CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP053932	Bacillus thuringiensis strain FDAARGOS_794 plasmid unnamed1, complete sequence	0 crisprs	NA	0	0	0	0
NZ_CP053935	Bacillus thuringiensis strain FDAARGOS_794 plasmid unnamed3, complete sequence	0 crisprs	NA	0	0	0	0
NZ_CP053933	Bacillus thuringiensis strain FDAARGOS_794 plasmid unnamed2, complete sequence	0 crisprs	NA	0	0	2	3
NZ_CP053934	Bacillus thuringiensis strain FDAARGOS_794 chromosome, complete genome	4 crisprs	csa3,cas3,DEDDh,cas14j,WYL,DinG,cas14k	1	2	4	0
NZ_CP053936	Bacillus thuringiensis strain FDAARGOS_794 plasmid unnamed4, complete sequence	0 crisprs	NA	0	0	2	3

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1483 : 12682

Bacillus_phage(68.75%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_042510718.1\|1483_1747_-	hypothetical protein	A0A0S2GLK4	Bacillus_phage	5.2e-23	61.4
WP_042510717.1\|1743_2031_-	hypothetical protein	A0A1B1P7W1	Bacillus_phage	3.5e-33	77.9
WP_042510716.1\|1945_2209_-	hypothetical protein	A0A1B1P8D7	Bacillus_phage	3.7e-21	79.3
WP_042510715.1\|2212_3031_-	ATP-binding protein	A0A1B0T6C3	Bacillus_phage	1.1e-87	63.3
WP_042510714.1\|2954_3812_-	conserved phage C-terminal domain-containing protein	A0A1W6JP67	Staphylococcus_phage	7.1e-37	44.5
WP_042510712.1\|4033_4216_-	hypothetical protein	A0A1B1P897	Bacillus_phage	7.2e-16	63.6
WP_052495356.1\|4205_4856_-	hypothetical protein	A0A0C5K996	Enterococcus_phage	2.4e-37	41.1
WP_042510711.1\|4869_5565_-	ERF family protein	A0A2H4J7J4	uncultured_Caudovirales_phage	1.4e-38	50.4
WP_042510710.1\|5561_6044_-	siphovirus Gp157 family protein	E5DV79	Deep-sea_thermophilic_phage	9.4e-39	51.9
WP_000655888.1\|6056_6206_-	hypothetical protein	A0A0M5M3T1	Bacillus_phage	1.8e-09	72.1
WP_172871170.1\|6640_6784_-	hypothetical protein	A0A1B1P8A8	Bacillus_phage	6.0e-18	95.7
WP_042510709.1\|6896_7667_-	phage antirepressor KilAC domain-containing protein	A0A075KK42	Lactobacillus_phage	2.9e-42	39.9
WP_000693792.1\|7753_7948_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_042510708.1\|8140_8497_+	helix-turn-helix transcriptional regulator	A0A288WFW4	Bacillus_phage	2.8e-16	42.3
WP_165570320.1\|8808_8964_-	hypothetical protein	NA	NA	NA	NA
WP_042510707.1\|8960_10136_-	hypothetical protein	A0A1B1P895	Bacillus_phage	6.0e-103	47.2
WP_042510706.1\|10626_10974_+	helix-turn-helix transcriptional regulator	A0A1B1P888	Bacillus_phage	2.4e-20	45.4
WP_042510705.1\|11114_11903_-	exosporium leader peptide-containing protein	NA	NA	NA	NA
WP_042510704.1\|12091_12682_+	DUF4352 domain-containing protein	A0A1B1P898	Bacillus_phage	8.2e-61	98.4

DBSCAN-SWA_2

25527 : 50166

Bacillus_phage(52.63%)

capsid,tail,plate,portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_042510689.1\|25527_26118_-	DUF3967 domain-containing protein	A0A1Z1LZN4	Bacillus_phage	5.1e-10	35.1
WP_042510750.1\|26246_26510_-	DUF3937 family protein	NA	NA	NA	NA
WP_080773541.1\|26662_26866_-	hypothetical protein	A6XML4	Bacillus_virus	8.0e-08	55.8
WP_000720260.1\|26889_27570_-	S-layer homology domain-containing protein	NA	NA	NA	NA
WP_042510749.1\|27985_29251_+	Y-family DNA polymerase	O64031	Bacillus_phage	6.6e-108	48.3
WP_042510748.1\|29247_29589_+	YolD-like family protein	NA	NA	NA	NA
WP_042510747.1\|29617_30379_-	N-acetylmuramoyl-L-alanine amidase	A0A1B1P7G0	Bacillus_phage	6.1e-125	85.4
WP_042510746.1\|30378_30585_-	hypothetical protein	D2XR32	Bacillus_phage	7.6e-30	93.9
WP_001156199.1\|30586_30820_-	hemolysin XhlA family protein	A0A1B1P887	Bacillus_phage	3.3e-29	94.8
WP_042510745.1\|30871_31264_-	hypothetical protein	NA	NA	NA	NA
WP_042510744.1\|31399_32071_-	hypothetical protein	A0A1B1P805	Bacillus_phage	7.7e-55	63.9
WP_042510743.1\|32083_33721_-\|plate	BppU family phage baseplate upper protein	B5LPS6	Bacillus_virus	6.0e-85	42.8
WP_042510742.1\|33736_34006_-	transcriptional regulator	NA	NA	NA	NA
WP_042510741.1\|34015_35863_-\|tail	phage tail protein	A0A2P1JTV8	Anoxybacillus_phage	5.8e-129	56.4
WP_042510740.1\|35874_36756_-\|tail	phage tail family protein	A0A2P1JTW0	Anoxybacillus_phage	2.8e-73	46.9
WP_042510739.1\|36755_39482_-\|tail	tail length tape measure protein	B5LPS3	Bacillus_virus	9.4e-75	46.4
WP_000424144.1\|39497_39758_-	hypothetical protein	NA	NA	NA	NA
WP_001210040.1\|39835_40252_-	hypothetical protein	NA	NA	NA	NA
WP_000852367.1\|40317_40782_-\|tail	phage major tail protein, TP901-1 family	NA	NA	NA	NA
WP_042510738.1\|40796_41198_-	hypothetical protein	NA	NA	NA	NA
WP_042510737.1\|41200_41692_-	HK97 gp10 family phage protein	A0A249XXA4	Clostridium_phage	1.1e-39	50.3
WP_042510736.1\|41676_42069_-	DUF3599 family protein	NA	NA	NA	NA
WP_042510735.1\|42068_42458_-	DUF3199 family protein	A0A1B1P7D6	Bacillus_phage	2.7e-20	39.2
WP_071713421.1\|42463_42631_-	hypothetical protein	NA	NA	NA	NA
WP_042510734.1\|42637_43567_-\|capsid	phage major capsid protein	A0A1B1P7E3	Bacillus_phage	2.5e-120	72.0
WP_042510733.1\|43588_44599_-	hypothetical protein	A0A1B1IMM2	Lactococcus_phage	9.2e-52	42.4
WP_042510732.1\|44645_45572_-	hypothetical protein	A0A1B1P7D7	Bacillus_phage	4.3e-48	36.7
WP_042510731.1\|45558_47097_-\|portal	phage portal protein	A0A1B1P7C8	Bacillus_phage	3.0e-94	39.4
WP_080773542.1\|48188_48839_-	hypothetical protein	A0A2R4P8H7	Staphylococcus_phage	1.4e-45	41.0
WP_042510728.1\|49365_50166_-	hypothetical protein	D2XPX8	Bacillus_virus	5.4e-55	64.3

Anti-CRISPR protein detection

Acr_ID: NZ_CP053936.1|WP_165570320.1|8808_8964_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr_ID: NZ_CP053936.1|WP_042510707.1|8960_10136_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr_ID: NZ_CP053936.1|WP_172871170.1|6640_6784_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_CP053936.1|WP_165570320.1|8808_8964_-|hypothetical-protein

8808_8964_-

51 aa aa

1483-12682

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP053934_1	Orphan	1.26\|438840\|20\|NZ_CP053934\|CRT	438840-438859	20	11759-11740	2

1. spacer 1.26|438840|20|NZ_CP053934|CRT matches to NZ_CP053936 position: 11759-11740, mismatch: 2

gcaacaggaagcacaggtcc	CRISPR spacer
gcaacaggaataacaggtcc	Protospacer
**********  ********

NZ_CP053936.1|WP_042510707.1|8960_10136_-|hypothetical-protein

8960_10136_-

391 aa aa

1483-12682

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP053934_1	Orphan	1.26\|438840\|20\|NZ_CP053934\|CRT	438840-438859	20	11759-11740	2

1. spacer 1.26|438840|20|NZ_CP053934|CRT matches to NZ_CP053936 position: 11759-11740, mismatch: 2

gcaacaggaagcacaggtcc	CRISPR spacer
gcaacaggaataacaggtcc	Protospacer
**********  ********

NZ_CP053936.1|WP_172871170.1|6640_6784_-|hypothetical-protein

6640_6784_-

47 aa aa

1483-12682

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP053934_1	Orphan	1.26\|438840\|20\|NZ_CP053934\|CRT	438840-438859	20	11759-11740	2

1. spacer 1.26|438840|20|NZ_CP053934|CRT matches to NZ_CP053936 position: 11759-11740, mismatch: 2

gcaacaggaagcacaggtcc	CRISPR spacer
gcaacaggaataacaggtcc	Protospacer
**********  ********

2. NZ_CP053933

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

3013 : 27652

Bacillus_phage(52.63%)

plate,tail,portal,capsid

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_042510728.1\|3013_3814_+	hypothetical protein	D2XPX8	Bacillus_virus	5.4e-55	64.3
WP_080773542.1\|4340_4991_+	hypothetical protein	A0A2R4P8H7	Staphylococcus_phage	1.4e-45	41.0
WP_042510731.1\|6082_7621_+\|portal	phage portal protein	A0A1B1P7C8	Bacillus_phage	3.0e-94	39.4
WP_042510732.1\|7607_8534_+	hypothetical protein	A0A1B1P7D7	Bacillus_phage	4.3e-48	36.7
WP_042510733.1\|8580_9591_+	hypothetical protein	A0A1B1IMM2	Lactococcus_phage	9.2e-52	42.4
WP_042510734.1\|9612_10542_+\|capsid	phage major capsid protein	A0A1B1P7E3	Bacillus_phage	2.5e-120	72.0
WP_071713421.1\|10548_10716_+	hypothetical protein	NA	NA	NA	NA
WP_042510735.1\|10721_11111_+	DUF3199 family protein	A0A1B1P7D6	Bacillus_phage	2.7e-20	39.2
WP_042510736.1\|11110_11503_+	DUF3599 family protein	NA	NA	NA	NA
WP_042510737.1\|11487_11979_+	HK97 gp10 family phage protein	A0A249XXA4	Clostridium_phage	1.1e-39	50.3
WP_042510738.1\|11981_12383_+	hypothetical protein	NA	NA	NA	NA
WP_000852367.1\|12397_12862_+\|tail	phage major tail protein, TP901-1 family	NA	NA	NA	NA
WP_001210040.1\|12927_13344_+	hypothetical protein	NA	NA	NA	NA
WP_000424144.1\|13421_13682_+	hypothetical protein	NA	NA	NA	NA
WP_042510739.1\|13697_16424_+\|tail	tail length tape measure protein	B5LPS3	Bacillus_virus	9.4e-75	46.4
WP_042510740.1\|16423_17305_+\|tail	phage tail family protein	A0A2P1JTW0	Anoxybacillus_phage	2.8e-73	46.9
WP_042510741.1\|17316_19164_+\|tail	phage tail protein	A0A2P1JTV8	Anoxybacillus_phage	5.8e-129	56.4
WP_042510742.1\|19173_19443_+	transcriptional regulator	NA	NA	NA	NA
WP_042510743.1\|19458_21096_+\|plate	BppU family phage baseplate upper protein	B5LPS6	Bacillus_virus	6.0e-85	42.8
WP_042510744.1\|21108_21780_+	hypothetical protein	A0A1B1P805	Bacillus_phage	7.7e-55	63.9
WP_042510745.1\|21915_22308_+	hypothetical protein	NA	NA	NA	NA
WP_001156199.1\|22359_22593_+	hemolysin XhlA family protein	A0A1B1P887	Bacillus_phage	3.3e-29	94.8
WP_042510746.1\|22594_22801_+	hypothetical protein	D2XR32	Bacillus_phage	7.6e-30	93.9
WP_042510747.1\|22800_23562_+	N-acetylmuramoyl-L-alanine amidase	A0A1B1P7G0	Bacillus_phage	6.1e-125	85.4
WP_042510748.1\|23590_23932_-	YolD-like family protein	NA	NA	NA	NA
WP_042510749.1\|23928_25194_-	Y-family DNA polymerase	O64031	Bacillus_phage	6.6e-108	48.3
WP_000720260.1\|25609_26290_+	S-layer homology domain-containing protein	NA	NA	NA	NA
WP_080773541.1\|26313_26517_+	hypothetical protein	A6XML4	Bacillus_virus	8.0e-08	55.8
WP_042510750.1\|26669_26933_+	DUF3937 family protein	NA	NA	NA	NA
WP_042510689.1\|27061_27652_+	DUF3967 domain-containing protein	A0A1Z1LZN4	Bacillus_phage	5.1e-10	35.1

DBSCAN-SWA_2

40497 : 55226

Bacillus_phage(68.42%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_042510704.1\|40497_41088_-	DUF4352 domain-containing protein	A0A1B1P898	Bacillus_phage	8.2e-61	98.4
WP_042510705.1\|41276_42065_+	exosporium leader peptide-containing protein	NA	NA	NA	NA
WP_042510706.1\|42205_42553_-	helix-turn-helix transcriptional regulator	A0A1B1P888	Bacillus_phage	2.4e-20	45.4
WP_042510707.1\|43043_44219_+	hypothetical protein	A0A1B1P895	Bacillus_phage	6.0e-103	47.2
WP_165570320.1\|44215_44371_+	hypothetical protein	NA	NA	NA	NA
WP_042510708.1\|44682_45039_-	helix-turn-helix transcriptional regulator	A0A288WFW4	Bacillus_phage	2.8e-16	42.3
WP_000693792.1\|45231_45426_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_042510709.1\|45512_46283_+	phage antirepressor KilAC domain-containing protein	A0A075KK42	Lactobacillus_phage	2.9e-42	39.9
WP_172871170.1\|46395_46539_+	hypothetical protein	A0A1B1P8A8	Bacillus_phage	6.0e-18	95.7
WP_000655888.1\|46973_47123_+	hypothetical protein	A0A0M5M3T1	Bacillus_phage	1.8e-09	72.1
WP_042510710.1\|47135_47618_+	siphovirus Gp157 family protein	E5DV79	Deep-sea_thermophilic_phage	9.4e-39	51.9
WP_042510711.1\|47614_48310_+	ERF family protein	A0A2H4J7J4	uncultured_Caudovirales_phage	1.4e-38	50.4
WP_052495356.1\|48323_48974_+	hypothetical protein	A0A0C5K996	Enterococcus_phage	2.4e-37	41.1
WP_042510712.1\|48963_49146_+	hypothetical protein	A0A1B1P897	Bacillus_phage	7.2e-16	63.6
WP_042510714.1\|49367_50225_+	conserved phage C-terminal domain-containing protein	A0A1W6JP67	Staphylococcus_phage	7.1e-37	44.5
WP_042510715.1\|50148_50967_+	ATP-binding protein	A0A1B0T6C3	Bacillus_phage	1.1e-87	63.3
WP_042510716.1\|50970_51234_+	hypothetical protein	A0A1B1P8D7	Bacillus_phage	3.7e-21	79.3
WP_042510717.1\|51148_51436_+	hypothetical protein	A0A1B1P7W1	Bacillus_phage	3.5e-33	77.9
WP_042510718.1\|51432_51696_+	hypothetical protein	A0A0S2GLK4	Bacillus_phage	5.2e-23	61.4
WP_042510719.1\|51856_52216_-	cell division protein DivIVC	NA	NA	NA	NA
WP_042510720.1\|53081_53366_+	hypothetical protein	NA	NA	NA	NA
WP_042510721.1\|53514_53679_-	hypothetical protein	A0A288WGN0	Bacillus_phage	5.9e-09	51.9
WP_042510722.1\|54070_54700_+	Holliday junction resolvase RecU	A0A2H4J3A4	uncultured_Caudovirales_phage	2.0e-49	62.0
WP_042510723.1\|54839_55226_+	ArpU family transcriptional regulator	A0A1B1P853	Bacillus_phage	1.2e-44	75.0

Anti-CRISPR protein detection

Acr_ID: NZ_CP053933.1|WP_042510707.1|43043_44219_+|hypothetical-protein

Click the colored protein region to show detailed information

Acr_ID: NZ_CP053933.1|WP_165570320.1|44215_44371_+|hypothetical-protein

Click the colored protein region to show detailed information

Acr_ID: NZ_CP053933.1|WP_172871170.1|46395_46539_+|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_CP053933.1|WP_042510707.1|43043_44219_+|hypothetical-protein

43043_44219_+

391 aa aa

40497-55226

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP053934_1	Orphan	1.26\|438840\|20\|NZ_CP053934\|CRT	438840-438859	20	41421-41440	2

1. spacer 1.26|438840|20|NZ_CP053934|CRT matches to NZ_CP053933 position: 41421-41440, mismatch: 2

gcaacaggaagcacaggtcc	CRISPR spacer
gcaacaggaataacaggtcc	Protospacer
**********  ********

NZ_CP053933.1|WP_165570320.1|44215_44371_+|hypothetical-protein

44215_44371_+

51 aa aa

40497-55226

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP053934_1	Orphan	1.26\|438840\|20\|NZ_CP053934\|CRT	438840-438859	20	41421-41440	2

1. spacer 1.26|438840|20|NZ_CP053934|CRT matches to NZ_CP053933 position: 41421-41440, mismatch: 2

gcaacaggaagcacaggtcc	CRISPR spacer
gcaacaggaataacaggtcc	Protospacer
**********  ********

NZ_CP053933.1|WP_172871170.1|46395_46539_+|hypothetical-protein

46395_46539_+

47 aa aa

40497-55226

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP053934_1	Orphan	1.26\|438840\|20\|NZ_CP053934\|CRT	438840-438859	20	41421-41440	2

1. spacer 1.26|438840|20|NZ_CP053934|CRT matches to NZ_CP053933 position: 41421-41440, mismatch: 2

gcaacaggaagcacaggtcc	CRISPR spacer
gcaacaggaataacaggtcc	Protospacer
**********  ********

3. NZ_CP053934

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP053934_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053934_1

435512-438947

Orphan

Consensus_repeat	Method
AACNGGAANNACGGGNGCAACNGGA	CRT

27 spacers

The CRISPR arrays of NZ_CP053934_1

>merge|NZ_CP053934|1|435512-438947|CRT
AACGGGAAGTACGGGAGCGACGGGAACCACGGGAGCAACCGGAGAAACAGGTCCAACGGGAAGTACGGGAGCAACGGGAACCACGGGAGCAACCGGAGAAACAGGTCCAACGGGAACCACGGGAGCAACCGGAGAAACAGGTCCAACGGGAACCACGGGAGCAACCGGAGAAACAGGTCCAACGGGAAGTACGGGAGCAACGGGAACCACGGGAGCAACCGGAGAAACAGGTCCAACGGGAAGTACGGGAGCAATGGGAACCACGGGAGCAACAGGAGAAACAGGTCCAACGGGAAGTACGGGAGCAATGGGAACCACGGGAGCAACAGGAAGCACAGGTCCAACAGGAAGTACGGGTCCGACAGGAGAAACGGGATCGACAGGAAGTACGGGAGCAACGGGAACCACGGGAGCAACCGGAGAAACGGGAGCGACGGGGCCAACGGGAAGCATCGGAGCAATGGGAACCACGGGAGCAACAGGAGAAACAGGTCCAACGGGAAGTACGGGAGCAACAGGAAGTACTGGGGTAACAGGAAGTACGGGTCCAACAGGAGAAACGGGAGCAACCGGAAGTACGGGAGCAATCGGAAACACAGGTCCAACAGGAAGCACGGGAGAAACGGGAGTGACAGGAAGTACGGGTCCAACCGGAAACACGGGAGCAACAGGAAGTACTGGGGTAACAGGAAACACGGGTTCAACCGGAGCAACAGGTCCAACGGGAAACACGGGTCCAACAGGAAGCACCGGGGTAACCGGAAATACGGGAGCAACCGGAGCAATAGGTCCAACGGGAAGTACGGGTCCAACAGGAGAAACGGGAGTGACAGGAAGTACGGGTCCAACAGGAAATACGGGAGCGACGGGAAATACCGGTCCAACGGGAGAAACGGGAGTGACAGGTCCGACCGGAAGTACGGGAGTGACGGGAAGCACAGGTCCGACCGGAAGCACCGGAGCAACGGGAAACACTGGAGCAACCGGAGAAACAGGTCCAACGGGAAACACGGGAGTGACAGGAAGTACGGGTCCAACGGGAGAAACGGGAGTGACAGGAGGTACGGGTCCAACAGGAGAAACGGGAGTGACAGGAAGTACGGGTCCAACAGGAGAAACGGGAGTGACAGGAAGTACGGGTCCAACAGGAAGCACCGGGGTAACCGGAAATACGGGAGCAACCGGAGCAACAGGTCCAACGGGAAGTACGGGAGCAACGGGAAGTACGGGTCCAACGGGAGAAACGGGAGTGACAGGAAATACGGGTCCAACAGGAGAAACGGGAGTAACAGGAAGCACCGGGGTAACAGGAAATACGGGTCCAACAGGAAGCACCGGAGCAACGGGAAACACGGGTCCAACAGGAGAAACGGGAGCAACAGGAAGTACTGGGGTAACAGGAAGTACGGGAGCGACAGGAAACACGGGAGCAACGGGAAATACAGGAGCAACAGGAAGTACGGGTCCAACAGGAAATACGGGAGCGACGGGAAATACCGGTCCGACAGGAAACACGGGAGCAACAGGAGTAACAGGAAGCACCGGGGTAACAGGAAACACGGGTCCAACCGGAGAAACAGGTCCAACGGGAAGTACGGGGGCGACGGGAAATACCGGTCCAACAGGAGAAACGGGAGTGACAGGAAGTACGGGTCCAACAGGAAATACGGGAGCGACGGGAAATACCGGTCCGATAGGAGAAACGGGAGTGACAGGAAGTACGGGTTCAACGGGAGAAACGGGAGTGACAGGAAGTACGGGTTCAACCGGAAACACGGGTCCAACAGGAGAAACGGGAGTGACAGGAAGTACGGGTCCAACCGGAAACACGGGAGCAACAGGAAGTACGGGTCCGACAGGAGAAACGGGAGCAACGGGAAACACGGGTCCAACAGGAAGCACCGGGGTAACCGGAAATACGGGAGCAACCGGAGCAACAGGTCCAACGGGAAGTACGGGAGCAACCGGAGAAACGGGATCGACAGGAAACACGGGTCCAACAGGAAGCACCGGGGTAACCGGAAATACGGGAGCAACCGGAGAAACAGGTCCAACGGGAAGTACAGGGGCAACAGGAAGCACTGGGGTAACCGGAAATACGGGGGCAACAGGAAGCACCGGAGCAACGGGAAACACGGGTCCAACGGGAAGTACGGGAGAAACGGGAGCGACGGGAAATACCGGTCCAACGGGAGAAACGGGAGTGACAGGAAGTACGGGTCCAACCGGAAACACGGGAGCAACCGGAGAAACGGGAGTGACAGGTCCGACCGGAAGTACGGGAGTGACGGGAAGCACAGGTCCGACCGGAAGCACCGGAGCAACGGGAAACACGGGAGCAACCGGAGAAACAGGTCCAACCGGAAACACGGGAGTGACAGGAAGTACGGGTCCAACGGGAGAAACGGGAGTGACAGGAGGTACGGGTCCAACAGGAGAAACGGGAGTGACAGGAAGTACGGGTCCAACCGGAAGCACCGGGGTAACCGGAAATACGGGAGCAACCGGAGAAACAGGTCCAACGGGAAGTACGGGTCCAACGGGAGAAACGGGAGTGACAGGAAATACGGGTCCAACAGGAGAAACGGGAGTAACAGGAAGCACCGGGGTAACAGGAAATACGGGTCCAACAGGAAGCACCGGAGCAACGGGAAACACGGGTCCAACAGGAGAAACGGGAGCAACAGGAAGTACTGGGGTAACAGGAAGTACGGGAGCAACAGGAAGTACTGGGGTAACAGGAAGTACGGGAGCAACGGGAAATACAGGAGCAACAGGAAGTACGGGTCCAACAGGAAATACGGGAGCGACGGGAAATACGGGTCCAACAGGAGAAACGGGAGCGACAGGAAACACGGGAGCAACCGGAGAAACGGGAGTAACAGGAAGCACCGGGGTAACAGGAAATACGGGTCCAACAGGAAGCACCGGAGCAACGGGAAACACGGGTCCAACAGGAGAAACGGGAGCAACAGGAAGTACTGGGGTAACAGGAAGTACGGGAGCAACAGGAAGTACTGGGGTAACAGGAAGTACGGGAGCAACGGGAAATACAGGAGCAACAGGAAGTACGGGTCCAACAGGAAATACGGGAGCGACGGGAAGCACAGGTCCGACCGGAAGCACCGGAGCAACGGGAAACACGGGTCCAACCGGAGAAACAGGTCCAACGGGAAGTACGGGAGTAACAGGAAATACGGGAGCAACCGGAAGCACCGGGGTAACAGGAAACACGGGAGCAACAGGAGCAACAGGAAGCACCGGTCCAACGGGAAGTACGGGAGTGACAGGAAGTACAGGGGCAACAGGAAGCATCGGAGCAACGGGAGCAACAGGAAGCACAGGTCCAACAGGAAGCACCGGAGCAACGGGAGTAACGGGAAGTACAGGTCCGACCGGAAGCACCGGAACAACAGGAAATACGGGAGTAACAGGA

>NZ_CP053934|1|1|435512-438947|CRT
AACGGGAAGTACGGGAGCGACGGGA	ACCACGGGAGCAACCGGAGAAACAGGTCCAACGGGAAGTACGGGAGCAACGGGAACCACGGGAGCAACCGGAGAAACAGGTCCAACGGGAACCACGGGAGCAACCGGAGAAACAGGTCCAACGGGAACCACGGGAGCAACCGGAGAAACAGGTCC
AACGGGAAGTACGGGAGCAACGGGA	ACCACGGGAGCAACCGGAGAAACAGGTCCAACGGGAAGTACGGGAGCAATGGGAACCACGGGAGCAACAGGAGAAACAGGTCCAACGGGAAGTACGGGAGCAATGGGAACCACGGGAGCAACAGGAAGCACAGGTCCAACAGGAAGTACGGGTCCGACAGGAGAAACGGGATC
GACAGGAAGTACGGGAGCAACGGGA	ACCACGGGAGCAACCGGAGAAACGGGAGCGACGGGGCCAACGGGAAGCATCGGAGCAATGGGAACCACGGGAGCAACAGGAGAAACAGGTCCAACGGGAAGTACGGGAGCAACAGGAAGTACTGGGGTAACAGGAAGTACGGGTCCAACAGGAGAAACGGGAGC
AACCGGAAGTACGGGAGCAATCGGA	AACACAGGTCCAACAGGAAGCACGGGAGAAACGGGAGTGACAGGAAGTACGGGTCCAACCGGAAACACGGGAGCAACAGGAAGTACTGGGGTAACAGGAAACACGGGTTCAACCGGAGCAACAGGTCCAACGGGAAACACGGGTCCAACAGGAAGCACCGGGGT
AACCGGAAATACGGGAGCAACCGGA	GCAATAGGTCCAACGGGAAGTACGGGTCCAACAGGAGAAACGGGAGTGACAGGAAGTACGGGTCCAACAGGAAATACGGGAGCGACGGGAAATACCGGTCCAACGGGAGAAACGGGAGTGACAGGTCCGACCGGAAGTACGGGAGTGACGGGAAGCACAGGTCCGACCGGAAGCACCGGAGC
AACGGGAAACACTGGAGCAACCGGA	GAAACAGGTCCAACGGGAAACACGGGAGTGACAGGAAGTACGGGTCCAACGGGAGAAACGGGAGTGACAGGAGGTACGGGTCCAACAGGAGAAACGGGAGTGACAGGAAGTACGGGTCCAACAGGAGAAACGGGAGTGACAGGAAGTACGGGTCCAACAGGAAGCACCGGGGT
AACCGGAAATACGGGAGCAACCGGA	GCAACAGGTCCAACGGGAAGTACGGGAGCAACGGGAAGTACGGGTCCAACGGGAGAAACGGGAGTGACAGGAAATACGGGTCCAACAGGAGAAACGGGAGTAACAGGAAGCACCGGGGTAACAGGAAATACGGGTCCAACAGGAAGCACCGGAGC
AACGGGAAACACGGGTCCAACAGGA	GAAACGGGAGCAACAGGAAGTACTGGGGTAACAGGAAGTACGGGAGCGACAGGAAACACGGGAGCAACGGGAAATACAGGAGCAACAGGAAGTACGGGTCCAACAGGAAATACGGGAGCGACGGGAAATACCGGTCC
GACAGGAAACACGGGAGCAACAGGA	GTAACAGGAAGCACCGGGGTAACAGGAAACACGGGTCCAACCGGAGAAACAGGTCCAACGGGAAGTACGGGGGCGACGGGAAATACCGGTCCAACAGGAGAAACGGGAGTGACAGGAAGTACGGGTCC
AACAGGAAATACGGGAGCGACGGGA	AATACCGGTCCGATAGGAGAAACGGGAGTGACAGGAAGTACGGGTTCAACGGGAGAAACGGGAGTGACAGGAAGTACGGGTTCAACCGGAAACACGGGTCCAACAGGAGAAACGGGAGTGACAGGAAGTACGGGTCC
AACCGGAAACACGGGAGCAACAGGA	AGTACGGGTCCGACAGGAGAAACGGGAGCAACGGGAAACACGGGTCCAACAGGAAGCACCGGGGTAACCGGAAATACGGGAGCAACCGGAGCAACAGGTCC
AACGGGAAGTACGGGAGCAACCGGA	GAAACGGGATCGACAGGAAACACGGGTCCAACAGGAAGCACCGGGGTAACCGGAAATACGGGAGCAACCGGAGAAACAGGTCCAACGGGAAGTACAGGGGCAACAGGAAGCACTGGGGT
AACCGGAAATACGGGGGCAACAGGA	AGCACCGGAGCAACGGGAAACACGGGTCCAACGGGAAGTACGGGAGAAACGGGAGCGACGGGAAATACCGGTCCAACGGGAGAAACGGGAGTGACAGGAAGTACGGGTCC
AACCGGAAACACGGGAGCAACCGGA	GAAACGGGAGTGACAGGTCCGACCGGAAGTACGGGAGTGACGGGAAGCACAGGTCCGACCGGAAGCACCGGAGCAACGGGAAACACGGGAGCAACCGGAGAAACAGGTCC
AACCGGAAACACGGGAGTGACAGGA	AGTACGGGTCCAACGGGAGAAACGGGAGTGACAGGAGGTACGGGTCCAACAGGAGAAACGGGAGTGACAGGAAGTACGGGTCCAACCGGAAGCACCGGGGT
AACCGGAAATACGGGAGCAACCGGA	GAAACAGGTCCAACGGGAAGTACGGGTCCAACGGGAGAAACGGGAGTGACAGGAAATACGGGTCCAACAGGAGAAACGGGAGTAACAGGAAGCACCGGGGT
AACAGGAAATACGGGTCCAACAGGA	AGCACCGGAGCAACGGGAAACACGGGTCCAACAGGAGAAACGGGAGCAACAGGAAGTACTGGGGT
AACAGGAAGTACGGGAGCAACAGGA	AGTACTGGGGTAACAGGAAGTACGGGAGCAACGGGAAATACAGGAGCAACAGGAAGTACGGGTCCAACAGGAAATACGGGAGC
GACGGGAAATACGGGTCCAACAGGA	GAAACGGGAGCGACAGGAAACACGGGAGCAACCGGAGAAACGGGAGTAACAGGAAGCACCGGGGT
AACAGGAAATACGGGTCCAACAGGA	AGCACCGGAGCAACGGGAAACACGGGTCCAACAGGAGAAACGGGAGCAACAGGAAGTACTGGGGT
AACAGGAAGTACGGGAGCAACAGGA	AGTACTGGGGTAACAGGAAGTACGGGAGCAACGGGAAATACAGGAGC
AACAGGAAGTACGGGTCCAACAGGA	AATACGGGAGCGACGGGAAGCACAGGTCCGACCGGAAGCACCGGAGC
AACGGGAAACACGGGTCCAACCGGA	GAAACAGGTCCAACGGGAAGTACGGGAGTAACAGGAAATACGGGAGC
AACCGGAAGCACCGGGGTAACAGGA	AACACGGGAGCAACAGGAGC
AACAGGAAGCACCGGTCCAACGGGA	AGTACGGGAGTGACAGGAAGTACAGGGGC
AACAGGAAGCATCGGAGCAACGGGA	GCAACAGGAAGCACAGGTCC
AACAGGAAGCACCGGAGCAACGGGA	GTAACGGGAAGTACAGGTCCGACCGGAAGCACCGGAAC
AACAGGAAATACGGGAGTAACAGGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053934.1\|WP_000180554.1\|427301_427724_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|212152
NZ_CP053934.1\|WP_000049060.1\|429244_430339_-\|GerAB/ArcD/ProY-family-transporter	unknown	unknown	gnl\|CDD\|281794
NZ_CP053934.1\|WP_000141219.1\|434270_434576_+\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
NZ_CP053934.1\|WP_001110865.1\|434898_435222_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053934.1\|WP_000286667.1\|446104_446890_+\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|181585
NZ_CP053934.1\|WP_000411386.1\|428189_429269_-\|spore-germination-protein-GerHC	unknown	unknown	gnl\|CDD\|274338
NZ_CP053934.1\|WP_000512460.1\|434653_434878_+\|spore-germination-protein	unknown	unknown	gnl\|CDD\|371190
NZ_CP053934.1\|WP_000094141.1\|441643_442129_-\|cyclic-pyranopterin-monophosphate-synthase-MoaC	unknown	unknown	gnl\|CDD\|236483
NZ_CP053934.1\|WP_000350858.1\|445233_446091_+\|glucose-uptake-protein-GlcU	unknown	unknown	gnl\|CDD\|227309
NZ_CP053934.1\|WP_000621794.1\|444450_444684_+\|molybdopterin-converting-factor-subunit-1	unknown	unknown	gnl\|CDD\|340452
NZ_CP053934.1\|WP_001982690.1\|444777_445197_+\|DUF3888-domain-containing-protein	unknown	unknown	gnl\|CDD\|379024
NZ_CP053934.1\|WP_000185938.1\|443983_444448_+\|molybdopterin-synthase-catalytic-subunit-MoaE	unknown	unknown	gnl\|CDD\|223391
NZ_CP053934.1\|WP_001167649.1\|432713_433838_+\|homoserine-O-acetyltransferase	unknown	unknown	gnl\|CDD\|235859
NZ_CP053934.1\|WP_000229682.1\|442212_443502_+\|molybdopterin-molybdotransferase-MoeA	unknown	unknown	gnl\|CDD\|238452
NZ_CP053934.1\|WP_038357118.1\|443465_443987_+\|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	unknown	unknown	gnl\|CDD\|349770
NZ_CP053934.1\|WP_000038782.1\|427913_428099_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053934.1\|WP_172871171.1\|430356_432561_-\|spore-germination-protein	unknown	unknown	gnl\|CDD\|377020
NZ_CP053934.1\|WP_000171893.1\|433887_434070_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053934.1\|WP_001158086.1\|440591_441605_+\|molybdopterin-synthase-adenylyltransferase-MoeB	unknown	unknown	gnl\|CDD\|183547
NZ_CP053934.1\|WP_001157133.1\|439561_440575_+\|GTP-3',8-cyclase-MoaA	unknown	unknown	gnl\|CDD\|274250

Protein	Function_ID	Function_description	E-value
NZ_CP053934.1\|WP_000180554.1\|427301_427724_-\|hypothetical-protein	gnl\|CDD\|212152	cd11545, NTP-PPase_YP_001813558, Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs. This family contains a putative NTP_PPase (YP_001813558.1) from Exiguobacterium sibiricum and its bacterial homologs. Unlike normal dimeric dUTPase-like proteins with a central four-helix bundle forming the active site, YP_001813558.1 displays a very unusual interlaced segment-swapped dimer that might be important for it to adapt to an extremely cold environment. Moreover, structural analysis and comparisons indicate that YP_001813558.1 potentially prefers to hydrolyze dCTPs or its derivatives.	1.24419e-63
NZ_CP053934.1\|WP_000049060.1\|429244_430339_-\|GerAB/ArcD/ProY-family-transporter	gnl\|CDD\|281794	pfam03845, Spore_permease, Spore germination protein.	4.92966e-92
NZ_CP053934.1\|WP_001157133.1\|439561_440575_+\|GTP-3',8-cyclase-MoaA	gnl\|CDD\|274250	TIGR02666, Cyclic_pyranopterin_monophosphate_synthase, molybdenum cofactor biosynthesis protein A, bacterial. The model for this family describes molybdenum cofactor biosynthesis protein A, or MoaA, as found in bacteria. It does not include the family of probable functional equivalent proteins from the archaea. MoaA works together with MoaC to synthesize precursor Z from guanine. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin].	1.21516e-152
NZ_CP053934.1\|WP_000141219.1\|434270_434576_+\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	5.00074e-23
NZ_CP053934.1\|WP_000512460.1\|434653_434878_+\|spore-germination-protein	gnl\|CDD\|371190	pfam10676, gerPA, Spore germination protein gerPA/gerPF. This is a bacterial family of proteins that are required for the formation of functionally normal spores. Proteins in this family may be involved in establishing normal coat structure and/or permeability which could control the access of germinants to their receptor.	1.96238e-13
NZ_CP053934.1\|WP_000094141.1\|441643_442129_-\|cyclic-pyranopterin-monophosphate-synthase-MoaC	gnl\|CDD\|236483	PRK09364, moaC, cyclic pyranopterin monophosphate synthase MoaC.	2.81096e-97
NZ_CP053934.1\|WP_000350858.1\|445233_446091_+\|glucose-uptake-protein-GlcU	gnl\|CDD\|227309	COG4975, GlcU, Putative glucose uptake permease [Carbohydrate transport and metabolism].	1.17813e-118
NZ_CP053934.1\|WP_000621794.1\|444450_444684_+\|molybdopterin-converting-factor-subunit-1	gnl\|CDD\|340452	cd00754, Ubl_MoaD, ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and similar proteins. MoaD, also termed molybdopterin synthase sulfur carrier subunit, or MPT synthase subunit 1, or MPT synthase small subunit, or molybdopterin-converting factor small subunit, or molybdopterin-converting factor subunit 1, is a conserved small sulfur carrier protein that has beta-grasp ubiquitin-like (Ubl) fold involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor of a diverse group of redox enzymes. MoaD is activated in an ATP-dependent manner by sulfurtransferases similar to the activation mechanism of ubiquitin-activating enzyme E1.	3.20312e-19
NZ_CP053934.1\|WP_001982690.1\|444777_445197_+\|DUF3888-domain-containing-protein	gnl\|CDD\|379024	pfam13027, DUF3888, Protein of unknown function (DUF3888). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 111 and 149 amino acids in length.	7.26816e-07
NZ_CP053934.1\|WP_000185938.1\|443983_444448_+\|molybdopterin-synthase-catalytic-subunit-MoaE	gnl\|CDD\|223391	COG0314, MoaE, Molybdopterin converting factor, large subunit [Coenzyme metabolism].	3.31126e-56
NZ_CP053934.1\|WP_001167649.1\|432713_433838_+\|homoserine-O-acetyltransferase	gnl\|CDD\|235859	PRK06765, PRK06765, homoserine O-acetyltransferase; Provisional.	0
NZ_CP053934.1\|WP_000229682.1\|442212_443502_+\|molybdopterin-molybdotransferase-MoeA	gnl\|CDD\|238452	cd00887, MoeA, MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.	7.27051e-162
NZ_CP053934.1\|WP_038357118.1\|443465_443987_+\|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	gnl\|CDD\|349770	cd03116, MobB, molybdopterin-guanine dinucleotide biosynthesis protein B. Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In Escherichia coli, the synthesis of Moco involves genes from several loci: moa, mob, mod, moe and mog. The mob locus contains mobA and mobB genes. MobB catalyzes the attachment of the guanine dinucleotide to molybdopterin.	6.37325e-42
NZ_CP053934.1\|WP_000286667.1\|446104_446890_+\|glucose-1-dehydrogenase	gnl\|CDD\|181585	PRK08936, PRK08936, glucose-1-dehydrogenase; Provisional.	0
NZ_CP053934.1\|WP_172871171.1\|430356_432561_-\|spore-germination-protein	gnl\|CDD\|377020	pfam03323, GerA, Bacillus/Clostridium GerA spore germination protein.	0
NZ_CP053934.1\|WP_001158086.1\|440591_441605_+\|molybdopterin-synthase-adenylyltransferase-MoeB	gnl\|CDD\|183547	PRK12475, PRK12475, thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional.	0
NZ_CP053934.1\|WP_000411386.1\|428189_429269_-\|spore-germination-protein-GerHC	gnl\|CDD\|274338	TIGR02887, Spore_germination_protein_B3, germination protein, Ger(x)C family. Members of this protein family are restricted to endospore-forming members of the Firmicutes lineage of bacteria, including the genera Bacillus, Clostridium, Thermoanaerobacter, Carboxydothermus, etc. Members are nearly all predicted lipoproteins and belong to probable transport operons, some of which have been characterized as crucial to germination in response to alanine. Members typically have been gene symbols gerKC, gerAC, gerYC, etc. [Transport and binding proteins, Amino acids, peptides and amines, Cellular processes, Sporulation and germination].	6.56693e-101

>NZ_CP053934.1|WP_001110865.1|434898_435222_+|hypothetical-protein
MPAHIKEFVIVNNTGNIFTGDNLSDTSFTATKSYSGSMGCTWIDVVTVIGTETKLCLQPGDSVTTTYTRGTPAGTVTGTNMGQSVNTSGIAQAVPNTDNMDSTAGLP
>NZ_CP053934.1|WP_000512460.1|434653_434878_+|spore-germination-protein
MGINLRKVKIINNIGAVNVGDCYDISPLAVAKVYAGAGGSSAAIFLNGKRQPEAVIRTSVFLPPLATSTRTLGS
>NZ_CP053934.1|WP_000141219.1|434270_434576_+|rhodanese-like-domain-containing-protein
MTEVKTITTEEVQERLENGETLFLVDVREDEEVATGKIPEAVHIKMGDIPNKVDFFDKENEYIFICRSGMRSENVCHYLNEQGFKTVNMVGGMLQYEGEIK
>NZ_CP053934.1|WP_000171893.1|433887_434070_-|hypothetical-protein
MTLFLFIMSIVFLLAAIIALSMKNNKKIKSPQEMSFLFLLLSIAFFGIAIATYIFRLQIM
>NZ_CP053934.1|WP_001167649.1|432713_433838_+|homoserine-O-acetyltransferase
MQIVKKENFILKEFTFENGREIPVQMGYETYGTLNRERSNAILVCHYFSATSHAAGKYTAHDEESGWWDGLIGPGKAIDTNKYFVICADNLCNVQVKNTYVITTGPKSINPKTGDEYAMDFPVFTFLDVARMQYELIKDMGIPRLYAVMGPSAGGMIAQQWAVHYPHMVERMIGVITNPQNPIITSVNVAQNAIEAIRLDPSWKSGKYGEEQPMKGLQLANRMMFMNAFDEHFYETTFPRNSIEVEPYEKVSSLTSFEKEINKLIYRSIELVDANSWMYTAKAVLLHDIAHGFSSLEEALSNVEANVLMIPCKQDLLQPSRYNYKMVDLLQKQGKYAEVYEIESINGHMAGVFDIHLFEKKVYEFLNRKVSSFV
>NZ_CP053934.1|WP_172871171.1|430356_432561_-|spore-germination-protein
MIWNWLRKKKKSNTTEKNETDNSEQKPNNQEDDNKEQTRSTKHNKGNNSEQKKEEHKESSQDKQQNQSNQNQQQSAKQDESSQEQQNHSKQNDSDQGQQQHSKQDDSNQGQQQHSKQDDSNQGQQNHSKQDDSNQGQQNHSKQNDSDQGQQQHSKQDDSNQGQQNHSKQNDSDQGQQQHSKQDDSNQGQQNHSKQDHSDQDDSSQDKQQSSKQDDLAQDKQQHSKQDNSDQDKQQNSKGNSIYDFSKPEKDRIHSLQDLIEKLKKSSDFVNYHTSDDETMPYWISYYRPSLDGEKLQKYLMPTLLERPNASLEELKEHIPMSGITITNDLQKIEDMVLKGHAIVQVNQQDQKCMLANIAIDNYRAPTPPLNESTVIGPQEGFVEDIDTNINLVRKRLPVLDLQTKEMIVGEFSKTKVVMMYLDNLAEKDNVDFLEESLRALEYDQINDSAYIQELMGEKSIFPLYINTERTDRVTKALIDGKIAIFVDGSPSVLLTPVSYFDFFISPEDYNVSWLYATFSRILRLIAVLFSICATPLYVAVLNYHYELIPSDLLETLILSRAQVPFPPLIEALFLELAIDLLREAGARLPMKVGQTLGIVGGIVIGQASVQAGLTSNILLIIVALSALASFITPIYKMGNAVRLLRFPFLIFAEIGGLFGISLGFIFLFTHLFRLTSLRKPYALFYPTRQQSVKDSWIRFPLTMIDTRDVQARPQHVKKSAKGISTKHRSDFDD
>NZ_CP053934.1|WP_000049060.1|429244_430339_-|GerAB/ArcD/ProY-family-transporter
MSKVQEKYQISPIFVFFLIHGAQFGAGVLGFARIIAKAAGYDGWMGVLITGLCIHLLIWMMYFLLKETNGNLIDLQRQTFGKWIGNVFNIIFAAYFLIVSISVIRTYVEIIQVWMFPTASTFMLTLFLCLVSYYIISSGFRVITGICVISVGGTIGYLFLSLFVLKYSHWDNLLPIFTHSFSDILKSAQLSIYSMTGFEIYLMVYPFVKKPMQSHKYAQLGALFSNLLYLFSTLLAFAFFSEKQLLKTIWAQLSMTQVIQLPFIERLEYIAISGYALVIISSFILPLWASMRATHEIFRVKQRGILIAFIIITLIVSQLLTNRQDINNFISNASKVSFWLIYVYIPILFIIVWVKRKWKKSKAN
>NZ_CP053934.1|WP_000411386.1|428189_429269_-|spore-germination-protein-GerHC
MEKIKSKLVLISCIALFSLTGCLQKNIIDDVQLIQGTVFDTAKDNKVKVTFVCPIQKKGNKVQVFEGTANAVKQVKADTSLESSQPFASGQMRVALYTIRLAKKGMSTSFDTLLRDVNIGNALYAALLDGNGTELLKGKYSTSYNVAIYIKKLLEHNMETGPLPADNLHIGAFRYYQEGQDYYIPILKKHGDKIKITGIGLFKKDKYIGKIAEKDMFIFKGLLEKHKLDSHEFKTDSAYVMINNIRSVPTYDIKIKNGKPSFFIHVRLDARIQELSKQINLENNKNTKNIEKDVQKQLDKQAAKLIKHLKSLGVDPLGLGAKYKQHYRPFKLEEWRQMYKDVPVTIKYTVNITNSGVIE
>NZ_CP053934.1|WP_000038782.1|427913_428099_-|hypothetical-protein
MSKKLVKPILNGILFLGVFLFAHTYLKNVSFTRYLLVVIPMLLVGMFGIDLILSILIKEEK
>NZ_CP053934.1|WP_000180554.1|427301_427724_-|hypothetical-protein
MTNEKGLDKGYELVAKMHEVFGHPVTNTPTKLTEERAKIRASFMQEELEEFLEATTVEDQYDALIDLIYFAFGTFAEMGVRPDKGFEIVNNANMAKLFPDGKPRFREGDGKILKPEGWQAPEPQLRAEIERQRQEAEKNC
>NZ_CP053934.1|WP_001157133.1|439561_440575_+|GTP-3',8-cyclase-MoaA
MQEMVTDFFERPLQDLRISVIDRCNFRCTYCMPAEVFGPDYAFLKDEFLLTFDEIERVAKLFVSIGVRKIRLTGGEPLLRKDLAKLIARLVKIDGLLDIGLTTNAIHLTKQAKVLKEAGLHRVNVSLDAIDDDVFKAINGRNINTKPVIKGIMAAKEAGLDVKVNMVVKKGMNDHQVLPMATYFKEQGIPLRFIEFMDVGSTNGWNFDQVVTKRELIEMIHRVYPLEPAEAHYFGEVAKRYRYVGTNIEVGFITSVSESFCSSCTRARISADGKFYTCLFATEGVDIRELLRAKLSDDELLSVIQDVWMNRKDRYSDERTEESAKNRPKIEMSYIGG
>NZ_CP053934.1|WP_001158086.1|440591_441605_+|molybdopterin-synthase-adenylyltransferase-MoeB
MQERYSRQILFSGVGEEGQRKIREKHVLIIGAGALGAANAEAIVRAGVGKITIADRDYVEWSNLQRQQLYTEEDAKQYKPKAVAAAEHLKAINSEVEINPVVTDVTVQEMEELVKDVDLILDATDNFETRLLINDISQKYNIPWIYGGCVGSYGVTYTIVPGKTPCFRCLMEHPASGATCDTAGIIQPAVQLVVAHQITEALKILVEDFEALRETMLSFDLWNNQQMAFKVNRQKKDTCLSCGRLRTYPSLTFEAQTKTEVLCGRNTVQIRPGVRNEFNLEEIKKRLQRSVDVKATPYLVSFLVEEFRFVLFTDGRAFIHGTNDINVAKRLYTRYIG
>NZ_CP053934.1|WP_000094141.1|441643_442129_-|cyclic-pyranopterin-monophosphate-synthase-MoaC
MSSFTHFNDQGRAKMVDISDKKATVRTAIACSSIVVTKEIYDKISHNEIGKGDVLAVAQIAGIMAAKRTSDIIPMCHPLLLKGVDVSFDWKQSDEQYRLLIEVKVKTEGSTGVEMEALTAASATALTVYDMCKAVDKGMIIGETYLLEKTGGKSGDYTRKS
>NZ_CP053934.1|WP_000229682.1|442212_443502_+|molybdopterin-molybdotransferase-MoeA
MVEKRIPIQVAEAVERVMEYAKIGEVEEVSITESYGRILGEDVVSDHDVPHFDRSPYDGFAIRAEDTKEANQENAIEFEVIGEIGAGSVFTEEVGSFQAVRIMTGAAIPADCNAVVMLELTEGFEKNGKTYMKLKRPFHSGDNVSFKGEDIKQNQVLVKKGAVINPGVAALLATFGYSNVKVVKQPVVGIVTTGSELLEVHESLQPGKIRNSNSYMIAAQIMKAGGKVRYYGQLADELDACFTAVQSAIEEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVDGKLLFGLSGNPSACYVGFELFVHPVIKTYLYAKEPHVYRADAILQKDFPKPNPFTRFVRAKVTIVDGALHAMPVGLDKSSAVSSLADANAFIVLPGGTRGFETGMKVSVLLLEHAEGCDWPWAKPLQSYK
>NZ_CP053934.1|WP_038357118.1|443465_443987_+|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B
MAVGKAPSILQIVGYQNSGKTTLVEKIVHVLTESEMKVATIKHHGHGGFPEVAQKDSERHRKAGAIVSSVEGAGLLSLSSLREEWSLQEIIRLYEFFEVDTILIEGYKQESYPKVVLLRSAEDVELLHKVENIVAVITWYDAPANLREEYKVFHITEDELYIDWFLQTVRSAK
>NZ_CP053934.1|WP_000185938.1|443983_444448_+|molybdopterin-synthase-catalytic-subunit-MoaE
MTNTYYEVIDTEISIEEVAKRVIRRECGAVTTFIGTVREFTKGRRTLYLEYVAYKTMAEKMLEKIGSEVKGKWPGTHVAITHRIGTLQISDIAVVVAVSTPHRKAAYEANEYIMERIKQIVPIWKKEFWEDGDSWIGDQLEKTPYPAGEPGKEL
>NZ_CP053934.1|WP_000621794.1|444450_444684_+|molybdopterin-converting-factor-subunit-1
MIRVLLFANLQEEAGRSELQIEKESITVAELKDVVAKEYNVPVTEPIMVAINEEYANEEDTIQSGDVVALIPPVSGG
>NZ_CP053934.1|WP_001982690.1|444777_445197_+|DUF3888-domain-containing-protein
MKKLCVMLTMICSIFFFFPSYSLAKESNEQLLESALLNRYYSVIRQVTEDQYECASVINIKRLGKNGEFVPRYEVTLQFLTFQGAHNPPNDKVTLTLEDYLDHVRIKKVEREKNVSGALAEKICEREKEKIKAHSTDSE
>NZ_CP053934.1|WP_000350858.1|445233_446091_+|glucose-uptake-protein-GlcU
MDIFLAILPAIFWGSIVLFNVKLGGGPYSQTLGTTFGALIFSIVVYIFMKPVLTPTVIGVGIVSGLFWALGQANQLKSIDLMGVSRTMPISTGLQLVSTTLFGVIVFHEWSTTISVVLGVLALVCIIIGVILTSLQSEEEKNAEQAGNFKRGIIILLISTVGYLVYVVVIRLFNVDGWSALLPQAVGMVLGGILLTFKHHPFNKYAIRNIIPGLIWAAGNMFLFISQPRVGVATSFSLSQMGIIISTLGGILILGERKTKRQLTGIVVGIVFIIAAGIMLGIAKS
>NZ_CP053934.1|WP_000286667.1|446104_446890_+|glucose-1-dehydrogenase
MYSDLAGKVVVITGSATGLGRAMGVRFAKEKAKVVINYRSRESEAHDVLEEIKKVGGEAIAVKGDVTVESDVVNLIQSAVKEFGTLDVMINNAGIENAVPSHEMPLEDWNKVINTNLTGAFLGSREAIKYFVEHDIKGSIINMSSVHEKIPWPLFVHYAASKGGMKLMTETLAMEYAPKGIRVNNIGPGAINTPINAEKFADPKKRADVESMIPMGYIGKPEEIAAVATWLASSEASYVTGITLFADGGMTLYPSFQAGRG

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Crispr_ID: NZ_CP053934_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053934_2

1658705-1658806

Orphan

Consensus_repeat	Method
ACATTCTCAAAAGAAACCTAAATT	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP053934_2

>merge|NZ_CP053934|2|1658705-1658806|CRISPRCasFinder
ACATTCTCAAAAGAAACCTAAATTGTCAAGGAAGGAAAGGAGACAATCCACGGCTACTTCGGGGCATGTAAATATACCACATTCTCAAAAGAAACCTAAACT

>NZ_CP053934|2|1|1658705-1658806|CRISPRCasFinder
ACATTCTCAAAAGAAACCTAAATT	GTCAAGGAAGGAAAGGAGACAATCCACGGCTACTTCGGGGCATGTAAATATACC
ACATTCTCAAAAGAAACCTAAACT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053934.1\|WP_000129215.1\|1667472_1668264_-\|arylamine-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366312
NZ_CP053934.1\|WP_000915215.1\|1664399_1665533_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP053934.1\|WP_042510987.1\|1651561_1653028_-\|YdiU-family-protein	unknown	unknown	gnl\|CDD\|234583
NZ_CP053934.1\|WP_000351706.1\|1661631_1662483_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176133
NZ_CP053934.1\|WP_000417237.1\|1657411_1658065_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053934.1\|WP_000933354.1\|1657133_1657307_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053934.1\|WP_000544596.1\|1661129_1661639_-\|DUF3916-domain-containing-protein	unknown	unknown	gnl\|CDD\|372464
NZ_CP053934.1\|WP_001102724.1\|1650212_1651307_-\|RapH-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|376220
NZ_CP053934.1\|WP_000571882.1\|1654314_1654719_-\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP053934.1\|WP_001172053.1\|1648321_1648669_+\|DUF4260-domain-containing-protein	unknown	unknown	gnl\|CDD\|379455
NZ_CP053934.1\|WP_000137564.1\|1665568_1667356_-\|oligoendopeptidase-F	unknown	unknown	gnl\|CDD\|341071
NZ_CP053934.1\|WP_001226323.1\|1659369_1660314_+\|glycerophosphodiester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176543
NZ_CP053934.1\|WP_000473534.1\|1668479_1670021_+\|alpha-amylase	unknown	unknown	gnl\|CDD\|236518
NZ_CP053934.1\|WP_000592015.1\|1650027_1650216_-\|Phr-family-secreted-Rap-phosphatase-inhibitor	unknown	unknown	gnl\|CDD\|275222
NZ_CP053934.1\|WP_000236550.1\|1660358_1661036_-\|YdcF-family-protein	unknown	unknown	gnl\|CDD\|99750
NZ_CP053934.1\|WP_000646398.1\|1653206_1654205_-\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176191
NZ_CP053934.1\|WP_002036901.1\|1662568_1663813_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341028
NZ_CP053934.1\|WP_042510988.1\|1655186_1656806_+\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|366675
NZ_CP053934.1\|WP_000275806.1\|1649354_1649954_+\|protease-synthase/sporulation-negative-transcriptional-regulator-PaiB	unknown	unknown	gnl\|CDD\|377290
NZ_CP053934.1\|WP_000798800.1\|1663912_1664143_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP053934.1\|WP_000129215.1\|1667472_1668264_-\|arylamine-N-acetyltransferase	gnl\|CDD\|366312	pfam00797, Acetyltransf_2, N-acetyltransferase. Arylamine N-acetyltransferase (NAT) is a cytosolic enzyme of approximately 30kDa. It facilitates the transfer of an acetyl group from Acetyl Coenzyme A on to a wide range of arylamine, N-hydroxyarylamines and hydrazines. Acetylation of these compounds generally results in inactivation. NAT is found in many species from Mycobacteria (M. tuberculosis, M. smegmatis etc) to man. It was the first enzyme to be observed to have polymorphic activity amongst human individuals. NAT is responsible for the inactivation of Isoniazid (a drug used to treat Tuberculosis) in humans. The NAT protein has also been shown to be involved in the breakdown of folic acid.	3.61808e-48
NZ_CP053934.1\|WP_000915215.1\|1664399_1665533_+\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.16238e-58
NZ_CP053934.1\|WP_042510987.1\|1651561_1653028_-\|YdiU-family-protein	gnl\|CDD\|234583	PRK00029, PRK00029, YdiU family protein.	0
NZ_CP053934.1\|WP_000351706.1\|1661631_1662483_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176133	cd08442, PBP2_YofA_SoxR_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold. YofA is a LysR-like transcriptional regulator of cell growth in Bacillus subtillis. YofA controls cell viability and the formation of constrictions during cell division. YofaA positively regulates expression of the cell division gene ftsW, and thus is essential for cell viability during stationary-phase growth of Bacillus substilis. YofA shows significant homology to SoxR from Arthrobacter sp. TE1826. SoxR is a negative regulator for the sarcosine oxidase gene soxA. Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine, which is involved in the metabolism of creatine and choline. The topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.50852e-87
NZ_CP053934.1\|WP_000137564.1\|1665568_1667356_-\|oligoendopeptidase-F	gnl\|CDD\|341071	cd09608, M3B_PepF, Peptidase family M3B, oligopeptidase F (PepF). Peptidase family M3B oligopeptidase F (PepF; Pz-peptidase B; EC 3.4.24.-) is mostly bacterial and includes oligoendopeptidase F from Lactococcus lactis. This enzyme hydrolyzes peptides containing between 7 and 17 amino acids with fairly broad specificity. The PepF gene is duplicated in L. lactis on the plasmid that bears it, while a shortened second copy is found in Bacillus subtilis. Most bacterial PepFs are cytoplasmic endopeptidases; however, the Bacillus amyloliquefaciens PepF oligopeptidase is a secreted protein and may facilitate the process of sporulation. Specifically, the yjbG gene encoding the homolog of the PepF1 and PepF2 oligoendopeptidases of Lactococcus lactis has been identified in Bacillus subtilis as an inhibitor of sporulation initiation when over-expressed from a multicopy plasmid. This PepF family includes Streptococcus agalactiae PepB, a group B streptococcal oligopeptidase which has been shown to degrade a variety of bioactive peptides as well as the synthetic collagen-like substrate N-(3-[2-furyl]acryloyl)-Leu-Gly- Pro-Ala in vitro.	0
NZ_CP053934.1\|WP_000544596.1\|1661129_1661639_-\|DUF3916-domain-containing-protein	gnl\|CDD\|372464	pfam13079, DUF3916, Protein of unknown function (DUF3916). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 170 amino acids in length. There is a single completely conserved residue S that may be functionally important.	1.96654e-76
NZ_CP053934.1\|WP_001102724.1\|1650212_1651307_-\|RapH-N-terminal-domain-containing-protein	gnl\|CDD\|376220	pfam18801, RapH_N, response regulator aspartate phosphatase H, N terminal. Rap proteins consist of a N-terminal 3-helix bundle and a tetratricopeptide domain. This entry represents the conserved region of the C-terminal bundle.	4.37294e-18
NZ_CP053934.1\|WP_000571882.1\|1654314_1654719_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	3.50044e-15
NZ_CP053934.1\|WP_001172053.1\|1648321_1648669_+\|DUF4260-domain-containing-protein	gnl\|CDD\|379455	pfam14079, DUF4260, Domain of unknown function (DUF4260). This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 114 and 126 amino acids in length. There is a conserved GLK sequence motif.	2.33749e-49
NZ_CP053934.1\|WP_001226323.1\|1659369_1660314_+\|glycerophosphodiester-phosphodiesterase	gnl\|CDD\|176543	cd08601, GDPD_SaGlpQ_like, Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in uncharacterized glycerophosphodiester phosphodiesterase (GP-GDE, EC 3.1.4.46) from Staphylococcus aureus, Bacillus subtilis and similar proteins. Members in this family show very high sequence similarity to Escherichia coli periplasmic phosphodiesterase GlpQ, which catalyzes the Ca2+-dependent degradation of periplasmic glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.	1.4382e-149
NZ_CP053934.1\|WP_000473534.1\|1668479_1670021_+\|alpha-amylase	gnl\|CDD\|236518	PRK09441, PRK09441, cytoplasmic alpha-amylase; Reviewed.	0
NZ_CP053934.1\|WP_000592015.1\|1650027_1650216_-\|Phr-family-secreted-Rap-phosphatase-inhibitor	gnl\|CDD\|275222	TIGR04429, hypothetical_protein_bmyco0001_31490, Phr family secreted Rap phosphatase inhibitor. Phr peptides are short peptides, best conserved in their amino-terminal regions, that are almost always encoded immediately downstream of a Rap phosphatase. A portion of the Phr peptide is secreted, enters another cell, and forms a quorum-sensing system by inhibiting its Rap phosphatase partner. The set of Phr peptides recognized by this N-terminal region model is disjoint from the PhrC/PhrF set recognized by pfam11131. [Regulatory functions, Protein interactions].	6.04814e-06
NZ_CP053934.1\|WP_000236550.1\|1660358_1661036_-\|YdcF-family-protein	gnl\|CDD\|99750	cd06259, YdcF-like, YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been idenitified. The family also includes Escherichia coli sanA and Salmonella typhimurium sfiX, which are involved in vancomycin resistance; sfiX may also be involved in murein synthesis.	1.44935e-21
NZ_CP053934.1\|WP_000646398.1\|1653206_1654205_-\|NADP-dependent-oxidoreductase	gnl\|CDD\|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	2.34296e-150
NZ_CP053934.1\|WP_002036901.1\|1662568_1663813_+\|MFS-transporter	gnl\|CDD\|341028	cd17475, MFS_MT3072_like, Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily. This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.50317e-96
NZ_CP053934.1\|WP_042510988.1\|1655186_1656806_+\|FAD-dependent-monooxygenase	gnl\|CDD\|366675	pfam01494, FAD_binding_3, FAD binding domain. This domain is involved in FAD binding in a number of enzymes.	2.53951e-107
NZ_CP053934.1\|WP_000275806.1\|1649354_1649954_+\|protease-synthase/sporulation-negative-transcriptional-regulator-PaiB	gnl\|CDD\|377290	pfam04299, FMN_bind_2, Putative FMN-binding domain. In Bacillus subtilis, family member PAI 2/ORF-2 was found to be essential for growth. The SUPERFAMILY database finds that this domain is related to FMN-binding domains, suggesting this protein is also FMN-binding.	3.20741e-71

>NZ_CP053934.1|WP_000417237.1|1657411_1658065_+|hypothetical-protein
MEKYHGKSTEQIIQKLMPGSVRSSVVMVWVVINFMILTPFLFPPTFTIYLYIILPFLLIANIWGVWVFFYKPNELRLVHILYNGFMGITFSFGSFIVIQKMAYTFIKIETPLFFIVTFLLYILTNYKLISIGMKSFLRRLNNEENDNIKISPIVYLSGLGYVIGQICIGTLSQNGLATVLILVFSLFAVVLSISGVYIWVYVDLKRKEMDGMHNGQI
>NZ_CP053934.1|WP_000933354.1|1657133_1657307_-|hypothetical-protein
MLNLIPSVTILAPIETPKPIQAPATVPIGPPKTVPTAAPSLAPAKALTAVVPTPIAA
>NZ_CP053934.1|WP_042510988.1|1655186_1656806_+|FAD-dependent-monooxygenase
MESNDVPVLIVGGGLSGLASALFLAKHNIEYLLIERHLSTAIHPKAGGITFRTMELFRELGLEQRIRSAGKTLENCRGRIAVHTIAEANQEELAQMRANQYENDEKLLQKIEEISPSKQTACYQITLEEIMLQEARILGGELSFYHELVSYEQNEQGVIATIRNRETEKESVIHCDYVIAADGAKSKIREQLGISAEGRGTIGGYYMNIYFEADVSEFMQGDAFGFSMVLHPEVLGALIPVDNARRWIYHVSYDPLKGERPEDFTIERCKQIIQTAIGSTNVEPEIVSVLPWKAAESTATKFQDNRIFLVGDSAHIMPPTGGFGSNTGIQDAHNLAWKLAAVIEGKAQPKLLETYHEERYPVAKLTTDYASSLLFHAANREEGSLNNMDGLAVTVGYQYCSEVIIDDSVTPHRMDSVELNGRPGTRAPHFFGTYDGKEISILDLLGDDFVLLTIAENRTWAECVQNVSSTLGINIKFYSVGLRGDFIAQEDIFSKLYGIENGGAVLIRPDGFIGWCSEKEVVNLDVVLEEVMGNLLCDF
>NZ_CP053934.1|WP_000571882.1|1654314_1654719_-|winged-helix-turn-helix-transcriptional-regulator
MIEMNKQEQLNVIKKDFIDSQKVLLAIGDETRQAILLVLMETECQTGLRVGEITKQTHLSRPAVSHHLRILREAGIILMRKEGTKNFYYIDIRTKLSLLKNLVLDIEKLLHNFYPTLTGSKTPTSEFSESKEFR
>NZ_CP053934.1|WP_000646398.1|1653206_1654205_-|NADP-dependent-oxidoreductase
MKAMIIDKYGKVPMRMAEVPIPEINEHEVLAEIHAASINPIDFKIRDGKVKMLLKYEMPLILGNDFAGVIIKVGSKVTRFKIGDEIYARPRKNKIGTFAEYIAIHEDDIALKPKNLSFEEAASIPLVGLTSYQALHDIMQLQKDQKILIHAGSGGVGTFAIQLAKIMGATVTTTASEAGSDLVKSLGADQIINYKTEKFEEILKDYDAVFDTIGGTTLEKSFDIIKSGGNIVSVSGIPNARFGKEFGSGFFKTFLFSLASKKLTALEKKHNAQYSFLFMKPSGDQLRTIANYIEAGKIKPVIDRVFPFEDAQKAMEYSEAGRAKGKIIVKMK
>NZ_CP053934.1|WP_042510987.1|1651561_1653028_-|YdiU-family-protein
MTKNNEAGWNLDHSYTTLPQSFYTEIPPTPVSSPELVKLNHSLAISLGFNPEELKKEAEIAIFAGNAFPEGAHPLAQAYAGHQFGHFNMLGDGRALLIGEQMTPSGKRFDIQLKGSGPTPYSRRGDGRAALGPMLREYIISEAMYALDIPTTRSLAVVTTGEPTYRETKLPGAILTRVASSHIRVGTFQYAAARGSIEDLQSLADYTIKRHYPEIEAHENRYTALLQEVIKKQASLIAKWQLVGFIHGVMNTDNITISGETIDYGPCAFMDNYDQGTVFSSIDTQGRYAYGNQPYMAAWDLARLAESLIPILHEDEEEALKIAQDEISKFSVQYEKQWFLGMKKKLGLFSNEEQDQSLIEQLLKMMEKFKADYTNTFRSLTLNTIENTALFESPEFKEWYKLWQSRLERQEESKENAYEMMKNNNPSIIPRNHRVEEALEAAVTNGDYSVMEKLLEALSNPYAYATEQEEYCVPPAPTNRPYRTFCGT
>NZ_CP053934.1|WP_001102724.1|1650212_1651307_-|RapH-N-terminal-domain-containing-protein
MNVQLQGNEQITKLFNDWYLAMLKQDVSQATNLKHEIEENELNFEEDENLALYYSLLDFRYKVLVDSLSISKDCFDKIDSYLISSNHPLAYYYHFFKGIYATLTTDFNLASEHYEQAKLLLVNNTDNLEHAEFYYRMAIFHYHFYQPIESIEYATKAKAIFDKHTGYEVKVGLCKNTLGASFVYLKQYEQAEEQYNSAIHLLQKSNEKELILSVRNNLGWLYASQNLSTLAIRHLSEVTEKKPTHFKALFLQAREHSKLDETSIAEGLIQKGVKICTELNNEEYIYHFKILNELNNNVASEELETIILKGITFFDKELLYNYTQEYSEKLAVKFYSENNHIKASEYFHKALQAKEKTFEKGALK
>NZ_CP053934.1|WP_000592015.1|1650027_1650216_-|Phr-family-secreted-Rap-phosphatase-inhibitor
MIKKISSVFLGLSVFGILATGIHSSFTYQAGHADLPAPQRPDLVQSVDASKDYNSTTTEKVL
>NZ_CP053934.1|WP_000275806.1|1649354_1649954_+|protease-synthase/sporulation-negative-transcriptional-regulator-PaiB
MYIPKYFAIQDEKMKYEIMEQNSFATLFSQHNGEPYATHLPLLLNRETLTLHGHFARPNEQWKDIGTQQVLAIFQGPHSYISPSWYETKNAVPTWNYVAVHVYGELELVEDEQELIDSLQDLVDTYEDPQSTYSLNDVDPNYMEGLSKGIVGFKIKISKIEGKAKLSQNHSVARRKLVVEELEKVGSEGSRGIAELMRK
>NZ_CP053934.1|WP_001172053.1|1648321_1648669_+|DUF4260-domain-containing-protein
MQKRIVHFEGLVVFVATIYMYSLYEFSWIIFLIFLLAPDLSMLAYGINNHIGANIYNLFHTYIISILIVIIGVYFKVDTVIMIGLIWTAHIGMDRMFGYGLKYETEFKGTHIQRL
>NZ_CP053934.1|WP_001226323.1|1659369_1660314_+|glycerophosphodiester-phosphodiesterase
MRKIISVLVIFFMTGSIFAGGAVHAKAEGKHEWNKNKFLNIAHRGASGHAPEHTFASYDLVKKMKADYLELDIQLTKDGQLIAMHDTAVDRTTNGTGEVRDKTLSEIKSLDAGSWFNKAYPEKAKQEYVGQKVPTLEEIFQKYGRSMKYYIETKSPDVYPGMEEKLLALLEKYNLIGQNMSSSRVMIQSFSKDSLKKIHSMNENIPLVQLLWYYPNENNEIVEWSSITHEPKRVTNDDFQEIKKYAVGIGPNLRNDNGELIIDESYMKMARKNGLLIHPYTINEKPDMRLLIKWGATGMFTNYPDRLHSVLKEK
>NZ_CP053934.1|WP_000236550.1|1660358_1661036_-|YdcF-family-protein
MVIPKYPDVPTLTKKQIDQITEITFLKEITPQKCDVIFVFGGSHPGNWQAPLEAYRQGLGNRIIVTGGTSLHGMKHPSWNYGDLSEAEVIVNKLMENGVPKGAILFEKNSLHSIANVIEAKKIFDFTKINRLLFVCKNLGAGRQYRVLKKHLPKTITCIPYTFDTSFDGEFIMNRYNWMENEKSRSMIFGEYLRNVCYGRKGGIEPPKKEVQGLEEYVSYYYNLA
>NZ_CP053934.1|WP_000544596.1|1661129_1661639_-|DUF3916-domain-containing-protein
MHEKKIRGMKRKTNAMIKRIEEHTKMFPSTFYNDEYWYMPLPVSQDFIESHKTPRKVKRLCIQTLIDRVNHLIKIKPSDTHTYRVVALISIENLWRSQIIVFKNDDYFHNFFNRNNEFQKWILLSNEIDFWETWGISICPTPQMLRFQEVIYDEDTIDEKEIWFIGELS
>NZ_CP053934.1|WP_000351706.1|1661631_1662483_-|LysR-family-transcriptional-regulator
MDIKDLTVFYEVAKENNISHAAKNLNYVQSGVTMRMKQLENELGVPLFYRNGKGVTLTSNGEILLTYAKQIIHLMDQSIKAVQSNGTEPKGTLKIGCTESTTAVRLPSILTTYYEKYPEVELILETNTTEQLIKLVLDRKLDGAFIAGSTQHNELHSNVFHEEELVLISKKTLSSLKDIEDMNLLAFSHGCYYRSLLEDWLQEEDISPKRVLEFGTIEAILACVKSSMGVAIMMKSILKGHEHDVSFNPLPNSFNKVPTTFITRNDIFRSAALQKFMEVTHNA
>NZ_CP053934.1|WP_002036901.1|1662568_1663813_+|MFS-transporter
MEEDGGIIVLMEERMNSTYKWVMLIVATIAQTTATLITYGVGVFALFWKEEYALTNMESGLLVSVVNVGPLFCMLFVGRLLDQYNEKILISISSFLLGSSLLLTNIVSGFNGLLFVLLLIGMFYSVSQPGGSKVILKWFPKENRGLAMGIRQAGIPIGGALAGVLIPFLTVQYNMTYAINSIACICIIGGVLFFVFYKEPYVEEEARKGHIKISFWMELKVVICKKELYPIYITGICMISLQMVLVGHFMKFLAGEQSITSIVAGTVFSVMFFSGMIGRVALAAISDVFYKGNRRIPLFIAVCASIGLILLLVMNIHTITSGVLYSISALLGFFSIGWFSLFIAEVAELASEESVGITVSVALTLNQIAIIVAPVLFGYIVDEKGYAYAWLCIVVLLSISAVSLYRRNKKIKES
>NZ_CP053934.1|WP_000798800.1|1663912_1664143_-|hypothetical-protein
MKNTDKRNRLDDMMFHYRVTKNNIVLIEYYGKQIMILKGTAAEKFLNKINHAHNDTEKQLIMAKVTGNFKRGNEHQ
>NZ_CP053934.1|WP_000915215.1|1664399_1665533_+|serine-hydrolase
MLKKWLIVFFIFAVFSGSVVALIHASKGKKYDIKAFSNLNNKQKHDMQEVDANEKKHYEVVAGKLDQYLKDKGFNGSVLVASKDHVILRKGYGYANVKDKVFTTPRTKYRIGSITKTVVAISIMQLKEKGKLNIEDNVNKYIPSFPADKNITLRNLLTHTSGLPDQGKGRVDAASRLKLVTWIGSQALQFPAGTGWKYTDYNYMVLAYIVEKITNKPLAEYVKENIFTPVEMHESGMGATLPEDIFLAEGYTRKDNELIAAPRLKMNWLYGCGEMYTTVEDMKRLDEAIMNGKLLSKQSVLDMFTASPARKYGFSFYTYPDYYHNHGVLAGWNTFNNFNWDKRTFVILFSNVQNGMNDAFNQEFRKMANDLIEAKGA
>NZ_CP053934.1|WP_000137564.1|1665568_1667356_-|oligoendopeptidase-F
MTELKDRLQVADKEKWNLTDIYDTIEDWESDFHKIEVLTNELHEFNGNIHDGNSLLAYLTKSEEISSIISLMFAYARLQSDLDTRDTDAQSLVDKVSQLHVKVSAAKSFFSPFLLSVDENTLHTYIEEAEGLQYYKEDLFELYRYKKHVLNKDQEEILSQMGEALSSPQHTYGMLNNADILFGEVTSNDGEKVTLTRGMYAKLIEDESREKRKEAYKAYYKPYVQLKNSIASTLSAAIKNNVTVSKLRKYPSALEKSLFGDMVPKEVYENLIDTTKKNIQSLHTYNKLRKEKLNVDELRQYDLSVDLVQGVKQDIPYDNAFDIMIESLAPLGEEYIETLKSFKDKRYIDVRETPGKRSGAYNFGVYGVHPFILLNHHDDLNSLFTLTHECGHGMHTHYSHGYQPRISAHYTIFVAEVASTVNEVLLIHHLLKEAKDANVRNHLVNHFIEKFKGTFFTQIMFAEFEKITHEMAQQGKPLNAQVFSEVYENLFREYNGDSLVFDEEVKYGWARIPHFYRPFYVYKYATGFASAIQIADKLLSGDPNAQKNYLEFLKGGSSDYPLNLLKKAGVDLTTPEPIESALNRFSELVEEFSTL
>NZ_CP053934.1|WP_000129215.1|1667472_1668264_-|arylamine-N-acetyltransferase
MTDFQKQFFARLNIEEKQKVSFEDLSNIMYAMAQTVPFENLNVLEKNFKEISQENLKEKILVNNRGGLCYELNPTMYYFLKDAGFDVYLVSGTVYNAANSIWAVDSGHIATILKHHNELYLIEVGFGSYLPLAPVPFSGEVVQSVTGDYRIRKEMTEKGNYMLEMRKNDEFLDQSSTDDWTLGYAFYIEEVDEKKANAAQKIIVEHDGSPFNKVPLIVKLTEDGHASLTKDSLTIAKNGKKTKEKVTDVQYKKLLHSKFGITL
>NZ_CP053934.1|WP_000473534.1|1668479_1670021_+|alpha-amylase
MFKKITIVGLSVVLFLPSIYGESKVYADTINNGTLMQYFEWYAPSDGNHWNRLRTDAENLAQKGITSVWIPPAYKGTTQNDVGYGAYDLYDLGEFNQKGTVRTKYGTKAQLKSAIEALHKQNIDVYGDVVMNHKGGADYTETVTAVEVDRNNRNVEVSGDYEISAWTGFNFPGRGDNYSNFKWKWYHFDGTDWDEGRKLNRIYKFRGIGKAWDWEVSSENGNYDYLMYADLDFDHPDVANEMKNWGTWYANELNLDGFRLDAVKHIDHEYLRDWVNHVRQQTGKEMFTVAEYWQNDIQTLNNYLAKVNYNQSVFDAPLHYNFHYASKGNGNYDMRNILNGTVMQNHPALAVTLVENHDSQPGQSLESVVSPWFKPLAYAFILTRAEGYPSVFYGDYYGTSGNSSYEIPALKDKIDPILTARKNFAYGTQRDYLDHPDVIGWTREGDSVHANSGLATLISDGPGGSKWMDVGKNNAGEVWHDMTGNQTNTVTINKDGWGQFHVSGGSVSIYVQQ

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Crispr_ID: NZ_CP053934_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053934_3

3788734-3788989

Orphan

Consensus_repeat	Method
TTCTCATGCGGAAGGTAAACATACA	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP053934_3

>merge|NZ_CP053934|3|3788734-3788989|CRISPRCasFinder
CTCTAATGCAGAGGGTACAGCTTCACATGCAGAAGGGCTTCTTACACATGCAAAAGGTTCTTTCTCTCATGCCGAAGGATCAAAAACGAAAGCAACTGGACATAGTTCCCATAGTGAAGGAAGTGAAACGACAGCAGGTGGCTCTTATTCTCATGCGGAAGGTAAACATACAATCGCTTTAGGCGAAGCAGCACATGCAGAAGGAACCGCGACTATCGCTAACGGATTCTCTTCTCATGCGGAAGGTAATCATACA

>NZ_CP053934|3|2|3788734-3788989|CRISPRCasFinder
CTCTAATGCAGAGGGTACAGCTTCA	CATGCAGAAGGGCTTCTTACACATGCAAAAGGTTCTTT
CTCTCATGCCGAAGGATCAAAAACG	AAAGCAACTGGACATAGTTCCCATAGTGAAGGAAGTGAAACGACAGCAGGTGGCTCTTA
TTCTCATGCGGAAGGTAAACATACA	ATCGCTTTAGGCGAAGCAGCACATGCAGAAGGAACCGCGACTATCGCTAACGGATTCTC
TTCTCATGCGGAAGGTAATCATACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053934.1\|WP_000651510.1\|3778823_3779504_-\|streptomycin-biosynthesis-protein-StrF	unknown	unknown	gnl\|CDD\|379345
NZ_CP053934.1\|WP_001004743.1\|3784289_3785048_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_CP053934.1\|WP_000673194.1\|3790594_3791392_-\|NAD-kinase	unknown	unknown	gnl\|CDD\|235317
NZ_CP053934.1\|WP_000428855.1\|3783307_3784153_+\|O-methyltransferase	unknown	unknown	gnl\|CDD\|377550
NZ_CP053934.1\|WP_000003393.1\|3795170_3796997_-\|oligoendopeptidase-F	unknown	unknown	gnl\|CDD\|341071
NZ_CP053934.1\|WP_042511609.1\|3782306_3783185_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375999
NZ_CP053934.1\|WP_001079105.1\|3789685_3790579_-\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NZ_CP053934.1\|WP_001984995.1\|3794877_3795051_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053934.1\|WP_000654694.1\|3786132_3787293_+\|rod-shape-determining-protein-RodA	unknown	unknown	gnl\|CDD\|274033
NZ_CP053934.1\|WP_042511610.1\|3787367_3788108_+\|bis(5'-nucleosyl)-tetraphosphatase-PrpE	unknown	unknown	gnl\|CDD\|184187
NZ_CP053934.1\|WP_001271203.1\|3779516_3780203_-\|streptomycin-biosynthesis-protein-StrF	unknown	unknown	gnl\|CDD\|379345
NZ_CP053934.1\|WP_001087866.1\|3780199_3780889_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369778
NZ_CP053934.1\|WP_001081482.1\|3791410_3792049_-\|GTP-pyrophosphokinase-family-protein	unknown	unknown	gnl\|CDD\|225232
NZ_CP053934.1\|WP_000612273.1\|3797047_3798292_-\|competence-protein	unknown	unknown	gnl\|CDD\|226875
NZ_CP053934.1\|WP_042511608.1\|3781040_3782141_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133005
NZ_CP053934.1\|WP_000043381.1\|3793356_3793755_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|381281
NZ_CP053934.1\|WP_000191105.1\|3792597_3793176_+\|CYTH-domain-containing-protein	unknown	unknown	gnl\|CDD\|143627
NZ_CP053934.1\|WP_000360638.1\|3793754_3794648_+\|DsbA-family-protein	unknown	unknown	gnl\|CDD\|372699
NZ_CP053934.1\|WP_001180009.1\|3792079_3792451_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053934.1\|WP_000427734.1\|3785054_3785990_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|366154

Protein	Function_ID	Function_description	E-value
NZ_CP053934.1\|WP_000651510.1\|3778823_3779504_-\|streptomycin-biosynthesis-protein-StrF	gnl\|CDD\|379345	pfam13712, Glyco_tranf_2_5, Glycosyltransferase like family. Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis.	6.29242e-108
NZ_CP053934.1\|WP_001004743.1\|3784289_3785048_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	9.00939e-20
NZ_CP053934.1\|WP_000673194.1\|3790594_3791392_-\|NAD-kinase	gnl\|CDD\|235317	PRK04885, ppnK, inorganic polyphosphate/ATP-NAD kinase; Provisional.	0
NZ_CP053934.1\|WP_000428855.1\|3783307_3784153_+\|O-methyltransferase	gnl\|CDD\|377550	pfam05711, TylF, Macrocin-O-methyltransferase (TylF). This family consists of bacterial macrocin O-methyltransferase (TylF) proteins. TylF is responsible for the methylation of macrocin to produce tylosin. Tylosin is a macrolide antibiotic used in veterinary medicine to treat infections caused by Gram-positive bacteria and as an animal growth promoter in the swine industry. It is produced by several Streptomyces species. As with other macrolides, the antibiotic activity of tylosin is due to the inhibition of protein biosynthesis by a mechanism that involves the binding of tylosin to the ribosome, preventing the formation of the mRNA-aminoacyl-tRNA-ribosome complex. The structure of one representative sequence from this family, NovP, shows it to be an S-adenosyl-l-methionine-dependent O-methyltransferase that catalyzes the penultimate step in the biosynthesis of the aminocoumarin antibiotic novobiocin. Specifically, it methylates at 4-OH of the noviose moiety, and the resultant methoxy group is important for the potency of the mature antibiotic. It is likely that the key structural features of NovP are common to the rest of the family and include: a helical 'lid' region that gates access to the co-substrate binding pocket and an active centre that contains a 3-Asp putative metal binding site. A further conserved Asp probably acts as the general base that initiates the reaction by de-protonating the 4-OH group of the noviose unit.	1.13671e-149
NZ_CP053934.1\|WP_000003393.1\|3795170_3796997_-\|oligoendopeptidase-F	gnl\|CDD\|341071	cd09608, M3B_PepF, Peptidase family M3B, oligopeptidase F (PepF). Peptidase family M3B oligopeptidase F (PepF; Pz-peptidase B; EC 3.4.24.-) is mostly bacterial and includes oligoendopeptidase F from Lactococcus lactis. This enzyme hydrolyzes peptides containing between 7 and 17 amino acids with fairly broad specificity. The PepF gene is duplicated in L. lactis on the plasmid that bears it, while a shortened second copy is found in Bacillus subtilis. Most bacterial PepFs are cytoplasmic endopeptidases; however, the Bacillus amyloliquefaciens PepF oligopeptidase is a secreted protein and may facilitate the process of sporulation. Specifically, the yjbG gene encoding the homolog of the PepF1 and PepF2 oligoendopeptidases of Lactococcus lactis has been identified in Bacillus subtilis as an inhibitor of sporulation initiation when over-expressed from a multicopy plasmid. This PepF family includes Streptococcus agalactiae PepB, a group B streptococcal oligopeptidase which has been shown to degrade a variety of bioactive peptides as well as the synthetic collagen-like substrate N-(3-[2-furyl]acryloyl)-Leu-Gly- Pro-Ala in vitro.	0
NZ_CP053934.1\|WP_042511609.1\|3782306_3783185_+\|hypothetical-protein	gnl\|CDD\|375999	pfam18573, BclA_C, BclA C-terminal domain. This is the C-terminal domain of BclA (Bacillus collagen-like protein of anthracis) which is expressed on spores of Bacillus species. Trimers of the C-terminal domain (CTD) form the tips of the spore's hair-like nap and are the immunodominant target of vertebrate antibodies and drive trimerization. Structure analysis indicate the C-terminal region of the peptide folding into an all-beta structure with a jelly-fold topology, similar to the first human complement C1q, a member of the tumor necrosis factor (TNF)-like family. The C-terminal globular domain has been shown to be located on the exterior of the exosporium, and therefore is critical in determining the immunogenicity of the spore in a mammalian host.	1.99956e-18
NZ_CP053934.1\|WP_001079105.1\|3789685_3790579_-\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	7.41091e-101
NZ_CP053934.1\|WP_000654694.1\|3786132_3787293_+\|rod-shape-determining-protein-RodA	gnl\|CDD\|274033	TIGR02210, Rod_shape-determining_protein_RodA, rod shape-determining protein RodA. This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	1.52707e-99
NZ_CP053934.1\|WP_042511610.1\|3787367_3788108_+\|bis(5'-nucleosyl)-tetraphosphatase-PrpE	gnl\|CDD\|184187	PRK13625, PRK13625, bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional.	0
NZ_CP053934.1\|WP_001271203.1\|3779516_3780203_-\|streptomycin-biosynthesis-protein-StrF	gnl\|CDD\|379345	pfam13712, Glyco_tranf_2_5, Glycosyltransferase like family. Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis.	4.87129e-112
NZ_CP053934.1\|WP_001087866.1\|3780199_3780889_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369778	pfam08242, Methyltransf_12, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	1.33577e-17
NZ_CP053934.1\|WP_001081482.1\|3791410_3792049_-\|GTP-pyrophosphokinase-family-protein	gnl\|CDD\|225232	COG2357, COG2357, PpGpp synthetase catalytic domain [General function prediction only].	1.66713e-95
NZ_CP053934.1\|WP_000612273.1\|3797047_3798292_-\|competence-protein	gnl\|CDD\|226875	COG4469, CoiA, Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only].	8.92237e-59
NZ_CP053934.1\|WP_042511608.1\|3781040_3782141_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|133005	cd02511, Beta4Glucosyltransferase, UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide. UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.	7.94856e-55
NZ_CP053934.1\|WP_000043381.1\|3793356_3793755_+\|hypothetical-protein	gnl\|CDD\|381281	cd14772, TrHb2_Bs-trHb-like_O, Truncated hemoglobins, group 2 (O); Bacillus subtilis TrHb like. The M- and S families exhibit the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments. Truncated hemoglobins (TrHbs, 2/2Hb, or 2/2 globins) or the T family globins adopt a 2-on-2 alpha-helical sandwich structure, resulting from extensive and complex modifications of the canonical 3-on-3 alpha-helical sandwich that are distributed throughout the whole protein molecule. TrHbs are classified into three main groups based on their structural properties and named after Mycobacterium sp. genes glbN, glbO, and glbP: TrHb1s (N), TrHb2s (O) and TrHb3s (P). TrHb2's belonging to this group include monomeric Bacillus subtilis trHb (Bs-trHb), which exhibits an extremely high oxygen affinity, and a dimeric TrHb2 from the thermophilic aerobic spore forming bacterium Geobacillus stearothermophilus(Gs-trHb).	1.17037e-69
NZ_CP053934.1\|WP_000191105.1\|3792597_3793176_+\|CYTH-domain-containing-protein	gnl\|CDD\|143627	cd07762, CYTH-like_Pase_1, Uncharacterized subgroup 1 of the CYTH-like superfamily. Enzymes belonging to the CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) superfamily hydrolyze triphosphate-containing substrates, require metal cations as cofactors, and have a unique active site located at the center of an eight-stranded antiparallel beta barrel tunnel (the triphosphate tunnel). The name CYTH originated from the gene designation for bacterial class IV adenylyl cyclases (CyaB) and from thiamine triphosphatase. Class IV adenylate cyclases catalyze the conversion of ATP to 3',5'-cyclic AMP (cAMP) and PPi. Thiamine triphosphatase is a soluble cytosolic enzyme which converts thiamine triphosphate to thiamine diphosphate. This domain superfamily also contains RNA triphosphatases, membrane-associated polyphosphate polymerases, tripolyphosphatases, nucleoside triphosphatases, nucleoside tetraphosphatases and other proteins with unknown functions. Proteins of this subgroup are of bacterial origin and have not been characterized.	1.94434e-83
NZ_CP053934.1\|WP_000360638.1\|3793754_3794648_+\|DsbA-family-protein	gnl\|CDD\|372699	pfam13743, Thioredoxin_5, Thioredoxin.	5.36453e-93
NZ_CP053934.1\|WP_000427734.1\|3785054_3785990_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	1.94506e-22

>NZ_CP053934.1|WP_042511610.1|3787367_3788108_+|bis(5'-nucleosyl)-tetraphosphatase-PrpE
MKYDIIGDIHGCLQEFQNLTEKLGYNWSSGLPVHPDQRKLAFVGDITDRGPHSLRMIEIVWELVIHKKVAYYAPGNHCNKLYRFFLGRNVTVAHGLETTVAEYEALPSHKQNMIKEKFITLYEQSPLYHVLDEKRLLVCHAGIRQDYIGRQDKKVQTFVLYGDITGEKHADGSPVRRDWAKEYKGTTWIVYGHTPVKEPRFVNHTVNIDTGAVFGGRLTALRYPEMETVSAPSSLPFVPEKFRPIS
>NZ_CP053934.1|WP_000654694.1|3786132_3787293_+|rod-shape-determining-protein-RodA
MKDPNSQYQIDYVLLCILFAIGTVSCFAIASAQASLPPFLQNVNFVLKQIQWYFIGFIAIGVIMIIDFDRYQKIAWYLYSFALVLLIGLELQVPGAITIKGATAWYRLPGIGNFQPSEIMKLFLIIVTGRIIANHNEKYFYRTIHDDFLLLGKICATSLPPLLLIAKEPDLGNTMVISAMLAAMILVSGIRWRFIFGLVSGIFVTAVTLTYIFFTHTKFFKTHILQEYQLNRFYGWLAPYKYDAQGYQLRQAFLATGSGEMQGKGWENGQVYFPEPHTDFIFTNVAEQFGFLGASVIIAIFFLLIFRMIHIAIESNDPFGSYICAGTIGMFTFQVFQNIGMTIGLLPITGITLPLMSYGGSSLLTYMIAIGFVLNVRSRTKIFMFN
>NZ_CP053934.1|WP_000427734.1|3785054_3785990_+|glycosyltransferase-family-2-protein
MENIKNVPLVSILIPTYNRPHYFKIALESALAQTYSNIEIIVGDDSTNNETEKLIYRDYLHKHKHITYIRNPSTLGQFHNALMLLEQSNGEYINFLMDDDIFYNNKIEKMMFYFQKDLDQNLALITSYRTWINDDGDIIEQHPSMKKLYDEDTLLNGKDFGNRMLILGQNIIGEPTTVLFRKRLLTEPFGTLNGRNYNCSVDMASWISLLSKGDAIYITEPLSSFRLHTGQQVHHKYLEGCEDFSHLVLHSKKYGFLQDIDYYKTSLLKACEWYKNATTFYQLYPELIPTTDTHTRLSHCLNIVTKELHAI
>NZ_CP053934.1|WP_001004743.1|3784289_3785048_+|class-I-SAM-dependent-methyltransferase
MNENEKKITLIPPPELVQYVGGHFEEVGKEFMQYFIEIGNLKSNETVLDVGCGIGRMAVPLMNYLSDDGTYYGFDLFNKGITWCKNNISTRRNNFHFEHVDIYNQFYNPDGKEDASQYKFPYEDESFDFIFLTSVFTHLLPKELEHYVREIARVLKKDGRCFITFFLINPESSYYLNAGLSPLGFYHQIDNCYVLNKDIPNFAVAYPEEDIRTLLNKYGLEMQTPPHYGSWCGRTEHTSYQDIILTQKISER
>NZ_CP053934.1|WP_000428855.1|3783307_3784153_+|O-methyltransferase
MENKSAVQLYLELLKKTILFEIWLEYEPYLPASLHISKELSYEPVTVPLPLFLKQYVENHNLKIVNPNVSNNERQGGKDWPRAAHSMVGRKRMNQLQEAMETVVKENIEGDFIETGVWRGGSCIFMNGFLQANNITDRTVWVADSFEGLPAPNLEQYPKDYGDYLHTFDYLRVSLETVQENFRKYDLLNDQVKFLKGWFKDTLPSAPIEKIAIARLDGDMYESTMDSLVNLYDKVSIGGFIIIDDYGLITCAEAVTDFRSERNIKTPMTQIDDFGIFWRKE
>NZ_CP053934.1|WP_042511609.1|3782306_3783185_+|hypothetical-protein
MSNNNYSNGLNPDESLSASAFDPNLVGPTLPPIPPFTLPTGPTGPTGPTGPTGPTVPTGPTGPTGPTGPTGPTGPTGPTGPTGPTGDTGTTGPTGPTGDTGTTGPTGPTGDTGTTGPTGPTGDTGATGLTGPTGDTGATGPTGPTGATGLTGPTGPSGLGLPAGLYAFNSGGISLDLGINDPVPFNTVGSQFGTAISQLDADTFVISETGFYKITVIANTATASVLGGLTIQVNGVPVPGTGSSLISLGAPIVIQAITQITTTPSLVEVIVTGLGLSLALGTSASIIIEKVA
>NZ_CP053934.1|WP_042511608.1|3781040_3782141_-|glycosyltransferase-family-2-protein
MLNKQGITISLCMIVRDEEKTIARCLDSVEKIVDEIIVVDTGSIDRTKEIVEKYTSNIYDFQWIDDFAAARNFSFSKATQEYILWLDADDVLLEDAQEALKLLKRELNPKIDAVSMPYHLAMDSNGKPLYCTKRNRLVKREKQFQWFGKVHEYLAISGETFSSNVAITHKKEKKVTNRNLKIFQDAVAAGEELSPRDLFYYANECMDNQKYDDAVLLYETFLNQDEGWYEEKIYACGKLGDCYAKLGLWEKAVESCVKSFRYAIPRGENCTRIGYIYMEQQKYNEAIFWFKLATEVPMATESPFHSPASYTWLPYLQMCICYSKLGEQDKAYYYNELAASYVPNNAAIEYNRKYFRSIFDQQKKSL
>NZ_CP053934.1|WP_001087866.1|3780199_3780889_-|class-I-SAM-dependent-methyltransferase
MNSPKNSLYEEKSGHYYNAVNPNLLKHIKKEWKEVLDIGCSSGALGAAIKENGTRVSGIEAFPEAAEQAKEKLDHVVLGDIETMEMPYEEEQFDCVIFGDVLEHLFDPWAVIEKVKPYIKHNGVILASIPNVAHISVLAPLLAGNWSYTEYGLLDKTHIRFFTFNEMLRMFLKAGYSISKVDRVYIDHKMYEPLIEELYGVCKKYRLGSGFMAETVVFQYIIEAEKSSL
>NZ_CP053934.1|WP_001271203.1|3779516_3780203_-|streptomycin-biosynthesis-protein-StrF
MSAAEKTILFVTCINDSKMYAQCVRHILRLAVPPGYVVQFMPIRNAKSMTSGYNQAISHPAKYKVYIHQDVFIMNVAFLHGLLQLFNEHEHLGMIGMIGAQYVPPNGVWNEGKGVVGKVIGYMNDLFYMASQEQPYHESKTFMPVECIDGLLMATQYDIPWREDLFDGFDYYDVSQSFEFRKAGYTVGVPVQRDAWCIHYHIDVNMTNYEKYRKIFVEHYMSDVNQDE
>NZ_CP053934.1|WP_000651510.1|3778823_3779504_-|streptomycin-biosynthesis-protein-StrF
MKDHTILVVVCINNEELFEQCERQIRNLFVPPGYVVQIFPIRDAKSMASAYNRALSYPAKYKVYIHQDTFLINREMFYTLISLFKDNEKLGLIGVAGAQFLPSNGIWWEGKNLVGKVIEYRRQNYQLLNLDQLFYGNQSFMSVQAIDGLLMATQYDIPWREDLFQGFHFYDVSQSLEFQKAGYLIGIPNQANLWCIHYNGDEFDADTYEKYRKVFVEHYKDILSPS
>NZ_CP053934.1|WP_001079105.1|3789685_3790579_-|RluA-family-pseudouridine-synthase
MNRFTLKWDIESAEEGTLVREFLKTKGISKAALTDIKFHGGAIEVNGQHASVRHQLQVGEELRIFFPVEERSEGMIAEDIPLCIVYEDDAVLVINKEANMSTIPSREHPSGSVANALLSHYDKQYLASTVHIVTRLDRDTSGLMLIAKNRFVHHLLSKQHQQKAVKRTYEAIVHGEMVEREGTIDAPIGRKSDSIIERTVCEEGQRAVTHFRVIDSANHKTHVSLELDTGRTHQIRVHMAHIGHPLLGDNLYGGKRDEMKRQALHSTSLTFYHPILEKEMSFAAMIPSDMQEVLRQT
>NZ_CP053934.1|WP_000673194.1|3790594_3791392_-|NAD-kinase
MKFTIMSKGDQSSDTLASTMKEYLLDFGFIMDEQEPDIVISVGGDGTLLYAFHRYYNRLDETAFVGVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLEVIIRYMNGSKESQYLAMNEATVKSAEGTLVTEVEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMASINNRVFRTVGSPLVLPKHHTCVLKPTAGMNLQITVDHLTMVHQDVKSIQYRVANEKVRFVRFRPFPFWKRVRDSFVADK
>NZ_CP053934.1|WP_001081482.1|3791410_3792049_-|GTP-pyrophosphokinase-family-protein
MNRNWEEFLAPYHQAVAELKVKLKGMRTQFAMLTEHSPIEFVTGRVKSVASIIDKAEKRNVPLDRLREDMQDIAGLRMMCQFVDEIKPVVEYLRKRNDFEIVEERDYVTQKKDSGYRSYHVVISYPVQTIQGEQKVLVEIQIRTLAMNFWATIEHSLNYKYSGRFPEDIKIRLQRAAEAAFLLDEEMSSIRLEIQEAQKAFSRKQETKDSES
>NZ_CP053934.1|WP_001180009.1|3792079_3792451_-|hypothetical-protein
MQNKIQVKSVEKRENALIFCAENSEIEVKGLSARNHVLVDSDNLSFLYILENESSFIYVSIPHTCWEAMHEAMNNDVVMFVRVNDIEMELEGLKEEVEYLVENIEGNANYGEELVTAVEKVFL
>NZ_CP053934.1|WP_000191105.1|3792597_3793176_+|CYTH-domain-containing-protein
MTQEIEIEFKNIVTEEEFHALCKSFSIEVFTKQVNHYFETPNFSLKEAGSALRIRHKGETYTLTLKQPAEVGLLETHQVVTENEAKMMMETNVIISGAVMNQLCKLQIPVSALTYMGSLTTERAETLFEGGTLVFDHSFYYNHDDYEIEFEVQDEETGKAAFIHLLKQHNIPIRHTNNKVKRFFLAKQNKAR
>NZ_CP053934.1|WP_000043381.1|3793356_3793755_+|hypothetical-protein
MSKQPMTPFEAIGGEQCIAILVDTFYSYVSKHPDLSPIFPDDLTETARKQKQFLTQYLGGPNLYTEEHGHPMLRARHLPFEITPKRAEAWLSCMEQAMDDTGVHGHIREFVFERLALTAQHMVNTPNETGEI
>NZ_CP053934.1|WP_000360638.1|3793754_3794648_+|DsbA-family-protein
MDKQEAKHINMPSPSACEHKSVEAYLFIDPLCKDCWEIEPFIIKLWLEYGKYFSIRHIVTGKVDGTNASSHKWNKPANIRFVWEKTTSLHGFSCDGKVHMQEASSTPYLVSMAIKAAELQGRKAGSKFLRKLQEYIFLENVSNPDCELLLACAKDSDIDVEEFKKDLYSASAKKAFQCDLKFTNEMHITEIPSLVFFHANSDEEGIKIAGTYSYDVYVQLLKELVKCEIEPEPLPPLEVLLEATQFISSKEVAFIYDCSKQEIERELKKLQLKRKVQMIDVKCERYWKWIAKEKDLV
>NZ_CP053934.1|WP_001984995.1|3794877_3795051_+|hypothetical-protein
MKKTYIFLIILAVIVSFFLYILSLLQAFPKMIAFPLLFGVIVIALSYFNHKKRFKGF
>NZ_CP053934.1|WP_000003393.1|3795170_3796997_-|oligoendopeptidase-F
MSEQNTAKTLPDRNEIEESSTWRLEDIFQTDTEWEKEFQAIKELLPKLTEFKGKLGDSANNLLEALQYEDEISMRLGKLYTYAHMRYDQDTTNSVYQALNDRATNLYSQVSSSTAYIVPEILSISEDTLQTFLKENRDLSVYEHALEEITRQRPHVLSEAEEALLAEASEVMSASSNTFGMLNNADLKFPSIKGEDGEEVEITHGRYIQFLESDDRRVREDAFKAVYETYGKYKNTFASTLSGAVKRNNFNARVRKYDSARQAALSNNNIPEAVYDQLIESVNDNLHLLHRYIDIRKRALGLDELHMYDLYTPLVPEVKMNVKYEEAQDMLLKSLHVLGDEYVDILKEAYENRWVDVYENKGKRSGAYSSGAYGTNPYILMNWHDNVNNLFTLAHEFGHSVHSYYTRKTQPHVYGDYSIFVAEVASTCNEALLNDYLLKTTEDKKERLYLLNHYLEGFRGTVFRQTMFAEFEHIIHKKVQEGHAVTPDMLTEIYYDLNKKYFGDALVIDEEIGLEWSRIPHFYYNYYVYQYATGFSAATALSKQILEEGQPAVERYINEFLKAGSSDYPIEVLKKAGVDMASPEPVKEALQVFEEKLNELEALLFEEK
>NZ_CP053934.1|WP_000612273.1|3797047_3798292_-|competence-protein
MIPIFIAKRENGEKIHLLDHHDEELLHHMRKRESFFCIACGKEVLMRLGKQKRWHFAHKKVDSCLAFYEAESTYHMYGKELLYRWFKRQNVHVEIEHYLPEIQQRPDIFIERAGRKIAIEYQCANLSIEQLCKRTYSYWQAGIQVIWIIGGNQLKKHSAYWMKFSSIMAFSLQSYPQPLLIFFCSKQKSFMKCTFITSFSTSVAFSHIIYLPIETTTFEMLFSPVPFQREVLNREWKRRKDYFRQNALPILNYNHKSLLRLLYQCKCNPANFPSEIGVPLPSSFAFQTNSFIWQAFLYMKCIGELAVGDCISLKYVCSYIKKYTKRRMLPYFSQHIWKVAVTEYMTFLCYAGVLYKVGMYTYRKIRDAVPLKTGGEIMKHDEICLAHALSLFEAKFNMRGGKGDIIKTDREGIT

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Crispr_ID: NZ_CP053934_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053934_4

3889017-3889110

Orphan

Consensus_repeat	Method
TTTTACTATTTAACGTATTTAAACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP053934_4

>merge|NZ_CP053934|4|3889017-3889110|CRISPRCasFinder
TTTTACTATTTAACGTATTTAAACCGTCTGTTACTTTTCCGGATCCATCTTGTAATTTCCCTATACCGCTTTTGCTATTTAACGTATTTAAACC

>NZ_CP053934|4|3|3889017-3889110|CRISPRCasFinder
TTTTACTATTTAACGTATTTAAACC	GTCTGTTACTTTTCCGGATCCATCTTGTAATTTCCCTATACCGC
TTTTGCTATTTAACGTATTTAAACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053934.1\|WP_000784654.1\|3883173_3883908_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293802
NZ_CP053934.1\|WP_000756262.1\|3900772_3902890_-\|PBP1A-family-penicillin-binding-protein	unknown	unknown	gnl\|CDD\|273955
NZ_CP053934.1\|WP_000103718.1\|3884255_3885269_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP053934.1\|WP_042511632.1\|3903017_3903521_+\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|225209
NZ_CP053934.1\|WP_042511624.1\|3886528_3886834_-\|DUF2087-domain-containing-protein	unknown	unknown	gnl\|CDD\|378279
NZ_CP053934.1\|WP_000726793.1\|3898596_3899532_-\|ferrochelatase	unknown	unknown	gnl\|CDD\|183526
NZ_CP053934.1\|WP_001068232.1\|3886149_3886503_+\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|379617
NZ_CP053934.1\|WP_042511629.1\|3893156_3895523_-\|chitobiase/beta-hexosaminidase-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|225249
NZ_CP053934.1\|WP_000567010.1\|3884087_3884216_+\|YhfH-family-protein	unknown	unknown	gnl\|CDD\|379490
NZ_CP053934.1\|WP_042511623.1\|3881491_3881920_-\|lipoprotein	unknown	unknown	unknown
NZ_CP053934.1\|WP_000897259.1\|3882174_3883164_-\|lipoate--protein-ligase	unknown	unknown	gnl\|CDD\|161920
NZ_CP053934.1\|WP_042511631.1\|3897155_3898577_-\|protoporphyrinogen-oxidase	unknown	unknown	gnl\|CDD\|237009
NZ_CP053934.1\|WP_001055163.1\|3879797_3881330_-\|fatty-acid--CoA-ligase-family-protein	unknown	unknown	gnl\|CDD\|236072
NZ_CP053934.1\|WP_000252614.1\|3899546_3900593_-\|uroporphyrinogen-decarboxylase	unknown	unknown	gnl\|CDD\|234644
NZ_CP053934.1\|WP_042511630.1\|3895763_3897116_+\|DUF4026-domain-containing-protein	unknown	unknown	gnl\|CDD\|338635
NZ_CP053934.1\|WP_042511628.1\|3892716_3893019_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053934.1\|WP_042511627.1\|3890951_3891806_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053934.1\|WP_042511626.1\|3890053_3890626_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP053934.1\|WP_000620029.1\|3885506_3886016_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP053934.1\|WP_002157388.1\|3886870_3887086_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP053934.1\|WP_000784654.1\|3883173_3883908_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293802	cd07716, RNaseZ_short-form-like_MBL-fold, uncharacterized bacterial subgroup of Ribonuclease Z, short form; MBL-fold metallo-hydrolase domain. The tRNA maturase RNase Z (also known as tRNase Z or 3' tRNase) catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors. Two forms of RNase Z exist in eukaryotes, one long (ELAC2) and one short form (ELAC1), the former may have resulted from a duplication of the shorter enzyme. Only the short form exists in bacteria. Members of this bacterial subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	3.04117e-87
NZ_CP053934.1\|WP_000756262.1\|3900772_3902890_-\|PBP1A-family-penicillin-binding-protein	gnl\|CDD\|273955	TIGR02074, Includes:_Penicillin-insensitive_transglycosylase, penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NZ_CP053934.1\|WP_000567010.1\|3884087_3884216_+\|YhfH-family-protein	gnl\|CDD\|379490	pfam14149, YhfH, YhfH-like protein. The YhfH-like protein family includes the B. subtilis YhfH protein, which is functionally uncharacterized. Its expression is repressed by the Spx paralogue MgsR, which regulates genes involved in stress response. This family of proteins is found in bacteria. Proteins in this family are typically between 42 and 53 amino acids in length.	3.52581e-13
NZ_CP053934.1\|WP_042511632.1\|3903017_3903521_+\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|225209	COG2329, COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only].	3.99853e-21
NZ_CP053934.1\|WP_042511624.1\|3886528_3886834_-\|DUF2087-domain-containing-protein	gnl\|CDD\|378279	pfam09860, DUF2087, Uncharacterized protein conserved in bacteria (DUF2087). This domain, found in various hypothetical prokaryotic proteins and transcriptional activators, has no known function. Structural modelling suggests this domain may bind nucleic acids.	7.73896e-25
NZ_CP053934.1\|WP_000726793.1\|3898596_3899532_-\|ferrochelatase	gnl\|CDD\|183526	PRK12435, PRK12435, ferrochelatase; Provisional.	0
NZ_CP053934.1\|WP_001068232.1\|3886149_3886503_+\|PH-domain-containing-protein	gnl\|CDD\|379617	pfam14470, bPH_3, Bacterial PH domain. Proteins in this family are distantly related to PH domains.	8.25131e-17
NZ_CP053934.1\|WP_042511629.1\|3893156_3895523_-\|chitobiase/beta-hexosaminidase-C-terminal-domain-containing-protein	gnl\|CDD\|225249	COG2374, COG2374, Predicted extracellular nuclease [General function prediction only].	4.28434e-71
NZ_CP053934.1\|WP_000103718.1\|3884255_3885269_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.15283e-113
NZ_CP053934.1\|WP_000897259.1\|3882174_3883164_-\|lipoate--protein-ligase	gnl\|CDD\|161920	TIGR00545, Probable_lipoate-protein_ligase_A, lipoyltransferase and lipoate-protein ligase. One member of this group of proteins is bovine lipoyltransferase, which transfers the lipoyl group from lipoyl-AMP to the specific Lys of lipoate-dependent enzymes. However, it does not first activate lipoic acid with ATP to create lipoyl-AMP and pyrophosphate. Another member of this group, lipoate-protein ligase A from E. coli, catalyzes both the activation and the transfer of lipoate. Homology between the two is full-length, except for the bovine mitochondrial targeting signal, but is strongest toward the N-terminus. [Protein fate, Protein modification and repair].	1.02008e-136
NZ_CP053934.1\|WP_042511631.1\|3897155_3898577_-\|protoporphyrinogen-oxidase	gnl\|CDD\|237009	PRK11883, PRK11883, protoporphyrinogen oxidase; Reviewed.	0
NZ_CP053934.1\|WP_001055163.1\|3879797_3881330_-\|fatty-acid--CoA-ligase-family-protein	gnl\|CDD\|236072	PRK07656, PRK07656, long-chain-fatty-acid--CoA ligase; Validated.	0
NZ_CP053934.1\|WP_000252614.1\|3899546_3900593_-\|uroporphyrinogen-decarboxylase	gnl\|CDD\|234644	PRK00115, hemE, uroporphyrinogen decarboxylase; Validated.	0
NZ_CP053934.1\|WP_042511630.1\|3895763_3897116_+\|DUF4026-domain-containing-protein	gnl\|CDD\|338635	pfam13218, DUF4026, Protein of unknown function (DUF4026). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 450 amino acids in length. The family is found in association with pfam10077.	0
NZ_CP053934.1\|WP_042511626.1\|3890053_3890626_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.41808e-14
NZ_CP053934.1\|WP_000620029.1\|3885506_3886016_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	8.97148e-16

>NZ_CP053934.1|WP_002157388.1|3886870_3887086_-|hypothetical-protein
MMKGNLTYYFILNPLIIFLVYALSPILFHKEKYINMKDALGILVVYYVLISGYYLMDVVSERMKKDSKDKQ
>NZ_CP053934.1|WP_042511624.1|3886528_3886834_-|DUF2087-domain-containing-protein
MTESEMKFRDATIRNFFDKEDRLKSIPGQKKKKLVLLEHLISKLNADNQYTEKEMNTFIKQYHDDFCTIRREFIVHGFMDREANMYHINGREVGTKWEELK
>NZ_CP053934.1|WP_001068232.1|3886149_3886503_+|PH-domain-containing-protein
MNPILTTAKQLLHKEETILSTLNCSLTGYMITYNVPYPGMLLTTNRRLLFFSQYKNTLIAEFDYEKILSIETKRRIFDKKIIFYYEDEYITLGYITSSNIEEFIDLLRRKCKISTNS
>NZ_CP053934.1|WP_000620029.1|3885506_3886016_-|GNAT-family-N-acetyltransferase
MIRLAKETDAEAIMDIRKEIILSKTTTKFFIVSPKKLPNDTNAEREKIRKSNEKGNLYIVYEVDNKVVGFLLFNRYELDRLRHAGTMGMGIKEAYCNQGIGTKLIEFLIRWAKEKKGLEKICLGVVSVNDRAIKVYKRMGFVEEGRQRKQIKYEDGSYGDDVLMGFYID
>NZ_CP053934.1|WP_000103718.1|3884255_3885269_-|LacI-family-DNA-binding-transcriptional-regulator
MSTIEDVAKLAGLSRTTVSRVINNHPYVSDEKKKRVQLAMKHLGFVPNSAARRLRKQKTETIAVLVPRITNPFFSRFIEAIEIAASEHKYKLIICQTRYLPEKEMEYLQLLSTKQVDGIILCSLENPWEDVEPYLQHGPIVLCNEYIEEANIPTVKFDHAQGAYIAAKHVLEQGYRNLIFCRGNETKVVSQQRKMGFLRAITEKSRQVEAIDFLENAFSWEDGKRIFHEVLKDKKNPTAILAGGDEVAAGIISEAKRHDWSIPDDLAVIGFDNQILSQITEPGITTIEQPIDEMARKVVDLMMDKIHTKNYRKKELYEFELELLVKGSTMKDTMLLA
>NZ_CP053934.1|WP_000567010.1|3884087_3884216_+|YhfH-family-protein
MIDQPMEFFRNLPTKTCAHCGKEIDEQHEAYHNKCDDCVHEE
>NZ_CP053934.1|WP_000784654.1|3883173_3883908_-|MBL-fold-metallo-hydrolase
MKMTVVGFWGGFPEAGEATSGYLFEHDGFRLLVDCGSGVLAQLQKYITPSDIDAVVLSHYHHDHVADIGVLQYARLITSATKGQLPELPIYGHTFDENGFHSLTHEPHTKGIPYNPEETLQIGPFSISFLKTVHPVTCFAMRITAGNDIVVYSADSSYIPEFIPFTKDADLFICECNMYAHQEAAKAGHMNSTEVASIAKDANVKELLLTHLPHTGNPADLVTEAKQIFSGHITLAHSGYVWNS
>NZ_CP053934.1|WP_000897259.1|3882174_3883164_-|lipoate--protein-ligase
MLFIDNKGITDPRINLAIEEYCVKNLDINETYLLFYINEPSIIIGKNQNTVEEINADYVKEKGIHVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFSNFKKFTEPVTKALGKLGVNAELSGRNDILAEGRKISGNAQFSTKGRMFSHGTLLFDSEIDHVVSALKVKMDKIQSKGIKSIRSRVANITEFLNEEMTTEEFRQLLLETIFEGETEIPTYELTEEDWKEIHKLSEERYRNWDWNYGKSPKFNLQHSHRFPVGQVDVRLEVKKGTVTECKIYGDFFGSLDVHDIEERLTGVQFDKDAFTAALESVDIARYFGNITTEDFLHLFF
>NZ_CP053934.1|WP_042511623.1|3881491_3881920_-|lipoprotein
MKRVMYVVLLLSFVIGIAACNDETSSSRTLLSIGKPAKDNVIYFTHTDNKRKIQEIQDMFQNKKWKRNETFSTVNKTPDVVFSIDEDNTGLPALYVTVYFHEDGADVLNLYGEYTSLNKQELAMLREKMSAYYPKMIFGLVS
>NZ_CP053934.1|WP_001055163.1|3879797_3881330_-|fatty-acid--CoA-ligase-family-protein
MNLVQSLAETAKKKGDKPAYIFMDQSVSYDQLNKMVTRFSSNLAEMGIGKGDNVALVVGNSPHFLVGLYGTMKAGATVIPVNPIYTADEMHYILQNGDVKTIIVLDVLLPVIQSLTTRLPSLENIIICETSSDFNHTETEKMKTFTRMIGAGDLTYEGPELDEEDVAVILYTSGTTGKPKGAMLTHKNLYSNASDVASYLQYTADDRVVAALPMFHVFCLTVAVNAPIVNGATILMLPKFSPKEVFRICRTYEPTIFAGVPTMYNYLYLFEEASAEDVKTLRLCISGGASMPVALLQNFEKRFDVIVSEGYGLSEASPVTCFNPLDRPRKPGSIGTNIWHVENKIVNELGEEVPVGAVGELIVRGPNVMKGYYNAPEDTAATLKDGWLYTGDLAKMDEEGYFYIVDRKKDIVLVGGYNVYPREVEEVLYMHESVAEVVVIGVPDENLGEAVRAYVVLKQTNVTEEELMHYCTLHLAKYKVPKSIEFLTELPKNTTGKLLRRALREKAMQV
>NZ_CP053934.1|WP_042511626.1|3890053_3890626_-|TetR/AcrR-family-transcriptional-regulator
MAIDRKRSIIEAATKSFSAFGYKATTMDQVAKLANVGKGTIYTFFKNKEELFGEIISNLITEMKKVAENAIRSDVSFFENVHRALYSILEFRKEHQLMIKLIQEERDMGTKEVQEVMQQVDVEIVSVIQSYLKIAIDKGEISKCDPEITAFIMLRLYVSLIFDWEKNHEPLEKEKIAELFELYLLKGLSN
>NZ_CP053934.1|WP_042511627.1|3890951_3891806_+|hypothetical-protein
MMRALRLNIKQAFCNRVSLIIMFSGFVLICIYHYYYVIRYLGDAASGPISTDIKWIGFRDNEMDVYLLLMPVIASFPFSTSYNSDKSDGFKPFVSKGISLFPYSITKYIVTFFCGGFLYTFPFILSLLFCKLTIPDGTPTIGSGIINEDGMFANLYFDAPLTYITVYIGINFLFAGLMALLGLAASAWSQKDYMAILFPFAVNSIPYVLLNTIFPTIGGAPIHLYDPKQPLQGMSPYILMIQCAFFFFVSLLMYIQGVKRDRKKYKRRLQKRDRCRKAFQVISD
>NZ_CP053934.1|WP_042511628.1|3892716_3893019_-|hypothetical-protein
MVAQLNGKVMNQLAIFFSIFIIIKFVADVTGLTQSLGMYYLGTLSTNIAYIAFGLAVIFTILGIKKELSKYAIILVCSAIGIQILYAVVFVILWVLAGTP
>NZ_CP053934.1|WP_042511629.1|3893156_3895523_-|chitobiase/beta-hexosaminidase-C-terminal-domain-containing-protein
MAVKKLLSVFLSFILLLSFTGTLVQAEETTSMSVEKAIQVFKQQGKTKGTVEGYIVGYTQSPSKYTKDPAKFDDTNVAIADSPNETNPDKIMPVQLPKGDVRAAVNVKDHPENIGKKVSLTGTLELYFSSPGLKSVTAHKFQGEEQNRVSDVVASPNGGEVAKGTAVTLTTNTEGATIYYTLDGSNPTNKSVRYNGQIIVNENSVVKAIAEKEGLTSSAISTFSFVIVNNEPVRIHDIQGKSHLSPYNGKKVYNVEGVVTALDKNGFYIEDNQPDNDPATSEGMYVYKKDANVAVGDLVQVDGVVEEYVGPGYAERFETDLTTTEIKASRVAVIAKDQPLPAPIVLGETGVKIPDQIIDNDAFGLFDPNEDAIDFYESVEGMRVTMPTPKIIAPQKNGNLYVTVKNGGNKVVTKYGTPVLDENQLNPERLSVKVPRDYVAKVGDTFTGDITGVVGYDYGSFRIAPITELPSVVDGGFKQIGANIQPRLDKLTVATYNIENFSANKKETTDEKVKALAYSIKYNLKMPDIIGVEEMQDNNGTVNDGTTDASLSAKRIIDAVLEIRGPKYEYVEIAPNNNLDGGAPGANIRVGFFYNPSRVKLATVPKLLDKNVVRIGDENPLFESTRKPLAAEFTFQGQNLVVVANHLNSKIGDATPFGKVQPLVLKSEEKRVQLAQEVNNFVQGIQKKNTNAPVVVLGDMNDFEFAKPLKTLEGTILKNMLNTVPKENRYTYIHEGNAQVLDHILVTNNIAPHTIVDPVHLNSNIMKEHGRVSDHDPVLAQIDLKKAS
>NZ_CP053934.1|WP_042511630.1|3895763_3897116_+|DUF4026-domain-containing-protein
MEVQTETYRAAMNGTLERHFSDMIAVIPTRITIEQLKQRLENIATKVDELKIVYSDETSLIVELHMGNKVIPYELHIDETNDPEEYKLYNRQDSTIVDRTFEDAAYGTEIFTRTLFVGDVLDCFFQQLQFLWNLAPDLLFVIDSSAAMKVISRSYIEYHVENELLPDIPDLYVIHSVYEDDKEGEPTQYWFHTHGLLRAGVTEIELIIPNRISSYYGIGDLFQTFANNAVENGQVPMNEPIVIAHSQQGSIHTVAVPWEKGLSYIGHKTSMDQLSSIEDEEVKLQPINAQNTFLGGMDDRDEYHQSPSVLLFKFDTSEEYIESFFKEHEEATGLMFYKTNSETARMAYNAKNTFGYFSNIFQIEQSNEEFRFLAKFGVSYEEGKSEHMWFEMQHITEEFIQGILINEPYFIEDMSEGNSYHLDFDDLTEWVIYAGDAVIKPNNLYMFIGE
>NZ_CP053934.1|WP_042511631.1|3897155_3898577_-|protoporphyrinogen-oxidase
MRKKVVIIGGGITGLTTMYHLQKDIRDKNLPIDTLLIEASGKLGGKIQTVRKDGFTIERGPDSFLARKESAARLVKELGLGDELVNNQAGQSFILVNNRLHKMPSGSMMGIPTQITPFLFSGLFSPIGKLRAGFDLLMPRSKPVSDQSLGHFFRHRLGNEVVENLIEPLLSGIYAGDIDEMSLMSTFPQMYQIEQKHRSISLGMRTLAPKAEKAEPKKGIFQTVKTGLESIVESLELKMHEGMIIKGTRIEKVAKQGDGYAITLSNGKEIEADAVVVASSHKVLPSMFAQYKQFRFFRNIPSTSVANVAMAFPKSAIQRDIDGTGFVVSRNSDYTITACTWTHKKWPHTTPEGKTLLRCYVGRPGDEAVVEQTEEELVQLVLEDLRKTMDITEDPEFTVVSRWKEAMPQYTVGHNERMKKLTTFMEKELPGIYLAGSSYAGSGLPDCIDQGEKAAKRVLSHLEKVMNTELIAQ
>NZ_CP053934.1|WP_000726793.1|3898596_3899532_-|ferrochelatase
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLEDLTERYRAIGGISPLATITLEQAKKLEKRLNEVQDEVEYHMYLGLKHIEPFIEDAVKEMHNDGIQDAIALVLAPHYSTFSVKSYVGRAQEEAEKLGNLTIHGIDSWYKEPKFIQYWVDAVKSIYSGMSDAEREKAVLIVSAHSLPEKIIAMGDPYPDQLNETADYIARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRELNEKYGYTSFVYAPVGFVAEHLEVLYDNDFECKVVTDEIGAKYYRPEMPNASDAFIDCLTDVVVKKKESVM
>NZ_CP053934.1|WP_000252614.1|3899546_3900593_-|uroporphyrinogen-decarboxylase
MVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAILYKDIMSPLPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSRNYHNTKAFMYAEPKAWFALMDKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMIMHGVGAAHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQPGYIFNLGHGVFPEVNPDTLKRLTTFIHEYSKGQLAK
>NZ_CP053934.1|WP_000756262.1|3900772_3902890_-|PBP1A-family-penicillin-binding-protein
MKKVKWTLLGGLATLVLAIVLYKLIVLAGGYMMDEKQLVFHSSSRIVDQKGKEITKLYVENRDLVPIEQIPKYVQQAFVAVEDSRFYEHQGIDYPSIFRALYKDTLAGEKVEGGSTITQQLAKNVFLTREKTFTRKLKEVAISLQLEQKYTKQQILEMYMNHIYFGHGAYGIQAAAKLYFNKNVEDLTVEEGAMLAGLPKSPNGYSPYFSPEKSKERRDLVLSLMHKQGYLTAEESVRYQGKTIALYKNLDENELAYMPYIDMVIDEAARLYGLSHQEVLRGGYTFVVPMDEKIQKVAYNQFQDARNFPGKEEGAQGAFLLMDNRTGGIKAAIGGRKYVPRGFNRVFAKRQPGSVLKPLIVYAPALETKKYNPYSLLTNERHSFEGYEPRNYNREYSKEITMYDAILESANVPAVSLLNELGVEEGKQYLEKGNVHIADAGLSTALGGLKNGVSTFDLVKMYRAFLANGDIIEPHVIDKVLNRHGAVIGESPKVETKIFSKQTAWYMTKMLEGVVKEGTAKAGVYSGALAGKTGTTSLPNDDNGARDMWFVGYTPNLVGAVWIGYDRIDKEHKLQGESASATKLFKKILTKANVEQKEQFRKPEGVETIGAPIRLRKIEDVKMKLAFSPFGLFKAKLSWTPLPDERIMYRIYRVENGIHTHVGTVNGAGEYEEKFVNIFSKPSFYVVPYNTQTNREGEKSKVAKP
>NZ_CP053934.1|WP_042511632.1|3903017_3903521_+|antibiotic-biosynthesis-monooxygenase
MKAIISYETPLEQAHFTAKNNEKDMFYKENTEESVEGSLKYDVLDAVGEFKGQPGYIVCNNISVTDEGRPVFENRFKNRAGLIENEPGFQAIRVLRPLSNDTYVILTMWETEQNFKDWTESRSFENAHKKRPAQAEGQTPSQAHPHAEQQKSIFSRPSFVTTFDVLV

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP053934_1	1.26\|438840\|20\|NZ_CP053934\|CRT	438840-438859	20	NZ_CP053936.1	11740-11759	2	0.9
NZ_CP053934_1	1.26\|438840\|20\|NZ_CP053934\|CRT	438840-438859	20	NZ_CP053933.1	41421-41440	2	0.9

1. spacer 1.26|438840|20|NZ_CP053934|CRT matches to position: 11740-11759, mismatch: 2, identity: 0.9

gcaacaggaagcacaggtcc	CRISPR spacer
gcaacaggaataacaggtcc	Protospacer
**********  ********

2. spacer 1.26|438840|20|NZ_CP053934|CRT matches to position: 41421-41440, mismatch: 2, identity: 0.9

gcaacaggaagcacaggtcc	CRISPR spacer
gcaacaggaataacaggtcc	Protospacer
**********  ********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP053934_1	1.24\|438741\|20\|NZ_CP053934\|CRT	438741-438760	20	NC_012527	Deinococcus deserti VCD115 plasmid 1, complete sequence	137108-137127	1	0.95
NZ_CP053934_1	1.25\|438786\|29\|NZ_CP053934\|CRT	438786-438814	29	MT362618	Microcystis phage MaeS, complete genome	27505-27533	8	0.724

1. spacer 1.24|438741|20|NZ_CP053934|CRT matches to NC_012527 (Deinococcus deserti VCD115 plasmid 1, complete sequence) position: , mismatch: 1, identity: 0.95

aacacgggagcaacaggagc	CRISPR spacer
gacacgggagcaacaggagc	Protospacer
.*******************

2. spacer 1.25|438786|29|NZ_CP053934|CRT matches to MT362618 (Microcystis phage MaeS, complete genome) position: , mismatch: 8, identity: 0.724

agtacgggagtgacaggaagtacaggggc	CRISPR spacer
tcaactggagcgacaggaagtacaggtag	Protospacer
   ** ****.*************** .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1398467 : 1458990

Bacillus_phage(42.22%)

integrase,tRNA,portal,capsid,protease,tail,terminase,head

attL 1404926:1404941|attR 1435651:1435666

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000504940.1\|1398467_1399421_+\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_000813896.1\|1399442_1399667_+	RNA chaperone Hfq	NA	NA	NA	NA
WP_042510921.1\|1399746_1403298_-	Gly-Xaa-Xaa repeat protein	NA	NA	NA	NA
WP_000450309.1\|1403411_1404377_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_042510922.1\|1404490_1405447_+	stage V sporulation protein K	G3MAX6	Bacillus_virus	3.5e-53	44.0
1404926:1404941	attL	NA	NA	NA	NA
WP_000312272.1\|1405716_1406340_-	trimeric intracellular cation channel family protein	NA	NA	NA	NA
WP_000391400.1\|1406432_1407707_+	GTPase HflX	NA	NA	NA	NA
WP_000460319.1\|1407699_1408971_+	methionine gamma-lyase family protein	NA	NA	NA	NA
WP_000656783.1\|1409146_1409536_+	transcriptional repressor GlnR	NA	NA	NA	NA
WP_000135328.1\|1409584_1410919_+	type I glutamate--ammonia ligase	NA	NA	NA	NA
WP_000135915.1\|1411033_1412179_-\|integrase	site-specific integrase	A0A0M5M609	Bacillus_phage	7.4e-66	38.0
WP_042510924.1\|1412220_1412388_-	hypothetical protein	NA	NA	NA	NA
WP_000673782.1\|1412403_1412832_-	ImmA/IrrE family metallo-endopeptidase	Q9T201	Bacillus_phage	2.8e-34	55.1
WP_000060654.1\|1412854_1413268_-	helix-turn-helix transcriptional regulator	A0A0M4QX29	Bacillus_phage	5.1e-25	47.1
WP_000877760.1\|1413543_1413744_+	helix-turn-helix transcriptional regulator	A0A0C5AJQ3	Paenibacillus_phage	1.4e-09	52.6
WP_000572505.1\|1413740_1414469_+	Rha family transcriptional regulator	A0A288WFT2	Bacillus_phage	3.1e-49	48.6
WP_042510925.1\|1414577_1414844_+	group-specific protein	S5MC08	Brevibacillus_phage	1.5e-25	55.8
WP_009879769.1\|1414846_1415005_+	hypothetical protein	NA	NA	NA	NA
WP_000510717.1\|1414994_1415312_+	hypothetical protein	NA	NA	NA	NA
WP_000897921.1\|1415283_1415547_+	hypothetical protein	A0A0M5M3T1	Bacillus_phage	2.9e-10	61.1
WP_042510926.1\|1415561_1416044_+	siphovirus Gp157 family protein	E5DV79	Deep-sea_thermophilic_phage	6.3e-35	48.8
WP_042510927.1\|1416040_1416712_+	DUF1071 domain-containing protein	A0A1B1P7F0	Bacillus_phage	1.4e-27	45.5
WP_000849734.1\|1416725_1416998_+	hypothetical protein	A0A0M4S680	Bacillus_phage	2.9e-37	82.0
WP_000067428.1\|1416994_1417753_+	conserved phage C-terminal domain-containing protein	A0A1W6JNI1	Staphylococcus_phage	3.6e-61	54.9
WP_042510928.1\|1417688_1418519_+	ATP-binding protein	U5PWH5	Bacillus_phage	1.3e-35	38.4
WP_042510929.1\|1418536_1418707_+	hypothetical protein	NA	NA	NA	NA
WP_042510930.1\|1418703_1419333_+	hypothetical protein	A0A0M4RU33	Bacillus_phage	3.7e-27	40.9
WP_000553935.1\|1419335_1419458_+	Fur-regulated basic protein FbpA	NA	NA	NA	NA
WP_042510931.1\|1419552_1420125_+	dUTP diphosphatase	A0A0A7AQI4	Bacillus_phage	7.7e-80	73.8
WP_042510932.1\|1420175_1420649_-	hypothetical protein	NA	NA	NA	NA
WP_080773562.1\|1421023_1421287_-	hypothetical protein	NA	NA	NA	NA
WP_144405033.1\|1421723_1422470_+	FAD-dependent thymidylate synthase	A0A2P1JUN2	Bacillus_phage	8.5e-79	61.7
WP_042510933.1\|1422573_1422786_-	hypothetical protein	NA	NA	NA	NA
WP_000520472.1\|1422922_1423210_+	hypothetical protein	A6M999	Geobacillus_virus	1.9e-34	71.3
WP_042510934.1\|1423214_1423589_+	DUF1492 domain-containing protein	A0A0M4R397	Bacillus_phage	7.1e-42	69.4
WP_042510936.1\|1424062_1424314_+	helix-turn-helix domain-containing protein	A0A2H4JDR0	uncultured_Caudovirales_phage	2.2e-15	51.9
WP_042510937.1\|1424380_1424605_+	hypothetical protein	NA	NA	NA	NA
WP_052495361.1\|1424745_1426107_+	DUF4935 domain-containing protein	NA	NA	NA	NA
WP_042510938.1\|1426662_1427166_+	sigma-70 family RNA polymerase sigma factor	A0A1L2JY33	Aeribacillus_phage	3.6e-57	66.5
WP_042510939.1\|1427363_1429313_+	AAA family ATPase	NA	NA	NA	NA
WP_042510940.1\|1429299_1430490_+	hypothetical protein	NA	NA	NA	NA
WP_042510941.1\|1430538_1431183_-	HNH endonuclease	NA	NA	NA	NA
WP_042510942.1\|1431323_1431656_+	nucleotide pyrophosphohydrolase	NA	NA	NA	NA
WP_042510943.1\|1431688_1432672_+	HNH endonuclease	NA	NA	NA	NA
WP_042510945.1\|1433275_1433554_+	helix-turn-helix domain-containing protein	A0A2H4JBQ8	uncultured_Caudovirales_phage	1.5e-09	43.2
WP_042510946.1\|1433674_1434100_+	hypothetical protein	NA	NA	NA	NA
WP_042510947.1\|1434186_1434609_-	type II toxin-antitoxin system HicB family antitoxin	A0A1L2JY34	Aeribacillus_phage	3.4e-40	58.3
WP_000352022.1\|1434880_1435042_-	hypothetical protein	NA	NA	NA	NA
WP_001051273.1\|1435374_1435671_+	HNH endonuclease	R9TNN2	Paenibacillus_phage	7.8e-28	60.4
1435651:1435666	attR	NA	NA	NA	NA
WP_042510948.1\|1435837_1436209_+	hypothetical protein	A0A2H4J5M7	uncultured_Caudovirales_phage	3.3e-15	41.8
WP_042510949.1\|1436205_1437894_+\|terminase	terminase large subunit	A0A290GJW3	Caldibacillus_phage	2.6e-253	73.4
WP_042510950.1\|1437909_1439121_+\|portal	phage portal protein	J9QE83	Clostridium_phage	2.6e-138	59.9
WP_001043897.1\|1439086_1439671_+\|head,protease	HK97 family phage prohead protease	A0A2I7SBY1	Paenibacillus_phage	1.0e-39	50.5
WP_000854837.1\|1439684_1440848_+\|capsid	phage major capsid protein	H7BUQ0	unidentified_phage	3.2e-80	54.7
WP_042510951.1\|1440884_1441175_+	hypothetical protein	A6XMJ7	Bacillus_virus	4.8e-06	37.0
WP_042510952.1\|1441177_1441450_+	DNA-packaging protein	R9TMB7	Paenibacillus_phage	1.5e-20	58.4
WP_000997895.1\|1441446_1441746_+\|head	phage head closure protein	R9TPZ2	Paenibacillus_phage	1.7e-09	38.3
WP_042510953.1\|1441738_1442095_+	HK97 gp10 family phage protein	D2XR21	Bacillus_phage	5.3e-31	60.3
WP_000172073.1\|1442091_1442421_+	hypothetical protein	A0A2H4JAG4	uncultured_Caudovirales_phage	2.2e-47	83.5
WP_001293690.1\|1442421_1443015_+\|tail	phage tail protein	A0A2H4JDV4	uncultured_Caudovirales_phage	5.3e-92	84.1
WP_000415946.1\|1443019_1443382_+	hypothetical protein	A0A2H4JAG8	uncultured_Caudovirales_phage	9.2e-47	74.8
WP_000477711.1\|1443435_1443597_+	hypothetical protein	A0A2H4JHE4	uncultured_Caudovirales_phage	2.0e-22	94.3
WP_052495362.1\|1445079_1447509_+	hypothetical protein	D2XR26	Bacillus_phage	9.4e-10	61.9
WP_042510955.1\|1447550_1449032_+\|tail	phage tail family protein	A0A1B1P7W7	Bacillus_phage	2.9e-240	79.5
WP_042510956.1\|1449028_1453906_+\|tail	phage tail protein	A0A2H4JF18	uncultured_Caudovirales_phage	9.0e-312	46.1
WP_000077308.1\|1453923_1454199_+	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	A0A1B1P7E8	Bacillus_phage	6.8e-34	78.8
WP_000398741.1\|1454309_1454546_+	hemolysin XhlA family protein	A0A2H4J382	uncultured_Caudovirales_phage	1.9e-16	92.3
WP_000461736.1\|1454545_1454785_+	hypothetical protein	A0A0A7AR38	Bacillus_phage	4.0e-30	84.8
WP_042510957.1\|1454781_1455837_+	N-acetylmuramoyl-L-alanine amidase	A0A1C8E990	Bacillus_phage	4.5e-158	75.5
WP_052495363.1\|1456005_1457319_+	hypothetical protein	NA	NA	NA	NA
WP_158333830.1\|1457296_1457455_+	hypothetical protein	NA	NA	NA	NA
WP_042510958.1\|1457627_1458227_-	hypothetical protein	A6XML2	Bacillus_virus	3.9e-26	48.6
WP_000383886.1\|1458389_1458542_+	hypothetical protein	NA	NA	NA	NA
WP_042510959.1\|1458777_1458990_+	transcriptional regulator	A0A1Z1LZP5	Bacillus_phage	2.4e-18	68.6

DBSCAN-SWA_2

3126437 : 3135164

Bacillus_phage(71.43%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_042511451.1\|3126437_3127310_-	aminoglycoside 6-adenylyltransferase	A0A1X9I6F2	Streptococcus_phage	3.9e-67	46.2
WP_002036196.1\|3127450_3127564_-	hypothetical protein	W8CYT3	Bacillus_phage	2.1e-05	91.7
WP_000818985.1\|3127680_3128400_-	3-ketoacyl-ACP reductase	W8CYX9	Bacillus_phage	5.9e-61	100.0
WP_042511453.1\|3128595_3129183_+	DUF3139 domain-containing protein	NA	NA	NA	NA
WP_042511454.1\|3129207_3130275_-	HAMP domain-containing sensor histidine kinase	W8CYF6	Bacillus_phage	3.1e-167	88.0
WP_170924614.1\|3130271_3130976_-	response regulator	W8CYM9	Bacillus_phage	4.2e-120	93.2
WP_042511455.1\|3131037_3132798_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	3.1e-265	95.3
WP_001194297.1\|3133038_3133803_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_000755546.1\|3133901_3135164_-	C40 family peptidase	A0A1V0DZX6	Clostridioides_phage	6.8e-12	32.0

DBSCAN-SWA_3

4618859 : 4627236

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000088592.1\|4618859_4619447_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.2e-27	37.1
WP_001262436.1\|4619443_4620484_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	9.4e-68	46.4
WP_000879029.1\|4620590_4622006_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	7.3e-55	35.4
WP_000055577.1\|4621990_4624210_-	phosphoribosylformylglycinamidine synthase II	A6N228	Microbacterium_phage	1.7e-162	41.2
WP_000666779.1\|4624193_4624877_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_000278820.1\|4624873_4625128_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_001170542.1\|4625120_4625840_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	G8EYA2	Synechococcus_phage	5.2e-49	44.3
WP_000625683.1\|4625928_4627236_-	adenylosuccinate lyase	A0A2H4UUU6	Bodo_saltans_virus	6.4e-21	25.3

DBSCAN-SWA_4

4665075 : 4673025

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000719243.1\|4665075_4666581_-	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	9.2e-32	30.8
WP_000929888.1\|4666564_4667266_-	response regulator transcription factor	W8CYM9	Bacillus_phage	7.3e-40	36.9
WP_042511771.1\|4667411_4668737_-	NCS2 family permease	A0A0R6PHV4	Moraxella_phage	2.1e-43	29.2
WP_162837124.1\|4669121_4670663_-	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	3.4e-21	31.2
WP_001029999.1\|4671067_4672702_-	chaperonin GroEL	A0A219YK78	uncultured_virus	2.0e-157	58.2
WP_000917306.1\|4672740_4673025_-	co-chaperone GroES	A0A221S3C8	uncultured_virus	1.2e-20	53.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP053936

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

2. NZ_CP053933

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

3. NZ_CP053934

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection