CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP046113	Enterococcus faecalis strain 092160007-3 chromosome, complete genome	3 crisprs	csa3,cas3,cas14j,DinG,csn2,cas2,cas1,cas9,DEDDh,RT	0	16	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP046113_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046113_1

1459041-1460000

TypeII

Consensus_repeat	Method
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	PILER-CR
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	CRISPRCasFinder
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	CRT

14 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of NZ_CP046113_1

>merge|NZ_CP046113|1|1459041-1460000|PILER-CR,CRISPRCasFinder,CRT
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAACAATTTCAGATTACGAATTAACAGAAATAAAGTTTTACTGATAAGAAATTATTGAGAATACAAAAACATGGGTGGACCAACGATTCACAGTTCCGCAGTTTTACTGATAAGAAATTATTGAGAGTACAAAAACGCTTCGGCAATGGTTACATCAGCAGTTAAAGTTTTACTGATAAGAAATTATTGAGAGTACAAAAACCTACCTGCATTTTTAAAGGAATGAGCGTGGGTTTTACTGATAAGAAATTATTGAGAGTACAAAAACATTATCAGATGCTAAACGTAATGCAGATTGGTTTTACTGATAAGAAATTATTGAGAGTACAAAAACTGCGGTTAAAGCAAGCGATTCGGATATATAGTTTTACTGATAAGAAATTATTGAGAGTACAAAAACCAGAGTTTCAAGAGCTGCATGAATTATTCGGTTTTACTGATAAGAAATTATTGAGAGTACAAAAACTAACGAAGGGTGTAGGATTTTTAGGCAAGGGTTTTACTGATAAGAAATTATTGAGAGTACAAAAACAGCCAAGATTGAAGATAGAGGTCTCTTTCAGTTTTACTGATAAGAAATTATTGAGAGTACAAAAACAATCTTCTCATTTGTATTCCTCCAAAAGCAGTTTTACTGATAAGAAATTATTGAGAGTACAAAAACTGTAATTAGAAGAATAAAGAGCTGTATCGGGTTTTACTGATAAGAAATTATTGAGAGTACAAAAACCTTTCAAAAGAAAATAATTGATTCAATTGAGTTTTACTGATAAGAAATTATTGAGAGTACAAAAACTCGTCTGTGCGCCGAATAGATAAAGAGGTGGTTTTACTGATAAGAAATTATTGAGAGTACAAAAACAATAGATGGGTAAGAACTGTTTATGTCAAAGTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC

>NZ_CP046113|1|1|1459041-1460000|PILER-CR
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	AATTTCAGATTACGAATTAACAGAAATAAA
GTTTTACTGATAAGAAATTATTGAGAATACAAAAAC	ATGGGTGGACCAACGATTCACAGTTCCGCA
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	GCTTCGGCAATGGTTACATCAGCAGTTAAA
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	CTACCTGCATTTTTAAAGGAATGAGCGTGG
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	ATTATCAGATGCTAAACGTAATGCAGATTG
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	TGCGGTTAAAGCAAGCGATTCGGATATATA
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	CAGAGTTTCAAGAGCTGCATGAATTATTCG
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	TAACGAAGGGTGTAGGATTTTTAGGCAAGG
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	AGCCAAGATTGAAGATAGAGGTCTCTTTCA
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	AATCTTCTCATTTGTATTCCTCCAAAAGCA
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	TGTAATTAGAAGAATAAAGAGCTGTATCGG
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	CTTTCAAAAGAAAATAATTGATTCAATTGA
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	TCGTCTGTGCGCCGAATAGATAAAGAGGTG
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	AATAGATGGGTAAGAACTGTTTATGTCAAA
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC

>NZ_CP046113|1|1|1459041-1460000|CRISPRCasFinder
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	AATTTCAGATTACGAATTAACAGAAATAAA
GTTTTACTGATAAGAAATTATTGAGAATACAAAAAC	ATGGGTGGACCAACGATTCACAGTTCCGCA
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	GCTTCGGCAATGGTTACATCAGCAGTTAAA
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	CTACCTGCATTTTTAAAGGAATGAGCGTGG
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	ATTATCAGATGCTAAACGTAATGCAGATTG
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	TGCGGTTAAAGCAAGCGATTCGGATATATA
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	CAGAGTTTCAAGAGCTGCATGAATTATTCG
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	TAACGAAGGGTGTAGGATTTTTAGGCAAGG
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	AGCCAAGATTGAAGATAGAGGTCTCTTTCA
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	AATCTTCTCATTTGTATTCCTCCAAAAGCA
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	TGTAATTAGAAGAATAAAGAGCTGTATCGG
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	CTTTCAAAAGAAAATAATTGATTCAATTGA
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	TCGTCTGTGCGCCGAATAGATAAAGAGGTG
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	AATAGATGGGTAAGAACTGTTTATGTCAAA
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC

>NZ_CP046113|1|1|1459041-1460000|CRT
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	AATTTCAGATTACGAATTAACAGAAATAAA
GTTTTACTGATAAGAAATTATTGAGAATACAAAAAC	ATGGGTGGACCAACGATTCACAGTTCCGCA
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	GCTTCGGCAATGGTTACATCAGCAGTTAAA
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	CTACCTGCATTTTTAAAGGAATGAGCGTGG
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	ATTATCAGATGCTAAACGTAATGCAGATTG
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	TGCGGTTAAAGCAAGCGATTCGGATATATA
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	CAGAGTTTCAAGAGCTGCATGAATTATTCG
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	TAACGAAGGGTGTAGGATTTTTAGGCAAGG
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	AGCCAAGATTGAAGATAGAGGTCTCTTTCA
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	AATCTTCTCATTTGTATTCCTCCAAAAGCA
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	TGTAATTAGAAGAATAAAGAGCTGTATCGG
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	CTTTCAAAAGAAAATAATTGATTCAATTGA
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	TCGTCTGTGCGCCGAATAGATAAAGAGGTG
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC	AATAGATGGGTAAGAACTGTTTATGTCAAA
GTTTTACTGATAAGAAATTATTGAGAGTACAAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046113.1\|WP_002357293.1\|1472121_1472673_-\|ribosome-associated-translation-inhibitor-RaiA	unknown	unknown	gnl\|CDD\|224461
NZ_CP046113.1\|WP_002357302.1\|1455159_1455969_-\|phosphate-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|237646
NZ_CP046113.1\|WP_002357300.1\|1455985_1456870_-\|phosphate-ABC-transporter-permease-PstA	unknown	unknown	gnl\|CDD\|223654
NZ_CP046113.1\|WP_002357307.1\|1451135_1451492_-\|phage-holin-family-protein	unknown	unknown	gnl\|CDD\|377198
NZ_CP046113.1\|WP_002357305.1\|1451889_1453491_-\|daptomycin-sensing-surface-protein-LiaX	unknown	unknown	gnl\|CDD\|226123
NZ_CP046113.1\|WP_168354140.1\|1454390_1455242_-\|phosphate-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|172743
NZ_CP046113.1\|WP_002397366.1\|1461135_1461435_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NZ_CP046113.1\|WP_111997025.1\|1468150_1469252_-\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799
NZ_CP046113.1\|WP_002357306.1\|1451491_1451815_-\|PspC-domain-containing-protein	unknown	unknown	gnl\|CDD\|377200
NZ_CP046113.1\|WP_016633925.1\|1462581_1466034_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187774
NZ_CP046113.1\|WP_016633924.1\|1461455_1462376_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|274694
NZ_CP046113.1\|WP_002357304.1\|1453698_1454376_-\|phosphate-signaling-complex-protein-PhoU	unknown	unknown	gnl\|CDD\|273990
NZ_CP046113.1\|WP_025193493.1\|1456869_1457790_-\|phosphate-ABC-transporter-permease-subunit-PstC	unknown	unknown	gnl\|CDD\|223646
NZ_CP046113.1\|WP_002379511.1\|1472811_1473498_-\|ComF-family-protein	unknown	unknown	gnl\|CDD\|223970
NZ_CP046113.1\|WP_002357298.1\|1457912_1458767_-\|phosphate-ABC-transporter-substrate-binding-protein-PstS	unknown	unknown	gnl\|CDD\|273991
NZ_CP046113.1\|WP_002381826.1\|1469328_1471866_-\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NZ_CP046113.1\|WP_002379508.1\|1460077_1461136_-\|hypothetical-protein	csn2	cd12217_csn2_CAS-II-A	gnl\|CDD\|213410
NZ_CP046113.1\|WP_002361935.1\|1467358_1468045_-\|cell-division-ATP-binding-protein-FtsE	unknown	unknown	gnl\|CDD\|225438
NZ_CP046113.1\|WP_016633920.1\|1450138_1451101_+\|GIY-YIG-nuclease-family-protein	unknown	unknown	gnl\|CDD\|234792
NZ_CP046113.1\|WP_002364071.1\|1466481_1467366_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|225088

Protein	Function_ID	Function_description	E-value
NZ_CP046113.1\|WP_002357293.1\|1472121_1472673_-\|ribosome-associated-translation-inhibitor-RaiA	gnl\|CDD\|224461	COG1544, COG1544, Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis].	9.1271e-38
NZ_CP046113.1\|WP_002357302.1\|1455159_1455969_-\|phosphate-ABC-transporter-ATP-binding-protein	gnl\|CDD\|237646	PRK14237, PRK14237, phosphate transporter ATP-binding protein; Provisional.	0
NZ_CP046113.1\|WP_002357300.1\|1455985_1456870_-\|phosphate-ABC-transporter-permease-PstA	gnl\|CDD\|223654	COG0581, PstA, ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism].	1.01734e-103
NZ_CP046113.1\|WP_002357307.1\|1451135_1451492_-\|phage-holin-family-protein	gnl\|CDD\|377198	pfam04020, Phage_holin_4_2, Mycobacterial 4 TMS phage holin, superfamily IV. These proteins are predicted transmembrane proteins with probably four transmembrane spans. The 1.E.40 is represented by the mycobacterial 4 phage holin, but it also contains many cyanobacterial. proteobacterial and firmicute proteins. Holins are encoded within the genomes of Gram-positive and Gram-negative bacteria as well as in those of the bacteriophage of these organisms. The primary function of holins appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis. When chromosomally encoded the enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some may catalyze export of nucleases.	7.53845e-22
NZ_CP046113.1\|WP_002357305.1\|1451889_1453491_-\|daptomycin-sensing-surface-protein-LiaX	gnl\|CDD\|226123	COG3595, COG3595, Uncharacterized conserved protein [Function unknown].	6.33034e-14
NZ_CP046113.1\|WP_168354140.1\|1454390_1455242_-\|phosphate-ABC-transporter-ATP-binding-protein	gnl\|CDD\|172743	PRK14255, PRK14255, phosphate ABC transporter ATP-binding protein; Provisional.	0
NZ_CP046113.1\|WP_002397366.1\|1461135_1461435_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	8.28523e-23
NZ_CP046113.1\|WP_111997025.1\|1468150_1469252_-\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
NZ_CP046113.1\|WP_002357306.1\|1451491_1451815_-\|PspC-domain-containing-protein	gnl\|CDD\|377200	pfam04024, PspC, PspC domain. This family includes Phage shock protein C (PspC) that is thought to be a transcriptional regulator. The presumed domain is 60 amino acid residues in length.	1.24173e-20
NZ_CP046113.1\|WP_016633925.1\|1462581_1466034_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|187774	cd09643, Csn1, CRISPR/Cas system-associated protein Cas9. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Very large protein containing McrA/HNH-nuclease related domain and a RuvC-like nuclease domain; signature gene for type II.	1.3796e-115
NZ_CP046113.1\|WP_016633924.1\|1461455_1462376_-\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274694	TIGR03639, cas1_NMENI, CRISPR-associated endonuclease Cas1, subtype II/NMENI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.	9.75664e-98
NZ_CP046113.1\|WP_002357304.1\|1453698_1454376_-\|phosphate-signaling-complex-protein-PhoU	gnl\|CDD\|273990	TIGR02135, Uncharacterized_protein, phosphate transport system regulatory protein PhoU. This model describes PhoU, a regulatory protein of unknown mechanism for high-affinity phosphate ABC transporter systems. The protein consists of two copies of the domain described by pfam01895. Deletion of PhoU activates constitutive expression of the phosphate ABC transporter and allows phosphate transport, but causes a growth defect and so likely has some second function. [Regulatory functions, Other, Transport and binding proteins, Anions].	6.09767e-88
NZ_CP046113.1\|WP_025193493.1\|1456869_1457790_-\|phosphate-ABC-transporter-permease-subunit-PstC	gnl\|CDD\|223646	COG0573, PstC, ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism].	2.25121e-99
NZ_CP046113.1\|WP_002379511.1\|1472811_1473498_-\|ComF-family-protein	gnl\|CDD\|223970	COG1040, ComFC, Predicted amidophosphoribosyltransferases [General function prediction only].	4.80637e-34
NZ_CP046113.1\|WP_002357298.1\|1457912_1458767_-\|phosphate-ABC-transporter-substrate-binding-protein-PstS	gnl\|CDD\|273991	TIGR02136, ptsS_2, phosphate binding protein. Members of this family are phosphate-binding proteins. Most are found in phosphate ABC-transporter operons, but some are found in phosphate regulatory operons. This model separates members of the current family from the phosphate ABC transporter phosphate binding protein described by TIGRFAMs model TIGR00975. [Transport and binding proteins, Anions].	3.17732e-122
NZ_CP046113.1\|WP_002381826.1\|1469328_1471866_-\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NZ_CP046113.1\|WP_002379508.1\|1460077_1461136_-\|hypothetical-protein	gnl\|CDD\|213410	cd12217, Stu0660_Csn2, Stu0660-like CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. This family of Csn2 proteins includes Stu0660, the proteins are larger than other (canonical) Csn2 proteins as they have an additional alpha-helical C-terminal domain. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	6.00722e-114
NZ_CP046113.1\|WP_002361935.1\|1467358_1468045_-\|cell-division-ATP-binding-protein-FtsE	gnl\|CDD\|225438	COG2884, FtsE, Predicted ATPase involved in cell division [Cell division and chromosome partitioning].	1.10484e-139
NZ_CP046113.1\|WP_016633920.1\|1450138_1451101_+\|GIY-YIG-nuclease-family-protein	gnl\|CDD\|234792	PRK00558, uvrC, excinuclease ABC subunit UvrC.	1.35853e-45
NZ_CP046113.1\|WP_002364071.1\|1466481_1467366_-\|ABC-transporter-permease	gnl\|CDD\|225088	COG2177, FtsX, Cell division protein [Cell division and chromosome partitioning].	4.28311e-97

>NZ_CP046113.1|WP_002357298.1|1457912_1458767_-|phosphate-ABC-transporter-substrate-binding-protein-PstS
MKKRLLLFIGLASILTLTGCAKWIDRGESITAVGSSALQPLVETASEEYQSQNPGRFINVQGGGSGTGLSQVQSGAVDIGNSDLFAEEKKGIKAEDLIDHKVAVVGITPIVNKNVGVKDISMENLKKIFLGEVTNWKELGGKDQKIVILNRAAGSGTRATFEKWVLGDKTAIRAQEQDSSGMVRSIVSDTPGAISYTAFSYVTDEVATLSIDGVQPTDENVMNNKWIIWSYEHMYTRKNPSDLTKEFLDFMLSDDIQERVIGQLGYIPVSKMEIERDWQGNVIK
>NZ_CP046113.1|WP_025193493.1|1456869_1457790_-|phosphate-ABC-transporter-permease-subunit-PstC
MEDVQKKLLTKSKRAKMEQRGKFISFLCIALIVAVVVSIFYFVASKGLATFFKDKINVLDFLFGTNWNPSDIGADGKPMVGALPMIAGSFIVTFLSAIVATPFAIGAAVFMTEISPKKGAKFLQPVIELLVGIPSVVYGFIGLSVIVPFVRSIFGGTGFGILAGTFVLFVMILPTVTTMTVDALKAVPRHYREASLALGATRWQTIYKVVLRAAVPGILTAVVFGMARAFGEALAIQMVIGNAAVMPTSLTTPASTLTSILTMGIGNTIMGTVENNVLWSLALILLLMSLLFNIVIRIIGKRGALK
>NZ_CP046113.1|WP_002357300.1|1455985_1456870_-|phosphate-ABC-transporter-permease-PstA
MNAKKADKIATGILYAVSGVIVLILAALLIYILARGIPHISWEFLTQPSRAYQVGGGIGIQLFNSLYLLLITMIISIPISLGAGIYLSEYAKKNWLTDLIRTSIEILSSLPSVVVGLFGFLIFVVQIGYGFSILSGALALTFFNLPLLTRNVEESLKAIHYTQREAGLALGLSRWETVKKVILPEALPGILTGVILSSGRIFGEAAALIYTAGQSAPALDFSNWNPLSVSSPISIFRQAETLAVHIWKINTEGTMPDGAAVSAGASAVLILVVLLFNFGARFIGNRLYKRMTSA
>NZ_CP046113.1|WP_002357302.1|1455159_1455969_-|phosphate-ABC-transporter-ATP-binding-protein
MKEYNLNDTHLLQLDSQKDPIALHTEDLHVFYGDNEAIKGVDLQFEKNKITALIGPSGCGKSTYLRSLNRMNDGIANSRVTGKIMYKDVDVNTKEVDVYEMRKRIGMVFQRPNPFSKSIYENITFALKQHGEKDKKKLDEIVETSLKQAALWDQVKDNLNKSALALSGGQQQRLCIARAIAMKPDILLLDEPASALDPISTGTVEETLVNLKDDYTIIIVTHNMQQAARISDYTAFFYMGKVIEYDHTRKIFTRPKIQATEDYVSGHFG
>NZ_CP046113.1|WP_168354140.1|1454390_1455242_-|phosphate-ABC-transporter-ATP-binding-protein
MNTIIQEKSLHDQKFKQRKTTFQDILVRRSKMGKEIISSKDLHLYYGKKEALKGIDLTFNQGELTAMIGPSGCGKSTYLRCLNRMNDLIPDVTITGSVVYKGKDIYGPKTDNVELRKEIGMVFQQPNPFPFSVYENVIYGLRLKGVKDKQVLDEAVETSLKAAAVWEDVKDKLHKSALSLSGGQQQRVCIARVLAVEPDIILLDEPTSALDPVSSGKIENMLLTLKEKYTMIMVTHNMSQASRISDKTAFFLQGDLIEFNDTKKVFLNPKEKQTEDYISGKFG
>NZ_CP046113.1|WP_002357304.1|1453698_1454376_-|phosphate-signaling-complex-protein-PhoU
MLRTQFEEELLNLHNQFYEMGMMVSSAVHKSVKAYINHDKKLAQEVIDRDIEINDMEVKLEKKSFEMIALQQPVTTDLRMIITVMKASSDLERMADHAVSIAKSTIRLKGETRIPEIEKEISDMSDYVKKMVDNVLIAYVKTDQKDARMIAQMDDRTNEYFDSIYKHAVEAMKANPETVISGTDYLHVAQYLERIGDYVTNICEWIVYLATGKITELNSNRDEQF
>NZ_CP046113.1|WP_002357305.1|1451889_1453491_-|daptomycin-sensing-surface-protein-LiaX
MKERERVLELVKKGILTSEEALILLENMATEKDEKQIEKAAEKVDTQNIGTTNKEDQVADLMDALEKGESEGPTVDSFEENKQDSAEKDRENLERILDELATKANRASAELDEVNAEIAGIKEEIKEVAEEIGTLDTKEELDALTEDEQVQRKDLHVLLAQLEEKLATQSTEKTALEEELKNIRKEQWKGQWNDTKEKVSSQFSEEWKDQATDTFNQVGGKVAEVGGQVGEFLKKTFNSFSDTMNDNVEWKDIKMKVPGVATTKFEHEFNYPNPQASLIDVKVANGTVVFKTWDQEDVKVEAKIKLYGKMAGDSPMEAFLERSDIDVDDETISFQVPNKRVKADLTFYLPKRTYDHVSVKLLNGNVLVEELTAKDVYTKSTNGTITFKKIDATMLEIEGVNGEIKVLEGTILDNIIETVNGDVSISAAPESLSVSLINGDIRITAKEKTLRRVEASSANGNIKLALPNDLGVEGQVKTNLGSINSRLTDIEVVREKKDRGNQQLHFRRVLEESMAQINASTTTGSIFLKDTDK
>NZ_CP046113.1|WP_002357306.1|1451491_1451815_-|PspC-domain-containing-protein
MKRKLTKSPNNVVLTGSLAGIADWLGIDPTIIRVVYVLLSFFSAGFPGILLYIALAVLIPSGRTGSDRGYGHQNPYNRNVRNENPYAANKKQRKEAEKIDDDEWSDF
>NZ_CP046113.1|WP_002357307.1|1451135_1451492_-|phage-holin-family-protein
MTYFQRLVVNTLTFISLSVVFPGMIHVRGIMPAIIAAFVLSILNMLVKPVLTILSLPFTLLTFGLFSFVVNAAILQMTSFFVGEMNFGFSSFWAAVLMAVIMSIVNTIVTDHNLSKYE
>NZ_CP046113.1|WP_016633920.1|1450138_1451101_+|GIY-YIG-nuclease-family-protein
MKEYLKEKAHQLPLTPGVYLMKDATDTIIYVGKAKKLKNRVSSYFINSNQHSRKTMRLVKQIIDFDVLHTDTELDALLLECQLIQQYRPRYNRQMNAYEQYSYVSVAVNERQLEIKLLNIPTKENCFGPYSIRRKLNRLKIILDSIYDLVPTNYWHQTFQKESAIPTELFQQELFDFFHNQGREPIKRIAQQMQEAAEKQAFEKAAKLKEDWLFLTRFANQNQRISQANQRDWQLMWLPCQKKIKYYLIYQGLVVATRVVTKQTFQKYPPLELAKKIMPKKPPKTIEHYSKQQVDFLNILYGYISRHPECHLENLTIEKA
>NZ_CP046113.1|WP_002379508.1|1460077_1461136_-|hypothetical-protein
MKQIRLEYQYQQFIEFSLEDYVFFYGGENQWRRKILRTLKRFAKQKALSDLEESVYGDNGIEIFLEEKKLKAKSIDFYFLEDNTSIFQQMNFIKGTLLHQELLYLQDDFDITNQMSNLNDQLLKLENLMNDKLNNYLTNIEPHFLEMNFQDILKYSLSLNYLENGQSLPLEMMDTRELLAEFIYLLQRSISRREQPVWLVITNPESFLETESIYYLFQQLKKLAQETKQLKFFIFSNRSLPLPYTEEDVEKTILLYDKYQQLPVFDVFRQSIERHYPDQLSWTNQQLIDAFYRVCHFVGDQYTKNYLLPKDMILLKLLKELLDDNSECVETSMEKLTVLEEQYFRERLLRKE
>NZ_CP046113.1|WP_002397366.1|1461135_1461435_-|CRISPR-associated-endonuclease-Cas2
MCLFDLPFETKQEQKEYRIFRKHLLENGFIMLQYSIYYRSLPNRSALKKYETILKRKVPRSGNVRLLYVSEIQFQDMLLLAGSRSHQEEVVGVHRLVVI
>NZ_CP046113.1|WP_016633924.1|1461455_1462376_-|type-II-CRISPR-associated-endonuclease-Cas1
MLLGFRTVFVKNGEKLKVKLDNLEVIKEGNTYVIPLTDIESVILEGDQTVITTRLLAKFAQHHIDTVICDNTFMPVGVFLGIGQYHRSAKRAIWQSNWTEEHKQVAWCEIVTQKIQNQIAVAKYLGTDSERVEVLEKLSEGILPGDTTNREGHVAKVYFHSLYGVGFTREEECLPNACMNYGYAVIRAQMARCVVALGLLPMLGIFHKNEYNSFNLVDDLMEPFRPLMDWYIHQTILKKNEKYLTYHSRLTLVEFLHQKIKVKNKKIYMNQAMSEYVAAFVKAMETGDFENVQKIHLVNMLECEGK
>NZ_CP046113.1|WP_016633925.1|1462581_1466034_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MYSIGLDLGISSVGWSVIDERTGNVIDLGVRLFSAKNSEKNLERRTNRGGRRLIRRKTNRLKDAKKILAAVGFYEDKSLKNSCPYQLRVKGLTEPLSKGEIYKVTLHILKKRGISYLDEDDTEAAKESQDYKEQVRENAQLLTKYTPGQIQLQRLKENNRVKTGINAQGNYQLNVFKVSAYANELATILKTQQAFYPNELTDDWIALFVQPGIAEEAGLIYRKRPYYHGPGNEANNSPYGRWSDFKKTGQPATNIFDKLIGKDFQGELRASGLSLSAQQYNLLNDLTNLKIDGEIPLSPEQKEYILAELMTKEFTRFGVNDVVKLLGVKKERLSGWRLDKKGKPEIHTLKGYRNWRKIFAESGIDLAMLPTETIDCLAKVLTLNTEREGIENTLAFELPELAESVKLLVLDRYKELSQSVSTQAWHRFSLKTLHLLIPELMNATSEQNTLLEQFQLKSDVRKRYSEYKKLPTKDVLTEIYNPTVNKTVSQAFKVIDALLVKYGKEQIRYITIEMPRDDNEEDEKKRIKELHAKNSQRKNDSQSYFMQKSGWSQEKFQTTIQKNRRFLAKLLYYYEQDGICAYTGLSISPELLVSDSTEIDHIIPISISLDDSINNKVLVLSKANQVKGQQTPYDAWMDGSFKKINGKFSNWDDYQKWVESRHFSHKKENNLLETRNIFDSEQVEKFLARNLNDTRYASRLVLNTLQSFFANQETKVRVVNGSFTHTLRKKWGADLDKTRETHHHHAVDATLCAVTPFVKVSRYHYAVKEETGEKVMREIDFETGEIVDEMSYREFKKSKKYERKTYQVKWPNFREQLKPVNLHPRIKFSHQVDRKANRKLSDATIYSVREKTEVKTLKSGKQKITTDEYTIGKIKDIYTVDGWEAFKKKQDKLLMKDLDEKTYERLLSIAETTPDFQEVEEKNGKVKRVKRSPFAVYCEENDIPAIRKYAKKNNGPLIRSLKYYDGKLNKHINITKDSQGRPVEKTKNGRKVTLQSLKPYRYDIYQDLETKAYYTVQLYYSDLRFVEGKYGITEKEYMKKVAEQTKGQVVRFCFSLQKNDGLEIEWKDSQRYDVRFYNFQSANSINFKGLEQEMMPAENQFKQKPYNNGAINLNIAKYGKEGKKLRKFNTDILGKKHYLYYEKEPKNIIK
>NZ_CP046113.1|WP_002364071.1|1466481_1467366_-|ABC-transporter-permease
MIRTFFSHLFESIKSLKRNGWMTVASASAVTITLVLVGIFMGVIFNATKLADDIEKNVTVSVFVDIGTKQNEMKTLEKQLKGLDNVEDISYSNKDQQLKKIQEQMGDAWNLFEGDSNPLYDVYYVRAKTPEDTKDIAKQAAKFPSVFKADYGGVNSDKIFKIAQTVRTWGLAAAALLLFVAVFLISNTIRITILSRQKEIQIMRLVGAKNSFIRWPFFLEGAWIGLIGAIVPVIIMTLGYHQVYNMFNPQLLRSNYSLIRPEDFIWKVNLLMIATGMIIGSLGSVISMRRFLKI
>NZ_CP046113.1|WP_002361935.1|1467358_1468045_-|cell-division-ATP-binding-protein-FtsE
MIEMKDVMKKYSNGTTAIRNISVEIDQGEFVYVVGPSGAGKSTFIRLMYREEKATKGNLTVAGHDLMKIKNKEVPYLRREIGIVFQDYKLLPKKTVYENVAYAMQVIGRRPREIKKRVMEVLDLVGLKHKVRVFPSELSGGEQQRVSIARAIVNTPKVLIADEPTGNLDPENSWEIMKLLDRINAQGTTVVMATHNSTIVNTIRHRVIAIENGRIIRDQVEGEYGYDD
>NZ_CP046113.1|WP_111997025.1|1468150_1469252_-|peptide-chain-release-factor-2
MENPEIRTLLDEMTQKITSFRRSLDLDQLEEDIAEAENRMGEPGFWDNTETAQKLINETNSLKEKYQQFHQLSEELDELTVMFELQQEEYDAEIQEELEERIHLLQERLTTYELSLLLNEPYDHNNALIELHPGAGGTESQDWGSMLLRMYTRWAESHGFQVETLDYQAGDEAGIKSVTLLIKGYNAYGYLKSEKGVHRLVRISPFDSAKRRHTSFCSVDVMPELDDTIEIAINPDDLKIDTYRASGAGGQHINKTESAVRITHIPTGTVVASQAQRSQLKNREQAMSMLKAKLYQLEMEKKAQEAASLRGEQMEIGWGSQIRSYVFHPYSMVKDHRTNYETGNVQAVMDGDLDGFIDAYLKQRLS
>NZ_CP046113.1|WP_002381826.1|1469328_1471866_-|preprotein-translocase-subunit-SecA
MANFLKKMIENDKKELRRLEKIADKIDAHASAMEQLSDEQLREKTDEFKARYQKGETLDELLPEAFAVVREAAKRVLGLFPYRVQLMGGIVLHDGNIPEMRTGEGKTLTATMPVYLNALSGEGVHVVTVNEYLATRDSNEMGELYNFLGLSVGLNINSKSSDEKREAYNCDITYSTNNELGFDYLRDNMVVYRSQMVQRPLNYAIVDEVDSILIDEARTPLIISGQAEKSTALYTRADNFVKRLKEDEDYKIDIQSKTIGLTEAGIEKAEQTFGLDNLYDIENTALTHHLDQALRANYIMLLDIDYVVQDNKVLIVDQFTGRIMDGRRYSDGLHQAIEAKEGVEIEDETKTMATITFQNYFRMYKKLAGMTGTAKTEEEEFREIYNIQVIQIPTNRPIIRDDRPDLLYPTLESKFNAVVEDIKERYHKGQPVLVGTVAVETSELLSDKLNAAKIPHEVLNAKNHFKEAEIIMNAGQKGAVTIATNMAGRGTDIKLGLGVLELGGLAVIGTERHESRRIDNQLRGRAGRQGDPGVSQFYLSLEDDLMKRFGSERIKTFLERMNVQEEDAVIQSKMFTRQVESAQKRVEGNNYDTRKNVLQYDDVMREQREVIYAQRQEVIMEENDLSDVLMGMVKRTIGRVVDSHTQLEKEEWNLDGIVDFAASTLVHEDTISKKDLENKSAEEIKDYLVARAQEVFEEKSQQLNGQEQLLEFEKVVILRVVDTKWTDHIDAMDQLRQSVGLRAYGQNNPLVEYQTEGYSMYNNMVGSIEYEVTRLFMKSEIRQNVQREQVAQGQAEHPETEQDAAAQSNTSAKRQPVRVDKKVGRNDLCPCGSGKKFKNCHGRNA
>NZ_CP046113.1|WP_002357293.1|1472121_1472673_-|ribosome-associated-translation-inhibitor-RaiA
MFRYNVRGENIEVTEAIRDYVEKKVGKLERYFSDSPEATVHVNLKVYTEKTAKVEVTIPLPYLVLRAEETSPDLYASIDLVVDKLERQIRKFKTKINRKSRETGRNNTKAAVFLVGEETEETPSELDIVRTKRLSLKPMDSEEAVLQMNMLGHNFFIFEDAETNGTSIVYRRKDGKYGLIETD
>NZ_CP046113.1|WP_002379511.1|1472811_1473498_-|ComF-family-protein
MDCKNCASPIRLEITLKMLLRFKKWARPSLCQHCQVKFQKLPMTGTCFGCSRVSQEHYCFDCQRWQLLYPEYSFHNTALFHYDEGMQEWMERYKFQGDYRLRTCFNEEINFYFRQQSVDYIIPIPLSEKRMQKRGFNQVIGLLEAADVPYSPFLIRKEENVPQSKKTRKERMRLQQPFAIQKENQKKLKNCSVILVDDIYTTGRTLFHAAAVINDCYPKSLNTFTLAR

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Crispr_ID: NZ_CP046113_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046113_2

1677935-1678168

Orphan

II-A,II-B

Consensus_repeat	Method
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	CRISPRCasFinder
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	CRT
TGTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	PILER-CR

3 spacers

The CRISPR arrays of NZ_CP046113_2

>merge|NZ_CP046113|2|1677935-1678168|CRISPRCasFinder,CRT,PILER-CR
GTGATAGTTTGTTTTTTAACAACATGGCTCTAAAACTCATCATAGTATCGTAAAACTCTTTCTGGTGTTTTGGTACCATTCTAAACAACATGACTCTAAAACTTATTGCTTCACCTATTGGAATTGTAATTGGTTTTGGTACCATTCTAAACAACATGACTCTAAAACGAAAGGTGTCCGAACAGTGTCCGCAAGGCTGTTTTGGTACCATTCTAAACAACATGACTCTAAAAC

>NZ_CP046113|2|2|1677935-1678168|CRISPRCasFinder
GTGATAGTTTGTTTTTTAACAACATGGCTCTAAAAC	TCATCATAGTATCGTAAAACTCTTTCTGGT
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	TTATTGCTTCACCTATTGGAATTGTAATTG
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	GAAAGGTGTCCGAACAGTGTCCGCAAGGCT
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC

>NZ_CP046113|2|2|1677935-1678168|CRT
GTGATAGTTTGTTTTTTAACAACATGGCTCTAAAAC	TCATCATAGTATCGTAAAACTCTTTCTGGT
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	TTATTGCTTCACCTATTGGAATTGTAATTG
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	GAAAGGTGTCCGAACAGTGTCCGCAAGGCT
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC

>NZ_CP046113|2|2|1678000-1678168|PILER-CR
TGTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	TTATTGCTTCACCTATTGGAATTGTAATT
GGTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	GAAAGGTGTCCGAACAGTGTCCGCAAGGC
TGTTTTGGTACCATTCTAAACAACATGACTCTAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046113.1\|WP_002356965.1\|1681948_1682518_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379115
NZ_CP046113.1\|WP_002356959.1\|1685951_1686296_-\|DUF1831-domain-containing-protein	unknown	unknown	gnl\|CDD\|370163
NZ_CP046113.1\|WP_002379587.1\|1687665_1688640_-\|ribose-phosphate-diphosphokinase	unknown	unknown	gnl\|CDD\|235039
NZ_CP046113.1\|WP_002356976.1\|1675099_1676113_-\|cytochrome-d-ubiquinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|376764
NZ_CP046113.1\|WP_002374511.1\|1683182_1684421_+\|multidrug-efflux-MFS-transporter	unknown	unknown	gnl\|CDD\|340949
NZ_CP046113.1\|WP_010820099.1\|1665534_1667958_-\|DNA-translocase-FtsK	unknown	unknown	gnl\|CDD\|224588
NZ_CP046113.1\|WP_002360007.1\|1686363_1687509_-\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NZ_CP046113.1\|WP_002362075.1\|1684601_1685726_-\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NZ_CP046113.1\|WP_002364369.1\|1673361_1675095_-\|thiol-reductant-ABC-exporter-subunit-CydD	unknown	unknown	gnl\|CDD\|274323
NZ_CP046113.1\|WP_002360016.1\|1669511_1670417_-\|prenyltransferase	unknown	unknown	gnl\|CDD\|235695
NZ_CP046113.1\|WP_002379580.1\|1668271_1669483_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NZ_CP046113.1\|WP_002402469.1\|1679273_1681523_-\|DNA-topoisomerase-III	unknown	unknown	gnl\|CDD\|236078
NZ_CP046113.1\|WP_002362073.1\|1682650_1683166_+\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	unknown	unknown	gnl\|CDD\|176643
NZ_CP046113.1\|WP_002381711.1\|1663835_1664585_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224059
NZ_CP046113.1\|WP_002356974.1\|1676109_1677528_-\|cytochrome-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|376587
NZ_CP046113.1\|WP_174776027.1\|1678325_1679189_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP046113.1\|WP_002356966.1\|1681485_1681851_-\|DUF1033-family-protein	unknown	unknown	gnl\|CDD\|336361
NZ_CP046113.1\|WP_002364244.1\|1664702_1665404_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NZ_CP046113.1\|WP_002360015.1\|1670538_1671519_+\|polyprenyl-synthetase-family-protein	unknown	unknown	gnl\|CDD\|223220
NZ_CP046113.1\|WP_002379581.1\|1671598_1673365_-\|thiol-reductant-ABC-exporter-subunit-CydC	unknown	unknown	gnl\|CDD\|227320

Protein	Function_ID	Function_description	E-value
NZ_CP046113.1\|WP_002356965.1\|1681948_1682518_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379115	pfam13305, WHG, WHG domain. This presumed domain is around 80 amino acids in length. It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. The domain is named WHG after three conserved residues near the C-terminus of the domain.	2.91104e-15
NZ_CP046113.1\|WP_002356959.1\|1685951_1686296_-\|DUF1831-domain-containing-protein	gnl\|CDD\|370163	pfam08866, DUF1831, Putative amino acid metabolism. Solution of the structure of the Lactobacillus plantarum protein from this family has indicated a potential new fold with remote similarities to TBP-like (TATA-binding protein) structures. This similarity, in combination with genomic context analysis, leads us to propose an involvement in amino-acid metabolism. The potentially novel fold is an alpha + beta fold comprising two beta sheets packed against a single helix. The enzyme is present in the cytosol.	1.33245e-53
NZ_CP046113.1\|WP_002379587.1\|1687665_1688640_-\|ribose-phosphate-diphosphokinase	gnl\|CDD\|235039	PRK02458, PRK02458, ribose-phosphate pyrophosphokinase; Provisional.	0
NZ_CP046113.1\|WP_002356976.1\|1675099_1676113_-\|cytochrome-d-ubiquinol-oxidase-subunit-II	gnl\|CDD\|376764	pfam02322, Cyt_bd_oxida_II, Cytochrome bd terminal oxidase subunit II. This family consists of cytochrome bd type terminal oxidases that catalyze quinol-dependent, Na+-independent oxygen uptake. Members of this family are integral membrane proteins and contain a protohaem IX centre B558. One member of the family, Klebsiella pneumoniae CydB, is implicated in having an important role in micro-aerobic nitrogen fixation in the enteric bacterium Klebsiella pneumoniae. The family forms an integral functional unit with subunit I, family Bac_Ubq_Cox, pfam01654.	9.60464e-103
NZ_CP046113.1\|WP_002374511.1\|1683182_1684421_+\|multidrug-efflux-MFS-transporter	gnl\|CDD\|340949	cd17391, MFS_MdtG_MDR_like, Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.68462e-173
NZ_CP046113.1\|WP_010820099.1\|1665534_1667958_-\|DNA-translocase-FtsK	gnl\|CDD\|224588	COG1674, FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning].	6.32186e-175
NZ_CP046113.1\|WP_002360007.1\|1686363_1687509_-\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	5.37018e-179
NZ_CP046113.1\|WP_002362075.1\|1684601_1685726_-\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NZ_CP046113.1\|WP_002364369.1\|1673361_1675095_-\|thiol-reductant-ABC-exporter-subunit-CydD	gnl\|CDD\|274323	TIGR02857, transport_ATP-binding_protein, thiol reductant ABC exporter, CydD subunit. The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex. Unfortunately, the gene symbol nomenclature adopted based on this operon in B. subtilis assigns cydC to the third gene in the operon where this gene is actually homologous to the E. coli cydD gene. We have chosen to name all homologs in this family in accordance with the precedence of publication of the E. coli name, CydD.	0
NZ_CP046113.1\|WP_002360016.1\|1669511_1670417_-\|prenyltransferase	gnl\|CDD\|235695	PRK06080, PRK06080, 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated.	8.82053e-105
NZ_CP046113.1\|WP_002379580.1\|1668271_1669483_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	4.15123e-121
NZ_CP046113.1\|WP_002402469.1\|1679273_1681523_-\|DNA-topoisomerase-III	gnl\|CDD\|236078	PRK07726, PRK07726, DNA topoisomerase 3.	0
NZ_CP046113.1\|WP_002362073.1\|1682650_1683166_+\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	gnl\|CDD\|176643	cd00865, PEBP_bact_arch, PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea. PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in bacterial and archaea. Members here include Escherichia coli YBHB and YBCL which are thought to regulate protein phosphorylation as well as Sulfolobus solfataricus SsCEI which inhibits serine proteases alpha-chymotrypsin and elastase. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer). In a few of the bacterial members present here the dimerization interface is proposed to form the ligand binding site, unlike in other PEBP members.	1.1162e-31
NZ_CP046113.1\|WP_002381711.1\|1663835_1664585_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	2.63593e-110
NZ_CP046113.1\|WP_002356974.1\|1676109_1677528_-\|cytochrome-ubiquinol-oxidase-subunit-I	gnl\|CDD\|376587	pfam01654, Cyt_bd_oxida_I, Cytochrome bd terminal oxidase subunit I. This family are the alternative oxidases found in many bacteria which oxidize ubiquinol and reduce oxygen as part of the electron transport chain. This family is the subunit I of the oxidase E. coli has two copies of the oxidase, bo and bd', both of which are represented here In some nitrogen fixing bacteria, e.g. Klebsiella pneumoniae this oxidase is responsible for removing oxygen in microaerobic conditions, making the oxidase required for nitrogen fixation. This subunit binds a single b-haem, through ligands at His186 and Met393 (using SW:P11026 numbering). In addition His19 is a ligand for the haem b found in subunit II.	0
NZ_CP046113.1\|WP_174776027.1\|1678325_1679189_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	3.24758e-27
NZ_CP046113.1\|WP_002356966.1\|1681485_1681851_-\|DUF1033-family-protein	gnl\|CDD\|336361	pfam06279, DUF1033, Protein of unknown function (DUF1033). This family consists of several hypothetical bacterial proteins. Many of the sequences in this family are annotated as putative DNA binding proteins but the function of this family is unknown.	4.62165e-64
NZ_CP046113.1\|WP_002364244.1\|1664702_1665404_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	1.52313e-37
NZ_CP046113.1\|WP_002360015.1\|1670538_1671519_+\|polyprenyl-synthetase-family-protein	gnl\|CDD\|223220	COG0142, IspA, Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism].	2.52576e-80
NZ_CP046113.1\|WP_002379581.1\|1671598_1673365_-\|thiol-reductant-ABC-exporter-subunit-CydC	gnl\|CDD\|227320	COG4987, CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones].	0

>NZ_CP046113.1|WP_002356974.1|1676109_1677528_-|cytochrome-ubiquinol-oxidase-subunit-I
MFDIVTLARIQFAMTTVFHFFFVPFSIGLALVVAIMETMYVVKKEERYRKMAKFWGNIFLLSFAVGVVTGIIQEFQFGMNWSDYSRFVGDIFGAPLAVEALLAFFLESTFLGLWIFTWDKMNPKVHVTFIWLVVFGSMMSAFWILVANSFMQHPVGYVINNGRAEMVDFVAVISNPKVWYEFSHVIMGAFTLGGMAVAGMAAFQLLKKRDISFHKASMRIGLWVTLFGSIGVLLAGDLQMKALIEGQPMKFAAMEGAYEDSDDPAAWTLIAWADEREHKQVFGIDIPYMLSILSYNKLSGSVDGMDTVNKRLVEKYGDDKNYYPPVNTLFWSFRIMAGFGALMLLVAALGLFFTRKKKPSLYEKKWMLWIVALCTFAPFLANTTGWLVTELGRYPWTVYGLFTIEQSVSPNVSVASLITSNVIYFLLFAGLGSVMVYLVILELRKGPDYEAKKLAKENEPALDPFDKGVFGE
>NZ_CP046113.1|WP_002356976.1|1675099_1676113_-|cytochrome-d-ubiquinol-oxidase-subunit-II
MSTLQLLWFVLIGVLFSGFFFLEGFDFGVGMAVQTLAHNDDEKDQVVATIGPVWDGNEVWLLTAGGAMFASFPYWYASLFSGYYLILFTILFGLIIRGVSFEFRHNMPEGKRRRMWNWTLSIGSFLVPFFFGILFISLVQGMPLDANGNMHAQFTDYFNLFSIVGGVALTLLCYLHGMNYIALKTEGPIRERARNYAEILYGVLYVGLVVFAVLMYFKTDFYEKNFAVTLILTLAIVVLTVIANVGVFKRKEMLAFLASGLTLVVLVALLFSGLFPRVMIGSEGFDLLIKDATSTPYTLKIMTWISLSILPFVLAYTAWSYYIFRKRISQTAVPEGY
>NZ_CP046113.1|WP_002364369.1|1673361_1675095_-|thiol-reductant-ABC-exporter-subunit-CydD
MIDKDILQMPKIKKILVLLAGFSFLQAVFIIGQAFFLSKAIVGLWSGGHLNQQLQSILLFFIFYLGRHVITYFRERMLDTFSYERSKELREQLLTKIFRLGPNVVQKNGTGNMVTMALEGISQTENYLQLILTKMMNMMIIPWIILAFVFTQDIRSGVTLLIVFPIIIIFMIVLGYAAQSKADKQYAAFQMLSNHFIDSLRGIDTLKLFGLSKKYAGSIYHTSERFRKATMSTLKIAILSTFALDFFTTLSVAVVAVFLGLSLLNGTILLFPALVTLILAPEFFLPIRDFSSDYHATLDGKNSFQAIQAVLALPEAEQTDVLTLDDWHQESQLSVTALNFSYEDATQEAIQSLQFSVDGRKKIGIIGASGSGKSTLINLLSGFLLPTEETSQLAINGQTIPHFLQKDWQKQILYIPQAPYIFQDTLANNIRFYTPEATDEAIQQAIQLVGLDELVKDLPEGIHTLIGESGRMLSGGQAQRVALARAFVDQKRHVLLFDEPTAHLDIETEVEMKERMLPLMNNHLVFFATHRLHWMEEMDYILVMEKGQLVEQGTLAELIEKDGYYVQLMKQMRGGRQ
>NZ_CP046113.1|WP_002379581.1|1671598_1673365_-|thiol-reductant-ABC-exporter-subunit-CydC
MMEKQPTTKDVWKNDQWVRPFLKRYKKTLYFALLLGFLTFFSAGALMFTSGYLISRAASLPENILLIYIPIVLTRAFGIGRPVFRYVERLTSHNWVLKMTSDLRLKLYNVLEKDAIFFKTKYRTGDILGLLSEDINHIQNLYLRTIFPTVIAWILYIFLVIALGFFSWWFALCMLLMLGVVVFLLPLVSVLVNGARQEKHKYAKNELYQTLTDNILGVSDWVFSQRGSEFVARYETDEANVRALDEKMKQFNRGRDFVLQLLFGVIAIAVLAWTSVRFPGNHGGAANWIGAFVLTVFPLIDAFAPLPAAAQETTIYKDSIRRFNELPEGEDDSTEAPVQPNGTSLSIEHLSFAYENQAKKVLNDLSLTIPEKQKLAILGRSGSGKSTLASLIRGDLRPTSGEILLGNIPTEAFGETMTEYIGVMHQAPYLFRTTILNNIRIGREEASEAEVWAVLEKVGLKEMVAQLPEGLQTMVDEAGLRFSGGERHRLALARILLQDTPIVLLDEPTTGLDPITEQQLLETFFEALKDKTVIWITHHLQGVTLMDQVIFIEDGQLEMSGTPEELLATNAHYQKLYRIDRGISSFEE
>NZ_CP046113.1|WP_002360015.1|1670538_1671519_+|polyprenyl-synthetase-family-protein
MNTFWKSFPDVERSLTETCELIEQTLHTRNEDIEEALVTLARSGGKLLRPAFFFLFAQLGDEEKQEKQQLLKIAASLEILHMATLIHDDIIDDSPLRRGAVTIQSQYGKDVAVYTGDLLFTEFFTLIADAMNGSEFMKINAQGMKRLLLGELDQMSHRFDRRMSIPAYLRSVNGKTAELFSLSCLEGAYFGHSSKEVQRLAKRIGRHIGIAFQVYDDILDYTADTETLKKPALEDLSQGVYTLPLLFAYQAAPDVFSPYLDKGRAITLEEAAEVAALVNDYHGVTEAQAFAKKVTNKAITDIQQLPDGTAKETLLSLTELLLHRSF
>NZ_CP046113.1|WP_002360016.1|1669511_1670417_-|prenyltransferase
MNREIFFELVELKAKTASVLPFLLGICFSWYQYGRLHVGYVLIFFIAMFIFNMAVDILDNYNDYHHATEVHDYKEKTNIIGRENLSLPLIRKMIFWMILVSALMGIGLSFIVGWPLLIMGLYCYLIGIFYSSGPKPLSSLPLGEVFSGFTMGFMITLICVYINTFEVFNWSAANLWGIFLVALPNTCYIANLMLANNICDLEEDENNKRYTLVHYLGKASSLKLFVGLNTIAMLAILLAVGLGLTPPTMLLMLLTLPFVRKQTQALLKEQVKSKTFVCAVKILAVGATAQVLFFAIGLWWL
>NZ_CP046113.1|WP_002379580.1|1668271_1669483_-|NAD(P)/FAD-dependent-oxidoreductase
MNKKHVVILGAGYAGLKTLRELQKGAKDVEITLVDRNNYHYEATDLHEVAAGTQPAEKITYNIMDVVDEKMTTFIQGTVKTIDAATQTVALEDGQTINYDYLVVSLGFESESFGIPGVQEHALQMVDVKTALNVYEHIQEQMRQYKATQNEEFLKIVVCGAGFTGIELLGSLFENKPKFAEIAGVSADQIQIYCVEAVTRLLPMFNEKLANYGVQLLKDSAIHLLLGKPIKEIKPGAVVYQDNEAGDLAELSAKTIIWTTGVSGSHVVGDSGFEARRGRVMVQPDLTDANHSNVYIIGDCSAVMDTETNRPYPTTAQIALKMGAHAAKNIQAQLKGEATKPFSFKSQGSVCSVGNTRALGIVGKTDIKGYPASFMKKIIMNKALFETGGTKEMMAKGRFDLYH
>NZ_CP046113.1|WP_010820099.1|1665534_1667958_-|DNA-translocase-FtsK
MAQKRATNKKKSTTKKKTKKQQQQQERLNYMFLGLIFILFGVFGLFRLGFLGTLLANCLRLVVGNTFPFAAILLILYGLLVMIYGKDFPLKRGRPIFGAVLIYISVLLFFHAFMFRNVSGSQPDILGNTWEFLQSDLKANQVTQNVGGGMIGALLYQGTYFLVAQFGSYLIATLLLLAGIFLMSMWDFQQIVDHFQSIQDRLSHVSAKSQERQEEKEAKRAAKKEAKAAERQAKIEAAAQQKLQERERMEQAAAERLTKTPVETHQPMVEEPAAPTPVQIDSFQQQNQAMPVPPIAATKPQREQEEEAADEAGVLEFEISEEAEDRDYQLPPTDLLDTIQATDQSGEYEKIEKNIGVLEQTFKSFGVDAKVVKASLGPSVTKFEVQPAVGVKVSKIVNLTDDIALALAAKDVRMEAPIPGKSLIGIEVPNSAISTVSFRDIVEAQPSHPDKLLEVPLGRDISGMVQTADLSKMPHLLIAGSTGSGKSVAINGIITGILMQAKPHEVKLMMIDPKMVELNVYNGIPHLLTPVVTNPRKAAQALQKVVQEMEFRYEKFAATGVRNITGYNQLIQQKNAEDGENRPILPFIVVIVDELADLMMVASNEVEDAIIRLAQMARAAGIHMILATQRPSVDVITGIIKANVPSRMAFAVSSGTDSRTIIDTNGAEKLLGRGDMLFLPMGENKPIRIQGAFISDQEVERVVAFVTDQQEAEYQESMMPTDEPTTSGGGEAPQDELFEEAKNLVVEMQTASISLLQRRFRIGYNRAARLVDELEAHGVIGPSEGSKPRKVFLQAESEEAVPETPEQ
>NZ_CP046113.1|WP_002364244.1|1664702_1665404_-|GntR-family-transcriptional-regulator
MRRKSVLYLEVADQIKEDILSGKYPVGTFLPTETELEELFNVSKITIRRAIEMLATEEFVEKKSGRGTTVLSNRPYNKLSKAGTFTEFLNESGQKVTKKVLQVENLTLSKEMPAYQFLGEEVVHLSRLYLIDEQPYIYFNYYLPAAMKDVSLTEYKEESLYRLMDRHAIEIYKFEDRFEVATLTEAEQKMLQTTETTGLKRIRRSLSPTGRCVEYSEAIYNTKIHPYVIEYEA
>NZ_CP046113.1|WP_002381711.1|1663835_1664585_-|ABC-transporter-ATP-binding-protein
MLEVQNLKKVYGNEIKYEALKGINLTVQDGEFIGIMGPSGSGKSTLLNLLATIDSPTDGEILLNGKNPNNLNQEQIAKFRRTELGFVFQSFNLMPTLTVEENIILPLTLDGEKVSVMKRQLAELSERLGINHLLKKRIAEISGGQAQRVAVARAMIHHPQLLLADEPTGNLDTKSSKDVMGLLQQLNEEEAATILMVTHDPLAASYCKRIVFIKDGELIDEIVQNGNQKEFYDLIMVKLAEIEGVDNEF
>NZ_CP046113.1|WP_174776027.1|1678325_1679189_-|AraC-family-transcriptional-regulator
MLANLNQAMDYIEEHLTEEVSFDELAKKTGISVYHFKRTFSFVAGMSLAEYIKKRRLAEANLALLAGEKVTDVAFKYGYQSIEGFSRAFRDWTGQAPSEVMKTQIQKTFPKFSFYIDIKGGQSMDVKLIEKPAFQIVGVSQKVPLQYQGENQAIMELAQRITPQQRAEMHTFDDVYPHQVVNASFDFQEGRTTEGGEMTHMISFVTSQENTYEDLEQLSVPAHTWAVFPNEGPFPQTLQETWARIFSEWLPSSGYQVVAAPEISFTQYQGPAEAKYSEIWLAVTATK
>NZ_CP046113.1|WP_002402469.1|1679273_1681523_-|DNA-topoisomerase-III
MAKQNSANGKLFETHEFKEKPQGIFFKLFFYSRNLEKIEPIFGIIRKDSTQKGAKLVVAKQLIIAEKPSVAKDLSRVLGANQKNKNYYEGPNVIVTWALGHLLGLKMPEDLNKEWQTWQMETLPMIPKNLGIKPLPKTGHQLKAIKQLANRKDVSEAVIATDAGREGELVARWILEYVRFNKPVKRLWISSQTDKAIKDGFKKIRPAKDYDNLYYSALARAKADWLVGLNVTRALTVKYQDNLSAGRVQTPTLAMVRQQEKTIEQFKPQTYFTISLTVESEKAKMTQKNPYALKERQEAEQLVKELSKQKGLVTDIQEKVKTENAPLPYDLTEIQREANQRFQFSAKKTLSLVQSLYETHKIVSYPRTDSKYLTTDMKGTMKERLQAIADFSPEVKGYLKNGAVVKQQKVFQNAKVTDHHGLIPTEQRPRYEKLSNDEQKIYQMIVQRFLGLFAEPNQTKQTKVTVAFGKETFVFHQNKVVVAGWKTTAEQPLSTVQWQKGMTVAPNFTINKELTSPPKPLTEGTLLGKMEKHSLGTPATRAEIIEKLIKSELMERTNSGLSVSAKGKQLLDLVNPSLVTPELTEKWEKSLEAIASGQQKSQLFLKDIEEDTKKLVREIKQSEKKYQDFSITQKKCPDCGSNLREKNTKDGKIYVCTNQECSYRRRKDPKVSNHRCPQCHKKMVIIEGKNGRSFKCKFCSITEKIPDKKERKQKMTKHEERRLMKKYSQPDEPEESALAQALKAAMNQE
>NZ_CP046113.1|WP_002356966.1|1681485_1681851_-|DUF1033-family-protein
MYQVITMYGDNEPWWFFDDWQEDIVQEKTFDNLTDAETYYVEVWQKLSQNYTYVNTKPNYLTAFWNDGEERWCEECDEDLQQYFGLALLENHHAVTFENKAEFTTISNHFGKTKFCKRKVI
>NZ_CP046113.1|WP_002356965.1|1681948_1682518_-|TetR/AcrR-family-transcriptional-regulator
MAKKRNLTKAKILESARNLAEELGVQQLTFQNLAVDLGIKYPSLYNHFKNIAEVKNALVDLLIQELNDALRRALVGKSGAEAIRIYAETYQQFAFENSAVYELLISVPKTQNQQLIEGIHETNQIILQLLAFYPFNNEERLHKSRELRSLIHGYITLRFLGYFQREEATPEESYRRMIEDFIASLEVAG
>NZ_CP046113.1|WP_002362073.1|1682650_1683166_+|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein
MHITNRSHLADRYGKRTSAEFLLHERPILSFPISLAAIPKEARYLSWELIDYDTIPLIGFPFIHWLAANVPVTNEIPEDFSRTALKPTIQGKNSLASPLGKQMIPALATETLPELTERYLGLSPRSGVHTYTLYVYATKNPLNLKEGFFANELHQALNDQRLAKAKFEFLY
>NZ_CP046113.1|WP_002374511.1|1683182_1684421_+|multidrug-efflux-MFS-transporter
MYELIKSKIFRPRQPWEKNLLVLWFGTFMAGIGFSLVMPFMPLYINTLGTFTHQQLNFWSGITFSSTFLVTTIVSPWWGRLADRKGRKLMLLRASLGMAIVISLMGAVTSVYQLIGLRLLQGVFSGYISNATALVATGTPKEKSGQVLGTLATGSVTGTLLGPLLGGVTASIFGYRPTFFITGTILLLVFVLSLVFVHEEFVPIEKNQAASGKQILKKLEHPHVILGMFITTLIIQASNNSISPIISLYIQQLLGGHGNVTLISGVIASIPGIATLIAAPRFGRLGDRIGSERILTIGLILAIFVYLPMAFVQNVWQLAMLRFLVGISDACLLPAVQTLITRYSPSDAAGRIFSYNQSFQATGNVIGPMIGSSVSAAFGYRGVFISTSCLVLLNLLWVRRSTAELKKEKNDA
>NZ_CP046113.1|WP_002362075.1|1684601_1685726_-|tRNA-2-thiouridine(34)-synthase-MnmA
MADNSKTRVVVGMSGGVDSSVTALLLKEQGYDVIGIFMKNWDDTDENGVCTATEDYKDVAKVADQIGIPYYSVNFEKEYWDRVFEYFLAEYRLGRTPNPDVMCNKEIKFKAFLDYAMQLGADYVATGHYAQVETDENGVVHMLRGIDNNKDQTYFLSQLSQAQLAKTMFPLGGMEKSEVRAIAERAGLATAKKKDSTGVCFIGEKNFKEFLSNYLPAKKGNMVTEDGEIKGQHDGLMYYTIGQRQGLGIGGGGKTQEPWFVIGKDLTTNTLYVGQGFHHEKLYATHLEASEVHFTVDTPMPKEFDCTAKFRYRQADIPVHVSLSEDGTKATVTFKEPARAVTPGQAVVFYDGMECLGGGLIDRAYQDEKELQYV
>NZ_CP046113.1|WP_002356959.1|1685951_1686296_-|DUF1831-domain-containing-protein
MAFTTTAAVEGSTVFYKVHPSAKRYTLKDNGFTETKSGNFQLIRSLDPTPQRNEGFKLKITITADLKELKMSITTANGLKPMNIFKNEQHEMSKEKYFFLMDGLISRGVLEKVE
>NZ_CP046113.1|WP_002360007.1|1686363_1687509_-|cysteine-desulfurase
MEPIYLDHAATTPLHPTVIQAMTENMQTTFGNPSSIHQFGRKAHGLLEEVRQTIAESLQAKPHEIIFNSGGTEGDNTAILAVAFSRQKEGKHIITTAIEHPAVLRTMEYLETLGFEVTYLPVNENGQISMDQFKKSLREETILVSMMYGNNEIGNRLPIAEVGAILKNHSAIFHTDAVQAYGSEVILPHELGIDLLSISAHKINGPKGVGFLFKSDAIQLPPLLHGGEQEEKRRAGTENLAGIIGMGTAVSLLTSAEKQARKTAYQSFQTIILKALEEANIDFSINGEPTNRLAHVLNLHLKGIPSDLLLMHLDLRGIAISTGSACTAGTVDPSHVLTAMYGENSSAIKESIRISFGYGNTPEEIATFSEVLVAVIQQLKK
>NZ_CP046113.1|WP_002379587.1|1687665_1688640_-|ribose-phosphate-diphosphokinase
MTENYQDDTLRIFSLNANRPLAEKIAASVGTELGKSTVRQFSDGEIQINIEESIRGDHVYIIQATNAPVNDHLMELLILIDALKRASAKTVNVILPYYGYARQDRTAKPREPITAKLVANMLVEAGATRLLTLDLHTVQVQGFFDIPVDNLFTMPLFAHYYRQQALVGEEIVIVSPKNSGVQRARSLSEYLDATLAIVDHEEIDGVRQEGYVIGNVAGKKCILVDDILNTGQTLATAAEVLMKNGAQEVYACASHGLLSEGAKATLENAPIKEISITDSVYTTADRQPATLNIISCAELMGEALLRIHENKPMSPLFRLEPKGE

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Crispr_ID: NZ_CP046113_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP046113_3

2500001-2500074

Orphan

Consensus_repeat	Method
ATAGTTGGCGAGCAACAGAAAAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP046113_3

>merge|NZ_CP046113|3|2500001-2500074|CRISPRCasFinder
ATAGTTGGCGAGCAACAGAAAAACTCGATATAGAATTGGACGTAGAGCCAATAGTTGGTGAGCAACAGAAAAAC

>NZ_CP046113|3|3|2500001-2500074|CRISPRCasFinder
ATAGTTGGCGAGCAACAGAAAAAC	TCGATATAGAATTGGACGTAGAGCCA
ATAGTTGGTGAGCAACAGAAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP046113.1\|WP_025187370.1\|2494195_2494894_-\|WxL-domain-containing-protein	unknown	unknown	gnl\|CDD\|372694
NZ_CP046113.1\|WP_002378981.1\|2490118_2491423_-\|insulinase-family-protein	unknown	unknown	gnl\|CDD\|223685
NZ_CP046113.1\|WP_002378984.1\|2493382_2494099_-\|WxL-domain-containing-protein	unknown	unknown	gnl\|CDD\|372694
NZ_CP046113.1\|WP_002354863.1\|2510533_2512090_-\|ribonuclease-Y	unknown	unknown	gnl\|CDD\|237177
NZ_CP046113.1\|WP_002367457.1\|2499028_2499679_+\|beta-phosphoglucomutase	unknown	unknown	gnl\|CDD\|213672
NZ_CP046113.1\|WP_002378991.1\|2504375_2506508_-\|DNA-mismatch-repair-endonuclease-MutL	unknown	unknown	gnl\|CDD\|223400
NZ_CP046113.1\|WP_002359021.1\|2488703_2488916_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP046113.1\|WP_002378992.1\|2506539_2509116_-\|DNA-mismatch-repair-protein-MutS	unknown	unknown	gnl\|CDD\|235444
NZ_CP046113.1\|WP_002354871.1\|2503226_2503664_-\|peptide-methionine-(R)-S-oxide-reductase-MsrB	unknown	unknown	gnl\|CDD\|234692
NZ_CP046113.1\|WP_002381060.1\|2502080_2503052_-\|ribose-phosphate-diphosphokinase	unknown	unknown	gnl\|CDD\|234929
NZ_CP046113.1\|WP_002354869.1\|2503796_2504351_-\|septum-formation-protein-Maf	unknown	unknown	gnl\|CDD\|238310
NZ_CP046113.1\|WP_002359008.1\|2509116_2509503_-\|YlbF-family-regulator	unknown	unknown	gnl\|CDD\|226923
NZ_CP046113.1\|WP_016633960.1\|2496269_2499014_+\|glycoside-hydrolase-family-65-protein	unknown	unknown	gnl\|CDD\|224471
NZ_CP046113.1\|WP_002378983.1\|2491415_2492684_-\|insulinase-family-protein	unknown	unknown	gnl\|CDD\|223685
NZ_CP046113.1\|WP_002354864.1\|2509576_2510374_-\|TIGR00282-family-metallophosphoesterase	unknown	unknown	gnl\|CDD\|379099
NZ_CP046113.1\|WP_002385181.1\|2500140_2500734_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376232
NZ_CP046113.1\|WP_002359018.1\|2492892_2493342_+\|large-conductance-mechanosensitive-channel-protein-MscL	unknown	unknown	gnl\|CDD\|376605
NZ_CP046113.1\|WP_002385180.1\|2501495_2502029_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP046113.1\|WP_002354877.1\|2495294_2496008_-\|trehalose-operon-repressor	unknown	unknown	gnl\|CDD\|274116
NZ_CP046113.1\|WP_016633961.1\|2489084_2489951_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224343

Protein	Function_ID	Function_description	E-value
NZ_CP046113.1\|WP_025187370.1\|2494195_2494894_-\|WxL-domain-containing-protein	gnl\|CDD\|372694	pfam13731, WxL, WxL domain surface cell wall-binding. The WxL motif appears in two or three copies in these bacterial proteins and confers a cell surface localization function. It seems likely that this region is the cell wall-binding domain of gram-positive bacteria, and may interact with the peptidoglycan.	4.98763e-09
NZ_CP046113.1\|WP_002378981.1\|2490118_2491423_-\|insulinase-family-protein	gnl\|CDD\|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	1.62226e-84
NZ_CP046113.1\|WP_002378984.1\|2493382_2494099_-\|WxL-domain-containing-protein	gnl\|CDD\|372694	pfam13731, WxL, WxL domain surface cell wall-binding. The WxL motif appears in two or three copies in these bacterial proteins and confers a cell surface localization function. It seems likely that this region is the cell wall-binding domain of gram-positive bacteria, and may interact with the peptidoglycan.	4.48652e-24
NZ_CP046113.1\|WP_002354863.1\|2510533_2512090_-\|ribonuclease-Y	gnl\|CDD\|237177	PRK12704, PRK12704, phosphodiesterase; Provisional.	0
NZ_CP046113.1\|WP_002367457.1\|2499028_2499679_+\|beta-phosphoglucomutase	gnl\|CDD\|213672	TIGR01990, bPGM, beta-phosphoglucomutase. This model represents the beta-phosphoglucomutase enzyme which catalyzes the interconverison of beta-D-glucose-1-phosphate and beta-D-glucose-6-phosphate. The 6-phosphate is capable of non-enzymatic anomerization (alpha <-> beta) while the 1-phosphate is not. A separate enzyme is responsible for the isomerization of the alpha anomers. Beta-D-glucose-1-phosphate results from the phosphorylysis of maltose (2.4.1.8), trehalose (2.4.1.64) or trehalose-6-phosphate (2.4.1.216). Alternatively, these reactions can be run in the synthetic direction to create the disaccharides. All sequenced genomes which contain a member of this family also appear to contain at least one putative maltose or trehalose phosphorylase. Three species, Lactococcus, Enterococcus and Neisseria appear to contain a pair of paralogous beta-PGM's. Beta-phosphoglucomutase is a member of the haloacid dehalogenase superfamily of hydrolase enzymes. These enzymes are characterized by a series of three catalytic motifs positioned within an alpha-beta (Rossman) fold. beta-PGM contains an inserted alpha helical domain in between the first and second conserved motifs and thus is a member of subfamily IA of the superfamily. The third catalytic motif comes in three variants, the third of which, containing a conserved DD or ED, is the only one found here as well as in several other related enzymes (TIGR01509). The enzyme from L. lactis has been extensively characterized including a remarkable crystal structure which traps the pentacoordinate transition state. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	1.52041e-106
NZ_CP046113.1\|WP_002378991.1\|2504375_2506508_-\|DNA-mismatch-repair-endonuclease-MutL	gnl\|CDD\|223400	COG0323, MutL, DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair].	0
NZ_CP046113.1\|WP_002354871.1\|2503226_2503664_-\|peptide-methionine-(R)-S-oxide-reductase-MsrB	gnl\|CDD\|234692	PRK00222, PRK00222, peptide-methionine (R)-S-oxide reductase MsrB.	2.48715e-93
NZ_CP046113.1\|WP_002378992.1\|2506539_2509116_-\|DNA-mismatch-repair-protein-MutS	gnl\|CDD\|235444	PRK05399, PRK05399, DNA mismatch repair protein MutS; Provisional.	0
NZ_CP046113.1\|WP_016633961.1\|2489084_2489951_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224343	COG1426, COG1426, Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown].	1.30351e-35
NZ_CP046113.1\|WP_002354869.1\|2503796_2504351_-\|septum-formation-protein-Maf	gnl\|CDD\|238310	cd00555, Maf, Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or nucleic acid-binding protein with structural similarity to the hypoxanthine/xanthine NTP pyrophosphatase Ham1 from Methanococcus jannaschii, RNase H from Escherichia coli, and some other nucleotide or RNA-binding proteins.	1.6551e-85
NZ_CP046113.1\|WP_016633960.1\|2496269_2499014_+\|glycoside-hydrolase-family-65-protein	gnl\|CDD\|224471	COG1554, ATH1, Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism].	1.10007e-171
NZ_CP046113.1\|WP_002378983.1\|2491415_2492684_-\|insulinase-family-protein	gnl\|CDD\|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	2.04695e-51
NZ_CP046113.1\|WP_002359008.1\|2509116_2509503_-\|YlbF-family-regulator	gnl\|CDD\|226923	COG4550, COG4550, Predicted membrane protein [Function unknown].	2.38925e-14
NZ_CP046113.1\|WP_002354864.1\|2509576_2510374_-\|TIGR00282-family-metallophosphoesterase	gnl\|CDD\|379099	pfam13277, YmdB, YmdB-like protein. This family of putative phosphoesterases contains the B. subtilis protein YmdB.	2.68643e-155
NZ_CP046113.1\|WP_002385181.1\|2500140_2500734_+\|hypothetical-protein	gnl\|CDD\|376232	pfam18813, PBECR4, phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease4. A predicted endoRNase of the Barnase-EndoU-ColicinE5/D-RelE like nuclease fold found in polyvalent proteins of phages and conjugative elements. The predicted active site contains a conserved histidine residue.	2.0486e-23
NZ_CP046113.1\|WP_002359018.1\|2492892_2493342_+\|large-conductance-mechanosensitive-channel-protein-MscL	gnl\|CDD\|376605	pfam01741, MscL, Large-conductance mechanosensitive channel, MscL.	2.66655e-49
NZ_CP046113.1\|WP_002381060.1\|2502080_2503052_-\|ribose-phosphate-diphosphokinase	gnl\|CDD\|234929	PRK01259, PRK01259, ribose-phosphate diphosphokinase.	0
NZ_CP046113.1\|WP_002354877.1\|2495294_2496008_-\|trehalose-operon-repressor	gnl\|CDD\|274116	TIGR02404, Trehalose_operon_transcriptional_repressor, trehalose operon repressor, B. subtilis-type. This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions].	6.92052e-137
NZ_CP046113.1\|WP_002385180.1\|2501495_2502029_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	1.58164e-07

>NZ_CP046113.1|WP_002367457.1|2499028_2499679_+|beta-phosphoglucomutase
MTIGFIFDLDGVITDTAKFHYQAWKALADSLGIPIDETFNETLKGISRMDSLDRILAHGHRENAFTPAEKEALAQQKNDHYVQLLEHLTTEDVLPGVVPLLQQAQARHIPCAVASASKNAPLILEKLGVRAYFATIVDPDSLSKGKPDPEIFLAAADSIGVLPQNAIGFEDAQSGIDGLKAAGIYAVGLSASQPLIGADMQVSEMTELSVDALLNR
>NZ_CP046113.1|WP_016633960.1|2496269_2499014_+|glycoside-hydrolase-family-65-protein
MSIQVHKEAPNMTILELTFATNQLTTTFFNHKLEPLHQKTFPFEALTIEETVPELCQLILAEAAPILGGIVADFPADFFSPEETLALVPQAVIQAFAEQLNTPLLTAAEQAAAPNLLEAFEEKRQYLAWHLDYYGYVPGKNEYAVESLLTVGNGFLGLRGTTPEMTISDDHYPATYIAGLYNTAASEVAGQVVENEDFVNAPDNQHIALKIGDATDWLTISPDTLQQLHRQLNLKTGLFVAEMILKDADNQQIKLTTKKIANMAQPNDYHLQYTFEPLNFSAPITLKTVTDGSVYNYNVARYRNLTAKHFQVTALSAQENKTVIEVCTNQSNLSVRETALITGDFFEKEAIMIQEEAEKIAQVVTVMAHQGTRYTLEKQVFVQASHAEQSWQVPFTPKDSFAAAAQESARAWQTLWQQANITVTGDLMSQKLLRIHSYHLLASASPFSNQAQALDVSITARGLHGEAYRGHIFWDEIFILPFYIQHYPDTARQLLLYRYHRLEKAKENAAASQYRGAMYPWQSGRDGRETTQKLHLNPLNGHWGEDHSILQRHVSLAIAYNAWLYWHSTQDHEFMKQYGGEMLLEIAQFWNSAATLDDATGRFFIDKVMGPDEFHEGYPDQAESGLKNNAYTNLMVVWLFEELTNILALFSEEEQAQLFAKTQTSSADLARMQQIQNSLEIEVNSDGIIAQYEGYFGLKEIDWTAMKEKYGNIYRMDRILKAEGESPDDYKVAKQADTLMLFYNLDKTRVDQILEDLGYQLPADYLEKNLLYYLKRTSHGSTLSRIVHAQLAEMAQFHELSWQLYQEALYSDYRDIQGGTTAEGIHTGVMAATIHVTLATYAGVDTRQNELSICPNLPEHWQALTFQFIHQGVTYQFSLTQTSVTITADRDTQLLVQGALIPLTAERPKEVHYQ
>NZ_CP046113.1|WP_002354877.1|2495294_2496008_-|trehalose-operon-repressor
MNKFHDIFLELEQQIVQGDYQPGDLLPSENQLVETYNVSRETIRKALNLLINAGYIQKKQGKGSIVLNFKKFNFPISGVTSYKELQQTQHIESHTHVVSLEEIPVERNLAQLTGWTEGAPVWRLVRQREIEGEVDILDIDYLIKEIVPELPKHRAEDSIFDYLENDLGLAISYAQKEITVEPLTEMDKQLIGEVEGNHVVVVRSIMNLEDTRCFGYTESRHRLNKFKFVEFARRRKL
>NZ_CP046113.1|WP_025187370.1|2494195_2494894_-|WxL-domain-containing-protein
MKKKMMASLLVGSAVVGASLAPLSAQATTTGNTPVQVEFGGGVLPDHEDNTGENVAPDPTKPNTDFDLLVIPRNFNFSPVKIGEDISAIKLASSLTKTIYVGDVRGTKEGWHVTGEITEMKNAEDSLSGEINFGLTPYYAQYDSTLQGYTATSTLNGVNIVDEPTAPIFSGTNMKIGGGAATLITASVGNGQGTWASGFNNVSLNVTTPMQQIKAGAYTGNITWNLVAGPSI
>NZ_CP046113.1|WP_002378984.1|2493382_2494099_-|WxL-domain-containing-protein
MKKKMMASLLVGSAVVGASLAPLSAQATTTGNTPVTATFEGGTLPDGNGDANTVDPDPNGSNSNFDLLFIPREFNFGKLSISDDLTKPILNQRDPEAINGHTEMIGVGDVRGGKEGWHLTAQSNGLKLGTESLQGNIKVALITQLDLEYEATNNSYVALTTAVSAPEVRPQLAAPQNWTLDLDGEAQLMANAAAGQGQGLWQFSLFNTALNITTPANNIKAGAYTGSITWNLVAGPSV
>NZ_CP046113.1|WP_002359018.1|2492892_2493342_+|large-conductance-mechanosensitive-channel-protein-MscL
MIKEFKEFIMRGSVLDLAVGVVIGSAFTAIVTQVVEGLITPLISLIFVLTTGKKSADDALGALVYKVEGVEFNIGSVISALITFLITAFVLFLIVKAANKMKNRGKKEEAAEEEVVPTSEDYLKEIRDLLAAQTPPAETVKTDSTVTEK
>NZ_CP046113.1|WP_002378983.1|2491415_2492684_-|insulinase-family-protein
MSVQLVKGVNLHVIPTEKYKTVRLLVRFNTRLNHETITKRTLLSSLMETNSLNYPNQVKLSERLAELYGASFGIGVSKKGNQHWFNVSMNIVNDRYLQDSQVLAEAVDFLKEIIFAPNIQAGQFEAETFQREKENLKAYLESIVEDKQTYASLALQSVYFNQSEDQKIPSFGTVAALAEETAASLAAYYQKMLAEDQVDIFVLGDVNEAELVPLFKQLPFTPREEGKAAIFYNQPIRNVIEERTEREVLAQSKLNLAYNTDIYYGDSYYFALQVFNGIFGGFPHSKLFMNVREKEHLAYYASSSIDTFRGFMTVQTGIDGKNRNQVLRLISTELENIRLGKISELEIEQTKAMLKNQYILALDNAGAWLEKEYLNQLMPQTMLTAEEWIARINAVTISEIQEVAKRLELQAIFFLEGETEND
>NZ_CP046113.1|WP_002378981.1|2490118_2491423_-|insulinase-family-protein
MIKKDYAQIKETLYTETLANGLKVYLLPKNDFQKTYGLFTTDYGSIDNTFVPIGQEEMIEVPDGIAHFLEHKMFEKEDGDVFQKFGQQGASANAFTSFTKTSYLFSTTDQVTQNLETLLDFVQSPYFTKETVEKEKGIIGQEIQMYLDDPNWRLFFGILGNLYPKHPLHIDIAGTVASIAEITAEDLYTCYNTFYHPSNMTLFVVGKMDPEALMAFIRENQAAKEFPAAQPIRRHFPEETAADIVKESAIEMAVTRAKVLVGLKGLDEVPTTGRDLMKYQVTVNLLLQLLFGNTSQNYLALYDEGLLDDSFSYDFNLDRSFHFADIGGDSEQPEVLAERIEAILLSATTSPELTEENLSLLKKKMIGKYFQSLNSLEYIANQFSQSLFGETTLFDKIEVIESIQLADVRQVAETFVREEGLSRFYMYPKGETEQ
>NZ_CP046113.1|WP_016633961.1|2489084_2489951_-|helix-turn-helix-domain-containing-protein
MASVNIGETLKEARLQKNISIDELQQMTKIQKRYLEIIEQNDFESLPGTFYVRAFIRQYASAVGLDGNQLVDIYDGKEPAIVEEPKPVYEELEGSRKQLHDEEKQSSWLLRNLPAIAFSLIGLAIAVVVLYIMWQDQKAEPIIQTPATSASVKKPKESSQAPESSTQSSTPPSSSSEPEKKTAVAVVSDANNQVTATVKDANSPINITFKGTEGSCWIGVMVDGNYTYQHTLQAGETQTTALPANAANATLILGASNNVAIQVDGADLTLEKTPVLIRKDVTLGITYR
>NZ_CP046113.1|WP_002359021.1|2488703_2488916_-|hypothetical-protein
MLKIVNKKFNLITIFSIALLVMGFLIVGLQLYFYFIYGSKFLDSITLIGMINLGLGYYQLFLKKGKNISE
>NZ_CP046113.1|WP_002385181.1|2500140_2500734_+|hypothetical-protein
MIEKKDFDTIRKAFLIYDTNFNNHMFTYTYQHRKTKKLLEMNVQFEAGNFMHLCGVDYYQIDKQGSCKFRFKATQFYRALKNNKVSLRGIKPKDDGTTGQKLQVIPLLEMLISPGVRICDGGKFYNLQYEKAIRSGKMIVALTCKENNKKYVPQSLLSLINQPRKSQSKSLTESHEVIKISKSELNSTSVIEVYDKF
>NZ_CP046113.1|WP_002385180.1|2501495_2502029_+|CPBP-family-intramembrane-metalloprotease
MSLIAIKNNEKALIIFDSVLSLIIIIVLSVFYKKIVKKKKQAIFKSLLLAIGMFLFSIILNLLFSRIPTPENQHYINEVRNVAPVLMALHTRLFSPIIEELLTRGIFMNLFFIKNTSRSVLCKIFFSGLFFGLSHGLLPSISMLFYCGMGWVLASTYYFCNNNLTYPLAIHLLLNNL
>NZ_CP046113.1|WP_002381060.1|2502080_2503052_-|ribose-phosphate-diphosphokinase
MSKHYFDPRLKIFSLNSNRPLAEKIADAVGVELGKCSVTQFSDGEIQVNIEESIRGAHVYVIQSTSSPVNDNLMELLIMIDALKRASAKTINVVMPYYGYARQDRKARAREPITAKLVANMIEKAGATRMLTLDLHAVQIQGFFDIPVDHLMGAPLIADYFIEHGIQGDDVVVVSPDHGGVTRARKLAEFLKAPIAIIDKRRPKANVAEVMNIIGHVEGKTCVLIDDMIDTAGTISLAANALKEAGAKDVYASCTHPVLSGPALQRIEDSAIERLVVTDSIYLSDDRKIAKIDEVSVGELIGDAIKRIHENKPVSPLFETKNK
>NZ_CP046113.1|WP_002354871.1|2503226_2503664_-|peptide-methionine-(R)-S-oxide-reductase-MsrB
MTKPTEEELKQTLTDLQYAVTQENATERPFSGEYDDFYQDGIYVDIVSGEPLFSSLDKYDAGCGWPSFTKPIEKRGVKEKADFSHGMHRVEVRSQEADSHLGHVFTDGPLQEGGLRYCINAAALRFVPVADLEKEGYGEYLSLFK
>NZ_CP046113.1|WP_002354869.1|2503796_2504351_-|septum-formation-protein-Maf
MQIILASQSPRRQELLKRVVPTFTIAPADIDETVGKDGLPAEYVAQMAAQKAAAIAEQSPEALVIGCDTIVALAGEILGKPTSREDGYRMLRLLSGKTHDVYTSVTLKQGEKERSATVHSTVTFYPLTDTEIHAYLDTAEYADKAGAYGIQGQGALLIEAIAGDYYAIMGLPIAKVARLLKEFN
>NZ_CP046113.1|WP_002378991.1|2504375_2506508_-|DNA-mismatch-repair-endonuclease-MutL
MGKIQELSEQLANQIAAGEVVERPASVVKELVENALDAGSTQIDIFIEEAGLKTIQIIDNGEGIAKEDVLNAFKRHATSKIHTRDDLFRIRSLGFRGEALPSIASVSEMIVETATAEEEEGSYVILKGGKVEENRPAALRKGTKMTVSNLFYNTPARLKYVKTIQTELANIGDIVNRLALSHPKVAFRLVHDGHKMMSTTGNGDLKQTIAGIYGISTAKKMLKIEGKDLDFTLTGYVSLPEVTRASRNYLSTIINGRYIKNFALNKAIVAGYGSKLMVGRFPIAVLEIEMDPLLVDVNVHPTKQEVRLSKEKDLMALIEQAIQEVLSQEQLIPNAADNLRFKKKLPPEPKAEQMEIPLSTEQPAVKQRPGSLSYNPATGRFYAEHATDETPASSAPEAVNQTERAVDPMDDPFAPPVPESTSVAEETSAYETSSAAADSANHWETASNEQQVIAEETKITEVPDSEPSLRSSEAADEVFQEEMKLHPEFDANSAASQRELKQALNKLEEERPTERFPELEYFGQMHGTYLFAQSKDGLFIIDQHAAQERIKYEYFREKIGEVSDDLQELLVPIVIDYPNSDALKIKEQKETLAEVGIHLEDFGQNSFIVRAHPTWYPAGEEESIVREMIDMLLTTGSVSVKKFREATAIMMSCKRSIKANHYLNEQQARVLLKDLALCENPFNCPHGRPVLIHFTNSDMERMFKRIQDPH
>NZ_CP046113.1|WP_002378992.1|2506539_2509116_-|DNA-mismatch-repair-protein-MutS
MPQKTKNTPMMEQYLSIKAQYKDAFLFYRLGDFYELFYEDAINAAQILELTLTSRNRNADDPIPMCGVPYHAAQGYIDTLIEQGYKVAICEQVEDPKTTKGMVKREVVQLVTPGTVMNSKGLEAKDNNYLTAVLTDGNQFGFAYVDLSTGELKTAVLADEEGVLNEASALQTKEMVLGSGIPESLKENLSLRLNIIFSTQETVEENAEFSFLTNELINPLEIEITGKLLSYLSVTQKRSLSHIQKAVEYQPDHFLKMDHYSKFNLELSQSIRTGQKKGTLLWLLDETKTAMGGRLLKQWLDRPLIQERQIKARQEMVQSLLNAYFERLDLQAALTNVYDLERLAGRVAFGSVNGRDLIQLRTSLEQVPTIRQLIVGINQGEWDDLLVDLNPVEDLVALIATAINEEAPLQITEGKVIKDGYNDQLDEYRDAMRNGKQWLAELEAKERQETGIKNLKIGYNRVFGYFIEITKSNLANLEEGKYERKQTLANAERFITPELKELERLILEAEEKSVELEYQLFLAVREQVKTNIDRLQTLAKTISAVDVLQSFATISERYQYVRPTLRSNTKNLAIVEGRHPVVEKVLGHQEYIPNSIRMNPETDILLITGPNMSGKSTYMRQLALTVVMAQIGCFVPAESAEMPIFDQIFTRIGASDDLIAGQSTFMVEMMEANQALRHATPNSLILFDELGRGTATYDGMALAQAIIEYIHREVQAKTLFSTHYHELTVLDETLKGLKNIHVGAVEKDGEVVFLHKMMEGPADKSYGIHVAKIAGLPSPLLERAATILSALEAEETTIPISVHHEEVSEVHEETEQLSLFKEVSTEELSVIDTLKKMNLLEMTPLDALNMLHQLQKRI
>NZ_CP046113.1|WP_002359008.1|2509116_2509503_-|YlbF-family-regulator
MKVKKMEPLNLDAQSNKELEKLLHLIGQDEVIQRYQAIEEKVKKNKKLTELVEEIKAAQKDAVQFAHYGKPTAEKEAIQRADAKTKEFDEHPLVVAYREQLIEANDLVQHVTALIQYRVNEELEKEGN
>NZ_CP046113.1|WP_002354864.1|2509576_2510374_-|TIGR00282-family-metallophosphoesterase
MRILFIGDVVGSLGREALATYVPKLKKKYRPQVTIANGENAASGRGITGKIYKKFLQDGVDVVTMGNHTWDNKDIFEFIDDAKKMVRPANFPEDVPGQGMVFVKVNQLELAVINLQARTFMVPLEDPFKKAAELVAIARKRTPLIFVDFHGETTSEKQAMSWFLDGQVSAVVGTHTHVQTNDARILPKGTAFLSDVGMTGPYDGILGMKREPIIEKFMTALPKRFEVVETGRTILSACILEIDDQTGQAKMIEPIQISEDRPFQE
>NZ_CP046113.1|WP_002354863.1|2510533_2512090_-|ribonuclease-Y
MVLNILLAIVGLIVGLGLGFVIAKSRHDKAINGAKISASSILENARKESETLKKEALLEAKEENQKYRSEIESELKESRLELKSQENRLIQREQTLDRKDDSLEKREGSLEEKEEKLGARQQLIDEREKEVENLINQQHQELERIASLSKEEAKSIIMKSTEEELNHELTLMVKESEQRAKEESDRKAKNLLSLAIQRCAADSVSETTVSVVTLPNDEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVVLSGFDPIRREIARMTLEKLIQDGRIHPARIEEMVEKSRKEMDERIREYGEQAAFEVGAHTLHPDLIKILGRLRFRTSYGQNVLNHSIEVAKLAGVLAAELGEDVQLAKRAGLLHDIGKALDHEIEGSHVEIGAELAAKYKENSVVINAIASHHGDVEATSVISVLVAAADALSAARPGARSESLENYIRRLENLENISNSFEGVDSSFAVQAGREVRVMVKPEEISDLESVRLVRDIRKKIEDDLDYPGHIKVTVIRETRAVDYAK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP046113_1	1.4\|1459275\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459275-1459304	30	CAJDJX010000002	Enterococcus phage Q69 genome assembly, contig: phageQ69-genome, whole genome shotgun sequence	907-936	0	1.0
NZ_CP046113_1	1.4\|1459275\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459275-1459304	30	MK982307	Enterococcus phage MSF2, complete genome	4970-4999	0	1.0
NZ_CP046113_1	1.4\|1459275\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459275-1459304	30	CAJDKF010000002	Enterococcus phage vB_EfaS_159 genome assembly, contig: phage159-genome, whole genome shotgun sequence	1312-1341	0	1.0
NZ_CP046113_1	1.10\|1459671\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459671-1459700	30	NZ_CP015885	Enterococcus faecalis strain sorialis plasmid Efsorialis-p2, complete sequence	39808-39837	0	1.0
NZ_CP046113_1	1.10\|1459671\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459671-1459700	30	CP002494	Enterococcus faecalis 62 plasmid EF62pC, complete sequence	25370-25399	0	1.0
NZ_CP046113_1	1.10\|1459671\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459671-1459700	30	NZ_LR135294	Enterococcus faecium isolate E7237 plasmid 2	57199-57228	0	1.0
NZ_CP046113_1	1.10\|1459671\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459671-1459700	30	NZ_LR135204	Enterococcus faecium isolate E7171 plasmid 2	60759-60788	0	1.0
NZ_CP046113_1	1.10\|1459671\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459671-1459700	30	NZ_CP031028	Enterococcus faecalis strain TY1 isolate flatfish plasmid pDEF-1, complete sequence	53053-53082	0	1.0
NZ_CP046113_1	1.10\|1459671\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459671-1459700	30	NZ_CP046110	Enterococcus faecalis strain 133170041-3 plasmid pTEF2, complete sequence	16892-16921	0	1.0
NZ_CP046113_1	1.10\|1459671\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459671-1459700	30	NZ_CP019514	Enterococcus faecalis strain CLB21560 plasmid pB, complete sequence	26194-26223	0	1.0
NZ_CP046113_1	1.10\|1459671\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459671-1459700	30	NZ_CP036247	Enterococcus faecalis R712 plasmid pR712_01, complete sequence	7647-7676	0	1.0
NZ_CP046113_1	1.10\|1459671\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459671-1459700	30	NZ_CP008814	Enterococcus faecalis ATCC 29212 plasmid 2, complete sequence	32845-32874	0	1.0
NZ_CP046113_1	1.10\|1459671\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459671-1459700	30	NZ_CP028838	Enterococcus faecalis strain FC plasmid unnamed3, complete sequence	38729-38758	0	1.0
NZ_CP046113_1	1.10\|1459671\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459671-1459700	30	NZ_CP028722	Enterococcus faecalis strain CVM N48037F plasmid pN48037F-2, complete sequence	14953-14982	0	1.0
NZ_CP046113_1	1.10\|1459671\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459671-1459700	30	NZ_CP018066	Enterococcus faecium strain E1 plasmid pE1_230, complete sequence	183599-183628	0	1.0
NZ_CP046113_1	1.11\|1459737\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459737-1459766	30	NZ_CP041739	Enterococcus faecalis EnGen0107 strain B594 plasmid p1, complete sequence	50300-50329	0	1.0
NZ_CP046113_1	1.11\|1459737\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459737-1459766	30	NZ_CP022484	Enterococcus faecalis ARO1/DG plasmid pARO1.1, complete sequence	61986-62015	0	1.0
NZ_CP046113_1	1.11\|1459737\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459737-1459766	30	NC_004669	Enterococcus faecalis V583 plasmid pTEF1, complete sequence	65478-65507	0	1.0
NZ_CP046113_1	1.11\|1459737\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459737-1459766	30	MK784777	Enterococcus faecalis strain E211 plasmid pE211-2, complete sequence	1380-1409	0	1.0
NZ_CP046113_1	1.11\|1459737\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459737-1459766	30	NZ_CP031029	Enterococcus faecalis strain TY1 isolate flatfish plasmid pDEF-2, complete sequence	16353-16382	0	1.0
NZ_CP046113_1	1.11\|1459737\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459737-1459766	30	NZ_CP046110	Enterococcus faecalis strain 133170041-3 plasmid pTEF2, complete sequence	52506-52535	0	1.0
NZ_CP046113_1	1.11\|1459737\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459737-1459766	30	NZ_CP049776	Enterococcus faecalis strain ES-1 plasmid unnamed1, complete sequence	84154-84183	0	1.0
NZ_CP046113_1	1.11\|1459737\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459737-1459766	30	NZ_CP028836	Enterococcus faecalis strain FC plasmid unnamed1, complete sequence	50424-50453	0	1.0
NZ_CP046113_1	1.11\|1459737\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459737-1459766	30	MK465703	Enterococcus faecium strain E505 plasmid pE505-1, complete sequence	44490-44519	0	1.0
NZ_CP046113_1	1.11\|1459737\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459737-1459766	30	MK465704	Enterococcus faecium strain E211 plasmid pE211-2, complete sequence	17024-17053	0	1.0
NZ_CP046113_1	1.11\|1459737\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459737-1459766	30	NZ_KX579977	Enterococcus faecalis strain EF123 plasmid pEF123, complete sequence	74676-74705	0	1.0
NZ_CP046113_1	1.11\|1459737\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459737-1459766	30	NZ_CP019513	Enterococcus faecalis strain CLB21560 plasmid pA, complete sequence	23257-23286	0	1.0
NZ_CP046113_1	1.11\|1459737\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459737-1459766	30	NZ_CP008814	Enterococcus faecalis ATCC 29212 plasmid 2, complete sequence	9140-9169	0	1.0
NZ_CP046113_1	1.11\|1459737\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459737-1459766	30	NZ_CP028286	Enterococcus faecalis strain FDAARGOS_324 plasmid unnamed1, complete sequence	64876-64905	0	1.0
NZ_CP046113_1	1.11\|1459737\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459737-1459766	30	NZ_CP042214	Enterococcus faecalis strain L15 plasmid pL15, complete sequence	56766-56795	0	1.0
NZ_CP046113_1	1.11\|1459737\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459737-1459766	30	MK784778	Enterococcus faecalis strain E508 plasmid pE508-2, complete sequence	30323-30352	0	1.0
NZ_CP046113_1	1.14\|1459935\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459935-1459964	30	NC_028693	Enterococcus phage vB_EfaP_IME195, complete genome	5036-5065	0	1.0
NZ_CP046113_1	1.14\|1459935\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459935-1459964	30	NC_049939	Enterococcus phage vB_EfaP_Ef7.3, complete genome	4808-4837	0	1.0
NZ_CP046113_1	1.14\|1459935\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459935-1459964	30	NC_049935	Enterococcus phage vB_EfaP_Efmus4, complete genome	4363-4392	0	1.0
NZ_CP046113_2	2.3\|1678103\|30\|NZ_CP046113\|CRISPRCasFinder,CRT	1678103-1678132	30	MK721194	Enterococcus phage vB_EfaS_Ef7.1, complete genome	57738-57767	0	1.0
NZ_CP046113_2	2.3\|1678103\|30\|NZ_CP046113\|CRISPRCasFinder,CRT	1678103-1678132	30	NC_041960	Enterococcus phage SAP6, complete genome	13549-13578	0	1.0
NZ_CP046113_2	2.3\|1678103\|30\|NZ_CP046113\|CRISPRCasFinder,CRT	1678103-1678132	30	MN103542	Enterococcus phage vB_EfaS_EF1c55, complete genome	264-293	0	1.0
NZ_CP046113_2	2.5\|1678103\|29\|NZ_CP046113\|PILER-CR	1678103-1678131	29	NC_041960	Enterococcus phage SAP6, complete genome	13550-13578	0	1.0
NZ_CP046113_2	2.5\|1678103\|29\|NZ_CP046113\|PILER-CR	1678103-1678131	29	MN103542	Enterococcus phage vB_EfaS_EF1c55, complete genome	265-293	0	1.0
NZ_CP046113_2	2.5\|1678103\|29\|NZ_CP046113\|PILER-CR	1678103-1678131	29	MK721194	Enterococcus phage vB_EfaS_Ef7.1, complete genome	57738-57766	0	1.0
NZ_CP046113_1	1.4\|1459275\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459275-1459304	30	MK721190	Enterococcus phage vB_EfaS_Ef6.4, complete genome	41009-41038	1	0.967
NZ_CP046113_1	1.5\|1459341\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459341-1459370	30	KJ608188	Enterococcus phage EFC-1, complete genome	12926-12955	1	0.967
NZ_CP046113_1	1.5\|1459341\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459341-1459370	30	NC_028671	Enterococcus phage vB_EfaS_IME197, complete genome	38393-38422	1	0.967
NZ_CP046113_1	1.9\|1459605\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459605-1459634	30	KJ608188	Enterococcus phage EFC-1, complete genome	27114-27143	1	0.967
NZ_CP046113_1	1.14\|1459935\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459935-1459964	30	MK721198	Enterococcus phage vB_EfaP_Ef7.4, complete genome	4382-4411	1	0.967
NZ_CP046113_1	1.9\|1459605\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459605-1459634	30	GQ452243	Enterococcus phage phiEf11, complete genome	10745-10774	2	0.933
NZ_CP046113_2	2.3\|1678103\|30\|NZ_CP046113\|CRISPRCasFinder,CRT	1678103-1678132	30	NC_029016	Enterococcus phage vB_EfaS_IME198, complete genome	5070-5099	2	0.933
NZ_CP046113_2	2.3\|1678103\|30\|NZ_CP046113\|CRISPRCasFinder,CRT	1678103-1678132	30	KY472224	Enterococcus phage EF-P10, complete genome	52824-52853	2	0.933
NZ_CP046113_2	2.3\|1678103\|30\|NZ_CP046113\|CRISPRCasFinder,CRT	1678103-1678132	30	NC_041959	Enterococcus phage IME-EF1, complete genome	12871-12900	2	0.933
NZ_CP046113_2	2.5\|1678103\|29\|NZ_CP046113\|PILER-CR	1678103-1678131	29	KY472224	Enterococcus phage EF-P10, complete genome	52825-52853	2	0.931
NZ_CP046113_2	2.5\|1678103\|29\|NZ_CP046113\|PILER-CR	1678103-1678131	29	NC_041959	Enterococcus phage IME-EF1, complete genome	12872-12900	2	0.931
NZ_CP046113_2	2.5\|1678103\|29\|NZ_CP046113\|PILER-CR	1678103-1678131	29	NC_029016	Enterococcus phage vB_EfaS_IME198, complete genome	5070-5098	2	0.931
NZ_CP046113_1	1.2\|1459143\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459143-1459172	30	Z29674	Bacteriophage FC1 gene for 70kDa protein	802-831	3	0.9
NZ_CP046113_1	1.2\|1459143\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459143-1459172	30	KJ608188	Enterococcus phage EFC-1, complete genome	32425-32454	3	0.9
NZ_CP046113_1	1.2\|1459143\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459143-1459172	30	GQ452243	Enterococcus phage phiEf11, complete genome	16056-16085	3	0.9
NZ_CP046113_1	1.2\|1459143\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459143-1459172	30	NC_028671	Enterococcus phage vB_EfaS_IME197, complete genome	14964-14993	3	0.9
NZ_CP046113_1	1.10\|1459671\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459671-1459700	30	NZ_CP053657	Bacillus cereus strain CTMA_1571 plasmid p.1, complete sequence	414281-414310	4	0.867
NZ_CP046113_2	2.5\|1678103\|29\|NZ_CP046113\|PILER-CR	1678103-1678131	29	MK570225	Enterococcus phage vB_EfaS_PHB08, complete genome	54683-54711	4	0.862
NZ_CP046113_2	2.3\|1678103\|30\|NZ_CP046113\|CRISPRCasFinder,CRT	1678103-1678132	30	MK570225	Enterococcus phage vB_EfaS_PHB08, complete genome	54682-54711	5	0.833
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	LT615366	Enterococcus phage VPE25 genome assembly, chromosome: VPE25	28752-28781	6	0.8
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	LT546029	Enterococcus phage VFW genome assembly, chromosome: VFW	28684-28713	6	0.8
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	LT546030	Enterococcus phage VPE25 genome assembly, chromosome: I	28752-28781	6	0.8
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	MT119361	Enterococus phage vipetofem, complete genome	56526-56555	6	0.8
NZ_CP046113_2	2.1\|1677971\|30\|NZ_CP046113\|CRISPRCasFinder,CRT	1677971-1678000	30	NC_011774	Bacillus cereus G9842 plasmid pG9842_140, complete sequence	45872-45901	6	0.8
NZ_CP046113_1	1.3\|1459209\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459209-1459238	30	LR134125	Klebsiella aerogenes strain NCTC10006 genome assembly, plasmid: 5	680030-680059	7	0.767
NZ_CP046113_1	1.10\|1459671\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459671-1459700	30	NZ_CP016798	Lactobacillus brevis strain TMW 1.2112 plasmid pl12112-1, complete sequence	29811-29840	7	0.767
NZ_CP046113_1	1.10\|1459671\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459671-1459700	30	KJ094028	Listeria phage LP-083-1 contig 2, partial genome	11296-11325	7	0.767
NZ_CP046113_1	1.10\|1459671\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459671-1459700	30	DQ003641	Listeria phage P35, complete genome	27418-27447	7	0.767
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	NZ_CP041427	Escherichia coli strain STEC388 plasmid pSTEC388_2, complete sequence	56283-56312	7	0.767
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	NZ_CP011362	Salimicrobium jeotgali strain MJ3 plasmid pSJ52, complete sequence	1949-1978	7	0.767
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	CP006767	Lactococcus lactis subsp. lactis KLDS 4.0325 plasmid unnamed1, complete sequence	408-437	7	0.767
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	NZ_CP044979	Bacillus thuringiensis strain BT62 plasmid pBT62A, complete sequence	481058-481087	7	0.767
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	NC_004922	Lactococcus lactis lactis BGMN1-5 plasmid pMN5, complete sequence	763-792	7	0.767
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	NZ_CP038659	Citrobacter freundii strain 680 plasmid p680_1, complete sequence	363776-363805	7	0.767
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	NZ_CP016589	Bacillus thuringiensis strain KNU-07 plasmid pBTKNU07-01, complete sequence	106851-106880	7	0.767
NZ_CP046113_1	1.13\|1459869\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459869-1459898	30	MT135024	Vibrio phage V05, complete genome	59483-59512	7	0.767
NZ_CP046113_1	1.13\|1459869\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459869-1459898	30	MT135026	Vibrio phage V09, complete genome	227856-227885	7	0.767
NZ_CP046113_1	1.13\|1459869\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459869-1459898	30	MN794232	Vibrio phage VH1_2019, complete genome	117004-117033	7	0.767
NZ_CP046113_1	1.13\|1459869\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459869-1459898	30	NC_005083	Vibrio phage KVP40, complete genome	116465-116494	7	0.767
NZ_CP046113_1	1.13\|1459869\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459869-1459898	30	JN849462	Vibriophage phi-pp2, complete genome	116408-116437	7	0.767
NZ_CP046113_1	1.13\|1459869\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459869-1459898	30	AY283928	Bacteriophage KVP40, complete genome	116465-116494	7	0.767
NZ_CP046113_1	1.13\|1459869\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459869-1459898	30	MT135025	Vibrio phage V07, complete genome	164567-164596	7	0.767
NZ_CP046113_2	2.1\|1677971\|30\|NZ_CP046113\|CRISPRCasFinder,CRT	1677971-1678000	30	AP013520	Uncultured Mediterranean phage uvMED DNA, complete genome, group G21, isolate: uvMED-CGR-U-MedDCM-OCT-S39-C26	12136-12165	7	0.767
NZ_CP046113_2	2.2\|1678037\|30\|NZ_CP046113\|CRISPRCasFinder,CRT	1678037-1678066	30	NC_015712	Clostridium perfringens plasmid pCPPB-1, complete sequence	62197-62226	7	0.767
NZ_CP046113_2	2.2\|1678037\|30\|NZ_CP046113\|CRISPRCasFinder,CRT	1678037-1678066	30	NC_007772	Clostridium perfringens CPE str. F4969 plasmid pCPF4969, complete sequence	60953-60982	7	0.767
NZ_CP046113_1	1.3\|1459209\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459209-1459238	30	NZ_CP049890	Jeotgalibaca porci strain CCUG 69148 plasmid p_unnamed1, complete sequence	22539-22568	8	0.733
NZ_CP046113_1	1.3\|1459209\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459209-1459238	30	MT889391	Mycobacterium phage MiniMac, complete genome	52585-52614	8	0.733
NZ_CP046113_1	1.3\|1459209\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459209-1459238	30	MT889383	Mycobacterium phage MiniLon, complete genome	52587-52616	8	0.733
NZ_CP046113_1	1.3\|1459209\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459209-1459238	30	KT281791	Mycobacterium phage Lolly9, complete genome	52586-52615	8	0.733
NZ_CP046113_1	1.5\|1459341\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459341-1459370	30	MF001355	Proteus phage PM2, partial genome	16791-16820	8	0.733
NZ_CP046113_1	1.5\|1459341\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459341-1459370	30	KP890823	Proteus phage vB_PmiM_Pm5461, complete genome	29547-29576	8	0.733
NZ_CP046113_1	1.5\|1459341\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459341-1459370	30	JF270478	Psychrobacter phage Psymv2, complete genome	6804-6833	8	0.733
NZ_CP046113_1	1.7\|1459473\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459473-1459502	30	MN176217	Escherichia phage vB_Eco4M-7, complete genome	54013-54042	8	0.733
NZ_CP046113_1	1.7\|1459473\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459473-1459502	30	MH051335	Escherichia phage vB_EcoM-Ro157lw, complete genome	47776-47805	8	0.733
NZ_CP046113_1	1.7\|1459473\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459473-1459502	30	JX128258	Escherichia phage ECML-117, complete genome	52688-52717	8	0.733
NZ_CP046113_1	1.7\|1459473\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459473-1459502	30	NC_048194	Escherichia phage vB_EcoM_WFH, complete genome	47826-47855	8	0.733
NZ_CP046113_1	1.7\|1459473\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459473-1459502	30	MT446405	UNVERIFIED: Escherichia virus TH32, complete genome	47325-47354	8	0.733
NZ_CP046113_1	1.7\|1459473\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459473-1459502	30	MT446408	UNVERIFIED: Escherichia virus TH35, complete genome	8122-8151	8	0.733
NZ_CP046113_1	1.7\|1459473\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459473-1459502	30	NC_048195	Escherichia phage vB_EcoM_WFC, complete genome	47764-47793	8	0.733
NZ_CP046113_1	1.7\|1459473\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459473-1459502	30	NC_048073	Escherichia phage FEC19, complete genome	22675-22704	8	0.733
NZ_CP046113_1	1.7\|1459473\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459473-1459502	30	MT684590	Streptomyces phage LilMartin, complete genome	63102-63131	8	0.733
NZ_CP046113_1	1.7\|1459473\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459473-1459502	30	MT897905	Streptomyces phage MulchMansion, complete genome	63102-63131	8	0.733
NZ_CP046113_1	1.10\|1459671\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459671-1459700	30	MK288021	Bacillus phage pW2, complete genome	140980-141009	8	0.733
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	MN693967	Marine virus AFVG_250M992, complete genome	40288-40317	8	0.733
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	NZ_CP040783	Bacillus thuringiensis strain HM-311 plasmid p1, complete sequence	100498-100527	8	0.733
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	NZ_CP014283	Bacillus thuringiensis strain Bt185 plasmid pBT1850636, complete sequence	303135-303164	8	0.733
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	NZ_CP032614	Bacillus thuringiensis strain QZL38 plasmid p.1, complete sequence	476724-476753	8	0.733
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	CP046512	Bacillus cereus strain JHU plasmid p1, complete sequence	475721-475750	8	0.733
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	NZ_CP011154	Bacillus cereus strain CMCC P0011 plasmid pRML05, complete sequence	336359-336388	8	0.733
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	NZ_CP011152	Bacillus cereus strain CMCC P0021 plasmid pRML04, complete sequence	210527-210556	8	0.733
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	NZ_CP045607	Bacillus cereus strain SB1 plasmid p1, complete sequence	508466-508495	8	0.733
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	NZ_CP050184	Bacillus thuringiensis strain HER1410 plasmid pLUSID1, complete sequence	294951-294980	8	0.733
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	NC_015583	Novosphingobium sp. PP1Y plasmid Mpl, complete sequence	1124729-1124758	8	0.733
NZ_CP046113_1	1.13\|1459869\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459869-1459898	30	KP671755	Vibrio phage ValKK3, complete genome	10086-10115	8	0.733
NZ_CP046113_1	1.1\|1459077\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459077-1459106	30	MG592671	Vibrio phage 2.275.O._10N.286.54.E11, partial genome	257329-257358	9	0.7
NZ_CP046113_1	1.2\|1459143\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459143-1459172	30	MN176217	Escherichia phage vB_Eco4M-7, complete genome	14476-14505	9	0.7
NZ_CP046113_1	1.2\|1459143\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459143-1459172	30	MH051335	Escherichia phage vB_EcoM-Ro157lw, complete genome	8392-8421	9	0.7
NZ_CP046113_1	1.2\|1459143\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459143-1459172	30	JX128258	Escherichia phage ECML-117, complete genome	13174-13203	9	0.7
NZ_CP046113_1	1.2\|1459143\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459143-1459172	30	MK903282	Escherichia phage Mansfield, complete genome	8336-8365	9	0.7
NZ_CP046113_1	1.2\|1459143\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459143-1459172	30	NC_048194	Escherichia phage vB_EcoM_WFH, complete genome	8569-8598	9	0.7
NZ_CP046113_1	1.2\|1459143\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459143-1459172	30	MT446405	UNVERIFIED: Escherichia virus TH32, complete genome	18764-18793	9	0.7
NZ_CP046113_1	1.2\|1459143\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459143-1459172	30	MT446408	UNVERIFIED: Escherichia virus TH35, complete genome	47642-47671	9	0.7
NZ_CP046113_1	1.2\|1459143\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459143-1459172	30	NC_048073	Escherichia phage FEC19, complete genome	61954-61983	9	0.7
NZ_CP046113_1	1.3\|1459209\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459209-1459238	30	NZ_CP009619	Vibrio coralliilyticus strain RE98 plasmid p380, complete sequence	353400-353429	9	0.7
NZ_CP046113_1	1.11\|1459737\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459737-1459766	30	NC_013792	Bacillus pseudofirmus OF4 plasmid pBpOF4-01, complete sequence	229474-229503	9	0.7
NZ_CP046113_1	1.12\|1459803\|30\|NZ_CP046113\|PILER-CR,CRISPRCasFinder,CRT	1459803-1459832	30	CP040041	Acinetobacter baumannii strain VB958 plasmid unnamed1, complete sequence	530179-530208	9	0.7

1. spacer 1.4|1459275|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to CAJDJX010000002 (Enterococcus phage Q69 genome assembly, contig: phageQ69-genome, whole genome shotgun sequence) position: , mismatch: 0, identity: 1.0

ctacctgcatttttaaaggaatgagcgtgg	CRISPR spacer
ctacctgcatttttaaaggaatgagcgtgg	Protospacer
******************************

2. spacer 1.4|1459275|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MK982307 (Enterococcus phage MSF2, complete genome) position: , mismatch: 0, identity: 1.0

ctacctgcatttttaaaggaatgagcgtgg	CRISPR spacer
ctacctgcatttttaaaggaatgagcgtgg	Protospacer
******************************

3. spacer 1.4|1459275|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to CAJDKF010000002 (Enterococcus phage vB_EfaS_159 genome assembly, contig: phage159-genome, whole genome shotgun sequence) position: , mismatch: 0, identity: 1.0

ctacctgcatttttaaaggaatgagcgtgg	CRISPR spacer
ctacctgcatttttaaaggaatgagcgtgg	Protospacer
******************************

4. spacer 1.10|1459671|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015885 (Enterococcus faecalis strain sorialis plasmid Efsorialis-p2, complete sequence) position: , mismatch: 0, identity: 1.0

aatcttctcatttgtattcctccaaaagca	CRISPR spacer
aatcttctcatttgtattcctccaaaagca	Protospacer
******************************

5. spacer 1.10|1459671|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to CP002494 (Enterococcus faecalis 62 plasmid EF62pC, complete sequence) position: , mismatch: 0, identity: 1.0

aatcttctcatttgtattcctccaaaagca	CRISPR spacer
aatcttctcatttgtattcctccaaaagca	Protospacer
******************************

6. spacer 1.10|1459671|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR135294 (Enterococcus faecium isolate E7237 plasmid 2) position: , mismatch: 0, identity: 1.0

aatcttctcatttgtattcctccaaaagca	CRISPR spacer
aatcttctcatttgtattcctccaaaagca	Protospacer
******************************

7. spacer 1.10|1459671|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR135204 (Enterococcus faecium isolate E7171 plasmid 2) position: , mismatch: 0, identity: 1.0

aatcttctcatttgtattcctccaaaagca	CRISPR spacer
aatcttctcatttgtattcctccaaaagca	Protospacer
******************************

8. spacer 1.10|1459671|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP031028 (Enterococcus faecalis strain TY1 isolate flatfish plasmid pDEF-1, complete sequence) position: , mismatch: 0, identity: 1.0

aatcttctcatttgtattcctccaaaagca	CRISPR spacer
aatcttctcatttgtattcctccaaaagca	Protospacer
******************************

9. spacer 1.10|1459671|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP046110 (Enterococcus faecalis strain 133170041-3 plasmid pTEF2, complete sequence) position: , mismatch: 0, identity: 1.0

aatcttctcatttgtattcctccaaaagca	CRISPR spacer
aatcttctcatttgtattcctccaaaagca	Protospacer
******************************

10. spacer 1.10|1459671|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP019514 (Enterococcus faecalis strain CLB21560 plasmid pB, complete sequence) position: , mismatch: 0, identity: 1.0

aatcttctcatttgtattcctccaaaagca	CRISPR spacer
aatcttctcatttgtattcctccaaaagca	Protospacer
******************************

11. spacer 1.10|1459671|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP036247 (Enterococcus faecalis R712 plasmid pR712_01, complete sequence) position: , mismatch: 0, identity: 1.0

aatcttctcatttgtattcctccaaaagca	CRISPR spacer
aatcttctcatttgtattcctccaaaagca	Protospacer
******************************

12. spacer 1.10|1459671|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP008814 (Enterococcus faecalis ATCC 29212 plasmid 2, complete sequence) position: , mismatch: 0, identity: 1.0

aatcttctcatttgtattcctccaaaagca	CRISPR spacer
aatcttctcatttgtattcctccaaaagca	Protospacer
******************************

13. spacer 1.10|1459671|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP028838 (Enterococcus faecalis strain FC plasmid unnamed3, complete sequence) position: , mismatch: 0, identity: 1.0

aatcttctcatttgtattcctccaaaagca	CRISPR spacer
aatcttctcatttgtattcctccaaaagca	Protospacer
******************************

14. spacer 1.10|1459671|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP028722 (Enterococcus faecalis strain CVM N48037F plasmid pN48037F-2, complete sequence) position: , mismatch: 0, identity: 1.0

aatcttctcatttgtattcctccaaaagca	CRISPR spacer
aatcttctcatttgtattcctccaaaagca	Protospacer
******************************

15. spacer 1.10|1459671|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP018066 (Enterococcus faecium strain E1 plasmid pE1_230, complete sequence) position: , mismatch: 0, identity: 1.0

aatcttctcatttgtattcctccaaaagca	CRISPR spacer
aatcttctcatttgtattcctccaaaagca	Protospacer
******************************

16. spacer 1.11|1459737|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP041739 (Enterococcus faecalis EnGen0107 strain B594 plasmid p1, complete sequence) position: , mismatch: 0, identity: 1.0

tgtaattagaagaataaagagctgtatcgg	CRISPR spacer
tgtaattagaagaataaagagctgtatcgg	Protospacer
******************************

17. spacer 1.11|1459737|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP022484 (Enterococcus faecalis ARO1/DG plasmid pARO1.1, complete sequence) position: , mismatch: 0, identity: 1.0

tgtaattagaagaataaagagctgtatcgg	CRISPR spacer
tgtaattagaagaataaagagctgtatcgg	Protospacer
******************************

18. spacer 1.11|1459737|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NC_004669 (Enterococcus faecalis V583 plasmid pTEF1, complete sequence) position: , mismatch: 0, identity: 1.0

tgtaattagaagaataaagagctgtatcgg	CRISPR spacer
tgtaattagaagaataaagagctgtatcgg	Protospacer
******************************

19. spacer 1.11|1459737|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MK784777 (Enterococcus faecalis strain E211 plasmid pE211-2, complete sequence) position: , mismatch: 0, identity: 1.0

tgtaattagaagaataaagagctgtatcgg	CRISPR spacer
tgtaattagaagaataaagagctgtatcgg	Protospacer
******************************

20. spacer 1.11|1459737|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP031029 (Enterococcus faecalis strain TY1 isolate flatfish plasmid pDEF-2, complete sequence) position: , mismatch: 0, identity: 1.0

tgtaattagaagaataaagagctgtatcgg	CRISPR spacer
tgtaattagaagaataaagagctgtatcgg	Protospacer
******************************

21. spacer 1.11|1459737|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP046110 (Enterococcus faecalis strain 133170041-3 plasmid pTEF2, complete sequence) position: , mismatch: 0, identity: 1.0

tgtaattagaagaataaagagctgtatcgg	CRISPR spacer
tgtaattagaagaataaagagctgtatcgg	Protospacer
******************************

22. spacer 1.11|1459737|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP049776 (Enterococcus faecalis strain ES-1 plasmid unnamed1, complete sequence) position: , mismatch: 0, identity: 1.0

tgtaattagaagaataaagagctgtatcgg	CRISPR spacer
tgtaattagaagaataaagagctgtatcgg	Protospacer
******************************

23. spacer 1.11|1459737|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP028836 (Enterococcus faecalis strain FC plasmid unnamed1, complete sequence) position: , mismatch: 0, identity: 1.0

tgtaattagaagaataaagagctgtatcgg	CRISPR spacer
tgtaattagaagaataaagagctgtatcgg	Protospacer
******************************

24. spacer 1.11|1459737|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MK465703 (Enterococcus faecium strain E505 plasmid pE505-1, complete sequence) position: , mismatch: 0, identity: 1.0

tgtaattagaagaataaagagctgtatcgg	CRISPR spacer
tgtaattagaagaataaagagctgtatcgg	Protospacer
******************************

25. spacer 1.11|1459737|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MK465704 (Enterococcus faecium strain E211 plasmid pE211-2, complete sequence) position: , mismatch: 0, identity: 1.0

tgtaattagaagaataaagagctgtatcgg	CRISPR spacer
tgtaattagaagaataaagagctgtatcgg	Protospacer
******************************

26. spacer 1.11|1459737|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_KX579977 (Enterococcus faecalis strain EF123 plasmid pEF123, complete sequence) position: , mismatch: 0, identity: 1.0

tgtaattagaagaataaagagctgtatcgg	CRISPR spacer
tgtaattagaagaataaagagctgtatcgg	Protospacer
******************************

27. spacer 1.11|1459737|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP019513 (Enterococcus faecalis strain CLB21560 plasmid pA, complete sequence) position: , mismatch: 0, identity: 1.0

tgtaattagaagaataaagagctgtatcgg	CRISPR spacer
tgtaattagaagaataaagagctgtatcgg	Protospacer
******************************

28. spacer 1.11|1459737|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP008814 (Enterococcus faecalis ATCC 29212 plasmid 2, complete sequence) position: , mismatch: 0, identity: 1.0

tgtaattagaagaataaagagctgtatcgg	CRISPR spacer
tgtaattagaagaataaagagctgtatcgg	Protospacer
******************************

29. spacer 1.11|1459737|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP028286 (Enterococcus faecalis strain FDAARGOS_324 plasmid unnamed1, complete sequence) position: , mismatch: 0, identity: 1.0

tgtaattagaagaataaagagctgtatcgg	CRISPR spacer
tgtaattagaagaataaagagctgtatcgg	Protospacer
******************************

30. spacer 1.11|1459737|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP042214 (Enterococcus faecalis strain L15 plasmid pL15, complete sequence) position: , mismatch: 0, identity: 1.0

tgtaattagaagaataaagagctgtatcgg	CRISPR spacer
tgtaattagaagaataaagagctgtatcgg	Protospacer
******************************

31. spacer 1.11|1459737|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MK784778 (Enterococcus faecalis strain E508 plasmid pE508-2, complete sequence) position: , mismatch: 0, identity: 1.0

tgtaattagaagaataaagagctgtatcgg	CRISPR spacer
tgtaattagaagaataaagagctgtatcgg	Protospacer
******************************

32. spacer 1.14|1459935|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NC_028693 (Enterococcus phage vB_EfaP_IME195, complete genome) position: , mismatch: 0, identity: 1.0

aatagatgggtaagaactgtttatgtcaaa	CRISPR spacer
aatagatgggtaagaactgtttatgtcaaa	Protospacer
******************************

33. spacer 1.14|1459935|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NC_049939 (Enterococcus phage vB_EfaP_Ef7.3, complete genome) position: , mismatch: 0, identity: 1.0

aatagatgggtaagaactgtttatgtcaaa	CRISPR spacer
aatagatgggtaagaactgtttatgtcaaa	Protospacer
******************************

34. spacer 1.14|1459935|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NC_049935 (Enterococcus phage vB_EfaP_Efmus4, complete genome) position: , mismatch: 0, identity: 1.0

aatagatgggtaagaactgtttatgtcaaa	CRISPR spacer
aatagatgggtaagaactgtttatgtcaaa	Protospacer
******************************

35. spacer 2.3|1678103|30|NZ_CP046113|CRISPRCasFinder,CRT matches to MK721194 (Enterococcus phage vB_EfaS_Ef7.1, complete genome) position: , mismatch: 0, identity: 1.0

gaaaggtgtccgaacagtgtccgcaaggct	CRISPR spacer
gaaaggtgtccgaacagtgtccgcaaggct	Protospacer
******************************

36. spacer 2.3|1678103|30|NZ_CP046113|CRISPRCasFinder,CRT matches to NC_041960 (Enterococcus phage SAP6, complete genome) position: , mismatch: 0, identity: 1.0

gaaaggtgtccgaacagtgtccgcaaggct	CRISPR spacer
gaaaggtgtccgaacagtgtccgcaaggct	Protospacer
******************************

37. spacer 2.3|1678103|30|NZ_CP046113|CRISPRCasFinder,CRT matches to MN103542 (Enterococcus phage vB_EfaS_EF1c55, complete genome) position: , mismatch: 0, identity: 1.0

gaaaggtgtccgaacagtgtccgcaaggct	CRISPR spacer
gaaaggtgtccgaacagtgtccgcaaggct	Protospacer
******************************

38. spacer 2.5|1678103|29|NZ_CP046113|PILER-CR matches to NC_041960 (Enterococcus phage SAP6, complete genome) position: , mismatch: 0, identity: 1.0

gaaaggtgtccgaacagtgtccgcaaggc	CRISPR spacer
gaaaggtgtccgaacagtgtccgcaaggc	Protospacer
*****************************

39. spacer 2.5|1678103|29|NZ_CP046113|PILER-CR matches to MN103542 (Enterococcus phage vB_EfaS_EF1c55, complete genome) position: , mismatch: 0, identity: 1.0

gaaaggtgtccgaacagtgtccgcaaggc	CRISPR spacer
gaaaggtgtccgaacagtgtccgcaaggc	Protospacer
*****************************

40. spacer 2.5|1678103|29|NZ_CP046113|PILER-CR matches to MK721194 (Enterococcus phage vB_EfaS_Ef7.1, complete genome) position: , mismatch: 0, identity: 1.0

gaaaggtgtccgaacagtgtccgcaaggc	CRISPR spacer
gaaaggtgtccgaacagtgtccgcaaggc	Protospacer
*****************************

41. spacer 1.4|1459275|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MK721190 (Enterococcus phage vB_EfaS_Ef6.4, complete genome) position: , mismatch: 1, identity: 0.967

ctacctgcatttttaaaggaatgagcgtgg	CRISPR spacer
ctacctgcatttttaaaggaatgtgcgtgg	Protospacer
*********************** ******

42. spacer 1.5|1459341|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to KJ608188 (Enterococcus phage EFC-1, complete genome) position: , mismatch: 1, identity: 0.967

attatcagatgctaaacgtaatgcagattg	CRISPR spacer
attatcagatgctaaacgtaatgcagattt	Protospacer
*****************************

43. spacer 1.5|1459341|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NC_028671 (Enterococcus phage vB_EfaS_IME197, complete genome) position: , mismatch: 1, identity: 0.967

attatcagatgctaaacgtaatgcagattg	CRISPR spacer
attatcagatgctaaacgtaatgcagattt	Protospacer
*****************************

44. spacer 1.9|1459605|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to KJ608188 (Enterococcus phage EFC-1, complete genome) position: , mismatch: 1, identity: 0.967

agccaagattgaagatagaggtctctttca	CRISPR spacer
agccaagattggagatagaggtctctttca	Protospacer
***********.******************

45. spacer 1.14|1459935|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MK721198 (Enterococcus phage vB_EfaP_Ef7.4, complete genome) position: , mismatch: 1, identity: 0.967

aatagatgggtaagaactgtttatgtcaaa	CRISPR spacer
aatagatgggtaagaactgttaatgtcaaa	Protospacer
********************* ********

46. spacer 1.9|1459605|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to GQ452243 (Enterococcus phage phiEf11, complete genome) position: , mismatch: 2, identity: 0.933

agccaagattgaagatagaggtctctttca	CRISPR spacer
agccaagcttggagatagaggtctctttca	Protospacer
******* ***.******************

47. spacer 2.3|1678103|30|NZ_CP046113|CRISPRCasFinder,CRT matches to NC_029016 (Enterococcus phage vB_EfaS_IME198, complete genome) position: , mismatch: 2, identity: 0.933

gaaaggtgtccgaacagtgtccgcaaggct	CRISPR spacer
gaaaggtgtccgaacgctgtccgcaaggct	Protospacer
***************. *************

48. spacer 2.3|1678103|30|NZ_CP046113|CRISPRCasFinder,CRT matches to KY472224 (Enterococcus phage EF-P10, complete genome) position: , mismatch: 2, identity: 0.933

gaaaggtgtccgaacagtgtccgcaaggct	CRISPR spacer
gaaaggtgtccgaacgctgtccgcaaggct	Protospacer
***************. *************

49. spacer 2.3|1678103|30|NZ_CP046113|CRISPRCasFinder,CRT matches to NC_041959 (Enterococcus phage IME-EF1, complete genome) position: , mismatch: 2, identity: 0.933

gaaaggtgtccgaacagtgtccgcaaggct	CRISPR spacer
gaaagcagtccgaacagtgtccgcaaggct	Protospacer
*****  ***********************

50. spacer 2.5|1678103|29|NZ_CP046113|PILER-CR matches to KY472224 (Enterococcus phage EF-P10, complete genome) position: , mismatch: 2, identity: 0.931

gaaaggtgtccgaacagtgtccgcaaggc	CRISPR spacer
gaaaggtgtccgaacgctgtccgcaaggc	Protospacer
***************. ************

51. spacer 2.5|1678103|29|NZ_CP046113|PILER-CR matches to NC_041959 (Enterococcus phage IME-EF1, complete genome) position: , mismatch: 2, identity: 0.931

gaaaggtgtccgaacagtgtccgcaaggc	CRISPR spacer
gaaagcagtccgaacagtgtccgcaaggc	Protospacer
*****  **********************

52. spacer 2.5|1678103|29|NZ_CP046113|PILER-CR matches to NC_029016 (Enterococcus phage vB_EfaS_IME198, complete genome) position: , mismatch: 2, identity: 0.931

gaaaggtgtccgaacagtgtccgcaaggc	CRISPR spacer
gaaaggtgtccgaacgctgtccgcaaggc	Protospacer
***************. ************

53. spacer 1.2|1459143|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to Z29674 (Bacteriophage FC1 gene for 70kDa protein) position: , mismatch: 3, identity: 0.9

atgggtggaccaacgattcacagttccgca	CRISPR spacer
ttgggtagaccaacgattcacagttccaca	Protospacer
 *****.********************.**

54. spacer 1.2|1459143|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to KJ608188 (Enterococcus phage EFC-1, complete genome) position: , mismatch: 3, identity: 0.9

atgggtggaccaacgattcacagttccgca	CRISPR spacer
ttgggtagaccaacgattcacagttccaca	Protospacer
 *****.********************.**

55. spacer 1.2|1459143|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to GQ452243 (Enterococcus phage phiEf11, complete genome) position: , mismatch: 3, identity: 0.9

atgggtggaccaacgattcacagttccgca	CRISPR spacer
ttgggtcgaccaacgattcacagttccaca	Protospacer
 ***** ********************.**

56. spacer 1.2|1459143|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NC_028671 (Enterococcus phage vB_EfaS_IME197, complete genome) position: , mismatch: 3, identity: 0.9

atgggtggaccaacgattcacagttccgca	CRISPR spacer
ttgggtagaccaacgattcacagttccaca	Protospacer
 *****.********************.**

57. spacer 1.10|1459671|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP053657 (Bacillus cereus strain CTMA_1571 plasmid p.1, complete sequence) position: , mismatch: 4, identity: 0.867

aatcttctcatttgtattcctccaaaagca	CRISPR spacer
aatattctcatttgtattcctccatattca	Protospacer
*** ******************** *  **

58. spacer 2.5|1678103|29|NZ_CP046113|PILER-CR matches to MK570225 (Enterococcus phage vB_EfaS_PHB08, complete genome) position: , mismatch: 4, identity: 0.862

gaaaggtgtccgaacagtgtccgcaaggc	CRISPR spacer
gaaaggtgtccgaacgctgtccgcaaagg	Protospacer
***************. *********.*

59. spacer 2.3|1678103|30|NZ_CP046113|CRISPRCasFinder,CRT matches to MK570225 (Enterococcus phage vB_EfaS_PHB08, complete genome) position: , mismatch: 5, identity: 0.833

gaaaggtgtccgaacagtgtccgcaaggct	CRISPR spacer
gaaaggtgtccgaacgctgtccgcaaaggc	Protospacer
***************. *********.* .

60. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to LT615366 (Enterococcus phage VPE25 genome assembly, chromosome: VPE25) position: , mismatch: 6, identity: 0.8

ctttcaaa----agaaaataattgattcaattga	CRISPR spacer
----taaagtggagaaaataattgatttaattga	Protospacer
    .***    ***************.******

61. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to LT546029 (Enterococcus phage VFW genome assembly, chromosome: VFW) position: , mismatch: 6, identity: 0.8

ctttcaaa----agaaaataattgattcaattga	CRISPR spacer
----taaagtggagaaaataattgatttaattga	Protospacer
    .***    ***************.******

62. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to LT546030 (Enterococcus phage VPE25 genome assembly, chromosome: I) position: , mismatch: 6, identity: 0.8

ctttcaaa----agaaaataattgattcaattga	CRISPR spacer
----taaagtggagaaaataattgatttaattga	Protospacer
    .***    ***************.******

63. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MT119361 (Enterococus phage vipetofem, complete genome) position: , mismatch: 6, identity: 0.8

ctttcaaa----agaaaataattgattcaattga	CRISPR spacer
----taaagtggagaaaataattgatttaattga	Protospacer
    .***    ***************.******

64. spacer 2.1|1677971|30|NZ_CP046113|CRISPRCasFinder,CRT matches to NC_011774 (Bacillus cereus G9842 plasmid pG9842_140, complete sequence) position: , mismatch: 6, identity: 0.8

tcatcatagtatcgtaaaactctttctggt	CRISPR spacer
ccatcatagtaacgtaaaactcgttctaca	Protospacer
.********** ********** ****.

65. spacer 1.3|1459209|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to LR134125 (Klebsiella aerogenes strain NCTC10006 genome assembly, plasmid: 5) position: , mismatch: 7, identity: 0.767

gcttcggcaatggttacatcagcagttaaa	CRISPR spacer
gcttcggtaacggttacatcagcctgttca	Protospacer
*******.**.************   *  *

66. spacer 1.10|1459671|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP016798 (Lactobacillus brevis strain TMW 1.2112 plasmid pl12112-1, complete sequence) position: , mismatch: 7, identity: 0.767

aatcttctcatttgtattcctccaaaagca	CRISPR spacer
tctcttttcatttgtcttcctccaaaacat	Protospacer
  ****.******** ***********

67. spacer 1.10|1459671|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to KJ094028 (Listeria phage LP-083-1 contig 2, partial genome) position: , mismatch: 7, identity: 0.767

aatcttctcatttgtattcctccaaaagca	CRISPR spacer
acttctctcatttccattcctccaaaagtg	Protospacer
* *..******** .*************..

68. spacer 1.10|1459671|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to DQ003641 (Listeria phage P35, complete genome) position: , mismatch: 7, identity: 0.767

aatcttctcatttgtattcctccaaaagca	CRISPR spacer
acttctctcatttccattcctccaaaagtg	Protospacer
* *..******** .*************..

69. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP041427 (Escherichia coli strain STEC388 plasmid pSTEC388_2, complete sequence) position: , mismatch: 7, identity: 0.767

ctttcaaaagaaaataattgattcaattga	CRISPR spacer
tccacaaaagaaaataatttatttaattca	Protospacer
... *************** ***.**** *

70. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP011362 (Salimicrobium jeotgali strain MJ3 plasmid pSJ52, complete sequence) position: , mismatch: 7, identity: 0.767

ctttcaaaagaaaataattgattcaattga	CRISPR spacer
ggctgaaaagaaaatatttaattcaattgg	Protospacer
  .* *********** **.*********.

71. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to CP006767 (Lactococcus lactis subsp. lactis KLDS 4.0325 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

---ctttcaaaagaaaataattgattcaattga	CRISPR spacer
aaatttt---aagaaaattattgattcaattag	Protospacer
   .***   ******** ************..

72. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP044979 (Bacillus thuringiensis strain BT62 plasmid pBT62A, complete sequence) position: , mismatch: 7, identity: 0.767

ctttcaaaagaaaataattgattcaattga	CRISPR spacer
ctttcaaaagaaaaaaattaattaacacgt	Protospacer
************** ****.*** *  .*

73. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NC_004922 (Lactococcus lactis lactis BGMN1-5 plasmid pMN5, complete sequence) position: , mismatch: 7, identity: 0.767

---ctttcaaaagaaaataattgattcaattga	CRISPR spacer
aaatttt---aagaaaattattgattcaattag	Protospacer
   .***   ******** ************..

74. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP038659 (Citrobacter freundii strain 680 plasmid p680_1, complete sequence) position: , mismatch: 7, identity: 0.767

ctttcaaaagaaaataattgattcaattga	CRISPR spacer
atttcaaaagaaattaattgatgctgatta	Protospacer
 ************ ******** * . * *

75. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP016589 (Bacillus thuringiensis strain KNU-07 plasmid pBTKNU07-01, complete sequence) position: , mismatch: 7, identity: 0.767

ctttcaaaagaaaataattgattcaattga	CRISPR spacer
ctttcaaaagaaaaaaattaattaacacgt	Protospacer
************** ****.*** *  .*

76. spacer 1.13|1459869|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MT135024 (Vibrio phage V05, complete genome) position: , mismatch: 7, identity: 0.767

tcgtctgtgcgccgaatagataaagaggtg	CRISPR spacer
tgaccggtgcgccgactagataaacaggta	Protospacer
* ..* ********* ******** ****.

77. spacer 1.13|1459869|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MT135026 (Vibrio phage V09, complete genome) position: , mismatch: 7, identity: 0.767

tcgtctgtgcgccgaatagataaagaggtg	CRISPR spacer
tgaccggtgcgccgactagataaacaggta	Protospacer
* ..* ********* ******** ****.

78. spacer 1.13|1459869|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MN794232 (Vibrio phage VH1_2019, complete genome) position: , mismatch: 7, identity: 0.767

tcgtctgtgcgccgaatagataaagaggtg	CRISPR spacer
tgaccggtgcgccgactagataaacaggta	Protospacer
* ..* ********* ******** ****.

79. spacer 1.13|1459869|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NC_005083 (Vibrio phage KVP40, complete genome) position: , mismatch: 7, identity: 0.767

tcgtctgtgcgccgaatagataaagaggtg	CRISPR spacer
tgcacggtgcgccgactagataaacaggta	Protospacer
*   * ********* ******** ****.

80. spacer 1.13|1459869|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to JN849462 (Vibriophage phi-pp2, complete genome) position: , mismatch: 7, identity: 0.767

tcgtctgtgcgccgaatagataaagaggtg	CRISPR spacer
tgcacggtgcgccgactagataaacaggta	Protospacer
*   * ********* ******** ****.

81. spacer 1.13|1459869|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to AY283928 (Bacteriophage KVP40, complete genome) position: , mismatch: 7, identity: 0.767

tcgtctgtgcgccgaatagataaagaggtg	CRISPR spacer
tgcacggtgcgccgactagataaacaggta	Protospacer
*   * ********* ******** ****.

82. spacer 1.13|1459869|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MT135025 (Vibrio phage V07, complete genome) position: , mismatch: 7, identity: 0.767

tcgtctgtgcgccgaatagataaagaggtg	CRISPR spacer
tgcacggtgcgccgactagataaacaggta	Protospacer
*   * ********* ******** ****.

83. spacer 2.1|1677971|30|NZ_CP046113|CRISPRCasFinder,CRT matches to AP013520 (Uncultured Mediterranean phage uvMED DNA, complete genome, group G21, isolate: uvMED-CGR-U-MedDCM-OCT-S39-C26) position: , mismatch: 7, identity: 0.767

tcatcatagtatcgtaaaactctttctggt	CRISPR spacer
ctaaaatagtatcgtaaaactttttctttt	Protospacer
..*  ****************.*****  *

84. spacer 2.2|1678037|30|NZ_CP046113|CRISPRCasFinder,CRT matches to NC_015712 (Clostridium perfringens plasmid pCPPB-1, complete sequence) position: , mismatch: 7, identity: 0.767

ttattgcttcacctattggaattgtaattg	CRISPR spacer
ataaaatttcacctattggtattttaattg	Protospacer
 **  ..************ *** ******

85. spacer 2.2|1678037|30|NZ_CP046113|CRISPRCasFinder,CRT matches to NC_007772 (Clostridium perfringens CPE str. F4969 plasmid pCPF4969, complete sequence) position: , mismatch: 7, identity: 0.767

ttattgcttcacctattggaattgtaattg	CRISPR spacer
ataaaatttcacctattggtattttaattg	Protospacer
 **  ..************ *** ******

86. spacer 1.3|1459209|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP049890 (Jeotgalibaca porci strain CCUG 69148 plasmid p_unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

gcttcggcaatggttacatcagcagttaaa	CRISPR spacer
actaaaccaatggttacatcagtagttatt	Protospacer
.**  . ***************.*****

87. spacer 1.3|1459209|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MT889391 (Mycobacterium phage MiniMac, complete genome) position: , mismatch: 8, identity: 0.733

gcttcggcaatggttacatcagcagttaaa	CRISPR spacer
ctttcggcaatggttacctcagcctcaaac	Protospacer
 .*************** *****  . **

88. spacer 1.3|1459209|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MT889383 (Mycobacterium phage MiniLon, complete genome) position: , mismatch: 8, identity: 0.733

gcttcggcaatggttacatcagcagttaaa	CRISPR spacer
ctttcggcaatggttacctcagcctcaaac	Protospacer
 .*************** *****  . **

89. spacer 1.3|1459209|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to KT281791 (Mycobacterium phage Lolly9, complete genome) position: , mismatch: 8, identity: 0.733

gcttcggcaatggttacatcagcagttaaa	CRISPR spacer
ctttcggcaatggttacctcagcctcaaac	Protospacer
 .*************** *****  . **

90. spacer 1.5|1459341|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MF001355 (Proteus phage PM2, partial genome) position: , mismatch: 8, identity: 0.733

attatcagatgctaaacgtaatgcagattg	CRISPR spacer
tatgttagctgctaaacgtaatgcagaact	Protospacer
  *.*.** ****************** .

91. spacer 1.5|1459341|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to KP890823 (Proteus phage vB_PmiM_Pm5461, complete genome) position: , mismatch: 8, identity: 0.733

attatcagatgctaaacgtaatgcagattg	CRISPR spacer
tatgttagctgctaaacgtaatgcagaact	Protospacer
  *.*.** ****************** .

92. spacer 1.5|1459341|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to JF270478 (Psychrobacter phage Psymv2, complete genome) position: , mismatch: 8, identity: 0.733

attatcagatgctaaacgtaatgcagattg	CRISPR spacer
ctgatcagcagctaaacgtaatgcagcaga	Protospacer
 * *****  ****************   .

93. spacer 1.7|1459473|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MN176217 (Escherichia phage vB_Eco4M-7, complete genome) position: , mismatch: 8, identity: 0.733

cagagtttcaagagctgcatgaattattcg	CRISPR spacer
ttaagcttcaagagctgtatgaattatatt	Protospacer
. .**.***********.********* .

94. spacer 1.7|1459473|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MH051335 (Escherichia phage vB_EcoM-Ro157lw, complete genome) position: , mismatch: 8, identity: 0.733

cagagtttcaagagctgcatgaattattcg	CRISPR spacer
ttaagcttcaagagctgtatgaattatatt	Protospacer
. .**.***********.********* .

95. spacer 1.7|1459473|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to JX128258 (Escherichia phage ECML-117, complete genome) position: , mismatch: 8, identity: 0.733

cagagtttcaagagctgcatgaattattcg	CRISPR spacer
ttaagcttcaagagctgtatgaattatatt	Protospacer
. .**.***********.********* .

96. spacer 1.7|1459473|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NC_048194 (Escherichia phage vB_EcoM_WFH, complete genome) position: , mismatch: 8, identity: 0.733

cagagtttcaagagctgcatgaattattcg	CRISPR spacer
ttaagcttcaagagctgtatgaattatatt	Protospacer
. .**.***********.********* .

97. spacer 1.7|1459473|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MT446405 (UNVERIFIED: Escherichia virus TH32, complete genome) position: , mismatch: 8, identity: 0.733

cagagtttcaagagctgcatgaattattcg	CRISPR spacer
ttaagcttcaagagctgtatgaattatatt	Protospacer
. .**.***********.********* .

98. spacer 1.7|1459473|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MT446408 (UNVERIFIED: Escherichia virus TH35, complete genome) position: , mismatch: 8, identity: 0.733

cagagtttcaagagctgcatgaattattcg	CRISPR spacer
ttaagcttcaagagctgtatgaattatatt	Protospacer
. .**.***********.********* .

99. spacer 1.7|1459473|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NC_048195 (Escherichia phage vB_EcoM_WFC, complete genome) position: , mismatch: 8, identity: 0.733

cagagtttcaagagctgcatgaattattcg	CRISPR spacer
ttaagcttcaagagctgtatgaattatatt	Protospacer
. .**.***********.********* .

100. spacer 1.7|1459473|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NC_048073 (Escherichia phage FEC19, complete genome) position: , mismatch: 8, identity: 0.733

cagagtttcaagagctgcatgaattattcg	CRISPR spacer
ttaagcttcaagagctgtatgaattatatt	Protospacer
. .**.***********.********* .

101. spacer 1.7|1459473|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MT684590 (Streptomyces phage LilMartin, complete genome) position: , mismatch: 8, identity: 0.733

cagagtttcaagagctgcatgaattattcg	CRISPR spacer
gggagtttcaagagcttcatgatttcatga	Protospacer
 .************** ***** **  * .

102. spacer 1.7|1459473|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MT897905 (Streptomyces phage MulchMansion, complete genome) position: , mismatch: 8, identity: 0.733

cagagtttcaagagctgcatgaattattcg	CRISPR spacer
gggagtttcaagagcttcatgatttcatga	Protospacer
 .************** ***** **  * .

103. spacer 1.10|1459671|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MK288021 (Bacillus phage pW2, complete genome) position: , mismatch: 8, identity: 0.733

aatcttctcatttgtattcctccaaaagca-----	CRISPR spacer
aattttctcatttatattcctcc-----cttttat	Protospacer
***.*********.*********     *

104. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MN693967 (Marine virus AFVG_250M992, complete genome) position: , mismatch: 8, identity: 0.733

ctttcaaaagaaaataattgattcaattga	CRISPR spacer
tttttaaaagaaaataatggattcacagct	Protospacer
.***.************* ******

105. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP040783 (Bacillus thuringiensis strain HM-311 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.733

ctttcaaaagaaaataattgattcaattga	CRISPR spacer
ctttcaaaagaaaaaaattaattaccgcgt	Protospacer
************** ****.***    .*

106. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014283 (Bacillus thuringiensis strain Bt185 plasmid pBT1850636, complete sequence) position: , mismatch: 8, identity: 0.733

ctttcaaaagaaaataattgattcaattga	CRISPR spacer
ctttcaaaagaaaaaaattaattaccgcgt	Protospacer
************** ****.***    .*

107. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032614 (Bacillus thuringiensis strain QZL38 plasmid p.1, complete sequence) position: , mismatch: 8, identity: 0.733

ctttcaaaagaaaataattgattcaattga	CRISPR spacer
ctttcaaaagaaaaaaattaattaccgcgt	Protospacer
************** ****.***    .*

108. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to CP046512 (Bacillus cereus strain JHU plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.733

ctttcaaaagaaaataattgattcaattga	CRISPR spacer
ctttcaaaagaaaaaaattaattaccgcgt	Protospacer
************** ****.***    .*

109. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP011154 (Bacillus cereus strain CMCC P0011 plasmid pRML05, complete sequence) position: , mismatch: 8, identity: 0.733

ctttcaaaagaaaataattgattcaattga	CRISPR spacer
ctttcaaaagaaaaaaattaattaccacgt	Protospacer
************** ****.***    .*

110. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP011152 (Bacillus cereus strain CMCC P0021 plasmid pRML04, complete sequence) position: , mismatch: 8, identity: 0.733

ctttcaaaagaaaataattgattcaattga	CRISPR spacer
ctttcaaaagaaaaaaattaattaccacgt	Protospacer
************** ****.***    .*

111. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP045607 (Bacillus cereus strain SB1 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.733

ctttcaaaagaaaataattgattcaattga	CRISPR spacer
ctttcaaaagaaaaaaattaattaccacgt	Protospacer
************** ****.***    .*

112. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP050184 (Bacillus thuringiensis strain HER1410 plasmid pLUSID1, complete sequence) position: , mismatch: 8, identity: 0.733

ctttcaaaagaaaataattgattcaattga	CRISPR spacer
ctttcaaaagaaaaaaattaattaccgcgt	Protospacer
************** ****.***    .*

113. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NC_015583 (Novosphingobium sp. PP1Y plasmid Mpl, complete sequence) position: , mismatch: 8, identity: 0.733

ctttcaaaagaaaataattgattcaattga	CRISPR spacer
aacgaaaaagaaaataattgatttagttaa	Protospacer
  .  ******************.*.**.*

114. spacer 1.13|1459869|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to KP671755 (Vibrio phage ValKK3, complete genome) position: , mismatch: 8, identity: 0.733

tcgtctgtgcgccgaatagataaagaggtg	CRISPR spacer
tgacaggtgcgccgactagataaacaggta	Protospacer
* ..  ********* ******** ****.

115. spacer 1.1|1459077|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MG592671 (Vibrio phage 2.275.O._10N.286.54.E11, partial genome) position: , mismatch: 9, identity: 0.7

aatttcagattacgaattaacagaaataaa	CRISPR spacer
gcagtagcgttaggaattaacagaaataaa	Protospacer
.   * . .*** *****************

116. spacer 1.2|1459143|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MN176217 (Escherichia phage vB_Eco4M-7, complete genome) position: , mismatch: 9, identity: 0.7

atgggtggaccaacgattcacagttccgca	CRISPR spacer
ccaactgcaccaacgattcacagttcgcct	Protospacer
 ... ** ******************  *

117. spacer 1.2|1459143|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MH051335 (Escherichia phage vB_EcoM-Ro157lw, complete genome) position: , mismatch: 9, identity: 0.7

atgggtggaccaacgattcacagttccgca	CRISPR spacer
ccaactgcaccaacgattcacagttcgcct	Protospacer
 ... ** ******************  *

118. spacer 1.2|1459143|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to JX128258 (Escherichia phage ECML-117, complete genome) position: , mismatch: 9, identity: 0.7

atgggtggaccaacgattcacagttccgca	CRISPR spacer
ccaactgcaccaacgattcacagttcacct	Protospacer
 ... ** ******************  *

119. spacer 1.2|1459143|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MK903282 (Escherichia phage Mansfield, complete genome) position: , mismatch: 9, identity: 0.7

atgggtggaccaacgattcacagttccgca	CRISPR spacer
ccaactgcaccaacgattcacagttcacct	Protospacer
 ... ** ******************  *

120. spacer 1.2|1459143|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NC_048194 (Escherichia phage vB_EcoM_WFH, complete genome) position: , mismatch: 9, identity: 0.7

atgggtggaccaacgattcacagttccgca	CRISPR spacer
ccaactgcaccaacgattcacagttcatct	Protospacer
 ... ** ******************  *

121. spacer 1.2|1459143|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MT446405 (UNVERIFIED: Escherichia virus TH32, complete genome) position: , mismatch: 9, identity: 0.7

atgggtggaccaacgattcacagttccgca	CRISPR spacer
ccaactgcaccaacgattcacagttcgtct	Protospacer
 ... ** ******************  *

122. spacer 1.2|1459143|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to MT446408 (UNVERIFIED: Escherichia virus TH35, complete genome) position: , mismatch: 9, identity: 0.7

atgggtggaccaacgattcacagttccgca	CRISPR spacer
ccaactgcaccaacgattcacagttcgcct	Protospacer
 ... ** ******************  *

123. spacer 1.2|1459143|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NC_048073 (Escherichia phage FEC19, complete genome) position: , mismatch: 9, identity: 0.7

atgggtggaccaacgattcacagttccgca	CRISPR spacer
ccaactgcaccaacgattcacagttcgtct	Protospacer
 ... ** ******************  *

124. spacer 1.3|1459209|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009619 (Vibrio coralliilyticus strain RE98 plasmid p380, complete sequence) position: , mismatch: 9, identity: 0.7

gcttcggcaatggttacatcagcagttaaa	CRISPR spacer
ttaccatcaatgcttacatcagcagttagt	Protospacer
 . .*. ***** ***************.

125. spacer 1.11|1459737|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to NC_013792 (Bacillus pseudofirmus OF4 plasmid pBpOF4-01, complete sequence) position: , mismatch: 9, identity: 0.7

tgtaattagaagaataaagagctgtatcgg	CRISPR spacer
aaggtttagaagaattaagagctgtaggga	Protospacer
 . . ********** **********  *.

126. spacer 1.12|1459803|30|NZ_CP046113|PILER-CR,CRISPRCasFinder,CRT matches to CP040041 (Acinetobacter baumannii strain VB958 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.7

ctttcaaaagaaaataattgattcaattga	CRISPR spacer
taaagataagaaaataattgatttaattcc	Protospacer
.    * ****************.****

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

678434 : 686354

Planktothrix_phage(16.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002355794.1\|678434_679493_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.0e-17	30.1
WP_002355795.1\|679492_680449_+	ATP-binding cassette domain-containing protein	A0A1J0FA64	Only_Syngen_Nebraska_virus	3.2e-06	23.9
WP_002355796.1\|680489_681560_+	helix-turn-helix domain-containing protein	A0A288TXV8	Enterococcus_phage	7.6e-89	49.0
WP_002355797.1\|681959_682481_+	translation initiation factor IF-3	A0A2L0UZ54	Agrobacterium_phage	3.0e-14	33.3
WP_002355798.1\|682594_682795_+	50S ribosomal protein L35	NA	NA	NA	NA
WP_002355799.1\|682855_683215_+	50S ribosomal protein L20	NA	NA	NA	NA
WP_002385048.1\|683260_683641_-	MmcQ/YjbR family DNA-binding protein	NA	NA	NA	NA
WP_002361363.1\|683708_684068_+	DUF1304 domain-containing protein	NA	NA	NA	NA
WP_025187394.1\|684135_684630_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_002379186.1\|684647_685163_+	GrpB family protein	A0A2K5B2B6	Erysipelothrix_phage	1.0e-38	48.8
WP_002380126.1\|685178_686354_-	SulP family inorganic anion transporter	A0A2H4J153	uncultured_Caudovirales_phage	3.3e-85	47.7

DBSCAN-SWA_2

1043205 : 1060978

Enterococcus_phage(46.15%)

tail,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002357859.1\|1043205_1045602_+	translation initiation factor IF-2	A0A2H4UTS4	Bodo_saltans_virus	1.7e-19	24.1
WP_002360497.1\|1045626_1045977_+	30S ribosome-binding factor RbfA	NA	NA	NA	NA
WP_002382232.1\|1046349_1046835_-	toxin	A0A097BY56	Enterococcus_phage	4.4e-60	70.5
WP_002360496.1\|1046869_1047352_-	helix-turn-helix domain-containing protein	R9QTP6	Staphylococcus_phage	2.6e-20	47.7
WP_002382234.1\|1047749_1048505_+	DnaD domain protein	A0A0K0MX39	Streptococcus_phage	6.7e-31	56.0
WP_002379370.1\|1048523_1049366_+	ATP-binding protein	A0A0P0I3L9	Lactobacillus_phage	5.7e-31	31.0
WP_002360492.1\|1049432_1049825_+	hypothetical protein	NA	NA	NA	NA
WP_002379371.1\|1049844_1050252_+	RinA family phage transcriptional activator	NA	NA	NA	NA
WP_002382237.1\|1050473_1050890_+	hypothetical protein	NA	NA	NA	NA
WP_002365550.1\|1050902_1051415_+\|tail	phage major tail protein, TP901-1 family	W6LP72	Streptococcus_phage	8.8e-35	49.4
WP_002357848.1\|1051447_1051807_+	hypothetical protein	A0A0F6N4J9	Staphylococcus_phage	7.6e-09	32.2
WP_002382238.1\|1051899_1052193_+	hypothetical protein	NA	NA	NA	NA
WP_002382239.1\|1052182_1055116_+	membrane protein	A0A1U9WR55	Streptococcus_virus	6.6e-10	25.3
WP_002365553.1\|1055117_1056044_+\|tail	phage tail family protein	C9E2K5	Enterococcus_phage	9.0e-147	78.6
WP_174776012.1\|1056056_1057514_+\|tail	phage tail protein	C9E2K6	Enterococcus_phage	1.6e-174	47.7
WP_002379376.1\|1057546_1059316_+	hypothetical protein	A0A097BYA8	Enterococcus_phage	1.5e-142	71.6
WP_002357842.1\|1059339_1059735_+\|holin	phage holin family protein	F0PIJ6	Enterococcus_phage	2.8e-33	48.9
WP_002382241.1\|1059853_1060978_+	SH3 domain-containing protein	A0A139ZVY1	Enterococcus_phage	3.2e-77	44.3

DBSCAN-SWA_3

1482245 : 1490889

Synechococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002364081.1\|1482245_1482818_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	9.2e-25	35.1
WP_174776021.1\|1482814_1483846_-	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3FGG1	Synechococcus_phage	1.1e-55	44.4
WP_002382407.1\|1483847_1485287_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	2.1e-49	33.0
WP_016633930.1\|1485262_1487482_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.3e-146	39.9
WP_002369271.1\|1487478_1488153_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_002357271.1\|1488153_1488405_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_002369269.1\|1488418_1489132_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3ELR0	Synechococcus_phage	5.7e-48	43.0
WP_002379523.1\|1489283_1490408_-	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_002365766.1\|1490400_1490889_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	6.4e-19	42.0

DBSCAN-SWA_4

2190318 : 2200059

Streptococcus_phage(57.14%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002385686.1\|2190318_2192502_+	anaerobic ribonucleoside-triphosphate reductase	A0A0C5KKX3	Enterococcus_phage	3.1e-286	66.8
WP_002356379.1\|2192534_2193131_+	anaerobic ribonucleoside-triphosphate reductase activating protein	A0A0C5K925	Enterococcus_phage	6.0e-51	56.4
WP_002362328.1\|2193175_2194294_-	DNA polymerase IV	NA	NA	NA	NA
WP_002356377.1\|2194419_2195178_-	iron export ABC transporter permease subunit FetB	NA	NA	NA	NA
WP_002356375.1\|2195161_2195824_-	ATP-binding cassette domain-containing protein	G3M9Y6	Bacillus_virus	6.7e-19	31.1
WP_002359438.1\|2195838_2196711_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	1.1e-80	57.2
WP_002356372.1\|2196823_2197171_-	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	8.1e-16	36.7
WP_002356371.1\|2197163_2198003_-	stage 0 sporulation family protein	NA	NA	NA	NA
WP_002389791.1\|2198119_2199070_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	6.2e-34	33.0
WP_002356367.1\|2199071_2199401_-	cyclic-di-AMP receptor	NA	NA	NA	NA
WP_002356366.1\|2199420_2200059_-	dTMP kinase	M1PSC7	Streptococcus_phage	2.1e-54	53.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP046113

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection