CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_LT992456	Staphylococcus aureus isolate 1_1439 chromosome I	9 crisprs	cas3,csa3,WYL,TnsE_C,DEDDh,DinG	3	1	11	0
NZ_LT992457	Staphylococcus aureus isolate 1_1439 plasmid II	0 crisprs	csa3	0	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_LT992456_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LT992456_1

435142-435222

Orphan

Consensus_repeat	Method
GGGAGTGGGAGAGAAATGATAAAGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_LT992456_1

>merge|NZ_LT992456|1|435142-435222|CRISPRCasFinder
GGGAGTGGGAGAGAAATGATAAAGAATCACTTATGCTTTATTATGTATTGGTTCTTGGGAGTGGGACAGAAATGATAAAGA

>NZ_LT992456|1|1|435142-435222|CRISPRCasFinder
GGGAGTGGGAGAGAAATGATAAAGA	ATCACTTATGCTTTATTATGTATTGGTTCTT
GGGAGTGGGACAGAAATGATAAAGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LT992456.1\|WP_000290492.1\|441043_441424_-\|glycine-cleavage-system-protein-GcvH	unknown	unknown	gnl\|CDD\|234918
NZ_LT992456.1\|WP_000168845.1\|432630_433392_-\|Fe-S-cluster-assembly-ATPase-SufC	unknown	unknown	gnl\|CDD\|223473
NZ_LT992456.1\|WP_000205572.1\|431224_432532_-\|Fe-S-cluster-assembly-protein-SufD	unknown	unknown	gnl\|CDD\|223791
NZ_LT992456.1\|WP_001825559.1\|429868_431119_-\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|131034
NZ_LT992456.1\|WP_000267231.1\|424730_425798_-\|nitronate-monooxygenase	unknown	unknown	gnl\|CDD\|224981
NZ_LT992456.1\|WP_000932205.1\|439985_440864_-\|DUF1963-domain-containing-protein	unknown	unknown	gnl\|CDD\|226395
NZ_LT992456.1\|WP_000571213.1\|437333_438359_-\|methionine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224058
NZ_LT992456.1\|WP_000274033.1\|427220_427535_+\|hypothetical-protein	unknown	unknown	unknown
NZ_LT992456.1\|WP_000732338.1\|435806_436628_-\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
NZ_LT992456.1\|WP_001065802.1\|438608_438905_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NZ_LT992456.1\|WP_001010508.1\|429414_429879_-\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	unknown	unknown	gnl\|CDD\|273918
NZ_LT992456.1\|WP_000582322.1\|425811_426852_-\|DUF21-domain-containing-protein	unknown	unknown	gnl\|CDD\|226911
NZ_LT992456.1\|WP_001183849.1\|433719_434571_+\|DUF368-domain-containing-protein	unknown	unknown	gnl\|CDD\|224946
NZ_LT992456.1\|WP_001018957.1\|438897_439284_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224572
NZ_LT992456.1\|WP_001074405.1\|427866_429264_-\|Fe-S-cluster-assembly-protein-SufB	unknown	unknown	gnl\|CDD\|131035
NZ_LT992456.1\|WP_000520237.1\|436645_437341_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224922
NZ_LT992456.1\|WP_000752917.1\|434804_434999_-\|CsbD-family-protein	unknown	unknown	gnl\|CDD\|225777
NZ_LT992456.1\|WP_001147955.1\|442081_442402_+\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NZ_LT992456.1\|WP_000589549.1\|441581_441938_-\|arsenate-reductase-family-protein	unknown	unknown	gnl\|CDD\|239334
NZ_LT992456.1\|WP_000422911.1\|442551_443091_-\|nitroreductase	unknown	unknown	gnl\|CDD\|380312

Protein	Function_ID	Function_description	E-value
NZ_LT992456.1\|WP_000290492.1\|441043_441424_-\|glycine-cleavage-system-protein-GcvH	gnl\|CDD\|234918	PRK01202, PRK01202, glycine cleavage system protein GcvH.	1.19798e-69
NZ_LT992456.1\|WP_000168845.1\|432630_433392_-\|Fe-S-cluster-assembly-ATPase-SufC	gnl\|CDD\|223473	COG0396, sufC, Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones].	1.29081e-150
NZ_LT992456.1\|WP_000205572.1\|431224_432532_-\|Fe-S-cluster-assembly-protein-SufD	gnl\|CDD\|223791	COG0719, SufB, Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones].	8.11734e-136
NZ_LT992456.1\|WP_001825559.1\|429868_431119_-\|cysteine-desulfurase	gnl\|CDD\|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_LT992456.1\|WP_000267231.1\|424730_425798_-\|nitronate-monooxygenase	gnl\|CDD\|224981	COG2070, COG2070, Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only].	2.6112e-111
NZ_LT992456.1\|WP_000932205.1\|439985_440864_-\|DUF1963-domain-containing-protein	gnl\|CDD\|226395	COG3878, COG3878, Uncharacterized protein conserved in bacteria [Function unknown].	1.16986e-75
NZ_LT992456.1\|WP_000571213.1\|437333_438359_-\|methionine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224058	COG1135, AbcC, ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism].	2.03316e-170
NZ_LT992456.1\|WP_000732338.1\|435806_436628_-\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	5.3847e-113
NZ_LT992456.1\|WP_001065802.1\|438608_438905_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	3.92494e-14
NZ_LT992456.1\|WP_001010508.1\|429414_429879_-\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	gnl\|CDD\|273918	TIGR01994, Iron-sulfur_cluster_assembly_scaffold_protein_IscU, SUF system FeS assembly protein, NifU family. Three iron-sulfur cluster assembly systems are known so far. ISC is broadly distributed while NIF tends to be associated with nitrogenase in nitrogen-fixing bacteria. The most recently described is SUF, believed to be important to maintain the function during aerobic stress of enzymes with labile Fe-S clusters. It is fairly widely distributed. This family represents one of two different proteins proposed to act as a scaffold on which the Fe-S cluster is built and from which it is transferred. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	6.42482e-68
NZ_LT992456.1\|WP_000582322.1\|425811_426852_-\|DUF21-domain-containing-protein	gnl\|CDD\|226911	COG4536, CorB, Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism].	2.87954e-160
NZ_LT992456.1\|WP_001183849.1\|433719_434571_+\|DUF368-domain-containing-protein	gnl\|CDD\|224946	COG2035, COG2035, Predicted membrane protein [Function unknown].	2.68358e-76
NZ_LT992456.1\|WP_001018957.1\|438897_439284_-\|hypothetical-protein	gnl\|CDD\|224572	COG1658, COG1658, Small primase-like proteins (Toprim domain) [DNA replication, recombination, and repair].	4.21303e-36
NZ_LT992456.1\|WP_001074405.1\|427866_429264_-\|Fe-S-cluster-assembly-protein-SufB	gnl\|CDD\|131035	TIGR01980, UPF0051_protein_slr0074, FeS assembly protein SufB. This protein, SufB, forms a cytosolic complex SufBCD. This complex enhances the cysteine desulfurase of SufSE. The system, together with SufA, is believed to act in iron-sulfur cluster formation during oxidative stress. Note that SufC belongs to the family of ABC transporter ATP binding proteins, so this protein, encoded by an adjacent gene, has often been annotated as a transporter component. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_LT992456.1\|WP_000520237.1\|436645_437341_-\|ABC-transporter-permease	gnl\|CDD\|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	1.61333e-99
NZ_LT992456.1\|WP_000752917.1\|434804_434999_-\|CsbD-family-protein	gnl\|CDD\|225777	COG3237, COG3237, Uncharacterized protein conserved in bacteria [Function unknown].	5.95583e-07
NZ_LT992456.1\|WP_001147955.1\|442081_442402_+\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	3.63533e-24
NZ_LT992456.1\|WP_000589549.1\|441581_441938_-\|arsenate-reductase-family-protein	gnl\|CDD\|239334	cd03036, ArsC_like, Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX) function as protein disulfide oxidoreductases, altering the redox state of target proteins via the reversible oxidation of the active site dithiol. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via GRX, through a single catalytic cysteine.	1.06191e-56
NZ_LT992456.1\|WP_000422911.1\|442551_443091_-\|nitroreductase	gnl\|CDD\|380312	cd02135, YdjA-like, nitroreductase family protein similar to Escherichia coli YdjA. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.	3.60721e-49

>NZ_LT992456.1|WP_000752917.1|434804_434999_-|CsbD-family-protein
MADESKFEQAKGNVKETVGNVTDNKNLENEGKEDKASGKAKEFVENAKEKATDFIDKVKGNKGE
>NZ_LT992456.1|WP_001183849.1|433719_434571_+|DUF368-domain-containing-protein
MQQFKWINILKGFAMGTSDLVPGVSGGTIALLLGIYNQFIASISGIFSRRFWPSFTFLIPIIIGMLLAMGSLSNLFNYLLSQHHIPTMFFFGGLIIGIVPYLLKISNYKTSFTTKHYMMVIAGIAILIVITLMNNGDKHAGETLTLSTGLIIKYFIAGMCASSAMLLPGISGSFMLLVFGVYGTVMLAISEFVKLNFAGLPILLAVGFGVLAGFIISSKIIQYFLTHHKLMTFALIIGFVVGSLFAVFPGLPTNIVMWFVSLVVFIIGFIVSLTLGRITAENE
>NZ_LT992456.1|WP_000168845.1|432630_433392_-|Fe-S-cluster-assembly-ATPase-SufC
MASTLEIKDLHVSIEDKEILKGVNLTINTDEIHAIMGPNGTGKSTLSSAIMGHPSYEVTKGEVLLDGVNILELEVDERAKAGLFLAMQYPSEITGVTNADFMRSAINAKREEGQEINLMQFIKKLDKNMDFLDIDKDMAQRYLNEGFSGGEKKRNEILQLMMLEPKFAILDEIDSGLDIDALKVVSKGINQMRGENFGALMITHYQRLLNYITPDKVHVMYAGKVVKSGGPELAKRLEEEGYEWVKEEFGSAE
>NZ_LT992456.1|WP_000205572.1|431224_432532_-|Fe-S-cluster-assembly-protein-SufD
MTTDILNISEEQLVDYSKAHNEPSWMTELRKKALKLTETLEMPKPDKTKLRKWDFDSFKQHDVKGDVYQSLSQLPESVREIIDVDHSKNLVIQHNNTIAYTQVDDNASKDGVIVEGLADALMNHSDLVQKYFMKDAVTVDEHRITALHTALVNGGVFVYVPKNVVVEHPVQYVVLHDDENASFYNHVIIVTEESAEVTYVENYLSNASGEGNQLNIISEVIAGANSNITYGSVDYMDKGFTGHIIRRGITEADASINWALGLMNEGSQIIDNTTNLFGDRSTSSLKSVVVGTGEQKINLTSKIVQYGKETDGYILKHGVMKEHASSVFNGIGYIKHGGTKSIANQESRVLMLSEHARGDANPILLIDEDDVQAGHAASVGRVDPDQLYYLMSRGISQREAERLVIHGFLDPVVRELPIEDVKRQLREVIERKVSK
>NZ_LT992456.1|WP_001825559.1|429868_431119_-|cysteine-desulfurase
MNEVAEHSFDVNEVIKDFPILDQKVNGKRLAYLDSTATSQTPVQVLNVLEDYYKRYNSNVHRGVHTLGSLATDGYENARETVRRFINAKYFEEIIFTRGTTASINLVAHSYGDANVEEGDEIVVTEMEHHANIVPWQQLAKRKNATLKFIPMTADGELNIEDIKQTINDKTKIVAIAHISNVLGTINDVKTIAEIAHQHGAIISVDGAQAAPHMKLDMQEMNADFYSFSGHKMLGPTGIGVLFGKRELLQKMEPIEFGGDMIDFVSKYDATWADLPTKFEAGTPLIAQAIGLAEAIRYLERIGFDAIHKYEQELTIYAYEQMSTIEGIEIYGPPKDRRAGVITFNLQDVHPHDVATAVDTEGVAVRAGHHCAQPLMKWLNVSSTARASFYIYNTKEDIDQLINALKQTKEFFSYEF
>NZ_LT992456.1|WP_001010508.1|429414_429879_-|SUF-system-NifU-family-Fe-S-cluster-assembly-protein
MNFNNLDQLYRSVIMDHYKNPRNKGVLDNGSMTVDMNNPTCGDRIRLTFDIEDGIIKDAKFEGEGCSISMASASMMTQAVKGHSLGEAMQMSQEFTKMMLGEDYVITEEMGDIEALQGVSQFPARIKCATLAWKALEKGTVAKEGKAEGTTEEE
>NZ_LT992456.1|WP_001074405.1|427866_429264_-|Fe-S-cluster-assembly-protein-SufB
MAKKAPDVGDYKYGFHDDDVSIFRSERGLTENIVREISNMKNEPEWMLDFRLKSLKLFYKMPMPQWGGDLSELNFDDITYYVKPSEQAERSWDEVPEEIKRTFDKLGIPEAEQKYLAGVSAQYESEVVYHNMEKELEEKGIIFKDTDSALQENEELFKKYFASVVPAADNKFAALNSAVWSGGSFIYVPKNIKLDTPLQAYFRINSENMGQFERTLIIADEGASVHYVEGCTAPVYTTSSLHSAVVEIIVHKDAHVRYTTIQNWANNVYNLVTKRTFVYENGNMEWVDGNLGSKLTMKYPNCVLLGEGAKGSTLSIAFAGKGQVQDAGAKMIHKAPNTSSTIVSKSISKNGGKVIYRGIVHFGRKAKGARSNIECDTLILDNESTSDTIPYNEVFNDQISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAVEMNRLIKFEMEGSIG
>NZ_LT992456.1|WP_000274033.1|427220_427535_+|hypothetical-protein
MYFVLAIFTIISASVSLGYSIQACASSHNINAYYALSRSLPLFLLAIFSLVIHSAIFLITISIAMILVQFLDAIVGYKSNDVFKTYGPLATSVVNLILLIVFLF
>NZ_LT992456.1|WP_000582322.1|425811_426852_-|DUF21-domain-containing-protein
MIIAIIILIFISFFFSGSETALTAANKTKFKTEADKGDKKAKGIVKLLEKPSEFITTILIGNNVANILLPTLVTIMALRWGISVGIASAVLTVVIILISEVIPKSVAATFPDKITRLVYPIINICVIVFRPITLLLNKLTDSINRCLSKGQPQEHQFSKEEFKTMLAIAGHEGALNEIETSRLEGVINFENLKVKDVDTTPRINVTAFASNATYEEVYETVMNKPYTRYPVYEGDIDNIIGVFHSKYLLAWSNKKEDQITNYSAKPLFVNEHNKAEWVLRKMTISRKHLAIVLDEFGGTEAIVSHEDLIEELLGMEIEDEMDKKEKEKLSQQQIQFQQRKNRNVSI
>NZ_LT992456.1|WP_000267231.1|424730_425798_-|nitronate-monooxygenase
MWNKNRLTQMLSIEFPIIQAGMAGSTTPKLVASVSNSGGLGTIGAGYFNTQQLEDEIDYVRQLTSNSFGVNVFVPSQQSYTSNQIENMNAWLKPYRRALHLEEPVVKITEEQQFKCHIDTIIKKQVPVCCFTFGIPNESIIKRLKEANIKLIGTATSVDEAIANEKAGMDAIVAQGSEAGGHRGSFLKPKNQLPMVGTISLVPQIVDVVSIPVIAAGGIMDGRGVLASIVLGAEGVQMGTAFLTSQDSNASELLRDAIINSKETDTVITKAFSGKLARGINNRFIEEMSQYEGDIPDYPIQNELTSSIRKAAANIGDKELTHMWSGQSPRLATTHPANTIMSNIINQINQIMQYK
>NZ_LT992456.1|WP_000732338.1|435806_436628_-|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein
MKKLFGLILVLTFAVVLAACGNGSKSGSDDKKITVGASPAPHAEILEKAKPLLEKKGYELDIKTINDYTTPNKLLDKGEIDANYFQHTPYLNTEKKDKGYKIVSAGNVHLEPMAVYSKKYKSLKELPKGATVYVSNNPAEQGRFLKFFVDAGLIKIKKGVKIEDAKFSDITENKKDIKFNNKQSAEFLPKIYQNEDADAVIINSNFAIEQKLNPKKDSIAVESAKDNPYANLIAVKEGHQDDKKIKALIEVLQSKDIQDFINEKYNGAVIPAK
>NZ_LT992456.1|WP_000520237.1|436645_437341_-|ABC-transporter-permease
MGKSFSEIINEMITMPNIQWPEVWTAIVETLYMTVVSTIFTFILGLILGVLLFLSAKGKSIGARLFYSIVSFIVNLFRAIPFIILILLLIPFTSLILGTISGPTGALPALIIGAAPFYARLVEIAFKEIDKGVIEAAWSMGANTWTVIRKVLLPEAMPALVSGITVTAIALVGSTAVAGVIGAGGLGNLAYLTGFTRNQNDVILVSTVFILIIVFIIQFIGDWLTNKLDKR
>NZ_LT992456.1|WP_000571213.1|437333_438359_-|methionine-ABC-transporter-ATP-binding-protein
MIELKEVVKEYRTKNKEVLAVDHVNLSIRAGSIYGVIGFSGAGKSTLIRMFNHLEAPTSGEVIIDGDHIGQLSKNGLRAKRQKVSMIFQHFNLLWSRTVLKNIMFPLEIAGVPRRRAKQKALELVELVGLKGREKAYPSELSGGQKQRVGIARALANDPTVLLCDEATSALDPQTTDEILDLLLKIREQQNLTIVLITHEMHVIRRICDEVAVMESGKVIEHGPVTQVFENPQHTVTKRFVKEDLNDDFETSLTELEPLEKDAYIVRLVFAGSTTTEPIVSSLSTAYDIKINILEANIKNTKNGTVGFLVLHIPYISSVDFGKFEKELIERQVKMEVLRHG
>NZ_LT992456.1|WP_001065802.1|438608_438905_-|thioredoxin-family-protein
MNNSLDIKDVTTFYEEDKHLIFGYTPTCGTCKVSERMLDIANEILQLPLLKIDLNFYPQFCKDMQIMSTPILLLMNKDKEVKRIYAFQSVTDLLENLK
>NZ_LT992456.1|WP_001018957.1|438897_439284_-|hypothetical-protein
MAIVNKVIIVEGKSDKKRVQQVIAEPVNIICTHGTMSIDKFDDMIESLYDKQVFVLADSDDEGDRIRNWFKRYLSESEHIFIDKTYCQVANCPKQYLAHVLSKHGFTCKKETPFLPNINNERLVLVNE
>NZ_LT992456.1|WP_000932205.1|439985_440864_-|DUF1963-domain-containing-protein
MLNIQDVSHLSKKEQKAYNRFVESVENGNLPILPCIEMDLKEMQEETLNQSKIGGMPFLKSFKDIPLDENNVPMVLLAQINLDDLPEQQELFPVNEGILQFWISSEDQMYGMSENLKGNNINSRLVYIKEPISDLSLKDIQAHLKSLNADNEDIPFSGAFSIEFRLSKQTITCTDYKYDEDVLALWNKVNPSFALKSMFGGYDELMEPVCNTFTAKEPFNQLGGYPYFDQIDPRTNDQGLKMYDRVLLQIDSTRDGNSSIIWGDLGIANILVKSTDLEAMKFDDYMYSWDCS
>NZ_LT992456.1|WP_000290492.1|441043_441424_-|glycine-cleavage-system-protein-GcvH
MAVPNELKYSKEHEWVKVEGNVATIGITEYAQSELGDIVFVELPETDDEINEGDTFGSVESVKTVSELYAPISGKVVEVNEELEDSPEFVNESPYEKAWMVKVEVSDESQLEALLSAEKYAEMIGE
>NZ_LT992456.1|WP_000589549.1|441581_441938_-|arsenate-reductase-family-protein
MIKFYQYKNCTTCKKAAKFLDEYGVSYEPIDIVQHTPTINEFKTIIANTGVEINKLFNTHGAKYRELDLKNKLQTLSDDEKLELLSSDGMLVKRPLAVMGDKITLGFKEDQYKETWLA
>NZ_LT992456.1|WP_001147955.1|442081_442402_+|thioredoxin-family-protein
MQAIKSNESFKSVINSDTPVIVKFEAGWCPDCRAMDLWIDPIVEQYNDYQWYTVNRDELEDVVVENEVMGIPSLLVFKNGDKIAHLHSANAKSPEQVESFLAETFK
>NZ_LT992456.1|WP_000422911.1|442551_443091_-|nitroreductase
MELQQAIANRRSVKKFKRDMHIDDALLYQAIEKAADAPNHGMREPWRVVHVPKDRLGDMSKDISKFAFPNELDKQQCHYDAVTKLGGMLLLILKTDPRQRQNDENYFAFGAYAQNLMLLLYEVGIGTCWKSPLYIYDPKVRKTLGIKKDEVLAGFLYLTDLEEDMPKAPRKNRNLITLY

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Crispr_ID: NZ_LT992456_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LT992456_2

646681-646789

Orphan

Consensus_repeat	Method
TTTATGCAGTTGTGCGGTAGCATCCAACTGCGTTCCTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_LT992456_2

>merge|NZ_LT992456|2|646681-646789|CRISPRCasFinder
TTTATGCAGTTGTGCGGTAGCATCCAACTGCGTTCCTTTAAAGCCTCTTGAACTCTAGTGATTAGAGGCTTTTATGCAGTTGTGCGGTAGCATCCAACTGCGTTCCTTT

>NZ_LT992456|2|2|646681-646789|CRISPRCasFinder
TTTATGCAGTTGTGCGGTAGCATCCAACTGCGTTCCTTT	AAAGCCTCTTGAACTCTAGTGATTAGAGGCT
TTTATGCAGTTGTGCGGTAGCATCCAACTGCGTTCCTTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LT992456.1\|WP_000477504.1\|653821_654298_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_LT992456.1\|WP_000633790.1\|654467_655004_-\|flavodoxin-family-protein	unknown	unknown	gnl\|CDD\|223728
NZ_LT992456.1\|WP_016187113.1\|651937_652459_-\|YwhD-family-protein	unknown	unknown	gnl\|CDD\|378039
NZ_LT992456.1\|WP_010922824.1\|644640_645591_-\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NZ_LT992456.1\|WP_000901759.1\|646958_647594_-\|endonuclease-III-domain-containing-protein	unknown	unknown	gnl\|CDD\|225140
NZ_LT992456.1\|WP_021285860.1\|638102_639032_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|225778
NZ_LT992456.1\|WP_001018677.1\|639979_640354_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|130944
NZ_LT992456.1\|WP_000923047.1\|656657_657284_-\|DUF443-domain-containing-protein	unknown	unknown	gnl\|CDD\|335700
NZ_LT992456.1\|WP_000169038.1\|637685_637910_+\|DUF2922-domain-containing-protein	unknown	unknown	gnl\|CDD\|378571
NZ_LT992456.1\|WP_000749060.1\|645741_646629_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238563
NZ_LT992456.1\|WP_001045424.1\|640605_641394_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_LT992456.1\|WP_000365352.1\|643866_644586_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223943
NZ_LT992456.1\|WP_000808883.1\|655449_656388_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381309
NZ_LT992456.1\|WP_001021133.1\|648078_649740_-\|arginine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234964
NZ_LT992456.1\|WP_000735556.1\|642440_642947_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LT992456.1\|WP_001222139.1\|641562_642279_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LT992456.1\|WP_001200750.1\|650428_651439_-\|alcohol-dehydrogenase-AdhP	unknown	unknown	gnl\|CDD\|181842
NZ_LT992456.1\|WP_000180233.1\|652486_653782_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224004
NZ_LT992456.1\|WP_000362963.1\|643082_643883_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_LT992456.1\|WP_000359090.1\|649736_650153_-\|DUF1934-domain-containing-protein	unknown	unknown	gnl\|CDD\|226896

Protein	Function_ID	Function_description	E-value
NZ_LT992456.1\|WP_000633790.1\|654467_655004_-\|flavodoxin-family-protein	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	1.37974e-25
NZ_LT992456.1\|WP_016187113.1\|651937_652459_-\|YwhD-family-protein	gnl\|CDD\|378039	pfam08741, YwhD, YwhD family. This family of proteins are currently uncharacterized. They are around 170 amino acids in length.	5.69328e-97
NZ_LT992456.1\|WP_010922824.1\|644640_645591_-\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	6.43614e-48
NZ_LT992456.1\|WP_000901759.1\|646958_647594_-\|endonuclease-III-domain-containing-protein	gnl\|CDD\|225140	COG2231, COG2231, Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair].	5.92839e-91
NZ_LT992456.1\|WP_021285860.1\|638102_639032_+\|DMT-family-transporter	gnl\|CDD\|225778	COG3238, COG3238, Uncharacterized protein conserved in bacteria [Function unknown].	6.43292e-34
NZ_LT992456.1\|WP_001018677.1\|639979_640354_+\|transcriptional-regulator	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	1.77309e-26
NZ_LT992456.1\|WP_000923047.1\|656657_657284_-\|DUF443-domain-containing-protein	gnl\|CDD\|335700	pfam04276, DUF443, Protein of unknown function (DUF443). Family of uncharacterized proteins.	2.78629e-57
NZ_LT992456.1\|WP_001200750.1\|650428_651439_-\|alcohol-dehydrogenase-AdhP	gnl\|CDD\|181842	PRK09422, PRK09422, ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional.	0
NZ_LT992456.1\|WP_000749060.1\|645741_646629_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238563	cd01143, YvrC, Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains.	1.04955e-72
NZ_LT992456.1\|WP_001045424.1\|640605_641394_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.07146e-34
NZ_LT992456.1\|WP_000365352.1\|643866_644586_-\|HAD-family-hydrolase	gnl\|CDD\|223943	COG1011, COG1011, Predicted hydrolase (HAD superfamily) [General function prediction only].	5.71997e-38
NZ_LT992456.1\|WP_000359090.1\|649736_650153_-\|DUF1934-domain-containing-protein	gnl\|CDD\|226896	COG4506, COG4506, Uncharacterized protein conserved in bacteria [Function unknown].	6.10844e-58
NZ_LT992456.1\|WP_000808883.1\|655449_656388_-\|aldo/keto-reductase	gnl\|CDD\|381309	cd19083, AKR_AKR11A1_11D1, AKR11A and AKR11D families of aldo-keto reductase (AKR). Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).	1.23356e-168
NZ_LT992456.1\|WP_000169038.1\|637685_637910_+\|DUF2922-domain-containing-protein	gnl\|CDD\|378571	pfam11148, DUF2922, Protein of unknown function (DUF2922). This bacterial family of proteins has no known function.	3.83351e-14
NZ_LT992456.1\|WP_001021133.1\|648078_649740_-\|arginine--tRNA-ligase	gnl\|CDD\|234964	PRK01611, argS, arginyl-tRNA synthetase; Reviewed.	0
NZ_LT992456.1\|WP_000477504.1\|653821_654298_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.13315e-11
NZ_LT992456.1\|WP_000362963.1\|643082_643883_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.7852e-26
NZ_LT992456.1\|WP_000180233.1\|652486_653782_-\|HD-domain-containing-protein	gnl\|CDD\|224004	COG1078, COG1078, HD superfamily phosphohydrolases [General function prediction only].	3.99954e-151

>NZ_LT992456.1|WP_000749060.1|645741_646629_-|ABC-transporter-substrate-binding-protein
MKKSLIAFILIFMLVLSGCGMKDNDKQSSDDNGSSKSPYHRIVSLMPSNTEILYELGLGKYIVGVSTVDDYPKDVKKGKKQFDALNLNKEELLKAKPDLILAHESQKATANKVLSSLEKQGIKVVYVKDAQSIDETYNTFKQIGKLTHHDKQAEQLVEETKDNIDKVIDSIPAHHKKSKVFIEVSSKPEIYTAGKHTFFNDMLEKLEAQNVYSDINGWNPVTKESIIKKNPDILISTEAKTRSDYMDIIKKRGGFNKINAVKNTRIEVVNGDEVSRPGPRIDEGLKELRDAIYRK
>NZ_LT992456.1|WP_010922824.1|644640_645591_-|iron-ABC-transporter-permease
MTFNKVLLSWIVILIITTSIYLFWQLGDINDVFNQSILINVRLPRLLEALLTGMILTVAGLIFQTVLNNALADSFTLGLASGATFGSGLALFLGLTTLWIPVFSITFSLITLITVLVITSVLSQGYPVRILILSGLMIGALFNSLLYFLILLKPRKLNTIANYLFGGFGDAEYSNVSIIAITFIIALFGIFIILNQLKLLQLGELKSQSLGLNVQLITYIALCIASMITAINVAYVGIIGFIGMVIPQLIRKWQWKQSLGRQLALNIVIGGQIMVMADFIGSHILSPVQIPASIIIALIGIPVLFYMLISQSKRLH
>NZ_LT992456.1|WP_000365352.1|643866_644586_-|HAD-family-hydrolase
MDLNQIKAVVFDLEGTLLDRVKSREKFIEEQYERFHDYLIHVQLADFKKAFIELDDDEDNDKPDLYKEIIKRFHVDRLTWKDLFNDFEMHFYRYVFPYYDTLYTLEKLSQKGFQIGVIANGKSKIKQFRLHSLGLMHVINYLSTSETVGFRKPHPKIFEDMIDQLGVLPEQIMYVGDDALNDVAPARAMGMVSVWYKQEDAEIEPLEEEVDFTITTVEELLTILPIKIDNKGENYGSIY
>NZ_LT992456.1|WP_000362963.1|643082_643883_-|alpha/beta-hydrolase
MDLFTRKDGTSIHYSTLGEGYPIVLIHTVLDNYSVFNKLAAELAKSFQVVLIDLRGHGYSDKPRHIEIKDFSDDIVELLKYLYIEEVAFVCHEMGGIIGADISVRYPEFTSSLMLVNPTSIEGELPEERLFRKYAHIIRNWDPEKQDKFLNKRKYYRPRKMNRFLKHVVDTNEISTKEEIQAVKEVFKNADISQTYRNVVVPTKIIAGEFGERTTRLEAKEVADLIQNADFEVYQESSAFPFVEEQERFVEDTAAFINKHHDEKHV
>NZ_LT992456.1|WP_000735556.1|642440_642947_-|hypothetical-protein
MKKLLTASIIACSVVMGVGLANTSAEAASGNSIDTVKQLIKGDQSLENVKIGESIKDVLTKYKNPMYSYNENGTEHYYEFHTKKGMLLVTTDGKKNNGKVTHISMMYNDANGPTYQAVKNYVGKAVTHTEYSKVAGNFGYIEKGKTTYQFASAPKDKNIKLYRIDLEK
>NZ_LT992456.1|WP_001222139.1|641562_642279_-|hypothetical-protein
MRINDKILLENIEDYFNHKGLSPHLIDDIKEKVITDIKNSEKKDQDYIEYKRKSPAQIILMIQRNLFALQMNPVIFFILNFILISYLYDKQYVQFQAITGMSLFYCLVIFPMTIVVYLRVSQKNYLRSNKIEMIMGTIIAIISLLLIILQAFNITWGVIPITNFGHQFFFFIGIILVIAGIFYKRLEFSGIGLLFCQKTLDAMIHNPQSAQTFSLIIWILLVVLVIYFTIRLSSRTRL
>NZ_LT992456.1|WP_001045424.1|640605_641394_-|alpha/beta-hydrolase
MNKVTINPQIQLTYQIEGKGDPIILLHGLDGNLAGFEDLQHQLASSYKVLTYDLRGHGKSSKSESYDLNDHVEDLKILMEKLNIHEAHILGHDLGGVVAKLFTDKYAYRVKSLTTIASKKDDLIHSFTQLLIQYQDDIAGFNKSEAYILLFSKLFRNQEKTMKWYQKQRIYSIKSEDDSAVAIRSLILHKDEPMYLKKRTCVPTLLINGEHDPLIKDKNHFKLESHFLNVTKKIFEHSGHAPHIEEPEAFLSYYLNFLKSVS
>NZ_LT992456.1|WP_001018677.1|639979_640354_+|transcriptional-regulator
MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL
>NZ_LT992456.1|WP_021285860.1|638102_639032_+|DMT-family-transporter
MLLFYIIGVIVGMFIPIQTSVNSRLSLYTKSPFYTSFISFSVGTICLIVLNIFINPDVFSLHFFSNQTFNYTWFVGGLLGVGYLTGNLLLLPKLGATLTVIATVAGQIIMGVIIDTFGLFGATIHDFNLIKAIGVLLLIVGIITMNQINKCNILLTNQKHLIFWLLLGFTFGFFPPIQTTINSLLASHTHSPAFASLVSFTIGSITLLILTAIFNRSLKLKTSHLKFGKLKPIYFTGGILGMAFVTANIILMPHMGAALTTLIGMFGQILMGILIDHFGLFGSPKIAMTSRKTIGLLCILTGIILLRLF
>NZ_LT992456.1|WP_000169038.1|637685_637910_+|DUF2922-domain-containing-protein
MTKTLELSFKSSLDKPVKLQLPQLNNIVTEQVARDSMNALVDLNILKSNSGAITKVHSAQIIDKTTTVLFEAKK
>NZ_LT992456.1|WP_000901759.1|646958_647594_-|endonuclease-III-domain-containing-protein
MLGTDELYKLLYRHMGPQNWWPADNDIEMMLGAILVQNTRWRNAEIALNQIKEHTHFNPNHILELPIETLQSLIRPSGFYKSKSLTIKTLLTWLARHHFNYQEINERYKAELRKELLTLKGIGSETADVLLVYIFERIEFIPDSYTRKIYNKLGYENTKSYDQLKKVITLPNHFTNQDANEFHALLDVFGKHYFRDKDIKNYDFLEPYFKK
>NZ_LT992456.1|WP_001021133.1|648078_649740_-|arginine--tRNA-ligase
MNIIDQVKQTLVEEIAASINKAGLADEIPDIKIEVPKDTKNGDYATNIAMVLTKIAKRNPREIAQAIVDNLDTEKAHVKQIDIAGPGFINFYLDNQYLTAIIPEAIEKGDQFGHVNESKGQNILLEYVSANPTGDLHIGHARNAAVGDALANILTAAGYNVTREYYINDAGNQITNLARSIETRFFEALGDNSYSMPEDGYNGKDIIEIGKDLAEKHPEIKDYSEEARLKEFRKLGVEYEMAKLKNDLAEFNTHFDNWFSETSLYEKGEILEVLAKMKELGYTYEADGATWLRTTDFKDDKDRVLIKNDGTYTYFLPDIAYHFDKVKRGNDILIDLFGADHHGYINRLKASLETFGVDSNRLEIQIMQMVRLMENGKEVKMSKRTGNAITLREIMDEVGVDAARYFLTMRSPDSHFDFDMELAKEQSQDNPVYYAQYAHARICSILKQAKEQGIEVAAANDFTTITNEKAIELLKKVADFEPTIESAAEHRSAHRITNYIQDLASHFHKFYNAEKVLTDDIVKTKAHVAMIEAVRITLKNALAMVGVSAPESM
>NZ_LT992456.1|WP_000359090.1|649736_650153_-|DUF1934-domain-containing-protein
MDKKVSIYTKQVLKQHNEKEKFEFTTEGTWQQRQSNFIRYVEQIEDATVNVTIKVDDDSVKLIRKGDINMNLHFVEGQATTTFYDISAGRIPLEVKTLRILHFVSGDGGKLKIHYELYQDNEKMGSYQYEINYKEIGE
>NZ_LT992456.1|WP_001200750.1|650428_651439_-|alcohol-dehydrogenase-AdhP
MRAAVVTKDHKVSIEDKKLRALKPGEALVQTEYCGVCHTDLHVKNADFGDVTGVTLGHEGIGKVIEVAEDVESLKIGDRVSIAWMFESCGRCEYCTTGRETLCRSVKNAGYTVDGAMAEQVIVTADYAVKVPEKLDPAAASSITCAGVTTYKAVKVSNVKPGQWLGVFGIGGLGNLALQYAKNVMGAKIVAFDINDDKLAFAKELGADVIINSKDVDPVAEVMKLTDNKGLDATVVTSVAKTPFNQAVDVVKAGARVVAVGLPVDKMNLDIPRLVLDGIEVVGSLVGTRQDLREAFEFAAENKVTPKVQLRKLEEINDIFEEMENGTITGRMVIKF
>NZ_LT992456.1|WP_016187113.1|651937_652459_-|YwhD-family-protein
MEVISLSEKKGFNFNIIKNDPLDGHKGTNIGSISLDNIAPVFIDVANKEAFIDIGGMHARAKVEKGVKWITDKAAVEGDEAKEYWLCWVTTERNEQGPYYAGLTACYLLVNKAIRRGYKSMPEHVNMMDKSMKHHIIIDQIGDENKVILKDFLMNHDEGMWKHSSDALHQAFN
>NZ_LT992456.1|WP_000180233.1|652486_653782_-|HD-domain-containing-protein
MTNAYVDLKLVEEKVFKDPIHRYIHVEDQLIWDLIKTKEFQRLRRIRQLGTLYLSFHTAEHSRFGHSLGVYEIVRRLIDESFIGHDAWDNKDRPLALCAALLHDLGHGPFSHSFEKIFNTDHEAYTQAIITGDTEVNAVLRKVSPEFPREVAEVINKTHHNKLVISMISSQIDADRMDYLQRDAYFTGVSYGAFDMERILRLMRPSKDEVLIKESGMHAVENFIMSRYQMYWQIYFHPVSRGGEVLLNNCLKRAKQLYNEGYEFKLHPHDFIPFFEETVTIEQYVELDEAVVTYYLEKWTKEDDAILSDLASRFINRDLFKYIPFDGSIITISELQELFEAGGINPDYYFVSEAFSDLPYDYDRPGSNRKPIHLLRQDGKIREISNQSLVIHSITGINRQDYKLYYPREMVAKIKDKTIREAIENLINELN
>NZ_LT992456.1|WP_000477504.1|653821_654298_-|GNAT-family-N-acetyltransferase
MFKVRQATEKDVVQIRDVATKAWFNTYLNIYAATTVNHLLEASYNEHHLKKRLQEQLFLVVEEGNDIVGFANFIYGEELYLSAHYVKPESQHTGYGTALLNEGLSRFEDKFEGVYLEVDNKNEEAVAYYKEQGFTILRSYEPEMYGEKLDLALMYKAF
>NZ_LT992456.1|WP_000633790.1|654467_655004_-|flavodoxin-family-protein
MITVLFGGSRPNGNTAQLTKFALQGLDYQWIDVTQHRFKPIRDVRHIEESITDYEDDYQEILDKVLASDTIIFASPVYWYSISAPLKAFIEHWSETLQDKRYPNFKAQMAEKDFRVILVGGDCPKIKAKPAITQMKYSLDFLGATLNGYIIGTANKPGDIMKDNYALARATEWNQLLQ
>NZ_LT992456.1|WP_000808883.1|655449_656388_-|aldo/keto-reductase
MKQFVNLGKSDVEVFPIALGTNAVGGHNLYPNLDEEQGKDVVRQAINHGINFLDTAYIYGPERSEELVGEVVKEYPREQIKIATKGSHEFDENQEVHQNNQPEYLKQQVENSLKRLQTDYIDLYYIHFPDDNTPKDQAVAALQELKEQGKIKAIGVSNFTLDQLKEANKDGYVDVVQLEYNLLHRENEAVLQYCVDHQITFIPYFPLASGILAGKYDENTKFSDHRTTRRDFKPGVFEENVRRVNALEKIAAAHQTSIANIVLAFYLTRPAIDVIIPGAKRAEQVIENIKAADIVLSKDEIQYIDELFPIED
>NZ_LT992456.1|WP_000923047.1|656657_657284_-|DUF443-domain-containing-protein
MLLCESKIINKNPKYRIIKYNDEYLMVDIISTWISLFFPFINWFIPKRYVKISKEDFENLNIVKPAKKNVFWPVAGISALFAVTLRKYTHLLDTQLDKKLVIAICCITFIGILIFYVRLIKKSSLNIYNPKNERSKIILIPTLKNFCFTLFGYILFGGLTMLFLDALLSMSHQNIIVYFTWIAVIMGFFLVNIALIIDKNIYVILKNQ

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Crispr_ID: NZ_LT992456_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LT992456_3

1559215-1559348

Orphan

Consensus_repeat	Method
TATTGAAGAAGATACAA	PILER-CR

2 spacers

The CRISPR arrays of NZ_LT992456_3

>merge|NZ_LT992456|3|1559215-1559348|PILER-CR
TATTGAAGAAGATACAAACAAAGACAAACCTAATTATCAATTTGGTGGACACAACAGTGTTGATTTTGAAGAAGATACACTTCCAAAAGTAAGTGGTCAAAATGAAGGTCAACAAACGATTGAAGAAGATACAA

>NZ_LT992456|3|1|1559215-1559348|PILER-CR
TATTGAAGAAGATACAA	ACAAAGACAAACCTAATTATCAATTTGGTGGACACAACAGTGTTGA
TTTTGAAGAAGATACAC	TTCCAAAAGTAAGTGGTCAAAATGAAGGTCAACAAAC
GATTGAAGAAGATACAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LT992456.1\|WP_000274558.1\|1552523_1553201_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_LT992456.1\|WP_001117057.1\|1550098_1550515_+\|DUF2188-domain-containing-protein	unknown	unknown	gnl\|CDD\|227213
NZ_LT992456.1\|WP_000581897.1\|1570657_1571422_+\|tandem-type-lipoprotein	unknown	unknown	gnl\|CDD\|367972
NZ_LT992456.1\|WP_014937076.1\|1571669_1572455_+\|tandem-type-lipoprotein	unknown	unknown	gnl\|CDD\|367972
NZ_LT992456.1\|WP_000167480.1\|1543528_1544692_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341027
NZ_LT992456.1\|WP_000074000.1\|1551602_1552367_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133381
NZ_LT992456.1\|WP_016187290.1\|1568600_1569530_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370247
NZ_LT992456.1\|WP_000435037.1\|1544789_1545401_-\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NZ_LT992456.1\|WP_000217726.1\|1564482_1564791_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LT992456.1\|WP_000721337.1\|1563490_1564357_+\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	unknown	unknown	gnl\|CDD\|224131
NZ_LT992456.1\|WP_000660709.1\|1545947_1547225_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340877
NZ_LT992456.1\|WP_031774865.1\|1569772_1570546_+\|tandem-type-lipoprotein	unknown	unknown	gnl\|CDD\|367972
NZ_LT992456.1\|WP_000083859.1\|1572451_1573807_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238287
NZ_LT992456.1\|WP_000481425.1\|1554895_1556254_+\|gluconate-permease	unknown	unknown	gnl\|CDD\|129873
NZ_LT992456.1\|WP_000678764.1\|1564934_1565201_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LT992456.1\|WP_000586373.1\|1548136_1549960_+\|FUSC-family-protein	unknown	unknown	gnl\|CDD\|224208
NZ_LT992456.1\|WP_000282632.1\|1567311_1568505_-\|DNA-(cytosine-5-)-methyltransferase	unknown	unknown	gnl\|CDD\|273211
NZ_LT992456.1\|WP_000876645.1\|1553225_1554779_+\|gluconokinase	unknown	unknown	gnl\|CDD\|130381
NZ_LT992456.1\|WP_014653252.1\|1565484_1567236_-\|phospho-sugar-mutase	unknown	unknown	gnl\|CDD\|100092
NZ_LT992456.1\|WP_000289136.1\|1550745_1551438_+\|GTP-pyrophosphokinase-family-protein	unknown	unknown	gnl\|CDD\|225232

Protein	Function_ID	Function_description	E-value
NZ_LT992456.1\|WP_000274558.1\|1552523_1553201_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	7.62004e-44
NZ_LT992456.1\|WP_001117057.1\|1550098_1550515_+\|DUF2188-domain-containing-protein	gnl\|CDD\|227213	COG4876, COG4876, Uncharacterized protein conserved in bacteria [Function unknown].	1.54722e-61
NZ_LT992456.1\|WP_000581897.1\|1570657_1571422_+\|tandem-type-lipoprotein	gnl\|CDD\|367972	pfam04507, DUF576, Csa1 family. This family contains several uncharacterized staphylococcal proteins. These proteins have been called conserved staphylococcal antigens (Csa).	2.21828e-125
NZ_LT992456.1\|WP_000167480.1\|1543528_1544692_+\|MFS-transporter	gnl\|CDD\|341027	cd17474, MFS_YfmO_like, Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily. This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.37674e-71
NZ_LT992456.1\|WP_000074000.1\|1551602_1552367_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	3.96069e-33
NZ_LT992456.1\|WP_016187290.1\|1568600_1569530_+\|hypothetical-protein	gnl\|CDD\|370247	pfam09019, EcoRII-C, EcoRII C terminal. The C-terminal catalytic domain of the Restriction Endonuclease EcoRII has a restriction endonuclease-like fold with a central five-stranded mixed beta-sheet surrounded on both sides by alpha-helices. It cleaves DNA specifically at single 5' CCWGG sites.	6.01914e-12
NZ_LT992456.1\|WP_000435037.1\|1544789_1545401_-\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	7.11271e-43
NZ_LT992456.1\|WP_014937076.1\|1571669_1572455_+\|tandem-type-lipoprotein	gnl\|CDD\|367972	pfam04507, DUF576, Csa1 family. This family contains several uncharacterized staphylococcal proteins. These proteins have been called conserved staphylococcal antigens (Csa).	2.08363e-133
NZ_LT992456.1\|WP_000721337.1\|1563490_1564357_+\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	gnl\|CDD\|224131	COG1210, GalU, UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane].	5.5142e-177
NZ_LT992456.1\|WP_000660709.1\|1545947_1547225_+\|MFS-transporter	gnl\|CDD\|340877	cd17319, MFS_ExuT_GudP_like, Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily. This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.24287e-91
NZ_LT992456.1\|WP_031774865.1\|1569772_1570546_+\|tandem-type-lipoprotein	gnl\|CDD\|367972	pfam04507, DUF576, Csa1 family. This family contains several uncharacterized staphylococcal proteins. These proteins have been called conserved staphylococcal antigens (Csa).	3.80143e-129
NZ_LT992456.1\|WP_000083859.1\|1572451_1573807_+\|hypothetical-protein	gnl\|CDD\|238287	cd00519, Lipase_3, Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of becoming active at the lipid/water interface, although several examples of lipases have been identified that do not undergo interfacial activation . The active site of a lipase contains a catalytic triad consisting of Ser - His - Asp/Glu, but unlike most serine proteases, the active site is buried inside the structure. A "lid" or "flap" covers the active site, making it inaccessible to solvent and substrates. The lid opens during the process of interfacial activation, allowing the lipid substrate access to the active site. .	0.00130687
NZ_LT992456.1\|WP_000481425.1\|1554895_1556254_+\|gluconate-permease	gnl\|CDD\|129873	TIGR00791, Gluconate_permease, gluconate transporter. This family includes known gluconate transporters of E. coli and Bacillus species as well as an idonate transporter from E. coli. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	2.53789e-168
NZ_LT992456.1\|WP_000586373.1\|1548136_1549960_+\|FUSC-family-protein	gnl\|CDD\|224208	COG1289, COG1289, Predicted membrane protein [Function unknown].	1.43413e-83
NZ_LT992456.1\|WP_000282632.1\|1567311_1568505_-\|DNA-(cytosine-5-)-methyltransferase	gnl\|CDD\|273211	TIGR00675, Modification_methylase, DNA-methyltransferase (dcm). All proteins in this family for which functions are known are DNA-cytosine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair].	1.26934e-125
NZ_LT992456.1\|WP_000876645.1\|1553225_1554779_+\|gluconokinase	gnl\|CDD\|130381	TIGR01314, gntK_FGGY, gluconate kinase, FGGY type. Gluconate is derived from glucose in two steps. This model describes one form of gluconate kinase, belonging to the FGGY family of carbohydrate kinases. Gluconate kinase phosphoryates gluconate for entry into the Entner-Douderoff pathway. [Energy metabolism, Sugars].	0
NZ_LT992456.1\|WP_014653252.1\|1565484_1567236_-\|phospho-sugar-mutase	gnl\|CDD\|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NZ_LT992456.1\|WP_000289136.1\|1550745_1551438_+\|GTP-pyrophosphokinase-family-protein	gnl\|CDD\|225232	COG2357, COG2357, PpGpp synthetase catalytic domain [General function prediction only].	8.50652e-86

>NZ_LT992456.1|WP_000481425.1|1554895_1556254_+|gluconate-permease
MFNEIWPLISVVLGIVILLVLIIGFKLNTFISLIITSMITALMLGIPLTKIMETIEKGMGSTLGHIALIFGLGAILGKLLADGGGATRIADTLIQKFGQKHVQWAMLVAAFIVGIALFFEVGLVLLIPLVFTVAKRANVSVLKLGLPMVTALSVTHGFLPPHPGPVVIAKELKANVGDVLLYGMIIAIPVTLIAGPIFNKVAQKMIPSAYTREGDISALGAQKEFTDQEMPGFGMSLLTATLPVILMLVSTITQLVTGHDKPTNLFESIIYMIGTAGTAMLIAVLFAIVTMGLMRKRKMNHIMESVTNAIYPIGMMLLIIGGGGTFKQVLIDGGVGNTIAKMFEGTEMSPILLAWIVAAVLRIALGSATVAAISTTGIVLPLLQSSDVNVALVVLAIGAGSVILSHVNDAGFWMFKEYFGLTVKETFLTWSLLETIISVSGIIFILFISLFV
>NZ_LT992456.1|WP_000876645.1|1553225_1554779_+|gluconokinase
MKYMIGVDIGTTSTKSVLYDENGTFIMKHQIGYDLHTPNVDVSEENPDELFDAVLMTIKYIMRESKVNQDDIKFVSFSAQMHSLIAMDQQHQRLTNNITWADNRAAKYATVINEVHDGNAIYQRTGTPIHPMSPLAKIFWMKHEWQDVFQRTAKFADIKTYIFYHLFDRYIIDYSMASATGMFNLETLDWDVGALELLGISEEMLPELVPTTYVMKGMKERYATLMGLNEDTPFVIGASDGVLSNLGVNSVGKGEVAVTIGTSGAIRTVIDKPRTDYKGRIFCYVLTEDHYVIGGPVNNGGVVLRWLRDELLASEVETAKRLGVDPYDVLTQIAKRVKPGADGLIFHPYLAGERAPLWNANARGSFFGLTLSHKKEHMIRAALEGVLYNLYTVYLALIEVMNETPKMIKATGGFAKSEVWRQMMSDIFDTELVVPESYESSCLGACVLGLKAVGDIEDFSIVSSMVGATNNHTPIEENVAVYQELESIFINLSRSLTENYEQISDFQRQHMAENKTQ
>NZ_LT992456.1|WP_000274558.1|1552523_1553201_+|GntR-family-transcriptional-regulator
MYGYPEKWLEGMTTGEGIAAELRLGIVNGHIAEGTLLTENQMAKQFNVSRSPIRDAFKLLQQNQLIQLERMGAHVLPFGEQEKKEMYDLRLMLESFAFSRVKNQERLPIVKEMKKQLEMMKVAVKFEDAESFTKHDFEFHETLIKASNHQYLNSFWSHLKPVMMALVLTSMRQRMQQNPQDFERIHHNHQVFIDAVEQYDSQILKEAFHLNFDDVGKDIEGFWLN
>NZ_LT992456.1|WP_000074000.1|1551602_1552367_+|MerR-family-transcriptional-regulator
MSNYSTGELAKLCNVTTRTIQYYDRKGILKPQGFTEGKRRVYTEQQRQTLELILLLKDLGCALSDIDMLLKGEGTLKTLNTLLTMKQQEINQQVKQQQAVLDKIKNVQYYVNEASTSPITHLKDIEHVMSKSAEMKSIRRNIWISAGIIGIIQYSSIISAILMKNKWPFLIALPFMISYGIGITIYYQRKVAYLCPNCQHIFSPSLWAVIKAKHTATTRRFECPNCHETHYCIEVPKTHMSTEQLEVPRTKNNN
>NZ_LT992456.1|WP_000289136.1|1550745_1551438_+|GTP-pyrophosphokinase-family-protein
MYVDRKPSLYLEDLRHDFKNSLSKFENGDEAFDTLLGFVELDHIYSSALKEISTKLSILDDNFNHIYKHNPIHHMERRVKEMRSLIEKLNRKGLQISAETAKEHILDIAGIRVVCNYLDDIYLIEEMLLKQEDVQLIKRKDYIQHPKENGYRSLHIVVSIPVFLAERVEVLPVEIQIRTIGMDMWASLEHKIRYKNNAETEKYRDLLKECATEITEVEDKLQQIHSEITE
>NZ_LT992456.1|WP_001117057.1|1550098_1550515_+|DUF2188-domain-containing-protein
MPFTMKGYPEKWKEFEVIKRQKAIEIANAMLKEGYLEKDVVPIAAKKAKDWYRALSKEEIKALEEENFVQFHTATMEKTEVDSEYATTDNEEHIQEQSNQDKSYFDSESIVNQSGGVRQREPLMDGPHPKVVESFKDV
>NZ_LT992456.1|WP_000586373.1|1548136_1549960_+|FUSC-family-protein
MIIPAIIGYLCGNFQFGLLVATGTLAHIYVFKGPSRSKLRTVIICNLAFAICMILGTLTATTPLVFGMTLLIVTVIPFYIFTALKIAGPSSTFFIVTFSLPINLPIAPEEALYRGFAILVGGVLATMMVLITILLSKNKAEEQAIQNDFKLISKLLHAYNDKSAFSQVAKTAVDSFKASDKLLITSNSSSDKLSGRFQKLLLLHTSAQGIYSELLELNAKQIRPLPDELIEMMDHIITQRDDRNKNVRYWRKEVTVTEEFQNLFNHILKIDEMVHANEARIAYEAEMRKPLYSKRIYQNLTLDSIVFRNTLRYAAIMMIAIFIALMFDFEKAYWIPLSAHTVLLGTSTIHAIERGIARGLGTILGVLVLSVILLFSIPTPVAVILMGIAALFTEALVGANYTIAVVFITIQVILMNGLASQNLTINIAFPRVIDVAMGIVIAIIGLFVLGQRTASALLPYVMAEVVRKEATLFHYLFSENQYKDDVYQKNTAMNLSVKLNNMTQVYNAANGELFSDKTLIQNYYPSLFALEEISFMLNRAMANEDRLTINEQLMGEYLATFENIAKHLELNTELEIKILPDLPQYNYIQSAMMNIQHNGFRERDKNV
>NZ_LT992456.1|WP_000660709.1|1545947_1547225_+|MFS-transporter
MKEKRTNVRWMFALAFFFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVLWAIIAKDLPEQHRMVNEAEKRFIMENRDIVATEKSSPPWNDFFKRFSFYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKEMSISSLPWLLMFFLILSAGAISDRVLGLGRSKFVARGVIAIAGFIVFAVSIIFAVRTGNLYVSIFWLSLGLGGIGISMGMSWAAATDLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVPAVIAVIMWFYVKPDQPLIVSDDKAIEK
>NZ_LT992456.1|WP_000435037.1|1544789_1545401_-|DedA-family-protein
MEQIITEFISRFGYAAIFILILLENILPIVPSEIILTFAGLMSVKSHLSILTLFIIATIASFIGLLILYYICRLISEERLYRFIDRHGKWIKLKSKDLKRANDWFKKYGVWAVFICRFIPVLRVLITIPAGVNRMNVVTFTVISLIGTTIWNFGLILLGRTLSDSFGMLMTGLHTYSRIMYVVIIIAVIYFAIRYIGKRKRVK
>NZ_LT992456.1|WP_000167480.1|1543528_1544692_+|MFS-transporter
MTKSNIRLYILGFLAFFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAVTHNFILFAISRLFQAIGCGIIPLVTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLLVISIVLFLIIFFIDIPNVEKGIVKLTEKIEEKYLTDKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGISGVLFLPITVSVILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLFGWLNESNVIILSVIIFILGTCVGIVPALLATIISKRFEHIKGKVLGVFNFVRYIGMTVGALLIGIISQPLVAFYFTTITIMLIIIFLYIKIGDFQLKYAK
>NZ_LT992456.1|WP_000721337.1|1563490_1564357_+|UTP--glucose-1-phosphate-uridylyltransferase-GalU
MKKIKKAIIPAAGLGTRFLPATKAMPKEMLPILDKPTIQYIVEEAARAGIEDIIIVTGRHKRAIEDHFDSQKELEMVLKEKGKSELLEKVQYSTELANIFYVRQKEQKGLGHAISSARQFIGNEPFAVLLGDDIVESEVPAVKQLIDVYEETGHSVIGVQEVPEADTHRYGIIDPLTKNGRQYEVKKFVEKPAQGTAPSNLAIMGRYVLTPEIFDYLKTQKEGAGNEIQLTDAIERMNNDNQVYAYDFEGERYDVGEKLGFVKTTIEYALKDDSMREELTRFIKELGL
>NZ_LT992456.1|WP_000217726.1|1564482_1564791_-|hypothetical-protein
MTVNIVVSIVFCISMVVLSIYVAITKDFTLISYINQTTIADKHKNQIAYIFALCISLSAVFLMSAILCFEYDFIALAFLFLTIALLLIALFYVCFYKITKYP
>NZ_LT992456.1|WP_000678764.1|1564934_1565201_-|hypothetical-protein
MKGSKQILLIMGIISLIVLFIFTLFIMAQYAKHYEQKSDSSNAHTLNSSSAIIEQHTMSNLASLDLYAPVRNITSSRDIHPIYFMTKD
>NZ_LT992456.1|WP_014653252.1|1565484_1567236_-|phospho-sugar-mutase
MFFYFWGVFLYNSLHKCKGFSFHVLLSLTEILKGCLATMDKELWIERANDSLVKHFYEQQSDIEQREGFESKLTFGTAGIRGKFGLGEGRLNKFTIEKLALGLSRYLNAQTNNPTIVIHYDIRHLSTEFAQIIANVLANHQITVYLPDTYKTTPELSFAVRNLNTTAGIMITASHNPKDYNGIKVYGSDGAQLSTDASELVSRYIEDVGDPLQIDISFSKHNSSYIKPLPKSVAENYIKHIQNMIGYIPKSDLQVVFTSLHGTSVPIVPELLKSLNFNQFNLVEAQCKPDPNFSSVQSANPEDHRAFDQAVELANKSHADLLISTDPDADRLGIAERDAHGHITYFNGNQIGALLLNYRIQQTSQLRHRLMIQSIVSSELTKSLARYNNVEYKEVLTGFKFIAQEIRQLDDHQNMIFAFEESYGFLSEPFVRDKDAVQIVPLIIKYASELKLYGKTLKDELEQIYQTVGRHEDTLFSHTLEGLEGKKKIESIMTHFRSHPPQEIQGLKVKAIEDYLTSEVHQLDKDTTSQINSPKSNVIRVLFDEGFIALRPSGTEPKIKLYVSLKCPNFDDVAQKINAMIFS
>NZ_LT992456.1|WP_000282632.1|1567311_1568505_-|DNA-(cytosine-5-)-methyltransferase
MYNNIITKNESDNSIPLNYGDFIKEKRNKLNMTQKELADSIGLPKFGDRTIRRWENYETSPSYLEYKTIMNFPDTPPYLNPNIYDYKMIDLFAGIGGTRLGFQLHGNVKCVFSSEWDKFSAKTYKANFGETPKGDITQIIADEIPTHDILVAGFPCQAFSQAGLKKGFNDTRGTLFFDIARILKAKRPKCFLLENVKNLRSHDKGKTFDIIMNTLLELDYDVSSSILRARDFGCPQNRERIYIVGFDKQQIKNAENFSFPEPLPIETSLGSILESNVNDKYTISDRLWYGHQRRKREHKAKGNGFGYSIFNETSPYTNTLSARYYKDGSEILIEQNKKNPRKLTPREAARLQGFPENYIIPVSDTQAYKQFGNSVSVPVVHAIASNIFQVLQQNKNN
>NZ_LT992456.1|WP_016187290.1|1568600_1569530_+|hypothetical-protein
MTNLNNQLKEFKNTIKVERSKLLPSPFDMVYKNFEKLGYHKQNEQFFYDNASIIIDELRNQSWIEFKKIEKEFSKKLYSHLLDQDSENYKNMTVKEGIEKFTSKHTDEIYALQLSNTQSRRSRAGKEFESIIELVLMGANIEFVTQGSIGSGVFESSELAKLVDCVVPGAAEYNLNKRNTSLISTKTSLRERWQEVGDEMSRTKAKEMYLVTLDESISEKTLKLIEKNNIIIVTTKSVIDKNYLNSSNVISFEDMLNELHIQLLQWNNYGYPATELNNKKELYQTLIEKYDGNMFVRNYYENMLSNINV
>NZ_LT992456.1|WP_031774865.1|1569772_1570546_+|tandem-type-lipoprotein
MIHSRKLRLCLYLVLLAVFIGACGMKKEESSKDKQIKENFTKTLNLYPTKNLEDFYDKEGFRDQEFEKGDKGTWIVDSEMVIELKDKKMESRSMVLYINRNTRTTKGNFIVRELWEDSKGYAQSKDTKYPVKMEHNKIIPTKPIADDKLRKEIENFKFFVQYGDFKDINDYKDGDISYNSNVPSYSAKYQLSNDDYNVKQLRKRYDIPTKKAPKLLIKGDGDLKGSSIAHKNLEFTFIENKEENIYFTDSINFKPTE
>NZ_LT992456.1|WP_000581897.1|1570657_1571422_+|tandem-type-lipoprotein
MIHSKKLTLGICLVLLIILIVGYVIMTKTNGRNAQIKEAFNKTLNVYPTKNLEDFYDKEGFRDQEFDKRDKGTWIINSGMNIQLKGGALKSRAMVLYINRNTRTAKGYFLISETTEDKKGYVHNKDKKYPVKMEHNQIIPTKPIRDDKLKKEIENFKFFVQYGDFKDYKDGDISYNPNVPSYSANYQLNNDDYNVQQLRKRYDISTKRAPELKLRGSGDLKGSSVGSKELEFNFIRNKEENVYFTDSINFKPTE
>NZ_LT992456.1|WP_014937076.1|1571669_1572455_+|tandem-type-lipoprotein
MIHSKKLKLCLCLIILSVFIGGCGMKKEESSKDKQIKENFNKTLSLYPTKNLEDFYDKEGFRDEEFEKGDKGTWIIHSKMIIETNGRNMESRGMVLYINRNTRTTKGNFVIREITEDSKGYSDSKDKKYPVKMENNRIVPMKPIHDEKLRKEIEDFKFFVQYGNFKDINDYKDGDISYNPNVPSYSAKYQLSNDDYNVKQLRKRYDIPTKKAPKLLLKGDGDLKGSSVGSKNLEFTFVENKEENIYFTDSVQYTPSEDNNL
>NZ_LT992456.1|WP_000083859.1|1572451_1573807_+|hypothetical-protein
MSQTEYQIKPGNIKANSEETSTVSKISYEIENANNSGLKKGKINEQIEGLKEEGKFPKNLKYLKSYTDPNTGTTTTAFKNKDTGKVTLGMTGTNLHFEEMGNVLKHPFNHSDQDMKDMKEMLKDFGADANIGLGAVTDKDPHFKDTQDFIKDIKKEYEIDTITGHSLGGRDAIILGVSNDIKNIVVYNPAPLSITDFRIIALNNMTYSAIGDIEIKEMLKNYNGHIVRFVSDKDELDGFVSQFMYDTAGEKIVLNNGEGHDMGAFLRKYAQAKILAELRKVKGYEDANNKSFKSVKDNTKSKLGKVEELRVNWLQANGGALTSSQLKLLESVSALIIAEGLSQLVKEESNQLEKMYDNMKDKFQENWKNSQEAGNKIGTKLSHDGVLTALRNGDAYESKFETEPLTKIEQKLKELNDINSDCHNYVSKIKDSVNAIVGNDQLLASQIAGVI

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Crispr_ID: NZ_LT992456_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LT992456_4

1562759-1562892

Orphan

Consensus_repeat	Method
TATTGAAGAAGATACAA	PILER-CR

2 spacers

The CRISPR arrays of NZ_LT992456_4

>merge|NZ_LT992456|4|1562759-1562892|PILER-CR
TATTGAAGAAGATACAAACAAAGATAAACCTAATTATCAATTTGGTGGACACAACAGTGTTGATTTTGAAGAAGATACACTTCCAAAAGTAAGTGGTCAAAATGAAGGTCAACAAACGATTGAAGAAGATACAA

>NZ_LT992456|4|2|1562759-1562892|PILER-CR
TATTGAAGAAGATACAA	ACAAAGATAAACCTAATTATCAATTTGGTGGACACAACAGTGTTGA
TTTTGAAGAAGATACAC	TTCCAAAAGTAAGTGGTCAAAATGAAGGTCAACAAAC
GATTGAAGAAGATACAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LT992456.1\|WP_000274558.1\|1552523_1553201_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_LT992456.1\|WP_001117057.1\|1550098_1550515_+\|DUF2188-domain-containing-protein	unknown	unknown	gnl\|CDD\|227213
NZ_LT992456.1\|WP_000581897.1\|1570657_1571422_+\|tandem-type-lipoprotein	unknown	unknown	gnl\|CDD\|367972
NZ_LT992456.1\|WP_014937076.1\|1571669_1572455_+\|tandem-type-lipoprotein	unknown	unknown	gnl\|CDD\|367972
NZ_LT992456.1\|WP_000794645.1\|1556722_1559776_+\|fibronectin-binding-protein-FnbA	unknown	unknown	gnl\|CDD\|371043
NZ_LT992456.1\|WP_000074000.1\|1551602_1552367_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133381
NZ_LT992456.1\|WP_016187290.1\|1568600_1569530_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370247
NZ_LT992456.1\|WP_000435037.1\|1544789_1545401_-\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NZ_LT992456.1\|WP_000217726.1\|1564482_1564791_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LT992456.1\|WP_000721337.1\|1563490_1564357_+\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	unknown	unknown	gnl\|CDD\|224131
NZ_LT992456.1\|WP_000660709.1\|1545947_1547225_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340877
NZ_LT992456.1\|WP_031774865.1\|1569772_1570546_+\|tandem-type-lipoprotein	unknown	unknown	gnl\|CDD\|367972
NZ_LT992456.1\|WP_000083859.1\|1572451_1573807_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238287
NZ_LT992456.1\|WP_000481425.1\|1554895_1556254_+\|gluconate-permease	unknown	unknown	gnl\|CDD\|129873
NZ_LT992456.1\|WP_000678764.1\|1564934_1565201_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LT992456.1\|WP_000586373.1\|1548136_1549960_+\|FUSC-family-protein	unknown	unknown	gnl\|CDD\|224208
NZ_LT992456.1\|WP_000282632.1\|1567311_1568505_-\|DNA-(cytosine-5-)-methyltransferase	unknown	unknown	gnl\|CDD\|273211
NZ_LT992456.1\|WP_000876645.1\|1553225_1554779_+\|gluconokinase	unknown	unknown	gnl\|CDD\|130381
NZ_LT992456.1\|WP_014653252.1\|1565484_1567236_-\|phospho-sugar-mutase	unknown	unknown	gnl\|CDD\|100092
NZ_LT992456.1\|WP_000289136.1\|1550745_1551438_+\|GTP-pyrophosphokinase-family-protein	unknown	unknown	gnl\|CDD\|225232

Protein	Function_ID	Function_description	E-value
NZ_LT992456.1\|WP_000274558.1\|1552523_1553201_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	7.62004e-44
NZ_LT992456.1\|WP_001117057.1\|1550098_1550515_+\|DUF2188-domain-containing-protein	gnl\|CDD\|227213	COG4876, COG4876, Uncharacterized protein conserved in bacteria [Function unknown].	1.54722e-61
NZ_LT992456.1\|WP_000581897.1\|1570657_1571422_+\|tandem-type-lipoprotein	gnl\|CDD\|367972	pfam04507, DUF576, Csa1 family. This family contains several uncharacterized staphylococcal proteins. These proteins have been called conserved staphylococcal antigens (Csa).	2.21828e-125
NZ_LT992456.1\|WP_000794645.1\|1556722_1559776_+\|fibronectin-binding-protein-FnbA	gnl\|CDD\|371043	pfam10425, SdrG_C_C, C-terminus of bacterial fibrinogen-binding adhesin. This is the C-terminal half of a bacterial fibrinogen-binding adhesin SdrG. SdrG is a Gram-positive cell-wall-anchored adhesin that allows attachment of the bacterium to host tissues via specific binding to the beta-chain of human fibrinogen (Fg). SdrG binds to its ligand with a dynamic "dock, lock, and latch" mechanism which represents a general mode of ligand-binding for structurally related cell wall-anchored proteins in most Gram-positive bacteria. The C-terminal part of SdrG(276-596) is integral to the folding of the immunoglobulin-like whole to create the docking grooves necessary for Fg binding. The domain is associated with families of Cna_B, pfam05738.	1.05517e-24
NZ_LT992456.1\|WP_000074000.1\|1551602_1552367_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	3.96069e-33
NZ_LT992456.1\|WP_016187290.1\|1568600_1569530_+\|hypothetical-protein	gnl\|CDD\|370247	pfam09019, EcoRII-C, EcoRII C terminal. The C-terminal catalytic domain of the Restriction Endonuclease EcoRII has a restriction endonuclease-like fold with a central five-stranded mixed beta-sheet surrounded on both sides by alpha-helices. It cleaves DNA specifically at single 5' CCWGG sites.	6.01914e-12
NZ_LT992456.1\|WP_000435037.1\|1544789_1545401_-\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	7.11271e-43
NZ_LT992456.1\|WP_014937076.1\|1571669_1572455_+\|tandem-type-lipoprotein	gnl\|CDD\|367972	pfam04507, DUF576, Csa1 family. This family contains several uncharacterized staphylococcal proteins. These proteins have been called conserved staphylococcal antigens (Csa).	2.08363e-133
NZ_LT992456.1\|WP_000721337.1\|1563490_1564357_+\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	gnl\|CDD\|224131	COG1210, GalU, UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane].	5.5142e-177
NZ_LT992456.1\|WP_000660709.1\|1545947_1547225_+\|MFS-transporter	gnl\|CDD\|340877	cd17319, MFS_ExuT_GudP_like, Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily. This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.24287e-91
NZ_LT992456.1\|WP_031774865.1\|1569772_1570546_+\|tandem-type-lipoprotein	gnl\|CDD\|367972	pfam04507, DUF576, Csa1 family. This family contains several uncharacterized staphylococcal proteins. These proteins have been called conserved staphylococcal antigens (Csa).	3.80143e-129
NZ_LT992456.1\|WP_000083859.1\|1572451_1573807_+\|hypothetical-protein	gnl\|CDD\|238287	cd00519, Lipase_3, Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of becoming active at the lipid/water interface, although several examples of lipases have been identified that do not undergo interfacial activation . The active site of a lipase contains a catalytic triad consisting of Ser - His - Asp/Glu, but unlike most serine proteases, the active site is buried inside the structure. A "lid" or "flap" covers the active site, making it inaccessible to solvent and substrates. The lid opens during the process of interfacial activation, allowing the lipid substrate access to the active site. .	0.00130687
NZ_LT992456.1\|WP_000481425.1\|1554895_1556254_+\|gluconate-permease	gnl\|CDD\|129873	TIGR00791, Gluconate_permease, gluconate transporter. This family includes known gluconate transporters of E. coli and Bacillus species as well as an idonate transporter from E. coli. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	2.53789e-168
NZ_LT992456.1\|WP_000586373.1\|1548136_1549960_+\|FUSC-family-protein	gnl\|CDD\|224208	COG1289, COG1289, Predicted membrane protein [Function unknown].	1.43413e-83
NZ_LT992456.1\|WP_000282632.1\|1567311_1568505_-\|DNA-(cytosine-5-)-methyltransferase	gnl\|CDD\|273211	TIGR00675, Modification_methylase, DNA-methyltransferase (dcm). All proteins in this family for which functions are known are DNA-cytosine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair].	1.26934e-125
NZ_LT992456.1\|WP_000876645.1\|1553225_1554779_+\|gluconokinase	gnl\|CDD\|130381	TIGR01314, gntK_FGGY, gluconate kinase, FGGY type. Gluconate is derived from glucose in two steps. This model describes one form of gluconate kinase, belonging to the FGGY family of carbohydrate kinases. Gluconate kinase phosphoryates gluconate for entry into the Entner-Douderoff pathway. [Energy metabolism, Sugars].	0
NZ_LT992456.1\|WP_014653252.1\|1565484_1567236_-\|phospho-sugar-mutase	gnl\|CDD\|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NZ_LT992456.1\|WP_000289136.1\|1550745_1551438_+\|GTP-pyrophosphokinase-family-protein	gnl\|CDD\|225232	COG2357, COG2357, PpGpp synthetase catalytic domain [General function prediction only].	8.50652e-86

>NZ_LT992456.1|WP_000794645.1|1556722_1559776_+|fibronectin-binding-protein-FnbA
MKNNLRYGIRKHKLGAASVFLGTMIVVGMGQDKEAAASEQKTTTVEENGNSATENKTSETQTTATNVNHIEETQSYNATVTEQPSNATQVTTEEAPKAVQAPQTAQPANVETVKEEVVKEEAKPQVKETTQSQDNSGDQRQVDLTPKKATQNQAAETQVEVAQPRTVSESKPRVTRSADVVEAKEASDASEIKGTDVTSKVTVTESSIEGHNNTNKVEPHAGQRAVLKYKLKFEDGLKKGDYFDFTLSNNVNTYGVSTARKLPEIKNGSVVMATGQLLGDGKIRYTFTDYIDYKVNVIANLNLNLFIDPRIVKNNGEETLTSKLNGKNTEKKIEVEYKDGVGKYYTNLNGSIETFNKADNKFTHVAYVKPINGNKSESVSITGSLTQGSNVSGDSPIVKVYEYQGKETDLPKSVSVNLTDNSKFKDVTSDMQNKLTVQENGNYQLNLEKLDKTYVIHYTGEYSKETDEVNFRTQVSAYPENSYRYYSYYNNHYTLTWDNGLVLYSNKADGNGQNGVKVESNNLIFDEVTGTGVITGQYDKNLVTTVEEETDSSTLDIDYHTAIDGEGGYVDGYIETIEETDSSAIDIDYHTAVDSEAGHVGGYTESSEESNPIDFEESTHENSKHHADVVEYEEDTNPGGGQVTTESNLVEFDEESTKGIVTGAVSDHTTIEDTKEYTTESNLIELVDELPEEHGQAQGPIEEITENNHHISHSGLGTENGHGNYGVIEEIEENSHVDIKSELGYEGGQNSGNQSFEEDTEEDKPKYEQGGNIVDIDFDSVPQIHGQNNGNQSFEEDTEEDKPKYEQGGNIIDIDFDSVPQIHGFNKHNEIIEEDTNKDKPNYQFGGHNSVDFEEDTLPKVSGQNEGQQTIEEDTTPPTPPTPEVPSEPETPTPPTPEVPSEPETPTPPTPEVPSEPGEPTPPTPEVPAEPGKPVPPAKEEPKKPSKPVEQGKVVTPVIEINEKVKAVAPTKKAQSKKSELPETGGEESTNKGMLFGGLFSILGLALLRRNKKNHKA
>NZ_LT992456.1|WP_000481425.1|1554895_1556254_+|gluconate-permease
MFNEIWPLISVVLGIVILLVLIIGFKLNTFISLIITSMITALMLGIPLTKIMETIEKGMGSTLGHIALIFGLGAILGKLLADGGGATRIADTLIQKFGQKHVQWAMLVAAFIVGIALFFEVGLVLLIPLVFTVAKRANVSVLKLGLPMVTALSVTHGFLPPHPGPVVIAKELKANVGDVLLYGMIIAIPVTLIAGPIFNKVAQKMIPSAYTREGDISALGAQKEFTDQEMPGFGMSLLTATLPVILMLVSTITQLVTGHDKPTNLFESIIYMIGTAGTAMLIAVLFAIVTMGLMRKRKMNHIMESVTNAIYPIGMMLLIIGGGGTFKQVLIDGGVGNTIAKMFEGTEMSPILLAWIVAAVLRIALGSATVAAISTTGIVLPLLQSSDVNVALVVLAIGAGSVILSHVNDAGFWMFKEYFGLTVKETFLTWSLLETIISVSGIIFILFISLFV
>NZ_LT992456.1|WP_000876645.1|1553225_1554779_+|gluconokinase
MKYMIGVDIGTTSTKSVLYDENGTFIMKHQIGYDLHTPNVDVSEENPDELFDAVLMTIKYIMRESKVNQDDIKFVSFSAQMHSLIAMDQQHQRLTNNITWADNRAAKYATVINEVHDGNAIYQRTGTPIHPMSPLAKIFWMKHEWQDVFQRTAKFADIKTYIFYHLFDRYIIDYSMASATGMFNLETLDWDVGALELLGISEEMLPELVPTTYVMKGMKERYATLMGLNEDTPFVIGASDGVLSNLGVNSVGKGEVAVTIGTSGAIRTVIDKPRTDYKGRIFCYVLTEDHYVIGGPVNNGGVVLRWLRDELLASEVETAKRLGVDPYDVLTQIAKRVKPGADGLIFHPYLAGERAPLWNANARGSFFGLTLSHKKEHMIRAALEGVLYNLYTVYLALIEVMNETPKMIKATGGFAKSEVWRQMMSDIFDTELVVPESYESSCLGACVLGLKAVGDIEDFSIVSSMVGATNNHTPIEENVAVYQELESIFINLSRSLTENYEQISDFQRQHMAENKTQ
>NZ_LT992456.1|WP_000274558.1|1552523_1553201_+|GntR-family-transcriptional-regulator
MYGYPEKWLEGMTTGEGIAAELRLGIVNGHIAEGTLLTENQMAKQFNVSRSPIRDAFKLLQQNQLIQLERMGAHVLPFGEQEKKEMYDLRLMLESFAFSRVKNQERLPIVKEMKKQLEMMKVAVKFEDAESFTKHDFEFHETLIKASNHQYLNSFWSHLKPVMMALVLTSMRQRMQQNPQDFERIHHNHQVFIDAVEQYDSQILKEAFHLNFDDVGKDIEGFWLN
>NZ_LT992456.1|WP_000074000.1|1551602_1552367_+|MerR-family-transcriptional-regulator
MSNYSTGELAKLCNVTTRTIQYYDRKGILKPQGFTEGKRRVYTEQQRQTLELILLLKDLGCALSDIDMLLKGEGTLKTLNTLLTMKQQEINQQVKQQQAVLDKIKNVQYYVNEASTSPITHLKDIEHVMSKSAEMKSIRRNIWISAGIIGIIQYSSIISAILMKNKWPFLIALPFMISYGIGITIYYQRKVAYLCPNCQHIFSPSLWAVIKAKHTATTRRFECPNCHETHYCIEVPKTHMSTEQLEVPRTKNNN
>NZ_LT992456.1|WP_000289136.1|1550745_1551438_+|GTP-pyrophosphokinase-family-protein
MYVDRKPSLYLEDLRHDFKNSLSKFENGDEAFDTLLGFVELDHIYSSALKEISTKLSILDDNFNHIYKHNPIHHMERRVKEMRSLIEKLNRKGLQISAETAKEHILDIAGIRVVCNYLDDIYLIEEMLLKQEDVQLIKRKDYIQHPKENGYRSLHIVVSIPVFLAERVEVLPVEIQIRTIGMDMWASLEHKIRYKNNAETEKYRDLLKECATEITEVEDKLQQIHSEITE
>NZ_LT992456.1|WP_001117057.1|1550098_1550515_+|DUF2188-domain-containing-protein
MPFTMKGYPEKWKEFEVIKRQKAIEIANAMLKEGYLEKDVVPIAAKKAKDWYRALSKEEIKALEEENFVQFHTATMEKTEVDSEYATTDNEEHIQEQSNQDKSYFDSESIVNQSGGVRQREPLMDGPHPKVVESFKDV
>NZ_LT992456.1|WP_000586373.1|1548136_1549960_+|FUSC-family-protein
MIIPAIIGYLCGNFQFGLLVATGTLAHIYVFKGPSRSKLRTVIICNLAFAICMILGTLTATTPLVFGMTLLIVTVIPFYIFTALKIAGPSSTFFIVTFSLPINLPIAPEEALYRGFAILVGGVLATMMVLITILLSKNKAEEQAIQNDFKLISKLLHAYNDKSAFSQVAKTAVDSFKASDKLLITSNSSSDKLSGRFQKLLLLHTSAQGIYSELLELNAKQIRPLPDELIEMMDHIITQRDDRNKNVRYWRKEVTVTEEFQNLFNHILKIDEMVHANEARIAYEAEMRKPLYSKRIYQNLTLDSIVFRNTLRYAAIMMIAIFIALMFDFEKAYWIPLSAHTVLLGTSTIHAIERGIARGLGTILGVLVLSVILLFSIPTPVAVILMGIAALFTEALVGANYTIAVVFITIQVILMNGLASQNLTINIAFPRVIDVAMGIVIAIIGLFVLGQRTASALLPYVMAEVVRKEATLFHYLFSENQYKDDVYQKNTAMNLSVKLNNMTQVYNAANGELFSDKTLIQNYYPSLFALEEISFMLNRAMANEDRLTINEQLMGEYLATFENIAKHLELNTELEIKILPDLPQYNYIQSAMMNIQHNGFRERDKNV
>NZ_LT992456.1|WP_000660709.1|1545947_1547225_+|MFS-transporter
MKEKRTNVRWMFALAFFFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVLWAIIAKDLPEQHRMVNEAEKRFIMENRDIVATEKSSPPWNDFFKRFSFYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKEMSISSLPWLLMFFLILSAGAISDRVLGLGRSKFVARGVIAIAGFIVFAVSIIFAVRTGNLYVSIFWLSLGLGGIGISMGMSWAAATDLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVPAVIAVIMWFYVKPDQPLIVSDDKAIEK
>NZ_LT992456.1|WP_000435037.1|1544789_1545401_-|DedA-family-protein
MEQIITEFISRFGYAAIFILILLENILPIVPSEIILTFAGLMSVKSHLSILTLFIIATIASFIGLLILYYICRLISEERLYRFIDRHGKWIKLKSKDLKRANDWFKKYGVWAVFICRFIPVLRVLITIPAGVNRMNVVTFTVISLIGTTIWNFGLILLGRTLSDSFGMLMTGLHTYSRIMYVVIIIAVIYFAIRYIGKRKRVK
>NZ_LT992456.1|WP_000721337.1|1563490_1564357_+|UTP--glucose-1-phosphate-uridylyltransferase-GalU
MKKIKKAIIPAAGLGTRFLPATKAMPKEMLPILDKPTIQYIVEEAARAGIEDIIIVTGRHKRAIEDHFDSQKELEMVLKEKGKSELLEKVQYSTELANIFYVRQKEQKGLGHAISSARQFIGNEPFAVLLGDDIVESEVPAVKQLIDVYEETGHSVIGVQEVPEADTHRYGIIDPLTKNGRQYEVKKFVEKPAQGTAPSNLAIMGRYVLTPEIFDYLKTQKEGAGNEIQLTDAIERMNNDNQVYAYDFEGERYDVGEKLGFVKTTIEYALKDDSMREELTRFIKELGL
>NZ_LT992456.1|WP_000217726.1|1564482_1564791_-|hypothetical-protein
MTVNIVVSIVFCISMVVLSIYVAITKDFTLISYINQTTIADKHKNQIAYIFALCISLSAVFLMSAILCFEYDFIALAFLFLTIALLLIALFYVCFYKITKYP
>NZ_LT992456.1|WP_000678764.1|1564934_1565201_-|hypothetical-protein
MKGSKQILLIMGIISLIVLFIFTLFIMAQYAKHYEQKSDSSNAHTLNSSSAIIEQHTMSNLASLDLYAPVRNITSSRDIHPIYFMTKD
>NZ_LT992456.1|WP_014653252.1|1565484_1567236_-|phospho-sugar-mutase
MFFYFWGVFLYNSLHKCKGFSFHVLLSLTEILKGCLATMDKELWIERANDSLVKHFYEQQSDIEQREGFESKLTFGTAGIRGKFGLGEGRLNKFTIEKLALGLSRYLNAQTNNPTIVIHYDIRHLSTEFAQIIANVLANHQITVYLPDTYKTTPELSFAVRNLNTTAGIMITASHNPKDYNGIKVYGSDGAQLSTDASELVSRYIEDVGDPLQIDISFSKHNSSYIKPLPKSVAENYIKHIQNMIGYIPKSDLQVVFTSLHGTSVPIVPELLKSLNFNQFNLVEAQCKPDPNFSSVQSANPEDHRAFDQAVELANKSHADLLISTDPDADRLGIAERDAHGHITYFNGNQIGALLLNYRIQQTSQLRHRLMIQSIVSSELTKSLARYNNVEYKEVLTGFKFIAQEIRQLDDHQNMIFAFEESYGFLSEPFVRDKDAVQIVPLIIKYASELKLYGKTLKDELEQIYQTVGRHEDTLFSHTLEGLEGKKKIESIMTHFRSHPPQEIQGLKVKAIEDYLTSEVHQLDKDTTSQINSPKSNVIRVLFDEGFIALRPSGTEPKIKLYVSLKCPNFDDVAQKINAMIFS
>NZ_LT992456.1|WP_000282632.1|1567311_1568505_-|DNA-(cytosine-5-)-methyltransferase
MYNNIITKNESDNSIPLNYGDFIKEKRNKLNMTQKELADSIGLPKFGDRTIRRWENYETSPSYLEYKTIMNFPDTPPYLNPNIYDYKMIDLFAGIGGTRLGFQLHGNVKCVFSSEWDKFSAKTYKANFGETPKGDITQIIADEIPTHDILVAGFPCQAFSQAGLKKGFNDTRGTLFFDIARILKAKRPKCFLLENVKNLRSHDKGKTFDIIMNTLLELDYDVSSSILRARDFGCPQNRERIYIVGFDKQQIKNAENFSFPEPLPIETSLGSILESNVNDKYTISDRLWYGHQRRKREHKAKGNGFGYSIFNETSPYTNTLSARYYKDGSEILIEQNKKNPRKLTPREAARLQGFPENYIIPVSDTQAYKQFGNSVSVPVVHAIASNIFQVLQQNKNN
>NZ_LT992456.1|WP_016187290.1|1568600_1569530_+|hypothetical-protein
MTNLNNQLKEFKNTIKVERSKLLPSPFDMVYKNFEKLGYHKQNEQFFYDNASIIIDELRNQSWIEFKKIEKEFSKKLYSHLLDQDSENYKNMTVKEGIEKFTSKHTDEIYALQLSNTQSRRSRAGKEFESIIELVLMGANIEFVTQGSIGSGVFESSELAKLVDCVVPGAAEYNLNKRNTSLISTKTSLRERWQEVGDEMSRTKAKEMYLVTLDESISEKTLKLIEKNNIIIVTTKSVIDKNYLNSSNVISFEDMLNELHIQLLQWNNYGYPATELNNKKELYQTLIEKYDGNMFVRNYYENMLSNINV
>NZ_LT992456.1|WP_031774865.1|1569772_1570546_+|tandem-type-lipoprotein
MIHSRKLRLCLYLVLLAVFIGACGMKKEESSKDKQIKENFTKTLNLYPTKNLEDFYDKEGFRDQEFEKGDKGTWIVDSEMVIELKDKKMESRSMVLYINRNTRTTKGNFIVRELWEDSKGYAQSKDTKYPVKMEHNKIIPTKPIADDKLRKEIENFKFFVQYGDFKDINDYKDGDISYNSNVPSYSAKYQLSNDDYNVKQLRKRYDIPTKKAPKLLIKGDGDLKGSSIAHKNLEFTFIENKEENIYFTDSINFKPTE
>NZ_LT992456.1|WP_000581897.1|1570657_1571422_+|tandem-type-lipoprotein
MIHSKKLTLGICLVLLIILIVGYVIMTKTNGRNAQIKEAFNKTLNVYPTKNLEDFYDKEGFRDQEFDKRDKGTWIINSGMNIQLKGGALKSRAMVLYINRNTRTAKGYFLISETTEDKKGYVHNKDKKYPVKMEHNQIIPTKPIRDDKLKKEIENFKFFVQYGDFKDYKDGDISYNPNVPSYSANYQLNNDDYNVQQLRKRYDISTKRAPELKLRGSGDLKGSSVGSKELEFNFIRNKEENVYFTDSINFKPTE
>NZ_LT992456.1|WP_014937076.1|1571669_1572455_+|tandem-type-lipoprotein
MIHSKKLKLCLCLIILSVFIGGCGMKKEESSKDKQIKENFNKTLSLYPTKNLEDFYDKEGFRDEEFEKGDKGTWIIHSKMIIETNGRNMESRGMVLYINRNTRTTKGNFVIREITEDSKGYSDSKDKKYPVKMENNRIVPMKPIHDEKLRKEIEDFKFFVQYGNFKDINDYKDGDISYNPNVPSYSAKYQLSNDDYNVKQLRKRYDIPTKKAPKLLLKGDGDLKGSSVGSKNLEFTFVENKEENIYFTDSVQYTPSEDNNL
>NZ_LT992456.1|WP_000083859.1|1572451_1573807_+|hypothetical-protein
MSQTEYQIKPGNIKANSEETSTVSKISYEIENANNSGLKKGKINEQIEGLKEEGKFPKNLKYLKSYTDPNTGTTTTAFKNKDTGKVTLGMTGTNLHFEEMGNVLKHPFNHSDQDMKDMKEMLKDFGADANIGLGAVTDKDPHFKDTQDFIKDIKKEYEIDTITGHSLGGRDAIILGVSNDIKNIVVYNPAPLSITDFRIIALNNMTYSAIGDIEIKEMLKNYNGHIVRFVSDKDELDGFVSQFMYDTAGEKIVLNNGEGHDMGAFLRKYAQAKILAELRKVKGYEDANNKSFKSVKDNTKSKLGKVEELRVNWLQANGGALTSSQLKLLESVSALIIAEGLSQLVKEESNQLEKMYDNMKDKFQENWKNSQEAGNKIGTKLSHDGVLTALRNGDAYESKFETEPLTKIEQKLKELNDINSDCHNYVSKIKDSVNAIVGNDQLLASQIAGVI

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Crispr_ID: NZ_LT992456_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LT992456_5

1587356-1587450

Orphan

Consensus_repeat	Method
TTGCTTCGCAACAACTGCATAAGAGCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_LT992456_5

>merge|NZ_LT992456|5|1587356-1587450|CRISPRCasFinder
TTGCTTCGCAACAACTGCATAAGAGCCTCTAGTAATTAAAATTACAGTTTTAGAGGAATACAGTTGCTTGCTTCGCACCAACTGCATAAGAGCCT

>NZ_LT992456|5|3|1587356-1587450|CRISPRCasFinder
TTGCTTCGCAACAACTGCATAAGAGCCT	CTAGTAATTAAAATTACAGTTTTAGAGGAATACAGTTGC
TTGCTTCGCACCAACTGCATAAGAGCCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LT992456.1\|WP_000905462.1\|1580792_1581176_+\|DUF1433-domain-containing-protein	unknown	unknown	gnl\|CDD\|284628
NZ_LT992456.1\|WP_001807941.1\|1582067_1582466_+\|DUF1433-domain-containing-protein	unknown	unknown	gnl\|CDD\|284628
NZ_LT992456.1\|WP_000584764.1\|1593265_1594135_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_LT992456.1\|WP_000590515.1\|1594939_1595689_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224049
NZ_LT992456.1\|WP_000202032.1\|1583471_1585010_-\|AbgT-family-transporter	unknown	unknown	gnl\|CDD\|367668
NZ_LT992456.1\|WP_001081687.1\|1587635_1588457_+\|histidine-racemase-CntK	unknown	unknown	gnl\|CDD\|223331
NZ_LT992456.1\|WP_000143487.1\|1598057_1599635_+\|FMN-binding-glutamate-synthase-family-protein	unknown	unknown	gnl\|CDD\|223147
NZ_LT992456.1\|WP_000505991.1\|1579197_1579512_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LT992456.1\|WP_001146763.1\|1582937_1583360_+\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NZ_LT992456.1\|WP_000040594.1\|1589278_1590580_+\|staphylopine-dehydrogenase-CntM	unknown	unknown	gnl\|CDD\|226839
NZ_LT992456.1\|WP_000173877.1\|1594131_1594947_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_LT992456.1\|WP_000472235.1\|1592333_1593269_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_LT992456.1\|WP_000910577.1\|1586324_1586687_+\|hypothetical-protein	unknown	unknown	unknown
NZ_LT992456.1\|WP_000037506.1\|1581630_1582041_+\|DUF1433-domain-containing-protein	unknown	unknown	gnl\|CDD\|284628
NZ_LT992456.1\|WP_000824954.1\|1585243_1586062_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181491
NZ_LT992456.1\|WP_001058850.1\|1588467_1589286_+\|D-histidine-(S)-2-aminobutanoyltransferase-CntL	unknown	unknown	gnl\|CDD\|176222
NZ_LT992456.1\|WP_001229077.1\|1590722_1592321_+\|staphylopine-dependent-metal-ABC-transporter-substrate-binding-protein-CntA	unknown	unknown	gnl\|CDD\|274072
NZ_LT992456.1\|WP_001084931.1\|1579517_1580726_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|153341
NZ_LT992456.1\|WP_000072469.1\|1597116_1597863_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LT992456.1\|WP_001124998.1\|1576901_1577321_+\|DUF1433-domain-containing-protein	unknown	unknown	gnl\|CDD\|284628

Protein	Function_ID	Function_description	E-value
NZ_LT992456.1\|WP_000905462.1\|1580792_1581176_+\|DUF1433-domain-containing-protein	gnl\|CDD\|284628	pfam07252, DUF1433, Protein of unknown function (DUF1433). This family contains a number of hypothetical bacterial proteins of unknown function approximately 100 residues in length.	1.96173e-37
NZ_LT992456.1\|WP_001807941.1\|1582067_1582466_+\|DUF1433-domain-containing-protein	gnl\|CDD\|284628	pfam07252, DUF1433, Protein of unknown function (DUF1433). This family contains a number of hypothetical bacterial proteins of unknown function approximately 100 residues in length.	3.40871e-34
NZ_LT992456.1\|WP_000584764.1\|1593265_1594135_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.45335e-84
NZ_LT992456.1\|WP_000590515.1\|1594939_1595689_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224049	COG1124, DppF, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	5.955e-107
NZ_LT992456.1\|WP_001081687.1\|1587635_1588457_+\|histidine-racemase-CntK	gnl\|CDD\|223331	COG0253, DapF, Diaminopimelate epimerase [Amino acid transport and metabolism].	2.70571e-73
NZ_LT992456.1\|WP_000143487.1\|1598057_1599635_+\|FMN-binding-glutamate-synthase-family-protein	gnl\|CDD\|223147	COG0069, GltB, Glutamate synthase domain 2 [Amino acid transport and metabolism].	2.40496e-176
NZ_LT992456.1\|WP_000173877.1\|1594131_1594947_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	3.80608e-117
NZ_LT992456.1\|WP_001146763.1\|1582937_1583360_+\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	2.83513e-29
NZ_LT992456.1\|WP_000040594.1\|1589278_1590580_+\|staphylopine-dehydrogenase-CntM	gnl\|CDD\|226839	COG4408, COG4408, Uncharacterized protein conserved in bacteria [Function unknown].	0
NZ_LT992456.1\|WP_000472235.1\|1592333_1593269_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.46808e-99
NZ_LT992456.1\|WP_000202032.1\|1583471_1585010_-\|AbgT-family-transporter	gnl\|CDD\|367668	pfam03806, ABG_transport, AbgT putative transporter family.	0
NZ_LT992456.1\|WP_000037506.1\|1581630_1582041_+\|DUF1433-domain-containing-protein	gnl\|CDD\|284628	pfam07252, DUF1433, Protein of unknown function (DUF1433). This family contains a number of hypothetical bacterial proteins of unknown function approximately 100 residues in length.	5.68109e-39
NZ_LT992456.1\|WP_000824954.1\|1585243_1586062_+\|SDR-family-oxidoreductase	gnl\|CDD\|181491	PRK08589, PRK08589, SDR family oxidoreductase.	0
NZ_LT992456.1\|WP_001058850.1\|1588467_1589286_+\|D-histidine-(S)-2-aminobutanoyltransferase-CntL	gnl\|CDD\|176222	cd08261, Zn_ADH7, Alcohol dehydrogenases of the MDR family. This group contains members identified as related to zinc-dependent alcohol dehydrogenase and other members of the MDR family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group includes various activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	0.000104575
NZ_LT992456.1\|WP_001229077.1\|1590722_1592321_+\|staphylopine-dependent-metal-ABC-transporter-substrate-binding-protein-CntA	gnl\|CDD\|274072	TIGR02294, Nickel-binding_periplasmic_protein, nickel ABC transporter, nickel/metallophore periplasmic binding protein. Members of this family are periplasmic nickel-binding proteins of nickel ABC transporters. Most appear to be lipoproteins. This protein was previously (circa 2003) thought to mediate binding to nickel through water molecules, but is now thought to involve a chelating organic molecule, perhaps butane-1,2,4-tricarboxylate, acting as a metallophore. [Transport and binding proteins, Cations and iron carrying compounds].	0
NZ_LT992456.1\|WP_001084931.1\|1579517_1580726_-\|hypothetical-protein	gnl\|CDD\|153341	cd07657, F-BAR_Fes_Fer, The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) and Fer (Fes related) tyrosine kinases. F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. Fes (feline sarcoma), also called Fps (Fujinami poultry sarcoma), and Fer (Fes related) are cytoplasmic (or nonreceptor) tyrosine kinases that play roles in haematopoiesis, inflammation and immunity, growth factor signaling, cytoskeletal regulation, cell migration and adhesion, and the regulation of cell-cell interactions. Although Fes and Fer show redundancy in their biological functions, they show differences in their expression patterns. Fer is ubiquitously expressed while Fes is expressed predominantly in myeloid and endothelial cells. Fes and Fer contain an N-terminal F-BAR domain, an SH2 domain, and a C-terminal catalytic kinase domain. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules. The F-BAR domain of Fes is critical in its role in microtubule nucleation and bundling.	0.00836241
NZ_LT992456.1\|WP_001124998.1\|1576901_1577321_+\|DUF1433-domain-containing-protein	gnl\|CDD\|284628	pfam07252, DUF1433, Protein of unknown function (DUF1433). This family contains a number of hypothetical bacterial proteins of unknown function approximately 100 residues in length.	1.11006e-27

>NZ_LT992456.1|WP_000910577.1|1586324_1586687_+|hypothetical-protein
MLKEKESFRLLYQAIREIADKIGDNQLETNSVSLLLLDFDFEHEVFDELYLAILKYLNTVSIENISHSELLNLIENTIPEDREINTFVKNKIIIGFANNYFPELQVLANEIKSDMASSLK
>NZ_LT992456.1|WP_000824954.1|1585243_1586062_+|SDR-family-oxidoreductase
MKRLENKVAVVTGASTGIGQASAIALAQEGAYVLAVDIAEAVSKTVDKIKSNGDNAKAYTVDISDEQQVVDFVSDIKEQFGRIDVLFNNAGVDNAAGRIHEYPTDVYDKIMNVDMRGTFLMTKMMLPLMMTKGGSIVNTSSFSGQAADLYRSGYNAAKGAVINFTKSIAIEYGRDGIRANAIAPGTIETPLVDKLTGTSEDKEGKTFRENQKWMTPLGRLGKPEEVGKLVVFLASDESSFITGETIRIDGGVMAYTWPGEMLSDDSWKRTLE
>NZ_LT992456.1|WP_000202032.1|1583471_1585010_-|AbgT-family-transporter
MTSKHQQKGSIVNRFLNSVEKIGNKLPDPSVLFFLMCVGLAIMTWVISLFNVSVKHPGTHQTIYIKNIISHDGFTMIMNDTIKNFSEFPALGLVLAVMIGIGVAEKTGYFDKLMISVVNRAPRFLILPTIILIGILGSTAGDAATIILPPLAAMLFIKIGYHPIAGLTMAYASAVGGFAANIVVGMQDALVYSFTEPATRIVSDSIKTNVAMNWYFIAASVIVLLPTILLVTTKLIIPRLGQYDDRLMHDDHEETSSHITDKEAHALKWANISFIVTIILLIITAIPEHSFLRNAKTGSLLDDAPLINGVGLIILVVFLVPGLVYGILSKEIKNTKDLGKMFGDAVGSMGTFIVIVFFAAQLLAYLKWSNLGIIAAVKGAKLLEHQNGIVLILGIIVLSAMVNMLIGSASAKWGILGPIFVPMLILIGFHPAFTQVIYRVGDSITNPITPMMPYLPLLLTYAQKYDKRMKLGALLSSLMPYSIALSIVWTVFVIIWFLLGIPVGPGGPIFVK
>NZ_LT992456.1|WP_001146763.1|1582937_1583360_+|carboxymuconolactone-decarboxylase-family-protein
MPYNYKKQNGELMSVMSQGEKFIHQSPVNDELSALIKLLISKINGCHYCVDIHKKELKELGVTQMKIDEVLSFRHLDLFTDQEKVTLEFAEMLNSIKDFKKFEIIDRLKSFYDEEQIIDLVFVVNQINGWNRLNIISDRL
>NZ_LT992456.1|WP_001807941.1|1582067_1582466_+|DUF1433-domain-containing-protein
MNKKHVFIIIGVILCIRIVATVIYLKVKYDEKEKQKAIYYKEQQERITLYLKHNTKEPNTIKSVHFTSLKTGPMGDAVIEGYINENKKADFVAYGSPEHNYQFGGDMIESEKLSELLKPAQELKSQKKSKKN
>NZ_LT992456.1|WP_000037506.1|1581630_1582041_+|DUF1433-domain-containing-protein
MSKKHVFIIIGVILCICIVVTAMHLKMKYDEKEKRKAIYYKEQQARITLYLKHNTKEPNTIKSVHFTNLETSPMGSAVIEGYINENKKDNFTAYATPEHNYQFGGAMIKSEGVDKLLKPAHERKSPDDIKKELNKK
>NZ_LT992456.1|WP_000905462.1|1580792_1581176_+|DUF1433-domain-containing-protein
MLIILIIIVCVYLKIKIDEKEKQKAIYYKEQQERITLYLKHNTEEPNTIKSVHFTSLKRGPMGDAVIEGYINENKEDDFVAYGSPEHNYQFGGDMVESERLSELLKPAHERKSPDDIKKELNKKKNH
>NZ_LT992456.1|WP_001084931.1|1579517_1580726_-|hypothetical-protein
MNSIYDKDTTYRALAKEAYHLEPDQEKIFVPYSKEKKIEFRIVAFRQNKFNGLKMAGLSPVEKGAKLNTDELYIVYAGTDPDLLADFGSDSIEDLKVGMAKFGGGLRIPPTKKERAIYGNLNKKMIDYDDGISGISQNIMTNPISQSKESYIFTGALINKQKPKHVYGAAHSLGGGLALLNGVMYNFDGVRAFSAPNTFDLLPDEVKANYRSEKYDGKFINYLHRSDIIGNSDLFAQRIGTQIYGKDVGRFSLLNPILGHGMDTFEFKGDNVRIKMDTEEMSKIASDLKASCEFVNDAIKSYQKYMDDTKAAAKRIERKYTKKIRTGNYKHIKPSDIEDYMEELSVSGKYEFYNDTAFETVMSELNRIRKNVESFADKLKHAGEKMESRDKEIGELYKIFER
>NZ_LT992456.1|WP_000505991.1|1579197_1579512_-|hypothetical-protein
MGFLDDLAESIEEQSDLSEFKQAMKSELQTKVEEAKAKIESIDEDIWDWQTTVNNKRDAIEEYCEGKTAEHAIERLMQDKQDIAGMRWTAEDAEKSCKVGSWFW
>NZ_LT992456.1|WP_001124998.1|1576901_1577321_+|DUF1433-domain-containing-protein
MPKKTIFIIIGVILCISIVTGGIYLKMKHDEKEKQKEIYYKEQQERITLYLKHNTKEPNTIKTVHFTNLKTGPMGDIEIYGYINSKKDYDFIAYNSPEENYQFTGGLTGSNEVLGKLKNAENLKSPEKIKEELNNKKDH
>NZ_LT992456.1|WP_001081687.1|1587635_1588457_+|histidine-racemase-CntK
MNRQVIEFSKYNPSGNMTILVHSKHDASEYASIANQLMAATHVCCEQVGFIESTQNDDGNDFHLVMSGNEFCGNATMSYIHHLQESHLLKDQQFKVKVSGCSDLVQCAIHDCQYYEVQMPQAHRVVPTTINMGNHSWKAIEIIYETYVHYVIPVKQVTTEIQHLVETYVRKQQWNHKYKTVGMMLFDEQRQFLQPLIYIPEIQSLIWENSCGSGTASIGVFNNYQRNDACKDFTVHQPGGSILVTSKRCHQLGYQTSIKGQVTTVATGKAYIE
>NZ_LT992456.1|WP_001058850.1|1588467_1589286_+|D-histidine-(S)-2-aminobutanoyltransferase-CntL
MNNFNNEIKLILQQYLEKFEAHYERVLQDDQYIEALETLMDDYSEFILNPIYEQQFNAWRDVEEKAQLINSLQYITAQCVKQVEVIRARRLLDGQASTTGYFDNIEHCIDEEFGQCSIASNDKLLLVGSGAYPMTLIQVAKETGASVIGIDIDPQAVDLGRRIVNVLAPNEDITITDQKVSELKDIKDVTHIIFSSTIPLKYSILEELYDLTNENVVVAMRFGDGIKAIFNYPSQETAEDKWQCVNKHMRPQQIFDIALYKKAAIKVGITDV
>NZ_LT992456.1|WP_000040594.1|1589278_1590580_+|staphylopine-dehydrogenase-CntM
MSKLLMIGTGPVAIQLANICYLKSDYEIDMVGRASTSEKSKRLYQAYKKEKQFEVKIQNEAHQHLEGKFEINRLYKDVKNVKGEYETVVMACTADAYYDTLQQLSLETLQSVKHVILISPTFGSQMIVEQFMSKFSQDIEVISFSTYLGDTRIVDKEAPNHVLTTGVKKKLYMGSTYSNSTMCQRISVLAEQLKIQLEVVESPLHAETRNSSLYVHPPLFMNDFSLKAIFEGTDVPVYVYKLFPEGPITMTLIREMRLMWKEMMAILQAFRVPSVNLLQFMVKENYPVRPETLDEGDIEHFEILPDILQEYLLYVRYTAILIDPFSQPDENGHYFDFSAVPFKQVYKNEQDVVQIPRMPSEDYYRTAMIQHIGKMLGIKTPMIDQFLTRYEASCQAYKDMHQDQHLSSQFNTNLFEEDKALVTKFLEINRTLS
>NZ_LT992456.1|WP_001229077.1|1590722_1592321_+|staphylopine-dependent-metal-ABC-transporter-substrate-binding-protein-CntA
MRKLTKMSAMLLASGLILTGCGGNKGLEEKKENKQLTYTTVKDIGDMNPHVYGGSMSAESMIYEPLVRNTKDGIKPLLAKKWDVSEDGKTYTFHLRDDVKFHDGTPFDADAVKKNIDAVQENKKLHSWLKISTLIDNVKVKDKYTVELNLKEAYQPALAELAMPRPYVFVSPKDFKNGTTKDGVKKFDGTGPFKLGEHKKDESADFNKNDQYWGEKSKLNKVQAKVMPAGETAFLSMKKGETNFAFTDDRGTDSLDKDSLKQLKDTGDYQVKRSQPMNTKMLVVNSGKKDNAVSDKTVRQAIGHMVNRDKIAKEILDGQEKPATQLFAKNVTDINFDMPTRKYDLKKAESLLDEAGWKKGKDSDVRQKDGKNLEMAMYYDKGSSSQKEQAEYLQAEFKKMGIKLNINGETSDKIAERRTSGDYDLMFNQTWGLLYDPQSTIAAFKAKNGYESATSGIENKDKIYNSIDDAFKIQNGKERSDAYKNILKQIDDEGIFIPISHGSMTVVAPKDLEKVSFTQSQYELPFNEMQYK
>NZ_LT992456.1|WP_000472235.1|1592333_1593269_+|ABC-transporter-permease
MFKFILKRIALMFPLMIVVSFMTFLLTYITNENPAVTILHAQGTPNVTPELIAETNEKYGFNDPLLIQYKNWLLEAMQFNFGTSYITGDPVAERIGPAFMNTLKLTIISSVMVMITSIILGVVSALKRGKFTDRAIRSVAFFLTALPSYWIASILIIYVSVKLNILPTSGLTGPESYILPVIVITIAYAGIYFRNVRRSMVEQLNEDYVLYLRASGVKSITLMLHVLRNALQVAVSIFCMSIPMIMGGLVVIEYIFAWPGLGQLSLKAILEHDFPVIQAYVLIVAVLFIVFNTLADIINALLNPRLREGAR
>NZ_LT992456.1|WP_000584764.1|1593265_1594135_+|ABC-transporter-permease
MIILKRLLQDKGAVIALGIIVLYVFLGLAAPLVTFYDPNHIDTANKFAGMSFQHLLGTDHLGRDILTRLIYAIRPSLLYVFVALFVSVLIGSILGFLSGYFQGFVDALIMRACDVMLAFPSYVVTLALIALFGMGAENIIMAFILTRWAWFCRVIRTSVMQYTASDHVRFAKTIGMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQISGFSFLGLGVKAPTAEWGMMLNEARKVMFTHPEMMFAPGIAIVIIVMAFNFLSDALQIAIDPRISSKDKLRSVKKGVMQS
>NZ_LT992456.1|WP_000173877.1|1594131_1594947_+|ABC-transporter-ATP-binding-protein
MTLLTVKHLTITDTWTDQPLVSDVNFTLTKGETLGVIGESGSGKSITCKSIVGLNPERLRVTGDITFDGTSMLSLSESQLKKYRGKDIAMVMQQGSRAFDPSTTVGKQMFETMKVHTSMSTQEIEKTLIEYMDYLSLKDPKRILKSYPYMLSGGMLQRLMIALALALKPKLIIADEPTTALDTITQYDVLEAFIDIKKHFDCAMIFISHDLTVINKIADRVVVMKNGQLIEHGTRESVLHHPEHVYTKYLLSTKKKINDHFKHVMRGDVCD
>NZ_LT992456.1|WP_000590515.1|1594939_1595689_+|ABC-transporter-ATP-binding-protein
MIKIKDVEKSYQSAHVFKRRRTPIVKGVSFECPIGATIAIIGESGSGKSTLSRMILGIEKPDKGCVTLNDQPMHKKKVRRHQIGAVFQDYTSSLHPFQTVREILFEVMCQCDGQPKDVMEVQAITLLEEVGLSKAYMDKYPNMLSGGEAQRVAIARAICINPKYILFDEAISSLDMSIQTQILDLLIHLRETRQLSYIFITHDIQAATYLCDQLIIFKNGKIEEQIPTSALHKSDNAYTRELIEKQLSF
>NZ_LT992456.1|WP_000072469.1|1597116_1597863_-|hypothetical-protein
MSNTNKHYIEEYATEQSRFFKRDIGFIFLYIFLVNILPIIIVFLTFELVAVFTQQAPWGFSFPISMNISYLLAVIISLAIFRLMHEDAFIPMIRSQIVASAKYKWHILISFTLSIVLFLLLNHFDIFALNVDSFTVFDIYPLIREYGSISLIAIFSLTIILNTLICQLIFRHILIQELSRLIPLKITIVLSVILETLYYYPYINTWWEFIPALILASSATYLYLKSNRNFMVSYFYQLAVILVLHIFM
>NZ_LT992456.1|WP_000143487.1|1598057_1599635_+|FMN-binding-glutamate-synthase-family-protein
MTFLTVMQFIVNIIIIGFLLTVMVIGLIWLIKDKRQSQHSVLRNYPLLARIRYISEKMGPELRQYLFSGDNEGKPFSRNDYKNIVLAGKYNSRMTSFGTTKDYQDGFYIQNTMFPMQRNEISVDNTTLLSTFIYKIANERLFSREEYRVPTKIDPYYLSDDHAIKLGEHLKHPFILKRIVGQSGMSYGALGKNAITALSKGLAKAGTWMNTGEGGLSEYHLKGNGDIIFQIGPGLFGVRDKEGNFSEDLFKEVAQLSNVRAFELKLAQGAKTRGGHMEAEKVNEEIAKIRNVEPYKTINSPNRYEFIHNAEDLIRFVDQLQQLGQKPVGFKIVVSKVSEIETLVRTMVELDKYPSFITIDGGEGGTGATFQELQDGVGLPLFTALPIVSGMLEKYGIRDKVKLAASGKLVTPDKIAIALGLGADFVNIARGMMISVGCIMSQQCHMNTCPVGVATTDAKKEKALIVGEKQYRVTNYVTSLHEGLFNIAAAVGVSNPTEITADHIVYRKVDGELQTIHDYKLKLIS

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Crispr_ID: NZ_LT992456_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LT992456_6

1631702-1631780

Orphan

Consensus_repeat	Method
TGCAAGTTGGCGGGGCCCCAACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_LT992456_6

>merge|NZ_LT992456|6|1631702-1631780|CRISPRCasFinder
TGCAAGTTGGCGGGGCCCCAACACAGTAGCTGGCGGAAAGTCAGCTTACAATAATGTGCAAGTTGGCGGAGCCCCAACA

>NZ_LT992456|6|4|1631702-1631780|CRISPRCasFinder
TGCAAGTTGGCGGGGCCCCAACA	CAGTAGCTGGCGGAAAGTCAGCTTACAATAATG
TGCAAGTTGGCGGAGCCCCAACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LT992456.1\|WP_001191974.1\|1627227_1628439_-\|multidrug-effflux-MFS-transporter	unknown	unknown	gnl\|CDD\|340878
NZ_LT992456.1\|WP_001080281.1\|1625862_1626519_-\|C39-family-peptidase	unknown	unknown	gnl\|CDD\|227323
NZ_LT992456.1\|WP_000831300.1\|1628626_1629286_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LT992456.1\|WP_001110056.1\|1636723_1638082_+\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	unknown	unknown	gnl\|CDD\|273109
NZ_LT992456.1\|WP_001798790.1\|1635837_1636005_+\|hypothetical-protein	unknown	unknown	unknown
NZ_LT992456.1\|WP_000456489.1\|1626631_1627105_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226231
NZ_LT992456.1\|WP_000482647.1\|1631274_1631382_+\|type-I-toxin-antitoxin-system-Fst-family-toxin	unknown	unknown	unknown
NZ_LT992456.1\|WP_000200954.1\|1640897_1641365_+\|QueT-transporter-family-protein	unknown	unknown	gnl\|CDD\|377623
NZ_LT992456.1\|WP_001064818.1\|1632085_1633849_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_LT992456.1\|WP_000779355.1\|1630754_1631141_+\|flippase-GtxA	unknown	unknown	gnl\|CDD\|225155
NZ_LT992456.1\|WP_001217919.1\|1636059_1636746_+\|dethiobiotin-synthase	unknown	unknown	gnl\|CDD\|223210
NZ_LT992456.1\|WP_001046647.1\|1638083_1639091_+\|biotin-synthase-BioB	unknown	unknown	gnl\|CDD\|235755
NZ_LT992456.1\|WP_001185689.1\|1621082_1623161_-\|sodium:proton-antiporter	unknown	unknown	gnl\|CDD\|223104
NZ_LT992456.1\|WP_000286872.1\|1640194_1640887_+\|6-carboxyhexanoate--CoA-ligase	unknown	unknown	gnl\|CDD\|224342
NZ_LT992456.1\|WP_000483051.1\|1619114_1620944_+\|APC-family-permease	unknown	unknown	gnl\|CDD\|372624
NZ_LT992456.1\|WP_000486511.1\|1633873_1635607_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_LT992456.1\|WP_001176859.1\|1629345_1630488_-\|glycerate-kinase	unknown	unknown	gnl\|CDD\|272872
NZ_LT992456.1\|WP_000971556.1\|1639068_1640184_+\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223234
NZ_LT992456.1\|WP_000101538.1\|1623298_1624708_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NZ_LT992456.1\|WP_001056917.1\|1641416_1642394_-\|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B	unknown	unknown	gnl\|CDD\|273388

Protein	Function_ID	Function_description	E-value
NZ_LT992456.1\|WP_001191974.1\|1627227_1628439_-\|multidrug-effflux-MFS-transporter	gnl\|CDD\|340878	cd17320, MFS_MdfA_MDR_like, Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.96142e-74
NZ_LT992456.1\|WP_001080281.1\|1625862_1626519_-\|C39-family-peptidase	gnl\|CDD\|227323	COG4990, COG4990, Uncharacterized protein conserved in bacteria [Function unknown].	2.51069e-72
NZ_LT992456.1\|WP_000486511.1\|1633873_1635607_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.81449e-142
NZ_LT992456.1\|WP_001110056.1\|1636723_1638082_+\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	gnl\|CDD\|273109	TIGR00508, hypothetical_protein_DESPIG_00326, adenosylmethionine-8-amino-7-oxononanoate transaminase. All members of the seed alignment have been demonstrated experimentally to act as EC 2.6.1.62, an enzyme in the biotin biosynthetic pathway. Alternate names include 7,8-diaminopelargonic acid aminotransferase, DAPA aminotransferase, and adenosylmethionine-8-amino-7-oxononanoate aminotransferase. The gene symbol is bioA in E. coli and BIO3 in S. cerevisiae. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin].	0
NZ_LT992456.1\|WP_000286872.1\|1640194_1640887_+\|6-carboxyhexanoate--CoA-ligase	gnl\|CDD\|224342	COG1424, BioW, Pimeloyl-CoA synthetase [Coenzyme metabolism].	8.32691e-130
NZ_LT992456.1\|WP_000456489.1\|1626631_1627105_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|226231	COG3708, COG3708, Uncharacterized protein conserved in bacteria [Function unknown].	1.70839e-37
NZ_LT992456.1\|WP_001064818.1\|1632085_1633849_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	6.56982e-144
NZ_LT992456.1\|WP_000779355.1\|1630754_1631141_+\|flippase-GtxA	gnl\|CDD\|225155	COG2246, COG2246, Predicted membrane protein [Function unknown].	4.41648e-23
NZ_LT992456.1\|WP_001217919.1\|1636059_1636746_+\|dethiobiotin-synthase	gnl\|CDD\|223210	COG0132, BioD, Dethiobiotin synthetase [Coenzyme metabolism].	2.3746e-69
NZ_LT992456.1\|WP_001046647.1\|1638083_1639091_+\|biotin-synthase-BioB	gnl\|CDD\|235755	PRK06256, PRK06256, biotin synthase; Validated.	0
NZ_LT992456.1\|WP_001185689.1\|1621082_1623161_-\|sodium:proton-antiporter	gnl\|CDD\|223104	COG0025, NhaP, NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].	5.70788e-103
NZ_LT992456.1\|WP_000200954.1\|1640897_1641365_+\|QueT-transporter-family-protein	gnl\|CDD\|377623	pfam06177, QueT, QueT transporter. This family includes the queT gene encoding a hypothetical integral membrane protein with 5 predicted transmembrane regions. The queT genes in Firmicutes are often preceded by the PreQ1 (7-aminomethyl-7-deazaguanine) riboswitches of two distinct classes, suggesting involvement of the QueT transporters in uptake of a queuosine biosynthetic intermediate.	0.00118414
NZ_LT992456.1\|WP_000483051.1\|1619114_1620944_+\|APC-family-permease	gnl\|CDD\|372624	pfam13520, AA_permease_2, Amino acid permease.	1.57672e-32
NZ_LT992456.1\|WP_001176859.1\|1629345_1630488_-\|glycerate-kinase	gnl\|CDD\|272872	TIGR00045, Glycerate_kinase, glycerate kinase. The only characterized member of this family so far is the glycerate kinase GlxK (EC 2.7.1.31) of E. coli. This enzyme acts after glyoxylate carboligase and 2-hydroxy-3-oxopropionate reductase (tartronate semialdehyde reductase) in the conversion of glyoxylate to 3-phosphoglycerate (the D-glycerate pathway) as a part of allantoin degradation. [Energy metabolism, Other].	0
NZ_LT992456.1\|WP_000971556.1\|1639068_1640184_+\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	gnl\|CDD\|223234	COG0156, BioF, 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism].	7.0088e-136
NZ_LT992456.1\|WP_000101538.1\|1623298_1624708_-\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	0
NZ_LT992456.1\|WP_001056917.1\|1641416_1642394_-\|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B	gnl\|CDD\|273388	TIGR01002, synergohymenotropic_toxin, beta-channel forming cytolysin. This family of cytolytic pore-forming proteins includes alpha toxin and leukocidin F and S subunits from Staphylococcus aureus, hemolysin II of Bacillus cereus, and related toxins. [Cellular processes, Toxin production and resistance].	2.43039e-128

>NZ_LT992456.1|WP_000482647.1|1631274_1631382_+|type-I-toxin-antitoxin-system-Fst-family-toxin
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK
>NZ_LT992456.1|WP_000779355.1|1630754_1631141_+|flippase-GtxA
MKLTQTHAEILKFIIVGGINTLNYYVVYLLLLKLLHIEYMISHITGFIVAFVISYYLNCYFVYRVKPTWRKFISFPITQLVNVSLQTVLLYVFVSWLNLPAEIAPFAGLIITIPITFILSKWILKDSN
>NZ_LT992456.1|WP_001176859.1|1629345_1630488_-|glycerate-kinase
MQLQKIVIAPDSFKESMTAQQVGNIIKQAFTNVYGNTLHYDIIPMADGGEGTTDALMHATGATKYTVIVNDPLMRPIEACYARADEQQIAIIEMAAASGLDLLEKEERNPLYTSSYGTGELIKDALNHGAKTIILGIGGSATNDGGTGMLSALGVKFTDVNGDLLQMNGANLAHIAQIDITNLDSRLKEVTFKVACDVSNPLLGENGATYIYGPQKGADAKMIPKLDFAMSHYHDKIKICTGKSVNQVPGSGAAGGMGAALLAFFDTTLTKGIDIVFDITNFHQRIKDADLIITGEGRMDYQTIFGKTPVGVALAAKQYHIPVIAICGSLGENYQHVYDFGIDSAYSIISSPSTLEDVLQNSEQNLLNTATDIARILKLQ
>NZ_LT992456.1|WP_000831300.1|1628626_1629286_-|hypothetical-protein
MKRTDKYRDSYQYDNQNQNHRRQSEDASYRQQYAKGDPEEHPERYYNGRDYRREQILEEENEKSRRSKKWLYIIIAILLIIVAIFVTRALLNNDSDKVSNDPKVSQNYKKQVENQDGQINQQVDNAKENIKNNQKTDDIIKNLQNQIDNLKQQEQNKADSKLTQFYQDQINKLTEANNALKNNASQGKIESMLNDINTKFDSIKSKLESLFKDDNSGGN
>NZ_LT992456.1|WP_001191974.1|1627227_1628439_-|multidrug-effflux-MFS-transporter
MQSSSSKTKQFSFLLLITLGVMTAFGPLTIDMYVPSLPKVQGDFGSTTSEIQLTLSFTMIGLALGQFIFGPLSDAFGRKRIAVSILIIFILASGLSMFVDQLPLFLTLRFIQGLTGGGVIVIAKASAGDKFSGNALAKFLASLMVVNGIITILAPLAGGLALSVATWRSIFTILTIVALIILIGVASQLPKTPKEELKQVNFSSVIKDFGSLLKKPAFIIPMLLQGLTYVMLFSYSSASPFITQKLYNMTPQQFSMMFAVNGVGLIIVSQVVALLVEKLHRHILLIILTIIQVVGVALIILTLTFHLPLWVLLIAFFLNVCPVTSIGPLGFTMAMEERTGGSGNASSLLGLFQFILGGAVAPLVGLKGEFNTSPYMIIIFITAILLVSLQIIYFKMIKKQHVA
>NZ_LT992456.1|WP_000456489.1|1626631_1627105_+|AraC-family-transcriptional-regulator
MEYQLQQLASLTLVGIKETYENGRQAQQHIAGFWQRCYQEGVIADLQLKNNGDLAGILGLCIPELDGKMSYMIAVTGDNSADIEKYDVITLASSKYMVFEAQGAVPKAVQQKMEEVHHYIHQYQADTVKSAPFFELYQDGDTTSEKYITEIWMPVKG
>NZ_LT992456.1|WP_001080281.1|1625862_1626519_-|C39-family-peptidase
MNRKILPVKPISQLFPIPMVMGCEGVSAAMMLQYNNQHIPATEIMRHWPTHPNNPHKGYVGHHLFIKLGNYHQTIFPEAYVPFLQKYNPNIVDGTGKSLEDLKGIIDQGQPVLIYHTNLGSKPLLRVFRFDNKPAKQVSNIHVTLLIGYDDYYYYYIDPLWSHIRRGLVLPAIIPNRKQIIKIRKEKMEYSFNSPGRKCIYVQPHSYTIENQQQNKHT
>NZ_LT992456.1|WP_000101538.1|1623298_1624708_-|amino-acid-permease
MARKLHRELNNRHIQLIAIGGAIGTGLFLGSGQTISLTGPSLLFTYMIIGVVLFAFMRALGELLLSNTRFNSFVDIANEYLGPFGGFVIGWTYWLCWIVSSMSDLTAMGQYFAFWYPQVPNWITVLFIVLILISFNLLGARLFGELEFWFSIIKVVTIIAMVIVGLVLIFFSFKTHYGHASFTNLISHGGMFPGGTFGFLMSFQIAVYSFIGIELIGVTAGETKDPEKTLPKAINNVPIRILLFYIGGLLVIMSVIPWNDIDPNSSPFVKLFTLIGVPFAAGVVNFVVLTAAASATNSGIYSNSRILFGLSQQGLGPKVLNKTNSHGVPYLSMLVSSIALLIAALLNYIFPNAIQLFIYVTTLSTVLFLVVWAMIIVAYLMYLKKHPEAHKNSKFKLIGGKPIAYIILAFFFFVFILLFFSDETRAAIYISPFWFIFLFFFYKKYKTNAEKLAYEQRQNDSGHFRYDNQ
>NZ_LT992456.1|WP_001185689.1|1621082_1623161_-|sodium:proton-antiporter
MALLEAFLIFIFAVIISSVINNRFPQIPTAFIQIALGVVIFIIPIQVDFQFNSEVFMFAVIAPLLFVEGTHVSRTKLLEYRKPILLMSMALVFATVVGVGYFIHWIWPALPMPAAFAIAAILCPTDAVAVSAITRGKLLPKGSMTILEGESLLNDAAGIISFKIAVTALVTGTFSLFQAVEQFIISTILGVLIGAIIGFVVVRIRIDLTANKGLKDNNTLTFIQLLTPFVVYFLAEEVHASGIIAVVIAGLIHGLERDRLIRAQTELQMNYHQIWNTFSYALNGFVFVVLGFMIPTVVIDIFQTEPDNFSFLIVITILIAIAIYACRFVWVYFWYKDFYFPKNIQSYLDEEHDSHETPPSRVRYAFIMTMCGIHGTISLSMALTLPFIITKGQAFEYRNDLLFIASFMVLISLILAQIVLPLITPSAEDTTFKGMTYQSAKIFIVQKVIEHFKNESKKDKNDTNYRPVLNQYFGELLFLLNSEPDNQNTKELKRLEDIAKVIETSTLERLIDKGKATYQDINNYRNIVELTETHRTASFVEKFANFFKMLWLRLKAMKHYKALNKESKKQEFENSFKDVQKIMRIVNHNIILRLKEEQNSTNVLEVSLVINHYYDMSRSLKWRAQRRKERQENSNQIIPQAMFHNHKLEALYLQRHLLDELIRKNKINNIVAAQIRENINYNEIVLSLQSKH
>NZ_LT992456.1|WP_000483051.1|1619114_1620944_+|APC-family-permease
MFNQFKRLIIGQPKKNRELKDEKISKFKGLAILSSDALSSVAYGPEQILITLSVVGAVATWYTLPIAGAVLILLAALIMSYRQIIYAYPKGGGAYMVSKTNLGEKWGLLAGGSLLVDYILTVAVSISSGADAFVAAFPSLYGHKVLIACLLVLFILILNLRGLTESATVLSYPVYLFIIGLVILIFIGTFRVATGDIQPHMHASVGTAVPGVTLFLLLKAFSSGASSLTGVEAISNAVTNFREPSANNAVKTLIAMGSILAFLLVGIVGLAYVYGIMPQTETTVLSQLAMQIFGDNAAFYFVQATTVMILVLAANTGFTAFPMLAASMSKDKYMPRMFTVRGDRLGYSNSIIILGVLAIILIIVFDGMTEDLIPLYAVGVFIPFTLAQFGMVIKWIHERPKNWLSKLSVNLLGGIVTFIVFMILLITKFSQVWPILIFLPFVVIFFLKINKHYRDIAEQLRSDIDVHNVEVVDRNLAIVPITSITTAVDKSIYYAQMLANNDVIAVHVSFGDEDEKAFQEKWKRHFPDVRLVILHSEYRSIIRPISRFIDKINRKANDQNYMITVVIPEFITKKRWHNLLHNQTSLRMKLYLIYQKNVNVCTIPFKLKK
>NZ_LT992456.1|WP_001064818.1|1632085_1633849_+|ABC-transporter-ATP-binding-protein
MNNQTNWIKILSGFASDSKWKIMLSILLSIISVFSGLVPYWAVFKIILMMINNAYTINSIMVYIFIALIAYISQVCCFGASTMLSHITAYEILSEIRKKLAQKLMRLPLGVVESKKIGELKNIFVDKVETIELPLAHMIPEVIGNLLLSAAIFLYIMLIDWRMASALLVTIPISIFAFKKVMSGFNETYAEQMKSNNYMNSAIVEFIEGIEVIKTFNQSQSSYKKYKDAVDNYKIHTLNWFKNTWGYMNLGSSVLPSTFLGILPVGMYLISINQLNYAEFFLCIVLSLGVVAPIKNFTNYVNHLKSIQYALTEVNQLLILEELALSSRFMEPQHYEIAFNNVGFSYNKDKDDLVFKHLSFTVPENNFTAIVGASGSGKSTIAKLISRYWDVTSGEITIGGINIKDIESKQLNDLVGFVGQDNFLLNLTFKENIKLGNPEATDEAVEKAAKLAQCHEFIEKLPDGYDTNVGTVGDKLSGGEKQRVTIARMILKDAPIIVLDEATAYVDPDNEQKIQEALNVLTQDKTLIVIAHRLSTIQHADQIIVLGKQQILEKGSHHLLLKLNGNYKKMWDTHMHTKDWGINTGHN
>NZ_LT992456.1|WP_000486511.1|1633873_1635607_+|ABC-transporter-ATP-binding-protein
MFQITFKILNWMRPYKARMILGFSMSFLNAIFIALPIFLAAKIFNNVLSHKPIYMKDILNVVIIMVLLVIGRFITAYFKSKSHESIAYEMSAKERLDIGDKLKNVRLGYFNSHHSNELTTIVTTDLTFLENFAMKMVDVVVNGYILIIVLILSLLVVSWQVSLLACIGVLLSFFAIQLLERKSRQNAPAYHNVQNQLVEKVLEVIRGIQVIKSFAKENTSLKSFNQSVNESKRINTKIEMQYIPFNLLHLLSLKVVSIMIVLVACLLYMNHSIDLPTLIMISIFSFVIFDSVENINSAAHVLEMIDMTIDDIEKIKNAPELDENGKNLTIKNENIAFQNVNFSYDDKQVIKNVNFEIPTQTSTAIIGPSGSGKSTLCHLLLRFYDIDDGIIRIDGVDIKDMTLSTLMSKISAVFQKVYLFNDTIENNILFGNPGATKEEIIRAAKQACCHDFIMSLPEGYQTMLNEKGSNLSGGEKQRISIARAILKDAPIIILDEATSSIDPENEQLIQTAINELSKGKTVITIAHKLETIKNADQIIVLNEGEIIQKGSHDELIRKPGMYQDFIRIKSKSAGWKL
>NZ_LT992456.1|WP_001798790.1|1635837_1636005_+|hypothetical-protein
MQLLISTDIFYRIAVYICPNSVRSLSHFNSKVKILPKFIVILGSLNSCFLEKHAP
>NZ_LT992456.1|WP_001217919.1|1636059_1636746_+|dethiobiotin-synthase
MRIFITSTNTDVGKTYVTKHLYHALKTRGHRVCVFKPFQTEERQDGTFPDLEVFKNECDLSYDITSLYTFKQPVSPHLAFKMADQIFLNKQCVLDKVKVLDKEFDFILIEGAGGIGVPIYEGTDDFYMTKDLINDCADCVISVLPSKLGAISDAIVHQDYVNHNVSARNFLIMNRYTDSYIEKDNQMTIGKLTNKTVYTFEEHATYENFSEAFLKQLIGVKNELHTTT
>NZ_LT992456.1|WP_001110056.1|1636723_1638082_+|adenosylmethionine--8-amino-7-oxononanoate-transaminase
MNYTQQLKQKDSEYVWHPFTQMGVYSKEEAIIIEKGKGSYLYDTNGNKYLDGYASLWVNVHGHNNKYLNKVIKKQLNKIAHSTLLGLSNIPSIELAEKLIEITPSNLRKVFYSDTGSASVEIAIKMAYQYWKNIDREKYAKKNKFITLNHGYHGDTIGAVSVGGIKTFHKIFKDLIFENIQVESPSFYRSNYDTENEMMAAILTNIEQILIERNDEIAGFILEPLIQGATGLFVHPKGFLKEVEKLCKKYDVLLICDEVAVGFGRTGKMFACNHEDVQPDIMCLGKAITGGYLPLAATLTSQKIYNAFLSDSHGVNTFFHGHTYTGNQIVCTVALENIRLYEKRKLLSHIETTSSTLEKQLHALKRHRNVGDVRGRGLMFGVELVTDKDSKTPLEIEKVERIVRNCKENGLMIRNLENVITFVPVLSMSNKEVKTMVRIFKKAVHNILDRKC
>NZ_LT992456.1|WP_001046647.1|1638083_1639091_+|biotin-synthase-BioB
MNLAKRILQGEQLTKETVLKIYEDTNIDTLDLLNEAYILRKHYFGKKVKLNMILNAKSGICPENCGYCGQSRDIKQKQRYALIPEEQIIDGAKVAHDNHIGTYCIVMSGRGPSDKEVDHISNTVRTIKSQHPQLKICACLGLTNDEQAKKLKSAGVDRYNHNINTSENYHDNVVTTHSYKDRTDTIELMKANNISPCSGVICGMGESNQDIVDMAFALKEMDADSIPINFLHPIKGTKFGSMDDLTPMKCLRIVALFRLINPTKEIRIAGGREVNLRSLQPLALKAANSIFVGDYLITGGQPNQLDYDMINDLGFEIDYGTCENKENKNDVSRAN
>NZ_LT992456.1|WP_000971556.1|1639068_1640184_+|pyridoxal-phosphate-dependent-aminotransferase-family-protein
MMFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDQVDFESFMRKYSYHLSSSRLISGSSTVYEEIESMLADWLGYSACTILNSGYDANLALFNIFKNTNCVVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLAEYPNQNIPKIIISDSVFSTNGDVVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGIDILTSSLSKACGAYGGVILSSNDVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLKALNVNYNSSNSPIKFIEFDDIEAAENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHAEQDIDRLFEILHQED
>NZ_LT992456.1|WP_000286872.1|1640194_1640887_+|6-carboxyhexanoate--CoA-ligase
MYSIKMRSSNQDVHISGAETICEFDKIEQTVQRFYNKGFFHENGQPDFLNIKIQKIMEPIQQIKALQIIDDDKANLQHLTQECGVTEQALNQGMTYIKNETVYTGAIILSAISGKRLDSFGQRGIRATHFSFEDINNKGDLNERVTDALAIASCINAHPYVKGELCVSDDLTYTTGYFASAKIGYHRLFDIKPVNTRYGGRIIFVDDRIDLNHYISFLESTPKQVIYETV
>NZ_LT992456.1|WP_000200954.1|1640897_1641365_+|QueT-transporter-family-protein
MTSKDITQISVIAAILTILAVLKIPSIIPGLDFQLSAPAALLILAFFGIKKYFLGGLLSSVLLLIFGVFNPINVIISIIFRVIAIAVVYLLKINVLSLVLASVLGSLVSRLLLSIILNLPVWVVLLNAIPGVIFTLIVAIPLYLTLRKRMAVLLR
>NZ_LT992456.1|WP_001056917.1|1641416_1642394_-|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B
MNMNKLVKSSVATSMALLLLSNTANAEGKITPVSVKKVDDKVTLYKTTATADSDKFKISQILTFNFIKDKSYDKDTLVLKAAGNINSGYERPNPKDYDFSKIYWGAKYNVSISSQSNDSVNVVDYAPKNQNEEFQVQNTLGYTFGGDISISNGLSGGLNGNTAFSETINYKQESYRTTLSRNTNYKNVGWGVEAHKIMNNGWGPYGRDSFHPTYGNELFLAGRQSSAYAGQNFIAQHQMPLLSRSNFNPEFLSVLSHRQDGAKKSKITVTYQREMDLYQIRWNGFYWAGANYKNFKTRTFKSTYEIDWENHKVKLLDTKETENNK

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Crispr_ID: NZ_LT992456_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LT992456_7

1763572-1763657

Orphan

Consensus_repeat	Method
CCAACTTGCACATTATTGTAAGCTGACTTT	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NZ_LT992456_7

>merge|NZ_LT992456|7|1763572-1763657|CRISPRCasFinder
CCAACTTGCACATTATTGTAAGCTGACTTTCCGCCAGCTTCTATGTTGGGGCCCCGCCAACTTGCACATTATTGTAAGCTGACTTT

>NZ_LT992456|7|5|1763572-1763657|CRISPRCasFinder
CCAACTTGCACATTATTGTAAGCTGACTTT	CCGCCAGCTTCTATGTTGGGGCCCCG
CCAACTTGCACATTATTGTAAGCTGACTTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LT992456.1\|WP_000717395.1\|1770980_1771790_-\|CHAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NZ_LT992456.1\|WP_000606724.1\|1753969_1754299_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LT992456.1\|WP_001155267.1\|1758665_1761620_+\|formate-dehydrogenase-subunit-alpha	unknown	unknown	gnl\|CDD\|225918
NZ_LT992456.1\|WP_000417008.1\|1765243_1766197_-\|2-hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240655
NZ_LT992456.1\|WP_001826088.1\|1770717_1770912_+\|hypothetical-protein	unknown	unknown	unknown
NZ_LT992456.1\|WP_000032840.1\|1774380_1775124_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|130944
NZ_LT992456.1\|WP_001030125.1\|1755109_1755802_-\|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NZ_LT992456.1\|WP_000921246.1\|1762387_1762621_+\|hypothetical-protein	unknown	unknown	unknown
NZ_LT992456.1\|WP_000426692.1\|1754347_1755085_+\|CPBP-family-intramembrane-metalloprotease-SdpB	unknown	unknown	gnl\|CDD\|376806
NZ_LT992456.1\|WP_000684571.1\|1767966_1769049_+\|NAD/NADP-octopine/nopaline-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|376763
NZ_LT992456.1\|WP_000831053.1\|1757116_1758064_+\|LCP-family-protein	unknown	unknown	gnl\|CDD\|181811
NZ_LT992456.1\|WP_000073196.1\|1752652_1753525_-\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_LT992456.1\|WP_000684154.1\|1764027_1765152_+\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|168661
NZ_LT992456.1\|WP_000840813.1\|1761619_1762093_+\|DUF1641-domain-containing-protein	unknown	unknown	gnl\|CDD\|225283
NZ_LT992456.1\|WP_114668444.1\|1769143_1770544_+\|Na+/H+-antiporter-NhaC	unknown	unknown	gnl\|CDD\|188097
NZ_LT992456.1\|WP_000206106.1\|1767296_1767719_-\|DUF4870-domain-containing-protein	unknown	unknown	gnl\|CDD\|225833
NZ_LT992456.1\|WP_000739235.1\|1762642_1763419_+\|glucosaminidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|226656
NZ_LT992456.1\|WP_000737699.1\|1766559_1767060_-\|CHAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NZ_LT992456.1\|WP_000130460.1\|1756186_1756984_+\|inositol-monophosphatase	unknown	unknown	gnl\|CDD\|223559
NZ_LT992456.1\|WP_000131824.1\|1772399_1774355_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117

Protein	Function_ID	Function_description	E-value
NZ_LT992456.1\|WP_000717395.1\|1770980_1771790_-\|CHAP-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	9.81396e-31
NZ_LT992456.1\|WP_001155267.1\|1758665_1761620_+\|formate-dehydrogenase-subunit-alpha	gnl\|CDD\|225918	COG3383, COG3383, Uncharacterized anaerobic dehydrogenase [General function prediction only].	0
NZ_LT992456.1\|WP_000417008.1\|1765243_1766197_-\|2-hydroxyacid-dehydrogenase	gnl\|CDD\|240655	cd12178, 2-Hacid_dh_13, Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	0
NZ_LT992456.1\|WP_000032840.1\|1774380_1775124_+\|transcriptional-regulator	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	2.02961e-26
NZ_LT992456.1\|WP_001030125.1\|1755109_1755802_-\|YafY-family-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	3.1353e-57
NZ_LT992456.1\|WP_000206106.1\|1767296_1767719_-\|DUF4870-domain-containing-protein	gnl\|CDD\|225833	COG3296, COG3296, Uncharacterized protein conserved in bacteria [Function unknown].	7.90586e-53
NZ_LT992456.1\|WP_000426692.1\|1754347_1755085_+\|CPBP-family-intramembrane-metalloprotease-SdpB	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	3.30887e-10
NZ_LT992456.1\|WP_000831053.1\|1757116_1758064_+\|LCP-family-protein	gnl\|CDD\|181811	PRK09379, PRK09379, LytR family transcriptional regulator.	2.88129e-98
NZ_LT992456.1\|WP_000073196.1\|1752652_1753525_-\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	1.12128e-80
NZ_LT992456.1\|WP_000684154.1\|1764027_1765152_+\|FAD-dependent-monooxygenase	gnl\|CDD\|168661	PRK06753, PRK06753, hypothetical protein; Provisional.	0
NZ_LT992456.1\|WP_000840813.1\|1761619_1762093_+\|DUF1641-domain-containing-protein	gnl\|CDD\|225283	COG2427, COG2427, Uncharacterized conserved protein [Function unknown].	1.05607e-29
NZ_LT992456.1\|WP_114668444.1\|1769143_1770544_+\|Na+/H+-antiporter-NhaC	gnl\|CDD\|188097	TIGR00931, Uncharacterized_Na+/H+_antiporter_HI_1107, Na+/H+ antiporter NhaC. A single member of the NhaC family, a protein from Bacillus firmus, has been functionally characterized.It is involved in pH homeostasis and sodium extrusion. Members of the NhaC family are found in both Gram-negative bacteria and Gram-positive bacteria. Intriguingly, archaeal homolog ArcD (just outside boundaries of family) has been identified as an arginine/ornithine antiporter. [Transport and binding proteins, Cations and iron carrying compounds].	5.42284e-114
NZ_LT992456.1\|WP_000684571.1\|1767966_1769049_+\|NAD/NADP-octopine/nopaline-dehydrogenase-family-protein	gnl\|CDD\|376763	pfam02317, Octopine_DH, NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain. This group of enzymes act on the CH-NH substrate bond using NAD(+) or NADP(+) as an acceptor. The Pfam family consists mainly of octopine and nopaline dehydrogenases from Ti plasmids.	2.04121e-47
NZ_LT992456.1\|WP_000739235.1\|1762642_1763419_+\|glucosaminidase-domain-containing-protein	gnl\|CDD\|226656	COG4193, LytD, Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism].	6.77563e-118
NZ_LT992456.1\|WP_000737699.1\|1766559_1767060_-\|CHAP-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	3.97694e-33
NZ_LT992456.1\|WP_000130460.1\|1756186_1756984_+\|inositol-monophosphatase	gnl\|CDD\|223559	COG0483, SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism].	7.03254e-72
NZ_LT992456.1\|WP_000131824.1\|1772399_1774355_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.66555e-14

>NZ_LT992456.1|WP_000739235.1|1762642_1763419_+|glucosaminidase-domain-containing-protein
MKKNFKLRISTLLLIVILVVFSVLLIVNETKLFKNDVNYSFDEAVSMQQGKGIVQTKEEDGKFVEANNNEIAKAMTISHKDNDMKYMDITEKVPMSESEVNQLLKGKGILENRGKVFLEAQEKYEVNVIYLVSHALVETGNGKSELAKGIKDGKKRYYNFFGIGAFDSSAVRSGKSYAEKEQWTSPDKAILGGAKFIRNEYFENNQLNLYQMRWNPENPAQHQYASDIRWADKIAKLMDKSYKQFGIKKDDIRQTYYK
>NZ_LT992456.1|WP_000921246.1|1762387_1762621_+|hypothetical-protein
MLKTSAVISNTLLVIGLVCLFMMKLVLAITFFAVSLSISLVVFNMMFRDRTTMKVIVNASFLIVILAIVVAYFLLSK
>NZ_LT992456.1|WP_000840813.1|1761619_1762093_+|DUF1641-domain-containing-protein
MAERISSKIRRLEKSEEQIKLESLNEVTEAIAANKDSILKAIKLIKVLDDAKILDALNGAVRGRQVIINKFAVELNKDIYTGLLSNMASMVFLLGELNVSDLSDFLNKVNKGLHVANQASPNAKTSVRSLFGVLKDDDMNRSLTYMLNMLKGMSRED
>NZ_LT992456.1|WP_001155267.1|1758665_1761620_+|formate-dehydrogenase-subunit-alpha
MQEHLVVTLDGKDYLVEPGTNLLEFIKSQDTFVPSICYNESMGPIQTCDTCTVEIDGKIERSCSTVIDRPMTVNTVNNDVKDAQKEALDRILEKHMLYCTVCDYNNGDCEIHNTMDAWGLQHQTYEYKEKPYEKDYGPFYRYDPNQCILCGRCVEACQDIEVNETIRIDWDREHPRVIWDNDVPINESSCVSCGQCATVCPCNAMMEVNMEGNAGYMTDTEPGSLAAMIDLTKKAEPGYGPLFAISDSEAEMRKERIKKTKTVCTYCGVGCSFEVWTKDREILKVQPSHDSPANKIATCVKGKFSWGHINSDQRLTKPLVRKNGEFHEVEWDEALNVIADNFTSIKEKHGPDALSFISSSKATNEESYLMQKLARQVIGTNNVDNCSRYCQAPATKGLFRTVGHGGDSGSIEDLEKAAMSVLIGTNTAEAHPVIASRMKRAQKLFGQKIHVFDIRKHEMAERADRFYQPKPGTDLAWLSAVTKYIIDHDLHDKAFIEEWVEDFDEYYKSLETFTMAFAEEATGIPEAELIKFAEECAKAESVVICWAMGITQQDIGSDSSTAISNLLLVTGNYRRPGTGAYPLRGHNNVQGCSDMGSMPDKITGYQSIEADDIRAKFEKEYGVKLNPKAGKDNHEMVEGIHDGQIHSLYLYGEDTGIVDSNINFVQAAFEKLDFMVVQDEFLTFTATFADVVLPASPSLEKDGTFTNTERRIQRLYQALKPLGESKPDWKIFQAIANKLGFDWNYKHPSEIMDEIARLTPLYAGVSYERLEGFNSLQWPVHPDGTDEPILYLEGFNFDNGKAKLFPLSFDNYFKQDEVYDIHVNNGRLLEHFHEGNMTYQTPMLKYKVPRAFVEISPELAEDRGIHEGAEVKLISETGEAVLQVHVTDRVKGKEIYIPLNNDAMENGDLGAINLLTNSDVDQYTDTPSYKRTSCRLEVITKRGKSPLNPNNFRVNKKRHPQYSVQVQKKWERPDYVFPGNQVDK
>NZ_LT992456.1|WP_000831053.1|1757116_1758064_+|LCP-family-protein
MKRSSKSKMSLPKKIFLWVFGILVILAIVAVVYVAAKIFITGNKIHNPLDRNHSELRDKKVSLNDGDPFTIALFGVDSDADRKKKGGGERSDSIMILSINPKTKKTEIVSIPRDTRAEIVGRDTTEKIAHAYAYGGPNMAVKSLEKLMNVPIDHYATIDMDGLHNMIDSIGGVDVVSNDTFTVDGVRFTKGQQTHVNGDQALKFIRSRKEEGAGGDFGRQQRQQIVLEAMANKIASPSSITHFNSLMNEIQNNVKTDLTLGDLNTIRSNYKDANDTINKHQLSGQGGIQSDGLYYFIPSEQSKAESTKLLKDNLE
>NZ_LT992456.1|WP_000130460.1|1756186_1756984_+|inositol-monophosphatase
MTDKTLQQIDKLICSWLKQIDNVIPQLIMEMTTETKRHRFDLVTNVDKQIQQQFQQFLATHFQEHQLLAEEKSNEMITNEINHLWIMDPIDGTANLVKQQEDYCIILAYFYEGKPMLSYVYDYPHKKLYKAIRGEGAFCNGIKMEEPPSLKLEDAIISFNAQVMNLDTVQDLFDASFSYRLVGACGLDSMRVAKGQFGAHINTNPKPWDIAAQFLFAELLNLKMTTLDGKAIDHLKGAPFIISNKACHETVLKILNANGGYQKYR
>NZ_LT992456.1|WP_001030125.1|1755109_1755802_-|YafY-family-transcriptional-regulator
MNKAERQNLIITAIQQNKKMTALELAKYCNVSKRTILRDIDDLENQGVKIYAHYGKNGGYQIQQAQSKIALNLSETQLSALFLVLNESQSYSTLPYKSEINAIIKQCLSLPQTRLRKLLKRMDFYIKFDDTQHMTLPMLFSDILIYCTERNVMLVDHRVDDNIKAENVIFIGLLCKHGHWHAVIYDIAQDKTAELEIENIIDISYSFGKTIQTRDISIDNYHQFLNPIDS
>NZ_LT992456.1|WP_000426692.1|1754347_1755085_+|CPBP-family-intramembrane-metalloprotease-SdpB
MENEKKKYTFKDIAWRDLFIIPIIGVLSFALTIAAYIVPILFGYYEIDSNLIFVGTITQALAYTIGIGAFYLFHLKVMPSRLRAGFAYIKKYWLRLSITYIIALILIYTYEYMTQFLPKHLQYSETANELELNKMFEVPVFLPVAFLLIVIVGPIVEEIVFRHILIGELGKKFNFIAMSIVSVFLFAFIHVTDAKSPFEFGPYLILSIILVFTYIKSGRNLGSTIALHIANNFVSFVISVISIYA
>NZ_LT992456.1|WP_000606724.1|1753969_1754299_-|hypothetical-protein
MINETKYMRQQITNLIQIIDTIKYNTLMTDWNIQTHIYKFNQIVTNELNKFKGFETSYIINENQVFYYEIITLLNKRPLRQVDYGNKIQYLNFYHTELSNALFAIKFAH
>NZ_LT992456.1|WP_000073196.1|1752652_1753525_-|MurR/RpiR-family-transcriptional-regulator
MSNVLTEIDSQYPYMTKNEKKIAKFILNSPQKVIKMRSQDLASLLDISTSSVIRFSKKITDGGFHDLKINISKYVPKASSIYNVELMNNESTESLRTKLHTRTTRALNHANNELNDKTIDQICHCLKRSETIFIYGFGASFVVATDLYQKLSRIGLNIQLVQETHIFATLLATHNSNDSVILITNNGTQSEMQSMVKVIDDYHIPIITITSTRDNPVAQASNIVLTYGKTDENEMHMGATTSLFAQMFTIDILYYRYVALNYHASLDYITQSKMALDNYRKHLSNINFKH
>NZ_LT992456.1|WP_000684154.1|1764027_1765152_+|FAD-dependent-monooxygenase
MKIAIIGAGIGGLTAAALLQEQGHTIKVFEKNESVKEIGAGIGIGDNVLKKLGNHDLAKGIKNAGQILSTMTVLDDKDRPLTTVKLKSNTLNVTLPRQTLIDIIKSYVKDDAIFTNHEVTHIDNETDKVTIHFAEQESEAFDLCIGADGIHSKVRQSVNADSKVLYQGYTCFRGLIDDIDLKHPDCAKEYWGRKGRVGIVPLLNNQAYWFITINSKENNHKYSSFGKPHLQAYFNHYPNEVREILDKQSETGILLHNIYDLKPLKSFVYGRTILLGDAAHATTPNMGQGAGQAMEDAIVLVNCFNAYDFEKALQRYDKIRVKHTAKVIKRSRKIGKIAQYRSRLVVAVRNRIMKMMPNALAAGQTKFLYKSKEK
>NZ_LT992456.1|WP_000417008.1|1765243_1766197_-|2-hydroxyacid-dehydrogenase
MEKVYVAGAIPEVGLKLLQEHFEVEMYEGKGLVDKDTLIKGVKDATALISLLSTNVDKDVIDAGKDLKIIANYGAGFNNIDIEYAREKSIDVTNTPKASTNATADLTIGLVLAVARRIVEGDQLSRTTGFDGWAPLFFRGREVSGKTIGIIGLGEIGSAVARRARAFDMDVLYTGPNRKEEKEREIGAKYVDLDTLLKNADFITINAAYNPKMHHLIDTEQFKMMKSTAYLINASRGPIVHEQALVQALKNNEIEGAALDVYEFEPDITDDLKSLNNVVLTPHIGNATFEARDMMSKIVANAAISAVQGEKPQFVVN
>NZ_LT992456.1|WP_000737699.1|1766559_1767060_-|CHAP-domain-containing-protein
MKKLVTATTLTAGIGTALVGHAQHADAAENYTNYNNYNYNTTQTTTTTTTTTTTSSISHSGNLYTAGQCTWYVYDKVGGEIGSTWGNANNWAAAAQGAGFTVNHTPSKGAILQSSEGPFGHVAYVESVNSDGSVTISEMNYSGGPFSVSSRTISASEAGNYNYIHI
>NZ_LT992456.1|WP_000206106.1|1767296_1767719_-|DUF4870-domain-containing-protein
MTTEMNDVTNHQPNRKSNDENIMAMLIYLLSLFTSIIGPLIIWLLKKDESKLVDRAGKNYLNYTISYIIWSIVLVVITFIGVFLIATDIDFIIIIGFIITFIGILSIFAFSILSFVFTIIACVKYYNGQEYVIPLTIRFI
>NZ_LT992456.1|WP_000684571.1|1767966_1769049_+|NAD/NADP-octopine/nopaline-dehydrogenase-family-protein
MKIAIVGSGNGAVTAAVDMVSKGHDVKLYCRNQSISKFQNAIEKGGFDFNNEGEERFVKFTDISDDMEYVLKDAEIVQVIIPSSYIEYYADVMAEHVTDNQLIFFNMAAAMGSIRFMNVLEDRHIETKPQLAEANTLTYGTRVDFENAAVDLSLNVRRIFFSTYDRSCLNDCYDKVSSIYDHLVKEESLIKTNLENGNPEVHPGPTLLNVGRIDYAGEFALYKEGITKHTVRLLHAIELERLNLGRRLGFELSTAKESRIERGYLERDKEDEPLNRLFNTSPVFSQIPGPNHVESRYLTEDIAYGLVLWSSLGRVIDVPTPNIDAVIVIASTILERDFFEEGLTVESIGLDKLDLEKYLK
>NZ_LT992456.1|WP_114668444.1|1769143_1770544_+|Na+/H+-antiporter-NhaC
MMTRKPTFLESISTMIVMVIVVVTGFVFFDIPIQVLLIIASAYAAWIAKRVGLTWQDLEKGIAERLNTAMPAILIILAVGIIVGSWMFSGTVPALIYYGLDLLNPSYFLISAFFISAVTSVATGTAWGSASTAGIALISIGNQLSISPGMAAGAIIAGAVFGDKMSPLSDTTNLAALVTKVNIFKHIRSMMWTTIPASIIGLLVWFIAGFQFKGHSNDKQIQTLLSELAHIYQINIWVWVPLIVIIVCLLFKMATVPAMLISSFSAIIVGTFNHHFKMTDGFKAIFSGFNDSMIHQSHISSSVKSLLEQGGMMSMTQILVTIFCGYAFAGIVEKAGCLEVLLTTISKGIHSVGSLICITVICCIALVFAAGVASIVIIMVGVLMKDLFEKYQVSRFVLSRTLEDSSTMVLPLIPWGTSGIYYTNQLHVSVGEFFIWTVPCYLCAIIAIIYGFTGICIKKSSNSRLT
>NZ_LT992456.1|WP_001826088.1|1770717_1770912_+|hypothetical-protein
MTKLIENLKASIFVSTLTKNLSMYSRFDAPKFGCVNGCMLFILYYRVNRIGENRSFEISTNPIF
>NZ_LT992456.1|WP_000717395.1|1770980_1771790_-|CHAP-domain-containing-protein
MKKIATATIATAGFATIAIASGNQAHASEQDNYGYNPNDPTSYSYTYTIDAQGNYHYTWKGNWHPSQLNQDNGYYSYYYYNGYNNYSYNNYNNGYSYNNYSRYNNYSNNNQSYNYNNYNSYNTNSYRTGGLGASYSTSSNNVQVTTTMAPSSNGRSISSGYTSGRNLYTSGQCTYYVFDRVGGKIGSTWGNASNWANAAARAGYTVNNTPKAGAIMQTTQGAYGHVAYVESVNSNGSVRVSEMNYGYGPGVVTSRTISASQAAGYNFIH
>NZ_LT992456.1|WP_000131824.1|1772399_1774355_+|helix-turn-helix-transcriptional-regulator
MTDNYSLHIFKSMKMSSVKEANLKIIYWLQGTGVVSINLQQYDVKRNDVTVIMLNDLYQIDGHDDSVCCVVEVSAKTFLKFMNANYMMRGKILTNEVASTLRILIKYLIYSKIKQQPYNANDKIINYMCVELMSLNTYDGSRHLVAEEVHDYLTNNHHKKINRKDVINQVSITNKALSDMFKATPYSNFIQYLNHIRLEHCLIDILTSKKPIEEIASSHGFNHYSRFIHLFKETYGDTPKLIRKRNSPTSHSINHSQLVEIDKNIIELFDDTNQSSSSMREIDIPFEPTKRSQMYQPKNIYIKGSNFYWMDYYTIKQIIQRLGVNPENLHIIVTIDTSNELSIEQITLLLQKIVNYNVNVVFRIKHEYKELLTSTERGKIEKLVATIFNMTFESNRCKIAFLINDLNTTAIQKLKRLIDNYIGVFELIYHLEPNELNTRYDKEIDHLIDYFILPLRQIEQVSIARSKIICDVDLINENNDLKEKITMSDINKVTELLTNYTKFRGLIMHMSIISEASKEINLTRLSIFIFIINILNQLRGIVIYQNDTMIVTKFKHEVQCVICLPAALLNENSDAIRLSCKGLQQFSHAKTKQIVLSIDKDNHTSENGVLVNDIMQQHSYWKANFIERNIYDHSLMVSSNSIVHLKYHLEI
>NZ_LT992456.1|WP_000032840.1|1774380_1775124_+|transcriptional-regulator
MSKFKVKRLTAHILMLKVINDMLKYSFHLTLTQVKLLNLLVKYDNSDSNSASIDRLLKMKEIQSKMALLQMLSYLNNHQWLLKARDQRDQRKLTISINKMHIDKIEYMNNELSDYIERYFGQYTFDFSCDYVSYLLSSQELLLNLKCYLNMCQLSLEELYVLGILNLHKGQLTVKELQGEFHHPIFAVSPILKCLILKGLVKKERCELDERRVIVTIKREKFSKVTMLIQACYNYLEKGIQVKLNNK

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Crispr_ID: NZ_LT992456_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LT992456_8

1983048-1983260

Orphan

Consensus_repeat	Method
CATCAAAGTAGCATGGCATGACACCAAGCTTCCACAACAGCACATCA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_LT992456_8

>merge|NZ_LT992456|8|1983048-1983260|CRISPRCasFinder
CATCAAAGTAGCATGGCATGACACCAAGCTTCCACAACAGCACATCAAAGTAACATGGCACCAACACCAAGCTCCCACAACAGCACATCAAAGTAGCATGGCACGACACCAAGCTTCCACAACAGCACATCATAGCACTACATCAAGACGCATCGTGGTACCAGCACATCAAAGTAACATGTCATGACACCAAGTTCCCGCAACAATACGTCA

>NZ_LT992456|8|6|1983048-1983260|CRISPRCasFinder
CATCAAAGTAGCATGGCATGACACCAAGCTTCCACAACAGCACATCA	AAGTAACATGGCACCAACACCAAGCTCCCACAACAGCA
CATCAAAGTAGCATGGCACGACACCAAGCTTCCACAACAGCACATCA	TAGCACTACATCAAGACGCATCGTGGTACCAGCA
CATCAAAGTAACATGTCATGACACCAAGTTCCCGCAACAATACGTCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LT992456.1\|WP_001109939.1\|1986661_1987864_-\|rod-shape-determining-protein-RodA	unknown	unknown	gnl\|CDD\|274033
NZ_LT992456.1\|WP_001187614.1\|1983293_1983941_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224336
NZ_LT992456.1\|WP_001190840.1\|1993010_1993706_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_LT992456.1\|WP_000725800.1\|1980180_1981053_+\|membrane-protein-insertase-YidC	unknown	unknown	gnl\|CDD\|235040
NZ_LT992456.1\|WP_000932694.1\|1975298_1975694_+\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|366099
NZ_LT992456.1\|WP_114668447.1\|1983968_1985453_-\|cardiolipin-synthase	unknown	unknown	gnl\|CDD\|211988
NZ_LT992456.1\|WP_000447678.1\|1974167_1974608_+\|3-hydroxyacyl-ACP-dehydratase-FabZ	unknown	unknown	gnl\|CDD\|234568
NZ_LT992456.1\|WP_001108486.1\|1978660_1979452_+\|hydroxyethylthiazole-kinase	unknown	unknown	gnl\|CDD\|236477
NZ_LT992456.1\|WP_000751995.1\|1976082_1976778_+\|lytic-transglycosylase-SceD	unknown	unknown	gnl\|CDD\|369056
NZ_LT992456.1\|WP_000611457.1\|1989266_1990622_+\|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D--alanine-ligase	unknown	unknown	gnl\|CDD\|223841
NZ_LT992456.1\|WP_001178939.1\|1991137_1992658_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223587
NZ_LT992456.1\|WP_000396068.1\|1977164_1977854_+\|thiaminase-II	unknown	unknown	gnl\|CDD\|213919
NZ_LT992456.1\|WP_001825748.1\|1982693_1983014_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LT992456.1\|WP_000581792.1\|1985923_1986133_+\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|238219
NZ_LT992456.1\|WP_000138932.1\|1985618_1985912_+\|copper-sensing-transcriptional-repressor-CsoR	unknown	unknown	gnl\|CDD\|197387
NZ_LT992456.1\|WP_000828354.1\|1986260_1986398_+\|hypothetical-protein	unknown	unknown	unknown
NZ_LT992456.1\|WP_000159641.1\|1988181_1989252_+\|D-alanine--D-alanine-ligase	unknown	unknown	gnl\|CDD\|234993
NZ_LT992456.1\|WP_000594965.1\|1977846_1978677_+\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|180561
NZ_LT992456.1\|WP_000846746.1\|1974664_1975105_-\|YwpF-like-family-protein	unknown	unknown	gnl\|CDD\|379494
NZ_LT992456.1\|WP_000483161.1\|1979453_1980095_+\|thiamine-phosphate-synthase	unknown	unknown	gnl\|CDD\|234590

Protein	Function_ID	Function_description	E-value
NZ_LT992456.1\|WP_001109939.1\|1986661_1987864_-\|rod-shape-determining-protein-RodA	gnl\|CDD\|274033	TIGR02210, Rod_shape-determining_protein_RodA, rod shape-determining protein RodA. This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	3.51677e-108
NZ_LT992456.1\|WP_001190840.1\|1993010_1993706_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.28552e-68
NZ_LT992456.1\|WP_000751995.1\|1976082_1976778_+\|lytic-transglycosylase-SceD	gnl\|CDD\|369056	pfam06737, Transglycosylas, Transglycosylase-like domain. This family of proteins are very likely to act as transglycosylase enzymes related to pfam00062 and pfam01464. These other families are weakly matched by this family, and include the known active site residues.	6.44668e-24
NZ_LT992456.1\|WP_000932694.1\|1975298_1975694_+\|single-stranded-DNA-binding-protein	gnl\|CDD\|366099	pfam00436, SSB, Single-strand binding protein family. This family includes single stranded binding proteins and also the primosomal replication protein N (PriB). PriB forms a complex with PriA, PriC and ssDNA.	9.06157e-32
NZ_LT992456.1\|WP_000725800.1\|1980180_1981053_+\|membrane-protein-insertase-YidC	gnl\|CDD\|235040	PRK02463, PRK02463, OxaA-like protein precursor; Provisional.	7.06711e-64
NZ_LT992456.1\|WP_000138932.1\|1985618_1985912_+\|copper-sensing-transcriptional-repressor-CsoR	gnl\|CDD\|197387	cd10152, SaCsoR-like_DUF156, Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156. This domain family includes Staphylococcus aureus CsoR (SaCsoR). SaCsoR is Cu(I)-inducible, and regulates the expression of genes involved in copper homeostasis; it represses a genetically unlinked copA-copZ operon. copA encodes a copper efflux P-type ATPase, and copZ, a copper chaperone. This family belongs to a larger superfamily that contains various transcriptional regulators that respond to different stressors such as Cu(I), Ni(I), sulfite, and formaldehyde, and includes Mycobacterium tuberculosis CsoR (MtCsoR), Bacillus subtilis CsoR, and Thermus thermophilus CsoR. The latter three proteins do not belong to this family. CsoRs form homotetramers (dimer of dimers). In MtCsoR, within each dimer, two Cys residues on opposite subunits, along with a His residue, bind the Cu(I) ion (forming a triagonal S2N coordination complex, C-H-C). These residues are conserved in the majority of members of this superfamily, including this family, and a conserved Tyr and a Glu residue that facilitate allosteric regulation of DNA binding for CsoRs are also well conserved.	8.02331e-35
NZ_LT992456.1\|WP_000447678.1\|1974167_1974608_+\|3-hydroxyacyl-ACP-dehydratase-FabZ	gnl\|CDD\|234568	PRK00006, fabZ, 3-hydroxyacyl-ACP dehydratase FabZ.	8.27669e-92
NZ_LT992456.1\|WP_001108486.1\|1978660_1979452_+\|hydroxyethylthiazole-kinase	gnl\|CDD\|236477	PRK09355, PRK09355, hydroxyethylthiazole kinase; Validated.	7.69146e-123
NZ_LT992456.1\|WP_001187614.1\|1983293_1983941_-\|HD-domain-containing-protein	gnl\|CDD\|224336	COG1418, COG1418, Predicted HD superfamily hydrolase [General function prediction only].	2.00474e-42
NZ_LT992456.1\|WP_000611457.1\|1989266_1990622_+\|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D--alanine-ligase	gnl\|CDD\|223841	COG0770, MurF, UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane].	0
NZ_LT992456.1\|WP_001178939.1\|1991137_1992658_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	7.40342e-159
NZ_LT992456.1\|WP_000396068.1\|1977164_1977854_+\|thiaminase-II	gnl\|CDD\|213919	TIGR04306, salvage_TenA, thiaminase II. The TenA protein of Bacillus subtilis and Staphylococcus aurues, and the C-terminal region of trifunctional protein Thi20p from Saccharomyces cerevisiae, perform cleavages on thiamine and related compounds to produce 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP), a substrate a salvage pathway for thiamine biosynthesis. The gene symbol tenA, for Transcription ENhancement A, reflects a misleading early characterization as a regulatory protein. This family is related to PqqC from the PQQ biosynthesis system (see TIGR02111), heme oxygenase (pfam01126), and CADD (Chlamydia protein Associating with Death Domains), a putative folate metabolism enzyme (see TIGR04305).	1.05378e-100
NZ_LT992456.1\|WP_114668447.1\|1983968_1985453_-\|cardiolipin-synthase	gnl\|CDD\|211988	TIGR04265, bac_cardiolipin, cardiolipin synthase. This model is based on experimentally characterized bacterial cardiolipin synthases (cls) from E. coli, Staphylococcus aureus (two), and Bacillus pseudofirmus OF4. This model describes just one of several homologous but non-orthologous forms of cls. The cutoff score is set arbitrarily high to avoid false-positives. Note that there are two enzymatic activites called cardiolipin synthase. This model represents type 1, which does not rely on a CDP-linked donor, but instead does a reversible transfer of a phosphatidyl group from one phosphatidylglycerol molecule to another.	0
NZ_LT992456.1\|WP_000581792.1\|1985923_1986133_+\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|238219	cd00371, HMA, Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.	0.000383249
NZ_LT992456.1\|WP_000159641.1\|1988181_1989252_+\|D-alanine--D-alanine-ligase	gnl\|CDD\|234993	PRK01966, ddl, D-alanine--D-alanine ligase.	0
NZ_LT992456.1\|WP_000594965.1\|1977846_1978677_+\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl\|CDD\|180561	PRK06427, PRK06427, bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed.	1.38659e-148
NZ_LT992456.1\|WP_000846746.1\|1974664_1975105_-\|YwpF-like-family-protein	gnl\|CDD\|379494	pfam14183, YwpF, YwpF-like protein. The YwpF-like protein family includes the B. subtilis YwpF protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 146 and 167 amino acids in length. There is a conserved IIN sequence motif.	1.15589e-56
NZ_LT992456.1\|WP_000483161.1\|1979453_1980095_+\|thiamine-phosphate-synthase	gnl\|CDD\|234590	PRK00043, thiE, thiamine phosphate synthase.	5.71532e-89

>NZ_LT992456.1|WP_001825748.1|1982693_1983014_-|hypothetical-protein
MIWRCGVMGGIARGIDAMPLQFYDMALGRCNVYYAVVTLLFHTVTCICELLWKCCDIYCYTDESLCQDDIAMMNSNSVINHFLHAEISLILFGSMSNWTDAFNIGS
>NZ_LT992456.1|WP_000725800.1|1980180_1981053_+|membrane-protein-insertase-YidC
MKKKALLPLFLGIMVFLAGCDYSKPEKRSGFFYNTFVDPMKNVLDWLGNNLLNDNYGLAIIILVLVIRIILLPFMLSNYKNSHMMRQKMKVAKPEVEKIQEKVKRARTQEEKMAANQELMQVYKKYDMNPIKSMLGCLPMLIQLPIIMGLYFVLKDQLVDGLFKYPHFLWFDLGRPDIWITIIAGVLYFIQAYVSSKTMPDEQRQMGYMMMVISPIMIIWISLSSASALGLYWSVSAAFLVVQTHFANIYYEKVAKKEVQPFIEAYEREHNGGNNKKGKNTQVVSKKKKK
>NZ_LT992456.1|WP_000483161.1|1979453_1980095_+|thiamine-phosphate-synthase
MFNQSYLNVYFICGTSDVPSHRTIHEVLEAALKAGITLFQFREKGESALKGNDKLVLAKELQHLCHQYDVPFIVNDDVSLAKEINADGIHVGQDDAKVKEIAQYFTDKIIGLSISDLGEYAKSDLTHVDYIGVGPIYPTPSKNDAHTPVGPEMIATFKEMNPQLPIVAIGGINTSNVAPIVEAGANGISVISAISKSENIEKTVNRFKDFFNN
>NZ_LT992456.1|WP_001108486.1|1978660_1979452_+|hydroxyethylthiazole-kinase
MNYLNKIRIENPLTICYTNDVVKNFTANGLLSIGASPAMSEAPEEAEEFYKVAQALLINIGTLTAQNEQDIIAIAQTANEAGLPIVFDPVAVGASTYRKQFCKLLLKSAKVSVIKGNASEILALIDDTATMKGTDSDANLDAVAIAKKAYAIYKTAIVITGKEDVIVQGDKAIVLANGSPLLARVTGAGCLLGGVIAGFLFRETEPDIEALIEAVSVFNIAAEVAAENENCGGPGTFSPLLLDTLYHLNETTYQQRIRIQEVE
>NZ_LT992456.1|WP_000594965.1|1977846_1978677_+|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MIKPKIALTIAGTDPTGGAGVMADLKSFHSCGVYGMGVVTSIVAQNTLGVQNIHNLNHQWVDEQLDSVFNDTLPHAIKTGMIATADTMETIRHYLMQHESIPYVIDPVMLAKSGDSLMDNDTKQNLQHTLLPLADVVTPNLPEAEEITGLTIDSEEKIMQAGRIFINEIGSKGVIVKGGHSNDTDIAKDYLFTKEGVQTFENERFKTKHTHGTGCTFSAVITAELAKGRPLFDAVQKAKKFISMSIQYTPEIGRGRGPVNHFAYLKKEGLDDELSK
>NZ_LT992456.1|WP_000396068.1|1977164_1977854_+|thiaminase-II
MEFSQKLYQAAKPIINDIYEDDFIQKMLLGNIQADALRHYLQADAAYLKEFTNLYALLIPKMNSMNDVKFLVEQIEFMVEGEVLAHDILAQIVGESYEEIIKTKVWPPSGDHYIKHMYFQAHSRENAIYTIAAMAPCPYIYAELAKRSQSDHKLNREKDTAKWFDFYSTEMDDIINVFESLMNKLAESMSDKELEQVKQVFLESCIHERRFFNMAMTLEQWEFGGKVND
>NZ_LT992456.1|WP_000751995.1|1976082_1976778_+|lytic-transglycosylase-SceD
MKKTLLASSLAVGLGIVAGNAGHEAHASEADLNKASLAQMAQSNDQTLNQKPIEAGAYNYTFDYEGFTYHFESDGTHFAWNYHATGANGADMSAQAPATNNVAPSADQANQVQSQEVEAPQNAQTQQPQASTSNNSQVTATPTESKASEGSSVNVNDHLKQIAQRESGGNIHAVNPTSGAAGKYQFLQSTWDSVAPAKYKGVSPANAPESVQDAAAVKLYNTGGAGHWVTA
>NZ_LT992456.1|WP_000932694.1|1975298_1975694_+|single-stranded-DNA-binding-protein
MLNKIVIVGRLTKDAQIFEKEDRKIATFCVATHRNYKDENGEIVCDYLFCKAFGKLASNIEKYTNQGTLVGITGQMRSRKYDKDGQTHFVTELYVETIKFMSPKSQNNEILSDSILDIDSQNIDNHDLLEI
>NZ_LT992456.1|WP_000846746.1|1974664_1975105_-|YwpF-like-family-protein
MKTFKAVRFQIVNEHGRIIEYELEDGVIINKEESGTGWLLEIVISNEHYETFKEYQDNEQLLDIRVVITRPANDPALFESTVKSIKNFKTTMSIVFECHIYTLRQQYAESLLEQLIDDGLSGEELKKSFNRMMQSKPKLKDEKLEE
>NZ_LT992456.1|WP_000447678.1|1974167_1974608_+|3-hydroxyacyl-ACP-dehydratase-FabZ
METIFDYNQIKQIIPHRQPFLLIDKVVEYEEGQRCVAIKQVSGNEPFFQGHFPEYAVMPGVLITEALAQTGAVAILNSEENKGKIALFAGIDKCRFKRQVVPGDTLTLEVEITKIKGPIGKGNAKATVDGQLACSCELTFAIQDVK
>NZ_LT992456.1|WP_001187614.1|1983293_1983941_-|HD-domain-containing-protein
MQQSDIISAAKKYMESIHQNDYTGHDIAHVYRVTALAKSIAENEGVNDTLVIELACLLHDTVDEKVVDANKQYAELKSFLSSLSLSTEDQEHILFIINNMSYRNGKNDHVTLTLEGQIVRDADRLDAIGAIGVARTFQFAGHFGEPMWTEQMSLDKINDDLVEQLPPSAIKHFFEKLLKLESLMHTDTAKMIAKERHDFMMIYLKQFFTEWNYHD
>NZ_LT992456.1|WP_114668447.1|1983968_1985453_-|cardiolipin-synthase
MIELLSIALKHSNIILNSIFIGAFILNLLFAFTIIFMERRSANSIWAWLLVLVFLPLFGFILYLLLGRQIQRDQIFKIDKEDKKGLELIVDEQLAALKNENFSNSNYQIVKFKEMIQMLLYNNAAFLTTDNDLKIYTDGQEKFDDLIQDIRNATDYIHFQYYIIQNDELGRTILNELGKKAEQGVEVKILYDDMGSRGLRKKGLRPFRNKGGHAEAFFPSKLPLINLRMNNRNHRKIVVIDGQIGYVGGFNVGDEYLGKSKKFGYWRDTHLRIVGDAVNALQLRFILDWNSQATRDHISYDDRYFPDVNSGGTIGVQIASSGPDEEWEQIKYGYLKMISSAKKSIYIQSPYFIPDQAFLDSIKIAALGGVDVNIMIPNKPDHPFVFWATLKNAASLLDAGVKVFHYDNGFLHSKTLVIDDEIASVGTANMDHRSFTLNFEVNAFIYDQQITKKLKQAFIDDLAVSSELTKARYANRSLWIKFKEGISQLLSPIL
>NZ_LT992456.1|WP_000138932.1|1985618_1985912_+|copper-sensing-transcriptional-repressor-CsoR
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQEEAMEELLVTFQKLIKD
>NZ_LT992456.1|WP_000581792.1|1985923_1986133_+|heavy-metal-associated-domain-containing-protein
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF
>NZ_LT992456.1|WP_000828354.1|1986260_1986398_+|hypothetical-protein
MKRPEKIQNVVKLLSSLGVNIKKTKSRLDIINTLPASNKVSHELK
>NZ_LT992456.1|WP_001109939.1|1986661_1987864_-|rod-shape-determining-protein-RodA
MNYSSRQQPDKHWLRKVDWVLVATIAVLAIFSVLLINSAMGGGQYSANFGIRQIFYYILGAIFAGIIMFISPKKIKHYTYLLYFLICLLLIGLLVIPESPITPIINGAKSWYTFGPISIQPSEFMKIILILALARVVSRHNQFTFNKSFQSDLLLFFKIIGVSLVPSILILLQNDLGTTLVLAAIIAGVMLVSGITWRILAPIFITGIVGAMTVILGILYAPALIENLLGVQLYQMGRINSWLDPYTYSSGDGYHLTESLKAIGSGQLLGKGYNHGEVYIPENHTDFIFSVIGEELGFIGSVILILIFLFLIFHLIRLAAKIEDQFNKIFIVGFVTLLVFHILQNIGMTIQLLPITGIPLPFISYGGSALWSMMTGIGIVLSIYYHEPKRYVDLYHPKSN
>NZ_LT992456.1|WP_000159641.1|1988181_1989252_+|D-alanine--D-alanine-ligase
MTKENICIVFGGKSAEHEVSILTAQNVLNAIDKDKYHVDIIYITNDGDWRKQNNITTEIKSTDELHLENGEALEISQLLKESSSGQPYDAVFPLLHGPNGEDGTIQGLFEVLDVPYVGNGVLSAASSMDKLVMKQLFEHRGLPQLPYISFLRSEYEKYEHNILKLVNDKLNYPVFVKPANLGSSVGISKCNNEAELKEGIKEAFQFDRKLVIEQGVNAREIEVAVLGNDYPEATWPGEVVKDVAFYDYKSKYKDGKVQLQIPADLDEDVQLTLRNMALEAFKATDCSGLVRADFFVTEDNQIYINETNAMPGFTAFSMYPKLWENMGLSYPELITKLIELAKERHQDKQKNKYKID
>NZ_LT992456.1|WP_000611457.1|1989266_1990622_+|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D--alanine-ligase
MINVTLKQIQSWIPCEIEDQFLNQEINGVTIDSRAISKNMLFIPFKGENVDGHRFVSKALQDGAGAAFYQKGTPIDENVSGPIIWVEDTLTALQQLAQAYLRHVNPKVIAVTGSNGKTTTKDMIESVLHTEFKVKKTQGNYNNEIGLPLTILELDNDTEISILEMGMSGFHEIEFLSNLAQPDIAVITNIGESHMQDLGSREGIAKAKSEITIGLKDNGTFIYDGDEPLLKPHVKEVENAKCISIGVATDNALVCSVDDRDTTGISFTINNEHYDLPILGKHNMKNATIAIAVGHELGLTYNIIYQNLKNVSLTGMRMEQHTLENDITVINDAYNASPTSMRAAIDTLSTLTGRRILILGDVLELGENSKEMHIGVGNYLEEKHIDVLYTFGNEAKYIYDSGQQHVEKAQHFNSKDDMIEVLTSDLKAHDRVLVKGSRGMKLEEVVNALIS
>NZ_LT992456.1|WP_001178939.1|1991137_1992658_+|DEAD/DEAH-box-helicase
MQNFKELGISDNTVQSLESMGFKEPTPIQKDSIPYALQGIDILGQAQTGTGKTGAFGIPLIEKVVGKQGVQSLILAPTRELAMQVAEQLREFSRGQGVQVVTVFGGMPIERQIKALKKGPQIVVGTPGRVIDHLNRRTLKTDGIHTLILDEADEMMNMGFIDDMRFIMDKIPAVQRQTMLFSATMPKAIQALVQQFMKSPKIIKTMNNEMSDPQIEEFYTIVKELEKFDTFTNFLDVHQPELAIVFGRTKRRVDELTSALISKGYKAEGLHGDITQAKRLEVLKKFKNDQINILVATDVAARGLDISGVSHVYNFDIPQDTESYTHRIGRTGRAGKEGIAVTFVNPIEMDYIRQIEDANGRKMSALRPPHRKEVLQAREDDIKEKVENWMSKDSESRLKRISTELLNEYNDVDLVAALLQELVEANDEVEVQLTFEKPLSRKGRNGKPSGSRNRNSKRGNPKFDSKSKRSKGYSSKKKSTKKFDRKEKSSGGSRPMKGRTFADHQK
>NZ_LT992456.1|WP_001190840.1|1993010_1993706_-|response-regulator-transcription-factor
MQSKILIIEDDHAITHLLDVALTLDYYNVTTADNATQAHFKIQIDKPDVILLDLGLPDKDGLCLISEIRQHTDIPIIVISARQEEQTIIQALDNGANDYMTKPFNVDELRARIRVIERIAKSHQETNFVFTNGLLSIDFGSKSVVINNQEVHLTPNEFSLLELLSNHKGKVLTYEMILKRIYGYVNKTEMPSLRVHMTSLRQKLSQCHEDAKDIIKTHPRIGYQMLQWKEK

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Crispr_ID: NZ_LT992456_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LT992456_9

2354741-2354823

Orphan

Consensus_repeat	Method
GTAAGCTGACTTTTTCGTCAGCTTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_LT992456_9

>merge|NZ_LT992456|9|2354741-2354823|CRISPRCasFinder
GTAAGCTGACTTTTTCGTCAGCTTCTGTGTTGGGGCCCACCCCAACTTGCACATTATAGTAAGCTGACTTTTTCGTCAGCTTC

>NZ_LT992456|9|7|2354741-2354823|CRISPRCasFinder
GTAAGCTGACTTTTTCGTCAGCTTC	TGTGTTGGGGCCCACCCCAACTTGCACATTATA
GTAAGCTGACTTTTTCGTCAGCTTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LT992456.1\|WP_000634175.1\|2350648_2351149_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_LT992456.1\|WP_000471571.1\|2363466_2364324_+\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	unknown	unknown	gnl\|CDD\|235547
NZ_LT992456.1\|WP_000690004.1\|2351289_2352408_+\|alanine-dehydrogenase	unknown	unknown	gnl\|CDD\|240630
NZ_LT992456.1\|WP_000777188.1\|2353953_2354643_+\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|234811
NZ_LT992456.1\|WP_000717561.1\|2365536_2366505_+\|6-phosphofructokinase	unknown	unknown	gnl\|CDD\|235111
NZ_LT992456.1\|WP_000226933.1\|2358396_2361594_+\|DNA-polymerase-III-subunit-alpha	unknown	unknown	gnl\|CDD\|223660
NZ_LT992456.1\|WP_000160430.1\|2355766_2357065_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|226594
NZ_LT992456.1\|WP_000883646.1\|2364323_2365268_+\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	unknown	unknown	gnl\|CDD\|235580
NZ_LT992456.1\|WP_000872673.1\|2345412_2346636_+\|tRNA-4-thiouridine(8)-synthase-ThiI	unknown	unknown	gnl\|CDD\|234960
NZ_LT992456.1\|WP_000040067.1\|2349199_2350402_+\|acetate-kinase	unknown	unknown	gnl\|CDD\|234680
NZ_LT992456.1\|WP_000365308.1\|2346679_2347450_+\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|182593
NZ_LT992456.1\|WP_000840583.1\|2348164_2349112_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|223897
NZ_LT992456.1\|WP_001232654.1\|2366526_2368284_+\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|235784
NZ_LT992456.1\|WP_000058389.1\|2362042_2363272_+\|NAD-dependent-malic-enzyme-4	unknown	unknown	gnl\|CDD\|235976
NZ_LT992456.1\|WP_000161656.1\|2352723_2353779_-\|aminopeptidase-P-family-protein	unknown	unknown	gnl\|CDD\|223085
NZ_LT992456.1\|WP_000277602.1\|2355148_2355562_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_LT992456.1\|WP_000136251.1\|2347547_2348042_+\|thiol-peroxidase	unknown	unknown	gnl\|CDD\|179055
NZ_LT992456.1\|WP_000818532.1\|2368627_2369989_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NZ_LT992456.1\|WP_000626092.1\|2357434_2358376_+\|pApA-hydrolase-Pde2	unknown	unknown	gnl\|CDD\|223691
NZ_LT992456.1\|WP_072434776.1\|2344264_2345413_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029

Protein	Function_ID	Function_description	E-value
NZ_LT992456.1\|WP_000634175.1\|2350648_2351149_-\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	9.27306e-36
NZ_LT992456.1\|WP_000471571.1\|2363466_2364324_+\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	gnl\|CDD\|235547	PRK05654, PRK05654, acetyl-CoA carboxylase carboxyltransferase subunit beta.	0
NZ_LT992456.1\|WP_000690004.1\|2351289_2352408_+\|alanine-dehydrogenase	gnl\|CDD\|240630	cd05305, L-AlaDH, Alanine dehydrogenase NAD-binding and catalytic domains. Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.	0
NZ_LT992456.1\|WP_000777188.1\|2353953_2354643_+\|metal-dependent-hydrolase	gnl\|CDD\|234811	PRK00685, PRK00685, metal-dependent hydrolase; Provisional.	3.09103e-133
NZ_LT992456.1\|WP_000717561.1\|2365536_2366505_+\|6-phosphofructokinase	gnl\|CDD\|235111	PRK03202, PRK03202, ATP-dependent 6-phosphofructokinase.	0
NZ_LT992456.1\|WP_000226933.1\|2358396_2361594_+\|DNA-polymerase-III-subunit-alpha	gnl\|CDD\|223660	COG0587, DnaE, DNA polymerase III, alpha subunit [DNA replication, recombination, and repair].	0
NZ_LT992456.1\|WP_000160430.1\|2355766_2357065_+\|CBS-domain-containing-protein	gnl\|CDD\|226594	COG4109, COG4109, Predicted transcriptional regulator containing CBS domains [Transcription].	0
NZ_LT992456.1\|WP_000883646.1\|2364323_2365268_+\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	gnl\|CDD\|235580	PRK05724, PRK05724, acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated.	0
NZ_LT992456.1\|WP_000872673.1\|2345412_2346636_+\|tRNA-4-thiouridine(8)-synthase-ThiI	gnl\|CDD\|234960	PRK01565, PRK01565, thiamine biosynthesis protein ThiI; Provisional.	0
NZ_LT992456.1\|WP_000040067.1\|2349199_2350402_+\|acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NZ_LT992456.1\|WP_000365308.1\|2346679_2347450_+\|TSUP-family-transporter	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	1.0657e-38
NZ_LT992456.1\|WP_000840583.1\|2348164_2349112_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|223897	COG0827, COG0827, Adenine-specific DNA methylase [DNA replication, recombination, and repair].	6.63876e-57
NZ_LT992456.1\|WP_001232654.1\|2366526_2368284_+\|pyruvate-kinase	gnl\|CDD\|235784	PRK06354, PRK06354, pyruvate kinase; Provisional.	0
NZ_LT992456.1\|WP_000058389.1\|2362042_2363272_+\|NAD-dependent-malic-enzyme-4	gnl\|CDD\|235976	PRK07232, PRK07232, bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed.	0
NZ_LT992456.1\|WP_000161656.1\|2352723_2353779_-\|aminopeptidase-P-family-protein	gnl\|CDD\|223085	COG0006, PepP, Xaa-Pro aminopeptidase [Amino acid transport and metabolism].	1.16164e-126
NZ_LT992456.1\|WP_000277602.1\|2355148_2355562_-\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	6.00154e-19
NZ_LT992456.1\|WP_000136251.1\|2347547_2348042_+\|thiol-peroxidase	gnl\|CDD\|179055	PRK00522, tpx, thiol peroxidase.	7.99696e-100
NZ_LT992456.1\|WP_000818532.1\|2368627_2369989_-\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	0
NZ_LT992456.1\|WP_000626092.1\|2357434_2358376_+\|pApA-hydrolase-Pde2	gnl\|CDD\|223691	COG0618, COG0618, Exopolyphosphatase-related proteins [General function prediction only].	5.72376e-100
NZ_LT992456.1\|WP_072434776.1\|2344264_2345413_+\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	1.21752e-165

>NZ_LT992456.1|WP_000777188.1|2353953_2354643_+|metal-dependent-hydrolase
MKLSFHGQSTIYLEGNNKKVIVDPFISNNPKCDLNIETVQVDYIVLTHGHFDHFGDVVELAKKTGATVIGSAEMADYLSSYHGVENVHGMNIGGKANFDFGSVKFVQAFHSSSFTHENGIPVYLGMPMGIVFEVEGKTIYHTGDTGLFSDMSLIAKRHPVDVCFVPIGDNFTMGIDDASYAINEFIKPKISVPIHYDTFPLIEQDPQQFKDAVNVGDVQILKPGESVQF
>NZ_LT992456.1|WP_000161656.1|2352723_2353779_-|aminopeptidase-P-family-protein
MTKISKIIDELNNQQADAAWITTPLNVYYFTGYRSEPHERLFALLIKKDGKQVLFCPKMEVEEVKASPFTGEIVGYLDTENPFSLYPQTINKLLIESEHLTVARQKQLISGFNVNSFGDVDLTIKQLRNIKSEDEINKIRKAAELADKCIEIGVSYLKEGVTEREVVNHIEQTIKQYGVNEMSFDTMVLFGDHAASPHGTPGDRRLKSNEYVLFDLGVIYEHYCSDMTRTIKFGEPSQEAQEIYNIVLEAETSAIQAIKPGIPLKDIDHIARNIISEKGYGEYFPHRLGHGLGLQEHEYQDVSSTNSNLLEAGMVITIEPGIYVPGVAGVRIEDDILVTNEGYEVLTHYEK
>NZ_LT992456.1|WP_000690004.1|2351289_2352408_+|alanine-dehydrogenase
MKIGIPREIKNNENRVGLSPSGVHALVESGHTVLVETNAGSGSFFEDVDYKEAGAEIVAEQAKVWDVDMVIKVKEPLESEYPYFKEGLVLFTYLHLANEEKLTQALIDRKVISIAYETVQLPDRSLPLLSPMSEVAGRMSAQVGAEFLQKLNGGMGILLGGVPGVPKGKVTIIGGGQAGTNAAKIALGLGADVTILDVNPKRLQQLDDLFGGRVHTIMSNPLNIELYVKQSDLVIGAVLIPGAKAPRLVTEDMIKQMKNGSVIIDIAIDQGGIFETTDKITTHDNPTYIKHGVVHYAVANMPGAVPRTSTLALNNATLPYALMLANKGYREAFKSNQPLSLGLNTYKGHVTNKGVAEAFEMEYKSVEEALQL
>NZ_LT992456.1|WP_000634175.1|2350648_2351149_-|universal-stress-protein
MITYKNILIAVDGSHEAEWAFNRAVGVAKRNDAKLTIVNVIDSRTYSSYEVYDAQFTEKSKHFAEELLNGYKEVATNAGVKDVETRLEFGSPKSIIPKKLAHEINADLIMSGTSGLNAVERFIVGSVSESIVRHAPCDVLVVRTEELPADFQPQVATTQLREKYQN
>NZ_LT992456.1|WP_000040067.1|2349199_2350402_+|acetate-kinase
MSKLILAINAGSSSLKFQLIRMPEEELVTKGLVERIGLKDSIFTIEVDGEKVKTVQDIKDHVEAVDIMLDAFKKHNIINDINDIDGTGHRVVHGGEKFPESAAITDEVEKEIEELSELAPLHNPANLMGIRAFRKLLPNIPHVAIFDTAFHQTMPEKAYLYSLPYHYYKDYGIRKYGFHGTSHKFVSQRAAEMLDKPIEDLRIISCHIGNGASIAAIDGGKSIDTSMGFTPLAGVTMGTRSGNIDPALIPFIMEKTGKTAEQVLEILNKESGLLGLSGTSSDLRDLSEEAESGKARSQMALDVFASKIHKYIGSYAARMHGVDVIVFTAGIGENSVEIRAKVLEGLEFMGVYWDPKKNENLQRGKEGFINYPHSPVKVVVIPTDEESMIARDVMTYGGLK
>NZ_LT992456.1|WP_000840583.1|2348164_2349112_+|class-I-SAM-dependent-methyltransferase
MAEQQTIMERLFHTLDEKAKTLNNENGQSFIENLGLAMEQVYTNERGLLEQSTLQDRRKAFQFAYLSLMQEEKIQANHQITPDSIGLILGFLVERFMNNQEELHIVDIASGAGHLSATVKEVLPEIAVMHHLIEVDPVLSRVSVHLANFLEIPFDVYPQDAIMPLPLEEADIVIGDFPVGYYPIDERSRDFKLGFEEGHSYSHYLLIEQAINALKDAGYAFLVVPSNIFTGEHVKQLEKYIATETEMQAFLNLPPTLFKNEKARKSILILQKKKSGETKPVEVLLANIPDFKNPSQFQGFMTELNQWMDTNRPKK
>NZ_LT992456.1|WP_000136251.1|2347547_2348042_+|thiol-peroxidase
MTEITFKGGPIHLKGQLINEGDFAPDFTVLDNDLNQVTLADYAGKKKLISVVPSIDTGVCDQQTRKFNSEASKEEGIVLTISADLPFAQKRWCASAGLDNVITLSDHRDLSFGENYGVVMEELRLLARAVFVLDADNKVVYKEIVSEGTDFPDFDAALAAYKNI
>NZ_LT992456.1|WP_000365308.1|2346679_2347450_+|TSUP-family-transporter
MDLNLTMIIIIILFGFIAAFIDSVVGGGGLISTPALLAIGLPPSVALGTNKLASSFGSLTSAIKFIRSGKVDLYVVAKLFGFVFLASACGAYIATMVPSQILKPLIIIALSSVFIFTLLKKDWGNTRTFTQFTFKKAILFAALFILIGFYDGFVGGGTGSFMLFVLLIFGFDFLSAAGNAKVLNFASNIGALVLFMVLGQVDYVIGLVMAASMIVGSYAGAHFAIKQGVGYVKVLFIIITAILILKNAFDYIQQFV
>NZ_LT992456.1|WP_000872673.1|2345412_2346636_+|tRNA-4-thiouridine(8)-synthase-ThiI
MKYDHLLVRYGELTLKGSNRKKFVNQLRNNVNKSLKGLDGFVVKGKRDRMYIELEDHADINEITYRLSKIFGIKSISPVLKVEKTLEAMSATAIKFAQQFEENSTFKIDVKRADKNYPMDTYELQRELGGAVLKHFDNISVNVKRPDHEIRVEVRLDAIYMYEEVVQGAGGLPVGTGGKTLLMLSGGIDSPVAGMEVMRRGVTIEAIHFHSPPFTSDQAKEKVIELTRILAERVGPIKLHIVPFTELQKQVNKVVHPRYTMTSTRRMMMRVADKLVHQIGAYAIVNGENLGQVASQTLHSMYAINNVTSTPVLRPLLTYDKEEIIIKSKEIGTFETSIQPFEDCCTIFTPKNPVTEPNFDKVVQYESVFDFEEMINRAVENIETLEITSDYKTIKEQQTNQLINDFL
>NZ_LT992456.1|WP_072434776.1|2344264_2345413_+|cysteine-desulfurase
MFILIYLDNAATTKAFEEVLDTYLKVNQSMYYNPNSPHKAGLQADQLLQQAKVQINDMVNTNMTYDVVFTSGATESNNIALKGVAYRKFDTAREIITSVLEHPSVLEVVRYLEEREGFKVKYVDVTKDGSINLEHFKELMSDKVGLVTCMYVNNVTGQIQPIPQMADVIKNYPKAHFHVDAVQAFGKISMDFNNVDSISLSGHKFNGLKGQGVLLVNHIQNVEPTVHGGGQEYGVRSGTVNLPNDIAMVKAMKIANENLEALNAFVTELNNDVRQFLNKYHGVYINSSTSGSPFVLNVSFPGVKGEVLVNAFSKYDIMISTTSACSSKRNKLNEVLTAMGLSDKAIEGSIRLSFGAMTTKEDITKFKETFTIIYEEIKELLK
>NZ_LT992456.1|WP_000277602.1|2355148_2355562_-|universal-stress-protein
MYKNILLGVDTQLKNEKALKEVSKLAGEGTVVTVLNAISEQDAQASIKAGVHLNKLTEERSKRLEKTRKALEDYGIDYDQIIVRGNAKEELLKHANSGKYEIVVLSNRKAEDKKKFVLGSVSHKVAKRATIPVLIVK
>NZ_LT992456.1|WP_000160430.1|2355766_2357065_+|CBS-domain-containing-protein
MTKHEQILDYIESLSIGSKISVRKIAKFLNVSEGTAYRAIKDADKMGMVATIDRVGTVRIEKRNRNEIEHLTFNEIVNIIDGQVLGGNKGITKMVSKFAIGAMELKDILKYIGPKTLLIVGNREDVQIEALKRGTAILITGGFKPSNKVIDFANEHDLPVLSSSYDTFLVANIINKALFNQKIRKDILIVQDIMTPLDDLSVLFDTMKIADYKRMANQTGHTRFPVVNESYKLVGIVTSREMINTKDDDEIDKVMTRNPIYVNAMSTVASCAHMMIWEGIELIPVVSSNKKTVGVINRQDVLKSMQLLGRQPQMGETINDQIAKYITMNQDGITVEVSPLLINHYGTVSKAAFVSIIEETIQYEMRKFKKGNVMIENLNIVYIKTVPIESHITVRFGILDVGRNFAKIEVNMHSQNDKVASALVICQMFDEV
>NZ_LT992456.1|WP_000626092.1|2357434_2358376_+|pApA-hydrolase-Pde2
MISTMNEIMKCIEDNDTIIIHRHVRPDPDAYGSQLGLKYYIQQKFPQKQVFAVGEAESSLSFIGELDNIDDKTYQDALVIVCDTANAPRIDDERYSTGRKLIKIDHHPAVDQYGDINLVNTNASSTSEIIYDLISHFNDEAIVNKDIASVLYLGIVGDTGRFLFNNTSEHTMEIAGKLIGHDIDHNALLNKMMEKDPKMLPFQGYVLQHFELMDDGFCQVKITEDVLKQFGIQPNEASQFVNTIADIKGLKIWVFAVDEGSEIRCRLRSKGQLIINDIAQDFGGGGHPNASGVSVNSWDEFEQLAKALRTKLN
>NZ_LT992456.1|WP_000226933.1|2358396_2361594_+|DNA-polymerase-III-subunit-alpha
MVAYLNIHTAYDLLNSSLKIEDAVRLAVSENVDALAITDTNVLYGFPKFYDTCIANNIKPIFGMTIYVTNGLNTVETVVLAKDNNGLKDLYQLSSEIKMNALEHVSFELLKRFSNNMIIIFKNVADEHRDIVQVFDSHEDTYLDHRSVLVQGIKHVWIQDVCYQTRHDADTISALAAIRDNTKLDLIHDQEDFGAHFLTENEIQQLDVNPEYFTQADRIAQKCDAELKYHQSLLPQYQAPNDESAKKYLWRVLVTQLKKLELNYDVYLERLKYEYKVITNMGFEDYFLIVSDLIHYAKTNDVMVGPGRGSSAGSLVSYLLGITTIDPIKFNLLFERFLNPERVTMPDIDIDFEDTRREKVIQYVQEKYGELHVSGIVTFGHLLARAVARDVGRIMGFDEVTLNEISSLIPHKLGITLDEAYQIDDFKKFVHRNHRHERWFSICKKLEGLPRHTSTHAAGIIINDHPLYEYAPLTKGDTGLLTQWTMTEAERIGLLKIDFLGLRNLSIIHQILTQVKKDLGINIDIEKIPFDDQKVFELLSQGDTTGIFQLESDGVRSVLKKLKPEHFEDIVAVTSLYRPGPMEEIPTYITRRHDPSKVQYLHPHLEPILKNTYGVIIYQEQIMQIASTFANFSYGEADILRRAMSKKNRAVLESERQHFIEGAKQNGYHEDISKQIFDLILKFADYGFPRAHAVSYSKIAYIMSFLKVHYPNYFYANILSNVIGSEKKTAQMIEEAKKQGITILPPNINESHWFYKPSQEGIYLSIGTIKGVGYQSVKVIVEERYQNGKFKDFFDFARRIPKRVKTRKLLEALILVGAFDAFGKTRSTLLQAIDQVLDGDLNIEQDGFLFDILTPKQMYEDKEELPDALISQYEKEYLGFYVSQHPVDKKFVAKQYLTIFKLSNAQNNKPILVQFDKVKQIRTKNGQNMAFVTLNDGIETLDGVIFPNQFKKYEELLSHNDLFIVSGKFDLRKQQRQLIINEIQTLATFEEQKLAFAKQIIIRNKSQIDMFEEMIKATKENANDVVLSFYDETIKQMTTLGYINQKDSMFNNFIQSFNPSDIRLI
>NZ_LT992456.1|WP_000058389.1|2362042_2363272_+|NAD-dependent-malic-enzyme-4
MSLRDEALEMHKRNQGKLEVKPNVKVTNKEELSLAYSPGVAEPCKDIYEDKRKVYDYTIKGNTVAVITDGTAVLGLGNIGPEASIPVMEGKAVLFKSFAGINGVPIALNTTDTEEIIKTVKLLEPNYGGINLEDISAPRCFEIEERLKKETNIPVFHDDQHGTAIVTMAGLVNALRVVNKDIAKIKVVLNGAGAAGIAIVKLLYAYGVRNMVMCDSRGAIFEGRSYGMNPTKDVVAKWTNKDKIEGSLEEVVKDADVFIGVSVANALSQDMVKSMADNPIIFAMANPNPEIIPDDAKAAGARVVGTGRSDYPNQINNVLAFPGIFRGALEVEATHINEEMKKAAVEAIADLIDSSELNEDYCIPGPFDKRVAPSVARNVAKAAMESGVARIEVDPQDVYDKTMKLTDLQ
>NZ_LT992456.1|WP_000471571.1|2363466_2364324_+|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta
MFKDFFNRTKKKKYLTVQDSKNNDVPAGIMTKCPKCKKIMYTKELAENLNVCFNCDHHIALTAYKRIEAISDEGSFTEFDKGMTSANPLDFPSYLEKIEKDQQKTGLKEAVVTGTAQLDGMKFGVAVMDSRFRMGSMGSVIGEKICRIIDYCTENRLPFILFSASGGARMQEGIISLMQMGKTSVSLKRHSDAGLLYISYLTHPTTGGVSASFASVGDINLSEPKALIGFAGRRVIEQTINEKLPDDFQTAEFLLEHGQLDKVVHRNDMRQTLSEILKIHQEVTK
>NZ_LT992456.1|WP_000883646.1|2364323_2365268_+|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha
MLDFEKPLFEIRNKIESLKESQDKNDVDLQEEIDMLEASLERETKKIYTNLKPWDRVQIARLQERPTTLDYIPYIFDSFMELHGDRNFRDDPAMIGGIGFLNGRAVTVIGQQRGKDTKDNIYRNFGMAHPEGYRKALRLMKQAEKFNRPIFTFIDTKGAYPGKAAEERGQSESIATNLIEMASLKVPVIAIVIGEGGSGGALGIGIANKVLMLENSTYSVISPEGAAALLWKDSNLAKIAAETMKITAHDIKQLGIIDDVISEPLGGAHKDIEQQALAIKSAFVEQLDSLESLSRDEIANDRFEKFRNIGSYIE
>NZ_LT992456.1|WP_000717561.1|2365536_2366505_+|6-phosphofructokinase
MKKIAVLTSGGDSPGMNAAVRAVVRTAIYNEIEVYGVYHGYQGLLNDDIHKLELGSVGDTIQRGGTFLYSARCPEFKEQEVRKVAIENLRKRGIEGLVVIGGDGSYRGAQRISEECKEIQTIGIPGTIDNDINGTDFTIGFDTALNTIIGLVDKIRDTASSHARTFIIEAMGRDCGDLALWAGLSVGAETIVVPEVKTDIKEIADKIEQGIKRGKKHSIVLVAEGCMTAQDCQKELSQYINVDNRVSVLGHVQRGGSPTGADRVLASRLGGYAVDLLMQGETAKGVGIKNNKIVATSFDEIFDGKDHKFDYSLYELANKLSI
>NZ_LT992456.1|WP_001232654.1|2366526_2368284_+|pyruvate-kinase
MRKTKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAILLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEGTPEKFSVTYENLINDVQVGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNKKGVNLPGVRVSLPGITEKDAEDIRFGIKENVDFIAASFVRRPSDVLEIREILEEQKANISVFPKIENQEGIDNIEEILEVSDGLMVARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVETSLVNAIGISVAHTALNLNVKAIVAATESGSTARTISKYRPHSDIIAVTPSEETARQCSIVWGVQPVVKKGRKSTDALLNNAVATAVETGRVTNGDLIIITAGVPTGETGTTNMMKIHLVGDEIANGQGIGRGSVVGTTLVAETVKDLEGKDLSDKVIVTNSIDETFVPYVEKALGLITEENGITSPSAIVGLEKGIPTVVGVEKAVKNISNNMLVTIDAAQGKIFEGYANVL
>NZ_LT992456.1|WP_000818532.1|2368627_2369989_-|amino-acid-permease
MAEKLQRELSNRHIQLIAIGGAIGTGLFLGAGQTIALTGPSILLTYIIIGFMLFMFMRGLGEIIIQNTEFKSFADVTNTYIGPFAGFVTGWTYWFCWIITGMAEVTAVAKYVSFWFPEIPNWISALFCVLLLMSFNLLSARLFGELEFWFSIIKIATIIGLIVVGFVMILFAYKTQFGHASFTNLYEHGVFPKGASGFFMSFQMALFSFVGIEMIGVTAGETKDPVKTIPKAINSVPIRILIFYVGALAVIMSIIPWQQVDPDNSPFVKLFALIGIPFAAGLINFVVLTAAASSCNSGIFSNSRMLFGLSSQQQAPPNFSKTNKYGVPHVAIFASSALLLVAALLNYIFPDATKVFTYVTTISTVLFLVVWGLIIIAYINYSRKNPDLHKKATYKLFGGKYMGYLIFVFFIFVFGLLFINVETRRAIYFIPIWFILLGFMYLRYKRIAAKSNN

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_LT992456_7	7.1\|1763602\|26\|NZ_LT992456\|CRISPRCasFinder	1763602-1763627	26	NZ_LT992456.1	2477253-2477278	0	1.0
NZ_LT992456_7	7.1\|1763602\|26\|NZ_LT992456\|CRISPRCasFinder	1763602-1763627	26	NZ_LT992456.1	439540-439565	1	0.962
NZ_LT992456_1	1.1\|435167\|31\|NZ_LT992456\|CRISPRCasFinder	435167-435197	31	NZ_LT992456.1	490119-490149	2	0.935
NZ_LT992456_6	6.1\|1631725\|33\|NZ_LT992456\|CRISPRCasFinder	1631725-1631757	33	NZ_LT992456.1	1014558-1014590	2	0.939
NZ_LT992456_7	7.1\|1763602\|26\|NZ_LT992456\|CRISPRCasFinder	1763602-1763627	26	NZ_LT992456.1	390460-390485	2	0.923
NZ_LT992456_7	7.1\|1763602\|26\|NZ_LT992456\|CRISPRCasFinder	1763602-1763627	26	NZ_LT992456.1	435395-435420	2	0.923
NZ_LT992456_7	7.1\|1763602\|26\|NZ_LT992456\|CRISPRCasFinder	1763602-1763627	26	NZ_LT992456.1	1972124-1972149	2	0.923
NZ_LT992456_7	7.1\|1763602\|26\|NZ_LT992456\|CRISPRCasFinder	1763602-1763627	26	NZ_LT992456.1	2793628-2793653	2	0.923

1. spacer 7.1|1763602|26|NZ_LT992456|CRISPRCasFinder matches to position: 2477253-2477278, mismatch: 0, identity: 1.0

ccgccagcttctatgttggggccccg	CRISPR spacer
ccgccagcttctatgttggggccccg	Protospacer
**************************

2. spacer 7.1|1763602|26|NZ_LT992456|CRISPRCasFinder matches to position: 439540-439565, mismatch: 1, identity: 0.962

ccgccagcttctatgttggggccccg	CRISPR spacer
ccgtcagcttctatgttggggccccg	Protospacer
***.**********************

3. spacer 1.1|435167|31|NZ_LT992456|CRISPRCasFinder matches to position: 490119-490149, mismatch: 2, identity: 0.935

atcacttatgctttattatgtattggttctt	CRISPR spacer
atcactaatgatttattatgtattggttctt	Protospacer
****** *** ********************

4. spacer 6.1|1631725|33|NZ_LT992456|CRISPRCasFinder matches to position: 1014558-1014590, mismatch: 2, identity: 0.939

cagtagctggcggaaagtcagcttacaataatg	CRISPR spacer
cagaagctggcgaaaagtcagcttacaataatg	Protospacer
*** ********.********************

5. spacer 7.1|1763602|26|NZ_LT992456|CRISPRCasFinder matches to position: 390460-390485, mismatch: 2, identity: 0.923

ccgccagcttctatgttggggccccg	CRISPR spacer
ccaccagcttctgtgttggggccccg	Protospacer
**.*********.*************

6. spacer 7.1|1763602|26|NZ_LT992456|CRISPRCasFinder matches to position: 435395-435420, mismatch: 2, identity: 0.923

ccgccagcttctatgttggggccccg	CRISPR spacer
ccgcctgctactatgttggggccccg	Protospacer
***** *** ****************

7. spacer 7.1|1763602|26|NZ_LT992456|CRISPRCasFinder matches to position: 1972124-1972149, mismatch: 2, identity: 0.923

ccgccagcttctatgttggggccccg	CRISPR spacer
ccgccagcttttgtgttggggccccg	Protospacer
**********.*.*************

8. spacer 7.1|1763602|26|NZ_LT992456|CRISPRCasFinder matches to position: 2793628-2793653, mismatch: 2, identity: 0.923

ccgccagcttctatgttggggccccg	CRISPR spacer
ccgccagtttctgtgttggggccccg	Protospacer
*******.****.*************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_LT992456_8	8.2\|1983180\|34\|NZ_LT992456\|CRISPRCasFinder	1983180-1983213	34	NC_027332	Acinetobacter phage YMC13/03/R2096, complete genome	68639-68672	11	0.676
NZ_LT992456_8	8.2\|1983180\|34\|NZ_LT992456\|CRISPRCasFinder	1983180-1983213	34	KY000079	Acinetobacter phage AM24, complete genome	74925-74958	11	0.676

1. spacer 8.2|1983180|34|NZ_LT992456|CRISPRCasFinder matches to NC_027332 (Acinetobacter phage YMC13/03/R2096, complete genome) position: , mismatch: 11, identity: 0.676

tagcactacatcaagacgcatcgtggtaccagca	CRISPR spacer
ttctaccacttcaagacgcatcgtggtattgatc	Protospacer
*  .**.** ******************.....

2. spacer 8.2|1983180|34|NZ_LT992456|CRISPRCasFinder matches to KY000079 (Acinetobacter phage AM24, complete genome) position: , mismatch: 11, identity: 0.676

tagcactacatcaagacgcatcgtggtaccagca	CRISPR spacer
ttctaccacttcaagacgcatcgtggtattgatc	Protospacer
*  .**.** ******************.....

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

248523 : 256996

Synechococcus_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000238668.1\|248523_249090_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	2.7e-29	40.1
WP_000030815.1\|249092_250121_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	2.9e-61	41.1
WP_000483707.1\|250113_251598_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	8.5e-46	31.7
WP_000032750.1\|251576_253766_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.3e-140	39.4
WP_000666799.1\|253758_254430_-	phosphoribosylformylglycinamidine synthase I	NA	NA	NA	NA
WP_000848351.1\|254431_254695_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_000174055.1\|254694_255399_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	2.1e-47	42.1
WP_001010409.1\|255402_256527_-	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_001807816.1\|256513_256996_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	6.2e-22	44.7

DBSCAN-SWA_2

276779 : 301247

Planktothrix_phage(50.0%)

holin,protease,bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001088778.1\|276779_277961_+\|protease	cysteine protease staphopain B	NA	NA	NA	NA
WP_000284455.1\|277998_278328_+	staphostatin B	NA	NA	NA	NA
WP_000184947.1\|278565_279387_-	1,4-dihydroxy-2-naphthoyl-CoA synthase	NA	NA	NA	NA
WP_000150215.1\|279379_280183_-	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase	NA	NA	NA	NA
WP_000526673.1\|280169_281843_-	2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase	NA	NA	NA	NA
WP_000190616.1\|281829_283191_-	isochorismate synthase MenF	NA	NA	NA	NA
WP_000070966.1\|283372_284311_+	1,4-dihydroxy-2-naphthoate polyprenyltransferase	NA	NA	NA	NA
WP_000620945.1\|284361_284913_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_000867362.1\|285077_285293_+	TM2 domain-containing protein	NA	NA	NA	NA
WP_001794249.1\|285356_285488_+	hypothetical protein	NA	NA	NA	NA
WP_001081332.1\|285536_286496_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000766009.1\|286986_287343_+	DoxX family protein	NA	NA	NA	NA
WP_157958947.1\|287431_287620_-	poly(glycerol-phosphate) alpha-glucosyltransferase	NA	NA	NA	NA
WP_001796515.1\|287709_288000_+	hypothetical protein	NA	NA	NA	NA
WP_000571192.1\|288087_288729_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.0e-19	33.7
WP_000668623.1\|288725_289046_-	YxeA family protein	NA	NA	NA	NA
WP_000870811.1\|289048_291013_-\|bacteriocin	bacteriocin-associated integral membrane family protein	NA	NA	NA	NA
WP_000790905.1\|291056_291341_-\|bacteriocin	lactococcin 972 family bacteriocin	NA	NA	NA	NA
WP_099119695.1\|291975_292053_-\|holin	putative holin-like toxin	NA	NA	NA	NA
WP_001033867.1\|292352_292955_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_000214898.1\|292969_293146_-	YkvS family protein	NA	NA	NA	NA
WP_000668814.1\|293344_294331_+	lipoate--protein ligase	NA	NA	NA	NA
WP_000876826.1\|294411_294630_-	IDEAL domain-containing protein	NA	NA	NA	NA
WP_000287260.1\|294839_295409_+	competence protein ComK	NA	NA	NA	NA
WP_000414168.1\|295897_297409_-	bifunctional metallophosphatase/5'-nucleotidase	NA	NA	NA	NA
WP_000021872.1\|297547_298906_-	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_014937014.1\|298922_301247_-\|protease	serine protease	W5SAB9	Pithovirus	2.1e-11	27.4

DBSCAN-SWA_3

355717 : 378942

Streptococcus_phage(94.74%)

integrase

attL 351426:351443|attR 390469:390486

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
351426:351443	attL	NA	NA	NA	NA
WP_000420682.1\|355717_356032_+	YdcP family protein	A0A1S5SF38	Streptococcus_phage	5.2e-54	100.0
WP_000985015.1\|356047_356434_+	YdcP family protein	A0A1S5SF96	Streptococcus_phage	3.0e-64	100.0
WP_000813488.1\|356462_357848_+	DNA translocase FtsK	A0A1S5SFB5	Streptococcus_phage	1.1e-265	100.0
WP_000879507.1\|357850_358003_+	hypothetical protein	NA	NA	NA	NA
WP_000398286.1\|358025_359231_+	replication initiation factor domain-containing protein	A0A1S5SEX3	Streptococcus_phage	1.1e-232	99.8
WP_001009056.1\|359273_359495_+	hypothetical protein	A0A1S5SEY0	Streptococcus_phage	4.3e-31	100.0
WP_000342539.1\|359611_360109_+	antirestriction protein ArdA	A0A1S5SF25	Streptococcus_phage	1.7e-91	100.0
WP_000506270.1\|360083_360590_+	conjugal transfer protein	A0A1S5SEX7	Streptococcus_phage	8.6e-91	100.0
WP_000331163.1\|360573_363021_+	ATP-binding protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	99.9
WP_000804748.1\|363023_365201_+	membrane protein	A0A1S5SF30	Streptococcus_phage	0.0e+00	100.0
WP_000769868.1\|365197_366199_+	lysozyme family protein	A0A1S5SEZ8	Streptococcus_phage	5.0e-191	100.0
WP_001224318.1\|366195_367128_+	conjugal transfer protein	A0A1S5SF22	Streptococcus_phage	3.1e-171	99.4
WP_001814923.1\|367372_367489_+	tetracycline resistance determinant leader peptide	NA	NA	NA	NA
WP_000691736.1\|367504_369424_+	tetracycline resistance ribosomal protection protein Tet(M)	A0A1S5SF82	Streptococcus_phage	0.0e+00	99.5
WP_000336323.1\|369542_369710_+	cysteine-rich KTR domain-containing protein	D0R0F6	Streptococcus_phage	1.6e-14	68.0
WP_001227347.1\|369769_370123_-	helix-turn-helix domain-containing protein	A0A1S5SFA6	Streptococcus_phage	1.3e-58	100.0
WP_000804885.1\|370627_371050_+	sigma-70 family RNA polymerase sigma factor	A0A1S5SEW0	Streptococcus_phage	2.5e-72	100.0
WP_000857133.1\|371046_371277_+	helix-turn-helix domain-containing protein	A0A1S5SEX1	Streptococcus_phage	2.7e-36	100.0
WP_000814511.1\|371737_371941_+	excisionase	A0A1S5SF07	Streptococcus_phage	4.0e-31	100.0
WP_001291561.1\|372022_373240_+\|integrase	tyrosine-type recombinase/integrase	A0A1S5SEW7	Streptococcus_phage	3.7e-233	100.0
WP_000902814.1\|373504_373894_-	YisL family protein	NA	NA	NA	NA
WP_000670757.1\|374220_375123_-	fumarylacetoacetate hydrolase family protein	NA	NA	NA	NA
WP_000154905.1\|375288_378942_-	helicase-exonuclease AddAB subunit AddA	A7KV33	Bacillus_phage	7.0e-25	24.7
390469:390486	attR	NA	NA	NA	NA

DBSCAN-SWA_4

518591 : 532907

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000616865.1\|518591_519353_-	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	7.2e-17	30.1
WP_001245567.1\|519349_520306_-	iron chelate uptake ABC transporter family permease subunit	A0A2H4J116	uncultured_Caudovirales_phage	1.6e-05	57.8
WP_000876311.1\|520292_521264_-	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	7.8e-141	80.2
WP_000562498.1\|521633_522605_-	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
WP_000855505.1\|522724_524830_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
WP_000692521.1\|524792_525191_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	1.2e-52	72.0
WP_001068490.1\|525992_526859_+	DMT family transporter	NA	NA	NA	NA
WP_000930016.1\|526878_527379_+	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	2.7e-52	66.2
WP_000193750.1\|527718_529224_+	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
WP_014936998.1\|529295_529403_-	hypothetical protein	NA	NA	NA	NA
WP_000429003.1\|529493_530411_+	diacylglycerol kinase family lipid kinase	A0A1V0SBJ0	Catovirus	2.8e-07	22.0
WP_000197271.1\|531147_531690_-	5'-3'-deoxyribonucleotidase	NA	NA	NA	NA
WP_000663034.1\|531848_532907_-	histidinol-phosphate transaminase	A0A0H3TLT9	Faustovirus	1.5e-20	26.9

DBSCAN-SWA_5

544876 : 552696

Pandoravirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001217786.1\|544876_546028_-	anthranilate synthase component I family protein	S4VNU7	Pandoravirus	2.1e-23	36.1
WP_000604516.1\|546011_546605_-	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	3.1e-39	44.0
WP_000446724.1\|546955_547624_+	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.5
WP_000941336.1\|547625_548045_+	6-carboxytetrahydropterin synthase QueD	S4U060	uncultured_phage	6.3e-07	28.7
WP_001062967.1\|548048_548762_+	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	5.0e-52	43.5
WP_000637685.1\|548860_549445_+	hypothetical protein	NA	NA	NA	NA
WP_001093559.1\|549725_550166_+	DM13 domain-containing protein	NA	NA	NA	NA
WP_001037805.1\|550506_550980_+	DoxX family protein	NA	NA	NA	NA
WP_000149344.1\|550954_551641_+	response regulator transcription factor	NA	NA	NA	NA
WP_000244415.1\|551640_552696_+	two-component system sensor histidine kinase SaeS	A0A1V0SGX0	Hokovirus	3.6e-14	29.8

DBSCAN-SWA_6

884086 : 895791

Staphylococcus_phage(30.0%)

integrase

attL 878831:878851|attR 892750:892770

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
878831:878851	attL	NA	NA	NA	NA
WP_031905601.1\|884086_884578_-	pathogenicity island protein	A0A2H4JB26	uncultured_Caudovirales_phage	2.3e-24	41.1
WP_031905600.1\|884762_885821_-	hypothetical protein	NA	NA	NA	NA
WP_000884055.1\|885807_886014_-	hypothetical protein	NA	NA	NA	NA
WP_001081426.1\|886238_886583_-	hypothetical protein	A0A1W6JQD5	Staphylococcus_phage	5.5e-41	65.2
WP_031905599.1\|887255_889628_-	DNA primase	A0A2H4JCU9	uncultured_Caudovirales_phage	8.0e-147	41.2
WP_031867740.1\|889719_890019_-	DUF1474 family protein	Q4ZE75	Staphylococcus_phage	4.6e-36	76.8
WP_001058503.1\|890019_890244_-	hypothetical protein	A0A1W6JPA6	Staphylococcus_phage	3.0e-16	61.8
WP_162852058.1\|890236_890383_-	hypothetical protein	NA	NA	NA	NA
WP_000080597.1\|890429_890690_-	hypothetical protein	NA	NA	NA	NA
WP_031905598.1\|890686_890926_-	helix-turn-helix transcriptional regulator	Q38329	Lactococcus_phage	2.3e-09	41.4
WP_031588064.1\|891058_891445_+	helix-turn-helix transcriptional regulator	U3PIS7	Lactobacillus_phage	3.8e-06	41.2
WP_031905597.1\|891528_892665_+\|integrase	site-specific integrase	A0A1S5S7K9	Streptococcus_phage	3.9e-75	42.2
WP_000424968.1\|892758_894300_-	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	1.2e-23	32.6
892750:892770	attR	NA	NA	NA	NA
WP_000264071.1\|894324_895791_-	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	5.2e-96	40.5

DBSCAN-SWA_7

2051789 : 2122804

Staphylococcus_phage(94.37%)

capsid,integrase,head,terminase,holin,transposase,protease,portal,tail

attL 2063156:2063173|attR 2131559:2131576

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000197638.1\|2051789_2052533_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_000917289.1\|2052707_2052992_+	co-chaperone GroES	A0A221S386	uncultured_virus	4.7e-14	46.2
WP_000240642.1\|2053067_2054684_+	chaperonin GroEL	A0A240F779	uncultured_virus	3.4e-157	54.7
WP_000201398.1\|2055224_2055404_+	hypothetical protein	NA	NA	NA	NA
WP_000216896.1\|2055400_2056027_+	hypothetical protein	C8CH40	Staphylococcus_phage	2.4e-42	44.5
WP_001045074.1\|2056565_2057873_-	potassium transporter KtrB	NA	NA	NA	NA
WP_000206618.1\|2058255_2059479_-	ArgE/DapE family deacylase	NA	NA	NA	NA
WP_000791397.1\|2059910_2060966_+	leukocidin/hemolysin toxin family protein	A0A2I6PER8	Staphylococcus_phage	8.7e-37	35.4
WP_000595612.1\|2060987_2062004_+	leukocidin/hemolysin toxin family protein	A0A2I6PER8	Staphylococcus_phage	1.1e-25	29.3
WP_000857191.1\|2063146_2064184_-\|integrase	site-specific integrase	A0EWV2	Staphylococcus_phage	9.1e-180	100.0
2063156:2063173	attL	NA	NA	NA	NA
WP_000825947.1\|2064242_2064707_-	hypothetical protein	A0EWV3	Staphylococcus_phage	1.1e-28	100.0
WP_000705248.1\|2064806_2064989_-	hypothetical protein	M9NSW6	Staphylococcus_phage	4.1e-27	100.0
WP_000591749.1\|2065192_2065534_-	hypothetical protein	A0A2I6PF04	Staphylococcus_phage	4.6e-56	100.0
WP_000759682.1\|2065539_2066472_-	ATP-dependent helicase	A0A2I6PEZ7	Staphylococcus_phage	5.7e-173	100.0
WP_001031454.1\|2066487_2067201_-	helix-turn-helix transcriptional regulator	M9NUL0	Staphylococcus_phage	1.2e-130	100.0
WP_001801500.1\|2067163_2067337_+	hypothetical protein	NA	NA	NA	NA
WP_000854073.1\|2067333_2067597_+	helix-turn-helix transcriptional regulator	A0A2I6PF09	Staphylococcus_phage	2.1e-40	98.9
WP_001025404.1\|2067612_2067828_+	DUF2829 domain-containing protein	A0A0H3U4C7	Staphylococcus_phage	4.8e-35	100.0
WP_000128907.1\|2067816_2068146_-	hypothetical protein	M9NS98	Staphylococcus_phage	2.7e-53	100.0
WP_001148605.1\|2068196_2068949_+	phage antirepressor KilAC domain-containing protein	M9NTH5	Staphylococcus_phage	1.1e-139	100.0
WP_001148862.1\|2068964_2069162_+	hypothetical protein	O80075	Staphylococcus_phage	3.5e-24	87.7
WP_000762519.1\|2069148_2069529_-	DUF2513 domain-containing protein	Q9T1Z5	Staphylococcus_phage	3.4e-68	99.2
WP_001120201.1\|2069583_2069907_+	DUF771 domain-containing protein	A0A075LYF5	Staphylococcus_phage	3.0e-57	100.0
WP_000048129.1\|2069903_2070065_+	DUF1270 family protein	A0A1P8L6G0	Staphylococcus_phage	1.9e-20	100.0
WP_000165371.1\|2070159_2070462_+	DUF2482 family protein	A0A1P8L6F8	Staphylococcus_phage	7.0e-48	100.0
WP_000291510.1\|2070466_2070727_+	DUF1108 family protein	A0A1P8L6F5	Staphylococcus_phage	5.2e-44	100.0
WP_001205732.1\|2070735_2070999_+	hypothetical protein	A0A2I6PDG2	Staphylococcus_phage	7.7e-43	100.0
WP_000700555.1\|2071007_2072951_+	AAA family ATPase	S4V9K6	Staphylococcus_phage	0.0e+00	100.0
WP_000138475.1\|2072952_2073873_+	recombinase RecT	A0A2I6PDH5	Staphylococcus_phage	2.3e-166	100.0
WP_114668451.1\|2073953_2074571_+	MBL fold metallo-hydrolase	A0A2I6PDI9	Staphylococcus_phage	4.5e-86	99.4
WP_000610648.1\|2074571_2075042_+	single-stranded DNA-binding protein	A0EWX3	Staphylococcus_phage	1.3e-80	98.7
WP_000148321.1\|2075071_2075965_+	DnaD domain-containing protein	A0A2I6PDG7	Staphylococcus_phage	5.5e-141	99.3
WP_000338530.1\|2075971_2076190_+	hypothetical protein	A0A2I6PDG4	Staphylococcus_phage	1.0e-37	100.0
WP_000401960.1\|2076198_2076603_+	RusA family crossover junction endodeoxyribonuclease	A0EWX6	Staphylococcus_phage	1.9e-72	100.0
WP_000101288.1\|2076615_2076984_+	hypothetical protein	A0A0H3U2T3	Staphylococcus_phage	2.0e-49	100.0
WP_000131370.1\|2076987_2077230_+	hypothetical protein	Q4ZDP7	Staphylococcus_virus	2.1e-39	95.0
WP_001065097.1\|2077244_2077499_+	DUF1024 family protein	A0A0H3U469	Staphylococcus_phage	5.0e-39	100.0
WP_000714403.1\|2077485_2077656_+	hypothetical protein	A0A0H3U4U6	Staphylococcus_phage	8.2e-22	100.0
WP_001066447.1\|2077648_2078185_+	dUTP diphosphatase	A0A0H3U2Z8	Staphylococcus_phage	7.2e-96	100.0
WP_001282074.1\|2078221_2078467_+	hypothetical protein	A0A2I6PDW7	Staphylococcus_phage	5.0e-36	100.0
WP_000195803.1\|2078463_2078670_+	DUF1381 domain-containing protein	A0A0H3U2R7	Staphylococcus_phage	1.3e-29	100.0
WP_000592207.1\|2078666_2079053_+	hypothetical protein	W5R986	Staphylococcus_phage	3.0e-64	100.0
WP_000595265.1\|2079049_2079199_+	transcriptional activator RinB	A0A1W6JPZ2	Staphylococcus_phage	4.8e-18	100.0
WP_001622114.1\|2079198_2079399_+	DUF1514 family protein	A0A2I6PDV9	Staphylococcus_phage	4.0e-28	98.5
WP_000590122.1\|2079426_2079843_+	hypothetical protein	G4KNP7	Staphylococcus_phage	1.3e-76	100.0
WP_000988336.1\|2080074_2080374_+	HNH endonuclease	A0EWY8	Staphylococcus_phage	4.6e-52	100.0
WP_000402904.1\|2080504_2080849_+	hypothetical protein	G4KNP9	Staphylococcus_phage	9.4e-57	100.0
WP_000625088.1\|2080845_2082507_+\|terminase	terminase large subunit	A0A2I6PDJ8	Staphylococcus_phage	0.0e+00	100.0
WP_000025274.1\|2082522_2083710_+\|portal	phage portal protein	A0A2I6PDI1	Staphylococcus_phage	1.0e-219	100.0
WP_000642728.1\|2083693_2084431_+\|protease	Clp protease ClpP	G4KNQ2	Staphylococcus_phage	1.8e-129	100.0
WP_000154559.1\|2084454_2085600_+\|capsid	phage major capsid protein	G4KNQ3	Staphylococcus_phage	9.6e-215	100.0
WP_000238236.1\|2085619_2085904_+	hypothetical protein	A0A2I6PDJ3	Staphylococcus_phage	1.8e-45	100.0
WP_000150936.1\|2085893_2086178_+\|head,tail	phage head-tail adapter protein	A0A2I6PDJ5	Staphylococcus_phage	2.3e-45	100.0
WP_000755150.1\|2086161_2086524_+\|head,tail	head-tail adaptor protein	G4KNQ4	Staphylococcus_phage	4.4e-65	100.0
WP_000114227.1\|2086520_2086925_+	HK97 gp10 family phage protein	G4KNQ5	Staphylococcus_phage	2.1e-68	99.3
WP_000565498.1\|2086921_2087329_+	hypothetical protein	G4KNQ6	Staphylococcus_phage	7.1e-72	100.0
WP_000268733.1\|2087329_2087974_+\|tail	phage tail protein	A0A1X9H0J2	Staphylococcus_phage	1.5e-119	100.0
WP_071621395.1\|2088015_2088240_+	Ig-like domain-containing protein	A0A075LYE8	Staphylococcus_phage	3.0e-32	100.0
WP_001096355.1\|2088289_2088640_+	hypothetical protein	G4KNQ8	Staphylococcus_phage	7.8e-59	100.0
WP_001549167.1\|2088690_2088828_+	hypothetical protein	A0A2I6PDX7	Staphylococcus_phage	3.4e-18	100.0
WP_001796452.1\|2088884_2093414_+\|tail	phage tail tape measure protein	A0A2I6PDK2	Staphylococcus_phage	0.0e+00	99.8
WP_000567408.1\|2093410_2094895_+\|tail	phage tail family protein	A0A2I6PDJ0	Staphylococcus_phage	1.2e-297	100.0
WP_000582165.1\|2094910_2098696_+	hypothetical protein	A0A1X9H0H3	Staphylococcus_phage	0.0e+00	98.5
WP_001153681.1\|2098685_2098838_+	hypothetical protein	D2JLG0	Staphylococcus_phage	5.2e-20	100.0
WP_001040261.1\|2098884_2099172_+	hypothetical protein	D2JLG1	Staphylococcus_phage	1.3e-43	100.0
WP_000539688.1\|2099229_2099526_+	DUF2951 domain-containing protein	D2JLG2	Staphylococcus_phage	2.9e-46	100.0
WP_011447039.1\|2099675_2099852_+\|holin	putative holin-like toxin	D2JLG3	Staphylococcus_phage	2.2e-22	98.3
WP_001791821.1\|2099904_2100012_-	hypothetical protein	NA	NA	NA	NA
WP_000611512.1\|2100063_2100318_+\|holin	phage holin	D2JLG4	Staphylococcus_phage	4.1e-41	100.0
WP_064131634.1\|2100329_2101085_+	CHAP domain-containing protein	D2JLG5	Staphylococcus_phage	5.8e-152	99.6
WP_000919350.1\|2101275_2101767_+	staphylokinase	A0A1X9H028	Staphylococcus_phage	9.5e-87	100.0
WP_000702263.1\|2103981_2104332_+	complement inhibitor SCIN-A	A0A1P8L6B0	Staphylococcus_phage	7.5e-54	100.0
WP_001791826.1\|2104384_2104645_-	hypothetical protein	M9NS66	Staphylococcus_phage	2.3e-23	100.0
WP_000669789.1\|2104955_2105135_-	hypothetical protein	A0A1W6JQ29	Staphylococcus_phage	2.2e-25	100.0
WP_000669725.1\|2106092_2108162_+	extracellular adherence protein Eap/Map	NA	NA	NA	NA
WP_001068535.1\|2108432_2109719_-	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_000990056.1\|2109918_2110017_+	hypothetical protein	NA	NA	NA	NA
WP_000681966.1\|2110258_2110435_+	hypothetical protein	NA	NA	NA	NA
WP_000691584.1\|2110692_2111073_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_000991294.1\|2111069_2111966_+	phenol-soluble modulin export ABC transporter ATP-binding protein PmtA	A0A2H4PQG7	Staphylococcus_phage	6.5e-17	30.7
WP_000645735.1\|2111966_2112647_+	phenol-soluble modulin export ABC transporter permease subunit PmtB	NA	NA	NA	NA
WP_000763048.1\|2112643_2113516_+	phenol-soluble modulin export ABC transporter ATP-binding protein PmtC	A0A2H4PQG7	Staphylococcus_phage	6.1e-28	35.2
WP_001221650.1\|2113515_2114256_+	phenol-soluble modulin export ABC transporter permease subunit PmtD	NA	NA	NA	NA
WP_000182842.1\|2114319_2114883_-	thioredoxin family protein	NA	NA	NA	NA
WP_000966291.1\|2115003_2115528_+	membrane protein	NA	NA	NA	NA
WP_001033968.1\|2115587_2116145_+	DUF1700 domain-containing protein	NA	NA	NA	NA
WP_000713062.1\|2116141_2116984_+	DUF4097 family beta strand repeat protein	NA	NA	NA	NA
WP_001188070.1\|2117040_2118081_-	linear amide C-N hydrolase	NA	NA	NA	NA
WP_000267034.1\|2118531_2118705_+	hypothetical protein	NA	NA	NA	NA
WP_000706213.1\|2119251_2120364_+\|integrase	tyrosine-type recombinase/integrase	P97010	Streptococcus_pyogenes_phage	1.7e-11	31.6
WP_000026850.1\|2120366_2122430_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_000410574.1\|2122438_2122804_+\|transposase	transposase	NA	NA	NA	NA
2131559:2131576	attR	NA	NA	NA	NA

DBSCAN-SWA_8

2247419 : 2295166

Staphylococcus_phage(91.89%)

transposase,protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000196442.1\|2247419_2247701_+\|transposase	IS3 family transposase	A0A0C5AJ30	Paenibacillus_phage	3.2e-23	63.4
WP_000070813.1\|2248149_2248533_+	hypothetical protein	NA	NA	NA	NA
WP_000375476.1\|2248543_2248720_+	hypothetical protein	NA	NA	NA	NA
WP_000864133.1\|2249090_2249648_+	ImmA/IrrE family metallo-endopeptidase	A0A2H4PQN8	Staphylococcus_phage	1.1e-78	98.1
WP_000414230.1\|2249845_2250418_-	hypothetical protein	A0A2H4PQN4	Staphylococcus_phage	3.5e-24	93.1
WP_000627549.1\|2250515_2250860_-	DUF3969 family protein	A0A2H4PQN6	Staphylococcus_phage	5.1e-55	96.5
WP_000669036.1\|2250900_2251527_-	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	9.9e-81	84.1
WP_000070644.1\|2251602_2252598_-	DUF4352 domain-containing protein	A0A2H4PQN2	Staphylococcus_phage	1.3e-69	94.8
WP_001825423.1\|2252678_2253341_-	excalibur calcium-binding domain-containing protein	A0A2H4PQM8	Staphylococcus_phage	2.8e-49	87.7
WP_016187363.1\|2253643_2254099_+	DUF4909 domain-containing protein	A0A2H4PQN7	Staphylococcus_phage	8.3e-77	96.6
WP_000348381.1\|2254257_2255736_+	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	6.7e-277	95.5
WP_000778553.1\|2255740_2256742_+	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	3.3e-163	86.5
WP_000718107.1\|2256738_2256996_-	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
WP_000672013.1\|2257061_2257535_+	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	7.2e-84	98.7
WP_016187361.1\|2257539_2258286_+	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	7.8e-141	98.0
WP_000109913.1\|2258582_2260175_-	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	99.6
WP_000933822.1\|2260546_2261740_+	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	1.9e-218	99.7
WP_000366160.1\|2261864_2262773_+	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	1.3e-137	99.3
WP_000453302.1\|2262984_2263818_+	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	1.7e-157	98.9
WP_000623484.1\|2264067_2264421_-	CrcB family protein	A0A2H4PQQ7	Staphylococcus_phage	2.3e-18	82.1
WP_001200546.1\|2264417_2264783_-	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	6.9e-58	98.3
WP_000091443.1\|2265037_2265340_-	hypothetical protein	NA	NA	NA	NA
WP_001096494.1\|2265598_2266312_+	transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
WP_000492903.1\|2266767_2267388_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_001168915.1\|2267554_2268190_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_001030474.1\|2268487_2268931_+	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	1.4e-49	77.9
WP_001153741.1\|2268917_2269361_-	competence protein ComK	NA	NA	NA	NA
WP_000671058.1\|2269473_2269944_-	RNA polymerase sigma factor	A0A2H4PQT5	Staphylococcus_phage	5.0e-69	84.6
WP_000384171.1\|2270142_2270367_+	hypothetical protein	NA	NA	NA	NA
WP_001032832.1\|2270642_2271497_+	glucosaminidase domain-containing protein	Q4ZCC7	Staphylococcus_virus	9.8e-39	38.6
WP_000989103.1\|2271583_2272876_-	arsenite efflux transporter membrane subunit ArsB	A0A2H4PQU3	Staphylococcus_phage	7.5e-216	94.7
WP_000221190.1\|2272875_2273190_-	winged helix-turn-helix transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	1.3e-52	98.1
WP_001261672.1\|2273840_2275343_+	FAD/NAD(P)-binding protein	A0A2H4PQX2	Staphylococcus_phage	5.0e-30	98.6
WP_000077346.1\|2275823_2276867_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	3.1e-196	99.1
WP_000493892.1\|2276873_2277506_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.7e-112	99.5
WP_001159034.1\|2277516_2278698_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	1.9e-226	99.7
WP_001008555.1\|2278710_2279169_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	4.1e-68	97.4
WP_001196354.1\|2279296_2280298_-	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	9.0e-185	99.7
WP_014937042.1\|2280409_2280529_+	hypothetical protein	NA	NA	NA	NA
WP_000266096.1\|2280531_2281359_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_000757543.1\|2281931_2282333_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_000764426.1\|2282451_2283015_-	class I SAM-dependent methyltransferase	A0A2H4PQV0	Staphylococcus_phage	7.3e-99	95.7
WP_000526541.1\|2283011_2283965_-	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	6.4e-79	99.3
WP_001025064.1\|2284074_2285256_+	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	9.6e-218	99.7
WP_001807819.1\|2285543_2287961_+\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	99.1
WP_000836471.1\|2287982_2288294_+	rhodanese-like domain-containing protein	A0A2H4PQR9	Staphylococcus_phage	1.3e-49	95.1
WP_001050515.1\|2288617_2295166_+	LPXTG-anchored repetitive surface protein SasC	A0A2H4PQU6	Staphylococcus_phage	5.7e-296	95.1

DBSCAN-SWA_9

2497367 : 2505679

Caulobacter_phage(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001217255.1\|2497367_2499167_+	DNA primase	A0A0K1LMQ9	Caulobacter_phage	3.5e-54	36.0
WP_001283055.1\|2499390_2500497_+	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	1.1e-37	38.1
WP_000624563.1\|2500627_2501305_+\|tRNA	tRNA (adenine-N(1))-methyltransferase	NA	NA	NA	NA
WP_000683941.1\|2501307_2502408_+	Nif3-like dinuclear metal center hexameric protein	A0A1S5V250	Saudi_moumouvirus	1.0e-08	30.6
WP_001062170.1\|2502521_2503868_+	DEAD/DEAH box helicase	A0A1V0SIR5	Klosneuvirus	3.4e-54	33.7
WP_000924214.1\|2503877_2504768_+	deoxyribonuclease IV	A0A2H4UU70	Bodo_saltans_virus	2.0e-26	33.1
WP_001213908.1\|2504893_2505679_+	metal ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.0e-19	28.3

DBSCAN-SWA_10

2560801 : 2650332

111

Staphylococcus_phage(74.7%)

capsid,plate,integrase,head,terminase,holin,portal,protease,tRNA,tail

attL 2563552:2563569|attR 2615379:2615396

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000064078.1\|2560801_2561527_+	two-component system response regulator SrrA	W8CYM9	Bacillus_phage	3.5e-45	43.0
WP_000987760.1\|2561507_2563259_+	two-component system sensor histidine kinase SrrB	A0A1V0SGX0	Hokovirus	1.3e-21	33.3
WP_001825329.1\|2563503_2564433_+	DUF1672 domain-containing protein	NA	NA	NA	NA
2563552:2563569	attL	NA	NA	NA	NA
WP_014532489.1\|2564425_2566453_+	hypothetical protein	B5WZK7	Staphylococcus_phage	2.7e-111	95.3
WP_031585161.1\|2566495_2567701_-\|integrase	site-specific integrase	A0A2I6PEN0	Staphylococcus_phage	3.8e-222	99.8
WP_001568848.1\|2567826_2568441_+	phage protein	A7TW88	Staphylococcus_phage	1.0e-106	99.5
WP_001795334.1\|2568437_2568584_-	hypothetical protein	A0A2I6PEK8	Staphylococcus_phage	1.2e-16	100.0
WP_000825948.1\|2568813_2569398_-	hypothetical protein	A0A2I6PD77	Staphylococcus_phage	1.4e-68	100.0
WP_000525004.1\|2569415_2569877_-	hypothetical protein	A0A2K9VBR7	Staphylococcus_phage	1.2e-83	100.0
WP_000333630.1\|2569889_2570204_-	helix-turn-helix transcriptional regulator	A0A0N9BAW4	Staphylococcus_phage	9.8e-53	100.0
WP_001121027.1\|2570355_2570592_+	helix-turn-helix transcriptional regulator	A0A2I6PD81	Staphylococcus_phage	1.5e-37	100.0
WP_001148544.1\|2570605_2571382_+	Rha family transcriptional regulator	A0A2I6PD87	Staphylococcus_phage	1.1e-140	100.0
WP_000771849.1\|2571410_2571560_+	hypothetical protein	D2JGJ0	Staphylococcus_phage	1.4e-20	100.0
WP_000362644.1\|2571600_2571813_-	hypothetical protein	D2JGJ1	Staphylococcus_phage	7.6e-33	100.0
WP_001148860.1\|2571882_2572080_+	hypothetical protein	A7TWF5	Staphylococcus_phage	4.6e-24	100.0
WP_000773059.1\|2572066_2572447_-	DUF2513 domain-containing protein	Q4ZCQ5	Staphylococcus_virus	5.8e-68	100.0
WP_001025401.1\|2572501_2572747_+	DUF2829 domain-containing protein	A0A2I6PF15	Staphylococcus_phage	5.1e-41	100.0
WP_001128433.1\|2572715_2573081_-	hypothetical protein	A0A2I6PF07	Staphylococcus_phage	2.4e-63	100.0
WP_001097552.1\|2573135_2573351_+	hypothetical protein	A0A2I6PF01	Staphylococcus_phage	1.9e-31	100.0
WP_016187436.1\|2573375_2573639_+	helix-turn-helix domain-containing protein	M9QRR6	Staphylococcus_phage	9.7e-46	100.0
WP_001285948.1\|2573651_2573813_+	DUF1270 domain-containing protein	A9CR58	Staphylococcus_phage	1.1e-20	98.1
WP_000174994.1\|2573891_2574215_+	hypothetical protein	A0A2I6PF12	Staphylococcus_phage	5.9e-53	100.0
WP_031863778.1\|2574229_2574592_+	hypothetical protein	A0A2I6PF03	Staphylococcus_phage	7.1e-55	98.3
WP_031775793.1\|2574588_2575755_+	DUF2800 domain-containing protein	Q8SDR9	Staphylococcus_virus	2.2e-219	99.2
WP_000647288.1\|2575781_2576336_+	DUF2815 family protein	M9QRS1	Staphylococcus_phage	1.4e-99	100.0
WP_114668462.1\|2576404_2578357_+	DNA polymerase	M9QT72	Staphylococcus_phage	0.0e+00	98.8
WP_079219803.1\|2578368_2578530_+	hypothetical protein	A7TWH0	Staphylococcus_phage	1.7e-21	100.0
WP_114668454.1\|2578538_2578787_+	hypothetical protein	A7TWH1	Staphylococcus_phage	2.4e-38	93.9
WP_000693989.1\|2578800_2579007_+	hypothetical protein	A0A2K9VBT9	Staphylococcus_phage	3.0e-34	100.0
WP_000695771.1\|2579009_2579417_+	hypothetical protein	M9NST1	Staphylococcus_phage	2.6e-74	98.5
WP_000983950.1\|2579413_2579608_+	hypothetical protein	A0A0U2A067	Staphylococcus_phage	1.4e-25	96.8
WP_000982714.1\|2579604_2580042_+	hypothetical protein	NA	NA	NA	NA
WP_031910183.1\|2580038_2580323_+	hypothetical protein	Q9MBR2	Staphylococcus_prophage	2.2e-43	93.6
WP_000370297.1\|2580315_2580567_+	DUF1024 family protein	A7TWH5	Staphylococcus_phage	1.2e-34	90.5
WP_000714407.1\|2580553_2580724_+	hypothetical protein	A0A1W6JQ22	Staphylococcus_phage	5.7e-23	100.0
WP_001066452.1\|2580716_2581253_+	dUTP diphosphatase	A0A1W6JPM9	Staphylococcus_phage	1.2e-95	100.0
WP_000195801.1\|2581289_2581577_+	DUF1381 domain-containing protein	Q4ZAB6	Staphylococcus_virus	1.1e-45	100.0
WP_000608279.1\|2581569_2581806_+	hypothetical protein	A0A0N7E0U3	Staphylococcus_phage	1.3e-36	100.0
WP_001568228.1\|2581795_2582185_+	hypothetical protein	M9QX07	Staphylococcus_phage	2.8e-65	100.0
WP_000595260.1\|2582181_2582334_+	transcriptional activator RinB	A7TWI2	Staphylococcus_phage	2.6e-19	100.0
WP_031794940.1\|2582401_2582602_+	DUF1514 family protein	A0A2I6PF41	Staphylococcus_phage	3.8e-26	98.5
WP_000884844.1\|2582653_2585101_+	virulence-associated E family protein	R4WAL1	Staphylococcus_phage	0.0e+00	100.0
WP_001801650.1\|2585209_2585308_-	hypothetical protein	A0A2I6PDP6	Staphylococcus_phage	3.7e-11	100.0
WP_000665203.1\|2585441_2585732_+	VRR-NUC domain-containing protein	A0A2I6PEN7	Staphylococcus_phage	6.5e-51	100.0
WP_078100893.1\|2585712_2587080_+	DEAD/DEAH box helicase	A0A2I6PE95	Staphylococcus_phage	1.1e-260	98.9
WP_000513702.1\|2587092_2587530_+	transcriptional regulator	B7T0I6	Staphylococcus_virus	6.1e-77	100.0
WP_015994756.1\|2587686_2588001_+	HNH endonuclease	A0A0K1LL59	Staphylococcus_phage	4.2e-56	100.0
WP_000778933.1\|2588126_2588432_+\|terminase	P27 family phage terminase small subunit	A0A2I6PEQ6	Staphylococcus_phage	2.9e-49	100.0
WP_000153552.1\|2588421_2590113_+\|terminase	terminase large subunit	A0A2I6PE99	Staphylococcus_phage	0.0e+00	98.8
WP_001100664.1\|2590117_2591356_+\|portal	phage portal protein	A0A2I6PER5	Staphylococcus_phage	6.9e-235	100.0
WP_021285854.1\|2591339_2592113_+\|protease	Clp protease ClpP	A0A2I6PEQ7	Staphylococcus_phage	9.2e-137	99.6
WP_031794937.1\|2592124_2593288_+\|capsid	phage major capsid protein	M9QQM0	Staphylococcus_phage	2.1e-217	99.7
WP_000050973.1\|2593356_2593635_+\|head,tail	phage gp6-like head-tail connector protein	A0A2I6PEQ1	Staphylococcus_phage	2.1e-46	100.0
WP_016187452.1\|2593646_2593979_+	hypothetical protein	M9QX19	Staphylococcus_phage	1.1e-57	100.0
WP_031794936.1\|2593975_2594377_+	phage protein	A0A0K1LL98	Staphylococcus_phage	4.0e-67	99.2
WP_001023808.1\|2594377_2594773_+	DUF3168 domain-containing protein	A0A0K1LKC0	Staphylococcus_phage	5.1e-67	100.0
WP_000807536.1\|2594807_2595449_+\|tail	tail protein	A0A2I6PEP6	Staphylococcus_phage	5.9e-121	100.0
WP_000169128.1\|2595540_2595996_+	Ig domain-containing protein	A0A2I6PF45	Staphylococcus_phage	1.3e-77	100.0
WP_031775785.1\|2596053_2596404_+	hypothetical protein	A0A2I6PEQ2	Staphylococcus_phage	2.0e-54	99.1
WP_000438833.1\|2596445_2596604_+	hypothetical protein	A0A2I6PES8	Staphylococcus_phage	1.2e-19	100.0
WP_079219800.1\|2596617_2602818_+\|tail	phage tail tape measure protein	A0A1X9IGU9	Staphylococcus_phage	0.0e+00	97.8
WP_031775783.1\|2602817_2603642_+\|tail	phage tail family protein	A0A2I6PER3	Staphylococcus_phage	7.0e-159	99.6
WP_000384460.1\|2603650_2605234_+\|tail	phage tail protein	Q4ZD01	Staphylococcus_virus	3.5e-308	99.8
WP_000179864.1\|2605233_2605524_+	hypothetical protein	R4WEC3	Staphylococcus_phage	2.1e-49	100.0
WP_000429556.1\|2605539_2607450_+	hypothetical protein	A0A2I6PF35	Staphylococcus_phage	0.0e+00	99.2
WP_031776075.1\|2607449_2608916_+\|plate	phage baseplate upper protein	A0A2I6PES7	Staphylococcus_phage	4.4e-273	99.8
WP_001166606.1\|2608915_2609305_+	DUF2977 domain-containing protein	Q4ZCZ7	Staphylococcus_virus	5.4e-61	95.3
WP_000916022.1\|2609297_2609462_+	XkdX family protein	M9QX31	Staphylococcus_phage	1.9e-23	98.1
WP_000466774.1\|2609507_2609807_+	DUF2951 family protein	M9QRV2	Staphylococcus_phage	2.6e-31	100.0
WP_000354117.1\|2609942_2610380_+\|holin	phage holin	M9QTA6	Staphylococcus_phage	3.8e-71	97.9
WP_001148129.1\|2610360_2611806_+	SH3 domain-containing protein	Q4ZB16	Staphylococcus_virus	1.7e-288	96.9
WP_000201920.1\|2612708_2612888_+	hypothetical protein	M9QYR8	Staphylococcus_phage	4.1e-24	100.0
WP_000455173.1\|2612909_2613437_+	DUF4065 domain-containing protein	M9QX37	Staphylococcus_phage	3.4e-98	100.0
WP_016187462.1\|2613408_2613825_+	hypothetical protein	M9QRV7	Staphylococcus_phage	6.4e-76	100.0
WP_000126130.1\|2614040_2614256_+	hypothetical protein	A0ZS61	Staphylococcus_virus	2.0e-25	100.0
WP_001825313.1\|2614346_2615276_+	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_001807840.1\|2615330_2616227_+	DUF1672 domain-containing protein	NA	NA	NA	NA
2615379:2615396	attR	NA	NA	NA	NA
WP_001825312.1\|2616681_2617614_+	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_001186909.1\|2618017_2618563_+	ECF transporter S component	NA	NA	NA	NA
WP_001151997.1\|2618668_2618917_-	ferredoxin	A0A127AYY7	Bacillus_phage	8.3e-15	48.0
WP_001163801.1\|2619024_2619978_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_114668456.1\|2619967_2621347_+	ATP-dependent DNA helicase RecQ	L7RCS0	Acanthamoeba_polyphaga_moumouvirus	2.4e-55	33.8
WP_000069278.1\|2621499_2622954_+	elastin-binding protein EbpS	NA	NA	NA	NA
WP_001807838.1\|2623079_2623196_+	hypothetical protein	NA	NA	NA	NA
WP_001174257.1\|2623356_2624343_+	YpdA family putative bacillithiol disulfide reductase	NA	NA	NA	NA
WP_000681742.1\|2624457_2625426_-	asparaginase	NA	NA	NA	NA
WP_000644390.1\|2625502_2626162_+	(d)CMP kinase	NA	NA	NA	NA
WP_001807839.1\|2626192_2626309_+	hypothetical protein	NA	NA	NA	NA
WP_001825307.1\|2626425_2626617_+	hypothetical protein	NA	NA	NA	NA
WP_000133960.1\|2626873_2628049_+	30S ribosomal protein S1	NA	NA	NA	NA
WP_000165530.1\|2628270_2629581_+	ribosome biogenesis GTPase Der	NA	NA	NA	NA
WP_000161737.1\|2629597_2630596_+	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_001043863.1\|2630766_2631039_+	HU family DNA-binding protein	A7KV42	Bacillus_phage	4.2e-28	73.3
WP_000450555.1\|2631469_2632042_+	heptaprenyl diphosphate synthase component 1	NA	NA	NA	NA
WP_000774681.1\|2632044_2632770_+	demethylmenaquinone methyltransferase	NA	NA	NA	NA
WP_001096479.1\|2632771_2633731_+	polyprenyl synthetase family protein	A0A1V0SE37	Indivirus	1.3e-10	24.4
WP_000442480.1\|2633822_2634272_+	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	2.4e-28	43.8
WP_000789522.1\|2634477_2634678_+	hypothetical protein	NA	NA	NA	NA
WP_001269939.1\|2635064_2636231_+	chorismate synthase	A0A291AU41	Pandoravirus	2.6e-34	32.3
WP_000776339.1\|2636256_2637321_+	3-dehydroquinate synthase	NA	NA	NA	NA
WP_000245908.1\|2637330_2638629_+	3-phosphoshikimate 1-carboxyvinyltransferase	NA	NA	NA	NA
WP_000389530.1\|2638635_2639880_+	hypothetical protein	NA	NA	NA	NA
WP_000005220.1\|2639893_2640469_+	YpiB family protein	G3MAV7	Bacillus_virus	1.6e-08	27.2
WP_000154694.1\|2640458_2641046_+	DUF1405 domain-containing protein	NA	NA	NA	NA
WP_031774809.1\|2641117_2641798_+	zinc metallopeptidase	NA	NA	NA	NA
WP_000839926.1\|2642132_2642450_+	nucleotide pyrophosphohydrolase	NA	NA	NA	NA
WP_000690021.1\|2642693_2643836_+	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA	NA	NA	NA	NA
WP_000361538.1\|2643840_2645043_+\|tRNA	CCA tRNA nucleotidyltransferase	H7BUW3	unidentified_phage	7.1e-35	43.3
WP_000049916.1\|2645029_2646001_+	biotin--[acetyl-CoA-carboxylase] ligase	NA	NA	NA	NA
WP_000525056.1\|2646024_2648718_+	ATP-dependent helicase	A0A1X9I5C8	Streptococcus_phage	1.4e-46	34.3
WP_000858789.1\|2649039_2650332_+\|tRNA	asparagine--tRNA ligase	A0A2P1EMB4	Moumouvirus	1.9e-54	30.0

DBSCAN-SWA_11

2827092 : 2832280

Staphylococcus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001215406.1\|2827092_2827266_+	hypothetical protein	A0A059NT83	Lactococcus_phage	3.6e-09	51.9
WP_000974166.1\|2827329_2827914_+	ATP-binding protein	A0A059NT77	Lactococcus_phage	4.4e-30	42.6
WP_000477490.1\|2828345_2828762_-	hypothetical protein	NA	NA	NA	NA
WP_000006110.1\|2829272_2829458_-	hypothetical protein	A0A0F6N3H3	Staphylococcus_phage	2.4e-19	78.7
WP_001788716.1\|2829850_2829961_-	hypothetical protein	NA	NA	NA	NA
WP_001002341.1\|2830661_2830868_-	hypothetical protein	A0A2H4PQT0	Staphylococcus_phage	5.5e-12	55.2
WP_074347689.1\|2831168_2831396_-	hypothetical protein	A0A1W6JNK0	Staphylococcus_phage	1.9e-18	72.1
WP_001807853.1\|2832082_2832280_-	hypothetical protein	A0A1W6JNK0	Staphylococcus_phage	9.9e-11	50.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_LT992456

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection