CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_LS483366	Streptococcus salivarius strain NCTC7366 chromosome 1	3 crisprs	DEDDh,csa3,RT,DinG,csn2,cas2,cas1,cas9,WYL,cas3	0	5	9	1

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_LS483366_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LS483366_1

216481-216574

Orphan

Consensus_repeat	Method
TGTTCTAAAATTCGAGTTGGCAATTAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_LS483366_1

>merge|NZ_LS483366|1|216481-216574|CRISPRCasFinder
TGTTCTAAAATTCGAGTTGGCAATTAAGGGCTGTTCCCACCCTAAATGTTATCTTAGTCATAAGATGTGTTCTAAAATTCGAGTTGGCGATTAA

>NZ_LS483366|1|1|216481-216574|CRISPRCasFinder
TGTTCTAAAATTCGAGTTGGCAATTAA	GGGCTGTTCCCACCCTAAATGTTATCTTAGTCATAAGATG
TGTTCTAAAATTCGAGTTGGCGATTAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LS483366.1\|WP_002883626.1\|207935_209555_+\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
NZ_LS483366.1\|WP_111686465.1\|217403_218171_-\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_LS483366.1\|WP_002886486.1\|225338_225794_+\|LytTR-family-transcriptional-regulator-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|335768
NZ_LS483366.1\|WP_037605467.1\|215914_216403_+\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|238813
NZ_LS483366.1\|WP_070849287.1\|222850_223264_+\|YjdF-family-protein	unknown	unknown	gnl\|CDD\|378596
NZ_LS483366.1\|WP_002883644.1\|215245_215785_+\|transcription-termination/antitermination-protein-NusG	unknown	unknown	gnl\|CDD\|180161
NZ_LS483366.1\|WP_002886487.1\|225803_226235_+\|DUF3021-family-protein	unknown	unknown	gnl\|CDD\|378668
NZ_LS483366.1\|WP_002886472.1\|214707_214860_+\|50S-ribosomal-protein-L33	unknown	unknown	gnl\|CDD\|234783
NZ_LS483366.1\|WP_061652316.1\|224477_225320_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224428
NZ_LS483366.1\|WP_070849284.1\|221476_222709_+\|acyl-CoA-thioesterase/BAAT-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|370148
NZ_LS483366.1\|WP_084871123.1\|210574_210880_-\|DUF2752-domain-containing-protein	unknown	unknown	gnl\|CDD\|378499
NZ_LS483366.1\|WP_096832810.1\|220964_221420_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_LS483366.1\|WP_013989998.1\|210879_211212_-\|TM2-domain-containing-protein	unknown	unknown	gnl\|CDD\|377473
NZ_LS483366.1\|WP_084871124.1\|218364_220866_+\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234743
NZ_LS483366.1\|WP_014633641.1\|212331_214659_+\|PBP1A-family-penicillin-binding-protein	unknown	unknown	gnl\|CDD\|273955
NZ_LS483366.1\|WP_014633640.1\|216601_217411_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|319818
NZ_LS483366.1\|WP_111686464.1\|209639_210485_-\|superinfection-immunity-protein	unknown	unknown	gnl\|CDD\|379585
NZ_LS483366.1\|WP_002883656.1\|214868_215045_+\|preprotein-translocase-subunit-SecE	unknown	unknown	gnl\|CDD\|236066
NZ_LS483366.1\|WP_111686466.1\|223611_224478_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_LS483366.1\|WP_014633642.1\|211396_212266_-\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638

Protein	Function_ID	Function_description	E-value
NZ_LS483366.1\|WP_002883626.1\|207935_209555_+\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NZ_LS483366.1\|WP_111686465.1\|217403_218171_-\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	1.14406e-68
NZ_LS483366.1\|WP_002886486.1\|225338_225794_+\|LytTR-family-transcriptional-regulator-DNA-binding-domain-containing-protein	gnl\|CDD\|335768	pfam04397, LytTR, LytTr DNA-binding domain. This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.	1.56186e-21
NZ_LS483366.1\|WP_037605467.1\|215914_216403_+\|phosphatase-PAP2-family-protein	gnl\|CDD\|238813	cd01610, PAP2_like, PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.	1.13884e-12
NZ_LS483366.1\|WP_070849287.1\|222850_223264_+\|YjdF-family-protein	gnl\|CDD\|378596	pfam11208, DUF2992, Protein of unknown function (DUF2992). This bacterial family of proteins has no known function. However, the cis-regulatory yjdF motif, just upstream from the gene encoding the proteins for this family, is a small non-coding RNA, Rfam:RF01764. The yjdF motif is found in many Firmicutes, including Bacillus subtilis. In most cases, it resides in potential 5' UTRs of homologs of the yjdF gene whose function is unknown. However, in Streptococcus thermophilus, a yjdF RNA motif is associated with an operon whose protein products synthesize nicotinamide adenine dinucleotide (NAD+). Also, the S. thermophilus yjdF RNA lacks typical yjdF motif consensus features downstream of and including the P4 stem. Thus, if yjdF RNAs are riboswitch aptamers, the S. thermophilus RNAs might sense a distinct compound that structurally resembles the ligand bound by other yjdF RNAs. On the ohter hand, perhaps these RNAs have an alternative solution forming a similar binding site, as is observed with some SAM riboswitches.	1.36177e-39
NZ_LS483366.1\|WP_002883644.1\|215245_215785_+\|transcription-termination/antitermination-protein-NusG	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	3.28618e-82
NZ_LS483366.1\|WP_002886487.1\|225803_226235_+\|DUF3021-family-protein	gnl\|CDD\|378668	pfam11457, DUF3021, Protein of unknown function (DUF3021). This is a bacterial family of uncharacterized proteins.	8.36896e-08
NZ_LS483366.1\|WP_002886472.1\|214707_214860_+\|50S-ribosomal-protein-L33	gnl\|CDD\|234783	PRK00504, rpmG, 50S ribosomal protein L33; Validated.	2.86471e-18
NZ_LS483366.1\|WP_061652316.1\|224477_225320_+\|ABC-transporter-permease	gnl\|CDD\|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	0.000352861
NZ_LS483366.1\|WP_070849284.1\|221476_222709_+\|acyl-CoA-thioesterase/BAAT-N-terminal-domain-containing-protein	gnl\|CDD\|370148	pfam08840, BAAT_C, BAAT / Acyl-CoA thioester hydrolase C terminal. This catalytic domain is found at the C terminal of acyl-CoA thioester hydrolases and bile acid-CoA:amino acid N-acetyltransferases (BAAT).	6.04268e-26
NZ_LS483366.1\|WP_084871123.1\|210574_210880_-\|DUF2752-domain-containing-protein	gnl\|CDD\|378499	pfam10825, DUF2752, Protein of unknown function (DUF2752). This family is conserved in bacteria. Many members are annotated as being putative membrane proteins.	1.20743e-06
NZ_LS483366.1\|WP_096832810.1\|220964_221420_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.11513e-12
NZ_LS483366.1\|WP_013989998.1\|210879_211212_-\|TM2-domain-containing-protein	gnl\|CDD\|377473	pfam05154, TM2, TM2 domain. This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.	7.80642e-12
NZ_LS483366.1\|WP_084871124.1\|218364_220866_+\|leucine--tRNA-ligase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0
NZ_LS483366.1\|WP_014633641.1\|212331_214659_+\|PBP1A-family-penicillin-binding-protein	gnl\|CDD\|273955	TIGR02074, Includes:_Penicillin-insensitive_transglycosylase, penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NZ_LS483366.1\|WP_014633640.1\|216601_217411_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|319818	cd07516, HAD_Pase, phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily. Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.02348e-75
NZ_LS483366.1\|WP_111686464.1\|209639_210485_-\|superinfection-immunity-protein	gnl\|CDD\|379585	pfam14373, Imm_superinfect, Superinfection immunity protein. This family includes the E. coli bacteriophage T4 superinfection immunity (imm) protein. When E. coli is sequentially infected with two T-even type bacteriophage the DNA of the superinfecting phage is excluded from the host, into the periplasmic space. The immunity protein plays a role in this process.	1.45056e-07
NZ_LS483366.1\|WP_002883656.1\|214868_215045_+\|preprotein-translocase-subunit-SecE	gnl\|CDD\|236066	PRK07597, secE, preprotein translocase subunit SecE; Reviewed.	2.68913e-10
NZ_LS483366.1\|WP_111686466.1\|223611_224478_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	4.02834e-82
NZ_LS483366.1\|WP_014633642.1\|211396_212266_-\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	3.36425e-84

>NZ_LS483366.1|WP_037605467.1|215914_216403_+|phosphatase-PAP2-family-protein
MMNYKRFYDRISAPLRSYAKVLEGLNKLITRTFYLLFPIFLIWVWLRNGWFVLSTTVLIMGGGFFLLSLGRSLYNRPRPYQTWAIQPLIKKDSLGKSFPSRHVFSATVIAMLALTLNPWLGGTMLFLAGALALLRVLGGVHYPSDVLAGYVIGILIGLLLYL
>NZ_LS483366.1|WP_002883644.1|215245_215785_+|transcription-termination/antitermination-protein-NusG
MLDSFDKGWFVLQTYSGYENKVKENLLQRAQTYNMLENILRVEIPTQTVNVEKNGKVKEVEENRFPGYVLVEMVMTDEAWFVVRNTPNVTGFVGSHGNRSKPTPLLEEEIRQILISMGQTVDVFDTNIKVGDVVQIIDGAFMGQEGRVVEIENNKVKIMINMFGSETAAELELYQIAEL
>NZ_LS483366.1|WP_002883656.1|214868_215045_+|preprotein-translocase-subunit-SecE
MRQTGSIFKVLKDTTWPDRKQRWHDFISVLEYTAFFTVIIYAFDELLSRAMSALINFF
>NZ_LS483366.1|WP_002886472.1|214707_214860_+|50S-ribosomal-protein-L33
MAQKKASLACAECGSRNYSINVSSTPKPTRLEVNKFCKHCKKYTLHKETR
>NZ_LS483366.1|WP_014633641.1|212331_214659_+|PBP1A-family-penicillin-binding-protein
MTFFDNLKNKLFKEENSGKGKDSQPAEKSKNLQNKIKGLFAKKPDEVEQAVEDLDMSQESQETSRYQRSKQKKPIDTTKPLGKVQAFLSKFTLSPRNPIRRFWRRYHIGKILFILVAMLVLTVGSYLFYIAKTTNVSDLQDALKATTVIYDKEGNQAGSLSGQKGTYVELDAISDSLENAVIATEDRTFYENSGVNVKRFLLAIVSMGRFGGGSTITQQLAKNAFLTQEQTVTRKAKEFFLSLELTKKYSKQEILTMYLNNAYFGNGVWGVEDASQKYFGTSAANLTVDEAATLAGMLKGPEIYNPIDNIQNATNRRNTVLANMVDDKKLSQADADSAAGVDMASRLDDTYQGTGDDYKYPSYFDAVIEEATKTYGLSEDEIVKNGYKIYTEMDANSQANMQQTYENTYLFPTSESDGSTAQSASVALDPTTGAVRGLVGRVGGTSDTTFRNFNYATQGKRSPGSTIKPLVVYAPALASGWSINKDLPNKPIDYNGYTPTNYGDIETEDIPMYQALANSYNVPAVYLFNQIGIQKGISYGQKFGLNFDNVPEELGISLGGGVTASPLQMAQAYATFANGGEMNTAYFITKIENASGDIIATHSKKSKRVISQSVANQMTSMMLGTFSNGSAVNANYTGYTMAGKTGTVQAEFNKDLTSDQWVIGYTPDVVMTTWIGFDKTDESHYLTGASSGTASTIFSYIAADVLPNTPGTEFTVENAYAADGQTLDYTADPNDSRNSSNKSWTDKASDVVNDVKDQASSLWDKITDSFSGLFR
>NZ_LS483366.1|WP_014633642.1|211396_212266_-|RluA-family-pseudouridine-synthase
MTLHVEIINPYPATTVKDLLETKLLIPRKIRHFLRTKKHVLINGETINWQSPVEKGDKISLTFDTEDYPEKIIPMGNASLVEPLYEDQHLIVVNKPEGMKTHGNEPTEIALLNHVSAYCGQTCYVVHRLDMETSGAVLFAKNPFILPILNRLLEDKKIQRQYWALAEGKFQTKETVYKDKIGRDRHDRRKRVVDPRKGQVAYTTITRLKAFKGASLVNCQLKTGRTHQIRVHLAHHGHAILGDPLYSHRPASRLMLHAHTLSFTHPLTLDKITVKASSNSFEQGLRNHK
>NZ_LS483366.1|WP_013989998.1|210879_211212_-|TM2-domain-containing-protein
MNPVDQWITINAKYFPTEQVQYIRQRLEALPEQQLSMLYSISFQDPTMLLIISLLGGTLGIDRFLLGQIGLGVGKLLTCGGCGIWSIVDLFLIMDATRQSNAQKLFAVIG
>NZ_LS483366.1|WP_084871123.1|210574_210880_-|DUF2752-domain-containing-protein
MKNYFTRLWAYHQRFFRLYLLVLVTVYGVYLLHLPTPLSLILRPFGLKAWSTGLTRASVRLLHLDWQGAWDYNPLIYPLVVYVLTYFFLFPIFSDKKIIRK
>NZ_LS483366.1|WP_111686464.1|209639_210485_-|superinfection-immunity-protein
MKQQDWIDFFQAVNGRNPSIQEMAEAAQKGEFVRETPKQTVEVTETVSQKETVETKQDSEVVEPAESAPSTEVVETAEKNVDSYDVAEEPLVDSSINERQTFQTPNLGQESPTTNFQEQINPIQGTTNKASNPFAEQANASFQQTNSTLNEPWKNPEKKSQTNLIMIAIATIPVILWALGMILLGIASDDLSTGLITALLSVIINFPLVVLLILPALLNKTDKKWPIFILSFLLGWTFIGWIILLAVSINTNKEAERIRQQQMMMQMAGQQGSSDTFNPFQ
>NZ_LS483366.1|WP_002883626.1|207935_209555_+|chaperonin-GroEL
MAKDIKFSSDARAAMVRGVDTLADTVKVTLGPKGRNVVLEKAFGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVREGLKNVTAGANPIGIRRGIEAAVATAVEELKAIAQPVANKEAIAQVAAVSSRSEKVGEYISEAMERVGNDGVITIEESRGMETELEVVEGMQFDRGYLSQYMVTDNEKMVADLDNPFILVTDKKISNIQDVLPLLEEVLKTSRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAVLTGATVITEDLGLELKDATMAALGQASKVTVDKDSTVIVEGAGSTEAIANRVNLIKSQLETTTSEFDREKLQERLAKLSGGVAVVKVGAATETALKEMKLRIEDALNATRAAVEEGIVAGGGTALVNVIAKVAELDLEGDDATGRNIVLRALEEPVRQIAYNAGYEGSVIIDKLKNSPVGTGFNAANGEWVDMVEAGIIDPVKVTRSALQNAASVASLILTTEAVVANKPEPETPAAPAMDPGMMGY
>NZ_LS483366.1|WP_014633640.1|216601_217411_-|Cof-type-HAD-IIB-family-hydrolase
MSNIRLIISDIDGTILTSNHQVDEQLIELMPKLEKANIPFVLASARSPLGMQPIAHKLGLHDNPIACYNGALVLEGDRAIIQHPVDKSEIQELLSYLSTDYPSVSVNIYSGKDWITNELDKWSQLEGSITGESPIIKELQDTVSDSEPPIHKLLLIDEPEVIQDLHQKLLSMDFPQTAFYLSKDNYLEVTAKHVSKEHALLEVAKYYDLPLEEVMTIGDNFNDSPMLALAGLGIAMGNAPEGVKETANLVTASNDEHGVAQAIKKHVLN
>NZ_LS483366.1|WP_111686465.1|217403_218171_-|DeoR/GlpR-transcriptional-regulator
MYQEQRLEKILTLLEERGNLSVKEMVDALGVSKDTVRRDFDCLSQRNLAQRTHGGILPVKNTTVLGFQERQKGLTEDKKKMADLALSLVKEQSLLFFDVSTLMLEVSQKLTKSVTVYSHSLDNALVLSGKEGIDFHLLGGRFYSKNRFYYSLHEAQLLQHLQFDLAFFGAASLSQGVVSYEDEEDVAVKQLAMQAARTKILIAESDKYEKHSKYILGKIEDFDYWITDKKPDPDLVESLKDKVTILYDGKDSNYE
>NZ_LS483366.1|WP_084871124.1|218364_220866_+|leucine--tRNA-ligase
MSFYNHKEIEPKWQKYWADNHTFKTGTDASKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRFKRAQGYNVLHPMGWDAFGLPAEQYAMDTGNDPAEFTAENIANFKRQINALGFSYDWDREVNTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVEELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLNDLDDLDWPESIKDMQRNWIGKSTGANVTFKVKGTDKEFTVFTTRPDTLFGATFTVLAPEHDLVDAITTPEQAEAVADYKHQASLKSDLARTDLAKEKTGVWTGAYAINPVNGKEIPIWIADYVLASYGTGAVMAVPAHDERDWEFAKQFDLPIVEVLEGGNVEEAAYTEDGLHVNSDFLNGLNKEEAIAKIVAWLEEKGFGQEKITYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLVLPVTKDIRPSGTGESPLANLTDWLEVTREDGVKGRRETNTMPQWAGSSWYYLRYIDPHNTEKLADEDLLKQWLPVDIYVGGAEHAVLHLLYARFWHKFLYDLGVVPTKEPFQKLFNQGMILGTSYRDHRGALVATDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDVVEQYGADTLRVYEMFMGPLDASIAWSEEGLEGSRKFLDRVYRLITSKEIVAENNGALDKVYNETVKSVTEQIESMKFNTAIAQLMVFVNAANKEDKLYVGYAKGFIQLIAPFAPHLAEELWQTVAETGESISYIAWPTWDESKLVEDEIEIVVQIKGKVRAQLMVAKDLSREELQEVALANEKVKAEIDGKEIVKVIAVPNKLVNIVVK
>NZ_LS483366.1|WP_096832810.1|220964_221420_+|MarR-family-transcriptional-regulator
MNKKELHKFNNRFNSFVLAFEQLKKAQHRNSIDKSITINEVHLIDLIGRNQPVNLVKLSELLEVSRSAITQSVRRLTKKDLVSFEFAPDNEKNKYLILSKKGVDVFNIHKEQQEHIETAIFSVLKNYSDEDLQMVMKLMDDVEKVWQELPW
>NZ_LS483366.1|WP_070849284.1|221476_222709_+|acyl-CoA-thioesterase/BAAT-N-terminal-domain-containing-protein
MNIKIELISESDLADESFNIVIDGLKPREIYRVEMFLSDYYCINAPMLLAHDVLWKSTATFVSDKNGIIDISQTPSCSGSYEDIATMGLFFNAKPLTNRKKKLPNSLSKIPLLDHFFVEIKIIQGNTVVAKRTFTRYYMSSQISHQDIYEKHFQGRLFYDKKAIKAPALIIVSGSEGRIEKAQNIAQLLSSRGYICLAVAYFGLEGLPKHLERIPLECLVEAKDYLRQHPQVDSERIGIYGRSKGAELVLAEESIFNDVQCLVLNSPSDVVYEGIKGKWNSHTSSWTYLQKELPYQKFRLRDYLFSKLLKKSFPKDCSARIDIGQMHSPILLLGSTVDEIWDASSAIGDIVSYYKGHHITFKKYHETGHMLTVAHQPNHRYRKDWRLLMKESKDSWLATIHFFDRHLKKQ
>NZ_LS483366.1|WP_070849287.1|222850_223264_+|YjdF-family-protein
METISIGLTVYFEDGFWHGLFEQVYRESYQVCRVTFGQEPKDDEILEILQTQFTQLSFSPETTANQHVKIKNPKRLQRAVKKQVNQKVSSKSKELLQLQYEERKKISKHQSSVQKQLLKQEKFERKQQKRRDKNKGH
>NZ_LS483366.1|WP_111686466.1|223611_224478_+|ABC-transporter-ATP-binding-protein
MILQAKNISKRYGNHLAVDNIQLQFKRGTFNAILGPNGAGKSTTISMLIGLKQPTQGEIIYEPGTKIGVVFQTSVLDEMLTVRENLAIRARQYKGLKPNRVSSLIDRLGLSAFQKQKYGTLSGGQKRRVDIARALLSQPDILFLDEPTTGLDIQTRKSIWDLLYQLQREEGMTVVLTTHYLDEADEADQIYIVDHGKLIAQGSALDIKSQYAKNILKIRFKEIEQIESLKTSGMSVEQQSQLEYVFQPESEREAIDYLAQVRDRIAHFEFRPGTMDDAFIALTGREVR
>NZ_LS483366.1|WP_061652316.1|224477_225320_+|ABC-transporter-permease
MLALLKRNFLLYFRNRPGVFFSLLGALISFILYIIFLQKNLTDAWAQLPNSGPLLNNWLMSGTLAVTGITTSLAALTQLVKDREHQVDKDLYLSNQGKWRLPFSYLASAIIISFAMQVLMYVLMCSYFREVPKLYILPELLLIMMLSSLLSSLVNAILVYFFQSVDSLGKFATIVGTASGFLVGTYVPLGVLPDFAQLLMKCTPATYIAALYRQVLMKETLSETFKGQDNLLQEFQEKMGVQLKWQGLLTKENTYLIVLGGILLASILWIILVKRTSQKK
>NZ_LS483366.1|WP_002886486.1|225338_225794_+|LytTR-family-transcriptional-regulator-DNA-binding-domain-containing-protein
MKLRFEEKSDISAKDPCVVIQAERLSDQAREVMDYLEQFSVVNQVVIPIKTDDHLVMVKIDDIILAEIDKNVLTIYTVNNTYTMRETLTNFQHRINRRSFLQISRHAVMNIDHLESLSDSFSGNMMAKMTGGVKSSVSRKYVKSLMDYLGV
>NZ_LS483366.1|WP_002886487.1|225803_226235_+|DUF3021-family-protein
MKRLIAYFVSGVRTGSFFYLALLLLGQLFPQLIYPKVSVGNILALFMMSGLMGMLSWILEEIDCISYRLRIILHFLLTAIVLTVTCLISGWYEALTNPAIWIVFISVYSIIWLYLIWQMHMRTQRINQALLHRRSQKKKSNKL

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Crispr_ID: NZ_LS483366_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LS483366_2

1244840-1244911

Orphan

Consensus_repeat	Method
GGACCTAAAAAGGTCCACTGAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_LS483366_2

>merge|NZ_LS483366|2|1244840-1244911|CRISPRCasFinder
GGACCTAAAAAGGTCCACTGAACAGCCTCGCTTTTGGGTTTCTTGGCTCGGACCTAAAAAGGTCCACTGGAC

>NZ_LS483366|2|2|1244840-1244911|CRISPRCasFinder
GGACCTAAAAAGGTCCACTGAAC	AGCCTCGCTTTTGGGTTTCTTGGCTC
GGACCTAAAAAGGTCCACTGGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LS483366.1\|WP_014633210.1\|1231773_1233045_-\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|236486
NZ_LS483366.1\|WP_013990691.1\|1237028_1238180_-\|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)	unknown	unknown	gnl\|CDD\|223458
NZ_LS483366.1\|WP_013990698.1\|1247101_1248013_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl\|CDD\|234626
NZ_LS483366.1\|WP_013990696.1\|1244915_1246568_-\|DNA-polymerase-III-subunit-gamma/tau	unknown	unknown	gnl\|CDD\|235505
NZ_LS483366.1\|WP_013990687.1\|1233670_1234774_-\|endoglucanase	unknown	unknown	gnl\|CDD\|366548
NZ_LS483366.1\|WP_003092510.1\|1248088_1248265_+\|DUF3042-family-protein	unknown	unknown	gnl\|CDD\|371431
NZ_LS483366.1\|WP_013990695.1\|1243587_1244526_+\|bifunctional-biotin--[acetyl-CoA-carboxylase]-synthetase/biotin-operon-repressor	unknown	unknown	gnl\|CDD\|237010
NZ_LS483366.1\|WP_084871400.1\|1241062_1242049_+\|IS30-family-transposase	unknown	unknown	gnl\|CDD\|225382
NZ_LS483366.1\|WP_002883489.1\|1250962_1251310_-\|50S-ribosomal-protein-L19	unknown	unknown	gnl\|CDD\|235418
NZ_LS483366.1\|WP_013990699.1\|1248643_1248784_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LS483366.1\|WP_111686601.1\|1233112_1233349_-\|DUF1146-domain-containing-protein	unknown	unknown	gnl\|CDD\|131380
NZ_LS483366.1\|WP_002883500.1\|1244512_1244698_-\|DUF3272-family-protein	unknown	unknown	gnl\|CDD\|314526
NZ_LS483366.1\|WP_070655716.1\|1242114_1243308_-\|methionine-adenosyltransferase	unknown	unknown	gnl\|CDD\|235374
NZ_LS483366.1\|WP_045769136.1\|1236237_1237026_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LS483366.1\|WP_037600189.1\|1252660_1252945_-\|chorismate-mutase	unknown	unknown	gnl\|CDD\|168880
NZ_LS483366.1\|WP_014633211.1\|1234782_1236093_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133045
NZ_LS483366.1\|WP_013990697.1\|1246567_1247077_-\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|224867
NZ_LS483366.1\|WP_070575970.1\|1251437_1252664_-\|voltage-gated-chloride-channel-family-protein	unknown	unknown	gnl\|CDD\|239654
NZ_LS483366.1\|WP_014633218.1\|1249535_1250249_-\|minor-capsid-protein	unknown	unknown	gnl\|CDD\|309383
NZ_LS483366.1\|WP_013990700.1\|1249087_1249330_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_LS483366.1\|WP_014633210.1\|1231773_1233045_-\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	gnl\|CDD\|236486	PRK09369, PRK09369, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated.	0
NZ_LS483366.1\|WP_013990691.1\|1237028_1238180_-\|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)	gnl\|CDD\|223458	COG0381, WecB, UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane].	6.87982e-174
NZ_LS483366.1\|WP_013990698.1\|1247101_1248013_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl\|CDD\|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	1.89277e-134
NZ_LS483366.1\|WP_013990696.1\|1244915_1246568_-\|DNA-polymerase-III-subunit-gamma/tau	gnl\|CDD\|235505	PRK05563, PRK05563, DNA polymerase III subunits gamma and tau; Validated.	0
NZ_LS483366.1\|WP_013990687.1\|1233670_1234774_-\|endoglucanase	gnl\|CDD\|366548	pfam01270, Glyco_hydro_8, Glycosyl hydrolases family 8.	2.46372e-19
NZ_LS483366.1\|WP_003092510.1\|1248088_1248265_+\|DUF3042-family-protein	gnl\|CDD\|371431	pfam11240, DUF3042, Protein of unknown function (DUF3042). This family of proteins with unknown function appears to be restricted to Firmicutes.	4.05312e-16
NZ_LS483366.1\|WP_013990695.1\|1243587_1244526_+\|bifunctional-biotin--[acetyl-CoA-carboxylase]-synthetase/biotin-operon-repressor	gnl\|CDD\|237010	PRK11886, PRK11886, bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA.	2.02309e-131
NZ_LS483366.1\|WP_084871400.1\|1241062_1242049_+\|IS30-family-transposase	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	1.40967e-88
NZ_LS483366.1\|WP_002883489.1\|1250962_1251310_-\|50S-ribosomal-protein-L19	gnl\|CDD\|235418	PRK05338, rplS, 50S ribosomal protein L19; Provisional.	6.42285e-69
NZ_LS483366.1\|WP_111686601.1\|1233112_1233349_-\|DUF1146-domain-containing-protein	gnl\|CDD\|131380	TIGR02327, conserved_hypothetical_protein, conserved hypothetical integral membrane protein. Members of this protein family are small, typically about 80 residues in length, and are highly hydrophobic. The gene is found so far only in a subset of the Firmicutes in association with genes of the ATP synthase F1 complex or NADH-quinone oxidoreductase. This family includes ywzB from Bacillus subtilis; pfam06612 describes the same family as Protein of unknown function DUF1146.	1.45527e-06
NZ_LS483366.1\|WP_002883500.1\|1244512_1244698_-\|DUF3272-family-protein	gnl\|CDD\|314526	pfam11676, DUF3272, Protein of unknown function (DUF3272). This family of proteins with unknown function appears to be restricted to Streptococcus.	9.03935e-09
NZ_LS483366.1\|WP_070655716.1\|1242114_1243308_-\|methionine-adenosyltransferase	gnl\|CDD\|235374	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated.	0
NZ_LS483366.1\|WP_037600189.1\|1252660_1252945_-\|chorismate-mutase	gnl\|CDD\|168880	PRK07248, PRK07248, chorismate mutase.	1.19569e-39
NZ_LS483366.1\|WP_014633211.1\|1234782_1236093_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|133045	cd06423, CESA_like, CESA_like is the cellulose synthase superfamily. The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.	1.32005e-53
NZ_LS483366.1\|WP_013990697.1\|1246567_1247077_-\|GAF-domain-containing-protein	gnl\|CDD\|224867	COG1956, COG1956, GAF domain-containing protein [Signal transduction mechanisms].	1.04341e-72
NZ_LS483366.1\|WP_070575970.1\|1251437_1252664_-\|voltage-gated-chloride-channel-family-protein	gnl\|CDD\|239654	cd03682, ClC_sycA_like, ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation competitiveness, and N2 fixation on Phaseolus vulgaris plants, due to its reduced ability for acid resistance. This family is part of the ClC chloride channel superfamiy. These proteins catalyse the selective flow of Cl- ions across cell membranes and Cl-/H+ exchange transport. These proteins share two characteristics that are apparently inherent to the entire ClC chloride channel superfamily: a unique double-barreled architecture and voltage-dependent gating mechanism. The gating is conferred by the permeating anion itself, acting as the gating charge.	5.2016e-172
NZ_LS483366.1\|WP_014633218.1\|1249535_1250249_-\|minor-capsid-protein	gnl\|CDD\|309383	pfam04233, Phage_Mu_F, Phage Mu protein F like protein. Members of this family are found in double-stranded DNA bacteriophages, and in some bacteria. A member of this family is required for viral head morphogenesis in bacteriophage SPP1. This family is possibly a minor head protein. This family may be related to the family TT_ORF1 (pfam02956).	3.5537e-18

>NZ_LS483366.1|WP_002883500.1|1244512_1244698_-|DUF3272-family-protein
MIQQILFITLETIFETVCFNYSLQHGYYFFTAFFGYLLFRRLWTTYVVSRIARAADKSTKK
>NZ_LS483366.1|WP_013990695.1|1243587_1244526_+|bifunctional-biotin--[acetyl-CoA-carboxylase]-synthetase/biotin-operon-repressor
MKTYEHVYDILSKSPDFVTGESLAKSLGVSRTAIWKAIQTLQEQGIDITSVRKKGYYLEKGDILLPQDISKQLNIPVYFNPDSNSTQLDAKHGMEKNNPTPALYLASSQKAAKGRFERHFFASPQGGIYMSIHLKPNCHFEELPPYTMMAAAAIVKAIQRLTGINTEIKWVNDIYLNNKKMAGILTEAISSIESGRITDVIIGVGLNFSISDFPEELANKATSLFTSEKPSITRNQLISEIWRLFLTIPTSDLVKVYKEKSLVLDKQVTFEQAGKTYTGVAKEIGDKGQLLVLTDDGREKWLTAGEVSLTSW
>NZ_LS483366.1|WP_070655716.1|1242114_1243308_-|methionine-adenosyltransferase
MSERKLFTSESVSEGHPDKIADQISDAILDAILAEDPDAHVAAETAVYTGSVHVFGEVSTTAYVDINRVVRDTIAEIGYNNAEYGFAAESVGVHPSLIEQSPDIAQGVNEALEVRGTGDQDPLDLIGAGDQGLMFGFAIDETPEFMPLPVSLSHKLVKKLADLRKSGEISYLRPDAKSQVTVEYDENDQPVRVDTVVISTQHDPEATNDQIRQDVIEKVIKAVIPAEYLDDETKFFINPTGRFVIGGPQGDSGLTGRKIIVDTYGGYSRHGGGAFSGKDATKVDRSASYAARYIAKNIVAAGLAKKAEVQLAYAIGVANPVSVRVDTFGTATVAESKLEAAVRDLFDLRPAGIIQMLDLKRPIYRQTAAYGHMGRTDIDLPWEKLDKVDALKTAVEA
>NZ_LS483366.1|WP_084871400.1|1241062_1242049_+|IS30-family-transposase
MSYHHFTIDERESILIYRTQGLNFSQIAKLLHRHPSSISREWKRHTKSGAYSPNHAQESYHNAKSHCGRKRMLEIDHNLSNTIKHLFLDYQWSPEEIEGRLRLEYGKTVVSYQTIYRAIYRGHFEDNSLSHGARGVIRKLRHRGKTRHTKGHVENRGKISISHTIHGRPEEANNRTRIGDWEADTVAGKIGKACLVTLTDRYSRFLKIKKVAVKKSKLVIEAMVKMLEPLTKYTVTPDRGKEFTYHQKLSDQLNIEVYFPDPHAPWQRGTNENTNGLLREYFPKGSDLTLVDDQTIQLWENKLNNRPRKCFNWKTPYEVFYGESMHLI
>NZ_LS483366.1|WP_013990691.1|1237028_1238180_-|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)
MGKLNIMVVFGTRPEAIKMAPLILELKKHQETINTITVVTAQHRQMLDQVLDTFEIVPDYDLDIMGKNQSLQEITSKILSKFDPVVRKEKPDLVLVHGDTTTTFAAGLVAFYNKVSIGHVEAGLRTYDKYSPYPEEMNRQMTDSFSDLYFAPTQESKANLLSENHKKEAIYVTGNTAIDALKLTVKDNYYHEVLDKIDDRRKIILVTMHRRENQGEPMHRVFKTLRLMVDNHPEIEVVYPVHLSPSVQAVAKEVLGDHDRIHLIAPLDVFDFHNLASRSYFIMSDSGGVQEEAPSLGKPVLVLRDTTERPEGVKAGTLKLVGTDTKKVKEAMESLLTDEALYKEMSEAPNPYGDGKAAERIVQAIKVYFNLADSVSEFHEGGD
>NZ_LS483366.1|WP_045769136.1|1236237_1237026_-|hypothetical-protein
MKKDKKVWYWILFLIFFEALLFSYCYQFNPEYFMFESILLVLGIGAVCFLSELLITWMIILSFALSIFILVSGVVYISLQDTLVLIFSFPLLLGILSKIKSYFYKYISSVQIEERKARKSYQAVLKEIKLNENKFINALLIHYSHEEQFFELDPREYNHLITSIYLKISKQLNRFEQIFYVADGSFLILSKNDSRNLNDFYKDSLERQLKGITFDWGNNHQSIQFQTGFLEINKNNLKKFDDYSELISNLNRQLETDIIVEY
>NZ_LS483366.1|WP_014633211.1|1234782_1236093_-|glycosyltransferase-family-2-protein
MVSQFLMIFTLVSIWISLIWGVVILVSGVHFWLKHSDFKVDKKALPYYPKVTIVVPAHNEDVVIAQTAKAILNLNYPHDKVELLLFADNCSDSTYEECLSVQALPEYEGRNITIINRKGTGGKAGVLNDALKMAEGDYICIYDADAMPEKNALYFLVKEVLKDPERRVAAFGRNKTRNAKQNFLTRCINQEIVVTQRVHHVGMWHLFKIGRIPGTNFIIQTDFVKSIGGWRNGALTEDTDISFKIMQSGKLIALAYNSEAFQQEPETLKSYYMQRKRWAKGNYEVVLSNFKHLFGKGNWRVKLEVANYSCIFFWFNGAIVLSDLIFFANVLAIILHPFFPTIQIPFAFDASNIYIAQLMLFNWLLMIGLYLLQINVALASQFGQATSKQVWLAILSYFSYAQLFIIVSLDSLWSIIMDKVLHREGTTWVKTKRFAE
>NZ_LS483366.1|WP_013990687.1|1233670_1234774_-|endoglucanase
MKIKYFKYFWFIVTLGLFVFLMFSVRIKTKTDIRNRIYQQWERHFVVKDGNEAYIKTTNDKDKDIVLSESQSYGMLITVRAAQKGLASQQDFERLYKYYLSHRIEGSQLMSWEQIVQKSSKNVDEHNATDGDLYIAYALIEASKQWPSQKDEYQTQSKAILQDILKYNYNENTGILTVGNWANRDSKYYNLMRTSDALPKQFQSFYEVTKDKKWLSISDKMLSSLETISSQTETGLIPDFIWVDQSGVRNVKPHTISSQFDSTYSYNACRLPYNLTQSNDEKSQRVLSKLLDFFMTQKNIFSNYNLDGNFLDDHQAACFKAPIALAADKDSGYLKLVQQNKIVFMQNLPVNNYYDSAIITLVTMEFF
>NZ_LS483366.1|WP_111686601.1|1233112_1233349_-|DUF1146-domain-containing-protein
MTIINQFVTLASHLVFIGLSYHMLISLFDWAKIIKNPIENTGKLKLFLLFISIALGYLIISFILSVLAFGQNMASSIS
>NZ_LS483366.1|WP_014633210.1|1231773_1233045_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase
MDKIIVQGGNTRLSGEVVIEGAKNAVLPLLAATILASEGQTTLTNVPILSDVYTMNNVVRGLDVAVDFDEENNTVVVDASGEILDQAPYEYVSKMRASIVVLGPILARNGHAKVSMPGGCTIGSRPIDLHLKGLEAMGAKITQVGGDITATVENLKGATIYMDFPSVGATQNLMMAATLADGVTTIENAAREPEIVDLALLLNEMGADVKGAGTETLVIKGVKALHGTKHAVVQDRIEAGTFMVAAAMTSGDVLIKDAIWEHNRPLISKLLEMGVDVKEEEGGIRVKSDVSQLKPVTVKTLPHPGFPTDMQAQFTALMAVVNGESTMIETVFENRFQHLEEMRRMGLHSEILRDTAMIHGGLPLQGAQVMSTDLRASAALILTGMVAEGTTTVGKLTHLDRGYYQFHEKLAKLGANISRVSEA
>NZ_LS483366.1|WP_013990696.1|1244915_1246568_-|DNA-polymerase-III-subunit-gamma/tau
MYQALYRKYRSQTFGEMVGQKVISTTLRQAVESGKISHAYLFSGPRGTGKTSAAKIFAKAMNCPNQVDGEPCNHCDICRDITNGSLEDVIEIDAASNNGVDEIREIRDKSTYAPSRATYKVYIIDEVHMLSTGAFNALLKTLEEPTENVVFILATTELHKIPATILSRVQRFEFKSIKQGAIKEHLASILEKEGLTFDDEALTIIARRAEGGMRDALSILDQALSLSPDNHVSQAVAEEITGSIGLTALDSFVANVRNQETTQALSNLETLFDNGKSMSRFATDLLEYFRDLLIVKAGGENSHHSPLFEENLSLEQDRLFQLIDLVTSALPEIKTGTHPKIYAEMLTIKLSETHTQASQEIPGNLQEELDSLRREVEGLRKALKEGKAQGEVAPTRKAKPAYQYKVDREKILTIMRETMENPQKSRQCLDALKATWPEILDSISPQNRALLNGSEPVLANQENAILAFNAAFNAEQVMKRSDLNDMFGNIMSSAAGFSPNIMAVPKAEFEKLRTEFARSLKSKEELEKEDREEYIPQELDFLSDVVEIED
>NZ_LS483366.1|WP_013990697.1|1246567_1247077_-|GAF-domain-containing-protein
MVVMTNEEKKSAYELMLAQAKVLFANEDNAMANFSNASALLNTTLPNSVFTGFYLMDNVKNELILGPFQGNVSCVRIALGKGVCGQSAAENRTLIVEDVTKHANYIACDSAARSEIVVPMVKDGKLVGVLDLDSHQVGDYNDVDQDYLEAFIKILLEKTELTFGMFEVN
>NZ_LS483366.1|WP_013990698.1|1247101_1248013_-|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
MKTKLIVVAGPTAVGKTALGIELAKRFNGEIISGDSQQVYRQLNIGTAKATPEEQAAAVHHLIDVRDVDESYSAYDFVIEAEVAISDIVSRGKLPIIVGGTGLYLQSLLEGYHLGGQVDQEQVLAYRSELEQLSDQELFEKIDRLGIEIKEINRRRAIRALELHRFSENLENTETTYDPFLIGLDDKRSLIYDRINTRVDKMVEHGLLEEAMWLYENYPNAQSARGIGYKELFPYFAGNQSLDEALEKLKQNTRRFAKRQLTWFRNRMTVKFYQISSPEYPKNVVQDLELFLNEREGEKVGQS
>NZ_LS483366.1|WP_003092510.1|1248088_1248265_+|DUF3042-family-protein
MAKKHSFAKGLATGVLGTAATVAGAVFAVKKTIIEPEEKKLAFIEENRKKAARRRVSR
>NZ_LS483366.1|WP_013990699.1|1248643_1248784_-|hypothetical-protein
MPNGSLGSTVFGTTPEESDLQSGNTPEAEVEVVDQGFAITTTKTID
>NZ_LS483366.1|WP_013990700.1|1249087_1249330_-|hypothetical-protein
MAMSYSQNLKELKQLCEYLWDADFEVDGKTVSILPESENNIVVVYDGKEIIVKSFDELIELKLDGVTLPKLMENVEVRYA
>NZ_LS483366.1|WP_014633218.1|1249535_1250249_-|minor-capsid-protein
MSVGRQELLIQELELELLVLSEGERQLTNDYLMNGYKSEIVRGSLLDQTVPNKKTLERYMTTAVNANFEGAKWSERIWGRNAQLRQLVRTEVTRALIRGNNGLTIARRIRKHMDVLRTNAERLGITEHARVQTLAQKDIMKENGFEYFKLMPDSRACDYCKQVGRDTEKEPVPIDKIDSGLNAPPMPPYCHCAVAEVYLDKEKLHKINENGIVQVDEVINGTPHPVGEARKVIQHNA
>NZ_LS483366.1|WP_002883489.1|1250962_1251310_-|50S-ribosomal-protein-L19
MNPLIQSLTEGQLRTDIPSFRPGDTVRVHAKVVEGTRERIQIFEGVVISRKGQGISEMYTVRKISSGIGVERTFPIHTPRVEKIEVVRYGKVRRAKLYYLRALQGKAARIKEIRK
>NZ_LS483366.1|WP_070575970.1|1251437_1252664_-|voltage-gated-chloride-channel-family-protein
MKVKQLSDSQGLSYLHLVMLSLYAILLGVLVGLIDAVFGRVLIGLSEYRDQHIFYLVPALPLAGLLIVYLYQKLAGKAAQGMGLIFKVGHNEEDQVPLRLIPLVTVTTWLTHLFGGSAGREGVAVQLGATVSHAFSRYFKIPNASRIFLTMGMAAGFGGLFQTPIAATFFALEVLTLGQLSLPILVPTLIASFVASTTSHLLGLEKFSHFVSDSLTIDLETFVKLALLGLVFGVAGNLFAYLLSVAKKKVASLLPNPYYRVLLGSVVLTCLLLILWKGRYTGLGTNLIALSVGGGTIYPLDWLLKLLLTVFTLSLGFQGGEVTPLFAIGASLGAVLAPVLGLPIPLVAGLGYLSVFGSSTNTLLAPIFIGVEVFGPANALPYAIVMAFAYLINHKTSIYGQQKMLEMQ
>NZ_LS483366.1|WP_037600189.1|1252660_1252945_-|chorismate-mutase
MDLNEIRQQIDTVDNEIVALLEERMKLVTRVSAYKQRTGKAIYDPEREQALLDKVGASVLNSEYKEAIVASFADIMKHSRIYQASKLEKSRHLE

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Crispr_ID: NZ_LS483366_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LS483366_3

1452052-1452612

TypeII

Consensus_repeat	Method
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	CRISPRCasFinder
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	CRT
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	PILER-CR

8 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of NZ_LS483366_3

>merge|NZ_LS483366|3|1452052-1452612|CRISPRCasFinder,CRT,PILER-CR
ACTGTACAGTCACTTAAATCTTAAAGTACAAAAAAGGGGTTGTGCTTTCCGTCCAAAACTGCTCAGTTGTACAGTTACTTAAATCTTGAGAGTACAAAAACAGCGTGTTGATCCGTTAGCTTTAAAATCAAGTTGTACAGTTACTTAAATCTTGAGAGTACAAAAACACATCATCAATTCTGTATCAGCATTAATGCGTTGTACAGTTACTTAAATCTTGAGAGTACAAAAACCAACGGTGCTGTCTGTGAACTTGTTTTCTGTTGTACAGTTACTTAAATCTTGAGAGTACAAAAACAGACAATTAAGCTAAATTCAGCCCCGCCGTGTTGTACAGTTACTTAAATCTTGAGAGTACAAAAACAGTAGTGCACCCACCCAGGACGTTTCAGCGTTGTACAGTTACTTAAATCTTGAGAGTACAAAAACAGACGTTAGCGCGTATCAGCCTGGCGACTTGTTGTACAGTTACTTAAATCTTGAGAGTACAAAAACACCTCTTGATGTTGAAGGAAAGGTGAAAATGTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC

>NZ_LS483366|3|3|1452052-1452612|CRISPRCasFinder
ACTGTACAGTCACTTAAATCTTAAAGTACAAAAAAG	GGGTTGTGCTTTCCGTCCAAAACTGCTCA
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	AGCGTGTTGATCCGTTAGCTTTAAAATCAA
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	ACATCATCAATTCTGTATCAGCATTAATGC
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	CAACGGTGCTGTCTGTGAACTTGTTTTCT
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	AGACAATTAAGCTAAATTCAGCCCCGCCGT
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	AGTAGTGCACCCACCCAGGACGTTTCAGC
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	AGACGTTAGCGCGTATCAGCCTGGCGACTT
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	ACCTCTTGATGTTGAAGGAAAGGTGAAAAT
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC

>NZ_LS483366|3|1|1452052-1452612|CRT
ACTGTACAGTCACTTAAATCTTAAAGTACAAAAAAG	GGGTTGTGCTTTCCGTCCAAAACTGCTCA
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	AGCGTGTTGATCCGTTAGCTTTAAAATCAA
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	ACATCATCAATTCTGTATCAGCATTAATGC
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	CAACGGTGCTGTCTGTGAACTTGTTTTCT
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	AGACAATTAAGCTAAATTCAGCCCCGCCGT
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	AGTAGTGCACCCACCCAGGACGTTTCAGC
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	AGACGTTAGCGCGTATCAGCCTGGCGACTT
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	ACCTCTTGATGTTGAAGGAAAGGTGAAAAT
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC

>NZ_LS483366|3|1|1452117-1452612|PILER-CR
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	AGCGTGTTGATCCGTTAGCTTTAAAATCAA
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	ACATCATCAATTCTGTATCAGCATTAATGC
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	CAACGGTGCTGTCTGTGAACTTGTTTTCT
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	AGACAATTAAGCTAAATTCAGCCCCGCCGT
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	AGTAGTGCACCCACCCAGGACGTTTCAGC
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	AGACGTTAGCGCGTATCAGCCTGGCGACTT
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC	ACCTCTTGATGTTGAAGGAAAGGTGAAAAT
GTTGTACAGTTACTTAAATCTTGAGAGTACAAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LS483366.1\|WP_004182385.1\|1458742_1459678_+\|IS30-family-transposase	unknown	unknown	gnl\|CDD\|225382
NZ_LS483366.1\|WP_084871438.1\|1455137_1458557_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187774
NZ_LS483366.1\|WP_002885965.1\|1444724_1445123_-\|DUF948-domain-containing-protein	unknown	unknown	gnl\|CDD\|227109
NZ_LS483366.1\|WP_084871433.1\|1444271_1444712_-\|YtxH-domain-containing-protein	unknown	unknown	gnl\|CDD\|378938
NZ_LS483366.1\|WP_049528653.1\|1450288_1451191_+\|permease	unknown	unknown	gnl\|CDD\|223773
NZ_LS483366.1\|WP_084871102.1\|1443243_1444230_+\|IS30-family-transposase	unknown	unknown	gnl\|CDD\|225382
NZ_LS483366.1\|WP_061652218.1\|1461673_1462288_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378302
NZ_LS483366.1\|WP_084871440.1\|1463051_1463663_-\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_LS483366.1\|WP_084871514.1\|1463766_1464129_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LS483366.1\|WP_013990847.1\|1462383_1463025_-\|lipase	unknown	unknown	gnl\|CDD\|238879
NZ_LS483366.1\|WP_049528648.1\|1452675_1453728_-\|hypothetical-protein	csn2	cd12217_csn2_CAS-II-A	gnl\|CDD\|213410
NZ_LS483366.1\|WP_002885986.1\|1447095_1447359_-\|PspC-domain-containing-protein	unknown	unknown	gnl\|CDD\|224894
NZ_LS483366.1\|WP_004182780.1\|1446038_1446968_-\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
NZ_LS483366.1\|WP_002946754.1\|1453724_1454048_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NZ_LS483366.1\|WP_084871435.1\|1447424_1447865_-\|SprT-family-protein	unknown	unknown	gnl\|CDD\|235290
NZ_LS483366.1\|WP_004182779.1\|1445247_1446039_-\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
NZ_LS483366.1\|WP_084871437.1\|1451190_1452006_+\|TIGR03943-family-protein	unknown	unknown	gnl\|CDD\|226214
NZ_LS483366.1\|WP_084871439.1\|1459764_1461426_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|183265
NZ_LS483366.1\|WP_084871436.1\|1447851_1449984_-\|RNA-binding-transcriptional-accessory-protein	unknown	unknown	gnl\|CDD\|225094
NZ_LS483366.1\|WP_111686630.1\|1454049_1454961_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851

Protein	Function_ID	Function_description	E-value
NZ_LS483366.1\|WP_004182385.1\|1458742_1459678_+\|IS30-family-transposase	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	5.46217e-105
NZ_LS483366.1\|WP_084871438.1\|1455137_1458557_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|187774	cd09643, Csn1, CRISPR/Cas system-associated protein Cas9. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Very large protein containing McrA/HNH-nuclease related domain and a RuvC-like nuclease domain; signature gene for type II.	0
NZ_LS483366.1\|WP_002885965.1\|1444724_1445123_-\|DUF948-domain-containing-protein	gnl\|CDD\|227109	COG4768, COG4768, Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only].	3.30131e-33
NZ_LS483366.1\|WP_084871433.1\|1444271_1444712_-\|YtxH-domain-containing-protein	gnl\|CDD\|378938	pfam12732, YtxH, YtxH-like protein. This family of proteins is found in bacteria. Proteins in this family are typically between 100 and 143 amino acids in length. The N-terminal region is the most conserved. Proteins is this family are functionally uncharacterized.	4.40747e-08
NZ_LS483366.1\|WP_049528653.1\|1450288_1451191_+\|permease	gnl\|CDD\|223773	COG0701, COG0701, Predicted permeases [General function prediction only].	1.62683e-77
NZ_LS483366.1\|WP_084871102.1\|1443243_1444230_+\|IS30-family-transposase	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	1.29563e-90
NZ_LS483366.1\|WP_061652218.1\|1461673_1462288_-\|hypothetical-protein	gnl\|CDD\|378302	pfam09911, DUF2140, Uncharacterized protein conserved in bacteria (DUF2140). This domain, found in various hypothetical prokaryotic proteins, has no known function.	0.000272037
NZ_LS483366.1\|WP_084871440.1\|1463051_1463663_-\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	9.70303e-10
NZ_LS483366.1\|WP_013990847.1\|1462383_1463025_-\|lipase	gnl\|CDD\|238879	cd01841, NnaC_like, NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles two of the three components of typical Ser-His-Asp(Glu) triad from other serine hydrolases. E. coli NnaC appears to be involved in polysaccharide synthesis.	6.74165e-36
NZ_LS483366.1\|WP_049528648.1\|1452675_1453728_-\|hypothetical-protein	gnl\|CDD\|213410	cd12217, Stu0660_Csn2, Stu0660-like CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. This family of Csn2 proteins includes Stu0660, the proteins are larger than other (canonical) Csn2 proteins as they have an additional alpha-helical C-terminal domain. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	3.34795e-129
NZ_LS483366.1\|WP_002885986.1\|1447095_1447359_-\|PspC-domain-containing-protein	gnl\|CDD\|224894	COG1983, PspC, Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms].	4.4796e-18
NZ_LS483366.1\|WP_004182780.1\|1446038_1446968_-\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	2.9141e-169
NZ_LS483366.1\|WP_002946754.1\|1453724_1454048_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	1.0368e-27
NZ_LS483366.1\|WP_084871435.1\|1447424_1447865_-\|SprT-family-protein	gnl\|CDD\|235290	PRK04351, PRK04351, SprT family protein.	1.31587e-85
NZ_LS483366.1\|WP_004182779.1\|1445247_1446039_-\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	1.24377e-99
NZ_LS483366.1\|WP_084871437.1\|1451190_1452006_+\|TIGR03943-family-protein	gnl\|CDD\|226214	COG3689, COG3689, Predicted membrane protein [Function unknown].	7.08107e-106
NZ_LS483366.1\|WP_084871439.1\|1459764_1461426_-\|STAS-domain-containing-protein	gnl\|CDD\|183265	PRK11660, PRK11660, putative transporter; Provisional.	0
NZ_LS483366.1\|WP_084871436.1\|1447851_1449984_-\|RNA-binding-transcriptional-accessory-protein	gnl\|CDD\|225094	COG2183, Tex, Transcriptional accessory protein [Transcription].	0
NZ_LS483366.1\|WP_111686630.1\|1454049_1454961_-\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	2.12644e-134

>NZ_LS483366.1|WP_084871437.1|1451190_1452006_+|TIGR03943-family-protein
MLRFLILSGYFELVMYLQVSGKLNQYINIHYSYLAYISMVLSFILAVVQLIVWMKQMKVHSHLSGRVAKVASIVLLAFPVLTGLLVPTVTLDANTVSAKGYHFPLAAGSDSNQADQEGTTIQYLKPDTSSYFTSSAYEKEMTRELAKYKGRETIQITTENYMEVMELIYLYPNDFVGKKVTYTGFVYNDPQTKGYQFIFRFGIIHCIADSGVYGLATTGSDQTFKDNTWVKVTGTITVDYYQNLKQSLPILNLTEVKEVGQPDNPYVYRVF
>NZ_LS483366.1|WP_049528653.1|1450288_1451191_+|permease
MAIFHQLPDSVLQLLAVFLSIIIEALPFVLLGSILSGFIEVFVTPEKVQNFLPKNKVLAILFGTLIGFIFPSCECGIVPIITRFLEKKVPSYTAIPFMATAPIINPVVLFATYTAFGNSWYYVLLRFVGAFLIAMILGILLGFVVDDQILKDNRKVSHVHDYSGLSAGKKTFQALVHAVDEFFDTGRYLIFGSLVAASMQTYLPTRILTTIGHNSVTAILIMMLLAFILSLCSEADAFIGASLLSSFGVAPTVAFLIIGPMVDIKNLIMMKHQFKTRFVGLFVGTASLATIIYCLVLGVI
>NZ_LS483366.1|WP_084871436.1|1447851_1449984_-|RNA-binding-transcriptional-accessory-protein
MENRNLETLAQELGLKKQQVETVLELTAEGNTIPFIARYRKEKTGNLDETQIKAIIDMDKSLTALQDRKETVLAKIEAQGKLTDQLKAAIEAAEKLADVEELYLPYKEKRRTKATVAREAGLFPLARLILQNSPNLKAEAEKLTSEAFPTADKALAGAVDILVEAFSEDNSLRSWTYNEIWNNSDITSTLKDQSLDEKETFKIYYDFEDKVSKLQGYRTLALNRGEKLGVIKVAFKHNLEKMHRFYSARFKQKNDYIEEVINQSLKKKIIPAMERRIRSELTEAAEDGAIQLFSQNLRSLLLVSPLKGKMVLGFDPAFRTGAKLAVVDQTGKLITTQVIYPVAPASQAKIAQAKKDLADLIKKHAIEIIAIGNGTASRESEAFVAEVLKDFPETSYVIVNESGASVYSASELARHEFPDLTVEKRSAISIARRLQDPLAELVKIDPKSIGVGQYQHDVSQKKLSENLDFVVDTVVNQVGVNVNTASSTLLSHVSGLNKTISENIVAYREENGEIASRAEIKKVPRLGAKAFEQAAGFLRIPNAKNILDNTGVHPESYPAVKALFKQLAITDLDDSAKAKLKALNLKETAEGLGLGQETLKDIIADLLKPGRDLRDDFEAPVLRQDVLELKDLSVGQKLEGTVRNVVDFGAFVDIGVHEDGLIHISEMSKSFVNHPSQVVSVGDLVTVWVSKVDLEHEKLNLSLVNPRESN
>NZ_LS483366.1|WP_084871435.1|1447424_1447865_-|SprT-family-protein
MNLTDYVKTVSIEDFGWEFKHQALWNKRLRTTGGRFFPKDGHLDFNPKLYEEHGLETFRKIVRHELCHYHLYFQGKGYKHADRDFKDLLAKVDGLRYAPKMQGQEENYYLYQCQSCGHTYRRKRRVNTQKFGCGLCRGKLIFLNQS
>NZ_LS483366.1|WP_002885986.1|1447095_1447359_-|PspC-domain-containing-protein
MSNRFYKTRKNRLVAGVVAGLADKFGWDLALARILAIILMVSTQFGIFLYLVLAFLLPYKEDIYPEIKLKDGRKRKNAEPVEDEWNW
>NZ_LS483366.1|WP_004182780.1|1446038_1446968_-|HPr-kinase/phosphorylase
MTVTVKMLVDKLKLKVIYGNEKLLSKPITTADISRPGLEMTGYFDFYSPERIQLVGMKEWSYLKTLTDHNRYSVFSNMFKEETPAVIVARGLDIPEEMYRAAKENGVAVLQGRNGTSSLSGDMSWYLNAQLAERTSVHGVLVDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDVYAKDEETLWGEPAEILRHLLEIRGVGIIDVMSLYGASAVRNSSQVQLAIYLENFEDGKVFDRLGNGNEEIELQGVKIPRVRIPVKTGRNVSVVIEAAAMNYRAKQMGFDATKTFEERLTNLISKNGED
>NZ_LS483366.1|WP_004182779.1|1445247_1446039_-|prolipoprotein-diacylglyceryl-transferase
MFATIDPIALRLGPISIHWYAICIVSGLLLAVYLAQRWAPEKGIDPENILDFILLAFPIAIVGARLYYVIFQWSYYSQNPSEIFAIWNGGIAIYGGLIAGAAVLYWFAKRHAIAVLDFLDIAAPGVMIAQSIGRWGNFINQEAYGKAVSHLNYVPEFIRQQMYIDGSYRVPTFLYESLWNLVGFIIILGLRRFNKKLRQGDVTSFYLIWYGLGRFVIEGMRTDSLMFVGLRVSQWVSIAIIILGATLLYLRKQRPEADYKMKN
>NZ_LS483366.1|WP_002885965.1|1444724_1445123_-|DUF948-domain-containing-protein
MAEIAFLIIAIALAAFLIALIPTLLRTRHVVKEVEETVAVLRTDINVTLHQTNEILAKANVLVEDVNEKVQTIDPLFVAVAELSESVSDLNTEARYLGAKASAAGASVGKAGSAFAIGKVASKLFGKKDKKK
>NZ_LS483366.1|WP_084871433.1|1444271_1444712_-|YtxH-domain-containing-protein
MSKFLNTLIIGVASGAAAAYFFTTEKGKAVKARIDEEIASFKEDPKAYQNQVVEKASDYKDLAVDTFQDYKTKFENGDITADDLTKAVQEKTAQVADFAKESFELIKEKTAQVTPEQADVEAETKAIVDDIVIDIKDISEEATEAK
>NZ_LS483366.1|WP_084871102.1|1443243_1444230_+|IS30-family-transposase
MSYHHFTIDERESILIYRTQGLNFSQIAKLLHRHPSSISREWKRHTKSGAYSPNHAQESYHMAKSHCGRKRMLEIDHNLSNTVKHLFLDYQWSPEEIEGRLQLEYGKTVISYQTIYRAIYRGHFEDNSLSHGARGVIRKLRHRGKTRHTKGHVENRGKISISHTIHERPEEANNRTRIGDWEADTVAGKTGKACLVTLTDRYSRFLKIKKVAVKKSKLVIEAMVKMLEPLTKYTVTPDRGKEFTYHQKLSDQLNIEVYFPDPHAPWQRGTNENTNGLLREYFPKGSDLTLVDDQTIQLWENKLNNRPRKCLNWKTPYEVFYGESMHLI
>NZ_LS483366.1|WP_049528648.1|1452675_1453728_-|hypothetical-protein
MKFFVQHPYKERIELNIGAITQIVGQNKELKYYIWQILSWYFGGKKYSSDDLSIFDYEEPTILDESGEIVKRSSYHYIEISSFKDLLEQMEYKKGTLAHGYLGKIVNQVDIVAHLEKINEQVELIEGAMNQHINLNSGKVEYHLENRSLTLDQLLSKNFSPFFAIENKNLSFEWVSNTDKLSLFLEMLDRLLSQTTEKYLIVLKNIDSFISEESYDSFYKQIGQLVKKYPNLNLILFPSNQGYLKIDEENSRFVNILSDQVEHLYDIEFMYDRVKKHYPSNNFPPREGFRKSLENVTPYLLTKMLRQPSLTLVDSVILNILNQLFQFNYRIRYSQTPDEELLHRYLESKN
>NZ_LS483366.1|WP_002946754.1|1453724_1454048_-|CRISPR-associated-endonuclease-Cas2
MRYEALRLLCFFDLPMESKDEKRIYRNFRKELISNGFEMLQFSVYYRTCPNRSFANKFYKKLKMSNLPAGNVRLLAVTEKQFSEMTLIIGGKTKQEEIVSDNKLVVI
>NZ_LS483366.1|WP_111686630.1|1454049_1454961_-|type-II-CRISPR-associated-endonuclease-Cas1
MTWRVVHVSQSEKMRLKLDNLLVQKMGQEFTVPLSDISIIVAEGGDTVVNLRLLSALSKYNIALVVCDNEHLPTGIYHSQNGHFRAYKRLKEQMDWSQKQKDKAWQIVTYYKINNQEDVLAMFEKSLDNIRLLSDYKEQIEPGDRTNREGHAAKVYFNELFGKQFVRVTQQEADVINAGLNYGYAIMRAQMARIVAGYGLNGLLGIFHKNEYNQFNLVDDLMEPFRQIVDVWVYDNLRDQEFLKYEYRLGLTDLLNAKIKYGKETCSVTVAMDKYVKGFIKYISEKDSSKFHCPVVSSLEWRK
>NZ_LS483366.1|WP_084871438.1|1455137_1458557_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MSDLVLGLDIGIGSVGVGILNKVTGEIIHKNSRIFPAAQAENNVERRTNRQGRRLTRRKKHRRVRLNHLFEESGLITDFTQVSINLNPYQLRVKGLTDELSNEELFIALKNMVKHRGISYLDDASDDGNSSVGDYAQIVKENSKQLETKTPGQIQLERYQKYGQLRGDFTIEEDGKKHRLINVFPTSAYRAEALRILQTQQEFNPQITDEFINSYLQILTGKRKYYHGPGNEKSRTDYGRYTTKKDSEDEYLTLDNIFGILIGKCTFYPEEYRAAKASYTAQEFNLLNDLNNLTVPTETKKLSEEQKNKIITYVKNEKAMGPAKLFKYIAKLLSCDVADIKGYRIDKSDKAEIHTFEAYRKMKTLETIDIEQMEREKLDKLAYVLTLNTEKEGIQEALEHEFADGTFSQKQVDELVQFRKANSSIFGKGWHNFSVKLMMELIPELYATSEEQMTILTRLGKQKTTSSSNKTKYIDEKRLTEEIYNPVVAKSVRQAIKIVNAAIKEYSDFDNIVIEMARETNEDDEKKAIQKIQKANKDEKDAAMLKAANQYNGKAELPHSVFHGHKQLATKIRLWHQQGERCLYTGKTISIHDLINNPNQFEIDHILPLSITFDDSLANKVLVYATANQEKGQRTPYQALDSMDDAWSFRELKAFVRESKTLSNKKKEYLLTEEDISKFDVRKKFIERNLVDTRYASRVVLNALQEHFRTRKIDTKVSVVRGQFTSQLRRHWGIDKIRDTYHHHAVDALIIAASSQLNLWKKQKNTLVSYSEDQLLDIETGELISDDEYKESVFKAPYQHFVDTLKSKDFEDSILFSYQVDSKFNRKISDATIYATRKAKLDKEKKEYTYTLGKIKDIYALGTKTPSKTGFYKFLDLYKKDKSQFLMYQKDRKTWDEVIEKILEQYRPFKEKDKNGKEVDFNPFEKYRIENGPIRKYSRKGNGPEIKSLKYYDNLLGRFVDITPSESKNPVALLSLNPWRTDVYYNTETRKYEFLGLKYADLCFEKGGSYGISKVKYNKIREKEGIGKNSEFKFTLYKNDLILIKDTETNRQQIFRFWSRTGKDNPKSFEKHKIELKPYEKARFEKGEELEVLGKVPPSSNQLQKNMQIENLSIYKVRTDVLGNQHIIKNEGDKPKLDF
>NZ_LS483366.1|WP_004182385.1|1458742_1459678_+|IS30-family-transposase
MSYSHLTITDRIKIETYLDLGLKPCQIASKLSVHKSTISRELRRCQNGYSAVLAQEQYDHRAKQKGRKSRLTPKLKKEIEDGLKSSWSPEQICGRYQLEQKPMVAFKTIYNWLYAGLIDLDLSVLRRKGKTRQPKETRGTFRIGTSIAKRPKEVRNRETFGHWELDTVVSSRGKSKGCLATFLERKTRFYLAFKIPDRTAKSMFSAIEQLCKLFPKEALKTFTSDRGKEFACYPLVENLGIPFFFADAYSSWQRGGNENANGLLREYFPKKTDLAAISEEALTKALYDINHRPRKCLAYRTACEALEDEFE
>NZ_LS483366.1|WP_084871439.1|1459764_1461426_-|STAS-domain-containing-protein
MDALKYITPKFFTTIKDYSKGQFIKDLVAGVIVAIIALPLSIALAIASGVNPEQGLYTAVVAGFFISFLGGSRVQIGGPTAAFVVIIYGIIAQYGMAGLTVATLMAGLMLIIMGLLRFGDLIKFIPKTITLGFTLGIAVGIVAGQIKDFLGLEMKSVPAEFLEKMIAYGKHLSSISWATLAIGILALLIQIFWPRLSKKIPGSLVAIFVTTAIVAFGHLPVKTIGDLYTIKAGLPSFTVPDLSFSLIRQMISPAFTIAILAAIESLLSCVVSDGMIGGNHRSNAELVGQGVGNIMSALFGGIPATGAIARTAANVKNGGRTPVAGMVHAFTLLLILLFLMPYASLIPMTCLASILMIVGYNMSGWRTVGRMIKRAPKSDVAVLLVTFVLTVFFDLVVAIEFGMVLAAFLFLKRMSDVAQIRQWVDKENLDDPVLSEDSDLKQVPKNTVVYEVFGALFFGAANNFLNVINDETKNVLILRMRNVPAMDISGLDALEETLAICQKRGMTLLLSHVNAQPYRVLEKSGFIQTIGADHICESTDQALEKAAALAKEA
>NZ_LS483366.1|WP_061652218.1|1461673_1462288_-|hypothetical-protein
MWKWFKRLIVLVIVLFFAVAALLIPDKIDSQDQLKNVSTQTSLADLAQAGIGGASLSSGGVSTEINLDSNQFRQILKASMADSNDETLLNSTVELNDSYLTAKLPVSLGPIESTFSLDFTVSTNKEVILLDLAGAHLGRLPVPKSLVLPYLKKSIAQSSSGVRMVNNQIQLKLPEIGYEIEQATVTNSKMKVKLNIPISLPTSW
>NZ_LS483366.1|WP_013990847.1|1462383_1463025_-|lipase
MDELKEIKLKNYQYLNEVAIKGETLFTGSSLMELFPICEIARSRGVDDIIYNRGISGLNTDEFLQHIHPLLLDLQPSKVFINIGTNDMTEEPYGDQWFQHLTANIRQILEQTQAVLPHTKIYLMAFYPANLHLPWQTKASIQWMKLRTTENLDRCNQALEEIAQTYGCHFINCNAGLVNDRKEQKAEHTYDGVHLYANAYLKVYEALEPYLLN
>NZ_LS483366.1|WP_084871440.1|1463051_1463663_-|CPBP-family-intramembrane-metalloprotease
MTLFISKLMNGIMELLIVSVIPFITWLIWSRKKVGFFDWIGLKKVESQQKRRLLLTILGISLLFLLFSIVVFSWFDSSQTATAAFSGKGIGALPAILAYAILGTALPEEIFFRGFLLKRLQGKLGFLGANLVQSLLFGLIHALMFIQLTGYLKAMAIMAFISLIAYVFGAINEKKAGGSILPSVFIHALANTVVGLLFAFSLV
>NZ_LS483366.1|WP_084871514.1|1463766_1464129_-|hypothetical-protein
MAHLTPETRRKRRKAFCLIIEIICLVHFAIIVPRDRVFTPENWAHTPAPMRHKLMWSFHRQYQLEDMTREKVEKLLGKGNDLKGSVEYQLADDWIGGWRVYHIDYEQGRVIRAKETWQDW

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_LS483366_3	3.2\|1452153\|30\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452153-1452182	30	MK448524	Streptococcus satellite phage Javan537, complete genome	984-1013	1	0.967
NZ_LS483366_3	3.2\|1452153\|30\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452153-1452182	30	MK448528	Streptococcus satellite phage Javan541, complete genome	984-1013	1	0.967
NZ_LS483366_3	3.2\|1452153\|30\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452153-1452182	30	MK448527	Streptococcus satellite phage Javan540, complete genome	984-1013	1	0.967
NZ_LS483366_3	3.4\|1452285\|29\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452285-1452313	29	MK448979	Streptococcus phage Javan534, complete genome	8273-8301	1	0.966
NZ_LS483366_3	3.4\|1452285\|29\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452285-1452313	29	MK448799	Streptococcus phage Javan535, complete genome	8273-8301	1	0.966
NZ_LS483366_3	3.4\|1452285\|29\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452285-1452313	29	MK448800	Streptococcus phage Javan539, complete genome	8274-8302	1	0.966
NZ_LS483366_3	3.2\|1452153\|30\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452153-1452182	30	MK448601	Streptococcus satellite phage Javan653, complete genome	984-1013	2	0.933
NZ_LS483366_3	3.2\|1452153\|30\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452153-1452182	30	MK448577	Streptococcus satellite phage Javan614, complete genome	984-1013	3	0.9
NZ_LS483366_3	3.4\|1452285\|29\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452285-1452313	29	MK448718	Streptococcus phage Javan253, complete genome	9175-9203	3	0.897
NZ_LS483366_3	3.5\|1452350\|30\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452350-1452379	30	MK448980	Streptococcus phage Javan536, complete genome	9769-9798	3	0.9
NZ_LS483366_3	3.4\|1452285\|29\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452285-1452313	29	MK448817	Streptococcus phage Javan59, complete genome	11534-11562	4	0.862
NZ_LS483366_3	3.2\|1452153\|30\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452153-1452182	30	MK448529	Streptococcus satellite phage Javan542, complete genome	963-992	5	0.833
NZ_LS483366_3	3.2\|1452153\|30\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452153-1452182	30	MK448362	Streptococcus satellite phage Javan209, complete genome	960-989	5	0.833
NZ_LS483366_3	3.2\|1452153\|30\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452153-1452182	30	MK448531	Streptococcus satellite phage Javan544, complete genome	963-992	5	0.833
NZ_LS483366_3	3.2\|1452153\|30\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452153-1452182	30	MK448361	Streptococcus satellite phage Javan208, complete genome	960-989	5	0.833
NZ_LS483366_3	3.3\|1452219\|30\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452219-1452248	30	NZ_CP022300	Acinetobacter johnsonii strain IC001 plasmid pIC001B, complete sequence	2519-2548	6	0.8
NZ_LS483366_3	3.4\|1452285\|29\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452285-1452313	29	NZ_CP046163	Vibrio sp. THAF191c plasmid pTHAF191c_b, complete sequence	1139182-1139210	6	0.793
NZ_LS483366_3	3.4\|1452285\|29\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452285-1452313	29	NZ_CP046066	Vibrio sp. THAF191d plasmid pTHAF191d_b, complete sequence	1322574-1322602	6	0.793
NZ_LS483366_3	3.4\|1452285\|29\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452285-1452313	29	NZ_CP045356	Vibrio sp. THAF64 plasmid pTHAF64_a, complete sequence	437338-437366	6	0.793
NZ_LS483366_3	3.2\|1452153\|30\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452153-1452182	30	AP013510	Uncultured Mediterranean phage uvMED DNA, complete genome, group G20, isolate: uvMED-CGR-C101A-MedDCM-OCT-S30-C6	3735-3764	7	0.767
NZ_LS483366_3	3.2\|1452153\|30\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452153-1452182	30	AP013876	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C101A-MedDCM-OCT-S39-C9, * SEQUENCING IN PROGRESS *	12907-12936	7	0.767
NZ_LS483366_3	3.3\|1452219\|30\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452219-1452248	30	NC_011246	Borrelia recurrentis A1 plasmid pl124, complete sequence	47296-47325	7	0.767
NZ_LS483366_3	3.3\|1452219\|30\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452219-1452248	30	NC_011247	Borrelia duttonii Ly plasmid pl165, complete sequence	85484-85513	7	0.767
NZ_LS483366_3	3.8\|1452547\|30\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452547-1452576	30	NZ_CP019718	Paenibacillus larvae subsp. larvae strain Eric_V plasmid unnamed1, complete sequence	2921-2950	7	0.767
NZ_LS483366_3	3.2\|1452153\|30\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452153-1452182	30	MK448572	Streptococcus satellite phage Javan61, complete genome	963-992	8	0.733
NZ_LS483366_3	3.3\|1452219\|30\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452219-1452248	30	MH319757	Marine virus AG-345-O18 Ga0172273_11 genomic sequence	62022-62051	8	0.733
NZ_LS483366_3	3.8\|1452547\|30\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452547-1452576	30	MN693386	Marine virus AFVG_25M538, complete genome	18635-18664	8	0.733
NZ_LS483366_3	3.8\|1452547\|30\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452547-1452576	30	MN693115	Marine virus AFVG_25M537, complete genome	23940-23969	8	0.733
NZ_LS483366_3	3.3\|1452219\|30\|NZ_LS483366\|CRISPRCasFinder,CRT,PILER-CR	1452219-1452248	30	MT349887	Acinetobacter phage 5W, complete genome	28291-28320	9	0.7

1. spacer 3.2|1452153|30|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to MK448524 (Streptococcus satellite phage Javan537, complete genome) position: , mismatch: 1, identity: 0.967

agcgtgttgatccgttagctttaaaatcaa	CRISPR spacer
agcgtgttgatccattagctttaaaatcaa	Protospacer
*************.****************

2. spacer 3.2|1452153|30|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to MK448528 (Streptococcus satellite phage Javan541, complete genome) position: , mismatch: 1, identity: 0.967

agcgtgttgatccgttagctttaaaatcaa	CRISPR spacer
agcgtgttgatccattagctttaaaatcaa	Protospacer
*************.****************

3. spacer 3.2|1452153|30|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to MK448527 (Streptococcus satellite phage Javan540, complete genome) position: , mismatch: 1, identity: 0.967

agcgtgttgatccgttagctttaaaatcaa	CRISPR spacer
agcgtgttgatccattagctttaaaatcaa	Protospacer
*************.****************

4. spacer 3.4|1452285|29|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to MK448979 (Streptococcus phage Javan534, complete genome) position: , mismatch: 1, identity: 0.966

caacggtgctgtctgtgaacttgttttct	CRISPR spacer
caacggtgctgtctgtgagcttgttttct	Protospacer
******************.**********

5. spacer 3.4|1452285|29|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to MK448799 (Streptococcus phage Javan535, complete genome) position: , mismatch: 1, identity: 0.966

caacggtgctgtctgtgaacttgttttct	CRISPR spacer
caacggtgctgtctgtgagcttgttttct	Protospacer
******************.**********

6. spacer 3.4|1452285|29|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to MK448800 (Streptococcus phage Javan539, complete genome) position: , mismatch: 1, identity: 0.966

caacggtgctgtctgtgaacttgttttct	CRISPR spacer
caacggtgctgtctgtgagcttgttttct	Protospacer
******************.**********

7. spacer 3.2|1452153|30|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to MK448601 (Streptococcus satellite phage Javan653, complete genome) position: , mismatch: 2, identity: 0.933

agcgtgttgatccgttagctttaaaatcaa	CRISPR spacer
aacgtgttgatccattagctttaaaatcaa	Protospacer
*.***********.****************

8. spacer 3.2|1452153|30|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to MK448577 (Streptococcus satellite phage Javan614, complete genome) position: , mismatch: 3, identity: 0.9

agcgtgttgatccgttagctttaaaatcaa	CRISPR spacer
aacgtgttgagccattagctttaaaatcaa	Protospacer
*.******** **.****************

9. spacer 3.4|1452285|29|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to MK448718 (Streptococcus phage Javan253, complete genome) position: , mismatch: 3, identity: 0.897

caacggtgctgtctgtgaacttgttttct	CRISPR spacer
cagtggtgctgtctgtgagcttgttttct	Protospacer
**..**************.**********

10. spacer 3.5|1452350|30|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to MK448980 (Streptococcus phage Javan536, complete genome) position: , mismatch: 3, identity: 0.9

agacaattaagctaaattcagccccgccgt	CRISPR spacer
agacgattaagctaaattcagccccaccat	Protospacer
****.********************.**.*

11. spacer 3.4|1452285|29|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to MK448817 (Streptococcus phage Javan59, complete genome) position: , mismatch: 4, identity: 0.862

caacggtgctgtctgtgaacttgttttct	CRISPR spacer
tagtggtgctgtctgtgaactagttttct	Protospacer
.*..***************** *******

12. spacer 3.2|1452153|30|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to MK448529 (Streptococcus satellite phage Javan542, complete genome) position: , mismatch: 5, identity: 0.833

agcgtgttgatccgttagctttaaaatcaa	CRISPR spacer
tgactgtcgatccgttagttttaaaatcaa	Protospacer
 *  ***.**********.***********

13. spacer 3.2|1452153|30|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to MK448362 (Streptococcus satellite phage Javan209, complete genome) position: , mismatch: 5, identity: 0.833

agcgtgttgatccgttagctttaaaatcaa	CRISPR spacer
atactgttgctccgttagctttaaaagcaa	Protospacer
*   ***** **************** ***

14. spacer 3.2|1452153|30|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to MK448531 (Streptococcus satellite phage Javan544, complete genome) position: , mismatch: 5, identity: 0.833

agcgtgttgatccgttagctttaaaatcaa	CRISPR spacer
tgactgtcgatccgttagttttaaaatcaa	Protospacer
 *  ***.**********.***********

15. spacer 3.2|1452153|30|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to MK448361 (Streptococcus satellite phage Javan208, complete genome) position: , mismatch: 5, identity: 0.833

agcgtgttgatccgttagctttaaaatcaa	CRISPR spacer
atactgttgctccgttagctttaaaagcaa	Protospacer
*   ***** **************** ***

16. spacer 3.3|1452219|30|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP022300 (Acinetobacter johnsonii strain IC001 plasmid pIC001B, complete sequence) position: , mismatch: 6, identity: 0.8

acatcatcaattctgtatcagcattaatgc	CRISPR spacer
acagatgccattctgtatcagcattgatgc	Protospacer
***    * ****************.****

17. spacer 3.4|1452285|29|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP046163 (Vibrio sp. THAF191c plasmid pTHAF191c_b, complete sequence) position: , mismatch: 6, identity: 0.793

caacggtgctgtctgtgaacttgttttct	CRISPR spacer
catcggtgctgtctgtgaacttgacagca	Protospacer
** ******************** .  *

18. spacer 3.4|1452285|29|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP046066 (Vibrio sp. THAF191d plasmid pTHAF191d_b, complete sequence) position: , mismatch: 6, identity: 0.793

caacggtgctgtctgtgaacttgttttct	CRISPR spacer
catcggtgctgtctgtgaacttgacagca	Protospacer
** ******************** .  *

19. spacer 3.4|1452285|29|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP045356 (Vibrio sp. THAF64 plasmid pTHAF64_a, complete sequence) position: , mismatch: 6, identity: 0.793

caacggtgctgtctgtgaacttgttttct	CRISPR spacer
catcggtgctgtctgtgaacttgacagca	Protospacer
** ******************** .  *

20. spacer 3.2|1452153|30|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to AP013510 (Uncultured Mediterranean phage uvMED DNA, complete genome, group G20, isolate: uvMED-CGR-C101A-MedDCM-OCT-S30-C6) position: , mismatch: 7, identity: 0.767

agcgtgttgatccgttagctttaaaatcaa	CRISPR spacer
ctcttagtgatccgtcagctttagaatcaa	Protospacer
  * *. ********.*******.******

21. spacer 3.2|1452153|30|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to AP013876 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C101A-MedDCM-OCT-S39-C9, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.767

agcgtgttgatccgttagctttaaaatcaa	CRISPR spacer
ctcttagtgatccgtcagctttagaatcaa	Protospacer
  * *. ********.*******.******

22. spacer 3.3|1452219|30|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to NC_011246 (Borrelia recurrentis A1 plasmid pl124, complete sequence) position: , mismatch: 7, identity: 0.767

acatcatcaattctgtatcagcattaatgc	CRISPR spacer
aattcatcaatgctttatcagcattatacc	Protospacer
*  ******** ** ***********   *

23. spacer 3.3|1452219|30|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to NC_011247 (Borrelia duttonii Ly plasmid pl165, complete sequence) position: , mismatch: 7, identity: 0.767

acatcatcaattctgtatcagcattaatgc	CRISPR spacer
aattcatcaatgctttatcagcattatacc	Protospacer
*  ******** ** ***********   *

24. spacer 3.8|1452547|30|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP019718 (Paenibacillus larvae subsp. larvae strain Eric_V plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

acctcttgatgttgaaggaaaggtgaaaat	CRISPR spacer
acctctagatgatgaaggaaaggctagatc	Protospacer
****** **** ***********. *.* .

25. spacer 3.2|1452153|30|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to MK448572 (Streptococcus satellite phage Javan61, complete genome) position: , mismatch: 8, identity: 0.733

agcgtgttgatccgttagctttaaaatcaa	CRISPR spacer
taaccgttgatccgttaagtttaaaatcta	Protospacer
 .  .************. ********* *

26. spacer 3.3|1452219|30|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to MH319757 (Marine virus AG-345-O18 Ga0172273_11 genomic sequence) position: , mismatch: 8, identity: 0.733

acat-catcaattctgtatcagcattaatgc	CRISPR spacer
-tatgtatcaattctgtatcagcagtatcta	Protospacer
 .** .****************** ** .

27. spacer 3.8|1452547|30|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to MN693386 (Marine virus AFVG_25M538, complete genome) position: , mismatch: 8, identity: 0.733

acctcttgatgttgaaggaaaggtgaaaat	CRISPR spacer
ccgtcttggtgttgaaggaaaggtcttagc	Protospacer
 * *****.***************   *..

28. spacer 3.8|1452547|30|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to MN693115 (Marine virus AFVG_25M537, complete genome) position: , mismatch: 8, identity: 0.733

acctcttgatgttgaaggaaaggtgaaaat	CRISPR spacer
ccgtcttggtgttgaaggaaaggtcttagc	Protospacer
 * *****.***************   *..

29. spacer 3.3|1452219|30|NZ_LS483366|CRISPRCasFinder,CRT,PILER-CR matches to MT349887 (Acinetobacter phage 5W, complete genome) position: , mismatch: 9, identity: 0.7

acatcatcaattctgtatcagcattaatgc	CRISPR spacer
tagccatcaattcgctatcagcattaaatg	Protospacer
  ..*********  ************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

343312 : 348788

Streptococcus_phage(66.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_045771733.1\|343312_344077_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	4.0e-15	25.2
WP_014633927.1\|344076_344787_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.2e-15	26.9
WP_045771734.1\|344921_345581_+	CBS domain-containing protein	M1NSC5	Streptococcus_phage	1.5e-66	59.2
WP_002883742.1\|345759_346686_-	cysteine synthase A	A0A1X9I5K7	Streptococcus_phage	9.4e-144	81.8
WP_045771735.1\|346787_347414_-	YigZ family protein	A0A1X9I5T8	Streptococcus_phage	1.5e-68	61.8
WP_111686476.1\|347468_348788_+	DEAD/DEAH box helicase	A0A1X9I5S6	Streptococcus_phage	1.4e-121	52.1

DBSCAN-SWA_2

996397 : 1009140

Streptococcus_phage(37.5%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_045768647.1\|996397_998206_+	glutamine--fructose-6-phosphate transaminase (isomerizing)	A7IW18	Paramecium_bursaria_Chlorella_virus	7.3e-100	39.1
WP_002891088.1\|998323_998656_+	alkylphosphonate utilization protein	NA	NA	NA	NA
WP_002891087.1\|998855_999497_+	amino acid ABC transporter permease	NA	NA	NA	NA
WP_002891086.1\|999505_1000135_+	amino acid ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	3.8e-32	40.2
WP_004182424.1\|1000147_1000999_+	amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_070849707.1\|1001112_1002528_+	Y-family DNA polymerase	M1Q231	Streptococcus_phage	6.1e-195	70.7
WP_070578503.1\|1002524_1002902_+	hypothetical protein	A0A1B0RXA8	Streptococcus_phage	1.2e-20	45.0
WP_045772402.1\|1002879_1003161_+	hypothetical protein	M1PG86	Streptococcus_phage	3.0e-21	55.1
WP_045772403.1\|1003296_1004316_+	alcohol dehydrogenase AdhP	A0A2K9L339	Tupanvirus	6.0e-27	25.5
WP_111686571.1\|1004775_1005669_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	2.4e-19	28.5
WP_013990505.1\|1005665_1006406_+	hypothetical protein	NA	NA	NA	NA
WP_070849709.1\|1006398_1006977_+	hypothetical protein	NA	NA	NA	NA
WP_002883901.1\|1007577_1009140_-	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	2.4e-19	30.3

DBSCAN-SWA_3

1218112 : 1279126

Streptococcus_phage(44.44%)

transposase,holin,capsid,integrase,tRNA,protease

attL 1264937:1264952|attR 1273330:1273345

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013990678.1\|1218112_1218586_-\|transposase	IS200/IS605 family transposase	A0A1P8BMC0	Lactococcus_phage	2.0e-17	33.3
WP_111686598.1\|1219272_1219632_-	YbaN family protein	NA	NA	NA	NA
WP_045772120.1\|1219690_1220503_-	MBL fold metallo-hydrolase	A0A0C5AJ83	Bacteriophage	2.1e-38	37.1
WP_013990681.1\|1220508_1221849_-	cell wall metabolism sensor histidine kinase VicK	W8CYF6	Bacillus_phage	1.9e-36	35.3
WP_002884978.1\|1221841_1222549_-	response regulator transcription factor	W8CYM9	Bacillus_phage	1.9e-40	39.6
WP_111686599.1\|1222834_1223602_+	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.3e-37	42.0
WP_014633206.1\|1223611_1224445_+	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_014633207.1\|1224462_1225161_+	amino acid ABC transporter permease	NA	NA	NA	NA
WP_002886253.1\|1225172_1225823_+	amino acid ABC transporter permease	NA	NA	NA	NA
WP_038675884.1\|1226009_1226777_+	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.8e-37	41.1
WP_111686600.1\|1226788_1227622_+	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_014633207.1\|1227639_1228338_+	amino acid ABC transporter permease	NA	NA	NA	NA
WP_002886253.1\|1228349_1229000_+	amino acid ABC transporter permease	NA	NA	NA	NA
WP_049554297.1\|1230640_1231522_-	DNA/RNA non-specific endonuclease	NA	NA	NA	NA
WP_014633209.1\|1231583_1231772_-	DNA-directed RNA polymerase subunit beta	NA	NA	NA	NA
WP_014633210.1\|1231773_1233045_-	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	NA	NA	NA	NA
WP_111686601.1\|1233112_1233349_-	DUF1146 domain-containing protein	NA	NA	NA	NA
WP_013990687.1\|1233670_1234774_-	endoglucanase	NA	NA	NA	NA
WP_014633211.1\|1234782_1236093_-	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_045769136.1\|1236237_1237026_-	hypothetical protein	NA	NA	NA	NA
WP_013990691.1\|1237028_1238180_-	UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	A0A2P1ELS7	Moumouvirus	1.6e-31	29.0
WP_084871400.1\|1241062_1242049_+\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	3.5e-56	39.8
WP_070655716.1\|1242114_1243308_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	5.6e-141	65.4
WP_013990695.1\|1243587_1244526_+	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor	NA	NA	NA	NA
WP_002883500.1\|1244512_1244698_-	DUF3272 family protein	NA	NA	NA	NA
WP_013990696.1\|1244915_1246568_-	DNA polymerase III subunit gamma/tau	A0A1U9WR94	Streptococcus_virus	8.2e-50	42.2
WP_013990697.1\|1246567_1247077_-	GAF domain-containing protein	NA	NA	NA	NA
WP_013990698.1\|1247101_1248013_-\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_003092510.1\|1248088_1248265_+	DUF3042 family protein	NA	NA	NA	NA
WP_013990699.1\|1248643_1248784_-	hypothetical protein	O34062	Streptococcus_phage	2.0e-10	71.7
WP_013990700.1\|1249087_1249330_-	hypothetical protein	NA	NA	NA	NA
WP_014633218.1\|1249535_1250249_-\|capsid	minor capsid protein	A0A286QN48	Streptococcus_phage	9.3e-83	78.2
WP_002883489.1\|1250962_1251310_-	50S ribosomal protein L19	NA	NA	NA	NA
WP_070575970.1\|1251437_1252664_-	voltage-gated chloride channel family protein	A0A1X9I5Z9	Streptococcus_phage	9.0e-102	54.7
WP_037600189.1\|1252660_1252945_-	chorismate mutase	NA	NA	NA	NA
WP_084871402.1\|1253018_1254554_-	chloride channel protein	NA	NA	NA	NA
WP_002883520.1\|1254605_1255049_-	flavodoxin	NA	NA	NA	NA
WP_061652392.1\|1255416_1255788_-	hypothetical protein	NA	NA	NA	NA
WP_004182633.1\|1255799_1256519_-\|protease	matrixin family metalloprotease	NA	NA	NA	NA
WP_037611699.1\|1256638_1257421_-	esterase family protein	NA	NA	NA	NA
WP_084871403.1\|1257555_1259217_-	ribonuclease J	NA	NA	NA	NA
WP_084871404.1\|1259396_1260155_-	ABC transporter ATP-binding protein	A0A1V0SE00	Indivirus	7.7e-11	26.5
WP_002883493.1\|1260151_1261021_-	branched-chain amino acid ABC transporter permease	NA	NA	NA	NA
WP_004182637.1\|1261030_1262032_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_014634335.1\|1262168_1262390_-	DUF4649 family protein	NA	NA	NA	NA
1264937:1264952	attL	NA	NA	NA	NA
WP_111686602.1\|1265160_1265583_-	hypothetical protein	C5IUL6	Streptococcus_phage	9.4e-59	80.0
WP_111686603.1\|1265618_1266170_-	anti-CRISPR protein AcrIIA6	A0A2H4J7D7	uncultured_Caudovirales_phage	4.3e-96	91.3
WP_145959542.1\|1266187_1266460_-	hypothetical protein	NA	NA	NA	NA
WP_070439667.1\|1266479_1266824_-	hypothetical protein	A0A2I6QR21	Streptococcus_phage	2.7e-56	96.5
WP_111686605.1\|1267274_1268021_-	SH3 domain-containing protein	F8HGP2	Streptococcus_phage	1.8e-129	91.5
WP_111686606.1\|1268022_1268319_-\|holin	phage holin	A0A2H4J017	uncultured_Caudovirales_phage	1.7e-30	67.4
WP_014634349.1\|1268399_1268588_-	helix-turn-helix transcriptional regulator	Q708Q8	Streptococcus_phage	2.8e-07	53.4
WP_111686607.1\|1268755_1268959_+	hypothetical protein	M1PLB3	Streptococcus_phage	4.1e-20	79.1
WP_172453857.1\|1268936_1269101_-	hypothetical protein	NA	NA	NA	NA
WP_111686608.1\|1269119_1269356_-	DUF739 family protein	A0A2P0VIW8	Streptococcus_phage	1.9e-24	78.3
WP_111686609.1\|1269524_1269908_+	helix-turn-helix domain-containing protein	O34035	Streptococcus_phage	1.2e-31	56.7
WP_111686610.1\|1269909_1270797_+	Abi family protein	NA	NA	NA	NA
WP_111686611.1\|1270955_1271333_+	ImmA/IrrE family metallo-endopeptidase	W6LM52	Streptococcus_phage	7.9e-57	88.5
WP_111686612.1\|1271326_1271965_+	hypothetical protein	A0A2H4J009	uncultured_Caudovirales_phage	3.4e-60	76.4
WP_111686613.1\|1272099_1273272_+\|integrase	site-specific integrase	A0A1S5S8R9	Streptococcus_phage	1.1e-101	52.0
WP_004182640.1\|1273329_1274832_-	pyruvate kinase	NA	NA	NA	NA
1273330:1273345	attR	NA	NA	NA	NA
WP_084871405.1\|1274902_1275922_-	6-phosphofructokinase	NA	NA	NA	NA
WP_084871406.1\|1276015_1279126_-	DNA polymerase III subunit alpha	A0A2L1IZ23	Streptomyces_phage	2.0e-113	28.8

DBSCAN-SWA_4

1411714 : 1463663

Staphylococcus_phage(50.0%)

tRNA,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002884129.1\|1411714_1412614_-\|protease	zinc metalloprotease HtpX	NA	NA	NA	NA
WP_004182745.1\|1412615_1413176_-	LemA family protein	NA	NA	NA	NA
WP_070850424.1\|1413324_1414329_-	DNA/RNA non-specific endonuclease	NA	NA	NA	NA
WP_014633314.1\|1414470_1417767_-	YSIRK-type signal peptide-containing protein	NA	NA	NA	NA
WP_004182385.1\|1417911_1418847_-\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	4.0e-86	54.0
WP_070850420.1\|1419358_1420246_-\|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA
WP_070850418.1\|1420330_1421416_-	HigA family addiction module antidote protein	NA	NA	NA	NA
WP_070850416.1\|1421408_1421747_-	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_111686627.1\|1421952_1423647_-	DUF2075 domain-containing protein	NA	NA	NA	NA
WP_070846935.1\|1423656_1423986_-	nucleotide pyrophosphohydrolase	NA	NA	NA	NA
WP_111686628.1\|1424242_1425010_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_111686629.1\|1425040_1426198_-	DUF2974 domain-containing protein	NA	NA	NA	NA
WP_061652210.1\|1426307_1426934_+	Pr6Pr family membrane protein	NA	NA	NA	NA
WP_004182763.1\|1427964_1428354_+	hypothetical protein	NA	NA	NA	NA
WP_013990823.1\|1428544_1429447_+	N-acetylmuramoyl-L-alanine amidase	A9QTG1	Bacillus_phage	3.6e-23	35.7
WP_013990824.1\|1429559_1430033_+\|tRNA	aminoacyl-tRNA deacylase	NA	NA	NA	NA
WP_013990825.1\|1430035_1430674_+	histidine phosphatase family protein	NA	NA	NA	NA
WP_013990826.1\|1430823_1431726_-	HAD family hydrolase	NA	NA	NA	NA
WP_004182767.1\|1432045_1432525_-	hypothetical protein	NA	NA	NA	NA
WP_061652213.1\|1432538_1433792_-	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_073687074.1\|1434019_1435510_+\|tRNA	lysine--tRNA ligase	A0A2K9L3L6	Tupanvirus	2.3e-91	39.5
WP_004182770.1\|1436118_1436997_+	hypothetical protein	NA	NA	NA	NA
WP_004182771.1\|1437295_1438630_+	Nramp family divalent metal transporter	NA	NA	NA	NA
WP_004182772.1\|1438666_1438879_-	hypothetical protein	NA	NA	NA	NA
WP_004182773.1\|1439003_1439288_+	hypothetical protein	NA	NA	NA	NA
WP_014633328.1\|1439382_1439922_+	biotin transporter BioY	NA	NA	NA	NA
WP_073687076.1\|1439967_1440285_-	hypothetical protein	NA	NA	NA	NA
WP_049528881.1\|1440284_1441571_-	U32 family peptidase	Q6DW11	Phage_TP	1.2e-40	32.1
WP_002886038.1\|1441666_1442596_-	U32 family peptidase	NA	NA	NA	NA
WP_002886140.1\|1442834_1443131_+	DUF3270 domain-containing protein	NA	NA	NA	NA
WP_084871102.1\|1443243_1444230_+\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	4.2e-57	40.1
WP_084871433.1\|1444271_1444712_-	YtxH domain-containing protein	NA	NA	NA	NA
WP_002885965.1\|1444724_1445123_-	DUF948 domain-containing protein	NA	NA	NA	NA
WP_004182779.1\|1445247_1446039_-	prolipoprotein diacylglyceryl transferase	NA	NA	NA	NA
WP_004182780.1\|1446038_1446968_-	HPr kinase/phosphorylase	NA	NA	NA	NA
WP_002885986.1\|1447095_1447359_-	PspC domain-containing protein	NA	NA	NA	NA
WP_084871435.1\|1447424_1447865_-	SprT family protein	NA	NA	NA	NA
WP_084871436.1\|1447851_1449984_-	RNA-binding transcriptional accessory protein	NA	NA	NA	NA
WP_049528653.1\|1450288_1451191_+	permease	NA	NA	NA	NA
WP_084871437.1\|1451190_1452006_+	TIGR03943 family protein	NA	NA	NA	NA
WP_049528648.1\|1452675_1453728_-	hypothetical protein	NA	NA	NA	NA
WP_002946754.1\|1453724_1454048_-	CRISPR-associated endonuclease Cas2	NA	NA	NA	NA
WP_111686630.1\|1454049_1454961_-	type II CRISPR-associated endonuclease Cas1	NA	NA	NA	NA
WP_084871438.1\|1455137_1458557_-	type II CRISPR RNA-guided endonuclease Cas9	NA	NA	NA	NA
WP_004182385.1\|1458742_1459678_+\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	4.0e-86	54.0
WP_084871439.1\|1459764_1461426_-	STAS domain-containing protein	NA	NA	NA	NA
WP_061652218.1\|1461673_1462288_-	hypothetical protein	NA	NA	NA	NA
WP_013990847.1\|1462383_1463025_-	lipase	NA	NA	NA	NA
WP_084871440.1\|1463051_1463663_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_5

1513181 : 1522554

Streptococcus_phage(100.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_070850334.1\|1513181_1513859_-	type I 3-dehydroquinate dehydratase	W6LP76	Streptococcus_phage	2.4e-112	91.6
WP_013990894.1\|1513855_1515019_-	class I SAM-dependent rRNA methyltransferase	W6LLI2	Streptococcus_phage	1.5e-210	94.3
WP_013990895.1\|1515180_1517367_+	LTA synthase family protein	W6LM83	Streptococcus_phage	0.0e+00	95.0
WP_111686636.1\|1517370_1518840_-\|transposase	IS1182 family transposase	A0A1X9I5T2	Streptococcus_phage	1.3e-208	76.8
WP_002886071.1\|1519103_1519289_+	hypothetical protein	W6LMT3	Streptococcus_phage	1.9e-24	93.4
WP_002886048.1\|1519442_1520747_-	phosphopyruvate hydratase	W6LP63	Streptococcus_phage	1.4e-246	99.5
WP_049528980.1\|1520952_1521408_+	YueI family protein	W6LLD2	Streptococcus_phage	5.0e-66	82.8
WP_049528977.1\|1521438_1522554_-	glycerate kinase	W6LM47	Streptococcus_phage	1.9e-135	85.2

DBSCAN-SWA_6

1688674 : 1694976

Streptococcus_phage(83.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004183081.1\|1688674_1689028_-	arsenate reductase family protein	M1PLC0	Streptococcus_phage	1.3e-40	67.5
WP_013991010.1\|1689062_1689557_-	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	6.9e-37	46.3
WP_045768721.1\|1689612_1690791_-	phosphoglycerate dehydrogenase	M1NSB9	Streptococcus_phage	1.0e-179	80.1
WP_045768722.1\|1690809_1691367_-	GNAT family N-acetyltransferase	M1PSC3	Streptococcus_phage	1.2e-56	60.1
WP_111686654.1\|1691379_1692474_-	3-phosphoserine/phosphohydroxythreonine transaminase	M1Q1P2	Streptococcus_phage	2.8e-171	80.7
WP_045768724.1\|1692628_1693522_-	ROK family protein	NA	NA	NA	NA
WP_004183092.1\|1693637_1694033_+	lactoylglutathione lyase	NA	NA	NA	NA
WP_004183097.1\|1694076_1694976_-	SPFH domain-containing protein	A0A1V0SL90	Klosneuvirus	1.8e-35	32.8

DBSCAN-SWA_7

1803721 : 1862188

Bacillus_virus(14.29%)

tRNA,protease,transposase,bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003018306.1\|1803721_1805164_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	NA	NA	NA	NA
WP_014632690.1\|1805163_1806630_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	NA	NA	NA	NA
WP_002884769.1\|1806629_1806932_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	NA	NA	NA	NA
WP_049553869.1\|1807532_1808972_-	6-phospho-beta-glucosidase	NA	NA	NA	NA
WP_014632687.1\|1809128_1809680_-	cysteine hydrolase	G3MA16	Bacillus_virus	3.4e-24	40.3
WP_002884784.1\|1809746_1810532_-	GTP-sensing pleiotropic transcriptional regulator CodY	NA	NA	NA	NA
WP_014632686.1\|1810798_1812013_-	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_002891687.1\|1812372_1812825_+	universal stress protein	NA	NA	NA	NA
WP_014632685.1\|1812906_1813659_-	hypothetical protein	NA	NA	NA	NA
WP_014632684.1\|1813728_1814529_-	pyruvate formate lyase-activating protein	A0A2P0VNQ0	Tetraselmis_virus	2.9e-24	31.8
WP_014632683.1\|1814715_1815438_-	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_014632682.1\|1815791_1817123_-	HlyC/CorC family transporter	NA	NA	NA	NA
WP_014632681.1\|1817233_1818016_+	ABC transporter ATP-binding protein	A0A2K9L0W2	Tupanvirus	1.7e-08	25.6
WP_049529032.1\|1818199_1820266_-	sodium:proton antiporter	NA	NA	NA	NA
WP_002891697.1\|1820274_1820517_-	hypothetical protein	NA	NA	NA	NA
WP_049529030.1\|1820513_1821062_-	SAM-dependent methyltransferase	A0A2H4PQV0	Staphylococcus_phage	2.4e-38	44.6
WP_014632678.1\|1821058_1822003_-	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	1.2e-34	46.2
WP_002884703.1\|1822086_1823163_-	PDZ domain-containing protein	NA	NA	NA	NA
WP_014632676.1\|1823140_1823638_-	pantetheine-phosphate adenylyltransferase	A0A1B1IVQ3	uncultured_Mediterranean_phage	2.2e-14	30.1
WP_079119907.1\|1823670_1824234_-	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	NA	NA	NA	NA
WP_014632674.1\|1824358_1825279_-	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	2.7e-87	52.3
WP_002884393.1\|1825344_1825569_-	DUF4059 family protein	NA	NA	NA	NA
WP_014632672.1\|1825780_1826524_-	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.2e-29	40.1
WP_096832659.1\|1826523_1827270_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_004183337.1\|1827866_1828697_-	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_004183338.1\|1828911_1829802_-	hypothetical protein	NA	NA	NA	NA
WP_045769047.1\|1829902_1831012_-	DNA polymerase IV	NA	NA	NA	NA
WP_084871004.1\|1831279_1833592_+	formate C-acetyltransferase	A0A2P0VNR5	Tetraselmis_virus	1.1e-113	32.4
WP_004183341.1\|1833750_1833888_+	hypothetical protein	NA	NA	NA	NA
WP_084871005.1\|1833902_1835597_+	oleate hydratase	NA	NA	NA	NA
WP_084871006.1\|1835884_1836667_+	carbonic anhydrase family protein	NA	NA	NA	NA
WP_049529020.1\|1836752_1837205_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_070850120.1\|1837221_1837896_-	hypothetical protein	NA	NA	NA	NA
WP_014632661.1\|1837879_1838827_-	serine hydrolase	A0A1D8EXR7	Mycobacterium_phage	1.2e-05	25.1
WP_004183351.1\|1838826_1839582_-	peptidase	NA	NA	NA	NA
WP_045001459.1\|1839755_1840427_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_014632658.1\|1840514_1841381_-	aquaporin family protein	M1HJ77	Paramecium_bursaria_Chlorella_virus	2.6e-18	28.4
WP_084871007.1\|1841504_1843772_+	Xaa-Pro dipeptidyl-peptidase	NA	NA	NA	NA
WP_111686662.1\|1844357_1844648_-	hypothetical protein	NA	NA	NA	NA
WP_021152512.1\|1844939_1845236_-\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA
WP_049553855.1\|1848787_1848976_-	hypothetical protein	NA	NA	NA	NA
WP_049553854.1\|1848988_1849222_-\|bacteriocin	ComC/BlpC family leader-containing pheromone/bacteriocin	NA	NA	NA	NA
WP_049527516.1\|1849365_1849533_-	hypothetical protein	NA	NA	NA	NA
WP_049553910.1\|1849548_1849728_-\|bacteriocin	ComC/BlpC family leader-containing pheromone/bacteriocin	NA	NA	NA	NA
WP_111686663.1\|1849887_1851633_-	ABC transporter ATP-binding protein	F2Y1V6	Organic_Lake_phycodnavirus	3.3e-17	26.8
WP_014632650.1\|1851625_1853383_-	ATP-binding cassette domain-containing protein	W8CYL7	Bacillus_phage	1.0e-45	28.2
WP_080936871.1\|1853446_1853791_-	hypothetical protein	NA	NA	NA	NA
WP_049553913.1\|1853995_1854523_-	VanZ family protein	NA	NA	NA	NA
WP_096832658.1\|1854524_1855634_-	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	NA	NA	NA	NA
WP_084871014.1\|1855697_1856420_-	DUF1027 domain-containing protein	NA	NA	NA	NA
WP_084871015.1\|1856474_1857830_-	metallophosphoesterase	NA	NA	NA	NA
WP_004183378.1\|1858112_1858349_-\|bacteriocin	ComC/BlpC family leader-containing pheromone/bacteriocin	NA	NA	NA	NA
WP_004183380.1\|1858489_1859743_-	GHKL domain-containing protein	NA	NA	NA	NA
WP_004183381.1\|1859739_1860468_-	response regulator transcription factor	NA	NA	NA	NA
WP_171021848.1\|1861168_1862188_+\|transposase	IS30-like element IS1139 family transposase	A0A2K9V2S9	Faecalibacterium_phage	7.1e-36	34.9

DBSCAN-SWA_8

1979161 : 2031957

Streptococcus_phage(37.5%)

tRNA,protease,transposase,bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_111686669.1\|1979161_1980622_+\|transposase	IS1182 family transposase	A0A1X9I5T2	Streptococcus_phage	3.6e-206	76.1
WP_013991218.1\|1980634_1981048_-	acyl-CoA thioesterase	NA	NA	NA	NA
WP_049527782.1\|1981065_1981401_-	conjugal transfer protein TraF	NA	NA	NA	NA
WP_002885761.1\|1986925_1988068_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	9.3e-85	42.8
WP_002885866.1\|1988274_1988409_-	50S ribosomal protein L34	NA	NA	NA	NA
WP_111686670.1\|1988604_1989168_-	NAD(P)H-dependent oxidoreductase	NA	NA	NA	NA
WP_021144658.1\|1989164_1989761_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_021144659.1\|1989892_1990936_-	protein jag	NA	NA	NA	NA
WP_037605452.1\|1990947_1991754_-	membrane protein insertase YidC	NA	NA	NA	NA
WP_002891957.1\|1991869_1992205_-	ribonuclease P protein component	NA	NA	NA	NA
WP_037601513.1\|1992289_1993675_-	argininosuccinate lyase	NA	NA	NA	NA
WP_002885646.1\|1994001_1995201_-	argininosuccinate synthase	NA	NA	NA	NA
WP_002886967.1\|1997225_1997969_-	response regulator transcription factor	NA	NA	NA	NA
WP_049529280.1\|1997970_1999287_-	GHKL domain-containing protein	NA	NA	NA	NA
WP_111686671.1\|1999310_2000591_-	hypothetical protein	NA	NA	NA	NA
WP_045771785.1\|2000612_2001503_-	hypothetical protein	NA	NA	NA	NA
WP_014632564.1\|2001557_2002865_-	GHKL domain-containing protein	NA	NA	NA	NA
WP_013991233.1\|2003317_2004772_-\|tRNA	glutamate--tRNA ligase	NA	NA	NA	NA
WP_013991234.1\|2005007_2006978_-	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_002885800.1\|2007159_2007849_-	50S ribosomal protein L1	NA	NA	NA	NA
WP_002885648.1\|2007948_2008374_-	50S ribosomal protein L11	NA	NA	NA	NA
WP_002885872.1\|2008545_2008899_+	DUF3397 domain-containing protein	NA	NA	NA	NA
WP_002886981.1\|2008993_2009491_-	carbonic anhydrase	NA	NA	NA	NA
WP_111686672.1\|2009641_2010337_-	TIGR00266 family protein	NA	NA	NA	NA
WP_080562498.1\|2010413_2011775_-	DNA repair protein RadA	NA	NA	NA	NA
WP_002886984.1\|2011771_2012239_-	cysteine hydrolase	NA	NA	NA	NA
WP_111686673.1\|2012248_2012695_-	dUTP diphosphatase	Q332E8	Clostridium_botulinum_C_phage	2.5e-33	50.7
WP_002886986.1\|2012902_2013505_+	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	1.8e-55	54.2
WP_002885631.1\|2013523_2014774_+	NAD(P)H-dependent oxidoreductase	A0A2P0ZL82	Lactobacillus_phage	7.6e-56	52.7
WP_014635096.1\|2014890_2015682_+	formate/nitrite transporter family protein	NA	NA	NA	NA
WP_002886989.1\|2015690_2016257_+	MptD family putative ECF transporter S component	NA	NA	NA	NA
WP_002886991.1\|2016371_2017394_+	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_002886993.1\|2017410_2018325_+	UTP--glucose-1-phosphate uridylyltransferase GalU	A0A127AW70	Bacillus_phage	2.8e-76	51.9
WP_014632558.1\|2018370_2019045_-\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_002886996.1\|2019035_2019563_-	5-formyltetrahydrofolate cyclo-ligase	NA	NA	NA	NA
WP_002886997.1\|2019631_2020765_-	N-acetyldiaminopimelate deacetylase	NA	NA	NA	NA
WP_002886999.1\|2020842_2021541_-	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase	NA	NA	NA	NA
WP_002887000.1\|2021626_2022379_-	HAD family hydrolase	NA	NA	NA	NA
WP_002887001.1\|2022492_2023332_-	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_002885650.1\|2023752_2023911_+\|bacteriocin	class IIb bacteriocin, lactobin A/cerein 7B family	NA	NA	NA	NA
WP_002887002.1\|2023930_2024098_+\|bacteriocin	class IIb bacteriocin, lactobin A/cerein 7B family	NA	NA	NA	NA
WP_045001373.1\|2024145_2024400_+	hypothetical protein	NA	NA	NA	NA
WP_014632555.1\|2024485_2025004_-	nucleoside deaminase	NA	NA	NA	NA
WP_014632554.1\|2025773_2026166_-	single-stranded DNA-binding protein	A1EAD1	Streptococcus_phage	7.5e-26	47.0
WP_045001371.1\|2026593_2027271_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_002885779.1\|2027536_2028160_-\|tRNA	DUF4479 and tRNA-binding domain-containing protein	NA	NA	NA	NA
WP_014632552.1\|2028191_2028716_-	hypothetical protein	NA	NA	NA	NA
WP_002885723.1\|2028719_2029034_-	thioredoxin family protein	NA	NA	NA	NA
WP_002885838.1\|2029030_2029315_-	DUF4651 domain-containing protein	NA	NA	NA	NA
WP_014632550.1\|2029414_2030482_+	glutamyl aminopeptidase	NA	NA	NA	NA
WP_002885846.1\|2030497_2031268_+	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	5.6e-33	36.1
WP_111686674.1\|2031294_2031957_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_9

2162266 : 2173700

Staphylococcus_phage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014632484.1\|2162266_2162965_-	transglycosylase SLT domain-containing protein	Q4Z8Z7	Staphylococcus_phage	2.1e-26	68.8
WP_014632483.1\|2163148_2163730_-	LysM peptidoglycan-binding domain-containing protein	A0A249XZV3	Enterococcus_phage	4.6e-24	54.1
WP_045001313.1\|2164030_2164825_-	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
WP_045772057.1\|2164817_2165660_-	energy-coupling factor transporter ATPase	A0A2H4PQG7	Staphylococcus_phage	1.8e-13	27.9
WP_002885731.1\|2165635_2166466_-	energy-coupling factor transporter ATPase	G9BWD6	Planktothrix_phage	1.8e-21	32.7
WP_002885640.1\|2166478_2167021_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
WP_111686685.1\|2167033_2167891_-	DUF4115 domain-containing protein	NA	NA	NA	NA
WP_014632479.1\|2167949_2169227_-	insulinase family protein	A0A2H4UVM3	Bodo_saltans_virus	1.3e-05	28.7
WP_013991338.1\|2169228_2170479_-	insulinase family protein	A0A1X9I714	Streptococcus_phage	2.5e-91	39.9
WP_013991339.1\|2170556_2170934_+	S4 domain-containing protein YaaA	A0A1X9I5V8	Streptococcus_phage	2.0e-23	71.1
WP_013991340.1\|2170936_2172037_+	DNA replication/repair protein RecF	NA	NA	NA	NA
WP_013991341.1\|2172218_2173700_-	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	2.6e-95	40.3

Anti-CRISPR protein detection

Acr_ID: NZ_LS483366.1|WP_111686603.1|1265618_1266170_-|anti-CRISPR-protein-AcrIIA6

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Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_LS483366.1|WP_111686603.1|1265618_1266170_-|anti-CRISPR-protein-AcrIIA6

1265618_1266170_-

183 aa aa

hit_Aca_id	identity	query_coverage	hit_coverage
gnl\|BL_ORD_ID\|42	0.825136612021858	1	1.0

1218112-1279126

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_LS483366

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

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