches to NC_016115 (Streptomyces pratensis ATCC 33331 plasmid pSFLA02, complete sequence) position: , mismatch: 5, identity: 0.8

gcgatcgtggctctggccgtggttg	CRISPR spacer
gcgatcgtagctctggccgtgcgac	Protospacer
********.************

11. spacer 7.1|5012105|28|NZ_CP053564|PILER-CR matches to NC_017957 (Tistrella mobilis KA081020-065 plasmid pTM1, complete sequence) position: , mismatch: 5, identity: 0.821

cggtgccaccccggacaccggccggcgc	CRISPR spacer
cgccgccacctcgggcaccggccggcgg	Protospacer
** .******.***.************

12. spacer 7.1|5012105|28|NZ_CP053564|PILER-CR matches to NZ_CP030074 (Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.821

cggtgccaccccggacaccggccggcgc	CRISPR spacer
cgtctccaccccggtcaccgtccggcgc	Protospacer
** . ********* ***** *******

13. spacer 7.2|5012158|30|NZ_CP053564|PILER-CR matches to MT952843 (Gordonia phage Twonlo, complete genome) position: , mismatch: 5, identity: 0.833

gcaccggccggagtcgccgcgggc-acggct	CRISPR spacer
gcaccggccggcgtcgccgcggccggcagc-	Protospacer
*********** ********** * .*.**

14. spacer 7.2|5012158|30|NZ_CP053564|PILER-CR matches to KR053200 (Gordonia phage GTE6, complete genome) position: , mismatch: 5, identity: 0.833

gcaccggccggagtcgccgcgggc-acggct	CRISPR spacer
gcaccggccggcgtcgccgcggccggcagc-	Protospacer
*********** ********** * .*.**

15. spacer 12.7|6165189|28|NZ_CP053564|CRT matches to NZ_CP024313 (Rhizobium sp. NXC24 plasmid pRspNXC24b, complete sequence) position: , mismatch: 5, identity: 0.821

ccgcaagcaccccgacgagaggaacgcc	CRISPR spacer
aagccagcaccccgccgagaggaacggc	Protospacer
  ** ********* *********** *

16. spacer 1.5|1531271|27|NZ_CP053564|CRT matches to MH976511 (Gordonia phage Gaea, complete genome) position: , mismatch: 6, identity: 0.778

ggctacgggcagcagcccgggtacgac	CRISPR spacer
ggctacgggcagcagcccggcggctgg	Protospacer
********************  .* .

17. spacer 1.5|1531271|27|NZ_CP053564|CRT matches to MH651168 (Gordonia phage Ashertheman, complete genome) position: , mismatch: 6, identity: 0.778

ggctacgggcagcagcccgggtacgac	CRISPR spacer
ggctacgggcagcagcccggcggctgg	Protospacer
********************  .* .

18. spacer 1.5|1531271|27|NZ_CP053564|CRT matches to NC_019326 (Arthrobacter sp. 31-32 plasmid p3132-53, complete sequence) position: , mismatch: 6, identity: 0.778

ggctacgggcagcagcccgggtacgac	CRISPR spacer
agctacgggaagcagcctgggtacccg	Protospacer
.******** *******.******

19. spacer 7.1|5012105|28|NZ_CP053564|PILER-CR matches to NZ_CP022421 (Sulfitobacter pseudonitzschiae strain SMR1 plasmid pSMR1-6, complete sequence) position: , mismatch: 6, identity: 0.786

cggtgccaccccggacaccggccggcgc	CRISPR spacer
gcgtgccaccccagccaccggccggcag	Protospacer
  **********.* ***********.

20. spacer 7.2|5012158|30|NZ_CP053564|PILER-CR matches to NC_010372 (Myxococcus fulvus strain 124B02 plasmid pMF1, complete sequence) position: , mismatch: 6, identity: 0.8

gcaccggccggagtcgccgcgggcacggct	CRISPR spacer
ggcgcggccggcgtcgccgcgagcacggca	Protospacer
*   ******* *********.*******

21. spacer 7.2|5012158|30|NZ_CP053564|PILER-CR matches to NZ_CP029831 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed7, complete sequence) position: , mismatch: 6, identity: 0.8

gcaccggc-----cggagtcgccgcgggcacggct	CRISPR spacer
-----ggcgaccgcggagtcgccgcgcgcacggct	Protospacer
     ***     ************* ********

22. spacer 7.2|5012158|30|NZ_CP053564|PILER-CR matches to NC_013859 (Azospirillum sp. B510 plasmid pAB510e, complete sequence) position: , mismatch: 6, identity: 0.8

gcaccggccggagtcgccgcgggcacggct	CRISPR spacer
gccgcggccggagccgccgcgggcaccggc	Protospacer
**  *********.************ * .

23. spacer 7.2|5012158|30|NZ_CP053564|PILER-CR matches to NC_004931 (Streptomyces sp. EN27 plasmid pEN2701, complete sequence) position: , mismatch: 6, identity: 0.8

gcaccggccggagtcgccgcgggcacggct-	CRISPR spacer
ccgccggccggagtcggcgcgggc-caactc	Protospacer
 *.************* ******* *..**

24. spacer 1.3|1531163|36|NZ_CP053564|CRT matches to NZ_LR134465 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 23, complete sequence) position: , mismatch: 7, identity: 0.806

cagcagggtggctacggccagcagcccgggtacgac	CRISPR spacer
cagcagggcggctacggtcagcagcccgcgcagcag	Protospacer
********.********.********** *.*  *

25. spacer 5.2|5011333|30|NZ_CP053564|CRISPRCasFinder matches to NZ_CP027299 (Streptomyces sp. SGAir0924 plasmid unnamed_5) position: , mismatch: 7, identity: 0.767

gctcctcggcggggccggtacccggcgcga	CRISPR spacer
gggcggcggcgcggccggtacccgtcgcgc	Protospacer
*  *  ***** ************ ****

26. spacer 7.1|5012105|28|NZ_CP053564|PILER-CR matches to NZ_CP015322 (Mesorhizobium amorphae CCNWGS0123 plasmid pM0123d, complete sequence) position: , mismatch: 7, identity: 0.75

cggtgccaccccggacaccggccggcgc	CRISPR spacer
atctgccgccccggacaccgggcggctt	Protospacer
   ****.************* **** .

27. spacer 7.2|5012158|30|NZ_CP053564|PILER-CR matches to NC_012520 (Rhodococcus opacus B4 plasmid pROB01, complete sequence) position: , mismatch: 7, identity: 0.767

gcaccggccggagtcgccgcgggcacggct	CRISPR spacer
gaggtggccggagtcgcggcggccacggca	Protospacer
* . .************ **** ******

28. spacer 7.2|5012158|30|NZ_CP053564|PILER-CR matches to NC_008270 (Rhodococcus jostii RHA1 plasmid pRHL2, complete sequence) position: , mismatch: 7, identity: 0.767

gcaccggccggagtcgccgcgggcacggct	CRISPR spacer
gcgggtgccggggtcgccgcgggcaccgcg	Protospacer
**.   *****.************** **

29. spacer 7.2|5012158|30|NZ_CP053564|PILER-CR matches to NC_017958 (Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence) position: , mismatch: 7, identity: 0.767

gcaccggccggagtcgccgcgggcacggct	CRISPR spacer
gcacgggccgaagtcgccgcggggctgggc	Protospacer
**** *****.************  .** .

30. spacer 7.2|5012158|30|NZ_CP053564|PILER-CR matches to NZ_CP040452 (Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

gcaccggccggagtcgccgcgggcacggct	CRISPR spacer
gatgccgccgaagtcgccgcgggaacggcc	Protospacer
*   * ****.************ *****.

31. spacer 7.2|5012158|30|NZ_CP053564|PILER-CR matches to KX557279 (Gordonia phage Hedwig, complete genome) position: , mismatch: 7, identity: 0.767

gcaccggccggagtcgccgcgggcacggct	CRISPR spacer
gtgcagggcggcgtcgccgcgggcacgggc	Protospacer
*..* ** *** **************** .

32. spacer 5.1|5011275|32|NZ_CP053564|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 8, identity: 0.75

gcggcttgccgcgttcggttccgccggtgctg	CRISPR spacer
gagcgcggtcgcgttccgttccgacggtgctg	Protospacer
* *  . *.******* ****** ********

33. spacer 5.1|5011275|32|NZ_CP053564|CRISPRCasFinder matches to NC_008043 (Ruegeria sp. TM1040 megaplasmid, complete sequence) position: , mismatch: 8, identity: 0.75

gcggctt--gccgcgttcggttccgccggtgctg	CRISPR spacer
--gacctaggccgagttcggttccgccggggcgc	Protospacer
  *.*.*  **** *************** **

34. spacer 5.1|5011275|32|NZ_CP053564|CRISPRCasFinder matches to NZ_CP032054 (Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence) position: , mismatch: 8, identity: 0.75

gcggcttgccgcgttcggttccgccggtgctg	CRISPR spacer
gagcgcggtcgcgttccgttccgacggtgctg	Protospacer
* *  . *.******* ****** ********

35. spacer 5.1|5011275|32|NZ_CP053564|CRISPRCasFinder matches to NZ_CP032054 (Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence) position: , mismatch: 8, identity: 0.75

gcggcttgccgcgttcggttccgccggtgctg	CRISPR spacer
gagcgcggtcgcgttccgttccgacggtgctg	Protospacer
* *  . *.******* ****** ********

36. spacer 5.1|5011275|32|NZ_CP053564|CRISPRCasFinder matches to NZ_CP016560 (Streptomyces clavuligerus strain F613-1 plasmid pSCL4, complete sequence) position: , mismatch: 8, identity: 0.75

gcggcttgccgcgttcggttccgccggtgctg	CRISPR spacer
gagcgcggtcgcgttccgttccgacggtgctg	Protospacer
* *  . *.******* ****** ********

37. spacer 5.2|5011333|30|NZ_CP053564|CRISPRCasFinder matches to NZ_CP017588 (Pantoea stewartii subsp. stewartii DC283 plasmid pDSJ07, complete sequence) position: , mismatch: 8, identity: 0.733

gctcctcggcggggccggtacccggcgcga	CRISPR spacer
gctcatcggcgggcccggtacccccgaagc	Protospacer
**** ******** *********   . *

38. spacer 5.2|5011333|30|NZ_CP053564|CRISPRCasFinder matches to NZ_CP017590 (Pantoea stewartii subsp. stewartii DC283 plasmid pDSJ09, complete sequence) position: , mismatch: 8, identity: 0.733

gctcctcggcggggccggtacccggcgcga	CRISPR spacer
gctcatcggcgggcccggtacccccgaagc	Protospacer
**** ******** *********   . *

39. spacer 5.2|5011333|30|NZ_CP053564|CRISPRCasFinder matches to NZ_CP017590 (Pantoea stewartii subsp. stewartii DC283 plasmid pDSJ09, complete sequence) position: , mismatch: 8, identity: 0.733

gctcctcggcggggccggtacccggcgcga	CRISPR spacer
gctcatcggcgggcccggtacccccgaagc	Protospacer
**** ******** *********   . *

40. spacer 5.2|5011333|30|NZ_CP053564|CRISPRCasFinder matches to CP054909 (Pantoea ananatis strain FDAARGOS_680 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

gctcctcggcggggccggtacccggcgcga	CRISPR spacer
gctcatcggcgggcccggtacccccgaagc	Protospacer
**** ******** *********   . *

41. spacer 5.3|5011389|30|NZ_CP053564|CRISPRCasFinder matches to NZ_CP022366 (Azospirillum sp. TSH58 plasmid TSH58_p04, complete sequence) position: , mismatch: 8, identity: 0.733

tctgctcgccggggctggtacccggcgctg	CRISPR spacer
gtgccgagccggggctggtagacggcgctg	Protospacer
 .  *  *************  ********

42. spacer 5.3|5011389|30|NZ_CP053564|CRISPRCasFinder matches to NZ_CP032343 (Azospirillum brasilense strain MTCC4038 plasmid p4, complete sequence) position: , mismatch: 8, identity: 0.733

tctgctcgccggggctggtacccggcgctg	CRISPR spacer
gtgccgagccggggctggtagacggcgctg	Protospacer
 .  *  *************  ********

43. spacer 5.3|5011389|30|NZ_CP053564|CRISPRCasFinder matches to NZ_CP032324 (Azospirillum brasilense strain MTCC4035 plasmid p3, complete sequence) position: , mismatch: 8, identity: 0.733

tctgctcgccggggctggtacccggcgctg	CRISPR spacer
gtgccgagccggggctggtagacggcgctg	Protospacer
 .  *  *************  ********

44. spacer 5.3|5011389|30|NZ_CP053564|CRISPRCasFinder matches to NZ_CP007797 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p4, complete sequence) position: , mismatch: 8, identity: 0.733

tctgctcgccggggctggtacccggcgctg	CRISPR spacer
gtgccgagccggggctggtagacggcgctg	Protospacer
 .  *  *************  ********

45. spacer 5.3|5011389|30|NZ_CP053564|CRISPRCasFinder matches to NZ_CP033582 (Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence) position: , mismatch: 8, identity: 0.733

tctgctcgccggggctggtacccggcgctg	CRISPR spacer
gaaggtcgccggggctggtgcccgtcgcct	Protospacer
   * **************.**** ***.

46. spacer 5.3|5011389|30|NZ_CP053564|CRISPRCasFinder matches to NZ_CP032348 (Azospirillum brasilense strain MTCC4039 plasmid p4, complete sequence) position: , mismatch: 8, identity: 0.733

tctgctcgccggggctggtacccggcgctg	CRISPR spacer
gtgccgagccggggctggtagacggcgctg	Protospacer
 .  *  *************  ********

47. spacer 5.3|5011389|30|NZ_CP053564|CRISPRCasFinder matches to NZ_CP012917 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p3, complete sequence) position: , mismatch: 8, identity: 0.733

tctgctcgccggggctggtacccggcgctg	CRISPR spacer
gtgccgagccggggctggtagacggcgctg	Protospacer
 .  *  *************  ********

48. spacer 7.2|5012158|30|NZ_CP053564|PILER-CR matches to NC_015178 (Acidiphilium multivorum AIU301 plasmid pACMV1, complete sequence) position: , mismatch: 8, identity: 0.733

gcaccggccggagtcgccgcgggcacggct	CRISPR spacer
accgtcgccgcagtcggcgcgggcacggcg	Protospacer
.*  . **** ***** ************

49. spacer 7.2|5012158|30|NZ_CP053564|PILER-CR matches to MH450129 (Gordonia phage Ribeye, complete genome) position: , mismatch: 8, identity: 0.733

gcaccggccggagtcgccgcgggcacggct	CRISPR spacer
aggctggccggcgtcgccgcgggcaccgag	Protospacer
. .*.****** ************** *

50. spacer 7.2|5012158|30|NZ_CP053564|PILER-CR matches to NZ_CP026654 (Streptomyces dengpaensis strain XZHG99 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.733

gcaccggccggagtcgccgcgggcacggct	CRISPR spacer
ccaccggccggaggcgtcgcgggcgacgtc	Protospacer
 ************ **.*******.  *..

51. spacer 5.1|5011275|32|NZ_CP053564|CRISPRCasFinder matches to NZ_CP013110 (Sinorhizobium americanum strain CFNEI 73 plasmid C, complete sequence) position: , mismatch: 9, identity: 0.719

gcggcttgccgcgttcggttccgccggtgctg	CRISPR spacer
cgagcttgccgaggtcggttccgccgatcatc	Protospacer
  .******** * ************.*  *

52. spacer 5.1|5011275|32|NZ_CP053564|CRISPRCasFinder matches to NZ_CP032343 (Azospirillum brasilense strain MTCC4038 plasmid p4, complete sequence) position: , mismatch: 9, identity: 0.719

gcggcttgccgcgttcggttccgccggtgctg	CRISPR spacer
aaccgtcgccgcgttcggtgccggcggtgccg	Protospacer
.    *.************ *** ******.*

53. spacer 5.1|5011275|32|NZ_CP053564|CRISPRCasFinder matches to NZ_CP013054 (Sinorhizobium americanum CCGM7 plasmid C, complete sequence) position: , mismatch: 9, identity: 0.719

gcggcttgccgcgttcggttccgccggtgctg	CRISPR spacer
cgagcttgccgaggtcggttccgccgatcatc	Protospacer
  .******** * ************.*  *

54. spacer 5.1|5011275|32|NZ_CP053564|CRISPRCasFinder matches to NZ_CP012917 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p3, complete sequence) position: , mismatch: 9, identity: 0.719

gcggcttgccgcgttcggttccgccggtgctg	CRISPR spacer
aaccgtcgccgcgttcggtgccggcggtgccg	Protospacer
.    *.************ *** ******.*

55. spacer 5.3|5011389|30|NZ_CP053564|CRISPRCasFinder matches to NC_020548 (Azoarcus sp. KH32C plasmid pAZKH, complete sequence) position: , mismatch: 9, identity: 0.7

tctgctcgccggggctggtacccggcgctg	CRISPR spacer
cgtgttcgccggggctggcacccggtaagt	Protospacer
. **.*************.******..

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2650699 : 2662782

Gordonia_phage(50.0%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_172158242.1\|2650699_2651623_-	hypothetical protein	A0A1C9EHT7	Gordonia_phage	5.9e-90	54.4
WP_172158244.1\|2651636_2652008_-	DUF2190 family protein	A0A142K8P7	Gordonia_phage	3.7e-19	46.9
WP_172158246.1\|2652011_2653319_-\|protease	ATP-dependent Clp protease proteolytic subunit	A0A2K9VH82	Gordonia_phage	2.2e-69	40.0
WP_172158249.1\|2653311_2654568_-	hypothetical protein	A0A142K8P5	Gordonia_phage	6.1e-146	65.1
WP_172158251.1\|2654592_2656227_-	hypothetical protein	A0A2D1GPK4	Mycobacterium_phage	3.6e-37	27.5
WP_172158254.1\|2656132_2656582_-	hypothetical protein	NA	NA	NA	NA
WP_172158256.1\|2657243_2657603_-	hypothetical protein	NA	NA	NA	NA
WP_172158259.1\|2657611_2658409_-	hypothetical protein	G1BSL2	Mycobacterium_virus	3.2e-07	37.2
WP_172158261.1\|2658463_2658802_-	hypothetical protein	NA	NA	NA	NA
WP_172158264.1\|2658798_2659389_-	HNH endonuclease	A0A2I7RHS8	Vibrio_phage	1.5e-17	34.8
WP_172158266.1\|2659444_2660011_-	hypothetical protein	A0A2K9VEY9	Mycobacterium_phage	2.8e-05	24.1
WP_172158269.1\|2660007_2660979_-	DNA cytosine methyltransferase	A0A088FRI5	Mycobacterium_phage	1.4e-113	65.3
WP_172158271.1\|2660975_2661332_-	hypothetical protein	NA	NA	NA	NA
WP_172158274.1\|2661328_2661616_-	hypothetical protein	NA	NA	NA	NA
WP_172158276.1\|2661612_2661957_-	hypothetical protein	NA	NA	NA	NA
WP_172158279.1\|2661953_2662181_-	hypothetical protein	NA	NA	NA	NA
WP_172158281.1\|2662177_2662345_-	hypothetical protein	NA	NA	NA	NA
WP_172158282.1\|2662341_2662782_-	hypothetical protein	A0A2H4PFF7	Gordonia_phage	6.9e-12	45.9

DBSCAN-SWA_2

4148282 : 4200992

Corynebacterium_phage(33.33%)

integrase,transposase,protease

attL 4148224:4148283|attR 4200992:4202413

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
4148224:4148283	attL	NA	NA	NA	NA
WP_172160996.1\|4148282_4149518_-\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	6.1e-106	52.2
WP_172160998.1\|4150565_4150943_+	hypothetical protein	NA	NA	NA	NA
WP_172161000.1\|4151095_4152415_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_172168703.1\|4152554_4153349_+	DUF3105 domain-containing protein	NA	NA	NA	NA
WP_172161002.1\|4153345_4154077_+	DUF305 domain-containing protein	NA	NA	NA	NA
WP_172161004.1\|4154186_4155776_+	polyprenol phosphomannose-dependent alpha 1,6 mannosyltransferase MptB	NA	NA	NA	NA
WP_172161006.1\|4155855_4157091_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_172161008.1\|4157441_4157942_-	L,D-transpeptidase	NA	NA	NA	NA
WP_172161010.1\|4158120_4158927_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_172161012.1\|4158868_4159282_-	hypothetical protein	NA	NA	NA	NA
WP_172161014.1\|4160025_4161477_+	cytochrome c oxidase assembly protein	NA	NA	NA	NA
WP_172161016.1\|4161477_4161753_-	hypothetical protein	NA	NA	NA	NA
WP_172161018.1\|4161807_4162716_-	cation transporter	NA	NA	NA	NA
WP_172161020.1\|4163105_4163600_+	hypothetical protein	NA	NA	NA	NA
WP_172161022.1\|4163747_4164719_-	cytochrome c oxidase assembly protein	NA	NA	NA	NA
WP_172161024.1\|4164718_4166977_-	copper-translocating P-type ATPase	A0A218MNH6	uncultured_virus	6.5e-98	35.6
WP_172161026.1\|4167278_4167857_-	histidine phosphatase family protein	NA	NA	NA	NA
WP_172161028.1\|4167987_4168197_+	CbtB-domain containing protein	NA	NA	NA	NA
WP_172161030.1\|4168214_4168958_+	CbtA family protein	NA	NA	NA	NA
WP_172161032.1\|4168996_4169305_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_172161034.1\|4169301_4170279_+	hypothetical protein	NA	NA	NA	NA
WP_172161036.1\|4170275_4170689_+	hypothetical protein	NA	NA	NA	NA
WP_172161038.1\|4170688_4171993_+	hypothetical protein	NA	NA	NA	NA
WP_172161040.1\|4172036_4173059_-	hypothetical protein	A0A222YZS8	Streptomyces_phage	2.0e-38	61.4
WP_172168706.1\|4173251_4174388_-	ZIP family metal transporter	NA	NA	NA	NA
WP_172161051.1\|4174522_4175578_-	multicopper oxidase domain-containing protein	NA	NA	NA	NA
WP_172161053.1\|4175574_4176276_-	metal-dependent transcriptional regulator	NA	NA	NA	NA
WP_172161055.1\|4176580_4177579_-	hypothetical protein	NA	NA	NA	NA
WP_172161057.1\|4177683_4178316_-	hypothetical protein	NA	NA	NA	NA
WP_172168727.1\|4178346_4179441_-	nitroreductase family deazaflavin-dependent oxidoreductase	NA	NA	NA	NA
WP_172161059.1\|4179491_4179752_-	hypothetical protein	NA	NA	NA	NA
WP_172161061.1\|4179836_4182713_-	AAA family ATPase	NA	NA	NA	NA
WP_172153787.1\|4183429_4184065_-	hypothetical protein	NA	NA	NA	NA
WP_172168730.1\|4184156_4185278_-	NAD(P)-binding domain-containing protein	A0A2H4J2Q2	uncultured_Caudovirales_phage	1.2e-12	28.3
WP_172161063.1\|4185759_4186908_+	DUF932 domain-containing protein	A0A140G6E9	Arthrobacter_phage	3.9e-99	51.2
WP_172161065.1\|4186999_4187719_+	hypothetical protein	NA	NA	NA	NA
WP_172153788.1\|4188171_4189761_-	hypothetical protein	NA	NA	NA	NA
WP_172168733.1\|4189966_4191181_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_172168736.1\|4191263_4193603_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_172161067.1\|4193599_4193827_+	hypothetical protein	NA	NA	NA	NA
WP_172161069.1\|4193883_4194423_+	hypothetical protein	V5UQR1	Mycobacterium_phage	6.7e-09	34.3
WP_172161071.1\|4194494_4194983_+	hypothetical protein	NA	NA	NA	NA
WP_172161073.1\|4195251_4195707_+	single-stranded DNA-binding protein	A0A1J0MC68	Streptomyces_phage	8.7e-18	43.6
WP_172161075.1\|4196019_4196862_+	bifunctional DNA primase/polymerase	NA	NA	NA	NA
WP_172161077.1\|4197239_4197461_+	hypothetical protein	NA	NA	NA	NA
WP_172161079.1\|4197763_4199551_+	DUF4041 domain-containing protein	A0A220NQR9	Corynebacterium_phage	4.3e-52	43.8
WP_172160996.1\|4199756_4200992_+\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	6.1e-106	52.2
4200992:4202413	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP053567

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP053564

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection