CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_LS483488	Helicobacter pylori NCTC 11637 = CCUG 17874 = ATCC 43504 strain NCTC 11637 chromosome 1	1 crisprs	DEDDh,cas14j,cas2,cas3	0	0	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_LS483488_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LS483488_1

859125-859219

Orphan

Consensus_repeat	Method
CTTTTTGTCGTTTTTAGCCTCGGTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_LS483488_1

>merge|NZ_LS483488|1|859125-859219|CRISPRCasFinder
CTTTTTGTCGTTTTTAGCCTCGGTTTTTAATCCATGGTTTTTATGGAGTTTGTAAAACTTTTTACCGCTCTTTTTGTCGTTTTTAGCCTCGGTTT

>NZ_LS483488|1|1|859125-859219|CRISPRCasFinder
CTTTTTGTCGTTTTTAGCCTCGGTTT	TTAATCCATGGTTTTTATGGAGTTTGTAAAACTTTTTACCGCT
CTTTTTGTCGTTTTTAGCCTCGGTTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LS483488.1\|WP_108168867.1\|856788_857325_+\|hydrogenase-biosynthesis-protein-HydD	unknown	unknown	gnl\|CDD\|99873
NZ_LS483488.1\|WP_108168876.1\|866154_866448_+\|YggT-family-protein	unknown	unknown	gnl\|CDD\|223833
NZ_LS483488.1\|WP_108168866.1\|856117_856792_+\|Ni/Fe-hydrogenase,-b-type-cytochrome-subunit	unknown	unknown	gnl\|CDD\|224880
NZ_LS483488.1\|WP_111735922.1\|850363_850558_+\|DUF262-domain-containing-protein	unknown	unknown	gnl\|CDD\|224396
NZ_LS483488.1\|WP_108168865.1\|854368_856105_+\|nickel-dependent-hydrogenase-large-subunit	unknown	unknown	gnl\|CDD\|366057
NZ_LS483488.1\|WP_108168870.1\|859425_859857_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LS483488.1\|WP_108168874.1\|863161_864019_+\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224995
NZ_LS483488.1\|WP_108168863.1\|852460_853045_-\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|225158
NZ_LS483488.1\|WP_108168862.1\|849099_850158_+\|sel1-repeat-family-protein	unknown	unknown	gnl\|CDD\|223861
NZ_LS483488.1\|WP_165695278.1\|863009_863147_+\|hypothetical-protein	unknown	unknown	unknown
NZ_LS483488.1\|WP_108168871.1\|860048_860972_+\|outer-inflammatory-protein-OipA	unknown	unknown	gnl\|CDD\|280099
NZ_LS483488.1\|WP_108168868.1\|857326_858865_+\|protein-hydE	unknown	unknown	unknown
NZ_LS483488.1\|WP_108168875.1\|864838_866158_+\|glutamate--tRNA-ligase	unknown	unknown	gnl\|CDD\|237094
NZ_LS483488.1\|WP_000892493.1\|846800_847880_+\|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	unknown	unknown	gnl\|CDD\|377382
NZ_LS483488.1\|WP_108168877.1\|866461_868144_+\|lytic-transglycosylase-domain-containing-protein	unknown	unknown	gnl\|CDD\|381604
NZ_LS483488.1\|WP_000591495.1\|868140_868962_+\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	unknown	unknown	gnl\|CDD\|224131
NZ_LS483488.1\|WP_108168861.1\|847882_849088_+\|2,3,4,5-tetrahydropyridine-2,6-carboxylate-N-succinyltransferase	unknown	unknown	gnl\|CDD\|225082
NZ_LS483488.1\|WP_108168873.1\|861787_862996_+\|CCA-tRNA-nucleotidyltransferase	unknown	unknown	gnl\|CDD\|223690
NZ_LS483488.1\|WP_108168864.1\|853204_854359_+\|hydrogenase-1-small-subunit	unknown	unknown	gnl\|CDD\|273053
NZ_LS483488.1\|WP_108168872.1\|861038_861725_-\|7-cyano-7-deazaguanine-synthase-QueC	unknown	unknown	gnl\|CDD\|129461

Protein	Function_ID	Function_description	E-value
NZ_LS483488.1\|WP_108168867.1\|856788_857325_+\|hydrogenase-biosynthesis-protein-HydD	gnl\|CDD\|99873	cd06062, H2MP_MemB-H2up, Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD from E. coli is well studied in this group. Maturation of [NiFe] hydrogenases include proteolytic processing of large subunit, assembly with other subunits, and formation of the nickel metallocenter. Hydrogenase maturation endopeptidase (HybD) cleaves a short C-terminal peptide after a His or an Arg residue in the large subunit (pre-HybC) of hydrogenase 2 (hyb operon) in E. coli. This cleavage is nickel dependent. A variety of endopeptidases belong to this group that are similar in function and sequence homology. They include such proteins as HynC, HoxM, and HupD.	5.83999e-58
NZ_LS483488.1\|WP_108168876.1\|866154_866448_+\|YggT-family-protein	gnl\|CDD\|223833	COG0762, COG0762, Predicted integral membrane protein [Function unknown].	3.55741e-07
NZ_LS483488.1\|WP_108168866.1\|856117_856792_+\|Ni/Fe-hydrogenase,-b-type-cytochrome-subunit	gnl\|CDD\|224880	COG1969, HyaC, Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion].	1.98024e-95
NZ_LS483488.1\|WP_111735922.1\|850363_850558_+\|DUF262-domain-containing-protein	gnl\|CDD\|224396	COG1479, COG1479, Uncharacterized conserved protein [Function unknown].	1.77045e-06
NZ_LS483488.1\|WP_108168865.1\|854368_856105_+\|nickel-dependent-hydrogenase-large-subunit	gnl\|CDD\|366057	pfam00374, NiFeSe_Hases, Nickel-dependent hydrogenase.	0
NZ_LS483488.1\|WP_108168874.1\|863161_864019_+\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|224995	COG2084, MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism].	3.24315e-90
NZ_LS483488.1\|WP_108168863.1\|852460_853045_-\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|225158	COG2249, MdaB, Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only].	6.62148e-52
NZ_LS483488.1\|WP_108168862.1\|849099_850158_+\|sel1-repeat-family-protein	gnl\|CDD\|223861	COG0790, COG0790, FOG: TPR repeat, SEL1 subfamily [General function prediction only].	1.12896e-45
NZ_LS483488.1\|WP_108168871.1\|860048_860972_+\|outer-inflammatory-protein-OipA	gnl\|CDD\|280099	pfam01856, HP_OMP, Helicobacter outer membrane protein. This family seems confined to Helicobacter. It is predicted to be an outer membrane protein based on its pattern of alternating hydrophobic amino acids similar to porins.	2.18866e-34
NZ_LS483488.1\|WP_108168864.1\|853204_854359_+\|hydrogenase-1-small-subunit	gnl\|CDD\|273053	TIGR00391, small_subunit, hydrogenase (NiFe) small subunit (hydA). Called (hupA/hydA/hupS/hoxK/vhtG) Involved in hydrogenase reactions performing different specific functions in different species eg (EC 1.12.2.1) in Desulfovibrio gigas,(EC 1.12.99.3) in Wolinella succinogenes and (EC 1.18.99.1) in E.coli and a number of other species and (EC 1.12.99.-) in the archea. [Energy metabolism, Electron transport].	0
NZ_LS483488.1\|WP_108168875.1\|864838_866158_+\|glutamate--tRNA-ligase	gnl\|CDD\|237094	PRK12410, PRK12410, glutamylglutaminyl-tRNA synthetase; Provisional.	0
NZ_LS483488.1\|WP_000892493.1\|846800_847880_+\|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	gnl\|CDD\|377382	pfam04551, GcpE, GcpE protein. In a variety of organisms, including plants and several eubacteria, isoprenoids are synthesized by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Although different enzymes of this pathway have been described, the terminal biosynthetic steps of the MEP pathway have not been fully elucidated. GcpE gene of Escherichia coli is involved in this pathway.	0
NZ_LS483488.1\|WP_108168877.1\|866461_868144_+\|lytic-transglycosylase-domain-containing-protein	gnl\|CDD\|381604	cd13401, Slt70-like, 70kDa soluble lytic transglycosylase (Slt70) and similar proteins. Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.	3.5019e-51
NZ_LS483488.1\|WP_000591495.1\|868140_868962_+\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	gnl\|CDD\|224131	COG1210, GalU, UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane].	5.49102e-162
NZ_LS483488.1\|WP_108168861.1\|847882_849088_+\|2,3,4,5-tetrahydropyridine-2,6-carboxylate-N-succinyltransferase	gnl\|CDD\|225082	COG2171, DapD, Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism].	1.37932e-90
NZ_LS483488.1\|WP_108168873.1\|861787_862996_+\|CCA-tRNA-nucleotidyltransferase	gnl\|CDD\|223690	COG0617, PcnB, tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis].	2.47243e-93
NZ_LS483488.1\|WP_108168872.1\|861038_861725_-\|7-cyano-7-deazaguanine-synthase-QueC	gnl\|CDD\|129461	TIGR00364, 7-cyano-7-deazaguanine_synthase, queuosine biosynthesis protein QueC. Members of this protein family are QueC, involved in synthesizing pre-Q0 from GTP en route to tRNA modification with queuosine. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In Rhizobium meliloti, the gene was designated exsB, possibly because of polar effects on exsA expression in a shared polycistronic mRNA. In Arthrobacter viscosus, the homologous gene was designated ALU1 and was associated with an aluminum tolerance phenotype. [Unknown function, General].	3.82552e-110

>NZ_LS483488.1|WP_108168868.1|857326_858865_+|protein-hydE
MAFVFLFKCVNEETSLNFTPLLERMACNLQARFYSVYKDNTTSFYLQASAEITLEFAQKLSEILPFSLDFSFLSLKEITDPLDENLFQTTSLSKPLFMNAKEHQDFLDKNASLYANALGFVKNTAFKGDIIHSPKELIDCLIQLKGMLKTQDFIPVHTSRGALSLSLKKLSPSVIFSDLSSVLSCTKLPLEDAKYLASLEKPSIKAPLKSVFKDTFKNDEIIVQLPYDPILNLLCHILQDEGIEFVFIHANDPQEALLHYEALFKTPKRLITPTKKFVLENNLSTLPFKDELEFLSTTPNSIVLYFSFKRPTRLLLHANGSLKTLLSVSFDFNQIFNLLKQDEKASRMLQNYATKFPDFYARLLELSKYNLGGTNLLDFFQILGFILGYSEDFCTQSVISLAKECLRPKGPRIDYKILKDDSLKMALNFSKIMHSAMSFRLAGVENEILSLGILDSLAEFLGNFIWDNVQNFSVQEVTIAGDFFGEKVFLDLFVQYFPKTLTLKTHAFLDYE
>NZ_LS483488.1|WP_108168867.1|856788_857325_+|hydrogenase-biosynthesis-protein-HydD
MSQKILILGIGNILFGDEGIGVHLAHYLKRNFSFFPSVDIIDGGTMAQQLIPLITSYEKVLILDCVSAKGVEIGSVYAFDFKDAPKEITWAGSVHEVEMLHTLRLTEFLGDLPKTFIVGLVPFVIGSETTFKLSSEMLNALETALKAIETQLNAWGVKMQRTDHIALDCIAELSYKGF
>NZ_LS483488.1|WP_108168866.1|856117_856792_+|Ni/Fe-hydrogenase,-b-type-cytochrome-subunit
MDKMNKVVLHKEYSGFVRFFHWVRALSIFALIATGFYIAYPFLQPNSSFYKGVYLLQAYVRSFHVMFGFLLISALIFRTYLFFTKESLMERRSFSQLLSPKAWIDQMKAYFLISGKPHTKGAYNPIQLVAYSTLIVLIVLMSLSGIVLYYNVYHAGLGAFLGSAFKWFETLCGGLANVRFIHHLATWGFILFVPVHVYMVFFHSIRYESSGADSMINGYGYTKE
>NZ_LS483488.1|WP_108168865.1|854368_856105_+|nickel-dependent-hydrogenase-large-subunit
MSKKIVVDPITRIEGHLRIEVIVDDDNVITDAFSSSTLFRGLETIIKGRDPRDAGFIAQRICGVCTYSHYKAGITAVENALGITPPLNAQLVRSLMNMALLFHDHVVHFYTLHGLDWCDILSALKADPIQAAKLSFKYSPYPINTGAGELKAVQKRLNDFAKSGSLGPFSNGYYGHKTYRLNPEQNLIVLSHYLKLLEIQREAAKMTAIFGAKQPHPQSLTVGGVTSVMDILDPTRLAEWKSKFEVVANFINHAYYPDLVMAGEMFANEQSVIKGCGLRNFIAYEEVLLGKDKYLLSSGVVLDGDISKLHPIDESLIKEEVTHSWYQYKDTKEVQLHPYDGQTNPHYTGLKDGESVGIENKTIPAKVLDTQNKYSWIKSPRYDSKPMEVGPLSSVVVGLAAKNPYVTEVATKFLKDTKLPLEALFSTLGRTAARCIEAKTIADNGLLAFDALVENLKSDQSTCTPYHIDKNQEYKGRYIGQVPRGMLSHWVRIKNGVVENYQAVVPSTWNAGPRDSQNQRGAYEMSLIGTKIADLTQPLEIIRTIHSFDPCIACSVHVMDFKGQSLNEFKVEPNFAKF
>NZ_LS483488.1|WP_108168864.1|853204_854359_+|hydrogenase-1-small-subunit
MFYDEKKTYQKIEERLDIVSSFNAHNEHKNLQDEFKDAGISRRDLLKWAGMMSTALALPASFAPLTLKAVEVANRLPVIWLHMAECTGCSESLLRSADPTIDSIIFDYINLEYHETIMVASGFQAEKSLHDAIEKHKNNYILMVEGGIPQGTEYFLTQGPNAETGAEECRKAAQYAAAIFAIGTCSSFGGVQAAYPNPSNAQPLHKIIDKPVINVPGCPPSEKNIVGNVLYYLMFGALPKLDAYNRPSWAYGNRIHDLCERRGHFDAGEFVEHFGDENAKRGFCLYKMGCKGPYTFNNCSKLRFNSHTSWPIGAGHGCIGCSEPNFWDTMSPFEEPLANRSIKTAFDGLGADKVADKVGTTLLSATAIGIVAHALLSKAIKNKE
>NZ_LS483488.1|WP_108168863.1|852460_853045_-|NAD(P)H-dependent-oxidoreductase
MKKVLIINGAKAFGSSGGKLNETLTDHAKKTLESLGLEVDTTIVDKGYNHSQEVEKVFSADATIWQMPGWWMGEPWIVKKYIDEVFSAGHGKLYASDGRSSQNPTKNYGKGGLMQGKKYMLSLTWNAPIEAFNDPSEFFEGVGVDVVYLHLHKAFQFLGLSALPTFICNDVMKNPQVEQYLNSLTMHLHQAFGK
>NZ_LS483488.1|WP_111735922.1|850363_850558_+|DUF262-domain-containing-protein
MKATQSTVNDFFALTSTIFSIPVYQRNYTWEEENCEKLLQDIISISQNKKNAFHGFYHLYTASY
>NZ_LS483488.1|WP_108168862.1|849099_850158_+|sel1-repeat-family-protein
MLKKSLLLFVFLVLQLSGAEENNQAPKNTPPELNPANAKGAPNPNTQITPKNDNSNLLDKLGSPENAQTELSAGIDLAKKGDYQGAFKLFSQSCDNGNAAGCFAVGAMYANGVGIQTNRLKAARYYEMGCSGGDATACANLAQMYENKKNADTNDKENALQLYAVACQGGDMLACNNLGWMFANGSGVQKDYYKAISYYKFSCENGNDMGCYNLGLMSNVNNIYGIDKAQLSQVDLNYLACNAGDMMGCANLGWIYANGDLGAPLNNHYAAKYFQMACDGGILGSCNNLGVLYQKGLGVPQDDQRALDLFSYACDNGFESSCRNYGNFKEHLLRVNPNYGRLFMPYHSYEIP
>NZ_LS483488.1|WP_108168861.1|847882_849088_+|2,3,4,5-tetrahydropyridine-2,6-carboxylate-N-succinyltransferase
MINKFKNFVSNYQQSNHYKEPLGFGIARVDIAPISKKILCATYPVLNWKDENLGSYVVFCNSLSKEKILKESASERVIEIDESFVLKVLDFYTPFLNEAYSNKMAHKNIQVVLELLKALEENRLKNSDGESLYRLVILYEDKPCESVESAYMKLLALSLGKAPLRSLNLEGIFNQLSNAAWSGNKPYELEWLRMNEVALKMRGHFPSIDFIDKFPRYLMQLIPEFDNIRLLDSSKTRFGAYLGTGGYTQMPGASYVNFNAGAMGVCMNEGRISSSVVVGAGTDIGGGASVLGVLSGGNNNPISIGKNCLLGANSVTGISLGDGCIVDAGVAILAGSVIEIEENEFKKLLEVNSALEKHANNLYKGKELSGKNGVHFRSNSQNGKLIAFRSVKKIELNQNLH
>NZ_LS483488.1|WP_000892493.1|846800_847880_+|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase
MLENRVKTKQIFIGGVAIGGDAPISTQSMTFSKTADIESTKNQIDRLKLAGADLVRVAVSNEKDALALKELKKVSSLPLIADIHFHYKFALIAAQSVDAIRINPGNIGSKDKIKAVVDACKEKNIPIRIGVNAGSLEKQFDQKYGPTPKGMVESALYNAKLLEDLDFTDFKISLKASDVMRTIEAYRMLRPLVIYPFHLGVTEAGNLFSSSIKSAMALGGLLMEGIGDTMRVSITGELENEIKVARAILRHSGRLKEGINWISCPTCGRIEANLVDMASKVEKRLSHIKTPLDISVMGCVVNALGEAKHADMAIAFGNRSGLIIKEGKVIHKLAEKDLFETFVIEVENLAKEREKSLKD
>NZ_LS483488.1|WP_108168870.1|859425_859857_-|hypothetical-protein
MHQNNKTFLPSQSAHLSKIILFLNTGFLAYLLSACGANVPIEEVLVKDPKETKAQEVAREEKAIQQENATIDARTTPLINRFTNYNAYGSLNGFYNSVDNLNSPMQNGMYGGYYMPYYYMPYGFMPYGPYGYGAPGYFPYVFY
>NZ_LS483488.1|WP_108168871.1|860048_860972_+|outer-inflammatory-protein-OipA
MKKALLLSLFLSFWLHAERNGFYLGLNFAEGSYIQGQGSIGEKASAENALNEAINNAKNSLFPTQNTKAIRDAQNALNAVKDSTKIANRFAGNGGSGGLFNELSFGYKYFLGKKRIIGFRHSLFFGYQLGGVGSVPGSGLIVFLPYGFNTDLLINWTNDKRASQKYVERRVKGLSIFYKDMTGRTLDANTLKKASRHVFRKSSGLVIGMELGGSTWFASNNLTPFNQVKSHTIFQLQGKFGVRWNNDEYDIDRYGDENYLGGSSVELGVKVPAFKVNYYSDNYGDKLDYKRVVSVYLNYTYNFKNKH
>NZ_LS483488.1|WP_108168872.1|861038_861725_-|7-cyano-7-deazaguanine-synthase-QueC
MGQEICVIGFSGGQDSTTLAVWAKKRFKKVCLVGFDYAQKHSVELECAQKIASLLQLPYEIISLDFLENITRSALFKNSNDLIGHSHAQNKDLPNSFVPNRNAIFITLLHSYAQKLGASNIALGVSQADFSGYPDCKEDFIKSIEHALNLGSNTAIKILTPLMFLNKAQEFQMAKDLGVLDLVIKETHTCYQGERKILHAYGYGCDECPACQLRKKGYEEFQTKVLFQ
>NZ_LS483488.1|WP_108168873.1|861787_862996_+|CCA-tRNA-nucleotidyltransferase
MFELEKGLKELFDIYEKSPHELYLVGGCVRDCLMGITPKDYDLTSNALVNESKELLLKHHFRVLETGIKHGTITALKNHQSYEITTFRMEKGHIKHRKPKELVFSARLTDDLKRRDFSMNAIAYSPTKGIVDPFKGQNAIRNQVIECVGEARLRFFEDALRILRALRFSATLGFKIAPSTKEAVFACKDLLKHLSKERLQSELNKLLMGKNAYEVAKEYQEILELVIQEKIENLGFLKNVPFNLELRLLGFFKHQKSLENLRYPKKTCVLFAQAKECHKAFLNIHNKTELKFLLKNYDLEPFNLALDFYALKNPKHALKIKSLLKEIFNANEPFKKEHLALKGGALQNLGYQCQQIGEILNECLNLVIAHPKNNALEWLIEWVKGHYLPNNAINHSPIGRKN
>NZ_LS483488.1|WP_165695278.1|863009_863147_+|hypothetical-protein
MITMDAIQWPKKWILGETDSFVSNEVIVKGLDFKKVVQHLMAYLC
>NZ_LS483488.1|WP_108168874.1|863161_864019_+|NAD(P)-dependent-oxidoreductase
MKIGWIGLGAMGTPMATRLCDAGLKVSVYNRTESKAAPLKEKGVAVYTNPIDLAAKVDLIFIMLSDKTAIDAVLVPEFWEQMSEKIVVNMSTIAPLESLALEKTAQKHQVTYLEAPVSGSVGAAKAGALLILAAGNKEVITQLKPVLVHLGSQTFYLGKIGQGTGAKLSINSLLAQMGVAYSEALLLAKHLGVDAELFLQIISQSGMNSPLFQAKKGMWLQDSYPAAFSLKLMLKDIRLANNEAGEAIKLPFLFQAEELYSQAEKSGLGALDMAAVYHYLEKGDH
>NZ_LS483488.1|WP_108168875.1|864838_866158_+|glutamate--tRNA-ligase
MLRFAPSPTGDMHIGNLRAAIFNYIVAKQQHKPFLIRIEDTDKERNIEGKDQEILEILKLMGISWDKLVYQSHNIDYHREMAEKLLKENKAFYCYASAEFLEREKEKAKNEKRPFRYSDEWATLEKDKHHAPVVRLKAPNHAVSFNDAIKKEVKFEPDELDSFVLLRQDKSPTYNFACACDDLLYEISLIIRGEDHVSNTPKQILIQQALGSNDPIVYAHLPIILDETSGKKMSKRDEASSVKWLLNQGFLPVAIANYLITIGNKVPKEVFNLDEAIEWFDLKNLSSSPAHFNLKYLKHLNHEHLKLLDDEKLLELTSIKDKNLLGLLRLFIEECGTLLELKEKISLFLEPKDIVKTYENEDFKERCLALFNALKSMDFQAYKDFESFKKEAMRLSQLKGKDFFKPLRILLTGNSHGVELPLIFPYIQSHYQEVLRLKA
>NZ_LS483488.1|WP_108168876.1|866154_866448_+|YggT-family-protein
MIFSTLVNAIAVILSSLITIYMWVVIIYSLLGFVQPNPNNPIMQILARLCEPVFYFLRSRFKLVFNGLDFAPLVVVIVLKFLDLTLIQWLFMLAKNL
>NZ_LS483488.1|WP_108168877.1|866461_868144_+|lytic-transglycosylase-domain-containing-protein
MRFFILFFIGMLGVGFSQTEFNLKDLEKKPAGIVRDYYLWRYISDKKTSLENAKKAYELTQNKNNALQKAMQEKGSDNSEKNPDVKLPEEIYCKQTALESMLEETDTFQASCIAIALKSKIRDFDKIPLQTLKPLQIKIKEAYPVLYEELEILQSKHVSASLFKANAQVFSALFNHLSYEKKLQIFEERIPIKELNRLLDENYPAFNRLIYQVILDPKLDHFKDALTKSNATQSNAQTFFILGINEILRKKPSKALKYFERSEAVVKDDDFSKDRAIFWQYLVSKKKKTLERLSQSPALNLYSLYASRKLQTTPSYRIISHIQNLSQEDPPFNTYDPFSWQIFKEKTLSLKGEDAFNAMLKSLYYEKSAPELTYLLSQRNKDKIYYYLSPYEGIIEWQNTDERAMAYAIARQESFLLPAVISRSFALGLMQIMPFNVGSFAKRLGMDNVDLNDMFNPNIALKFGNYYLNHLKKEFNHPLFVAYAYNAGPGFLRRWLESSKRFKEKNHFEPWLSMELMPYSETRLYGFRVMLNYLIYQEIFGNFIPIDGFLEQTLNSKDKP
>NZ_LS483488.1|WP_000591495.1|868140_868962_+|UTP--glucose-1-phosphate-uridylyltransferase-GalU
MIKKCLFPAAGYGTRFLPITKTIPKEMLPIVDKPLIQYAVEEAMEAGCEVMAIVTGRNKRSLEDYFDTSYEIEHQIQGTNKENALKSIRNIIEKCCFSYVRQKQMKGLGHAILTGEALIGNEPFAVILADDLCISHDYPSVLKQMTSLYQKYQCSIVAIEEVALEEVSKYGVIKGEWLEEGVYEIKDMVEKPSQEDAPSNLAVIGRYILTPDIFEILSETKPGKNNEIQITDALRTQAKRKRIIAYQFKGKRYDCGSVEGYIEASNAYYKKRL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

58368 : 69256

uncultured_Caudovirales_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_162296836.1\|58368_60414_+	DNA helicase UvrD	A7KV33	Bacillus_phage	4.1e-91	34.6
WP_108169443.1\|60410_61067_+	flagellar basal body P-ring formation protein FlgA	NA	NA	NA	NA
WP_000780122.1\|61076_61640_+	UbiX family flavin prenyltransferase	NA	NA	NA	NA
WP_108169444.1\|61639_62113_+	pantetheine-phosphate adenylyltransferase	A0A1B1IVQ3	uncultured_Mediterranean_phage	3.3e-28	45.5
WP_108169445.1\|62114_62690_+	dTMP kinase	Q2XUX0	environmental_halophage	2.2e-10	37.2
WP_108169446.1\|62677_63253_+	ComF family protein	NA	NA	NA	NA
WP_108169963.1\|63285_65325_+	N-6 DNA methylase	A0A2H4JBT5	uncultured_Caudovirales_phage	2.6e-210	57.7
WP_108169447.1\|65321_66515_+	restriction endonuclease subunit S	A0A2H4J4K4	uncultured_Caudovirales_phage	5.8e-05	30.0
WP_108169448.1\|66580_69256_+	DNA polymerase I	A0A218MKQ4	uncultured_virus	8.3e-60	37.3

DBSCAN-SWA_2

387102 : 423865

Helicobacter_phage(30.77%)

protease,transposase,integrase,tRNA

attL 384353:384368|attR 425724:425739

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
384353:384368	attL	NA	NA	NA	NA
WP_108169655.1\|387102_388347_+	DNA cytosine methyltransferase	M1PSQ0	Streptococcus_phage	5.5e-30	29.2
WP_108169656.1\|388333_389104_+	hypothetical protein	S0A2X1	Cellulophaga_phage	4.0e-55	48.1
WP_108169657.1\|389078_390425_+	McrB family protein	M1NSM1	Streptococcus_phage	2.4e-84	45.2
WP_108169658.1\|390417_391632_+	LlaJI family restriction endonuclease	Q6DMW8	Streptococcus_phage	3.2e-67	36.4
WP_108169659.1\|391712_392735_-	pseudaminic acid synthase	A0A1B1IVE2	uncultured_Mediterranean_phage	9.0e-31	34.1
WP_108169660.1\|392739_393381_-	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.4e-16	28.7
WP_108169661.1\|393380_394655_-	apolipoprotein N-acyltransferase	NA	NA	NA	NA
WP_001106292.1\|394882_395584_+	CvpA family protein	NA	NA	NA	NA
WP_108169663.1\|395593_397099_+\|tRNA	lysine--tRNA ligase	A0A1V0SAC0	Catovirus	4.6e-92	40.9
WP_108169664.1\|397098_398349_+	serine hydroxymethyltransferase	A0A240F3L3	Aeromonas_phage	1.8e-105	52.7
WP_000138102.1\|398359_398902_+	DUF1882 domain-containing protein	NA	NA	NA	NA
WP_108169665.1\|398923_399727_+	hypothetical protein	NA	NA	NA	NA
WP_108169666.1\|401706_402486_+	hypothetical protein	NA	NA	NA	NA
WP_108169667.1\|402505_402799_+	hypothetical protein	NA	NA	NA	NA
WP_108169668.1\|402805_404329_+	hypothetical protein	NA	NA	NA	NA
WP_108169669.1\|404325_404628_+	virB2 type IV secretion protein	NA	NA	NA	NA
WP_001173702.1\|404628_404895_+	hypothetical protein	NA	NA	NA	NA
WP_108169670.1\|404887_407311_+	VirB4 family type IV secretion/conjugal transfer ATPase	NA	NA	NA	NA
WP_108169671.1\|407313_409347_+	type IA DNA topoisomerase	A0A2K9L5F8	Tupanvirus	4.7e-47	31.8
WP_108169672.1\|409463_410633_+	hypothetical protein	NA	NA	NA	NA
WP_108169673.1\|410632_412165_+	TrbG/VirB9 family P-type conjugative transfer protein	NA	NA	NA	NA
WP_108169674.1\|412164_412533_+	DNA transformation compentancy	NA	NA	NA	NA
WP_108169144.1\|412529_413813_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A1S5REX3	Helicobacter_phage	1.9e-203	86.4
WP_162296838.1\|413864_414311_+\|transposase	IS200/IS605 family transposase	A0A1S5REW8	Helicobacter_phage	6.8e-76	98.6
WP_162296844.1\|414397_414682_-	hypothetical protein	NA	NA	NA	NA
WP_000159825.1\|414955_415246_-	hypothetical protein	NA	NA	NA	NA
WP_000795431.1\|415242_415698_-	hypothetical protein	NA	NA	NA	NA
WP_108169675.1\|415694_416636_-	Flp pilus assembly complex ATPase component TadA	NA	NA	NA	NA
WP_108169676.1\|416635_416935_-	hypothetical protein	NA	NA	NA	NA
WP_108169677.1\|416931_417195_-	hypothetical protein	NA	NA	NA	NA
WP_108169678.1\|417184_417481_-	hypothetical protein	NA	NA	NA	NA
WP_162296838.1\|418553_419000_-\|transposase	IS200/IS605 family transposase	A0A1S5REW8	Helicobacter_phage	6.8e-76	98.6
WP_108169679.1\|419051_420335_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A1S5REX3	Helicobacter_phage	2.7e-202	85.9
WP_053577294.1\|420412_420691_+	hypothetical protein	NA	NA	NA	NA
WP_108169680.1\|420692_421955_+	P-type conjugative transfer protein TrbL	NA	NA	NA	NA
WP_108169681.1\|422028_422712_+\|protease	CAAX protease	NA	NA	NA	NA
WP_108169682.1\|422791_423865_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
425724:425739	attR	NA	NA	NA	NA

DBSCAN-SWA_3

1296985 : 1303879

Helicobacter_phage(33.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_108169144.1\|1296985_1298269_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A1S5REX3	Helicobacter_phage	1.9e-203	86.4
WP_162296838.1\|1298320_1298767_+\|transposase	IS200/IS605 family transposase	A0A1S5REW8	Helicobacter_phage	6.8e-76	98.6
WP_108169146.1\|1298844_1299531_+	type II restriction endonuclease	A0A076FMQ7	Aureococcus_anophage	7.4e-29	38.9
WP_108169953.1\|1300173_1300767_+	Laminin subunit alpha-2 precursor	NA	NA	NA	NA
WP_108169147.1\|1300763_1301891_+	UDP-4-amino-4, 6-dideoxy-N-acetyl-beta-L-altrosamine transaminase	A0A2K9L0G1	Tupanvirus	2.5e-26	29.7
WP_000454012.1\|1302214_1303240_+	ribonucleotide-diphosphate reductase subunit beta	A2PYN0	Cyanophage	9.3e-52	34.3
WP_108169148.1\|1303249_1303879_+	protein-L-isoaspartate O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	2.3e-21	38.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage