CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP053805	Vibrio cholerae strain SL6Y chromosome 2, complete sequence	1 crisprs	csa3,RT,cas3	0	0	1	0
NZ_CP053804	Vibrio cholerae strain SL6Y chromosome 1, complete sequence	1 crisprs	RT,cas3,DEDDh,DinG,csx1,csa3	0	1	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP053804_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053804_1

2527681-2527924

Orphan

Consensus_repeat	Method
AAAATGTGCCTCCTTAGCTCAGTCGGTAGAGCAACGGACTGATAATCCG	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP053804_1

>merge|NZ_CP053804|1|2527681-2527924|PILER-CR
TGTGCCGGCTTAGCTCAGTAGGTAGAGCAACTGACTTGTAATCAGTAGGTCGCCAGTTCGATTCCGGCAGCCGGCACCACTTAAAATTTGCCTCGATAGCTCAGTCGGTAGAGCAGAGGATTGAAAATCCTCGTGTCGGTGGTTCGATTCCGCCTCGAGGCACCACTATTAAAAGTTGTGCCATAGACACAATAAAAATTGTTCCTCCTTAGCTCAGTCGGTAGAGCGACGGACTGTTAATCCG

>NZ_CP053804|1|1|2527681-2527924|PILER-CR
TGTGCCGGCTTAGCTCAGTAGGTAGAGCAACTGACTTGTAATCAGTAGG	TCGCCAGTTCGATTCCGGCAGCCGGCACCACTTAAAA
TTTGCCTCGATAGCTCAGTCGGTAGAGCAGAGGATTGAAAATCCTCGTG	TCGGTGGTTCGATTCCGCCTCGAGGCACCACTATTAAAAGTTGTGCCATAGACACAATAAAAAT
TGTTCCTCCTTAGCTCAGTCGGTAGAGCGACGGACTGTTAATCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053804.1\|WP_175230819.1\|2528214_2529840_+\|cache-domain-containing-protein	unknown	unknown	gnl\|CDD\|223910
NZ_CP053804.1\|WP_054104352.1\|2521079_2521682_+\|XTP/dITP-diphosphatase	unknown	unknown	gnl\|CDD\|234648
NZ_CP053804.1\|WP_000124738.1\|2525948_2526221_+\|oxidative-damage-protection-protein	unknown	unknown	gnl\|CDD\|180059
NZ_CP053804.1\|WP_175230821.1\|2534302_2535598_+\|peptidylprolyl-isomerase-SurA	unknown	unknown	gnl\|CDD\|236758
NZ_CP053804.1\|WP_001277601.1\|2531898_2534250_+\|LPS-assembly-protein-LptD	unknown	unknown	gnl\|CDD\|235158
NZ_CP053804.1\|WP_000954087.1\|2539340_2539814_-\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|182143
NZ_CP053804.1\|WP_001243262.1\|2536593_2537409_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	unknown	unknown	gnl\|CDD\|234708
NZ_CP053804.1\|WP_001233674.1\|2520578_2521010_+\|DUF4426-domain-containing-protein	unknown	unknown	gnl\|CDD\|379616
NZ_CP053804.1\|WP_000005581.1\|2523914_2524634_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NZ_CP053804.1\|WP_000741915.1\|2520242_2520533_+\|YggU-family-protein	unknown	unknown	gnl\|CDD\|179931
NZ_CP053804.1\|WP_000035023.1\|2537871_2538681_+\|symmetrical-bis(5'-nucleosyl)-tetraphosphatase	unknown	unknown	gnl\|CDD\|234673
NZ_CP053804.1\|WP_000095775.1\|2535587_2536580_+\|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA	unknown	unknown	gnl\|CDD\|234696
NZ_CP053804.1\|WP_000973541.1\|2538830_2539328_-\|type-3-dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|365932
NZ_CP053804.1\|WP_175230816.1\|2524873_2525935_+\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|182805
NZ_CP053804.1\|WP_000383338.1\|2537480_2537861_+\|Co2+/Mg2+-efflux-protein-ApaG	unknown	unknown	gnl\|CDD\|180098
NZ_CP053804.1\|WP_175230813.1\|2521675_2522851_+\|radical-SAM-family-heme-chaperone-HemW	unknown	unknown	gnl\|CDD\|235550
NZ_CP053804.1\|WP_000546924.1\|2530885_2531740_-\|co-chaperone-DjlA	unknown	unknown	gnl\|CDD\|236512
NZ_CP053804.1\|WP_000805056.1\|2522883_2523804_-\|glutaminase-B	unknown	unknown	gnl\|CDD\|234880
NZ_CP053804.1\|WP_033929140.1\|2526322_2527450_+\|membrane-bound-lytic-murein-transglycosylase-MltC	unknown	unknown	gnl\|CDD\|183271
NZ_CP053804.1\|WP_057550646.1\|2519685_2520243_+\|YggT-family-protein	unknown	unknown	gnl\|CDD\|223833

Protein	Function_ID	Function_description	E-value
NZ_CP053804.1\|WP_175230819.1\|2528214_2529840_+\|cache-domain-containing-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	2.13611e-58
NZ_CP053804.1\|WP_054104352.1\|2521079_2521682_+\|XTP/dITP-diphosphatase	gnl\|CDD\|234648	PRK00120, PRK00120, dITP/XTP pyrophosphatase; Reviewed.	1.66313e-127
NZ_CP053804.1\|WP_000124738.1\|2525948_2526221_+\|oxidative-damage-protection-protein	gnl\|CDD\|180059	PRK05408, PRK05408, oxidative damage protection protein; Provisional.	5.47988e-59
NZ_CP053804.1\|WP_175230821.1\|2534302_2535598_+\|peptidylprolyl-isomerase-SurA	gnl\|CDD\|236758	PRK10770, PRK10770, peptidyl-prolyl cis-trans isomerase SurA; Provisional.	3.0816e-156
NZ_CP053804.1\|WP_001277601.1\|2531898_2534250_+\|LPS-assembly-protein-LptD	gnl\|CDD\|235158	PRK03761, PRK03761, LPS assembly outer membrane complex protein LptD; Provisional.	0
NZ_CP053804.1\|WP_000954087.1\|2539340_2539814_-\|threonine/serine-exporter-family-protein	gnl\|CDD\|182143	PRK09917, PRK09917, threonine/serine exporter.	7.45224e-67
NZ_CP053804.1\|WP_001243262.1\|2536593_2537409_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	gnl\|CDD\|234708	PRK00274, ksgA, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA.	3.27746e-146
NZ_CP053804.1\|WP_001233674.1\|2520578_2521010_+\|DUF4426-domain-containing-protein	gnl\|CDD\|379616	pfam14467, DUF4426, Domain of unknown function (DUF4426). Members of this entry are found mostly in g-proteobacteria, especially in Vibrio. Strangely enough, there seems to be one eukaryotic homolog in Nematostella vectensis (NEMVEDRAFT_v1g226006), where the PA0388-like domain is fused with a domain homogous to the Methionine biosynthesis protein MetW (see below). In several Pseudomonas species, but also in Vibrio vulnificus and Azotobacter vinelandii PA0388 homologs are genomic neighbors of Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) and Methionine biosynthesis protein MetW. On the other hand, in most Vibrio species it appears as a part of a conserved operon involved in possible response to stress.	6.80534e-67
NZ_CP053804.1\|WP_000005581.1\|2523914_2524634_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	4.57395e-111
NZ_CP053804.1\|WP_000741915.1\|2520242_2520533_+\|YggU-family-protein	gnl\|CDD\|179931	PRK05090, PRK05090, hypothetical protein; Validated.	9.17224e-61
NZ_CP053804.1\|WP_000035023.1\|2537871_2538681_+\|symmetrical-bis(5'-nucleosyl)-tetraphosphatase	gnl\|CDD\|234673	PRK00166, apaH, symmetrical bis(5'-nucleosyl)-tetraphosphatase.	3.55814e-169
NZ_CP053804.1\|WP_000095775.1\|2535587_2536580_+\|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA	gnl\|CDD\|234696	PRK00232, pdxA, 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed.	0
NZ_CP053804.1\|WP_000973541.1\|2538830_2539328_-\|type-3-dihydrofolate-reductase	gnl\|CDD\|365932	pfam00186, DHFR_1, Dihydrofolate reductase.	3.63754e-91
NZ_CP053804.1\|WP_175230816.1\|2524873_2525935_+\|A/G-specific-adenine-glycosylase	gnl\|CDD\|182805	PRK10880, PRK10880, adenine DNA glycosylase.	0
NZ_CP053804.1\|WP_000383338.1\|2537480_2537861_+\|Co2+/Mg2+-efflux-protein-ApaG	gnl\|CDD\|180098	PRK05461, apaG, CO2+/MG2+ efflux protein ApaG; Reviewed.	1.16069e-74
NZ_CP053804.1\|WP_175230813.1\|2521675_2522851_+\|radical-SAM-family-heme-chaperone-HemW	gnl\|CDD\|235550	PRK05660, PRK05660, radical SAM family heme chaperone HemW.	0
NZ_CP053804.1\|WP_000546924.1\|2530885_2531740_-\|co-chaperone-DjlA	gnl\|CDD\|236512	PRK09430, djlA, co-chaperone DjlA.	1.60415e-153
NZ_CP053804.1\|WP_000805056.1\|2522883_2523804_-\|glutaminase-B	gnl\|CDD\|234880	PRK00971, PRK00971, glutaminase; Provisional.	0
NZ_CP053804.1\|WP_033929140.1\|2526322_2527450_+\|membrane-bound-lytic-murein-transglycosylase-MltC	gnl\|CDD\|183271	PRK11671, mltC, membrane-bound lytic murein transglycosylase MltC.	4.84531e-156
NZ_CP053804.1\|WP_057550646.1\|2519685_2520243_+\|YggT-family-protein	gnl\|CDD\|223833	COG0762, COG0762, Predicted integral membrane protein [Function unknown].	2.45272e-12

>NZ_CP053804.1|WP_033929140.1|2526322_2527450_+|membrane-bound-lytic-murein-transglycosylase-MltC
MRKLVLCITALLLSGCSREFIEKIYDVDYEPTNRFAKNLAELPGQFQKDTAALDALINSFSGNIEKRWGRRELKIAGKNNYVKYIDNYLSRSEVNFTEGRIIVETVSPIDPKAHLRNAIITTLLTPDDPAHVDLFSSKDIELKGQPFLYQQVLDQDGQPIQWSWRANRYADYLIANHLKVKQVDFKKAYYVEIPMVKDQIDIRGYKYASIVRKASRKYDIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAGRDVFKLVKNRSGEPSPEYLFNPENNIDTGTAYFYILKNRYLKEVRHPTSLEYSMISAYNGGTGGVLNTFSRDRQRAMRDLNALQPNQVYWALTKKHPNAEARRYLEKVTKFKKEFNAG
>NZ_CP053804.1|WP_000124738.1|2525948_2526221_+|oxidative-damage-protection-protein
MARTVFCTRLQKEADGLDFQLYPGELGKRIFDNICKEAWAQWQTKQTMLINEKKLNMMDPEHRKLLEQEMVNFLFEGKEVHIEGYTPPAK
>NZ_CP053804.1|WP_175230816.1|2524873_2525935_+|A/G-specific-adenine-glycosylase
MTPFAQAILTWYDAYGRKNLPWQQNKNAYRVWLSEIMLQQTQVATVIPYFERFLERFPTVQALAAAPQDEVLHFWTGLGYYARARNLHKAAQTVVNEYGGEFPTDLEQMNALPGVGRSTAAAVLSSVYKKPHAILDGNVKRTLARCFAVEGWPGQKSVENQLWHYAEMHTPKVDVDKYNQAMMDMGAMICTRSKPKCSLCPVESFCLAKQQGNPQEYPGKKPKTDKPVKATWFVMLYHDNTVWLEQRPQSGIWGGLYCFPQSEIANIQTTIDQRAIGDSTITSQKTLIAFRHTFSHYHLDITPILLQLSRKPDIVMEGSKGLWYNLSQPDEIGLAAPVKQLLHSLPFDIDSHI
>NZ_CP053804.1|WP_000005581.1|2523914_2524634_-|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MSEVITQEYTEDGKVLRRIRSFVRREGRLTKGQEAAMKECWPTMGIDYQPELLDWQQVFGNDNPVVLEIGFGMGASLVEMAKNAPEKNFLGIEVHSPGVGACLASAREAGVTNLRVMCHDAVEVFAHMIPDNSLHTLQLFFPDPWHKKRHHKRRIVQLEFAEMVRQKLIIGSGVFHMATDWENYAEHMIEVMNQAPGFANLATDGDYIPRPDERPLTKFEQRGHRLGHGVWDIKYQRTA
>NZ_CP053804.1|WP_000805056.1|2522883_2523804_-|glutaminase-B
MKPTAEILASIIEEVRPLTGQGKVADYIPALAKVPSEKLGIAVFTNQGEVITAGDAQEGFSIQSISKVLSLTLAMGLYQPDELWSRVGKEPSGQAFNSLIQLEMEHGIPRNPFINAGAIVVCDMLQSRLSAPRQRLLEFVRQLSGEPLIAYDKVVAASEMMHSDRNAAIAYLMRSFGNFHNEVIPVLHNYFHACALKMSCVELAKTFSYLANKGVSVVTGETVITPTQSKQTNALLATCGLYDGAGEFAYRVGMPGKSGVGGGIIAVVPGEMTIAVWSPALDQSGNSLAGTRALELLAQRIGRSIF
>NZ_CP053804.1|WP_175230813.1|2521675_2522851_+|radical-SAM-family-heme-chaperone-HemW
MLTPPPLSLYIHIPWCVQKCPYCDFNSHAQKGDIPEQEYLDALLEDLDRDIERYQLKGDPRLLHSIFIGGGTPSLISAEGIARLLQGVAERIAFKPEIEITMEANPGTIEAQRFAGYRTAGVTRISIGVQSFEPEKLARLGRIHGQQEAVRAAQLAHQIGLNSFNLDLMHGLPDQTPEQALADLDQAIALNPPHLSWYQLTIEPNTLFYSKPPKLPDEDALWDIFDLGHQKLSDAGYVQYEISGYSKPGYQCQHNLNYWRFGDYLGIGCGAHGKLSFADGRIVRTTKTKHPRGYLAALNNLAKAYLDSEQLVADQDKPFEFFMNRFRLIEPCPKADFTATTGLTIDVIRPTLDWAISEGYLSEDDQHWQITEKGKLFLNDLLEAFMADEEE
>NZ_CP053804.1|WP_054104352.1|2521079_2521682_+|XTP/dITP-diphosphatase
MKKIVLATGNQGKVREMADLLSDFGFDVIAQSEFNVPEAAETGTTFIENAIIKARHAAQITGLPAIADDSGLEVDYLNGAPGIYSARYAGEHASDGDNLNKLLAAMQDVPDDQRSARFHCVLVLMRHADDPTPIVCHGKWEGKILTAPHGSNGFGYDPIFWVPEENCASAELEPVRKKQLSHRGKALQKLFKAIEEQRTC
>NZ_CP053804.1|WP_001233674.1|2520578_2521010_+|DUF4426-domain-containing-protein
MRKWMMSLLLTLLALPASAEQQKTIKDIEVHYSAFNSTFLTPKVASSYQLTRNGYTAILNISVLDRASLGKPATEAKLTGHAKNLIGNLRELSFKQVKEGNAIYYLAEVPISNEEMLTFDIDVDAGLKGAGKLTFSQKFYTEQ
>NZ_CP053804.1|WP_000741915.1|2520242_2520533_+|YggU-family-protein
MAAVWREGDDLLLRLYIQPKASRDSIVGLHGEELKVAITAPPIDGKANAHLSKYLAKLCKVAKGSVVIEKGELGRHKQVRILQPSQIPAEITALIE
>NZ_CP053804.1|WP_057550646.1|2519685_2520243_+|YggT-family-protein
MNSLSFLINTLFDLYIMVVILRIWLQAARADFYNPFSQFIVKATQPVVGPLRRVIPSIGSIDLATIVFAYVLCVLKFMALVLIASNGSVSFSADFLFLGLLSLIKAAGGLLFWVLLIRAILSWVSQGRSPIEYVFHQLTEPMLAPIRRIIPVMGGFDLSILVLFIVLQFANFLMGDVIGPIWYQL
>NZ_CP053804.1|WP_175230819.1|2528214_2529840_+|cache-domain-containing-protein
MKLKTQAYLLSAIILAALLALTATGLWTLRVASDLDNKARVTELFNSAYSILTEVEKLAQEGKMSEPEAKALATRLMRNNLYKDNEYVYVADENMTFVATPLDPQLHDTSFHDFKDGKGNSVGRLIQDVLRHQSGKLVEYTWTQKQADGSIEEKLSIARKTPHWGWVVGTGIGFNEVNARFWSTAQWQLSLCVVIAVAILSLLLVAIRKILLIIGGEPNEVRSAVQAVAQGRIRREFAIKAPKESIYGAVQQMSSSLADLVAKLEQSMVALRSELAGAGTRAKSIAELTDSQQQSTAMIATAMTEMASSANQVADSARDTAFNTDQADQQSQHTQKLIHNTVSNIQGLATQLQTASTAVADLDLDVKNIAKVLDVIGDIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRNLAGRTQTSTKEIQQMIHNLQEGSRNAIQTIQICGQTSQSSVQESENAASALALIVSALESVSSMSHQIATAAAEQTQVSDDIARRINMIEESGSKLSRVVMESHNSTQTLTKLARELEQWAAHFEVTR
>NZ_CP053804.1|WP_000546924.1|2530885_2531740_-|co-chaperone-DjlA
MHIFGKILGAFFGFLFGGPFGAIFGIFLGHQFDKARRLNQAGFQSGTFGAGPSQAERQEEFFKSAFSVMGHVAKAKGQVTKEEIQLATIMMDRMNLTLEQKRAAQDAFRDGKESDFPLEQVLERVKIATGGRFDLLQFFLELQVSSAFADGDVHPSERQVLHRIARGLGFSSEQLERRLRMQEAAFRFQQGGGFGGSQQQSHSGQQWQQPSSRHQLADAYEVLGVSESASAQEVKRAYRKLMNEHHPDKLMAKGLPPEMMNVAKEKSQQIQHAYELIRKEKGIK
>NZ_CP053804.1|WP_001277601.1|2531898_2534250_+|LPS-assembly-protein-LptD
MSCFSRTFLAASISAALFAPQIQAEASVDDNRAQLPNGEQCLVNQPEPTNPGQQPINVEADKLEAINGQKATYSGNVVVVQGKKRIAADNVTLHQQENVVVAEGNVQFSDGEIKTHSTKATNHLNTDEMTLENTRYQFLCEPGRGEAVYVSKTGKAVYEIEDGSITSCPDGDNAWRMRASSIDVDQNEEIATFYNPRLEVQNVPVFYLPYLTVPIGDTRKTGFLYPTASYGSRNGYSFEVPIYWNLAPQYDLETTFNYMQKRGTQLNSVFRYLTDFGAGQIKSEYLADDQLHTELGDRWAFQYEHNGIFQQAWKFEIDYSKVSDINYFSDLDSGVGNREDGQLIQEGRATYRSDNWDSALLVRDFQLLTKDTTSTNLPYRLMPQLSYNYYAPETMKYLDLDLVSHVSRFETDARGKPSATRVHIEPGLKIPFSNTWGNWTTEARVLGTYYQQDLDKTTDAKLEESVTRVIPEIRSVAGIVLERDTVLLDDYTQTLEPKIQYLYVPEKYQDNIGLYDSTLLQTDYYGLFRSRKYSGVDRIESANQVSYGASTRFFDSNYKERLNIAFGQIFYLDSKLNPSNKNPDSTSDKTSYSAWAVEMDFNFADYLFYHGGIQYDIDSQAVQLGNSTLEYRVASGYIQANYRYVAKDYIRNTVGDSITNIDDITRDGISQAGILAGYQLSRKWSASGQYYYDLTTDEALEWLANLTYTSDCWYVGFTYSNQLKSWNGNFVTDPYATPIYENNFSFNIGIIGFGTSIGAGSSMTGVDSAGNSLGYGRPFFLNN
>NZ_CP053804.1|WP_175230821.1|2534302_2535598_+|peptidylprolyl-isomerase-SurA
MKLWKPTLISVLSALTLFNAHAEPKQLDSVAVIVNSGVILQSDVDSALKTIKANAKQNKQPLPQETVLREQVLEKLIIDTLQQQEADRIGVKIDDNRLNEAIKEIAKNNQQTQEQLIASVAQEGLTYPEFREQVRKEMAASDARNVLVRRRINILPAEVDTLAELLAQETDATVQYKISHIQLRVDDGQDKSAAETLANKLINDLRNGADFAQMAYAYSKGPKALQGGDWGWMRKEEMPTIFADQIKMQNKGSIIGPFRSGVGFHILKIDDVKGLETVAVTEVNARHILIKPTIILSDEGAQKQLNEFVQRIKNGEVTFAELAQQYSQDPGSAAQKGELGYQTPDLYVPEFKHQIETLPVGQISEPFKTVHGWHIVEVLDRREVDRTDSALKNKAYRILFNRKFNEEASAWLQELRASAFVEVLKDEKDEQ
>NZ_CP053804.1|WP_000095775.1|2535587_2536580_+|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA
MSSKRIIVTAGEPAGIGPDLVLALSAQDWPHQLVVCADKALLAQRATQLGIQVKLLDYQRDNPVQAQQAGTLLVEHISLAEPVVAGQLNPANGHYVLKTLERAAKGCMNGEFDAIVTGPVHKGVINRAGVAFSGHTEFFAEQSKTPLVVMMLATEGLRTALVTTHLPLAEVPQAITCERLEQIVHILHKDLVEKFAIAEPKIYVCGLNPHAGEDGVLGMEEIETITPTLQRLREQYGMQLVGPLPADTIFSEKYLQQADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFIRTSVDHGTALDLAGTGQADAGSFWTALAYAIELVDKKAQ
>NZ_CP053804.1|WP_001243262.1|2536593_2537409_+|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA
MRNDVHLGHKARKRFGQNFLNDPYIIDGIVSAINPKPGQNLVEIGPGLGAITEPVGREVDKFTVIELDRDLAERLRNHPELASKLTIHEGDAMRFDFKQLVKPNNKLRVFGNLPYNISTPLMFHLFEFHRDIQDMHFMLQKEVVNRLAAGPGTKAYGRLTVMAQYYCKVVPVLEVPPSAFVPPPKVDSAVVRLVPYEDLPHPATSLEWLDRVVREGFNQRRKTVRNCYKGLAEPETLETLGINPGMRPENLTLAQFVALANWLDATHKTHA
>NZ_CP053804.1|WP_000383338.1|2537480_2537861_+|Co2+/Mg2+-efflux-protein-ApaG
MDVSLPCIKIQVQTRYIEEQSNPEYQRFVFAYLITIKNLSSQTVQLMSRRWLITDADGKQTVVEGDGVVGEQPRIKANDEYTYSSGTALDTPVGVMQGQYLMIDEQGESFTVEIEPFRLAVPHVLN
>NZ_CP053804.1|WP_000035023.1|2537871_2538681_+|symmetrical-bis(5'-nucleosyl)-tetraphosphatase
MANYIVGDIQGCFDELQQLLKQAEFNSQLDTLWFAGDLVARGPKSLETLRFAYQLGDAARVVLGNHDLHLLSVALGHHSAKRRDQTQAILDAPDAAPLLDWLRQQPLLAEHQEFVLCHAGISPQWDLATARQAAQEVESVLRSPEWSTLIEQMYSDQPDAWHPTLQGIDRLRYIVNAFTRMRFCFPDGRLDMQCKLPPQEVTDGSLLPWFQLPQRIALEKTVIFGHWAALEGYVSETVIGLDTGCVWGGTLTMLRWEDKHYFSQAALPA
>NZ_CP053804.1|WP_000973541.1|2538830_2539328_-|type-3-dihydrofolate-reductase
MMISMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVVMGRKTYQSIGRPLPGRHNIVISRDASLQIEGVDVVTSIEAALAKAGEVDEVMIIGGGSLYAACLPMAHKLYITEIQAKLEGDTQFPEWGSDWLERFREHYPADEKNAYGMDFVIFERQYPLPT
>NZ_CP053804.1|WP_000954087.1|2539340_2539814_-|threonine/serine-exporter-family-protein
MLSWDLFFGLLNDMFFAAIPAVGFALVFNVPVPALKYCALGGALGHGSRYLMMHFGVPIEWASFFAATLVGMVGVYWSRRFLAHPKVFTVAALIPMVPGVFAFKAMIALVEINHVGFSPELMEALLENFLKAMFIIAGLAVGLAVPGLLFYRRKPII

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP053804_1	1.1\|2527730\|37\|NZ_CP053804\|PILER-CR	2527730-2527766	37	NC_049942	Escherichia phage JLK-2012, complete sequence	23524-23560	4	0.892
NZ_CP053804_1	1.1\|2527730\|37\|NZ_CP053804\|PILER-CR	2527730-2527766	37	NC_021742	Serratia liquefaciens ATCC 27592 plasmid unnamed, complete sequence	35428-35464	4	0.892

1. spacer 1.1|2527730|37|NZ_CP053804|PILER-CR matches to NC_049942 (Escherichia phage JLK-2012, complete sequence) position: , mismatch: 4, identity: 0.892

taggtcgccagttcgattccggcagccggcaccactt	CRISPR spacer
caggtcgccagttcgattccggtagccggcaccatat	Protospacer
.*********************.***********. *

2. spacer 1.1|2527730|37|NZ_CP053804|PILER-CR matches to NC_021742 (Serratia liquefaciens ATCC 27592 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.892

taggtcgccagttcgattccggcagccggcaccactt	CRISPR spacer
taggtcaccagttcgattccggtagccggcaccaatc	Protospacer
******.***************.*********** *.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

657087 : 663703

Staphylococcus_phage(66.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000210573.1\|657087_658221_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	1.4e-64	40.4
WP_175229926.1\|658232_659483_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	6.6e-100	49.2
WP_000543544.1\|659582_660032_+	transcriptional regulator NrdR	NA	NA	NA	NA
WP_069648269.1\|660056_661160_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	7.0e-45	33.6
WP_000493874.1\|661164_661818_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.2e-31	38.2
WP_001122865.1\|661858_662968_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	6.7e-64	39.8
WP_000864130.1\|663232_663703_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	6.8e-34	48.7

DBSCAN-SWA_2

1521247 : 1544166

Vibrio_phage(91.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_175230365.1\|1521247_1521559_+	hypothetical protein	E3U9J1	Vibrio_phage	3.3e-08	100.0
WP_175231062.1\|1521674_1522046_+	phage protein	G8IRV3	Vibrio_phage	1.5e-63	95.1
WP_175230368.1\|1522061_1522907_-	DUF3037 domain-containing protein	NA	NA	NA	NA
WP_175230369.1\|1522903_1523614_-	hypothetical protein	NA	NA	NA	NA
WP_175230372.1\|1524260_1525628_-	toxin	Q64EV0	Vibrio_phage	3.2e-257	98.2
WP_001160095.1\|1525630_1525975_-	DUF2523 domain-containing protein	Q64EV1	Vibrio_phage	4.8e-61	100.0
WP_175230374.1\|1525974_1527324_-	hypothetical protein	G8IRU9	Vibrio_phage	8.2e-56	67.8
WP_175230376.1\|1527456_1527666_-	hypothetical protein	G8IRU8	Vibrio_phage	7.2e-20	79.7
WP_002043879.1\|1527699_1527930_-	hypothetical protein	G8IRU7	Vibrio_phage	4.6e-36	97.4
WP_001896626.1\|1527932_1528295_-	DUF1293 family protein	Q783U4	Vibrio_phage	1.6e-35	61.0
WP_000870098.1\|1528301_1529597_-	replication initiation factor domain-containing protein	R9TNS0	Vibrio_phage	2.5e-171	66.0
WP_000442957.1\|1529593_1529785_-	hypothetical protein	R9TRU0	Vibrio_phage	1.7e-15	63.9
WP_175230379.1\|1529909_1530266_+	regulator	Q9MCC3	Vibrio_phage	7.5e-33	58.7
WP_175230382.1\|1530588_1544166_-	MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin RtxA	B3Y8K3	Vibrio_virus	8.4e-07	100.0

DBSCAN-SWA_3

2226604 : 2233797

Anguillid_herpesvirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001162850.1\|2226604_2227033_-	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	1.0e-20	38.4
WP_000107234.1\|2227236_2228526_-	aminopeptidase PepB	Q6GYZ8	Mycoplasma_phage	6.5e-34	34.0
WP_000872174.1\|2228745_2228940_-	Fe-S cluster assembly protein IscX	NA	NA	NA	NA
WP_001124187.1\|2228988_2229327_-	ISC system 2Fe-2S type ferredoxin	NA	NA	NA	NA
WP_001196556.1\|2229340_2231191_-	Fe-S protein assembly chaperone HscA	A0A0N9QXN8	Chrysochromulina_ericina_virus	9.1e-106	41.1
WP_001105750.1\|2231214_2231730_-	co-chaperone HscB	NA	NA	NA	NA
WP_000301571.1\|2231778_2232102_-	iron-sulfur cluster assembly protein IscA	A0A2H4N7N5	Lake_Baikal_phage	3.0e-25	50.5
WP_000331703.1\|2232162_2232546_-	Fe-S cluster assembly scaffold IscU	A0A218MKD1	uncultured_virus	5.4e-53	78.2
WP_000775253.1\|2232582_2233797_-	IscS subfamily cysteine desulfurase	A0A0H3TPH2	Faustovirus	1.1e-32	30.5

DBSCAN-SWA_4

2467061 : 2474285

uncultured_Mediterranean_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001279364.1\|2467061_2467949_+	cysteine synthase CysM	A0A1X9I5K7	Streptococcus_phage	4.1e-56	41.1
WP_175230791.1\|2468215_2470804_+	DNA mismatch repair protein MutS	A0A1V0SC35	Catovirus	2.2e-33	23.0
WP_000116735.1\|2470897_2471905_-	RNA polymerase sigma factor RpoS	F4YCU2	Synechococcus_phage	6.0e-35	34.2
WP_000177559.1\|2471978_2472914_-	murein hydrolase activator NlpD	D7RWE0	Brochothrix_phage	7.8e-05	34.7
WP_044126958.1\|2472913_2473540_-	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	5.2e-37	52.7
WP_044126957.1\|2473532_2474285_-	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	2.8e-69	53.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP053805

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP053805_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053805_1

571383-571514

Orphan

Consensus_repeat	Method
ATAACGCCCGCCTAAGGGGCTGACAACGCATTACCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP053805_1

>merge|NZ_CP053805|1|571383-571514|CRISPRCasFinder
ATAACGCCCGCCTAAGGGGCTGACAACGCATTACCACTAAACTCAAACACAACAACTGCAACCACCGCGGCTCATTACTGATTTTATGGATTAAGCATAACGCCCGCCTAAGGGGCTGGCAACGCATTACCA

>NZ_CP053805|1|1|571383-571514|CRISPRCasFinder
ATAACGCCCGCCTAAGGGGCTGACAACGCATTACCA	CTAAACTCAAACACAACAACTGCAACCACCGCGGCTCATTACTGATTTTATGGATTAAGC
ATAACGCCCGCCTAAGGGGCTGGCAACGCATTACCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053805.1\|WP_043993102.1\|569381_569666_-\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|224278
NZ_CP053805.1\|WP_001107719.1\|566604_566847_+\|type-II-toxin-antitoxin-system-ParD-family-antitoxin	unknown	unknown	gnl\|CDD\|281658
NZ_CP053805.1\|WP_001915058.1\|567973_568246_+\|DUF1778-domain-containing-protein	unknown	unknown	gnl\|CDD\|226860
NZ_CP053805.1\|WP_175231601.1\|574685_574955_+\|type-II-toxin-antitoxin-system-YafQ-family-toxin	unknown	unknown	gnl\|CDD\|225583
NZ_CP053805.1\|WP_175231591.1\|566843_567143_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|226194
NZ_CP053805.1\|WP_000772125.1\|570486_570723_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240845
NZ_CP053805.1\|WP_001162670.1\|573201_573489_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|282822
NZ_CP053805.1\|WP_001232701.1\|572873_573191_-\|HigA-family-addiction-module-antidote-protein	unknown	unknown	gnl\|CDD\|225635
NZ_CP053805.1\|WP_175231597.1\|573529_573652_-\|acetyltransferase	unknown	unknown	unknown
NZ_CP053805.1\|WP_175231595.1\|572129_572726_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_CP053805.1\|WP_174500467.1\|567260_567743_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_CP053805.1\|WP_175231593.1\|569836_570223_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239217
NZ_CP053805.1\|WP_000982260.1\|568242_568740_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379326
NZ_CP053805.1\|WP_017047369.1\|568900_569224_-\|ion-tolerance-protein-CutA	unknown	unknown	gnl\|CDD\|225860
NZ_CP053805.1\|WP_113629352.1\|571656_571866_-\|DUF645-family-protein	unknown	unknown	gnl\|CDD\|282699
NZ_CP053805.1\|WP_000491261.1\|570909_571299_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319923
NZ_CP053805.1\|WP_080478885.1\|574982_575093_-\|DUF3265-domain-containing-protein	unknown	unknown	gnl\|CDD\|288509
NZ_CP053805.1\|WP_069648548.1\|575089_576628_-\|Retron-type-reverse-transcriptase	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|238824
NZ_CP053805.1\|WP_001258569.1\|574414_574693_+\|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin	unknown	unknown	gnl\|CDD\|367879
NZ_CP053805.1\|WP_175231599.1\|573724_574129_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP053805.1\|WP_043993102.1\|569381_569666_-\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	2.11145e-12
NZ_CP053805.1\|WP_001107719.1\|566604_566847_+\|type-II-toxin-antitoxin-system-ParD-family-antitoxin	gnl\|CDD\|281658	pfam03693, ParD_antitoxin, Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH. ParD is the antitoxin of a bacterial toxin-antitoxin gene pair. The cognate toxin is ParE in, pfam05016. The family contains several related antitoxins from Cyanobacteria, Proteobacteria and Actinobacteria. Antitoxins of this class carry an N-terminal ribbon-helix-helix domain, RHH, that is highly conserved across all type II bacterial antitoxins, which dimerizes with the RHH domain of a second VapB molecule. A hinge section follows the RHH, with an additional pair of flexible alpha helices at the C-terminus. This C-terminus is the toxin-binding region of the dimer, and so is specific to the cognate toxin, whereas the RHH domain has the specific function of lying across the RNA-binding groove of the toxin dimer and inactivating the active-site - a more general function of all type II antitoxins.	3.00822e-38
NZ_CP053805.1\|WP_001915058.1\|567973_568246_+\|DUF1778-domain-containing-protein	gnl\|CDD\|226860	COG4453, COG4453, Uncharacterized protein conserved in bacteria [Function unknown].	2.04108e-21
NZ_CP053805.1\|WP_175231601.1\|574685_574955_+\|type-II-toxin-antitoxin-system-YafQ-family-toxin	gnl\|CDD\|225583	COG3041, COG3041, Uncharacterized protein conserved in bacteria [Function unknown].	1.41068e-39
NZ_CP053805.1\|WP_175231591.1\|566843_567143_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|226194	COG3668, ParE, Plasmid stabilization system protein [General function prediction only].	1.56899e-27
NZ_CP053805.1\|WP_000772125.1\|570486_570723_+\|hypothetical-protein	gnl\|CDD\|240845	cd12399, RRM_HP0827_like, RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins. This subfamily corresponds to the RRM of H. pylori HP0827, a putative ssDNA-binding protein 12rnp2 precursor, containing one RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain). The ssDNA binding may be important in activation of HP0827. .	1.54729e-23
NZ_CP053805.1\|WP_001162670.1\|573201_573489_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|282822	pfam05015, HigB-like_toxin, RelE-like toxin of type II toxin-antitoxin system HigB. This family carries several different examples of type II bacterial toxins of toxin-antitoxin systems including many HigB-like ones. The fold is referred to as the RelE/YoeB/Txe/Yeeu fold suggesting all examples of these are present in this family. Several plasmids with proteic killer gene-systems have been reported. All of them encode a stable toxin and an unstable antidote. Upon loss of the plasmid, the less stable inhibitor is inactivated more rapidly than the toxin, allowing the toxin to be activated. The activation of these systems results in cell filamentation and cessation of viable cell production. It has been verified that both the stable killer and the unstable inhibitor of the systems are short polypeptides. This family corresponds to the toxin.	2.17924e-43
NZ_CP053805.1\|WP_001232701.1\|572873_573191_-\|HigA-family-addiction-module-antidote-protein	gnl\|CDD\|225635	COG3093, VapI, Plasmid maintenance system antidote protein [General function prediction only].	4.36896e-38
NZ_CP053805.1\|WP_175231595.1\|572129_572726_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	8.6106e-12
NZ_CP053805.1\|WP_174500467.1\|567260_567743_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	1.84903e-12
NZ_CP053805.1\|WP_175231593.1\|569836_570223_-\|NUDIX-hydrolase	gnl\|CDD\|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	1.24713e-18
NZ_CP053805.1\|WP_000982260.1\|568242_568740_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	3.63102e-07
NZ_CP053805.1\|WP_017047369.1\|568900_569224_-\|ion-tolerance-protein-CutA	gnl\|CDD\|225860	COG3323, COG3323, Uncharacterized protein conserved in bacteria [Function unknown].	5.33961e-23
NZ_CP053805.1\|WP_113629352.1\|571656_571866_-\|DUF645-family-protein	gnl\|CDD\|282699	pfam04875, DUF645, Protein of unknown function, DUF645. This family includes several uncharacterized proteins from Vibrio cholerae. There is some doubt regarding the existence of these proteins, they are encoded by open reading frames contained within a repeated region in the Vibrio superintegron.	2.16224e-23
NZ_CP053805.1\|WP_000491261.1\|570909_571299_-\|VOC-family-protein	gnl\|CDD\|319923	cd07262, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.53139e-45
NZ_CP053805.1\|WP_080478885.1\|574982_575093_-\|DUF3265-domain-containing-protein	gnl\|CDD\|288509	pfam11665, DUF3265, Protein of unknown function (DUF3265). This family of proteins with unknown function appear to be restricted to Vibrio.	2.25211e-05
NZ_CP053805.1\|WP_069648548.1\|575089_576628_-\|Retron-type-reverse-transcriptase	gnl\|CDD\|238824	cd01646, RT_Bac_retron_I, RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA branches out from a small ssRNA molecule via a 2'-5'phosphodiester linkage. Bacterial retron RTs produce cDNA corresponding to only a small portion of the retron genome.	5.01208e-21
NZ_CP053805.1\|WP_001258569.1\|574414_574693_+\|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin	gnl\|CDD\|367879	pfam04221, RelB, RelB antitoxin. RelE and RelB form a toxin-antitoxin system. RelE represses translation, probably through binding ribosomes. RelB stably binds RelE, presumably deactivating it.	3.203e-34

>NZ_CP053805.1|WP_000491261.1|570909_571299_-|VOC-family-protein
MFSHIMIGSNDIEKSKVFYDAILSVLGYPAGVIDAKGRCLYINQDGVLGITKPVNGEPATHGNGMTIGFKVSSPELVEAWHAAGLANGGVACEDPPGIRTSGQRKMYLAYLRDPAGNKLCATHHMSTGN
>NZ_CP053805.1|WP_000772125.1|570486_570723_+|hypothetical-protein
MKLLVRNLARTTTEHDIRKLFSEHGSVTECTLVLDQETGLSKGFAFVEMPDASEAKTAIAALNMANVAKSKIRVKAAQ
>NZ_CP053805.1|WP_175231593.1|569836_570223_-|NUDIX-hydrolase
MNHLAMAVVIKNNLVLVQKRFRKNTGMIFEFPGGFIDAGESGEQAAIRELWEETGLRNLELIGTHKSINENGGDIYHVVFSASMDAEPKEIEPYRQQTFYWFEASQIPLNDFYNADVNFIMEHLGSYT
>NZ_CP053805.1|WP_043993102.1|569381_569666_-|antibiotic-biosynthesis-monooxygenase
MSKVILKGFIVVPKAELTMVINELDNHVRLTRLEDGCLIFEVTQNEENPYRFDVYEEFRDQAAFDKHQLRVKSSTWGKVSTNVERNYEVMVSCA
>NZ_CP053805.1|WP_017047369.1|568900_569224_-|ion-tolerance-protein-CutA
MYKLEIFCQPNQQDIVLSTLHDAGVDKIGNYDHCWALGSVMGSHRALEGSNPVFGSVGKLENYPLVKIEINVAHENVKPVVQRLKACLGWEEPLINIVKLYNSDFEL
>NZ_CP053805.1|WP_000982260.1|568242_568740_+|GNAT-family-N-acetyltransferase
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQSSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADIRASLG
>NZ_CP053805.1|WP_001915058.1|567973_568246_+|DUF1778-domain-containing-protein
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKLASERYESKTQ
>NZ_CP053805.1|WP_174500467.1|567260_567743_-|GNAT-family-N-acetyltransferase
MELQQLNQRHLKCLLDHVGLDSELTFCEGAVPPKHVLIRSYEQLQNSKAEIWSLPYMMSVDNNVVGFCGFKDEPQDGEVEIGYNVSPYKQGRGFAKLAVNQLCQLAFNVDSIESFVALISSANLASLNVVRANHFVFIGFVVDSDNEKLEKWVLQRASCT
>NZ_CP053805.1|WP_175231591.1|566843_567143_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MKPFNLTVAAKADLRDIALFTKRRWGNEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQIRVIRILHKSMDVNPIFGA
>NZ_CP053805.1|WP_001107719.1|566604_566847_+|type-II-toxin-antitoxin-system-ParD-family-antitoxin
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
>NZ_CP053805.1|WP_113629352.1|571656_571866_-|DUF645-family-protein
MKTVTPRCFNVVGCSTRKVWFHKGRIIAESVFSLSRTLNRGQLNLDRFEFWQPTSQLLALDVCLCDAFA
>NZ_CP053805.1|WP_175231595.1|572129_572726_-|class-I-SAM-dependent-methyltransferase
MDKNAEIWRQFYEKALSRPHSKSTEFAVRLNESNLKVATDCGCGTGSDIRYLEQQGFRVHGFDINPDSVAICRDRFGSRSLVNISESSFESFDYPKSGVVIANSSLFFADPNQFETTWRNIKSSIEAGGVFSGDFMGFKDSWAENYRSPTTPLSELEVKGLFSDFEIVRFFERDENAKTSLGRMKHWHTYSVVAVKRT
>NZ_CP053805.1|WP_001232701.1|572873_573191_-|HigA-family-addiction-module-antidote-protein
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWDTRNRYQEEAKFVKPLFVSLEQSART
>NZ_CP053805.1|WP_001162670.1|573201_573489_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQWVDGVALNTYLDPHKY
>NZ_CP053805.1|WP_175231597.1|573529_573652_-|acetyltransferase
MVMVVVFEFSVMRCQPLRRALCTFLKSFLQIKLVHSVTMR
>NZ_CP053805.1|WP_175231599.1|573724_574129_-|hypothetical-protein
MNPTDLNALKPGYRSSKHAKWALKLASYASFVPLTLTLVFHMLVPRGFYDYLEFNEISLIILYATNIAYAVFGFFMLKEKVWAANIAFFLLGGTMIMNYYFDRELPSGFWIALLLLLVNAIRAAYYLKMYPNEL
>NZ_CP053805.1|WP_001258569.1|574414_574693_+|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAMLNELTEGKVKHV
>NZ_CP053805.1|WP_175231601.1|574685_574955_+|type-II-toxin-antitoxin-system-YafQ-family-toxin
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLASIGSHSDLF
>NZ_CP053805.1|WP_080478885.1|574982_575093_-|DUF3265-domain-containing-protein
MTNCSRGIRNAWHIYCALALVFKVLCGGFGIALLTP
>NZ_CP053805.1|WP_069648548.1|575089_576628_-|Retron-type-reverse-transcriptase
MAITKDSIEWAIDFLVDHSDGDLFPRILELQAISEQKSDFINQVENKPLNQLAPMPCRRFIVPKDELSYRQATQLHPQDSIILSALMHQFGQGIEDRRLDKSKVYSYRFLPTKDHGLYEEKAAWNEFWTEAHNKSKNYNAVLYCDIADFYNQIYHHTVENQLISSNFSNQAVKWVISLLESTTAGVSRGVPIGPHGIHLIAESTLIPVDNSLEANGLVFQRYADDILIFCESEKSAKKALSLLASILDRQQRLMLQKHKTKIYTPSDFQHLCTEMIEDRPISNEEEKLLGIIRKYTGGNPYKTISYSQIQPTDWANFSSTVVSKIIQDYLSKSDVDYIRLRWFYRRLTQVGHPGAIDLSISEFESLGPCLANICTYISSIQSISPTDWKTVGDKLLELLGTDEIQQSEFFRLSILSLFTKNEHINHFSSLAKKFQSSDPFARREILLAATRNHAFDWLREHKEGYTHMDPWQKIAFIYAVSGLPQDEKKYFISRCSFNGPFEETLAKWSKRI

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

448956 : 457999

Vibrio_phage(90.91%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000164568.1\|448956_449313_+	phage protein	G8IRV3	Vibrio_phage	1.7e-61	94.9
WP_175231875.1\|449332_449443_-	DUF3265 domain-containing protein	NA	NA	NA	NA
WP_175231495.1\|449445_450756_-	deoxyguanosinetriphosphate triphosphohydrolase family protein	NA	NA	NA	NA
WP_175231498.1\|451751_453119_-	toxin	Q64EV0	Vibrio_phage	3.6e-216	81.6
WP_001160097.1\|453121_453466_-	DUF2523 domain-containing protein	Q64EV1	Vibrio_phage	1.0e-55	90.4
WP_175231501.1\|453465_454884_-	hypothetical protein	G8IRU9	Vibrio_phage	3.3e-140	69.8
WP_174500057.1\|455017_455227_-	hypothetical protein	G8IRU8	Vibrio_phage	8.3e-16	63.8
WP_000063788.1\|455260_455491_-	hypothetical protein	G8IRU7	Vibrio_phage	4.7e-28	76.0
WP_174500055.1\|455500_455839_-	DUF1293 domain-containing protein	Q858R2	Vibrio_phage	1.6e-56	97.3
WP_001112192.1\|455843_456947_-	replication initiation factor domain-containing protein	Q64EV8	Vibrio_phage	1.5e-220	100.0
WP_000502184.1\|456936_457140_-	hypothetical protein	C3W4P3	Vibrio_phage	2.7e-35	100.0
WP_175231504.1\|457150_457399_-	hypothetical protein	O56843	Vibrio_virus	1.5e-32	85.4
WP_114808200.1\|457630_457999_+	hypothetical protein	G8IRV4	Vibrio_phage	1.8e-58	95.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP053804

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP053805

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection