CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_LS483441	Aeromonas caviae strain NCTC12244 chromosome 1	11 crisprs	DinG,WYL,DEDDh,cas3,csa3	0	4	3	0

1. NZ_LS483441

CRISPR-Cas detection and classification

Crispr_ID: NZ_LS483441_1

• CRISPR_ID: NZ_LS483441_1
• CRISPR_location: 21147-21293
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_LS483441_1

Consensus_repeat	Method
CAGCTTCAACCCCGCTTATCGCATGGTCACAAACTCTTCCGCGCTGGT	CRISPRCasFinder

spacers of NZ_LS483441_1

>1.1|21195|51|NZ_LS483441|CRISPRCasFinder
CGGATGGTGAGTGGAAACACAGTTGTAGAAGCTGGTCTGATAATGACAGGC

CRISPR arrays and Neighbor proteins around NZ_LS483441_1

CRISPR arrays

The CRISPR arrays of NZ_LS483441_1

>merge|NZ_LS483441|1|21147-21293|CRISPRCasFinder
CAGCTTCAACCCCGCTTATCGCATGGTCACAAACTCTTCCGCGCTGGTCGGATGGTGAGTGGAAACACAGTTGTAGAAGCTGGTCTGATAATGACAGGCCAGCTTCAACCCCGCTTATCGCATGGTCACAAACTCTTCCGCACTGGT

>NZ_LS483441|1|1|21147-21293|CRISPRCasFinder
CAGCTTCAACCCCGCTTATCGCATGGTCACAAACTCTTCCGCGCTGGT	CGGATGGTGAGTGGAAACACAGTTGTAGAAGCTGGTCTGATAATGACAGGC
CAGCTTCAACCCCGCTTATCGCATGGTCACAAACTCTTCCGCACTGGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LS483441.1|WP_042016162.1|28964_29555_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NZ_LS483441.1|WP_042016147.1|13015_13699_-|response-regulator	unknown	unknown	gnl|CDD|182522
NZ_LS483441.1|WP_042016144.1|10966_11791_-|AraC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|380379
NZ_LS483441.1|WP_041214197.1|30434_30953_+|ricin-type-beta-trefoil-lectin-domain-protein	unknown	unknown	gnl|CDD|214672
NZ_LS483441.1|WP_041214189.1|10803_11037_+|hypothetical-protein	unknown	unknown	unknown
NZ_LS483441.1|WP_042016168.1|33632_34361_-|tRNA-(guanosine(18)-2'-O)-methyltransferase-TrmH	unknown	unknown	gnl|CDD|236837
NZ_LS483441.1|WP_042016165.1|32967_33630_-|CatB-related-O-acetyltransferase	unknown	unknown	gnl|CDD|100040
NZ_LS483441.1|WP_042016145.1|11883_13011_+|multidrug-effflux-MFS-transporter	unknown	unknown	gnl|CDD|340878
NZ_LS483441.1|WP_042016150.1|13737_16326_-|sensor-histidine-kinase-KdpD	unknown	unknown	gnl|CDD|225115
NZ_LS483441.1|WP_042016152.1|17016_19074_-|potassium-transporting-ATPase-subunit-KdpB	unknown	unknown	gnl|CDD|234905
NZ_LS483441.1|WP_042016141.1|8755_9196_+|Hsp20-family-protein	unknown	unknown	gnl|CDD|182691
NZ_LS483441.1|WP_039040661.1|27861_28968_-|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl|CDD|273776
NZ_LS483441.1|WP_042016154.1|19129_20812_-|potassium-transporting-ATPase-subunit-KdpA	unknown	unknown	gnl|CDD|235494
NZ_LS483441.1|WP_042016142.1|9269_10520_-|valine--pyruvate-transaminase	unknown	unknown	gnl|CDD|236517
NZ_LS483441.1|WP_041212076.1|16428_16956_-|potassium-transporting-ATPase-subunit-C	unknown	unknown	gnl|CDD|376890
NZ_LS483441.1|WP_039040660.1|24765_27846_-|multidrug-efflux-RND-transporter-permease-subunit	unknown	unknown	gnl|CDD|169983
NZ_LS483441.1|WP_042016163.1|31930_32971_-|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|182697
NZ_LS483441.1|WP_042016159.1|22686_24645_-|PAS-domain-S-box-protein	unknown	unknown	gnl|CDD|226654
NZ_LS483441.1|WP_039040667.1|34468_36586_-|bifunctional-GTP-diphosphokinase/guanosine-3',5'-bis-pyrophosphate-3'-pyrophosphohydrolase	unknown	unknown	gnl|CDD|236843
NZ_LS483441.1|WP_042016195.1|31023_31827_-|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl|CDD|182878

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_LS483441.1|WP_042016162.1|28964_29555_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.27518e-15
NZ_LS483441.1|WP_042016147.1|13015_13699_-|response-regulator	gnl|CDD|182522	PRK10529, PRK10529, DNA-binding transcriptional activator KdpE; Provisional.	1.20238e-72
NZ_LS483441.1|WP_042016144.1|10966_11791_-|AraC-family-transcriptional-regulator	gnl|CDD|380379	cd06124, cupin_NimR-like_N, AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain. This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	7.98738e-32
NZ_LS483441.1|WP_041214197.1|30434_30953_+|ricin-type-beta-trefoil-lectin-domain-protein	gnl|CDD|214672	smart00458, RICIN, Ricin-type beta-trefoil. Carbohydrate-binding domain formed from presumed gene triplication.	2.1827e-07
NZ_LS483441.1|WP_042016168.1|33632_34361_-|tRNA-(guanosine(18)-2'-O)-methyltransferase-TrmH	gnl|CDD|236837	PRK11081, PRK11081, tRNA guanosine-2'-O-methyltransferase; Provisional.	5.24996e-154
NZ_LS483441.1|WP_042016165.1|32967_33630_-|CatB-related-O-acetyltransferase	gnl|CDD|100040	cd03349, LbH_XAT, Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. Members of this class of enzymes include Enterococcus faecium streptogramin A acetyltransferase and Pseudomonas aeruginosa chloramphenicol acetyltransferase. They contain repeated copies of a six-residue hexapeptide repeat sequence motif (X-[STAV]-X-[LIV]-[GAED]-X) and adopt a left-handed parallel beta helix (LbH) structure. The active enzyme is a trimer with CoA and substrate binding sites at the interface of two separate LbH subunits. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients.	3.46383e-69
NZ_LS483441.1|WP_042016145.1|11883_13011_+|multidrug-effflux-MFS-transporter	gnl|CDD|340878	cd17320, MFS_MdfA_MDR_like, Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.69236e-73
NZ_LS483441.1|WP_042016150.1|13737_16326_-|sensor-histidine-kinase-KdpD	gnl|CDD|225115	COG2205, KdpD, Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms].	0
NZ_LS483441.1|WP_042016152.1|17016_19074_-|potassium-transporting-ATPase-subunit-KdpB	gnl|CDD|234905	PRK01122, PRK01122, potassium-transporting ATPase subunit KdpB.	0
NZ_LS483441.1|WP_042016141.1|8755_9196_+|Hsp20-family-protein	gnl|CDD|182691	PRK10743, PRK10743, heat shock chaperone IbpA.	2.89829e-46
NZ_LS483441.1|WP_039040661.1|27861_28968_-|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl|CDD|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	3.06044e-75
NZ_LS483441.1|WP_042016154.1|19129_20812_-|potassium-transporting-ATPase-subunit-KdpA	gnl|CDD|235494	PRK05482, PRK05482, potassium-transporting ATPase subunit A; Provisional.	0
NZ_LS483441.1|WP_042016142.1|9269_10520_-|valine--pyruvate-transaminase	gnl|CDD|236517	PRK09440, avtA, valine--pyruvate transaminase; Provisional.	0
NZ_LS483441.1|WP_041212076.1|16428_16956_-|potassium-transporting-ATPase-subunit-C	gnl|CDD|376890	pfam02669, KdpC, K+-transporting ATPase, c chain. This family consists of K+-transporting ATPase, c chain, KdpC. KdpC forms strong interactions with the KdpA subunit, serving to assemble and stabilize the Kdp complex. It has been suggested that KdpC could be one of the connecting links between the energy providing subunit KdpB and the K+-transporting subunit KdpA. The K+ transport system actively transports K+ ions via ATP hydrolysis.	1.42839e-62
NZ_LS483441.1|WP_039040660.1|24765_27846_-|multidrug-efflux-RND-transporter-permease-subunit	gnl|CDD|169983	PRK09579, PRK09579, multidrug efflux RND transporter permease subunit.	0
NZ_LS483441.1|WP_042016163.1|31930_32971_-|alpha/beta-fold-hydrolase	gnl|CDD|182697	PRK10749, PRK10749, lysophospholipase L2; Provisional.	2.70502e-109
NZ_LS483441.1|WP_042016159.1|22686_24645_-|PAS-domain-S-box-protein	gnl|CDD|226654	COG4191, COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms].	3.15332e-33
NZ_LS483441.1|WP_039040667.1|34468_36586_-|bifunctional-GTP-diphosphokinase/guanosine-3',5'-bis-pyrophosphate-3'-pyrophosphohydrolase	gnl|CDD|236843	PRK11092, PRK11092, bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase.	0
NZ_LS483441.1|WP_042016195.1|31023_31827_-|Cof-type-HAD-IIB-family-hydrolase	gnl|CDD|182878	PRK10976, PRK10976, putative hydrolase; Provisional.	6.00719e-98

Protein sequences

>NZ_LS483441.1|WP_042016154.1|19129_20812_-|potassium-transporting-ATPase-subunit-KdpA
MWQEIIYPVAFVLLVLLPAPLLGNYLYRVFEGKSRWLAPLERATLACCGTDGREQDWKSYALSLLAFNGAGFGLLFLILMAQGLLPLNPQQLPGLNWQLAFNTAVSFMTNTNWQAYSGEASLSYFSQMVGLTTQNFVSAATGAAVAIALFRGIARQQTTHLGNFWQDLVRFCLYVLLPMALILALLLVWQGVPQSLSAYLPFHALEGQEQLLPIGPAASQIAIKQLGSNGGGFFGINSAHPFENPTALSNWLEMVALLTLAAAMVCTLGRYVKDLAHSRAILIAMTIMLVLGLCLAIGQELKPDPALAHLTSEAGNWEGKESRFGPVLSSIWEVATTAASNGSVNAMHDSFTPLGGMVGMINMLLGEVVFGGVGAGIYGMMLFVLLTVFLCGLMVGRTPTYLGKRLGITEMKWVVASMLVMPVGVLVIGGITLLMPNSATVIGHDGPHGLSRLIYAYASAAGNNGSAFAGFAAADSWQCIAIGLAMLLGRFGYIIPVLAIAGQLARAPRQETSEGDFPISGPLFITLLIVTVLLMGGLSFLPVLALGPVAEHLSLLGGAF
>NZ_LS483441.1|WP_042016152.1|17016_19074_-|potassium-transporting-ATPase-subunit-KdpB
MSKSASMSTDTIQVKGKKQKSQILQAMVEALYRFNPRALFGSPILFTLWLAAVMATLESLLGQPLSGVAPSLAWQLTAWLWLTLWFANFAETLAEGRGKARADSLKAGMSQLKARRVTSPQDDKGEWVPATSLLKGDLVLVRSGEMIPADGEVVAGIASVNEAAITGESAPVIRESGTDRSGVTGNTTVVSDEIWVRITNNPGESTLDRMIALVEGAKRQKTPNEMALDALLVGLTLIFLLVVATLPWFLDYNGTQVPRLYLLALFITLIPTTIGGLLSAIGIAGMDRLVKLNVIAKSGRAVEAAGDVRTLLLDKTGTITFGNRMADELIPAPGVDPSLLAQAAMLASLGDNTPEGKSILTLAGKSHTRPSQLESDILIPFSAETRLSGLDRNGHHYRKGAVDAVLRYLSLDRKAVPELILKSVDNIARQGGTPLLVCTHEKLLGVVYLKDIIKPGIKARFQTLRHMGIRTVMITGDNPLTAAAIAAEAGVDDFIAEATPEKKLAYIRQEQADGRLVAMCGDGANDAPALAQADVGLAMNEGTQAAKEAGNLVDLDSNPTKLLDVVLVGKQLLVTRGALTTFSIANDVAKYFAILPALFIAAYPQLGALNLMQLGSPESAILSAIIFNALIIVALVPLALRGVSLKGTAASLLRRNLLIYGVGGLIVPFIGIKLIDLVITGLGLV
>NZ_LS483441.1|WP_041212076.1|16428_16956_-|potassium-transporting-ATPase-subunit-C
MIAIRTLLTLTLLLGVAYPLAVTGLAQLLFPWQANGSLLTNAKQQVVGSALLAQKFERADYFHSRPSASDFATIGGGGSNLGMSSPLRAEFAAAAARAQPEARVPALLTRSASGLDPHLPLDAALAQVDRVAGQRGLDPVQLTEQVKSAAQAGILGPQVVNILQLNLQLDHQKGA
>NZ_LS483441.1|WP_042016150.1|13737_16326_-|sensor-histidine-kinase-KdpD
MRDEVRADALLASLEQEHRGKLKVFLGAAPGVGKTYAMLQAVREQAREGVDILIGVVETHGRQETLALLDKLAILPRTLHLHRQQRLEEMDLDGLLARKPAIAVVDELAHSNAPGSRHEKRWQDVEELLGAGIDVYTTLNVQHLESLNDLVWQLTGVRVKETLPDQVLLEADSLVLIDLPPKELLGRLKEGKVYVPHQAKAALQSFFSLNNLTALRELAMQTAASHVEGDLQLQWQAAGKTTLPLRGKLMVCIGDEHGAALVRYGHRFAQRRQLPWLVVHIDSKGQRSPELEQALALASQLGARVLTLSSPAVADALLETAEQQQVSQLLLGKSRNPPWRRSLVQHLLKQAQGFEITLVDTEKRKPGLTLPTAGPGELRQSLLAVAIMGGTSAVVWALSHWLPPASLPMLFVLGVLATALTTSLVPAILAAVLGFVGHNLLFTFPYFSLSVASHSDLLTLFVLLIVGIAAGRLASRQRQQLVSLRETQQLGNALLSLSQGLATASSPVDVLRQGTQAIALALGQPVFALDGDYQYRAGDTQTGPGQTDKAAIDWCLAQKQSAGAHTATLNAAEAQYHHLGDDLVLGIRLASPLTSAAEHQLQALLTDIRAALARIDLNERLADSQLQAETDRMRAALLSSVSHDLKTPLATIMGAGSTLLEYGDRISAEDRIELLHSVQDEARRLHGYVQNLLDMTRIGSPDFQLKRDWVDLADLVESARRRLDSSWRQHKLLVHFDQQIPRLYVHGALIEQVLVNILDNASRYSPAGTPIEFKVMLADPDLIIDIIDIGVGIAESDRDKIFNLFYTQPVGDCGSRGTGLGLAISRAMIEVHGGRIWAFAGPNGNGTCMRISLPLALNAPAA
>NZ_LS483441.1|WP_042016147.1|13015_13699_-|response-regulator
MAHILVIDDEAAIRRFLRISLIAEGHQVSEAVGVTEGMTQYRHLNPDLVILDLGLPDGDGIQILHAIREHHANPVLVLSARDSEQEKVRLLDAGANDYMSKPFGVGEMMARIRVLLRQRVGATSGECRHFPHCGLTLDSSSHKVTLQGEEIPLSRKEFALLQALVCHPGKLVQQTQLLIDIWGPSHKEDTHYLRIVIASLRKKLGDNPQQPTLIETEAGIGYRFIGS
>NZ_LS483441.1|WP_042016145.1|11883_13011_+|multidrug-effflux-MFS-transporter
MNNRLPPRWLVVGLMMFPQIVETIYSPVLTHIATEFRVSEGQASQTLSVYFLAFAAGVVCWGRLCDLIGRRPAMLAGLLTYGAGTLLALLATQFETLLLARVIAAFGAAVGSVVTQTMLRDSYQGSDLARVFSVMGIALSLSPVLGLVSGGLLADGLGYLGVFGALLALAIGLLLMACWQLPETRPATTQRVALWPLACRMVRDTGLWRSAALVALFNTMLFGYYSLAPFLFASLGLSAGEFGYSGIVLALATLVGSLLNKRLLGRGWSPASLIRLAAALALGSGWLVWASQTSLWFLLPMMGVVVAFGLAIPNVLSQALLAYREVAGSAGALFGLGYYLLLSLGLAVAASLQDLGLLLGGCGLLALCCGWRRST
>NZ_LS483441.1|WP_042016144.1|10966_11791_-|AraC-family-transcriptional-regulator
MAFILPDHPFDPDQHDGSAIGIAAALGWHDSGRHQHQRHQLLFAQAGCMTIELDDQVCLLPPTRAAWLPAGLPHRVLMRGVVAYRSLYFQPEPELPNEMAVLAVNPLLREIIERMALWPWDKPEAEQTCTLALLKEELAQAPRESWQLPLPSDGRLTGWLQEIKQGDTLPDRLNQLAERVGASDKTIGRIFMRETGMSYQAWRQQWRLLRAMELLAETEPISRVAAALEFASDSAFIAFFRQHTGQTPLRYLNSRGESHRPNSPPPPGSPGPAA
>NZ_LS483441.1|WP_041214189.1|10803_11037_+|hypothetical-protein
MKILIATLIASSLSLNAMAAENPRPELDSAALQQEMLALQQQASHDVVAEAIHNLKPLALETLVVEASSADATHPES
>NZ_LS483441.1|WP_042016142.1|9269_10520_-|valine--pyruvate-transaminase
MEFSLFGEKFTRHAGITQLMDDLNQGLLNPDAIMLGGGNPAPIPAMLERFQAEANTLLDNGELIKAMANYDGPQGKDRFTRALAALLSKELGWEISARNIALTNGSQNAFFYLFNLLAGEFADGRKKKVLFPLAPEYIGYADSALSDDHFVAYKPTIEKLPDGQFKYHVDFESLQVGDDIGVICVSRPTNPTGNVLTDEEIEHLDQIARDKGIPLLIDNAYGVPFPGIIFSDAKPFWNANTILCMSLSKLGLPGTRCGIVIADEKIIRAITNLSGIINLAPGSLGPAITIPMIESGDIITLSEQVVKPFYQQKATFAVQLLREAIPDPRFHIHKPEGALFLWLWFENLPIHCQELYERLKAKNLLIVPGHYFFPGIDDPEWRHSQECIRLNYAQSEDLVRRGIAILADEINALYAG
>NZ_LS483441.1|WP_042016141.1|8755_9196_+|Hsp20-family-protein
MRNLDFSHLYSNAVGFERMARELEGLFDQKTSAYPPYNIEKRDDDSYLITVAVAGFDRNELELETENGTLKVKGRKVATMGERQFLHQGIAERDFELAFKLSQHVEAQGARLEHGLLTIELARELPEALKPRAIPIGKPDQLALPG
>NZ_LS483441.1|WP_042016159.1|22686_24645_-|PAS-domain-S-box-protein
MSGIFSKAVGLNGLSYRLLSYILICSTVLALLITVLQLAWDYNKDVTVIEASIGQIEASFLQPISASLWNLDEEQVKVQIEGIMNLPNMQFVMVKEMLGNSEVPLLTQGVEQPQYDISREFTLSYQGEVVGKLFVAASLEQVYQRLIEKSVLILVSQTIKTLVVSFCILVIIYYLVIRHINRIVSYAQKLSLDRLAVELTLEGRPLPRKSPDEFDTLAATLNQMRTRLNDEFTARHQAADQLQQERDFSATLINSANMVICCMEPDLNIASINPAAILLTGYHHQELLQHNWLDLFVSKEQRDELAATLADQGALEDREITMHDQQGNELVLQWTFAPFYEGPNLKYLIGFGYDITPLKKVEREITLFNEQLEGKVAERTRSLSDANDQLGKAYDDLKQAQQTLVESEKMASLGSLVAGVAHEINTPIGISVTASSYLQERVADFKQHIEAKQLSRTYLNEFTQNLDESMQLLQGNLRRASELIASFKQVAVDQSSEARYNFSLADNLHQVVVSLGYKLKKAQCEVDIQCDPKLSIYSFPGSFTQIYSNLILNSIHHGFDGWDRPRKITIQVAQQGDELVIDYSDNGRGIPPEILPRIFDPFVTSKRGQGGSGLGTHIIYNLVVQLLRGRIHCASQPGQGAQFHIRLPIQQN
>NZ_LS483441.1|WP_039040660.1|24765_27846_-|multidrug-efflux-RND-transporter-permease-subunit
MRFTDIFIKRPVLAISLSFLIALLGFQAIFKMQVREYPEVINTVITVNTSYYGASADLIQGFITQPLEQAVAQADNIDFMTSSSQLGSSTVTAYMKLNTDPNAALSDILAKVNSVRSQLPKEAEDPSVTSSTGSTTAVLYMGFTSPELNSSQITDYLERVIKPQLFTVGGVSKVDLYGGVEFALRVWLDPAKMAAFDLTSSDVMTVLNSNNYQSATGQATGYFTLFNGNAETQVGNIEELKRLVVATRDSKVIRLSDIAKVSLEKSHDIYRASANGREAVVLAINAAPTANPINIAHDVLELLPSLKRNMPSTMQVNVLYDSTIAINESIHEVIKTILEAAAIVLVVITLFLGSFRAVIIPIITIPLSLIGVVMMMDMFGFSINLMTLLAMVLAIGLVVDDAIVVLENVDRHIKEGEEPFRAAIIGTREIAVPVIAMTVTLAAVYAPIALMGGITGSLFKEFALTLAGAVFVSGIIALTLSPMMCAKMLRANEEPGKFERTVHDLLDRMTARYDAMLHAVMQKRIVVILFAVIVFASLPLLFKFIPSELAPSEDKGVMAVLGTAPSNANLDYIENTMADVNKVLDDQPEIAYSQVFSGVFNSNQAFGIASMVPWSQREASQKEVLDRVAGLVKDIPGMAITTFQFPELPGASSGLPIQFVITTPNSFESLFLIAGEMLAATQANGQFVYSDLDLNYDSATMKISIDKDKAGAYGITMQDIGITMGTMMADGYVNRIDLDGRSYEVIPQVERKFRLNPESIKGYYVRAADGKSIPLGSLIKIEVKGEPRALPHFNQLNSATIGAVPAPGVAMGDAINWFKATAEEKLPQGYRYDFMGEARQFVTEGNALYATFALALAIIFLVLAIQFESVRDPLVIMVSVPLAISGALIALAWGMATMNIYSQVGLITLVGLITKHGILICEVAKEEQLLHGLNRMQAVMQAAKVRLRPILMTTAAMIAGLIPLLYASGAGAAQRFSIGIVIVAGLAIGTLFTLFVLPVIYTFLASEHKPLPEFDESIPAKAKGGH
>NZ_LS483441.1|WP_039040661.1|27861_28968_-|efflux-RND-transporter-periplasmic-adaptor-subunit
MKKWMAIMLLIALALFGSVIGFNMFKQKKIAEFMANRPEPEFPVTAMVTKAQDWVPTIEAIGFIEPNQGVTLSSELSGTIDSIRFESGAHVKADQLLLSLDSSVEKANLNSSQARLPAARAKFERYKNLYQKNSISRDQLDDAEASYRSLEADIDSLKATIARREVRAPFSGAVGLRNVFLGQYLEPGTQIVRLEDTSVMRLRFTVPQTDISKITLGQTIKINVDAYPQTQFDGQITAIEPAVNYQSGLIQVQADIPNNDGQLRSGMFARASIILPTVKDQIVIPQSAISFTLYGENVYVIHEADGVKRAKQVVVKAGERRGNDVHVLSGIKAGDQIVLSGQVRLSNDTKVHVVENDALAVPAQTPML
>NZ_LS483441.1|WP_042016162.1|28964_29555_-|TetR/AcrR-family-transcriptional-regulator
MDKKERIFEAAHEILGEQGFYGLSIAVVAKKAKVAAGTIYRYFSDKDDLIRQLYQHTILKFHPLVMEGVQIEEVSYEQYRRLWLNIDAIFTSYPNALKCKLQYESSPLGAELERDPVIMATWAPLERFFEQGRQQGLFIDLPILVLQALSLDCVANLAQQRRVHDFELTQEQLETVIRASWNAILNPNVSITGACS
>NZ_LS483441.1|WP_041214197.1|30434_30953_+|ricin-type-beta-trefoil-lectin-domain-protein
MHHHITSLQLSVLAMAALLLGGCALQPKPEDLLMGAAPKPKAELEATLVTSGGFCVTLSEQGRLLTQPCDQQSNQSFSWDVGALQLAGDCLVAKGEDGLGMEACREESHQWLWQGDRLFNRQVSLCLDVAGRRHKPAVPLRLAECYGGANQSFEWTPSGTLLNRLVRPALAW
>NZ_LS483441.1|WP_042016195.1|31023_31827_-|Cof-type-HAD-IIB-family-hydrolase
MFKVVVSDLDGTLLNGQHQISSRTRDTLHRLVDQGVKFVVATGRHHVDVRSIRDALGLDIYLITSNGAVVHDKQDQLVYNQALPSTVAAELIAMERDPSIHINVYYGDEWLVEEELPWLLQFHHDSGFSYRLADLANHPKDRVNKVFYIGDHDKLLKIEAHLNQQYGDRINVTFSLPDCLEVMHAGVHKGNAVRAVLEQHGLEMSQAVAFGDGMNDFEMLSMVGRGVVMGNAHDRLKQALPEHEQTLTSDEDGVAVYLEKLFASQTR
>NZ_LS483441.1|WP_042016163.1|31930_32971_-|alpha/beta-fold-hydrolase
MKLMSPALLALTLFSAGALAVSNPYQLTTEADVPALYQQTLPDFWRQHAVEGEFQGKDGVTLRYAALRQPKIDRAILIVNGRVESYLKYQELAWDLWRQGYSLYLIDHRGQGMSDRMLADKEKGYVDQFDDYVADLKQFHDEVIAQDQPAKLFLLAHSMGGAISARYLERWPNDIQAAVLSSPMMGINLGGLPKWLAKGLAATIGTVGGWVGEPPYGPGQGPYEDHGFADNELTHSTARYQAFRQIYEQHPQVRLGGATAHWIHQAITGSDAAVADAGTIKTPLLLLQAGEDSVVDNAAQEAFCAKAQCDGSKPLRIEGAWHELFIEADPQRQAALNATLAFFARY
>NZ_LS483441.1|WP_042016165.1|32967_33630_-|CatB-related-O-acetyltransferase
MNSPFGSWLESQVIRDHLSNPNIEAGDYSYYSGYYHGKPFEDHCVRYLLGDGSTRETWESGIWGEVDRLLIGKFCSIGSGATFLLAGNQGHRMEWVSTFPFDPGTFGEGVQSGFQRKGDTRVGNDVWIGSEAMIMPGITIGDGAVIATRAVVTRDVEPYTIVGGNPAKPIRRRFSDEQIALLQEMRWWNWPLPRLQAAMPLLCSGDIEGLYQHWQQESAS
>NZ_LS483441.1|WP_042016168.1|33632_34361_-|tRNA-(guanosine(18)-2'-O)-methyltransferase-TrmH
MTPERFKRISDMLAQRQLDLTVCMEEVHKPHNLAAIVRTADAIGIHRVHAVWPKSWIHKRKGTARGSQNWVDVKLHPDIGSAVTELKASGMQILATHLSDSSVDFRAIDYTRPTAILVGQEKHGIGEEALALADHHIVIPMVGMVQSLNVSVAAAAILYEAQRQRELAGCYQRGCPLTPEEQNTILFEGGYPVYAQLCKEKEMPYPQLGPAGEILADEQWWQQMQLTRKGWAAQQDEQLQEQ
>NZ_LS483441.1|WP_039040667.1|34468_36586_-|bifunctional-GTP-diphosphokinase/guanosine-3',5'-bis-pyrophosphate-3'-pyrophosphohydrolase
MYLFENLKEIASSYLPPEQVEKLRQAYVVARDAHQGQMRSSGEPYITHPVAVARILGDMRLDHETLMAAVLHDVIEDTPVTKDDLAEQFGNAVAELVSGVSKLDKLKFRDRKEAQVENFRKMMMAMTQDIRVILIKLADRTHNMRTLGSLRPDKRRRIARETLEIFAPIANRLGIHTMKNELEELGFEALYPMRSRVLRESVRRARGNRREIIDSIQSEIEGRLREAGIDAQVSGREKNLFSIYNKMEKKELQFHEVMDIYAFRVRVKDIDTCYRVLGQMHSLYKPRPGRFKDYIAIPKTNGYQSLHTSLVGPHGVPVEVQIRTEFMDQMADKGVAAHWAYKQDGDSSGTTAQIRAQRWMQSLLELQQSAGSSFEFIEGVKTDLFPDEIYVFTPEGRIMELPAGATPVDFAYTVHTDIGHACVGSRVDRHPYPLSSPLHSGQTVEIITAPGARPNAAWLNFVVTTKARSKIRQFLKNLRTEESVVLGRRLLNHALGAKNIEDIPEARVKQVLADTKHENLQGLLADVGLGNAMSVMVARRMLGDELPPEEQPKSTSKKMPIKGADGMLVTFANCCRPIPGDAIIAHISPGKGLVIHQESCRNIKGYSREPDKYLPVQWEVDKEQEQEFRTGISIEIVNHQGALAELANVIAATGANIHAISTEEKDGRVYVVTLLITTKSRIHLANIMRKIRVMPNVLRVSRQKN

Crispr_ID: NZ_LS483441_2

• CRISPR_ID: NZ_LS483441_2
• CRISPR_location: 518354-518553
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_LS483441_2

Consensus_repeat	Method
CTTAGCTCAGTCGGTAGAGCAACGGACTGATAATCCG	PILER-CR

spacers of NZ_LS483441_2

>2.1|518391|42|NZ_LS483441|PILER-CR
TAGGTCACCAGTTCGATTCCGGTAGCCGGCACCATTTGCCCA
>2.2|518470|47|NZ_LS483441|PILER-CR
CGTGTCGGCGGTTCGATTCCGTCTCTGGGCACCACGAATAATTCCTC

CRISPR arrays and Neighbor proteins around NZ_LS483441_2

CRISPR arrays

The CRISPR arrays of NZ_LS483441_2

>merge|NZ_LS483441|2|518354-518553|PILER-CR
CTTAGCTCAGTAGGTAGAGCAACTGACTTGTAATCAGTAGGTCACCAGTTCGATTCCGGTAGCCGGCACCATTTGCCCAGATAGCTCAGTCGGTAGAGCAGGGGATTGAAAATCCCCGTGTCGGCGGTTCGATTCCGTCTCTGGGCACCACGAATAATTCCTCCTTAGCTCAGTCGGTAGAGCGACGGACTGTTAATCCG

>NZ_LS483441|2|1|518354-518553|PILER-CR
CTTAGCTCAGTAGGTAGAGCAACTGACTTGTAATCAG	TAGGTCACCAGTTCGATTCCGGTAGCCGGCACCATTTGCCCA
GATAGCTCAGTCGGTAGAGCAGGGGATTGAAAATCCC	CGTGTCGGCGGTTCGATTCCGTCTCTGGGCACCACGAATAATTCCTC
CTTAGCTCAGTCGGTAGAGCGACGGACTGTTAATCCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LS483441.1|WP_029314835.1|520434_521034_+|YIP1-family-protein	unknown	unknown	gnl|CDD|369140
NZ_LS483441.1|WP_042015126.1|516458_516968_-|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl|CDD|223872
NZ_LS483441.1|WP_042015128.1|518853_520197_+|two-pore-domain-potassium-channel-family-protein	unknown	unknown	gnl|CDD|369572
NZ_LS483441.1|WP_042015117.1|508498_510070_+|cyclic-diguanylate-phosphodiesterase	unknown	unknown	gnl|CDD|238923
NZ_LS483441.1|WP_042015131.1|525545_527210_-|alpha,alpha-phosphotrehalase	unknown	unknown	gnl|CDD|182849
NZ_LS483441.1|WP_080767911.1|523407_524283_-|EamA-family-transporter	unknown	unknown	gnl|CDD|182525
NZ_LS483441.1|WP_039039721.1|527298_528729_-|PTS-trehalose-transporter-subunit-IIBC	unknown	unknown	gnl|CDD|182896
NZ_LS483441.1|WP_042015132.1|528915_529863_-|HTH-type-transcriptional-regulator-TreR	unknown	unknown	gnl|CDD|181905
NZ_LS483441.1|WP_029314837.1|513271_514399_+|GTP-binding-protein	unknown	unknown	gnl|CDD|223597
NZ_LS483441.1|WP_042015130.1|521861_523355_+|histidine-type-phosphatase	unknown	unknown	gnl|CDD|366031
NZ_LS483441.1|WP_042015123.1|514460_515849_+|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl|CDD|182502
NZ_LS483441.1|WP_039039724.1|524379_524838_+|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224439
NZ_LS483441.1|WP_042015124.1|515858_516341_-|YbaK/EbsC-family-protein	unknown	unknown	gnl|CDD|239824
NZ_LS483441.1|WP_029314833.1|524925_525546_-|sugar-O-acetyltransferase	unknown	unknown	gnl|CDD|100047
NZ_LS483441.1|WP_010675798.1|516967_517339_-|dihydroneopterin-aldolase	unknown	unknown	gnl|CDD|224456
NZ_LS483441.1|WP_029314836.1|517510_518173_+|glycerol-3-phosphate-1-O-acyltransferase-PlsY	unknown	unknown	gnl|CDD|234691
NZ_LS483441.1|WP_042015118.1|510066_510984_-|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|182990
NZ_LS483441.1|WP_042015120.1|511060_511678_+|LysE-family-transporter	unknown	unknown	gnl|CDD|273358
NZ_LS483441.1|WP_039039727.1|521145_521478_-|hypothetical-protein	unknown	unknown	gnl|CDD|176508
NZ_LS483441.1|WP_042015122.1|511793_513200_+|FAD-binding-protein	unknown	unknown	gnl|CDD|281959

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_LS483441.1|WP_029314835.1|520434_521034_+|YIP1-family-protein	gnl|CDD|369140	pfam06930, DUF1282, Protein of unknown function (DUF1282). This family consists of several hypothetical proteins of around 200 residues in length. The function of this family is unknown although a number of family members are thought to be putative membrane proteins.	7.15334e-35
NZ_LS483441.1|WP_042015126.1|516458_516968_-|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl|CDD|223872	COG0801, FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism].	2.4894e-43
NZ_LS483441.1|WP_042015128.1|518853_520197_+|two-pore-domain-potassium-channel-family-protein	gnl|CDD|369572	pfam07885, Ion_trans_2, Ion channel. This family includes the two membrane helix type ion channels found in bacteria.	8.91638e-08
NZ_LS483441.1|WP_042015117.1|508498_510070_+|cyclic-diguanylate-phosphodiesterase	gnl|CDD|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	2.58278e-86
NZ_LS483441.1|WP_042015131.1|525545_527210_-|alpha,alpha-phosphotrehalase	gnl|CDD|182849	PRK10933, PRK10933, trehalose-6-phosphate hydrolase; Provisional.	0
NZ_LS483441.1|WP_080767911.1|523407_524283_-|EamA-family-transporter	gnl|CDD|182525	PRK10532, PRK10532, threonine and homoserine efflux system; Provisional.	1.64799e-80
NZ_LS483441.1|WP_039039721.1|527298_528729_-|PTS-trehalose-transporter-subunit-IIBC	gnl|CDD|182896	PRK11007, PRK11007, PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional.	0
NZ_LS483441.1|WP_042015132.1|528915_529863_-|HTH-type-transcriptional-regulator-TreR	gnl|CDD|181905	PRK09492, treR, HTH-type transcriptional regulator TreR.	0
NZ_LS483441.1|WP_029314837.1|513271_514399_+|GTP-binding-protein	gnl|CDD|223597	COG0523, COG0523, Putative GTPases (G3E family) [General function prediction only].	6.02238e-88
NZ_LS483441.1|WP_042015130.1|521861_523355_+|histidine-type-phosphatase	gnl|CDD|366031	pfam00328, His_Phos_2, Histidine phosphatase superfamily (branch 2). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches.The smaller branch 2 contains predominantly eukaryotic proteins. The catalytic functions in members include phytase, glucose-1-phosphatase and multiple inositol polyphosphate phosphatase. The in vivo roles of the mammalian acid phosphatases in branch 2 are not fully understood, although activity against lysophosphatidic acid and tyrosine-phosphorylated proteins has been demonstrated.	8.98294e-12
NZ_LS483441.1|WP_042015123.1|514460_515849_+|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl|CDD|182502	PRK10504, PRK10504, putative transporter; Provisional.	6.91802e-159
NZ_LS483441.1|WP_039039724.1|524379_524838_+|Lrp/AsnC-family-transcriptional-regulator	gnl|CDD|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	7.23399e-39
NZ_LS483441.1|WP_042015124.1|515858_516341_-|YbaK/EbsC-family-protein	gnl|CDD|239824	cd04332, YbaK_like, YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze mischarged cysteinyl-tRNA(Pro)'s, thus helping ensure the fidelity of translation. Organisms whose ProRS lacks the INS domain express an INS homolog in trans (e.g. YbaK, ProX, or PrdX).	3.55053e-25
NZ_LS483441.1|WP_029314833.1|524925_525546_-|sugar-O-acetyltransferase	gnl|CDD|100047	cd03357, LbH_MAT_GAT, Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6 position of the nonreducing end glucosyl moiety. GAT specifically acetylates galactopyranosides. Furthermore, MAT shows higher affinity toward artificial substrates containing an alkyl or hydrophobic chain as well as a glucosyl unit. Active MAT and GAT are homotrimers, with each subunit consisting of an N-terminal alpha-helical region and a C-terminal left-handed parallel alpha-helix (LbH) subdomain with 6 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X).	1.40184e-100
NZ_LS483441.1|WP_010675798.1|516967_517339_-|dihydroneopterin-aldolase	gnl|CDD|224456	COG1539, FolB, Dihydroneopterin aldolase [Coenzyme metabolism].	2.45454e-42
NZ_LS483441.1|WP_029314836.1|517510_518173_+|glycerol-3-phosphate-1-O-acyltransferase-PlsY	gnl|CDD|234691	PRK00220, PRK00220, glycerol-3-phosphate 1-O-acyltransferase PlsY.	1.45172e-92
NZ_LS483441.1|WP_042015118.1|510066_510984_-|LysR-family-transcriptional-regulator	gnl|CDD|182990	PRK11139, PRK11139, DNA-binding transcriptional activator GcvA; Provisional.	6.96859e-70
NZ_LS483441.1|WP_042015120.1|511060_511678_+|LysE-family-transporter	gnl|CDD|273358	TIGR00949, Uncharacterized_membrane_protein_YahN, The Resistance to Homoserine/Threonine (RhtB) Family protein. [Transport and binding proteins, Amino acids, peptides and amines].	3.11486e-45
NZ_LS483441.1|WP_039039727.1|521145_521478_-|hypothetical-protein	gnl|CDD|176508	cd08565, GDPD_pAtGDE_like, Glycerophosphodiester phosphodiesterase domain of putative Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in putative Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase (pAtGDE, EC 3.1.4.46) and its uncharacterized homologs. Members in this family show high sequence similarity to Escherichia coli GP-GDE, which catalyzes the degradation of glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.	0.00145366
NZ_LS483441.1|WP_042015122.1|511793_513200_+|FAD-binding-protein	gnl|CDD|281959	pfam04030, ALO, D-arabinono-1,4-lactone oxidase. This domain is specific to D-arabinono-1,4-lactone oxidase EC:1.1.3.-, which is involved in the final step of the D-erythroascorbic acid biosynthesis pathway.	1.76612e-45

Protein sequences

>NZ_LS483441.1|WP_029314836.1|517510_518173_+|glycerol-3-phosphate-1-O-acyltransferase-PlsY
MTALTILMIILAYLGGSLSSAVLVSRITGLPDPRDHGSHNPGATNVLRLGGRMAALIVLLLDVLKGMAPVYLAWYLQIKPVYLGFIGVAACLGHMYPLFFHFRGGKGVATALGTMLPIGFAMGGAVITTWLLVLLVSGYSSLASIVTVLLTPLFTYLLKPEYTLPVSLLSCLILIRHHENITRLLKGEESRLWGRRGAVPPAEVMKMDDAAQKRDERDEK
>NZ_LS483441.1|WP_010675798.1|516967_517339_-|dihydroneopterin-aldolase
MDKVFIRGLEVLTTIGVYEWEKGIRQKLCFDLEMGFDNRPAAATDDINLALDYATLSRKICDHAQGKIVELVETMAEQVAALVLEDERVQWVKVTLTKPGAVPNAAGVGVEILRHRTPAASAN
>NZ_LS483441.1|WP_042015126.1|516458_516968_-|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MTRIYISLGSNIDRERHIRAGLDALHAEFGELQVSRVFESEAVGFNGRPFYNLVVGADTELPLATLCQRLRAMEFAHGREPDAKKFAPRTLDLDLLLYGELVCETPLVLPRGEILTNAFVLWPLAELAPTFRHPIDGRTIGELWAGYDKASQRLDPIPFHWEAGELQHH
>NZ_LS483441.1|WP_042015124.1|515858_516341_-|YbaK/EbsC-family-protein
MPLDAIHDFNRQLLTDLPHQHFEHEPILDYATDERVKARLGWQAEFSKTLFLKFKDGRFALLLTHRDGRLDSKAVKAALGAKPSICTADEMQTEIGCLPGAVCPFLPRADIPLLVDPVLMNHHAFTWTPGHPEQTFLLETTHLAGLLARLPCDVSYLPAP
>NZ_LS483441.1|WP_042015123.1|514460_515849_+|DHA2-family-efflux-MFS-transporter-permease-subunit
MPDSSPMVTPAQRKWLPWLTAVGFFMQTLDGTILNTALPSMAEALGESPLQMQSVIIAYMLTVALLIPASGWLADRFGTRRVYLVAILLFTLGSLACAIANTLPMLVIARVLQGVGGALLMPIGRLAVLRVYSKHELLRVMSFVTIPGLLGPLIGPALGGWLVEVASWHWVFLINLPVGLLGFVASWHFMPDLRQHTARFDWQGFVLFSAGMVLVSVGLQGLGEHSISTGWALFAVLFGLAAMASYWLYAATAEQPLFSLALFKTSTFAIGIWGNLFARLGSGAMPFLTPLFLQLGLGFSPSKAGMTMIPTVIGAMLTKTLVNKLIPRIGYRRILIGNTLALGAMIASFYFIDNQVPHGVLLVWLAVFGAINSLQFSAMNTLTLQDLSSEHASSGNGLLSVVMQLSMSLGVAIAASLLGLFSIGQPEESGRWLEGFHLTYLCIGLMSMLAALIFAQLAREKR
>NZ_LS483441.1|WP_029314837.1|513271_514399_+|GTP-binding-protein
MTDMQDTRIPVTLLTGFLGSGKTTLLNHWVKQPELGECAVLINEFGSVGLDHHLVQQVDEQVVLLDSGCICCSVQGSLVEALQGLFMKAIQRKIKPFKRLIIETTGLADPAPVLFTLREEGFIAQRYRFDGTVTVVDAGHIEQQLAAQYEAVKQVALADLLVVSKGDLVDEETLARVEAQLAALNPAAPIQRVSNGVLSPAVLEKLGAYNEAAGRDVRQLLAWLRTESPKQGLASPMQPKMTPFAAKVGTAAPTRFEHGNIESFSLRIGEPLKPSRLLAAIDAVQAQYGDALLRLKGILQLEGESQPVVIHGVHGQLYPLQALGEWPEGKAQSRLVFIVKSQDRVGIEQLFLSTLKAPEPSLEEHLKAMLGQPDA
>NZ_LS483441.1|WP_042015122.1|511793_513200_+|FAD-binding-protein
MTVRFQAFHSIKAIGNREVLFNWSRTNPLGALDQVWRPTTRDELQQLLREYPERKLRLIGSGLSFEPIHSVYAEGSQALLVDLHHLRGQLDKTADTVTYLAGTPLDTVYADLIAMDRMLPASPGVIGIQTLGGALSTGTHGQGLHQSALCDAVEAMTVMLANGEIIRVDRSDPRFGAFVMGMGMLGILLDVTLNTVPNRIMRCTKFTTDYPFLLEHNERLNREHAFVKSWWFAWTGESHIWLVDPASDDEVARYRAGGSEPLVLEGDMDERMNLALNATIDATLQKMARDTKDEARAGEHFETVRRFKDASDLVGNVYQILCKGIPAPQINCEVAVPLERMGEALEILQAWQEANPGVLHYPFILRCTGPSVAWLSAAHDKSVCWIGFLVYLAADGTFVGGSMEQMRELQQLLVPLGGIPHFGKHLAMDLYDFPALLPRWHDFLALKRELDPHGRFENRWLGDLFANR
>NZ_LS483441.1|WP_042015120.1|511060_511678_+|LysE-family-transporter
MTELLAVVAITLFAVISPGPDFAMVSRNSLLLSRRTGVLTAIGIAAGVCVHVTYTLLGVGLLIQQSLWLFNLIKLAGAAYLIFLGIKMLRAKPAADEESICQPALSSLGALRTGFLTNVLNPKTTIFIVSLFMQVVQPQTPLAVQIGYGAFIALAHALWFGAVALFFSTPAVRDRLLAVRHWLDRVFGGLLVGFGMLLALTQQTR
>NZ_LS483441.1|WP_042015118.1|510066_510984_-|LysR-family-transcriptional-regulator
MNGEKNSQKTLSLPSLTALRCFEVAARTEHFGRAADELHLTHGAISRAVRLLEEDLGVMLFERRQRRVFLTDAGERFYQAVREGLGSIRQTAQALRQQSRPQSLVLSCEPTLLMRWLIPRWPAFQALHPELDVHLMAGGGALSFGSGIDLAIRRNDFDWPEDLHSQLLFEELTGPVCQPGKVAQFFEPRGDVQALRPTAPRLHTKTRPGAWLEWQQHAGMPADEEVPGQTFEHFYFSLQAAVAGLGVAIGPYRQVCDDIEAGLLVAPLGFVPDGTGYHLLAPAPPEPGSPHDILVNWLHSLVGAA
>NZ_LS483441.1|WP_042015117.1|508498_510070_+|cyclic-diguanylate-phosphodiesterase
MFLFRIDLARMKWRLGCALLVLALPLVVGGWMVHDSYEQELKNDASASASKARTLLERMLDQAERANLEVLPLAGRPCSDNLLLLRKRVALEPFLRSINLVRQGIINCTSLFGPAREVDDGSRYTDRKLLLMSGNLVRKNHPLLVVRQERGRDAALSAIDSSQLSFMLTLSSDPSELFLQVGSAWLDESGHFQSDPPKLHSKFALILASQRYPFTIHAGYAMPIYWRALWEARHLQLIWLGASSLVLSLLVWWLLGRPGALADELRRGLRAREFVPYLQPLIASKGGKMVGAEVLMRWQHATEGLIRPDLFIPQAEESGLIVPMTVNLMKTVAKTLHPVQEQLPEAFHISFNISAIHCRDLSLVAECRDFLGHFVPGRVVLVLELTERELLVTSPQTLSLFRQLDEMGVQLAIDDFGTGHSSLIYLQQFHVDYLKIDRSFIGRIGTESLSEHIVDNVIDLGGRLGLSLVAEGVETEQQAAYLRGKGVQYLQGYLFARPMPIRQFCRELTAGEIQVAAGRTAQG
>NZ_LS483441.1|WP_042015128.1|518853_520197_+|two-pore-domain-potassium-channel-family-protein
MNATELWQLSPEQFNEWRRENDYPRIWALLVASLPHFDDWMAEQKIEKSVIFQIGIARFISSRCVLSLCVYMSDDKVRLYESASSALESLRKSGLIRSETRFEPYSMWLAGKHGNDEVKRVQSLLSVSENNKGEAQVLGKHRLLNIGGVTLKSPIISGRLLDFTCLDELSLDGAVNNSKVYLWHCSAKGVRVNGGVIGLDLFDSLLWDHRAWAKKRELALEDGVFQDFTIECEEIRFHSSRAVLKNFSVSAKNFDATMEHTNLDKVEVVYNDNGRIDHNEASKLYRNAKRLFSSVGDTVDAGECYYKEKLHEMKSLASPRELYRERWLRSGPMTKCWLSLLCYLKCAGKFISFITWGFGERPIRSLLMSMGVILLATLTYFLAPESATHGHLGRSLYFSIVTFVTLGYGDISQTSSPLQLLSAIEAFCGMFLTGLFLAGFASKTKQY
>NZ_LS483441.1|WP_029314835.1|520434_521034_+|YIP1-family-protein
MILNHLWGLYAHPHTEWHTIDERHDSFRNSLTHILLVALIPPICAYYSAVHIGWSIGVGDPITLTANSAFKLSVAMYVTLIIGVLALSYLVHWMGHTFGSDPSYTTSLELAAYTSTPLFMVGFSAFFPHLWFVMLIGLVGLTYSVYLLYIGVPILMHITKEQGFIYASSVVTVGLVLLVCVLAATAILWGSGFGPVFTQ
>NZ_LS483441.1|WP_039039727.1|521145_521478_-|hypothetical-protein
MNMKNVIKMLAVAGLMSAGVAQASVPADFNATPGVLFVNWHASAAMAGKANPMLEVRDESGDLVASVHANLMGTQQVQIPSRAQGNLTVSLGDQSSDYRIPFGIGSGNPR
>NZ_LS483441.1|WP_042015130.1|521861_523355_+|histidine-type-phosphatase
MTMFRVSSLAACVAATLLSGCHSGNDSSSPAVGDYQYSTKAVYAARQAMNSYEVAPEGFSPVFTELVARHGSRSLSSPKYDVLTKLVWEEAARQGALTELGQRLGAKVDAVTAANQTLGYGLLSALGKEEHANLATRLAERLPTLLTTESTPLCLKVETSGKDRANESAYFFMQSLAKRASLVTDSPDCYVSQENPSEIDKGLRNKFELYFHKTEPQGEYIRYLPTFQAYQAFVGDEDNGVAPAPELTEALDALKALPRTRVMAREMLERLYSKAFVDELAAGVDYVAVNPEDGGKTHVRDEVDAALMLYNLFIIGPGMIREAQAQGGSWDLEQFITPEESAWFSYLSDAEDFYEKGPSLASQSATYAVAQPLLDGLFNEVQTQVVEEAGEHVAKLRFAHAETLIPLAALMKLEGSRQSAQPGVLMSQENNEWRGGWVSPYAANIQWDVYRNEAGRVLVKMLYNEKELAFKAGCAPIAVGSFFYDFGELKRCYDYSS
>NZ_LS483441.1|WP_080767911.1|523407_524283_-|EamA-family-transporter
MNTMQPNPNALSSLLAVLLAMLSITLGASLAKSLFPLLGAAGTTLFRLGCAALLLSLVFRIWRAPLDRRTLLSAIPYGLSLGAMNLLFYLAIARIPLGVALAIEFIGPLTVALLSSRHRADFIWLILAIAGLLLLLPLRATQQAIDPLGAALALGAGLFWGLYMLTGKRAGALLGAQAPALGMWVGTLLVLPFGLEGAIEASFTVPVILTIIGVGLLSSAIPYSFEMFALRRLPLKSYGILTSGEPAMGALMGLVWLGEQLPPSQWLGIAAIIAASMGTTWQAGRRQAGSA
>NZ_LS483441.1|WP_039039724.1|524379_524838_+|Lrp/AsnC-family-transcriptional-regulator
MTDKFDLLILAELQQDARLPTPELAHRVGLSAPACYRRVRALRESGLIEREVALVAPSTMGWPITMLVLVTLERDHGRIVDEMIASLQREPEVMDLWYVTGEQDFVLQVAARDMQSYEQFTRRVLHARDQVRSFKTLVVMGQHKRCGALLPG
>NZ_LS483441.1|WP_029314833.1|524925_525546_-|sugar-O-acetyltransferase
MTDATTVQRPAVRGPEWQKMVAGAPYDAGDPELRAAREQCRALLGELNRERTDAPGWDERLTRLLGGRAERCFITPPFFCDYGANIFVGENFYANFNCTILDVCEVHIGDNVLLAPGVQIYTATHPVAVAPRIKGVEFGKPVRIGNNVWIGGSVVICPGVTIGDNSVIGAGSVVTRDIPAGVVAVGNPCRVLRPMTAEELAPGEPG
>NZ_LS483441.1|WP_042015131.1|525545_527210_-|alpha,alpha-phosphotrehalase
MTQTPWWQSAVIYQIYPKSFQDSGARGTGDLKGIMARLDYLKTLGVDALWLTPVYVSPQVDNGYDIADYLNIDPAYGTMSDFEALLAAAHARGIRIVMDIVVNHTSTEHAWFKSALGDKHSPYRDYYIWKDPVDGGVPNNWQSKFGGSAWELDPATGQYYLHLFAREQADLNWENPAVRAEVKKIIHFWAKKGVDGFRLDVINLISKDQAFPDDEVGDGRRFYTDGPRIHEFLQDVSRDVFAPVGAMTVGEMSSTSLEHCQRYGALDGSELSMVFNFHHLKVDYPGGDKWTKAPFDFLELKRIFNHWQSGMHGKGWSALFWCNHDQPRIVSRFGDEGEHRVVAAKMLASTLHGLQGTPYIYQGEEIGMTNPGYQCINDYQDVESRNIFAIKQAEGISEAEILAILGAKSRDNSRTPMQWSAASNAGFTSGTPWLKPAANYSEINAEAALADQHSVFWHYRDLIALRKAYPIFTQGDYQELLTGHPQIWAYVRRANGQTLLVVSNFYGKPAAFELPAELAGGKGQLLLGNYPDSPARPQSCKLRPYESLIWLMEQ
>NZ_LS483441.1|WP_039039721.1|527298_528729_-|PTS-trehalose-transporter-subunit-IIBC
MSKVNTQHLAQLIERIGGKENITTVSHCLTRLRFVLADPAKADPKAIETIPSVKGSFTQGGQFQVVIGNEVDQWYKALTQEIGVSGGSKEAAKQAARHNMNPLERGISHLAEIFVPLLPAIITGGLILGFRNVIGDIKMFDDGTHTLTEISQFWAQVHAFLWLLGEAIFHFLPVGVCWSAVKKMGGSEILGIVLGITLVSPQLMNAYGIGQQTPEVWDFGLFVIQKVGYQAQVIPALLAGVFLAWVETSLKRIIPAYLYLVIVPFISLLLAVIVAHALIGPFGRWIGDGVGFAAKAAMTGSFAPIGAALFGFLYAPLVITGIHHTTNAVDLQLMQSMGGTPIWPLIALSNIAQASAVVGIILISRKENEREISVPAAISAYLGVTEPAMYGINLKYKFPMLCAMVGSSCAALICGFAGVMANGIGVGGLPGILSIQPQYWGIYAIAMLVAIVVPALLTLLVYKRQQAAGKLDLATA
>NZ_LS483441.1|WP_042015132.1|528915_529863_-|HTH-type-transcriptional-regulator-TreR
MEKKLTILDIARLSGVGKSTVSRVLNQDPKVNAQTRARVESVIAQHGFVPSKSARAMRSQSQQVVGIVVSRLDSSSENQAVRGMLETLYQRGYDAVLMESKFSPAKVSEHLAVLERRGVDGIILFAFNDLDYAAMAPLREKLVLMARERPGFSSVCFDDDGAVRAVLTHLGERGLTEVAYLGVERSDLTTGLRRHQAYLDYCREQGRTPRSALGDLGLQSGYRLAAELLTPTTQAMVCASDTLAIGAAKYLQEQGRTDILVSGLGSNPMLTFLFANTLSLDFGYKDAGILAARQLLDQIEEGQPPRATIAPCQPL

Crispr_ID: NZ_LS483441_3

• CRISPR_ID: NZ_LS483441_3
• CRISPR_location: 1407231-1407322
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_LS483441_3

Consensus_repeat	Method
TCGACGGCGTCCACACCGTTGTCGTCCAC	CRISPRCasFinder

spacers of NZ_LS483441_3

>3.1|1407260|34|NZ_LS483441|CRISPRCasFinder
GCTGCCATCGCCTCGACGCTTGTTGCCATTGGCG

CRISPR arrays and Neighbor proteins around NZ_LS483441_3

CRISPR arrays

The CRISPR arrays of NZ_LS483441_3

>merge|NZ_LS483441|3|1407231-1407322|CRISPRCasFinder
TCGACGGCGTCCACACCGTTGTCGTCCACGCTGCCATCGCCTCGACGCTTGTTGCCATTGGCGTCGACGGCGTCCACACCGTTGTCGTCCAC

>NZ_LS483441|3|2|1407231-1407322|CRISPRCasFinder
TCGACGGCGTCCACACCGTTGTCGTCCAC	GCTGCCATCGCCTCGACGCTTGTTGCCATTGGCG
TCGACGGCGTCCACACCGTTGTCGTCCAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LS483441.1|WP_041214786.1|1418795_1419926_-|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|225406
NZ_LS483441.1|WP_042016261.1|1403751_1404501_-|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	unknown	unknown	gnl|CDD|237729
NZ_LS483441.1|WP_010673618.1|1421479_1422091_-|high-frequency-lysogenization-protein-HflD	unknown	unknown	gnl|CDD|234690
NZ_LS483441.1|WP_042015820.1|1413512_1416830_-|mechanosensitive-channel-MscK	unknown	unknown	gnl|CDD|236892
NZ_LS483441.1|WP_042016262.1|1402590_1403670_-|FUSC-family-protein	unknown	unknown	gnl|CDD|224208
NZ_LS483441.1|WP_010673615.1|1416979_1418392_-|pyruvate-kinase-PykF	unknown	unknown	gnl|CDD|181699
NZ_LS483441.1|WP_042015825.1|1411727_1412726_-|beta-propeller-fold-lactonase-family-protein	unknown	unknown	gnl|CDD|182912
NZ_LS483441.1|WP_042016260.1|1404497_1405112_-|molybdenum-cofactor-guanylyltransferase	unknown	unknown	gnl|CDD|234725
NZ_LS483441.1|WP_042016259.1|1405333_1407043_+|NAD-dependent-malic-enzyme	unknown	unknown	gnl|CDD|237414
NZ_LS483441.1|WP_039039924.1|1410736_1411699_+|IS1595-family-transposase	unknown	unknown	gnl|CDD|372298
NZ_LS483441.1|WP_042015799.1|1395874_1396249_+|hypothetical-protein	unknown	unknown	unknown
NZ_LS483441.1|WP_042016266.1|1398398_1398863_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NZ_LS483441.1|WP_041213272.1|1408500_1409739_+|uracil-xanthine-permease	unknown	unknown	gnl|CDD|225142
NZ_LS483441.1|WP_042015823.1|1412783_1413392_-|LysE-family-translocator	unknown	unknown	gnl|CDD|224199
NZ_LS483441.1|WP_042016267.1|1397882_1398278_+|DoxX-family-protein	unknown	unknown	gnl|CDD|311556
NZ_LS483441.1|WP_042016265.1|1399065_1400361_+|PAS-domain-S-box-protein	unknown	unknown	gnl|CDD|206779
NZ_LS483441.1|WP_042016257.1|1409883_1410624_+|prolyl-oligopeptidase-family-serine-peptidase	unknown	unknown	gnl|CDD|223489
NZ_LS483441.1|WP_042016264.1|1400505_1401063_+|DUF3332-domain-containing-protein	unknown	unknown	gnl|CDD|371739
NZ_LS483441.1|WP_042014264.1|1420078_1421449_-|adenylosuccinate-lyase	unknown	unknown	gnl|CDD|236452
NZ_LS483441.1|WP_042016263.1|1401147_1402521_+|HD-domain-containing-protein	unknown	unknown	gnl|CDD|225116

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_LS483441.1|WP_041214786.1|1418795_1419926_-|cupin-domain-containing-protein	gnl|CDD|225406	COG2850, COG2850, Uncharacterized conserved protein [Function unknown].	2.73614e-121
NZ_LS483441.1|WP_042016261.1|1403751_1404501_-|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	gnl|CDD|237729	PRK14491, PRK14491, putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional.	8.53041e-81
NZ_LS483441.1|WP_010673618.1|1421479_1422091_-|high-frequency-lysogenization-protein-HflD	gnl|CDD|234690	PRK00218, PRK00218, lysogenization regulator HflD.	2.31089e-111
NZ_LS483441.1|WP_042015820.1|1413512_1416830_-|mechanosensitive-channel-MscK	gnl|CDD|236892	PRK11281, PRK11281, mechanosensitive channel MscK.	0
NZ_LS483441.1|WP_042016262.1|1402590_1403670_-|FUSC-family-protein	gnl|CDD|224208	COG1289, COG1289, Predicted membrane protein [Function unknown].	5.61907e-25
NZ_LS483441.1|WP_010673615.1|1416979_1418392_-|pyruvate-kinase-PykF	gnl|CDD|181699	PRK09206, PRK09206, pyruvate kinase PykF.	0
NZ_LS483441.1|WP_042015825.1|1411727_1412726_-|beta-propeller-fold-lactonase-family-protein	gnl|CDD|182912	PRK11028, PRK11028, 6-phosphogluconolactonase; Provisional.	4.48467e-125
NZ_LS483441.1|WP_042016260.1|1404497_1405112_-|molybdenum-cofactor-guanylyltransferase	gnl|CDD|234725	PRK00317, mobA, molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed.	4.6362e-88
NZ_LS483441.1|WP_042016259.1|1405333_1407043_+|NAD-dependent-malic-enzyme	gnl|CDD|237414	PRK13529, PRK13529, oxaloacetate-decarboxylating malate dehydrogenase.	0
NZ_LS483441.1|WP_039039924.1|1410736_1411699_+|IS1595-family-transposase	gnl|CDD|372298	pfam12762, DDE_Tnp_IS1595, ISXO2-like transposase domain. This domain probably functions as an integrase that is found in a wide variety of transposases, including ISXO2.	5.3668e-13
NZ_LS483441.1|WP_042016266.1|1398398_1398863_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.29582e-12
NZ_LS483441.1|WP_041213272.1|1408500_1409739_+|uracil-xanthine-permease	gnl|CDD|225142	COG2233, UraA, Xanthine/uracil permeases [Nucleotide transport and metabolism].	1.71056e-114
NZ_LS483441.1|WP_042015823.1|1412783_1413392_-|LysE-family-translocator	gnl|CDD|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	1.06195e-27
NZ_LS483441.1|WP_042016267.1|1397882_1398278_+|DoxX-family-protein	gnl|CDD|311556	pfam07681, DoxX, DoxX. These proteins appear to have some sequence similarity with pfam04173 but their function is unknown.	1.81567e-08
NZ_LS483441.1|WP_042016265.1|1399065_1400361_+|PAS-domain-S-box-protein	gnl|CDD|206779	cd11386, MCP_signal, Methyl-accepting chemotaxis protein (MCP), signaling domain. Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.	1.10322e-38
NZ_LS483441.1|WP_042016263.1|1401147_1402521_+|HD-domain-containing-protein	gnl|CDD|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	5.66689e-64
NZ_LS483441.1|WP_042016264.1|1400505_1401063_+|DUF3332-domain-containing-protein	gnl|CDD|371739	pfam11810, DUF3332, Domain of unknown function (DUF3332). This family of proteins are functionally uncharacterized. This family is only found in bacteria.	3.13558e-44
NZ_LS483441.1|WP_042014264.1|1420078_1421449_-|adenylosuccinate-lyase	gnl|CDD|236452	PRK09285, PRK09285, adenylosuccinate lyase; Provisional.	0
NZ_LS483441.1|WP_042016257.1|1409883_1410624_+|prolyl-oligopeptidase-family-serine-peptidase	gnl|CDD|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	1.2878e-31

Protein sequences

>NZ_LS483441.1|WP_042016259.1|1405333_1407043_+|NAD-dependent-malic-enzyme
MATGQYLLWKDAQGHDFRPVALTGTNLLNDRNLNKGTAFTEQERADFELGGLLPPQVQTFEAQLERVYEAFLSACSDIEKYQNLRALQDRNETLFYALLSRHVEEMTPYIYTPTVGKACQEFSHRFQKPRGLYITPKNVEDMGSLARHMDAKAVRIIVVTDSQGILGIGDQGVGGMGIPIGKLALYTLGAGIHPACCLPIALDVGTDNQALLDDPMYLGQPHRRIRGKEYDDFIDKFVAGVKRHFPNAVLQWEDFSKSNAFNNLARYQQALPSFNDDIQGTGAVVLAGIIGAVKSKGETLGQQHYLVYGAGAGGVGVADQICAGMIREGLDPQAARDRIYILDTQGLVCDNREGLDEYKRRYAKPGLLLAQWDLQGKAGLTEVLRHVPITVLLGTSGAGGAFQEEHIQLMLTHCERPMVFPLSNPTANCEALPEDIFRWSQGRAIVATGSPFKDVHHEGQDYRIGQGNNVFIFPGVGLAAIVSQIREISPDIFTTAAFALAECVSEADLARGTVYPRISELRNISVHVATAVLKDIVRRDPSHPLIGQDLQEHILSHMWEPVYLPYRRV
>NZ_LS483441.1|WP_042016260.1|1404497_1405112_-|molybdenum-cofactor-guanylyltransferase
MTLSSSPAFLVSGVILAGGRATRMGGDDKGWVPLAGTPLIQHVLTRLRPQVDEVLINANRSQARYRQLAPVIGDAQADFQGPLAGMLAGLTAARHDWVLFVPCDGPALPLDLMTRFRAAITPDTDLVVAHDGEHLQPVVALLRRALRPSLSQALADGERKTGAWFARHRMAVVPFADLPDAFVNLNSPAELAAWEARLREGGTP
>NZ_LS483441.1|WP_042016261.1|1403751_1404501_-|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B
MSPLPLLGFVAWSGTGKTTLLERLIPRLVARGLRLGVLKHTHHAFDMDQPGKDSHRLRQAGATQVMAASDRRHALIRETPEGEPPFEALLARFDTNALDLLLVEGFKHRRFPKVELYRAAIGRPLLFPDDPDIVALVSDAPQATTLPRFPFEDLEAIADFICARLPPHEPRQAPPPLRLCARLLAALPPSAKQGVVPGLLSQDEAGTLLVRPVDGGHDSANCHIERAPGSAALPPGERVMVRLPTGAPP
>NZ_LS483441.1|WP_042016262.1|1402590_1403670_-|FUSC-family-protein
MHLNAPLSRFDLLIYGRYRLVHGLRIALAFTLTFLLTRELKLPESTWPLITLVVVMGPISFWGNVLSRALQRVVGTVFGAACGVVALYLELYSLPLMLAWCCAIMFLCGYLALGKRPYVGLLIGITLGVIVGGVPGDIETALWRSGDVILGSVLALLFCSIYPQRAYTHWRLQMHDTLQQAGRLYHTHLSPNVLERPRLTRSHARLLAKIVSLRPLLAPAVKETRLGSPLFEATQTTLRNSVCTLEMLANTYWRDRQSHFLMQSHPGLRACQQATESVLTELALMLKSGDTTAADQAIGRLQAAAARLDGDAIQAPGQGHDPTLGGYLWLNLHLIEQLAHLHRLLGLVLQPYAKPSARP
>NZ_LS483441.1|WP_042016263.1|1401147_1402521_+|HD-domain-containing-protein
MTVNGLRLAELIGSLSHALDMTEGQPRGHCIRCCWIGSRLGEQLGLDARQRHDLYYTLLLKDLGCSSNAARICELYLTDDLHFKRDFKLVDGSFSEVVNFVLGHTGLQADLLGRFRSLFHIFRNGDQIANELILTRCHRGADIARQLRFSDEVAQGILSLDEHWSGKGRPQQLAGEAIPLFSRIALLCQVVDVFHAAAGPDAAMRELRERSGNWFDPALVSAFEALADEAFWQGLADPALAERVFAHPAGQGEVALDEDYLDEIAAAFGQVVDSKSPYTAGHSGRVALYTDILAAQMGLSEPRRRWLKRGALLHDVGKLGVSNAILDKPGKLDEQEWAAVQMHAAYTEEILGRIGAFEELALVAGAHHERLDGKGYPKGLKGEAITLETRIITTADIFDAITAKRPYRDAIPVPRALEMMAENLGTAIDPDCFAALKAGIEDFSLYLTPEQPLARAS
>NZ_LS483441.1|WP_042016264.1|1400505_1401063_+|DUF3332-domain-containing-protein
MAVRQRGRALALLLGMGASLGLGGCMGQMGLSSMVTKGNLSVVDNRYGRAGVFVLLSPVYGLAATADLFVFNTIEFWSGKNPITGKAPALVDQKSDAIIKVNQHLDPALNQVPLALLPQGVREVQVSYPDERTAQMEIHYIDGQRSLMRGEMRGERLDLYLDDKLVSTLSREQRDAAASRGAGQV
>NZ_LS483441.1|WP_042016265.1|1399065_1400361_+|PAS-domain-S-box-protein
MFNHKLKAQLQACQTRLDEEQGITEAIKAGAATVIFSPEGIIQEVSTPFLALMGYGAAELIGQPHSQLCPRAWGESGDYRQFWRRLAQGEVQSGTFERVNRQGETRWLEATYFPVKHQGRVTRVLKMASDVTEQHQRLGRLEALTEALDRSRAMIEFTPNGDILHANANFLSVMGYTLGEIAGRHHRIFCDETFLREQPRFWEELARGQFKSGLFMRHNSRGQAVWLEATYNPIRDGSGKVVRVVKFASDITARIEQNHATREAARLAHSTAQETLHSAEEGAGLLRAVVQTSSLIASQVDKAIALIGQLNEQSRSIEAIVSTISAIADQTNLLALNAAIEAARAGEQGRGFAVVADEVRQLAARTSLSTDEIARVVQKNRELTARVTDDMAGVAGSAELGKQQIAGVDKLMSEIHQEADRVSQTVSALSI
>NZ_LS483441.1|WP_042016266.1|1398398_1398863_+|GNAT-family-N-acetyltransferase
MKVREALAADIPALTTLRMALFCEVGELARPDEDPVLREATQAYFMQAQEEGSARSWVVEEEGEVVACATLALFVRPPYPGNLAGREGYLLNIYTQPAWRRRGMANALLVAMVAYAREQQLGKLWLHASSDGRAIYERFGFAGNPACLECVPGR
>NZ_LS483441.1|WP_042016267.1|1397882_1398278_+|DoxX-family-protein
MTTQTLARPLGPLVERILPWCSGGLLLLARLWVATIFLRSGWLKFTAWDSTLYLFEFEYQVPLLPWQWAAYAGTATELLLPLFLLAGLFTRLVALLLFGFNAMAVISYPALWAGGFHDHQLWGWMLLTLAV
>NZ_LS483441.1|WP_042015799.1|1395874_1396249_+|hypothetical-protein
MKRILMVLSLCVAVMGMGVAQSATSGAQQECEAQAAVKKLAGAAKTSFVGKCVKDASASAKASQCEKAAADKKLAGAAKNSFVQKCLKTDAAADKATRCEKAAADKKLAGAAKNSFIQKCVKTA
>NZ_LS483441.1|WP_041213272.1|1408500_1409739_+|uracil-xanthine-permease
MFSLVKQSVAGLQILFVAFGAMVLVPLLTGLNPSMALLGAGVGTLLFQLCTRRQVPIFLGSSFAFIAPIIYATQTWGLPSTMFGLFAAGFMYFILAAIIRARGMGFVHKLLPPVVIGPVIMVIGLSVAQVACNMAMGRAGGEQVVPATTALTLAGISLAVTLIAAVFCKGWIKLIPILCGVIAGYVSAVLMGQVSFDGMVNAPWLALPHFETPEINWAAALFMLPVAIAPCIEHIGGVLAIGGVTGKDYTKDPGLHRTLAGDGIGVCFAGFIGGPPVTTYAEVTGAVMITRNFNPVTMTWAAVFAIILAFFGKFNALLTSIPMPVMGGIMLLLFGSIAAIGLKTLVESKVDLGLSRNIAIVAVTLTVGVGALEMKIGDFALAGVGLASVAAILLNLILPQHSETGAMESAKD
>NZ_LS483441.1|WP_042016257.1|1409883_1410624_+|prolyl-oligopeptidase-family-serine-peptidase
MKRAWILALLGLMGSGAAEAGAVRYEVEGKPFEGYYLAGTDKQAPLVVLVHDWDGLNGYEIKRAEMLVALGYSVFAVDLFGAGVRPSTVEDKKRLTGALYQDRPRMRTLLQGGLAEAGRQGGRLDNAVALGYCFGGAAVLELARSGADLKGVVSVHGGLETPAGQDYKEVKGELLVQHGSADEAVSLGQFAALVAELESAGVKHEATSYSGAPHAFSVFGSDNYRADADAKSWQRFTGFLKEVTGS
>NZ_LS483441.1|WP_039039924.1|1410736_1411699_+|IS1595-family-transposase
MDTQAFQHLLSLFPQLTMRQRRLAQHELTTPHPITSLAAQLPACRCCPHCQAEATQLAPWGWSRGLRRYRCKQCLRTSSVLTKTPLARLRKAQCWEDYAQALIDGLTVRQAAVRCGVCKNTAFLWRHRFLKAMASHQAAREGGIVEVDETFFLESFKGQRGLPRPARHRGGKGRTRGTGPDYIPVMVVQDRAGHHADFQLEKMNAETVIAVLTPLVSSDAVLCSDGAGVYASFSKAQGVTHQVVRNRQGERVVGAYHIQHVNGYHRRLKEWMERFHGVATHYLRNYLGWRRMLERYGREVNVPRCLHEALGRPMQHVIGT
>NZ_LS483441.1|WP_042015825.1|1411727_1412726_-|beta-propeller-fold-lactonase-family-protein
MQQVVYVANPVSGLIHVFRLEAGTLAPLQEVQTGGEVQPLAISPDRRWLHAGVRPDFRVLSFPIAADGRLGAPTSAPLLGSASHTCTDGSGRLFFAASYAFNHVTVSRQDQAGRMQPPHQRLDHLMAAHSVTWLPGQNGEQELLVACLKEDRVRRFALVDERLVPHPLGDIHTAPGAGPRHLAQHPDNGDLYCLNELDATLNRYHREADGQIVARESLDMLPPGYEGDRWGADLHLTPDGRFLYTSERASSLLTLFGVSPQDGALTPLGHFPTEACPRGFAIDHSGHWLIATGQQSHEVALHAIDPESGQLTPGPRSEVGKGAMWVRVLALP
>NZ_LS483441.1|WP_042015823.1|1412783_1413392_-|LysE-family-translocator
MDSLYAVVLFAISASVTPGPNNIMVMSAGASVGIRKSLPLLMGICVGFTLMLLLVGLGFGQLFTRVPELHMFIKCAGTLYLLYLAWLIARPTDGMADSNGARPFGFFKGALFQWVNAKAWVVATGAIAAFTSTGSDPFEQHLVIALTFFIVSFPCVGLWLLCGSLLKRWLANDLARRRFNQVMAALLVLSVVPVIREILIPA
>NZ_LS483441.1|WP_042015820.1|1413512_1416830_-|mechanosensitive-channel-MscK
MLSTRFKRASATLLPLLCLLITFWTPSTLAQDLPQRATVQRALDALGKSDTPTASQQADQKFLTDTLSLLDSIDKEKSKAKTQSERLRTLPAELKEIGAKLDALTQGKSPEQLKSEYATMSLAELDARQPEIMANMQAAQEALGTIGSQITNLQTLPERAQASMSRAYQRSQEIRTRLNAGDGVSSAEKMKLGAELALLDLQLANLQKELDNRTSMQDLVVKQRDYQSARLASEEQKLQALQEQSSAKRLGDTEKTAEETGELVAAEDNPLVQKEQELNYQLSQQLISSTNSLNTLAQKNLQAKSMLERGTQTERNLNEQVQMLKGNLLLSRILYQLYQQLEAAPSTLVKNLEEQIADLHLAQFELSQQRDQLFQKNQYLDNLIASSGETVSDEDRASLAKLIDTRIGLLDQLNRQMDAQLTNAISLQLTQQQLTRVYASIEFTLQQHIFWVSSNKPIDAKWFITWPAQAFKQASDWVLKPDWSGWGDMLLAVSLLALPLLLVGGLLLWKRGTLLERQKKIVKDLGRFRQDSQWHTPRALLFTVLQRLPGTLFILAAGLLLAYCGLLSPKLIFQITLNLALGYLVFSVYLSVMRPGGIGETHFRMPRDELQAKRNSMRYLWLPLLPLIMLSTKAVVEPSSLGNDVIGQGMTMLLLGLTAYLVLPISRARIKGEASMLQTLTAVSLALAPVALMVLAALGYYYTALKLTGRLIESFYLIIIWGLVYRTALRGLELAARRLAYRRAVAKREHKTQEDAEGGEAIEEQPMDLEEVSQQSLRLTRIMLLLVFGVAFYWLWSDLVAVFTYLDSVVLWHKSEGTGANAVLYPISLSDVLTGLFVFGAALSLARNLPGLLEVLVLSKLRLAQGTAYAFTTMLNYALIGVGSLTALAMLGVQWEKLQWLAAGLSVGIGFGMQQIVSNFISGIIILFERPVRIGDTVTIGTISGTVNKIRIRSTTLTDFDRKEVIIPNQQLMIERLINWSLSDTVTRVIARVGVAYGSDLDLTRKLLMQAAMENSRVLKDPAPIVYFLTFGPSTLDHELRFFVSELGDRNPAIDELNRRIDVLFREHGIEIAFNQMDVYIKNMQGDEQKVESRPALPPAGNQPV
>NZ_LS483441.1|WP_010673615.1|1416979_1418392_-|pyruvate-kinase-PykF
MKKTKIVCTIGPKTESKEMLGKMLDAGMNVMRLNFSHGDYAEHGGRISNLRAVMAETGKHAAILLDTKGPEIRTIKLEGGNDVSLVAGQTFTFTTDQTVVGNKDKVAVTYAGFASDLRVGNRILVDDGLIGLDVIEITEREVICKVLNNGDLGENKGINLPGVSIKLPALAEKDKRDLIFGCEQGVDFVAASFIRKKEDVLEIREHLKAHGGENIQIISKIENQEGLDNFDEILAVSDGIMVARGDMGVEIPVEEVIFAQKMIIEKCNKARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKYPLEAVTIMATICERTDAVMPSNLSAANDSNKLRITEAVCKGAVETSEKLDAPLIVVATEGGKSAKAIRKYFPKAWILAITTNKKTAAQLVLTKGVVAHVVDSIASTDDFYRIGKEAALEIGMGVKGDVVVMVSGALVPSGTTNTASVHVL
>NZ_LS483441.1|WP_041214786.1|1418795_1419926_-|cupin-domain-containing-protein
MYQLNLDIAHFLEHYWQKRPLLIKGGFIDFQDPISPDELAGLAMEEVIESRLVTRFNNKWEAAHGPFESYDHLGEENWTVLVQACNHWVPEVHELAVPFQFIPGWRFDDVMVSFSTPHGGVGPHIDNYDVFITQGQGKRHWRVGDAKPLNEFAAHAALLHCEPFEAIIDVIMEPGDILYIPPGFPHEGYAIEPSLNFSVGFRAPDAKALVSSFADHLIDNEIRTERYGDPDLQPRTRHGEIQPHELHRLRELMQQALDDETLFKEWFGTMISEAKHDLDVNPVEPDYSADEVADLLSQGEPAIKVPGLRSVWFSGESRTCYIDGEAWTLPSEDPAAIALLCDKDIITQDALVELADQAGFLQLLTRLVNRGYWFFG
>NZ_LS483441.1|WP_042014264.1|1420078_1421449_-|adenylosuccinate-lyase
MELSALTAVSPIDGRYGDKADALRPIFSEFGLLRFRVEVEVRWLQKLASHAGIPEVPALSEAANAVLDGIVSNFNEQDAARIKQIERTTNHDVKAVEYFLKEKVEVNPELAAVSEFIHFACTSEDINNNSHGLMLKTAREEVIKPYCEKLIGEIKRLAVEYRDMPLLSRTHGQPATPSTMGKEMANVAYRLERQLKQIMAVELLGKINGAVGNYNAHISAYPDVDWHQFSEEFVTSLGLTWNPYTTQIEPHDYIAELFDALARFNTILIDFDRDVWGYISLGHFKQRTIAGEIGSSTMPHKVNPIDFENSEGNLGLANAVFQHLASKLPISRWQRDLTDSTVLRNLGVAVGYSLIAYQATLKGISKLEANADAMAADLDANWEVLAEPIQTVMRRYGIEKPYEKLKELTRGRRVDAEGMRTFIDTLALPEAVKVELKKLTPANYIGDAQRLVDLLK
>NZ_LS483441.1|WP_010673618.1|1421479_1422091_-|high-frequency-lysogenization-protein-HflD
MSDKFQDRTMAFAGICQAAYLVQKVARDGSCDEASLRESLQSILVTNPTQPLEVFGSHLAIRDGYRALVEQLGADGSQKNAELTRYVVSLIALERKLAKRKDILNMLGERISQIGRQQQHFDLLDEQILANMASIYSDLISPIGPRIQVAGTPLFLQQPLVQHKVRALLLAGIRAVVLWRQLGGSRTQIIFARKKMVELAKRF

Crispr_ID: NZ_LS483441_4

• CRISPR_ID: NZ_LS483441_4
• CRISPR_location: 1516701-1516817
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_LS483441_4

Consensus_repeat	Method
GTTGTCGAGCAGGAAGATGTTAGTCATGG	CRISPRCasFinder

spacers of NZ_LS483441_4

>4.1|1516730|59|NZ_LS483441|CRISPRCasFinder
GACTGCTCCTTCGAAGTGCGGAACTGGTCGGTCAAAGCGTTGTAAGTGAACGAATCGAC

CRISPR arrays and Neighbor proteins around NZ_LS483441_4

CRISPR arrays

The CRISPR arrays of NZ_LS483441_4

>merge|NZ_LS483441|4|1516701-1516817|CRISPRCasFinder
GTTGTCGAGCAGGAAGATGTTAGTCATGGGACTGCTCCTTCGAAGTGCGGAACTGGTCGGTCAAAGCGTTGTAAGTGAACGAATCGACGTTGTCGAACAGGAAGATGTTAGTCATGG

>NZ_LS483441|4|3|1516701-1516817|CRISPRCasFinder
GTTGTCGAGCAGGAAGATGTTAGTCATGG	GACTGCTCCTTCGAAGTGCGGAACTGGTCGGTCAAAGCGTTGTAAGTGAACGAATCGAC
GTTGTCGAACAGGAAGATGTTAGTCATGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LS483441.1|WP_039039190.1|1522095_1523019_+|23S-rRNA-pseudouridine(2605)-synthase-RluB	unknown	unknown	gnl|CDD|182659
NZ_LS483441.1|WP_010673710.1|1526985_1528167_+|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl|CDD|184990
NZ_LS483441.1|WP_042014205.1|1506314_1506749_+|hypothetical-protein	unknown	unknown	gnl|CDD|377396
NZ_LS483441.1|WP_010673692.1|1507016_1507259_-|DUF3297-family-protein	unknown	unknown	gnl|CDD|371696
NZ_LS483441.1|WP_042014201.1|1513598_1515104_-|bifunctional-indole-3-glycerol-phosphate-synthase-TrpC/phosphoribosylanthranilate-isomerase-TrpF	unknown	unknown	gnl|CDD|236509
NZ_LS483441.1|WP_042014268.1|1505881_1506304_+|membrane-protein	unknown	unknown	gnl|CDD|377396
NZ_LS483441.1|WP_080767817.1|1508043_1510767_-|DEAD/DEAH-box-helicase	unknown	unknown	gnl|CDD|235032
NZ_LS483441.1|WP_042014198.1|1524197_1525373_-|dicarboxylate/amino-acid:cation-symporter	unknown	unknown	gnl|CDD|366058
NZ_LS483441.1|WP_042014266.1|1525541_1526024_-|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|379312
NZ_LS483441.1|WP_010673697.1|1515103_1516117_-|anthranilate-phosphoribosyltransferase	unknown	unknown	gnl|CDD|234682
NZ_LS483441.1|WP_010673702.1|1519874_1520495_+|threonylcarbamoyl-AMP-synthase	unknown	unknown	gnl|CDD|183245
NZ_LS483441.1|WP_039039188.1|1523270_1524134_+|acyl-CoA-thioesterase-II	unknown	unknown	gnl|CDD|182519
NZ_LS483441.1|WP_042014199.1|1521410_1522103_+|SMC-Scp-complex-subunit-ScpB	unknown	unknown	gnl|CDD|377219
NZ_LS483441.1|WP_010673703.1|1520487_1521369_+|segregation/condensation-protein-A	unknown	unknown	gnl|CDD|224273
NZ_LS483441.1|WP_042014204.1|1507400_1507934_+|metal-dependent-hydrolase	unknown	unknown	gnl|CDD|377294
NZ_LS483441.1|WP_010673689.1|1504821_1505715_-|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|176114
NZ_LS483441.1|WP_041214833.1|1512216_1513410_-|tryptophan-synthase-subunit-beta	unknown	unknown	gnl|CDD|235288
NZ_LS483441.1|WP_039039192.1|1518866_1519748_+|PHP-domain-containing-protein	unknown	unknown	gnl|CDD|223686
NZ_LS483441.1|WP_042014202.1|1511413_1512220_-|tryptophan-synthase-subunit-alpha	unknown	unknown	gnl|CDD|237285
NZ_LS483441.1|WP_041213205.1|1526195_1526831_-|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|182632

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_LS483441.1|WP_039039190.1|1522095_1523019_+|23S-rRNA-pseudouridine(2605)-synthase-RluB	gnl|CDD|182659	PRK10700, PRK10700, 23S rRNA pseudouridine(2605) synthase RluB.	1.01907e-157
NZ_LS483441.1|WP_010673710.1|1526985_1528167_+|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl|CDD|184990	PRK15030, PRK15030, multidrug efflux RND transporter periplasmic adaptor subunit AcrA.	3.79285e-126
NZ_LS483441.1|WP_042014205.1|1506314_1506749_+|hypothetical-protein	gnl|CDD|377396	pfam04657, DMT_YdcZ, Putative inner membrane exporter, YdcZ. DMT_YdcZ is a family of putative inner membrane exporters from both Gram-positive and Gram-negative bacteria.	8.6044e-14
NZ_LS483441.1|WP_010673692.1|1507016_1507259_-|DUF3297-family-protein	gnl|CDD|371696	pfam11730, DUF3297, Protein of unknown function (DUF3297). This family is expressed in Proteobacteria and Actinobacteria. The function is not known.	1.40435e-45
NZ_LS483441.1|WP_042014201.1|1513598_1515104_-|bifunctional-indole-3-glycerol-phosphate-synthase-TrpC/phosphoribosylanthranilate-isomerase-TrpF	gnl|CDD|236509	PRK09427, PRK09427, bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF.	0
NZ_LS483441.1|WP_042014268.1|1505881_1506304_+|membrane-protein	gnl|CDD|377396	pfam04657, DMT_YdcZ, Putative inner membrane exporter, YdcZ. DMT_YdcZ is a family of putative inner membrane exporters from both Gram-positive and Gram-negative bacteria.	1.94995e-20
NZ_LS483441.1|WP_080767817.1|1508043_1510767_-|DEAD/DEAH-box-helicase	gnl|CDD|235032	PRK02362, PRK02362, ATP-dependent DNA helicase.	4.40147e-79
NZ_LS483441.1|WP_042014198.1|1524197_1525373_-|dicarboxylate/amino-acid:cation-symporter	gnl|CDD|366058	pfam00375, SDF, Sodium:dicarboxylate symporter family.	2.53614e-74
NZ_LS483441.1|WP_042014266.1|1525541_1526024_-|methyltransferase-domain-containing-protein	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	6.50857e-10
NZ_LS483441.1|WP_010673697.1|1515103_1516117_-|anthranilate-phosphoribosyltransferase	gnl|CDD|234682	PRK00188, trpD, anthranilate phosphoribosyltransferase; Provisional.	3.3487e-176
NZ_LS483441.1|WP_010673702.1|1519874_1520495_+|threonylcarbamoyl-AMP-synthase	gnl|CDD|183245	PRK11630, PRK11630, threonylcarbamoyl-AMP synthase.	6.47351e-127
NZ_LS483441.1|WP_039039188.1|1523270_1524134_+|acyl-CoA-thioesterase-II	gnl|CDD|182519	PRK10526, PRK10526, acyl-CoA thioesterase II; Provisional.	1.05024e-173
NZ_LS483441.1|WP_042014199.1|1521410_1522103_+|SMC-Scp-complex-subunit-ScpB	gnl|CDD|377219	pfam04079, SMC_ScpB, Segregation and condensation complex subunit ScpB. This is a family of prokaryotic proteins that form one of the subunits, ScpB, of the segregation and condensation complex, condensin, that plays a key role in the maintenance of the chromosome. In prokaryotes the complex consists of three proteins, SMC, ScpA (kleisin) and ScpB. ScpB dimerizes and binds to ScpA. As originally predicted, ScpB is structurally a winged-helix at both its N- and C-terminal halves. IN Bacillus subtilis,one Smc dimer is bridged by a single ScpAB to generate asymmetric tripartite rings analogous to eukaryotic SMC complex ring-shaped assemblies.	1.411e-61
NZ_LS483441.1|WP_010673703.1|1520487_1521369_+|segregation/condensation-protein-A	gnl|CDD|224273	COG1354, scpA, Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair].	3.34914e-60
NZ_LS483441.1|WP_042014204.1|1507400_1507934_+|metal-dependent-hydrolase	gnl|CDD|377294	pfam04307, YdjM, LexA-binding, inner membrane-associated putative hydrolase. YdjM is a family of putative LexA-binding proteins. Members are predicted to be membrane-bound metal-dependent hydrolases that may be acting as phospholipases. It is a member of the SOS network, that rescues cells from UV and other DNA-damage. Expression of YdjM is regulated by LexA.	2.69427e-23
NZ_LS483441.1|WP_010673689.1|1504821_1505715_-|LysR-family-transcriptional-regulator	gnl|CDD|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.23984e-95
NZ_LS483441.1|WP_041214833.1|1512216_1513410_-|tryptophan-synthase-subunit-beta	gnl|CDD|235288	PRK04346, PRK04346, tryptophan synthase subunit beta; Validated.	0
NZ_LS483441.1|WP_039039192.1|1518866_1519748_+|PHP-domain-containing-protein	gnl|CDD|223686	COG0613, COG0613, Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only].	1.78869e-84
NZ_LS483441.1|WP_042014202.1|1511413_1512220_-|tryptophan-synthase-subunit-alpha	gnl|CDD|237285	PRK13111, trpA, tryptophan synthase subunit alpha; Provisional.	6.48162e-124
NZ_LS483441.1|WP_041213205.1|1526195_1526831_-|TetR-family-transcriptional-regulator	gnl|CDD|182632	PRK10668, PRK10668, DNA-binding transcriptional repressor AcrR; Provisional.	6.27394e-49

Protein sequences

>NZ_LS483441.1|WP_010673697.1|1515103_1516117_-|anthranilate-phosphoribosyltransferase
MHQHLNTLYQGQSLTRDAARDAFGQVVRGEVDPIVLASLLTALKIKGETPEEIAGAAEALLAEARDFPRPDYAFCDIVGTGGDGLNTINVSTTSALVAAACGLKVAKHGNRSVSSKSGSSDLLDKMGIKLDMSPAQARRCLDELGVCFLFAPQYHAGVRHAMPVRQALKTRTLFNVLGPLINPARPSFQLMGVYAPELVRPIAETLLALGLKTGMVVHGAGLDEIAIHGPTQVAEIRDGEIREYLLTPADFGLDTYPVSAIQGGEPEENRAITAAILEGRGSPAHNAAIAANVAPLLVMAGEAPDFRQAAARVLAVLASGQAALLARDLATLSHQEA
>NZ_LS483441.1|WP_042014201.1|1513598_1515104_-|bifunctional-indole-3-glycerol-phosphate-synthase-TrpC/phosphoribosylanthranilate-isomerase-TrpF
MSATTTACPRGTHPERPTGNSQLRKDNEMSDVIAPHAFLNMASISQTILGKIVAAKQEWVAARKESQPLASFQDALTPSDRDFEGDLRQGSTRFILECKKASPSKGLIRNDFSPEAIADIYGHYATAISVLTDEKFFQGDFAFLPRVRGRVQQPVLCKDFMIDPYQVYLARHYQADAILLMLSVLTDEGYRALFNVAKELGLGVLTEVSNEEELTRAIDLGAPVIGINNRDLRDLSVDLARTRQLAARIPGDRVVISESGINHRAQVAALRHHAKGFLVGSSLMAEPDLEAAVRKLVLGQNKVCGLTRPEDATAAHQAGAVFGGLIFVAKSPRYVDIPAARAVMAGAPLSYVGVFRNAQPATIAKTVDALGLAAVQLHGDEDAAYIETLRPLLPAGCQIWKAVGVTSGEPLPALDYPADRLLLDTKVGSQSGGTGQAFDWTLLAGLDKSKLMLAGGLNPDNALEAAQVGCVGLDFNSGVESAPGRKDAHKLTAAFGALRQL
>NZ_LS483441.1|WP_041214833.1|1512216_1513410_-|tryptophan-synthase-subunit-beta
MTLLNPFFGEFGGMYVPQILIPALLQLEKAFVDAKDDPAFVAEFQALLTEYAGRPTPLTLTRNLTKGTKTRLYLKREDLLHGGAHKTNQVLGQALLAKRMGKHEIIAETGAGQHGVATALACALLGLKCRVYMGAKDCERQKPNVFRMKLMGATVIPVHSGSSTLKDACNEALRDWAANYETAHYLLGTAAGPHPFPTIVREFQKMIGEEAKAQCFEKEERLPDAVIACVGGGSNAIGMFADFIDEPSVRLIGVEPGGHGIESGEHGAPLGHGSKGVFFGMHSFLMQDNQGQIQESYSVSAGLDFPSVGPQHAHLAAIGRAEYPSVTDKEALDAFQELAKSEGIIPALESSHALAHALKMARSEPEKEQVLIVNLSGRGDKDIFTVADIFEKEGTLS
>NZ_LS483441.1|WP_042014202.1|1511413_1512220_-|tryptophan-synthase-subunit-alpha
MNRYAQLFSRLDKANQGAFVPFVMLGDPTPELSLAIVDALVEGGADALELGIPFSDPVADGPTIQGAALRAFASHTTPDDCFGLLARIRAKYPQLPIGLLVYANLVYVRHIDGFYEKCQQAGVDSVLVADVPVQMCEPYKAAADKFGIDSIFIAPPNGDAETLKAVAELGSGYTYLVSRAGVTGAETKAGMPVEGLINSLREFNAPPALLGFGISEPAQVREAIKAGAAGAISGSAVVKIIETHHQNPEHMLTRLKEFVEGMKAATNR
>NZ_LS483441.1|WP_080767817.1|1508043_1510767_-|DEAD/DEAH-box-helicase
MSVHSITSNGFNDFIKETLTSWHIKALTDIQKRAVESGVLLGESLIVSAPTSSGKTLVGELAALAGIQNGKRIIYLVSHKALADQKYLDFCQRFGDNAPRPLTSIGLSTGDREEGYVDAQFIVATYEKALGLLLAGQLRPREAVIIADELQILREEGRGPEIETLCSALRQRGIGQFIALTATVENAEDLAGWMKCKLVSSNHRDIPLHQEIWFNGQSYRTTFGQEQGQLVDIGGNAPSNVEDVVSKLLELERGPVLVFTESRREATQLAESFSRRRPKQSRGIALSNQLELFSEPTESSNSLREHAERHVTFHTADLSPQERQVIECGIREGDIDVCFATTTLAAGVNFPFRSIVFWKLTYQWGDRAGSRIARWDYRNMSGRAGRLGMHSEGFSIIIPRNPVELEHANQLVLPQNDQLESRYFSVGLRKTVLAIISAGLASNHESVMGFFKNTLYWYQTLETNPVKLQALEARTHESIEWLLSYNLIITEGNELSVTPFGAVTASTGLLPSTAVQFAQLLTSNSETLENRFEEIIPGVIHAVVMSDEFSGERPTRYLTFQPVEYESVSFLRGQNLLMPLNSINVQSAQCSHAVFLFSQGEQERKIAFRTKVSSGQIHRLSNDIAWVLDGLQKLSCVPQFNCSQNVANNLGMLSRMVRWGAPAEALDVLRVAQKYQVPGVGRQRAMALVSQGITTLKDVLMSSIDKLASILRNPMRAEALVEAVESVSGVSEDRLTNAHTRIAQTAGIDNLINNCNIKFDTEYETAIIELLREEVSWIVTEVDDGKRQNVPDLMLELGDKTILIECKTTHKKNPLIGKEEAWAILQKAADFDPNYKRVTLGKPHFDETCKKKVAGAHDITLIEHTVFIEAFLRVVLGSISAEDFVEWLGQPGLSDLNRLGGKPTYQE
>NZ_LS483441.1|WP_042014204.1|1507400_1507934_+|metal-dependent-hydrolase
MPTIVTHAAVPLCLGLGLGCRIIPPRLLLAGIAIAMLPDADVLAFKLGVAYGHVFGHRGFTHSLLFAFALPTLAMLFHRQFRASAATVWSFLLVSLLSHSLLDSLTTGGKGVGWLWPWRDERFFAPWQVIRVAPFKLEAYLTARGEAVILSELYWVWLPVVVLMLVLMGWRVWGRGR
>NZ_LS483441.1|WP_010673692.1|1507016_1507259_-|DUF3297-family-protein
MSDNKPALPDRLAANPRSPHHVAECFEHEIGIRVNGKERTNVEEYCISEGWVKIPSPKAKDRYGNPMLITVKGTVEAFYA
>NZ_LS483441.1|WP_042014205.1|1506314_1506749_+|hypothetical-protein
MTLLILLGLLNGVAVSLSRTLNGRLASARGAMTASLANHLLGFGLLGALLILKGAPWERLAGLDPWLLLGGVLGALFVAISSWAIGRVGALACALLIVTGQLAGGALLDALAGRLAASDLLGILLVLAGAALQRWQGGKSRSRG
>NZ_LS483441.1|WP_042014268.1|1505881_1506304_+|membrane-protein
MGALAAFAAGLLLALMIAQNGALSRATDPWLASWLAHGVGTLVAGLLWWLSPRPPTPEAAPPWAWLGGLPGALTVVLAALCLNSPLGMAGTLALLLLGQLLFGALCDGLGWLGLTRRRPSGKDALAALLVMAGALLIVLH
>NZ_LS483441.1|WP_010673689.1|1504821_1505715_-|LysR-family-transcriptional-regulator
MNQEAFALLPAFVAVVESGTFSGAARQLGLSKSVLSKKVSQLEQALGCQLLYRTTRSLTLTEAGERYFETVRHAVRLASDGEDAIGALQSAPRGLLRVTVPMVYGRRHIAPLVPEFLALHPEVQLQLEMSDARQDLVAEGFDVAVRIGELEDSSLVARRLAPCLSTLCAAPAYLAQAGTPRTPADLERHNCLFYSLFRGGTQWRLHGPEGEVAITPRGNFEVNNSDAIHTALLAGLGIGNMPDFIVARDLAIGRLVPVLPDHALPEHGIWCVYPKRRHLPAKVEAWLAFLQERLGLR
>NZ_LS483441.1|WP_039039192.1|1518866_1519748_+|PHP-domain-containing-protein
MRFDLHCHTTASDGVLSPADLVRRAAEKGVEVLAVTDHDTLDGLEEVRQTISADQLPLRLVSGVEISTGWEHHEIHIVALGVDEKNPQLLAFLAGQRARREARAEEIGRRLEKCLIPGTYEEAKQLAGDAAVTRAHFARVLVARGVADNMQKVFKKYLSRGNKGYVPAEWPGMGEAIEAIHAAGGLAVLAHPSRYNLTAKWIKRLLVAFKAVGGDAMEVSLPQQSPQERANLGQWAREHDLYISVGSDFHFPSNWTELGRHLWLPKEGMPLWLGHPGHFGLTPEEHAGLLASR
>NZ_LS483441.1|WP_010673702.1|1519874_1520495_+|threonylcarbamoyl-AMP-synthase
MSQHFYVHPDNPQVRLISQAVQILQNGGVIVYPTDSGYALGCQMGNKDALERICRIRRIEPNHDFTLVCRDLSEISTYAKVDNTAFRLVKNNTPGPYTFIFKATKEVPRRLMNEKKKTIGIRVPANNIALALLEALGEPLLSTTLILPGSEMAEFDPEEIADKLGKQLDLVVNGGYLGEQPTTVVDFSDDEPVLRRRGAGDPTPFE
>NZ_LS483441.1|WP_010673703.1|1520487_1521369_+|segregation/condensation-protein-A
MSDLADPVPALTTPAGTTGEASLPPPIATVLGQPYHELPQDLFIPPDALEVFLDTFEGPLDLLLYLIRRQQLDILNLPILQITAQYMEYVDLMQGLNLELAAEYLLMAAWLAEIKSRLLLPKAPELEDEEEGEDPRVTLIRRLQEYERYKLGAERVNALPRVEREIFVAAAMAPDFGALKPLAPDVSLVELALYMQSVVKRATHFEHHQIRREQIPTRVRMAEILAMLSLGQTLRLEQVLRAEEGRMGVLVTFLALLELCKEQLIWILQAEPLGPIHFALASQGKGEEHEHLH
>NZ_LS483441.1|WP_042014199.1|1521410_1522103_+|SMC-Scp-complex-subunit-ScpB
MALPAERLKTLIEAAIFVAGRPLTVSEIKGSVLSDYPVTGRYVQLLLAELRQDYSERGVELKEVASGWRFQARQEYAEELSRLWSERAPRYSRAVMETLTLIAYRQPITRAEIEAIRGVAVSSQIVNTLKERGWVRSIGHKEVAGRPELLATTREFLDYFNLQSLEQLPELDPELQAPLSLMPGEGGDGQPLAGRAEHEHGGEANGAFPQEPRLSAMSAGSDQQSGKPDE
>NZ_LS483441.1|WP_039039190.1|1522095_1523019_+|23S-rRNA-pseudouridine(2605)-synthase-RluB
MSEKLQKVLARAGQGSRREMEALITAGRVSVDGKVATLGDRVEVNAVIRVDGHQVKTRAAEEVICRVLAYHKPEGEMCTRHDPEGRPTVFDRLPKMDGARWIAVGRLDVNTSGLLLFTTDGELANRLMHPSHEVEREYAVRVFGEITEAMLQRLRKGVQLEDGMAKFNKIKPAGGEGLNQWFNVTLTEGRNREVRRLWESQEVQVSRLMRIRYGDVKLDRGIPRGGWQELKLPEVNYLRGLVNLPNETESKVDLQQDGKSTRHKQAAQIRRAVKRHKEMQGKEPRARATTARRKPTSSTRNSGTGSK
>NZ_LS483441.1|WP_039039188.1|1523270_1524134_+|acyl-CoA-thioesterase-II
MSKVLDELLALLALEKIEEGLFRGQSQDLGLRSVFGGQVMGQALSAAKQTVASDRQVHSFHSYFLRPGDANKPIVYDVENIRDGQTVSTRRVKAIQNGKPIFYLNASFQVEAEGFEHQAKMPAGITPPEQLKSELELVRPYEQMIPAALRDKILCEKPIEIRPVTLVDPIRPDVHEPLRYTWFKANGPVPDDQRVHNYLLAYASDFHFLFAALQPHGVSYWEPDMQVATIDHSMWFHREFRLDDWLLYVVDSPSASGGRGLVRGQFFTRDGVLVASTMQEGVIRRRG
>NZ_LS483441.1|WP_042014198.1|1524197_1525373_-|dicarboxylate/amino-acid:cation-symporter
MKLVLNLVAGILAGLLLGLYAPEWVARVLFTAKTVIGQLITFTIPLIILFFIMSGIASLPKNSGKLLGKTVGLSYCSTILAGLFAFTVASHLIPHLTTAAEPTAEAATKLASYINLEIPPLFGVMSALAAAFVFGIGISATQATDLRRVADQGRDIIDRLLARVIIPLLPFYIAGVFVEMTVEGTVFATLKTFGVVLVMAIVMHWIWLCVLFVGTGLAQGRSPVMLIKNMLPAYFTALGTMSSAATIPVALQASKRNGVSDGIANFTVPLCATIHLCGSTITLVTCATAVMFLSEHLAIPGYGTMVPFIMMLGVIMIAAPGAPGGGVMSALGLLTSMLGFGEASIALMIALYLAQDSFGTACNVTGDGVIALWADRFARGEPALSTEQDAA
>NZ_LS483441.1|WP_042014266.1|1525541_1526024_-|methyltransferase-domain-containing-protein
MLGSGRHLLEAGCGAGEDLRLFRQQGLTVTAFDASRAQAAAASRLCGQPVRVCRFEQMRSVVPYDGIWASGSLPCLPEHEIAPALGHLATLLKAGGPLYASFPHGMGEPQPRSGEYPLQTRLDEAGLRRLIAPLPFTLHHGWVGEDEVNGPWLHALLVRR
>NZ_LS483441.1|WP_041213205.1|1526195_1526831_-|TetR-family-transcriptional-regulator
MARRTKEEAQQTRCNIMSTALDLFCQQGLARTSLTDIAKATDLTRGAIYWHFKNKEELFVTLWEELCAPLSHQLDACVDEAEADPLGKLRSFLKEVMLKISTEPAHQQMFTIMFNLESMEGEAAVMREHMHLQSMNFFRDLEITLANAVRRGQLPEGLDLRRAATLLHCTLDGYIINWLHFPDRIDLIEESDFLLDTLFTLIASPTLRRHP
>NZ_LS483441.1|WP_010673710.1|1526985_1528167_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MHKHILARSVGLALLASGLLAGCGDKDGAQQAMGEMPPAAVDVVTLHTAPLQLLSELTGRTAPLRVAEVRPQVNGIILKRLFTEGSDVKAGQLLYQIDPAVYQAEVASAKANLAKAEANERSARLKAQRYAELVKVKAISSQEYDDADAAWKQQLAEIGAAKAALQTANINLAYTRITAPISGRIGKSAVTEGALVTAQQADSLTSISQLDPMYVDVRQSTADLLRLKRLVAEGKLTQGEKDGAGVSFQLEDGSQYGEKGALQFSDVTVDEATGMVTLRVIVPNPDQLLLPGMFMRATLQEGERPQGLLVPQTAVTRTPKGGATVMVVTADNKVELREVQVGRMSGDSWVVESGLKAGEKVIVAGLQKVKPGVVVAPTERAGNSAQQTPATKQ

Crispr_ID: NZ_LS483441_5

• CRISPR_ID: NZ_LS483441_5
• CRISPR_location: 1818911-1819024
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_LS483441_5

Consensus_repeat	Method
GATGTGGCTGTCTGTCAGCAGCCGGCGCA	CRISPRCasFinder

spacers of NZ_LS483441_5

>5.1|1818940|56|NZ_LS483441|CRISPRCasFinder
GCAGGCCGGAGAAATCCATCGGCATGCTAGGCACCACCCTTGAACGAGGTGAAATC

CRISPR arrays and Neighbor proteins around NZ_LS483441_5

CRISPR arrays

The CRISPR arrays of NZ_LS483441_5

>merge|NZ_LS483441|5|1818911-1819024|CRISPRCasFinder
GATGTGGCTGTCTGTCAGCAGCCGGCGCAGCAGGCCGGAGAAATCCATCGGCATGCTAGGCACCACCCTTGAACGAGGTGAAATCGATGTGGCTGTCTGTCAGCAGACGGCGCA

>NZ_LS483441|5|4|1818911-1819024|CRISPRCasFinder
GATGTGGCTGTCTGTCAGCAGCCGGCGCA	GCAGGCCGGAGAAATCCATCGGCATGCTAGGCACCACCCTTGAACGAGGTGAAATC
GATGTGGCTGTCTGTCAGCAGACGGCGCA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LS483441.1|WP_010675145.1|1805502_1806324_+|membrane-protein	unknown	unknown	gnl|CDD|270317
NZ_LS483441.1|WP_041214974.1|1808619_1809636_+|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl|CDD|237845
NZ_LS483441.1|WP_042016930.1|1812222_1813032_+|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl|CDD|234577
NZ_LS483441.1|WP_029314728.1|1815456_1816260_+|cell-division-protein-DedD	unknown	unknown	gnl|CDD|236940
NZ_LS483441.1|WP_042016923.1|1807350_1808472_+|4-phosphoerythronate-dehydrogenase	unknown	unknown	gnl|CDD|240635
NZ_LS483441.1|WP_010675139.1|1813151_1814015_+|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	unknown	unknown	gnl|CDD|235547
NZ_LS483441.1|WP_042016946.1|1828902_1830060_-|2-methylcitrate-synthase	unknown	unknown	gnl|CDD|183463
NZ_LS483441.1|WP_010675134.1|1819228_1819885_-|Bax-inhibitor-1/YccA-family-protein	unknown	unknown	gnl|CDD|198415
NZ_LS483441.1|WP_042016948.1|1831390_1832371_+|quinone-oxidoreductase	unknown	unknown	gnl|CDD|176189
NZ_LS483441.1|WP_042016940.1|1823371_1824418_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|225375
NZ_LS483441.1|WP_042017039.1|1826284_1828900_-|Fe/S-dependent-2-methylisocitrate-dehydratase-AcnD	unknown	unknown	gnl|CDD|131386
NZ_LS483441.1|WP_042016952.1|1832445_1833294_+|taurine-dioxygenase	unknown	unknown	gnl|CDD|181947
NZ_LS483441.1|WP_029314727.1|1816365_1816710_-|TusE/DsrC/DsvC-family-sulfur-relay-protein	unknown	unknown	gnl|CDD|213798
NZ_LS483441.1|WP_042017038.1|1820048_1821002_-|AraC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197666
NZ_LS483441.1|WP_039038790.1|1830124_1831009_-|methylisocitrate-lyase	unknown	unknown	gnl|CDD|183086
NZ_LS483441.1|WP_042016921.1|1806377_1807100_-|phosphatase-PAP2-family-protein	unknown	unknown	gnl|CDD|182658
NZ_LS483441.1|WP_042016943.1|1824919_1826119_-|2-methylaconitate-cis-trans-isomerase-PrpF	unknown	unknown	gnl|CDD|131387
NZ_LS483441.1|WP_042016927.1|1809929_1812056_+|pilus-assembly-protein-FimV	unknown	unknown	gnl|CDD|274615
NZ_LS483441.1|WP_042016933.1|1814017_1815277_+|bifunctional-tetrahydrofolate-synthase/dihydrofolate-synthase	unknown	unknown	gnl|CDD|182774
NZ_LS483441.1|WP_042016938.1|1821117_1823274_+|TonB-dependent-siderophore-receptor	unknown	unknown	gnl|CDD|227114

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_LS483441.1|WP_010675145.1|1805502_1806324_+|membrane-protein	gnl|CDD|270317	cd13599, PBP2_lipoprotein_Gna1946, The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 periplasmic binding protein fold. Gna1946 shares significant structural and sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.	1.06978e-133
NZ_LS483441.1|WP_041214974.1|1808619_1809636_+|aspartate-semialdehyde-dehydrogenase	gnl|CDD|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	0
NZ_LS483441.1|WP_042016930.1|1812222_1813032_+|tRNA-pseudouridine(38-40)-synthase-TruA	gnl|CDD|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	7.51637e-151
NZ_LS483441.1|WP_029314728.1|1815456_1816260_+|cell-division-protein-DedD	gnl|CDD|236940	PRK11633, PRK11633, cell division protein DedD; Provisional.	3.64236e-53
NZ_LS483441.1|WP_042016923.1|1807350_1808472_+|4-phosphoerythronate-dehydrogenase	gnl|CDD|240635	cd12158, ErythrP_dh, D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains. D-Erythronate-4-phosphate Dehydrogenase (E. coli gene PdxB), a D-specific 2-hydroxyacid dehydrogenase family member, catalyzes the NAD-dependent oxidation of erythronate-4-phosphate, which is followed by transamination to form 4-hydroxy-L-threonine-4-phosphate within the de novo biosynthesis pathway of vitamin B6. D-Erythronate-4-phosphate dehydrogenase has the common architecture shared with D-isomer specific 2-hydroxyacid dehydrogenases but contains an additional C-terminal dimerization domain in addition to an NAD-binding domain and the "lid" domain. The lid domain corresponds to the catalytic domain of phosphoglycerate dehydrogenase and other proteins of the D-isomer specific 2-hydroxyacid dehydrogenase family, which include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence.	0
NZ_LS483441.1|WP_010675139.1|1813151_1814015_+|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	gnl|CDD|235547	PRK05654, PRK05654, acetyl-CoA carboxylase carboxyltransferase subunit beta.	0
NZ_LS483441.1|WP_042016946.1|1828902_1830060_-|2-methylcitrate-synthase	gnl|CDD|183463	PRK12351, PRK12351, methylcitrate synthase; Provisional.	0
NZ_LS483441.1|WP_010675134.1|1819228_1819885_-|Bax-inhibitor-1/YccA-family-protein	gnl|CDD|198415	cd10433, YccA_like, YccA-like proteins. A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.	1.44931e-85
NZ_LS483441.1|WP_042016948.1|1831390_1832371_+|quinone-oxidoreductase	gnl|CDD|176189	cd05286, QOR2, Quinone oxidoreductase (QOR). Quinone oxidoreductase (QOR) and 2-haloacrylate reductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. 2-haloacrylate reductase, a member of this subgroup, catalyzes the NADPH-dependent reduction of a carbon-carbon double bond in organohalogen compounds. Although similar to QOR, Burkholderia 2-haloacrylate reductase does not act on the quinones 1,4-benzoquinone and 1,4-naphthoquinone. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	9.13777e-180
NZ_LS483441.1|WP_042016940.1|1823371_1824418_+|alpha/beta-hydrolase	gnl|CDD|225375	COG2819, COG2819, Predicted hydrolase of the alpha/beta superfamily [General function prediction only].	2.02065e-28
NZ_LS483441.1|WP_042017039.1|1826284_1828900_-|Fe/S-dependent-2-methylisocitrate-dehydratase-AcnD	gnl|CDD|131386	TIGR02333, 2-methyl_citrate_dehydratase_Fe-S_dependent_AcnD, 2-methylisocitrate dehydratase, Fe/S-dependent. Members of this family appear in an operon for the degradation of propionyl-CoA via 2-methylcitrate. This family is homologous to aconitases A and B and appears to act the part as 2-methylisocitrate dehydratase, the enzyme after PrpD and before PrpB. In Escherichia coli, which lacks a member of this family, 2-methylisocitrate dehydratase activity was traced to aconitase B (TIGR00117) ().	0
NZ_LS483441.1|WP_042016952.1|1832445_1833294_+|taurine-dioxygenase	gnl|CDD|181947	PRK09553, tauD, taurine dioxygenase; Reviewed.	1.34971e-81
NZ_LS483441.1|WP_029314727.1|1816365_1816710_-|TusE/DsrC/DsvC-family-sulfur-relay-protein	gnl|CDD|213798	TIGR03342, dsrC_tusE_dsvC, sulfur relay protein, TusE/DsrC/DsvC family. Members of this protein family may be described as TusE, a partner to TusBCD in a sulfur relay system for 2-thiouridine biosynthesis, a tRNA base modification process. Other members are DsrC, a functionally similar protein in species where the sulfur relay system exists primarily for sulfur metabolism rather than tRNA base modification. Some members of this family are known explicitly as the gamma subunit of sulfite reductases.	4.13527e-64
NZ_LS483441.1|WP_042017038.1|1820048_1821002_-|AraC-family-transcriptional-regulator	gnl|CDD|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	1.08585e-21
NZ_LS483441.1|WP_039038790.1|1830124_1831009_-|methylisocitrate-lyase	gnl|CDD|183086	PRK11320, prpB, 2-methylisocitrate lyase; Provisional.	0
NZ_LS483441.1|WP_042016921.1|1806377_1807100_-|phosphatase-PAP2-family-protein	gnl|CDD|182658	PRK10699, PRK10699, phosphatidylglycerophosphatase B; Provisional.	7.52866e-34
NZ_LS483441.1|WP_042016943.1|1824919_1826119_-|2-methylaconitate-cis-trans-isomerase-PrpF	gnl|CDD|131387	TIGR02334, conserved_hypothetical_protein, probable AcnD-accessory protein PrpF. The 2-methylcitrate cycle is one of at least five degradation pathways for propionate via propionyl-CoA. Degradation of propionate toward pyruvate consumes oxaloacetate and releases succinate. Oxidation of succinate back into oxaloacetate by the TCA cycle makes the 2-methylcitrate pathway a cycle. This family consists of PrpF, an incompletely characterized protein that appears to be an essential accessory protein for the Fe/S-dependent 2-methylisocitrate dehydratase AcnD (TIGR02333). This protein is related to but distinct from FldA (part of pfam04303), a putative fluorene degradation protein of Sphingomonas sp. LB126. [Energy metabolism, Fermentation].	0
NZ_LS483441.1|WP_042016927.1|1809929_1812056_+|pilus-assembly-protein-FimV	gnl|CDD|274615	TIGR03505, FimV_core, FimV N-terminal domain. This region is found at, or about 200 amino acids from, the N-terminus of FimV from Pseudomonas aeruginosa, TspA of Neisseria meningitidis, and related proteins. Disruption of FimV blocks twitching motility from type IV pili; Semmler, et al. suggest a role for this family in peptidoglycan layer remodelling required by type IV fimbrial systems. Most but not all members of this protein family have a C-terminal region recognized by TIGR03504. In between is a highly variable, often repeat-filled region rich in the negatively charged amino acids Asp and Glu.	3.17142e-25
NZ_LS483441.1|WP_042016933.1|1814017_1815277_+|bifunctional-tetrahydrofolate-synthase/dihydrofolate-synthase	gnl|CDD|182774	PRK10846, PRK10846, bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional.	0
NZ_LS483441.1|WP_042016938.1|1821117_1823274_+|TonB-dependent-siderophore-receptor	gnl|CDD|227114	COG4773, FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism].	7.80404e-168

Protein sequences

>NZ_LS483441.1|WP_029314727.1|1816365_1816710_-|TusE/DsrC/DsvC-family-sulfur-relay-protein
MSEAHHLQFNGQLIETDAQGYLRHSEQWSEALALVLAEKEGIVLEDPHWEVVRFVRAFYLEFNTSPAIRALVKAMEKQYGPEKGNSRYLYKLFPEGPAKQATKIAGLPKPVKCI
>NZ_LS483441.1|WP_029314728.1|1815456_1816260_+|cell-division-protein-DedD
MASKFQNRLVGTVILVALVVIFLPDLMDGNKLEQKDEAFAKIPLRPELEPAKPALQVSAASTLPAEHLASQQQASAATQWQVEEIGDTVTLANQGGANPAGASQAPITQQQPVQAVAQPKPQPKPEPKPEVIAKKPVEQPKPKPVPTKPVEVQKPVEAKPQAGQIKTMDDLIASKMAQPTTAPAAAPAQGSWILQLGAFKNADSVNALVSKLRAAGYSAQTSPRTPVQGQINRVFIGPDVSKAKLQGMQSRISQMTGLSGSVVAYNP
>NZ_LS483441.1|WP_042016933.1|1814017_1815277_+|bifunctional-tetrahydrofolate-synthase/dihydrofolate-synthase
MSSHMQQSQSRSLVDWLSYLEQIHPANIDMGLERVGTVARRMGLTELPFKVITVAGTNGKGSSCAMAASILMAAGYRVGVYSSPHLLRFTERVRVNGQELDDGDHCAAFTEVEAARGDIALTFFEFATLAGLWLFRRAAPDVLLLEVGLGGRLDATNVVESDVALITSIALDHCDWLGDTREAVAVEKAGVYRKGKPAISGEPNPPSTIASEAARLGACLRQVGIDYRGDEHEGDWDYHGLHHWSGLPKPALPLMNAVTVLAALESLGLPLAESAIRDGLANARLAGRMQQLQTSPLVIVDVAHNPHSAAYLASQLRQRPGKGKRRAVVGMLKDKDMAGSLAELDGLIDEWFLASLHGPRAATADQLATALGSGRGAALTFASVGDAYGAALAASSPDDMVIVFGSFYTVADVLALGSV
>NZ_LS483441.1|WP_010675139.1|1813151_1814015_+|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta
MSWLEKILPKSKITTPRRHNIPEGVWTKCTACEQVLYRAELERNLEVCPKCDHHMRISARARLESFLDAEGRSEVAAELEPQDILKFKDSKRYKDRLSAAQKETGEKDALVVMKGTLKGVPVVACSFEFSFIGGSMSSVVGARFVRAVEESIKEGRGLVCFSTSGGARMQEALFSLMQMAKTSAALDRLTKAGLPFISVLTDPTMGGVSASLAMLGDINVGEPKALIGFAGPRVIEQTVREKLPEGFQRSEFLLEKGAIDLIIDRREMRNRLAGLLAKLMNTQVIED
>NZ_LS483441.1|WP_042016930.1|1812222_1813032_+|tRNA-pseudouridine(38-40)-synthase-TruA
MRIALGIEYDGSRYFGWQRQREVISVQEELEKALSRIANHPVSIQCAGRTDAGVHATGQVIHFDTESNRAEGAWTLGLNSNLPPDIAVRWVREVDEHFHARFSATARRYRYVIYNHNYRPAILGQGVSHYHEAIDAALMHQAGQSLLGEHDFSTFRAVACQSNTPWRNVTHLCVSRSGPYIVLDIKANAFLHHMVRNITGSLLLVGQGLQPVEWIAEVLAAKDRNLAGPTAKAGGLYLVDVDYPAEFGLPRPPLGPLWLPDSAPGTTSF
>NZ_LS483441.1|WP_042016927.1|1809929_1812056_+|pilus-assembly-protein-FimV
MGHSRITLATLLALGLLGTVQAEEGAREPFFVELKGPDGSPPPAVQPEPRAQPVAPVTLPRAQPIVRQVPAASAGSYGPVRPTDTLWSLASKHRPSNRVSVYQTMVAIYDKNPRSFADGNINHILVGSHILLPTAAEAGRITDAEARRRFNSDNASWKGLSPKYLANKQSHVAQPVVSKPAPAKPAVVAKSTPPKAAPIPAAPKATAPAPEVKETAKAAVSTPVVVSAAASSAASTAPAPLPATAVGKPSTEMALALEDANAQLGQVTEMNHRLKLRLQALTEEVETLKAQLQDQTALQKEVAELKANPTPPVVAPVPKQSWLMELLSSPLNLAMIILLPVLLVLALVTLWLRARARRELEEQEKSLSESTSMVMGDENSEFEQLMTVGIADDEPLHGMPDLNEPEVSRKQDGASAAADVIFRDDETALSAFDVEPAVTTANRDPDLVPELDLAHEGDFDLPVVPELDLSDEPTSSARGHDEIMTEEELQAALFAELDADLEADLAQAQKESRSQRDETLANFDLSDLETGFGEPTDDELATKAPHIDETGFGKDDVDDMLAELGLEPTKPTASEWDPSELALADFEDAFAEVESHQGEVKPREQVQDSDFVEIDKLLADADASSTEQEPYQGFSLDVGLDGFPEVLPESNGFDVDADDGGVGAKLDLARAYLEIDDKESARELLEEAVAQGSEHQRSEAQKLLKRLG
>NZ_LS483441.1|WP_041214974.1|1808619_1809636_+|aspartate-semialdehyde-dehydrogenase
MSQQFNVAVLGASGAVGQAMIEILEERAFPVATLYPLASSRSAGDTVRFGGKNVDILDVEAFDWSQVEIALFSAGAEVSAKWAPIAAEHGCIVIDNTSCFRYDEDIPLVIPEVNPDALADFRNRNIIANPNCSTIQMLVALKPLHDEVGISRINVATYQSVSGSGKEGVSELAGQTAHLLNGRPVEPTLYPQQIAFNLIPQIDAFTDNGYTREEMKMVWETQKILGDASIAVNPTCVRVPVFYGHAEAVHVELHQPLDAEQVKELLRNAPGVTLFDDEGDYPTPVRDATGQDDVMVGRVRQDISHPSGINMWIVADNVRKGAATNSVQIAELLVRDYL
>NZ_LS483441.1|WP_042016923.1|1807350_1808472_+|4-phosphoerythronate-dehydrogenase
MKIVVDENMPHAVELFAEFGEVVPLPGREIKAADLQEADVLLVRSVTRVNEALLASCPRLGFVGTATIGTDHIDQGLLAARGIPFFSAPGCNKVSVGDYVLSALLVLAERHELTLSEMSLAVIGAGNTGESVAGKAEALGMKVLRCDPPLARSGAAGDFVDFRTALDADIVSFHVPYLREGDEATFHLLGVEEIAERPAGQILINASRGEVWDNRALLVRQQGPHPLRLVMDVWEGEPEPLKELVPHTELATPHIAGYSLEGKARGTWMLYEALCRQLGRTPRQDLQSLLPAPEVRELTPGQPADQALIKQLVHLVYDVRRDDARFRNRIGLPGSFDEQRKRYPERRELGALQLKGPFADDRLARLGFAVSKQ
>NZ_LS483441.1|WP_042016921.1|1806377_1807100_-|phosphatase-PAP2-family-protein
MPTHSSSLPRRKVLHFNALLLLPLLLLVCLPWQPFMTQALQSGWLWWPYALTRMVDLPGLVFTIAALLLLTRHKLTLDGRAILALAGALFAVLASDWVIKSLIKLLTEEPRPYLIWLESQELIPAIRQFYGGSQALRSEQVHAATQLLALPAWLGQHWQAEVNYAFPSGHSIAAMSLAQFFGLIWLARAPAGAWLLPLWAIGIGLSRTLIGMHWPLDVLASALLGSLTALLAARWWLRHY
>NZ_LS483441.1|WP_010675145.1|1805502_1806324_+|membrane-protein
MQRRSFFTLSALALLASSLPLSAFAIDEAKKEIVIGTTVGDFADMVTDAIKPQLEAKGYKVKLVEFTDYVTPNIALADGSLDVNCFQHKPYLESFAKDRGLSLAPITQVPTGPMGLYAGKLGDLKAVKEGSTVAIPNDPTNQARALLMLQDLGWLSLKEGINPLKASEFDVVKNPHNLKLVLLEAAQLPRSREDVDFSVINGNFAASSGIPFSSGLFLERSYDFINWVVVKSADAGKPFAKDVAAAYNSPEFKAYAAKRFVGYKYPEGWQQKG
>NZ_LS483441.1|WP_010675134.1|1819228_1819885_-|Bax-inhibitor-1/YccA-family-protein
MDTRSIYTGTQGAVRDTNKVLRNTYMLLSLTLGFSAVVAGVATVMNMPPLHWAVFLIGVYGLMFLTEKNRDNGMGLVFTFALTGLLGYSLGPIINMYMNNGGGEIVMTALGGTALTFFGLSAYALTTKRDLSFLGGMLFVGFWVLLVAMVANIFLQMSALSLALSAMFMLFSSGAILLTTQQIVRGGETNYISATVTLYVSIYNIFLSLLSLLGGNRN
>NZ_LS483441.1|WP_042017038.1|1820048_1821002_-|AraC-family-transcriptional-regulator
MVKLHMTDTVARDTSARQRGRFTGRVENLVIQEGLRFHNKDIVHKADFATERELPPQLIIAIPLESRALMTYGATHRLKGCRFHESDPIVATAILYTEPDIVQGAAKAQVRSRSIVLSLDHTWLAHNLAQAHRKAFAQTFSRHLSRVDWTLPAALGQIAEALNLTSSQNASEMLMRKAFALSVWESLMTHLQQAASPCCQRQNEQPTRLKMLLRDEKVDEMTLTEIAATLGMSVSTLQRAAKKELGMSLQRYLRQRKLQEARARLEARSLSLQGAAAHAGYDHVANFITAFRKQFGFSPTRIAKQGKEQEQAPSATP
>NZ_LS483441.1|WP_042016938.1|1821117_1823274_+|TonB-dependent-siderophore-receptor
MVVLKDKARSPLALAISAALAVTFAAPAGAHTPDIKPDETLVVYGNPLYGMSPSEETGGYGVDSATVGTKTPAALKDIPQSITVLTNDYIEERNFVAVDDLAKYTPGLRTLVNDSGRSSIFSRGYEYDEVNLNGLPSPMQSKYGTLPSLAAVDRVEIMRGPSGLFNSTSELGGVINMVLKRPTDAFKGSVTARYGSWDRHYLEADMGGALNDEGSLRGRVVVANADIKNQVDYNNNDNGTYYGTLEFDLSDRTRLSVYALHQTKDILPTNGLPAYKDGSLLDIGRSTYLGSAEDFFDADTTDVGASLQHAFANGGVGQVSARYMDHDMRLEQTFTNGPVDAAGNTGLMFNGQGNQQKNMAFDANYSQMFDLLGHKSEFVLGSDYKRYESDIQTYTNRNLGKINVFDFDPTRVAKPDYSYTKNDHEEQSELGLYGKVSWRLLEPLAVITGARVSWYDLDAVSTTLSSGAQSGESSAFNGKLTPYAGAVYDLSDEHAWYASYSKVFKPQTSQDESGNLLKPREGSQWETGIKSSLRDGLLNTRATLFLMKDDNIAAQAYDDQGIAITNTYWATGKVETQGVELEASGYLSQNWMVMAGYTFTDIEEKAGDHNPKFDTIPRHALSLWTDYHLADWVQGLHLGAGMTAVSDYGFNQKGVETHQGGYALFDAAVRYEINDRMQATLNLYNLLDREYFYRVGSTSTFNMYGEPANLMAGFTYKL
>NZ_LS483441.1|WP_042016940.1|1823371_1824418_+|alpha/beta-hydrolase
MTRLIILLLTMITLSSAQADMLHYAQRFTHHSALLGETRQYSVSLPQEYEREPGARFPVLYLLDGEKSLLEVVGITRALRAGLNPAIPPLIIVAVHNTDRMRDYTPSHTMTLPNGSPAGPGYAVTGGGPRFLRYLSEELRPLIEERFRTRAPALLVGHSLGGLLALDAQAQDGGQFQGVIAIDASLWFDYPRNYERIASELTGPLKHASSLFMAVANNPFTPGFGRSAFHRDRLQQFARQVVAAPGANLNVTSRYFEEEDHHSVYHPAVYQGLQWLFQGYRLDLAPGHFSRQGVIARFDALNRHLGSALRPELGSLRDIREKAVRWPQMAISVDEADALLTHYYGSKP
>NZ_LS483441.1|WP_042016943.1|1824919_1826119_-|2-methylaconitate-cis-trans-isomerase-PrpF
MAHQPQVKIPATYLRGGTSKGVFFRLSDLPERCQQPGPARDAFFLRVIGSPDPYGAHMDGMGGATSSTAKCVILSKSQQPDHDVDYLYGQVAIDKAFVDWSGNCGNLSTGAGAFAIHAGLVDPSRIPESGTCEVRIWQANIGKTILAHVPVTNGQVQETGDFELDGVTFPAAEIVLEFLDPSDEGEEGGALFPTGNLVDDLEVPASVVKSGVLKATLISAGIPTVFVNAEDIGYEGTELREAINTDPQALARFEAIRVAGALRMGLIKRPEEAATRQHTPKIAFVAPAKDYRTASGKEIIAGEIDLLVRALSMGKLHHAMMGTCAVAIGTAAAIPGTLVNLAAGGGEREAVRFGHPSGTLRVGAQAEQVAGQWTVTKAVMSRSARILMEGWVRVPGDAF
>NZ_LS483441.1|WP_042017039.1|1826284_1828900_-|Fe/S-dependent-2-methylisocitrate-dehydratase-AcnD
MNAQYRKPLPGTALDYFDAREAVNAIAPGAWDRLSYTARVHAENLVRKCEPAILGECLGQIVHNKRDRDFPWFPARVVCHDILGQTALVDLAGLRDAIAEQGGDPAQVNPVVPVQLIVDHSLAVECGGFDPQAFEKNRAIEDRRNEDRFHFINWTKQAFKNIEVIPPGNGIMHQINLEKMSPVIHADRGLAYPDTCVGTDSHTPHVDALGVIAVGVGGLEAENVMLGRASWMRLPSIVGVELSGKPQPGITATDLVLSLTEFLRQQKVVGAYLEFRGEGAAALTLGDRATISNMAPEYGATAAMFFIDQQTLDYLRLTGRDDDQVKLVETYAREAGLWADALASAQYERVLYFDLSTVVRTLAGPSNPHRRLPVSALAERGIAVDLDKARAQEADGLLPDGAVIIAAITSCTNTSNPRNVIAAGLLARNANRLGLVRKPWVKSSLAPGSKTVALYLKEAGLDEELEQLGFGVVAFACTTCNGMSGALDPAIQQEIIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTIRFDIEKDVLGVVNGKEIRLKDIWPSDEEIDAVVRAAVKPAQFRQVYIPMFTIEEDLGPKVAPLYDWRPQSTYIRRPPYWEGALAGERTLKGMRPLALLPDNITTDHLSPSNAILRSSAAGEYLHKMGLPEEDFNSYATHRGDHLTAQRATFANPQLVNEMAVVNGAVKKGSLARVEPEGRVMRMWEAIETYMERKQPLIIVAGADYGQGSSRDWAAKGVRLAGVEVIAAEGFERIHRTNLIGMGVLPLEFKPGTTRLTLGLDGTETYDVVGERQPHTDLTLVIRRRSGEVIQVPMTCRLDTAEEVSVYEAGGVLQRFAQDFLASTAQKAAS
>NZ_LS483441.1|WP_042016946.1|1828902_1830060_-|2-methylcitrate-synthase
MSAIPETTGFKPKKSVALSGTAAGNTALCTVGLSGNDLHYRGYDILDVATSCEFEEIAHLLVHGHLPNVAELAAYKAKLKALRGLPTGVKTALEQLPPSAHPMDVMRTAVSVLGCLSPEKDDHNHPGARDIADKLMACLGSVLLYWYHFSHNGKRIHVETDDDSIGGHFLHLLHGEKPRDSWVRAMHTSLILYAEHEFNASTFTGRVIAGTGSDMYSCITGAIGALRGPKHGGANEVAFEIQKRYENPDEAEADIRARIEKKEVVIGFGHPVYTVSDPRNKVIKEVARALSQEQHNTKMFDIAERLESTMWEAKKMFPNLDWFSAVSYHMMGVPTAMFTPLFVIARTSGWSAHVIEQRIDGKIIRPSANYVGPEDLVFVPLKERK
>NZ_LS483441.1|WP_039038790.1|1830124_1831009_-|methylisocitrate-lyase
MSNLSPSAGTRFRTALANEKPLQIVGTINAYMALMAERSGFKALYLSGAGVANASFGLPDLGMTSMNDVLIDAERITAATQVPLLVDIDTGWGGAFNIARTVRAFERGGVAAVHMEDQVAQKRCGHRPNKAVVSLSEMVDRIKAAVDARQDESFVIMARTDALAVEGLGSALERAAAYVEAGADMIFAEAVTELDQYDRFKQAAGVPILANMTEFGKTELFDKEALALHGVDMVLYPLSAARAANQAALNVYQQLRRDGHQRAVVDTMQTRESLYDFLGYHHYEQTLDRLFTKE
>NZ_LS483441.1|WP_042016948.1|1831390_1832371_+|quinone-oxidoreductase
MANAIRFYETGGPEVLRYEQVAVGEPGPGQVRLRHAAVGLNYADTYFRNGTYPIPMPNGLGVEAAGVVEAVGEGVTNVDVGDRVTYTGFINTLGAYSTERLIPAAPLIRLPDSISCETAAAMTMRGLTSAYLMRRIHAFKPGDSILLHAAAGGVGLIVAQWAKLLGLTVIGTVSSGAKAELARAHGCDFTIDYSREDVATRVRALTGGAGVDVVFDSVGKNTFLGSLDSLKRRGLMVCVGTASGPIDGFNPQLLAMKGSLYLTRPALADYIADPAEKEALAGELFDHVASGRIKIEVNQKYELQDAAQAHRDLESRQTTGSSVFII
>NZ_LS483441.1|WP_042016952.1|1832445_1833294_+|taurine-dioxygenase
MRVEQLTCHIGAELSGVQLADAAHDAGLFTEIRAQLLRHKVLFLRNQEMSRSDHVTFARRFGELEDHPVAGSDPDHPGLVRIYKSPDVPNDRYENAWHTDATWREQPPMGCVLRCVECPPVGGDTLWANMAAVYAALPEEIKQKIAGLRARHSIEASFGAAMPMEKRLALKAMFPDAEHPVVRTHPETDEKILFVNAFATHFTNYHTPANVRVGQDYTMGGSDLLRYLISQAYIPEFQVRWRWQPGSVAIWDNRSTQHYAAMDYAPCHRKMERAGIMGDTPY

Crispr_ID: NZ_LS483441_6

• CRISPR_ID: NZ_LS483441_6
• CRISPR_location: 3084876-3084976
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_LS483441_6

Consensus_repeat	Method
ATTGTCGGCCTGAGCTGACGCGC	CRISPRCasFinder

spacers of NZ_LS483441_6

>6.1|3084899|55|NZ_LS483441|CRISPRCasFinder
AGGCTGGCAGCCTGTCCTCCCTGAACACCATATGGACATCGACGATGACGGGGAG

CRISPR arrays and Neighbor proteins around NZ_LS483441_6

CRISPR arrays

The CRISPR arrays of NZ_LS483441_6

>merge|NZ_LS483441|6|3084876-3084976|CRISPRCasFinder
ATTGTCGGCCTGAGCTGACGCGCAGGCTGGCAGCCTGTCCTCCCTGAACACCATATGGACATCGACGATGACGGGGAGATTGTCGGCCTGAGCTGACGGCG

>NZ_LS483441|6|5|3084876-3084976|CRISPRCasFinder
ATTGTCGGCCTGAGCTGACGCGC	AGGCTGGCAGCCTGTCCTCCCTGAACACCATATGGACATCGACGATGACGGGGAG
ATTGTCGGCCTGAGCTGACGGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LS483441.1|WP_010674171.1|3086951_3087608_-|GTP-cyclohydrolase-I-FolE	unknown	unknown	gnl|CDD|236472
NZ_LS483441.1|WP_010674179.1|3078761_3079073_-|SelT/SelW/SelH-family-protein	unknown	unknown	gnl|CDD|226057
NZ_LS483441.1|WP_042017451.1|3082691_3083093_-|hypothetical-protein	unknown	unknown	unknown
NZ_LS483441.1|WP_042017455.1|3089201_3089957_+|molybdopterin-synthase-adenylyltransferase-MoeB	unknown	unknown	gnl|CDD|180204
NZ_LS483441.1|WP_029314286.1|3072714_3074616_-|biosynthetic-arginine-decarboxylase	unknown	unknown	gnl|CDD|235427
NZ_LS483441.1|WP_042017460.1|3094697_3095420_-|molybdate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270257
NZ_LS483441.1|WP_042017450.1|3080376_3081111_-|hypothetical-protein	unknown	unknown	unknown
NZ_LS483441.1|WP_042017445.1|3072269_3072458_-|hypothetical-protein	unknown	unknown	unknown
NZ_LS483441.1|WP_010674165.1|3093893_3094574_-|molybdate-ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|226629
NZ_LS483441.1|WP_039038856.1|3081780_3082683_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|176114
NZ_LS483441.1|WP_042017454.1|3085051_3086701_-|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl|CDD|223910
NZ_LS483441.1|WP_010674176.1|3081110_3081671_-|hypothetical-protein	unknown	unknown	gnl|CDD|179642
NZ_LS483441.1|WP_042017448.1|3079069_3080191_-|adenosylhomocysteinase	unknown	unknown	gnl|CDD|198065
NZ_LS483441.1|WP_042017457.1|3091997_3092774_-|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|274729
NZ_LS483441.1|WP_042017446.1|3075641_3076868_+|peptidase-T	unknown	unknown	gnl|CDD|235484
NZ_LS483441.1|WP_042017482.1|3090035_3090764_-|hypothetical-protein	unknown	unknown	unknown
NZ_LS483441.1|WP_042017459.1|3092841_3093897_-|molybdenum-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|131197
NZ_LS483441.1|WP_042017456.1|3090840_3091866_-|StbA-family-protein	unknown	unknown	gnl|CDD|310773
NZ_LS483441.1|WP_042017480.1|3087978_3089205_+|molybdopterin-molybdotransferase-MoeA	unknown	unknown	gnl|CDD|182643
NZ_LS483441.1|WP_039038860.1|3076973_3078698_+|lysophospholipid-acyltransferase-family-protein	unknown	unknown	gnl|CDD|153248

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_LS483441.1|WP_010674171.1|3086951_3087608_-|GTP-cyclohydrolase-I-FolE	gnl|CDD|236472	PRK09347, folE, GTP cyclohydrolase I; Provisional.	1.23852e-103
NZ_LS483441.1|WP_010674179.1|3078761_3079073_-|SelT/SelW/SelH-family-protein	gnl|CDD|226057	COG3526, COG3526, Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones].	9.71564e-50
NZ_LS483441.1|WP_029314286.1|3072714_3074616_-|biosynthetic-arginine-decarboxylase	gnl|CDD|235427	PRK05354, PRK05354, biosynthetic arginine decarboxylase.	0
NZ_LS483441.1|WP_042017460.1|3094697_3095420_-|molybdate-ABC-transporter-substrate-binding-protein	gnl|CDD|270257	cd13539, PBP2_AvModA, Substrate binding domain of ModA/WtpA from Azotobacter vinelandii and its closest homologs;the type 2 periplasmic binding protein fold. This subfamily contains domains found in ModA proteins that serve as initial receptors in the ABC transport of molybdate in eubacteria and archaea. Bacteria and archaea import molybdenum and tungsten from the environment in the form of the oxyanions molybdate (MoO(4) (2-)) and tungstate (WO(4) (2-)). After binding molybdate with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. In contrast to the structure of the two ModA homologs from Escherichia coli and Azotobacter vinelandii, where the oxygen atoms are tetrahedrally arranged around the metal center, the structure of Pyrococcus furiosus ModA/WtpA (PfModA) has shown that a binding site for molybdate and tungstate is where the central metal atom is in a hexacoordinate configuration. This octahedral geometry was rather unexpected. The ModA proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	6.19968e-74
NZ_LS483441.1|WP_010674165.1|3093893_3094574_-|molybdate-ABC-transporter-permease-subunit	gnl|CDD|226629	COG4149, ModC, ABC-type molybdate transport system, permease component [Inorganic ion transport and metabolism].	6.59306e-76
NZ_LS483441.1|WP_039038856.1|3081780_3082683_+|LysR-family-transcriptional-regulator	gnl|CDD|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.4053e-98
NZ_LS483441.1|WP_042017454.1|3085051_3086701_-|methyl-accepting-chemotaxis-protein	gnl|CDD|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	3.75892e-72
NZ_LS483441.1|WP_010674176.1|3081110_3081671_-|hypothetical-protein	gnl|CDD|179642	PRK03757, PRK03757, YceI family protein.	2.81547e-78
NZ_LS483441.1|WP_042017448.1|3079069_3080191_-|adenosylhomocysteinase	gnl|CDD|198065	smart00997, AdoHcyase_NAD, S-adenosyl-L-homocysteine hydrolase, NAD binding domain.	2.78548e-44
NZ_LS483441.1|WP_042017457.1|3091997_3092774_-|alpha/beta-fold-hydrolase	gnl|CDD|274729	TIGR03695, menH_SHCHC, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase. This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	1.62823e-23
NZ_LS483441.1|WP_042017446.1|3075641_3076868_+|peptidase-T	gnl|CDD|235484	PRK05469, PRK05469, tripeptide aminopeptidase PepT.	0
NZ_LS483441.1|WP_042017456.1|3090840_3091866_-|StbA-family-protein	gnl|CDD|310773	pfam06406, StbA, StbA protein. This family consists of several bacterial StbA plasmid stability proteins.	5.76592e-102
NZ_LS483441.1|WP_042017459.1|3092841_3093897_-|molybdenum-ABC-transporter-ATP-binding-protein	gnl|CDD|131197	TIGR02142, Molybdenum_import_ATP-binding_protein_ModC, molybdenum ABC transporter, ATP-binding protein. This model represents the ATP-binding cassette (ABC) protein of the three subunit molybdate ABC transporter. The three proteins of this complex are homologous to proteins of the sulfate ABC transporter. Molybdenum may be used in nitrogenases of nitrogen-fixing bacteria and in molybdopterin cofactors. In some cases, molybdate may be transported by a sulfate transporter rather than by a specific molybdate transporter. [Transport and binding proteins, Anions].	1.0699e-93
NZ_LS483441.1|WP_039038860.1|3076973_3078698_+|lysophospholipid-acyltransferase-family-protein	gnl|CDD|153248	cd07986, LPLAT_ACT14924-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.	2.1811e-69
NZ_LS483441.1|WP_042017480.1|3087978_3089205_+|molybdopterin-molybdotransferase-MoeA	gnl|CDD|182643	PRK10680, PRK10680, molybdopterin biosynthesis protein MoeA; Provisional.	0
NZ_LS483441.1|WP_042017455.1|3089201_3089957_+|molybdopterin-synthase-adenylyltransferase-MoeB	gnl|CDD|180204	PRK05690, PRK05690, molybdopterin biosynthesis protein MoeB; Provisional.	9.19201e-155

Protein sequences

>NZ_LS483441.1|WP_042017451.1|3082691_3083093_-|hypothetical-protein
MSNTILSGSREPHQSPILLDLNVLYHPPKRPLTALGIVSAFIPLFGYGWQAMTQDPETHFRHELGKRINKHKSDEANLALMMQLAAMLDCHCLHVTLPYALGEAELAALRQRLPRWQMSQQDHLLVAELMPTP
>NZ_LS483441.1|WP_039038856.1|3081780_3082683_+|LysR-family-transcriptional-regulator
MDQIAAMRTFIKVVECQSFTKAAHQLGISVAMTSKLMQQLEESLSTRLLSRTTRQVNPTEAGQFYYQRSLALLAELEETHSQLTHNNQQPQGTLKLSVPMDFGYLHLSPALPLFRERYPDLKLEIEYSDRRVALVEEGFDLALRIGNLPDSSLVAKPLAMMKMVVCASPDYLARRGRPKTPEDLKQHDCLIYTLTQPDWVFKRDGEEHSIRPQGPLRANNGVALTRAACDHQGIILQPTFIVGDALRSGALVPLLLEWEKGQVGLYALYPHRRFVSAKVRCFIEFVQERYLAPHYWDRET
>NZ_LS483441.1|WP_010674176.1|3081110_3081671_-|hypothetical-protein
MKMTKALLASCLFMAAPLMAADYDVDAAHTTVQFKVGHLGFSELVGRFNTFSGTFSMDDANPAAAKASFEIDAASVDSNHEARDKHLRSPDFLDVKQYPKMTFVSTGYEGTKDKGVLKGTLTLHGVSKDVAFDLVHIGEGKDPWGGYRSGFNATTTIKRSEFGVNYMVPNIPDEMTINLFVEGVRK
>NZ_LS483441.1|WP_042017450.1|3080376_3081111_-|hypothetical-protein
MGAALLLQTLAAPLGAALLSWRWPRLGYLWGALGIWLVGCLLGGAYGLPVKAWQWLPLTLLVPALTQGTSKGVALALFGVLGALVWWQGLASVLASEPGIWLALLPAILWSGWTSWRGDSEEGLGFTLAFIWLALVIGIDGSLLIAQLTGALAAFAGFRALLGAFAGVKVTPAALGLALAFVQMLAWQYVEVPLLVLLPVWLLPLLERALHGRPGLSRWGVLILVAAVGAGVSLWWVWPEASLY
>NZ_LS483441.1|WP_042017448.1|3079069_3080191_-|adenosylhomocysteinase
MHSQGSEHLFFRHFTEQGCLGDLCILLVTHLLPDRPDFIQVLDRVGRVGAILPKPKSVHGPTLTWAQQHYPVLPLNRHWTSDPGEVIAQIAPLVMSHERLIILDIGGYFAKSQAVLAEHFGARFIGVVEMTENGHQRYEQESLAAPVISVARSPLKQAEDIQIGLSVVYSAESLARTLRRTFNVCQAALFGYGKVGRSIARELRCRNLHLELVETDALRQVEALSHGFKLVNKAEALGRAELVICSTGNGSLDITDLQALRPGAMLASVTSADDEFAFSLAQLPWPSEEVCPHVLALTRPDGSTIFLLNRGEAVNFVHGAVIGEYVYLVLAEIIEGVHQLAHQASTPGLHELPQATMQRIARHWLTDFHGVTP
>NZ_LS483441.1|WP_010674179.1|3078761_3079073_-|SelT/SelW/SelH-family-protein
MTDTHLPLAKPRIEIRYCTLCRWMLRAAWLAQELLSTFDGELGEVALVPASKGEFRILVDGVLVWDRVADEGFPEAKEIKQRVRDVIAPERDLGHADRKPAAE
>NZ_LS483441.1|WP_039038860.1|3076973_3078698_+|lysophospholipid-acyltransferase-family-protein
MFDVDTLLGQHLPHLASQPLLRPLMRQGLRWLLHEEAFTRFAARHPHLRGLDFVEQALTELHFDYRVSEAELEHIPASGRVILVANHPIGSLDGLALLRLIGRIRPDVKIVANQVLAQLAPLRPLLLPVDNLGGKTDRQAILAMNEHLAADGALVIFPAGEVSRLGPKGVKDGPWQAGFIKLAQRSRTPLVPIHLGGRNSLWFYLASWLNKPASALLLVRQLFRQQGQTLPVTIGARIPLASFQELPAKTAARLVRGHLYRIARGKAGRLQTEAPIALPEDRRLLKQAIDGCELLGQTPDGQRILLYRRHEQSHSVILRELGRLREIAFRAVGEGSGKRRDLDAFDDDYHHLILWDPARLDIIGAYRFAPVAERLASKGLDGLYSHTLFGFEEKLLPRLEQAIELGRSFIQPAYWGKRGLDYLWFGIGAYLARYPQYRYLFGPVTLSGSLPPAAKDLLVSFYRQHFAPALALAPSRRPYPATPTLFEGRDYGDDLKVLKAGLDNLGCAIPTLYKQYAELCEPGGVQFMDFGIDPDFNHCIDGLVWVDVSRIKPHKRARYIGLPAGEALATSGDR
>NZ_LS483441.1|WP_042017446.1|3075641_3076868_+|peptidase-T
MNTLLSRFLHYLTFHTRSDATNPACPSSEGQRLFARALCDEMTQMGLSQVTLDEHGYLTACLPGNQPDAPAIGLIAHMDTADYEAECVVPQIVENYQGGDICLGKGDEVLAIRQYRFLKNYLGQDLITTDGTTLLGADDKAGIAEILTAVEYLQAHPEIPRGDVWVGFTPDEEIGRGADRFPLERFPAKWAYTVDGGELGELECENFNAASATVRITGNNVHPGTAKGSMINSQTLAARFHTAMPAEQTPECTQGYEGFFHLARMEGTVEETTLHYLIRDFDDDCFAARKAQLKERVASLQLDAPKARITLEIVDNYRNMRSQIAPHPHIVELAKAAMEAADVVPKIKPIRGGTDGARLSFMGLPCPNLFTGGHNFHGKHEFIPLQSMEKAVATLVALVRLTSAWRAE
>NZ_LS483441.1|WP_029314286.1|3072714_3074616_-|biosynthetic-arginine-decarboxylase
MTNWSSKDSLKVYNVPYWGAGFFNINDAGHVTVSPDKSRPEAQIVLSEAIEQLRQSGLTTPVLLRFPDILKSRVDALFNAFGQAIEKSGYEGDYLCVYPIKVNQQRRVIETISQSYSDKPRLGLEAGSKPELLAVLSHHHEQGSVIVCNGYKDREYIRHALLGNLMGHKVYIVVEKPSELEMVLDESARLNIKPNIGVRARLASTGSGMWESSGGSMSKFGLSASQILALVERLRSLGKLDCLQLLHFHLGSQIANIRDIQGGIRECGRFYAELCRLGAKVEVVDVGGGLGVDYEGTRSQSHCSANYSLSEYANNVVWGIGDVCREFDLPHPTIISESGRALTAHHAVLVTNIIGAEGVEVNDISAPDEDAPTILQNMWKGWLDLRGEDPSLLEIFHDSVADLGDVNAQYTMGLLNLEQRAWAEMLHQNTCLALKELLNPVNRNHRALADELSEKLADKCFANFSLFQSLPDAWGIGQVFPVMPLAGLDRPLTRRGILMDITCDSDGQVEHYVDGLGVESTLPMPVYGEHEECHVGFFLVGAYQEILGDLHNLFGDTHCAEVWLDEEGKMDIRNVVRGDTVDQLLRYVNIDPSVIRENYQRIVSHPALDDETRKALLDELELGLQGYAYLEDE
>NZ_LS483441.1|WP_042017445.1|3072269_3072458_-|hypothetical-protein
MELKRDPRCYTDVCIDGKWYHYDHCSTHVYMLMGGAAPSLQLAHEPGSEEELVAMLRQHPQR
>NZ_LS483441.1|WP_042017454.1|3085051_3086701_-|methyl-accepting-chemotaxis-protein
MNTMTIGKKLTAGFAVLGLMMAFIGGFSLFEFSKMNRAAIGFTDSILPAVVRTSTLGETINALRRYELDVFLVADDAQQKARYRNESEKSLQEAARQIVAHDGTIWAEDREERRAFDIVKADWDRYIALHQRIRQMQDSGQMAEAQHLFMGEGVTLYTNLTKSVGELIRINHGYSVGSRAEVVDAFDSAKLSVTLALVIGLALVVALSVVLTRQIRDPLIMLARQAQRIASGDLGRGELQEWVRGNRFNRDELGQLGSAIDRMQGALAELVSEISGSVSQLSSAVEEVSAISEQSAKGMASQQGEVSQVATAMNEMQSTVNEVARNTTDAMGAAKQASRTSTQGNQVVRSAIGSIEQVSRQIEQAGSVVQQLETDSASISMVLDVIRGIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRSLAQRTQASTAEISKMIEVLQERTAEAGSAMQLSRQQMQESVELAREAGSSIDSINGAVTQITDMNTLIATATEQQNAVTEELNRSIVKIHTAADENAQGAQQTAQACVELSKLANTLHHMTQRFTL
>NZ_LS483441.1|WP_010674171.1|3086951_3087608_-|GTP-cyclohydrolase-I-FolE
MTSLSQEALLVRAALEAEGLETPLVANELSGQQKKEKIEGHMRAIMETLGLDLADDSLAETPHRIAKMYVNEIFSGLDYATFPKVTVIENKMKVDEMIMVRDISLTSTCEHHFVTIDGFAHVAYIPRGKVIGLSKINRIVQFFARRPQVQERLTQQILLALQTLLGTRDVAISIKATHFCVKARGVMDSTSYTTTTSLGGVFKTQPDTRAEFLGGLKG
>NZ_LS483441.1|WP_042017480.1|3087978_3089205_+|molybdopterin-molybdotransferase-MoeA
MGFDTGALLPLDKALQGMLEQLTCCCETEQLPLPQALDRILAEEISSPLFVPPFDNAAMDGYAVRLADLAAGVPLPVAGKAFAGQPYEGEWPAGHCIRIMTGAPVPPGADAVVMQEETQAGDNGITFLTAPTPGQNIRRRGEDLAQGAQVLESGLRLSPRELPLLASLGIANVTVRRPLKVAIFSTGDELKPLGTPLQHGDIYDSNRYGVKAMLSRMGCECLDLGIIPDDPAALRAAFLQADREADALITTGGVSVGEADFTKQLLEELGEIGFWKLAIKPGKPFAFGRLPNAWFFGLPGNPVSAMVTFDQLVQPALARLAGQQFARPHPLQALATEPLKKSPGRLDFQRGILSVGPNGLEVRSTGSQDSGVFSSLSRANCYIVLEQERGKVAAGETVTVEPFSGLLL
>NZ_LS483441.1|WP_042017455.1|3089201_3089957_+|molybdopterin-synthase-adenylyltransferase-MoeB
MSEILSDAELLRYNRQIVLKSFDFEGQEALKQSRVLVIGAGGLGCAASQYLAVAGVGHLTLVDFDRVELSNLQRQVLHSDERIGQLKVESAATSLRALTPWLEVETHAALADEALLDALLPGHQLVLDCTDNVAIRNLLNQRARQHKVPLVSGAAIRLEGQLCSFTWQDDEPCYACLSALFGDQALTCVEAGVLAPVVGLVGSLQALEAIKLLAGLGKSYSGRLLVIDGLGGSFRELKLPKRPDCPVCSRP
>NZ_LS483441.1|WP_042017482.1|3090035_3090764_-|hypothetical-protein
MQSWYQRARKIQDDVEEFDFSKSRFHKDIYLSGMFLYVLAPSLCKGMANAFGPEQVNLSTLRHVFASCGFELGEGSAPVATDTLIDEIVARLAPQLGQGDNRGLADEIVQRLGQQAAAPLPDSLVDEIVSRIGEQQPTGLWDELKQGLPAPLDHDLLAEAIAGKLPTAGGEADLAPLAGSIQLLSRQLEEQSRLIREQHRLIQRLASQPVRGAGSSELAEPLIEDLSNQVASMKKVKAKGIF
>NZ_LS483441.1|WP_042017456.1|3090840_3091866_-|StbA-family-protein
MAIDDGSTNVKVSWIENKVLKTIISPNSFRKDWKSAALRKDKKIYNYEIGNTKYTYDATSDKSLATTHVEYQYDDLNLLSVHHALLQTGVTPCDVAITVTLPITEFYNPDDCQRNEEKIEKKRRNLMRAISLNKGELFNIVSVEVMPESLPAALSRLIGSGCNEFTKTLVIDCGGTTLDMGIIVGEFDDVSDVYGNNEIGVSMVTDATRKALAAADSDSSYLVANEFIKRRHDMNFVRDVVNDESQIPKILEKMQNKIDELGSQVAHEAKKFAKNPNRIYLVGGGASLIVDAIKAAYPTLGERVELLDDAQSALAREICLYTTEEEEVYREAPVMAEVGDE
>NZ_LS483441.1|WP_042017457.1|3091997_3092774_-|alpha/beta-fold-hydrolase
MRRNQVMKSHGLALRSAGEGPLLLLLHGLGSSSLDWQAQIERFSERYRVVAIDLRGHGQSMQEGPFDVPTLAADVARWLDEQPEPAWVVGLSLGAMVALELALQLPHKVQGLVLVNGFSEFLLETPKEQERYAMRLKWLRWFGMRPLAWWLGRELFPGPDLAQVRHTFRGRFVRNKKKTYKALLEALPGWSVRARLGTLWQPVAIISTSHDYLPLARRVEQFASLPNATIHTPDGHHAWPAEDPAGFNHLLHRILETH
>NZ_LS483441.1|WP_042017459.1|3092841_3093897_-|molybdenum-ABC-transporter-ATP-binding-protein
MSLYLKARRDFGPFTLACDLALPPSRILGLFGPSGCGKSTLLRIIAGLDKAPGDALRWQGRELAALPPEARRIGLVFQDARLFPHLSVLGNLQLAARKGRGRWQPEDLAARLGFAELLGQPAHGLSGGQRQRVALARALLAEPDLLLLDEPFSALDRRSRIHQAHVLKGLQQESGIAMIFVSHAMEEVSLLCDGLVLLAEGRVEAQGTPEEIFARTDLSLASRDDVGVMLSATLAHYDEHEQMATLRLGDQTLMVTMEHAPDEAGPLQIKVAARDLVIATEPIVHSSLSNCLETRLLEVREVRPGQTLLQLALGQQILLARITSRSAQRLALTPAMRLYAYIKAVSLVGEG
>NZ_LS483441.1|WP_010674165.1|3093893_3094574_-|molybdate-ABC-transporter-permease-subunit
MSEGDLLAVWLTLKLAASTTAILLLLSPPLAWWLSRSQHRLRPLVEAMVALPLVLPPTVLGFYLLLAFSPEYGLGGWWRETFGAPLAFSFLGLLIASVIYSLPFVVQPLTSAFVNMGNKELEAAATLGMGPFERFFRIILPMTLPSFVMAAALGFAHTLGEFGVVLMIGGNIPGETQVLSIALFDHVEAMDYQNAHILAGGLMGFSLVMLVLVYGVLQRRQRRLFG
>NZ_LS483441.1|WP_042017460.1|3094697_3095420_-|molybdate-ABC-transporter-substrate-binding-protein
MKRWVSLLVLGAGAMYSGAVLADEVKVAVAANFKGTIERIGKEFTAKTGHSVVISSAATGVLYTQITHGAPFDLFLSADVATPQKLESEGKGSERFTYAIGQLGLWQKGGPAPDEATLRHWQGELAIANPKTAPYGAAAMATLAHLKIDPKQYRVLTGTNISQTWQFVDTGNAKLGFVAWANLVEAGKTGEAWAVPASFYPPIEQQALVLKKGAAVDALVAWLKGPGQAQIKAAGYALPQ

Crispr_ID: NZ_LS483441_7

• CRISPR_ID: NZ_LS483441_7
• CRISPR_location: 3170993-3171128
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_LS483441_7

Consensus_repeat	Method
CGGAGCCGGGGAAGAGGGCCGTTGTGGTCGCCCTCCCCTT	CRISPRCasFinder

spacers of NZ_LS483441_7

>7.1|3171033|56|NZ_LS483441|CRISPRCasFinder
GCCCTGGGGGATCACAGCGCTCCCGAGAGGCAATCACAGGGTCGCGGCAATCTCGT

CRISPR arrays and Neighbor proteins around NZ_LS483441_7

CRISPR arrays

The CRISPR arrays of NZ_LS483441_7

>merge|NZ_LS483441|7|3170993-3171128|CRISPRCasFinder
CGGAGCCGGGGAAGAGGGCCGTTGTGGTCGCCCTCCCCTTGCCCTGGGGGATCACAGCGCTCCCGAGAGGCAATCACAGGGTCGCGGCAATCTCGTCGGAGCCGGGGAAGAGGACCGTTGTGGTCGCCCTCCCCTT

>NZ_LS483441|7|6|3170993-3171128|CRISPRCasFinder
CGGAGCCGGGGAAGAGGGCCGTTGTGGTCGCCCTCCCCTT	GCCCTGGGGGATCACAGCGCTCCCGAGAGGCAATCACAGGGTCGCGGCAATCTCGT
CGGAGCCGGGGAAGAGGACCGTTGTGGTCGCCCTCCCCTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LS483441.1|WP_010674088.1|3177920_3179459_+|inactive-transglutaminase-family-protein	unknown	unknown	gnl|CDD|379600
NZ_LS483441.1|WP_042017349.1|3169071_3170697_-|phosphoethanolamine--lipid-A-transferase	unknown	unknown	gnl|CDD|183224
NZ_LS483441.1|WP_039039848.1|3177128_3177917_+|ATP-dependent-zinc-protease	unknown	unknown	gnl|CDD|226553
NZ_LS483441.1|WP_029314241.1|3181747_3182197_+|peptidase-P60	unknown	unknown	gnl|CDD|236773
NZ_LS483441.1|WP_042017352.1|3175357_3176095_+|carboxy-S-adenosyl-L-methionine-synthase-CmoA	unknown	unknown	gnl|CDD|273244
NZ_LS483441.1|WP_010674094.1|3171140_3171881_-|YebC/PmpR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl|CDD|234640
NZ_LS483441.1|WP_042017348.1|3161240_3163904_-|family-20-glycosylhydrolase	unknown	unknown	gnl|CDD|119337
NZ_LS483441.1|WP_042017351.1|3174175_3175024_+|DUF72-domain-containing-protein	unknown	unknown	gnl|CDD|182366
NZ_LS483441.1|WP_010674096.1|3167713_3168928_+|ROK-family-protein	unknown	unknown	gnl|CDD|366120
NZ_LS483441.1|WP_010674101.1|3159236_3160898_-|glutamine--tRNA-ligase	unknown	unknown	gnl|CDD|235424
NZ_LS483441.1|WP_039039841.1|3164026_3165481_-|PTS-transporter-subunit-EIIC	unknown	unknown	gnl|CDD|273920
NZ_LS483441.1|WP_042017350.1|3171981_3173748_-|aspartate--tRNA-ligase	unknown	unknown	gnl|CDD|234775
NZ_LS483441.1|WP_039039849.1|3179462_3180428_+|alpha-L-glutamate-ligase-like-protein	unknown	unknown	gnl|CDD|274070
NZ_LS483441.1|WP_010674104.1|3157410_3157935_+|flavodoxin-FldA	unknown	unknown	gnl|CDD|236439
NZ_LS483441.1|WP_010674086.1|3180726_3181641_+|hydrogen-peroxide-inducible-genes-activator	unknown	unknown	gnl|CDD|176103
NZ_LS483441.1|WP_010674098.1|3165753_3166554_+|glucosamine-6-phosphate-deaminase	unknown	unknown	gnl|CDD|179028
NZ_LS483441.1|WP_010674102.1|3158708_3159137_+|ferric-iron-uptake-transcriptional-regulator	unknown	unknown	gnl|CDD|236527
NZ_LS483441.1|WP_042017353.1|3176098_3177076_+|tRNA-5-methoxyuridine(34)/uridine-5-oxyacetic-acid(34)-synthase-CmoB	unknown	unknown	gnl|CDD|237898
NZ_LS483441.1|WP_039039842.1|3166563_3167709_+|N-acetylglucosamine-6-phosphate-deacetylase	unknown	unknown	gnl|CDD|183010
NZ_LS483441.1|WP_010674103.1|3158003_3158477_-|DUF4442-domain-containing-protein	unknown	unknown	gnl|CDD|373120

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_LS483441.1|WP_010674088.1|3177920_3179459_+|inactive-transglutaminase-family-protein	gnl|CDD|379600	pfam14402, 7TM_transglut, 7 transmembrane helices usually fused to an inactive transglutaminase. A family of seven transmembrane helices fused to an inactive transglutaminase domain. The transglutaminase domain is predicted to be extracellularly located. Members of this family are associated in gene neighborhoods with a pepsin-like peptidase and an ATP-grasp of the RimK-family. The ATP-grasp is predicted to modify the 7TM protein or a cofactor that interacts with it.	2.42473e-152
NZ_LS483441.1|WP_042017349.1|3169071_3170697_-|phosphoethanolamine--lipid-A-transferase	gnl|CDD|183224	PRK11598, PRK11598, putative metal dependent hydrolase; Provisional.	0
NZ_LS483441.1|WP_039039848.1|3177128_3177917_+|ATP-dependent-zinc-protease	gnl|CDD|226553	COG4067, COG4067, Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones].	2.45546e-48
NZ_LS483441.1|WP_029314241.1|3181747_3182197_+|peptidase-P60	gnl|CDD|236773	PRK10838, spr, bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase.	3.29527e-42
NZ_LS483441.1|WP_042017352.1|3175357_3176095_+|carboxy-S-adenosyl-L-methionine-synthase-CmoA	gnl|CDD|273244	TIGR00740, tRNA_cmo5U34-methyltransferase, tRNA (cmo5U34)-methyltransferase. This tRNA methyltransferase is involved, together with cmoB, in preparing the uridine-5-oxyacetic acid (cmo5U) at position 34. [Unknown function, Enzymes of unknown specificity].	2.42375e-131
NZ_LS483441.1|WP_010674094.1|3171140_3171881_-|YebC/PmpR-family-DNA-binding-transcriptional-regulator	gnl|CDD|234640	PRK00110, PRK00110, YebC/PmpR family DNA-binding transcriptional regulator.	3.81824e-165
NZ_LS483441.1|WP_042017348.1|3161240_3163904_-|family-20-glycosylhydrolase	gnl|CDD|119337	cd06569, GH20_Sm-chitobiase-like, The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself.	0
NZ_LS483441.1|WP_042017351.1|3174175_3175024_+|DUF72-domain-containing-protein	gnl|CDD|182366	PRK10302, PRK10302, hypothetical protein; Provisional.	4.71716e-109
NZ_LS483441.1|WP_010674096.1|3167713_3168928_+|ROK-family-protein	gnl|CDD|366120	pfam00480, ROK, ROK family.	4.02053e-73
NZ_LS483441.1|WP_010674101.1|3159236_3160898_-|glutamine--tRNA-ligase	gnl|CDD|235424	PRK05347, PRK05347, glutaminyl-tRNA synthetase; Provisional.	0
NZ_LS483441.1|WP_039039841.1|3164026_3165481_-|PTS-transporter-subunit-EIIC	gnl|CDD|273920	TIGR01998, N-acetylglucosamine_and_glucose_PTS, PTS system, N-acetylglucosamine-specific IIBC component. This model represents the combined B and C domains of the PTS transport system enzyme II specific for N-acetylglucosamine transport. Many of the genes in this family also include an A domain as part of the same polypeptide and thus should be given the name "PTS system, N-acetylglucosamine-specific IIABC component". This family is most closely related to the glucose-specific PTS enzymes. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	0
NZ_LS483441.1|WP_042017350.1|3171981_3173748_-|aspartate--tRNA-ligase	gnl|CDD|234775	PRK00476, aspS, aspartyl-tRNA synthetase; Validated.	0
NZ_LS483441.1|WP_039039849.1|3179462_3180428_+|alpha-L-glutamate-ligase-like-protein	gnl|CDD|274070	TIGR02291, conserved_protein_of_unknown_function, alpha-L-glutamate ligase-related protein. Members of this protein family contain a region of homology to the RimK family of alpha-L-glutamate ligases (TIGR00768), various members of which modify the Glu-Glu C-terminus of ribosomal protein S6, or tetrahydromethanopterin, or a form of coenzyme F420 derivative. Members of this family are found so far in various Vibrio and Pseudomonas species and some other gamma and beta Proteobacteria. The function is unknown.	1.41338e-160
NZ_LS483441.1|WP_010674104.1|3157410_3157935_+|flavodoxin-FldA	gnl|CDD|236439	PRK09267, PRK09267, flavodoxin FldA; Validated.	5.30133e-106
NZ_LS483441.1|WP_010674086.1|3180726_3181641_+|hydrogen-peroxide-inducible-genes-activator	gnl|CDD|176103	cd08411, PBP2_OxyR, The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily. OxyR senses hydrogen peroxide and is activated through the formation of an intramolecular disulfide bond. The OxyR activation induces the transcription of genes necessary for the bacterial defense against oxidative stress. The OxyR of LysR-type transcriptional regulator family is composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The C-terminal domain also contains the redox-active cysteines that mediate the redox-dependent conformational switch. Thus, the interaction between the OxyR-tetramer and DNA is notably different between the oxidized and reduced forms. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.55377e-79
NZ_LS483441.1|WP_010674098.1|3165753_3166554_+|glucosamine-6-phosphate-deaminase	gnl|CDD|179028	PRK00443, nagB, glucosamine-6-phosphate deaminase; Provisional.	1.9275e-177
NZ_LS483441.1|WP_010674102.1|3158708_3159137_+|ferric-iron-uptake-transcriptional-regulator	gnl|CDD|236527	PRK09462, fur, ferric uptake regulator; Provisional.	2.84992e-104
NZ_LS483441.1|WP_042017353.1|3176098_3177076_+|tRNA-5-methoxyuridine(34)/uridine-5-oxyacetic-acid(34)-synthase-CmoB	gnl|CDD|237898	PRK15068, PRK15068, tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB.	0
NZ_LS483441.1|WP_039039842.1|3166563_3167709_+|N-acetylglucosamine-6-phosphate-deacetylase	gnl|CDD|183010	PRK11170, nagA, N-acetylglucosamine-6-phosphate deacetylase; Provisional.	0
NZ_LS483441.1|WP_010674103.1|3158003_3158477_-|DUF4442-domain-containing-protein	gnl|CDD|373120	pfam14539, DUF4442, Domain of unknown function (DUF4442). This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 139 and 165 amino acids in length. There is a conserved PYF sequence motif. There is a single completely conserved residue N that may be functionally important.	3.39755e-31

Protein sequences

>NZ_LS483441.1|WP_042017349.1|3169071_3170697_-|phosphoethanolamine--lipid-A-transferase
MRLTLGVMKVNLLLVLLFALVFNWPIFLHFYRILSALEHVKAGFVLSIPLVLVAALNAVFLPFTFRYLLKPFFALLIMTGSLVSYAMLKYGVIFDMGMMQNIIETNSGEAGSYLNGSVVLWFLLTGLLPVLVLLWVKIEYPRPWYKGLGLRLGSIALSLLFLMGAAALYYQDYASVGRNNKSLGKEIVPANYVHGLYKYARDVVFATPIPYQQIGTDARVIGQHEKPTLMFLVVGETARSQNYSLNGYTKETNGFTEKEANVVSFRNVRSCGTATALSVPCMFSNMTRRGYDEARAQSQDGLLDVLQHAGISVLWKENDGGCKGVCKNVPTIEIEPKAFPAYCSGNACHDEVLLQGLDQQIADMQGKQGSKLVAFHLMGSHGPTYYRRYPAADRVFLPDCPRSDIENCSNEELVNTYDNTIRYTDKVLAQLIDKLKSLESQYNVGLVYLSDHGESLGAMGLYLHGTPYKFAPDDQTRVPLLTWFSPQLQADRQLNLDCLQQEAASKRFSHDNLFHSMLGIMDVQTQVYDGKLDLFKPCRAG
>NZ_LS483441.1|WP_010674096.1|3167713_3168928_+|ROK-family-protein
MTGGQIANVDLIKQVNSAVVYRLIDLQGPISRVKIAELSQLAPASVTKITRQLIEHGLIRETSPQASTGGRRAISLTTIKHRFQFVSAKLGRGYLQLSLYDLDGKELDQHITQVTEIEQQPVVDMLLREIGAFIDANQDRSRNLISIALTMPGLVNPESGMVIYTPTYQIRNLGLAKLLEHHFNLPCYVGNDTRSLALAEHFFGESRDCMDSILVSVHQGTGSGIITKGKVFLGQNRNVGEIGHIQVEPLGKRCHCGNFGCLETIASNEAIVDKVKELISRGHLSSLQEKHITIQEVCKAAVAGDELARSVIENVGEHLGRAIAITVNLFNPQKVLIAGEITAAEEILIPAIRRCVEHQSLPSFHRGLPIVKARFQNQPTIGGFALVKRSLLEGDLLQIIMEQK
>NZ_LS483441.1|WP_039039842.1|3166563_3167709_+|N-acetylglucosamine-6-phosphate-deacetylase
MYALTNCTLYTGSCVLTGYGVVIDGDKIVAISRQAELPAGIEQIDLQGANLSAGFIDVQLNGCGGVMFNGHITTDTLATMQAANLKSGTTSFLPTLITSPDADMKQAVAVTRDYMAAHPNEVLGVHLEGPYTNLKRKGIHPAEQIRQPADEMIDFFCDNADAIAKITLAPERNKPEHIRRLVEAGILVSAGHTAANYDQAMAGFDNGMRFATHLYNAMTPTLNGREPGVVGAIYDRKDVYAGIIVDGHHVHWANVRLAHRMLGERLVLVTDATAAAGAPEGFEKFDFCGATVYFRDGQCVDENGTLGGSALTMIEGVENLVKQVGLPLDEALRMATLYPARAIGWDSRLGSIQVGKIANLTVFDQAFAVCGTVVNGHYTTQ
>NZ_LS483441.1|WP_010674098.1|3165753_3166554_+|glucosamine-6-phosphate-deaminase
MRLIPLKSASQVGLWSARYIVDRINAFKPTAERPFVLGLPTGGTPLNTYKRLIELHKAGEVSFQNVVTFNMDEYVGLPKEHPESYHSFMHNNFFNHVDIRPENINILNGNAEDLVAECQRYEDKIKSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRVKTLTEDTRIANSRFFGGDMEQVPKLALTVGVGTLMDAEEILILVVGHAKAQALQATVEGSVNHMWTISTLQLHPKGIVVCDEPSTMELKVKTVRYFQQLEADNIKHL
>NZ_LS483441.1|WP_039039841.1|3164026_3165481_-|PTS-transporter-subunit-EIIC
MNILGYLQKIGRALMVPVAVLPAAAILMGIGYWIDPNGWGGGSPLAAFLIKAGAAIIDSMPILFAVGVAYGMSKDKDGSAALAGLVGFLVVTTLLSPGAVAQIKGIPADQVPAAFAKISNQFVGILCGVIAAELYNRFSSVELHKALAFFSGRRLVPIVTSVVMIVVSFILMAVWPVIYGGLVSFGESIVSMGSTGAGIYAFFNRLLIPVGLHHALNSVFWFDVAGINDIPNFLGGQSSIDAGKAVVGVTGMYQAGFFPIMMFGLPGAALAIYHSAKKENKEKVASIMIAAAFAAFFTGVTEPLEFSFMFVAPVLYVIHALLTGISVFIAASMHWIAGFGFSAGLVDMVLSSRNPLATQWYMLLVQGLVFFGLYYVVFRAVIAKFNLKTPGREDDEAVPVQAQTTDRTELAKQYLEVLGGQENLVTIDACITRLRLTLKDRSIVDERKLKALGAAGVVKLGEQNLQVILGPLAEIIAGEMKALR
>NZ_LS483441.1|WP_042017348.1|3161240_3163904_-|family-20-glycosylhydrolase
MNLKHSLLAIAMSTVFAGPALAADAARQAVVDALASNLVVKYEVVTNDGAGAGLDCQALGSEWASCGVAKLHLTNTGADVTSKDWSIYVSSIRRIQRVDNDQFTITHLTGDLYRLTPTEKFQGFAKDATVEVPLVVEYWVLFESDIMPNWYVASEGAEPKVLASMSNIDDASTYEKPMPADGWKRTKDDNNILMNSETRFAANQTSTLLPAGKIDDRILPSPMKQVVKAGPQIDFSTIKLNALDLPSDRAEALKAQLTKLGVTLSDTGYPVTIKLGSKLKQAEGYDMTIGKKGTVIQGHDVDGAFWGAQSLISLLGVDDKLVSQMSVEDAPRFEYRGMQTDVARHFRSPETMKKLVDQMSAMKLNVLHLGLTNDEGWRLEIPGLPELTDVGSQRCHDESETKCLMPQLGSGPTSDNQGSGFYSKTDYIDLVRYAKARGVTVIPEINMPAHARAAVVSMEARYKRLMSEGKEAEANQFRLTDPADTSNVTSVQFYDKMSFINPCQPGAATFVAKVMDEVAQMHQAAGQPLTAWHYGGDEAKNIMQGGGYQDPAVTKKEDLVAWKGNVDSSKQDKPFGKSPMCQKMIDDGKIKDVAELPVYFAKEVSEMVKGHGFSTLQAWEDGLKYATDASVFATDKTRVNFWETLYWGGFNEAMKWAHKGYDVVLSNPDYLYFDFPNEVHPAERGYYWATRFNDTRKVFAFAPENLPQNAETSVDRDGNAFVAKGDQDPVKFKGISGQQWSETVRTDAQYEYMVYPRIFSVAERAWHKGGFELDYVKGREFSGTTKHVNKATLNKEWNQFANVLGQRVLPKLDQAGVEYRLSVPGAKVVNGVLEANVDLPGLPIQYSLDGKSWSAYDAAAKPTVDGKVYLRTTSFDGKRTSRVTELN
>NZ_LS483441.1|WP_010674101.1|3159236_3160898_-|glutamine--tRNA-ligase
MSQANSPTNFIRQIIDEDLASGKHSSVHTRFPPEPNGYLHIGHAKSICLNFGIARDYQGQCNLRFDDTNPAKEDIEFVESIKQDVQWLGFQWSGEICYSSDYFHKLHGYAIELIEKGLAYVDELSPEQMREYRGTLTAPGKNSPFRDRSVEENLALFAKMKNGEMAEGSACLRAKIDMASPFMVMRDPVIYRIKFAHHHQTGDEWCIYPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNISIDCHPRQYEFSRLNLEYTVMSKRKLNLLVTEGHVNGWDDPRMLTVSGLRRRGYTPASIREFCKRIGVTKQDNIVEMSMLEACIRDDLNENAPRAMAVLHPVKVVIENLAADEVLTAPAHPNKPEMGTRELHFSREIFIDEADFKEEANKQFKRLVLGKEVRLRNAYVIKAERVEKDADGKVTCIYCSYDPETLGKDPADGRKVKGVIHWVSATHSLPAEVRLYDRLFKVPNPGAEDDFEAALNPESLVIIEGARVEASLKDAKPEFAYQFEREGYFCADNKLSSAERLVFNRTVALRDVWGKAEA
>NZ_LS483441.1|WP_010674102.1|3158708_3159137_+|ferric-iron-uptake-transcriptional-regulator
MADNNQALKKAGLKITLPRVKILEILQQPDCQHTSAEDLYKRLIDQGEEIGLATVYRVLNQFDDAGIVTRHHFEGGKSVFELATQEHHDHLVCLDCGKVIEFSDEVIEQRQRDIAKAHNIRLTNHSLYLYGHCANGDCKHDD
>NZ_LS483441.1|WP_010674103.1|3158003_3158477_-|DUF4442-domain-containing-protein
MDWLFGNAAWVRCALNAWPPFWGAGIKIETLSPDFRFCRVTLKSRWWNKNANRTQFGGSMFAMTDPIYPLMLMGYFKNRYYVWDKAGSINFIKPGKGKLVAEFTLSDAKLASIVAATEGGEKHFPEFEVQVQDGQGELVAQVKRTLYVRSKPQHRGG
>NZ_LS483441.1|WP_010674104.1|3157410_3157935_+|flavodoxin-FldA
MASVGLFFGSDTGNTEAVAKMIQKELGKQLIEVRDIAKSSKADIDSFDLLMFGIPTWYYGEAQADWDDFFPELEEIDFNNKLVAIFGCGDQEDYAEYFLDAMGTLRDIVEAKGAIIIGHWPTASYEFEASKALVDDKHFVGLGIDEDRQPELTAERVKGWCKQLHEEMCLGELE
>NZ_LS483441.1|WP_010674094.1|3171140_3171881_-|YebC/PmpR-family-DNA-binding-transcriptional-regulator
MAGHSKWANIKHRKAAQDAKRGKIFTKLIREITTSARLGDADPANNPRLRAAVAAALTSNMTRDTINRAIARGAGGGDGEQLETIVYEGYGPAGSAVMVECLTDNRNRTVAEVRHAFSKCGGNLGTDGSVAYLFTKKGVLTFVGADEDALMDAALEAGADDVVTEEDGTIEVYTTPNDFGTVLDGLEAAGFKPESAEVTMIPSTEAELDAETAPKLMRLIDMLEDLDDVQEVYHNGSISDEIAATL
>NZ_LS483441.1|WP_042017350.1|3171981_3173748_-|aspartate--tRNA-ligase
MRSIYCGQVNEAHAGQTITLCGWVHRRRDLGGLIFIDMRDREGIVQVFFDPDKPDAFALASELRGEFCIQVTGVVRTRPDSQRNSDMATGAIEVFAHELTIINRAEPLPLDFNQVNSEEVSLKYRYLDLRRPEMAKYLKTRAKASAFVRRFMDEHGFLDIETPMLTKATPEGARDYLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFMTAPQVREIMEEMIRKLWLHILNVDLGDFPIMTFDEAMRRFGSDKPDLRLPMELVDLADLLTEVEFAVFAGPAKDPKGRVAALKVPGGAELSRKQIDEYTKFVGIYGAKGLAWMKVNDAGSGIEGVQSPVAKFLSDAIVREILARTGAMDGDIIFFGADSKKVVCDAMGALRLKVGRDLGLVENVWKPLWVIDFPMFEEDGEGGLAAMHHPFTAPSNLGPAELKANPVGAYANAYDMVINGYEVGGGSVRIHNSEMQSTVFDILGITPDEQRLKFGFLLDALKYGTPPHAGLAFGLDRLSMLLTGTDNIRDVIAFPKTTAAACLMTDAPSFANPAQLGELAIATTVKGDE
>NZ_LS483441.1|WP_042017351.1|3174175_3175024_+|DUF72-domain-containing-protein
MSLYLGLPQWSHPAWPGQLLGMNARPAEHLADYARVFNSVEGNTTFYASPTPETVQRWADAVPDHFRFSFKFPKEISHQSDLVSVDKQVTAFIRLLAPLHGKLGLLKLQLPARFGPEGLARLDAFFARLPQDFTYALEVRHPDFFAKGEAERALNRMLMARGINRIMLDSRPLFSVPATTAAMIDAQGKKPRLPVHLLATGGAPVVRLIGLPQIEDNHPFLPPWLPHWKQWLQEGKDLYLFVHTADNARAPELARQISRLLGQEMAPWPGENDRARQGVLPF
>NZ_LS483441.1|WP_042017352.1|3175357_3176095_+|carboxy-S-adenosyl-L-methionine-synthase-CmoA
MHDQIFAAPIARLGDFCFDEQVVDVFPDMIQRSVPGYSNIISAIGMMAARYAQPQSRLYDLGCSLGAATQAMRRHVTQPGCQITAVDLSHPMIERARAHLSGFKSEVPVELIEADICDIPIENASVVVLNFTLQFVAPEKRAALIARIFDGLRPGGILILSEKFRFDDEQVNELLIDLHLDFKRANGYSELEISQKRTALENVMRTDTLAVHQARLRDAGFTHLDLWFQCFNFGSMIAIKASDTN
>NZ_LS483441.1|WP_042017353.1|3176098_3177076_+|tRNA-5-methoxyuridine(34)/uridine-5-oxyacetic-acid(34)-synthase-CmoB
MIDFAHFYQLIAKNRLSHWLHTLPAQLHAWQHDNLHGDLPRWNRALAKLPVVAPGRIELKERVAIGGSDSLGEGERKKTESLLRQLMPWRKGPFHVHGIHIDTEWRSDWKWDRVLPHISPLQGRYVLDVGCGSGYHLWRMVGEGAKLAVGIDPSPLFLCQFEAIRHFMDNDQRAHLLPLGIQELPALRAFDTVFSMGVLYHRKSPIEHIEQLRNQLKDDGELVLETLVVDGDENQVLMPSDRYGKMRNVWFLPSSAALTRWVERCGFTDVRIVDENMTSTDEQRRTDWMINESLSDYLDPHNPALTVEGYPAPKRAVLIARKAKD
>NZ_LS483441.1|WP_039039848.1|3177128_3177917_+|ATP-dependent-zinc-protease
MNDMKSKLKGMTLLSLLSLGGCVSMEKAPPAPTLTLAELRNEISLSEQRLQTSMEQQQKQYVQQQHLLVQLNTDVTNMKESVKKVDSKLATLPPEPPKAMPIPTEKCPAPSQGHTVDGKLLVGEAEWIWVDAANDAFQARVDTGATTSSISAQEITIFERNGKNWVRFFLSHQEMDDKIQIEAPLVRHVRVRQASADDLDRRPVVRLAVRIGDMTEKAEFTLKDRSDMTFPVLLGREFLKDIAVVDVAREYIQPKPKLKDVK
>NZ_LS483441.1|WP_010674088.1|3177920_3179459_+|inactive-transglutaminase-family-protein
MVSRKPFYLLVALLYIVGLGMTFYHHIALDVPLTPGEKRQIWSIEAKLEFEATGEPVIASLAIPGTQPGFTLMNENAASPGYGLSFVEKDGDARAEWSIRTASGRQELYYRVDMMADAHAKPAANPQPPAIEKQIESEPYATAMKQILERAQERSADGYTLTREIIKEIEKQEQNAELLKSHKSRANLIAELLNNADVPARVVHALSLEDGRRRQELVDYLQVFNSPTDYKLFNPQSGEQGQPANLLLWEYNSGALLDVTGGHNSRVTFSMIEQEQPVNVALAQKFEKSEMMNFSIHSLPLEEQALFKGLLLIPIGVLMVVFLRVIVGIKTSGTFMPVLIAVAFIQTSLVTGLIGFLLIVGTGLVIRSYLSRLNLLLVARISAIIIMVISMIGIFSAFAFKLGLTDGMKITFFPMIILSWTIERMSILWEEEGPKEVFRQGGGSLLVAVIAYLAMDNELIRHLTFNFLGLQLVLMATVLLMGNYTGYKLSELKRFKPLVDEMKSGATPGKDK
>NZ_LS483441.1|WP_039039849.1|3179462_3180428_+|alpha-L-glutamate-ligase-like-protein
MWFWQKYTSPWSLSQAGILGMNKRNHSYISRYNPRRLYPLVDDKLKTKRIALDAGVTVPELIGTIREQHDVTRITELVKDWPGFCIKPARGSGGKGILVILRQEDGLFYKPNGSAANGQDLERHVSNILAGLYSLGGKPDVALVEGLINFDDVFDGYSFEGVPDARVIIFKGFPVMAMMRLSTSASDGKANLHQGAVGVGLCLRTGRALRAVQFGNPLRHHPDTGLDLYDLKVPHWDTLLNLAASCYEMSGLGYIGTDMVLDKFRGPMLLELNARPGLAIQIANGRGLVPNLKTIEKLGQVKMNVEQRVNFAKDHFGIFDE
>NZ_LS483441.1|WP_010674086.1|3180726_3181641_+|hydrogen-peroxide-inducible-genes-activator
MQRWPSLKQLQYLVALDEHKNFNRAAKACHVSQSTLSTGIQTLEDMMNLQLVERDHKSFIMTPVGMEIVARARNLLSDARDLMELGQQQGGVMHGTVRLGCIPTIAPFLLSKLLQVCGKAYPDLELLLREDTTTNLLKQLEQGQLDLLILALPVEIGGFHSKTVGQDPFHMVMPSHMAAGLHMPFDYKELPNQSIFLLEREHCLTEHAVSACRLRDKSKINPFAATSLHTLVQMVGAGLGTTFLPQMAIDAGILDNTDLVAIPLPGEKPYREIGLVWRPSTTRVQTFYKIAELLTPLITPKPAG
>NZ_LS483441.1|WP_029314241.1|3181747_3182197_+|peptidase-P60
MFRTLLLPLLALLLAACSSTPEPPPPVRQSGAFDNFYQQWRGVPYRMGGTSRAGLDCSAFTQLAYSQVLGFTLPRTTESQASLGRPVDRYRLQHGDLVFFKTGWQQYHVGVYTGAGEFIHASTSKGVIRSRLDNVYWNSRYWQARRLVQ

Crispr_ID: NZ_LS483441_8

• CRISPR_ID: NZ_LS483441_8
• CRISPR_location: 3527282-3527392
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_LS483441_8

Consensus_repeat	Method
GGGTCTGTAATGGCTTGAGGCCCGACCCATTGAGCA	CRISPRCasFinder

spacers of NZ_LS483441_8

>8.1|3527318|39|NZ_LS483441|CRISPRCasFinder
AGGTGGCCGCATGAGCAGCCACTACCTGCACAAGAAGCC

CRISPR arrays and Neighbor proteins around NZ_LS483441_8

CRISPR arrays

The CRISPR arrays of NZ_LS483441_8

>merge|NZ_LS483441|8|3527282-3527392|CRISPRCasFinder
GGGTCTGTAATGGCTTGAGGCCCGACCCATTGAGCAAGGTGGCCGCATGAGCAGCCACTACCTGCACAAGAAGCCGGGTCTGTAATGGCTTGAGGCCCGGCCCATTGAGCA

>NZ_LS483441|8|7|3527282-3527392|CRISPRCasFinder
GGGTCTGTAATGGCTTGAGGCCCGACCCATTGAGCA	AGGTGGCCGCATGAGCAGCCACTACCTGCACAAGAAGCC
GGGTCTGTAATGGCTTGAGGCCCGGCCCATTGAGCA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LS483441.1|WP_010675395.1|3516504_3516954_-|transcriptional-regulator-NrdR	unknown	unknown	gnl|CDD|234774
NZ_LS483441.1|WP_042014451.1|3531739_3532756_+|zinc-binding-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|176214
NZ_LS483441.1|WP_039040307.1|3524987_3525437_+|type-II-3-dehydroquinate-dehydratase	unknown	unknown	gnl|CDD|235443
NZ_LS483441.1|WP_167418749.1|3517088_3517511_-|hypothetical-protein	unknown	unknown	unknown
NZ_LS483441.1|WP_042014455.1|3529341_3530766_+|PTS-transporter-subunit-EIIC	unknown	unknown	gnl|CDD|273920
NZ_LS483441.1|WP_042014459.1|3520794_3522582_+|GGDEF-and-EAL-domain-containing-protein	unknown	unknown	gnl|CDD|236645
NZ_LS483441.1|WP_042014450.1|3533286_3534165_+|50S-ribosomal-protein-L11-methyltransferase	unknown	unknown	gnl|CDD|283886
NZ_LS483441.1|WP_042014461.1|3520319_3520688_+|hypothetical-protein	unknown	unknown	unknown
NZ_LS483441.1|WP_042014449.1|3534593_3535142_+|sugar-O-acetyltransferase	unknown	unknown	gnl|CDD|100047
NZ_LS483441.1|WP_010675416.1|3536780_3537329_-|NAD(P)H-nitroreductase	unknown	unknown	gnl|CDD|182761
NZ_LS483441.1|WP_042014456.1|3527796_3529254_+|sodium/pantothenate-symporter	unknown	unknown	gnl|CDD|236519
NZ_LS483441.1|WP_039040309.1|3527558_3527807_+|YhdT-family-protein	unknown	unknown	gnl|CDD|377626
NZ_LS483441.1|WP_042014552.1|3537436_3539464_-|NADPH-dependent-2,4-dienoyl-CoA-reductase	unknown	unknown	gnl|CDD|239240
NZ_LS483441.1|WP_010675405.1|3525473_3525935_+|acetyl-CoA-carboxylase-biotin-carboxyl-carrier-protein	unknown	unknown	gnl|CDD|235777
NZ_LS483441.1|WP_041215688.1|3535162_3536242_-|chemotaxis-protein	unknown	unknown	gnl|CDD|206779
NZ_LS483441.1|WP_010675399.1|3519205_3519493_+|hypothetical-protein	unknown	unknown	unknown
NZ_LS483441.1|WP_010675397.1|3517610_3518864_-|serine-hydroxymethyltransferase	unknown	unknown	gnl|CDD|234571
NZ_LS483441.1|WP_042014452.1|3530766_3531639_-|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|176114
NZ_LS483441.1|WP_042014462.1|3519643_3520312_+|molecular-chaperone-TorD	unknown	unknown	gnl|CDD|235326
NZ_LS483441.1|WP_042014457.1|3522757_3524704_+|acetate--CoA-ligase	unknown	unknown	gnl|CDD|234677

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_LS483441.1|WP_010675395.1|3516504_3516954_-|transcriptional-regulator-NrdR	gnl|CDD|234774	PRK00464, nrdR, transcriptional repressor NrdR.	3.18874e-93
NZ_LS483441.1|WP_042014451.1|3531739_3532756_+|zinc-binding-alcohol-dehydrogenase-family-protein	gnl|CDD|176214	cd08252, AL_MDR, Arginate lyase and other MDR family members. This group contains a structure identified as an arginate lyase. Other members are identified quinone reductases, alginate lyases, and other proteins related to the zinc-dependent dehydrogenases/reductases. QOR catalyzes the conversion of a quinone and NAD(P)H to a hydroquinone and NAD(P+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	0
NZ_LS483441.1|WP_010675397.1|3517610_3518864_-|serine-hydroxymethyltransferase	gnl|CDD|234571	PRK00011, glyA, serine hydroxymethyltransferase; Reviewed.	0
NZ_LS483441.1|WP_042014459.1|3520794_3522582_+|GGDEF-and-EAL-domain-containing-protein	gnl|CDD|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	7.14815e-113
NZ_LS483441.1|WP_042014450.1|3533286_3534165_+|50S-ribosomal-protein-L11-methyltransferase	gnl|CDD|283886	pfam06325, PrmA, Ribosomal protein L11 methyltransferase (PrmA). This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.	1.03512e-141
NZ_LS483441.1|WP_042014449.1|3534593_3535142_+|sugar-O-acetyltransferase	gnl|CDD|100047	cd03357, LbH_MAT_GAT, Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6 position of the nonreducing end glucosyl moiety. GAT specifically acetylates galactopyranosides. Furthermore, MAT shows higher affinity toward artificial substrates containing an alkyl or hydrophobic chain as well as a glucosyl unit. Active MAT and GAT are homotrimers, with each subunit consisting of an N-terminal alpha-helical region and a C-terminal left-handed parallel alpha-helix (LbH) subdomain with 6 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X).	3.25913e-90
NZ_LS483441.1|WP_010675416.1|3536780_3537329_-|NAD(P)H-nitroreductase	gnl|CDD|182761	PRK10828, PRK10828, putative oxidoreductase; Provisional.	4.03498e-84
NZ_LS483441.1|WP_042014456.1|3527796_3529254_+|sodium/pantothenate-symporter	gnl|CDD|236519	PRK09442, panF, sodium/pantothenate symporter.	0
NZ_LS483441.1|WP_039040309.1|3527558_3527807_+|YhdT-family-protein	gnl|CDD|377626	pfam06196, DUF997, Protein of unknown function (DUF997). Family of predicted bacterial membrane protein with unknown function.	7.21087e-19
NZ_LS483441.1|WP_042014552.1|3537436_3539464_-|NADPH-dependent-2,4-dienoyl-CoA-reductase	gnl|CDD|239240	cd02930, DCR_FMN, 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the flavin and iron-sulfur cofactors. Metabolism of unsaturated fatty acids requires auxiliary enzymes in addition to those used in b-oxidation. After a given number of cycles through the b-oxidation pathway, those unsaturated fatty acyl-CoAs with double bonds at even-numbered carbon positions contain 2-trans, 4-cis double bonds that can not be modified by enoyl-CoA hydratase. DCR utilizes NADPH to remove the C4-C5 double bond. DCR can catalyze the reduction of both natural fatty acids with cis double bonds, as well as substrates containing trans double bonds. The reaction is initiated by hybrid transfer from NADPH to FAD, which in turn transfers electrons, one at a time, to FMN via the 4Fe-4S cluster. The fully reduced FMN provides a hydrid ion to the C5 atom of substrate, and Tyr and His are proposed to form a catalytic dyad that protonates the C4 atom of the substrate and completes the reaction.	0
NZ_LS483441.1|WP_010675405.1|3525473_3525935_+|acetyl-CoA-carboxylase-biotin-carboxyl-carrier-protein	gnl|CDD|235777	PRK06302, PRK06302, acetyl-CoA carboxylase biotin carboxyl carrier protein.	3.66265e-78
NZ_LS483441.1|WP_041215688.1|3535162_3536242_-|chemotaxis-protein	gnl|CDD|206779	cd11386, MCP_signal, Methyl-accepting chemotaxis protein (MCP), signaling domain. Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.	2.74907e-30
NZ_LS483441.1|WP_039040307.1|3524987_3525437_+|type-II-3-dehydroquinate-dehydratase	gnl|CDD|235443	PRK05395, PRK05395, type II 3-dehydroquinate dehydratase.	1.44095e-97
NZ_LS483441.1|WP_042014455.1|3529341_3530766_+|PTS-transporter-subunit-EIIC	gnl|CDD|273920	TIGR01998, N-acetylglucosamine_and_glucose_PTS, PTS system, N-acetylglucosamine-specific IIBC component. This model represents the combined B and C domains of the PTS transport system enzyme II specific for N-acetylglucosamine transport. Many of the genes in this family also include an A domain as part of the same polypeptide and thus should be given the name "PTS system, N-acetylglucosamine-specific IIABC component". This family is most closely related to the glucose-specific PTS enzymes. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	6.75159e-94
NZ_LS483441.1|WP_042014452.1|3530766_3531639_-|LysR-family-transcriptional-regulator	gnl|CDD|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.79703e-71
NZ_LS483441.1|WP_042014462.1|3519643_3520312_+|molecular-chaperone-TorD	gnl|CDD|235326	PRK04976, torD, chaperone protein TorD; Validated.	2.25668e-54
NZ_LS483441.1|WP_042014457.1|3522757_3524704_+|acetate--CoA-ligase	gnl|CDD|234677	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional.	0

Protein sequences

>NZ_LS483441.1|WP_010675405.1|3525473_3525935_+|acetyl-CoA-carboxylase-biotin-carboxyl-carrier-protein
MDIRKIKKLIELVEESGIAELEISEGEESVRISRNFSGQVSVAPQMIMPQAAAQVAAPVAAAPAAAAAPAADAAPSGHLMRSPMVGSFYRSSSPEAKPFVEVGQHVNVGDTLCIVEAMKMMNQIESDKAGVIKAILVENGQAVEFDEPLFIIE
>NZ_LS483441.1|WP_039040307.1|3524987_3525437_+|type-II-3-dehydroquinate-dehydratase
MSQHHRILLLNGPNLNLLGKREPGIYGSKTLDEIVADLTRSASELGVTLEHLQSNAEHELIGRIHQAMGQVDFIIINPAAFTHTSVALRDALLGVAIPFIEVHLSNVHAREPFRHHSYLSDVAKGVICGLGADGYQFALTAAVHQLRAA
>NZ_LS483441.1|WP_042014457.1|3522757_3524704_+|acetate--CoA-ligase
MSESKVYPVKAHIGNGALLDKEGYEAMYQASVQDPDAFWGEQGKILDWMTPYTRVKNTSYDPGHVSIKWYEDGLLNVSANCLDRHLSERGDKVAIIWEGDNPAEDRKITYRELHAEVCKFANVLKAQGVKRGHMVCLYMPMVPEAAIAMLACTRIGAVHSIVFGGFSPEALSGRIIDSGASVVITADEGLRGGRPIPLKKNVDEALTHTDTKVSKVIVLKRTGGNVAWHDHRDIWWHDAVNAASPDCPPEAMGAEDPLFVLYTSGSTGKPKGVLHTTGGYLVYAALTFKYVFDYHEEDIYWCTADVGWVTGHSYLVYGPLANGATTVMFEGVPNYPATNRMSQVVDKHQVTILYTAPTAIRALMAKGKEAVEGTSRTSLRIMGSVGEPINPEAWEWYYRTIGDERCPIVDTWWQTETGGILITPLPGVTALKPGSATRPFFGVQPALVDNLGEPLEGATEGNLVITDSWPGQMRTVFGDHERFEQTYFSTFPGRYFTGDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEIESALVAHPKIAEAAVVGVPHEIKGQGIYAYVTLIAGEEPSRELHKEVKEWVRKEIGAIATPDVIHWAEGLPKTRSGKIMRRILRKIATGETDSLGDISTLADPGVVDKLIREKSEAA
>NZ_LS483441.1|WP_042014459.1|3520794_3522582_+|GGDEF-and-EAL-domain-containing-protein
MEKVLPESVPTRHLSGPLSPYELQQLFAQAPVGIGVFDHEFRCRDVNGRFAELTGLARAEHPGKTLFDIVPAQTPQLLPLFQQLRQGAPRCAFEVETVGLSRAASPARWQVSVSSVLDEEGTFSGIFLVMRESVQTSTHLDAPASPGLQEMTHLHALRLYQAEARLQHLSYYDPLTDLGNRHLLQERLTLEIETARVNRHVLALLFIDLDGFKLINDNLGQSAGDLLLKLSADRIRHCLRPGDIAIRLGADEFLVLLPAIRDTQDLLGLIEGLQRRLHDPADIGQERVRLSASIGISLYPEHGQTPDSLISAADNAMHEAKRRGRNGYLFHSPDMTAQTRERMLLEQGLLKAIEQQEFRLLYQPMTDLADGHLSGLEALIRWQHPSLGMISPDRFIPVAEECGLIEPLGEWVMRTACRQGQQWLAEGLAVPRLSVNVSVREMRSHDYVERVTAILAETGFPAERLEIEVTESIIQSVDHSLRLFTRLKALGVQIAIDDFGTGFSSLSLLRSLPIDRIKIDRAFVQALPDDKHSRELCRTIVQLASSLGMAVTAEGIETQPQRQFLQSLRCEEGQGYLFSHPLPEPSLPPLLPLRH
>NZ_LS483441.1|WP_042014461.1|3520319_3520688_+|hypothetical-protein
MKTALLLIACWLLALIPLDQGLTPLVTLLFNPDRALYGTAQLTGFAGILLTLYLANLGVEVVLRRRFQIAGMLALLAAWADFINSSGTESHWLVLYAMALPFHLVGWLVFVRGIQAFGRQKG
>NZ_LS483441.1|WP_042014462.1|3519643_3520312_+|molecular-chaperone-TorD
MQEFMATSERRAELYWWFSTLFAAELSDAQIAEYDTYDVRSFLKSLSTLDPMREAVAELNDAIARLLVRPERQTALAADFASLFLSAPGQGALPYESLYRGEGKQLMQAPMTEMQARLDRLGINVSDKYNEPADHLAIELDLMGSLIIRAAEATTADQREAWLGEQESLLHGHLLGWFERFEQACRAADTFGFYGASARLLGVFLKMDANYLSLVKPAPSAD
>NZ_LS483441.1|WP_010675399.1|3519205_3519493_+|hypothetical-protein
MMDHLMLFVIVAVFALFYWVYYTASRKGACTANWETLPTREQYLAAHPGAADGDLIFCIHCGHHQQREVGLVHQMDYRRQHICPRCKQVLYRVEE
>NZ_LS483441.1|WP_010675397.1|3517610_3518864_-|serine-hydroxymethyltransferase
MLKRDMTIAGYDPELWQAITDETRRQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYPAKRYYGGCEYVDVVETLAIERAKELFGATYANVQPHSGSQANSAVYMALLQPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIIPYGIDESGKIDYDEMERLAVEHKPKMMIGGFSAYSGIVDWARMREIADKIGAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTSTTHKTLAGPRGGLILSAADDEDLYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEALEPEFKTYQAQVVKNAKAMAATFIERGYKIVSGGTDNHLMLVDLIGRELTGKDADAALGKANITVNKNSVPNDPRSPFVTSGVRIGTPAITRRGFKEAESIQLANWICDVLDSHDNEEVLATVREKVLDICRRFPVYA
>NZ_LS483441.1|WP_167418749.1|3517088_3517511_-|hypothetical-protein
MKEDVLEASLRQTVRAQYHFRASEQGLLAWDVRRLIRLSRNLPVQAVALGEIAELDRNHWYGHGDATPTVRSVVAHCQLMMAADLAYPILLDSAGRVMDGMHRVGKALMLGHSHIEARRFAVDPAPDYQDCDPEALPYDD
>NZ_LS483441.1|WP_010675395.1|3516504_3516954_-|transcriptional-regulator-NrdR
MHCPFCSAVDTKVIDSRLVAEGHQVRRRRECLLCHERFTTFEMAELVMPRVIKSNGSREPFNEDKLRAGILRALEKRPVSMEAIEKAVNHIKSRLRATGEREVASQLVGNLVMDELKSLDKVAYIRFASVYRSFEDIREFGEEIAKLEK
>NZ_LS483441.1|WP_039040309.1|3527558_3527807_+|YhdT-family-protein
MNRFALARREAAFCLLLTLLYFVAWYGSAYFIPEDLELWDLPLWFLLSCILMPLLFIGLCALMVDRLFVDIPLDSEVPPHES
>NZ_LS483441.1|WP_042014456.1|3527796_3529254_+|sodium/pantothenate-symporter
MNLELMLPLCIYLVLVLGVGFWASRHRTGGNFMQEYFIGNRSMGGLVLAMTLVATYTSASSFIGGPGAAYKVGLGWVLLAMIQLPTVWLTLGVLGKKFAIIARRVNAVTINDMLWARYQSRAVVVLGSVTIILAFIATMVVQFIGGARLLETATGLSYQQGLFLFASCVLLYTVIGGFRAVVMTDALQGIVMLIGTGALLAGILIAGDGLPNLVHQLKEIDPKLVSPQGAGDMLTQPFMLSFWVLVCIGVVGLPHSALRCFGYRDSKALHRGILIGTIVCALLMFGMHLAGALGRAILPGMDSPDKIMPSLMMEVLPPWLAGVFLAAPMAAIMSTIDSQLIQASATLVKDLYLNYLNPRQEKLEVRVPRLSLLCTLILGTLVLLAALQPPEMIIWLNLLAFGGLQAVFLWPLVLGLYWSRANGPGALASMVCGILCYGTLSQWGIKVAGLHAIVPSLALGLAAFVLVSLLTPAPDQRVRRLFDQN
>NZ_LS483441.1|WP_042014455.1|3529341_3530766_+|PTS-transporter-subunit-EIIC
MPVQNARKILTQSLLRLGYALLLPVSILPLAALLHRLGQPDVLDLAVLSLAGRALFSQMPLIYAVAIAFGLSRQGQGAQALAGAVNFLLLSSALGTLVPGLHADMICGLLAGLVTAMVCSRARALRLPGWLRPLQEDLPGMLLSALACLLLVIPLSILWPLLEQGLTLLASDLLTTPFGAFCYGVLNRLLIPLGLHQVLGSLIGLGESNQQALSTAQPLHEGYVAGLYPVIMFGLPGACFAIWIHRQRMQQLPQGGLLLTLALTSALVGITEPIEFLFAFTAPWLFLAHALLTGLSLAICSGLDIQVGSYFSAGLLDLVLSYHAGLHSFWLIPLGILFFVVYTLLFSRLLEHAPLSLPGKPITEDLSRLATVAPTDPQMLAIQYLKMLGGMDNLQAMSVCLTRLSLRVRDMALVDQSCLARLGCLSWIVLNEHQLVLVLGPHAGLIEGQIRMLAERQSVPLGLEPAQAPLGQHQ
>NZ_LS483441.1|WP_042014452.1|3530766_3531639_-|LysR-family-transcriptional-regulator
MNNVELELMGLFATVVEQGSFTGAAEVLGMPKSSVSQKISRLESRLGVRLLQRTTRRLSLTPQGEVYVAHCQELLALARSANLAMARLRAAPGGRVRITAPEATGTLLLGRILAEFRALYPEVVLELTLCDEQLDLVGEGYDLALRAAPLKDSSLICRRIGQVARHLVASPGYLAANGTPLQLSELAGHACLVHGSLPVWPLQEGGWRPRGACQSNSLLALRELALHDGGIALLPAHVCGDDLAAGRLLKVLPDLLVPVNPFYLIYPSREHLAPALRSLMDFVAERLPFA
>NZ_LS483441.1|WP_042014451.1|3531739_3532756_+|zinc-binding-alcohol-dehydrogenase-family-protein
MKAIALTHYLPSNHPHCFIESDLPDPTPGPRDLLVRVNATSINPVDTKVRAPKDKVESSPRVLGWDAVGEVIAVGSDVTLFKAGDRVWYAGDISRPGSNSALQLVDERIAAIAPVTLTDLEAAALPLTAITAWETLFERMSLTRESTGRLLIIGGAGGVGSIAIQLARQLTDMEVIATASRPETREWCLDMGAHQVVSHHHLQAELKALGISEVDAIFCTNATEQHWNTMASLIRPFGHICTIAESSEPWDLGLLKPKSVTFSQEFMFTRSLFQTPDMIEQHNLLGRVAALIDEGVLKTTLSKVVPELTPLTLARAHAELEAGRMVGKLVIDMSGFHR
>NZ_LS483441.1|WP_042014450.1|3533286_3534165_+|50S-ribosomal-protein-L11-methyltransferase
MPWIQIRINATAKTADKVSNMLLGRGAQAVTFMDAKDVPVYEPMPGETPLWGETEVMGLFDAETDPAPTIAFFQQIFGKDVGYKVEQLEDKDWVREWMDHFHPMQFGERLWICPSWRDVPNPDAVNVMLDPGLAFGTGTHPTTALCLQWLDGLDLAGKTVVDFGCGSGILGIAALKLGAARVIGIDIDPQAIQASRDNAERNGVADQIELYLPADQPQDVEADVVVANILAGPLRELAPLIAGHGKAGSLMALSGVLESQAPELETIYGQWFEMDPTAVKEEWCRLSGRKLG
>NZ_LS483441.1|WP_042014449.1|3534593_3535142_+|sugar-O-acetyltransferase
MTEYEKMIASQPYNCIAPELELLRRETARLYRRFNRSDEEDEQLALLQQIVGELAQGAFICPPLYCTYGRHIHLGKGSYINMGATLLDNAPIRIGAEVMIGPNVQIYTAAHALDADERIQGVETALPVTIEDRVWIGGGAILLPGVTIGREAVVGAGAVVTKDVPAGARVAGNPARLLPVKG
>NZ_LS483441.1|WP_041215688.1|3535162_3536242_-|chemotaxis-protein
MWFNRKLEKENQQLREAMLLKEQQHQSELAELRATIGEYEHMQRTSRERGDLFNQVISCQNQGGEMLQSVREALAGSAEHLMAEKGALCELDQLFAQTRGAITRLSGRAHAITDEAARSLAAVHQLDASTSAINQFVTAIQGISDQTNLLALNAAIEAARAGEAGRGFAVVADEVRQLASKAHEASSQIEVLVRQIVAQAQEIKSIIDDNQASAAEVATSSSQIDVVVTQVLAQSGRMQQVIHSAATTSFLNTTKLDHAVWKNTIYRLIDQQHFHEPVSDHAQCRLGKWYFEGQGAELFAHKPGFRELDGPHKRVHESGKAALHAREQGDIKSMVEQLKTMENASMQVVHCIDRLLESA
>NZ_LS483441.1|WP_010675416.1|3536780_3537329_-|NAD(P)H-nitroreductase
MDALHLLLNRHSCGRLAEPAPSGEVLDNILKAGLRAPDHGTLTPWQFILFEGEGRERLGTLLADAAHARGEDADSVEKCRAAPLRAPLVIAVATRYQAHPKVPKLEQELSAGCALMAMQMAAQAQGFNGIWRSGWFIFDEQIHGALGLAPEDQLVGFLYLGTPMLEARKLRELPIQDFVRSF
>NZ_LS483441.1|WP_042014552.1|3537436_3539464_-|NADPH-dependent-2,4-dienoyl-CoA-reductase
MSRYPTLLTPLDLGFTQLRNRVLMGSMHTGLEEEKGGFDKLAAFYGERARGGVGLIVTGGIAPNLRGRLVPHGSQLSFPWQVAKHRKVTEAVHREGGKIALQILHAGRYAYHPFSLAPSALKAPISPFKPRAMSERQIRGTIRDFAATAALAKAAGYDGVEVMGSEGYLINQFICERTNKRTDGWGGSSENRMRFPVEIVRAIRERVGTDFIIIFRLSMLDLVEQGSSLEEVIALGRALEQVGVTLINTGIGWHEARIPTIATSVPRGAFSWVTAELKKHLKVPLITTNRINTPEVAERILAGGEADMVSMARPFLADPEFVIKAAEDRADEINTCIACNQACLDHVFKQKRASCLVNPRACFETELTFGRVPQPKKLAVVGAGPAGLAFACYAAERGHQVSLFDQASEIGGQFNFAKQIPGKEEFHETLRYFAKRLEKCGVELYLGQRQSAESLLGGGFDEVILATGIRPRTPNIPGIEHPKVLSYLDVLRDHKPVGEKVAVIGAGGIGFDVAEYLVEKRGSPDAASHRDHWLKEWGIDKQLGERGGLTTPEIDAPERQIWLLQRKESKVGDGLGKTTGWIHRTVLKNRKVQMLSGVQYLRIDDAGLHIQVSDQQQCLPVDQVIICAGQEPLKELQAGLQAAGKPVHIIGGADVAAELDAKRAIRQGAELAAVI

Crispr_ID: NZ_LS483441_9

• CRISPR_ID: NZ_LS483441_9
• CRISPR_location: 4206935-4207041
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_LS483441_9

Consensus_repeat	Method
ACCGGTGACACAAGGCCTCCTCGGCTCGCGGGGCAATATC	CRISPRCasFinder

spacers of NZ_LS483441_9

>9.1|4206975|27|NZ_LS483441|CRISPRCasFinder
CGCACTCTTCTGTTGGGCGAGCCGGTA

CRISPR arrays and Neighbor proteins around NZ_LS483441_9

CRISPR arrays

The CRISPR arrays of NZ_LS483441_9

>merge|NZ_LS483441|9|4206935-4207041|CRISPRCasFinder
ACCGGTGACACAAGGCCTCCTCGGCTCGCGGGGCAATATCCGCACTCTTCTGTTGGGCGAGCCGGTAACCGGTGACACAAGGCCTTCTCGGCTCGCGGGGCAATATC

>NZ_LS483441|9|8|4206935-4207041|CRISPRCasFinder
ACCGGTGACACAAGGCCTCCTCGGCTCGCGGGGCAATATC	CGCACTCTTCTGTTGGGCGAGCCGGTA
ACCGGTGACACAAGGCCTTCTCGGCTCGCGGGGCAATATC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LS483441.1|WP_111736104.1|4220264_4220711_-|MSHA-biogenesis-protein-MshP	unknown	unknown	gnl|CDD|227070
NZ_LS483441.1|WP_010672635.1|4213188_4213674_-|rod-shape-determining-protein-MreD	unknown	unknown	gnl|CDD|182936
NZ_LS483441.1|WP_041212219.1|4204284_4204488_+|hypothetical-protein	unknown	unknown	unknown
NZ_LS483441.1|WP_042015333.1|4200205_4201060_+|zinc-metallopeptidase	unknown	unknown	gnl|CDD|282131
NZ_LS483441.1|WP_005308111.1|4214623_4215664_-|rod-shape-determining-protein	unknown	unknown	gnl|CDD|237562
NZ_LS483441.1|WP_042015324.1|4215880_4220239_-|MSHA-biogenesis-protein-MshQ	unknown	unknown	gnl|CDD|173888
NZ_LS483441.1|WP_039040437.1|4201965_4203282_+|MFS-transporter	unknown	unknown	gnl|CDD|340927
NZ_LS483441.1|WP_042015321.1|4221593_4222169_-|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl|CDD|227302
NZ_LS483441.1|WP_029313545.1|4213673_4214582_-|rod-shape-determining-protein-MreC	unknown	unknown	gnl|CDD|237560
NZ_LS483441.1|WP_042015331.1|4203402_4204119_+|MarC-family-NAAT-transporter	unknown	unknown	gnl|CDD|236814
NZ_LS483441.1|WP_042015328.1|4206097_4206904_-|carbon-nitrogen-hydrolase-family-protein	unknown	unknown	gnl|CDD|143596
NZ_LS483441.1|WP_042015330.1|4204591_4206040_-|metalloprotease-TldD	unknown	unknown	gnl|CDD|182685
NZ_LS483441.1|WP_080767927.1|4220721_4221594_-|type-II-secretion-system-protein	unknown	unknown	gnl|CDD|225076
NZ_LS483441.1|WP_010672637.1|4210999_4212469_-|ribonuclease-G	unknown	unknown	gnl|CDD|183285
NZ_LS483441.1|WP_010672636.1|4212548_4213136_-|septum-formation-inhibitor-Maf	unknown	unknown	gnl|CDD|234584
NZ_LS483441.1|WP_042015332.1|4201133_4201811_-|ATP-binding-domain-containing-protein	unknown	unknown	gnl|CDD|238952
NZ_LS483441.1|WP_039040440.1|4199867_4200131_+|hypothetical-protein	unknown	unknown	unknown
NZ_LS483441.1|WP_042015334.1|4199204_4199726_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379112
NZ_LS483441.1|WP_010672653.1|4198924_4199101_+|hypothetical-protein	unknown	unknown	unknown
NZ_LS483441.1|WP_042015326.1|4207096_4210999_-|TIGR02099-family-protein	unknown	unknown	gnl|CDD|273971

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_LS483441.1|WP_111736104.1|4220264_4220711_-|MSHA-biogenesis-protein-MshP	gnl|CDD|227070	COG4726, PilX, Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion].	0.000147272
NZ_LS483441.1|WP_042015324.1|4215880_4220239_-|MSHA-biogenesis-protein-MshQ	gnl|CDD|173888	cd06900, lectin_VcfQ, VcfQ bacterial pilus biogenesis protein, lectin domain. This family includes bacterial proteins homologous to the VcfQ (also known as MshQ) bacterial pilus biogenesis protein. VcfQ is encoded by the vcfQ gene of the type IV pilus gene cluster of Vibrio cholerae and is essential for type IV pilus assembly. VcfQ has a Laminin G-like domain as well as an L-type lectin domain.	5.31322e-95
NZ_LS483441.1|WP_042015328.1|4206097_4206904_-|carbon-nitrogen-hydrolase-family-protein	gnl|CDD|143596	cd07572, nit, Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases). This subgroup includes mammalian Nit1 and Nit2, the Nit1-like domain of the invertebrate NitFhit, and various uncharacterized bacterial and archaeal Nit-like proteins. Nit1 and Nit2 are candidate tumor suppressor proteins. In NitFhit, the Nit1-like domain is encoded as a fusion protein with the non-homologous tumor suppressor, fragile histidine triad (Fhit). Mammalian Nit1 and Fhit may affect distinct signal pathways, and both may participate in DNA damage-induced apoptosis. Nit1 is a negative regulator in T cells. Overexpression of Nit2 in HeLa cells leads to a suppression of cell growth through cell cycle arrest in G2. These Nit proteins and the Nit1-like domain of NitFhit belong to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 10.	1.61979e-143
NZ_LS483441.1|WP_042015333.1|4200205_4201060_+|zinc-metallopeptidase	gnl|CDD|282131	pfam04228, Zn_peptidase, Putative neutral zinc metallopeptidase. Members of this family have a predicted zinc binding motif characteristic of neutral zinc metallopeptidases (Prosite:PDOC00129).	5.92454e-146
NZ_LS483441.1|WP_005308111.1|4214623_4215664_-|rod-shape-determining-protein	gnl|CDD|237562	PRK13927, PRK13927, rod shape-determining protein MreB; Provisional.	0
NZ_LS483441.1|WP_039040437.1|4201965_4203282_+|MFS-transporter	gnl|CDD|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.42819e-83
NZ_LS483441.1|WP_042015321.1|4221593_4222169_-|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl|CDD|227302	COG4967, PilV, Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion].	4.04093e-06
NZ_LS483441.1|WP_029313545.1|4213673_4214582_-|rod-shape-determining-protein-MreC	gnl|CDD|237560	PRK13922, PRK13922, rod shape-determining protein MreC; Provisional.	5.93062e-104
NZ_LS483441.1|WP_042015331.1|4203402_4204119_+|MarC-family-NAAT-transporter	gnl|CDD|236814	PRK10995, PRK10995, MarC family NAAT transporter.	2.30555e-99
NZ_LS483441.1|WP_010672635.1|4213188_4213674_-|rod-shape-determining-protein-MreD	gnl|CDD|182936	PRK11060, PRK11060, rod shape-determining protein MreD; Provisional.	2.75256e-57
NZ_LS483441.1|WP_042015330.1|4204591_4206040_-|metalloprotease-TldD	gnl|CDD|182685	PRK10735, tldD, protease TldD; Provisional.	0
NZ_LS483441.1|WP_080767927.1|4220721_4221594_-|type-II-secretion-system-protein	gnl|CDD|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	9.34278e-07
NZ_LS483441.1|WP_010672637.1|4210999_4212469_-|ribonuclease-G	gnl|CDD|183285	PRK11712, PRK11712, ribonuclease G; Provisional.	0
NZ_LS483441.1|WP_010672636.1|4212548_4213136_-|septum-formation-inhibitor-Maf	gnl|CDD|234584	PRK00032, PRK00032, septum formation inhibitor Maf.	4.5201e-104
NZ_LS483441.1|WP_042015332.1|4201133_4201811_-|ATP-binding-domain-containing-protein	gnl|CDD|238952	cd01994, Alpha_ANH_like_IV, This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily of proteins is predicted to bind ATP. This domainhas a strongly conserved motif SGGKD at the N terminus.	7.42067e-52
NZ_LS483441.1|WP_042015334.1|4199204_4199726_-|GNAT-family-N-acetyltransferase	gnl|CDD|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	1.42905e-29
NZ_LS483441.1|WP_042015326.1|4207096_4210999_-|TIGR02099-family-protein	gnl|CDD|273971	TIGR02099, probable_transmembrane_protein, TIGR02099 family protein. This model describes a family of long proteins, over 1250 amino acids in length and present in the Proteobacteria. The degree of sequence similarity is low between sequences from different genera. Apparent membrane-spanning regions at the N-terminus and C-terminus suggest the protein is inserted into (or exported through) the membrane. [Hypothetical proteins, Conserved].	0

Protein sequences

>NZ_LS483441.1|WP_042015328.1|4206097_4206904_-|carbon-nitrogen-hydrolase-family-protein
MWLAAMQLISGRTWQDNRERIAAELASLPGERPLLVLLPENFALFGERQGYLDGAEPLGNGPIQQQLSDWAKSHGIWLVAGAMPTAIAGADHIHTSTLVFDPDGELKGHYHKIHLFDVDVADNHGRYRESETFSPGDQPVLVDSPFGPLGLSICYDLRFPELYRQLARAGARVLLVPAAFTAVTGEAHWEPLLRARAIENQCYVVAANQGGTHETGRKTWGHSMVIDPWGRVLACRASGQGTVLAPLDGALIDELKRTMPVLQHARLL
>NZ_LS483441.1|WP_042015330.1|4204591_4206040_-|metalloprotease-TldD
MSLLSQVSASLLAPNDLDEGRLQQLLGSLMSHQVEFGDLYFQRSWHESWMLEDGIVKDGSYNIDQGVGVRAVSGEKTGFAYSDELSLLALQQSVTAARGIAAAGAQGKVKAWARTEANLLYPALDPLQTLDKQQKIALLEQMDKFARGLDPAINQVMASISGVYEEVLVAATDGTLAADVRPLVRLSVTVIAEKGDRRERGSAGGGGRFGYDYFLALDGLESRAFGYVREAVRQALVNLDAIDAPAGTMPVVLGAGWPGVLLHEAVGHGLEGDFNRKGSSAFAGRIGEQVASKHCTIVDDGTLPGRRGSVSIDDEGTPGGYNVLIENGILKGYLQDKQNARLMGVPLTGNGRRESYAALPMPRMTNTYMLAGQYDPAEIIASVKKGIYAPNFGGGQVDITSGKFVFSASEAYLIEDGRITAPIKGATLIGNGPEAMSQVSMVGRDLALDRGVGVCGKEGQSVPVGVGQPTLKLDQLTVGGTQ
>NZ_LS483441.1|WP_041212219.1|4204284_4204488_+|hypothetical-protein
MEKMLTEIGSYSLFHEYLNVVGAASPALTRIKTGWEFKRKDRLLAQIRVDDHGHARFFIDARAISVN
>NZ_LS483441.1|WP_042015331.1|4203402_4204119_+|MarC-family-NAAT-transporter
MFFQVVFLALLALLPMVNPPTTATLLLGLSKGMSREHIRRQINMAALYLFATLCVSFFIGSSILDLFGISIPGLRLAGGLIIAFIGFRMLFPSPNQSAGVEANQNIAFVPLTMPSMCGPGTMALVISGAAQIAELPAEADRVVIYAAMVTAFALMSLISWGVLKLADPVCKILGATGIDAMTRIMGFLLVCMGMQFCINGVKEVAQDPVFHGQVMEQPAAALPSHAGSTTLDHLAVPR
>NZ_LS483441.1|WP_039040437.1|4201965_4203282_+|MFS-transporter
MSKVSTSHDHGRPLNRQDYKTLSLAALGGALEFYDFIIFVFFAVVIGELFFPADIPEWLRQFQTFGIFAAGYLARPLGGIIMAHFGDLIGRKRMFTLSIILMALPTLLIGLLPTYAVLGIAAPLLLLLLRILQGAAIGGEVPGAWVFVAEHVPARRVGVACGTLTAGLTAGILLGSLVATAINRGMSPGDVSDWGWRLAFVLGGVFGIVAMYLRRWLHETPVFAEMQANKSLAEELPLKTVLREHKGSVVVSMLLTWLLSAGIVVVILMTPTYLQKVHGISPADALTANSLAIVALTLGCIVYGRLIDAIGSGPTFILGSLLLAGATYTFYHSLAAGTDQLVPLYMLAGFAVGIVGAVPYVMVNAFPPVVRFSGLSFSYNVAYAIFGGLTPMLVTLWMKEDVLAPSHYVVSLAALGFVLGIWLWLRQRGQRQATPQAA
>NZ_LS483441.1|WP_042015332.1|4201133_4201811_-|ATP-binding-domain-containing-protein
MTKKKVLLSWSSGKDSAWALHRLREDPAIEVVGLFTTLNQAFERVAMHGVRKQLLLAQAECVGLPLITIDLPWPCSNEEYGRIMTGFIADVQAKGIHHMAFGDLFLEDVRAYRERQLAGTGITPLFPLWGSDTTELAQAMIDAGLKARVCTLDPGKLDAGLGGHEFGPAFLAALPAGVDPCGENGEFHTLAWDGPMFLHPLPIRVGETVLRDGFVFTDLLAEDPE
>NZ_LS483441.1|WP_042015333.1|4200205_4201060_+|zinc-metallopeptidase
MRWQDRRESNNVEDRRQQGGGNGGGGLPIGGKGRLILLVVVMVAGYYGVDLGPLLQDPAPQSQPQRQNSSQAANDPLARFTSVMLASTEDAWGEMFQQSGNHYQAPRLVLYRGATRTGCGQGQSVMGPFYCPADSTVYIDLSFYQDMRDKLGADGDFAQGYVIAHEVGHHVQNLLGISTKVRQQQQGLSQVAQNRLSVKLELQADCFAGVWGHYMEKEQVLERGDLEEALNAAQAIGDDRLQQQGQGRVVPDSFTHGTSAQRLAWFKRGFDSGKPASCDTFAAR
>NZ_LS483441.1|WP_039040440.1|4199867_4200131_+|hypothetical-protein
MTDTPEFFDEETLLEMVENQLADGHPLQVKATLMRLVMKGTPREEALQYIACALGAELMAMEAEQGPFNLVRYGEFLDSLPEMPWAE
>NZ_LS483441.1|WP_042015334.1|4199204_4199726_-|GNAT-family-N-acetyltransferase
MILSERLELRKLTIVDAPFILELLNDGDFHRYIGDRGVRTLADAENYIQQGPAVSYARHGHGLYLVVRREDGARLGICGLIKRDTLPCEDIGYAFLPAWRGQGYAIEAARAAMADGRERLGIERVVAIVTPGNERSVRLLAKLGLSQGKRVRLGAGEEECLLLEAPDKETCGV
>NZ_LS483441.1|WP_010672653.1|4198924_4199101_+|hypothetical-protein
MMKHVQIRKPLRRSKPINLPVQEHDDDAFLIQFSTRFSGGFAISCDGIAGEFSIEELN
>NZ_LS483441.1|WP_042015326.1|4207096_4210999_-|TIGR02099-family-protein
MVYRWLSRGWLALGVFFVLLAVLVSVVRLGGPLLNQHRAAVIGTLLGESQLEVSVDHVGLDWTPRGPAIGLEGLAIAPDSGRFSLRLGKVWAHLDFWRSLNELRPVFGQLILSDGNIALDMTQPATPVSGKSANQQEALLRFLLTQLSTFDIHDTRLSLTTALGEVRALDIAQLRWQNRGKRHQGVGKAYLINGVGESTLDLIIDVDAPEVRLDRLKGQLYLGARELDISPMLARIHAGAPPVSGQLDFQLWSEFEKGRLGNSLLAFGNNHLIWKDEIKGEPHRLDLQGGKIQLRRDGEAWQLASHDVIFKLDGATWLHSRLQLERIGSRIQGYVPAIDLDQIANLSQLVSGLYPELTETLKRTRPRGQLQELVLQADGDWQGLSLQGQLRGFGTRAWHDVPGLQKLDGDFWLTPNGGRARLTLGKGKVDPARHFKEPIPVDSLSAALDWWRAPQGWVLYGQDIALDNPDLRLASRFRLELFEHPFLALTGRIDVKNAAHADRYYPLAVMDEGLVSYLSGAIKGGKAKGADLLWYGEFRDFPYDNGKGVFQVAVPLQQATYEFFPGWQPLTDLQIDLLFQNASLDMNSRATQLGKASSDSVHAWIPDLYPGAHLYVDARVEGEGKAISDYLQDSPLGGSVGQALREVEIRGPMKGTVKLDIPLDGEGEVKASGEASFKNNKVRIASLDLPLDGVAGTLEYDNEQTRIHNLKASLWNQPLTLDYQGRQLPHGYQADLKFQGQWDSRRQRRDIPALEMLQGRSNWSGTLGLTLPENKAFSFQLALDSNLQGMGLDLPVPLTKAAGTRLPLKVTARGRDGSADIRAVLGADIDMQSRLVYGDGVPYLSRVRVNIGQPGARVMQDKPMLLAINQQQADVAGWLARLKQWLPAKAQATQGNAVVGPAFLPQEWWVDGQLARADIGSASLKAVHFTLGPVNQATEVMIDSPDVMGVVRVPVADGRPIDAKFARIYWSGKGTDLSPDPDERQDRAIMNAIPWLTFSCVDCRFGELPLGEVKGELLPGANRLDLKGLEMRLAGSTLRGSAEWLARGSQMQTRARVNLETRNSELLLKRLGYTSPIGDAPGKLALDLNWRDVPYRLSLPTLAGSADYQLEGGTLREVNDKGARLLSLLSLDSLMRKLRLDFRDVFDKGFYFESMSASAKVNQGVVENNDFYMKGAAGNLRGKGIADLVRWRLDFDLSFSPNLGGTLPVVAAFSLTPITGLYVLALSKLLEPVVDVVTRIDFRVSGPLDAPKLVEAGRDRARIKLNQQQKEAVDAVAPGLPAKEVTPFLLNPKHQGSGQR
>NZ_LS483441.1|WP_010672637.1|4210999_4212469_-|ribonuclease-G
MSVELLVNVTPSETRVALVENGLLQEVHVERQAKRGIVGNIYKGKISRVLPGMQAAFVDIGMDKAAFLHASDIVPHTECVAIKEKEQFQAGNIAELVRQGQDIMVQVVKDPLGTKGARLTTDITLPSRYLVFMPGSAHVGVSQRIESEAERERLKRTVAGYVDELGGYIIRTAAEGVGEQELEQDAAFLKRLWRKILERKQKYPPCKILYEDPSLAFRVVRDFVGAELDKIRVDSRQSFDQLKRFTEEYVPELANKLEYYTGESPIFDLYDVENEIQRALERKVELKSGGYLIIDQTEAMTTVDINTGAFVGHRNLEETIFNTNVEATAAIARHLRLRNLGGIIIIDFIDMQSEDHRRRVLHSLELALAKDRAKTNVNGFSQLGLVEMTRKRTRESLEHVLCAECPECKGRGRVKTVESVCFEILREIIRVNRAYDADQFTVYAAPSVADYLRGEESHSLAELEVFIGKQVRVVSEPLCGQEQFDVVMM
>NZ_LS483441.1|WP_010672636.1|4212548_4213136_-|septum-formation-inhibitor-Maf
MNKHNELQLYLASGSPRRHELLTRLGYRFEVLKLDVPELRNDGEKPQDYVCRLARDKAMAGVAAAPTALPVLGADTIVVLGERVLEKPSDLLDAKDMLEALSGRVHQVMTAVALATPERCDVRLVTTNVAFRKLDEAEIEAYWRTGEPCDKAGAYAIQGIAGKFVSRLEGSYSAVVGLPLLETDLLIKQHLEQTR
>NZ_LS483441.1|WP_010672635.1|4213188_4213674_-|rod-shape-determining-protein-MreD
MLQPASGRIWIWCSILLALCLSILPLPFQFEPFRPDWLAMVLIYWALALPHRTNVGTAWVAGLLLDVLLGSTLGVRAMAMAITTYLAAFQFQKIRNFSLWQQALIIGLLSLVGKITVFWAEHLFSRASLNFAYFWSTLTTMLIWPWIFMVLRKVRRRFNIK
>NZ_LS483441.1|WP_029313545.1|4213673_4214582_-|rod-shape-determining-protein-MreC
MKPIFGRGPSLQLRLFLAVIISVAAIVADSRFGVFSHVRVYLSSLVSPLQYIANAPGTLLDTMSTQVQTRADLIEQTKQQEQQLFTLRSRLLKMDQLEHENQRLRELLGSPVHKESRKMVAELLSVDSDPFSHQVLINKGALDGVYNGQPVINDQGVVGQVLHVGSTTSRVLLITDSSHGIPVRVLRNDLRAIASGSGELDKLELRNLPRNTDVQVGDLLVTSGLGGRFPEGYPVATVTRSDYVEGKPFAQIEAKPLVALDRLRYLLLLWTDKKPEVHDKDALEPAASASAATATSAAGATR
>NZ_LS483441.1|WP_005308111.1|4214623_4215664_-|rod-shape-determining-protein
MFKKLRGVFSNDLSIDLGTANTLIYVKDQGIVLNEPSVVAIRQERGNAKSVAAVGHAAKQMLGRTPGNISAIRPMKDGVIADFYVTEKMLQHFIKQVHDNNYFRPSPRVLVCVPCGSTQVERRAIKESALGAGAREVYLIDEPMAAAIGAGLPVSEATGSMVVDIGGGTTEVAIISLNGVVYSQSVRIGGDKFDEAIISYVRRNYGSLIGEATAERIKHEIGSAYPGEEVREIEVRGRNLAEGVPRSFTLNSNEILEALQEPLSGIVSAVMVALEQSPPELASDISERGMVLTGGGALLKDIDRLLMEETGIPVVVAEDPLTCVARGGGKALELIDMHGGDLFHYE
>NZ_LS483441.1|WP_042015324.1|4215880_4220239_-|MSHA-biogenesis-protein-MshQ
MKSSQPLRGALLWILLGSTSVQAASQCTEAFLFPVQSHASPGVLSMNNESKIISTTVGASYPFLTKNIQPNANCNNGGFWNNGTWVSNCNVSGTLASVLKDVTFISDPDAFPANPGGFPSYSGKNDLACDGTTSPAAGDYKNASWGGNSCVATLKSGQTYRFDTLSISEGAMLNLNGATVYAQKMTIKNGYNSGVTGSGDLHVNDLTVTGQGKLNDARVTVYSTLEVSGNGNTGTAVFQPHYLDKVTMEVSASGQSVLMGAGDWFIKSLGMKSNSAMTFQGQSSLAVYGLKMENESRISAAGSRSDLTLQLHQTLEVSGNGTINGYLQARYLKTFKHQSTSNINFYFRGGNHWIDKMELGQNDKLIFDSGSAARLYIKSDLALSDQMEVNAGGKANDLMMYHFGKVTMSGNTKLNAILYVNTGDLAMSGQAVLTGAVSAVNVSMTNNSKVIHEPFNGDWPGMCEDPLTCFSDDFSASTLGSDWVVAQRNGSTLPSLQNGRLRLTQNTTNQATSATFQRLFPGASNLVTIEFDQYAYKTSGSSGADGMAVVLSDATITPQPGAFGGPLGYGFKTGISGFAGGWMGVGIDEYGNYANEGGSYNPGSRPQAVSIRGSGASSGTSGYRYLAGTASNLSPAVDSGTNGNRPHRYRITIDSRTAGSSLASVERNTGSGYTMLVGPINMVNQTGQAAVPANFLLSLTGSTGSVTNYHELDNVRICALKSNPVGTQIDHFEFDHSGQALTCNPETLVIRACANASCSQLFTDPVSAILTPLKNGSNGWIADSQVSYNGNTATVNFSGGTTTLQLRNNLATAITVGVSGSTPSTKPLSTTLCRAGSGALSAAACTLSFADSGFLFNVPDTLANRPQDVVISAVKKDNATQQCVPGFTGERSVGFWGTYVTPNDNSAGSQMAIDGKTISTYAANVVSPAATTLNLTFDGQGKATLKSVRYPDAGQMRLNARHDGSGDTAGLVMTGSDLFVSRPVGLCITPTQGTCAAGDITCPVFKRTGDSFSLNIQAMAWQSDSDGDICIGNGTTPNFVLSDIALTSELVAPQGGVAAQVTPTRYSHVAASASLNTPALSLNEVGVFRIKATPPVATSPEGSTVSTGYFGYSIPPATSVPLGRFVPWDFNMTSGTVTPACGGFSYMSQPFGVQTVVEARNKEGSVTRNYRDAFARGALTLVAANNQDGVDRSNRLAPLAASWTEGTGKQSGQTRFMRLRELTPSLTAPEEPLPLLRLGLRVTDGETPETSFLSGRNMNPAVSGTCQSGVNCTAKQLSIPKGSDDTMIAYYGRLLASTRQGVDSAPLALPLQVQYFEGGLWRANSQDRRANSQDICTQISLAGGGIVFTDAEQRYDSATGDLILKDGTRIRLGLGNVAPGGTQVGFDAGETRFHFAPPNQAVRIPYRIVLEQQPSQPVWLADPATTGHLQGEAIFGRDRGNDRIIYRREVMP
>NZ_LS483441.1|WP_111736104.1|4220264_4220711_-|MSHA-biogenesis-protein-MshP
MVRSQRGSSILIALFVIVIMALLAAAMGRFLVDSSEKHTVEVRGVRALMAAQSGLEVALYRLYPNGEWQGQASRCVPIALDFTEPGLAGCQASITCNRVTVSAAGGTQTGYRFSSEGRCGQPDAGSGPNPDFAVSRTLVAEAFDGATP
>NZ_LS483441.1|WP_080767927.1|4220721_4221594_-|type-II-secretion-system-protein
MDQPHSRYAASDDAAVTIPRYRVRSGFAHRACAQPGRGRGFTLVELVMVILLLGVMATFSSQFIGIGTQIYGDASRREQLMSDARFALERLNRELRDAVPGSVRIEDEAGKGADQGTCLRFWPIATASRYLGSVASAGLNIVVPDALPREKDQAIVYPLADPALGLDQGCLHGNCVAAVTSVGSPISGALPLTVDGTFAKESPGQRIYFARQQVRYCVTNAALTRVSAAIGADISLGTSALMAEHIRPASYYFYREPAAFNQSEVGLRLEFEQRDERVVFHHKLETLNVP
>NZ_LS483441.1|WP_042015321.1|4221593_4222169_-|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MPSLKARRGFTLIEFVVGIVLLAIALTGILGLLINQAPQAVDPVQQVRAAQLAQRILSEVLQKSFDEHSDHNGGRFRCGETVGTPAVTYPPCTASADYGPEGGETRPYAFNDVDDFDTGGHWVDANLFTQTDAEGVSDQEYRHYQIRIAVTPDTLFGSTGPGAESIGKRVALTVRLPDESELAFALYRGNY

Crispr_ID: NZ_LS483441_10

• CRISPR_ID: NZ_LS483441_10
• CRISPR_location: 4224394-4224492
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_LS483441_10

Consensus_repeat	Method
CCCCGCACGGCCCGCATCATCTCCC	CRISPRCasFinder

spacers of NZ_LS483441_10

>10.1|4224419|49|NZ_LS483441|CRISPRCasFinder
CGCCATTGGGAGAGTGAAGATGCTGGTTGCACAGATAACTCACGACTGA

CRISPR arrays and Neighbor proteins around NZ_LS483441_10

CRISPR arrays

The CRISPR arrays of NZ_LS483441_10

>merge|NZ_LS483441|10|4224394-4224492|CRISPRCasFinder
CCCCGCACGGCCCGCATCATCTCCCCGCCATTGGGAGAGTGAAGATGCTGGTTGCACAGATAACTCACGACTGACCCCGCACGGCCCGCATCATGTCCC

>NZ_LS483441|10|9|4224394-4224492|CRISPRCasFinder
CCCCGCACGGCCCGCATCATCTCCC	CGCCATTGGGAGAGTGAAGATGCTGGTTGCACAGATAACTCACGACTGA
CCCCGCACGGCCCGCATCATGTCCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LS483441.1|WP_111736104.1|4220264_4220711_-|MSHA-biogenesis-protein-MshP	unknown	unknown	gnl|CDD|227070
NZ_LS483441.1|WP_042015324.1|4215880_4220239_-|MSHA-biogenesis-protein-MshQ	unknown	unknown	gnl|CDD|173888
NZ_LS483441.1|WP_042015305.1|4234928_4236848_-|RNase-E-specificity-factor-CsrD	unknown	unknown	gnl|CDD|236833
NZ_LS483441.1|WP_005308111.1|4214623_4215664_-|rod-shape-determining-protein	unknown	unknown	gnl|CDD|237562
NZ_LS483441.1|WP_042015309.1|4233033_4233897_-|hypothetical-protein	unknown	unknown	gnl|CDD|227306
NZ_LS483441.1|WP_042015307.1|4234017_4234932_+|pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|225313
NZ_LS483441.1|WP_029313545.1|4213673_4214582_-|rod-shape-determining-protein-MreC	unknown	unknown	gnl|CDD|237560
NZ_LS483441.1|WP_010672628.1|4222703_4223165_-|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl|CDD|225076
NZ_LS483441.1|WP_042015312.1|4231794_4232442_-|MSHA-biogenesis-protein-MshJ	unknown	unknown	gnl|CDD|377391
NZ_LS483441.1|WP_042015314.1|4228648_4229539_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|132060
NZ_LS483441.1|WP_141651384.1|4229529_4229712_-|hypothetical-protein	unknown	unknown	unknown
NZ_LS483441.1|WP_042015321.1|4221593_4222169_-|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl|CDD|227302
NZ_LS483441.1|WP_010672629.1|4222155_4222638_-|type-II-secretion-system-protein	unknown	unknown	gnl|CDD|225076
NZ_LS483441.1|WP_042015320.1|4223183_4223843_-|type-II-secretion-system-protein	unknown	unknown	gnl|CDD|225076
NZ_LS483441.1|WP_042015316.1|4225728_4227441_-|type-II/IV-secretion-system-protein	unknown	unknown	gnl|CDD|225363
NZ_LS483441.1|WP_080767927.1|4220721_4221594_-|type-II-secretion-system-protein	unknown	unknown	gnl|CDD|225076
NZ_LS483441.1|WP_010672620.1|4229690_4231367_-|pilus-(MSHA-type)-biogenesis-protein-MshL	unknown	unknown	gnl|CDD|274176
NZ_LS483441.1|WP_039040513.1|4231436_4231739_-|MSHA-biogenesis-protein-MshK	unknown	unknown	unknown
NZ_LS483441.1|WP_042015319.1|4223920_4224382_-|hypothetical-protein	unknown	unknown	unknown
NZ_LS483441.1|WP_042015315.1|4227515_4228652_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|274350

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_LS483441.1|WP_111736104.1|4220264_4220711_-|MSHA-biogenesis-protein-MshP	gnl|CDD|227070	COG4726, PilX, Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion].	0.000147272
NZ_LS483441.1|WP_042015324.1|4215880_4220239_-|MSHA-biogenesis-protein-MshQ	gnl|CDD|173888	cd06900, lectin_VcfQ, VcfQ bacterial pilus biogenesis protein, lectin domain. This family includes bacterial proteins homologous to the VcfQ (also known as MshQ) bacterial pilus biogenesis protein. VcfQ is encoded by the vcfQ gene of the type IV pilus gene cluster of Vibrio cholerae and is essential for type IV pilus assembly. VcfQ has a Laminin G-like domain as well as an L-type lectin domain.	5.31322e-95
NZ_LS483441.1|WP_042015305.1|4234928_4236848_-|RNase-E-specificity-factor-CsrD	gnl|CDD|236833	PRK11059, PRK11059, regulatory protein CsrD; Provisional.	0
NZ_LS483441.1|WP_005308111.1|4214623_4215664_-|rod-shape-determining-protein	gnl|CDD|237562	PRK13927, PRK13927, rod shape-determining protein MreB; Provisional.	0
NZ_LS483441.1|WP_042015309.1|4233033_4233897_-|hypothetical-protein	gnl|CDD|227306	COG4972, PilM, Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion].	0.001055
NZ_LS483441.1|WP_042015307.1|4234017_4234932_+|pyridoxal-phosphate-dependent-enzyme	gnl|CDD|225313	COG2515, Acd, 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism].	1.2457e-54
NZ_LS483441.1|WP_029313545.1|4213673_4214582_-|rod-shape-determining-protein-MreC	gnl|CDD|237560	PRK13922, PRK13922, rod shape-determining protein MreC; Provisional.	5.93062e-104
NZ_LS483441.1|WP_010672628.1|4222703_4223165_-|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl|CDD|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	2.254e-09
NZ_LS483441.1|WP_042015312.1|4231794_4232442_-|MSHA-biogenesis-protein-MshJ	gnl|CDD|377391	pfam04612, T2SSM, Type II secretion system (T2SS), protein M. This family of membrane proteins consists of Type II secretion system protein M sequences from several Gram-negative (diderm) bacteria. The precise function of these proteins is unknown, though in Vibrio cholerae, the T2SM (EpsM) protein interacts with the T2SL (EpsL) protein, and also forms homodimers.	0.00149546
NZ_LS483441.1|WP_042015314.1|4228648_4229539_-|AAA-family-ATPase	gnl|CDD|132060	TIGR03015, pepcterm_ATPase, putative secretion ATPase, PEP-CTERM locus subfamily. Members of this protein are marked as probable ATPases by the nucleotide binding P-loop motif GXXGXGKTT, a motif DEAQ similar to the DEAD/H box of helicases, and extensive homology to ATPases of MSHA-type pilus systems and to GspA proteins associated with type II protein secretion systems. [Protein fate, Protein and peptide secretion and trafficking].	1.21183e-75
NZ_LS483441.1|WP_080767927.1|4220721_4221594_-|type-II-secretion-system-protein	gnl|CDD|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	9.34278e-07
NZ_LS483441.1|WP_010672629.1|4222155_4222638_-|type-II-secretion-system-protein	gnl|CDD|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	1.73255e-07
NZ_LS483441.1|WP_042015320.1|4223183_4223843_-|type-II-secretion-system-protein	gnl|CDD|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	4.06106e-08
NZ_LS483441.1|WP_042015316.1|4225728_4227441_-|type-II/IV-secretion-system-protein	gnl|CDD|225363	COG2804, PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion].	0
NZ_LS483441.1|WP_042015321.1|4221593_4222169_-|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl|CDD|227302	COG4967, PilV, Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion].	4.04093e-06
NZ_LS483441.1|WP_010672620.1|4229690_4231367_-|pilus-(MSHA-type)-biogenesis-protein-MshL	gnl|CDD|274176	TIGR02519, related_to_type_II_protein_secretion_protein, pilus (MSHA type) biogenesis protein MshL. Members of this family are predicted secretins, that is, outer membrane pore proteins associated with delivery of proteins from periplasm to the outside of the cell. Related families include GspD of type II secretion (TIGR02517), the YscC/HrcC family from type III secretion (TIGR02516), and the PilQ secretin of type IV pilus formation (TIGR02515). Members of this family are found in gene clusters associated with MSHA (mannose-sensitive hemagglutinin) and related pili, and appear to be the secretin of this pilus system. [Cell envelope, Surface structures].	1.32081e-86
NZ_LS483441.1|WP_042015315.1|4227515_4228652_-|tetratricopeptide-repeat-protein	gnl|CDD|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	3.90348e-10

Protein sequences

>NZ_LS483441.1|WP_042015319.1|4223920_4224382_-|hypothetical-protein
MSRQSEQDERWLGGYRRLIACILLLVILATLALSYRSHREEALAVSLTLLGEQFAERVQRLHGRWLDERRPAVLHAEGRAWQFDGRGWPLAVLPLQSPSENCRGLWSALLGQEALSMPTLQVLASPDGEGCEFGWEANWLIYRFADGSLLNKS
>NZ_LS483441.1|WP_042015320.1|4223183_4223843_-|type-II-secretion-system-protein
MATKRVIPGQGPGQMAGFSLIELVIVIVILGILAVTALPRFLDVTDEAKKASVEGVSGGFATGVSLVRAQWEAEGRARQDGLNTVLYDGSRFYLTTPTDSQVSNGELSPGYPMDTAASGAPDVDPANLTAARCLNIWEGLLQNPPKATARFDEVRGSGNDLKFYATVSNNGLDSVCRYYLVNSLSKGSDGRYQDPQGSTDAFMSFSYRPASGQVTTNIN
>NZ_LS483441.1|WP_010672628.1|4222703_4223165_-|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MKKQAGFTLIELVIVIIILGILAVTAAPKFLNLQDDARTSTLKGVEGSLNSAGAMVYSKAVIAGKDTTASDTLDIGNGVDVGIAFGYPKATKDDLEKVLQLSTNDWSFGTPASSSIKIFPAGVSASTATDCYVTYTQAITSGSQPTAAVTACK
>NZ_LS483441.1|WP_010672629.1|4222155_4222638_-|type-II-secretion-system-protein
MTERDEGFTLIELVIVILLLGILAAFAVPKWLGKGGFETHTLRDELVARLRLVQTMNMQEGEARCTQLVLEPSRFGHLTLLGSCTPKPISGWSADEQSRGRVITASGGLSLPQGSFSFDKRSGRPLSPSTCVNGCNLVVSSGQESARLRIEPEGYIHALP
>NZ_LS483441.1|WP_042015321.1|4221593_4222169_-|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MPSLKARRGFTLIEFVVGIVLLAIALTGILGLLINQAPQAVDPVQQVRAAQLAQRILSEVLQKSFDEHSDHNGGRFRCGETVGTPAVTYPPCTASADYGPEGGETRPYAFNDVDDFDTGGHWVDANLFTQTDAEGVSDQEYRHYQIRIAVTPDTLFGSTGPGAESIGKRVALTVRLPDESELAFALYRGNY
>NZ_LS483441.1|WP_080767927.1|4220721_4221594_-|type-II-secretion-system-protein
MDQPHSRYAASDDAAVTIPRYRVRSGFAHRACAQPGRGRGFTLVELVMVILLLGVMATFSSQFIGIGTQIYGDASRREQLMSDARFALERLNRELRDAVPGSVRIEDEAGKGADQGTCLRFWPIATASRYLGSVASAGLNIVVPDALPREKDQAIVYPLADPALGLDQGCLHGNCVAAVTSVGSPISGALPLTVDGTFAKESPGQRIYFARQQVRYCVTNAALTRVSAAIGADISLGTSALMAEHIRPASYYFYREPAAFNQSEVGLRLEFEQRDERVVFHHKLETLNVP
>NZ_LS483441.1|WP_111736104.1|4220264_4220711_-|MSHA-biogenesis-protein-MshP
MVRSQRGSSILIALFVIVIMALLAAAMGRFLVDSSEKHTVEVRGVRALMAAQSGLEVALYRLYPNGEWQGQASRCVPIALDFTEPGLAGCQASITCNRVTVSAAGGTQTGYRFSSEGRCGQPDAGSGPNPDFAVSRTLVAEAFDGATP
>NZ_LS483441.1|WP_042015324.1|4215880_4220239_-|MSHA-biogenesis-protein-MshQ
MKSSQPLRGALLWILLGSTSVQAASQCTEAFLFPVQSHASPGVLSMNNESKIISTTVGASYPFLTKNIQPNANCNNGGFWNNGTWVSNCNVSGTLASVLKDVTFISDPDAFPANPGGFPSYSGKNDLACDGTTSPAAGDYKNASWGGNSCVATLKSGQTYRFDTLSISEGAMLNLNGATVYAQKMTIKNGYNSGVTGSGDLHVNDLTVTGQGKLNDARVTVYSTLEVSGNGNTGTAVFQPHYLDKVTMEVSASGQSVLMGAGDWFIKSLGMKSNSAMTFQGQSSLAVYGLKMENESRISAAGSRSDLTLQLHQTLEVSGNGTINGYLQARYLKTFKHQSTSNINFYFRGGNHWIDKMELGQNDKLIFDSGSAARLYIKSDLALSDQMEVNAGGKANDLMMYHFGKVTMSGNTKLNAILYVNTGDLAMSGQAVLTGAVSAVNVSMTNNSKVIHEPFNGDWPGMCEDPLTCFSDDFSASTLGSDWVVAQRNGSTLPSLQNGRLRLTQNTTNQATSATFQRLFPGASNLVTIEFDQYAYKTSGSSGADGMAVVLSDATITPQPGAFGGPLGYGFKTGISGFAGGWMGVGIDEYGNYANEGGSYNPGSRPQAVSIRGSGASSGTSGYRYLAGTASNLSPAVDSGTNGNRPHRYRITIDSRTAGSSLASVERNTGSGYTMLVGPINMVNQTGQAAVPANFLLSLTGSTGSVTNYHELDNVRICALKSNPVGTQIDHFEFDHSGQALTCNPETLVIRACANASCSQLFTDPVSAILTPLKNGSNGWIADSQVSYNGNTATVNFSGGTTTLQLRNNLATAITVGVSGSTPSTKPLSTTLCRAGSGALSAAACTLSFADSGFLFNVPDTLANRPQDVVISAVKKDNATQQCVPGFTGERSVGFWGTYVTPNDNSAGSQMAIDGKTISTYAANVVSPAATTLNLTFDGQGKATLKSVRYPDAGQMRLNARHDGSGDTAGLVMTGSDLFVSRPVGLCITPTQGTCAAGDITCPVFKRTGDSFSLNIQAMAWQSDSDGDICIGNGTTPNFVLSDIALTSELVAPQGGVAAQVTPTRYSHVAASASLNTPALSLNEVGVFRIKATPPVATSPEGSTVSTGYFGYSIPPATSVPLGRFVPWDFNMTSGTVTPACGGFSYMSQPFGVQTVVEARNKEGSVTRNYRDAFARGALTLVAANNQDGVDRSNRLAPLAASWTEGTGKQSGQTRFMRLRELTPSLTAPEEPLPLLRLGLRVTDGETPETSFLSGRNMNPAVSGTCQSGVNCTAKQLSIPKGSDDTMIAYYGRLLASTRQGVDSAPLALPLQVQYFEGGLWRANSQDRRANSQDICTQISLAGGGIVFTDAEQRYDSATGDLILKDGTRIRLGLGNVAPGGTQVGFDAGETRFHFAPPNQAVRIPYRIVLEQQPSQPVWLADPATTGHLQGEAIFGRDRGNDRIIYRREVMP
>NZ_LS483441.1|WP_005308111.1|4214623_4215664_-|rod-shape-determining-protein
MFKKLRGVFSNDLSIDLGTANTLIYVKDQGIVLNEPSVVAIRQERGNAKSVAAVGHAAKQMLGRTPGNISAIRPMKDGVIADFYVTEKMLQHFIKQVHDNNYFRPSPRVLVCVPCGSTQVERRAIKESALGAGAREVYLIDEPMAAAIGAGLPVSEATGSMVVDIGGGTTEVAIISLNGVVYSQSVRIGGDKFDEAIISYVRRNYGSLIGEATAERIKHEIGSAYPGEEVREIEVRGRNLAEGVPRSFTLNSNEILEALQEPLSGIVSAVMVALEQSPPELASDISERGMVLTGGGALLKDIDRLLMEETGIPVVVAEDPLTCVARGGGKALELIDMHGGDLFHYE
>NZ_LS483441.1|WP_029313545.1|4213673_4214582_-|rod-shape-determining-protein-MreC
MKPIFGRGPSLQLRLFLAVIISVAAIVADSRFGVFSHVRVYLSSLVSPLQYIANAPGTLLDTMSTQVQTRADLIEQTKQQEQQLFTLRSRLLKMDQLEHENQRLRELLGSPVHKESRKMVAELLSVDSDPFSHQVLINKGALDGVYNGQPVINDQGVVGQVLHVGSTTSRVLLITDSSHGIPVRVLRNDLRAIASGSGELDKLELRNLPRNTDVQVGDLLVTSGLGGRFPEGYPVATVTRSDYVEGKPFAQIEAKPLVALDRLRYLLLLWTDKKPEVHDKDALEPAASASAATATSAAGATR
>NZ_LS483441.1|WP_042015316.1|4225728_4227441_-|type-II/IV-secretion-system-protein
MAQPRLKMRLGDLLVQEQIISDDQLQLALQQQRQTGRKLGTTLIDLGFISEVQLLTFLARQLDVPFFDLNNLTIDVSAVALLPEVQARRYRALAVNLSDDKVTVVMSDPADLSALDAIAALLSPRELVLAVAREGQLLEYFDRLYRRTREIENFAVQLHEEHQETGFELGAGSLNAATDEGEATVAKLLRSLFEDAVQVGASDIHIEPDEKVLRIRQRIDGVLHENILSEVRIAQALVLRLKLVAGLDISEKRLPQDGRFNMKVRGRDVDVRMSTMPVQYGESVVMRLLDQSSGILSLAETGMPPAILTRFRRQLKRPHGMILVTGPTGSGKTTTLYGALSELNQASHKIITVEDPVEYRLPRISQVQVNPKIGLTFSQVLRSTLRQDPDILLVGEMRDNETVEIGLRGAITGHLVLTTLHTNDAVTSALRLIDMGAPGYLVASALRAVVAQRLVRRVCEHCACETAPDEGQATWLSVLSGEAPGQHRYRKGRGCQSCNFTGYAGRIGVYELLELDQPMMDALRRNDAEGFARAARAHEHYRPLALTALDYAREGITSVDEVLRLAEDLG
>NZ_LS483441.1|WP_042015315.1|4227515_4228652_-|tetratricopeptide-repeat-protein
MSVINQMLKDLDRRQQEAEGAAVYVAPVRQQGWWMLVLTLLCTLALGILGWRTWIFWQQSQRASLPAAQVEALRTAPAAAPSAPLAVVATTQAVSSAAPVAKVPAAGAESTATRVASSAAEQVPADEAVLADEGNPQEALGDETIPSDEELQPDLYAELAAEQSAEEAPAPAAPRKPGILKIETVELSDAELATLAERKATTAMAKGRMEEAQDGYYEVLAHDPHNQGAREQLAGLLYGAGRLTEAAQVLEEGLRLDPAQADLRLLLARVAISGGDRQKALDWLTGYQPDIASNLDYYATWAGLAQELGQPVQASEMYVRLLRQQPDQGRWWLGLGVAEDGQGHRQRALDAYRNAQLHGNLGEASTQWLEQRIGQLTH
>NZ_LS483441.1|WP_042015314.1|4228648_4229539_-|AAA-family-ATPase
MYLSHFGLREAPFGLTPNTGFYYGLPPHEEAMQVLNWALSQGEGFIKVTGEVGTGKTLLCRKLLSELGSEACPVRLAWLPNPHLTPGELRTALALELGLTLAGESELDLTDRIHRHLISLHRQGSRVVVLIDEAQALPDETLEAIRLFGNLETESSKLLQIVLFGQPELDARLGQPRLRQLRQRIGFSYRLRPLRLDETRAYLEYRLQVSGYRGSALFDGRALRRLWRASRGIPRLINILAQKCLMLAYGRGVRRIDSALVRLAIRDTDDARRGRLTLWWPLLLLLGTALAYGVWS
>NZ_LS483441.1|WP_141651384.1|4229529_4229712_-|hypothetical-protein
MVSPQGLIRDDAPVEHSFSHVAAPPGCRHSALPDGGGAMSLIRGCLRLRALDSGREGACI
>NZ_LS483441.1|WP_010672620.1|4229690_4231367_-|pilus-(MSHA-type)-biogenesis-protein-MshL
MKKHPFCLLPLALAVAGCTTYRHPEPVQAKDALKQAMSEQSPTAPLTSLPPSVQSELLQLNRPQQPMTIPEKRMRIAAHDVDAVEFFGSLFKGSRYSVAVHPGVAGVISVELKDVTLQEALATVGDMYGFDVQRKGNVFHVYPAGLRTETIPVNYLMMARRGLSRTSVSTGGVTANDNNNGNNNNFDNGLNNSGNNNSQGNTASGDNNTNSNGTRIETDSNNDYWTDLRDALQTLIGTGEGRAVITSPQAGLVTVRAYPKELKAVREFLDQSGEHLKRQVVLEARILEVSLNEGYEQGVDWSGLSASWDGGKGITGGGSLMDSPIASTPNQIFRALGGGAGFTISDGNFNVAVSLLKTQGDVNTLSSPRVTATNNQKAVIKVGTDEYFVTNASTTTTTSGTSAPIVTPNVELTPFFSGIALDVTPQIDEQGKVLLHIHPSVIDTEEQSKTINVGTADPLVLPLAKSSIRESDTVVQANNGDIIVIGGLMKTDRQEIVSKVPLLGDIPWVGEAFTNRRESNRKVELVILLKPTVVEKDTWQKELQRSSELLDKWYPPKG
>NZ_LS483441.1|WP_039040513.1|4231436_4231739_-|MSHA-biogenesis-protein-MshK
MALWGSLLALQAQAEVLQDPTLPLAGSGSAASVAKEAGLPRLQSVILGSGPALAVLDGQSYRVGQQVNGFRLVGISADSVVLEKAGKRQTLTLFGSKIRM
>NZ_LS483441.1|WP_042015312.1|4231794_4232442_-|MSHA-biogenesis-protein-MshJ
MDMKAQWQGWAQQIAALSLRERILILLTGVVLLGAMGIYGWLDDADTRLGQDRLALAAAQRDLEILTLENQGKQARLGRDPDAQVREQLAGVETTLRQMDAELLAQTVDLIPAHEMPAVLEALLSRSANLHMLALTSLKPEPLMAGEQKVNLFRHGIRLQLEGGYFDVYQYLKALEALPRHFYWKGFDYRVVEHPKAAVAMEIYTLSTSKEFIRG
>NZ_LS483441.1|WP_042015309.1|4233033_4233897_-|hypothetical-protein
MKSLFRRSPSSHQVGILLASDRILLACVDPVPVFASQPVNGPHDWSKALAELFSRHGLAKSKVRVALAASLYQQIQIDKPAVPDAEMAGALPWAIKDFVNEPVLQLAMDYVDLPTPPAGRPRINVVCMSKSRVQQVADAVNGAATLEAIVSDELAMTALYEADQMVRMLLWQPRGQELQLLVFHRGGLCFSRQLRGFASLTGSHEPDADQLDALALEIQRSIDYLAGHLKLPEPGQLQLAIASSAMGVLVRHLEQTFGFPVSAMANKAVLAGVEYLSAYGAALGRSD
>NZ_LS483441.1|WP_042015307.1|4234017_4234932_+|pyridoxal-phosphate-dependent-enzyme
MAPLQLPSPLHRIRHPLLAAHDVTLWCKRDDLIHPTLSGNKWRKLKYHLQQAQMLGKGHILSFGGAYSNHIHALAAAGLRLGVRTTGIIRGEGDTVSNPTLKAAKGWGMDLVFVDRQDYRRRQDPEWLARFEDDDTLLVPEGGSSPLAIPGVAELVDEVPFSPDLWVLPCASGGTLAGLIAGKRAQEQILAIAVLKGADFITGEVCRLHPAAATTPGWRIALDHHDGGYARFSPALWQWVQAFSAETGLPLEPIYSGKAMWGLFRELAAGRIARGSKIIFIHTGGLQGLAGLQEQGRLSPRPGR
>NZ_LS483441.1|WP_042015305.1|4234928_4236848_-|RNase-E-specificity-factor-CsrD
MKLTTQLVSFITLCVISAMAMVMLGGVFSFRQMGMELQQNRVDSLVEIIDKQLGVTDDQQALARWLPSLLRASHVVELEIRQDKQRVYWFRDVQQQTDESLLIAYSEAIPNQAGMRADFKLDRPFKEFEYSMKAMFGISLGIFIVVFGLWYSIRWLRQQLRGAELLAERAQLILDGKLTKLAHDPAEEWPVSASQALTHLLTELADARKERSRFDNFIRSNAFVDKTTGIGNRLFFDNRLESAIMEASVISGGVLLIELAGLEELDPELSGRPSQELLMEASATIAAFVRKHSGALQARYAGQVFAVLLPNMSESEMVDGASQLLKSLQRLHWPEAVNADTAVYLGAVCYQAQDSLLKVQEEAELALKSARLQGHSGWFLFEKSLNEEASSKGTVRWRTLISRRIEEQGIDFYVQPVQQERDQVVLQQELLIRLHDEQGRELQAGVFMPMAEKAGLLLPLDRLVVARALRLLRQRPASSCPISLSLCAQNLLTREFQRELFFELFQLPRSTNEGLILQLSESQVTRHYEALKRPLRAMRMLGCRLAIDHAGQDVVSTQYIKEFEIHFLKLHPSLVREIHLRQVNQMAVRSLVGGCANTQARVIAVGVESGDEWKMLRHLGVHAGQGPWFADPEPLNLLD

Crispr_ID: NZ_LS483441_11

• CRISPR_ID: NZ_LS483441_11
• CRISPR_location: 4240120-4240211
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_LS483441_11

Consensus_repeat	Method
CTGTTCCTGATGTTTGAACACGGATAA	CRISPRCasFinder

spacers of NZ_LS483441_11

>11.1|4240147|38|NZ_LS483441|CRISPRCasFinder
GGCTGCCAGCACTCACCCCAGTGCTGTTCGTGGTTTAT

CRISPR arrays and Neighbor proteins around NZ_LS483441_11

CRISPR arrays

The CRISPR arrays of NZ_LS483441_11

>merge|NZ_LS483441|11|4240120-4240211|CRISPRCasFinder
CTGTTCCTGATGTTTGAACACGGATAAGGCTGCCAGCACTCACCCCAGTGCTGTTCGTGGTTTATCTGTTCCGGATGTTTGAACACGGATAA

>NZ_LS483441|11|10|4240120-4240211|CRISPRCasFinder
CTGTTCCTGATGTTTGAACACGGATAA	GGCTGCCAGCACTCACCCCAGTGCTGTTCGTGGTTTAT
CTGTTCCGGATGTTTGAACACGGATAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LS483441.1|WP_042015312.1|4231794_4232442_-|MSHA-biogenesis-protein-MshJ	unknown	unknown	gnl|CDD|377391
NZ_LS483441.1|WP_141651384.1|4229529_4229712_-|hypothetical-protein	unknown	unknown	unknown
NZ_LS483441.1|WP_042015442.1|4237361_4238897_+|EAL-domain-containing-protein	unknown	unknown	gnl|CDD|238923
NZ_LS483441.1|WP_039040413.1|4244552_4245788_-|imidazolonepropionase	unknown	unknown	gnl|CDD|236478
NZ_LS483441.1|WP_042015305.1|4234928_4236848_-|RNase-E-specificity-factor-CsrD	unknown	unknown	gnl|CDD|236833
NZ_LS483441.1|WP_042015314.1|4228648_4229539_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|132060
NZ_LS483441.1|WP_042015309.1|4233033_4233897_-|hypothetical-protein	unknown	unknown	gnl|CDD|227306
NZ_LS483441.1|WP_042015307.1|4234017_4234932_+|pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|225313
NZ_LS483441.1|WP_042015303.1|4241872_4243576_-|urocanate-hydratase	unknown	unknown	gnl|CDD|235448
NZ_LS483441.1|WP_041212197.1|4245944_4246649_-|histidine-utilization-repressor	unknown	unknown	gnl|CDD|188194
NZ_LS483441.1|WP_010672611.1|4240338_4241871_-|histidine-ammonia-lyase	unknown	unknown	gnl|CDD|236484
NZ_LS483441.1|WP_010672606.1|4246659_4247319_-|carbonate-dehydratase	unknown	unknown	gnl|CDD|238448
NZ_LS483441.1|WP_039040513.1|4231436_4231739_-|MSHA-biogenesis-protein-MshK	unknown	unknown	unknown
NZ_LS483441.1|WP_029313526.1|4247446_4248301_-|RNA-polymerase-sigma-factor-RpoH	unknown	unknown	gnl|CDD|235838
NZ_LS483441.1|WP_029313524.1|4248753_4249707_-|cell-division-protein-FtsX	unknown	unknown	gnl|CDD|182910
NZ_LS483441.1|WP_042015299.1|4250597_4252340_-|signal-recognition-particle-docking-protein-FtsY	unknown	unknown	gnl|CDD|236686
NZ_LS483441.1|WP_042015300.1|4243621_4244560_-|formimidoylglutamase	unknown	unknown	gnl|CDD|237500
NZ_LS483441.1|WP_010672603.1|4249706_4250375_-|cell-division-ATP-binding-protein-FtsE	unknown	unknown	gnl|CDD|225438
NZ_LS483441.1|WP_010672620.1|4229690_4231367_-|pilus-(MSHA-type)-biogenesis-protein-MshL	unknown	unknown	gnl|CDD|274176
NZ_LS483441.1|WP_042015315.1|4227515_4228652_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|274350

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_LS483441.1|WP_042015312.1|4231794_4232442_-|MSHA-biogenesis-protein-MshJ	gnl|CDD|377391	pfam04612, T2SSM, Type II secretion system (T2SS), protein M. This family of membrane proteins consists of Type II secretion system protein M sequences from several Gram-negative (diderm) bacteria. The precise function of these proteins is unknown, though in Vibrio cholerae, the T2SM (EpsM) protein interacts with the T2SL (EpsL) protein, and also forms homodimers.	0.00149546
NZ_LS483441.1|WP_010672603.1|4249706_4250375_-|cell-division-ATP-binding-protein-FtsE	gnl|CDD|225438	COG2884, FtsE, Predicted ATPase involved in cell division [Cell division and chromosome partitioning].	3.18206e-123
NZ_LS483441.1|WP_042015442.1|4237361_4238897_+|EAL-domain-containing-protein	gnl|CDD|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	1.55705e-82
NZ_LS483441.1|WP_039040413.1|4244552_4245788_-|imidazolonepropionase	gnl|CDD|236478	PRK09356, PRK09356, imidazolonepropionase; Validated.	0
NZ_LS483441.1|WP_042015305.1|4234928_4236848_-|RNase-E-specificity-factor-CsrD	gnl|CDD|236833	PRK11059, PRK11059, regulatory protein CsrD; Provisional.	0
NZ_LS483441.1|WP_042015314.1|4228648_4229539_-|AAA-family-ATPase	gnl|CDD|132060	TIGR03015, pepcterm_ATPase, putative secretion ATPase, PEP-CTERM locus subfamily. Members of this protein are marked as probable ATPases by the nucleotide binding P-loop motif GXXGXGKTT, a motif DEAQ similar to the DEAD/H box of helicases, and extensive homology to ATPases of MSHA-type pilus systems and to GspA proteins associated with type II protein secretion systems. [Protein fate, Protein and peptide secretion and trafficking].	1.21183e-75
NZ_LS483441.1|WP_042015309.1|4233033_4233897_-|hypothetical-protein	gnl|CDD|227306	COG4972, PilM, Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion].	0.001055
NZ_LS483441.1|WP_042015307.1|4234017_4234932_+|pyridoxal-phosphate-dependent-enzyme	gnl|CDD|225313	COG2515, Acd, 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism].	1.2457e-54
NZ_LS483441.1|WP_042015303.1|4241872_4243576_-|urocanate-hydratase	gnl|CDD|235448	PRK05414, PRK05414, urocanate hydratase; Provisional.	0
NZ_LS483441.1|WP_010672611.1|4240338_4241871_-|histidine-ammonia-lyase	gnl|CDD|236484	PRK09367, PRK09367, histidine ammonia-lyase; Provisional.	0
NZ_LS483441.1|WP_010672606.1|4246659_4247319_-|carbonate-dehydratase	gnl|CDD|238448	cd00883, beta_CA_cladeA, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	1.48009e-121
NZ_LS483441.1|WP_041212197.1|4245944_4246649_-|histidine-utilization-repressor	gnl|CDD|188194	TIGR02018, Histidine_utilization_repressor, histidine utilization repressor, proteobacterial. This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions].	5.28391e-96
NZ_LS483441.1|WP_029313526.1|4247446_4248301_-|RNA-polymerase-sigma-factor-RpoH	gnl|CDD|235838	PRK06596, PRK06596, RNA polymerase factor sigma-32; Reviewed.	0
NZ_LS483441.1|WP_029313524.1|4248753_4249707_-|cell-division-protein-FtsX	gnl|CDD|182910	PRK11026, ftsX, cell division ABC transporter subunit FtsX; Provisional.	2.90595e-77
NZ_LS483441.1|WP_042015299.1|4250597_4252340_-|signal-recognition-particle-docking-protein-FtsY	gnl|CDD|236686	PRK10416, PRK10416, signal recognition particle-docking protein FtsY; Provisional.	0
NZ_LS483441.1|WP_042015300.1|4243621_4244560_-|formimidoylglutamase	gnl|CDD|237500	PRK13776, PRK13776, formimidoylglutamase; Provisional.	0
NZ_LS483441.1|WP_010672620.1|4229690_4231367_-|pilus-(MSHA-type)-biogenesis-protein-MshL	gnl|CDD|274176	TIGR02519, related_to_type_II_protein_secretion_protein, pilus (MSHA type) biogenesis protein MshL. Members of this family are predicted secretins, that is, outer membrane pore proteins associated with delivery of proteins from periplasm to the outside of the cell. Related families include GspD of type II secretion (TIGR02517), the YscC/HrcC family from type III secretion (TIGR02516), and the PilQ secretin of type IV pilus formation (TIGR02515). Members of this family are found in gene clusters associated with MSHA (mannose-sensitive hemagglutinin) and related pili, and appear to be the secretin of this pilus system. [Cell envelope, Surface structures].	1.32081e-86
NZ_LS483441.1|WP_042015315.1|4227515_4228652_-|tetratricopeptide-repeat-protein	gnl|CDD|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	3.90348e-10

Protein sequences

>NZ_LS483441.1|WP_042015442.1|4237361_4238897_+|EAL-domain-containing-protein
MSARSPLWIPLALFCVPPLLMLLLTPLLSDKLAHHLLQTKERALLDYLQERNQLLDHDVPAQLAHFAFDCGPTDMALLRSPQYYNRHIRLAGLQLANGSGCSTLGPALPQLADAGIPASPDFHISSTAPMFDTERETLVYARRNGNLAYWVLDSSWSHELLRTPCNDCFYLEFNHKHPTQSGLFFPRGNKHIREEANPMRLLSFDPQHQVEQTLWAGEALKRYARSQIHRDGLWSAGALGALLAALYWSLRNYRRSLKGLLQRGLARREFIPFYQPIVDSRNRRVVGFEALLRWQRGRDLVSPGTFIAYAEEQGLILPMTDQLLERILADLPVLAPHQWVSVNLVAGHIEQPRLRTQLQRHGWPSPARLTFELTERDPIKHIQGAMAEIAALQERGYHFKLDDFGTGYGGFAYLQRLGIRQIKIDKMFVDTIGTDDLKRSVLDATIAFGLKSGMEMIAEGVETQEQVDYLHRHGVHLIQGYVYAKPMPLSKLKIWLMAWQEGETTSPSDPH
>NZ_LS483441.1|WP_042015305.1|4234928_4236848_-|RNase-E-specificity-factor-CsrD
MKLTTQLVSFITLCVISAMAMVMLGGVFSFRQMGMELQQNRVDSLVEIIDKQLGVTDDQQALARWLPSLLRASHVVELEIRQDKQRVYWFRDVQQQTDESLLIAYSEAIPNQAGMRADFKLDRPFKEFEYSMKAMFGISLGIFIVVFGLWYSIRWLRQQLRGAELLAERAQLILDGKLTKLAHDPAEEWPVSASQALTHLLTELADARKERSRFDNFIRSNAFVDKTTGIGNRLFFDNRLESAIMEASVISGGVLLIELAGLEELDPELSGRPSQELLMEASATIAAFVRKHSGALQARYAGQVFAVLLPNMSESEMVDGASQLLKSLQRLHWPEAVNADTAVYLGAVCYQAQDSLLKVQEEAELALKSARLQGHSGWFLFEKSLNEEASSKGTVRWRTLISRRIEEQGIDFYVQPVQQERDQVVLQQELLIRLHDEQGRELQAGVFMPMAEKAGLLLPLDRLVVARALRLLRQRPASSCPISLSLCAQNLLTREFQRELFFELFQLPRSTNEGLILQLSESQVTRHYEALKRPLRAMRMLGCRLAIDHAGQDVVSTQYIKEFEIHFLKLHPSLVREIHLRQVNQMAVRSLVGGCANTQARVIAVGVESGDEWKMLRHLGVHAGQGPWFADPEPLNLLD
>NZ_LS483441.1|WP_042015307.1|4234017_4234932_+|pyridoxal-phosphate-dependent-enzyme
MAPLQLPSPLHRIRHPLLAAHDVTLWCKRDDLIHPTLSGNKWRKLKYHLQQAQMLGKGHILSFGGAYSNHIHALAAAGLRLGVRTTGIIRGEGDTVSNPTLKAAKGWGMDLVFVDRQDYRRRQDPEWLARFEDDDTLLVPEGGSSPLAIPGVAELVDEVPFSPDLWVLPCASGGTLAGLIAGKRAQEQILAIAVLKGADFITGEVCRLHPAAATTPGWRIALDHHDGGYARFSPALWQWVQAFSAETGLPLEPIYSGKAMWGLFRELAAGRIARGSKIIFIHTGGLQGLAGLQEQGRLSPRPGR
>NZ_LS483441.1|WP_042015309.1|4233033_4233897_-|hypothetical-protein
MKSLFRRSPSSHQVGILLASDRILLACVDPVPVFASQPVNGPHDWSKALAELFSRHGLAKSKVRVALAASLYQQIQIDKPAVPDAEMAGALPWAIKDFVNEPVLQLAMDYVDLPTPPAGRPRINVVCMSKSRVQQVADAVNGAATLEAIVSDELAMTALYEADQMVRMLLWQPRGQELQLLVFHRGGLCFSRQLRGFASLTGSHEPDADQLDALALEIQRSIDYLAGHLKLPEPGQLQLAIASSAMGVLVRHLEQTFGFPVSAMANKAVLAGVEYLSAYGAALGRSD
>NZ_LS483441.1|WP_042015312.1|4231794_4232442_-|MSHA-biogenesis-protein-MshJ
MDMKAQWQGWAQQIAALSLRERILILLTGVVLLGAMGIYGWLDDADTRLGQDRLALAAAQRDLEILTLENQGKQARLGRDPDAQVREQLAGVETTLRQMDAELLAQTVDLIPAHEMPAVLEALLSRSANLHMLALTSLKPEPLMAGEQKVNLFRHGIRLQLEGGYFDVYQYLKALEALPRHFYWKGFDYRVVEHPKAAVAMEIYTLSTSKEFIRG
>NZ_LS483441.1|WP_039040513.1|4231436_4231739_-|MSHA-biogenesis-protein-MshK
MALWGSLLALQAQAEVLQDPTLPLAGSGSAASVAKEAGLPRLQSVILGSGPALAVLDGQSYRVGQQVNGFRLVGISADSVVLEKAGKRQTLTLFGSKIRM
>NZ_LS483441.1|WP_010672620.1|4229690_4231367_-|pilus-(MSHA-type)-biogenesis-protein-MshL
MKKHPFCLLPLALAVAGCTTYRHPEPVQAKDALKQAMSEQSPTAPLTSLPPSVQSELLQLNRPQQPMTIPEKRMRIAAHDVDAVEFFGSLFKGSRYSVAVHPGVAGVISVELKDVTLQEALATVGDMYGFDVQRKGNVFHVYPAGLRTETIPVNYLMMARRGLSRTSVSTGGVTANDNNNGNNNNFDNGLNNSGNNNSQGNTASGDNNTNSNGTRIETDSNNDYWTDLRDALQTLIGTGEGRAVITSPQAGLVTVRAYPKELKAVREFLDQSGEHLKRQVVLEARILEVSLNEGYEQGVDWSGLSASWDGGKGITGGGSLMDSPIASTPNQIFRALGGGAGFTISDGNFNVAVSLLKTQGDVNTLSSPRVTATNNQKAVIKVGTDEYFVTNASTTTTTSGTSAPIVTPNVELTPFFSGIALDVTPQIDEQGKVLLHIHPSVIDTEEQSKTINVGTADPLVLPLAKSSIRESDTVVQANNGDIIVIGGLMKTDRQEIVSKVPLLGDIPWVGEAFTNRRESNRKVELVILLKPTVVEKDTWQKELQRSSELLDKWYPPKG
>NZ_LS483441.1|WP_141651384.1|4229529_4229712_-|hypothetical-protein
MVSPQGLIRDDAPVEHSFSHVAAPPGCRHSALPDGGGAMSLIRGCLRLRALDSGREGACI
>NZ_LS483441.1|WP_042015314.1|4228648_4229539_-|AAA-family-ATPase
MYLSHFGLREAPFGLTPNTGFYYGLPPHEEAMQVLNWALSQGEGFIKVTGEVGTGKTLLCRKLLSELGSEACPVRLAWLPNPHLTPGELRTALALELGLTLAGESELDLTDRIHRHLISLHRQGSRVVVLIDEAQALPDETLEAIRLFGNLETESSKLLQIVLFGQPELDARLGQPRLRQLRQRIGFSYRLRPLRLDETRAYLEYRLQVSGYRGSALFDGRALRRLWRASRGIPRLINILAQKCLMLAYGRGVRRIDSALVRLAIRDTDDARRGRLTLWWPLLLLLGTALAYGVWS
>NZ_LS483441.1|WP_042015315.1|4227515_4228652_-|tetratricopeptide-repeat-protein
MSVINQMLKDLDRRQQEAEGAAVYVAPVRQQGWWMLVLTLLCTLALGILGWRTWIFWQQSQRASLPAAQVEALRTAPAAAPSAPLAVVATTQAVSSAAPVAKVPAAGAESTATRVASSAAEQVPADEAVLADEGNPQEALGDETIPSDEELQPDLYAELAAEQSAEEAPAPAAPRKPGILKIETVELSDAELATLAERKATTAMAKGRMEEAQDGYYEVLAHDPHNQGAREQLAGLLYGAGRLTEAAQVLEEGLRLDPAQADLRLLLARVAISGGDRQKALDWLTGYQPDIASNLDYYATWAGLAQELGQPVQASEMYVRLLRQQPDQGRWWLGLGVAEDGQGHRQRALDAYRNAQLHGNLGEASTQWLEQRIGQLTH
>NZ_LS483441.1|WP_010672611.1|4240338_4241871_-|histidine-ammonia-lyase
MFELNLQPGKLCLATLRRVSREPVHVSLDPAALAGIHASAAVVTKVIEQNRVVYGINTGFGLLANTRIPVEQLDELQRSIVLSHAAGIGEYMDDATVRLMMVLKVNSLARGFSGIRLTVLEALMTLINAEVYPVVPKKGSVGASGDLAPLAHMSCLLIGEGKARHKGELIDAATALKIAGLEPIALAPKEGLALLNGTQASTAFALEGLFHAEDLYAGAITIGAMSVEAALGSRRPFDARIHEVRGQRGQIDAAACYRHLLVDGSEIGMSHHNCEKVQDPYSLRCQPQVMGACLTQIRQAAEVLVCEANAVSDNPLVFAEDEEIISGGNFHAEPVAFAADNLALAIAEIGSLSERRMALLIDSRMSGLPAFLVNNGGVNSGFMIAQVTSAALASENKTLAHPASVDSLPTSANQEDHVSMATFAGRRLADMAENTRGILAVELLAAAQGLDFRAPLRSTELIELAKGRLREEVSFYDKDRYFAPDIEAAAALLGRASYNDLIPAGTLPSL
>NZ_LS483441.1|WP_042015303.1|4241872_4243576_-|urocanate-hydratase
MSVQHQDPRHDPSRVIRAPHGTQLTAKSWLTEAPLRMLMNNLDPDVAEHPQSLVVYGGIGRAARNWACYDKIVEVLTRLEDDQTLLVQSGKPVGVFQTHKDAPRVLIANSNLVPHWANWEHFNELDKKGLMMYGQMTAGSWIYIGTQGIVQGTYETFFAVANQHFNGEPKGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDETRIDFRLRTRYVDKKAHSLDEALAMIEEAKRSGTAVSVGLLGNAADVFAELVARGITPDVVTDQTSAHDPVHGYLPQGWSVAQWRDLQKSAPDEVNVAARRSMARQVEAMLTLQSRGAATLDYGNNIRQMALEEGVKNAFDFPGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYKTDQKVKELIPDDPHLHNWLDMARERIAFQGLPARICWVGVKDRVRLGLAFNEMVKNGELKAPVVIGRDHLDSGSVASPNRETESMMDGSDAVSDWPLLNALLNTAGGATWVSLHHGGGVGMGFSQHSGVVIVCDGTDDAAKRVGRVLRNDPATGVMRHADAGYEIAINCAHEAKLDLPMIDATGKGVK
>NZ_LS483441.1|WP_042015300.1|4243621_4244560_-|formimidoylglutamase
MDKFNGIDMSVWQGRQDPEDGELALRWHDRVQPWQENREPGVVLLGFACDEGVRRNKGRVGAAGAPLALRKLLANTAWHLGAPVYDGGDLACEDGDLDAAHGRLAERVASALDQGHFPLVLGGGHEVAFGSWSGLNRHLGGEGRVGIINFDAHFDLRMKQEQASSGTPFFQIAEQCAAQGTPFHYACLGVAETANTAALFARAEALGVWHVLDEAMTPTELPALLGGLDAFIARCDHLYLTIDLDVLPAAVMPGVSAPAARGVELAVIEPLIAHIRTSGKLRLADLAEYNPNLDQDNRSARVAARLVHQLTK
>NZ_LS483441.1|WP_039040413.1|4244552_4245788_-|imidazolonepropionase
MNKELLNCERVWLNVTPATLRPDLADYGLLEPHALGVRDGKIHALVPMQDLKGPYAASWQDMKGKLVTPGLIDCHTHLIFAGSRAEEFELRQKGVPYAEIARKGGGIISTVRATRAASEERLYELALPRIKSLIREGVTTVEIKSGYGLTLEDELKMLRVARRLGETQPIRVKTTLLAAHAVPPEYRDDPDSWVETICQEIIPAAAEAGLADAVDVFCEHIGFSLAQTEQVYLAADQYNLAVKGHMDQLSNLGGSTLAAHFGALSVDHLEYLDQDGIQALAHRGVVATLLPTAFYFLKETKLPPVAALRKAGVPMAVSSDINPGTAPIVSLRMAMNMACTLFGLTPVEAMAGVTRHAARALGEQERLGQLKVGMLADFLVWNCGHPAELSYLIGVDQLVSRVVNGEETLHG
>NZ_LS483441.1|WP_041212197.1|4245944_4246649_-|histidine-utilization-repressor
MAPALYLQIKQHILDGIRERHYQAGDRIPTEAALCEQFAVSRMTVNKALRELVAEGWLVRTAGSGSFVADRRTESPLLAIRNIADEIAERGSEYSARVIRLQRQAADEKVAVRLGLRVGAPTFHSLIVHQADGEPLQLEERFVDAERLPGYGEQDFTQQTPNSYLMEICPLSEMEHVVEAVLPSAGEAGLLQVRVDTPCLLLHRRTWSDGCLVSYARLLSPGSRYKLSSKTRLA
>NZ_LS483441.1|WP_010672606.1|4246659_4247319_-|carbonate-dehydratase
MKLLNDLFTNNREWAERIKAEDPNFFATLSAQQAPEYLWIGCSDSRVPANQLMGLLPGDVFVHRNVANLVVHTDFNCLSVLQYAVEVLKVKHIIVCGHYGCGGVKAAMQNQELGLIDNWLRNIKDVYFKYGEQLEAIEDEHERFDYLCELNVAEQVANVCHTTIIQNAWRKGQELAVHGWIYGIKDGLLHDLDLCISGPDQIPDVYRAWPDMRPPHRRR
>NZ_LS483441.1|WP_029313526.1|4247446_4248301_-|RNA-polymerase-sigma-factor-RpoH
MGTSLQRTMALIPQGSLEGYIQAVNSIPVLSAEEERELAMRLQQDGDLEAARQLVMSHLRFVVHVAKSYSGYGLPQADLVQEGNIGLMKAVKRFDPSVGVRLVSFAVHWIKAEIHEYVLRNWRMVKVATTKAQRKLFFNLRKSKKRLGWLNHEEVQAVAADLGVSAADVTEMEARMSNYDQAFDLVGDDEDEGGFAPVHYLEDKSSDLAANIENDNWDSHATRRLSAAMATLDERSQHIIRARWLDDESKTTLQELADTYGVSAERVRQLEKNALKKLKDAMDA
>NZ_LS483441.1|WP_029313524.1|4248753_4249707_-|cell-division-protein-FtsX
MAIVRHKQPPLRRLMMYGVDHVRQAFASLGELWRNPLASLMTLAVLGVSLALPSCFHVLLKNAEVVEGSWQTSSQISLYLRKDLPEQSILDMKQRILLYPEVESVTYMNRDEALREFREISGFGDALDYLDSNPLPPVLSVIPDPRWQNPEGAAELLAKLENEPGIEQGKLDLQWLTRLQGIMNLLRHTITGIAVLLLSAVLLIVGNTLRLNILNQRSEIEVLKLVGATDAFIHRPFLYTGIWFGVIGGMLAWWLTEVMVIWSEGVVKELAGLYNSNFRLVGMGAFDGFNLILLGALLGLIASWFSVHRHIRDIEPS
>NZ_LS483441.1|WP_010672603.1|4249706_4250375_-|cell-division-ATP-binding-protein-FtsE
MIRFDKVSKVYSGGHQALQKVSFHLRKGEMAFLTGHSGAGKSTLLKLISVMERPTDGRVFFHGDDVSHIQRSQIPYVRRQIGMIFQDHRLLMDRTVFDNVALPLVIDGYSHGDINKRVAAALDKVGLLGKERYQPRMLSGGEQQRVGIARAIVNKPPLLLADEPTGNLDPQLSMDIMRLFEEFNRFGVSVLIATHDLGLIARMRYRTLTLKAGRMYSSGEDR
>NZ_LS483441.1|WP_042015299.1|4250597_4252340_-|signal-recognition-particle-docking-protein-FtsY
MAKGLFSWLGFGRKKEEAEAVPSQAPDATPAVVESEAAAVPAPVADVAPADAPAAKPEALLSGPDEGPLVVEEPEGELEPVIVNEALISTEAQVAEEAIVAAEDRAAEEARLAAEARAAEEARVAAEARAAEEARVAAEARAAEEARVAAEARAAEEARIAAEARAAEEARIAAEARAAEEDRIAAEARAAEEARVAAEARAAEEARIAAEARAAEEARVAAEAQAAEEARVAKEAQRAEDLRLVAAMEAEAAALAALPLAAKVDDDTQEKPQREGFFARLKRSLVRTRENIGSGFFGLFSGKKIDDDLFEELETQLLTADLGVDTTTRIIEGLVQHADRKQLKDAEALYGLLKQDMGEMLAKVEQPLVIDTSKKPYVILMVGVNGVGKTTTIGKLAKQFQAEGKSVMLAAGDTFRAAAVEQLQVWGQRNNIPVIAQHTGADSASVIYDAIEAARSRGADVLIADTAGRLQNKSNLMEELKKVVRVMKKLDDAAPHEIMLTLDAGTGQNALSQAKLFSEAVGLTGITLTKLDGTAKGGVIFAVADKFQIPIRYIGVGEGIDDLRPFVANDFIEALFSREE

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_LS483441_2	2.1|518391|42|NZ_LS483441|PILER-CR	518391-518432	42	LN997803	Escherichia coli phage phi467	15121-15162	5	0.881
NZ_LS483441_2	2.1|518391|42|NZ_LS483441|PILER-CR	518391-518432	42	NZ_CP041417	Escherichia coli strain STEC711 plasmid pSTEC711_1, complete sequence	296499-296540	5	0.881
NZ_LS483441_2	2.1|518391|42|NZ_LS483441|PILER-CR	518391-518432	42	KU052038	Escherichia phage SerU-LTIIb, partial genome	1164-1205	5	0.881
NZ_LS483441_2	2.1|518391|42|NZ_LS483441|PILER-CR	518391-518432	42	KU052038	Escherichia phage SerU-LTIIb, partial genome	3070-3111	5	0.881
NZ_LS483441_2	2.1|518391|42|NZ_LS483441|PILER-CR	518391-518432	42	KY653118	Morganella phage IME1369_01, complete genome	693-734	5	0.881
NZ_LS483441_9	9.1|4206975|27|NZ_LS483441|CRISPRCasFinder	4206975-4207001	27	NC_001425	Streptomyces flavovirens plasmid pSN22 DNA, complete sequence	5970-5996	5	0.815
NZ_LS483441_9	9.1|4206975|27|NZ_LS483441|CRISPRCasFinder	4206975-4207001	27	MF403009	Agrobacterium phage Atu_ph08, complete genome	10566-10592	5	0.815
NZ_LS483441_2	2.1|518391|42|NZ_LS483441|PILER-CR	518391-518432	42	NC_049942	Escherichia phage JLK-2012, complete sequence	23524-23565	6	0.857
NZ_LS483441_2	2.1|518391|42|NZ_LS483441|PILER-CR	518391-518432	42	NZ_CP022660	Salmonella enterica subsp. enterica strain RM11060 plasmid pRM11060-2, complete sequence	52073-52114	6	0.857
NZ_LS483441_2	2.1|518391|42|NZ_LS483441|PILER-CR	518391-518432	42	NZ_CP045061	Salmonella enterica subsp. enterica serovar Muenchen strain LG26 plasmid pLG26p2, complete sequence	52079-52120	6	0.857
NZ_LS483441_2	2.1|518391|42|NZ_LS483441|PILER-CR	518391-518432	42	NZ_CP045054	Salmonella enterica subsp. enterica serovar Muenchen strain LG24 plasmid pLG24p2, complete sequence	52084-52125	6	0.857
NZ_LS483441_2	2.1|518391|42|NZ_LS483441|PILER-CR	518391-518432	42	NZ_CP045058	Salmonella enterica subsp. enterica serovar Muenchen strain LG25 plasmid pLG25p2, complete sequence	52083-52124	6	0.857
NZ_LS483441_2	2.1|518391|42|NZ_LS483441|PILER-CR	518391-518432	42	NC_021742	Serratia liquefaciens ATCC 27592 plasmid unnamed, complete sequence	35423-35464	7	0.833
NZ_LS483441_2	2.1|518391|42|NZ_LS483441|PILER-CR	518391-518432	42	NZ_LN868946	Salmonella enterica subsp. enterica serovar Senftenberg strain NCTC10384 plasmid 4, complete sequence	103821-103862	7	0.833
NZ_LS483441_2	2.1|518391|42|NZ_LS483441|PILER-CR	518391-518432	42	MH791411	UNVERIFIED: Escherichia phage Ecwhy_1, complete genome	13640-13681	7	0.833
NZ_LS483441_2	2.1|518391|42|NZ_LS483441|PILER-CR	518391-518432	42	MH494197	Escherichia phage CMSTMSU, complete genome	196767-196808	7	0.833
NZ_LS483441_2	2.1|518391|42|NZ_LS483441|PILER-CR	518391-518432	42	NZ_CP023526	Cedecea neteri strain FDAARGOS_392 plasmid unnamed, complete sequence	1927-1968	8	0.81
NZ_LS483441_2	2.2|518470|47|NZ_LS483441|PILER-CR	518470-518516	47	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	716950-716996	8	0.83
NZ_LS483441_2	2.2|518470|47|NZ_LS483441|PILER-CR	518470-518516	47	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	661369-661415	8	0.83
NZ_LS483441_2	2.2|518470|47|NZ_LS483441|PILER-CR	518470-518516	47	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	1471000-1471046	8	0.83
NZ_LS483441_2	2.2|518470|47|NZ_LS483441|PILER-CR	518470-518516	47	NZ_CP032322	Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence	1743893-1743939	9	0.809
NZ_LS483441_2	2.2|518470|47|NZ_LS483441|PILER-CR	518470-518516	47	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	1303504-1303550	9	0.809
NZ_LS483441_2	2.2|518470|47|NZ_LS483441|PILER-CR	518470-518516	47	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	1071528-1071574	9	0.809
NZ_LS483441_2	2.2|518470|47|NZ_LS483441|PILER-CR	518470-518516	47	NZ_CP022366	Azospirillum sp. TSH58 plasmid TSH58_p04, complete sequence	324059-324105	9	0.809
NZ_LS483441_2	2.2|518470|47|NZ_LS483441|PILER-CR	518470-518516	47	NZ_CP032348	Azospirillum brasilense strain MTCC4039 plasmid p4, complete sequence	76749-76795	9	0.809
NZ_LS483441_2	2.1|518391|42|NZ_LS483441|PILER-CR	518391-518432	42	NC_027364	Escherichia phage PBECO 4, complete genome	207827-207868	10	0.762
NZ_LS483441_2	2.1|518391|42|NZ_LS483441|PILER-CR	518391-518432	42	LC494302	Escherichia phage SP27 DNA, complete genome	76611-76652	10	0.762
NZ_LS483441_2	2.1|518391|42|NZ_LS483441|PILER-CR	518391-518432	42	LT603033	Escherichia phage vB_Eco_slurp01 genome assembly, chromosome: I	17117-17158	10	0.762
NZ_LS483441_2	2.2|518470|47|NZ_LS483441|PILER-CR	518470-518516	47	NZ_CP040452	Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence	192222-192268	10	0.787
NZ_LS483441_2	2.2|518470|47|NZ_LS483441|PILER-CR	518470-518516	47	NZ_CP029833	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed3, complete sequence	195512-195558	10	0.787
NZ_LS483441_2	2.2|518470|47|NZ_LS483441|PILER-CR	518470-518516	47	NZ_CP032324	Azospirillum brasilense strain MTCC4035 plasmid p3, complete sequence	444259-444305	10	0.787
NZ_LS483441_2	2.2|518470|47|NZ_LS483441|PILER-CR	518470-518516	47	NZ_CP007797	Azospirillum brasilense strain Az39 plasmid AbAZ39_p4, complete sequence	591151-591197	10	0.787
NZ_LS483441_2	2.2|518470|47|NZ_LS483441|PILER-CR	518470-518516	47	NZ_CP032343	Azospirillum brasilense strain MTCC4038 plasmid p4, complete sequence	601103-601149	10	0.787
NZ_LS483441_2	2.2|518470|47|NZ_LS483441|PILER-CR	518470-518516	47	NZ_CP012917	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p3, complete sequence	127074-127120	10	0.787
NZ_LS483441_3	3.1|1407260|34|NZ_LS483441|CRISPRCasFinder	1407260-1407293	34	NZ_CP030264	Ensifer adhaerens strain Corn53 plasmid AB, complete sequence	1310253-1310286	10	0.706
NZ_LS483441_3	3.1|1407260|34|NZ_LS483441|CRISPRCasFinder	1407260-1407293	34	NZ_CP015882	Ensifer adhaerens strain Casida A plasmid pCasidaAB, complete sequence	1152468-1152501	10	0.706
NZ_LS483441_2	2.2|518470|47|NZ_LS483441|PILER-CR	518470-518516	47	NC_016587	Azospirillum lipoferum 4B plasmid AZO_p4, complete sequence	527113-527159	11	0.766
NZ_LS483441_2	2.2|518470|47|NZ_LS483441|PILER-CR	518470-518516	47	NC_016587	Azospirillum lipoferum 4B plasmid AZO_p4, complete sequence	549587-549633	11	0.766
NZ_LS483441_2	2.2|518470|47|NZ_LS483441|PILER-CR	518470-518516	47	NC_013858	Azospirillum sp. B510 plasmid pAB510d, complete sequence	442555-442601	11	0.766
NZ_LS483441_2	2.2|518470|47|NZ_LS483441|PILER-CR	518470-518516	47	NC_013858	Azospirillum sp. B510 plasmid pAB510d, complete sequence	419987-420033	12	0.745
NZ_LS483441_2	2.2|518470|47|NZ_LS483441|PILER-CR	518470-518516	47	NZ_CP054617	Azospirillum oryzae strain KACC 14407 plasmid unnamed3, complete sequence	224329-224375	12	0.745

1. spacer 2.1|518391|42|NZ_LS483441|PILER-CR matches to LN997803 (Escherichia coli phage phi467) position: , mismatch: 5, identity: 0.881

taggtcaccagttcgattccggtagccggcaccatttgccca	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccatatgcggg	Protospacer
*************************.********* ***  .

2. spacer 2.1|518391|42|NZ_LS483441|PILER-CR matches to NZ_CP041417 (Escherichia coli strain STEC711 plasmid pSTEC711_1, complete sequence) position: , mismatch: 5, identity: 0.881

taggtcaccagttcgattccggtagccggcaccatttgccca	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccatatgcggg	Protospacer
*************************.********* ***  .

3. spacer 2.1|518391|42|NZ_LS483441|PILER-CR matches to KU052038 (Escherichia phage SerU-LTIIb, partial genome) position: , mismatch: 5, identity: 0.881

taggtcaccagttcgattccggtagccggcaccatttgccca	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccatatgcggg	Protospacer
*************************.********* ***  .

4. spacer 2.1|518391|42|NZ_LS483441|PILER-CR matches to KU052038 (Escherichia phage SerU-LTIIb, partial genome) position: , mismatch: 5, identity: 0.881

taggtcaccagttcgattccggtagccggcaccatttgccca	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccatatgcggg	Protospacer
*************************.********* ***  .

5. spacer 2.1|518391|42|NZ_LS483441|PILER-CR matches to KY653118 (Morganella phage IME1369_01, complete genome) position: , mismatch: 5, identity: 0.881

taggtcaccagttcgattccggtagccggcaccat-ttgccca	CRISPR spacer
taggtcaccagttcgactccggtagccggcaccatattaaac-	Protospacer
****************.****************** **.  * 

6. spacer 9.1|4206975|27|NZ_LS483441|CRISPRCasFinder matches to NC_001425 (Streptomyces flavovirens plasmid pSN22 DNA, complete sequence) position: , mismatch: 5, identity: 0.815

cgcactcttctgttgggcgagccggta	CRISPR spacer
ctcacgctcctgttgggcgagccgggc	Protospacer
* *** **.****************  

7. spacer 9.1|4206975|27|NZ_LS483441|CRISPRCasFinder matches to MF403009 (Agrobacterium phage Atu_ph08, complete genome) position: , mismatch: 5, identity: 0.815

cgcactcttctgttgggcgagccggta	CRISPR spacer
gcctctgatctgttgggcgagccggta	Protospacer
  * **  *******************

8. spacer 2.1|518391|42|NZ_LS483441|PILER-CR matches to NC_049942 (Escherichia phage JLK-2012, complete sequence) position: , mismatch: 6, identity: 0.857

taggtcaccagttcgattccggtagccggcaccatttgccca	CRISPR spacer
caggtcgccagttcgattccggtagccggcaccatatgcggg	Protospacer
.*****.**************************** ***  .

9. spacer 2.1|518391|42|NZ_LS483441|PILER-CR matches to NZ_CP022660 (Salmonella enterica subsp. enterica strain RM11060 plasmid pRM11060-2, complete sequence) position: , mismatch: 6, identity: 0.857

taggtcaccagttcgattccggtagccggcaccatttgccca	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccacttacgac	Protospacer
*************************.********.**.*   

10. spacer 2.1|518391|42|NZ_LS483441|PILER-CR matches to NZ_CP045061 (Salmonella enterica subsp. enterica serovar Muenchen strain LG26 plasmid pLG26p2, complete sequence) position: , mismatch: 6, identity: 0.857

taggtcaccagttcgattccggtagccggcaccatttgccca	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccacttacgac	Protospacer
*************************.********.**.*   

11. spacer 2.1|518391|42|NZ_LS483441|PILER-CR matches to NZ_CP045054 (Salmonella enterica subsp. enterica serovar Muenchen strain LG24 plasmid pLG24p2, complete sequence) position: , mismatch: 6, identity: 0.857

taggtcaccagttcgattccggtagccggcaccatttgccca	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccacttacgac	Protospacer
*************************.********.**.*   

12. spacer 2.1|518391|42|NZ_LS483441|PILER-CR matches to NZ_CP045058 (Salmonella enterica subsp. enterica serovar Muenchen strain LG25 plasmid pLG25p2, complete sequence) position: , mismatch: 6, identity: 0.857

taggtcaccagttcgattccggtagccggcaccatttgccca	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccacttacgac	Protospacer
*************************.********.**.*   

13. spacer 2.1|518391|42|NZ_LS483441|PILER-CR matches to NC_021742 (Serratia liquefaciens ATCC 27592 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.833

taggtcaccagttcgattccggtagccggcaccatttgccca	CRISPR spacer
taggtcaccagttcgattccggtagccggcaccaatcaagtc	Protospacer
********************************** *..  . 

14. spacer 2.1|518391|42|NZ_LS483441|PILER-CR matches to NZ_LN868946 (Salmonella enterica subsp. enterica serovar Senftenberg strain NCTC10384 plasmid 4, complete sequence) position: , mismatch: 7, identity: 0.833

taggtcaccagttcgattccggtagccggcaccatttgccca	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccatcaagtcc	Protospacer
*************************.*********. . .* 

15. spacer 2.1|518391|42|NZ_LS483441|PILER-CR matches to MH791411 (UNVERIFIED: Escherichia phage Ecwhy_1, complete genome) position: , mismatch: 7, identity: 0.833

taggtcaccagttcgattccggtagccggcaccatttgccca	CRISPR spacer
taggtcaccagttcgattccggtagtcggcacaaatcagccg	Protospacer
*************************.****** * *.. **.

16. spacer 2.1|518391|42|NZ_LS483441|PILER-CR matches to MH494197 (Escherichia phage CMSTMSU, complete genome) position: , mismatch: 7, identity: 0.833

taggtcaccagttcgattccggtagccggcaccatttgccca	CRISPR spacer
taggtcaccagttcgattccggtagtcggcacaaatcagccg	Protospacer
*************************.****** * *.. **.

17. spacer 2.1|518391|42|NZ_LS483441|PILER-CR matches to NZ_CP023526 (Cedecea neteri strain FDAARGOS_392 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.81

taggtcaccagttcgattccggtagccggcaccatttgccca	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccagaatgcgg	Protospacer
*************************.********     * .

18. spacer 2.2|518470|47|NZ_LS483441|PILER-CR matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 8, identity: 0.83

cgtgtcggcggttcgattccgtctctgggcaccacgaataattcctc--	CRISPR spacer
cgtgtcggcggttcgactccgtccctgggcaccac--ttcatccccctg	Protospacer
****************.******.***********   * **.**.*  

19. spacer 2.2|518470|47|NZ_LS483441|PILER-CR matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.83

cgtgtcggcggttcgattccgtctctgggcaccacgaataattcctc------	CRISPR spacer
cgtgtcggcggttcgactccgtccctgggcaccac------ttcctccccttg	Protospacer
****************.******.***********      ******      

20. spacer 2.2|518470|47|NZ_LS483441|PILER-CR matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 8, identity: 0.83

cgtgtcggcggttcgattccgtctctgggcaccacgaataattcctc------	CRISPR spacer
cgtgtcggcggttcgactccgtccctgggcaccac------ttcctccccttg	Protospacer
****************.******.***********      ******      

21. spacer 2.2|518470|47|NZ_LS483441|PILER-CR matches to NZ_CP032322 (Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.809

cgtgtcggcggttcgattccgtctctgggcaccacgaataattcctc------	CRISPR spacer
cgtgtcggcggttcgactccgtccctgggcaccac------ttcttcccctca	Protospacer
****************.******.***********      ***.**      

22. spacer 2.2|518470|47|NZ_LS483441|PILER-CR matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 9, identity: 0.809

cgtgtcggcggttcgattccgtctctgggcaccacgaataattcctc------	CRISPR spacer
cgtgtcggcggttcgactccgtccctgggcaccac------ttcttcccctca	Protospacer
****************.******.***********      ***.**      

23. spacer 2.2|518470|47|NZ_LS483441|PILER-CR matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.809

cgtgtcggcggttcgattccgtctctgggcaccacgaataattcctc------	CRISPR spacer
cgtgtcggcggttcgactccgtccctgggcaccac------ttcttcccttcg	Protospacer
****************.******.***********      ***.**      

24. spacer 2.2|518470|47|NZ_LS483441|PILER-CR matches to NZ_CP022366 (Azospirillum sp. TSH58 plasmid TSH58_p04, complete sequence) position: , mismatch: 9, identity: 0.809

cgtgtcggcggttcgattccgtctctgggcaccacgaataattcctc-----	CRISPR spacer
cgtgtcggcggttcgactccgtccctgggcaccat-----tttcctcacagc	Protospacer
****************.******.**********.      ******     

25. spacer 2.2|518470|47|NZ_LS483441|PILER-CR matches to NZ_CP032348 (Azospirillum brasilense strain MTCC4039 plasmid p4, complete sequence) position: , mismatch: 9, identity: 0.809

cgtgtcggcggttcgattccgtctctgggcaccacgaataattcctc-----	CRISPR spacer
cgtgtcggcggttcgactccgtccctgggcaccat-----tttcctcaaggt	Protospacer
****************.******.**********.      ******     

26. spacer 2.1|518391|42|NZ_LS483441|PILER-CR matches to NC_027364 (Escherichia phage PBECO 4, complete genome) position: , mismatch: 10, identity: 0.762

taggtcaccagttcgattccggtagccggcaccatttgccca	CRISPR spacer
aaggtcaccagttcgattccggtagtcggcacaaaataaagg	Protospacer
 ************************.****** *  *.   .

27. spacer 2.1|518391|42|NZ_LS483441|PILER-CR matches to LC494302 (Escherichia phage SP27 DNA, complete genome) position: , mismatch: 10, identity: 0.762

taggtcaccagttcgattccggtagccggcaccatttgccca	CRISPR spacer
aaggtcaccagttcgattccggtagtcggcacaaaataaagg	Protospacer
 ************************.****** *  *.   .

28. spacer 2.1|518391|42|NZ_LS483441|PILER-CR matches to LT603033 (Escherichia phage vB_Eco_slurp01 genome assembly, chromosome: I) position: , mismatch: 10, identity: 0.762

taggtcaccagttcgattccggtagccggcaccatttgccca	CRISPR spacer
aaggtcaccagttcgattccggtagtcggcacaaaataaagg	Protospacer
 ************************.****** *  *.   .

29. spacer 2.2|518470|47|NZ_LS483441|PILER-CR matches to NZ_CP040452 (Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence) position: , mismatch: 10, identity: 0.787

cgtgtcggcggttcgattccgtctctgggcaccac-------gaataattcctc	CRISPR spacer
cgtgtcggcggttcgattccgtctctggccaccacactgctggggta-------	Protospacer
**************************** ******       *..**       

30. spacer 2.2|518470|47|NZ_LS483441|PILER-CR matches to NZ_CP029833 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed3, complete sequence) position: , mismatch: 10, identity: 0.787

cgtgtcggcggttcgattccgtctctgggcaccacgaataattcctc--------	CRISPR spacer
cgtgtcggcggttcgactccgtccctgggcaccac--------cctcccttcgaa	Protospacer
****************.******.***********        ****        

31. spacer 2.2|518470|47|NZ_LS483441|PILER-CR matches to NZ_CP032324 (Azospirillum brasilense strain MTCC4035 plasmid p3, complete sequence) position: , mismatch: 10, identity: 0.787

cgtgtcggcggttcgattccgtctctgggcaccacgaataattcctc-----	CRISPR spacer
cgtgtcggcggttcgactccgtccctgggcaccat-----tctcctcacggt	Protospacer
****************.******.**********.      .*****     

32. spacer 2.2|518470|47|NZ_LS483441|PILER-CR matches to NZ_CP007797 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p4, complete sequence) position: , mismatch: 10, identity: 0.787

cgtgtcggcggttcgattccgtctctgggcaccacgaataattcctc-----	CRISPR spacer
cgtgtcggcggttcgactccgtccctgggcaccat-----tctcctcacggt	Protospacer
****************.******.**********.      .*****     

33. spacer 2.2|518470|47|NZ_LS483441|PILER-CR matches to NZ_CP032343 (Azospirillum brasilense strain MTCC4038 plasmid p4, complete sequence) position: , mismatch: 10, identity: 0.787

cgtgtcggcggttcgattccgtctctgggcaccacgaataattcctc-----	CRISPR spacer
cgtgtcggcggttcgactccgtccctgggcaccat-----tttccttttgcc	Protospacer
****************.******.**********.      *****.     

34. spacer 2.2|518470|47|NZ_LS483441|PILER-CR matches to NZ_CP012917 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p3, complete sequence) position: , mismatch: 10, identity: 0.787

cgtgtcggcggttcgattccgtctctgggcaccacgaataattcctc-----	CRISPR spacer
cgtgtcggcggttcgactccgtccctgggcaccat-----tttccttttgcc	Protospacer
****************.******.**********.      *****.     

35. spacer 3.1|1407260|34|NZ_LS483441|CRISPRCasFinder matches to NZ_CP030264 (Ensifer adhaerens strain Corn53 plasmid AB, complete sequence) position: , mismatch: 10, identity: 0.706

gctgccatcgcctcgacgcttgttgccattggcg	CRISPR spacer
ctcgtcatcgcatcgacgctcgttgccatgctca	Protospacer
 ..*.****** ********.********   *.

36. spacer 3.1|1407260|34|NZ_LS483441|CRISPRCasFinder matches to NZ_CP015882 (Ensifer adhaerens strain Casida A plasmid pCasidaAB, complete sequence) position: , mismatch: 10, identity: 0.706

gctgccatcgcctcgacgcttgttgccattggcg	CRISPR spacer
ctcgtcatcgcatcgacgctcgttgccatgctca	Protospacer
 ..*.****** ********.********   *.

37. spacer 2.2|518470|47|NZ_LS483441|PILER-CR matches to NC_016587 (Azospirillum lipoferum 4B plasmid AZO_p4, complete sequence) position: , mismatch: 11, identity: 0.766

cgtgtcggcggttcgattccgtctctgggcaccacgaataattcctc--------	CRISPR spacer
cgtgtcggcggttcgactccgtccctgggcacca--------ttctcttcaagca	Protospacer
****************.******.**********        *.***        

38. spacer 2.2|518470|47|NZ_LS483441|PILER-CR matches to NC_016587 (Azospirillum lipoferum 4B plasmid AZO_p4, complete sequence) position: , mismatch: 11, identity: 0.766

cgtgtcggcggttcgattccgtctctgggcaccacgaataattcctc------	CRISPR spacer
cgtgtcggcggttcgactccgtccctgggcaccat------tccctttcaagc	Protospacer
****************.******.**********.      *.***.      

39. spacer 2.2|518470|47|NZ_LS483441|PILER-CR matches to NC_013858 (Azospirillum sp. B510 plasmid pAB510d, complete sequence) position: , mismatch: 11, identity: 0.766

cgtgtcggcggttcgattccgtctctgggcaccacgaataattcctc--------	CRISPR spacer
cgtgtcggcggttcgactccgtccctgggcacca--------ttctcttcaagca	Protospacer
****************.******.**********        *.***        

40. spacer 2.2|518470|47|NZ_LS483441|PILER-CR matches to NC_013858 (Azospirillum sp. B510 plasmid pAB510d, complete sequence) position: , mismatch: 12, identity: 0.745

cgtgtcggcggttcgattccgtctctgggcaccacgaataattcctc	CRISPR spacer
cgtgtcggcggttcaattccgtccctgggcaccattctcccttctgt	Protospacer
**************.********.**********.   .  ***. .

41. spacer 2.2|518470|47|NZ_LS483441|PILER-CR matches to NZ_CP054617 (Azospirillum oryzae strain KACC 14407 plasmid unnamed3, complete sequence) position: , mismatch: 12, identity: 0.745

cgtgtcggcggttcgattccgtctctgggcaccacgaataattcctc	CRISPR spacer
cgtgtcggcggttcgactccgtccctgggcaccatcctccctccttt	Protospacer
****************.******.**********.   .  *.*.*.

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	705571 : 715540	10	uncultured_Mediterranean_phage(25.0%)	tRNA	NA
DBSCAN-SWA_2	899788 : 947853	62	Vibrio_phage(17.24%)	portal,integrase,holin,tail,capsid,terminase,head	attL 913148:913163|attR 919523:919538
DBSCAN-SWA_3	1924919 : 1932575	8	Mycoplasma_phage(33.33%)	NA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NZ_LS483441|705571:715540|DBSCAN-SWA
GATGCGAATTCTGGTCAGTAATGACGATGGGGTGCACGCCGAGGGCATTCGCGCCCTCAGCGAGGCGTTGCGTGCCTGTGGCGAGGTCGTGGTGGTGGCGCCGGATCGCAACCGCAGCGGTGCCAGCCACTCCCTGACGCTGGAAGTGCCGCTGCGGGTCATCCGCCTCGATGCGTCCAGTTTTCACGGCATCAAGAGTTATGCGGTCAAGGGGACGCCGACCGACTGCGTTCATCTGGCGGTCAACGAACTGCTGCGCCCTGAGCCCGACATGGTGGTGGCCGGTATCAATCACGGGGCCAACCTGGGGGATGACGTCATCTACTCGGGGACGGTGGCGGCCGCGACGGAAGGGCGTCATCTTGGTTTCCCCTCCATCGCCGTTTCGCTGGTGGGCAAGACTCATTTCGCCAGTGCGGCCCACTACGCCGCCCAGCTGGTGCGGGGGCTGATGGTGCATCCGTTGCCTGCGGATCAGATCCTCAACGTGAATGTGCCGGACCTGCCGCTCGAGCAGATCAAGGGGATCAGGGTGACCCGCCTTGGCAATCGCCACCGGGCGGAGTCGGTGATCCGCACCGAGGATCCCCGTGGTCAGCCGGTCTACTGGATTGGTCCCCCCGGCAACCAGCAGGATGCGGGAGAGGGAACGGACTTTGCCGCCATCGAGCAGGGTTATGTCTCCATCACTCCCCTGACCATCGACATGACGGCCTACGGCAGTCTGTCGACCCTGGGCGCGTGGCTGGATCTGCAGGGATGACGTTGTGATAGTACAGCGCCTGTTGAATCAACTGATTGCCCAGGATGTCCGCGATTTCCGCGTATTGGCGGCGATCGCGAAGGTGCCGCGCCAGCTGTTTGTGGACGAGGCCATGGCCCACAAGGCCTGGGACAATACGGCCCTGCCCATCGGCCATGGGCAGACCATCTCCCAGCCTTACATCGTGGCGCGCATGACCGAGCTGCTGATCCAGAACGATCCGGCCCATGTGCTGGAGATCGGGACGGGATCGGGCTACCAGACGGCGGTACTGGCCCACCTAGTGGAGCATGTCTACACCATGGAGCGGATCAAGTCGCTGCAGTTTCAGGCCCGGCGCAGATTGCGCCAGCTCGATCTGCACAATGTGTCGGCCAAGCACGGCAATGGGTGGCTAGGTTGGCCCAACAAGGGCCCTTTCGACGCCATTCTGGTGACGGCGGCGGCCAGTGAGGTCCCCAAGGCCCTGACCGATCAGCTGGCTGATGGTGGTCGTCTGGTGTTGCCGGTGGGTGATGGCCAGCAGACCCTGCAGCTCATCGAGCGATCGGGCTCCCAGCTCACCAGCCGGATCCTGGAGCCGGTACGTTTCGTTCCCCTGATTGACGGAGATGTCGAGTGAAGTTGTTTTCCCGCCTTTATGTTCTGGTGATGCAGTGGGCACGCCACAAGTATGCCCCCTGGTATCTGGCCATCACCGCCTTTATTGAATCCATCTTCTGGCCCATCCCGGTGGATGTGATGCTGGCGCCCATGGCGCTCGGCAAACCTCATCGCGCCTGGCACTATGCCGCGCTGGCCACTCTCTTTTCGGTGCTGGGCGCCCTGTTTGGTTATCTGCTCGGCTATGCCCTGTGGGAGCCAGTGGTGCAGCCGCTGGTGACCTCGGTTGGCTATGAGGACAAGATTGCCCTGGCCGAGCAGTGGTTCGCGCAGTGGGGCATCTGGGTTATTTTTATTGCCAGCTTCACGCCGATCCCCTACAAGGTGTTTACCGTCACGGCTGGCTTGCTTCACATGGCACTGTTGCCTTTCATCCTGACCTCGCTGATCGGTCGTGGCATGCGCTTCTTCCTGGTTGCAGGTCTGATGCGCTGGGGCGGCGAGAAGATGGAGCGCAAGCTGATGCACTATGTGGATGTGCTGGGCTGGCTCTGTATTGGTTTGGCCGTTGCGGCCTATTTCTGGTTTAGTCGTTAAGGATCCACTATGTGTTCGCGTGTTTGGCAAGGTAGCGGTGTCGTCGTGTTGTCATGGCTGCTGCTTGCCTGTTCCTCCAGCAAGACTGCGGCTCCGGTGCACAGCCTGGGCAATGATCAGGTCGCTTCGACCATCCCCGTGCGTCAAGGTATGACCAAGCCCGGCATTGCAGGCAACGGGTACACCGTGGTCAAAGGAGACACTCTCTATTCCATTGCATTTCGTTCTGGCATGGATGTGGCTTCGCTTATCAGCATCAATGGCATCACTCCCCCCTATAACATTTATCCCGGCCAGCAGCTCAGGCTCGATGGCGCTTCCGCCCCCATGGCGGTGGCAACCGTCGGCAGCCCTGTCAGTCGTGGCAGCGTGACGGGGTCTGGCAGTTACGAGGTGCGCCGTGGCGATACCTTGAGCAGCATCGGTCGCCAGTTCGGTCTCTCCAACCAGGCCTTGGCCCAGCGCAACAACCTCCAGGCTCCTTATGCATTGCACGTGGGCCAGGTGCTCAATGTAGGGGGCTCGGGTTCCTCGGGTGGTCAGATGGTGGCAGCAGCCACACCGGTGGTGACCAGCACGGGGCCCAAACCCCTGGCCACGGCTCCGGCAGGTACGACCACACCATTTATTGCTCAGAAAACGATTGCTCCTGCCTCGTCAACAGCATACGCTCAGGCGAAAGAACAAAAAACCGTCAGTTCCTCGTCAACACTCTCCTGGCATTGGCCGACCAAAGGGCGGATCGTTGAAGGCTTCTCCGTTGCGGAACAAGGCAACAAGGGCATCGACATTTCCGGCCAGAAGGGCCAACCCATTTACGCTGCGAGCAGCGGCAAAGTGGTCTATGCGGGCAGTGCACTGCGAGGGTATGGCAAGCTGATAATTCTCAAGCACAACGATGACTACCTCTCCGCCTACGCTCACAACGATGAGTTGAGGGTCAAGGAGGGAGACACCGTGAAGGGCGGAGCGGTTATCGCCAATATGGGTAGCACGGATGCGCCGGATGTGCGCTTGCACTTTGAAATCCGGTACAAAGGCAAGTCGATCAACCCGATGGGCTATTTGCCAAAGCGTTAACTCAGAGAGCTGAGTCTTACTCTGGTGTAGGTCAGGGAGAGATATCATGAGCCAAGAACAACTGGTAATGCAGGATGCAGAGTTAGAGTTCGACGAGGAGCTGGAGGTTCAGGAGGAAGAAGAGGTTCAGGAAGTGGCGGCCGAAGCCGAAGAGACCATTTCCGATGAACTGATGGCGCCAGAGCTGAACAAGGTAATGGACGCCACCCAGCTCTATCTGGGGGAGATAGGCTTCTCCCCCTTGCTCACGGCCGAAGAGGAAGTCTACTACGCCCGCCGTGCCCTGCGTGGCGACAAAGCGGCGCGCAAGCGCATGATTGAATCCAACCTGCGCCTGGTGGTCAAGATTGCCCGGCGCTACAACAACCGCGGCCTGGTGCTGCTGGATCTCATCGAAGAGGGCAACCTCGGCCTTATCCGCGCCGTCGAGAAGTTCGACCCCGAGCGAGGCTTCCGTTTCTCTACCTATGCCACCTGGTGGATCCGCCAGACCATAGAACGGGCCATCATGAACCAGACCCGTACCATTCGTCTGCCCATCCATGTGGTCAAGGAGCTGAACGTCTATCTGCGCACTGCGCGCGAGCTTTCTCATCGTCTCGACCATGAGCCGACCGCCGAGGATATCGCCTCTGCACTGGATCGCTCTGTGGACGATGTGAATCGCATGCTCAAGCTCAACGAGAAGATCACCTCGGTGGATACTCCCATTGGTGGCGATCGCGACAAGGCGCTGCTGGATGTACTTTCCGACGAGCGCGGCATGGGGCCCGAGCTGGAGTCCCAGGAAGATGACATGCGCAGCAGCATAGTGCACTGGCTGGAGGAGCTGAATCCCAAGCAGCGCGAAGTGCTGGCCCGCCGTTTCGGTCTGCTCGGCTATGAACCGGCCACCTTGGAAGACGTGGGCGCCGAGATTGGTCTGACCCGCGAGCGGGTGCGTCAGATCCAGGTAGAAGGGTTGCGCCGCTTGCGGGAGATCCTGCTGGGGCAGGGACTCTCCATCGAAGCGTTGTTCCGCACCAACTAAACGGGTATGAATACCGTCATCAAGATGAAAAAGGGGCCGCAGGCCCCTTTCTTTTTGTCGTGGATCGTCAGGATCACACCGGATCCAGGGTATCCAGCGGCCAGCGCGGCACGGCCTTGACGACCAGGGGTTCGAAGACTCCCGCCTTAAGGCGTTGCATGCCTGCATAGGCGATCATGGCGCCGTTGTCGGTGCAGTATTCGGTGCGCGGGTAGAAGACTTCACCTTTGAGGCTCTCCATCAGCTCGGCCAGCTGGGCGCGCAGATGACGGTTGGCGCTGACGCCGCCTGCCACGACCAGACGATTGAGGCCGGTCTCTTTCAGGGCACGACGGCACTTGATGGCCAGGGTGTCGACCACCGCATCCTCAAACGCCCGGGCGATGTCGGCACGGGTCTGCTCGTCGTCGCCATTGGCTGCTATGGTATTGGCGGCAAAGGTCTTGAGGCCGGAGAAGCTCATGTCGAGCCCGGGACGGTCGGTCATGGGACGCGGGAAGGTGAAGCGCCCAGTGGTGCCCTTTTCTGCCAGCCGGGAGAGCAGTGGACCACCGGGATAGTCCAGACCCATCAGCTTGGCGGTCTTGTCGAACGCCTCACCGGCGGCATCGTCGATCGATTCGCCCAGCAGCTGGTAGCTGCCGATGCCGTCGACCCGGACCAGCATGGAGTGGCCGCCGGAAACCAAGAGCGCTACGAAGGGAAACTCGGGGGCTCGCTCTTCCAGCATGGGGGCCAGCAGGTGGCCTTCCATGTGGTGTACGGCGATGGCCGGCTTGTCCCAGGCCATGGCCAGCGAGCGGCCTATGGTCGCCCCGACCAGGATGGCGCCAACCAGACCTGGCCCCGCGGTATAGGCGATGCCATCGATGTCATCCTTGCCAAGTCCGGCCTCTTTCAAGGCGGCCTGGATCAAGGGGATCGTCTTGCGTACATGGTCCCGGCTGGCGAGCTCGGGAACGACGCCGCCGTAGTCCGCATGCAGCTTGACCTGGCTGTACAACTGGTGGGAAAGGATCCCTTTTTGATCATCGAAGATCGCGATCCCGGTTTCGTCACAGGATGTCTCTATGCCCAATACACGCATTGCTAAAAAATTTCACTGCTAAAATGAGACGGCTATGGTAACCTTCGCGGGTTTTTTAAACCAGAGCGATCTCTGCGGGTTTACTTTCATTCCCTGTCCAGAGTATAATTTCGCACCATTTTAAGACATGCTGATCGATTGAAGGTCAGCTAACAATTTATCACTGAGGTGAAAGGCACATGCCAGTAATCAAAGTCCGTGAAAATGAGCCGTTTGACGTTGCTCTGCGTCGCTTCAAGCGTTCTTGCGAAAAGGCCGGTATCCTGTCCGAAGTTCGTAGCCGTGAGTTCTACGAGAAGCCGACTACCATTCGCAAGCGCGCTAAAGCGTCCGCTGTCAAGCGTCACGCCAAGAAGCTGTCCCGCGAAAACGCACGTCGTATCCGCCTGTACTAATCAAGGGATCATGCCGTGTCTCTGAAGGATCAACTCAAGGATCAGCAAAAGCTCGCGATGCTTGCCAAAGACAAGCCTCGGTTGGGTGCTATCCGCTTGTTGATGGCAGAAATCAAGCAGCGTGAAGTCGATACCCGTGTCGAGCTCAACGATGAAGAGATCCTCGCTGTCGTGACCAAAATGGTCAAACAGCGTCGCGATTCCATCAGCCAGTTTGAAGCTGCCGGTCGCCAGGATCTCGCCGACAAAGAGTCCGCCGAGATCGTTGTGCTGCAGGAGTTCCTGCCACAACAGCTGACCGCAGACGAAATTGCCGCACTGATCGAGCAAGCCATCACTGAAAGTGGTGCTGCCGTCATGGCTGACATGGGTAAAGTCATGGCTGTCTTGAAGCCAAAAATTCAGGGGCGTGCCGATGTCGGCGCCGTCAGTGCTCAGGTGAAAACCCGCTTGGCGTAACAGGCAACTCTCTTGTTTGGTCGAAGAAGCCGTGCTTCCCATTGGAATGCGCGGCTTTTTTATTTCCTATGCAATGAAACAGGACGGTTATGGCTGGCAGGATCCCGCAATCCTTTATCGATGATCTGCTCGTACGCACAGACATAGTCGAGTTGATCGACTCCCGTGTGCGGTTGAAGAAAGCCGGTAAGAACTACCAGGCTTGCTGCCCTTTTCATAACGAAAAAAGCCCCTCCTTTACCGTCAGCCAGGAGAAGCAGTTCTATCACTGTTTCGGTTGTGGTGCCCACGGCAATGCCATCGGCTTTGTCATGGAGTACGACGGCCTGGAATTCCCCGATGCCATCGAAGAGCTGGCAAGCCTGCACGGCATGCAGGTCCCCCGTGAGCAAACGGCGGGTGGATCAAGCCATAGCCAACCAGCCGTCAGCAAGGATCTGTTCGAGCTGATGAACCAGATTGCGCGCTTCTACGAGAGCAATCTCAAGAACGCGCCTCAGGCGGTGGAGTATCTGAAAGGCCGGGGCCTGACTGGCGAGGTGGTCAAGCGCTTCAACATCGGTTATGCCCCTGGGGACTGGGATCAGGTGCGTCGCCGCTTTGGCGCCAGTCGGGATCACGAACAACTGCTGATTTCGGGCGGTATGCTGATCCCCCGTGACAACGGCCCGGGCAGCTACGATCGTTTCCGCGATCGCATCATGTTTCCGATCCGGGACAAACGAGGCCGGGTCATCGGCTTCGGTGGCCGAGTGCTGGGGGATGGCACGCCCAAGTACTTGAACTCCCCGGAAACCCCCATCTTCCACAAGGGGCGAGAGCTGTTCGGCCTTTATGAGGTCAAGCAGGCACACAAGGATCCGCGCCGGATCCTGGTGGTAGAAGGTTACATGGATGTGGTGGCGCTCGGCCAGTACGACATCGACTATGCGGTGGCGGCACTGGGGACTGCGACCACCAGCGATCACATCCACACCCTGTTCCGTACCACGGCAGAGGTGGTCTGTTGCTACGACGGCGACAACGCCGGTCGGGAAGCGGCCTGGCGGGCGCTGGACAACGCGCTCTCCCACCTGCAGGACGGCCGTGAACTCAAGTTCGTCTTTTTGCCGGATGGCGAGGATCCCGACTCGCTGGTACGCCAGATCGGCAAGGAGGGGTTCGAAGCGCTGCTCGACAAGGCCCAGTCGTTTGCGGATTTCATGTTCGAACGCCTCGGGCGCGATGCGGCTCTTTCCGGTGAGGCAGGCAAGTTTGAAGTGGCCAACAAGGCCGCCGAGCTGATTCGTCGGGTGCCGGAAGGTTTCACTCGCGAGGGGTTAATTACCCGACTCTCCAGCATGATGCGTTGGGGAGAAAACAAGCAGCGGATTACCGAGCTGTTTGCCCGCAACAGCCAGCCCAAGGTGGAAGTCAACAAACCCAAGGCGACCAAACTGACGCCGATCCGCAGGGCTCTGGCCCTGATGGTGCAGTATCCGGCGATCACCGCCGAGCTGCCGGCCATGCCCGAGTTGGCCGGGCTGCGCCTGCAGGGGATCCCTTTCCTGCTGCAACTGCACCAGCAGATCCTGATCCAGCCGGGAGTGACAACGGGTATCCTGCTGGAGCATTGGCGTGGCACAAAAGAGGGAGAAATACTTGCCCAACTGGCGATGCATGACCTGTTTGAAGAGGTAAAGCTCGACCAGGAGCCCGATATTCTGGGAGAATTGCAGGATACCTTTGTCGGTTTCATCAACCTTTTCCTGAAGCAACGGATCGAAGAATTGCAGGCCAAGGTGGCGCAGGAAGGGCTAAGCTCTGAGGAAACTCAGGAGCTGATGATGCTGATCAGAGAGGTGCAGATTGAGAAAAGAAATGAGAGTGGGGCTTGATATTTGAGTGAGCAGTCCCAATATGAATAGCGTTGCCCGAATAGACGGGATTGAAAGCAAACACTTTATAACCACCTGGCCCCGACAACACTGCGGGCAGGGGTTTCTCATGACCGACGCCGCAACCAGACATAGCATGTCTGGCGGTTTTCTATTAGAATTGGCTATTTGCGCAGCAGCGCACTGTACGCGCAACCTAGCAACACCAACCGGATGAGTTCTATGGAGCAAACCCCGCAGTCTCAGCTTAAACTCCTCGTTGCCAAAGGTAAAGAACAGGGCTACCTGACCTATGCCGAGGTGAACGATCACCTCCCGCAAGACATTGTCGATTCAGACCAGATCGAAGACATCATTCAGATGATCAACGATATGGGCATTCAAGTGGTTGAAAACGCTCCGGATGCCGATGACCTTATCATGGCTGAAGGTGGTACCGCCGATGAGGACGCTGCCGAAGCAGCGGCCCAGGCTCTGGCATCTGTTGAATCTGAGATTGGTCGCACGACCGATCCCGTCCGCATGTACATGCGGGAAATGGGTACCGTCGAACTGCTGACCCGCGAAGGCGAAATCGACATCGCCAAGCGGATTGAAGACGGTATCAACCAGGTACAAAGCTCCGTCGCCGAGTACCCTGAAGCCATCACCTATCTGCTCGAACAGTATGACAAGTACGAAGCCGAGCAGCTTCGTCTGTCCGACATCATCTCCGGCTTCATCGATCCGAACGAAGTGGATGACGTGGCACCGACCGCCACTCATATCGGCTCCGAGCTCAGCGAGGACGACCTCGCCGACGAAGACGAAGACGAAGATGAGGACGAAGACGAAGACGGTGACAACTCCGACGATGATGGCGACGGTGGTCCGGATCCGGAAGTCGCTCGCGAGAAATTCGGCGAACTGCGTGCCCAGTACGAGGTGACTCGTCTCTCCATTCAGCAGAATGGCCGTGCCCACGACGACACCCAGAATGCCATCGCCCAGCTGGCCGATGTCTTCCGTCAATTCCGCCTGATGCCCAAGCAGTTCGATCGCCTGGTCAACAACATGCGGGAGATGATGGAGCGTGTCCGCGTGCAGGAACGCATCATCATGAAGCTCTGCGTTGAGCAGGCCAAGATGCCGAAGAAGACCTTCGTTGCGGCCTTCACCAACAACGAGTGCGAAACTGCCTGGTTTGAATACCAGAAGCAGGCCGGCAAGGCGTGGTCTCCCCGCCTGCTCGAGATGGACGAAGAAGTCCTGCGTTCCATCGGCAAGCTGCAGCAGATCGAAGAAGAGACCGGTCTGTCGATTGCCCAGATCAAGGATATCAACCGCCGCATGAGCATTGGTGAGGCCAAAGCCCGCCGTGCGAAGAAAGAGATGGTTGAGGCTAACTTGCGTCTGGTTATCTCCATCGCCAAGAAGTATACCAACCGTGGTCTGCAGTTCCTGGATCTGATCCAGGAGGGCAACATCGGTCTGATGAAGGCGGTCGACAAGTTCGAATATCGTCGCGGCTACAAGTTCTCGACCTATGCCACCTGGTGGATCCGTCAGGCCATTACCCGCTCCATCGCGGATCAGGCCCGTACCATCCGTATCCCGGTGCACATGATCGAGACCATCAACAAGCTCAACCGTATCTCCCGCCAGATGCTGCAGGAGATGGGTCGTGAACCGAACCCGGAAGAGCTGGCCATGCGCATGGGTATGCCGGAAGACAAGATCCGCAAGGTACTGAAAATCGCCAAGGAGCCCATCTCCATGGAGACGCCCATCGGTGATGACGAAGACTCCCACTTGGGCGACTTCATCGAAGATACCACCCTGGCTCTGCCAGCGGATGCGGCCACCAGCGAGAGCCTGCGCAACGCGACCCGTGAAGTGCTGGCCGGTCTGACCGCACGGGAAGCCAAGGTACTGCGCATGCGCTTCGGTATCGACATGAACACCGACCACACCCTCGAGGAAGTGGGCAAGCAGTTCGACGTCACTCGTGAGCGTATCCGTCAGATCGAAGCCAAGGCCCTGCGCAAATTGCGCCATCCGAGCCGCTCGGAAGTGCTGCGCAGCTTCCTGGACGAGTAG

Protein sequences of DBSCAN-SWA_1

>NZ_LS483441|705571:715540|708659_709643_+|WP_010675620.1|DBSCAN-SWA
MSQEQLVMQDAELEFDEELEVQEEEEVQEVAAEAEETISDELMAPELNKVMDATQLYLGEIGFSPLLTAEEEVYYARRALRGDKAARKRMIESNLRLVVKIARRYNNRGLVLLDLIEEGNLGLIRAVEKFDPERGFRFSTYATWWIRQTIERAIMNQTRTIRLPIHVVKELNVYLRTARELSHRLDHEPTAEDIASALDRSVDDVNRMLKLNEKITSVDTPIGGDRDKALLDVLSDERGMGPELESQEDDMRSSIVHWLEELNPKQREVLARRFGLLGYEPATLEDVGAEIGLTRERVRQIQVEGLRRLREILLGQGLSIEALFRTN
>NZ_LS483441|705571:715540|705571_706333_+|WP_039041045.1|DBSCAN-SWA
MRILVSNDDGVHAEGIRALSEALRACGEVVVVAPDRNRSGASHSLTLEVPLRVIRLDASSFHGIKSYAVKGTPTDCVHLAVNELLRPEPDMVVAGINHGANLGDDVIYSGTVAAATEGRHLGFPSIAVSLVGKTHFASAAHYAAQLVRGLMVHPLPADQILNVNVPDLPLEQIKGIRVTRLGNRHRAESVIRTEDPRGQPVYWIGPPGNQQDAGEGTDFAAIEQGYVSITPLTIDMTAYGSLSTLGAWLDLQG
>NZ_LS483441|705571:715540|711140_711584_+|WP_010675618.1|DBSCAN-SWA
MSLKDQLKDQQKLAMLAKDKPRLGAIRLLMAEIKQREVDTRVELNDEEILAVVTKMVKQRRDSISQFEAAGRQDLADKESAEIVVLQEFLPQQLTADEIAALIEQAITESGAAVMADMGKVMAVLKPKIQGRADVGAVSAQVKTRLA
>NZ_LS483441|705571:715540|713674_715540_+|WP_080560569.1|DBSCAN-SWA
MSSMEQTPQSQLKLLVAKGKEQGYLTYAEVNDHLPQDIVDSDQIEDIIQMINDMGIQVVENAPDADDLIMAEGGTADEDAAEAAAQALASVESEIGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQSSVAEYPEAITYLLEQYDKYEAEQLRLSDIISGFIDPNEVDDVAPTATHIGSELSEDDLADEDEDEDEDEDEDGDNSDDDGDGGPDPEVAREKFGELRAQYEVTRLSIQQNGRAHDDTQNAIAQLADVFRQFRLMPKQFDRLVNNMREMMERVRVQERIIMKLCVEQAKMPKKTFVAAFTNNECETAWFEYQKQAGKAWSPRLLEMDEEVLRSIGKLQQIEEETGLSIAQIKDINRRMSIGEAKARRAKKEMVEANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINKLNRISRQMLQEMGREPNPEELAMRMGMPEDKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLALPADAATSESLRNATREVLAGLTAREAKVLRMRFGIDMNTDHTLEEVGKQFDVTRERIRQIEAKALRKLRHPSRSEVLRSFLDE
>NZ_LS483441|705571:715540|706337_706955_+|WP_010675623.1|DBSCAN-SWA
MIVQRLLNQLIAQDVRDFRVLAAIAKVPRQLFVDEAMAHKAWDNTALPIGHGQTISQPYIVARMTELLIQNDPAHVLEIGTGSGYQTAVLAHLVEHVYTMERIKSLQFQARRRLRQLDLHNVSAKHGNGWLGWPNKGPFDAILVTAAASEVPKALTDQLADGGRLVLPVGDGQQTLQLIERSGSQLTSRILEPVRFVPLIDGDVE
>NZ_LS483441|705571:715540|710909_711125_+|WP_005309452.1|DBSCAN-SWA
MPVIKVRENEPFDVALRRFKRSCEKAGILSEVRSREFYEKPTTIRKRAKASAVKRHAKKLSRENARRIRLY
>NZ_LS483441|705571:715540|709716_710730_-|WP_010675619.1|tRNA|DBSCAN-SWA
MRVLGIETSCDETGIAIFDDQKGILSHQLYSQVKLHADYGGVVPELASRDHVRKTIPLIQAALKEAGLGKDDIDGIAYTAGPGLVGAILVGATIGRSLAMAWDKPAIAVHHMEGHLLAPMLEERAPEFPFVALLVSGGHSMLVRVDGIGSYQLLGESIDDAAGEAFDKTAKLMGLDYPGGPLLSRLAEKGTTGRFTFPRPMTDRPGLDMSFSGLKTFAANTIAANGDDEQTRADIARAFEDAVVDTLAIKCRRALKETGLNRLVVAGGVSANRHLRAQLAELMESLKGEVFYPRTEYCTDNGAMIAYAGMQRLKAGVFEPLVVKAVPRWPLDTLDPV
>NZ_LS483441|705571:715540|711673_713461_+|WP_042016233.1|DBSCAN-SWA
MAGRIPQSFIDDLLVRTDIVELIDSRVRLKKAGKNYQACCPFHNEKSPSFTVSQEKQFYHCFGCGAHGNAIGFVMEYDGLEFPDAIEELASLHGMQVPREQTAGGSSHSQPAVSKDLFELMNQIARFYESNLKNAPQAVEYLKGRGLTGEVVKRFNIGYAPGDWDQVRRRFGASRDHEQLLISGGMLIPRDNGPGSYDRFRDRIMFPIRDKRGRVIGFGGRVLGDGTPKYLNSPETPIFHKGRELFGLYEVKQAHKDPRRILVVEGYMDVVALGQYDIDYAVAALGTATTSDHIHTLFRTTAEVVCCYDGDNAGREAAWRALDNALSHLQDGRELKFVFLPDGEDPDSLVRQIGKEGFEALLDKAQSFADFMFERLGRDAALSGEAGKFEVANKAAELIRRVPEGFTREGLITRLSSMMRWGENKQRITELFARNSQPKVEVNKPKATKLTPIRRALALMVQYPAITAELPAMPELAGLRLQGIPFLLQLHQQILIQPGVTTGILLEHWRGTKEGEILAQLAMHDLFEEVKLDQEPDILGELQDTFVGFINLFLKQRIEELQAKVAQEGLSSEETQELMMLIREVQIEKRNESGA
>NZ_LS483441|705571:715540|707542_708613_+|WP_042016232.1|DBSCAN-SWA
MCSRVWQGSGVVVLSWLLLACSSSKTAAPVHSLGNDQVASTIPVRQGMTKPGIAGNGYTVVKGDTLYSIAFRSGMDVASLISINGITPPYNIYPGQQLRLDGASAPMAVATVGSPVSRGSVTGSGSYEVRRGDTLSSIGRQFGLSNQALAQRNNLQAPYALHVGQVLNVGGSGSSGGQMVAAATPVVTSTGPKPLATAPAGTTTPFIAQKTIAPASSTAYAQAKEQKTVSSSSTLSWHWPTKGRIVEGFSVAEQGNKGIDISGQKGQPIYAASSGKVVYAGSALRGYGKLIILKHNDDYLSAYAHNDELRVKEGDTVKGGAVIANMGSTDAPDVRLHFEIRYKGKSINPMGYLPKR
>NZ_LS483441|705571:715540|706951_707533_+|WP_010675622.1|DBSCAN-SWA
MKLFSRLYVLVMQWARHKYAPWYLAITAFIESIFWPIPVDVMLAPMALGKPHRAWHYAALATLFSVLGALFGYLLGYALWEPVVQPLVTSVGYEDKIALAEQWFAQWGIWVIFIASFTPIPYKVFTVTAGLLHMALLPFILTSLIGRGMRFFLVAGLMRWGGEKMERKLMHYVDVLGWLCIGLAVAAYFWFSR

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_039041045.1|705571_706333_+	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	6.2e-69	52.6
WP_010675623.1|706337_706955_+	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	5.3e-34	45.4
WP_010675622.1|706951_707533_+	DedA family protein	NA	NA	NA	NA
WP_042016232.1|707542_708613_+	LysM peptidoglycan-binding domain-containing protein	I2E8W3	Clostridium_phage	1.7e-11	34.9
WP_010675620.1|708659_709643_+	RNA polymerase sigma factor RpoS	F4YCU2	Synechococcus_phage	3.8e-34	33.7
WP_010675619.1|709716_710730_-|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	2.6e-107	58.0
WP_005309452.1|710909_711125_+	30S ribosomal protein S21	NA	NA	NA	NA
WP_010675618.1|711140_711584_+	GatB/YqeY domain-containing protein	A0A292GL36	Xanthomonas_phage	1.3e-26	47.9
WP_042016233.1|711673_713461_+	DNA primase	A0A0K1LMQ9	Caulobacter_phage	1.2e-73	41.1
WP_080560569.1|713674_715540_+	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	1.1e-34	32.6

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NZ_LS483441|899788:947853|DBSCAN-SWA
TATGTCTGCTTACGGCACTTTCCCGACTTTTCAAAACGTAACCCATCTAGGTCAGAACAACGGTCAAGGCGATACCCGAGCCCTCTTCATGAAGCTGTTCGCTGGTGAAGTCCTGACGATGTTCCGCAATCAATGCGTCTCCTTGGGCACCACCCGAGTGATGACCCTGAAGGGCGGCAAAGCATTCGATTTCCCTGTACTTGGCATGAGCCACAATGCGAAGTACCACAAGCCCGGCGAACTGATCCGAGCTGGCGGCATCAAGAACGTCCTGCGCACTGTCACCGTCGATGACGTCGCCGTGGCTGCTGTGTTCGTGGCAGAACAAGACGAAGACCTGAGCAGCTTTGAGGTTCGATCTCACTATGCCCGTGAGCTGGCCTATGAGCTGTCGAACATGATCGACAAGAACGTCTTCCGGACCATCGCAAACGCTGCCTTCATTACCAACAAAGAGCTGGCTATCGCTCGCTTCGGTGAGAACGGCGTACTGGAGGACGAGACCTTCACCGACAACATTACCCTGCGAGCAACCGATGCGGCAGGCCGTCCGATGACCCGTGGTCAGCAAATCGTGGACGCCATCTTCCGTGCCCGTACCGAGTTCCGTAAGGCAAGCGTCCCAGGTATCCCTGTGTGTGTCCTGAAGCCGGACGACTACGAGGCCCTGACCAATGCAGCAGGCGACCTTGGCAACATGGCATGGCTGGATAAACGCTTCTTGGGTCAGACTGGCGAGGACAAGTCCAACGGTAACGCTGACACCGGCCTTCGCATTGCCGGTATGAAGATCTTCGAGTCCAACAACCTGCCGGACCAAGACGAAAGCAACGGACTGATCGGCTCACCGGAACCCCTGAGCGTGGAAGAAGGTGGCTCTGGCCGTACCGCTGCGTACCGTGGGAACTTCTCCAAGCTGCTGGGCTTGGTCTACACGAAGGACTGCGCGGCTACCGTGAAGGTACGCGACATTGCGACCAAGTGGGTCCCCGAGCCCCTGCGCGTCGGTAACACCGTGCTGGCTAAGATGTTCGTCGGTCACAACATCCTGCGTCCGGCCTGTGCGGTCGCTCTGCTGGAAGCGTAAGGGGATTTCCCTGACCAAAGGATGGAGAGAGGTTCCTGTCAGGGTCCTCTCTTCCTCTGCTGCCTTACTCGAAACCGATGGTCATGGTTGTGTTTCCTTAGACCCCCATGCGTAGCTCCTGTGTTCTTCACGGGGGCTGCCCTTGGGGGTTCTTTTTTGAATAACGTTACTCTGACCTATTACTTCCCAACTTCAAGGAGACCTTATGTCTACTCAAACTCAACACCCGAATCTGCAACGAAAGAAGCCGCAAGCCCGTACCACTGCAATCCTGTGGGAAGACGTTATCCCGAAGGCTGACGCTCTGACCCTCCACTTCTCCAAACAGGCAGGCTTTGCCCTGACCCGCACCCAGATGCTCAACGCACTGGTTAACCGCGAGTTCGACAAGCTGCGCTCTCAAGGTGAACTGGCTGGGGAGGTGCAGTGATGGACTACCAGACCGCCGACTACGGCTTCAGCGTGGAGACCTGCGACCTGCCCTCCTACTCCAGCGGCGTGAACGACCAAGGGGAAGCCCTCTATGAACTGGATGGGATCGAAATGACCAAGGCACAGGCCGAGGACTTCAAGGACTACTTCTTCGACGACGAGGACGATCACGCGCTCTCCCAGGACAACGACACCGAGTCCCTACCGGACGCCATTCTTTCAGGCTTGAACGCTGTGAATGACGCGCTGGGAGGCGGTGGAGTCGCTGAGTTCTACGCTGACGAGCTGCTGGGTCTAGGCGAAAGCCGAATGGACTCTGTGGTCTCTTCTTCCGGTATGAGTCGGGAGGAAATCCAGTCCCATGCAACAGCGGTAATGATCGACATGGCCGCACAGGTAGGAATGCCCAGCGACTACCTGATGAACGAGCTTCAGAACGACATCAACCGCGTCCGCTCGTTTAACTCCCAGTCTGGCTTGAAGCTGCTGCGAGAGGCTATCGCTGACGGTATCGCTGGGGAATACGACTCCGCGATGACCAAATGGGATCGCCTGCGTCGCGCCCTGCAATCCGTCAAATAACCCACTTTCTCTAACCCCTAGTTACCCCATACCACAGCCATCCGGAAAGCCTCTGCGGCCTTCTGGAGGGGCCACTGTGCCCGTCTCAACACACACATAAGGAAACCGACATGAACAAAATCACCATTGCTGACCTGTCCGAAGAACTGCTGGACGTAATCAACGGCCAACGCGCCCTTATCAACGAACTGGCCGAACGTGCAGGGCTGACCTCTGCGCAAGTCCAAACGATTCAGATGGACGCCTCCCAACGACACCAGCGAGCCAAAGTGGCAGCAGCAAAGGCCAAGGCCAACCGTGAAGCCTACGAAGAAGACTCCCGCCAGATGGCCGCTTGGGTCTACGCCACCCGCTTCGACTTCAACAATGCGAAGGAATGGGGCAAAGCAGCAGCGACCGAGTGGCTGGTTATCTGTGACCGTAGCGGCTCCGAGCATGGCCGTGATCACACCTTTAAGTACCACGAGCCGACCCAAGACGAACTGCTGGAAGCCCTGAAGGATCTGGGGCGGTGGAGTCGTGCGACTGAAGAACACAACAAGGACCGCCGCGAACATGCCCAGCGGACCCTTCCGAAGGTCAAGGCCAAGCTGGCCGCCCTGCTGACCGCTTAATGCAACCCACAGGGGAGGCCCAGCGTCTCCCCTGCTCTACCGAAGGAACCTATCAACATGACCGCTAATGAAACCTTTCTTGTCCATCCCAGCGACTTCGTGAAGCGCCTTCAAGCCTTCGCCACTCTGAGCCTTGGCCGCCGTCCGTCTACTGGTCAGGTGCAGAACGCAATCAACCGGTACGTCATGCAATCCCACGGGACAGACCAAGAGTCGATGCTTGCGCTTGTCCGTGAGCTGTTCCCGACAGCCGAACAGGAGGCCGCCTGATGATCACCAAACGCAAGATCACCATTGAGGACTGGAGCCACATACGCAAAGCCAAAGTCCGTCATGCCCTCTTCTGCGTGGCCTATCGGAGGCTCCAAGGGGACAGTTTCAGGACTGCCTGTCGGACTACCGCAAAGCGTCTGAAGCTCCATGAACCGACCCTGCGTCTTCTCGCAAGGCGTTACATCAAGACCACCGGAGACAACACCAAATGACCCAACCGTACACCTACACACTCGCCACTGATGGCGCTTGCAACACCAACCACACCAAAGCGTCAGTCCGTGTGGCTGGCTGGGGCTTCCTTGCTGTCCGTAGCGATGGCCGCAAAGTTGAACGCTGCGGCTACTGCGTGGGCGCTGGGGAGTCCAACCAGACCGGAGAACTGGAAGCAGTCATTCAAGGGCTGTCACTCCTTAAACCTGGCTCTGTCGTCGAGGTCCTGACGGACTCCGCCTATGTGATCAATGGGGCGACCCAGTGGTTAGCCGGATGGAAGGCGAAGGGCTGGAAGAGGGCCGACAACAAGCCAGTCCAGAACAGGGACCGCTGGGAACAGTTGGATGACCTGCTGAACACCCGCCAAGTGACCTTCAAGAAAGTGAAGGGACACAGCGGCCACCCGATGAACGAACGAGCGGATCAACTGGCCGTGACCGGTATGAATCGCGCTGGAATGTAAAACCGATCAACACACTCAACTATGTGCACTCCTACGTGAAATTTCAGGAAGAGACAGGGGGATTGACCCCGAGATTTCACGCAGCGATGCCTCCCCAAGGTCACTTCTCCCTGACCTAAGCAATACATCCGGTCACTCCCCGACCGTCAATCAACCAATTGCGTCTTTATGTCGTGCTTCTTCTGCTGCTCCAGCTTGCCTATGGGTTAAGCGATTGGGGGCTTGCTGGAGGGGGAACGGCATGAGAGGCACAACATAAGGAACCCATTCAATGAAACAAGTCGAATCTATCTCCCTGCACTTCATGGGCAACACGGTGACCGTCAACCAGAAGGACGGCTTGTTCTGTCTCAACGACCTGCACCGTGCGTACACTGGTGGTATGAGCCGTAAACAGAAGCCGCACGACTGGTGCAAAGGGATTCTTAATGGCGAGAAAAGTCGCCATTACAATTTGACCACCTTCAAGGGCAAGCACGGCGGCACCTATGCGAATGAGCAAGGGGTCTATGCCTACGCTTCATGGCTAGACGATGATTTCCACAACGCTGTCCTCCAGACCTTCTCCTCTGCTGCCCGTGGTGATGCTGAAGGGGCTGTGAAGATCGCTCAATCCTCTGTCACTCTGACATGGCGTGAAACCCTTCGTGAAGGCAATAAGGCTTTCTGTCACGCTATCTACACTGCACAAAAAGAAGGGAACGTGAAAGGCAACCTGAACCACGTCATGGCTAACATACAGTCTCTTGTCTGCAAGGCAGTGACTGGTCTGGACGGTACGGCATTCAAGAAGCGCTATGGTATGTCCGCGCGTGACTTCTTGGTGTCTCAAGATGATGGCAAGCGGCTTGGAGTGATGGCCCGCATTGAAGGCAAGGTGGAAGCGCTGCTGGAAGCGGGGATGGACTACATGATGATCAAAACAGCCCTTGCTAAAGATGTTATGAAGGCAATCGAAAGCTGGAAGTATGATGATCTTACTGTAAGCAATGGATGATGAGTGGCCAATGCAAGCGATTAGTGTTAATCAGCATGATTAACTCATTCTCGATGAGTGAACCGCGAAGATGATTACTCCATTGAATTTTGTCACTCAAGCTATTCATGAGAAAAAGGGAACCTTGCGGTTCCCTCTTCATCATTACTTGCCGCCGATCTTAAACCGGAAACATTCTGCCGTCTTAGGGTATACATACTCACCACTGCGCCAATGCTTGAAGCGCTTGCAGTAGACGTAGCCATCTTCTACGTAAGGGTATGTTTTATCGCTCATTGTAGCATTCCTCATGTCCAGAACTACTCATAGAACACCACAAGCAAAGCTGATGGTTTCTACATTGGCACACAGGGTTAGTTGCGACTTTGTCGAACTTAAACCTGTTTTTTAAAGCACCTGCGTTCAGCATCTTTGCCTCCCATAATGCAGGTGAACCAATTGAGTAGGATTGATTTCCAGGCGTTGACGGCATACTATCCAAGTCGAAAGTAACTGTGGGTTGTAGCCACTCCAGCATTGCAGTGCTGGTCAACGTGGTTCAATCTTACTCTCCTCAGAAGGCACCCCAACGGGTGCCTTTTGTCTTTCTAGAGCTCCTCTTCTTCCGAATCGACGAGGTCTAGCTGAAAGGTCAAGCAACCATCTTTGAACTCAATCAAATCATCTTTGTGCAGATACTTGACTCGACAGAACTGCTTGCGCGCTACCTTGCTCTCTTGAGTTAAGAAATCAGGCAATCCAGGGCGAAAAGAAAGTCGAATGATTGCAGGAGATGCCTCACTCTTCTTCGACTGCTGGCTCAAAGTAACGCAGCCTGGCTTATCCGATTTCTGAATGCGACAAACAGTGTTATCGCTGGCAAAGAGAATTTGTACTTTGTCCTGATACTGGAAGTTGCACTGCCCCATCACTTCGCTACTAATTCTAAAGAGCAACTCATTTTTCTTTGTCTTGAAGCTGTGGGTGATGCTGACCGGCTCAGATGTCGATTTGCCAGTTGTTGTCACGGCCTTAAATTTTAGGTTGTCGAACATAGGGCCTCCCTCTGTTGAGCTATGTGTACAATCCTACCCCCACTCAACAGGAAGATCAACACCGATCATTGCTTTGAAATCCAAAATCACGAAAATGTTTTTTAATTTGCGTTTTACAAACCAGTTTTTCCATTTTAAAAAAATAAGCGCAACTCATTACAACCAAAGACTCACCCCATCTCTCATCTCATGTTGCGATTAGCAACGTAATCACTTTTATTAAAAAATGAGTCAGTGATCATTGGCACATGCAAATTGGATAGCCTTCAGTCATTGGATAAGCGCGCTGGCGCCGGCAACATCATGTATTGGAGCGTTAACGACAAAGCCCCCTTGGCGGACTTCAGGACTGCCTGGGGTTCACCGAGGGGGCTTTTTATCGAGGTGGTTACTTATCGAACAACTTGAGGAACTGGGACATGTTTTCCTCTGCCAGCATCTTCTCGACAGCTTCAAGCTGATGGGCATAGTTGTAGCCGGAAGAGTAGAGCCCGTAGGACAACGTTAAGCCTTGCTTGCTGTGCCCGACGATCTGTGAGGTCATTCCCTCTTGTATCCCTGCGTTTTGGTAGGCGGTGATCGCCATTCCACGGAAGCTATGGAAGCACTGTCGCTTCTCTCGCTCGCCCGTTATCTTCCCTTTGAAAACACTGAATTTCGAAGACCACCCTGAAGGCGACGTTTTGCCGTGCCGGTCTAGCCATAGGCCGGAGCAGACGTGCCCTTTAAGCTCTTCCCAAAGGTATCGCGGCAGAGGGATCCCACGGACAGCATTGGCCGTCTTACCGTCTTTTATCCGTATGAGCGTAATGTTGCCCTTCACCTCGAAGTCTTCTGGAGTAAGAGAGACCAGCTCTCCAATACGGCATCCCGTCACCAGTCCGAACTTTATAAGCTGGTGCAAGGGGAGGGAGGCGGTCTCAGCCATGACCTTGAGCTGTTCGAAGGTAAATGGCTTGTACTTCTGTGGGGCTATTCCAGACTTGAAACGAGCGGCAATGAATGGGTTCGTCCCATCCACTTCTTTGTGCAGATAGCACCACTCCCAGCAGGAGGACAAGGCAGAGCGGTAGCCCTTGCGTGTCCAGTCGCTTTTCTCTGTGCTGATCGCCTGGAGCCACCTTGTGACGTCGCGAGGCTCGATCTGGGACAGATCAATGTCCTTCACCTTCAAGATGCTCAGAAGGCTTTTTGCTCCCTGACGTGCTTTGCTGATAACCGCCTTGTTGACGGAGTGGCTGTGCTCATTGGCAAACCCATCGACTGCTTCGAGCAGGGTCATTGCATAGTCTTGGGCGAGTGAGCTGTCACCGTGCAAGGCCACCCTGATTGCGTCGGCCTTCACGAGGTCCCCTGATGCGACTGCTGCTTCCACGTCATACGCATGGAAGAGGTGTTCGTCGTCATCATTAGGGCTGCTGTAGCGGTTGCTTTCTTCGACGGCTGCACGGATCTCGGCAAGGAGGTGATTGAAGCGGTGGCGGCGAGGTGCTGCCCTGACACGCTCTAGCAGCTCATTGAACTCTGCCACGATTGCATCACGCATTCGGCGGGCTTGCTGCAGGTCGCTGGTTTCGAGGGTTTTGGTGTAGATGGCACGACCACCGAAGAAGGGGTGATCCCTTAGTTCGGCGGGGACATTCCAGTGGAGGTAATAGCGTCGGCGGCGAAGTTGGAGATGTTTCATCATGTGATCCCTATGTGTTATCTTAGGGTCAGTAAAAATGACCCAATCCATAGCACACTTCGCATCACAAGCTATTGATTTATAGGGGATTCAACAACTTACCTACCGGCTGATTTGACATTGCATGTCATTGCTTTATGTTAGCCGGCAATGATAAAGCATTATTGCGGCCAGGGCTAACAGCCAAGTGCTGCTTTCCAATTTGGTTCCCGACTCATGCACGATCGCGCTTCCCTGCTTTTGCAATGGGCTCGCCGGATTTCCGGTGACGCCAACCTCTCGTTGACGCTTATTTCCGGTGACGCCAGTTTCCGCCGCTACTTCCGGGGCGGCGGTCTGGTGTGGGTGGATGCTAATCCGAAAACCGAAAAAAATCATGAATTCGTTCGCAATGCGGCCGCCCTGCACGATGCGGGGCTGCTGGCCCCCGAGGTAAAGGGGGTCGACTACGAGCAGGGATTGCTGGCGGTGACGGATCTGGGGGATACCCAGCTTATCGGCTGCCTGAACGAAGAGAGCGTACTGGCCTGGTATGGCAAGGCCATCGCCCTGCTGCCAAGGCTCGGCGCCGTGGCGCTCGAGCTCGAGCCCTTCGATGAGGCCTTCATGGCCCGGGAAAATGCCATCTTCCCCGAGTGGTTGCTGGGACATCACCTGCAACTGGCCCTGAGCGATGAAGAGCAGCAGTTGCTGGCGGAGACCTTCGCCTGCCTCACGGCGAGCAACCTGGCCCAGCCACAAGGAGTGATGCACCGGGACTTCCACAGCCGCAACCTGATGGTGTGCGGCGGGACGAACCCGAAGGAGAGCGACCTCGCCCTTATCGACTTCCAGGACATGGTCATCGGGCCGCTGAGCTATGACCTGGTCTCCCTGCTCAAAGATTGCTACGTGCGCTGGCCGGACGCGGTGATCGAGCAGGGCATGCGACTTGGCTTCGACACCCTGCAAGGGGCCGGTCTGCTCGGCAATCTGGACTATGCCGCGTTTCGTCGCGCAGCCGATCTCACCGGCATGCAGCGCCACCTCAAGGCGGCGGGGATCTTCACCCGCCTCTATCACCGCGATGGCAAGGCCGGCTACCTCAAGGACATTCCCCGTACCCTGGGCTACGTCGTTGATGTCTGTCGCAGCCATGGCGCCGCCTATCCGGTGCTGGCCCGCTTCGGCCAGTGGCTGGAGCAGGTGGTGCTGCCCGGATTGGCGCGCACCGGGGTGACACCATGAAGGCGATGATCCTGGCCGCCGGGCGCGGCGAGCGGATGCGTCCGCTCACCGATCTGCTGCCCAAGCCGCTGCTGGCGGCGGGGGGCAAGCCGCTCATCGTGCACCATATCGAAAAACTCAAGGCAGCCGGCGTGACCACACTTGTCATCAACCACGCCTGGCTCGGACACAAGCTGGTGGCGGCCCTCGGCGATGGCAGTGCACTCGGGGTCTCCATCCACTGGTCGGCCGAAGAGAGCGCGCTCGAGACCGCCGGCGGCATCGTGCAGGCGCTGCCCCTGCTGGGCTGCGAACCCTTTCTGGTGATCAACGGCGATACCTGGCTCGACCTGGATTATCGCGCTCTGGTGAACCAGCCGCTTGGGGAGGATCTCGCCCACCTCTGGCTGGTGCCCAACCCTCCCCAGCATCCGCAAGGGGACTTCTCCCTGCAAGCGGGTCGGGTGCTGGACACCCCGGCCCTCACCTTCAGCGGCGTCGGCCTCTATCAGCCCGCCGCCTTTGCCGGCTTGCCCTGCGGGGCGCGCAAGCTGGCCCCCCTGCTGCGCGACTGGATGGCGCAGGGACGGGTGGGTGGCAGCCTGCTGGCAGGCGAGTGGCGCGACATCGGCACAGTGGATCGGCTGCGCGAGCTGGACGAGCAACTGCTCGCCGGCACCCATTAACATCACGAGGTCTTGAACCATGCGTATTTGGGGCAAGGTGCTTGGCACCTTCTTCGGTTTTCTGCTCGGCAACATCTTCGGTGCCCTGCTGGGCCTGTGGATCGGCCATCGCTTCGATCGGGGCATGGGGATCCGCGGGGCCTTCCAGCGGGCGCCCAGCCAGCAGCAGCAGGCCGTCTTCTTCCATGCCACCTTCGCCGTCATGGGCCACATCGCCAAGGCGAGCGGCCAGGTCACCGAGCATGAAATACGGGTCGCGTCCAACCTGATGGACAGGATGCGGCTGGCCGGAGAGCAGCGAGTACGGGCCCAGGAGTCATTCCGCCAGGGCAAGGAGAGTGACTTCCCCCTGCGCGAGACCCTGGCGGAGTTTCGCCAGGCGAGCCTGGGGCAGCGTGACATCCTACGCTTCTTCCTCGAGGTCCAGCTGCAGGCCGCCTTCGCCGACGGTCAGGTGGAGGCGAACGAGCGGGCCATCCTGCAAACCATCGCCGACGAGCTGGGGTTCAGTCGCATCGAGCTTGCCCGCATTCTGGCCATGGCCGAGGCCCAGATGAACTTCTTCCACCGCCAGCAACAGCAGGGCAGTGGCCAGGGGCAGCAATACCGCCAGGAGCCCCCCTCCCGGGATCGCCTCAAGGATGCCTATCAGTTGCTCGGGGTGAGCGAGAGCGACAGCGATCAGGAGATCAAGCGCGCCTATCGCAAGGAGATGAGCAAGCATCACCCTGACAAGCTGGCCGCCAAGGGATTGCCCCCCGAGATGATGGAGATGGCCAAAGAGAAGACCCAGGAGATCCAGCAGGCGTGGGAGTGGATCCGCGAGGCCCGCGGCATTCGCTGAGCCCTGTACCCGCCATAAAAAAATGCCCGTCGATGACGGGCATTTTTGTTTTCAGAGTCTGGTTTTTCTTTTCATGGAAGAAAAATCAGTGGGCATCGACCCAGACAAACTTGAGGACGAAGAGCAGGGCCACCACCAGCACGCAGGGGTTGATCTCGCGCCAGCGGCCGGTGCCCGCCTTCATCACGCAGTAGGAGATGAAGCCCACGGCGATCCCCTCGGTGATGGAGAAGCTGAACGGCATCATCACCGCGGTCATGAAGGCCGGCACCGCTTCGGTCAGGTCTTCCCACTTCACCCGGGTCAGCTCGGAGCACATCAGCACGCCCACGTAGATGAGGGCCCCCGCTGCGGCATATGCCGGCACCATGGCGGCGACCGGAGAGAAGAAGATGGCCAGCAGGAACAGGATGCCCACCACGATGGCGGTCAGACCGGTGCGACCGCCGACGGCGACGCCGGAGCTGCTCTCGATGTAGGCCGTCACGGACGAGGTCCCCATGAAGGCGCCGCCGACGGAGCTGACGCTATCCACCACCAGGGCCTGCTTCATGCGCGGGAAGTGCCCCTTGTCATCGGCCAGCTTGGCGCGGTTGGTCACGCCGATCAGGGTGCCGGAAGAGTCGAACAGGTTGACCAGCATGAAGGAGAAGATGATCCCGGCGAGGCTGATGTCCAGCGATCCCATCAGATCCAGCTGGCCGAAGACCGGGGCAATGCTCGGCGGCACGGAGACGAAGCCCTTGAAGGTGACGTCGCCAAATAGCCAGCCCAGGGTGGTGGTCACCACGATGGCGATGAGCACGGCGGAGTGGACGCCGCGGGCGGAGAAGATGCAGATGAGGAAGAAGCCGAGCAGCCCCAGCAGGCAGGGCAGGGAGGTGAGGTTGCCCACGGTCACCATGGTGGCGGGGCTCGCGACCACGATGCCGGCATTGTGCAGGCCGAGCAGGGCGATGAGCAGACCGATGCCGGCGGTGATGCCGACCCGAAGTGTCAGGGGAATGTTGGCGATGAGCCAGTAGCGTACCCGCAGCAGGGTCAGGATCAGCAGGCCCAGCGCACCCCAGAAGATGGTGCCCATGCCCACTTGCCAGGAGTAGCCCATGCCGGCCACCACCACGAAGGCGAAGAAGGCGTTGAGGCCCATGGCGGGAGCCAGGGCGATGGGCAGGTTCGCCAGCAGACCCATCAGGATGCTGCCGACACCGGCGATGAGGCAGGTGGTAACGAACACGGCCTGGGTGTCCATGCCTGCAGCAGAGAGGATCTGCGGGTTGACGAAGACGATGTAGACCATGGTCAGGAAGGTGGTGATGCCGGCGATCACCTCGGTGCGGGCCGTGGTGCCATGACCGCGCAGGGCAAACAGGCGCTCGAGCAATCCCTGCCCGGCAGCCGGGCTGGCGGTCTGCCCGGTAGCGTGATGTGGTTGATTCATGTTGGATTCCAATGGGTGACGTGAAATAGGCAGCAGGAGGCCCGGCCCATCCATGCGGGGCTACGGACCCTGATTCTGGCGGTGAAGTGACCAGACTCGTCCTGATACCGTGACAGCGCGCACATTTTCACACAGGCGGCCAGGTTTACAAACCCCGGATGTGCGAGGCGGATCAATGAATAGAGTAAAAATTCAAACGTTTTCCCTCGGAGGCAGGAAAAAGGGGACCAATAGAGCCCCGTTTCCACATCGGGATCAACGGTTTTTCTGGTAGCGTTCGATAAGCTGGCTCAGCACGGCATCGCTCTGCTCCAGCAAGGGAGCGAGGGCCAACCCCATGCGTTGTAGCAGCAGGGTGGCCTGGGTTTCGCTCAAGGGACGGCCATCGAGGAAGTAGGCCTGCTCGGCCAGTTGCTTGTCATGGCGGGGCAGCAGCACCCAGTGCACCCGTTGGGGTTCGATGGCGGCGAGGATCCGGTTGGCGGCCGCGCAGAAGGTATCGATGTGCTGCTTGCCATCCGGCCCCAGACAGCCGGGTTCGAGCCGGATCTGGATGGTGAGTCTGGTGGTGGAGGCTTGGGTCATGGGTCGCTATCGCTGGGGTAGAGGTGGAGATTGTAAGTCAGAAGAGGCAAAAAAGGGGAGCCCCGGCTCCCCTTGTGACGTCATGCCTGGCGGCGCGGCTGTTGCCTCGCCTTACTTGGCAATGCGCTTGTACTTGGCGCGGCGCGGCTGGATAGCCTCGGCACCGTAAGTCTTCTTCTTCCACTCTTCGTATTCGGTGAAGTTGCCTTCAAAGAATTCGATCTTGCCCTCGTCCTGGTAGTCCAGGATGTGGGTGGCGATGCGGTCGAGGAACCAGCGGTCGTGGGAGATGACCATGGCGCAACCCGGGAACTCCAGCAAGGCGTTCTCGAGGGCGCGCAGGGTTTCGATGTCCAGATCGTTGGTCGGTTCATCCAGCAGCAGCACGTTGCCGCCGGTCTGCAGCAGCTTGGCCAGATGCAGACGGCCACGTTCACCACCGGAGAGCTCGCCGACCCGCTTCTGCTGGTCGGAACCCTTGAAGTTGAAGCGGCCGATGTAGGCGCGGCTCGGGAACTCGTAGTTGCCGATGCGCAGGATGTCCTGGCCGTCGGCGACTTCCTCGAACACCGTCTTCTTGTCGTTCATCTGGTCGCGGAACTGATCCACGGAAGCCAGCACCACGGTGTCACCCAGGGTGATGGAACCGGAATCCGGCTGCTCCTGACCCGACATCATGCGGAACAGGGTCGATTTACCGGCACCGTTCGGACCGATGATGCCGACGATGGCACCCTTCGGAATGGAGAAGGAGAGATCGTCGATCAGCTGGCGGTCGCCATAGGACTTGCAGAGGTTGGCCACCTCCACCACCTTGTCGCCCAGGCGCGGTCCGGGCGGAATGAACAGCTCGTTGGTCTCGTTGCGCTTCTGGTAGTCGTTGGTGTTGAGCTCTTCGAAGCGAGCCATACGAGCCTTGGATTTGGCCTGACGGCCTTTCGGGTTCTGACGGACCCACTCCAGTTCCTTCTCGATGGACTTGCGACGGGCGGCTTCGGAACTCGCTTCCTGGGCCAGACGGGCATCTTTTTGCTCCAGCCAGGAGGAGTAGTTGCCCTCCCAGGGGATGCCTTCGCCGCGGTCCAGCTCCAGGATCCAGCCCGCCACGTTGTCGAGGAAGTAGCGGTCGTGGGTGATGGCCACGACGGTGCCTTCGTAGTCGTGCAGGAAGCGCTCCAGCCAGGCCACGGATTCCGCATCCAGGTGGTTGGTCGGTTCGTCCAGCAGCAGCATGTCCGGCTTTTCCAGCAGCAGACGGCACAGGGCCACGCGGCGGCGCTCACCACCGGAGAGGTGCTTGATCTGGGCATCCCAGGCCGGCAGGCGCAGGGCGTCGGCCGCGCGCTCCAGCTGGTTTTCCATGTTGTGGCCGCCCTGGGCGGCGATGATGGCTTCCAGCTCGCCCTGTTCGCGGGCCAGCTTGTCAAAATCCGCATCCGGGTCGGCGTAGGCTGCATAGACCTCGTCGAGGCGCGCCATGGCGCGTTTGACGTCGCCGACCGCCTCTTCGACCGCTTCGCGTACGGTCTGCTCCGGATCCAGCTTCGGCTCCTGGGGCAGGTAGCCGATCTTGATGCCGGGCTGCGGACGGGCTTCCCCTTCGATCTCGGTGTCGATGCCCGCCATGATGCGCAGCAGGGTCGATTTCCCGGCGCCGTTCAGACCCAGCACGCCTATCTTGGCCCCCGGGAAGAAGGAGAGGGAGATGTTCTTGAGAATATGACGCTTGGGCGGCACGACCTTGCCAACCCTGTTCATGGTGTAAATAAATTGAGCCATTGGCTAATTCTCTTTAATTTACAGGTTGTTATTGTGTTGCTTTGAAATCTTGGGGCTGTATTGGGGCCAAATCTGAAAAGTTGGCTCCAAGCCTGCCCCAAACCCTGTCCGCTTCGTCGCGGTCTTGTTCGGGGATCCATTTGCCATAGACTGTTCGCACCATGGTGCTGTCCTCGTGCCCAAGGTAAGACGCAACCCATTCAGGGTTTGCGCCAGCGGTCAGCATCCAGCAAGCAAATGTATGGCGCATATGGTATTGGGTTCGGCGGCGAATGCCAGCCCTCTTTATCAACCTGTCCCATTTGTCACCCAAGGTGAAGGCCGTGTAGCAGATGCTGAGCCCGGGTGTCTTGCTGGTTACATCGGGGCTGAACACGAACGTGACCTTTTCATCTACCTGCCGGCGGTCCCGCAGCGTCTTCTTGATGTAGTGGGATTGGCGCATGGCTGTCATTGGCCGCATGCGTCTTAGTGCCTCAATTGCCGGTGGGAGGAGCACAATCGTTCGCTCATGACCTGTCTTCGGCACCTTGAAGTTGCGGGCCTGGGTGATGTTGCGGCGGATCTGCAATTCCCCGCGCTCCAGGTCAACATCCTCCCATGCCAAGGAGCAGAGCTCCCCAGTACGCATGCCTGTCCAGCAGGCGAGCTGGACCCACATTGCGTCCATGTCGTGCCTGGCAGACTCCTGCAGGCGACGAAACTCATCTTGATCAAATGGGTCTGGTTTATCCCGGATCACTTCCACCTTGGTCAGCACTGAAGAAAGGTCCTGATGGGTGTAGCCGTTCTGCTTGGCGAAGTTGAACAGCCCAGCGGCGACCATCATGTAGTAGTTGACCGATCTCGGAGCCAAGGGCTTGCTGGTTCTGTTACGCGGCTCGGTCATCAGGTACCGGCGCCATTGCTGCAGGTCTTCGGTCCGGAAGGTGCTGACGACCCGGGTGTGGTCCAGGTCAGATGCCAGCATCCCCAGGATTGAGCGATATCGGCCACGGGCGTTATCGCCTATGTCCACATCCTTGATCTTCAGGTAGTGCTCTACCAGGTCGCCCAGAGAGATGTCCCGGCTTGCGGTCGTGCCGGCGAACCGGTGGGCGTTCTTACTGTCTGGGAAGTGTTTGGCGTAGTCGAAGACACCGATGGCGATTTCATGCAGGATAGCCTCCCGCTTGCGGGAGGCGTGCTTGATGTTGGCTTTGGTGGCCGGCATGTTGAGCGTTTCCCGGCATCGCTTGCCGTGGAATCGGAAGTCGATGCGAAGACTCTTGCCGTGCAGTTCGACACCTGGTGTTTCAGCAACGATGTCGATCAGTTCTTGGTTCCGGTCAGCCAATCCTCATATCTCCGCCAGTGATAGACATACTTCCCATCCGGGGCCAACTTGTAGTGGACCCCCTCTATAAGCTGGCCCTTCTTCCGCTTCTCGCTGATGGCCTTCTCAGTGTACCCGAACATCTCTCCCAAAACTCGAGGCAGAACCCAGCTGGGGCGTTCCATCACAACCACTTTCTGATGCATATTCATGTCTCCTTTACGCCTCACGGCGAGAAGAGCGGCCCCATGGGGCCACTGTCTTTCGTTACGCTAGAACGGCAGATCGTCGTCATAAGCGATCGGTTGTTCGGTGTAGGCCGGTGATTGCGCCGGCTGTGGCGTTGGCCTTTGCTGGCTGCCTGCCGCTTGCTGTTTCCCTCCTCCGTTTTGCCCGCTTCCTCCAAGCATCTGCATCACCCCTGTGAAGCTGTCCACGAGCACCTCGGTGGTGTAGCGCTCCTGGCCGCTCTGGTCCTGCCATTTGCGAGTCCGCAGTTTGCCCTCCACATAGACCTGAGAGCCCTTCTTCAGGTGCTTCCCTGCCACCTCAGCCAACATTCCCATGAACACGACACGATGCCACTCGGTGCGCTCCTTGGCCTCGCCGGTCTGCTTATCGCGCCAGGTGTCGGAGGTCGCCAAAGTGATGCTGGTGACAGCGTTCCCGCCGGGCATGTAGCGCACTTCGGGATCCTGGCCGAGGTTGCCGATCAGGATGACCTTGTTGATACCGCGGCTGGCCATCAGCGATGCTCCTGGGTTTGATAGAGCTGCTGGAACTTGGTGTTGACCTGCCTCCATTGGGGGTCCTTTGCCTGCTTGAGGCAGTGGATACGGCGAGCCATCGCGAACTTGGCCTTTTCCAACATATTGGCGCTGGTGGCGTGGTGCTGGGCTTTCTTGTAGGAGAGGGCCGCATCCTGATGGTTGCCGGCATGCTCCTGCTGGATGGCCTGCTTGAGATCATCCCGGTAATTGCGCTGGTAAAGTTTGATATGCATCGTGTCCTCCCGGACAGTCGTGGTTCGTTACATCCAGGCCTGCATGGCCGGGCATTCAATTCAGGGGGCATTCAATCTCCTGGTACTCCAGTTCGTTGAAATTCAGATACTGGGCCGGGGCCTTGTCGATGGCGGCCAGCCGGATCTGTTGGTGGGTCATCGGGTGGTGCGCCTCGATGGTCCCGGTCAGGCGATCCGGCGCAGCCCCCAACTCTGTGGCCGCATTCAGGGTGTAGGTGTAACGGTGCATTGGCCTGCTCCTTTGGTTGTGTCGATTTGCCAGCGATAACCGCCGTGTTGTTTCTGCTGGCCGGCAAGACAGCGGGTGATGCCGACCCTGACAAAACCGCCTTTGGTCTCTGCATCAGTGACACTGTCGAACCGGACGACCTGATCCCCATTGATGCCGATCACCGGGGTCTTGCGCCATTGCGGCGGTTTGACTGCATCAACGAAGAGGCGGCGGGTATGGCGCCCGCGACCGTTGTCCCCAACCATGCAGAAGTGTTCAATCCGGGTGGTGAAGCGGGCCTCCCTGTGGATCTGGCCCATCACGATGCTGGCCTCACTGACAGTGAGGGAGAACTCGGCGGCTACATCGGCACTGATGGCGCCGCCGGTGCGGGCATGAATCCACTCGGCAACGTCCTGAACAACGCTCATGCTGCCCTCCTGGCTTGCAGCTGCTTGTACGGGTTATTGGCTCTGGCGATGGCCGCCATCGGCGGCGGGCTGACGCTGTTGCCCACCATCAACACTTGATCGGTGATGGAGAGCGGGGTGCCGTCGTGGCCGCGGTCATGGATGTAGTGGCGCGGCATGCCCTGGCAGCCATAGAGCTCTTTCGGTACCAGCATGCGCAGGCCGATATCCACGATCACCCAGGTGTTGCCGCACCAGGTCACGGTCACCAGTGCCAGCCGGTCCTTGGTGGTGATGGTGTGCATCGGCTCGGTGACAGCACCCCACTGCCCGCCGCTCGAGTAGTAGCGCATCAGGAAGGCGCTGACCCGCAGGGCTCCGGCCTCTTGCTCCGGTGTCAGGCCGCACTCACCCGGGCTCGCCATCACGGTCTGCACCAGGGCGTGGTGCTGGCCCGCTGAGACGATGGTGGGGAGCTGGCTTTCTGGAGTGCTCGGTGGCAGGTTCTTGCGCAGGTGCACCATGAAGGCTGAGGCCAGTTGCTGCTGGCTGCCGCTCGAGGTGATGGTGCTGCATGGGTCAGTCACGGATCTGGCGGGCACGGTGTTGAACCCACCATTGGCCTGCACCATCAAGGGAGCCGCCAGCATGGACTTGCCACCGCCGCCGGCCATGATGGCTGCTGCAGGTTCATCCACCCCGTGCTCACCCCCTTTTCCGAAGTGGCGCACCACCAGAGGGGCCAGACTCGGGTTGCACACGGCGAACGCGCCACCCTTGGGCCAGCCTGTAATAGTGCGCAATGGGGCATCAACCGAATCGACACCGCGCCCTGACCAGTTGGCCAGCTCGATGACGAAGGGCTTGGGATTGGTCAGCACCTCGCGGATCACCCCGATTGCCACGCGCTCCAGGGTGGCATCGGCCAGTGGGCGTTTGACGTTCAGCCCCTGTGCCCGGGCTTCTTCCTTGGTGAGGAAGATGCTGGGGCAGGGGATAGACCAGTCGATGTGATCCGCCGTTACCCGATAGGGCTTGAGGTGGCTGCCTGGTGCCGGGGCCTTGCAATGCGTCGGGGCGGGCCAGCAAACGGGTTCCCCGTCCCGGCGGGCAACGAGGTAGAGGCGCTGGCGGCTGGTGGCCGCACCGTAATCGGCTGCATTCTTCACGGTATGGTCAAGCTCATACCCCATGCGCTCGATGCTGGCCAGAAAGCGGCGCCAAGTCTGGCCTGCCCGCTTGGGATCCGGCACAAGGTATTGCTGCTGGCGTGGCACCCGCTCCCCGGGCTCGGCGATATGCTGCTCGATCTTGGTCTTCTTGCCGCGCTGAACCTCGACCAGCTTGATGACCCGGCCAGTGGCCTTGTCCCGCTTGGCGATGAGGGGCCCCCAGGTGCGCATCTGCTTGACGTTCTCCATGGAAAGCACGGCAGGTTTGCTCAGGGCAAGCCATTTGGTGATCACCCATGCCAGGCTGCGGATCTCCTGCTTGCGCGGCTGACCGCCGGCGGCCTGTGAGTGGTGGGTGCAATCCGGGCTGGCGTGCAGCCAACCGACCGAGCGCCCTGCCAGCACAGCAACCGGGTCCACGGCCCAGATATCCTCCTGCAGGTGCAGGGCCTCCGGGTGGTTTGCCTGGTGCATGGAAAGAGCCTTCGAGTTGTGGTTGATGGCGATGTGCACCGGGCGCCCCAGCCCACGCTCGATCCCGGTGCTGGCACCGCCGCCGCCGGCGAACAAGTCCACGTTGATGGCAGAGTCCAGGTTAAGCGGGGCCCCGGTCACCTTGGCCCTGACGGCGCGGGAGCGGCGAAGTGATTTGCTCATGCCATCACCTCATTCACTCGGGTAATGGCGTTGATCATCACGCTCTTTTGCGTGACGGGGCTGAGGGTCGGCTCGTTATGCAGGGCGTTCAGCAAGGCGATGACGGCCTCCTGGCGGTGCAGGTCGAGCATGGTGAAGGCCTCTGTGAAGTTGTATCCCTCAACCTGCTTCAGAGTGGAGACAGTCTTGCGCAGCAGCGCTTTGGTTTCCTCGTCCAGAGTGGTGTATTCGTCCATGAGCTGCTCGTCGCTGACCGAGATGGCGATCGCTACCTCCCGGGCGGTGTAGTGCTCCTTGGCGCCGTAGAGCACGGTCAGCACGGCGACGAAGCACGACCACTCGGCGCCACCCAGATTGAGCTCGTCGTTCTGGTAGTCGAAGGCCCAGTCTTCCAGCGGCTTGATGTTGGGGGCCTCGTCTTGCTGGTGGCTATCCGGTTCTGGCTCAGACAACAGCTCGAGCTGCAGTTCGCTCTGCACAGGTTCGGCACTCTGCGCCAACAGCTCGGCGGCTTTGGCGGTGGCCTGTGCCAGCAGATCGCCGGGGGCCGTCAGGTTGTCGATGATCCAGGCGGCCAGCTCGGCGGTCCTGGCCGGGGTCAGGATGTCCGCATCGTCGATCTGGTAGATAACCCCCTTCACTGCGGGGTGGCGCTGCCAGTGGGGCAGGGCGGGTGATCGATTATCTTCTGCGACAAAGCCCTGATGGATAGGCTTACCGGCCAGCAGGTTGGCGACGGCCAGATCAAGCCGATAGAAGATCTCGGAGAGTGGATAGGGCTCGTCCAGCCAACCCTGCACATAGCCCCTGACCGTGGCCAGCTGCTCTTCGCTCAGGTCGCTGCACTCGAGCTGTTTGCCCATGATGCTGCCAGCATCGGAATAGCCCTGCTCGGCCAGCATGGTGCTGTCCGTGATGGGCAATACCAGCTCCAGCATTGCCAGCTCGTCAGCCGCAGCGGCGTTGGTCGTGTCATCGCTGGCCACTGGCGGTTCCCACGCTGTCGGCTTGGCGACGGCAGGTTCGTCCAGCAGCATGGCTGGCTCGGTAGAAGTGGCCTTGGCGATGGCCTGGCTGGCTTCTTCGTTGAGGGCAACCGCCTGGCGGTGGATCATGTCGAGGATGATCTGGCCGGTGGTGATGAGGTCATCCCGGCGCAGGCGTGCCTCGGGTCGACGCTCGCCCTGCCAGCTTGCATCGAAGATCGCCACGGCAGAGGCAAAGCCGCTGGCGCTGGGTTTGTCCTGCTTCGGATCGCGGGGCACGTACCAGCTCGGGACTTCAAAGCCGATGCGGCCGCTGATGAACTGGATGAAGTCGGCATCCTCCGGCCACCAGGTCTCGCTGGTGGCTGCCTTGATGAGCAGCATGATCTTGGCGCCCTGTGCCCGCTGCTCGCGGCAGTAGTTGAGGATGGCCTCCATCCCGGTGATGGGGTTGCCCTCGCTATCCGTGCAAGGGCGGGAGTAGGGCGGGTTGCCGAAGGCGGCACCACCGAAGCAGCGCAGGTCGGCGGCCAGCTCCTGGGTGAGGGCATTGTCTTCGGCGTCGTAGTAGTGCGGCACCAGAGCGTTGCAGTCATCGGCGAACATGTCGAGCACTACCGGCCCCAGGGTGGGGGCGAACTGGTGGAACAGGCCCCAGGCCAATGCCTTGGGGGTCTGCCATTGGTCGCCAATCTGCTTGAGCTCGTGGTCAGGCTGGGCCTGCAGTTCTGCCAGCGCTTGGGCGTAGTGGTTCATCGTTGCCTCTTCGTTGAGATATGACCCGCTCCCCGGATCAGGGCTTGGCCTTCTTTGCGACCCTGGCTACTGCGCGGGCCGCCTTGAGGCACTCATCGAACACCTTCCCCTTGGCGAAGCTGGGCGTCCGGTCAAAATAGAAGGTGGCTTCTTTCACCCCCAGCGAGACCGCATGGGGGGGGAATTCCTCCTTCTCCAGCGTTGCCTTGATGTGCTTGGCAATGAACTCGCGTGGGTGCATGGCTGCCTCCGCTATGTCTGAAATTGGTCTCATCACGCAAGCGACAGGCAATAGGAGGCCGTGACCCGCTGTTGGGCCGCTATCGCTTGTGGGATAAGGGCCCCGTTGCCGGGGCCAGGAGAGAACAACTCGGGCTGATTGGTCAGGGCCCGGAGCCCTGTGCCAGCATGGGCAGTGGTGCTGCCCTTGATGGCGCCGTCAGGTGGGTGACGGCTGGTATTGCAAGTTGGTCAGCTGCCAGCCCGAGCAGCCAGATCAACATCAGGAGTAGTAACCACATGCGTTGCACCTGTGGTGGTGGCTTGAGCACTTCACAGTGAGTCAGCCGTTCTTGCTATTGGTACCGGTGCGCCCTCACGGGCAGACCTACCTATCGAAACTGTCGCCTCTCGGCGAGGGCCTGGGTGGCGCTTCACAGCGGGACCAGGCGACCGCGTAACCCTGCGGTGGGAGATATGATCACCTCCTTGGGGTGGTCAAATCGGTTGGCTGTGGAGGCCGGTGATGTCTTCTCATGCACCATCTCGTCATTCGCGTGTGTTTCCACCCCAACAGGGTCTTGTTGTCACACGGTTTCGTCCGGCAGCTGCGCTCGCCATCACCACAACTGCGGATTGCACTGGCATCATTGCGGTGTACCGAAAGAACCGGCAGGCCTACCATTTCCAATGCAATCCCAGTTGTGTCCCGGCCTTTCACCGGGGGGTGGCTGGGGAGTCAGACCCGCCACTCGCTTCGTTCGCTATCACTTCAACAACGCTGTCTTTCCAGCTGCCAGCCGGTCACTGACTGTGTTTTCCGGTCACCTTGGTCGGCACGCATACCAGCCTTGCCAAGGGAGAGCGGGGAGGTGAGTCAGCCCGGTTGCCGGTGTTATGTCCCCAAGCGGTTTGTTGCCACCGCTGCCAGTGTTGTTCTGGCCCTCCGGCTGGGGTCGTCTTTCGCACTGAATTCAATTCCTAACTTTTGGTTAGCATATATCAGGTTTGTTTTCGATCAATACCCGAAAGTTAGGTTTTTTAGTTTTTTTTCATTCAGGCTCATTCGGTGCAAAACTGGGACGTGCTGAAGGGAGGGATGCCGAGTGAGCAGGTTGATGGAGTGCCAAGCGTGTCATGCGCTGATTGAGGAAGGAGAGAGCCCGTGCCCGCAATGCGGGTCCACGCTGCTTGGCGGGGTGGGGGCCGACCTGGCCCATCAGTTGGCGGTGAAGCAGCAGCAAGAGGCGTTTGTGGCCACGTACCACACCTGGTCTGATGGGGGCTGGGAGGGGATAGGGATAGACATGGTCCGCCACCGGTTGGCGGTGCGCTTTTTTGATGGGCATATCCGTGCCCGCAAGATCATCCAGGGTACGCAGGTGATCGGGGTCAAGGTCAGGGAGACGGCCGGCGCCACGCACACCAAGACGCAGGGCGGCAGTCAGCTAGGTCGGGCGTTGGTTGGCGGTGTGTTGATGGGCGGTGTCGGCGCATTGCTGGGCGGCCTGAGCGCCAAGCAAACCAGCACGGGGACCGTGTCGTTGGTGCAGGTGTTGATCACCACCCAGGAGCCCGATTATCAACTGCTGAGCATCACCCTGCTGGCCGGGGAGTTCAGGGCAGATTCGGCTGCGGTGGCGCAGGCCAGACGGTCTGCAGAGGTGTGGGTGGCGCGAGTAGAGGGATTGATCCATCAGTGCGCCGCTCAGGCGGTGAGGCCTGAGCACGGCGGCAGTGTGGCAGATGAACTGGGCAAACTGGTGTGGCTGCGTGAGCACGGTGAGATCACCATGCAGGAGTTCGACCTGCTCAAGCGGCAGTTGCTTGCAAATCGCGATGCAGATTCATAACCCGATTGCGGATTGGCGTTACTCGACCATCACCGAGCAGACCAGTACGGCGCAGATCTGCACGTCTTCATTGACCGGCAGCAGGGGGTATTGCGGGTTGAGGGGTTTTAACCACCAGGAACCGGAATCCATCACCAGCTCTTTGAAGGTCATGTCGCTGCCATAGCGGGCTATCACCTTCTTGCCATGGGCAGGTTCCACTTCTGGATCCACGATGATGATAGTGCCGTCAGGGTATGACTTTCCCCCCATGGGCGCGACCATGGAGTCACCCTTCACCCGCACGGCATAGGCCCGGGTGCTGACGCGAACTGGGCTGATGGTGACCTCTTCTGCCTCTTCCAGACTCGGGATGTCGCCGCAGTCCTTAAACTCCCCGGCACTAACCCACGAAATCAAGGGCACCTGGTAGATAGGGAACGGTTGTGGCTCGATATTGCCGTCACCCGGATCGGTGCCTGTCAGCAACCACTGCACACTCTTGCCAGTGATGCGCGAGAGCTCTCCCAGGCGCTTTACTTCAGGCAACCCCTCACCTTTGAGCCATTTGCGTACAGAGATTTCAGACAGGCTTTCCCTCAACGTGCGTTTAAGTCGAACTATCCGGCCTCGAGCAGGCCAGCCCAATTCATCGAGAGCGGCATTAAGTCGCTGCGAGAATGCAATTTTGTCGGCTTCAAAACGCGCCATTGGTGTCTGTTTCTCATCCATTTCCTAACGTCCAGTTATTGTTTGTCAATTTCGCCTAACTTTAACCTCTTGCGAATTTTACTAACCAAGAGTTATGATTTGGTGTGTGTTAAACGCCAGAGGACGCCATGCATACCCTGTTAACTCGATTCGGTACCAAGAGTGCCATCGCGGCTGCGCTCGGCATCACCCCGGAGGGGGTAAGCAACGCCTTCAGGCGTGGCAAAGTGCCAAGCACCTGGGTGGCCAAGCTCAAGCAGCAAGGTTTGAGCCAATCTGAGCTTGCTGAATTGCCTCTGACCGACGAAGGGCGGGCGATTGTATCAGCATTCACCGGGCATTTATAACCAACCGTTAGGGATCACTATGACAGAGCAACGGAATGACACCACGGCAAAAGTCAGTGCGGTTTTCCGGTCATCGGACGTGATGGCGGCGGCTTATGGCATTGGCCATCGCTTCAACGCCAGCGAACTGGCGCGGCTGATGGGGCGCAAACCGGCGGAGTTTTGCAAGAAGCTCAACCCGGATTGCGACGACCGCCATCTCACCCTGGCCGAGGCGGTTGCCGTCACCGAGATCACCGGTGATAACGCCATCCTCGATGCCTGGGCCGTCAGTCGGGGCAAGGTGCTGGTGGACTTACCAGCGGGGGTCGTGAGCGATGACGACCTGGTAGAGCAGGTGCTGCTGGCGCAGGCGGTGTTCGGCAAGTTGATGCAGGCCATTCACGACGCTCGGGCAGACGGGGTGATCGACAGGATAGAGCAGGGACAAATCGAGCGCATCGGTACCCAGGCCGCCGAGCATGTGCTGGGGCTGATCAGCAGCACTGGCGCAAATGTGCGGCAACTGCCGACGACTTCCAGCAAGTAGATACAAGGCGGCCCCGCGCTGCGTCAACAGCCGAGGCCATGGTTCAGTCATCGATTGGGGATGAGAACATGGAAAAGCATACGGTTAACAATGCCTTTGAGCAAGGTGCCAATAGCATGTCTTTGGTCGGGCATCAGCGGCCAGAGCTGCCTCGGCCTTCACTTCCGCGTCAGCGTCGACCCAGTGTCATTCCCAGCATGCTGCCACGACTGGTTTGTAGCCAGTGCGGCACATTCCTGGTTTATGGCGGGTTCCGTGGCGGAATCAAGATCCCCGTTTCCCCGGAGCAGGCAAGGCGCCACCTTGACTGCCTGATGCAGCATCTACGGGAGGTGGGCCATGGGTGAGGTGATCAGACTGGCGGCCCCGGTGGCCGCCTCAACGCAACGAGGTTGCAACGTGGACGACAATGCCCGCACCGGTTTTCGCCTGTTCTACCGCAGCATGAAGAACGCGGCCTGGTACCGGGATGTCGCCAAGAAGGCGGTGATGTTTCACCTGATCCTCGAGGTGGCGCACGAGCAGCGCACCGTGGTGTTTGGCGGCAAGCGGGTGCAGCTTTCCCGCGGGCAGTTGGTGTGCTCGGCCAAGAGCCTGGGGCAGGAGTGCGGCATTTCGGAAGATCAGGCCCGCCGGGCGCTGGAGTTCTTCAAGGCAGAGGGGGCAATCAGCTGTGTGGGGGCCCGTGGCAAGGGGGGCTATACCGTGGTGAGCCTGCTCAATTTCGATGCCTATCAGCGCGGATTATCGCAAATATTTAGCGCGGAATATGGCGCGGATTCTGAGGCCGCGCCAGCACTGGGGTTGGAGGCTGGTTCGCAAAGTGGCGGCGCGGATTTACCCGCCGAACAACACGCCGAAGACTATATCAGTAAGAACATAAAGACAGATCTTAAAGACTCTTCGTCTCAACTCGCTGTCGCGACTTTCGACCAGCAGAGTGAACAGCCTATCGCTGATGAGCCTGTCACTGCTGACCCCCTCCCTGATGAGCCCACTGTTGCCGAGCCCAAGACCAGGGTTATCCCAGGGGCTGCGATCCAGACGCCCAATGGCAAAGCCTGGGGTACGGCGGAAGACCTGACGACCGCCCAGTGGATGTTCAAACGGGTGCAAGTGATCGCGCCCACCGCGCTTGAACCGAACTGGGCACAGTGGGCAAATGTGATCCGCCTGATGCGCGAGCTCGACCAGCGCAGCCACCGGGATATCTGCGAGCTGTATGACTGGGTGAGCCGGGATGCATTCTGGTGCACCAATGTGCTGTCCCCGCAGAAGCTGCGCCAGCAGTGGACCCCGTTGACGGTGAGACGCAACGCCCCCACCCATCGGCCCGTCAGTGGACAGCATACCGACCTGACCCAATCCATGACCGCCGACGAGCTGAATCGCCGGATGCAGGAGGGCTTCTGATGAGCATGAAACCACTGAGCGCAGTGCTCGAGGACATGACGAGTTGTGGTCTTGCTGCACATGTCGGAGAGCAGCAGCAGCGGGTTTTGACCGACCACGACTCGCAGATGGTGTCGATGTTGTTCGAACAGTTGAAGATCGTGTTCCCTGCCTGGAAGCATGCTTTCCCGACCGATGACGCCCAGCGCCGAGCCCTGGCCGAATGGACCCGAGCTCTGGTGGATGCTGAGTGCACCAGTCGCGAGCAGCTGCAGCTGGGCATGCGGGTGGCTCGCGAGCAGGAGATCCCGTTCTTCCCCAGTACCGGGATGTTCATCAAGTGGTGCCAGATCACGCCGGAGTCGCTTGGACTGCCGACGGTCGATCAGGCGTTGGCCGATGTGGTACGCCACCGTAAGAGCCACCCGGCCGTGGTGATTGCCGCTCGCGCTACCCGCTTCGAACGCCAGACGCTGACCGCTGACGAGTACCGCAAGGTGTTCGCTCAAGCCTATGACCAGGTCGTGCGCCGTGTGATGGCCGGGGAGGATATCGAGGCGGAGGTGCTGAAGGGGTTGCCCACTCGTGAGCAGATCCGCCACAGCCCCGAGTTCTACCAGCAAGCTGGGCAGCGCGGCGTCGCCAGCTTGAAGGCGTTGTTCAAACGCGGGGGTGGTGCGTGATGGCCAGTCAATTCAATGCGAACGTCGAGCGCGATGTCCGTGAGGCGCAGTTCTGCCGGGTGGCCATCTATCCACCGGTGCGGGGCTGGGTGGGGGAGCGGGTGCACCTGGAGGTGTCGAATTCGCTGGATACCCTGGGCAAGACCGATGCCGCCACCGGCGCCGGTTATTACCTGGTGTGGGATGGGGCCGAGGAGGCACGGGCAGAGGCTGCGCGGATCCGGGGCCAGGCGGTGGAGCTGGTGAGGGTAGGGGGATGATGCACTACTACGCCCAGCACACCCCGACCCGGGATTGGCAAGCGCCGCTGCTGGGCATCGAGGAGCTGGCGAAGGCCCAAGAGGGTGGCATCTGTGTGTCGATCGGGATGTGGGTGATCCACGATATCGGGTTTGGTGCCTGGAGCACCGAGATAGGCGTGATTGTCGGGGCTGCCATGCACAAGGCAGCCCTTCAAGCCACCACCGGGAGGGGGAGGAAGGGATGAACATAGGCATGCTGTTTGGGATGTTGATCGTCGGCTGGGCGCTGCTGCTGGCCGTGTTGCTGGTGCTGATATGGGTAGCGCTGCGGGCATGGCGGGAAGAAGTGCAAGAGGACGAGGCGGCGTTACTGGATGAACCACGGCTGGTGTCGGCGTGCCGTGAGCTCTCAGAGCTGGCGGCGAAGACCAAGGAGGCCAGCCATGGCTAAGGCCTTCTTCGTGCTGATGTACCTGTTCGTGGCGCTGTTTGTGCTGGCCATGGTGCCCTATGAGGGGGGTATGGGCTGGCAGATGCTGCAGGCGCCGGTGGTGTGGGTGATCCTCGCGGGCTGGGTGTTGGTGATGTTCCCGTGCCCTGTGGTGCGCCTGCTGCTGGCACCGCTGCGGGCCATCCTGTTGCTGCTGGTGTGGTTGGGCACTCTGCTGCTGGCGATCACCAAGGTGGTGCTGGTGGCGCTCAACCGTGTGAATCGCGATCTGGCCGGGGAGGCCCATCATGACAGTTAAACCGAAGGAACTGAATGAACGTGGCCTGATCGACCTGGCCGGGGTGAAGGTGTATGTGGCAGGGCCCATGACTGGCCTGCCACAGTTCAACCGGCCTGCGTTCTTTGCCGCCGAGGCCTACCTGCAAGGGCAGGGGGCCAGGGTGATGAACCCCGCCGTGCTGCCGGATGGCTGGGATCATGATGCCTATATGCGGATCGCCATCCCGATGCTGATGGAGTGTGAGGCGGTGGCGTTTCTGCCCGGCTGGCAGCAGAGCAAGGGGGCGCGGCAGGAGTTCACCCGGGCTCACGCCTTCGGCTTGGTGCTGCTGCAGCTGGACGTCGAGGAGATCCCCCTGGGGTTGCTGGTCAGGCAGCATCTGCCGTTGATGGTGTAGGTCATATCCCGCCGTGAGAACATAACAAACGGTGATTGATGGCTGTATAAATACACAGTATCTTTTGGGGCTATGCCAAGGACATGACAATCGGGAGAGTGACATGCAGGTGTTGAGTTTTGACAGTATGGAGTTTGGCAAGGTGCGCCTGATCGATGAAGCCGGGCGCGTGCTGTTCTGTGCCGTCGATGTGTGCAAGGCGCTGGGCTACAGCAACCCGAGGGATGCGGTGAAGCGCCATGTGGACGAGGGGGATGTCGTGAAACGCGACACCCCCACGACCAGCGGGATGCAGGAGGTCAGCTTCCTGTGCGAGAGCGGGGTCTATGCCCTGATCTTCGGCAGTAAGCTGCCCGCGGCCAAGGGGTTCAAGCAGTGGGTCACCGGTGAGGTGCTGCCCAGCATTCGCAAGACGGGGCAGTACGCGATCGGCCAGTCCCCGGTCATCAACGTGGAGGCGGTACAGGTCGAGCTGCTGTTCGTTGAGACCGCGGCCCGCATGCTGAACGTCAGCAATTCCGGCAAGCTGGGCATGCTGCAGACCATCCAGCGCCAACACGGTCTGCCTAACCTGCTGCCAGCCTACGCCATCGACGCGCCGAGCGATGCCACCGATGGCAGTTCGCGGCCGACCTTCTCGGCTACCGAGGGGCTGAAGCAGCACGGGGTGAGCATGGGGGTGCGCTACTTCAACGCCCTGCTCGAGTCGAACGGGTTGCTGACCAAGATGCGGCGCCCCTCCACCAAGTCACCGGATAAGCAGAAGGAGTTCTGGGCGATAACACCCAAGGGGCTGCTGTACGGCAAGAACATCGTGGATCCGCGCTGCCAGCGCGAGACGCAGCCGCACTGGTACCAGAGCAGGTTCGCCGAGCTGCTGGCCAAGGTCGGGTTGGGGAAGGTGGCGGCATGAAGACAACCATATCAACCAAGGAACATGCAGTATGAATAACCCCAAAAAGGTCGCCGTCGTGGATATCGAGACTCTCGGCCAGGGTGTGGATGCGGTGATCGGCACCATCGGAGTGGTCATTGTCGATGTGGGGCAACTGCGTGCTGTGGATGAGTTCTACTGCCGGGTCGATCTGGCACAGGGCCGCCAGCGTGACGACGACACCCTGGCTTTCTGGGAACGGCAGAAGGTGGATAGCCCGGCCGCCTGGGAGGAGATGTTCGGCAATGCCGGTCGCCTGTTCCTGGTGGATGCGCTGCAGGCGTTGGCCAACTTCCTCGGACGCCATTTTGAGAAGGTGGCAGCAGTCGAGTTGATGGGCAATGGCAGTGAGTTCGACAACGTGCTGTTGACGCATGCCTATCAGCAGTGGGGAGTTGAGCAGCCCTGGTGGTTTCGTGGCAACCAGAGCCTACGCACTGTGGTCTGGATGGGGCGGCAACTGCTGGGTATTGACCCCAAGTATCAGCTGTCTTTCGAGGGGACCCGCCACCACGCTCTGCACGATGCCCGCCATGAAGCGGCATACCTGATCCACATACTGAACGCCTTCAAGCAGGGGCTGGCAGGGGTAGTGAGCGCTGGTCATGACATTCAATCTGGCGCTGCTACCTGATCAGGAGCGTCAGCGGATAGAGTTGAATAAGCAGGCGGCTTTGCTGGTTTGGCAGTGCCGCCGCAACCTGGCGACCCGAGAGGATGTTGCCAGGGCAATCATCAATCAGCCCGTGGATAACCAGGAGTATTTTCGCGATCGGCTGAACCACTACCGTGAGGTAAAGGGGTCACATGAGCAAGTTTACTAGCCGCAGTGCGGCCAGAGTGCAGCACCTGCAGCAGCAGGCCAGCAACCCGGTCGGGGCTGCCATCAATGCCAGCGCCGAGCTGTTCCGTTCTATCGACACCGCCTGCCCGGGCATGACTGCCGCGGAGGCTGCCCGTCGGATCATTGCCTCAGAGTCCCTCTCCGTGCGCCGCACCGCCAGCTATCAGCTGCTTGCCCGCCTGGGCCCGCTGCTCGACAAGCTGGAGATGGTGGAGAAGCTGGGATGATGCCGACCCATCCGGTCTTTGTGCCAGAGATGGGGATGGTGCTGCTGAAGGTAGGGGAGGGGCTGGCACAGCTTCGCACCTCCCTGGCCAACCGCCCGGCGGTACTGGTTCCTGCACCAGACGGTGGCGACCTGCTGACCCAGTTCCCGGAGCTGGCCATTGCCCTGCTCAACCCTTCCATCGTCAACGCCGCCGGCGGCGAGCTGGCCTTGCGCAGCGTGGGCCAGTGCCTGATCGGCCATGGCTGTATCGGGGAGTCGGTCACCACCGAGATGGGGGGCCTGCCGCTCCCATTGTGCTGGCACCATGACAACGCATACCGGGATGGCCAGTTGCCGTTCAACCAGGGTGAGTACGCCGCGGCGATCGCCCGGGCACTGCTGACCCGGGTGGCTGGCTGGTGTGGGGTTGCCCTTGCCCAGTTGCAGGCACGGGATCTCTGCTGGTGGGCCAGCGTGTTCAAGGTGCAGCAGCATCTGCCGATCGCCGTGGTGCGCCACGCCTGCCGTTTGCCGCCGCTGGAGCCGGAGCGGTTGCTGGTGCCAGGACGCGGCTATCGCGAGACGGATGCCCGCTATCGGGTGAATCGCATCGAGCTGCTGGAGCAGGATCCGCTGGCCGAGCTGCGCGGCCGGCTGCGTATCAAGCCAGCGGTAAAGGCCATCGACCCGGAGCCGCCGATGCTGCATATCCCCCGCCCCAAGATGCGGCGCTGGGAGTCGGCCAACTATCTGGCGTTCGTCCGCCAGTTGCCGTGCGTGGTGACCGGCCAGACCGATGGCATCGAGGCGCACCACGTGGTGGGGCACGGGCTCAGCGTGATGGGCAGCAAGGCCCATGACCTGATGACCTTTCCGCTCTGCCACCAGGCACACATGGAATTGCACAACAAGGGCTGGCAGCAGTGGGAGCAAGCCCACGGCAGCCAGCTGGATCACGTCGTGATGACGTTGAACAAGGCCGCCGGCCTGGGAGTGTTTGGATGACGCCATATAGTGGAAGTGGGGTGAAGGCGCGGGCCCGCCCGCAGCCGGTACCGGGATCCATGAACAAGACCGAGGAAGCCTATGCCGCCCACCTGCGCACTCTGATGCTGGCGGGCGAGGTGCTGCACTACGAGTTTGAGCCGCTCAAGCTGCGGTTGGCCGACAAGACCTTCTACACCCCGGACTTCATGGTGGTGCGCCGGGATGGGCTGATCGAGCTGCACGAGGTGAAGGGGTTCTGGGAGGACGATGCTAGGGTGAAGATCAAGGTGGCCGCCAAGCAGCACTGGATGTTCACCTTCGTCGGGGTTCAGCGCAAAGGCGCCCACTGGTCACTGGAGGCATTCTGATGCGACTCGAATATGCGCTTTCGATAGGGGAACCCCGTTCGGCGATGATCCAGGCCATCCAGTCCCGCTCTACCGGGCCTTCTCACTTGACGCAGGCCGATGTGCTGGGGGCGCTGGGGCTGGTGCAGAAATATGAAGGGGTGGGGTTGGCACTGATGATGGCCCGCTACACCAAGGACAAATCCAGCCACCACAAGGCTGTGATCGGGGTGATGGCCCAGTGCAGCAAGCTGGCACCCAAGTATGTGGGGGCCATCAAGGAGCGTGGCCAGGGGATGGCCCTGAAGGCGATCGCCGCGCTGGCGGTGCAGCACTATTGTCGCACGGTGGATACCCCAGGGGCGGCCTGTCACCCGCAGTTCTGCCATGGGCGGGGGGTGATCCGCGACCTGGAGCTGAGCCGCCTGCACGGCAAGGCCGTCGACAAGGTGTGTCCGCGCTGCGGTGGTACCGGGCTGCGGCCCATCCCCGGCACCCAAGTGCGCCGTGCCATCGAACCCTTGCTGGGGACGCTTAGCCGCGGCGAGTGGGAACGGCAGTGGTACCCGCTCTATCAAGCGGTGCTGGCCTGGTGCCATGTGCAGGAGAGTGAGGTGGATACACTTTATAAGAAAATGATTGATTTAAGAGAAGAATCAATGATTTAGGCGCAAAAAAAGGAGGCGTAGCCTCCTTTTTTTAGCAATCTACTCGTGCATTAGCACGCGACATCTTGCCAGGCAGTGTGCTCTGTACCGAGATATCGGAACAGACTTTTGTTTTCTGATACCAATTTGATAATAGCTTCATTTTGCTTTTCAAATTTTACCAGAGGACCGCGGCCATTTGCATACTCCGAAACCACAGCTTCCAGTGCTTTCATGAGCTCACGATTTGCCATAGCATACTCCAAATAGTCCACACTATTGGTGGTAAAAGTGTACACCCTGTTAAGCTAACGTGTTAACAACGTGTGCGTAAAAAATTTTAAAAATTAAGGGGGAGTAATCATACCGATGGAAAAGCCGATGGTCAATTTATAAACCATTATTCCTGTAGGTTACCACAGCGGGGATTCCTTTCGTGTAGTTATCTACATGGTTAAATCCAACGGCTTTGAAGGCGATGATGTCACATGGAGCTGGTGATGTAAATGCGAACTGTTGTACCTGGATCTCATTTTGAGTAATGCGCTCCATACCTAAAGATAGGTCGTCAAGTGAGGCTGTTAAGATGGGGAGCCAGTACACAACAATCTCATCTGGAGCCATTCGGCTGACTTCCCAGAAAGTGAGGTCGATGCTGACATTTGTCATATACCCTACGGCATAAGCAACAGGAGCACGATCGTAGTAGACAACGAGACGAACTGGCATTCCGAGGCCAGAGGTCATCTCGATAGGCATGATGTCAACTGGGTTGAATGTGAAGTGGCCAGCACCTCGGAATGCCGCAATGTCCTTCATTGCTTGTTCGTCACCAACGCCAATAGCCAGTTGCTTCGGCAACTCTAGTTGCCCTCCAAGGATCGTACCAGTGAAACCGAAGACAGATCGTTGAATATCAATAAAATCAGCATTTCGAATATTACTTGGATTCATTGTCGTCCTCGATTTTCCTAGTCCTGTCATTGAGATTCATGCATTCTAATCAGGTACATCTGAGTCGGCAATACGCCATGGTTTTTATATTTATACTCAACGATGTATGGTGTCATATGAGGTTGAGTTTGGCGGTGGTGAACCATGTATGAAATCAAACATCAGGTGACTATTTATGCATGATTTAATTGTTTACACTCGATTGATCGAGGCTGTGAATCGTTTACTGTCAACCTACCCAGTTGATGGTGTCGGAGTATTGGCGTGGTTGGAGGCTGCTGATGTCGAGGTTCAACAGAAAGGAGGTGACATCACTGACGTACTAGTTGCGTGGTCTGAATCTTCAAGCCTAACTGTATGTTTTGACTGCGAGTCTAGGTTGGTTGTGTCTAGTTGAGGTTGGTGGCTTTGTGTGGTGGGCATATTGGCGGAATTGCCTATGCCCAGTAATTTGACATCCTCGCAACTTAAGGTTTCTGGCTGGGGTTCTCACACGGTCATTTTTCTACCACTGTGCTGTAACTTAGACATTTGAAATCCCGCTTCAGGGCTCGGCGCCCCCCTTTTGCGGAGCTTTAAACCTGAACAGCCTTCATCGGGTACAATGTGGGTCCCATATCGTCCAGGAGCGTCCCAATGTCAGCTCTTATTCCTGAACTGATCGCCATGGCCAGTGATCCCGCAGTGGCCACTTCTGATCTGCTACGCCGCGCTTTTGTGGCTGCTCACCGCTTAAATCTGCCAGAGTGGATCGATTGGATAACACATGAGTTGCAGGGCTACCCTGAGGGGGTGCCGTTGCCCCCATATAGGCAGCTTCAGGGAGAAATAGTGGCTGACCACCCTATGCGAGGTTTGACACAGGTATCATTCTCATCTGCGCAGAGTGCAAGCGAATGGGGGTTTTGCAACCTGGACACTCCTGTGGAAGAGATCGAGGGGTGGATTAATGAGGGGGATGATGTGGTGATGACGTTTCCCCCTGGGGCTGAAGATGCTTTGAGGAAGGCTATACGCCCTTCTTGTCGTCCCCTTCGTCGTTTCCACCTGAGCATGTTTAAAGCGCTGATCGGCGCAGTCAGAAACAAGGTGCTGGACTGGGCTCTGAAACTGGAAGGTCAAGGCATCCTGGGTGAGGGATTGAGTTTTACCGCTCGAGAACAGGCTCAGGCCCAACAGCTGACACCGGTGACCCACATACACATCGGCCGGGATTTCACCGGTGGCCAACTGATGGTGAGCTCACCTGGTGCTCAGCAGCAACAGACCATCACAGACGAACAGAAAAAGGCGGCCTTAGCGGCCCTGTTGCCGTGGCTGCAGCAGGTGATCGCACATGGGCAACTGCAGCAGGAGGTCTGTGCAGAACTGCAAGCAGAATTGGACACGCTCAAGGCACAGGCCGCCTCTCCAAAACCCAAGTGGCCGGTGATCAGTGCCGTGGCCAGCAGTGTGCGGGAGATTCTGGTAGGGGCAGGTGGTGAAGTGTTGGCTGCAAATGCGTTGGGCTTGTTGGCGACCTTATCTGCGGGTTAAGCAAGGCCGTGATGATTAAGAGTTTCTGTTGGTACATGTAAGAGGTTATTACTGAAGGGATGGGTAGCAAATTGGAAACGCCAGCTCTGAGGATGGCGGGCTGGGGGCTACTGTACGGCGATTTCTTCGACCTGTACGACGTTGTCGAAGTGCTTGAGATTCCCAGTGGCCTGGCGGGCCAACTCATGATTTACCTGCGCACGATGCGCTGTGTGGAGCTGGTGGCCGAAGTTCGTGTAGGGCTTAAAGAGGAGGGGAGAGCCCACAAACGGATTTTCATCAAGGTGCTCTGCATCCATCCAGAACCCCCCAGTAAAGCCCCCCCTGCCAAACTAAACGTCCTGCGCTCTAAGTTGGTTCATCTATCCAAGGTCATGCCTTCACCGCGGGGAGTTCGCTGATTCAGTTGATGCGGCGGGAGGATGGCCAAGGGCCATTTGGGGAGCTAGGCGAACGACCAAAGTAGGGCCGATCCCCCTCCTTTCAGGGCTGACGGGATCCTCCCCTTTGCAGCACTGCAAACTACACGGCCCAAAACGAGTACAATGGGGCCCTATTTCACTTAGGAGTGCCTCAATGCCCGACCTTATCCCTGAACTCATCGTCATGGCCAGTGATCCGACCGTCAAGACTCCCGATCTGCTACGTCGTGCCTTAGTGGCTGCACGACGGCTGAAGTTACACGAGTGGGTAAAGTGGATCGGTTATGAGCTCAGAGGATACCCCAATGAGCAGGAACTCCCACCGTACCGCGAAGTTAGTGTACCGTTAATGGGGCAAGACAATCTTGGGCAGCTCTGGCCGATCACCAACCCTGCATTATGGAATCTAGGTAAGTACCAGTCTGTTGCTATCAAGCAGCCGATCGGTGAGATCGAGGCGTGGGCTATTGGAGGCATGGATATAAAGTTGAGATTTCCCGATAGGGTAGAGCAACAGCTTTTGGACTGCATTGGTCATGCTGCCCTCCCTGTCCGTGTACTAACGATAGGGAGCATCAGCAGCATCCTCGACATGGTGCGTAATGAGGTTCTGGAGTGGTCACTTGCATTAGAGGCAGAAGGAATCTTGGGAGAAGAGATGAGTTTTACAACGCAGGAACAGGACCAGGCCAAGCAGTTGGCACCGGTGACAATTCACATCGAAGGGGGGATTCACGGTGGCCAACTGATGGTGAGCTCGCCCGGCAGCCAGCAACAGCAGACGGTGACCAGTGAACAGAAGGTCGAGGCACTGGAAGCCTTGCTGCCTTGGCTACAGCAGGTGATTGAACAAGGGCAACTGCAGAAGGATGCCTGTGGTGAGTTGCAGGCTGAGCTTGCGACCCTCCAAGCTCAGGCCGCCTCACCCAAGCCGAAATGGCCGGTGATCGGCGCTGTGGCTGGCAGTGTGCGGGCGATCCTGGAAGGGGCCAGCGGCGGGGTGCTGGCTGCAGAGGCGTTGGGCTGGTTGGCTACCTTGGCTACAAGCTGAGTGATAGGTTTTCTGCATGCCACCTGCCTTTATACCTTTACTCTCGGAAGCTCGTTAATGCAGGTGGTATAGCGGGGACTGAGCTGATCTCGCTTCATCATCCACTCGCTGGCGTCCCGGCCCCTGGCGGCAAAGTAGACCTTTCCCAACCTTCCCTGATTTATCTGGTCAATCACCTTCATCAGAGCCTCGCTGCGGGGATCCTGCTGCTGGTCAGCGAAAAGGTCTCCCTGGTGCATGCTGGCCGGGGTGAAATCGGCCAACATGACGCCCCCCTTCATATAGCGGACATCATCTCGCCAGATCCGGCGCAGCAGCGGCTCAACCAGGGCCAGCAGGTCACGGGTATCTGAGGTGGGTGTCTGCAACCGGGTCGATACCTGGTTGCTGTAATAGGTCTCTCGCTCCGAGAAGGGGCTGCTCCTTATAAAGAGGGTGACGTGCTGGCAGCACATGCCCTCCGCTCTGAGCTTTTCCGCGGCCCGCTCCATGTAGCCGGCCAGCGCCTCCAGCATGGGGCCAAACGCGGTGATGCGCTCACCAAAACTCCGGCTGCAGATGATCTGCTGCTTGGCCTGGGCCATCGGCTCCAGCTCGGCACAGGGGATCCCCCGTAGCTCCTGCACTGTGCGCTCGACGACGACCCCATACTGTCGACGCAGGCTCTTGGGGTCGGCCGCCACCAAGTCGGCCACGGTGTTGATGCCCTGTTTGTTGAGCTTGGCTGTCAGTTTGCGCCCTATCCCCCAGACTTCCTCAACCGGGGTGATGGCCATCAGCTTGGCGCGGCGCCCCTCATCGCGCAGATCCACTACACCGCCGGTGGCGGGCCACTTCTTGGCGGCGTAGTTCGCCAGCTTGGCCAGGGTCTTGGTCGGTGCAATGCCCACCCCGACGGTGAGGCCGGTCCACTGCTGCACCCGCTCGCGGATCTGGCGGCCATAGGCCAGCAGGTCACCGGCCCAGCTTTCGCTGAGCTCGACGAACGCTTCATCAATGCTGTAGACCTCGACGGTTGGGGCCATGCTCTCCAGGGTGGTCATCACCCGGTTTGACATGTCGCCGTAGAGGGCGTAGTTGGAGCTGAACCAGATACCGCCCTGTTCCTCATAGAGCTCGCGGATCTGGAAGTAGGGCACCCCCATCTTGACCCCCAACCGCTTGGCCTCTGCCGATCTGGCGACGACACAGCCATCGTTGTTGGAGAGCACCACGATCGGCACCCCCTTGAGGTCGGGGCGGAACAGACGCTCACAGGAGGCATAGAAGTTGTTCACGTCGACCAGGGCAATGGCGGTTGGCATGGCTACCCTCGCCGGGTTTTGTGCAGAACGAAGGTGACGACGCCGAATATATCCAGCTCCTGCCCTTCTTGCAGAATGATGGGGGCGAAATCCGGGTTGGACGGTAGTAGCGCGGGTGGGTCGGACTGCAAGATCTTGACGGTGAACTCGCCATCCAGGCAGGCGAGCACGATGTCGCCGTGGCGAGCCGTGATGGCGCGGTCGATGATCAGCATATCGCCGTCGTTGATGCCTTCTCCGACCATGCTGTGTCCGCTGGCCCGCACATAGAAGGTGGCCGCCGGGTGGGGGACACAGTGTTGATTGAGGTCGATGGACTGTTCCACATAGTCCTGAGCCGGGGAGGGGAATCCGCAGGCGGCAGGGGTGAGGAATAATGGGATCTCTATGATAGGTGCATTGGTTGCGTGGGGGAGCATGGTAAAGGTCACTGTATGAACATACAGTGATTCTAACCGAGGGATCCGGAAAGATCACTGGTCGTCGTTCGGGTCTTGGCATGGCAAGGGGGACGCGGCCAATTATGCTTGGCAGAGACTGACCAGGTGAGTTTGAGCTCTCATACGACGGAGGGGCAGCGCATGTGCATCAACTACATCCCGACCACCAAGGCGGTGCTGGTGGAATACTTCGGAGTTGATGATCCCGGGTTCGGCTGGAAGGAGGAGGTGTGGCAGGACTACCTGGCCCCGATCCTGATCCAGCGAGACGGACGGCGGCAGGCGCTGATCGCCAGTTATGGGATGGTGCCCAAGAGGAAGGTTCAGCCAGGCAACAAGCACTACACCACGATGAACGCCAGGGCTGAGACGGTGGGTGAAAAGCCGACCTACCGCCACGCCTGGCAGCAAGGGCATCTCTGCCTGGTGCCCATGTCCGGTTTCTTCGAGCCCTGCTACGAGAGCGGCAAGGCTGAGCGCTGGCGGATCAGCATGGCCGACGGCAGGCCCTTCGCGGTGGCCGGCATCTGGCGGGCATGGCAGGAGGAGCAGGGCTACACCTTCAGCTTCTCCCAGCTCACCATCAATGCCGACACGCACCCGCTACTGCGGCGAATGCACAAGCCCGGAGACGAGAAGCGTAGCCTGGTCATCGTGTCGCCGGATGACTACGACACCTGGCTGGGGTGCAAGGACCCTGAACTGGCGCGAACCTACCTGGTGCAGCAGGATATCTGTCAACTGAAGGGAATATCTATGCCGATCCCGTAGAGTCATTGAACAGGGTCTTGTTCTGGGTAGCAGATATCTTACAGGTAAGCTGTCGCCTACAGCTTTACTAGAAGTCTAGGTTGGCGGACTGACTGGAGTACGATGAATATCAGTACTATCCAATGATATTGGCTAGATGCTATCAGCGGGAGGTGGTTGGGTATTCTACGAGCAGATGATGGCTCAAGTGGTTTAGGCCAGGCTTCACTTGCTCAAACAACTGTAAAGGAGGAGAGAGGGGACAAAGCCCCTCTCTCTGATTACTACGTCTTCCTTTTCGGAAAAGGCAAGAACATTGGCGTCGTTCCTATACTGCCATCTTCCGCTTCGCACTTAACAAAGCCCAGTTTTTCGTAAAATCCGATGGCCCCAGGGAGTGCATCGACAAAGACTCCAAACGACCCAACCTGCTCTGCTGATGCTAATGCTATCTCGACAAGATGCCCTATAAAAAACGAGCCAACACCTTGTCCAGCATAGTCTTTGTCAACTGCGAAGCGTCCTATTAGAACAAAAGACACTTCTCGGTACGGAAGACCTTTACCAAATGCACCTAGCTTCGATTTTTCAATCTTGGTTGCGGACATGGTAGCGAATGCAATTACTCCGTCGCTGTCACTAACAACCTCGTGCCCTGCTAGTACATTTTTTTGCCACTGCTTTACAAATTTCTTGTGGTAGAAGTCATCCAAAGATGGCTCACCACTGGAAAAATCAGCATCAATCTTGCCTGAAAACGGCTGTACTCTTACTTCTAGTTCTTCGTTCAATCTTCAGTACTCCACTACGGGAGCTTTCGATAGCCGCGGTCATTCTTGTGTTGAACTCTGGCGGATTTGTCAGAAGCTCGATCATCTTGGCATAGGACTGAGTGGTTAACCTCAAAGTCCGTTCGCTTTCGATAATCTCTTCGGCAACCTTGCGTCCTGCCATCTTGACGAAAGCCGACACACTGACACCGCTGATGCTTGCTGCTTGCTCGAACAGCTCTTTTATTTCATCAGTTACCCGAAACTCGAATCGCTCTTGTTTCGGCCTCTTCATTGCCGAACTCGCTACTGCGTTAGCGGCATTTTTCATAACGTCCTACCTCTAAATCGTCTTATTCACCTCGATGGGCGATGCGATGATATTTGTATTTATCTATGCGTATAAAACTCCTTATTCAGGGCTCATATAGGACCCTATTCTGGTGTGTTTTCATCAGTTTCTCCCTACTTGCAATGACTGGTTTCTAGTTAGATGGACGTTCCTAGAGGCTTTGGGTCACCCTATGAACGCCTCATTTTGTCCGTAAATTTACCGGACACAATGATGCTATCATCGACTTCAAAAATCGTCAACTAAATTGTTGACATGTGAGTTTATGTATGAATTTTTGTCTCAGAATGTCCCCGGATTTGGTCCATAGCCTAGGTTTTAGCCTGCTCAGAGCTTCTTGAGCTACTCGGTTACTGATATGGAGAAGTTGGGGTGGCGTGGGGACAAGTATTTCCATCACAAAGTACAGTGTGTTGACAGGGGATTGCACAATTGTGTAAGTTAAAAGCTAATGATGGAGGACTGCACCCGAAAGGGTTCAGTCCTTTTTTATTCCCCTTTCAAACCTCGGCCTTGCCGGGGTTTTTTCATTTCTGAGTCCCTGCGGGGTGGTGGGTATGCAGATGCCTGATAAAGACCTTGGTCTGTTGGCCTGGCTGCTGGCGTGGGCCGATTCTCACTGGCCCGCGCTGTATGGCTTCATTCTGTCCGTGGTGATCTCCTGGTTGCGGGTGACTTACTCCGGCGGCGGTGTTCGACAGCGGCTGCTCGAGTCGCTGCTGTGTGGCGCCATTTCTCTCTCAGTGATGTCTGGGATGGAGTTGTTTGGGATTGCGGCCACCGCATCTGGGTTTGTAGGCGGTTCGATCGGGTTCCTCGGGGTCGAGAAGATCCGTGAGTTTGCCGGTCGCGTGCTGGATAGGAGGTTTGGCAATGGTCCGAGTTGAGCGCACATCACCGCACGGCATCAGCCTTATGCACTACTTCGAGACCTGCAAGTTGAGGGCCTACCCAGACCCTGGCAGCAAGAATGGGGAGCCGTGGACTATCGGGTGGGGGCACACAGGGCCAGAGGTGAAGCCCGGGCTGGAGTGGTCGCAGCAACAGGCTGACAGCGCGTTCGTTGATGACCTCCGCCGCTTTGAGCGTGATGTGTTGTCGCTGGTCAAAGTGCCACTGACTCAAGGCCAGTTCGATGCACTGGTGTCGTTCGCCTACAACGTCGGTTCTGATATCGATGCCGACACCATCCCGGAAGGGTTGGGAGATTCCACGCTGCTGCGCAAGCTGAACACCGGTGATTACGATGGTGCAGCCCGTGAGTTTCGGAAGTGGAACAAGAACGATGGCAAGGTGATGCGCGGGCTGACCCGCCGGCGTGTCGCAGAGGAATGCCTGTTCAGGGGAATGGATGCCGCTGCGGCCATCAAAAATGGGGTAGCTGCAGCATGAACCCCGTCAGGCAGTTCCTCAATGCGTATCCCGTGGTGTGGTTCTTCGCTCGCCTGACCGCGGTAGCGCTGCTGGCGTGGTGGATTCACCACTCAGGCTACAGCTCCGGAGCTCATGACAAGGGGCTTGAGTGGTCAGAGAAGTGGAACAAACAGGCGGCCGAGCTGGCCACTGCACGAGCGGATGCGGTAACCGCTGCGCGAGAGGTTGAGCAGCGTCGCCAAGCGGACATAGAGAAGGTGAGACAGGATGCAGAACAAGAGATTGCCCGGGCTGAGAGTGACGCTGCTGCTGCCAGTGCTGTTGCTGCTGGGTTGCACGAGCAAGCCCGCCGCTTGGCAGCACGAGCAAATCAGTGCGCCAGCCATACCGGTGCTGCCCAGCCAGGCGAAACAGCCAGACAGCCCGCCGTGGTGCTCGCCGACCTGCTCAGCCGGGCTGATGCGCGAGCGGGAGAGCTGGCAAGAGCGTATGACCGAGCTCGAGCCTCCGGTCTGGCCTGTGAAAGAGCCTACCACTCACTGATTTCCCAGCAGTAACCGAATCGCCGCACCGGGTCACTCTCCCACCTGGCGGGTCGTCCCGCGTTAATGTGTGCCGGTGCGGCACCAACCAGGTAGCAGCCATGCCTCTACGAGTTCCCAAGGTGTGCAGAGAGCGCACCTGTCACCAGTTGACCACCGAGCGGCATGGCTACTGCCCAGCCCATATACATCTGCTCGATGGGTGGAAGACGGTGGCCAAAGTCAGCGCCGATGAGCGCGGCTATGACTGGGCGTGGCGCAAGCGACGCAAGCGGATACTGGAGAGGGACAAGTACCTGTGCCAGGTGTGCCTTGCCTTGGGCATCGTGACACCAGCGACTCAGGTCGATCACATCGTCAACAAGGCCGCTGGCGGCACCGATGATGACGATAACTTGCAGAGCATCTGCGACCCTTGCCACGCCACCAAGACGCGGGCAGAGGCGCTGGCAGCCCGCCGGGCGGGGCGGGGTAGGGGGTAGGGGGGATCAAATCCTCCCAGCTTTGCGACCTCACCACTGCTCCGCCCCGCGAAATTTTTATACCCGCGAAATTAAAAATTTAAATGGAGGGCGCGATGGCCGGTGCAGCTGCCGTGCCCGGGCGCGGCAGAAAGCCCAAGCCGACCGCACTGAAGCGCCTGGGAGGCAATGCCGGCAAGCGGGCACTGAATAAAGACGAACCCATCTTCACCCCTCTCATCGGGGTCGCCTGCCCTGAGTGGCTGGCAGAGGATCCATGGGCTCCCACGCTGTGGGATATGGTCATCAAAGAACTGTGCGCCGCCGAGGTGCTGTGCATCACCGATCTGCACAACCTGGAGGCGTTCTGCGCCGCTTACTCCCGCTGGCGCAGAGCCGAGATTGAGATCACCAAGCACGGCCTGGTGGTTGAAGGGGCCACTGGTGGTCCAGTCAAGAATCCGGCCTGTACCGTCGCCAACGAATCACTCAAGCAAATGACCACATACGGGGCCATGCTCGGGCTGGACCCTTCCAGCCGCTCGCGCTTGATCGGCGGCAACAAGAAGAAGGGAGGCGGCAACCCGTTCGCTGCTTTGTAGGGATAGACCATGGCCGCACGCAAAAGCTATCCCTACGTCAACGTGGCCAATGGCTACGCCCGCGACATAGTGCGCGGCAAGATCCCTGCCTGCCGCTATGTGATCCAGGCATGCCAGCGTCATCTCGATGATCTGGCCAAGGAGAAGTCGGCCAAGTTTCGCTACCGCTTCGACAAGGACAAAGCCGAGCGGGCCGCCAAGTTCGTCCAGCTCATGCCCCACACCAAGGGGGAGTGGGCCTTCAAGCGCCAGACCCTGAACCTTGAGCCGTGGCAGCTGTTCATCATCTGCTGCGTGTTCGGATGGGTGCGCAAAGGAAGCGGCCTGCGGCGCTTTCGCGAGGTTTACAACGAGATCCCCCGCAAGAATGGTAAGTCGGCGCTCTCCGCCCCGGTTGGCCTCTACTGCTTCGCGGCGGATAACGAATTTGGCGCCGAGGTTTACTCCGGCGCCACGACAGAGAAACAGGCGTGGGAGGTATTCCGCCCGGCCCGCCTGATGGCCAAGCGTACCCCGGCGCTGCTCGATCATTACGGCATCGAGGTCAACGCCAGCAACATGAACATCCCTGCTGACGGCGCCCGTTTCGAGCCGCTGATCGGCAACCCTGGTGACGGCCAGTCACCATCCTGCGCCATCGTGGACGAATACCACGAGCACGACAGCGACGATCTCTATACCACCATGATCACCGGTATGGGGGCCCGCAAGCAGCCCCTGATGTGGATCATCACCACCGCGGGCTACAACATCGACGTGCCCTGTTACGACAAGCGGCGGGAGGTCATCGAGATGCTGGCCGGCACAGTGCCGGACGATGAGCTGTTCGGGATCATCTACACCATCGACGAAGGTGATGACTGGGCAGATCCTGCGGTGCTGGCCAAGGCCAACCCCAATATGGGGATCTCGGTCTACTCAGATCACCTGCTGGCGCAGCAGGCCAAGGCAATTAAGTCGGCCCGCTTTGCCAACATCTTCAAGACCAAACACCTCAACGTCTGGGTCTCGGCCAAGACGGCGTTCTACAACATGCAGCGCTGGGCGGCCTGCGAGGACAAGAGCCTCACCCTTGAGCAGTTTGCCGGTGACGAGTGCATTCTCGGCTTCGACCTGGCACGCAAGCTCGACATGAACTCCATGGCGCGGTTGTTCTGGCGCGATATTGACGGCAAGCGCCACTACTACTCGGTCGCCCCCCGATTCTGGGTGCCGGAAGATACCGTATTCGATAACGATAACCGGCGTCTGGCGGAGCGATACCAGAAGTGGGTCAACCTGGGTGAGCTCAGCACCACCGATGGGGCAGAGATCGACTATCGCGAGATCTTCGAAGAGGCCAAAGAGGCCAACCTAACCAATAAGGTGCTGGAGACTCCACTCGACCCGGCAGGGGCAATTGCCCTGTCTCACTCGCTGGCAGATGAGGGGATGACCCCCATCACCATCACCCAGAACTATCAGAACATGTCCGCCGGGATGAAGGAACTGGAGGCTGCGATCCAGGCCGGCCGCTTCCACCATGACGGCAACAGCTTGATGACCTGGTGTATCGGCAATGTGATCGGCAAATACCTGCCCGGAAACGATGACATGGTGCGCCCGATCAAGGAGAGCGCGGATCAGAAGATAGACGGCGCGGTGGCGCTGATCATGACCATCGCCCGCGCCATGGTGCCGGATCGCGGCGATGACCGCTCCATCTACGAAACCTCGGACGTTTTATGCTGACACAACTTTTCATTTTCATCGTGGGCCTGCTGGGGGCTGCGGCGCTGGCCTATGGCGCCAGCCTCTACGCCCCGCCGCTCGGCTGGATAGTGGGCGGTCTGCTCTGCCTGATCTGGTCATTAATGATGAGTCGAGCAGTGGCTGCCGCCGAGTTCGCCAAACGCCACAAGGGGGATAGCTAATGTTCCTGCCAATGATGTTCGGCAGCGGGCGCAAGGGCGGCAACTTCAGTCAGTGGATCAGCAGCATGGCGGGTAAGACGACCAAGGCCGGAGTGCTGGTAACGCCGGAGACTGCCCTGGCGCAAGGGGTAGTGCGTGCCTGTGTCACCCTGCTGGCCGAGTCCGTGGCGCAGCTCCCCTGTGAGCTCTACCGTCGAGATGATGACCAGCGGCTGCGTGCAACTGACCACCCGCTGTACGACCTCATCCATAACCAGCCGAACCAGAAAGACACAGCGTTTGAATTCAATGAGCAGCGCATGGGCCACCTGGGCCTGCGTGGCAACAGTTACAGCTTGATCGACCGGGATGGGCGAGGCTTCATCACCGAGCTCATTCCCATCAACCCGGACAAGGTAGCTGTGCTCAAGGGGCCGGATGGGTTGCCCTATTACCAGTTGCTGGATGGCAGCAACCAGATCTTGCCGATGCGGATGGTGCACCACGTCAAGGCGTTCAGTCTTGACGGCTACCTGGGGCTGTCACCAATCCAGACCAACCCTGACACCATCGGACTTGCGATGGCGGTGGATGAGCATGCGGGAAGGGTGTTTGCCAATGGCACGACTCTCTCGGGCGTCATCGAGAGCCCGAAGGATGGAGCCAAGTTTGACACACAGGCCAAGGTGGATGCGTTCCTCGGCAAGTTTGTAGAGCGCCACTCTGGGCTGCGCAACGCCTTCTCAGTCGCATTACTGCAGGAGGGGATGCAGTACAAGCAGCTCGCCATGAACAACGAGCAGGCGCAGCTGCTGGAGTCCCGCAAGTATGGCGCAAACGAGATCTGCCGGCTCTACAAGGTGCCGCCGCACATGATCGGCGAACTGGAGCGGGCGACCAACAACAACATCGAGCACCAGGGGCTGCAGTTTGTCATCTACACCCTGCTGGCCTGGGTCAAGCGGATCGAAGGCGCCATGATGCGCGACCTGCTGTTACCAGCGGAGCGCAAGAACCTCTACATCGAGTTCAACGTCTCCGGGTTGCTACGGGCAGATCAGAAGTCCCGCTACGAGGCCTATGCCCTCGGTCGCCAGTGGGGCTGGATGAGTGTCAACGATATCCGCCGGCTGGAGAACCTACCGCCGGTAGCAGGTGGAGATATCTACCTGACTCCGCTCAACATGGTGAGCACCGGCTCCCTCCCGCCAGGCATCACCAAAGCCAGCGCCGAACAACTCAACGATATCGAGGCCATCCTATGCCGAAGCTGATCAATTACCCCCATCTGGCCAGCATGGCGTTTGGCCAACCACTCTATGCCACTCAGGATGTTCTGGCTGGAGTGAAGAGCCTGCTGCTACCACGCATGCTGGGCAACCATCGAGACATCATGGCGGCCGACGAGTTGCCGGACGGGTTCGAGCCTGCTCCGCTGGAGGCCAAGGGCGAGTTCAAGAACCGCATCGGCGGGCTGGCTGTGATCCCTGTACACGGCATCCTGATGGCGCGGCGTGGTCACATCGATGCCACCTGCACCGAGCTGACCAGCTACGAGTGGGTGAGGATGCAGATCGCCACCGCGCTGGCTGACGAACGGGTCAAGGAGATCGTGCTCGACATCAACTCTGGCGGCGGCATGGCGGTGGGCTGCAAGGAGCTGGCGGAATACATCTATTCCAAGCGCAGCGTCAAACCGATTACCGCCCTGGTCAATTTCGCCGCCTACTCGGCCGCCTACTTCATCGCTGCTGCTTGCACCAGGGTGGTGGTGAGCGAGACCGGCGGCTGCGGCTCGGTGGGCGTCATCATGGAGCACATGGAGGTAAGCAAGTGGGAGCAAGAGGTGGGGCTTACCTTCACCACCTTCTACCGCGGCGAGCGCAAGAAAGACGGCACCCCGCACGAGCCTCTCTCCGAGGGGGCGATGGCCGCCATTGACCACCGGATGGATCAGGCCTACGAGCTGTTCGTGAGTTCGGTCGCTCGATATCGCAGCTTGTCAGCAGAGCAAGTGCAGGCCACTGAAGCTGCCCTCTTCAGCGGCAGTGAAGCCGTGGCCAACGGCCTAGCAGACGAACTGGCCAATCCCCAGGATTATCTCAACGCCCTTGCCGCCAGCGTGGCCAACCAGGGTAAACCTCAACAGTCCGTAGGCCTGCGGGCCAGGGCCATCGAATTGCAGAACCAGCTCTAGCCCTGCGGCGGAGCCCATCCCAATAAGCCCCTTTTGGGGCTTTTTTTATACCCAAAGGAAACCACTCGATGAAAACTATCGAAACCCTCCGCCGCGAGCGTGGCGAAATCGTCGCCCAGATCACCGTCCTGGCTGATATCGAAAAGCAGGGCGGGACTCTGAGTGCTGAGCAGTTGGCCGAGTTCACTTCACTCGAGAGCAAAGTCGCGGAAATCAGTGCCCAGATCACCCGACTGGAAACTGCAGAGCGGCTGGCAGCTCAGCAGGCAGTGCCAGTCACGGCCTCTGCATCAATGATTGGCTCGCCTGCCGTTCATGTGAAGCAGGAGCTGAAGCAGTACCCCGGTGCTGGCATGGCTCGTATCGCCATGGCCATTGCTGCAGGCGAGGGGGACATGGAGCTGGCAGAGCAGTTTGCCGCCAACGAGATTGGTGATGCCGGGATTGCCATGGCTATCAGCACCGCGGCTGGTTCCGGCGGTGCTCTCATCCCTGAGAACCTGCACTCCGAGGTGATCGAGTTGCTGCGCCCCCGCACCATCGTTCGCAAACTCGGGGCCCGGCCGGTGCCGCTGCCCAACGGCAATCTGAGCATGCCGCGCATGTCCGGTGGGGCCACCTCCAGCTACGTGGGGGAAGGCGTTGATGCCAAGGCTACCGGTGGCAGCTTCGATGACGTGAAGCTGGCGGCCAAGACCATGATCACCCTGGTGCCGATTAGCAACCAGCTGATCGGGCGTGCCGGGTACAACGTCGAACAGCTGGTGCTGGGTGACATGCTCGCGGCCATGGGCGGTCGTGAAGACAAGGCGTTCCTGCGCGATGACGGCAGCAACAATACCCCGATCGGCTTCAAGAAAGTGGCCACCGACGCGGGCCGTACTGTTGCCTGGACCGGCACGGCGGATCTGGACACCATCGATGCTTACCTCGACTTGCTCATCCTGAAACTGATGAGCTCCGACTCCATGATGATCAACCCGGGTTGGGGCATGAGCCCGCGCTCCTGGATGAAGCTGTTTGGCCTGCGCGATGGCAACGGTAATAAGGTCTATCCGGAAATGGCCCAAGGCCTGCTGAAGGGCTACCCGGTTGCCCATACCAACACCATCCCGGTGAACCTCGGCGCGGGTACCAACCAGACCGAGATCTACTTCGCCGACTGGAACGACGTGGTGATCGGCGAGCAGGACAACATGACCATCGACTTCAGCCGCGAAGCCACCTATGTGGATGCTGCCGGCGAGCTGGTCAGCTCCTTTGCCCGCAACCAGTCCCTGATCCGTCTGGTCGGTAACCACGACGTGGGCTTCCGTCACGTAGAGGGGCTGGTGCTGGGGACTGCCGTTACCTGGTAAACCCTGCCATGGGGCTGCTTCGCGGCCCCTTCCATTTCCCTATCAAGACCGTTCAGGAGAGCCATCATGGCCAAACCAGACAAGGCGGGGAGCGAACCCACCGTAATGCTTATCAAGGTGATCCGCCCCTTCAAGAACTACAGCCCCGGCGACATCACCGGATTTGACGCAGCCAAGGCGCAGGCCTTGATCGACGGTGGCGTGGCTGAGGCCTACACCGCAGCCGAGGGTGAGGAGTAAACATGTTGCTGATCACCGTGGTTGAAGCCAAGGCTCAGTGCCGAATCGAACCGGAGATGACCGACGAAGATGCGCTTCTGACCGGTTTGATTGAAGCGGCGATCAGCCACATCCAGTCCGACATCAACAAGCCGCTGGTGGCAGCAGGGGAGGAGGGACAGCCCCTCACTCCTGCGCTCAAGCTGGCGGCCTTGCTACTGATCGGTCATTGGTACACCAACCGGGAGGCCGTGGTGACGGGCACCATTGCCACGACTCTGCCGCTGGCGTATGACTCGCTGATCCACCCCTACCGTGACATCGTGGTGGGCTAG

Protein sequences of DBSCAN-SWA_2

>NZ_LS483441|899788:947853|940890_941271_+|WP_042016756.1|DBSCAN-SWA
MPLRVPKVCRERTCHQLTTERHGYCPAHIHLLDGWKTVAKVSADERGYDWAWRKRRKRILERDKYLCQVCLALGIVTPATQVDHIVNKAAGGTDDDDNLQSICDPCHATKTRAEALAARRAGRGRG
>NZ_LS483441|899788:947853|915024_915234_-|WP_033130544.1|DBSCAN-SWA
MHQKVVVMERPSWVLPRVLGEMFGYTEKAISEKRKKGQLIEGVHYKLAPDGKYVYHWRRYEDWLTGTKN
>NZ_LS483441|899788:947853|930667_931315_+|WP_111736012.1|DBSCAN-SWA
MRLEYALSIGEPRSAMIQAIQSRSTGPSHLTQADVLGALGLVQKYEGVGLALMMARYTKDKSSHHKAVIGVMAQCSKLAPKYVGAIKERGQGMALKAIAALAVQHYCRTVDTPGAACHPQFCHGRGVIRDLELSRLHGKAVDKVCPRCGGTGLRPIPGTQVRRAIEPLLGTLSRGEWERQWYPLYQAVLAWCHVQESEVDTLYKKMIDLREESMI
>NZ_LS483441|899788:947853|925956_926217_+|WP_042016737.1|DBSCAN-SWA
MASQFNANVERDVREAQFCRVAIYPPVRGWVGERVHLEVSNSLDTLGKTDAATGAGYYLVWDGAEEARAEAARIRGQAVELVRVGG
>NZ_LS483441|899788:947853|925402_925957_+|WP_162183361.1|DBSCAN-SWA
MVSMLFEQLKIVFPAWKHAFPTDDAQRRALAEWTRALVDAECTSREQLQLGMRVAREQEIPFFPSTGMFIKWCQITPESLGLPTVDQALADVVRHRKSHPAVVIAARATRFERQTLTADEYRKVFAQAYDQVVRRVMAGEDIEAEVLKGLPTREQIRHSPEFYQQAGQRGVASLKALFKRGGGA
>NZ_LS483441|899788:947853|939746_940265_+|WP_042016752.1|DBSCAN-SWA
MVRVERTSPHGISLMHYFETCKLRAYPDPGSKNGEPWTIGWGHTGPEVKPGLEWSQQQADSAFVDDLRRFERDVLSLVKVPLTQGQFDALVSFAYNVGSDIDADTIPEGLGDSTLLRKLNTGDYDGAAREFRKWNKNDGKVMRGLTRRRVAEECLFRGMDAAAAIKNGVAAA
>NZ_LS483441|899788:947853|902771_902987_+|WP_042016712.1|DBSCAN-SWA
MITKRKITIEDWSHIRKAKVRHALFCVAYRRLQGDSFRTACRTTAKRLKLHEPTLRLLARRYIKTTGDNTK
>NZ_LS483441|899788:947853|928866_929085_+|WP_080768058.1|DBSCAN-SWA
MTFNLALLPDQERQRIELNKQAALLVWQCRRNLATREDVARAIINQPVDNQEYFRDRLNHYREVKGSHEQVY
>NZ_LS483441|899788:947853|915773_916031_-|WP_042016726.1|DBSCAN-SWA
MHIKLYQRNYRDDLKQAIQQEHAGNHQDAALSYKKAQHHATSANMLEKAKFAMARRIHCLKQAKDPQWRQVNTKFQQLYQTQEHR
>NZ_LS483441|899788:947853|947365_947539_+|WP_154676067.1|DBSCAN-SWA
MAKPDKAGSEPTVMLIKVIRPFKNYSPGDITGFDAAKAQALIDGGVAEAYTAAEGEE
>NZ_LS483441|899788:947853|909993_911349_-|WP_010673214.1|DBSCAN-SWA
MNQPHHATGQTASPAAGQGLLERLFALRGHGTTARTEVIAGITTFLTMVYIVFVNPQILSAAGMDTQAVFVTTCLIAGVGSILMGLLANLPIALAPAMGLNAFFAFVVVAGMGYSWQVGMGTIFWGALGLLILTLLRVRYWLIANIPLTLRVGITAGIGLLIALLGLHNAGIVVASPATMVTVGNLTSLPCLLGLLGFFLICIFSARGVHSAVLIAIVVTTTLGWLFGDVTFKGFVSVPPSIAPVFGQLDLMGSLDISLAGIIFSFMLVNLFDSSGTLIGVTNRAKLADDKGHFPRMKQALVVDSVSSVGGAFMGTSSVTAYIESSSGVAVGGRTGLTAIVVGILFLLAIFFSPVAAMVPAYAAAGALIYVGVLMCSELTRVKWEDLTEAVPAFMTAVMMPFSFSITEGIAVGFISYCVMKAGTGRWREINPCVLVVALLFVLKFVWVDAH
>NZ_LS483441|899788:947853|931365_931548_-|WP_145983732.1|DBSCAN-SWA
MANRELMKALEAVVSEYANGRGPLVKFEKQNEAIIKLVSENKSLFRYLGTEHTAWQDVAC
>NZ_LS483441|899788:947853|930377_930668_+|WP_042016858.1|DBSCAN-SWA
MNKTEEAYAAHLRTLMLAGEVLHYEFEPLKLRLADKTFYTPDFMVVRRDGLIELHEVKGFWEDDARVKIKVAAKQHWMFTFVGVQRKGAHWSLEAF
>NZ_LS483441|899788:947853|901998_902502_+|WP_042016710.1|DBSCAN-SWA
MNKITIADLSEELLDVINGQRALINELAERAGLTSAQVQTIQMDASQRHQRAKVAAAKAKANREAYEEDSRQMAAWVYATRFDFNNAKEWGKAAATEWLVICDRSGSEHGRDHTFKYHEPTQDELLEALKDLGRWSRATEEHNKDRREHAQRTLPKVKAKLAALLTA
>NZ_LS483441|899788:947853|938035_938542_-|WP_145983734.1|DBSCAN-SWA
MNEELEVRVQPFSGKIDADFSSGEPSLDDFYHKKFVKQWQKNVLAGHEVVSDSDGVIAFATMSATKIEKSKLGAFGKGLPYREVSFVLIGRFAVDKDYAGQGVGSFFIGHLVEIALASAEQVGSFGVFVDALPGAIGFYEKLGFVKCEAEDGSIGTTPMFLPFPKRKT
>NZ_LS483441|899788:947853|916256_916694_-|WP_042016728.1|DBSCAN-SWA
MSVVQDVAEWIHARTGGAISADVAAEFSLTVSEASIVMGQIHREARFTTRIEHFCMVGDNGRGRHTRRLFVDAVKPPQWRKTPVIGINGDQVVRFDSVTDAETKGGFVRVGITRCLAGQQKQHGGYRWQIDTTKGAGQCTVTPTP
>NZ_LS483441|899788:947853|915300_915774_-|WP_042016725.1|DBSCAN-SWA
MASRGINKVILIGNLGQDPEVRYMPGGNAVTSITLATSDTWRDKQTGEAKERTEWHRVVFMGMLAEVAGKHLKKGSQVYVEGKLRTRKWQDQSGQERYTTEVLVDSFTGVMQMLGGSGQNGGGKQQAAGSQQRPTPQPAQSPAYTEQPIAYDDDLPF
>NZ_LS483441|899788:947853|926216_926444_+|WP_042016854.1|DBSCAN-SWA
MHYYAQHTPTRDWQAPLLGIEELAKAQEGGICVSIGMWVIHDIGFGAWSTEIGVIVGAAMHKAALQATTGRGRKG
>NZ_LS483441|899788:947853|920281_920485_-|WP_042016732.1|DBSCAN-SWA
MHPREFIAKHIKATLEKEEFPPHAVSLGVKEATFYFDRTPSFAKGKVFDECLKAARAVARVAKKAKP
>NZ_LS483441|899788:947853|927430_928240_+|WP_042016741.1|DBSCAN-SWA
MQVLSFDSMEFGKVRLIDEAGRVLFCAVDVCKALGYSNPRDAVKRHVDEGDVVKRDTPTTSGMQEVSFLCESGVYALIFGSKLPAAKGFKQWVTGEVLPSIRKTGQYAIGQSPVINVEAVQVELLFVETAARMLNVSNSGKLGMLQTIQRQHGLPNLLPAYAIDAPSDATDGSSRPTFSATEGLKQHGVSMGVRYFNALLESNGLLTKMRRPSTKSPDKQKEFWAITPKGLLYGKNIVDPRCQRETQPHWYQSRFAELLAKVGLGKVAA
>NZ_LS483441|899788:947853|945005_945941_+|WP_042016761.1|DBSCAN-SWA
MPKLINYPHLASMAFGQPLYATQDVLAGVKSLLLPRMLGNHRDIMAADELPDGFEPAPLEAKGEFKNRIGGLAVIPVHGILMARRGHIDATCTELTSYEWVRMQIATALADERVKEIVLDINSGGGMAVGCKELAEYIYSKRSVKPITALVNFAAYSAAYFIAAACTRVVVSETGGCGSVGVIMEHMEVSKWEQEVGLTFTTFYRGERKKDGTPHEPLSEGAMAAIDHRMDQAYELFVSSVARYRSLSAEQVQATEAALFSGSEAVANGLADELANPQDYLNALAASVANQGKPQQSVGLRARAIELQNQL
>NZ_LS483441|899788:947853|916086_916281_-|WP_042016727.1|DBSCAN-SWA
MHRYTYTLNAATELGAAPDRLTGTIEAHHPMTHQQIRLAAIDKAPAQYLNFNELEYQEIECPLN
>NZ_LS483441|899788:947853|947541_947853_+|WP_042016765.1|head,tail|DBSCAN-SWA
MLLITVVEAKAQCRIEPEMTDEDALLTGLIEAAISHIQSDINKPLVAAGEEGQPLTPALKLAALLLIGHWYTNREAVVTGTIATTLPLAYDSLIHPYRDIVVG
>NZ_LS483441|899788:947853|940261_940804_+|WP_042016754.1|DBSCAN-SWA
MNPVRQFLNAYPVVWFFARLTAVALLAWWIHHSGYSSGAHDKGLEWSEKWNKQAAELATARADAVTAAREVEQRRQADIEKVRQDAEQEIARAESDAAAASAVAAGLHEQARRLAARANQCASHTGAAQPGETARQPAVVLADLLSRADARAGELARAYDRARASGLACERAYHSLISQQ
>NZ_LS483441|899788:947853|922334_923027_-|WP_080768057.1|DBSCAN-SWA
MDEKQTPMARFEADKIAFSQRLNAALDELGWPARGRIVRLKRTLRESLSEISVRKWLKGEGLPEVKRLGELSRITGKSVQWLLTGTDPGDGNIEPQPFPIYQVPLISWVSAGEFKDCGDIPSLEEAEEVTISPVRVSTRAYAVRVKGDSMVAPMGGKSYPDGTIIIVDPEVEPAHGKKVIARYGSDMTFKELVMDSGSWWLKPLNPQYPLLPVNEDVQICAVLVCSVMVE
>NZ_LS483441|899788:947853|929068_929332_+|WP_042016743.1|DBSCAN-SWA
MSKFTSRSAARVQHLQQQASNPVGAAINASAELFRSIDTACPGMTAAEAARRIIASESLSVRRTASYQLLARLGPLLDKLEMVEKLG
>NZ_LS483441|899788:947853|941861_943583_+|WP_042016759.1|terminase|DBSCAN-SWA
MAARKSYPYVNVANGYARDIVRGKIPACRYVIQACQRHLDDLAKEKSAKFRYRFDKDKAERAAKFVQLMPHTKGEWAFKRQTLNLEPWQLFIICCVFGWVRKGSGLRRFREVYNEIPRKNGKSALSAPVGLYCFAADNEFGAEVYSGATTEKQAWEVFRPARLMAKRTPALLDHYGIEVNASNMNIPADGARFEPLIGNPGDGQSPSCAIVDEYHEHDSDDLYTTMITGMGARKQPLMWIITTAGYNIDVPCYDKRREVIEMLAGTVPDDELFGIIYTIDEGDDWADPAVLAKANPNMGISVYSDHLLAQQAKAIKSARFANIFKTKHLNVWVSAKTAFYNMQRWAACEDKSLTLEQFAGDECILGFDLARKLDMNSMARLFWRDIDGKRHYYSVAPRFWVPEDTVFDNDNRRLAERYQKWVNLGELSTTDGAEIDYREIFEEAKEANLTNKVLETPLDPAGAIALSHSLADEGMTPITITQNYQNMSAGMKELEAAIQAGRFHHDGNSLMTWCIGNVIGKYLPGNDDMVRPIKESADQKIDGAVALIMTIARAMVPDRGDDRSIYETSDVLC
>NZ_LS483441|899788:947853|943576_943765_+|WP_033130572.1|DBSCAN-SWA
MLTQLFIFIVGLLGAAALAYGASLYAPPLGWIVGGLLCLIWSLMMSRAVAAAEFAKRHKGDS
>NZ_LS483441|899788:947853|899788_900874_+|WP_042016704.1|capsid|DBSCAN-SWA
MSAYGTFPTFQNVTHLGQNNGQGDTRALFMKLFAGEVLTMFRNQCVSLGTTRVMTLKGGKAFDFPVLGMSHNAKYHKPGELIRAGGIKNVLRTVTVDDVAVAAVFVAEQDEDLSSFEVRSHYARELAYELSNMIDKNVFRTIANAAFITNKELAIARFGENGVLEDETFTDNITLRATDAAGRPMTRGQQIVDAIFRARTEFRKASVPGIPVCVLKPDDYEALTNAAGDLGNMAWLDKRFLGQTGEDKSNGNADTGLRIAGMKIFESNNLPDQDESNGLIGSPEPLSVEEGGSGRTAAYRGNFSKLLGLVYTKDCAATVKVRDIATKWVPEPLRVGNTVLAKMFVGHNILRPACAVALLEA
>NZ_LS483441|899788:947853|916690_918502_-|WP_042016730.1|DBSCAN-SWA
MSKSLRRSRAVRAKVTGAPLNLDSAINVDLFAGGGGASTGIERGLGRPVHIAINHNSKALSMHQANHPEALHLQEDIWAVDPVAVLAGRSVGWLHASPDCTHHSQAAGGQPRKQEIRSLAWVITKWLALSKPAVLSMENVKQMRTWGPLIAKRDKATGRVIKLVEVQRGKKTKIEQHIAEPGERVPRQQQYLVPDPKRAGQTWRRFLASIERMGYELDHTVKNAADYGAATSRQRLYLVARRDGEPVCWPAPTHCKAPAPGSHLKPYRVTADHIDWSIPCPSIFLTKEEARAQGLNVKRPLADATLERVAIGVIREVLTNPKPFVIELANWSGRGVDSVDAPLRTITGWPKGGAFAVCNPSLAPLVVRHFGKGGEHGVDEPAAAIMAGGGGKSMLAAPLMVQANGGFNTVPARSVTDPCSTITSSGSQQQLASAFMVHLRKNLPPSTPESQLPTIVSAGQHHALVQTVMASPGECGLTPEQEAGALRVSAFLMRYYSSGGQWGAVTEPMHTITTKDRLALVTVTWCGNTWVIVDIGLRMLVPKELYGCQGMPRHYIHDRGHDGTPLSITDQVLMVGNSVSPPPMAAIARANNPYKQLQARRAA
>NZ_LS483441|899788:947853|911604_911934_-|WP_042016723.1|DBSCAN-SWA
MTQASTTRLTIQIRLEPGCLGPDGKQHIDTFCAAANRILAAIEPQRVHWVLLPRHDKQLAEQAYFLDGRPLSETQATLLLQRMGLALAPLLEQSDAVLSQLIERYQKNR
>NZ_LS483441|899788:947853|923372_923882_+|WP_042016735.1|DBSCAN-SWA
MTEQRNDTTAKVSAVFRSSDVMAAAYGIGHRFNASELARLMGRKPAEFCKKLNPDCDDRHLTLAEAVAVTEITGDNAILDAWAVSRGKVLVDLPAGVVSDDDLVEQVLLAQAVFGKLMQAIHDARADGVIDRIEQGQIERIGTQAAEHVLGLISSTGANVRQLPTTSSK
>NZ_LS483441|899788:947853|902983_903454_+|WP_042016714.1|DBSCAN-SWA
MTQPYTYTLATDGACNTNHTKASVRVAGWGFLAVRSDGRKVERCGYCVGAGESNQTGELEAVIQGLSLLKPGSVVEVLTDSAYVINGATQWLAGWKAKGWKRADNKPVQNRDRWEQLDDLLNTRQVTFKKVKGHSGHPMNERADQLAVTGMNRAGM
>NZ_LS483441|899788:947853|943764_945018_+|WP_042016760.1|portal|DBSCAN-SWA
MFLPMMFGSGRKGGNFSQWISSMAGKTTKAGVLVTPETALAQGVVRACVTLLAESVAQLPCELYRRDDDQRLRATDHPLYDLIHNQPNQKDTAFEFNEQRMGHLGLRGNSYSLIDRDGRGFITELIPINPDKVAVLKGPDGLPYYQLLDGSNQILPMRMVHHVKAFSLDGYLGLSPIQTNPDTIGLAMAVDEHAGRVFANGTTLSGVIESPKDGAKFDTQAKVDAFLGKFVERHSGLRNAFSVALLQEGMQYKQLAMNNEQAQLLESRKYGANEICRLYKVPPHMIGELERATNNNIEHQGLQFVIYTLLAWVKRIEGAMMRDLLLPAERKNLYIEFNVSGLLRADQKSRYEAYALGRQWGWMSVNDIRRLENLPPVAGGDIYLTPLNMVSTGSLPPGITKASAEQLNDIEAILCRS
>NZ_LS483441|899788:947853|908395_909064_+|WP_042016721.1|DBSCAN-SWA
MKAMILAAGRGERMRPLTDLLPKPLLAAGGKPLIVHHIEKLKAAGVTTLVINHAWLGHKLVAALGDGSALGVSIHWSAEESALETAGGIVQALPLLGCEPFLVINGDTWLDLDYRALVNQPLGEDLAHLWLVPNPPQHPQGDFSLQAGRVLDTPALTFSGVGLYQPAAFAGLPCGARKLAPLLRDWMAQGRVGGSLLAGEWRDIGTVDRLRELDEQLLAGTH
>NZ_LS483441|899788:947853|909083_909908_+|WP_042016722.1|DBSCAN-SWA
MRIWGKVLGTFFGFLLGNIFGALLGLWIGHRFDRGMGIRGAFQRAPSQQQQAVFFHATFAVMGHIAKASGQVTEHEIRVASNLMDRMRLAGEQRVRAQESFRQGKESDFPLRETLAEFRQASLGQRDILRFFLEVQLQAAFADGQVEANERAILQTIADELGFSRIELARILAMAEAQMNFFHRQQQQGSGQGQQYRQEPPSRDRLKDAYQLLGVSESDSDQEIKRAYRKEMSKHHPDKLAAKGLPPEMMEMAKEKTQEIQQAWEWIREARGIR
>NZ_LS483441|899788:947853|913741_915049_-|WP_052455418.1|integrase|DBSCAN-SWA
MADRNQELIDIVAETPGVELHGKSLRIDFRFHGKRCRETLNMPATKANIKHASRKREAILHEIAIGVFDYAKHFPDSKNAHRFAGTTASRDISLGDLVEHYLKIKDVDIGDNARGRYRSILGMLASDLDHTRVVSTFRTEDLQQWRRYLMTEPRNRTSKPLAPRSVNYYMMVAAGLFNFAKQNGYTHQDLSSVLTKVEVIRDKPDPFDQDEFRRLQESARHDMDAMWVQLACWTGMRTGELCSLAWEDVDLERGELQIRRNITQARNFKVPKTGHERTIVLLPPAIEALRRMRPMTAMRQSHYIKKTLRDRRQVDEKVTFVFSPDVTSKTPGLSICYTAFTLGDKWDRLIKRAGIRRRTQYHMRHTFACWMLTAGANPEWVASYLGHEDSTMVRTVYGKWIPEQDRDEADRVWGRLGANFSDLAPIQPQDFKATQ
>NZ_LS483441|899788:947853|935286_936561_-|WP_042016748.1|DBSCAN-SWA
MPTAIALVDVNNFYASCERLFRPDLKGVPIVVLSNNDGCVVARSAEAKRLGVKMGVPYFQIRELYEEQGGIWFSSNYALYGDMSNRVMTTLESMAPTVEVYSIDEAFVELSESWAGDLLAYGRQIRERVQQWTGLTVGVGIAPTKTLAKLANYAAKKWPATGGVVDLRDEGRRAKLMAITPVEEVWGIGRKLTAKLNKQGINTVADLVAADPKSLRRQYGVVVERTVQELRGIPCAELEPMAQAKQQIICSRSFGERITAFGPMLEALAGYMERAAEKLRAEGMCCQHVTLFIRSSPFSERETYYSNQVSTRLQTPTSDTRDLLALVEPLLRRIWRDDVRYMKGGVMLADFTPASMHQGDLFADQQQDPRSEALMKVIDQINQGRLGKVYFAARGRDASEWMMKRDQLSPRYTTCINELPRVKV
>NZ_LS483441|899788:947853|938492_938852_-|WP_052455425.1|DBSCAN-SWA
MKNAANAVASSAMKRPKQERFEFRVTDEIKELFEQAASISGVSVSAFVKMAGRKVAEEIIESERTLRLTTQSYAKMIELLTNPPEFNTRMTAAIESSRSGVLKIERRTRSKSTAVFRQD
>NZ_LS483441|899788:947853|934360_935257_+|WP_052455424.1|DBSCAN-SWA
MPDLIPELIVMASDPTVKTPDLLRRALVAARRLKLHEWVKWIGYELRGYPNEQELPPYREVSVPLMGQDNLGQLWPITNPALWNLGKYQSVAIKQPIGEIEAWAIGGMDIKLRFPDRVEQQLLDCIGHAALPVRVLTIGSISSILDMVRNEVLEWSLALEAEGILGEEMSFTTQEQDQAKQLAPVTIHIEGGIHGGQLMVSSPGSQQQQTVTSEQKVEALEALLPWLQQVIEQGQLQKDACGELQAELATLQAQAASPKPKWPVIGAVAGSVRAILEGASGGVLAAEALGWLATLATS
>NZ_LS483441|899788:947853|912045_913713_-|WP_039040030.1|DBSCAN-SWA
MAQFIYTMNRVGKVVPPKRHILKNISLSFFPGAKIGVLGLNGAGKSTLLRIMAGIDTEIEGEARPQPGIKIGYLPQEPKLDPEQTVREAVEEAVGDVKRAMARLDEVYAAYADPDADFDKLAREQGELEAIIAAQGGHNMENQLERAADALRLPAWDAQIKHLSGGERRRVALCRLLLEKPDMLLLDEPTNHLDAESVAWLERFLHDYEGTVVAITHDRYFLDNVAGWILELDRGEGIPWEGNYSSWLEQKDARLAQEASSEAARRKSIEKELEWVRQNPKGRQAKSKARMARFEELNTNDYQKRNETNELFIPPGPRLGDKVVEVANLCKSYGDRQLIDDLSFSIPKGAIVGIIGPNGAGKSTLFRMMSGQEQPDSGSITLGDTVVLASVDQFRDQMNDKKTVFEEVADGQDILRIGNYEFPSRAYIGRFNFKGSDQQKRVGELSGGERGRLHLAKLLQTGGNVLLLDEPTNDLDIETLRALENALLEFPGCAMVISHDRWFLDRIATHILDYQDEGKIEFFEGNFTEYEEWKKKTYGAEAIQPRRAKYKRIAK
>NZ_LS483441|899788:947853|937142_937772_+|WP_042016750.1|DBSCAN-SWA
MCINYIPTTKAVLVEYFGVDDPGFGWKEEVWQDYLAPILIQRDGRRQALIASYGMVPKRKVQPGNKHYTTMNARAETVGEKPTYRHAWQQGHLCLVPMSGFFEPCYESGKAERWRISMADGRPFAVAGIWRAWQEEQGYTFSFSQLTINADTHPLLRRMHKPGDEKRSLVIVSPDDYDTWLGCKDPELARTYLVQQDICQLKGISMPIP
>NZ_LS483441|899788:947853|929328_930318_+|WP_042016744.1|DBSCAN-SWA
MMPTHPVFVPEMGMVLLKVGEGLAQLRTSLANRPAVLVPAPDGGDLLTQFPELAIALLNPSIVNAAGGELALRSVGQCLIGHGCIGESVTTEMGGLPLPLCWHHDNAYRDGQLPFNQGEYAAAIARALLTRVAGWCGVALAQLQARDLCWWASVFKVQQHLPIAVVRHACRLPPLEPERLLVPGRGYRETDARYRVNRIELLEQDPLAELRGRLRIKPAVKAIDPEPPMLHIPRPKMRRWESANYLAFVRQLPCVVTGQTDGIEAHHVVGHGLSVMGSKAHDLMTFPLCHQAHMELHNKGWQQWEQAHGSQLDHVVMTLNKAAGLGVFG
>NZ_LS483441|899788:947853|936563_936980_-|WP_042016749.1|DBSCAN-SWA
MLPHATNAPIIEIPLFLTPAACGFPSPAQDYVEQSIDLNQHCVPHPAATFYVRASGHSMVGEGINDGDMLIIDRAITARHGDIVLACLDGEFTVKILQSDPPALLPSNPDFAPIILQEGQELDIFGVVTFVLHKTRRG
>NZ_LS483441|899788:947853|926937_927327_+|WP_052455422.1|DBSCAN-SWA
MTVKPKELNERGLIDLAGVKVYVAGPMTGLPQFNRPAFFAAEAYLQGQGARVMNPAVLPDGWDHDAYMRIAIPMLMECEAVAFLPGWQQSKGARQEFTRAHAFGLVLLQLDVEEIPLGLLVRQHLPLMV
>NZ_LS483441|899788:947853|941366_941852_+|WP_042016758.1|terminase|DBSCAN-SWA
MAGAAAVPGRGRKPKPTALKRLGGNAGKRALNKDEPIFTPLIGVACPEWLAEDPWAPTLWDMVIKELCAAEVLCITDLHNLEAFCAAYSRWRRAEIEITKHGLVVEGATGGPVKNPACTVANESLKQMTTYGAMLGLDPSSRSRLIGGNKKKGGGNPFAAL
>NZ_LS483441|899788:947853|939436_939760_+|WP_042016870.1|holin|DBSCAN-SWA
MPDKDLGLLAWLLAWADSHWPALYGFILSVVISWLRVTYSGGGVRQRLLESLLCGAISLSVMSGMELFGIAATASGFVGGSIGFLGVEKIREFAGRVLDRRFGNGPS
>NZ_LS483441|899788:947853|907388_908399_+|WP_042016720.1|DBSCAN-SWA
MHDRASLLLQWARRISGDANLSLTLISGDASFRRYFRGGGLVWVDANPKTEKNHEFVRNAAALHDAGLLAPEVKGVDYEQGLLAVTDLGDTQLIGCLNEESVLAWYGKAIALLPRLGAVALELEPFDEAFMARENAIFPEWLLGHHLQLALSDEEQQLLAETFACLTASNLAQPQGVMHRDFHSRNLMVCGGTNPKESDLALIDFQDMVIGPLSYDLVSLLKDCYVRWPDAVIEQGMRLGFDTLQGAGLLGNLDYAAFRRAADLTGMQRHLKAAGIFTRLYHRDGKAGYLKDIPRTLGYVVDVCRSHGAAYPVLARFGQWLEQVVLPGLARTGVTP
>NZ_LS483441|899788:947853|905038_905485_-|WP_042016717.1|DBSCAN-SWA
MFDNLKFKAVTTTGKSTSEPVSITHSFKTKKNELLFRISSEVMGQCNFQYQDKVQILFASDNTVCRIQKSDKPGCVTLSQQSKKSEASPAIIRLSFRPGLPDFLTQESKVARKQFCRVKYLHKDDLIEFKDGCLTFQLDLVDSEEEEL
>NZ_LS483441|899788:947853|932884_933784_+|WP_052455423.1|DBSCAN-SWA
MSALIPELIAMASDPAVATSDLLRRAFVAAHRLNLPEWIDWITHELQGYPEGVPLPPYRQLQGEIVADHPMRGLTQVSFSSAQSASEWGFCNLDTPVEEIEGWINEGDDVVMTFPPGAEDALRKAIRPSCRPLRRFHLSMFKALIGAVRNKVLDWALKLEGQGILGEGLSFTAREQAQAQQLTPVTHIHIGRDFTGGQLMVSSPGAQQQQTITDEQKKAALAALLPWLQQVIAHGQLQQEVCAELQAELDTLKAQAASPKPKWPVISAVASSVREILVGAGGEVLAANALGLLATLSAG
>NZ_LS483441|899788:947853|903725_904451_+|WP_042016716.1|DBSCAN-SWA
MKQVESISLHFMGNTVTVNQKDGLFCLNDLHRAYTGGMSRKQKPHDWCKGILNGEKSRHYNLTTFKGKHGGTYANEQGVYAYASWLDDDFHNAVLQTFSSAARGDAEGAVKIAQSSVTLTWRETLREGNKAFCHAIYTAQKEGNVKGNLNHVMANIQSLVCKAVTGLDGTAFKKRYGMSARDFLVSQDDGKRLGVMARIEGKVEALLEAGMDYMMIKTALAKDVMKAIESWKYDDLTVSNG
>NZ_LS483441|899788:947853|926642_926948_+|WP_042016739.1|DBSCAN-SWA
MAKAFFVLMYLFVALFVLAMVPYEGGMGWQMLQAPVVWVILAGWVLVMFPCPVVRLLLAPLRAILLLLVWLGTLLLAITKVVLVALNRVNRDLAGEAHHDS
>NZ_LS483441|899788:947853|923134_923353_+|WP_042016734.1|DBSCAN-SWA
MHTLLTRFGTKSAIAAALGITPEGVSNAFRRGKVPSTWVAKLKQQGLSQSELAELPLTDEGRAIVSAFTGHL
>NZ_LS483441|899788:947853|931684_932248_-|WP_145983733.1|DBSCAN-SWA
MNPSNIRNADFIDIQRSVFGFTGTILGGQLELPKQLAIGVGDEQAMKDIAAFRGAGHFTFNPVDIMPIEMTSGLGMPVRLVVYYDRAPVAYAVGYMTNVSIDLTFWEVSRMAPDEIVVYWLPILTASLDDLSLGMERITQNEIQVQQFAFTSPAPCDIIAFKAVGFNHVDNYTKGIPAVVTYRNNGL
>NZ_LS483441|899788:947853|902559_902772_+|WP_042016711.1|DBSCAN-SWA
MTANETFLVHPSDFVKRLQAFATLSLGRRPSTGQVQNAINRYVMQSHGTDQESMLALVRELFPTAEQEAA
>NZ_LS483441|899788:947853|946009_947299_+|WP_042016764.1|capsid|DBSCAN-SWA
MKTIETLRRERGEIVAQITVLADIEKQGGTLSAEQLAEFTSLESKVAEISAQITRLETAERLAAQQAVPVTASASMIGSPAVHVKQELKQYPGAGMARIAMAIAAGEGDMELAEQFAANEIGDAGIAMAISTAAGSGGALIPENLHSEVIELLRPRTIVRKLGARPVPLPNGNLSMPRMSGGATSSYVGEGVDAKATGGSFDDVKLAAKTMITLVPISNQLIGRAGYNVEQLVLGDMLAAMGGREDKAFLRDDGSNNTPIGFKKVATDAGRTVAWTGTADLDTIDAYLDLLILKLMSSDSMMINPGWGMSPRSWMKLFGLRDGNGNKVYPEMAQGLLKGYPVAHTNTIPVNLGAGTNQTEIYFADWNDVVIGEQDNMTIDFSREATYVDAAGELVSSFARNQSLIRLVGNHDVGFRHVEGLVLGTAVTW
>NZ_LS483441|899788:947853|928271_928895_+|WP_042016742.1|DBSCAN-SWA
MNNPKKVAVVDIETLGQGVDAVIGTIGVVIVDVGQLRAVDEFYCRVDLAQGRQRDDDTLAFWERQKVDSPAAWEEMFGNAGRLFLVDALQALANFLGRHFEKVAAVELMGNGSEFDNVLLTHAYQQWGVEQPWWFRGNQSLRTVVWMGRQLLGIDPKYQLSFEGTRHHALHDARHEAAYLIHILNAFKQGLAGVVSAGHDIQSGAAT
>NZ_LS483441|899788:947853|926440_926650_+|WP_042016738.1|DBSCAN-SWA
MNIGMLFGMLIVGWALLLAVLLVLIWVALRAWREEVQEDEAALLDEPRLVSACRELSELAAKTKEASHG
>NZ_LS483441|899788:947853|924221_925295_+|WP_052455420.1|DBSCAN-SWA
MGEVIRLAAPVAASTQRGCNVDDNARTGFRLFYRSMKNAAWYRDVAKKAVMFHLILEVAHEQRTVVFGGKRVQLSRGQLVCSAKSLGQECGISEDQARRALEFFKAEGAISCVGARGKGGYTVVSLLNFDAYQRGLSQIFSAEYGADSEAAPALGLEAGSQSGGADLPAEQHAEDYISKNIKTDLKDSSSQLAVATFDQQSEQPIADEPVTADPLPDEPTVAEPKTRVIPGAAIQTPNGKAWGTAEDLTTAQWMFKRVQVIAPTALEPNWAQWANVIRLMRELDQRSHRDICELYDWVSRDAFWCTNVLSPQKLRQQWTPLTVRRNAPTHRPVSGQHTDLTQSMTADELNRRMQEGF
>NZ_LS483441|899788:947853|901303_901888_+|WP_042016708.1|DBSCAN-SWA
MDYQTADYGFSVETCDLPSYSSGVNDQGEALYELDGIEMTKAQAEDFKDYFFDDEDDHALSQDNDTESLPDAILSGLNAVNDALGGGGVAEFYADELLGLGESRMDSVVSSSGMSREEIQSHATAVMIDMAAQVGMPSDYLMNELQNDINRVRSFNSQSGLKLLREAIADGIAGEYDSAMTKWDRLRRALQSVK
>NZ_LS483441|899788:947853|905873_907175_-|WP_042016718.1|integrase|DBSCAN-SWA
MMKHLQLRRRRYYLHWNVPAELRDHPFFGGRAIYTKTLETSDLQQARRMRDAIVAEFNELLERVRAAPRRHRFNHLLAEIRAAVEESNRYSSPNDDDEHLFHAYDVEAAVASGDLVKADAIRVALHGDSSLAQDYAMTLLEAVDGFANEHSHSVNKAVISKARQGAKSLLSILKVKDIDLSQIEPRDVTRWLQAISTEKSDWTRKGYRSALSSCWEWCYLHKEVDGTNPFIAARFKSGIAPQKYKPFTFEQLKVMAETASLPLHQLIKFGLVTGCRIGELVSLTPEDFEVKGNITLIRIKDGKTANAVRGIPLPRYLWEELKGHVCSGLWLDRHGKTSPSGWSSKFSVFKGKITGEREKRQCFHSFRGMAITAYQNAGIQEGMTSQIVGHSKQGLTLSYGLYSSGYNYAHQLEAVEKMLAEENMSQFLKLFDK
>NZ_LS483441|899788:947853|901079_901304_+|WP_042016706.1|DBSCAN-SWA
MSTQTQHPNLQRKKPQARTTAILWEDVIPKADALTLHFSKQAGFALTRTQMLNALVNREFDKLRSQGELAGEVQ

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_042016704.1|899788_900874_+|capsid	phage capsid protein	A0A1B1IWN1	uncultured_Mediterranean_phage	4.5e-28	26.0
WP_042016706.1|901079_901304_+	hypothetical protein	NA	NA	NA	NA
WP_042016708.1|901303_901888_+	hypothetical protein	NA	NA	NA	NA
WP_042016710.1|901998_902502_+	hypothetical protein	NA	NA	NA	NA
WP_042016711.1|902559_902772_+	hypothetical protein	NA	NA	NA	NA
WP_042016712.1|902771_902987_+	hypothetical protein	NA	NA	NA	NA
WP_042016714.1|902983_903454_+	ribonuclease HI	M4QQT8	Vibrio_phage	4.6e-14	46.3
WP_042016716.1|903725_904451_+	KilA-N domain-containing protein	NA	NA	NA	NA
WP_042016717.1|905038_905485_-	hypothetical protein	NA	NA	NA	NA
WP_042016718.1|905873_907175_-|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_042016720.1|907388_908399_+	phosphotransferase	NA	NA	NA	NA
WP_042016721.1|908395_909064_+	nucleotidyltransferase family protein	NA	NA	NA	NA
WP_042016722.1|909083_909908_+	co-chaperone DjlA	NA	NA	NA	NA
WP_010673214.1|909993_911349_-	NCS2 family permease	A0A0R6PHV4	Moraxella_phage	1.0e-66	37.8
WP_042016723.1|911604_911934_-	hypothetical protein	NA	NA	NA	NA
WP_039040030.1|912045_913713_-	energy-dependent translational throttle protein EttA	A0A2K9L3Z8	Tupanvirus	6.6e-39	27.5
913148:913163	attL	NA	NA	NA	NA
WP_052455418.1|913741_915049_-|integrase	site-specific integrase	Q8W658	Enterobacteria_phage	1.3e-79	40.4
WP_033130544.1|915024_915234_-	DUF1233 family excisionase	NA	NA	NA	NA
WP_042016725.1|915300_915774_-	single-stranded DNA-binding protein	R9TR60	Vibrio_phage	9.3e-47	75.0
WP_042016726.1|915773_916031_-	hypothetical protein	NA	NA	NA	NA
WP_042016727.1|916086_916281_-	hypothetical protein	NA	NA	NA	NA
WP_042016728.1|916256_916694_-	hypothetical protein	NA	NA	NA	NA
WP_042016730.1|916690_918502_-	hypothetical protein	Q5QF27	Pseudomonas_virus	3.9e-154	45.0
WP_042016732.1|920281_920485_-	hypothetical protein	NA	NA	NA	NA
919523:919538	attR	NA	NA	NA	NA
WP_080768057.1|922334_923027_-	hypothetical protein	B1B6L9	Salmonella_phage	8.5e-25	39.2
WP_042016734.1|923134_923353_+	hypothetical protein	NA	NA	NA	NA
WP_042016735.1|923372_923882_+	Lambda phage phage regulatory protein CII	NA	NA	NA	NA
WP_052455420.1|924221_925295_+	hypothetical protein	A0A1I9KG10	Aeromonas_phage	6.3e-35	42.8
WP_162183361.1|925402_925957_+	replication protein P	A0A1I9KFB0	Aeromonas_phage	2.3e-65	68.1
WP_042016737.1|925956_926217_+	hypothetical protein	A0A1I9KFB1	Aeromonas_phage	1.9e-14	53.8
WP_042016854.1|926216_926444_+	hypothetical protein	NA	NA	NA	NA
WP_042016738.1|926440_926650_+	hypothetical protein	NA	NA	NA	NA
WP_042016739.1|926642_926948_+	hypothetical protein	NA	NA	NA	NA
WP_052455422.1|926937_927327_+	DUF4406 domain-containing protein	A0A1V0E824	Vibrio_phage	1.8e-19	52.3
WP_042016741.1|927430_928240_+	hypothetical protein	U5P4K5	Shigella_phage	2.1e-30	36.6
WP_042016742.1|928271_928895_+	3'-5' exoribonuclease	A0A1I9KF44	Aeromonas_phage	5.9e-41	48.9
WP_080768058.1|928866_929085_+	DUF3283 family protein	NA	NA	NA	NA
WP_042016743.1|929068_929332_+	hypothetical protein	NA	NA	NA	NA
WP_042016744.1|929328_930318_+	DUF968 domain-containing protein	R9TRM9	Vibrio_phage	3.2e-33	31.4
WP_042016858.1|930377_930668_+	phage related protein gp8	A0A0F6R8N5	Escherichia_coli_O157_typing_phage	2.0e-23	58.0
WP_111736012.1|930667_931315_+	antitermination protein	NA	NA	NA	NA
WP_145983732.1|931365_931548_-	hypothetical protein	NA	NA	NA	NA
WP_145983733.1|931684_932248_-	hypothetical protein	NA	NA	NA	NA
WP_052455423.1|932884_933784_+	hypothetical protein	NA	NA	NA	NA
WP_052455424.1|934360_935257_+	hypothetical protein	NA	NA	NA	NA
WP_042016748.1|935286_936561_-	translesion error-prone DNA polymerase V subunit UmuC	F1C5A5	Cronobacter_phage	2.7e-125	54.9
WP_042016749.1|936563_936980_-	translesion error-prone DNA polymerase V autoproteolytic subunit	A0A1W6JNS2	Morganella_phage	4.3e-32	50.8
WP_042016750.1|937142_937772_+	DUF159 family protein	C7BGE4	Burkholderia_phage	1.4e-45	49.1
WP_145983734.1|938035_938542_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_052455425.1|938492_938852_-	DUF1778 domain-containing protein	NA	NA	NA	NA
WP_042016870.1|939436_939760_+|holin	phage holin, lambda family	A5X9I3	Aeromonas_virus	1.0e-20	52.5
WP_042016752.1|939746_940265_+	lysozyme	V5YSX1	Pseudomonas_phage	3.8e-70	76.6
WP_042016754.1|940261_940804_+	DUF2514 domain-containing protein	A0A059VF51	Pseudomonas_phage	6.7e-09	61.1
WP_042016756.1|940890_941271_+	HNH endonuclease	A0A1V0E8A5	Vibrio_phage	6.1e-33	58.1
WP_042016758.1|941366_941852_+|terminase	phage terminase small subunit P27 family	A0A2D1GNP3	Pseudomonas_phage	1.5e-47	59.6
WP_042016759.1|941861_943583_+|terminase	terminase large subunit	U5P0Q5	Shigella_phage	1.5e-259	73.8
WP_033130572.1|943576_943765_+	hypothetical protein	NA	NA	NA	NA
WP_042016760.1|943764_945018_+|portal	phage portal protein	Q6UAX8	Klebsiella_phage	6.3e-159	64.5
WP_042016761.1|945005_945941_+	S49 family peptidase	Q6UAX7	Klebsiella_phage	3.3e-80	51.1
WP_042016764.1|946009_947299_+|capsid	phage major capsid protein	Q6UAX6	Klebsiella_phage	6.5e-143	62.7
WP_154676067.1|947365_947539_+	hypothetical protein	NA	NA	NA	NA
WP_042016765.1|947541_947853_+|head,tail	phage gp6-like head-tail connector protein	A0A2H4J8C5	uncultured_Caudovirales_phage	4.1e-11	40.4

Sequences of DBSCAN-SWA_3

Nucleotide sequences of DBSCAN-SWA_3

>NZ_LS483441|1924919:1932575|DBSCAN-SWA
GATGAAACTGCCTATTTACCTTGATTATTCGGCAACCTGTCCGGTGGACCCGCGTGTCGCAGAAAAAATGATGCAGTGCCTCACCATGGACGGCCTGTTCGGCAACCCAGCCTCCCGTTCCCACCGTTTCGGCTGGCAGGCCGAAGAGGCGGTGGATCTGGCCCGTAATCAAGTGGCAGAGCTGATCGGCGCGGACCCGCGCGAGATCGTCTTTACCTCCGGTGCGACCGAGTCAAACAACCTGGCCATCAAGGGCATCGCCCATTTCTACGCCGGCAAGGGCAAGCACATTGTCACCTCCAAGACCGAGCACAAAGCCGTGCTGGATACCTGCCGCCAACTGGAGCGGGAAGGCTATGAGGTGACCTACCTCGAGCCCATGCCCAACGGCCTGTTCACCCTTGAGCAGATCGAAGGCGCCCTGCGTGATGACACCATCCTGGTCAGCATCATGCACGCCAACAACGAGATCGGGGTGGTGCAAGACATCGCTGCCATCGGCGAGCTGTGCCGTTCTCGCAAGATCCTGCTGCACGTGGACGCCGTCCAGAGCGTGGGCAAGATCCCGGTCGACGTGGAAGCGCTCAAGGTTGATCTGCTCTCCATGTCCGCCCACAAGGTATACGGCCCGAAAGGGATTGGCGCCTTGTATGTGCGCCGCAAGCCCCGTGTTCGTCTGGAAGCCCAGATGCACGGCGGTGGCCACGAGCGCGGCATGCGCTCCGGTACCCTGGCAACCCACCAGATCGTCGGCATGGGGGAAGCCTTCCGCATCGCCAAGGAAGAGATGGCGAGCGAGAGCCAGCACATCATGGCCCTGCGCCAGCGTCTGTGGAATGGCATCAAGAACATCGAAGAAGTCTATATCAACGGGGATCTGGACCAGCGTGTACCGGGTAACCTGAACGTCAGCTTCGCCTATGTGGAAGGGGAATCCCTCATCATGGCACTGAAGGATCTGGCGGTCTCTTCCGGTTCTGCCTGTACCTCGGCCAGCCTGGAACCTTCCTACGTGCTGCGCGCCCTGGGTCTGAACGACGAGCTGGCACACAGCTCCATCCGTTTCAGCATCGGTCGCTTCACCACCGAAGAAGAGATCGACTACGCAATCAAGCTCATCTGCGACTCCATCGGTCGTCTGCGCGAGATGTCCCCCCTGTGGGAGATGTTCAAGGATGGCGTCGATCTGAACACGGTCGAATGGGCACATCACTGATCCTTGCCAGCATGGCAAGGATCTGGTGAACAACGGAATTAGCAGGAGTTAGATATGGCTTACAGTGAAAAAGTAATCGACCACTACGAGAATCCCCGCAACGTCGGTGGTTTTGACAAGAACGATCCCAGCGTCGCCACCGGCATGGTCGGTGCACCGGCCTGTGGTGATGTCATGAAGTTGCAACTGAAGATCAGCGACGATGGCATCATCGAAGATGCCAAGTTCAAGACCTACGGCTGTGGTTCCGCCATCGCCTCCAGCTCCCTGGTGACCGAGTGGGTCAAGGGCAAGACCCTGGACGAAGCGGCCGGTATCAAGAACACAGACATCGCCGAAGAGCTGGCGCTGCCGCCGGTGAAGATCCACTGCTCCATTCTGGCGGAGGATGCCATCAAGGCCGCCATCGCCGATTACAAGCAGAAGAAAGGTCTTTAAGGTCCGGAGAGCAGTATGGCCATAACCATGACAGATGCCGCAGCGGCGCGGGTTTCCTCCTTCATGATCAACCGGGGCAAGGGCATCGGCCTGCGCCTCGGCGTCAAGACGACCGGCTGTTCTGGCCTTGCCTATGTGCTCGAGTTCGTGGATGAGCTGGCTGCCGAGGATCAGGTATTCGAGCAAAAAGGCGTCAAGATCATCGTGGATGCCAAGAGCCTGATCCACCTGGATGGCACCGAGCTGGACTTCGTGAAGGAAGGCCTCAACGAGGGCTTCCAGTTCAACAACCCGAATGCCAAGGGCGAATGCGGTTGTGGCGAAAGCTTCAGCGTGTAAGTGGTTCGATTGACCGATCGCCCATGTTTGCAACGCCTCGCAGTCCCAAGGGTGAGCCCTGTTGCGGCGAGTCTCTTGTGATCAACACCTTGCTCATCAACACAGTGGTGTGGACGCCAGTCCATGCCACTGCTTTCAAGTTCAAGACGAGTGTGGTTGCACTCCCAGCGCTATTGTCTGAGGACGAAGGATGAATCATTTCGAGCTGTTCGGGTTGGCTGAGGGCTTCGAGCTCGATACTCGCCAACTGGCTGACACCTATCGTCAGCTGCAGACCCAGTTCCATCCCGATCGTTTTGCGACTGCCCCCGAGCGGGAGCAGCTTGCTGCCGTGCAGCGTGCTGCCCAGATCAACGATGCGTTTACCACCCTCAAGGCCCCCTTGCGCCGAGCCGAGTATCTGCTCTCCTTGCGGGGCACCGATATTCGCGGCGAGCAGCAGACACTGCAAGATCCTGCCTTTCTGATGCAACAGCTGGAGTGGCGAGAGCGGCTGGCTGATCTCAAGGGCGACGCCGACCCTGAGGGGGCCATCAAGGATTTTCGCCAGGAGATCAGGCATGATCACCTGGTGTTGATGCAACGGCTGACCGACTCTCTCACCAGGGGTGAGGATCTGCAGGCGGCGGATTGCGTTCGCAAGCTCAAATTTGTCGACAAGCTCCTCGAGGAGCTGGAACGATTCGAAGACTCGCTGTTCGAGTCTTGACCCTCTAACGCAGGAATTGTGATTACCCATGGCATTACTGCAAATTGCCGAGCCAGGCCAGAGCGCCGCGCCTCACCAGCATAAACGTGCCGTCGGCATCGATCTTGGCACCACCAACTCCCTGGTCGCCGCCGTGCGCAGCGGCCAGGCCGACACCCTCTGTGACGAGCAGGGGCGTGATCTGCTGCCTTCCGTGGTCCATTACCAGGCCGATACCATCCGGGTTGGCTTCGATGCCAAGCGTGAGGCGGCCCTCGATCCCCACAACACCATCGTCTCGGTCAAGCGGATGATGGGCAAGGGGCTGGCCGACATCGATACCCGCCAGCAGCCTTACGAGTTCGTGGCTACCGAGACGGGCATGCCCCAGTTGCGGACCCGCCAGGGGCTGGTCAATCCGGTGCAGGTCTCGGCCGAGATCCTGAAAAAACTGGCCGAGCGCGGTGCCGCGTCCCTCGGGGGAGACCTCGACGGCGTGGTCATCACGGTGCCCGCCTATTTCGATGACGCCCAGCGTCAGGGTACCAAGGACGCGGCCAGACTGGCCGGTCTGCACGTGCTGCGGTTGCTCAACGAACCCACGGCGGCCGCCATCGCCTATGGCCTCGACTCCGGTCAGGAAGGGGTGATCGCCGTCTATGACCTGGGGGGCGGAACCTTCGATATCTCCATCCTGCGCCTGCATCGCGGGGTGTTTGAGGTGATGGCCACCGGTGGCGACTCGGCACTCGGTGGTGACGATTTTGACCATCTGCTGGCGGACTGGCTCAAAGAGCAAGCCGGGTTGTCCGGTCAGCTCGATGCCCGTACCCAGCGCGAGTTGCTGGATGCGGCGGCCAGCATCAAGCACGGCCTCACCGATGCCGATGCCGTTACCTGCACCTTTGCCGGCTGGCAGGGTACCGTCACCCGCAGCCAGTTTGACGAGCTGATCCAGCCCCTGGTCAAGCGCACCCTGCAGGCCTGTCGGCGCGCCCTGCGCGATGCGGGTCTCGAGCAGGAAGAGGTGCTGGAAGTGGTGATGGTCGGTGGCTCGACCCGGGTGCCGCTGGTGCGCGAGCGGGTGGGCGAGTTCTTCGGCCGCACGCCCTTGACCAGCATCGACCCTGACAAGGTGGTGGCCATTGGTGCCGCCATCCAGGCCGACATCCTGGTGGGCAACAAGCCCGACGCCGAGATGCTGCTGCTGGACGTCATCCCGCTTTCCTTAGGGTTAGAGACCATGGGCGGCCTCGCCGAGAAGGTGATCCCGCGCAATACCACCATTCCGGTGGCCCGCGCCCAGGAGTTCACCACCTTCAAGGATGGCCAGACCGCAATGGCCATCCACGTGGTGCAGGGGGAGCGCGAGCTGGTGGCGGATTGCCGCTCCCTGGCCCGCTTCACCCTGACCGGCATTCCGCCCATGGCGGCGGGGGCGGCCCACATTCGCGTTACCTTCCAGGTGGATGCGGACGGTCTGCTGTCGGTCAGCGCCATGGAGAAATCCTCCGGCGTGCAGGCCGAGATCCAGGTCAAGCCCTCCTATGGACTGGGTGAGGATGACATCCTCAACATGCTGAGCGCCTCCATCGCCAATGCCCAGCAGGACATGGACGCCCGCATGTTAGCGGAGCAACAGGTCGAGGCCGACCGGGTGGTCGAGAGTCTCAACGCCGCCCTGGCCGCCGATGGCGAGGCCTTATTGAGCCCCGCCGAGCGGGTCGAGCTGGATGCCGCCATCGCCCATCTGCTGACCATGCGCAGCACGGGCACCACCAACCAGATCAAAGAGGCCATCGAGGCGGCGGACGCTGCCAGTGGCGAATTTGCAGCCCGCCGGATGGATGCCTCCATCCGCAAGGTGCTGACCGGACAAAACGTCAACAAGGTGTGATATGCCAAAACTGATTATTCTGCCCCATCCCGAGCTCTGTCCGGACGGCGCGGCCCTCGAAGGTGCGACCGGTGAAACCATTCTGGATATCGCGCTGCGCAATGGCATCGAGATCGAGCACGCCTGCGAGAAGTCCTGTGCCTGCACCACCTGCCACTGCGTGGTGCGGGAAGGGTTCGACTCCCTCGAGCCGAGCGACGAGCTGGAAGACGACATGCTGGACAAGGCGTGGGGGCTGGAGCCGGAATCCCGTCTCAGCTGCCAGGCCAGACTGGCGGACGAGGATCTGGTGGTGGAACTGCCCAAGTACACCCTGAATCTGGCGTCCGAGCGCCACTGATGACCCCTTAATTACACATGAGTGAATTGCGCGTGCAGCATCTCATGGTGCAGTAATGATATGGTGAAGGCCGTGACCCTTGAGGGAGCGGCCTTTTTTGTGCCCGTGATTTCCCTATTCGTTGATGAAAGTGCCAATAAAAAGGAAGCAAGAGAACATGGCTGACATGATGAACGTAAGGTTGTCGTCCCAGGCTGCCGCCGCCCAGTGGGGTGAGGGTGCCCTGCTCAGTTTCAACGGGGACGAGGCTCATCTCCATCTGGCTGCTGGCCAGGAGAAGGAGGCGCTGCGCGCCATCCAGCGCGGGGCCAGACGCCTCGAGTCGAGCGGCATCAAGCGCATCAAGCTGGTGGGCGAGGGGTGGGATCGGGAGCGTCGTTACGCCTTTGCCCAGGGCTTCTATGCCGCCAAGGGGGTTCGCGAGCTCGACTTCGGCGAGCAGAGCGACCAGGAGGCTGCCGAGCTGGCGGCTTTGCTCAAAGCGACCCACTGGGTGCGCGAGGTGACCAACGGCTGCCCGGAAGCCATCTACCCCATGAGCCTGGCGGAGTCCGCTCTGCTGCTCATTCGCAGCCTCGGCGGTGACAAGGTGACCGCCCGCATCACCGCTGGCGAAGCCTTGCGTGAATCGGGTCATATCGGGATCTGGTCGGTGGGCCGTGGCAGCGAGCGCGAGCCGGTGCTGCTGGAGCTCGACTACAACCCGACCGGGGATGCCAACGCCCCCGTGGTCGCGGCGCTGGTGGGCAAGGGGATCACCTTCGATTCCGGCGGCTACTCCATGAAGTCCTCCGACAACATGCTGCCGATGAAGTCCGACATGGGCGGCGCCGCCATGGTGACCGGCGCCCTGGCGCTGGCCATCAGCCGTGGCCTGAACAAGCGGGTCAAGCTCATCCTCTGCTGCGCCGAGAACCTGGTCTCCGGCCACGCCTTCAAGCTCGGCGACATCCTCACCTATCGCAACGGCATCTCGGTCGAGATCCAGAACACCGATGCGGAAGGTCGCCTGGTGCTGGCAGACGGCCTGCTGGCCGCCAGCGAAAGCGGGGCTGCCTACATCCTCGACGCTGCCACCCTGACCGGCGCCGCCAAGACAGCGCTGGGCCGCGACTACAATGCCGTGTTTGCCCTCGATGAGGCGGAGCAGGTGCGCGCGCTGGCTGCCGCCAACGCCGAAAACGAGAAGGCCTGGCCGCTGCCGCTCGAACCCTGGCACGCAGGCCAGCTCACCTCGGCCTTTGCCGAGCTGGGCAACGTGGCGTCCGCCGAAGGCACTGCCGGTGCCACCACCGCAGCGGCTTTCCTGTCGCGCTTTGTCCGTGACGAAGGCAAGGGCTGGGTGCACCTGGACCTGGCCGCTTCCTATCAGAAGTCGGGCAATGATCTCTGGGCGACCGGTGCCAAGGGCCATGGTCTTCGCACGATTGCCCGCTGGTTGCAGGAGGTGTGCGCATGAACGTCTGGTTGAGCCGAGAGTTTGCACCGGCCGAGTGGGGGGAGGGGGCACTGCTCTCCCACCGTGCCGACGGCATGGTGATCCATCTGGTGAGCGCCACTCCCTTGCTGGATATCCAGCAGGCGGCGCGGCGCCTGTGCAGCCAGGGGATCCAGCAGGTGGTCCTGGCTGGCCACTGGGAGCGGGAGCAGCAGTGGGCCTTTGCCCAGGGGCTGCAGACGCCCAAGGCGGAAGTGGGGTTGCAGTGGGCCACTTCGTCCGAGGAGGACAGGGAGGAGCTGGAGGCGCGCTGGCTGTGCGGGCGCTGGGTGCGGGAGATGACCAACGCCACCCCGGAGCAGCTGGGGCCGCTGGAGCTGGCGGTCGAAGCCGCCGCCTTCCTCACCGAGCTGGCACCGGACCGGATCAGCCATCGCATCCTCAAGGGAGAGGCGCTGCAACAGGCGGGCTGGGTCGGTCTCTATCAAGTGGGTCGTGGCAGTGACCGCGAGCCCGTGATGCTGGAGCTGGATTTCAATCCGGGCAAGGATCCCAAGGCGCCGGTAGCGGCCGCCCTGGTGGGCAAGGGGATCACCTTCGATTCCGGCGGCTACTCCATGAAGACCTCCCAGGGCATGCTGACCATGAAACACGACATGGGCGGTGCCGCCATCGTCACCGGCGCGCTGGCGCTGGCCATTCTGCGTGGCCTCGACAAGCGGGTGAAGCTCATCCTCTGCTGCGCCGAGAACCTGGTATCCGGCCATGCCTACAAGCTGGGTGACATCCTCACCTACAAGAACGGCACCACGGTGGAGGTGGTCAATACCGACGCCGAAGGGCGTCTGATCCTGGCCGACGGCTTGCAACTGGCCGGCGAGTCTGGTGCGCCGCTCATCATCGACGCCGCCACCCTCACCGGGGCGGCCGTGATGGCGCTGGGAGGGCGTTACAACGCCCTGTTTGGACTGGACAAGGGGCTGGTGAGCCGCGCCATGGCCTATTCGGATGCGGAGCAGGAGCCAGCATGGCCGCTCCCGCTGGAGCCCTGGCATCGCCAGCAGTGCCCGTCCCACTATGCCGACACCGCCAACAGCCGCCCCGTGCCGGGCGGCGGACCGGGGGGCGCCTCCAACGCGGCGGGCTTCCTCTCCCGCTTTGTCCCTGATGAGGGAAGAGGGTGGCTGCATGTCGATCTCGCCGCCTGCTTCAGCGAAAACGGCGATAGTCTGTGGGCGCCCGGGGCCAATACCCTGGGGATGCGCACCATCGCCCATACCCTGATGGCGGAGACGCGCTGA

Protein sequences of DBSCAN-SWA_3

>NZ_LS483441|1924919:1932575|1926188_1926572_+|WP_010675059.1|DBSCAN-SWA
MAYSEKVIDHYENPRNVGGFDKNDPSVATGMVGAPACGDVMKLQLKISDDGIIEDAKFKTYGCGSAIASSSLVTEWVKGKTLDEAAGIKNTDIAEELALPPVKIHCSILAEDAIKAAIADYKQKKGL
>NZ_LS483441|1924919:1932575|1926587_1926911_+|WP_010675058.1|DBSCAN-SWA
MAITMTDAAAARVSSFMINRGKGIGLRLGVKTTGCSGLAYVLEFVDELAAEDQVFEQKGVKIIVDAKSLIHLDGTELDFVKEGLNEGFQFNNPNAKGECGCGESFSV
>NZ_LS483441|1924919:1932575|1931291_1932575_+|WP_039038726.1|DBSCAN-SWA
MNVWLSREFAPAEWGEGALLSHRADGMVIHLVSATPLLDIQQAARRLCSQGIQQVVLAGHWEREQQWAFAQGLQTPKAEVGLQWATSSEEDREELEARWLCGRWVREMTNATPEQLGPLELAVEAAAFLTELAPDRISHRILKGEALQQAGWVGLYQVGRGSDREPVMLELDFNPGKDPKAPVAAALVGKGITFDSGGYSMKTSQGMLTMKHDMGGAAIVTGALALAILRGLDKRVKLILCCAENLVSGHAYKLGDILTYKNGTTVEVVNTDAEGRLILADGLQLAGESGAPLIIDAATLTGAAVMALGGRYNALFGLDKGLVSRAMAYSDAEQEPAWPLPLEPWHRQQCPSHYADTANSRPVPGGGPGGASNAAGFLSRFVPDEGRGWLHVDLAACFSENGDSLWAPGANTLGMRTIAHTLMAETR
>NZ_LS483441|1924919:1932575|1929497_1929836_+|WP_005299781.1|DBSCAN-SWA
MPKLIILPHPELCPDGAALEGATGETILDIALRNGIEIEHACEKSCACTTCHCVVREGFDSLEPSDELEDDMLDKAWGLEPESRLSCQARLADEDLVVELPKYTLNLASERH
>NZ_LS483441|1924919:1932575|1924919_1926134_+|WP_042016656.1|DBSCAN-SWA
MKLPIYLDYSATCPVDPRVAEKMMQCLTMDGLFGNPASRSHRFGWQAEEAVDLARNQVAELIGADPREIVFTSGATESNNLAIKGIAHFYAGKGKHIVTSKTEHKAVLDTCRQLEREGYEVTYLEPMPNGLFTLEQIEGALRDDTILVSIMHANNEIGVVQDIAAIGELCRSRKILLHVDAVQSVGKIPVDVEALKVDLLSMSAHKVYGPKGIGALYVRRKPRVRLEAQMHGGGHERGMRSGTLATHQIVGMGEAFRIAKEEMASESQHIMALRQRLWNGIKNIEEVYINGDLDQRVPGNLNVSFAYVEGESLIMALKDLAVSSGSACTSASLEPSYVLRALGLNDELAHSSIRFSIGRFTTEEEIDYAIKLICDSIGRLREMSPLWEMFKDGVDLNTVEWAHH
>NZ_LS483441|1924919:1932575|1929993_1931295_+|WP_042016654.1|DBSCAN-SWA
MADMMNVRLSSQAAAAQWGEGALLSFNGDEAHLHLAAGQEKEALRAIQRGARRLESSGIKRIKLVGEGWDRERRYAFAQGFYAAKGVRELDFGEQSDQEAAELAALLKATHWVREVTNGCPEAIYPMSLAESALLLIRSLGGDKVTARITAGEALRESGHIGIWSVGRGSEREPVLLELDYNPTGDANAPVVAALVGKGITFDSGGYSMKSSDNMLPMKSDMGGAAMVTGALALAISRGLNKRVKLILCCAENLVSGHAFKLGDILTYRNGISVEIQNTDAEGRLVLADGLLAASESGAAYILDAATLTGAAKTALGRDYNAVFALDEAEQVRALAAANAENEKAWPLPLEPWHAGQLTSAFAELGNVASAEGTAGATTAAAFLSRFVRDEGKGWVHLDLAASYQKSGNDLWATGAKGHGLRTIARWLQEVCA
>NZ_LS483441|1924919:1932575|1927101_1927620_+|WP_041215018.1|DBSCAN-SWA
MNHFELFGLAEGFELDTRQLADTYRQLQTQFHPDRFATAPEREQLAAVQRAAQINDAFTTLKAPLRRAEYLLSLRGTDIRGEQQTLQDPAFLMQQLEWRERLADLKGDADPEGAIKDFRQEIRHDHLVLMQRLTDSLTRGEDLQAADCVRKLKFVDKLLEELERFEDSLFES
>NZ_LS483441|1924919:1932575|1927648_1929496_+|WP_042016655.1|DBSCAN-SWA
MALLQIAEPGQSAAPHQHKRAVGIDLGTTNSLVAAVRSGQADTLCDEQGRDLLPSVVHYQADTIRVGFDAKREAALDPHNTIVSVKRMMGKGLADIDTRQQPYEFVATETGMPQLRTRQGLVNPVQVSAEILKKLAERGAASLGGDLDGVVITVPAYFDDAQRQGTKDAARLAGLHVLRLLNEPTAAAIAYGLDSGQEGVIAVYDLGGGTFDISILRLHRGVFEVMATGGDSALGGDDFDHLLADWLKEQAGLSGQLDARTQRELLDAAASIKHGLTDADAVTCTFAGWQGTVTRSQFDELIQPLVKRTLQACRRALRDAGLEQEEVLEVVMVGGSTRVPLVRERVGEFFGRTPLTSIDPDKVVAIGAAIQADILVGNKPDAEMLLLDVIPLSLGLETMGGLAEKVIPRNTTIPVARAQEFTTFKDGQTAMAIHVVQGERELVADCRSLARFTLTGIPPMAAGAAHIRVTFQVDADGLLSVSAMEKSSGVQAEIQVKPSYGLGEDDILNMLSASIANAQQDMDARMLAEQQVEADRVVESLNAALAADGEALLSPAERVELDAAIAHLLTMRSTGTTNQIKEAIEAADAASGEFAARRMDASIRKVLTGQNVNKV

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_042016656.1|1924919_1926134_+	IscS subfamily cysteine desulfurase	A0A0H3TPH2	Faustovirus	2.3e-33	30.3
WP_010675059.1|1926188_1926572_+	Fe-S cluster assembly scaffold IscU	A0A218MKD1	uncultured_virus	2.8e-54	79.0
WP_010675058.1|1926587_1926911_+	iron-sulfur cluster assembly protein IscA	A0A2H4N7N5	Lake_Baikal_phage	1.2e-21	43.9
WP_041215018.1|1927101_1927620_+	co-chaperone HscB	NA	NA	NA	NA
WP_042016655.1|1927648_1929496_+	Fe-S protein assembly chaperone HscA	A0A0N9QXN8	Chrysochromulina_ericina_virus	1.7e-104	41.6
WP_005299781.1|1929497_1929836_+	ISC system 2Fe-2S type ferredoxin	NA	NA	NA	NA
WP_042016654.1|1929993_1931295_+	aminopeptidase PepB	Q6GYZ8	Mycoplasma_phage	1.3e-34	35.6
WP_039038726.1|1931291_1932575_+	aminopeptidase PepB	Q6GYZ8	Mycoplasma_phage	3.3e-30	37.4