CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP053799	Vibrio cholerae strain SL5Y chromosome 2, complete sequence	1 crisprs	DEDDh,csa3,cas3	0	0	0	0
NZ_CP053798	Vibrio cholerae strain SL5Y chromosome 1, complete sequence	1 crisprs	cas3,DEDDh,DinG,csx1,csa3	0	1	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP053799_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053799_1

583750-583901

Orphan

Consensus_repeat	Method
TGCCCCTCCCCCTTTTAGGGGGAGGATGGGAGGGGGTATTTCACACCAGCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP053799_1

>merge|NZ_CP053799|1|583750-583901|CRISPRCasFinder
TGCCCCTCCCCCTTTTAGGGGGAGGATGGGAGGGGGTATTTCACACCAGCCTAACTAAACCGCATTCACTCTTTACGTTAGCAATAGCGAAAATGCTTCGTGCCCCTCCCCCTTTTAGGGGGAGGATGGGAGGGGGTATTTCACGCCAGCCT

>NZ_CP053799|1|1|583750-583901|CRISPRCasFinder
TGCCCCTCCCCCTTTTAGGGGGAGGATGGGAGGGGGTATTTCACACCAGCCT	AACTAAACCGCATTCACTCTTTACGTTAGCAATAGCGAAAATGCTTCG
TGCCCCTCCCCCTTTTAGGGGGAGGATGGGAGGGGGTATTTCACGCCAGCCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053799.1\|WP_175234033.1\|587742_588783_-\|AbrB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225721
NZ_CP053799.1\|WP_175234037.1\|592096_593038_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NZ_CP053799.1\|WP_000078373.1\|575900_576896_-\|sugar-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225263
NZ_CP053799.1\|WP_175234032.1\|583968_585357_-\|IS4-family-transposase	unknown	unknown	gnl\|CDD\|280446
NZ_CP053799.1\|WP_175234035.1\|590819_591170_-\|GlpM-family-protein	unknown	unknown	gnl\|CDD\|284382
NZ_CP053799.1\|WP_162298996.1\|573683_574442_+\|molybdopterin-synthase-adenylyltransferase-MoeB	unknown	unknown	gnl\|CDD\|180204
NZ_CP053799.1\|WP_000581562.1\|593034_593325_-\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|224278
NZ_CP053799.1\|WP_175234031.1\|580626_582879_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|273807
NZ_CP053799.1\|WP_094392259.1\|574985_575816_+\|sulfurtransferase	unknown	unknown	gnl\|CDD\|225450
NZ_CP053799.1\|WP_175234036.1\|591361_592087_+\|tRNA-(adenine(22)-N(1))-methyltransferase-TrmK	unknown	unknown	gnl\|CDD\|225258
NZ_CP053799.1\|WP_019827709.1\|586112_587375_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053799.1\|WP_019827715.1\|589782_590298_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|226489
NZ_CP053799.1\|WP_094392265.1\|571634_572288_-\|GTP-cyclohydrolase-I-FolE	unknown	unknown	gnl\|CDD\|236472
NZ_CP053799.1\|WP_019829607.1\|583194_583707_+\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|349971
NZ_CP053799.1\|WP_001080513.1\|578535_580530_+\|transketolase	unknown	unknown	gnl\|CDD\|183723
NZ_CP053799.1\|WP_094392261.1\|574595_574964_+\|glyoxalase	unknown	unknown	gnl\|CDD\|319944
NZ_CP053799.1\|WP_000066347.1\|577488_578439_+\|transaldolase	unknown	unknown	gnl\|CDD\|235381
NZ_CP053799.1\|WP_019827713.1\|588795_589767_-\|D-2-hydroxyacid-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|240646
NZ_CP053799.1\|WP_094392263.1\|572439_573675_+\|molybdopterin-molybdotransferase-MoeA	unknown	unknown	gnl\|CDD\|182643
NZ_CP053799.1\|WP_175234034.1\|590330_590780_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240047

Protein	Function_ID	Function_description	E-value
NZ_CP053799.1\|WP_175234033.1\|587742_588783_-\|AbrB-family-transcriptional-regulator	gnl\|CDD\|225721	COG3180, AbrB, Putative ammonia monooxygenase [General function prediction only].	9.7269e-79
NZ_CP053799.1\|WP_175234037.1\|592096_593038_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.19948e-73
NZ_CP053799.1\|WP_000078373.1\|575900_576896_-\|sugar-binding-transcriptional-regulator	gnl\|CDD\|225263	COG2390, DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription].	6.1728e-125
NZ_CP053799.1\|WP_175234032.1\|583968_585357_-\|IS4-family-transposase	gnl\|CDD\|280446	pfam02281, Dimer_Tnp_Tn5, Transposase Tn5 dimerization domain. Transposons are mobile DNA sequences capable of replication and insertion into the chromosome. Typically transposons code for the transposase enzyme, which catalyzes insertion, found between terminal inverted repeats. Tn5 has a unique method of self- regulation in which a truncated version of the transposase enzyme acts as an inhibitor. The catalytic domain of the Tn5 transposon is found in pfam01609. This domain mediates dimerization in the known structure.	2.16828e-14
NZ_CP053799.1\|WP_175234035.1\|590819_591170_-\|GlpM-family-protein	gnl\|CDD\|284382	pfam06942, GlpM, GlpM protein. This family consists of several bacterial GlpM membrane proteins. GlpM is a hydrophobic protein containing 109 amino acids. It is thought that GlpM may play a role in alginate biosynthesis in Pseudomonas aeruginosa.	6.22428e-49
NZ_CP053799.1\|WP_162298996.1\|573683_574442_+\|molybdopterin-synthase-adenylyltransferase-MoeB	gnl\|CDD\|180204	PRK05690, PRK05690, molybdopterin biosynthesis protein MoeB; Provisional.	2.20586e-167
NZ_CP053799.1\|WP_000581562.1\|593034_593325_-\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	5.07236e-26
NZ_CP053799.1\|WP_175234031.1\|580626_582879_-\|TonB-dependent-receptor	gnl\|CDD\|273807	TIGR01785, Heme/hemopexin_utilization_protein_C, TonB-dependent heme/hemoglobin receptor family protein. This model represents the TonB-dependent outer membrane heme/hemoglobin receptor/transporter found in bacteria which live in contact with animals (which contain hemoglobin or other heme-bearing globins) or legumes (which contain leghemoglobin). Some species having hits to this model such as Nostoc, Caulobacter and Chlorobium do not have an obvious source of hemoglobin-like proteins in their biological niche and so the possibility exists that they act on some other substance. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins].	2.02583e-44
NZ_CP053799.1\|WP_094392259.1\|574985_575816_+\|sulfurtransferase	gnl\|CDD\|225450	COG2897, SseA, Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism].	2.07597e-112
NZ_CP053799.1\|WP_175234036.1\|591361_592087_+\|tRNA-(adenine(22)-N(1))-methyltransferase-TrmK	gnl\|CDD\|225258	COG2384, COG2384, Predicted SAM-dependent methyltransferase [General function prediction only].	2.35606e-78
NZ_CP053799.1\|WP_019827715.1\|589782_590298_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|226489	COG3981, COG3981, Predicted acetyltransferase [General function prediction only].	4.42928e-79
NZ_CP053799.1\|WP_094392265.1\|571634_572288_-\|GTP-cyclohydrolase-I-FolE	gnl\|CDD\|236472	PRK09347, folE, GTP cyclohydrolase I; Provisional.	3.42887e-108
NZ_CP053799.1\|WP_019829607.1\|583194_583707_+\|RNA-methyltransferase	gnl\|CDD\|349971	cd18098, SpoU-like, SAM-dependent rRNA or tRNA methylase related to SpoU. RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.	1.19478e-70
NZ_CP053799.1\|WP_001080513.1\|578535_580530_+\|transketolase	gnl\|CDD\|183723	PRK12753, PRK12753, transketolase; Reviewed.	0
NZ_CP053799.1\|WP_094392261.1\|574595_574964_+\|glyoxalase	gnl\|CDD\|319944	cd08356, VOC_CChe_VCA0619_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. uncharacterized subfamily of vicinal oxygen chelate (VOC) family contains Vibrio cholerae VCA0619 and similar proteins. The VOC superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.84474e-64
NZ_CP053799.1\|WP_000066347.1\|577488_578439_+\|transaldolase	gnl\|CDD\|235381	PRK05269, PRK05269, transaldolase B; Provisional.	0
NZ_CP053799.1\|WP_019827713.1\|588795_589767_-\|D-2-hydroxyacid-dehydrogenase-family-protein	gnl\|CDD\|240646	cd12169, PGDH_like_1, Putative D-3-Phosphoglycerate Dehydrogenases. Phosphoglycerate dehydrogenases (PGDHs) catalyze the initial step in the biosynthesis of L-serine from D-3-phosphoglycerate. PGDHs come in 3 distinct structural forms, with this first group being related to 2-hydroxy acid dehydrogenases, sharing structural similarity to formate and glycerate dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily, which also include groups such as L-alanine dehydrogenase and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. Many, not all, members of this family are dimeric.	1.35399e-155
NZ_CP053799.1\|WP_094392263.1\|572439_573675_+\|molybdopterin-molybdotransferase-MoeA	gnl\|CDD\|182643	PRK10680, PRK10680, molybdopterin biosynthesis protein MoeA; Provisional.	0
NZ_CP053799.1\|WP_175234034.1\|590330_590780_-\|NUDIX-domain-containing-protein	gnl\|CDD\|240047	cd04691, Nudix_Hydrolase_32, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.68888e-42

>NZ_CP053799.1|WP_019829607.1|583194_583707_+|RNA-methyltransferase
MTTSSTVIIGLHNPKSPTNVGAVMRAAGCYNATQVRYNGTRYARAVKFQTDTQNSHERIGLVEMDDLTAGLDSEVKIVCVELAVGATALPHFTHPEQAIYLFGPEDGSLPQEVVDQAHHVVYVPTHGCMNLAATVNVVLYDRLAKSLGEIDNQAQVIANRDNKNRLKVKS
>NZ_CP053799.1|WP_175234031.1|580626_582879_-|TonB-dependent-receptor
MQLKPLFTLLPVVLSSVVQAQENTEQAVDETVTVHGQSIPTDQRTRSDLDKVRGIANADIFSGITSVQSNNMHNEAGALDIGIRGVQGEGRVPIFIDGSLQSTHTSRGYQGVSDRTYIDTDLLSSLTVNKGATIESSPYASGAVGGVVNATTLGIKDIIKDDQAFGVVLKARANNHNRTPDVSSDYSEQGQYALDERGEHSAFKHGSLMLGLGYQAESFNTVLAYSKRSKGNHFAGKKGYEEYQEPVVGQGQEVVNTSFESDSWLFKLASDTGTAHNADFNYRHHAQKAGEVLMAYWYKSSEDWEGNPYPDGKDRMPQWGLGTAKVNTYSANYYYQPDHPWLHLNANFWYTEADLAQYNGLWALGTNAEQYFHAYHNDRSGLSLTNETLLTQWPVRLNYGLAQQNERLSPEEDGQTRFTKTVTSRHGKRTAQNLFANADIDYSPLRVQLGLNLHNAKSTDYQTKQQLDYKEKLDLLSEFTYALTPSTQLFLKSSRTYRMPSLYETTLSNEVFSYNPYNPIKPEQAWNNEVGVQFMASNSVLQDDRLNLSVSYFRNSIKDFISGGRLAKTPGMSEWQANFTFTNYDKLQLSGWELGAHYQYAWLYTHFAATLYSETKICSVQQAQYAESDTCNSLGFAWGLTPTRIPPKQNLYLNVGTKFFNDTLDSGVKVSYHSGKSNPSDWLAGTAANPILEIPSDYTIDLYSQYELNANTQLFFAINNVTDRYQVRPGSVVSMPDPGRTITLGFEISY
>NZ_CP053799.1|WP_001080513.1|578535_580530_+|transketolase
MNRKQLANAIRALSMDGVQKANSGHPGAPMGMADIAEVLWRSHLNHNPQNPNWADRDRFVLSNGHGSMLIYSLLHLSGYELSIDDLKNFRQLHSKTPGHPEYGYAPGIETTTGPLGQGITNAVGMAIAEKALAAQFNKPGHDIVDHFTYVFMGDGCLMEGISHEACSLAGTLGLGKLIAFWDDNGISIDGHVEGWFSDDTPKRFEAYGWHVIPAVDGHDADAINAAIEAAKAETSRPTLICTKTIIGFGSPNKAGSHDCHGAPLGNDEIKAAREFLGWEYAPFEIPADIYAAWDAKQAGASKEAAWDEKFAAYAKAYPAEAAEYKRRVAGELPANWEAATSEIIANLQANPANIASRKASQNALEAFGKLLPEFMGGSADLAPSNLTMWSGSKSLTAEDFSGNYIHYGVREFGMTAIINGIALHGGFVPYGATFLMFMEYARNAMRMAALMKVQNIQVYTHDSIGLGEDGPTHQPVEQIASLRMTPNMSTWRPCDQVESAVAWKLAIERKDAPSALIFSRQNLAQQPRSAEQVANIAKGGYILKDCAGQPELILIATGSEVELAVAAYEQLSAEGKAVRVVSMPSTDAFDKQDAAYREAVLPAAVTKRIAIEAGIADFWYKYVGFGGRIIGMTSFGESAPAGELFKLFGFTTENVVKQAKELLA
>NZ_CP053799.1|WP_000066347.1|577488_578439_+|transaldolase
MSNKLAQLRKLTTVVADTGEIDAIKKYQPEDATTNPSLILKAAQIAEYAPLIDQAIAYAKTQSNDKAQQVQDTCDMLAVNIGKEILKTIPGRISTEVDARLSYDTERSVAKARQLVKMYNDAGISNDRILIKLASTWEGIRAAEILEKEGINCNLTLLFSFAQARACAEAGVFLISPFVGRIMDWYKAKEGRDFAASEDPGVLSVTKIYNYYKEHGYKTVVMGASFRNIGEILELAGCDRLTIAPSLLAELEAAEGELVAKLVDSKGSKARPAPMTHSEFLWEHNLDAMAVEKLAEGIRNFAVDQGKLEAMIAAKL
>NZ_CP053799.1|WP_000078373.1|575900_576896_-|sugar-binding-transcriptional-regulator
MSQIPEISVESTDLLTEIAVSYYQDGATQEEISKKYTISRAKVGRLLKQARDEGIVEITVKYHPVFSAKIEQRLIERFGVRRALIALDQPNDEAQRQQVAGLVSNYLTSTLKNGMVVTVGQGRNVSAVAHHVGVITPRDCKFVCSIGGIHPRGGMFNADHICRQLAKKYGGSSETLYAPAYAENPEQKRVFMQNSTVKQTLDLARKADIALVGIGDMSENSYMVDLGWFTPEEVVQSRLNQGVVGDFAGHDFFDVHGRIANTVMNDRVIGLGIDEFRPIAEVIAIAAENSKPLALLGALRTGAIDVIATSVSNALTVLNLDEQMQTALSAS
>NZ_CP053799.1|WP_094392259.1|574985_575816_+|sulfurtransferase
MTSPLVTAQWLQQHLHDPNLVILDSSIEFQIPTESEKDWVNKIPNSQRFDYDKVFCDPDSPLPHMMPSEERFNTLARKLGINQDSFIVVYDNSGTFASPRAWWMFKAMGHHKVYILNGGLTEWKAQGYNVTQNYREPTAKGNFDGKLNPQAFVDASYVHKQIANPHSQTIDARGLARFFGEVPEPRPGVRCGHIPGSSCLPFAELIDGHKLKEEAELRPLLTHMLPETAQEYLFSCGSGVTACIVLLAAYVCGYQNLSVYDGSWTEWGQRQDLPIE
>NZ_CP053799.1|WP_094392261.1|574595_574964_+|glyoxalase
MPNLDVLEIKSFVPAQDFTASKQFYLSIGFEVVSEFGDVAYLRLGKCAFLLQNIHQRPHQGNTMMHLLVEDAQSWFDHVKTLQLEERFESKVTDLITQPWGMLEFCLVDPSDVLWRIGQRIE
>NZ_CP053799.1|WP_162298996.1|573683_574442_+|molybdopterin-synthase-adenylyltransferase-MoeB
MDILSDTEMLRYNRQIILKAFDFEGQEKLKQSSILILGAGGLGCASSQYLATAGVGHITLIDDDVVELSNLQRQVLHHDADIGRAKVDSAADSLRLLNPHLNVETIQARLSDDELDVLIARHDLVLDACDNVDTRNQLNRLCFKHKTPLVSGAAIRMEGQVSVFTYQDPAQPCYQCLSALFGSSALSCVEAGVMAPVVGIIGAVQAMEAIKVLTGLGTPKQGKILILDAMSMSWREMNLMQLPQCPVCHTSE
>NZ_CP053799.1|WP_094392263.1|572439_573675_+|molybdopterin-molybdotransferase-MoeA
MGCCDAPGLMPIEDALEKMLSRIKPVESTLRLPLPEALGYVLAEAILSPIHVPPFDNSAMDGYAVRRAELAQQKPLPVAGKSFAGQPFTAEWPPMTCVRIMTGAQIPAGCDAVIMQEQATITEEGVVFCQHEVKPNDNIRPTGDDIRQNDVVLERGARLTARDIPMIATLGISHVTVYRKPKVAFFSTGDELKPLGEPLQAGQIYDSNRYGIKPLIENFGCEAIDLGIVPDCPATLKATFEQAQSLADVVVTSGGVSVGEADYTKDILEELGEIGFWKLAIKPGKPFAFGALQNAWFCGLPGNPVSAVLTMYVLVQPMLAKLAGHSAWQAPESIPAITRSPFKKAPGRTDFQRGIYRIENGQFVVESTGNQSSGAFRSMSLANCFVVLERERGRVEVGETVQIQLFNPTLY
>NZ_CP053799.1|WP_094392265.1|571634_572288_-|GTP-cyclohydrolase-I-FolE
MSGLSESAKLVKDALERRGLETPMQPNLATPAEKKEKIEQHMREILNLLGLDLTDDSLEETPQRIAKMYVDEIFSGLDYDNFPKITVIENKMKVSEMVKVKDITLTSTCEHHLVTIDGTAAVAYIPRGKIIGLSKINRIVRFFAQRPQVQERMTQQILVALQTLLESDDVAVTIDATHYCVKSRGVMDATSVTTTTALGGIFKSNPATRAEFLHGLR
>NZ_CP053799.1|WP_175234032.1|583968_585357_-|IS4-family-transposase
MTYIEPTLWAQKQFGQAHLNDPRRTQRLVALAASLAEQPGVPVSKLIISPADMEGDYRFIRNEQIKAEDIAEAGFHVTAQEALEQQTLLALEDTTSLSYSHRSIQDELGHSNQGNRNRAMFIHSTLLFAPETQVVVGLIEQQRWTRDIEKRGQGHQYATRPYKEKESYKWEQASRHVAERLGDKISDVISVCDREADLFEYLTYKQEQQQRFLVRSMQSRCIKEHDNRLYDYASKLQSAGERVLDIPQKGGRKARTVHLYIKYAPVTLKSPATKKEFNNIPLYYVGCIEQGESNDKLAWHLLTSEPITSKEEALKIVSYYELRWLIEDFHKVWKSEGTQVEQLRMQSKDNLERLSVILAFIATRLLQLRFMNESDELSKSSCEPILKGKAWKLMWLKLERKGLPKEAPDISWAYRGIARLGGWKNTKRTGRASIKTLWQGWFRLQTILEGYELAKSLDSPDL
>NZ_CP053799.1|WP_019827709.1|586112_587375_-|hypothetical-protein
MKKHRASRVFVPGGMPELTYIERAESSIKESLNKAQDNLCKLVTLTGQTKSGKTVLTQRVFPEFEDHNIWINGGSIQSENDIWEQVLDALDGWTNTEVTDTDGSASALKSSGKGKGSVGFASIDAQIGAERTESSSSSSKSSRAMSSKSAALRALRESGCALIIDDFHYFERDLQGKFVRAVKPLVFHGLPVILIAIPHRRYDAIKVEREITGRIENVTMPYWEKDELKQIPETGFPLLNVTTSLEVVDKLAEESMGSPHLMQEFCRQLCLAHNVEETLDEPLFIGDFEDSLFKSVGESTGKIIFDKLSTGPRQRSDRLQRTLTNNEQVDIYKVVLLALARLKPEMQTVTYEELRTAIREILKDSVPQAHEVTRVLEKMSEIASSDEASTPVIDWEKDEQKLHITDPFFAFYLKWGAPQV
>NZ_CP053799.1|WP_175234033.1|587742_588783_-|AbrB-family-transcriptional-regulator
MFERVSFTLFIQILLVAAVSAGAGTLLSIPLSEMFIASGLVIVLHKKRWLTIHTPPWLLLFVQVVLGISVGATISLSELGTTLTFPVIVGLVCCLTLQIISSYLWLTKKEGWTPFESLLGAVPGAMAAILVISESSEKPSAKVVYSHSVRLMILTLLALLISNSAPDSASVDGSLTVYAWLIFLALALMSLLLGKASTLLGIPAPYMLAALLITASFNGFATGIDMQLPKWMVIFTTALLGILIGSRIADTTLREAMAYSRAGVMVTMIGLLVAVGVSGVFSILIDKSWIVLLLSWVPGSVEAMTAVALLLGMEPAFVMINHALRLLLLYSLPAMLKKQLEELRGR
>NZ_CP053799.1|WP_019827713.1|588795_589767_-|D-2-hydroxyacid-dehydrogenase-family-protein
MKIAILDDYQNVVRGLNAFQCLQGHDVTVFNDSLSDETVLIERLKPFEALVLIRERTTITENLLAHLPNLKLISQTGKVSNHIDVPLCERYGVTVLEGIGSPVAPAELCWSLILAASRHLPSYIEQLHAGHWQQNGGLGLGRTLSGRTLGIWGLGKIGQRIAQFGHVFGMPVLVWGSEASRQKALELGYQAAADKAEFFAKADVLSLHLRLNDATRGIVTKQDLLAMKPDSLFVNTSRAELVESGALYSVMQANPTRQAAVDVYENEPALPNNEPLLSLPNVLCAPHLGYVEKNSYEIYFQAAFENVVKFAHSAAKTSLSDKA
>NZ_CP053799.1|WP_019827715.1|589782_590298_-|GNAT-family-N-acetyltransferase
MPLTRLTLQDEAAFAEFFQDFQRHDPINCDFYRQGDENFADYVQLLDDHAHGQNLPCGYVPCSYFWYQDQQGKILGALRLRHHIDTPFLTNEAGHIGYDVAPSARRKGIGREMLRLGLIEAKRLGLKRVLLVADSDNHASRRVIESNGGVFESTINGEYFPSLLARYWIDL
>NZ_CP053799.1|WP_175234034.1|590330_590780_-|NUDIX-domain-containing-protein
MFVEKTEPVEKTPTRLPVAECVSFLLIKEGSCLLERRSATKASDPNIIAIPGGHIEAGENQAQALLREVQEELGVDATRSVYLCSLYHPTEFELQLLHYYVVDQWQGEIACHEADEVFWTPIAPSVVETIADKIAIEEFQRLYPRYLAL
>NZ_CP053799.1|WP_175234035.1|590819_591170_-|GlpM-family-protein
MAALFFKCLLGALAVLIIALLSKTKSFFISGLVPLFPTFALIAHYIVGTERTMEDLRTTALFGLYSLIPYAAYLLAVYYLSYRLSLTGTLVCATLVWLVFAALLLVGWTRLHPSMA
>NZ_CP053799.1|WP_175234036.1|591361_592087_+|tRNA-(adenine(22)-N(1))-methyltransferase-TrmK
MKLGKRLTQLVKHVKRDYDHIWDCCCDHGLLGATLLKQHPSSTVHFVDIVPSLIEKVTLDLTRYFPATTDSPRWRTYCLDVRDLPLEANAGSHLVIIAGVGGDLMTEFIAELAKRHPSMTFDLLLCPVHHTYTLREQLIALNAELKSERLVEENQRIYELLHVQILPSSGACSHPLSLVGESLWQVSGPDQSKIAQRYLQQLQQHYQRKAQGGDAGAEQRWQAYQAVEILQSMDSTLELAQ
>NZ_CP053799.1|WP_175234037.1|592096_593038_+|LysR-family-transcriptional-regulator
MKALNDLNLFVETARQGSFSKAANSLSLTTAAVSAAIRRLEEQVQFPLFVRSTRHIRLTHEGEIFLAKTQTALATLQEGLDQIACARGQLAGQLHISAPSDLGRNLLLDWIDAFIALHPNVTVKLDLSDRLTDMYANPVDIAIRYGQPADSNLVAMLLCDSNERVLCASPEYLAAHPPILHPDDLQHHNCLCFMLADTLHNKWILSRNGETHSVVVQGNPACNDGEVVHRLAVKGKGIANKSLMDISQDIIDGRLVRILPEWESGPVPIYMVCADRRLITPTIRAFQEFIREKGCQQRRAVLTAIQEREQNPR
>NZ_CP053799.1|WP_000581562.1|593034_593325_-|antibiotic-biosynthesis-monooxygenase
MIHLLAEIKAFPDSAQQVQALLEALLEPSRNEEGCCQYELYRDNSIEGLFLMQEIWCSEESLQKHQQSAHFQHFQQKIGEREMLEYLQLRPLTFVG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP053798_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053798_1

2571225-2571468

Orphan

Consensus_repeat	Method
AAAATGTGCCTCCTTAGCTCAGTCGGTAGAGCAACGGACTGATAATCCG	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP053798_1

>merge|NZ_CP053798|1|2571225-2571468|PILER-CR
TGTGCCGGCTTAGCTCAGTAGGTAGAGCAACTGACTTGTAATCAGTAGGTCGCCAGTTCGATTCCGGCAGCCGGCACCACTTAAAATTTGCCTCGATAGCTCAGTCGGTAGAGCAGAGGATTGAAAATCCTCGTGTCGGTGGTTCGATTCCGCCTCGAGGCACCACTATTAAAAGTTGTGCCATAGACACAATAAAAATTGTTCCTCCTTAGCTCAGTCGGTAGAGCGACGGACTGTTAATCCG

>NZ_CP053798|1|1|2571225-2571468|PILER-CR
TGTGCCGGCTTAGCTCAGTAGGTAGAGCAACTGACTTGTAATCAGTAGG	TCGCCAGTTCGATTCCGGCAGCCGGCACCACTTAAAA
TTTGCCTCGATAGCTCAGTCGGTAGAGCAGAGGATTGAAAATCCTCGTG	TCGGTGGTTCGATTCCGCCTCGAGGCACCACTATTAAAAGTTGTGCCATAGACACAATAAAAAT
TGTTCCTCCTTAGCTCAGTCGGTAGAGCGACGGACTGTTAATCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053798.1\|WP_094392753.1\|2564090_2564522_+\|DUF4426-domain-containing-protein	unknown	unknown	gnl\|CDD\|379616
NZ_CP053798.1\|WP_094392755.1\|2566427_2567348_-\|glutaminase-B	unknown	unknown	gnl\|CDD\|234880
NZ_CP053798.1\|WP_001087261.1\|2563198_2563756_+\|YggT-family-protein	unknown	unknown	gnl\|CDD\|223833
NZ_CP053798.1\|WP_001914289.1\|2563755_2564046_+\|YggU-family-protein	unknown	unknown	gnl\|CDD\|179931
NZ_CP053798.1\|WP_053034672.1\|2582374_2582872_-\|type-3-dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|365932
NZ_CP053798.1\|WP_000546924.1\|2574429_2575284_-\|co-chaperone-DjlA	unknown	unknown	gnl\|CDD\|236512
NZ_CP053798.1\|WP_001243262.1\|2580137_2580953_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	unknown	unknown	gnl\|CDD\|234708
NZ_CP053798.1\|WP_094392754.1\|2565187_2566363_+\|radical-SAM-family-heme-chaperone-HemW	unknown	unknown	gnl\|CDD\|235550
NZ_CP053798.1\|WP_000780521.1\|2577846_2579142_+\|peptidylprolyl-isomerase-SurA	unknown	unknown	gnl\|CDD\|236758
NZ_CP053798.1\|WP_000383338.1\|2581024_2581405_+\|Co2+/Mg2+-efflux-protein-ApaG	unknown	unknown	gnl\|CDD\|180098
NZ_CP053798.1\|WP_057550627.1\|2581415_2582225_+\|symmetrical-bis(5'-nucleosyl)-tetraphosphatase	unknown	unknown	gnl\|CDD\|234673
NZ_CP053798.1\|WP_094392757.1\|2569866_2570994_+\|membrane-bound-lytic-murein-transglycosylase-MltC	unknown	unknown	gnl\|CDD\|183271
NZ_CP053798.1\|WP_000725016.1\|2564591_2565194_+\|XTP/dITP-diphosphatase	unknown	unknown	gnl\|CDD\|234648
NZ_CP053798.1\|WP_000095776.1\|2579131_2580124_+\|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA	unknown	unknown	gnl\|CDD\|234696
NZ_CP053798.1\|WP_000124738.1\|2569492_2569765_+\|oxidative-damage-protection-protein	unknown	unknown	gnl\|CDD\|180059
NZ_CP053798.1\|WP_162813836.1\|2582884_2583358_-\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|182143
NZ_CP053798.1\|WP_000005583.1\|2567458_2568178_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NZ_CP053798.1\|WP_094392756.1\|2568417_2569479_+\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|182805
NZ_CP053798.1\|WP_000769919.1\|2571757_2573383_+\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910
NZ_CP053798.1\|WP_071180988.1\|2575442_2577794_+\|LPS-assembly-protein-LptD	unknown	unknown	gnl\|CDD\|235158

Protein	Function_ID	Function_description	E-value
NZ_CP053798.1\|WP_094392753.1\|2564090_2564522_+\|DUF4426-domain-containing-protein	gnl\|CDD\|379616	pfam14467, DUF4426, Domain of unknown function (DUF4426). Members of this entry are found mostly in g-proteobacteria, especially in Vibrio. Strangely enough, there seems to be one eukaryotic homolog in Nematostella vectensis (NEMVEDRAFT_v1g226006), where the PA0388-like domain is fused with a domain homogous to the Methionine biosynthesis protein MetW (see below). In several Pseudomonas species, but also in Vibrio vulnificus and Azotobacter vinelandii PA0388 homologs are genomic neighbors of Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) and Methionine biosynthesis protein MetW. On the other hand, in most Vibrio species it appears as a part of a conserved operon involved in possible response to stress.	9.01056e-67
NZ_CP053798.1\|WP_094392755.1\|2566427_2567348_-\|glutaminase-B	gnl\|CDD\|234880	PRK00971, PRK00971, glutaminase; Provisional.	0
NZ_CP053798.1\|WP_001087261.1\|2563198_2563756_+\|YggT-family-protein	gnl\|CDD\|223833	COG0762, COG0762, Predicted integral membrane protein [Function unknown].	2.77868e-12
NZ_CP053798.1\|WP_001914289.1\|2563755_2564046_+\|YggU-family-protein	gnl\|CDD\|179931	PRK05090, PRK05090, hypothetical protein; Validated.	3.24897e-60
NZ_CP053798.1\|WP_053034672.1\|2582374_2582872_-\|type-3-dihydrofolate-reductase	gnl\|CDD\|365932	pfam00186, DHFR_1, Dihydrofolate reductase.	1.20946e-92
NZ_CP053798.1\|WP_000546924.1\|2574429_2575284_-\|co-chaperone-DjlA	gnl\|CDD\|236512	PRK09430, djlA, co-chaperone DjlA.	1.60415e-153
NZ_CP053798.1\|WP_001243262.1\|2580137_2580953_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	gnl\|CDD\|234708	PRK00274, ksgA, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA.	3.27746e-146
NZ_CP053798.1\|WP_094392754.1\|2565187_2566363_+\|radical-SAM-family-heme-chaperone-HemW	gnl\|CDD\|235550	PRK05660, PRK05660, radical SAM family heme chaperone HemW.	0
NZ_CP053798.1\|WP_000780521.1\|2577846_2579142_+\|peptidylprolyl-isomerase-SurA	gnl\|CDD\|236758	PRK10770, PRK10770, peptidyl-prolyl cis-trans isomerase SurA; Provisional.	9.14533e-157
NZ_CP053798.1\|WP_000383338.1\|2581024_2581405_+\|Co2+/Mg2+-efflux-protein-ApaG	gnl\|CDD\|180098	PRK05461, apaG, CO2+/MG2+ efflux protein ApaG; Reviewed.	1.16069e-74
NZ_CP053798.1\|WP_057550627.1\|2581415_2582225_+\|symmetrical-bis(5'-nucleosyl)-tetraphosphatase	gnl\|CDD\|234673	PRK00166, apaH, symmetrical bis(5'-nucleosyl)-tetraphosphatase.	1.18944e-168
NZ_CP053798.1\|WP_094392757.1\|2569866_2570994_+\|membrane-bound-lytic-murein-transglycosylase-MltC	gnl\|CDD\|183271	PRK11671, mltC, membrane-bound lytic murein transglycosylase MltC.	4.30209e-156
NZ_CP053798.1\|WP_000725016.1\|2564591_2565194_+\|XTP/dITP-diphosphatase	gnl\|CDD\|234648	PRK00120, PRK00120, dITP/XTP pyrophosphatase; Reviewed.	3.35577e-127
NZ_CP053798.1\|WP_000095776.1\|2579131_2580124_+\|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA	gnl\|CDD\|234696	PRK00232, pdxA, 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed.	0
NZ_CP053798.1\|WP_000124738.1\|2569492_2569765_+\|oxidative-damage-protection-protein	gnl\|CDD\|180059	PRK05408, PRK05408, oxidative damage protection protein; Provisional.	5.47988e-59
NZ_CP053798.1\|WP_162813836.1\|2582884_2583358_-\|threonine/serine-exporter-family-protein	gnl\|CDD\|182143	PRK09917, PRK09917, threonine/serine exporter.	3.91113e-67
NZ_CP053798.1\|WP_000005583.1\|2567458_2568178_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	6.44859e-111
NZ_CP053798.1\|WP_094392756.1\|2568417_2569479_+\|A/G-specific-adenine-glycosylase	gnl\|CDD\|182805	PRK10880, PRK10880, adenine DNA glycosylase.	0
NZ_CP053798.1\|WP_000769919.1\|2571757_2573383_+\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	5.89207e-58
NZ_CP053798.1\|WP_071180988.1\|2575442_2577794_+\|LPS-assembly-protein-LptD	gnl\|CDD\|235158	PRK03761, PRK03761, LPS assembly outer membrane complex protein LptD; Provisional.	0

>NZ_CP053798.1|WP_094392757.1|2569866_2570994_+|membrane-bound-lytic-murein-transglycosylase-MltC
MRKLVLCITTLLLSGCSREFIEKIYDVDYEPTNRFAKNLAELPGQFQKDTAALDALINSFSGNIEKRWGRRELKIAGKNNYVKYIDNYLSRSEVNFTEGRIIVETVSPIDPKAHLRNAIITTLLTPDDPAHVDLFSSKDIELKGQPFLYQQVLDQDGQPIQWSWRANRYADYLIANHLKVKQVDFKKAYYVEIPMVKDQIDIRGYKYASIVRKASRKYDIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAGRDVFKLVKNRSGEPSPEYLFNPENNIDTGTAYFYILKNRYLKEVRHPTSLEYSMISAYNGGTGGVLSTFSSDRQRAMRDLNALQPNQVYWALTKKHPNAEARRYLEKVTKFKKEFNAG
>NZ_CP053798.1|WP_000124738.1|2569492_2569765_+|oxidative-damage-protection-protein
MARTVFCTRLQKEADGLDFQLYPGELGKRIFDNICKEAWAQWQTKQTMLINEKKLNMMDPEHRKLLEQEMVNFLFEGKEVHIEGYTPPAK
>NZ_CP053798.1|WP_094392756.1|2568417_2569479_+|A/G-specific-adenine-glycosylase
MTPFAQAILTWYDAYGRKNLPWQQNKNAYRVWLSEIMLQQTQVATVIPYFERFLERFPTVHALAAAPQDEVLHFWTGLGYYARARNLHKAAQMVVSEYGGEFPTDLEQMNALPGVGRSTAAAVLSSVYKKPHAILDGNVKRTLARCFAVEGWPGQKSVENQLWHYAEMHTPSVDVDKYNQAMMDMGAMICTRSKPKCSLCPVESFCLAKQQGNPQEYPGKKPKTDKPVKATWFVMLYHDNAVWLEQRPQSGIWGGLYCFPQSEIANIQTTIDQRAIGDSTITSQKTLIAFRHTFSHYHLDITPILLQLSRKPDIVMEGSKGLWYNLSQPHEIGLAAPVKQLLHSLPFDIDSHI
>NZ_CP053798.1|WP_000005583.1|2567458_2568178_-|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MSEVITQEYTEDGKVLRRIRSFVRREGRLTKGQEAAMKECWPTMGIDYQPELLDWQQVFGNDNPVVLEIGFGMGASLVEMAKNAPEKNFLGIEVHSPGVGACLASAREAGVTNLRVMCHDAVEVFAHMIPDNSLHTLQLFFPDPWHKKRHHKRRIVQLEFAEMVRQKLIIGSGVFHMATDWENYAEHMVEVMNQAPGFANLATDGDYIPRPDERPLTKFEQRGHRLGHGVWDIKYQRTA
>NZ_CP053798.1|WP_094392755.1|2566427_2567348_-|glutaminase-B
MKPTAEILASIIEEVRPLTSKGNVADYIPALAKVPSEKLGIAVFTNQGEVITAGDAQEGFSIQSISKVLSLTLAMGLYQPDELWSRVGKEPSGQAFNSLIQLEMEQGIPRNPFINAGAIVVCDMLQSRLSAPRQRLLEFVRQLSGEPQIAYDKVVAASEMMHSDRNAAIAYLMRSFGNFHNEVIPVLHNYFHACALKMSCVELAKTFSYLANKGVSVVTGETVITPTQSKQTNALLATCGLYDGAGEFAYRVGMPGKSGVGGGIIAVVPGEMTIAVWSPALDQSGNSLAGTRALELLAQRIGRSIF
>NZ_CP053798.1|WP_094392754.1|2565187_2566363_+|radical-SAM-family-heme-chaperone-HemW
MLTPPPLSLYIHIPWCVQKCPYCDFNSHAQKGEIPEQEYLDALLQDLDRDIERYQLKGDPRLLHSIFIGGGTPSLISAEGIARLLQGVAERIAFKPEIEITMEANPGTIEAQRFAGYRTAGVTRISIGVQSFEPEKLARLGRIHGQQEAVRAAQLAHQIGLNSFNLDLMHGLPDQTPEQALADLDQAIALNPPHLSWYQLTIEPNTLFYSKPPKLPDEDALWDIFELGHQKLSDAGYVQYEISGYSKLGYQCQHNLNYWRFGDYLGIGCGAHGKLSFADGRIVRTTKTKHPRGYLAALNNLAKAYLDSEQLVADQDKPFEFFMNRFRLIEPCPKADFTATTGLTIDVIRPTLDWALSEGYLSEDDQHWQITEKGKLFLNDLLEAFMADEEE
>NZ_CP053798.1|WP_000725016.1|2564591_2565194_+|XTP/dITP-diphosphatase
MKKIVLATGNQGKVREMADLLSDFGFDVVAQSEFNVPEAAETGTTFIENAIIKARHAAQITGLPAIADDSGLEVDYLNGAPGIYSARYAGEHASDGDNLNKLLVAMQDVPDDQRSARFHCVLVLMRHADDPTPIVCHGKWEGKILTAPHGSNGFGYDPIFWVPEENCASAELEPVRKKQLSHRGKALQKLFKAIEEQRTC
>NZ_CP053798.1|WP_094392753.1|2564090_2564522_+|DUF4426-domain-containing-protein
MREWMMSLLLTLLALPASAEQQKTIKDIEVHYSAFNSTFLTPKVASSYQLTRNGYTAILNISVLDRASLGKPATEAKLTGHAKNLIGNLRELSFKQVKEGNAIYYLAEVPISNEEMLTFDIDVDAGLKGAGKLTFSQKFYTEQ
>NZ_CP053798.1|WP_001914289.1|2563755_2564046_+|YggU-family-protein
MAAVWREGDDLLLRLYIQPKASRDSIIGLHGEELKVAITAPPIDGKANAHLSKYLAKLCKVAKGSVVIEKGELGRHKQVRILQPSQIPAEIAALIE
>NZ_CP053798.1|WP_001087261.1|2563198_2563756_+|YggT-family-protein
MNSLSFLINTLFDLYIMVVILRIWLQAARADFYNPFSQFIVKATQPVVGPLRRVIPSIGSIDLATIVFAYVLCVLKFMALVLIASSGSVSFSADFLFLGLLSLIKAAGGLLFWVLLIRAILSWVSQGRSPIEYVFHQLTEPMLAPIRRIIPVMGGFDLSILVLFIVLQFANFLMGDVIGPIWYQL
>NZ_CP053798.1|WP_000769919.1|2571757_2573383_+|methyl-accepting-chemotaxis-protein
MKLKTQAYLLSAIILAALLALTATGLWTLRVASNLDNKARVTELFNSAYSILTEVEKLAQEGKMSEPEAKALATRLMRNNLYKDNEYVYVADENMTFVATPLDPQLHDTSFHDFKDGKGNSVGRLIQDVLRHQSGKLVEYTWTQKQADGSIEEKLSIARKTPHWGWVVGTGIGFNEVNARFWSTAQWQLSLCVVIAVAILSLLLVAIRKILLIIGGEPNEVRSAVQAVAQGRIRREFAIQAPKESIYGAVQQMSSSLADLVAKLEQSMVALRSELAGAGTRAKSIAELTDSQQQSTAMIATAMTEMASSANQVADSARDTAFNTDQADQQSQHTQKLIHNTVSNIQGLATQLQTASTAVAELDLDVKNIAKVLDVIGDIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRNLAGRTQTSTKEIQQMIHNLQEGSRNAIQTIQICGQTSQSSVQESENAASALALIVSALESVSSMSHQIATAAAEQTQVSDDIARRINMIEESGSKLSRVVMESHNSTQTLTKLARELEQWAAHFEVTR
>NZ_CP053798.1|WP_000546924.1|2574429_2575284_-|co-chaperone-DjlA
MHIFGKILGAFFGFLFGGPFGAIFGIFLGHQFDKARRLNQAGFQSGTFGAGPSQAERQEEFFKSAFSVMGHVAKAKGQVTKEEIQLATIMMDRMNLTLEQKRAAQDAFRDGKESDFPLEQVLERVKIATGGRFDLLQFFLELQVSSAFADGDVHPSERQVLHRIARGLGFSSEQLERRLRMQEAAFRFQQGGGFGGSQQQSHSGQQWQQPSSRHQLADAYEVLGVSESASAQEVKRAYRKLMNEHHPDKLMAKGLPPEMMNVAKEKSQQIQHAYELIRKEKGIK
>NZ_CP053798.1|WP_071180988.1|2575442_2577794_+|LPS-assembly-protein-LptD
MSCFSRTFLAASISAALFAPQIQAEASVDDNRAQLPNGEQCLVNQPEPTNPGQQPINVEADKLEAINGQKATYSGNVVVVQGKKRIAADNVTLHQQENVVVAEGNVQFSDGEIKTHSTKATNHLNTDEMTLENTRYQFLCEPGRGEAVYVSKTGKAVYEIEDGSITSCPDGDNAWRMRASSIDVDQNEEIATFYNPRLEVQNVPVFYLPYLTVPIGDTRKTGFLYPTASYGSRNGYSFEVPIYWNLAPQYDLETTFNYMQKRGTQLNSVFRYLTDFGAGQIKSEYLADDQLHTELGDRWAFQYEHNGIFQQAWKFEIDYSKVSDINYFSDLDSGVGNREDGQLIQEGRATYRSDSWDSALLVRDFQLLTKDTTSTNLPYRLMPQLSYNYYAPETMKYLDLDLVSHVSRFETDARGKPSATRVHIEPGLKIPFSNTWGNWTTEARVLGTYYQQDLDKTTDAKLEESVTRVIPEIRSVAGIVLERDTVLLDDYTQTLEPKIQYLYVPEKYQDNIGLYDSTLLQTDYYGLFRSRKYSGVDRIESANQVSYGASTRFFDSNYKERLNIAFGQIFYLDSKLNPSNKNPDSTSDKTSYSAWAVEMDFNFADYLFYHGGIQYDIDSQAVQLGNSTLEYRVASGYIQANYRYVAKDYIRNTVGDSITNIDDITRDGISQAGILAGYQLSRKWSASGQYYYDLTTDEALEWLANLTYTSDCWYVGFTYSNQLKSWNGNFVTDPYATPIYENNFSFNIGIIGFGTSIGAGSSMTGVDSAGNSLGYGRPFFLNN
>NZ_CP053798.1|WP_000780521.1|2577846_2579142_+|peptidylprolyl-isomerase-SurA
MKLWKPTLISVLSALTLFNAHAEPKQLDSVAVIVNSGVILQSDVDSALKTIKANAKQNKQPLPQETVLREQVLEKLIIDTLQQQEADRIGVKIDDNRLNEAIKEIAKNNQQTQEQLIASVAQEGLTYPEFREQVRKEMAASDARNALVRRRINILPAEVDTLAELLAQETDATVQYKISHIQLRVDDGQDKSAAETLANKLVNDLKNGADFAQMAYAYSKGPKALQGGDWGWMRKEEMPTIFADQIKMQNKGSIIGPFRSGVGFHILKIDDVKGLETVAVTEVNARHILIKPTIILSDEGAQKQLNEFVQRIKNGEVTFAELAQQYSQDPGSAAQKGELGYQTPDLYVPEFKHQIETLPVGQISEPFKTVHGWHIVEVLDRREVDRTDSALKNKAYRILFNRKFNEEASAWLQELRASAFVEVLKDEKDEQ
>NZ_CP053798.1|WP_000095776.1|2579131_2580124_+|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA
MSSKRIIVTAGEPAGIGPDLVLALSAQDWPHQLVVCADKALLAQRAVQLGIQVKLLDYQRDNPVQAQQAGTLLVEHIPLAEPVVAGQLNPANGHYVLKTLERAAKGCMNGEFDAIVTGPVHKGVINRAGVAFSGHTEFFAEQSKTPLVVMMLATEGLRTALVTTHLPLAEVPQAITCERLEQIVHILHKDLVEKFAIAEPKIYVCGLNPHAGEDGVLGMEEIETITPTLQRLREQYGMQLVGPLPADTIFSEKYLQQADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFIRTSVDHGTALDLAGTGQADAGSFWTALAYAIELVDKKAQ
>NZ_CP053798.1|WP_001243262.1|2580137_2580953_+|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA
MRNDVHLGHKARKRFGQNFLNDPYIIDGIVSAINPKPGQNLVEIGPGLGAITEPVGREVDKFTVIELDRDLAERLRNHPELASKLTIHEGDAMRFDFKQLVKPNNKLRVFGNLPYNISTPLMFHLFEFHRDIQDMHFMLQKEVVNRLAAGPGTKAYGRLTVMAQYYCKVVPVLEVPPSAFVPPPKVDSAVVRLVPYEDLPHPATSLEWLDRVVREGFNQRRKTVRNCYKGLAEPETLETLGINPGMRPENLTLAQFVALANWLDATHKTHA
>NZ_CP053798.1|WP_000383338.1|2581024_2581405_+|Co2+/Mg2+-efflux-protein-ApaG
MDVSLPCIKIQVQTRYIEEQSNPEYQRFVFAYLITIKNLSSQTVQLMSRRWLITDADGKQTVVEGDGVVGEQPRIKANDEYTYSSGTALDTPVGVMQGQYLMIDEQGESFTVEIEPFRLAVPHVLN
>NZ_CP053798.1|WP_057550627.1|2581415_2582225_+|symmetrical-bis(5'-nucleosyl)-tetraphosphatase
MANYIVGDIQGCFDELQQLLKQAEFNSQLDTLWFAGDLVARGPKSLETLRFAYQLGDAARVVLGNHDLHLLSVALGHHSAKRRDQTQAILDAPDAAPLLDWLRQQPLLAEHQEFVLCHAGISPQWDLATARQAAQEVESVLRSPEWSTLIEQMYSDQPDAWHPTLQGIDRLRYIVNVFTRMRFCFPDGRLDMQCKLPPKEVTDGSLLPWFQLPQRIALEKTVIFGHWAALEGYVSETVIGLDTGCVWGGTLTMLRWEDKHYFSQAALPA
>NZ_CP053798.1|WP_053034672.1|2582374_2582872_-|type-3-dihydrofolate-reductase
MMISMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVVMGRKTYQSIGRPLPGRHNIVISRDASLQIEGVDVVTSIEAALAKAGEVDEVMIIGGGSLYAACLPMAHKLYITEIHAKLEGDTQFPEWGSDWLERSREHYPADEKNAYGMDFVIFERQYPLPT
>NZ_CP053798.1|WP_162813836.1|2582884_2583358_-|threonine/serine-exporter-family-protein
MLSWDLFFGLLNDMLFAAIPAVGFALVFNVPVPALKYCALGGALGHGSRYLMMHFGVPIEWASFFAATLVGMVGVYWSRRFLAHPKVFTVAALIPMVPGVFAFKAMIALVEINHVGFSPELMEALLENFLKAMFIIAGLAVGLAVPGLLFYRRKPII

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP053798_1	1.1\|2571274\|37\|NZ_CP053798\|PILER-CR	2571274-2571310	37	NC_049942	Escherichia phage JLK-2012, complete sequence	23524-23560	4	0.892
NZ_CP053798_1	1.1\|2571274\|37\|NZ_CP053798\|PILER-CR	2571274-2571310	37	NC_021742	Serratia liquefaciens ATCC 27592 plasmid unnamed, complete sequence	35428-35464	4	0.892

1. spacer 1.1|2571274|37|NZ_CP053798|PILER-CR matches to NC_049942 (Escherichia phage JLK-2012, complete sequence) position: , mismatch: 4, identity: 0.892

taggtcgccagttcgattccggcagccggcaccactt	CRISPR spacer
caggtcgccagttcgattccggtagccggcaccatat	Protospacer
.*********************.***********. *

2. spacer 1.1|2571274|37|NZ_CP053798|PILER-CR matches to NC_021742 (Serratia liquefaciens ATCC 27592 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.892

taggtcgccagttcgattccggcagccggcaccactt	CRISPR spacer
taggtcaccagttcgattccggtagccggcaccaatc	Protospacer
******.***************.*********** *.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

650170 : 656663

Staphylococcus_phage(66.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002053364.1\|650170_651304_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	3.1e-64	40.1
WP_033932838.1\|651315_652566_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	1.7e-100	49.7
WP_000543544.1\|652665_653115_+	transcriptional regulator NrdR	NA	NA	NA	NA
WP_094392063.1\|653140_654244_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	1.5e-44	33.3
WP_094392062.1\|654248_654902_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	8.9e-32	38.2
WP_094392061.1\|654942_656052_+	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	8.8e-64	39.8
WP_000864130.1\|656192_656663_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	6.8e-34	48.7

DBSCAN-SWA_2

1506277 : 1530024

Vibrio_phage(72.73%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000948761.1\|1506277_1506589_+	hypothetical protein	E3U9J1	Vibrio_phage	6.6e-09	100.0
WP_102786687.1\|1506719_1507079_+	phage protein	G8IRV3	Vibrio_phage	8.5e-61	93.2
WP_102786848.1\|1507148_1507469_-	hypothetical protein	NA	NA	NA	NA
WP_102786847.1\|1507554_1507797_-	ADP-ribosyl-(dinitrogen reductase) hydrolase	NA	NA	NA	NA
WP_102786846.1\|1508087_1508285_-	YegP family protein	NA	NA	NA	NA
WP_175233871.1\|1509140_1510508_-	toxin	Q64EV0	Vibrio_phage	2.9e-258	98.7
WP_001160095.1\|1510510_1510855_-	DUF2523 domain-containing protein	Q64EV1	Vibrio_phage	4.8e-61	100.0
WP_053034455.1\|1510854_1512189_-	hypothetical protein	G8IRU9	Vibrio_phage	3.8e-69	82.0
WP_000672170.1\|1512321_1512531_-	hypothetical protein	G8IRU8	Vibrio_phage	1.1e-20	81.2
WP_002043879.1\|1512564_1512795_-	hypothetical protein	G8IRU7	Vibrio_phage	4.6e-36	97.4
WP_069217175.1\|1512808_1513120_-	chemotaxis protein	Q2PZB5	Vibrio_virus	7.7e-42	81.8
WP_142738266.1\|1515284_1515524_-	hypothetical protein	O56843	Vibrio_virus	9.8e-29	80.5
WP_033932564.1\|1515707_1516064_+	hypothetical protein	Q9MCC3	Vibrio_phage	8.0e-43	75.2
WP_175233872.1\|1516386_1530024_-	MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin RtxA	B3Y8K3	Vibrio_virus	8.4e-07	100.0

DBSCAN-SWA_3

2253254 : 2260447

Anguillid_herpesvirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001162850.1\|2253254_2253683_-	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	1.0e-20	38.4
WP_069647789.1\|2253886_2255176_-	aminopeptidase PepB	Q6GYZ8	Mycoplasma_phage	1.0e-34	34.3
WP_000872176.1\|2255395_2255590_-	Fe-S cluster assembly protein IscX	NA	NA	NA	NA
WP_001124187.1\|2255638_2255977_-	ISC system 2Fe-2S type ferredoxin	NA	NA	NA	NA
WP_175233922.1\|2255990_2257841_-	Fe-S protein assembly chaperone HscA	A0A0N9QXN8	Chrysochromulina_ericina_virus	1.3e-104	40.7
WP_001105750.1\|2257864_2258380_-	co-chaperone HscB	NA	NA	NA	NA
WP_000301571.1\|2258428_2258752_-	iron-sulfur cluster assembly protein IscA	A0A2H4N7N5	Lake_Baikal_phage	3.0e-25	50.5
WP_000331703.1\|2258812_2259196_-	Fe-S cluster assembly scaffold IscU	A0A218MKD1	uncultured_virus	5.4e-53	78.2
WP_000775249.1\|2259232_2260447_-	IscS subfamily cysteine desulfurase	A0A0H3TPH2	Faustovirus	8.8e-33	30.8

DBSCAN-SWA_4

2491917 : 2499142

uncultured_Mediterranean_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001914090.1\|2491917_2492805_+	cysteine synthase CysM	A0A1X9I5K7	Streptococcus_phage	2.4e-56	41.1
WP_175233930.1\|2493072_2495661_+	DNA mismatch repair protein MutS	A0A1V0SC35	Catovirus	1.7e-33	23.0
WP_175233931.1\|2495754_2496762_-	RNA polymerase sigma factor RpoS	F4YCU2	Synechococcus_phage	6.0e-35	34.2
WP_000177561.1\|2496835_2497771_-	murein hydrolase activator NlpD	D7RWE0	Brochothrix_phage	7.8e-05	34.7
WP_000002982.1\|2497770_2498397_-	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	2.0e-36	52.1
WP_162923881.1\|2498389_2499142_-	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	1.4e-68	52.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP053799

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP053798

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection