CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NZ_CP053818	Vibrio cholerae strain SA7G plasmid pSA7G1, complete sequence	0 crisprs	NA	0	0
NZ_CP053817	Vibrio cholerae strain SA7G chromosome 2, complete sequence	1 crisprs	csa3,cas3HD,cas3	0	0
NZ_CP053816	Vibrio cholerae strain SA7G chromosome 1, complete sequence	2 crisprs	cas3,DEDDh,DinG,csx1,csa3,PrimPol	1	6
NZ_CP053819	Vibrio cholerae strain SA7G plasmid pSA7G2, complete sequence	0 crisprs	NA	0	6

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP053817_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053817_1

382698-382786

Orphan

I-F

Consensus_repeat	Method
GTTCACTGCCGCACAGGCAGCTTAGAAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP053817_1

>merge|NZ_CP053817|1|382698-382786|CRISPRCasFinder
GTTCACTGCCGCACAGGCAGCTTAGAAAAATCCCAGAATGTCATCACGCACGGGTACGATGTTCACTGCCGCACAGGCAGCTTAAAAAT

>NZ_CP053817|1|1|382698-382786|CRISPRCasFinder
GTTCACTGCCGCACAGGCAGCTTAGAAAA	ATCCCAGAATGTCATCACGCACGGGTACGAT
GTTCACTGCCGCACAGGCAGCTTAAAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053817.1\|WP_000643598.1\|388947_389193_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372110
NZ_CP053817.1\|WP_175247661.1\|380361_380478_+\|acetyltransferase	unknown	unknown	unknown
NZ_CP053817.1\|WP_029628683.1\|379921_380305_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053817.1\|WP_175246445.1\|387994_388132_+\|DUF3265-domain-containing-protein	unknown	unknown	gnl\|CDD\|288509
NZ_CP053817.1\|WP_172779930.1\|384092_384530_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240022
NZ_CP053817.1\|WP_175247665.1\|388170_388518_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053817.1\|WP_175247663.1\|381961_382387_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053817.1\|WP_175247605.1\|377034_377211_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053817.1\|WP_071180248.1\|379532_379715_+\|DUF645-family-protein	unknown	unknown	gnl\|CDD\|282699
NZ_CP053817.1\|WP_175247606.1\|384679_385618_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053817.1\|WP_002045689.1\|375977_376778_+\|PhzF-family-phenazine-biosynthesis-protein	unknown	unknown	gnl\|CDD\|223461
NZ_CP053817.1\|WP_071179907.1\|383604_383952_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053817.1\|WP_175247658.1\|377250_378171_-\|IS5-family-transposase	unknown	unknown	gnl\|CDD\|290455
NZ_CP053817.1\|WP_175247782.1\|380444_381701_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223021
NZ_CP053817.1\|WP_000589156.1\|388694_388961_+\|BrnT-family-toxin	unknown	unknown	gnl\|CDD\|225481
NZ_CP053817.1\|WP_084981860.1\|378887_379232_+\|regulator-of-ribonuclease-activity-A	unknown	unknown	unknown
NZ_CP053817.1\|WP_175247664.1\|383088_383349_+\|DUF3709-domain-containing-protein	unknown	unknown	gnl\|CDD\|289275
NZ_CP053817.1\|WP_076008659.1\|381704_381815_+\|DUF3265-domain-containing-protein	unknown	unknown	gnl\|CDD\|288509
NZ_CP053817.1\|WP_025613414.1\|387614_388025_+\|cytidine-deaminase	unknown	unknown	gnl\|CDD\|236225
NZ_CP053817.1\|WP_001175917.1\|386280_386982_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP053817.1\|WP_000643598.1\|388947_389193_+\|hypothetical-protein	gnl\|CDD\|372110	pfam12441, CopG_antitoxin, CopG antitoxin of type II toxin-antitoxin system. CopG antitoxin is a member of a type II toxin-antitoxin system family found in bacteria and archaea. Most antitoxins encoded by the relBE and parDE loci belong to the MetJ/Arc/CopG family of dimeric proteins which bind DNA through N-terminal ribbon-helix-helix (RHH) motifs. The toxin for CopG proteins falls into the family BrnT_toxin, pfam04365.	0.00366678
NZ_CP053817.1\|WP_175247658.1\|377250_378171_-\|IS5-family-transposase	gnl\|CDD\|290455	pfam13737, DDE_Tnp_1_5, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	5.69342e-55
NZ_CP053817.1\|WP_175247782.1\|380444_381701_+\|hypothetical-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	1.67425e-28
NZ_CP053817.1\|WP_000589156.1\|388694_388961_+\|BrnT-family-toxin	gnl\|CDD\|225481	COG2929, COG2929, Uncharacterized protein conserved in bacteria [Function unknown].	4.81719e-33
NZ_CP053817.1\|WP_175246445.1\|387994_388132_+\|DUF3265-domain-containing-protein	gnl\|CDD\|288509	pfam11665, DUF3265, Protein of unknown function (DUF3265). This family of proteins with unknown function appear to be restricted to Vibrio.	8.48946e-08
NZ_CP053817.1\|WP_076008659.1\|381704_381815_+\|DUF3265-domain-containing-protein	gnl\|CDD\|288509	pfam11665, DUF3265, Protein of unknown function (DUF3265). This family of proteins with unknown function appear to be restricted to Vibrio.	0.000340399
NZ_CP053817.1\|WP_175247664.1\|383088_383349_+\|DUF3709-domain-containing-protein	gnl\|CDD\|289275	pfam12493, DUF3709, Protein of unknown function (DUF3709). This domain family is found in bacteria, and is approximately 30 amino acids in length. There are two conserved sequence motifs: RCLMK and LIEL.	3.62337e-10
NZ_CP053817.1\|WP_071180248.1\|379532_379715_+\|DUF645-family-protein	gnl\|CDD\|282699	pfam04875, DUF645, Protein of unknown function, DUF645. This family includes several uncharacterized proteins from Vibrio cholerae. There is some doubt regarding the existence of these proteins, they are encoded by open reading frames contained within a repeated region in the Vibrio superintegron.	1.80439e-28
NZ_CP053817.1\|WP_025613414.1\|387614_388025_+\|cytidine-deaminase	gnl\|CDD\|236225	PRK08298, PRK08298, cytidine deaminase; Validated.	4.0651e-62
NZ_CP053817.1\|WP_172779930.1\|384092_384530_+\|NUDIX-domain-containing-protein	gnl\|CDD\|240022	cd04664, Nudix_Hydrolase_7, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	4.53702e-37
NZ_CP053817.1\|WP_002045689.1\|375977_376778_+\|PhzF-family-phenazine-biosynthesis-protein	gnl\|CDD\|223461	COG0384, COG0384, Predicted epimerase, PhzC/PhzF homolog [General function prediction only].	2.17343e-68

>NZ_CP053817.1|WP_175247663.1|381961_382387_+|hypothetical-protein
MEKSNEKVQLLVNAIRFRKPYTANDFQVTAAELKVKKESYHLSKIKSIELKRLGFKDNVVKVTTYAILLSAATWAFVPEFGFFALLIALILALVSMRKYELKVEFKGTDETGDYWVSIARCWTEDEFHILENIYTELKSRI
>NZ_CP053817.1|WP_076008659.1|381704_381815_+|DUF3265-domain-containing-protein
MTNGSRGTANAWHFYHALVFVVTVLCGSLVMALAAP
>NZ_CP053817.1|WP_175247782.1|380444_381701_+|hypothetical-protein
MDKKKIHQEVLDKQKILEESIKNGDHEAVLVDFNSYLDSFVLIGHYNHSTWDVSWTRKCWEFFTELSRYDYSPSFIGVVDDRLLTSSSSEVEALHFIKIELIWNVTGNAKLVESEAKRLVDKYPYNIEFLHALAHVLIKMDGDEKFEAIKCYRKCIEAWGGKFKELIKSTYNYEMSIFKKTLEKGDYLKAEKQIDYIYSFSAYKKDPFFNNSTIMFRERLHDRKYTEALAVKIEREVKESIKKEYEAQSKKNVEILGVFSAVITFIITAAASSFNSDKANTPLILISIGLILILFISTLSLFNDRNVKILNDFRFYILILFAFLTTYSVVTFKSKENLDTYSIVEKTAQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQK
>NZ_CP053817.1|WP_175247661.1|380361_380478_+|acetyltransferase
MVTVVVIEFGVMRCQPLRRALYFIREFIWTRKKYIKKY
>NZ_CP053817.1|WP_029628683.1|379921_380305_+|hypothetical-protein
MDILTALKNVEALANGIDPISGEVLPESSPYNNPEVIRSLFTVIDAVKQPKKGKKSVEQKQEENISKGLPKNAGLPWSEEERENLANAFNAETSIDELSEIHGRTNGAIISELKKQGLIEEFEATSI
>NZ_CP053817.1|WP_071180248.1|379532_379715_+|DUF645-family-protein
MLSDVQHGQFGFTKGSIIAVFWFSLSRTLNRGQLNLDRFEFCLPTSQLLVLDVRLFYAFA
>NZ_CP053817.1|WP_084981860.1|378887_379232_+|regulator-of-ribonuclease-activity-A
MNEYYERKLKQAKRTKSTMPYLGIHLGPTLKPCAVHAKNRNLVLPVDHSYWLDFPMRDSEDCKCSIRQISKHEYQKLKNEGIREQLTAPILNENGKFTGHKEVVFVPINETPVE
>NZ_CP053817.1|WP_175247658.1|377250_378171_-|IS5-family-transposase
MPKPRYKTTNWKQYNKALINRGSLTFWIDEEAIRQWKQSKQDKRGRPRQFSDLAITTALMVKRVFSMPLRALQGFIDSVFSLANVPIVCPHYSCISRRAKQVEVSFKPKSRGAIQHLAIDATGLKVYGEGEWKVKKHGTDGKRRVWRKLHLAVDTSTHEIVAAELSLSNVTDAEVLPNLLKQTRRRIIEISGDGAYDTRDCYDAIRFKRAVPLIPPREGAAFWENGHPRNLAVGCQKLYGSNNKWKKRYGYHKRSLSETAMHRVKQLLGGRLSLRNYNAQVGETYAMIKALNKLTGLGMPETKCVV
>NZ_CP053817.1|WP_175247605.1|377034_377211_+|hypothetical-protein
MEKSNEKVQWLVNAIRFRKPYTANDFQVTASELKVKKESYHLSKIKSIELKRLGGFVA
>NZ_CP053817.1|WP_002045689.1|375977_376778_+|PhzF-family-phenazine-biosynthesis-protein
MEVSIFQVDSFTSEVFKGNPAGVCITETSLDEATMRAIAAEMAVSETAFLSLSTMQLRWFTPEIEVSLCGHGTLAVAHVLKEQGIYKTGDVLEFKTLSGILTAHLDENSIHLVFPTPMLDMKVSPNIDMLNFLGLAQSNLIAYGQFDNKQIIVIDNESLLNDLSPDFSGLSKLKGRGVLVTAKSDSGVDFVSRYFAPWVGVNEDPVTGSAHCALCVYWSKRLGKFQLKGYQASKRGGFVDVELLNPNQVKLSGQAVTVLSGRMKIA
>NZ_CP053817.1|WP_175247664.1|383088_383349_+|DUF3709-domain-containing-protein
MLSLHEVSFALSSRFEQFGAFTYGLKVCQQLSIVFRCLMKRQCVCRCKFQCHCLIELLRPCVVSEFVGEVFHIGLVAKWKPVLVSS
>NZ_CP053817.1|WP_071179907.1|383604_383952_+|hypothetical-protein
MLNLLRFFLISNLTASVVVVMFEKSTGFFGLRSWPDYAFFVVVILWGLAALFCMYPPEGGFGGDRAESVAGSMVDSSVANEIDSERFSSNTMLCIKLFVSGLPAFLTFIIVSTAT
>NZ_CP053817.1|WP_172779930.1|384092_384530_+|NUDIX-domain-containing-protein
MRAPFQVLVFPYQILEQQPRYLIGQRSDNGVWQAISGGGEDSESILEAAKRELQEETSLIGCDWQQLDSMCMLPKVYYADHENWTNHRFVVPEYSFSVRVSAEPQLSNEHTNFRWCCFQEASELLKYDSNKIALWELDQRLKSTL
>NZ_CP053817.1|WP_175247606.1|384679_385618_+|hypothetical-protein
MSRKRGIIFCPHFENIDGDAYIPHVQLRKEQLQSFCLYWDYIVQPVSAELPRWKRRVDEIVLEDAGILLKDYQDLPLARYIYTEESAYSLKSDGAKNWVDTFLDFQAQSLKKNSINQPDVIWVPQQSYREFIAKKKDAIDEHCVQVALYNKLPIPAENISLKKIVAFKSEHSDVLSEFRNSMYLVTLQVSLPTGFSEIALNLAISDLEKIINEITALSRSRFGRSIKFTDLKINIGSQNVTTLLSEFVKGASLSGGISLNPLTAIFGGLACSAASMVQLKPIKSKKLKVIPEEQVEFSYLTEAFVRGVTQRI
>NZ_CP053817.1|WP_001175917.1|386280_386982_+|hypothetical-protein
MQLGDVMLVRGEGPISAGLQAVQQVIHPGTRSSHVLFCLSDGCFIHATGDGGVHLKFVLDELNEVKENWRVIRLRHLPASKRDALSLAGFYFLDQAYNHKFLISGSPHKAFCSELVGKIFQRANIPIMGNKLPHRLTPAHFDREADKQIMWEDVTDECKAYLSSHEHLEDEHRLVFNTLERSLHRNKFLAERKAEVWNLLEAFDPEMYSKIKPVLDEASQKARVKFWNQEDRN
>NZ_CP053817.1|WP_025613414.1|387614_388025_+|cytidine-deaminase
MDNIEKELYQAAIELVNMRYPSGWGGAAAVRTESGKILTSIAPDTKNDALSLCMEVGAYLEAHKLNERVTHSLCLCRENENDEFLILSPCGVCQERLVHWGGDVKAAITTPENALVFKTIRELMPHHWSLVNGKAL
>NZ_CP053817.1|WP_175246445.1|387994_388132_+|DUF3265-domain-containing-protein
MVTCKRQSAITNCLRGIRNAWHFYYALIFLIKVVCGGIGIALLTS
>NZ_CP053817.1|WP_175247665.1|388170_388518_+|hypothetical-protein
MLNLLRFFLISNLTASAVVVMFEKSTGFFGLRSWPDYAFFVVVLLWGLAALFFMYPPEGGFGGDRAESVAGSMVDSSVANEIDSERFSSNTMLCIKLFVSGLPAFLTCIIVSIAT
>NZ_CP053817.1|WP_000589156.1|388694_388961_+|BrnT-family-toxin
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKAEVSLYESA
>NZ_CP053817.1|WP_000643598.1|388947_389193_+|hypothetical-protein
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSVR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP053816_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053816_1

2567059-2567302

Orphan

Consensus_repeat	Method
AAAATGTGCCTCCTTAGCTCAGTCGGTAGAGCAACGGACTGATAATCCG	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP053816_1

>merge|NZ_CP053816|1|2567059-2567302|PILER-CR
TGTGCCGGCTTAGCTCAGTAGGTAGAGCAACTGACTTGTAATCAGTAGGTCGCCAGTTCGATTCCGGCAGCCGGCACCACTTAAAATTTGCCTCGATAGCTCAGTCGGTAGAGCAGAGGATTGAAAATCCTCGTGTCGGTGGTTCGATTCCGCCTCGAGGCACCACTATTAAAAGTTGTGCCATAGACACAATAAAAATTGTTCCTCCTTAGCTCAGTCGGTAGAGCGACGGACTGTTAATCCG

>NZ_CP053816|1|1|2567059-2567302|PILER-CR
TGTGCCGGCTTAGCTCAGTAGGTAGAGCAACTGACTTGTAATCAGTAGG	TCGCCAGTTCGATTCCGGCAGCCGGCACCACTTAAAA
TTTGCCTCGATAGCTCAGTCGGTAGAGCAGAGGATTGAAAATCCTCGTG	TCGGTGGTTCGATTCCGCCTCGAGGCACCACTATTAAAAGTTGTGCCATAGACACAATAAAAAT
TGTTCCTCCTTAGCTCAGTCGGTAGAGCGACGGACTGTTAATCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053816.1\|WP_069731232.1\|2559956_2560388_+\|DUF4426-domain-containing-protein	unknown	unknown	gnl\|CDD\|379616
NZ_CP053816.1\|WP_175246228.1\|2562261_2563182_-\|glutaminase-B	unknown	unknown	gnl\|CDD\|234880
NZ_CP053816.1\|WP_000780522.1\|2573683_2574979_+\|peptidylprolyl-isomerase-SurA	unknown	unknown	gnl\|CDD\|236758
NZ_CP053816.1\|WP_000095775.1\|2574968_2575961_+\|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA	unknown	unknown	gnl\|CDD\|234696
NZ_CP053816.1\|WP_000005583.1\|2563292_2564012_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NZ_CP053816.1\|WP_001243262.1\|2575974_2576790_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	unknown	unknown	gnl\|CDD\|234708
NZ_CP053816.1\|WP_114812678.1\|2565700_2566828_+\|membrane-bound-lytic-murein-transglycosylase-MltC	unknown	unknown	gnl\|CDD\|183271
NZ_CP053816.1\|WP_071180449.1\|2567594_2569220_+\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910
NZ_CP053816.1\|WP_000383338.1\|2576861_2577242_+\|Co2+/Mg2+-efflux-protein-ApaG	unknown	unknown	gnl\|CDD\|180098
NZ_CP053816.1\|WP_033930630.1\|2560457_2561060_+\|XTP/dITP-diphosphatase	unknown	unknown	gnl\|CDD\|234648
NZ_CP053816.1\|WP_175246231.1\|2577252_2578062_+\|symmetrical-bis(5'-nucleosyl)-tetraphosphatase	unknown	unknown	gnl\|CDD\|234673
NZ_CP053816.1\|WP_000954087.1\|2578721_2579195_-\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|182143
NZ_CP053816.1\|WP_175246229.1\|2564251_2565313_+\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|182805
NZ_CP053816.1\|WP_175246227.1\|2561053_2562229_+\|radical-SAM-family-heme-chaperone-HemW	unknown	unknown	gnl\|CDD\|235550
NZ_CP053816.1\|WP_001087261.1\|2559063_2559621_+\|YggT-family-protein	unknown	unknown	gnl\|CDD\|223833
NZ_CP053816.1\|WP_069647711.1\|2578211_2578709_-\|type-3-dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|365932
NZ_CP053816.1\|WP_000741914.1\|2559620_2559911_+\|YggU-family-protein	unknown	unknown	gnl\|CDD\|179931
NZ_CP053816.1\|WP_000124738.1\|2565326_2565599_+\|oxidative-damage-protection-protein	unknown	unknown	gnl\|CDD\|180059
NZ_CP053816.1\|WP_000546924.1\|2570266_2571121_-\|co-chaperone-DjlA	unknown	unknown	gnl\|CDD\|236512
NZ_CP053816.1\|WP_175246230.1\|2571279_2573631_+\|LPS-assembly-protein-LptD	unknown	unknown	gnl\|CDD\|235158

Protein	Function_ID	Function_description	E-value
NZ_CP053816.1\|WP_069731232.1\|2559956_2560388_+\|DUF4426-domain-containing-protein	gnl\|CDD\|379616	pfam14467, DUF4426, Domain of unknown function (DUF4426). Members of this entry are found mostly in g-proteobacteria, especially in Vibrio. Strangely enough, there seems to be one eukaryotic homolog in Nematostella vectensis (NEMVEDRAFT_v1g226006), where the PA0388-like domain is fused with a domain homogous to the Methionine biosynthesis protein MetW (see below). In several Pseudomonas species, but also in Vibrio vulnificus and Azotobacter vinelandii PA0388 homologs are genomic neighbors of Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) and Methionine biosynthesis protein MetW. On the other hand, in most Vibrio species it appears as a part of a conserved operon involved in possible response to stress.	1.39708e-66
NZ_CP053816.1\|WP_175246228.1\|2562261_2563182_-\|glutaminase-B	gnl\|CDD\|234880	PRK00971, PRK00971, glutaminase; Provisional.	0
NZ_CP053816.1\|WP_000780522.1\|2573683_2574979_+\|peptidylprolyl-isomerase-SurA	gnl\|CDD\|236758	PRK10770, PRK10770, peptidyl-prolyl cis-trans isomerase SurA; Provisional.	1.14348e-156
NZ_CP053816.1\|WP_000095775.1\|2574968_2575961_+\|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA	gnl\|CDD\|234696	PRK00232, pdxA, 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed.	0
NZ_CP053816.1\|WP_000005583.1\|2563292_2564012_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	6.44859e-111
NZ_CP053816.1\|WP_001243262.1\|2575974_2576790_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	gnl\|CDD\|234708	PRK00274, ksgA, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA.	3.27746e-146
NZ_CP053816.1\|WP_114812678.1\|2565700_2566828_+\|membrane-bound-lytic-murein-transglycosylase-MltC	gnl\|CDD\|183271	PRK11671, mltC, membrane-bound lytic murein transglycosylase MltC.	6.18929e-156
NZ_CP053816.1\|WP_071180449.1\|2567594_2569220_+\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	4.37816e-58
NZ_CP053816.1\|WP_000383338.1\|2576861_2577242_+\|Co2+/Mg2+-efflux-protein-ApaG	gnl\|CDD\|180098	PRK05461, apaG, CO2+/MG2+ efflux protein ApaG; Reviewed.	1.16069e-74
NZ_CP053816.1\|WP_033930630.1\|2560457_2561060_+\|XTP/dITP-diphosphatase	gnl\|CDD\|234648	PRK00120, PRK00120, dITP/XTP pyrophosphatase; Reviewed.	1.50746e-127
NZ_CP053816.1\|WP_175246231.1\|2577252_2578062_+\|symmetrical-bis(5'-nucleosyl)-tetraphosphatase	gnl\|CDD\|234673	PRK00166, apaH, symmetrical bis(5'-nucleosyl)-tetraphosphatase.	3.79883e-168
NZ_CP053816.1\|WP_000954087.1\|2578721_2579195_-\|threonine/serine-exporter-family-protein	gnl\|CDD\|182143	PRK09917, PRK09917, threonine/serine exporter.	7.45224e-67
NZ_CP053816.1\|WP_175246229.1\|2564251_2565313_+\|A/G-specific-adenine-glycosylase	gnl\|CDD\|182805	PRK10880, PRK10880, adenine DNA glycosylase.	0
NZ_CP053816.1\|WP_175246227.1\|2561053_2562229_+\|radical-SAM-family-heme-chaperone-HemW	gnl\|CDD\|235550	PRK05660, PRK05660, radical SAM family heme chaperone HemW.	0
NZ_CP053816.1\|WP_001087261.1\|2559063_2559621_+\|YggT-family-protein	gnl\|CDD\|223833	COG0762, COG0762, Predicted integral membrane protein [Function unknown].	2.77868e-12
NZ_CP053816.1\|WP_069647711.1\|2578211_2578709_-\|type-3-dihydrofolate-reductase	gnl\|CDD\|365932	pfam00186, DHFR_1, Dihydrofolate reductase.	3.9817e-90
NZ_CP053816.1\|WP_000741914.1\|2559620_2559911_+\|YggU-family-protein	gnl\|CDD\|179931	PRK05090, PRK05090, hypothetical protein; Validated.	1.27614e-60
NZ_CP053816.1\|WP_000124738.1\|2565326_2565599_+\|oxidative-damage-protection-protein	gnl\|CDD\|180059	PRK05408, PRK05408, oxidative damage protection protein; Provisional.	5.47988e-59
NZ_CP053816.1\|WP_000546924.1\|2570266_2571121_-\|co-chaperone-DjlA	gnl\|CDD\|236512	PRK09430, djlA, co-chaperone DjlA.	1.60415e-153
NZ_CP053816.1\|WP_175246230.1\|2571279_2573631_+\|LPS-assembly-protein-LptD	gnl\|CDD\|235158	PRK03761, PRK03761, LPS assembly outer membrane complex protein LptD; Provisional.	0

>NZ_CP053816.1|WP_114812678.1|2565700_2566828_+|membrane-bound-lytic-murein-transglycosylase-MltC
MRKLVLCITTLLLSGCSREFIEKIYDVDYEPTNRFAKNLAELPGQFQKDTAALDALINSFSGNIEKRWGRRELKIAGKNNYVKYIDNYLSRSEVNFTEGRILVETVSPIDPKAHLRNAIITTLLTPDDPAHVDLFSSKDIELKGQPFLYQQVLDQDGQPIQWSWRANRYADYLIANHLKVKQVDFKKAYYVEIPMVKDQIDIRGYKYASIVRKASRKYDIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAGRDVFKLVKNRSGEPSPEYLFNPENNIDTGTAYFYILKNRYLKEVRHPTSLEYSMISAYNGGTGGVLSTFSSDRQRAMRDLNALQPNQVYWALTKKHPNAEARRYLEKVTKFKKEFNAG
>NZ_CP053816.1|WP_000124738.1|2565326_2565599_+|oxidative-damage-protection-protein
MARTVFCTRLQKEADGLDFQLYPGELGKRIFDNICKEAWAQWQTKQTMLINEKKLNMMDPEHRKLLEQEMVNFLFEGKEVHIEGYTPPAK
>NZ_CP053816.1|WP_175246229.1|2564251_2565313_+|A/G-specific-adenine-glycosylase
MTPFAQAILTWYDAYGRKNLPWQQNKNAYRVWLSEIMLQQTQVATVIPYFERFLERFPTVQALAAAPQDEVLHFWTGLGYYARARNLHKTAQMVVSEYGGEFPTDLEQMNALPGVGRSTAAAVLSSVYKKPHAILDGNVKRTLARCFAVEGWPGQKNVENQLWHYAEMHTPKVDVDKYNQAMMDMGAMICTRSKPKCSLCPVESFCLAKQQGNPQEYPGKKPKTDKPVKATWFVMLYHDNAVWLEQRPQSGIWGGLYCFPQSEIANIQTTIDQRAIGDSTITSQKTLIAFRHTFSHYHLDITPILLQLSRKPDIVMEGSKGLWYNLSQPDEIGLAAPVKQLLHSLPFDIDSHI
>NZ_CP053816.1|WP_000005583.1|2563292_2564012_-|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MSEVITQEYTEDGKVLRRIRSFVRREGRLTKGQEAAMKECWPTMGIDYQPELLDWQQVFGNDNPVVLEIGFGMGASLVEMAKNAPEKNFLGIEVHSPGVGACLASAREAGVTNLRVMCHDAVEVFAHMIPDNSLHTLQLFFPDPWHKKRHHKRRIVQLEFAEMVRQKLIIGSGVFHMATDWENYAEHMVEVMNQAPGFANLATDGDYIPRPDERPLTKFEQRGHRLGHGVWDIKYQRTA
>NZ_CP053816.1|WP_175246228.1|2562261_2563182_-|glutaminase-B
MKPTAEILASIIEEVRPLTSKGIVADYIPALAKVPSEKLGIAVFTNQGEVITAGDAQEGFSIQSISKVLSLTLAMGLYQPDELWSRVGKEPSGQAFNSLIQLEMEHGIPRNPFINAGAIVVCDMLQSRLSAPRQRLLEFVRQLSGEPQIAYDKVVAASEMMHSDRNAAIAYLMRSFGNFHNEVIPVLHNYFHACALKMSCVELAKTFSYLANKGVSVVTGETVITPTQSKQTNALLATCGLYDGAGEFAYRVGMPGKSGVGGGIIAVVPGEMTIAVWSPALDQSGNSLAGTRALELLAQRIGRSIF
>NZ_CP053816.1|WP_175246227.1|2561053_2562229_+|radical-SAM-family-heme-chaperone-HemW
MLTPPPLSLYIHIPWCVQKCPYCDFNSHAQKGDIPEQEYLDALLEDLDRDIERYQLKGDPRLLHSIFIGGGTPSLISAEGIARLLQGVAERIVFKPDIEITMEANPGTIEAQRFAGYRTAGVTRISIGVQSFEPEKLARLGRIHGQQEAVRAAQLAHKIGLNSFNLDLMHGLPDQTPEQALADLDQAIVLNPPHLSWYQLTIEPNTLFYSKPPKLPDEDALWDIFELGHQKLSDAGYVQYEISGYSKLGYQCQHNLNYWRFGDYLGIGCGAHGKLSFADGRIVRTTKTKHPRGYLAALNNLAKAYLDSEQLVADQDKPFEFFMNRFRLIEPCPKADFTATTGLTIDVIRPTLDWALSEGYLSEDDQHWQITEKGKLFLNDLLEAFMADEEE
>NZ_CP053816.1|WP_033930630.1|2560457_2561060_+|XTP/dITP-diphosphatase
MKKIVLATGNQGKVREMADLLSDFGFDVIAQSEFNVPEAAETGTTFIENAIIKARHAAQITGLPAIADDSGLEVDYLNGAPGIYSARYAGEHASDGDNLNKLLAAMQDVPDDQRSARFHCVLVLMRHADDPTPIVCHGKWEGKILTAPHGSNGFGYDPIFWVPEENCASAELEPVRKKQLSHRGKALQKLFKAIEEQRKC
>NZ_CP053816.1|WP_069731232.1|2559956_2560388_+|DUF4426-domain-containing-protein
MRKWIMSLLLTLLALPASAEQQKTIKDIEVHYSAFNSTFLTPKVASSYQLTRNGYTAILNISVLDRASLGKPATEAKLTGHAKNLIGNLRELSFKQVKEGNAIYYLAEVPISNEEMLTFDIDVDAGLKGAGKLTFSQKFYTEQ
>NZ_CP053816.1|WP_000741914.1|2559620_2559911_+|YggU-family-protein
MAAVWREGDDLLLRLYIQPKASRDSIVGLHGEELKVAITAPPIDGKANAHLSKYLAKLCKVAKGSVVIEKGELGRHKQVRILQPSQIPAEIAALIE
>NZ_CP053816.1|WP_001087261.1|2559063_2559621_+|YggT-family-protein
MNSLSFLINTLFDLYIMVVILRIWLQAARADFYNPFSQFIVKATQPVVGPLRRVIPSIGSIDLATIVFAYVLCVLKFMALVLIASSGSVSFSADFLFLGLLSLIKAAGGLLFWVLLIRAILSWVSQGRSPIEYVFHQLTEPMLAPIRRIIPVMGGFDLSILVLFIVLQFANFLMGDVIGPIWYQL
>NZ_CP053816.1|WP_071180449.1|2567594_2569220_+|methyl-accepting-chemotaxis-protein
MKLKTQAYLLSAIILAALLALTATGLWTLRVASNLDNKARVTELFNSAYSILTEVEKLAQEGKMSEPEAKALATRLMRNNLYKDNEYVYVADENMTFVATPLDPQLHDTSFHDFKDGKGNSIGRLIQDVLRHQSGKLVEYTWTQKQADGSIEEKLSIARKTPHWGWVVGTGIGFNEVNARFWSTAQWQLSLCVVIAFAILSLLLVAIRKILLIIGGEPNEVRSAVQAVAQGRIRREFAIKAPKESIYGAVQQMSSSLADLVAKLEQSMVALRSELAGAGTRAKSIAELTDSQQQSTAMIATAMTEMASSANQVADSARDTAFNTDQADQQSQHTQKLIHNTVSNIQGLATQLQTASTAVADLDLDVKNIAKVLDVIGDIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRNLAGRTQTSTKEIQQMIHNLQEGSRNAIQTIQICGQTSQSSVQESENAASALALIVSALESVSSMSHQIATAAAEQTQVSDDIARRINMIEESGSKLSRVVMESHNSTQTLTKLARELEQWAAHFEVTR
>NZ_CP053816.1|WP_000546924.1|2570266_2571121_-|co-chaperone-DjlA
MHIFGKILGAFFGFLFGGPFGAIFGIFLGHQFDKARRLNQAGFQSGTFGAGPSQAERQEEFFKSAFSVMGHVAKAKGQVTKEEIQLATIMMDRMNLTLEQKRAAQDAFRDGKESDFPLEQVLERVKIATGGRFDLLQFFLELQVSSAFADGDVHPSERQVLHRIARGLGFSSEQLERRLRMQEAAFRFQQGGGFGGSQQQSHSGQQWQQPSSRHQLADAYEVLGVSESASAQEVKRAYRKLMNEHHPDKLMAKGLPPEMMNVAKEKSQQIQHAYELIRKEKGIK
>NZ_CP053816.1|WP_175246230.1|2571279_2573631_+|LPS-assembly-protein-LptD
MSCFSRTFLAASISAALFAPQIQAEASVDDNRAQLPNGEQCLVNQPEPTNPGQQPINVEADKLEAINGQKATYSGNVVVVQGKKRIAADNVTLHQQENVVVAEGNVQFSDGEIKTHSTKATNHLNTDEMTLENTRYQFLCEPGRGEAVYVSKTGKAVYEIEDGSITSCPDGDNAWRMRASSIDVDQNEEIATFYNPRLEVQNVPVFYLPYLTVPIGDTRKTGFLYPTASYGSRNGYSFEVPIYWNLAPQYDLETTFNYMQKRGTQLNSVFRYLTDFGAGQIKSEYLTDDQLHTELGDRWAFQYEHNGIFQQAWKFEIDYSKVSDINYFSDLDSGVGNREDGQLIQEGRATYRSDNWDSALLVRDFQLLTKDTTSTNLPYRLMPQLSYNYYAPETMKYLDLDLVSHISRFETDARGKPSATRVHIEPGLKIPFSNTWGNWTTEARVLGTYYQQDLDKTTDAKLEESVTRVIPEIRSVAGIVLERDTVLLDDYTQTLEPKIQYLYVPEKYQDNIGLYDSTLLQTDYYGLFRSRKYSGVDRIESANQVSYGASTRFFDSNYKERLNIAFGQIFYLDSKLNPSNKNPDSTSDKTSYSAWAVEMDFNFADYLFYHGGIQYDIDSQAVQLGNSTLEYRVASGYIQANYRYVAKDYIRNTVGDSITNIDDITRDGISQAGILAGYQLSRKWSASGQYYYDLTTDEALEWLANLTYTSDCWYVGFTYSNQLKSWNGNFVTDPYATPIYENNFSFNIGIIGFGTSIGAGSSMTGVDSAGNSLGYGRPFFLNN
>NZ_CP053816.1|WP_000780522.1|2573683_2574979_+|peptidylprolyl-isomerase-SurA
MKLWKPTLISVLSALTLFNAHAEPKQLDSVAVIVNSGVILQSDVDSALKTIKANAKQNKQPLPQETVLREQVLEKLIIDTLQQQEADRIGVKIDDNRLNEAIKEIAKNNQQTQEQLIASVAQEGLTYPEFREQVRKEMAASDARNALVRRRINILPAEVDTLAELLAQETDATVQYKISHIQLRVDDGQDKSAAETLANKLVNDLRNGADFAQMAYAYSKGPKALQGGDWGWMRKEEMPTIFADQIKMQNKGSIIGPFRSGVGFHILKIDDVKGLETVAVTEVNARHILIKPTIILSDEGAQKQLNEFVQRIKNGEVTFAELAQQYSQDPGSAAQKGELGYQTPDLYVPEFKHQIETLPVGQISEPFKTVHGWHIVEVLDRREVDRTDSALKNKAYRILFNRKFNEEASAWLQELRASAFVEVLKDEKDEQ
>NZ_CP053816.1|WP_000095775.1|2574968_2575961_+|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA
MSSKRIIVTAGEPAGIGPDLVLALSAQDWPHQLVVCADKALLAQRATQLGIQVKLLDYQRDNPVQAQQAGTLLVEHISLAEPVVAGQLNPANGHYVLKTLERAAKGCMNGEFDAIVTGPVHKGVINRAGVAFSGHTEFFAEQSKTPLVVMMLATEGLRTALVTTHLPLAEVPQAITCERLEQIVHILHKDLVEKFAIAEPKIYVCGLNPHAGEDGVLGMEEIETITPTLQRLREQYGMQLVGPLPADTIFSEKYLQQADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFIRTSVDHGTALDLAGTGQADAGSFWTALAYAIELVDKKAQ
>NZ_CP053816.1|WP_001243262.1|2575974_2576790_+|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA
MRNDVHLGHKARKRFGQNFLNDPYIIDGIVSAINPKPGQNLVEIGPGLGAITEPVGREVDKFTVIELDRDLAERLRNHPELASKLTIHEGDAMRFDFKQLVKPNNKLRVFGNLPYNISTPLMFHLFEFHRDIQDMHFMLQKEVVNRLAAGPGTKAYGRLTVMAQYYCKVVPVLEVPPSAFVPPPKVDSAVVRLVPYEDLPHPATSLEWLDRVVREGFNQRRKTVRNCYKGLAEPETLETLGINPGMRPENLTLAQFVALANWLDATHKTHA
>NZ_CP053816.1|WP_000383338.1|2576861_2577242_+|Co2+/Mg2+-efflux-protein-ApaG
MDVSLPCIKIQVQTRYIEEQSNPEYQRFVFAYLITIKNLSSQTVQLMSRRWLITDADGKQTVVEGDGVVGEQPRIKANDEYTYSSGTALDTPVGVMQGQYLMIDEQGESFTVEIEPFRLAVPHVLN
>NZ_CP053816.1|WP_175246231.1|2577252_2578062_+|symmetrical-bis(5'-nucleosyl)-tetraphosphatase
MANYIVGDIQGCFDELQQLLKQAEFNSQLDTLWFAGDLVARGPKSLETLRFAYQLGDAARVVLGNHDLHLLSVALGHHSAKRRDQTQVILDAPDAAPLLDWLRQQPLLAEHQEFVLCHAGISPQWDLATARQAAQEVESVLRSPEWSTLIEQMYSDQPDAWHPTLQGIDRLRYIVNAFTRMRFCFPDGRLDMQCKLPPQEVTDGSLLPWFQLPQRIALEKTVIFGHWAALEGYVSETVIGLDTGCVWGGTLTMLRWEDKHYFSQAALPA
>NZ_CP053816.1|WP_069647711.1|2578211_2578709_-|type-3-dihydrofolate-reductase
MMISMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVVMGRKTYQSIGRPLPGRHNIVISRDASLQIEGGDVVTSIEAALVKAGEVDEVMIIGGGSLYAACLPMAHKLYITEIHAKLEGDTQFPEWGSDWLERSREHYPADEKNAYGMDFVIFERQYPLPT
>NZ_CP053816.1|WP_000954087.1|2578721_2579195_-|threonine/serine-exporter-family-protein
MLSWDLFFGLLNDMFFAAIPAVGFALVFNVPVPALKYCALGGALGHGSRYLMMHFGVPIEWASFFAATLVGMVGVYWSRRFLAHPKVFTVAALIPMVPGVFAFKAMIALVEINHVGFSPELMEALLENFLKAMFIIAGLAVGLAVPGLLFYRRKPII

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Crispr_ID: NZ_CP053816_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP053816_2

2995938-2996022

Orphan

Consensus_repeat	Method
CCCCCCCTTGCCACGCATAATTACCCCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP053816_2

>merge|NZ_CP053816|2|2995938-2996022|CRISPRCasFinder
CCCCCCCTTGCCACGCATAATTACCCCCCTGACTACTGACGATCTGCGCATAATCACCCCCCCTTGCCACGCATAATTCCCCCCC

>NZ_CP053816|2|1|2995938-2996022|CRISPRCasFinder
CCCCCCCTTGCCACGCATAATTACCCCCC	TGACTACTGACGATCTGCGCATAATCA
CCCCCCCTTGCCACGCATAATTCCCCCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP053816.1\|WP_063691921.1\|2994887_2995841_+\|replication-protein	unknown	unknown	gnl\|CDD\|309782
NZ_CP053816.1\|WP_000683499.1\|3003526_3004273_-\|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270427
NZ_CP053816.1\|WP_000378235.1\|2999443_3001069_-\|membrane-protein-insertase-YidC	unknown	unknown	gnl\|CDD\|234942
NZ_CP053816.1\|WP_011791301.1\|2983234_2983630_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053816.1\|WP_032481345.1\|2996562_2997786_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271185
NZ_CP053816.1\|WP_063691927.1\|2991133_2991667_+\|regulator	unknown	unknown	gnl\|CDD\|377635
NZ_CP053816.1\|WP_000505208.1\|3002777_3003449_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NZ_CP053816.1\|WP_032481337.1\|2996197_2996566_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|200128
NZ_CP053816.1\|WP_149595617.1\|2997988_2999350_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	unknown	unknown	gnl\|CDD\|235392
NZ_CP053816.1\|WP_000593848.1\|3002043_3002781_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP053816.1\|WP_001747910.1\|2990519_2991131_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053816.1\|WP_154113085.1\|2991763_2994523_+\|conjugal-transfer-mating-pair-stabilization-protein-TraN	unknown	unknown	gnl\|CDD\|237846
NZ_CP053816.1\|WP_113604264.1\|2984727_2986152_+\|conjugal-transfer-protein-TraH	unknown	unknown	gnl\|CDD\|368759
NZ_CP053816.1\|WP_000901446.1\|2982550_2982820_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053816.1\|WP_113604263.1\|2983626_2984484_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053816.1\|WP_000044781.1\|3001664_3001802_-\|50S-ribosomal-protein-L34	unknown	unknown	gnl\|CDD\|366117
NZ_CP053816.1\|WP_001747916.1\|2982287_2982473_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP053816.1\|WP_175246303.1\|2986155_2989560_+\|conjugal-transfer-protein-TraG-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|369594
NZ_CP053816.1\|WP_001884349.1\|3001295_3001652_-\|ribonuclease-P-protein-component	unknown	unknown	gnl\|CDD\|179327
NZ_CP053816.1\|WP_001886301.1\|3001071_3001329_-\|membrane-protein-insertion-efficiency-factor-YidD	unknown	unknown	gnl\|CDD\|376620

Protein	Function_ID	Function_description	E-value
NZ_CP053816.1\|WP_063691921.1\|2994887_2995841_+\|replication-protein	gnl\|CDD\|309782	pfam04796, RepA_C, Plasmid encoded RepA protein. Family of plasmid encoded proteins involved in plasmid replication. The role of RepA in the replication process is not clearly understood.	1.76848e-30
NZ_CP053816.1\|WP_000683499.1\|3003526_3004273_-\|amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270427	cd13709, PBP2_YxeM, Substrate binding domain of an ABC transporter YxeMNO; the type 2 periplasmic binding protein fold. This group contains cystine-binding domain (YxeM) of a periplasmic receptor-dependent ATP-binding cassette transporter and its closely related proteins. Cystine is an oxidized dimeric form of cysteine that is required for optimal bacterial growth. In Bacillus subtilis, three ABC transporters, TcyJKLMN (YtmJKLMN), TcyABC (YckKJI), and YxeMNO are involved in uptake of cystine. Likewise, three uptake systems were identified in Salmonella enterica serovar Typhimurium, while in Escherichia coli, two transport systems seem to be involved in cystine uptake. Moreover, L-cystine limitation was shown to prevent virulence of Neisseria gonorrhoeae; thus, its L-cystine solute receptor (Ngo0372) may be suited as target for an antimicrobial vaccine. The cystine receptor belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.78391e-123
NZ_CP053816.1\|WP_000378235.1\|2999443_3001069_-\|membrane-protein-insertase-YidC	gnl\|CDD\|234942	PRK01318, PRK01318, membrane protein insertase; Provisional.	0
NZ_CP053816.1\|WP_032481345.1\|2996562_2997786_-\|site-specific-integrase	gnl\|CDD\|271185	cd01185, INTN1_C_like, Integrase IntN1 of Bacteroides mobilizable transposon NBU1 and similar proteins, C-terminal catalytic domain. IntN1 is a tyrosine recombinase for the integration and excision of Bacteroides mobilizable transposon NBU1 from the host chromosome. IntN1 does not require strict homology between the recombining sites seen with other tyrosine recombinases. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	3.04278e-51
NZ_CP053816.1\|WP_063691927.1\|2991133_2991667_+\|regulator	gnl\|CDD\|377635	pfam06252, DUF1018, Protein of unknown function (DUF1018). This family consists of several bacterial and phage proteins of unknown function.	0.0020516
NZ_CP053816.1\|WP_000505208.1\|3002777_3003449_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	3.50928e-75
NZ_CP053816.1\|WP_032481337.1\|2996197_2996566_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|200128	TIGR01764, Probable_excisionase, DNA binding domain, excisionase family. An excisionase, or Xis protein, is a small protein that binds and promotes excisive recombination; it is not enzymatically active. This model represents a number of putative excisionases and related proteins from temperate phage, plasmids, and transposons, as well as DNA binding domains of other proteins, such as a DNA modification methylase. This model identifies mostly small proteins and N-terminal regions of large proteins, but some proteins appear to have two copies. This domain appears similar, in both sequence and predicted secondary structure (PSIPRED) to the MerR family of transcriptional regulators (pfam00376). [Unknown function, General].	3.3368e-14
NZ_CP053816.1\|WP_149595617.1\|2997988_2999350_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	gnl\|CDD\|235392	PRK05291, trmE, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE.	0
NZ_CP053816.1\|WP_000593848.1\|3002043_3002781_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	6.92409e-143
NZ_CP053816.1\|WP_154113085.1\|2991763_2994523_+\|conjugal-transfer-mating-pair-stabilization-protein-TraN	gnl\|CDD\|237846	PRK14876, PRK14876, conjugal transfer mating pair stabilization protein TraN; Provisional.	0
NZ_CP053816.1\|WP_113604264.1\|2984727_2986152_+\|conjugal-transfer-protein-TraH	gnl\|CDD\|368759	pfam06122, TraH, Conjugative relaxosome accessory transposon protein. The TraH protein is thought to be a relaxosome accessory component, also necessary for transfer but not for H-pilus synthesis within the conjugative transposon.	3.87993e-98
NZ_CP053816.1\|WP_000044781.1\|3001664_3001802_-\|50S-ribosomal-protein-L34	gnl\|CDD\|366117	pfam00468, Ribosomal_L34, Ribosomal protein L34.	1.21493e-11
NZ_CP053816.1\|WP_001884349.1\|3001295_3001652_-\|ribonuclease-P-protein-component	gnl\|CDD\|179327	PRK01732, rnpA, ribonuclease P; Reviewed.	2.22129e-65
NZ_CP053816.1\|WP_175246303.1\|2986155_2989560_+\|conjugal-transfer-protein-TraG-N-terminal-domain-containing-protein	gnl\|CDD\|369594	pfam07916, TraG_N, TraG-like protein, N-terminal region. The bacterial sequences found in this family are similar to the N-terminal region of the TraG protein. This is a membrane-spanning protein, with three predicted transmembrane segments and two periplasmic regions. TraG protein is known to be essential for DNA transfer in the process of conjugation, with the N-terminal portion being required for F pilus assembly. The protein is thought to interact with the periplasmic domain of TraN to stabilize mating-cell interactions.	1.00951e-56
NZ_CP053816.1\|WP_001886301.1\|3001071_3001329_-\|membrane-protein-insertion-efficiency-factor-YidD	gnl\|CDD\|376620	pfam01809, Haemolytic, Haemolytic domain. This domain has haemolytic activity. It is found in short (73-103 amino acid) proteins and contains three conserved cysteine residues.	5.83497e-39

>NZ_CP053816.1|WP_063691921.1|2994887_2995841_+|replication-protein
MKPFSQLLAQYQADIEVENRDKSQGLSRAESELIDASVRIKSDPPSPNDFTFMHSIMCQVGLPRSRVNGSEFERRCGAAGLYIRAGKIWDGKQFLQQPVPYGPMPRLVMAYLNTQALRSKSPEIDVGNSASAFLKQLGKESSGGKNGSYTNFRKQLLALSACSITLGFSTADKAFTYDGKPIQKFEAWIGNSDNQGALWPGVITFSHEYFTTLSEHAVPLDLRALNQLNSSALAMDIYAMLSDRLHRISGRPVVLYWRNLREQFGQEYTGDDADRNFKKVFLPALKRVLTVYPDAKVKKVTGGILMMSSPPPIPYRN
>NZ_CP053816.1|WP_154113085.1|2991763_2994523_+|conjugal-transfer-mating-pair-stabilization-protein-TraN
MSTMPPIMTRFVASLLCLTISVLPIHSYAGNQEPNIGAVGRDAKQFGLSIANGVKQNSAQVQDGKISLPVGNGQSTSININELFPGVQPGQNTAEYFPDAASPEELEQIFSDADAMDQFGNEAKANLFQDANSSNPSISGSAYQVLMDAANRSRPDFSNDPVLNLSKKTYEDMDLIAGGFGDCSAETTINQNTINAHIPEYERCQRVVDQSADCEVVHDYDASVVKHYDGPYNLKSCGDGCTELWIGKVGDDYWAGNCKIYEEYTRVQVSNPDAIVSATLEYVKWDDYMQVWVGKSGQETKVWSGPDGNFPPETAGRCELSTSWERNPNVDVTPYFKNVKDGDVVTFKIRVSVTGEGEGFGRIKLRYDPSKAITKDEWAPQSCMDSAKGVVDGFAEGEITCIDDPTDATGCTVINGVKVCESQLKPSPFPGIPKLCKKVRVKADYDFYKGQMDCWTDPQGETHCPVNTGGNLNSCQMYEDNPQCGFISSECIDGAEGSSGKCYVFKDTYDCGTDISIPTLEKETTYQCGGPIRCMGDDCLDITKSQSTDFARASALLNAAQFMTQDMSCTGQNDDDNPTGEENVMCSAFAGEAGECKIAVGGVSDCCEKPTNISFADYLNLIMAVPKLDGAVMGLSDGSAVKGAYQVLRDPVMSGWTEITQPFASYIENISGAVDSFLQPVQQFAQEAIGALKEQITKLTSEALGNASATGAAGVPAGAPESMTEQILGQQGAAMLSTVMTVYTVYVVSMVMIQMIWKCEEKEFTMNAKRALNSCTYVGSYCKSKVLGACVEERESYCCFNSPLSRIIQEQVRPQLGLNFGDARTPQCGGIPLDRIADIDWSKVNLDEWLGILQQNGKLPDPASLNLDALTGAGSDFNIDGTRQDASERIMERLEGINVDKIRNDKAREIFPDLDGNGG
>NZ_CP053816.1|WP_063691927.1|2991133_2991667_+|regulator
MSECFTSGSLSRWVKARHMALAGYITKIIILETGLTYKQVRRLYAELEYSGYDVKDKKSRTFRGGATLIHSQTSKIQASLLMQLYSNLGGEKVKRSVDISALNKAFRMYHAIRKEVPGMKGGKWEPFDITDAWCLASELRNGEAMIEHCEQCQCTFFTSINQRTCVECPFCRVSKAA
>NZ_CP053816.1|WP_001747910.1|2990519_2991131_+|hypothetical-protein
MYALEPLERDVIGSFDKFAVQLSEEKPDQDIFEFDLTLWTLLKLLSANAPSQVSNHFSLPEDLVNKLASTPDSYLSQLASGVLLSFKLETDQMEVIDALAGSYDSVICLKNVVDDFDAAYWLLLNKLASRNLDMARQNFGVSSGLASSVAASSNSQLRSLSHRVVIRFSLRFDIGVLDQFLSAALADTTPILLKKIQQSLVWR
>NZ_CP053816.1|WP_175246303.1|2986155_2989560_+|conjugal-transfer-protein-TraG-N-terminal-domain-containing-protein
MDFSIYSVGDAAFLEQIMIAVAMATGTGDFERMVSIGLLIGALIISFQSLFQGAKSWDLHQVFACWLVYAISFGAGVTVTIEDAYNGQVRVVDNVPVGPAAAGSIISSVGFGLTKLFEVAYSPVASVTESKFMDSLELLSKLRNHEMESALWTAWNDSLGGGAVDMKKSLTNYISECTAIKFSLGESNEDQINTENWRTALRFDSQIYGTRLFLSPSGPTDPSCTDGWIQLSQSFETAFNSGLSQQALGYLLSTTDALNATSDALYRLQVTNVAAGDFIKANFLQPIVQRGFAQYYSDMNDPYAQIMLTQAESQRNTQYAAEQSLFVKSIQPLMTLVEGFAYAITPIAAFVMVLGSKGLLLVGKYLQMLIWVQLWLPIMSVINLFIYIMGQQALAKYTTGNLSSFEGVAYAGAEIERWIGIGGMMAAATPVLSLMLVTGSVYAFNSLAQRVGASDTVNEKLMSPDLVDRGSVLSQQPQFNQSRIAGTMTSGGESLVDSINLGSTVSNALSSSSAATAQAQKGFASQLSNSVFSGHGSEQTYSQLQSLGQTLRASDSTQAKSILSAAQNYVTDRGINASHTDAVAGAIAMRASAGVDAGKLAAAFTGPVGAAVNAANPVSMNGSLDVSAQSQSQDSRQQLSSDIDSLSRGLGFTKDDSSALTSDLARQVSTDKGQRFTQSLGEEQRKQLMQSSSDLLSSQQTYQELSQAQQTIGTTSNNNISALADKVLNNWSAGKSLSDGVRQSSPETRDFAQRKAQHYQDLGIDSQRAIVGGQLFAMLNSNSPSEQAIAASAIAKATGGNSGIDFNQPGQSAMLVKDAPRYVSPVENSSALSAPERMSNEQKLLAESGSIGSENSVRDAHEKGIQQLEQSYGTSRNEYLNDRLPALRAQIMASDLAPSTSSALFAGAEGAGRFVQQVVGGAGAAKEGFAESFGQSMSKLAQMTPEQRDQFIEDTKKGDDYVKQEYGLGGFLAVGAANLGRDIIGVGISGFEAGKEWLTGKSDLSEAAQGMSVRERGMFFASALASASEAGAGKAAEFVQQYGDEFRQIAMDTARYDYGLNSQAGAELFAASLMGGDSSRSGELRENLREEVGDNVLADKMAAIIESSAGAGKDQAGGYLAPVSRYLSVAKGGR
>NZ_CP053816.1|WP_113604264.1|2984727_2986152_+|conjugal-transfer-protein-TraH
MRVSPPYIRTLSASCLIIFSVVATHASAEGLQSEMDRLFNEMSNTTRPGIHETQRRGVIAGGRVTTKARIFDENLVSFVPPSWKAGCGGVDLFGGSLSFVNADQIVQLMRAVAANAKGYAFQLALDNVFPDGAKWIENFQKKVQALNQHLGNSCQLAQGIVNDSLSAFDTKLKNDTRTKASTKGLFEDMFSATQETDGQTAIKTLKDNSPQAYQEMIGNIVWKQLKKNSVSSWFQYGDNSLLEAMMSITGAVVIGDLINDPNLAGANNSTNPIVTLPGNRITLGDLISGGSVKVYSCDSDTVNCISAGSELKSVQLRGIGNQMSDLLLGSDSSPGLIYKYANNVGALSSAEIAFVSNLPSSFGSLFRNLAAVSSDTAEQFAQQAQTIIALDITYRFIEEIYRATTIALANSDNAYQQKAVDVLDASRAVVRQEYDQLIVRHGKLSDLMGYYNSLLDVTKKQRLLLAAQASGKKE
>NZ_CP053816.1|WP_113604263.1|2983626_2984484_-|hypothetical-protein
MKMNMSTTVSSATALFAAIMLAGCATTPKSYNSDMSRALNLARVGGIYDQDLRDSEDGQNSYRQSLLMKALNVTSLASSLDAPLRGLNGQQTLMFNTASILTSPDNPSARPSLMAWMPASMAKSSEDAYSNYINLIDNAVAVAAKSMNLDLTKIVESTAPKIDGNPLIMWAVTAPQFGCDGSNCVIAYNVTMPNPWKTPAFVGSGIIDSFNLAANNTTKYSRLIFTQVSDVKSFPMDDFYKSTSRALPEWAVMYFPPNSVFQDGKALPYPVIYEKGQQLLFRKAQ
>NZ_CP053816.1|WP_011791301.1|2983234_2983630_-|hypothetical-protein
MSLWHEELELALLNLEDSKASCDVMTYVISHILAKSDIPHQCRVGFVETVHSKTQINPHCWIELKDGWGIDLTLRRWLGDEDRWPHGVFRLSDYPQVQFWGTPLFAPKLDDEEINAMSDHLIETVKIPVCC
>NZ_CP053816.1|WP_000901446.1|2982550_2982820_+|hypothetical-protein
MLGQNQTEIHQFDVCGRVYYRGVNYTEKEGELAVETVEATSHDEAEALFKSLQDEYARECNRTVERIDITFTIDLTIAESDNDEPYLVM
>NZ_CP053816.1|WP_001747916.1|2982287_2982473_+|hypothetical-protein
MYRLILTNQKKRTREYQPSDAGYRAALKATRKFLEQNPQGNAVLYGHGVCESFTIRNMPEA
>NZ_CP053816.1|WP_032481337.1|2996197_2996566_+|helix-turn-helix-domain-containing-protein
MTVDVNETLNALRSEIAEMKQLLAQFVENTVSDGSKSNLPPSDKEYFTVDEAAAYVGAKRSYIYRLTHEKRLSFTKPGGNRVLIKRSDLQAWLEKNRVKSADELHQDVANYITSFPRGRKAS
>NZ_CP053816.1|WP_032481345.1|2996562_2997786_-|site-specific-integrase
MKVSVNKRNPNSKGLQQLRLVYYYGVVEGEDGKKRPKRDYEPLELYVYQNPKTQAERQHNKEMLRQAEAARSARLVESHANKFQLEDRVKLASSFYEYYDRLTSTKEPGSTSNYSIWVSAGKHLRSYHGRAELTFEEIDKKFLEGFRKYLLEEPLTKSKSKLAKNTASSYFNKVRAALNEAYREGIIRDNPVQRVKSVKAENTKRTYLTLDEVRAMTKAECRYDVLKRAFLFSCTTGLRWSDINKLTWSEIEEFEPGHYRIIFDQQKLKNGGNSLVYLDLPDSAVTLLNIQNREGPDDRVFVGLKYNSYMNVALLQWAMRAGITKHVTFHAGRHTFAVAQLNRGVDIYSLSRLLGHSELRTTEIYADILESRRVTAMRGFPDIFEDKVKESGACCPHCGKSVMNKTL
>NZ_CP053816.1|WP_149595617.1|2997988_2999350_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE
MTTDTIVAQATAPGRGGVGIIRVSGPLAAHVAQTVTGRTLRPRYAEYLPFTDEDGQQLDQGIALFFPNPHSFTGEDVLELQGHGGPVVMDMLIRRILQIKGVRPARPGEFSERAFLNDKMDLTQAEAIADLIDASSEQAAKSALQSLQGEFSKRIHTLVESLIHLRIYVEAAIDFPEEEIDFLADGKVSADLQTIIDNLAAVRREANQGAIMREGMKVVIAGRPNAGKSSLLNALSGKESAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLRDASDAVEKIGIERAWEEIRQADRVLFMVDGTTTEATDPQDIWPDFVDKLPENIGITVIRNKADQTGEPLGICHVNQPTLIRLSAKTGQGVDALRQHLKECMGFSGNQESGFMARRRHLDALERAAEHLAIGQQQLEGYMAGEILAEELRIAQQHLNEITGEFSSDDLLGRIFSSFCIGK
>NZ_CP053816.1|WP_000378235.1|2999443_3001069_-|membrane-protein-insertase-YidC
MDSQRNILLIALALVSFLLFQQWQVAKNPAPQATQQAQSTGAAPAPSFSDELDPTPAQNVAAKAKTITVSTDVLTLSIDTLGGDVVSAKLNQYSEELNSPESFVLLQNTQGHQFIAQSGLVGPQGIDVTSNNRPAYQVSADSFTLAEGQDELRIPMTYQANGIDYTKTFILKRGSYAVDVVFDVANNSGSEATLGMYAHLRQNLLDSGGNLAMPTYRGGAYSTSDVRYKKYSFDDMKDRNLSAPNDVTVNWVAMIQHYFASAWIPRDEPQAQLYSRVINNLGDMGIRTPNKTIANGDKAEFEATLWVGPKLQDQMAATAPNLDLVVDYGWLWFIAKPLHWLLSVIQTFVGNWGVAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLQAMRERIGDDRQRMSQEMMELYKKEKVNPLGGCLPILLQMPIFIALYWALMESVELRHSPFFGWIHDLSAQDPYYILPLLMGASMFVIQKMSPTTITDPMQQKIMTFMPVMFTFFFLWFPSGLVLYWLVSNIVTLIQQTLIYKALEKKGLHSK
>NZ_CP053816.1|WP_001886301.1|3001071_3001329_-|membrane-protein-insertion-efficiency-factor-YidD
MATPLSPFSWLAIGIVKLYQWFISPLIGPRCRFTPTCSTYAIEALRAHGFIKGCWLSTKRLLKCHPLNEGGFDPVPPVQKQDRDK
>NZ_CP053816.1|WP_001884349.1|3001295_3001652_-|ribonuclease-P-protein-component
MSTYAFNRELRLLTPEHYQKVFQQAHSAGSPHLTIIARANNLSHPRLGLAVPKKQIKTAVGRNRFKRICRESFRLHQNQLANKDFVVIAKKSAQDLSNEELFNLLGKLWQRLSRPSRG
>NZ_CP053816.1|WP_000044781.1|3001664_3001802_-|50S-ribosomal-protein-L34
MSKRTFQPSVLKRKRTHGFRARMATANGRKVLNARRAKGRKRLSK
>NZ_CP053816.1|WP_000593848.1|3002043_3002781_-|amino-acid-ABC-transporter-ATP-binding-protein
MIKLQNIHKRFGTSEVLKGIDLEIQRGEIVVIIGSSGTGKSTLLRCVNFLEQADQGSIRIDELTVDTHKHTKVDVLALRRKTGFVFQNYALFAHLTARQNIAEALITVRGWKKAQAHQRAQQILDDIGLGDKGDSYPAALSGGQQQRVGIGRAMALQPELLLFDEPTSALDPEWVGEVLALMKKLATQHQTMLVVTHEMQFAKEVADRVIFMAEGKIVEQGSPQDIFDHPQDPRLRKFLNQVGIR
>NZ_CP053816.1|WP_000505208.1|3002777_3003449_-|amino-acid-ABC-transporter-permease
MGFDFHYMLELLPILLKYLGTTLEMASWGLVFALILALILANIRVFKVPVLDPLSQLYISFFRGTPLLVQLFLLYYGLPQVFPLLVGLDAFSAAVIGLTLHFAAYMAESIRAAIIGIDRSQMEASLSVGMTTSQAMRRIILPQATRVALPSLMNYFIDMIKSTSLAFTLGVAEIMAKAQMEASSSFRFFEAFLAVALIYWVVVLVLTRLQSWAEQKLNKAYAR
>NZ_CP053816.1|WP_000683499.1|3003526_3004273_-|amino-acid-ABC-transporter-substrate-binding-protein
MKHWFNIALAALALSSATVQAATEVKVGMSGRYFPFTFVKQDELQGFEVDVWNEIGKRNDYKVEFVTANFSGLFGLLETGRIDTISNQITITDARKAKYLFSDPYVIDGAQITVRKGNEAIKGIDDLAGKTVAVNLGSNFEQLLRNHDKDGKINIKTYDTGIEHDVALGRADAFVMDRLSALELIEKTGLPLQLAGSPFETIENAWPFVNNEKGQQLQGEVNKALAAMRADGTLSQIALKWFGTDISQ

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP053816_1	1.1\|2567108\|37\|NZ_CP053816\|PILER-CR	2567108-2567144	37	NC_049942	Escherichia phage JLK-2012, complete sequence	23524-23560	4	0.892
NZ_CP053816_1	1.1\|2567108\|37\|NZ_CP053816\|PILER-CR	2567108-2567144	37	NC_021742	Serratia liquefaciens ATCC 27592 plasmid unnamed, complete sequence	35428-35464	4	0.892

1. spacer 1.1|2567108|37|NZ_CP053816|PILER-CR matches to NC_049942 (Escherichia phage JLK-2012, complete sequence) position: , mismatch: 4, identity: 0.892

taggtcgccagttcgattccggcagccggcaccactt	CRISPR spacer
caggtcgccagttcgattccggtagccggcaccatat	Protospacer
.*********************.***********. *

2. spacer 1.1|2567108|37|NZ_CP053816|PILER-CR matches to NC_021742 (Serratia liquefaciens ATCC 27592 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.892

taggtcgccagttcgattccggcagccggcaccactt	CRISPR spacer
taggtcaccagttcgattccggtagccggcaccaatc	Protospacer
******.***************.*********** *.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

656198 : 662815

Staphylococcus_phage(66.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000210573.1\|656198_657332_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	1.4e-64	40.4
WP_033932838.1\|657343_658594_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	1.7e-100	49.7
WP_000543544.1\|658693_659143_+	transcriptional regulator NrdR	NA	NA	NA	NA
WP_175247449.1\|659168_660272_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	2.0e-44	33.3
WP_071193055.1\|660276_660930_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	4.0e-32	38.7
WP_123011119.1\|660970_662080_+	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	6.7e-64	39.8
WP_123011118.1\|662344_662815_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	8.9e-34	48.0

DBSCAN-SWA_2

1527277 : 1533565

Vibrio_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_032479745.1\|1527277_1527625_-	DUF1293 family protein	Q783U4	Vibrio_phage	5.0e-50	84.3
WP_175246066.1\|1527627_1528818_-	replication initiation factor domain-containing protein	A0A1W6UG38	Vibrio_phage	7.0e-160	70.4
WP_148512340.1\|1528807_1529023_-	hypothetical protein	A0A1W6UGD1	Vibrio_phage	1.0e-24	79.1
WP_175247507.1\|1529206_1529581_+	hypothetical protein	R9TE55	Vibrio_phage	4.3e-47	79.8
WP_000021944.1\|1530026_1530416_-	helix-turn-helix transcriptional regulator	Q9MBV1	Vibrio_virus	8.2e-25	82.1
WP_000273561.1\|1530539_1531682_+	hypothetical protein	NA	NA	NA	NA
WP_000590111.1\|1531692_1531974_+	hypothetical protein	NA	NA	NA	NA
WP_000022883.1\|1531970_1532324_+	hypothetical protein	NA	NA	NA	NA
WP_053034453.1\|1532392_1532611_+	hypothetical protein	NA	NA	NA	NA
WP_000021944.1\|1533175_1533565_-	helix-turn-helix transcriptional regulator	Q9MBV1	Vibrio_virus	8.2e-25	82.1

DBSCAN-SWA_3

2266172 : 2273365

Anguillid_herpesvirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001162850.1\|2266172_2266601_-	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	1.0e-20	38.4
WP_001959105.1\|2266804_2268094_-	aminopeptidase PepB	Q6GYZ8	Mycoplasma_phage	6.5e-34	34.0
WP_000872174.1\|2268313_2268508_-	Fe-S cluster assembly protein IscX	NA	NA	NA	NA
WP_001124187.1\|2268556_2268895_-	ISC system 2Fe-2S type ferredoxin	NA	NA	NA	NA
WP_001959107.1\|2268908_2270759_-	Fe-S protein assembly chaperone HscA	A0A0N9QXN8	Chrysochromulina_ericina_virus	1.5e-105	40.9
WP_001105750.1\|2270782_2271298_-	co-chaperone HscB	NA	NA	NA	NA
WP_000301571.1\|2271346_2271670_-	iron-sulfur cluster assembly protein IscA	A0A2H4N7N5	Lake_Baikal_phage	3.0e-25	50.5
WP_000331703.1\|2271730_2272114_-	Fe-S cluster assembly scaffold IscU	A0A218MKD1	uncultured_virus	5.4e-53	78.2
WP_175246178.1\|2272150_2273365_-	IscS subfamily cysteine desulfurase	A0A0H3TPH2	Faustovirus	2.0e-32	30.5

DBSCAN-SWA_4

2506447 : 2513672

uncultured_Mediterranean_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001914090.1\|2506447_2507335_+	cysteine synthase CysM	A0A1X9I5K7	Streptococcus_phage	2.4e-56	41.1
WP_071179763.1\|2507602_2510191_+	DNA mismatch repair protein MutS	A0A1V0SC35	Catovirus	4.9e-33	23.2
WP_123011330.1\|2510284_2511292_-	RNA polymerase sigma factor RpoS	F4YCU2	Synechococcus_phage	7.8e-35	34.2
WP_000177559.1\|2511365_2512301_-	murein hydrolase activator NlpD	D7RWE0	Brochothrix_phage	7.8e-05	34.7
WP_057550676.1\|2512300_2512927_-	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	5.7e-36	51.5
WP_000698379.1\|2512919_2513672_-	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	8.0e-69	53.3

DBSCAN-SWA_5

2823527 : 2834434

Enterobacteria_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_148537409.1\|2823527_2825735_-	glycosyltransferase	A0A1V0SAH6	Catovirus	3.8e-18	41.7
WP_175247583.1\|2825941_2827732_-	ABC transporter ATP-binding protein	A0A076FI99	Aureococcus_anophage	1.3e-21	27.0
WP_148537405.1\|2827724_2828645_-	hypothetical protein	NA	NA	NA	NA
WP_148537403.1\|2828647_2829208_-	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	5.1e-36	45.4
WP_148537401.1\|2829204_2830392_-	hypothetical protein	NA	NA	NA	NA
WP_148537399.1\|2830399_2831254_-	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	1.6e-28	34.0
WP_148537397.1\|2831292_2832165_-	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	2.6e-111	67.9
WP_175247584.1\|2832188_2833253_-	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	3.6e-99	52.2
WP_057558688.1\|2833495_2834434_+	ADP-glyceromanno-heptose 6-epimerase	R9S880	Prochlorococcus_phage	1.6e-34	35.2

DBSCAN-SWA_6

2861538 : 2869079

Stx2-converting_phage(33.33%)

integrase

attL 2857195:2857211|attR 2865634:2865650

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2857195:2857211	attL	NA	NA	NA	NA
WP_175246280.1\|2861538_2862795_+\|integrase	integrase arm-type DNA-binding domain-containing protein	A0A1W6JPG6	Morganella_phage	4.8e-74	38.8
WP_175246281.1\|2862796_2863135_+	hypothetical protein	NA	NA	NA	NA
WP_075607785.1\|2863331_2863634_+	type II toxin-antitoxin system HigB family toxin	F5A3A2	Riemerella_phage	8.9e-11	33.0
WP_000354815.1\|2863665_2864037_+	transcriptional regulator	A0A222YXG1	Escherichia_phage	1.2e-30	56.4
WP_175246282.1\|2864062_2866489_+	DEAD/DEAH box helicase family protein	G0T5H3	Wiseana_iridescent_virus	9.3e-26	27.0
2865634:2865650	attR	NA	NA	NA	NA
WP_095481607.1\|2867582_2868785_-	ImmA/IrrE family metallo-endopeptidase	A0A0P0ZCT8	Stx2-converting_phage	7.6e-29	57.4
WP_001197622.1\|2868794_2869079_-	type II toxin-antitoxin system HigB family toxin	A0A0P0ZE17	Stx2-converting_phage	1.7e-24	58.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_CP053819

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 23915

Vibrio_phage(35.29%)

integrase

attL 11726:11738|attR 25890:25902

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_032072017.1\|846_1197_+	hypothetical protein	NA	NA	NA	NA
WP_032072016.1\|1929_2469_+	hypothetical protein	NA	NA	NA	NA
WP_080527608.1\|2645_3005_+	hypothetical protein	R9TNL4	Vibrio_phage	2.7e-14	39.8
WP_032072014.1\|3054_3297_-	hypothetical protein	NA	NA	NA	NA
WP_032072013.1\|3369_3693_-	hypothetical protein	Q6V7U0	Burkholderia_virus	5.4e-06	30.6
WP_175247732.1\|3750_4563_-	3'-5' exoribonuclease	A0A1I9KF44	Aeromonas_phage	2.2e-27	38.2
WP_032072011.1\|4621_5569_-	hypothetical protein	A0A291L9Z9	Bordetella_phage	6.0e-21	27.7
WP_175247733.1\|5618_6809_-	hypothetical protein	A0A1I9KG78	Aeromonas_phage	8.9e-14	27.2
WP_032072009.1\|6857_7055_-	hypothetical protein	NA	NA	NA	NA
WP_175247886.1\|7137_7356_-	hypothetical protein	NA	NA	NA	NA
WP_175247734.1\|7511_8702_+\|integrase	tyrosine-type recombinase/integrase	A0A067ZJC5	Vibrio_phage	2.5e-64	37.1
WP_175247735.1\|8745_9312_+	PadR family transcriptional regulator	H9EB19	Vibrio_phage	1.8e-09	28.2
WP_175247736.1\|9326_9914_+	hypothetical protein	NA	NA	NA	NA
WP_175247887.1\|9936_10941_+	nucleoid-associated protein YejK	A0A1V0E8C0	Vibrio_phage	2.3e-111	59.5
WP_175247737.1\|10937_11669_+	hypothetical protein	NA	NA	NA	NA
WP_175247738.1\|11671_12154_+	hypothetical protein	A0A1W6JPA7	Morganella_phage	1.9e-23	39.6
11726:11738	attL	NA	NA	NA	NA
WP_175247888.1\|12166_12568_+	hypothetical protein	NA	NA	NA	NA
WP_175247889.1\|12564_14304_+	DEAD/DEAH box helicase	A0A1X9HX80	Ruegeria_phage	6.3e-117	41.3
WP_175247742.1\|14317_14761_+	hypothetical protein	NA	NA	NA	NA
WP_175247743.1\|14763_15519_+	hypothetical protein	R9VWB9	Serratia_phage	5.8e-43	43.2
WP_080527605.1\|15515_15833_+	hypothetical protein	A0A2I7QIG7	Vibrio_phage	2.7e-18	50.5
WP_095490167.1\|15829_16144_+	hypothetical protein	A0A2D0YGQ8	Vibrio_phage	3.4e-21	46.4
WP_175247773.1\|16206_16656_+	hypothetical protein	NA	NA	NA	NA
WP_032071992.1\|16995_17244_+	hypothetical protein	NA	NA	NA	NA
WP_080527603.1\|17311_17743_+	transglycosylase SLT domain-containing protein	M4R0Y9	Tetraselmis_viridis_virus	1.4e-28	50.7
WP_175247744.1\|17739_18144_+	hypothetical protein	NA	NA	NA	NA
WP_032071988.1\|18323_18734_+	hypothetical protein	NA	NA	NA	NA
WP_080527612.1\|19196_19901_+	hypothetical protein	NA	NA	NA	NA
WP_175247745.1\|19890_21609_+	protein PacB	Q71T61	Escherichia_phage	6.5e-98	41.3
WP_032071984.1\|22579_23263_+	DUF2786 domain-containing protein	A0A2P9JZH4	Alteromonadaceae_phage	4.9e-25	31.9
WP_032071983.1\|23324_23915_+\|integrase	tyrosine-type recombinase/integrase	A0A2H4J6I5	uncultured_Caudovirales_phage	1.5e-25	40.2
25890:25902	attR	NA	NA	NA	NA

DBSCAN-SWA_2

28191 : 30566

Vibrio_phage(100.0%)

integrase

attL 27821:27836|attR 32805:32820

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
27821:27836	attL	NA	NA	NA	NA
WP_175247752.1\|28191_29343_+\|integrase	tyrosine-type recombinase/integrase	A0A2I7R1N2	Vibrio_phage	6.2e-36	31.4
WP_175247753.1\|29430_29619_+	hypothetical protein	NA	NA	NA	NA
WP_175247754.1\|29636_30146_+	DUF262 domain-containing protein	U3PFK3	Vibrio_phage	1.5e-50	59.9
WP_032071968.1\|30152_30566_+	hypothetical protein	A0A2I7RNG1	Vibrio_phage	1.7e-20	43.1
32805:32820	attR	NA	NA	NA	NA

DBSCAN-SWA_3

35187 : 36366

Escherichia_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_080527596.1\|35187_36366_+	hypothetical protein	A0A222YXT1	Escherichia_phage	2.3e-38	34.7

DBSCAN-SWA_4

40227 : 50171

Escherichia_phage(77.78%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_095490140.1\|40227_41214_+	hypothetical protein	A0A222YXZ0	Escherichia_phage	3.2e-25	26.5
WP_175247890.1\|42032_42242_+	hypothetical protein	NA	NA	NA	NA
WP_032071946.1\|42487_44086_+	hypothetical protein	A0A222YWC7	Escherichia_phage	4.5e-69	29.2
WP_175247762.1\|44159_44558_+	hypothetical protein	NA	NA	NA	NA
WP_175247763.1\|44557_46108_+	hypothetical protein	A0A1B0V7E4	Salmonella_phage	9.7e-61	32.2
WP_032071943.1\|46120_46792_+	hypothetical protein	A0A222YXT7	Escherichia_phage	9.5e-13	32.1
WP_032071942.1\|46796_47441_+	hypothetical protein	A0A222YY02	Escherichia_phage	1.0e-24	35.9
WP_032071941.1\|47454_47952_+	hypothetical protein	A0A222YWE4	Escherichia_phage	5.8e-15	31.4
WP_175247764.1\|47951_48515_+	hypothetical protein	Q1MVL0	Enterobacteria_phage	2.0e-24	39.7
WP_032071939.1\|48524_48872_+	hypothetical protein	NA	NA	NA	NA
WP_080527595.1\|48864_49371_+	hypothetical protein	A0A077SLH8	Escherichia_phage	6.9e-16	34.7
WP_032071937.1\|49373_50171_+	hypothetical protein	Q71TC9	Escherichia_phage	4.4e-25	31.7

DBSCAN-SWA_5

53203 : 59440

Escherichia_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_032072045.1\|53203_54628_+	bleomycin hydrolase (P1-like BpiA)	Q71TP2	Escherichia_phage	6.0e-65	33.4
WP_080527593.1\|54737_56147_+	hypothetical protein	NA	NA	NA	NA
WP_032072042.1\|56151_56589_+	hypothetical protein	NA	NA	NA	NA
WP_080527592.1\|56592_57147_+	hypothetical protein	NA	NA	NA	NA
WP_032072040.1\|57260_57860_+	protein (P1-like Hdf)	O21969	Escherichia_phage	1.8e-10	36.2
WP_175247766.1\|57856_59440_+	hypothetical protein	Q1MVM7	Enterobacteria_phage	1.7e-15	28.5

DBSCAN-SWA_6

63314 : 78712

Enterobacteria_phage(28.57%)

portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_175247768.1\|63314_70187_+	DEAD/DEAH box helicase family protein	Q1MVN7	Enterobacteria_phage	3.8e-282	34.5
WP_175247769.1\|70274_70691_+	hypothetical protein	NA	NA	NA	NA
WP_032072029.1\|70840_72505_+\|portal	portal protein (P1-like Prt)	Q9XJG3	Escherichia_phage	5.0e-79	34.5
WP_114729420.1\|72497_73520_+	hypothetical protein	Q1MVN5	Enterobacteria_phage	2.9e-29	35.3
WP_175247770.1\|73639_73960_-	hypothetical protein	NA	NA	NA	NA
WP_175247771.1\|73949_74615_-	cobyrinic acid ac-diamide synthase	Q2A085	Sodalis_phage	3.1e-24	34.3
WP_175247774.1\|75313_76336_+	replication initiation protein	NA	NA	NA	NA
WP_175247772.1\|76452_76824_-	hypothetical protein	A0A1S6L1T5	Vibrio_phage	7.8e-09	38.4
WP_175247891.1\|76939_77734_-	Dam family site-specific DNA-(adenine-N6)-methyltransferase	A0A222YYM0	Escherichia_phage	2.5e-20	29.3
WP_032072023.1\|77988_78357_-	hypothetical protein	NA	NA	NA	NA
WP_080527586.1\|78346_78712_-	DUF4406 domain-containing protein	A0A2I7QNK0	Vibrio_phage	3.9e-13	43.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP053817

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP053816

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. NZ_CP053819

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection