CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_LS483304	Staphylococcus hyicus strain NCTC10350 chromosome 1	2 crisprs	cas9,cas1,WYL,DEDDh,cas3,DinG,csa3	0	11	9	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_LS483304_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LS483304_1

225769-226727

TypeII

Consensus_repeat	Method
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	PILER-CR
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	CRISPRCasFinder
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	CRT

14 spacers

cas9,cas1

The CRISPR arrays of NZ_LS483304_1

>merge|NZ_LS483304|1|225769-226727|PILER-CR,CRISPRCasFinder,CRT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAACTTAGGGTCCCAATAAATCATTTGACCTTTAGTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAACTTTAGCAACTTTTTTATAACTATCACCATTGTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAACGGTAAAACAACGTACAAGTGAATTTGATAGGTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAACCGCTAAAGAGGCACTCTCAACTACTATCCGGTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAACTGATGCCCCGGTCAAGCGTTTTTTGTTTGCTGTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAACAAGATGGTTTAATAGCAGTATGGAATGGCAGTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAACAACTTTGACGTACTTCAACAATATTTTACTGTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAACTTGATAACTTCGGTTTAGGTGATTTTATCAGTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAACATTTTCTATGCATTACCTTTATGAAGGGGTGTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAACTTCATGTCGCCTGTGGGCTTTGTTAAGTTAGTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAACTTTGGTAGCCATTTACTTCACAAGAGAGGGTTTTAGTACTCTGAAATTTTAGGTATAAGTGAAACGAATATGTAGGTTCTAATATACTGTCACCTGTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAACAGAAATACTTGTAAACACAGCAAGCCTTGTGTTTTAGTACTCTGTAATTATAGTTATAGGTGAAAAAAAGAATAGAATTGGCGTTGTGCGCAGATAGCTTAGTACTTTGTGATTTTAGGTATTTTTATAAG

>NZ_LS483304|1|1|225769-226596|PILER-CR
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	TTAGGGTCCCAATAAATCATTTGACCTTTA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	TTTAGCAACTTTTTTATAACTATCACCATT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	GGTAAAACAACGTACAAGTGAATTTGATAG
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	CGCTAAAGAGGCACTCTCAACTACTATCCG
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	TGATGCCCCGGTCAAGCGTTTTTTGTTTGCT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	AAGATGGTTTAATAGCAGTATGGAATGGCA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	AACTTTGACGTACTTCAACAATATTTTACT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	TTGATAACTTCGGTTTAGGTGATTTTATCA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	ATTTTCTATGCATTACCTTTATGAAGGGGT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	TTCATGTCGCCTGTGGGCTTTGTTAAGTTA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	TTTGGTAGCCATTTACTTCACAAGAGAGG
GTTTTAGTACTCTGAAATTTTAGGTATAAGTGAAAC	GAATATGTAGGTTCTAATATACTGTCACCT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC

>NZ_LS483304|1|1|225769-226727|CRISPRCasFinder
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	TTAGGGTCCCAATAAATCATTTGACCTTTA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	TTTAGCAACTTTTTTATAACTATCACCATT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	GGTAAAACAACGTACAAGTGAATTTGATAG
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	CGCTAAAGAGGCACTCTCAACTACTATCCG
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	TGATGCCCCGGTCAAGCGTTTTTTGTTTGCT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	AAGATGGTTTAATAGCAGTATGGAATGGCA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	AACTTTGACGTACTTCAACAATATTTTACT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	TTGATAACTTCGGTTTAGGTGATTTTATCA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	ATTTTCTATGCATTACCTTTATGAAGGGGT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	TTCATGTCGCCTGTGGGCTTTGTTAAGTTA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	TTTGGTAGCCATTTACTTCACAAGAGAGG
GTTTTAGTACTCTGAAATTTTAGGTATAAGTGAAAC	GAATATGTAGGTTCTAATATACTGTCACCT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	AGAAATACTTGTAAACACAGCAAGCCTTGT
GTTTTAGTACTCTGTAATTATAGTTATAGGTGAAAA	AAAGAATAGAATTGGCGTTGTGCGCAGAT
AGCTTAGTACTTTGTGATTTTAGGTATTTTTATAAG

>NZ_LS483304|1|1|225769-226662|CRT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	TTAGGGTCCCAATAAATCATTTGACCTTTA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	TTTAGCAACTTTTTTATAACTATCACCATT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	GGTAAAACAACGTACAAGTGAATTTGATAG
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	CGCTAAAGAGGCACTCTCAACTACTATCCG
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	TGATGCCCCGGTCAAGCGTTTTTTGTTTGCT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	AAGATGGTTTAATAGCAGTATGGAATGGCA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	AACTTTGACGTACTTCAACAATATTTTACT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	TTGATAACTTCGGTTTAGGTGATTTTATCA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	ATTTTCTATGCATTACCTTTATGAAGGGGT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	TTCATGTCGCCTGTGGGCTTTGTTAAGTTA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	TTTGGTAGCCATTTACTTCACAAGAGAGG
GTTTTAGTACTCTGAAATTTTAGGTATAAGTGAAAC	GAATATGTAGGTTCTAATATACTGTCACCT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGAAAC	AGAAATACTTGTAAACACAGCAAGCCTTGT
GTTTTAGTACTCTGTAATTATAGTTATAGGTGAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LS483304.1\|WP_039643664.1\|214930_215842_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|340424
NZ_LS483304.1\|WP_039643683.1\|231431_232433_+\|hypothetical-protein	unknown	unknown	unknown
NZ_LS483304.1\|WP_039643675.1\|223074_224736_-\|FAD-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|183782
NZ_LS483304.1\|WP_039643687.1\|234049_235774_-\|glycoside-hydrolase-family-3-protein	unknown	unknown	gnl\|CDD\|224389
NZ_LS483304.1\|WP_039643695.1\|238924_239938_+\|sugar-kinase	unknown	unknown	gnl\|CDD\|238571
NZ_LS483304.1\|WP_039643672.1\|221062_222652_+\|acyl--CoA-ligase	unknown	unknown	gnl\|CDD\|341276
NZ_LS483304.1\|WP_039643667.1\|216683_218645_+\|FtsX-like-permease-family-protein	unknown	unknown	unknown
NZ_LS483304.1\|WP_039643679.1\|227036_230192_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|273840
NZ_LS483304.1\|WP_039643689.1\|235776_236622_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223620
NZ_LS483304.1\|WP_158484607.1\|224917_225055_+\|hypothetical-protein	unknown	unknown	unknown
NZ_LS483304.1\|WP_039643677.1\|225122_225545_-\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|107228
NZ_LS483304.1\|WP_039643669.1\|218881_219508_-\|FMN-dependent-NADH-azoreductase	unknown	unknown	gnl\|CDD\|234675
NZ_LS483304.1\|WP_039643685.1\|232517_233855_-\|Nramp-family-divalent-metal-transporter	unknown	unknown	gnl\|CDD\|234815
NZ_LS483304.1\|WP_039643691.1\|236675_237914_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_LS483304.1\|WP_039643670.1\|219739_220060_-\|SPIN-family-peroxidase-inhibitor	unknown	unknown	unknown
NZ_LS483304.1\|WP_039643697.1\|239953_241357_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|225121
NZ_LS483304.1\|WP_039643681.1\|230203_231106_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|274694
NZ_LS483304.1\|WP_039643662.1\|214256_214922_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_LS483304.1\|WP_039643693.1\|238278_238920_+\|bifunctional-2-keto-4-hydroxyglutarate-aldolase/2-keto-3-deoxy-6-phosphogluconate-aldolase	unknown	unknown	gnl\|CDD\|180618
NZ_LS483304.1\|WP_039643665.1\|215932_216682_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224059

Protein	Function_ID	Function_description	E-value
NZ_LS483304.1\|WP_039643664.1\|214930_215842_+\|sensor-histidine-kinase	gnl\|CDD\|340424	cd16948, HATPase_BceS-YxdK-YvcQ-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ. This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.	8.23591e-40
NZ_LS483304.1\|WP_039643695.1\|238924_239938_+\|sugar-kinase	gnl\|CDD\|238571	cd01166, KdgK, 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources.	2.28288e-77
NZ_LS483304.1\|WP_039643675.1\|223074_224736_-\|FAD-binding-dehydrogenase	gnl\|CDD\|183782	PRK12834, PRK12834, putative FAD-binding dehydrogenase; Reviewed.	0
NZ_LS483304.1\|WP_039643687.1\|234049_235774_-\|glycoside-hydrolase-family-3-protein	gnl\|CDD\|224389	COG1472, BglX, Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism].	2.30443e-58
NZ_LS483304.1\|WP_039643672.1\|221062_222652_+\|acyl--CoA-ligase	gnl\|CDD\|341276	cd05972, MACS_like, Medium-chain acyl-CoA synthetase (MACS or ACSM). MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes.	0
NZ_LS483304.1\|WP_039643679.1\|227036_230192_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|273840	TIGR01865, conserved_hypothetical_protein, CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1. CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein found only in CRISPR-containing species, near other CRISPR-associated proteins (cas), as part of the NMENI subtype of CRISPR/Cas locus. The species range so far for this protein is animal pathogens and commensals only.	3.78792e-119
NZ_LS483304.1\|WP_039643689.1\|235776_236622_-\|HAD-family-hydrolase	gnl\|CDD\|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	5.44578e-07
NZ_LS483304.1\|WP_039643677.1\|225122_225545_-\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|107228	cd06471, ACD_LpsHSP_like, Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits. Transcription of the genes encoding Lp HSP 18.5, 18.55 and 19.3 is regulated by a variety of stresses including heat, cold and ethanol. Early growing L. plantarum cells contain elevated levels of these mRNAs which rapidly fall of as the cells enter stationary phase. Also belonging to this group is Bifidobacterium breve (Bb) HSP20 and Oenococcus oenis (syn. Leuconostoc oenos) (Oo) HSP18. Transcription of the gene encoding BbHSP20 is strongly induced following heat or osmotic shock, and that of the gene encoding OoHSP18 following heat, ethanol or acid shock. OoHSP18 is peripherally associated with the cytoplasmic membrane.	1.23317e-41
NZ_LS483304.1\|WP_039643669.1\|218881_219508_-\|FMN-dependent-NADH-azoreductase	gnl\|CDD\|234675	PRK00170, PRK00170, azoreductase; Reviewed.	1.52821e-102
NZ_LS483304.1\|WP_039643685.1\|232517_233855_-\|Nramp-family-divalent-metal-transporter	gnl\|CDD\|234815	PRK00701, PRK00701, divalent metal cation transporter MntH.	0
NZ_LS483304.1\|WP_039643691.1\|236675_237914_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.45256e-28
NZ_LS483304.1\|WP_039643697.1\|239953_241357_+\|MFS-transporter	gnl\|CDD\|225121	COG2211, MelB, Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism].	5.70622e-133
NZ_LS483304.1\|WP_039643681.1\|230203_231106_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274694	TIGR03639, cas1_NMENI, CRISPR-associated endonuclease Cas1, subtype II/NMENI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.	2.04456e-96
NZ_LS483304.1\|WP_039643662.1\|214256_214922_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.80703e-60
NZ_LS483304.1\|WP_039643693.1\|238278_238920_+\|bifunctional-2-keto-4-hydroxyglutarate-aldolase/2-keto-3-deoxy-6-phosphogluconate-aldolase	gnl\|CDD\|180618	PRK06552, PRK06552, keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; Provisional.	4.04497e-98
NZ_LS483304.1\|WP_039643665.1\|215932_216682_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	1.25525e-103

>NZ_LS483304.1|WP_039643677.1|225122_225545_-|Hsp20/alpha-crystallin-family-protein
MAFQLKPFNHSIFDMNSSDLFKDFGQGLMLSQAFKTDISEREDAYVVSAELPGMAKSDIHVDFDNNILTIAAAHTENNEKENEDGVIVHRERRTSSVKRQFTFNNVERDTIHASYDNGVLEITLPKLQHSETSPSRIPIN
>NZ_LS483304.1|WP_158484607.1|224917_225055_+|hypothetical-protein
MKKGKQVQWMHKVIVGTALFVLGSSLVVGAFENVHIVPEKVHQVR
>NZ_LS483304.1|WP_039643675.1|223074_224736_-|FAD-binding-dehydrogenase
MQKHIHIIGAGLSGLVAATELLKRGHRVTLIDQEPPQAMGGQAYWSFGGLFLVNSKVQRCLGVKDSYDLALSDWLGSAGFDRLQEDDYWAYQWAKAYVHFATYEKEAYLKHMGITLTPILGWAERGGHSASGHGNSVPRFHITWGTGPGLVNPFIGFVKKYEASGQFTFLPRHQVTDIEIVGDAIKSISGNILEQSDVPIGAPSSRKAVDTFQFEVSYLLITTGGIGANEALIRQNWPQRLGAAPKTMIQGVPDSTDGKMLEISEDAGVNLVNKDRMWHYTEGIQNHSPIWNKHGIRIIPGPSSMWFTATGKRMRAPDYPGFDTLHTLETIMKTGYDYSWFILTEDIVKKEFVLSGSEQNPDLTNKDIRRLIKERLGKKATGPVQAFLNKGADFVMANDLKTLVEKMNALTGENLIDYNHVKHEIEARDLQLMNTFSKDPQVTFIHNARHFLGDKLIRTAKPHPILSGKNGKLIAVKLHIISRKTLGGIQTDLDGQAFNQHRERIKGLYAAGEASGFGGGGVHGYRALEGTFLGGCIFSGIRAAEGIHKSIPT
>NZ_LS483304.1|WP_039643672.1|221062_222652_+|acyl--CoA-ligase
MNLSGLVAPEHYNIVDEIEKYAQTSDKLALIYESGFHPPQKVTYETLIHHANQVAHVMQFHGLQKGDRVLIMLPRMVETYEVYIAALKLGLTVIPSSEMLRTKDLQYRIRHANVKAVITLPDYIKEFENVTEYEALIKLLVTGDHADWTTIATEKSQFPTQCDKQETHRDDLAILSYTSGTTGNPKAVMHTHGWGYAHMRLAPKQWLNIEEDDLVWATAAPGWQKWIWSPFLSIMGSGATAFVYNGKFKASRYLELLQDFKINVLCCTPTEYRMMAKLQNLTEYDLSHLKSAVSAGEPLNKDVVNKFETHFNLTVRDGYGQTESTLLIGFLEDTPKRPGAMGKAIPGTGVTIVDDEGNELGSNEEGNIAVPLSLPALFKGYFNDHERTEEARLAGYHITGDLAQKDEDGYFWFEGRKDDIIISSGYTIGPFEVEDALTHHEAVKECAVVASPHAERGNIVKAFVILQEGYERSDTLILNMQQFVKESVAPYKYPRAIEFVDTLPKTNSGKIRRIELRQAEQRKFARDEI
>NZ_LS483304.1|WP_039643670.1|219739_220060_-|SPIN-family-peroxidase-inhibitor
MSLNKIILSAVTTGVLATGIFAAVPHQQAEASVLSKGGIILQDDSRILEHEVDYVGVLLDKKTDKKTKAGIRAYFKLLGYKSAKDFLKAAKAQGLDTSKYDYLLKK
>NZ_LS483304.1|WP_039643669.1|218881_219508_-|FMN-dependent-NADH-azoreductase
MAKLLFITAHPLDELVSNSMAAGQAFIKSYEAHHPDDEIVHVDLFKEYVPYIDGDVFSAWGKVQNGDVLTAEEETKVTRLNEILEQFVNADKYVFVTPMWNLSFPPVVKAYIDAVAVAGQTFKYTSNGPVGLLTNKKALHIQSRGGYYTEAPANALEHGDSYIKAMMGFFGVPSYDTVIIEGHNKDPERSEEIKAAAILKAQSLGETF
>NZ_LS483304.1|WP_039643667.1|216683_218645_+|FtsX-like-permease-family-protein
MTLKLLLKLVKRNFVALKSLFIPFILTASIMIGLEYILLSIITNDYIVRRHGLLPGLLMYVNVIIMILSVIFIIYANSFIMKRRRKEYALQMVLGLEKKHLHIISFIELCMQFIVVSVLSIVGGYLFGNLLFLFLNKLVSQTPISIMHYPFSVKAMVITLVMGTVLFIVLFFINIIHTSTRSPIKLMNESHAGEKRTRKWILIPLCIIGALCLGYGYYLALSTQTVASSFKTIFAAIFFVMVGTYALFMSLSLLFLQGLQRVPKIYYRPRNFFSISGLLSRMKVNVVGLASITMLCTFLIVTMGMTLTTYRGLENQVENSITEDYKITVFENYNFSKKASERVEALKKDIDQIATVDRYRIYGSEFISFQIKNHALVPPKKGTDLYMNDLLYGVVVTQKDHNKARHAHINLKDNEVVFDSDASVFKGIKDVKIAGKSYNVIQSNNHEIGNQIVGDSVYIIVKDNDAFKKIIKQYMNEGSLGNTAIDFNVQNNKEALNKALPQLQKKHQVTINSKDEIRKSLYELNGGLIFMGIVVSIVLLSGTFLMLYNKQISEGYEDKRNFDIMQKVGLDYRLIKQTIQRQIMWVFVLPIMVAVIHTLFAGKIIYKLLGILGISDVSLFLTSYMSVTFIVVLIYGFMYWITSTIYYKIVQMK
>NZ_LS483304.1|WP_039643665.1|215932_216682_+|ABC-transporter-ATP-binding-protein
MLLNVRHLKKVYGKGINKVTALNEMSFNVQEGEFVAIMGESGSGKSTLLNLIATFDRPTEGAITINQQDIGQLRNKAISRFRRDELGFVFQDFNVLDTMSNKDNILMPLVLSNINVKTMQKRLTKVTQQLGIERLLDKYPYQVSGGQRQRVAIARALINEPQLLLADEPTGALDSKTSQEIMTMFKDINERNQTILMVTHSIQDASFANRILFIKDGGLYHELYRGDESQQAFQKRISDSLALLNGRGV
>NZ_LS483304.1|WP_039643664.1|214930_215842_+|sensor-histidine-kinase
MSVRFYNHILSDVCIYVLMLMLFLFISLIYDFETEAYILTLSVSLFVFSLYIIVKWTYFKKQETLKQTNERLASELQHVKMMHRAYQRDLEHYFLTWVHQIKTPITASKLLLERNEAGMVNRVRQEITEIENYTNLALNYLKLLSHETDMVVQKVALDDIVKPLIQRYALHFIEHRTRIHTEHLHCTVTTDAQWTKIMIEQILNNALKYAKGGDIWIEFDAHKQQLTIKDNGMGISKADLPKIFEKGYSGTNGRLNDKSSGIGLFIVKEISEKLQHPITVQSELGVLTQFTIQFPKTSHLTIM
>NZ_LS483304.1|WP_039643662.1|214256_214922_+|response-regulator-transcription-factor
MKIMIVEDDFTIAESLVKELQKWNHEAVNVQDYYHIAEKFQTLQPHLVLLDINLPHLNGFHWCQEIRQKSQVPIIFISSASDNMNQMMAIQMGADDFIEKPFNLKLTIMKIQALLRRSYDFKVEQSQLHVKGCALIVDKALLIYQDQTLSLTLTELQILQQLFINEGHFVNRNTLIEHCWQSENFIDDNTLAVNMSRIRKKLKELGLVDFIQTKKNVGYKV
>NZ_LS483304.1|WP_039643679.1|227036_230192_+|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MNNYILGLDIGITSVGYGIVDSDTREIKDAGVRLFPEANVDNNEGRRSKRGARRLKRRRIHRLDRVKHLLAEYDLLDLTNIPKSTNPYQTRVKGLNEKLSKDELVIALLHIAKRRGIHNVNVMMDDNDSGNELSTKDQLKKNAKALSDKYVCELQLERFEQDYKVRGEKNRFKTEDFVREARKLLETQSKFFEIDQTFIMRYIELIETRREYFEGPGKGSPFGWEGNIKKWFEQMMGHCTYFPEELRSVKYSYSAELFNALNDLNNLVITRDEDAKLNYGEKFQIIENVFKQKKTPNLKQIAIEIGVHETEIKGYRVNKSGKPEFTQFKLYHDLKNIFKDPKYLNDIQLMDNIAEIITIYQDAESIIKELNQLPELLSEREKEKISALSGYSGTHRLSLKCINLLLDDLWESSLNQMELFTKLNLKPKKIDLSQQHKIPSKLVDDFILSPVVKRAFIQSIQVVNAIIDKYGLPEDIIIELARENNSDDRRKFLNQLQKQNEETRKQVEKVLREYGNDNAKRIVQKIKLHNMQEGKCLYSLKDIPLEDLLRNPHHYEVDHIIPRSVAFDNSMHNKVLVRADENSKKGNRTPYQYLNSSESSLSYNEFKQHILNLSKTKDRITKKKREYLLEERDINKFDVQKEFINRNLVDTRYATRELTSLLKAYFSANNLDVKVKTINGSFTNYLRKVWKFDKDRNKGYKHHAEDALIIANADFLFKHNKKLRNINKVLDAPSKEVDKKRVTVQSEDEYNQIFEDTQKAQAIKKFEIRKFSHRVDKKPNRQLINDTLYSTRNIDGIEYVVESIKDIYSVNNDKVKTKFKKDPHRLLMYRNDPQTFEKFEKVFKQYESEKNPFAKYYEETGEKIRKFSKTGQGPYINKIKYLRERLGRHCDVTNKYINSRNKIVQLKIYSYRFDIYQYGNNYKMITISYIDLEQKSNYYYISREKYEQKKKDKQIDDSYKFIGSFYKNDIINYNGEMYRVIGVNDSEKNKIQLDMIDISIKDYMELNNIKKTGVIYKTIGKSTTHIEKYTTDILGNLYKAAPPKKPQLIFK
>NZ_LS483304.1|WP_039643681.1|230203_231106_+|type-II-CRISPR-associated-endonuclease-Cas1
MSWRIVYASDVSKMSLNLNSLKVTKGDLEVKIPLSDIFAVVIEDLTVTLTARLLVELSDYNILVILCNQKHLPECMLQPISGHYSQYGQMKEQLSWGQSEKDALWKMIVQQKIKNQVACMEHNGIDKERTEKMLQLKSSVKLFDRENIEGQAAKYYFNSFFTNFTRDNDDLLENAVLNYGYTILNSAIARTIVAKGLMPAMGIHHIGGRNHFNLASDLIEPFRPIVDLYLLKNPPDDFMTKQYRLNLVNLLHARVYIDGKMQTVIRAIDIMVQSIIEYFREGQPHLIKFPELCKYEFYEL
>NZ_LS483304.1|WP_039643683.1|231431_232433_+|hypothetical-protein
MNEMIWDIKCNDLDRVSLNIGHYTSIYNEHDTKEEDILQVINDYFQKRNSNKNEVIIFDDMNQETVSYASYQSWILNHELVEREHGLASNAILTKKILRNLGNHIEIGSYFNSINALHEDVLSLIKNELPICIKKFDFKAFIKLLEFHYEICEDYDRLIVRLEKILPILVEEMNAISGQKTLLIYFYPEANLSPKEQVRFRKCLENLAVPIIVLTGSMHFLSNELEHNNYLRNGEQMLTSSFINQLCWDAPLNFNETDIKQSLNKFVHLYQEKLELLPTVTNYKLGGIMLFEPIDLYVGITYLNHIGQCFELDIKYDLLNMPLQKYIKSFEKS
>NZ_LS483304.1|WP_039643685.1|232517_233855_-|Nramp-family-divalent-metal-transporter
MEVLKVNKSLEEINNTVSFKEQGSYFSRLSKFIGPGLLVAVGYMDPGNWITSMGGGASYGYILLFVILISSLSAMFLQSMSARLGIASDMDLAQVTRKMISQKYAIVAWIIAELAIIATDIAEVIGSTIALNLLFHIPLIIGATITIVDVFLLLLIMKFGFRKIEAIVGVLIFTIFIIFLFEVYMAKPDTAALLQGFIPHQDIVTNNGILYMSLGIIGATIMPHNLYLHSSIVQSRSYDRQNDASKKAAIHFAQLDSNIQLSVAFVVNCLLLILGAALFYGTSQDLGRFYELYDALKTSHVANAIGGGVTSTLFAVALLAAGQNATITGTLSGQIVMEGFIHLKMKPWVRRVITRLVAILPVFVCLLIYGADTQRIEDLLIFTQVFLSIALPLSIIPLIVATNNKGIMGAPFVNTKLVNIIGWILTIILCLLNIYLIISTLTEIV
>NZ_LS483304.1|WP_039643687.1|234049_235774_-|glycoside-hydrolase-family-3-protein
MPNVNLTEKPYFLNNQQIAWVESTIQSMSDEEKIGQLFFNLFSLEKEGDFNEGTLSNHEILEQYHIGGARYQGGNKDEVQTLLNDLQSHSKIPLLIAANCDAGGNGACNDGTYIASAAQCEATQQTQVAFNAGFISGKEAKALGVNVNFDPCVDIVENWRNTIVNTRSYGTNAETVIRYSNAYIDGYRQNNDMITCVKHFPGDGTEERDQHLVLGVNEQTVAQWDDSFRKVYENHIERGVEMIMAGHIAQPAYSKLLNPKLTDADILPASLSKELITDLLKTDLKFNGLVITDASHMLGMTASMRREDYVPLSIAAGCDMFLFFNDIEEDFNFMLNGYRNGIITEARLHDALRRILGLKAKLHLPEKQQQHTLTHAPSELDVIGATAHLEMQQEAADLGITLVKNTLNELPIKPDTHPNIRLYMIEGEKDGIYKADQSVTQNIIDILERRGFNVTLNDGSTRIKGKTLEYRQHVDAALVFANIIGYAAENNYRIRWSTAMSNEIPWYVHEVPTVFVSLNFTTHLHDATMVKTYINAYHSNKTNLEAVIDKITGVSDFKGQANDNVWTEKWEAKR
>NZ_LS483304.1|WP_039643689.1|235776_236622_-|HAD-family-hydrolase
MISALSQYTPSHTHLICIDSDGCGMDTMTIKHECAFGPAILDIWDLDAHREHILKRWNTFNLYEITRGINRFKGLEKMLTELHTQGITVEGYEDIKQWVDHTSVFSNPQLEKDILHNPEKTGLKRALAWSLRVNEKIKQLPSVGPFSHVKVSLEKVSQVADVVIVSSANQSAVENEWQHHGLMPYISGLFAQEAGTKEHCISKLKAHYQPEHMIMIGDAEGDLKAAQINNIFFYPILAHHENASWKKFYDVYSDLFISNTFYQTVQNKLIQMFYQNFEGAK
>NZ_LS483304.1|WP_039643691.1|236675_237914_+|AraC-family-transcriptional-regulator
MIDVKTLEIVKAHALDLLKLDMNVFELTDYKQMSHIFKSPFTNVKRKQFKIDFQHFISQLESRKIYHYKNLFGVQYVLFKYKKCNQIVIIGPFLEKRPNERMCHEMLLNANISISNLTTLKQYLIKVPVCHYNDALKMAHLAVRFLKNKFSHYPVMHIDFNLHPESVSYAEQKLQHHYMMTDIKDRYELENKMLAAIQNGNIDEALALHTQINLFVSGLKRLKDDLLNLKYRAYLQNTLCRKTIEKARVNLLTIDVLSAKYAALIDEAENIEILEIVTHDMIREYAETALKVNALKHTPKINKVIQYIEMYLDQTLTLSELAKSVKLSPTYLSRTFSQEIGKTIPQYIMELRLKKACDLLETTEMPIEHVAQYVGFKRQSYFSHCFKKVYGCTPIQYKQTYNEKSKRFLRWF
>NZ_LS483304.1|WP_039643693.1|238278_238920_+|bifunctional-2-keto-4-hydroxyglutarate-aldolase/2-keto-3-deoxy-6-phosphogluconate-aldolase
MKKYRILERMHHHYLVAVVRGESKEDALHTTTHIIDGGMRNIEITFTTPEAYDVIAEVKRLFSEDDIVVGAGTVLDPMTARLAIVNGAEYIVSPHLDKDIAKMCNLYSIPYLPGCGSVTEITEALTYGVDVVKLFPGDLLGANFIKNVHGPIPHIEMMPSGGVALNNLHEWIEKGAFAVGIGSALTKGAQSSHDEIIASNTEQFVKKYREIVG
>NZ_LS483304.1|WP_039643695.1|238924_239938_+|sugar-kinase
MSVITLGEILMRLSTTQHQRFQACSPLACHYGGAEMNVAIGLSGFGIPTAMITGLPKNALGNIIIQTLHRYNVNTKNVFQKEGRLGLYFVEEGFGQRAPNIIYDREHSVFNHMTLEDIHIEQMLHDYDWFHFTGITPALNDTLFKLMKKITRIAKQQGMTISCDLNYRAQLWDFQTARDKMSELLPDVDIIFGYEPLNLINIATGEDKKDTLSRNPSLDDLRPILKEIHELYDLRYIAFTQRKIFNHKRNRLQSFISTTHEMVKSPCVDVEILERVGTGDAFSVGVLYGLIQQWSLQETVNFGLKNMCYKHTIHGDYCYATLDEVQSMQFNGSDINR
>NZ_LS483304.1|WP_039643697.1|239953_241357_+|MFS-transporter
MTSQITLNDQKKLKKFQKIDAPILKFKEKLAYGFGDLGNGLMFDMGMIYLLKFYTDILGISAFYGGLVFLVAKVFDAFEDTGVGTIVDSRRNIGPKGKFRPFILYGTVPLALLTVLSFISPDLSYTGKVVWAFATYMLFNMAYSVVNIPYGSLSASMSLNSEDRTQLSVFRNMGSQGALFFAGIVVIPMVDRFSNHTVGYPIVVAVLSVIGVALHLICYKGVKERYVVQREEVKGTNKRAFLGLLKNEAFAVLAIYTLLTIMALFLKQSVQLYYFEYVMGYPNLVGLVSTLNFAVLFPALYLTTILSKKFGKKATALIGVGGFIIFEFLNYAFFGEQLVSFLIVSTISSFFLVIPNTVTWAFIADVVEYGQWKSGIRSEGIIYSSYSFTRKVSQALAGFVPGVALTVIGYQPNVQQAAETLHGLRFLFFVIPAGASLIALLIFLFFYPLTDRKHKQIVKELTLREEV

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Crispr_ID: NZ_LS483304_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LS483304_2

1141739-1141846

Orphan

Consensus_repeat	Method
GTGGGTTCGATTCCCATCAGCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_LS483304_2

>merge|NZ_LS483304|2|1141739-1141846|CRISPRCasFinder
GTGGGTTCGATTCCCATCAGCCGCCCATATCGCTAAATGCGGGTGTAGTTTAATGGCAAAACCTCAGCCTTCCAAGCTGATGTTGTGGGTTCGATTCCCATCACCCGC

>NZ_LS483304|2|2|1141739-1141846|CRISPRCasFinder
GTGGGTTCGATTCCCATCAGCCGC	CCATATCGCTAAATGCGGGTGTAGTTTAATGGCAAAACCTCAGCCTTCCAAGCTGATGTT
GTGGGTTCGATTCCCATCACCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LS483304.1\|WP_039645129.1\|1139055_1140459_+\|protoporphyrinogen-oxidase	unknown	unknown	gnl\|CDD\|237009
NZ_LS483304.1\|WP_039645127.1\|1138118_1139042_+\|ferrochelatase	unknown	unknown	gnl\|CDD\|183526
NZ_LS483304.1\|WP_039645130.1\|1140541_1141096_+\|serine-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|226075
NZ_LS483304.1\|WP_039645122.1\|1136325_1136856_-\|signal-transduction-protein-TRAP	unknown	unknown	gnl\|CDD\|225209
NZ_LS483304.1\|WP_039645132.1\|1143426_1143657_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LS483304.1\|WP_158484652.1\|1142468_1143062_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271189
NZ_LS483304.1\|WP_039645120.1\|1135063_1136278_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|377581
NZ_LS483304.1\|WP_052257824.1\|1143148_1143361_-\|Arm-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|373198
NZ_LS483304.1\|WP_039645125.1\|1137052_1138096_+\|uroporphyrinogen-decarboxylase	unknown	unknown	gnl\|CDD\|234644
NZ_LS483304.1\|WP_158484654.1\|1146215_1146353_+\|hypothetical-protein	unknown	unknown	unknown
NZ_LS483304.1\|WP_039645140.1\|1150441_1150684_+\|DUF2273-domain-containing-protein	unknown	unknown	gnl\|CDD\|227834
NZ_LS483304.1\|WP_039645114.1\|1133336_1133693_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227313
NZ_LS483304.1\|WP_039645112.1\|1132706_1133237_-\|HTH-type-transcriptional-regulator-Hpr	unknown	unknown	gnl\|CDD\|237501
NZ_LS483304.1\|WP_039645137.1\|1148609_1149461_+\|PrsW-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|379143
NZ_LS483304.1\|WP_052257825.1\|1143724_1144801_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LS483304.1\|WP_039645135.1\|1147051_1147915_+\|PrsW-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|379143
NZ_LS483304.1\|WP_039645116.1\|1133772_1134201_-\|HIT-family-protein	unknown	unknown	gnl\|CDD\|223611
NZ_LS483304.1\|WP_039645118.1\|1134329_1135067_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_LS483304.1\|WP_039645139.1\|1149875_1150421_+\|alkaline-shock-response-membrane-anchor-protein-AmaP	unknown	unknown	gnl\|CDD\|380217
NZ_LS483304.1\|WP_111725042.1\|1142329_1142482_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|271189

Protein	Function_ID	Function_description	E-value
NZ_LS483304.1\|WP_039645129.1\|1139055_1140459_+\|protoporphyrinogen-oxidase	gnl\|CDD\|237009	PRK11883, PRK11883, protoporphyrinogen oxidase; Reviewed.	0
NZ_LS483304.1\|WP_039645127.1\|1138118_1139042_+\|ferrochelatase	gnl\|CDD\|183526	PRK12435, PRK12435, ferrochelatase; Provisional.	0
NZ_LS483304.1\|WP_039645130.1\|1140541_1141096_+\|serine-hydrolase-family-protein	gnl\|CDD\|226075	COG3545, COG3545, Predicted esterase of the alpha/beta hydrolase fold [General function prediction only].	1.30816e-33
NZ_LS483304.1\|WP_039645122.1\|1136325_1136856_-\|signal-transduction-protein-TRAP	gnl\|CDD\|225209	COG2329, COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only].	0.00310768
NZ_LS483304.1\|WP_039645135.1\|1147051_1147915_+\|PrsW-family-intramembrane-metalloprotease	gnl\|CDD\|379143	pfam13367, PrsW-protease, Protease prsW family. This is a family of putative peptidases, possibly belonging to the MEROPS M79 family. PrsW, appears to be a member of a widespread family of membrane proteins that includes at least one previously known protease. PrsW appears to be responsible for Site-1 cleavage of the RsiW anti-sigma factor, the cognate anti-sigma factor, and it senses antimicrobial peptides that damage the cell membrane and other agents that cause cell envelope stress, The three acidic residues, E75, E76 and E95 in Aflv_1074, appear to be crucial since their mutation to alanine renders the protein inactive. Based on predictions of the bioinformatics programme TMHMM it is likely that these residues are located on the extracytoplasmic face of PrsW placing them in a position to act as a sensor for cell envelope stress.	1.82919e-09
NZ_LS483304.1\|WP_158484652.1\|1142468_1143062_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.07905e-10
NZ_LS483304.1\|WP_039645120.1\|1135063_1136278_+\|ABC-transporter-permease	gnl\|CDD\|377581	pfam05975, EcsB, Bacterial ABC transporter protein EcsB. This family consists of several bacterial ABC transporter proteins which are homologous to the EcsB protein of Bacillus subtilis. EcsB is thought to encode a hydrophobic protein with six membrane-spanning helices in a pattern found in other hydrophobic components of ABC transporters.	1.47167e-70
NZ_LS483304.1\|WP_052257824.1\|1143148_1143361_-\|Arm-DNA-binding-domain-containing-protein	gnl\|CDD\|373198	pfam14657, Arm-DNA-bind_4, Arm DNA-binding domain. This family includes AP2-like domains found in a variety of phage integrase proteins. These domains bind to Arm DNA sites.	0.00325771
NZ_LS483304.1\|WP_039645125.1\|1137052_1138096_+\|uroporphyrinogen-decarboxylase	gnl\|CDD\|234644	PRK00115, hemE, uroporphyrinogen decarboxylase; Validated.	0
NZ_LS483304.1\|WP_039645114.1\|1133336_1133693_-\|hypothetical-protein	gnl\|CDD\|227313	COG4980, GvpP, Gas vesicle protein [General function prediction only].	4.04339e-12
NZ_LS483304.1\|WP_039645112.1\|1132706_1133237_-\|HTH-type-transcriptional-regulator-Hpr	gnl\|CDD\|237501	PRK13777, PRK13777, HTH-type transcriptional regulator Hpr.	5.18061e-57
NZ_LS483304.1\|WP_039645137.1\|1148609_1149461_+\|PrsW-family-intramembrane-metalloprotease	gnl\|CDD\|379143	pfam13367, PrsW-protease, Protease prsW family. This is a family of putative peptidases, possibly belonging to the MEROPS M79 family. PrsW, appears to be a member of a widespread family of membrane proteins that includes at least one previously known protease. PrsW appears to be responsible for Site-1 cleavage of the RsiW anti-sigma factor, the cognate anti-sigma factor, and it senses antimicrobial peptides that damage the cell membrane and other agents that cause cell envelope stress, The three acidic residues, E75, E76 and E95 in Aflv_1074, appear to be crucial since their mutation to alanine renders the protein inactive. Based on predictions of the bioinformatics programme TMHMM it is likely that these residues are located on the extracytoplasmic face of PrsW placing them in a position to act as a sensor for cell envelope stress.	4.48998e-10
NZ_LS483304.1\|WP_039645140.1\|1150441_1150684_+\|DUF2273-domain-containing-protein	gnl\|CDD\|227834	COG5547, COG5547, Small integral membrane protein [Function unknown].	1.07821e-15
NZ_LS483304.1\|WP_039645116.1\|1133772_1134201_-\|HIT-family-protein	gnl\|CDD\|223611	COG0537, Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only].	5.70919e-53
NZ_LS483304.1\|WP_039645118.1\|1134329_1135067_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	5.83181e-87
NZ_LS483304.1\|WP_039645139.1\|1149875_1150421_+\|alkaline-shock-response-membrane-anchor-protein-AmaP	gnl\|CDD\|380217	NF033218, anchor_AmaP, alkaline shock response membrane anchor protein AmaP. The founding member of this family, AmaP (Asp23 membrane anchoring protein), is related to Asp23 through part of its length, but includes a highly hydrophobic N-terminal region that should make it an integral membrane protein. Asp23 (alkaline shock protein of 23 kDa), described in PMID:7864904, is a cytosolic protein in Staphylococcus aureus, strongly induced by a pH shift from 7 to 10, and also recruited to the membrane. AmaP appears to be the partner protein with an integral membrane segment and the ability to anchor Asp23 to the membrane. This model was built to identify full-length homologs of AmaP, while excluding Asp23. Some but not all members of this family score above the cutoffs of Pfam model version PF03780.11, but full-length homologs of Asp23 score considerably higher. Asp23 family members previously were known as DUF322.	2.05788e-37
NZ_LS483304.1\|WP_111725042.1\|1142329_1142482_-\|hypothetical-protein	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.41982e-08

>NZ_LS483304.1|WP_039645130.1|1140541_1141096_+|serine-hydrolase-family-protein
MTQVYIAHGYHADPNQHWFQWLKNVLEIEGHDVKVIKFPNPDTPQIDEWLDAMRKQVTQLNHDTLFVAHSLGVITTLKFLYDADISSIGGVALVSGFKDRLPHMPELNEFVDQSIDYKSLKLKLNHRFCIAAKNDTIVPFSYTAKLSDVLGAKLYVKEEGGHFCQEDGFESFNFLKQKIIQKLD
>NZ_LS483304.1|WP_039645129.1|1139055_1140459_+|protoporphyrinogen-oxidase
MTKVAIIGAGITGLSSAFFIKKHYPDVDITIYEASDVPGGKIKTVTRDGYTIELGPESYLGRKTIMTDVAKEVGILEKDIITNHTGQSFIFARNQLYPVPGGSILGIPTDIKPFITTKLISFKGKIRALKDLTRKPIPMKDDISVGAFFRYRLGDEILENLIEPLLSGIYGTDIDQLSLMSTFPNFKTLEETHGSIMKGMQNVRLHREQKEQHNTEGPQGQFKQFRHGLYHFISQLEEWLMNHHVQFKYNTPVKDLIGEQKGYNVVTSNETSTFFDGVIVTTPHHVFHKWFETDPGFDYFKKLEASSVATIVLGFDEKNIKNTHDGTGFVIARTSNTSITACTWTTKKWPHTTPKGKVLIRAYIGKPGDDIVKTRSDEELIAIAKKDLSKMMTFYGEPDFTIVNKMIDASPQYHVGHIHNIKRIQEHIYKEYPHLQITGAPFEAVGLPDCIQQAQDAVQRLIPRIQT
>NZ_LS483304.1|WP_039645127.1|1138118_1139042_+|ferrochelatase
MKKEVGLLVMAYGTPYQKSDIEPYYTDIRRGRKPSEEELNDLVSRYEAIGGLSPLAKITERQAKAICETLNEQQSDVTYRLYIGLKHIHPFIEDAITDMYRDGITEAVTVVLAPHFSNFSIGSYDKRADKKAAEFGIQLRHVEHYYDQSKFIEYWTMRINEILANIPQEEHDKTMLIVSAHSLPEKMIIESNDPYPKELENTALALKEQSAIKHVAIGWQSEGNTGTPWLGPDVQDLTRELYHQKQYQHFIYTPVGFVAEHLEVLYDNDYECRVVCEELGAMYHRPPMPDTHPLFIGAIVDEISKLG
>NZ_LS483304.1|WP_039645125.1|1137052_1138096_+|uroporphyrinogen-decarboxylase
MVTPFNDTILKAIKGEQIKHTPVWFMRQAGRSQPEYRKLKEKYSLFEITHQPELCAYVTALPVEQYDTDAAVLYKDIMTPLKAIGVDVDIKSGIGPVIANPIRQMSDVEQLGQIDPKRDVPYVLDTIKLLTSEKLNVPLIGFTGAPFTLASYMIEGGPSKNYNKTKALMYSDEATWFKLMDTLSDMSITYVGAQVEAGAQLIQVFDSWVGALNQADYDYYIKPCMDKLVAGIKAFNIPVILFGVGASHLITSWNALPIDVLGLDWRTSIKEAEALGVKKTVQGNLDPSILLAPWAVIEERLKPILDQGLAHGTHIFNLGHGVFPEVKPETLQRVSKFVHDYTGEKLK
>NZ_LS483304.1|WP_039645122.1|1136325_1136856_-|signal-transduction-protein-TRAP
MKLYITYGTYGYIHQIQLNNKDRKLLIFSSDDRSVLIDETEKESVFQQPNAFRSLSRVGDISENDFQAVISIPTSEDHKYQLEKKLDAYYPTLSDFEGYKSFRLLKPLKENVYKVMFGFESRTAYEDFKKSSVFRENFSKEAVRSLAGVTSAHSSYLERYFYPISEEDIINQEQYE
>NZ_LS483304.1|WP_039645120.1|1135063_1136278_+|ABC-transporter-permease
MNNVKALYRSRQRKDFEEKRYYNKFIFNGHFSVFLVILLGAFILGYGEWLRAIPKGINYLLIMSILLSLTSLFPLKTRLLEADQLFLLPFENNMMYYMKRCVLSSYLSRLPLHIIMLIIFYPLFHTLYPNDTLHFIVLIILALFLPFLGLMLRWQWYLYGLENWSINLLLFILILSGYYVWIDGKSYMGLASVLFIIGLIILLKNMNTKKRFPWYFMVNQAHQHQANYYKFVNMFTDVKGLTAPSSRRKYLDVFLRKPKQMTSDTMYLYLFKRHFLRGKDAFHLTLRLGIIVASLMIWLHQPIVSLIIGSLGMYIIILQMSQFYTQEAYGIWPQVWPVSDLKVIQGYQTFLYHTVVVVGIVLSLTFMISNLQYAYAVVVFFIVGILTVRATIKKLKYQETLLRD
>NZ_LS483304.1|WP_039645118.1|1134329_1135067_+|ABC-transporter-ATP-binding-protein
MTVQVTNLTGGYGKTPIIKNINFSLKPGEIVGLIGLNGAGKSTTIKHLLGLLTPTEGEMSISNININDDIEAYRRRLSYIPESPVIYDTLTLKEHIEMTAMAYNIDVNTAMTRAIPLLKSFRLEDQLDIFPSHFSKGMKQKVMIICAFIVDPDLYIIDEPFLGLDPLGIQAMLDLMESKKHEGRTVLMSTHILATAERYCDRFIILDQGQIVAMGDLDELRQQTQMPNHTLDEIYIKVTHQGASL
>NZ_LS483304.1|WP_039645116.1|1133772_1134201_-|HIT-family-protein
MAETIFSKIIDGDIPSFKVYENDYVYAFLDISQLSKGHTLLIPKKPSANIYETDAETMKHIGEALPIVANAIKEAFNPDGLNIVQNNGEYASQSVFHIHFHLIPRYKNDIDGFEYHWETHEDVFNDEAKASIAKQIANKIQQ
>NZ_LS483304.1|WP_039645114.1|1133336_1133693_-|hypothetical-protein
MRALQITLGLAAGVATGLGVALMKRDSGTRIESTTVEKPKSDLEKEINNIKRSFSDILSYVNDIKTESQTVAGSIGDEVKTMIGEFQSDIDPNFKRLQSHIENLQNRGEEITNFPSKK
>NZ_LS483304.1|WP_039645112.1|1132706_1133237_-|HTH-type-transcriptional-regulator-Hpr
MTDKQKQIESILFTHKAAMLSKVIWKNAERDWQNWLRKSGITMNEHLILMTIYAFGRVTISDISRYGVMHVSTAYNFAKRLEQQGLLTLEKDTNDKRNTYIHLTDNGKKLIEEIFEQYNIDNNTVYQASEQFSEEMFHKPNFSDAHYLVAKMHGKDFIDDVNACHNHLRKHLLDVE
>NZ_LS483304.1|WP_111725042.1|1142329_1142482_-|hypothetical-protein
MLIHNGISIYYISKRLGHADITTTLSIYSHLLEETKSVEENKTLKALRSM
>NZ_LS483304.1|WP_158484652.1|1142468_1143062_-|tyrosine-type-recombinase/integrase
MNYQELINDYAETHTSESVRKLNYCLRSALSDAFYEGMIAKDPTYKVIVQCKKEAQAEGDKFMQLSYFYKLKEFSKEKEQLSYLFIYLCIVTGARFSEVQKLKYQDLNLTDETVHIRGTKTKNADRIIKITKEDIKHVRKVLNNFPNNIQGNIFTTGANLITHNTVTNVLQRFCIENKLGNYHTAFPKTYPLLNANS
>NZ_LS483304.1|WP_052257824.1|1143148_1143361_-|Arm-DNA-binding-domain-containing-protein
MYVTKRGNKWQYDFRLNGKRHRKSGFKTKKEAIQAMNATYNTLNKGNNLSSDMPFIDFLKTGLKFTKPPI
>NZ_LS483304.1|WP_039645132.1|1143426_1143657_-|hypothetical-protein
MKFNNWNIIFEGKDDYDILTNDNKIILIQNFENVEAALIVNDNSVQIKQVGYTNDITIKAETKEIVINVVDVFDEE
>NZ_LS483304.1|WP_052257825.1|1143724_1144801_-|hypothetical-protein
MKFKLLAGLMFICLVLLSACGMSEEDKEKKFSDATKKYVKDITKTFKKIDEIKSEDPNVISKEAKKASKEIDKSYKDYKQEVDKELLKDYYDREELDKTFKYIYEIYSDLYMRLDNVGSIDGVSKEAYFKIAVKDIYIAQESLGNLKVNIENVETRKILGKEQNNNLYNILHTKEEEQEELIKAFALLQNKNHIINDTDKIPKRDMVKLNKYSKNNHTRTVSAAEFNELVDEVNKRLDKDSQISRVDDEVNVYVYNILMEINNVLTEVHNEEVEARDNAEMAKYEAMEDEAESDINSSEFEGTSEESDSDSKQSAREAELEKEYFDLSDKMNQDGVSDTDLKSMEQRQNGILDEVKPY
>NZ_LS483304.1|WP_158484654.1|1146215_1146353_+|hypothetical-protein
MIDVKYYTDIEITHFISIGELELHKVRKDEIKTIEKLFKPNLFML
>NZ_LS483304.1|WP_039645135.1|1147051_1147915_+|PrsW-family-intramembrane-metalloprotease
MKKFLKKYKYHALVIFAVWSFISGFKLYYTNFGKPNGFEEKYPLFLLNIALIAIYAIPLILLARYLTKRFEISKKVVTLSWIMGLTASLYLSGIGHLFVALFWIKVINPPQSFINQWGAAVSGPFAEEFGKGLTVLIILLLFKKMDLKHALVSGMIVGLSFQIIEDCIFTFRNVFVANGEGFATLIERIVHAGGTHWTFSILFAVGMVALIAKNTGFSKIQGVFWLIMGIFAHFLVNSPFNDGIDSKTGEVTVLILTFNLCLAIAAIKSVDKIESKKTEDACQEKTK
>NZ_LS483304.1|WP_039645137.1|1148609_1149461_+|PrsW-family-intramembrane-metalloprotease
MKNLFNKYKYHALILFAIWSFFSGCRIFYESFGKPNGLEDKYPLFLLNIALIAIYAIPLILLTRYLAKRFEISKKVIQLSWVMALTASVYFSDIGHTIVGYTTIVILKVPNAILADWGAAISGPLAEEFGKGFAVLLVLLILKKMDLKNALVSGMIIGLGFQIIEDCYFTFQEIFKAKADGFSLLLERIAFAGGTHWVFTLIFAIGIVALIAKDTGISKIQGLVWMLVAYFAHFIYNTPFNNGIGSSTGDFTVLLLTINLSLALLAFKTVDKIVSQQKGQLPN
>NZ_LS483304.1|WP_039645139.1|1149875_1150421_+|alkaline-shock-response-membrane-anchor-protein-AmaP
MKRLKNFILGLLIVVIVGFLLFMYIDHQSIKQYQNYFYQFNWFQPLLIGLAGLLILIGLILFFSAFKPTHRKPGLYKDYSDGHIYVSRKSIENTVYDTLKQYDDIRQPNVISKLYNKKNHSYIDIKADYLVPTSTTNVQTLNEKIRNDIKERVEHFAEIPVRNLEINVRDQRKSSNEPRVV
>NZ_LS483304.1|WP_039645140.1|1150441_1150684_+|DUF2273-domain-containing-protein
MNNNENHQSHQAAVDTLAIFFRAYQWRIIGFFLFLILAILFITLGFWKTILIAFLCLVGIGLGYIKDRTQDFLNFINRIS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_LS483304_1	1.11\|226466\|29\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	226466-226494	29	NZ_KT373969	Staphylococcus pseudintermedius strain HR547/11 plasmid pKM01, complete sequence	27290-27318	1	0.966
NZ_LS483304_1	1.12\|226531\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	226531-226560	30	MT724048	Staphylococcus phage SAP3, partial genome	7624-7653	1	0.967
NZ_LS483304_1	1.8\|226268\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	226268-226297	30	NZ_CP046030	Staphylococcus chromogenes strain 1401 plasmid unnamed2, complete sequence	9359-9388	2	0.933
NZ_LS483304_1	1.14\|226663\|29\|NZ_LS483304\|CRISPRCasFinder	226663-226691	29	NZ_CP026963	Staphylococcus aureus strain FDAARGOS_6 plasmid unnamed1	60704-60732	3	0.897
NZ_LS483304_1	1.2\|225871\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	225871-225900	30	MT774389	CrAssphage cr116_1, complete genome	1385-1414	6	0.8
NZ_LS483304_1	1.13\|226597\|30\|NZ_LS483304\|CRISPRCasFinder,CRT	226597-226626	30	NZ_CP033067	Pseudoalteromonas agarivorans strain Hao 2018 plasmid unnamed, complete sequence	3980-4009	6	0.8
NZ_LS483304_1	1.13\|226597\|30\|NZ_LS483304\|CRISPRCasFinder,CRT	226597-226626	30	HM246721	Campylobacter phage vB_CcoM-IBB_35 clone Contig2, complete sequence	4982-5011	6	0.8
NZ_LS483304_1	1.13\|226597\|30\|NZ_LS483304\|CRISPRCasFinder,CRT	226597-226626	30	NC_019507	Campylobacter phage CP21, complete genome	132639-132668	6	0.8
NZ_LS483304_1	1.13\|226597\|30\|NZ_LS483304\|CRISPRCasFinder,CRT	226597-226626	30	MT932329	Campylobacter phage F379, complete genome	11194-11223	6	0.8
NZ_LS483304_1	1.13\|226597\|30\|NZ_LS483304\|CRISPRCasFinder,CRT	226597-226626	30	HE815464	Campylobacter phage CP21 complete sequence	132639-132668	6	0.8
NZ_LS483304_1	1.13\|226597\|30\|NZ_LS483304\|CRISPRCasFinder,CRT	226597-226626	30	FN667788	Campylobacter phage CP220, complete genome	37317-37346	6	0.8
NZ_LS483304_1	1.1\|225805\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	225805-225834	30	NZ_CP032858	Bacillus subtilis subsp. subtilis strain 2RL2-3 plasmid unnamed1, complete sequence	36010-36039	7	0.767
NZ_LS483304_1	1.1\|225805\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	225805-225834	30	NZ_CP032873	Bacillus subtilis subsp. subtilis strain 2KL1 plasmid unnamed1, complete sequence	57045-57074	7	0.767
NZ_LS483304_1	1.1\|225805\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	225805-225834	30	NZ_CP026534	Bacillus velezensis strain DKU_NT_04 plasmid p1_DKU_NT_04, complete sequence	95370-95399	7	0.767
NZ_LS483304_1	1.2\|225871\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	225871-225900	30	AP014283	Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S23-C59, * SEQUENCING IN PROGRESS *	5990-6019	7	0.767
NZ_LS483304_1	1.7\|226202\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	226202-226231	30	KY389064	Staphylococcus phage phi879, complete genome	18882-18911	7	0.767
NZ_LS483304_1	1.7\|226202\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	226202-226231	30	KY389063	Staphylococcus phage phi575, complete genome	20507-20536	7	0.767
NZ_LS483304_1	1.7\|226202\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	226202-226231	30	NZ_CP021150	Vibrio campbellii strain LA16-V1 plasmid pLA16-4, complete sequence	58591-58620	7	0.767
NZ_LS483304_1	1.7\|226202\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	226202-226231	30	NZ_CP023526	Cedecea neteri strain FDAARGOS_392 plasmid unnamed, complete sequence	224086-224115	7	0.767
NZ_LS483304_1	1.7\|226202\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	226202-226231	30	NZ_CP034296	Vibrio parahaemolyticus strain 20140829008-1 plasmid pVPGD2014-1, complete sequence	2989-3018	7	0.767
NZ_LS483304_1	1.7\|226202\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	226202-226231	30	NZ_CP034567	Vibrio parahaemolyticus strain D3112 plasmid p1, complete sequence	65949-65978	7	0.767
NZ_LS483304_1	1.7\|226202\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	226202-226231	30	NZ_CP034568	Vibrio parahaemolyticus strain D3112 plasmid p2, complete sequence	17295-17324	7	0.767
NZ_LS483304_1	1.7\|226202\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	226202-226231	30	NZ_CP034291	Vibrio parahaemolyticus strain 20140722001-1 plasmid pVPCZ2014-1, complete sequence	98661-98690	7	0.767
NZ_LS483304_1	1.7\|226202\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	226202-226231	30	NZ_CP034287	Vibrio parahaemolyticus strain 20140624012-1 plasmid pVPHB2014-1, complete sequence	45788-45817	7	0.767
NZ_LS483304_1	1.12\|226531\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	226531-226560	30	AP013555	Uncultured Mediterranean phage uvMED isolate uvMED-CGR-C28-MedDCM-OCT-S32-C50, * SEQUENCING IN PROGRESS *, 2 ordered pieces	17992-18021	7	0.767
NZ_LS483304_1	1.13\|226597\|30\|NZ_LS483304\|CRISPRCasFinder,CRT	226597-226626	30	KM389416	UNVERIFIED: Staphylococcus phage Phi06_3106 B clone contig00001 genomic sequence	18326-18355	7	0.767
NZ_LS483304_1	1.13\|226597\|30\|NZ_LS483304\|CRISPRCasFinder,CRT	226597-226626	30	MK290764	Staphylococcus virus B122, complete genome	27628-27657	7	0.767
NZ_LS483304_1	1.13\|226597\|30\|NZ_LS483304\|CRISPRCasFinder,CRT	226597-226626	30	KM389280	UNVERIFIED: Staphylococcus phage Phi06_2986 B clone contig00001 genomic sequence	24289-24318	7	0.767
NZ_LS483304_1	1.13\|226597\|30\|NZ_LS483304\|CRISPRCasFinder,CRT	226597-226626	30	KP893289	Staphylococcus phage B166, complete genome	27399-27428	7	0.767
NZ_LS483304_1	1.2\|225871\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	225871-225900	30	NZ_CP013615	Clostridium perfringens strain JP838 plasmid pJFP838A, complete sequence	324293-324322	8	0.733
NZ_LS483304_1	1.2\|225871\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	225871-225900	30	NZ_CP033099	Staphylococcus warneri strain SWO plasmid unnamed1, complete sequence	12957-12986	8	0.733
NZ_LS483304_1	1.2\|225871\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	225871-225900	30	NZ_CP033099	Staphylococcus warneri strain SWO plasmid unnamed1, complete sequence	17174-17203	8	0.733
NZ_LS483304_1	1.2\|225871\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	225871-225900	30	MH617354	Microviridae sp. isolate ctda10, complete genome	2106-2135	8	0.733
NZ_LS483304_1	1.3\|225937\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	225937-225966	30	MH937482	Streptococcus phage CHPC982, partial genome	3139-3168	8	0.733
NZ_LS483304_1	1.3\|225937\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	225937-225966	30	NC_018516	Bacillus thuringiensis HD-789 plasmid pBTHD789-1, complete sequence	8645-8674	8	0.733
NZ_LS483304_1	1.3\|225937\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	225937-225966	30	NZ_CP009334	Bacillus thuringiensis strain HD1011 plasmid 2, complete sequence	292440-292469	8	0.733
NZ_LS483304_1	1.3\|225937\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	225937-225966	30	NZ_CP053970	Bacillus thuringiensis strain FDAARGOS_796 plasmid unnamed2, complete sequence	72205-72234	8	0.733
NZ_LS483304_1	1.3\|225937\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	225937-225966	30	NZ_CP053979	Bacillus thuringiensis strain FDAARGOS_795 plasmid unnamed3, complete sequence	330018-330047	8	0.733
NZ_LS483304_1	1.3\|225937\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	225937-225966	30	NZ_CP013277	Bacillus thuringiensis serovar israelensis strain AM65-52 plasmid pAM65-52-2-350K, complete sequence	198739-198768	8	0.733
NZ_LS483304_1	1.3\|225937\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	225937-225966	30	NZ_CP039723	Bacillus thuringiensis strain BT-59 plasmid p2, complete sequence	315742-315771	8	0.733
NZ_LS483304_1	1.3\|225937\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	225937-225966	30	NZ_CP009348	Bacillus thuringiensis HD1002 plasmid 2, complete sequence	198740-198769	8	0.733
NZ_LS483304_1	1.3\|225937\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	225937-225966	30	NZ_CP045024	Bacillus thuringiensis strain JW-1 plasmid p2, complete sequence	198249-198278	8	0.733
NZ_LS483304_1	1.5\|226069\|31\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	226069-226099	31	NZ_CP045331	Labrenzia sp. THAF191b plasmid pTHAF191b_c, complete sequence	2610-2640	8	0.742
NZ_LS483304_1	1.5\|226069\|31\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	226069-226099	31	NZ_CP045347	Labrenzia sp. THAF187b plasmid pTHAF187b_c, complete sequence	50832-50862	8	0.742
NZ_LS483304_1	1.5\|226069\|31\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	226069-226099	31	NZ_CP045336	Labrenzia sp. THAF191a plasmid pTHAF191a_c, complete sequence	28030-28060	8	0.742
NZ_LS483304_1	1.7\|226202\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	226202-226231	30	MT133560	Pseudomonas phage fnug, complete genome	95250-95279	8	0.733
NZ_LS483304_1	1.7\|226202\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	226202-226231	30	NZ_AP022558	Geobacillus subterraneus strain E55-1 plasmid pGspE55-1, complete sequence	3205-3234	8	0.733
NZ_LS483304_1	1.7\|226202\|30\|NZ_LS483304\|PILER-CR,CRISPRCasFinder,CRT	226202-226231	30	NC_042081	Pseudomonas phage SL2, complete genome	191655-191684	8	0.733
NZ_LS483304_2	2.1\|1141763\|60\|NZ_LS483304\|CRISPRCasFinder	1141763-1141822	60	NC_020451	Vibrio coralliilyticus strain ATCC BAA-450 plasmid, complete sequence	1965-2024	8	0.867
NZ_LS483304_2	2.1\|1141763\|60\|NZ_LS483304\|CRISPRCasFinder	1141763-1141822	60	NZ_CP024037	Bacillus aryabhattai strain K13 plasmid unnamed2	10422-10481	10	0.833
NZ_LS483304_2	2.1\|1141763\|60\|NZ_LS483304\|CRISPRCasFinder	1141763-1141822	60	NZ_CP026740	Bacillus megaterium strain YC4-R4 plasmid unnamed4	70769-70828	10	0.833
NZ_LS483304_2	2.1\|1141763\|60\|NZ_LS483304\|CRISPRCasFinder	1141763-1141822	60	NZ_CP010587	Bacillus megaterium Q3 plasmid p1, complete sequence	833-892	10	0.833
NZ_LS483304_2	2.1\|1141763\|60\|NZ_LS483304\|CRISPRCasFinder	1141763-1141822	60	NZ_CP023319	Bacillus megaterium strain A plasmid p2, complete sequence	75820-75879	10	0.833
NZ_LS483304_2	2.1\|1141763\|60\|NZ_LS483304\|CRISPRCasFinder	1141763-1141822	60	NZ_CP015439	Anoxybacillus amylolyticus strain DSM 15939 plasmid pDSM15939_1, complete sequence	255882-255941	10	0.833
NZ_LS483304_2	2.1\|1141763\|60\|NZ_LS483304\|CRISPRCasFinder	1141763-1141822	60	NC_017139	Bacillus megaterium WSH-002 plasmid WSH-002_p1, complete sequence	1323-1382	10	0.833
NZ_LS483304_2	2.1\|1141763\|60\|NZ_LS483304\|CRISPRCasFinder	1141763-1141822	60	NC_004604	Bacillus megaterium QM B1551 plasmid pBM400, complete sequence	46415-46474	11	0.817
NZ_LS483304_2	2.1\|1141763\|60\|NZ_LS483304\|CRISPRCasFinder	1141763-1141822	60	NZ_CP015440	Anoxybacillus amylolyticus strain DSM 15939 plasmid pDSM15939_2, complete sequence	64778-64837	11	0.817
NZ_LS483304_2	2.1\|1141763\|60\|NZ_LS483304\|CRISPRCasFinder	1141763-1141822	60	NZ_CP033045	Bacillus foraminis strain Bac44 plasmid unnamed, complete sequence	483786-483845	11	0.817
NZ_LS483304_2	2.1\|1141763\|60\|NZ_LS483304\|CRISPRCasFinder	1141763-1141822	60	NZ_CP041068	Bacillus megaterium strain KNU-01 plasmid pKNU_01_4, complete sequence	36186-36245	13	0.783
NZ_LS483304_2	2.1\|1141763\|60\|NZ_LS483304\|CRISPRCasFinder	1141763-1141822	60	NZ_CP032535	Bacillus megaterium NCT-2 plasmid pNCT2_7, complete sequence	36094-36153	13	0.783
NZ_LS483304_2	2.1\|1141763\|60\|NZ_LS483304\|CRISPRCasFinder	1141763-1141822	60	CP041516	Bacillus aryabhattai strain KNU10 plasmid unnamed, complete sequence	17875-17934	13	0.783
NZ_LS483304_2	2.1\|1141763\|60\|NZ_LS483304\|CRISPRCasFinder	1141763-1141822	60	CP031730	Stenotrophomonas rhizophila strain GA1 plasmid unnamed1, complete sequence	5218-5277	15	0.75

1. spacer 1.11|226466|29|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_KT373969 (Staphylococcus pseudintermedius strain HR547/11 plasmid pKM01, complete sequence) position: , mismatch: 1, identity: 0.966

tttggtagccatttacttcacaagagagg	CRISPR spacer
tttggtagccatttacttaacaagagagg	Protospacer
****************** **********

2. spacer 1.12|226531|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to MT724048 (Staphylococcus phage SAP3, partial genome) position: , mismatch: 1, identity: 0.967

gaatatgtaggttctaatatactgtcacct	CRISPR spacer
gaatatgtaggttctaatatactatcacct	Protospacer
***********************.******

3. spacer 1.8|226268|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP046030 (Staphylococcus chromogenes strain 1401 plasmid unnamed2, complete sequence) position: , mismatch: 2, identity: 0.933

ttgataacttcggtttaggtgattttatca	CRISPR spacer
ttgataactttggtttaggtgattttatta	Protospacer
**********.*****************.*

4. spacer 1.14|226663|29|NZ_LS483304|CRISPRCasFinder matches to NZ_CP026963 (Staphylococcus aureus strain FDAARGOS_6 plasmid unnamed1) position: , mismatch: 3, identity: 0.897

aaagaatagaattggcgttgtgcgcagat	CRISPR spacer
taagaaaagaatcggcgttgtgcgcagat	Protospacer
 ***** *****.****************

5. spacer 1.2|225871|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to MT774389 (CrAssphage cr116_1, complete genome) position: , mismatch: 6, identity: 0.8

tttagcaacttttttataactatcaccatt	CRISPR spacer
tttagcaacttttttataattatttttagt	Protospacer
*******************.***. ..* *

6. spacer 1.13|226597|30|NZ_LS483304|CRISPRCasFinder,CRT matches to NZ_CP033067 (Pseudoalteromonas agarivorans strain Hao 2018 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.8

agaaatacttgtaaacacagcaagccttgt	CRISPR spacer
taaaatacttgtagacacatcaagcctagc	Protospacer
 .***********.***** ******* *.

7. spacer 1.13|226597|30|NZ_LS483304|CRISPRCasFinder,CRT matches to HM246721 (Campylobacter phage vB_CcoM-IBB_35 clone Contig2, complete sequence) position: , mismatch: 6, identity: 0.8

agaaatacttgtaaacacagcaagccttgt	CRISPR spacer
agctatacttttaaacacagcaaacctttg	Protospacer
**  ****** ************.****

8. spacer 1.13|226597|30|NZ_LS483304|CRISPRCasFinder,CRT matches to NC_019507 (Campylobacter phage CP21, complete genome) position: , mismatch: 6, identity: 0.8

agaaatacttgtaaacacagcaagccttgt	CRISPR spacer
agctatacttttaaacacagcaaaccttta	Protospacer
**  ****** ************.****

9. spacer 1.13|226597|30|NZ_LS483304|CRISPRCasFinder,CRT matches to MT932329 (Campylobacter phage F379, complete genome) position: , mismatch: 6, identity: 0.8

agaaatacttgtaaacacagcaagccttgt	CRISPR spacer
agctatacttttaaacacagcaaaccttta	Protospacer
**  ****** ************.****

10. spacer 1.13|226597|30|NZ_LS483304|CRISPRCasFinder,CRT matches to HE815464 (Campylobacter phage CP21 complete sequence) position: , mismatch: 6, identity: 0.8

agaaatacttgtaaacacagcaagccttgt	CRISPR spacer
agctatacttttaaacacagcaaaccttta	Protospacer
**  ****** ************.****

11. spacer 1.13|226597|30|NZ_LS483304|CRISPRCasFinder,CRT matches to FN667788 (Campylobacter phage CP220, complete genome) position: , mismatch: 6, identity: 0.8

agaaatacttgtaaacacagcaagccttgt	CRISPR spacer
agctatacttttaaacacagcaaaccttta	Protospacer
**  ****** ************.****

12. spacer 1.1|225805|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032858 (Bacillus subtilis subsp. subtilis strain 2RL2-3 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

ttagggtcccaataaatcatttgaccttta	CRISPR spacer
atggcctcccaattagtcatttgacctttc	Protospacer
 *.*  ******* *.*************

13. spacer 1.1|225805|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032873 (Bacillus subtilis subsp. subtilis strain 2KL1 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

ttagggtcccaataaatcatttgaccttta	CRISPR spacer
atggcctcccaattagtcatttgacctttc	Protospacer
 *.*  ******* *.*************

14. spacer 1.1|225805|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP026534 (Bacillus velezensis strain DKU_NT_04 plasmid p1_DKU_NT_04, complete sequence) position: , mismatch: 7, identity: 0.767

ttagggtcccaataaatcatttgaccttta	CRISPR spacer
atggcctcccaattagtcatttgacctttc	Protospacer
 *.*  ******* *.*************

15. spacer 1.2|225871|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to AP014283 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S23-C59, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.767

tttagcaacttttttataactatcaccatt	CRISPR spacer
attctatacttttttataactattacaatt	Protospacer
 **    ****************.** ***

16. spacer 1.7|226202|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to KY389064 (Staphylococcus phage phi879, complete genome) position: , mismatch: 7, identity: 0.767

aactttgacgtacttcaacaatattttact	CRISPR spacer
ctctttgacgaacttcatcaatatttgttt	Protospacer
  ******** ****** ********  .*

17. spacer 1.7|226202|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to KY389063 (Staphylococcus phage phi575, complete genome) position: , mismatch: 7, identity: 0.767

aactttgacgtacttcaacaatattttact	CRISPR spacer
ctctttgacgaacttcatcaatatttgttt	Protospacer
  ******** ****** ********  .*

18. spacer 1.7|226202|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP021150 (Vibrio campbellii strain LA16-V1 plasmid pLA16-4, complete sequence) position: , mismatch: 7, identity: 0.767

aactttgacgtacttcaacaatattttact	CRISPR spacer
gggtttgaggtacttcaccaatatttcatt	Protospacer
.. ***** ******** ********.*.*

19. spacer 1.7|226202|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP023526 (Cedecea neteri strain FDAARGOS_392 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.767

aactttgacgtacttcaacaatattttact	CRISPR spacer
aactttgacgtactgcaagaataatgatgt	Protospacer
************** *** **** *    *

20. spacer 1.7|226202|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP034296 (Vibrio parahaemolyticus strain 20140829008-1 plasmid pVPGD2014-1, complete sequence) position: , mismatch: 7, identity: 0.767

aactttgacgtacttcaacaatattttact	CRISPR spacer
gggtttgaggtacttcaccaatatttcatt	Protospacer
.. ***** ******** ********.*.*

21. spacer 1.7|226202|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP034567 (Vibrio parahaemolyticus strain D3112 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.767

aactttgacgtacttcaacaatattttact	CRISPR spacer
gggtttgaggtacttcaccaatatttcatt	Protospacer
.. ***** ******** ********.*.*

22. spacer 1.7|226202|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP034568 (Vibrio parahaemolyticus strain D3112 plasmid p2, complete sequence) position: , mismatch: 7, identity: 0.767

aactttgacgtacttcaacaatattttact	CRISPR spacer
gggtttgaggtacttcaccaatatttcatt	Protospacer
.. ***** ******** ********.*.*

23. spacer 1.7|226202|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP034291 (Vibrio parahaemolyticus strain 20140722001-1 plasmid pVPCZ2014-1, complete sequence) position: , mismatch: 7, identity: 0.767

aactttgacgtacttcaacaatattttact	CRISPR spacer
gggtttgaggtacttcaccaatatttcatt	Protospacer
.. ***** ******** ********.*.*

24. spacer 1.7|226202|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP034287 (Vibrio parahaemolyticus strain 20140624012-1 plasmid pVPHB2014-1, complete sequence) position: , mismatch: 7, identity: 0.767

aactttgacgtacttcaacaatattttact	CRISPR spacer
gggtttgaggtacttcaccaatatttcatt	Protospacer
.. ***** ******** ********.*.*

25. spacer 1.12|226531|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to AP013555 (Uncultured Mediterranean phage uvMED isolate uvMED-CGR-C28-MedDCM-OCT-S32-C50, *** SEQUENCING IN PROGRESS ***, 2 ordered pieces) position: , mismatch: 7, identity: 0.767

gaatatgtaggttctaatatactgtcacct	CRISPR spacer
ttaattataggttctaatgtactttcacct	Protospacer
  *  *.***********.**** ******

26. spacer 1.13|226597|30|NZ_LS483304|CRISPRCasFinder,CRT matches to KM389416 (UNVERIFIED: Staphylococcus phage Phi06_3106 B clone contig00001 genomic sequence) position: , mismatch: 7, identity: 0.767

agaaatacttgtaaacacagcaagccttgt	CRISPR spacer
agaaatacttgtaaacacaccagctaatgg	Protospacer
******************* **. .  **

27. spacer 1.13|226597|30|NZ_LS483304|CRISPRCasFinder,CRT matches to MK290764 (Staphylococcus virus B122, complete genome) position: , mismatch: 7, identity: 0.767

agaaatacttgtaaacacagcaagccttgt	CRISPR spacer
agaaatacttgtaaacacaccagctaatgg	Protospacer
******************* **. .  **

28. spacer 1.13|226597|30|NZ_LS483304|CRISPRCasFinder,CRT matches to KM389280 (UNVERIFIED: Staphylococcus phage Phi06_2986 B clone contig00001 genomic sequence) position: , mismatch: 7, identity: 0.767

agaaatacttgtaaacacagcaagccttgt	CRISPR spacer
agaaatacttgtaaacacaccagctaatgg	Protospacer
******************* **. .  **

29. spacer 1.13|226597|30|NZ_LS483304|CRISPRCasFinder,CRT matches to KP893289 (Staphylococcus phage B166, complete genome) position: , mismatch: 7, identity: 0.767

agaaatacttgtaaacacagcaagccttgt	CRISPR spacer
agaaatacttgtaaacacaccagctaatgg	Protospacer
******************* **. .  **

30. spacer 1.2|225871|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013615 (Clostridium perfringens strain JP838 plasmid pJFP838A, complete sequence) position: , mismatch: 8, identity: 0.733

tttagcaacttttttataactatcaccatt	CRISPR spacer
cccattaacttttttataccaatcaccatg	Protospacer
...* .************ * ********

31. spacer 1.2|225871|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP033099 (Staphylococcus warneri strain SWO plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

tttagcaacttttttataactatcaccatt	CRISPR spacer
tatagcaccttttttataactatattttat	Protospacer
* ***** ***************  ..  *

32. spacer 1.2|225871|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP033099 (Staphylococcus warneri strain SWO plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

tttagcaacttttttataactatcaccatt	CRISPR spacer
tatagcaccttttttataactatattttat	Protospacer
* ***** ***************  ..  *

33. spacer 1.2|225871|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to MH617354 (Microviridae sp. isolate ctda10, complete genome) position: , mismatch: 8, identity: 0.733

tttagcaacttttttataactatcaccatt	CRISPR spacer
tttagtaacttttttataactcataggaac	Protospacer
*****.***************  .*  * .

34. spacer 1.3|225937|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to MH937482 (Streptococcus phage CHPC982, partial genome) position: , mismatch: 8, identity: 0.733

ggtaaaacaacgtacaagtgaatttgatag	CRISPR spacer
aataagacaacgtacaagtgaattgaaaga	Protospacer
..***.****************** .* ..

35. spacer 1.3|225937|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NC_018516 (Bacillus thuringiensis HD-789 plasmid pBTHD789-1, complete sequence) position: , mismatch: 8, identity: 0.733

ggtaaaacaacgtacaagtgaatttgatag	CRISPR spacer
accaaaacaaggtacaagtgaattcgtaac	Protospacer
. .******* *************.*  *

36. spacer 1.3|225937|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009334 (Bacillus thuringiensis strain HD1011 plasmid 2, complete sequence) position: , mismatch: 8, identity: 0.733

ggtaaaacaacgtacaagtgaatttgatag	CRISPR spacer
accaaaacaaggtacaagtgaattcgtaac	Protospacer
. .******* *************.*  *

37. spacer 1.3|225937|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP053970 (Bacillus thuringiensis strain FDAARGOS_796 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.733

ggtaaaacaacgtacaagtgaatttgatag	CRISPR spacer
accaaaacaaggtacaagtgaattcgtaac	Protospacer
. .******* *************.*  *

38. spacer 1.3|225937|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP053979 (Bacillus thuringiensis strain FDAARGOS_795 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.733

ggtaaaacaacgtacaagtgaatttgatag	CRISPR spacer
accaaaacaaggtacaagtgaattcgtaac	Protospacer
. .******* *************.*  *

39. spacer 1.3|225937|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013277 (Bacillus thuringiensis serovar israelensis strain AM65-52 plasmid pAM65-52-2-350K, complete sequence) position: , mismatch: 8, identity: 0.733

ggtaaaacaacgtacaagtgaatttgatag	CRISPR spacer
accaaaacaaggtacaagtgaattcgtaac	Protospacer
. .******* *************.*  *

40. spacer 1.3|225937|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP039723 (Bacillus thuringiensis strain BT-59 plasmid p2, complete sequence) position: , mismatch: 8, identity: 0.733

ggtaaaacaacgtacaagtgaatttgatag	CRISPR spacer
accaaaacaaggtacaagtgaattcgtaac	Protospacer
. .******* *************.*  *

41. spacer 1.3|225937|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009348 (Bacillus thuringiensis HD1002 plasmid 2, complete sequence) position: , mismatch: 8, identity: 0.733

ggtaaaacaacgtacaagtgaatttgatag	CRISPR spacer
accaaaacaaggtacaagtgaattcgtaac	Protospacer
. .******* *************.*  *

42. spacer 1.3|225937|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP045024 (Bacillus thuringiensis strain JW-1 plasmid p2, complete sequence) position: , mismatch: 8, identity: 0.733

ggtaaaacaacgtacaagtgaatttgatag	CRISPR spacer
accaaaacaaggtacaagtgaattcgtaac	Protospacer
. .******* *************.*  *

43. spacer 1.5|226069|31|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP045331 (Labrenzia sp. THAF191b plasmid pTHAF191b_c, complete sequence) position: , mismatch: 8, identity: 0.742

tgatgccccggtcaagcgttttttgtttgct	CRISPR spacer
tggtgccccggtcaggcgtttttcgatccgg	Protospacer
**.***********.********.* *.

44. spacer 1.5|226069|31|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP045347 (Labrenzia sp. THAF187b plasmid pTHAF187b_c, complete sequence) position: , mismatch: 8, identity: 0.742

tgatgccccggtcaagcgttttttgtttgct	CRISPR spacer
tggtgccccggtcaggcgtttttcgatccgg	Protospacer
**.***********.********.* *.

45. spacer 1.5|226069|31|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP045336 (Labrenzia sp. THAF191a plasmid pTHAF191a_c, complete sequence) position: , mismatch: 8, identity: 0.742

tgatgccccggtcaagcgttttttgtttgct	CRISPR spacer
tggtgccccggtcaggcgtttttcgatccgg	Protospacer
**.***********.********.* *.

46. spacer 1.7|226202|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to MT133560 (Pseudomonas phage fnug, complete genome) position: , mismatch: 8, identity: 0.733

aactttgacgtacttcaacaatattttact	CRISPR spacer
ttggttgacgtacttcaacactaatttcat	Protospacer
    **************** ** ***  *

47. spacer 1.7|226202|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP022558 (Geobacillus subterraneus strain E55-1 plasmid pGspE55-1, complete sequence) position: , mismatch: 8, identity: 0.733

aactttgacgtacttcaacaatattttact	CRISPR spacer
ctgtttgacgtacttcaacaaagtttggcg	Protospacer
   ****************** .*** .*

48. spacer 1.7|226202|30|NZ_LS483304|PILER-CR,CRISPRCasFinder,CRT matches to NC_042081 (Pseudomonas phage SL2, complete genome) position: , mismatch: 8, identity: 0.733

aactttgacgtacttcaacaatattttact	CRISPR spacer
ttggttgacgtacttcaacattaatttcat	Protospacer
    **************** ** ***  *

49. spacer 2.1|1141763|60|NZ_LS483304|CRISPRCasFinder matches to NC_020451 (Vibrio coralliilyticus strain ATCC BAA-450 plasmid, complete sequence) position: , mismatch: 8, identity: 0.867

-ccatatcgctaaatgcgggtgtagtttaatggcaaaacctcagccttccaagctgatgt	CRISPR spacer
gccataac-taaaatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatga	Protospacer
 ***** * . ******************.***.*************************

50. spacer 2.1|1141763|60|NZ_LS483304|CRISPRCasFinder matches to NZ_CP024037 (Bacillus aryabhattai strain K13 plasmid unnamed2) position: , mismatch: 10, identity: 0.833

ccatatcgctaaatgcgggtgtagtttaatggcaaaacctcagccttccaagctgatgtt	CRISPR spacer
ccactttaaaatatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgtc	Protospacer
***. *..  * ****************.***.**************************.

51. spacer 2.1|1141763|60|NZ_LS483304|CRISPRCasFinder matches to NZ_CP026740 (Bacillus megaterium strain YC4-R4 plasmid unnamed4) position: , mismatch: 10, identity: 0.833

ccatatcgctaaatgcgggtgtagtttaatggcaaaacctcagccttccaagctgatgtt	CRISPR spacer
ccactttaaaatatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgtc	Protospacer
***. *..  * ****************.***.**************************.

52. spacer 2.1|1141763|60|NZ_LS483304|CRISPRCasFinder matches to NZ_CP010587 (Bacillus megaterium Q3 plasmid p1, complete sequence) position: , mismatch: 10, identity: 0.833

ccatatcgctaaatgcgggtgtagtttaatggcaaaacctcagccttccaagctgatgtt	CRISPR spacer
ccactttaaaatatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgtc	Protospacer
***. *..  * ****************.***.**************************.

53. spacer 2.1|1141763|60|NZ_LS483304|CRISPRCasFinder matches to NZ_CP023319 (Bacillus megaterium strain A plasmid p2, complete sequence) position: , mismatch: 10, identity: 0.833

ccatatcgctaaatgcgggtgtagtttaatggcaaaacctcagccttccaagctgatgtt	CRISPR spacer
ccactttaaaatatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgtc	Protospacer
***. *..  * ****************.***.**************************.

54. spacer 2.1|1141763|60|NZ_LS483304|CRISPRCasFinder matches to NZ_CP015439 (Anoxybacillus amylolyticus strain DSM 15939 plasmid pDSM15939_1, complete sequence) position: , mismatch: 10, identity: 0.833

-ccatatcgctaaatgcgggtgtagtttaatggcaaaacctcagccttccaagctgatgt	CRISPR spacer
gtcgtat-ataatatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgt	Protospacer
 .*.*** .. * ****************.***.**************************

55. spacer 2.1|1141763|60|NZ_LS483304|CRISPRCasFinder matches to NC_017139 (Bacillus megaterium WSH-002 plasmid WSH-002_p1, complete sequence) position: , mismatch: 10, identity: 0.833

ccatatcgctaaatgcgggtgtagtttaatggcaaaacctcagccttccaagctgatgtt	CRISPR spacer
ccactttaaaatatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgtc	Protospacer
***. *..  * ****************.***.**************************.

56. spacer 2.1|1141763|60|NZ_LS483304|CRISPRCasFinder matches to NC_004604 (Bacillus megaterium QM B1551 plasmid pBM400, complete sequence) position: , mismatch: 11, identity: 0.817

ccatatcgctaaatgcgggtgtagtttaatggcaaaacctcagccttccaagctgatgtt	CRISPR spacer
ttttaagaaaacatgcgggtgtagtttaatggtaaaacctcagccttccaagctgatgtc	Protospacer
.. **  .  * ********************.**************************.

57. spacer 2.1|1141763|60|NZ_LS483304|CRISPRCasFinder matches to NZ_CP015440 (Anoxybacillus amylolyticus strain DSM 15939 plasmid pDSM15939_2, complete sequence) position: , mismatch: 11, identity: 0.817

ccatatcgctaaatgcgggtgtagtttaatggcaaaacctcagccttccaagctgatgtt	CRISPR spacer
gtatatattattatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgtc	Protospacer
 .****  .   ****************.***.**************************.

58. spacer 2.1|1141763|60|NZ_LS483304|CRISPRCasFinder matches to NZ_CP033045 (Bacillus foraminis strain Bac44 plasmid unnamed, complete sequence) position: , mismatch: 11, identity: 0.817

ccatatcgctaa--atgcgggtgtagtttaatggcaaaacctcagccttccaagctgatg	CRISPR spacer
--aaacttttaaccatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatg	Protospacer
  * *.. .***  ****************.***.*************************

59. spacer 2.1|1141763|60|NZ_LS483304|CRISPRCasFinder matches to NZ_CP041068 (Bacillus megaterium strain KNU-01 plasmid pKNU_01_4, complete sequence) position: , mismatch: 13, identity: 0.783

ccatatcgctaa----atgcgggtgtagtttaatggcaaaacctcagccttccaagctga	CRISPR spacer
----atttttaaaaataagcgggtgtagtttaatggtaaaacctcagccttccaagctga	Protospacer
    **. .***    * ******************.***********************

60. spacer 2.1|1141763|60|NZ_LS483304|CRISPRCasFinder matches to NZ_CP032535 (Bacillus megaterium NCT-2 plasmid pNCT2_7, complete sequence) position: , mismatch: 13, identity: 0.783

ccatatcgctaa----atgcgggtgtagtttaatggcaaaacctcagccttccaagctga	CRISPR spacer
----atttttaaaaataagcgggtgtagtttaatggtaaaacctcagccttccaagctga	Protospacer
    **. .***    * ******************.***********************

61. spacer 2.1|1141763|60|NZ_LS483304|CRISPRCasFinder matches to CP041516 (Bacillus aryabhattai strain KNU10 plasmid unnamed, complete sequence) position: , mismatch: 13, identity: 0.783

ccatatcgctaa----atgcgggtgtagtttaatggcaaaacctcagccttccaagctga	CRISPR spacer
----atttttaaaaataagcgggtgtagtttaatggtaaaacctcagccttccaagctga	Protospacer
    **. .***    * ******************.***********************

62. spacer 2.1|1141763|60|NZ_LS483304|CRISPRCasFinder matches to CP031730 (Stenotrophomonas rhizophila strain GA1 plasmid unnamed1, complete sequence) position: , mismatch: 15, identity: 0.75

ccatatcgcta-----aatgcgggtgtagtttaatggcaaaacctcagccttccaagctg	CRISPR spacer
-----tttttaaaaataaagcgggtgtagtttaatggtaaaacctcagccttccaagctg	Protospacer
     *. .**     ** ******************.**********************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

998248 : 1079555

Staphylococcus_phage(91.38%)

integrase,terminase,tail,holin

attL 1044466:1044486|attR 1062929:1062949

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_158484636.1\|998248_998425_+	hypothetical protein	A0A0N9SK66	Staphylococcus_phage	6.5e-06	37.9
WP_039644885.1\|998706_998937_+	hypothetical protein	NA	NA	NA	NA
WP_039644889.1\|999171_1000458_+	dicarboxylate/amino acid:cation symporter	NA	NA	NA	NA
WP_039644891.1\|1000502_1000922_-	hypothetical protein	A0A1Q1PVU5	Staphylococcus_phage	2.3e-17	37.7
WP_039644892.1\|1000924_1001434_-	hypothetical protein	A0A1Q1PVV5	Staphylococcus_phage	1.3e-38	50.0
WP_039644894.1\|1001655_1003179_-	N-acetylmuramoyl-L-alanine amidase	A0A0N9SGX6	Staphylococcus_phage	1.1e-104	42.5
WP_039644896.1\|1003234_1003630_-	hypothetical protein	A0A0H4IPB8	Staphylococcus_phage	9.5e-37	52.3
WP_052257807.1\|1003634_1006085_-	hypothetical protein	A0A0H3U4S3	Staphylococcus_phage	2.7e-20	40.1
WP_039644898.1\|1006109_1006430_-\|holin	phage holin	A0A1D6Z272	Staphylococcus_phage	5.7e-08	39.3
WP_039644900.1\|1006607_1007009_-	hypothetical protein	NA	NA	NA	NA
WP_039644902.1\|1007066_1009802_-\|tail	tail fiber domain-containing protein	A0A0N9SHX2	Staphylococcus_phage	7.5e-274	58.5
WP_158484638.1\|1009842_1010019_-	hypothetical protein	NA	NA	NA	NA
WP_039644909.1\|1010034_1010385_-	hypothetical protein	A0A0N9SK58	Staphylococcus_phage	1.8e-15	46.5
WP_052257808.1\|1010398_1017397_-	hypothetical protein	A0A0N9RTX0	Staphylococcus_phage	0.0e+00	38.5
WP_039644918.1\|1017447_1019526_-	hypothetical protein	A0A0N9SGW2	Staphylococcus_phage	8.1e-220	55.7
WP_039644928.1\|1019546_1028093_-\|tail	phage tail tape measure protein	A0A0N9S894	Staphylococcus_phage	0.0e+00	49.0
WP_039647563.1\|1028189_1029188_-\|integrase	site-specific integrase	A0A0N9SIX3	Staphylococcus_phage	5.0e-151	75.6
WP_052257809.1\|1029229_1029709_-	hypothetical protein	A0A0N9RRK6	Staphylococcus_phage	4.1e-26	39.6
WP_039644934.1\|1029721_1030264_-	hypothetical protein	A0A0N9SK55	Staphylococcus_phage	4.3e-56	59.8
WP_052257810.1\|1030332_1030737_-	Ig-like domain-containing protein	NA	NA	NA	NA
WP_052257811.1\|1030745_1031477_-	hypothetical protein	A0A0N7GFG4	Staphylococcus_phage	2.9e-63	54.0
WP_039644935.1\|1031511_1032321_-	hypothetical protein	A0A0N9RZR7	Staphylococcus_phage	3.4e-49	38.8
WP_039644936.1\|1032325_1032847_-	hypothetical protein	A0A0N9ST98	Staphylococcus_phage	1.3e-65	70.2
WP_039644937.1\|1032830_1033505_-	hypothetical protein	A0A0N9SHW2	Staphylococcus_phage	6.3e-81	67.7
WP_039644938.1\|1033506_1033923_-	hypothetical protein	A0A0N9RTW0	Staphylococcus_phage	2.4e-43	70.7
WP_039644942.1\|1033944_1034508_-	hypothetical protein	A0A0N9SGV3	Staphylococcus_phage	2.4e-49	62.8
WP_039644943.1\|1034589_1035591_-	hypothetical protein	A0A0N9S885	Staphylococcus_phage	6.4e-90	80.0
WP_039644944.1\|1035617_1036049_-	hypothetical protein	A0A0N9SIW4	Staphylococcus_phage	1.3e-42	65.8
WP_039644945.1\|1036077_1037583_-	hypothetical protein	A0A0N9RRJ7	Staphylococcus_phage	1.9e-93	42.7
WP_039644946.1\|1037575_1039126_-	hypothetical protein	A0A0N9SK48	Staphylococcus_phage	1.4e-208	69.0
WP_039644948.1\|1039145_1040951_-\|terminase	terminase	A0A0N9RZP6	Staphylococcus_phage	3.9e-162	78.2
WP_039644950.1\|1040950_1041841_-	hypothetical protein	A0A0N9SHV5	Staphylococcus_phage	6.8e-91	56.9
WP_158484640.1\|1042631_1043834_-	hypothetical protein	A0A0N9SK37	Staphylococcus_phage	7.5e-69	38.3
WP_039644953.1\|1043840_1044026_-	YonK family protein	A0A0N7GFG2	Staphylococcus_phage	3.2e-11	59.6
WP_039644955.1\|1044042_1044375_-	HU family DNA-binding protein	NA	NA	NA	NA
1044466:1044486	attL	NA	NA	NA	NA
WP_039644957.1\|1044576_1046058_-	hypothetical protein	A0A0N9SGU3	Staphylococcus_phage	5.0e-107	43.6
WP_039644959.1\|1046172_1048452_+	AAA family ATPase	A0A0N9S864	Staphylococcus_phage	6.1e-253	58.2
WP_039644962.1\|1048473_1049367_+	hypothetical protein	A0A0N9SIV7	Staphylococcus_phage	9.6e-37	34.9
WP_039644964.1\|1050045_1050390_+	hypothetical protein	NA	NA	NA	NA
WP_052257812.1\|1050701_1051265_+	thioredoxin domain-containing protein	NA	NA	NA	NA
WP_158484642.1\|1051538_1051712_-	hypothetical protein	NA	NA	NA	NA
WP_039644966.1\|1051733_1052276_-	hypothetical protein	NA	NA	NA	NA
WP_158484644.1\|1054612_1054753_+	hypothetical protein	NA	NA	NA	NA
WP_082021531.1\|1054941_1055142_+	hypothetical protein	A0A2H4PQT0	Staphylococcus_phage	1.3e-13	61.0
WP_158484646.1\|1055260_1055419_+	hypothetical protein	NA	NA	NA	NA
WP_039644968.1\|1055599_1055935_+	hypothetical protein	A0A0N9RTT7	Staphylococcus_phage	4.7e-21	43.9
WP_039644971.1\|1055989_1056349_+	hypothetical protein	NA	NA	NA	NA
WP_039644973.1\|1056364_1056628_+	hypothetical protein	NA	NA	NA	NA
WP_039644974.1\|1056917_1057172_+	hypothetical protein	NA	NA	NA	NA
WP_052257813.1\|1057364_1057964_+	antirestriction protein ArdA	A0A0N9SK30	Staphylococcus_phage	2.5e-20	33.5
WP_039644976.1\|1058017_1058587_+	hypothetical protein	NA	NA	NA	NA
WP_052257814.1\|1059267_1060308_+\|integrase	site-specific integrase	A0A0N9SK33	Staphylococcus_phage	4.6e-83	50.9
WP_039644978.1\|1060602_1061886_+	hypothetical protein	A0A0N9RZM2	Staphylococcus_phage	3.0e-124	52.3
WP_039644980.1\|1061895_1062915_+	hypothetical protein	A0A0N9ST56	Staphylococcus_phage	1.1e-63	40.3
WP_039644983.1\|1063046_1063289_+	hypothetical protein	NA	NA	NA	NA
1062929:1062949	attR	NA	NA	NA	NA
WP_039644984.1\|1063305_1063803_+	hypothetical protein	NA	NA	NA	NA
WP_039644985.1\|1063814_1064465_+	hypothetical protein	NA	NA	NA	NA
WP_039644986.1\|1064506_1065457_+	hypothetical protein	A0A0N7GFF9	Staphylococcus_phage	6.1e-98	60.3
WP_039644989.1\|1065559_1066528_+	ATP-binding protein	A0A0N9SGS5	Staphylococcus_phage	1.6e-141	75.2
WP_039644991.1\|1066712_1067234_+	hypothetical protein	A0A0N9S850	Staphylococcus_phage	2.3e-43	52.6
WP_052257815.1\|1067251_1068817_+	helicase DnaB	A0A0N9SIU7	Staphylococcus_phage	2.3e-219	72.6
WP_039644993.1\|1068832_1069945_+	hypothetical protein	A0A0N9RRG7	Staphylococcus_phage	6.0e-137	62.6
WP_111725056.1\|1070061_1071699_+	single-stranded DNA-binding protein	A0A0N9SK20	Staphylococcus_phage	5.4e-187	58.9
WP_052257816.1\|1072096_1072519_+	hypothetical protein	A0A0N9RRH5	Staphylococcus_phage	1.3e-23	46.6
WP_039644997.1\|1072536_1072941_+	hypothetical protein	I7DJR5	Staphylococcus_virus	5.5e-08	32.9
WP_039644998.1\|1072930_1073329_+	hypothetical protein	A0A1J0MFF1	Staphylococcus_phage	1.5e-29	52.3
WP_039644999.1\|1073325_1073682_+	hypothetical protein	Q4Z921	Staphylococcus_phage	6.6e-21	47.9
WP_086375155.1\|1073683_1073887_+	hypothetical protein	Q4ZC08	Staphylococcus_virus	7.5e-14	61.3
WP_039645001.1\|1073876_1074104_+	hypothetical protein	NA	NA	NA	NA
WP_039645002.1\|1074096_1074324_+	hypothetical protein	A1BUA9	Staphylococcus_virus	5.5e-05	34.6
WP_039645003.1\|1074324_1074612_+	hypothetical protein	A0A2I6PCT3	Staphylococcus_phage	9.2e-42	91.6
WP_167706482.1\|1074612_1074786_+	hypothetical protein	A0A2H4PQJ2	Staphylococcus_phage	4.9e-22	93.0
WP_039645005.1\|1074786_1074984_+	hypothetical protein	NA	NA	NA	NA
WP_039645006.1\|1074997_1075177_+	hypothetical protein	Q4ZD38	Staphylococcus_phage	2.8e-20	83.1
WP_039645007.1\|1075177_1075663_+	hypothetical protein	A0A1J0MFQ4	Staphylococcus_phage	1.9e-63	79.0
WP_167706483.1\|1075659_1075824_+	hypothetical protein	NA	NA	NA	NA
WP_039645008.1\|1075825_1076044_+	hypothetical protein	V5XV41	Staphylococcus_phage	2.1e-17	56.8
WP_039645010.1\|1076057_1076543_+	hypothetical protein	A0A2H4J513	uncultured_Caudovirales_phage	2.7e-25	42.5
WP_039645012.1\|1077764_1078076_-	hypothetical protein	A0A2H4JG55	uncultured_Caudovirales_phage	2.0e-13	42.7
WP_052257817.1\|1078733_1079555_-	trypsin-like peptidase domain-containing protein	A0A0E3T8P7	Staphylococcus_phage	2.5e-39	35.6

DBSCAN-SWA_2

1087999 : 1116457

Staphylococcus_phage(77.27%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_039645027.1\|1087999_1089103_+	hypothetical protein	Q4ZCZ1	Staphylococcus_virus	1.9e-74	40.7
WP_039647590.1\|1089530_1089905_+	hypothetical protein	NA	NA	NA	NA
WP_039645029.1\|1090368_1090854_-	hypothetical protein	NA	NA	NA	NA
WP_111725041.1\|1091197_1091959_+	metallophosphoesterase	A0A0N9SKA2	Staphylococcus_phage	2.2e-58	48.2
WP_039645030.1\|1091982_1095930_+	DNA polymerase III subunit alpha	A0A0N7GFH1	Staphylococcus_phage	0.0e+00	71.5
WP_039645032.1\|1096003_1096384_+	hypothetical protein	A0A0N9STI1	Staphylococcus_phage	2.8e-22	43.2
WP_039645034.1\|1096471_1096804_+	hypothetical protein	NA	NA	NA	NA
WP_039647594.1\|1096787_1098077_+	DNA ligase	A0A0N9SK95	Staphylococcus_phage	4.5e-144	59.5
WP_039645037.1\|1098167_1098653_+	hypothetical protein	NA	NA	NA	NA
WP_052257819.1\|1098701_1099118_+	thermonuclease family protein	A0A1W6JQ32	Staphylococcus_phage	3.4e-37	63.5
WP_162474603.1\|1099092_1099245_+	hypothetical protein	A0A0N9SH07	Staphylococcus_phage	6.4e-10	70.2
WP_039645039.1\|1099254_1099500_+	hypothetical protein	NA	NA	NA	NA
WP_039645041.1\|1099515_1099812_+	hypothetical protein	NA	NA	NA	NA
WP_158484648.1\|1099828_1100128_+	hypothetical protein	NA	NA	NA	NA
WP_039645045.1\|1100169_1100433_+	hypothetical protein	NA	NA	NA	NA
WP_039645047.1\|1100482_1101247_+	hypothetical protein	NA	NA	NA	NA
WP_039645050.1\|1101312_1101921_+	nucleoside 2-deoxyribosyltransferase	A0A0N9RZV9	Staphylococcus_phage	1.3e-77	69.7
WP_111725057.1\|1101954_1102140_-	DNA cytosine methyltransferase	Q77YW9	Bacillus_phage	3.6e-07	60.5
WP_158484650.1\|1102216_1103077_+	DNA (cytosine-5-)-methyltransferase	A0A219UR24	Bacillus_phage	1.7e-30	32.8
WP_039645056.1\|1103110_1103392_+	hypothetical protein	NA	NA	NA	NA
WP_039645058.1\|1103415_1103727_+	hypothetical protein	NA	NA	NA	NA
WP_039645060.1\|1103726_1104497_+	prohibitin family protein	W5RV94	Staphylococcus_phage	4.5e-67	62.3
WP_039645062.1\|1104496_1105102_+	hypothetical protein	W5R8R7	Staphylococcus_phage	1.6e-14	33.2
WP_039645064.1\|1105188_1105698_+	siphovirus Gp157 family protein	A0A0N9SIY9	Staphylococcus_phage	1.4e-37	49.1
WP_039645066.1\|1105709_1106408_+	hypothetical protein	A0A0N9RRN5	Staphylococcus_phage	1.7e-52	45.3
WP_167706484.1\|1106452_1106614_+	hypothetical protein	NA	NA	NA	NA
WP_052257820.1\|1106594_1106999_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A0N9RZU5	Staphylococcus_phage	3.2e-24	49.6
WP_039645067.1\|1107010_1110256_+	hypothetical protein	A0A1P8CX40	Bacillus_phage	0.0e+00	56.7
WP_086375159.1\|1110252_1111269_+	class 1b ribonucleoside-diphosphate reductase subunit beta	R4JMU8	Bacillus_phage	5.0e-98	56.6
WP_039645071.1\|1111298_1111943_+	AAA family ATPase	A0A0N9RTZ3	Staphylococcus_phage	2.8e-54	51.2
WP_039645074.1\|1111945_1112188_+	thioredoxin family protein	A0A0N9SGY3	Staphylococcus_phage	7.8e-26	68.4
WP_039645076.1\|1112205_1112439_+	hypothetical protein	NA	NA	NA	NA
WP_052257821.1\|1112452_1113166_+	NTP pyrophosphohydrolase	A0A0N9SIY2	Staphylococcus_phage	3.2e-83	63.8
WP_039645078.1\|1113171_1113519_+	hypothetical protein	NA	NA	NA	NA
WP_039645079.1\|1113499_1114099_+	RusA family crossover junction endodeoxyribonuclease	A0A0N7GFG7	Staphylococcus_phage	5.6e-81	77.1
WP_039645081.1\|1114341_1114914_+	hypothetical protein	NA	NA	NA	NA
WP_052257822.1\|1114906_1116457_+	recombinase family protein	A0A0N9RZT8	Staphylococcus_phage	7.6e-90	38.8

DBSCAN-SWA_3

1152237 : 1173652

Staphylococcus_phage(89.47%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_039645146.1\|1152237_1153647_+	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	2.4e-135	52.1
WP_039645148.1\|1153643_1154633_+	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	5.2e-84	47.6
WP_039645150.1\|1154629_1154860_-	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	6.5e-30	75.7
WP_039645152.1\|1154922_1155393_+	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	6.4e-40	52.2
WP_039647610.1\|1155397_1156156_+	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	4.3e-86	61.6
WP_039645154.1\|1156183_1157764_-	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	2.8e-241	75.4
WP_039645157.1\|1158193_1159393_+	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	2.1e-180	79.6
WP_039645159.1\|1159481_1160390_+	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	5.6e-93	69.4
WP_039645161.1\|1160570_1161407_+	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	1.5e-108	67.9
WP_039645163.1\|1161788_1162154_-	CrcB family protein	NA	NA	NA	NA
WP_039645165.1\|1162150_1162516_-	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	4.8e-27	52.9
WP_039645167.1\|1162536_1162839_-	hypothetical protein	NA	NA	NA	NA
WP_039645169.1\|1162993_1163704_+	transaldolase	M1PR54	Cyanophage	1.7e-20	37.0
WP_039645170.1\|1163797_1164247_+	hypothetical protein	NA	NA	NA	NA
WP_052257826.1\|1164229_1164664_-	hypothetical protein	NA	NA	NA	NA
WP_039645172.1\|1164678_1165140_-	sigma-70 family RNA polymerase sigma factor	A0A2H4PQT5	Staphylococcus_phage	3.6e-19	41.0
WP_039645174.1\|1165338_1165563_+	hypothetical protein	NA	NA	NA	NA
WP_039645176.1\|1165725_1166592_+	glucosaminidase domain-containing protein	Q4ZE13	Staphylococcus_virus	1.4e-40	39.7
WP_039645178.1\|1166930_1168601_+	FAD/NAD(P)-binding protein	A0A2H4PQX2	Staphylococcus_phage	6.2e-13	57.1
WP_039645180.1\|1168986_1170033_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	5.7e-105	51.7
WP_039645182.1\|1170037_1170667_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	3.8e-56	55.7
WP_039645184.1\|1170680_1171862_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	3.8e-150	65.4
WP_039645186.1\|1171873_1172332_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	1.6e-51	64.5
WP_052257827.1\|1172611_1173652_-	proline dehydrogenase family protein	A0A2H4PQT6	Staphylococcus_phage	5.1e-122	67.0

DBSCAN-SWA_4

1177240 : 1185391

Staphylococcus_phage(100.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_039645196.1\|1177240_1177804_-	methyltransferase domain-containing protein	A0A2H4PQV0	Staphylococcus_phage	2.1e-53	55.1
WP_039645198.1\|1177800_1178760_-	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	1.2e-61	79.2
WP_039645200.1\|1178871_1180053_+	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	1.6e-132	62.8
WP_039645202.1\|1180400_1182812_+\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	80.9
WP_039645205.1\|1182834_1183146_+	rhodanese-like domain-containing protein	A0A2H4PQR9	Staphylococcus_phage	1.0e-33	68.9
WP_039645207.1\|1184128_1185391_-	NAD(P)/FAD-dependent oxidoreductase	A0A2H4PQX1	Staphylococcus_phage	1.7e-34	77.2

DBSCAN-SWA_5

1295615 : 1307043

uncultured_Mediterranean_phage(42.86%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_039645391.1\|1295615_1296611_+	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	28.2
WP_039645393.1\|1296624_1297650_+\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_039645396.1\|1297663_1298803_+\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	2.4e-88	45.5
WP_039645397.1\|1298818_1299082_+	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.0e-08	52.6
WP_039645399.1\|1299389_1301669_+	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	5.5e-28	31.5
WP_039645401.1\|1301762_1304045_+	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	3.5e-67	30.6
WP_039645403.1\|1304056_1304575_+	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	4.0e-27	48.8
WP_039645405.1\|1304853_1307043_+	bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase	A0A2I2L310	Orpheovirus	1.9e-09	35.5

DBSCAN-SWA_6

1438702 : 1448250

Bacillus_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_039645663.1\|1438702_1439590_+	site-specific tyrosine recombinase XerD	A0A0K2CP59	Brevibacillus_phage	2.1e-39	32.1
WP_052257833.1\|1439613_1440117_-	DUF309 domain-containing protein	NA	NA	NA	NA
WP_039645665.1\|1440214_1440949_+	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	9.4e-06	29.3
WP_039645667.1\|1440932_1441478_+	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	3.0e-09	45.3
WP_039645669.1\|1441474_1442215_+	rRNA pseudouridine synthase	NA	NA	NA	NA
WP_039645671.1\|1442343_1443069_+	response regulator transcription factor	W8CYM9	Bacillus_phage	3.0e-44	40.5
WP_039647639.1\|1443052_1444789_+	HAMP domain-containing protein	W8CYF6	Bacillus_phage	1.0e-29	30.1
WP_039645673.1\|1444920_1445469_+	ECF transporter S component	NA	NA	NA	NA
WP_037573797.1\|1445573_1445822_-	ferredoxin	A0A127AYY7	Bacillus_phage	3.4e-16	52.0
WP_039645676.1\|1445927_1446884_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_039645678.1\|1446873_1448250_+	ATP-dependent DNA helicase RecQ	A0A2P1EM61	Moumouvirus	4.6e-54	32.9

DBSCAN-SWA_7

1843016 : 1851444

Prochlorococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_039646358.1\|1843016_1843583_-	phosphoribosylglycinamide formyltransferase	E3SNR5	Prochlorococcus_phage	5.7e-27	38.4
WP_039646360.1\|1843585_1844614_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.1e-63	43.2
WP_039646362.1\|1844618_1846040_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.6e-49	33.2
WP_039646365.1\|1846018_1848208_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	6.9e-137	39.3
WP_039646367.1\|1848200_1848872_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_039647678.1\|1848871_1849141_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_039646369.1\|1849143_1849851_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	G8EYA2	Synechococcus_phage	8.1e-47	42.4
WP_082021550.1\|1849847_1851044_-	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_039646374.1\|1850961_1851444_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	1.2e-22	45.3

DBSCAN-SWA_8

2035105 : 2041892

Streptococcus_phage(28.57%)

integrase

attL 2036378:2036392|attR 2044187:2044201

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_037567914.1\|2035105_2035306_-	cold-shock protein	Q9AZD3	Lactococcus_phage	2.2e-18	64.6
WP_039646677.1\|2035717_2036302_+	hypothetical protein	NA	NA	NA	NA
2036378:2036392	attL	NA	NA	NA	NA
WP_158484666.1\|2036527_2036767_+\|integrase	tyrosine-type recombinase/integrase	Q4ZC42	Staphylococcus_virus	1.0e-33	88.6
WP_039646679.1\|2037158_2037740_+	ATP-dependent Clp endopeptidase proteolytic subunit ClpP	A0A223W000	Agrobacterium_phage	1.6e-53	56.3
WP_039646681.1\|2037778_2038723_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	1.3e-52	39.3
WP_039646682.1\|2038859_2039867_-	YvcK family protein	A1IMD5	Streptococcus_phage	5.4e-52	42.6
WP_039646684.1\|2039853_2040777_-	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	4.4e-08	32.8
WP_039646686.1\|2040947_2041892_-	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	1.4e-83	49.8
2044187:2044201	attR	NA	NA	NA	NA

DBSCAN-SWA_9

2075192 : 2084805

uncultured_Caudovirales_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_039646736.1\|2075192_2077298_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	85.9
WP_039646739.1\|2077269_2077659_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	1.5e-42	62.8
WP_039646741.1\|2078376_2079246_+	DMT family transporter	NA	NA	NA	NA
WP_039646743.1\|2079275_2079776_+	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	1.0e-51	70.8
WP_039646745.1\|2080067_2081579_+	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	9.8e-74	34.8
WP_039646747.1\|2081941_2082871_+	diacylglycerol kinase family lipid kinase	A0A1V0SBJ0	Catovirus	3.2e-11	24.4
WP_039647713.1\|2083157_2083688_-	5'-3'-deoxyribonucleotidase	NA	NA	NA	NA
WP_039646749.1\|2083755_2084805_-	histidinol-phosphate transaminase	A0A1X6WGT4	Pacmanvirus	7.4e-20	26.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_LS483304

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection