CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_LS483414	Streptococcus pyogenes strain NCTC13736 chromosome 1	2 crisprs	DEDDh,cas3,csm6,DinG,csa3	1	0	9	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_LS483414_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LS483414_1

121524-121712

Orphan

Consensus_repeat	Method
AGAGTTAGATGGCCAAGAAGTCCCAGAAGTTCCAAGCGAGAGCTTAGAACC	PILER-CR

2 spacers

The CRISPR arrays of NZ_LS483414_1

>merge|NZ_LS483414|1|121524-121712|PILER-CR
AGATTTAGATGGGCATGAAATCCCAGAAGTTCCACAAGAACCTTCAGACCCAGTTATCCCACCAGTTATTTTGGATGGTGAAGAAGTCCCAGAAGTTCCAAGCGAGAGCTTAGAACCTGCGCTTCCCCCATTAATGCCAGAGCTAGATGGCCAAGAAGTCCCAGAAGTTTCAAGCGAGAGCTTAGAACC

>NZ_LS483414|1|1|121524-121712|PILER-CR
AGATTTAGATGGGCATGAAATCCCAGAAGTTCCACAAGAACCTTCAGACCC	AGTTATCCCACCAGTTATTTTGGATGGTGAAGAAGT
CCCAGAAGTTCCAAGCGAGAGCTTAGAACCTGCGCTTCCCCCATTAATGCC	AGAGCTAGATGGCCAAGAAGT
CCCAGAAGTTTCAAGCGAGAGCTTAGAACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LS483414.1\|WP_003053955.1\|115620_116016_+\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|180914
NZ_LS483414.1\|WP_011284435.1\|122777_123626_+\|class-C-sortase	unknown	unknown	gnl\|CDD\|320676
NZ_LS483414.1\|WP_002986504.1\|116275_116917_-\|deoxynucleoside-kinase	unknown	unknown	gnl\|CDD\|224345
NZ_LS483414.1\|WP_030127394.1\|112694_113762_-\|glutamyl-aminopeptidase	unknown	unknown	gnl\|CDD\|132151
NZ_LS483414.1\|WP_002987832.1\|126168_126690_+\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NZ_LS483414.1\|WP_023611495.1\|126711_127740_+\|QVPTGV-class-sortase-B-protein-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|274781
NZ_LS483414.1\|WP_076636739.1\|123911_126176_+\|pilus-ancillary-protein-1	unknown	unknown	gnl\|CDD\|380246
NZ_LS483414.1\|WP_152539042.1\|128497_129085_+\|fimbrial-protein	unknown	unknown	gnl\|CDD\|274781
NZ_LS483414.1\|WP_030127392.1\|117900_118773_-\|Hsp33-family-molecular-chaperone-HslO	unknown	unknown	gnl\|CDD\|234643
NZ_LS483414.1\|WP_030127393.1\|116936_117914_-\|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl\|CDD\|129820
NZ_LS483414.1\|WP_030127385.1\|135587_136994_+\|short-chain-fatty-acid-transporter	unknown	unknown	gnl\|CDD\|224942
NZ_LS483414.1\|WP_030127387.1\|130817_134303_+\|fibronectin-binding-protein	unknown	unknown	gnl\|CDD\|380245
NZ_LS483414.1\|WP_002986511.1\|114842_115469_+\|DUF4479-and-tRNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|239196
NZ_LS483414.1\|WP_002986515.1\|114507_114825_+\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NZ_LS483414.1\|WP_030127386.1\|134569_135235_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LS483414.1\|WP_030127395.1\|111876_112647_-\|pyrroline-5-carboxylate-reductase	unknown	unknown	gnl\|CDD\|237008
NZ_LS483414.1\|WP_076636737.1\|118914_120408_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|285470
NZ_LS483414.1\|WP_030127390.1\|127755_128481_+\|class-B-sortase	unknown	unknown	gnl\|CDD\|211782
NZ_LS483414.1\|WP_111705974.1\|129227_130433_-\|YSIRK-targeted-surface-antigen-transcriptional-regulator	unknown	unknown	gnl\|CDD\|274977
NZ_LS483414.1\|WP_002986518.1\|114217_114511_+\|DUF4651-domain-containing-protein	unknown	unknown	gnl\|CDD\|339494

Protein	Function_ID	Function_description	E-value
NZ_LS483414.1\|WP_003053955.1\|115620_116016_+\|single-stranded-DNA-binding-protein	gnl\|CDD\|180914	PRK07274, PRK07274, single-stranded DNA-binding protein; Provisional.	1.44411e-89
NZ_LS483414.1\|WP_011284435.1\|122777_123626_+\|class-C-sortase	gnl\|CDD\|320676	cd05827, Sortase_C, Sortase domain found in class C sortases. Class C sortases are membrane-bound cysteine transpeptidases broadly distributed in Gram-positive bacteria (mainly present in Firmicutes and Actinobacteria). They function as pilin polymerases responsible for the assembly of pili, which are multi-subunit hair-like fibres that extend from the cell surface to promote microbial adhesion and biofilm formation. First, one or more class C sortases form the long thin shaft of the pilus through linking together pilin subunits via isopeptide bonds. The base of the pilus is then anchored to the cell wall by a housekeeping sortase or, in some cases, the class C sortase itself. Depending upon the organism both the number and type of sortase enzymes involved varies, and in some cases, accessory factors appear to be needed. In three-component spaA pilus from Corynebacterium diphtheriae, the prototypical class C sortase (named Cd-SrtA) catalyzes polymerization of the SpaA-type pilus, consisting of the shaft pilin SpaA, tip pilin SpaC and minor pilin SpaB. The pilus shaft is then attached to the cell wall by a housekeeping class E sortase, Cd-SrtF. In the absence of Cd-SrtF, Cd-SrtA attaches the pilus to the cell wall, albeit at a reduced rate. Cd-SrtA can recognize two distinct sorting signals (LPLTG in SpaA and SpaC, and LAFTG in SpaB) and it can employ lysine residues that originate from different proteins (either Lys190 within the pilin motif of SpaA or Lys139 in SpaB). However, Cd-SrtA cannot be able to polymerize the major pilin subunit SpaH, even though it contains LPLTG motif. In two-component pili of prototypical Bacillus cereus, the class C sortase (named Bc-SrtD) cleaves related sorting signals within a major pilin protein BcpA (LPVTG) and a minor tip pilin BcpB (IPNTG), and catalyzes a transpeptidation that joins the threonine residues in each signal to the side-chain of Lys162 in BcpA (located within a pilin motif). Unlike the SpaA pilus in C. diphtheriae, in B. cereus Bc-SrtD is unable to covalently attach the pilus to the cell wall without the help of the housekeeping sortase.	3.71843e-74
NZ_LS483414.1\|WP_002986504.1\|116275_116917_-\|deoxynucleoside-kinase	gnl\|CDD\|224345	COG1428, COG1428, Deoxynucleoside kinases [Nucleotide transport and metabolism].	1.2135e-96
NZ_LS483414.1\|WP_030127394.1\|112694_113762_-\|glutamyl-aminopeptidase	gnl\|CDD\|132151	TIGR03107, Glutamyl_aminopeptidase, glutamyl aminopeptidase. This model represents the M42.001 clade within MEROPS family M42. M42 includes glutamyl aminopeptidase as in the present model, deblocking aminopeptidases as from Pyrococcus horikoshii and related species, and endo-1,4-beta-glucanase (cellulase M) as from Clostridium thermocellum. The current family includes [Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NZ_LS483414.1\|WP_002987832.1\|126168_126690_+\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	1.50224e-38
NZ_LS483414.1\|WP_023611495.1\|126711_127740_+\|QVPTGV-class-sortase-B-protein-sorting-domain-containing-protein	gnl\|CDD\|274781	TIGR03786, strep_pil_rpt, streptococcal pilin isopeptide linkage domain. This model describes a domain that occurs once in the major pilin of Streptococcus pyogenes, Spy0128, but in higher copy numbers in other streptococcal proteins. The domain occurs nine times in a surface-anchored protein of Bifidobacterium longum. All members of this family have LPXTG-type sortase target sequences. The S. pyogenes major pilin has been shown to undergo isopeptide bond cross-linking, mediated by sortases, that are critical to maintaining pilus structural integrity. One such Lys-to-Asn isopeptide bond is to a near-invariant Asn near the C-terminal end of this domain (column 81 of the seed alignment). A Glu in the S. pyogenes major pilin (column 25 of the seed alignment), invariant as Glu or Gln, is described as catalytic for isopeptide bond formation.	2.79167e-16
NZ_LS483414.1\|WP_076636739.1\|123911_126176_+\|pilus-ancillary-protein-1	gnl\|CDD\|380246	NF033396, pilus_ancill_1, pilus ancillary protein 1.	0
NZ_LS483414.1\|WP_152539042.1\|128497_129085_+\|fimbrial-protein	gnl\|CDD\|274781	TIGR03786, strep_pil_rpt, streptococcal pilin isopeptide linkage domain. This model describes a domain that occurs once in the major pilin of Streptococcus pyogenes, Spy0128, but in higher copy numbers in other streptococcal proteins. The domain occurs nine times in a surface-anchored protein of Bifidobacterium longum. All members of this family have LPXTG-type sortase target sequences. The S. pyogenes major pilin has been shown to undergo isopeptide bond cross-linking, mediated by sortases, that are critical to maintaining pilus structural integrity. One such Lys-to-Asn isopeptide bond is to a near-invariant Asn near the C-terminal end of this domain (column 81 of the seed alignment). A Glu in the S. pyogenes major pilin (column 25 of the seed alignment), invariant as Glu or Gln, is described as catalytic for isopeptide bond formation.	1.79184e-20
NZ_LS483414.1\|WP_030127392.1\|117900_118773_-\|Hsp33-family-molecular-chaperone-HslO	gnl\|CDD\|234643	PRK00114, hslO, Hsp33 family molecular chaperone HslO.	2.03039e-148
NZ_LS483414.1\|WP_030127393.1\|116936_117914_-\|tRNA-dihydrouridine-synthase-DusB	gnl\|CDD\|129820	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family. This model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). This branch includes NifR3 itself, from Rhodobacter capsulatus. It excludes a broadly distributed but more sparsely populated subfamily that contains sll0926 from Synechocystis PCC6803, HI0634 from Haemophilus influenzae, and BB0225 from Borrelia burgdorferi. It also excludes a shorter and more distant archaeal subfamily.The function of nifR3, a member of this family, is unknown, but it is found in an operon with nitrogen-sensing two component regulators in Rhodobacter capsulatus.Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase. [Unknown function, General].	4.70635e-122
NZ_LS483414.1\|WP_030127385.1\|135587_136994_+\|short-chain-fatty-acid-transporter	gnl\|CDD\|224942	COG2031, AtoE, Short chain fatty acids transporter [Lipid metabolism].	0
NZ_LS483414.1\|WP_030127387.1\|130817_134303_+\|fibronectin-binding-protein	gnl\|CDD\|380245	NF033395, fibronec_SfbI, fibronectin-binding protein SfbI. SfbI is a fibronectin-binding protein a C-terminal region LPXTG region that mediates processing by sortase and covalent attachment to the cell wall. Near the N-terminus is a TED domain, which includes a Cys residue that forms a covalent thioester bond.	3.60511e-28
NZ_LS483414.1\|WP_002986511.1\|114842_115469_+\|DUF4479-and-tRNA-binding-domain-containing-protein	gnl\|CDD\|239196	cd02796, tRNA_bind_bactPheRS, tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate the 2'OH of the terminal ribose of tRNA they belong functionally to class 1 aaRSs. This domain has general tRNA binding properties and is believed to direct tRNAphe to the active site of the enzyme.	1.22775e-48
NZ_LS483414.1\|WP_002986515.1\|114507_114825_+\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	1.40404e-25
NZ_LS483414.1\|WP_030127395.1\|111876_112647_-\|pyrroline-5-carboxylate-reductase	gnl\|CDD\|237008	PRK11880, PRK11880, pyrroline-5-carboxylate reductase; Reviewed.	5.09407e-107
NZ_LS483414.1\|WP_076636737.1\|118914_120408_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|285470	pfam08270, PRD_Mga, M protein trans-acting positive regulator (MGA) PRD domain. Mga is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions. This corresponds to the PRD like region.	2.3973e-61
NZ_LS483414.1\|WP_030127390.1\|127755_128481_+\|class-B-sortase	gnl\|CDD\|211782	TIGR03064, sortase_srtB, sortase, SrtB family. Members of this transpeptidase family are, in most cases, designated sortase B, product of the srtB gene. This protein shows only distant similarity to the sortase A family, for which there may be several members in a single bacterial genome. Typical SrtB substrate motifs include NAKTN, NPKSS, etc, and otherwise resemble the LPXTG sorting signals recognized by sortase A proteins. [Cell envelope, Other, Protein fate, Protein and peptide secretion and trafficking].	5.60673e-104
NZ_LS483414.1\|WP_111705974.1\|129227_130433_-\|YSIRK-targeted-surface-antigen-transcriptional-regulator	gnl\|CDD\|274977	TIGR04094, AraC_family_transcriptional_regulator, YSIRK-targeted surface antigen transcriptional regulator. Bacteria whose genomes encode only one protein with the YSIRK variant form of signal peptide (TIGR01168) were examined for conserved genes near that one tagged protein. This protein is found adjacent to at various classes of repetitive or low-complexity YSIRK proteins (whether unique in genome or not), in a range of species (Enterococcus faecalis X98, Ruminococcus torques, Coprobacillus sp. D7, Lysinibacillus fusiformis ZC1, Streptococcus equi subsp. equi 4047, etc). The affliated YSIRK proteins include Streptococcal protective antigen (see ) and proteins with the Rib/alpha/Esp surface antigen repeat (see TIGR02331). The last quarter of this protein has an AraC family helix-turn-helix (HTH)transcriptional regulator domain.	2.27782e-71
NZ_LS483414.1\|WP_002986518.1\|114217_114511_+\|DUF4651-domain-containing-protein	gnl\|CDD\|339494	pfam15513, DUF4651, Domain of unknown function (DUF4651). family of short, secreted proteins specific to the Streptococcus genus, with distant homologs, not recognized by this HMM, found in other cocci. In all sequenced genomes, proteins from this family appear in a conserved genomic context with an thioredoxin, tRNA synthase and tRNA binding protein, but the functional implication of this is unclear.	8.86115e-29

>NZ_LS483414.1|WP_076636737.1|118914_120408_-|helix-turn-helix-domain-containing-protein
MIEKYLESSIESKCQLVVLFFKTSYLPITEVAEKTGLTFLQLNHYCEELNAFFPGSLSMTIQKRMISCQFTHPFKETYLYQLYASSNVLQLLAFLIKNGSHSRPLTDFARSHFLSNSSAYRMREALIPLLRNFELKLSKNKIVGEEYRIRYLIALLYSKFGIKVYDLTQQDKNTIHSFLSHSSTHLKTSPWLSESFSFYDILLALSWKRHQFSVTIPQTRIFQQLKKLFVYDSLKKSSHDIIETYCQLNFSAGDLDYLYLIYITANNSFASLQWTPEHIRQCCQLFEENDTFRLLLNPIITLLPNLKEQKASLVKALMFFSKSFLFNLQHFIPETNLLVSPYYKGNQRLYTSLKLIVEEWMAKLPGKRYLNHKHFHLFCHYVEQILRNIQPPLVVVFVASNFINAHLLTDSFPRYFSDKSIDFHSYYLLQDNVYQIPGLKPDLVITHSQLIPFVQHELTKGIAVAEISFDESILSIQELMYQVKEEKFQADLTKQLT
>NZ_LS483414.1|WP_030127392.1|117900_118773_-|Hsp33-family-molecular-chaperone-HslO
MDKIIKSISQSGAFRAYVLDSTETVALAQEKHNTLSSSTVALGRTLIANQILAANQKGDSKITVKVIGDSSFGHIISVADTKGHVKGYIQNTGVDIKKTATGEVLVGPFMGNGHFVTIIDYGTGNPYTSTTPLITGEIGEDFAYYLTESEQTPSAIGLNVLLDENDKVKVAGGFMVQVLPGASEEEIARYEKRLQEMPAISHLLASKNHVDALLEAIYGDEPYKRLSEEPLSFQCDCSRERFEAALMTLPKADLQAMIDEDKGAEIVCQFCGTKYQFNESDLEALINDKA
>NZ_LS483414.1|WP_030127393.1|116936_117914_-|tRNA-dihydrouridine-synthase-DusB
MTKLNSSFRIGDVEIPHRTVLAPMAGVTNSAFRTIAKEFGAGLVVMEMISEKGLLYNNEKTLHMLHIDENEHPMSIQLFGGDAEGLKRAADFIQTNTKADIVDINMGCPVNKVVKNEAGAKWLRDPDKIYHIVKEVTSVLDIPLTVKMRTGWADSSLAVENALAAESAGVSALAMHGRTREQMYTGTCDHDTLARVSKAITKIPFIGNGDVRSVQDAKFMIEEIGVDAVMIGRAAMNNPYLFTQINHFFETGQELPDLPFAKKLDIAKDHLKRLINLKGETIAVREFRGLAPHYLRGTAGAAKVRGAVSRAETLAEVEAIFETVR
>NZ_LS483414.1|WP_002986504.1|116275_116917_-|deoxynucleoside-kinase
MLIVLAGTIGAGKSSLAAALGEHLGTDVFYEAVDNNPVLDLYYQDPKKYAFLLQIYFLNKRFKSIKEAYQADNNILDRSIFEDELFLKLNYKNGNVTKTELDIYQELLANMLEELEGMPKKRPDLLIYIDVSFDKMLERIEKRGRSFEQVDGNPSLEQYYHQVHGEYPTWYEDYKVSPKMKIDGNSLDFVQNPQDLATVLKMIDTKLKELHLL
>NZ_LS483414.1|WP_003053955.1|115620_116016_+|single-stranded-DNA-binding-protein
MYNKVIAIGRLVAKPELVKTATDKHVARLSLAVNRRFKNASGEREADFISVVVWGKLAETLVSYASKGSLMSIDGELRTRKYDKDGQVHYVTEVLCQSFQLLESRAQRAMRENNVTNDLVDLVLEEDTLPF
>NZ_LS483414.1|WP_002986511.1|114842_115469_+|DUF4479-and-tRNA-binding-domain-containing-protein
MIFAYNKEQVGDVLMVILQDTKDIKRQVERKGKVARVFAEESGKTLAWNIFEASSLITIEGNGQIFLTDEDLARLNAELAKEGFSERLEPTVGPVFVVGQIVEMVAHPDSDHLNICQVAIGEDQTVQIVAGAPNAALGLKTIVALPGAIMPNGSLIFPGKLRGEESYGMMCSPRELALPNAPQKRGIIELDESAVVGEAFDPAKHWKG
>NZ_LS483414.1|WP_002986515.1|114507_114825_+|thioredoxin-family-protein
MIRPTSYESLAALIEKEDKLVLFFTADWCPDCQFIYPIMPEIEAELTDMTFVCVNRDQFIEVAQKWDIFGIPSFVVIEKGQEVGRLVNKMRKTKTEIMHFLAAYQ
>NZ_LS483414.1|WP_002986518.1|114217_114511_+|DUF4651-domain-containing-protein
MRDMSKKKIGMISGIFGFSLAIGLGIVIKDYCQDRQRRQMTRDLRTFFSPLGQIEVLYINPCQVKQDYISGGVVMSNGKQYQFTYHSRQISFEEDKG
>NZ_LS483414.1|WP_030127394.1|112694_113762_-|glutamyl-aminopeptidase
MTDLFSKIKEVTELDGIAGYEHSVRDYLRTKITPLVDRVETDGLGGIFGIRDSKAEKAPRILVAAHMDEVGFMISDIKVDGTLRVVGIGGWNPLVVSSQRFTLYTRTGQVIPLISGSVPPHFLRGANGSASLPHIEDIVFDGGFTDKAEAERFGITPGDIIVPQSETILTANQKNIISKAWDNRYGVLMITEMLEALKGQDLNNTLIAGANVQEEVGLRGAHVSTTKFDPELFFAVDCSPAGDIYGNPGTIGDGTLLRFYDPGHVMLKDMRDFLLTTAEDAGVNFQYYCGKGGTDAGAAHLQNGGVPSTTIGVCARYIHSHQTLYAMDDFVEAQTFLQAIIKKLDRSTVDLIKRY
>NZ_LS483414.1|WP_030127395.1|111876_112647_-|pyrroline-5-carboxylate-reductase
MKIGIIGVGKMASAIIKGLKQTPHELIISGSSLERSKEIAEQLTLPYAMSHQDLIDQVDLVILGIKPQLFETVLKPLHFKQPIISMAAGISLQRLATFVGQDLPLLRIMPNMNAQILQSSTALTGNALVSQELQARVRGLTDSFGSTFDISEKDFDTFTALAGSSPAYIYLFIEALAKAGVKNGMPKAKALEIVTQTVLASASNLKTSSQSPHDLIDAICSPGGTTIAGLMELERLGLTTTVSSAIDKTIDKAKSL
>NZ_LS483414.1|WP_011284435.1|122777_123626_+|class-C-sortase
MTERLKNLGILLLFLLGTAIFLYPTLSSQWNAYRDRQLLSTYHKQVTQKKPSEMEEVWQKAKAYNARLGIQPVPDAFSFRDGIHDKNYESLLQIENNDIMGYVEVPSIKVTLPIYHYTTDEVLTKGAGHLVGSALPVGGDGTHTVISAHRGLPSAEMFTNLNLVKRGDTFYFRVLNKVLAYKVDQILTVEPDQVTSLSGVMGKDYATLVTCTPYGVNTKRLLVRGHRIAYHYKKYQQAKKAMKLVDKSRMWTEVVCAAFGVVIAIILVFMYSKMTDKKVIKN
>NZ_LS483414.1|WP_076636739.1|123911_126176_+|pilus-ancillary-protein-1
MNNKKLQKKQDAPRVSNRKPKQLTVTLVGVFLMLLVLIGFEGKVRAAHELVEVPVPIFHNPDPQSDYQWYGYEAYTGGYPKYDLFKTYYHDLRVNLHGSKSYQVYCFNVHKHYPRSSQSFDRKWYKKLDGTAENFDSLAMEPRVRKEELTKKLRAVMYNAYPNDANGIMKDLEPLNAIKVTQEAVWYYSDNSPINPDESFKSEALANKISATQISLMREALKQLIAPDLDEKQSRRVPDGYQLSIFESENKDYQNLLAAEEVPIQPPKPGDKPPLPPVQTKKTSVIIRKYAEGDYSKLLEGATLKLAQIEGSGFQEKIFDSNKSGEKVELPNGTYVLSELKPPQGYRFATPITFKVAAGKVLIKNKEGQFVENQNKEIAEPYSVTAFNDFEEIGYLSDFNNYGKFYYAKNTNGTSQVVYCFNADLHSPPDSYDSGETINPDTSTMKEVKYTHTAGGDLFKYALRPRDTNPEDFLKHIKKVIEKGYKKKGDSYNGLTETQFRAATQLAIYYFTDSTDLKTLKTYNNGKGYHGFESVDEKTLAVTKELITYAQNGSAPQLTNLDFFVPNNSKYQSLIGTEYHPDDLVDVIRMEDKKQEVIPVTHSLTVKKTVVGELGDKTKGFQFELELKDKTGQPIVNTLKTNNQDLVAKDGKYSFNLKHGDTIRIEGLPTGYSYTLKETEAKDYIVTVDNKVSQEAQSASENVTADKEVTFENRKDLVPPTGLTTDGAIYLWLLLLVPLGLWVWLIGRKGLKND
>NZ_LS483414.1|WP_002987832.1|126168_126690_+|signal-peptidase-I
MTNYLNRLNENPLFKAFIRLVLKISIIGFLGYILFQYVFGVMIVNTNQMSPAVSAGDGVLYYRLTDRYHINDVVVYEVDNTLKVGRIAAQAGDEVSFTQEGGLLINGHPPEKEVPYLTYPHSSGPNFPYKVPTGTYFILNDYREERLDSRYYGALPINQIKGKISTLLRVRGI
>NZ_LS483414.1|WP_023611495.1|126711_127740_+|QVPTGV-class-sortase-B-protein-sorting-domain-containing-protein
MKKNKLLLATAILATALGTASLNQNVKAETAGVVSSGQLTIKKSITNFNDDTLLMPKTDYTFSVNPDSAATGTESNLPIKPGIAVNNQDIKVSYSNTDKTSGKEKQVVVDFMKVTFPSVGIYRYVVTENKGTAEGVTYDDTKWLVDVYVGNNEKGGLEPKYIVSKKGDSATKEPIQFNNSFETTSLKIEKKVTGNTGDHKKAFNFTLTLQPNEYYEASSVVKIEENGQTKDVKIGEAYKFTLNDSQSVILSKLPVGINYKVEEAEANQGGYTTTATLKDGEKLSTYNLGQEHKTDKTADEIVVTNKRDTQVPTGVVGTLAPFAVLSIVAIGGVIYITKRKKA
>NZ_LS483414.1|WP_030127390.1|127755_128481_+|class-B-sortase
MMMTIVQVINKAIDTLILIFCLVVLFLAGFGLWDSYHLYQQADASNFKKFKTAQQQPKFEDLLALNEDVIGWLNIPGTHIDYPLVQGKTNLEYINKAVDGSVAMSGSLFLDTRNHNDFTDDYSLIYGHHMAGNAMFGEIPKFLKKDFFNKHNKAIVETKERKKLTVTIFACLKTDAFDQLVFNPNAITNQDQQRQLVDYISKRSKQFKPVKLKHHTKFVAFSTCENFSTDNRVIVVGTIQE
>NZ_LS483414.1|WP_152539042.1|128497_129085_+|fimbrial-protein
MRKYWKMLFSVVMILTMLAFNQTVLAKDNTVQTSISVENVLERAGDSTPFSIALESIDAMKTIEEVTIAGSGKASFSPLTFTTVGQYTYRVYQKPSQNKDYQADTTVFDVLVYVTYDEDGTLVAKVISRRAGDEEKSAITFKPKRLVKPIPPRQPDIPKTPLPLAGEVKSLLGILSIVLLGLLVLLYVKKLKSRL
>NZ_LS483414.1|WP_111705974.1|129227_130433_-|YSIRK-targeted-surface-antigen-transcriptional-regulator
MVIFDLKYVQTLHSLSQLPISVMSQDKALIQVYGNDDYLLCYYQFLKHLAIPQAAQDVIFYEGLFEESFMIFPLCHYIIAIGPFYPYSLDKDYQEQLANNFLKHSSHRSKEELLSYMALVPHFPINNVRNLLIAIDAFFDTQFETTCQQTIHQLLQHSKQMTADPDIIHRLKHISKASSQLPPVLEHLNHIMDLVKLGNPQLLKQEINRIPLSSITSSSISALRAEKNLTVIYLTRLLEFSFVENTDVAKHYSLVKYYMALNEEASDLLKVLRIRCAAIIHFSESLTNKSISDKRQMYNSVLHYVDSHLYSKLKVSDIAKHLYVSESHLRSVFKKYSNVSLQHYILSTKIKEAQLLLKRGIPVGEVAKSLYFYDTTHFHKIFKKYTGISSKDYLAKYRDNI
>NZ_LS483414.1|WP_030127387.1|130817_134303_+|fibronectin-binding-protein
MTQKNSYKLSFLLSLTGFILGLLLVFIGLSGVSVGHAETRNGANKQGSFEIKKVDQNNNPLPRATFSLTPKDGKGTSVQTFTSNDKGIVDAQNLQPGTYTLKEDKAPDGYDKTSRTWTVTVYENGYTKLVENPYNGEIISKAGSKDVSQSLQLEKSTMSVVSKYGEQEKTSNSADFYRNHAAYFKMSFELKQKDKSETINPGDTFVLQLDQRLNPKGISQDIPKIIYDSANSPLAIGKYDAESHQLIYTFTDYIAGLDKVQLSAELSLFLENKEVLENTNISDFKSTIGGQEITYKGTVNVIYGNKSGDSNNYVTKGLSNVGGSIESYNTQTGDFTWYVYVNPNRTNIPYATMNLWGFGRARSNTNNLETNANTSSAELGEIQVYEVPDGEKLPSSYGVDVTKLTLRTDITAGLGDGFPMTKRQRIDFKDNLKDGKRFVVKITGKTDQSGKPLVVQSNLASFNDQSAVNSSKPTNNVYFQNEIALSPSKGSGSGTSEFTKPSITVANLKRVAQLRFKKMSTDNVPLPEAAFELRSSNGNSQKLEASSNTQGEVHFKDLNSGTYDLYEKQAPKGYQQVTEKLATVTVDTSKSAEQMVKWEKTHSSVKVEDSKEVTIVNHKETLTFSGKKIWENDRPDQRPAKIQVQLLQNGQKMSDKVQEVTKDNDWSYHFKDLPKYDGKNQEYKYSVEEVKVPDGYKVSYLGNDIFNTRETEFVFEQNNFNLEFGNAEIKGQSGSKIIDEDTLTSFKGKKIWKNDTAENRPQAIQVQLYADGVAVEGQTKFISGSGNEWSFEFKNLKKYNGTGNDIIYSVKEVTVPTGYDVTYSANDIINTKREVITQQGPKLEIEETLPLESGASGGTTTVEDSRPVDTLSGLSSEQGQSGDMTIEEDSATHIKFSKRDIDGKELAGATMELRDSSGKTISTWISDGQVKDFYLMPGKYTFVETAAPDGYEIATAITFTVNEQGQVTVNGKATKGDAHIVMVDAYKPTKGSGQVIDIEEKLPDEQGHSGSTTEIEDSKPSDVIIGGQGEVVDTTEDTQSGMTGHSGSTTEIEDSKSSDVIIGGQGQIVETTEDTQTGMHGDSGCKTEVEDTKLVQSFHFDNKESESNSEIPKKDKPKSNTSLPATGEKQHNMFFWMVTSCSLISSVFVISLKSKKRLSSC
>NZ_LS483414.1|WP_030127386.1|134569_135235_-|hypothetical-protein
MKRCNKYLFTSLLAASMLFSSYKSVHAHDNIDEKGKVHLYWQGNYYVDNYVDYTKKLVDNNNSIEWTVTFNSAKEQWVYPDFSVFLPKGVKAPTEITYEHHYWDGTVHSEKHNNTQWHYDWENQQTNFNQEFDKFPGYTGWSPSLDKFYKLKNDGKFSHVLVDTYGRQSHTYFSHKMVWKFKTELEEGNKDKWNKLPFIAGIKQNNPLAASFPSYKGEFGE
>NZ_LS483414.1|WP_030127385.1|135587_136994_+|short-chain-fatty-acid-transporter
MNNIKTKKRFMDRYIDGFMKWMPESLFICFILTFLVVTMSVLMTDSPFIGTEKTGGIIYGWVNGFWGLLSFAMQMTILLATGNAVASSPPAHKMFKSLAKLPQTRTQIFIFSIVVGSIFGFLHWGLGMMVAIVFGKELLVQARQKGIKVHTPLFVATLFFTFLPATSGLSGAAVLYSATPDYLRNSVADAYKQVVPESVPLTESVLNLPFISLLVVCMLVPLCFALLAHPKDETKIMELDDEIYHHSLDTASHVVIARNTPAEKMNASRLVMYLVGGAIVSYSLYHFSVVGLSGLDLNSFNFLFLGLGLLLCGQQGPEYYGSLFKDGVMSSWGLVLQFPFYAGIFGIIQSTGLGLEISHFFVAISNGTTWPVFAYLYSALLNIAVPSGGSKFVIEAPYIVPATIEVGNDLGKILQAYQLGDATTNLIVPFWALSYLSNFKLKFNQIVAYTIPCVLVVTGIAIIYLLVF

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Crispr_ID: NZ_LS483414_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LS483414_2

913431-913531

Orphan

Consensus_repeat	Method
TATAATTAGACTATACCAATTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_LS483414_2

>merge|NZ_LS483414|2|913431-913531|CRISPRCasFinder
TATAATTAGACTATACCAATTTTATGTTTGACAAGACATTGTGGATATTATATACTGTAAACATAATGTTTTTATCGGTATAATTAGACTATACCAATTAT

>NZ_LS483414|2|1|913431-913531|CRISPRCasFinder
TATAATTAGACTATACCAATTTT	ATGTTTGACAAGACATTGTGGATATTATATACTGTAAACATAATGTTTTTATCGG
TATAATTAGACTATACCAATTAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LS483414.1\|WP_030127227.1\|925566_925815_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl\|CDD\|225170
NZ_LS483414.1\|WP_002989626.1\|915592_915928_+\|alkylphosphonate-utilization-protein	unknown	unknown	gnl\|CDD\|225380
NZ_LS483414.1\|WP_020905235.1\|917330_918167_+\|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270217
NZ_LS483414.1\|WP_002984451.1\|913582_915397_+\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NZ_LS483414.1\|WP_002984433.1\|904815_905601_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LS483414.1\|WP_002989607.1\|904070_904685_+\|TVP38/TMEM64-family-protein	unknown	unknown	gnl\|CDD\|223475
NZ_LS483414.1\|WP_030127221.1\|906863_909974_+\|DNA-polymerase-III-subunit-alpha	unknown	unknown	gnl\|CDD\|180917
NZ_LS483414.1\|WP_030127222.1\|911129_912632_+\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|235619
NZ_LS483414.1\|WP_030127223.1\|912849_913407_+\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NZ_LS483414.1\|WP_002984437.1\|905610_906309_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_LS483414.1\|WP_030127226.1\|922885_925204_+\|DNA-helicase-PcrA	unknown	unknown	gnl\|CDD\|273429
NZ_LS483414.1\|WP_011054546.1\|903291_903480_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|269889
NZ_LS483414.1\|WP_030127225.1\|919678_920914_-\|cation-diffusion-facilitator-family-transporter	unknown	unknown	gnl\|CDD\|223131
NZ_LS483414.1\|WP_002992407.1\|921033_922356_-\|sodium:alanine-symporter-family-protein	unknown	unknown	gnl\|CDD\|224040
NZ_LS483414.1\|WP_030127224.1\|918535_919309_+\|CAMP-factor-pore-forming-toxin-Cfa	unknown	unknown	gnl\|CDD\|369335
NZ_LS483414.1\|WP_002989617.1\|906308_906680_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224639
NZ_LS483414.1\|WP_002992415.1\|916685_917315_+\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_LS483414.1\|WP_002992417.1\|916034_916676_+\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NZ_LS483414.1\|WP_020833516.1\|902392_903181_+\|streptococcal-pyrogenic-exotoxin-SpeL	unknown	unknown	gnl\|CDD\|280949
NZ_LS483414.1\|WP_002984444.1\|910053_911067_+\|6-phosphofructokinase	unknown	unknown	gnl\|CDD\|235111

Protein	Function_ID	Function_description	E-value
NZ_LS483414.1\|WP_030127227.1\|925566_925815_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl\|CDD\|225170	COG2261, COG2261, Predicted membrane protein [Function unknown].	6.94105e-14
NZ_LS483414.1\|WP_002989626.1\|915592_915928_+\|alkylphosphonate-utilization-protein	gnl\|CDD\|225380	COG2824, PhnA, Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism].	2.02984e-64
NZ_LS483414.1\|WP_020905235.1\|917330_918167_+\|amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270217	cd00996, PBP2_AatB_like, Polar amino acids-binding domain of ATP-binding cassette transporter-like systems that belong to the type 2 periplasmic binding fold protein superfamily. This subfamily includes periplasmic binding domain of ATP-binding cassette transporter-like systems that serve as initial receptors in the ABC transport of amino acids and their derivatives in eubacteria. After binding their ligand with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically-located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The Abp proteins belong to the PBPI superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.15422e-109
NZ_LS483414.1\|WP_002984451.1\|913582_915397_+\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NZ_LS483414.1\|WP_020833516.1\|902392_903181_+\|streptococcal-pyrogenic-exotoxin-SpeL	gnl\|CDD\|280949	pfam02876, Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain.	2.95713e-08
NZ_LS483414.1\|WP_002989607.1\|904070_904685_+\|TVP38/TMEM64-family-protein	gnl\|CDD\|223475	COG0398, COG0398, Uncharacterized conserved protein [Function unknown].	1.14841e-31
NZ_LS483414.1\|WP_030127221.1\|906863_909974_+\|DNA-polymerase-III-subunit-alpha	gnl\|CDD\|180917	PRK07279, dnaE, DNA polymerase III DnaE; Reviewed.	0
NZ_LS483414.1\|WP_030127222.1\|911129_912632_+\|pyruvate-kinase	gnl\|CDD\|235619	PRK05826, PRK05826, pyruvate kinase; Provisional.	0
NZ_LS483414.1\|WP_030127223.1\|912849_913407_+\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	1.75321e-38
NZ_LS483414.1\|WP_002984437.1\|905610_906309_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	7.28377e-64
NZ_LS483414.1\|WP_030127226.1\|922885_925204_+\|DNA-helicase-PcrA	gnl\|CDD\|273429	TIGR01073, ATP-dependent_DNA_helicase_PcrA, ATP-dependent DNA helicase PcrA. Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_LS483414.1\|WP_011054546.1\|903291_903480_+\|hypothetical-protein	gnl\|CDD\|269889	cd06603, GH31_GANC_GANAB_alpha, neutral alpha-glucosidase C, neutral alpha-glucosidase AB. This subgroup includes the closely related glycosyl hydrolase family 31 (GH31) isozymes, neutral alpha-glucosidase C (GANC) and the alpha subunit of heterodimeric neutral alpha-glucosidase AB (GANAB). Initially distinguished on the basis of differences in electrophoretic mobility in starch gel, GANC and GANAB have been shown to have other differences, including those of substrate specificity. GANC and GANAB are key enzymes in glycogen metabolism that hydrolyze terminal, non-reducing 1,4-linked alpha-D-glucose residues from glycogen in the endoplasmic reticulum. The GANC/GANAB family includes the alpha-glucosidase II (ModA) from Dictyostelium discoideum as well as the alpha-glucosidase II (GLS2, or ROT2 - Reversal of TOR2 lethality protein 2) from Saccharomyces cerevisiae.	0.00788697
NZ_LS483414.1\|WP_030127225.1\|919678_920914_-\|cation-diffusion-facilitator-family-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	5.69788e-95
NZ_LS483414.1\|WP_002992407.1\|921033_922356_-\|sodium:alanine-symporter-family-protein	gnl\|CDD\|224040	COG1115, AlsT, Na+/alanine symporter [Amino acid transport and metabolism].	0
NZ_LS483414.1\|WP_030127224.1\|918535_919309_+\|CAMP-factor-pore-forming-toxin-Cfa	gnl\|CDD\|369335	pfam07373, CAMP_factor, CAMP factor (Cfa). This family consists of several bacterial CAMP factor (Cfa) proteins which seem to be specific to Streptococcus species. The CAMP reaction is a synergistic lysis of erythrocytes by the interaction of an extracellular protein (CAMP factor) produced by some streptococcal species with the Staphylococcus aureus sphingomyelinase C (beta-toxin).	3.33966e-97
NZ_LS483414.1\|WP_002989617.1\|906308_906680_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224639	COG1725, COG1725, Predicted transcriptional regulators [Transcription].	4.0536e-49
NZ_LS483414.1\|WP_002992415.1\|916685_917315_+\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	5.61041e-111
NZ_LS483414.1\|WP_002992417.1\|916034_916676_+\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	2.99371e-71
NZ_LS483414.1\|WP_002984444.1\|910053_911067_+\|6-phosphofructokinase	gnl\|CDD\|235111	PRK03202, PRK03202, ATP-dependent 6-phosphofructokinase.	0

>NZ_LS483414.1|WP_030127223.1|912849_913407_+|signal-peptidase-I
MVKRDFIRNILLLLIVIIGAILLRIFVFSTFKVSPETANTYLKSGDLVTIKKNIQPKYKDFVVYRVGKKDYVSRVIAVEGDSVTYMDDIFYLNNMVESQAYLEKMKAHYLNHAPFGTLYTDDFTVATITADKYQKVPKGKYLLLNDNRKNTKDSRRFGLINASQIKGLVTFRVLPLSDFGFVEVE
>NZ_LS483414.1|WP_030127222.1|911129_912632_+|pyruvate-kinase
MNKRVKIVATLGPAVEIRGGKKYGEDGYWAGQLDVEESAKKIAELIEAGANVFRFNFSHGDHKEQGDRMATVRLAEEIARQKVGFLLDTKGPEMRTELFADDAKEFSYVTGEKIRVAATQGIQSTRDVIALNVAGSLDIYDEVEVGHTILIDDGKLGLKVIDKDIATRQFIVEVENDGIIAKQKGVNIPNTKIPFPALAERDNADIRFGLEQGLNFIAISFVRTAKDVEEVREICRETGNDHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVFQKMIITKVNAAGKAVITATNMLETMTEKPRATRSEVSDVFNAVIDGTDATMLSGESANGKYPVESVRTMATIDRNAQTLLNEYGRLDSSAFPRTNKTDVIASAVKDATHSMDIKLVVTITETGNTARAISKFRPDADILAVTFDEKVQRALMINWGVIPVLAEKPASTDDMFEVAERVAVEAGLVQSGDNIVIVAGVPVGTGGTNTMRVRTVK
>NZ_LS483414.1|WP_002984444.1|910053_911067_+|6-phosphofructokinase
MKRIAVLTSGGDAPGMNAAIRAVVRKAISEGMEVYGINRGYAGMVDGDIFPLGSKEVGDKISRGGTFLYSARYPEFAQLEGQLAGIEQLKKHGIEGVVVIGGDGSYHGAMRLTEHGFPAVGIPGTIDNDIAGTDYTIGFDTAVNTAVEAIDKLRDTSSSHGRTFVVEVMGRNAGDIALWAGIASGADQIIVPEEEFDIEKVASTIQYDFEHKGKNHHIIVLAEGVMSGEAFAQKLKEAGDKSDLRVTNLGHILRGGSPTARDRVIASWMGSHAVELLKEGKGGLAVGIHNEELVESPILGTAEEGALFSLTEEGKIIVNNPHKARLDFAALNRSLSQ
>NZ_LS483414.1|WP_030127221.1|906863_909974_+|DNA-polymerase-III-subunit-alpha
MFAQLDTKTVYSFMDSLIDLNHYFERAKQFGYHTIGIMDKDNLYGAYHFIKGCQKNGLQPVLGLEVEILYQERQVLLNLIAQNTQGYHQLLKISTAKMSGKLHMDYLCQHLEGIAVIIPSKGWSDTLVVPFDYYIGVDQYTDLSHMDSKRQLIPLRTVRYFAQDDMETLHMLHAIRDNLSLAETPVVESDQELADCQQLTTFYQTHCPQALQNLEDLVSGIYYDFDTNLKLPHFNRDKSAKQELQELTEAGLKEKGLWKEPYQSRLLHELVIISDMGFDDYFLIVWDLLRFGRSKGYYMGMGRGSAAGSLVAYALNITGIDPVQHDLLFERFLNKERYSMPDIDIDLPDIYRSEFLRYVRNRYGSDHSAQIVTFSTFGPKQVIRDVFKRFGVPEYELTNLTKKIGFKDSLATVYEKSISFRQVINSRTEFQKAFAIAKRIEGNPRQTSIHAAGIVMSDDTLTNHIPLKSGDDMMITQYDAHAVEANGLLKMDFLGLRNLTFVQKMQEKVAKDYGCQIDIAAIDLEDPQTLALFAKGDTKGIFQFEQNGAINLLKRIKPQRFEEIVATTSLNRPGASDYTTNFIKRREGQEKIDLIDPVIAPILEPTYGIMLYQEQVMQIAQVYAGFTLGKADLLRRAMSKKNLQEMQKMEEDFIASAKHLGRAEETARGLFKRMEKFAGYGFNRSHAFAYSALAFQLAYFKAHYPAVFYDIMMNYSSSDYITDALESDFQVAQVTINSIPYTDKIEASKIYMGLKNIKGLPRDFAYWIIEQRPFNSVEDFLTRTPEKYQKKVFLEPLIKIGLFDCFEPNRKKILDNLDGLLVFVNELGSLFSDSSFSWVDAKDYSATEKYSLEQEIVGVGMSKHPLIDIAEKSTQTFTPISQLVKESEAVVLIQIDSIRIIRTKISGQQMAFLSVNDTKKKLDVTLFPQEYAIYKDQLKEGEFYYLKGRIKERDHRLQMVCQQVQMAISQKYWLLVENHQFDSQISEILGAFPGTTPVVIHYQKNKETIALTKIQVHVTENLKEKLRPFVLKTVFR
>NZ_LS483414.1|WP_002989617.1|906308_906680_-|GntR-family-transcriptional-regulator
MSWKFDEKSPIYAQIAQHVMMQIISQEIKSGDQLPTVREYAEIAGVNPNTMQRAFTELEREGMVYSQRTAGRFVTDDQKLIARKRRELAISELESFITNMTKMGFSHTEIIPVLTSFLKEDSQ
>NZ_LS483414.1|WP_002984437.1|905610_906309_-|ABC-transporter-ATP-binding-protein
MAHLLQLHHVSKSYREKKAIDDLTITIPNGKIIGLLGPNGSGKTTLIKLINGLLQPNKGEIVIDGYRPCVETKKIISYLPDTTYLNENMRIKDMLEFFSDFYSDFDKSKATSLLRDLELDPEDRFKTLSKGNKEKVQLILVMSRKARLYVLDEPIGGVDPAARDYILKTIINSYCENASVIISTHLISDIEPILDEVIFLKQGRLFLSGNADDLRQEYQQSIDSLFRETYKV
>NZ_LS483414.1|WP_002984433.1|904815_905601_-|hypothetical-protein
MFGKLLKYEFRSIGKWYFALNAFVIAIAAILSFTIKLFAQSNSDGLFGVLTNKMLPLTLGLTFGSLIAGSLLSTLLIIIKRFSKSVFGREGYLTLTLPVNSHQIILSKLLASFICSVFNTIILAFAIAIVIVPMFNINELLEGFFNSFKMDYFINMLTVLAYVLLSTFTSILLIYLSISIGQLFSNRRGLMAFIAYFILVILISVAATYVHSHIFNINTSADSFPFTEQKTIYLLILEQFIEMIMFYLATNFIIKNKLNLQ
>NZ_LS483414.1|WP_002989607.1|904070_904685_+|TVP38/TMEM64-family-protein
MTKRNSKAYILWQKIIKILGIIALIGTFFLAFWLYRLGILNDSNALKDLVQRYRLWGPFVFIVVQIIQIVFPVIPGGLTTVAGFLIFGPVTGFIYNYVGIIIGSIVLFLLVKTYGRKFILLFVNDKTFYKYERRLETPGYEKLFIFCMASPVSPADIMVMITGLTDMSLKRFVTILLITKPISIIGYSYLFIFGKDVISWFLQH
>NZ_LS483414.1|WP_011054546.1|903291_903480_+|hypothetical-protein
MLTYDEFKQAIDDGYIVGDTVMIVRKNGQIFDYVLPHEEARNGEVVTEEKVEEVMVELDYIK
>NZ_LS483414.1|WP_020833516.1|902392_903181_+|streptococcal-pyrogenic-exotoxin-SpeL
MRIFLHQNCRLVNMSTTFFIVVLSLMVFSVRMVSAEGTINIKDIYPPRWDVDKTLSPTTLREIYNRDTIKKVNKPITGKRGTQVIMDAQHKTKVWEFDDYNFIISSNLHPSVEGKFNVGDNVDVFGLALSAEVFSKDQIHSINGGLVKVNERKGAGKTIYMNVFIDGHKKDDTSKYKITFEKSPVTFQEVDVRLRKSFMLNDEIKLYQYDSKVLSGNWEFHGSGEKEEGADLFKYPDYRYNNLIDIDKKSHIDVYLFTNKEN
>NZ_LS483414.1|WP_002984451.1|913582_915397_+|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGVVGNRNATDILMQGLEKLEYRGYDSAGIFVANANQTNLIKSVGRIADLRAKIGIDVAGSTGIGHTRWATHGQSTEDNAHPHTSQTGRFVLVHNGVIENYLHIKTEFLAGHDFKGQTDTEIAVHLIGKFVEEDKLSVLEAFKKALSIIEGSYAFALMDSQATDTIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVILTKDKVTVTDYDGKELIRDSYTAELDLSDIGKGTYPFYMLKEIDEQPTVMRQLISTYADETGNVQVDPAIITSIQEADRLYILAAGTSYHAGFATKNMLEQLTDTPVELGVASEWGYHMPLLSKKPMFILLSQSGETADSRQVLVKANAMGIPSLTVTNVPGSTLSRESTYTMLIHAGPEIAVASTKAYTAQIAALAFLAKAVGEANGKQEALDFNLVHELSLVAQSIEATLSEKDLVAEKVQALLTTTRNAFYIGRGNDYYVAMEAALKLKEISYIQCEGFAAGELKHGTISLIEEDTPVIALISSSQLVASHTRGNIQEVAARGAHVLTVVEEGLDREGDDIIVNKVHPFLAPIAMVIPTQLIAYYASLQRGLDVDKPRNLAKAVTVE
>NZ_LS483414.1|WP_002989626.1|915592_915928_+|alkylphosphonate-utilization-protein
MSLPNCLQCQSEYVYEDGLLLICPMCAFEWTPGEEATEEEGLVVLDSNGVRLSDGDTITVVKDLKVKGAPKDLKQGTRVKNIRLVEGDHNIDCKIDGFGAMKLKSEFVKKI
>NZ_LS483414.1|WP_002992417.1|916034_916676_+|amino-acid-ABC-transporter-permease
MTYIQQVLPSLLDGALVTLQVFFIVIILSIPLGAILAFLMKIPFKPLQWFLTLYVWMMRGTPLLLQLIFFYYVLPSVGISFDRMPAAILAFTLNYAAYFAEIFRGGIEAIPKGQYEAAKVLKLKPLQTIRYIILPQVFKIVLPSVFNEVINLVKDSSLVYVLGVGDLLLASKTAANRDATLAPMFIAGLIYLLLIGLVTIISKQVEKRFNYYQ
>NZ_LS483414.1|WP_002992415.1|916685_917315_+|amino-acid-ABC-transporter-ATP-binding-protein
MLELKNISKQFGQKTIFDGFNLTVQDGEVLSLVGPSGGGKTTLLRMLAGLESIDSGQVFYNGEDVGIDHLENRNLLGFVFQDFQLFPHLTVLDNLTLSPTITMGKQKSDAKEKALDLLARLGLKEHAQVYPYSLSGGQKQRVALARAMMIDPQIIGYDEPTSALDPELRQTVEALIVQNREMGITQIVVTHDLVFAEAISDRIIRVNPK
>NZ_LS483414.1|WP_020905235.1|917330_918167_+|amino-acid-ABC-transporter-substrate-binding-protein
MIIKKRTVAILAIASSFFLVACQATKSLKSGDAWGVYQKQKSITVGFDNTFVPMGYKDESGKCKGFDIDLAKEVFHQYGLKVNFQAINWDMKEAELNNGKIDVIWNGYSITKERQDKVAFTDSYMRNEQIIVVKKRSDIKTISDMKHKVLGAQSASSGYDALLRTPKLLKDFIKNKDANQYETFTQAFIDLKSDRIDGILIDKVYANYYLAKEGQLENYRMIPTTFENEAFSVGLRKEDKTLQAKINRAFRVLYQNGKFQAISEKWFGDDVATANIKS
>NZ_LS483414.1|WP_030127224.1|918535_919309_+|CAMP-factor-pore-forming-toxin-Cfa
MKPKHLLCLSTVVAGLALFSTMTHSVLADDASNPDTILMNNNQANLQRDALVEKLDEGHQQLEAIKHEAKGTDIEATINKAIDAVDHMKSSIRFNTETIYDFSSIGARVEALSDAIKAIVFSTTQLTHKVEKAHTDMGFAITKLVIRIIDPFASVDAIKAQVQEIKALEEKVINYPDLQPTDRATIYTKAKLNKAIWNTRLERDKKVLGIKSFDVYNRLNKAITHAVGVQLNPTTTVQQVDDEVIAVQNALETALKS
>NZ_LS483414.1|WP_030127225.1|919678_920914_-|cation-diffusion-facilitator-family-transporter
MTLDPIANLKLARKGPIVSIIVYLLLSAAKLLAGYLLNASSLIADGFNNLSDIVGNVALLIGLHLASQPADANHKFGHWKIEDLSSLVTSFIMFLVGFQVLIHTIKSIFSGQQVDIDPLGAIVGIVSAFVMLGVYVFNKRLSKRVKSSALVAASKDNLADAVTSIGTSIAIIAASLHLPVIDHIAAMIITFFILKTAFDIFMESSFSLSDGFDSRHLKKYEKAILEIPKIVAVKSQRARTYGSNVYLDIVLEMNPDLSVYESHSITEKVEQLLSDQFSIYDIDIHVEPAMILEEEIFDNVAKKLYRYEKLILSKVPDYDHYIAKSFQLVDANGQTVNYEQFLNQEIYYPSNFNHFQIESISQKTMLVTYQLNGNQHTSIWRRHESWSLLFHQITPIAKRQLHPTHYRIVKM
>NZ_LS483414.1|WP_002992407.1|921033_922356_-|sodium:alanine-symporter-family-protein
MIALVKLIDNLVWGPPLLILLVGTGIYLTSRLGLIQILKLPRAFKLIFSDDEGHGDISSFAALATALAATVGTGNIVGVATAIKSGGPGALFWMWVAAFFGMATKYAEGVLAIKYRTKDANGHISGGPMYYIVNGMGTKWKPLAILFAGSGILVALFGIGTFAQVNSITSSLGHSFGLSPQMVSIVLAIFVAAIIFGGIHSISKVAEKVVPFMAIFYILSSLAVIFSHYQQLLPVIRLVFQSAFTPTAAIGGFAGSLMKDAIQKGIARGVFSNESGLGSAPIAAAAAKTNEPVEQGLISMTGTFIDTIIICTLTGLSILVTGQWTGQLEGAPLTQSAFATVFGNLGTFGLTFSLVLFAFTTILGWSYYGERCFEFLFGITHLTYFRIVFVLMVGLGGFLKLELIWVLADIVNGLMALPNLIALLALSPVVILETKHYFIK
>NZ_LS483414.1|WP_030127226.1|922885_925204_+|DNA-helicase-PcrA
MNPLLNGMNDRQAQAVQTTEGPLLIMAGAGSGKTRVLTHRIAYLIDEKFVNPWNILAITFTNKAAREMKERALALNPATKDTLIATFHSMCVRILRREADHIGYNRNFTIVDPGEQRTLMKRILKQLNIDPKKWNERSILGTISNAKNDLLDEKGYEAQAADMYSQIVARCYKAYQEELRRSEALDFDDLIMMTLRLFDANPDVLAYYQQRYQYIHVDEYQDTNHAQYQLIKLLASRFKNICVVGDADQSIYGWRGADMQNILDFEKDYPDAKVVLLEENYRSTKKILQAANDVINNNRNRRPKKLWTQNADGEQLVYYRANDERDEAVFVASTISNMSQELGKNFKDFAVLYRTNAQSRTIEEALLKSNIPYTMVGGTKFYSRKEIRDLIAYLTIVANPADNISFERIVNEPKRGVGPGTLDKLRQFAYESDQSLLEAASNLLMSPLKGKAAQAIMDLANILGQLRQDLDQMSITDLAEALLEKTGYLDSLRLQNTLESQARIENIEEFLSVTKNFDESSASQEEDETGVDRLGRFLNDLALIADTDDSQAEAAEVTLMTLHAAKGLEFPVVFLIGMEEGVFPLSRASEDPDELEEERRLAYVGITRAEEVLFMTNANTRTLFGKSSYNRPTRFLKEISEELLSYKGLARPAQSSFGVRFSTETHTQFGQGMSLSEALQARKAQAQVRQSVQPMQAHTIPSVSTSSVLPFGSNSSVEEVTWQIGDIAHHKKWGDGTVLEVSGSGKTMELKIKFPEVGLKKLLASVAPIEKK
>NZ_LS483414.1|WP_030127227.1|925566_925815_+|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MGLIWTLIVGALIGVIAGALTKKSGSMGWIANIAAGLVGSSVGQALLGSWGPSLAGMSLIPSVIGAVIVVMITSFVLNKTNN

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_LS483414_1	1.2\|121662\|21\|NZ_LS483414\|PILER-CR	121662-121682	21	NZ_LS483414.1	121713-121733	1	0.952

1. spacer 1.2|121662|21|NZ_LS483414|PILER-CR matches to position: 121713-121733, mismatch: 1, identity: 0.952

tgcgcttcccccattaatgcc	CRISPR spacer
tgcgcttcctccattaatgcc	Protospacer
*********.***********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

38904 : 51289

Synechococcus_phage(28.57%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_030127614.1\|38904_42630_+	phosphoribosylformylglycinamidine synthase	A6N228	Microbacterium_phage	6.0e-40	27.0
WP_030127615.1\|42863_44318_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	8.3e-54	32.7
WP_002987707.1\|44345_45368_+	phosphoribosylformylglycinamidine cyclo-ligase	R9TMC7	Synechococcus_phage	4.0e-63	41.8
WP_002986700.1\|45535_46090_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	2.4e-25	36.1
WP_030127616.1\|46273_47821_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	E3SNU8	Prochlorococcus_phage	3.4e-45	52.4
WP_030127617.1\|47877_49002_-	SH3 domain-containing protein	F8HGP2	Streptococcus_phage	7.7e-07	28.6
WP_030127618.1\|49254_50520_+	phosphoribosylamine--glycine ligase	NA	NA	NA	NA
WP_030127619.1\|50797_51289_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	2.5e-18	42.3

DBSCAN-SWA_2

604266 : 703907

110

Streptococcus_phage(55.38%)

terminase,integrase,holin,tail,capsid,head,tRNA,portal,protease

attL 622102:622117|attR 660974:660989

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_030127413.1\|604266_607068_+\|tRNA	isoleucine--tRNA ligase	H2EEZ0	Moumouvirus	5.5e-70	26.9
WP_002983878.1\|607332_607635_-	DUF1827 family protein	NA	NA	NA	NA
WP_002989103.1\|607685_608141_-	NUDIX hydrolase	NA	NA	NA	NA
WP_002983882.1\|608268_610551_-\|protease	ATP-dependent Clp protease ATP-binding subunit	A0A2C9CYX3	Yersinia_phage	1.1e-124	39.6
WP_002983885.1\|610847_611078_+	YkuJ family protein	NA	NA	NA	NA
WP_030127414.1\|611204_611891_+	amino acid ABC transporter permease	NA	NA	NA	NA
WP_011017999.1\|611890_612625_+	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.6e-34	38.8
WP_030127415.1\|612773_614183_+	deoxyribodipyrimidine photo-lyase	A0A1V0SGL1	Hokovirus	3.4e-60	32.6
WP_002989112.1\|614360_616055_+	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	1.6e-128	42.4
WP_002989114.1\|616262_617117_+	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase	A0A249XZQ2	Enterococcus_phage	4.4e-39	39.4
WP_030127416.1\|617269_618610_+	exodeoxyribonuclease VII large subunit	A0A1V0SIT1	Klosneuvirus	6.3e-40	31.2
WP_030127417.1\|618587_618803_+	exodeoxyribonuclease VII small subunit	NA	NA	NA	NA
WP_023612801.1\|618802_619675_+	polyprenyl synthetase family protein	NA	NA	NA	NA
WP_030127418.1\|619667_620495_+	TlyA family RNA methyltransferase	NA	NA	NA	NA
WP_002983907.1\|620481_620952_+	arginine repressor	NA	NA	NA	NA
WP_011017995.1\|620972_622634_+	DNA repair protein RecN	NA	NA	NA	NA
622102:622117	attL	NA	NA	NA	NA
WP_023605175.1\|622805_623744_+	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_030127419.1\|623959_624811_+	DegV family protein	A0A0N9SI50	Staphylococcus_phage	5.4e-13	35.7
WP_002992620.1\|624803_625646_+	SGNH/GDSL hydrolase family protein	NA	NA	NA	NA
WP_002989129.1\|625623_626211_+	YpmS family protein	NA	NA	NA	NA
WP_002983920.1\|626309_626585_+	HU family DNA-binding protein	A7KV42	Bacillus_phage	2.6e-25	73.0
WP_003051793.1\|626674_627817_-\|integrase	site-specific integrase	M1NRJ9	Streptococcus_phage	2.4e-173	77.4
WP_030127420.1\|627953_628634_-	hypothetical protein	A0A097PAS7	Streptococcus_pyogenes_phage	1.2e-74	87.7
WP_030127421.1\|628668_629427_-	helix-turn-helix domain-containing protein	A0A097PBE5	Streptococcus_pyogenes_phage	3.1e-84	65.9
WP_076636802.1\|629816_629975_+	hypothetical protein	A0A097PAP2	Streptococcus_pyogenes_phage	1.1e-23	98.1
WP_030127422.1\|630005_630605_-	hypothetical protein	A0A097PAT4	Streptococcus_pyogenes_phage	9.1e-108	99.5
WP_021340823.1\|630659_630806_+	hypothetical protein	NA	NA	NA	NA
WP_050429000.1\|630802_631309_-	hypothetical protein	NA	NA	NA	NA
WP_001157159.1\|631358_631565_+	helix-turn-helix domain-containing protein	A0A1X9I5S3	Streptococcus_phage	1.1e-17	64.7
WP_002984292.1\|631810_632020_-	hypothetical protein	NA	NA	NA	NA
WP_011284879.1\|632169_632409_-	hypothetical protein	NA	NA	NA	NA
WP_011054585.1\|632575_632761_+	helix-turn-helix transcriptional regulator	A0A1X9I6I3	Streptococcus_phage	3.3e-16	72.1
WP_014411880.1\|632839_633151_+	hypothetical protein	A0A1S5SA25	Streptococcus_phage	1.4e-43	78.6
WP_023611037.1\|633152_633323_+	hypothetical protein	A7J273	Streptococcus_phage	2.9e-19	87.5
WP_030127424.1\|633315_633519_+	hypothetical protein	NA	NA	NA	NA
WP_030127425.1\|633515_633902_+	hypothetical protein	A7J274	Streptococcus_phage	6.8e-56	87.4
WP_017647437.1\|633898_634051_+	hypothetical protein	A7J275	Streptococcus_phage	9.9e-19	98.0
WP_030127426.1\|634047_634251_+	hypothetical protein	A7J276	Streptococcus_phage	3.7e-29	89.6
WP_111705986.1\|634338_634638_+	hypothetical protein	A7J277	Streptococcus_phage	5.6e-42	98.0
WP_011888943.1\|634637_635795_+	DUF2800 domain-containing protein	A7J278	Streptococcus_phage	1.0e-216	98.2
WP_086934854.1\|635803_636367_+	DUF2815 family protein	D2J040	Enterococcus_phage	3.3e-51	58.5
WP_111705987.1\|636409_638332_+	DNA polymerase	A7J280	Streptococcus_phage	0.0e+00	98.9
WP_111705988.1\|638336_640721_+	DNA primase	A7J282	Streptococcus_phage	8.2e-277	94.6
WP_023613183.1\|641106_641382_+	VRR-NUC domain-containing protein	A7J283	Streptococcus_phage	1.3e-45	97.8
WP_111705989.1\|641378_642701_+	DEAD/DEAH box helicase family protein	A7J284	Streptococcus_phage	1.4e-249	97.0
WP_164972002.1\|642701_642872_+	hypothetical protein	A7J285	Streptococcus_phage	9.0e-21	92.3
WP_011054882.1\|642864_643137_+	hypothetical protein	A7J287	Streptococcus_phage	5.7e-25	73.3
WP_023079210.1\|643139_643286_+	hypothetical protein	NA	NA	NA	NA
WP_011054881.1\|643269_643686_+	transcriptional regulator	A7J289	Streptococcus_phage	3.3e-72	99.3
WP_030127432.1\|643775_644228_+\|terminase	terminase small subunit	A7J290	Streptococcus_phage	1.7e-66	95.7
WP_014635515.1\|644205_645513_+\|terminase	PBSX family phage terminase large subunit	A0A2H4IYR5	uncultured_Caudovirales_phage	2.9e-183	75.0
WP_032461297.1\|645524_647015_+\|portal	phage portal protein	C9W9H5	Streptococcus_virus	1.3e-142	54.0
WP_030127434.1\|646995_647910_+\|capsid	minor capsid protein	A1EAE3	Streptococcus_phage	1.3e-73	50.0
WP_030127435.1\|647925_648192_+	hypothetical protein	A0A097PAR8	Streptococcus_pyogenes_phage	4.1e-28	77.3
WP_030127436.1\|648335_648869_+	DUF4355 domain-containing protein	A0A141E0S7	Streptococcus_phage	1.8e-14	82.5
WP_002990036.1\|648878_649259_+	structural protein	A0A0K2CNR0	Brevibacillus_phage	6.4e-06	36.3
WP_030127437.1\|649261_650311_+\|capsid	major capsid protein	A0A286QR01	Streptococcus_phage	1.8e-106	57.7
WP_030127438.1\|650322_650589_+	hypothetical protein	NA	NA	NA	NA
WP_030127439.1\|650600_650954_+\|head,tail	phage head-tail connector protein	A0A2H4J002	uncultured_Caudovirales_phage	3.9e-26	52.1
WP_111705990.1\|650950_651235_+	hypothetical protein	A0A1P8BKV3	Lactococcus_phage	5.1e-08	36.6
WP_030127441.1\|651246_651603_+	HK97 gp10 family phage protein	A1EAF2	Streptococcus_phage	4.7e-19	44.0
WP_030127442.1\|651599_651998_+	DUF3168 domain-containing protein	A1EAF3	Streptococcus_phage	3.8e-25	44.5
WP_030127443.1\|651985_652504_+\|tail	phage major tail protein, TP901-1 family	A1EAF4	Streptococcus_phage	2.2e-41	51.7
WP_030127444.1\|652557_652926_+	hypothetical protein	NA	NA	NA	NA
WP_030127445.1\|652946_653264_+	hypothetical protein	A1EAF6	Streptococcus_phage	6.9e-14	44.4
WP_080279311.1\|653260_656011_+\|tail	phage tail tape measure protein	J7KDT4	Streptococcus_phage	1.9e-54	36.4
WP_030127447.1\|656010_656781_+\|tail	phage tail family protein	A1EAB1	Streptococcus_phage	1.2e-56	45.0
WP_111705991.1\|656777_658889_+\|tail	phage tail protein	A3F656	Streptococcus_phage	3.8e-132	43.1
WP_011284843.1\|658885_660100_+	hypothetical protein	A3F657	Streptococcus_phage	5.0e-44	49.5
WP_011284842.1\|660086_660416_+	hypothetical protein	NA	NA	NA	NA
WP_111705992.1\|660426_662316_+	gp58-like family protein	Q938J9	Temperate_phage	6.7e-189	75.7
660974:660989	attR	NA	NA	NA	NA
WP_002988448.1\|662327_662756_+	DUF1617 family protein	Q938J8	Temperate_phage	8.1e-58	84.3
WP_011054443.1\|662758_663391_+	hypothetical protein	Q938J7	Temperate_phage	2.0e-44	49.5
WP_011017397.1\|663402_663675_+	hypothetical protein	A7J2B2	Streptococcus_phage	5.5e-36	91.0
WP_011054444.1\|663671_663899_+\|holin	phage holin	A7J2B3	Streptococcus_phage	7.6e-31	98.7
WP_011054445.1\|664014_665223_+	glucosaminidase domain-containing protein	Q938J4	Temperate_phage	2.9e-214	87.5
WP_050440680.1\|665332_666319_-	DNA/RNA non-specific endonuclease	A7J2B8	Streptococcus_phage	5.2e-169	99.7
WP_030127450.1\|666551_666731_+	hypothetical protein	A3F673	Streptococcus_phage	3.4e-18	77.6
WP_011284646.1\|667565_668135_+	hydrolase	NA	NA	NA	NA
WP_002994058.1\|668135_670088_+	DNA topoisomerase (ATP-hydrolyzing) subunit B	G3M9Z3	Bacillus_virus	8.9e-144	46.3
WP_011017601.1\|670455_672180_+	septation ring formation regulator EzrA	NA	NA	NA	NA
WP_002990451.1\|672311_672770_-	YueI family protein	W6LLD2	Streptococcus_phage	1.8e-18	39.1
WP_002985288.1\|672999_674307_+	phosphopyruvate hydratase	A0A1X9I5Z8	Streptococcus_phage	1.2e-240	96.6
WP_002985285.1\|674981_675143_+	TOMM family cytolysin streptolysin S	NA	NA	NA	NA
WP_030127451.1\|675364_676315_+	streptolysin S biosynthesis dehydrogenase SagB	NA	NA	NA	NA
WP_002985275.1\|676311_677370_+	streptolysin associated protein SagC	NA	NA	NA	NA
WP_002990434.1\|677389_678748_+	YcaO-like family protein	NA	NA	NA	NA
WP_011054325.1\|678722_679394_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_002985270.1\|679390_680074_+	hypothetical protein	NA	NA	NA	NA
WP_002990429.1\|680096_681020_+	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	6.7e-33	38.1
WP_002985266.1\|681028_682156_+	ABC transporter permease	NA	NA	NA	NA
WP_002985264.1\|682152_683271_+	ABC transporter permease	NA	NA	NA	NA
WP_030127452.1\|683842_686575_+	endonuclease/exonuclease/phosphatase family protein	NA	NA	NA	NA
WP_030127453.1\|686852_687353_+	QueT transporter family protein	E7DN70	Pneumococcus_phage	7.1e-05	32.4
WP_030127454.1\|687546_689505_+	NAD-dependent DNA ligase LigA	A0A0K2QQN8	Ralstonia_phage	2.9e-102	34.8
WP_011017609.1\|689518_690541_+	diacylglycerol kinase family lipid kinase	A0A1V0SBJ0	Catovirus	3.6e-19	27.9
WP_002985249.1\|690931_691129_+	F0F1 ATP synthase subunit C	NA	NA	NA	NA
WP_002985244.1\|691163_691880_+	F0F1 ATP synthase subunit A	NA	NA	NA	NA
WP_002990420.1\|691897_692392_+	F0F1 ATP synthase subunit B	NA	NA	NA	NA
WP_002985240.1\|692391_692928_+	F0F1 ATP synthase subunit delta	NA	NA	NA	NA
WP_002985238.1\|692943_694452_+	F0F1 ATP synthase subunit alpha	NA	NA	NA	NA
WP_002985236.1\|694467_695343_+	F0F1 ATP synthase subunit gamma	NA	NA	NA	NA
WP_011017611.1\|695504_696911_+	F0F1 ATP synthase subunit beta	NA	NA	NA	NA
WP_002985233.1\|696923_697340_+	F0F1 ATP synthase subunit epsilon	NA	NA	NA	NA
WP_011889022.1\|697605_697863_+	DUF1146 domain-containing protein	NA	NA	NA	NA
WP_002994428.1\|697927_699199_+	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	NA	NA	NA	NA
WP_011017613.1\|699202_699391_+	DNA-directed RNA polymerase subunit beta	NA	NA	NA	NA
WP_076636779.1\|699426_699966_+	DNA/RNA non-specific endonuclease	NA	NA	NA	NA
WP_030127456.1\|700248_701292_+\|tRNA	phenylalanine--tRNA ligase subunit alpha	A0A2K9L3A8	Tupanvirus	1.0e-29	33.9
WP_111705993.1\|701501_703907_+\|tRNA	phenylalanine--tRNA ligase subunit beta	NA	NA	NA	NA

DBSCAN-SWA_3

739297 : 749900

Streptococcus_phage(57.14%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011054348.1\|739297_741508_-	LTA synthase family protein	W6LM83	Streptococcus_phage	2.9e-268	69.1
WP_030127475.1\|741615_742779_+	class I SAM-dependent rRNA methyltransferase	W6LLI2	Streptococcus_phage	4.5e-143	65.1
WP_002985140.1\|742775_743462_+	type I 3-dehydroquinate dehydratase	W6LP76	Streptococcus_phage	7.0e-88	68.9
WP_002990262.1\|743555_744722_+	chorismate synthase	A0A291AU41	Pandoravirus	4.5e-34	32.8
WP_002985134.1\|744782_745124_+	YlbF/YmcA family competence regulator	A0A1X9I5Y8	Streptococcus_phage	5.9e-19	40.2
WP_030127476.1\|745344_746697_+	glutathione-disulfide reductase	A0A2K5B2C5	Erysipelothrix_phage	9.2e-31	24.2
WP_030127477.1\|746784_748053_-	bifunctional folylpolyglutamate synthase/dihydrofolate synthase	NA	NA	NA	NA
WP_030127478.1\|748082_748523_-	hypothetical protein	NA	NA	NA	NA
WP_011889000.1\|748757_749900_+	cysteine desulfurase	A0A1X6WFP1	Pacmanvirus	6.3e-25	27.5

DBSCAN-SWA_4

846544 : 909974

Streptococcus_phage(67.24%)

terminase,integrase,holin,tail,capsid,tRNA,portal,head

attL 848885:848902|attR 916322:916339

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002990117.1\|846544_847444_+\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_030127486.1\|847516_848755_+	GTPase HflX	NA	NA	NA	NA
WP_002990114.1\|848747_849383_+	cystathionine beta-lyase	NA	NA	NA	NA
848885:848902	attL	NA	NA	NA	NA
WP_002984894.1\|849397_850327_+	ribonuclease Z	NA	NA	NA	NA
WP_002984893.1\|850326_851091_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_023079991.1\|851087_853298_+	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	8.7e-71	29.6
WP_002990109.1\|853447_853966_+	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	3.9e-30	42.4
WP_011184446.1\|854046_854730_+	DnaD domain-containing protein	Q938N2	Temperate_phage	2.2e-09	36.8
WP_076636774.1\|854726_855383_+	endonuclease III	NA	NA	NA	NA
WP_002990104.1\|855454_856141_+\|tRNA	tRNA (adenine-N(1))-methyltransferase	NA	NA	NA	NA
WP_002984887.1\|856130_856919_+	Nif3-like dinuclear metal center hexameric protein	NA	NA	NA	NA
WP_030127488.1\|856958_858065_+	FAD-binding oxidoreductase	NA	NA	NA	NA
WP_002992970.1\|858122_858992_+	glucose-1-phosphate thymidylyltransferase RfbA	K7QKA7	Escherichia_phage	2.4e-101	64.6
WP_002990099.1\|858991_859585_+	dTDP-4-dehydrorhamnose 3,5-epimerase	H9NC63	Sphingomonas_phage	3.7e-08	28.2
WP_002984881.1\|859828_860869_+	dTDP-glucose 4,6-dehydratase	A0A1D7XFE8	Escherichia_phage	1.1e-68	43.9
WP_011528538.1\|860950_862090_-\|integrase	site-specific integrase	A1EAB7	Streptococcus_phage	4.4e-119	55.8
WP_011285632.1\|862217_862484_-	DUF4177 domain-containing protein	NA	NA	NA	NA
WP_011888747.1\|862495_862882_-	hypothetical protein	M1PFJ2	Streptococcus_phage	3.3e-34	55.5
WP_011888951.1\|862884_863235_-	helix-turn-helix transcriptional regulator	M1PKY8	Streptococcus_phage	1.6e-35	62.6
WP_011888950.1\|863530_863701_+	hypothetical protein	X2L066	Streptococcus_phage	5.1e-08	55.8
WP_012560642.1\|863726_864515_-	hypothetical protein	NA	NA	NA	NA
WP_001112862.1\|864565_864757_+	hypothetical protein	A0A141DZR9	Streptococcus_phage	4.7e-18	69.8
WP_023613185.1\|864835_865147_+	hypothetical protein	A1EAC3	Streptococcus_phage	1.4e-48	85.3
WP_011888947.1\|865148_865319_+	hypothetical protein	A7J273	Streptococcus_phage	1.2e-20	89.3
WP_000049475.1\|865311_865515_+	hypothetical protein	NA	NA	NA	NA
WP_002983407.1\|866036_866240_+	hypothetical protein	A7J276	Streptococcus_phage	9.4e-33	100.0
WP_111706000.1\|866327_866627_+	hypothetical protein	A7J277	Streptococcus_phage	8.7e-43	98.0
WP_030127428.1\|866626_867784_+	DUF2800 domain-containing protein	A7J278	Streptococcus_phage	3.0e-216	97.9
WP_086934854.1\|867792_868356_+	DUF2815 family protein	D2J040	Enterococcus_phage	3.3e-51	58.5
WP_111705987.1\|868398_870321_+	DNA polymerase	A7J280	Streptococcus_phage	0.0e+00	98.9
WP_063662381.1\|870325_872710_+	DNA primase	A7J282	Streptococcus_phage	7.4e-286	97.8
WP_023613183.1\|873074_873350_+	VRR-NUC domain-containing protein	A7J283	Streptococcus_phage	1.3e-45	97.8
WP_111706001.1\|873346_874669_+	DEAD/DEAH box helicase family protein	A7J284	Streptococcus_phage	9.6e-251	97.0
WP_023079219.1\|874669_874837_+	hypothetical protein	A7J285	Streptococcus_phage	4.3e-23	92.7
WP_032461948.1\|874833_875100_+	hypothetical protein	A7J287	Streptococcus_phage	2.7e-19	64.0
WP_111681185.1\|875102_875645_+	hypothetical protein	A0MN47	Thermus_phage	2.2e-28	38.9
WP_032461949.1\|875736_875928_+	hypothetical protein	NA	NA	NA	NA
WP_002988747.1\|875924_876341_+	DUF722 domain-containing protein	A7J289	Streptococcus_phage	6.6e-73	100.0
WP_011106637.1\|876430_876883_+\|terminase	terminase small subunit	A7J290	Streptococcus_phage	6.9e-76	100.0
WP_063632647.1\|876872_878150_+\|terminase	PBSX family phage terminase large subunit	A7J291	Streptococcus_phage	6.9e-246	99.5
WP_023611655.1\|878165_879698_+\|portal	phage portal protein	A7J292	Streptococcus_phage	3.3e-287	98.4
WP_032465703.1\|879657_881106_+\|capsid	minor capsid protein	A7J293	Streptococcus_phage	1.2e-278	99.8
WP_011054876.1\|881133_881322_+	hypothetical protein	A7J294	Streptococcus_phage	7.4e-24	100.0
WP_011888934.1\|881326_881593_+	hypothetical protein	Q938K9	Temperate_phage	2.9e-37	96.6
WP_011888933.1\|881754_882324_+	DUF4355 domain-containing protein	A7J296	Streptococcus_phage	1.9e-83	100.0
WP_002983429.1\|882336_883224_+	hypothetical protein	A7J297	Streptococcus_phage	2.1e-161	100.0
WP_011054873.1\|883235_883592_+\|head,tail	phage head-tail connector protein	A7J298	Streptococcus_phage	4.6e-59	100.0
WP_011054872.1\|883602_883881_+	hypothetical protein	A7J299	Streptococcus_phage	1.9e-47	100.0
WP_011106640.1\|883877_884222_+	HK97 gp10 family phage protein	A7J2A0	Streptococcus_phage	5.1e-55	98.2
WP_011054870.1\|884225_884585_+	hypothetical protein	A7J2A1	Streptococcus_phage	1.2e-57	98.3
WP_011054869.1\|884596_885196_+\|tail	phage major tail protein, TP901-1 family	A7J2A2	Streptococcus_phage	1.7e-90	97.1
WP_011888931.1\|885249_885705_+	hypothetical protein	A7J2A3	Streptococcus_phage	5.3e-76	99.3
WP_011054867.1\|885779_886013_+	hypothetical protein	A7J2A4	Streptococcus_phage	6.4e-33	97.4
WP_111706002.1\|886027_890410_+	tape measure protein	A7J2A5	Streptococcus_phage	3.0e-224	74.8
WP_063632651.1\|890421_891264_+\|tail	phage tail protein	A7J2A6	Streptococcus_phage	9.7e-156	97.5
WP_111706003.1\|891273_893256_+\|tail	phage tail protein	A7J2A7	Streptococcus_phage	0.0e+00	93.9
WP_111706004.1\|893252_894476_+	hypothetical protein	A3F657	Streptococcus_phage	8.5e-44	48.9
WP_011284842.1\|894462_894792_+	hypothetical protein	NA	NA	NA	NA
WP_111706005.1\|894802_896689_+	gp58-like family protein	Q938J9	Temperate_phage	1.3e-203	80.3
WP_002987513.1\|896700_897132_+	DUF1617 family protein	Q938J8	Temperate_phage	1.1e-73	100.0
WP_111706006.1\|897134_897740_+	DUF1366 domain-containing protein	Q938J7	Temperate_phage	5.6e-89	99.5
WP_076634525.1\|897757_898033_+	hypothetical protein	A7J2B2	Streptococcus_phage	4.4e-41	98.9
WP_000609113.1\|898029_898257_+\|holin	phage holin	A7J2B3	Streptococcus_phage	5.8e-31	98.7
WP_111706007.1\|898372_899578_+	glucosaminidase domain-containing protein	Q938J4	Temperate_phage	1.8e-211	86.0
WP_011017840.1\|899716_900241_+	DUF4065 domain-containing protein	Q938J3	Temperate_phage	4.0e-99	100.0
WP_011054729.1\|900228_901095_+	DUF334 domain-containing protein	Q938J2	Temperate_phage	3.7e-134	100.0
WP_014635497.1\|901397_902111_+	streptococcal pyrogenic exotoxin SpeM	Q938J1	Temperate_phage	9.0e-78	59.5
WP_020833516.1\|902392_903181_+	streptococcal pyrogenic exotoxin SpeL	Q938J1	Temperate_phage	1.2e-46	41.4
WP_011054546.1\|903291_903480_+	hypothetical protein	A3F673	Streptococcus_phage	1.2e-21	84.7
WP_002989607.1\|904070_904685_+	TVP38/TMEM64 family protein	M1Q152	Streptococcus_phage	6.2e-51	52.3
WP_002984433.1\|904815_905601_-	hypothetical protein	NA	NA	NA	NA
WP_002984437.1\|905610_906309_-	ABC transporter ATP-binding protein	F2Y2R6	Organic_Lake_phycodnavirus	6.6e-09	27.3
WP_002989617.1\|906308_906680_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_030127221.1\|906863_909974_+	DNA polymerase III subunit alpha	A0A2L1IZ23	Streptomyces_phage	5.4e-119	29.8
916322:916339	attR	NA	NA	NA	NA

DBSCAN-SWA_5

1106614 : 1172463

Streptococcus_phage(55.56%)

terminase,integrase,tail,capsid,head,transposase,portal,protease

attL 1131594:1131609|attR 1177817:1177832

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_111706051.1\|1106614_1106794_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_014407532.1\|1107096_1108860_-	dihydrolipoyl dehydrogenase	A0A2K5B2C5	Erysipelothrix_phage	1.5e-33	25.5
WP_030127493.1\|1109190_1110600_-	dihydrolipoamide acetyltransferase	NA	NA	NA	NA
WP_030127492.1\|1110784_1111783_-	alpha-ketoacid dehydrogenase subunit beta	NA	NA	NA	NA
WP_002989983.1\|1111841_1112810_-	thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha	NA	NA	NA	NA
WP_030127491.1\|1113094_1115002_-	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	5.8e-55	30.9
WP_002989987.1\|1115047_1115374_-	hypothetical protein	NA	NA	NA	NA
WP_002984871.1\|1115403_1116189_-	esterase family protein	NA	NA	NA	NA
WP_002984872.1\|1116321_1117983_-	ribonuclease J	NA	NA	NA	NA
WP_011017707.1\|1118186_1118945_-	ABC transporter ATP-binding protein	A0A1V0SE00	Indivirus	5.9e-11	28.3
WP_011017706.1\|1118941_1119811_-	ABC transporter permease	NA	NA	NA	NA
WP_011184452.1\|1120155_1121154_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_030127490.1\|1121507_1123160_+	PavA family fibronectin-binding protein Fbp54	A0A1J0F9J4	Only_Syngen_Nebraska_virus	1.7e-07	41.0
WP_030126713.1\|1123219_1124467_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_030127489.1\|1124456_1125638_-	AI-2E family transporter	NA	NA	NA	NA
WP_002984880.1\|1125695_1126172_-	8-oxo-dGTP diphosphatase	NA	NA	NA	NA
WP_010922229.1\|1126775_1127486_-	streptococcal pyrogenic exotoxin SpeH	NA	NA	NA	NA
WP_047373492.1\|1127511_1128189_-	streptococcal pyrogenic exotoxin SpeI	A0A075M4C7	Staphylococcus_phage	2.4e-27	32.4
WP_011284838.1\|1128462_1129797_-	lysin	Q5MY96	Streptococcus_phage	1.3e-247	93.0
WP_002990010.1\|1129908_1130094_-	hypothetical protein	Q938J5	Temperate_phage	1.9e-24	95.1
WP_002990012.1\|1130090_1130387_-	hypothetical protein	Q938J6	Temperate_phage	3.7e-46	98.0
WP_011054733.1\|1130397_1131009_-	DUF1366 domain-containing protein	Q938J7	Temperate_phage	2.7e-91	100.0
WP_021340778.1\|1131011_1131443_-	DUF1617 family protein	Q938J8	Temperate_phage	5.2e-73	99.3
WP_111706015.1\|1131454_1133470_-	gp58-like family protein	Q938J9	Temperate_phage	1.2e-212	83.9
1131594:1131609	attL	NA	NA	NA	NA
WP_011284842.1\|1133480_1133810_-	hypothetical protein	NA	NA	NA	NA
WP_011284843.1\|1133796_1135011_-	hypothetical protein	A3F657	Streptococcus_phage	5.0e-44	49.5
WP_111706016.1\|1135007_1137155_-\|tail	phage tail protein	Q938K1	Temperate_phage	0.0e+00	94.0
WP_111688276.1\|1137151_1137859_-\|tail	phage tail family protein	Q938K2	Temperate_phage	1.1e-91	69.8
WP_021340814.1\|1137858_1141782_-\|tail	phage tail tape measure protein	J7KDT4	Streptococcus_phage	1.9e-238	48.5
WP_021299462.1\|1141794_1141944_-	hypothetical protein	J7KBS0	Streptococcus_phage	1.7e-15	85.7
WP_011017586.1\|1141991_1142318_-	hypothetical protein	J7KK85	Streptococcus_phage	8.3e-39	75.0
WP_011017585.1\|1142370_1142979_-	hypothetical protein	J7KKC8	Streptococcus_phage	6.7e-74	71.9
WP_011017584.1\|1142994_1143420_-	hypothetical protein	J7KBZ9	Streptococcus_phage	7.2e-67	84.4
WP_003055321.1\|1143416_1143794_-	HK97 gp10 family phage protein	J7KDM3	Streptococcus_phage	1.5e-47	76.0
WP_003055344.1\|1143790_1144138_-\|head	phage head closure protein	J7KJ42	Streptococcus_phage	2.6e-46	80.9
WP_021340811.1\|1144134_1144437_-\|head,tail	phage head-tail connector protein	J7KC36	Streptococcus_phage	3.0e-43	88.8
WP_021340812.1\|1144581_1145766_-\|capsid	phage major capsid protein	J7KJ82	Streptococcus_phage	1.5e-162	76.6
WP_032465106.1\|1145790_1146456_-\|protease	Clp protease ClpP	M1Q115	Streptococcus_phage	1.9e-90	77.7
WP_111688275.1\|1146433_1147654_-\|portal	phage portal protein	J7KDU3	Streptococcus_phage	5.8e-186	81.9
WP_002985363.1\|1147687_1147912_-	hypothetical protein	Q938K9	Temperate_phage	3.6e-17	61.4
WP_002985365.1\|1147904_1148075_-	hypothetical protein	J7KK43	Streptococcus_phage	2.3e-08	62.5
WP_021340859.1\|1148071_1149826_-\|terminase	terminase large subunit	J7KKD1	Streptococcus_phage	0.0e+00	96.1
WP_002985371.1\|1149840_1150308_-\|terminase	phage terminase small subunit P27 family	J7KC46	Streptococcus_phage	3.9e-82	98.7
WP_029714359.1\|1150476_1150818_-	HNH endonuclease	J7KH36	Streptococcus_phage	9.6e-54	89.8
WP_001132273.1\|1151053_1151239_+	type II toxin-antitoxin system HicA family toxin	D6PSW1	Lactobacillus_phage	1.7e-09	54.0
WP_002987543.1\|1151290_1151668_+	type II toxin-antitoxin system HicB family antitoxin	I3NLB2	Bifidobacterium_phage	3.3e-15	44.0
WP_002990048.1\|1151983_1152196_+	hypothetical protein	NA	NA	NA	NA
WP_011284864.1\|1152285_1153200_-	hypothetical protein	NA	NA	NA	NA
WP_011017866.1\|1153971_1154412_-	ArpU family transcriptional regulator	Q938L8	Temperate_phage	5.0e-79	100.0
WP_021340848.1\|1154684_1155320_-	SAM-dependent DNA methyltransferase	L0P368	Streptococcus_phage	2.5e-87	68.4
WP_002987468.1\|1155319_1155721_-	hypothetical protein	NA	NA	NA	NA
WP_021340166.1\|1155818_1156046_-	hypothetical protein	A3F630	Streptococcus_phage	1.9e-26	76.0
WP_021340844.1\|1156049_1156535_-	class I SAM-dependent methyltransferase	A0A097PAU8	Streptococcus_pyogenes_phage	4.6e-94	98.8
WP_032459898.1\|1156538_1156823_-	hypothetical protein	A3F628	Streptococcus_phage	8.6e-40	91.5
WP_021340843.1\|1156819_1157233_-	hypothetical protein	Q938M1	Temperate_phage	2.4e-35	63.8
WP_011018137.1\|1157229_1157514_-	DUF3310 domain-containing protein	A0A1P8VVP5	Streptococcus_phage	2.7e-49	97.9
WP_032459900.1\|1157755_1158112_-	hypothetical protein	A0A097PAU4	Streptococcus_pyogenes_phage	4.6e-59	96.6
WP_032459901.1\|1158095_1158416_-	VRR-NUC domain-containing protein	A0A1P8VVL5	Streptococcus_phage	5.5e-51	94.3
WP_014411877.1\|1160539_1161352_-	bifunctional DNA primase/polymerase	A0A1P8VVM6	Streptococcus_phage	1.3e-152	97.4
WP_002995969.1\|1161354_1161813_-	DUF669 domain-containing protein	A0A1P8VVN0	Streptococcus_phage	3.8e-82	100.0
WP_021340851.1\|1161828_1163058_-	DEAD/DEAH box helicase	A0A1P8VVM2	Streptococcus_phage	1.3e-236	99.8
WP_002995975.1\|1163159_1163840_-	AAA family ATPase	A0A1P8VVS4	Streptococcus_phage	1.6e-129	100.0
WP_021340846.1\|1163840_1164323_-	siphovirus Gp157 family protein	A0A1P8VVS5	Streptococcus_phage	7.9e-78	98.8
WP_021340847.1\|1164551_1164866_-	helix-turn-helix transcriptional regulator	A0A1P8VVN6	Streptococcus_phage	1.2e-50	95.2
WP_165357622.1\|1164881_1165019_-	hypothetical protein	A0A1P8VVR9	Streptococcus_phage	5.4e-16	91.1
WP_011054584.1\|1165015_1165312_-	hypothetical protein	A0A097PAT8	Streptococcus_pyogenes_phage	2.1e-49	100.0
WP_029714276.1\|1165348_1165612_-	hypothetical protein	A0A097PAP6	Streptococcus_pyogenes_phage	3.6e-40	98.9
WP_021340169.1\|1165623_1165863_-	helix-turn-helix transcriptional regulator	A0A097PBE6	Streptococcus_pyogenes_phage	3.1e-35	97.5
WP_111688274.1\|1165912_1166419_+	hypothetical protein	NA	NA	NA	NA
WP_021340823.1\|1166415_1166562_-	hypothetical protein	NA	NA	NA	NA
WP_021340822.1\|1166736_1167525_+	peptidase S24	A0A1S5SD15	Streptococcus_phage	2.9e-85	62.6
WP_011106738.1\|1167534_1167840_+	membrane protein	NA	NA	NA	NA
WP_011054595.1\|1167959_1169048_+\|integrase	site-specific integrase	A0A097PAS9	Streptococcus_pyogenes_phage	4.7e-203	99.2
WP_030127220.1\|1169321_1169942_+	DUF3862 domain-containing protein	NA	NA	NA	NA
WP_030127219.1\|1170198_1172463_-	glycogen/starch/alpha-glucan family phosphorylase	Q8B3H5	Iris_mild_mosaic_virus	1.2e-11	43.7
1177817:1177832	attR	NA	NA	NA	NA

DBSCAN-SWA_6

1219277 : 1237418

Streptococcus_phage(94.74%)

integrase

attL 1218585:1218601|attR 1249784:1249800

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1218585:1218601	attL	NA	NA	NA	NA
WP_078136843.1\|1219277_1219733_-	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	4.0e-23	40.0
WP_001291561.1\|1219892_1221110_-\|integrase	tyrosine-type recombinase/integrase	A0A1S5SEW7	Streptococcus_phage	3.7e-233	100.0
WP_000814511.1\|1221191_1221395_-	excisionase	A0A1S5SF07	Streptococcus_phage	4.0e-31	100.0
WP_000857133.1\|1221855_1222086_-	helix-turn-helix domain-containing protein	A0A1S5SEX1	Streptococcus_phage	2.7e-36	100.0
WP_000804885.1\|1222082_1222505_-	sigma-70 family RNA polymerase sigma factor	A0A1S5SEW0	Streptococcus_phage	2.5e-72	100.0
WP_001227347.1\|1223009_1223363_+	helix-turn-helix domain-containing protein	A0A1S5SFA6	Streptococcus_phage	1.3e-58	100.0
WP_000336323.1\|1223422_1223590_-	cysteine-rich KTR domain-containing protein	D0R0F6	Streptococcus_phage	1.6e-14	68.0
WP_030127075.1\|1223708_1225628_-	tetracycline resistance ribosomal protection protein Tet(M)	A0A1S5SF82	Streptococcus_phage	0.0e+00	98.3
WP_001791010.1\|1225643_1225760_-	tetracycline resistance determinant leader peptide	NA	NA	NA	NA
WP_001224320.1\|1226004_1226940_-	conjugal transfer protein	A0A1S5SF22	Streptococcus_phage	7.7e-170	99.0
WP_000769868.1\|1226936_1227938_-	lysozyme family protein	A0A1S5SEZ8	Streptococcus_phage	5.0e-191	100.0
WP_000804748.1\|1227934_1230112_-	membrane protein	A0A1S5SF30	Streptococcus_phage	0.0e+00	100.0
WP_000331160.1\|1230114_1232562_-	ATP-binding protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	100.0
WP_000506270.1\|1232545_1233052_-	conjugal transfer protein	A0A1S5SEX7	Streptococcus_phage	8.6e-91	100.0
WP_000342539.1\|1233026_1233524_-	antirestriction protein ArdA	A0A1S5SF25	Streptococcus_phage	1.7e-91	100.0
WP_001009056.1\|1233640_1233862_-	hypothetical protein	A0A1S5SEY0	Streptococcus_phage	4.3e-31	100.0
WP_000398284.1\|1233904_1235110_-	replication initiation factor domain-containing protein	A0A1S5SEX3	Streptococcus_phage	2.8e-233	100.0
WP_000879507.1\|1235132_1235285_-	hypothetical protein	NA	NA	NA	NA
WP_000813488.1\|1235287_1236673_-	DNA translocase FtsK	A0A1S5SFB5	Streptococcus_phage	1.1e-265	100.0
WP_000985015.1\|1236701_1237088_-	YdcP family protein	A0A1S5SF96	Streptococcus_phage	3.0e-64	100.0
WP_000420682.1\|1237103_1237418_-	YdcP family protein	A0A1S5SF38	Streptococcus_phage	5.2e-54	100.0
1249784:1249800	attR	NA	NA	NA	NA

DBSCAN-SWA_7

1294672 : 1380528

Temperate_phage(38.98%)

terminase,holin,integrase,tail,capsid,tRNA,portal,protease

attL 1336160:1336176|attR 1387845:1387861

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002995750.1\|1294672_1295368_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_011184659.1\|1295386_1296148_-	DUF3169 family protein	NA	NA	NA	NA
WP_030127117.1\|1296144_1296360_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_030127118.1\|1296698_1299317_-\|tRNA	alanine--tRNA ligase	A0A1V0SK38	Klosneuvirus	1.9e-61	33.9
WP_002984003.1\|1299703_1300759_-	peptidylprolyl isomerase PrsA	NA	NA	NA	NA
WP_002989211.1\|1300821_1301529_-	O-methyltransferase	A0A2P1JQT7	Mycobacterium_phage	2.6e-08	27.2
WP_002995765.1\|1301594_1302791_-	OFA family MFS transporter	NA	NA	NA	NA
WP_030127119.1\|1303165_1304971_-	oligoendopeptidase F	NA	NA	NA	NA
WP_002983995.1\|1304983_1305946_-	competence protein CoiA	NA	NA	NA	NA
WP_030127120.1\|1306240_1306957_-	rRNA pseudouridine synthase	NA	NA	NA	NA
WP_021340997.1\|1307075_1307780_-	glucosamine-6-phosphate deaminase	NA	NA	NA	NA
WP_030127121.1\|1307981_1309010_+\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_030127122.1\|1309016_1310237_+	DUF3114 domain-containing protein	NA	NA	NA	NA
WP_030127123.1\|1310350_1310941_-	serine hydrolase	NA	NA	NA	NA
WP_030127124.1\|1310937_1311186_-	hypothetical protein	NA	NA	NA	NA
WP_011017948.1\|1311554_1312160_-	superoxide dismutase	Q56AR7	Bacillus_thuringiensis_phage	1.8e-58	53.2
WP_030127125.1\|1312256_1313297_-	DNA polymerase III subunit delta	NA	NA	NA	NA
WP_030127126.1\|1313367_1315611_-	DNA internalization-related competence protein ComEC/Rec2	M1PSD2	Streptococcus_phage	1.8e-55	59.2
WP_002983967.1\|1315591_1316254_-	ComEA family DNA-binding protein	NA	NA	NA	NA
WP_030127127.1\|1316452_1317193_-	1-acyl-sn-glycerol-3-phosphate acyltransferase	NA	NA	NA	NA
WP_030127128.1\|1317232_1318087_+\|tRNA	tRNA1(Val) (adenine(37)-N6)-methyltransferase	NA	NA	NA	NA
WP_002989164.1\|1318076_1318355_+	GIY-YIG nuclease family protein	W8W2G4	Invertebrate_iridovirus	1.8e-05	36.0
WP_030127129.1\|1318378_1320379_-	potassium transporter Kup	M1IBC2	Acanthocystis_turfacea_Chlorella_virus	5.8e-66	34.0
WP_002989158.1\|1320506_1322126_-	DEAD/DEAH box helicase	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	1.9e-59	36.5
WP_030127130.1\|1322432_1323977_-	peptide chain release factor 3	A0A1B0RXH7	Streptococcus_phage	2.4e-35	29.1
WP_011017956.1\|1324224_1324920_-	TIGR02206 family membrane protein	NA	NA	NA	NA
WP_011017957.1\|1324999_1326391_-	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	NA	NA	NA	NA
WP_002994369.1\|1326589_1327636_-	D-alanine--D-alanine ligase	NA	NA	NA	NA
WP_002983939.1\|1327736_1328333_-	recombination protein RecR	NA	NA	NA	NA
WP_014407680.1\|1329122_1329902_-	formate/nitrite transporter family protein	NA	NA	NA	NA
WP_002989140.1\|1330025_1330568_-	hypothetical protein	NA	NA	NA	NA
WP_002983930.1\|1330728_1331250_-	transcription repressor NadR	NA	NA	NA	NA
WP_002983928.1\|1331356_1332052_-	phosphoglycerate mutase	NA	NA	NA	NA
WP_021299339.1\|1332290_1333226_+	dihydroorotate oxidase	A0A1V0SH91	Hokovirus	4.6e-66	45.1
WP_011284945.1\|1333525_1335388_-	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	5.4e-90	33.8
WP_011017964.1\|1335917_1336100_-	hypothetical protein	A3F673	Streptococcus_phage	1.4e-19	76.7
1336160:1336176	attL	NA	NA	NA	NA
WP_002988472.1\|1336212_1336995_-	exotoxin	A0A097PAT7	Streptococcus_pyogenes_phage	4.3e-49	45.8
WP_111706019.1\|1337242_1338367_-	Fic family protein	D7RWK9	Brochothrix_phage	3.1e-93	49.1
WP_032460576.1\|1338502_1339720_-	glucosaminidase domain-containing protein	A0A1P8VVM5	Streptococcus_phage	9.1e-163	59.3
WP_003058873.1\|1339838_1340066_-\|holin	phage holin	A7J2B3	Streptococcus_phage	2.0e-31	100.0
WP_002987582.1\|1340062_1340338_-	hypothetical protein	A7J2B2	Streptococcus_phage	2.6e-41	100.0
WP_030127708.1\|1340347_1340965_-	hypothetical protein	A3F662	Streptococcus_phage	8.3e-88	94.6
WP_002988795.1\|1340967_1341129_-	hypothetical protein	NA	NA	NA	NA
WP_111706020.1\|1341142_1343038_-	gp58-like family protein	Q938J9	Temperate_phage	5.9e-76	52.8
WP_011284842.1\|1343048_1343378_-	hypothetical protein	NA	NA	NA	NA
WP_011284843.1\|1343364_1344579_-	hypothetical protein	A3F657	Streptococcus_phage	5.0e-44	49.5
WP_111706021.1\|1344575_1346723_-\|tail	phage tail protein	Q938K1	Temperate_phage	0.0e+00	95.4
WP_011054737.1\|1346719_1347436_-\|tail	phage tail family protein	Q938K2	Temperate_phage	2.9e-137	100.0
WP_023612368.1\|1347432_1350693_-	tape measure protein	Q938K3	Temperate_phage	0.0e+00	99.5
WP_011284973.1\|1350682_1351264_-	hypothetical protein	Q938K4	Temperate_phage	4.9e-106	99.5
WP_011054740.1\|1351267_1351702_-	hypothetical protein	Q938K5	Temperate_phage	2.6e-72	100.0
WP_011054741.1\|1351740_1352226_-	hypothetical protein	Q938K6	Temperate_phage	1.6e-86	100.0
WP_010922084.1\|1352225_1352624_-\|capsid	phage capsid protein	Q79S87	Temperate_phage	3.5e-71	100.0
WP_010922083.1\|1352620_1352977_-	hypothetical protein	Q79S88	Temperate_phage	4.5e-62	100.0
WP_010922082.1\|1352976_1353309_-	hypothetical protein	Q79S86	Temperate_phage	9.6e-59	100.0
WP_111706022.1\|1353298_1353715_-	hypothetical protein	Q938K7	Temperate_phage	3.3e-56	99.1
WP_010922080.1\|1353768_1354587_-\|capsid	N4-gp56 family major capsid protein	Q79S85	Temperate_phage	4.0e-146	100.0
WP_011106689.1\|1354590_1355205_-	hypothetical protein	Q938K8	Temperate_phage	1.3e-96	100.0
WP_002986829.1\|1355659_1355899_-	hypothetical protein	Q938L0	Temperate_phage	2.8e-36	100.0
WP_111706023.1\|1355870_1357349_-\|capsid	phage minor capsid protein	Q938L1	Temperate_phage	5.3e-274	99.8
WP_002986832.1\|1357353_1358856_-\|portal	phage portal protein	Q938L2	Temperate_phage	5.4e-282	100.0
WP_010922074.1\|1358869_1360081_-\|terminase	PBSX family phage terminase large subunit	Q938L3	Temperate_phage	3.7e-225	99.7
WP_023612332.1\|1360163_1360637_-	hypothetical protein	Q938L4	Temperate_phage	7.3e-76	98.7
WP_002986841.1\|1360687_1361065_-	ASCH domain-containing protein	Q938L5	Temperate_phage	1.7e-67	100.0
WP_076639321.1\|1361125_1361509_-	GNAT family N-acetyltransferase	B5SP24	Lactococcus_phage	3.9e-35	58.5
WP_002986850.1\|1361517_1362195_-	hypothetical protein	Q938L6	Temperate_phage	8.7e-131	100.0
WP_002986854.1\|1362173_1362692_-	ParB N-terminal domain-containing protein	Q938L7	Temperate_phage	1.5e-90	100.0
WP_011054748.1\|1362772_1363030_+	hypothetical protein	NA	NA	NA	NA
WP_032460571.1\|1363604_1364042_-	DUF1492 domain-containing protein	A0A097PBF1	Streptococcus_pyogenes_phage	6.7e-76	98.6
WP_010922070.1\|1364308_1364944_-	SAM-dependent DNA methyltransferase	L0P368	Streptococcus_phage	2.0e-89	69.4
WP_032460570.1\|1364945_1365230_-	hypothetical protein	A0A097PAV1	Streptococcus_pyogenes_phage	2.8e-38	88.3
WP_032460569.1\|1365226_1365640_-	hypothetical protein	Q938M1	Temperate_phage	6.4e-36	65.2
WP_002987593.1\|1365649_1365919_-	hypothetical protein	A0A1P8VVR6	Streptococcus_phage	3.1e-47	100.0
WP_011017568.1\|1365915_1366200_-	DUF3310 domain-containing protein	A0A1P8VVP5	Streptococcus_phage	7.0e-50	100.0
WP_030127675.1\|1366193_1366382_-	hypothetical protein	A3F626	Streptococcus_phage	6.7e-09	82.9
WP_023612320.1\|1366605_1367001_-	RusA family crossover junction endodeoxyribonuclease	Q5YA86	Bacillus_phage	1.8e-40	58.8
WP_003059078.1\|1366993_1367176_-	hypothetical protein	NA	NA	NA	NA
WP_023612365.1\|1367416_1369660_-	AAA family ATPase	Q5YA88	Bacillus_phage	4.7e-282	63.7
WP_023612331.1\|1369682_1369877_-	hypothetical protein	NA	NA	NA	NA
WP_080262841.1\|1369889_1371473_-	DEAD/DEAH box helicase	A0A097BY72	Enterococcus_phage	2.0e-234	77.8
WP_003056185.1\|1371472_1372066_-	hypothetical protein	A0A097BY29	Enterococcus_phage	1.7e-29	43.5
WP_003056188.1\|1372260_1373343_-	AAA family ATPase	A0A0K2CZH1	Paenibacillus_phage	2.5e-103	53.3
WP_023612340.1\|1373357_1374674_-	AAA family ATPase	A0A097BY67	Enterococcus_phage	7.8e-152	63.8
WP_003056170.1\|1374660_1374903_-	hypothetical protein	NA	NA	NA	NA
WP_023612348.1\|1374904_1375123_-	hypothetical protein	NA	NA	NA	NA
WP_164492191.1\|1375132_1375276_-	hypothetical protein	A0A1P8VVR9	Streptococcus_phage	3.4e-13	83.7
WP_023612302.1\|1375259_1375490_-	hypothetical protein	NA	NA	NA	NA
WP_023611288.1\|1375993_1376353_+	helix-turn-helix transcriptional regulator	A0A1P8VVN3	Streptococcus_phage	1.7e-56	95.0
WP_030126053.1\|1376336_1376714_+	ImmA/IrrE family metallo-endopeptidase	A0A1P8VVK5	Streptococcus_phage	1.6e-54	77.6
WP_023612337.1\|1376724_1377246_+	hypothetical protein	Q938N8	Temperate_phage	7.5e-66	97.7
WP_023612372.1\|1377364_1378441_+\|integrase	site-specific integrase	Q0R5B4	Streptococcus_phage	7.5e-68	41.2
WP_002985298.1\|1378803_1379151_-	50S ribosomal protein L19	NA	NA	NA	NA
WP_030127672.1\|1379265_1380528_-	voltage-gated chloride channel family protein	A0A1X9I5Z9	Streptococcus_phage	6.4e-95	51.3
1387845:1387861	attR	NA	NA	NA	NA

DBSCAN-SWA_8

1467275 : 1473925

Streptococcus_phage(66.67%)

portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_010922009.1\|1467275_1468100_-	asparagine ligase A	M1PB22	Moumouvirus	6.2e-22	33.1
WP_030127194.1\|1468123_1468462_-	Fic family protein	NA	NA	NA	NA
WP_011285436.1\|1468878_1469193_-	hypothetical protein	Q6DMT0	Streptococcus_phage	4.9e-20	64.5
WP_010922006.1\|1469258_1469711_-\|portal	phage portal protein	E4ZFM3	Streptococcus_phage	4.4e-62	84.9
WP_010922005.1\|1469815_1470088_-	hypothetical protein	E4ZFM1	Streptococcus_phage	1.2e-06	48.1
WP_011285435.1\|1470106_1470412_-	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_002991611.1\|1470411_1470714_-	type II toxin-antitoxin system RelB/DinJ family antitoxin	NA	NA	NA	NA
WP_015055928.1\|1470768_1470945_-	prophage LambdaSa04	M1PSF2	Streptococcus_phage	3.2e-21	86.2
WP_136040166.1\|1470960_1471854_+	hypothetical protein	NA	NA	NA	NA
WP_010922001.1\|1471853_1472078_+	hypothetical protein	NA	NA	NA	NA
WP_030127191.1\|1473715_1473925_+	helix-turn-helix transcriptional regulator	A0A2K5B263	Erysipelothrix_phage	9.8e-17	61.5

DBSCAN-SWA_9

1579600 : 1585634

Streptococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_030127153.1\|1579600_1580428_+	exodeoxyribonuclease III	M1PSC0	Streptococcus_phage	1.7e-128	79.9
WP_002995120.1\|1580501_1580858_-	arsenate reductase family protein	M1PLC0	Streptococcus_phage	2.8e-40	66.7
WP_011017427.1\|1581156_1581786_+	CutC family protein	NA	NA	NA	NA
WP_002985833.1\|1581832_1582225_-	hypothetical protein	NA	NA	NA	NA
WP_030127152.1\|1582251_1583115_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	1.2e-116	75.7
WP_002985838.1\|1583119_1583443_-	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	1.3e-28	59.4
WP_011017422.1\|1583847_1584087_-	hypothetical protein	NA	NA	NA	NA
WP_030127151.1\|1584105_1584981_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	2.0e-55	41.4
WP_002990917.1\|1584998_1585634_-	dTMP kinase	M1PSC7	Streptococcus_phage	2.7e-65	63.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_LS483414

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection