CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_LT549889	Mycolicibacterium aurum isolate liquid chromosome I	3 crisprs	csa3,cas3,WYL,DEDDh,DinG	0	1	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_LT549889_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LT549889_1

90668-90742

Orphan

Consensus_repeat	Method
GCACCACCACGACTAGGCACCCACCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_LT549889_1

>merge|NZ_LT549889|1|90668-90742|CRISPRCasFinder
GCACCACCACGACTAGGCACCCACCACGACTAGGCACCACCACGACTCGGCACCACCACGACTAGGCACCACCAC

>NZ_LT549889|1|1|90668-90742|CRISPRCasFinder
GCACCACCACGACTAGGCACCCACCA	CGACTAGGCACCACCACGACTCG
GCACCACCACGACTAGGCACCACCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LT549889.1\|WP_087019414.1\|94338_94623_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225993
NZ_LT549889.1\|WP_087019408.1\|92567_92849_+\|DUF1876-family-protein	unknown	unknown	gnl\|CDD\|378103
NZ_LT549889.1\|WP_087019399.1\|85409_85856_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|378988
NZ_LT549889.1\|WP_087019411.1\|93873_94152_+\|DUF1918-domain-containing-protein	unknown	unknown	gnl\|CDD\|378101
NZ_LT549889.1\|WP_087019379.1\|79272_81846_+\|cation-transporting-P-type-ATPase	unknown	unknown	gnl\|CDD\|223550
NZ_LT549889.1\|WP_087019385.1\|81880_82663_+\|HPF/RaiA-family-ribosome-associated-protein	unknown	unknown	gnl\|CDD\|379821
NZ_LT549889.1\|WP_087019388.1\|82796_83690_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_LT549889.1\|WP_087031536.1\|88947_90627_+\|GAF-domain-containing-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_LT549889.1\|WP_087019421.1\|97043_97802_+\|oxidoreductase	unknown	unknown	gnl\|CDD\|224852
NZ_LT549889.1\|WP_087019424.1\|97798_99091_+\|Ni/Fe-hydrogenase-subunit-alpha	unknown	unknown	gnl\|CDD\|225798
NZ_LT549889.1\|WP_087019377.1\|78002_78692_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LT549889.1\|WP_162295784.1\|95104_96202_+\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|379938
NZ_LT549889.1\|WP_087031533.1\|78698_79130_-\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|107221
NZ_LT549889.1\|WP_087019418.1\|96194_97043_+\|FAD/NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|99817
NZ_LT549889.1\|WP_087019392.1\|83762_84350_+\|hypothetical-protein	unknown	unknown	unknown
NZ_LT549889.1\|WP_087019395.1\|84364_85240_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_LT549889.1\|WP_087019427.1\|99087_99573_+\|hydrogenase-maturation-protease	unknown	unknown	gnl\|CDD\|99872
NZ_LT549889.1\|WP_162295778.1\|91765_91960_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LT549889.1\|WP_087019402.1\|87873_88878_+\|1-phosphofructokinase-family-hexose-kinase	unknown	unknown	gnl\|CDD\|238570
NZ_LT549889.1\|WP_087031539.1\|92910_93858_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180

Protein	Function_ID	Function_description	E-value
NZ_LT549889.1\|WP_087019414.1\|94338_94623_+\|hypothetical-protein	gnl\|CDD\|225993	COG3462, COG3462, Predicted membrane protein [Function unknown].	1.95035e-05
NZ_LT549889.1\|WP_087019408.1\|92567_92849_+\|DUF1876-family-protein	gnl\|CDD\|378103	pfam08962, DUF1876, Domain of unknown function (DUF1876). This domain is found in a set of hypothetical bacterial proteins.	5.65236e-27
NZ_LT549889.1\|WP_087019399.1\|85409_85856_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|378988	pfam12900, Pyridox_ox_2, Pyridoxamine 5'-phosphate oxidase. Pyridoxamine 5'-phosphate oxidase is a FMN flavoprotein that catalyzes the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP). This entry contains several pyridoxamine 5'-phosphate oxidases, and related proteins.	2.17699e-23
NZ_LT549889.1\|WP_087019411.1\|93873_94152_+\|DUF1918-domain-containing-protein	gnl\|CDD\|378101	pfam08940, DUF1918, Domain of unknown function (DUF1918). This domain, found in various hypothetical bacterial proteins, has no known function.	2.45399e-27
NZ_LT549889.1\|WP_087019379.1\|79272_81846_+\|cation-transporting-P-type-ATPase	gnl\|CDD\|223550	COG0474, MgtA, Cation transport ATPase [Inorganic ion transport and metabolism].	0
NZ_LT549889.1\|WP_087019385.1\|81880_82663_+\|HPF/RaiA-family-ribosome-associated-protein	gnl\|CDD\|379821	pfam16321, Ribosom_S30AE_C, Sigma 54 modulation/S30EA ribosomal protein C-terminus. This domain often occurs at the C-terminus of proteins containing pfam02482.	1.06825e-15
NZ_LT549889.1\|WP_087019388.1\|82796_83690_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	1.0393e-25
NZ_LT549889.1\|WP_087031536.1\|88947_90627_+\|GAF-domain-containing-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.16368e-41
NZ_LT549889.1\|WP_087019424.1\|97798_99091_+\|Ni/Fe-hydrogenase-subunit-alpha	gnl\|CDD\|225798	COG3259, FrhA, Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion].	2.69401e-88
NZ_LT549889.1\|WP_162295784.1\|95104_96202_+\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|379938	pfam17179, Fer4_22, 4Fe-4S dicluster domain.	7.99879e-50
NZ_LT549889.1\|WP_087031533.1\|78698_79130_-\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|107221	cd06464, ACD_sHsps-like, Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.	9.74825e-28
NZ_LT549889.1\|WP_087019418.1\|96194_97043_+\|FAD/NAD(P)-binding-protein	gnl\|CDD\|99817	cd06221, sulfite_reductase_like, Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is linked to ferredoxin and reduces NH2OH and SeO3 at a lesser rate than it's normal substate SO3(2-). Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to orotate coupled with the reduction of NAD+.	9.14465e-99
NZ_LT549889.1\|WP_087019421.1\|97043_97802_+\|oxidoreductase	gnl\|CDD\|224852	COG1941, FrhG, Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion].	4.9064e-40
NZ_LT549889.1\|WP_087019395.1\|84364_85240_-\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	6.63258e-27
NZ_LT549889.1\|WP_087019427.1\|99087_99573_+\|hydrogenase-maturation-protease	gnl\|CDD\|99872	cd00518, H2MP, Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing and assembly with other subunits. Hydrogenase maturation endopeptidases are responsible for the proteolytic processing, liberating a short C-terminal peptide by cleaving after a His or an Arg residue, e.g., HycI (E. coli) is involved in processing of HypE, the large subunit of hydrogenase 3. This cleavage is nickel dependent. This CD also includes such hydrogenase-processing proteins as HydD, HupW, and HoxW, as well as, proteins of the F420-reducing hydrogenase of methanogens (e.g., FrcD). Also included, is the Pyrococcus furiosus FrxA protein, a bifunctional endopeptidase/ sulfhydrogenase found in NADP-reducing hyperthermophiles.The Pyrococcus FrxA is not related to those found in Helicobacter pylori.	1.987e-29
NZ_LT549889.1\|WP_087019402.1\|87873_88878_+\|1-phosphofructokinase-family-hexose-kinase	gnl\|CDD\|238570	cd01164, FruK_PfkB_like, 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose 6-phosphate pathway, which responsible for breakdown of the galactose moiety during lactose metabolism by bacteria such as L. lactis.	5.35677e-97
NZ_LT549889.1\|WP_087031539.1\|92910_93858_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	7.96723e-22

>NZ_LT549889.1|WP_087031536.1|88947_90627_+|GAF-domain-containing-sensor-histidine-kinase
MRPLRETLSQLRLRELLGEVQDRVERIAETRDRLDGLLDSMLAVTSGLELDETLRTIVRTAIDLVDARYGALGVRGCDHELVEFIYHGIDEPTRRQIGHLPEGRGVLGVLIDDPKPIRLDNISRHPDSVGFPAHHPPMRTFLGVPIRIRDEVFGNLYLTEKTGGQPFTDDDEVLVQALAAAAGIAIENARLYRQSTVRRSWIEATRDIGTEMLSGADPSLAFSLMADKARSISGSWVTLVAVRADLDEPADPVDELVVVAASGDGPEAALAVIAAEGTPIGDVVSTQQARRFAGLELVDDGSVGGPALVLPICVGGSSTAGVLVALRVPGQPDFTDDELEAMASFVAQAALAWQLATSQSQLRELDILTDRDRIARDLHDHVIQRLFAVGLAVQGTIPRVRVPDVAQRLSDCVDDLQQVIHEIRTTIFDLHGHHHGGKGFRQRLDEAIAGFATSDLHITVKFAGPLSVVSAGVAEHAEAVVREAVSNAVRHAHATKLEVSVAADDELCIEVRDDGCGLPAGARTSGLANLAQRADEVGGTFSVQALSTGGTLLRWCAPI
>NZ_LT549889.1|WP_087019402.1|87873_88878_+|1-phosphofructokinase-family-hexose-kinase
MGCGGDTRNVSQRAVNPPAIVTLTMNPALDLTADADEVRPTEKIRCHGERYDAGGGGINVARYAQALGVPSAAVFTAGGSTGARLAGLVATSGVGCTQIGIRGSTRENFTVNDHASGKQFRFVLAGPRLEEDEQTQCLTAVAHLAESARYIVASGSLPPGASPDLYQRVATVCAEAGVPLILDTSGGGLTHVTSGVFLLKPSLRELRECSGRTLDTEDEQDRAARELIDRGVAQTVLVSLGARGSLLVTASVSIRYPAVRVAAVSGVGAGDAMVAGLTVGLVRGWELTRCVQLGIAAATAKLQTPGTAAYESAEVQRYFAALAAEREFAVRNLR
>NZ_LT549889.1|WP_087019399.1|85409_85856_+|pyridoxamine-5'-phosphate-oxidase-family-protein
MTDTHTMDVLSAPQCWDLLAGTALGRLVTSVDGVPAIFPVNYAVQDRTILFRTAQGTKLVSAAINNNVLFEADGYCLSEGWSVIVAGVARSVRGDEDIAEAERAGLISWTDSEKEHFVRIRPRGVTGRRFRFAVQPGAGTAAEDPVLG
>NZ_LT549889.1|WP_087019395.1|84364_85240_-|universal-stress-protein
MTSSAGLGILVGIDGSPESHAAVRWAADEAVLRRRPVTLMHVVSPIIASWPIAAVLSDYQVWQEEHADNVIARALETLRTAVPGSPPDVRVERRHGGPVAELAAASADAELIVLGSRGLGPVGAAVLGSVSRTLLHHARCPVVLVKEGVVRSTDRGLPVVLGIDGSPASEAATAFAFDEASRRGVDLVALHAWSDVAVFPFLGMDWHQFEEQGHEVLAERLAGWQERYPDVTIRRRVVCDKPARWLIDESNQSQLVVVGSRGRGGIPGMLLGSVSTSVAESALSPVVVIRA
>NZ_LT549889.1|WP_087019392.1|83762_84350_+|hypothetical-protein
MQTFAFNLGARFRCLLGVNPLVRTSDRVQAMAELAVVVLALFTVAVAAAVGTAVHDEVTRELAAHRLVRQQIVAIVSADSQDAAQPFAESSVTEIRWEFDGKPHTDTIHTQPLRAGDRLTVWVDAAGERTLAVPSDADAVVLAIVTALAVWAAVLTPATVLLLLLRNSLNGARFTAWDRELDDLADDGGRQDNST
>NZ_LT549889.1|WP_087019388.1|82796_83690_+|universal-stress-protein
MTFQSTTNLNGIVVAVDGSPSSDSAAAWAAREAARRDVTLTLVYVKPSDEVGPWLDLPISSEYLQERDRLADEVIEGSHRHIATALSGTRDVRINKLVLDGPKLPALIDLSKDADLMVVGCRGLGGLARLLLGSTSSALVHHSHCPVAVIHDEISVADLEATAPVVVGVDAMPASELAVAIAFDEASRRGVELVAVHTWMHPADFYVDVAADDVAVQAEEELAQRLAGWCERYPDVVVRRVVGRDNPAHRLLTEARGAQLLVVGSHGRGGFAGQLLGSVSWAVVQAATIPVIVARHG
>NZ_LT549889.1|WP_087019385.1|81880_82663_+|HPF/RaiA-family-ribosome-associated-protein
MADGVGASPAADVDITMRGSFPGAEEYANIKIGGLGRFARNPITHARLRLTQGDGGHAETAVVGQVNLDFLGRHIRAQVAAATAREVIDKLEERARRQLEQVRECREPRRGPAGAPPWRQGRALPVPGPNVDGARISRRKSFAMAPCTVDEALTEMDLLDYDFHLFNEIGSGAAAVVYRGGPTGLRLALVAPALSSAVAPFERPVTISPHPVPCLREDAAVRRMALMNLPFLFYIDAAGGRASVLYRRLDGDLAVITPAG
>NZ_LT549889.1|WP_087019379.1|79272_81846_+|cation-transporting-P-type-ATPase
MLSTQTQGLSAQRAAALLAEFGPNRVKVRRARPWWQILITEMVHFFALLFWAAGALAFVAGLPQLGVAIFGVVLLNGLFAFAQEERAEHAAEKLRRLLPSQARVLRDGALVTIPSDDLVPGDAMVLAEGDRISADAEITGAAGLAVDTSAMTGESVPEHPMPGQLLRAGCFVIEGEATAIVTATGGRTYLAKIVGLTSEHGGMPTPLRRELTRASRVIAAVAMGVGAVFFTVSAALGMPLQDGFLFAVGVTVAVVPEGLLPTVTLSLAAGAQRMAKRHALVRHLEAVQTLGSTTYICTDKTGTLTQNEMSVVRCWTPDGSATIRGVGYEPTAEVTADPDAVGAIRRLAAAARLCSSGHVACEDGNWVPRGDPMEAALDAFARRVGAHETDGEGDEQARFPFDARRRRMSVVIGDRVLVKGAPDAVLPLCGAASAPSHEVRRMAAQGLRVLAVATRVLHSDIGIPTSARDAEADLTVLGLVGLEDPPRPEVADVLRACRRAGIRVAMVTGDHPDTAQAVAREVGLMSEGEPLLGAGLPDDLDALGDLLDHDGLVVARVDPETKLRIARALRQRGHVVAMTGDGVNDAPALQEAAIGVAMGRSGTDVARAAADLVLLDDNFETILMAIEEGRSTFTNIQRFLTYHLSDNVAELAPFVVWALSAGHIPLAIGVLQVLALDIGTDVFPALALGAEPPDKRTLGRAPVRGHLLDRAVLLRAFTVLGPVEATFAMLAFVGSFVAAGWWPGEPFPAGTTLQAASGAAFTAIVLGQVANAFACRSVSVPAWRLAPGGNKLLIGAVSAELALLVLLLYVDPIAHLLSHAGPTVAGFLLAALAIPAVLLVDGASKRRRRPGTDDFRP
>NZ_LT549889.1|WP_087031533.1|78698_79130_-|Hsp20/alpha-crystallin-family-protein
MSNVAVQQQHRSAWPELSDLFPGLPSWANLRPMFGGHPIKVEDDIREGQYELKAEIPGVDPDKDVDITVRNGMLTIKAERSEKKETNGHSEFSYGSFTRTVALPAGADEDGIKAHCEKGVLTVSVPLKEPKSPEKHIAVESAG
>NZ_LT549889.1|WP_087019377.1|78002_78692_-|hypothetical-protein
MGRQHNVVAALAAAVGTAALYRAHVRPWIHAWGARPDELTAVLPGDELVGPGTPRTTRAVSIAASRAAVWPWLIQIGEDRGGFYSYSLLERAVGADMHNADSIHPEWQQVRVGDTVWLARRYGPDARQIVAAVKRYSHLVLVNPADYERVLCGQRAAGCWSFILRRDVDGTRLLARGSGGAVGHFWFDIPHFVMEQKMLRGIARRAAGRHRQPDVLRGYPPWVSGNSVR
>NZ_LT549889.1|WP_162295778.1|91765_91960_-|hypothetical-protein
MAITDTMVRQGPMTRAKLLVLETDCGSVFISLSFSPATSGHPIATASASSKPAMKSTVLRAGAA
>NZ_LT549889.1|WP_087019408.1|92567_92849_+|DUF1876-family-protein
MTEDEHTVRKDWTVQIAIDEYDGRTRATATLRGGDRETTGIGLARCNPADPDIADIGDELAVARALAALVQQLRTSTVHDIEESTHQPVTALR
>NZ_LT549889.1|WP_087031539.1|92910_93858_+|universal-stress-protein
MSGERPAGTPGGAQNRSPGILVGIDGSASSTSAVRWAAREALLRKLPLQIVHVMKWPSGPIWAEVLATRDIAADLTRSGTAILHAAQQVAEEVIGGAVEIRVDDVVAAESVVGVLVDRSRLARMVVVGRRGTGAVSRLLMGSVTSALIRYAHNPVVVVHGADAESLPAPDTAPVVVGMDGSPTSENALAFAFDEASRRGAPLVVVHAWGDVEGEPLPGSQWEQLRVLAEERVAERLAGWGEQYPDVLVHRDVVLDRPAHHLLQQSPTAQLTVVGSRGRGGFKGLLLGSVSKSVVEGAQTPVVVVPPDGSRGSENR
>NZ_LT549889.1|WP_087019411.1|93873_94152_+|DUF1918-domain-containing-protein
MKANVGDWLVIKGSVVDRPDQRGLITEVHSSDGSPPYVVRWLDTDHIATVFPGSDAIVVTAEEQKDADERARHRFGVIQSTIQRNQSTGEGT
>NZ_LT549889.1|WP_087019414.1|94338_94623_+|hypothetical-protein
MHWHEYDMGWWGYAGMGIGMVLFWTLLIAAGAALFIVLVGDRRRPPTPPMPPPPPMPVHQTPEQILAARFARGEIGESEFRDRLAVLQNHQESG
>NZ_LT549889.1|WP_162295784.1|95104_96202_+|4Fe-4S-dicluster-domain-containing-protein
MNGVVIDAAGLRNLVSALIDRGYRVIGPTLSGNAIELAELTAAEDLPRGWGVDVGPGHYRLRRRGDSALFGHSAGPQSWKQFLHPPRQRLWSSAEPVVEQPERLAFIGVRACDLAAIAVLDGVLGAAAHPDRGFRGRLSDTFVVAVNCTEPGGLCFCASMGTGPRVGPGYDLALTERITDDSPYYLVEVGSEEGAQVLAVLDHRDARPDEIDSASADVDAAARQMGRQMPARDLRELLVESRESPHWDEVADRCLTCGNCTMVCPTCFCTSVEDVTDLTGGHAERWLEWSSCFDVDFTFIHGGNVRQSAPSRYRHWITHKLGTWHDQFGSSGCVGCGRCIAWCPTGIDITQEMTTLAELAEHRDD
>NZ_LT549889.1|WP_087019418.1|96194_97043_+|FAD/NAD(P)-binding-protein
MTDTARTAASAMTPTPYRVCSRADENRECSTLHLSPVDAALGTPGPGEFMMMYVFGVGEIAVSVSGVPGAPDTTLVHTVRAVGAVSTALREAQVGTVIGMRGPFGTGWELRDTTGRDLILVAGGVGLAPLRPVVLAVLADRTAHARVTLIAGARSREEFLFGAELREWSRGRMIGVQLTVDIPMQGWSGEVGLVTEPLRRLALRPEKTTAFLCGPESMMRSCAEELLRKGVSAGDIRVSLERNMQCAVGWCGHCQLGPLLLCRDGPVVGYDVAGPLLAVREL
>NZ_LT549889.1|WP_087019421.1|97043_97802_+|oxidoreductase
MNTPSLAVWKFASCDGCQLTLLDCEDQLLTLADQVRIVTFLEASSVVATGPYDISLVEGSITTETDRLRILEIRRQSTTLVTIGACATAGGIQALRNMADAEEFASVVYARPDYIDTLATSTPAAAHVEVDYQLQGCPIDRGQLLDTLAALLIGRKPRLPARTVCSECKLRGVTCVLVAESIPCLGPVTQAGCGALCPSCHRGCYGCFGPAATPDTAALIPLLRRDGLSEAGVEQVFSTFNVTRFAAERNDR
>NZ_LT549889.1|WP_087019424.1|97798_99091_+|Ni/Fe-hydrogenase-subunit-alpha
MSREVRTLSVGALTRVEGEGALHVTLRDGVLDSVELNIYEPPRFFEAFLRGRAHTEPPDLTARVCGICPVAYQVSACNAIEDACGVSIDPELVDLRRLMYCGEWIHSHALHIFLLHAPDFLGYPDGISLARDRPRLIERGLAVKKAGNRLMEVIGGRAIHPVNVRLGGFYSVPRKSDLKPVAEQLRRALDDAVRTVAEVAEFDCPDLEFDHEFLALTGTGRYPIENGHIARSAGATFPVADFTRHVAETQVRHSTALHATLDGGRYLTGPLARYSLNSAALSPVARRAAADAGLGPQCRNPFRSIVVRAVEVVYALDEALRIITDYQRPVRPFVPVPARAGVGHGVSEAPRGLLFHRYELGDDGLVRSATIIPPTAQNQGAIEHEMAELVAANLGCDDSALTALCERSIRNHDPCISCAAHFLTVSVDHR
>NZ_LT549889.1|WP_087019427.1|99087_99573_+|hydrogenase-maturation-protease
MNGEVLVIGIGNDLRGDDGVGLVVAAALADRRTPGVRVMTTAGDPATIIDAWVGVGLVIVVDAAMGDVATSGRLRRWVPAEMAGIAEVSSHGLGLLQAYGLGEALGRLPARVVVFTVDIAEAGHGIGLSPPIGAAVPRAVAAVLTEVRDRRRRRRTETVDR

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Crispr_ID: NZ_LT549889_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LT549889_2

4538555-4538651

Orphan

Consensus_repeat	Method
TGCGGGTGACGGTGGCCGCCCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_LT549889_2

>merge|NZ_LT549889|2|4538555-4538651|CRISPRCasFinder
TGCGGGTGACGGTGGCCGCCCCGCACGAGAACGACGCGTTCCTGGCCTTCGCCCGGAAGTGGATCTCCCGGTGATGCGGGTGACGGTGGCCGCCGCG

>NZ_LT549889|2|2|4538555-4538651|CRISPRCasFinder
TGCGGGTGACGGTGGCCGCCCCG	CACGAGAACGACGCGTTCCTGGCCTTCGCCCGGAAGTGGATCTCCCGGTGA
TGCGGGTGACGGTGGCCGCCGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LT549889.1\|WP_087028256.1\|4539099_4539909_+\|crotonase/enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl\|CDD\|235714
NZ_LT549889.1\|WP_087028237.1\|4526989_4528288_-\|MCE-family-protein	unknown	unknown	gnl\|CDD\|273384
NZ_LT549889.1\|WP_087028268.1\|4544623_4545460_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224057
NZ_LT549889.1\|WP_087028261.1\|4541648_4542620_+\|NAD(P)H-quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|176180
NZ_LT549889.1\|WP_087028240.1\|4528299_4529559_-\|MCE-family-protein	unknown	unknown	gnl\|CDD\|273384
NZ_LT549889.1\|WP_087028250.1\|4534102_4535158_-\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176190
NZ_LT549889.1\|WP_087028272.1\|4546353_4547184_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224596
NZ_LT549889.1\|WP_087028245.1\|4530603_4532037_-\|MCE-family-protein	unknown	unknown	gnl\|CDD\|378749
NZ_LT549889.1\|WP_087028266.1\|4544113_4544617_+\|bacterial-proteasome-activator-family-protein	unknown	unknown	gnl\|CDD\|378489
NZ_LT549889.1\|WP_087028258.1\|4539932_4540949_-\|linear-amide-C-N-hydrolase	unknown	unknown	gnl\|CDD\|238885
NZ_LT549889.1\|WP_087032781.1\|4532042_4532873_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223838
NZ_LT549889.1\|WP_087028270.1\|4545452_4546367_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|224137
NZ_LT549889.1\|WP_087028248.1\|4532893_4533661_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223838
NZ_LT549889.1\|WP_162295914.1\|4535225_4536458_-\|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl\|CDD\|239551
NZ_LT549889.1\|WP_162295915.1\|4536619_4536772_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LT549889.1\|WP_087028274.1\|4547203_4548004_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_LT549889.1\|WP_087028243.1\|4529555_4530584_-\|MCE-family-protein	unknown	unknown	gnl\|CDD\|273384
NZ_LT549889.1\|WP_087028263.1\|4542638_4543835_-\|cysteine-desulfurase-like-protein	unknown	unknown	gnl\|CDD\|273906
NZ_LT549889.1\|WP_087028235.1\|4525853_4526993_-\|MCE-family-protein	unknown	unknown	gnl\|CDD\|273384
NZ_LT549889.1\|WP_162295916.1\|4541094_4541607_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670

Protein	Function_ID	Function_description	E-value
NZ_LT549889.1\|WP_087028256.1\|4539099_4539909_+\|crotonase/enoyl-CoA-hydratase-family-protein	gnl\|CDD\|235714	PRK06142, PRK06142, crotonase/enoyl-CoA hydratase family protein.	4.26689e-169
NZ_LT549889.1\|WP_087028237.1\|4526989_4528288_-\|MCE-family-protein	gnl\|CDD\|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	9.43203e-71
NZ_LT549889.1\|WP_087028268.1\|4544623_4545460_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224057	COG1134, TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	5.47764e-117
NZ_LT549889.1\|WP_087028261.1\|4541648_4542620_+\|NAD(P)H-quinone-oxidoreductase	gnl\|CDD\|176180	cd05276, p53_inducible_oxidoreductase, PIG3 p53-inducible quinone oxidoreductase. PIG3 p53-inducible quinone oxidoreductase, a medium chain dehydrogenase/reductase family member, acts in the apoptotic pathway. PIG3 reduces ortho-quinones, but its apoptotic activity has been attributed to oxidative stress generation, since overexpression of PIG3 accumulates reactive oxygen species. PIG3 resembles the MDR family member quinone reductases, which catalyze the reduction of quinone to hydroxyquinone. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	8.85248e-162
NZ_LT549889.1\|WP_087028240.1\|4528299_4529559_-\|MCE-family-protein	gnl\|CDD\|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	4.35847e-67
NZ_LT549889.1\|WP_087028250.1\|4534102_4535158_-\|NADP-dependent-oxidoreductase	gnl\|CDD\|176190	cd05288, PGDH, Prostaglandin dehydrogenases. Prostaglandins and related eicosanoids are metabolized by the oxidation of the 15(S)-hydroxyl group of the NAD+-dependent (type I 15-PGDH) 15-prostaglandin dehydrogenase (15-PGDH) followed by reduction by NADPH/NADH-dependent (type II 15-PGDH) delta-13 15-prostaglandin reductase (13-PGR) to 15-keto-13,14,-dihydroprostaglandins. 13-PGR is a bifunctional enzyme, since it also has leukotriene B(4) 12-hydroxydehydrogenase activity. These 15-PGDH and related enzymes are members of the medium chain dehydrogenase/reductase family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES.	1.62181e-166
NZ_LT549889.1\|WP_087028245.1\|4530603_4532037_-\|MCE-family-protein	gnl\|CDD\|378749	pfam11887, Mce4_CUP1, Cholesterol uptake porter CUP1 of Mce4, putative. Mce4_CUP1 is a family of putative Mce4 transporters of cholesterol. The domain is found associated with pfam02470. The full TCDB classification for this family in conjunction with PF02470 is TC:3.A.1.27.4.	8.02901e-105
NZ_LT549889.1\|WP_087028266.1\|4544113_4544617_+\|bacterial-proteasome-activator-family-protein	gnl\|CDD\|378489	pfam10759, DUF2587, Protein of unknown function (DUF2587). This is a bacterial family of proteins with no known function.	5.13704e-90
NZ_LT549889.1\|WP_087028235.1\|4525853_4526993_-\|MCE-family-protein	gnl\|CDD\|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	4.3997e-70
NZ_LT549889.1\|WP_087032781.1\|4532042_4532873_-\|ABC-transporter-permease	gnl\|CDD\|223838	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	7.93762e-69
NZ_LT549889.1\|WP_087028270.1\|4545452_4546367_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	2.13615e-52
NZ_LT549889.1\|WP_087028248.1\|4532893_4533661_-\|ABC-transporter-permease	gnl\|CDD\|223838	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	6.51024e-75
NZ_LT549889.1\|WP_162295914.1\|4535225_4536458_-\|Rieske-2Fe-2S-domain-containing-protein	gnl\|CDD\|239551	cd03469, Rieske_RO_Alpha_N, Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable microorganisms to tolerate and even exclusively utilize aromatic compounds for growth. ROs consist of two or three components: reductase, oxygenase, and ferredoxin (in some cases) components. The oxygenase component may contain alpha and beta subunits, with the beta subunit having a purely structural function. Some oxygenase components contain only an alpha subunit. The oxygenase alpha subunit has two domains, an N-terminal Rieske domain with an [2Fe-2S] cluster and a C-terminal catalytic domain with a mononuclear Fe(II) binding site. The Rieske [2Fe-2S] cluster accepts electrons from the reductase or ferredoxin component and transfers them to the mononuclear iron for catalysis. Reduced pyridine nucleotide is used as the initial source of two electrons for dioxygen activation.	4.31127e-39
NZ_LT549889.1\|WP_087028272.1\|4546353_4547184_+\|ABC-transporter-permease	gnl\|CDD\|224596	COG1682, TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	8.33431e-66
NZ_LT549889.1\|WP_087028274.1\|4547203_4548004_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	7.3884e-16
NZ_LT549889.1\|WP_087028243.1\|4529555_4530584_-\|MCE-family-protein	gnl\|CDD\|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	4.07646e-71
NZ_LT549889.1\|WP_087028263.1\|4542638_4543835_-\|cysteine-desulfurase-like-protein	gnl\|CDD\|273906	TIGR01976, am_tr_V_VC1184, cysteine desulfurase family protein, VC1184 subfamily. This model describes a subfamily of probable pyridoxal phosphate-dependent enzymes in the aminotransferase class V family (pfam00266). The most closely related characterized proteins are active as cysteine desulfurases, selenocysteine lyases, or both; some are involved in FeS cofactor biosynthesis and are designated NifS. An active site Cys residue present in those sequences, in motifs resembling GHHC or GSAC, is not found in this family. The function of members of this family is unknown, but seems unlike to be as an aminotransferase. [Unknown function, Enzymes of unknown specificity].	4.7377e-140
NZ_LT549889.1\|WP_087028258.1\|4539932_4540949_-\|linear-amide-C-N-hydrolase	gnl\|CDD\|238885	cd01902, Ntn_CGH, Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that inhabit the gut. CGH has an N-terminal nucleophilic cysteine, as do other members of the Ntn hydrolase family to which CGH belongs.	1.25823e-127
NZ_LT549889.1\|WP_162295916.1\|4541094_4541607_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	3.51091e-15

>NZ_LT549889.1|WP_162295915.1|4536619_4536772_-|hypothetical-protein
MTISIAVQRKSDIDGLTGAVAWCAVRGQQDPKSAMNATGPAGAAPGRPRN
>NZ_LT549889.1|WP_162295914.1|4535225_4536458_-|Rieske-2Fe-2S-domain-containing-protein
MTIESTMSTGELAAETRRALTLRHIEHVRAGTTDAHPDGVRVIPASEYLDPEIAAAERALMHTVPLVAAMSSELAGPRSYRTEMLFDVPVLLVRQDDGSVKAFLNSCSHRGARLLEGAGEVGKRISCSYHAWTYAPSGELKSVTQPSKFGKVDLCGNGLVELPCAERYGLIFVLLDAKAEMDIDGFLGDFGPQLALCNLDTFTTADERTLPHEVNWKLALCGYLESYHVKVVHAKTLAAAFIGNVSTHDAFGPDGRHFRTTWSMNEVVQMAEAEDVDAVLDGLQYAPYNTVLYLYPNTVITAPDFIGIRFINRLFPGHQPHDQMTHYRTMIPAYMTDDERAMVEPFQQVTRTAVEEEDYGQVPGINKAIRSGLRDSLLVGENEPTVTEMHRVMARALGRPNPDQPVTSGA
>NZ_LT549889.1|WP_087028250.1|4534102_4535158_-|NADP-dependent-oxidoreductase
MTVNKQVRLAKRPVGRADESTWEITTEPIPEPGDGEFAVRVEYISLDPAMRGWIGEVPTYVAPVELGAVMRAHAVGRVYASRHPEYEVGQMVSGMFGVCEYAVSDGRTDVMHVDESLAPAPAWLGALGFPGLTAYFGLLDVGKMKPGDTVLISGAAGAVGSIAGQIAKLSGCRVIGVAGGPEKCAWLTDELGYDVAIDYKAGSIGKALRAAAPKGIDVYFDNVGGEVLESALGHLRRGARIALCGGISSYNATDPQPGPSRYMQLLMKRASLTGFIVFDFARRYPEAYAALGHWIRRGDVVTHEQVETGGIEAYGRTMNMLFDGANTGKLVLQVGDGLAGAAPVAAQAAGN
>NZ_LT549889.1|WP_087028248.1|4532893_4533661_-|ABC-transporter-permease
MIATDDLLRPFRGIGAFFAMSVDTFVQMFKPPFAWREFLTQSWFVARVSLLPTLMLSIPFTVLLVFTFNILLIEFGAGDYSGTGAAYGTVTQLGPVVTVLVIAGAGATAMCADLGARTIREELDALRVMGIDPIQALVVPRVLAATFVAVLLSSVVILVGIAGGFFFSVFVQDVTPGAFAGGMTIITGLADVVTALIKAGLFGLAAGLIACYKGTSVKGGPAGVGNAVNETVVYTFVALFAINILASTVSVEATL
>NZ_LT549889.1|WP_087032781.1|4532042_4532873_-|ABC-transporter-permease
MFPRLERRVRRWYGGWIKLGVQTQFFVETVVSIGEVFRRYRTELLRLIAQMGLGTGALAVIGGTVVIVGFLTLTTGALVAVQGYNQFSQVGVEALTGFASAYFNVRLIAPLTAGIGLAATIGAGATAQLGAMRINEEIDALEVMGIRSVAYLASTRVIAGIIVVIPLYCVAILMSFFAARFGTTSVYGQSSGVYDHYFNTFLSPTDLIWSFFLAVTMAVVIMLVHTYYGFTAAGGPAGVGEAVGRAVRTSLVASALAVLLVSLAIYGQSGNFNLSG
>NZ_LT549889.1|WP_087028245.1|4530603_4532037_-|MCE-family-protein
MENKSLYARVHPALWSVFLVVVVAAAVLFSAGLFAGTFRTFVPVTLTSDRAGLVMESGAKVKMLGVQVGRVAAIEGGRHPVSLKLDIFPDQAAAIPSNVLAEIRATTAFGAKYVELIPPEKPSQTGLKAGAVLQSRNVSTEVNTVFQSLMGVLDRIDPAKLNAVLSAFAEGVRGQGERIGQATTDANEVLLAVNPRMGQVAENFRSLKGFGDTYSAAASDILSTMDAASTTSATITGKAAELDALLLSVIGFSRSAKGILEPNKENLVNAVNILEPTTDLLHKYDPSYTCLLVGTKFFLDNGGYRAFGGNGRTEIADAALHFGKDPYKFPEHLPIVAAKGGPDGKPGCGSLPYTHLNFPVRQLITNTGWGTGIDIRPNPGIGSPFWVNWLPTTRAVPEKPSVRGDGPPAIGPVPYPGAPPYGAPLFGPDGAPLWAGPPPGAPPPPVPGVPNPPAPYGTGVGPNPGPPQQDSAPGETG
>NZ_LT549889.1|WP_087028243.1|4529555_4530584_-|MCE-family-protein
MRDKLSGVIWRLGIFVVVCLLGTFALLTLFAQLRFQKETTYRADFTNVSGLQAGDFVRIAGVEVGKVKNITLNERRSAVVEFTADDTVVLTEGSEAAVRYDNPIGGRFLELREGAGPVQRLAPGEMIPQDRTEPALDLDALIGGFRPLFRALDPEQVNLLTGQLIDAFQGQGATISSFLSQTATLTDTLADRDVLIGQVIGNLDSVLGSLGDQGDQFAKAVDSLSELVEGLAERKTDISDAIRYTSAVSGSVADMLGQAREPLKNVVTQSDRVSGLVVADHEYVDNLLNTLPDAYQRLARQGMHGDYFSYYICDLVLKVNGKGGQPVYVKLASQNTGRCAPK
>NZ_LT549889.1|WP_087028240.1|4528299_4529559_-|MCE-family-protein
MKHFSERNPAIIGVIGVALTAAVTVGALQYKRLPFFDTGTEHSAYFAEAGGLKTGAAVQVAGLRVGEVESVDLDGASVVVTFKVDNGVDLGDRAEAAVKTKSLLGAKILEITPRGEGHLTEAIPLDRTTSAYQLPDALGDLADTIGGLHTDQLNESLTTLAQTFQNTAPDLQAAVAGAARFSQTLNERDAQLRGLLENANNVTGILAERTDQVVGLIVDSNALLAQLRTQSSALDQFSGDISALSRQVSGLVADNRETLRPALDKFNGAVAIVEGRKERIQKAIKLLNSYAMSLGESVASGPYFKAILANVLPGQFIQPFVDAAFSDLGLDPNVLLPTERIDPAVGQKATPALPIPFPRTGQGGEPRLTVPDAITGNPGDARYPYREPLPAPAPGGPPPGPPPLPPVTESPTPTDGAQQ
>NZ_LT549889.1|WP_087028237.1|4526989_4528288_-|MCE-family-protein
MNLRVALAIAVVVSVVAGVVVAVRMVPTIGRTHVVAYFANSNGIFPGDEIRVLGVPVGEIDTIEPQPDRAKISFWVNGKYKLPADVQAVIISPQLVSARAIQLTPVFTGGPEFPDNGVIPEERTAVPVEWDDFREQLQTLTDTLQPTGAEGVSPLGGFINTAANNLRGQGADIRDTLGKLAQAFSALGDHSTDIFDTMRNLSILVTALKSSTDLMGQLNGNLATVTSLLANDHDEFGQAISDIYAAAGDVEGFVAENREALGTSSDKLASLTTAVDESLGDIKQALHVLPNALQNFVNIFQPGNAAATGILAVNNFANPISFLCGALQAASRLNAEQSAKLCVQYLAPIIKNRQYNFPPIGLNPVVGTMARPNEVTHSEDWMRPDFRPAPPPASAPLAAESDAIAEAAQPGPPPTDPAAGLPGLMVPAGAGS
>NZ_LT549889.1|WP_087028235.1|4525853_4526993_-|MCE-family-protein
MIARMSRRAVSAAALLMLAAGLSGCGWRGVNSLPLPGTEGGGPGSYQVQAQLPQVTNLERNSRVRVGDVTVGNVSNIERQGWHALVTMTLNGNVDLPANATVRIGQTSLLGTLHIELAPPDDEAPKGKLQNGSLIPLENDASYPTTEQTLAAVSMLFNGGGLGQVHDITRAFSTAFKGREQDMRSFLEQLNLFVGELDGQKHDIIAATDSLNAVSGQFAAQRPIVDKALQTIPDALAVINDERGDLTEAFAEFGDFSEMAADAVNRSKDNVVRELQDVGPVLKSLADAGPSMTRSLSYLSTYPFPKETIENWVRGDYVNLTGVFDLTLSRIDAAMFTGTRFEGKLTELEMRWGRTIGQLPSPYTAGNPLIVPYHMNQGS
>NZ_LT549889.1|WP_087028256.1|4539099_4539909_+|crotonase/enoyl-CoA-hydratase-family-protein
MAYESVTVDIADHVARVTLIGPGKGNAMGPAFWAEMPDVFGTLDADPEVRAIVLTGSGKNFSYGLDLITMGASLPGLDSGAKGRLDFHKKIAKMQEAISAVADCRTPTIAAIQGWCIGGGVDLISAVDIRYASSDAKFSVREVKLAIVADVGSLARLPLILSDGHLRELALTGKDIDAARAEKIGLVNDVYDDADATLAAAHETAAQIAANPPLTVHGVKDVLDQQRIGRVSESLRYVAAWNSAFLPSKDLGEAVTAMFQKRPPQFTGE
>NZ_LT549889.1|WP_087028258.1|4539932_4540949_-|linear-amide-C-N-hydrolase
MCTRVIWPDAGNAVLVGRNMDFHKDLMTNLWKQPRGVKRDDGVSGKLQWTSKYGSVIATAFDIISVDGLNEAGLAGHVLWLAESTFGTPDPDRTQLSQAIWLQYFLDNFGTVAEAVAWVEQTDVQVVQMDDPTGGKPPAIHLALDDATGDSAIIEYIDGKAKVYHDRDYRVMTNSPTFDQQLELVKAFDGLGGSDPLPGSTVATDRFARASYYVSRLPEPAGQVEAIAGMFSVIRNAAQPFRIPDPGKPDASQTIWQVVLDLTNRRYVYESTTRPNIVWVDLADLDFSEGSPQLKLDLIGELAVQGGIAGNVSGRFEDKGPMTFLSLQLLAQLASAKG
>NZ_LT549889.1|WP_162295916.1|4541094_4541607_-|MarR-family-transcriptional-regulator
MEAIIGGRTASTMPGLDIAEQKSWQNFLDSALRLYATLNRSLVDAHGLALNDVRLLDILDTSDSGSARMGDLAEGLMSLPSRVTRQIHRLEKLQLVTRVASPDDRRGVLATITDEGRALLAEARTTYSAGVRSHYLGRLSRSQITATGENCRRISAGLQANGRPAKLGRV
>NZ_LT549889.1|WP_087028261.1|4541648_4542620_+|NAD(P)H-quinone-oxidoreductase
MRAIIALSTERMTWQEVPDVAAHEGEVVIKVVAAGVNRADLLQAGGSYPPPPGASDTLGLEVSGTIAEVGPGVAGWSVGQPVCALLAGGGYAEYVAVPAAQVLPVPDGVGLVEAAALPEVACTVWSNLMMTARLRPGALLLIHGGASGIGTHAIQLARALGTRVAVTAGSAEKLAVCAELGAEMLINYRDEDFAERVRGAGGADVIFDIMGAKYLDRNIDALADGGRLVIIGMQGGVKAELNIGKLLGKRAGVLATALRSRPVDGPDGKGAIVEQVTANVWPLIAEGRIRPIIGAELPVEQAAEAHRLLRESAVTGKVLLRVG
>NZ_LT549889.1|WP_087028263.1|4542638_4543835_-|cysteine-desulfurase-like-protein
MAYDVARVRGLHPSLGDGWAHLDAQNGMLLPDSVATTVSTAFRGSKPITAGPHPAARRSATVLAAARQAVADFVGADPEGVVLGADRAVLLTSLADAASVRVGLGYEIVLSRLDDEANIAPWLRAANRYGAKVKWAEVDIETGELPGYQWEGLITPPTRLAAITSASATLGTITDLTPVTKLVHENNGLVIVDHSAAAPYRMIDIDDIDADVVALNAVAWGGPPIGALVFRDPAVIEQFSSVSLDPHARGPARLETGIHQYGLLGGVVASIEYLANLDEAATGSRRERLAMSMESAAIYLDRLFNYLLASLRSLPRVLVLGSPAERIPVLSLVVDGVPAERVIQRLADNGVLVGHSEHSRVLDALGVDDIGGAITVGLSHYSTAAEIDQLVRVLASLG
>NZ_LT549889.1|WP_087028266.1|4544113_4544617_+|bacterial-proteasome-activator-family-protein
MTINPDDDDNVEILTGGAADESADDDKALTDLIEQPAKVMRIGTMIKQLLEEVRAAPLDEASRSKLAQIHSSSIRELEEGLAPELREELERLTLPFSDEAVPSDSELRIAQAQLVGWLEGLFHGIQTALFAQQMAARAQLEQMRQLPPGMAPPGQRGPGHPGTGQYL
>NZ_LT549889.1|WP_087028268.1|4544623_4545460_+|ABC-transporter-ATP-binding-protein
MSNEPFISTENAWVEFPIFDAKSRSLKKAFLGKAGGTIGRNESNVVVIEALRDITMNLRMGDRVGLVGHNGAGKSTLLRLLSGIYEPTRGSATVRGRVAPVFDLGVGMDPEISGFENIIIRGLFLGQTRKQMLAKVDEIADFTELGDYLSMPLRTYSTGMRVRLAMGVVTSIDPEILLLDEGIGAVDAEFMKKARTRLQNLVARSGILVFASHSNEFLAQLCKTAMWVDHGTIKMTGGIEEVVGAYEGPDAARHVREVLAENARGDESLARRADNTDA
>NZ_LT549889.1|WP_087028270.1|4545452_4546367_+|glycosyltransferase-family-2-protein
MPESVTAVVVTHRRVAELSVSLQAVCGQTRPPDHLIVVDNDDDPAVRELVAAQPVASTYLGSRRNLGGAGGFALGMLHALSLGSDWVWLADDDGRPGDPNVLATLLACAAKHSLSEVSPMVCDLDDPTRLAFPLRRGLAWRRHVSELKVDGSDDLLPGIASLFNGALFRAEALEAVGVPDLRLFIRGDEVDVHRRLVLSGLRFGTCLDAVYLHPQGSDEFKPILGGRMHTQYPSDEVKRFYTYRNRGYLQAQRGLGRLIPQEWLRFGWFFLVTRRDPAGLRDWLRLRRLGRQEKFERFKKHDDS
>NZ_LT549889.1|WP_087028272.1|4546353_4547184_+|ABC-transporter-permease
MTILDAAAQSKTMARAWGDLRAGFNKRELWLHLGWQDIKQRYRRSVLGPFWITIATGTMAVALGGLYSKLFKLELAEHLPYVTLGLIIWNLINAAIIEGADVFVANEGLIKQLPTPLSVHVYRLVWRQVLLFAHNIIIFVIIAIIFPQHWTWTSLAFIPALALIVANCVWVALVFGILATRYRDISPLLFSLVQLLFYMTPIIWNDATLRQQGAEGWAKIIEFNPLLHYVDIVRAPLLGADQELRHWIVVLVCTLVGWICAAFAMRQYRARVPYWV
>NZ_LT549889.1|WP_087028274.1|4547203_4548004_+|alpha/beta-fold-hydrolase
MGISLTAPDGTELVAEVTGSGPPVVFVHGSNGGLDSWADIGARLTGYQVVRYARRNHPPSGTGPAPNSFAVEAGDLQAVLASVGRAHVVGGSYGATVALHAALADSSLIASLALFEPPLLQSGPHLAPVVEQYQRLYVTVRYADALELFLREAAQMPAELISGGAPIPDDLMAAMSALADLEAMAGDTDDIGRWGAIDLPVLLMQGGLSWPPLPEGMDRLAAVLPRAERVVWPDQSHFATATAPDAVAAALQSFLDARAGRSDLAT

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Crispr_ID: NZ_LT549889_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LT549889_3

5740684-5740771

Orphan

Consensus_repeat	Method
CGGCACTCTGATGACCAATGTCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_LT549889_3

>merge|NZ_LT549889|3|5740684-5740771|CRISPRCasFinder
CGGCACTCTGATGACCAATGTCTTGATCGTGGAAGATTTCGCGGCCCGCGCGATGACGGAAGGCACGGCACTCTGATGACCAATGTGC

>NZ_LT549889|3|3|5740684-5740771|CRISPRCasFinder
CGGCACTCTGATGACCAATGTCT	TGATCGTGGAAGATTTCGCGGCCCGCGCGATGACGGAAGGCA
CGGCACTCTGATGACCAATGTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LT549889.1\|WP_173826755.1\|5745414_5746233_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LT549889.1\|WP_087030732.1\|5731508_5732015_-\|DUF2505-domain-containing-protein	unknown	unknown	gnl\|CDD\|378476
NZ_LT549889.1\|WP_087030781.1\|5748209_5749055_+\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007
NZ_LT549889.1\|WP_087030787.1\|5749886_5750738_+\|pyrroline-5-carboxylate-reductase	unknown	unknown	gnl\|CDD\|237008
NZ_LT549889.1\|WP_087030745.1\|5735410_5736718_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NZ_LT549889.1\|WP_087030764.1\|5742343_5743252_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_LT549889.1\|WP_087030735.1\|5732013_5733096_+\|UDP-N-acetylmuramate-dehydrogenase	unknown	unknown	gnl\|CDD\|237552
NZ_LT549889.1\|WP_087030779.1\|5747223_5748210_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236766
NZ_LT549889.1\|WP_087030738.1\|5733162_5734425_+\|L,D-transpeptidase-family-protein	unknown	unknown	gnl\|CDD\|380079
NZ_LT549889.1\|WP_087030742.1\|5734421_5735180_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|226674
NZ_LT549889.1\|WP_162295946.1\|5736742_5738065_+\|D-inositol-3-phosphate-glycosyltransferase	unknown	unknown	gnl\|CDD\|132490
NZ_LT549889.1\|WP_087030752.1\|5738602_5739343_+\|phosphoglyceromutase	unknown	unknown	gnl\|CDD\|184519
NZ_LT549889.1\|WP_173826754.1\|5744472_5745159_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_LT549889.1\|WP_057170115.1\|5750876_5751107_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|200128
NZ_LT549889.1\|WP_087030748.1\|5738061_5738589_+\|YbjN-domain-containing-protein	unknown	unknown	gnl\|CDD\|371210
NZ_LT549889.1\|WP_162295947.1\|5746246_5747227_+\|Ppx/GppA-family-phosphatase	unknown	unknown	gnl\|CDD\|223326
NZ_LT549889.1\|WP_087030729.1\|5730714_5731530_-\|SAM-dependent-methyltransferase	unknown	unknown	unknown
NZ_LT549889.1\|WP_087030784.1\|5749051_5749858_+\|thioesterase-family-protein	unknown	unknown	gnl\|CDD\|379298
NZ_LT549889.1\|WP_087030768.1\|5743261_5744485_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_LT549889.1\|WP_087030757.1\|5739462_5740629_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|274368

Protein	Function_ID	Function_description	E-value
NZ_LT549889.1\|WP_087030732.1\|5731508_5732015_-\|DUF2505-domain-containing-protein	gnl\|CDD\|378476	pfam10698, DUF2505, Protein of unknown function (DUF2505). Members of this family are all Actinobacteria. The function is not known.	5.27306e-50
NZ_LT549889.1\|WP_087030781.1\|5748209_5749055_+\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	3.60547e-32
NZ_LT549889.1\|WP_087030787.1\|5749886_5750738_+\|pyrroline-5-carboxylate-reductase	gnl\|CDD\|237008	PRK11880, PRK11880, pyrroline-5-carboxylate reductase; Reviewed.	7.91892e-99
NZ_LT549889.1\|WP_087030745.1\|5735410_5736718_+\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	4.47776e-34
NZ_LT549889.1\|WP_087030764.1\|5742343_5743252_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	0.000273884
NZ_LT549889.1\|WP_087030735.1\|5732013_5733096_+\|UDP-N-acetylmuramate-dehydrogenase	gnl\|CDD\|237552	PRK13903, murB, UDP-N-acetylmuramate dehydrogenase.	9.33736e-178
NZ_LT549889.1\|WP_087030779.1\|5747223_5748210_+\|hypothetical-protein	gnl\|CDD\|236766	PRK10811, rne, ribonuclease E; Reviewed.	2.43721e-05
NZ_LT549889.1\|WP_087030738.1\|5733162_5734425_+\|L,D-transpeptidase-family-protein	gnl\|CDD\|380079	pfam17964, Big_10, Bacterial Ig domain. This entry represents a bacterial Ig-like domain found associated with transpeptidase domains.	1.24613e-72
NZ_LT549889.1\|WP_087030742.1\|5734421_5735180_-\|SDR-family-oxidoreductase	gnl\|CDD\|226674	COG4221, COG4221, Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only].	3.78594e-85
NZ_LT549889.1\|WP_162295946.1\|5736742_5738065_+\|D-inositol-3-phosphate-glycosyltransferase	gnl\|CDD\|132490	TIGR03449, mycothiol_MshA, D-inositol-3-phosphate glycosyltransferase. Members of this protein family, found exclusively in the Actinobacteria, are MshA, the glycosyltransferase of mycothiol biosynthesis. Mycothiol replaces glutathione in these species.	0
NZ_LT549889.1\|WP_087030752.1\|5738602_5739343_+\|phosphoglyceromutase	gnl\|CDD\|184519	PRK14120, gpmA, phosphoglyceromutase; Provisional.	0
NZ_LT549889.1\|WP_173826754.1\|5744472_5745159_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.75534e-37
NZ_LT549889.1\|WP_057170115.1\|5750876_5751107_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|200128	TIGR01764, Probable_excisionase, DNA binding domain, excisionase family. An excisionase, or Xis protein, is a small protein that binds and promotes excisive recombination; it is not enzymatically active. This model represents a number of putative excisionases and related proteins from temperate phage, plasmids, and transposons, as well as DNA binding domains of other proteins, such as a DNA modification methylase. This model identifies mostly small proteins and N-terminal regions of large proteins, but some proteins appear to have two copies. This domain appears similar, in both sequence and predicted secondary structure (PSIPRED) to the MerR family of transcriptional regulators (pfam00376). [Unknown function, General].	3.16303e-17
NZ_LT549889.1\|WP_087030748.1\|5738061_5738589_+\|YbjN-domain-containing-protein	gnl\|CDD\|371210	pfam10722, YbjN, Putative bacterial sensory transduction regulator. YbjN is a putative sensory transduction regulator protein found in Proteobacteria. As it is a multi-copy suppressor of the coenzyme A-associated temperature sensitivity in temperature-sensitive mutant strains of Escherichia coli the suggestion is that it both helps CoA-A1 and possibly works as a general stabilizer for some other unstable proteins. This family was expanded to subsume other related families: DUF1790, DUF1821 and DUF2596.	3.76216e-21
NZ_LT549889.1\|WP_162295947.1\|5746246_5747227_+\|Ppx/GppA-family-phosphatase	gnl\|CDD\|223326	COG0248, GppA, Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism].	1.10262e-98
NZ_LT549889.1\|WP_087030784.1\|5749051_5749858_+\|thioesterase-family-protein	gnl\|CDD\|379298	pfam13622, 4HBT_3, Thioesterase-like superfamily. This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.	2.2844e-47
NZ_LT549889.1\|WP_087030768.1\|5743261_5744485_+\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.62538e-33
NZ_LT549889.1\|WP_087030757.1\|5739462_5740629_+\|ATP-binding-protein	gnl\|CDD\|274368	TIGR02966, Phosphate_regulon_sensor_protein_PhoR, phosphate regulon sensor kinase PhoR. Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems].	3.59467e-76

>NZ_LT549889.1|WP_087030757.1|5739462_5740629_+|ATP-binding-protein
MSVGSALLLAAVLALLALGLGVALGRVLSGRSARGQGTSESGVITLSQMLLHIVTVTPTGVVVVDGLRDVVYMNDQATRLGLVRDRLLDDAAWEAVQRCLDTGEDVEIDLSPRKRQNPGRSGLVVRGLVRLLVEGDHRFAVVFVNDQSETARLEATRRDFVANVSHELKTPVGAMSVLAEALLASTDDPENVRRFAEKMVVESNRLADMIGELIELSRLQGAEPLPQLDSVDVDSVVAEALSRYKVAADNADIAITTDAPSGFRVLGDERLLVTALANLVSNAIAYSPNGTTVSISRRRRGNDVEIAVTDRGIGIAKADQERVFERFFRVDKARSRATGGTGLGLAIVKHVAANHNGSIRIWSQPGTGSTFTLSIPAIHDAPDEEGSA
>NZ_LT549889.1|WP_087030752.1|5738602_5739343_+|phosphoglyceromutase
MANLILLRHGESQWNEKNLFTGWVDVDLTDKGRKQAVRGGELIAEQGVLPDVLYTSLLRRAITTANLALDAADRHWIPVHRDWRLNERHYGALQGLDKSETLAKYGEEQFMAWRRSYDTPPPPIDKGSEYSQDADPRYADIDGGPLTECLADVVARFVPYFEQTIVPDLKAGKTVLIAAHGNSLRALVKYLDGMSDADVVSLNIPTGIPLLYELDDNLKPTVAGGRYLDPEAAAAGAAAVAAQGTK
>NZ_LT549889.1|WP_087030748.1|5738061_5738589_+|YbjN-domain-containing-protein
MSSGTDQVTKLIEQTLQDNELEYAHHQGAGGGLPGLVVALPGERRLKTNTILGIGEHSVRVEAFVCRRPDENHEAVYRFLLKRNRRLYGVAYTLDNLGDIYLVGWMAHTSVTPDEIDRILGQVLEAVDADFNTLLELGFRSSIQKEWEWRVARGESLTNLQAFEHLIGQDDESGA
>NZ_LT549889.1|WP_162295946.1|5736742_5738065_+|D-inositol-3-phosphate-glycosyltransferase
MRAVSEPSALLDTARRVAVLSVHTSPLAQPGTGDAGGMNVYVLQTALELARRGVEVEIFTRATSSADAPLVQFAPGVLVRNVVAGPFEGLDKNDLPTQLCAFTAGVLRAEATQEPGYYDIVHSHYWLSGQVGWLAADRWAVPLVHTAHTLAAVKNAALADGDAPEPALRSVGEQQVVDEADRLIVNTEIEAQQLVSLHNADRRSIDVVHPGVDLSVFTPGDKASARAALGIEAREKVVAFIGRIQPLKAPDVLLRAAAKLPDVTVVIAGGPSGSGLAAPDSLVRLADELGISARVRFLPPQSRAELVNVYRAADIVAVPSYSESFGLVAVEAQACGTPVVAASVGGLPVAVRDGISGSLVDGHDPGDWAHAIDALFARDPETMRAAAVAHAGTFSWAHTVDALLTSYGHAITDYQDKHPRREQTGRRTGRRFALRRGVRA
>NZ_LT549889.1|WP_087030745.1|5735410_5736718_+|ROK-family-protein
MSTATTLRSTSAAAHAKRAVSPASGRYPQARKLNIVAPSLKVADVAAASVFGAARQRGPIARDAIARVTGLSIATVNRQVTALLDAEVLRERADLAVSGAIGRPRVPVEVNHEPFLTLGLHIGARTTSIVATDLFGRTLDVVETPTPRGSQNAALASLAGSARRYLSRWHRRRALWVGVAAGGVVDSTSGYLDHARLGWSQAPVGPVLAETLGLPVSLASHVDAMAGAELLLGVRRPSAQTGTSLYVYARETVGYALSIGGRVHSPSSGPGTIAALPVSSELLGGTGKLESTVSDEAVLTAARAQRIIPAEGPASTLTAVLRAARGGHQGARALLAERARVLGEAVALLRDMLNPDDLVVGGQAFTEYPEGMELVEQAFSARTVLGPRDIRVTAFGNRVQEAGAGVVSLGALYADPIAAMRRAQQRRETGVLGAS
>NZ_LT549889.1|WP_087030742.1|5734421_5735180_-|SDR-family-oxidoreductase
MSTPTEQRRVAVVTGASAGIGEATAKTLAGLGFHVICVARRKEPIEALAAEIGGTAIVADVTDPAAVAALAEQLNRVDVLVNNAGGARGLESVADADIEHWRWMWEANVLGTLHVTKALLGKLIDSGDGLIVTVTSIAAHEVYDNGSGYTSAKHAQGVLHRTLRSELFGKPVRLTEVAPGMVKTDFSLNRFEGDSGRADKVYQGVTPLVAEDIAEVIGFVASRPSHVDLDLIVVRPRDQVTGAAGSRVHRQV
>NZ_LT549889.1|WP_087030738.1|5733162_5734425_+|L,D-transpeptidase-family-protein
MLGLGGAGFLAACAGTGPIGGAPESEEPAAAPTITLEPDDATDDVVPTAPVGATVRDGWFQRIALINAAGKAVAGRLNRDRTEFTITEPLGYGGTYTWSGSVVGRDGEAVPVTGTLRTVDPQTTVNGRFQLADHQTVGVAAPIILQFDASIAEEDRATVEKALKVTTTPEVEGSWAWLPDEAAGSRVHWRTREYYPPGATVHVDADLYGVSFGDGMYGAADSTLDFTIGRRQVVKADAASHRIQVITDEGVIMDFPCSYGEGDLDRNVTRSGVHVVTEKYEDFYMTNPAAGYANLRERFAVRISNNGEFIHANPASSGAQGNSNVTNGCINLSLEDAESYFHTAMYGDPVEVTGTRIQLSYADGDIWDWAVPWEEWKSMSALSDAEPPADIPETAPVTPSDAPTLSGIPTTTTPAPAPGG
>NZ_LT549889.1|WP_087030735.1|5732013_5733096_+|UDP-N-acetylmuramate-dehydrogenase
MSATLPLASVAGPNFAGAAVTENAPLAELTTLRVGPVAARLITCDSTAELAAVAAALPVADDVVVLAGGSNVVMADDLTGLTVIAVANTGIRVDGAVLRAEAGAVWDDVVATSLEHGLGGLECLSGIPGSAGATPIQNVGAYGAEVADTITAVRLLDRSTGVDEWVRPDRLGFGYRHSVLKYQSARIVLEVEFTLDPAGRSAPLRYGELATALGAQPGDTADPARVRAAVLALRGAKGMVLDAGDHDTWSVGSFFTNPVVAPEVYQRLAAREPGRVPNYPAPDGVKLAAGWLVERAGFGKGYPGPDAPAALSSKHALALTNRGTAGTADVLALARTVRDGVRDRFGIELTPEPVLIGCAL
>NZ_LT549889.1|WP_087030732.1|5731508_5732015_-|DUF2505-domain-containing-protein
MPRSYDMAAHYPCSVAEVYGAFADKAYWLERLEKSGCDAVSLDTLTVRDDGGLDIGTTQTVRFHQLPGFVSALHRGDLTLVRRETWSPVRDGRAEATISGSVPGAPVQVGGTAELTSTASGARADVHATVQVKIPLVGGRVEEFIGGQLAEMIRLEEEFTSAWISDRA
>NZ_LT549889.1|WP_087030729.1|5730714_5731530_-|SAM-dependent-methyltransferase
MDQRPGLKPVGLPTRGTTGYNRLRRSDRWLVHSPRVRAALLAAADPLVVDLGYGALPVTTLELAARLRTVRADLRVVGLEIHPERVATAQRSAAAGVEFALGGFELAGLRPVLVRAFNVLRQYPVTEVDAAWAQLRGRLAAGGLVVDGTCDELGRLCCWVLLDADGPVSLTLACDPFAIERPSDLAERLPKVLIHHNVAGQPIHALLQAADRAWATAAGHGVFGPRVRWRAMLEQLRDEGFPVDPPRRRVRDGVLTVPWSAVSPPPRFEEP
>NZ_LT549889.1|WP_087030764.1|5742343_5743252_+|CPBP-family-intramembrane-metalloprotease
MNASPTDQSNRWGNPIVSALRESPAQRRRGVRWFLAIAFLGAWLPWLGVYLLGGSLDDPLTQLAVAAFVPAIAACVVRRWITRQGFADSGLALHWRSAWPYCLAAVTMPWGVLLLALVISIPVGLWSPSDLAMTTNSWAYLAVGPLICLASAPIFWGEEYGWTAYLRDRLVPGRPVATTFLTGLIWGVWHWPLPWVGYFGGGTSVSEAIWSMLWWLPLSILLEFVIGWLWSATGSVWPGAMLHAGSNLVASVGMLYVLGDTVGINTTTLLLCAGLLPFVAVIVLTGHTGGTRTNRRTAGLQA
>NZ_LT549889.1|WP_087030768.1|5743261_5744485_+|sensor-histidine-kinase
MVHAPARSLIAAMVSGPRYLVSSWPWRALAWTLFGGGLSVVVIIAMAPVFVLGASRSLRTALWSPLLEAECARLSLIDEAASQRIRRELAAAGTEQRLPGVRQVSYVLFTALIAGPCGTVLVAFLVILTGVLLAAPWLVAPGEPINVAVWLIDTPREAWAATIFGAAIMVAATYIVGAYAGVVGKLAVAALTDSQALQREVARLEDSRTALLHAVEQERRRIESDLHDRVQHRLVALALTLGIAENIHGDDETGRLAADAHRQLDDSLAELRSVLLGILPRALTEHGLTAAVTDLIGPYPLPATTDFGKTETPQRLPAAIEHTAYSVINEALTNIVKHASATSVAITADRQDGMWWMTIRDNGRGGAAIQTGRGLATLAARVEAIDGTLAICSPAGGPTEVRMRCPA
>NZ_LT549889.1|WP_173826754.1|5744472_5745159_+|response-regulator-transcription-factor
MPRMTSQRVGGLRVVLAEDAPLLRTGIVTVLESDGFQVCAAVDTADDLREAVRVYDPDIVITDVRMPPTHTDEGIRIAIELRRNAPGLPVVILSQYTSVGSLHQLLDRNVDTGRGGLGYLLKDRVAHVRHFLDAVRDIAAGATLIDPEIVIALVGDSRRRGVLATLTPREEEVLGFMAQGLTNPQIAQRLVVSEAAVRKHVGGIFAKLPLSGDGDRRVLAVLAYLNET
>NZ_LT549889.1|WP_173826755.1|5745414_5746233_-|hypothetical-protein
MGLPLTTVSTSRVGSVGGIGGEVELDFAREWVEFYDPENPKHLIKADMTWLLSRWTCVFGTPACQGTVAGRPDDGCCSHGAFLSDDDDRAMLDDAVKKLTAEDWQYREKGLGRKGYLEEDEYDGQPNLRTRKYKGACIFLNRPGFAGGIGCALHSKALKLGVEPLTMKPEVCWQLPIRRTQEWVTRPDGSEILKTVITEYDRRGWGEGGADLHWYCTGDPAAHVGERPVWQSYEPELTELLGDKAYAELAAMCKRRGQLGLVAVHPATRAAE
>NZ_LT549889.1|WP_162295947.1|5746246_5747227_+|Ppx/GppA-family-phosphatase
MRLGVLDVGSNTVHLLVVDARRGGHPTPMSSTKAALRLAEAVDSSGKLTRRGADKLVETVDEFAKIATSSGCAELMAFATSAVRDATNSEDVLARVQAETGVALKVLSGVDESRLTFLAVRRWYGWSAGRIINIDIGGGSLELSSGVDEEPEVAMSLPLGAGRMTREWLTEDPPGRRRVAMLRDWLTTELSEAGAVMQNAGTPDLAVATSKTFRSLARLTGAAPSGAGPRVKRELTATGLRQLIAFISRMTTADRAELEGVSAERAPQIVAGALVAEASMRALGLETVQICPWALREGLILRKLDSEADGTALVESTPATPKGNIR
>NZ_LT549889.1|WP_087030779.1|5747223_5748210_+|hypothetical-protein
MTEPSENTATRPISVAELLAKNGNIGAPAPGGRRRRRRGNADAVTVAELTGEIPIIRLDDTPEPAVAEAPTVEDTPVVEPADETGVDETGPDETGVDETRVDETKNDEARADEAEAAPVEAVTDEAVTDEAETVEADAPVEPEPAPRRHAHLLKKQHGPHAAAVGAEEMTFDPLLDDEDEHDAETAVESASYLKSPSDTLFGGDSMADDAARRDAQDDTQRVALHLDEPLDEADGSGLPAEQSAFMHGFWIVVQSVLAVALGAGLFIAFDQLWKWNNIVALALSVLVILGLVVGVRVVRKTEDIASTLIAVAVGAMVTLGPLALLQST
>NZ_LT549889.1|WP_087030781.1|5748209_5749055_+|sugar-phosphate-isomerase/epimerase
MRPAIKVGLSTASVYPLRIEAAFELAARLGYDGVELMVWAEPASQNVAAVEELSRRYGIPVLSVHAPCLLISQRVWGADPIAKLGRSVRAAEQLGAQTVVVHPPFRWQRRYAERFSDLVAELEDGSDVMVAVENMFPFRADRLWGTGLPSIERMRKRGGKPGPAISAFAPSYDPLDGGHAHFTLDLSHSATAGTDALEMAERMGAGLVHLHLCDGSGASTDEHLVPGRGTQPAAQICRQLAASDFTGHVILEVTTSGARTATEREVLLTESLQFAREHLLR
>NZ_LT549889.1|WP_087030784.1|5749051_5749858_+|thioesterase-family-protein
MTVLFSDAMRLEPAGGGVYHGVLDEHWTIGPKVHGGAMLALCANAARAELAETGTEPLVVSGNFLWAPDPGALQVVTTVRKRGRRISLVDVELKQGDRVAVRAAITLGEPEHDAPPLLSTNPVVPLMTPEPPPGLEPIGPGHPMADIVHLAHGCDIRPSLTTMEPRSDGGPPVIEYWVRPRVGSPDVLFALLCGDVSAPVTYGVSRFGWAPTVQLTAFLRARPADGWLRVLCTTTQIGQEWFDEDHVVVDAGGRIVVQTRQLALVPAT
>NZ_LT549889.1|WP_087030787.1|5749886_5750738_+|pyrroline-5-carboxylate-reductase
MARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAEKNPDRARQLAETYSVLVTSVADAAESATYIVIAVKPADVESVTAEIADAVSKAEGESEEQVFVSVAAGVSTAFYEAKLPAGAPVVRVMPNAPMVVGGGVSALAGGRFATPEQLKEVSAIFDTVGDVLAVAEQQMDAVTAVSGSGPAYFFLMVEALVDAGVDAGLSREVSTELVVHTMAGSAALLLDRRDANPPGVMDTSAAALRAVVTSPGGTTAAGLRELERGGLRSAVSDAVRAAKMRSEQLGITSE
>NZ_LT549889.1|WP_057170115.1|5750876_5751107_+|helix-turn-helix-domain-containing-protein
MTSLNGPSARDSAGDGQPKAQFLTVAEVASLMRVSKMTVYRLVHNGELPAVRVGRSFRVHAKAVHDLLETSYFDAG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_LT549889_1	1.1\|90694\|23\|NZ_LT549889\|CRISPRCasFinder	90694-90716	23	NZ_LS974446	Rhizobium selenitireducens ATCC BAA-1503 isolate T2.30D-1.1_plasmid plasmid 1, complete sequence	52872-52894	2	0.913

1. spacer 1.1|90694|23|NZ_LT549889|CRISPRCasFinder matches to NZ_LS974446 (Rhizobium selenitireducens ATCC BAA-1503 isolate T2.30D-1.1_plasmid plasmid 1, complete sequence) position: , mismatch: 2, identity: 0.913

cgactaggcaccaccacgactcg	CRISPR spacer
caactatgcaccaccacgactcg	Protospacer
*.**** ****************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

4273096 : 4340656

Tupanvirus(26.67%)

protease,tRNA,holin

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_087027789.1\|4273096_4275622_-\|protease	ATP-dependent protease ATP-binding subunit ClpC	K4FB40	Cronobacter_phage	4.7e-129	39.6
WP_073856857.1\|4275940_4276282_-	Lsr2 family protein	A0A160DEV0	Gordonia_phage	3.9e-15	45.7
WP_087032707.1\|4276389_4277889_-\|tRNA	lysine--tRNA ligase	A0A2K9KZX5	Tupanvirus	1.1e-72	36.1
WP_087027790.1\|4277937_4278741_-	type III pantothenate kinase	NA	NA	NA	NA
WP_087027792.1\|4278743_4279160_-	aspartate 1-decarboxylase	NA	NA	NA	NA
WP_087027793.1\|4279159_4280095_-	pantoate--beta-alanine ligase	NA	NA	NA	NA
WP_087027795.1\|4280091_4281015_-	DUF2520 domain-containing protein	NA	NA	NA	NA
WP_087027797.1\|4282384_4282870_-	DUF3180 domain-containing protein	NA	NA	NA	NA
WP_087027799.1\|4282869_4283382_-	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase	NA	NA	NA	NA
WP_087027801.1\|4283378_4283762_-	dihydroneopterin aldolase	NA	NA	NA	NA
WP_087032711.1\|4283754_4284567_-	dihydropteroate synthase	S4VNV0	Pandoravirus	5.7e-20	32.7
WP_087032709.1\|4284602_4285220_-	GTP cyclohydrolase I FolE	E7DN69	Pneumococcus_phage	7.3e-44	53.4
WP_162295907.1\|4285236_4287522_-\|protease	ATP-dependent zinc metalloprotease FtsH	E5EQU5	Bathycoccus_sp._RCC1105_virus	2.0e-107	46.0
WP_173826731.1\|4287677_4288613_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_087027804.1\|4288609_4289830_+	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_087027806.1\|4289829_4290846_+	zinc-binding dehydrogenase	NA	NA	NA	NA
WP_162296005.1\|4290859_4291720_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_087027811.1\|4291741_4292941_-	CoA transferase	NA	NA	NA	NA
WP_087027813.1\|4293055_4293793_+	SIMPL domain-containing protein	NA	NA	NA	NA
WP_087032718.1\|4293858_4294434_-	hypoxanthine phosphoribosyltransferase	A0A1V0SEQ1	Hokovirus	6.0e-08	27.7
WP_087027814.1\|4294456_4295413_-\|tRNA	tRNA lysidine(34) synthetase TilS	NA	NA	NA	NA
WP_087032715.1\|4295391_4296612_-\|protease	zinc-dependent metalloprotease	NA	NA	NA	NA
WP_087027816.1\|4296608_4297985_-	D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase	NA	NA	NA	NA
WP_087027818.1\|4298051_4298540_+	inorganic diphosphatase	A0A2H4J8U1	uncultured_Caudovirales_phage	1.9e-31	44.5
WP_087027820.1\|4298621_4299143_+	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	NA	NA	NA	NA
WP_087027821.1\|4299158_4300331_+	serine hydrolase	NA	NA	NA	NA
WP_087027822.1\|4300294_4301158_-	DUF2236 domain-containing protein	NA	NA	NA	NA
WP_087027824.1\|4301342_4301987_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_087027826.1\|4301973_4302447_-	nitroreductase family deazaflavin-dependent oxidoreductase	NA	NA	NA	NA
WP_162295908.1\|4302456_4304058_-	aldehyde dehydrogenase family protein	NA	NA	NA	NA
WP_087027828.1\|4304085_4304484_-	hypothetical protein	NA	NA	NA	NA
WP_087027830.1\|4304608_4308496_+	non-ribosomal peptide synthetase	A0A2K9L3I8	Tupanvirus	1.6e-35	25.7
WP_087027832.1\|4308492_4309833_+	M1 family metallopeptidase	A0A2K9L1R3	Tupanvirus	1.3e-21	24.4
WP_087027834.1\|4311059_4311644_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_087027836.1\|4311646_4313422_-	amidohydrolase family protein	NA	NA	NA	NA
WP_087027838.1\|4313542_4314526_+	UDP-glucose 4-epimerase GalE	A0A2K9L5H6	Tupanvirus	9.3e-41	34.1
WP_087032723.1\|4316393_4316768_+	carboxymuconolactone decarboxylase family protein	NA	NA	NA	NA
WP_087027840.1\|4316820_4317180_+	hypothetical protein	NA	NA	NA	NA
WP_087027842.1\|4317187_4317541_+	hypothetical protein	NA	NA	NA	NA
WP_087027844.1\|4317651_4318863_-	DNA polymerase III subunit delta'	NA	NA	NA	NA
WP_087027846.1\|4318943_4320512_+	adenylate/guanylate cyclase domain-containing protein	A0A1B1IWY2	uncultured_Mediterranean_phage	2.3e-17	30.7
WP_087027848.1\|4320486_4323309_-	type I DNA topoisomerase	J3E777	Acanthamoeba_polyphaga_lentillevirus	8.7e-100	35.0
WP_087027850.1\|4323420_4324002_-	hypothetical protein	NA	NA	NA	NA
WP_006243848.1\|4324075_4324279_-	cold-shock protein	A0A1X9IGI9	Lactococcus_phage	1.5e-14	56.2
WP_087027852.1\|4324565_4326914_+	DEAD/DEAH box helicase	NA	NA	NA	NA
WP_087027854.1\|4327189_4328275_+	DUF5593 domain-containg protein	NA	NA	NA	NA
WP_087032725.1\|4328271_4328580_-	flp pilus-assembly TadE/G-like family protein	NA	NA	NA	NA
WP_087027856.1\|4328599_4328896_-	pilus biosynthesis protein TadE	NA	NA	NA	NA
WP_087027859.1\|4328919_4329123_-	DUF4244 domain-containing protein	NA	NA	NA	NA
WP_087027861.1\|4329135_4329693_-	type II secretion system F family protein	NA	NA	NA	NA
WP_087027863.1\|4329689_4330472_-	type II secretion system F family protein	NA	NA	NA	NA
WP_087027865.1\|4330468_4331635_-	TadA family conjugal transfer-associated ATPase	NA	NA	NA	NA
WP_087027867.1\|4331631_4332687_-	AAA family ATPase	NA	NA	NA	NA
WP_087027872.1\|4333147_4334023_+	HAD-IB family hydrolase	NA	NA	NA	NA
WP_087027874.1\|4334413_4335151_-	oxidoreductase	NA	NA	NA	NA
WP_087027876.1\|4335246_4337220_+	acetate--CoA ligase	A0A2H4PQU7	Staphylococcus_phage	1.0e-78	38.0
WP_157923192.1\|4337241_4337883_-\|protease	serine protease	NA	NA	NA	NA
WP_087027879.1\|4338015_4338516_+\|holin	phage holin family protein	NA	NA	NA	NA
WP_087027881.1\|4338527_4339478_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_087027883.1\|4339465_4340656_-\|protease	acid resistance serine protease MarP	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_LT549889

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection