CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_LT604076	Streptococcus thermophilus strain ACA-DC 2 chromosome I	3 crisprs	DEDDh,cas9,cas1,cas2,csn2,DinG,cas6,cas10,csm2gr11,csm3gr7,csm4gr5,csm5gr7,cas3	1	2	6	1

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_LT604076_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LT604076_1

760733-760839

Orphan

Consensus_repeat	Method
CATATCATGCATATTGTCCATAT	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_LT604076_1

>merge|NZ_LT604076|1|760733-760839|CRISPRCasFinder
CATATCACCCATATGCATCATGTGTCCTCCATGATTCATCATATCATGCATATTGTCCATATCATGCATATTGTCCATATTGTGCATGTTGTGCATATTGTCCATAT

>NZ_LT604076|1|1|760733-760839|CRISPRCasFinder
CATATCACCCATATGCATCATGT	GTCCTCCATGATTCAT
CATATCATGCATATTGTCCATAT	CATGCATATTGTCCATATTGTG
CATGTTGTGCATATTGTCCATAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LT604076.1\|WP_087009860.1\|755225_755372_+\|C69-family-dipeptidase	unknown	unknown	gnl\|CDD\|335383
NZ_LT604076.1\|WP_011681063.1\|757004_757205_+\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_LT604076.1\|WP_087009867.1\|765115_766300_+\|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|181076
NZ_LT604076.1\|WP_087009859.1\|752438_753329_+\|RNase-adapter-RapZ	unknown	unknown	gnl\|CDD\|235450
NZ_LT604076.1\|WP_087009869.1\|770421_771309_+\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|227309
NZ_LT604076.1\|WP_011225850.1\|764182_765094_+\|cysteine-synthase-family-protein	unknown	unknown	gnl\|CDD\|107204
NZ_LT604076.1\|WP_087009862.1\|756518_756725_+\|cold-shock-domain-containing-protein	unknown	unknown	gnl\|CDD\|278729
NZ_LT604076.1\|WP_087009870.1\|773795_775340_+\|zinc-ABC-transporter-substrate-binding-protein-AdcA	unknown	unknown	gnl\|CDD\|238499
NZ_LT604076.1\|WP_087009863.1\|757537_758713_+\|IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NZ_LT604076.1\|WP_011225860.1\|775554_775953_+\|hypothetical-protein	unknown	unknown	unknown
NZ_LT604076.1\|WP_157659033.1\|755394_755976_+\|C69-family-dipeptidase	unknown	unknown	gnl\|CDD\|335383
NZ_LT604076.1\|WP_023909583.1\|751687_752458_+\|DUF1003-domain-containing-protein	unknown	unknown	gnl\|CDD\|377629
NZ_LT604076.1\|WP_087009865.1\|761160_762336_-\|IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NZ_LT604076.1\|WP_087009861.1\|755982_756219_+\|C69-family-dipeptidase	unknown	unknown	gnl\|CDD\|335383
NZ_LT604076.1\|WP_087009871.1\|777897_778905_-\|YeiH-family-putative-sulfate-export-transporter	unknown	unknown	gnl\|CDD\|225411
NZ_LT604076.1\|WP_011681073.1\|780771_781680_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_LT604076.1\|WP_087009872.1\|781887_783696_+\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NZ_LT604076.1\|WP_002945081.1\|754296_755208_+\|DNA-binding-protein-WhiA	unknown	unknown	gnl\|CDD\|224398
NZ_LT604076.1\|WP_014621467.1\|753325_754300_+\|YvcK-family-protein	unknown	unknown	gnl\|CDD\|211689
NZ_LT604076.1\|WP_087009868.1\|769310_769943_-\|N-6-DNA-methylase	unknown	unknown	gnl\|CDD\|280533

Protein	Function_ID	Function_description	E-value
NZ_LT604076.1\|WP_087009860.1\|755225_755372_+\|C69-family-dipeptidase	gnl\|CDD\|335383	pfam03577, Peptidase_C69, Peptidase family C69.	1.36054e-22
NZ_LT604076.1\|WP_011681063.1\|757004_757205_+\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	3.84731e-33
NZ_LT604076.1\|WP_087009867.1\|765115_766300_+\|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl\|CDD\|181076	PRK07671, PRK07671, bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase.	0
NZ_LT604076.1\|WP_087009859.1\|752438_753329_+\|RNase-adapter-RapZ	gnl\|CDD\|235450	PRK05416, PRK05416, RNase adapter RapZ.	9.37929e-170
NZ_LT604076.1\|WP_087009869.1\|770421_771309_+\|EamA-family-transporter	gnl\|CDD\|227309	COG4975, GlcU, Putative glucose uptake permease [Carbohydrate transport and metabolism].	1.85597e-116
NZ_LT604076.1\|WP_011225850.1\|764182_765094_+\|cysteine-synthase-family-protein	gnl\|CDD\|107204	cd01561, CBS_like, CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.	4.60053e-143
NZ_LT604076.1\|WP_087009862.1\|756518_756725_+\|cold-shock-domain-containing-protein	gnl\|CDD\|278729	pfam00313, CSD, 'Cold-shock' DNA-binding domain.	6.51173e-14
NZ_LT604076.1\|WP_087009870.1\|773795_775340_+\|zinc-ABC-transporter-substrate-binding-protein-AdcA	gnl\|CDD\|238499	cd01017, AdcA, Metal binding protein AdcA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AdcA proteins belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. They are comprised of two globular subdomains connected by a long alpha helix and they bind their ligand in the cleft between these domains. In addition, many of these proteins have a low complexity region containing metal binding histidine-rich motif (repetitive HDH sequence).	9.40469e-123
NZ_LT604076.1\|WP_087009863.1\|757537_758713_+\|IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	3.54579e-179
NZ_LT604076.1\|WP_157659033.1\|755394_755976_+\|C69-family-dipeptidase	gnl\|CDD\|335383	pfam03577, Peptidase_C69, Peptidase family C69.	2.25912e-112
NZ_LT604076.1\|WP_023909583.1\|751687_752458_+\|DUF1003-domain-containing-protein	gnl\|CDD\|377629	pfam06210, DUF1003, Protein of unknown function (DUF1003). This family consists of several hypothetical bacterial proteins of unknown function.	1.65528e-47
NZ_LT604076.1\|WP_087009865.1\|761160_762336_-\|IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	9.38185e-179
NZ_LT604076.1\|WP_087009861.1\|755982_756219_+\|C69-family-dipeptidase	gnl\|CDD\|335383	pfam03577, Peptidase_C69, Peptidase family C69.	8.86379e-35
NZ_LT604076.1\|WP_087009871.1\|777897_778905_-\|YeiH-family-putative-sulfate-export-transporter	gnl\|CDD\|225411	COG2855, COG2855, Predicted membrane protein [Function unknown].	1.92787e-85
NZ_LT604076.1\|WP_011681073.1\|780771_781680_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	9.86371e-34
NZ_LT604076.1\|WP_087009872.1\|781887_783696_+\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NZ_LT604076.1\|WP_002945081.1\|754296_755208_+\|DNA-binding-protein-WhiA	gnl\|CDD\|224398	COG1481, COG1481, Uncharacterized protein conserved in bacteria [Function unknown].	2.5038e-125
NZ_LT604076.1\|WP_014621467.1\|753325_754300_+\|YvcK-family-protein	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	4.28998e-144
NZ_LT604076.1\|WP_087009868.1\|769310_769943_-\|N-6-DNA-methylase	gnl\|CDD\|280533	pfam02384, N6_Mtase, N-6 DNA Methylase. Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.	2.71304e-73

>NZ_LT604076.1|WP_087009863.1|757537_758713_+|IS256-family-transposase
MTQFTTELLNFLAQKQDSDEFFRTSLETAMNDLLQAELSAFLGYEPYDKLGYNSGNSRNGSYARKFETKYGTVQLSIPRDRNGNFSPALLPAYGRRDDHLEEMVIKLYQTGVTTREISDIIERMYGYHYSPTTISNISKATQENVATFHERSLEANYSVLFLDGTYLPLRRGTVSKECIHIALGITPEGQKAVLGYEIAPNENNASWSTLLDKLQNQGIQQVSLVVTDGFKGLEEIINQAYPLAKQQRCLIHISRNLASKVKRADRAVILEQFKTIYRAENLEMAVQILENFIAEWKPKYRKVMESLENTDNLLTFYQFPYQIWHSIYSTNLIESLNKEIKRQTKKKVLFPNKEALERYLVTLFEDYNFKQNQRIHKGFGQCADTLESLFD
>NZ_LT604076.1|WP_011681063.1|757004_757205_+|cold-shock-protein
MANGTVKWFNATKGFGFITSEDGQDLFAHFSSIQSDGFKSLDEDQKVEFDVEVGQRGPQAVNITKA
>NZ_LT604076.1|WP_087009862.1|756518_756725_+|cold-shock-domain-containing-protein
MNKGTINWFNADKGYGFIMADDMQDVFAYLISIQGNDFKKYDEGQSQKVTFDIKMTSRGRYDSNVHKR
>NZ_LT604076.1|WP_087009861.1|755982_756219_+|C69-family-dipeptidase
MNPEKDYDLKSFFIPWCQKPYRKITVEDVKYVLSLHYQDTPYDPYGPQGYAMSLRQFRPIGINRTSQTALLQMCPNKI
>NZ_LT604076.1|WP_157659033.1|755394_755976_+|C69-family-dipeptidase
MICQISPLRYTSVPDALGKDGIWGGAGINSANVAMSATETITTNARVLGADHLVKDDFGEEDMLTLVLPYIKTVREGVLHLGELLETYGTYESNGIAFADTEEIWWLKTIGGHNWIARRVPDDAYVTNPNQLGIDHYEFENPDDYLASPDIRDFINKHHLDLTYSNEHFNPRYAFGSQRDKDHHYNTPRARAM
>NZ_LT604076.1|WP_087009860.1|755225_755372_+|C69-family-dipeptidase
MACTTILVGRKASYDGSTMMARTEDSQSGVFTPKEFLVITPEDQLRHY
>NZ_LT604076.1|WP_002945081.1|754296_755208_+|DNA-binding-protein-WhiA
MSFTIKVKEEIIAASSKDIAELSALIKMSGSVGLTNQGLTLSISTENAKIARHIYQLIENRYRCNPELRHYNKTNLKKNRVYTVFVAENVNDILSDLQLADSFFGFETGIETSIMEDDDAGRSYLRGAFLATGTVRDPEKGRYQLEIFSVYQDHAEDLASLMKKFMLDAKVLQHKNGFVTYLQKAEDIMDFLIVIGAMTSKEIFEEVKIMRETRNDLNRANNAETANIARTISASMKTINNIIKIMDTVGLEILPVELRQIAQLRIANPDYSIQQIADSIEPPLTKSGVNHRLRKINKIADDL
>NZ_LT604076.1|WP_014621467.1|753325_754300_+|YvcK-family-protein
MKKPRITVIGGGTGIPVILRSLRHKDVDITAVVTVADDGGSSGNLRNIMKLTPPGDLRNVLVAMSDMPKLYERVFQYRFDQTDGALAGHPLGNLIIAGISEMQGSTYNAMQLLTKFFHVTGKIYPASETALTLHAVFQDGHEVAGESSISQYDGMIERVYVTNAYNEDVPKASRKVVDAIMNSDMIVLGPGSLYTSILPNLVIPEIRQALIETKADVTYICNIMTQYGETEHFSDADHVAVLNRHLGSDVIDNVLVNVKKVPQEYMASNEFDEYLVQVEHDFEGLRREAKTIVSSNFLRLENGGAFHHGDLVAEELMHLVRKKS
>NZ_LT604076.1|WP_087009859.1|752438_753329_+|RNase-adapter-RapZ
MKTKIINLVVVTGMSGAGKTVAIQSFEDIGYFTIDNIPPSLVPKVIELLKHSEETDKIALVVDMRSRVFFDEINDILDQLESNEELNFKILFLDATDGELVSRYKETRRSHPLAADGRVLDGIKLERELLSPLKSLSQNVVDTTKLTPRQLRKAISEQFSSKQDQSSFRIEILSFGFKYGLPLDADLVFDVRFLPNPYYDPTLRNLTGLDKEVYDFVMTHKESEDFYKNLNHLIKPILPGYQKEGKSVLTIAVGCTGGQHRSVAFAHRLAQDLKNDWTVNETHRDKDRRKETVNRS
>NZ_LT604076.1|WP_023909583.1|751687_752458_+|DUF1003-domain-containing-protein
MKVKRVQDYISKDWFDETDGSYFERLNSRLQVLLRKDYPDLKGDDFISNISLLDYRLVFLDEVIADANEKNKHVRETVHDVTKGLLYEDKDVQEQLDSRITFGQKVADEVARFGGSWIFILSFIAFMGIWMVLNVVQPFGIAFDKYPFILLNLALSTLAAVQAPLIMMSQNRASDYDRLQARNDYHVNKQSKEEIRLLHEKIDHLVQQDQSDLLTIQKLQTEMLMAVSQQVEKLSDDIRILKVMRLERGTHEDKDN
>NZ_LT604076.1|WP_087009865.1|761160_762336_-|IS256-family-transposase
MTQFTKELLNFLAQKQDIDEFFRTSLETAMNDLLQAELSAFLGYEPYDKLGYNSGNSRNGSYARKFETKYGTVQLSIPRDRNGNFSPALLPAYGRRDDHLEEMVIKLYQTGVTTREISDIIERMYGYHYSPTTISNISKATQENVATFHERSLEANYSVLFLDGTYLPLRRGTVSKECIHIALGITPEGQKAVLGYEIAPNENNASWSTLLDKLQNQGIQQVSLVVTDGFKGLEEIINQAYPLAKQQRCLIHISRNLASKVKRADRAVILEQFKTIYRAENLEMAVQILENFIAEWKPKYRKVMESLENTDNLLTFYQFPYQIWHSIYSTNLIESLNKEIKRQTKKKILFPNEEALERYLVTLFEDYNFKQNQRIHKGFGQCADTLESLFD
>NZ_LT604076.1|WP_011225850.1|764182_765094_+|cysteine-synthase-family-protein
MLIHSISELIGHTPLIDLQINIPNHSHIYAKLEMFNPGGSIKDRLGQYMIQDAINRGQVTEGVTTIIEPTAGNTGIGIALAAQQHHLPTILVVPEKFSFEKQQLMKALGAKIINTPSDQGIKGAIEKAEALHNQTPNSFVPMQFKNPANPDTYYHTLAQELLDDLNDPIDAFVAGAGSGGTFAGVARYLKEHNPATQTIVVEPEGSILNGGPAHPHRTEGIGVEFVPPFFKDVQIDKTLTIADADAFHQVKELAKKQGLFIGSSSGAALAASLKVAKALPENSTIVTIFPDSSERYMSENIYD
>NZ_LT604076.1|WP_087009867.1|765115_766300_+|aminotransferase-class-V-fold-PLP-dependent-enzyme
MEFDTKLIHGGISEDKATGAVSVPIYMASTFHQQKIGENQYEYSRSGNPTREAVEKLIAELEGGTAGFAFASGSAAIYTVFSMFSAGDHFVIGNDVYGGTFRLIDAVLKRFGMTFTVVDTRDLAAVEEAITPNTKAIYLETPTNPLLRVTDIAAVAKIAKLHQILSIIDNTFSSPYVQRPLEQGVDIVLHSASKYLGGHSDVIAGLVVTKDDQLAEKIGYLQNAIGGILAPQESWLLQRGIKTLSLRMRAHLANAEAVFNYLSNQPLVSKIYYPGDPNNPDYEVAKKQMHGFGAMISFELQDGLDPKQFVEQLHVITLAESLGALESLIEIPALMTHGSIPRDIRLKNGIKDELIRLSVGVEDQKDLLADLESGFNELKSSEKNISDSKVHSQA
>NZ_LT604076.1|WP_087009868.1|769310_769943_-|N-6-DNA-methylase
MFELGLSIKCDIDDPRFREYGIAPKTKAEDSFLSHCLYHTKESGRVAITLPHGVLFRGAAEGRIPKALIDKHQIESVIGFPDKLFLNTGIPVCVLILKKNRANSDILFVDASQGFEKMKNQKQLRPEDIYKITETVIHRKAVDKYSHLATLEEVIENDYNLNIPRYVDTFEEEEPIDLADIQGQIDEVDAEIAKANQTLANHFKELGVLK
>NZ_LT604076.1|WP_087009869.1|770421_771309_+|EamA-family-transporter
MQGVLFALVPLFAWGSIGLVANKLGGDANQQTLGMTLGAFVFALIVSLFRMPTLTWQIFLIGFIGGLFWVIGQFGQFNSMKYMGVSVASPLSSGSQLVFGVLLGVFAFHEWTKQIQFIIGFIAMALLVVGFYFSAKRDPENAVVKEGRNYTKGLIALTYSTLGYVLYVILFNNLAVLWFNVHFDTLTIILPMSVGMIFGALVMGRFKIKMEKYVYRNIIDGVMFGVGNIFMLMAASAAGNAIAFSFAQLGVIISTIGGILFLGEKKTKKELVYVGIGSVLFVTGAVLLAIVKSKG
>NZ_LT604076.1|WP_087009870.1|773795_775340_+|zinc-ABC-transporter-substrate-binding-protein-AdcA
MKKKRIFGLAGLAAVVLAAGAGIYYTTSQHDSKGNGDLKVVTSFYPVYEFTKQVVRDEGEVSYLIPAGSEVHDFQPSTKNVADIEKADTFVYLNENMETWVPKVEKNINTKHTKVIKASKGMILLPGTEEEDHDHGGEEHYHAYDPHVWLSPKRSQKLVETIRDGLIAQHPDKKAVFTTNAEKYLKKLQALDKEYTEAFSQAKQKSFVTQHSAFAYLALDYGLTQVPISGVSAESDPSAKRIASLSKYVSEYDIKYIYFEENASSSIAKTLANEVGVKTAVLNPIESLTKDQLKKGEDYVSVMTENLKSLRLTTDVEGKDIQPEDRSNDKKTVQNGYFDDKDVKDRELSDWSGEWQSVYPFLQDGTLDQVFEYKSLLNKDKTAQEYKEYYTKGYQTDVSKIAIDGKKMTMTFTKTDGSSVTHTYRYDGYKILTYSSGKKGVRYLFTATDSQAADNPYQYVQFSDHQIDPTRSAHFHIFFGNSSQEEILKEMDNWPTYYPGKLSGFEIAQEMVSH
>NZ_LT604076.1|WP_011225860.1|775554_775953_+|hypothetical-protein
MNQYLVAIHYIQLLQAELNILNHDARLLFDLKIDPNLAKRELADLKVSLSKLSDKNLYIEGTIWYQPSLFAIIDQNLGVIDDWLKELDDFFEFSYGTTVYSVLKENENRSYDLLLGLYNRLEYVISDIKNCR
>NZ_LT604076.1|WP_087009871.1|777897_778905_-|YeiH-family-putative-sulfate-export-transporter
MTIKEFLPGISISILISLIAWYLGNLFPIIGGPVIGLFIGLLLASLLINQKRFIIGMQFTSKKVLQYAVVLLGFGLNLSQVFNVGLTSLPIILTTIATALITAYVIHKLFKLDSEIVTLVGVGSSICGGSAIAATAPVIKAKDESIATAISVIFFFNILAALLFPHLGSWLGLSNQGFAIFAGTAVNDTSSVTATASSWDSLHGTSILEQATIVKLTRTLAIIPITLGLSIWQSKKDNTKERFSLTKAIPNFILWFLLASLITTVAMSMGVPAAIFAPLKDLSKFMIIMAMTAIGYQTNLKKLITKGGSALLVGGLCWLLISVVSLLMQKLLGFW
>NZ_LT604076.1|WP_011681073.1|780771_781680_-|LysR-family-transcriptional-regulator
MRIQQLHYIIKIVETGSMNEAAKQLFITQPSLSNAVRDLEREMGIDIFIRNPKGITLTKDGVEFLSYARQVVEQTNLLEERYKSHTETRELFSVSSQHYAFVVNAFVSLLKRADMTRYELFLRETRTYEIIEDVKNFRSEIGVLFLNGYNRDVLTKMFDDNRLTYTSLFKARPHIFVSKSNPLAKHKVVSLEDLEDFPYLSYDQGIHNSFYYSEEILSQIPHKKSIVVSDRATLFNLLIGLDGYTIATGILNSNLNGDNIVSIPLDVDDEIDIVYLKHEKATLSKMGEKFLDNLVKEVTFDN
>NZ_LT604076.1|WP_087009872.1|781887_783696_+|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGVVGNTNATDILIQGLEKLEYRGYDSAGIFVAGETSSQSVKAVGRIAELTAKIEGVEGTAGIGHTRWATHGKPTEDNAHPHRSETERFVLVHNGVIENYLEIKEEYLSGHHFKGQTDTEIAVHLIGKFVEEDGLSTIESFKKALRIIRGSYAFALMDSEDASTIYVSKNKSPLLIGLGDGYNMVCSDAMAMIRETNQYMEIHDQELVIVKADSVEVQDYDGNVKERDSYTAELDLSDIGKGTYPYYMLKEIDEQPTVMRKLIQAYTDDKGQVTVDAKIIKAVQEADRIYILAAGTSYHAGFASKKMLEELTDTPVELGISSEWGYGMPLLSKKPLFVFISQSGETADSRQVLVKANELGIPSLTVTNVPGSTLSREADHTMLLHAGPEIAVASTKAYTAQIATLAFLAKAVGEANGNEKARAFDLVHELSLVAQSIESTLSEKEVIDEKVAALLSETRNAFYIGRGQDYYVAMEASLKLKEISYIQCEGFAAGELKHGTIALIEDGTPVIALLSDPVLASHTRGNIQEVVARGAKVLTIAEENVAKEGDDIVLNNVHPYLSPISMVVPTQLIAYFATLHRGLDIDKPRNLAKSVTVE

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Crispr_ID: NZ_LT604076_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LT604076_2

849603-849704

TypeIII

Consensus_repeat	Method
GATATAAACCTAATTACCTCGAGAGGGGAC	CRISPRCasFinder

1 spacers

cas2,cas1,cas6,cas10,csm2gr11,csm3gr7,csm4gr5,csm5gr7

The CRISPR arrays of NZ_LT604076_2

>merge|NZ_LT604076|2|849603-849704|CRISPRCasFinder
GATATAAACCTAATTACCTCGAGAGGGGACGGAAACGCTTTCTAGCTCGCTATAATTACCCATTCCTAGAAAGATATAAACCTAATTACCTCGAGAGGGGAC

>NZ_LT604076|2|2|849603-849704|CRISPRCasFinder
GATATAAACCTAATTACCTCGAGAGGGGAC	GGAAACGCTTTCTAGCTCGCTATAATTACCCATTCCTAGAAA
GATATAAACCTAATTACCTCGAGAGGGGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LT604076.1\|WP_087009902.1\|843260_844436_+\|IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NZ_LT604076.1\|WP_087009905.1\|847082_848030_+\|dihydroorotate-dehydrogenase	unknown	unknown	gnl\|CDD\|235982
NZ_LT604076.1\|WP_065973181.1\|853232_853895_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|187815
NZ_LT604076.1\|WP_087009908.1\|850554_852837_+\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	cas10	cd09680_cas10_CAS-III	gnl\|CDD\|187811
NZ_LT604076.1\|WP_002952956.1\|846260_847064_+\|dihydroorotate-dehydrogenase-electron-transfer-subunit	unknown	unknown	gnl\|CDD\|234601
NZ_LT604076.1\|WP_087009896.1\|837866_838502_-\|HAD-hydrolase-like-protein	unknown	unknown	gnl\|CDD\|319798
NZ_LT604076.1\|WP_087009904.1\|845470_846019_+\|DJ-1/PfpI-family-protein	unknown	unknown	gnl\|CDD\|153229
NZ_LT604076.1\|WP_002946679.1\|857399_858095_+\|orotidine-5'-phosphate-decarboxylase	unknown	unknown	gnl\|CDD\|234695
NZ_LT604076.1\|WP_087009906.1\|848168_849173_+\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187766
NZ_LT604076.1\|WP_014621548.1\|852840_853233_+\|type-III-A-CRISPR-associated-protein-Csm2	csm2gr11	cd09647_csm2gr11_CAS-III-A	gnl\|CDD\|367635
NZ_LT604076.1\|WP_087009907.1\|849842_850574_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NZ_LT604076.1\|WP_087009894.1\|836242_836614_+\|hypothetical-protein	unknown	unknown	unknown
NZ_LT604076.1\|WP_087009901.1\|841290_842949_-\|fibronectin/fibrinogen-binding-protein	unknown	unknown	gnl\|CDD\|336217
NZ_LT604076.1\|WP_087009909.1\|854798_855872_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	csm5gr7	cd09662_csm5gr7_CAS-III-A	gnl\|CDD\|224251
NZ_LT604076.1\|WP_087009911.1\|859509_860961_-\|peptide-MFS-transporter	unknown	unknown	gnl\|CDD\|225646
NZ_LT604076.1\|WP_087009895.1\|837040_837805_+\|nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|350158
NZ_LT604076.1\|WP_014608281.1\|849172_849502_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_LT604076.1\|WP_087009910.1\|858183_858813_+\|orotate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234771
NZ_LT604076.1\|WP_011227195.1\|866937_868308_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	unknown	unknown	gnl\|CDD\|235392
NZ_LT604076.1\|WP_014608283.1\|853896_854796_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm4	csm4gr5	COG1567_csm4gr5_CAS-III-A	gnl\|CDD\|380071

Protein	Function_ID	Function_description	E-value
NZ_LT604076.1\|WP_087009902.1\|843260_844436_+\|IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	3.14628e-180
NZ_LT604076.1\|WP_087009905.1\|847082_848030_+\|dihydroorotate-dehydrogenase	gnl\|CDD\|235982	PRK07259, PRK07259, dihydroorotate dehydrogenase.	2.69692e-170
NZ_LT604076.1\|WP_002946679.1\|857399_858095_+\|orotidine-5'-phosphate-decarboxylase	gnl\|CDD\|234695	PRK00230, PRK00230, orotidine-5'-phosphate decarboxylase.	6.17386e-139
NZ_LT604076.1\|WP_087009908.1\|850554_852837_+\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	gnl\|CDD\|187811	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; signature gene for type III; also known as Csm1 family.	0
NZ_LT604076.1\|WP_002952956.1\|846260_847064_+\|dihydroorotate-dehydrogenase-electron-transfer-subunit	gnl\|CDD\|234601	PRK00054, PRK00054, dihydroorotate dehydrogenase electron transfer subunit; Reviewed.	7.21815e-125
NZ_LT604076.1\|WP_087009896.1\|837866_838502_-\|HAD-hydrolase-like-protein	gnl\|CDD\|319798	cd04302, HAD_5NT, haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to the Pseudomonas aeruginosa PA0065. 5'-nucleotidases dephosphorylate nucleoside 5'-monophosphates to nucleosides and inorganic phosphate. Purified Pseudomonas aeruginosa PA0065 displayed high activity toward 5'-UMP and 5'-IMP, significant activity against 5'-XMP and 5'-TMP, and low activity against 5'-CMP. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.59737e-82
NZ_LT604076.1\|WP_087009904.1\|845470_846019_+\|DJ-1/PfpI-family-protein	gnl\|CDD\|153229	cd03135, GATase1_DJ-1, Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1. Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1. DJ-1 is involved in multiple physiological processes including cancer, Parkinson's disease and male fertility. It is unclear how DJ-1 functions in these. DJ-1 has been shown to possess chaperone activity. DJ-1 is preferentially expressed in the testis and moderately in other tissues; it is induced together with genes involved in oxidative stress response. The Drosophila homologue (DJ-1A) plays an essential role in oxidative stress response and neuronal maintenance. Inhibition of DJ-1A function through RNAi, results in the cellular accumulation of reactive oxygen species, organismal hypersensitivity to oxidative stress, and dysfunction and degeneration of dopaminergic and photoreceptor neurons. DJ-1 has lacks enzymatic activity and the catalytic triad of typical GATase1 domains, however it does contain the highly conserved cysteine located at the nucelophile elbow region typical of these domains. This cysteine been proposed to be a site of regulation of DJ-1 activity by oxidation. DJ-1 is a dimeric enzyme.	4.41337e-71
NZ_LT604076.1\|WP_087009906.1\|848168_849173_+\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187766	cd09634, Cas1_I-II-III, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	5.72974e-90
NZ_LT604076.1\|WP_014621548.1\|852840_853233_+\|type-III-A-CRISPR-associated-protein-Csm2	gnl\|CDD\|367635	pfam03750, Csm2_III-A, Csm2 Type III-A. Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-associated) proteins. This entry represents Csm2 Type III-A, a family of Cas proteins also known as TM1810/Csm2.	1.14708e-20
NZ_LT604076.1\|WP_087009907.1\|849842_850574_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	4.53685e-22
NZ_LT604076.1\|WP_065973181.1\|853232_853895_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	gnl\|CDD\|187815	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	9.64862e-85
NZ_LT604076.1\|WP_087009901.1\|841290_842949_-\|fibronectin/fibrinogen-binding-protein	gnl\|CDD\|336217	pfam05833, FbpA, Fibronectin-binding protein A N-terminus (FbpA). This family consists of the N-terminal region of the prokaryotic fibronectin-binding protein. Fibronectin binding is considered to be an important virulence factor in streptococcal infections. Fibronectin is a dimeric glycoprotein that is present in a soluble form in plasma and extracellular fluids; it is also present in a fibrillar form on cell surfaces. Both the soluble and cellular forms of fibronectin may be incorporated into the extracellular tissue matrix. While fibronectin has critical roles in eukaryotic cellular processes, such as adhesion, migration and differentiation, it is also a substrate for the attachment of bacteria. The binding of pathogenic Streptococcus pyogenes and Staphylococcus aureus to epithelial cells via fibronectin facilitates their internalisation and systemic spread within the host.	0
NZ_LT604076.1\|WP_087009909.1\|854798_855872_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	gnl\|CDD\|224251	COG1332, COG1332, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	5.63299e-22
NZ_LT604076.1\|WP_087009911.1\|859509_860961_-\|peptide-MFS-transporter	gnl\|CDD\|225646	COG3104, PTR2, Dipeptide/tripeptide permease [Amino acid transport and metabolism].	3.40697e-137
NZ_LT604076.1\|WP_087009895.1\|837040_837805_+\|nucleoside-phosphorylase	gnl\|CDD\|350158	cd09007, NP-I_spr0068, uncharacterized subfamily of the nucleoside phosphorylase-I family. This subfamily is composed of uncharacterized members including Streptococcus pneumoniae hypothetical protein spr0068. The nucleoside phosphorylase-I (NP-I) family members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases such as purine nucleoside phosphorylase (PNP, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases such as AMP nucleosidase (AMN, EC 3.2.2.4) and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). Members of the NP-I family display different physiologically relevant quaternary structures: hexameric (trimer-of-dimers arrangement of Shewanella oneidensis MR-1 UP); homotrimeric (human PNP and Escherichia coli PNPII or XapA); hexameric (with some evidence for co-existence of a trimeric form) such as E. coli PNPI (DeoD); or homodimeric such as human and Trypanosoma brucei UP. The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	5.14384e-94
NZ_LT604076.1\|WP_014608281.1\|849172_849502_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.55023e-20
NZ_LT604076.1\|WP_087009910.1\|858183_858813_+\|orotate-phosphoribosyltransferase	gnl\|CDD\|234771	PRK00455, pyrE, orotate phosphoribosyltransferase; Validated.	3.64195e-78
NZ_LT604076.1\|WP_011227195.1\|866937_868308_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	gnl\|CDD\|235392	PRK05291, trmE, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE.	0
NZ_LT604076.1\|WP_014608283.1\|853896_854796_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm4	gnl\|CDD\|380071	pfam17953, Csm4_C, CRISPR Csm4 C-terminal domain. Clustered, regularly interspaced, short palindromic repeat (CRISPR) loci play a pivotal role in the prokaryotic host defense system against invading genetic materials. The CRISPR loci are transcribed to produce CRISPR RNAs (crRNAs), which form interference complexes with CRISPR-associated (Cas) proteins to target the invading nucleic acid for degradation. The interference complex of the type III-A CRISPR-Cas system is composed of five Cas proteins (Csm1-Csm5) and a crRNA, and targets invading DNA. This entry represents the C-terminal domain found in Csm4. Csm4 structurally resembles Cmr3, a component of the type III-B CRISPR-Cas interference complex. Studies indicate that Csm3-Csm4 complex binds single-stranded RNA in a non-sequence-specific manner. Structural analysis show, Csm3 and Csm4 have one and two ferredoxin-like folds (also known as an RRM-like fold), respectively. The long beta-hairpin inserted into the C-terminal ferredoxin-like fold of Csm4, is well-conserved in the Cmr3 structure. The corresponding beta-hairpin of Cmr3 binds the D1 domain of Cmr2, as observed in the Cmr2-Cmr3 complex structure. Furthermore, it is suggested that the hairpin of Csm4 is responsible for the interaction with Csm1 (ortholog of Cmr2).	7.57749e-38

>NZ_LT604076.1|WP_014608281.1|849172_849502_+|CRISPR-associated-endonuclease-Cas2
MGLYFNLSEEEREFAKQKTMFCLIIYDIRSNKRRLKLSKLLEGYGVRVQKSCFEVDLSRNDYQSLLKDIEGFYKADEEDSIIVYVTTKEEVTSFSPYHSAEKLDDILFF
>NZ_LT604076.1|WP_087009906.1|848168_849173_+|CRISPR-associated-endonuclease-Cas1
MSDLYIQRSNYYLSSSEQRIIIKNDNKEIVKEVSISLVDNVLLFGNAQLTTQLIKALSKNKVNVYYFSNVGQFISSIETHRQDEFQKQELQAKAYFEEDFRLEVARSIATTKVRHQIALLREFDTDGLLDTSDYSRFEDSVNDIQKAYSITEIMGYEGRLAKSYFYYLNLLVPDDLHFNGRSRRPAEDCFNSALNFGYSILYSCFMGLIKKNGLSLGFGVIHKHHQHHATLASDLIEEWRPIIVDNTLMELIRNGKLLLSHFENKDQDFILTDEGREIFARALRSRILEVHQYIELDKKRYSFLYTADRQIKSLIRAFRELDLSLYETSYTGGH
>NZ_LT604076.1|WP_087009905.1|847082_848030_+|dihydroorotate-dehydrogenase
MKSENRLAISLPGLDLKNPIIPASGCFGFGQEYSKYYDLDKLGSIMIKATTANPRFGNPTPRVAETPSGMLNAIGLQNPGVDAVLSEKLPWLQEHYPELPIIANVAGFSNEEYAEVSHKISKASNVKAIELNISCPNVDHGNNGLLIGQVPELAYAAVKASVSHSDVPVYVKLTPSVADITSVAKAVEDAGATGFTMINTLVGTRYDLATRKPIIANGQGGMSGPAVFPVALKLIRQVALASDLPIIGMGGVDSAEAAIEMFISGASAIGVGTANFADPYACPKIIDRLPEVMDKYGITTLEDLREEVRTDLLGK
>NZ_LT604076.1|WP_002952956.1|846260_847064_+|dihydroorotate-dehydrogenase-electron-transfer-subunit
MTFCSIERVVMILIEDLTVVSQREIAPRIFEMVLKGEMVADMQLGQFVHLKVPDPSKLLRRPISISEIDYNKKEATIVYRVEREGTAILSKMVAGQTIDTMGPQGNGFDISIIEAGQKALLVGGGIGVPPLVETAKQLKAKGVEVVSVIGFANKNAVILEDKLRACGDVYVTTDDGSYGIKGYVSTVIDNFDWTPDAVYSCGAPGMLKYVDSKFENHPHAYVSMEARMACGMGACYACVVHVKGETDAKNLRVCEEGPVFPTGKVIV
>NZ_LT604076.1|WP_087009904.1|845470_846019_+|DJ-1/PfpI-family-protein
MTKVAVVFAEGFEEIEALSPVDVFRRAGFDCSMLGLESASVIGSHGIQVTMDGVFDGNLDEYDLVVLPGGMPGSTKLRDHQALIASLQEVDKAGKYVAAICAAPIVLERAGLLEGRKFTCFPGVEEQIASGEHQTDLVVVDGNIVTSRGAGTALAFAYALVDLLGGDGQQLAHTMVYDRLFQ
>NZ_LT604076.1|WP_087009902.1|843260_844436_+|IS256-family-transposase
MTQFTKELLNFLAQKQDSDEFFRTSLETAMNDLLQAELSAFLGYEPYDKLGYNSGNSRNGSYARKFETKYGTVQLSIPRDRNGNFSPALLPAYGRRDDHLEEMVIKLYQTGVTTREISDIIERMYGHHYSPATISNISKATQENVATFHERSLEANYSVLFLDGTYLPLRRGTVSKECIHIALGITPEGQKAVLGYEIAPNENNASWSTLLDKLQNQGIQQVSLVVTDGFKGLEEIINQAYPLAKQQRCLIHISRNLASKVKRADRAVILEQFKTIYRAENLEMAVQILENFIAEWKPKYRKVMESLENTDNLLTFYQFPYQIWHSIYSTNLIESLNKEIKRQTKKKVLFPNEEALERYLVTLFEDYNFKQNQRIHKGFGQCADTLESLFD
>NZ_LT604076.1|WP_087009901.1|841290_842949_-|fibronectin/fibrinogen-binding-protein
MSFDGFFLHHMTAELREQVLYGRIQKVNQPFERELVLTIRNNRQNYKLLLSAHPVFGRIQTTKAELPNPQNPNTYTMIMRKYLQGAIIEDIQQLENDRVLEISVSNKNEIGDSVKVTLVMEIMGKHSNIILIDKNENKIIESIKHVGFSQNSYRTILPGSTYIAPPKTDARNPFDISDENLFELLQTEDLSAKNLQKLFQGLGRDTANELSALLETDKLKNFRDFFNREVEPNLTTKAFSAVRFSDSQDQPEFETLSELLDYYYLDKAARDRVAQQASDLIHRVQNELEKNKKKLVKQEKELAATENAEEFRQKGELLTTFLSMVPNDKDSVELDNYYTGEKITIPLNVALTPNQNAQRYFKKYQKLKEAVKHLTGLIEETKQTINYLESVEFSLSQANMDEIEDIREELVQAGFMRRRSTDKRQKRKKPERYLASDGKTIIMVGRNNLQNEELTFKMAKKGELWFHAKDIPGSHVVIKDNLNPTDEVKTDAAELAAYYSKARLSNLVQVDMIDVKKLNKPTAGKPGFVTYTGQKTLRVTPTEEKIDSMRMK
>NZ_LT604076.1|WP_087009896.1|837866_838502_-|HAD-hydrolase-like-protein
MTFTHIFFDLDGTLIDSSEGIHNGFVQTFERLGLPVPSDQKIRTFMGPPLEVTFKEEISEEGAAQAVKIYRDYYETKGQFEAHLYDGIKEVLEKLSHDPNKKIYITTSKNEPTALEMCEYLGITEFFDGIYGATPTAFHKADVLQCAITENNANKDSSVIVGDTKFDLIGGKTVGIKTIAVTWGFGTNETLLAENPDFVAETTQELWDILK
>NZ_LT604076.1|WP_087009895.1|837040_837805_+|nucleoside-phosphorylase
MIHKHEIPILEFDDSPQAVIMPTHEDLDLDLPARCIYAFLEEEIERYANAVEADKVGEFVSATKTYPIFVMTYNGEEICLAQAPVGSAAAAQFLDWLIGYGVKQIISTGTCGVLVNMKENVFLIPTRALRDEGASYHYVAPSRYIDMNKQALEAIEKTLKQKKIPYEEVMTWSTDGFYRETPDKVSYRIEEGCSVVEMECSALAAVTQLRGAIWGLLLFTADSLADIDNYDQRDWGSEAFDKALELCLDIIVQM
>NZ_LT604076.1|WP_087009894.1|836242_836614_+|hypothetical-protein
MKKKSVQKVEKKIKKQLKKQKLGLPISSFSFLSNFSHDEKEKNLDTLSSDNLKEGKKDFAGYYQISYQTLIDKELIEMVIYIDEKITVKSQDMKDAAKKLDASDLPNGEYNFFYSNTKDENQD
>NZ_LT604076.1|WP_087009907.1|849842_850574_+|CRISPR-associated-endoribonuclease-Cas6
MKKLVFTFKRIDHPAQDLAVKFHGFLMEQLDSDYVDYLHQQQTNPYATKVIQGKENTQWVVHLLTDDLEDKVFMTLLQIKEVSLNDLPKLSVEKVEIQELGADKLLEIFNSEENQTYFSIIFETPTGFKSQGSYVIFPSMRLIFQSLMQKYGRLVENQPEIEEDTLDYLSEHSTITNYRLETSYFRVHRQRIPAFRGKLTFKVQGAKTLKAYVKMLLTFGEYSGLGMKTSLGMGGIKLEERKD
>NZ_LT604076.1|WP_087009908.1|850554_852837_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1
MKKEKIDLFYGALLHDIGKVIQRATGERKKHALVGADWFDEIADNQVISDQIRYHMANYQSDKLGNDHLAYITYIADNIASGVDRRQSNEESDEDTSAKIWDTYTNQADIFNVFGAQTDKRYFKPTVLNLKSKPNFASATYEPFSKGDYAAIATRIKNELAEFEFNQAQIDSLLNLFEATLSFVPSSTNTKEIADISLAEHSRLTAAFALAIYDYLEDKGRHNYKEDLFTKASAFYEEEAFLLASFDLSGIQDFIYNIDIATNGAAKQLKARSLYLDFMSEYIADSLLDKLGLNRANLLYVGGGHAYFVLANTEKTVETLVQFEKDFNQFLLANFQTRLYVAFGWGSFAAKDIMSELNSPESYRQVYQKASRMISEKKISRYDYQTLMLLNRGGKSSERECEICHSVENLVAYHDQKVCDICRGLYQFSKEIAHDHFIITENEGLPIGPNACLKGVAFEKLSQEAFSRVYVKNDYKAGTVKVTHVFVGDYQCDEIYNYAALSKNENGLGIKRLAVVRLDVDDLGAAFMAGFSQQGNGQYSTLSRSATFSRSMSLFFKVYINQFASDKKLSIIYAGGDDVFAIGSWQDIIAFTVELRENFIKWTNGKLTLSAGIGLFADKTPISLMAHQTGELEEAAKGNEKDSISLFSSDYTFKFDRFITNVYDDKLEQIRYFFNHQDERGKNFIYKLIELLRNYESEEKMNVARLAYYLTRLEELTDKDERDKFKQFKKLFFKWYTNNESDRKEAELALLLYVYEIRKD
>NZ_LT604076.1|WP_014621548.1|852840_853233_+|type-III-A-CRISPR-associated-protein-Csm2
MAILTDENYVDKAERAISLLEKDNKGNYLLTTSQIRKLLSLCSSLYDRSKERKFDELINDVSYLRVQFVYQSGRNSVRVNRQTFFPVKDLVEKGQILEALKEIKDRETLQRFCRYMEALVAYFKFYGGKD
>NZ_LT604076.1|WP_065973181.1|853232_853895_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3
MTFAKIKFSAQIRLETGLHIGGSDAFAAIGAIDSPVIKDPITNLPIIPGSSLKGKMRTLLAKVYNEKVSEKPSDDSDILSRLFGNSKDKRFKMGRLIFRDAFLSNADELDSLGVSSYTEVKFENTIDRITAEANPRQIERVIRNSTFDFELIYEITDENENQVEEDFKVIRDGLKLLELDYLGGSGSRGYGKVAFENLKATTVFGNYDVKTLNELLTAEV
>NZ_LT604076.1|WP_014608283.1|853896_854796_+|type-III-A-CRISPR-associated-RAMP-protein-Csm4
MTYKLYIMTFQNAHFGSGTLDSSKLTFSADRIFSALVLEALKMGKLDAFLAEANQDKFTLTDAFPFQFGPFLPKPIGYPKHDQIDQSVDVKEVRRQAKLSKKLQFLALENVDDYLNGELFENEEHAVIDTVTKNQPHKDDNLYQVATTRFSNDTSLYVIANESDLLNELMSSLQYSGLGGKRSSGFGRFELDIQNIPLELSDRLTKNHSDKVMSLTTALPVDADLEEAMEDGHYLLTKSSGFAFSHATNENYRKQDLYKFASGSTFSKTFEGQIVDVRPLDFPHAVLNYAKPLFFKLEV
>NZ_LT604076.1|WP_087009909.1|854798_855872_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5
MKNDYRTFKLSLLTLAPIHIGNGEKYTSREFIYENKKFYFPDMGKFYNKMVEKRLAEKFEAFLIQTRPNARNNRLISFLNDNRIAERSFGGYSISETGLESDKNPDSAGAINEVNKFIRDAFGNPYIPGSSLKGAIRTILMNTTPKWNNENAVNDFGRFPKENKNLIPWGPKKGKEYDDLFNAIRVSDSKPFDNKSLILVQKWDYSAKTNKAKPLPLYRESISPLTKIEFEITTTTDEAGRLIEELGKRAQAFYKDYKAFFLSEFPDDKIQANLQYPIYLGAGSGAWTKTLFKQADGILQRRYSRMKTKMIKKGVLKLTKAPLKTVKIPSGNHSLVKNHESFYEMGKANFMIKEIDK
>NZ_LT604076.1|WP_002946679.1|857399_858095_+|orotidine-5'-phosphate-decarboxylase
MRENRPVIALDFPTLEDVKAFLAKFPADEKLYVKIGMELYYAAGPEIVRYVKELGHSVFLDLKLHDIPNTVKSAMRVLSNLGVDMTNVHAAGGVEMMKAAREGLGDGPILIAVTQLTSTSEEQMRDFQNIQTTLQESVVHYAQKTAEAGLDGVVCSAHEVAKIKEATNQDFVCLTPGIRPAGAAVGDQKRVMTPADAHQIGSDYIVVGRPITQAEDPVAAYHDIKAQWNDQ
>NZ_LT604076.1|WP_087009910.1|858183_858813_+|orotate-phosphoribosyltransferase
MTLASQIASDLLDIKAVYLKPEEPFTWASGIKSPIYTDNRITLSYPETRTLIENGFVKKIKEEFPEVEVIAGTATAGIPHGAIIADKMNLPFAYIRSKPKDHGAGNQIEGRVVKGEKMVVVEDLISTGGSVLDAVAAAEREGADVIGVVAIFTYELPKAEKNFAKAGVKLVTLSNYTELIKVAKVKGYITADGLRLLKKFKENQETWQD
>NZ_LT604076.1|WP_087009911.1|859509_860961_-|peptide-MFS-transporter
MEDKGKTFFGQPLGLLTLFMTEMWERFSYYGMRAILLYYMWFLISTGDLHITRATAASIMAIYASMVYLSGTIGGFVADRIIGARPAVFWGGVLIMLGHIVLALPFGASALFGSIILIIIGTGFLKPNVSTLVGTLYDEHDRRRDAGFSIFVFGINLGAFIAPLIVGAAQEAAGYHVAFSLAAIGMFIGLLVYYFGGKKTLDPRYLRPTDPLAPEEVKPLLVKVSLAVAGFIAIIVVMNLVGWNSLPAYINLLTIVAIAIPVFYFAWMISSVKVTSTEHLRVVSYIPLFIAAVLFWAIEEQGSVVLATFAAERVDSSWFPVSWFQSLNPLFIMLYTPFFAWLWTAWKKNQPSSPTKFAVGLMFAGLSFLLMAIPGALYGTSGKVSPLWLVGSWALVILGEMLISPVGLSVTTKLAPKSFNSQMMSMWFLSSSVGSALNAQLVTLYNAKSEVAYFSYFGLGSVVLGIVLVFLSKRIQGLMQGVE
>NZ_LT604076.1|WP_011227195.1|866937_868308_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE
MSITKEFDTITAISTPLGEGAIGIVRLSGTDAIAIANKVFKGKNLETVDSHTINYGHIVENNEIIDEVMVSVMRAPKTFTREDVVEINTHGGVAVTNEILQLLIRSGARMAEPGEFTKRAFLNGRIDLTQAEAVMDLIRAKTDKAMTVAVSQLDGSLKNLINNTRQEILNTLAQVEVNIDYPEYDDVEEVTTNLVREKTQEFQALLENLLATAKRGKILREGLSTAIIGRPNVGKSSLLNNLLREEKAIVTDIEGTTRDVIEEYVNIKGVPLKLIDTAGIRDTDDVVEKIGVERSKKALEEADLVLLVLNSSEPLTDQDRTLLDISQNSNRIILLNKTDLPQAIQTEELPEDLIPISVLKNENIDKIEDRINQLFFDNAGLVEKDATYLSNARHISLIEKALESLEAVNQGLELGMPVDLLQVDMTRTWEILGEITGDAAPDELITQLFSQFCLGK

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Crispr_ID: NZ_LT604076_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LT604076_3

1486288-1486379

Unclear

Consensus_repeat	Method
CTTTTCTTTACGATATCAATTTTAACATCTTT	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_LT604076_3

>merge|NZ_LT604076|3|1486288-1486379|CRISPRCasFinder
CTTTTCTTTACGATATCAATTTTAACATCTTTAACAAAATTTGTTTTTGAAAACGCTTCACTTTTCTTTACGATATTAATTTTAACATCTTT

>NZ_LT604076|3|3|1486288-1486379|CRISPRCasFinder
CTTTTCTTTACGATATCAATTTTAACATCTTT	AACAAAATTTGTTTTTGAAAACGCTTCA
CTTTTCTTTACGATATTAATTTTAACATCTTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LT604076.1\|WP_002951893.1\|1490557_1491013_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|131622
NZ_LT604076.1\|WP_002947698.1\|1476627_1476987_-\|holo-ACP-synthase	unknown	unknown	gnl\|CDD\|234610
NZ_LT604076.1\|WP_087010162.1\|1473356_1475375_-\|ATP-dependent-DNA-helicase-RecG	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|236794
NZ_LT604076.1\|WP_087010172.1\|1493315_1493705_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213235
NZ_LT604076.1\|WP_002947702.1\|1481906_1482164_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LT604076.1\|WP_087010168.1\|1484341_1486243_-\|PTS-sugar-transporter-subunit-IIBCA	unknown	unknown	gnl\|CDD\|131051
NZ_LT604076.1\|WP_087010167.1\|1483263_1484157_-\|ROK-family-protein	unknown	unknown	gnl\|CDD\|366120
NZ_LT604076.1\|WP_011226532.1\|1478119_1479151_-\|3-deoxy-7-phosphoheptulonate-synthase	unknown	unknown	gnl\|CDD\|223794
NZ_LT604076.1\|WP_087010166.1\|1482250_1483198_-\|mannose-6-phosphate-isomerase,-class-I	unknown	unknown	gnl\|CDD\|224399
NZ_LT604076.1\|WP_002951890.1\|1488997_1489432_-\|transcription-antitermination-factor-NusB	unknown	unknown	gnl\|CDD\|234686
NZ_LT604076.1\|WP_002951896.1\|1492281_1492710_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LT604076.1\|WP_087010165.1\|1479174_1481724_-\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NZ_LT604076.1\|WP_002946571.1\|1493892_1494084_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LT604076.1\|WP_087010170.1\|1487942_1488908_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380514
NZ_LT604076.1\|WP_087010171.1\|1491031_1492093_-\|aminopeptidase-P-family-protein	unknown	unknown	gnl\|CDD\|223085
NZ_LT604076.1\|WP_087010164.1\|1476990_1478022_-\|3-deoxy-7-phosphoheptulonate-synthase	unknown	unknown	gnl\|CDD\|236435
NZ_LT604076.1\|WP_087010163.1\|1475503_1476607_-\|alanine-racemase	unknown	unknown	gnl\|CDD\|234600
NZ_LT604076.1\|WP_011227545.1\|1489884_1490445_-\|elongation-factor-P	unknown	unknown	gnl\|CDD\|234788
NZ_LT604076.1\|WP_002951891.1\|1489424_1489814_-\|Asp23/Gls24-family-envelope-stress-response-protein	unknown	unknown	gnl\|CDD\|377129
NZ_LT604076.1\|WP_087010169.1\|1486491_1487934_+\|sucrose-6-phosphate-hydrolase	unknown	unknown	gnl\|CDD\|273554

Protein	Function_ID	Function_description	E-value
NZ_LT604076.1\|WP_002951893.1\|1490557_1491013_-\|hypothetical-protein	gnl\|CDD\|131622	TIGR02571, putative_dCMP_deaminase, ComE operon protein 2. This protein is found in the ComE operon for "late competence" as characterized in B. subtilis. Proteins in this family contain homology to a cytidine/deoxycytidine deaminase domain family (pfam00383), and may carry out this activity.	3.00916e-65
NZ_LT604076.1\|WP_002947698.1\|1476627_1476987_-\|holo-ACP-synthase	gnl\|CDD\|234610	PRK00070, acpS, 4'-phosphopantetheinyl transferase; Provisional.	3.31699e-52
NZ_LT604076.1\|WP_087010162.1\|1473356_1475375_-\|ATP-dependent-DNA-helicase-RecG	gnl\|CDD\|236794	PRK10917, PRK10917, ATP-dependent DNA helicase RecG; Provisional.	0
NZ_LT604076.1\|WP_087010172.1\|1493315_1493705_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	9.16177e-39
NZ_LT604076.1\|WP_087010170.1\|1487942_1488908_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380514	cd06291, PBP1_Qymf-like, ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs. This group includes the ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus metalliredigens (strain Qymf) and its close homologs. Qymf is a strict anaerobe that could be grown in the presence of borax and its cells are straight rods that produce endospores. This group is a member of the LacI-GalR family repressors that are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	3.21338e-103
NZ_LT604076.1\|WP_087010168.1\|1484341_1486243_-\|PTS-sugar-transporter-subunit-IIBCA	gnl\|CDD\|131051	TIGR01996, Includes:_Phosphotransferase_enzyme_IIB_component, PTS system, sucrose-specific IIBC component. This model represents the fused enzyme II B and C components of the sucrose-specific PTS sugar transporter system. Sucrose is converted to sucrose-6-phosphate in the process of translocation into the cell. Some of these transporters lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). The exceptions to this rule are Staphylococci, Streptococci, Lactococci, Lactobacilli, etc. which contain their own A domain as a C-terminal fusion. This family is closely related to the trehalose transporting PTS IIBC enzymes and the B and C domains of each are described by subfamily-domain level TIGRFAMs models (TIGR00826 and TIGR00852, respectively).	0
NZ_LT604076.1\|WP_087010167.1\|1483263_1484157_-\|ROK-family-protein	gnl\|CDD\|366120	pfam00480, ROK, ROK family.	1.58285e-89
NZ_LT604076.1\|WP_011226532.1\|1478119_1479151_-\|3-deoxy-7-phosphoheptulonate-synthase	gnl\|CDD\|223794	COG0722, AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism].	1.53222e-173
NZ_LT604076.1\|WP_087010166.1\|1482250_1483198_-\|mannose-6-phosphate-isomerase,-class-I	gnl\|CDD\|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	2.38419e-132
NZ_LT604076.1\|WP_002951890.1\|1488997_1489432_-\|transcription-antitermination-factor-NusB	gnl\|CDD\|234686	PRK00202, nusB, transcription antitermination factor NusB.	2.86566e-48
NZ_LT604076.1\|WP_087010165.1\|1479174_1481724_-\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NZ_LT604076.1\|WP_087010171.1\|1491031_1492093_-\|aminopeptidase-P-family-protein	gnl\|CDD\|223085	COG0006, PepP, Xaa-Pro aminopeptidase [Amino acid transport and metabolism].	8.75926e-115
NZ_LT604076.1\|WP_087010164.1\|1476990_1478022_-\|3-deoxy-7-phosphoheptulonate-synthase	gnl\|CDD\|236435	PRK09261, PRK09261, phospho-2-dehydro-3-deoxyheptonate aldolase; Validated.	3.17109e-165
NZ_LT604076.1\|WP_087010163.1\|1475503_1476607_-\|alanine-racemase	gnl\|CDD\|234600	PRK00053, alr, alanine racemase; Reviewed.	6.23262e-165
NZ_LT604076.1\|WP_011227545.1\|1489884_1490445_-\|elongation-factor-P	gnl\|CDD\|234788	PRK00529, PRK00529, elongation factor P; Validated.	6.42716e-90
NZ_LT604076.1\|WP_002951891.1\|1489424_1489814_-\|Asp23/Gls24-family-envelope-stress-response-protein	gnl\|CDD\|377129	pfam03780, Asp23, Asp23 family, cell envelope-related function. The alkaline shock protein Asp23 was identified as an alkaline shock protein that was expressed in a sigmaB-dependent manner in Staphylococcus aureus. Following an alkaline shock Asp23 accumulates in the soluble protein fraction of the S. aureus cell. Asp23 is one of the most abundant proteins in the cytosolic protein fraction of stationary S. aureus cells, with a copy-number of >25000 per cell. A second Asp23-family protein, AmaP, which is encoded within the asp23-operon, is required to localize Asp23 to the cell membrane. The overall function for the family is thus a cell envelope-related one in Gram-positive bacteria.	3.33947e-31
NZ_LT604076.1\|WP_087010169.1\|1486491_1487934_+\|sucrose-6-phosphate-hydrolase	gnl\|CDD\|273554	TIGR01322, Sucrose-6-phosphate_hydrolase, sucrose-6-phosphate hydrolase. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0

>NZ_LT604076.1|WP_087010168.1|1484341_1486243_-|PTS-sugar-transporter-subunit-IIBCA
MDYKQIAKEVIEALGGRENVNSVAHCATRLRVMVKDENKINKEKAENIEKVQGAFFNSGQYQMIFGTGTVNKIYDEVVAQGLPTASKDEQKAEAAKQGNWFQRAIRSFGDVFVPLLPAIVATGLFMGIRGAINNDTVLALFGTTSKAFAATDFYTYTVVLTDTAFAFFPALICWSAFNVFGGSPLLGLVLGLMMVNNALPNAWDVASGAAKPIYFFDFIPVVGYQNSVLPAFFVGLIGAKFEQWVRKWVPDILDLLLRPLVVFAVMSALALFIIGPVFHTVESYVLAGTEWILALPFGLAGLVLGGIHQIIVVTGVHHVFNLLEANLISNTGKDPLNAIITAAMTAQAGATLAVGVKTKDSKLKALAFPASLSAVLGITEPAIFGVNLRFGKPFIMGLIAGAAGGWLASILNLAGTGFGVTIVPGTLLYLNGQVLKYVIMVLVTLALGFALTWIFGYKEEEVEAQTEVVAEDIASAGSAPVALQAETIAAPLKGEVVALENVNDPVFSSGAMGKGAAIKPSGNRVVAPFDGEVQIAFPTGHAYGLKSDKGAEVLIHIGIDTVSLDGKGFDAKVQANQRVKKGDVLATFDSSVITEAGLDDTTMVIVTNTADYEDVSLVATGSVAEGDDFIAVK
>NZ_LT604076.1|WP_087010167.1|1483263_1484157_-|ROK-family-protein
MAKLYGSLEAGGTKFVCAVGDEKFQVIEKTQFPTTTPYETIDCTIEFFKRYEDQLEGIAIGSFGPIDVDPNSETYGFVTSTPKPHWSNIDLLGLIAKEFNVPFYFTTDVNSSAYGETLARKGVKSLVYYTIGTGIGAGAIQNGEFIGGLGHTEVGHVYVPLHPNDVANEFNGTCPFHRGCLEGLAAGPSLEARTGIRSELIEQNSEVWDVQSYYIAQAAVQATVLYRPEVIVFGGGVMGQEHMLRRVREKFTALLNGYLPVPDVTEYIVTPAVSGNGSATLGNFALAKDVADKYSRK
>NZ_LT604076.1|WP_087010166.1|1482250_1483198_-|mannose-6-phosphate-isomerase,-class-I
MEPLFLDSPMHEKIWGGNRLKTEFGYDIPSEHTGEYWAISAHPNGVSYVKNGKYSGFHLAELYKDKPELFGHPKASVFPLLTKILDANDWLSVQVHPGDAYGMEHEGELGKTECWYIIDAEEGAEIIYGHKAQTKEELATLIEAGDWDGLLSKMPVKKGDFFFVPSGTMHAIGPGILILETQQSSDTTYRVYDFDRRDDQGNQRELHIQQSLDVLNLGEPQNSVPSTVKTMQLEMTCLTSNAFFTVYKWKFSGLVDFKQSAPYLLCSVLSGNGTLTVDSRIYCLKKGDHFLLPNNVTDWEIDGQLEMIVSHPNEA
>NZ_LT604076.1|WP_002947702.1|1481906_1482164_-|hypothetical-protein
MKDYGDHIYGLQRAISGMCGEKTASPSIKFYWENGVLEYEFYVDFEASPMIMKDYSSDRAFFEQAFENLLHDFEDFLENQEIIEG
>NZ_LT604076.1|WP_087010165.1|1479174_1481724_-|preprotein-translocase-subunit-SecA
MANILRKIIENDKGEIKKLEKTAKKVESYADAMAALSDEELQAKTEEFKQRYQNGESLDQLLPEAFAVVREGSKRVLGLFPYRVQIMGGIVLHHGDVAEMRTGEGKTLTATMPVYLNAISGEGVHVITVNEYLSERDATEMGELYSWLGLSVGINLSSKSPAEKREAYNCDITYSTSSEVGFDYLRDNMVVRKENMVQRPLNFALVDEVDSVLIDEARTPLIVSGPVSSETNQLYHRADAFVKTLTEDDYAIDTPTKTIGLNDSGIDKAEEFFNLENLYDIDNVALTHYIDNALRANYIMLRDIDYVVSPEQEILIVDQFTGRTMEGRRFSDGLHQAIEAKEGVPVQEETKTSASITYQNMFRMYKKLSGMTGTGKTEEDEFREIYNMRVIPIPTNRPIQRIDHDDLLYSTLDAKFRAVVQDVKRRYEKGQPVLIGTVAVETSDLISKMLVDAGIPHEVLNAKNHEKEAHIIMNAGQRGAVTIATNMAGRGTDIKLGEGVLELGGLCVIGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDELMRRFGSDRIKHVLERLNADDEDIVIKSRMLTRQVESAQKRVEGNNYDTRKQVLQYDDVMREQREIIYAERYDVITAERDLEPEIKAMIKRTINRTVDGHSRNDQEEALKGILNFARQALVPEDAISLEDLKEVGEVTKRSVNYDAIKVYLTELADNVYDRQIKKLRSEEAIREFQKVLILMVVDNKWTDHIDALDQLRNAVGMRGYAQNNPIVEYQSESFKMFQDMIGAIEYDVTRTMMKAQIHEQSREHVNERVSTTATGNIQAHQADANGQEIDFSKVGRNDFCPCGSGKKFKNCHGRKQF
>NZ_LT604076.1|WP_011226532.1|1478119_1479151_-|3-deoxy-7-phosphoheptulonate-synthase
MVFKAVSEKIDFDAVKESTTLTGEALAKKQARDKELEAIIKGEDNRTLLVIGPCSSDNEDAVLDYAHRLAKLQEEVKDKVFMVMRVYTAKPRTNGDGYKGLVHQPDAEGKPNLINGIKAVRNLHYRVITETGITTADEMLYPENLPLVDDLVSYIAIGARSVEDQQHRFVASGIDVPTGMKNPTSGNLNIMFNGIYAAQNKQDFLFNGEEVQTSGNPLAHAILRGSTNEYGKNIPNFYYDDILDTINTYEKMGLQNPFIVIDTNHDNSGKRYLEQVRIVRQTLINRDWNEKINKFARGFMIESYLEDGRQDTPEIYGKSITDPCLGWDNTEQLIREIHATLSK
>NZ_LT604076.1|WP_087010164.1|1476990_1478022_-|3-deoxy-7-phosphoheptulonate-synthase
MGIHKISSLIDTAEVRKAHALTGDDLAKKQVNDSALAKIIKGEDDRLLLVIGPCSSDNEKAVLDYAHRLSKLQEEVKDKIFIVMRVYTAKPRTNGDGYKGLVHQADSEGATDLITGIKAVRRLQSRIIRETGLPLADEMLYPTNLIYFEDLLSYHAIGARSVEDQEHRFVASGLDVPTGLKNPTSGNLNVMFNAIYAAHNEQEFIYNGHEVKTDGNPLAHAILRGSSNEYGQNEVNYHYEDLVKALDKYSEFGLENPFILVDTNHDNSGKNFMEQIRIVREVLLNREWDKRIADTVRGFMIESYLEDGRQDTPEVYGKSITDPCLGWEKTVNLIREIHTTLSK
>NZ_LT604076.1|WP_002947698.1|1476627_1476987_-|holo-ACP-synthase
MIFGHGIDLQEISAVKKAYDRNPRFAKKVLTPKEWERFESLSGERQMSFLAGRWAGKEAFSKAWGTGIGAVSFKDIEILNNDKGAPVVTQSPFEGNVFISISHSGDFVQASVILEKNKR
>NZ_LT604076.1|WP_087010163.1|1475503_1476607_-|alanine-racemase
MIASLHRPTLAKVDLSAISENIEQVVSHIPKQVQTFAVVKANAYGHGAVEVAKHVSKQVDGFCVSNLDEALELRQAGIEQPILILGVVLPDGVPLAIQENISLTVASLEWLALAQKQGLDLTGLTCHIKVDSGMGRIGVRNLKDADNLIAGLKALGADVEGIFTHFATADEADDSKFKRQLSFFTDLVDNLTDRPRLVHASNSATSIWHATTVFNTVRLGVVIYGLNPSGSVLELPYNIQPALSLETALIHVKTLPAGQDVGYGATYTTTDEEVIGTLPIGYADGWTRDLQGFHVIVDGQLCPIVGRVSMDQITVRLPKVYPLGTPVTLMGENGGASITATEVAEKRGTINYEVLCLLSDRVPRSYD
>NZ_LT604076.1|WP_087010162.1|1473356_1475375_-|ATP-dependent-DNA-helicase-RecG
MIQLDSPIADLKGFGPKSAEKFTKLDLHTVGDLLLYFPFRYEDFKSKSIFELMDGEKAVITGTVVTPANVQYYGFKRNRLSFKIKQGEAVIAINFFNQPYLVDKFEMGAEVAIFGKWDRKKSAVTGMKVLAHVEDDMQPVYHVAQGVSQAQLIKAIKVAFDSGALNLLEESLPQVLMDKYRLMGRQEAVRVMHFPKDLAEYKQALRRIKFEELFYFQMNLQVLKAENKSETNGLAISYDEVKIKAKIATLPFPLTKAQERSLSEILADMKSGAHMNRLLQGDVGSGKTVIASLAMYGAYTAGLQSALMVPTEILAEQHYQSLKGLFPELKVVLLTSGMKMADKKVALSKIESGEAQMIVGTHSLIQDAVIYHKLGLVITDEQHRFGVNQRRIFREKGDNPDVLMMTATPIPRTLAITAFGEMDVSIIDQMPAGRKTIITRWVKHEQLDTVLTWIKSELEKDAQVYFISPLIEESESLDLKNAVALHQELTEFFGDSATVALMHGRMKNDEKDQIMQDFKDKKSQILVSTTVIEVGVNVPNATVMVIMDADRFGLSQLHQLRGRVGRGDKQSYCVLVANPKNDTGKKRMQAMCETTDGFVLAEEDLKMRGSGEIFGTRQSGIPEFQVADIVEDYNILEEARRMASQIVSDPNWRENPDWQVLEAHLRNQAEFD
>NZ_LT604076.1|WP_087010169.1|1486491_1487934_+|sucrose-6-phosphate-hydrolase
MNLPTEVRYRPYTDWIDGEKTKIKENVGKSPWRASYHIEPETGLLNDPNGFSYFNGKFQLFYQSWPFGAAHGLKQWVHTESEDLVHFTETGVKLLPDHENDSHGAYSGSAYQIGDKLFIFYTGNVRDENWIRDPRQIGAWMDKNYKIKKIDKVLIKKPTDVTEHFRDPQIFDYKGQFYAIIGAQNHNKQGFIKFYKAVDNDVENWVEVGDLDFGGTGSEYMIECPNIVFVDGKPVLLYCPQGLDKAELDYNNIYPNTYKIFQDFDPEKAALVGGTPIINLDYGFEAYATQGFNTPDGRALIVSWIGLPDVDYPTDKYDYQGAMSLVKELSIKDGKLYQYPVEAITSLRTRQEDFSEKTATTNTYELELNFQANTQTELVLFADQEGNGLSLTVDTAKGKVILDRSKAGEQYATDFGTSRECTLDAGQAATANIFVDNSIVEIFFNKGEKVFTSRVFPSAEQTGIKVASGNVSGHYFDLKY
>NZ_LT604076.1|WP_087010170.1|1487942_1488908_+|LacI-family-DNA-binding-transcriptional-regulator
MVAKLTDVAELAGVSPTTVSRVINKKGYLSQKTIDKVHAAMQELNYKPNNLARGLKGKSAKLVGLIFPNISNIFYAELIERLEDELFKQGYKTIICNSEHDPNKEKDYLEMLSANQCDGIISSSHNLGIEDYEKVEAPIIAFDRNLAPKIPIISSDNFKGGKLAAKTLVKAGCQRIVMITGNDNSDSPTGLRQLGFNYELNKQGIVCPVPNDLSIMRRELEIKSIICREKPDGIFVSDDLTAILVIKVARQLELSIPNDLKIIGYDGTAFIRHFYPELTTIQQPLDEIAKLCVEILLKKIKGEIVSRDYVLPINLISGSSI
>NZ_LT604076.1|WP_002951890.1|1488997_1489432_-|transcription-antitermination-factor-NusB
MTNIFKDSRRDLRERAFQTLFALEFGGEALDQAYFAYTYDKPIDEETEVDLPSFLLSLVTGVREELPQLDSQIEEKLKEGWSLSRLIMTDRTLLRLGLYEITSFEETPGRVAINEIIEIAKKYSDKTSAKFINGVLSQFVTDEA
>NZ_LT604076.1|WP_002951891.1|1489424_1489814_-|Asp23/Gls24-family-envelope-stress-response-protein
MTTENIGEIVIAPRVLEVITGIAATKVDGVYALQNKNVTDGLSKTSLGRGVYLQTEEDGTVNVDIYVSLQYGVNVPAVSIEIQKAIKTAVYDMAEVLISEVNVHVESIVTEKSQKPDLAELFNEDFLND
>NZ_LT604076.1|WP_011227545.1|1489884_1490445_-|elongation-factor-P
MIEASKLRAGMTFVTNDGKLLKVLEASHHKPGKGNTIMRMKLRDVRSGSTFDTSYRPEEKFEQAIIETVPAQYLYQMDDTAYFMNTETYDQYEIPVVNVQEELKFILENSDVKIQFYGTEVIGVQVPTTVELTVTETQPSIKGATVTGSGKPATLETGLVVNVPDFIEAGQKLVINTVEGTYVSRA
>NZ_LT604076.1|WP_002951893.1|1490557_1491013_-|hypothetical-protein
MTNRLSWQDYFMANAELISKRSTCDRAFVGAVLVKDKRIIATGYNGGVSEADNCNEVGHYMEDGHCIRTVHAEMNALIQCAKEGISTKNTEIYVTHFPCINCTKALLQAGVVKITYKANYRPHAFAIELMEQKGVSYVQHDVPEVHLGMDD
>NZ_LT604076.1|WP_087010171.1|1491031_1492093_-|aminopeptidase-P-family-protein
MQRRLERFDAKLAQSGLDALLVTGQNNIYYLTDFWGTNATVFITKNRRLFLTDSRYTLIAKQSVHGFDIIESKDPLKDIVKFVEVDKLETIGFDNQVSFAYYQALQAIFEGYTLLPQTNFMEELRMIKDEKELATIRKACSISDRAFIDVLDFIKPGQTTELQVANFLDFRMREYGASGISFESIIASGYRSAMPHGVASDKVIQSGETLTMDFGCYYNHYVSDMTRTIHIGETTDEEREIYDIVLRSNRALIDATKAGMTRRDYDKVARDVIVEAGYGDYFTHGIGHGIGLDIHEIPYFGNSDETIEAGMVLTDEPGIYLADKYGVRIEDDIIITENGCEVITLAPKELIVL
>NZ_LT604076.1|WP_002951896.1|1492281_1492710_-|hypothetical-protein
MIRVSDLSGREVILRKLLSFLILSIFAATILVLELIFYKYYVQHVDFPLWVYVRQIYVYFLAYGTFIYMVSTLIILLLKNTLTAFVTVYFGVTGMTFFTLYLASLGDTMTNLMTYVPLSFMRAVFTSGQQFFSLRDAFVLFA
>NZ_LT604076.1|WP_087010172.1|1493315_1493705_-|ATP-binding-cassette-domain-containing-protein
MDNISLTLKKGNIAGLIGNNGAGKTTLMKLISGILERPNGTIDLNTKTVGALIEAPALYPNMTVEANLKFYCRLYHKDYSSIDCYKEDLEVATYLKRKASKLSLGMKQRVGLFIALITSDEFILLDEPT
>NZ_LT604076.1|WP_002946571.1|1493892_1494084_-|hypothetical-protein
MTPLKGPDMEKKNMDVMTMNKFDGLSIDKLSEIVGGNVPYDIGYGVGPVSYIAVEILKLRKIR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_LT604076_1	1.2\|760795\|22\|NZ_LT604076\|CRISPRCasFinder	760795-760816	22	NZ_LT604076.1	760840-760861	1	0.955

1. spacer 1.2|760795|22|NZ_LT604076|CRISPRCasFinder matches to position: 760840-760861, mismatch: 1, identity: 0.955

catgcatattgtccatattgtg	CRISPR spacer
catgcatattatccatattgtg	Protospacer
**********.***********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_LT604076_1	1.2\|760795\|22\|NZ_LT604076\|CRISPRCasFinder	760795-760816	22	NZ_KX138409	Lactococcus lactis strain NCDO712 plasmid pNZ712, complete sequence	24509-24530	1	0.955
NZ_LT604076_1	1.2\|760795\|22\|NZ_LT604076\|CRISPRCasFinder	760795-760816	22	NC_009137	Lactococcus lactis subsp. lactis bv. diacetylactis plasmid pDBORO, complete sequence	13951-13972	1	0.955
NZ_LT604076_1	1.2\|760795\|22\|NZ_LT604076\|CRISPRCasFinder	760795-760816	22	NC_017484	Lactococcus lactis subsp. lactis CV56 plasmid pCV56C, complete sequence	20614-20635	1	0.955
NZ_LT604076_1	1.2\|760795\|22\|NZ_LT604076\|CRISPRCasFinder	760795-760816	22	NZ_CP023393	Lactococcus raffinolactis strain WiKim0068 plasmid pWiKim0068-1, complete sequence	18250-18271	1	0.955
NZ_LT604076_1	1.2\|760795\|22\|NZ_LT604076\|CRISPRCasFinder	760795-760816	22	NZ_CP016699	Lactococcus lactis subsp. lactis strain 275 plasmid p275A, complete sequence	82501-82522	1	0.955
NZ_LT604076_1	1.2\|760795\|22\|NZ_LT604076\|CRISPRCasFinder	760795-760816	22	NZ_CP016700	Lactococcus lactis subsp. lactis strain 275 plasmid p275B, complete sequence	13792-13813	1	0.955
NZ_LT604076_1	1.2\|760795\|22\|NZ_LT604076\|CRISPRCasFinder	760795-760816	22	NZ_CP043526	Lactococcus lactis subsp. lactis bv. diacetylactis strain SD96 plasmid pSD96_02, complete sequence	17721-17742	1	0.955
NZ_LT604076_1	1.2\|760795\|22\|NZ_LT604076\|CRISPRCasFinder	760795-760816	22	NC_017496	Lactococcus lactis subsp. cremoris A76 plasmid pQA554, complete sequence	9717-9738	1	0.955
NZ_LT604076_3	3.1\|1486320\|28\|NZ_LT604076\|CRISPRCasFinder	1486320-1486347	28	NZ_CP015439	Anoxybacillus amylolyticus strain DSM 15939 plasmid pDSM15939_1, complete sequence	128570-128597	5	0.821
NZ_LT604076_3	3.1\|1486320\|28\|NZ_LT604076\|CRISPRCasFinder	1486320-1486347	28	MH920640	Synechoccus phage S-E7, complete genome	139747-139774	5	0.821
NZ_LT604076_3	3.1\|1486320\|28\|NZ_LT604076\|CRISPRCasFinder	1486320-1486347	28	MH920639	Synechoccus phage S-P4, partial genome	150187-150214	5	0.821
NZ_LT604076_3	3.1\|1486320\|28\|NZ_LT604076\|CRISPRCasFinder	1486320-1486347	28	HQ634189	Cyanophage Syn30 genomic sequence	50446-50473	5	0.821
NZ_LT604076_3	3.1\|1486320\|28\|NZ_LT604076\|CRISPRCasFinder	1486320-1486347	28	NZ_CP017864	Campylobacter jejuni strain IF1100 plasmid pCJDM100, complete sequence	3166-3193	6	0.786
NZ_LT604076_3	3.1\|1486320\|28\|NZ_LT604076\|CRISPRCasFinder	1486320-1486347	28	MF041990	Lactobacillus phage phiEF-1.1, complete genome	12839-12866	6	0.786

1. spacer 1.2|760795|22|NZ_LT604076|CRISPRCasFinder matches to NZ_KX138409 (Lactococcus lactis strain NCDO712 plasmid pNZ712, complete sequence) position: , mismatch: 1, identity: 0.955

catgcatattgtccatattgtg	CRISPR spacer
catgcatattatccatattgtg	Protospacer
**********.***********

2. spacer 1.2|760795|22|NZ_LT604076|CRISPRCasFinder matches to NC_009137 (Lactococcus lactis subsp. lactis bv. diacetylactis plasmid pDBORO, complete sequence) position: , mismatch: 1, identity: 0.955

catgcatattgtccatattgtg	CRISPR spacer
catgcatattatccatattgtg	Protospacer
**********.***********

3. spacer 1.2|760795|22|NZ_LT604076|CRISPRCasFinder matches to NC_017484 (Lactococcus lactis subsp. lactis CV56 plasmid pCV56C, complete sequence) position: , mismatch: 1, identity: 0.955

catgcatattgtccatattgtg	CRISPR spacer
catgcatattatccatattgtg	Protospacer
**********.***********

4. spacer 1.2|760795|22|NZ_LT604076|CRISPRCasFinder matches to NZ_CP023393 (Lactococcus raffinolactis strain WiKim0068 plasmid pWiKim0068-1, complete sequence) position: , mismatch: 1, identity: 0.955

catgcatattgtccatattgtg	CRISPR spacer
catgcatattatccatattgtg	Protospacer
**********.***********

5. spacer 1.2|760795|22|NZ_LT604076|CRISPRCasFinder matches to NZ_CP016699 (Lactococcus lactis subsp. lactis strain 275 plasmid p275A, complete sequence) position: , mismatch: 1, identity: 0.955

catgcatattgtccatattgtg	CRISPR spacer
catgcatattatccatattgtg	Protospacer
**********.***********

6. spacer 1.2|760795|22|NZ_LT604076|CRISPRCasFinder matches to NZ_CP016700 (Lactococcus lactis subsp. lactis strain 275 plasmid p275B, complete sequence) position: , mismatch: 1, identity: 0.955

catgcatattgtccatattgtg	CRISPR spacer
catgcatattatccatattgtg	Protospacer
**********.***********

7. spacer 1.2|760795|22|NZ_LT604076|CRISPRCasFinder matches to NZ_CP043526 (Lactococcus lactis subsp. lactis bv. diacetylactis strain SD96 plasmid pSD96_02, complete sequence) position: , mismatch: 1, identity: 0.955

catgcatattgtccatattgtg	CRISPR spacer
catgcatattatccatattgtg	Protospacer
**********.***********

8. spacer 1.2|760795|22|NZ_LT604076|CRISPRCasFinder matches to NC_017496 (Lactococcus lactis subsp. cremoris A76 plasmid pQA554, complete sequence) position: , mismatch: 1, identity: 0.955

catgcatattgtccatattgtg	CRISPR spacer
catgcatattatccatattgtg	Protospacer
**********.***********

9. spacer 3.1|1486320|28|NZ_LT604076|CRISPRCasFinder matches to NZ_CP015439 (Anoxybacillus amylolyticus strain DSM 15939 plasmid pDSM15939_1, complete sequence) position: , mismatch: 5, identity: 0.821

aacaaaatttgtttttgaaaacgcttca	CRISPR spacer
taaagaatttttttttgaaaacgcttta	Protospacer
 * *.***** ***************.*

10. spacer 3.1|1486320|28|NZ_LT604076|CRISPRCasFinder matches to MH920640 (Synechoccus phage S-E7, complete genome) position: , mismatch: 5, identity: 0.821

aacaaaatttgtttttgaaaacgcttca-	CRISPR spacer
aacacaatttgtttttgaaaa-gttatat	Protospacer
**** **************** *.* .*

11. spacer 3.1|1486320|28|NZ_LT604076|CRISPRCasFinder matches to MH920639 (Synechoccus phage S-P4, partial genome) position: , mismatch: 5, identity: 0.821

aacaaaatttgtttttgaaaacgcttca-	CRISPR spacer
aacacaatttgtttttgaaaa-gttatat	Protospacer
**** **************** *.* .*

12. spacer 3.1|1486320|28|NZ_LT604076|CRISPRCasFinder matches to HQ634189 (Cyanophage Syn30 genomic sequence) position: , mismatch: 5, identity: 0.821

aacaaaatttgtttttgaaaacgcttca-	CRISPR spacer
aacacaatttgtttttgaaaa-gttatat	Protospacer
**** **************** *.* .*

13. spacer 3.1|1486320|28|NZ_LT604076|CRISPRCasFinder matches to NZ_CP017864 (Campylobacter jejuni strain IF1100 plasmid pCJDM100, complete sequence) position: , mismatch: 6, identity: 0.786

aacaaaatttgtttttgaaaacgcttca	CRISPR spacer
gaaaaaatttgtttttcaaaaagcttat	Protospacer
.* ************* **** ****

14. spacer 3.1|1486320|28|NZ_LT604076|CRISPRCasFinder matches to MF041990 (Lactobacillus phage phiEF-1.1, complete genome) position: , mismatch: 6, identity: 0.786

aacaaaatttgtttttgaaaacgcttca	CRISPR spacer
aacaaaatttatgtttgaaaacggatgc	Protospacer
**********.* **********  *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

587316 : 597265

Streptococcus_phage(85.71%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004197422.1\|587316_588318_+	catabolite control protein A	C6ZCU4	Enterobacteria_phage	3.7e-21	27.3
WP_014608125.1\|588376_588574_+	hypothetical protein	NA	NA	NA	NA
WP_087009786.1\|588679_589444_+	MmcQ/YjbR family DNA-binding protein	NA	NA	NA	NA
WP_002950249.1\|589458_590574_+	glycerate kinase	W6LM47	Streptococcus_phage	8.9e-157	99.6
WP_087009787.1\|590612_591068_-	YueI family protein	W6LLD2	Streptococcus_phage	2.9e-66	82.8
WP_011225708.1\|591275_592580_+	phosphopyruvate hydratase	W6LP63	Streptococcus_phage	3.2e-246	99.5
WP_002947233.1\|593079_595266_-	LTA synthase family protein	W6LM83	Streptococcus_phage	0.0e+00	99.2
WP_002950251.1\|595427_596591_+	class I SAM-dependent rRNA methyltransferase	W6LLI2	Streptococcus_phage	5.9e-220	99.5
WP_087009788.1\|596587_597265_+	type I 3-dehydroquinate dehydratase	W6LP76	Streptococcus_phage	1.3e-121	99.6

DBSCAN-SWA_2

748058 : 762336

Streptococcus_phage(25.0%)

transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_087009855.1\|748058_748712_+	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	2.2e-62	54.9
WP_002950528.1\|748711_749155_+	6-carboxytetrahydropterin synthase QueD	J9PV91	Bacillus_phage	7.9e-40	55.6
WP_087009856.1\|749147_749864_+	7-carboxy-7-deazaguanine synthase QueE	E7DN68	Pneumococcus_phage	1.2e-61	47.7
WP_087009857.1\|749983_750475_+	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	8.1e-46	56.3
WP_087009858.1\|751294_751483_+\|protease	serine protease	NA	NA	NA	NA
WP_023909583.1\|751687_752458_+	DUF1003 domain-containing protein	NA	NA	NA	NA
WP_087009859.1\|752438_753329_+	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	4.3e-05	28.1
WP_014621467.1\|753325_754300_+	YvcK family protein	A1IMD5	Streptococcus_phage	4.0e-137	73.8
WP_002945081.1\|754296_755208_+	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	7.1e-104	64.7
WP_087009860.1\|755225_755372_+	C69 family dipeptidase	NA	NA	NA	NA
WP_157659033.1\|755394_755976_+	C69 family dipeptidase	NA	NA	NA	NA
WP_087009861.1\|755982_756219_+	C69 family dipeptidase	NA	NA	NA	NA
WP_087009862.1\|756518_756725_+	cold shock domain-containing protein	Q9AZD3	Lactococcus_phage	3.0e-10	47.8
WP_011681063.1\|757004_757205_+	cold-shock protein	Q9AZD3	Lactococcus_phage	2.9e-26	89.4
WP_087009863.1\|757537_758713_+\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	3.1e-35	27.4
WP_087009864.1\|758833_760969_-	copper-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	2.4e-65	32.7
WP_087009865.1\|761160_762336_-\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	9.1e-35	28.0

DBSCAN-SWA_3

1281961 : 1289703

Streptococcus_phage(83.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011226366.1\|1281961_1283914_-	DNA topoisomerase (ATP-hydrolyzing) subunit B	G3M9Z3	Bacillus_virus	9.8e-143	45.7
WP_024703964.1\|1283914_1284475_-	HAD-IA family hydrolase	NA	NA	NA	NA
WP_014608597.1\|1284560_1285256_-	LrgB family protein	NA	NA	NA	NA
WP_087010086.1\|1285248_1285623_-	CidA/LrgA family protein	NA	NA	NA	NA
WP_087010087.1\|1285902_1286256_-	arsenate reductase family protein	M1PLC0	Streptococcus_phage	3.4e-38	63.2
WP_022097011.1\|1286290_1286785_-	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	1.9e-34	45.1
WP_087010088.1\|1286842_1288021_-	phosphoglycerate dehydrogenase	M1NSB9	Streptococcus_phage	2.2e-177	79.1
WP_087010089.1\|1288039_1288597_-	GNAT family N-acetyltransferase	M1PSC3	Streptococcus_phage	4.1e-54	57.9
WP_011227455.1\|1288608_1289703_-	3-phosphoserine/phosphohydroxythreonine transaminase	M1Q1P2	Streptococcus_phage	7.4e-172	81.5

DBSCAN-SWA_4

1369491 : 1427147

Bacillus_virus(28.57%)

tRNA,bacteriocin,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_087010126.1\|1369491_1371591_-\|protease	ATP-dependent Clp protease ATP-binding subunit	H6X3M6	Enterobacteria_phage	3.2e-123	39.7
WP_022096463.1\|1372305_1373397_-	nucleotidyltransferase	NA	NA	NA	NA
WP_022096462.1\|1373403_1374150_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_011227491.1\|1374468_1374822_-	ribosome silencing factor	NA	NA	NA	NA
WP_087010127.1\|1374845_1375436_-	HD domain-containing protein	NA	NA	NA	NA
WP_065972527.1\|1375432_1376065_-	nicotinate-nucleotide adenylyltransferase	G3MA22	Bacillus_virus	2.1e-17	31.0
WP_002951701.1\|1376168_1376486_-	ribosome assembly RNA-binding protein YhbY	NA	NA	NA	NA
WP_087010128.1\|1376724_1377843_-	ribosome biogenesis GTPase YqeH	NA	NA	NA	NA
WP_002951705.1\|1377842_1378370_-	YqeG family HAD IIIA-type phosphatase	NA	NA	NA	NA
WP_087010129.1\|1378506_1379421_-	EamA family transporter	NA	NA	NA	NA
WP_011226448.1\|1379497_1379881_-	hypothetical protein	NA	NA	NA	NA
WP_002946582.1\|1379978_1381421_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	NA	NA	NA	NA
WP_087010130.1\|1381420_1382887_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	NA	NA	NA	NA
WP_002884769.1\|1382886_1383189_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	NA	NA	NA	NA
WP_041827766.1\|1383328_1383583_-	glycosyl transferase	NA	NA	NA	NA
WP_002951711.1\|1383595_1383805_-	hypothetical protein	NA	NA	NA	NA
WP_172838697.1\|1384120_1385533_-	6-phospho-beta-glucosidase	NA	NA	NA	NA
WP_084829818.1\|1385714_1386224_-	peptide-methionine (S)-S-oxide reductase MsrA	NA	NA	NA	NA
WP_041828318.1\|1386235_1387084_-	MetQ/NlpA family ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_002946999.1\|1387207_1387759_-	cysteine hydrolase	G3MA16	Bacillus_virus	2.6e-24	40.3
WP_002951720.1\|1387821_1388607_-	GTP-sensing pleiotropic transcriptional regulator CodY	NA	NA	NA	NA
WP_002951721.1\|1388866_1390081_-	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_002946987.1\|1390435_1390888_+	universal stress protein	NA	NA	NA	NA
WP_172838681.1\|1391709_1391883_-	hypothetical protein	NA	NA	NA	NA
WP_041828320.1\|1391943_1392318_-	membrane protein	NA	NA	NA	NA
WP_002946980.1\|1392529_1393330_-	pyruvate formate lyase-activating protein	A0A2P0VNQ0	Tetraselmis_virus	2.9e-24	31.8
WP_157821721.1\|1393517_1393646_-	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_087010131.1\|1394319_1395651_-	HlyC/CorC family transporter	NA	NA	NA	NA
WP_087010132.1\|1395763_1396546_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	7.7e-14	28.0
WP_087010133.1\|1397164_1399231_-	sodium:proton antiporter	NA	NA	NA	NA
WP_011226461.1\|1399239_1399482_-	hypothetical protein	NA	NA	NA	NA
WP_011226462.1\|1399478_1400027_-	SAM-dependent methyltransferase	A0A2H4PQV0	Staphylococcus_phage	3.5e-37	44.1
WP_011226463.1\|1400023_1400968_-	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	8.6e-36	48.3
WP_022096499.1\|1401052_1402129_-	PDZ domain-containing protein	NA	NA	NA	NA
WP_011226465.1\|1402106_1402604_-	pantetheine-phosphate adenylyltransferase	A0A1B1IVQ3	uncultured_Mediterranean_phage	8.3e-14	28.8
WP_087010134.1\|1402637_1403186_-	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	NA	NA	NA	NA
WP_011226467.1\|1403327_1404248_-	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	4.7e-87	52.0
WP_087010135.1\|1404313_1404538_-	DUF4059 family protein	NA	NA	NA	NA
WP_087010136.1\|1404752_1405496_-	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.8e-31	40.9
WP_087010270.1\|1405495_1406284_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_087010137.1\|1406629_1407460_-	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_002947030.1\|1407958_1408192_-	hypothetical protein	NA	NA	NA	NA
WP_087010138.1\|1408489_1409593_-	DNA polymerase IV	NA	NA	NA	NA
WP_002947035.1\|1409871_1412181_+	formate C-acetyltransferase	A0A2P0VNR5	Tetraselmis_virus	1.1e-111	32.4
WP_087010139.1\|1413301_1414057_-	iron export ABC transporter permease subunit FetB	NA	NA	NA	NA
WP_087010140.1\|1414053_1414704_-	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	1.2e-20	31.1
WP_087010141.1\|1414906_1415863_-	serine hydrolase	NA	NA	NA	NA
WP_011681560.1\|1415862_1416618_-	peptidase	NA	NA	NA	NA
WP_014608659.1\|1416899_1417262_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_002951781.1\|1417348_1418212_-	aquaporin family protein	M1H4F4	Acanthocystis_turfacea_Chlorella_virus	3.9e-27	34.4
WP_087010142.1\|1418332_1420600_+	Xaa-Pro dipeptidyl-peptidase	NA	NA	NA	NA
WP_002951783.1\|1420679_1421060_-	hypothetical protein	NA	NA	NA	NA
WP_157659046.1\|1421184_1421448_-	hypothetical protein	NA	NA	NA	NA
WP_004197070.1\|1421769_1422066_-\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA
WP_087010143.1\|1422230_1423157_-	thioredoxin family protein	NA	NA	NA	NA
WP_087009847.1\|1423350_1424920_+\|transposase	IS3-like element ISSth1b family transposase	A0A0C5AC89	Paenibacillus_phage	2.0e-53	50.9
WP_087010144.1\|1425066_1425321_-\|bacteriocin	ComC/BlpC family leader-containing pheromone/bacteriocin	NA	NA	NA	NA
WP_084829836.1\|1426940_1427147_-\|bacteriocin	ComC/BlpC family leader-containing pheromone/bacteriocin	NA	NA	NA	NA

DBSCAN-SWA_5

1551226 : 1589509

Streptococcus_phage(22.22%)

tRNA,bacteriocin,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011681659.1\|1551226_1552369_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	2.7e-84	43.4
WP_149036660.1\|1552622_1553093_-\|transposase	IS200/IS605 family transposase	A0A0A8WIU6	Clostridium_phage	1.2e-09	31.1
WP_002953513.1\|1553273_1553408_-	50S ribosomal protein L34	NA	NA	NA	NA
WP_087010184.1\|1554296_1555346_-	protein jag	NA	NA	NA	NA
WP_002953525.1\|1555357_1556164_-	membrane protein insertase YidC	NA	NA	NA	NA
WP_002953528.1\|1556278_1556614_-	ribonuclease P protein component	NA	NA	NA	NA
WP_087010185.1\|1556698_1558084_-	argininosuccinate lyase	NA	NA	NA	NA
WP_002953531.1\|1558412_1559612_-	argininosuccinate synthase	NA	NA	NA	NA
WP_002953532.1\|1560512_1561967_-\|tRNA	glutamate--tRNA ligase	A0A2K9L481	Tupanvirus	6.9e-08	30.3
WP_002946412.1\|1563292_1563982_-	50S ribosomal protein L1	NA	NA	NA	NA
WP_002953535.1\|1564081_1564507_-	50S ribosomal protein L11	NA	NA	NA	NA
WP_002953536.1\|1564678_1565032_+	DUF3397 domain-containing protein	NA	NA	NA	NA
WP_024704233.1\|1565123_1565621_-	carbonic anhydrase	NA	NA	NA	NA
WP_087010186.1\|1566547_1567909_-	DNA repair protein RadA	NA	NA	NA	NA
WP_002947069.1\|1568086_1568533_-	dUTP diphosphatase	Q332E8	Clostridium_botulinum_C_phage	8.5e-34	50.7
WP_172838685.1\|1569369_1569726_+	NAD(P)H-dependent oxidoreductase	A0A2P0ZL82	Lactobacillus_phage	8.3e-32	55.1
WP_172838686.1\|1569792_1570518_+	DUF438 domain-containing protein	NA	NA	NA	NA
WP_042798905.1\|1571539_1571995_+	MptD family putative ECF transporter S component	NA	NA	NA	NA
WP_087010187.1\|1572226_1573249_+	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_087010188.1\|1573267_1574182_+	UTP--glucose-1-phosphate uridylyltransferase GalU	A0A127AW70	Bacillus_phage	5.9e-74	50.5
WP_087009847.1\|1574275_1575845_+\|transposase	IS3-like element ISSth1b family transposase	A0A0C5AC89	Paenibacillus_phage	2.0e-53	50.9
WP_011226604.1\|1575914_1576589_-\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_011226605.1\|1576579_1577107_-	5-formyltetrahydrofolate cyclo-ligase	NA	NA	NA	NA
WP_087010189.1\|1577175_1578309_-	N-acetyldiaminopimelate deacetylase	NA	NA	NA	NA
WP_002951996.1\|1578387_1579086_-	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase	NA	NA	NA	NA
WP_011681672.1\|1580040_1580874_-	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_002945733.1\|1581242_1581410_+\|bacteriocin	class IIb bacteriocin, lactobin A/cerein 7B family	NA	NA	NA	NA
WP_087010191.1\|1581805_1582324_-	nucleoside deaminase	NA	NA	NA	NA
WP_011226610.1\|1583084_1583477_-	single-stranded DNA-binding protein	A1EAD1	Streptococcus_phage	8.8e-27	49.2
WP_064355726.1\|1583682_1583910_-	sulfurtransferase TusA family protein	NA	NA	NA	NA
WP_087010192.1\|1583924_1584956_-	YeeE/YedE family protein	NA	NA	NA	NA
WP_002952017.1\|1585089_1585713_-\|tRNA	DUF4479 and tRNA-binding domain-containing protein	NA	NA	NA	NA
WP_002945230.1\|1585722_1586037_-	thioredoxin family protein	NA	NA	NA	NA
WP_087010193.1\|1586033_1586318_-	DUF4651 domain-containing protein	NA	NA	NA	NA
WP_002952022.1\|1586417_1587485_+	glutamyl aminopeptidase	NA	NA	NA	NA
WP_011226616.1\|1587500_1588271_+	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	2.8e-32	36.1
WP_087010194.1\|1588300_1588963_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_087010195.1\|1589065_1589509_-\|protease	CAAX protease	NA	NA	NA	NA

DBSCAN-SWA_6

1709376 : 1724948

Streptococcus_phage(30.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_087010229.1\|1709376_1710006_-	hypothetical protein	Q4Z8Z7	Staphylococcus_phage	9.5e-23	64.8
WP_011226701.1\|1710245_1710800_-	LysM peptidoglycan-binding domain-containing protein	A0A0E3XCL7	Enterococcus_phage	3.1e-25	42.2
WP_065972708.1\|1711103_1711898_-	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
WP_002947774.1\|1711890_1712733_-	energy-coupling factor transporter ATPase	W6JKT0	Anomala_cuprea_entomopoxvirus	2.1e-17	26.2
WP_002947776.1\|1712708_1713539_-	energy-coupling factor transporter ATPase	G9BWD6	Planktothrix_phage	4.5e-20	31.3
WP_087010230.1\|1713551_1714094_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
WP_002947779.1\|1714106_1714964_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_087010231.1\|1715022_1716300_-	insulinase family protein	A0A167R9K4	Powai_lake_megavirus	5.6e-22	28.3
WP_087010232.1\|1716301_1717552_-	insulinase family protein	A0A1X9I714	Streptococcus_phage	1.0e-92	39.9
WP_087010233.1\|1717629_1718007_+	S4 domain-containing protein YaaA	A0A1X9I5V8	Streptococcus_phage	1.7e-22	68.4
WP_087010234.1\|1718009_1719110_+	DNA replication/repair protein RecF	NA	NA	NA	NA
WP_011227627.1\|1719278_1720760_-	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	6.8e-96	40.3
WP_087010235.1\|1720936_1721959_-\|tRNA	tryptophan--tRNA ligase	NA	NA	NA	NA
WP_011227628.1\|1722386_1723259_+	YitT family protein	M1Q1P6	Streptococcus_phage	3.7e-33	33.9
WP_002946814.1\|1723325_1724948_+	ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	1.4e-46	25.5

Anti-CRISPR protein detection

Acr_ID: NZ_LT604076.1|WP_087009858.1|751294_751483_+|serine-protease

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_LT604076.1|WP_087009858.1|751294_751483_+|serine-protease

751294_751483_+

62 aa aa

748058-762336

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_LT604076_1	Orphan	1.2\|760795\|22\|NZ_LT604076\|CRISPRCasFinder	760795-760816	22	760840-760861	1

1. spacer 1.2|760795|22|NZ_LT604076|CRISPRCasFinder matches to NZ_LT604076 position: 760840-760861, mismatch: 1

catgcatattgtccatattgtg	CRISPR spacer
catgcatattatccatattgtg	Protospacer
**********.***********

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_LT604076

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

Click the colored protein region to show detailed information