CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_LS483369	Neisseria cinerea strain NCTC10294 chromosome 1	1 crisprs	cas2,cas1,cas9,cas3,DEDDh,DinG	0	5	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_LS483369_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LS483369_1

106122-106619

TypeII

Consensus_repeat	Method
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT	PILER-CR
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT	CRISPRCasFinder
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT	CRT

7 spacers

cas2,cas1,cas9

The CRISPR arrays of NZ_LS483369_1

>merge|NZ_LS483369|1|106122-106619|PILER-CR,CRISPRCasFinder,CRT
GTTGTAGCTCCCATTCTCATTTTGCAGTGCTACAATGTACCGGAGCCGCGTTTGCCGACACGGATAGTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAATACTTTCTAATTTACAACGCCTCCACCTATTGTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAATAATAATGACATCGCGTTTAATCTCTTCTTCGTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAATCCGCATGGTCGAATGGAATGCATGCGGAGAGTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAATGGCGTGAACGGTGCTGATAAGGCTGTTGCAGTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAATATTGTTTTAATTGCCTTTAAAAGGACGATAGTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAATTTCTATCTCTTGGGGTGTGAAGTGTTGTCCGTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT

>NZ_LS483369|1|1|106122-106619|PILER-CR
GTTGTAGCTCCCATTCTCATTTTGCAGTGCTACAAT	GTACCGGAGCCGCGTTTGCCGACACGGATA
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT	ACTTTCTAATTTACAACGCCTCCACCTATT
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT	AATAATGACATCGCGTTTAATCTCTTCTTC
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT	CCGCATGGTCGAATGGAATGCATGCGGAGA
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT	GGCGTGAACGGTGCTGATAAGGCTGTTGCA
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT	ATTGTTTTAATTGCCTTTAAAAGGACGATA
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT	TTCTATCTCTTGGGGTGTGAAGTGTTGTCC
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT

>NZ_LS483369|1|1|106122-106619|CRISPRCasFinder
GTTGTAGCTCCCATTCTCATTTTGCAGTGCTACAAT	GTACCGGAGCCGCGTTTGCCGACACGGATA
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT	ACTTTCTAATTTACAACGCCTCCACCTATT
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT	AATAATGACATCGCGTTTAATCTCTTCTTC
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT	CCGCATGGTCGAATGGAATGCATGCGGAGA
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT	GGCGTGAACGGTGCTGATAAGGCTGTTGCA
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT	ATTGTTTTAATTGCCTTTAAAAGGACGATA
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT	TTCTATCTCTTGGGGTGTGAAGTGTTGTCC
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT

>NZ_LS483369|1|1|106122-106619|CRT
GTTGTAGCTCCCATTCTCATTTTGCAGTGCTACAAT	GTACCGGAGCCGCGTTTGCCGACACGGATA
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT	ACTTTCTAATTTACAACGCCTCCACCTATT
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT	AATAATGACATCGCGTTTAATCTCTTCTTC
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT	CCGCATGGTCGAATGGAATGCATGCGGAGA
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT	GGCGTGAACGGTGCTGATAAGGCTGTTGCA
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT	ATTGTTTTAATTGCCTTTAAAAGGACGATA
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT	TTCTATCTCTTGGGGTGTGAAGTGTTGTCC
GTTGTAGCTCCCTTTCTCATTTCGCAGTGCTACAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LS483369.1\|WP_111726270.1\|101881_102541_-\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|319835
NZ_LS483369.1\|WP_167395505.1\|102700_104815_+\|TonB-dependent-siderophore-receptor	unknown	unknown	gnl\|CDD\|227114
NZ_LS483369.1\|WP_111726279.1\|107981_111227_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	COG3513_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226044
NZ_LS483369.1\|WP_111726262.1\|96180_97101_+\|bifunctional-riboflavin-kinase/FAD-synthetase	unknown	unknown	gnl\|CDD\|235536
NZ_LS483369.1\|WP_107859435.1\|95705_96080_+\|hypothetical-protein	unknown	unknown	unknown
NZ_LS483369.1\|WP_002214566.1\|106682_107009_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NZ_LS483369.1\|WP_111726284.1\|120442_121618_-\|DegT/DnrJ/EryC1/StrS-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223476
NZ_LS483369.1\|WP_080549666.1\|115698_115935_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|225303
NZ_LS483369.1\|WP_002240002.1\|115912_116116_+\|hypothetical-protein	unknown	unknown	unknown
NZ_LS483369.1\|WP_111726283.1\|118484_120395_-\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|224011
NZ_LS483369.1\|WP_111726260.1\|93944_94622_-\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|182507
NZ_LS483369.1\|WP_003676444.1\|94696_95578_-\|DUF1275-domain-containing-protein	unknown	unknown	gnl\|CDD\|377734
NZ_LS483369.1\|WP_111726281.1\|117136_118429_-\|valine--pyruvate-transaminase	unknown	unknown	gnl\|CDD\|226485
NZ_LS483369.1\|WP_167395506.1\|105002_105812_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|225375
NZ_LS483369.1\|WP_003676429.1\|100826_101795_+\|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase	unknown	unknown	gnl\|CDD\|234893
NZ_LS483369.1\|WP_101119092.1\|116247_117084_+\|PHP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223686
NZ_LS483369.1\|WP_111726277.1\|107001_107916_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|274694
NZ_LS483369.1\|WP_111727596.1\|111505_114940_-\|DNA-polymerase-III-subunit-alpha	unknown	unknown	gnl\|CDD\|235554
NZ_LS483369.1\|WP_111726268.1\|100302_100797_+\|lipoprotein-signal-peptidase	unknown	unknown	gnl\|CDD\|234739
NZ_LS483369.1\|WP_111726264.1\|97242_100032_+\|isoleucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235588

Protein	Function_ID	Function_description	E-value
NZ_LS483369.1\|WP_111726270.1\|101881_102541_-\|HAD-IA-family-hydrolase	gnl\|CDD\|319835	cd07533, HAD_like, uncharacterized family of the haloacid dehalogenase-like (HAD) hydrolase superfamily, similar to Parvibaculum lavamentivorans HAD-superfamily hydrolase, subfamily IA, variant 1. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.06414e-93
NZ_LS483369.1\|WP_167395505.1\|102700_104815_+\|TonB-dependent-siderophore-receptor	gnl\|CDD\|227114	COG4773, FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism].	0
NZ_LS483369.1\|WP_111726279.1\|107981_111227_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|226044	COG3513, COG3513, Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms].	0
NZ_LS483369.1\|WP_111726262.1\|96180_97101_+\|bifunctional-riboflavin-kinase/FAD-synthetase	gnl\|CDD\|235536	PRK05627, PRK05627, bifunctional riboflavin kinase/FAD synthetase.	5.61985e-131
NZ_LS483369.1\|WP_167395506.1\|105002_105812_+\|alpha/beta-hydrolase	gnl\|CDD\|225375	COG2819, COG2819, Predicted hydrolase of the alpha/beta superfamily [General function prediction only].	8.71074e-92
NZ_LS483369.1\|WP_002214566.1\|106682_107009_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	1.33449e-61
NZ_LS483369.1\|WP_111726284.1\|120442_121618_-\|DegT/DnrJ/EryC1/StrS-aminotransferase-family-protein	gnl\|CDD\|223476	COG0399, WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane].	1.71505e-159
NZ_LS483369.1\|WP_080549666.1\|115698_115935_+\|RNA-binding-protein	gnl\|CDD\|225303	COG2501, COG2501, S4-like RNA binding protein [Replication, recombination, and repair].	7.39284e-29
NZ_LS483369.1\|WP_111726283.1\|118484_120395_-\|polysaccharide-biosynthesis-protein	gnl\|CDD\|224011	COG1086, COG1086, Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	0
NZ_LS483369.1\|WP_111726260.1\|93944_94622_-\|OmpA-family-protein	gnl\|CDD\|182507	PRK10510, PRK10510, OmpA family lipoprotein.	3.85622e-51
NZ_LS483369.1\|WP_003676444.1\|94696_95578_-\|DUF1275-domain-containing-protein	gnl\|CDD\|377734	pfam06912, DUF1275, Protein of unknown function (DUF1275). This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown although most members have 6 TM regions, and may be putative permeases.	1.41427e-31
NZ_LS483369.1\|WP_111726281.1\|117136_118429_-\|valine--pyruvate-transaminase	gnl\|CDD\|226485	COG3977, COG3977, Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase [Amino acid transport and metabolism].	0
NZ_LS483369.1\|WP_111726277.1\|107001_107916_-\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274694	TIGR03639, cas1_NMENI, CRISPR-associated endonuclease Cas1, subtype II/NMENI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.	3.62751e-140
NZ_LS483369.1\|WP_003676429.1\|100826_101795_+\|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase	gnl\|CDD\|234893	PRK01045, ispH, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed.	0
NZ_LS483369.1\|WP_101119092.1\|116247_117084_+\|PHP-domain-containing-protein	gnl\|CDD\|223686	COG0613, COG0613, Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only].	9.83026e-85
NZ_LS483369.1\|WP_111727596.1\|111505_114940_-\|DNA-polymerase-III-subunit-alpha	gnl\|CDD\|235554	PRK05673, dnaE, DNA polymerase III subunit alpha; Validated.	0
NZ_LS483369.1\|WP_111726268.1\|100302_100797_+\|lipoprotein-signal-peptidase	gnl\|CDD\|234739	PRK00376, lspA, lipoprotein signal peptidase.	8.40745e-62
NZ_LS483369.1\|WP_111726264.1\|97242_100032_+\|isoleucine--tRNA-ligase	gnl\|CDD\|235588	PRK05743, ileS, isoleucyl-tRNA synthetase; Reviewed.	0

>NZ_LS483369.1|WP_167395506.1|105002_105812_+|alpha/beta-hydrolase
MKTTYTTQAARLPQAFETEISSAGTGRTYRIQTAAIGEMPPEGYPVLFVLDGEAFFPALFNIMQSLMNNPVTRSRAPCLIVGVGYAGGGVRDLAQRAADYTPPLRSNASEDEQRQFGQADRFAEFIDSELTAFLESKYRLDKNETAVFGHSFGALFGLYSLLSHRRFRRHWLVSPSIWWHNRRILDFMPSENRLNGIDVCLNIGALERRSDCKRREERDMAGLSERMVAELDKHGAAVFFREYPNANHGNVPFHSLTDCVEYLRKAWQR
>NZ_LS483369.1|WP_167395505.1|102700_104815_+|TonB-dependent-siderophore-receptor
MSVFRINMTAAAVLTVLSSSAFAAQTEGLETVHIKGQRSYNAIATEKNGDYSSFAATVGTKIPASLREIPQSVSIITNQQVKDRNVDTFDQLARKTPGLRVLSNDDGRSSVYARGYEYSEYNIDGLPAQMQSINGTLPNLFAFDRVEVMRGPSGLFDSSGEMGGIVNLVRKRPTKAFQGHAAAGFGTHKQYKAEADVSGSLNADGSVRGRVMAQTVGASPRPAEKNNHHETFYAAADWDINPDTVLGAGYLYQQRHLAPYNGLPADADGKLPSLPQHAFVGADWNKFKMHSHDVFADLKHYFGNGGYGKVGMRYSDRKADSNYTFAGSSLDKAGKAAAAGLGTDIKQKAFAVDASYSRPFALGNTANEFVIGADYNRFRSTNEQGRSTLSKSVALDGFRALPYNGILQNARAGNKGFNHSVTEENLDETGLYAKTVFRPLEGLSLIAGGRVGHHKIESGDGKTLHKASKTKFTSYAGAVYDIDGSNSLYASASQLYTPQTNLDADGKLLKPRQGNQFEVGYKGSHMDDRLNTRVSFYRMKDKNAAAPLNPKDRNTRYAALGERVMEGVETEISGAITPKWQIHAGYSYLHSQIKTASNSRDDGIFLLMPKHSANLWTTYQVTPELTIGGGVNAMSGITSSAGMHAGGYATFDAMAAYRFTPKLKLQVNADNISNRRYYARVGGTNTFNIPGSERSLTANLRYSF
>NZ_LS483369.1|WP_111726270.1|101881_102541_-|HAD-IA-family-hydrolase
MTPPKLIIFDWDGTLADTTQPIIDTMRRSFAECGFPMPETDRVRSLIGYSLPEIIRDLLEMPSETAVADIARTYSAHYLNPNNRNMSLFPQALPCLDKLKAQGYWLAVATGKGRAGLDNAISQTATGGYWLATACAGEYPSKPSPEMVFGLCGELGLDPKEALVVGDTAHDLHMAANAGAAAVGVATGAHSREQLLSAPHLAVLDDLSELPGFLAQHYA
>NZ_LS483369.1|WP_003676429.1|100826_101795_+|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase
MNGKTIILANPRGFCAGVDRAISIVERALEEFGAPIYVRHEVVHNKFVVDNLREKGAVFVDDLAEVPQGATLIYSAHGVSKAVQQEAAERGFRVFDATCPLVTKVHKEVARLDALDCEIIMIGHKGHVEVEGTMGQLEPGKMLLVETVGDVAKLEVKNPDKLAYVSQTTLSVDETKDIIAALNARFPNIRNPRKEDICYATTNRQTAVKELAEQCDIVIVVGSPNSSNSNRLREVAALRGIDAYMVDNAGYLQRAWFEGKHKVGVTAGASAPEVLVQEVLATIRGWGHETVREGEGAEESIVFVLPKELRREGETKPDLCKR
>NZ_LS483369.1|WP_111726268.1|100302_100797_+|lipoprotein-signal-peptidase
MSSSVSSKTRYWVLALAAIVLDQWSKWAVLSSFQYQERVNVIPSFFDLTLVYNPGAAFSFLADQGGWQKYFFLLLAVAVSIYLVRAILRDEFAALGKTGAAMIIGGALGNVIDRLIHGHVVDFLLFYWQDWFYPAFNIADSFICVGAVLAVLDNIVHRTDSKKT
>NZ_LS483369.1|WP_111726264.1|97242_100032_+|isoleucine--tRNA-ligase
MTDYSKTVNLLESPFPMRGNLAKREPAWLKSWYEQKRYQKLREIAKGRPKFILHDGPPYANGDIHIGHAVNKILKDIIIRSKTQAGFDAPYVPGWDCHGLPIEVMVEKLHGKDMPKARFRELCREYAAEQIARQKKDFIRLGVLGDWDNPYLTMDFKTEADTVRMLGEIYKSGYLYRGAKPVQFCLDCGSSLAEAEVEYKDKVSPAIDVGYPFKDTAALAAAFGLAGIEGKAFAVIWTTTPWTLPASQAVSAGADVVYQLIDTPKGKLVLAKDLAEDALKRYGFSDGIAILAETTGDKLENLHMNHPFLERDIPMLNGDHVTTDAGTGLVHTAPAHGLEDYTVCNKYGIELYNPVNAEGKYISETPRVAGMRVWEANPVILQWLEETGNLLASSKIEHSYAHCWRHKTPLIYRATGQWFVGMDKAGADGKTLRDKAIKAVDDTEFFPSWGRARLEAMIEGRPDWVVSRQRYWGTPMTFFVHKETGELHPNSAELLEKVAQRIEEKGIEAWFSLDKSELLSAEDCENYDKLSDTMDVWFDSGSTHYSVLKQREELDWPADLYLEGSDQHRGWFQSSMLTGCASSMGRAPYKQLLTHGFVVDQNGRKMSKSIGNVVAPQEVYNEFGADILRLWAASTDYSGELAISKEILKRVTESYRRIRNTLSFLFANLSDFDPFEHTVPQADMVEIDRYALVLARQLQERLAGDFYPRYAFHFAVKDIVAFCSEDLGAFYLDILKDRLYTTQADSHARRSAQTALYHITRSLVLLIAPILCFTGEEAWDIIGGGEEDSVLFHTWHEFPTINEKAEAELVKKWTAIREAREAVTAAIEPLRADKTVGSSLQAEAEITAPEEIADYLNALGEELRFALLVSKAEVKVGDELAVAAKASDGEKCERCWHYTHDVGAVAGYETVCKRCAGNVGGEGETRHYA
>NZ_LS483369.1|WP_111726262.1|96180_97101_+|bifunctional-riboflavin-kinase/FAD-synthetase
MRIRLGRHDAPDFPQGAAVTIGNFDGVHLGHKHILQKLRLEADTRGLPVVAVVFEPQPKEFFALRTGRMPPCRISPLRTKLELLEGTGCVDAVWVLRFDQNFSEISAQGFIDHLLRQTLNTRYLLVGDDFRFGAGREGCFELLAQQPDMQTERTPSVIVEDIRTSSTAVRQALSDGNLAYAKKLLGHDYVLGGRVVHGRKLGRTLNAPTANIRLPGHRYALGGVFVVEADGAFGTRRGVASFGFNPTVDSGCSQKLEVHLFDFQGDLYGQRLNVRFLHKLRDEEKFDGMEELKRQIEADMEAAKCW
>NZ_LS483369.1|WP_107859435.1|95705_96080_+|hypothetical-protein
MRRYIAAAAAILILTACATPEQQAAYRQAQQRYEQDLQVALAAQCDREAAQLIRRQFDSGYAPMPDAERQIFKTRYTEKLSDPMFQACYKMAWQNYISQQQLKEVRLSRYYDDWGYPFYRPWWW
>NZ_LS483369.1|WP_003676444.1|94696_95578_-|DUF1275-domain-containing-protein
MNESDRHAKHARRSRHHIPPFWQADRPYLHEHHISDARFRRLGYIMSLLAGAINAGGFFAFARYTSHVTGSMSLLADMVYLKQWTAAAVAMVSVLCFIAGAAHSGWVILWTQQMRFRGSYGLSMWLEALYLLIFGLFGITALQWDADGGLVFPSLALFLLCFIMGMHNTVMTLLSGGAIRSTHMTGTATDLGIEISRALYYSKTHHPRLPHVRVNKPKMWLLSGMMQAFLLGGIIGAWGYHKIGHHFALPVSAVLLILGAGSVGYDVKVRFLWIWRKFRRKYRQTGVVSGKIG
>NZ_LS483369.1|WP_111726260.1|93944_94622_-|OmpA-family-protein
MTFFKPFTVVLTASALALSGCVTDPSTVRQSADKTALYGLGGAAVCGIMGALTHGGKGARNSALVCGALGAGIGGYMDYQEQRLRQSLAGTQVQVQRQGNQIKLVMPENVTFATGSAVLSDNAQFALNTAAQTLVQYPDTTLTINGHTDNTGSDAINNPLSQHRAQTVAYYLQSRGVAASRLAVYGYGSHMPAASNATAEGRAQNRRVEILINPDQRAVNAAQQM
>NZ_LS483369.1|WP_002214566.1|106682_107009_-|CRISPR-associated-endonuclease-Cas2
MSEAKFMRIIVFFDLPVITAAKRKAANQFRQFLLKDGYQMLQLSVYSRIVKGRDSLQKHHNRLCANLPQEGSIRCLEITEKQYAAMKLLLGELKTQEKKVNSDQLLLF
>NZ_LS483369.1|WP_111726277.1|107001_107916_-|type-II-CRISPR-associated-endonuclease-Cas1
MTWRSLLIQNGGKLSLQRRQLLIQQNGESHTVPLEDIAVIIIENRETLITAPLLSALAEHGATLLTCDEQFLPCGQWLPYAQYHRQLKILKLQLNISEPLKKQLWQHIVRQKILNQAFVADETGNDLAAKRLRTLASEVRSGDTGNREAQAAALYFQALFGEKFTRNDNNAVNAALNYTYAVLRAAVARALTLYGWLPALGLFHRSELNPFNLADDFIEPLRPLADLTVIHLYEQGRLKTELTPGIKQHLIKTLHYQISIERQHFSTLAAIDKMVSSFQAGVTDKNAKQLKLPEILPLKEYQYE
>NZ_LS483369.1|WP_111726279.1|107981_111227_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MAAFKPNPINYILGLDIGIASVGWAMVEIDEAENPIRLIDLGVRVFERAEVPKTGDSLAMARRLARSVRRLTRRRAHRLLRARRLLKREGILQAADFDENGLIKSLPNTPWQLRAAALDRKLMPLEWSAVLLHLIKHRGYLSQRKNEGETADKELGALLKGVADNAHTLQTGDFRTPAELALNKFEKESGHIRNQRGDYSHTFSRKDLQAELNLLFEKQKEFGNPHVSDGLKEGIETLLMTQRPALSGDAVQKMLGHCTFEPAEPKAAKNTYTAERFVWLTKLNNLRILEQGSERPLTDTERATLMDEPYRKSKLTYAQARKLLDLDDTAFFKGLRYGKDNAEASTLMEMKAYHAISRALEKEGLKDKKSPLSLSPELQDEIGTAFSLFKTDEDITGRLKDRVQPEILEALLKHINFDEFVQISLKALRRIVPLMEQGKRYDEACTEIYGDHYGKKNTEEEIYLPPIPADEIRNPVVLRALSQARKVINAVVRRYGSPARIHIETAREVGKSFKDRKEIEKRQEENRKDREKAAAKFREYFPNFVDEPKSKDILKLRLYEQQHGKCLYSGKEINLGRLNEKGYVEIDHALPFSRTWDDSFNNKVLVLGSENQNKSNQTPYEYFNGKDNSREWQKFKARVETSRFPRSKKQRILLQKFDEDGFKERNLNDTRYVNRFLCQFVADHMRLTGKGKRRVFASNGQITNLLRGFWGLRKVRAENDRHHALDAVVVACSTVAMQQKITRFVRYKEMNAFDGKTIDKETGEVLHQKAHFPQPWEFFAQEVMIRVFGKPDGKPEFEEADTPEKLRALLAEKLSSRPEAVHEYVTPLFVSRAPNRKMSGQGHMETVKSAKRLDEGISVLRVPLTQLKLKDLEKMVNREREPKLYEALKARLEAHKDDPAKAFAEPFYKYDKAGNRTQQVKAVRVEQVQKTGVWVRNHNGIADNATMVRVDVFEKGGKYYLVPIYSWQVAKGILPDRAVVAYADEENWTVIDESFRFKFVLYSNDLIKVRLKKDSFLGYFSGLDRATGAISLREHDMEKSKGKDGIYRIGVKTALSFQKYQIDELGKEIRPCRLKKRPPVR
>NZ_LS483369.1|WP_111727596.1|111505_114940_-|DNA-polymerase-III-subunit-alpha
MTEPTYIPLRLHTEFSITDGMVRIKKLIAKAQEYGLPALGISDLMNEFGLVKFYKACRSAGIKPIGAADVWIGNPNAPDKPFRAMLIIRNDAGYLRLSELLTEAYVGKDRNIHHTELNPEWLENGDNSGLICLSGAHYGEVGVNLLNGNEDAARAAALKYAAWFPDAFYLELQRLPERPEWEACVSGSVKLAEELGLPVVATHPTQFMSRDDFNAHEARVCIAGGWVLTDKKRPRDFTPSQFFIPPETMAERFADLPEALENTVEIAKRCNLHITLGKNFLPLFPTPDGLSLDDYLVKLSNEGLQERMVQLYPDEAERAAKMPEYQERLDFELNIIIQMKFPGYFLIVQDFINWAKTHGCPVGPGRGSGAGSLVAYSLKITDLDPLKYALLFERFLNPERVSMPDFDVDFCQANRGRVIEYVREKYGAEAVSQIVTFGTMSSKAVIRDVGRVLELPFMLCDKLSKLIPLEANKPLSLEKAMEAEPQIQELIEAEEADELITLAKKLEDLTRGLGMHAGGVLIAPGKISDYSPVYQADESASPVSMYDKGDVEDVGLVKFDFLGLRNLTIIEMAQNNIKNTTGDIVDVGKIPLDDQAAYQIFRDANTTAVFQFESTGMKKMLKTAHTTKFEELIAFVSLYRPGPMDNIPDFVARMKGQEFQYIHPLLEGILAPTYGIMVYQEQVMQAAQIIGGYSLGGADLLRRAMGKKKPEEMVKHREIFAEGAAKQGISREKSDEIFNYMEKFAGYGFNKSHAAAYALISYQTAWLKAHYPAEFMAATMSSELDNTDQLKHFYDDCRANGIEFLPPDINESDYRFTPYPNMKIRYALGAIKGTGEAAVESIIAARQSGGKFTGLLDFCERVGKEHMNRRTLEALIRGGAFDSIEPNRAMLLANIDLAMNNADQKAANANQGGLFDMMEDAIEPVRLVNAPMWSESEKLTEEKTVIGFYLSGHPFSPYAQEVRQIAPTKLGRLKPQDSVRLAGFVTAVRTMMGKRGKIAFVSLEDLSGQIEIMVSGQTLENCADYLKSDQVLIIESKVSRDDYGGGDGLRIMANQVMTLQMARERYARSLSLALAPGHDIARLAAILTAHRLPDTSHIPLQLSYSNGKASGKLKIAPKWMVTPSTGLFDELETLLGSRSVRVNW
>NZ_LS483369.1|WP_080549666.1|115698_115935_+|RNA-binding-protein
MMEATVYLEDNEYIALCDLLKLAGLAESGGQAKAFIAEGLVLRNGETETRKTAKIRGGEVIEFDGARLEIADGYDPEA
>NZ_LS483369.1|WP_002240002.1|115912_116116_+|hypothetical-protein
MDTTLKHKAEALLGEPLLDEPVRPESWECCGSDCGEACIQTIYWADKARYDAQRRKLKEAGWSDDAV
>NZ_LS483369.1|WP_101119092.1|116247_117084_+|PHP-domain-containing-protein
MIDLHCHSTVSDGMLSPAEVVRLAHQNGCTLLALTDHDHTGGIAEARAEADRLGLRLINGVEISVTWRGRTIHVVGLDFDEQDENLQNLLAQVRQGRLKRLEAIAAKLEKKGIGGAYDGALALAANKEMVSRTHVAEFLIQAGHVKNKQQAFTKYLGDGKSCAVRHEWATLEDCVSAVNGAGGMAVIAHPMRYDLSATAKRNLFEEFKNLGGAGIEVHSGNCCKNDRLNYALLAERFGMLASAGSDFHRLNDFSGGILGACPELPENCRPVWAHFSRH
>NZ_LS483369.1|WP_111726281.1|117136_118429_-|valine--pyruvate-transaminase
MQFSAFGEKFTQHSGILQLMDDLGDALKNDKPVNMLGGGNPARIPEIDRAFADIFSKLATEHAVENIGNYSNPQGDAALIDALTAFLNREYSWNLTADNIALTNGSQNAFFYLFNLFGGKFNLSDGTSAEKAILLPLAPEYIGYADVHVEGQHFVSVKPKIENVEHEGEAGFFKYRVDFDALENLPELKAGKIGAICCSRPTNPTGNVLTDGEMARLDALAREHGIPLIIDNAYGMPFPNIIYSDVTLNWHENIILCFSLSKVGLPGVRTGIIVAAPEVVKAVSSLNAIVNLAPTRFGAAIAAPLLESGEMKRLADQIIRPFYRNQAQTAVSLLKRELGAYPMKIHKPEGAIFLWLWFENLPVSSQTLYEMLKAEGTLIIPGEHFFVGIDTQDYPHAGECIRMSIAQDTQTLEKGIAAIGKTVRKLYDNV
>NZ_LS483369.1|WP_111726283.1|118484_120395_-|polysaccharide-biosynthesis-protein
MTLETLLALPRNIKKICFLIHDFLMIFTAFWFTQSLKADYSNEWFDPANWQSFLLTALLTIGLFVRMGLYRAVTRFVSFHVLTTAFAGSLVSAVLFFLNTLIFEEKLRLALPVVYFLLLLVSVTGSRMVIRGLLSDHQKKHMTPVIIYGAGRSGRQLLEAVKQIREYSAVAFVDDNPKLWHTVIYDLAVYQPNAIAFLIERYGVEKILLAIPSATQEQRRRIISKLEAYPCEVLTIPGMKDLMDGKISIGTLKKISVSDLLGRDSVAPDDRLMNADIAGRTVMVTGAGGSIGSELCRQIIRRRPEKLLLFELSEFALYAIEKELREYCTQNNTDTEILPFLGSVQNRTLLTRIMTAGQVSTVYHAAAYKHVPMVEFNTVEGIRNNIFGTLECALAATASGVRTFVLISTDKAVRPTNTMGASKRMAELCLQALAAKPGQKTRFSMVRFGNVLGSSGSVVPLFEKQIAEGGPLTLTHPEITRYFMTIPEAAQLVIQAGAMGTGGDVFVLDMGESVKIIDLARQMITLSGLKPKTPEQPDGDIEILITGLRPGEKLYEELLIGDNVRKTGHPRIMTANETMLPWHELSALLDRIRSACDRYDQQAIRTLLINAPTGFAPSDGICDLLWVRETHRKNAV
>NZ_LS483369.1|WP_111726284.1|120442_121618_-|DegT/DnrJ/EryC1/StrS-aminotransferase-family-protein
MLNTSLSPWPCFTQEEADAVSKVLLSNKVNYWTGSECREFEKEFAAFAGTRYAVALSNGTLALDVALKAMGIVAGDDVIVTSRTFLASASCIVTAGANPVFADVDLNSQNISAETIKAALTPNTKAIIVVHLAGMPAEMDGIMDLAKEHNLWVIEDCAQAHGAKYKGKSVGSIGHVGAWSFCQDKIMTTGGEGGMVTTNDKALWRKMWSYKDHGKSYDAVYHREHAPGFRWLHESFGTNWRMMEMQAVIGRIQLKRMPEWTARRQAHAAKLAESLGKFASIRLVEVTDYIEHAQYKFYAFVKPEHLKDGWTRDRIVSELNACKVPCYQGSCSEVYLEKAFDNTPWRPKERLKNAVELGDTSLMFLVHPTLTDGEIAFCKEHIEAVLTEATQ

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_LS483369_1	1.1\|106158\|30\|NZ_LS483369\|PILER-CR,CRISPRCasFinder,CRT	106158-106187	30	NZ_CP029602	Streptomyces sp. WAC 01438 plasmid unnamed1, complete sequence	33717-33746	6	0.8
NZ_LS483369_1	1.3\|106290\|30\|NZ_LS483369\|PILER-CR,CRISPRCasFinder,CRT	106290-106319	30	MN693029	Marine virus AFVG_117M56, complete genome	28763-28792	6	0.8
NZ_LS483369_1	1.3\|106290\|30\|NZ_LS483369\|PILER-CR,CRISPRCasFinder,CRT	106290-106319	30	MN692985	Marine virus AFVG_117M57, complete genome	28860-28889	6	0.8
NZ_LS483369_1	1.5\|106422\|30\|NZ_LS483369\|PILER-CR,CRISPRCasFinder,CRT	106422-106451	30	NZ_CP031163	Deinococcus wulumuqiensis strain NEB 479 plasmid pDrdI, complete sequence	518725-518754	6	0.8
NZ_LS483369_1	1.7\|106554\|30\|NZ_LS483369\|PILER-CR,CRISPRCasFinder,CRT	106554-106583	30	NZ_CP015623	Corynebacterium crudilactis strain JZ16 plasmid pCRULAC1, complete sequence	1874-1903	6	0.8
NZ_LS483369_1	1.2\|106224\|30\|NZ_LS483369\|PILER-CR,CRISPRCasFinder,CRT	106224-106253	30	NC_010923	Neisseria lactamica plasmid pNL9, complete sequence	7053-7082	7	0.767
NZ_LS483369_1	1.5\|106422\|30\|NZ_LS483369\|PILER-CR,CRISPRCasFinder,CRT	106422-106451	30	NZ_CP016891	Pantoea agglomerans strain C410P1 plasmid unnamed2, complete sequence	8472-8501	7	0.767
NZ_LS483369_1	1.5\|106422\|30\|NZ_LS483369\|PILER-CR,CRISPRCasFinder,CRT	106422-106451	30	NZ_CP016891	Pantoea agglomerans strain C410P1 plasmid unnamed2, complete sequence	52357-52386	7	0.767
NZ_LS483369_1	1.5\|106422\|30\|NZ_LS483369\|PILER-CR,CRISPRCasFinder,CRT	106422-106451	30	NZ_CP016891	Pantoea agglomerans strain C410P1 plasmid unnamed2, complete sequence	143933-143962	7	0.767
NZ_LS483369_1	1.5\|106422\|30\|NZ_LS483369\|PILER-CR,CRISPRCasFinder,CRT	106422-106451	30	HM144385	Brochothrix phage NF5, complete genome	8728-8757	7	0.767
NZ_LS483369_1	1.1\|106158\|30\|NZ_LS483369\|PILER-CR,CRISPRCasFinder,CRT	106158-106187	30	NZ_LR699074	Beijerinckiaceae bacterium RH AL1 isolate RH_AL1 plasmid 2	28670-28699	9	0.7
NZ_LS483369_1	1.1\|106158\|30\|NZ_LS483369\|PILER-CR,CRISPRCasFinder,CRT	106158-106187	30	NZ_LR699074	Beijerinckiaceae bacterium RH AL1 isolate RH_AL1 plasmid 2	73530-73559	9	0.7
NZ_LS483369_1	1.1\|106158\|30\|NZ_LS483369\|PILER-CR,CRISPRCasFinder,CRT	106158-106187	30	NZ_LR699074	Beijerinckiaceae bacterium RH AL1 isolate RH_AL1 plasmid 2	41999-42028	9	0.7
NZ_LS483369_1	1.1\|106158\|30\|NZ_LS483369\|PILER-CR,CRISPRCasFinder,CRT	106158-106187	30	NZ_LR699074	Beijerinckiaceae bacterium RH AL1 isolate RH_AL1 plasmid 2	66130-66159	9	0.7
NZ_LS483369_1	1.1\|106158\|30\|NZ_LS483369\|PILER-CR,CRISPRCasFinder,CRT	106158-106187	30	NZ_LR699074	Beijerinckiaceae bacterium RH AL1 isolate RH_AL1 plasmid 2	112539-112568	9	0.7

1. spacer 1.1|106158|30|NZ_LS483369|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029602 (Streptomyces sp. WAC 01438 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.8

gtaccggagccgcgtttgccgacacggata	CRISPR spacer
acgtcgtagccgcggttgccgacacggata	Protospacer
....** ******* ***************

2. spacer 1.3|106290|30|NZ_LS483369|PILER-CR,CRISPRCasFinder,CRT matches to MN693029 (Marine virus AFVG_117M56, complete genome) position: , mismatch: 6, identity: 0.8

aataatgacatcgcgtttaatctcttcttc	CRISPR spacer
tattgcgacatcgcgtttaatatctttttc	Protospacer
 ** ..*************** ****.***

3. spacer 1.3|106290|30|NZ_LS483369|PILER-CR,CRISPRCasFinder,CRT matches to MN692985 (Marine virus AFVG_117M57, complete genome) position: , mismatch: 6, identity: 0.8

aataatgacatcgcgtttaatctcttcttc	CRISPR spacer
tattgcgacatcgcgtttaatatctttttc	Protospacer
 ** ..*************** ****.***

4. spacer 1.5|106422|30|NZ_LS483369|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP031163 (Deinococcus wulumuqiensis strain NEB 479 plasmid pDrdI, complete sequence) position: , mismatch: 6, identity: 0.8

ggcgtgaacggtgctgataag--gctgttgca	CRISPR spacer
ggcgtgaacggtgctgatcaggagccgtcc--	Protospacer
****************** **  **.**.

5. spacer 1.7|106554|30|NZ_LS483369|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015623 (Corynebacterium crudilactis strain JZ16 plasmid pCRULAC1, complete sequence) position: , mismatch: 6, identity: 0.8

ttctatctcttggggtgtgaagtgttgtcc	CRISPR spacer
tgcgttttcttggggtgtgcagtgttttcc	Protospacer
* *  *.************ ****** ***

6. spacer 1.2|106224|30|NZ_LS483369|PILER-CR,CRISPRCasFinder,CRT matches to NC_010923 (Neisseria lactamica plasmid pNL9, complete sequence) position: , mismatch: 7, identity: 0.767

actttctaatttacaacgcctccacctatt	CRISPR spacer
actttctaatttaccacgccccccgccgat	Protospacer
************** *****.**  *.. *

7. spacer 1.5|106422|30|NZ_LS483369|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP016891 (Pantoea agglomerans strain C410P1 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.767

ggcgtgaacggtgctgataaggctgttgca	CRISPR spacer
gtcattaacggtgctgacaaggctgttctg	Protospacer
* *.* ***********.********* ..

8. spacer 1.5|106422|30|NZ_LS483369|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP016891 (Pantoea agglomerans strain C410P1 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.767

ggcgtgaacggtgctgataaggctgttgca	CRISPR spacer
gtcattaacggtgctgacaaggctgttctg	Protospacer
* *.* ***********.********* ..

9. spacer 1.5|106422|30|NZ_LS483369|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP016891 (Pantoea agglomerans strain C410P1 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.767

ggcgtgaacggtgctgataaggctgttgca	CRISPR spacer
gtcattaacggtgctgacaaggctgttctg	Protospacer
* *.* ***********.********* ..

10. spacer 1.5|106422|30|NZ_LS483369|PILER-CR,CRISPRCasFinder,CRT matches to HM144385 (Brochothrix phage NF5, complete genome) position: , mismatch: 7, identity: 0.767

ggcgtgaacggtgctgataaggctgttgca	CRISPR spacer
gtcgggaacggtgctgacaaggctggtaag	Protospacer
* ** ************.******* *. .

11. spacer 1.1|106158|30|NZ_LS483369|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR699074 (Beijerinckiaceae bacterium RH AL1 isolate RH_AL1 plasmid 2) position: , mismatch: 9, identity: 0.7

gtaccggagccgcgtttgccgacacggata	CRISPR spacer
aagaagcggccgcgtttgccggcacggatg	Protospacer
. .  * .*************.*******.

12. spacer 1.1|106158|30|NZ_LS483369|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR699074 (Beijerinckiaceae bacterium RH AL1 isolate RH_AL1 plasmid 2) position: , mismatch: 9, identity: 0.7

gtaccggagccgcgtttgccgacacggata	CRISPR spacer
aagaagcggccgcgtttgccggcacggatg	Protospacer
. .  * .*************.*******.

13. spacer 1.1|106158|30|NZ_LS483369|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR699074 (Beijerinckiaceae bacterium RH AL1 isolate RH_AL1 plasmid 2) position: , mismatch: 9, identity: 0.7

gtaccggagccgcgtttgccgacacggata	CRISPR spacer
aagaagcggccgcgtttgccggcacggatg	Protospacer
. .  * .*************.*******.

14. spacer 1.1|106158|30|NZ_LS483369|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR699074 (Beijerinckiaceae bacterium RH AL1 isolate RH_AL1 plasmid 2) position: , mismatch: 9, identity: 0.7

gtaccggagccgcgtttgccgacacggata	CRISPR spacer
aagaagcggccgcgtttgccggcacggatg	Protospacer
. .  * .*************.*******.

15. spacer 1.1|106158|30|NZ_LS483369|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR699074 (Beijerinckiaceae bacterium RH AL1 isolate RH_AL1 plasmid 2) position: , mismatch: 9, identity: 0.7

gtaccggagccgcgtttgccgacacggata	CRISPR spacer
aagaagcggccgcgtttgccggcacggatg	Protospacer
. .  * .*************.*******.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

439220 : 557534

115

uncultured_Caudovirales_phage(12.0%)

protease,integrase,tRNA,portal,terminase,capsid,head,tail

attL 450143:450169|attR 551476:551502

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_111726613.1\|439220_440060_-\|protease	protease HtpX	NA	NA	NA	NA
WP_111726615.1\|440278_440926_+	adenylate kinase	NA	NA	NA	NA
WP_111726617.1\|441032_441773_+	orotidine-5'-phosphate decarboxylase	NA	NA	NA	NA
WP_111726619.1\|441827_442790_+	ADP-heptose synthase	M4QF80	Synechococcus_phage	1.0e-15	29.6
WP_111726621.1\|442855_443860_+	ADP-glyceromanno-heptose 6-epimerase	E3SL51	Synechococcus_phage	3.0e-26	33.3
WP_167395518.1\|443937_445479_+	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	9.6e-101	41.7
WP_079870635.1\|445595_445679_+	DNA-damage-inducible D domain protein	NA	NA	NA	NA
WP_111726625.1\|445823_446417_+	restriction endonuclease subunit S	F2Y1N5	Organic_Lake_phycodnavirus	1.8e-07	27.8
WP_167395586.1\|446433_446961_+	restriction endonuclease subunit S	NA	NA	NA	NA
WP_111726628.1\|447039_450138_+	type I restriction endonuclease subunit R	A0A220A398	Liberibacter_phage	4.5e-25	22.9
450143:450169	attL	NA	NA	NA	NA
WP_111726630.1\|450176_452468_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpA	A0A223W0B1	Agrobacterium_phage	2.7e-168	42.5
WP_111726632.1\|452469_452772_-\|protease	ATP-dependent Clp protease adapter ClpS	NA	NA	NA	NA
WP_003682902.1\|453021_453225_+	cold-shock protein	A0A2H4N7Y6	Lake_Baikal_phage	2.6e-22	78.8
WP_111726634.1\|453550_454882_-\|protease	metalloprotease PmbA	NA	NA	NA	NA
WP_107996968.1\|455034_455547_+	ribosome-associated protein	NA	NA	NA	NA
WP_111726636.1\|455593_456307_+	hypothetical protein	NA	NA	NA	NA
WP_111726639.1\|456375_458076_+	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	2.6e-67	31.1
WP_111726640.1\|458138_459062_+	DMT family transporter	NA	NA	NA	NA
WP_111726642.1\|459138_460527_-	class II fumarate hydratase	NA	NA	NA	NA
WP_111726644.1\|460675_462655_-	transketolase	NA	NA	NA	NA
WP_111726646.1\|463218_464715_+	cytochrome c oxidase accessory protein CcoG	NA	NA	NA	NA
WP_039853826.1\|464717_465266_+	FixH family protein	NA	NA	NA	NA
WP_107819648.1\|465325_466501_-	nitronate monooxygenase	NA	NA	NA	NA
WP_111726648.1\|467092_468505_+	3'-5' exonuclease	G3MAD3	Bacillus_virus	1.2e-09	29.8
WP_050892787.1\|468715_469495_-	ferredoxin--NADP reductase	NA	NA	NA	NA
WP_111726651.1\|469768_472858_+	TonB-dependent siderophore receptor	NA	NA	NA	NA
WP_111726653.1\|473001_474060_+	DNA polymerase IV	I6RSM4	Salmonella_phage	2.6e-17	31.6
WP_111726655.1\|474158_476174_-	DNA helicase Rep	A7KV33	Bacillus_phage	6.9e-107	36.6
WP_111726657.1\|476193_476958_-	type I 3-dehydroquinate dehydratase	W6LP76	Streptococcus_phage	1.3e-18	33.3
WP_107960220.1\|477157_478204_+	recombinase RecA	A0A2D1GPX2	Mycobacterium_phage	2.4e-119	64.6
WP_111726659.1\|478367_479288_-	aromatic amino acid DMT transporter YddG	NA	NA	NA	NA
WP_107859161.1\|479412_479748_-	YbaB/EbfC family nucleoid-associated protein	NA	NA	NA	NA
WP_111726661.1\|479829_482013_-	DNA polymerase III subunit gamma/tau	A0A1U9WR94	Streptococcus_virus	1.6e-45	39.6
WP_111726663.1\|482100_484077_-	DNA mismatch repair endonuclease MutL	A0A1B2LRQ5	Wolbachia_phage	7.2e-85	31.9
WP_002213027.1\|484220_484406_+	DUF3460 family protein	NA	NA	NA	NA
WP_107859157.1\|484416_485085_+	O-methyltransferase	NA	NA	NA	NA
WP_111726665.1\|485084_485801_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_111726666.1\|485848_486334_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	8.1e-22	43.1
WP_111727614.1\|486405_487707_-	3-phosphoshikimate 1-carboxyvinyltransferase	NA	NA	NA	NA
WP_003709053.1\|488104_488581_+	transcription elongation factor GreA	NA	NA	NA	NA
WP_003674519.1\|488689_488884_-	hypothetical protein	NA	NA	NA	NA
WP_003674521.1\|489031_489214_+	hypothetical protein	NA	NA	NA	NA
WP_111726670.1\|489274_490261_-\|tRNA	tRNA-dihydrouridine synthase	NA	NA	NA	NA
WP_111726672.1\|490395_491583_+\|integrase	tyrosine-type recombinase/integrase	A0A2H4J8L8	uncultured_Caudovirales_phage	1.6e-84	44.3
WP_111726674.1\|491641_492136_-	DUF4760 domain-containing protein	NA	NA	NA	NA
WP_111726676.1\|492453_492717_-	transcriptional regulator	NA	NA	NA	NA
WP_167395519.1\|492781_493729_-	SAM-dependent methyltransferase	A0A0M3LQ47	Mannheimia_phage	1.1e-96	57.5
WP_167395520.1\|493700_493931_-	hypothetical protein	A0A0M3LSX3	Mannheimia_phage	3.6e-12	58.1
WP_111726680.1\|494220_494859_-	hypothetical protein	NA	NA	NA	NA
WP_111726682.1\|494981_495242_-	hypothetical protein	NA	NA	NA	NA
WP_111726685.1\|495276_495492_-	hypothetical protein	NA	NA	NA	NA
WP_111726687.1\|495596_495812_-	hypothetical protein	NA	NA	NA	NA
WP_167395587.1\|496052_496478_-	hypothetical protein	NA	NA	NA	NA
WP_111726691.1\|496580_497279_-	helix-turn-helix domain-containing protein	Q7Y5W5	Haemophilus_phage	1.7e-52	55.1
WP_111726693.1\|497392_497623_+	hypothetical protein	NA	NA	NA	NA
WP_111726695.1\|497784_498132_+	hypothetical protein	NA	NA	NA	NA
WP_111726697.1\|498246_501093_+	DNA primase	A0A2H4JF22	uncultured_Caudovirales_phage	1.8e-73	32.4
WP_111726699.1\|501691_502072_+	hypothetical protein	NA	NA	NA	NA
WP_111726701.1\|502220_502538_+	HNH endonuclease	A0A0R6PHK1	Moraxella_phage	1.6e-10	37.6
WP_111726703.1\|502728_503316_+\|terminase	terminase small subunit	A0A2H4J8R0	uncultured_Caudovirales_phage	5.8e-14	35.7
WP_111726705.1\|503309_504998_+\|terminase	terminase large subunit	Q3HQS7	Burkholderia_phage	1.1e-190	58.2
WP_111726707.1\|505006_506248_+\|portal	phage portal protein	Q3HQS8	Burkholderia_phage	5.0e-108	51.1
WP_111726709.1\|506219_507065_+\|protease	Clp protease ClpP	Q3HQS9	Burkholderia_phage	7.1e-74	54.1
WP_111726711.1\|507068_508304_+\|capsid	phage major capsid protein	Q3HQT0	Burkholderia_phage	1.3e-108	52.9
WP_111726713.1\|508397_508685_+	hypothetical protein	NA	NA	NA	NA
WP_111726715.1\|508681_508999_+\|head,tail	phage gp6-like head-tail connector protein	Q6JIM5	Burkholderia_virus	2.9e-12	43.1
WP_111727617.1\|509210_509426_+	hypothetical protein	NA	NA	NA	NA
WP_111726717.1\|509428_509830_+	DUF3310 domain-containing protein	A0A088FRG2	Mycobacterium_phage	1.0e-09	57.1
WP_111726719.1\|509883_510513_+	hypothetical protein	NA	NA	NA	NA
WP_111726721.1\|510567_510900_+\|head	phage head closure protein	A0A2H4JC00	uncultured_Caudovirales_phage	1.9e-06	31.5
WP_111726723.1\|510883_511405_+	hypothetical protein	NA	NA	NA	NA
WP_167395521.1\|511385_511724_+	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_111726727.1\|511792_512437_+\|tail	phage tail protein	A0A0H5BBY3	Pseudomonas_phage	6.7e-48	46.9
WP_111726729.1\|512508_512826_+	hypothetical protein	A0A2H4IYQ5	uncultured_Caudovirales_phage	5.1e-09	29.9
WP_111727619.1\|512876_513146_+	DUF1799 domain-containing protein	E7EKR1	Edwardsiella_phage	2.4e-07	43.2
WP_111726731.1\|513138_516348_+\|tail	phage tail protein	A0A2H4J107	uncultured_Caudovirales_phage	2.0e-39	32.2
WP_111726733.1\|516370_516697_+\|tail	phage tail protein	Q3HQU0	Burkholderia_phage	1.5e-16	41.5
WP_111726736.1\|516720_517404_+\|tail	phage minor tail protein L	Q9FZU6	Neisseria_meningitidis_phage	6.4e-73	70.4
WP_111726738.1\|517405_518152_+	C40 family peptidase	Q9FZU5	Neisseria_meningitidis_phage	3.6e-69	53.3
WP_111726740.1\|518148_518970_+\|tail	tail assembly protein	Q9FZU4	Neisseria_meningitidis_phage	1.5e-52	46.1
WP_167395522.1\|518959_522838_+	DUF1983 domain-containing protein	Q9FZU3	Neisseria_meningitidis_phage	6.9e-281	56.9
WP_111726744.1\|523165_525154_+	hypothetical protein	NA	NA	NA	NA
WP_111726745.1\|525205_525523_+	hypothetical protein	NA	NA	NA	NA
WP_111727621.1\|525587_526049_+	hypothetical protein	NA	NA	NA	NA
WP_111726746.1\|526049_526382_+	hypothetical protein	NA	NA	NA	NA
WP_167395523.1\|526368_526704_+	hypothetical protein	NA	NA	NA	NA
WP_145960423.1\|526874_527246_+	hypothetical protein	NA	NA	NA	NA
WP_111726749.1\|527289_527949_+	hypothetical protein	Q708K2	Streptococcus_phage	6.2e-41	50.0
WP_111726751.1\|527958_528423_+	DUF4376 domain-containing protein	A0A0R6PGN1	Moraxella_phage	2.0e-30	47.2
WP_111726753.1\|528419_528884_+	hypothetical protein	A0A0R6PGL8	Moraxella_phage	3.7e-32	50.7
WP_111726755.1\|528896_529394_+	TIGR02594 family protein	A0A0B5L5G5	Acinetobacter_phage	3.7e-46	54.8
WP_111726757.1\|530724_530886_+	hypothetical protein	NA	NA	NA	NA
WP_111726759.1\|530911_531802_-	Rha family transcriptional regulator	D0UIK6	Aggregatibacter_phage	1.3e-17	39.7
WP_111726761.1\|532368_533409_+	hypothetical protein	A0A0N7KZA9	Stx2-converting_phage	2.2e-56	42.3
WP_167395524.1\|533481_533664_-	hypothetical protein	NA	NA	NA	NA
WP_167395525.1\|533721_533889_-	hypothetical protein	NA	NA	NA	NA
WP_111726765.1\|534222_534384_+	hypothetical protein	NA	NA	NA	NA
WP_111726767.1\|534811_538645_-	FAD/FMN-binding oxidoreductase	NA	NA	NA	NA
WP_107996991.1\|539174_540866_+	D-lactate dehydrogenase	NA	NA	NA	NA
WP_111726769.1\|541054_541426_+	DUF2628 domain-containing protein	NA	NA	NA	NA
WP_003674530.1\|541585_542134_+	carboxymuconolactone decarboxylase family protein	NA	NA	NA	NA
WP_107996993.1\|542229_543321_+	acyl-CoA/acyl-ACP dehydrogenase	NA	NA	NA	NA
WP_003674535.1\|543445_543616_+	rubredoxin	NA	NA	NA	NA
WP_111726771.1\|543729_545799_-	TonB-dependent receptor	NA	NA	NA	NA
WP_111726773.1\|546095_548852_-	DNA gyrase subunit A	G3M9Z5	Bacillus_virus	7.2e-91	33.0
WP_111726777.1\|549404_549905_-	Fe-S protein assembly co-chaperone HscB	NA	NA	NA	NA
WP_108043922.1\|549987_550209_+	alternative ribosome-rescue factor A	NA	NA	NA	NA
WP_003680782.1\|550168_550489_-	iron-sulfur cluster assembly protein IscA	A0A2H4N7N5	Lake_Baikal_phage	6.3e-23	49.5
WP_003674559.1\|550853_551240_-	Fe-S cluster assembly scaffold IscU	A0A218MKD1	uncultured_virus	1.9e-53	77.3
WP_111726779.1\|551515_552730_-	IscS subfamily cysteine desulfurase	H7BUW1	unidentified_phage	6.1e-34	38.2
551476:551502	attR	NA	NA	NA	NA
WP_107859140.1\|552759_553206_-	Fe-S cluster assembly transcriptional regulator IscR	NA	NA	NA	NA
WP_107997001.1\|553560_554733_+	alpha-hydroxy-acid oxidizing protein	NA	NA	NA	NA
WP_111727624.1\|554797_555721_-\|tRNA	tRNA pseudouridine(55) synthase TruB	NA	NA	NA	NA
WP_002241698.1\|555753_556125_-	30S ribosome-binding factor RbfA	NA	NA	NA	NA
WP_107997003.1\|556289_557534_+\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	1.6e-130	57.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage